tbuckley/cabot-search huggingface dataset:
Drug Treatment of Obesity—Reply
Authors: Lisa M. Schwartz, Steven Woloshin
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Henry Wirz (1822–1865)
Authors: Daniel Jackson
Journal: New England Journal of Medicine (1960)

THE trap opened. The prisoner fell, and the rope stretched taut. It was 10:30 a.m. on Friday, November 10, 1865. Henry Wirz, infantry major, C.S. Army, and a physician, was dead. He was the only man to be executed for war crimes in the War of the Rebellion.Henry Wirz was born in Zurich, Switzerland, in 1822, of German parentage. He worked in his father's woolen mills: then, after graduation at the University of Zurich, attended schools in Paris and Berlin, where he received his medical training. Marriage brought him 2 children. Upon the death of his wife in 1849, . . .
Anemia as a Primary Manifestation of Giant Cell Arteritis.
Authors: L. A. Healey
Journal: Annals of Internal Medicine (1969)

s1 May 1969Anemia as a Primary Manifestation of Giant Cell Arteritis.L. A. Healey, M.D., P. A. Simkin, M.D., K. R. Wilske, M.D.L. A. Healey, M.D.Search for more papers by this author, P. A. Simkin, M.D.Search for more papers by this author, K. R. Wilske, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1084_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis report describes seven older women whose primary problem was anemia. They sought medical attention because of fatigue and malaise; headache and muscle pains were either not present or so minor as to be overlooked. Their hematocrits ranged from 27 to 32%. The anemia was hypoproliferative, with low reticulocyte counts and adequate iron stores in the bone marrow.Thorough investigation failed to demonstrate malignancy, infection, or other cause for the anemia. In each, an erythrocyte sedimentation rate greater than 100 mm/hr prompted a biopsy of an asymptomatic temporal artery. In four of the seven patients giant-cell arteritis was found.All... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: L. A. Healey, M.D.; P. A. Simkin, M.D.; K. R. Wilske, M.D.Affiliations: Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnemia as a Presenting Manifestation of Giant Cell Arteritis 1 May 1969Volume 70, Issue 5Page: 1084-1084KeywordsAnemiaBiopsyBone marrowErythrocyte sedimentation rateFatigueGiant cellsHeadachesHematocritMyalgiaReticulocytes ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Use of trichlorethylene inhalations during physiotherapy.
Authors: M. W. Ellis, R. Bryce-Smith
Journal: BMJ (1965)

<h3>Background</h3> There are many possible predisposing factors for Achilles tendon disorders suggested in the literature but their pathogenetic relevance is not proven in most cases. The asymmetric mechanical load distribution within the Achilles tendon during locomotion is frequently addressed as a major risk factor for Achilles tendon disorders. The spatial orientation of the subtalar joint axis (STA) may influence the Achilles tendon loading possibly leading to overload injuries. <h3>Hypothesis</h3> There is a significant difference between the orientation of the STA in subjects with and without Achilles tendon pathologies. <h3>Materials and methods</h3> 614 subtalar joint axes determined in 307 long-distance runners with and without Achilles tendon disorders were included. Achilles tendon disorders were defined as any Achilles tendon–related pain during or following running, existing for more than 2 weeks in the past. Motion analysis of the foot was performed using an ultrasonic pulse-echo-based measurement system. The orientation of the STA was expressed by two angles. <h3>Results</h3> The mean inclination angle was 42±16° and the mean deviation angle was 11±23°. There was a significant difference (p=0.002) between the mean deviation angle measured in subjects with Achilles tendon pathologies (18±23°) and those without (10±23°). <h3>Conclusions</h3> The results demonstrate a wide interindividual variability of the spatial orientation of the STA. In addition, the mean deviation angle in people with Achilles tendon pathologies is significantly more oblique than in people without. This finding indicates that the spatial orientation of the STA is related to the incidence of overuse injuries of the Achilles tendon in the investigated sample.
Improving choice for patients from disadvantaged groups should reduce health inequalities
Authors: Susan Mayor
Journal: BMJ (2005)

Reforming the NHS to take more account of the needs of patients in disadvantaged groups could help to reduce health inequalities, says a report published this week. It says that current measures to increase patients' choice favour “the healthy, wealthy, and demanding.”

The report, from the Institute for Public Policy Research, a left-leaning think tank, argues that although “choice” is at the heart of the government's agenda, current policies favour middle class patients who have access to information and transport. It warns that this could lead to “a two-tier health service, where left-behind patients receive poorer quality of care.”

The report's authors found a wide range …
1123-182 Obesity does not attenuate the effectiveness of low-dose dalteparin in preventing venous thromboembolism in medically III patients
Authors: Nils Kucher, Alain Leizorovicz, Alexander T Cohen, Alexander G Turpie, Carl-Gustav Olsson, Paul T Vaitkus, Samuel Z Goldhaber
Journal: Journal of the American College of Cardiology (2004)
Vitamins and Hormones: Advances in Research and Applications. Volume X
Authors: R. S. Harris, G. F. Marrian, K. V. Thimann
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Uncommon Cause of Typical Cardiac Chest Pain
Authors: Martijn W. Smulders, Arthur W. F. du Mee, Bart de Vries, Peyman Sardari Nia
Journal: Circulation (2014)

A 64-year-old woman presented with typical angina dur- ing exercise for 2 weeks.An exercise treadmill test provoked similar chest pain and showed abnormal ST segments suggestive of myocardial ischemia during peak exercise.A prospectively ECG-triggered adaptive dual-source coronary computed tomography angiography ruled out coronary artery disease.Instead it demonstrated a nonenhanced clover-like structure attached to the left coronary cusp of the aortic valve with a close relation to the left coronary sinus (Figure ,A).Subsequent transthoracic and transesophageal echocardiography confirmed a very mobile mass with a stalk-like attachment to the cusp (Figure, B and Movie I in the online-only Data Supplement).A papillary fibroelastoma was considered highly likely, and urgent minimal invasive surgical removal of the tumor was performed to prevent thrombi-embolic complications and direct mechanical obstruction (Figure ,C).Histopathologic examination proved the diagnosis of papillary fibroelastoma (Figure ,D).After surgery, the patient was free of symptoms and remains so to date.This case illustrates that chest pain has a broad differential diagnosis including nonatherosclerotic coronary myocardial disease.Noninvasive imaging might clarify the underlying etiology in patients with chest pain.
Pregnancy after hysterotomy.
Authors: R F Heys
Journal: BMJ (1973)

The conclusion reached by Drs. W.M. Clow and A.C. Crompton (February 10, p. 321) that there is a substantial risk of uterine rupture in pregnancy after hysterotomy is reinforced by a case recently under my care. The patient, an unmarried 16-year-old, had had her 1st pregnancy terminated by abdominal hysterotomy at another hospital when she was 14 years of age. She was admitted to this hospital at 38 weeks' gestation (before the onset of labor) with signs and symptoms suggestive of intraabdominal hemorrhage. At laparotomy the upper end of the "classical" hysterotomy scar had ruptured completely and a portion of the underlying placenta was protruding through it. There was about 2 1/2 l of fluid and clotted blood in the peritoneal cavity. Caesarian supravaginal hysterectomy was performed and both mother and child survived, but the former required blood transfusions totaling 3 l. While fully agreeing with the authors' suggestion that hysterotomy should in general be eschewed unless sterilization is also performed, there may be circumstances in which hysterotomy is urgently indicated but sterilization is undesirable. In such cases, if the operation is performed after the 18th-20th week, the lower uterine segment is often sufficiently developed to permit evacuation through a transverse incision at this level. It would seem likely by analogy with classical and lower segment Casarean section incisions that the risk of uterine rupture in a subsequent pregnancy will be considerably reduced by this technique, which I now use whenever possible instead of the vertical upper segment incision usually employed for hysterotomy.
Rosemary Anne Smith
Authors: P. Sims
Journal: BMJ (2012)

Rosemary Anne Smith (nee Kemp) usually defied prognosis—in 1937 the senior mistress at St Paul’s School thought that she was unsuitable for medicine. She spent her working life in the services of clinical public health. Putting her age up she enlisted in the Women’s Royal Air Force (WRAF) in 1939 as a ranker; …
Abstract 146: MicroRNA-150 expression induces differentiation of myeloid leukemias
Authors: Valerie A. Morris, Ailin Zhang, Vivian G. Oehler
Journal: Cancer Research (2012)

Abstract Blocked myeloid differentiation is a major feature of chronic myeloid leukemia (CML) disease progression and acute myeloid leukemia (AML). Normal myeloid differentiation is a tightly controlled process involving the coordinated action of specific transcription factors, which are dysregulated by chromosomal translocations, DNA mutations, epigenetic changes, and aberrant gene and microRNA (miRNA) expression in leukemias. Previously, we identified decreased miR-150 expression in CML and AML cell lines and primary cells when compared to normal bone marrow, and determined miR-150 expression is decreased in CML by the Bcr-Abl fusion protein. Furthermore, lentiviral expression of miR-150 in AML cell lines and primary CML patient samples induced myeloid differentiation as detected by CD11b expression, morphologic differentiation, and colony forming ability in methylcellulose, both in the absence and presence of the differentiating agents. In this study, we elucidated the targets responsible for miR-150 induced differentiation. Expression of the validated miR-150 target MYB, a transcription factor involved in blocking differentiation in progenitor cells, was only decreased in miR-150 expressing cells in the presence of differentiating agent all-trans retinoic acid (ATRA). Furthermore, lentiviral overexpression of MYB lacking miR-150 binding sites in the 3′-UTR partially decreased the CD11b expression in the presence and absence of ATRA in both control and miR-150 expressing HL60 cells. These results suggest additional miR-150 targets are involved in differentiation besides MYB. To identify additional miRNA-150 targets, we profiled changes in mRNAs associated with the RNA-induced silencing complex (RISC) using RNA-immunoprecipitation of Ago2 followed by microarray gene expression profiling in miR-150 versus control HL60 cells. Furthermore, although almost all functional investigations have focused on the mature strand, we have found that miR-150 and its partner star strand miR-150* are expressed at almost equal levels in normal myeloid hematopoietic cells, and are investigating the individual contributions of their separate targets in induction of differentiation. In conclusion, miR-150 expression promotes myeloid differentiation through targeting transcription factor MYB and additional targets, while downregulation of miR-150 in myeloid leukemias contributes to the block in differentiation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 146. doi:1538-7445.AM2012-146
Scintimaging of Bronchopleural Fistula A Simple Method of Diagnosis
Authors: RICHARD E. LOWE, ASLAM R. SIDDHQUI
Journal: Clinical Nuclear Medicine (1984)

A bronchopleural fistula in a patient with empyema was demonstrated by xenon-133 ventilation lung scanning. Because of its ease and simplicity, the ventilation study should be one of the first diagnostic tests performed when bronchopleural fistula is suspected.
Influence of reversible segmental left ventricular dysfunction on heart period variability in patients with one-vessel coronary aetery disease
Authors: Domenico Bonaduce, Mario Petretta, Federico Piscione, Ciro Indolfi, Marie Louise Migaux, Valter Bianchi, Nicola Esposito, Fortunato Marciano, Massimo Chiariello
Journal: Journal of the American College of Cardiology (1994)
General practitioners' views on quality specifications for "outpatient referrals and care contracts".
Authors: A Bowling, B Jacobson, L Southgate, J Formby
Journal: BMJ (1991)

OBJECTIVE--To ascertain general practitioners9 views about which quality specifications should be included in contracts for hospital care. DESIGN--In depth interview study and postal survey. SETTING--General practitioners in City and Hackney Health District. SUBJECTS--Fourteen doctors were interviewed in depth; 77 of 131 doctors (59%) returned postal questionnaires. MAIN OUTCOME MEASURE--Rating of listed quality specifications. RESULTS--The most popular items which doctors thought should be included in contracts by April 1991 related to the availability of patients9 notes in outpatient clinics, respect shown to general practitioners in telephone communications with hospital doctors, supply of medicines after discharge, patient management plans for general practitioners, the earlier arrival of discharge slips, the type of hospital doctor to see new outpatients, and the unnecessary duplication of investigations. CONCLUSIONS--A high premium was attached by general practitioners to effective organisation, effective communication between primary and secondary sources of care, and effective communication with patients.
SOME QUESTIONS RELATING TO GLAUCOMA.
Authors: ALEX. W. STIRLING
Journal: JAMA (1896)

I propose to bring forward for discussion certain parts of the subject of glaucoma, which though far from novel, yet appear to merit, from their importance and the still divergent views concerning them, a constantly recurring investigation. These questions are: Is glaucoma always preceded by papillitis? Are certain doubtful cases of chronic glaucoma with an apparently normal condition of the anterior segment of the eye, unaccompanied by any sign of spinal and cerebral disease, but showing what is known as the true glaucoma cup; are these really glaucoma, or are they optic atrophy? Should all cases of primary glaucoma be operated upon? What is the cause of the cataract which occasionally appears in eyes which have just undergone operation for glaucoma? <h3>Question 1.</h3> —Those who hold that papillitis is a constant accompaniment of the early symptoms of glaucoma should be divided into two classes, viz., those who assert that it
GMSC's advice on intrapartum care is unhelpful
Authors: J. Bradbrook, M. Carmi, J. Danby, R. Fawdry, J. Fletcher, D. Gill, A. Jackson-Baker, D. Jewell, M. McKenzie, A. Noble, R. Porter, B. Seaman, L. Smith, G. Young
Journal: BMJ (1996)

screening would raise, or the costs of providing a service for women who would not consider termination of pregnancy.We may be able to screen, and might potentially be able to do it cost effectively, but should we do it and, if so, how?
Whose Story Is It, Anyway?
Authors: Lisa Simon
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Secretion of Prohormone of B-Type Natriuretic Peptide, proBNP 1-108 , Is Increased in Heart Failure
Authors: Lisa C. Costello-Boerrigter, Harald Lapp, Guido Boerrigter, Amir Lerman, Alexander Bufe, Fima Macheret, Denise M. Heublein, Catherine Larue, John C. Burnett
Journal: JACC Heart Failure (2013)
Bites by foreign venomous snakes in Britain.
Authors: H A Reid
Journal: BMJ (1978)

In 1970-7 17 people in Britain were the victims of 32 bites by foreign venomous snakes. Crotalus atrox caused eight of these bites, Bitis arietans five, and the remaining 19 bites were caused by 12 different species. All the victims were bitten while handling the snake, and 24 bites were incurred by private individuals in their own homes. Poisoning was negligible in 17 of the 32 bites but life-threatening in at least two cases. Thus in the early stages snake bite may be unpredictable as a clinical problem. All victims of snake bite should be observed for at least 12 hours to assess the severity of poisoning and to ensure rational treatment. Local necrosis developed in six cases and resulted in prolonged illness in five of these cases; local incision was carried out and many have been a casual factor. Comprehensive stocks of antivenoms for treating bites by foreign venomous snakes are held by the National Health Services in Liverpool and London. Antivenom is indicated (a) for potentially serious systemic poisoning, as evidenced by hypotension, electrocardiographic changes, neurtrophilia, and acidosis (after viper or elapid bites), abnormal bleeding or non-clotting blood after viper bites; and ptosis or glossopharyngeal palsy after elapid bites; and (b) for bites from snakes whose venom causes local necrosis, to prevent or minimise this unpleasant complication. For effective antivenom treatment intravenous infusion is mandatory.
An in vivo model of human small intestine using pluripotent stem cells
Authors: Carey L Watson, Maxime M Mahe, Jorge Múnera, Jonathan C Howell, Nambirajan Sundaram, Holly M Poling, Jamie I Schweitzer, Jefferson E Vallance, Christopher N Mayhew, Ying Sun, Gregory Grabowski, Stacy R Finkbeiner, Jason R Spence, Noah F Shroyer, James M Wells, Michael A Helmrath
Journal: Nature Medicine (2014)
Organic meat products contaminated with carcinogenic herbicide
Authors: A. Tuffs
Journal: BMJ (2002)

A storage depot in east Germany has been identified as the source of several hundred tonnes of organic animal feed contaminated with the herbicide nitrofen.

Before the reunification of Germany in 1990, the depot, in Mecklenburg-West Pomerania, was used for storing the herbicide. The depot had apparently not been properly cleaned when it was converted to store corn feed for animals on organic farms.

Since the discovery by a baby food manufacturer of nitrofen …
Case 45-1966
Authors: Charles A. Sanders, Robert E. Scully
Journal: New England Journal of Medicine (1966)

Presentation of CaseFirst admission. A fifty-eight-year-old man of Latvian birth was admitted to the hospital because of pain in the chest.Elicitation of the history was limited by a language barrier. Thirty-five years previously he spent six months in a sanatorium for treatment of tuberculosis. Eight years before admission he entered the hospital because of a perforated duodenal ulcer; a subtotal gastrectomy was performed. X-ray films of the chest taken at that time (Fig. 1) showed linear and nodular densities in both pulmonary apexes and small bullae in the upper lobes; the heart was of normal size. He had . . .