Thymoma and Erythroid Hypoplasia with Carcinoma of the Pancreas, Bronchiolar Hyperplasia, and Pulmonary Tuberculosis
Authors: MICHAEL LIPA
Journal: Annals of Internal Medicine (1966)

Case Studies1 September 1966Thymoma and Erythroid Hypoplasia with Carcinoma of the Pancreas, Bronchiolar Hyperplasia, and Pulmonary TuberculosisMICHAEL LIPA, M.D., DOROTHY C. H. LEY, M.D., F.R.C.P.(C), F.A.C.P.MICHAEL LIPA, M.D.Search for more papers by this author, DOROTHY C. H. LEY, M.D., F.R.C.P.(C), F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-3-541 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeoplasms of the thymus are uncommon, and acquired pure red cell hypoplasia, or aplasia, is rare. However, about 50% of the latter have been associated with benign thymomas.Approximately 40 cases of acquired pure red cell hypoplasia associated with thymoma have been reported in the past 35 years (1-4). This obscure syndrome was coincidental with carcinoma of the breast in two patients (5, 6). In addition, some thymomas without the anemia present were found with other neoplasms. These included carcinomas of lung, breast (7), tongue, thyroid, and rectum, bronchogenic adenoma, and fibrosarcoma of the arm (8).The syndrome of thymoma...References1. SCHMIDKIELYHARRISONBAYRDPEASE JRJMEGEDGL: Thymoma associated with pure red cell agenesis. Review of literature and report of 4 cases. Cancer 18: 216, 1965. CrossrefMedlineGoogle Scholar2. ROLAND AS: The syndrome of benign thymoma and primary aregenerative anemia; an analysis of forty-three cases. Amer. J. Med. Sci. 247: 719, 1964. CrossrefMedlineGoogle Scholar3. KOUGHBARNES RHWT: Thymoma associated with erythroid aplasia, bullous skin eruption, and the lupus erythematosus cell phenomenon: report of a case. Ann. Intern. Med. 61: 308, 1964. LinkGoogle Scholar4. NORMAN AG: Thymic tumors with red cell aplasia. Thorax 20: 193, 1965. CrossrefMedlineGoogle Scholar5. CLARKSONPROCKOP BDJ: Aregenerative anemia associated with benign thymoma. New Eng. J. Med. 259: 253, 1958. CrossrefMedlineGoogle Scholar6. GREEN P: Aplastic anemia associated with thymoma: report of two cases. Canad. Med. Ass. J. 78: 419, 1958. MedlineGoogle Scholar7. LEGGBRADY MAWJ: Pathology and clinical behavior of thymomas. A survey of 51 cases. Cancer 18: 1131, 1965. CrossrefMedlineGoogle Scholar8. LATTES R: Thymoma and other tumors of the thymus. An analysis of 107 cases. Cancer 15: 1224, 1962. CrossrefGoogle Scholar9. WINTROBE MM: Clinical Hematology, 5th ed. Lea & Febiger, Philadelphia, 1961, pp. 576, 580. Google Scholar10. SAIDIWALLERSTEINAGGLER PROPM: Effect of chloramphenicol on erythropoiesis. J. Lab. Clin. Med. 57: 247, 1961. MedlineGoogle Scholar11. VERSTRAETEVERMYLENVERMYLENVANDERBROUCKE MCJJ: Excessive consumption of blood coagulation components as a cause of hemorrhagic diathesis. Amer. J. Med. 38: 899, 1965. CrossrefMedlineGoogle Scholar12. KREVANSJACKSON JRDP: Hemorrhagic disorder following massive whole blood transfusions. JAMA 159: 171, 1955. CrossrefMedlineGoogle Scholar13. DIAMONDALLENMAGILL LKDMFB: Congenital (erythroid) hypoplastic anemia. A 25-year study. Amer. J. Dis. Child. 102: 403, 1961. CrossrefMedlineGoogle Scholar14. SCHMIDKIELYPEASEHARGRAVES JRJMGLMM: Acquired pure red cell agenesis. Report of 16 cases and review of the literature. Acta Haemat. (Basel) 30: 255, 1963. CrossrefMedlineGoogle Scholar15. WHITWELL F: Tumorlets of the lung. J. Path. Bact. 70: 529, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto, Ontario,From the Departments of Pathology and Hematology, the Toronto Western Hospital, Toronto, Ontario, Canada.Requests for reprints should be addressed to Michael Lipa, M.D., Department of Pathology, Toronto Western Hospital, Toronto 2B, Ontario, Canada. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySynchronous extrathoracic metastasis of thymoma masquerading as fibrosing mediastinitis: Initial diagnosis made by fine needle aspiration and core biopsy of a pancreatic massAplastische Anämie bei ThymomEndokrinologie in der KinderheilkundeBenign thymoma and erythroid hypoplasia. Thirteen-year “cure” following thymectomyMarrow-Suppressing Factors in the Blood in Pure Red-Cell Aplasia, Thymoma and Hodgkin's DiseaseImmunological Aspects of Neoplasia 1 September 1966Volume 65, Issue 3Page: 541-548KeywordsAnemiaHemorrhageLungsPancreasPhotographyRectumThymomaThymusThyroid carcinomaTongue Issue Published: 1 September 1966 PDF downloadLoading ...