tbuckley/cabot-search huggingface dataset:
The Work of Mr. Robert Jones.
Authors: Henry Ling Taylor
Journal: JAMA (1903)

Liverpool, July, 1903. <h3>To the Editor:</h3> Liverpool is known to everyone interested in the treatment of deformities as the home of the late Hugh Owen Thomas, whose original and practical mind has left an indelible impression on surgical technics. Carrying on the work in the same building, and inspired by at least an equal enthusiasm, his gifted nephew and successor, Mr. Robert Jones, is conducting one of the most remarkable orthopedic services in existence. This work is well known to specialists, but must be seen to be appreciated, and as it was the writer's privilege, through Mr. Jones' courtesy, to observe the work for several days, these impressions have been jotted down with the feeling that it deserved to be more widely known among the profession at large. Mr. Jones begins his day after an early breakfast by visiting his patients at their homes or in the various private hospitals
Childhood high-risk acute lymphoblastic leukemia in first remission: results after chemotherapy or transplant from the AIEOP ALL 2000 study
Authors: Valentino Conter, Maria Grazia Valsecchi, Rosanna Parasole, Maria Caterina Putti, Franco Locatelli, Elena Barisone, Luca Lo Nigro, Nicola Santoro, Maurizio Aricò, Ottavio Ziino, Andrea Pession, Anna Maria Testi, Concetta Micalizzi, Fiorina Casale, Marco Zecca, Gabriella Casazza, Paolo Tamaro, Gaetano La Barba, Lucia Dora Notarangelo, Daniela Silvestri, Antonella Colombini, Carmelo Rizzari, Andrea Biondi, Giuseppe Masera, Giuseppe Basso
Journal: Blood (2014)
Diagnostic and Prognostic Testing in Pneumonia
Authors: Joshua P. Metlay, Michael J. Fine
Journal: Annals of Internal Medicine (2003)

Letters2 December 2003Diagnostic and Prognostic Testing in PneumoniaJoshua P. Metlay, MD, PhD and Michael J. Fine, MD, MScJoshua P. Metlay, MD, PhDFrom Center for Health Equity Research and Promotion, Veterans Affairs Medical Center, Philadelphia, PA 19104; and Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240.Search for more papers by this author and Michael J. Fine, MD, MScFrom Center for Health Equity Research and Promotion, Veterans Affairs Medical Center, Philadelphia, PA 19104; and Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-11-200312020-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree that a key explanation for the observed poor accuracy of the physical examination in the diagnosis of community-acquired pneumonia is the documented level of poor interobserver agreement among clinicians. We also agree that studies have suggested that the level of agreement among clinicians does not improve as a function of years of training. What remains unclear, however, is whether more expanded effort to train undergraduate and graduate medical students in the skills of bedside examination will yield improved performance characteristics for these diagnostic tests. There is little reason to undertake educational efforts designed to improve the ... Author, Article, and Disclosure InformationAffiliations: From Center for Health Equity Research and Promotion, Veterans Affairs Medical Center, Philadelphia, PA 19104; and Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTesting Strategies in the Initial Management of Patients with Community-Acquired Pneumonia Joshua P. Metlay and Michael J. Fine Diagnostic and Prognostic Testing in Pneumonia Bernard M. Karnath and Join Y. Luh Metrics 2 December 2003Volume 139, Issue 11Page: 955KeywordsGraduate medical educationPneumoniaSpecificityUndergraduates ePublished: 2 December 2003 Issue Published: 2 December 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Climate change and infectious diseases in Europe: leishmaniasis and its vectors in Spain
Authors: Francisco Morillas-Márquez, Joaquina Martín-Sánchez, Victoriano Díaz-Sáez, Sergio Barón-López, Manuel Morales-Yuste, Fernando Alves de Lima Franco, Maria Cesárea Sanchís-Marín
Journal: The Lancet Infectious Diseases (2010)
Four Cases of Pneumococcal Peritonitis
Authors: C. Noon
Journal: BMJ (1941)

Acute pneumococcal peritonitis is an uncommon disease.The use of surgery with the administration of sulphapyridine illustrates an advance which has taken place in the treatment of this type of peritonitis during the last few years.Before the introduction of Felton's type anti- pneumococcal serum and sulphapyridine, pneumococcal peritonitis was an extremely fatal disease.Following the administration of the serum a certain number of these
Surgery of the ascending aorta: five years' experience at a regional cardiac centre.
Authors: P G Reasbeck, J L Monro, J K Ross, N Conway, A M Johnson
Journal: Thorax (1979)

Between 1972 and 1978, 31 patients underwent replacement of the ascending aorta, with or without aortic valve surgery, at the Wessex Regional Cardiac Centre. The commonest indications for operation were aneurysmal dilatation of the ascending aorta causing aortic regurgitation and acute dissection of the ascending aorta. Eleven of the 31 patients had features of Marfan's syndrome. The overall hospital mortality was 19.4%, a figure comparable with those reported in other series; ventricular failure secondary to ischaemia during operation was the commonest cause of death. The long-term symptomatic results were excellent, except in the two patients who underwent resuspension of the aortic valve for aortic regurgiation associated with acute dissections. For aneurysms of the ascending aorta with associated aortic regurgitation, replacement of the valve and ascending aorta with a combined valve prosthesis and synthetic tube graft, with reimplantation of the coronary ostia, is the procedure of choice if the aortic valve ring is diseased. Experience to date indicates that replacement of the ascending aorta and aortic valve with separate prostheses, leaving the coronary ostia undisturbed, is a satisfactory alternative provided the aortic annulus is of suitable size and quality; this is more likely to be the case in dissections than in aneurysmal dilatation of the ascending aorta. Replacement of the ascending aorta may also be indicated in some cases of dilatation of the ascending aorta secondary to aortic valve disease if the aortic wall is unusually thin.
Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study
Authors: Sant Chawla, Robert Henshaw, Leanne Seeger, Edwin Choy, Jean-Yves Blay, Stefano Ferrari, Judith Kroep, Robert Grimer, Peter Reichardt, Piotr Rutkowski, Scott Schuetze, Keith Skubitz, Arthur Staddon, David Thomas, Yi Qian, Ira Jacobs
Journal: The Lancet Oncology (2013)
Foscarnet in the Treatment of Cytomegalovirus Retinitis in Acquired Immune Deficiency Syndrome
Authors: Phuc Lehoang, Brigitte Girard, Martin Robinet, Patricia Marcel, Lydie Zazoun, Sophie Matheron, Willy Rozenbaum, Christine Katlama, Isabelle Morer, John O. Lernestedt, Henry Saraux, Yves Pouliquen, Marc Gentilini, Françoise Rousselie
Journal: Ophthalmology (1989)
Leukocyte Alkaline Phosphatase
Authors: MARTIN H. STEINBERG
Journal: Annals of Internal Medicine (1974)

Comments and Correction1 August 1974Leukocyte Alkaline PhosphataseMARTIN H. STEINBERG, M.D., F.A.C.P.MARTIN H. STEINBERG, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-2-274_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Rosner and Karayalcin (1) have confirmed the work of Wajima and Kraus (2), who first noted low leukocyte alkaline phosphatase activity in the granulocytes of individuals with sickle-cell anemia. They believed this finding was unusual in that the opposite would be expected; an elevated leukocyte alkaline phosphatase level because of the chronic stressful state of persons with sickle-cell disease (1).The cellular content of leukocyte alkaline phosphatase depends partly on the degree of maturity of the granulocyte. This enzyme first becomes evident during the myelocyte stage of development, when the specific neutrophilic granules appear, and its quantity...References1. ROSNERKARAYALCIN FG: Decreased leukocyte alkaline phosphatase activity in sickle-cell anemia (letter). Ann Intern Med 80:668-669, 1974 LinkGoogle Scholar2. WAJIMAKRAUS TA: Low leukocyte alkaline phosphatase activity in sickle cell anemia. J Lab Clin Med 72:980-984, 1968 MedlineGoogle Scholar3. BAINTONULLYOTFARQUHAR DJM: The development of neutrophilic polymorphonuclear leukocytes in human bone marrow. J Exp Med 134:907-934, 1971 CrossrefMedlineGoogle Scholar4. BOGGSHYDESRODES DFC: An unusual pattern of neutrophil kinetics in sickle cell anemia. Blood 41:59-65, 1973 CrossrefMedlineGoogle Scholar5. PEDERSENHAYHOE BF: Cellular changes in chronic myeloid leukaemia. Br J Haematol 21:251-256, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARTIN H. STEINBERG, M.D., F.A.C.P.Affiliations: Special Hematology Laboratory VA Hospital University of Mississippi School of Medicine Jackson, Mississippi 39216 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1974Volume 81, Issue 2Page: 274-274KeywordsAnemiaEnzymesGranulocytesPhosphatases ePublished: 1 December 2008 Issue Published: 1 August 1974 PDF downloadLoading ...
Median Neuropathy (Carpal-Tunnel Syndrome) in Acromegaly
Authors: J. DESMOND O'DUFFY
Journal: Annals of Internal Medicine (1973)

Of 100 acromegalic patients, 35 had carpal-tunnel syndrome. All but 1 of the 35 had active acromegaly, as judged by clinical and laboratory methods. Of the 100 patients, 63 had active acromegaly, 17 had inactive acromegaly, and 20 had acromegaly that was of indeterminate activity. Statistical analysis showed that carpal-tunnel syndrome in acromegaly denotes ongoing pituitary overactivity (P < 0.001). In every patient in whom pituitary treatment was successful, whether by irradiation (three of nine) or surgery (five of six), the syndrome was abolished completely. Although failure to correct hypersomatotropism usually led to continuation of this syndrome, the latter sometimes cleared despite residual pituitary overactivity. Therefore, whereas carpal-tunnel syndrome in acromegaly is a useful indicator of active disease, its disappearance does not necessarily indicate that growth hormone output has returned to normal.
Exercise Intensity and Longevity in Men
Authors: Marco Pahor
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The article by Dr Lee and colleagues<sup>1</sup>on intensity of physical activity and longevity provides additional evidence that physical activity is associated with improved survival. Some points, however, may require further clarification. Different criteria were used to categorize the energy expenditure in specific analytical approaches. Quintiles were shown in Table 1 and in the total energy expenditure multivariate analysis (range, &lt;2524 to &gt;13142 kJ/wk), eight categories were used when analyzing the age-adjusted associations with mortality (range, &lt;2100 to &gt; 14 700 kJ/wk, Table 2), and five categories were used in the multivariate models (range, &lt;630 to &gt;6300 kJ/wk, Tables 3 and 4). Consequently, it is impossible to match the results across the tables. This may confuse readers, and the reasons for presenting the data in such different groupings are not known. Vigorous, but not nonvigorous, physical activities were associated with longevity. From a practical point of
Prevalence of Diabetes in Greater Beirut
Authors: Kamal I. Hirbli, Mayssa A. Jambeine, Hanna B. Slim, Wadad M. Barakat, Richard J. Habis, Zelia M. Francis
Journal: Diabetes Care (2005)

High rates of diabetes have been observed among Arab populations in the Middle East (1). We aimed to determine the prevalence of previously diagnosed and undiagnosed diabetes in Greater Beirut, which includes Administrative Beirut and its suburban part of Mount Lebanon. This part of Lebanon is home to 53.6% of the population and represents a mixture of urban and rural areas with different socioeconomic classes.

A multistage random probability sample was devised using the population distribution suggested by the Lebanese Central Administration of Statistics. Despite a minor and insignificant deviation, the quota that best represents Greater Beirut was achieved.

A research team …
Monitoring the acute phase response.
Authors: A. G. Freeman
Journal: BMJ (1989)

Breach of this standard is ipso facto malpractice.Furthermore, responsibility for professional acts rests with the actUal treatihg physician and may not be trahsferted to leiployers, government pro- gramnmes, hospital officials or commnittees, chiefs of service, comftiiWs §onets, atid the like.We have no professional dMty to any such party; our obligatlon is solely t6 out patienits.Who, if anyone, will pay to have our orders carried out must remain an entirely separate ques- tion.ttt Professor Willatins's dangerous solution is to comingle these Issues, thus muddying the clatity of professional thought.tf, constr4ined by bUdgets and policies, we fail to tell our pitients Whit We think is best for them they'll never khow and will never be able to act in their own ititerest.
Eric Sherwood-Jones
Authors: E. Sherwood-Jones
Journal: BMJ (2012)

Eric Sherwood-Jones was a pioneer of intensive care in the UK. He also made important contributions to clinical science. Despite this specialisation he insisted that he was one of the last general physicians. He was the fourth son of Albert Jones, DSO, MC, MD, DPH, and Ann Ivey Cooke. The family settled in the industrial town of Widnes and were committed to public health and industrial medicine. After qualifying, Eric Sherwood-Jones worked for the brilliant diagnostician and teacher Professor Henry Cohen (later Lord Cohen of Birkenhead), an experience that set him on a career as a physician. After gaining MRCP 18 months after qualification, Sherwood-Jones extended his training by studying experimental medicine at the Liverpool School of Tropical Medicine. His …
Endoscopically Assisted Video Capsule Endoscopy of the Small Bowel in Patients with Functional Gastric Outlet Obstruction
Authors: S. Hollerbach, K. Kraus, J. Willert, K. Schulmann, W. Schmiegel
Journal: Endoscopy (2003)

Since the introduction in 2001 of M2A video capsule imaging of the small bowel in humans, this technique has been used increasingly in patients with disorders of the small bowel. In particular the assessment of small obscure gastrointestinal bleeding sources and the detection of shallow inflammatory lesions in the small bowel, have been greatly facilitated by this novel imaging procedure. We report two cases of patients with obscure gastrointestinal bleeding, in whom normal passage of the capsule through the antroduodenal junction was inhibited. This was because of delayed gastric emptying in both patients, which was presumably caused by functional impairment of pyloric motility. To facilitate capsule transport into the small bowel, after swallowing the capsule each patient underwent unsedated upper gastrointestinal endoscopy during which the capsule was grasped with a polypectomy snare, directly transported through the pylorus, and finally released upon arrival in the second portion of the duodenum. Capsule recordings revealed the source of bleeding in both patients and their medical or surgical treatment was subsequently escalated. Capsule imaging of the small bowel facilitated by esophagogastroduodenoscopy (EGD) is safe, and can be applied when patients have functional disorders of pyloric motility.
THE LENS AS SEEN WITH THE GULLSTRAND SLIT LAMP AND CORNEAL MICROSCOPE
Authors: ARTHUR J. BEDELL
Journal: JAMA (1924)

The Gullstrand slit lamp, combined with the corneal microscope, has made it possible for us to study the lens in more minute detail than ever before. The normal and pathologic changes in capsule and cortex heretofore difficult of examination are now more easily interpreted. <h3>THE CAPSULE</h3> The anterior capsule consists of irregular quadrate cells which look like a tile mosaic; the surface may be smooth but it is most often rough, giving the impression we get from a cocain dryness of the cornea. At other times, many reflections from its surface recall craters on the moon. On the capsule may be found pigment deposits; star cells, rounded masses or lines. Remnants of the pupillary membrane may show as a distinct grayish-white accretion from which fibers pass to the iris, or as broad, white bands which come from behind the iris and often carry rounded pigment plaques. The capsule may become
Detection of Active Bleeding From Ruptured Aortic Aneurysm by Emergency Radionuclide Angiography
Authors: HISASHI BUNKO, HIKARU SETO, NORIHISA TONAMI, KINICHI HISADA
Journal: Clinical Nuclear Medicine (1978)

Radionuclide angiography of the abdominal aorta provides hemodynamic information of the kidneys, aorta and aneurysm as well as the location and extent of aneurysm. Visualization of early abnormal activity in the pelvic region simultaneously with iliac artery visualization is thought to be a specific finding of active bleeding from a ruptured aneurysm of the abdominal aorta.
CCL21 is associated with fatal outcomes in chronic heart failure: data from CORONA and GISSI‐HF trials
Authors: Thor Ueland, Ståle H. Nymo, Roberto Latini, John J.V. McMurray, John Kjekshus, Arne Yndestad, Alessandro Fucili, Aurelia Grosu, Serge Masson, Aldo P. Maggioni, Lars Gullestad, Pål Aukrust
Journal: European Journal of Heart Failure (2013)
288 INFRADURE: SUSTAINED DELIVERY OF INTERFERON-ALPHA (IFNα) IN SCID MICE BY IMPLANTED IFNA SECRETING DERMAL BIOPUMPS
Authors: B. Stern, E. Shoshani, A. Pearlman, P. Ng, R. Meari, H. Goltzmann, A. Rimler, A. Okun, H. Bookay, T. Gibly, E. Keeffe
Journal: Journal of Hepatology (2010)
Midline Catheterization in Hospitalized Patients
Authors: A.J. Moorcroft
Journal: Annals of Internal Medicine (1996)

Letters15 October 1996Midline Catheterization in Hospitalized PatientsA.J. Moorcroft, MD, R. Niven, MD, and S. Quantrill, MDA.J. Moorcroft, MDWythenshawe Hospital, Manchester, M23 9LT, United KingdomSearch for more papers by this author, R. Niven, MDWythenshawe Hospital, Manchester, M23 9LT, United KingdomSearch for more papers by this author, and S. Quantrill, MDWythenshawe Hospital, Manchester, M23 9LT, United KingdomSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-8-199610150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Mermel and associates [1] raised important safety issues in their study of the risk of midline catheterization. We have used approximately 500 Landmark midline catheters in our unit during the past 4 years and have seen seven adverse reactions in five adults with cystic fibrosis. In all cases, patients had rapid onset of dyspnea within minutes of insertion and either before or after the line was flushed. We noted four cases of erythematous skin reaction and one case of angioedema. Other reactions seen on one or more occasions were nausea, vomiting, wheeze, cough, tachycardia, and rigor. Cyanosis ...References1. Mermel LA, Parenteau S, Tow SM. The risk of midline catheterization in hospitalized patients. A prospective study. Ann Intern Med. 1995; 123:841-4. Google Scholar2. Maki DG. Reactions associated with midline catheters for intravenous access [Editorial]. Ann Intern Med. 1995; 123:884-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: Wythenshawe Hospital, Manchester, M23 9LT, United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRe‐evaluating expanding intravenous catheters in medical practiceAnaphylaxis and anaphylactoid reactions associated with the insertion of peripherally inserted central catheters: A multiyear comparative retrospective cohort study 15 October 1996Volume 125, Issue 8Page: 695KeywordsAdverse reactionsCatheterizationCathetersNauseaPulmonary diseasesSafetySafety studiesSkin reactionTachycardiaVomiting Issue Published: 15 October 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Cardiac Resuscitation — When Is Enough Enough?
Authors: Gordon A. Ewy
Journal: New England Journal of Medicine (2006)

Cardiac arrest is a leading cause of death in the United States.1 In spite of periodic updates of the Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care of the American Heart Association (AHA) (hereafter referred to as the AHA guidelines), survival rates are dismal in the absence of early defibrillation and have remained essentially unchanged for decades.1,2 In large cities in the United States, overall survival of out-of-hospital arrest of presumed cardiac cause is about 1 percent — approximately the rate that has been suggested to define medical futility.2,3 The cost of providing emergency medical services (EMS) to . . .
Abstract 4987: Non-targeting siRNA induces NPGPx expression to cooperate with exoribonuclease XRN2 for releasing the stress
Authors: Pei-Chi Wei
Journal: Cancer Research (2012)

Abstract Short interfering RNAs (siRNAs) target specific mRNAs for their degradation mediated by RNA-induced silencing complex (RISC). Persistent activation of siRNA-RISC frequently leads to non-targeting toxicity. However, how cells mediate this stress remains elusive. In this communication, we found that the presence of non-targeting siRNA selectively induced the expression of an ER-resident protein, non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx), but not other ER-stress proteins including GRP78, Calnexin, and XBP1. Cells suffering from constant non-targeting siRNA stress grew slower and prolonged G1 phase, while NPGPx-depleted cells accumulated mature non-targeting siRNA and underwent apoptosis. Upon the stress, NPGPx covalently bound to exoribonuclease XRN2, facilitating XRN2 to remove accumulated non-targeting siRNA. These results suggest that NPGPx serves as a novel responder to non-targeting siRNA-induced stress in facilitating XRN2 to release the non-targeting siRNA accumulation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4987. doi:1538-7445.AM2012-4987