tbuckley/cabot-search huggingface dataset:
The Lesions of Sarcoidosis
Authors: Frederick A. J. Kingery
Journal: JAMA (1965)

Specificn be found in more than a third of patients with systemic sarcoidosis. These lesions represent dermal sarcoid granulomas and are capable of wide variation in clinical appearance, even though the microscopic picture is constant. Examination with eye and hand (for the infiltrate is often more easily palpated than seen) must be followed with microscopic verification.  Jonathan Hutchinson described cutaneous sarcoid almost 70 years ago under the title of Mortimer's malady. Hutchinson was not aware that these lesions on the skin reflected a systemic problem.  Accurate diagnosis of sarcoidosis can be facilitated by the examination of material easily obtained from cutaneous lesions. Every patient with suspected sarcoidosis should be carefully examined for possible diagnostic dermal granulomas.
New approaches to conversion hysteria
Authors: P. W Halligan
Journal: BMJ (2000)

Patients with hysterical conversion, now called conversion disorder by the main US psychiatric glossary,1 often present with striking neurological symptoms such as weakness, paralysis, sensory disorders, or memory loss, in the absence of any pathology that could be responsible. Most patients will be referred to a neurologist or psychiatrist after consulting their family doctor.

As many as 4% of those attending neurology outpatient clinics in the United Kingdom have been estimated to have conversion disorders.2 Similar rates have been reported for both in and outpatient clinics in other European countries.

Empirical research on hysterical conversion has lagged behind theoretical speculation. Recent advances in functional imaging (positron emission tomography scanning) and cognitive neuropsychology have, however, made the field more amenable to investigation.3 Key clinical and theoretical problems remain over case definition and differential diagnosis, the psychological mechanisms underlying conversion hysteria, and how patients are best managed.

Despite attempts over the past century to abolish and reinstate the condition by using different labels, conversion hysteria continues to attract controversy. …
Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis
Authors: Hoon-Ki Sung, Kyung-Oh Doh, Joe Eun Son, Jin Gyoon Park, Yunui Bae, Soojeong Choi, Seana Mary Lunney Nelson, Rebecca Cowling, Kristina Nagy, Iacovos P. Michael, Gou Young Koh, S. Lee Adamson, Tony Pawson, Andras Nagy
Journal: Cell Metabolism (2013)
Repeated dipyridamole administration enhances collateral-dependent flow and regional function during exercise. A role for adenosine.
Authors: J D Symons, E Firoozmand, J C Longhurst
Journal: Circulation Research (1993)

Two main hypotheses concerning the mechanisms responsible for coronary collateral growth suggest the involvement of chemical or mechanical factors. Since we recently demonstrated that the development of the coronary collateral circulation is not closely related to the extent or duration of myocardial ischemia, we hypothesized that chronic repeated vasodilation and increased myocardial blood flow using dipyridamole would enhance collateral development in miniswine with an ameroid-occluded left circumflex coronary artery (LCx). Two days after surgical instrumentation, the animals received dipyridamole (n = 9), diltiazem as an adenosine-independent vasodilator (n = 8), or control vehicle (n = 7) 90 minutes per day, 5 days per week for 8 weeks. At 5 and 8 weeks, transmural blood flow and systolic wall thickening were measured during infusion of dipyridamole, diltiazem, or vehicle. Transmural blood flow increased similarly in the LCx and nonoccluded regions at 30 and 60 minutes during infusion of either vasodilator. Thus, we believe that similar mechanical stimulation resulted from dipyridamole and diltiazem infusion. There was no change in blood flow during administration of the vehicle. Systolic wall thickening in the collateral-dependent region was not altered by infusion of dipyridamole, diltiazem, or vehicle. Therefore, both vasodilators increased blood flow without eliciting ischemia. After 8 weeks of repeated treatment with each pharmacological agent, at least 24 hours after the last drug infusion, near maximal physiological capacity of the coronary collateral vessels was assessed during treadmill running (approximately 240 beats per minute). Transmural myocardial blood flow ratios, expressed as flow in the LCx divided by flow in the nonoccluded region of the left ventricle, were similar at rest for animals treated with dipyridamole (0.90 +/- 0.03), diltiazem (0.97 +/- 0.05), and control vehicle (0.89 +/- 0.02). However, collateral-dependent myocardial blood flow during exercise was greater (P &lt; .05) in the dipyridamole-treated animals (0.78 +/- 0.04) than in either diltiazem-treated (0.63 +/- 0.09) or vehicle-treated (0.62 +/- 0.02) animals. LCx systolic wall thickening at rest was similar in animals treated with dipyridamole (44.4 +/- 6.3%), diltiazem (42.2 +/- 3.0%), and control vehicle (38.1 +/- 2.8%). During exercise, however, myocardial function in the collateral-dependent region was greater (P &lt; .05) in the dipyridamole-treated (39.2 +/- 5.2%) compared with diltiazem-treated (23.9 +/- 4.0%) and vehicle-treated (26.9 +/- 2.9%) animals.(ABSTRACT TRUNCATED AT 400 WORDS)
Simultaneous inhibition of integrin alpha V beta 3 potentiates the effect of platelet glycoprotein IIb/IIIa antagonism on infarct size reduction in acute coronary thrombosis
Authors: Tadamichi Sakuma, Ibrahim Sari, Craig N. Goodman, Jonathan R. Lindner, Alexander L. Klibanov, Howard Leong-Poi, Sanjiv Kaul
Journal: Journal of the American College of Cardiology (2003)
Royal college calls on hospitals to tackle emergency department "exit block" to hospital beds
Authors: J. Wise
Journal: BMJ (2015)

“Exit block,” when patients cannot be moved from a hospital emergency department into a hospital bed, is a growing problem that needs to be tackled urgently, the Royal College of Emergency Medicine has said.

Its report says that exit block raises patient mortality, increases patients’ length of stay in hospital, delays time critical interventions, and is associated with a higher risk of adverse events.1

Hospital emergency departments across the United Kingdom have faced extreme service pressure …
835 P21CIP1 siRNA enhanced TGF-B-mediated apoptosis in human HCC cells
Authors: T KOGISO, H NAGAHARA, K SHIRATORI
Journal: Hepatology (2003)

Temporally and spatially dynamic Wnt and BMP signals are essential to pattern foregut endoderm progenitors that give rise to the liver, pancreas and lungs, but how these two signaling pathways are coordinated in the extracellular space is unknown. Here we identify the transmembrane heparan sulphate proteoglycan Syndecan-4 (Sdc4), as a key regulator of both non-canonical Wnt and BMP signaling in the Xenopus foregut. Foregut-specific Sdc4 depletion results in a disrupted Fibronectin (Fn1) matrix, reduced cell adhesion, and failure to maintain foregut gene expression ultimately leading to foregut organ hypoplasia. Sdc4 is required to maintain robust Wnt/JNK and BMP/Smad1 signaling in the hhex+ foregut progenitors. Pathway analysis suggests that Sdc4 functionally interacts with Fzd7 to promote Wnt/JNK signaling, which maintains foregut identity and cell adhesion. In addition, the Sdc4 ectodomain is required to support Fn1 matrix assembly, which is essential for the robust BMP signaling that promotes foregut gene expression. This work sheds lights on how the extracellular matrix can coordinate different signaling pathways during organogenesis.
Eczematous drug eruption after infliximab
Authors: M. DUMONT-BERSET, E. LAFFITTE, C. GERBER, J. DUDLER, R.G. PANIZZON
Journal: British Journal of Dermatology (2004)

Sir, Infliximab (Remicade®, Schering‐Plough), a humanized antitumour necrosis factor (TNF)‐α monoclonal antibody, has been associated with several cutaneous side‐effects.1–4 We report a patient with an eczematous eruption that appeared after the administration of infliximab. A 36‐year‐old man presented with a diffuse pruritic rash of 1 week's duration. He had been receiving treatment for 3 months with oral leflunomide 20 mg daily and intravenous infliximab 3 mg kg−1 at weeks 0, 2 and 6 for a palmoplantar pustular psoriasis with severe arthritis. Four days after the third infusion of infliximab he developed a pruriginous maculopapulovesicular erythematosquamous eruption of the limbs and trunk (Fig. 1a). There was no history of allergy or eczema. Abnormal laboratory results included elevated erythrocyte sedimentation rate at 35 mm in the first hour (normal < 10), white blood cell count of 15·1 × 109 L−1 with 71% neutrophils and 1% eosinophils, and C‐reactive protein at 49 mg L−1 (normal < 10). Human immunodeficiency virus, syphilis and Chlamydia serology were negative and there was no evidence for any viral disease. Skin biopsy showed spongiform dermatitis with oedema in the epidermis between keratinocytes and the upper dermis, associated with keratinocyte necrosis, and a lymphocytic infiltrate in the upper dermis (Fig. 1b). The skin condition improved within 2 weeks after stopping the two drugs and the use of topical steroids. One month later, patch tests to leflunomide and infliximab were negative. As infliximab had been proving beneficial for the arthritic condition in this patient, rechallenge with a perfusion of 50 mg of infliximab was attempted. Two days later, the eczematous rash reappeared with an identical histological pattern. Thereafter, infliximab was switched to subcutaneous etanercept (Enbrel®, Wyeth), another TNF‐α inhibitor, without recurrence of the rash.
Plaque Rupture vs Erosion
Authors: Rebecca Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants
Authors: Scott H. Sicherer, Robert A. Wood, Donald Stablein, Robert Lindblad, A. Wesley Burks, Andrew H. Liu, Stacie M. Jones, David M. Fleischer, Donald Y.M. Leung, Hugh A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2010)
Effects of intraaortic balloon pumping on septal arterial blood flow velocity waveform during severe left main coronary artery stenosis
Authors: Akihiro Kimura, Eiji Toyota, Lu Songfang, Masami Goto, Toyotaka Yada, Yoko Chiba, Jun Ebata, Hiroyuki Tachibana, Yasuo Ogasawa, Katsuhiko Tsujioka, Fumihiko Kajiya
Journal: Journal of the American College of Cardiology (1996)
Controlling the Electrocution Hazard in the Hospital
Authors: Sidney R. Arbeit
Journal: JAMA (1972)

The hospitalized patient is in jeopardy from the electrical devices that surround or are attached to him. He is at a special risk because he is frequently grounded by monitoring devices and his protective skin barrier breached. Poorly designed electrical devices and inadequate or improper grounding of the hospital electrical system or of the equipment add to his danger. The adoption of the following steps will reduce this hazard: (1) Never ground the patient; ground everything else. (2) The building wiring and electrical supply, especially its grounding system should be brought up to modern standards. (3) All new electrical equipment should be evaluated for safety and tested before use. (4) An ongoing electrical preventive maintenance program should be established. Isolation power supplies ("safe power centers") have been proposed to reduce or eliminate these hazards but are not recommended.
1148 EFFECT OF THE IL28B SINGLE NUCLEOTIDE POLYMORPHISM (SNP) ON THE FIRST PHASE HEPATITIS C VIRUS KINETICS IN PATIENTS TREATED WITH PEG-INTERFERON AND RIBAVIRIN (PR)
Authors: E. Durante-Mangoni, D. Pinto, C. Battimelli, V. Farinaro, C. Savinelli, A. Senese, V. Iorio, C. Graziano, D. Iossa, R. Molaro, G. Sodano, R. Utili
Journal: Journal of Hepatology (2013)
Sternal Fractures in Motor Vehicle Accident Victims Restrained by Lap–Shoulder Safety Belts
Authors: MARC COEL, GARY SATO
Journal: Clinical Nuclear Medicine (2000)

Lap–shoulder safety belts reduce the risk of fatal injury to front-seat automobile occupants by 45% and the risk of moderate to critical injuries by 50%. Safety belts, however, cause abrasions, chest contusions, neck strains, and fractures to the ribs, sternum, and clavicle. Sternal fractures secondary to automobile accidents, despite safety belt use and without contact between the chest and a fixed part of the automobile, is termed the “seat belt syndrome.” Two cases of the seat belt syndrome are described in which bone scintigraphy appears to distinguish which victim was the driver or passenger at the time of their respective automobile accidents. FIGURE 1Fig. 1: A 70-year-old woman was a front-seat passenger and wore a lap–shoulder safety belt at the time of an automobile accident. She reported chest pain, but the results of chest radiographs at the time were negative. As a result, Tc-99m HDP bone scintigraphy with vascular flow was performed. The blood-pool phase showed increased activity at both sides of the ribs and the sternum. The delayed bone phase with multiple planar projections revealed fractures involving the costochondral junctions of the right fourth and fifth rib, increased activity at the distal aspect of the sternum, and increased activity at the left side of the fourth, fifth, sixth, seventh, eighth, ninth, and tenth ribs, consistent with recent fracture. Of particular interest is the orientation of the fracture, which angles diagonally across the body of the sternum from the right superiorly and down toward the left inferiorly. The fracture orientation is consistent with an injury to the passenger of an automobile wearing a lap–shoulder seat belt (1–3).FIGURE 2Fig. 2: A 42-year-old man was involved in a motor vehicle accident. He was driving the automobile at the time of the accident and was wearing a lap–shoulder safety belt. He reported sternal pain, but the results of chest radiographs at the time were negative. He underwent Tc-99m HDP bone scintigraphy with vascular flow, which revealed an oblique fracture of the body of the sternum consistent with a seat belt injury. Again, the bone scan is noteworthy for the orientation of the fracture, which angles obliquely across the sternal body from the left superiorly and down toward the right inferiorly. The orientation of the fracture is consistent with an injury to the driver of an automobile wearing a lap–shoulder seat belt (4, 5).
Higher “normal” glycated hemoglobin levels were associated with increased risk for diabetes, CVD, stroke, and mortality in adults
Authors: Steven A. Smith
Journal: Annals of Internal Medicine (2010)

ACP Journal Club20 July 2010Higher "normal" glycated hemoglobin levels were associated with increased risk for diabetes, CVD, stroke, and mortality in adultsSteven A. Smith, MDSteven A. Smith, MDMayo Clinic Rochester, Rochester, Minnesota, USA (S.A.S.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-2-201007200-02013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSelvin E, Steffes MW, Zhu H, et al. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med. 2010;362:800-11. https://pubmed.ncbi.nlm.nih.gov/20200384Clinical Impact RatingsGIM/FP/GP: Cardiology: Endocrinology: References1 Selvin E, Zhu H, Brancati FL. Elevated A1c in adults without a history of diabetes in the US Diabetes Care. 2009;32:828-33. [PMID: 19196895] Google Scholar2 Fonseca V, Inzucchi SE, Ferrannini E. Redefining the diagnosis of diabetes using glycated hemoglobin [Editorial]. Diabetes Care. 2009;32:1344-5. [PMID: 19564477] Google Scholar3 Bloomgarden ZT. Cardiovascular disease, neuropathy, and retinopathy. Diabetes Care. 2009;32:e64-8. [PMID: 19460904] Google Scholar4 Little RR. Glycated hemoglobin standardization—National Glycohemoglobin Standardization Program (NGSP) perspective. Clin Chem Lab Med. 2003;41:1191-8. [PMID: 14598869] Google Scholar5 Holmes EW, Erşahin C, Augustine GJ, et al. Analytic bias among certified methods for the measurement of hemoglobin A1c: a cause for concern? Am J Clin Pathol. 2008;129:540-7. [PMID: 18343780] Google Scholar Author, Article, and Disclosure InformationAffiliations: Mayo Clinic Rochester, Rochester, Minnesota, USA (S.A.S.)This article was published at Annals.org on 6 July 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Structure of Relationships between the Human Exposome and Cardiometabolic Health: The Million Veteran ProgramGlycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without DiabetesCoronary Heart Disease and Dietary Carbohydrate, Glycemic Index, and Glycemic Load: Dose-Response Meta-analyses of Prospective Cohort StudiesStroke due to Systemic Diseases"Tight Control" in Geriatrics: The Emperor Wears a Thong 20 July 2010Volume 153, Issue 2Page: JC1-13KeywordsCohort studiesCoronary heart diseaseGlucoseHbA1cHemoglobinHypertensionIschemic stroke ePublished: 20 July 2010 Issue Published: 20 July 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Induction of Protective CTL Immunity against Peptide Transporter TAP-Deficient Tumors through Dendritic Cell Vaccination
Authors: Benedict Chambers, Per Grufman, Vanoohi Fredriksson, Kenth Andersson, Marjet Roseboom, Sandra Laban, Marcel Camps, Elisabeth Z. Wolpert, Emmanuel J.H.J. Wiertz, Rienk Offringa, Hans-Gustaf Ljunggren, Thorbald van Hall
Journal: Cancer Research (2007)

Abstract A large proportion of human cancers show deficiencies in the MHC class I antigen-processing machinery. Such defects render tumors resistant to immune eradication by tumoricidal CTLs. We recently identified a unique population of CTL that selectively targets tumor immune-escape variants through recognition of MHC-presented peptides, termed TEIPP (T cell epitopes associated with impaired peptide processing), expressed on cells lacking functional TAP-peptide transporters. Previously, we showed that vaccination with TEIPP peptides mediates protection against TAP-deficient tumors. Here, we further explored the concept of TEIPP-targeted therapy using a dendritic cell (DC)–based cellular vaccine. Impairment of TAP function in DC induced the presentation of endogenous TEIPP antigens by MHC class I molecules, and immunization with these DCs protected mice against the outgrowth of TAP-deficient lymphomas and fibrosarcomas. Immune analysis of vaccinated mice revealed strong TEIPP-specific CTL responses, and a crucial role for CD8+ cells in tumor resistance. Finally, we show that TEIPP antigens could be successfully induced in wild-type DC by introducing the viral TAP inhibitor UL49.5. Our results imply that immune intervention strategies with TAP-inhibited DC could be developed for the treatment of antigen processing–deficient cancers in humans. [Cancer Res 2007;67(18):8450–5]
Health assembly adopts new regulations for tackling emergencies
Authors: Paul Ress
Journal: BMJ (2005)

New regulations for managing public health emergencies of international concern, such as outbreaks of avian flu, severe acute respiratory syndrome (SARS), polio, and Marburg haemorrhagic fever, were unanimously agreed this week by the World Health Assembly.

These new rules replace the current regulations, which were adopted in 1969 and which are out of date. The old regulations were designed to combat six infectious diseases: cholera, smallpox, yellow fever, typhus, plague, and relapsing fever. The new regulations cover a much larger number of dangerous diseases including …
Trials of New Methods
Authors: DAVID H. SPODICK
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 March 1982Trials of New MethodsDAVID H. SPODICK, M.D., D.SC.DAVID H. SPODICK, M.D., D.SC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-377_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The editorial by Goldberg and associates in the January issue (1) is a masterly condensation of the state of the art of intracoronary thrombolysis. As is almost de rigeuer, there is a final call for "carefully designed multicenter randomized trials." I am certain that these authors are quite sincere. One wonders, however, as too often in the past, whether the genie is out of the bottle. Catheterization laboratories are picking up this approach everywhere and on pseudoethical grounds they will once again "not be able to deny" their patients a treatment that they "know" works.Unfortunately for...Reference1. GOLDBERGMAROKOENGEL SPT. Intracoronary thrombolysis for acute myocardial infarction. Ann Intern Med. 1982;96:115-7. Editorial. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Massachusetts Medical School St. Vincent Hospital Worcester, MA 01604 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1982Volume 96, Issue 3Page: 377-377KeywordsCatheterizationPatientsRandomized trials Issue Published: 1 March 1982 PDF DownloadLoading ...
Is the statistical assessment of papers submitted to the "British Medical Journal" effective?
Authors: M J Gardner, D G Altman, D R Jones, D Machin
Journal: BMJ (1983)

A study was performed to judge the effectiveness of the statistical assessment scheme for papers submitted to the "British Medical Journal." Statistical criticism of the content of 200 submitted papers which had already been seen by a subject referee led directly or indirectly to 73 (37%) being rejected for publication. In most cases (53 out of 73) serious problems requiring more than minor revision were identified. A comparison of reports on subsequently unpublished and published papers showed that adverse statistical assessments--suggesting major problems--were more common in the papers that were not accepted for publication. Moderate, or less, revision was recommended for 63% of published papers but 39% of the remainder. A checklist of relevant questions was used in making a detailed comparison of 12 published papers, six of which had been statistically assessed and six of which had not. This comparison yielded little evidence that the papers that had been assessed were statistically more acceptable than those that had not been assessed but re-emphasised the subjectivity of refereeing and assessment.