tbuckley/cabot-search huggingface dataset:
SOME CLINICAL EXPERIENCES WITH EUCALYPTOL.Read by Title in the Section of Medicine and Physiology at the Forty-Second Annual Meeting of the American Medical Association, held at Washington, D. C., May 5, 1891.
Authors: I. N. BRAINERD
Journal: JAMA (1891)

During the last ten years I have often prescribed eucalyptol in bronchial and pulmonary troubles. From this experience I have learned to put a high therapeutic value upon it in some respiratory affections, viz.: chronic bronchitis, persistent cough, chronic interstitial pneumonia, and to a less degree in tuberculosis. The following list of cases taken from my later experience, furnishes a reasonable amount of proof of its utility: <i>Case 1.</i>—Miss Bellard, aged 19. This lady called upon me in August, 1888. She complained of malaise, and some pain in the left lung. She had only a moderate cough and a limited expectoration. The temperature was 99. Auscultation revealed a harsh and catchy respiration in the upper lobe of the left lung. A trifling dulness on percussion could be discovered in this region. I gave the girl eucalyptol, and had her visit my office every fortnight for half a year. She so
RELATIONSHIP OF ORIFICE GEOMETRY OF ANOMALOUS CORONARY ARTERIES ARISING FROM OPPOSING CORONARY SINUSES (ACAOS) TO FUNCTIONAL MYOCARDIAL ISCHEMIA AND CLINICAL OUTCOMES: EVALUATION BY 64-DETECTOR ROW CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY
Authors: Kelly Axsom, Troy LaBounty, Jin-Ho Choi, James K. Min, Fay Y. Lin
Journal: Journal of the American College of Cardiology (2010)
Plasminogen Activator <i>uPA</i> Is a Direct Transcriptional Target of the JAG1-Notch Receptor Signaling Pathway in Breast Cancer
Authors: Mamiko Shimizu, Brenda Cohen, Pavel Goldvasser, Hal Berman, Carl Virtanen, Michael Reedijk
Journal: Cancer Research (2011)

Abstract Aberrant activation of the Notch receptor signaling pathway and overexpression of the Notch ligand JAG1 are associated with poor outcome in breast cancer. The plasminogen activator system, which includes urokinase-type plasminogen activator (uPA), has been validated as a marker of recurrence, high metastasis risk and death in breast malignancy. By using microarray profiling of breast cancer cell lines that had undergone siRNA-mediated abrogation of Notch signaling we uncovered a link between activated Notch signaling and uPA expression. An association between elevated expression of the Notch ligand JAG1, uPA, and the basal-like breast cancer subtype was confirmed in breast cancer cell lines. The association between JAG1 and uPA expression persisted in a survey of primary carcinomas of the breast. We found that Notch knockdown reduced transcription of uPA and phenocopied uPA knockdown in breast cancer cells. Through mutational analysis we identified a CBF-1 binding site in the uPA promoter that is required for direct transcriptional regulation by Notch. These data suggest that JAG1-induced Notch activation results in breast cancer progression through upregulation of the plasminogen activator system, directly linking these 2 important pathways of poor prognosis. Cancer Res; 71(1); 277–86. ©2010 AACR.
PTH-115 Outcome of Ulcerative Colitis Patients that have Failed Conventional Thiopurine Therapy; Allopurinol Co-Therapy and Beyond
Authors: T Hollingworth, H Johnson, R Basuroy, S Mclaughlin, S Weaver
Journal: Gut (2013)

<h3>Introduction</h3> Treatments available for Ulcerative Colitis (UC) are limited in those who fail thiopurines. British society of gastroenterology guidelines suggest the use of methotrexate (MTX) or colectomy in this group as biologics are not funded in UC in England or Wales. Clinical treatments used in our unit include low dose thiopurine and allopurinol co-therapy (LDTA) and topical arsenic. We report our experience of patients who have failed standard dose thiopurines and their subsequent treatment and clinical outcomes. <h3>Methods</h3> UC patients who failed conventional thiopurine therapy were identified from our prospective inflammatory bowel disease database. Reasons for failure, disease extent, length of follow-up and subsequent treatment pathway were identified. Data from patients with &lt; 3 months follow-up was disregarded. <h3>Results</h3> 20 patients were identified, 12 initially started LDTA and 10 started MTX (2 patients received LDTA and then MTX). Mean age was 47 (range: 22–60yrs), 15 were male. 8 had pancolitis, 9 left sided UC and 4 proctitis. Reasons for failure of conventional dose thiopurine were; Hepatitis (n = 5), therapeutic 6-thioguanine levels without clinical remission (n = 11), intolerable side effects (n = 3), dyserythropoeisis (n = 1) and gout (n = 1). Of those patients commenced on LDTA; 10 (83%) entered clinical remission. 2 (17%) failed due to lack of clinical response and commenced MTX. 10 remain in a sustained clinical remission at a mean length of follow up of 16.2 months (range: 4–23). Of the 10 patients commenced on MTX; 7 (70%) failed due to lack of clinical response and 1 (10%) due to side-effects (Pneumonitis). Of those patients that failed; 4 (40%) underwent colectomy, 2 (20%) received arsenic suppositories and entered a sustained clinical remission. 2 (20%) were reclassified to Crohn’s disease, were treated with biologic therapy and entered a sustained clinical remission. Mean length of follow up in this group was 17.6 months (range: 2–30). <h3>Conclusion</h3> Thiopurines remain the mainstay of treatment for patients with UC. A significant number of patients fail this conventional treatment and represent a clinical challenge. Novel treatments such as LDTA can be effective in a significant proportion of this group. Data for the efficacy of MTX remains less effective and topical arsenic is useful and can be helpful. <h3>Disclosure of Interest</h3> T. Hollingworth: None Declared, H. JOHNSON Conflict with: SPONSORSHIP FROM FALK, ABBOTT &amp; WARNER CHILCOTT TO ATTEND MEETINGS, R. BASUROY: None Declared, S. MCLAUGHLIN Conflict with: SPONSORSHIP FROM FALK TO ATTEND MEETINGS, S. WEAVER Consultant for: MSD ADVISORY BOARD, Conflict with: SPONSORSHIP FROM FALK, ABBOT, MSD &amp; FERRING TO ATTEND MEETINGS
Trust hospitals and vascular services
Authors: J H N Wolfe, P L Harris, C V Ruckley
Journal: BMJ (1994)

EDITOR, - We write to express concern over the detrimental effect that trust hospitals are having on strategic planning for vascular services. Many recent consultant appointments have been of singlehanded vascular surgeons in district hospitals as they adopt trust status. The proportion of singlehanded surgeons fell from 43% to 7% between 1988 and 1992 but will inevitably rise as a result of these appointments.

This problem has recently been highlighted in South West Thames region, where retiring single-handed vascular surgeons have been automatically replaced at separate but adjacent hospitals and the opportunity for rationalisation and improvement in services and …
Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor–1
Authors: Edward J. Weinman, Rajat S. Biswas, Quihong Peng, Lily Shen, Christina L. Turner, Xiaofei E, Deborah Steplock, Shirish Shenolikar, Rochelle Cunningham
Journal: Journal of Clinical Investigation (2007)

Parathyroid hormone (PTH), via activation of PKC and/or protein kinase A, inhibits renal proximal tubular phosphate reabsorption by facilitating the internalization of the major sodium-dependent phosphate transporter, Npt2a. Herein, we explore the hypothesis that the effect of PTH is mediated by phosphorylation of serine 77 (S77) of the first PDZ domain of the Npt2a-binding protein sodium-hydrogen exchanger regulatory factor-1 (NHERF-1). Using recombinant polypeptides representing PDZ I, S77 of NHERF-1 is phosphorylated by PKC but not PKA. When expressed in primate kidney epithelial cells (BSC-1 cells), however, activation of either protein kinase phosphorylates S77, suggesting that the phosphorylation of PDZ I by PKC and PKA proceeds by different biochemical pathways. PTH and other activators of PKC and PKA dissociate NHERF-1/Npt2a complexes, as assayed using quantitative coimmunoprecipitation, confocal microscopy, and sucrose density gradient ultracentrifugation in mice. Murine NHERF-1-/- renal proximal tubule cells infected with adenovirus-GFP-NHERF-1 containing an S77A mutation showed significantly increased phosphate transport compared with a phosphomimetic S77D mutation and were resistant to the inhibitory effect of PTH compared with cells infected with wild-type NHERF-1. These results indicate that PTH-mediated inhibition of renal phosphate transport involves phosphorylation of S77 of the NHERF-1 PDZ I domain and the dissociation of NHERF-1/Npt2a complexes.
Sézary Syndrome— A Malignant Reticulemic Erythroderma
Authors: Howard F. Taswell
Journal: JAMA (1961)

Seven cases are presented of an exfoliative erythroderma with intense pruritus, edema, pigmentation, superficial lymphadenopathy, hepatomegaly, leonine facies, alopecia, dystrophic nails, and hyperkeratosis of the palms and soles. A cutaneous infiltrate of atypical mononuclear cells is present in this condition and is associated with an increased leukocyte count and with an abundance of these atypical cells in the peripheral blood. The cell is characterized by a large, convoluted nucleus with a narrow rim of cytoplasm frequently containing numerous vacuoles in a necklace-like arrangement around the nucleus. Within these vacuoles is an intensively PAS-positive, diastase-resistant neutral mucopolysaccharide. Patients with this disease remain in good general condition for a long time. Treatment with superficial irradiation, steroids, and cytotoxic agents yields only temporary relief. Death occurs approximately 5 years after the first symptoms have been noted.
THE VIRULENCE OF AN EPIDEMIC STRAIN OF BACILLUS PESTIS CAVIÆ
Authors: Leslie T. Webster
Journal: The Journal of Experimental Medicine (1923)

Ever since Pasteur's demonstration of the modifying effect of animal passage on the virulence of bacteria, this device has been regarded as of great importance in intensifying infective capacity. It is not often, however, that extensive parallel tests have been made of the power of a microorganism to produce infection in a species of animal which is its natural habitat and under conditions in which the normal as well as artificial portal of entry is employed, and the potency of the microorganism passed directly from host to host is closely contrasted with that of one merely artificially cultivated outside the body. The experiments described in this paper were arranged to fulfill these conditions. The results show that with the particular strain of Bacillus festis caviæ used, successive animal passages do not modify infective capacity, or virulence. This finding is in harmony with the observations previously made from which it was concluded that the epidemic curve of mouse typhoid infection is explicable solely on the basis of bacillary distribution and host susceptibility.
Splenosis presenting as occult gastrointestinal bleeding
Authors: William M. Sikov, Fred J. Schiffman, Michael Weaver, Jacob Dyckman, Richard Shulman, Philip Torgan
Journal: American Journal of Hematology (2000)

A 48-year-old man presented with recurrent gastrointestinal bleeding and anemia. Routine endoscopic evaluation was nondiagnostic. Angiography demonstrated multiple apparent arteriovenous malformations. Exploratory laparotomy revealed numerous splenic implants along the small and large bowels, some of which had apparently eroded through the bowel mucosa and bled. Excision of these penetrating lesions prevented further bleeding. An incidentally noted renal cell cancer was also resected. The patient's splenosis was the result of childhood trauma that caused splenic rupture and precipitated splenectomy. Splenosis develops frequently following traumatic splenic rupture. Experimental evidence suggests that the presence of an intact spleen suppresses the growth and development of splenic implants. Following splenectomy, splenules may replace some of the "housekeeping" and immunologic functions of the spleen, but even patients with documented splenosis should be considered functionally hyposplenic. While in most cases splenules cause no symptoms, splenosis must be considered in the differential diagnosis of previously splenectomized patients who present with unexplained masses or occult bleeding. Am. J. Hematol. 65:56–61, 2000. © 2000 Wiley-Liss, Inc.
TCT-592 Incidence, imaging and clinical outcomes of acute scaffold disruption and late structural discontinuity after implantation of the Absorb everolimus-eluting fully bioresorbable vascular scaffold: Optical coherence tomography assessment in the ABSORB Cohort B trial
Authors: Yoshinobu Onuma, Patrick W. Serruys, Takashi Muramatsu, Shimpei Nakatani, Robert J Van Geuns, Bernard De Bruyne, Dariusz Dudek, Leif Thuesen, Pieter C. Smits, Bernard Chevalier, Jacques Koolen, Stephan Windecker, Robert J. Whitbourn, Ian T. Meredith, Hector M. Garcia-Garcia, Susan Veldhof, Richard Rapoza, John A. Ormiston
Journal: Journal of the American College of Cardiology (2013)
Hemodynamic Response of the Pulmonary Circulation to Bronchopulmonary Lavage in Man
Authors: Robert M. Rogers, Jan P. Szidon, James Shelburne, John L. Neigh, John F. Shuman, Kermit R. Tantum
Journal: New England Journal of Medicine (1972)

During 16 bronchopulmonary lavages on nine patients, only mild hypoxemia developed. Since blood perfusing the liquid-filled lung is not exposed to alveolar gas, this suggests decreased perfusion of the lavaged lung. During four lavages, the degree of perfusion of the lavaged lung was shown to increase with the difference between the pressure in the pulmonary artery and the hydrostatic pressure of fluid filling the lavaged lung. To increase the safety of bronchopulmonary lavage, one should use high concentrations of inspired oxygen, maintain airway pressure of the lavaged lung above or as close as possible to pulmonary-artery pressure, and closely monitor arterial-blood gases.
A1C but Not Serum Glycated Albumin Is Elevated Because of Iron Deficiency in Late Pregnancy in Diabetic Women
Authors: Kunihiko Hashimoto, Tomoaki Osugi, Sanai Noguchi, Yasuhiko Morimoto, Kenshi Wasada, Shiro Imai, Masako Waguri, Rieko Toyoda, Tomio Fujita, Soji Kasayama, Masafumi Koga
Journal: Diabetes Care (2009)

OBJECTIVE We have already reported that A1C is elevated because of iron deficiency in late pregnancy among nondiabetic pregnant women. This report examined whether the same phenomenon is observed in pregnant women with diabetes. RESEARCH DESIGN AND METHODS This longitudinal study was conducted in 17 pregnant women with diabetes (20-35 weeks of pregnancy). A1C, serum glycated albumin, erythrocyte indexes, and iron metabolism indexes were measured. RESULTS A1C levels were significantly increased in late pregnancy, whereas serum glycated albumin showed no significant changes. Glycated albumin/A1C ratio, mean corpuscular hemoglobin, serum transferrin saturation, and serum ferritin were significantly decreased in late pregnancy. Serum transferrin saturation showed a significant positive correlation with glycated albumin/A1C ratio. CONCLUSIONS A1C levels, but not serum glycated albumin levels, are elevated in late pregnancy because of iron deficiency in diabetic women. Serum glycated albumin may offer an adequate marker for glycemic control during pregnancy.
What Is Psychiatry? A New Model of Service and Education
Authors: ALEXANDER Z. GUIORA, SAUL I. HARRISON
Journal: American Journal of Psychiatry (1973)

The authors review the history of mental health models as well as related systems of professional education and service delivery. The current situation is criticized as being too concerned with professional privilege and hierarchies while seeming to ignore both gaps in and duplication of services. The authors therefore suggest the need for more organizational paradigms for the mental health field; these are to be derived rationally from the community's needs and the expanding knowledge pool. To the authors this suggests a system of hierarchical education based on career steps that could be entered at various levels of competence and certification.
The precore sequence of hepatitis B virus is required for nuclear localization of the core protein
Authors: N Aiba, M J McGarvey, J Waters, S J Hadziyannis, H C Thomas, P Karayiannis
Journal: Hepatology (1997)

The cellular localization of the precore/core and core proteins was studied by immunofluorescence following transfection of 143 thymidine kinase-negative (TK ) and Hep-G2 cells with expression constructs containing wild-type (hepatitis B e antigen [HBeAg]-positive) and precore mutant (HBeAg-negative) sequences. Precore/core constructs with the wild-type phenotype result in strong nuclear staining, while, in contrast, constructs expressing core antigen alone have strong cytoplasmic staining. These differences in the pattern of immunofluorescence staining may be caused by expression of the precore/core protein, some of which may be translocated into the nucleus, following removal of the signal peptide. In vitro translation experiments showed that the main protein products obtained in the presence of microsomal membranes were the precore/core protein and a truncated product representing the same protein without its signal peptide. Core protein expression from the precore mutant constructs was very much reduced, indicating that translational re-initiation was not very efficient. The significance of the precore/core protein being present in the nucleus is not clear, but suggests that it may be important in the replicative cycle of the virus. Finally, HBeAg produced by some of the constructs could not be detected because amino acid substitutions affected antibody-binding epitopes.
Tumoral acidic pH-responsive MPEG-poly(β-amino ester) polymeric micelles for cancer targeting therapy
Authors: Kyung Hyun Min, Jong-Ho Kim, Sang Mun Bae, Hyeri Shin, Min Sang Kim, Sangjin Park, Hyejung Lee, Rang-Woon Park, In-San Kim, Kwangmeyung Kim, Ick Chan Kwon, Seo Young Jeong, Doo Sung Lee
Journal: Journal of Controlled Release (2010)
Women and scuba diving.
Authors: J E Cresswell, M St Leger-Dowse
Journal: BMJ (1991)

partnership between doctors and hospital managers, but if they are to succeed and be relevant doctors must play a major part in their design.Unfortunately, there is still much confusion and lack of knowledge among doctors even in hospitals where computerisation is advanced (box).My message to doctors is that if you want to influence these systems spend time working out your clinical information needs and ensure that the system is relevant to them.1 Lytinen K. Stakeholders, IS failures and soft systems methodology.Jfournal of
Lymphatic abnormalities demonstrated by lymphoscintigraphy after lower limb cellulitis
Authors: J.K. Soo, T.A. Bicanic, S. Heenan, P.S. Mortimer
Journal: British Journal of Dermatology (2008)

Journal Article Lymphatic abnormalities demonstrated by lymphoscintigraphy after lower limb cellulitis Get access J.K. Soo, J.K. Soo Department of Dermatology Correspondence: Julia Soo. E‐mail: jsoo@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar T.A. Bicanic, T.A. Bicanic Clinical Infection Unit Search for other works by this author on: Oxford Academic Google Scholar S. Heenan, S. Heenan Department of Radiology, St Georges's Hospital, Blackshaw Road, London SW17 0QT, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.S. Mortimer P.S. Mortimer Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 6, 1 June 2008, Pages 1350–1353, https://doi.org/10.1111/j.1365-2133.2007.08423.x Published: 01 June 2008
POEMS syndrome associated with multiple hemangiomas of the small bowel and colon
Authors: T. Meister, H. Heinzow, F. Lenze, H. Ullerich, W. Domschke, D. Domagk
Journal: Endoscopy (2008)

POEMS is an acronym for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. POEMS syndrome is a rare disorder, with only a limited number of cases reported in the literature. The first descriptions of POEMS syndrome were published by Crow in 1956 [1] and by Fukase in 1968 [2]. It is therefore also known as Crow–Fukase syndrome. The symptom complex of POEMS syndrome includes skin changes such as hyperpigmentation, skin thickening, sclerodermoid changes, hypertrichosis, and hemangiomas [3]. Glomeruloid hemangiomas of the skin are thought to be specific to POEMS syndrome and have been shown to affect one-third of patients [4].
Biochemistry: A Case-Oriented Approach
Authors: John G. Coniglio
Journal: JAMA (1984)

The fourth edition of this biochemistry book will be welcomed by those who are acquainted with the preceding three editions. Since the introduction of the first edition in 1974, this text has provided students of medical biochemistry with a valuable resource for relating basic biochemical concepts to practical problems in clinical medicine. The current edition preserves this usefulness and adds both to the cases presented and to the basic biochemical information related to these cases.  This text is the product of the teaching program in biochemistry at the University of Iowa, Iowa City. In the third and fourth editions enough biochemical information has been added that the authors believe the biochemical content is adequate for a one-semester course in biochemistry. A substantial amount of this information is included in the discussions of the case problems. Although some schools may find this book adequate as the sole text for a beginning
Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation
Authors: Hamza Celik, Cates Mallaney, Alok Kothari, Elizabeth L. Ostrander, Elizabeth Eultgen, Andrew Martens, Christopher A. Miller, Jasreet Hundal, Jeffery M. Klco, Grant A. Challen
Journal: Blood (2014)