Esophageal Ulceration Induced by Zidovudine
Authors: Paul Edwards
Journal: Annals of Internal Medicine (1990)

Brief Reports1 January 1990Esophageal Ulceration Induced by ZidovudinePaul Edwards, MB, Jennifer Turner, MB, Julian Gold, MB, David A. Cooper, MDPaul Edwards, MBSearch for more papers by this author, Jennifer Turner, MBSearch for more papers by this author, Julian Gold, MBSearch for more papers by this author, David A. Cooper, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-1-65 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEsophageal injury induced by oral medication is well documented by over 300 case reports (1-3). In two major studies (1, 2), age, posture, volume of fluid chaser, and dissolution pH of the medication were identified as the major factors influencing esophageal injury. Zidovudine, an antiviral agent capable of inhibiting in-vitro replication of the human immunodeficiency virus (HIV), is the only treatment of proven efficacy for persons with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. Because of zidovudine's pharmacokinetic profile, it is recommended that it be taken every 4 hours around the clock to obtain maximum virustatic effect.We report...References1. KikendallFriedmanOyewoleFleischerJohnson JAMDL. Pill-induced oesophageal injury. Case reports and review of the medical literature. Dig Dis Sci. 1983;28:174-82. CrossrefMedlineGoogle Scholar2. BonavinaDeMeesterMcChesneySchwizerAlbertucciBailey LTLWMR. Drug-induced oesophageal strictures. Ann Surg. 1987;206:173-83. CrossrefMedlineGoogle Scholar3. EvansRoberts KG. Where do all the tablets go? Lancet. 1976;2:1237-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From St. Vincent's Hospital, Albion Street (AIDS) Centre, Sydney Hospital, University of New South Wales, New South Wales, Australia. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedication‐Induced Esophageal InjuryA HAART-Breaking Review of Alternative Antiretroviral Administration: Practical Considerations with Crushing and Enteral Tube ScenariosDrug-Induced Esophageal InjuryPill-Induced Esophageal InjuryEsophagitisDysphagia in a HIV Patient: Concern for the Etiology?Drug-Induced Esophageal Injuries and DysphagiaDiagnosis and Management of Infectious Esophagitis Associated with Human Immunodeficiency Virus InfectionEsophageal Disease in Patients with AIDS: Diagnosis and TreatmentHerpes esophagitis: a comprehensive reviewORAL AND ESOPHAGEAL DISORDERSGastrointestinal Manifestations in Pediatric AidsGASTROINTESTINAL MANIFESTATIONSGASTROINTESTINAL AND NUTRITIONAL PROBLEMS IN CHILDREN WITH IMMUNODEFICIENCY AND AIDSZalcitabine-associated pharyngeal ulcersNoninfectious Manifestations of Human Immunodeficiency Virus InfectionIdiopathic esophageal ulceration in the acquired immunodeficiency syndrome: Radiologic reappraisal in 10 patientsPain in human immunodeficiency virus disease: a reviewDrug-Induced EsophagitisSerious Gastrointestinal Disorders Associated with Human Immunodeficiency Virus InfectionAids: Part IIZidovudine: Five Years LaterGavin X. McLeod, MD, Scott M. Hammer, MDA pilot study of oral corticosteroid therapy for idiopathic esophageal ulcerations associated with human immunodeficiency virus infectionAdverse EffectsEsophageal Ulceration Related to Zalcitabine (ddC)Amy S. Indorf, MD, P. Samuel Pegram, MDEsophageal disease in the acquired immunodeficiency syndrome: Etiology, diagnosis, and managementZidovudine-induced hepatitisAntiretroviral therapy: reverse transcriptase inhibitionGastrointestinal ManifestationsBacterial and Fungal InfectionsMiscellaneous antibacterial and antiviral drugsGastrointestinal emergencies in HIV infectionUlcération pharyngée chez un patient atteint de SIDA : efficacité de la corticothérapieThe use of drugs in patients with gastrointestinal manifestations of AIDS 1 January 1990Volume 112, Issue 1Page: 65-66KeywordsAIDSAIDS related complexAnatomical pathologyAntiviralsClinical epidemiologyHIVPharmacokineticsPostural controlResearch grantsUlcers Issue Published: 1 January 1990 PDF downloadLoading ...