tbuckley/cabot-search huggingface dataset:
Changes in serum fibrogenesis markers during interferon therapy for chronic hepatitis type C
Authors: K Ishibashi, T Kashiwagi, A Ito, Y Tanaka, M Nagasawa, T Toyama, S Ozaki, M Naito, M Azuma
Journal: Hepatology (1996)

We serially measured the levels of serum N-terminal peptide of type III procollagen (PIIINP), the 7S domain of type IV collagen (IV-7S), and hyaluronate (HA) before (0 month), at the end (6 months), and 24 weeks after the end of interferon therapy (12 months) in patients with chronic hepatitis type C to estimate the effects of interferon alfa (IFN-alpha) on serum levels of hepatic fibrogenesis markers. One hundred twenty-one patients with chronic hepatitis type C received intramuscular injection of 6 million U of natural IFN-alpha for 24 weeks. Patients were divided into three groups: sustained complete response (CR-S), complete response with rebound (CR-R), and nonresponse (NR). Serum PIIINP, IV-7S, and HA levels were significantly decreased and reached normal levels at 12 months in CR-S; only IV-7S levels were significantly decreased at 12 months in CR-R, whereas these levels remained abnormally high in the NR. These results suggest that IFN-alpha therapy could lower the levels of serum hepatic fibrogenesis markers along with improvements in hepatic inflammation.
Sudden Infant Death Syndrome and Brain Abnormalities—Reply
Authors: David S. Paterson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation
Authors: Ilaria Meloni, Maddalena Muscettola, Martine Raynaud, Ilaria Longo, Mirella Bruttini, Marie-Pierre Moizard, Marie Gomot, Jamel Chelly, Vincent des Portes, Jean-Pierre Fryns, Hans-Hilger Ropers, Barbara Magi, Cristina Bellan, Nila Volpi, Helger G. Yntema, Sarah E. Lewis, Jean E. Schaffer, Alessandra Renieri
Journal: Nature Genetics (2002)
The Diagnosis of Gonococcal Arthritis: Evaluation of the Immunofluorescent Antibody Test.
Authors: Evelyn V. Hess
Journal: Annals of Internal Medicine (1969)

s1 May 1969The Diagnosis of Gonococcal Arthritis: Evaluation of the Immunofluorescent Antibody Test.Evelyn V. Hess, M.D., M. J. Heimbrock, M.S.Evelyn V. Hess, M.D.Search for more papers by this author, M. J. Heimbrock, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1090_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGonococcal arthritis continues to be a common cause of infectious arthritis and may be on the increase. The various modes of presentation often make early diagnosis difficult. The authors first reported the use of an immunofluorescent method in detecting the antibody response in 1965. Clinical observations and immunologic investigations have been extended since that time.Formalin-fixed smears are prepared fromNeisseria gonorrhoeaecultures harvested at 18 hr, and test sera followed by conjugated antigamma globulin are incubated with the organisms. Eighty-five percent of the sera of 30 patients with definite gonococcal arthritis in whom organisms were cultured in joint, cervical,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1090-1090KeywordsAntibody productionArthritisClinical immunologyGlobulinsNeisseria gonorrhoeae Issue Published: 1 May 1969 PDF DownloadLoading ...
Cold Technetium-99m HDP and Hot Gallium-67 Images of Metastatic Adenocarcinoma of Bone
Authors: CHANG-SOO AHN, DONALD E. TOW
Journal: Clinical Nuclear Medicine (1988)

A 58-year-old man had weight loss and painful swelling in his left hip area. Tc-99m HDP three-phase imaging revealed a doughnut-shaped area of increased blood pool in the left sacroiliac joint. The delayed images revealed a round photon-deficient lesion in the same area. The area was strongly hot in the 24-hour Ga-67 images. An x-ray of the pelvis showed no abnormalities. A bone biopsy revealed metastatic adenocarcinoma of unknown primary. Further evaluation, including upper gastrointestinal series, colonoscopy, CT scan, examination of the prostate, thyroid imaging, and intravenous pyelogram failed to detect the origin.
ELI LILLY MEDICAL RESEARCH FELLOWSHIP (SOUTH AFRICA)
Authors: L. Eales
Journal: JAMA (1952)

<h3>To the Editor:—</h3> I should like, through the courtesy of your columns, to draw the attention of medical practitioners registered in South Africa who may at present be in the United States to the fact that applications may be submitted for the 1952 award of the Eli Lilly Medical Research Fellowship. Further details can be obtained from the address below. The closing date for applications is May 8, 1952.
Zonal gene expression in murine liver: Lessons from tumors
Authors: Stephan Hailfinger, Maike Jaworski, Albert Braeuning, Albrecht Buchmann, Michael Schwarz
Journal: Hepatology (2006)

Gene expression in hepatocytes within the liver lobule is differentially regulated along the portal to central axis; however, the mechanisms governing the processes of zonation within the lobule are unknown. A model for zonal heterogeneity in normal liver is proposed, based on observations of differential expression of genes in liver tumors from mice that harbor activating mutations in either Catnb (which codes for beta-catenin) or Ha-ras. According to the model, the regulatory control consists of two opposing signals, one delivered by endothelial cells of the central veins activating a beta-catenin-dependent pathway (retrograde signal), the other by blood-borne molecules activating Ras-dependent downstream cascades (anterograde signal). In conclusion, gradients of opposing signaling molecules along the portocentral axis determine the pattern of enzymes and other proteins expressed in hepatocytes of the periportal and pericentral domains of the liver lobule.
Thyroid-stimulating antibody activity between different immunoglobulin G subclasses.
Authors: A P Weetman, M E Yateman, P A Ealey, C M Black, C B Reimer, R C Williams, B Shine, N J Marshall
Journal: Journal of Clinical Investigation (1990)

To investigate the distribution of thyroid-stimulating antibody (TSAb) activity between IgG subclasses, sera from 11 patients with Graves disease (including the National Institute of Biological Standards and Control (NIBSC) Research Standard, long acting thyroid stimulator-B) were fractionated by chromatography on affinity columns of monoclonal IgG subclass antibodies or protein A to deplete all but a single subclass. The resulting fractions were 98% or more pure for a single subclass. In all 11 patients, TSAb activity appeared to be confined to the IgG1 fraction as determined by cAMP production on addition of the fractions to the FRTL-5 rat thyroid cell line. In all of eight specimens from seven patients so tested, the whole serum activity was recovered in the IgG1 fraction, after adjusting for the recovery of the isotype from the column. TSAb activity in one serum comprised both lambda and kappa light chains but was IgG1 restricted. This IgG subclass restriction was not found when the same fractions were tested for thyroglobulin, microsomal/thyroid peroxidase, or tetanus toxoid antibody activity. Together with previous results showing marked restriction of both light chain usage and isoelectric point of TSAb, these results support the idea that Graves' disease may be the result of an oligo- or possibly monoclonal response at the B cell level.
The Exodus of a Medical School
Authors: Michael Nevins
Journal: Annals of Internal Medicine (1995)

Letters15 December 1995The Exodus of a Medical SchoolMichael Nevins, MDMichael Nevins, MDWestwood, NJ 07675Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-12-199512150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Edzard Ernst's praiseworthy article [1] about the fate of Viennese Jewish physicians in 1938 contains a statement that deserves comment. Dr. Ernst notes that, “Historically, medicine had been the only academic subject that Jews were allowed to take up (during the great plagues of the Middle Ages, doctoring was a risky business).” The implication is that during the plagues, Jewish physicians were considered to be expendable, the medical equivalent of cannon fodder, an attitude that explained their entry into the medical field in disproportionate numbers. I suggest that such a reading of history is unsubstantiated.The 1346 ...References1. Ernst E. A leading medical school seriously damaged: Vienna 1938. Ann Intern Med. 1995;122:789-92. LinkGoogle Scholar2. Park K. Doctors and Medicine in Early Renaissance Florence. Princeton, NJ: Princeton University Pr; 1985. Google Scholar3. Siraisi NG. Medieval and Early Renaissance Medicine. Chicago: University of Chicago Pr; 1990. Google Scholar4. Ruderman DB. Kabbalah, Magic and Science. Cambridge: Harvard University Pr; 1988. Google Scholar Author, Article, and Disclosure InformationAffiliations: Westwood, NJ 07675 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1995Volume 123, Issue 12Page: 963KeywordsAcademic medicineGraduate medical educationHeart rateJewish peoplePlagueUrine Issue Published: 15 December 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The case against inspiratory muscle training in COPD
Authors: M.I. Polkey, J. Moxham, M. Green
Journal: European Respiratory Journal (2011)

Despite maximal medical therapy, many chronic obstructive pulmonary disease (COPD) patients remain breathless and this has led to persistent and commendable efforts to reduce symptoms and improve exercise performance using nonpharmacological approaches; some of these, for example pulmonary rehabilitation (PR) 1, comprising general exercise and fitness training, are of proven benefit, while others remain controversial.

Inspiratory muscle training (IMT), being cheap and free of side-effects, is intuitively attractive, since improving the capacity of the inspiratory muscles should “make breathing easier” and so improve exercise performance. Enthusiasts do not allow the superficial attractiveness of this proposition to be clouded by aspects of the data. These are that the diaphragm is already working hard and well trained in emphysema, with a shift towards fatigue resistant type I fibres 2, that at a single fibre level it is energetically more efficient 3, that (allowing for hyperinflation) it is not actually weak 4, 5 and that diaphragm fatigue cannot be elicited in patients in vivo 6, 7, even when patients are sufficiently ill to require mechanical ventilation 8. The question of whether the respiratory muscles are weak in COPD seems particularly important in the context of IMT. In the current issue of the European Respiratory Journal , Gosselink et al. 9 cite our paper 5 as evidence that the diaphragm is weak; in fact, we concluded that the major reason for the reduced transdiaphragmatic pressures observed in COPD was hyperinflation, which of course would not be expected to improve with IMT. They also state that inspiratory …
HOMOLOGOUS BACTERIA AS A VACCINE IN TUBERCULOSIS.PRELIMINARY REPORT.
Authors: ALBERT H. ALLEN
Journal: JAMA (1907)

The object of this investigation was to obtain from sputum a standardized vaccine for tuberculosis. The product is called tubercle vaccine, since it resembles closely an emulsion of a tubercle. <h3>PREPARATION OF SPUTUM.</h3> Fresh sputum was carefully washed through six normal salt solutions. The sputum was then thoroughly homogenized with an ordinary egg-beater for from ten to fifteen minutes. An attempt was then made to separate the tubercle bacilli from the pus cells. Centrifugalizing, the whirling table, forced and simple filtering through many varieties of filter papers, through various cloths, sand, wool, cotton, glass wool, were tried with rather poor success. Thirteen layers of thin, closely-woven cloth with "threads drawn" and with the "drawn threads" parallel were used in the hope that the rods would pass more easily than the spherical cells through a filter with merely long narrow meshes. This made too coarse a filter. A fine sponge was
Off label prescribing to children in primary care in Germany: retrospective cohort study
Authors: R. Bucheler
Journal: BMJ (2002)

Between 35% and 90% of the drugs prescribed to hospitalised children are either not licensed for children's use or are prescribed outside the terms of their product licence (off label prescribing). 1 2Subsequent adverse reactions are more likely than with licensed products (6.0%v 3.9%). 3We analysed the extent of prescribing off labelled products in a representative cohort of children in primary care.
[411] INTERFERON-GAMMA (IFN-y)-INDUCIBLE INTRA-CELLULAR INACTIVATION OF HEPATITIS B VIRUS (HBV): COMPARISON OF APOBEC3 AND NITRIC OXIDE PATHWAYS
Authors: S. Phillips, J.A. Taylor, S. Chokshi, N. Navaratnam, N.V. Naoumov
Journal: Journal of Hepatology (2007)
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
Authors: Cinta Mestre-Escorihuela, Fanny Rubio-Moscardo, Jose A. Richter, Reiner Siebert, Joan Climent, Vicente Fresquet, Elena Beltran, Xabier Agirre, Isabel Marugan, Miguel Marín, Andreas Rosenwald, Kei-ji Sugimoto, Luise M. Wheat, E. Loraine Karran, Juan F. García, Lydia Sanchez, Felipe Prosper, Louis M. Staudt, Daniel Pinkel, Martin J. S. Dyer, Jose A. Martinez-Climent
Journal: Blood (2006)
Pancreatic Carcinoma and Palmar Fasciitis
Authors: Alan N. Baer, R. Macon Phillips
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 September 1983Pancreatic Carcinoma and Palmar FasciitisALAN N. BAER, M.D., R. MACON PHILLIPS JR., M.D.ALAN N. BAER, M.D.Search for more papers by this author, R. MACON PHILLIPS JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-3-411_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the article by Medsger and associates (1) on the occurrence of palmar fasciitis and polyarthritis in patients with ovarian carcinoma. We have recently cared for a woman who developed a similar paraneoplastic syndrome.In January 1981, a 62-year-old woman received 4500 rad of external beam irradiation for an unresectable adenocarcinoma of the pancreas with metastases to peripancreatic nodes. The patient became asymptomatic within several months and returned to work. In February 1982, the patient had pruritus of the thenar eminences and volar aspects of the wrists, progressing to paresthesias in the heel of...Reference1. MEDSGERDIXONGARWOOD TJV. Palmar fasciitis and polyarthritis associated with ovarian carcinoma. Ann Intern Med. 1982;96:424-31. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPalmar fasciitis and polyarthritis syndrome—Systematic literature review of 100 casesParaneoplastic Palmar Fasciitis and Polyarthritis Syndrome in a Patient With Advanced Prostate CancerPalmar Fasciitis and Polyarthritis Syndrome in Pancreatic CarcinomaA shoulder-hand syndrome revealing a lung cancerPalmar fasciitis and polyarthritis syndrome associated with transitional cell carcinoma of the bladderA paraneoplastic case of palmar fasciitis and polyarthritis syndromeIdiopathic Palmar Fasciitis with Polyarthritis SyndromeComplex regional pain syndrome type I in cancer patientsFlexion contractures associated with a malignant neoplasm: ‘A paraneoplastic syndrome?’IDIOPATHIC PALMAR FASCIITISThe fasciitis-panniculitis syndrome: Clinical spectrum and response to cimetidineConcept and limits of the reflex sympathetic dystrophyReflex sympathetic dystrophy associated with squamous cell carcinoma of the lung.Palmar fasciitis and arthritis with malignant neoplasms: A paraneoplastic syndromeReflex sympathetic dystrophy associated with malignancyReflex sympathetic dystrophy as a probable paraneoplastic syndrome: case report and literature review 1 September 1983Volume 99, Issue 3Page: 411-412KeywordsAdenocarcinomaArthritisPancreasPruritus Issue Published: 1 September 1983 PDF DownloadLoading ...
Tissue Changes in Lichen Selerosus et Atrophicus in Children following Local Application of Oestrogens.
Authors: E. F. Lascano, L. F. Montes, M. A. Mazzini
Journal: British Journal of Dermatology (1964)

Journal Article Tissue Changes in Lichen Selerosus et Atrophicus in Children following Local Application of Oestrogens. Get access E. F. Lascano, E. F. Lascano Mar del Plata, Argentina Search for other works by this author on: Oxford Academic Google Scholar L. F. Montes, L. F. Montes Houston, Texas Search for other works by this author on: Oxford Academic Google Scholar M. A. Mazzini M. A. Mazzini Buenos Aires, Argentina Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 11, 1 November 1964, Pages 496–497, https://doi.org/10.1111/j.1365-2133.1964.tb15496.x Published: 01 November 1964
DOES MILD AORTIC REGURGITATION IN PATIENTS POST-TRANSCATHETER AORTIC VALVE REPLACEMENT IMPACT MORTALITY?
Authors: Sa'ar Minha, Marco Magalhaes Pereira, Ricardo Escarcega Alarcon, Itsik Ben-Dor, Nevin Baker, Lakshmana Pendyala, Joshua Loh, Hideaki Ota, Omar Al Fazir, William Suddath, Lowell Satler, Petros Okubagzi, Fang Chen, Rebecca Torguson, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2014)
945 PROTEIN SILENCING OF HCV NS3 PROTEASE: A NEW SMALL MOLECULE APPROACH
Authors: M. Hagel, D. Niu, T. St. Martin, M. Sheets, L. Qiao, H. Bernard, P. Chaturvedi, M. Nacht, W. Westlin, R. Petter, J. Singh
Journal: Journal of Hepatology (2009)
Chest Medicine: Essentials of Pulmonary and Critical Care Medicine
Authors: David W. Cugell
Journal: JAMA (1991)

In the field of pulmonary medicine, as in other internal medicine subspecialties, there has been a proliferation of encyclopedic multivolume textbooks at correspondingly high costs. For those who prefer a boutique rather than the department store approach to a medical text, without relinquishing broad clinical coverage and at a reasonable price to boot, this one volume fits the bill. Noteworthy changes in the current edition, the first revision since the book was originally published in 1983, are a change in size with somewhat fewer but larger pages (although the type size is generous and the illustrations have "grown," the prior edition was easier to handle) and a slight rearrangement of chapter titles with a new section, "The Critically Ill Patient," for those interested in critical care. Unfortunately, there are few illustrations of computed tomographic images. This technology is widely used in all aspects of pulmonary disease, but it has barely
Dietary management of gastroenteritis
Authors: D. N K Symon, J. Stevenson, L. Pearson, P. G P Sanderson
Journal: BMJ (1988)

Finally, the authors report that their practice is to perform a laser cone biopsy when cytological abnormality persists or worsens after a normal colposcopic biopsy.We share their concern that women with abnormal cervical cytology should be rigorously followed up after a negative punch biopsy.As our paper questioned the effectiveness of colposcopically directed punch biopsy in ex- cluding disease, however, we believe that further information on the diagnostic yield of laser cone biopsy in these circumstances would be extremely valuable.
Adverse cutaneous reactions to the new second-generation tyrosine kinase inhibitors (dasatinib, nilotinib) in chronic myeloid leukemia
Authors: Livia Delgado, Stephane Giraudier, Nicolas Ortonne, Ouidad Zehou, Catherine Cordonnier, Anne Hulin, Olivier Chosidow, Michel Tulliez, Laurence Valeyrie-Allanore
Journal: Journal of the American Academy of Dermatology (2013)
Methylprednisolone Injections for the Carpal Tunnel Syndrome
Authors: Isam Atroshi, Jonas Ranstam
Journal: Annals of Internal Medicine (2013)

Letters17 December 2013Methylprednisolone Injections for the Carpal Tunnel SyndromeIsam Atroshi, MD, PhD and Jonas Ranstam, PhDIsam Atroshi, MD, PhDFrom Lund University, Lund, Sweden.Search for more papers by this author and Jonas Ranstam, PhDFrom Lund University, Lund, Sweden.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-12-201312170-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the interest in our randomized, double-blind, placebo-controlled trial that assessed the efficacy of a single injection of methylprednisolone in patients with CTS not previously treated with steroid injections. Dr. Ramirez-Lafita refers to findings derived from observational studies and 1 randomized, surgery-controlled study. As we highlighted in our article, the Cochrane review of “randomized or quasi-randomized studies” published up to May 2006 that aimed to “evaluate the effectiveness of local corticosteroid injection for carpal tunnel syndrome versus placebo injection or other non-surgical interventions” concluded that “local corticosteroid injection for carpal tunnel syndrome provides greater clinical improvement in ...Reference1. Marshall S, Tardif G, and Ashworth N. Local corticosteroid injection for carpal tunnel syndrome. Cochrane Database Syst Rev. 2007;:CD001554. [PMID: 17443508] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Isam Atroshi, MD, PhD; Jonas Ranstam, PhDAffiliations: From Lund University, Lund, Sweden.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M12-3068. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMethylprednisolone Injections for the Carpal Tunnel Syndrome Isam Atroshi , Magnus Flondell , Manfred Hofer , and Jonas Ranstam Methylprednisolone Injections for the Carpal Tunnel Syndrome Francisco Ramirez-Lafita Methylprednisolone Injections for the Carpal Tunnel Syndrome José Luis Andreu and Domingo Ly-Pen Metrics 17 December 2013Volume 159, Issue 12Page: 858-859KeywordsAtrophyComputed axial tomographyMusclesNervesObservational studiesSurgery ePublished: 17 December 2013 Issue Published: 17 December 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...