Cutaneous Manifestations of the Malignant Carcinoid Syndrome
Authors: CHARLES E. MENGEL
Journal: Annals of Internal Medicine (1963)

Case Studies1 June 1963Cutaneous Manifestations of the Malignant Carcinoid SyndromeSevere Pruritus and Orange BlotchesCHARLES E. MENGEL, M.D.CHARLES E. MENGEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-6-989 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCutaneous phenomena are the most characteristic and frequently recognized of the various clinical manifestations of the carcinoid syndrome. These occur as spontaneous or induced intermittent phenomena, a variety of colors being described (1-7). In addition, permanent changes with dilatation of capillaries and venules of the skin with a telangiectatic and permanent cyanotic appearance occur late in the course of the disease. These changes may be related in some way to increased circulating serotonin, histamine, or both. The occasional occurrence of pellagrinous cutaneous manifestations in these patients seems to be related to the development of niacin deficiency, secondary to both chronic...References1. BEANFUNK WBD: Vasculocardiac syndrome of metastatic carcinoid. Arch. Intern. Med. (Chicago) 103: 189, 1959. CrossrefGoogle Scholar2. KIERLANDSAUERDEARING RRWGWH: The cutaneous manifestations of the functioning carcinoid. Arch. Derm. (Chicago) 77: 86, 1958. CrossrefGoogle Scholar3. OATESSJOERDSMA JAA: A unique syndrome associated with secretion of 5-hydroxytryptophan by metastatic gastric carcinoids. Amer. J. Med. 32: 333, 1962. CrossrefMedlineGoogle Scholar4. SJOERDSMAWEISSBACHUDENFRIEND AHS: A clinical, physiologic and biochemical study of patients with malignant carcinoid (argentaffinoma). Amer. J. Med. 20: 520, 1956. CrossrefMedlineGoogle Scholar5. SJOERDSMAWEISSBACHTERRYUDENFRIEND AHLLS: Further observation on patients with malignant carcinoid. Amer. J. Med. 23: 5, 1957. 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MENGEL, M.D.Clinical and biochemical effects of cyclophosphamide in patients with malignant carcinoid 1 June 1963Volume 58, Issue 6Page: 989-993KeywordsAcademic medicineCapillariesCatheterizationExcretionHistamineMedical servicesNiacinSerotoninStenosisVenules ePublished: 1 December 2008 Issue Published: 1 June 1963 PDF downloadLoading ...