Post-Herpetic Erythema Multiforme Prevented with Prophylactic Oral Acyclovir
Authors: JON A. GREEN
Journal: Annals of Internal Medicine (1985)

Brief Reports1 May 1985Post-Herpetic Erythema Multiforme Prevented with Prophylactic Oral AcyclovirJON A. GREEN, M.D., Ph.D., SPOTSWOOD L. SPRUANCE, M.D., GAY WENERSTROM, R.N., MICHAEL W. PIEPKORN, M.D., Ph.D.JON A. GREEN, M.D., Ph.D., SPOTSWOOD L. SPRUANCE, M.D., GAY WENERSTROM, R.N., MICHAEL W. PIEPKORN, M.D., Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-632 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecurrent herpes simplex virus infection predisposes to the development of erythema multiforme in some persons (1) and can lead to a pattern of recurrent erythema multiforme and disabling morbidity. Recent reports of the safety and efficacy of oral acyclovir for the prophylaxis of recurrent herpes virus infections (2-4) suggest a similar application for the prevention of herpes virusrelated erythema multiforme.A 26-year-old white man, a professional housepainter, had recurrent labial herpes virus infections for 12 years with a stable pattern of three to five episodes a year. At age 24 he began having accelerated recurrences at monthly or bimonthly intervals....References1. ORTONHUFFTONNESSENWESTON PJMW. Detection of a herpes simplex viral antigen in skin lesions of erythema multiforme. Ann Intern Med. 1984;101:48-50. LinkGoogle Scholar2. WADENEWTONFLOURNOYMEYERS JBNJ. Oral acyclovir for prevention of herpes simplex virus reactivation after marrow transplantation. Ann Intern Med. 1984;100:823-8. LinkGoogle Scholar3. DOUGLASCRITCHLOWBENEDETTI JCJ. A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N Engl J Med. 1984;310:1551-6. CrossrefMedlineGoogle Scholar4. STRAUSSTABIFFSEIDLIN SHM. Suppression of frequently recurring genital herpes: a placebo-controlled double-blind trial of oral acyclovir. N Engl J Med. 1984;310:1545-50. CrossrefMedlineGoogle Scholar5. SPRUANCEOVERALLKERNKRUEGERPLIAMMILLER SJEGVW. The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. N Engl J Med. 1977;297:69-75. CrossrefMedlineGoogle Scholar6. SPRUANCE S. Pathogenesis of herpes simplex labialis: excretion of virus in the oral cavity. J Clin Microbiol. 1984;19:675-9. CrossrefMedlineGoogle Scholar7. KENNEDYLEIGHRIDGWAYWANSBROUGH-JONESBRIGDEN CIHMD. Treatment of erythema multiforme secondary to herpes simplex by prophylactic topical acyclovir. Br Med J. 1981;283:1360-1. CrossrefMedlineGoogle Scholar8. BACIGALUPOFRASSONIVAN LINT AFM. Acyclovir for the treatment of severe aplastic anemia [Letter]. N Engl J Med. 1984;310:1606-7. CrossrefMedlineGoogle Scholar9. RESNICKSCHLEIDER-KUSHNERHORWITZFROST LNSP. Remission of tumor-stage mycosis fungoides following intravenously administered acyclovir. JAMA. 1984;251:1571-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Utah School of Medicine Salt Lake City, Utah. 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