Vincristine Treatment of Severe Thrombocytopenia in Paroxysmal Nocturnal Hemoglobinuria
Authors: Akihiro Takeshita
Journal: Annals of Internal Medicine (1996)

Letters1 September 1996Vincristine Treatment of Severe Thrombocytopenia in Paroxysmal Nocturnal HemoglobinuriaAkihiro Takeshita, MD, Kazunori Ohnishi, MD, and Ryuzo Ohno, MDAkihiro Takeshita, MDHamamatsu University School of Medicine, Hamamatsu-shi, 431-31, JapanSearch for more papers by this author, Kazunori Ohnishi, MDHamamatsu University School of Medicine, Hamamatsu-shi, 431-31, JapanSearch for more papers by this author, and Ryuzo Ohno, MDHamamatsu University School of Medicine, Hamamatsu-shi, 431-31, JapanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Thrombocytopenia is common in patients with paroxysmal nocturnal hemoglobinuria (PNH) and is often severe enough to cause death. We describe a patient with paroxysmal nocturnal hemoglobinuria and severe thrombocytopenia in whom the latter condition was successfully treated with vincristine.A 51-year-old man was referred to us in March 1982 because of nocturnal hemoglobinuria and general fatigue. Lactate dehydrogenase levels were 1844 IU/L (isozymes I and II dominant pattern); the erythrocyte count was 3.91 million cells/µL; the hemoglobin level was 8.6 g/dL; the platelet count was 40 000 cells/µL; and the leukocyte count was 7600 cells/µL, with normal ...References1. Yamashita M. Inherited complete deficiency of 20-kilo-dalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1990; 323:1184-9. Google Scholar2. Miyata T, Yamada N, Iida Y, Nishimura J, Takeda J, Kitani T, et al. Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1994; 330:248-9. Google Scholar3. Pizzuto J, Ambriz R. Therapeutic experience on 934 adults with idiopathic thrombocytopenic purpura: multicentric trial of the cooperative Latin American Group on hemostasis and thrombosis. Blood. 1984; 64:1179-83. Google Scholar4. Moake JL. TTP-desperation, empiricism, progress. N Engl J Med. 1991; 325:426-8. Google Scholar5. Conti L, Iurlo A, Granolfo GM, Girelli G. Evans' syndrome in paroxysmal nocturnal hemoglobinuria. Acta Haematol. 1985; 73:210-1. Google Scholar Author, Article, and Disclosure InformationAuthors: Akihiro Takeshita, MD; Kazunori Ohnishi, MD; Ryuzo Ohno, MDAffiliations: Hamamatsu University School of Medicine, Hamamatsu-shi, 431-31, Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1996Volume 125, Issue 5Page: 424KeywordsBone marrow cellsFatigueGranulocytesHemoglobinHemorrhageIdiopathic thrombocytopenic purpuraLactate dehydrogenasePlateletsReticulocytesThrombotic thrombocytopenic purpura ePublished: 15 August 2000 Issue Published: 1 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...