tbuckley/cabot-search huggingface dataset:
TNF receptor gene therapy results in suppression of IgG2a anticollagen antibody in collagen induced arthritis
Authors: P Mukherjee
Journal: Annals of the Rheumatic Diseases (2003)

Therapeutic strategies to block tumour necrosis factor alpha (TNFalpha) activity in experimental autoimmune arthritis models and rheumatoid arthritis (RA) have proved highly successful, and provide sustained beneficial effects.To examine whether TNFalpha inhibition has immunological activity beyond the reduction of inflammation in collagen induced arthritis (CIA), an established experimental model of RA.Arthritic DBA/1 mice received single periarticular injections of retroviral constructs encoding human TNF receptor (TNF-R) into the affected arthritic paw, at the onset of arthritis. Severity of arthritis, antibodies to collagen type II (CII), and extent of pathological joint damage of arthritic paws were compared between TNF-R and media treated (control) animals 3, 7, 14, 21, and 49 days after disease onset.Severity of CIA was significantly decreased in TNF-R treated animals compared with controls, 14-34 days after disease onset. Joint destruction was reduced in TNF-R injected joints and in the uninjected contralateral and ipsilateral paws of TNF-R treated animals. Seven days after disease onset, TNF-R treated mice had lower levels of inflammatory Th1 driven IgG2a antibodies to CII (p<0.05) than controls. This altered the anticollagen IgG2a:IgG1 ratio towards Th2 driven IgG1.Local TNF-R gene therapy in CIA appears to have systemic effects on the anti-CII antibodies. The overall influence of TNF-R gene therapy is that it inhibits the progression of CIA mainly by suppressing the inflammatory Th1 response rather than by stimulating a Th2 response. Therefore, periarticular TNF-R gene therapy may have excellent therapeutic potential in RA.
Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells
Authors: Hiroshi Watarai, Shin-ichiro Fujii, Daisuke Yamada, Andrei Rybouchkin, Sakura Sakata, Yuko Nagata, Midori Iida-Kobayashi, Etsuko Sekine-Kondo, Kanako Shimizu, Yohei Shozaki, Jafar Sharif, Masashi Matsuda, Shinobu Mochiduki, Takanori Hasegawa, Genta Kitahara, Takaho A. Endo, Tetsuro Toyoda, Osamu Ohara, Ken-ichi Harigaya, Haruhiko Koseki, Masaru Taniguchi
Journal: Journal of Clinical Investigation (2010)

NKT cells demonstrate antitumor activity when activated to produce Th1 cytokines by DCs loaded with alpha-galactosylceramide, the prototypic NKT cell-activating glycolipid antigen. However, most patients do not have sufficient numbers of NKT cells to induce an effective immune response in this context, indicating a need for a source of NKT cells that could be used to supplement the endogenous cell population. Induced pluripotent stem cells (iPSCs) hold tremendous potential for cell-replacement therapy, but whether it is possible to generate functionally competent NKT cells from iPSCs has not been rigorously assessed. In this study, we successfully derived iPSCs both from embryonic fibroblasts from mice harboring functional NKT cell-specific rearranged T cell receptor loci in the germline and from splenic NKT cells from WT adult mice. These iPSCs could be differentiated into NKT cells in vitro and secreted large amounts of the Th1 cytokine IFN-gamma. Importantly, iPSC-derived NKT cells recapitulated the known adjuvant effects of natural NKT cells and suppressed tumor growth in vivo. These studies demonstrate the feasibility of expanding functionally competent NKT cells via an iPSC phase, an approach that may be adapted for NKT cell-targeted therapy in humans.
Intrauterine Devices and Acute Pelvic Inflammatory Disease
Authors: William L. Faulkner
Journal: JAMA (1976)

One of the most serious problems among women using the intrauterine device (IUD) has been pelvic inflammatory disease (PID). Subjects for the present investigation were chosen from 15- to 44-year-old women seeking emergency medical attention at a large city hospital. Febrile and afebrile patients with PID and appropriate controls were asked to complete a self-administered questionnaire concerning their demographic, reproductive, and contraceptive histories. Results showed a significantly higher proportion of IUD users among febrile cases of PID (38%) than among controls (11%). This implies that febrile PID is five times as likely to develop in an IUD user as in a nonuser. (<i>JAMA</i>235:1851-1853, 1976)
NOD2/CARD15 and the Paneth cell: another piece in the genetic jigsaw of inflammatory bowel disease
Authors: M C Aldhous
Journal: Gut (2003)

Expression of NOD2/CARD15 in the Paneth cell may be critical in the pathogenesis of Crohn’s disease

The emergence and application of novel molecular techniques over the last decade has provided a needed catalyst to studies of the pathogenesis of the chronic inflammatory bowel diseases (IBD): Crohn’s disease (CD) and ulcerative colitis (UC). Successful development of genetically engineered models of intestinal inflammation has not only provided insight into the dysregulation of the mucosal immune system characteristic of IBD but has also emphasised the critical and complex role of the bacterial flora in establishing and maintaining chronic intestinal inflammation.1 These advances in understanding pathophysiology in turn have already led to novel therapeutic approaches.2,3

However, it is in studies of human genetics that landmark progress has been made, widely recognised not only within gastroenterology but also by investigators in all complex diseases.4 Genome wide scanning led initially to the identification of a number of susceptibility loci, the statistical evidence for which satisfy stringent criteria for definite linkage.5 The subsequent detection of the NOD2/CARD15 gene6–8 within the IBD1 linkage interval and the association of mutations within this gene with susceptibility to CD is widely regarded as the most stringent proof of principle for hypothesis free genome scanning in complex diseases.

In the time that has elapsed since the discovery of NOD2/CARD15, the contribution of this gene in determining susceptibility and disease behaviour in IBD has received detailed examination. It is now clear that NOD2/CARD15 mutations are associated with susceptibility to CD but not UC.6 However, the contribution is subject to considerable ethnic and even regional variation. Whereas mutations may be carried by up to 50% of central Europeans with CD,9 these mutations are not present in Japanese10 or Afro-American11 patients. Even within Europe, …
Analysis of Choroidal Morphologic Features and Vasculature in Healthy Eyes Using Spectral-Domain Optical Coherence Tomography
Authors: Lauren A. Branchini, Mehreen Adhi, Caio V. Regatieri, Namrata Nandakumar, Jonathan J. Liu, Nora Laver, James G. Fujimoto, Jay S. Duker
Journal: Ophthalmology (2013)
Three-Phase Tc-99m MDP Scan Findings of a Soft Tissue Sarcoma
Authors: M PATRICIA BRAEUNING, HEE-MYUNG PARK
Journal: Clinical Nuclear Medicine (1990)

A 52-year-old woman presented to her orthopedic surgeon approximately five years after the onset of appearance of a right thigh mass which was at this point so large that it interfered with ambulation. A three-phase bone scan revealed a hypervascular mass with intense uptake in the calcified portion of the tumor and noninyolvement of the right femur. Surgical pathology was consistent with a monophasic synovial cell sarcoma. Synoyial cell sarcomas are uncommon malignancies. They arise from cells associated with the articular synovium or from those associated with the tendon sheath. Thirty percent show calcification on plain films. Many patients have distant metastases at the time of diagnosis. Synovial cell sarcoma should be included in the long list of soft tissue lesions that accumulate bone-scanning agents.
Arrhythmias After Infarction
Authors: JAMES E. MULLER
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 April 1972Arrhythmias After InfarctionJAMES E. MULLER, M.D.JAMES E. MULLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-4-669 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The conclusion of Moss and his co-workers in "Ventricular Arrhythmias 3 Weeks After Acute Myocardial Infarction" [Ann Intern Med 75:837-841, 1971] permits the findings of this valuable study to be misinterpreted.The occurrence of arrhythmias 3 weeks after a myocardial infarction was studied, using a 6-hour ECG-rhythm tape recording. Thirty-six percent of the patients showed a disturbing degree or type of ventricular irritability. The authors state that because the frequency of major ventricular premature contractions is remarkably similar to that recorded by Hinkle, Carver, and Stevens (1) in a normal healthy population, "it must be concluded that...Reference1. HINKLECARVERSTEVENS LSM: Frequency of asymptomatic disturbances of cardiac rhythm and conduction in middle-aged men. Am J Cardiol 24:629-650, 1969 CrossrefMedlineGoogle Scholar1. GIARDINABIGGERHEISSENBUTTEL EJR: Antiarrhythmic action of procainamide on ventricular arrhythmias (abstract). Circulation 44 (suppl II):86, 1971 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES E. MULLER, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1972Volume 76, Issue 4Page: 669-670KeywordsAcute myocardial infarctionArrhythmiaElectronic medical recordsInfarctionMyocardial infarction ePublished: 1 December 2008 Issue Published: 1 April 1972 PDF downloadLoading ...
Practice and Theory – The Present Situation
Authors: R.D. Laing
Journal: Psychotherapy and Psychosomatics (1965)

Research Articles| February 11 2010 Practice and Theory – The Present Situation Subject Area: Psychiatry and Psychology R.D. Laing R.D. Laing London Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1965) 13 (1-3): 58–67. https://doi.org/10.1159/000285756 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation R.D. Laing; Practice and Theory – The Present Situation. Psychother Psychosom 31 December 1965; 13 (1-3): 58–67. https://doi.org/10.1159/000285756 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1965Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
DERMATOLOGY IN TUDOR AND EARLY STUART ENGLAND
Authors: P. W. M. COPEMAN, W. S. C. COPEMAN
Journal: British Journal of Dermatology (1970)

Journal Article DERMATOLOGY IN TUDOR AND EARLY STUART ENGLAND Get access P. W. M. COPEMAN, P. W. M. COPEMAN Skin Department, Westminster Hospital, London, S.W.1, and Faculty of the History of Medicine, Worshipful Society of Apothecaries, Blackfriars Lane, London E.C.4 Search for other works by this author on: Oxford Academic Google Scholar W. S. C. COPEMAN W. S. C. COPEMAN Skin Department, Westminster Hospital, London, S.W.1, and Faculty of the History of Medicine, Worshipful Society of Apothecaries, Blackfriars Lane, London E.C.4 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 3, 1 March 1970, Pages 303–310, https://doi.org/10.1111/j.1365-2133.1970.tb12442.x Published: 01 March 1970
Strategies for the treatment of Hepatitis C in an era of interferon-free therapies: what public health outcomes do we value most?
Authors: Hamish Innes, David Goldberg, John Dillon, Sharon J Hutchinson
Journal: Gut (2014)

The expense of new therapies for HCV infection may force health systems to prioritise the treatment of certain patient groups over others. Our objective was to forecast the population impact of possible prioritisation strategies for the resource-rich setting of Scotland.We created a dynamic Markov simulation model to reflect the HCV-infected population in Scotland. We determined trends in key outcomes (e.g., incident cases of chronic infection and severe liver morbidity (SLM)) until the year 2030, according to treatment strategies involving prioritising, either: (A) persons with moderate/advanced fibrosis or (B) persons who inject drugs (PWID).Continuing to treat the same number of patients with the same characteristics will give rise to a fall in incident infection (from 600 cases in 2015 to 440 in 2030) and a fall in SLM (from 195 cases in 2015 to 145 in 2030). Doubling treatment-uptake and prioritising PWID will reduce incident infection to negligible levels (<50 cases per year) by 2025, while SLM will stabilise (at 70-75 cases per year) in 2028. Alternatively, doubling the number of patients treated, but, instead, prioritising persons with moderate/advanced fibrosis will reduce incident infection less favourably (only to 280 cases in 2030), but SLM will stabilise by 2023 (i.e., earlier than any competing strategy).Prioritising treatment uptake among PWID will substantially impact incident transmission, however, this approach foregoes the optimal impact on SLM. Conversely, targeting those with moderate/advanced fibrosis has the greatest impact on SLM but is suboptimal in terms of averting incident infection.
THE EFFECTS OF FUNCTIONAL GARMENT ON THE JUMP LANDING TASK
Authors: K Mukai, M Koyanagi, Y Kimura, N Nakae, T Ogawa, Y Yokotani, T Shioki, M Notani, T Hirama
Journal: British Journal of Sports Medicine (2014)

Background The effectiveness of wearing a brace to prevent sports injuries of the knee remains controversial. We examined the impact of functional newly developed garments. Objective To investigate the biomechanics of the knee joint when wearing the functional garment with lines in the fabric of different elasticities. Design Quasi-experimental. Setting Controlled laboratory setting. Participants 22 healthy male and female college students who participated in recreational sports. Interventions A single-leg drop jump onto the force plate was performed from a height of 30 cm. Infrared-reflective markers were attached to a total of 39 points for each subject. Body movements were tracked using a high-speed (200 Hz) three-dimensional motion analyzer and a force plate (ground reaction force of 1000 Hz). Long garments were used: two types of garments with fabric lines of hard and soft elasticity and the same garment with no processing (NT) as a control. Main outcome measurements External knee and knee valgus-varus moments as well as joint angle of the support leg were calculated using computer software. Results At 40 ms after ground contact, a significant decrease in the knee valgus angle was observed when wearing the Hard garment (5.33±3.32°) compared to the NT garment (1.33±4.91°; P&lt;.05). A significantly low knee valgus-varus moment was observed when wearing the Hard garment (–6.08±7.07 Nm/kg) compared with the NT garment (0.93±8.60 Nm/kg) (P&lt;.05). Conclusion The developed functional garment is considered to have reduced the knee abduction moment by controlling the knee valgus moment in a single-leg drop jump.The garment has the potential to avoid malalignment of the lower extremity and prevent sports injury of the knee joint.
Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread
Authors: Ping-Pui Wong, Fevzi Demircioglu, Essam Ghazaly, Wasfi Alrawashdeh, Michael R.L. Stratford, Cheryl L. Scudamore, Biancastella Cereser, Tatjana Crnogorac-Jurcevic, Stuart McDonald, George Elia, Thorsten Hagemann, Hemant M. Kocher, Kairbaan M. Hodivala-Dilke
Journal: Cancer Cell (2015)
Abstract 5318: LC-MS/MS quantification of proteins CD47 and SIRPA in cell subtypes selected by flow cytometry from blood
Authors: Carmen Fernandez-Metzler, Renold Capocasale
Journal: Cancer Research (2014)

Abstract Flow cytometry and mass spectrometry are widely used analytical tools in cancer research. Flow cytometry is known for cell counting, cell sorting and cancer biomarker discovery. Mass spectrometry is unparalleled in its ability to selectively detect and quantify target analytes at the molecular level. The combination of flow cytometry to isolate specific cell subtypes from biological fluids such as blood and mass spectrometry to quantify proteins contained in the selected cells provides a new approach to studying protein expression in specific cell subtypes. We have used this combination to investigate the normal levels of CD47 and SIRPA proteins in CB8+ T-cells, CD4+ T-cells, CD14+ monocytes, CD33+ myeloid cells and CD56+ NK cells isolated from blood specimens as a first step toward better understanding of how the CD47/SIRPA protein levels in these cells are affected by cancer and cancer treatment. Citation Format: Carmen Fernandez-Metzler, Renold Capocasale. LC-MS/MS quantification of proteins CD47 and SIRPA in cell subtypes selected by flow cytometry from blood. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5318. doi:10.1158/1538-7445.AM2014-5318
Upper Gastrointestinal Hemorrhage
Authors: Eddy D. Palmer
Journal: JAMA (1975)

AS one of the more desperate of medical emergencies, torrential upper gastrointestinal hemorrhage demands close teamwork between several medical workers: clinicians, nurses, radiologists, laboratory technicians, electrocardiographers, blood bank personnel, and chaplains. Because each may have an urgent job very soon after the patient arrives on the medical scene, a prescribed plan of action for immediate treatment is required if confusion and inefficiency are to be avoided. On the other hand, the many clinical variables encountered among bleeding patients, particularly as they pertain to the preexisting base line medical situation, necessitate the most thoughtful individualization in the treatment of each patient. In upper gastrointestinal hemorrhage the bleeding source lies somewhere proximal to the third portion of the duodenum. Thus, by definition, the source of upper gastrointestinal hemorrhage may be reached by routine peroral panendoscopy. This is an especially important point: it explains why arteriography is ordinarily not employed for diagnosis, even
Plasma asymmetric dimethylarginine is related to anticitrullinated protein antibodies in rheumatoid arthritis of short duration
Authors: Andrzej Surdacki, Jens Martens-Lobenhoffer, Alicja Wloch, Piotr Gluszko, Tomasz Rakowski, Jacek S. Dubiel, Stefanie M. Bode-Böger
Journal: Metabolism (2009)
Adverse pregnancy outcomes after treatment for cervical intraepithelial neoplasia
Authors: M. Jakobsson, F. Bruinsma
Journal: BMJ (2008)

<h3>Background</h3> Both bisphosphonates and testosterone are known to improve bone mineral density (BMD) in men with low bone mass, but whether combination therapy is superior to these agents used alone is not clear. We compared the changes in lumbar spine BMD when men with low bone mass were treated with each agent alone or as combination therapy. <h3>Methods</h3> In a retrospective study, we analyzed serum and BMD data from 149 men who had been evaluated in the Endocrinology Clinic at the Dallas Veterans Affairs Medical Center, Dallas, Texas. The subjects were divided into three cohorts: 59 men receiving testosterone therapy alone, 68 men receiving alendronate therapy alone, and 22 receiving combination therapy. <h3>Results</h3> Compared with the baseline values, the lumbar spine and BMD increased significantly in each of the testosterone, alendronate, and combination therapy cohorts (median annualized rate of change: 2.1% [<i>p</i> &lt; .001], 2.6% [<i>p</i> &lt; .001], and 2.5% [<i>p</i> = .04], respectively). The combination therapy group did not demonstrate any additional increase in BMD at the lumbar spine or total hip compared with either agent alone. The results did not change after adjusting for differences in baseline weight, age, BMD, or baseline testosterone level. <h3>Conclusion</h3> The results suggest that the combination of testosterone and alendronate does not appear to be superior to single-drug therapy in our patient population.
Tryptophan Metabolism in Phenylketonurics
Authors: Frederick A. Reichle
Journal: JAMA (1961)

ALTHOUGH the genetic defect in the hereditary disorder phenylketonuria has been related to the lack of one of the enzymes involved in the hydroxylation of phenylalanine, the cause of the mental retardation remains unknown.  Bickel et al. 1 and other workers noted dramatic improvement in intelligence and developmental quotients of certain phenylketonuric children who were fed diets low in phenylalanine content. Concomitantly, the blood phenylalanine levels of these children fell to within the range found in normal children. Hence, the mental retardation has been attributed to some metabolic disorder associated with elevated blood and tissue levels of phenylalanine.  Armstrong et al. 2 found that phenylketonurics excrete more of certain tryptophan metabolites, such as indoleacetic acid, than do normal children, and Pare et al. 3 later showed that the blood levels of 5-hydroxytryptamine (serotonin) were lower, and the urinary excretion of 5-hydroxyindoleacetic acid was less, in phenylketonurics than in other mentally