tbuckley/cabot-search huggingface dataset:
Simple Bedside Additive Tool for Prediction of In-Hospital Mortality After Percutaneous Coronary Interventions
Authors: Mauro Moscucci, Eva Kline-Rogers, David Share, Michael O’Donnell, Ann Maxwell-Eward, William L. Meengs, Phillip Kraft, Anthony C. DeFranco, James L. Chambers, Kirit Patel, John G. McGinnity, Kim A. Eagle
Journal: Circulation (2001)

Background Risk-adjustment models for percutaneous coronary intervention (PCI) mortality have been recently reported, but application in bedside prediction of prognosis for individual patients remains untested. Methods and Results Between July 1, 1997 and September 30, 1999, 10 796 consecutive procedures were performed in a consortium of 8 hospitals. Predictors of in-hospital mortality were identified by use of multivariate logistic regression analysis. The final model was validated by use of the bootstrap technique. Additional validation was performed on an independent data set of 5863 consecutive procedures performed between October 1, 1999, and August 30, 2000. An additive risk-prediction score was developed by rounding coefficients of the logistic regression model to the closest half-integer, and a visual bedside tool for the prediction of individual patient prognosis was developed. In this patient population, the in-hospital mortality rate was 1.6%. Multivariate regression analysis identified acute myocardial infarction, cardiogenic shock, history of cardiac arrest, renal insufficiency, low ejection fraction, peripheral vascular disease, lesion characteristics, female sex, and advanced age as independent predictors of death. The model had excellent discrimination (area under the receiver operating characteristic curve, 0.90) and was accurate for prediction of mortality among different subgroups. Near-perfect correlation existed between calculated scores and observed mortality, with higher scores associated with higher mortality. Conclusions Accurate predictions of individual patient risk of mortality associated with PCI can be achieved with a simple bedside tool. These predictions could be used during discussions of prognosis before and after PCI.
One-Year Follow-up of Posterior Chamber Toric Phakic Intraocular Lens Implantation for Moderate to High Myopic Astigmatism
Authors: Kazutaka Kamiya, Kimiya Shimizu, Daisuke Aizawa, Akihito Igarashi, Mari Komatsu, Akio Nakamura
Journal: Ophthalmology (2010)
Phencyclidine Pharmacokinetics after a Massive Overdose
Authors: J. Edward Jackson
Journal: Annals of Internal Medicine (1989)

Excerpt Phencyclidine abuse remains a major problem particularly in urban centers. Regarding the management of phenycyclidine intoxication, recommendations have been made to hasten elimination of phencyclidine by urine acidification (1-3). However, more recent pharmacokinetic studies suggest that phencyclidine is cleared primarily by metabolism and has a large volume of distribution (6.2 L/kg) (4, 5). The pharmacokinetics of phenyclidine after massive overdosage have not been characterized. This report details the time course of plasma phencyclidine concentrations in a patient who had severe symptoms after massive overdosage. These phencyclidine levels represent the highest ever reported for a survivor of phencyclidine intoxication. Case Report
P17.46 * LATE PSEUDOPROGRESSION IN GLIOBLASTOMA PATIENTS: COMPARABLE ANALYSIS WITH REAL TUMOR PROGRESSION
Authors: S. Kamer, O. Akagunduz, Y. Ertan, T. Akal n, E. Ozgiray, K. Oner, C. Eraslan, C. Call , N. Oktar, Y. Anacak
Journal: Neuro-Oncology (2014)

PURPOSE: Pseudoprogression is defined among the glioblastoma (GBM) patients as clinical deterioration and/or radiological enlargement and contrast enhancement after radiochemotherapy which resolves during the follow-up. It is typically detected within 3 months after radiochemotherapy. Late pseudoprogression is not common and not clearly defined yet. We analyzed 33 patients who were reoperated for clinical/radiological progression after chemoradiotherapy and compared the clinicopathologic characteristics of the patients without any histologic evidence of tumor with those having real tumor progression. MATERIAL AND METHODS: We identified histologically verified GBM patients who underwent a second tumor resection after radiochemotherapy due to clinical deterioration and/ or radiologically progression between January 2010- October 2013. All pathological specimens were evaluated in our center and were separated in two groups; GroupA: real recurrence of GBM, Group B:late pseudo progression, either no evidence of tumor, complete necrosis or treatment related changes reminding tumor regression. We determined survival after primary surgery and re-resection with regard to pathological results using Kaplan-Meier estimates. RESULTS: 33 patients were included in this study. Median age was 51 (range:17-72), male/female ratio was 2.3/1. After the radiochemotherapy, clinical deterioration and/ or radiologically progression was detected median 10 months later (range: 4-22months).After the secondary surgery, 18 patients (55%) showed late pseudoprogression but 15 patients (45%) experienced real tumor recurrence in the pathological evaluation. From the diagnosis, 2-year survival rate was 26.3% in whole group. 2-year survival rate was 36% in patients who had late pseudoprogression and 16.7% in patients who had real tumor progression (p:0,45). After the secondary surgery, 2 year survival rate was 11% in cases with late pseudoprogression and median survival was 9 months (range:4-28 months). In patients who experienced real tumor recurrence, 2-year survival after secondary surgery was%0 and median survival was 4 months (range: 2-12 months) . Median time to recurrence was 9 months (range :5-22 months) in patients with late pseudoprogression but 11 months (range:4-18 months) in patients experienced real tumor recurrence. CONCLUSION: GBM patients occasionally undergone reoperation due to clinical deterioration or radiological progression, however no evidence of tumor is found in some cases which may be defined as late pseudoprogression. The survival of these patients are better than the cases with tumor progression.
The Cost of NOT Doing Medical Research
Authors: William C. Gibson
Journal: JAMA (1979)

As the elderly lady said when the collection plate was passed to her in church, "I have nothing but praise for the new minister." Her sentiments have been echoed by many governments ever since, with nothing but praise for medical research. It is a shame to see medical research treated as a charity—as merely a good work in a naughty world. That day must surely be over, as is the era of medical research as a "hobby." The very idea that a research career might be possible, even defensible, was foreign to the 19th century. In this century, however, one is not castigated for proclaiming, as Banting did, that medical research could be a worthy and rewarding career. To view the research career otherwise would be to deny the continuity that clearly exists between its devotees today and Hippocrates. As Osler remarked: "So far did unaided observation and brilliant generalization
Development of gas-exchange surface area in rat lung. The effect of alveolar shape.
Authors: L N Blanco, L Frank
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

During development, the surface area of the gas-exchange region of the lung can increase by: (1) expansion, (2) subdivision (septation), (3) replication, or (4) change of shape of the basic gas-exchange units (saccules or alveoli). We evaluated the shape of these units in rat lung from birth to adulthood. A shape factor (phi g) was defined in terms of the surface area (Sg) and the volume (Va) of the average unit, using the expression phi g = SgVa-2/3. We studied the lungs of untreated animals and of animals exposed to or treated with hyperoxia (> 95% O2) and/or dexamethasone, each of which is known to inhibit septation in early postnatal life, and with deferoxamine, which protects the lung against the inhibitory effect of hyperoxia. The values found for the shape factor showed no significant difference with regard to age or treatment. This finding suggests that: (1) saccules and alveoli are formed with a certain predetermined shape (close to a hemisphere), (2) any enlargement with time is isotropic, (3) alveolar shape is insensitive to the drastic treatments used, and (4) change of shape is not a mechanism used to increase the gas-exchange surface area of the developing rat lung.
Recommendations for intensive care unit and hospital preparations for an influenza epidemic or mass disaster: summary report of the European Society of Intensive Care Medicine’s Task Force for intensive care unit triage during an influenza epidemic or mass disaster
Authors: Charles L. Sprung, Janice L. Zimmerman, Michael D. Christian, Gavin M. Joynt, John L. Hick, Bruce Taylor, Guy A. Richards, Christian Sandrock, Robert Cohen, Bruria Adini
Journal: Intensive Care Medicine (2010)
Abul Quasem Syed Mohammed Harun
Authors: S. Harun
Journal: BMJ (2001)

Obstetrician and gynaecologist who worked with Fleming on the role of penicillin in treating venereal diseaseDuring the second world war Jack Suchet was initially retained at St Mary's, where he was not only registrar in the department of obstetrics but also became assistant and then director of the department of venereology.He became adviser in venereology to the war office and because of this appointment he worked closely with Sir Alexander Fleming on the role of penicillin in the revolutionary
Memory function of fatty acid metabolism imaging for detecting post-ischemic myocardium in unstable angina: a comparison with ECG changes and wall motion
Authors: S. Nishimura, Y. Ohta, K. Katoh, T. Tamaki, K. Yumoto, Y. Soezima, T. Ueda, T. Shimamoto
Journal: Journal of the American College of Cardiology (1998)
Non-tumoral stenosis of the aqueduct in adults.
Authors: T. K. Nag, M. A. Falconer
Journal: BMJ (1966)

conclude that there was an increased protein exudation into the bowel in Cases 1 and 3 (see Table ).1The normal values for faecal excretion of 131I and 55Cr quoted in the Table agree with those reported by Gordon (1959) and Schwartz and Jarnum (1959) for 13 I-P.V.P. and by Rubini and Sheehy (1961) and Rubini et al. (1961) for 51CrCl 3. How- ever, in the former two reports faecal recovery of '31I-P.V.P. in control subjects was occasionally as high as 1.5% and 1.03% respectively, while in the study by Rubini and Sheehy (1961) faecal recovery of 'Cr was up to 1 %.The excretion of 1.3 % of the injected isotope in Case 4 cannot therefore be regarded as abnormal.However, the excretion of 2.4 % of the administered dose in Case 5 may well be abnormally high, although the serum albumin level was normal.In this patient albumin production had presumably increased enough to pre- vent hypoalbuminaemia, as in some of the patients studied by Jeejeebhoy (1964).It is very unlikely that loss of blood into the bowel entirely accounted for the recovery of isotope in the faeces.Bleeding did not occur in Case 1 during the IIII-P.V.P. test, daily tests for occult blood in the stools being consistently negative.Hypoalbuminaemia was present in Case 2 before gastro- intestinal bleeding was detected.No bleeding occurred in Case 5 but the faecal recovery of isotope was elevated.Moreover, far larger haemorrhages due to diseases such as peptic ulcer do not usually produce hypoalbuminaemia.
Characterizing the 12 Amb a 1-U Ragweed Allergy Immunotherapy Tablet Adverse Event Profile in Adults with Ragweed-Induced Allergic Rhinoconjunctivitis
Authors: Jennifer Maloney, Gary D. Berman, David I. Bernstein, Bobby Q. Lanier, Amarjot Kaur, Nancy Liu, Hendrik Nolte
Journal: Journal of Allergy and Clinical Immunology (2013)
Differential <sup>18</sup> F-2-Deoxyglucose Uptake in Viable Dysfunctional Myocardium With Normal Resting Perfusion
Authors: James A. Fallavollita, John M. Canty
Journal: Circulation (1999)

Background —Viable, chronically dysfunctional myocardium can have normal or reduced resting flow. We previously produced hibernating myocardium with reduced resting flow in pigs with a chronic stenosis and hypothesized that hibernation is preceded by chronic stunning with normal resting perfusion. Methods and Results —Pigs instrumented with a proximal left anterior descending coronary artery (LAD) stenosis were studied 1 or 2 months later in the closed-chest anesthetized state. Stenosis severity increased from 74±5% at 1 month to 83±6% at 2 months and was accompanied by anteroapical hypokinesis (wall motion score, 2.1±0.1 at 1 month and 1.5±0.3 at 2 months; normal=3). Resting perfusion was similar in normal and dysfunctional regions, but the deposition of 18 F-2-deoxyglucose (FDG) varied. At 1 month, subendocardial FDG deposition by excised tissue counting was similar in each region (0.034±0.006 mL · g −1 · min −1 LAD region versus 0.032±0.004 mL · g −1 · min −1 in normal regions, P =NS). At 2 months, subendocardial FDG deposition was increased (0.084±0.025 mL · g −1 · min −1 LAD region versus 0.042±0.017 mL · g −1 · min −1 in normal regions, P &lt;0.05). Increases in FDG uptake were inversely related to LAD subendocardial flow reserve during adenosine (3.5±0.6 at 1 month versus 1.4±0.2 at 2 months, P &lt;0.01). Conclusions —These data indicate a progression of physiological adaptations in pigs with viable, chronically dysfunctional myocardium. As coronary flow reserve decreases, fasting FDG uptake increases. Flow at rest remains normal, consistent with “chronic stunning,” and contrasts with reduced flow and increased FDG characteristic of hibernating myocardium in similarly instrumented pigs after 3 months. This temporal progression of adaptations supports the hypothesis of a transition from a physiological phenotype of stunning to hibernation.
Rehabilitation of Concentration Camp Survivors (Following Concentration Camp Trauma)
Authors: L. Eitinger
Journal: Psychotherapy and Psychosomatics (1969)

Research Articles| February 12 2010 Rehabilitation of Concentration Camp Survivors (Following Concentration Camp Trauma) Subject Area: Psychiatry and Psychology L. Eitinger L. Eitinger Oslo Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1969) 17 (1): 42–49. https://doi.org/10.1159/000286009 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation L. Eitinger; Rehabilitation of Concentration Camp Survivors (Following Concentration Camp Trauma). Psychother Psychosom 1 January 1969; 17 (1): 42–49. https://doi.org/10.1159/000286009 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1969Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Adverse outcomes prior to hospital discharge after primary stenting for acute myocardial infarction are often predictable, and related to correctable technical factors
Authors: G.W. Stone, B. Brodie, J. Griffin, M.C. Morice, F.S. Goar, C. Costantini, P.A. Overlie, J. Popma, W.W. O'Neill, C.L. Grines
Journal: Journal of the American College of Cardiology (1998)
Interleukin 3 (IL-3) induces transcription from nonrearranged T cell receptor gamma loci in IL-3-dependent cell lines.
Authors: Y Weinstein, K Morishita, J L Cleveland, J N Ihle
Journal: The Journal of Experimental Medicine (1989)

The expression of the murine TCR-gamma genes was examined in a series of IL-3-dependent and growth factor-independent cell lines. All of the IL-3-dependent cell lines, but none of the IL-3-independent lines, expressed high levels of one or more of the gamma genes but did not express the TCR-beta genes. None of the cell lines expressing the gamma loci contained detectable genomic gamma gene rearrangements. Sequencing of cDNA clones from two of the cell lines demonstrated that transcription was from nonrearranged gamma loci based on the presence of sequences in the cDNAs that are found immediately 5' of the J gamma 4 and J gamma 2 genes. The expression of gamma transcripts was dependent upon IL-3 and no transcripts were detectable within 6-8 h after the removal of IL-3. Readdition of IL-3, but not granulocyte CSF, resulted in the reappearance of gamma transcripts within 30 min. The results demonstrate that IL-3 regulates the expression of nonrearranged gamma loci. Since expression is required for rearrangement, it can be hypothesized that IL-3 may influence the ability of lymphoid/myeloid progenitors to commit to the T cell lineage.
Comparison of direct and indirect methods of estimating health state utilities for resource allocation: review and empirical analysis
Authors: D. Arnold, A. Girling, A. Stevens, R. Lilford
Journal: BMJ (2009)

<b>Background and objective</b> Utilities (values representing preferences) for healthcare priority setting are typically obtained indirectly by asking patients to fill in a quality of life questionnaire and then converting the results to a utility using population values. We compared such utilities with those obtained directly from patients or the public. <b>Design</b> Review of studies providing both a direct and indirect utility estimate. <b>Selection criteria</b> Papers reporting comparisons of utilities obtained directly (standard gamble or time trade off) or indirectly (European quality of life 5D [EQ-5D], short form 6D [SF-6D], or health utilities index [HUI]) from the same patient. <b>Data sources</b> PubMed and Tufts database of utilities. <b>Statistical methods</b> Sign test for paired comparisons between direct and indirect utilities; least squares regression to describe average relations between the different methods. <b>Main outcome measures</b> Mean utility scores (or median if means unavailable) for each method, and differences in mean (median) scores between direct and indirect methods. <b>Results</b> We found 32 studies yielding 83 instances where direct and indirect methods could be compared for health states experienced by adults. The direct methods used were standard gamble in 57 cases and time trade off in 60 (34 used both); the indirect methods were EQ-5D (67 cases), SF-6D (13), HUI-2 (5), and HUI-3 (37). Mean utility values were 0.81 (standard gamble) and 0.77 (time trade off) for the direct methods; for the indirect methods: 0.59 (EQ-5D), 0.63 (SF-6D), 0.75 (HUI-2) and 0.68 (HUI-3). <b>Discussion</b> Direct methods of estimating utilities tend to result in higher health ratings than the more widely used indirect methods, and the difference can be substantial. Use of indirect methods could have important implications for decisions about resource allocation: for example, non-lifesaving treatments are relatively more favoured in comparison with lifesaving interventions than when using direct methods.
Editorial: Immaterial to diagnosis
Authors: S. Vaisrub
Journal: JAMA (1975)

We know that chivalry is of the past, but what about gallantry? Does it still find a place in modern society? Women's liberation has opened our eyes to the sinister implications of what men always thought to be gallant acts and words. They sense condescension, even disdain, in a man's exaggerated courtesy, oversolicitous attentiveness, and ornate compliments. They resent being looked upon as "pleasure objects." This resentment is reflected in a recent comment by Cherill M. Parmentier-Perera.<sup>1</sup>"Should a female," she queries, referring to a previous article, "be reported as 'attractive' on physical examination?... the adjective is immaterial to diagnosis." And she goes on to say, tongue in cheek: "Perhaps, the letter on page 858 of the same issue should be appended to read 'a 52-year-old handsome male school bus driver.' " "Handsome," however, is not the exact male counterpart to "attractive." The former appeals to aesthetic sensibilities, the latter
Human Hemoglobin Types
Authors: James V. Neel
Journal: New England Journal of Medicine (1957)

ONE privileged to deliver such a lecture as this is almost inevitably led to look back over the topics selected by his predecessors. The Cutter Lectures on Preventive Medicine have been an extraordinarily diverse lot; yet all that I have consulted have dealt with well-recognized aspects of the field of public health. At first glance, it would seem doubtful if the same thing can be said of the subject under consideration. Perhaps, then, I should state at the outset that in this discussion of inherited human hemoglobin types, I shall be far less concerned with the technical differentiation and the . . .
A controlled trial of photochemotherapy for persistent palmoplantar pustulosis
Authors: D. MURRAY, M. F. CORBETT, A. P. WARIN
Journal: British Journal of Dermatology (1980)

Twenty-two patients with bilaterally symmetrical persistent palmoplantar pustulosis were treated on one randomly selected side with oral psoralen and long-wave ultraviolet light. The treated side cleared completely in twelve patients, almost cleared in five patients and improved in four. One patient improved on both sides. Fifteen of the twenty-two patients were then treated with topical psoralen and long-wave ultraviolet light on the side that had previously been used as a control. Similar results were obtained. Seven patients cleared completely, six patients were much improved and two were improved. These results are significantly different from those liable to occur by chance (P > 0.001).