tbuckley/cabot-search huggingface dataset:
Acid Production in Diabetic Acidosis; a More Rational Approach to Alkali Replacement
Authors: P. Z. Zimmet, P. Taft, G. C. Ennis, J. Sheath
Journal: BMJ (1970)

The production of organic acids in severe diabetic acidosis was studied to determine the contribution of various acids and to reassess alkali requirements. In 11 patients the mean total concentration of determined organic acids was 16 mEq/l., while the mean estimated base deficit was 24 mEq/l. Acetoacetic and β-hydroxybutyric acids accounted for 75% of measured organic acid. In 10 patients the mean amount of sodium bicarbonate administered for correction of the acidosis was 185 mEq, while the mean requirement was 394 mEq. These findings imply that the methods commonly used to determine the base deficit and the alkali requirements in patients with diabetic acidosis may be invalid. The prompt administration of alkali should be limited, and we suggest that the blood <i>p</i>H should be restored only to 7·25.
Pigmented villonodular synovitis in multiple joints. Occurrence in a child with cavernous haemangioma of lip and pulmonary stenosis.
Authors: J Leszczynski,, J R Huckell, J S Percy, J C LeRiche, B C Lentle
Journal: Annals of the Rheumatic Diseases (1975)

A case is presented of pigmented villonodular synovitis involving three joints in a 7-year-old girl. The diagnosis was confirmed at surgery and by histology. The patient also exhibited a haemangioma of the upper lip and a congenital pulmonary stenosis of mild degree. Subtotal synovectomy of the right knee and of both ankles was performed. The lesion recurred in both ankles after 6 months. Review of the literature failed to reveal any previous report of multiple joint involvement by pigmented villonodular synovitis in childhood and it appears that simultaneous involvement of three joints has not previously been described. Scintiscanning with 99mTc stannous pyrophosphate showed increased vascularity of the involved joints immediately after injection, but no increased osteoblastic activity was seen on the delayed scan. This radionuclide scanning technique is therefore helpful in distinguishing pigmented villonodular synovitis from other arthropathies.
Psychological and Sexual Aspects in Different Types of Bladder Dysfunction
Authors: R.L. Vereecken
Journal: Psychotherapy and Psychosomatics (1989)

Different types of dysfunctional voiding are described and correlated with psychological characteristics and sexual dysfunctions. Motoric as well as sensoric urge incontinence seems to be more frequently associated with psychological problems than stress incontinence and a psychosomatic therapy often results in cure without any surgery. A multidisciplinary approach to the problem is stressed.
The diagnosis of acute, recurrent, deep-vein thrombosis: a diagnostic challenge.
Authors: R D Hull, C J Carter, R M Jay, P A Ockelford, J Hirsch, A G Turpie, A Zielinsky, M Gent, P J Powers
Journal: Circulation (1983)

Recurrent venous thrombosis presents a diagnostic challenge. Venography, impedance plethysmography and fibrinogen leg scanning all have potential limitations, and their role in this context has not been evaluated. We performed a prospective cohort study evaluating impedance plethysmography and leg scanning, plus venography, using outcome on long-term follow-up as the end point in 270 patients with clinically suspected recurrent deep-vein thrombosis. Anticoagulant treatment was withheld in the 181 patients negative by noninvasive testing and was given in patients positive by impedance plethysmography if leg scanning was positive or if intraluminal filling defects were detected by venography. The validity of this approach was tested by long-term follow-up. Three of 181 patients (1.7%) negative by noninvasive testing had a recurrence, compared with 18 of 89 (20%) with positive findings (p less than 0.001). Our objective diagnostic approach has high clinical utility; an objective rationale for withholding or giving treatment was established in 95% of patients.
Aeromonas-Associated Diarrhea in the Netherlands
Authors: E. J. Kuijper, H. C. Zanen, M. F. Peeters
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 April 1987Aeromonas-Associated Diarrhea in the NetherlandsE. J. KUIJPER, M.D., H. C. ZANEN, M.D., M. F. PEETERS, M.D.E. J. KUIJPER, M.D.Search for more papers by this author, H. C. ZANEN, M.D.Search for more papers by this author, M. F. PEETERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-4-640_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Some of our results differ with those in the article on aeromonas intestinal infections (1). Between June 1982 and June 1986 we cultured all fecal samples that were submitted to the Regional Public Health Laboratory in Tilburg forAeromonas. Unlike in the study of Holmberg and associates, we used a semiselective blood agar plate with ampicillin, 10 mg/L (2), with which we could detect small numbers ofAeromonasin fecal samples as well. When a fecal sample containedAeromonas, the patient and the physician were contacted and asked for clinical data and a repeated fecal culture (3)....References1. HOLMBERGSCHELLFANNING SWG. Aeromonas intestinal infections in the United States. Ann Intern Med. 1986;105:683-9. LinkGoogle Scholar2. BURKEGRACEYROBINSONPECKBEAMONBUNDELL VMJDJC. The microbiology of childhood gastroenteritis: Aeromonas species and other infective agents. J Infect Dis. 1983;148:68-74. CrossrefMedlineGoogle Scholar3. KUIJPERPEETERS EM. De betekenis van verschillende Aeromonas soorten in de faeces van patienten met en zonder diarree. Ned Tijdschr Geneeskd. 1986;130:302-5. MedlineGoogle Scholar4. POPOFF M. Aeromonas. In: KRIEG NR, HOLT JG, eds. Bergey's Manual of Systemic Bacteriology. Vol. 1. Baltimore: Williams & Wilkins; 1984:545-8. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMolecular characterisation, genotyping and survival of Aeromonas hydrophila isolated from milk, dairy products and humans in EgyptAeromonas, Arcobacter, and PlesiomonasPCR Detection, Characterization, and Distribution of Virulence Genes in Aeromonas sppIsolation of carbohydrate-reactive outer membrane proteins of Aeromonas hydrophilaHuman serum antibody response to the presence of Aeromonas spp. in the intestinal tractClinical and epidemiologic aspects of members of Aeromonas DNA hybridization groups isolated from human fecesAeromonas As A Human Pathogen 1 April 1987Volume 106, Issue 4Page: 640-641KeywordsBloodDiarrheaPrevention, policy, and public healthResearch laboratories Issue Published: 1 April 1987 PDF downloadLoading ...
Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells
Authors: Josep Domingo-Domenech, Samuel J. Vidal, Veronica Rodriguez-Bravo, Mireia Castillo-Martin, S. Aidan Quinn, Ruth Rodriguez-Barrueco, Dennis M. Bonal, Elizabeth Charytonowicz, Nataliya Gladoun, Janis de la Iglesia-Vicente, Daniel P. Petrylak, Mitchell C. Benson, Jose M. Silva, Carlos Cordon-Cardo
Journal: Cancer Cell (2012)
In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents.
Authors: Y Liang, S Bonner-Weir, Y J Wu, C D Berdanier, D K Berner, S Efrat, F M Matschinsky
Journal: Journal of Clinical Investigation (1994)

The present study evaluated the involvement of glucose transport and phosphorylation in glucose-stimulated insulin release from pancreatic islets. Using quantitative histochemical techniques, we investigated basal islet glucose content, islet glucose uptake in situ during acute extreme experimental hyperglycemia, and islet glucokinase activity in several animal models of diabetes and obesity. The basal islet glucose content in anaesthetized diabetic or obese rodents was either the same or higher than that in their relevant controls. The rate of glucose uptake of islet tissue in these animals after an i.v. glucose injection was different. The db+/db+ mouse and the obese Zucker rat exhibited significantly reduced islet glucose uptake rates. RIP-cHras transgenic mice, BHE/cdb rats and partially pancreatectomized rats showed normal islet glucose uptake rates. The activity of islet glucokinase was increased to a different degree related to the blood glucose level. All five animal models of diabetes or obesity exhibited either a delay or a reduction of insulin release in response to supra maximal glucose stimulation. Our results indicate that the impairment of glucose-induced insulin release in diabetes is not consistently associated with a reduction of islet glucose uptake nor a change of glucokinase activity.
Norms and high-level cognition: Consequences, trends, and antidotes
Authors: Simon McNair, Aidan Feeney
Journal: Behavioral and Brain Sciences (2011)

Abstract We are neither as pessimistic nor as optimistic as Elqayam &amp; Evans (E&amp;E). The consequences of normativism have not been uniformly disastrous, even among the examples they consider. However, normativism won't be going away any time soon and in the literature on causal Bayes nets new debates about normativism are emerging. Finally, we suggest that to concentrate on expert reasoners as an antidote to normativism may limit the contribution of research on thinking to basic psychological science.
ABC of Asthma: ASTHMA IN CHILDREN: TREATMENT
Authors: J. Rees, J. Price
Journal: BMJ (1995)

The aims of treatment should be: * to abolish symptoms and allow children to lead a full and active life at home and at school * to restore normal lung function * to minimise the requirement for relief medication * to enable normal growth and development and avoid adverse effects of medication.These can be achieved by prompt diagnosis, identification of trigger factors, evaluation of severity, establishment of a partnership of management with the asthmatic child and the family, and regular review. Partnership in managementAssessment of management * Frequency of cough/wheeze * Use of relief medication * Days off school/activity * Inhaler technique * Understanding of treatment There has been much discussion recently about "self management" and "self management plans."The term is slightly misleading and a better description is partnership in management.The aim is to develop a strategy for management which will help asthmatic children and their families to cope with the day to day care of their asthma.The strategy should be adapted to the severity of the asthma and to the home and school circumstances.Partnership in management comprises: * understanding asthma and its treatment * monitoring symptoms * if the child is old enough, use of a peak flow meter, * an agreed action plan of what to do if the asthma improves, gets worse or the child has an acute asthma attack * written guidelines.Trained respiratory nurses working in asthma clinics and in schools have a vital role in partnership management.There are also many educational aids available including written material produced by lay organisations such as the National Asthma Campaign, videos, computer programs, and so on.They are valuable supplements to but not substitutes for regular personal contact between families and appropriately trained healthcare professionals. Changing the environmentIrresistible but not desirable in asthmatic families.
Save European research campaign
Authors: B. Moulton
Journal: BMJ (2004)

EDITOR—The Save European Science campaign (http://www.saveeuropeanresearch.org/) was launched on 9 December 2003 out of concern for the future of academic and investigator led research in Europe with the advent of the European Union clinical trials directive (see p 240). It was launched from a cancer platform but is inclusive in spirit and has already gained momentum in cardiology, dermatology, and psychiatry.

The directive was …
Diagnostic Evaluation of Low Back Pain with Emphasis on Imaging
Authors: Jeffrey G. Jarvik, Richard A. Deyo
Journal: Annals of Internal Medicine (2002)

To review evidence on the diagnostic accuracy of clinical information and imaging for patients with low back pain in primary care settings.MEDLINE search (January 1966 to September 2001) for articles and reviews relevant to the accuracy of the clinical and radiographic examination of patients with low back pain.The authors reviewed abstracts and selected articles for review on the basis of a combined judgment. Data on the clinical examination were based primarily on recent systematic reviews; data on imaging tests were based primarily on original articles.Diagnostic results were extracted by one or the other author. Quality of methods was evaluated informally. Major potential biases were identified, but neither quantitative data extraction nor scoring was done.Formal meta-analysis was not used because the diagnostic hardware and software, gold standards, and patient selection methods were heterogeneous and the number of studies was small. Sensitivity for cancer was highest for magnetic resonance imaging (0.83 to 0.93) and radionuclide scanning (0.74 to 0.98); specificity was highest for magnetic resonance imaging (0.9 to 0.97) and radiography (0.95 to 0.99). Magnetic resonance imaging was the most sensitive (0.96) and specific (0.92) test for infection. The sensitivity and specificity of magnetic resonance imaging for herniated discs were slightly higher than those for computed tomography but very similar for the diagnosis of spinal stenosis.The data suggest a diagnostic strategy similar to the 1994 Agency for Health Care Policy and Research guidelines. For adults younger than 50 years of age with no signs or symptoms of systemic disease, symptomatic therapy without imaging is appropriate. For patients 50 years of age and older or those whose findings suggest systemic disease, plain radiography and simple laboratory tests can almost completely rule out underlying systemic diseases. Advanced imaging should be reserved for patients who are considering surgery or those in whom systemic disease is strongly suspected.
Cutaneous focal mucinosis
Authors: S. NISHIURA, M. MIHARA, S. SHIMAO, H. OGAWA, Y. KAWAMURA
Journal: British Journal of Dermatology (1989)

Journal Article Cutaneous focal mucinosis Get access S. NISHIURA, S. NISHIURA Department of Dermatology, Tottori University School of Medicine, Yonago, Japan Dr S. Nishiura, Department of Dermatology, Tottori University School of Medicine, 36‐1 Nishimachi, 683, Japan Search for other works by this author on: Oxford Academic Google Scholar M. MIHARA, M. MIHARA Department of Dermatology, Tottori University School of Medicine, Yonago, Japan Search for other works by this author on: Oxford Academic Google Scholar S. SHIMAO, S. SHIMAO Department of Dermatology, Tottori University School of Medicine, Yonago, Japan Search for other works by this author on: Oxford Academic Google Scholar H. OGAWA, H. OGAWA Division of Surgery, Hirose Hospital, Shimane, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. KAWAMURA Y. KAWAMURA Division of Surgery, Hirose Hospital, Shimane, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue 4, 1 October 1989, Pages 511–515, https://doi.org/10.1111/j.1365-2133.1989.tb15521.x Published: 01 October 1989
Variation in the Region of the Angiotensin-Converting Enzyme Gene Influences Interindividual Differences in Blood Pressure Levels in Young White Males
Authors: Myriam Fornage, Christopher I. Amos, Sharon Kardia, Charles F. Sing, Stephen T. Turner, Eric Boerwinkle
Journal: Circulation (1998)

Background —The renin-angiotensin system regulates blood pressure through its effects on vascular tone, renal hemodynamics, and renal sodium and fluid balance. Methods and Results —Using data from a large population-based sample of 1488 siblings having a mean age of 14.8 years and belonging to the youngest generation of 583 randomly ascertained three-generation pedigrees from Rochester, Minn, we carried out variance components–based linkage analyses to evaluate the contribution of variation in four renin-angiotensin system gene regions (angiotensinogen, renin, angiotensin I–converting enzyme, and angiotensin II receptor type 1) to interindividual variation in systolic, diastolic, and mean arterial pressure. We rejected the null hypothesis that allelic variation in the region of the angiotensin-converting enzyme ( ACE ) gene does not contribute to interindividual blood pressure variability. After conditioning on measured covariates, variation in this region accounted for 0%, 13% ( P =0.04), and 16% ( P =0.04) of the interindividual variance in systolic, diastolic, and mean arterial pressures, respectively. These estimates were even greater in a subset of subjects with a positive family history of hypertension (0%, 29% [ P =0.005], and 32% [ P &lt;0.005], respectively). In sex-specific analyses, genetic variation in the region of the ACE gene significantly influenced interindividual blood pressure variation in males (37% for SBP [ P =0.03], 38% for DBP [ P =0.04], and 53% for MAP [ P &lt;0.005]) but not in females. Conclusions —Although it is possible that variation in a gene near the ACE gene may explain the observed results, knowledge about the physiological involvement of ACE in blood pressure regulation supports the proposition that the ACE gene itself influences blood pressure variability in a sex-specific manner.
The Rate of Iron Accumulation in Hemochromatosis.
Authors: W. H. Crosby
Journal: Annals of Internal Medicine (1963)

s1 April 1963The Rate of Iron Accumulation in Hemochromatosis.W. H. Crosby, M.D., F.A.C.P., M. Conrad Jr., MC (Associate), M. S. Wheby, MCW. H. Crosby, M.D., F.A.C.P., M. Conrad Jr., MC (Associate), M. S. Wheby, MCAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-731_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBy means of repeated phlebotomy to recover and measure the accumulated iron and by determining the rate of replenishment of hemoglobin after induced iron deficiency, it is possible to compute the rate at which iron is accumulated by absorption from the diet. Normal humans are presumed to be in iron balance and absorb iron only to replace what is lost; they accumulate none. During recovery from induced iron deficiency, a normal human accumulated iron at the rate of about 6 mg/day. Patients with hemochromatosis were found to accumulate iron at the rate of 3 to 5 mg/day. With iron deficiency,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 731-731KeywordsDietHemochromatosisHemoglobinIron deficiencyPhlebotomy Issue Published: 1 April 1963 PDF downloadLoading ...
Dutch pharmacists revamp their image
Authors: R Pascoe
Journal: BMJ (1994)

The Dutch pharmacists' organisation has launched a 17 million guilder (pounds sterling 6.2m) campaign to increase the profession's profile and emphasise its role in the health care system. The three year campaign aims at encouraging people to turn to dispensing chemists for advice about medicines. Backed by a series of television advertisements about medicines and their use, the campaign aims at dispelling the image of the pharmacist as a well paid glorified shop assistant. According to the association's research, half the …
Acquired von willebrand's disease: A rare manifestation of postpartum thyroiditis
Authors: Cheryl A. Aylesworth, Robert C. Smallridge, Margaret E. Rick, Barbara M. Alving
Journal: American Journal of Hematology (1995)

Abstract This report describes the diagnosis of acquired type I von Willebrand disease in a 30‐year‐old woman (G 5 P 5 ) who presented with complaints of excessive bleeding in the postpartum period. The patient's additional complaints of fatigue, depression, and inability to lose weight resulted in laboratory testing that indicated hypothyroidism due to thyroiditis. Clinical symptoms and laboratory tests for von Willebrand disease and hypothyroidism normalized with L‐thyroxine replacement Thyroiditis resulting in symptomatic hypothyroidism occurs in 2–4 per cent of postpartum women. The possibility of underlying hypothyroidism should be considered for those patients, especially if they are parous women, who appear to have an acquired bleeding disorder suggestive of von Willebrand disease.
SPONDYLITIS FOLLOWING CEREBROSPINAL MENINGITIS
Authors: R. WALLACE BILLINGTON
Journal: JAMA (1924)

This paper is based on a study of thirty-five cases in which there was the complaint of persistent back symptoms dating from attacks of acute meningitis. Thirty-three of these patients were ex-service men whose trouble began during the World War, and who came under my observation during the last five years while I was acting as consultant to our local unit of the Veterans' Bureau. The other two were seen while I was in civil practice, one a boy, aged 12, who had had meningitis five years before, and the other a man of 32, the onset of whose trouble dated back fifteen years; both had had pain and stiffness in the lumbar spine ever since. These two patients were seen by courtesy of Drs. Jack Witherspoon and W. C. Dixon. In a paper on "Low Back Pain" read before the Southern Medical Association in November, 1922, I<sup>1</sup>referred
Multicenter Validation of a Risk Index for Mortality, Intensive Care Unit Stay, and Overall Hospital Length of Stay After Cardiac Surgery
Authors: Jack V. Tu, Susan B. Jaglal, C. David Naylor
Journal: Circulation (1995)

Background A multicenter population-based study was conducted to develop and validate a risk index for mortality, intensive care unit (ICU) length of stay, and postoperative length of stay after cardiac surgery. Methods and Results Data were collected from 13 098 patients undergoing cardiac surgery between April 1, 1991, and March 31, 1993, at all nine adult cardiac surgery institutions in Ontario, Canada. A six-variable risk index (age, sex, left ventricular function, type of surgery, urgency of surgery, and repeat operation) was developed using logistic regression analysis to predict in-hospital mortality, ICU stay in days, and postoperative stay in days after cardiac surgery in a derivation set of 6213 patients who had cardiac surgery during fiscal year 1991 (April 1, 1991, to March 31, 1992). The index predicted mortality, prolonged ICU stay (≥6 days), and prolonged postoperative length of stay (≥17 days) after cardiac surgery with areas under the receiver-operating characteristic (ROC) curve of 0.75, 0.66, and 0.69, respectively, in an independent validation set of 6885 patients who had cardiac surgery during fiscal year 1992 (April 1, 1992, to March 31, 1993). Increasing risk scores were associated with greater mortality rates and longer ICU and postoperative stays at all nine institutions. Conclusions Mortality, ICU length of stay, and postoperative length of stay after cardiac surgery can be predicted using a simple six-variable risk index. The index has potential application as a risk stratification tool for comparing patient outcomes and resource use among different hospitals and surgeons.