tbuckley/cabot-search huggingface dataset:
Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR
Authors: Vincent W. Keng, Daniela Sia, Aaron L. Sarver, Barbara R. Tschida, Danhua Fan, Clara Alsinet, Manel Solé, Wai L. Lee, Timothy P. Kuka, Branden S. Moriarity, Augusto Villanueva, Adam J. Dupuy, Jesse D. Riordan, Jason B. Bell, Kevin A.T. Silverstein, Josep M. Llovet, David A. Largaespada
Journal: Hepatology (2012)

Abstract Hepatocellular carcinoma (HCC) is one of the deadliest solid cancers and is the third leading cause of cancer-related death. There is a universal estimated male/female ratio of 2.5, but the reason for this is not well understood. The Sleeping Beauty ( SB ) transposon system was used to elucidate candidate oncogenic drivers of HCC in a forward genetics screening approach. Sex bias occurrence was conserved in our model, with male experimental mice developing liver tumors at reduced latency and higher tumor penetrance. In parallel, we explored sex differences regarding genomic aberrations in 235 HCC patients. Liver cancer candidate genes were identified from both sexes and genotypes. Interestingly, transposon insertions in the epidermal growth factor receptor ( Egfr ) gene were common in SB -induced liver tumors from male mice (10/10, 100%) but infrequent in female mice (2/9, 22%). Human single-nucleotide polymorphism data confirmed that polysomy of chromosome 7, locus of EGFR , was more frequent in males (26/62, 41%) than females (2/27, 7%) ( P = 0.001). Gene expression–based Poly7 subclass patients were predominantly male (9/9) compared with 67% males (55/82) in other HCC subclasses ( P = 0.02), and this subclass was accompanied by EGFR overexpression ( P &lt; 0.001). Conclusion : Sex bias occurrence of HCC associated with EGFR was confirmed in experimental animals using the SB transposon system in a reverse genetic approach. This study provides evidence for the role of EGFR in sex bias occurrences of liver cancer and as the driver mutational gene in the Poly7 molecular subclass of human HCC. (Hepatology 2013)
Principles of Surgical Technique: The Art of Surgery
Authors: David C. Brewster
Journal: JAMA (1983)

As most surgeons would agree, the acquisition of surgical skills is a subtle process based largely on actual performance of the manual tasks in the operating room itself. Good surgical technique is, however, based on certain general principles and fundamentals. While difficult to teach and communicate, particularly in written form, appreciation and understanding of basic concepts relating to asepsis, tissue handling, hemostasis, and exposure should contribute to the mastery of surgical technique. It is the authors' purpose to bridge the gap between "knowing" and "doing" by presentation of a logical and unified set of basic principles of technique not found in either standard surgical textbooks or surgical atlases. Throughout this book, they stress to new surgeons the overriding principle of "do no harm." The book is divided into two parts; the first outlines broad fundamental principles and includes a brief historical perspective and concise description of the key aspects of
Safety and efficacy of an accelerated streptokinase regimen in combination with enoxaparin in the prehospital management of the ST acute myocardial infarction (ASENOX-2) study
Authors: Gabriel Tatu-Chitoiu, Mircea Oprisan, Ovidiu Cismara, Rodica Marinescu, Adela Marinescu, Radu Turcu, Maria Dorobantu
Journal: Journal of the American College of Cardiology (2003)
Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome
Authors: Elena V. Semina, Rebecca Reiter, Nancy J. Leysens, W. Lee M. Alward, Kent W. Small, Nicole A. Datson, Jacqueline Siegel-Bartelt, Diane Bierke-Nelson, Pierre Bitoun, Bernhard U. Zabel, John C. Carey, Jeffrey C. Murray
Journal: Nature Genetics (1996)
3′-UTR and Functional Secretor Haplotypes in Mannose-Binding Lectin 2 Are Associated with Increased Colon Cancer Risk in African Americans
Authors: Krista A. Zanetti, Majda Haznadar, Judith A. Welsh, Ana I. Robles, Bríd M. Ryan, Andrew C. McClary, Elise D. Bowman, Julie E. Goodman, Toralf Bernig, Stephen J. Chanock, Curtis C. Harris
Journal: Cancer Research (2012)

Abstract Because chronic intestinal inflammation is a risk factor for colorectal cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer susceptibility. Here, we report the association of 24 MBL2 single-nucleotide polymorphisms (SNP) and corresponding haplotypes with colon cancer risk in a case–control study. Four SNPs in the 3′-untranslated region (UTR) of the gene (rs10082466, rs2120132, rs2099902, and rs10450310) were associated with an increased risk of colon cancer in African Americans. ORs for homozygous variants versus wild-type ranged from 3.17 [95% confidence interval (CI), 1.57–6.40] to 4.51 (95% CI, 1.94–10.50), whereas the 3′-UTR region haplotype consisting of these four variants had an OR of 2.10 (95% CI, 1.42–3.12). The C allele of rs10082466 exhibited a binding affinity of miR-27a and this allele was associated with both lower MBL plasma levels and activity. We found that 5′ secretor haplotypes known to correlate with moderate and low MBL serum levels exhibited associations with increased risk of colon cancer in African Americans, specifically as driven by two haplotypes, LYPA and LYQC, relative to the referent HYPA haplotype (LYPA: OR, 2.60; 95% CI, 1.33–5.08 and LYQC: OR, 2.28; 95% CI, 1.20–4.30). Similar associations were not observed in Caucasians. Together, our results support the hypothesis that genetic variations in MBL2 increase colon cancer susceptibility in African Americans. Cancer Res; 72(6); 1467–77. ©2012 AACR.
THE RELATION OF STREPTOCOCCI TO HERPES VIRUS ENCEPHALITIS
Authors: Peter K. Olitsky, Perrin H. Long
Journal: The Journal of Experimental Medicine (1928)

Cultures of microorganisms similar to those described by Evans have been obtained in media inoculated with suspensions of herpes virus-infected brains prepared by grinding. But they have also been isolated from saline suspensions of uninoculated meat particles ground in a sterile mortar, and from dextrose broth treated in the same way. It is believed that these organisms are contaminants introduced during the process of grinding. Since they enter the material in no great number, one may suppose them to be suppressed by animals inoculated with the ground substance. In artificial media, on the other hand, they find favorable conditions for multiplication. In our experience, no growth of microorganisms is obtained in routine cultures of virus-infected brains, when fragments, instead of ground material, are used-a fact which may be taken to support the explanation just given. The tests of the part played by streptococci in experimental virus encephalitis failed to disclose that the microorganisms have any etiological relationship to the affection. The intracerebral injection of rabbits with the cultures procured in the course of the experiments produces a purulent type of meningoencephalitis which does not resemble virus encephalitis either in its symptom-complex or in its pathology. The same type of meningitis follows the injection of streptococci derived from ground meat particles, from "ground" broth, from normal brains, and those infected with herpes virus. Some rabbits manifested resistance to the streptococci, whereas all that have been inoculated intracerebrally with the three strains of herpes virus used in this study have proved susceptible thereto. Certain of the rabbits just mentioned which had proved resistant to streptococci inoculated into the brain or cornea were injected with herpes virus and reacted typically. Comparative tests have revealed that the streptococci are more sensitive to the destructive effect of 50 per cent glycerol than is herpes virus. From all this, it can be concluded that streptococci are not the visible form of herpes virus, nor do they produce in rabbits effects like those induced in the brain and cornea by the herpes virus.
T-cell receptor repertoire in pyoderma gangrenosum: evidence for clonal expansions and trafficking
Authors: T.N. Brooklyn, A.M. Williams, M.G.S. Dunnill, C.S. Probert
Journal: British Journal of Dermatology (2007)

Journal Article T‐cell receptor repertoire in pyoderma gangrenosum: evidence for clonal expansions and trafficking Get access T.N. Brooklyn, T.N. Brooklyn Clinical Science at South Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol, BS2 8HW, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.M. Williams, A.M. Williams Clinical Science at South Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol, BS2 8HW, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.G.S. Dunnill, M.G.S. Dunnill Clinical Science at South Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol, BS2 8HW, U.K. Search for other works by this author on: Oxford Academic Google Scholar C.S. Probert C.S. Probert Clinical Science at South Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol, BS2 8HW, U.K. Correspondence: C.S. Probert. E‐mail: c.s.j.probert@bristol.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 5, 1 November 2007, Pages 960–966, https://doi.org/10.1111/j.1365-2133.2007.08211.x Published: 01 November 2007
Case 1-1973
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Herbert L. Abrams, Stanley J. Robboy
Journal: New England Journal of Medicine (1973)

Presentation of CaseA 67-year-old man was admitted to the hospital because of abdominal pain.He had been in excellent health until three months before admission, when there was the gradual onset of intermittent crampy periumbilical pain that was accompanied by anorexia, aggravated by eating and relieved by fasting. A barium-enema examination and two upper gastrointestinal studies, performed at another hospital, were reported to be negative. During the next two months the symptoms increased in severity, with loss of 15 kg in weight. Six weeks before entry he became constipated, and subsequently diarrhea occurred for several days, with exacerbation of . . .
INCIDENCE AND COSTS OF ACUTE RESPIRATORY DISEASE IN INDUSTRY
Authors: A. J. LANZA
Journal: JAMA (1941)

The common cold has been the subject of intensive study for a number of years. In 1923 Frost and his co-workers in the United States Public Health Service commenced a study of the incidence of colds that extended over ten years, and numerous statistical studies emanated from the Public Health Service, prepared by Brundage, Britten and others. All these studies showed a fair degree of unanimity, allowance being made for the fact that the term "common cold" is descriptive rather than scientifically accurate. It is difficult, if not impossible, at times to determine when a cold is not a cold, and the term itself, in the popular usage, is mingled with other terms, such as grip, influenza, nasal infection, cough and sinus trouble so as to constitute a statistical headache for any one who strives to be accurate. In recent years attention has been focused on sick absenteeism among industrial
Points: Treating the discharging ear
Authors: N. B Solomons, G. J Madden
Journal: BMJ (1988)

Out of 233 patients admitted for head trauma during 1977-1978, 93 had a CT scan examination within the first 48 hours. Forty-nine of these had at least one clinical risk factor for post-traumatic epilepsy. Ten of this group developed post-traumatic epilepsy. In all cases early CT scan showed focal brain damage, which was related more significantly to post-traumatic epilepsy than to risk factors.
I. PROLONGED INTUBATION. II. ESOPHAGOTOMY FOR A DENTAL PLATE. III. LARYNGECTOMY FOR CARCINOMA.
Authors: GEORGE F. COTT
Journal: JAMA (1903)

<h3>I.—A CASE OF PROLONGED INTUBATION.</h3> One of the rarest accidents following intubation for diphtheria is stenosis, which results from pressure ulceration of the subglottic region and is very difficult to remedy. There are, perhaps, half a dozen cases on record; several made complete recoveries. One of these is as follows: <h3>Intubation.</h3> —Rosa McGlynn, aged 6, was taken sick with diphtheria in December, 1901, and in a very few days required intubation. Being otherwise engaged, I sent my assistant, Dr. James E. King, to perform the operation. A week later the tube was removed, but had to be replaced immediately. Several days thereafter I removed the tube, but within a very few minutes had to replace it. This occurred frequently for several weeks. In order to keep better watch of the child I had her removed to the Riverside Hospital, and there the tube was removed and replaced off and on for
NFκB-mediated upregulation of bcl-xl restrains TRAIL-mediated apoptosis in murine viral hepatitis
Authors: Lars Zender, Sebastian Hütker, Bettina Mundt, Morlen Waltemathe, Christian Klein, Christian Trautwein, Nisar P. Malek, Michael Peter Manns, Florian Kühnel, Stefan Kubicka
Journal: Hepatology (2005)

Inhibition of NFkappaB enhances the susceptibility of cancer to TRAIL-mediated apoptosis and is suggested as a strategy for cancer therapy. Because the role of NFkappaB in TRAIL-mediated apoptosis of hepatocytes is unknown, we investigated the influence of NFkappaB-inhibition in death ligand-mediated apoptosis in hepatitis. Adenoviral hepatitis resulted in upregulation of NFkappaB-activity, which could be inhibited by expression of IkappaBalpha-superrepressor. We treated mice after the onset of adenoviral hepatitis with adenoviruses expressing FasL (AdFasL), TRAIL (AdTRAIL), or GFP (AdGFP). In contrast to apoptosis induced by AdFasL, NFkappaB inhibition strongly enhanced AdTRAIL-mediated apoptosis of hepatocytes. Expression of IkappaBalpha inhibits adenoviral infection-mediated overexpression of bcl-xl, providing a molecular mechanism for TRAIL sensitization. In agreement with this hypothesis, downregulation of bcl-xl by siRNA enhanced susceptibility of hepatocytes to TRAIL, but not to FasL-mediated apoptosis, resulting in TRAIL-mediated severe liver damage after AdTRAIL application. Our data demonstrate that inhibition of NFkappaB in adenoviral hepatitis strongly sensitizes hepatocytes to TRAIL-mediated apoptosis. Bcl-xl, in contrast to bcl-2 and c-FLIP, is strongly upregulated after viral infection and represents an essential NFkappaB-dependent survival factor against TRAIL-mediated apoptosis. In conclusion, inhibition of NFkappaB or bcl-xl during TRAIL therapy may harbor a risk of liver damage in patients with viral hepatitis.
Maternal Thyroxine and Congenital Hypothyroidism
Authors: P. Reed Larsen
Journal: New England Journal of Medicine (1989)

THE syndrome of cretinism, the irreversible mental retardation that occurs in infants with untreated hypothyroidism, is the best evidence that thyroid hormone is required for normal human development. Nonetheless, most newborn infants with congenital hypothyroidism are asymptomatic and must be identified by biochemical screening. Furthermore, the great majority of the infants treated after having been identified by such screening programs have normal intellectual development. How can the apparent normality of hypothyroid infants at birth be reconciled with their profound abnormality if not treated very soon after birth? The report of Vulsma et al. in this issue of the Journal demonstrates . . .
"One Tablet Per Day" for Osteoporosis: Hypercalcemia
Authors: LESLIE S. LIBOW
Journal: Annals of Internal Medicine (1974)

Letters1 July 1974"One Tablet Per Day" for Osteoporosis: HypercalcemiaLESLIE S. LIBOW, M.D., F.A.C.P., FRANK ROSS, M.D., KENNETH GOLDBERG, M.D.LESLIE S. LIBOW, M.D., F.A.C.P.Search for more papers by this author, FRANK ROSS, M.D.Search for more papers by this author, KENNETH GOLDBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-120_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We recently encountered two cases of elderly patients with hypercalcemia secondary to "one tablet per day" of vitamin D administration. The vitamin D (calciferol) was given for osteoporosis of the lumbar spine accompanied by pain and vertebral collapse. In one case, 50 000 units (one tablet) per day of vitamin D was given with daily administration of calcium gluconate, 600 mg, fluoxymesterone (Halotestin®*) and chlorothiazide, for a total of 4½ months. In the other, 50 000 units per day of vitamin D was given for 1 year, without supplemental calcium or any other medication. Both patients were...References1. AVIOLIMCDONALDLEE LSS: The influence of age on the intestinal absorption of 47Ca in women and its relation to 47Ca absorption in postmenopausal osteoporosis. J Clin Invest 44:1960-1967, 1965 CrossrefMedlineGoogle Scholar2. BULLAMOREWILKINSONGALLAGHER JRJ: Effect of age on calcium absorption. Lancet 2:535-537, 1970 CrossrefMedlineGoogle Scholar3. URIST M: Orthopaedic management of osteoporosis in post-menopausal women. Clin Endocrinol Metab: Osteoporosis 2:159-176, 1973 CrossrefMedlineGoogle Scholar4. GALLAGHERAARONHORSMAN JJA: The crush fracture syndrome in post-menopausal women. Ibid., 293-315 Google Scholar5. WEISS W: Fat soluble vitamins; vitamin D, in The Pharmacological Basis of Therapeutics, edited by GOODMAN LS, GILLMAN A. New York, The MacMillan Co., 1970, p. 168 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Divisions of Geriatrics and Endocrinology Department of Medicine Mount Sinai Hospital Services City Hospital Center and The Mount Sinai School of Medicine of the City University of New York Elmhurst, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1974Volume 81, Issue 1Page: 120-121KeywordsCalciumElderlyFluoxymesteroneHypercalcemiaOsteoporosisSpineVitamin D Issue Published: 1 July 1974 PDF downloadLoading ...
Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis
Authors: Anna M. Eiring, Paolo Neviani, Ramasamy Santhanam, Joshua J. Oaks, Ji Suk Chang, Mario Notari, William Willis, Carlo Gambacorti-Passerini, Stefano Volinia, Guido Marcucci, Michael A. Caligiuri, Gustavo W. Leone, Danilo Perrotti
Journal: Blood (2007)
LAD WRAPPING AROUND THE LV APEX PREDICTS ADVERSE CARDIAC OUTCOMES IN ANTERIOR STEMI- A HORIZONS-AMI SUB-STUDY
Authors: Nobuaki Kobayashi, Akiko Maehara, Sorin Brener, Philippe Genereux, Bernhard Witzenbichler, Giulio Guagliumi, Jan Peruga, Ke Xu, Roxana Mehran, Gary Mintz, Gregg Stone
Journal: Journal of the American College of Cardiology (2014)
Pentoxifylline and Vitamin E Treatment for Prevention of Radiation Induced Side Effects in Women with Breast Cancer: A Phase Two, Double Blind, Placebo Controlled Randomised Clinical Trial (Ptx-5).
Authors: P. Malmström
Journal: Cancer Research (2009)

Abstract Background: A previous study has shown that pentoxifylline in combination with vitamin E can reverse radiation induced fibrosis. Our aim in the present study was to investigate if the same drugs could prevent radiation induced side effects in women with breast cancer.Patients and Methods: A randomised, placebo-controlled, double blind, parallel group trial was performed. Women with breast cancer were treated for 12 months with pentoxifylline 400 mg t.i.d. or placebo, in combination with vitamin E 100 mg t.i.d. starting 1-3 months after the completion of radiotherapy. The primary endpoint was passive abduction of the shoulder, and the secondary endpoint was difference in arm volumes. The trial is registered on the ISRCTN.org website, number ISRCTN39143623.Results: 83 patients were included in the study; 42 in the pentoxifylline + vitamine E group and 41 in the placebo + vitamine E group. Both treatments were generally well tolerated. Seven patients were withdrawn from treatment due to disease progression; four in the pentoxifylline group and three in the placebo group. At inclusion patients had impaired passive abduction of the shoulder. During treatment both groups improved significantly. With one year of follow-up median improvement from baseline was 3.7° (p=0.0035) in the pentoxifylline group and 9.4° (p= 0.0041) in the placebo group, but no difference between the groups was detected (p=0.20). Arm volumes increased over time in the placebo group (1.04%), but not in the pentoxifylline group (0.50%). This difference between the groups was statistically significantl(p=0.0172).Conclusions: The combination of pentoxifylline and vitamin E was safe and may be used for prevention of some radiation induced side effects. We found that pentoxifylline in combination with vitamin E diminished development of lymphoedema.(Accepted for publication in European Journal of Cancer)Updated results with longer follow-up will be presented. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 4100.
Sympathetic Activity in Essential Hypertension
Authors: Jan Koch-Weser
Journal: New England Journal of Medicine (1973)

Does excessive activity of the sympathetic nervous system (SNS) contribute to the development and persistence of abnormal arterial pressure in patients with primary hypertension? Many investigators have tried to answer this question during the last four decades, but, because of conceptual and methodologic problems, no firm conclusions have been reached.1 , 2 "Overactivity" of the SNS in hypertension is a problematical concept. In normotensive persons, the intensity of sympathetic stimulation of the heart and blood vessels varies greatly with posture, activity, emotional state, physical conditioning and cardiovascular health. It influences venous capacitance, heart rate, myocardial contractility, as well as cardiac output and . . .
Effects of Cholesterol-Fat Diets on Pigeons Susceptible and Resistant to Atherosclerosis
Authors: THOMAS B. CLARKSON, HUGH B. LOFLAND
Journal: Circulation Research (1961)

Cholesterol-fat diets are markedly more atherogenic when fed to a strain of pigeons susceptible to spontaneous atherosclerosis, as compared to a strain resistant to the disease. A breed of pigeons intermediate in susceptibility was found to be intermediate in their response to a high cholesterol-high fat diet. Serum cholesterol levels were similar among the three breeds. The White Carneau pigeons developed lesions complicated by connective tissue proliferation while the Autosexing Kings and Racing Homers developed merely "pure atheroma" or "fatty streaks."
Long-term quality of life after liver donation in the adult to adult living donor liver transplantation cohort study (A2ALL)
Authors: Daniela P. Ladner, Mary Amanda Dew, Sarah Forney, Brenda W. Gillespie, Robert S. Brown, Robert M. Merion, Chris E. Freise, Paul H. Hayashi, Johnny C. Hong, April Ashworth, Carl L. Berg, James R. Burton, Abraham Shaked, Zeeshan Butt
Journal: Journal of Hepatology (2014)
Multilayered, core/shell nanoprobes based on magnetic ferric oxide particles and quantum dots for multimodality imaging of breast cancer tumors
Authors: Qiang Ma, Yuko Nakane, Yuki Mori, Miyuki Hasegawa, Yoshichika Yoshioka, Tomonobu M. Watanabe, Kohsuke Gonda, Noriaki Ohuchi, Takashi Jin
Journal: Biomaterials (2012)