tbuckley/cabot-search huggingface dataset:
Danazol for Henoch-Schonlein Purpura
Authors: Young J. Lee
Journal: Annals of Internal Medicine (1993)

Letters15 May 1993Danazol for Henoch-Schonlein PurpuraYoung J. Lee, MD, Lawrence L. Horstman, MD, and Yeon S. Ahn, MDYoung J. Lee, MDSearch for more papers by this author, Lawrence L. Horstman, MDSearch for more papers by this author, and Yeon S. Ahn, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-10-199305150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Henoch-Schonlein purpura is a form of generalized hypersensitivity vasculitis involving the skin, joints, kidneys, and gastrointestinal tract. Corticosteroids have been the mainstay of therapy [1]. We report the successful use of danazol in a young man with classic recurring Henoch-Schonlein purpura refractory to low-dose prednisone therapy [2].A 22-year old white man in good health developed an upper respiratory infection in November 1988. A few days later, palpable small spots appeared over both malleoli and quickly spread to lower extremities and genitals. There were associated myalgias, arthralgias, and swelling of wrist and ankle joints, followed by lower ...References1. Gotlieb A. Allergic purpura. In: William W, ed. Hematology. Fourth edition. New York: McGraw-Hill; 1990:1443. Google Scholar2. Lee Y, Harrington T, Ahn YS. Danazol: a new therapeutic option for Henoch-Schonlein Purpura. Clin Res. 1991; 39:461A. Google Scholar3. Tomino Y, Sakai H, Hanzawa S, Ohno J, Kitajima T, Sakai O. Clinical effect of danazol in patients with IgA nephropathy. Jpn J Med. 1987; 26:162-6. Google Scholar4. Ahn YS. Efficacy of danazol in hematologic disorders. Acta Haematol. 1990; 84:122-9. Google Scholar5. Madanes AE, Farber M. Danazol. Ann Intern Med. 1982; 96:625-30. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDanazol – możliwości wykorzystania w leczeniu chorób hematologicznychDanazol induces prolonged survival of fully allogeneic cardiac grafts and maintains the generation of regulatory CD4+ cells in miceChapter 24 Danazol TherapyApport de la tomodensitométrie abdominopelvienne dans le purpura rhumatoïde de l’adulteSch??nlein-Henoch Purpura in Children and AdultsAngeborene und erworbene vaskuläre hämorrhagische DiathesenPurpura rhumatoïde de l'adulte. À propos de 40 observationsIgA multiple myeloma presenting as Henoch-Schönlein purpura/polyarteritis nodosa overlap syndromeAngeborene und erworbene vaskuläre hämorrhagische Diathesen 15 May 1993Volume 118, Issue 10Page: 827KeywordsInflammationKidneysMyalgiaNauseaProteinuriaRed blood cellsUpper respiratory tract infectionsVasculitisVomitingWeight gain Issue Published: 15 May 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Lymphoscintigraphic Studies of Lymphatic Drainage from the Testes
Authors: SAMUEL D. J. YEH, MICHAEL J. MORSE, ROBERT GRANDO, EDWARD L. KLEINERT, WILLET F. WHITMORE
Journal: Clinical Nuclear Medicine (1986)

Two colloidal radiopharmaceuticals, Au-198 and Tc-99m antimony, were used to evaluate the lymphatic drainage of the testis in experimental animals and humans. One to 24 hours after direct intratesticular injection of Au-198 colloid in dogs and 4-6 hours after injection of Tc-99m antimony colloid in men, distribution within retroperitoneal lymph nodes was demonstrated. Uptake within the para-aortic lymph nodes primarily draining the testis was decreased following proximal ligation of the spermatic vessels in dogs. Testicular lymphoscintigraphy successfully demonstrated an intact spermatic cord lymphatic communication to the para-aortic nodes in five of six patients with chronic lower-extremity lymphedema. When the intact testicle and spermatic cord were transposed to the thigh in a patient with chronic lymphedema of the lower extremity, percutaneous pedal lymphoscintigraphy successfully demonstrated uptake within the para-aortic lymph nodes draining the ipsilateral testis.
Deficiency of Rap1-Binding Protein RAPL Causes Lymphoproliferative Disorders through Mislocalization of p27kip1
Authors: Koko Katagiri, Yoshihiro Ueda, Takashi Tomiyama, Kaneki Yasuda, Yoshinobu Toda, Susumu Ikehara, Keiichi I. Nakayama, Tatsuo Kinashi
Journal: Immunity (2010)
Rupture of Jejunal Varices Treated by Percutaneous Transhepatic Obliteration and Endoscopic Injection Sclerotherapy with N-Butyl-2-Cyanoacrylate
Authors: T. Akahoshi, K. Tanoue, M. Tomikawa, M. Hashizume, K. Sugimachi
Journal: Endoscopy (2001)

Intestinal variceal bleeding in cirrhotic patients is a life-threatening event. We report here on a case of bleeding intestinal varices which was successfully treated nonsurgically.
Symposium on gastrooesophageal reflux and its complications. 1. Definitions, the antireflux mechanism, and symptoms.
Authors: D A Edwards
Journal: Gut (1973)

Symposium on gastrooesophageal reflux and its complications'The symposium aims to present new concepts and provide a plausible working hypothesis as a basis for diagnostic and management decisions.Section 1 Definitions, the antireflux mechanism, and symptoms
THE FATE OF INJECTED BENCE JONES PROTEIN
Authors: Franz Meyer, Frank W. Putnam
Journal: The Journal of Experimental Medicine (1963)

Bence Jones protein injected into rabbits was excreted rapidly into the urine. The excreted protein retained the physicochemical and immunochemical properties of the injected Bence Jones protein. In spite of the rapid excretion, a significant portion of the injected Bence Jones protein was found to be metabolized. After reinjection of radioactive Bence Jones protein into the donor patient, only a little radioactivity was recovered in the urinary protein. The implications of these results are discussed.
Splinter Haemorrhages in Psoriasis.
Authors: L. J. A. Loewenthal.
Journal: British Journal of Dermatology (1964)

Journal Article Splinter Haemorrhages in Psoriasis. Get access L. J. A. Loewenthal. L. J. A. Loewenthal. Johannesburg Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 5, 1 May 1964, Page 235, https://doi.org/10.1111/j.1365-2133.1964.tb14520.x Published: 01 May 1964
FIBRILLATION OF THE AURICLES: ITS EFFECTS UPON THE CIRCULATION
Authors: Thomas Lewis
Journal: The Journal of Experimental Medicine (1912)

When the auricles fibrillate, the following effects are observed. 1. The arterial blood pressure may rise, fall, or remain stationary. Usually it falls. If it falls, it generally rises again towards or to the initial pressure. 2. The venous pressure changes are the reverse of the arterial. 3. The intestinal volume and the cardiac output changes are in the same direction as those of arterial blood pressure. 4. From these observations it may be concluded that the peripheral circulatory effects are purely passive. 5. The volume of the heart decreases except in instances where there is reason to believe that the circulation is failing. All the changes described in the foregoing paragraphs, and also the variations in blood pressure reactions which occur from time to time, are attributable to alterations in the rate of ventricular contraction. Similar, though perhaps less profound changes, are seen when the heart rate accelerates in like degree in response to regular induction shocks.
More About: B-Cell Non-Hodgkin's Lymphoma: Evidence for the t(14;18) Translocation in All Hematopoietic Cell Lineages
Authors: J. Apostolidis, D. M. Lillington, L. K. Goff, E. L. Jones, T. A. Lister, R. K. Gupta
Journal: JNCI Journal of the National Cancer Institute (1999)
Wrinkles and Smoking
Authors: ANTHONY L. BARNERT
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 April 1972Wrinkles and SmokingANTHONY L. BARNERT, M.D.ANTHONY L. BARNERT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-4-672 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Daniell is to be complimented on his imaginative and methodical study of smokers' wrinkles [Ann Intern Med 75:873-880, 1971], but I am compelled to point out a logical flaw in his closing sentence. He there implies that the association between smoking and wrinkling might serve as ammunition in counseling patients on the "personal risks of cigarette smoking."Despite his reservations on causality in the penultimate paragraph, Dr. Daniell has fallen into thecum hoc, propter hocline of reasoning that is all too common in epidemiologic studies. He implies not only causality but also that avoidance... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1972Volume 76, Issue 4Page: 672-673KeywordsEpidemiologyReasoning Issue Published: 1 April 1972 PDF DownloadLoading ...
Reduction of the surface charge of blood polymorphonuclear cells by rheumatoid sera and heat induced aggregated human IgG (HAGG).
Authors: K A Brown, D McCarthy, J D Perry, D C Dumonde
Journal: Annals of the Rheumatic Diseases (1988)

Cell electrophoresis identifies two main subpopulations of blood polymorphonuclear cells (PMNs), which in terms of the speed of their anodic migration are referred to as the fast and slow population. When blood PMNs from normal healthy subjects were incubated in medium containing 20% RA serum there was a decrease in the percentage of fast cells with a corresponding increase in the slow population that was directly related to the levels of circulating immune complexes present in the sera. Similar results were obtained when using heat induced aggregated human IgG (HAGG) or Candida albicans instead of RA serum. The 'slowing' effect of HAGG, which was transient and time dependent, appeared to be due to its internalisation by the PMNs. These results suggest that in RA the large number of blood PMNs with a low surface charge (i.e., the slow population) may arise as a result of the constant interaction of these cells with circulating immune complexes.
Postimplantation X-ray parameters predict functional catheter problems in peritoneal dialysis
Authors: Bert Bammens, Domien Peeters, Joris Jaekers, Kathleen J. Claes, Pieter Evenepoel, Dirk Kuypers, Björn Meijers, Maarten Naesens, Yves Vanrenterghem, Diethard Monbaliu
Journal: Kidney International (2014)
Predictive value of the variceal pressure response to continued pharmacological therapy in patients with cirrhosis and portal hypertension
Authors: Àngels Escorsell, Josep Maria Bordas, Beatriz Castañeda, Josep Llach, Joan Carles García-Pagán, Joan Rodés, Jaume Bosch
Journal: Hepatology (2000)

Noninvasive measurements of variceal pressure adequately reflect the hemodynamic effects of propranolol on portal hypertension. However, the prognostic value of variceal pressure responses during continued propranolol therapy has not been evaluated, and it is unclear whether this may substitute invasive measurements of portal pressure response. Fifty-five portal hypertensive patients with cirrhosis were studied before and at 4 months of continued propranolol therapy. Variceal pressure was measured using an endoscopic pressure gauge. Portal pressure was evaluated as the hepatic venous pressure gradient (HVPG). Over a 28 ± 11 month follow-up, 16 patients experienced variceal bleeding. Baseline characteristics were similar in bleeders and nonbleeders. At 4 months, reduction in variceal pressure was less marked in bleeders than in nonbleeders (5% ± 20% vs. −15% ± 24%; P = .03). A fall in variceal pressure 20% or greater of baseline was an independent predictor of absence of variceal bleeding; which occurred in 5% of patients with a 20% or greater fall in variceal pressure versus 42% of patients with less than a 20% reduction ( P = .004). The HVPG response had similar independent prognostic value (decrease ≥20%: 6% bleeding; decrease &lt;20%: 45% bleeding; P = .004) but identified different patients. Achieving a 20% decrease in either variceal pressure or HVPG was highly sensitive (85%) and specific (93%) identifying patients not bleeding on follow-up. Endoscopic measurements of variceal pressure response to continued pharmacotherapy provide useful prognostic information on the risk of variceal bleeding. As with HVPG response, a fall in variceal pressure of 20% or greater is associated with a very low risk of variceal bleeding. The combination of both parameters allows almost optimal prognostication.
An Address on THE SOURCE OF MODERN MEDICINE
Authors: A. Macphail
Journal: BMJ (1933)

Gentlemen,-I must trouble you with a date, 1685, the year in which Charles II died.That reign marks the watershed between the mediaeval and the modern world; between the mass and the individual; between authority and experience; between books and experiment.From that summit the spring of modern medicine burst forth.It was in reality a new world.The Royal Society had been founded; the circulation of the blood had been proven; the Cartesian method had been disclosed; the universal law of gravity and the laws of planetary motion had just been announced.Logarithms, electricity, magnetism, chemistry, were words coming into common use.Up to that time, the authority in science was Aristotle; in philosophy, Thomas ; in medicine, Galen.All three had organized and synthesized the existing knowledge of their day.It was a useful task.; but when life is too closely organized it begins to perish.The body of knowledge then becomes a burden, a tradition ; it blinds men's eyes ; it makes them incapable of observation or thought.It enslaves them ; but suddenly, freedom asserts itself.Freedom too has perils, but.they are less dangerous than the perils of slavery.One can now say what he likes, even in medicine, no matter how foolish ; there will be plenty to contradict him.There were reasons deeper still for the scientific renascence of the period under review.The divine right in science of Aristotle and the Greeks had passed ; the divine right of kings in politics perished at the hand of Cromwell ; the divine right of Galen in medicine came to an end with the appearance of Thomas Sydenham ; and so we have come to our subject at last.For a perfect sight of the old medicine, let me conduct you to the bedside of Charles Il: With a cry he fell.Dr. King, who, unfortunately,happened to be present, bled him with-a pocket-knife.Fourteen physicians were quickly in attendance.They bled him more thoroughly they scarified and cupped him; they shaved and blistered his head ; they gave him an emetic, a clyster, and two pills.During the next eight days they " threw in " fiftyseven separate drugs; and, towards the end, a cordial containing forty more.This -availing nothing, they tried Goa stone, which was: a calculus obtained from a species of Indian goat ; and as a -final remedy, the distillate of human skull.In the-case report it is recorded that the emetic and the purge worked so mightily well it was a wonder the patient died-.-Onephysician did protest that they would kill the king-; and out of this arose the sus- picion that he haLd been irregularly poisoned.But he did die, " as peaceable ag a, lamb ; his last words were, "Do not let poor Nellie starve.
Effects of exercise on aortic input impedance and pressure wave forms in normal humans.
Authors: J P Murgo, N Westerhof, J P Giolma, S A Altobelli
Journal: Circulation Research (1981)

The effects of supine bicycle exercise on the input impedance of the ascending aorta were studied in thirteen male subjects undergoing cardiac catheterization, but in whom no cardiovascular disease was found. Ascending aortic flow velocity and pressure were recorded simultaneously from a multisensor catheter with an electromagnetic flow velocity probe and a pressure sensor mounted at the same location. A second pressure sensor at the catheter tip provided left ventricular pressure. Fick cardiac outputs were used to scale the velocity signal to instantaneous volumetric flow. Input impedance was calculated from 10 harmonics of aortic pressure and flow. For each subject, impedance moduli and phases from a minimum of 15 beats during rest and exercise were averaged. Peripheral resistance decreased from a resting value of 1142 +/- 51 (+/- SE) dynes sec/cm5 to 712 +/- 39 dynes sec/cm5 during exercise. Characteristic impedance remained unchanged with a resting value of 47 +/- 4 dynes sec/cm5 and an exercise value of 45 +/- 4 dynes sec/cm5. These results were associated with an increase in aortic pressure (96 +/- 2 to 111 +/- 2 mm Hg) and pulse wave velocity implying a decrease in aortic compliance. An increase in aortic cross-sectional area apparently offsets the effects of these changes in compliance and pulse wave velocity to result in an unchanged characteristic impedance. The increase in pulse wave velocity caused wave reflections to occur earlier during exercise, but the general characteristics of the pressure wave shapes remained unchanged.
Rebuttal: Appraisal of Antihypertensive Drug Therapy
Authors: EDWARD D. FREIS
Journal: Circulation (1974)

has long been known for his skepticism with respect to the treatment of hypertension.Indeed, it was the skep- ticism of Drs.Goldring, Chasis and Perera which served as an important stimulus in planning the Veterans Administration Cooperative Study.Dr. Chasis completely rejects the concept that the cardiovascular damage seen in hypertension is the consequence of the elevated blood pressure.To him the cardiovascular pathology is independent of the blood pressure.It follows, therefore, that anti- hypertensive therapy cannot prevent further car- diovascular damage or complications.I believe this is why Dr. Chasis makes such unusual interpretations of the available data.His main attack is on the results of the Veterans Ad- ministration Cooperative Study.Unfortunately, he begins with an error of fact.With respect to the first report of the Veterans Administration Cooperative Study Group the numbers of patients randomized were 70 in the control group, not 63 as stated by Chasis, and 73 not 68 in the treated group.Dr. Chasis notes correctly that there were 27 patients with severe complications in the control group and only 2 in the treated group.He attempts to explain this difference by the fact that the control patients may have had more severe vascular disease prior to randomization than did the treated group.It should be noted that patients were randomly assigned double-blind to one regimen or the other.Thus, the chance that biased selection of patients could account for the observed 27 to 2 ratio of morbid events must be of the order one in a thousand or higher.To support his contention that randomization did not establish an equal distribution Dr. Chasis notes that the patients in the control group had a high incidence of vascular disease prior to entry.Thus, 5 had preceding cerebral thrombosis, 5 had diabetes mellitus and'22 had an abnormal electrocardiogram.Dr. Chasis neglects to mention, however, that in the treatment group there also was a high incidence of preceding vascular disease as follows: 6 patients with
Neisseria lactamicus Pharyngitis
Authors: Larry S. Fisher
Journal: JAMA (1975)

<h3>To the Editor.—</h3> A 26-year-old man came to Harbor General Hospital with fever, chills, and a sore throat. His temperature was 40 C (104 F) and there was marked pharyngeal and tonsillar inflammation, with a peritonsillar exudate. Pharyngeal culture grew<i>Neisseria lactamicus</i>in pure culture. This organism appears identical to<i>N meningitidis</i>on culture media, and distinction between the two can only be made on serologic or biochemical grounds.<sup>1,2</sup><i>Neisseria lactamicus</i>differs from<i>N meningitidis</i>in that it ferments lactose and produces a β-galactosidase. The carrier rate of<i>N lactamicus</i>in adults is 0% to 2%.2 The importance of distinguishing the different<i>Neisseria</i>species<i>lactamicus, meningitidis</i>, and<i>gonorrhoeae</i>) has obvious epidemiologic and therapeutic importance.
Increasing genomic and epigenomic complexity in the clonal evolution from in situ to manifest t(14;18)-positive follicular lymphoma
Authors: J Schmidt, I Salaverria, A Haake, I Bonzheim, P Adam, S Montes-Moreno, M A Piris, F Fend, R Siebert, L Quintanilla-Martinez
Journal: Leukemia (2013)
Compulsory Premarital Screening for HIV-Reply
Authors: Paul D. Cleary
Journal: JAMA (1988)

In Reply.  — The comments by Mr Daniels and by Drs Allain, Bridgeman, Cummins, Fahs, Schechter, and Franklin primarily concern specific assumptions on which our analyses are based and so we would like to clarify our rationale for making those assumptions.  There have been numerous studies that indicate that certain groups have higher prevalences of HIV infection than do blood donors. As stated in our original article, we used data from blood donors instead of other populations because we think they are most similar, in terms of risk factors, to persons who are about to be married. Army recruits are demographically different from the premarital population and are more likely to be sexually active, homosexual men and drug abusers. 1,2 The study of infection in Massachusetts infants includes all infants born and thus overrepresents women with higher parity and includes unmarried mothers. Only 63% of the first births in 1980
Prospective study of fluctuations of lupus anticoagulant activity and anticardiolipin antibody titre in patients with systemic lupus erythematosus.
Authors: H J Out, M van Vliet, P G de Groot, R H Derksen
Journal: Annals of the Rheumatic Diseases (1992)

Fluctuations of lupus anticoagulant activity and anticardiolipin antibody titres were studied in 53 patients with systemic lupus erythematosus (SLE). The median study time was 26 months with a median number of 12 samples. Lupus anticoagulant was measured by the kaolin clotting time (KCT) and dilute Russell viper venom time (dRVVT) assays; anticardiolipin antibodies were assayed by an enzyme linked immunosorbent assay (ELISA). Normal and increased KCTs or dRVVTs were seen during follow up in 13 and 12 patients, respectively. IgG anticardiolipin antibodies changed from negative to positive or positive to negative in 26 patients and IgM anticardiolipin antibodies in 16 patients. Disease activity and treatment with prednisone could account for these fluctuations in the kaolin clotting time (KCT) in 7 of 13 patients and in the dRVVT in 2 of 12 patients. Whole group analysis showed that the KCT, dRVVT, and IgM anticardiolipin antibodies were not associated with disease activity, in contrast with IgG anticardiolipin antibodies. During treatment with prednisone normal KCT and dRVVT results were obtained more easily than normal anticardiolipin antibody levels. It is recommended that lupus patients should not be classified as antiphospholipid antibody positive or negative on the basis of only one sample.
Speech Disorders, Aphasia, Apraxia, and Agnosia
Authors: George B. Udvarhelyi
Journal: JAMA (1962)

It is a pleasure to read a book by Sir Russell Brain. We have been accustomed to expect clarity of style, precise organization of thought, and masterful economy of words. This small book dealing with a subject of general interest does not disappoint the reader. The author combines his extensive personal experience with an up-to-date integration of recent developments in the field of speech disorders. His objects in writing this booklet are expressed best in the preface. First, he gives a comprehensive account of the subject, discussing theories of the origin of speech and its development in the child, as well as its normal psychophysiology and breakdown in aphasia. He also gives a historical account of thought about aphasia, leading to a description of the symptoms of this and the closely related disorders apraxia and agnosia. The entire book is written as a critical review based on the thesis that