tbuckley/cabot-search huggingface dataset:
Letter: Red skin and Dorbanex.
Authors: M H Bunney, I M Noble
Journal: BMJ (1974)

until the patient shows better evidence of intention to co-operate in his treatment.When one operates on this sort of patient, especially through the abdomen, the main morbidity is to the surgeon's coronary arteries, both inter-and postoperatively.Finally, many surgeons already do refuse to operate on non-co-operative patients.In Mr. Duke's own specialty numbers of orthopaedic surgeons will not do major hip replacements on grossly fat patients.Some vascular surgeons refuse major reoonstructive surg.ry to patients who will not stop smoking.They argue that th-e effort and ex- pense to the nation involved will, to an extent, be wasted in those patients who con- tinue to indulge in the habit which was the main cause of their disease and will contribute to any failure of their surgery.In each case, the taking of the medical advice may make the surgery unnecessary.-I am, etc.,
The measurement of albumin leak into the gastrointestinal tract using 131I-albumin and ion exchange resin by mouth
Authors: T. Freeman, A. H. Gordon
Journal: Gut (1964)

EDITORIAL SYNOPSIS These studies cast doubt on the validity of the technique of the use of an ion exchange resin by mouth together with l31iodine-labelled albumin intravenously as a method of measuring albumin loss in the alimentary tract.
Extensive Arterial Tortuosity and Severe Aortic Dilation in a Newborn With an <i>EFEMP2</i> Mutation
Authors: Maria Iascone, Maria Elena Sana, Laura Pezzoli, Paolo Bianchi, Daniela Marchetti, Giorgio Fasolini, Youcef Sadou, Anna Locatelli, Flavia Fabiani, Giovanna Mangili, Paolo Ferrazzi
Journal: Circulation (2012)
Diagnostic Electrocardiographic Sequences in Acute Pericarditis
Authors: DAVID H. SPODICK
Journal: Circulation (1973)

Diagnostic electrocardiographic patterns were analyzed in 50 consecutive patients who had unequivocal clinical evidence of acute pericarditis. Distributions of P and QRS, and of P-R segment, ST-segment and T wave changes were plotted by lead and by mean frontal vector (Â). Transient gross deviations of P-R segments, mainly in Stages 1 and/or 2, occurred in 41 patients (82%) and could produce an optical illusion of ST elevations when the J-points were actually on the baseline. Â P-R was close to 180° opposite to Â P and was not related to P wave or heart rate changes. In Stage 1, Â ST tended to be concordant with Â QRS and Â T. T wave inversions in Stage 3 produced an Â T which was distributed over an arc of 210° with no range of predilection. Transient increase in magnitude of a normally oriented PR vector was consistent with the subepicardial atrial injury of acute pericarditis. It is the analogue of the classic Stage 1 ST-segment abnormalities of subepicardial ventricular injury and was equally as widespread in the electorcardiogram and almost as prevalent. P-R segment deviations were always depressions for leads of "epicardial" patterns. ST-segment deviations departed from the classic elevation pattern in 10 patients: 7 patients in whom ST was depressed in Lead III, 5 of whom had a horizontal QRS axis; and 3 patients in whom ST was depressed in aVL, two of whom had a vertical QRS axis. In Stage 3, the much wider range for Â T as compared with the relatively concentrated early injury vectors, Â P-R and Â ST, is ascribed to greater inhomogeneity of post-injury ventricular repolarization.
The Office of Decedent Affairs-Reply
Authors: Abida K. Haque
Journal: JAMA (1992)

In Reply.  —We thank Dr Carter for providing information on the presence of centralized pathology-based offices like ours at other institutions. We suspected that there might be such offices, but our search of the literature failed to turn up relevant publications.  The mortician  used at the University Hospitals of Cleveland is certainly similar to our Decedent Affairs Office; however, our system incorporates several additional goals, such as risk management reports, quality control and quality improvement, accurate completion of death certificates, and acquisition of tissue-organ donations. As to the type of individuals hired for this office, we chose to train these individuals ourselves simply because the cost of employing morticians would be much higher than that of a college graduate.  Carter's comment that the Mortician's Office increased autopsy rates is similar to our experience with our Decedent Affairs Office.
Combined endoscopic ultrasound-guided choledochoduodenostomy and duodenal stent placement in a patient with pancreatic cancer
Authors: R. Harada, H. Kawamoto, H. Fukatsu, K. Tsutsumi, M. Fujii, N. Kurihara, T. Ogawa, E. Ishida, Y. Okamoto, H. Okada, K. Sakaguchi
Journal: Endoscopy (2007)

A 75-year-old woman was admitted to our hospital with obstructive jaundice. Abdominal computed tomography revealed a hypovascular mass in the head of the pancreas, dilatation of the bile ducts, and tumor invasion into the second portion of the duodenum ([Fig. 1]). Small nodules were also observed in the omentum, and a diagnosis of pancreatic cancer with peritonitis carcinomatosa was made. After percutaneous transhepatic biliary drainage (PTBD) was performed to relieve the jaundice, a duodenal self-expandable metallic stent was deployed in the duodenal stricture ([Fig. 2] , [3]). Informed consent was obtained, and then a convex linear-array echo endoscope (GF-UCT2000; Olympus Co. Ltd., Tokyo, Japan) was used to puncture the dilated extrahepatic bile duct at the level of the duodenal bulb with an Olympus KD-10Q-1 needle-knife, using an electrosurgical generator (ICC200; ERBE, Tübingen, Germany). After the needle-knife was removed from the catheter, a guide wire was introduced into the bile duct under fluoroscopic guidance, and the catheter was removed. A 7-Fr biliary plastic stent (Flexima; Cook Endoscopy, Winston-Salem, North Carolina, USA) was then inserted into the left hepatic bile duct ([Fig. 4]). Once this procedure was complete, the PTBD catheter was removed ([Fig. 5]).
Oxymetazoline (OXY) Adds To The Effectiveness Of Fluticasone Furoate Nasal Spray (FFNS) In The Treatment Of Perennial Allergic Rhinitis (PAR)
Authors: M. deTineo, F.M. Baroody, D. Brown, L. Gavanescu, R.M. Naclerio
Journal: Journal of Allergy and Clinical Immunology (2011)
An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus.
Authors: J A James, K M Kaufman, A D Farris, E Taylor-Albert, T J Lehman, J B Harley
Journal: Journal of Clinical Investigation (1997)

An unknown environmental agent has been suspected to induce systemic lupus erythematosus (lupus) in man. Prompted by our recent immunochemical findings, we sought evidence for an association between Epstein-Barr virus infection and lupus. Because the vast majority of adults have been infected with Epstein-Barr virus, we chose to study children and young adults. Virtually all (116 of 117, or 99%) of these young patients had seroconverted against Epstein-Barr virus, as compared with only 70% (107 of 153) of their controls (odds ratio 49.9, 95% confidence interval 9.3-1025, P < 0. 00000000001). The difference in the rate of Epstein-Barr virus seroconversion could not be explained by serum IgG level or by cross-reacting anti-Sm/nRNP autoantibodies. No similar difference was found in the seroconversion rates against four other herpes viruses. An assay for Epstein-Barr viral DNA in peripheral blood lymphocytes established Epstein-Barr virus infection in the peripheral blood of all 32 of the lupus patients tested, while only 23 of the 32 matched controls were infected (odds ratio > 10, 95% confidence interval 2.53-infinity, P < 0.002). When considered with other evidence supporting a relationship between Epstein-Barr virus and lupus, these data are consistent with, but do not in themselves establish, Epstein-Barr virus infection as an etiologic factor in lupus.
Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial)
Authors: Zoltán H. Endre, Robert J. Walker, John W. Pickering, Geoffrey M. Shaw, Christopher M. Frampton, Seton J. Henderson, Robyn Hutchison, Jan E. Mehrtens, Jillian M. Robinson, John B.W. Schollum, Justin Westhuyzen, Leo A. Celi, Robert J. McGinley, Isaac J. Campbell, Peter M. George
Journal: Kidney International (2010)
Metastasis of Hypernephroma to Atrioventricular Node
Authors: Thomas N. James
Journal: New England Journal of Medicine (1962)

HYPERNEPHROMA is a capricious disease. Its blood-borne metastases, propensity for hemorrhage and frequently associated fever are omens of gravity, and yet it is not uncommon to read of cases in which the tumor mysteriously became quiescent for many years. Recent experience with an unusual case of hypernephroma in a patient with complete heart block is the subject of this report.Case ReportI.B.H., a 48-year-old woman, was admitted to the Henry Ford Hospital because of gradually increasing pain in the left hip for 6 months. On investigation a hypernephroma of the left kidney with metastases to the skeleton was demonstrated. . . .
Comparison of prothrombin complex concentrate and vitamin K1 in oral anticoagulant reversal.
Authors: D A Taberner, J M Thomson, L Poller
Journal: BMJ (1976)

A randomised clinical trial was undertaken to compare the value of a factor II, IX, and X concentrate (Prothromplex) with intravenous vitamin K1 (2-5 mg) in reversing an overdose of oral anticoagulants. Rapid partial correction of the prothrombin time, partial thromboplastin time, and the clotting factor assays were observed with the concentrate, but these changes were not always sustained. In contrast vitamin K1 did not show any great effect at two hours but at 24 hours there was always over-correction despite the conservative dosage, prothrombin times being shorter than the therapeutic range. The prothrombin complex concentrate provides a quicker, more controlled but less sustained method of reversing the coumarin defect than vitamin K1. But there remains a significant risk of hepatitis even with a preparation for which strenuous efforts have been made to minimise this risk by screening for hepatitis B virus. The risk should be carefully considered before such concentrates are infused in non-urgent conditions.
Double leukemias simultaneously showing lymphoblastic leukemia of the bone marrow and monocytic leukemia of the central nervous system
Authors: Yukie Ikarashi, Toshio Kakihara, Chihaya Imai, Atsushi Tanaka, Akihiro Watanabe, Makoto Uchiyama
Journal: American Journal of Hematology (2004)

Abstract A rare case of different leukemias simultaneously occurring in the bone marrow (BM) and the central nervous system (CNS) was encountered. A 4‐year‐old girl was diagnosed with acute lymphoblastic leukemia and achieved a complete remission with chemotherapy. Two years after diagnosis, she was found to have acute monocytic leukemia at first relapse in the BM. One month after the second course of induction therapy, lymphoblastic leukemia in the BM and monocytic leukemia in the CNS were found simultaneously. Chromosomal analysis of leukemia cells in the BM and CNS showed distinct results. The mechanism of double leukemias occurring was obscure, although a lineage switch, therapy‐related, or de novo leukemia could be considered as possibilities. Double leukemias should be kept in mind when leukemias relapse in several sites. Am. J. Hematol. 75:164–167, 2004. © 2004 Wiley‐Liss, Inc.
Emergency Medicine: Concepts and Clinical Practice
Authors: Richard O. Cummins
Journal: JAMA (1983)

Does the specialty of emergency medicine encompass a unique and defined body of knowledge, or is it simply a sum of many parts from other fields? If a specialty possesses singular knowledge, then its textbooks should contain information not present in other specialty books. For the past five years the two major archival works for emergency medicine have been Wilkins'<i>MGH Textbook of Emergency Medicine</i>(Williams &amp; Wilkins Co, 1978; 800 pages) and Schwartz'<i>Principles and Practice of Emergency Medicine</i>(WB Saunders Co, 1978; two volumes, 1,500 pages). Now, senior editor Peter Rosen and his associates have published an excellent textbook that confirms the growing maturity and selfconfidence of emergency medicine as a specialty and shows that it is indeed a field that encompasses special knowledge. In this book, the issue is not whether the theories or concepts of emergency medicine are unique—the basic science of emergency medicine is the
O little wolves of Leeuwenhoek.
Authors: S. Kahtan, M. Greenberg
Journal: BMJ (1992)

A breeding groundfor staphylococci~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~....... bacterial count was 69 (range 0-500) colony forming units per stethoscope.Cleaning with an alcohol soaked swab was strikingly effective: six of the 13 stethoscopes had a bacterial count >20 colony forming units before cleaning (range 23-400); in these the mean reduction in the bacterial count after cleaning was 97% (range 87%-100%).
Role Of Dendritic Cells In Allergic Reactions To Pru P 3
Authors: E. Gomez, A. Diaz-Perales, S. Lopez, L. Tordesillas, I. Doña, P. Campo, M.J. Torres, M. Blanca, G. Salcedo, C. Mayorga
Journal: Journal of Allergy and Clinical Immunology (2010)
A patient with right upper quadrant abdominal pain, hypotension and dyspnoea
Authors: P-W. Wang, P-H. Kuo, Y-C. Chang, P-C. Yang
Journal: European Respiratory Journal (2002)

A 67-yr-old female was transferred to the National Taiwan University Hospital, Tapai, Taiwan on 2 May 2001 after several days of abdominal pain, dyspnoea and hypotension. She initially complained of an intermittent cramping pain over the right upper quadrant (RUQ) of her abdomen 4 days prior to admission. Sudden onset of dyspnoea and altered mental status were noticed 2 days later. She was then sent to the emergency room of a local hospital where a body temperature of 37.5°C and blood pressure reading of 80/30 mmHg were noted. Abdominal sonography showed multiple gallstones and swelling of the gallbladder wall with the “triple-layer” sign. Her haemodynamics were stabilised by fluid challenge and empirical antibiotic therapy. She was then transferred to the National Taiwan University Hospital for further treatment.

The patient was hypertensive for several years while under regular medical control. She had also received hormone replacement therapy for treatment of osteoporosis (1 tablet·day−1 of an unknown drug for 2 yrs). Her medical history was otherwise unexceptional.

On examination, she was drowsy. Her body temperature was 37.5°C, blood pressure 160/92 mmHg, pulse rate 120 beats·min−1 and respiratory rate 24 breaths·min−1. The sclerae were not icteric. The pupils were isocoric with prompt light reflex. The neck was supple, without jugular vein distension or lymphadenopathy. The chest expanded symmetrically and breathing sounds were clear. No heart murmurs were detected. There was tenderness and muscle guarding at the RUQ abdomen with equivocal Murphy's sign. The liver and spleen were not palpable. The bowel sounds were hypoactive. No lower leg oedema was noticed. Neither skin rash nor petechiae were found. The initial laboratory studies revealed: a white blood cell count of 16.61×109 cells·L−1, with 86.2% neutrophil, 5.6% monocytes and 8.1% lymphocytes; a red blood cell count of 4.19×1012 cells·L−1; …
Laparoscopic Transcystic Papillotomy under Endoscopic Control for Bile Duct Stones
Authors: C. Feretis, B. Kalliakmanis, P. Benakis, N. Apostolidis
Journal: Endoscopy (1994)

We present here a laparoscopic transcystic papillotomy technique for the management of bile duct stones discovered either preoperatively or on intraoperative cholangiogram. Papillotomy is performed orthogradely with a hydrophilic wire-guided spincterotome inserted through the cystic duct. The correct position of the diathermic wire is verified with peroral duodenoscopy. The method has proved save and effective in our first 12 consecutive patients. Further evaluation is required to clarify its potential role in laparoscopic biliary surgery.
Childhood vulval lichen sclerosus and sexual abuse are not mutually exclusive diagnoses
Authors: J. Powell
Journal: BMJ (2000)

EDITOR—In their lesson of the week Wood and Bevan point out that failure to recognise lichen sclerosus can lead to distressing allegations of abuse.1 We agree:in a cohort of 72 girls with early onset lichen sclerosus that we studied,the possibility of sexual abuse had been raised by the general …
Effect of dietary fat on the fecal excretion of cholesterol and its degradation products in man
Authors: Richard B. Moore, Joseph T. Anderson, Henry L. Taylor, Ancel Keys, Ivan D. Frantz
Journal: Journal of Clinical Investigation (1968)

Fecal bile acid and neutral sterol excretion rates were determined in five healthy young men when serum cholesterol changes were induced by isocaloric substitution of an unsaturated (safflower oil) for a saturated fat (butter). The isotope balance method was used after the intravenous injection of cholesterol-4-(14)C. A feces extraction method is presented which permits essentially complete separation of fecal neutral sterols and bile acids. There was a significant increase in the total excretion of the fecal end products of cholesterol metabolism from 966 +/- 42 mg/day on saturated fat to 1147 +/- 45 mg/day on unsaturated fat, and the increase was equally distributed between the neutral sterol and bile acid fractions. With the substitution of dietary fats, regardless of the sequence of their feeding, there was a 28% reduction in serum cholesterol concentration during ingestion of the unsaturated fat. There were reciprocal changes in serum cholesterol levels and fecal steroid excretion with the substitution of one type of fat for the other. The changes in plasma cholesterol content were more than adequately balanced by the reciprocal changes in fecal cholesterol end product excretion. The findings in this study agree with several previous reports in supporting the hypothesis that the hypocholesteremic action of dietary unsaturated fatty acids is associated with an increase in the fecal loss of bile acids and neutral sterols.
Abstract C76: Axl signaling is required for stem cell traits and metastasis in breast cancer
Authors: Crina Tiron, Fanny Pelissier, Katarzyna Wnuk-Lipinska, Ingunn Stefansson, Reeta Virtakoivu, Masaru Miyano, Tone Sandal, David Micklem, James Garbe, Martha Stampfer, Johanna Ivaska, Lars Akslen, Mark LaBarge, James Lorens
Journal: Cancer Research (2013)

Abstract Epithelial-to-mesenchymal transition (EMT) endows carcinoma cells with migratory, survival and stem cell-like attributes that facilitate therapeutic resistance and metastasis. Expression of the Axl receptor tyrosine kinase in breast cancer correlates with EMT, poor survival and is prevalent in patient metastases. Axl upregulation in mammary epithelial cells by EMT-transcription factors, TGFbeta or hypoxia, establishes an autocrine-signaling loop with its ligand, Gas6. Inhibition of Axl signaling blocks EMT/ cancer stem cell traits including invasiveness, drug resistance, mammosphere formation, in vivo tumor initiation, and prevents spontaneous metastasis in orthotopic breast cancer models. Congruently, we show that Axl is expressed on mammary epithelial stem/progenitor cells and regulates multipotent progenitor activity. Thus Axl signal transduction represents a novel regulatory pathway linking normal mammary stem/progenitor cells and breast cancer stem cell activity. Clinical Axl-inhibitors represent a novel therapeutic opportunity to treat aggressive breast cancer. Citation Format: Crina Tiron, Fanny Pelissier, Katarzyna Wnuk-Lipinska, Ingunn Stefansson, Reeta Virtakoivu, Masaru Miyano, Tone Sandal, David Micklem, James Garbe, Martha Stampfer, Johanna Ivaska, Lars Akslen, Mark LaBarge, James Lorens. Axl signaling is required for stem cell traits and metastasis in breast cancer. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr C76.
Ibuprofen does not impair renal function in patients undergoing infrarenal aortic surgery with epidural anaesthesia
Authors: A. Brinkmann, W. Seeling, E. Kneitinger, N. Vogt, P. Radermacher, M. Georgieff, C. F. Wolf, G. Steinbach, K. H. Orend
Journal: Intensive Care Medicine (1998)
Renal outcomes associated with invasive versus conservative management of acute coronary syndrome: propensity matched cohort study
Authors: M. T. James, M. Tonelli, W. A. Ghali, M. L. Knudtson, P. Faris, B. J. Manns, N. Pannu, P. D. Galbraith, B. R. Hemmelgarn
Journal: BMJ (2013)

<b>Objectives</b> To examine the association of early invasive management of acute coronary syndrome with adverse renal outcomes and survival, and to determine whether the risks or benefits of early invasive management differ in people with pre-existing chronic kidney disease. <b>Design</b> Propensity score matched cohort study. <b>Setting</b> Acute care hospitals in Alberta, Canada, 2004-09. <b>Participants</b> 10 516 adults with non-ST elevation acute coronary syndrome. <b>Interventions</b> Participants were stratified by baseline estimated glomerular filtration rate and matched 1:1 on their propensity score for early invasive management (coronary catheterisation within two days of hospital admission). <b>Main outcome measures</b> Risks of acute kidney injury, kidney injury requiring dialysis, progression to end stage renal disease, and all cause mortality were compared between those who received early invasive treatment versus conservative treatment. <b>Results</b> Of 10 516 included participants, 4276 (40.7%) received early invasive management. After using propensity score methods to assemble a matched cohort of conservative management participants with characteristics similar to those who received early invasive management (n=6768), early invasive management was associated with an increased risk of acute kidney injury (10.3% <i>v</i> 8.7%, risk ratio 1.18, 95% confidence interval 1.03 to 1.36; P=0.019), but no difference in the risk of acute kidney injury requiring dialysis (0.4% <i>v</i> 0.3%, 1.20, 0.52 to 2.78; P=0.670). Over a median follow-up of 2.5 years, the risk of progression to end stage renal disease did not differ between the groups (0.3 <i>v</i> 0.4 events per 100 person years, hazard ratio 0.91, 95% confidence interval 0.55 to 1.49; P=0.712); however, early invasive management was associated with reduced long term mortality (2.4 <i>v</i> 3.4 events per 100 person years, 0.69, 0.58 to 0.82; P&lt;0.001). These associations were consistent among people with pre-existing reduced estimated glomerular filtration rate and with alternate definitions for early invasive management. <b>Conclusions</b> Compared with conservative management, early invasive management of acute coronary syndrome is associated with a small increase in risk of acute kidney injury but not dialysis or long term progression to end stage renal disease.
Quality of life, depression, and fatigue among persons co-infected with HIV and hepatitis C receiving antiretroviral therapy: Outcomes from a population-based cohort
Authors: P. Braitstein, V. Montessori, K. Chan, J.S.G. Montaner, M.T. Schechter, M.V. O'Shaughnessy, R.S. Hogg
Journal: Journal of Hepatology (2003)
Colchicine's Other Indication — Effect of FDA Action
Authors: Wayne W. Grody, Terri Getzug
Journal: New England Journal of Medicine (2010)

To the Editor: The decision by the Food and Drug Administration (FDA) to approve and grant exclusive licensing of an expensive brand-name formulation (Colcrys) of the decades-old generic drug colchicine, has generated much surprise and discussion, as reported by Kesselheim and Solomon in their Perspective article (June 3 issue).1 However, most of the commentary to date has focused on the most familiar indication for colchicine, the treatment of acute gout. We would argue that the drug's other indication, the long-term treatment of familial Mediterranean fever (FMF),2 deserves equal attention. We direct UCLA's Familial Mediterranean Fever Clinic, the largest clinic dedicated . . .