Understanding the Combined Effects of Conventional Risk Factors and Genetic Loci on Diabetes Incidence
Authors: Jongoh Kim
Journal: Annals of Internal Medicine (2009)

Letters1 December 2009Understanding the Combined Effects of Conventional Risk Factors and Genetic Loci on Diabetes IncidenceJongoh Kim, MDJongoh Kim, MDFrom Albert Einstein Medical Center, Philadelphia, PA 19141.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-11-200912010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the article by Cornelis and colleagues (1). Studies have evaluated the risks for diabetes associated with comorbid conditions or behavioral factors (conventional risk factors) (2) and with some genetic loci (3, 4). Cornelis and colleagues presented combined effects of conventional risk factors and genetic loci for the first time. However, the presented data were insufficient to show the whole picture of the combined effects. The authors did not explain in detail how genetic loci and conventional risk factors were related or how the effects of genetic loci were adjusted by conventional risk factors. ...References1. Cornelis MC, Qi L, Zhang C, Kraft P, Manson J, Cai T, et al. Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med. 2009;150:541-50. [PMID: 19380854] LinkGoogle Scholar2. Perry IJ, Wannamethee SG, Walker MK, Thomson AG, Whincup PH, Shaper AG. Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men. BMJ. 1995;310:560-4. [PMID: 7888929] CrossrefMedlineGoogle Scholar3. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007;445:881-5. [PMID: 17293876] CrossrefMedlineGoogle Scholar4. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, et al; Wellcome Trust Case Control Consortium (WTCCC). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007;316:1336-41. [PMID: 17463249] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Albert Einstein Medical Center, Philadelphia, PA 19141.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoJoint Effects of Common Genetic Variants on the Risk for Type 2 Diabetes in U.S. Men and Women of European Ancestry Marilyn C. Cornelis , Lu Qi , Cuilin Zhang , Peter Kraft , JoAnn Manson , Tianxi Cai , David J. Hunter , and Frank B. Hu Understanding the Combined Effects of Conventional Risk Factors and Genetic Loci on Diabetes Incidence Marilyn C. Cornelis and Frank B. Hu Metrics 1 December 2009Volume 151, Issue 11Page: 824-825KeywordsBody mass indexConflicts of interestGeneticsMedical risk factorsObesity ePublished: 1 December 2009 Issue Published: 1 December 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...