tbuckley/cabot-search huggingface dataset:
Histone Deacetylase Inhibitors Repress Tumoral Expression of the Proinvasive Factor RUNX2
Authors: Valentina Sancisi, Greta Gandolfi, Davide Carlo Ambrosetti, Alessia Ciarrocchi
Journal: Cancer Research (2015)

Aberrant reactivation of embryonic pathways occurs commonly in cancer. The transcription factor RUNX2 plays a fundamental role during embryogenesis and is aberrantly reactivated during progression and metastasization of different types of human tumors. In this study, we attempted to dissect the molecular mechanisms governing RUNX2 expression and its aberrant reactivation. We identified a new regulatory enhancer element, located within the RUNX2 gene, which is responsible for the activation of the RUNX2 promoter and for the regulation of its expression in cancer cells. Furthermore, we have shown that treatment with the anticancer compounds histone deacetylase inhibitor (HDACi) results in a profound inhibition of RUNX2 expression, which is determined by the disruption of the transcription-activating complex on the identified enhancer. These data envisage a possible targeting strategy to counteract the oncongenic function of RUNX2 in cancer cells and provide evidence that the cytotoxic activity of HDACi in cancer is not only dependent on the reactivation of silenced oncosuppressors but also on the repression of oncogenic factors that are necessary for survival and progression.
Protective effect of an aldose reductase inhibitor against bone loss in galactose-fed rats: Possible involvement of the polyol pathway in bone metabolism
Authors: Masaaki Inaba, Makoto Terada, Yoshiki Nishizawa, Atsushi Shioi, Eiji Ishimura, Shuzo Otani, Hirotoshi Morii
Journal: Metabolism (1999)
Passive smoking in pregnancy
Authors: D. S Crowley, M. Geary
Journal: BMJ (1998)

EDITOR—In the issue of 18 October several original papers and an editorial by Davis1 highlighted the importance of passive smoking—an issue that deserves to receive widespread publicity. The problem of passive smoking in pregnancy remains underappreciated by both healthcare workers and the public.

Smoking in pregnancy is associated with numerous complications for both mother and baby. Effects start in utero, resulting in increased perinatal mortality and morbidity and the sudden infant death syndrome.2 Many pregnant women appreciate that their own cigarette smoking …
Barium swallow and ultrasound in diagnosis of gastro-oesophageal reflux in children
Authors: D R Naik, A Bolia, D J Moore
Journal: BMJ (1985)

should not deter other groups who want to see such a team established in their own area.It does make the point, however, that support teams need to be set up with great care, with adequate funding and proper commitment, if they are to be successful.There needs to be a single consultant in charge, with at least one other doctor and, wherever possible, a full time social worker plus at least two nursing sisters.We believe that the appointment of a single unsupported nurse, instead of a properly funded team, will inevitably prove a recipe for disaster.
Abstract 1261: Targeting IL-11Rα inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model
Authors: Valerae O. Lewis, Eswaran Devarajan, Dennis PM Hughes
Journal: Cancer Research (2014)

Abstract Osteosarcoma is the most common primary tumor of bones. In the past three decades treatment paradigms and survival rates have not improved. While osteosarcoma clinical phenotype has been well characterized, the underlying tumor molecular biology remains unclear. We have previously demonstrated that IL-11Rα is overexpressed in primary and metastatic osteosarcoma. Recently investigators identified that IL-11 and IL-11Rα play a role in the development of metastasis in breast and gastrointestinal cancer. However the role of IL-11/IL-11Rα signaling in osteosarcoma is unknown. Using in vitro and in vivo osteosarcoma models we investigated the role of IL-11/IL-11Rα in osteosarcoma metastasis. The purpose of our study is to determine the effect of the knockdown of IL-11Rα in osteosarcoma. We stably knocked down IL-11Rα expression in a highly metastatic osteosarcoma cell line, using a lentiviral short hair-pin (shRNA) based approach. Knockdown of IL-11Rα led to inhibition of STAT-3(Tyr705) protein phosphorylation, cell growth, migration, invasion and colony formation in vitro. To determine the role of IL-11Rα in osteosarcoma tumorigeniesis and metastasis, we used an orthotopic metastatic model. In this model, mice injected with KRIB-IL-11Rα shRNA cells developed significantly less metastasis than control mice injected with KRIB control shRNA (P&amp;lt;0.01). The relevance of our data to human conditions was studied by immunohistochemical staining of IL-11Rα protein in human osteosarcoma biopsy samples containing primary tumor and lesions, significant difference (p&amp;lt;0.01) in expression distribution between primary and metastatic osteosarcoma lesions and a trend toward an impact on survival was noted. In conclusion, we showed that IL-11Rα plays an important role in the development of metastasis in osteosarcoma and blockade of this axis may inhibit the formation of metastasis and may provide an excellent target for the treatment of osteosarcoma. Citation Format: Valerae O. Lewis, Eswaran Devarajan, Dennis PM Hughes. Targeting IL-11Rα inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1261. doi:10.1158/1538-7445.AM2014-1261
Task Force V: The relation of cardiovascular specialists to industry, institutions and organisations
Authors: C.Richard Conti, John F. Williams, Jeffrey L. Anderson, Harris A. Berman, Rolf M. Gunnar, Gerald P. Herman, Fred W. Lyons, Eugene R. Passamani, Philip R. Reid, Mark E. Silverman, Sylvan Lee Weinberg, Lee Yerkes
Journal: Journal of the American College of Cardiology (1990)
TNFA2 and d2 alleles of the tumor necrosis factor alpha gene polymorphism are associated with onset/occurrence of idiopathic membranous nephropathy
Authors: D. Thibaudin, L. Thibaudin, P. Berthoux, C. Mariat, J.-P. Filippis, B. Laurent, E. Alamartine, F. Berthoux
Journal: Kidney International (2007)
Re: Prognostic Significance of a Short Sequence Insertion in the MCL-1 Promoter in Chronic Lymphocytic Leukemia
Authors: Daniel Iglesias-Serret, Llorenç Coll-Mulet, Antonio F. Santidrián, Àurea Navarro-Sabaté, Alicia Domingo, Gabriel Pons, Joan Gil
Journal: JNCI Journal of the National Cancer Institute (2005)

Wt = wild-type allele; 6 = 6-nucleotide insertion; 18 = 18-nucleotide insertion.† B-CLL = B-cell chronic lymphocytic leukemia
Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin
Authors: Stephen A. Harrison, Fayez M. Hamzeh, Jian Han, Prashant K. Pandya, Muhammed Y. Sheikh, John M. Vierling
Journal: Hepatology (2012)

Patients with chronic hepatitis C and insulin resistance are less likely to respond to anti-hepatitis C virus (HCV) therapy and are at risk for more rapid fibrosis progression. Coadministration of pioglitazone with peginterferon/ribavirin improves insulin sensitivity and increases virologic response rates in insulin-resistant HCV genotype 4 patients, but it is unclear whether this finding applies to genotype 1 patients. For this reason we randomized treatment-naive HCV genotype 1 patients with insulin resistance to receive either standard care (peginterferon alpha-2a plus ribavirin for 48 weeks, n = 73) or pioglitazone 30-45 mg/day plus standard care (n = 77) in an open-label multicenter trial. Patients randomized to pioglitazone received the drug during a 16-week run-in phase, the 48-week standard-care phase, and the 24-week untreated follow-up phase. Pioglitazone treatment improved hemoglobin A1c (HbA1c), plasma glucose, insulin levels, and homeostasis model assessment of insulin resistance score and increased serum adiponectin levels during the 16-week run-in phase and maintained these improvements during the standard-care phase. However, we observed no statistically significant difference between the two groups in the primary efficacy endpoint, the decrease from baseline to Week 12 of peginterferon alpha-2a/ribavirin treatment in mean log10 HCV RNA titer (−3.5 ± 1.71 and −3.7 ± 1.62 IU/mL in the pioglitazone and standard-care groups, respectively, Δ = 0.21 IU/mL, P = 0.4394). Conclusion : Treatment with pioglitazone before and during treatment with peginterferon alpha-2a plus ribavirin improved several indices of glycemic control in patients with chronic hepatitis C and insulin resistance, but did not improve virologic response rates compared with peginterferon alpha-2a plus ribavirin alone. (HEPATOLOGY 2012)
Expanding Access to Hepatitis C Virus Treatment—Extension for Community Healthcare Outcomes (ECHO) Project: Disruptive Innovation in Specialty Care†
Authors: Sanjeev Arora, Summers Kalishman, Karla Thornton, Denise Dion, Glen Murata, Paulina Deming, Brooke Parish, John Brown, Miriam Komaromy, Kathleen Colleran, Arthur Bankhurst, Joanna Katzman, Michelle Harkins, Luis Curet, Ellen Cosgrove, Wesley Pak
Journal: Hepatology (2010)

Abstract The Extension for Community Healthcare Outcomes (ECHO) Model was developed by the University of New Mexico Health Sciences Center as a platform to deliver complex specialty medical care to underserved populations through an innovative educational model of team-based interdisciplinary development. Using state-of-the-art telehealth technology, best practice protocols, and case-based learning, ECHO trains and supports primary care providers to develop knowledge and self-efficacy on a variety of diseases. As a result, they can deliver best practice care for complex health conditions in communities where specialty care is unavailable. ECHO was first developed for the management of hepatitis C virus (HCV), optimal management of which requires consultation with multidisciplinary experts in medical specialties, mental health, and substance abuse. Few practitioners, particularly in rural and underserved areas, have the knowledge to manage its emerging treatment options, side effects, drug toxicities, and treatment-induced depression. In addition, data were obtained from observation of ECHO weekly clinics and database of ECHO clinic participation and patient presentations by clinical provider. Evaluation of the ECHO program incorporates an annual survey integrated into the ECHO annual meeting and routine surveys of community providers about workplace learning, personal and professional experiences, systems and environmental factors associated with professional practice, self-efficacy, facilitators, and barriers to ECHO. The initial survey data show a significant improvement in provider knowledge, self-efficacy, and professional satisfaction through participation in ECHO HCV clinics. Clinicians reported a moderate to major benefit from participation. We conclude that ECHO expands access to best practice care for underserved populations, builds communities of practice to enhance professional development and satisfaction of primary care clinicians, and expands sustainable capacity for care by building local centers of excellence.
Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice
Authors: Briony A. Cutts, Anna-Karin M. Sjogren, Karin M. E. Andersson, Annika M. Wahlstrom, Christin Karlsson, Birgitta Swolin, Martin O. Bergo
Journal: Blood (2009)
Royalty payments to staff researchers cause new NIH troubles
Authors: Janice Hopkins Tanne
Journal: BMJ (2005)

Patients who took part in clinical trials at the US National Institutes of Health (NIH) had no idea that scientists at the institutes received $8.9m (£4.8m; €6.8m) in royalty payments and might benefit financially for the use of their discoveries by pharmaceutical companies and device makers, reports from Associated Press allege. This information was not made public until the press agency obtained the information after filing a request under the Freedom of Information Act.

The press agency has reported that 916 present and former NIH researchers received annual royalty payments averaging $9700 but …
Hematochyli in Man and Animals
Authors: Charles E. Lucas
Journal: JAMA (1966)

Dumont and Mulholland<sup>1 2</sup>in 1962 were the first to describe gross contamination of the thoracic-duct lymph with blood in man. They made the observation in 20 patients with Laennec's cirrhosis and postulated that this phenomenon resulted from an increased hepatic sinusoidal pressure. In this condition, red blood cells are presumed to lead from the sinusoids into the hepatic lymphatics. However, this conclusion is not substantiated by a considerable number of experimental studies in which inferior vena caval or hepatic venous constriction has been used in the production of ascites in dogs.<sup>3-5</sup>Such animals exhibit a similar increase in thoracic-duct flow rate to that described by Dumont and Mulholland in man, but no instance of hematochyli has been described. We became interested in this area when animals with chronic abdominal arteriovenous fistulas, being studied for unrelated purposes, were found to have bloody chyle. An experimental study, therefore, was
Phenotypic Variability in RDH5 Retinopathy (Fundus Albipunctatus)
Authors: Panagiotis I. Sergouniotis, Elliott H. Sohn, Zheng Li, Vikki A. McBain, Genevieve A. Wright, Anthony T. Moore, Anthony G. Robson, Graham E. Holder, Andrew R. Webster
Journal: Ophthalmology (2011)
Sequential azacitidine and lenalidomide in patients with high-risk myelodysplastic syndromes and acute myeloid leukaemia: a single-arm, phase 1/2 study
Authors: Courtney D DiNardo, Naval Daver, Elias Jabbour, Tapan Kadia, Gautam Borthakur, Marina Konopleva, Naveen Pemmaraju, Hui Yang, Sherry Pierce, William Wierda, Carlos Bueso-Ramos, Keyur P Patel, Jorge E Cortes, Farhad Ravandi, Hagop M Kantarjian, Guillermo Garcia-Manero
Journal: The Lancet Haematology (2014)
Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation
Authors: Jennifer L. Kielczewski, Yagna P.R. Jarajapu, Evan L. McFarland, Jun Cai, Aqeela Afzal, Sergio Li Calzi, Kyung Hee Chang, Todd Lydic, Lynn C. Shaw, Julia Busik, Jeffrey Hughes, Arturo J. Cardounel, Kenneth Wilson, Timothy J. Lyons, Michael E. Boulton, Robert N. Mames, Tailoi Chan-Ling, Maria B. Grant
Journal: Circulation Research (2009)

Rationale : Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior, specifically stimulating EPC cell migration. This study was undertaken to investigate the mechanism of IGFBP-3 effects on EPC function and how IGFBP-3 mediates cytoprotection following vascular injury. Objective : To examine the mechanism of IGFBP-3–mediated repair following vascular injury. Methods and Results : We used 2 complementary vascular injury models: laser occlusion of retinal vessels in adult green fluorescent protein (GFP) chimeric mice and oxygen-induced retinopathy in mouse pups. Intravitreal injection of IGFBP-3–expressing plasmid into lasered GFP chimeric mice stimulated homing of EPCs, whereas reversing ischemia induced increases in macrophage infiltration. IGFBP-3 also reduced the retinal ceramide/sphingomyelin ratio that was increased following laser injury. In the OIR model, IGFBP-3 prevented cell death of resident vascular endothelial cells and EPCs, while simultaneously increasing astrocytic ensheathment of vessels. For EPCs to orchestrate repair, these cells must migrate into ischemic tissue. This migratory ability is mediated, in part, by endogenous NO generation. Thus, we asked whether the migratory effects of IGFBP-3 were attributable to stimulation of NO generation. IGFBP-3 increased endothelial NO synthase expression in human EPCs leading to NO generation. IGFBP-3 exposure also led to the redistribution of vasodilator-stimulated phosphoprotein, an NO regulated protein critical for cell migration. IGFBP-3–mediated NO generation required high-density lipoprotein receptor activation and stimulation of phosphatidylinositol 3-kinase/Akt pathway. Conclusion : These studies support consideration of IGFBP-3 as a novel agent to restore the function of injured vasculature and restore NO generation.
P76Notch signaling up-regulation in diabetic epicardial adipose-tissue stem cells and angiogenic function
Authors: MT Bejar, R Ferrer-Lorente, L Badimon
Journal: Cardiovascular Research (2014)

Purpose: Type 2 diabetes mellitus patients have an increased risk of developing atherosclerosis and coronary heart disease. The epicardial adipose tissue is a reservoir of adipose-tissue mesenchymal stem cells (EAT-ASCs), with yet unknown effects on myocardial and coronary arteries homeostasis. The aim of this study has been to elucidate the regulation of EAT-ASCs function in diabetes.
Acquired Weakness, Handgrip Strength, and Mortality in Critically Ill Patients
Authors: Naeem A. Ali, James M. O'Brien, Stephen P. Hoffmann, Gary Phillips, Allan Garland, James C. W. Finley, Khalid Almoosa, Rana Hejal, Karen M. Wolf, Stanley Lemeshow, Alfred F. Connors, Clay B. Marsh
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Section:ChooseTop of pageAbstract <<METHODSRESULTSDISCUSSIONAPPENDIX AAPPENDIX B: EXCLUSION CRI...APPENDIX CReferencesCITING ARTICLES
Studies Made By Simulating Systole at Necropsy
Authors: ISAAC STARR, T. G. SCHNABEL, S. I. ASKOVITZ, A. SCHILD
Journal: Circulation (1954)

Data derived from experiments on cadavers have been used to test old methods and to design new methods of estimating cardiac stroke volume from estimations of blood pressure, made both by intra-arterial and standard clinical technics. From the data has been derived a method of estimating stroke volume from pulse pressure, diastolic pressure and age, which has reasonably good accuracy in the cadaver experiments, and which is so simple that it could be easily applied by any physician using the apparatus he now has.
The Symptomatic Adolescent Five Years Later: He Didn't Grow Out of It
Authors: JAMES F. MASTERSON
Journal: American Journal of Psychiatry (1967)

Follow-up of a group of "symptomatic adolescents" five years after initial evaluation indicated that, for them, adolescence was but a way station in a long history of psychiatric illness that began in childhood and followed its own inexorable course. Indiscriminate adherence to the theory that the symptomatic adolescent will "grow out" of his difficulties, the author concludes, may discourage the therapeutic intervention necessary to interrupt the progression to marked adult psychiatric illness.
Perinatal mortality and severe morbidity in low and high risk term pregnancies in the Netherlands: prospective cohort study
Authors: A. C. C. Evers, H. A. A. Brouwers, C. W. P. M. Hukkelhoven, P. G. J. Nikkels, J. Boon, A. van Egmond-Linden, J. Hillegersberg, Y. S. Snuif, S. Sterken-Hooisma, H. W. Bruinse, A. Kwee
Journal: BMJ (2010)

To compare incidences of perinatal mortality and severe perinatal morbidity between low risk term pregnancies supervised in primary care by a midwife and high risk pregnancies supervised in secondary care by an obstetrician.Prospective cohort study using aggregated data from a national perinatal register.Catchment area of the neonatal intensive care unit (NICU) of the University Medical Center in Utrecht, a region in the centre of the Netherlands covering 13% of the Dutch population.Pregnant women at 37 weeks' gestation or later with a singleton or twin pregnancy without congenital malformations.Perinatal death (antepartum, intrapartum, and neonatal) or admission to a level 3 NICU.During the study period 37 735 normally formed infants were delivered at 37 weeks' gestation or later. Sixty antepartum stillbirths (1.59 (95% confidence interval 1.19 to 1.99) per 1000 babies delivered), 22 intrapartum stillbirths (0.58 (0.34 to 0.83) per 1000 babies delivered), and 210 NICU admissions (5.58 (4.83 to 6.33) per 1000 live births) occurred, of which 17 neonates died (0.45 (0.24 to 0.67) per 1000 live births). The overall perinatal death rate was 2.62 (2.11 to 3.14) per 1000 babies delivered and was significantly higher for nulliparous women compared with multiparous women (relative risk 1.65, 95% confidence interval 1.11 to 2.45). Infants of pregnant women at low risk whose labour started in primary care under the supervision of a midwife had a significant higher risk of delivery related perinatal death than did infants of pregnant women at high risk whose labour started in secondary care under the supervision of an obstetrician (relative risk 2.33, 1.12 to 4.83). NICU admission rates did not differ between pregnancies supervised by a midwife and those supervised by an obstetrician. Infants of women who were referred by a midwife to an obstetrician during labour had a 3.66 times higher risk of delivery related perinatal death than did infants of women who started labour supervised by an obstetrician (relative risk 3.66, 1.58 to 8.46) and a 2.5-fold higher risk of NICU admission (2.51, 1.87 to 3.37).Infants of pregnant women at low risk whose labour started in primary care under the supervision of a midwife in the Netherlands had a higher risk of delivery related perinatal death and the same risk of admission to the NICU compared with infants of pregnant women at high risk whose labour started in secondary care under the supervision of an obstetrician. An important limitation of the study is that aggregated data of a large birth registry database were used and adjustment for confounders and clustering was not possible. However, the findings are unexpected and the obstetric care system of the Netherlands needs further evaluation.
A Case of Retropharyngeal Soft-Tissue Swelling: The Definitive Diagnosis Revealed
Authors: Carlo A. Ippolito
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The authors of the article, "Retropharyngeal Soft-Tissue Swelling in an Elderly Man,"<sup>1</sup>did not present an all inclusive list in the differential diagnosis. A 12-year-old boy was brought to my office complaining of swelling in the back of his throat. Finger palpation revealed nontender soft-tissue swelling of the posterial pharynx and soft tissue of the lateral part of the neck. An x-ray film confirmed a mass extending to the cricopharyngeal level. The removed mass proved to be a schwannoma. The only sequela following the surgery was Horner's syndrome. This neural sheath tumor should be included in differential diagnosis.<sup>2</sup>
Dicyclomine
Authors: Jesse Woodard, Badreddine Bencherif, Maria Clavell, Judith Joyce
Journal: Clinical Nuclear Medicine (2011)

Hepatobiliary scintigraphy with sincalide stimulation is a commonly performed examination to evaluate gall bladder function. The importance of fasting and the possible interference by opioids are well-known considerations in the preparation of patients for this study. We present another medication, dicyclomine, that may interfere with the validity of the results. A 16-year-old girl with abdominal pain underwent hepatobiliary scintigraphy with sincalide stimulation that demonstrated a decreased gall bladder ejection fraction of 3%. Because of concern for the potential anticholinergic effect of dicyclomine therapy, this medication was discontinued, and a repeat examination revealed a normal ejection fraction of 97%.
STUDIES ON THE LEUKOCYTOSIS AND LYMPHOCYTOSIS INDUCED BY BORDETELLA PERTUSSIS
Authors: Stephen I. Morse, Sallie K. Riester
Journal: The Journal of Experimental Medicine (1967)

By the use of radioautographic techniques it was shown that the lymphocytosis induced by Bordetella pertussis in mice was not caused by an increased production of lymphocytes but was primarily due to the entry into the circulation of mature cells from tissue pools. The accompanying polymorphonuclear leukocytosis was due to both proliferation of myeloid elements and entry of mature cells from tissue reserves, with the former the predominant mechanism.