tbuckley/cabot-search huggingface dataset:
Prospective evaluation of eligibility for thrombolytic therapy in acute myocardial infarction
Authors: J. K French, B. F Williams, H. H Hart, S. Wyatt, J. E Poole, C. Ingram, C. J Ellis, M. G Williams, H. D White
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To determine the proportion of patients presenting with acute myocardial infarction who are eligible for thrombolytic therapy. <b>Design</b>: Cohort follow up study. <b>Setting</b>: The four coronary care units in Auckland, New Zealand. <b>Subjects</b>: All 3014 patients presenting to the units with suspected myocardial infarction in 1993. <b>Main outcome measures</b>: Eligibility for reperfusion with thrombolytic therapy (presentation within 12 hours of the onset of ischaemic chest pain with ST elevation &gt;/=2 mm in leads V1-V3, ST elevation &gt;/=1 mm in any other two contiguous leads, or new left bundle branch block); proportions of (a) patients eligible for reperfusion and (b) patients with contraindications to thrombolysis; death (including causes); definite myocardial infarction. <b>Results</b>: 948 patients had definite myocardial infarction, 124 probable myocardial infarction, and nine ST elevation but no infarction; 1274 patients had unstable angina and 659 chest pain of other causes. Of patients with definite or probable myocardial infarction, 576 (53.3%) were eligible for reperfusion, 39 had definite contraindications to thrombolysis (risk of bleeding). Hence 49.7% of patients (537/1081) were eligible for thrombolysis and 43.5% (470) received this treatment. Hospital mortality among patients eligible for reperfusion was 11.7% (55/470 cases) among those who received thrombolysis and 17.0% (18/106) among those who did not. <b>Conclusions</b>: On current criteria about half of patients admitted to coronary care units with definite or probable myocardial infarction are eligible for thrombolytic therapy. Few eligible patients have definite contraindications to thrombolytic therapy. Mortality for all community admissions for myocardial infarction remains high. <h3>Key messages</h3> Less than 10% of patients eligible for reperfusion have contraindications to thrombolysis The hospital mortality for all patients with acute myocardial infarction remains high (14%) Better treatments are required to reduce mortality in both reperfusion eligible and reperfusion ineligible patients
Complex Partial Seizures Simulating Schizophrenia
Authors: Victor R. Adebimpe
Journal: JAMA (1977)

The clinical features that distinguish schizophrenia from the symptomatic psychoses were seen in a patient whose complex partial seizures remained undiagnosed for five years, resulting in 30 psychiatric hospitalizations. (<i>JAMA</i>237:1339-1341, 1977)
Narration
Authors: S. M. Rabson
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The prickly problem of access to insulin
Authors: D. Cohen
Journal: BMJ (2011)

<h3>Abstract</h3> Diagnosis of rare, genetic diseases is challenging, but conceptual frameworks of the diagnostic process can be used to guide benchmarking and process improvement initiatives. Using the National Academy of Medicine diagnostic framework, we assessed the extent of, and reasons for diagnostic delays and diagnostic errors in schwannomatosis, a neurogenetic syndrome characterized by nerve sheath tumors and chronic pain. We reviewed the medical records of 97 people with confirmed or probable schwannomatosis seen in two U.S. tertiary care clinics. Time-to-event analysis revealed a median time from first symptom to diagnosis of 16.7 years (95% CI, 7.5-26.0 years) and median time from first medical consultation to diagnosis of 9.8 years (95% CI, 3.5-16.2 years). Factors associated with longer times to diagnosis included initial signs/symptoms that were intermittent, non-specific, or occurred at younger ages (p&lt;0.05). Thirty-six percent of patients experienced a misdiagnosis of their underlying genetic condition (18.6%), pain etiology (16.5%) and/or tumor classification (11.3%). One-fifth (19.6%) of patients had a clear missed opportunity for genetics workup that could have led to an earlier schwannomatosis diagnosis. These results suggest that interventions in clinician education, genetic testing availability, expert review of pathology findings, and automatic triggers for genetics referrals may improve diagnosis of schwannomatosis.
Developmental biology of gut-probiotic interaction
Authors: Ravi Mangal Patel, Patricia W. Lin
Journal: Gut Microbes (2010)

While our current knowledge of probiotic interaction in the developing gut remains poorly understood, emerging science is providing greater biological insight into their mechanism of action and therapeutic potential for human disease. Given their beneficial effects, probiotics remain promising agents in neonatal gastrointestinal disorders. Probiotics may restore or supply essential bacterial strains needed for gut maturation and homeostasis, particularly in hosts where this process has been disrupted. Here we highlight the unique characteristics of developing intestinal epithelia with a focus on gut development and colonization as well as the inflammatory propensity of immature epithelia. Additionally, we review potential mechanisms of beneficial probiotic interaction with immature intestinal epithelia including immunomodulation, upregulation of cytoprotective genes, prevention and regulation of apoptosis, and maintenance of barrier function. Improved knowledge of gut-probiotic interaction in developing epithelia will allow for a better understanding of how probiotics exert their beneficial effects and help guide their therapeutic use.
Enzyme histochemistry and its application in the study of neoplasms.
Authors: J. F. A. McManus
Journal: JAMA (1963)

Dr. Burstone is one of the more active contributors to the field of enzymatic histochemistry, both in developing and applying new and original techniques. He has now gathered together in this book his own experience and that of the many others in the field to produce a well-printed, clear and concise description of current enzymatic methods in histochemistry. Many results of the applications of these techniques, particularly in regard to neoplasia, are described. Illustrations, many in color, are plentiful and excellent. After preliminary chapters on fixation and embedding procedures and on the methods by which enzymes can be demonstrated in tissue sections, special chapters are devoted to the phosphatases, esterases, sulfatases, glycosidases, transglycosylases, proteolytic enzymes, oxidases, and dehydrogenases. There is a chapter on the newer field that applies
PROBLEMS OF ANESTHESIA FOR SURGICAL PROCEDURES WITHIN THE CHEST
Authors: McKinnie L. Phelps
Journal: JAMA (1953)

Surgical procedures involving opening of the thoracic space have multiplied in incidence and variety many times in the past decade and even in the past five years. With the advent of new techniques and drugs, surgery involving the lungs has become commonplace as compared with 1942. Esophageal surgery, ranging from that for carcinoma in the aged to repair of tracheoesophageal fistula in the newborn, is capably done over the entire country. Certain neurosurgical procedures may involve entry into the pleural space, and intrathoracic cardiac or vascular surgery has been developed in recent years to a spectacular degree. Most sizable communities are beginning to regard operations on the mitral valve or coarctation of the aorta as operations with definite indications and predictably bright prognoses. Such being the case, it seems desirable that referring physicians should have some conception of the problems, accidents, and complications encountered in the operating room in the
Quadrivalent HPV vaccine prevented HPV infection and external genital lesions in boys and men 16 to 26 years of age
Authors: Bradley S. Bender
Journal: Annals of Internal Medicine (2011)

ACP Journal Club17 May 2011Quadrivalent HPV vaccine prevented HPV infection and external genital lesions in boys and men 16 to 26 years of ageBradley S. Bender, MDBradley S. Bender, MDNorth Florida/South Georgia Veterans Health System, Gainesville, Florida, USA (B.S.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-10-201105170-02010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationGiuliano AR, Palefsky JM, Goldstone S, et al. Efficacy of quadrivalent HPV vaccine against HPV infection and disease in males. N Engl J Med. 2011;364:401-11. https://pubmed.ncbi.nlm.nih.gov/21288094Clinical Impact RatingsInfectious Disease: References1 Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2006. MMWR. 2006;55:1-94. www.cdc.gov/mmwr/preview/mmwrhtml/rr5511a1.htm (accessed 6 Apr 2011). Google Scholar2 Zimet GD, Weiss TW, Rosenthal SL, Good MB, Vichnin MD. Reasons for non-vaccination against HPV and future vaccination intentions among 19-26 year-old women. BMC Womens Health. 2010;10:27. [PMID: 20809965] Google Scholar3 Kim JJ. Focus on research: weighing the benefits and costs of HPV vaccination of young men. N Engl J Med. 2011;364:393-5. [PMID: 21288093] Google Scholar Author, Article, and Disclosure InformationAuthors: Bradley S. Bender, MDAffiliations: North Florida/South Georgia Veterans Health System, Gainesville, Florida, USA (B.S.B.)This article was published at Annals.org on 3 May 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 May 2011Volume 154, Issue 10Page: JC5-10KeywordsDNAGenital anatomyHeterosexualsHuman papillomavirusHuman papillomavirus infectionInfectious diseasesLesionsSexually transmitted diseasesVaccinesWarts ePublished: 17 May 2011 Issue Published: 17 May 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Haemothorax in the course of chickenpox.
Authors: E Rodriguez, J Martinez, M Javaloyas, F Nonell, M Torres
Journal: Thorax (1986)

Varicella pneumonia develops in 10-20% of cases of chickenpox occurring in adolescence or adult life.' Airflow obstruction, pleural effusion, and respiratory failure are less frequent.2Although several haemorrhagic pleuropulmonary complications have been described in the course of chickenpox, haemothorax has been observed only once.3We describe a new case of this association.
Local Postsynaptic Voltage-Gated Sodium Channel Activation in Dendritic Spines of Olfactory Bulb Granule Cells
Authors: Wolfgang G. Bywalez, Dinu Patirniche, Vanessa Rupprecht, Martin Stemmler, Andreas V.M. Herz, Dénes Pálfi, Balázs Rózsa, Veronica Egger
Journal: Neuron (2015)
1101-41 Intravascular ultrasound assessment of lesions with sirolimus-eluting stent failure
Authors: Hideo Takebayashi, Yoshio Kobayashi, Gary S Mintz, Kenichi Fujii, Takenori Yasuda, Roxana Mehran, David Jacoboff, George D Dangas, Alexandra J Lansky, Issam Moussa, Michael B Collins, Edward Kreps, Gregg W Stone, Martin B Leon, Jeffrey W Moses
Journal: Journal of the American College of Cardiology (2004)
Body surface distribution of electrical potential during atrial depolarization and repolarization.
Authors: D M Mirvis
Journal: Circulation (1980)

Limited information is available documenting body surface isopotential distributions during atrial excitation and recovery. To expand the current data base, body surface isopotential maps from 40 normal subjects were examined. Data were acquired at a gain of 10,000 and isopotential distributions constructed at 2-msec intervals from the onset of the P wave to the onset of the QRS complex. During the initial half of the P wave, a left midprecordial maximum dominated the distribution. Negative potentials existed over the upper back. Subsequently, the maximum migrated to the left; negative potentials moved into precordial areas. Near the end of the P wave, the maximum shifted to the left back as a minimum evolved over the midprecordium. This minimum increased in intensity and remained stationary throughout the PR segment. These patterns are consistent with previously reported epicardial records from canine preparations documenting initial right and then left atrial activation, and repolarization beginning before the end of excitation and enveloping much of the posterior atrial epicardium with low-level positive potential. All distributions had but a single maximum and/or minimum, consistent with a single dipole equivalent cardiac generator.
Creating a Safer Health Care System
Authors: Stephen G. Pauker, Ellen M. Zane, Deeb N. Salem
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characterization of oral immune cells in birch pollen-allergic patients: impact of the oral allergy syndrome and sublingual allergen immunotherapy on antigen-presenting cells
Authors: L. Mascarell, S. Rak, M. Worm, M. Melac, S. Soulie, G. Lescaille, F. Lemoine, F. Jospin, S. Paul, L. Caplier, B. Hasséus, C. Björhn, R. K. Zeldin, V. Baron-Bodo, P. Moingeon
Journal: Allergy (2015)

A detailed characterization of human oral immune cells is needed to better understand local mechanisms associated with allergen capture following oral exposure.Oral immune cells were characterized by immunohistology and immunofluorescence in biopsies obtained from three healthy individuals and 23 birch pollen-allergic patients with/without oral allergy syndrome (OAS), at baseline and after 5 months of sublingual allergen immunotherapy (AIT).Similar cell subsets (i.e., dendritic cells, mast cells, and T lymphocytes) were detected in oral tissues from healthy and birch pollen-allergic individuals. CD207+ Langerhans cells (LCs) and CD11c+ myeloid dendritic cells (DCs) were found in both the epithelium and the papillary layer of the Lamina propria (LP), whereas CD68+ macrophages, CD117+ mast cells, and CD4+ /CD8+ T cells were rather located in both the papillary and reticular layers of the LP. Patterns of oral immune cells were identical in patients with/without OAS, except lower numbers of CD207+ LCs found in oral tissues from patients with OAS, when compared to OAS- patients (P < 0.05). A 5-month sublingual AIT had a limited impact on oral immune cells, with only a significant increase in IgE+ cells in patients from the active group. Colocalization experiments confirmed that such IgE-expressing cells mostly encompass CD68+ macrophages located in the LP, and to a lesser extent CD207+ LCs in the epithelium.Two cell subsets contribute to antigen/allergen uptake in human oral tissues, including (i) CD207+ LCs possibly involved in the physiopathology of OAS and (ii) CD68+ macrophages likely critical in allergen capture via IgE-facilitated mechanisms during sublingual AIT.
Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development
Authors: Antonina Giammanco, Valerie Blanc, Grace Montenegro, Coen Klos, Yan Xie, Susan Kennedy, Jianyang Luo, Sung-Hee Chang, Timothy Hla, ILKe Nalbantoglu, Sekhar Dharmarajan, Nicholas O. Davidson
Journal: Cancer Research (2014)

HuR is a ubiquitous nucleocytoplasmic RNA-binding protein that exerts pleiotropic effects on cell growth and tumorigenesis. In this study, we explored the impact of conditional, tissue-specific genetic deletion of HuR on intestinal growth and tumorigenesis in mice. Mice lacking intestinal expression of HuR (Hur (IKO) mice) displayed reduced levels of cell proliferation in the small intestine and increased sensitivity to doxorubicin-induced acute intestinal injury, as evidenced by decreased villus height and a compensatory shift in proliferating cells. In the context of Apc(min/+) mice, a transgenic model of intestinal tumorigenesis, intestinal deletion of the HuR gene caused a three-fold decrease in tumor burden characterized by reduced proliferation, increased apoptosis, and decreased expression of transcripts encoding antiapoptotic HuR target RNAs. Similarly, Hur(IKO) mice subjected to an inflammatory colon carcinogenesis protocol [azoxymethane and dextran sodium sulfate (AOM-DSS) administration] exhibited a two-fold decrease in tumor burden. Hur(IKO) mice showed no change in ileal Asbt expression, fecal bile acid excretion, or enterohepatic pool size that might explain the phenotype. Moreover, none of the HuR targets identified in Apc(min/+)Hur(IKO) were altered in AOM-DSS-treated Hur(IKO) mice, the latter of which exhibited increased apoptosis of colonic epithelial cells, where elevation of a unique set of HuR-targeted proapoptotic factors was documented. Taken together, our results promote the concept of epithelial HuR as a contextual modifier of proapoptotic gene expression in intestinal cancers, acting independently of bile acid metabolism to promote cancer. In the small intestine, epithelial HuR promotes expression of prosurvival transcripts that support Wnt-dependent tumorigenesis, whereas in the large intestine epithelial HuR indirectly downregulates certain proapoptotic RNAs to attenuate colitis-associated cancer. Cancer Res; 74(18); 5322-35. ©2014 AACR.
Primary or secondary sicca complex? Investigation in primary biliary cirrhosis by histocompatibility testing.
Authors: A N Hamlyn, D Adams, S Sherlock
Journal: BMJ (1980)

<h3>ABSTRACT</h3> Gene duplications have greatly shaped the gene content of plants. Multiple factors, such as the epigenome, can shape the subsequent evolution of duplicate genes and are the subject of ongoing study. We analyze genic DNA methylation patterns in 43 angiosperm species and 928 <i>Arabidopsis thaliana</i> ecotypes to finding differences in the association of whole-genome and single-gene duplicates with genic DNA methylation patterns. Whole-genome duplicates were enriched for patterns associated with higher gene expression and depleted for patterns of non-CG DNA methylation associated with gene silencing. Single-gene duplicates showed variation in DNA methylation patterns based on modes of duplication (tandem, proximal, transposed, and dispersed) and species. Age of gene duplication was a key factor in the DNA methylation of single-gene duplicates. In single-gene duplicates, non-CG DNA methylation patterns associated with silencing were younger, less conserved, and enriched for presence-absence variation. In comparison, DNA methylation patterns associated with constitutive expression were older and more highly conserved. Surprisingly, across the phylogeny, genes marked by non-CG DNA methylation were enriched for duplicate pairs with evidence of positive selection. We propose that DNA methylation has a role in maintaining gene-dosage balance and silencing by non-CG methylation and may facilitate the evolutionary fate of duplicate genes.
1107. Gene Therapy Clinical Trials for Relapsed Leukemia with Infusions of the Suicide-Gene Transduced Donor Lymphocytes in Japan
Authors: Masafumi Onodera, Shin Kaneko, Makoto Otsu, Hiroshi Kojima, Ryo Sumazaki, Salvatore Toma, Chiara Bonini, Claudio Bordignon, Hiromitsu Nakauchi, Toshiro Nagasawa
Journal: Molecular Therapy (2006)

Donor lymphocytes function as a double-edged sword in allogeneic stem cell transplantation (allo-SCT), that is, they attack leukemic cells (graft versus leukemia-GVL) as well as patient's normal tissues such as liver, intestines, and skin, (graft versus host disease-GVHD). The strong GVL reaction has made an infusion of donor lymphocytes (DLI) an effective treatment for relapsed leukemia after allo-SCT, especially for relapse of chronic myelogenous leukemia. However, the use of DLI is severely limited by the risk of a potential life- threatening complication, GVHD. A phase I/II clinical study of DLI using donor lymphocytes transduced with a retroviral vector carrying the herpes simplex virus thymidine kinase (HSV-TK) gene for patients affected by relapsed leukemia after allo-SCT started at the Tsukuba University Hospital in 2004 as the first clinical trial of leukemia gene therapy in Japan. This is aimed at control of severe GVDH by administration of ganciclovir (GCV) if it occurs while maintaining the maximum GVL effects. So far, we have done eight transduction procedures and infused the HSV-TK transduced donor lymphocytes into 4 patients (2 AML, 1 ALL, and 1 MDS). All patients received about 1x108 cells per kilogram of body weight. In the result, three out of four patients showed good responses such as inhibition of leukemic cell growth and lowering the values of molecular markers after infusions of the transduced cells. One AML patient showed complete remission and no relapse signs are observed on 6 months after the treatment. One patient developed grade III GVHD, and was successfully treated with ganciclovir, in the absence of immunesuppressive drugs. No adverse effects related to gene therapy are observed. Other trials for relapsed leukemia are under way. Details of the present study including additional cases will be presented.
Juvenile Delinquents View Their Impulsivity
Authors: RICHARD C. MAROHN, DANIEL OFFER, ERIC OSTROV
Journal: American Journal of Psychiatry (1971)

This study of 24 hospitalized adolescent delinquents revealed that the delinquents were well aware of their impulsivity. This awareness was related not to age, sex, race, police contact, or incarceration but to objective measures of impulsivity. In some impulsive delinquents, internal awareness of their intrapsychic inability to control and modulate impulses was blocked and was projected onto the outside world; it was experienced as a feeling of doom or helplessness about the future.