tbuckley/cabot-search huggingface dataset:
Tongue Lesions in Treated Pernicious Anemia
Authors: William S. Beck
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of Reduced Maternal Exposures to Wood Smoke from an Introduced Chimney Stove on Newborn Birth Weight in Rural Guatemala
Authors: Lisa M. Thompson, Nigel Bruce, Brenda Eskenazi, Anaite Diaz, Daniel Pope, Kirk R. Smith
Journal: Environmental Health Perspectives (2011)

Background: A growing body of evidence indicates a relationship between household indoor air pollution from cooking fires and adverse neonatal outcomes, such as low birth weight (LBW), in resource-poor countries.Objective: We examined the effect of reduced wood smoke exposure in pregnancy on LBW of Guatemalan infants in RESPIRE (Randomized Exposure Study of Pollution Indoors and Respiratory Effects).Methods: Pregnant women (n = 266) either received a chimney stove (intervention) or continued to cook over an open fire (control). Between October 2002 and December 2004 we weighed 174 eligible infants (69 to mothers who used a chimney stove and 105 to mothers who used an open fire during pregnancy) within 48 hr of birth. Multivariate linear regression and adjusted odds ratios (ORs) were used to estimate differences in birth weight and LBW (&lt; 2,500 g) associated with chimney-stove versus open-fire use during pregnancy.Results: Pregnant women using chimney stoves had a 39% reduction in mean exposure to carbon monoxide compared with those using open fires. LBW prevalence was high at 22.4%. On average, infants born to mothers who used a stove weighed 89 g more [95% confidence interval (CI), –27 to 204 g] than infants whose mothers used open fires after adjusting for maternal height, diastolic blood pressure, gravidity, and season of birth. The adjusted OR for LBW was 0.74 (95% CI, 0.33–1.66) among infants of stove users compared with open-fire users. Average birth weight was 296 g higher (95% CI, 109–482 g) in infants born during the cold season (after harvest) than in other infants; this unanticipated finding may reflect the role of maternal nutrition on birth weight in an impoverished region.Conclusions: A chimney stove reduced wood smoke exposures and was associated with reduced LBW occurrence. Although not statistically significant, the estimated effect was consistent with previous studies.
CD Rom: Minor Surgery and Skin Lesions: Diagnosis and Management on CD-ROM
Authors: M A Casson
Journal: BMJ (1999)

Roger Kneebone, Julia Schofield Primal Pictures, London, $65 ISBN 1 902470052 Rating:![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Minor Surgery and Skin Lesions presents in a spectacular way minor surgical techniques, and I have never seen them illustrated before with such clarity. The cartoon-like animations and the clear sound track answer many questions that, because of their apparent simplicity, are never asked lest the questioner betrays his ignorance, like the emperor's new clothes. Having practised minor surgery in general practice for 30years, I found … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
DETECTION OF BREAKPOINTS IN SUBMICROSCOPIC CHROMOSOMAL TRANSLOCATION, ILLUSTRATING AN IMPORTANT MECHANISM FOR GENETIC DISEASE
Authors: J. Lamb, P.C. Harris, R.H. Lindenbaum, S.T. Reeders, A.O.M. Wilkie, V.J. Buckle, N.J. Barton, D.J. Weatherall, D.R. Higgs
Journal: The Lancet (1989)
Idiopathic Pulmonary Fibrosis Another Cause of Ventilation/Perfusion Mismatch
Authors: JANET F. EARY, MARK C. FISHER, MANUEL D. CERQUEIRA
Journal: Clinical Nuclear Medicine (1986)

A case of isiopathic pulmonary fibrosis, presenting as a single segmental perfusion defect without a corresponding ventilatory abnormality in a patient suspected of having a pulmonary embolus is reported. This has not been reported previously in the literature.
Factor V inhibitor in thrombosis
Authors: Ashok Kapur, Paul R. Kelsey, Peter E. T. Isaacs
Journal: American Journal of Hematology (1993)

A 68-year-old previously well woman developed sudden onset of limb gangrene in association with liver dysfunction. An immediately acting inhibitor to factor V with some of the features of lupus anticoagulant was demonstrated. The patient required limb amputation within 2 weeks and activity of the anticoagulant seemed to be on the decline 6 months later.
Randomized Clinical Trials and Patient Preferences
Authors: Aroop Mangalik, James Neidhart
Journal: Annals of Internal Medicine (1992)

Letters15 October 1992Randomized Clinical Trials and Patient PreferencesAroop Mangalik, MD, James Neidhart, MDAroop Mangalik, MDSearch for more papers by this author, James Neidhart, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-8-700_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Levine and colleagues (1), presented a useful tool for eliciting patient preference for adjuvant chemotherapy that gives a statistical perspective on the risks and benefits. However, they did not discuss another major and important method of dealing with the uncertainty of the situation in node-negative breast cancer: participation in randomized clinical trials. Not enough patients are being enrolled in clinical trials, making it difficult to answer important clinical questions such as those concerning risks and benefits in different sub-populations (2, 3).By participating in a clinical trial, the patient gets information about the current state of knowledge...References1. LevineAmiramMarkhamMacFarlane MGBD. A bedside decision instrument to elicit a patient's preference concerning adjuvant chemotherapy for breast cancer. Ann Intern Med. 1992;117:53-8. LinkGoogle Scholar2. BensonPreglerBeanRademakerEshlerAnderson AJJABK. Oncologists' reluctance to accrue patients onto clinical trials: An Illinois Cancer Center study. J Clin Oncol. 1991;9:2067-75. CrossrefMedlineGoogle Scholar3. Editorial on Clinical Trial Participation. J Clin Oncol. 1991;9:1927-30. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of New Mexico Cancer Center Albuquerque, NM 87131 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1992Volume 117, Issue 8Page: 700-700KeywordsAdjuvant chemotherapyBreast cancerClinical trials Issue Published: 15 October 1992 PDF DownloadLoading ...
Efficacy and safety of the new 60-mg formulation of the long-acting somatostatin analog lanreotide in the treatment of acromegaly
Authors: Maria Rosaria Ambrosio, Paola Franceschetti, Marta Bondanelli, Mauro Doga, Pietro Maffei, Roberto Baldelli, Guido Tamburrano, Nicola Sicolo, Andrea Giustina, Ettore C. degli Uberti
Journal: Metabolism (2002)
Anencephalic Infants as Organ Donors
Authors: Brock L. Eide
Journal: JAMA (1995)

To the Editor.  —In reversing its historical opposition to the use of live anencephalic neonates as organ donors, the Council on Ethical and Judicial Affairs of the American Medical Association (AMA) 1 has wandered far from traditional notions of ethical medical practice and basic human rights.  Thomas Jefferson, in defining the basic rights of citizenship, appealed to the concept of self-evident rights 2 —rights conferred neither by institutions nor by individuals, but belonging to human beings as such. These rights were  and could not be relinquished (or alienated), even voluntarily. Because we recognize that individuals possess such inalienable rights to life and liberty we do not allow them to forfeit their lives by donating their essential organs or to voluntarily sell themselves into slavery.  In abandoning the concept of an inalienable right to life, the Council has abandoned a fundamental safeguard of human life and liberty. In deciding that
Promoter polymorphisms in CHI3L1 are associated with asthma
Authors: Dominique J. Verlaan, Manon Ouimet, Veronique Adoue, Dave Sirois-Gagnon, Mathieu Larivière, Bing Ge, Patrick Beaulieu, Joana Dias, Kevin C.L. Lam, Vonda Koka, Catherine Laprise, Tomi Pastinen, Daniel Sinnett
Journal: Journal of Allergy and Clinical Immunology (2012)
Why We Rarely Know About Drugs
Authors: Theodore Greiner
Journal: JAMA (1961)

A plea is made for wide concern among physicians for the relatively simple methods of examining the efficacy of new drugs in patients. A distinction must be made between examining of the individual patient and statistical proof from large series. The latter, the process of systematic verification, is generally so difficult, tedious, and slow as to discourage hopes for development of a rational drug therapy. The alternative process, thoughtful observation combined with clinical intuition, has led to important developments in the past and should not be neglected. The mutual interaction of these 2 processes is essential to the advancement of therapeutics.
Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147
Authors: W. Xie, H. Xie, F. Liu, W. Li, J. Dan, Y. Mei, L. Dan, X. Xiao, J. Li, X. Chen
Journal: British Journal of Dermatology (2013)

Infantile haemangiomas (IHs) are benign tumours in infancy. Most patients suffering from IHs do not require treatment. However, if there is a dramatic aesthetic or functional impairment, treatment is needed. Currently the most promising therapy for complicated IHs is the oral administration of propranolol, but its mechanism is unclear.To investigate the role of CD147 in propranolol-induced apoptosis in human umbilical vein endothelial cells (HUVECs).Human umbilical vein endothelial cells were treated with propranolol, and the treatment effects were investigated through the following methodology. (i) Cell proliferation and apoptosis were detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometric analysis. (ii) The expression level of CD147 was measured by reverse-transcription polymerase chain reaction and Western blotting. (iii) HUVECs were transfected with lentivirus encoding CD147 short hairpin (sh)RNA or CD147 cDNA. Ensuing changes in cell proliferation and apoptosis after transfection were measured using the MTT assay and flow cytometry. (iv) The level of phosphorylation of Bcl-2-associated death promoter (BAD) at Ser112 in HUVECs after propranolol treatment and/or CD147 shRNA transfection was detected by Western blotting.Propranolol inhibited cell proliferation and induced apoptosis in HUVECs. It decreased CD147 protein expression in a concentration-dependent manner. Knocking down CD147 not only induced apoptosis but also exacerbated the apoptosis triggered by propranolol in HUVECs. Overexpression of CD147 can protect HUVECs from apoptosis and propranolol-induced apoptosis. Furthermore, knockdown of both propranolol and CD147 can downregulate Ser112 phosphorylation of BAD, indicating that propranolol and CD147 induce apoptosis in HUVECs through the same signalling transduction pathway.Our studies demonstrate that propranolol-induced apoptosis may be mediated through the downregulation of CD147 in HUVECs. This study highlights a novel step in propranolol action and suggests a potential new target for the treatment of IHs.
The Aortic Arch Syndrome (Pulseless Disease)
Authors: W. M. THURLBECK, J. H. CURRENS
Journal: Circulation (1959)

Ten patients are presented in whom absent arterial pulsations were noted in 1 or both arms. Six patients also had absent carotid arterial pulsations on 1 or both sides. The blood pressure was determined satisfactorily by a machine devised to record the Korotkov vibrations. This indicates feeble arterial pulsation in spite of inability to palpate them clinically. Three autopsied cases showed severe atherosclerosis with superimposed thrombosis. Long-term anticoagulation used in 2 patients for as long as 3 years seemed to result in some clinical improvement.
Letter: Looking after schizophrenics.
Authors: W Sargant
Journal: BMJ (1974)

ceivably be playing a part in the aetiology of other disease entities,9 and halogenated salicylanilides and related compounds may not be the only drugs retained in this manner.'0Dr. R. H. Champion, in the article "Diseases of the Skin: Drug Therapy of Urticaria" (22 December 1973, p. 730) states that "antihistamine drugs may, if necessary, be continued for months or years with safety."How can he be sure of this?How can we be certain that any of the photosensitizing drugs which cover a wide therapeutic range and include several anti- histamines are not retained in the dermis for long periods, eventually playing a part in the production of actinic reticuloid in sus- ceptible subjects?Promethazine, an anti- histamine, and chlorpromazine, a tran- quillizer, two phenothiazine derivatives, may cause persistent photodermatitis which depends upon concomitant oral administration and external application."'3The active photocontact sensitizers cause multiple cross- sensitivities'4 and it is conceivable that one or several photosensitizing drugs retained in the dermis might be immunologically activated by an external powerful sensitizer such as fenticlor, leading to actinic reticu- loid.-Iam, etc.,
Normal splanchnic but impaired peripheral insulin-stimulated glucose uptake in cirrhosis
Authors: Ehoud Shmueli, Mark Walker, George Alberti, Christopher O. Record
Journal: Hepatology (1993)

The site of impaired glucose uptake in cirrhosis is uncertain. We therefore performed hyperglycemic clamps (glucose 10 mmol/L) in 10 patients with compensated alcoholic cirrhosis and impaired glucose tolerance and in six control subjects. Muscle glucose uptake was estimated in patients and controls with the forearm technique. In the cirrhotic subjects splanchnic glucose uptake was measured with hepatic vein catheterization and primed continuous infusions of indocyanine green and [6-3H]glucose. To assess insulin-independent glucose uptake and the effects of elevated nonesterified fatty acid levels on glucose uptake, we repeated the study with somatostatin to induce insulin deficiency and a nicotinic acid analog, acipimox, to inhibit lipolysis. Substrate disposal was assessed on indirect calorimetry. Despite similar stimulated insulin levels, total glucose utilization was lower in the cirrhotic subjects (3.9 +/- 0.3 vs. 8.8 +/- 1.7 mg/kg/min, p = 0.006). This deficiency was accounted for by lower nonoxidative glucose disposal (1.2 +/- 0.2 vs. 5.8 +/- 1.6 mg/kg/min, p = 0.002). Forearm glucose uptake was lower in the cirrhotic subjects (0.39 +/- 0.06 vs. 1.21 +/- 0.3 mg/100 ml/min, p = 0.001). However, splanchnic glucose uptake at 1.59 +/- 0.14 mg/kg/min was similar to that reported in other studies of normal subjects. Insulin-independent glucose uptake was normal, and acipimox had no effect on total or forearm glucose utilization. Glucose intolerance in cirrhosis is characterized by impaired peripheral insulin-stimulated non-oxidative glucose disposal. The high nonesterified fatty acid levels seen in cirrhosis most likely do not contribute to this defect. Splanchnic glucose uptake is normal in cirrhosis.
262 POLYCYSTIN-1 AND – 2 PLAY A KEY ROLE IN THE MODULATION OF CHOLANGIOCYTE PROLIFERATION
Authors: M. Gatto, A. Torrice, V. Cardinale, M.C. Bragazzi, M.G. Mancino, R. Semeraro, G. Alpini, D. Alvaro
Journal: Journal of Hepatology (2009)
Acanthamoeba Keratitis in Soft Contact Lens Wearers
Authors: Jeanette K. Stehr-Green
Journal: JAMA (1987)

<i>Acanthamoeba</i>keratitis is a rare, serious protozoal infection of the cornea associated with wearing contact lenses. To identify risk factors in soft contact lens wearers, we interviewed 27 patients with<i>Acanthamoeba</i>keratitis and 81 uninfected matched controls to compare contact lens care practices, brands of contact lenses and associated solutions, and behavioral activities. Patients were significantly more likely than controls to use homemade saline instead of commercially prepared saline (21/27 [78%] vs 14/81 [17%]; odds ratio [OR], ∞), and wear their lenses while swimming (17/27 [63%] vs 24/81 [30%]; OR, 6.2). Contact lens disinfection schedules could be determined for 25 of the patients and all of the controls. Patients were significantly more likely than controls to disinfect their lenses less frequently than recommended by lens manufacturers (18/25 [72%] vs 26/81 [32%]; OR, 5.8). Microbiologic assay of contact lens solutions from controls showed frequent contamination with high levels of bacteria.<i>Acanthamoeba</i>species were isolated from homemade saline solutions from two controls. These findings emphasize adherence to recommended methods of soft contact lens care, especially when using nonsterile lens care solutions. (<i>JAMA</i>1987;258:57-60)
Cardiac Positron Emission Tomography Enhances Prognostic Assessments of Patients With Suspected Cardiac Sarcoidosis
Authors: Ron Blankstein, Michael Osborne, Masanao Naya, Alfonso Waller, Chun K. Kim, Venkatesh L. Murthy, Pedram Kazemian, Raymond Y. Kwong, Michifumi Tokuda, Hicham Skali, Robert Padera, Jon Hainer, William G. Stevenson, Sharmila Dorbala, Marcelo F. Di Carli
Journal: Journal of the American College of Cardiology (2013)
Interstitial Nephritis and Cimetidine
Authors: DEXTER H. HAKE
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 March 1981Interstitial Nephritis and CimetidineDEXTER H. HAKE, M.D.DEXTER H. HAKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-3-416_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to report a case of interstitial nephritis secondary to the use of cimetidine (1, 2).A 57-year-old male engineer was seen 14 November 1979 with symptoms of peptic esophagitis. At that time, he had normal laboratory findings, including urinalysis data, creatinine, and hematocrit. There was no history or evidence of prior renal disease. He was effectively treated with cimetidine.He was seen again 2 February 1980 after a trip to Mexico, because of fever. Results of examination and laboratory studies were normal, including creatinine, but the hematocrit was lower at 38. Stools were guaiac...References1. LINTONCLARKDRIEDGERTURNBILLLINDSAY AWADR. Acute interstitial nephritis due to drugs: review of the literature with a report of nine cases. Ann Intern Med. 1980;93:735-41. LinkGoogle Scholar2. MCGOWANVERMILLION WS. Acute interstitial nephritis related to cimetidine therapy. Gastroenterology. 1980;79:746-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNephrotoxicity and Hepatotoxicity of Histamine H2 Receptor AntagonistsInterstitial NephritisToxic NephropathiesImmunologically Mediated Nephritis Induced by Toxins and DrugsChanges in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents: IICimetidine-drug interactionsImmunologic Studies in Cimetidine-Induced Nephropathy and PolymyositisCimetidine-Induced Acute Renal FailureMICHAEL R. RUDNICK, M.D., CHRISTINE P. BASTL, M.D., I. B. ELFENBEIN, M.D., ROBERT A. SIROTA, M.D., MELVIN YUDIS, M.D., ROBERT G. NARINS, M.D.Antihistamines 1 March 1981Volume 94, Issue 3Page: 416-416KeywordsCreatinineEngineersFeversHematocritNephritisRenal diseasesResearch laboratories Issue Published: 1 March 1981 PDF DownloadLoading ...
Coronary Artery Disease: Recognition and Management
Authors: Charles B. Clayman
Journal: JAMA (1979)

An exemplary product of the Specialized Center of Research on Ischemic Heart Disease founded by Dr Tinsley R. Harrison has been created by his latter-day descendants Drs Rackley and Russell and their colleagues at the University of Alabama Medical Center, Division of Cardiology. An efficiently organized, complete discussion of almost every aspect of coronary artery disease is presented for the primary care physician as well as for the student and the cardiologist. In clear language the authors introduce the reader to the problem, its natural history, manifestations, as well as factors in etiology and prognosis, including consideration of singleor multiple-vessel disease and left ventricular function. Noninvasive methods of evaluation, including kinetocardiography, echocardiography, exercise testing, and radionucleide study, are completely explained, and the reader is well able to appreciate the limits and benefits of each of these procedures. Arteriography, cardiac catheterization to evaluate left ventricular function, and left ventricular biplane angiography
Socioeconomic variation in admission for diseases of female genital system and breast in a national cohort aged 15-43
Authors: D. Kuh, S. Stirling
Journal: BMJ (1995)

<h3>Abstract</h3> <b>Objective</b>: To investigate socioeconomic variation among young women in the risk of hospital admission for diseases (including neoplasms) of the female genital system and breast and for the common surgical procedures of dilatation and curettage and hysterectomy. <b>Design</b>: Large nationally representative cohort study with individual records of confirmed admissions to NHS and private hospitals since birth and data on occupational and educational experience. <b>Setting</b>: England, Scotland, and Wales. <b>Patients</b>: General population sample of 1628 women, 1549 of whom had a complete admissions record for the ages of 15-43 years. <b>Main outcome measures</b>: The percentage of women admitted for neoplasms or other diseases of the female genital system and breast or who had dilatation and curettage or hysterectomy beween the ages of 15 and 43 years. <b>Results</b>: By the age of 43, 35% of women had been admitted, 17% had undergone dilatation and curettage at least once, and 10% had had a hysterectomy. There were significant inverse educational gradients, the risk of admission increasing more than twofold between the most and least educated women. The differential risk was most striking for disorders of menstruation, in which only 1% of those with the highest educational qualifications and 19% of those with minimal qualifications had been admitted to hospital. There was a significant educational gradient in the hysterectomy rate (from 1% to 15%) and a twofold difference in the risk of dilatation and curettage. There were also significant gradients in risk of admission and of hysterectomy according to partner9s social class. <b>Conclusions</b>: Socioeconomic variations in the risk of dilatation and curettage and of hysterectomy were large. Lessening the socioeconomic gradient in risks of admissions and surgery for diseases of the female genital system and breast, particularly for menstrual disorders, could have important resource implications.