Warfarin and Phenytoin Interaction
Authors: Jean M. Nappi
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 May 1979Warfarin and Phenytoin InteractionJEAN M. NAPPI, PHARM.D.JEAN M. NAPPI, PHARM.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-5-852_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their excellent review on antiepileptic drugs in the February issue, Drs. Penry and Newmark (1) note that dicumarol may prolong the half-life of phenytoin. The potential interaction of warfarin and phenytoin was not mentioned and deserves attention, since both of these drugs are commonly prescribed.The package insert (2) does not list phenytoin as a drug that can influence the prothrombin time of a patient maintained on warfarin therapy. Deykin (3), however, includes phenytoin in a group of drugs that may potentiate the action of warfarin, presumably by inhibiting its metabolism. Koch-Weser (4) has reported this...References1. PENRYNEWMARK JM: The use of antiepileptic drugs. Ann Intern Med 90:207-218, 1979 LinkGoogle Scholar2. Product information. Garden City, New York, Endo Laboratories, Inc., March 1977 Google Scholar3. DEYKIN D: Warfarin therapy. N Engl J Med 283:801-803, 1970 CrossrefMedlineGoogle Scholar4. KOCH-WESER J: Hemorrhagic reactions and drug interactions in 500 warfarin-treated patients (abstract). Clin Pharmacol Ther 14:139, 1973 Google Scholar5. Adverse interactions of drugs. Med Lett Drugs Ther 21:5-12, 26 January 1979 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: School of Pharmacy University of Wisconsin Madison WI 53706 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAntiepileptic drugs in critically ill patientsWarfarin Interaction With Hepatic Cytochrome P-450 Enzyme-Inducing AnticonvulsantsCardiovascular DrugsCoumarin anticoagulantsEffect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitorSeizures in the acute stroke settingCardiovascular DrugsAdverse Drug Reactions and Drug Interactions as Causes of Hospital Admission in OncologyA Mechanistic Approach to Antiepileptic Drug InteractionsDrug interactions in oncology: how common are they?Management of new-onset epilepsy in the elderlyANTICOAGULANTS, THROMBOLYTIC AGENTS, AND ANTI-PLATELET DRUGSRisk and Predictability of Drug Interactions in the ElderlyCoumarin anticoagulantsPharmacological and clinical aspects of antiepileptic drug use in the elderlyEpilepsy in the ElderlyA Mechanistic Approach to Antiepileptic Drug InteractionsCytochrome P450 EnzymesSelection of Antiepileptic Drugs: A Practical ApproachCytochrome P450 EnzymesFatal phenytoin warfarin interaction.Antiepileptic Drug InteractionsHerzrhythmusstörungenPharmakokinetische Prinzipien und spezielle Pharmakokinetik der AntiarrhythmikaA Comparative Evaluation of Oral Anticoagulant-Phenytoin InteractionsDrugs affecting blood clotting and fibrinolysis 1 May 1979Volume 90, Issue 5Page: 852-852KeywordsAntiepileptic drugDrug interactionsDrug metabolismDrug therapyDrugsHalf lifeProthrombin time Issue Published: 1 May 1979 PDF DownloadLoading ...