tbuckley/cabot-search huggingface dataset:
Evaluation Of Specific Sequential IgE- and IgG4-binding Epitopes, Recognized in Cow's Milk Allergic Patients during Specific Oral Desensitization, using Peptide Microarray Immunoassay.
Authors: V. Pecora, E. Nucera, D. Schiavino, C. Lombardo, L. Bardina, J. Lin, M. Goldis, G. Patriarca, H.A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2009)
Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision
Authors: Jennifer L. Ecker, Olivia N. Dumitrescu, Kwoon Y. Wong, Nazia M. Alam, Shih-Kuo Chen, Tara LeGates, Jordan M. Renna, Glen T. Prusky, David M. Berson, Samer Hattar
Journal: Neuron (2010)
Testing time for side room tests
Authors: J G Collee
Journal: BMJ (1988)

<h3>Abstract</h3> Detecting the presence of important parasites within a host and its environment is critical to understanding the dynamics that influence a pathogens ability to persist, while accurate detection is also essential for implementation of effective control strategies. <i>Pseudoloma neurophilia</i> is the most common pathogen reported in zebrafish (<i>Danio rerio</i>) research facilities. The only assays currently available for <i>P. neurophilia</i>, are through lethal sampling, often requiring euthanasia of the entire population for accurate estimates of prevalence in small populations. We present a non-lethal screening method to detect <i>Pseudoloma neurophilia</i> in tank water based on detection of environmental DNA (eDNA) from this microsporidum, using a previously developed qPCR assay that was adapted to the digital PCR (dPCR) platform. Using the generated dPCR data, a multi-state occupancy model was also implemented to predict the probability of detection in tank water under different flow regimes and pathogen prevalence. The occupancy model revealed that samples collected in static conditions were more informative than samples collected from flow-through conditions, with a probability of detection at 80% and 47%, respectively. There was also a positive correlation with the prevalence of infection in water and prevalence in fish based on qPCR.
What forms the chunks in a subject's performance? Lessons from the CHREST computational model of learning
Authors: Peter C.R. Lane, Fernand Gobet, Peter C-H. Cheng
Journal: Behavioral and Brain Sciences (2001)

Computational models of learning provide an alternative technique for identifying the number and type of chunks used by a subject in a specific task. Results from applying CHREST to chess expertise support the theoretical framework of Cowan and a limit in visual short-term memory capacity of 3–4 looms. An application to learning from diagrams illustrates different identifiable forms of chunk.
Persistent Campylobacter jejuni Infections in Patients Infected with Human Immunodeficiency Virus (HIV)
Authors: DANIEL M. PERLMAN
Journal: Annals of Internal Medicine (1988)

We identified Campylobacter jejuni infections in four patients infected with the human immunodeficiency virus (HIV); three had persistent and severe C. jejuni infections. Multiple isolates obtained from each patient had the same biochemical and serotypic characteristics, indicating recurrent infection rather than reinfection with unrelated strains. Serum antibody responses to C. jejuni group antigens by enzyme-linked immunosorbent assay were markedly impaired in the three patients with persistent infection compared with forty-two immunocompetent C. jejuni-infected controls and with the HIV-infected patient who readily cleared the organism. One patient was bacteremic; his blood isolate was killed by normal serum but was resistant to his own serum, whereas a simultaneous stool isolate of a different serotype was sensitive. Failure of two patients to eradicate the organism and long-term administration of erythromycin therapy led to the in-vivo development of resistance to this antibiotic, which is most frequently used to treat C. jejuni infections.
A combination of the aldose reductase inhibitor, statil, and the prostaglandin E1 analogue, OP1206.αCD, completely improves sciatic motor nerve conduction velocity in streptozocin-induced chronically diabetic rats
Authors: Hitoshi Yasuda, Masanobu Sonobe, Takashi Hisanaga, Toru Kawabata, Kengo Maeda, Ryuichi Kikkawa, Yukio Shigeta
Journal: Metabolism (1992)
Development of a murine model for blastoid variant mantle-cell lymphoma
Authors: Richard J. Ford, Long Shen, Yen Chiu Lin-Lee, Lan V. Pham, Asha Multani, Hai-Jun Zhou, Archito T. Tamayo, ChongJie Zhang, Lesleyann Hawthorn, John K. Cowell, Julian L. Ambrus
Journal: Blood (2007)
The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
Authors: Andreas Rosenwald, George Wright, Adrian Wiestner, Wing C Chan, Joseph M Connors, Elias Campo, Randy D Gascoyne, Thomas M Grogan, H.Konrad Muller-Hermelink, Erlend B Smeland, Michael Chiorazzi, Jena M Giltnane, Elaine M Hurt, Hong Zhao, Lauren Averett, Sarah Henrickson, Liming Yang, John Powell, Wyndham H Wilson, Elaine S Jaffe, Richard Simon, Richard D Klausner, Emilio Montserrat, Francesc Bosch, Timothy C Greiner, Dennis D Weisenburger, Warren G Sanger, Bhavana J Dave, James C Lynch, Julie Vose, James O Armitage, Richard I Fisher, Thomas P Miller, Michael LeBlanc, German Ott, Stein Kvaloy, Harald Holte, Jan Delabie, Louis M Staudt
Journal: Cancer Cell (2003)
A PATIENT WHO CHANGED MY PRACTICE
Authors: A. Thorns
Journal: BMJ (1996)

It was my first house job. Surgery. I was fresh out of medical school and enthusiastic, a keen but naive young doctor. Fred—we were not allowed to call her anything else—was in her 70s and came from the north east. Admitted under us with abdominal pain, she was soon found to have a large and advanced lung primary.

The prognosis was gloomy. She was awaiting a hospice bed and stayed with us on the ward for a couple …
Mental Health Care Lacking
Authors: Bridget M. Kuehn
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1126 THE STAGE OF DISEASE INFLUENCES THE HBX-SPECIFIC IMMUNE RESPONSE IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION: A CROSS SECTIONAL ANALYSIS
Authors: L. Testa, E. Loggi, C. Cursara, S. Lorenzini, C. Granieri, R. Di Donato, C. Brander, M. Bernardi, P. Andreone
Journal: Journal of Hepatology (2011)
Uric acid: a risk factor for coronary heart disease?
Authors: V W Persky, A R Dyer, E Idris-Soven, J Stamler, R B Shekelle, J A Schoenberger, D M Berkson, H A Lindberg
Journal: Circulation (1979)

The association between serum uric acid and the prevalence of ECG abnormalities was analyzed for 24.997 employed men and women, white and black, age 18--64 years, from the Chicago Heart Association (CHA) Detection Project in Industry. In addition, the relationships between uric acid and 5-year mortality from all causes, from cardiovascular diseases (CVD), and from coronary heart disease (CHD) were analyzed for 7804 white men and women age 45--64 years from this study and 967 white men age 44--63 years from the Chicago People's Gas Company Study. For men, the association between uric acid and the prevalence of ECG abnormalities and with mortality appear to be secondary to associations between uric acid and other risk factors. For women, however, the associations could not be explained by other risk factors.
Harm reduction measures and injecting inside prison versus mandatory drugs testing: results of a cross sectional anonymous questionnaire survey
Authors: A G. Bird, S. M Gore, S. J Hutchinson, S. C Lewis, S. Cameron, S. Burns
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objectives:</b> (<i>a</i>) To determine both the frequency of injecting inside prison and use of sterilising tablets to clean needles in the previous four weeks; (<i>b</i>) to assess the efficiency of random mandatory drugs testing at detecting prisoners who inject heroin inside prison; (<i>c</i>) to determine the percentage of prisoners who had been offered vaccination against hepatitis B. <b>Design:</b> Cross sectional willing anonymous salivary HIV surveillance linked to a self completion risk factor questionnaire. <b>Setting:</b> Lowmoss prison, Glasgow, and Aberdeen prison on 11 and 30 October 1996. <b>Subjects:</b> 293 (94%) of all 312 inmates at Lowmoss and 146 (93%) of all 157 at Aberdeen, resulting in 286 and 143 valid questionnaires. <b>Main outcome measures:</b> Frequency of injecting inside prison in the previous four weeks by injector inmates who had been in prison for at least four weeks. <b>Results:</b> 116 (41%) Lowmoss and 53 (37%) Aberdeen prisoners had a history of injecting drug use but only 4% of inmates (17/395; 95% confidence interval 2% to 6%) had ever been offered vaccination against hepatitis B. 42 Lowmoss prisoners (estimated 207 injections and 258 uses of sterilising tablets) and 31 Aberdeen prisoners (229 injections, 221 uses) had injected inside prison in the previous four weeks. The prisons together held 112 injector inmates who had been in prison for more than four weeks, of whom 57 (51%; 42% to 60%) had injected in prison in the past four weeks; their estimated mean number of injections was 6.0 (SD 5.7). Prisoners injecting heroin six times in four weeks will test positive in random mandatory drugs testing on at most 18 days out of 28. <b>Conclusions:</b> Sterilising tablets and hepatitis B vaccination should be offered to all prisoners. Random mandatory drugs testing seriously underestimates injector inmates9 harm reduction needs. <h3>Key messages</h3> Half of injector inmates of two Scottish prisons who had been in prison for more than four weeks had injected in the previous four weeks—an average of six times Injector inmates used sterilising tablets to clean injecting equipment as often as they injected Only 4% of inmates had ever been offered vaccination against hepatitis B Vaccination against hepatitis B and sterilising tablets are prisoners9 rights Random mandatory drugs testing is likely to detect only one third to two thirds of heroin injectors in prison and so seriously underestimates injector inmates9 drug reduction needs
Sphincter of Oddi and Filling of the Gallbladder - A Necropsy Study (Endoscopy 21 (1989) 131)
Authors: H. von Sanden, W. Schmitt, R. Ottenjann
Journal: Endoscopy (1989)

See also: Sphincter of Oddi and Filling of the Gallbladder A Necropsy StudyEndoscopy 1989; 21(03): 131-132DOI: 10.1055/s-2007-1012921
Effect of Insulin Therapy on Blood Pressure in NIDDM Patients With Secondary Failure
Authors: Hoosen A Randeree, Mahomed A K Omar, Ayesha A Motala, Mohomed A Seedat
Journal: Diabetes Care (1992)

To assess the effect of insulin therapy on blood pressure in NIDDM patients with secondary failure.The influence of insulin treatment on blood pressure was assessed retrospectively in a group of 80 NIDDM patients with secondary failure to diet and maximum doses of oral hypoglycemic agents. Weight, blood glucose, and blood pressure were recorded over a 3-mo period before and after the initiation of insulin therapy.There was a significant rise in systolic (131.8 +/- 1.7 to 148 +/- 1.9 mmHg, P less than 0.05) and diastolic (80.9 +/- 0.9 to 89.2 +/- 1.0 mmHg, P less than 0.02) blood pressures with insulin treatment. Insulin treatment was associated with a significant decrease in blood glucose (18.36 +/- 0.28 to 10.4 +/- 0.34 mM, P less than 0.01) and an increase in weight (72.1 +/- 1.6 to 78 +/- 1.7 kg, P = 0.01). A control group of 80 NIDDM patients matched for age, weight, BMI, and duration of diabetes demonstrated no significant change in blood pressure over a matched period of follow-up.This study has shown that insulin therapy is associated with significant elevation of both systolic and diastolic blood pressures.
Rheumatoid arthritis with rheumatoid heart disease and granulomatous aortitis
Authors: K. A. Reimer
Journal: JAMA (1976)

Aortic insufficiency and aortitis are frequent complications of ankylosing spondylitis but are considered rare in rheumatoid arthritis. A 49-year-old woman with severe rheumatoid arthritis had the cardiovascular changes common to both diseases. At autopsy, the heart and aorta showed granulomatous ane fibrinous pericarditis and epicarditis, "core" granulomas in the aortic valve cusps and mitral valve leaflets, and coronary arteritis. These are considered to be classical changes of rheumatoid carditis. In addition, there were mesoaortitis with obliterative endarteritis of the vasa vasorum and fibrosis of the aortic cusps with separation of the commissures. These are considered to be changes of ankylosing spondylitis. This case, therefore, represents a mixed form of cardiovascular involvement within the spectrum of the rheumatoid diseases.
Combination of Bevacizumab and Docetaxel in Docetaxel-Pretreated Hormone-Refractory Prostate Cancer: A Phase 2 Study
Authors: Giuseppe Di Lorenzo, William D. Figg, Sophie D. Fossa, Vincenzo Mirone, Riccardo Autorino, Nicola Longo, Ciro Imbimbo, Sisto Perdonà, Antonio Giordano, Mario Giuliano, Roberto Labianca, Sabino De Placido
Journal: European Urology (2008)
ACUTE ABSCESS OF THE THROAT IN CHILDHOOD
Authors: WILLIAM DEERING
Journal: JAMA (1942)

This report deals with 250 cases of true and potential, or abortive, abscesses in the throats of children under 14 years of age observed in the wards of the Children's Memorial Hospital, Chicago, over a period of ten years ended Dec. 31, 1940. In 181 of these cases there was frank suppuration, as shown by spontaneous rupture or surgical drainage. In the remaining 69 a localized inflammatory lesion, apparently differing in no way from the lesions in the early stages of the other group, subsided without evident pus formation for one reason or another. Nearly all of these cases were treated in the pediatric service exclusively except when laryngologic help seemed indicated as in any analogous situation. This rather unusual procedure requires some justification, at least an explanation.  At the Children's Memorial Hospital, except for one resident in pathology, all the house staff are future pediatricians or general practitioners and
Relation of Plasma to Interstitial Fluid Volume in Essential Hypertension
Authors: ROBERT C. TARAZI, HARRIET P. DUSTAN, EDWARD D. FROHLICH
Journal: Circulation (1969)

Extracellular water (radiobromine), plasma volume (radioiodinated human serum albumin), and peripheral plasma renin activity were measured simultaneously in men with uncomplicated, untreated essential hypertension and in normal subjects. The ratio of plasma volume to interstitial fluid volume (PV/IF) was significantly lower in hypertensive patients (0.194 vs. 0.223, P &lt;0.001). This could not be explained only on the basis of the diminished plasma volume found in hypertensive patients (17.3 ml/cm of body height vs. 18.7 ml/cm, P &lt;0.05), as three normal subjects with marked plasma volume contraction had normal PV/IF ratios (0.224). This disturbed ratio in hypertensives suggests, therefore, an abnormality in the mechanism regulating the distribution of extracellular water in essential hypertension. Peripheral plasma renin activity correlated inversely with plasma volume, but not with extracellular water volume, suggesting that these two indices of body fluid volume are not always functionally interchangeable.
Plasmin induces degradation and dysfunction of laminin 332 (laminin 5) and impaired assembly of basement membrane at the dermal–epidermal junction
Authors: Y. Ogura, Y. Matsunaga, T. Nishiyama, S. Amano
Journal: British Journal of Dermatology (2008)

The epidermal basement membrane (BM), located at the dermal-epidermal junction (DEJ), plays important roles not only in adhesion between epidermis and dermis, but also in controlling skin functions. In sun-exposed skin, the BM becomes disrupted and multilayered. In order to explore the impairment of BM assembly, we have used a skin-equivalent (SE) as a model of BM damage and previously clarified the involvement of matrix metalloproteinases (MMPs) in impairment of BM assembly.In this work, we examined the role of urokinase-type plasminogen activator (uPA) and plasmin in impairment of BM assembly at the DEJ by using the SE, as ultraviolet irradiation to the skin increases uPA as well as MMPs.SEs were used as a model of formation and damage of BM. Human uPA was detected by enzyme-linked immunosorbent assay and zymography, and gelatinases such as MMP-2 and MMP-9 were detected by zymography. Human plasminogen was added at 0.06 micromol L(-1) (about 3% of plasma level) to increase plasmin to a pathological level. N-terminal peptide sequence analysis of plasmin-treated laminin 332 was carried out to identify alpha3, beta3 and gamma2 chains of laminin 332 and their cleavage sites of each chain. Plasmin-treated laminin 332 was analysed in keratinocyte adhesion activity and binding to type VII collagen.Human uPA was detected in addition to MMP-2 and MMP-9, in conditioned medium of SE. Although the BM was well organized in the presence of an MMP inhibitor alone, the activated plasmin disorganized the BM even in the presence of the inhibitor. The impairment of BM assembly made the epidermis thinner as compared with that of a control cultured in the presence of MMP inhibitor, indicating that the BM affects the polarity and differentiation of the epidermis. The addition of aprotinin, a serine proteinase inhibitor, and tranexamic acid, a uPA-plasmin inhibitor, inhibited the plasmin-induced impairment of BM assembly and facilitated BM reorganization, thereby improving the epidermal structure. N-terminal peptide sequence analysis of plasmin-treated laminin 332 revealed the removal of a 5- or 10-kDa fragment, including the cell adhesion region, from the G3 domain of the alpha3 chain, and the LN domain, which binds to the noncollagenous 1 domain in type VII collagen, from the beta3 chain. Plasmin-treated laminin 332 showed lower keratinocyte adhesion activity and reduced binding to type VII collagen.These results suggest that uPA and plasmin are involved in the impairment of BM assembly and epidermal differentiation, and that these effects arise at least partly through direct degradation of laminin 332.
Protease inhibitors protect growth factor activity in chronic wounds
Authors: M. Wlaschek, D. Peus, V. Achterberg, W. Meyer-Ingold, K. Scharffetter-Kochanek
Journal: British Journal of Dermatology (1997)

Journal Article Protease inhibitors protect growth factor activity in chronic wounds Get access M. Wlaschek, M. Wlaschek Department of Dermatology, University of Cologne, 50924 Cologne, Germany Search for other works by this author on: Oxford Academic Google Scholar D. Peus, D. Peus Department of Dermatology, University of Cologne, 50924 Cologne, Germany Search for other works by this author on: Oxford Academic Google Scholar V. Achterberg, V. Achterberg Beiersdorf AG, 20245 Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar W. Meyer‐Ingold, W. Meyer‐Ingold Beiersdorf AG, 20245 Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar K. Scharffetter‐Kochanek K. Scharffetter‐Kochanek Department of Dermatology, University of Cologne, 50924 Cologne, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 4, 1 October 1997, Pages 646–663, https://doi.org/10.1111/j.1365-2133.1997.tb03804.x Published: 01 October 1997
Clinical Lecture as Lateral Curvature of the Spine
Authors: C. Heath
Journal: BMJ (1878)

in' males, and particulair that the upper ribs move much, more freely, YY~~~~TTI~~~~~AY ~~~the.breasts of women rising -andl failing with each respiration in a way CLINICALLECTURE ~~~~~never seen in mn.Now the important inspiratory muscle, the serratus ON magnus, takes its -fixed point from the scapula and is inserted into the LATERAL CURVATUREO O upper ribs, and must draw them -upwards and backwards equailly in LATERAL CURVATURE OF THE SPINE.~health, but to one side miore than the other, if from any cause-the Delivred t Unversty ColegeHosptal.muscles are unequally developed, or if, as shown to you by Dr. Sayre last year, the pressure of the head and thorax upon a weakly sup- By CHRISTOPHER HEATH, -F.R.C.s.Eng., ported spine tends directly to produce a-rotation of the vertebrae.Un-
Full Disclosure — Out-of-Pocket Costs as Side Effects
Authors: Peter A. Ubel, Amy P. Abernethy, S. Yousuf Zafar
Journal: New England Journal of Medicine (2013)

Interview with Dr. Peter Ubel on a new focus on informing patients about the likely out-of-pocket costs of care. (07:30)Download Because treatments can impose out-of-pocket costs that may impair patients' well-being, physicians should disclose the financial consequences of treatment alternatives just as they inform patients about treatments' side effects.
Remodelling of left ventricle after banding of ascending aorta in the rat
Authors: M. Imamura, M. Schluchter, F. M Fouad-Tarazi
Journal: Cardiovascular Research (1990)

Journal Article Remodelling of left ventricle after banding of ascending aorta in the rat Get access Mitsuhide Imamura, Mitsuhide Imamura Correspondence to: Dr Fouad-Tarazi Search for other works by this author on: Oxford Academic PubMed Google Scholar Mark Schluchter, Mark Schluchter Search for other works by this author on: Oxford Academic PubMed Google Scholar Fetnat M Fouad-Tarazi Fetnat M Fouad-Tarazi Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 8, August 1990, Pages 641–646, https://doi.org/10.1093/cvr/24.8.641 Published: 01 August 1990 Article history Received: 16 October 1989 Accepted: 19 February 1990 Published: 01 August 1990