Insulin-Dependent Diabetes Mellitus Associated with Parvovirus B19 Infection
Authors: Akira Kasuga
Journal: Annals of Internal Medicine (1996)

Letters15 October 1996Insulin-Dependent Diabetes Mellitus Associated with Parvovirus B19 InfectionAkira Kasuga, MD, Reiko Harada, MD, and Takao Saruta, MDAkira Kasuga, MDTokyo Denryoku Hospital, Tokyo, JapanKeio University School of Medicine, Tokyo, Japan, Reiko Harada, MDTokyo Denryoku Hospital, Tokyo, JapanKeio University School of Medicine, Tokyo, Japan, and Takao Saruta, MDTokyo Denryoku Hospital, Tokyo, JapanKeio University School of Medicine, Tokyo, JapanAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-8-199610150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Viruses may play a role in the pathogenesis of insulin-dependent diabetes mellitus (IDDM) [1]. Coxsackievirus P2-C shares homologous sequences with glutamic acid decarboxylase, an autoantigen for IDDM; it has been suggested that this mimicry may trigger autoimmunity. We report a case of IDDM associated with infection with parvovirus B19, which shares homologous sequences with IA-2, another autoantigen for IDDM.A 21-year-old man developed IDDM after experiencing flu-like symptoms. He subsequently developed a lacy, reticular, erythematous rash that worsened with changes in environmental temperature. These findings are typical of erythema infectiosum. Laboratory findings showed abrupt onset of IDDM, ...References1. Eisenbarth GS, Ziegler AG, Colman PA. Pathogenesis of insulin-dependent diabetes mellitus. In: Kahn CR, Weir GC, eds. Joslin's Diabetes Mellitus. Malvern, PA: Lea & Febiger; 1994:216-39. Google Scholar2. Lan MS, Lu J, Goto Y, Notkins AL. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biology. 1994; 13:505-14. Google Scholar3. Shade RO, Blundell MC, Cotmore SF, Tattersall P, Astell CR. Nucleotide sequence and genome organization of human parvovirus B19 isolated from the serum of a child during aplastic crisis. J Virol. 1985; 58:921-36. Google Scholar Author, Article, and Disclosure InformationAffiliations: Tokyo Denryoku Hospital, Tokyo, JapanKeio University School of Medicine, Tokyo, Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByViruses and Type 1 Diabetes: From Enteroviruses to the ViromeMicrobiome and Cellular Players in Type 1 Diabetes: From Pathogenesis to ProtectionAdeno-associated virus neutralising antibodies in type 1 diabetes mellitusIntestinal virome changes precede autoimmunity in type I diabetes-susceptible childrenHuman ParvovirusesThe role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune diseaseType 1 Diabetes: Etiology, Immunology, and Therapeutic StrategiesHuman parvovirus B19 infection in children with new onset Type 1 diabetes mellitusRheumatoid arthritis, type 1 diabetes, and Graves' disease after acute parvovirus B19 infectionCytokines in parvovirus b19 infection as an aid to understanding chronic fatigue syndrome 15 October 1996Volume 125, Issue 8Page: 700-701KeywordsAutoantigenAutoimmunityDiabetes mellitusHemoglobinInsulinPathogenesisRashesResearch laboratoriesTemperatureVesicles Issue Published: 15 October 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...