Hemorrhagic and Interstitial Pneumonitis with Nephritis
Authors: IRVING L. LEFF
Journal: Annals of Internal Medicine (1962)

Case Reports1 February 1962Hemorrhagic and Interstitial Pneumonitis with NephritisIRVING L. LEFF, M.D., GEORGE FAZEKAS, M.D.IRVING L. LEFF, M.D.Search for more papers by this author, GEORGE FAZEKAS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-296 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1955 Parkin and others (1) reported a group of cases of hemorrhagic and interstitial pneumonitis with nephritis whose pathogenesis was thought to involve a hypersensitivity reaction. In some, penicillin was suspected as the offending allergen.The role of allergy in the production of fulminating visceral and vascular disease, first suggested early in this century (2), has received considerable attention in recent years with much speculation whether local Arthus phenomena or altered reactivity might account for such entities as Loeffler's syndrome, Wegener's granulomatosis, and polyarteritis nodosa (3). The possibility that drugs could be involved in the pathogenesis of the latter...References1. PARKINRUSTEDBURCHELLEDWARDS TWIEHBJE: Hemorrhagic and interstitial pneumonitis with nephritis. Amer. J. Med. 18: 220, 1955. CrossrefMedlineGoogle Scholar2. SCHICK B: Die Nachkrankheiten der Scharlach. Jahrb. Kinderheilk. 65: 132, 1907. Google Scholar3. FIENBERG RA. : Necrotizing granulomatosis and angiitis of the lungs and its relationship to chronic pneumonitis of the cholesterol type. Amer. J. Path. 29: 913, 1953. B. MCCOMBS, R. P., PATTERSON, J. F., MACMAHON, H. E.: Syndromes associated with "allergic" vasculitis. New Engl. J. Med. 255: 251, 1956. MedlineGoogle Scholar4. RICH ARA. : The role of hypersensitivity in periarteritis nodosa as indicated by 7 cases developing during serum sickness and sulfonamide therapy. Bull. Johns Hopkins Hosp. 71: 123, 1942. B. RICH, A. R.: Additional evidence of the role of hypersensitivity in the etiology of periarteritis nodosa; another case associated with sulfonamide reaction. Bull. Johns Hopkins Hosp. 71: 375, 1942. C. RICH, A. R., GREGORY, J. E.: The experimental demonstration that periarteritis nodosa is a manifestation of hypersensitivity. Bull. Johns Hopkins Hosp. 72: 65, 1943. Google Scholar5. RICH AR: Pathology and pathogenesis of experimental anaphylactic glomerulonephritis in relation to human acute glomerulonephritis. Bull. Johns Hopkins Hosp. 98: 120, 1956. MedlineGoogle Scholar6. MCLETCHIEMACDONALDCUTTS NGRMJH: Polyarteritis nodosa; report of a case with proof of drug allergy. Canad. Med. Ass. J. 76: 213, 1957. MedlineGoogle Scholar7. MELLORSORTEGA RCLG: Analytical pathology; new observations on pathogenesis of glomerulonephritis, lipid nephrosis, periarteritis nodosa, and secondary amyloidosis in man. Amer. J. Path. 32: 455, 1956. MedlineGoogle Scholar8. FIENBERG R: Pathergic granulomatosis. Amer. J. Med. 19: 829, 1955. CrossrefMedlineGoogle Scholar9. BLANKENHORNKNOWLES MAHC: Periarteritis nodosa: recognition and clinical symptoms. Ann. Intern. Med. 41: 887, 1954. LinkGoogle Scholar10. HARKAVY J: Vascular allergy. J. Allergy 14: 507, 1943. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Buffalo, New YorkFrom the Medical and Laboratory Services of the Buffalo Veterans Administration Hospital, and the Department of Medicine, University of Buffalo School of Medicine, Buffalo, New York.Requests for reprints should be addressed to Irving L. Leff, M.D., Section on General Medicine, Veterans Administration Hospital, 3495 Bailey Avenue, Buffalo 15, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGoodpasture's syndrome with normal renal functionRemission in Goodpasture's syndrome: report of two patients treated by immunosuppression and review of the literatureGoodpasture's syndromeGLOMERULONEPHRITIS WITH INITIAL LUNG PURPURA (GOODPASTURE'S SYNDROME)Pulmonary Haemorrhage in Renal DiseaseKasuistischer Beitrag zum Goodpasture-SyndromLung Purpura and Nephritis (Goodpasture's Syndrome) Complicated by the Nephrotic SyndromeV. R. BLOOM, B.M., D. J. WAYNE, B.M., O. M. WRONG, D.M.Pulmonary Hemorrhage and Glomerulonephritis Report of Six Cases and Study of the Renal Lesion by the Fluorescent Antibody Technique and Electron MicroscopyDONALD A. DUNCAN, M.D., KEITH N. DRUMMOND, M.D., ALFRED F. MICHAEL, M.D., ROBERT L. VERNIER, M.D.Idiopathic Pulmonary Hemosiderosis and GlomerulonephritisSURVIVAL AFTER HÆMOPTYSIS AND NEPHRITISTHE MENTAL NURSE IN THE COMMUNITYTHE LUNGS IN KYPHOSCOLIOSISNEPHRITIS WITH LUNG HÆMORRHAGE 1 February 1962Volume 56, Issue 2Page: 296-302KeywordsFibrosisHemorrhageHospital medicineInterstitial lung diseasesNephritisPathogenesisPneumonitisResearch laboratoriesVascular diseasesWegener granulomatosis Issue Published: 1 February 1962 PDF DownloadLoading ...