tbuckley/cabot-search huggingface dataset:
Abstract B3: CD24 affects tumor cell properties and cytokine secretion in a STAT3-dependent fashion
Authors: Niko P. Bretz, Alexei V. Salnikov, Gerhard Moldenhauer, Peter Altevogt
Journal: Cancer Research (2013)

Abstract CD24 is a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein frequently over-expressed in human carcinomas and associated with metastasis and poor prognosis. Previous work has shown that CD24 expression affects various cellular properties such as invasion, adhesion, proliferation and apoptosis in vitro as well as tumor growth in vivo. By analyzing underlying mechanisms of CD24-dependent tumor cell behaviour we discovered the influence of CD24 on STAT3 signaling and gene regulation via the tyrosine kinase c-Src. Altered activity of c-Src mediated by CD24 knock-down was responsible for reduced levels of phosphorylated STAT3 (Y705). Diminished activity of STAT3 was confirmed by luciferase-reporter assays. Silencing of c-Src, similar to CD24, reduced the expression of prototype STAT3-regulated genes. Likewise, the over-expression of CD24 augmented c-Src activity, the recruitment of c-Src into lipid rafts, levels of p-STAT3 and the expression of STAT3-dependent target genes. Functionally, depletion of CD24 reduced cell proliferation and increased apoptosis, suggesting a pivotal role of regulated target genes for these functional effects. Even more profoundly, CD24 expression was accompanied with the secretion of the STAT3 target IL-6. We could show a strong correlation between IL-6 secretion and CD24 expression in tumor cell lines. Furthermore, treatment with conditioned cell culture medium from CD24 over-expressing- or CD24 knock-down tumor cells initiated paracrine STAT3 signaling and gene regulation in the monocytic precursor cell line THP-1. This suggested a regulative role of CD24 on the tumor microenvironment. We propose that CD24 is capable of influencing not only tumor cellular properties but also has impact on the cytokine milieu of the tumor microenvironment. Citation Format: Niko P. Bretz, Alexei V. Salnikov, Gerhard Moldenhauer, Peter Altevogt. CD24 affects tumor cell properties and cytokine secretion in a STAT3-dependent fashion. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr B3.
Interobserver agreement on classifying endoscopic diagnoses of nonerosive esophagitis
Authors: Y. Amano, N. Ishimura, K. Furuta, K. Okita, M. Masaharu, T. Azumi, T. Ose, K. Koshino, S. Ishihara, K. Adachi, Y. Kinoshita
Journal: Endoscopy (2006)

The majority of patients with gastroesophageal reflux disease in Japan have low-grade esophagitis, including minimal changes. A modified Los Angeles classification of esophagitis, consisting of erosive esophagitis (grades A - D) and nonerosive esophagitis (grades M and N) has been proposed and is in clinical use in Japan. However, it is unclear whether nonerosive esophagitis with only undemarcated mucosal discoloration (grade M) is clinically significant, since interobserver variations in classification have not been investigated. The aim of the present study was therefore to evaluate interobserver variance and diagnostic agreement in the diagnosis of nonerosive esophagitis (grades M and N).A total of 84 endoscopists were enrolled to assess the grade of esophagitis in 30 patients by viewing endoscopic images of the gastroesophageal junction. The images were projected onto a screen, and all of the endoscopists reviewed them concurrently. The diagnosis was selected from the following three categories in the modified Los Angeles classification: grades N, M, or A. The endoscopists were grouped according to their experience, whether they had a board license, and whether they had received specialist training in esophagitis. The kappa coefficient of reliability was calculated.The kappa coefficient of reliability for all the endoscopists in the diagnosis of cases of grade M and N nonerosive esophagitis was unacceptably low at 0.22 (95 % CI, 0.21 - 0.24). Endoscopists with a board license and those who had completed a special esophagitis diagnostic course had slightly higher kappa values (0.26; 95 % CI, 0.23 - 0.30 and 0.29; 95 % CI, 0.26 - 0.32), respectively.Interobserver agreement on the endoscopic diagnosis of nonerosive esophagitis (grades M and N) is too low to be of clinical value.
Infantile seborrhoeic dermatitis
Authors: C.F.H. Vickers
Journal: British Journal of Dermatology (1983)

Journal Article Infantile seborrhoeic dermatitis Get access C.F.H. Vickers C.F.H. Vickers Dept. of Dermatology, Royal Liverpool Hospital, Liverpool L69 3BX Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 109, Issue 6, 1 December 1983, Page 722, https://doi.org/10.1111/j.1365-2133.1983.tb00557.x Published: 01 December 1983
Stress reactivity to and recovery from a standardised exercise bout: a study of 31 runners practising relaxation techniques
Authors: E E Solberg, F Ingjer, A Holen, J Sundgot-Borgen, S Nilsson, I Holme
Journal: British Journal of Sports Medicine (2000)

Objective —To compare the efficacy in runners of two relaxation techniques with regard to exercise reactivity and recovery after exercise. Methods —Thirty one adult male runners were studied prospectively for six months in three groups practising either meditation (n = 11) or autogenic training (n = 11) or serving as controls (n = 10). Before and after the six months relaxation intervention, indicators of reactivity to exercise and metabolism after exercise (blood lactate concentration, heart rate (HR), and oxygen consumption (V o 2 )), were tested immediately after and 10 minutes after exercise. Resting HR was also assessed weekly at home during the trial. State anxiety was measured before and after the intervention. Results —After the relaxation training, blood lactate concentration after exercise was significantly (p&lt;0.01) decreased in the meditation group compared with the control group. No difference was observed in lactate responses between the autogenic training group and the control group. There were no significant differences among the groups with regard to HR, V o 2 , or levels of anxiety. Conclusion —Meditation training may reduce the lactate response to a standardised exercise bout.
Diagnostic Value of Echocardiography in Suspected Endocarditis
Authors: Jonathan R. Lindner, R. Alex Case, John M. Dent, Robert D. Abbott, W. Michael Scheld, Sanjiv Kaul
Journal: Circulation (1996)

Background We hypothesized that for the diagnosis of endocarditis, (1) transthoracic echocardiography (TTE) would be most valuable in patients with an intermediate clinical probability of the disease and (2) transesophageal echocardiography (TEE) would be most useful in patients with an intermediate probability when TTE either does not yield an adequate study or indicates an intermediate probability of endocarditis. We also sought to investigate the influence of echocardiographic results on antibiotic usage and its duration. Methods and Results TTE and TEE were performed in 105 consecutive patients with suspected endocarditis. Patients were classified as having either low, intermediate, or high probability of endocarditis on the basis of clinical criteria and separately on the basis of both TTE and TEE findings. TTE and TEE classified the majority (82% and 85%, respectively) of the 67 patients with a low clinical probability of endocarditis as having a low likelihood of the disease. Of the 14 patients with intermediate clinical probability, 12 had technically adequate TTE studies; 10 of these (83%) were classified as either high or low probability. All patients with intermediate clinical probability were classified as high or low probability by TEE. The majority of the 24 patients with high clinical probability were placed in the low-likelihood category by echocardiography (15 by TTE and 12 by TEE). There was concordance between TTE and TEE in 83% of all cases. TEE was useful for the diagnosis of endocarditis in patients with prosthetic valves and in those in whom TTE indicated an intermediate probability; these constituted &lt;20% of patients in our study. The course of antibiotic therapy was influenced only by the clinical profile and not by the echocardiographic results. Conclusions Echocardiography should not be used to make a diagnosis of endocarditis in those with a low clinical probability of the disease. In those with an intermediate or high clinical probability, TTE should be the diagnostic procedure of choice. TEE for the diagnosis of endocarditis should be reserved only for patients who have prosthetic valves and in whom TTE is either technically inadequate or indicates an intermediate probability of endocarditis.
Abstract P1-15-03: Preoperative endocrine treatment with letrozole ± triptorelin in patients with ER (estrogen receptor) and PgR (progesterone receptor) positive locally advanced breast cancer
Authors: M Mazza, A Luini, P Veronesi, M Intra, V Bagnardi, F Sangalli, M Iorfida, E Munzone, M Colleoni
Journal: Cancer Research (2013)

Abstract Background: Neoadjuvant endocrine therapy demonstrated activity in endocrine responsive locally advanced breast cancer. Proper duration of neoadjuvant therapy has not yet established. We aimed to assess the efficacy and safety of longer duration of letrozole alone or combined with triptorelin in pre-or postmenopausal breast cancer patients. Methods: Premenopausal and postmenopausal patients (pts) with ER and PgR-positive &amp;gt; 50% of the cells, HER2-negative, T2-T4b breast cancer were considered eligible. Patients received letrozole 2,5 mg per day (plus triptorelin 3,75 mg/month in premenopausal pts) for 3-9 months. Tumor response was measured by caliper, ultrasound (US) and mammography. The primary endpoint was overall tumour response (ORR) (complete response plus partial response), during the neoadjuvant treatment period for the intention-to-treat population. Results: Between 2009 and 2013, 54 pts were enrolled and 46 (34 pre- and 12 post-menopausal) pts were evaluable for ORR. Median age was 44 and 55 years, respectively. 44 patients are evaluable. The ORR was 77% in the premenopausal group and 67% in the postmenopausal group. One premenopausal patient had a pathological complete response (pCR). The mean time to complete/partial response was 4.9 months (95% CI: 3.8-6.0) in the premenopausal group and 3.6 months (95% CI: 0.8-6.4) in the postmenopausal group. Overall, 56% of premenopausal and 58% of postmenopausal pts underwent breast conservative surgery. Ki67-LI after surgery had a mean decrease of 33% (95% CI: 16%-50%, p-value = 0.0005) and 42% (95% CI: 18%-65%, p-value = 0.0030) in pre-and postmenopausal pts, respectively. Therapy was well tolerated in both groups with no grade 3/4 toxicity. The most common adverse events in both groups were hot flashes, fatigue, arthralgias/stiffness, and myalgias. Conclusions: The results of this preliminary analysis support neoadjuvant endocrine therapy for a duration of up to 9 months. The combination of letrozole plus triptorelin might represent an alternative neoadjuvant treatment option for premenopausal women with early stage endocrine-responsive breast cancer. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-15-03.
Of 'War Bread' and Toadstools: Questions You Have Asked
Authors: Helene M. Cole
Journal: JAMA (1985)

What do mushrooms in suburbia,<sup>1</sup>the formula for "war bread,"<sup>2</sup>apiotherapy,<sup>3</sup>and "coffee anemia"<sup>4</sup>have in common? All, surprisingly, have been among the thousands of topics addressed in the QUESTIONS AND ANSWERS column ofThe Journal. Since the column began in September 1902 as QUERIES AND MINOR NOTES, it has regularly served physicians both in the United States and overseas as a source of information on myriad topics. Such international interest is evidenced by the inquiries we receive from physicians around the globe, and the regular publication of excerpts from the QUESTIONS AND ANSWERS section in several of the foreign language editions ofThe Journal. In taking on my new duties as editor of the column, I have had the opportunity to review some of the history and to reflect upon the goals and intent of the column. Remarkably few changes have been made over the
Biopsy of Malignant Melanoma
Authors: Lynn G. Cranmer
Journal: JAMA (1978)

To the Editor.—  The question by Solomon Garb, MD, of Denver is answered by an anesthesiologist, John Adriani, MD (238:1851, 1977), and leaves one to think that the injection of a local anesthetic for excision or incisional biopsy of a malignant lesion could theoretically cause the spread of malignant melanoma cells. There have been several good studies to indicate that incisional biopsies do not in any way change the overall prognosis of patients with malignant melanomas.  To infer that general anesthetic or regional block anesthetic is the correct procedure to use for biopsy of malignant lesions would certainly tend to decrease the number of early biopsies being done, and this more than anything else will tend to prevent the early diagnosis of stage I and stage II malignant melanomas when they are in a most curative stage.
What the Dead Can Teach the Living
Authors: Dalane W. Kitzman, Bharathi Upadhya, Sujethra Vasu
Journal: Circulation (2015)

H eart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF.Approximately 90% of new HF cases in older women are HFpEF. 1 Adverse outcomes -exercise intolerance, poor quality of life, frequent hospitalizations, and reduced survival -approach those of HF with reduced EF (HFrEF).In contrast to HFrEF, the prevalence of HFpEF is increasing and its prognosis is worsening. 2Despite the strong public health importance of HFpEF, its pathogenesis is poorly understood.Our lack of understanding of HFpEF and its treatment is punctuated by the fact that 6 large, well-designed, randomized, clinical trials and several smaller ones were all neutral on their primary outcomes.The combination of high prevalence and lack of evidence-based treatments makes HFpEF a highpriority topic for research in cardiovascular disease. Article see p 550A glaring absence among HFpEF studies has been a systematic autopsy-based study.Such studies have become more difficult as autopsy rates have declined with the availability of advanced multimodality imaging and deep-tissue biopsy techniques.Despite the increasing array of modern research techniques, postmortem methods continue to be uniquely valuable because of the ability to perform comprehensive, indepth, detailed examinations of tissues and organs in humans.In this issue of Circulation, Mohammed and colleagues 3 at the Mayo Clinic fill this critical gap with the first autopsy series of HFpEF.From a tissue registry patiently accumulated over a period of 19 years, their multidisciplinary team methodically collected and comprehensively analyzed specimens, medical records, electrocardiograms, and echocardiograms from 255 individuals, including patients with premortem diagnosis of HFpEF (n=124) and HFrEF (n=27), and from age-matched case controls who died of noncardiovascular causes (n=104).Characteristics of the HFpEF patients were relatively similar to community-based reports, including advanced age and a high prevalence of common comorbidities, including hypertension, diabetes mellitus, obesity, and clinical coronary artery disease (CAD).
Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients
Authors: Chrystal U. Louis, Karin Straathof, Catherine M. Bollard, Claudia Gerken, M. Helen Huls, M. Victoria Gresik, Meng-Fen Wu, Heidi L. Weiss, Adrian P. Gee, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop, Stephen Gottschalk
Journal: Blood (2008)
Biomarkers and pediatric environmental health.
Authors: B Lubin, R Lewis
Journal: Environmental Health Perspectives (1995)

It is now possible to identify biochemical and/or cellular changes in humans due to exposure to an environmental toxin. These changes are called biomarkers and are currently used in research studies to identify individuals exposed to specific toxic substances. Advances in the field of biomarker technology may have important implications for the detection, prevention, and treatment of certain diseases in children. This technology may enable physicians to screen children who have no clinically detectable illness for evidence of exposure to specific toxins. Such information could lead to implementation of preventive measures and development of new therapeutic strategies. However, several important issues, including potential adverse consequences resulting from the widespread use of this technology, must be considered prior to its utilization within a clinical setting. Leaders of the pediatric and public health communities should recognize the paucity of scientific data in the pediatric environmental health area, and new approaches to this important aspect of child health should be developed. This article will address several of the issues involved in pediatric environmental health and consider questions that should be answered as the potential for technology transfer becomes a reality.
Broad approach is needed to reduce gun violence, US psychologists say
Authors: M. McCarthy
Journal: BMJ (2013)

In a report issued to mark the first anniversary of the December 2012 Sandy Hook Elementary School shooting that left 20 schoolchildren and six school staff members dead, an expert panel convened by the American Psychological Association calls for a broad approach to tackle gun violence in America and admits that psychological profiling is not successful in identifying people who might commit such crimes.1

“Although many highly publicized shootings have involved persons with serious mental illness, it must be recognized that persons with serious mental illness commit only a small proportion of firearm-related homicides; the problem of gun violence cannot be resolved simply through efforts focused on serious mental illness,” the panel said.

Gun violence in the United States is a complex, multifaceted problem, the panel said, that requires multifaceted solutions, including interventions that focus on child and adolescent development, that consider the social and cultural factors that promote gun violence particularly among men, and that identify people who are likely to engage in gun violence so that effective preventive steps can be taken.

Gun homicide rates in the …
Computers and urinary tract infection.
Authors: A E MacKinnon
Journal: BMJ (1980)

research or anything else, the public will not give their money.And how can a charity raise money without explaining what it does?Fortunately for the medical research charities in this country, many members of the public who give so generously to these activities seem to take a much more balanced view of the role of research into prevention and treatment or cure than that represented in your leading article.
NT‐proBNP: a marker for successful myocardial reperfusion in AMI patients treated with primary percutaneous coronary intervention
Authors: Jaap‐Ronald Blom, Arnoud W.J. van ‘t Hof, Jose P.S. Henriques, J. Hans Geertman, Robbert Slingerland, Jan C.A. Hoorntje
Journal: European Journal of Heart Failure (2004)
ABC of colorectal cancer: The role of clinical genetics in management
Authors: T R P Cole
Journal: BMJ (2000)

Before 1990 the role of inherited factors in the aetiology of adult cancer was relatively poorly understood and aroused little interest among doctors and the public alike—although familial adenomatous polyposis (the autosomal dominant colon cancer syndrome) was an exception in this respect. In the past decade, however, interest has increased markedly. In the West Midlands, for example, familial cancer referrals constituted  1000).



Number of referrals of patients with cancer (except familial adenomatous polyposis) to West Midlands regional clinical genetics service, 1988-98



Despite the estimate that 5-10% of colorectal cancer has an inherited basis, only a small percentage of referred families have mutations in one of the currently identified genes. Furthermore, mutation studies are usually possible only if DNA is available from an affected patient, so molecular investigation will facilitate the management of only a small minority of cases. The remaining referrals must be managed with clinically derived strategies. This article discusses the clinical features and management of dominant colon cancer syndromes and provides referral guidelines and screening protocols for more common familial clusters.



Features of familial adenomatous polyposis: colon with multiple polyps (top) and jaw cysts (bottom)



Genetic counselling for families with a history of cancer requires a full and accurate family history. When possible, histological confirmation of the reported tumours should be obtained. It should then be possible to recognise the specific cancer syndromes. It is important to emphasise to families that however extensive the family history of cancer (unless present on both sides), a person will always have a greater than 50% chance of not developing that particular tumour. This may surprise but greatly reassure many families.

Familial adenomatous polyposis, previously called polyposis coli (or Gardner's syndrome if extra colonic …
Randomised study of six beta-blockers and a thiazide diuretic in essential hypertension
Authors: R G Wilcox
Journal: BMJ (1978)

Atenolol was compared with five other beta-blockers and a thiazide diuretic in a randomised cross-over trial of once-daily treatment of essential hypertension. Atenolol was significantly better at reducing resting and exercise blood pressures at 24 hours than any of the other drugs and had a low incidence of side effects. Both timolol and acebutolol had a significant hypotensive effect at 24 hours and a low incidence of side effects, suggesting that further increases in dosage might be effective and well tolerated. Labetalol proved ineffective when given once daily, and the high incidence of side effects, equalled only by pindolol, would probably prohibit further increases in dosage. Bendrofluazide was equal or superior to all the beta-blockers except atenolol at reducing resting blood pressure, and its cheapness still makes it an agent of first choice in mild or moderate essential hypertension.
Lipid imaging within the normal rat kidney using silver nanoparticles by matrix-assisted laser desorption/ionization mass spectrometry
Authors: Ludovic Muller, Ajay Kailas, Shelley N. Jackson, Aurelie Roux, Damon C. Barbacci, J. Albert Schultz, Carey D. Balaban, Amina S. Woods
Journal: Kidney International (2015)