tbuckley/cabot-search huggingface dataset:
Health care in developing countries.
Authors: J Yudkin
Journal: BMJ (1978)

intracranial metastases is well documented4-8 47-80 O of unselected patients with intracranial metastases may be expected to obtain symptomatic relief with cranial irradiation5-8 and about 120o are still alive and active one year later.These results are obtained without the stress to the patient of a major operation.We hope these details will encourage the general physician to consider irradiation as a palliative measure for patients with cerebral metastases.
A Study in Scarlet
Authors: S. Malik
Journal: BMJ (2010)

Set in the dun coloured London of telegrams and hansom cabs, when the city’s population was half of what it is today, this, the earliest adventure of the crime solving duo Sherlock Holmes and “his dear” Dr Watson, describes the first acquaintance of the legendary pair, their beginnings at 221b Baker Street, and the murder of two Mormon Americans.

The historic meeting takes place in a laboratory at Bart’s Hospital, where, recovering from a shattered scapula and damaged subclavian artery (incurred by a musket bullet in the second Anglo-Afghan war), John H Watson MD, former army surgeon and the …
Induction of ICOS <sup>+</sup> CXCR3 <sup>+</sup> CXCR5 <sup>+</sup> T <sub>H</sub> Cells Correlates with Antibody Responses to Influenza Vaccination
Authors: Salah-Eddine Bentebibel, Santiago Lopez, Gerlinde Obermoser, Nathalie Schmitt, Cynthia Mueller, Carson Harrod, Emilio Flano, Asuncion Mejias, Randy A. Albrecht, Derek Blankenship, Hui Xu, Virginia Pascual, Jacques Banchereau, Adolfo Garcia-Sastre, Anna Karolina Palucka, Octavio Ramilo, Hideki Ueno
Journal: Science Translational Medicine (2013)

A T cell subset that emerges in blood after seasonal influenza vaccinations correlates with the development of protective antibody responses.
TCTAP A-112 Comparison of 12-month Clinical Outcomes of Infrapopliteal Balloon Angioplasty Alone Versus Balloon Angioplasty with Provisional Stenting in Patients with Critical Limb Ischemia
Authors: Sung Il Im, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Yoonjee Park, Akkala Raghavender Goud, Hu Li, Sunki Lee, Ji Bak Kim, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
Parentcare: A Commonsense Guide for Adult Children
Authors: Don Riesenberg
Journal: JAMA (1988)

In developed countries, the life cycle has come full circle: children often must assume responsibility for their aging parents. The over-65 segment of our population is growing disproportionately, and this demographic reality requires "parentcare" of many adult children. Drs Jarvik and Small provide a manual for persons who are helping their parents deal with aging, its illnesses, disruptions, and conflicts. The authors advocate use of their "commonsense checklist," a five-step method for resolving problems in areas ranging from such basics as money and sex to the complex issues of housing and retirement. The checklist is a way of reading one's responses to an aging parent's crotchets, recalling what strategies have failed in the past and why, and negotiating successful compromise. Later sections of the book deal with specific matters of great importance. Especially strong is the discussion of ways to address physical and mental disabilities, as well as what should
Inhibitory activity of loratadine and descarboethoxyloratadine on expression of ICAM‐1 and HLA‐DR by nasal epithelial cells
Authors: A. M. Vignola, L. Crampette, M. Mondain, G. Sauvère, W. Czarlewski, J. Bousquet, A.M. Campbell
Journal: Allergy (1995)

Nasal epithelial cells represent the first barrier against noxious agents and allergens. In allergic rhinitis, these cells are activated and histamine may be involved in this activation. Loratadine and one of its active metabolites, descarboethoxyloratadine, were studied for their ability to reduce the activation of nasal epithelial cells by histamine. Nasal turbinates or polyps were removed during surgery from 19 subjects, and nasal epithelial cells were recovered after enzymatic digestion. The in vitro activation of epithelial cells with histamine using an optimal dose (1 microM) and an optimal time (24 h) of incubation was studied, and the effect of loratadine or descarboethoxyloratadine (10 microM) was investigated. The expression of membrane markers (intercellular adhesion molecule-1 (ICAM-1) and a human leukocyte class II antigen (HLA-DR) was assessed by immunocytochemical analysis using an alkaline-antialkaline phosphatase (APAAP) system. The spontaneous expression of both markers was not significantly different in cells recovered from nasal turbinates or polyps, and there was a highly significant increase in the numbers of cells expressing ICAM-1 and HLA-DR following incubation with histamine. Loratadine or descarboethoxyloratadine significantly blocked these effects. This study shows a new possible antiallergic effect of H1-blockers and suggests that their effects on epithelial cells may be relevant in vivo.
INSECTS AND WAR: IX.--TICKS
Authors: A. E. Shipley
Journal: BMJ (1914)

TiCKs are mites " writ large," and until about the beginningy of this ceentury tlley were regarded %vitli what one muiglht call miiild disgust and regret.Now, however, that tlley lhave been lproved to play a part, anid a very important part, in tlle cdisseminlation of disease, we lhave come to regar(d tllemn, as Calverley said we slhould regard the decalogue, "w with feelings of reverence miiingled with awe."The body of a tick is covered wvith a tough,-smnoothi or crinkled slkin, capable of any am-ount of extension.Until they
Abstract 2466: The tumor suppressor Merlin decreases TGFβ/Smad signaling in metastatic breast cancer cells
Authors: William P. Jackson, Kelly M. Kreitzburg, Shamik Das, Sarah K. Bailey, Brandon J. Metge, Rajeev S. Samant, Lalita R. Shevde-Samant
Journal: Cancer Research (2014)

Abstract Background: Merlin is a tumor suppressor protein encoded by the NF2 gene. Mutations in NF2 have been implicated in neurofibromas, schwannomas, and mesothelioma. While the mutation rate of NF2 is low in breast cancer, our lab has previously demonstrated a loss of the Merlin protein in advanced stage breast cancers. We have shown that the matricellular metastasis-promoting protein osteopontin activates Akt which then marks Merlin for targeted proteasomal degradation. In the context of other cancers, Merlin has been shown to play a role in sensitization to contact inhibition, cell proliferation, inhibiting invasion, and the negative regulation of focal adhesion kinase. Merlin is also an upstream regulator of the Hippo pathway. However, the implications of the loss of Merlin in the context of breast cancer signaling pathways that promote tumor progression and metastasis have not been fully explored. Here we demonstrate a Merlin-dependent decrease in TGFβ signaling in metastatic breast cancer cells. Methods: Using Ingenuity Pathway Analysis we analyzed a gene expression array comparing the triple-negative metastatic SUM159 breast cancer cells and their counterparts that were stably restored for Merlin expression. TGFβ was identified as a significant upstream regulator. TGFβ signaling was analyzed in these cells via a SBE4-luc luciferase assay. Signaling was further analyzed by Western blots for SMAD and phospho-SMAD proteins. Results and Conclusions: Re-expression of Merlin in metastatic breast cancer cells with low-levels of endogenous Merlin decreases TGFβ signaling, demonstrated by decreased luciferase assay activity, decreased rSMAD expression, decreased coSMAD expression and increased iSMAD protein levels. Future studies will explore the nature of this Merlin-dependent decrease in TGFβ signaling. Acknowledgments: R01CA138850 to L. A. Shevde Citation Format: William P. Jackson, Kelly M. Kreitzburg, Shamik Das, Sarah K. Bailey, Brandon J. Metge, Rajeev S. Samant, Lalita R. Shevde-Samant. The tumor suppressor Merlin decreases TGFβ/Smad signaling in metastatic breast cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2466. doi:10.1158/1538-7445.AM2014-2466
Human mast cell carboxypeptidase. Purification and characterization.
Authors: S M Goldstein, C E Kaempfer, J T Kealey, B U Wintroub
Journal: Journal of Clinical Investigation (1989)

A carboxypeptidase activity was recently identified in highly purified human lung mast cells and dispersed mast cells from skin. Using affinity chromatography with potato-tuber carboxypeptidase inhibitor as ligand, mast cell carboxypeptidase was purified to homogeneity from whole skin extracts. The purified enzyme yielded a single staining band of approximately 34,500 D on SDS-PAGE. Carboxypeptidase enzyme content estimated by determination of specific activity, was 0.5, 5, and 16 micrograms/10(6) mast cells from neonatal foreskin, adult facial skin, and adult foreskin, respectively. Human mast cell carboxypeptidase resembled bovine carboxypeptidase A with respect to hydrolysis of synthetic dipeptides and angiotensin I, but was distinguished from carboxypeptidase A in its inability to hydrolyze des-Arg9 bradykinin. The amino acid composition of human mast cell carboxypeptidase was similar to the composition of rat mast cell carboxypeptidase. The amino-terminal amino acid sequence of mast cell carboxypeptidase demonstrated 65% positional identity with human pancreatic carboxypeptidase B, but only 19% with human carboxypeptidase A. Thus, human mast cell carboxypeptidase is a novel member of the protein family of zinc-containing carboxypeptidases, in that it is functionally similar but not identical to bovine carboxypeptidase A, but has structural similarity to bovine and human pancreatic carboxypeptidase B.
Physician Compliance with Guidelines
Authors: A. Gray Ellrodt
Journal: Annals of Internal Medicine (1996)

Letters1 January 1996Physician Compliance with GuidelinesA. Gray Ellrodt, MDA. Gray Ellrodt, MDCedars-Sinai Medical Center; Los Angeles, CA 90048Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-1_Part_1-199601010-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Ms. Jung raises several important issues about physician compliance with clinical practice guidelines. We purposely used the term compliance because it is commonly applied to “conformance” with guideline recommendations. Our point was that before one assumes that physicians simply refuse to follow recommendations and are therefore “noncompliant,” a more in-depth review is required. I believe that Ms. Jung and we are in complete accord on this issue.Compliance rates for cardiologists, internists, and a combination of these two significantly differed. Compliance with the guideline was higher (84%) when internists alone cared for patients than when cardiologists alone (58%) ...REFERENCE1. Weingarten SM, Riedinger MS, Conner L, Lee TH, Hoffman I, Johnson B, et al. Practice guidelines and reminders to reduce duration of hospital stay for patients with chest pain. An interventional trial. Ann Intern Med. 1994; 120:257-63. Google Scholar Author, Article, and Disclosure InformationAffiliations: Cedars-Sinai Medical Center; Los Angeles, CA 90048 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1996Volume 124, Issue 1_Part_1Page: 78KeywordsCaregiversClinical trialsEvidence based medicineHealth care qualitySub-specialty careTreatment guidelines Issue Published: 1 January 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Carcinoma of the Breast
Authors: Rudolf J. Utzschneider, James C. McCann
Journal: New England Journal of Medicine (1960)

SINCE the introduction of radical mastectomy by Halsted and Willy Meyer toward the end of the nineteenth century, many surgeons throughout the country have used this particular procedure.The majority of reports attempting to evaluate this technic have been written by authors from large medical centers. It must be assumed that their selection of surgically eligible patients might differ somewhat from the material seen and treated in a community practice. Also, the reporting "cancer specialists" tend to have a larger experience with this particular technic.The purpose of this paper is to report and evaluate the experience of a community . . .
Obesity and the Risk of Heart Failure
Authors: Satish Kenchaiah, Jane C. Evans, Daniel Levy, Peter W.F. Wilson, Emelia J. Benjamin, Martin G. Larson, William B. Kannel, Ramachandran S. Vasan
Journal: New England Journal of Medicine (2002)

Extreme obesity is recognized to be a risk factor for heart failure. It is unclear whether overweight and lesser degrees of obesity also pose a risk.We investigated the relation between the body-mass index (the weight in kilograms divided by the square of the height in meters) and the incidence of heart failure among 5881 participants in the Framingham Heart Study (mean age, 55 years; 54 percent women). With the use of Cox proportional-hazards models, the body-mass index was evaluated both as a continuous variable and as a categorical variable (normal, 18.5 to 24.9; overweight, 25.0 to 29.9; and obese, 30.0 or more).During follow-up (mean, 14 years), heart failure developed in 496 subjects (258 women and 238 men). After adjustment for established risk factors, there was an increase in the risk of heart failure of 5 percent for men and 7 percent for women for each increment of 1 in body-mass index. As compared with subjects with a normal body-mass index, obese subjects had a doubling of the risk of heart failure. For women, the hazard ratio was 2.12 (95 percent confidence interval, 1.51 to 2.97); for men, the hazard ratio was 1.90 (95 percent confidence interval, 1.30 to 2.79). A graded increase in the risk of heart failure was observed across categories of body-mass index. The hazard ratios per increase in category were 1.46 in women (95 percent confidence interval, 1.23 to 1.72) and 1.37 in men (95 percent confidence interval, 1.13 to 1.67).In our large, community-based sample, increased body-mass index was associated with an increased risk of heart failure. Given the high prevalence of obesity in the United States, strategies to promote optimal body weight may reduce the population burden of heart failure.
Gene therapy for hepatic micrometastasis of murine colin carcinoma
Authors: Yasushi Shiratori, Fumihiko Kanai, Yoko Hikiba, Hiroshi Moriyama, Hirofumi Hamada, Masayuki Matsumura, Torao Tanaka, Keng-Hsin Lan, Makoto Ohashi, Ken'ichi Okano, Makoto Naito, Masao Omata
Journal: Journal of Hepatology (1998)
Biofeedback and Behavioral Approaches to Disorders of the Gastrointestinal Tract
Authors: Paul R. Latimer
Journal: Psychotherapy and Psychosomatics (1981)

Research Articles| February 16 2010 Biofeedback and Behavioral Approaches to Disorders of the Gastrointestinal Tract Subject Area: Psychiatry and Psychology Paul R. Latimer Paul R. Latimer Philadelphia Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1981) 36 (3-4): 200–212. https://doi.org/10.1159/000287544 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Paul R. Latimer; Biofeedback and Behavioral Approaches to Disorders of the Gastrointestinal Tract. Psychother Psychosom 31 December 1981; 36 (3-4): 200–212. https://doi.org/10.1159/000287544 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1981Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study
Authors: Sabine Stauch, Gerald Kircheis, Guideo Adler, Karlheinz Beckh, Hans Ditschuneit, Roman Görtelmeyer, Rüdiger Hendricks, Albert Heuser, Christian Karoff, Peter Malfertheiner, Dirk Mayer, Wolfgang Rösch, Jakob Steffens
Journal: Journal of Hepatology (1998)
Ibuprofen prevents oxidant lung injury and in vitro lipid peroxidation by chelating iron.
Authors: T P Kennedy, N V Rao, W Noah, J R Michael, M H Jafri, G H Gurtner, J R Hoidal
Journal: Journal of Clinical Investigation (1990)

Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene. Lungs from rabbits exposed to 2,000 ppm-min phosgene were perfused with Krebs-Henseleit buffer at 50 ml/min for 60 min. Phosgene caused no increase in lung generation of cyclooxygenase metabolites and no elevation in pulmonary arterial pressure, but markedly increased transvascular fluid flux (delta W = 31 +/- 5 phosgene vs. 8 +/- 1 g unexposed, P less than 0.001), permeability to albumin (125I-HSA) lung leak index 0.274 +/- 0.035 phosgene vs. 0.019 +/- 0.001 unexposed, P less than 0.01; 125I-HSA lavage leak index 0.352 +/- 0.073 phosgene vs. 0.008 +/- 0.001 unexposed, P less than 0.01), and lung malondialdehyde (50 +/- 7 phosgene vs. 24 +/- 0.7 mumol/g dry lung unexposed, P less than 0.01). Ibuprofen protected lungs from phosgene (delta W = 10 +/- 2 g; lung leak index 0.095 +/- 0.013; lavage leak index 0.052 +/- 0.013; and malondialdehyde 16 +/- 3 mumol/g dry lung, P less than 0.01). Because iron-treated ibuprofen failed to protect, we studied the effect of ibuprofen in several iron-mediated reactions in vitro. Ibuprofen attenuated generation of .OH by a Fenton reaction and peroxidation of arachidonic acid by FeCl3 and ascorbate. Ibuprofen also formed iron chelates that lack the free coordination site required for iron to be reactive. Thus, ibuprofen may prevent iron-mediated generation of oxidants or iron-mediated lipid peroxidation after phosgene exposure. This suggests a new mechanism for ibuprofen's action.
Evanescent Parotitis in Diabetes Mellitus
Authors: R. D. Lawrence
Journal: BMJ (1966)

not deduce cause and effect from this.My own work showed that the popliteal artery below the level of the knee-joint rarely develops atherosclerotic plaques, and large collaterals seldom arose from this segment.Robertson's work' showed that intimal cushions develop at the origin of branches in the femoral and popliteal arteries and these are transformed into atherosclerotic plaques with increasing age.If this work is valid, plaques are likely to develop in regions where branches are numerous-that is, in the adductor region and in the popliteal artery a few centimetres above the knee-joint-and plaques are less likely to develop where branches are uncommon-that is, in the popliteal artery below the level of the knee- joint.The less severe atherosclerotic changes found in the distal part of the popliteal artery seem therefore to be due to the protective effect of occlusions occurring proximally and to the absence of large branches in this segment of the popliteal artery.-Iam, etc.,
Physiology of the Digestive Tract; an Introductory Text
Authors: Joel Shilling
Journal: JAMA (1961)

This text is concisely written. The style and language are clear and to the point. Many of the examples in the book have a humorous twist, and on the whole, the presentation is excellent. The many illustrations and graphs are clear and supplement the text material extensively. The roentgenograms help the reader to easily observe the point implied, and the explanatory legends accompanying the illustrations serve as an additional aid. Throughout, the author outlines the subject in detail and ends each article with a concise summary sentence. The text is centered around 3 main divisions, or as the author prefers to call them, "Three trips through the digestive tract." The first trip concerns motility of the tract contents, the second the secretions encountered along the way, and the third the digestion and absorption functions of the system. Mechanics, pressures, and pressure gradients are discussed in detail; digestive gland secretions and
SI UNITS IS NUTSI
Authors: Stanley N. Schwartz
Journal: JAMA (1987)

"What?" I asked. "SMA-What?" "Seven," said the resident. "It's an SMA-7 now. We don't even have an 'SMA-6' anymore." She went on to explain: "The SMA-7 includes a creatinine, which you always need anyway." Not every single time, I thought, embarrassed to show my professional age. This young resident would never really understand the BUN—the more artistic, the more variable, the more expressive BUN. The creatinine was, well, unexciting. Mundane. Ordinary. Sotto voce. Doesn't vary so much with renal perfusion. Not affected by GI bleeding. It's so reliable. A walker, not a dancer. Well, I can live with this change. It'll probably help in the end by functioning as a fail-safe against the gullible and naive who can be hoodwinked by the capricious BUN. But now there's this crazy move afoot to change the language of medicine. I'm not sure I can be so complacent about this change. Those scientists—the