Acute Renal Failure Associated with Rofecoxib
Authors: Gunter Wolf
Journal: Annals of Internal Medicine (2000)

Letters5 September 2000Acute Renal Failure Associated with RofecoxibGunter Wolf, MD, Julia Porth, MD, and Rolf A.K. Stahl, MDGunter Wolf, MDUniversity Hospital Eppendorf; D-20246 Hamburg, Germany (Wolf, Porth, Stahl)Search for more papers by this author, Julia Porth, MDUniversity Hospital Eppendorf; D-20246 Hamburg, Germany (Wolf, Porth, Stahl)Search for more papers by this author, and Rolf A.K. Stahl, MDUniversity Hospital Eppendorf; D-20246 Hamburg, Germany (Wolf, Porth, Stahl)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-5-200009050-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Cyclooxygenase (COX) consists of two isoforms and is the key enzyme in the biosynthesis of the prostaglandins (1). The so-called “unspecific” nonsteroidal anti-inflammatory drugs nonselectively inhibit both COX isoenzymes, and the adverse effects of these agents on renal function are well known (1). The newly developed “selective” COX-2 inhibitors are assumed to exhibit fewer, if any, side effects because the activity of COX-1, which is responsible for the physiologic functions of prostaglandins, is not antagonized.A 49-year-old patient who had undergone renal transplantation was admitted because of suspected acute rejection. Transplantation of a cadaver kidney had been ...References1. Schneider A, Stahl RA. Cyclooxygenase-2 (COX-2) and the kidney: current status and potential perspectives. Nephrol Dial Transplant. 1998;13:10-2. CrossrefMedlineGoogle Scholar2. Daniels B, Gertz B, Morrison B, Seidenberg B. Renal safety profile of rofecoxib, a specific inhibitor of COX-2, in controlled clinical trials [Abstract]. Arthritis Rheum. 1999;42 Suppl 9 S143. Google Scholar3. Stahl RA. Non-steroidal anti-inflammatory agents in patients with a renal transplant. Nephrol Dial Transplant. 1998;13:1119-21. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Gunter Wolf, MD; Julia Porth, MD; Rolf A.K. Stahl, MDAffiliations: University Hospital Eppendorf; D-20246 Hamburg, Germany (Wolf, Porth, Stahl) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byToxic NephropathiesRisikostratifizierung in der Rheumatologie: Analgetika-TherapieCOX-2 inhibitors (coxibs)Nonsteroidal Anti-Inflammatory Drugs and the KidneyRofecoxib: an update on physicochemical, pharmaceutical, pharmacodynamic and pharmacokinetic aspectsNON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)Special Issue: KDIGO Clinical Practice Guideline for the Care of Kidney Transplant RecipientsRenal adverse effects of nonsteroidal anti-inflammatory drugsNon-steroidal anti-inflammatory drugsCOX-2 inhibitorsCelecoxib-Induced Nephrotoxicity in a Renal Transplant RecipientComplications rénales des anti-inflammatoires non stéroïdiensSevere Cholestasis and Acute Renal Failure Related to RofecoxibCOX-2 inhibition and prostaglandin receptors in experimental nephritisAdverse Drug Events Involving COX-2 InhibitorsNon-steroidal anti-inflammatory drugsNovel therapies for the treatment of juvenile rheumatoid arthritis (juvenile idiopathic arthritis)Pharmacokinetics of RofecoxibThe Renal Effects of Traditional Nonsteroidal Anti-Inflammatory Agents Versus Cyclooxygenase-2 InhibitorsCyclooxygenase-2 Inhibitor–Associated Acute Renal Failure: Case Report with Rofecoxib and Review of the LiteratureBeneficios y riesgos de los antiinflamatorios no esteroides inhibidores selectivos de la ciclooxigenasa-2Anti-inflammatory and antipyretic analgesics and drugs used in goutRenal Failure Associated with the Use of Celecoxib and RofecoxibRenal and cardiovascular effects of selective cyclooxygenase-2 inhibitorsAcute Renal Failure Can Occur with Inappropriate Use of a CoxibNephrotoxicity in the Elderly Due to Co-Prescription of ACE Inhibitors and NSAIDsNew drug therapies for the pediatric rheumatic diseasesRenal effects of cyclooxygenase-2 selective inhibitorsRenal aspects of treatment with conventional nonsteroidal anti-inflammatory drugs versus cyclooxygenase-2–specific inhibitorsPharmacoepidemiology and drug safetyThe ever-emerging anti-inflammatories. Have there been any real advances?Intelligent use of NSAIDs - where do we stand?RofecoxibCOX-2 Inhibition: A Cautionary Note in Congestive Heart Failure 5 September 2000Volume 133, Issue 5Page: 394KeywordsAcute renal failureAttentionCreatinineCyclooxygenase 2DrugsKidneysProstaglandinsRenal transplantationToxicityTransplantation ePublished: 5 September 2000 Issue Published: 5 September 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...