Non-Antibiotic-Associated Pseudomembranous Colitis Due to Toxin-Producing Clostridia
Authors: Arnold Wald, Harvey Mendelow, John G. Bartlett
Journal: Annals of Internal Medicine (1980)

Brief Reports1 June 1980Non-Antibiotic-Associated Pseudomembranous Colitis Due to Toxin-Producing ClostridiaARNOLD WALD, M.D., HARVEY MENDELOW, M.D., JOHN G. BARTLETT, M.D.ARNOLD WALD, M.D.Search for more papers by this author, HARVEY MENDELOW, M.D.Search for more papers by this author, JOHN G. BARTLETT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-6-798 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years pseudomembranous colitis has most often been described in a setting of antibiotic therapy. Recent studies have implicated toxin-producing clostridia organisms in the intestine in the pathogenesis of antibiotic-associated pseudomembranous colitis (1-3). Clinical disease has been reported to occur as late as three weeks after discontinuing antibiotic therapy (4). To our knowledge, all but one of the reported cases of pseudomembranous colitis in which the clostridia toxin has been found in fecal extracts have occurred in the setting of antibiotic therapy. This report describes a previously healthy woman who was found to have pseudomembranous colitis without known exposure...References1. BARTLETTCHANGGURWITHGORBACHONDERDONK JTMSA. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med. 1978;298:531-4. CrossrefMedlineGoogle Scholar2. RIFKINSILVAFEKETY GJR. Gastrointestinal and systemic toxicity of fecal extracts from hamsters with clindamycin-induced colitis. Gastroenterology. 1978;74:52-7. CrossrefMedlineGoogle Scholar3. LARSONPRICE HA. Pseudomembranous colitis: presence of clostridial toxin. Lancet. 1977;2:1312-4. CrossrefMedlineGoogle Scholar4. TEDESCOBARTONALPERS FRD. Clindamycin-associated colitis: a prospective study. Ann Intern Med. 1974;81:429-33. LinkGoogle Scholar5. PRICEDAVIES AD. Pseudomembranous colitis. J Clin Pathol. 1977;30:1-12. CrossrefMedlineGoogle Scholar6. ASWELLEHRICHVANTASSELLTSAIHOLDEMANWILKINS JMRCLT. Characterization and comparison of Clostridium difficile and other clostridial toxins. In: SCHLESSINGER D, ed. Microbiology—1979. Washington, D.C.: American Society for Microbiology; 1979:272-5. Google Scholar7. GOULSTONMCGOVERN SV. Pseudo-membranous colitis. Gut. 1965;6:207-12. CrossrefMedlineGoogle Scholar8. TEDESCOGURWITHMARKHAMCHRISTIEBARTLETT FMRDJ. Oral vancomycin for antibiotic-associated pseudomembranous colitis. Lancet. 1978;2.226-8. CrossrefMedlineGoogle Scholar9. KEIGHLEYBURDONARABI MDY. Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea. Br Med J 1978;2:1667-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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GAEKE, M.D., DAVID CAVE, M.D., PH.D., JOSEPH B. KIRSNER, M.D., PH.D. 1 June 1980Volume 92, Issue 6Page: 798-799KeywordsAntibioticsC difficile colitisPathogenesisToxins Issue Published: 1 June 1980 PDF DownloadLoading ...