tbuckley/cabot-search huggingface dataset:
MULTIPLE SUBCUTANEOUS TUBERCULOSIS FOLLOWING CIRCUMCISION AND TREATED BY TUBERCULIN
Authors: S. T. Champtaloup
Journal: BMJ (1914)

lhave previously suppurated, give real diffictulty wlhen in close contact witlh inerves or large vessels.We use blunt:pointed scissors curved on tlle flat, a stronig tissue separator, and special ring-slhaped gland forceps witlh a spritng catcli and long handles, whlich enable an assistailt to assist tlle operator.Drainage slhould be euployed in extensive alid doubtful cases.But we do not favour drainage ttubes for aseptic cases; a narrow gauze wick suffices.Tlhe laslimir sawv- dust pads are useful as outside dressings, and, with a well- applied knitted baud(lage of loose mieshi, the head is com- fortably fixed almost as if splinted.We remove the drain usually after twenty-four hiours, and tllen do not dress aseptic cases till the ninth day, wlhen tlle stitchles are remioved.For ligatures we use locally prepared iodine- clhronmic gut, and tor sutures local silk thlread.So far as I can judge, tlle end results are very satisfac- tory.I lhave not scen pulmlonary plltllisis as a later com- plication, nor tuberculous peritonitis.Tllere is an increase of pulmonary tubercle in Kashmir, but nio apparent increase in glanidular disease.The clim-iate is favourable, and it is proposed slhortly to start a State sanatoriumu, which is likely to attract tuberculous patients from the plains of Northi India.
UEGW Report 2008: Putting endoscopy into perspective
Authors: I. Papanikolaou, T. Rösch
Journal: Endoscopy (2009)

The 16th United European Gastroenterology Week (UEGW), which was held in Vienna in October 2008, provided the opportunity for those interested in gastrointestinal endoscopy to be informed of the experience of colleagues throughout the world and to become acquainted with the latest advancements and research in the field. Many of these abstracts focused on innovations and new techniques, and numerous others concentrated on topics with an impact on everyday clinical practice. This report attempts to highlight mostly oral presentations but also a few selected poster presentations, and each will be briefly reviewed in the light of recent publications in the respective fields of gastrointestinal endoscopy.
Going both ways: Immune regulation via CD1d-dependent NKT cells
Authors: Dale I. Godfrey, Mitchell Kronenberg
Journal: Journal of Clinical Investigation (2004)

NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation of immune responses associated with a broad range of diseases, including autoimmunity, infectious diseases, and cancer. In stark contrast to both conventional T lymphocytes and other types of Tregs, NKT cells are reactive to the nonclassical class I antigen–presenting molecule CD1d, and they recognize glycolipid antigens rather than peptides. Moreover, they can either up- or downregulate immune responses by promoting the secretion of Th1, Th2, or immune regulatory cytokines. This review will explore the diverse influences of these cells in various disease models, their ability to suppress or enhance immunity, and the potential for manipulating these cells as a novel form of immunotherapy.
Response to Sunitinib in an Adult Patient With Rhabdoid Renal Cell Carcinoma
Authors: Fabio De Vincenzo, Paolo Andrea Zucali, Giovanni Luca Ceresoli, Piergiuseppe Colombo, Matteo Simonelli, Elena Lorenzi, Matteo Perrino, Letizia Gianoncelli, Rita De Sanctis, Pierpaolo Graziotti, Armando Santoro
Journal: Journal of Clinical Oncology (2011)
Medicare Turns to HMOs
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1985)

After more than a decade of congressional debate and five years of program experimentation, the federal government is on the threshold of launching a major effort to enroll Medicare beneficiaries in health maintenance organizations (HMOs) and other competitive medical plans that are eligible to negotiate at-risk contracts with the Department of Health and Human Services. Last May, when the department proposed regulations to implement this new policy — approved with strong bipartisan congressional support — Secretary Margaret M. Heckler characterized the move as "another historic step in reforming our Medicare system."The movement to marry Medicare with HMOs and other . . .
Dr. Holmes at 200 — The Spirit of Skepticism
Authors: Charles S. Bryan, Scott H. Podolsky
Journal: New England Journal of Medicine (2009)

This week marks the bicentennial of the birth of Oliver Wendell Holmes (August 29, 1809–October 7, 1894), who at various times during the 19th century was America's best-known physician and best-selling author. His essay on the contagiousness of puerperal fever (1843), which prefigured the germ theory by two decades, constitutes his strongest claim to medical immortality. He also introduced microscopy to North American medical students, championed bedside teaching, coined the terms “anesthesia” and “anesthetic agents,” named tuberculosis “the white plague,” and critiqued his era's therapies, from bloodletting to homeopathy. His “Breakfast-Table” series for the Atlantic Monthly (a periodical that he . . .
Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism
Authors: R. K. P. CHOW, W. D. STEWART, V. C. HO
Journal: British Journal of Dermatology (1996)

A case of graft-vs.-host disease (GVHD) arising solely within an area affected by piebaldism is described. The patient, a 35-year-old woman with a single hypopigmented patch on the right leg present since birth, had received an allogeneic bone marrow transplant (BMT) from an HLA-identical sibling donor, for treatment of a myelodysplastic syndrome (MDS). Beginning on day +38 post-BMT, the patch developed changes which were histologically consistent with GVHD. Syngeneic mixed epidermal cell-lymphocyte reaction (MECLR) testing of tissue from the patch, and from adjacent normal skin, showed differences which suggest that piebaldism-affected skin is immunologically different from normal skin. These findings may offer new insight into the pathophysiology of this disorder.
Mother is awarded 13m compensation after mistakes at births of two children
Authors: C. Dyer
Journal: BMJ (2015)

Two siblings have won £13m (€18m; $19.2m) in compensation for mistakes made at their births in the same UK hospital 17 months apart that left them both needing lifelong care.

The NHS Litigation Authority has agreed a £7m package for Natasha Jackson, now aged 24, five years after agreeing compensation of £6m for her 22 year old brother, Patrick. Both have cerebral palsy.

After errors by staff …
Clinical Detection of the Potential Allergic Reactor to Penicillin by Immunologic Tests
Authors: Howard E. Voss
Journal: JAMA (1966)

Eighty patients with past histories of penicillin allergy who required penicillin therapy were evaluated with several objective immunologic tests for the possibility of an allergic reaction to penicillin. All 68 patients with negative immediate skin tests to the major and minor penicillin skin test reagents tolerated penicillin without immediate or accelerated allergic reactions. Patients with positive skin tests had a high incidence of allergic reaction. Titer and antibody class (IgG or IgM) of hemagglutinating penicillin antibodies was not useful in predicting immediate allergic reactions but IgG titers were useful in predicting accelerated allergic reactions.
The comparative cost-effectiveness of an equity-focused approach to child survival, health, and nutrition: a modelling approach
Authors: Carlos Carrera, Adeline Azrack, Genevieve Begkoyian, Jerome Pfaffmann, Eric Ribaira, Thomas O'Connell, Patricia Doughty, Kyaw Myint Aung, Lorena Prieto, Kumanan Rasanathan, Alyssa Sharkey, Mickey Chopra, Rudolf Knippenberg
Journal: The Lancet (2012)
Transforming Growth Factor β Signaling, Vascular Remodeling, and Hypertension
Authors: Phyllis August, Manikkam Suthanthiran
Journal: New England Journal of Medicine (2006)

Mice deficient in Emilin1, an extracellular growth factor expressed in blood vessels, have hypertension. This observation, together with the finding that Emilin1 regulates the availability of transforming growth factor β (TGF-β), contributes to a growing body of evidence implicating TGF-β in hypertension.
Primary Care as Part of US Health Services Reform
Authors: Jay Siwek
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Starfield and Simpson<sup>1</sup>outline some important steps for bolstering the role of primary care physicians in health care reform. But one problem they don't address is that of medical bigotry. By this I mean the prejudice that exists at many of our medical institutions against the specialty of family practice. I single out family practice from the other primary care specialties of general internal medicine and pediatrics because by and large they don't face this problem. But ask just about any medical student interested in family practice, and I think the odds are that they've been subjected to pervasive negative propaganda from attending physicians in other specialties. I interview medical students from all over the country, and the tales they tell are all too familiar to me and my colleagues in family medicine. Here's a sample of what they hear: "Why would you want to go
Interaction of benzodiazepines with tricyclic antidepressants.
Authors: G Silverman, R Braithwaite
Journal: BMJ (1972)

Coombs test negative.There was a gross deficiency of erythrocyte G-6-PD.The patitnt was transferred to another job.After a month the blood findings had returned practically to normal; the urine contained no urobilin; and the serum bilirubin was 0-5 mg/100 ml.We believe that the acute haemolytic crisis in this patient was due to nalidixic acid.The patient had not eaten broad beans nor taken any haemolysing drugs, nor had he come into contact with any other haemolysing substances in his work.We record this case to draw attention to the importance of G-6-PD-screening in subjects who are occupationally exposed to nalidixic acid or other haemolysing drugs.-Weare, etc.,
Folic Acid Supplementation and Cardiovascular Diseases
Authors: Francesco Dentali, Monica Gianni, Walter Ageno
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical outcome in differentiated thyroid carcinoma and microcarcinoma
Authors: Roberta Lupoli, Marianna Cacciapuoti, Anna Tortora, Livia Barba, Nunzia Verde, Fiammetta Romano, Maria Vastarella, Francesco Fonderico, Stefania Masone, Marco Milone, Giovanni Lupoli, Gelsy Arianna Lupoli
Journal: International Journal of Surgery (2014)
Measles Immunization
Authors: Anne S. Yeager
Journal: JAMA (1977)

As a result of a large community outbreak of measles, measles hemagglutination inhibition (HI) titers were measured in 465 immunized children. Titers of less than 1:4 were found in 14.6% of children immunized at 12 months of age as compared to 5.2% of those immunized at 13 months of age or later. Measles antibody titers were higher in the mothers of seronegative children who had been immunized at 11 or 12 months of age than in the mothers of seropositive children. Measles HI titers of 1:4 or more were present in 94% of children immunized at 13 months of age or later between 1962 and 1964. The findings suggest that vaccine failure and not waning antibody accounts for the majority of titers of less than 1:4 in immunized children. Reimmunization programs should be considered for those who were immunized before 13 months of age. (<i>JAMA</i>237:347-351, 1977)
Vitamin E, Memantine, and Alzheimer Disease
Authors: Denis A. Evans, Martha Clare Morris, Kumar Bharat Rajan
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trends in the Epidemiology of IDDM During 1970–2020 in Fyn County, Denmark
Authors: Anders Green, Anne K Sjølie, Ole Eshøj
Journal: Diabetes Care (1996)

To present an epidemiological model applicable to diabetes based on which prevalence rates are estimated from assumed rates of incidence and mortality of diabetes. Furthermore, this study illustrates the model by analyzing epidemiological data on IDDM in a Danish population during 1970-1990, with predictions of prevalence rates for 1990-2020.The epidemiological model assumes known prevalence rates as well as incidence rates and mortality at a given time. Under assumed rates of incidence and mortality of IDDM and its complications, the prevalence rate is the dependent variable, estimated as a function of calendar time. We use epidemiological data on IDDM (operationally defined as insulin-treated diabetes with onset before age 30 years), blindness, and nephropathy, as well as mortality, as reported for 1973 and 1987 in Fyn County, Denmark.During 1970-1990, the prevalence of IDDM increased steadily because of increasing incidence and decreasing risk of complications and mortality. The relative prevalence of patients with nephropathy increased, whereas that of blind patients decreased considerably. Under specified assumptions regarding the future levels of incidence of disease, complications, and mortality, it is estimated that the prevalence rate of IDDM in the year 2020 will be 45-60% higher than the level in the year 1990. The relative prevalence of patients with nephropathy will increase further, whereas the relative prevalence of blind patients will remain constant at a low level.IDDM will represent an increasing public health problem in Denmark during the next decades, with increasing overall prevalence rates and a rising proportion of patients with nephropathy. The major determinant of this trend is increasing incidence combined with declining mortality and declining risk of complications. It is strongly recommended that epidemiological models like the one presented here be further developed and implemented at regional levels to provide data for the dimensioning of the current and future diabetes care systems.
Serum transferrin as a liver fibrosis biomarker in patients with chronic hepatitis B
Authors: Hyo Jung Cho, Soon Sun Kim, Seun Joo Ahn, Joo Han Park, Dong Joon Kim, Young Bae Kim, Sung Won Cho, Jae Youn Cheong
Journal: Clinical and Molecular Hepatology (2014)

See the commentary-article "Angiotensin receptor blocker add-on therapy in portal hypertension: To use angiotensin receptor blocker or not to use, that is the question" on page 345.
A simplified method for quantitating left-to-right shunts from arterial dilution curves.
Authors: B E Victorica, I H Gessner
Journal: Circulation (1975)

This report presents a new, simple and reliable method of quantitating left-to-right shunts from arterial dilution surves. When indicatior (e,g., indocyanine green) is injected centrally (right venticle or pulmonary artery) and blood is withdrawn rapidly from either the aorta or other central systemic artery, in the presence of a left-to-right shunt to recorded indicator-dilution curve usually shows two discrete peaks: p-1 of the magnitude of the shunt expressed as percent of pulmonary blood flow, Experimental and clinical data demonstrate that this method is accurate in quantitating shunts from such curves.
Value of the SYNTAX Score for Risk Assessment in the All-Comers Population of the Randomized Multicenter LEADERS (Limus Eluted from A Durable versus ERodable Stent coating) Trial
Authors: Joanna J. Wykrzykowska, Scot Garg, Chrysafios Girasis, Ton de Vries, Marie-Angele Morel, Gerrit-Anne van Es, Pawel Buszman, Axel Linke, Thomas Ischinger, Volker Klauss, Roberto Corti, Franz Eberli, William Wijns, Marie-Claude Morice, Carlo di Mario, Robert Jan van Geuns, Peter Juni, Stephan Windecker, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2010)
Treatment of the Hiccups
Authors: Russel D. Bussdicker
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Klaus Hergt, MD, recorded an effective relief of hiccups by vomiting (<b>195</b>:877, 1966). Having been a resident of Iran for 36 years and acquired knowledge of Persian, I became the owner of one volume, entitled<i>The Therapeutics of Joseph.</i>This was written in Herat in the year 917 ah, corresponding to 1511 ad. The author is Joseph, son of Mohamad, son of Joseph the Doctor. The book treats of numerous diseases, arranged according to the systems of the body, and outlines treatment of these diseases in verse. Of hiccup, called<i>Hakchi</i>in old Persian and<i>Fovak</i>in Arabic, and recognized as resulting from eating heavy and rich food, the author says: My liberal translation of this runs: When flatulence brings hiccups, that which proves a friend Must be used; a vomitive we strongly recommend, And that which had been hiccups, by vomiting Is cured, and no
Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma
Authors: Claus Bachert, Nan Zhang, Gabriele Holtappels, Lizzy De Lobel, Paul van Cauwenberge, Shixi Liu, Ping Lin, Jean Bousquet, Kristel Van Steen
Journal: Journal of Allergy and Clinical Immunology (2010)
Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo
Authors: Jin-Ping Lai, Dalbir S. Sandhu, Catherine D. Moser, Sophie C. Cazanave, Abdul M. Oseini, Abdirashid M. Shire, Viji Shridhar, Schuyler O. Sanderson, Lewis R. Roberts
Journal: Journal of Hepatology (2009)
Findings of Subdural Hematoma on Tc-99m-TRODAT-1 SPECT
Authors: Te-Chun Hsieh, Chia-Hung Kao, Yu-Chin Wu, Chih-Hsiu Wang, Kuo-Yang Yen, Shung-Shung Sun
Journal: Clinical Nuclear Medicine (2009)

Chronic subdural hematoma (SDH) is difficult to diagnose by clinical manifestations only. Nonspecific neurologic symptoms and signs may lead physicians to make other diagnoses. Although head trauma is the most common cause, it may be considered insignificant or omitted due to its minor initial manifestations. We present a patient with an incidental finding of SDH on Tc-99m-TRODAT-1 SPECT that was originally done for evaluation of his Parkinsonism. This reminds us to be vigilant about other possible coincidental findings on routine examinations.
Gene therapy for lysosomal storage diseases
Authors: Mark S. Sands, Beverly L. Davidson
Journal: Molecular Therapy (2006)

Lysosomal storage diseases (LSDs) comprise a diverse group of monogenetic disorders with complex clinical phenotypes that include both systemic and central nervous system pathologies. In recent years, the identification or development of mouse models recapitulating the clinical course of the LSDs has been instrumental in evaluating therapeutic strategies. Here, we review the various gene replacement strategies for target organs affected in many LSDs and describe briefly the various vector systems employed to test how best to accomplish long-lasting therapies for these fatal disorders.
Fortnightly review: Diet and the prevention of cancer
Authors: J. H Cummings, S. A Bingham
Journal: BMJ (1998)

Cancer is responsible for more deaths annually in the United Kingdom than is ischaemic heart disease. Around half of cancer deaths are due to tumours at four principal sites: lung, bowel, breast, and prostate. These cancers are virtually absent in many countries in the developing world but increase in incidence within one or two generations when migrants move from low to high risk areas.1 Thus many cancers common in Western populations are due to environmental factors, and these cancers should be largely preventable.

Diet is one of the most important lifestyle factors and has been estimated to account for up to 80% of cancers of the large bowel, breast, and prostate. 2 3 Even lung cancer may have a dietary component, although cigarette smoking is the overwhelming cause of this and contributes also to oropharyngeal, oesophageal, and bladder cancer. Physical activity, reproductive and sexual behaviour, infection with hepatitis B and C viruses, infection with helicobacter, and exposure to sunlight, ionising radiation, and environmental chemicals are also important at particular sites. Nevertheless, food and drink has a part to play in many if not all cancers, albeit to a variable extent.

#### Summary points

This review has been prompted by the recent publication of two reports, one from the Chief Medical Officer's Committee on Medical Aspects of Food (COMA) and one commissioned by the World …
A single amino acid substitution in the human histocompatibility leukocyte antigen DR3 beta chain selectively alters antigen presentation.
Authors: E Mellins, B Arp, B Ochs, H Erlich, D Pious
Journal: The Journal of Experimental Medicine (1988)

Activation of T lymphocytes by immunogenic peptides bound to HLA molecules is a central event in the generation of an immune response. To determine the sites on HLA molecules involved in this process, we isolated mutant EBV-transformed B cell clones that express altered HLA-DR3 molecules. One mutant has lost the ability to stimulate a T cell clone specific for a mycobacterial protein, but retains the ability to stimulate other antigen-specific T cells. The DNA sequence of the complete DR alpha and beta coding regions revealed a single nucleotide change resulting in a glutamic acid to lysine substitution at amino acid 9 in the first hypervariable region of the DR beta chain. These results are discussed in relation to a recently proposed model of class II molecule structure.
A Case of Scarlet Fever in a Canary
Authors: F. Ogston
Journal: BMJ (1884)

form of obstruction, but to general uterine congestion, it will follow, as a matter of course, that tunnelling or other forcible dilatation is an unnecessarily radical and severe method of cure.We may hope that a course of counterirritation over the sacrum, by blisters or tincture of iodine, will reduce the congestion and prevent the recurrence of the pain.Other methods of relieving or preventing the pain will also suggest themselves, such as glycerine or alcohol-plugs, leeches, scarifi-