The Nephrotoxicity of Analgesic Abuse
Authors: GEORGE E. SCHREINER
Journal: Annals of Internal Medicine (1962)

Editorials1 December 1962The Nephrotoxicity of Analgesic AbuseGEORGE E. SCHREINER, M.D.GEORGE E. SCHREINER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-6-1047 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAbuse of analgesic tablets and powders has received increasing attention as a possible cause of uremia and papillary necrosis. Spühler and Zollinger (1), during a systematic investigation of interstitial nephritis, noted a considerable rise in the incidence of this lesion after 1950. They also observed a high frequency of medullary necrosis in their patients with interstitial nephritis that was rarely accompanied by either diabetes or urinary tract obstruction. Aware of an increase in phenacetin consumption in their country, they elicited a history of phenacetin abuse in some of their patients and correlated all these facts to suggest an association between...References1. SPÜHLERZOLLINGER OHU: Die chronisch interstitielle Nephritis. Z. Klin. Med. 151: 1, 1953. MedlineGoogle Scholar2. ZOLLINGER HU: Chronische interstitielle Nephritis bei Abusus von phenacetinhaltigen Analgetica (Saridon usw.). Schweiz. Med. Wschr. 85: 746, 1955. MedlineGoogle Scholar3. MOESCHLIN S: Acetophenetidin (phenacetin) as cause of addiction and disorders; anemia with Heinz's bodies and interstitial nephritis. Schweiz. Med. Wschr. 87: 123, 1957. MedlineGoogle Scholar4. LARSENMØLLER KCE: A renal lesion caused by abuse of phenacetin. Acta Med. Scand. 164: 53, 1959. CrossrefMedlineGoogle Scholar5. LINDENEGFISCHERPEDERSENNISSEN OSJNI: Necrosis of the renal papillae and prolonged abuse of phenacetin. Acta Med. Scand. 165: 321, 1959. CrossrefMedlineGoogle Scholar6. NORDENFELTRINGERTZ ON: Phenacetin takers dead with renal failure. Acta Med. Scand. 170: 385, 1961. CrossrefMedlineGoogle Scholar7. MIESCHERSCHNYDERKRECH PUU: Zur Pathogenese der "interstitiellen Nephritis" bei Abusus von phenacetinhaltigen Analgetica. Schweiz. Med. Wschr. 88: 432, 1958. MedlineGoogle Scholar8. EISALOTALANTI AS: Observations on the effect of phenacetin and n-acetyl-p-aminophenol on rat kidneys. Acta Med. Scand. 169: 655, 1961. CrossrefMedlineGoogle Scholar9. HARVALDVALDORF-HANSENNIELSEN BFA: Effect on the kidney of drugs containing phenacetin. Lancet 1: 303, 1960. CrossrefMedlineGoogle Scholar10. CLAUSENHARVALD EDB: Nephrotoxicity of different analgesics. Acta Med. Scand. 170: 469, 1961. CrossrefMedlineGoogle Scholar11. LORENZENSCHWARTZ IM: Phenacetin-induced haemolysis in patients with chronic nephritis and phenacetin abuse. Acta Med. Scand. 168: 461, 1960. CrossrefMedlineGoogle Scholar12. SCHAUBBÜHLMANNMAIER FAC: Nebenerscheinungen und Folgen des chronischen Phenacetin-abusus. Schweiz. Med. Wschr. 83: 626, 1953. MedlineGoogle Scholar13. SCHEIDEGGER S: Contribution to the problem of chronic phenacetin poisoning. Arch. Toxikol. 19: 19, 1961. CrossrefMedlineGoogle Scholar14. DORETJUNOD JJ: Néphrite interstitielle chronique et abus de phénacétine. J. Urol. Nephrol. (Par.) 65: 279, 1959. Google Scholar15. JASINKIWUHRMANN BF: Zur Frage der Schäden infolge Phenacetin-abusus. Schweiz. Med. Wschr. 88: 1290, 1958. MedlineGoogle Scholar16. NISSENPEDERSEN NIJ: Pyelonefritis og phenacetin. Ugeskr. Laeg. 119: 1639, 1957. MedlineGoogle Scholar17. PLETSCHER A: Ueber des Toxikologie des Phenacetins. Bull. Schweiz. Akad. Med. Wiss. 14: 100, 1958. MedlineGoogle Scholar18. ROSSIMÜHLETHALER GJ: Phenacetinabusus und chronisch interstitielle Nephritis. Helv. Med. Acta 25: 510, 1958. MedlineGoogle Scholar19. SARRE H: Zur Frage der toxischen Nierenschädigung bei chronischem Phenacetinabusus in Deutschland. Bull. Schweiz. Akad. Med. Wiss. 14: 131, 1958. MedlineGoogle Scholar20. SARREMOENCHKLUTHE HAR: Phenacetinabusus und Nierenschadigung, Georg Thieme Verlag, Stuttgart, 1958. Google Scholar21. SCHEIDEGGER S: Pathologisch-anatomischer Beitrag zur Frage der chronischen interstitiellen Nephritis im Anschluss an Abusus von phenacetin-haltigen Analgetica. Bull. Schweiz. Akad. Med. Weiss. 14: 139, 1958. MedlineGoogle Scholar22. SCHWEINGRUBER R: Probleme der chronischen Vergiftung mit kombinierten phenacetinpraeparaten. Schweiz. Med. Wschr. 85: 1162, 1955. MedlineGoogle Scholar23. STUDERZBINDEN AG: Experimenteller Beitrag zur Frage von Nierenschäden bei Abusus von phenacetinhaltigen Schmerzmitteln. Experientia 11: 450, 1955. CrossrefMedlineGoogle Scholar24. ZOLLINGER HU: Relationship of renal toxicity of drugs to pyelonephritis, in Biology of Pyelonephritis, 1st Ed., Little, Brown and Company, Boston, 1960, p. 59. Google Scholar25. MOOLTENSMITH SEIB: Fatal nephritis in chronic phenacetin poisoning. Amer. J. Med. 28: 127, 1960. CrossrefMedlineGoogle Scholar26. LAKEY WH: Interstitial nephritis due to chronic phenacetin poisoning. Canad. Med. Ass. J. 85: 477, 1961. MedlineGoogle Scholar27. SCHREINERMAHER GEJF: Functional and histologic study of phenacetin nephritis. (Abstract) Clin. Res. 10: April, 1962. Google Scholar28. YUGUTMAN TFAB: Paradoxical retention of uric acid by uricosuric drugs in low dosage. Proc. Soc. Exp. Biol. Med. 90: 542, 1955. CrossrefMedlineGoogle Scholar29. HARVALDVALDORF-HANSENNIELSEN BFA: Effect on the kidney of drugs containing phenacetin. Lancet 1: 303, 1960. CrossrefMedlineGoogle Scholar30. MANDEL EE: Renal medullary necrosis. Arch. Intern. Med. 91: 417, 1953. CrossrefGoogle Scholar31. SIMON HB: Renal papillary necrosis: a clinical pathological study of 42 cases. Thesis, University of Minnestota, March, 1952. Google Scholar32. LAULERSCHREINERDAVID DPGEA: Renal medullary necrosis. Amer. J. Med. 29: 132, 1960. CrossrefMedlineGoogle Scholar33. GSELLKIELHOLZHEGG OPJJ: Abuse of acetophenetidine: comparison of patients abusing acetophenetidine containing analgesics who were treated by psychiatrists and internists. Schweiz. Med. Wschr. 91: 1529, 1961; abstracted in JAMA 179: 217, 1962. MedlineGoogle Scholar34. MOESCHLIN S: Klinik und Therapie der Vergiftungen, 3d Ed., Georg Thieme Verlag, Stuttgart, 1959. Google Scholar35. STUDERZBINDENFUST AGB: Weitere tierexperimentelle Untersuchungen zur Frage Schmerzmittelmissbrauch und interstitielle Nephritis. Schweiz. Med. Wschr. 88: 469, 1958. MedlineGoogle Scholar36. BEESONROCHAGUZE PBHLB: Experimental pyelonephritis: influence of localized injury in different parts of the kidney on susceptibility to hematogenous infection. Trans. Ass. Amer. Physicians 70: 120, 1957. MedlineGoogle Scholar37. GOODMANGILMAN LSA: The Pharmacological Basis of Therapeutics, 2d Ed., The Macmillan Company, New York, 1956. Google Scholar38. HARROPWATERFIELD GARL: Sulfhemoglobinemia. JAMA 95: 647, 1930. CrossrefGoogle Scholar39. ESPERSEN T: Chronic phenacetin intoxication. Ugeskr. Laeg. 99: 993, 1937; abstracted in JAMA 109: 2026, 1937. Google Scholar40. JASINKIMÜLLER BD: Zur Pathogenese der toxisch-hämolytischen Anämien nach chronischem Phenacetinabusus. Schweiz. Med. Wschr. 80: 681, 1950. MedlineGoogle Scholar41. GSELL H: Phenacetinabusus und Nierenschädigung. Symposium, Freiburg I. Br. Georg Thieme Verlag, Stuttgart, 1958, p. 87. Google Scholar42. HOUSTONBARLOW IBAM: Acute hemolytic anemia and methemoglobinuria produced by phenacetin. Lancet 2: 1062, 1959. CrossrefGoogle Scholar43. SCHREINERMAHER GEJF: Uremia: The Biochemistry, Pathogenesis and Treatment, Charles C Thomas, Springfield, Illinois, 1961. Google Scholar44. MUIRHEADHALDENGROVES EEERM: Drug dependent Coombs (antiglobulin) test anemia; observations on aminine and acetophenetidin (phenacetin). Arch. Intern. Med. 101: 87, 1958. CrossrefGoogle Scholar45. MACGIBBONLOUGHRIDGEHOURIHANEBOYD BHLWDODW: Autoimmune hemolytic anemia with acute renal failure due to phenacetin and p-aminosalicylic acid. Lancet 1: 7, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE E. SCHREINER, M.D.Affiliations: Georgetown University Hospital 3800 Reservoir Road, N.W. Washington 7, D. C. 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PLASS, M.D.Quantitative Concepts in the Clinical Study of DrugsAnalgesic Drugs and Kidney DiseaseToxic effects ascribed to prolonged abuse of acetophenetidin (Phenacetin) 1 December 1962Volume 57, Issue 6Page: 1047-1052KeywordsAnalgesicsLesionsNecrosisNephritisRenal diseases ePublished: 1 December 2008 Issue Published: 1 December 1962 PDF downloadLoading ...