tbuckley/cabot-search huggingface dataset:
Repeated concanavalin a challenge in mice induces an interleukin 10-producing phenotype and liver fibrosis
Authors: Hubert Louis, Alain Le Moine, Eric Quertinmont, Marie-Odile Peny, Albert Geerts, Michel Goldman, Olivier Le Moine, Jacques Devière
Journal: Hepatology (2000)

Weekly injections of Concanavalin A (Con A) were performed in BALB/c mice to evaluate the pattern of cytokine production and liver injury. High serum levels of tumor necrosis factor α (TNF-α), interleukin 2 (IL-2), IL-4, and interferon gamma (IFN-γ) were found in the serum after the first 2 injections of Con A but rapidly decreased from the third injection. Conversely, IL-10 serum levels after repeated Con A challenge increased by 7 times from week 1 to 20. In vivo depletion studies indicated that CD4 + T cells are essential in IL-10 production. Hepatocyte necrosis was only observed after the first injections of Con A whereas centrilobular inflammatory infiltrates persisted up to 20 weeks. Perisinusoidal liver fibrosis was also increasingly detected in BALB/c mice, whereas no fibrous change was observed in nude mice after 6 weeks of Con A challenge. The number of stellate cells, detected by immunostaining, increased after 20 weeks of Con A injections. Liver cytokine messenger RNA (mRNA) expression after 20 weeks showed expression of transforming growth factor β1 (TGF-β1), IL-10, and IL-4 whereas IL-2 was no more expressed. The present study shows that mice repeatedly injected with Con A develop liver fibrosis. The cytokine-release pattern observed after 1 injection of Con A is rapidly shifted towards an immunomodulatory phenotype characterized by the systemic production of large amounts of IL-10.
Injuries sustained on "bouncy castles".
Authors: G. Singer, L. S. Freedman
Journal: BMJ (1992)

Injuries sustained on "bouncy castles" SIR,-We wish to report the dangers of playing on "bouncy castles."A bouncy castle is an inflatable children's playground, consisting essentially of a rubber matress inflated with air.Three walls generally surround the castle, with the fourth side open to allow entry and exit, but some castles are open on all four sides.They are popular in fairgrounds and recreational halls.During last summer five children and one adult were treated at Northwick Park Hospital for injuries sustained while they were playing on bouncy castles.All injuries were to the arm or neck.Three supracondylar fractures of the humerus occurred.Two of these required open reduction and internal fixation with Kirschner wires.The third was managed with a collar and cuff support.A girl aged 6 sustained a fracture of the mid-shaft of the humerus, which was managed with a hanging cast support.The neck injuries occurred in a 52 year old man and a 12 year old boy.These were both soft tissue injuries caused by flexion and were managed conservatively.
Role of arginine vasopressin and terlipressin as first-line vasopressor agents in fulminant ovine septic shock
Authors: Sebastian Rehberg, Christian Ertmer, Gabriele Köhler, Hans-Ulrich Spiegel, Andrea Morelli, Matthias Lange, Katharina Moll, Katrin Schlack, Hugo Van Aken, Fuhong Su, Jean-Louis Vincent, Martin Westphal
Journal: Intensive Care Medicine (2009)
Abstract 3525: Functional analysis of epidermal growth factor receptor tyrosine kinase inhibitors: A comparison of Afatanib, Lapatinib, and Gefitinib in human tumor primary cultures.
Authors: Robert Alan Nagourney, Paula J. Bernard, Eric Federico, Sophie Nguyen, Steven S. Evans
Journal: Cancer Research (2013)

Abstract Introduction: Targeting epidermal growth factor receptor (EGFr) tyrosine kinases has provided effective therapies for NSCLC, breast &amp; GI cancers. However, secondary mutations can confer resistance. New multi-targeted and/or irreversible inhibitors (TKI's) may overcome these mechanisms. We used the ex vivo analysis of programmed death (EVA/PCD) to compare the activity of the irreversible EGFr TKI, BIBW 2992 (Afatanib) with Gefitinib and Lapatinib and examined downstream signals with inhibitors of MEK/ERK &amp; PI3K/mTOR. Methods: Human tumor 1° culture microspheroids isolated from 54 individual-patient specimens obtained at surgery or aspiration were examined for EGFr-TKI induced programmed cell death, using morphologic &amp; metabolic endpoints as previously described (Nagourney R, Curr. Treat Opt in Oncol., 2006). Lethal concentration 50% (LC50’s) interpolated from 5-point dose response curves were compared and drug correlations were conducted by Pearson-Moment. Results: BIBW activity favored upper GI, NSCLC and ovary over breast and colorectal cancer. In NSCLC, EGFr mutation (+) tumors were significantly more sensitive than wild type to BIBW (P &amp;lt; .05). Patients relapsing after Erlotinib who carried T790M mutations remained BIBW sensitive despite Gefitinib resistance. BIBW activity correlated with Gefitinib (r = 0.35, P= 0.05) and the MEK/ERK inhibitor AZD 6244 (r = 0.43, P &amp;lt; 0.05) and trended to correlation with Lapatinib, but did correlate with mTOR or mTOR/PI3K inhibitors, Everolimus &amp; BEZ235. Of 3 patients treated with Afatanib, 2 of 3 showed benefit, 1 durable SD &amp; 1 durable PR. Conclusions: BIBW reveals activity in several tumor types including NSCLC, GI and ovary. In NSCLC LC50’s significantly favor EGFr mutation (+) ‘s with favorable results in T790M(+) patients. Correlations with AZD 6244 but not Everolimus or BEZ235, suggest MEK/ERK pathway to be the operative survival signal. EVA/PCD analysis in human tumor 1°cultures offers a platform to study novel strategies for EGFr-targeted therapies. Supported by the Vanguard Cancer Foundation &amp; the Nagourney Institute. Citation Format: Robert Alan Nagourney, Paula J. Bernard, Eric Federico, Sophie Nguyen, Steven S. Evans. Functional analysis of epidermal growth factor receptor tyrosine kinase inhibitors: A comparison of Afatanib, Lapatinib, and Gefitinib in human tumor primary cultures. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3525. doi:10.1158/1538-7445.AM2013-3525
Incorporation of Sulfate-S <sup>35</sup> and Glucosamine-1-C <sup>14</sup> into Heparin During Perfusion of Isolated Rat Liver
Authors: NICOLA Di FERRANTE, ANN L. MEYERS, LEON L. MILLER
Journal: Circulation Research (1964)

Sulfate-S 35 and glucosamine-1-C 14 are incorporated into heparin which has been added to the blood perfusing an isolated, surviving rat liver. Although both labels are firmly bound to heparin, such uptake does not necessarily indicate synthesis of the polymer. Despite the fact that the perfused heparin has undergone some moderate depolymerization, its biological activity remains unchanged. The presence in the bile of material containing hexuronic acid and hexosamine but deprived of anticoagulant activity suggests that products derived from heparin breakdown may be eliminated in the bile.
Clinical Trial of Calcium Ortho-Iodoxybenzoate
Authors: G. D. Kersley, N. R. W. Simpson
Journal: Annals of the Rheumatic Diseases (1950)

Calcium ortho-iodoxybenzoate and its precursors ortho-iodobenzoic acid and ortho-iodoso-benzoic acid were first described by Meyer and his co-workers in 1892.It contains two double-bonded oxygen atoms linked to the iodine.The use of this product in the treatment of arthritis has been reported on favourably by Young and Youmans (1926); Cottrell (1927); Millard Smith (1927, 1928); Young (1928); Harbinson (1929); and Cohen (1937).Pemberton (1939), however, reported its effect as being merely that of a glorified salicylate.The product has been available commercially as Arthrytin, Artox, Oxo-ate B, Calcoid, and Calsiod.Conditions of Test.-During the last year a small series of 22 cases of osteo-arthritis, threecases of ankylosing spondylitis, and two cases of rheumatoid arthritis have been the subject of a test of the drug at this hospital.It was made up in tablet form and administered orally.The tablets were supplied in two forms, marked A and B; one contained calcium ortho-iodoxybenzoate (Arthrytin), the other was a " dummy " tablet containing 2i gr.aspirin in an inert base.At no time until the conclusion of the test did anyone in the hospital know which tablets contained the drug under trial.The tablets were administered for at least 4 to 6 weeks.All patients were periodically assessed with regard to pain and limitation of movement; the latter was measured accurately by means of a goniometer.All patients were given routine physiotherapy and hydrotherapy during their stay in hospital, but no other treatment with the exception of the one under trial.Results.-Asregards limitation of movement, all patients showed some slight degree of improvement, but not more so than occurs with physiotherapy and hydro- therapy alone.It was therefore considered that this factor should not be taken into account in estimating the results.The diminishment of pain was of course purely subjective.Cases given Tablets A.-Nine cases of osteo-arthritis, two cases of rheumatoid arthritis, and three cases of ankylosing spondylitis were treated.All patients said that their pain was diminished to a lesser or greater degree, six of these patients told us that their pain was completely removed by such treatment.Most patients also said that they slept better.We found that the improvement started within 12 hours of beginning medication and stopped within 24 hours of ceasing to take the tablets.We had requests from both patients and their medical practitioners for the name of these tablets after they had returned home.174
Re: Marco Roscigno, Cesare Cozzarini, Roberto Bertini, et al. Prognostic Value of Lymph Node Dissection in Patients with Muscle-Invasive Transitional Cell Carcinoma of the Upper Urinary Tract. Eur Urol 2008;53:794–802
Authors: Shiu-Dong Chung, Hong-Jeng Yu, Shih-Chieh Chueh
Journal: European Urology (2008)
Rules for Auscultation
Authors: None Walshe
Journal: BMJ (1842)

RULES FOR AUSCULTATION.-FATJALDOSES OF QUININE.carefuilly investigated thc whole circuimstances of the case, find tllc charge of general neglect, and of neglect in this particular inistance, entirely disproved, and, tllerefore, they do not feel that they ought to request Mr. Sheward to resign.The guardians appeared to take the deepest interest in the business of the day, and to feel most earnestly with Mr. Temple that it was their duty to protect, if they could, their officers from such unexampled and wanton persecution as is disclosed in these two cases.-Worcester Herald, Dec. 17.
Polypill will not change prevention of heart disease
Authors: Susan Mayor
Journal: BMJ (2004)

Claims that the “polypill”—a combination of a statin, three antihypertensive drugs, folic acid, and aspirin—will cause a major change in the primary prevention of cardiovascular disease are flawed because they are extrapolated from evidence for the individual components, an epidemiologist claimed last week.

Shah Ebrahim, professor of epidemiology of ageing at the University of Bristol, argued that there was only theoretical evidence for the additive effects of the components of the polypill and that it was unlikely to translate into clinical practice.

Speaking at a debate at the recent European Society of Cardiology's annual meeting in Germany, …
A Prospective Study of Cigarette Smoking and Risk of Cataract Surgery in Women
Authors: Susan E. Hankinson
Journal: JAMA (1992)

<h3>Objective.</h3> —To examine prospectively the association between cigarette smoking and the risk of cataract extraction in women. <h3>Design.</h3> —Prospective cohort study beginning in 1980 with 8 years of follow-up. <h3>Setting.</h3> —United States, multistate. <h3>Participants.</h3> —Registered nurses 45 to 67 years of age and free of diagnosed cancer. There were 50 828 women included in 1980 and others were added as they became 45 years of age. <h3>Main Outcome Measure.</h3> —Incidence of senile cataract extraction. <h3>Results.</h3> —We documented 493 incident senile cataracts diagnosed and extracted during 470302 person-years of follow-up. The age-adjusted relative risk (RR) among women who smoked at least 65 pack-years was 1.63(95% confidence interval [Cl], 1.18 to 2.26; Pfor trend,.02). A similar increase in RR was noted when smoking was assessed in terms of number of cigarettes currently smoked or number of cigarettes smoked by past smokers. Results were also similar after adjusting for other potential risk factors for cataract. Smoking was also strongly associated with posterior subcapsular cataract specifically (RR, 2.59; 95% Cl, 1.49 to 4.50 for ≥65-pack-year smokers relative to nonsmokers). <h3>Conclusion.</h3> —Smoking appears to increase the risk of cataract extraction. (<i>JAMA</i>. 1992;268:994-998)
NEOINTIMAL CHANGES DURING AN EXTENDED PERIOD AFTER BARE-METAL STENT IMPLANTATION: INSIGHTS FROM INTERGRADED BACKSCATTER INTRAVASCULAR ULTRASOUND ANALYSIS
Authors: Shoichi Kuramitsu, Masashi Iwabuchi, Takenori Domei, Makoto Hyodo, Kyohei Yamaji, Yoshimitsu Soga, Shinichi Shirai, Kenji Ando, Koyu Sakai, Hiroyoshi Yokoi, Hideyuki Nosaka, Masakiyo Nobuyoshi
Journal: Journal of the American College of Cardiology (2011)
Fatal Anaphylactic Shock
Authors: Edgar F. Luton
Journal: JAMA (1961)

<h3>To the Editor:—</h3> InThe Journal(Oct. 29, 1960, p. 1200) the author writing concerning fatal anaphylactic shock following an intradermal skin test with horse serum tetanus antitoxin stated that a "skin test dose of 0.1 cc. horse serum tetanus antitoxin in 1:10 dilution with isotonic sodium chloride solution was given intradermally." Later he states that "the intradermal test should be given initially with a dilution no stronger than 1:100." It should be pointed out also that the proper skin test dose is approximately<i>0:01 cc.</i>when testing for the immediate type of allergy, which is the purpose of the horse serum test. Larger doses are not necessary and increase the hazard of the skin test. The volume necessary for this type of skin test is distinctly smaller than that commonly used for a delayed type of antibody, such as the one involved in the commonly used tuberculin-type skin test.
EVALUATION OF GUIDELINE-BASED APPROPRIATE ICD PLACEMENT AND THERAPY AMONG HYPERTROPHIC CARDIOMYOPATHY PATIENTS REFERRED FOR QUARTERNARY CARE
Authors: Kanika Mody, Vijayapraveena Paruchuri, Srihari Naidu, Joseph Germano, Todd Cohen, Kevin Marzo, Mario Garcia, Juan Gaztanaga
Journal: Journal of the American College of Cardiology (2012)
UNILATERAL DISEASE OF THE KIDNEY SIMULATING STONE.
Authors: JOSEPH RANSOHOFF
Journal: JAMA (1903)

When one considers the achievements in any field of surgery there is always one spot brighter than the rest by reason of especially good results; results obtained through faultless interpretation of symptoms and clinched by brilliant operation. In the field of renal surgery this applies to the operation for stone in the kidney, that is, when a stone is found. Unfortunately the elating thrill the surgeon expects to experience when the finger touches the stone in the opened kidney is not always felt; in its place is chagrin, if not discomfiture, when the fullest search fails to reveal the object sought for. To whom has it not occurred? A year ago the writer saw one of the foremost specialists in kidney surgery fail to find a stone in two cases within ten days. Were Tiffany to reivrite a paper presented before the American Surgical Association in 1889, he might readily
Transplantation of mesenchymal stem cells embedded in Atelocollagen® gel to the intervertebral disc: a potential therapeutic model for disc degeneration
Authors: Daisuke Sakai, Joji Mochida, Yukihiro Yamamoto, Takeshi Nomura, Masahiko Okuma, Kazuhiro Nishimura, Tomoko Nakai, Kiyoshi Ando, Tomomitsu Hotta
Journal: Biomaterials (2003)
Isotope bone scans: an assessment of their diagnostic use in polyarticular pain of uncertain origin
Authors: A Whallett
Journal: Annals of the Rheumatic Diseases (2003)

A 13 year old girl presented with auricular chondritis and recurrent episodes of unexplained chest pain, arthritis, bronchitis, conjunctivitis, prolonged steroid resistant alopecia areata, and a history of recurrent tonsillitis.Both the mosaic of autoimmunity and relapsing polychondritis were considered in the differential diagnosis.The patient was successfully treated with co-trimoxazole.The significance of co-trimoxazole, which is an antibiotic and an immunomodulatory drug, in the treatment of autoimmune disease is discussed.www.annrheumdis.
Health System Reform: New Challenges for Future Resident Physicians
Authors: Baruch S. Ticho
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathways to complement activation during cardiopulmonary bypass
Authors: D Royston
Journal: BMJ (1985)

extra cost of performing tests on an emergency basis.We consider that the incremental cost of such tests should be passed on to the requesting clinician.In this way there would be greater awareness of the additional costs entailed in performing such emergency tests.Clinicians would then be encouraged to judge whether a request could be delayed and incorporated into the routine work of the laboratory concerned.
The number and distribution of hepatic natural killer cells (pit cells) in normal rat liver: an immunohistochemical study*1
Authors: Dianzhong Luo, Karin Vanderkerken, Luc Bouwens, Peter J. K. Kuppen, Evelyne Crabbé, Eddie Wisse
Journal: Hepatology (1995)

Pit cells are a unique population of cells in sinusoids and peripheral blood, which can be considered natural killer (NK) cells with large granular lymphocyte (LGL) morphology. The aim of this study was to investigate the use of the monoclonal antibody (MAb) 3.2.3 as a specific marker of rat pit cells to detect their number and distribution in the liver. The number of 3.2.3-positive cells was comparable to the number of LGL in liver low-density (LD) and high-density (HD) pit cell fractions and in blood lymphocytes (P > .05). Immunoelectron microscopy showed that nearly all LGL in hepatic LD and HD and in blood fractions were 3.2.3 positive. Using MAb 3.2.3 immunoperoxidase staining, the mean number of pit cells in liver frozen sections was determined to be 13.7 +/- 1.1/mm2. The number of pit cells was similar in the different liver lobes (P > .05). Reduced nicotinamide-adenine dinucleotide (NADH) oxidase histochemical staining, to visualize a portal to central vein gradient, combined with immunostaining was used to analyze the lobular distribution of pit cells. We found that 61.3% (17.1/mm2) of pit cells were in the periportal area and 38.7% (10.8/mm2) in the central area. We conclude that MAb 3.2.3 can be used as a specific marker of rat pit cells and therefore can be used to quantify rat pit cell number in various experimental models.
Diffuse Intense FDG Uptake in the Bone Marrow in Gastrointestinal Stromal Tumor With Coexistent Polycythemia Rubra Vera
Authors: Sandip Basu, Ramesh Asopa, Harish Peshwe, K M. Mohandas
Journal: Clinical Nuclear Medicine (2008)

We report diffuse intense FDG uptake in the bone marrow in a patient who had undergone surgery for gastric antral gastrointestinal stromal tumor unrelated to the primary malignancy. The FDG-PET demonstrated diffusely enhanced uptake of the radiotracer in the vertebrae, pelvis, and the proximal long bones. The history revealed coexistent polycythemia rubra vera and multiple therapeutic phlebotomies in the past. There was no previous history of administration of chemotherapy or marrow stimulants, and bone marrow biopsy was negative for disease involvement. Bone marrow uptake of FDG in polycythemia rubra vera can be explained by bone marrow stimulation related to the clonal expansion of multipotent hematopoietic progenitor cell in this disease. Hence, such an entity should be considered in the differential diagnosis of marrow uptake of FDG in the absence of an attributable etiology.
Asymmetric F-18 Fluorocholine Uptake of Submaxillary Glands Revealing Intraglandular Lithiasis
Authors: F Clarençon, K Kerrou, F Gutman, D Chevallier, F Montravers, J N. Talbot
Journal: Clinical Nuclear Medicine (2007)

An 80-year-old man was referred to PET/CT using F-18 fluorocholine (FCH) for suspected recurrence of a localized prostatic adenocarcinoma treated by focused ultrasound therapy. The prostate-specific antigen (PSA) serum levels increased from 6.5 to 13.6 ng/mL over12 months. A total of 270 MBq of FCH (Iasocholine; Iason Laboratory, Graz, Austria) was intravenously injected. Abnormal uptake was seen in the prostate, favoring local recurrence. Physiological uptake occurred in the parotid glands and in the right submaxillary gland but was absent in the left submaxillary gland. The CT scan revealed 2 hyperdense round structures with calculi tonality located in the left submaxillary gland suggestive of intraglandular calcified lithiasis.
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
Authors: Jan Lammerding, P. Christian Schulze, Tomosaburo Takahashi, Serguei Kozlov, Teresa Sullivan, Roger D. Kamm, Colin L. Stewart, Richard T. Lee
Journal: Journal of Clinical Investigation (2004)

Mutations in the lamin A/C gene (LMNA) cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. The tissue-specific effects of lamin mutations are unclear, in part because the function of lamin A/C is incompletely defined, but the many muscle-specific phenotypes suggest that defective lamin A/C could increase cellular mechanical sensitivity. To investigate the role of lamin A/C in mechanotransduction, we subjected lamin A/C-deficient mouse embryo fibroblasts to mechanical strain and measured nuclear mechanical properties and strain-induced signaling. We found that Lmna-/- cells have increased nuclear deformation, defective mechanotransduction, and impaired viability under mechanical strain. NF-kappaB-regulated transcription in response to mechanical or cytokine stimulation was attenuated in Lmna-/- cells despite increased transcription factor binding. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription. These findings suggest that the tissue-specific effects of lamin A/C mutations observed in the laminopathies may arise from varying degrees of impaired nuclear mechanics and transcriptional activation.