tbuckley/cabot-search huggingface dataset:
Endocrine factors in pre- and postmenopausal women with hidradenitis Suppurativa
Authors: A.M. Farrel, R.P.R. Ddawber
Journal: British Journal of Dermatology (1997)

Journal Article Endocrine factors in pre‐ and postmenopausal women with hidradenitis Suppurativa Get access A.M. Farrel, A.M. Farrel Department of Dermatology, Chuirchill Hospital, Oxford 0X3 7Lj. U.K. Search for other works by this author on: Oxford Academic Google Scholar R.P.R. Ddawber R.P.R. Ddawber Department of Dermatology, Chuirchill Hospital, Oxford 0X3 7Lj. U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 5, 1 May 1997, Page 802, https://doi.org/10.1111/j.1365-2133.1997.tb03685.x Published: 01 May 1997
Outcomes of Pancreaticoduodenectomy
Authors: Erin G. Brown, Anthony Yang, Robert J. Canter, Richard J. Bold
Journal: JAMA Surgery (2014)

Changes in health care reimbursement policy have led to an era in which hospitals are motivated to improve quality of care while simultaneously reducing costs. Research demonstrating the most efficient means to target costs may have a positive effect on patient quality of life and the overburdened health care system.To evaluate the effect of hospital length of stay (LOS) and the occurrence of postoperative complications on total charges in patients undergoing elective pancreaticoduodenectomy.We performed a retrospective review of 89 cases identified in an institutional database of patients who underwent elective pancreaticoduodenectomy at an academic tertiary care center from December 1, 2007, through May 31, 2012.Occurrence of postoperative and inpatient complications, LOS, incidence of readmission within 60 days of discharge, and hospital charges from initial postoperative hospitalization. Linear regression analysis was performed comparing LOS with hospital charges.Thirty-four of 89 patients (38%) developed postoperative complications. Mean and median LOSs were 12 and 8 days, respectively. The LOS was significantly related to postoperative complications. Of the 34 patients who developed complications, the mean LOS was 19 days compared with 7 days for those patients not developing complications (P < .001). Only 2 of 55 patients (4%) without complications were readmitted to the hospital, whereas 13 of 34 patients (38%) with complications required readmission. Perioperative hospital charges were significantly related to LOS (R² = 0.840, R = 0.917). For those patients without complications, linear regression demonstrated a daily hospital charge of $11,612 (R² = 0.923, R = 0.961). However, for those patients with complications, the optimal relationship between LOS and hospital charges was exponential (R² = 0.832).Prolonged LOS is associated with increased total charges, but given the exponential increase in charges, the complication itself has an effect on increased charges above and beyond that of a prolonged hospitalization. The drive to reduce LOS after pancreaticoduodenectomy has minimal effect on overall charges to the patient. Efforts should be directed instead at reducing complications because this has a much more significant effect on financial outcomes.
Relationships between natural T cells, atopy, IgE levels, and IL‐4 production
Authors: A. Magnan, L. Mély, S. Prato, D. Vervloet, F. Romagné, C. Camilla, A. Necker, B. Casano, F. Montero‐Jullian, B. Malissen, P. Bongrand, V. Fert
Journal: Allergy (2000)

Background : Th2 cells govern allergic disorders. Mechanisms leading to the Th2 commitment are dominated by the requirement of IL‐4. A potential source of this triggering IL‐4 could be the CD4+ subset of a small population of T cells, natural T (NT) cells. Indeed, this subset is involved in IgE responses in mice and produces promptly high amounts of IL‐4 in both mice and man. Methods : NT cells were identified in peripheral blood by flow cytometry with antibodies against Vα24 and Vβ11, recognizing the T‐cell receptor specific for NT cells. Simultaneous staining with anti‐CD3, anti‐CD4, or anti‐CD8 antibodies was performed. The frequency of NT cells in man was studied according to the presence of atopy defined by the positivity of skin tests, according to total IgE levels in serum, and according to IL‐4 concentration of whole‐blood culture supernatants determined by a flow cytometer microsphere‐based assay. Results : Seventy subjects were included, of whom 30 were atopic. The number of CD4+ NT cells was higher in atopics than in nonatopics ( P =0.009). This number was correlated to the total IgE levels ( r =0.34, P =0.03). In addition, the number of CD4+ NT cells, but also of CD8+ NT cells, was correlated to the levels of IL‐4 ( r =0.71, P =0.01, and r =0.6, P =0.03, respectively). Conclusions : These results show that the number of NT cells, particularly the CD4+ subset, is related to atopy, IL‐4 production, and IgE levels. Therefore, this population of T cells is likely to play a role in the Th2 commitment initiating atopic diseases.
Interaction of liposomes with human epidermis reconstructed in vitro
Authors: H.C. KORTING, W. STOLZ, M.H. SCHMID, G. MAIERHOFER
Journal: British Journal of Dermatology (2006)

Upon topical application of liposomes of the large unilamellar vesicle type to human epidermis reconstructed in vitro, there is a dose‐dependent alteration of the morphology of both the stratum corneum and the living part of the epidermis. In particular. shrunken lipid droplets are found between corneocytes and keratinocytes, Sometimes, corneocytes show inclusions reminiscent of 'cholesterol crystals', Corneocytes, moreover, show a decreased density. Both corneocytes of the various layers of the stratum corneum and keratinocytes belonging to the uppermost layer of the living epidermis show particularly osmophilic membranes. indicating lipid transfer. Intact liposomes or their remnants can sometimes be seen between corneocytes of the upper strata, The presence of liposomal lipid within the stratum corneum is supported by the presence of gold particles used as a marker. There is, however, no evidence for the uptake of intact liposomes by the living epidermis, or their passage through this compartment of the skin.
REPORT OF A CASE OF GONORRHŒA WITH PURPURA RHEUMATICA.
Authors: W. A. PHILLIPS
Journal: JAMA (1889)

the disease is to-day more certain than our theory as to its origin, and if in the future a better ex¬ planation of the cause is offered than at present acceptable to the majority of accoucheurs, we do not hope for much change in the generally ac¬ cepted treatment.
Book Review Myelodysplastic Syndromes (Hematologic Malignancies.) Edited by H. Joachim Deeg, David T. Bowen, Steven D. Gore, Torsten Haferlach, Michelle M. Le Beau, and Charlotte Niemeyer. 139 pp., illustrated. Berlin, Springer-Verlag, 2006. $89.95. 3-540-26188-5
Authors: Miguel A. Sanz
Journal: New England Journal of Medicine (2006)
Radiology of Syndromes, Metabolic Disorders, and Skeletal Dysplasias
Authors: James E. Crowe
Journal: JAMA (1990)

When originally published in 1975,<i>Radiology of Syndromes</i>covered 540 syndromes, including metabolic disorders and skeletal dysplasias. The second edition, in 1983, was entitled<i>Radiology of Syndromes and Metabolic Disorders</i>, and included about 700 subjects. This new third edition has an expanded title,<i>Radiology of Syndromes, Metabolic Disorders, and Skeletal Dysplasias</i>, and an expanded text that covers nearly 1000 entities. This is a book by radiologists that is written primarily for radiologists. Part I (Syndromes) and Part II (Metabolic Disorders) are written by Dr Taybi, who has been collecting material about these disorders for the past 35 years. The information is extremely well organized. Each of the three parts is arranged in alphabetical order. The format used in most cases is that of a brief discussion of synonyms, mode of inheritance, frequency, clinical manifestations, radiological manifestations, and differential diagnosis. Descriptions vary from a few sentences to one or two pages.
Normal and pathologic biochemistry of the lung.
Authors: A B Fisher
Journal: Environmental Health Perspectives (1976)

The lung is an important metabolic organ. Glucose provides the major source of substrate. Oxidative pathways are active and are required to maintain normal tissue energy stores. Synthetic activity in the lung is extensive and related mainly to synthesis of dipalmitoyl lecithin and other components of the lung surfactant system. The lung plays an important role in the metabolism of xenobiotics and endogenous hormones leading to degradation as well as activation of important biologic properties.
A TWO-LOOP BUTTON SUTURE
Authors: W. G. Spencer
Journal: BMJ (1923)

A TWO-LOOP BUTTON SUTURE.I 969 and presented a somewhat nodular surface showing con- siderable congestion, and in places what appeared to be small areas of superficial ulceration.No marked resistaetce was offered to the knife.O'n section the tissue showed a solid core with a marked peripheral radiating structure which on microscopical examination was found to correspond to the hypertrophic adenomatous portion of the growth.
In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
Authors: Valéry Combes, Anne-Christine Simon, Georges-Emile Grau, Dominique Arnoux, Laurence Camoin, Florence Sabatier, Murielle Mutin, Marielle Sanmarco, José Sampol, Françoise Dignat-George
Journal: Journal of Clinical Investigation (1999)

Microparticles (MPs) resulting from vesiculation of platelets and other blood cells have been extensively documented in vitro and have been found in increased numbers in several vascular diseases, but little is known about MPs of endothelial origin. The aim of this study was to analyze morphological, immunological, and functional characteristics of MPs derived from human umbilical vein endothelial cells (HUVECs) stimulated by TNF, and to investigate whether these MPs are detectable in healthy individuals and in patients with a prothrombotic coagulation abnormality. Electron microscopy evidenced bleb formation on the membrane of TNF-stimulated HUVECs, leading to increased numbers of MPs released in the supernatant. These endothelial microparticles (EMPs) expressed the same antigenic determinants as the corresponding cell surface, both in resting and activated conditions. MPs derived from TNF-stimulated cells induced coagulation in vitro, via a tissue factor/factor VII-dependent pathway. The expression of E-selectin, ICAM-1, alphavbeta3, and PECAM-1 suggests that MPs have an adhesion potential in addition to their procoagulant activity. In patients, labeling with alphavbeta3 was selected to discriminate EMPs from those of other origins. We provide evidence that endothelial-derived MPs are detectable in normal human blood and are increased in patients with a coagulation abnormality characterized by the presence of lupus anticoagulant. Thus, MPs can be induced by TNF in vitro, and may participate in vivo in the dissemination of proadhesive and procoagulant activities in thrombotic disorders.
Benign strictures of the cervical oesophagus
Authors: P. M. Stell
Journal: Thorax (1973)

Four patients with a stricture of the cervical oesophagus are described. The stricture was hard and fibrotic and usually involved at least 2 cm of the oesophagus; there was no obvious cause of these strictures. Its management is described, using a local skin flap to replace the stenosed segment. This condition does not appear to have been described before.
Narcostimulation in Depressive States
Authors: J. S. NEKI, BALDEV KISHORE
Journal: American Journal of Psychiatry (1968)

Convulsive therapy is widely used in the treatment of depressive states; narcostimulation is a modified convulsive therapy which alternately produces narcosis and stimulation of the central nervous system. The authors used this method with 60 depressive patients in Amritsar, India, and achieved an over-all improvement rate of 68.3 percent, which compares favorably with other types of convulsive therapy.
Reduction of exercise-induced myocardial ischemia during add-on treatment with the angiotensin-converting enzyme inhibitor enalapril in patients with normal left ventricular function and optimal beta blockade
Authors: Ad F.M van den Heuvel, Peter H.J.M Dunselman, Tsjerk Kingma, Patrick Verhorst, Frans Boomsma, Wiek H van Gilst, Dirk J van Veldhuisen
Journal: Journal of the American College of Cardiology (2001)
Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome
Authors: Caroline Rooryck, Anna Diaz-Font, Daniel P S Osborn, Elyes Chabchoub, Victor Hernandez-Hernandez, Hanan Shamseldin, Joanna Kenny, Aoife Waters, Dagan Jenkins, Ali Al Kaissi, Gabriela F Leal, Bruno Dallapiccola, Franco Carnevale, Maria Bitner-Glindzicz, Melissa Lees, Raoul Hennekam, Philip Stanier, Alan J Burns, Hilde Peeters, Fowzan S Alkuraya, Philip L Beales
Journal: Nature Genetics (2011)
Controlled Striatal DOPA Production From a Gene Delivery System in a Rodent Model of Parkinson's Disease
Authors: Erik Cederfjäll, Lauren Broom, Deniz Kirik
Journal: Molecular Therapy (2015)

Conventional symptomatic treatment for Parkinson's disease (PD) with long-term L-3,4-dihydroxyphenylalanine (DOPA) is complicated with development of drug-induced side effects. In vivo viral vector-mediated gene expression encoding tyrosine hydroxylase (TH) and GTP cyclohydrolase 1 (GCH1) provides a drug delivery strategy of DOPA with distinct advantages over pharmacotherapy. Since the brain alterations made with current gene transfer techniques are irreversible, the therapeutic approaches taken to the clinic should preferably be controllable to match the needs of each individual during the course of their disease. We used a recently described tunable gene expression system based on the use of destabilized dihydrofolate reductase (DD) and generated a N-terminally coupled GCH1 enzyme (DD-GCH1) while the TH enzyme was constitutively expressed, packaged in adeno-associated viral (AAV) vectors. Expression of DD-GCH1 was regulated by the activating ligand trimethoprim (TMP) that crosses the blood-brain barrier. We show that the resulting intervention provides a TMP-dose-dependent regulation of DOPA synthesis that is closely linked to the magnitude of functional effects. Our data constitutes the first proof of principle for controlled reconstitution of dopamine capacity in the brain and suggests that such next-generation gene therapy strategies are now mature for preclinical development toward use in patients with PD.
Chinese medical journals: getting in touch
Authors: R. Smith
Journal: BMJ (1994)

guarantees inflation proofed income "of up to 85% of preinjury NHS earnings."The "up to" seems too vague.The quid pro quo for doctors complying with the guidelines should be that the financial sting should be removed for the very few who will remain positive for hepatitis B e antigen after their initial infection or treatment with interferon.Employers are responsible for offering vaccine to all relevant staff, and the guidelines point out that the costs of immunisation and follow up should be set against the
Abstract P2-14-04: Effect of age at the time of diagnosis on overall and cancer-specific mortality in breast cancer: Analysis of SEER, 1990-2008
Authors: J Bao, K-D Yu, Y-Z Jiang, G-H Di
Journal: Cancer Research (2013)

Abstract Background: As a critical factor, age at the time of diagnosis has a significant impact on cancer therapy and outcomes. The purpose of this study is to investigate the overall mortality (OM) and breast cancer-specific mortality (BCSM) in patients with breast cancer corresponding to age at the time of diagnosis, thus constructing an age-related pattern on breast cancer survival. Methods: We analyzed data for 396,978 women aged 20-79 from 1990 to 2008 diagnosed with breast cancer from the population-based Surveillance, Epidemiology, and End Results (SEER) program of the U.S. national cancer institute. Clinicopathological factors and outcomes were compared using a chi-square test, the Kaplan-Meier method, and Cox proportional hazards regression model. Results: In the multivariable analysis, a significant relationship was found between age at the time of diagnosis and OM (p&amp;lt;0.001) as well as BCSM (p&amp;lt;0.001). Using 70-79 years old as the reference, the hazard ratio (HR) of OM and BCSM presents a U-like shape with the bottom at the group 40-49 years old (OM: HR,0.56; P&amp;lt;0.001; BCSM: HR,0.58; p&amp;lt;0.001) and 50-59 years old (OM: HR,0.59; P&amp;lt;0.001;; BCSM: HR,0.60; p&amp;lt;0.001), increasing to both ends gradually. Analysis in subgroup according to ER and PgR status, group 20-29 years old showed no significant difference with group 70-79 years old on both OM and BCSM in all subgroups except on BCSM in ER+PR+ subgroup (HR,1.25; P = 0.002). Conclusion: Patients at very young and very old age (20-29 years old and 70-79 years old) have the poorest outcomes while prognosis improves with age towards mean level. The very young age (20-29 years old) may be regarded as a significant hazard factor for BCSM in patients with ER+PR+ breast cancer. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P2-14-04.
Radiological progression of rheumatoid arthritis in renal transplant recipients.
Authors: A Lamminen, T Pettersson, L Laasonen, B Kuhlback, J Edgren
Journal: Annals of the Rheumatic Diseases (1985)

Radiological progression of rheumatoid arthritis (RA) was evaluated retrospectively in eight patients with amyloidosis secondary to classical or definite RA and successful renal transplantation. Wrist joints, metacarpophalangeal, proximal interphalangeal, and metatarsophalangeal joints were graded on a scale from 0 to 5. The annual progression rate was calculated separately for the time before and after transplantation. A slight acceleration of the progression was observed after transplantation and is assumed to be due to activation of the rheumatoid disease when the azotaemia was corrected.
Angioplasty for coarctation of the aorta: long-term results.
Authors: R S Cooper, S B Ritter, W B Rothe, C K Chen, R Griepp, R J Golinko
Journal: Circulation (1987)

Balloon coarctation angioplasty (BCA) was performed in seven consecutive patients (five boys and two girls) 18 months to 18 years old (mean 9.5) with isolated discrete unoperated coarctation of the aorta. A No. 8F or 9F catheter was chosen with balloon lengths of 30 or 40 mm and maximum inflation diameters 1 mm less than the smallest measured aortic diameter determined 1 cm proximal to the coarctation site. A 10 sec inflation-deflation cycle of 6 to 8 atmospheres (90 to 120 psi) was performed. The peak systolic pressure gradient (PSG) before BCA ranged from 35 to 70 mm Hg (mean 58), and immediately after BCA it decreased to 0 to 20 mm Hg (mean 7). One to two year follow-up (mean 14 months) of the seven patients revealed a PSG range of 10 to 30 mm Hg (mean 19). Repeat angiography was performed immediately proximal to the coarctation site. Three patients (43%) had evidence of aneurysm formation at or immediately distal to the balloon dilatation site. One patient had coarctation restenosis. While initial results with BCA for unoperated coarctation were encouraging, current data raise serious concerns about its long-term safety and efficacy.
Diagnostic Value of Ten Systematic TRUS-Guided Prostate Biopsies
Authors: Vincent Ravery, Thierry Billebaud, Marianne Toublanc, Lilianne Boccon-Gibod, Jean-Fran&ccedil;ois Hermieu, Franck Moulinier, Emmanuel Blanc, Vincent Delmas, Laurent Boccon-Gibod
Journal: European Urology (1999)
Remarks ON SENSITIZATION AND DESENSITIZATION IN SKIN DISEASE
Authors: H. MacCormac
Journal: BMJ (1925)

Lastly, from a practical consideration of the subject of insanity, it is very necessary to recognize that the germ cells of every person wlho is certified as insane and sent to a mental hospital are not necessarily possible potential trans- mitters of a mental disease.General paralysis of the insane
Survey illustrates misconception of the Calman proposals
Authors: J N Johnson
Journal: BMJ (1995)

EDITOR,--In their survey of consultant physicians' attitudes to the Calman proposals Hugh M Mather and Robert S Elkeles show an important misconception about the nature of those proposals and the manner of their implementation.1 Nevertheless, we shall do well to heed the responses they obtained.

In summarising the Calman proposals the authors assume that what was envisaged was a service essentially provided by consultants resident on call. Indeed, they repeatedly refer to a “consultant provided service.” In fact, the Calman report referred only to a “consultant based service,” and, while I accept that neither of the two terms has been defined, I know, having been a member of the original working party, that emergency services …
EU clamps down on reimportation of cheap drugs meant for Africa
Authors: R. Watson
Journal: BMJ (2002)

The European Union is taking measures to prevent low cost drugs intended for patients in some of the world's poorest countries from being diverted and resold for huge profits in the West.

By clamping down on the illegal trade in reimported drugs that undercuts standard European prices, the EU is hoping to encourage pharmaceutical companies to expand the trend of making medicines available at special rates to the developing world.

The initiative comes amid growing evidence that cut price drugs are being diverted onto …
A Case of Haemorrhagic Pancreatitis
Authors: J. C. Uhthoff, E. F. Maynard
Journal: BMJ (1900)

There is considerable difficulty in keeping this organism alive, but it can be done by transplanting it on Loeffler's serum every three or four days, and keeping it constantly at 370 C. Cultures on Loeffler's serum kept at 370 C. were alive after fourteen days, and grew on transplantation.
Puffing Frequency and Nicotine Intake in Cigarette Smokers
Authors: H. Ashton, D. W. Watson
Journal: BMJ (1970)

<h3>Abstract</h3> <h3>Aims</h3> To generate a predictive model for the SARS-COV-2 viral reproductive rate, based on government policy and weather parameters. <h3>Methods</h3> A multivariate model for the log<sub>10</sub> of viral reproductive rate was constructed for each country using lockdown stringency (Oxford University tracker), temperature and humidity, for the 1<sup>st</sup> 110 days of 2020. This was validated by extrapolating to the following 51 days, and comparing the predicted viral rate and cumulative mortality with WHO data. The country models was extrapolated to July 2021 using projected weather forecast for four scenarios; continuing with the 11/6/2020 lockdown policy, 100% lockdown, 20% lockdown and no lockdown. <h3>Results</h3> From pooled data (40 countries), lockdown stringency had a strong negative correlation with log<sub>10</sub>viral reproductive rate (−0.648 at 21 days later). Maximum temperature correlated at −0.14, 14 days later and humidity correlated at +0.25, 22 days later. Predictive Models were generated for 11 countries using multivariate regression of these parameters. The R<sup>2</sup> correlation for log<sub>10</sub>R<sub>0</sub> ranged from 0.817 to 0.987 for the model generation period. For the validation period, the Pearson's coefficient of correlation for log<sub>10</sub>R<sub>0</sub> ranged from 0.529 to 0.984 and for cumulative mortality from 0.980 to 1.000. Forward extrapolation of these models for 5 nations, demonstrate, that removing the lockdown will result in rapid spread of the disease ranging from as soon as July 2020 for Russia, UK, Italy and India to January 2021 for the USA. The current (11/6/20) lockdown in the USA, Spain, UK, France, Germany, Turkey can control the disease but other nations will need to intensify their lockdowns to prevent future resurgence. Most nations will require more stringent lockdowns in January than in July. <h3>Conclusion</h3> The viral reproductive rate is highly predicted by a combination of lockdown stringency, temperature and humidity. Country specific predictive models can provide useful forecast of policy requirements.