Elevated International Normalized Ratio Associated with Trovafloxacin
Authors: Kavita Goel, Dhananjai Menzies, Burke A. Cunha
Journal: Annals of Internal Medicine (1999)

Letters6 July 1999Elevated International Normalized Ratio Associated with TrovafloxacinKavita Goel, MD, Dhananjai Menzies, MD, and Burke A. Cunha, MDKavita Goel, MDWinthrop-University Hospital; Mineola, NY 11501 (Goel)Winthrop-University Hospital; Mineola, NY 11501 (Menzies)Winthrop-University Hospital; Mineola, NY 11501 (Cunha)Search for more papers by this author, Dhananjai Menzies, MDWinthrop-University Hospital; Mineola, NY 11501 (Goel)Winthrop-University Hospital; Mineola, NY 11501 (Menzies)Winthrop-University Hospital; Mineola, NY 11501 (Cunha)Search for more papers by this author, and Burke A. Cunha, MDWinthrop-University Hospital; Mineola, NY 11501 (Goel)Winthrop-University Hospital; Mineola, NY 11501 (Menzies)Winthrop-University Hospital; Mineola, NY 11501 (Cunha)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-1-199907060-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The international normalized ratio (INR [normal ≤ 1.0]) may become elevated in patients receiving trovafloxacin. We report four cases of elevated INR related to trovafloxacin.Case 1: A 69-year-old woman was admitted with recurrent nephrolithiasis. At admission, her INR was normal. She was treated with cefepime for presumed pneumonia, but her condition worsened. Cefepime therapy was discontinued, and intravenous trovafloxacin therapy, 200 mg every 24 hours, was started. After 3 days of trovafloxacin treatment, her INR markedly increased to 5.26. Trovafloxacin therapy was discontinued, and her INR returned to normal in 3 days.Case 2: A 29-year-old ...References1. Brighty KE, Gootz TD. The chemistry and biological profile of trovafloxacin. J Antimicrob Agent Chemother. 1997;39 Suppl B 1-14. CrossrefMedlineGoogle Scholar2. Dalvie DK, Khosla N, Vincent J. Excretion and metabolism of trovafloxacin in humans. Drug Metab Dispos. 1997;25:423-7. MedlineGoogle Scholar3. O'Reilly RA. Drugs used in disorders of coagulation.. In: Katzung B, eds. Basic and Clinical Pharmacology. Stamford, CT: Appleton & Lange; 1998:50-61. Google Scholar4. Brown RB, Klar J, Teres D, Lemeshow S, Sands M. Prospective study of clinical bleeding in intensive care unit patients. Crit Care Med. 1988;16:1171-6. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Winthrop-University Hospital; Mineola, NY 11501 (Goel)Winthrop-University Hospital; Mineola, NY 11501 (Menzies)Winthrop-University Hospital; Mineola, NY 11501 (Cunha) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIdiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin HepatotoxicityTrovafloxacin 6 July 1999Volume 131, Issue 1Page: 72KeywordsAspirinAttentionBlood plasmaCellulitisHemorrhageInternational normalized ratioIschemiaMyocardial infarctionPneumoniaVitamin K Issue Published: 6 July 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...