tbuckley/cabot-search huggingface dataset:
Isolated Cases of Vibrio parahaemolyticus Gastroenteritis
Authors: Fredy P. Roland
Journal: JAMA (1979)

To the Editor.—  Since 1969 Vibrio parahaemolyticus has caused 16 gastroenteritis food-borne outbreaks, with two aboard cruise ships (237:1980, 1977). Isolated cases of V parahaemolyticus gastroenteritis are unusual. One case concerned a man who had eaten exotic Japanese seafood (236:822, 1976).  Report of a Case.—  The day after returning from a trip on one of the Massachusetts Coast islands, a 57-year-old woman had abdominal cramps with severe diarrhea, no vomiting, and no fever. The stools had no blood or mucus. She had eaten seafood, including clams and snails. The stool showed V parahaemolyticus in pure culture on sodium chloride-added xylose lysine deoxycholate agar. 1 The V parahaemolyticus antimicrobial susceptibility tests on Mueller-Hinton agar with 1.00% sodium chloride added was sensitive to ampicillin, tetracycline, gentamicin, and chloramphenicol, and resistant to penicillin, carbenicillin, and cephalothin.  The patient was treated with ampicillin; V parahaemolyticus disappeared from the stools in six days, and she
Injuries in professional motor car racing drivers at a racing circuit between 1996 and 2000
Authors: O Minoyama, H Tsuchida
Journal: British Journal of Sports Medicine (2004)

Research on injuries in racing drivers is limited.To gain more information about such injuries.Injuries recorded during and after races between 1996 and 2000 were investigated using the medical charts from the circuit medical centre at Fuji Speedway, which is one of the biggest circuits in Japan. Races were in either single seat/formula cars or saloon cars.Data were obtained from 39 races in single seat cars (1030 participating cars) and 42 races in saloon cars (1577 cars). Fifty injuries were recorded during the single seat car races, and 62 during the saloon car races (injury rate 1.2 per 1000 competitors per race and 0.9 per 1000 competitors per race respectively). Thirteen injuries were recorded after the race, 12 of them in saloon car racing. Bruises were the major injury in single seat car racing (58%). Lower limb bruising was more common than upper limb bruising. Most of the injuries in saloon car racing (53.2%) were neck sprains. The incidence of concussion was high in both groups compared with other high risk sports.There were some differences in injuries between the two types of car. No serious injuries occurred except for one death. However, the driver's body is subjected to large forces in a crash, hence the high incidence of concussion. The injuries recorded after the race emphasise that motor racing is a demanding sport.
Hermaphroditism, Genital Anomalies and Related Endocrine Disorders
Authors: Robert W. Kistner
Journal: JAMA (1972)

The second edition of this text has been anxiously awaited by specialists in the fields of gynecology, urology, pediatrics, and cytogenetics. They will be pleased with the up-dated and revised product. An understanding of intersexuality and its associated problems has taken on new and important significance. During the last decade, more advances have been made in clarifying the precise etiologic factors causing anomalies of sexual differentiation than in any other 10-year span in medical history. The field of cytogenetics alone has revolutionized basic concepts of these disorders.  The expanding scope of intersexuality has necessitated the addition of contributors who are recognized authorities in their specific fields; their observations reflect extensive personal experience and backgrounds of both basic and clinical science. This joint effort provides a comprehensive, authoritative, and current compendium of the subject that cannot be found elsewhere.  In the preface to the second edition, the authors state that, except
An alternative path to the cecum: nicorandil-associated diverticular sigmoido-cecal fistula
Authors: G. Ramos, J. Coimbra, J. Barreiras, A. Marques
Journal: Endoscopy (2011)

Colonic fistulas are rare and, in patients without inflammatory bowel disease or neoplasia, are usually related to complicated appendicitis or diverticulitis. We report a case of sigmoido-cecal fistula with no known history of ileocolonic disease.
Improved tumor imaging and therapy via i.v. IgG–mediated time-sequential modulation of neonatal Fc receptor
Authors: Jaspreet Singh Jaggi, Jorge A. Carrasquillo, Surya V. Seshan, Pat Zanzonico, Erik Henke, Andrew Nagel, Jazmin Schwartz, Brad Beattie, Barry J. Kappel, Debjit Chattopadhyay, Jing Xiao, George Sgouros, Steven M. Larson, David A. Scheinberg
Journal: Journal of Clinical Investigation (2007)

The long plasma half-life of IgG, while allowing for enhanced tumor uptake of tumor-targeted IgG conjugates, also results in increased background activity and normal-tissue toxicity. Therefore, successful therapeutic uses of conjugated antibodies have been limited to the highly sensitive and readily accessible hematopoietic tumors. We report a therapeutic strategy to beneficially alter the pharmacokinetics of IgG antibodies via pharmacological inhibition of the neonatal Fc receptor (FcRn) using high-dose IgG therapy. IgG-treated mice displayed enhanced blood and whole-body clearance of radioactivity, resulting in better tumor-to-blood image contrast and protection of normal tissue from radiation. Tumor uptake and the resultant therapeutic response was unaltered. Furthermore, we demonstrated the use of this approach for imaging of tumors in humans and discuss its potential applications in cancer imaging and therapy. The ability to reduce the serum persistence of conjugated IgG antibodies after their infusion can enhance their therapeutic index, resulting in improved therapeutic and diagnostic efficacy.
The Frey Procedure Is a Treatment for Chronic Pancreatitis, Not Pancreas Divisum
Authors: Bharath D. Nath, Steven D. Freedman, A. James Moser
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Conference Report: Art and the NHS
Authors: T. Richards
Journal: BMJ (1983)

Each year more people pass through the doors of St Thomas's Hospital than through the Tate Gallery-a thought provoking comment, and one of many made at a recent meeting on art and the NHS, organised by the DHSS and held at the King's Fund Centre.The impetus came from a seminar held at the Institute of Contemporary Arts last year, where one of the topics was art in hospitals.This stimulated so much discussion that the DHSS was moved to commission Peter Coles to look at art in NHS buildings on a national scale, and his findings provided the basis for the current meeting.There was passionate support for the arts, a plea to "stop regarding art as a frill and accept its central role in improving the visual and social en- vironment of our hospitals," illustrations of specific art projects, and a dash of practical advice.No one disagreed with the basic premise that it is desirable to make our hospitals "less awesome and drab," nor the scathing description of postwar architectfire.The major role of the hospital in public life was discussed: it was even suggested that it might be the "twentieth century equivalent of the cathedral."Professor John Davies reminded us that major life events- birth, sickness, and death (not to mention the less dramatic burden of chronic ill health and disability)-take place within its walls.Hospitals should therefore seek to improve the quality of life for both patients and staff by creating an atmos- phere of health and optimism rather than sterile practicality.The idea that quality of life should be subjected to some form of cost effective audit was thankfully squashed before it got off the ground.So what has been done so far ?Over 65 hospitals in Britain set aside money to buy works of art and many obtain paintings on loan from local authorities.There was broad agreement that original and contemporary paintings were more desirable than hackneyed reproductions of old masters.A few hospitals employ artists as permanent members of staff to broaden the scope of art beyond the visual to include the performing arts, and to stimulate patient and staff participation in art projects.SHAPE was set up in 1976 to promote arts activities for the disabled, elderly, and mentally handicapped.Progress on the arts in hospitals is a patchy affair, but an idea of what can be achieved was given by speakers describing individual hospital projects.Glynn Purland (senior administrator, Queen's Medical Centre, Nottingham) showed some illuminating before and after slides and convinced his audience that miles of corridor and characterless spaces can be given a personality by imaginative decoration.On a practical note he mentioned that "art" is a "fabric protector" because it inhibits people from barging into walls.Peter Senior (director and founder of the Manchester Hospitals Art Project) showed how the hospital environment in his area has been transformed by the arts team.From puppet shows to chamber music, macrame
Abstract 1491: Downregulation of KLF5 contributes to TGF-β- and EGF-induced EMT by reducing miR-200s.
Authors: Baotong Zhang, Jin-tang Dong
Journal: Cancer Research (2013)

Abstract Krüpple-like factor 5 (KLF5) is a basic transcriptional factor that has been well documented for its regulatory role in the proliferation and survival of epithelial cells. Recently, bioinformatic analysis suggests that KLF5 also regulates epithelial-to-mesenchymal transition (EMT), yet experimental evidence is still lacking regarding whether and how KLF5 regulates EMT. As a form of epithelial cell plasticity, EMT can be induced by many cytokines including TGF-β and EGF. Here we report a role of KLF5 in EMT. We found that KLF5 was significantly down-regulated during TGF-β- and EGF-induced EMT in epithelial cells including HaCaT cells, MCF-10A cells, and mouse primary keratinocytes; and that silencing KLF5 induced EMT as well, as indicated by altered cell morphology, enhanced migration, upregulation of CDH2, FN1 and ZEB1, dislocation of CDH1 from cell-cell junctions, and induction of actin fibers. To determine whether miRNAs mediate the role of KLF5 in EMT, a real-time qPCR assay was employed to search for miRNAs regulated by KLF5 during EMT. Five members of the miR-200 family, all of which have been implicated in EMT, were found to be down-regulated upon the downregulation of KLF5. KLF5 directly regulated the expression of miR-200s by binding to the GC boxes of their promoters, as demonstrated by functional and biochemical analyses including luciferase reporter assay, ChIP-PCR assay, and oligo pull-down assay. Functionally, overexpression of miR-200s inhibited EMT induced by KLF5 silencing or TGF-β and EGF treatment in HaCaT cells, and forced expression of KLF5 attenuated TGF-β- and EGF-induced EMT by rescuing miR-200s expression. To evaluate whether the KLF5-miR-200s axis modulates EMT in vivo, we determined the expression of Klf5, miR-200s and EMT markers in knockout mice and human breast cancer specimens. In mouse prostate neoplasms induced by Pten deletion, knockout of Klf5 repressed the expression of miR-200s and induced the downregulation of CDH1 and upregualtion of vimentin, which are indicative of EMT. Expression of KLF5 also correlated with miR-200s at the RNA level in human breast cancer specimens. These findings suggest that KLF5 directly regulates the transcription of miR-200s in epithelial cells, and that downregulation of the KLF5-miR-200 axis plays a causal role in TGF-β- and EGF-induced EMT, providing new insights into the regulation of EMT. Citation Format: Baotong Zhang, Jin-tang Dong. Downregulation of KLF5 contributes to TGF-β- and EGF-induced EMT by reducing miR-200s. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1491. doi:10.1158/1538-7445.AM2013-1491
Dynamic processes involved in the pre-vascularization of silk fibroin constructs for bone regeneration using outgrowth endothelial cells
Authors: Sabine Fuchs, Xin Jiang, Harald Schmidt, Eva Dohle, Shahram Ghanaati, Carina Orth, Alexander Hofmann, Antonella Motta, Claudio Migliaresi, Charles J. Kirkpatrick
Journal: Biomaterials (2008)
Confounding in clinical trials
Authors: P. Sedgwick
Journal: BMJ (2012)

Researchers investigated whether a low glycaemic index diet in pregnancy reduced the incidence of macrosomia—babies large for their gestational age—in an at-risk group. A randomised controlled trial study design was used. The intervention was a low glycaemic index diet from early pregnancy. The control group received no dietary intervention. Participants were women without diabetes, aged 18 or over, all in their second pregnancy between January 2007 and January 2011, and who had previously delivered an infant weighing more than 4 kg. In total, 800 women were recruited, of whom 396 were randomised to intervention and 404 to control.1 The primary outcome was birth weight. Of the 396 women allocated to intervention, 372 (93.9%) provided data at follow-up, compared with 387 (95.8%) of the 404 women allocated to control. A per protocol analysis was performed. No significant difference existed between treatments in absolute birth weight, birthweight centile, or ponderal index. Which of the following statements, if any, are true?
Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage
Authors: Atsuko Kamijo, Kenjiro Kimura, Takeshi Sugaya, Masaya Yamanouchi, Hiromi Hase, Tomoyo Kaneko, Yasunobu Hirata, Atsuo Goto, Toshiro Fujita, Masao Omata
Journal: Kidney International (2002)
Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth
Authors: María Angeles Abéngozar, Sergio de Frutos, Sergio Ferreiro, Joaquím Soriano, Manuel Perez-Martinez, David Olmeda, Marco Marenchino, Marta Cañamero, Sagrario Ortega, Diego Megias, Antonio Rodriguez, Jorge L. Martínez-Torrecuadrada
Journal: Blood (2012)
Genetic variants in the noncoding region of <i>RPS19</i> gene in Diamond‐Blackfan anemia: Potential implications for phenotypic heterogeneity
Authors: Aurore Crétien, Alexis Proust, Jean Delaunay, Patricia Rincé, Thierry Leblanc, Rolande Ducrocq, Maud Simansour, Isabelle Marie, Hannah Tamary, Jörg Meerpohl, Charlotte Niemeyer, Hanna Gazda, Colin Sieff, Sarah Ball, Gil Tchernia, Narla Mohandas, Lydie Da Costa
Journal: American Journal of Hematology (2009)

Mutations in the RPS19 gene have been identified in 25% of individuals affected by Diamond-Blackfan anemia (DBA), a congenital erythroblastopenia characterized by an aregenerative anemia and a variety of malformations. More than 60 mutations in the five coding exons of RPS19 have been described to date. We previously reported a mutation (c.-1 + 26G>T) and an insertion at -631 upstream of ATG (c.-147_-146insGCCA) in the noncoding region. Because DBA phenotype is extremely heterogeneous from silent to severe and because haploinsufficiency seems to play a role in this process, it is likely that genetic variations in the noncoding regions affecting translation of RPS19 can modulate the phenotypic expression of DBA. However, to date, very few studies have addressed this question comprehensively. In this study, we performed detailed sequence analysis of the RPS19 gene in 239 patients with DBA and 110 of their relatives. We found that 6.2% of the patients with DBA carried allelic variations upstream of ATG: 3.3% with c.-1 + 26G>T; 2.5% with c.-147_-146insGCCA; and 0.4% with c.-174G>A. Interestingly, the c.-147_-146insGCCA, which has been found in a black American and French Caribbean control population, was not found in 500 Caucasian control chromosomes we studied. However, it was found in association with the same haplotype distribution of four intronic polymorphisms in our patients with DBA. Although a polymorphism, the frequency of this variant in the patients with DBA and its association with the same haplotype raises the possibility that this polymorphism and the other genetic variations in the noncoding region could play a role in DBA pathogenesis.
Esophageal moniliasis. The spectrum of the disease
Authors: D. J. Sheft
Journal: JAMA (1970)

Candida albicans<i>is a saprophytic organism under normal circumstances and a limited pathogen when present in large numbers. With impaired defense mechanisms, however, or long-term antibiotic therapy, it can become a significant pathogen. The clinical symptoms and roentgenographic findings present a spectrum of changes depending on the degree of esophageal involvement. Painful swallowing or substernal chest pain are the most common symptoms. Roentgenographic study reveals changes varying from minor mucosal irregularities and submucosal edema to extensive ulcerations. Roentgenographic examination of the esophagus is a useful method for establishment of the diagnosis.</i>
A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia.
Authors: P Curtin, M Pirastu, Y W Kan, J A Gobert-Jones, A D Stephens, H Lehmann
Journal: Journal of Clinical Investigation (1985)

We describe an English family with an atypical gamma delta beta-thalassemia syndrome. Heterozygosity results in a beta-thalassemia phenotype with normal hemoglobin A2. However, unlike previously described cases, no history of neonatal hemolytic anemia requiring blood transfusion was obtained. Gene mapping showed a deletion that extended from the third exon of the G gamma-globin gene upstream for approximately 100 kilobases (kb). The A gamma-globin, psi beta-, delta-, and beta-globin genes in cis remained intact. The malfunction of the beta-globin gene on a chromosome in which the deletion is located 25 kb away suggests that chromatin structure and conformation are important for globin gene expression.
Ethics guidelines for research with the recently dead
Authors: Rebecca D Pentz, Cynthia B Cohen, Mark Wicclair, Michael A DeVita, Anne Lederman Flamm, Stuart J Youngner, Ann B Hamric, Mary S McCabe, Jacqueline J Glover, Winona J Kittiko, Kathy Kinlaw, James Keller, Adrienne Asch, John J Kavanagh, Wadih Arap
Journal: Nature Medicine (2005)
A SYSTEM OF WEIGHED HIGH CARBOHYDRATE DIETS FOR DIABETES
Authors: JAMES J. SHORT
Journal: JAMA (1931)

Following the report of Sansum's<sup>1</sup>encouraging experiences in the use of relatively high carbohydrate fat ratios in the dietetic management of diabetes, some preliminary observations with similar diets were made in the summer of 1928 in the medical wards and in the metabolic clinic of the New York Post-Graduate Hospital. The early results were so promising as to warrant the continued use of such ratios, and a simple and convenient system of diets thus became necessary. Those produced herewith were compiled, and during two years of use they have proved highly satisfactory. The general arrangement is the same as that first employed by Mosenthal<sup>2</sup>in the preparation of diabetic diets based on the Woodyatt<sup>3</sup>formulas. Six diets are presented. A summary of the carbohydrate, protein and fat content of each, together with its caloric value, is appended to the left for ready reference. The food amounts are
Poliomyelitis — Newberry County, South Carolina, 1961
Authors: James A. Bryan
Journal: JAMA (1963)

In 1961, Newberry County, South Carolina, reported more clinically recognized cases of poliomyelitis than ever before noted in that area. A total of 24 cases caused by Type 3 poliomyelitis virus were recognized; the rate of attack for the country was 83 per 100,000 persons. The epidemiological pattern of age and race involvement in this outbreak differed from previous experiences with poliomyelitis in South Carolina in that Negro children of school age were predominantly involved. It is suggested that personal contact through the Negro elementary school was a major factor in viral spread. The extent to which inactivated (Salk) poliomyelitis vaccine had been used varied between the Negro and other segments of the community. Only 2 of the 24 patients involved had received as many as 3 doses of inactivated vaccine.
Physiological responses to increased dietary cholesterol: The case of the egg man
Authors: Jorge J. Gumucio, Michael P. Jones, Douglas M. Heuman
Journal: Hepatology (1991)

An 88-yr-old man carrying the tentative diagnosis of Alzheimer’s disease had a documented history of ingesting 20 to 30 eggs/day for approximately 15 yr. His psychiatrist characterized his eating habits as a compulsive disorder:“Eating these eggs ruins my life, but I can’t help it.” He is in excellent health. His weight is constant at 82 to 86 kg (height 1.87 m). Apparently, he had a mild episode of angina. Otherwise, no significant history of stroke, heart disease or gallbladder disease was seen. His serum cholesterol levels have ranged between 150 and 200 mg/dl.
Anesthetic Implications of Congenital Anomalies in Children
Authors: Maxine T. Clarke
Journal: JAMA (1981)

The principal authors of this small reference text indicate that two concepts have been emphasized in the preparation of the work: (1) that the presence of one congenital anomaly should prompt a search for others and (2) that the book is designed to present some of the principles of anesthetic management in children with congenital anomalies, not to serve as a textbook of pediatric anesthesiology. The first concept should already be familiar to anesthesiologists. Regarding the second, this reviewer's opinion is that the book, as it has finally evolved, falls somewhere between the management principle and textbook genres and in this divisiveness loses the vigor, originality, and cohesiveness implicit in its title. Fourteen contributors in addition to Dr Stehling have written the book's 12 chapters. These anesthesiologists and their departments are among North America's most distinguished, and what they have submitted is, of course, correct and useful. But this is
Aureomycin in the Prophylaxis of Rheumatic Fever
Authors: Leon V. McVay, Douglas H. Sprunt
Journal: New England Journal of Medicine (1953)

DESPITE recent progress, the prevention of rheumatic fever remains a challenging problem. The investigation of this subject is made difficult by the lack of basic knowledge concerning the disease itself.1 Rheumatic fever is widely recognized as a frequent and potentially serious condition; yet its actual incidence cannot be accurately determined.2 Frequently, the clinical picture is quite atypical: there may be no arthritis or arthralgia; and the disease may be extremely severe or very mild. No precise diagnostic procedure is available.3 Doubtless, therefore, numerous cases are overlooked and misdiagnosed. Even so, it is estimated that 200,000 to 250,000 persons in the . . .
Increased fibrinolytic activity in venous blood of hemiplegic limbs.
Authors: I. S. Menon, H. A. Dewar
Journal: BMJ (1967)

Twenty-seven patients with Ehlers-Danlos syndrome belong- ing to 15 families were examined.Three distinct familial clinical types were found-" classical," "varicose," and " arterial."A new hypothesis regarding the basic defect(s) in "Ehlers-Danlos syndrome is discussed.