tbuckley/cabot-search huggingface dataset:
Late Outcomes of Reintervention on the Descending Aorta After Repair of Aortic Coarctation
Authors: Morgan L. Brown, Harold M. Burkhart, Heidi M. Connolly, Joseph A. Dearani, Donald J. Hagler, Hartzell V. Schaff
Journal: Circulation (2010)

After repair of aortic coarctation, patients may develop restenosis, aneurysms, and pseudoaneurysms at the site of prior repair. We assessed the outcomes of late reintervention on the descending aorta after aortic coarctation repair.From March 1954 to July 2008, 130 patients had operations or endovascular procedures on the descending aorta after previous coarctation repair. We excluded patients who had complex left-sided cardiac lesions or interrupted aortic arch. Mean age at reintervention was 32±24 years and 28% were female. The interval between coarctation repair and reintervention was 17±13 years. Seventy-four percent of patients had hypertension. Reasons for reintervention were restenosis (n=122 [94%]), aneurysm (n=4 [3%]), and pseudoaneurysm (n=4 [3%]). Ninety-five patients (73%) underwent operative procedures including an extra-anatomic conduit (n=41), patch repair (n=32), interposition graft (n=14), end-end anastomosis (n=6), and subclavian flap (n=2). Thirty-five patients underwent endovascular treatment (balloon dilatation, n=22 or stenting, n=13). There was no early mortality. In the surgical group, 5 patients required early reoperation for bleeding and 5 patients had early vocal cord paralysis. One patient in the endovascular group had aortic rupture at the time of intervention requiring urgent operation. Survival was 97% at 10 years. At 5 years, freedom from a second repeat procedure on the descending aorta was 96% in the surgical group and 72% in the endovascular group (P<0.001). Five years after reintervention, fewer patients required treatment for hypertension (57% versus 74%, P<0.001) and a median of 1 antihypertensive medication was prescribed compared with a median of 2 medications preintervention.Operative and endovascular management of recoarctation can be performed safely with good late outcomes.
Renin-angiotensin system in neonatal rats: Induction of a renal abnormality in response to ACE inhibition or angiotensin II antagonism
Authors: Peter Friberg, Birgitta Sundelin, Sven-Olof Bohman, Alexander Bobik, Holger Nilsson, Anna Wickman, Helena Gustafsson, John Petersen, Michael A. Adams
Journal: Kidney International (1994)
Spirituality and Chronic Illness
Authors: Timothy P. Daaleman
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Compensatory Adjustments in the Structure of Coronary Arteries of the Heart with Stenotic Atherosclerosis
Authors: N. N. ANITSCHKOW, K. G. WOLKOFF, E. E. KIKAION, K. M. POZHARISSKI
Journal: Circulation (1964)

Adjustments within the coronary arterial system that compensate for stenotic atherosclerosis include hypertrophy of larger coronary arterial branches unaffected by atherosclerosis that undertake supply of blood to an anemic myocardial area; development of collateral circulation; extension of the "paravasal" bed; formation of short anastomoses; and wide recanalization of thrombi. A combination of special technics devised for this investigation included fixation of coronary arteries with formol under pressure approximating the level of diastolic blood pressure, followed by their injection with an opaque mixture or colored gelatin; angiographic examination and dissection; and microscopic examination of numerous cross sections prepared from the whole length of major trunks and their branches. The size of atherosclerotic plaques and degree of luminal narrowing were then determined planimetrically, as a percentage of the original lumen. These studies yielded objective evidence for assessing the influence exerted by varying degrees of luminal narrowing on blood supply to myocardium as well as on development of intercoronary anastomoses, and their compensatory significance. The principal conditions bringing about insufficiency of compensatory adjustments have also been considered: progression of coronary atherosclerosis involving arterial anastomoses in the process; successive deposition of lipids over the walls of wide channels through organized thrombi, resulting in their occlusion due to secondary thrombosis; and individually inadequate development of compensatory adjustments.
Near fatal eosinophilic gastroenteritis responding to oral sodium chromoglycate.
Authors: R J Moots, P Prouse, J M Gumpel
Journal: Gut (1988)

Eosinophilic gastroenteritis (EG) is an uncommon disorder, characterised by cramping abdominal pain, diarrhoea and vomiting and histologically by eosinophilic infiltration of bowel wall. We present a patient who developed EG during the course of a systemic, necrotising vasculitis, who became critically ill after failure of treatment with corticosteroids and cytotoxic drugs and responded only to oral sodium chromoglycate.
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation
Authors: Deborah Chiabrando, Samuele Marro, Sonia Mercurio, Carlotta Giorgi, Sara Petrillo, Francesca Vinchi, Veronica Fiorito, Sharmila Fagoonee, Annalisa Camporeale, Emilia Turco, Giorgio R. Merlo, Lorenzo Silengo, Fiorella Altruda, Paolo Pinton, Emanuela Tolosano
Journal: Journal of Clinical Investigation (2012)

Feline leukemia virus subgroup C receptor 1 (FLVCR1) is a cell membrane heme exporter that maintains the balance between heme levels and globin synthesis in erythroid precursors. It was previously shown that Flvcr1-null mice died in utero due to a failure of erythropoiesis. Here, we identify Flvcr1b, a mitochondrial Flvcr1 isoform that promotes heme efflux into the cytoplasm. Flvcr1b overexpression promoted heme synthesis and in vitro erythroid differentiation, whereas silencing of Flvcr1b caused mitochondrial heme accumulation and termination of erythroid differentiation. Furthermore, mice lacking the plasma membrane isoform (Flvcr1a) but expressing Flvcr1b had normal erythropoiesis, but exhibited hemorrhages, edema, and skeletal abnormalities. Thus, FLVCR1b regulates erythropoiesis by controlling mitochondrial heme efflux, whereas FLVCR1a expression is required to prevent hemorrhages and edema. The aberrant expression of Flvcr1 isoforms may play a role in the pathogenesis of disorders characterized by an imbalance between heme and globin synthesis.
Teaching Materia Medica.
Authors: E. B. Borland
Journal: JAMA (1897)

Pittsburg, Pa., May 3, 1897. <h3>To the Editor:</h3> —So many physiologic actions are accredited to each agent in the text books on materia medica that the average student does not know the difference between the important or leading actions and those of minor importance. If you ask a recent graduate from any medical school to name the five most important physiologic actions of the common drug, opium, he will probably be unable to correctly answer in a majority of cases. Personal observation, rather than rumor, justifies this statement. The lack of this essential knowledge of the important drugs is to be deplored; and its remedy should engage the attention of all medical teachers. The great majority of medical graduates know little of pharmacy and less of materica medica. They enter practice and waste their lives writing original package prescriptions. In teaching this important branch too many agents are studied and
Metals in some lagoons of Mexico.
Authors: F G Vazquez, V K Sharma, V H Alexander, C A Frausto
Journal: Environmental Health Perspectives (1995)

The concentrations of metals, Cd, Cu, Fe, Mn, Ni, Pb, and Zn were determined in some lagoons to establish the level of metal pollution. The lagoons studied were Alvarado lagoon, Veracruz; San Andres lagoon, Tamaulipas; and Terminos lagoon, Campeche. The concentrations were determined in water, oyster (Crassostrea virginica), and sediments. Metals were accumulated in either oysters or sediments. Cu and Zn were higher in oysters and Fe and Mn were higher in sediments. The results in water samples were compared with the limit established by the Secretaria de Ecologia and Desarrollo Urbano Report and briefly discussed.
An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia
Authors: Klaus H. Metzeler, Manuela Hummel, Clara D. Bloomfield, Karsten Spiekermann, Jan Braess, Maria-Cristina Sauerland, Achim Heinecke, Michael Radmacher, Guido Marcucci, Susan P. Whitman, Kati Maharry, Peter Paschka, Richard A. Larson, Wolfgang E. Berdel, Thomas Büchner, Bernhard Wörmann, Ulrich Mansmann, Wolfgang Hiddemann, Stefan K. Bohlander, Christian Buske
Journal: Blood (2008)
Low molecular weight heparin (reviparin) in percutaneous transluminal coronary angioplasty results of a randomized, double-blind, unfractionated heparin and placebo-controlled, multicenter trial (REDUCE trial)
Authors: Karl R. Karsch, Melitta B. Preisack, Rainer Baildon, Volker Eschenfelder, David Foley, Eulogio J. Garcia, Martin Kaltenbach, Christoph Meisner, Hans K. Selbmann, Patrick W. Serruys, Man F. Shiu, Martin Sujatta, Raoul Bonan
Journal: Journal of the American College of Cardiology (1996)
INTERNAL EAR DEAFNESS, ILLUSTRATED.
Authors: J. G. CARPENTER
Journal: JAMA (1889)

The theme of labyrinthian deafness is one of very great interest, because it is so often incurable, and is generally secondary to, or the sequel of many affections; and to cure the disease, the ailment on which it depends must be cured, the pathological lesions removed, before irreparable structural changes have taken place in the inner ear. The premises will be made in this paper that internal ear disease is dependent more often on middle ear disease, and the latter, most frequently dependent on chronic nasopharyngeal catarrh, for the predisposing cause, and acute congestion or acute inflammation of the upper respiratory tract and aural apparatus, for the exciting cause; making due allowance, of course, for other etiological factors. Experience and observation teach the writer that doubtless chronic nasopharyngeal catarrh is present in the majority of such cases; is the most frequent of all other causes; and, if the previous history
Injectable Fibrin Scaffold Improves Cell Transplant Survival, Reduces Infarct Expansion, and Induces Neovasculature Formation in Ischemic Myocardium
Authors: Karen L. Christman, Andrew J. Vardanian, Qizhi Fang, Richard E. Sievers, Hubert H. Fok, Randall J. Lee
Journal: Journal of the American College of Cardiology (2004)
Serum 25-dihydroxyvitamin D levels correlate with CD4+Foxp3+ T-cell numbers in moderate/severe asthma
Authors: Emma S. Chambers, Alexandra M. Nanzer, David F. Richards, Kimuli Ryanna, Anna T. Freeman, Peter M. Timms, Adrian R. Martineau, Christopher J. Griffiths, Christopher J. Corrigan, Catherine M. Hawrylowicz
Journal: Journal of Allergy and Clinical Immunology (2012)
Hemoglobin dhonburi α<sub>2</sub>β<sub>2</sub> 126 (H4) Val → Gly: A new unstable β variant producing a β‐thalassemia intermedia phenotype in association with β°‐Thalassemia
Authors: J. Bardakdjian‐Michau, J. Delanoe‐Garin, C. Lacombe, Y. Blouquit, J. Riou, F. Galacteros, S. Fucharoen, P. Winichagoon, P. Wasi, J. Kister
Journal: American Journal of Hematology (1990)

Abstract While investigating the mechanism of a β‐thalassemia intermedia phenotype in a 34 year old Thai male, a new Hb variant β 126 Val → Gly named Hb Dhonburi was discovered. Genetic and structural studies revealed the existence of a β°‐thalassemia genotype in association with the β variant. The new variant is unstable but exhibits normal oxygen binding properties. Hb Dhonburi was also discovered in the mother of the propositus in association with Hb E.
THE ESSENTIAL PARTICIPATION OF AN ENZYME IN THE INHIBITION OF GROWTH OF TUBERCLE BACILLI BY SPERMINE
Authors: James G. Hirsch
Journal: The Journal of Experimental Medicine (1953)

Spermine inhibits the multiplication of tubercle bacilli in vitro only if another tissue substance is present in the culture medium. This activating substance occurs as a chemical contaminant of the albumin in commercial bovine plasma fraction V ordinarily added to culture media; it is also found in whole bovine and sheep serum and in aqueous extracts of the guinea pig kidney. No detectable spermine activator is contained in whole human, guinea pig, or rabbit serum. The serum constituent which renders spermine inhibitory for the growth of acid-fast bacteria has the properties of a protein of the alpha globulin classification. This protein is an enzyme which acts on spermine. Presumably, some product of the enzymatic reaction exerts a toxic effect on mammalian tubercle bacilli.
Class I molecules retained in the endoplasmic reticulum bind antigenic peptides.
Authors: C K Lapham, I Bacík, J W Yewdell, K P Kane, J R Bennink
Journal: The Journal of Experimental Medicine (1993)

We isolated major histocompatibility complex (MHC)-specific viral peptides from cells infected with influenza virus in the continuous presence of the drug brefeldin A, which blocks exocytosis of newly synthesized MHC class I molecules. MHC-specific peptides were also isolated from cells expressing mouse Kd class I MHC molecules whose cytoplasmic domain was substituted by that of the adenovirus E3/19K glycoprotein. This molecule was retained in an intracellular pre-Golgi complex compartment as demonstrated by immunocytochemical and biochemical means. Since we show that intracellular association of antigenic peptides with such retained class I molecules is necessary for their isolation from cellular extracts, this provides direct evidence that naturally processed peptides associate with class I MHC molecules in an early intracellular exocytic compartment.
Long-lasting memory T cell responses following self-limited acute hepatitis B.
Authors: A Penna, M Artini, A Cavalli, M Levrero, A Bertoletti, M Pilli, F V Chisari, B Rehermann, G Del Prete, F Fiaccadori, C Ferrari
Journal: Journal of Clinical Investigation (1996)

The molecular and cellular basis of long-term T cell memory against viral antigens is still largely undefined. To characterize anti-viral protection by memory T cells against non-cytopathic viruses able to cause acute self-limited and chronic infections, such as the hepatitis B virus (HBV), we studied HLA class II restricted responses against HBV structural antigens in 17 patients with acute hepatitis B, during the acute stage of infection and 2.2 to 13 yr after clinical resolution of disease. Results indicate that: (a) significant T cell proliferative responses to HBV nucleocapsid antigens were detectable in all patients during the acute phase of infection and in 14/17 also 2-13 yr after clinical resolution of disease; b) long-lasting T cell responses were sustained by CD45RO+T cells, predominantly expressing the phenotype of recently activated cells; c) limiting dilution analysis showed that in some patients the frequency of HBV-specific T cells was comparable to that observed in the acute stage of infection and, usually, higher than in patients with chronic HBV infection; d) the same amino acid sequences were recognized by T cells in the acute and recovery phases of infection; and e) HBV-DNA was detectable by nested-PCR in approximately half of the subjects. to conclusion, our results show that vigorous anti-viral T cell responses are detectable in vitro several years after clinical recovery from acute hepatitis B. Detection of minute amounts of virus in some recovered subjects suggests that long-term maintenance of an active anti-viral T cell response could be important not only for protection against reinfection but also for keeping the persisting virus under tight control.
Soundings: Back to basics
Authors: C Douglas
Journal: BMJ (1994)

On an un-familiar route through the north of the former Lanarkshire, the train stopped just long enough. The village - a few rows of turn of the century miners' cottages - was still there. To my greater surprise so was the school: a little clutch of the kind of wartime single storey wooden buildings that even the NHS has by now largely dispensed with.

Let us call the village Pitmirk and the school Pitmirk Primary School. I encountered both 30 years ago when Pitmirk, along with five other Lanarkshire primary schools, sent a class of 11 year olds for a month in the country. Proper country. Genteel Perthshire in September. …
Contempo 1997: Dermatology-Reply
Authors: M. B. Alora
Journal: JAMA (1997)

<h3>In Reply.</h3> —The results of initial studies cited by Drs Marks and Saltzman discussing the effectiveness of topical penciclovir illustrate the conundrum confronting clinicians in differentiating results of clinical significance in patient care as opposed to those found to be statistically significant. If patients were to have topical penciclovir in hand at the time of a herpes labialis recurrence, begin application within 1 hour of onset, and continue application every 2 hours while awake for the next 4 days, the mean duration of lesions and pain might be reduced by approximately half a day. Is this decrement of disease worth the expense and the need for very frequent application? In our view, a few hours of potential improvement is not a "significant" addition to our armamentarium of antiviral therapy. Of the 2 new oral antiviral agents, only famciclovir has been shown to be effective in reducing the duration of postherpetic neuralgia in
Occupational allergy caused by Dianthus caryophillus, Gypsophila paniculata, and Lilium longiflorum
Authors: C. Vidal, F. Polo
Journal: Allergy (1998)

Background Occupational allergy to ornamental flowers is seldom reported. Methods We report a case of a 35‐year‐old male flower supplier who developed IgE‐mediated allergic rhinoconjunctivitis with nasal polyps, and contact urticaria and dermatitis after handling Gypsophila paniculata, Dianthus caryophiUtis. and Lilium longiflortim . Results Studies revealed the presence of positive immediate skin prick tests. Rubbing tests were positive to G. paniculata and D. caryophillus . Serum specific IgE was detected against G. paniculata and L. longiflorum . In IgE immunoblot, two IgE‐binding bands (15 and 17 kDa) were obtained against D. caryophillus, and two different bands (19 and 22 kDa) were visible against L. longiflorttm . Conclusions TTiese findings suggest an IgE‐mediated reaction as the mechanism responsible for the respiratory and cutaneous symptoms of the patient. No similar eases of allergy to D. caryophillus and L. longiflorum have been previously reported.
Detection of occult low-grade B-cell non-hodgkin's lymphoma in patients with chronic hepatitis C infection and mixed cryoglobulinemia
Authors: Imran Rasul, Frances A. Shepherd, Suzanne Kamel-Reid, Mell Krajden, Dominic Pantalony, Jenny E. Heathcote
Journal: Hepatology (1999)

Hepatitis C virus (HCV) is both hepatotropic and lymphotropic and has been shown to be associated with the benign lymphoproliferative disorder, mixed cryoglobulinemia (MC). Preliminary studies suggest that there may be an association between chronic hepatitis C, MC, and non-Hodgkin's lymphoma (NHL). The aim of this study was to determine whether patients with chronic HCV and MC have occult bone marrow NHL. Sixteen patients with chronic HCV and clinically active MC underwent bone marrow biopsy and aspiration. Flow cytometry was performed looking for abnormal B-cell lineage. Molecular genetic studies were performed to identify B-cell monoclonality. Nine of 16 patients (56%) had abnormal marrow morphology, 7 (44%) were interpreted as suspicious for lymphoma, and 2 (13%) as consistent with lymphoma. Flow cytometry on 13 patients identified 5 (39%) with increased B-cell populations. Molecular analysis on 13 patients identified 3 (23%) with monoclonal proliferation of the B-cell lineage. All 13 patients tested for Epstein-Barr virus were negative by polymerase chain reaction (PCR). Four of 16 patients (25%) had marrow morphology and evidence of a monoclonal B-cell population by flow cytometry and/or molecular studies, consistent with B-cell NHL. These findings confirm the presence of lymphoproliferative disorders in patients with chronic HCV and MC. Some of these disorders meet the morphological and molecular criteria for the diagnosis of malignant lymphoma.
Plasminogen binding sites in normal human skin
Authors: S. M. BURGE, J. M. MARSHALL, S.A. CEDERHOLM-WILLIAMS
Journal: British Journal of Dermatology (1992)

Journal Article Plasminogen binding sites in normal human skin Get access S. M. BURGE, S. M. BURGE Department of Dermatology, The Slade Hospital, Oxford, U.K. Dr S.M.Burge, Department of Dermatology, The Slade Hospital, Oxford OX3 7JH, U.K. Search for other works by this author on: Oxford Academic Google Scholar J. M. MARSHALL, J. M. MARSHALL Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, U.K. Search for other works by this author on: Oxford Academic Google Scholar S.A. CEDERHOLM‐WILLIAMS S.A. CEDERHOLM‐WILLIAMS Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 126, Issue 1, 1 January 1992, Pages 35–41, https://doi.org/10.1111/j.1365-2133.1992.tb08400.x Published: 01 January 1992
Erythropoietin inhibits respiratory epithelial cell apoptosis in a model of acute lung injury
Authors: R. MacRedmond, G. K. Singhera, D. R. Dorscheid
Journal: European Respiratory Journal (2009)

Fas-mediated apoptosis of the alveolar epithelium is important in the pathogenesis of acute respiratory distress syndrome. Erythropoietin (EPO) has cytoprotective properties in other organ systems, and is relatively deficient in critical illness. This study investigates a potential role for EPO in reducing apoptosis in a model of acute lung injury. Apoptosis was induced in human alveolar epithelial (A549) cells or normal human bronchial epithelial (NHBE) cells by Fas activation with CH-11 Fas-crosslinking antibody or by co-culture with polymorphonuclear neutrophils in a transwell system. The effect of recombinant human (rh)EPO on apoptosis was measured by poly(ADP-ribose) polymerase cleavage and cell death detection assay. The specific EPO–EPO receptor (EPOR)-mediated effect was determined using an EPO-blocking antibody or EPOR small interfering RNA. Expression of EPOR was demonstrated in A549, NHBE and normal human alveolar epithelium. Fas- and neutrophil-mediated apoptosis of A549 and NHBE cells was inhibited by rhEPO by a specific EPO–EPOR-mediated mechanism. This anti-apoptotic effect was associated with induction of a pro-apoptotic Bcl-xL/Bax ratio. EPO has cytoprotective properties in respiratory epithelium in an in vitro model, which may indicate a potential therapeutic role in acute lung injury.