Persistence of Trophozoites After Successful Treatment of Pneumocystis carinii Pneumonia
Authors: WAFAA EL-SADR
Journal: Annals of Internal Medicine (1986)

Brief Reports1 December 1986Persistence of Trophozoites After Successful Treatment of Pneumocystis carinii PneumoniaWAFAA EL-SADR, M.D., GURDIP SIDHU, M.D.WAFAA EL-SADR, M.D.Search for more papers by this author, GURDIP SIDHU, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-6-889 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPneumocystis carinii pneumonia has grown in importance due to the special predilection of patients with the acquired immunodeficiency syndrome (AIDS) to develop this infection. More than 60% of such patients develop P. carinii pneumonia and about 20% have a recurrence (1). We report a case of a patient with AIDS and P. carinii pneumonia in whom a repeat biopsy after clinical response to therapy with trimethoprim-sulfamethoxazole failed to show P. carinii cysts while electron microscopy showed many trophozoites of P. carinii.A 37-year-old intravenous drug abuser was hospitalized with a 2-month history of fever and cough. The patient had a...References1. . Update: acquired immunodeficiency syndrome—United States. MMWR. 1985;34:245-8. MedlineGoogle Scholar2. KIM H and HUGHES W. Comparison of methods for identification of Pneumocystis carinii in pulmonary aspirates. Am J Clin Pathol. 1973;60:462-6. CrossrefMedlineGoogle Scholar3. CUSHION M and WALZER P. Growth and serial passage of Pneumocystis carinii in A549 cell line. Infect Immun. 1984;44:245-51. CrossrefMedlineGoogle Scholar4. KOVACS J, HIEMENZ J, and MACHER A. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med. 1984;100:663-71. LinkGoogle Scholar5. SHELHAMER J, OGNIBENE A, and MACHER A. Persistence of Pneumocystis carinii in lung tissue of acquired immunodeficiency syndrome patients treated for pneumocystis pneumonia. Am Rev Respir Dis. 1984;130:1161-5. MedlineGoogle Scholar6. FRENKEL J, GOOD J, and SHULTZ J. Latent pneumocystis infection of rats, relapse, and chemotherapy. Lab Invest. 1966;15:1559-77. MedlineGoogle Scholar7. WALZER P and RUTLEDGE M. Comparison of rat, mouse, and human Pneumocystis carinii by immunofluorescence. J Infect Dis. 1980;142:449. CrossrefMedlineGoogle Scholar8. CUSHION M, STANFORTH D, LINKE M, and WALZER P. Method of testing the susceptibility of Pneumocystis carinii to antimicrobial agents in vitro. Antimicrob Agents Chemother. 1985;28:796-801. CrossrefMedlineGoogle Scholar9. MASUR H. Interaction between Pneumocystis carinii and phagocytic cell. In: YOUNG LS, ed. Pneumocystis carinii Pneumonia: Pathogenesis, Diagnosis, Treatment. New York: Marcel Dekker Inc.; 1984:77-95. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WAFAA EL-SADR, M.D.; GURDIP SIDHU, M.D.Affiliations: New York University Medical Center the New York Veterans Administration Medical Center New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPerformance of real-time PCR and immunofluorescence assay for diagnosis of Pneumocystis pneumonia in real-world clinical practicePneumocystis jiroveci PneumoniaPolymerase chain reaction detection of Pneumocystis jiroveci: evaluation of 9 assaysPNEUMOCYSTIS CARINIIUltrastructural Pathology of Human Immunodeficiency Virus InfectionPneumocystis Carinii Pneumonia ProphylaxisPneumocystis cariniiManagement of Pneumocystis carinii Pneumonia in Patients with AIDS and Other Conditions: Experience in a Philadelphia University Teaching HospitalDapsone treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome 1 December 1986Volume 105, Issue 6Page: 889-890KeywordsAddictsAIDSBiopsyElectron microscopyFeversInfectious diseasesPneumocystis carinii pneumoniaPneumonia ePublished: 1 December 2008 Issue Published: 1 December 1986 PDF downloadLoading ...