Methimazole-Induced Agranulocytosis and Granulocyte-Colony Stimulating Factor
Authors: B. Heinrich
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 October 1989Methimazole-Induced Agranulocytosis and Granulocyte-Colony Stimulating FactorB. Heinrich, M. Gross, MD, F.D. Goebel, MDB. HeinrichSearch for more papers by this author, M. Gross, MDSearch for more papers by this author, F.D. Goebel, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-7-621_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Agranulocytosis represents a life-threatening complication of methimazole therapy, occurring in 0.1% to 1% of patients (1). Course and duration of agranulocytosis may be highly variable (2). Recently, human hematopoietic growth factors, especially granulocyte-macrophage colony stimulating factor (GM-CSF), have proved useful in the treatment of idiopathic aplastic anemia, idiopathic neutropenia, and chemotherapy-associated agranulocytosis (3, 4). That GM-CSF might also be useful in drug-induced allergic-toxic agranulocytosis is suggested in a case report by Delannoy and Gehenot (5). To support this hypothesis we report successful GM-CSF treatment of a 36-year-old woman who had methimazole-induced agranulocytosis.Four weeks before admission, the...References1. . Risk of agranulocytosis and aplastic anemia in relation to use of anti-thyroid drugs. Br Med J. 1988;297:262-5. CrossrefMedlineGoogle Scholar2. WeitzmanStosselDesmond STM. Drug-induced immunological neutropenia. Lancet. 1978;1:1068-72. CrossrefMedlineGoogle Scholar3. Metcalf D. Hematopoetic growth factors 2: clinical applications. Lancet. 1989;1:885-7. CrossrefMedlineGoogle Scholar4. JakubowskiSouzaKelley ALF. Effects of human granulocyte colony-stimulating factor in a patient with idiopathic neutropenia. N Engl J Med. 1989;320:38-42. CrossrefMedlineGoogle Scholar5. DelannoyGehenot AM. Colony-stimulating factor and drug-induced agranulocytosis. Ann Intern Med. 1989;110:942-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Med. Poliklinik d. 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