tbuckley/cabot-search huggingface dataset:
Estimation of Respiratory Center Drive With Carbon-Dioxide-Helium.
Authors: Joseph L. Grant
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Estimation of Respiratory Center Drive With Carbon-Dioxide-Helium.Joseph L. Grant, M.D., F.A.C.P., Eugene Lussier, M.D., Mark MahnkeJoseph L. Grant, M.D., F.A.C.P.Search for more papers by this author, Eugene Lussier, M.D.Search for more papers by this author, Mark MahnkeSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-810_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRespiratory-center drive may be lessened in patients with chronic obstructive pulmonary disease. This study reports on the assessment of respiratory-center drive by having patients breathe mixtures of carbon dioxide in increasing concentration with and without helium. With turbulent air flow, helium offers a decrease in airway resistance, and if ventilation rises normally when helium replaces nitrogen in the inspired gas, one can conclude that respiratory-center sensitivity to carbon dioxide is intact. The results in 27 normal subjects, 14 patients with chronic obstructive disease, and 1 patient with idiopathic hypoventilation are presented in support of this concept. They breathed 0, 3,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Joseph L. Grant, M.D., F.A.C.P.; Eugene Lussier, M.D.; Mark MahnkeAffiliations: White River Junction, Vt.; and Hanover, N.H. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 810-810KeywordsAir flowAttentionCarbon dioxideChronic obstructive pulmonary disease ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
Antiglycolipid autoantibody detected in the sera from systemic lupus erythematosus patients.
Authors: T Hirano, H Hashimoto, Y Shiokawa, M Iwamori, Y Nagai, M Kasai, Y Ochiai, K Okumura
Journal: Journal of Clinical Investigation (1980)

A high incidence of autoantibody against the neutral glycolipid "asialo GM1" was observed in sera from patients with systemic lupus erythematosus (SLE) with neurological disorders, using an immunoflocculation test. The sera from 14 out of 17 cases of SLE with neurological disorders showed antibody activity against asialo GM1 but not against the following glycolipids: asialo GM2 GM1, and galactocerebroside. In another 87 cases of SLE without any history of seizures, as well as 61 cases of other autoimmune diseases (rheumatoid arthritis, progressive systemic sclerosis, mixed connective tissue disease, etc.) and 20 cases of various neurological diseases (epilepsy, multiple sclerosis, etc.), no antibody could be detected. In general, the antibody titer was high several months, even years, before and/or after the seizure, though the titer was low at the time that patients showed definite neurological symptoms. Immunochemical characterization with Sephadex G-200 chromatogrphy and protein A-Sepharose CL-4B affinity column indicated that the antiasialo GM1 was probably an autoantibody belonging to the immunoglobulin G class. The above results suggest that this newly found autoantibody plays a role in the pathogenesis of neurological disorders accompanying SLE.
Meta-Analysis Comparing the Effectiveness and Adverse Outcomes of Antifibrinolytic Agents in Cardiac Surgery
Authors: Jeremiah R. Brown, Nancy J.O. Birkmeyer, Gerald T. O’Connor
Journal: Circulation (2007)

Background— Since the 1980s, antifibrinolytic therapies have assisted surgical teams in reducing the amount of blood loss. To date, however, serious questions remain regarding the safety and effectiveness of these agents. Methods and Results— We conducted a meta-analysis to compare aprotinin, ε-aminocaproic acid, and tranexamic acid with placebo and head to head on 8 clinical outcomes from 138 trials. Published randomized controlled trial data were collected from OVID/PubMed. Outcomes included total blood loss, transfusion of packed red blood cells, reexploration, mortality, stroke, myocardial infarction, dialysis-dependent renal failure, and renal dysfunction (0.5-mg/dL increase in creatinine from baseline). All agents were effective in significantly reducing blood loss by 226 to 348 mL and the proportion of patients transfused with packed red blood cells over placebo. Only high-dose aprotinin reduced the rate of reexploration (relative risk, 0.49; 95% CI, 0.33 to 0.73). There were no significant risks or benefits for any agent for mortality, stroke, myocardial infarction, or renal failure. However, high-dose aprotinin significantly increased the risk of renal dysfunction (relative risk, 1.47; 95% CI, 1.12 to 1.94), 12.9% versus 8.4%. Compared head to head, high-dose aprotinin demonstrated significant reduction in total blood loss over ε-aminocaproic acid (−184 mL; 95% CI, −256 to −112) and tranexamic acid (−195 mL; 95% CI, −286 to −105). There were no significant differences among any agent when compared head to head on other outcomes. Conclusions— All antifibrinolytic agents were effective in reducing blood loss and transfusion. There were no significant risks or benefits for mortality, stroke, myocardial infarction, or renal failure. However, high-dose aprotinin was associated with a statistically significant increased risk of renal dysfunction.
Health Decision Aids To Facilitate Shared Decision Making in Office Practice
Authors: Michael J. Barry
Journal: Annals of Internal Medicine (2002)

For medical decisions with more than one reasonable option, patient participation in decision making is often necessary to optimally match management decisions with patient preferences. Health decision aids are designed to facilitate shared decision making by helping patients and their physicians choose among reasonable clinical options. Although these aids vary in content, common denominators are the presentation of more than one reasonable strategy for a clinical management question and a description of the possible outcomes of the various options. Although the number of published randomized trials assessing the impact of health decision aids on the quality of medical decisions is limited (but growing), various types of decision aids do generally appear to inform patients about their treatment options better than "usual care" can. Little evidence is available to determine whether one type of decision aid is optimal, but more complicated programs seem to have larger effects. The cost-effectiveness of decision aids has not been studied, although it is enticing to think that the pattern of more conservative decisions by users of some decision aids could reduce medical care costs in a manner that is dictated by patient preferences.
Worksite anti-alcoholism saves jobs, money
Authors: Milan Korcok
Journal: JAMA (1983)

In little more than a decade, alcoholism has been transformed in people's minds from a moral failing, not to be discussed in polite society, to a Middle American disease. Over the same period, its therapy has improved enormously, and alcoholics have become far more candid about their problem. Consequently, they have become more successful in linking up with treatment methods and facilities that yield a better-than-even chance of return to productive life.  Just how far this candor has gone was apparent at a recent conference on alcoholism in the workplace that featured a former President of the United States. Gerald Ford not only pledged to use his influence in American corporate boardrooms to advocate better responses to a disease that saps industry of so much strength, but also discussed the impact of alcoholism on his own family. (Former First Lady Betty Ford's battle with the illness was disclosed in 1978
Effect of the Lipidosterolic Extract of Serenoa repens (Permixon&lt;sup&gt;&amp;reg;&lt;/sup&gt;) and Its Major Components on Basic Fibroblast Growth Factor-Induced Proliferation of Cultures of Human Prostate Biopsies
Authors: Monique Paubert-Braquet, Henri Cousse, Jean-Pierre Raynaud, Jean Michel Mencia-Huerta, Pierre Braquet
Journal: European Urology (1998)
Pregnancy does not mean that patients with tuberculosis must stop treatment
Authors: G. Bothamley, W. Elston
Journal: BMJ (1999)

EDITOR—We were disappointed that Rubin's review of drugs that could safely be taken in pregnancy did not mention drugs for tuberculosis.1 Adherence to successful treatment of tuberculosis is essential. In 1998 three patients with tuberculosis (of 114 such patients treated at Homerton Hospital) became pregnant; all three were advised by their general practitioner or midwife to stop their treatment, and two accepted a termination. In addition, two of 71 female patients receiving preventive treatment with isoniazid were advised …
Electronic Health Records, After-Hours Care Lag in US Primary Care Practices
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumococcal conjugate vaccine provides early protective antibody responses in children after related and unrelated allogeneic hematopoietic stem cell transplantation
Authors: Roland Meisel, Lisa Kuypers, Uta Dirksen, Ralf Schubert, Bernd Gruhn, Gabriele Strauss, Karin Beutel, Andreas H. Groll, Ulrich Duffner, Renate Blütters-Sawatzki, Wolfgang Holter, Tobias Feuchtinger, Hans-Peter Grüttner, Horst Schroten, Stefan Zielen, Christian Ohmann, Hans-Jürgen Laws, Dagmar Dilloo
Journal: Blood (2006)
THE HOLISTIC APPROACH IN PSYCHIATRY
Authors: ANDRAS ANGYAL
Journal: American Journal of Psychiatry (1948)

The holistic approach seeks to understand the person on the basis of his organization. An organization cannot be described in terms of one-to-one relations but in terms of systems. Systems are types of order, arrangements of parts according to a unifying principle, the system principle. An item functions as part of a whole through the occupancy of a position; it has a positional value within the structure of the whole. Personality organization is a hierarchy of systems. Any constituent of personality may function as a part of several subsystems at the same time. Holistic determinism allows for more than one single effect; it determines only the range within which the effect will fall. In the life of the person interactions do take place not only in the direction, past-present-future, but also in the opposite direction. The law of continuous spread of system action states that only neighboring systems can effect each other in a hierarchy of systems. The holistic approach as outlined here does not contain assumptions about specific psychiatric phenomena but describes a way of thinking which I believe is fruitful for the clarification of psychiatric problems.
Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axis
Authors: Jason Boyang Wu, Chen Shao, Xiangyan Li, Changhong Shi, Qinlong Li, Peizhen Hu, Yi-Ting Chen, Xiaoliang Dou, Divya Sahu, Wei Li, Hiroshi Harada, Yi Zhang, Ruoxiang Wang, Haiyen E. Zhau, Leland W.K. Chung
Journal: Biomaterials (2014)
Influenza in Nursing Homes
Authors: THEODORE G. GANIATS
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 April 1988Influenza in Nursing HomesTHEODORE G. GANIATS, M.D., ANTHONY F. WONG, M.D.THEODORE G. GANIATS, M.D.Search for more papers by this author, ANTHONY F. WONG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-644_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their article on type A influenza prevention and control in nursing homes, Patriarca and colleagues (1) express cost-effectiveness as the ratio of the net health care costs to net health effects. They should be commended for acknowledging that including the costs of continuing institutional care during years-of-life gained often biases a cost-effectiveness analysis, and disregarding these costs may be acceptable. However, they ignore a basic principle of cost-effectiveness research and later do a misleading calculation.Direct medical costs, defined by the authors as the costs of treatment and hospitalization for those acquiring influenza, should have been...References1. PATRIARCA P, ARDEN N, KOPLAN J, and GOODMAN R. Prevention and control of type A influenza infections in nursing homes. Ann Intern Med. 1987;107:732-40. LinkGoogle Scholar2. WEINSTEIN M and STASON W. Foundations of cost-effectiveness analysis for health and medical practices. N Engl J Med. 1977;296:716-21. CrossrefMedlineGoogle Scholar3. RUSSELL L. Evaluating Preventive Care. Washington, D.C: The Brookings Institution; 1987:71-3. Google Scholar4. ANDERSON J, BUSH J, CHIN M, and DOLENC D. Policy space areas and properties of benefit-cost/utility analysis. JAMA. 1986;255:794-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THEODORE G. GANIATS, M.D.; ANTHONY F. WONG, M.D.Affiliations: University of California San Diego; La Jolla, CA 92093 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1988Volume 108, Issue 4Page: 644-645KeywordsHealth careHospitalizationsNursing homes ePublished: 1 December 2008 Issue Published: 1 April 1988 PDF downloadLoading ...
Assessment of Diastolic Function with Mitral Annular Plane Systolic Excursion in Obese Adults
Authors: Hakan Taşolar, Türkan Mete, Mustafa Çetin, Burak Altun, Mehmet Ballı, Adil Bayramoğlu, Ömür Otlu, Hasan Pekdemir
Journal: Journal of the American College of Cardiology (2013)
CONSERVATISM IN SURGERY
Authors: A. D. WHITING
Journal: JAMA (1913)

<i>Vis medicatrix naturae!</i>The great underlying factor in all of the many advances in medicine and surgery that the world has witnessed during the past fifty years is the healing power of Nature. Without this wonderful power, many of the results of our attempts to relieve humanity of the numerous lesions to which the flesh is heir would be appalling; even with this aid many of them are distressing. If we could fathom the wonders of Nature as exemplified in her power to construct, maintain and reconstruct, to eliminate harmful products, to cure disease, our task of aiding the sick and afflicted would be greatly simplified. Nature, alone, until the most recent times, has effected a cure in most diseases; the physician and surgeon have but aided in conserving the strength of the individual until Nature's work has been accomplished. To-day, by taking advantage of the slight knowledge he has
CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation
Authors: Mark A. Daniels, Lesley Devine, Joseph D. Miller, Janice M. Moser, Aron E. Lukacher, John D. Altman, Paula Kavathas, Kristin A. Hogquist, Stephen C. Jameson
Journal: Immunity (2001)
Aerosol Steroids for Asthma
Authors: Frank Chmelik
Journal: JAMA (1975)

To the Editor.—  The discussion by Dr. M. Henry Williams, Jr., on the use of aerosol steroids in the treatment of asthma (231:406, 1975) was most interesting.  I agree that every effort should be made to make these agents available in the United States; however, I would add, not until they have been demonstrated to not have significant side effects. Specifically, the wellknown propensity of triamcinolone acetonide to cause atrophy of the skin should be looked for in the tracheal bronchial tree as well as any other part of the respiratory tract coming in contact with the spray. Ear, nose, and throat evaluation as well as voice analysis of patients receiving these sprays on a long-term basis is necessary.  The term allergic alveolitis is most confusing. To reach the alveoli, particle size of about one micron is necessary. It is quite important that we record the size of the particles
P1224 GSK2878175, A POTENT NON-NUCLEOSIDE INHIBITOR OF HCV NS5B WITH PAN-GENOTYPIC ACTIVITY
Authors: R. Hamatake, C. Voitenleitner, R. Crosby, J. Walker, A. Wang, L. Wright, B. Shotwell, M. Leivers, A. Peat, Z. Hong
Journal: Journal of Hepatology (2014)
Vitiligo: an underestimated problem in general practice?
Authors: G. Agarwal
Journal: BMJ (1997)

My first encounter with vitiligo occurred as a child, at a social function, when a relative referred to a fellow guest with vitiligo as “that spotted man.” I never gave the issue much thought until as a medical student I met a young man with everything in life going for him—except that he had vitiligo. The condition was rapidly encroaching over his body, but had not reached his face. He felt that he was living with the “sword of Damocles” hanging over his head. I became more involved with patients with vitiligo during the course of my clinical career and as a general practitioner, when I saw patients with vitiligo and diagnosed them for the first time.

I am sure that many doctors know the term vitiligo but have never really considered any more about it. It comes from the Latin “vitellus” which means “spotted calf” and this describes the condition exactly. It is a common skin …
Book Review Immunologic Disorders in Infants and Children Fifth edition. Edited by E. Richard Stiehm, Hans D. Ochs, and Jerry A. Winkelstein. 1512 pp., illustrated. Philadelphia, Saunders, 2004. $295. 0-7216-8964-7
Authors: Ramsay L. Fuleihan
Journal: New England Journal of Medicine (2005)
Dumping Syndrome
Authors: Banice M. Webber, Merrill A. Bender, George E. Moore
Journal: New England Journal of Medicine (1957)

TN recent years subtotal gastrectomy has, for the majority of surgeons, come to be accepted as the surgical treatment of choice for peptic ulceration of the stomach and duodenum. In addition, with the improvement in over-all surgical mortality more patients are surviving after attacks on malignant lesions of the upper gastrointestinal tract, the procedures for such lesions usually being subtotal or total gastrectomy. Thus, more attention has come to be focused on the postgastrectomy patient, and when evaluating such patients, the surgeon often has cause to be dissatisfied with the so-called "side effects" of his treatment. Among the disturbing symptom . . .
The spleen preserved.
Authors: D Roy
Journal: BMJ (1984)

way an adequate fibre intake is achieved in a variety of forms without difficulty.Fifteen years on, the fibre hypothesis has survived.In the short term, colonic function may be modified and symptoms, particularly constipation, relieved.Gastrointestinal absorption may be controlled and some metabolic disorders stabilised.Yet the long term benefits from prophylactic use of high fibre diets are not proved and may never be so: too many extrinsic factors play a part both in the diet and in the environment generally.Epidemiological and circumstantial pointers suggest that there may be some advantages in taking a mixed, high fibre diet, but its prophylactic use still remains a matter of philosophy.
Depersonalization, Dysphoria, and Thought Disturbance
Authors: G. J. TUCKER, M. HARROW, D. QUINLAN
Journal: American Journal of Psychiatry (1973)

In a previous study the authors demonstrated a significant association between depersonalization and anxiety; in the present one they replicate this finding with an additional 155 patients and also delineate the close association of depersonalization with dysphoric affect and specific types of pathological thinking. From these data it appears that the patient who experiences depersonalization is a person with chronic anxiety, persistent depressive affect, and some degree of psychopathological thinking. It is hypothesized that depersonalization may then be the perceived feeling or experiential state of the person who has this constellation of symptoms.
Assessment of nutritional quality of wheat malt extract and preparation of non-conventional malted health beverages
Authors: Kanika Anand, Parul Sharma
Journal: British Journal of Sports Medicine (2010)

Consumer awareness for the deleterious impact of malnutrition on health has grown in the last years. Thus leading to the increase in the demand for natural food and beverage products by health conscious consumers. The present study attempts to introduce a novel concept for the production of non-conventional health beverages based on malted wheat extract (variety used HD2733). In view of their health credentials these malted health beverages can be used as healthier alternative to conventional soft drinks and alcoholic beverages. The study involves the determination of physical characteristics of unmalted and nutrient analysis of both malted and unmalted wheat kernels of chosen varieties. Sensory acceptability of prepared malted health beverages that is, malted coffee and malted ice-cream milk shake was also evaluated at 5%, 15% and 20% incorporations. Physical characteristics of kernel that is, 1000 kernel weight, hectolitre weight, grain length and width were 42.4 g, 80.9 kg, 6.5 mm and 3.30 mm, respectively. Malting resulted in slight increase in certain nutrients like protein content, mineral ash content, calcium and ascorbic levels, although a decrease in fat content, iron content and phytic acid levels was observed post malting. Sensory acceptability based on the overall acceptability showed malted health beverages prepared from 15% malt extract were most acceptable. Thus some modifications in the well known processes in the brewing industry would pave the way to design and produce innovative malt based health drinks.
Constraints on the construction of cognition
Authors: Mark H. Johnson, Liz Bates, Jeff Elman, Annette Karmiloff-Smith, Kim Plunkett
Journal: Behavioral and Brain Sciences (1997)

We add to the constructivist approach of Quartz &amp; Sejnowski (Q&amp;S) by outlining a specific classification of sources of constraint on the emergence of representations from Elman et al. (1996). We suggest that it is important to consider behavioral constructivism in addition to neural constructivism.
Serum Folate and Risk of Fatal Coronary Heart Disease
Authors: Howard I. Morrison
Journal: JAMA (1996)

To assess the relationship between serum folate level and the risk of fatal coronary heart disease (CHD) among men and women.Retrospective cohort study with serum folate levels measured from September 1970 to December 1972, with follow-up through 1985.Participants in the Nutrition Canada Survey.A total of 5056 Canadian men and women aged 35 to 79 years with no history of self-reported CHD.Fifteen-year CHD mortality.A total of 165 CHD deaths were observed. We found a statistically significant association between serum folate level and risk of fatal CHD, with rate ratios for individuals in the lowest serum folate level category (<6.8 nmol/L [3 ng/mL]) compared with the highest category (>13.6 nmol/L [6 ng/mL]) of 1.69 (95% confidence interval, 1.10-2.61).These data indicate that low serum folate levels are associated with an increased risk of fatal CHD.