tbuckley/cabot-search huggingface dataset:
What causes worsening of eczema? A systematic review
Authors: S.M. Langan, H.C. Williams
Journal: British Journal of Dermatology (2006)

Background Flares of eczema are attributed to many factors, often with minimal scientific evidence. Objectives Systematically to search, summarize and critically appraise the scientific evidence to support the roles of individual 'flare factors' in eczema. Methods We searched Medline from 1966 until 20 April 2005 to identify relevant articles for inclusion in this review. No language restrictions were imposed. All study designs were included and were ranked according to the strength of evidence. Experimental and provocation studies were restricted to those using a double‐blind design. We included randomized controlled trials if they were provocation studies. Meta‐analysis was not possible due to differences in study populations and methodology. The studies are therefore described qualitatively. Results The roles of foodstuffs (13 studies), house dust mite (three), other aeroallergens (two), seasonality (two), bacterial infections (one), textiles (three), detergents (one), sunlight (one) and stress (two) were assessed in different study populations, using a variety of study designs. All studies were performed on selected groups and only four were longitudinal in design. Collectively, these studies provide some evidence that certain foods, house dust mite, stress and seasonal factors are relevant causes of disease worsening in certain subgroups with eczema. No good evidence could be found to support the role of detergents, textiles and irritants in causing worsening of eczema. Conclusions Despite anecdotal lists in textbooks and review articles, very little good evidence exists for 'flare factors' in eczema. The focus of all of the included studies was on disease worsening rather than clinically relevant flares. Studies of longitudinal design are required to clarify the roles of these and other putative flare factors in eczema.
Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial
Authors: Harry Bartelink, Philippe Maingon, Philip Poortmans, Caroline Weltens, Alain Fourquet, Jos Jager, Dominic Schinagl, Bing Oei, Carla Rodenhuis, Jean-Claude Horiot, Henk Struikmans, Erik Van Limbergen, Youlia Kirova, Paula Elkhuizen, Rudolf Bongartz, Raymond Miralbell, David Morgan, Jean-Bernard Dubois, Vincent Remouchamps, René-Olivier Mirimanoff, Sandra Collette, Laurence Collette
Journal: The Lancet Oncology (2014)
Shock Wave for Heel Pain
Authors: Jane E. Henney
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictive Factors of Restenosis After Coronary Stent Placement
Authors: Adnan Kastrati, Albert Schömig, Shpend Elezi, Helmut Schühlen, Josef Dirschinger, Martin Hadamitzky, Anne Wehinger, Jörg Hausleiter, Hanna Walter, Franz-Josef Neumann
Journal: Journal of the American College of Cardiology (1997)
Historical Background of the Use of Radioactive Iodine in Medicine
Authors: J. H. Means
Journal: New England Journal of Medicine (1955)

THE expansion of research on the thyroid gland that the past eighteen years have witnessed resulted from the meeting of two quite distinct lines of inquiry and discovery. The more ancient of these is that which through the centuries has identified the element iodine ever more closely with the thyroid gland, and the other, man's discovery that certain elements give off, or can be caused to give off, certain types of radiation. When these lines met, a new era opened in the progress of the understanding of the physiology and biochemistry of the thyroid gland and its diseases.The thyroid-iodine . . .
Human Amygdala Activation during Conditioned Fear Acquisition and Extinction: a Mixed-Trial fMRI Study
Authors: Kevin S LaBar, J.Christopher Gatenby, John C Gore, Joseph E LeDoux, Elizabeth A Phelps
Journal: Neuron (1998)

Echoplanar functional magnetic resonance imaging (fMRI) was used in normal human subjects to investigate the role of the amygdala in conditioned fear acquisition and extinction. A simple discrimination procedure was employed in which activation to a visual cue predicting shock (CS+) was compared with activation to another cue presented alone (CS−). CS+ and CS− trial types were intermixed in a pseudorandom order. Functional images were acquired with an asymmetric spin echo pulse sequence from three coronal slices centered on the amygdala. Activation of the amygdala/periamygdaloid cortex was observed during conditioned fear acquisition and extinction. The extent of activation during acquisition was significantly correlated with autonomic indices of conditioning in individual subjects. Consistent with a recent electrophysiological recording study in the rat (51Quirk G.J Armony J.L LeDoux J.E Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala.Neuron. 1997; 19: 613-624Abstract Full Text Full Text PDF PubMed Scopus (441) Google Scholar), the profile of the amygdala response was temporally graded, although this dynamic was only statistically reliable during extinction. These results provide further evidence for the conservation of amygdala function across species and implicate an amygdalar contribution to both acquisition and extinction processes during associative emotional learning tasks.
Prostaglandin e<sub>2</sub>‐hemoglobin AA and SS erythrocyte interaction (prostaglandin‐erythrocyte interaction)
Authors: Joseph T. Sobota, Carolyn A. Gruber, Terry J. Gilbertson, Jerome Wilson
Journal: American Journal of Hematology (1977)

Abstract Prostaglandin E 2 (PGE 2 ), at concentrations ≥ 5 × 10 4 ng/ml, induced discocyte → echinocyte transformation of saline‐suspended hemoglobin (Hb) AA and SS erythrocytes. This erythrocyte transformation is concentration‐dependent and is reversible at room temperature after 90–120 min. The Hb SS erythrocytes treated with PGE 2 did not exhibit accelerated sickling or increased formation of sickled echinocvtes. Erythrocytes suspended in autologous plasma treated with PGE 2 , 2 × 10 6 ng/ml, did not exhibit echinocytic transformation probably because of drug binding to the plasma proteins. Other in vitro studies showed that PGE 2 of concentrations of 10–500 ng/ml had no adverse effects on intact, plasma‐suspended Hb SS erythrocytes. These Hb SS erythrocytes were examined for changes in morphology, potassium and calcium flux, and blood viscosity under oxygenated and hypoxic conditions.
&lt;emph type="ital"&gt;Half-Tide, Annisquam River&lt;/emph&gt;
Authors: M. Therese Southgate
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The College of Medicine
Authors: J. Cassidy
Journal: BMJ (2011)

The College of Medicine, which launched in October last year ( BMJ 2010;341:c6126, doi:10.1136/bmj.c6126), aims to promote holistic medicine in the NHS. Its president is Graeme Catto, former president of the General Medical Council. Its vice president is Ian Kennedy, an expert in medical ethics whose review of children’s health services for the Department of Health for England was published in September ( BMJ 2010;341:c5129, doi:10.1136/bmj.c5129).

Some of the college’s senior figures were also involved in the Prince of Wales’s complementary health charity, the Foundation for Integrated Health. The foundation closed last year after police launched a theft, fraud, and money laundering inquiry. George Gray, its finance director, was charged with the theft of £250 000 [€280 000; $405 000] and is currently serving a three year prison term.

None of those helping …
Compliance With Patient-Reported Outcomes in Multicenter Clinical Trials: Methodologic and Practical Approaches
Authors: Stephanie R. Land, Marcie W. Ritter, Joseph P. Costantino, Thomas B. Julian, Walter M. Cronin, Sarah R. Haile, Norman Wolmark, Patricia A. Ganz
Journal: Journal of Clinical Oncology (2007)

This report describes interventions undertaken by the National Surgical Adjuvant Breast and Bowel Project (NSABP) to improve compliance with patient-reported outcome (PRO) assessments in the setting of multicenter cancer clinical trials. We describe the effectiveness of several interventions and of observational factors.PRO submission rates were analyzed for the following three NSABP protocols: the Study of Raloxifene and Tamoxifen (STAR), B-32, and B-35. Institutions participating in protocol B-35 were randomly assigned to receive automated reminders of upcoming assessments or not. Compliance was analyzed with a logistic repeated measures mixed modeling.Compliance was high in the three protocols, with rates greater than 80% for nearly all time points. Institutions were a significant source of variability (P < .01). The largest institutions had the highest compliance in STAR (odds ratio [OR] = 0.68 for < 50 participants enrolled and OR = 0.82 for 50 to 99 participants enrolled v larger institutions; P < .001). Midsized institutions had highest compliance in B-32 (OR = 4.63 for 31 to 50 patients enrolled and OR = 3.12 for > 50 patients enrolled v small institutions; P = .007). Compliance increased with participant age in STAR (OR = 0.57, 0.89, and 1.01 for ages < 50, 50 to 60, and 60 to 70 years, respectively, v > 70 years; P < .001). Race was significant in B-32 (OR = 2.63 for white v nonwhite; P < .001) and in STAR (OR = 1.41 for white v nonwhite; P < .001). Treatment group was significant in B-32 (OR = 0.74; P = .006). The B-35 prospective reminder did not improve compliance significantly (P = .30), but in B-32, delinquency sanctions were significant (OR = 1.56; P = .007).Compliance in NSABP PRO studies is higher now than a decade ago. Results for compliance initiatives were mixed. Age and race are important factors, but institutional variation remains significant and largely unexplained.
[573] COMPARISON OF EARLY VIROLOGIC RESPONSE AMONG PATIENTS WITH CHRONIC HEPATITIS C INFECTED WITH GENOTYPE NON 2/3 TREATED WITH PEGYLATED INTERFERON ALFA-2b AND RIBAVIRIN IN DEPENDENCE WITH HEPATIC FIBROSIS STAGES
Authors: H. Berak, A. Kolakowska-Rzadzka, M. Wasilewski, J. Kowalska, I. Stanczak, K. Bardadin, A. Horban
Journal: Journal of Hepatology (2007)
Psychiatry: The Battered Child of Medicine
Authors: Milton Greenblatt
Journal: New England Journal of Medicine (1975)

Psychiatry has had a troubled history. After the French Revolution "moral treatment" brought to America a period of effective and humane hospital treatment, but this progress was corrupted by the Industrial Revolution, and psychiatry was rejected by society as well as by medicine. Although the Freudian enlightenment and the introduction of social psychiatry have led to greater acceptance, today's criticisms are strident. Psychiatry is criticized for imprecise diagnosis, conceptual vagaries, jargon, therapeutic impotence and class bias. The American system of mental-health care is seen by many as a disaster. The federal comprehensive Community Mental Health Act has been aborted at an early stage. Skills involved in the practice of psychotherapy are not unique to the profession. Social ills, over which psychiatry has little control, play a large part in causing mental disability and retardation. Nevertheless, though embattled, psychiatry has contributed to medical practice and to the humane consciousness of society.
Clinical Experience With a Novel Multielectrode Basket Catheter in Right Atrial Tachycardias
Authors: Claus Schmitt, Bernhard Zrenner, Michael Schneider, Martin Karch, Gjin Ndrepepa, Isabel Deisenhofer, Sonja Weyerbrock, Jürgen Schreieck, Albert Schömig
Journal: Circulation (1999)

Background —The complexity of atrial tachycardias (ATs) makes the electroanatomic characterization of the arrhythmogenic substrate difficult with conventional mapping techniques. The aim of our study was to evaluate possible advantages of a novel multielectrode basket catheter (MBC) in patients with AT. Methods and Results —In 31 patients with AT, an MBC composed of 64 electrodes was deployed in the right atrium (RA). The possibility of deployment, spatial relations between MBC and RA, MBC recording and pacing capabilities, mapping performance, and MBC-guided ablation were assessed. MBC deployment was possible in all 31 patients. The MBC was left in the RA for 175±44 minutes. Stable bipolar electrograms were recorded in 88±4% of electrodes. Pacing from bipoles was possible in 64±5% of electrode pairs. The earliest activity intervals, in relation to P-wave onset, measured from the MBC and standard roving catheters were 41±9 and 46±6 ms, respectively ( P =0.21). Radiofrequency ablation was successful in 15 (94%) of 16 patients in whom it was attempted, including 2 patients with polymorphic right atrial tachycardia (RAT), 2 with RAT–atrial flutter combination, 1 with macroreentrant AT, and 1 with focal origin of atrial fibrillation. Conclusions —These data demonstrate that MBC can be used safely in patients with right atrial arrhythmias. The simultaneous multielectrode mapping aids in the rapid identification of sites of origin of the AT and facilitates radiofrequency ablation procedures. The technique is especially effective for complex atrial arrhythmias.
DIAGNOSTIC VALUE OF VASODILATOR-INDUCED LEFT VENTRICULAR DYSSYNCHRONY IN THE DETECTION OF MULTI-VESSEL CORONARY ARTERY DISEASE USING MYOCARDIAL PERFUSION IMAGING
Authors: Hirokazu Tanaka, Taishiro Chikamori, Satoshi Hida, Yuko Igarashi, Chie Shiba, Yasuhiro Usui, Akira Yamashina
Journal: Journal of the American College of Cardiology (2012)
ALBUMIN METABOLISM IN CHILDREN WITH PROTEIN MALNUTRITION1
Authors: David Gitlin, Joaquin Cravioto, Silvestre Frenk, Evangelina L. Montano, Rafael Ramos Galvan, Federico Gomez, Charles A. Janeway
Journal: Journal of Clinical Investigation (1958)

(Group I), while the other 11 children showed definite edema (Group II). Well-developed pellagroid skin lesions of the type seen in protein malnutrition were present in each of the 11 edematous children, but only small atrophic lesions were noted in the other three. Microscopic examination of feces revealed G. lamblia infestation in two children, L. B. F. and R. E. J. Patient J. M. J. died during the study, and postmortem examination revealed, among other things, the presence of bronchopneumonia. Method of study. Each child was given five drops of Lugol's solution three times a day during the study. Within 48 hours of admission, I~-labeled human serum albumin was injected intravenously, and the disappearance of radioactivity from the serum was followed for about three weeks (Period A, Table I) in all patients except J. M. J., who died eight days after the start of the study. After an additional interval of three to four weeks, eight children were given a second injection of radioiodinated albumin, and its disappearance was again followed for
Specific concentration of polynucleotide immune complexes in the cryoprecipitates of patients with systemic lupus erythematosus.
Authors: J B Winfield, D Koffler, H G Kunkel
Journal: Journal of Clinical Investigation (1975)

Although the association of cryoglobulinemia with hypocomplementemia and tissue injury in systemic lupus erythematosus is well recognized, composition of cryoprecipitates in terms of circulating antigens and antibodies in this disease is less clear. To clarify this question, cryoprecipitates from patients with SLE were examined with sensitive assay techniques for certain antipolynucleotide antibodies and DNA antigen. DNA antibodies were highly enriched relative to serum levels in the majority of cryoprecipitates. DNA antigen was also demonstrable. Antibody to ribonucleoprotein, although less frequently present, was similarly enriched in certain cryoprecipitates. In contrast, anti-double strand RNA, which was commonly detectable in relatively high titer in serum, was only minimally concentrated in a minority of cryoprecipitates. Absorption experiments using red blood cells heavily coated with polynucleotide antigen indicated that a major proportion of the IgG in certain cryoprecipitates was specific antibody. The data strongly suggest that the cryoprecipitates in systemic lupus erythematosus represent circulating immune complexes that are soluble at 37 degrees C and come out of solution in the cold. The marked concentration of immune complexes in the cryoglobulin offers a simple and direct method for determination of the nature of the complexes. The accumulated evidence obtained in the present study indicates that these complexes closely reflect, in their composition, the circulating immune complexes which are most significant pathogenetically in renal tissue injury.
Effect of gamma-irradiation on cladribine and cladribine-containing biodegradable copolymers
Authors: Tomasz Kryczka, Barbara Marciniec, Maria Popielarz-Brzezinska, Maciej Bero, Janusz Kasperczyk, Piotr Dobrzyński, Zygmunt Kazimierczuk, Paweł Grieb
Journal: Journal of Controlled Release (2003)
Indian women s groups protest at new contraceptive trial
Authors: R. Sharma
Journal: BMJ (2001)

India's leading women's groups held a noisy demonstration outside the health ministry on World Population day last week against the introduction of contraceptives that they considered hazardous. They also demanded the withdrawal of “coercive” population policies in several states.

It followed the announcement last month by the health minister, C P Thakur, that the long acting injectable contraceptive norethisterone would be introduced on a trial basis in 12 medical college hospitals across India.

But Brinda Karat, general secretary of All India Democratic Women's Organisation, is concerned at the proposals. “The Indian Council of Medical Research had done some trials [of norethisterone] in the early 1980s which were withdrawn precisely because it was found that it was not suitable for Indian conditions,” she said

Women's groups …
711-3-A Multicenter, Randomized, Double-Blind Pilot Trial of Standard Versus Low Dose Weight-Adjusted Heparin in Patients Treated with the Platelet GP IIb/IIIa Receptor Antibody c7E3 During Percutaneous Coronary Revascularization
Authors: A. Michael Lincoff, James E. Tcheng, Theodore A. Bass, Jeffrey J. Popma, Paul S. Teirstein, Neal S. Kleiman, Harlan F. Weisman, Maura H. Musco, Catherine F. Cabot, Lisa G. Berdan, Robert M. Califf, Eric J. Topol
Journal: Journal of the American College of Cardiology (1995)
A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.
Authors: M J Blackman, H G Heidrich, S Donachie, J S McBride, A A Holder
Journal: The Journal of Experimental Medicine (1990)

A complex of polypeptides derived from a precursor is present on the surface of the malaria merozoite. During erythrocyte invasion only a small fragment from this complex is retained on the parasite surface and carried into the newly infected red cell. Antibodies to this fragment will interrupt invasion.
Emergency banding ligation versus sclerotherapy for the control of active bleeding from esophageal varices
Authors: G Lo, K Lai, J Cheng, C Lin, J Huang, P Hsu, H Chiang
Journal: Hepatology (1997)

Active bleeding varices are a great challenge to endoscopists. In this study, we compared the short-term efficacy and safety of banding ligation with injection sclerotherapy in the arresting of active bleeding from esophageal varices. Seventy-one cirrhotic patients with active variceal bleeding were randomized to receive banding ligation (37 patients) or sclerotherapy (34 patients) immediately after endoscopic examinations. Primary success rate (bleeding stopped for 72 hours) was 97% in the ligation group and 76% in the sclerotherapy group ( P = .009). The efficacy of ligation was similar to sclerotherapy in the control of oozing varices (100% vs. 89%, P = .23), whereas ligation was superior to sclerotherapy in the control of spurting varices (94% vs. 62%, P = .012). The requirement of vasoconstrictors after emergency endoscopic treatment was lower in the ligation group than in the sclerotherapy group (11% vs. 41%, P = .007). Treatment failure within 1 month was 8% in the ligation group vs. 30% in the sclerotherapy group ( P = .02). Blood transfusion requirements were significantly lower in the ligation group than in the sclerotherapy group (3.2 ± 1.2 vs. 4.5 ± 1.8 units, P &lt; .01). Rebleeding rate within 1 month was 17% in the ligation group and 33% in the sclerotherapy group ( P = .19). Significant complications were encountered in 5% of the ligation group and 29% of the sclerotherapy group ( P = .007). Mortality rates within 1 month were 19% in the ligation group and 35% in the sclerotherapy group ( P = .19). Banding ligation and sclerotherapy were comparable in the arresting of oozing varices, whereas ligation was superior to sclerotherapy in the control of spurting varices. Patients treated with ligation required fewer vasoconstrictors and fewer transfusion units than patients treated with sclerotherapy. Furthermore, banding ligation was associated with a lower complication rate than sclerotherapy.
Autoimmunity to Uroplakin II Causes Cystitis in Mice: A Novel Model of Interstitial Cystitis
Authors: Cengiz Z. Altuntas, Firouz Daneshgari, Cagri Sakalar, Esen Goksoy, M. Fatih Gulen, Michael Kavran, Jun Qin, Xiaoxia Li, Vincent K. Tuohy
Journal: European Urology (2011)