tbuckley/cabot-search huggingface dataset:
Coexpression of p165 myeloid surface antigen and terminal deoxynucleotidyl transferase: A comparison of acute myeloid leukaemia and normal bone marrow cells
Authors: Kenneth F. Bradstock, Arna Kerr, Arnold Kabral, Emmanuel J. Favaloro, John W. Hewson
Journal: American Journal of Hematology (1986)

Abstract A double immunofluorescence technique, using antibodies to terminal transferase (TdT) and a 165‐kilodalton myeloid differentiation antigen (p165), has been used to investigate the phenomenon of TdT expression in cases of acute myeloid leukaemia (AML). Five cases of AML were shown to have significant (18‐90%) numbers of leukaemic cells that concurrently expressed both TdT and p165 myeloid surface antigen. Examination of nonleukaemic bone marrow cells showed that the vast majority of normal TdT+ cells are p165 negative. However, in 5 of the 11 samples analyzed, rare cells staining for both p165 and TdT were found. These results suggest that some cases of TdT + AML may arise from the clonal expansion of rare “biphenotypic” precursor cells existing in normal bone marrow.
miR-154* and miR-379 in the DLK1-DIO3 MicroRNA Mega-Cluster Regulate Epithelial to Mesenchymal Transition and Bone Metastasis of Prostate Cancer
Authors: Murali Gururajan, Sajni Josson, Gina Chia-Yi Chu, Chia-Lun Lu, Yi-Tsung Lu, Christopher L. Haga, Haiyen E. Zhau, Chunyan Liu, Jake Lichterman, Peng Duan, Edwin M. Posadas, Leland W.K. Chung
Journal: Clinical Cancer Research (2014)

MicroRNAs in the delta-like 1 homolog-deiodinase, iodothyronine 3 (DLK1-DIO3) cluster have been shown to be critical for embryonic development and epithelial to mesenchymal transition (EMT). DLK1-DIO3 cluster miRNAs are elevated in the serum of patients with metastatic cancer. However, the biologic functions of these miRNAs in the EMT and metastasis of cancer cells are poorly understood. We previously demonstrated the oncogenic and metastatic role of miR-409-3p/5p, a member of this cluster, in prostate cancer. In this study, we defined the role of miR-154* and miR-379, two key members of this cluster, in prostate cancer progression and bone metastasis in both cell line models and clinical specimens.Genetic manipulation of miR-154* and miR-379 was performed to determine their role in tumor growth, EMT, and bone metastasis in mouse models. We determined the expression of miR-154* in prostate cancer clinical samples and bone metastasis samples using in situ hybridization and quantum dot labeling.Elevated expression of miR-154* and miR-379 was observed in bone metastatic prostate cancer cell lines and tissues, and miR-379 expression correlated with progression-free survival of patients with prostate cancer. Intracardiac inoculation (to mimic systemic dissemination) of miR-154* inhibitor-treated bone metastatic ARCaPM prostate cancer cells in mice led to decreased bone metastasis and increased survival.miR-154* and miR-379 play important roles in prostate cancer biology by facilitating tumor growth, EMT, and bone metastasis. This finding has particular translational importance because miRNAs in the DLK1-DIO3 cluster can be attractive biomarkers and possible therapeutic targets to treat bone metastatic prostate cancer.
Common genetic variation contributes significantly to the risk of childhood B-cell precursor acute lymphoblastic leukemia
Authors: V Enciso-Mora, F J Hosking, E Sheridan, S E Kinsey, T Lightfoot, E Roman, J A E Irving, I P M Tomlinson, J M Allan, M Taylor, M Greaves, R S Houlston
Journal: Leukemia (2012)
Cardiorespiratory Response to Exercise After Renal Sympathetic Denervation in Patients With Resistant Hypertension
Authors: Christian Ukena, Felix Mahfoud, Ingrid Kindermann, Christine Barth, Matthias Lenski, Michael Kindermann, Mathias C. Brandt, Uta C. Hoppe, Henry Krum, Murray Esler, Paul A. Sobotka, Michael Böhm
Journal: Journal of the American College of Cardiology (2011)
Effects of Airway Exposure to Nanoparticles on Lung Inflammation Induced by Bacterial Endotoxin in Mice
Authors: Ken-ichiro Inoue, Hirohisa Takano, Rie Yanagisawa, Seishiro Hirano, Miho Sakurai, Akinori Shimada, Toshikazu Yoshikawa
Journal: Environmental Health Perspectives (2006)

BackgroundAlthough adverse health effects of particulate matter with a diameter of < 100 nm (nanoparticles) have been proposed, molecular and/or experimental evidence for their facilitation of lung inflammation in vivo is not fully defined.ObjectiveIn the present study we investigated the effects of nanoparticles on lung inflammation related to bacterial endotoxin [lipopolysaccharide (LPS)] in mice.ResultsWe intratracheally administered vehicle, two sizes (14 nm, 56 nm) of carbon black nanoparticles (4 mg/kg), LPS (2.5 mg/kg), or LPS plus nanoparticles and evaluated parameters for lung inflammation and coagulation. Nanoparticles alone induced slight lung inflammation and significant pulmonary edema compared with vehicle. Fourteen-nanometer nanoparticles intensively aggravated LPS-elicited lung inflammation and pulmonary edema that was concomitant with the enhanced lung expression of interleukin-1β (IL-1β), macrophage inflammatory protein-1α (MIP-1α), macrophage chemoattractant protein-1, MIP-2, and keratinocyte chemoattractant in overall trend, whereas 56-nm nanoparticles did not show apparent effects. Immunoreactivity for 8-hydroxyguanosine, a marker for oxidative stress, was more intense in the lungs from the LPS + 14-nm nanoparticle group than in those from the LPS group. Circulatory fibrinogen levels were higher in the LPS + plus 14-nm nanoparticle group than in the LPS group.ConclusionsTaken together, evidence indicates that nanoparticles can aggravate lung inflammation related to bacterial endotoxin, which is more prominent with smaller particles. The enhancement may be mediated, at least partly, via the increased local expression of proinflammatory cytokines and via the oxidative stress. Furthermore, nanoparticles can promote coagulatory disturbance accompanied by lung inflammation.
Comparison of Visual Acuity in Macular Degeneration Patients Measured with Snellen and Early Treatment Diabetic Retinopathy Study Charts
Authors: Iryna A. Falkenstein, Denine E. Cochran, Stanley P. Azen, Laurie Dustin, Ajay M. Tammewar, Igor Kozak, William R. Freeman
Journal: Ophthalmology (2007)
Expression of Lacto Series Type 2 Antigens in Human Renal Cell Carcinoma and Its Clinical Significance
Authors: Y. Fukushi, H. Ohtani, S. Orikasa
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Expression of Lacto Series Type 2 Antigens in Human Renal Cell Carcinoma and Its Clinical Significance Get access Yasuo Fukushi, Yasuo Fukushi * *Correspondence to: Dr. Y. Fukushi, Department of Urology, Tohoku University, School of Medicine, 1–1, Seiryo-machi, Sendai 980, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Haruo Ohtani, Haruo Ohtani Search for other works by this author on: Oxford Academic PubMed Google Scholar Seiichi Orikasa Seiichi Orikasa Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 5, 1 March 1989, Pages 352–358, https://doi.org/10.1093/jnci/81.5.352 Published: 01 March 1989 Article history Received: 24 June 1988 Revision received: 17 November 1988 Accepted: 08 December 1988 Published: 01 March 1989
PWE-042 Colonoscopy Quality Measures: Experience from a Welsh Bowel Cancer Screening Centre: Abstract PWE-042 Table 1
Authors: J J Hurley, A B Hawthorne, J Torkington, J Green, S Dolwani
Journal: Gut (2013)

<h3>Introduction</h3> The NHS Bowel Cancer Screening Programme (BCSP) in England has demonstrated high quality colonoscopy [1]. Bowel Cancer Screening in Wales began in October 2008. We report results of first 3 years of screening in a single Welsh centre. Comparison is made with results from the English BSCP. <h3>Methods</h3> Data was collected prospectively for participants undergoing FOBt testing and colonoscopy or flexible sigmoidoscopy between October 2009 and December 2011 in Cardiff and the Vale of Glamorgan. Quality indicators were calculated where appropriate. Adenomas were confirmed after correlation with histopathology reports. with no adenoma double counted. <h3>Results</h3> 42630 faecal occult blood test kits were returned from 91414 sent (46.6%), leading to 933 colonoscopies (795 index) and 82 flexible sigmoidoscopies (not index but mostly for therapeutic procedures) undertaken by four accredited screeners. Mean ADR per colonoscopist was 54.1%, mean number of adenomas per procedure (MAP) was 1.24 and the mean adenomas per positive procedure (MAP+) was 2.3, with a mean polyp retrieval rate of 98%. Mean midazolam dose was 2 mg (range 0.5–4 mg) and fentanyl 50mcg (range 25–100 cmg). Hyoscine n-butyl bromide was used in 34.5% of cases, with no increased ADR (p = 1.000). Only 2% of patients reported severe discomfort. Bowel cancer was detected in 69 individuals; a positive predictive value of colonoscopy (after positive FOBt) of 8.7%. <h3>Conclusion</h3> Our centre is providing high quality colonoscopy, with statistically significant higher rates of adenoma detection in both the index and prevalent rounds of screening colonoscopies compared to data from the English BCSP, and a low rate of adverse events given an increased need for endoscopic therapy. Measures of total adenoma detection (MAP and MAP+) also compare favourably. Further information is required to ascertain the clinical outcome measure of the missed cancer rate following a screening colonoscopy within the BSCP across the UK. <h3>Disclosure of Interest</h3> None Declared. <h3>Reference</h3> Lee TJW<i> et al.</i> Colonoscopy quality measures: experience from the NHS Bowel Cancer Screening Programme. Gut 2011; 61: 1050–7
SIADH in a Patient Receiving Sertraline
Authors: Daniel D. Bluff
Journal: Annals of Internal Medicine (1995)

Letters15 November 1995SIADH in a Patient Receiving SertralineDaniel D. Bluff, MD and Ngozi Oji, MDDaniel D. Bluff, MDSt. John's Episcopal Hospital; Far Rockaway, NY 11691 and Ngozi Oji, MDSt. John's Episcopal Hospital; Far Rockaway, NY 11691Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-10-199511150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Selective serotonin re-uptake inhibitors are better tolerated than older antidepressant agents but are associated with side effects of which internists may not be aware. One such side effect is the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Life-threatening hyponatremia due to SIADH has been described with both fluoxetine (Prozac, Dista Products Co., Indianapolis, Indiana) [1] and paroxetine (Paxil, SmithKline Beecham Pharmaceuticals, Pittsburgh, Pennsylvania) [2]. Recently, several reports in the psychiatric literature have described the occurrence of SIADH due to another selective serotonin reuptake inhibitor, sertraline (Zoloft, Roerig, New York, New York) [3-5]. We describe an additional case ...References1. Kazal LA, Hall DL, Miller LG, Noel ML. Fluoxetine-induced SIADH: a geriatric occurrence? J Fam Pract. 1993; 36:341-3. Google Scholar2. Chua TP, Vong SK. Hyponatremia associated with paroxetine. BMJ. 1993; 306:143. Google Scholar3. Llorente MD, Gorelick M, Silverman MA. Sertraline as the cause of inappropriate antidiuretic hormone secretion. J Clin Psychiatry. 1994; 55:543-4. Google Scholar4. Thornton SL, Resch DS. SIADH associated with sertraline therapy [Letter]. Am J Psychiatry. 1995; 152:809. Google Scholar5. Jackson C, Carson W, Markowitz J, Mintzer J. SIADH associated with fluoxetine and sertraline therapy. Am J Psychiatry. 1995; 152:809-10. Google Scholar Author, Article, and Disclosure InformationAffiliations: St. John's Episcopal Hospital; Far Rockaway, NY 11691 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA case of fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretionHyponatremia Associated with Selective Serotonin-Reuptake Inhibitors in Older AdultsHyponatraemia Associated with Psychotropic MedicationsEffect of Paroxetine on Plasma Vasopressin and Water Load Testing in Elderly IndividualsHyponatremia with VenlafaxineDrug Information RoundsSertraline 15 November 1995Volume 123, Issue 10Page: 811-811KeywordsEdemaHyponatremiaIschemiaSaline solutionsSelective serotonin reuptake inhibitorsSerotoninSodiumSyndrome of inappropriate antidiuretic hormone secretionUrineVital signs ePublished: 15 August 2000 Issue Published: 15 November 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Information technology and patient care: who, when and why
Authors: P. Granat
Journal: JAMA (1993)

To  Editor.  —The conclusion of Dr Rootenberg's 1 article that the future of health care provision rests with practice guidelines and outcomes analyses in managed care settings is debatable.  Clinical input cannot be truly measured; use of technology to manage information is not what clinical thought and action are about. Should it come to pass, we are all at great peril. Medicine by algorithm will slide backward, become robotic, devoid of creativity, humanity, commitment, and perspicacity.  Clinicians, acting and reacting daily in  trenches, depend on keeping up with new knowledge. Print material is fast and transportable and conferences offer collegiality. Computer updates can lag behind print material. Many items do not make it to  supposedly comprehensive databases.  In  academic center, tertiary specialists peer down narrow tunnels looking for  light of integrated medical reality while doing heroic work. They treat many inner-city patients, where outcomes may
About Diploma Mills.
Authors: W. Ryno
Journal: JAMA (1897)

Benton Harbor, Mich., Jan. 22, 1897. <h3>To the Editor:</h3> —I understand the charter of the Illinois Health University has been annulled, but you will see that the same J. Armstrong, Mary E. Sellers, Demuheller &amp; Co. are in another "mill" of the same sort, and have supplied their graduates here with diplomas from the "Independent Medical College," which is run on exactly the same rules as their other "mill." It seems that your State officers will allow this same company of confidence men to carry on their nefarious business regardless of anything or anybody; in fact it appears as though they were aids and abettors in their transactions. What can be done about it? Very respectfully,
Opioid Doses and Increased Risk for Overdose
Authors: Milap C. Nahata
Journal: Annals of Internal Medicine (2010)

Letters6 July 2010Opioid Doses and Increased Risk for OverdoseMilap C. Nahata, PharmD, MS and Katy E. Trinkley, PharmDMilap C. Nahata, PharmD, MSFrom Ohio State University, Columbus, OH 43210.Search for more papers by this author and Katy E. Trinkley, PharmDFrom Ohio State University, Columbus, OH 43210.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-1-201007060-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We commend Dunn and colleagues (1) on their findings of a dose–response relationship between opioid dose and overdose risk. Although some participants misused opioids, most had not received opioids for at least 6 months. The authors found that opioid doses of 20 mg/d were associated with lower potential for overdose than higher doses. The daily doses reported were the cumulative dose dispensed over 90 days, divided by 90, with no indication of the prescribed duration. All participants filled at least 3 opioid prescriptions, but the daily supply was not reported. This may lead to misinterpretation of their ...Reference1. Dunn KM, Saunders KW, Rutter CM, Banta-Green CJ, Merrill JO, Sullivan MD, et al. Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med. 2010;152:85-92. [PMID: 20083827] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Ohio State University, Columbus, OH 43210.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOpioid Prescriptions for Chronic Pain and Overdose Kate M. Dunn , Kathleen W. Saunders , Carolyn M. Rutter , Caleb J. Banta-Green , Joseph O. Merrill , Mark D. Sullivan , Constance M. Weisner , Michael J. Silverberg , Cynthia I. Campbell , Bruce M. Psaty , and Michael Von Korff Opioid Doses and Increased Risk for Overdose Michael Von Korff and Kate Dunn Opioid Doses and Increased Risk for Overdose William C. Becker , David A. Fiellin , and Robert D. Kerns Metrics 6 July 2010Volume 153, Issue 1Page: 59KeywordsConflicts of interestMorphineOpioids ePublished: 6 July 2010 Issue Published: 6 July 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Multifocal small-bowel carcinoid tumor causing obscure recurrent gastrointestinal bleeding diagnosed by capsule endoscopy
Authors: S. Nathan, L. Biernat, D. Tang
Journal: Endoscopy (2007)

A 38-year-old woman presented to our hospital with a 2-day history of passing black tarry stools. She had a history of recurrent obscure gastrointestinal bleeding, manifested by hematochezia and iron-deficiency anemia for 2 years, and had had six negative upper endoscopies and six negative colonoscopies prior to this presentation. A small-bowel series and computed tomography of the abdomen were both negative. Because conventional studies failed to find a source of bleeding and because the bleeding persisted, the patient was referred for a small-bowel video capsule endoscopy (Given Imaging Ltd., Yoqneam, Israel). The study was limited due to prolonged retention of the capsule in the stomach but nevertheless it revealed multiple submucosal masses in the distal ileum, some of which were umbilicated and ulcerated, with stigmata of recent bleeding ([Fig. 1], Videos 1, 2).
Pharyngeal Mass in a Patient with B-Cell Lymphoma
Authors: Chung-Ching Hung, Jih-Chin Lee
Journal: New England Journal of Medicine (2009)

An 84-year-old man presented with an isolated sensation of a lump in the back of his throat and difficulty swallowing that had developed over several months. A year earlier, the patient had received a diagnosis of lymphoma involving the inguinal lymph nodes, which had been treated with CHOP combination therapy (cyclophosphamide, doxorubicin, vincristine, and prednisone). This therapy resulted in a partial remission of the lymphoma. The physical examination revealed a mass in the posterior oropharynx. Cervical and inguinal lymphadenopathy were present; there was no hepatosplenomegaly, and the peripheral-blood smear was normal. Endoscopy revealed a large pharyngeal mass on the right . . .
Endorses Dr. Cohen et alii.
Authors: Wm. P. Munn
Journal: JAMA (1894)

Denver, Col., March 19, 1894. <h3>To the Editor:</h3> —There are members of theAssociationoutside of Pennsylvania who indorse most cordially Dr. Cohen's recent criticism of the policy of theJournalin regard to advertisements of proprietary articles. I, for one, give an unqualified assent to all that he has said, and in addition consider the editorial attitude of the<i>Medical News</i>and the<i>Pittsburg Medical Review</i>most commendable. They take the only stand that honorable adherents of our Code of Ethics can take. Very respectfully,
Health Care Changes After Independence and Transition to Majority Rule
Authors: Michele Barry
Journal: JAMA (1990)

Barry, et al. analyze Zimbabwe (formerly Southern Rhodesia) as a regional role model to assess the impact on health care of the transition to independence and black majority rule. Colonized by the British in 1890, Zimbabwe gained independence and majority rule in 1980. The authors describe health care under colonialism and outline the changes that have come about since 1980 in health policy, in the health care sector, and in the health status of the black population, especially women and infants. They also describe the socioeconomic and political factors that challenge the postindependence government's goal of achieving equality in health care and health status between blacks and whites, and between urban and rural dwellers.
Towards an immunoscore for triple negative breast cancer (TNBC): lymphocytic infiltrate predicts outcome
Authors: Sylvia Adams, Robert Gray, Sandra Demaria, Lori J Goldstein, Edith A Perez, Lawrence N Shulman, Silvana Martino, Nancy E Davidson, George W Sledge, Joseph A Sparano, Sunil Badve
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Efforts are ongoing to further classify solid tumors by immunoscores, which have prognostic implications and may also have predictive value and identify targets for novel therapies to increase cure rates. TNBC are highly aggressive breast cancers, which are frequently infiltrated
Color Textbook of Pediatric Dermatology, 3rd edn.
Authors: Aileen Taylor
Journal: British Journal of Dermatology (2003)

Journal Article Color Textbook of Pediatric Dermatology, 3rd edn. Get access Aileen Taylor Aileen Taylor Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 148, Issue 2, 1 February 2003, Page 383, https://doi.org/10.1046/j.1365-2133.2003.05097_18.x Published: 01 February 2003
Anticonvulsant Effects of Local Anesthetics
Authors: Walter B. Essman
Journal: JAMA (1978)

To the Editor.—  The communication concerned with the Toxic Effects of Local Anesthetics by Rudolph H. de Jong, MD (239:1166, 1978), briefly reviews some of the CNS effects of these agents and suggests that convulsions may be one consequence of increased levels made available to the brain. It should be noted, however, that in lower dose these same local anesthetics, rather than being proconvulsants or decreasing seizure threshold, serve as anticonvulsants1; this effect has been observed in the use of intravenous lidocaine in controlling status epilepticus in man, attenuating electrically-induced seizures in man,2and blocking auditory convulsions in animals.3  Certainly there is a considerable overlap between the therapeutic range of such a local anesthetic as lidocaine in the treatment of ventricular arrhythmias and ventricular tachycardia and the clinical efficacy, within the same dose range, of this agent as an anticonvulsant.
Oxybate Sodium For Parkinsonism
Authors: P.S. Papavasiliou
Journal: JAMA (1973)

To the Editor.—  One of the explanations for the symptomatic improvement of parkinsonism by levodopa is that striatal dopamine, 1 which is abnormally low in the brains of untreated patients 2 becomes repleted. Since, however, the striatum is not the only cerebral site capable of dopamine synthesis, it was thought that cerebral side effects of levodopa might be due to ectopically produced dopamine. 3 Increases of dopamine exclusively in the striatum have been reported following administration of oxybate sodium to animals. 4-6 Intravenous injections of this substance, furthermore, have improved the tremor, the rigidity, and the akinesia of patients with parkinsonism. 7 These facts might assume therapeutic importance if oral administration of oxybate sodium improved the symptoms in otherwise untreated parkinsonian patients or in those receiving levodopa with suboptimal results. Such a trial is reported here.  Eight patients with idiopathic parkinsonism and one with postencephalitic disease were admitted into a