Angiotensin-induced Natriuresis in Cirrhosis in the Absence of Endogenous Aldosterone Secretion
Authors: RANDOLPH M. MCCLOY
Journal: Annals of Internal Medicine (1966)

Case Studies1 June 1966Angiotensin-induced Natriuresis in Cirrhosis in the Absence of Endogenous Aldosterone SecretionRANDOLPH M. MCCLOY, M.D., WILLIAM P. BALDUS, M.D., W. H. J. SUMMERSKILL, D.M., FRANK T. MAHER, M.D., F.A.C.P.RANDOLPH M. MCCLOY, M.D.Search for more papers by this author, WILLIAM P. BALDUS, M.D.Search for more papers by this author, W. H. J. SUMMERSKILL, D.M.Search for more papers by this author, FRANK T. MAHER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1271 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFluid retention accompanying advanced cirrhosis is characterized by secondary hyperaldosteronism and increased reabsorption of sodium by the kidney; the nature of the stimulus to increased aldosterone production is uncertain. The augmentation of aldosterone secretion in health resulting from infusion of angiotensin suggests that the latter may function as a trophic hormone for aldosterone (1-3). Whereas infusion of angiotensin causes sodium retention in normal man, patients with cirrhosis may exhibit a natriuretic and diuretic response (2). This paradoxical effect of angiotensin on sodium excretion in cirrhosis has not been explained. An opportunity to investigate the effects of angiotensin on renal function...References1. LARAGH JH: Interrelationships between angiotensin, norepinephrine, epinephrine, aldosterone secretion, and electrolyte metabolism in man. Circulation 25: 203, 1962. CrossrefMedlineGoogle Scholar2. LARAGHCANNONBENTZELSICINSKIMELTZER JHPJCJAMJI: Angiotensin II, norepinephrine, and renal transport of electrolytes and water in normal man and in cirrhosis with ascites. J. Clin. Invest. 42: 1179, 1963. CrossrefMedlineGoogle Scholar3. 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Author, Article, and Disclosure InformationAffiliations: From the Gastrointestinal Research Unit, Section of Medicine, and Section of Clinical Pathology, Mayo Clinic and Mayo Foundation, and the Mayo Graduate School of Medicine, Rochester, Minn.This study was supported in part by research grant AM-06908, National Institutes of Health, Bethesda, Md.Dr. McCloy was the recipient of grant AM-5259, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to 200 First St. S.W., Rochester, Minn. 55901. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInappropriately low angiotensin II generation: a factor determining reduced kidney function and survival in patients with decompensated cirrhosis 1 June 1966Volume 64, Issue 6Page: 1271-1276KeywordsAldosteroneCirrhosisDiureticsExcretionGraduate medical educationHormonesKidneysNatriuretic peptidesResearch grantsSodium Issue Published: 1 June 1966 PDF DownloadLoading ...