tbuckley/cabot-search huggingface dataset:
AN ALLERGY SURVEY
Authors: Nathan Schaffer
Journal: JAMA (1949)

<h3>To the Editor:—</h3> The New Jersey Allergy Society has formed a committee on aerobiology to do an air survey of the state of New Jersey for the purpose of finding allergenic factors not presently recognized. The work will be done in the following fields: (1) pollen surveys, (2) bacteria surveys, (3) fungi surveys, (4) chemical contaminants and (5) meteorology. With funds supplied by Schering Laboratories, six Wells air centrifuges will be set up in widely separated sites in the state. Daily air specimens will be studied. The chairmen for the entire project are Drs. Nathan Schaffer of East Orange, and Edward E. Seidman, of Plainfield. Subchairmen are as follows: Pollen, Dr. L. Byck, Newark. Bacteria, Dr. E. Seidman, Plainfield. Fungi, Dr. N. Schaffer, East Orange. Chemical contaminants, Dr. C. Weston, Glen Ridge. Meteorology, Dr. F. Rosen, Newark. The subcommittee on mycology, which consists of Drs.
Increased adherence of sickled and phosphatidylserine-enriched human erythrocytes to cultured human peripheral blood monocytes.
Authors: R S Schwartz, Y Tanaka, I J Fidler, D T Chiu, B Lubin, A J Schroit
Journal: Journal of Clinical Investigation (1985)

The precise mechanism by which sickle erythrocytes (RBC) are removed from the circulation is controversial, although it is possible that enhanced recognition of these cells by circulating mononuclear phagocytes could contribute to this process. We investigated this possibility by interacting sickle cells with cultured human peripheral blood monocytes. Our results show that both irreversibly sickled cells (ISC) and deoxygenated reversibly sickled cells (RSC) had a higher avidity for adherence to monocytes than did oxygenated sickle and normal RBC. ISC were the most adherent cell type. Adherence of RSC to monocytes was found to be reversible; reoxygenation of deoxygenated RSC resulted in a significant decrease in RSC--monocyte adherence. Concomitant with alterations in sickle RBC adherence were alterations in the organization and bilayer distribution of membrane phospholipids in these cells. Specifically, enhanced adherence was associated with increased exposure of RBC membrane outer leaflet phosphatidylserine (PS) and phosphatidylethanolamine, whereas lack of adherence was associated with normal patterns of membrane phospholipid distribution. To investigate the possibility of whether the exposure of PS in the outer membrane leaflet of these cells might be responsible for their recognition by monocytes, the membranes of normal RBC were enriched with the fluorescent PS analogue 1-acyl-2[(N-4-nitro-benzo-2-oxa-1,3-diazole)aminocaproyl]-phosphatidy lse rine (NBD-PS) via transfer of the exogenous lipid from a population of donor phospholipid vesicles (liposomes). RBC enriched with NBD-PS exhibited enhanced adherence to monocytes, whereas adherence of RBC enriched with similar amounts of NBD-phosphatidylcholine (NBD-PC) was not increased. Furthermore, preincubation of monocytes with PS liposomes resulted in a approximately 60% inhibition of ISC adherence to monocytes, whereas no inhibition occurred when monocytes were preincubated with PC liposomes. These findings strongly suggest that erythrocyte surface PS may be a ligand recognized by receptors on human peripheral blood monocytes and that abnormal exposure of PS in the outer leaflet of the RBC membrane, as found in sickle RBC, might serve to trigger their recognition by circulating monocytes. Our results further suggest that abnormalities in the organization of erythrocyte membrane phospholipids may have significant pathophysiologic implications, possibly including shortened cell survival.
Norwegian scabies and herpes simplex in a patient with chronic lymphatic leukaemia and hypogrammaglobulinaemia
Authors: C.J. Tibbs, D.J. Wilcox
Journal: British Journal of Dermatology (1992)

Journal Article Norwegian scabies and herpes simplex in a patient with chronic lymphatic leukaemia and hypogrammaglobulinaemia Get access C.J. Tibbs, C.J. Tibbs St Richard's Hospital, Chichester, W. Sussex, U. K. Search for other works by this author on: Oxford Academic Google Scholar D.J. Wilcox D.J. Wilcox St Richard's Hospital, Chichester, W. Sussex, U. K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 126, Issue 5, 1 May 1992, Pages 523–524, https://doi.org/10.1111/j.1365-2133.1992.tb11831.x Published: 01 May 1992
THE ROLE OF THE ENDOTHELIUM IN INFLAMMATION.
Authors: E. R. LE COUNT
Journal: JAMA (1901)

It would certainly be superfluous before a body of representative pathologists to give a review of those publications which from time to time for the last forty years have considered the exact position the endothelial cells should occupy as regards their origin and classification. Indeed, the discussion began somewhat earlier, for Henle in a paper on the distribution of epithelium in the human body, written in 1838, noted certain facts which seemed to him to presage a change of ideas regarding the cells that line serous cavities. Not only has the discussion continued until the present time, but it is by no means ended; its very existence furnishes a good illustration of the unity of the sciences pertaining to medicine, for investigators in single branches are unable to harmonize the results of their own researches with those made in other departments; it is also often apparent that there is not
The Injuries to JFK
Authors: Gary L. Aguilar
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Rather than quell doubts about President Kennedy's autopsy findings, I fear that Drs Humes' and Boswell's<sup>1,2</sup>remarks in<i>JAMA</i>will only serve to heighten the level of disbelief in their observations. Neither Humes nor Boswell addressed their critics on contradictory evidence that subsequent government investigations have consistently revealed, namely, that neither the available photographs nor the roentgenograms support Humes' and Boswell's claims regarding the entrance location of the fatal skull wound. At least three qualified groups have reviewed the roentgenographic and photographic evidence and are unanimous in claiming that Humes' and Boswell's claims in the Warren Commission Report erred in placing the fatal skull entrance wound at the base of the skull just above the hairline ("2.5 cm to the right and slightly above the external occipital protuberance" according to Humes both in the<i>JAMA</i>interview, and before that, in his Warren Commission testimony). The Clark
POISONING BY SHOE DYE
Authors: R. E. Cloud
Journal: JAMA (1922)

Nellie M., aged 3 years, had her shoes dyed at 5 o'clock in the afternoon. At 8 the same evening, the mother noticed some blueness of the lips, and at 8: 30, when I saw her, her appearance was alarming; the face and hands were very pale, and the lips and finger nails markedly cyanotic. The child was irritable and behaved as if tired. The pulse was 134, heart action regular but agitated, and there was a systolic murmur, heard all over the precordium. The temperature apparently was not elevated, and there were no respiratory or gastro-intestinal symptoms. The eyes, mouth and throat were negative except for cyanosis of the lips and tongue. During examination, the odor from the freshly dyed shoes was very noticeable. With fresh air and rest in bed during the night, the cyanosis gradually cleared up, and the next morning the appearance and condition of the
Avandia panel member may be investigated for possible conflicts of interest
Authors: J. H. Tanne
Journal: BMJ (2010)

The US Food and Drug Administration has asked its parent department to investigate possible conflicts of interest relating to one of the members of the panel that recently recommended further restrictions on the drug rosiglitazone (marketed as Avandia), manufactured by GlaxoSmithKline (GSK) and used to control type 2 diabetes ( BMJ 2010;341:c3862, 16 Jul, doi:10.1136/bmj.c3862). 

After an internal review of disclosure forms the FDA asked the Office of the Inspector General of the Department of Health and Human Services to investigate disclosure or non-disclosure of conflicts of interest by the panel member David …
Acetaminophen Hepatotoxicity, Fasting, and Ethanol
Authors: Edward B. Nelson
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The recent study by Drs Whitcomb and Block<sup>1</sup>and the accompanying Editorial by Dr Strom<sup>2</sup>are an instructive perspective on the adverse-events profile of acetaminophen. When viewed in the context of the long history of acetaminophen use by patients with a wide variety of medical problems, their results serve to emphasize the remarkable safety profile of acetaminophen when used within dosing instructions. The observations of Whitcomb and Block are consistent with those previously known. Patients at highest risk for an adverse experience to any drug are those who are severely ill or malnourished, who consume excess amounts of alcohol, and who either acutely or chronically exceed recommended doses of the drug. Various combinations of these can be particularly troublesome. Despite the millions of patients with a multitude of medical problems who are consuming acetaminophen daily, these events are rare. Strom provides a compelling discussion of
Alistair John Robertson
Authors: Alan Evans
Journal: BMJ (2008)

Born in Aberdeen in 1950, Alistair John Robertson excelled academically at Aberdeen Grammar School and proceeded to read medicine at Aberdeen University in 1969.As an undergraduate he continued to impress, and having secured prizes in anatomy in first and second year he was offered the opportunity to spend an additional year studying for a bachelor’s degree in medical biology. He seized this offer but chose to spend this extra year studying pathology. He joined a department replete with young talented doctors at a time when pathology was in transition from a descriptive discipline to a subject attempting to explain the aetiology and development of disease processes at the cellular level. This year was very well spent as it stimulated his lifelong interest in pathology. He obtained the degree of BMedBiol with honours before returning to the mainstream medical class, collecting the Russell medal in pathology and bacteriology en route to graduating MB ChB with commendation in 1975.

After graduating, he completed pre-registration house jobs …
Prohibition or Coffee Shops: Regulation of Amphetamine and Methylphenidate for Enhancement Use by Healthy Adults
Authors: Veljko Dubljević
Journal: The American Journal of Bioethics (2013)

This article analyzes appropriate public policies for enhancement use of two most important stimulant drugs: Ritalin (methylphenidate) and Adderall (mixed amphetamine salts). The author argues that appropriate regulation of cognition enhancement drugs cannot be a result of a general discussion on cognitive enhancements as such, but has to be made on a case-by-case basis. Starting from the recently proposed taxation approach to cognition enhancement drugs, the author analyzes available, moderately permissive models of regulation. After a thorough analysis of relevant characteristics of methylphenidate and amphetamine, the author concludes that a moderately liberal permissive regulation of enhancement use by healthy adults might be appropriate for extended release forms of methylphenidate. However, due to their danger profile, amphetamine and instant release forms of methylphenidate should not be made readily available to healthy adults and would need to be prohibited.
High-Pressure Oxygen as an Adjunct in Experimental Bacteremic Shock
Authors: Robert Ollodart
Journal: JAMA (1965)

Septic shock is a syndrome resulting from sepsis, usually gram-negative bacilli invading the blood stream. It is the result of a complex interaction between host and parasite. The mortality in this syndrome is high and any adjunct which may directly benefit the host or discourage the bacteria might be of eventual clinical value. High-pressure oxygen (OHP) has reduced the mortality in a modified Fine hemorrhagic shock preparation from 70% to 20%, presumably by making more oxygen available to the tissues through physical solution in water.<sup>1</sup>In a bacteremic shock preparation utilizing canine fecal peritonitis, OHP merely delayed the onset of some of the biochemical harbingers of severe shock, such as an increasing arterial-venous oxygen difference.<sup>2</sup>The following study was developed to further investigate the possible role of OHP in septic shock with emphasis on the known effects on aerobic-facultative anaerobic gram-negative bacteria.<sup>3-7</sup> <h3>Materials and Methods</h3><h3>In Vitro</h3>
Coexistent Multiple Myeloma and Parathyroid Adenoma
Authors: Reginald C. Chisholm
Journal: JAMA (1982)

To the Editor.—  In the article entitled Coexistent Multiple Myeloma and Primary Hyperparathyroidism (1982; 247:823), Stone et al stated that they were not aware of any other report of a patient in whom overt myeloma and documented primary hyperparathyroidism occurred simultaneously.  We wish to point out that we published a case report1describing an elderly man with simultaneous parathyroid adenoma andκlight-chain myeloma. The patient's clinical presentation was characterized by pathological fractures, cystic bone lesions, and hypercalcemia. He survived for 22 months after resection of the adenoma and institution of chemotherapy of the myeloma. He eventually died of refractory hypercalcemia.  As the authors observed, literature reports of the simultaneous occurrence of symptomatic myeloma and hyperparathyroidism are sparse. We support their recommendation that in the differential diagnosis of hypercalcemia, the coexistence of these diseases should be considered.
Ephedrine and Related Substances.
Authors: K. K. Chen, Carl F. Schmidt
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus
Authors: Erhard van der Vries, Foekje F. Stelma, Charles A.B. Boucher
Journal: New England Journal of Medicine (2010)

N o v . 1 1 , 2 0 0 9 D e c . 3 , 2 0 0 9 D e c . 2 3 , 2 0
Determining Factors in Migration and Adaptation of Mexican Psychiatrists to the United States: A Mexican Viewpoint
Authors: GUIDO BELSASSO, LUIS LARA TAPIA, HÉCTOR LARA TAPIA
Journal: American Journal of Psychiatry (1970)

The authors discuss their study of the 100 Mexican psychiatrists who have trained in the United States; only 46 have returned to Mexico. Factors in their failures to return include the greater financial and professional opportunities outside Mexico, poor personal ties in Mexico, and marriage to a non-Mexican.
Diabetes, aging, and their tissue complications
Authors: Rick Bucala
Journal: Journal of Clinical Investigation (2014)

The inactivation of NO by advanced glycation endproducts (AGEs), which accumulate on tissue proteins as a function of age and hyperglycemia, focused attention on the role of these ubiquitous posttranslational modifications in acquired impairments of vascular reactivity and other signaling processes. This observation occurred during a watershed period of basic and translational research in glycation that encompassed new pathologic phenomena and novel intervention strategies. How has the AGE paradigm for the tissue complications of aging and diabetes fared since the identification of the link between these glycation products and NO inactivation, and what lessons may be offered for future investigations?
CAESAREAN SECTION: With Special Reference to Present-day Indications for Operation
Authors: C. J. G. Taylor
Journal: BMJ (1922)

Frequency of Pulmonary Signs.Since my attention was attracted to the presence of basal congestion in biliary infections I have operated on 31 acute cases.In 8 of these there is no note of an examination of the bases; of the remaining 23 crepitations were noted at the right base in 12, in 11 the examination was negative.In two cases pleural friction was present in addition to the moist sounds.Influence on Prognosis.In no case did any pneumonic complication follow opera- tion.In one case a pleurisy with effusion was found on the day following tbe removal of a gall-bladder full of pus.The bases of the lungs had not been examined in this case prior to operation, otherwise some abnormal physical signs would doubtless have been discovered, There was no death in the series of 31 cases.In 24 cases ether anaesthesia was used, in 7 chloroform. Conclusions.The conclusions to be drawn from the study of these cases are:1.That in a patient complaining of pain at the right costal margin and round the right side of the chest the discovery of crepitations or even of pleural friction at the right base ddes not preclude, but may support, the diagnosis of an acute biliary infection.2. That such pulmonary signs are secondary to the biliary infection, and, far from contraindicating operation, will be effectively treated by dealing surgically with the primary focus of disease.
Biochemical tests for acute pancreatitis.
Authors: I A Bouchier
Journal: BMJ (1985)

be offered-but fortunately they are all that is needed.Especially after a minor head injury the symptom is self limiting, though it may take up to two years to disappear and sometimes never does.When dealing with adolescents the normal child-parent conflicts should be identified and not attributed to the head injury, even though parents might often wish this were the case.Brain tumours, especially those of the frontal lobe, may lead to personality changes which include irritability.This rarely happens in isolation, however, but is usually asso- ciated with other frontal lobe behavioural changes.Temporal lobe abnormalities may also produce various types of aggressive behaviour, but even here irritability is unusual."We need to remember, then, that irritability is not necessarily abnormal.When it is it is often clearly associated with neuronal damage, usually from a head injury-but it is rarely the sole feature of an intracranial organic lesion.Reassurance, time, and sympathy are the main props of treatment.Even so, many patients will continue with symptoms for some considerable time, possibly indefinitely.Fortunately, irritability is not a debilitating disease.
The Process of Compensation and some of its Bearings on Prognosis and Treatment
Authors: B. Bramwell
Journal: BMJ (1888)

tion-namely, to split the tongue down the middle, to loosen it from all its attachments beneath, and then divide with the dcraseur far b.ack, taking one-half of the tongue at a time.Of course in nianny cases you remove only half; it is not necessary to remove tlle vliole.lWe hlave most of us now given up that operation and gone to the iiitrabuccal operation with the scissors, generally
Quality of care in the NHS of England
Authors: Sheila Leatherman, Kim Sutherland
Journal: BMJ (2004)

<h3>Objectives</h3> Globally, there is emerging evidence on the use of community health workers and volunteers in low-income and middle-income settings for the management of non-communicable diseases (NCDs), provision of out-of-clinic screening, linkage with health services, promotion of adherence, and counselling on lifestyle and dietary changes. Little guidance exists on the role of this workforce in supporting NCD care for refugees who lack access to continuous care in their host country. The goals of this work were to evaluate the current roles of community health volunteers (CHVs) in the management of diabetes and hypertension (HTN) among Syrian refugees and to suggest improvements to the current primary care model using community health strategies. <h3>Setting and participants</h3> A participatory, multistakeholder causal loop analysis workshop with representatives from the Ministry of Health of Jordan, non-governmental organisations, United Nations agencies, CHVs and refugee patients was conducted in June 2019 in Amman, Jordan. <h3>Primary outcome</h3> This causal loop analysis workshop was used to collaboratively develop a causal loop diagram and CHV strategies designed to improve the health of Syrian refugees with diabetes and HTN living in Jordan. <h3>Results</h3> During the causal loop analysis workshop, participants collaboratively identified and mapped how CHVs might improve care among diagnosed patients. Possibilities identified included the following: providing psychosocial support and foundational education on their conditions, strengthening self-management of complications (eg, foot checks), and monitoring patients for adherence to medications and collection of basic health monitoring data. Elderly refugees with restricted mobility and/or uncontrolled disease were identified as a key population where CHVs could provide home-based blood glucose and blood pressure measurement and targeted health education to provide more precise monitoring. <h3>Conclusions</h3> CHV programmes were cited as a key strategy to implement secondary prevention of morbidity and mortality among Syrian refugees, particularly those at high risk of decompensation.
Sharing Research Data
Authors: Ronald M. Andersen
Journal: JAMA (1987)

To share or not to share behavioral and social science research data—why should<i>JAMA</i>review a book addressing this issue? After deliberation, it seems worthwhile for most physicians to consider the points raised in<i>Sharing Research Data</i>because, "some data-sharing problems in the biomedical sciences... are similar to those in the social sciences: for example, problems associated with large-scale, controlled clinical trials closely resemble those associated with large-scale social surveys" (p 6). Furthermore, various problems raised will strike responsive cords depending on your major occupational activities. The clinician will empathize with the need to protect respondent-patient confidentiality. However, as a consumer of research, the clinician also stands to benefit from secondary research suggesting improved patient diagnosis and treatment. The researcher will understand the proprietary interests that the primary investigator has in the painstakingly collected data, and will also understand the appetite of the secondary investigator for using data collected by
HIGH-DOSE PLASMID-MEDIATED VASCULAR ENDOTHELIAL GROWTH FACTOR GENE TRANSFER IN PATIENTS WITH SEVERE CORONARY ARTERY DISEASE (GENESIS-I). SIX MONTHS RESULTS OF THE FIRST PHASE I LATIN AMERICAN TRIAL OF GENE THERAPY IN MYOCARDIAL ISCHEMIA
Authors: Liliana Ethel Favaloro, Mirta Diez, Oscar Mendiz, Leon Valdivieso, Andres Bercovich, Marcelo E. Criscuolo, Gustavo Vera Janavel, Alberto J. Crottogini
Journal: Journal of the American College of Cardiology (2010)