tbuckley/cabot-search huggingface dataset:
Long-Term Anticoagulant Therapy
Authors: Donald H. Mosley, Irwin J. Schatz, Gerald M. Breneman, John W. Keyes
Journal: JAMA (1963)

As experience in the use of anticoagulant drugs accumulates, analysis of the incidence of complications is necessary to assess the risk of outpatient therapy. The records of all outpatients at the Henry Ford Hospital treated with long-term anticoagulants from August, 1961, to August, 1962, were reviewed. Complications and control were studied for this period in all 978 patients, though 808 had received treatment for over one year. All patients were treated for at least three months. Fifteen patients (1.5%) experienced major hemorrhage, and 218 patients (22%) reported minor bleeding not necessitating hospital care. No significant correlation was observed between prothrombin level and major complications. Fifty-five deaths occurred during the period of study, and in four of these patients, anticoagulants may have been a contributing factor. The findings clearly indicate that with adequate precautions, long-term outpatient anticoagulant therapy is practical and safe.
Lactose absorption, milk consumption, and fasting blood glucose concentrations in women with idiopathic osteoporosis.
Authors: G Finkenstedt, F Skrabal, R W Gasser, H Braunsteiner
Journal: BMJ (1986)

Lactose tolerance tests were performed in 33 women with osteoporosis and 33 control women matched for age. A questionnaire was used to elicit any history of milk intolerance and the subjects9 daily intake of calcium derived from milk and dairy products. Eleven patients and four controls gave a history of milk intolerance (p less than 0.01); 13 patients had lactose malabsorption compared with four controls (p less than 0.01). The daily intake of calcium derived from milk was significantly lower in patients (125 (SEM 20) mg v 252 (43) mg; p less than 0.05). Curves of blood glucose concentrations during the lactose tolerance test in subjects with lactose malabsorption were significantly flatter in patients than controls (p less than 0.05). The fasting blood glucose concentration was higher (5.44 (0.17) mmol/l (98 (3) mg/100 ml) in the patients than the controls (4.88 (0.11) mmol/l (88 (2) mg/100 ml); p less than 0.05), although body weight was significantly lower (61.6 (2.2) kg v 66.3 (1.6) kg; p less than 0.05). Absorption of lactose is significantly impaired in women with "idiopathic" osteoporosis; this combined with low consumption of milk and a subclinical disorder of glucose metabolism may be a major factor in the development of idiopathic osteoporosis in women.
TCT-778 When Is Aortic Regurgitation Important In Transcatheter Aortic Valve Implantation
Authors: Sanjeevan Pasupati, David W. Muller, Tony Walton, Darren L. Walters, Stephen G. Worthley, John A. Ormiston, Robert J. Whitbourn, Gerald Yong, Ian T. Meredith
Journal: Journal of the American College of Cardiology (2013)
Blood Lead and Blood Pressure
Authors: Walter C. Hulon
Journal: JAMA (1985)

To the Editor.—  The recent article on blood lead and blood pressure1is written so unclearly that it is difficult to understand precisely how the authors meant to use the data.  Immediately obvious to the reader is the fact that the Figure plots blood lead and diastolic blood pressure for subjects aged 12 to 74 years, while the results of the multiple regression analyses in Table 1 are only for subjects aged 21 to 74 years. The text in one section discusses the Figure and later refers to Tables 1 through 3; this inconsistency in the discussion of the data set makes it difficult to follow the article. Nevertheless, the Figure makes it appear that virtually everyone is normotensive, so there are apparently no adverse implications for cardiovascular health based on the essentially linear relationship between blood lead and blood pressure. Seemingly, the behavior of the data at extremely high
THE EXTRACTION OF THE CELL CONTENT OF MICRO-ORGANISMS BY PERCUSSION OF THE FROZEN CELLS
Authors: J. M. Johlin, Roy C. Avery
Journal: The Journal of Experimental Medicine (1930)

A method is described for rapidly obtaining fresh extracts of microorganisms by percussion of the frozen cells. Filtrates giving the biuret reaction and yielding heavy precipitates upon the addition of acetic acid were obtained from the washed cells of cultures of yeast, hemolytic streptococcus, pneumococcus, B. coli, B. xerosis, B. dyphtheriae and the bacillus of bovine tuberculosis.
Disasters: Hospital Planning—A Manual for Doctors, Nurses and Administrators
Authors: Larry N. Marcum
Journal: JAMA (1980)

This reviewer approached<i>Disasters: Hospital Planning</i>with more than an average amount of optimism, as the task of revising the prehospital portion of his own community disaster plan lay ahead. The book is divided into two parts. The first describes the general considerations and content of disaster planning and has some good ideas; the second represents the working disaster manual of an obviously large, well-staffed hospital and appears to be overly detailed and confusing, especially when one considers the general disorder that is characteristic of any unforeseen emergency worthy of being dubbed "disaster." The author appears to have more than a reading knowledge of his subject. However, the entire planning process as projected seems useful only to large medical centers in urban areas. The text details a plan for such a center while failing to address the limitations of the more commonplace community hospital. The author might have made a
Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients
Authors: Paula M. Chilton, Francine Rezzoug, Mariusz Z. Ratajczak, Isabelle Fugier-Vivier, Janina Ratajczak, Magda Kucia, Yiming Huang, Michael K. Tanner, Suzanne T. Ildstad
Journal: Blood (2004)
Pluripotent Stem Cell miRNAs and Metastasis in Invasive Breast Cancer
Authors: Stefano Volinia, Gerard Nuovo, Alessandra Drusco, Stefan Costinean, Ramzey Abujarour, Caroline Desponts, Michela Garofalo, Raffaele Baffa, Rami Aeqilan, Kati Maharry, Maria Elena Sana Ramiro Garzon, Gianpiero Di Leva, Pierluigi Gasparini, Paola Dama, Jlenia Marchesini, Marco Galasso, Marco Manfrini, Carlotta Zerbinati, Fabio Corrà, Timothy Wise, Sylwia E. Wojcik, Maurizio Previati, Flavia Pichiorri, Nicola Zanesi, Hansjuerg Alder, Jeff Palatini, Kay F. Huebner, Charles L. Shapiro, Massimo Negrini, Andrea Vecchione, Anne L. Rosenberg, Carlo M. Croce
Journal: JNCI Journal of the National Cancer Institute (2014)

The purpose of this study is to determine whether microRNA for pluripotent stem cells are also expressed in breast cancer and are associated with metastasis and outcome. We studied global microRNA profiles during differentiation of human embryonic stem cells (n =26) and in breast cancer patients (n = 33) and human cell lines (n = 35). Using in situ hybridization, we then investigated MIR302 expression in 318 untreated breast cancer patients (test cohort, n = 22 and validation cohort, n = 296). In parallel, using next-generation sequencing data from breast cancer patients (n = 684), we assessed microRNA association with stem cell markers. All statistical tests were two-sided. In healthy tissues, the MIR302 (high)/MIR203 (low) asymmetry was exclusive for pluripotent stem cells. MIR302 was expressed in a small population of cancer cells within invasive ductal carcinoma, but not in normal breast (P < .001). Furthermore, MIR302 was expressed in the tumor cells together with stem cell markers, such as CD44 and BMI1. Conversely, MIR203 expression in 684 breast tumors negatively correlated with CD44 (Spearman correlation, Rho = -0.08, P = .04) and BMI1 (Rho = -0.11, P = .004), but positively correlated with differentiation marker CD24 (Rho = 0.15, P < .001). Primary tumors with lymph node metastasis had cancer cells showing scattered expression of MIR302 and widespread repression of MIR203. Finally, overall survival was statistically significantly shorter in patients with MIR302-positive cancer cells (P = .03). In healthy tissues the MIR302(high)/MIR203(low) asymmetry was characteristic of embryonic and induced pluripotency. In invasive ductal carcinoma, the MIR302/MIR203 asymmetry was associated with stem cell markers, metastasis, and shorter survival.
Partial Albinism
Authors: Bruce Campbell
Journal: JAMA (1962)

Partial albinism is a rare congenital defect of the skin, in which absence of melanin pigment in various areas is found at birth and is permanent. In contrast to total albinism, it is a genetic dominant, and never involves any organ except the skin. Six members of a Mexican family who have varying degrees of partial albinism have been seen. They all showed the most common feature of the condition, a depigmented strip of hair arising in the frontal area and known as a "white forelock," in addition to other patches of depigmentation. Histologic studies that employed special staining techniques were unable to demonstrate any melanin formation in the white spots. Therapeutic trial, using one of the oral psoralen derivatives, failed to stimulate melanogenesis.
Understanding Economic and Other Burdens of Terminal Illness: The Experience of Patients and Their Caregivers
Authors: Ezekiel J. Emanuel, Diane L. Fairclough, Julia Slutsman, Linda L. Emanuel
Journal: Annals of Internal Medicine (2000)

Background: Terminal illness imposes substantial burdens—economic and otherwise—on patients and caregivers. The cause of these burdens is not understood. Objective: To determine the mechanism for economic and noneconomic burdens of terminal illness and to identify potential ameliorating interventions. Design: In-person interviews of terminally ill patients and their caregivers. Setting: Six randomly selected U.S. sites: Worcester, Massachusetts; St. Louis, Missouri; Tucson, Arizona; Birmingham, Alabama; Brooklyn, New York; and Mesa County, Colorado. Participants: 988 terminally ill patients and 893 caregivers. Measurements: Needs for transportation, nursing care, homemaking, and personal care; subjective perception of economic burden; expenditure of more than 10% of household income on health care costs; caregiver depression and sense of interference with his or her life; and patient consideration of euthanasia or physician-assisted suicide. Results: Of all patients, 34.7% had substantial care needs. Patients who had substantial care needs were more likely to report that they had a subjective sense of economic burden (44.9% compared with 35.3%; difference, 9.6 percentage points [95% CI, 3.1 to 16.1]; P = 0.005); that 10% of their household income was spent on health care (28.0% compared with 17.0%; difference, 11.0 percentage points [CI, 4.8 to 17.1]; P ≤ 0.001); and that they or their families had to take out a loan or mortgage, spend their savings, or obtain an additional job (16.3% compared with 10.2%; difference, 6.1 percentage points [CI, 1.4 to 10.6]; P = 0.004). Patients with substantial care needs were more likely to consider euthanasia or physician-assisted suicide (P = 0.001). Caregivers of these patients were more likely to have depressive symptoms (31.4% compared with 24.8%; difference, 6.6 percentage points [CI, 0.4 to 12.8]; P = 0.01) and to report that caring for the patients interfered with their lives (35.6% compared with 24.3%; difference, 11.3 percentage points [CI, 5.0 to 17.7]; P = 0.001). Caregivers of patients whose physicians listened to patients' and caregivers' needs had fewer burdens. Conclusions: Substantial care needs are an important cause of the economic and other burdens imposed by terminal illness. Through empathy, physicians may be able to ameliorate some of these burdens.
Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3
Authors: Michael H. Tomasson, Ifor R. Williams, Shaoguang Li, Jeffrey Kutok, Danielle Cain, Silke Gillessen, Glenn Dranoff, Richard A. Van Etten, D. Gary Gilliland
Journal: Blood (2001)
Quality of life of parents of children on home parenteral nutrition
Authors: C WONG
Journal: Gut (2000)

Editor,—Jeppesen and colleagues ( Gut 1999; 44 :844–852) used the non-disease specific sickness impact profile (SIP) and the disease specific inflammatory bowel disease questionnaire (IBDQ) to assess the quality of life of 49 patients receiving home parenteral nutrition (HPN). They found a significant reduction in the quality of life of these patients compared with patients with anatomical or functional short bowel not receiving HPN.

We showed …
Abortion due to infection with Chlamydia psittaci in a sheep farmer's wife.
Authors: F W Johnson, B A Matheson, H Williams, A G Laing, V Jandial, R Davidson-Lamb, G J Halliday, D Hobson, S Y Wong, K M Hadley
Journal: BMJ (1985)

A farmer9s wife who had helped with lambing aborted spontaneously in March after a short febrile illness in the 28th week of her pregnancy. She developed disseminated intravascular coagulation post partum with acute renal failure and pulmonary oedema. Recovery was complete after two weeks of hospital care. A strain of Chlamydia psittaci, probably of ovine origin, was isolated from the placenta and fetus. The patient9s serum showed rising titres of antibody against chlamydia group antigen; the placental and fetal isolates; and a known ovine abortion, but not a known avian, strain of C psittaci. IgG against both ovine abortion and enteric strains of C psittaci was detected, but IgM against only an abortion strain was detected. Histological examination showed pronounced intervillus placentitis with chlamydial inclusions in the trophoblast but no evidence of fetal infection or amnionitis. Laboratory evidence of chlamydial infection was found in an aborting ewe on the farm in January and in remaining sheep and lambs in July. Doctors should recognise the possible risk to pregnant women in rural areas where chlamydial infections in farm animals are widespread.
Striped Nails and Kidney Transplantation
Authors: IRWIN M. BRAVERMAN
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 August 1978Striped Nails and Kidney TransplantationIRWIN M. BRAVERMAN, M.D.IRWIN M. BRAVERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-2-286 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The paper by Morton Linder in the June issue, "Striped Nails After Kidney Transplant" (Ann Intern Med88:809, 1978), includes a statement that striped nails or transverse striae (leukonychia) have been associated with renal disease only when accompanied by hypoalbuminemia. The striped nails associated with hypoalbuminemia of renal disease are not the same as those described in his interesting report. The stripes associated with hypoalbuminemia do not move out as the nail plate grows but, rather, remain stationary. The stripes represent an unknown type of abnormality in thenail beditself. The stripes that Dr. Linder describes... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Yale University School of Medicine New Haven, CT 06510 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTransverse striate leukonychia associated with acute rejection of renal allograftDermatologic Disorders Associated with Chronic Renal FailureCutaneous Associations of Chronic Renal Failure and Dialysis 1 August 1978Volume 89, Issue 2Page: 286-287KeywordsRenal diseasesRenal transplantation Issue Published: 1 August 1978 PDF downloadLoading ...
Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures
Authors: Junji Fukuda, Ali Khademhosseini, Yoon Yeo, Xiaoyu Yang, Judy Yeh, George Eng, James Blumling, Chi-Fong Wang, Daniel S. Kohane, Robert Langer
Journal: Biomaterials (2006)
A therapeutic application of the experience sampling method in the treatment of depression: a randomized controlled trial
Authors: Ingrid Kramer, Claudia J.P. Simons, Jessica A. Hartmann, Claudia Menne-Lothmann, Wolfgang Viechtbauer, Frenk Peeters, Koen Schruers, Alex L. van Bemmel, Inez Myin-Germeys, Philippe Delespaul, Jim van Os, Marieke Wichers
Journal: World Psychiatry (2014)

In depression, the ability to experience daily life positive affect predicts recovery and reduces relapse rates. Interventions based on the experience sampling method (ESM-I) are ideally suited to provide insight in personal, contextualized patterns of positive affect. The aim of this study was to examine whether add-on ESM-derived feedback on personalized patterns of positive affect is feasible and useful to patients, and results in a reduction of depressive symptomatology. Depressed outpatients (n=102) receiving pharmacological treatment participated in a randomized controlled trial with three arms: an experimental group receiving add-on ESM-derived feedback, a pseudo-experimental group participating in ESM but receiving no feedback, and a control group. The experimental group participated in an ESM procedure (three days per week over a 6-week period) using a palmtop. This group received weekly standardized feedback on personalized patterns of positive affect. Hamilton Depression Rating Scale – 17 (HDRS) and Inventory of Depressive Symptoms (IDS) scores were obtained before and after the intervention. During a 6-month follow-up period, five HDRS and IDS assessments were completed. Add-on ESM-derived feedback resulted in a significant and clinically relevant stronger decrease in HDRS score relative to the control group (p<0.01; −5.5 point reduction in HDRS at 6 months). Compared to the pseudo-experimental group, a clinically relevant decrease in HDRS score was apparent at 6 months (B=−3.6, p=0.053). Self-reported depressive complaints (IDS) yielded the same pattern over time. The use of ESM-I was deemed acceptable and the provided feedback easy to understand. Patients attempted to apply suggestions from ESM-derived feedback to daily life. These data suggest that the efficacy of traditional passive pharmacological approach to treatment of major depression can be enhanced by using person-tailored daily life information regarding positive affect.
Somatostatin-Receptor Imaging for the Detection of Tumors
Authors: Yogesh C. Patel
Journal: New England Journal of Medicine (1990)

The neuropeptide somatostatin was discovered in Guillemin's laboratory at the Salk Institute 18 years ago.1 From a relatively humble beginning as a hypothalamic growth hormone inhibitor, it has emerged as a major regulatory peptide with an extraordinary range of biologic actions.2 Cells containing somatostatin are typically neurons or endocrine-like cells, found in their highest density in the brain, among peripheral neurons, in the endocrine pancreas and in the gastrointestinal tract, and in small numbers in the thyroid, adrenals, submandibular gland, urinary tract, and placenta. These cells produce various mixtures of the two biologically active somatostatins — somatostatin-14, the form originally . . .
Nonmyeloablative Allogeneic Hematopoietic Cell Transplantation in Relapsed, Refractory, and Transformed Indolent Non-Hodgkin's Lymphoma
Authors: Andrew R. Rezvani, Barry Storer, Michael Maris, Mohamed L. Sorror, Edward Agura, Richard T. Maziarz, James C. Wade, Thomas Chauncey, Stephen J. Forman, Thoralf Lange, Judith Shizuru, Amelia Langston, Michael A. Pulsipher, Brenda M. Sandmaier, Rainer Storb, David G. Maloney
Journal: Journal of Clinical Oncology (2007)

Few effective treatment options exist for chemotherapy-refractory indolent or transformed non-Hodgkin's lymphoma (NHL). We examined the outcome of nonmyeloablative allogeneic hematopoietic cell transplantation (HCT) in this setting.Sixty-two patients with indolent or transformed NHL were treated with allogeneic HCT from related (n = 34) or unrelated (n = 28) donors after conditioning with 2 Gy of total-body irradiation with or without fludarabine. Nine unrelated donors were mismatched for >/= one HLA antigen. Sixteen patients had histologic transformation before HCT. Twenty patients (32%) had progressive disease after previous high-dose therapy with autologous HCT. Median age was 54 years, and patients had received a median of six lines of treatment before HCT. Median follow-up time after HCT was 36.6 months.At 3 years, the estimated overall survival (OS) and progression-free survival (PFS) rates were 52% and 43%, respectively, for patients with indolent disease, and 18% and 21%, respectively, for patients with transformed disease. Patients with indolent disease and related donors (n = 26) had 3-year estimated OS and PFS rates of 67% and 54%, respectively. The incidences of grade 2 to 4 acute graft-versus-host disease (GVHD), grade 3 and 4 acute GVHD, and extensive chronic GVHD were 63%, 18%, and 47%, respectively. Among survivors, the median Karnofsky performance status at last follow-up was 85%.Nonmyeloablative allogeneic HCT can produce durable disease-free survival in patients with relapsed or refractory indolent NHL, even in this relatively elderly and heavily pretreated cohort. Outcomes were particularly good in patients with untransformed disease and related donors, whereas patients with transformed disease did poorly. Long-term survivors reported good overall functional status.
Intravenous Quinidine for the Treatment of Severe falciparum Malaria
Authors: Rodney E. Phillips, David A. Warrell, Nicholas J. White, Sornchai Looareesuwan, Juntra Karbwang
Journal: New England Journal of Medicine (1985)

Quinidine has proved more effective than quinine against chloroquine-resistant Plasmodium falciparum both in vitro and in patients with uncomplicated disease. To examine the effectiveness and pharmacokinetics of quinidine for this use, we treated 14 patients who had severe falciparum malaria with intravenous quinidine gluconate; a loading dose of 15 mg of the base per kilogram of body weight was followed by 7.5 mg per kilogram every eight hours. Two of the five patients with cerebral malaria died, but parasitemia was eliminated in the 12 survivors. Two patients had recurrent parasitemia on Days 25 and 28. Times required for parasite clearance and elimination of fever (49.4 +/- 17.8 and 69.5 +/- 18.7 hours, respectively) were comparable to those in earlier studies with a loading dose of quinine. Quinidine appears to have a larger volume of distribution than quinine. The elimination half-life was 12.8 hours, the volume of distribution was 1.68 liters per kilogram, total clearance was 1.75 ml per kilogram per minute, and urinary clearance was 0.62 ml per kilogram per minute. Electrocardiographic changes were common but there were no dysrhythmias. In two patients, blood pressure fell during the initial infusion of quinidine. Quinidine gluconate is more widely available than quinine in many countries, and our findings show that it is effective in severe falciparum malaria.
Acute Infectious Epiglottitis in Adults
Authors: H. JOEL GORFINKEL
Journal: Annals of Internal Medicine (1969)

Epiglottitis is a rapidly progressing disease, often fatal if not recognized and treated promptly. Sore throat followed by dysphagia and rapidly progressive respiratory distress is the characteristic mode of presentation. On indirect mirror laryngoscopy the epiglottis is found to be hyperemic and edematous. Three cases in adults are added to the 37 already found in the literature. Haemophilus influenzae, type B, is the commonest infecting organism, with Staphylococcus, Pneumococcus, and Streptococcus also isolated from fewer numbers of cases. The primary element in treatment is the maintenance of an adequate airway, including tracheostomy when indicated. Prompt, aggressive antibiotic treatment is indicated after suitable cultures are obtained. On the basis of the potential causal agents we recommend initiating treatment with a combination of ampicillin and methicillin.