tbuckley/cabot-search huggingface dataset:
Closing the Chapter on Maharishi Ayur-Veda
Authors: Margaret T. Singer
Journal: JAMA (1992)

<h3>To the Editor.</h3> —When I read the Letter from New Delhi by Sharma et al<i>1</i>I surmised that<i>JAMA</i>had been duped into printing a seeming endorsement of a dubious healing cult, Transcendental Meditation (TM), and its recent front, Maharishi Ayur-Veda.<i>JAMA</i>is to be commended for exposing the chicanery and deceptions involved in the appearance of that letter.<sup>2</sup> For many years I have studied and written about various totalist groups, some of which are health quackery cults. I have followed the development of the TM group from its early stages as a nonprofessional psychotherapy to the various front groups it now has spawned. I have interviewed and provided psychotherapy for dozens of former TM members who have suffered major psychological disorders (severe dissociative disorders, posttraumatic stress disorders, panic disorders, etc) which appear to have evolved out of the practices they were taught to follow.<sup>3-5</sup> I want
Oral Health Knowledge, Attitude, and Practices and Sources of Information for Diabetic Patients in Lahore, Pakistan
Authors: Kamran Masood Mirza, Ayyaz Ali Khan, Munawar Manzoor Ali, Saima Chaudhry
Journal: Diabetes Care (2007)

Sustained hyperglycemia affects almost all tissues in the body (1), including those in the oral cavity (2). Oral complications of diabetes include xerostomia, opportunistic infections, greater accumulation of plaque, delayed wound healing, susceptibility to periodontal disease, oral paresthesia, and altered taste (2). Studies suggest a bidirectional adverse relationship between diabetes and periodontal disease; diabetes can aggravate periodontitis, and periodontitis can negatively affect control of diabetes (3,4). Therefore, preventive behaviors like brushing, flossing, and periodic dental visits, which have a positive correlation with better periodontal health (5), become paramount for diabetic patients (6). Oral hygiene behavior and seeking oral health care depend on a number of factors. Patients comply better with oral health care regimens when informed and positively reinforced. Lack of information is among the reasons for nonadherence to oral hygiene practices. Further, oral health attitudes and beliefs are significant for oral health behavior (7). A higher likelihood of seeking preventive dental care is found to be associated with dental knowledge (8). The motives prompting people to seek preventive dental care include the beliefs that one is susceptible to dental disease, that dental problems are serious, and that dental treatment is beneficial. Those who believe that they are highly susceptible to dental disease make …
Challenging diagnostic and therapeutic modalities for leiomyosarcoma of inferior vena cava
Authors: Aikaterini Mastoraki, George Leotsakos, Sotiria Mastoraki, Ioannis S. Papanikolaou, Nikolaos Danias, Vasilios Smyrniotis, Nikolaos Arkadopoulos
Journal: International Journal of Surgery (2014)
Mortality from coronary heart disease in the British army compared with the civil population
Authors: M. Newman
Journal: BMJ (1981)

prevalence figures, from well populations and hospital clinics, which in turn are the result of self-selection, referral patterns, and the age composition of the screened population.The data emphasise that, with a trend towards less selection of women for screening, the pre- dictive power of a positive diaphanoscopic test would be lower and that for a negative test higher than in their series.One case appears to be missing from their results but it does not materially influence the outcome.
Comparison of a quantitative PCR method with FISH for the assessment of the four aneuploidies commonly evaluated in CLL patients
Authors: C Bastard, G Raux, C Fruchart, F Parmentier, D Vaur, D Penther, X Troussard, D Nagib, S Lepretre, M Tosi, T Frebourg, H Tilly
Journal: Leukemia (2007)
Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2 receptor
Authors: C VANCHERI, E GILI, M FAILLA, C MASTRUZZO, E SALINARO, D LOFURNO, M PISTORIO, C LAROSA, M CARUSO, N CRIMI
Journal: Journal of Allergy and Clinical Immunology (2005)
Isolation and Quantitation of the Platelet Membrane Glycoprotein Deficient in Thrombasthenia Using a Monoclonal Hybridoma Antibody
Authors: Rodger P. McEver, Nancy Lewis Baenziger, Philip W. Majerus
Journal: Journal of Clinical Investigation (1980)

We used the hybridoma technique to characterize further the platelet glycoprotein abnormality in Glanzmann's thrombasthenia. Spleen cells from Balb/c mice immunized with human platelets were fused to mouse myeloma cell line Sp2/0-Ag14. Hybridoma lines producing a variety of antiplatelet antibodies were isolated by hypoxanthine-aminopterin-thymidine selection and cloned, and purified monoclonal IgG from six lines was prepared. One of these lines, 8aB5-9, produced an antibody, Tab, that binds to a protein on normal but not thrombasthenic platelets. We isolated this protein from Triton X-100 solubilized normal platelet membranes by affinity chromatography on Tab-Sepharose. As determined by SDS polyacrylamide gel electrophoresis, the isolated protein is a complex of glycoproteins IIb and IIIa, because the two subunits comigrate with glycoproteins IIb and IIIa of whole platelets and show identical changes in mobility after disulfide bond reduction. We prepared 125I-Tab to determine the number of glycoprotein IIb-IIIa complexes on normal and thrombasthenic platelets by a direct binding assay. Platelets from 17 normal donors bound 39,000±4,600 (SD) Tab molecules/platelet. Platelets from four patients with thrombasthenia lacked Tab binding sites (<5%). Five obligate and four presumed heterozygotes for thrombasthenia bound 24,500±5,800 Tab molecules/platelet. The platelet alloantigen, PlAl, is not that recognized by Tab, because platelets from three PlAl-negative subjects bound Tab normally. Studies with the Tab antibody have (a) enabled quantitation of the number of glycoprotein IIb-IIIa complexes on normal platelet membranes, (b) demonstrated that thrombasthenic homozygotes lack and heterozygotes have a partial deficiency of this complex, and (c) made possible the isolation of this membrane protein which may be required for normal platelet aggregation and clot retraction.
Life expectancy differs by 30 years between richest and poorest countries, report shows
Authors: J. Zarocostas
Journal: BMJ (2009)

OBJECTIVE: To estimate the effectiveness of influenza vaccine in preventing hospital admission for pneumonia in non-institutionalised elderly people. DESIGN: This was a case-control study. SETTING: All three public hospitals in the Castellón area of Spain. PARTICIPANTS: Cases were people aged 65 or more not living in an institution who were admitted to hospital for pneumonia between November 15, 1994 and March 31, 1995. Each case was matched with two sex matched control subjects aged 65 years or older admitted to hospital in the same week for acute abdominal surgical conditions or trauma. The sampling of incident cases was consecutive. Eighty three cases and 166 controls were identified and included in the study. MEASUREMENTS: Trained interviewers completed a questionnaire for each subject on the vaccination status, smoking habits, previous diseases, health care use, social contacts, family background, the vaccination status of the family carer, home characteristics, and socioeconomic status. RESULTS: The adjusted odds ratio of the influenza vaccination preventing admission to hospital for pneumonia was 0.21 (95% confidence interval 0.09, 0.55). The variables which best explained the risk of being a case were age, intensity of social contacts, health care use, previous diseases, and the existence of a vaccinated family carer. CONCLUSIONS: Influenza vaccination reduced significantly hospital admissions for pneumonia in non-institutionalised elderly people.
Letter: Erythema infectiosum (fifth disease).
Authors: F Brandrup, O Larsen
Journal: BMJ (1976)

hours after dosing, by 7-16",, 16 hours after dosing, and by 8-13",, 24 hours after dosing.Thus once-daily therapy with sotalol has a 24-hour effect in reducing blood pressure.(2) The dose of sotalol eventually required was related to the initial diastolic blood pressure.(3) In at least one patient there appeared to be a correlation between standing diastolic pressure, heart rate, and sotalol dosage.Detailed analysis of these data will be published in due course.
Immunologic Considerations for Therapeutic Strategies Utilizing Allogeneic Hepatocytes: Hepatocyte-Expressed Membrane-Bound Major Histocompatibility Complex Class I Antigen Sensitizes While Soluble Antigen Suppresses the Immune Response in Rats
Authors: Marcus N. Scherer, Christian Graeb, Stefan Tange, Chrissie Dyson, Karl-Walter Jauch, Edward K. Geissler
Journal: Hepatology (2000)

Understanding the immunologic effects of hepatocytes is critical because of the potential to use these cells for bioartificial livers, as a vehicle for gene transfer, and as a means to induce donor–specific immunosuppression in organ transplantation. However, this understanding is complicated by the fact that hepatocytes express membrane–bound and soluble forms of major histocompatibility complex (MHC) class I antigen, each with the potential to induce different immune responses. In the present study we first determined the immunologic effect of normal donor–derived hepatocytes in a rat heart transplant model. We then used ex vivo hepatocyte gene transfer to examine the immunologic effects of different forms of hepatocyte–expressed MHC class I antigen. Results showed that intrasplenic injection of purified, donor–strain-specific hepatocytes into recipients primes alloimmunity, as evidenced by acceleration of heart allograft rejection. Interestingly, injection of autologous hepatocytes transfected ex vivo with DNA encoding only membrane–bound donor MHC class I antigen (RT1.A a ) also accelerated allograft rejection. However, hepatocytes transfected to express only secreted donor MHC antigen prolonged transplant survival. Limiting–dilution analysis of lymphocytes from animals treated with hepatocytes producing only secreted alloantigen showed an antigen–specific reduction in cytotoxic T lymphocyte (CTL) and helper T lymphocyte (HTL) precursors. Further analysis of CTL populations by flow cytometry revealed a relatively high percentage of nonviable cells, implying that soluble antigen promotes allospecific CTL death. In summary, this study suggests that hepatocyte–expressed MHC class I molecules have opposing immunologic effects, with the membrane–bound antigen inducing immunologic sensitization, and the soluble antigen promoting donor–specific immunosuppression.
Serum growth hormone-binding protein, insulin-like growth factor-I, and growth hormone in patients with liver cirrhosis
Authors: Naoki Hattori, Hiroyuki Kurahachi, Katsuji Ikekubo, Takashi Ishihara, Kunisaburo Moridera, Megumu Hino, Yasuhiko Saiki, Hiroo Imura
Journal: Metabolism (1992)
Textbook of Gastroenterology and Nutrition in Infancy, vol 1: Gastrointestinal Development and Perinatal Nutrition; vol 2: Gastrointestinal Diseases and Nutritional Inadequacies
Authors: Barbara S. Kirschner
Journal: JAMA (1982)

It is a rare pleasure to read a text that presents so many of the important aspects of pediatric gastroenterology in infancy with the depth and clarity of this work. This two-volume comprehensive textbook was written by persons who have made major contributions to the field. Despite the multiauthored format, there is consistency of presentation and style, which results in a highly readable and informative work. The first volume,<i>Gastrointestinal Development and Perinatal Nutrition</i>, contains 11 sections, each having a short preview of the information to be discussed. Included are chapters devoted to "Intrauterine Nutrition, Growth, and Development"; "Ontogeny of the Gastrointestinal Tract"; "Development of Immunologic and Bacteriologic Properties of the Gastrointestinal Tract"; "Carbohydrates in Infant Nutrition"; and "Fats in Infant Nutrition." The content throughout is richly supported by studies in experimental animals and human infants. The goal is always to explain gastrointestinal physiology based on the most current knowledge
125. Enhancement of Virus Mediated Gene Transfer by Polycationic Compounds
Authors: Saara Lehmusvaara, Eveliina Pasanen, Outi Rautsi, Tanja Hakkarainen, Marika Ruponen, Jarmo Wahlfors
Journal: Molecular Therapy (2006)

The enhancing effect of cell-permeable peptides and polycations to virus-mediated gene transfer was investigated by transducing different cell lines with virus-polycation complexes. In addition, blocking of intracellular polyamine production with defluoromethylornithine (DFMO) was used to intensify heparan sulfate proteoglycan (HSPG) transport from cell membrane to cytoplasm. With this approach we tested whether the accelerated HSPG transport could also improve the transport of virus-polycation or virus-peptide complex. Methods: We transduced lenti- and adenoviruses to five different human cancer cell lines and a monkey fibroblast cell line (COS-7), a rat glioma cell line (9L) and 3 different variants of Chinese hamster ovary cell lines: parental (CHO), HS-deficient (pgsD-677) and glycosaminoglycan (GAG) deficient (pgsB-618). To enhance transduction, we incubated viruses with polybasic peptides from HIV-1 (TAT) and Drosophila (Antennapedia), or added 8 mg/ml polybrene or 5 mg/ml protamine to transduction medium. To block the intracellular polyamine production, we treated cells with 1 mM DFMO two days before transduction. Gene transfer rates were determined by analyzing the cells 2-5 days post-transduction with flow cytometry. Results: All cationic compounds, including cell-permeable peptides enhanced transduction in most of the cell lines. In every cell line, Antennapedia-peptide was more efficient than TAT-peptide. However, protamine was approximately as effective as cell-permeable peptides and polybrene appeared to be the best in every cell line. DFMO treatment did not give any extra boost for lentiviral transduction with or without the polycationic compounds. When DFMO treatment was combined with adenovirus-polycation complexes, significantly elevated transduction efficiency was achieved. In HS- and GAG-deficient cell lines adenovirus transduction with polycations was remarkably lower than in the parental cell line. DFMO treatment, however, enhanced viral transduction also in these cells lines. Conclusion: Our results show that both adeno- and lentiviral transduction can be improved in vitro with polycationic compounds, including cell-permeable peptides. Furthermore, DFMO treatment can improve the transduction rate when adenovirus is conjugated with polycationic compounds. These results indicate that the intensified transport of extracellular polyamines can enhance viral transduction, when viruses are covered with polycationic compounds. Furthermore, in HS- and GAG-deficient cell lines adenovirus transduction was significantly reduced, suggesting that virus-polycation-complexes are utilizing glygosaminoglycans for their attachment to cell surfaces.
TREATMENT OF HOOPING-COUGH
Authors: J. G. Davey
Journal: BMJ (1854)

ewAt) u i d inuban wus o Motri.I.dim i hos in Twk it is incude te aeoouut is for t psamewat uammga A preparat cnsis ef, solution of l3ytC her in iectibd spirt, W ikodu"d into the EdinburghwaP7a a a of 1735,unde thX nme of spiritua Qse duk.It does not appear to hum baen much ued.In 1804, Gehler published a dis- -mlation on tbe subject.*It was soon omitted from the Edinburgh PAariacopana, andat the t time is not i l
Use and Abuse of Appetite-Suppressant Drugs in the Treatment of Obesity
Authors: George A. Bray
Journal: Annals of Internal Medicine (1993)

Most of the available appetite-suppressant drugs act on noradrenergic and possibly dopaminergic receptors to produce satiety. A smaller number increase excess neuronal serotonin levels by blocking serotonin reuptake or by increasing its release. All these drugs produce significantly greater weight loss than does placebo in most studies. Abuse is a problem with amphetamine, methamphetamine, and benzphetamine, whereas other drugs have minimal or no potential for abuse. Weight loss can be sustained for up to 36 months. Net weight loss, compared with placebo, ranges from 2 to 10 kg, and weight regain after terminating drug treatment proves that drugs do not work when not taken. The stigma of obesity, the public opprobrium toward obese persons, and regulatory rigidity have led to unjustified distrust in the potential of drug treatment for obesity.
Vancomycin-induced linear IgA disease with autoantibodies to BP180 and LAD285.
Authors: R.A. Palmer, G. Ogg, J. Allen, A. Banerjee, K.S. Ryatt, R. Ratnavel, F. Wojnarowska
Journal: British Journal of Dermatology (2001)

Linear IgA disease (LAD) is an acquired autoimmune subepidermal bullous disease characterized by the linear deposition of IgA at the basement membrane zone. A minority of cases are induced by drugs, of which the most frequently implicated is vancomycin. The target antigens in idiopathic LAD are heterogeneous, but have not previously been reported in vancomycin-induced LAD. We report three cases, and in two of these we investigated the target antigens. In both we identified IgA antibodies to LAD285 and IgA and IgG antibodies (dual response) to BP180.
Saphenous vein graft patency 1 year after coronary artery bypass surgery and effects of antiplatelet therapy. Results of a Veterans Administration Cooperative Study.
Authors: S Goldman, J Copeland, T Moritz, W Henderson, K Zadina, T Ovitt, J Doherty, R Read, E Chesler, Y Sako
Journal: Circulation (1989)

To determine whether antiplatelet therapies improve saphenous vein graft patency after coronary artery bypass grafting, we compared 1) aspirin (325 mg once daily), 2) aspirin (325 mg three times daily), 3) aspirin and dipyridamole (325 mg and 75 mg, respectively, three times daily), 4) sulfinpyrazone (267 mg three times daily), and 5) placebo (three times daily). Therapy with dipyridamole and sulfinpyrazone was started 48 hours before bypass graft surgery, and aspirin treatment was begun 12 hours before surgery as a single 325-mg dose. Postoperative treatment was started 6 hours after surgery and continued for 1 year. Graft patency data were obtained early (median, 9 days) and late (median, 367 days) after surgery. The early graft occlusion rate was decreased with all aspirin treatment regimens compared with that of the placebo regimen. At 1 year, in 406 patients with 1,315 grafts, the graft occlusion rate in all of the aspirin groups combined was 15.8% compared with 22.6% for the placebo group (p = 0.029). The patients taking aspirin once daily had a lower occlusion rate (13.2%) compared with the patients receiving placebo (p = 0.050). At 1 year, in the vein grafts placed to vessels less than or equal to 2.0 mm in diameter (804 distal sites), the graft occlusion rate in all of the aspirin groups was 20.1% compared with 32.3% for the placebo group (p = 0.008). In the vein grafts placed to vessels greater than 2.0 mm in diameter (511 distal sites), there was no difference in the occlusion rates between aspirin and the placebo group at 1 year (8.7% vs. 9.0%, p = 0.918).(ABSTRACT TRUNCATED AT 250 WORDS)
PATHOLOGIC HISTOLOGY OF THE SHWARTZMAN PHENOMENON WITH INTERPRETATIVE COMMENTS
Authors: Howard T. Karsner, Alan Richards Moritz
Journal: The Journal of Experimental Medicine (1934)

The histological study of the reaction to injection of the preparatory factor of the Shwartzman phenomenon shows it to be an exudative inflammation, but furnishes no conclusive evidence as to whether or not the inflammation is conditioned by previous sensitization to substances contained in the bacterial filtrate. The histological study of the local reaction which follows the intravenous injection of reacting or provocative factor shows exudative inflammation which differs from that due to the preparatory factor principally in the increased general severity and marked damage to blood vessels. The increased severity of reaction which follows the intravenous injection is probably due to concentration of the injurious agent at the site of inflammation determined by the preparatory local injection. The exudative phenomena caused by the preparatory local injection are edema and infiltration of polymorphonuclear leucocytes and large mononuclear cells. Vascular injury is morphologically demonstrable in only a few of the sections, notably those from periarticular structures. The intravenous injection determines an increase in cellular infiltration, necrosis of exudate, phagocytosis of cell debris, destruction of vascular walls and hemorrhage. Healing is due to granulation, organization and cicatrization.
Mortality, morbidity, resource allocation, and planning
Authors: A. Harris
Journal: BMJ (1981)

Therapeutics Bulletins.7This recommendation was purely on the grounds that dextromoramide tablets are more convenient than morphine solution.However, morphine is now available in a 10 mg slow-release tablet formulation and therefore this point is no longer valid.Clinical experience in terminal care, both in Leeds and elsewhere,8-'0 has led us to conclude that dextromoramide is a less suitable analgesic than morphine, diamorphine, or phenazocine for the control of pain in terminal illness.
EARLY COMPLETE ATRIOVENTRICULAR BLOCK WITH FAST ATRIAL RATE STRONGLY PREDICTS IN-HOSPITAL ADVERSE CLINICAL OUTCOMES IN PATIENTS WITH REPERFUSED INFERIOR ACUTE MYOCARDIAL INFARCTION
Authors: Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi, Noriaki Iwahashi, Nobuhiko Maejima, Kengo Tsukahara, Eiichi Akiyama, Satoshi Umemura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2015)
Transcobalamin II in human seminal plasma.
Authors: R Carmel, G S Bernstein
Journal: Journal of Clinical Investigation (1984)

Study of cobalamin-binding proteins revealed seminal plasma to be the most concentrated site of transcobalamin II in man. The next richest normal fluid, blood, has approximately one-tenth its concentration. Normal seminal unsaturated cobalamin-binding capacity averaged 15,030 +/- 7,290 pg/ml, of which 11,550 +/- 6,660 pg/ml was transcobalamin II. Transcobalamin II levels were markedly diminished in subjects lacking seminal vesicles (1520-1660 pg/ml), but not after vasectomy. This suggests that seminal vesicles are the chief source of this protein in semen. R binder concentration was increased in postvasectomy subjects (9,970 +/- 4,900 pg/ml vs. 2,980 +/- 1,370 pg/ml in normals) and varied in other patients. The endogenous cobalamin content of semen was only 88-699 pg/ml, and was carried largely by R binder rather than by transcobalamin II. The function of the unusually large seminal transcobalamin II pool in reproduction is unknown, but seems unlikely to be related solely to cobalamin transport needs, at least within the male reproductive tract itself.
A complication of capillary glucose monitoring.
Authors: A Fiorini
Journal: BMJ (1986)

clotted within 30 minutes and had separated after overnight incubation.At pH 1 it solidified instantly, later to separate.In further testing to establish why this did not happen in vivo Osmolite-.asmixed with pepsin and adjusted to pH 1.The mixture became frothy, and solidification was considerably inhibited.A gastric aspirate from the patient was found to be pH 4.