A Steroid-Responsive Nephrotic Syndrome in a Patient with Human Immunodeficiency Virus (HIV) Infection
Authors: Richard G. Appel
Journal: Annals of Internal Medicine (1990)

Brief Reports1 December 1990A Steroid-Responsive Nephrotic Syndrome in a Patient with Human Immunodeficiency Virus (HIV) InfectionRichard G. Appel, MD, James Neill, MDRichard G. Appel, MD, James Neill, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-11-892 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with human immunodeficiency virus (HIV) seropositivity may present with various renal abnormalities, including minimal, focal, or diffuse glomerular mesangial proliferation (1-3). In addition, they may present with the "HIV-associated nephropathy" syndrome, which is characterized by a rapid progression to end-stage renal disease (4-7). We provide evidence that therapeutic intervention is appropriate in some settings.Case ReportA 37-year-old white man developed generalized lymphadenopathy in August 1988. A lymph node biopsy revealed benign reactive hyperplasia. Urinalysis revealed 4+ protein by dipstick. In September 1988, the patient was admitted with dyspnea associated with increasing fluid accumulation. He denied intravenous drug use,...References1. PardoAldanaColton VMR. Glomerular lesions in the acquired immunodeficiency syndrome. Ann Intern Med. 1984;101:429-34. LinkGoogle Scholar2. PardoMenesesOssa VRL. AIDS-related glomerulopathy: occurrence in specific risk groups. Kidney Int. 1987;31:1167-73. CrossrefMedlineGoogle Scholar3. StraussAbitbolZilleruelo JCG. Renal disease in children with the acquired immunodeficiency syndrome. N Engl J Med. 1989;321:625-30. CrossrefMedlineGoogle Scholar4. RaoFriedmanNicastri TEA. The types of renal disease in the acquired immunodeficiency syndrome. N Engl J Med. 1987;316:1062-8. CrossrefMedlineGoogle Scholar5. RaoFilipponeNicastri TEA. Associated focal and segmental glomerulosclerosis in the acquired immunodeficiency syndrome. N Engl J Med. 1984;310:669-73. CrossrefMedlineGoogle Scholar6. D'AgatiSuhCarboneChengAppel VJLJG. Pathology of HIV-associated nephropathy: a detailed morphologic and comparative study. Kidney Int. 1989;35:1358-70. CrossrefMedlineGoogle Scholar7. CarboneD'AgatiChengAppel LVJG. Course and prognosis of human immunodeficiency virus-associated nephropathy. Am J Med. 1989;87:389-95. CrossrefMedlineGoogle Scholar8. GlassockCohenDanovitchParsa RAGK. Human immunodeficiency virus (HIV) infection and the kidney. Ann Intern Med. 1990;112:35-49. LinkGoogle Scholar9. Bourgoignie J. Renal complications of human immunodeficiency virus type 1. Kidney Int. 1990;37:1571-84. CrossrefMedlineGoogle Scholar10. Babut-GayEchardKleinknechtMeyrier MMDA. Zidovudine and nephropathy with human immunodeficiency virus (HIV) infection. Ann Intern Med. 1989;111:856-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Bowman Gray School of Medicine, Winston-Salem, North Carolina; and the School of Medicine, East Carolina University, Greenville, North Carolina. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByKidney Disease in HIV InfectionMolecular Mechanisms of Injury in HIV-Associated NephropathyInfectious Diseases and the KidneyThrombotic Microangiopathy and Other Glomerular Disorders in the HIV-Infected PatientPharmacotherapy for Human Immunodeficiency Virus—Associated NephropathyRenal Manifestations of HIV InfectionThe HIV-associated renal diseases: Current insight into pathogenesis and treatmentHIV-Associated Nephropathy With Peripheral Edema, Arterial Hypertension, and HyperlipidemiaHIV-Associated Nephropathy: Case Study and Review of the LiteratureCohort study of the treatment of severe HIV-associated nephropathy with corticosteroidsSteroid-responsive nephrotic syndrome with minimal-change disease and IgA deposits in a HIV-infected patientRenal Complications of Intravenous Drug Abuse and Human Immunodeficiency Virus InfectionAIDS-associated membranous nephropathy with advanced renal failure: Response to prednisoneClinical response to prolonged corticosteroids in a patient with human immunodeficiency virus-associated nephropathyPrednisone Improves Renal Function and Proteinuria in Human Immunodeficiency Virus-associated Nephropathy5.10 HIV and renal diseaseHuman immunodeficiency virus-associated glomerulosclerosisOutcome of severe acute renal failure in patients with acquired immunodeficiency syndromeEffect of corticosteroid therapy on human immunodeficiency virus-associated nephropathyHuman Immunodeficiency Virus-Associated Nephropathy: Current ConceptsHIV-associated immune-mediated renal diseaseHuman Immunodeficiency Virus Infection and Glomerular DiseaseHuman Immunodeficiency Virus Infection and Nephrotic Syndrome 1 December 1990Volume 113, Issue 11Page: 892-893KeywordsBiopsyClinical pathologyDiagnostic medicineDrugsDyspneaHIVHIV infectionsLymph nodesProteinsRenal failure Issue Published: 1 December 1990 PDF DownloadLoading ...