A Novel Defect in Interferon- Secretion in Patients with Refractory Nontuberculous Pulmonary Mycobacteriosis
Authors: Amar Safdar, Donald Armstrong, Henry W. Murray
Journal: Annals of Internal Medicine (2003)

Letters18 March 2003A Novel Defect in Interferon- Secretion in Patients with Refractory Nontuberculous Pulmonary MycobacteriosisAmar Safdar, MD, Donald Armstrong, MD, and Henry W. Murray, MDAmar Safdar, MDMemorial Sloan-Kettering Cancer Center; New York, NY 10021 (Safdar, Armstrong)Weill Medical College of Cornell University; New York, NY 10021 (Murray)Search for more papers by this author, Donald Armstrong, MDMemorial Sloan-Kettering Cancer Center; New York, NY 10021 (Safdar, Armstrong)Weill Medical College of Cornell University; New York, NY 10021 (Murray)Search for more papers by this author, and Henry W. Murray, MDMemorial Sloan-Kettering Cancer Center; New York, NY 10021 (Safdar, Armstrong)Weill Medical College of Cornell University; New York, NY 10021 (Murray)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-6-200303180-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In immunocompetent persons, persistent or recurrent pulmonary mycobacteriosis due to nonMycobacterium tuberculosis has been linked to suboptimal T-cell production of interferon- (1-3). The mechanism for this association, however, is uncertain. We report a possible new cellular mechanism for interferon- deficiency in two women with the Lady Windermere syndrome (4) who had recurrentrefractory lung infection with M. avium and M. simiae. Both women were thin and had copious sputum production, modest thoracic bony abnormalities, bronchiectasis, and nodular pulmonary infiltrates (1).Cultures of peripheral blood mononuclear cells were established and stimulated for 48 hours, and extracellular interferon- was measured ...References1. Safdar A, White DA, Stover D, Armstrong D, Murray HW. Profound interferon deficiency in patients with chronic pulmonary nontuberculous mycobacteriosis. Am J Med. 2002;113:756-9. [PMID: 12517367] CrossrefMedlineGoogle Scholar2. Vankayalapati R, Wizel B, Samten B, Griffith DE, Shams H, Galland MR, et al. . Cytokine profiles in immunocompetent persons infected with Mycobacterium avium complex. J Infect Dis. 2001;183:478-84. [PMID: 11133380] CrossrefMedlineGoogle Scholar3. Huang JH, Oefner PJ, Adi V, Ratnam K, Ruoss SJ, Trako E, et al. . Analyses of the NRAMP1 and IFN-gammaR1 genes in women with Mycobacterium avium-intracellulare pulmonary disease. Am J Respir Crit Care Med. 1998;157:377-81. [PMID: 9476846] CrossrefMedlineGoogle Scholar4. Prince DS, Peterson DD, Steiner RM, Gottlieb JE, Scott R, Israel HL, et al. . Infection with Mycobacterium avium complex in patients without predisposing conditions. N Engl J Med. 1989;321:863-8. [PMID: 2770822] CrossrefMedlineGoogle Scholar5. Koehne G, Smith KM, Ferguson TL, Williams RY, Heller G, Pamer EG, et al. . Quantitation, selection, and functional characterization of Epstein-Barr virus-specific and alloreactive T cells detected by intracellular interferon- production and growth of cytotoxic precursors. Blood. 2002;99:1730-40. [PMID: 11861290] CrossrefMedlineGoogle Scholar6. Newport MJ, Huxley CM, Huston S, Hawrylowicz CM, Oostra BA, Williamson R, et al. . A mutation in the interferon--receptor gene and susceptibility to mycobacterial infection. N Engl J Med. 1996;335:1941-9. [PMID: 8960473] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Amar Safdar, MD; Donald Armstrong, MD; Henry W. Murray, MDAffiliations: Memorial Sloan-Kettering Cancer Center; New York, NY 10021 (Safdar, Armstrong)Weill Medical College of Cornell University; New York, NY 10021 (Murray) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNon-tuberculous mycobacterial infections in geriatric patients—A neglected and emerging problemBeyond antibiotics for pulmonary nontuberculous mycobacterial diseasePatients with Idiopathic Pulmonary Nontuberculous Mycobacterial Disease Have Normal Th1/Th2 Cytokine Responses but Diminished Th17 Cytokine and Enhanced Granulocyte-Macrophage Colony-Stimulating Factor ProductionNon-tuberculous mycobacterial pulmonary diseaseNontuberculous Mycobacterial Disease in Transplant RecipientsVulnerability to Nontuberculous Mycobacterial Lung Disease or Systemic Infection Due to Genetic/Heritable DisordersWhole-Blood Gene Expression in Pulmonary Nontuberculous Mycobacterial InfectionElucidating the Pathogenesis of Nontuberculous Mycobacterial Lung Disease: Lesson from the Six Blind Men and the ElephantHost susceptibility to non-tuberculous mycobacterial infectionsMycobacterium avium complex infection in non-cystic fibrosis bronchiectasisManagement of nontuberculous mycobacterial infection in the elderlyPatients with non-tuberculous mycobacterial lung disease have elevated transforming growth factor-beta following ex vivo stimulation of blood with live Mycobacterium intracellularePatients with Nontuberculous Mycobacterial Lung Disease Exhibit Unique Body and Immune PhenotypesAerosolized amikacin in patients with difficult-to-treat pulmonary nontuberculous mycobacteriosisIL-32 expression in the airway epithelial cells of patients with Mycobacterium avium complex lung diseaseInfections in Patients with Cancer: OverviewNontuberculous Mycobacterial InfectionsPathogenesis of Lady Windermere SyndromeInfections in 100 Cord Blood TransplantationsNon-tuberculous mycobacteria pulmonary infection: Management and follow-up of 31 infected patientsRecombinant interferon γ1b immune enhancement in 20 patients with hematologic malignancies and systemic opportunistic infections treated with donor granulocyte transfusionsLung Disease Due to the More Common Nontuberculous MycobacteriaAcneiform Granulomatous Folliculitis in a Patient with Interferon-γ Deficiency: Clearing with Empiric Antimycobacterial Therapy 18 March 2003Volume 138, Issue 6Page: 521KeywordsBlood cellsCellsCytokinesLungsPhytohemagglutininsSputumStainingT cell receptorsT cellsTuberculosis ePublished: 18 March 2003 Issue Published: 18 March 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...