Interim Guidance on the Eosinophilia-Myalgia Syndrome
Authors: Edwin M. Kilbourne
Journal: Annals of Internal Medicine (1990)

Editorial15 January 1990Interim Guidance on the Eosinophilia-Myalgia SyndromeEdwin M. Kilbourne, MD, Leslie A. Swygert, MD, Rossanne M. Philen, MD, Richard K. Sun, MD, MPH, Steven B. Auerbach, MD, MPH, Lynn Miller, DVM, MPH, David E. Nelson, MD, MPH, Henry Falk, MD, MPHEdwin M. Kilbourne, MDSearch for more papers by this author, Leslie A. Swygert, MDSearch for more papers by this author, Rossanne M. Philen, MDSearch for more papers by this author, Richard K. Sun, MD, MPHSearch for more papers by this author, Steven B. Auerbach, MD, MPHSearch for more papers by this author, Lynn Miller, DVM, MPHSearch for more papers by this author, David E. Nelson, MD, MPHSearch for more papers by this author, Henry Falk, MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-2-85 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Centers for Disease Control (CDC) has recently received a large volume of calls from physicians caring for patients with either clear-cut or suspected cases of the eosinophilia-myalgia syndrome, an apparently new clinical entity recently recognized as having occurred in epidemic form over at least the last several months ( 1 ). Because this epidemic was only recognized late in 1989, factual information about the disease is still limited. Work directed toward determining the full spectrum of clinical manifestations is still in progress, and optimal treatment and prognosis have not yet been determined.The observations and recommendations set forth here...References1. Eosinophilia-myalgia syndrome-New Mexico. MMWR. 1989;38:765-7. MedlineGoogle Scholar2. GrandjeanTarkowski PS eds. Toxic oil syndrome. Mass food poisoning in Spain. Report of a WHO meeting: Madrid, 21-25 March 1983. Copenhagen: World Health Organization Regional Office for Europe; 1984. Google Scholar3. Toxic epidemic syndrome: Spain, 1981. Toxic Epidemic Syndrome Study Group. Lancet. 1982;2:697-702. MedlineGoogle Scholar4. KilbourneRigau-PerezHeath EJC. Clinical epidemiology of toxic-oil syndrome. N Engl J Med. 1983;309:1408-14. CrossrefMedlineGoogle Scholar5. Martinez-TelloNavas-PalaciosRicoy FJJ. Pathology of a new toxic syndrome caused by ingestion of adulterated oil in Spain. Virchows Arch [A]. 1982;397:261-85. CrossrefMedlineGoogle Scholar6. Eosinophilia-myalgia syndrome and L-tryptophan-containing products-New Mexico, Minnesota, Oregon, and New York, 1989. MMWR. 1989;38:785-8. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Edwin M. Kilbourne, MD; Leslie A. Swygert, MD; Rossanne M. Philen, MD; Richard K. Sun, MD, MPH; Steven B. Auerbach, MD, MPH; Lynn Miller, DVM, MPH; David E. Nelson, MD, MPH; Henry Falk, MD, MPHAffiliations: Centers for Disease Control Atlanta, Georgia Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuantitative changes in blood cellsQuantitative Changes in Blood CellsEosinophilia-Myalgia Syndrome, Eosinophilic Fasciitis, and Related Fasciitis DisordersThe Eosinophilia Myalgia SyndromeEosinophilic Fasciitis (Shulman’s Syndrome): Case Reports and Review of the LiteraturePossible Lansoprazole-Induced Eosinophilic SyndromePopulation heterogeneity and its impact on the risk management of food safetyL-Tryptophan: Biochemical, nutritional and pharmacological aspectsHead and Neck Manifestations of Eosinophllia-Myalgia SyndromeChronic immune activation in the eosinophiliamyalgia syndromeIntensive rehabilitative approach to eosinophilia myalgia syndrome associated with severe polyneuropathySeparation and isolation of trace impurities in l-tryptophan by high-performance liquid chromatographyEosinophilia‐myalgia syndrome: lessons for public health researchersTryptophan metabolism via the kynurenine pathway in patients with the eosinophilia–Myalgia syndromePericrypt eosinophilic enterocolitis and chronic diarrheaReview of L-tryptophan and eosinophilia-myalgia syndromeScreening of Acute Psychiatric Admissions for Previously Undiagnosed Systemic Lupus ErythematosusGastrointestinal involvement inl-tryptophan (l-trp) associated eosinophilia-myalgia syndrome (EMS)Early impressions concerning actinomycetal infections that may play a role in the pathogenesis of eosinophilia-myalgia syndrome (EMS) and other ‘new illnesses’InsomniaEosinophilic fasciitis presenting with a reactive hepatitisPostoperative pain treated by intravenous l-tryptophan: a double-blind study versus placebo in cholecystectomized patientsDetection of antineutrophil cytoplasmic antibody in a patient with L-tryptophan induced eosinophilia-myalgia syndrome.Tryptophan Toxicity: A Pharmacoepidemiologic Review of Eosinophilia-Myalgia SyndromeNatural History of the Eosinophilia-Myalgia SyndromeRandall C. 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Dicker, BS, Nicholas James, MD, Burke A. Cunha, MDThe Eosinophilia-Myalgia SyndromeRonald J. Scheff, MD, Arturo R. Rolla, MDClinical spectrum of the systemic manifestations of the eosinophilia-myalgia syndromeL-Tryptophan Ingestion Associated with Eosinophilic Fasciitis but Not Progressive Systemic SclerosisBruce Freundlich, MD, Victoria P. Werth, MD, Alain H. Rook, MD, Carolyn R. O'Connor, MD, H. Ralph Schumacher, MD, James J. Leyden, MD, Paul D. Stolley, MDThe Eosinophilia-Myalgia SyndromeAndrew Freese, Stephen F. Finn, Matthew J. DuringEosinophilic fasciitis associated with the eosinophilia-myalgia syndromeTryptophan-Induced Eosinophilia–Myalgia SyndromeDevelopment of Diffuse Fasciitis with Eosinophilia during L-Tryptophan Treatment: Demonstration of Elevated Type I Collagen Gene Expression in Affected Tissues A Clinicopathologic Study of Four PatientsJohn Varga, MD, Juha Peltonen, MD, PhD, Jouni Uitto, MD, PhD, Sergio Jimenez, MDL-tryptophan and eosinophilia-myalgia syndrome in New MexicoA Case of the Eosinophilia-Myalgia Syndrome Associated with Use of an L-Tryptophan ProductMichael T. Flannery, MD, Paul M. Wallach, MD, Luis R. Espinoza, MD, Michael P. Dohrenwend, MD, Lynn C. Moscinski, MD 15 January 1990Volume 112, Issue 2Page: 85-87 ePublished: 1 December 2008 Issue Published: 15 January 1990 PDF downloadLoading ...