tbuckley/cabot-search huggingface dataset:
Athletic Shoe Dermatitis Contact Allergy to Ethyl Butyl Thiourea
Authors: Janet L. Roberts
Journal: JAMA (1979)

Ten patients with severe foot dermatitis were found to be highly allergic to innersole material prepared by Spenco Medical Corporation and used in Nike athletic shoes. Contact allergy testing showed sensitivity to ethyl butyl thiourea, a chemical accelerator in some neoprene (polychioroprene) rubber products. The dermatitis was recalcitrant and in many cases persisted long after discontinuance of wearing Nike shoes, raising the concern that traces of ethyl butyl thiorea or cross-reacting chemicals may be present in other footwear.
Frequency of Asymptomatic Shedding of Herpes Simplex Virus in Women With Genital Herpes
Authors: Brigit V. Brock
Journal: JAMA (1990)

Twenty-seven women with recurrent genital herpes simplex virus infection underwent daily home culturing to detect asymptomatic genital herpes simplex virus shedding. Asymptomatic herpes simplex virus shedding was documented on 1% of the days on which cultures were obtained. Asymptomatic shedding from the vulva was as frequent as asymptomatic cervicovaginal shedding, and 45% of asymptomatic episodes were identified only by positive results from vulvar cultures. All women who obtained samples on more than 100 days and 80% of women who obtained samples on more than 50 days had documented asymptomatic viral shedding, compared with only 6% of those who obtained samples for fewer than 25 days. Asymptomatic shedding was not related to contraceptive use or menstrual cycle. These data suggest that all women with recurrent genital herpes simplex virus infection should be instructed about the possible risk, albeit infrequent, of asymptomatically shedding virus from the genital tract.
Alder Hey pathologist is struck off medical register
Authors: Owen Dyer
Journal: BMJ (2005)

A pathologist has been struck off by the General Medical Council for storing thousands of children's body parts, against the wishes of their parents. Dick van Velzen became national news in 1999, when an inquiry at Liverpool's Alder Hey Hospital found that he had left thousands of jars containing children's organs to decay in a musty storeroom ( BMJ 2002;322: 255).

In many cases Dr van Velzen retained organs against the wishes expressed in parents' consent forms. He also falsely claimed to have returned …
The Cyanobacterial tRNALeu (UAA) Intron: Evolutionary Patterns in a Genetic Marker
Authors: José-Luis Costa, Per Paulsrud, Peter Lindblad
Journal: Molecular Biology and Evolution (2002)

Cyanobacterial tRNALeu (UAA) intron sequences from natural populations of Nostoc and other cyanobacteria were compared. Variation between the different introns was not randomly distributed but strongly restricted by the secondary and tertiary structure of the intron. Although all Nostoc sequences examined shared high similarity, differences were observed in one stem-loop. This stem-loop could be divided into two classes, both built up from two base pairing heptanucleotide repeats. Size variation was primarily caused by different numbers of repeats, but some strains also contained additional sequences in this stem-loop not following the heptanucleotide repeat motif. Several sequences showing similarity with these additional sequences were identified in the Nostoc punctiforme genome. Furthermore, the regions flanking these sequences contained the same, or similar, heptanucleotide repeats as those flanking the corresponding sequences in the intron. It is proposed that both slipped strand mispairing during replication and homologous recombination among different loci in the genome are important processes causing variation between introns.
Gene Expression Profiling of Inflamed Human Endothelial Cells and Influence of Activated Protein C
Authors: Nicola Franscini, Esther B. Bachli, Nenad Blau, Maria-Sybille Leikauf, Andreas Schaffner, Gabriele Schoedon
Journal: Circulation (2004)

During systemic inflammation, activation of vascular endothelium by proinflammatory cytokines leads to hypotension, microvascular thrombosis, and organ damage. Recent data suggest a link between coagulation and inflammation through the activated protein C (APC) pathway. We studied gene expression profiles in human coronary artery endothelial cells (HCAECs) exposed to proinflammatory stimuli and the influence of APC on expression of candidate genes regulated by these stimuli.HCAECs were stimulated with interleukin-1beta, interferon-gamma, and tumor necrosis factor-alpha. In gene expression profiling, 400 of 8400 genes were regulated >2-fold. Verification of selected candidate genes was achieved by measuring expression of mRNA species by real-time polymerase chain reaction, cytokine secretion by ELISA, and metabolites of tetrahydrobiopterin (BH4) biosynthesis by high-performance liquid chromatography. BH4 synthesis, interleukin-6, interleukin-8, monocyte chemotactic protein-1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) were downregulated by APC at the transcriptional and protein level. Endothelial nitric oxide synthase, endothelial adhesion molecule, and vascular cell adhesion molecule-1 were not affected by APC. Activities of transcription factors c-Fos, FosB, and c-Rel were inhibited by APC in inflamed HCAECs.Our study revealed a novel antiinflammatory mechanism of APC-dependent gene regulation in HCAECs since c-Fos-dependent induction of MCP-1 and ICAM-1 was suppressed. APC downregulates expression and activity of genes related to inflammation, most pronounced under intermediate or mild inflammatory conditions.
Complications and Other Surgical Outcomes Associated with Extended Pelvic Lymphadenectomy in Men with Localized Prostate Cancer
Authors: Alberto Briganti, Felix K.-H. Chun, Andrea Salonia, Nazareno Suardi, Andrea Gallina, Luigi Filippo Da Pozzo, Marco Roscigno, Giuseppe Zanni, Luc Valiquette, Patrizio Rigatti, Francesco Montorsi, Pierre I. Karakiewicz
Journal: European Urology (2006)
The Dependence of Neurology on Internal Medicine
Authors: R. E. Castelaw
Journal: JAMA (1910)

To the Editor:  I think the article by Drs. Joseph Collins and Pearce Bailey, of New York (The Journal, July 30, 1910, p. 393), was read with great interest and received extensive comment by those of us who are interested in the teaching of neurology. As a general proposition most of the premises advanced by the authors of this article are correct. All of us are agreed that neurology has been neglected, both in the lecture room and hospital ward, but the statement that In all America there is scarcely a general hospital with neurologic wards worthy of the name, etc., will not hold water. So with the statement The profession who teaches them having no hospital patients of their own can demonstrate only such patients as are able to walk to the clinic; and so on throughout the entire article are many statements that are really misleading and do
Relationships between PCBs and thyroid hormones and retinol in female and male polar bears.
Authors: Marte Braathen, Andrew E Derocher, Øystein Wiig, Eugen G Sørmo, Elisabeth Lie, Janneche U Skaare, Bjørn Munro Jenssen
Journal: Environmental Health Perspectives (2004)

We studied the relationships between polychlorinated biphenyls (PCBs) and thyroid hormones (THs) and retinol within two groups of female polar bears (Ursus maritimus), females with cubs of the year (FWCOY) and females without cubs of the year (FWOCOY), and within a group of males. Concentrations of five of the six quantified PCB congeners, i.e., PCB-99, PCB-153, PCB-156, PCB-180, PCB-194 (sigma PCB5), correlated with each other, whereas the concentrations of PCB-118 did not correlate with the other congeners. sigma PCB5 and PCB-118 did not differ between the three different groups of polar bears, and the plasma levels ranged from 16.7 to 203.2 ng/g wet weight (ww) for sigma PCB5 and from 0.09 to 0.93 ng/g ww for PCB-118. PCBs did not affect the retinol status in any of the three groups. In FWCOY, we found negative correlations between sigma PCB5 and the three TH variables free thyroxin (FT4) (r2 = 0.35), free triiodothyronine (FT3) (r2 = 0.30), and the total T4:total T3 ratio (TT4:TT3) (r2 = 0.92). In FWOCOY, sigma PCB5 was negatively correlated to TT4 (r2 = 0.14) and positively correlated to TT3:FT3 (r2 = 0.31), whereas PCB-118 was positively correlated to FT3 (r2 = 0.21) and negatively correlated to TT3:FT3 (r2 = 0.26). In males, sigma PCB5 was negatively correlated to FT3 (r2 = 0.56) and positively correlated to FT4:FT3 (r2 = 0.78), whereas PCB-118 was negatively correlated to FT4:FT3 (r2 = 0.53). Thus, PCBs affected five TH variables in the female polar bears (TT4, FT4, FT3, TT3:FT3, TT4:TT3), but PCBs affected only two TH variables in males (FT3, FT4:FT3). Female polar bears could be more susceptible to TH-related effects of PCBs than are males. PCBs also affected T3 to a larger degree than T4.
Risks of Spontaneous Injury and Extraction of an Active Fixation Pacemaker Lead
Authors: G. Neal Kay, Jeffrey A. Brinker, David T. Kawanishi, Charles J. Love, Margaret A. Lloyd, Russell C. Reeves, Guy Pioger, JoAnn Fee, Mary K. Overland, Lisa Garnsey Ensign, Gary L. Grunkemeier, for the Accufix Multicenter Clinical Study Investigators
Journal: Circulation (1999)

Background —The Telectronics Accufix pacing leads were recalled in November 1994 after 2 deaths and 2 nonfatal injuries were reported. This multicenter clinical study (MCS) of patients with Accufix leads was designed to determine the rate of spontaneous injury related to the J retention wire and results of lead extraction. Methods and Results —The MCS included 2589 patients with Accufix atrial pacing leads that were implanted at or who were followed up at 12 medical centers. Patients underwent cinefluoroscopic imaging of their lead every 6 months. The risk of J retention wire fracture was ≈5.6%/y at 5 years and 4.7%/y at 10 years after implantation. The annual risk of protrusion was 1.5%. A total of 40 spontaneous injuries were reported to a worldwide registry (WWR) that included data from 34 672 patients (34 892 Accufix leads), including pericardial tamponade (n=19), pericardial effusion (n=5), atrial perforation (n=3), J retention wire embolization (n=4), and death (n=6). The risk of injury was 0.02%/y (95% CI, 0.0025 to 0.072) in the MCS and 0.048%/y (95% CI, 0.035 to 0.067) in the WWR. A total of 5299 leads (13%) have been extracted worldwide. After recall in the WWR, fatal extraction complications occurred in 0.4% of intravascular procedures (16 of 4023), with life-threatening complications in 0.5% (n=21). Extraction complications increased with implant duration, female sex, and J retention wire protrusion. Conclusions —Accufix pacing leads pose a low, ongoing risk of injury. Extraction is associated with substantially higher risks, and a conservative management approach is indicated for most patients.
Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-β2 microglobulin–null mice
Authors: H. Glimm, W. Eisterer, K. Lee, J. Cashman, T.L. Holyoake, F. Nicolini, L.D. Shultz, C. von Kalle, C.J. Eaves
Journal: Journal of Clinical Investigation (2001)

Increasing use of purified or cultured human hematopoietic cells as transplants has revealed an urgent need for better methods to predict the speed and durability of their engraftment potential. We now show that NOD/SCID-beta2 microglobulin-null (NOD/SCID-beta2m-/-) mice are sequentially engrafted by two distinct and previously unrecognized populations of transplantable human short-term repopulating hematopoietic cells (STRCs), neither of which efficiently engraft NOD/SCID mice. One is predominantly CD34+CD38+ and is myeloid-restricted; the other is predominantly CD34+CD38- and has broader lymphomyeloid differentiation potential. In contrast, the long-term repopulating human cells that generate lymphoid and myeloid progeny in NOD/SCID mice engraft and self-renew in NOD/SCID-beta2m-/- mice equally efficiently. In short-term expansion cultures of adult bone marrow cells, myeloid-restricted STRCs were preferentially amplified (greater than tenfold) and, interestingly, both types of STRC were found to be selectively elevated in mobilized peripheral blood harvests. These results suggest an enhanced sensitivity of STRCs to natural killer cell-mediated rejection. They also provide new in vivo assays for different types of human STRC that may help to predict the engraftment potential of clinical transplants and facilitate future investigation of early stages of human hematopoietic stem cell differentiation.
Endoscopic Balloon Hydrodilatation and Endoprosthetic Treatment of Esophageal and Esophageal Anastomotic Strictures
Authors: Yu. I. Gallinger, A. F. Chernousov, A. L. Andreev, E. N. Vantsian
Journal: Endoscopy (1989)

In 37 patients with benign stenosis of the esophagus and esophageal anastomoses, the method of dilatation using special balloon catheters under endoscopic control was employed, and adequate dilatation of the stenotic region accomplished. In comparison with balloon dilators, bougies exert forces along the radial axis, and no tension is applied to the esophagus along the longitudinal axis. To obtain prolonged remission and decrease the number of "supporting" dilatations of esophageal benign stenosis and esophageal anastomoses, temporary intubation of the esophagus with a silicone prosthesis was performed in 7 patients. Further clinical application, and a study of the long-term results of endoscopic balloon hydro-dilatation and endoprosthesis for treating esophageal and anastomotic esophageal strictures, will help to elaborate more precise indications for the combined use of these methods.
Cell and Molecular Biology of the Incretin Hormones Glucagon-Like Peptide-I and Glucose-Dependent Insulin Releasing Polypeptide
Authors: HANS-CHRISTOPH FEHMANN, RÜDIGER GÖKE, BURKHARD GÖKE
Journal: Endocrine Reviews (1995)

THE presence of intestinal factors regulating the function of endocrine secretion from the pancreas was first described in 1906 by Moore and colleagues (1). The idea that humoral factors secreted from the gut might act in this way arose after the recognition of "secretin" as a regulator of pancreatic secretion. Later it became evident that the hypoglycemic intestinal factor(s) is/are not "secretin" and the names "incretin" and "duodenin" were introduced in the 1920s and 1930s to describe these putative mediators (2–4). For several decades the nature of this/these factor(s) remained largely unknown (5–8) and before the first incretin hormone was chemically characterized, several other hormones produced in the gastrointestinal tract were discovered. The connection between the gastrointestinal tract and the endocrine pancreas was shown in the 1960s when insulin became measurable in plasma. In these classic studies, the insulin response to oral glucose and intravenous glucose, resulting in nearly identical plasma glucose levels, was compared (9–11). A much higher insulin secretion was found after oral glucose. It was calculated that up to 50% of the insulin release after oral glucose is triggered by the "entero-insular-axis," a term introduced in 1969 (12).
Association Between Household and Workplace Smoking Restrictions and Adolescent Smoking
Authors: Arthur J. Farkas
Journal: JAMA (2000)

ContextRecent marked increases in adolescent smoking indicate a need for new prevention approaches. Whether workplace and home smoking restrictions play a role in such prevention is unknown.ObjectiveTo assess the association between workplace and home smoking restrictions and adolescent smoking.Design, Setting, and SubjectsData were analyzed from 2 large national population-based surveys, the Current Population Surveys of 1992-1993 and 1995-1996, which included 17,185 adolescents aged 15 to 17 years.Main Outcome MeasuresSmoking status of the adolescents surveyed, compared by presence of home and workplace smoking restrictions.ResultsAfter adjusting for demographics and other smokers in the household, adolescents who lived in smoke-free households were 74% (95% confidence interval [CI], 62%-88%) as likely to be smokers as adolescents who lived in households with no smoking restrictions. Similarly, adolescents who worked in smoke-free workplaces were 68% (95% CI, 51%-90%) as likely to be smokers as adolescents who worked in a workplace with no smoking restrictions. Adolescent smokers were 1.80 (95% CI, 1.23-2.65) times more likely to be former smokers if they lived in smoke-free homes. The most marked relationship of home smoking restrictions to current adolescent smoking occurred in households where all other members were never-smokers. Current smoking prevalence among adolescents in homes without smoking restrictions approached that among adolescents in homes with a current smoker but with smoking restrictions.ConclusionsParents with minor children should be encouraged to adopt smoke-free homes. Smoke-free workplaces can also augment smoking prevention. These findings emphasize the importance of tobacco control strategies aimed at the entire population rather than at youth alone.
CAPTOPRIL RENAL SCINTIGRAPHY PARAMETERS FOR DIAGNOSIS OF RENOVASCULAR HYPERTENSION
Authors: CC Chen, PB Hotter, A Gottschalk, K Koster, JF Setaro, HR Black
Journal: Clinical Nuclear Medicine (1989)

CC, Chen; PB, Hoffer; A, Gottschalk; K, Koster; JF, Setaro; HR, Black Author Information
Intestinal Bypass and Urine Oxalate
Authors: THOMAS A. GOLPER
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 July 1979Intestinal Bypass and Urine OxalateTHOMAS A. GOLPER, M.D., H. FREEMAN HARRIS, M.D., DONALD C. HOUGHTON, M.D.THOMAS A. GOLPER, M.D.Search for more papers by this author, H. FREEMAN HARRIS, M.D.Search for more papers by this author, DONALD C. HOUGHTON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-129_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their recently reported study of renalpathologic findings in patients after intestinal bypass surgery, Drenick and colleagues (1) observed "definite morphologic abnormalities . . . in all cases." We describe a clinically similar case in which kidney biopsy findings were normal.The patient presented to his private internist on 23 October 1978 after awakening that morning with painless gross hematuria. His medical history was significant for a successful jejunoileal intestinal bypass 2½ years earlier, with weight reduction from 147.4 to 85.3 kg. Glycosuria had been detected before the bypass, but renal function was reportedly normal. Intermittent, mild...Reference1. DRENICKSTANLEYBORDER ETW. Renal damage with intestinal bypass. Ann Intern Med. 1978;89 (Part 1):594-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Oregon Health Sciences Center Portland, OR 97201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1979Volume 91, Issue 1Page: 129-130KeywordsBiopsyKidneysSurgeryUrineWeight loss Issue Published: 1 July 1979 PDF DownloadLoading ...
Opinions of Dutch Physicians, Nurses, and Citizens on Health Care Policy, Rationing, and Technology
Authors: Tjeerd Tymstra
Journal: JAMA (1993)

In many Western countries, there is in-depth discussion about the health care system: how should the services be distributed and what criteria should play a role? The Dutch health care system is also under debate. In the Netherlands, public policy aims at ensuring that everyone has access to necessary health care. To this end, a system of compulsory and voluntary insurances has been organized. In the Netherlands, both the public and private sectors make significant contributions to the health care services. Government regulations cover physician fees, hospital budgets, new medical technologies, and the provision of hospital beds. Some 62% of the population—the lower-income groups—obtain health services through the<i>ziekenfonds</i>, or sickness funds. The remaining 38% of the population purchase private health insurance from nonprofit and profit-making insurance companies. General practitioners are paid on a capitation basis for patients in the sickness funds and on a fee-for-service basis for patients with
Omissions from A Library for Internists
Authors: PERRY J. RUSH
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 June 1988Omissions from A Library for InternistsPERRY J. RUSH, M.D.PERRY J. RUSH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-913_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: As an internist trained in physical medicine and rehabilitation, I was struck by the glaring omission of this field in A Library for Internists VI (1). It is surprising that rehabilitation should not be at least an area of special interest to internists similar to that of radiology or nutrition. Rehabilitation should be of particular interest to internists with training in rheumatology, neurology, cardiology, and respirology. Recent, comprehensive textbooks are available (2).Internists have all too often only been concerned with acute disease and have ignored the functional impairments and resulting disabilities of chronic diseases and their...References1. HUTH E. A library for internists VI: recommendations from the American College of Physicians. Ann Intern Med. 1988;108:497-510. LinkGoogle Scholar2. KOTTKESTILLWELLLEHMANN FGJ eds. Krusen's Handbook of Physical Medicine and Rehabilitation. 3rd ed. Philadelphia: W. B. Saunders Co.; 1982. Google Scholar3. . The task force on the future internist. Ann Intern Med. 1988;108:139-41. LinkGoogle Scholar4. . Attributes of the subspecialist in internal medicine, with guidelines for training. Arthritis Rheum. 1977;20:1282-5. CrossrefMedlineGoogle Scholar5. HICKSNICHOLAS JJ. Rehabilitative rheumatology content in current rheumatology training programs. Arthritis Rheum. 1984;27:1076-8. CrossrefMedlineGoogle Scholar1. HUTH E. A library for internists VI: recommendations from the American College of Physicians. Ann Intern Med. 1988;108:497-512. LinkGoogle Scholar2. LEWIS C. A library for internists V: recommended by the American College of Physicians. Ann Intern Med. 1985;102:423-37. LinkGoogle Scholar3. WEINBERG A. Principles and Practice of Infectious Diseases, [Book Review]. New Engl J Med. 1986;314:259. CrossrefGoogle Scholar4. CAUSEY W. Infectious diseases [Book Review]. JAMA. 1985;253:3324-5. CrossrefGoogle Scholar5. WINKELMANN B. Reviewing Goodman and Gilman's [Letter]. Ann Intern Med. 1986;104:897. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mount Sinai Hospital University of Toronto Toronto, Ontario PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1988Volume 108, Issue 6Page: 913-913KeywordsDiagnostic radiologyDisabilitiesLibrariesNeurologyNutritionRehabilitation medicineRheumatology Issue Published: 1 June 1988 PDF DownloadLoading ...
Centralized System for Collection and Analysis of Data on Patients in the USSR
Authors: ALEXANDER S. KISELEV
Journal: American Journal of Psychiatry (1972)

A great need exists for information on the morbidity rates of diseases, especially of psychiatric disorders. The author describes a mathematically based model currently being used in the USSR in which physicians are required to register each patient. It is hoped that the system will provide extensive information about morbidity rates for psychiatric disorders and about the demographic characteristics of various population groups that will be useful in planning and administering psychiatric services.