tbuckley/cabot-search huggingface dataset:
HLA-DQB1 alleles in Italian patients with mucous membrane pemphigoid predominantly affecting the oral cavity.
Authors: M. Carrozzo, M.E. Fasano, R. Broccoletti, M. Carbone, E. Cozzani, S. Rendine, S. Roggero, A. Parodi, S. Gandolfo
Journal: British Journal of Dermatology (2001)

Journal Article HLA‐DQB1 alleles in Italian patients with mucous membrane pemphigoid predominantly affecting the oral cavity Get access M. Carrozzo, M. Carrozzo Department of Clinical Physiopathology, Oral Medicine Section, and Department of Genetics, Biology and Biochemistry, School of Medicine and Dentistry, University of Turin, C.so Dogliotti 14, I‐10126 Turin, Italy Dr Marco Carrozzo. E‐mail: Mcarro@tin.it Search for other works by this author on: Oxford Academic Google Scholar M.E. Fasano, M.E. Fasano UAOD, Transplant Immunology, Molinette Hospital, Turin, Italy Search for other works by this author on: Oxford Academic Google Scholar R. Broccoletti, R. Broccoletti Department of Clinical Physiopathology, Oral Medicine Section, and Department of Genetics, Biology and Biochemistry, School of Medicine and Dentistry, University of Turin, C.so Dogliotti 14, I‐10126 Turin, Italy Search for other works by this author on: Oxford Academic Google Scholar M. Carbone, M. Carbone Department of Clinical Physiopathology, Oral Medicine Section, and Department of Genetics, Biology and Biochemistry, School of Medicine and Dentistry, University of Turin, C.so Dogliotti 14, I‐10126 Turin, Italy Search for other works by this author on: Oxford Academic Google Scholar E. Cozzani, E. Cozzani DISEM, Dermatology Section, University of Genoa, Italy Search for other works by this author on: Oxford Academic Google Scholar S. Rendine, S. Rendine Department of Clinical Physiopathology, Oral Medicine Section, and Department of Genetics, Biology and Biochemistry, School of Medicine and Dentistry, University of Turin, C.so Dogliotti 14, I‐10126 Turin, Italy Search for other works by this author on: Oxford Academic Google Scholar S. Roggero, S. Roggero UAOD, Transplant Immunology, Molinette Hospital, Turin, Italy Search for other works by this author on: Oxford Academic Google Scholar A. Parodi, A. Parodi DISEM, Dermatology Section, University of Genoa, Italy Search for other works by this author on: Oxford Academic Google Scholar S. Gandolfo S. Gandolfo Department of Clinical Physiopathology, Oral Medicine Section, and Department of Genetics, Biology and Biochemistry, School of Medicine and Dentistry, University of Turin, C.so Dogliotti 14, I‐10126 Turin, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 5, 1 November 2001, Pages 805–808, https://doi.org/10.1046/j.1365-2133.2001.04448.x Published: 01 November 2001
The Clinical Spectrum of the Acquired Immunodeficiency Syndrome: Implications for Comprehensive Patient Care
Authors: PAUL A. VOLBERDING
Journal: Annals of Internal Medicine (1985)

The clinical spectrum of the acquired immunodeficiency syndrome (AIDS) is broad and presents unique challenges to the health care system. Among the challenges are the unusual presentations, unexpected complications, psychosocial sequelae, and poor outcome of patients with the syndrome. From our experience with hundreds of patients at the San Francisco General Hospital, we propose a system for optimal care for patients with AIDS that requires a high degree of planning and commitment by hospitals and health care providers. In this model, rigid subspecialization is avoided, outpatient care is stressed, and community involvement is solicited. In these ways we can hope to improve the care of patients with AIDS and learn lessons that should be important in other illnesses as well.
An enzymatic method for distinguishing the stereoisomers of 12-hydroxyeicosatetraenoic acid in human epidermis and psoriatic scale
Authors: E.E. OPAS, L.W. ARGENBRIGHT, J.L. HUMES
Journal: British Journal of Dermatology (1989)

Homogenates of normal human epidermis synthesized 12-hydroxyeicosatetraenoic acid (12-HETE) when incubated in vitro with arachidonic acid. The stereoconfigurations of the C-12 hydroxyl isomers were determined by incubation with potato 5-lipoxygenase. The synthesized substrate-specific diHETEs; 5S, 12R and 5S, 12S, were readily separated by high performance liquid chromatography. Using this novel methodology, the normal epidermis was found to synthesize predominantly 12-S-HETE while, in contrast, psoriatic scale was found to contain 12-R-HETE. The 5-lipoxygenase inhibitors, Merck L-651, 896, Takeda AA86I, and the active metabolite of Syntex lonapalene were found to inhibit 12-HETE formation in normal epidermal homogenates.
Minimal RB-responsive E1A Promoter Modification to Attain Potency, Selectivity, and Transgene-arming Capacity in Oncolytic Adenoviruses
Authors: Juan J Rojas, Sonia Guedan, Peter F Searle, Jordi Martinez-Quintanilla, Raúl Gil-Hoyos, Francisca Alcayaga-Miranda, Manel Cascallo, Ramon Alemany
Journal: Molecular Therapy (2010)

Oncolytic adenoviruses are promising anticancer agents due to their ability to self-amplify at the tumor mass. However, tumor stroma imposes barriers difficult to overcome by these agents. Transgene expression is a valuable strategy to counteract these limitations and to enhance antitumor activity. For this purpose, the genetic backbone in which the transgene is inserted should be optimized to render transgene expression compatible with the adenovirus replication cycle and to keep genome size within the encapsidation size limit. In order to design a potent and selective oncolytic adenovirus that keeps intact all the viral functions with minimal increase in genome size, we inserted palindromic E2F-binding sites into the endogenous E1A promoter. The insertion of these sites controlling E1A-Δ24 results in a low systemic toxicity profile in mice. Importantly, the E2F-binding sites also increased the cytotoxicity and the systemic antitumor activity relative to wild-type adenovirus in all cancer models tested. The low toxicity and the increased potency results in improved antitumor efficacy after systemic injection and increased survival of mice carrying tumors. Furthermore, the constrained genome size of this backbone allows an efficient and potent expression of transgenes, indicating that this virus holds promise for overcoming the limitations of oncolytic adenoviral therapy. Oncolytic adenoviruses are promising anticancer agents due to their ability to self-amplify at the tumor mass. However, tumor stroma imposes barriers difficult to overcome by these agents. Transgene expression is a valuable strategy to counteract these limitations and to enhance antitumor activity. For this purpose, the genetic backbone in which the transgene is inserted should be optimized to render transgene expression compatible with the adenovirus replication cycle and to keep genome size within the encapsidation size limit. In order to design a potent and selective oncolytic adenovirus that keeps intact all the viral functions with minimal increase in genome size, we inserted palindromic E2F-binding sites into the endogenous E1A promoter. The insertion of these sites controlling E1A-Δ24 results in a low systemic toxicity profile in mice. Importantly, the E2F-binding sites also increased the cytotoxicity and the systemic antitumor activity relative to wild-type adenovirus in all cancer models tested. The low toxicity and the increased potency results in improved antitumor efficacy after systemic injection and increased survival of mice carrying tumors. Furthermore, the constrained genome size of this backbone allows an efficient and potent expression of transgenes, indicating that this virus holds promise for overcoming the limitations of oncolytic adenoviral therapy.
Association of Juxtapapillary Diverticula with Choledocholithiasis but not with Cholecystolithiasis
Authors: H. Hagège, A. Berson, G. Pelletier, J. Fritsch, A. Choury, C. Liguory, J. P. Etienne
Journal: Endoscopy (1992)

Juxtapapillary diverticula are often associated with biliary lithiasis. The aim of this study was to compare the prevalence of juxtapapillary diverticula in choledocholithiasis and in cholecystolithiasis without common bile duct stones. The results of 520 consecutive retrograde cholangiographies were retrospectively analysed. The prevalence of juxtapapillary diverticula was higher in patients with biliary lithiasis than in patients without: 26.0% vs 10.5% (p less than 0.001). However, juxtapapillary diverticula were more frequently encountered in patients with choledocholithiasis than in those with gallbladder lithiasis or previous cholecystectomy and a stone-free common bile duct: 40.0% vs 10.2% (p less than 0.001). There was no significant difference between the patients with cholecystolithiasis alone and those without biliary lithiasis. Among the patients with previous cholecystectomy or with gallbladder lithiasis, common bile duct stones were more frequently found in patients with juxtapapillary diverticula than in those without: 80.3% vs 40.6% (p less than 0.001). These data suggest that juxtapapillary diverticula are associated only with choledocholithiasis and not with gallbladder lithiasis.
Time to Diagnosis of Ewing Tumors in Children and Adolescents Is Not Associated With Metastasis or Survival: A Prospective Multicenter Study of 436 Patients
Authors: Jean-François Brasme, Martin Chalumeau, Odile Oberlin, Dominique Valteau-Couanet, Nathalie Gaspar
Journal: Journal of Clinical Oncology (2014)

Purpose The time to diagnosis (TtD) of Ewing tumors is one of the longest among pediatric tumors. Its precise consequences, however, have not been studied well. We analyzed the distribution of TtD for Ewing tumors in children and adolescents and its association with clinical features, tumor characteristics, surgical outcome, and long-term survival. Patients and Methods We analyzed prospectively collected data from two multicenter clinical trials of patients younger than 21 years old who had Ewing bone tumors treated in France between 1988 and 2000. Clinical and tumoral features, TtD, and outcome associations were studied by univariable and multivariable analyses. Results The median TtD for the 436 patients was 70 days (interquartile range, 27 to 146 days), with no significant decrease during the study period (P &gt; .2). The factors associated with long TtD were older age and some tumor sites (pelvis, extremities of limbs). Increased tumor volume and decreased histologic response to chemotherapy were associated with long TtD on univariable analysis (P &lt; .05) but not after adjustment. Presence of a nerve or spinal-cord compression at diagnosis, presence or site of metastasis, surgical treatment, mutilating surgery, complete resection, or survival were not associated with TtD. Conclusion TtD of Ewing tumors was long, especially for adolescents and for certain tumor sites, and did not improve over time. But TtD was not associated with metastasis, surgical outcome, or survival. These findings could be used to comfort parents at diagnosis and in expert testimony produced for malpractice claims.
Does progression from actinic keratosis and Bowen's disease end with treatment: diclofenac 3% gel, an old drug in a new environment?
Authors: M. J. Patel, E. Stockfleth
Journal: British Journal of Dermatology (2007)

Progression from actinic keratosis (AK) and Bowen's disease (BD) to invasive disease involves a complex cascade of events. The preparation of diclofenac 3% gel (Solaraze; Shire Pharmaceuticals) has been shown to be efficacious and well tolerated in AK. The inhibition of the COX enzymes results in a decrease in downstream by-products of arachidonic acid metabolism. These metabolites have been shown to play a pivotal role in promoting epithelial tumour growth. Given its mechanism of action, we hypothosize that diclofenac 3% gel may have potential to halt the progression of actinic keratoses (AKs) in the setting of field cancerisation and BD. We report a series of five patients with BD, all treated with diclofenac 3% gel with clinical and histological clearance.
Antithrombotic therapy for deep arterial injury by angioplasty. Efficacy of common platelet inhibition compared with thrombin inhibition in pigs.
Authors: J Y Lam, J H Chesebro, P M Steele, M Heras, M W Webster, L Badimon, V Fuster
Journal: Circulation (1991)

Platelet-thrombus formation is a complication of arterial wall deep injury by balloon angioplasty that may lead to acute arterial occlusion and may contribute to restenosis.Because common platelet-inhibitor drugs with a heparin bolus (100 units/kg) may be effective in inhibiting platelet-thrombus formation after arterial angioplasty, these were compared with a bolus of heparin alone (control), the specific thrombin inhibitor hirudin (1.0 mg/kg), and saline (hirudin control) in normal pigs after angioplasty of the common carotid arteries. In the presence of deep arterial wall injury (injury exposing the media), indium-111-labeled platelet deposition (x 10(6)/cm2) was 68.8 +/- 12.3 and 48.1 +/- 16.9 in the control animals. This was significantly reduced by pretreatment with low-dose aspirin (1 mg/kg/day), by high-dose aspirin (20 mg/kg/day) plus dipyridamole, and especially by thrombin inhibition with hirudin. Treatment regimens with aspirin alone (20 mg/kg/day), dipyridamole alone, or sulfinpyrazone were ineffective. Likewise, the incidence of mural thrombosis was 75% and 80% in deeply injured arteries of controls and was significantly reduced to 46% with aspirin plus dipyridamole, 25% with low-dose aspirin, and 0% with hirudin. The incidence of mural thrombosis was unchanged with high-dose aspirin (69%), dipyridamole (90%), or sulfinpyrazone (92%). This mural thrombosis could not be identified by angiography. In the presence of mild injury (deendothelialization), platelet deposition was low (less than 10 x 10(6)/cm2, a single layer) and was not changed by any therapy, including hirudin.These therapies do not affect platelet adhesion to deeply or mildly injured artery. These data suggest a greater role for thrombin inhibition than with thromboxane or cyclooxygenase inhibition in the pathogenesis of platelet-rich mural thrombosis after deep injury during angioplasty. Antithrombotic therapy for arterial thrombosis by thrombin inhibition appears promising.
Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine
Authors: William W. Busse, Stephen P. Peters, Matthew J. Fenton, Herman Mitchell, Eugene R. Bleecker, Mario Castro, Sally Wenzel, Serpil C. Erzurum, Anne M. Fitzpatrick, W. Gerald Teague, Nizar Jarjour, Wendy C. Moore, Kaharu Sumino, Scott Simeone, Suphagaphan Ratanamaneechat, Madhuri Penugonda, Benjamin Gaston, Ted M. Ross, Steve Sigelman, Joella R. Schiepan, Daniel J. Zaccaro, Corey J. Crevar, Donald M. Carter, Alkis Togias
Journal: Journal of Allergy and Clinical Immunology (2010)
CASE OF THREATENED AMPUTATION, THE RESULT OF A SIMPLE FRACTURE OF THE LEG BECOMING COMPOUND
Authors: J. Churchill
Journal: BMJ (1854)

pevalent in the summer and autumn of 1852 in many other pr-ts of the country, and not more fatal than in Bedford and its neighbourhood,-the onLy means of ascertaining that fact will be through the journals; for the tables of mortality will render us no assistance.
Computer-Assisted Diagnosis
Authors: Herbert S. Wax man
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 October 1990Computer-Assisted DiagnosisHerbert S. Wax man, MD, William E. Worley, MDHerbert S. Wax man, MDSearch for more papers by this author, William E. Worley, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-7-561_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In January and again in May, Annals published reviews of Meditel, a computer-assisted diagnosis software system (1, 2). That the reviewers' conclusions differed may reflect the lack of criteria for appropriate medical expert review of system software, an important point first raised in Annals in 1984 by the late Marsden Blois (3), a true pioneer in medical informatics.Dr. Roth (2), the May reviewer, concluded that Meditel fell "far short of its claim" to be "an office-based tool with a list of 1160 differential diagnoses." In fact, Meditel has 1160 diagnoses in its knowledge base. (Other systems...References1. Adler A. Meditel: computer assisted diagnosis. Ann Intern Med. 1990;112:154. LinkGoogle Scholar2. Roth R. Meditel: computer assisted diagnosis. Ann Intern Med. 1990;112:719. LinkGoogle Scholar3. Blois M. Critical review of software [Letter]. Ann Intern Med. 1984;101:139-40. LinkGoogle Scholar4. HammersleyCooney JK. Evaluating the utility of available differential diagnosis systems. Proceedings of the Twelfth Annual Symposium on Computer Applications in Medical Care. Washington, DC: IEEE Computer Society Press; 1988:229-321. Google Scholar5. WaxmanWorley HW. Computer-assisted medical diagnosis: subject review and evaluation of a new microcomputer-based system. Medicine. 1990;69:125-36. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTesting System AccuracyComputer-assisted diagnosis of rheumatic disorders 1 October 1990Volume 113, Issue 7Page: 561-561KeywordsComputer softwareComputing systemsSystematic reviews Issue Published: 1 October 1990 PDF DownloadLoading ...
Helicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy.
Authors: D Heresbach, J L Raoul, J F Bretagne, J Minet, P Y Donnio, M P Ramee, L Siproudhis, M Gosselin
Journal: Gut (1992)

This prospective study aimed to determine the prevalence of Helicobacter pylori infection in relation to the occurrence and severity of NSAIDs induced gastropathy. A total of 111 patients were studied-66 were taking NSAIDs and 45 were control patients. All patients underwent endoscopy during which antral biopsy specimens were taken to determine H pylori status (Gram and Giemsa staining, urease test, and cultures). The NSAID group comprised: group I, patients without mucosal damage (n = 28); group II, patients with gastropathy (n = 26); and group III, patients with bleeding associated with NSAID induced gastropathy (n = 12). Control patients had neither dyspeptic symptoms nor endoscopic lesions. There were no differences in age, sex ratio, or presence of H pylori (26% v 24%) between the NSAID and the control groups. Among patients taking NSAIDs, H pylori infection was more frequently (p < 0.02) diagnosed in those who presented with gastropathy (groups II and III: 37%) than in those without lesions (group I: 11%). The frequency of H pylori infection increased significantly with the severity of gastropathy (group I = 11%; group II = 31%; group III = 50%; p < 0.03). H pylori infection was associated with chronic active gastritis (group I = 21%; group II = 35%; group III = 67%; p < 0.05). These data suggest that H pylori may be a risk factor of NSAID induced gastropathy.
Good engineering is not good medicine
Authors: S. Ong
Journal: BMJ (1998)

“What are you doing with the rest of your life?” I was 18 and didn't quite know. My Dad wanted me to be an engineer. I thought I wanted to be a doctor.

On Tuesday mornings I would stare out the classroom window. Our physics teacher tried in vain to convey to us the incomprehensible. He told us about quantum mechanics, fission, and the theory of …
Sex and Urinary Tract Infections
Authors: Allan Ronald
Journal: New England Journal of Medicine (1996)

The association between sexual intercourse and acute cystitis in women has been recognized for generations in folk wisdom (e.g., “honeymoon cystitis”), but researchers have been less certain of this association.1 In fact, a causal relation between two very common events, intercourse and acute cystitis, is difficult to establish.Several studies have linked urinary tract infections to heterosexual intercourse. Kunin and McCormack noted that nuns had a lower prevalence of bacteriuria than other populations of women during early adult life.2 Buckley et al.3 reported an increase in bacterial counts in the urine after intercourse in 30 percent of women, and Nicolle . . .
Reconceiving the Relationship and Supporting Physician Responsibility
Authors: David Alfandre
Journal: The American Journal of Bioethics (2012)

Click to increase image sizeClick to decrease image size Acknowledgments This article is not subject to U.S. copyright law. The views expressed in this article are those of the author and do not necessarily reflect the position or policy of the U.S. Department of Veterans Affairs or the National Center for Ethics in Health Care.
Labour and birth in water in England and Wales
Authors: F. Alderdice, M. Renfrew, S. Marchant, H. Ashurst, P. Hughes, G. Berridge, J. Garcia
Journal: BMJ (1995)

In 1992 the House of Commons Health Committee's report on the maternity services recommended that all hospitals should provide women with “the option of a birthing pool where this is practicable.”1 The lack of relevant research on labour and birth in water2 prompted the Department of Health to fund this survey.

### and results

All 219 identified heads of midwifery, or equivalent, in NHS provider units in England and Wales were sent a short postal questionnaire in October 1993. All questionnaires were returned, and telephone interviews were subsequently carried out with a nominated respondent from each provider unit. Three units were omitted in error as a result of the difficulty of identifying these units at a time of organisational change in the NHS.

Labour or birth in water, or both, had occurred in all provider units (in hospital and community practice) at some time, either in purpose made birthing …
Acute Diarrhea — A Toxin Disease?
Authors: Sherwood L. Gorbach
Journal: New England Journal of Medicine (1970)

Dysentery of this Arabian coast sort used to fall like a hammer blow and crush its victims for a few hours, after which the extreme effects passed off; but it left men curiously tired.T. E. LawrenceAcute diarrhea has confounded several generations of clinicians and microbiologists. What could be more frustrating than the inability to identify pathogens in 80 per cent of acute gastroenteritis cases — a disease that afflicts approximately 200,000,000 children and adults on any given day of the year? Cryptic appellations such as "nonspecific gastroenteritis," "acute undifferentiated diarrhea" and "summer diarrhea" have been assigned to this . . .
Lumbar puncture in adult bacterial meningitis: time to reconsider guidelines?
Authors: M. Glimaker, L. Lindquist, J. Sjolin
Journal: BMJ (2013)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Lumbar puncture in adult bacterial meningitis: time to reconsider guidelines? Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Allergy to diazepam.
Authors: M Lader
Journal: BMJ (1977)

whereas 19 % of the women on diuretics had hypokalaemia of varying degrees.My conclusions are that the evidence in favour of a general recommendation of potassium supplementation in elderly, non- digitalised cardiac patients on diuretics is insufficient and that elderly women are prob- ably more prone to diuretic-associated hypo- kalaemia than elderly men.R