tbuckley/cabot-search huggingface dataset:
DEVELOPING A TEACHING OUTLINE: AN 11+ IMPLEMENTATION STUDY IN NIGERIA
Authors: U Bakare, E Ogunkunle
Journal: British Journal of Sports Medicine (2014)

Objective To provide information from practice based evidence on the structure of teaching the protocol of “11+” to potential instructors for coaches/handlers of teams as part of an on-goin implementation study. Methods Prequel to an implementation study of the "11+" included sytematic recruitment of interested persons, taking them through a course of training in the Protocol using a self-developed syllabus for two-hours per session over a course of 16 sessions. The individuals recruited were in 2011 and 2012 designated as group A and B respectively. Considerations: 1) The majority of the group of interested people trained can be classified as relatively active but not athletic, 2) Applying principles of exercise training which should be carried out progressively from low intensity to transition accordingly, 3) Time frame allocated at the training venue THE GRANGE SCHOOL IKEJA, LAGOS where the team had access pitch/classroom for a period of two hours for free on Saturdays. Results Group A completed thier training over a course of 16 weeks which helped in developing a teaching syllabus in 2012. The specified number of sessions was adequate to transfer knowledge effectively from Group A to Group B and equip participants effectively to prepare to teach potential target audience without being lost in translation. It created an opportunity for GROUP A to develop their teaching, technical ability and time management over the course of the sessions. It also created a template adoptable for implementation structure when training coaches/handlers/teams. Conclusion It is pertinent to have implementation strategies clearly outlined and structured to facilitate better outcomes of learning which may differ from place to place considering a host of factors contributing to affecting the implementation plan. The 16 sessions proposed is deemed adequate but can be completed in a shorter timeline if there is access to facilities for training and funding to facilitate program. The need for research outcome implemetation to target population.
Sorbitol can be the cause of colonic explosion
Authors: R. Rerknimitr
Journal: Endoscopy (2007)

I read the article by Josemanders et al., ”Colonic explosion during endoscopic polypectomy: avoidable complication or bad luck?” with great interest [1]. They concluded that ”the occurrence of intracolonic gas explosion during polypectomy is, practically, an unavoidable complication.” However, the cleansing solution that they used in their patient contained sorbitol, which I believe can yield products that are combustible after bacterial fermentation. Generally, explosion is a rare event during electrocautery treatment in the colon. The cause of the explosion is ignition of gas containing hydrogen (at concentrations greater than 4 %) or methane (at concentrations greater than 5 %), and oxygen [2].
Cellular Arrhythmogenic Effects of Congenital and Acquired Long-QT Syndrome in the Heterogeneous Myocardium
Authors: Prakash C. Viswanathan, Yoram Rudy
Journal: Circulation (2000)

Background —Certain alterations by mutations or drugs of the potassium currents I Ks and I Kr and the sodium current I Na give rise to several types of the long-QT syndrome. I Ks is heterogeneously distributed across the ventricular wall. Methods and Results —We investigated the effects of reducing I Ks or I Kr or enhancing late I Na (to simulate the 3 forms of long-QT syndrome) on action potential duration (APD) in the context of I Ks heterogeneity. We introduced I Ks heterogeneity in the Luo-Rudy dynamic cell model to simulate epicardial, endocardial, and midmyocardial (M) cells. Results demonstrated higher susceptibility of M cells to the development of arrhythmogenic early afterdepolarizations (EADs) in isolated cells and poorly coupled tissue. An important observation is that I Kr block or late I Na acts to increase APD differences between the cell types, whereas I Ks block minimizes such differences. Also, for normal transverse coupling, EADs develop in the endocardial region rather than in the M region as the result of strong electrotonic interaction. Conclusions — I Ks heterogeneity and intercellular coupling strongly influence EAD development during interventions or disorders that prolong APD. M cells in isolation or in poorly coupled tissue are more susceptible to EAD development than epicardial or endocardial cells. In well-coupled myocardium, EAD formation in the subendocardium can be the source of focal arrhythmias or provide the trigger for reentrant excitation. The efficacy of I Ks block in minimizing APD dispersion could have important implications for antiarrhythmic therapy.
Type I Allergy to Normal Cellular Constituents in Chronic Inflammatory Bowel Disease?
Authors: J. Elmgreen, P. Stahl Skov, H. Permin, V. Binder, J. Heugh Wandall, S. Norm
Journal: Allergy (1984)

The possibility of autoimmune type I reactions to cellular constituents was investigated in 22 patients with ulcerative colitis, 12 with Crohn's disease, and in 22 healthy volunteers Nuclear components and colon mucosa fragments were tested as potential antigens by the basophil histamine release technique One of 12 patients with ulcerative colitis responded to sonicated leukocyte nuclei and one of 12 patients with Crohn's disease responded to both nuclei and RNA. Increased serum levels of total IgE and antinuclear antibodies of IgE class were found in one and three of the 24 patients, respectively Histamine release caused by colon mucosa fragments was not observed in a separate study consisting of 10 ulcerative colitis patients and 10 healthy volunteers. Autoimmune type I allergy to cellular‘constituents does not seem to be of significance for chronic inflammatory bowel disease and thus could not explain the involvement of tissue mast cells and eosinophils in this condition
Ballistocardiographic Study in Severe Anemia
Authors: O. P. TANDON, B. C. KATIYAR
Journal: Circulation (1961)

Ballistocardiographic study in 10 cases of chronic severe anemia, with use of Dock's direct body ballistocardiograph, has been reported. The tracings were studied before and after treatment of anemia. All cases showed abnormal ballistocardiograms. The abnormalities presented no specific pattern. Prior to treatment, in the majority of cases, the waves were smaller than normal. With few exceptions, the tracings tended to regain their normal size on correction of anemia. No tracings showed fused HJ complexes, tall H waves, notched J waves, M patterns, or high-amplitude curves either before or after treatment. The present study shows that the state of severe anemia of chronic duration, impairs the mechanical force of cardiac contractions, and, on improvement of anemia, the functional state of the heart improves. Thus, it reflects the usefulness of this new tool in assessing the functional status of the heart in patients with chronically severe anemia.
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
Authors: Christopher Newton-Cheh, Martin G Larson, Ramachandran S Vasan, Daniel Levy, Kenneth D Bloch, Aarti Surti, Candace Guiducci, Sekar Kathiresan, Emelia J Benjamin, Joachim Struck, Nils G Morgenthaler, Andreas Bergmann, Stefan Blankenberg, Frank Kee, Peter Nilsson, Xiaoyan Yin, Leena Peltonen, Erkki Vartiainen, Veikko Salomaa, Joel N Hirschhorn, Olle Melander, Thomas J Wang
Journal: Nature Genetics (2009)
Plasticity of Cortical Activation Related to Working Memory During Training
Authors: Albrecht Hempel, Frederik L. Giesel, Nohazarahit M. Garcia Caraballo, Michael Amann, Heiko Meyer, Torsten Wüstenberg, Marco Essig, Johannes Schröder
Journal: American Journal of Psychiatry (2004)

Although it is well established that cerebral activation increases with higher task load, the potential effects of training have been investigated over brief periods only. Training is of potential clinical relevance since training programs are an essential part of psychiatric therapy.Cerebral activation during a visual spatial working memory task was examined before, during, and after 4 weeks of daily training in nine healthy subjects using functional magnetic resonance imaging.All subjects showed a pronounced activation mainly involving the right inferior frontal gyrus and the right intraparietal sulcus. While the respective regions showed activation increases with improved performance after 2 weeks of training, the activation values decreased at the time of consolidation of performance gains after 4 weeks.Our results suggest that training-related cerebral activation changes follow an inverse U-shaped quadratic function and raise the prospect of investigating cerebral mechanisms underlying training effects.
Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial
Authors: Birgitte B Rasmussen, Meredith M Regan, Anne E Lykkesfeldt, Patrizia Dell'Orto, Barbara Del Curto, Katrine L Henriksen, Mauro G Mastropasqua, Karen N Price, Eliane Méry, Magali Lacroix-Triki, Stephen Braye, Hans J Altermatt, Richard D Gelber, Monica Castiglione-Gertsch, Aron Goldhirsch, Barry A Gusterson, Beat Thürlimann, Alan S Coates, Giuseppe Viale
Journal: The Lancet Oncology (2007)
Cord Blood (CB) Eosinophil/Basophil (Eo/B) Progenitors Predict Respiratory Outcomes Until The Age Of Two
Authors: K.M. Weisse, G. Herberth, S. Roeder, M. Borte, D. Heroux, J.A. Denburg, I. Lehmann
Journal: Journal of Allergy and Clinical Immunology (2012)
Botox party at Johns Hopkins comes under fire
Authors: F. Charatan
Journal: BMJ (2002)

“It's Botox Night at Johns Hopkins,” said the invitation distributed by Hopkins Medicine and sponsored by Dr Patrick Byrne, director of the division of facial, plastic, and reconstructive surgery in the Department of Otolaryngology, Head, and Neck Surgery at Johns Hopkins.

The event, held on 11 July from 5 pm to 7 pm in the outpatient department, promised that anyone “interested in receiving Botox treatments may do …
The effect of mechanical ventilation on oxygen consumption in critically ill patients.
Authors: C A Manthous, J B Hall, R Kushner, G A Schmidt, G Russo, L D Wood
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

We measured oxygen consumption (VO2) during spontaneous breathing with continuous positive airway pressure (CPAP), assist control ventilation (AC), and control ventilation during muscle relaxation (AC-MR) in eight patients undergoing resuscitation from cardiopulmonary failure. VO2 decreased in all eight patients between CPAP and AC-MR; mean VO2 (255 +/- 92 ml/min) on CPAP exceeded that on AC-MR (209 +/- 79 ml/min) (p < 0.005). Compared with CPAP, AC without MR reduced VO2 in five of eight patients and mean VO2 (227 +/- 59 ml/min) tended to decrease (p = 0.14); clinical examination did not distinguish patients requiring MR to reduce VO2 further. If VO2 on CPAP approximates VO2 during spontaneous breathing, the difference between CPAP and AC-MR (VO2resp) represents the decrement of VO2 that can be obtained during muscle rest. Both VO2resp and the mechanical work performed by the ventilator on the respiratory system were increased to about five times the efficiencies reported for normal patients, but VO2resp did not correlate with the mechanical work because of a wide range of respiratory muscle efficiencies. These efficiencies are less than those reported in normal patients, which may reflect the effect of sepsis, acidemia, hypoxia, or other conditions in these patients. We conclude that mechanical ventilation with muscle relaxation reduces VO2 by more than 20%; beyond stabilizing pulmonary gas exchange, these interventions preserve limited O2 delivery (QO2) for other vital organs.
Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding
Authors: Kenneth M. Kessler
Journal: Annals of Internal Medicine (2004)

Letters6 July 2004Managing Patients with Nonvariceal Upper Gastrointestinal BleedingKenneth M. Kessler, MDKenneth M. Kessler, MDFrom University of Miami School of Medicine, Miami, FL 33101.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-1-200407060-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent endoscopy guidelines from the Nonvariceal Upper GI Bleeding Consensus Conference Group (1) illustrate that a single hierarchy of evidence can lead to illogical conclusions. Because endoscopy is supported by level I evidence, it follows that all processes necessary to perform endoscopy equally supported. It is illogical to assign the availability of an endoscopist, support personnel, and the patient (recommendations 1, 2, and 3, respectively) to an inferior position because these recommendations are based on opinion. While opinion may represent the poorest level of experimental evidence, some opinions, for example, those not open to experimental verification ...Reference1. Barkun A, Bardou M, Marshall JK. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2003;139:843-57. [PMID: 14623622] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Kenneth M. Kessler, MDAffiliations: From University of Miami School of Medicine, Miami, FL 33101. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoConsensus Recommendations for Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding Alan Barkun , Marc Bardou , and John K. Marshall , for the Nonvariceal Upper GI Bleeding Consensus Conference Group*Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding Mohammed S. Khuroo and Mehnaaz S. Khuroo Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding Alan Barkun , Marc Bardou , and John K. Marshall Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding Angelo Andriulli , Vito Annese , and Gioacchino Leandro Metrics 6 July 2004Volume 141, Issue 1Page: 79KeywordsEndoscopyEvidence based medicineHemorrhageReasoning ePublished: 6 July 2004 Issue Published: 6 July 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Endosonography-Guided Endoscopic Resection of Duodenal Carcinoid Tumor
Authors: I. Nishimori, M. Morita, S. Sano, J. Kino-Ohsaki, T. Kohsaki, K. Suenaga, Y. Yokoyama, S. Onishi, T. Sugimoto, K. Araki
Journal: Endoscopy (1997)

Endoscopic resection techniques using snare polypectomy with or without submucosal saline injection have also been applied to resect smaller duodenal carcinoid tumors. We report on two patients where endoluminal ultrasound using a small diameter probe was used to visualize the adherence of the carcinoids to the underlying wall layers and the scperating effect of subtumoril saline injection. One patient, in whom a clear separation between the tumor and the underlying tissue after saline injection was visualized, underwent successful endoscopic resection. In the other patient no clear separation could be achieved after saline injection and the patient underwent surgical removal of his tumor; both tumors were 1 cm or less in their maximal diameter.
Acute effects of urocortin 2 on cardiac function and propensity for arrhythmias in an animal model of hypertension‐induced left ventricular hypertrophy and heart failure
Authors: Silvia Meili‐Butz, Katrin Bühler, Dietlinde John, Peter Buser, Wylie W. Vale, Kirk L. Peterson, Marijke Brink, Thomas Dieterle
Journal: European Journal of Heart Failure (2010)
Repression of GAD Autoantigen Expression in Pancreas β-Cells by Delivery of Antisense Plasmid/PEG-g-PLL Complex
Authors: Minhyung Lee, Sang-oh Han, Kyung Soo Ko, Jae Joon Koh, Jong-Sang Park, Ji-Won Yoon, Sung Wan Kim
Journal: Molecular Therapy (2001)

It was previously reported that silencing of the expression of glutamic acid decarboxylase (GAD) in transgenic nonobese diabetic (NOD) mice completely protected islet β-cells against development of diabetes. This suggests that the repression of GAD autoantigen by somatic gene delivery can prevent autoimmune destruction of pancreatic β-cells. To repress GAD expression in islet β-cells, we delivered an antisense GAD mRNA expression plasmid (pRIP-AS-GAD) using poly(ethylene glycol)-grafted poly-L-lysine (PEG-g-PLL) as a gene carrier. In a gel retardation assay, the pRIP-AS-GAD/PEG-g-PLL complex was completely retarded above a weight ratio of 1:1.5 (plasmid: PEG-g-PLL). PEG-g-PLL protected the plasmid DNA from DNase I for more than 60 minutes. In a reporter gene transfection assay, PEG-g-PLL showed the highest transfection efficiency at a weight ratio of 1:3. We also transfected pRIP-AS-GAD/PEG-g-PLL complex into a GAD-producing mouse insulinoma (MIN6) cell line. The antisense mRNA was expressed specifically in β-cells and expression was dependent on glucose level. The repression of GAD after transfection of pRIP-AS-GAD was confirmed by immunoblot assay. In addition, in vivo expression of antisense RNA in pancreas was confirmed by RT-PCR after intravenous injection of the complex into mice. Therefore, our study revealed that the pRIP-AS-GAD/PEG-g-PLL system is applicable for the repression of GAD autoantigen expression.
An Unusual Complication of Laparoscopic Cholecystectomy
Authors: K. A. Hansen, R. Wood
Journal: Endoscopy (1994)

Laparoscopic cholecystectomy is gaining increasing acceptance as a mode of minimally invasive surgery. We describe a peculiar gynecologic complication following uncomplicated laparoscopic cholecystectomy. Our patient presented with a four-month history of subacute pelvic pain, primarily located in the right lower quadrant, two years after laparoscopic cholecystectomy. Diagnostic laparoscopy revealed a hemaclip embedded in the right ovarian capsule of an otherwise normal pelvis. The hemaclip had probably dislodged from its original site of placement in the upper abdomen, and migrated to the dependent portions of the pelvis, where it implanted in a follicular stigma and became affixed to the ovarian capsule. The hemaclip was removed without complications, and the patient's symptoms improved.
Allogeneic Stem-Cell Transplantation From Related and Unrelated Donors in Older Patients With Myeloid Leukemia
Authors: Hartmut Bertz, Karin Potthoff, Jürgen Finke
Journal: Journal of Clinical Oncology (2003)

Purpose: To improve outcome for older patients with poor-prognosis myeloid malignancies by using allogeneic hematopoietic stem-cell transplantation (alloHSCT) from unrelated and sibling donors after reduced-intensity conditioning (RIC). Patients and Methods: Nineteen older patients (median age, 64 years; range, 60 to 70 years) with active myeloid malignancies were treated with an RIC regimen that was based on fludarabine, melphalan, and carmustine followed by alloHSCT from matched unrelated (n = 12) or sibling donors (n = 7). Before transplantation, patients had a median of 50% bone marrow blasts (range, 0% to 70%). Graft-versus-host-disease (GvHD) prophylaxis consisted of cyclosporine and mycophenolate mofetil or methotrexate. Eleven of 12 patients with an unrelated donor also received anti–T-lymphocyte globulin (ATG). Results: Engraftment was successful for all 19 patients. Seventeen assessable patients achieved complete response (CR). Four patients experienced relapse; three achieved CR again after donor lymphocyte infusion (n = 1) or a second alloHSCT (n = 2). Six patients died as a result of relapse (n = 2), GvHD-associated complications (n = 2), or fungal infections (n = 2), resulting in a 1-year nonrelapse mortality rate of 22%. With a median follow-up of 825 days (range, 595 to 1,028 days), 13 of 19 patients are alive, resulting in a 1-year survival rate of 68% (95% confidence interval, 48% to 89%). Conclusion: In older patients with untreated poor-prognosis leukemia, this RIC regimen combined with alloHSCT sufficiently reduces the leukemic burden, resulting in a high CR rate. When ATG is added, matched unrelated donor transplantation can be performed safely in older patients. For these patients, early transplantation after diagnosis offers a fair chance of cure.
Comment: Operate and/or Irradiate?
Authors: Philip Rubin
Journal: JAMA (1972)

Before 1950, when radiation doses ranged from 150 to 400 kv, combining surgery and radiotherapy was always done cautiously. Large doses of such quality of irradiation led to late changes in connective tissues and vessels. It was reasoned that preoperative irradiation sclerosed blood and lymph vessels, so that as the tumor regressed, the surgeon would not only have a safer margin, but would not be as likely to disseminate the cancer during surgery. When irradiation was given in the immediate postoperative period, it eradicated foci of microscopic cancer cells or entrapped them in a fibrotic scar so they could not spread. The initial concern in combining both methods was that it might lead to so great a chance of morbidity that it could offset the gain in tumor control. Routine use of preoperative or postoperative irradiation in head and neck cancers was rare. Thinking changed in the 1950s for two
Upper limit of vulnerability reliably predicts the defibrillation threshold in humans.
Authors: C Hwang, C D Swerdlow, R M Kass, E S Gang, W J Mandel, C T Peter, P S Chen
Journal: Circulation (1994)

BACKGROUND The upper limit of vulnerability is the stimulus strength above which electrical stimulation cannot induce ventricular fibrillation even when the stimulus occurs during the vulnerable period of the cardiac cycle. The purpose of this study was to test the hypothesis that the upper limit of vulnerability can accurately predict the defibrillation threshold in patients undergoing implantable cardioverter-defibrillator (ICD) implantation using nonthoracotomy lead systems. METHODS AND RESULTS We studied 77 patients at the time of ICD implantation. Multiple endocardial-endocardial and endocardial-subcutaneous shock pathways were used. Two different protocols were used to test the upper limit of vulnerability. In protocol 1 (n = 17), the upper limit of vulnerability was tested with two shocks on the peak or the up-slope of the T wave of paced rhythm. The shocks were given randomly either at the peak and 20 milliseconds before the peak of T wave (n = 7) or at 20 and 40 milliseconds before the peak of T wave (n = 10). In protocol 2 (n = 60), the upper limit of vulnerability was tested with three shocks delivered at 0, 20, and 40 milliseconds before the peak of the T wave. The weakest shock that failed to induce ventricular fibrillation by a 5-J step-down or step-up method was defined as the upper limit of vulnerability. The defibrillation threshold was also determined by a 5-J step-down or step-up method. In protocol 1, the upper limit of vulnerability (9 +/- 6 J) was significantly lower than the defibrillation threshold (13 +/- 7 J) with a correlation coefficient of .87 and P &lt; .001. In protocol 2, the upper limit of vulnerability (13 +/- 6 J) was not significantly different from the defibrillation threshold (13 +/- 6 J) with a correlation coefficient of .85 and P &lt; .001. In 45 of the 60 patients, the upper limit of vulnerability was &lt; or = 15 J; all had a defibrillation threshold of &lt; or = 20 J. In 51 of the 60 patients, the upper limit of vulnerability was within 5 J of the defibrillation threshold. The upper limit of vulnerability overestimated the defibrillation threshold by &gt; 10 J in 8 patients and underestimated the defibrillation threshold by &gt; 10 J in only 1 patient. The overestimation and underestimation occurred only in patients with the upper limit of vulnerability &gt; 15 J. CONCLUSIONS When tested with three shocks on and before the peak of the T wave, the upper limit of vulnerability accurately predicted the defibrillation threshold in patients undergoing ICD implantation using nonthoracotomy lead systems. This method required either one or no episodes of ventricular fibrillation in most patients.