tbuckley/cabot-search huggingface dataset:
Denial in Heart Transplant Candidates
Authors: Laurens D. Young, Jan Schweiger, Jan Beitzinger, Robert McManus, Carolyn Bloedel, J. Koob
Journal: Psychotherapy and Psychosomatics (1991)

The concept of denial is important for the psychosomatic understanding of cardiovascular disease and treatment. This study evaluated denial using several psychometric assessment scales in patients referred for psychiatric evaluations prior to heart transplantation. Surviving patients who had a mean survival of more than 38 months had less denial than nonsurviving patients who had a mean survival of 4 months. These findings are very preliminary, but interesting, and would encourage further investigation of denial in these patients. Denial is a complex psychological variable, only part of which may be applicable to surgery patients.
An alcoholic patient who continues to drink: case progression
Authors: Stuart McPherson, Colin John Rees
Journal: BMJ (2006)

Last week (7 January, BMJ 2006;332: 33), we described the case of Mr Bond, who has alcoholic liver disease and presented with haematemesis. The key to his initial management was resuscitation. He was tachycardic, which may partly have been due to alcohol withdrawal and agitation but probably suggested a haemodynamic response to a clinically important bleed. His heart rate was notably raised given that he was taking β blockers.

Mr Bond was stabilised in the accident and emergency department with aggressive fluid resuscitation through large bore cannulas. Blood was cross-matched, and he was given intravenous vitamin K and tranexamic acid to correct his clotting abnormalities. After resuscitation Mr Bond had gastroscopy to establish the cause of …
Retraction: Article on Estrogen Receptor β in Ovarian Carcinogenesis
Authors: Gwendal Lazennec
Journal: Cancer Research (2005)

Upon closer review of our article on estrogen receptor β in ovarian carcinogenesis, published in the [August 15, 2004][1], issue of Cancer Research ([1][2]), we have discovered that some of the data were manipulated. The first author of the article has admitted altering data records. Because these
CONGENITAL COXA VARA.
Authors: HENRY O. FEISS
Journal: JAMA (1906)

E. S., 3-year-old girl, a patient of Dr. O. T. Maynard's of Elyria, was referred to Dr. E. F. Cushing, who kindly referred her to me Oct. 10, 1905. <h3>History.</h3> —The family history showed nothing of importance. The mother was well developed and healthy and had several other normal children. Pregnancy was normal. The birth ran smoothly, but at delivery Dr. Maynard noticed that the legs were in a peculiar position. The right one was flexed with the knee pointing outward in the normal way and the lower leg placed across the abdomen, but the left leg, instead of being in a position symmetrical to the right, had its thigh adducted into approximation with the right thigh. The knee was sharply flexed and the lower leg ran parallel to the lower leg of the right side, the foot being turned outward at the ankle. This position having been noted, the
Comparison of Planar, SPECT, and 3-D Synthetic Reprojection Images A Case Study
Authors: L STEVEN BUJENOVIC, J. RANDOLPH PERRY, WILLIAM H. McCARTNEY
Journal: Clinical Nuclear Medicine (1995)

A case study is presented in which three types of images from a Ga-67 study are compared. The Ga-67 study was performed on a patient with fever of unknown origin (FUO). Planar and SPECT images were obtained. Planar data were presented as standard 2-D images on radiographic film. The SPECT data were used to generate two sets of images: standard 2-D multiple 'slice' images presented on radiographic film and a rotating 3-D synthetic reprojection displayed on a computer monitor. Compared to the planar and SPECT images, three sites of inflammation and the path of an oblique sinus tract were best seen in the 3-D synthetic reprojection. Recognition of anatomic structures and their spatial relationships was most readily apparent when viewing the 3-D synthetic reprojection, and this method of display facilitated the rapid recognition of abnormal findings.
In-Patient and Ward Psychosomatic Psychotherapy: Concepts, Effectiveness and Curative Factors
Authors: Bernhard Strauss, Manuela Burgmeier-Lohse
Journal: Psychotherapy and Psychosomatics (1993)

Based on the situation in the Federal Republic of Germany, this article reviews the development, organization and theoretical framework of in-patient and ward psychosomatic psychotherapy. Indications for treating psychosomatic patients in hospital, the effects of treatment and some results on the process of in-patient psychotherapy are summarized. Some of the specific features of in-patient and ward psychotherapy are adopted as components for a theoretical model of in-patient psychotherapy. Our experience with this form of therapy suggests that it can play an important role within the care system, is a fruitful field for training psychotherapists and acts as an excellent model for further research into psychotherapy.
Chloroquine-Induced Hair Hypopigmentation
Authors: Jeff C Donovan, Vera H Price
Journal: New England Journal of Medicine (2010)

A 16-year-old, blonde-haired patient was evaluated for a new band of lighter-colored hair located approximately 3 cm from the scalp. The patient first noted the change in hair color 1 week after returning from a 2-week vacation in Costa Rica, during which she took chloroquine phosphate for malaria prophylaxis. Instead of taking 500 mg weekly, the recommended dose for prophylaxis, the patient took 500 mg of chloroquine phosphate daily, starting 1 week before the trip, during the 2 weeks in Costa Rica, and for 1 week after returning home. She had taken the first dose 3.5 months before presentation. Hair . . .
Delayed Cutaneous Hypersensitivity Reactions to Autologous Extracts of Burkitt-Lymphoma Cells
Authors: Leroy Fass, Ronald B. Herberman, John Ziegler
Journal: New England Journal of Medicine (1970)

Investigations were performed to determine whether patients with Burkitt's lymphoma have delayed hypersensitivity reactions to antigens on the autologous tumor cells. Twelve patients were skin tested two to four days after initial biopsy. Only one patient, with a localized jaw tumor, had a positive reaction to autologous tumor extract, and none reacted to autologous lymphocyte extract. Eight of these patients were retested after treatment, and four additional patients were tested for the first time, when in clinical remission; seven of the 12 had positive reactions to autologous tumor extract. All seven remained in sustained clinical remission, for a median of 31 weeks after therapy. Four of the patients with negative reactions relapsed 14 to 20 weeks after therapy. The results indicate that many patients with Burkitt's lymphoma have delayed hypersensitivity responses to autologous tumor antigens and that positive reactions are correlated with sustained remission.
O8.04 * TEMOZOLOMIDE AFTER RADIOTHERAPY IN RECURRENT "LOW-GRADE" DIFFUSE BRAINSTEM GLIOMA IN ADULTS
Authors: G. Reyes-Botero, F. Laigle-Donadey, K. Mokhtari, N. Martin-Duverneuil, J. Y. Delattre
Journal: Neuro-Oncology (2014)

INTRODUCTION: Diffuse brainstem glioma is a rare disease in adults. Radiotherapy (RT) is frequently used as initial treatment. However, only limited data is available concerning chemotherapy efficacy at relapse after RT. Temozolomide (TMZ) is frequently used in progressive supratentorial gliomas after RT, but its efficacy in diffuse brainstem gliomas in adults has not been reported. PATIENTS AND METHODS: We conducted a retrospective analysis including patients from our database with non-enhancing diffuse brainstem glioma (histological or MRI criteria compatible with low-grade glioma) who received TMZ at relapse after RT. Tumors localized in the pons, medulla oblongata or midbrain were analyzed excluding supratentorial or infratentorial tumors secondary infiltrating the brainstem. Clinical and radiological responses were assessed and progression-free survival (PFS) and overall survival (OS) time were estimated. RESULTS: In total, 15 adult patients (median age 34 years) were selected. Histological analysis was available in 5 cases showing grade II oligodendroglioma (2 cases), grade II oligoastrocytoma (2 cases), grade II astrocytoma (1 case). Ten patients were selected by MRI criteria only. All patients received RT as initial treatment obtaining a median PFS of 34.2 months (95% CI 24.1-44.2). Median KPS at the time of relapse after RT was 80. TMZ was administered orally at 150-200mg/m2 for 5 days every 28 days at progression disease after RT. Clinical improvement after TMZ was observed in 9 cases (60%) whereas radiological assessment detected 6 partial responses. Estimated median PFS after TMZ was 9.5 months (95% CI 7.9-11) and median OS was 14.4 months (95% CI 10.5-18.2). Grade 3 thrombocytopenia was observed in 26% of cases. CONCLUSIONS: TMZ could be useful in adult patients with progressive diffuse low-grade brainstem glioma after RT failure. Further studies are warranted to detect clinical and biological markers of response to TMZ.
Osteogenic differentiation of rat bone marrow stromal cells cultured on Arg–Gly–Asp modified hydrogels without dexamethasone and β-glycerol phosphate
Authors: Heungsoo Shin, Johnna S. Temenoff, Gregory C. Bowden, Kyriacos Zygourakis, Mary C. Farach-Carson, Michael J. Yaszemski, Antonios G. Mikos
Journal: Biomaterials (2004)
Immunotherapy With Transfer Factor
Authors: Charles H. Kirkpatrick
Journal: JAMA (1977)

Several years ago, H. Sherwood Lawrence, MD, reported that it was possible to transfer delayed-type skin reactivity from sensitive human donors to unreactive recipients, with materials from disrupted blood leukocytes. This finding was in sharp contrast to the previous observations in guinea pigs in which there was an obligatory requirement for living lymphoid cells for achievement of passive transfer. The longevity of the passively acquired reactivity was also different. In guinea pigs, the transferred reactivities were lost within a few days unless inbred animals were used; in man, the state of hypersensitivity lasted for many months, even when allogeneic relationships existed between the donors and recipients. The component of the lysates that was responsible for this activity was designated "transfer factor." For several years, transfer factor rested as an immunologic curiosity. Little was known about its composition or mechanism of action. Attempts to investigate the phenomenon of transfer of delayed
Woman asks court for peaceful death
Authors: C. Dyer
Journal: BMJ (1997)

A woman suffering from motor neurone disease is to ask the High Court for the right to end her life peacefully in the first case of its kind in Britain.

Annie Lindsell, aged 47, wants to die at home and is seeking a guarantee that her GP will lawfully be able to administer enough morphine to ease her distress, even though the dose may be fatal. Her lawyers emphasise that she is not asking for voluntary euthanasia, which is unlawful, but relying on the doctrine of double effect, under which a doctor may administer a drug …
ELECTROCARDIOGRAPHIC CHANGES CONSISTENT WITH ATRIAL INFARCTION IS A POTENTIAL INDEPENDENT PREDICTOR OF 30 DAY AND 1 YEAR MORTALITY IN PATIENTS WITH ACUTE ST-ELEVATION MYOCARDIAL INFARCTION
Authors: Marvin Louis Roy Yap Lu, Chinualumogu Nwakile, Mahek Shah, Toni Anne De Venecia, Vincent Figueredo
Journal: Journal of the American College of Cardiology (2015)
Abstract 3685: C-Jun modulates alcohol-induced RNA Pol III-dependent transcription through Brf1 and TBP pathway
Authors: Qingsong Zhang, Austin G. Evans, Daniel Levy, Shuping Zhong
Journal: Cancer Research (2011)

Abstract Cancer cells have a consistent cytological feature of nucleolar hypertrophy, enlarged nucleoli, where RNA polymerase III genes (Pol III genes) are transcripted. This implies that transformation in situ is closely linked to the deregulation of Pol III gene transcription, because the size of the nucleolus reflects the levels of rRNA synthesis. Deregulation of Pol III genes is tightly associated cell transformation and tumorgenesis. However, very little is known about whether alcohol consumption affects Pol III gene transcription. By using cell culture model and animal model, we have found, for the first time that alcohol induces Pol III gene transcription in JNK1 and ADH dependent manner. Alcohol increases c-Jun expression in HepG2-ADH cells. To determine whether the alcohol-mediated increases c-jun required to stimulate TBP and Brf1 expression are due to enhance occupancy of c-jun at their promoters, chromatin immunoprecipitation (ChIP) assays were performed. Ethanol induces a marked increase in the recruitment of c-jun to the TBP promoter, while a modest increase in the occupancy of both c-fos and Elk-1 was observed. These results support the idea that alcohol mediates an increase in TBP expression primarily through enhanced expression of c-jun and its recruitment to the TBP promoter. Sequence analysis reveals both putative AP-1 and Elk-1 binding sites in regions 5’ of the transcription start site of the Brf1 gene. ChIP analysis reveals that ethanol induces an increase in the occupancy of c-jun to the region containing an AP-1 binding site, while no significant increase in binding of Elk-1 to the Elk-1 binding site is observed. Interestingly, c-jun, c-fos and Elk-1 are also found to occupy the tRNALeu gene. Upon ethanol treatment, an increase in TBP recruitment to the tRNALeu gene is observed, as well as a marked increase in the occupancy of c-jun. However, alcohol does not induce any apparent change in recruitment of either c-fos or Elk-1 to the tRNA gene. These results suggest that c-jun may function directly at sequences near tRNA genes to induce transcription. Together, these results support the idea that alcohol enhances expression of TBP, Brf1, and tRNA gene by facilitating c-jun recruitment to these promoters. *: This project was supported by NIH grant AA017288 to S.Z. **: Corresponding author: szhong@usc.edu. Tel: 626-628-7693 or 323-442-114 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3685. doi:10.1158/1538-7445.AM2011-3685
Effects of mechano-electrical feedback: potential arrhythmogenic influence in patients with congestive heart failure
Authors: M. J. Reiter
Journal: Cardiovascular Research (1996)

Experimental studies have demonstrated that changes in mechanical loading conditions have important, and potentially arrhythmogenic, electrophysiologic effects. These studies have, for the most part, involved the effects of acute dilatation in the structurally normal heart. The ionic basis of these changes remains incompletely understood. Although there is abundant evidence that mechano-electrical feedback occurs in man, additional studies are required to clarify whether the mechanical and hemodynamic abnormalities present in patients with congestive heart failure are a significant contributor to the clinical arrhythmias in these patients. Ongoing studies should clarify this important issue.
Aberrant p53 Expression Correlates With Expression of Vascular Endothelial Growth Factor mRNA and Interleukin-8 mRNA and Neoangiogenesis in Non-Small-Cell Lung Cancer
Authors: A. Yuan
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To evaluate interactions between expressions of tumor suppressor gene p53 and angiogenic factors vascular endothelial cell growth factor (VEGF) and interleukin-8 (IL-8) and their effect on tumor angiogenesis and patient prognosis in non–small-cell lung cancer (NSCLC). PATIENTS AND METHODS: p53, VEGF, IL-8, and the microvessel endothelium were immunostained, and VEGF and IL-8 mRNA expression were quantified using the real-time quantitative reverse-transcription polymerase chain reaction in 65 NSCLC surgical specimens. Aberrant p53 expression was correlated with VEGF and IL-8 mRNA expression, microvessel count (MVC), other clinical-pathologic variables, and patients’ survival. RESULTS: Tumors with high aberrant p53 expression showed significantly higher VEGF and IL-8 mRNA expression and MVC than those with low aberrant p53 expression (P < .001). When tested as a continuous variable, aberrant p53 expression correlated strongly and positively with VEGF and IL-8 mRNA expression and MVC (P < .0001). Tu...
Retrospective Diagnosis by Serologic Means of Congenitally Acquired Rubella Infections
Authors: Thomas H. Weller, Charles A. Alford, Franklin A. Neva
Journal: New England Journal of Medicine (1964)

THE teratogenic potential of rubella virus has been the subject of continuing assessment since Gregg1 established a causal relation between maternal rubella and the occurrence of congenital cataracts and congenital heart disease. Shortly thereafter deafness was reported as a feature of the syndrome of congenital rubella, and more refined studies have recently indicated that lesser degrees of impairment of hearing in children are a common consequence of rubella during the first sixteen weeks of pregnancy.2 Rubella has also been incriminated as an etiologic factor in abortions and stillbirths, in prematurity and in physical and mental retardation, as well as in . . .
Unique vascular morphology of the fourth aortic arches: possible implications for pathogenesis of type-B aortic arch interruption and anomalous right subclavian artery
Authors: M Bergwerff
Journal: Cardiovascular Research (1999)

Objective: Neural crest-derived cells were previously shown to participate in vessel wall formation of the great thoracic arteries, and their contribution was proposed to affect morphology and physiology of these vessels in the chick. The present investigation was undertaken to examine vascular differentiation and morphogenesis of the neural crest-derived aortic arches in mammals. Methods: Using immunohistochemical markers for smooth muscle cell differentiation and a neurofilament marker, we examined morphogenesis of the great arteries in mice, ranging from embryonic day 11.5 to the adult. Results: We observed that in the 4th aortic arch arteries early media formation differed from the other arteries, in that they almost completely lacked (or showed decreased) actin expression in certain areas. This discontinuity in actin expression persisted throughout much of foetal development, in the form of circular segments of cells displaying decreased staining for smooth muscle markers, both at the left and right side of the arterial tree. In adult mice, the 4th arch artery derivatives, segment B of the aortic arch and the proximal right subclavian artery, were observed to differ from adjoining vessels in their smooth muscle and elastic composition. Staining for neurofilaments revealed close association of the developing segments with apparent sensory afferent vascular innervation. Conclusion: The unique areas of the 4th arch artery identified here reflect the basic segmental patterning of the early embryonic pharyngeal arches. These segments correlate with sites that are predisposed to interruption or severe hypoplasia, and may thus reveal part of the aetiology of type-B aortic arch interruptions and arteria lusoria.
Comparison of Steroid and Combined Steroid-lmmunosuppressive Treatment of Lupus Erythematosus Nephritis.
Authors: N. M. Simon
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Comparison of Steroid and Combined Steroid-lmmunosuppressive Treatment of Lupus Erythematosus Nephritis.N. M. Simon, M.D., F.A.C.P., W. J. Werner, M.D., W. A. Franklin, M.D., E. V. Potter, M.D.N. M. Simon, M.D., F.A.C.P.Search for more papers by this author, W. J. Werner, M.D.Search for more papers by this author, W. A. Franklin, M.D.Search for more papers by this author, E. V. Potter, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-842_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwenty-two patients with lupus erythematosus (LE) nephritis were treated with steroids or a combined steroid-immunosuppressive regimen, or both. On 15 occasions steroids were given alone, usually in doses greater than 40 mg/day of prednisone for prolonged periods; on 10 occasions steroids were combined with azathioprine or chlorambucil in doses of 2 to 3 mg/kg body weight/day or 6 to 8 mg/day, respectively, and were reduced in dosage when active disease was controlled. The duration of observation after treatment ranged from 1 to 101 months, with a median of 14 months. Renal tissue was obtained for light microscopic examination in all... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: N. M. Simon, M.D., F.A.C.P.; W. J. Werner, M.D.; W. A. Franklin, M.D.; E. V. Potter, M.D.Affiliations: Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical pathologic conference 1 May 1971Volume 74, Issue 5Page: 842-842KeywordsLupus erythematosusNephritis ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
Dietetic Food Diarrhea
Authors: Mario J. R. Ravry
Journal: JAMA (1980)

THE HEXITOLS, a group of sugar alcohols that are acted on slowly by bacteria in the oral cavity and are slowly absorbed from the gastrointestinal tract, are capable of inducing osmotic diarrhea.<sup>1-4</sup>Sorbitol and mannitol, the best known of the hexitols, are key ingredients in many "sugarfree" foodstuffs used as weight reduction aids and to help prevent dental caries. Although Gryboski<sup>2</sup>described the occurrence of diarrhea in children consuming dietetic candy in 1966, it was not until 1978 that the subject was revived by the report of "chewing gum diarrhea" in an adult.<sup>3</sup>The following case is presented to create awareness of the phenomenon and to demonstrate that it may be induced not only by chewing gum but also by other dietetic foodstuffs. <h3>Report of a Case</h3> A 29-year-old healthy man had diarrhea of two weeks' duration. Attempting to reduce weight by dieting, he found it difficult
Immunolocalisation of type VI collagen in the intervertebral disc.
Authors: S Roberts, S Ayad, P J Menage
Journal: Annals of the Rheumatic Diseases (1991)

Type VI collagen has been isolated from many connective tissues, including the intervertebral disc. Distribution of this collagen, however, varies considerably within different tissues. In adult mammalian nasal and articular cartilage it is localised preferentially in the matrix immediately surrounding the cell. Intervertebral discs from various species and of various ages were studied and a similar pericellular localisation was found. When antisera to type VI collagen were used staining was seen around the cells of all sections of intervertebral disc, being particularly prominent in the nucleus pulposus. Staining on or around the cells was also seen in the adjacent cartilaginous end plate and bone.