tbuckley/cabot-search huggingface dataset:
Aspirin and Postoperative Bleeding
Authors: RICHARD S. STEIN
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 January 1979Aspirin and Postoperative BleedingRICHARD S. STEIN, M.D.RICHARD S. STEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-123_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Torosian and colleagues (1) have reported increased postoperative bleeding in patients receiving aspirin within a week of surgery. Although the effects of aspirin last for the lifetime of exposed platelets, 5 to 7 days, the bleeding time is normal within 2 days after administration of aspirin (2, 3), and platelets collected from donors receiving aspirin 36 h before donation can correct abnormal bleeding times in recipients (4). Although aspirin-exposed platelets do not release their own ADP, if sufficient normal platelets are present the entire platelet pool appears to function normally, at least as measured by bleeding time....References1. TOROSIANMICHELSONMORGANROTHMACVAUGH MEJH: Aspirin- and Coumadin®-related bleeding after coronary-artery bypass graft surgery. Ann Intern Med 89:325-328, 1978 LinkGoogle Scholar2. HIRSHSTREETCADOAMY JDJH: Relation between bleeding time and platelet connective tissue reaction after aspirin. Blood 41:369-377, 1973 CrossrefMedlineGoogle Scholar3. STUARTMURPHYOSKIEVANSDONALDSONGARDNER MSFAMF: Platelet function in recipients of platelets from donors ingesting aspirin. N Engl J Med 287:1105-1109, 1972 CrossrefMedlineGoogle Scholar4. O'BRIEN J: Effects of salicylates on human platelets. Lancet 1:779-783, 1968 CrossrefMedlineGoogle Scholar1. TOROSIANMICHELSONMORGANROTHMACVAUGH MEJH: Aspirin- and Coumadin®-related bleeding after coronary-artery bypass graft surgery. Ann Intern Med 89:325-328, 1978 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD S. STEIN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1979Volume 90, Issue 1Page: 123-123KeywordsAdenosine diphosphateAspirinHemorrhagePlateletsSurgery ePublished: 1 December 2008 Issue Published: 1 January 1979 PDF downloadLoading ...
CXCR3 Ligands Are Associated with the Continuum of Diffuse Alveolar Damage to Chronic Lung Allograft Dysfunction
Authors: Michael Y. Shino, S. Samuel Weigt, Ning Li, Vyacheslav Palchevskiy, Ariss Derhovanessian, Rajan Saggar, David M. Sayah, Aric L. Gregson, Michael C. Fishbein, Abbas Ardehali, David J. Ross, Joseph P. Lynch, Robert M. Elashoff, John A. Belperio
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Rationale: After lung transplantation, insults to the allograft generally result in one of four histopathologic patterns of injury: (1) acute rejection, (2) lymphocytic bronchiolitis, (3) organizing pneumonia, and (4) diffuse alveolar damage (DAD). We hypothesized that DAD, the most severe form of acute lung injury, would lead to the highest risk of chronic lung allograft dysfunction (CLAD) and that a type I immune response would mediate this process.Objectives: Determine whether DAD is associated with CLAD and explore the potential role of CXCR3/ligand biology.Methods: Transbronchial biopsies from all lung transplant recipients were reviewed. The association between the four injury patterns and subsequent outcomes were evaluated using proportional hazards models with time-dependent covariates. Bronchoalveolar lavage (BAL) concentrations of the CXCR3 ligands (CXCL9/MIG, CXCL10/IP10, and CXCL11/ITAC) were compared between allograft injury patterns and "healthy" biopsies using linear mixed-effects models. The effect of these chemokine alterations on CLAD risk was assessed using Cox models with serial BAL measurements as time-dependent covariates.Measurements and Main Results: There were 1,585 biopsies from 441 recipients with 62 episodes of DAD. An episode of DAD was associated with increased risk of CLAD (hazard ratio, 3.0; 95% confidence interval, 1.9–4.7) and death (hazard ratio, 2.3; 95% confidence interval, 1.7–3.0). There were marked elevations in BAL CXCR3 ligand concentrations during DAD. Furthermore, prolonged elevation of these chemokines in serial BAL fluid measurements predicted the development of CLAD.Conclusions: DAD is associated with marked increases in the risk of CLAD and death after lung transplantation. This association may be mediated in part by an aberrant type I immune response involving CXCR3/ligands.
Pensions and the Abatement Rule
Authors: V. Purvis
Journal: BMJ (1971)

glucose was measured sequentially, blood glucose remained below 20 mg/100 ml for longer than 24 hours.Furthermore, a hypo- glycaemic baby may develop symptoms after many hours of being asymptomatic.This occurred in an infant, seen some years ago, who had a blood glucose level of 15 mg/100 ml at 10 hours of age.He was asymptomatic and was not treated.The glucose level re- mained low until, at 75 hours of age, he had a convulsion which responded to intravenous
Adenovirus-Mediated Gene Transfer Reconstitutes Depressed Sarcoplasmic Reticulum Ca <sup>2+</sup> -ATPase Levels and Shortens Prolonged Cardiac Myocyte Ca <sup>2+</sup> Transients
Authors: Frank J. Giordano, Huaping He, Patrick McDonough, Markus Meyer, M. Richard Sayen, Wolfgang H. Dillmann
Journal: Circulation (1997)

Background Decreased expression of the sarcoplasmic reticulum (SR) Ca 2+ -ATPase of the cardiac myocyte (SERCA2) and abnormal Ca 2+ regulation have been independently linked to human heart failure. This study was designed to determine whether expression of a SERCA2 transgene could reconstitute depressed cardiac myocyte SERCA2 levels, augment SR Ca 2+ uptake, and shorten prolonged excitation-contraction (EC)–associated Ca 2+ transients in neonatal rat cardiac myocytes (NM). Methods and Results Cultured NM were treated with phorbol-12-myristate-13-acetate (PMA), a compound that decreases endogenous SERCA2 expression and results in prolongation of EC-associated Ca 2+ transients. PMA-treated NM had a 75% reduction in SERCA2 mRNA and a 40% reduction in SERCA2 protein levels. SERCA2 adenovirus infection increased SERCA2 mRNA expression to 2.5 times control and reconstituted SERCA2 protein levels in PMA-treated cells. This reconstitution was associated with a 32.4% reduction in the time for decline of the Indo-1 Ca 2+ transient to half-maximum levels ( t 1/2 [Ca 2+ ] i ) ( P &lt;.05). A 34.5% augmentation of oxalate-facilitated SR Ca 2+ uptake was also documented in SERCA2 adenovirus–infected cells ( P &lt;.05). Conclusions Adenovirus-mediated expression of a SERCA2 transgene can reconstitute depressed endogenous SERCA2 levels, shorten prolonged Ca 2+ transients, and augment SR Ca 2+ uptake. It is conceivable that such an approach might be used in vivo to normalize altered Ca 2+ regulation in human heart failure.
Non-gonococcal Urethritis
Authors: T. E. Osmond
Journal: BMJ (1950)

A newborn infant presenting with a divided congenital melanocytic naevus of the eyelid is described. Because of the severe disfigurement, risk of later malignant change in the lesion, and the possibility of deprivation amblyopia, early surgical treatment is recommended for all medium and large congenital melanocytic naevi of the eyelid. Surgery in the first few months of life gives the best cosmetic results.
Penicillin in the Treatment of Streptococcal Infections
Authors: B. B. Breese, F. A. Disney
Journal: New England Journal of Medicine (1958)

PENICILLIN is generally conceded to be the drug of choice for treatment of infections due to the beta-hemolytic streptococcus. However, which is the best route of administration and which is the most satisfactory of the many oral preparations are two of the unsolved problems of treatment. This study was designed to answer these questions, at least in part, by comparing one form of long acting penicillin given intramuscularly with five oral penicillin preparations.This is an extension of the study carried out by us in 1955.1 Mohler et al.2 did a similar study in Boston in the same year. In . . .
ADDRESS IN OBSTETRICS AND DISEASES OF WOMEN.
Authors: THAD. A. REAMY
Journal: JAMA (1884)

[Read in General Session of the American Medical Association, May, 1884.] Fellow Members:—Custom, as well as law, prescribes as one of the duties of the Chairman of a Section that he present in his annual address a digest of the progress made in that special department during the past year. Compliance with the letter of this law is now unnecessary, and would, therefore, be unprofitable. Medical journals, general and special, both home and foreign, conducted with great ability and exhibiting much energy and zeal in collecting and publishing the latest advances in all departments, are promptly placed by rapid mail facilities upon the table of every reading member of the profession. Moreover, the editorial criticisms of new doctrines, discoveries, methods or operations, are generally from the pens of those who, by education and special training, have superior abilities for such work. It is, therefore, deemed appropriate, on the present occasion
Accountable Care Organizations and Health Care Disparities
Authors: Craig Evan Pollack, Katrina Armstrong
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TREATMENT OF STRANGULATED HERNIA.Read in the Section on Surgery and Anatomy at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: JOSEPH RANSOHOFF
Journal: JAMA (1894)

"If you see a strangulated hernia in the day, reduce it before the fall of night; if in the night, let not the rising sun witness its presence."—<i>Stromeyer</i>. It is almost a truism that a strangulated hernia, if unrelieved, means death. In an experience of seventeen years, I have seen, with Dr. Richards, one case of umbilical hernia recover without operation after the formation of an artificial anus. It is almost equally true that if the strangulation is relieved early, recovery is the rule that ought to admit of few if any exceptions. The fatal cases of to-day are those of septic peritonitis, of gangrene, of contusion, paresis, and in the aged, pneumonia. With the possible exception of the last named, these fatal conditions are directly ascribable to delay in interference. Fortunately this must be oftenest charged to the neglect of the patient, but the cases are not a few
Fighting Cancer with Vaccinia Virus: Teaching New Tricks to an Old Dog
Authors: Yuqiao Shen, John Nemunaitis
Journal: Molecular Therapy (2004)

Vaccinia virus has played a huge part in human beings' victory over smallpox. With smallpox being eradicated and large-scale vaccination stopped worldwide, vaccinia has assumed a new role in our fight against another serious threat to human health: cancer. Recent advances in molecular biology, virology, immunology, and cancer genetics have led to the design of novel cancer therapeutics based on vaccinia virus backbones. With the ability to infect efficiently a wide range of host cells, a genome that can accommodate large DNA inserts and express multiple genes, high immunogenicity, and cytoplasmic replication without the possibility of chromosomal integration, vaccinia virus has become the platform of many exploratory approaches to treat cancer. Vaccinia virus has been used as (1) a delivery vehicle for anti-cancer transgenes, (2) a vaccine carrier for tumor-associated antigens and immunoregulatory molecules in cancer immunotherapy, and (3) an oncolytic agent that selectively replicates in and lyses cancer cells.
BRIDGING THE DISCHARGE GAP EFFECTIVELY (BRIDGE): FOLLOW-UP RESULTS ON THE EFFECT OF THE BRIDGE CLINIC TRANSITIONAL CARE MODEL ON PREVENTING EARLY READMISSIONS AND ED VISITS -6 MONTH OUTCOMES
Authors: Redah Zainub Mahmood, Sherry Bumpus, Cydni Smith, Sangeetha Krishnan, Janice Norville, Eva Kline-Rogers, James Froehlich, Kim Eagle, Melvyn Rubenfire
Journal: Journal of the American College of Cardiology (2012)
CONSTRUCTION OF AN ARTIFICIAL PATELLA
Authors: F. J. Lennon
Journal: JAMA (1928)

Ankylosis of a joint, particularly of the shoulder, elbow, hip and knee, so seriously handicaps the manual worker that every effort should be made to remedy this defect. The employer today is reluctant to hire a man who is physically disabled, and hence surgeons have been called on to exercise their ingenuity in devising means to increase the range of motion and to limit the pain in diseased joints. Gallie and LeMesurier<sup>1</sup>have demonstrated the many ways in which fascia lata may be used in plastic and reconstruction surgery. They chose this tissue because of its accessibility and its resistance under strain and particularly because it was not absorbed. Their notable experiments on the repair of hernias and of large defects in the abdominal wall following gunshot and shrapnel wounds were convincing evidence of the value of this procedure. Since that time, this method has been used by many
Comparison between interphase and metaphase cytogenetics in detecting chromosome 7 defects in hematological neoplasias
Authors: Lian Zhao, June van Oort, Ann Cork, Jan C. Liang
Journal: American Journal of Hematology (1993)

Abstract Monosomy 7 (–7) is one of the most common chromosomal abnormalities found in the leukemic cells of patients with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). Because patients with –7 have a poor prognosis, their identification is important for treatment planning. Conventionally, –7 is detected by the G‐banding technique. This study examines the use of fluorescent in situ hybridization (FISH) methodology to detect –7 cells in interphase nuclei and metaphase chromosomes. Fifteen AML or MDS patients whose leukemic cells were found to have –7 by G‐banding at disease presentation were studied. In 13 of these patients, –7 could be detected in interphase by FISH using a chromosome 7‐specific centromeric DNA probe. The two patients whose leukemic cells were not detectable by interphase FISH had –7 and t(1q;7p), which were detectable by FISH in metaphase using a chromosome 7‐specific painting probe. Metaphase FISH was particularly useful in further defining chromosome 7 defects in cells that contained aberrant or marker chromosomes. For example, in 6 patients, chromosome 7 sequences were detectable in aberrant or marker chromosomes by metaphase FISH, but not by G‐banding. These results suggest that metaphase FISH is an important adjunct to conventional cytogenetic methods for defining chromosome 7 abnormalities in AML and MDS patients. Furthermore, interphase FISH is useful for follow‐up studies in patients who are found informative for the FISH study at presentation.
Effect of menopause on platelet activation markers determined by flow cytometry
Authors: Tariq M. Roshan, Jamalludin Normah, Asia Rehman, Lin Naing
Journal: American Journal of Hematology (2005)

Pre-menopausal women have a lower risk of cardiovascular disease compared to post-menopausal women. Cardiovascular disease is more age dependent in women than in men. The association of platelet activation and cardiovascular thrombotic events is well established. Standardized techniques were used to evaluate platelet activation markers by flow cytometry, using 3-color analysis (CD 61PerCP, CD 62P, and PAC-1) in 49 post-menopausal (mean ± SD age, 56.16 ± 33.51 years) and 42 pre-menopausal (age, 39.38 ± 7.07 years) women. Results of our study showed a significant increase in CD 62P in post-menopausal women as compared to the pre-menopausal group (2.66 ± 4.26% vs. 0.52 ± 2.71%, P < 0.001). Similarly, PAC-1 was significantly increased in post-menopausal women (21.54 ± 2.48% vs. 3.70 ± 2.31%, P < 0.001). Furthermore, there was a significant association of CD 62P with serum estradiol in both groups. PAC-1 was significantly associated with age in both groups. The results suggest the role of platelets in the increased incidence of thrombotic events and disease in post-menopausal women. Am. J. Hematol. 80:257–261, 2005. © 2005 Wiley-Liss, Inc.
Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34+ cells
Authors: Tessa C. C. Kerre, Greet De Smet, Magda De Smedt, Alfred Zippelius, Mikaël J. Pittet, Anton W. Langerak, José De Bosscher, Fritz Offner, Bart Vandekerckhove, Jean Plum
Journal: Blood (2002)
The prognostic value of myocardial viability recognized by low dose dipyridamole echocardiography in ischemic chronic left ventricular dysfunction
Authors: A. Borges, A. Djorkievic-Dikie, W. Mathias, R. Bigi, L. Cortigiani, J. Heyman, S. Polimeno, C. Baldi, R. Sican, E. Picano
Journal: Journal of the American College of Cardiology (1998)
Glucose-transporter–mediated positive inotropic effects in human myocardium of diabetic and nondiabetic patients
Authors: Dirk von Lewinski, Peter P. Rainer, Robert Gasser, Marie-Sophie Huber, Mounir Khafaga, Bastian Wilhelm, Tobias Haas, Heinrich Mächler, Ulrich Rössl, Burkert Pieske
Journal: Metabolism (2010)
Road-Deicing Salt and Cancer: the Need for Further Study
Authors: H. D. FOSTER
Journal: JNCI Journal of the National Cancer Institute (1993)

lead to severe 5-FU toxicity.This partial deficiency is in agreement with recent studies showing that 5-FU toxicity is related to altered drug elimination (9,70) and that lymphocyte DPD activity correlates to 5-FU clearance (3,4).This case and others raise the issue of the exact incidence of DPD deficiency in a large population of unselected cancer patients or in healthy individuals.These case reports highlight the need to define a lymphocyte activity threshold at which patients are at risk for 5-FU toxicity and to estimate the cost and/ or benefit ratio for a systematic pretreatment DPD activity determination in patients who are to be treated with 5-FU.
Abstract LB-167: Identification of ionizing radiation (IR)-responsive mRNA in p53-deficient human non-small cell lung cancer (NSCLC) grown in three-dimensional cell culture system
Authors: Jee Young Kwon, Jong Suk Kim, Young Rok Seo
Journal: Cancer Research (2010)

Abstract Non-small cell lung cancer (NSCLC) has been known as the most common human malignancy. The p53 tumor suppressor gene is mutated in approximately 50 % of NSCLC. For treatment of lung cancer, radiotherapy using -ray is general treatment. However, many patients suffer from recurred disease. Therefore, the definite mechanism of radiation based on in vivo mimic system is required for effective remedical value to NSCLC. Most of radiation biology studies were performed in conventional monolayer culture system which can not represent in vivo tumor environment. Hence, study applying in vivo mimic three-dimensional culture system is necessary to elucidate the molecular mechanism of solid tumor. Here, we analyzed gene expression profile induced by ionizing radiation (IR) in H1299 cells grown as spheroid in three-dimensional cell culture system. Our data showed that different gene expression profiles among monolayer culture system, three-dimensional small spheroid and three-dimensional large spheroid system. Particularly, genes related with microenvironment including adhesion junction and hypoxia had different expression level in three-dimensional spheroid system compare with monolayer culture system. This study suggested that in vivo mimic three-dimensional cell culture engineering approach might provide critical clues for understanding of cellular responses in p53 mutated or deleted lung cancer cells against IR. (* This work was supported by Nuclear Research Development Program of the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MEST). (Grand code: 2007-2001431, 2008-2001694, 2009-0078295) from Korea Science and Engineering Foundation) Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-167.
Reviews and Notes: Cardiology: The Evolution of Cardiac Surgery
Authors: Joel D. Howell
Journal: Annals of Internal Medicine (1993)

Literature of Medicine15 November 1993Reviews and Notes: Cardiology: The Evolution of Cardiac SurgeryJoel D. Howell, MDJoel D. Howell, MDUniversity of Michigan, Ann Arbor, MI 48109.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-10-199311150-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Evolution of Cardiac SurgeryHarris B. Shumacker, Jr. 476 pages. Bloomington, Indiana: Indiana University Press; 1992. $57.50.Is this the history of cardiac surgery or a history of cardiac surgery? The answers depend on what you think should constitute such a history.On the one hand, this book is a careful, detailed, and encyclopedic description of events. The author's implicit theoretical supposition is that to understand the history of cardiac surgery, the writings and speeches of cardiac surgeons should be used to create a list of discoveries and discoverers. To some, these assumptions will seem both obvious and unproblematic. For readers who ... Author, Article, and Disclosure InformationAffiliations: University of Michigan, Ann Arbor, MI 48109. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1993Volume 119, Issue 10Page: 1057KeywordsCardiac surgeryHand strengthHistory of medicineMedical sociologySurgeons Issue Published: 15 November 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
COMPLICATIONS FOLLOWING THE ADMINISTRATION OF HEDONAL
Authors: R. A. Veale
Journal: BMJ (1912)

SPINAL -ANAESTHESTA BY STOVAINh.T rnBICA 3N been necessary.Then by an error of judgement we gave him stovaine in the very case where it is not wise to give it, a patient weak from a co:iatinued septic fever and pyaemia, and death was entirely due to a sudden collapse, perhaps stovaine-induced, acting on a fatty septic heart.We have had no furtlher fatalities.The After-effects of Stovaine Anaesthesia.After a variable time, generally within an hoour or two at most, movements of the legs may be made and sensation returns.Pain in the legs is often complained of, and later headache and backache.The legs mnay sometimes give more trouble than anything else, but usually recover within two days.I have never seen any serious effects from stovaine, though fever, headache, giddiness, backache and retention of urine may persist for some days.Once the daingers at the time of the actual injection itgelf are over no further trouble is likely to occur.