Idiopathic Thrombocytopenic Purpura Occurring with Interstitial Pneumonitis
Authors: JOHN J. MAY
Journal: Annals of Internal Medicine (1979)

Brief Reports1 February 1979Idiopathic Thrombocytopenic Purpura Occurring with Interstitial PneumonitisJOHN J. MAY, M.D., MARVIN I. SCHWARZ, M.D., ROBERT B. DREISIN, M.D.JOHN J. MAY, M.D.Search for more papers by this author, MARVIN I. SCHWARZ, M.D.Search for more papers by this author, ROBERT B. DREISIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-199 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInterstitial pneumonitis occurs with connective tissue diseases and other disorders thought to be autoimmune in nature (Hashimoto's thyroiditis, chronic active hepatitis, pernicious anemia, autoimmune hemolytic anemia) (1, 2). The association of interstitial pneumonitis and idiopathic thrombocytopenic purpura has not previously been described. We present here a case documenting this association.An 81-year-old man was admitted after 9 months of progressive dyspnea and a 7-kg weight loss. He had a cough, moderate sputum production, and increased bruising. His respiration rate was 20 and he had bibasilar rales. His pulmonic second sound was increased. He had no hepatosplenomegaly or clubbing; large ecchymoses,...References1. TURNER-WARWICK M: Cryptogenic fibrosing alveolitis. Br J Hosp Med 7:697-704, 1972 Google Scholar2. SCADDING J: Fibrosing alveolitis with autoimmune haemolytic anaemia: two case reports. Thorax 32:134-139, 1977 CrossrefMedlineGoogle Scholar3. SCHWARZDREISINPRATTSTANFORD MRDR: Immunofluorescent patterns in the idiopathic interstitial pneumonias. J Lab Clin Med 91:929-938, 1978 MedlineGoogle Scholar4. DIXONROSSEEBBERT RWL: Quantitative determination of antibody in idiopathic thrombocytopenic purpura. Correlation of serum and platelet-bound antibody with clinical response. N Engl J Med 292:230-236, 1975 CrossrefMedlineGoogle Scholar5. THEOFILOPOULOSWILSONDIXON ACF: The Raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest 57:169-182, 1976 CrossrefMedlineGoogle Scholar6. DREISINSCHWARZTHEOFILOPOULOSSTANFORD RMAR: Circulating immune complexes in the idiopathic interstitial pneumonias. N Engl J Med 298:353-357, 1978 CrossrefMedlineGoogle Scholar7. MYLLYLÄVAHERIVESIKARIPENTTINEN GATK: Interaction between human blood platelets, viruses and antibodies. Post-Rubella thrombocytopenic purpura and platelet aggregation by Rubella antigen-antibody interaction. Clin Exp Immunol 4:323-332, 1969 MedlineGoogle Scholar8. KARPATKINSTRICKKARPATKINSISKIND SNMG: Cumulative experience in the detection of antiplatelet antibody in 234 patients with idiopathic thrombocytopenic purpura, systemic lupus erythematosus and other clinical disorders. Am J Med 52:776-785, 1972 CrossrefMedlineGoogle Scholar9. HENSONCOCHRANE PC: Immunological induction of increased vascular permeability. II. Two mechanisms of histamine release from rabbit platelets involving complement. J Exp Med 129:167-183, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Hospital Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAssociation of Immune Thrombocytopenia and Interstitial PneumoniaImmunohistological study of human lungs by immunoperoxidase technique.Rapidly fatal pulmonary fibrosis: the accelerated variant of interstitial pneumonitis. 1 February 1979Volume 90, Issue 2Page: 199-200KeywordsHepatosplenomegalyIdiopathic thrombocytopenic purpuraInterstitial lung diseasesLongitudinal studiesPernicious anemiaPlateletsRespirationSputumThyroidWeight loss Issue Published: 1 February 1979 Copyright©1979 American College of PhysiciansPDF DownloadLoading ...