The Use of Radioiron in the Study of Anemia
Authors: R. A. BOHANNON
Journal: Annals of Internal Medicine (1961)

Article1 December 1961The Use of Radioiron in the Study of AnemiaR. A. BOHANNON, M.D., J. L. HUTCHISON, M.D., F.R.C.P. (C), S. R. TOWNSEND, M.D., F.A.C.P.R. A. BOHANNON, M.D.Search for more papers by this author, J. L. HUTCHISON, M.D., F.R.C.P. (C)Search for more papers by this author, S. R. TOWNSEND, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-6-975 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe increasing use of radioisotopes in clinical medicine offers better means of understanding and quantitating physiological processes. Tracer techniques using isotopes of iron allow investigation of iron metabolism and erythropoietic function. Radioiron binds to transferrin, an alpha-1 globulin, which has the capacity of accepting two atoms of iron per molecule of protein. During its transport in the plasma, iron is removed from the plasma at an exponential rate into the bone marrow where it is soon utilized in hemoglobin synthesis. Normally only a small portion of iron leaves the plasma for storage. Subsequently, the tracer reappears in the peripheral circulation...References1. KAPLANZUELZERMORIQUAND EWWC: Sideroblasts: study of stainable nonhemoglobin iron in marrow normoblasts. Blood 9: 203, 1954. CrossrefMedlineGoogle Scholar2. LAURELL C: Studies on the transportation and metabolism of iron in the body with special reference to the iron binding component in human plasma. Acta Physiol. Scand. 14: Supp. 46: 1, 1947. Google Scholar3. DAVIESLEVINOBERHOLZER GBVG: The microestimation of serum iron and iron-binding capacity in normals and disease. J. Clin. Path. 5: 312, 1952. CrossrefMedlineGoogle Scholar4. LENTINOCOLLICARUBENFELD WCS: Radioactive iron techniques in clinical practice. J. A. M. A. 173: 481, 1960. CrossrefMedlineGoogle Scholar5. BOTHWELLHURTADODONOHUEFINCH THAVDMCA: Erythrokinetics. IV. The plasma iron turnover as a measure of erythropoiesis. Blood 12: 409, 1957. CrossrefMedlineGoogle Scholar6. HUFFHENNESSYAUSTINGARCIAROBERTSLAWRENCE RLTGREJFBMJH: Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders. J. Clin. Invest. 29: 1041, 1950. CrossrefMedlineGoogle Scholar7. LOEFFLER RK: The radioiron turnover test in clinical medicine. Rhode Island Med. J. 39: 371, 1956. MedlineGoogle Scholar8. BOTHWELLCALLENDERMALLETTWITTS THSBLJ: The study of erythropoiesis using tracer quantities of radioactive iron. Brit. J. Haemat. 2: 1, 1956. CrossrefMedlineGoogle Scholar9. TUDHOPEWILSON GRGM: Anaemia in hypothyroidism. Quart. J. Med. 29: 513, 1960. MedlineGoogle Scholar10. MOORE CV: The concept of relative bone marrow failure. Amer. J. Med. 23: 1, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal,Requests for reprints should be addressed to Richard A. Bohannon, M.D., Lymphoma Section, Sloan Kettering Institute, Memorial Center for Cancer and Allied Diseases, 444 East 68th Street, New York 21, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySmall-dose iron tolerance test and body iron content in normal subjectsThe syndrome of paroxysmal nocturnal hemoglobinuria 1 December 1961Volume 55, Issue 6Page: 975-988KeywordsAnemiaBlood plasmaBone marrowGlobulinsGratitudeHemoglobinHemolytic anemiaHospital medicinePatientsProteins Issue Published: 1 December 1961 PDF downloadLoading ...