Enalapril and Pregnancy-Induced Hypertension
Authors: MARSHALL D. LINDHEIMER
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 June 1988Enalapril and Pregnancy-Induced HypertensionMARSHALL D. LINDHEIMER, M.D., WILLIAM M. BARRON, M.D.MARSHALL D. LINDHEIMER, M.D.Search for more papers by this author, WILLIAM M. BARRON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-911_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Shubiger and colleagues (1) have confirmed that administering angiotensin-converting enzyme inhibitors to pregnant women can provoke renal failure in the newborn. However, why did they merely conclude that "angiotensin enzyme inhibitors such as enalapril may do limited [italics ours] harm to the fetus as long as the mother takes care of metabolism and excretion," rather than firmly stating that these drugs were contraindicated in gestation?Reports associating angiotensin-converting enzyme inhibition with fetal death in several animals species appeared as early as 1981 (2-4), prompting one of us to report (5) that this class of drugs should not...References1. SCHUBIGERFLURRYNUSSBERGER GGJ. Enalapril for pregnancy-induced hypertension: acute renal failure in a neonate. Ann Intern Med. 1988;108:215-16. LinkGoogle Scholar2. FERRIS T. Studies of uterine blood flow in the pregnant rabbit. Contrib Nephrol. 1981;25:44-9. CrossrefMedlineGoogle Scholar3. BROUGHTON-PIPKINSYMONDSTURNER FES. The effect of captopril (SQ 14,225) upon mother and fetus in the chronically cannulated ewe and in the pregnant rabbit. J Physiol (Lond). 1982;322:415-22. CrossrefGoogle Scholar4. FERRISWEIR TE. Effects of captopril on uterine blood flow and prostaglandin E synthesis in the pregnant rabbit. J Clin Invest. 1984;71:809-15. CrossrefGoogle Scholar5. LINDHEIMERKATZ MA. Hypertension in pregnancy (current concepts). N Engl J Med. 1985;313:675-80. CrossrefMedlineGoogle Scholar6. MALLIECOULONBILLERYFAUCOURTMORIN JGCAJ. In utero aminoglycoside induced nephrotoxicity in rat neonates. Kidney Int. 1988;33:36-44. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The University of Chicago Medical Center Chicago, IL 60637 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFetopathy associated with exposure to angiotensin converting enzyme inhibitors and angiotensin receptor antagonistsAngiotensin converting enzyme inhibitors in pregnancyFetotoxicity of angiotensin-converting enzyme inhibition in primate pregnancy: A prospective, placebo-controlled study in baboons (Papio hamadryas)Risks of angiotensin-converting enzyme inhibition during pregnancy: Experimental and clinical evidence, potential mechanisms, and recommendations for useAngiotensin-converting enzyme inhibitors, an embryopathic class of drugs with unique properties: Information for clinical teratology counselorsMaternal and uteroplacental hemodynamic effects of chronic captopril in the hypertensive, term-pregnant ratPregnancy After Liver Transplantation: Effects of Immunosuppressive Therapy and Abnormal Hepatic FunctionSuccessful pregnancy with scleroderma renal disease and pulmonary hypertension in a patient using angiotensin converting enzyme inhibitors.Enalapril, Pregnancy, and Package CircularsJanet E. Rush, MD 1 June 1988Volume 108, Issue 6Page: 911-911KeywordsDrug metabolismDrugsEnzyme inhibitorsEnzyme metabolismExcretionFetal deathFetusesHypertensionPregnancyRenal failure Issue Published: 1 June 1988 PDF DownloadLoading ...