tbuckley/cabot-search huggingface dataset:
HUMAN PLASMA ALPHA 2-MACROGLOBULIN
Authors: Peter C. Harpel
Journal: The Journal of Experimental Medicine (1970)

Activation of plasma kallikrein arginine esterase activity by kaolin resulted in peak activity at 1 min of incubation and a 50% reduction in activity at 5 min in normal plasma, and 30% reduction in the plasma of patients with hereditary angioneurotic edema who lacked the C1 inactivator. The peak esterolytic activity was inhibited by soybean trypsin inhibitor whereas the 5 min activity was resistant to this inhibitor. Acid treatment of normal and hereditary angioneurotic edema plasma destroyed the factor responsible for the fall in esterase activity at 5 min and the factor which rendered the esterase resistant to soybean trypsin inhibitor. Purified alpha(2)-macroglobulin inhibited approximately 50% of the TAMe esterase activity of purified plasma kallikrein without changing its activity toward basic amino acid esters. The interaction between the alpha(2)-macroglobulin and kallikrein resulted in alterations in the gel filtration chromatographic pattern of the TAMe esterase and biologic activity of kallikrein, indicating that kallikrein was bound to the alpha(2)-macroglobulin. The TAMe esterase activity of this complex, isolated by column chromatography, was resistant to C1 inactivator and SBTI. Studies of incubation mixtures of kallikrein, alpha(2)-macroglobulin and C1 inactivator suggested that these inhibitors compete for the enzyme, and that the alpha(2)-macroglobulin partially protects the esterase activity of kallikrein from C1 inactivator. The alpha(2)-macroglobulin isolated from kaolin-activated plasma possessed 240 times the esterolytic activity of the alpha(2)-macroglobulin purified from plasma treated with inhibitors of kallikrein and of its activation. The alpha(2)-macroglobulin blocked the uterine-containing activity and vascular permeability-inducing effects of plasma kallikrein. These studies suggest that the alpha(2)-macroglobulin is a major plasma inhibitor of kallikrein and provide a new example of an interrelationship between the coagulation, fibrinolytic, and kallikrein enzyme systems.
Contamination of ampicillin was probably due to reuse of disposable stoppers
Authors: H. Jeene
Journal: BMJ (1996)

7560 in 1995, these hospitals performed roughly half of all abortions and deliveries in Norway that year and served a similar proportion of the total population.There are no separate abortion clin- ics in Norway.Figure 1 shows that the number of abortions had increased by 5% in January and by 1 1% in February this year compared with the previous year.For the two months combined the largest increase in one institution was 22%.
Functional modification of CD11c+ liver dendritic cells during liver regeneration after partial hepatectomy in mice
Authors: Antonino Castellaneta, Alfredo Di Leo, Ruggiero Francavilla, Marcella Margiotta, Michele Barone, Annacinzia Amoruso, Laura Troiani, Angus W. Thomson, Antonio Francavilla
Journal: Hepatology (2006)

Local immunosuppression within the liver and sex steroid changes, in both blood and tissue during liver regeneration, are well-recognized events. Dendritic cells (DC) play pivotal roles in the induction and regulation of immune responses. Their numbers are expanded markedly in vivo by fms-like tyrosine kinase 3 ligand (Flt3L) administration, without modification of their maturation state. Recent evidence suggests that estrogen can modulate DC function and promote a Th2-type immune response. Few data are available concerning the role of DC in liver regeneration. After 75% partial hepatectomy (PH) in male C57BL/6 mice, CD11c+ liver (L)DC increased significantly within 6 hours and maintained an immature phenotype. Numbers returned to pre-hepatectomy levels by 24 hours. The expanded LDC population showed increased IL-10 and reduced IFN-gamma gene transcription. Using these DC compared with control LDC as T cell stimulators in 72-hour mixed leukocyte cultures, IL-10 production was enhanced and IFN-gamma production reduced. LDC isolated 6 hours after 75% PH exhibited enhanced estrogen receptor (ER) expression, concomitant with increased serum estrogen levels. By contrast, spleen (S)DC isolated before and after PH showed no significant changes in their function (maturation state, T cell stimulatory activity, cytokine production, and ER expression). Increased liver regeneration (more than 50%) was observed 48 hours after 40% PH in the Flt3L-pretreated compared with the PBS group. In conclusion, interstitial LDC may play a key role in local immune regulation during liver regeneration, possibly linking estrogen-mediated immune modulation and hepatocyte proliferation.
Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease
Authors: M Kidd
Journal: Gut (2001)

<h3>BACKGROUND</h3> South African <i>Helicobacter pylori</i> isolates are characterised by the universal presence of<i>cagA</i> but have differences in vacuolating cytotoxin gene (<i>vacA</i>) alleles which correlate with clinically significant disease. However, the candidate virulence marker gene <i>iceA</i> has not been investigated. <h3>AIM</h3> To characterise the genetic organisation and heterogeneity of<i>iceA</i> genotypes in different South African clinical isolates. <h3>PATIENTS AND METHODS</h3> We studied <i>H pylori</i> strains isolated from 86 dyspeptic patients (30 with peptic ulcer disease (PUD), 19 with distal gastric adenocarcinoma (GC), and 37 with non-erosive gastritis) for the presence of<i>iceA1</i> or <i>iceA2</i>genes, and for differences in the genetic organisation of<i>iceA2</i> by polymerase chain reaction, Southern hybridisation analysis, and sequencing. <h3>RESULTS</h3> Genetic analysis of <i>iceA1</i> demonstrated significant homology (92–95%) with the USA type strain 26695 and probably functions as a transcriptional regulator, while a novel variant (<i>iceA2D′</i>) of<i>iceA2</i> and marked differences in predicted protein secondary structure of the <i>iceA2</i>protein were defined. <i>iceA1</i> was detected in 68% and <i>iceA2</i> in 80% of all clinical isolates. Although approximately 40% of patients had both strains, a higher prevalence (p&lt; 0.01) of GC patients were infected with<i>iceA1 </i>isolates which were invariably<i>vacA</i> s1/<i>iceA1</i>(p&lt; 0.005 <i>v</i> gastritis). Isolates from PUD patients were distinguished by the structurally altered<i>iceA2D </i>variant (53%; p&lt;0.03<i>v</i> gastritis) while the<i>iceA2C</i> variant distinguished isolates from patients with gastritis alone (67%; p&lt; 0.005<i>v</i> PUD). <h3>CONCLUSION</h3> In this study, an association between <i>iceA1</i> and GC was noted while differences in variants of<i>iceA2</i> differentiated between PUD and gastritis alone. Combination analyses of<i>iceA</i> genotypes and<i>vacA</i> alleles supported these associations.
Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer
Authors: Andrew Wilber, Phillip W. Hargrove, Yoon-Sang Kim, Janice M. Riberdy, Vijay G. Sankaran, Eleni Papanikolaou, Maria Georgomanoli, Nicholas P. Anagnou, Stuart H. Orkin, Arthur W. Nienhuis, Derek A. Persons
Journal: Blood (2010)
Systemic Lysostaphin in Man — Apparent Antimicrobial Activity in a Neutropenic Patient
Authors: F. R. Stark, Charles Thornsvard, E. P. Flannery, M. S. Artenstein
Journal: New England Journal of Medicine (1974)

LYSOSTAPHIN, a peptide enzyme extracted from a strain of Staphylococcus staphylolyticus, has been dramatically effective in experimental Staph. aureus infections in animals.1 Topical applications have been useful in eliminating the nasal staphylococcal carrier state in man.2 Systemic use of lysostaphin in man has not been encouraged because of potential immunogenicity.3 However, its use in single, continuous, brief courses for overwhelming or unresponsive staphylococcal infections has been proposed. A single trial of systemic lysostaphin was attempted in a young man with unresponsive leukemia who was suffering from staphylococcal pneumonia, multiple abscesses, and cellulitis. Death from daunomycin-induced heart failure shortly after . . .
THE TREATMENT OF PARALYTIC TALIPES VALGUS BY TENDON TRANSPLANTATION
Authors: B. Kilvington
Journal: BMJ (1907)

du sommeil (this circular was drawn up by Dr. Van Campenhout for distribution among the officials of the Congo Free State; he has based his recommendations on his own experience and on information received from the Liverpool School of Tropical Medicine; he strongly advises the use of this drug in all stages of .sleeningsickness).
Plasma lipids and lipoprotein cholesterol concentrations in people with different diets in Britain.
Authors: M Thorogood, R Carter, L Benfield, K McPherson, J I Mann
Journal: BMJ (1987)

Concentrations of total cholesterol and cholesterol in the various lipoprotein fractions were measured in vegans, vegetarians, fish eaters (who did not eat meat), and meat eaters. Total and low density lipoprotein cholesterol concentrations were higher in meat eaters than vegans, with vegetarians and fish eaters having intermediate and similar values. High density lipoprotein cholesterol concentration was highest in the fish eaters but did not differ among the other groups. There were striking trends with age in total and low density lipoprotein cholesterol concentrations, which differed between men and women: women showed a steady increase in concentration with age, whereas concentrations in men did not increase appreciably after the age of 40, which may partly explain sex differences in the prevalence of coronary heart disease. The differences in total cholesterol concentration suggest that the incidence of coronary heart disease may be 24% lower in lifelong British vegetarians and 57% lower in lifelong vegans than in meat eaters.
The standard of care. 1
Authors: A. R. Holder
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deceased Donor Characteristics and Kidney Transplantation
Authors: Colm C. Magee
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence for Early Impairment of Macular Function With Pattern ERG in Type I Diabetic Patients
Authors: Salvatore Caputo, Mauro A S Di Leo, Benedetto Falsini, Giovanni Ghirlanda, Vittorio Porciatti, Angelo Minella, Aldo V Greco
Journal: Diabetes Care (1990)

The electroretinogram (ERG) elicited by alternating gratings at constant mean luminance (pattern ERG) is a focal response reflecting the activity of the directly stimulated retinal area. In addition, pattern ERG is related, unlike the flash ERG, to ganglion cell activity. Therefore, this technique may be used to evaluate the integrity of inner retinal layers in the macular region. In this study, the steady-state pattern ERG, in response to alternating gratings (1.7 cycles/deg spatial frequency; 9 degrees field size) temporally modulated at 8 Hz, was recorded in 42 type I (insulin-dependent) diabetic patients with zero to four microaneurysms on fluorescein angiography and a duration of disease less than 11 yr. No patient had concomitant ocular or systemic complications. Mean pattern-ERG amplitude was significantly reduced in patients compared with age-matched control subjects (analysis of variance, F = 25.6, P less than 0.0001). Significant differences were observed between control and diabetic subjects without retinopathy (Scheffé F test, P less than 0.0001), between control and retinopathic subjects (Scheffé F test, P less than 0.0001), and between diabetic patients without retinopathy and those with early retinopathy (Scheffé F test, P less than 0.02). Pattern-ERG amplitude was inversely correlated with duration of diabetes (r = 0.22, P less than 0.05). Our results suggest a macular dysfunction in early diabetes resulting from metabolic and/or vascular injuries in the neurosensory retina.
The Long-Term Follow-Up Care of Laryngectomized Patients
Authors: George F. Reed
Journal: JAMA (1961)

The postoperative care of laryngectomized patients frequently becomes the responsibility of physicians not specifically trained in the management of this type of patient. The author here discusses the many problems peculiar to these patients —the psychological outlook of the patient, family and physician; the care of the tracheostoma; the management of excess cough, crusting, and mucus production; the problems of "colds" and loss of taste and smell; the management of subsequent anesthesia; the questions regarding artificial voice production; and the important factors to be observed to detect recurrence early. These problems are dealt with not only as regards "how to," but also "why" and "when to" do the things necessary to provide adequate, sympathetic, and intelligent care of these patients.
PROGNOSTIC UTILITY OF FIBROBLAST GROWTH FACTOR-23 AFTER AN ACUTE CORONARY SYNDROME
Authors: Jacob A. Udell, David Morrow, Eugene Braunwald, Christopher Cannon, Dylan Steen, Petr Jarolim, Mary Ann Lukas, Andrzej Budaj, Christian Hamm, Jing Zhou, KyungAh Im, Marc Sabatine, Michelle O’Donoghue
Journal: Journal of the American College of Cardiology (2015)
Treatment of Injuries to Athletes
Authors: Thomas B. Quigley
Journal: JAMA (1977)

In the 14 years since publication of the first edition, this book has deservedly become the standard vade mecum for those involved in the prevention, diagnosis, and immediate treatment of injuries sustained in sports. It is, for its time, what the first scholarly volume, Thorndike's Athletic Injuries , was some 40 years ago.  Precisely and clearly, it tells the reader how to define the problem, what to do, and how to do it. It is firmly and uncompromisingly surgical in philosophy: I believe that when one can demonstrate complete severance of any single ligament or any combination of ligaments in the knee, surgical repair is mandatory. Not too long ago, this now universally accepted point of view was vigorously criticized by conservatives, who made a virtue of their surgical temerity or ineptitude.  Excellent chapters on rehabilitation by Fred Allman, MD; on the hand, by Gael Frank, MD; on craniocerebral injuries, by
Endoscopic Neodymium: Yttrium-Aluminum-Garnet Laser Papillotomy at 1.32 Microns Wavelength with One-Act Biliary Stenting in Patients with Cancer of Vater's Papilla
Authors: S. Karanov
Journal: Endoscopy (1993)

See also: Management of Non-neoplastic Stenoses of the GI-tract - A Further Indication for Nd-Yag Laser ApplicationEndoscopy 1984; 16(04): 149-151DOI: 10.1055/s-2007-1018562
Endoscopy of the Nose and Nasopharynx
Authors: M. Jaumann, W. Steiner
Journal: Endoscopy (1978)

Endoscopy of the nose and nasopharynx using rigid endoscopes and the zoom-laryngoscope-epipharyngoscope after v. Stuckrad enhances the diagnostics in these regions considerably. These "inaccessible" regions, remote structures and niches can easily be visualized by angle-endoscopes with magnification. Not only diagnostic procedures are facilitated but also some therapeutical manipulations. Especially for the early detection of cancer as for follow-up control and photo-documentation the endoscopes are of particular importance.
Medicolegal Issues in the Care of Addicts
Authors: DALE C. CAMERON
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 July 1967Medicolegal Issues in the Care of AddictsDALE C. CAMERON, M.D., M.P.H.DALE C. CAMERON, M.D., M.P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-209 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis is an opportune time to present the medicolegal issues to be considered by a physician undertaking the treatment, or other disposition, of narcotic-dependent persons (addicts) (1). In the past few years, there has been a marked increase in the attention given in professional and lay publications and other channels of communication to problems of narcotic and other drug dependence (addiction). Increasing numbers of physicians are finding the treatment of narcotic-dependent persons "respectable," but many still hesitate to become involved, sometimes because of lack of familiarity with the medical factors but also, too often, because of misunderstanding about the associate...References1. EDDYHALBACHISBELLSEEVERS NBHHMH: Drug dependence: its significance and characteristics. Bull. WHO 32: 721, 1965. MedlineGoogle Scholar2. : Narcotics and medical practice: the use of narcotic drugs in medical practice and the medical management of narcotic addicts. JAMA 185: 976, 1963. (Revision in press.) CrossrefMedlineGoogle Scholar3. : Narcotics and medical practice: the use of morphine and morphine-like drugs in medical practice and the medical management of persons dependent on them. In press. Google Scholar4. Prescribing and Dispensing of Narcotics Under Harrison Narcotic Law. The U. S. Treasury Department, Bureau of Narcotics, Pamphlet No. 56. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Elizabeth's Hospital Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1967Volume 67, Issue 1Page: 209-210KeywordsAddictsDrug addictionDrug dependence Issue Published: 1 July 1967 PDF DownloadLoading ...
TV or Not TV Communicating Health Information to the Public
Authors: Bruce B. Dan
Journal: JAMA (1992)

The invasion of American culture by television may prove to be the defining aspect of our modern times. It is difficult to imagine what our lives would be like without television's presence. Television has not only reflected our history, but to a great extent television has influenced it. It has been estimated that in the 1920s, the average adult in the United States spent only 3 to 4 hours per day using the media (newspapers, magazines, books, radio, and film), but with the advent of television, the time spent on media increased by 40%.<sup>1</sup> See also pp 999 and 1004. On average, Americans have their television sets on for 6 hours and 56 minutes each day (A.C. Nielsen Media Research, New York, NY, 1990-1991), and watching television has become our single most time-consuming leisure activity.<sup>2</sup>In fact, for most Americans, television is the medium from which they receive
Raman spectroscopy in pharmaceutical product design
Authors: Amrit Paudel, Dhara Raijada, Jukka Rantanen
Journal: Advanced Drug Delivery Reviews (2015)

Almost 100 years after the discovery of the Raman scattering phenomenon, related analytical techniques have emerged as important tools in biomedical sciences. Raman spectroscopy and microscopy are frontier, non-invasive analytical techniques amenable for diverse biomedical areas, ranging from molecular-based drug discovery, design of innovative drug delivery systems and quality control of finished products. This review presents concise accounts of various conventional and emerging Raman instrumentations including associated hyphenated tools of pharmaceutical interest. Moreover, relevant application cases of Raman spectroscopy in early and late phase pharmaceutical development, process analysis and micro-structural analysis of drug delivery systems are introduced. Finally, potential areas of future advancement and application of Raman spectroscopic techniques are discussed.
Effects of dietary and pharmacologic alteration of serum lipids on platelet survival time.
Authors: P Steele, J Rainwater
Journal: Circulation (1978)

Platelet survival time (SURV) (autologous labelling with 51Chromium) was shortened (3 +/- 0.03 days; average t 1/2 +/- SEM; normal t 1/2 3.7 +/- 0.03 days) in 88 out of 128 (69%) men with coronary disease. In 35 out of 47 men with hyperprebetalipoproteinemia, SURV was shortened (3 +/- 0.09 days) (74%). Of 30 men with hyperbetalipoproteinemia, SURV was shortened (2.5 +/- 0.10 days) in 26 (87%). Of 51 men without hyperlipoproteinemia, SURV was normal (3.3 +/- 0.10 days) in 24 (47%). Dietary alteration of serum triglyceride was undertaken in 12 men with hyperprebetalipoproteinemia, and in eight a decrease of triglyceride of more than 75 mg% was achieved (324 +/- 21-219 +/- 18 mg%; P less than 0.001) with an increase of SURV (2.2 +/- 0.11-2.8 +/- 0.13 days; P less than 0.001). In four, serum triglyceride increased by more than 75 mg% (279 +/- 14-451 +/- 28 mg%) and SURV decreased (2.7 +/- 0.16-2.3 +/- 0.21 days). Cholestyramine (16 g g.d.) and diet decreased serum cholesterol (348 +/- 7.6-319 +/- 6.3 mg%; P less than 0.001) in 15 men with hyperbetalipoproteinemia and SURV increased (2.3 +/- 0.08-2.7 +/- 0.07 days; P less than 0.001). Results suggest that SURV is shortened in men with coronary disease, particularly in those with hyperlipoproteinemia, and that alteration of triglyceride and cholesterol are associated with alteration of SURV.
The Use of Mammography for Screening-Reply
Authors: Karla Kerlikowske
Journal: JAMA (1994)

<h3>In Reply.</h3> —Dr Kopans suggests that the conclusions of our article on the PPV of screening mammography are biased and more sweeping than the data justify, and that we have targeted women younger than 50 years. In fact, we did not make a recommendation for or against screening average-risk women younger than 50 years. We concluded that efforts to promote screening mammography should focus on women 50 years of age or older and on women 40 years of age or older with a family history, in whom the majority of breast cancers occur (78% in our study) and in whom screening mammography has the highest PPV. We also recommended that all asymptomatic women who request or are offered screening mammography should be told the likely outcomes of screening. In addition, our article provides data about the performance of screening mammography that clinicians may use to inform women of likely outcomes