tbuckley/cabot-search huggingface dataset:
Determinants of 2-year outcome after coronary angioplasty in patients with multivessel disease on the basis of comprehensive preprocedural evaluation. Implications for patient selection. The Multivessel Angioplasty Prognosis Study Group.
Authors: S G Ellis, M J Cowley, G DiSciascio, U Deligonul, E J Topol, T M Bulle, M G Vandormael
Journal: Circulation (1991)

BACKGROUND To assess the likelihood of intermediate-term event-free survival (freedom from death, coronary artery bypass surgery, and myocardial infarction) in patients with multivessel coronary disease undergoing coronary angioplasty, 350 consecutive patients from four clinical sites were carefully evaluated and followed for 22 +/- 10 months. METHODS AND RESULTS Eight clinical variables were evaluated at the clinical sites, and 23 angiographic variables describing the number, morphology, and topography of coronary stenoses were evaluated at a core angiographic laboratory. Most patients had Canadian Cardiovascular Society class III or IV angina (72%), two-vessel coronary disease (68%), and well-preserved left ventricular function (mean ejection fraction, 58 +/- 12%; range, 18-85%). Follow-up was complete in 99% of patients. At 2 years, event-free survival was 72%, overall survival was 96%, freedom from bypass surgery was 82%, and freedom from nonfatal myocardial infarction without surgery was 96%. Sequential Cox proportional hazards regression analyses allowing stepwise entry of variables prospectively coded as simple, as of intermediate complexity, or as complex found event-free survival to be independently predicted by low Canadian Cardiovascular Society angina class, no diabetes, no proximal left anterior descending stenoses, and the sum of stenosis simplified risk-territory scores of 15 or less. In the absence of class IV angina and these risk factors, 2-year event-free survival was 87% and overall survival was 100%. In the presence of two or more of these risk factors, event-free survival was less than 50%. CONCLUSIONS Recognition of risk factors for poor long-term outcome in this setting may improve clinical decision making and provide a framework on which to base meaningful subgroup analyses in randomized trials assessing the efficacy of coronary angioplasty.
Pseudonephrotic Syndrome Caused by Lysozymuria
Authors: C. C. Mok
Journal: Annals of Internal Medicine (1994)

Letters15 November 1994Pseudonephrotic Syndrome Caused by LysozymuriaC. C. Mok, S. C. F. Tam, and Y. L. KwongC. C. MokQueen Mary Hospital, Pokfulam, Hong Kong.Search for more papers by this author, S. C. F. TamQueen Mary Hospital, Pokfulam, Hong Kong.Search for more papers by this author, and Y. L. KwongQueen Mary Hospital, Pokfulam, Hong Kong.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-10-199411150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A causal link between the nephrotic syndrome and acute leukemia is extremely rare [1]. Most reviews have focused on either glomerular or tubular injury that has resulted in urinary protein leakage. Lysozymuria itself as the cause of a gross proteinuria has not been previously reported.A 57-year-old man presented with a 2-week history of fever and bilateral ankle edema. His leukocyte count was 65 × 109/L (70% monoblasts), and examination of a bone marrow biopsy specimen confirmed the diagnosis of acute monoblastic leukemia. His urine had tested strongly positive for protein with a routine bedside strip test ...References1. Dabbs DJ, Striker LM, Mignon F, Striker G. Glomerular lesions in lymphomas and leukemias. Am J Med. 1986; 80:63-70. Google Scholar2. Burstein DM, Korbet SM, Schwartz MM. Membranous glomerulonephritis and malignancy. Am J Kidney Dis. 1993; 22:5-10. Google Scholar3. Farrant JM, Taylor CG, Beer SF. Nephrotic syndrome in chronic lymphocytic leukaemia. Br J Haematol. 1988; 69:419. Google Scholar4. Litwack G. Photometric determination of lysozyme activity. Proc Soc Exp Biol Med. 1955; 89:401-3. Google Scholar5. Perazella MA, Eisen RN, Frederick WG, Brown E. Renal failure and severe hypokalemia associated with acute myelomonocytic leukemia. Am J Kidney Dis. 1993; 22:462-7. Google Scholar Author, Article, and Disclosure InformationAuthors: C. C. Mok; S. C. F. Tam; Y. L. KwongAffiliations: Queen Mary Hospital, Pokfulam, Hong Kong. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHematological Malignancies and the KidneyLysozyme-Induced NephropathyRandom Spot Urine Markers for Kidney and Their ApplicationsRandom Spot Urine Markers for Kidney and Their ApplicationsPathogenesis, diagnosis and management of paraneoplastic glomerulonephritisA Forgotten Cause of Kidney Injury in Chronic Myelomonocytic LeukemiaConcurrent FSGS and Hodgkin's lymphoma: case report and literature review on the link between nephrotic glomerulopathies and hematological malignanciesAcute complications 15 November 1994Volume 121, Issue 10Page: 818KeywordsExcretionImmune complexLymphomaLysozymeMicroscopyProteinsProteinuriaTemperatureUrineVeins ePublished: 15 August 2000 Issue Published: 15 November 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Applying the bicoded spatial model to nonhuman primates in an arboreal multilayer environment
Authors: Allison M. Howard, Dorothy M. Fragaszy
Journal: Behavioral and Brain Sciences (2013)

Abstract Applying the framework proposed by Jeffery et al. to nonhuman primates moving in multilayer arboreal and terrestrial environments, we see that these animals must generate a mosaic of many bicoded spaces in order to move efficiently and safely through their habitat. Terrestrial light detection and ranging (LiDAR) technology and three-dimensional modelling of canopy movement may permit testing of Jeffery et al.'s framework in natural environments.
Global aid agencies boost support to poorer nations to fight flu threat
Authors: J. Zarocostas
Journal: BMJ (2009)

International agencies, spearheaded by the World Health Organization, are scaling up their support to low and middle income nations, including Mexico, to help them respond to the possible threat of an A/H1N1 flu pandemic.

All the poorest countries “with the greatest needs,” are being targeted, said Mike Ryan, WHO’s director for global alert and response. He said that the agency has begun to dispatch 2.4 million doses of antiviral drugs to 72 countries, including Mexico, from stocks donated by the drug company Roche in 2005 and 2006.

He said the most …
CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung
Authors: Cyrille Mionnet, Vanessa Buatois, Akira Kanda, Valerie Milcent, Sebastien Fleury, David Lair, Marie Langelot, Yannick Lacoeuille, Edith Hessel, Robert Coffman, Antoine Magnan, David Dombrowicz, Nicolas Glaichenhaus, Valerie Julia
Journal: Nature Medicine (2010)
Prostaglandin E2 Exerts Homeostatic Regulation of Pulmonary Vascular Remodeling in Allergic Airway Inflammation
Authors: J.A. Boyce, S. Nallamshetty, W. Xing, T. Laidlaw, C. Feng, S. Uematsu, S. Akira, A. Lundequist
Journal: Journal of Allergy and Clinical Immunology (2010)
THE REACTION OF STANDARD BREEDS OF RABBITS TO EXPERIMENTAL SYPHILIS
Authors: Paul D. Rosahn
Journal: The Journal of Experimental Medicine (1933)

A comparative study was made of the character and severity of the infection produced by Tr. pallidum in groups of standard bred Havana, Dutch, English, Himalayan, and Rex rabbits. All known variables that might influence the course of the disease were common to the different breed groups. On the basis of certain clinical data selected as criteria for the determination of variations in the response to syphilitic infection, it was found that the Havana and Dutch animals were resistant while the English, Himalayan, and Rex rabbits were susceptible. From these results, it appears that breed, race, or family is a factor which significantly influences the response to infection with Tr. pallidum.
Etoposide (VP-16–213)
Authors: Peter J. O'Dwyer, Brian Leyland-Jones, M. Teresa Alonso, Silvia Marsoni, Robert E. Wittes
Journal: New England Journal of Medicine (1985)

IN the 12 years since its introduction into clinical trials in the United States, etoposide (VP-16–213; epipodophyllotoxin; 4′-demethyl-9-[4,6–0-ethylidene-D-glucopyranoside]) has been demonstrated to be active in the treatment of several neoplastic disorders. Both etoposide and its congener teniposide (VM-26) have been the subjects of a program of detailed clinical research by the National Cancer Institute. Although data on teniposide are as yet incomplete, etoposide has been demonstrated to have cytotoxic activity against several tumors, including testicular and small-cell lung cancers, lymphoma, leukemia, and Kaposi's sarcoma associated with the acquired immunodeficiency syndrome (AIDS). In several other diseases, as we will show, its . . .
Preimplantation Diagnosis of the Cystic Fibrosis ΔF508 Mutation: What of the Other Two Embryos?
Authors: Charles W. Callahan
Journal: JAMA (1995)

To the Editor.  —Dr Liu and colleagues 1 recently reported the remarkably successful application of microsurgical techniques of epididymal sperm aspiration and intracytoplasmic sperm injection of stimulated oocytes. Following in vitro fertilization, blastomere biopsy was accomplished by micromanipulation. Analysis of DNA by polymerase chain reaction demonstrated the genotype of the embryos from two cystic fibrosis carriers.  Five embryos were successfully fertilized. Two were homozygous for the ΔF508 genotype and three were carriers. These three carriers were transferred to the uterus and one successfully implanted. Subsequently, a phenotypically normal male infant was born. 1 The article emphasized the preimplantation diagnosis of cystic fibrosis as well as the father's diagnosis of congenital bilateral absence of the vas deferens. The study, we are told, was approved by the institutional ethics committee. It is impossible to describe the joy that comes from the blessing of parenthood. We who are parents rejoice with this new
Iatrogenic Risk of Screening for Youth Suicide
Authors: W. E. Schlenger
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Malpractice Commission Report: Controversy Unabated; the Findings
Authors: William J. Curran
Journal: New England Journal of Medicine (1973)

THE first comprehensive national investigation of the "crisis" in medical-practice litigation in the United States has now been completed and the Report has been officially published.1 In the news release on the Report, Health, Education, and Welfare Secretary Weinberger greeted it as an important work of research and study and asserted that the findings and recommendations will "serve as a beginning for further public discussion of the problem of malpractice...."2 That it undoubtedly will be. However, it may also be a center of severe, quite bitter controversy. It is difficult to satisfy anyone in this field, let alone to achieve . . .
A Unified System of Care: Blueprint for the Future
Authors: ALLAN BEIGEL, WILLIS H. BOWER, ALAN I. LEVENSON
Journal: American Journal of Psychiatry (1973)

The authors describe the means used in Pima County, Arizona, to unify and coordinate the policies and procedures of a state hospital system and a community mental health system in order to provide more effective delivery of mental health services at the community level. The cooperation of the state hospital also permitted the development of a deterrent to unnecessary state hospitalization and a reduction in the number of patients to a level at which more specific therapeutic programs could be developed to meet the needs of the patients who remained.
Commissioning advocate resigns after becoming disillusioned with what GPs are being asked to do
Authors: Z. Kmietowicz
Journal: BMJ (2012)

A senior GP leader has resigned from her role as a commissioning champion for the Royal College of General Practitioners, citing the damage that the government’s policy will inflict on primary care in England and the role of GPs as advocates for patients.

Helena McKeown, a member of the RCGP’s council and a GP in Salisbury, told Pulse magazine that she had become “too disillusioned” with commissioning to continue to promote the policy. She would focus instead on exposing “what GPs are being set up to do,” she said.

The royal college launched its Centre for Commissioning in December 2010 to help GPs and the new GP consortiums develop the skills, competences, and expertise needed for commissioning and improving the quality of services for patients.1 

McKeown, who also chairs the BMA’s committee on community care, told Pulse …
COLICINE K
Authors: Hiroshi Matsushita, Maurice S. Fox, Walther F. Goebel
Journal: The Journal of Experimental Medicine (1960)

The synthesis of colicine K by the colicinogenic bacillus E. coli K(235) has been studied in the chemostat. It has been found that colicine production is influenced by the pH of the medium, by the nature of the primary carbon source, and by the generation time of the microorganism.
Target SHOs and registrars for communication skills training
Authors: Erik T Walbeehm
Journal: BMJ (2005)

EDITOR—Kidd et al argue that undergraduates need to learn clinical and communication skills side by side.1 Every doctor needs communication skills, from pathologists to surgeons and physicians. In the Netherlands undergraduates spend considerable time on how to communicate with patients. But I think that this is targeting the wrong group, and time is taken away from essential preclinical and clinical studies. Students learn …
Meningitis in Typhoid Fever
Authors: H. Tomkins
Journal: BMJ (1881)

only in chronic cases that will not yield to ordinary treatment ; 4. To use it only with the consent of the patient's friends; the nature of the treatment, and the effect of the croton-oil on the skin, being first fully explained.If the last rule be not carried out, parents are apt to think that their children are being over-treated.MENINGITIS IN TYPHOID FEVER.
Multiple Risk Factor Intervention Trial-Reply
Authors: Oglesby Paul
Journal: JAMA (1976)

<h3>In Reply.—</h3> The communication from Dr Hertzman expresses regret that alcohol use is not a "factor for consideration in correlation with other variables of high risk for coronary heart disease" in the Multiple Risk Factor Intervention Trial. The design of the trial has emphasized the importance of intervention for high blood pressure, elevated blood cholesterol levels, and the cigarette habit because laboratory, clinical, and epidemiological investigations have clearly implicated these three as having critical significance. Intervention for these three factors in a randomized trial is, we believe, scientifically sound and operationally feasible. We recognize that there are other variables of interest that might have been incorporated into the basic design, such as exercise, alcohol use, carbohydrate intake, and salt habits. To have included these as primary targets would have complicated further an already complex trial. Moreover, we do not believe that these and other factors possibly subject to modification have
Use of twins to study environmental effects.
Authors: J C Christian
Journal: Environmental Health Perspectives (1981)

Extrapolation from pharmacogenetic studies would indicate that there is a great deal of genetic variability in the response of humans to noxious environmental agents. Co-twins provide the most closely matched genetic controls possible and, in addition, are matched perfectly for age and often have shared very similar environments since before birth. The efficiency of co-twin control studies can be further increased by the use of sequential analysis, so that for the studies of the effects of environmental agents on human populations, twins would give answers that would require many more unrelated subjects. Use of twins in epidemiology studies is now in its infancy, but investigators should carefully consider the use of this powerful experimental tool and begin to identify twins in population surveys.
Measurement of Na(+)-K+ pump current in isolated rabbit ventricular myocytes using the whole-cell voltage-clamp technique. Inhibition of the pump by oxidant stress.
Authors: M J Shattock, H Matsuura
Journal: Circulation Research (1993)

Free radical-induced oxidant stress has been implicated in ischemia and reperfusion-induced injury in the heart. A number of studies have reported that oxidant stress reduces the activity of isolated Na+,K(+)-ATPase enzyme. We have studied the effects of oxidant stress on the Na(+)-K+ pump current recorded in isolated rabbit ventricular myocytes using the whole-cell voltage-clamp technique. Singlet oxygen and superoxide were generated by the photoactivation of rose bengal (50 nM). The compositions of Tyrode's and pipette solutions were designed to block channel currents and electrogenic Na(+)-Ca2+ exchange. Cells were dialyzed with a pipette solution containing 30 mM sodium via wide-tipped (1-2-M omega) electrodes, and outward Na(+)-K+ pump current was recorded during a voltage-ramp protocol. The validity of using such a ramp protocol was confirmed by comparison with steady-state Na(+)-K+ pump current measurements made at the end of 200-msec square-clamp steps. Active currents were abolished by potassium-free Tyrode's solution or ouabain (100 microM), and Na(+)-K+ pump current was defined as the Ko-sensitive fraction of recorded currents. The activation of Na(+)-K+ pump current by intracellular sodium and extracellular potassium revealed a concentration of potassium necessary for half-maximal activation of 18.7 mM for Nai and 1.88 mM for Ko. Oxidant stress inhibited Na(+)-K+ pump current at all voltages, such that after a 10-minute exposure to photoactivated rose bengal, Na(+)-K+ pump current measured at 0 mV was reduced by approximately 50%. The voltage dependence of Na(+)-K+ pump current was, however, not profoundly affected by oxidant stress. Passive membrane currents recorded in the absence of all major electrogenic ion channels, exchangers, or pumps were unaffected by oxidant stress. This observation suggests that, over the time course during which Na(+)-K+ pump inhibition and calcium overload occur, oxidant stress does not cause nonspecific membrane damage and changes in the passive resistance of the lipid bilayer. The inhibition of Na(+)-K+ pump activity by oxidant stress may contribute to ischemia/reperfusion injury and reperfusion-induced cellular calcium overload.
Decision-tree approach to the immunophenotype-based prognosis of the B-cell chronic lymphocytic leukemia
Authors: Nikola Mašić, Alenka Gagro, Sabina Rabatić, Ante Sabioncello, Gorana Dašić, Branimir Jakšić, Branko Vitale
Journal: American Journal of Hematology (1998)

Use of a nonlinear prediction method, such as machine learning, is a valuable choice in predicting progression rate of disease when applied to the highly variable and correlated biological data such as those in patients with chronic lymphocytic leukemia (CLL). In this work, decision-tree approach to cell phenotype-based prognosis of CLL was adopted. The panel of 33 (32 different phenotypic features and serum concentration of sCD23) parameters was simultaneously presented to the C4.5 decision tree which extracted the most informative of them and subsequently performed classification of CLL patients against the modified Rai staging system. It has been shown that substantial correlation between the percentage of expression of the CD23 molecule on CD19+ B-cells, the level of sCD23, the percentage of CD45RA+, and the absolute number of CD4CD45RA+RO+ T-cells and the clinical stages, exists. The prediction vector, composed of their concatenated values, was able to correctly associate 83% of the cases in the low-risk group (Rai stage 0), 100% of the cases in the intermediate-risk group (Rai stage I and II), and 89% of the cases in the high-risk group (Rai stage III and IV) of CLL patients. Predictivity of this vector was 100%, 95%, and 89%, respectively. In conclusion, from the described analysis, it may be inferred that two processes play important roles in the progression rate of CLL: 1. deregulated function of the CD23 gene in B-cells accompanied by the appearance of its cleaved product sCD23 in the sera; and 2. functionally impaired and imbalanced CD4 T-cell subpopulations found in the peripheral blood of CLL patients. Am. J. Hematol. 59:143–148, 1998. © 1998 Wiley-Liss, Inc.
White Coat Hypertension
Authors: Tsung O. Cheng
Journal: JAMA (1988)

<h3>To the Editor.</h3> —I read with interest the recent article by Pickering et al<sup>1</sup>entitled "How Common is White Coat Hypertension?" in the Jan 8 issue of<i>JAMA</i>. As the authors pointed out, the most obvious explanation for this phenomenon is that the rise in blood pressure is due to anxiety on contact with the physician or other health care personnel who wear a white coat. However, there is an equally important, though less well recognized, explanation, ie, the unreliability of a single initial reading of blood pressure. As is well documented from epidemiologic surveys referred to by these authors in their article, when a subject's blood pressure is measured the first time it is usually high but falls when measurement is repeated the second and third time. This phenomenon occurs