tbuckley/cabot-search huggingface dataset:
Cumulative Trauma Disorders of the Upper Extremities
Authors: Tom Bohr
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The article by Rempel et al<sup>1</sup>is a welcome addition to the growing literature on the subject of workrelated arm problems. However, there are some questionable neurological concepts that have recently come under more scrutiny by others. The authors equate the term "cubital tunnel syndrome" with the more common and accurate diagnosis of "ulnar neuropathy at the elbow." There is some evidence that only a minority of lesions actually occur within the cubital tunnel, and the conflation of these two terms adds to current confusion on the subject.<sup>2,3</sup> Earlier reports of the so-called pronator syndrome have been called into question recently, and the criteria for this syndrome are ill-defined and controversial. For many physicians, it seems to constitute a convenient "wastebasket" for lower arm pain, analogous to the way "thoracic outlet syndrome" has been used for other vague arm pains.<sup>3,4</sup> Some popular but questionable
Autoantibodies to bullous pemphigoid and epidermolysis bullosa acquisita antigens in an infant
Authors: Y. KAWACHI, M. IKEGAMI, T. HASHIMOTO, K. MATSUMURA, T. TANAKA, F. OTSUKA
Journal: British Journal of Dermatology (1996)

Journal Article Autoantibodies to bullous pemphigoid and epidermolysis bullosa acquisita antigens in an infant Get access Y. KAWACHI, Y. KAWACHI Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305, Japan. Search for other works by this author on: Oxford Academic Google Scholar M. IKEGAMI, M. IKEGAMI Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305, Japan. Search for other works by this author on: Oxford Academic Google Scholar T. HASHIMOTO, T. HASHIMOTO Department of Dermatology, Keio University School of Medicine, Shinjuku, Tokyo 160, Japan. Search for other works by this author on: Oxford Academic Google Scholar K. MATSUMURA, K. MATSUMURA Department of Dermatology, Keio University School of Medicine, Shinjuku, Tokyo 160, Japan. Search for other works by this author on: Oxford Academic Google Scholar T. TANAKA, T. TANAKA Department of Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan. Search for other works by this author on: Oxford Academic Google Scholar F. OTSUKA F. OTSUKA Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305, Japan. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 3, 1 September 1996, Pages 443–447, https://doi.org/10.1046/j.1365-2133.1996.d01-1018.x Published: 01 September 1996 Article history Accepted: 04 January 1996 Published: 01 September 1996
Effects on labile metabolites of temporal delay in freezing biopsy samples of dog myocardium in liquid nitrogen
Authors: T. B. ALLISON, C. A. RAMEY, J. W. HOLSINGER
Journal: Cardiovascular Research (1978)

Sudden hypothermia utilising liquid nitrogen has been used for immediate inhibition of metabolic reactions and preservation of labile compounds in heart muscle. It has been suggested that this rapid transfer of tissue into liquid nitrogen, within 1 to 2 s, is essential for accurate assessment of internal milieu conditions. We tested this hypothesis in normal dogs by measuring phosphocreatin, ATP, glycogen, and lactate concentrations in transmural layers of a core biopsy taken from the posterolateral wall of the left ventricle frozen immediately in liquid nitrogen or held at room temperature for varying times up to 300 s before freezing the tissue. The earliest significant change occurred in phosphocreatine levels after 60 s; only phosphocreatine demonstrated any changes within the first 120 s. These studies indicate that a delay of up to 30 s may be tolerated before freezing tissue without any change occurring in these labile metabolites.
Psychosomatic Aspects of Gynecological Disorders: Seven Psychoanalytic Case Studies
Authors: Natalie Shainess
Journal: JAMA (1969)

This little book is essentially a research monograph. It is solid yet at the same time baffling and elusive. Conceptually worthwhile, it reports the ketosteroid and hydroxycorticosteroid changes over a considerable period of time in seven women undergoing psychoanalysis, attempting to correlate these changes with phases in the analyses. The researchers have a clear and valid methodological approach, and, unaware of the pitfalls and complexities, recognize that their research falls short of yielding the correlates they seek. Yet the title is misleading, for this work does not fulfill its promise of enlarging the reader's understanding of psychosomatic gynecological disorders, but focuses on seven case histories in which secondary amenorrhea, premenstrual tension, and frigidity were presenting symptoms of serious personality disorders. The rather general and incomplete case reports (in contrast to the excellent and detailed steroid studies) are presented strictly in the opaque language of classical psychoanalysis, often expressing only the
The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis
Authors: Domenico Alvaro, Veronica Drudi Metalli, Gianfranco Alpini, Paolo Onori, Antonio Franchitto, Barbara Barbaro, Shannon S. Glaser, Heather Francis, Alfredo Cantafora, Ida Blotta, Adolfo Francesco Attili, Eugenio Gaudio
Journal: Journal of Hepatology (2005)
Chemotherapy for Tuberculosis
Authors: Laurence S. Farer
Journal: JAMA (1977)

To the Editor.—  I wish to point out an omission from advice given by Lees in QUESTIONS AND ANSWERS (237:1151, 1977). In discussing the management of a patient with recurrent episodes of cough and blood-streaked sputum after a thoracoplasty for tuberculosis 30 years previously, Lees made no reference to whether or not the patient had ever received chemotherapy. Former tuberculosis patients, such as the one described, are at higher risk of relapse if they have never had chemotherapy. For this reason, in addition to the management outlined, preventive therapy with isoniazid in a dose of 300 mg daily for one year should be offered to such a patient. 1
P135 Lung function in post-transplant multiple myeloma patients
Authors: H. McConkey, M. Streetly, S. Sachchithanantham, M. Gillion, M. Kazmi, K. Raj, H. J. Milburn
Journal: Thorax (2010)

<h3>Introduction</h3> Chemotherapy followed by autologous stem cell transplant (SCT) is the standard of care for patients with multiple myeloma. However, both conditioning and transplantation increase patient susceptibility to pulmonary complications, a major cause of morbidity and mortality. Pulmonary function tests (PFTs) are routinely performed before and after SCT, providing a means to detect any early decline in pulmonary performance. We report a retrospective analysis of patients undergoing treatment for myeloma at a tertiary London hospital with pre-and post SCT PFTs to assess the impact of transplantation on pulmonary function. <h3>Methods</h3> Patients were assessed with serial PFTs pre and post SCT (initially 6 weeks and thereafter 3 monthly). Standardised PFTs were expressed as a percentage of the pre-transplant value (100%). Tests were carried out by the same personnel, to ensure standardisation and eliminate variability in patient performance. <h3>Results</h3> 34 patients with myeloma with median age at SCT of 50 years (range 36–69) were analysed. Conditioning therapy utilised high dose melphalan in 14 and TBI in 18. Median follow-up was 12 months (range 1.5–102) and a median of 4.5 PFTs was performed (range 2–21). FEV<sub>1</sub> was reduced by &gt;10% in 14/34 and five of these had &gt;20%. FVC decreased &gt;10% in 7/34 and &gt;20% in 6/34. TLCO was reduced by &gt;10% in 23/34 and &gt;20% in 12/34 patients. KCO decreased in 25/34 (&gt;10%) and 12/34 (&gt;20%) patients. The median time for maximum reduction was between 2.25 and 4 months for all tests. An improvement in PFT to &gt;90% baseline occurred in over 50% of patients who had repeat investigations and this occurred within 24 months of initial PFT reduction. No significant difference was observed between TBI and melphalan based conditioning approaches. <h3>Conclusion</h3> Reductions in FEV<sub>1</sub> or FVC were observed in a minority of patients whereas a majority had a reduction in TLCO/KCO—a significant proportion experiencing &gt;20% fall. This reduction occurred early post transplant and improved for many. These changes may reflect possible pulmonary toxicity associated with conditioning therapy, post transplant lung injury or a combination of both and illustrates the necessity for regular prospective monitoring of PFTs following SCT for myeloma.
PHARMACODYNAMIC EFFICACY OF PRASUGREL MAINTENANCE THERAPY AT IN-HOSPITAL AND ONE-MONTH TIME POINTS: COMPARISON BETWEEN ST-ELEVATION MYOCARDIAL INFARCTION AND NON-ST-ELEVATION ACUTE CORONARY SYNDROME
Authors: Young-Hoon Jeong, Jong-Hwa Ahn, Jin-Sin Koh, Yongwhi Park, Choong Hwan Kwak, Jin-Yong Hwang
Journal: Journal of the American College of Cardiology (2015)
Lack of effect from a single cigarette challenge on bronchial responsiveness in healthy non-smoking subjects.
Authors: S Suzuki, F Sano, J Suzuki, H Numata, T Okubo
Journal: Thorax (1988)

The effect of smoking a cigarette on bronchial responsiveness was studied in healthy non-smokers. Twenty two subjects performed a methacholine inhalation test before and after smoking a single cigarette. Ten of the subjects took part in a further study in which propranolol was inhaled before the smoking challenge to diminish the baseline beta adrenergic tone of the airway. After they had smoked a single filtered or non-filtered cigarette the indices of bronchial responsiveness (the cumulative dose of methacholine starting a decrease in the reciprocal of resistance, Grs (Dmin), and the cumulative dose causing a 35% drop in the Grs (PD35Grs)) did not change significantly. With the inhalation of propranolol mean (SD) log Dmin decreased from 1.37 (0.44) units to 0.74 (0.57) (p less than 0.01) and log PD35Grs from 1.93 (0.38) to 1.51 (0.38) (p less than 0.01). Smoking a single cigarette after the inhalation of propranolol did not, however, cause any further change in bronchial responsiveness. This study suggests that smoking a single filtered or non-filtered cigarette does not change bronchial responsiveness in non-smokers, and that changes in beta adrenergic tone of the airway do not modify the effect of smoking a single cigarette on bronchial responsiveness.
TCT-259 Prevention of Radio-Contrast Mediated Acute Renal Injury with Intravenous Sodium Bicarbonate - Results of the PRIMARY Trial
Authors: Fernando Boccalandro, Laura Harmon, Tallat Fahim, Samia Sheikh, Juan C. Cardenas, Janie Lopez, Sudhir Amaram, Manohar Angirekula
Journal: Journal of the American College of Cardiology (2014)
CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death
Authors: Sara Serra, Alberto L. Horenstein, Tiziana Vaisitti, Davide Brusa, Davide Rossi, Luca Laurenti, Giovanni D'Arena, Marta Coscia, Claudio Tripodo, Giorgio Inghirami, Simon C. Robson, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio
Journal: Blood (2011)
The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function
Authors: C Kox, M Zimmermann, M Stanulla, S Leible, M Schrappe, W-D Ludwig, R Koehler, G Tolle, O R Bandapalli, S Breit, M U Muckenthaler, A E Kulozik
Journal: Leukemia (2010)

Precursor T-cell acute lymphoblastic leukemia (T-ALL) remains an important challenge in pediatric oncology. Because of the particularly poor prognosis of relapses, it is vital to identify molecular risk factors allowing early and effective treatment stratification. Activating NOTCH1 mutations signify a favorable prognosis in patients treated on ALL-BFM protocols. We have now tested if NOTCH pathway activation at different steps has similar clinical effects and if multiple mutations in this pathway function synergistically. Analysis of a validation set of 151 T-ALL patients and of the total cohort of 301 patients confirms the low relapse rate generally and the overall favorable effect of activating NOTCH1 mutations. Subgroup analysis shows that the NOTCH1 effect in ALL-BFM is restricted to patients with rapid early treatment response. Inactivation of the ubiquitin ligase FBXW7 is associated with rapid early treatment response and synergizes with NOTCH1 receptor activation. However, the effect of FBXW7 inactivation is separable from NOTCH1 activation by not synergizing with NOTCH1 mutations in predicting favorable long-term outcome, which can probably be explained by the interaction of FBXW7 with other clients. Finally, the comparison with other European protocols suggests that the NOTCH effect is treatment dependent generally and may depend on the intensity of central nervous system-directed therapy specifically.
Destruction of Contrast Microbubbles by Ultrasound
Authors: Taniyel Ay, Xavier Havaux, Guy Van Camp, Barbara Campanelli, Giovanna Gisellu, Agnès Pasquet, Jean-François Denef, Jacques A. Melin, Jean-Louis J. Vanoverschelde
Journal: Circulation (2001)

Background Recent experimental data indicate that ultrasound-induced destruction of ultrasound contrast microbubbles can cause immediate rupture of the microvessels in which these microbubbles are located. Methods and Results To examine the functional and morphological significance of these findings in the heart, isolated rabbit hearts were perfused retrogradely with buffer containing ultrasound contrast agents and were insonated at increasing levels of acoustic energy with a broadband transducer emitting at 1.8 MHz and receiving at 3.6 MHz and operated in the triggered mode (1 Hz). At the end of each experiment, the hearts were fixed in glutaraldehyde and examined with light microscopy. Neither exposure to ultrasound alone or to contrast alone affected left ventricular developed pressure. By contrast, simultaneous exposure to contrast and ultrasound resulted in a reversible, transient mechanical index (MI)-dependent decrease in left ventricular developed pressure (to 83±5% of baseline at an MI of 1.6) and a transient MI-dependent increase in coronary perfusion pressure (to 120±6% of baseline at an MI of 1.6). Myocardial lactate release also showed significant increases with increasing MIs. Macroscopically, areas of intramural hemorrhage were identified over the beam elevation in hearts exposed to both contrast and high-MI ultrasound. Light microscopy revealed the presence of capillary ruptures, erythrocyte extravasation, and endothelial cell damage. The mean percentage of capillaries ruptured at an MI of 1.6 was 3.6±1.4%. Conclusions Simultaneous exposure of isolated rabbit hearts to ultrasound and contrast agents results in an MI-dependent, transient depression of left ventricular contractile function, a rise in coronary perfusion pressure, an increase in lactate production, and limited capillary ruptures.
The 19th Annual Prostate Cancer Foundation Scientific Retreat
Authors: Guneet Walia, Kenneth J. Pienta, Jonathan W. Simons, Howard R. Soule
Journal: Cancer Research (2013)

Prostate Cancer Foundation (PCF) convened its 19th Annual Scientific Retreat October 25-27, 2012, in Carlsbad, CA. Each year, this event brings together diverse researchers in a collaborative forum to present and discuss new and largely unpublished findings for prostate cancer diagnosis, prognosis, and treatment and defines the challenges to ending this disease as a threat to life and well-being. Several themes resonated at the multidisciplinary meeting, notably (i) the roles of field cancerization, tumor microenvironment, epithelial plasticity, signal transduction pathways in cancer progression, and disease resistance; (ii) intratumoral heterogeneity and consequences for precision medicine; (iii) resistance mechanisms to androgen axis inhibitors; and (iv) advances in molecular imaging and therapeutics for better detection and treatment.
Oesophageal moniliasis causing fistula formation and lung abscess.
Authors: S Sehhat, K Hazeghi, M Bajoghli, S Touri
Journal: Thorax (1976)

Oesophageal moniliasis is reviewed and the incidence of fistula formation discussed. A case of oesophageal moniliasis without any predisposing factors, with fistula formation and lung abscess, is presented.
Depressive symptoms and heart rate variability in postmenopausal women: an ancillary study to the women's health initiative
Authors: Chin K. Kim, Beth A. Bartholomew, David Sheffield, Michelle Marsh, Tammy Dicken, Jackie Woodard, David Curb, Albert Oberman, Judith Hsia, Julius Gardin, Nathan Wong, Bruce Barton, Robert McMahon, David S. Sheps
Journal: Journal of the American College of Cardiology (2002)
In vivo fluorescence kinetics and photodynamic therapy in condylomata acuminata
Authors: I.M. Stefanaki, S. Georgiou, G.C. Themelis, E.M. Vazgiouraki, A.D. Tosca
Journal: British Journal of Dermatology (2003)

Background Topical application of 5-aminolaevulinic acid (ALA) to condylomata acuminata leads to accumulation of protoporphyrin IX (PpIX); therefore ALA-induced photodynamic therapy (ALA-PDT) appears to be a potential treatment. Objectives To investigate in vivo the PpIX fluorescence time course after topical application of ALA in order to determine the optimal time for irradiation, and to assess the efficacy of subsequently performed ALA-PDT. Methods Fluorescence kinetics was studied in 12 male patients with condylomata acuminata. Confirmation of diagnosis was established with conventional histology and polymerase chain reaction. Lesions were treated with 20% ALA and irradiated at the optimal time with a dose of 70 J cm−2 or 100 J cm−2 light. An additional session with 100 J cm−2 was administered 1 week later to lesions that persisted. Results The in vivo study of fluorescence kinetics indicated that the optimal time for irradiation varied among patients from 6 to 11 h. The overall cure rate was 72·9%, 12 months after treatment. Conclusions Topical ALA-PDT is a potentially effective treatment for condylomata acuminata.
Cataract Extraction Rates and Insurance Status
Authors: Andrew A. Dahl
Journal: JAMA (1997)

To the Editor.  —The article by Dr Goldzweig and colleagues 1 concludes that the incidence of cataract surgery is susceptible to financial and organizational incentives. Although this hypothesis may indeed be accurate, given human nature, the study itself does not necessarily lead to this conclusion.  The authors compare traditional Medicare (fee-for-service [FFS]) and a health maintenance organization (HMO) with both staff-model and network-model organizations. For the ophthalmologist-specialist, there is a major difference in reimbursement between the staff model, in which the physician is reimbursed through salary, and the network or independent practice association (IPA) model, in which reimbursement is FFS, usually at a higher level than traditional Medicare. The similarity in rates of cataract extraction between the staff model and the IPA implies that any motivational factors may be organizational, at a level distant from the specialist, but certainly are not based on financial considerations on the part of the
Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons
Authors: Alice Meunier, Alban Latrémolière, Annie Mauborgne, Sylvie Bourgoin, Valérie Kayser, François Cesselin, Michel Hamon, Michel Pohl
Journal: Molecular Therapy (2005)

Trigeminal neuropathic pain represents a real challenge to therapy because commonly used drugs are devoid of real beneficial effect or patients frequently become intolerant or refractory to some of these compounds. In a rat model of trigeminal neuropathic pain, which shares numerous similarities with human trigeminal neuralgia and trigeminal neuropathic pain, we used a genomic herpes simplex virus-derived vector (HSVLatEnk) to examine the possible effect of a local overproduction of proenkephalin A (PA) targeted to the trigeminal primary sensory neurons. Unilateral peripheral inoculation of recombinant vectors on the vibrissal pad territory resulted in an about ninefold increase in proenkephalin A mRNA levels in trigeminal ganglion ipsilateral to the infected side. Transgene-derived met-enkephalin accumulated in numerous nerve cell bodies of trigeminal ganglion and was transported through the sensory nerve fibers located in the infraorbital nerve. Bilateral mechanical hyperresponsiveness, which developed 2 weeks after chronic constrictive injury of the left infraorbital nerve, was significantly attenuated in animals overproducing PA in the trigeminal ganglion ipsilateral to the lesioned infraorbital nerve. This antiallodynic effect was reversed by both the opioid receptor antagonist naloxone and the peripherally acting antagonist naloxone methiodide. Our data demonstrate that the local overproduction of PA-derived peptides in trigeminal ganglion sensory neurons evoked a potent antiallodynic effect through the stimulation of mainly peripherally located opioid receptors and suggest that targeted delivery of endogenous opioids may be of interest for the treatment of some severe forms of neuropathic pain.