tbuckley/cabot-search huggingface dataset:
The 'Silent' Legacy of AIDS
Authors: Stephen W. Nicholas
Journal: JAMA (1992)

Over the past decade, efforts to improve the organization and provision of health care for families affected by the human immunodeficiency virus (HIV) have focused primarily on infected individuals. However, from the start it has been clear that children who were or would be orphaned as a result of the epidemic would add unique complexities to the equation. See also p 3456. How many children have been or will be orphaned by the acquired immunodeficiency syndrome (AIDS) epidemic? In this issue of<i>JAMA</i>, Michaels and Levine<i>1</i>estimate that 18 500 children and adolescents have already been orphaned. By 1996, this number will increase to 45 600 and by the year 2000 to 82 000 orphans. Additionally, tens of thousands of young adults will become motherless. These estimates, which are similar to recent Centers for Disease Control and Prevention (CDC) estimates,<sup>2</sup>are based on a set of reasonable assumptions
Amphetamine-like Reactions to Phenylpropanolamine
Authors: Albert J. Dietz
Journal: JAMA (1981)

Phenylpropanolamine hydrochloride is an amphetamine-like substance that is found in 64 different over-the-counter preparations for colds and appetite suppression. It is also found in numerous prescription drugs. Recently, it has been reported to cause symptoms of sympathomimetic-like effects, such as severe hypertension, hypertensive crisis, and possible renal failure. Also, several cases of psychotic episodes while taking phenylpropanolamine have been reported. This is the report of seven patients who have experienced acute CNS effects. These effects range from stimulation of the medullary respiratory center to tremor, restlessness, increased motor activity, agitation, and hallucinations.
THE OPERATIVE TREATMENT OF CYSTOCELE AND PROCIDENTIA UTERI.
Authors: E. C. DUDLEY
Journal: JAMA (1903)

The evolution of the operative treatment of cystocele and rectocele with resultant procidentia includes the following essential factors : 1. Operations of superficial denudation and reefing of the anterior vaginal wall as practiced by Sims and Emmet. 2. Operations on the lateral vaginal walls with superficial denudation, as described by myself and others. 3. The recognition of the essential fact that no operation can succeed that does not include plastic work on the lateral and anterior vaginal fornices with the definite purpose of forcing the cervix uteri back to its normal location in the hollow of the sacrum. All these measures have been employed with varying success, the variation being dependent on the ability of the operator to force the cervix uteri back into the hollow of the sacrum and to make it stay there. This location for the cervix is the prime indication. With the cervix uteri in its normal posterior location, the corpus uteri must necessarily fall forward into its natural position of anteversion.
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions
Authors: Kulandayan K. Subramanian, Yonghui Jia, Daocheng Zhu, Benjamin T. Simms, Hakryul Jo, Hidenori Hattori, Jian You, Joseph P. Mizgerd, Hongbo R. Luo
Journal: Blood (2007)
Epithelial adhesion molecules can inhibit HIV-1–specific CD8+ T-cell functions
Authors: Hendrik Streeck, Douglas S. Kwon, Augustine Pyo, Michael Flanders, Mathieu F. Chevalier, Kenneth Law, Boris Jülg, Kasper Trocha, Jonathan S. Jolin, Melis N. Anahtar, Jeff Lian, Ildiko Toth, Zabrina Brumme, J. Judy Chang, Tyler Caron, Scott J. Rodig, Danny A. Milner, Alicja Piechoka-Trocha, Daniel E. Kaufmann, Bruce D. Walker, Marcus Altfeld
Journal: Blood (2011)
EVALUATION OF LATE GADOLINIUM ENHANCEMENT AND FUNCTIONAL PARAMETERS BY MRI AND EVENTS IN CHAGAS HEART DISEASE
Authors: Gustavo Jardim Volpe, Henrique T. Moreira, Henrique S. Trad, Katherine C. Wu, Maria Fernanda B. Santos, Marcel K. Santos, Benedito C. Maciel, Jose Antonio Marin Neto, David A. Bluemke, Joao A C Lima, Andre Schmidt
Journal: Journal of the American College of Cardiology (2013)
Abstract 5721: Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining
Authors: Takahiro Oike, Hideaki Ogiwara, Takashi Nakano, Jun Yokota, Takashi Kohno
Journal: Cancer Research (2012)

Abstract Purpose: Non-homologous end joining (NHEJ), a major pathway to repair DNA double-strand breaks (DSBs) generated by ionizing radiation (IR), requires chromatin remodeling at DSB sites through acetylation of histones by histone acetyltransferases (HATs). However, effects of compounds with HAT inhibitory activities on DNA damage response (DDR), including NHEJ and cell cycle checkpoint, as well as on the radiosensitivity of cancer cells remain largely unclear. Here, we investigated whether garcinol, an HAT inhibitor found in the rinds of Garcinia indica fruit (called mangosteens), has effects on DDR and whether it can be used for radiosensitization. Methods and Materials: The ability of garcinol to inhibit DSB repair, including NHEJ, was examined by two assays; the conventional neutral comet assay and a cell-based assay recently developed by us, in which the activity of NHEJ against DSBs on chromosomal DNA was evaluated. The effects on cell cycle checkpoint after IR were assessed by phosphorylation levels of checkpoint kinases CHK1 and CHK2, and histone H3. The radiosensitizing effect was assessed by clonogenic survival assay. The effects on apoptosis and senescence were examined by annexin V and Senescence-associated β-galactosidase (SA-β-Gal) staining, respectively. Results: Garcinol was shown to inhibit DSB repair, including NHEJ, without affecting cell cycle checkpoint. Garcinol radiosensitized A549 lung and HeLa cervical carcinoma cells with a dose enhancement ratio at 10% surviving fraction of 1.6 and 1.5, respectively. Cellular senescence induced by IR was enhanced by garcinol. Conclusion: These results suggest that garcinol is a radiosensitizer that inhibits NHEJ and facilitates senescence, without impairing activation of cell cycle checkpoint. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5721. doi:1538-7445.AM2012-5721
Strukturanalyse einer Ehekrise mit Hilfe des «Gemeinsamen Rorschach-Versuches»
Authors: J. Willi, L. Ammann
Journal: Psychotherapy and Psychosomatics (1971)

The method of the 'Joint Rorschach Test' and its application in the quantitative evaluation of the structure and dynamics of dyads and groups has been described in previous publications. In the present work we have turned our attention primarily to the analysis of the content of the protocol obtained from the joint test. On the basis of a detailed description of a marriage crisis, we have shown how the Joint Rorschach Test can lead to a deeper understanding of the extremely complicated and disturbed relation between the partners. In particular it becomes clear, how the personality of one partner changes in the interaction with the other, how certain aspects of the personality are expanded or limited in depth and structure, or suppressed.
Letter: Vitamin C and the common cold.
Authors: M Carson, M Corbett, H Cox, N Pollitt
Journal: BMJ (1974)

A concentration of 15 pig/ml was arbitrarily taken as a level read.lyobtainable in h blood wiLh bo.h antibiotics.Th-19 strains resistant to penicillin and tetracycline only were resis:ant to tetracycline in con- centrations above 20 Ag/lml.This resis ance pattern occurs quite frequently in strains of S. aph.aureus isolated both from hospital patients and from the general comnnunity.It would appear therefore that any micro- biological advantage which minocycline may exert over other tetracyclines is due to its sup rior activity against strains of Staph.aureus which are resistant to tetracycline.' -I am, etc.,
Effect of coronary occlusion site on ischaemic bed size and collateral blood flow in dogs
Authors: K. A REIMER, R. E IDEKER, R. B JENNINGS
Journal: Cardiovascular Research (1981)

Journal Article Effect of coronary occlusion site on ischaemic bed size and collateral blood flow in dogs Get access KEITH A REIMER, KEITH A REIMER * From the Departments of Pathology and Medicine, Duke University Medical Center, Durham, North Carolina *Address correspondence and reprint request to: Dr. Keith A. Reimer, Box 3712. Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710 USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar RAYMOND E IDEKER, RAYMOND E IDEKER From the Departments of Pathology and Medicine, Duke University Medical Center, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT B JENNINGS ROBERT B JENNINGS From the Departments of Pathology and Medicine, Duke University Medical Center, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 15, Issue 11, November 1981, Pages 668–674, https://doi.org/10.1093/cvr/15.11.668 Published: 01 November 1981
Lindsay’s Nails in Chronic Kidney Disease
Authors: Catherine S Yang, Leslie Robinson-Bostom
Journal: New England Journal of Medicine (2015)

A 59-year-old woman who had undergone kidney transplantation 16 years earlier presented with an incidental finding of nail changes that had been present for at least 3 years. She was undergoing treatment with prednisone, mycophenolate mofetil, and tacrolimus for immunosuppression.
Obesity, Hypertension, and Cardiovascular Disease-Reply
Authors: Ellen Bloom
Journal: JAMA (1987)

In Reply.—  Dr Messerli's comments in his Letter to the Editor appear to contradict his own previously published statements. Here is a representative sample of quotations from his articles on obesity and hypertension:  Hypertension and obesity are two disorders that have been closely related, each occurring in greater frequency with the other than in an otherwise normal population. Although a causal relationship has not been established between the two, their coincidence carries increased risk of cardiovascular morbidity and mortality. 1   The combination of obesity and hypertension burdens the heart with high preload and high afterload, thereby greatly enhancing the risk of congestive heart failure.... Obesity hypertension may be the result of an inappropriately raised cardiac output in the presence of a relatively restricted arterial capacity due to the low vascularity of adipose tissue. 2   Since both obesity and hypertension increase cardiac workload, although by different mechanisms, their presence in the
Gastrointestinal Motility: Tests and Problem-Oriented Approach
Authors: Edy E. Soffer
Journal: Annals of Internal Medicine (2001)

Medical Writings: Book Notes6 February 2001Gastrointestinal Motility: Tests and Problem-Oriented ApproachEdy E. Soffer, MDEdy E. Soffer, MDThe Cleveland Clinic Foundation, Cleveland, Ohio. (Soffer)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-3-200102060-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Rao SS, ed. 310 pages. New York: Kluwer Academic/Plenum; 1999. $135.00. ISBN 0306461293. Order phone 781-871-6600.Field of medicine: Gastroenterology.Format: Hardcover book.Audience: Gastroenterologists, trainees, and practitioners who treat patients with gastrointestinal motility disorders.Purpose: To provide a guide for diagnostic and therapeutic approaches to common gastrointestinal motility problems in adults and children.Content: The material for the book was derived in part from the proceedings of the annual University of Iowa Gastrointestinal Motility Symposia. Twenty-nine chapters are grouped into six sections. The first section covers various diagnostic techniques. The next four sections address motility disorders affecting different segments ... Author, Article, and Disclosure InformationAffiliations: The Cleveland Clinic Foundation, Cleveland, Ohio. (Soffer) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 February 2001Volume 134, Issue 3Page: 260KeywordsAbdominal painAlgorithmsChildrenDecision makingDiagnostic techniquesGastrointestinal motility disordersGastrointestinal tractOropharynxSoftware tools ePublished: 6 February 2001 Issue Published: 6 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 3061: Tumor suppressive and angiogenic role of <i>THSD1</i> in esophageal squamous cell carcinoma and nasopharyngeal carcinoma
Authors: Josephine Mun Yee Ko, Arthur KL Cheung, Maria Li Lung
Journal: Cancer Research (2010)

Abstract Background and aims: Loss of chromosome 13q regions is a frequent event in both esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). By microcell-mediated chromosome transfer, chromosome 13 was demonstrated to play a significant tumor suppressive role in both ESCC and NPC in our laboratory. THSD1 is a novel candidate tumor suppressor gene (TSG) previously identified by microarray differential gene expression profiling. It encodes a transmembrane molecule containing a thrombospondin type 1 repeat (TSR), which may be involved in cell adhesion and angiogenesis. Proteins possessing the TSR, such as thrombospondin-1 (Tsp1), ADAM metallopeptidase with thrombospondin type 1 motif, 1 (ADAMTS1) and ADAMTS8, regulate angiogenesis. We previously showed that the mechanisms for THSD1 silencing in ESCC involved loss of heterozygosity and promoter hypermethylation. Our preliminary data indicated transfection of wild type THSD1 into an ESCC cell line, SLMT-1, resulted in significant reduction of colony-forming ability, hence providing functional evidence for its growth suppressive activity. The current study aims to examine if THSD1 plays a significant tumor suppressive role in the nude mouse tumorigenicity assay and to elucidate the mechanism(s) involved in tumor suppression. Methods: Transfection by lipofection of both variants of THSD1 into the ESCC SLMT-1 and NPC HONE1-2 cell lines was used to study the effect of THSD1 in tumor suppression and anti-angiogenesis. Results: Quantitative RT-PCR detected down-regulation of THSD1 expression in 36.4% (16/44) primary ESCC and 54.5% (12/22) NPC tissues. Nude mouse tumorigenicity assays showed tumor suppression in THSD1 over-expressing clones in both ESCC and NPC. Flow cytometry analysis showed over-expression of THSD1 resulted in endoreplication. Tube formation assay with HUVEC is underway to examine the angiogenic role of THSD1. Conclusions: THSD1 is a promising candidate TSG in both ESCC and NPC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3061.
Residential fungal contamination and health: microbial cohabitants as covariates.
Authors: R E Dales, D Miller
Journal: Environmental Health Perspectives (1999)

An association between symptoms and residential mold growth has been consistently observed in several countries, but the contribution of dust mites and bacterial endotoxins to this relation has not been established. To address this issue, we studied a sample of 403 Canadian elementary school children during the winter months. Reported mold growth was compared to respiratory and nonspecific symptoms before and after adjusting for dust mite antigens and bacterial endotoxin. A 12-50% relative increase in symptom prevalence was associated with reported mold growth both before and after adjusting for subject characteristics, dust mite antigens, and endotoxins. In conclusion, the association between residential fungal contamination and symptoms is not confounded by dust mites or bacterial endotoxins or other known disease-causing agents.
Use of Fat-Modified Foods for Serum Cholesterol Reduction
Authors: Jerome G. Green, Helen B. Brown, Alla P. Meredith, Irvine H. Page
Journal: JAMA (1963)

Dietary modification designed to reduce blood cholesterol concentrations usually requires detailed instruction and a restricted intake of many foods. In this study commercially prepared, fat-modified foods were supplied to young adults for 10 months. The altered foods were low in saturated fat and, in some, the "hard" fats were replaced with poly-unsaturated oils. Individual diet instruction was not given. The average reduction in serum cholesterol was 14%. Thus, significant hypocholesterolemic effects were obtained with suitably modified, palatable foods. This type of diet modification required little diet instruction and may prove to be a practical method for clinical and research use.
A molecular defect in hepatic cholesterol biosynthesis in sitosterolemia with xanthomatosis.
Authors: L B Nguyen, S Shefer, G Salen, G C Ness, G S Tint, F G Zaki, I Rani
Journal: Journal of Clinical Investigation (1990)

We examined the relationship between cholesterol biosynthesis and total and high affinity LDL binding in liver specimens from two sitosterolemic and 12 healthy control subjects who died unexpectedly and whose livers became available when no suitable recipient for transplantation was identified. Accelerated atherosclerosis, unrestricted intestinal sterol absorption, increased plasma and tissue plant sterol concentrations, and low cholesterol synthesis characterize this disease. Mean total microsomal HMG-CoA reductase (rate-control controlling enzyme for cholesterol biosynthesis) activity was sevenfold higher (98.1 +/- 28.8 vs. 15.0 +/- 2.0 pmol/mg protein per min) and microsomal enzyme protein mass was eightfold larger (1.43 +/- 0.41 vs. 0.18 +/- 0.04 relative densitometric U/mg protein) in 11 controls than the average for two sitosterolemic liver specimens. HMG-CoA reductase mRNA probed with pRED 227 and pHRED 102 was decreased to barely detectable levels in the sitosterolemic livers. In addition, there was a 50% decrease in the rate [2-14C]mevalonic acid was converted to cholesterol by sitosterolemic liver slices compared with controls (112 vs. 224 +/- 32 pmol/g liver per h). In contrast, average total LDL binding was 60% greater (326 vs. 204 +/- 10 ng/mg), and high affinity (receptor-mediated) binding 165% more active (253 vs. 95.1 +/- 8.2 ng/mg) in two sitosterolemic liver membrane specimens than the mean for 12 controls. Liver morphology was intact although sitosterolemic hepatocytes and microsomes contained 24 and 14% less cholesterol, respectively, and 10-100 times more plant sterols and 5 alpha-stanols than control specimens. We postulate that inadequate cholesterol biosynthesis is an inherited abnormality in sitosterolemia and may be offset by augmented receptor-mediated LDL catabolism to supply cellular sterols that cannot be formed.
A Carcinoid Tumor of the Rectum Removed by Strip Biopsy
Authors: Y. Fujimura, M. Mizuno, M. Takeda, I. Sato, K. Hoshika, J. Uchida, T. Kihara, T. Mure, K. Sano, T. Moriya
Journal: Endoscopy (1993)

In a 29-year-old male complaining of constipation, total colonoscopy revealed a 5 mm yellowish submucosal tumor at a distance of 6 cm from the anal ring. The histologic diagnosis of specimens obtained by biopsy was rectal carcinoid tumor and transanal ultrasonography revealed the tumor localization within the submucosal layer in the rectum. A strip biopsy was performed. Histopathological examination confirmed the diagnosis and ascertained complete excision. Rectal carcinoid tumors should be removed completely and strip biopsy may be a suitable procedure for removal of rectal submucosal tumors less than 10 mm in diameter.
THE DUTY OF THE MEDICAL PROFESSION TO THE PUBLIC IN THE MATTER OF VENEREAL DISEASES, AND HOW TO DISCHARGE IT.
Authors: W. J. HERDMAN
Journal: JAMA (1906)

Ignorance is the condition which alone makes slavery and oppression possible. This applies to the tyranny of disease quite as much as to the unjust dominion of man over man. Nothing should stand in the way of emancipating mankind from the tyranny of disease and especially of those diseases that are most destructive and wide-reaching in their effects. Physicians alone know the truth as to the widespread ravages of venereal diseases and on them rests primarily the duty of disseminating that truth so effectually that the way of escape from their dire effects may be made plain; and adequate safeguards for the protection of the innocent may be created. <h3>WHERE AND HOW SHOULD THIS TRUTH BE MADE KNOWN?</h3> So self-evident are the three leading propositions that head this paper that they need no discussion. The consensus of medical opinion the world over declares that the time is at hand for
Introduction a l'Etude des Malformations
Authors: Charles W. Bodemer
Journal: JAMA (1965)

Few concise summaries of the cardinal concepts and salient data of teratology are available to the general reader. This volume, one of the series,<i>Monographies de physiologie causale</i>, succeeds, with brevity of style and careful organization, in such a panoramic presentation without an overwhelming array of minutiae. The main chapters reveal the scope of the book: "Les principales malformations," "Les methodes expérimentales en teratologie et leur resultats," "Les mecanismes réalisateurs des malformations," and "Etiologie des malformations spontanées." Each chapter summarizes a wealth of information and the consistent inclusion of comparative data provides insight into the impressive complexity of teratogenesis. The sections devoted to genetic factors in malformations, "chemoteratogenesis," and the pharmacological aspects of developmental abnormalities receive particular attention. The discussion of mechanisms of teratogenesis will particularly interest those concerned with the still mysterious process of normal embryonic development and, although it may be questioned whether their classification according to the
Improvement of Dementia-Reply
Authors: Peter V. Rabins
Journal: JAMA (1983)

<h3>In Reply.—</h3> We thank Dr Walsh for his comments and note that he has long been interested in the care of demented patients and their families. We would disagree, however, with his recommendations regarding the use of anticoagulants in demented patients. His study<sup>1</sup>showed that two thirds of a group of patients whose conditions were diagnosed as demented improved after two years of treatment with warfarin sodium. However, there was no control group, and judgments about treatment response were not blind. Since the term<i>dementia</i>refers to a number of illnesses, many of which have variable courses, a controlled study is necessary. Furthermore, the most common dementing illness, Alzheimer's disease, is not associated with vascular abnormalities.<sup>2</sup>Thus, a therapeutic effect in patients with Alzheimer's disease seems unlikely. We also believe that there are possible risks involved in anticoagulating patients with dementia because they are prone to fall. The
C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages
Authors: Guillaume Hoeffel, Jinmiao Chen, Yonit Lavin, Donovan Low, Francisca F. Almeida, Peter See, Anna E. Beaudin, Josephine Lum, Ivy Low, E. Camilla Forsberg, Michael Poidinger, Francesca Zolezzi, Anis Larbi, Lai Guan Ng, Jerry K.Y. Chan, Melanie Greter, Burkhard Becher, Igor M. Samokhvalov, Miriam Merad, Florent Ginhoux
Journal: Immunity (2015)