tbuckley/cabot-search huggingface dataset:
Subcutaneous plasmacytomas with tropism to sites of previous trauma in a multiple myeloma patient treated with an autologous bone marrow transplant
Authors: Michael D. Rosenblum, Christopher N. Bredeson, Chung‐Che Chang, J. Douglas Rizzo
Journal: American Journal of Hematology (2003)

We report the case of a 59-year-old woman with Durie-Salmon stage IIIB IgGkappa multiple myeloma (MM), who presented 83 days after autologous hematopoietic stem cell transplant (HSCT) with multiple subcutaneous plasmacytomas. These lesions were confined exclusively to sites where the patient had sustained local trauma. The patient had no pre-transplant history of extramedullary disease and no evidence of plasma cells in the peripheral blood at any time throughout the course of her disease. This case represents the first report of refractory MM presenting as multiple subcutaneous plasmacytomas with specific tropism to sites of previous trauma. Selection of tumor cell subclones with unique chemokine receptor expression profiles that may explain this clinical observation is discussed.
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis
Authors: Martin E. Fernandez-Zapico, Natalia C. Gonzalez-Paz, Ellen Weiss, Doris N. Savoy, Julian R. Molina, Rafael Fonseca, Thomas C. Smyrk, Suresh T. Chari, Raul Urrutia, Daniel D. Billadeau
Journal: Cancer Cell (2005)
Prevalence and Cardiovascular Disease Correlates of Low Cardiorespiratory Fitness in Adolescents and Adults
Authors: Mercedes R. Carnethon, Martha Gulati, Philip Greenland
Journal: JAMA (2005)

HERE IS STRONG AND CONSIStent evidence from observational studies that physical inactivity and poor cardiorespiratory fitness (ie, fitness) are associated with higher morbidity and mortality from all causes, including cardiovascular disease (CVD) and cancer. 1 United States population reports describe an increasingly less physically active society, with marked downturns in reported physical activity during adolescence and young adulthood. 1-3Physical activity has been described in the population and in relation to health outcomes; however, prior to the current National Health and Nutrition Examination Survey (NHANES), 4 data were not available to quantify objectively determined cardiorespiratory fitness in the US population.A recently published large international case-control study attributed 12.2% of myocardial infarction in the world's population to physical inactivity. 5The extent to which physical inactivity affects the risk of heart disease through its negative impact on cardiorespiratory fitness, which is associated with a high prevalence of other CVD risk factors, is not known at the population level.The objectives of this report are to describe the prevalence of low fitness in the US population of adolescents and adults younger than 50 years and to relate low fitness to CVD risk factors in this population.
NARRATION
Authors: Harry Bloch
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse
Authors: Richard B. Lock, Natalia Liem, Monica L. Farnsworth, Christopher G. Milross, Chengyuan Xue, Mayamin Tajbakhsh, Michelle Haber, Murray D. Norris, Glenn M. Marshall, Alison M. Rice
Journal: Blood (2002)
Arthus reaction and pneumonia.
Authors: G Blandford
Journal: BMJ (1970)

IBWOUof "simple concussion."Once frank signs of clot compression have appeared, time sub- sequently spent in the x-ray department looking for skull fractures is precious time needlessly squandered.In the specific instance of possible penetrating wounds of the cranium, these are notoriously "invisi- ble" even on first-class standard projections of the skull.Patients suspected of such in- juries are better referred without delay to a neurosurgeon.It is common, though not universal, practice to x-ray the cervical spine at some stage in patients with cranial trauma, especially those who are or have been un- conscious.Only too often the view obtained is a lateral projection that fails to show C6, C7, or Ti.Only too often such films are assumed to exclude injury and further views are not requested.Lastly, positioning of the patient to secure adequate skull x-rays may be prejudicial to a co-existing but unsuspected cervical spine injury, particularly in an unconscious or otherwise injured casualty.In such cases it is arguable that neck x-rays should take priority over head x-rays.We suggest that these criticisms of some of Mr. Fowler's original points support rather than undermine his basic argument that it is better to exercise good clinical judgement than to depend on radiographs.We are, etc.,
Temporary Impairment of Vitamin B12 Absorption
Authors: Hendrick B. Barner, Theodore I. Jones, Thomas B. Garlick
Journal: JAMA (1964)

WIDESPREAD use of gastric freezing rapidly followed its introduction for the treatment of peptic ulcer. Despite this current vogue therapeutic results have been variable and temporary, and several hazards are known to be associated with the technique, We have demonstrated another untoward side effect which was previously thought not to occur.<sup>1</sup> <h3>Method</h3> Twelve male and four female patients, 24 to 67 years of age, with nonobstructing peptic ulceration of the duodenum documented by an upper gastro-intestinal study received a single, 60-minute period of gastric freezing employing a gastric hypothermia machine, as described by Peter and co-workers.<sup>2</sup>Inflow temperatures of —15 to —19 C (5 to —2.2 F) and outflow temperatures of —11 to —14 C (12.2 to 6.8 F) were maintained with a constant flow rate of 500 cc per minute. The volume of the standard, latex rubber balloon was the maximal consistent with patient comfort and ranged
Molecular characterization of β-thalassemia mutations in Guadeloupe
Authors: M. Romana, L. Keclard, G. Guillemin, E. Lavocat, C. Saint-Martin, C. Berchel, G. Mérault
Journal: American Journal of Hematology (1996)

In order to perform genetic counselling and prenatal diagnosis of Hb-S-beta-thalassemia disease and beta-thalassemia, we have delineated the spectrum of beta-thalassemia alleles in the Guadeloupean population. A sample of 63 unrelated families was analyzed including 70 beta-thalassemia carriers, 52 Hb-S-beta-thalassemia, and 8 patients with different beta-thalassemic hemoglobinopathies. Among the eleven mutations identified, four of them [-29 (A --> G), IVS-I-5 (G --> A), IVS-II-1 (G --> A), and IVS-I-5 (G --> C)] account for 77.6% of the beta-thalassemia chromosomes present in the studied families. The seven other variants, CD 24 (T --> A), IVS-I-2 (T --> C), Poly A (T --> C), -88 (C --> T), IVS- 11-849 (A --> G), Hb E, and Hb Lepore are less frequent. As a result, Hb S-beta+-thalassemia type 1 (low Hb A values: 5-15%) together with Hb S-beta(omicron)-thalassemia phenotypes are as frequent as Hb S-beta+-thalassemia type 2 (high Hb A values: 20-30%) in the Guadeloupean population. Patients with Hb S-beta+-thalassemia type 2 have milder hematological manifestations of the disease compared to patients with Hb S-beta(omicron)-thalassemia and Hb S-beta+-thalassemia type 1. This first report on the type and nature of beta-thalassemia mutations in Guadeloupe shows that prenatal diagnosis of Hb S-beta-thalassemia and beta-thalassemia should be feasible by direct detection of point mutation in most cases.
<i>Drosophila</i> in Asthma Research
Authors: Thomas Roeder, Kerstin Isermann, Michael Kabesch
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Genetic research has revealed a number of asthma-susceptibility genes. In addition, with the development of genome-wide association studies, which has gained unprecedented momentum, the roles of many more candidate genes in asthma will be uncovered. In parallel with such genetic insight, a detailed understanding of the function of susceptibility genes in asthma is required, a task best suited for genetically tractable model organisms. The inherent limitations of models like the mouse necessitate finding complementary systems for study. Although the fruit fly Drosophila has not been used previously in asthma-related research, it might prove to be extremely helpful in relating genetic processes to biological function. We discuss the usefulness of the Drosophila model by analyzing potential homologs of known asthma-susceptibility genes in the fly. Except for those associated with adaptive immunity, we and others found unequivocal orthologs for all of them. Most asthma-related genes are indeed expressed in the airway epithelium. In addition, some are regulated upon airway infection of the Drosophila airway epithelium, pointing to an important role in airway immunity and development of asthma-like phenotypes in the fruit fly. Finally, high throughput functional analyses are needed to complete genome-wide comparison studies in complex diseases such as asthma. Because such studies are most readily performed in the fruit fly, it may be a particularly useful asthma model system.
Prediction of gangrenous and perforating appendicitis in children.
Authors: D P Drake, J G Knott
Journal: BMJ (1978)

orthopaedic patients receiving antibiotics.' 2 The doubling of incidence of pseudomembranous colitis in Birmingham between 1976 and 1977 was probably due to increased diag- nostic vigilance.'The word "invariable" has no place in nosographic data processing and accordingly your statement that "diarihoea is invariable" requires scrutiny.While it is true that the colon is predominantly involved, the ileum can also, to a varying degree, be the seat of the disease.When the colon is completely spared -as in a recent case confirmed by necropsydiarrhoea can be absent.Clinically this case was dominated by abdominal pain, fever, and leucocytosis.A somewhat similar case was also reported recently.4In such cases sigmoido- scopic and proctoscopic examinations-usually useful methods for establishing the diagnosis- cannot be relied upon.Bearing in mind the topography of the pathological changes, I believe that diagnostic alertness might be enhanced by reverting to the original terminology-namely, pseudomembranous enterocolitis.
A prognostic model for predicting survival in cirrhosis with ascites
Authors: Glòria Fernández-Esparrach, Alberto Sánchez-Fueyo, Pere Ginès, Juan Uriz, Llorenç Quintó, Pere-Joan Ventura, Andrés Cárdenas, Mónica Guevara, Pau Sort, Wladimiro Jiménez, Ramón Bataller, Vicente Arroyo, Juan Rodés
Journal: Journal of Hepatology (2001)
ACUTE CHANGES IN RENAL EXCRETION OF WATER AND SOLUTE IN PATIENTS WITH LAENNEC'S CIRRHOSIS, INDUCED BY THE ADMINISTRATION OF THE PRESSOR AMINE, METARAMINOL*
Authors: Daniel L. Gornel, Ruben G. Lancestremere, Solomon Papper, Leah M. Lowenstein
Journal: Journal of Clinical Investigation (1962)

Excerpt In 1958, one of the authors (S. P.) presented to the Annual Session of the College clinical and experimental observations in patients with Laennec's cirrhosis who were dying with azotemia. ...
A SIMPLE AND RAPID METHOD OF LOCALIZING BULLETS
Authors: F. Hernaman-Johnson
Journal: BMJ (1914)

A METHOD OF LOCALIZING BULLETS.[OCT.3r, 19i4 Domestic cattle-sheep and horses--are also attacked.But, according to some authorities, poultry are not only attacked but killed by these parasites.The larvae apparently can, only live a few days in the skin of the victim.As far as is known at present the larvae of Trombidium convey no protozoal disease, but there is a terrifying little creature, known as the Kedana mite, which in some dis- tricts of Japan causes a serious illness, with a niortality of som-e 70 per cent.Apparently it does not act as an inoculating agent itself, but the papule surrounded by the red area wlicll forms as a result of its bite changes to a pustule, and tlle lesion becomes the point of entrance of bacteria whiclh produce the so called "river " or ";flood " fever.If these mites be carefully removedI tlle patient suffers no lharm.Anotlher species of miiite, Pediculoides veidricosuts, lives in stalks of serials anid is very apt to attack labourers wlho are dealing with grain.Their bites cause severe irritation, local swellings, reddening of the epidermis, alnd fever.In this particular species the female before shle is fertilized -has all elongated form 0.2 mm. in lenath and 0.07 mm:l. in brcad ih; but when fertilized the ovaries increase to such
Bronchoalveolar lavage in Waldenstrom's macroglobulinaemia with pulmonary infiltrates.
Authors: R B Filuk, P W Warren
Journal: Thorax (1986)

In 1944 Waldenstrom first described a lymphoproliferative disorder comprising anaemia, lymphocytic infiltrates, and raised serum concentrations of high molecular weight globulins.'Waldenstrom's macroglobulinaemia usually occurs
The Vav binding site of the non–receptor tyrosine kinase Syk at Tyr 348 is critical for β2 integrin (CD11/CD18)–mediated neutrophil migration
Authors: Jurgen Schymeinsky, Anca Sindrilaru, David Frommhold, Markus Sperandio, Ronald Gerstl, Cornelia Then, Attila Mócsai, Karin Scharffetter-Kochanek, Barbara Walzog
Journal: Blood (2006)
HAS THE MILK LABORATORY COME TO STAY?
Authors: A. C. COTTON
Journal: JAMA (1897)

Probably at no time in the world's history has the subject of infant feeding received so much attention as at present. The results of bacteriologic research and experimentation have of late given direction to the observations of some of the brightest minds of the profession, and the recent revival of interest in pediatrics has been due to the suggestions of the<i>preventability</i>of the disorders of the digestive tract of infants and children. It is not strange, then, that our recent literature teems with contributions on the subject of infant feeding. Some of our would-be teachers are dogmatic and precise in the presentation of their methods, while others are satisfied with the assumption of a merely suggestive attitude toward the subject, while still others present the plea of empiricism and point to results which they do not attempt to explain except upon the ground of experience. But amid all these
Fraction of normal remaining life span: a new method for expressing survival in cancer
Authors: J. S Vaidya, I. Mittra
Journal: BMJ (1997)

Conventionally, the time between diagnosis and date of last follow up or death is used to plot survival curves for patients with cancer.This ignores the patient's expected life span had the patient been healthy at the time of diagnosis.In human terms the impact of a projected prognosis of 10 year survival on a woman diagnosed as having breast cancer, for example, may be different depending on whether she is aged 30 or 70.Furthermore, oncologists have no answer to the question: "What is my chance of cure?"For this reason, we believe that survival is better expressed as a fraction of normal remaining life span expected at the time of diagnosis.We propose a new method which takes account of age at diagnosis in calculating survival.
A Population-based Study of Incidence, Risk Factors, Clinical Spectrum, and Outcomes of Ischemic Colitis
Authors: Siddhant Yadav, Maneesh Dave, Jithinraj Edakkanambeth Varayil, W. Scott Harmsen, William J. Tremaine, Alan R. Zinsmeister, Seth R. Sweetser, L. Joseph Melton, William J. Sandborn, Edward V. Loftus
Journal: Clinical Gastroenterology and Hepatology (2014)
Abstract B48: Resensitization to CDDP or trail-mediated apoptosis in ovarian cancer cells by Obatoclax.
Authors: Melisa A. Martinez-Paniagua, Luis A. Romero-Gonzalez, Yu-Mei Anguiano-Hernandez, Carolina Gonzalez-Torres, Mario I. Vega
Journal: Cancer Research (2013)

Abstract Ovarian cancer is the fifth cause of death in women, annually 13,850 deaths are reported in United States. Chemo is the conventional therapy after surgery but the initial response is between 60 to 80%, however, some patients that initially respond well to the therapy suffer recurrent disease or become resistant to the treatment. As a consequence, the overall 5 year survival is only 30%. There is a necessity to identify novel therapies for ovarian cancer or to discover drugs witch re sensitize tumor cells to existence therapy. It has been suggested that the resistance of the tumor cells is because of the increased expression of antiapoptotic proteins especially from the Bcl2 family (Bcl-2, Bcl-XL, Mcl-1). Obatoclax is a small molecule that mimics the BH3 domain of the BH3 only family members, inhibiting the effect of antiapoptotic Bcl-2 members. The objective of this study was to assess the susceptibility of ovarian cancer cell lines to chemo or immune therapy mediated apoptosis by obatoclax and also to elucidate the mechanism. Some ovarian cancer cell lines were treated with different concentrations of Obatoclax, CDDP or TRAIL alone or in combinational treatment to assess the reduction of viability measured by the XTT kit (Roche). Basal and cell treated total protein expressions were assessed by western. Induction of apoptosis was measured by TUNEL. As a single agent, Obatoclax or CDDP inhibited the growth of ovarian cancer cell lines in a dose response manner, TRAIL was no having an evident response showing a plateau with the concentration used. The combinational treatment after selecting the IC50 and IC20 response showed an increased inhibition of the viability. The induction of apoptosis was mediated by a caspase dependent manner. Our data suggest that obatoclax in combination with CDDP or TRAIL can re sensitize resistance cell lines to apoptosis and also it can be an optional treatment of patients with ovarian cancer. Citation Format: Melisa A. Martinez-Paniagua, Luis A. Romero-Gonzalez, Yu-Mei Anguiano-Hernandez, Carolina Gonzalez-Torres, Mario I. Vega. Resensitization to CDDP or trail-mediated apoptosis in ovarian cancer cells by Obatoclax. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; Dec 2-5, 2012; Miami, FL. Philadelphia (PA): AACR; Cancer Res 2013;73(1 Suppl):Abstract nr B48.
The osteogenic differentiation of adult bone marrow and perinatal umbilical mesenchymal stem cells and matrix remodelling in three-dimensional collagen scaffolds
Authors: Rebekka K. Schneider, Andrea Puellen, Rafael Kramann, Kerstin Raupach, Jörg Bornemann, Ruth Knuechel, Alberto Pérez-Bouza, Sabine Neuss
Journal: Biomaterials (2009)
Intrarenal Blood Flow in Congestive Heart Failure
Authors: MARGARET M. KILCOYNE, DONALD H. SCHMIDT, PAUL J. CANNON
Journal: Circulation (1973)

Intrarenal blood flow distribution was measured by the 133 xenon washout technic in 10 patients with heart disease who were studied at time of left and right heart catheterization. Renal washout curves were analyzed by computer using a weighted least-squares nonlinear regression technic. In three patients with heart disease without edema the compartment I blood flow rates (outer cortex) were not significantly different from those found in nine normal kidney donors. In seven patients with hemodynamic evidence of heart failure and clinical edema the compartment I flow rates were significantly lower than those of the normal control group and of a group of sodium-depleted hypertensive patients. The rate constants of isotope removal from more central regions of the kidney (compartments II and III) were not depressed to a similar degree. Infusion of furosemide into the renal artery induced diuresis in eight studies which was accompained by preferential increases in compartment I flow rates in six. The data suggest that preferential vasoconstriction of renal cortical vessels may contribute to increased sodium retention by the kidneys and to edema formation in patients with congestive heart failure.
Cavernous Sinus Thrombosis
Authors: Ayaz Agayev, Sabri Yilmaz
Journal: New England Journal of Medicine (2008)

A 34-year-old woman with a 3-year history of systemic lupus erythematosus was admitted to the hospital with sore throat and headache that had lasted for 3 weeks. She had been receiving cyclophosphamide for lupus nephritis for the previous 2 years. On the eighth hospital day, she reported severe headache and bilateral pain and bruising of the eyes. A day later, proptosis developed, with severe chemosis and eyelid edema, and her pupils were bilaterally nonreactive to light on examination. A preliminary diagnosis of extensive intracranial venous thrombosis was confirmed on magnetic resonance imaging. Axial T2-weighted imaging at the level . . .
Meeting Report: Development of Environmental Health Indicators in Brazil and Other Countries in the Americas
Authors: Fernando F. Carneiro, Mara Lúcia C. Oliveira, Guilherme F. Netto, Luis A.C. Galvão, Jacira A. Cancio, Estela M. Bonini, Carlos F. Corvalan
Journal: Environmental Health Perspectives (2005)

This report summarizes the Brazilian experience on the design and implementation of environmental health, with contributions from Argentina, Canada, and Cuba, presented at the International Symposium on the Development of Indicators for Environmental Health Integrated Management, held in Recife, Pernambuco, Brazil, on 17-18 June 2004. The methodology for the development of environmental health indicators has been used as a reference in the implementation of environmental health surveillance in Brazil. This methodology has provided tools and processes to facilitate the understanding and to measure the determinants of risks to environmental health, to help decision makers control those risks. Key words: environmental health indicators, environmental health surveillance, integrated management.