tbuckley/cabot-search huggingface dataset:
Urinary eosinophil protein X in relation to disease activity in childhood asthma
Authors: E. Lugosi, G. Halmerbauer, T. Frischer, D. Y. Koller
Journal: Allergy (1997)

Lugosi E, Halmerbauer G, Frischer T, Koller DY. Urinary eosinophil protein X in relation to disease activity in childhood asthma. The clinical use of urinary eosinophil protein X ‘U‐EPX’ measurements in monitoring inflammation in childhood asthma was investigated. U‐EPX and pulmonary function were assessed in 80 children with bronchial asthma and 24 healthy, age‐matched controls. In addition, 14 patients with asthma were re‐examined after 1–2 months. U‐EPX levels were increased in children with asthma compared with controls ‘median 68.4 vs 35.3 μg/mmol creatinine; P &lt; 0·0001’. In addition, U‐EPX levels were higher in symptomatic than in asymptomatic patients ‘median 123.5 vs 48·9 μg/mmol creatinine; P &lt; 0·0001’ independent of treatment modalities ‘i.e., inhaled steroids or disodium cromoglycate’ or atopy ‘median 65.1 vs 86·0 μg/mmol creatinine’. Furthermore, U‐EPX levels were significantly correlated with pulmonary function. During the follow‐up period, changes in U‐EPX values were significantly related to changes in pulmonary function. In conclusion, our findings demonstrate that eosinophil activation can be measured in urine in childhood asthma. Concentrations of U‐EPX are related to disease activity and pulmonary function, as shown in both cross‐sectional and longitudinal analyses, but are independent of atopy and treatment modalities. Measurement of U‐EPX may be useful in assessing the inflammatory process and therefore in the management of childhood asthma.
Transparency and trust: Clear definition of ghost writing would be helpful
Authors: Nicholas Moore
Journal: BMJ (2004)

EDITOR—The requirement that all authors have the idea, do all the work, get the data, analyse the data, and write the paper may be perfectly applicable to fundamental research, perhaps, or small clinical trials. In large studies it is not applicable: we are doing a 40 000 patient study of nonsteroidal anti-inflammatory drugs and …
A mutant PTH/PTHrP type I receptor in enchondromatosis
Authors: Sevan Hopyan, Nalan Gokgoz, Raymond Poon, Robert C. Gensure, Chunying Yu, William G. Cole, Robert S. Bell, Harald Jüppner, Irene L. Andrulis, Jay S. Wunder, Benjamin A. Alman
Journal: Nature Genetics (2002)
Th1, Th2, and activated T-cell marker and clinical prognosis in peripheral T-cell lymphoma, unspecified: comparison with AILD, ALCL, lymphoblastic lymphoma, and ATLL
Authors: Takeshi Tsuchiya, Koichi Ohshima, Kennosuke Karube, Takahiro Yamaguchi, Hiroaki Suefuji, Makoto Hamasaki, Chika Kawasaki, Junji Suzumiya, Masao Tomonaga, Masahiro Kikuchi
Journal: Blood (2003)
Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR
Authors: Glaucia E. Callera, Alvaro Yogi, Ana M. Briones, Augusto C.I. Montezano, Ying He, Rita C.A. Tostes, Ernesto L. Schiffrin, Rhian M. Touyz
Journal: Cardiovascular Research (2011)

We demonstrated c-Src activation as a novel non-genomic signalling pathway for aldosterone in vascular smooth muscle cells (VSMCs). Here, we investigated molecular mechanisms and biological responses of this phenomenon, focusing on the role of lipid rafts/caveolae and platelet-derived growth factor receptor (PDGFR) in c-Src-regulated proinflammatory responses by aldosterone. Studies were performed in cultured VSMCs from Wistar-Kyoto (WKY) rats and caveolin-1 knockout (Cav 1−/−) and wild-type mice. Aldosterone stimulation increased c-Src phosphorylation and trafficking to lipid rafts/caveolae. Cholesterol depletion with methyl-β-cyclodextrin abrogated aldosterone-induced phosphorylation of c-Src and its target, Pyk2. Aldosterone effects were recovered by cholesterol reload. Aldosterone-induced c-Src and cortactin phosphorylation was reduced in caveolin-1-silenced and Cav 1−/− VSMCs. PDGFR is phosphorylated by aldosterone within cholesterol-rich fractions of VSMCs. AG1296, a PDGFR inhibitor, prevented c-Src phosphorylation and translocation to cholesterol-rich fractions. Aldosterone induced an increase in adhesion molecule protein content and promoted monocyte adhesion to VSMCs, responses that were inhibited an by cholesterol depletion, caveolin-1 deficiency, AG1296 and PP2, a c-Src inhibitor. Mineralocorticoid receptor (MR) content in flotillin-2-rich fractions and co-immunoprecipitation with c-Src and PDGFR increased upon aldosterone stimulation, indicating MR-lipid raft/signalling association. We demonstrate that aldosterone-mediated c-Src trafficking/activation and proinflammatory signalling involve lipid rafts/caveolae via PDGFR.
Evaluation of Cerebral Blood Flow in Patients With Idiopathic Orthostatic Hypotension Using Tc-99m HMPAO Brain SPECT During Postural Testing
Authors: IKUO ODANO, NAOYA TAKAHASHI, TAKESHI HIGUCHI, MASAKI OHKUBO, SAI HAMA, AKIKO TSUDA, HIRO OTAKI, EIKICHI NOGUCHI, MASAYOSHI HATANO
Journal: Clinical Nuclear Medicine (1995)

To determine whether regional cerebral blood flow (rCBF) would change on standing in patients with idiopathic orthostatic hypotension (IOH), Tc-99m HMPAO SPECT studies were performed during postural testing in five patients with IOH. After 10 minutes of quiet rest on a bed, the patients arose quickly and, at the same time, the radiotracer was injected intravenously. SPECT data were obtained with a ring-type SPECT scanner. Another dose of Tc-99m HMPAO was injected with the subjects in the supine position, and SPECT was performed again. Image subtraction was used to evaluate the change in rCBF caused by postural testing. In all patients, the authors observed a decrease of rCBF ni the frontal cortex and basal ganglia. This preliminary study suggests that changes in rCBF occur in patients with IOH on standing, and Tc-99m HMPAO SPECT performed during postural testing may have an important role in evaluating these changes.
Esophagitis Related to Cromolyn
Authors: Robert H. Israel
Journal: JAMA (1979)

To the Editor.—  Adverse reactions to cromolyn sodium are infrequent, as evidenced by the study of Settipane et al (241:811, 1979). Only 2% of their 375 asthmatic patients treated with cromolyn had adverse reactions. One of the adverse reactions was gastroenteritis. This is an unusual reaction to cromolyn not previously reported. 1,2 The following is a recent case of a patient with symptoms of esophagitis after cromolyn inhalation.  Report of a Case.—  A 53-year-old woman entered the hospital with an exacerbation of her asthma. She had a 39-year history of extrinsic asthma that necessitated numerous hospitalizations during the summer months. Her condition was recently treated with oral aminophylline. She showed the sudden onset of rhinorrhea, sneezing, and lacrimation, followed by increasing shortness of breath and wheezing. Initial spirometric measurement disclosed severe airway obstruction. Aminophylline therapy was continued with the addition of terbutaline sulfate, steroids, and supplemental oxygen. After several days
Full smoking ban is needed in Germany as study finds four out of five pubs flout regulations
Authors: A. Tuffs
Journal: BMJ (2011)

Pubic health officials have called for Germany to introduce a national ban on smoking in all enclosed public places after research showed that the country’s16 federal states have largely failed to ban smoking in pubs, bars, and restaurants leaving guests and staff exposed to dangerous levels of smoke.

Martina Poetschke-Langer, head of the World Health Organization Office in Heidelberg, said that smoking was still a serious threat to people in restaurants and pubs. Results from studies …
From the Health Resources and Services Administration
Authors: Robert G. Harmon
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Varicella-Zoster Virus Detection by Polymerase Chain Reaction Using Bronchoalveolar Lavage Specimens
Authors: CLAYTON T. COWL, UDAYA B. S. PRAKASH, P. SHAWN MITCHELL, MICHAEL R. MIGDEN
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

We report the use of polymerase chain reaction (PCR) techniques from a bronchoalveolar lavage (BAL) specimen for the successful early diagnosis in a case of atypical but severe varicella-zoster virus (VZV) pneumonitis. Atypical presentations of disseminated VZV frequently prolong the time required for accurate diagnosis, resulting in increased morbidity, or mortality. Although further investigation is necessary to determine the sensitivity and positive predictive value of this test, PCR analysis of bronchoscopic specimens may expedite the diagnosis of disseminated VZV.
NARRATION
Authors: W. Leslie G. Quinlivan
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anatomic and Electrocardiographic Position of the Heart
Authors: NOBLE O. FOWLER, JOHN R. BRAUNSTEIN
Journal: Circulation (1951)

Thirty-four patients were studied by electrocardiogram for electrical position of the heart, and by x-ray and angiocardiogram for anatomic position of the heart. A significant association between electrocardiographic and anatomic positions of the heart was found insofar as rotation about the anteroposterior and longitudinal axes is concerned. No association between electrocardiographic and anatomic positions was found with regard to rotation about the transverse axis.
Myocardial Oxygen Consumption, Left Ventricular Fibre Shortening and Wall Tension
Authors: R. R. Taylor, H. E. Cingolani, T. P. Graham, R. L. Clancy
Journal: Cardiovascular Research (1967)

Myocardial oxygen consumption (MVO2) was studied in a canine right heart bypass preparation. At constant heart rate and left ventricular peak developed tension (calculated from ventricular volume and pressure), doubling cardiac inflow increased MVO2 by 1·3 ml./100 g LV/min. This approximate 10% increase is attributed to increased contractile element shortening and work.
Accelerated Renovascular Hypertension Following Angioplasty
Authors: G N LARAR, S T TREVES
Journal: Clinical Nuclear Medicine (1993)

This is a report of serial Tc-99m DMSA renal imaging on a pediatric patient with renovascular hypertension that experienced a complication of angioplasty. The case dramatically illustrates the usefulness of this radiopharmaceutical in the evaluation of acutely worsening hypertension, and in monitoring improvement following arterial revascularization for significant branch stenosis.
FDG PET/CT Findings of Thymic Carcinoid and Bronchial Carcinoid in a Patient With Multiple Neuroendocrine Neoplasia Type1
Authors: Takashi Abe, Motohiro Sato, Toshiyuki Okumura, Yasukazu Shioyama, Moriyuki Kiyoshima, Yuji Asato, Hitoaki Saito, Tatsuo Iijima, Ryuta Amemiya, Hideo Nagai
Journal: Clinical Nuclear Medicine (2008)

Thymic carcinoid is a rare thymic neoplasm and frequently accompanies neuroendocrine neoplasia (MEN) type1. Other carcinoid tumors derived from the foregut, like bronchial, gastric, and duodenal carcinoid are also of high incidence in MEN type1 patients. Recent studies revealed thymic carcinoid as a FDG-avid tumor, and FDG-PET is useful in detecting thymic carcinoid, its metastases, and recurrence. On the other hand, FDG accumulation in bronchial carcinoid is variable. We report a case of thymic carcinoid and bronchial carcinoid in a patient who was diagnosed as having multiple neuroendocrine neoplasia type1 previously. FDG PET/CT showed abnormal accumulation in the thymic atypical carcinoid and its mediastinal lymph node metastases, whereas the FDG did not show uptake in the typical bronchial carcinoid. These findings indicate that FDG PET is useful in detecting thymic carcinoid and its metastases.
A double-blind study of topical 1α,25-dihydroxyvitamin D3 in psoriasis
Authors: P.C.M. KERKHOF, M. BOKHOVEN, M. ZULTAK, B.M. CZARNETZKI
Journal: British Journal of Dermatology (1989)

Several open studies with active forms of vitamin D3 have been reported to be effective in the treatment of psoriasis. We report a double-blind study of 1 alpha,25-dihydroxycholecalciferol in psoriasis using 0.5 microgram of active substance applied topically twice daily. In contrast to previous studies, the present investigation does not provide evidence of clinical efficacy for the drug at that dosage and with the vehicle that was used.
The variable contribution of functional and anatomic barriers in human ventricular tachycardia: An analysis with resetting from two sites
Authors: David J. Callans, Marco Zardini, Charles D. Gottlieb, Mark E. Josephson
Journal: Journal of the American College of Cardiology (1996)

This study sought to investigate the influence of stimulation site on the properties of the circuit in ventricular tachycardia. A fully excitable gap can be demonstrated in most human ventricular tachycardias. This requires the presence of an arc of block so that the entire circuit can recover from refractoriness within the period of the cycle length. Resetting characterizes the conduction properties of the tissue within the ventricular tachycardia circuit. Previous studies have not investigated the possibility of site-dependent differences in the resetting response. Resetting was performed from the right ventricular apex and outflow tract in 23 patients. Two characteristics of the resetting response were analyzed: 1) the total duration of the flat portion, and 2) the slope of the increasing portion. A flat portion of the resetting response was observed in 18 tachycardias; in 8 of the 18, there was a significant site-dependent difference (≥40 ms) in the duration of the flat portion. A significant site-dependent difference in the slope of the increasing portion of the resetting curve was seen in 6 of 22 tachycardias. In all, a stimulation site-dependent change in at least one characteristic of the resetting response was seen in 12 (52%) of the 23 tachycardias. A stimulation site-dependent change in the flat portion of the resetting response is compatible with an arc of block that is at least partially functional in nature. A change in the slope of the increasing portion is compatible with either partially functional circuit barriers or variation in properties of conduction and refractoriness at different locations within the circuit, or both. These observations suggest that a spectrum of circuit properties may exist in humans, with a variable contribution of anatomic and functional characteristics.
Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses
Authors: Yang Z. Huang, Sandra Won, Declan W. Ali, Qiang Wang, Michael Tanowitz, Quan S. Du, Kenneth A. Pelkey, Da J. Yang, Wen C. Xiong, Michael W. Salter, Lin Mei
Journal: Neuron (2000)
Atlas of Infertility Surgery
Authors: Alvin M. Siegler
Journal: JAMA (1976)

The authors have filled a gap in the management of infertile patients by writing a fine book on operations needed to correct structural abnormalities in some of these women. Kistner and Patton stress the need for proper infertility studies prior to surgery and include a section describing gynecologic endoscopy. However, I cannot agree that hysterosalpingography is indicated only if complete tubal obstruction is demonstrated at the endoscopic examination. The chapters on uterine surgery, involving cerclage, metroplasty, and myomectomy, and the one on tubal reconstruction, comprising almost one half of the book, are especially lucid and comprehensive. The methods of selecting the proper patient and the operative techniques are clearly defined. This book should make the gynecologist more concerned with reconstructive and conservative surgery for benign pelvic disease in young patients. The chapter devoted to specialized instruments, although short, is inappropriate for this otherwise excellent text. The illustrations are clear and
Social Class and Recovery from Myocardial Infarction
Authors: L. Julian Haywood
Journal: Annals of Internal Medicine (1998)

Letters15 April 1998Social Class and Recovery from Myocardial InfarctionL. Julian Haywood, MDL. Julian Haywood, MDLos Angeles County-University of Southern California Medical Center; Los Angeles, CA 90033Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-8-199804150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The study by Ickovics and colleagues [1] clearly documents the independent effect of social class on functional outcome after myocardial infarction in men, and it documents that the effect of functional class is already present at baseline. This finding is consistent with our finding that the increased mortality and morbidity for black persons in the Beta-blocker Heart Attack Trial were associated with the larger constellation of risk factors at baseline [2]. Moreover, in later studies, we found that socioeconomic status was a clear influence on the health care-seeking behavior associated with suspected heart attacks [3, 4]. The ...References1. Ickovics JR, Viscoli CM, Horwitz RI. Functional recovery after myocardial infarction in men: the independent effects of social class. Ann Intern Med. 1997; 127:518-25. Google Scholar2. Haywood LJ. Coronary heart disease mortality/morbidity and risk in blacks. I: Clinical manifestations and diagnostic criteria. The experience with the Beta-blocker Heart Attack Trial. Am Heart J. 1984; 108:787-93. Google Scholar3. Ell K, Haywood LJ, Sobel E, deGuzman M, Blumfield D, Ning JP. Acute chest pain in African Americans: factors in the delay in seeking emergency care. Am J Public Health. 1994; 84:965-70. Google Scholar4. Ell K, Haywood LJ, deGuzmann M, Sobel E, Norris S, Blumfield D, et al. Differential perceptions, behaviors and motivations among African Americans, Latinos and whites suspected of heart attacks in two hospital population. Journal of the Association for Academic Minority Physicians. 1995; 6:60-9. Google Scholar Author, Article, and Disclosure InformationAuthors: L. Julian Haywood, MDAffiliations: Los Angeles County-University of Southern California Medical Center; Los Angeles, CA 90033 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWomen’s experience of a myocardial infarction: 5 years later 15 April 1998Volume 128, Issue 8Page: 695-696KeywordsBehaviorLongitudinal studiesMedical risk factorsMorbidityMortalityMyocardial infarctionSocioeconomic status ePublished: 15 August 2000 Issue Published: 15 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Patient has coronary artery bypass surgery while awake
Authors: D. Josefson
Journal: BMJ (2000)

A 51 year old man has undergone a coronary artery bypass graft while awake, marking the first time in the United States that such surgery has been performed without general anaesthesia.

The operation took place at the Veterans Administration Hospital in Pittsburgh, Pennsylvania, and was led by Dr Marco Zenati, an assistant professor of surgery at the University of Pittsburgh Medical Center, with the help of anaesthesiologist Dr Juhan Paiste.

Dr Paiste …
Effects of cisapride, a new gastrointestinal prokinetic substance, on interdigestive and postprandial motor activity of the distal oesophagus in man.
Authors: A J Smout, J W Bogaard, A C Grade, O J ten Thije, L M Akkermans, P Wittebol
Journal: Gut (1985)

Cisapride is a newly developed substance that stimulates gastrointestinal motility, possibly enhancing acetylcholine release in the gut wall. The aim of our study was to investigate the effect of cisapride on oesophageal motor function in man. In a blind fashion and in random order six healthy volunteers received cisapride (0.5 mg/h intravenously, preceded by a three day oral loading at 10 mg tid) and matching placebo. Oesophageal contractions and lower oesophageal sphincter pressure were constantly recorded during a complete cycle of the interdigestive migrating motor complex and during two and half hours after a mixed test meal. Cisapride did not disturb the interdigestive migrating motor complex. In the fasting state the lower oesophageal sphincter pressure showed considerable interdigestive migrating motor complex phase-related variations, whereas amplitude and duration of the oesophageal contractions did not. In the dosis used cisapride was found to increase lower oesophageal sphincter pressure in the interdigestive and in the late postprandial state, but to have no effect in the early postprandial period. Amplitude and duration of oesophageal contractions were not affected by cisapride.