Astemizole in the Treatment of Granulocyte Colony-Stimulating Factor-Induced Bone Pain
Authors: Rajashree Gudi
Journal: Annals of Internal Medicine (1995)

Letters1 August 1995Astemizole in the Treatment of Granulocyte Colony-Stimulating Factor-Induced Bone PainRajashree Gudi, Muthuswamy Krishnamurthy, and Bruce R. PachterRajashree GudiNew York Methodist Hospital; Brooklyn, NY 11215., Muthuswamy KrishnamurthyNew York Methodist Hospital; Brooklyn, NY 11215., and Bruce R. PachterNew York Methodist Hospital; Brooklyn, NY 11215.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-3-199508010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Granulocyte colony-stimulating factor (G-CSF) is commonly used to stimulate the production of granulocytes. A major side effect of G-CSF is bone and generalized muscle pain, which can last for 10 or more days. The pain may be severe enough to require narcotic analgesics [1]. It has been suggested that G-CSF may potentiate the inflammatory reaction by causing distinct cellular signaling and by increasing the histamine release [2]. An increase in histamine levels has been shown to cause nociceptive c-fiber-mediated pain and neuropathic pain [3]. Bennett [4] suggested that high levels of histamine can increase edema formation within ...References1. Weaver CH, Buckner CD, Longin K, Appelbaum FR, Rowley S, Lilleby K, et al. Syngeneic transplantation with peripheral blood mononuclear cells collected after the administration of recombinant human granulocyte colony-stimulating factor. Blood. 1993; 82:1981-4. Google Scholar2. Konig B, Konig W. Effect of growth factors on Escherichia coli α-hemolysin-induced mediator release from human inflammatory cells. Involvement of the signal transduction pathway. Infect Immun. 1994; 62:2085-93. Google Scholar3. Baron R, Saguer M. Postherpetic neuralgia. Are c-nociceptors involved in signaling and maintenance of tactile allodynia? Brain. 1993; 116:1477-96. Google Scholar4. Bennett A. The role of biochemical mediators in peripheral nociception and bone pain. Cancer Surv. 1988; 7:55-67. Google Scholar5. Martoni A, Zamagni C, Gheka A, Pannuti F. Antihistamines in the treatment of taxol-induced paroxystic pain syndrome. J Natl Cancer Inst. 1993; 85:676. Google Scholar Author, Article, and Disclosure InformationAffiliations: New York Methodist Hospital; Brooklyn, NY 11215. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPredictive factors in patients eligible for pegfilgrastim prophylaxis focusing on RDI using ordered logistic regression analysisPegfilgrastim-Induced Bone Pain: A Review on Incidence, Risk Factors, and Evidence-Based ManagementWhen Hydromorphone Is Not Working, Try Loratadine: An Emergency Department Case of Loratadine as Abortive Therapy for Severe Pegfilgrastim-Induced Bone PainRandomized phase II study of loratadine for the prevention of bone pain caused by pegfilgrastimLentinan mitigates therarubicin-induced myelosuppression by activating bone marrow-derived macrophages in an MAPK/NF-κB-dependent mannerPegfilgrastim use and bone pain: a cohort study of community-based cancer patientsSevere pegfilgrastim-induced bone pain completely alleviated with loratadine: A case reportThe five "Ws" for bone pain due to the administration of granulocyte-colony stimulating factors (G-CSFs)Types of Pain: Finding a Drug Regimen That WorksGranulocyte Colony-Stimulating FactorsSymptom Management in Children with CancerBenefits of GM-CSF Versus Placebo or G-CSF in Reducing Chemotherapy-Induced Complications: A Systematic Review of the LiteratureMobilization of Allogeneic Peripheral Blood Progenitor CellsRegulation of extracellular volume and interstitial fluid pressure in rat bone marrowChanges in serum osteocalcin and bone-specific alkaline phosphatase are associated with bone pain in donors receiving granulocyte-colony-stimulating factor for peripheral blood stem and progenitor cell collectionGranulocyte colony-stimulating factor 1 August 1995Volume 123, Issue 3Page: 236-237KeywordsAntihistaminesBoneChemotherapyGranulocyte colony stimulating factorGranulocytesHistamineMyalgiaNeuropathic painPainPatients Issue Published: 1 August 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...