tbuckley/cabot-search huggingface dataset:
Bone marrow trephine biopsy findings in myeloma with small‐lymphoid cells and <i>CCND1</i> translocation
Authors: Saad Abdalla, Philippa C. May, Elisa Garimberti, Kikkeri N. Naresh
Journal: American Journal of Hematology (2011)

A woman in her fifties presented with three episodes of epistaxis, occasional headaches, and episodic tiredness. Examination was unremarkable apart from pallor. Her hemoglobin measured 8.4 g/dL and rest of the blood counts were normal. The erythrocyte sedimentation rate was >120 mm/hr. An IgG lambda paraprotein of 74 g/L was detected. The beta-2-microglobulin was 2.8 mg/L. On serum free light chain evaluation, the kappa light chain measured 1.3 mg/L, and the lambda light chain measured 403 mg/L with a kappa:lambda light chain ratio of 0.003. The plasma viscosity was elevated at 3.72 MPa. The bone marrow aspirate showed extensive infiltration with small lymphoid appearing plasma cells amounting to 66% of all nucleated cells in the marrow. These cells had round nuclei of uniform size and coarse chromatin. Cytoplasm was variable in amount, but mostly scanty. Overall, the cells had a lymphoid or lymphoplasmacytic appearance (a&b; Giemsa ×1000). The bone marrow trephine biopsy showed hypercellular marrow (90% cellularity) (c; H&E ×40). There were sheets of small to medium sized lymphoid-like atypical plasma cells amounting to >90% of the marrow cells (d; H&E ×600). There were few binucleate forms as well. The cells expressed CD138 (e; ×600), CD79a, CD20 (f; ×600), cyclin D1 (g; ×600), CD56 and epithelial membrane antigen. There was lambda light chain restriction. Interphase fluorescent in-situ hybridization analysis on the bone marrow aspirate smear using a probe specific for IGH/CCND1 revealed a fusion signal, consistent with an IGH/CCND1 [t(11;14)] rearrangement, in 57 of the 100 cells analyzed (h). CCND1 gene overexpression is seen in nearly 50% of myeloma. About half of cases with cyclin D1 overexpression are associated with t(11;14). A small cell morphology of the tumor cells along with a strong cyclin D1 expression in a high percentage of tumor cells is highly indicative of t(11;14). About one-fifth to a third of myelomas express CD20, and the expression is associated with a mature small cell morphology of the neoplastic cells and with the presence of t(11;14). Such cases can be mistaken for small B-cell lymphomas, especially lymphoplasmacytic lymphoma, particularly if CD138 and cyclin D1 immunostains have not been performed. It is important to remember that lymphoplasmacytic lymphomas are negative for cyclin D1 expression.CCND1 is a crucial cellcycle gene located on chromosome band 11q13, which is overexpressed via chromosomal translocation t(11;14)(q13;q32) (leading to transcriptional deregulation), amplification, and other alterations. Studies of the prognostic significance of t(11;14) or of cyclin D1 overexpression in myeloma have yielded conflicting results [1, 2].
Consultation for physical illnesses by patients diagnosed and treated for psychiatric disorders by a general practitioner: 20 year follow up study.
Authors: G. Wilkinson, N. Smeeton, D. Skuse, J. Fry
Journal: BMJ (1988)

Patterns of consultation for physical illness were analysed in a body of consultation data covering a continuous 20 year period from a single general practitioner in south London. Three groups of adult patients were identified: patients with a psychiatric disorder and a new prescription for a psychotropic drug; patients with a psychiatric disorder but no new prescription for a psychotropic drug; and a control group without psychiatric disorder. The percentages of patients having one or more consultation for physical illnesses were stable over the years studied, being roughly 90%, 85%, and 60% respectively. For groups identified in 1972 their patterns of consultation for physical illness were examined in 1957, 1962, and annually from 1967 to 1976. In every year studied except 1957 the group with a psychiatric disorder and a new prescription for a psychotropic drug exceeded both other groups in the percentage of patients having one or more consultations for physical illnesses. Both groups with psychiatric disorders had an excess of consultations over the control group; this excess halved in about four years for the group with a new prescription and in about one year for the group without a new prescription. Mental health care by general practitioners for patients with psychiatric disorders does not seem to have an offset effect on general health care of these patients.
Do ACE Inhibitors Affect Diabetic Morbidity and Mortality?
Authors: George L. Bakris
Journal: Annals of Internal Medicine (1993)

Letters15 October 1993Do ACE Inhibitors Affect Diabetic Morbidity and Mortality?George L. Bakris, MDGeorge L. Bakris, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-8-199310150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I appreciate Dr. Brungardt's concern; however, nowhere did I refer to a reduction in overall mortality rate by these agents, given the absence of relevant data. My intent was to emphasize that ACE inhibitors have effects on the kidney that are independent of blood pressure reduction. The concept espoused was that these agents reduce renal mortality, not overall mortality.A recent analysis of many large, randomized studies that have evaluated the effects of the ACE inhibitors on cardiac events (including cardiac death rates) showed a significantly better outcome with ACE inhibitors compared with placebo [1]. These studies, however, ...REFERENCE1. Yusuf S, Pepine CJ, Garces C, Pouleur H, Salem D, Kostis J, et al. Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions. Lancet. 1992; 340:1173. Google Scholar Author, Article, and Disclosure InformationAuthors: George L. Bakris, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1993Volume 119, Issue 8Page: 860-861KeywordsACE inhibitorsBlood pressureDeath ratesKidneysMedical dialysisMedicareMorbidityMortalityRenal diseases ePublished: 15 August 2000 Issue Published: 15 October 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The uses of self-deception
Authors: Howard Rachlin, Marvin Frankel
Journal: Behavioral and Brain Sciences (1997)

The essence of a mental event such as self-deception lies in its function – its place in the life of an animal. But the function of self-deception corresponds to that of interpersonal deception. Therefore self-deception, contrary to Mele's thesis, is essentially isomorphic with interpersonal deception.
The Challenge of the Health Worker Migration Crisis to Health Reform in the United States
Authors: Michael O. Harhay, Nadya Meliza Munera Mesa
Journal: The American Journal of Bioethics (2009)

Click to increase image sizeClick to decrease image size Acknowledgment The authors wish to acknowledge that they are students at their affiliated institutions. Harhay in public health at the University of Pennsylvania in Philadelphia, PA, USA, and Mesa in medicine at the Facultad de Medicina, Fundacion Universitaria San Martin located in Medellin, Colombia.
Monocular Vision and Skiing
Authors: David P. Jahsman
Journal: JAMA (1966)

To the Editor:—  In regard to skiing and eye injuries ( 194 :477, 1965), the answer given regarding eye injuries in skiing by I. E. Hendryson, MD, was that eye injuries are not particularly common. He recommended that the patient in question be advised not to ski because of possible lack of depth perception associated with monocular vision.  I am expert neither in eye diseases nor in skiing, but have had monocular vision for 30 years and do ski.  The person who has only one eye soon learns depth perception through the use of parallax. This enables participation in a number of activities such as tennis, table tennis, contact sports, basketball, flying, etc. Skiing on slopes where there are trees and other objects which permit the individual to make use of parallax is reasonably safe. Under conditions of flat lighting where everything assumes a uniform grey, the person with one eye
Diet and Cancer – An Overview
Authors: Walter C. Willett, Brian MacMahon
Journal: New England Journal of Medicine (1984)

ALTHOUGH laboratory workers have known for decades that tumor incidence in animals can be affected by nutritional manipulation,1 the possibility that diet may be important in the cause and prevention of cancer in human beings has received major attention only recently. Since knowledge in this area is developing rapidly, we will outline processes by which hypotheses relating dietary factors to cancer are formulated and tested. In addition, we will discuss the limited available data that are relevant to some hypotheses that have attracted particular interest. An exhaustive review of the literature is contained in Diet. Nutrition, and Cancer, published . . .
Incision and Venous Patch Graft in the Surgical Treatment of Penile Curvature in Peyronie&amp;rsquo;s Disease
Authors: Emre Akkus, Hamdi Ozkara, Bulent Alici, Oktay Demirkesen, Akif Akaydin, Halim Hattat, Vural Solok
Journal: European Urology (2001)
A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome
Authors: Pierre Fenaux, Azra Raza, Ghulam J. Mufti, Carlo Aul, Ulrich Germing, Hagop Kantarjian, Larry Cripe, René Kerstens, Peter De Porre, Razelle Kurzrock
Journal: Blood (2007)
Association of the INS VNTR with size at birth
Authors: David B. Dunger, Ken K.L. Ong, Stewart J. Huxtable, Andrea Sherriff, Kathryn A. Woods, Marion L. Ahmed, Jean Golding, Marcus E. Pembrey, Sue Ring, None the ALSPAC Study Team, Simon T. Bennett, John A. Todd
Journal: Nature Genetics (1998)
Severe acute thrombocytopenia following infusion of plasma containing anti P1<sup>A1</sup>
Authors: Tirath S. Nijjar, Ines A. Bonacosa, Lyonel G. Israels
Journal: American Journal of Hematology (1987)

Abstract An 18‐year‐old girl with a preoperative platelet count of 216,000/cmm received 3 units of stored plasma at the time of surgery. Within 6 hours her platelet count had fallen to 5,000/mm 3 and hemorrhagic manifestations appeared. One of the plasma donors was found to be P1 A1 negative with an anti P1 A1 antibody. The recipient, who was P1 A1 positive, recovered normal platelet counts by day 8 post plasma infusion.
UNION IN VITRO OF THE PAPILLOMA VIRUS AND ITS ANTIBODY
Authors: William F. Friedewald, John G. Kidd
Journal: The Journal of Experimental Medicine (1940)

Experiments are described which show that the rabbit papilloma virus elicits an antibody of one type only, this being capable both of neutralizing the virus and of fixing complement in mixture with it. The virus and its antibody have a powerful, specific affinity for one another, each being capable of absorbing the other in great excess when they are brought together in the test tube. The union formed by them in vitro cannot be dissociated in any demonstrable degree by dilution or centrifugation. In many respects the findings differ from those with most viruses previously studied.
Whipple’s Disease — Rare Malady with Uncommon Potential
Authors: Robert M. Donaldson
Journal: New England Journal of Medicine (1992)

The general public often wonders why academic medicine focuses so much of its energy on rare diseases when many much more common disorders cry out for attention. Whipple's disease is an excellent example. Dobbins points out in his rigorously documented monograph1 that only 617 cases from around the world were reported between 1907 and 1986, and his wide-ranging inquiries over many years yielded only another 79 unreported cases. One reason that Whipple's disease, despite its rarity, deserves the attention it gets is practical. Physicians need to keep this disease constantly in mind to be able to recognize a patient with . . .
Systematic review of role of polymerase chain reaction in defining infectiousness among people infected with hepatitis C virus
Authors: G. J Dore, J. M Kaldor, G. W McCaughan
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To assess the role of polymerase chain reaction in defining infectiousness among people infected with hepatitis C virus. <b>Design:</b> Published studies of hepatitis C transmission were examined. Twenty nine studies with identified sources of hepatitis C infection who were tested for presence of hepatitis C RNA by polymerase chain reaction were reviewed, including studies of vertical transmission (n=21), transmission after transplantation (n=3), transfusion of blood components (n=3), and needlestick exposure (n=2). <b>Subjects:</b> All patients identified in studies. <b>Results:</b> A total of 2022 people who had been exposed to sources positive for antibody to hepatitis C were identified. Among 1148 people exposed to sources positive by polymerase chain reaction 148 cases of transmission occurred compared with no definite case among 874 people exposed to negative sources. Rates of transmission from positive sources were 6.2% for perinatal exposure, 6.1% after needlestick exposure, 78% after solid organ or bone marrow transplantation, and 83% after transfusion of blood components. Other factors influencing risk of vertical transmission were coinfection with HIV and level of hepatitis C viraemia. <b>Conclusions:</b> Negative results by polymerase chain reaction indicate an extremely low probability of transmission of hepatitis C from a person with antibody to hepatitis C. <h3>Key messages</h3> Between 20% and 50% of people infected with hepatitis C virus do not progress to chronic infection Polymerase chain reaction can detect ongoing hepatitis C viraemia and thus the presence of chronic infection The risk of transmission from people who are positive for hepatitis C antibody but have negative results by polymerase chain reaction is extremely low The rate of transmission from people who are positive for hepatitis C antibody and have positive results by polymerase chain reaction varies from 6% for mother to child transmission and occupational exposure to about 80% after transplantation or transfusion of blood components Polymerase chain reaction should be used to define infectiousness among people who are positive for antibodies to hepatitis C
Zoon's (plasma-cell) balanitis: treatment by circumcision
Authors: T.S. SONNEX, R.P.R. DAWBER, T.J. RYAN, I.G. RALFS
Journal: British Journal of Dermatology (1982)

SUMMARY Though circumcision has long been known to cure Zoon's balanitis, this mode of treatment has been largely neglected by many leading authorities in recent times. In this report we describe two patients who failed to respond to recommended topical treatment but who were rapidly cured by circumcision.
Critical Pulmonary Stenosis with a Diminutive Right Ventricle in Neonates
Authors: MICHAEL D. FREED, AMNON ROSENTHAL, WILLIAM F. BERNHARD, S. BERT LITWIN, ALEXANDER S. NADAS
Journal: Circulation (1973)

Thirteen of 19 neonates seen in the first months of life with critical pulmonary stenosis (PS) and an intact ventricular septum had a diminutive right ventricle (RV) evidenced by electrocardiographic and angiocardiographic criteria. All were critically ill and at catheterization had hypoxemia secondary to right-to-left shunting at the atrial level, and RV hypertension. Right ventricular angiogram was useful to evaluate RV size and differentiate the children with PS from those with pulmonary atresia. Pulmonary valvulotomy was the procedure of choice and in ten children the operation resulted in marked improvement with disappearance of cyanosis and cardiomegaly within one year. All are well six months to eight and one half years later. Two children had an additional unrecognized infundibular stenosis and required a shunt after valvulotomy because of persistant cyanosis. One child had a shunt without valvulotomy and died three years later in congestive failure. The three children who have been recatheterized at two to three years postoperatively have RV pressures less than 60 mm Hg. In two the right ventricles more than doubled in size but remain small. These children are critically ill and a good salvage rate depends on rapid evaluation and valvulotomy.
Diseases of the Veins
Authors: John Homans
Journal: New England Journal of Medicine (1946)

IN A previous review,1 evidence by pathologists for the origin of venous thrombosis below the knees was presented. Serious illnesses, especially cardiac, injuries, operations and childbirth were proved to be the usual background for thrombosis, much of which was terminal and unnoticed clinically. The state of the blood platelets following childbirth and surgical operations was shown to predispose toward thrombosis, and patients might be more or less liable to it, as indicated by their tolerance for or sensitivity to heparin. Local conditions in the lower limbs, however, appeared to be more important factors than any others. Early ambulation did not . . .
Gastrointestinal Infections in AIDS
Authors: Phillip D. Smith, Thomas C. Quinn, Warren Strober, Edward N. Janoff, Henry Masur
Journal: Annals of Internal Medicine (1992)

As the largest lymphoid organ in the body, the gastrointestinal tract is a potential reservoir for human immunodeficiency virus (HIV), the causative agent of the acquired immunodeficiency syndrome (AIDS), and it is an important site for HIV-induced immunodeficiency. The resulting defects in cellular and humoral defense mechanisms predispose the gastrointestinal tract to a spectrum of viral, fungal, bacterial, and protozoan pathogens that cause relentless morbidity and, in some cases, death. With a thorough diagnostic evaluation, physicians can identify one or more of these pathogens in a majority of patients with AIDS who have gastrointestinal symptoms. The identification of enteric pathogens in patients with AIDS is important because an increasing array of therapeutic regimens is becoming available to treat many of these infections.
Medicine as Ecoculture
Authors: Muriel R. Gillick
Journal: Annals of Internal Medicine (2009)

The use of diagnostic tests, especially imaging studies, varies markedly across the United States—with higher costs but no better patient outcomes associated with the highest-use regions. A proposed new model of the health care system draws on an analogy with the ecosystem to explain the geographic variations in physician test ordering. This framework emphasizes the adaptability and interdependence of the components of the system. Patients and physicians are influenced by the health care organizations in their community, including the practice site in which the physician works, local hospitals, malpractice lawyers, and imaging centers. These are in turn influenced by institutions in society at large, including the media, health care plans, and the government. Further adaptations to the explanatory model account for the psychologic and sociologic aspects of physician behavior. Understanding the medical ecoculture is essential for effective health care reform because widely touted changes, such as the introduction of an electronic medical record or comparative effectiveness studies, do not address the adaptability and interdependence that characterize the medical ecoculture.
The relative power of linkage and association studies for the detection of genes involved in hypertension
Authors: Hywel B. Jones
Journal: Kidney International (1998)

Hypertension is a common disorder that shows a polygenic mode of inheritance. Attempts to localize genes involved in the disorder have been carried out using both linkage and association tests. The relative merit of these two approaches is reviewed with an assessment of their utility for detecting genes involved in hypertension. Power calculations were carried out following the method of Risch and Merikangas [1], assuming markers were typed across the genome. These show that, if there is a single major locus causing susceptibility, non-parametric linkage strategies using affected sibpairs may well prove very effective. However, if there are a number of genes of small effect, the sample size necessary for linkage studies will be prohibitive and a systematic search for allelic association may be more appropriate. This is due to the dramatic reduction in the excess allele sharing for genes of small effect.
Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model
Authors: Sara Dossena, Luca Imeri, Michela Mangieri, Anna Garofoli, Loris Ferrari, Assunta Senatore, Elena Restelli, Claudia Balducci, Fabio Fiordaliso, Monica Salio, Susanna Bianchi, Luana Fioriti, Michela Morbin, Alessandro Pincherle, Gabriella Marcon, Flavio Villani, Mirjana Carli, Fabrizio Tagliavini, Gianluigi Forloni, Roberto Chiesa
Journal: Neuron (2008)
THE INFLUENCE OF DOSAGE AND ROUTE OF INJECTION ON THE ANTIBODY RESPONSE OF HUMAN SUBJECTS TO THE SPECIFIC CARBOHYDRATE OF THE TYPE VIII PNEUMOCOCCUS 1
Authors: James M. Ruegsegger, Maxwell Finland
Journal: Journal of Clinical Investigation (1935)

The readiness with which immune bodies could be demonstrated in human subjects following the injection of the specific carbohydrate of the Type VIII pneumococcus (1) offered an opportunity to study, in man, the effect of dosage and of the route of injection upon antibody production with a carbohydrate antigen.Although numerous in- vestigators have made similar studies with whole bacterial antigens in lower animals and in man, no data are available concerning the comparative antigenic activity, in man, of purified bacterial fractions given in different amounts or by dif- ferent routes.The development of antibodies following injections of type-specific polysaccarides was first demonstrated by Francis and Tillett (2) in the course of their investigations on cutaneous reactions in lobar pneumonia. EXPERIMENTAL Subjects, materials and methodsThe subjects chosen for this investigation, the Type VIII pneumococcus specific carbohydrate used, and the methods employed for the antibody studies have been de- scribed in the previous communication (1).Except in the subjects included in that report, phagocytic tests were performed irregularly.Only the results of the tests for agglutinins and mouse protective antibodies, therefore, will be considered here.
748 EFFECT OF B3-ADRENOCEPTOR MODULATION ON PORTAL PRESSURE IN RATS WITH COMPENSATED CIRRHOSIS
Authors: F. Giannone, M. Domenicali, P. Caraceni, V. Vasina, R. Latorre, M. Baldassarre, A. Berzigotti, M. Zoli, F. De Ponti, M. Bernardi
Journal: Journal of Hepatology (2009)
Possible pathophysiology of torsade de pointes evaluated by a realistic heart computer model
Authors: M. MALIK, A J. CAMM
Journal: Cardiovascular Research (1986)

Journal Article Possible pathophysiology of torsade de pointes evaluated by a realistic heart computer model Get access MAREK MALIK, MAREK MALIK **From the Department of Computer Science, Charles University, Prague Search for other works by this author on: Oxford Academic PubMed Google Scholar A JOHN CAMM A JOHN CAMM †From the Department of Cardiology, St Bartholomew's Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 20, Issue 6, June 1986, Pages 436–443, https://doi.org/10.1093/cvr/20.6.436 Published: 01 June 1986