tbuckley/cabot-search huggingface dataset:
South African healthcare professionals march for better pay and conditions
Authors: P. Sidley
Journal: BMJ (2009)

Thousands of public sector healthcare professionals and emergency services workers in South Africa took part in demonstrations throughout the country last week to protest about low salaries and poor working conditions.

Marches organised by the South African Medical Association took place in KwaZulu-Natal and the Eastern Cape. And Johannesburg’s emergency services workers shut down the city’s ambulance and fire services, claiming the council had failed to deliver on promised salary rises.

In Pretoria, joined by sympathetic colleagues in private practice, about 4000 doctors headed for the offices of the new health minister, Aaron Motsoaledi, who is the third person to occupy the post in a year.

Dr Motsoaledi acknowledged the problem but did not commit himself to meeting all their demands. Doctors want average pay rises of 50%. A doctor in the first year of practice and saddled with loans earns less than 19 000 rand (£1500; €1700; $2400) a month before deductions. This goes up only marginally in a further compulsory two year period of national service and subsequently fails to acknowledge experience or length of service.

Doctors also want an overhaul of the entire …
The Service Team in a Coordinated Home Care Program
Authors: Eva Reese
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Community nursing agencies provide the great bulk of continuing care for the sick at home, either in visiting nurse (voluntary) or health department (official) services. In a coordinated home care program, the public health nurse in many communities is literally "as close as your telephone." It is common practice for home care coordinators to speed the process of getting service to patients by a telephone call, followed by a written referral including the physician's signed orders. Most physicians expect the public health nurse to do more for the sick patients than carry out their written orders. The nurse is the most frequent professional visitor in the home and, for some people, the only continuing visitor. It becomes the nurse's job to serve the patient and help both patient and family understand and cope with the illness. Physicians commonly find that patients with cardiac disease and their families
Nonuniform recovery of excitability in the left ventricle.
Authors: J A Vassallo, D M Cassidy, K E Kindwall, F E Marchlinski, M E Josephson
Journal: Circulation (1988)

The purpose of this study was to determine left ventricular activation, dispersion of refractoriness, and total recovery time in patients with coronary artery disease and ventricular tachycardia and in patients with the long QT syndrome and to compare these patients with a group of normal patients. Left ventricular endocardial catheter mapping and left ventricular refractory period determination were performed in 18 patients. Group 1 consisted of seven patients with no heart disease and no arrhythmia; group 2 consisted of six patients with previous infarction and sustained ventricular tachycardia; and group 3 consisted of five patients with prolonged QT interval and previous cardiac arrest. Total left ventricular endocardial activation was significantly longer in group 2 (75 +/- 23 msec, mean +/- SD) compared with group 1 (34 +/- 9 msec, p less than 0.01) and group 3 (42 +/- 5 msec, p less than 0.05). Dispersion of refractoriness was significantly greater in group 3 (87 +/- 27 msec) than in group 1 (40 +/- 14 msec, p less than 0.01) and group 2 (53 +/- 14 msec, p less than 0.05). Dispersion of total recovery time was significantly greater in group 2 (90 +/- 30 msec) than in group 1 (52 +/- 14 msec, p less than 0.05) as well as group 3 (114 +/- 43 msec) compared with group 1 (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Needlestick Injuries Among French Medical Students
Authors: E. Rosenthal
Journal: JAMA (1999)

Of 237 registered students, 200 (84%) completed the questionnaire. The overall prevalence of BEA exposure was 24%, with 37% of sixth-year students reporting at least 1 BEA. The mean number of BEAs per student was 1.4. Wound suturing and arterial puncture for blood gas studies accounted for 58% and 20% of BEAs, respectively. The remaining 22% of the cases occurred during intramuscular (2 BEAs), intravenous (2 ) or lumbar (2 ) puncturing, and other procedures (5). Of students who recalled having experienced a BEA, 39% had reported the incident to hospital personnel. Students most frequently indicated their inability to influence the outcome (40%) as the reason for not reporting a BEA. Several students reported that they did not know whom to consult (20%) or had been advised against reporting (20%). Only 19% of students reported never recapping needles and always using a sharps container (TABLE). The decision to wear gloves was influenced by the procedure; most students used gloves for suturing, but not for intradermal or intramuscular injections. Of the students, 87% reported having received no information about universal precautions or BEAs during rotations. Discussion
Abstract 3780: Tumorigenicity and partial clear cell conversion of the epithelioid, but not fibroblastoid, subset of a sarcomatoid renal carcinoma cell line.
Authors: Chin-Hsuan Hsieh, Hung-Chang Chen, Cheng-Keng Chuang, See-Tong Pang, Ying-Hsu Chang, Shuen-Kuei Liao
Journal: Cancer Research (2013)

Abstract The biology of sarcomatoid renal cell carcinoma (RCC) and its conversion from and to the clear cell RCC cells are not fully understood. In this study, we analyzed the sarcomatoid RCC cell line, RCC52, derived from a clear cell RCC lesion with extensive sarcomatoid differentiation. When grown as monolayers, RCC52 cells consisted of mostly epithelioid cells and partly fibroblastoid cells, and were all PAX-2 negative, suggestive of in vitro growth of the sarcomatoid, but not clear cell, component. Immunohistology of xenografts resulted from subcutaneous injection of tumor cells revealed that only the parental line and all epithelioid sublines tested could develop solid tumors consisting of mostly sarcomatoid cells and PAX-2+ clear cells in areas. Our findings revealed (i) the coexistence of the two phenotypically distinct epithelioid and fibroblastoid subsets in this sarcomatoid RCC52 cell line, (ii) the dissociation of the abilities to display tumorigenicity and migratory/invasive potential by the epithelioid and fibroblastoid subsets, respectively, (iii) the capability of only epithelioid subset to undergo partial conversion to a clear cell type, and (iv) the identification of epithelioid subset as the niche for cancer stem cells within the RCC52 cell line. Importantly, using CD44 and CD24 markers in cytofluorometric analysis, we identified the phenotypes of the epithelioid and fibroblastoid subsets to be CD44+/CD24− and CD44+/CD24+, respectively. Collectively, our findings highlight the phenotypical and functional properties of the two distinct subsets in a sarcomatoid RCC. Thus, improved understanding of tumor heterogeneity, metastatic niche and stromal progression has profound consequence of metastatic disease, and promises to open up new strategies for therapy of cancer. Citation Format: Chin-Hsuan Hsieh, Hung-Chang Chen, Cheng-Keng Chuang, See-Tong Pang, Ying-Hsu Chang, Shuen-Kuei Liao. Tumorigenicity and partial clear cell conversion of the epithelioid, but not fibroblastoid, subset of a sarcomatoid renal carcinoma cell line. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3780. doi:10.1158/1538-7445.AM2013-3780
Cadmium, lead and zinc in growing rats fed corn leaf tissue grown on soil amended with sewage sludge or heavy metal salts.
Authors: J Miller, F C Boswell
Journal: Environmental Health Perspectives (1981)

Rats were fed, from weaning through 11 weeks of age, dried leaf tissue of corn plants grown on soil amended with regular NPK fertilizer (150-22-62), with 33.6 ad 67.2 metric ton/ha of sewage sludge or with salts of cadmium (10kg/ha), lead (25kg/ha), and/or zinc (50kg/ha). A very high proportion of the cadmium (cd) consumed was eliminated in feces. Only in rats fed diets containing leaf tissue from plants grown on soil to which CdCl2 salt or the high level of sludge had been added did the metal accumulate in significantly greater quantity than in rats fed a standard diet without leaf tissue. Most of the carcass accumulation of Cd could be accounted for by that in the liver and kidneys. The proportion of dietary zinc (Zn) that was excreted in feces was less than that for Cd, indicating that more Zn was absorbed into the body. There was no correlation between intake and accumulation of Zn in the tissues, however, so that much of the absorbed Zn must have been eliminated in some way. Fecal elimination did not serve as a way to rid the body of excessive intake of lead (Pb). However, with intakes ranging from 2 to 11 mg total in this study, the carcass load did not exceed 1.1 mg of Pb. Thus absorbed Pb, like Zn, must also be eliminated efficiently. No gross signs of toxicity or of physiological impairment were observed in rats fed any of the plant tissue samples.
Methysergide-induced heart disease: a case of multivalvular and myocardial fibrosis.
Authors: J W Mason, M E Billingham, J P Friedman
Journal: Circulation (1977)

Methysergide (Sansert) is known to cause mitral and aortic valvular fibrosis and dysfunction, but has generally not been known to damage right heart valves or the myocardium, and cardiac fibrosis has not been considered to be a risk if therapy is intermittently interrupted. The woman who is the subject of this case report developed catheterization-proven severe tricuspid and moderate aortic and mitral regurgitation during noncontinuous therapy with methysergide. In addition, right ventricular endomyocardial biopsy revealed extensive endocardial and intramyocardial fibrosis.
P1056 CHARACTERIZATION OF A NATURALLY OCCURRING REPLICATION-COMPETENT DEFECTIVE INTERFERING-LIKE HEPATITIS D VIRUS RNA LACKING BOTH RIBOZYME SITES
Authors: C.W. Hsu, M. Chao, Y.C. Chen, M.L. Chang, S.F. Huang, C.T. Yeh
Journal: Journal of Hepatology (2014)
If language is a jungle, why are we all cultivating the same plot?
Authors: Maggie Tallerman
Journal: Behavioral and Brain Sciences (2009)

Abstract Evans &amp; Levinson (E&amp;L) focus on differences between languages at a superficial level, rather than examining common processes. Their emphasis on trivial details conceals uniform design features and universally shared strategies. Lexical category distinctions between nouns and verbs are probably universal. Non-local dependencies are a general property of languages, not merely non-configurational languages. Even the latter class exhibits constituency.
Development of a New Method for Monitoring Prostate-Specific Antigen Changes in Men with Localised Prostate Cancer: A Comparison of Observational Cohorts
Authors: Kate Tilling, Hans Garmo, Chris Metcalfe, Lars Holmberg, Freddie C. Hamdy, David E. Neal, Jan Adolfsson, Richard M. Martin, Michael Davis, Katja Fall, J. Athene Lane, Hans-Olaf Adami, Anna Bill-Axelson, Jan-Eric Johansson, Jenny L. Donovan
Journal: European Urology (2009)
How Satisfying Is the Practice of Internal Medicine?
Authors: Charles E. Lewis, Deborah M. Prout, Elizabeth Prewitt Chalmers, Barbara Leake
Journal: Annals of Internal Medicine (1991)

To survey members of the American College of Physicians about their level of satisfaction and sources of dissatisfaction with practice, the extent to which their satisfaction is reflected in their counseling of students about careers in internal medicine, the prevalence of their concerns about patients' access to care, and their attitudes toward changes in the health care system.A questionnaire survey of a random sample of members of the College.Members (2254) of the College were surveyed; 1446 (64%) responded and 1290 (57%) of the responses were usable.More than 80% of respondents were satisfied with their relationships with patients, professional challenges, and opportunities to interact with colleagues. Only about half were satisfied with their potential income, and most were dissatisfied with their autonomy or loss of control over clinical decision making. Major sources of concern were administrative burdens, the threat of malpractice litigation, loss of income, and loss of clinical autonomy. Forty percent of internists say that they discourage students from careers in internal medicine, and only 39% would once again pursue such a career. "Pain in the practice" seems generalized among internists: logistic regression analysis failed to show any specific groups who were most dissatisfied or concerned. With regard to access, 18% of internists had many patients without health care insurance; 69% had some patients without coverage; and the majority (61%) had some patients who lost their insurance because of changing jobs or location. Assuring universal access to care received the highest priority rating of a set of criteria for health care reform.There is growing dissatisfaction with the practice of internal medicine, primarily related to concerns over loss of clinical autonomy, the increase in administrative burdens, the potential loss of income, and the threat of malpractice litigation. Although physicians are concerned about patients' access to care, proposals to improve access should be examined for their effects on the major sources of physicians' dissatisfaction with practice.
Letter: Renal lesions of subacute infective endocarditis.
Authors: D E Powell
Journal: BMJ (1974)

published in the near fuutre.6The pre- liminary results of in vitro lipid haemodialysis utilizing '4C-imipramine indicate a clearance of approximately 20 to 40 ml/min, depending on the type of filter, dialysate, and blood-line system used.-Weare, etc.,
Correction: Study of Granulocyte Transfusion
Authors: ROBERT PETER GALE
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 December 1981Correction: Study of Granulocyte TransfusionROBERT PETER GALE, M.D., PH.D.ROBERT PETER GALE, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-6-786_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent study from UCLA, of which I was a coauthor, analyzed prophylactic granulocyte transfusions in neutropenic patients with acute myelogenous leukemia (1). The article should have indicated that most of the UCLA patients also participated in a national study collaboratively designed by investigators from the University of Iowa (R. G. Strauss), the University of Minnesota (C. D. Bloomfield, J. E. Connett, and J. McCullough), Washington University (G. P. Herzig), and UCLA. Results of the national study have been published recently (2)....References1. WINSTONHOGALE DWR. Prophylactic granulocyte transfusions during chemotherapy of acute nonlymphocytic leukemia. Ann Intern Med. 1981;94:616-22. LinkGoogle Scholar2. STRAUSSCONNETTGALE RJR. A controlled trial of prophylactic granulocyte transfusions during initial induction chemotherapy for acute myelogenous leukemia. N Engl J Med. 1981;305:597-603. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: UCLA School of Medicine Los Angeles, CA 90024 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1981Volume 95, Issue 6Page: 786-786KeywordsAcute myeloid leukemiaGranulocytes ePublished: 1 December 2008 Issue Published: 1 December 1981 PDF downloadLoading ...
P2-162: Phase I trial of gefitinib in combination with concurrent carboplatin, paclitaxel and radiation therapy in patients with stage III non small cell lung cancer (“CRITICAL”)
Authors: David Ball, Bryan Burmeister, Paul Mitchell, Michael Boyer, Michael Mac Manus, Euan Walpole, Malcolm Feigen, Mo Mo Tin, Danny ischin
Journal: Journal of Thoracic Oncology (2007)
Quality of care in frail older people: the fragile balance between receiving and giving
Authors: M. Vernooij-Dassen, S. Leatherman, M. Olde Rikkert
Journal: BMJ (2011)

The focus on providing essential medical and social care for frail older people often leaves them feeling unable to contribute. But building in reciprocation could help preserve social inclusion and foster autonomy, dignity, and quality of life, say <b>Myrra Vernooij-Dassen</b>, <b>Sheila Leatherman</b>, and <b>Marcel Olde Rikkert</b>
Species of the toxic Pfiesteria complex, and the importance of functional type in data interpretation.
Authors: J M Burkholder, H B Glasgow, N J Deamer-Melia, J Springer, M W Parrow, C Zhang, P J Cancellieri
Journal: Environmental Health Perspectives (2001)

We describe the two species of the toxic Pfiesteria complex to date (Pfiesteria piscicida and Pfiesteria shumwayae), their complex life cycles, and the characteristics required for inclusion within this complex. These species resemble P. piscicida Steidinger & Burkholder and also have a) strong attraction to fresh fish tissues and excreta, b) toxic activity stimulated by live fish, and c) production of toxin that can cause fish death and disease. Amoeboid stages were verified in 1992-1997 by our laboratory (various stages from toxic cultures) and that of K. Steidinger and co-workers (filose amoebae in nontoxic cultures), and in 2000 by H. Marshall and co-workers (various stages from toxic cultures), from clonal Pfiesteria spp. cultures, using species-specific polymerase chain reaction-based molecular probes with cross-confirmation by an independent specialist. Data were provided from tests of the hypothesis that Pfiesteriastrains differ in response to fresh fish mucus and excreta, algal prey, and inorganic nutrient (N, P) enrichment, depending on functional type or toxicity status. There are three functional types: TOX-A, in actively toxic, fish-killing mode; TOX-B, temporarily nontoxic, without access to live fish for days to weeks, but capable of toxic activity if fish are added; and NON-IND, noninducible with negligible toxicity in the presence of live fish. NON-IND Pfiesteria attained highest zoospore production on algal prey without or without inorganic nitrogen or inorganic phosphorus enrichment. TOX-B Pfiesteria was intermediate and TOX-A was lowest in zoospore production on algal prey with or without nutrients. TOX-A Pfiesteria spp. showed strong behavioral attraction to fresh fish mucus and excreta in short-term trials, with intermediate attraction of TOX-B zoospores and relatively low attraction of NON-IND cultures when normalized for cell density. The data for these clones indicated a potentially common predatory behavioral response, although differing in intensity distinct from a toxicity effect, in attack of fish prey. The data also demonstrated that functional types of Pfiesteria spp. show distinct differences in response to fish, algal prey, and inorganic nutrient enrichment. Collectively, the experiments indicate that NON-IND strains should not be used in research to gain insights about environmental controls on toxic strains of Pfiesteria spp.
Research funding in complementary medicine
Authors: B.-Y. Ma
Journal: Journal of the Royal Society of Medicine (2005)

Professor Ernst (October 2004 JRSM1) believes the UK Department of Health to be misguided in funding isolated postdoctorate fellowships in complementary medicine rather than 'centres of excellence' such as his own in Exeter. In my opinion, individual funding is the better route for people who wish to do practical research. The meta-analyses that represent a large part of the output of the Exeter centre certainly need to be done, but in many instances such studies ought to be conducted as preliminaries to new work in the laboratory or clinic. Professor Ernst's centre has also reported randomized trials, but there are dangers in conducting these from a centre dealing with 'complementary' techniques in general rather than in particular. Sometimes these have come under severe criticism from complementary practitioners. From my specialist knowledge of acupuncture, I have expressed grave doubts about the design and conclusions from one of the trials published from the Exeter unit.2 In terms of quality, the Department of Health may have chosen the best course.
Morphometric and histochemical investigation on human right atrial and mitral papillary muscle
Authors: P. G. I. STOVIN, J. P. REED
Journal: Cardiovascular Research (1973)

Right auricular and mitral papillary muscles from eight patients undergoing open heart normothermic prosthetic valve insertions were studied morphometrically and with a battery of histochemical staining reactions. Monoamine oxidase (MAO) and β hydroxybutyrate dehydrogenase (βHBD) activities were greater in the papillary than auricular muscles, while succinic dehydrogenase (SD), calcium activated adenosine triphosphatase (ATPase) and glucose-6-phosphate dehydrogenase (G6PD) were more active in the auricular than papillary muscles irrespective of the degrees of hypertrophy in these muscles. There was some indication that in the auricle there was a relationship between hypertrophy and an increase in aldolase (Ald) activity.
Quantification of infarction in cross sections of canine myocardium in vivo with positron emission transaxial tomography and 11C-palmitate.
Authors: E S Weiss, S A Ahmed, M J Welch, J R Williamson, M M Ter-Pogossian, B E Sobel
Journal: Circulation (1977)

To assess myocardial infarction quantitatively in 15 mm thick transverse sections of the canine heart in vivo we utilized a new technique, positron emission transaxial tomography (PETT) and cyclotron-produced 11C-palmitate (11C-P) injected intravenously. Results were compared to regional myocardial creatine phosphokinase (CPK) depletion, diminished 14C-palmitate accumulation in tissue extracts, and infarction estimated morphometrically 48 hours after coronary occlusion. CPK activity and 14C-P content declined in parallel in transmural biopsies (N=44) from normal and ischemic zones (r=.92) in six dogs; and infarct in 10 mm thick cross sections of the entire left ventricle estimated morphometrically (N=26) in six other animals correlated with CPK depletion in contiguous 2.5 mm thick slices (r=.92). When the percentage of infarction in 15 mm thick cross sections was assessed tomographically in six other dogs 48 hours after coronary occlusion with 11C-P injected intravenously, results correlated with infarction in corresponding cross sections from the same hearts estimated morphometrically (r=.97, N=9) and by analysis of CPK depletion (r=.93, N=9). Thus, PETT permits estimation of infarction in cross sections of the left ventricle in vivo after intravenous injection of 11C-palmitate.