Gamma Globulin and Non-A Type Hepatitis
Authors: Marcel E. Conrad, Robert G. Knodell
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 July 1978Gamma Globulin and Non-A Type HepatitisMARCEL E. CONRAD, M.D., ROBERT G. KNODELL, M.D.MARCEL E. CONRAD, M.D.Search for more papers by this author, ROBERT G. KNODELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-1-141 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the March issue the VA Cooperative Study Group elegantly showed that hepatitis B immune globulin (HBIG) is superior to immune serum globulin (ISG) in preventing hepatitis type B among persons exposed by needle stick to HBsAG (1). However, they incorrectly stated that it was impossible to determine whether ISG has any efficacy in the prevention of hepatitis type B because a non-gamma globulin placebo has not been used in any clinical trial. The first gamma globulin trial in which HBsAg testing was available was a randomized, double-blind study of 107 803 subjects in which the efficacy...References1. SEEFFWRIGHTZIMMERMANALTERDIETZFELSHERFINKELSTEINGARCIA-PONTGERINGREENLEEHAMILTONHOLLANDKAPLANKIERNANKOFFLEEVYMCAULIFFENATHPURCELLSCHIFFSCHWARTZTAMBURROVLAHCEVICZEMELZIMMON LEHHABJPJHJPPTRCVNRECCZRD: Type B hepatitis after needle-stick exposure: prevention with hepatitis B immune globulin. Final report of the Veterans Administration Cooperative Study. Ann Intern Med 88:285-293, 1978 LinkGoogle Scholar2. A Cooperative Study: prophylactic gamma globulin for the prevention of endemic hepatitis. Effects of U.S. gamma globulin upon the incidence of viral hepatitis and other infectious diseases in U.S. soldiers abroad. Arch Intern Med 128:723-738, 1971 CrossrefMedlineGoogle Scholar3. 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SEEFFZIMMERMANWRIGHTFELSHERFINKELSTEINGARCIA-PONTGREENLEEDIETZHAMILTONKOFFLEEVYKIERNANTAMBURROSCHIFFVLAHCEVICZEMELZIMMONNATH LHEBJPHAJRCTCEZRDN: Efficacy of hepatitis B immune serum globulin after accidental exposure. Preliminary report of the Veterans Administration Cooperative Study. Lancet 2:939-941, 1975 CrossrefMedlineGoogle Scholar2. TABORGERETYDRUCKERSEEFFHOOFNAGLEJACKSONAPRILBARKERPINEDA-TAMONDONG ERJLJDMLG: Transmission of non-A, non-B hepatitis from man to chimpanzee. Lancet 1:463-466, 1978 CrossrefMedlineGoogle Scholar3. GRADYLEE GV: Prevention of hepatitis from accidental exposure among medical workers. N Engl J Med 293:1067-1070, 1975 CrossrefMedlineGoogle Scholar4. KRUGMANGILES SJ: Viral hepatitis, type B (MS-2-strain): further observations on natural history and prevention. N Engl J Med 288:755-760, 1973 CrossrefMedlineGoogle Scholar5. PRINCESZMUNESSMANNVYASGRADYSHAPIROSUKIFRIEDMANAVRAMSTENZEL AWMGGFWEMK: Hepatitis B immune globulin: final report of a controlled, multicenter trial of efficacy in prevention of dialysis-associated hepatitis. J Infect Dis 137:131-144, 1978 CrossrefMedlineGoogle Scholar6. SZMUNESSPRINCEGOODMANEHRICHPICKANSARI WAMCRM: Hepatitis B immune serum globulin in prevention of nonparenterally transmitted hepatitis B. N Engl J Med 290:701-706, 1974 CrossrefMedlineGoogle Scholar7. IWARSONAHLMENERIKSSONHERMODSSONKJELLMANLJUNGGRENSELANDER SJESHCD: Hepatitis B immune globulin in prevention of hepatitis B among hospital staff members. J Infect Dis 135:473-477, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1978Volume 89, Issue 1Page: 141-142KeywordsClinical trialsGlobulinsHepatitisHepatitis AHepatitis BImmune serumImmune serum globulin Issue Published: 1 July 1978 PDF downloadLoading ...