tbuckley/cabot-search huggingface dataset:
Supraventricular Tachycardia Complicating Surgical Procedures
Authors: WAYNE R. ROGERS, FELIX WROBLEWSKI, JOHN S. LADUE
Journal: Circulation (1953)

Persistent postoperative supraventricular tachycardia, despite adequate therapy, is a bad prognostic sign, and cardiac failure due to, or associated with, arrhythmia responds poorly to treatment. Of the 12 patients (24 per cent) resistent to therapy, eight developed congestive heart failure, with five dying as a result. The preoperative, intraoperative and postoperative factors contributing to the causes of this complication are reviewed, and the therapy, course and end results are discussed.
Cyclophosphamide and the bladder.
Authors: F R Glover
Journal: BMJ (1971)

fill this seat, the choice lies between a career grade officer, a general practitioner, or a hospital junior doctor with a number of house appointments behind him.If staffing is to be entirely by career grade officers, then the minimum number is five and not four as suggested by Mr. F. C. Durbin and Mr. J. S. Batchelor (14 August, p.
Educational Problems Accompanying the Increasing Institutionalization of Medicine
Authors: Glen R. Leymaster
Journal: New England Journal of Medicine (1964)

THE present time is surely the decade of the organization. If anything needs to be done a committee or a commission is appointed, or a pressure group or an association is organized, depending on the size of the problem. Medicine is no exception, and something of the scope of activities of several important organizations and institutions of medicine has already been described. That most of these are effective and generally useful, there can be no doubt. If, however, medical education is to rest securely on a foundation of education in medical schools, in hospitals and in the professional organizations representing . . .
Hemostasis and thrombosis in patients with liver disease: The ups and downs
Authors: Ton Lisman, Stephen H. Caldwell, Andrew K. Burroughs, Patrick G. Northup, Marco Senzolo, R. Todd Stravitz, Armando Tripodi, James F. Trotter, Dominique-Charles Valla, Robert J. Porte
Journal: Journal of Hepatology (2010)
Body composition of athletes in Bahrain.
Authors: A O Musaiger, M A Ragheb, G al-Marzooq
Journal: British Journal of Sports Medicine (1994)

A total sample of 304 athletes was selected from first class clubs related to four common sports (football, handball, volleyball and basketball) and compared with 53 non-athlete adults. Weight, height, mid-arm circumference and skinfold thickness were measured to assess their body composition. The findings revealed that there were differences in body composition among athletes according to the type of sport. Basketballers and volleyballers were the tallest athletes, while handballers were the heaviest ones. Skinfold thickness measurements showed that basketball and handball players have more subcutaneous fat than other athletic groups. As compared with non-athletes, the Bahraini players had higher means for height, weight, subscapular, suprailliac thickness and mid-arm circumference.
Indium-111 Pentetreotide Uptake Within Cerebellar Hemangioblastoma in Von Hippel-Lindau Syndrome
Authors: Fahmid U. Chowdhury, Andrew F. Scarsbrook
Journal: Clinical Nuclear Medicine (2008)

A 38-year-old woman with known von Hippel-Lindau syndrome underwent In-111 pentetreotide (OctreoScan) scintigraphy to evaluate a suspected pancreatic neuroendocrine tumor. The patient had undergone surgical resection of a left adrenal pheochromocytoma and a large right cerebellar hemangioblastoma several years previously. Although there was no evidence for recurrence of pheochromocytoma and no uptake within the pancreatic lesion, there was focal tracer accumulation within the left cerebellar hemisphere. MR imaging of the brain confirmed the presence of recurrent hemangioblastoma in the left cerebellum.
Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and [<sup>123</sup>I]Iomazenil
Authors: Anissa Abi-Dargham, John H. Krystal, Satish Anjilvel, Barbara Ellen Scanley, Sami Zoghbi, Ronald M. Baldwin, Nallakkandi Rajeevan, Steven Ellis, Ismene L. Petrakis, John P. Seibyl, Dennis S. Charney, Marc Laruelle, Robert B. Innis
Journal: American Journal of Psychiatry (1998)

Objective:Alterations in cortical benzodiazepine receptor density have been described in postmortem and in vivo studies of alcoholic subjects. The authors attempted to replicate these findings using single photon emission computed tomography and the benzodiazepine receptor radiotracer [123I]iomazenil. Method:They measured the distribution volume of benzodiazepine receptors in 11 recently detoxified patients with type II alcoholism and 11 healthy comparison subjects. The tracer was given as a bolus followed by a continuous infusion to achieve sustained binding equilibrium at the benzodiazepine receptors. Data were analyzed by using a region of interest method (regions of interest were identified on coregistered magnetic resonance imaging scans) and by a pixel-by-pixel method (distribution volume maps were analyzed with statistical parametric mapping for between-group differences).Results:The region of interest analysis revealed that alcoholic patients had significantly lower benzodiazepine distribution volume than comparison subjects in the frontal, anterior cingulate, and cerebellar cortices. Statistical parametric mapping revealed two large excursions in which the distribution volume in alcoholic patients was significantly lower than in comparison subjects: the anterior cingulate, extending into the right middle frontal gyrus, and the left occipital cortex. Conclusions:Benzodiazepine receptor distribution volume is significantly lower in several cortical regions and the cerebellum in alcoholic subjects than in healthy comparison subjects. These results are consistent with previous reports and might indicate either a toxic effect of alcoholism on benzodiazepine receptors or a vulnerability factor for developing alcoholism. Am J Psychiatry 1998; 155: 1550-1555
Estrogen Trial for Patients with Endometrial Cancer
Authors: Andrew A. Skolnick
Journal: JAMA (1997)

TO RESOLVE the question of whether estrogen replacement therapy (ERT) is safe even for women who have had earlystage endometrial cancer, a multicenter randomized trial will begin enrolling patients this summer. The Gynecologic Oncology Group of the American College of Obstetricians and Gynecologists (ACOG), Washington, DC, hopes to enroll at least 2000 women in the National Cancer Institute (NCI)—sponsored ERT Study, said principal investigator Richard Barakat, MD. Speaking at ACOG's 45th annual meeting in Las Vegas, Nev, Barakat, who is an attending physician at Memorial Sloan-Kettering Cancer Center, New York, NY, called on all ACOG members and other physicians to help recruit for this study. In the past, ERT has not been recommended for postmenopausal women with a history of uterine cancer because of concern that the estrogen might increase the risk of recurrence, said Robert C. Park, MD, chair of the Gynecologic Oncology Group. "We now have no evidence
When the Heart Runs Out of Heartbeats
Authors: Tariq Ahmad, Chetan B. Patel, Carmelo A. Milano, Joseph G. Rogers
Journal: Circulation (2012)

A 50-year-old man was referred to the Advanced Heart Failure clinic at our institution for consideration of additional treatment options.He was diagnosed with heart failure (HF) 4 years earlier.Transthoracic echocardiography revealed a dilated left ventricle (LV) with an LV end-diastolic dimension of 5.5 cm, globally depressed ejection fraction (EF; estimated at 30%), and moderate mitral regurgitation.Complete blood cell count, urinalysis, and liver function tests were normal.Screening for hemochromatosis, human immunodeficiency virus, rheumatologic disease, and amyloidosis was performed and was negative.He did not have a family history of cardiomyopathy or sudden cardiac death.Coronary angiography revealed no evidence of obstructive coronary artery disease.Right heart catheterization demonstrated a right atrial pressure of 15 mm Hg, pulmonary artery pressure of 41/21 mm Hg, pulmonary capillary wedge pressure of 20 mm Hg, and cardiac index of 2.3 L ⅐ min ؊1 ⅐ m ؊2. He was started on evidence-based therapies for HF.An implantable cardioverter-defibrillator was placed for primary prevention of sudden cardiac death after no improvement in his EF.He was not considered a candidate for cardiac resynchronization therapy because his QRS duration was 100 milliseconds.He had progressive HF symptoms despite maximal medical therapy and was hospitalized 3 times during the 6 months before referral for acute decompensated HF.The doses of angiotensin-converting enzyme inhibitor and ␤-blocker had been recently reduced by his cardiologist secondary to lightheadedness and fatigue accompanied by hypotension.His medical history was remarkable for hypertension and dyslipidemia.He reported adherence to his prescribed medications that included carvedilol 6.25 mg twice daily, lisinopril 5 mg daily, spironolactone 25 mg daily, and furosemide 40 mg daily.
FRACTURE OF THE TIBIA AND FIBULA
Authors: Otto E. Aufranc
Journal: JAMA (1960)

Dr. J. H. Dimon: A 51-year-old maintenance man was admitted to the emergency ward of the Massachusetts General Hospital in November, 1958, one hour after being struck by an automobile. He was conscious and not in shock. The right leg, which had been wrapped in a pillow splint, revealed an open transverse fracture of the midshaft of the right tibia and fibula (fig. 1 and 2). The bone was exposed from the anterior tibial tubercle to 2 cm. above the ankle joint, and the skin was sleeved circumferentially over this area. Sensation and circulation were present in the foot, and the dorsalis pedis pulse was palpable; the posterior tibial pulse was absent. The wound was grossly contaminated with clothing and dirt, and there was little bleeding from the area. No other significant injuries were present. The patient had always been in excellent health prior to the accident. He had had
Abstract A56: Identification of a micro RNA profile to predict response to therapy and improve patient survival in ovarian cancer
Authors: Marina Rigau, Blanca Majem, Tatiana Altadill, Lucia Lanau, José-Luis Sánchez-Iglesias, Josep Castellví, Assumpció Pérez-Benavente, Silvia Cabrera, Angel García, Jordi Xercavins, Francesc Alameda, Xavier Matias-Guiu, Antonio Gil-Moreno, Josep-Maria Del Campo, Marta Llauradó, Jaume Reventós
Journal: Clinical Cancer Research (2013)

Abstract Introduction &amp; Objectives: Ovarian cancer (OC) is the leading cause of death among gynecological malignancies in developed countries. The standard treatment is surgery plus platinum-paclitaxel (CP/TX) chemotherapy. Nevertheless, 70% of these patients are diagnosed in advanced stages, and, among those, 75% will recur, become resistant to therapies and die. We believe that an improvement in OC survival might be related with an early identification of those patients, since long survival (SV) is related to chemosensitivity. Our aim is to identify an expression profile of micro RNAs (miRNAs) associated with SV of patients with advanced OC. Material &amp; Methods: Formalin-fixed paraffin-embedded (FFPE) primary tumor tissues from late stage (III/IV) OC patients were collected at the time of surgery for the study. All patients were treated with optimal surgery and standard chemotherapy (CP/TX; after surgery). Samples were divided into two groups; (a) patients with “long SV” (SV&amp;gt;10 years after diagnosis) and (b) patients with “short SV”. The identification of miRNAs associated with each profile of SV was performed using TaqMan Array MicroRNA microfluidic cards in 30 patients. Results: The identification phase has shown that the majority of the miRNAs appeared to be down-regulated in the group of “short SV” versus the “long SV”. A validation phase in a new group of tumor tissue samples is ready to validate the promising miRNA candidates that seem to be associated with the resistant (short SV) and the sensitive (long SV) profiles. Conclusions: The ability to identify markers associated with “long SV” in patients with advanced OC could allow transforming the impact of the disease through the reduction of chemotherapy treatments and the reduction of unnecessary health care costs. Moreover, it could permit the generation of knowledge applicable to the future development of new therapies for the “short SV” since they are supposed to be resistant to the therapy. Citation Format: Marina Rigau, Blanca Majem, Tatiana Altadill, Lucia Lanau, José-Luis Sánchez-Iglesias, Josep Castellví, Assumpció Pérez-Benavente, Silvia Cabrera, Angel García, Jordi Xercavins, Francesc Alameda, Xavier Matias-Guiu, Antonio Gil-Moreno, Josep-Maria Del Campo, Marta Llauradó, Jaume Reventós. Identification of a micro RNA profile to predict response to therapy and improve patient survival in ovarian cancer. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr A56.
SOME EXPERIENCES OF THE RECENT INFLUENZA EPIDEMIC IN BRISTOL
Authors: J. W. Taylor
Journal: BMJ (1919)

The method we have adopted consists in either spread ing a thick layer of the oleate ointment on a single thick ness of white gauze and then applying it to the wound, or spreading the oleate direct on to the surface of the wound and then covering it with a single layer of gauze. This dressing does not need to be changed for several days, and, when it is removed, strips off from the sensitive surface without any dragging or pain. It is equally applicable to any large flat-surfaced wounds, such as those left after wholesale excision of the thigh or buttock muscles, and so forth. We have used this dressing continuously until granula tion was complete; the process appeared to occur normally, no retardation or deficiency of formation of granulation tissue being observed. It has the advantage that it adheres sufficiently of-itself and requires no bandage or pad to retain it in contact with the, wound. The injured part can.therefore, except for its covering of proflavine oleate gauze, be left fully. exposed to the air. undpr a bed cradle covered with a layer of butter muslin. We would -suggest that after all operations in which a flat raw surface is necessarily left, the wound should, from the first, be dressed withl profiavine oleate, in the manner we describe.
Circadian variation of plaque rupture in patients with acute myocardial infarction
Authors: Atsushi Tanaka, Takahiko Kawarabayashi, Toshihiko Sano, Hiroki Oe, Yoshiharu Nishibori, Masashi Namba, Yukio Nishida, Daiju Fukuda, Kenei Shimada, Junichi Yoshikawa
Journal: Journal of the American College of Cardiology (2003)
The Ngal reporter mouse detects the response of the kidney to injury in real time
Authors: Neal Paragas, Andong Qiu, Qingyin Zhang, Benjamin Samstein, Shi-Xian Deng, Kai M Schmidt-Ott, Melanie Viltard, Wenqiang Yu, Catherine S Forster, Gangli Gong, Yidong Liu, Ritwij Kulkarni, Kiyoshi Mori, Avtandil Kalandadze, Adam J Ratner, Prasad Devarajan, Donald W Landry, Vivette D'Agati, Chyuan-Sheng Lin, Jonathan Barasch
Journal: Nature Medicine (2011)
Breast cancer detection rates increase but coverage varies
Authors: Lynn Eaton
Journal: BMJ (2005)

New methods of screening for breast cancer have led to an increase in the number of cancers detected in England, according to latest statistics from the Department of Health. But the data show that there is still wide geographical variation in the proportion of eligible women who have been screened in the past three years.

In 2003-4, the number of breast cancers detected increased by more than 14% compared with 2002-3. Of the 1.4 million women screened in England in 2003-4, 11 227 had cancer detected and treated compared with 9848 in 2002-3.

Nearly half of the cancers detected in …
Guidelines for anticoagulation
Authors: F Taylor, M Ramsay, A Renton, H Cohen
Journal: BMJ (1994)

the month after discharge the risk of suicide is increased over 100-fold.Approximately 2/8% of those presenting after parasuicide will have com- mitted suicide at eight year follow up.For those admitted to hospital the risk might be expected to be higher: 15% of patients admitted to hospital with depression commit suicide.3The introduction of more complex discharge procedures and the care programme approach have led to a greater concentration on patients who require admission to hospital and suffer severe mental illness.The lack of new resources to implement these time consuming procedures may lead to reduced provision for patients presenting in crisis.The lack of suicides in our cohort, despite important risk factors, illustrates the difficulties for secondary services in effectively targeting those at high risk of suicide.The Health of the Nation aims at reducing the rate of suicide by 15% overall and by 33% among people with serious mental illness.4In the absence of meaningful target groups, with limited and redirected resources we run the risk of targeting too specific a group, by default, and failing to meet those aims.
Does Passage of a Patency Capsule Indicate Small-Bowel Patency? A Prospective Clinical Trial?
Authors: M. L. Boivin, H. Lochs, W. A. Voderholzer
Journal: Endoscopy (2005)

At many centers wireless capsule endoscopy (WCE) without prior radiographic examination to rule out relevant strictures is considered to be contraindicated in suspected obstructive small-bowel disease. However, the accuracy of radiography in this situation has often been questioned. The purpose of this prospective study was to investigate the feasibility and safety of the recently developed patency capsule, and its predictive value regarding the clinical relevance of radiographic small-bowel strictures.22 patients with suspected obstructive small-bowel disease and/or radiological evidence of small-bowel strictures underwent a patency capsule examination. Intact passage, patient experience of pain, and capsule disintegration were correlated with radiographic findings, clinical variables, and outcome.13 patients passed an intact capsule without complaints, despite radiographically observed small-bowel stenosis; the subsequent video capsule examination was uneventful in all. In nine patients either intact passage was painful or the capsule disintegrated; in one of these, impaction of an intact capsule led to an ileus and emergency surgery. The type of capsule passage did not correlate with radiographic presence of a stricture, underlying diagnosis, or previous surgery. There was a statistically significant correlation between outcome (surgery performed or recommended) and occurrence of painful capsule passage and disintegration ( P < or = 0.05).Painless egestion of an intact patency capsule indicates safety of WCE. Patients without obstructive symptoms require neither small-bowel radiography nor a patency capsule study prior to WCE. Disintegration of the patency capsule or painful passage seems to be associated with a clinically relevant small-bowel stricture and with a high probability of surgery.
Excessive wave reflections on admission predict post‐discharge events in patients hospitalized due to acute heart failure
Authors: Shih‐Hsien Sung, Wen‐Chung Yu, Hao‐Min Cheng, Ching‐Wei Lee, Mei‐Mei Lin, Shao‐Yuan Chuang, Chen‐Huan Chen
Journal: European Journal of Heart Failure (2012)
Surgical Closure of the Ductus Arteriosus in Premature Infants
Authors: L. HENRY EDMUNDS, GEORGE A. GREGORY, MICHAEL A. HEYMANN, JOSEPH A. KITTERMAN, ABRAHAM M. RUDOLPH, WILLIAM H. TOOLEY
Journal: Circulation (1973)

During a 62-month period patent ductus arteriosus (PDA) was diagnosed in 88 premature infants with birth weights less than 1750 g. Twenty-one of these infants required operative closure of the PDA. Six infants had uncontrolled heart failure without associated pulmonary disease. Fifteen infants had severe idiopathic respiratory distress syndrome (IRDS) and required operation for deteriorating pulmonary function when heart failure developed. Twelve of these 15 infants weighed less than 1250 g at birth. The ductus arteriosus was ligated in 19 patients and was divided in two patients. The six infants without IRDS survived, and four are completely normal. Of 15 infants with IRDS eight had steady improvement in pulmonary function after operation. Three of these eight patients eventually died. In three infants pulmonary function improved slowly and in two patients pulmonary function did not improve after operation; all of these patients eventually died. Two patients died of peritonitis secondary to bowel ischemia. Of the five infants with IRDS who are alive, one is two months of age, two are moderately retarded in psychomotor development, and two, who developed hydrocephalus, are severely retarded. Although operation successfully controls heart failure in premature infants with PDA and IRDS, progressive pulmonary disease and the complications of extreme prematurity pre-empt good results in most of these infants.
The influence of chemical and physical forms of ambient air acids on airway doses.
Authors: T V Larson
Journal: Environmental Health Perspectives (1989)

The effects of ambient relative humidity and particle size on acid deposition within the airways have been examined with a computer model. For H2SO4 particles initially at 90% relative humidity in ambient air that are inhaled via the nose or mouth, there is significant deposition of acid in the airways even in the presence of typical values of respiratory NH3. When these same particles are found in a fog at 100.015% relative humidity, there is significant deposition of acid in the nasal region during nose breathing but insignificant deposition to the deep lung for either nose or mouth breathing. The factors governing the partitioning of labile acid gases in the gas and liquid phases prior to inhalation are also discussed.
Joseph Norman Blau
Authors: A. MacGregor
Journal: BMJ (2010)

Born in Berlin, Joseph Norman Blau (“Nat”) escaped to England at the start of the second world war. His Polish parents and sister were later captured and shot by the Nazis. Deciding to study medicine, he secured an open science scholarship to St Bartholomew’s Hospital Medical School. After national service, a Nuffield Medical Scholarship took him to Massachusetts General Hospital, Boston, where he studied the thymus. Returning to London, he continued his MD research on Hassall’s corpuscles at Guy’s Hospital, supported by an MRC grant, while also working as a consultant neurologist …
Indomethacin-induced asthma in aspirin-sensitive patients.
Authors: N M Johnson, A E Black, S W Clarke
Journal: BMJ (1977)

3) Dr Woodcock's point about the effect of the failure rate had been considered.In any experimentation on human subjects missing data from subject loss tend to occur; there is no way of completely overcoming this problem, either clinically or statistically.We believe our analysis provided the most reasoned assessment of the data by (1) analysing between group failure rates and (2) analysing the exist- ing data while explicitly acknowledging the possible effects of missing data.Furthermore, both sets of data are presented and both show small positive effects for antimicrobials, so there is little chance of the reader beirng misled.