tbuckley/cabot-search huggingface dataset:
Evidence that dysregulated DNA mismatch repair characterizes human nonmelanoma skin cancer
Authors: L.C. Young, J. Listgarten, M.J. Trotter, S.E. Andrew, V.A. Tron
Journal: British Journal of Dermatology (2007)

Background In addition to an established role in the repair of postreplicative DNA errors, DNA mismatch repair (MMR) proteins also contribute to cellular responses to exogenous DNA damage. Previously, we have shown that Msh2‐null mice display increased sensitivity to ultraviolet (UV) B‐induced tumorigenesis, but squamous cell carcinomas (SCC) generated are microsatellite stable, suggesting a role for MMR other than postreplicative repair in UV‐induced cutaneous tumour formation. Objectives We questioned whether there was evidence of MMR dysfunction in human SCC, thus validating the mouse models of MMR‐dependent UVB‐induced skin cancer. Methods Using tissue microarrays we examined both nuclear and cytoplasmic levels of MMR proteins MSH2, MSH6, MSH3, MLH1 and PMS2 in more than 200 cases of cutaneous SCC and basal cell carcinoma (BCC). Results We found that subsets of these 10 MMR protein measures were increased in nonmelanoma skin cancer (NMSC) compared with normal epidermal samples; this was particularly true of SCC. In fact, based on post hoc tests and MMR protein distribution patterns, BCC was distinct from SCC. With the exception of nuclear MSH2, the BCC had lower levels of identified MMR protein measures than SCC. We believe this to be important because not only is SCC more aggressive than BCC, but evidence suggests that these two NMSC subtypes arise through different molecular pathways. Conclusions In combination with previously established roles for MMR proteins in response to UVB‐induced DNA damage, our data point towards an expanded perspective of the importance of MMR proteins in the suppression of UVB‐induced tumorigenesis and, potentially, tumour behaviour.
CUTANEOUS CALCULI.*.
Authors: BRIAN WOODS, T. D. KELLAWAY
Journal: British Journal of Dermatology (1963)

Journal Article CUTANEOUS CALCULI.: Subepidermal Calcified Nodules. Get access BRIAN WOODS, BRIAN WOODS Department of Dermatology, Addenbrooke's Hospital Search for other works by this author on: Oxford Academic Google Scholar T. D. KELLAWAY T. D. KELLAWAY Department of Pathology, University of Cambridge Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 75, Issue 1, 1 January 1963, Pages 1–11, https://doi.org/10.1111/j.1365-2133.1963.tb13525.x Published: 01 January 1963
Preferential expression of a high number of ATP binding cassette transporters in both normal and leukemic CD34+CD38− cells
Authors: E P L M de Grouw, M H G P Raaijmakers, J B Boezeman, B A van der Reijden, L T F van de Locht, T J M de Witte, J H Jansen, R A P Raymakers
Journal: Leukemia (2006)
LICHEN PLANUS APPEARING ON A SCAR
Authors: M. Sydney Thomson
Journal: British Journal of Dermatology (1932)

Journal Article LICHEN PLANUS APPEARING ON A SCAR Get access M. Sydney Thomson, M.A., M.D., M.R.C.P. M. Sydney Thomson, M.A., M.D., M.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 44, Issue 1, 1 January 1932, Pages 33–34, https://doi.org/10.1111/j.1365-2133.1932.tb09537.x Published: 01 January 1932
Augmentation of J Waves and Electrical Storms in Patients with Early Repolarization
Authors: Gi-Byoung Nam, You-Ho Kim, Charles Antzelevitch
Journal: New England Journal of Medicine (2008)

To the Editor: Early repolarization, consisting of an elevation of the QRS–ST junction (J point), QRS notching or slurring (J wave), and a tall, symmetric T wave, is generally considered to be benign.1 On the basis of preclinical experimental evidence, it has been suggested that some forms of early repolarization seen in the clinic may not be benign, especially when associated with the occasional appearance of J waves or ST-segment elevation.2 Sporadic case reports and basic electrophysiological research have suggested a critical role of the J wave in the pathogenesis of idiopathic ventricular fibrillation.3,4 Clinical evidence in support of . . .
CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes
Authors: Partha Mukhopadhyay, Mohanraj Rajesh, Sándor Bátkai, Vivek Patel, Yoshihiro Kashiwaya, Lucas Liaudet, Oleg V. Evgenov, Ken Mackie, György Haskó, Pál Pacher
Journal: Cardiovascular Research (2009)

AimsHere we investigated the mechanisms by which cardiovascular CB1 cannabinoid receptors may modulate the cardiac dysfunction, oxidative stress, and interrelated cell death pathways associated with acute/chronic cardiomyopathy induced by the widely used anti-tumour compound doxorubicin (DOX).
Abstract 2133: MCPH1 interacts with the anaphase-promoting complex subunit Cdc27
Authors: Timothy D. Wiltshire, Namit Singh, Georges Mer, Fergus Couch
Journal: Cancer Research (2012)

Abstract Microcephalin (MCPH1), the first gene identified as causative for primary recessive autosomal microcephaly, is aberrantly expressed in autism-like disorders and human malignancy of breast and ovarian origin. MCPH1, the encoded protein product, has been implicated in various cellular processes including the DNA damage checkpoint, DNA repair and transcription. While our understanding of the cellular context in which MCPH1 operates continues to develop, a structural understanding of the C-terminal tandem BRCT domains of MCPH1 remains unexplored. Here, we identify Cdc27, a component of the anaphase-promoting complex (APC/C), as a novel interacting partner of MCPH1. We provide in vitro and in vivo evidence that the C-terminal tandem BRCT domains of MCPH1 (C-BRCTs) bind Cdc27 in a phosphorylation-dependent manner. To further characterize this interaction, we determined the structure of MCPH1 C-BRCTs in complex with a phosphorylated Cdc27 peptide (pCdc27) using X-ray crystallography. Based on this structure, we identified single amino acid mutations targeted at the binding interface that disrupted the MCPH1-pCdc27 interaction. Collectively, our data defines the biochemical, structural and cellular determinants of the novel interaction between MCPH1 and Cdc27 and suggests that this interaction may occur within the larger context of MCPH1-APC/C. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2133. doi:1538-7445.AM2012-2133
Inappropriate Medication Prescribing in Skilled-Nursing Facilities
Authors: Mark H. Beers, Joseph G. Ouslander, Susan F. Fingold, Hal Morgenstern, David B. Reuben, William Rogers, Mira J. Zeffren, John C. Beck
Journal: Annals of Internal Medicine (1992)

Objective: To quantify the appropriateness of medication prescriptions in nursing home residents. Design: Prospective, cohort study. Setting: Twelve nursing homes in the greater Los Angeles area. Participants: A total of 1106 nursing home residents. Main Outcome Measures: The appropriateness of medication prescriptions was evaluated using explicit criteria developed through consensus by 13 experts from the United States and Canada. These experts identified 19 drugs that should generally be avoided and 11 doses, frequencies, or durations of use of specific drugs that generally should not be exceeded. Results: Based on the consensus criteria, 40% of residents received at least one inappropriate medication order, and 10% received two or more inappropriate medication orders concurrently; 7% of all prescriptions were inappropriate. Physicians prescribed a greater number of inappropriate medications for female residents. Regression analysis, corrected for clustering effects within facilities, showed that a greater number of inappropriate medication prescriptions were ordered in larger nursing homes. Inappropriate prescriptions were not related to the proportion of Medicaid (Medical) residents or the number of physicians practicing in the homes. Conclusions: Inappropriate medication prescribing in nursing homes is common. Female residents and residents of large nursing homes are at the greatest risk for receiving an inappropriate prescription.
Sustained-Release Procainamide and Neutropenia
Authors: SCOTT ANDERSON
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 September 1984Sustained-Release Procainamide and NeutropeniaSCOTT ANDERSON, M.D., NANETTE K. WENGER, M.D.SCOTT ANDERSON, M.D.Search for more papers by this author, NANETTE K. WENGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-3-404_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Ellrodt and colleagues (1) recently reported an association between severe neutropenia and the use of sustained-release procainamide. Seven of the eight patients described presented with fever and constitutional symptoms; only one patient was asymptomatic. Although we had not seen symptomatic severe neutropenia associated with the administration of sustained-release procainamide, we chose to determine the incidence of this potentially serious complication in ambulatory patients treated at a large urban hospital.All patients who had prescriptions for sustained-release procainamide filled at the Grady Memorial Hospital outpatient pharmacy from September 1983 to February 1984 were identified by a computer search...Reference1. ELLRODTMURATARIEDINGERSTEWARTMOCHIZUKIGRAY AGMMCR. Severe neutropenia associated with sustained-release procainamide. Ann Intern Med. 1984;100:197-201. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SCOTT ANDERSON, M.D.; NANETTE K. WENGER, M.D.Affiliations: Emory University School of Medicine Cardiac Clinics Grady Memorial Hospital Atlanta, GA 30303 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProcainamide-associated blood dyscrasiasOrganotin compounds in agriculture since 1980. Part I. Fungicidal, bactericidal and herbicidal propertiesCardiac glycosides and drugs used in dysrhythmiasReply 1 September 1984Volume 101, Issue 3Page: 404-404KeywordsComputersFeversNeutropeniaOutpatient clinics ePublished: 1 December 2008 Issue Published: 1 September 1984 PDF downloadLoading ...
Dexamethasone and Postoperative Bleeding After Tonsillectomy in Children
Authors: Joel B. Gunter
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lipoma Arborescens Successfully Treated With 90Y Synovectomy
Authors: Jim O’Doherty, Ralf Clauss, James Scuffham, Aman Khan
Journal: Clinical Nuclear Medicine (2013)

Lipoma arborescens (LA) in the knee is a benign intra-articular lipomatous proliferation of the synovial membrane, and data on treatment of LA by radionuclide therapy is sparse. We present a rare case of bilateral LA in the knees successfully treated with injection of Y-citrate colloid. We assessed the biodistribution of the radiopharmaceutical through the use of SPECT/CT imaging. Our images show slight redistribution of the radiocolloid in the knee joint, whereas most of the radioactivity remains localized around the LA. MRI scans confirmed the efficacy of this treatment, with a significant reduction in LA volume after 6 months.
Putting GPs in charge of NHS budget is an "extraordinary gamble"
Authors: M. Limb
Journal: BMJ (2010)

GPs are about to be given “too much” control “too fast” over most NHS expenditure, says a health economist.

Zack Cooper, a health economist at the London School of Economics and Political Science (LSE), warned that the coalition government’s commissioning reforms were risky and likely to increased costs.

He said, “When funds are tight, this big a shift of purchasing power to an untested system is an extraordinary gamble. We know that large scale shake ups typically cost substantial amounts of money.”

The white paper, Equity and Excellence: Liberating the NHS , which was published in July 2010, proposes to hand …
Controlling Tuberculosis in India
Authors: G.R. Khatri, Thomas R. Frieden
Journal: New England Journal of Medicine (2002)

Tuberculosis kills nearly 500,000 people in India each year. Until recently, less than half of patients with tuberculosis received an accurate diagnosis, and less than half of those received effective treatment.We analyzed the effects of new policies introduced in 1993 that have resulted in increased resources, improved laboratory-based diagnosis, direct observation of treatment, and the use of standardized antituberculosis regimens and reporting methods.By September 2001, more than 200,000 health workers had been trained, and 436 million people (more than 40 percent of the entire population) had access to services. About 3.4 million patients had been evaluated for tuberculosis, and nearly 800,000 had received treatment, with a success rate greater than 80 percent. More than half of all those treated in the past 8 years were treated in the past 12 months.India's tuberculosis-control program has been successful in improving access to care, the quality of diagnosis, and the likelihood of successful treatment. We estimate that the improved program has prevented 200,000 deaths, with indirect savings of more than $400 million--more than eight times the cost of implementation. It will be a substantial challenge to sustain and expand the program, given the country's level of economic development, limited primary health care system, and large and mostly unregulated private health care system, as well as the dual threats of the human immunodeficiency virus and multidrug-resistant tuberculosis.
YOUNG OBESE MEN ARE CHARACTERIZED BY MULTIPLE CORONARY RISK FACTORS, A LARGER INFARCT SIZE, AND IMPAIRED MYOCARDIAL REPERFUSION IN PATIENTS WITH ANTERIOR ACUTE MYOCARDIAL INFARCTION
Authors: Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi, Kengo Tsukahara, Noriaki Iwahashi, Nobuhiko Maejima, Yoshio Tahara, Satoshi Umemura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2013)
Using pentobarbital in executions puts the inmates at undue risk of suffering, report says
Authors: C. Dyer
Journal: BMJ (2011)

Procedures for putting animals to death in the US state of Texas are much stricter than those for executing humans, says a new report from the American Civil Liberties Union (ACLU) and Northwestern University School of Law.

Texas has switched to using pentobarbital instead of thiopental sodium as part of its lethal injection protocol, after supplies of thiopental ran out when the sole US manufacturer pulled out of the market.

But the switch has been done without any proper scientific analysis and despite concerns raised by anaesthesiologists, says the report. Lethal injection procedures on death row are in the hands of correction …
THE RELATION OF THE HYPOTHALAMUS TO THE PITUITARY GLAND
Authors: E. C. Dodds, R. L. Noble
Journal: BMJ (1936)

The apparent relation of the hypothalamus to the posterior lobe of the pituitary gland was first suggested from the observations that the condition of diabetes insipidus could be successfully treated by injections of pituitary extract.Clinically, various disturbances in fat and carbohydrate metabolism, body-heat regulation, and dysfunction of the sex glands, as well as diabetes insipidus, have been described as originating from hypothalamic damage.Considerable confusion, however, has been caused in trying to assess whether such changes are due primarily to brain damage or to associated lesions of the pituitary gland, since the pathological process is seldom one confined to a localized area.Experimental conditions have made it possible to produce controlled areas of damage and reproduce most of the changes found clinically. Anatomical and Functional RelationsThe intimate connexion of the posterior lobe of the pituitary gland with the tuber cinereum by the infundibulum and pituitary stalk is well known.The tuber cinereum, forming part of the floor of the third ventricle, extends from the optic commissure in front to the mam- millary bodies behind.Laterally it is continuous with the anterior perforated substance, the sublenticular region, and the ventral surface of the anterior part of the thalamus.Cloakel describes the following groups of large cells found in this region.
Steatorrhea Induced by Para-aminosalicylic Acid
Authors: ROBERT A. LEVINE
Journal: Annals of Internal Medicine (1968)

The effects of abnormally high (12 g) and normal (6 g) daily doses of para-aminosalicylic acid (PAS) recrystallized with ascorbic acid (PAS-C) on absorptive function was investigated in seven healthy volunteer subjects. Oral administration of 12 g/day of PAS-C for 4 weeks induced moderate steatorrhea, without diarrhea, in all seven subjects. Six grams per day of PAS-C failed to produqce malabsorption of fats. The drug exhibited no direct toxic effect on intestinal epithelium, as determined by light microscopy. Jejunal mucosal biopsies performed before, during, and after PAS-C administration, at either 6- or 12-g daily doses, showed no alterations in the normal histology. The degree of steatorrhea did not appear to account entirely for the diminished cholesterol concentrations observed during PAS-C therapy. The data indicate that PAS-C, at the 12-g daily dosage, represents another model for investigation of reversible drug-induced malabsorption in man. In contrast, PAS-C in the doses generally recommended did not induce changes in absorptive function.
Tc-99m HMPAO WBC Imaging to Detect Carditis and to Evaluate the Results of High-dose Gamma Globulin Treatment in Kawasaki Disease
Authors: CHIA-HUNG KAO, KAI-SHENG HSIEH, YEN-LIANG WANG, CHEIN-WANG CHEN, SHU-QUINN LIAO, SHYH-JEN WANG, SHIN-HWA YEH
Journal: Clinical Nuclear Medicine (1992)

Eighteen patients with Kawasaki disease and suspected carditis (11 boys, 7 girls, mean age 18 months) in acute stages underwent Tc-99m HMPAO WBC imaging of the heart. Signs and symptoms subsided after conventional aspirin therapy and the intravenous injection of high-dose (400 mg/kg per day for 5 days) γ-globulin treatments. Tc-99m HMPAO WBC imaging of the heart was arranged a second time to evaluate the effects of the treatments for carditis. The results showed that a significant difference existed in the severity of carditis before and after the treatments (P < 0.001, by signed rank test), 39% (7/18) with significant improvement in severity of carditis, 50% (9/18) without definite change. However, 11% (2/18) became more severely ill after the treatments. Tc-99m HMPAO WBC imaging may be useful in detecting carditis in Kawasaki disease and in evaluating the effects of aspirin plus the newly recommended γ-globulin for the treatment of carditis in Kawasaki disease.
Possible Discrimination in Recruitment of Psychiatry Residents?
Authors: Richard Balon, Rizwan Mufti, Mark Williams, Michelle Riba
Journal: American Journal of Psychiatry (1997)

OBJECTIVE: The authors sought to determine whether there is a selection bias against international medical graduate applicants for U.S. residency training positions in psychiatry. METHOD: Identical requests for a program application were sent by two resident applicants—one international medical graduate and one graduate of a U.S. medical school—to 193 residency training programs, and the rate and character of responses were compared. RESULTS: The response rate to requests for an application form was significantly higher for the U.S. medical school graduate (159 responses) than the international medical graduate (87 responses). The quality of responses was also different in some cases. CONCLUSIONS: Some residency programs in psychiatry are attempting to limit the influx of international medical graduate applicants at the very first level: the request for an application form. The reasons for this practice are not known, but discrimination could be a possible explanation. (Am J Psychiatry 1997; 154:1608–1609)
Oxygen Transport: Principles and Practice
Authors: A Henderson
Journal: BMJ (1994)

J D Edwards, W C Shoemaker, J-L Vincent; W B Saunders, pounds sterling30, pp 367; ISBN 0-7020-1576-8

During the past decade there has been such an enormous outpouring of publications relating to the cellular biology of oxygen that few, except for enthusiasts, can have kept abreast of the topic.The publication of a concise book such as Oxygen Transport, which extensively reviews and summarises current knowledge, is therefore timely.

The editors have retained balance and perspective by employing a multinational team of authors.The book is divided into two sections. Section one deals with the underlying applied physiology …
187 Efficacy and safety of 22 weeks of maintenance therapy with peginterferon alfa-2A (40KD) (PEGASYS™) alone versus peginterferon alfa-2A (40KD) plus ribavirin(COPEGUS™) in naive patients with chronic hepatitis C and genotype 1 who responded to a 24-week course of peginterferon alfa-2A (40KD) plus ribavirin: an open, multicenter, randomized trial
Authors: J BRONOWICKI, D OUZAN, A TZANCK, T ASSELAH, H DESMORAT, J ZARSKI, J FOUCHER, M BOURLIERE, C RENOU, A TRAN
Journal: Hepatology (2003)
Experts question how India will meet promises on public health after cut in budget for 2015-16
Authors: G. Mudur
Journal: BMJ (2015)

A proposed 16% cut in funding for the Indian health ministry for the coming fiscal year has triggered concerns over how the government will keep the pledges it made last year to provide free drugs and diagnostic tests and universal healthcare coverage.

The Indian government’s budget for the year beginning 1 April 2015, presented by the finance minister Arun Jaitley on 28 February, has allocated Rs297bn (£3bn; €4bn; $4.5bn) to the health and family welfare ministry—less than the previous fiscal year’s budget of Rs352bn.

The central government said that a modified financial plan aimed at increasing devolution of tax revenues would provide states across the country with extra funds for use in health, among other sectors. But public health experts have said that the budget …
Multiple-crystal acute polyarthritis
Authors: L. A. Rubin, K. P. H. Pritzker, P.-T. Cheng, A. G. Fam
Journal: Annals of the Rheumatic Diseases (1983)

A patient with acute polyarthritis due to crystal-positive simultaneous gout and pseudogout affecting different joints is described. The case emphasises the importance of aspirating more than one involved joint and carefully searching for crystals in patients with acute arthritis involving 2 or more joints, particular those in whom the diagnosis of multiple crystalline joint disease is considered.