tbuckley/cabot-search huggingface dataset:
Effects of Intracoronary Streptokinase and Intracoronary Nitroglycerin Infusion on Coronary Angiographic Patterns and Mortality in Patients with Acute Myocardial Infarction
Authors: K. Peter Rentrop, Frederick Feit, Heinrich Blanke, Peter Stecy, Richard Schneider, Mariano Rey, Steven Horowitz, Martin Goldman, Karl Karsch, Henry Meilman, Marc Cohen, Stephen Siegel, Joseph Sanger, James Slater, Richard Gorlin, Arthur Fox, Richard Fagerstrom, W. Ford Calhoun
Journal: New England Journal of Medicine (1984)

We randomly assigned patients with a clinical diagnosis of acute myocardial infarction to one of four treatment groups: intracoronary streptokinase, intracoronary nitroglycerin, intracoronary streptokinase and intracoronary nitroglycerin, or conventional therapy without initial angiography. Of 124 patients 122 sustained acute myocardial infarction. Initial angiography revealed total occlusion of the coronary artery responsible for infarction in 67 per cent (61 of 91). Acute recanalization occurred in 74 per cent (32 of 43) of patients receiving streptokinase but in only 6 per cent (1 of 18) of patients treated with nitroglycerin alone (P<0.01). At angiography of all four groups on Day 10 to 14 the vessel responsible for acute myocardial infarction was patent in 77 per cent (71 of 92) of patients; there was no difference among groups, indicating gradual, endogenous thrombolysis in patients not treated with streptokinase. Patients with subtotal obstruction initially had significant improvement in left ventricular function, significantly lower peak creatine kinase levels, and a trend toward lower mortality than patients with total occlusion initially. Mortality at six months in patients receiving streptokinase (21 per cent, 13 of 62) did not differ significantly from that in patients not treated with streptokinase (10 per cent, 6 of 61). Additional studies will be necessary to assess treatment effects in the angiographic subsets identified by this trial. (N Engl J Med 1984; 311:1457–63.)
Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo
Authors: Hongki Yoo, Jin Won Kim, Milen Shishkov, Eman Namati, Theodore Morse, Roman Shubochkin, Jason R McCarthy, Vasilis Ntziachristos, Brett E Bouma, Farouc A Jaffer, Guillermo J Tearney
Journal: Nature Medicine (2011)
INTRALIGAMENTOUS FIBROMYOMA COMPLICATING PREGNANCY AT FULL TERM; HYSTEROMYOMECTOMY; RECOVERY.
Authors: RICHARD DOUGLAS
Journal: JAMA (1896)

As the records do not abound with cases of complete hysterectomy for fibroid complicating pregnancy, I presume a detailed report of the following case will bear some interest: Mrs. N., 33 years of age, a multipara; her youngest child was born five years ago. All labors normal with uncomplicated convalescence. During the year 1894 there had been some menstrual disorder, irregularity and at times profuse flow. In May, 1895, she consulted Dr. J. W. McCall for her uterine trouble; the result of the examination I report in his words. "I made a digital and specular examination, was unable to find the os uteri. The right vaginal vault and iliac region were filled with a hard tumor." The case passed from under Dr. McCall's observation and was not seen by him again until March 8, 1896, when he was called in consultation with Dr. Howard. The patient had then been in
An Inquiry Concerning the best Climate and Waters for Bright's Disease.
Authors: E. L. B. Godfrey
Journal: JAMA (1896)

Camden, N. J., Jan. 26, 1896. <h3>To the Editor:</h3> —Can you advise me whatlocation and climate, in this country, offer, in your judgment, the most hope for a person afflicted with incipient Bright's disease to visit? Any answer, on inquiry throughThe Journal, you may be good enough to make will be appreciated by Yours truly,
Gas Masks for Persons With Tracheostomy
Authors: D. Soroker, S. Lurie, T. Ezri
Journal: JAMA (1991)

<h3>To the Editor.—</h3> Gas masks are a safe and well-known protection against nerve gases such as sarin, soman, or tabun. The mask prevents nerve gas absorption via the pulmonary and mucous membranes. However, in patients with permanent or temporary tracheostomy and spontaneous breathing, additional measures are required to provide protection. Withstanding the threat of Iraqi nerve gases attack, we faced an immediate necessity for protecting the airways of such patients. We have developed a simple device that fulfills the essential requirements. The device consists of a swivel connector and extension flex tubes. The filter of the gas mask is connected to the distal edge of the extension flex tube, and the filter opening is sealed. The gas mask is placed on the patient for oral, nasal, and conjuctival protection, and the extension flex tube with the gas filter is connected to the system for pulmonary tree protection (Figure). We believe
Functional and Clinical Characterization of the Putative Tumor Suppressor WWOX in Non-small Cell Lung Cancer
Authors: Silvan Becker, Boyka Markova, Rainer Wiewrodt, Sandra Hoffarth, Patricia S. Hähnel, Sina Pleiner, Lars Hennig Schmidt, Frank Breitenbuecher, Martin Schuler
Journal: Journal of Thoracic Oncology (2011)
Medical Neurobiology: Neuroanatomical and Neurophysiological Principles Basic to Clinical Neuroscience
Authors: Simon Horenstein
Journal: JAMA (1982)

Advances in all aspects of neuroscience have influenced and will continue to influence the practice of medicine. The number of neurologists will probably remain small relative to the frequency and seriousness with which the nervous system is affected by disease. The neurological education of the medical student may be his only formal exposure ever to the subject. It is with these thoughts in mind that one reviews<i>Medical Neurobiology</i>. The current (third) edition is organized around a dozen chapters proceeding from the neuron through major treatments of structure, functional systems, and behavior, culminating in a discussion of the application of the principles of neurobiology to diagnosis. An appendix includes an anatomic atlas, a discussion of mathematical concepts, and a précis of anatomic and physiological techniques. The early chapters treating neurons, synapses, receptors, peripheral nerves, and the spinal cord are lucid and well illustrated, including sharply defined and beautifully reproduced electron
Lingering Questions on Choledochal Cysts
Authors: David Linehan, Eva Galka
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Effects of p-chlorophenoxyisobutyrate on myocardial free fatty acid extraction, ventricular blood flow, and epicardial ST-segment elevation during coronary occlusion in dogs.
Authors: O D Mjos, N E Miller, R A Riemersma, M F Oliver
Journal: Circulation (1976)

The effect of p-chlorophenoxyisobutyrate (CPIB) on ST-segment elevation in epicardial electrocardiographic recordings was studied during coronary artery occlusion in dogs. Occlusion alone raised the sum of ST-segment elevations (sigmaST) to 26 +/- 6 mV (mean +/- SEM). Intravenous (i.v.) administration of CPIB 30 min before re-occlusion reduced sigmaST to 14 +/- 3 mV (P less than 0.03). A continuous i.v. infusion of isoproterenol increased sigmaST to 74 +/- 11 mV. Pretreatment with CPIB reduced sigmaST during isoproterenol infusion to 40 +/- 7 mV (P less than 0.005). CPIB had no effect on mean aortic blood pressure, heart rate, or regional myocardial blood flow, as measured by radioactive microspheres. Arterial free fatty acid (FFA) concentrations were reduced by CPIB from 466 +/- 41 to 221 +/- 44 muEq/L (P less than 0.001) in the basal state, and from 1966 +/- 183 to 1429 +/- 209 muEq/L (P less than 0.001) during isoproterenol infusion. The reduction in arterial FFA concentration was associated with a proportionate decrease in the myocardial extraction of FFA. Similar changes were observed when CPIB was administered during an occlusion which had been established 10 min earlier. These observations support other evidence that the severity of acute myocardial ischemic injury in dogs is positively correlated with the myocardial extraction of FFA, and that the severity of the ischemic injury can be reduced by effective antilipolytic therapy.
Improved Detection of the Sickle Mutation by DNA Analysis
Authors: Stuart H. Orkin, Peter F. R. Little, Haig H. Kazazian, Corinne D. Boehm
Journal: New England Journal of Medicine (1982)

DETECTION of sickle hemoglobin in the human fetus was first accomplished nearly 10 years ago.1 , 2 This marked the beginning of a technology for prenatal diagnosis of the hemoglobinopathies. When methods for acquisition of fetal blood and for analysis of globin-chain synthesis were developed, the prenatal diagnosis of sickle-cell anemia and the thalassemia syndromes became a practical reality.3 , 4 Nearly 2000 fetuses at risk for these disorders have now been studied worldwide.5 However, a fetal loss of about 5 per cent due to these invasive procedures has provided the impetus for the development of diagnostic approaches that use fetal DNA rather than . . .
Dynamics of hepatic connective tissue matrix constituents during murine schistosoma mansoni infection
Authors: Safaa El Meneza, Richard G. Olds, Thomas F. Kresina, Adel A. F. Mahmoud
Journal: Hepatology (1989)

Hepatic fibrosis is the major clinical sequela of infection with the helminth Schistosoma mansoni. However, little is known regarding its dynamics and regulation in schistosomiasis. The present study presents the dynamics of deposition and resorption of two major extracellular matrix components of fibrosis, glycosaminoglycans and collagens, during the course of experimental S. mansoni infection. Early in infection (6 weeks), glycosaminoglycan biosynthesis was markedly elevated, as was collagen biosynthesis. This led to significant accumulations of these two molecules at a glycosaminoglycan/collagen ratio similar to that observed in livers of uninfected mice (uronic acid/hydroxyproline ratio of 1.10 at 6 weeks compared to normal value of 1.25). During maximal hepatic fibrosis (12 to 18 weeks), both collagen and glycosaminoglycan biosynthesis continued to increase but the extracellular matrix shifted to a lower glycosaminoglycan/collagen ratio of 0.42, suggesting enhanced glycosaminoglycan breakdown. In addition, during this acute stage of infection, Type I collagen was the predominant isotype synthesized, whereas total collagenolytic activity degrading Type I collagen was maximal. During chronic infection, a decrease in the content of both hepatic glycosaminoglycans and collagens were noted, with a glycosaminoglycan/collagen ratio of 0.63. Decreased glycosaminoglycan content paralleled diminished biosynthetic rates. On the other hand, an over 50% reduction in collagen content (from 18 to 24 weeks) appeared not to result from diminished biosynthesis but from a switch in the predominant collagen isotype synthesized (from Type I to Type III), matched by an enhanced constitutive collagenolytic activity directed toward this type of collagen.(ABSTRACT TRUNCATED AT 250 WORDS)
Calcium Oscillations in Anterior Pituitary Cells
Authors: STANKO S. STOJILKOVIĆ, KEVIN J. CATT
Journal: Endocrine Reviews (1992)

OVER the last two decades it has become evident that intracellular Ca2+ signals are critically important for the control of cellular activities including excitability, exocytosis, and contraction, as well as cell growth, differentiation, and division. Elevations of [Ca2+]i occur spontaneously or in response to agonist stimulation and are commonly expressed as prominent Ca2+ oscillations in single cell studies. Such oscillations are dependent on the entry of Ca2+ and/or its release from intracellular stores. In many cell types, both mechanisms are involved in the generation of Ca2+ oscillations. The cellular pathways involved in the regulation of Ca2+ entry include VSCC, receptor- and second messenger-operated Ca2+ channels, and mechanically operated Ca2+ channels. Ca2+ discharge from intracellular Ca2+ pools also occurs through calcium channels; one of these is the inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]-sensitive- and another is the ryanodine-sensitive Ca2+ release channel (1). In pituitary cells, spontaneous calcium oscillations are usually associated with Ca2+ entry through VSCC, and are typical of excitable endocrine cells. In addition to VSCC, sodium, potassium, calcium-activated potassium, and chloride channels are present in pituitary cells. The sum of the various currents flowing at any time point determines the pituitary cell membrane potential. In these cells, action potentials (APs) are triggered by a slow depolarization that reaches the threshold for opening VSCC. The inward calcium current then further depolarizes the plasma membrane, leading to Ca2+ influx which in turn is terminated indirectly by rapid activation of transient voltage-dependent K+ channels, and/or activation of Ca2+-sensitive K+ channels, which repolarize the membrane (2–5). This mechanism forms the basis of the plasma-membrane oscillator (6). Several agonists operate through facilitatory or inhibitory modulation of plasma membrane oscillatory activity (7, 8).
Comparison of various treatments for irritable bowel syndrome
Authors: A A Schiff
Journal: BMJ (1981)

coccoid rods used by Mayberry.There are indications from our results that Eubacterium and Bifidobacterium are antigenically related.We have also noted a close correlation between IgG antibodies to Bifidobacterium bifidum and the duration of Crohn's disease (p =0 0006).It would therefore be of interest to know if the patients in the study by Dr Mayberry and colleagues giving poor correlations with agglutinations were recently diagnosed cases of Crohn's disease.In our study ulcerative colitis patients gave a slightly raised level of antibodies to Bifidobacterium bifidum but this was not significantly different from that in normal subjects.Finally, we should state that Wensinckt found no difference between the numbers of Bifidobacterium in the faecal flora of Crohn's patients and of normal subjects.
Local intralesional therapy with rhGM-CSF for a large genital ulcer in Behçet's disease
Authors: N. Alli, G. Karakayali, İ Kahraman, F. Artüz
Journal: British Journal of Dermatology (1997)

Journal Article Local intralesional therapy with rhGM‐CSF for a large genital ulcer in Behçet's disease Get access N. Alli, N. Alli Numune Hospital Department of Dermatology, Ankara, Turkey Search for other works by this author on: Oxford Academic Google Scholar G. Karakayali, G. Karakayali Numune Hospital Department of Dermatology, Ankara, Turkey Search for other works by this author on: Oxford Academic Google Scholar İ Kahraman, İ Kahraman Numune Hospital Department of Dermatology, Ankara, Turkey Search for other works by this author on: Oxford Academic Google Scholar F. Artüz F. Artüz Numune Hospital Department of Dermatology, Ankara, Turkey Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 4, 1 April 1997, Pages 639–640, https://doi.org/10.1111/j.1365-2133.1997.tb02170.x Published: 01 April 1997
Activation and partial characterization of a human reticulocyte heme‐dependent elF‐Z α kinase
Authors: R. S. Franco, J. W. Hogg, O. J. Martelo
Journal: American Journal of Hematology (1981)

Abstract An inhibitor of globin translation initiation that is activated under heme‐deficient conditions and whose activity is associated with phosphorylation of the 38,000 dalton (α) subunit of the initiation factor eIF‐2 has been previously described in rabbit reticulocytes. We describe here an analogous enzyme in human reticulocytes. The human enzyme can be activated in intact reticulocytes under conditions of heme synthesis inhibition or by incubation of lysates in the absence of hemin. Addition of hemin to lysates prevents activation of the eIF‐2 a kinase. The partially purified kinase is associated with inhibition of globin synthesis in a rabbit cell‐free system and phosphorylates the small subunit of highly purified rabbit eIF‐2. We conclude that human reticulocytes contain a protein kinase that is analogous to the rabbit HCR and that may play a role in clinical heme deficiency states.
Alzheimer??s Disease in Down??s Syndrome with SPECT
Authors: ALEXANDER D. RAE-GRANT, PETER J. BARBOUR, PAUL SIROTTA, PAUL GROSS
Journal: Clinical Nuclear Medicine (1991)

Alzheimer's disease often occurs in patients with Down's syndrome. SPECT scanning with I-123 IMP and Tc-99m HMPAO identifies decreased cerebral perfusion and metabolism in these patients at lower cost. In this case, SPECT scanning revealed changes in Alzheimer's disease in a Down's syndrome patient.
High-dose cytarabine-containing chemotherapy with or without granulocyte colony-stimulating factor for children with acute leukemia
Authors: Shu-Huey Chen, Der-Cherng Liang, Hsi-Che Liu
Journal: American Journal of Hematology (1998)

We sought to determine the role of granulocyte colony-stimulating factor (G-CSF) as an adjunct therapy in high-dose cytarabine-containing chemotherapy (HD C/T) for children with acute leukemia. Seventeen patients, aged 9 months to 18 years old, 8 ALL and 9 AML, were treated with cytarabine (Ara-C) 1 g/m2 q12h for 8 doses with mitoxantrone, idarubicin, VP-16, or asparaginase. A total of 71 courses of HD C/T was given. G-CSF was not used in 14 courses (Group A). Prophylactic G-CSF was given in 57 courses (Group B) as 200 μg/m2/d SC started one day after the completion of HD C/T and continued until the neutrophil recovery was maintained. The incidences of sepsis per course in Group A and Group B were 35.7% (5/14) and 40.4% (23/57), respectively. While 2 patients in Group A died of sepsis or pneumonia, none in Group B died. The mortality and delay in chemotherapy were fewer in Group B (P = 0.037 and 0.0006, respectively, Fisher exact test). There was a shorter average number of days of neutrophil <500/cumm, antibiotic usage, fever, and hospital stay in Group B (11, 8, 5, 17 days in Group B vs. 21, 17, 10, 37 days in Group A; P = 0.0001, log-rank test; 0.0006, 0.0023, 0.0001, Wilcoxon rank sum test, respectively). The incidence of neutropenic fever was lower in Group B, but the difference did not reach statistical significance (P = 0.06, Fisher exact test). We conclude that G-CSF as an adjunct therapy in HD C/T is effective in reducing mortality, days of neutropenia, antibiotic usage, fever, hospital stay, and frequency of delay in chemotherapy. The efficacy of this treatment approach requires further testing in a randomized, controlled trial. Am. J. Hematol. 58:20–23, 1998. © 1998 Wiley-Liss, Inc.
Clinics in gastroenterology: Infections of the GI tract
Authors: H. Smith
Journal: Gut (1980)

chapters on motility.Diet, and psycho- logical aspects, are not considered, and the liver is allotted little more than two chapters.The book has to compete with review articles which appear regularly in the journals.The editors have sought to provide a balance of topics within gastro- enterology, and, as a balanced and thoughtful text, it is the best available.It is a book that will be read with interest by gastroenterologists,
Acid clearance and oesophageal sensitivity in patients with progressive systemic sclerosis.
Authors: G Basilisco, R Barbera, M Molgora, M Vanoli, P Bianchi
Journal: Gut (1993)

This study examined the hypothesis that impaired oesophageal peristalsis was associated with delayed oesophageal clearance of acid in patients with progressive systemic sclerosis (PSS), some of whom are thought to have impaired oesophageal sensitivity to acid. Sixteen patients with PSS had: (a) oesophageal manometry and endoscopy; (b) acid perfusion of the oesophagus with simultaneous measurement of intraoesophageal pH during perfusion and for the next 10 minutes; (c) 22 hour monitoring of intraoesophageal pH; and (d) an evaluation of reflux symptoms during and after perfusion and during overnight pH monitoring. By oesophageal manometry, eight patients had normal peristalsis and eight patients had impaired peristalsis. Oesophageal endoscopy was unremarkable in patients with normal peristalsis, whereas all patients with impaired peristalsis had oesophagitis. The time needed to clear the oesophagus of perfused acid was shorter (p < 0.01) in patients with normal peristalsis and acid clearance time was significantly correlated (p < 0.01) with acid exposure time during overnight pH monitoring. During and after oesophageal perfusion, the nature, duration, and severity of symptoms did not differ between the groups, but overnight symptoms lasted longer (p < 0.05) in patients with impaired peristalsis. It is concluded that in PSS: (1) Impaired oesophageal motility delayed the clearance of acid and increased the exposure time to acid. (2) Acid clearance time is a useful parameter of impaired oesophageal motor function. The assessment of acid clearance time can be used as an alternative to overnight pH monitoring, to assess the impairment of oesophageal acid clearance. (3) Oesophageal sensitivity to acid was preserved in patients with impaired peristalsis and oesophagitis. (4) Reflux symptoms lasted longer in patients with prolonged oesophageal acid exposure but were still reported for a small fraction of the total acid exposure time. Thus, reflux symptoms reflect poorly prolonged exposure of the oesophagus to acid and are not a reliable guide to acid injury of the oesophagus in PSS.
Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes
Authors: Nyasha Chambwe, Matthias Kormaksson, Huimin Geng, Subhajyoti De, Franziska Michor, Nathalie A. Johnson, Ryan D. Morin, David W. Scott, Lucy A. Godley, Randy D. Gascoyne, Ari Melnick, Fabien Campagne, Rita Shaknovich
Journal: Blood (2014)
Ultrasound and Physical Examinations for Obese Patients—Reply
Authors: Ann Willman Silk
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal