tbuckley/cabot-search huggingface dataset:
Recent Studies on the Mechanism of Action of Testosterone
Authors: Daniel Deykin, Christine Balko, Jean D. Wilson
Journal: New England Journal of Medicine (1972)

IN considering how a steroid such as testosterone (17β-hydroxyandrost-4-en-3-one) exerts its diverse effects, a variety of questions can be posed. The first relates to the molecular mechanisms by which the hormone promotes differentiation, growth or function of specific tissues. It is disappointing that nearly a decade after the demonstration of the intranuclear binding of the hormone within target cells and the elucidation of the thesis that testosterone, like other steroid hormones, acts in the nucleus to promote transcription or effective translation of stored genetic information (or both), it is unclear how such binding regulates the genetic machinery. A second problem . . .
Left Ventricular Performance before and after Removal of the Noncontractile Area of the Left Ventricle and Revascularization of the Myocardium
Authors: SOICHIRO KITAMURA, MAX ECHEVARRIA, JEROME HAROLD KAY, BERNARD G. KROHN, JOHN V. REDINGTON, ADOLFO MENDEZ, PABLO ZUBIATE, EDWARD F. DUNNE
Journal: Circulation (1972)

The left ventricular volume and the internal surface areas of noncontractile regions were measured by cineangiocardiography at 60 frames/sec in nine patients with a chronic localized noncontractile area of the left ventricle. Arteriosclerotic heart disease was proven in eight patients by means of coronary arteriography. Left ventricular end-diastolic pressure, stroke volume, ejection fraction, mean circumferential shortening, and cardiac output were also measured before and after removal of the noncontractile area and revascularization of the myocardium. The noncontractile areas, measured at end-diastole, ranged from 12 to 40% of the internal surface area of the left ventricle. Generally, impairment of the left ventricular function depended on the size of the noncontractile areas. The end-diastolic volume was approximately 150 ml/m 2 when the size of noncontractile areas exceeded 20-25% of the left ventricular surface area (r = +0.72; P &lt; 0.05). The ejection fraction decreased as the size of the noncontractile areas increased (r = –0.81; P &lt; 0.01). Following surgery, the left ventricular function, as well as the clinical condition, improved significantly, although the cardiac performance remained in the abnormal range in most patients. The ejection fraction increased ( P &lt; 0.05), and the percent circumferential shortening also improved ( P &lt; 0.05). Removal of the noncontractile area of the left ventricle and revascularization of the myocardium improved the cardiac performance and increased the sense of well being in these patients.
Diuretic Action of Ethacrynic Acid in Congestive Heart Failure
Authors: D. Daley, B. Evans
Journal: BMJ (1963)

human blood groups, we would certainly have suggested that the small differences of blood-group frequency among different sorts of smoker and between smokers and non- smokers were most probably the effect of sampling varia- tion.As it is, our results are not in conflict with those of Cohen and Thomas (1962), and it is still possible, therefore, that an association between blood group B and smoking may exist generally.Most encouraging is the fact that this association may be of the relatively simple form of a contrast between those who have never smoked and those who have, the former showing an excess of group B. Such an excess is present in both negro and white males in Cohen and Thomas's series and in the present series.It is to be hoped that further data will be accumulated by other workers; the fact that the apparent association is with the relatively rare blood group B means that large numbers will be required before chance can be ruled out as its source.The importance of showing the existence of any differences in blood-group frequency in relation to smoking, as was pointed out in the British Medical Journal (1962), is clear.Any such differences could reflect a genetic element in the adoption of different smoking habits or heterogeneity of the population in this respect for other reasons.In either case light might be thrown on the relation of smoking both to lung cancer and to chronic bronchitis by a search for corresponding variations in the apparent risks of these conditions.To date no particular blood group has been found to be associated with the development of lung cancer, and our findings (Higgins et al., 1963) suggest that in miners, at least, neither blood group nor secretor status is related to the respiratory symptoms on which a diagnosis of chronic bronchitis is usually based, but further observations are desirable.Summary ABO and rhesus blood groups, secretor status, and smoking habits have been determined in 85% of a random sample of miners and ex-miners aged 35-64 from the Rhondda Fach.Neither blood group nor secretor status was significantly related to smoking habits.Our findings and those of Cohen and Thomas in respect of the ABO system and smoking do not, however, differ significantly, and further studies are needed to increase the accuracy of the pooled estimate, which at present suggests that the small number of men who have never smoked is half as large again in group B as in other groups.
Communicating With Spanish-Speaking Patients
Authors: Yvon F. Bryan
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fire fighting and coronary heart disease.
Authors: E Dibbs, None Thomas HE JrU, S T Weiss, D Sparrow
Journal: Circulation (1982)

Some studies suggest that fire fighters are at a higher risk of developing coronary heart disease than are males in the general population. We followed 1646 men for 10 years to determine the incidence of coronary heart disease. Subjects were participants of the Normative Aging Study, a longitudinal study of aging. Comparison of fire fighters (n = 171) and non-fire fighters (n = 1475) showed no significant difference in the incidence rates of coronary heart disease. Comparison of the groups regarding baseline risk factors revealed no material difference. These data suggest that fire fighters do not have an excess risk of coronary heart disease.
Hospital Admissions and Fine Particulate Air Pollution
Authors: Francesca Dominici, Roger D. Peng, Michelle L. Bell, Luu Pham, Aidan McDermott, Scott L. Zeger, Jonathan M. Samet
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CUTANEOUS XANTHOMA AND "XANTHOMATOSIS" OF OTHER PARTS OF THE BODY—PITUITARY XANTHOMATOSIS— "XANTHOMAYELOMATA" OF TENDON-SHEATHS, ETC.—AND THE "CHOLESTERIN DIATHESIS."
Authors: F. PARKES WEBER
Journal: British Journal of Dermatology (1924)

Journal Article CUTANEOUS XANTHOMA AND “XANTHOMATOSIS” OF OTHER PARTS OF THE BODY—PITUITARY XANTHOMATOSIS—“XANTHOMAYELOMATA” OF TENDON‐SHEATHS, ETC.—AND THE “CHOLESTERIN DIATHESIS.” Get access F. PARKES WEBER, M.A., M.D., F.R.C.P. F. PARKES WEBER, M.A., M.D., F.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 36, Issue 8-9, 1 August 1924, Pages 335–370, https://doi.org/10.1111/j.1365-2133.1924.tb09207.x Published: 01 August 1924
Antigenic and allergenic differences between 16 different cultivars of <i>Olea europaea</i>
Authors: J. Conde Hernández, P. Conde Hernández, M. T. Gónzalez Quevedo Tejerína, M. A. Conde Alcañiz, E. M. Conde Alcañiz, P. Crespo Moreira, M. Cabanillas Platero
Journal: Allergy (2002)
Rearrangement and expression of T cell antigen receptor and gamma genes during thymic development.
Authors: R Haars, M Kronenberg, W M Gallatin, I L Weissman, F L Owen, L Hood
Journal: The Journal of Experimental Medicine (1986)

Rearrangement and expression of the T cell antigen receptor and the gamma genes during T cell ontogeny is a regulated process; the gamma genes are rearranged and expressed first, followed by the beta and then the alpha genes. Expression of both functional alpha and beta gene RNA first occurs at day 17 of gestation, along with the expression of T3 delta chain RNA. T cell antigen receptor gene rearrangements occur primarily or exclusively in the thymus, although some gamma gene rearrangements occur outside the thymus in fetal liver cells that may be committed T cell progenitors. There is no gross difference in the extent of beta and gamma gene rearrangements in the adult thymocyte subpopulations that were analyzed, despite the fact that some of these populations cannot respond to antigen and never emigrate from the thymus. Quantitative analysis of rearrangements in total adult thymocyte DNA shows that beta gene rearrangements generally occur on both chromosomal homologs, and that rearrangements occur preferentially to the J beta 2 gene segment cluster.
Serologic Detection of Gonorrhea
Authors: B. B. DIENA
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 July 1971Serologic Detection of GonorrheaB. B. DIENA, PH.D., M.V.D.B. B. DIENA, PH.D., M.V.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-1-135_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have read with great interest the editorial by Dr. Schmale on the serologic detection of gonorrhoea (Ann Intern Med72:593-595, 1970) and the need for a rapid, inexpensive, epidemiological screening test. I would like to add the following comments to the communication of Dr. Schmale.It is of great importance in all the suggested tests for the serodiagnosis of gonorrhoea that the specificity of the test be very high, with minimum cross-reactivity to antibodies evoked by other bacteria, such as meningococci and staphylococci. In the bentonite flocculation test that we have developed (Wallace et al.,Canad J... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1971Volume 75, Issue 1Page: 135-135KeywordsAntibodiesBacteriaGonorrheaSerodiagnosisSpecificity Issue Published: 1 July 1971 PDF DownloadLoading ...
The Medical Society of London 1773-2003
Authors: M D O'Brien
Journal: BMJ (2004)

T he Medical Society of London is the oldest extant medical society in England and possibly in the world, the only one of numerous medical societies formed in the 18th century to survive. It was founded in 1773 by John Coakley Lettsom, a Quaker born on Tortola in the British Virgin Islands, who came to England at the age of 6 for a Quaker education in Lancashire, where the preacher Samuel Fothergill became his guardian.
In vivo evidence of oral vaccination with PLGA nanoparticles containing the immunostimulant monophosphoryl lipid A
Authors: Federica Sarti, Glen Perera, Fabian Hintzen, Katerina Kotti, Vassilis Karageorgiou, Olga Kammona, Costas Kiparissides, Andreas Bernkop-Schnürch
Journal: Biomaterials (2011)
The Rational Clinical Examination
Authors: David H. Spodick
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Many of us have high hopes for the series<i>JAMA</i>will publish on the science and art of clinical examination<sup>1</sup>because our traditional methods require objectification and reevaluation in the light of continuous acquisition of knowledge. I hope the authors will emphasize those elements that have been not only tested by verifiable standards, but also by appropriately designed observer variability studies. Time-honored methods can become time-dishonored when subjected to closer scrutiny. For example, there is only one interobserver study of the bedside estimation of aortic stenosis via the rate of rise of the carotid pulse.<sup>2</sup>In prospective, mutually blinded, sequential examinations of patients referred to an echocardiographic laboratory, three well-trained observers could not reach any statistically significant agreements. Moreover, there was no agreement with quantitative measurements of the blindly recorded carotid displacement pulse.<sup>2</sup>This study engendered no controversy even in the journal's active letters
Nodular Lesion of Diaphragm
Authors: Frank J. Gallia
Journal: JAMA (1968)

Dr. Frank J. Gallia: This 54-year-old woman experienced pain in the right side of her chest approximately one week prior to admission. The pain was pleuritic in nature and was thought to be secondary to pleurodynia. The pain disappeared in two days. She has had none since. During evaluation, a routine chest roentgenogram was obtained which showed a nodular lesion in the region of the cardiophrenic angle on the right (Fig 1). The patient does not smoke and has had no industrial exposure to noxious agents. All laboratory studies obtained were within normal limits. <h3>Discussion</h3> Dr. Laurence L. Robbins: Do you see anything of interest, Dr. Hanelin? Dr. Joseph Hanelin: There is a small lesion at the right base medially. In the lateral view it appears to lie halfway back, adjacent to the dome of the diaphragm. One consideration is a small hernia. I would like to see a laminagraphic
Mast Cells Expressing the Germline HPS1 16-Bp Duplication (c.1470_1486dup16, Hermansky-Pudlak Syndrome-1) Defect Produce Extracellular Matrix Components
Authors: Arnold S. Kirshenbaum, Geethani Bandara, Avanti Desai, Elizabeth Fischer, Maarten Leerkes, Dean D. Metcalfe, Glenn Cruse
Journal: Journal of Allergy and Clinical Immunology (2015)
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.
Authors: D Kunz, G Walker, W Eberhardt, U K Messmer, A Huwiler, J Pfeilschifter
Journal: Journal of Clinical Investigation (1997)

Platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) regulate mesangial cell proliferation and matrix production in vitro and in vivo and crucially participate in the pathogenesis of glomerulonephritis. We investigated whether PDGF-BB and bFGF influence nitric oxide (NO) production, another important effector molecule in inflammatory glomerular injury. Inducible NO synthase (iNOS) induction in rat glomerular mesangial cells has been described in response to two principal classes of activating signals comprising inflammatory cytokines such as interleukin 1beta (IL-1beta) or elevation of cyclic AMP (cAMP). Treatment of mesangial cells with IL-1beta induces iNOS activity measured as nitrite levels in cell culture supernatants. Coincubation of mesangial cells with PDGF-BB inhibits production of nitrite by approximately 95%. This effect can be reversed by the simultaneous incubation of PDGF-BB in the presence of calphostin C, a potent and selective inhibitor of protein kinase C. In contrast, incubation of cells in the presence of bFGF potentiates IL-1beta-induced production of NO and is functionally associated with an increased rate of apoptosis of mesangial cells. Western blot analyses reveal that PDGF-BB causes a decrease in the formation of iNOS protein which is preceded by decreases in iNOS mRNA steady state levels. bFGF drastically increases iNOS protein levels as well as the corresponding iNOS mRNA steady state levels. Nuclear run-on experiments reveal that PDGF-BB decreases the IL-1beta-induced transcription rate of the iNOS gene, whereas bFGF potentiates the transcriptional activity of the iNOS gene. Northern blot analyses demonstrate that bFGF strongly potentiates the formation of IL-1beta-induced IL-1 type I receptor mRNA levels, whereas PDGF-BB has no effect. Treatment of mesangial cells with the membrane-permeable cAMP analogue N6, O-2'-dibutyryladenosine 3',5'-phosphate (Bt2cAMP) markedly increases the production of nitrite. Whereas PDGF-BB does not affect cAMP-induced nitrite levels, bFGF strongly potentiates them. PDGF-BB alters neither cAMP-induced iNOS protein levels nor the corresponding iNOS mRNA steady state levels. By contrast, bFGF superinduces cAMP-stimulated iNOS protein and iNOS mRNA levels. These changes by bFGF are due to an increase in cAMP-induced transcriptional activity of the iNOS gene which is not affected by PDGF-BB. In summary, the results show that PDGF and bFGF differentially regulate iNOS expression in mesangial cells in a stimulus-specific way. The timely sequence of expression of PDGF and bFGF and of cytokines like IL-1 will crucially determine the amounts of NO produced and the functional consequences thereof in the course of progressive glomerular diseases.
Pseudotumor Cerebri Syndrome Without Papilledema
Authors: Howard L. Lipton, Paul E. Michelson
Journal: JAMA (1972)

An obese, young woman exhibited the classical features of pseudotumor cerebri syndrome, including increased intracranial pressure, normal cerebrospinal fluid and ventricular system, and absence of focal neurologic signs. Despite elevated intracranial pressure of sufficient magnitude to produce bilateral sixth-nerve palsy, papilledema did not develop. The illness resolved spontaneously and on examination 1 1/2 years later, the patient was normal. There are several possible mechanisms that might prevent papilledema from developing under these circumstances.
Changing the nomenclature: fashion or necessity?
Authors: Paul Van Cauwenberge
Journal: Allergy (2001)

In the current issue of Allergy the European Academy of Allergology and Clinical Immunology publish their position paper concerning nomenclature in allergology. It was already some time ago that the nomenclature was adapted, and it was felt by some EAACI members that in view of the increased knowledge about the allergological mechanisms, and the sometimes confusing terminology used today by allergologists and organ specialists, a revision of the nomenclature was necessary. The main aim of the task force responsible for the position paper was to try to harmonise the existing terminology and to get rid of terms that are obviously not anymore in line with the actual knowledge about the pathophysiology involved. Some terms are already in use since at least a century (and sometimes a millennium) and thus a long time before it was known what the basic mechanisms of disease were. Examples are asthma, hay fever and eczema. Hay fever is, in fact, a totally wrong term, which is not used anymore in professional medical language, but still persists in the lay language. Asthma and eczema are terms that do not really tell us something about the etio- or pathophysiology of the disease, but they describe a certain syndrome of symptoms that everybody understands. There are, of course, at regular intervals some finer identifications of the definition of these diseases, but in general these terms became an inherent part of the medical nomenclature. Asthma and eczema will not easily disappear from the medical vocabulary, because they do not evoke any wrong perception. The task force had most difficulties with the definition of “atopy” and “atopic dermatitis”. These terms are so wide spread, like “hay fever”, although most of the time erroneous, that it was difficult to redefine their real meaning or to find other terms that can replace them. When “atopy” is defined in a specific way, all terms with the prefix “atopic” should be in line with the definition of atopy. However, it is the task of every scientific society, such as EAACI, to assure a correct terminology, no matter how difficult it may be to question the correctness of long existing and widely used terminology. An additional difficulty in defining terms related to allergy is that allergology is a horizontal speciality, involving a whole series of “vertical” or organ specialities. This implies a close collaboration between the specialists of the various disciplines concerned. To obtain this goal, representatives of all specialities were actively involved in the task force along with allergologists and clinical immunologists. Finally, it does not make much sense to write a position paper on nomenclature for a particular continent, such as Europe, if the nomenclature is not applied to the whole world. Therefor, we hope that this document will form the basis for a world-wide task force establishing a nomenclature that can be used in the whole world.