Trimethoprim-Sulfamethoxazole Desensitization in the Acquired Immunodeficiency Syndrome
Authors: R. Maclean Smith, Gary K. Iwamoto, Hal B. Richerson, John P. Flaherty
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 February 1987Trimethoprim-Sulfamethoxazole Desensitization in the Acquired Immunodeficiency SyndromeR. MACLEAN SMITH, M.D., GARY K. IWAMOTO, M.D., HAL B. RICHERSON, M.D., JOHN P. FLAHERTY, M.D.R. MACLEAN SMITH, M.D.Search for more papers by this author, GARY K. IWAMOTO, M.D.Search for more papers by this author, HAL B. RICHERSON, M.D.Search for more papers by this author, JOHN P. FLAHERTY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-2-335_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Pneumonia due toPneumocystis cariniimay occur as an opportunistic infection in patients with the acquired immunodeficiency syndrome (AIDS). Trimethoprim-sulfamethoxazole has been used effectively for treatment or prophylaxis of pneumocystis infections. Gordin and colleagues (1), however, have reported that the frequency of adverse reactions to these drugs is greater in patients with AIDS than in other patient populations. The adverse reactions include skin rash, fever, neutropenia, thrombocytopenia, and aminotransferase elevations. The reason for the higher rate of adverse reactions is not known, but a history of an adverse reaction to trimethoprim-sulfamethoxazole may preclude its use for prophylaxis...References1. GORDINSIMONWOFSYMILLS FGCJ. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1984;100:495-9. LinkGoogle Scholar2. HOLDSWORTH C. Sulphasalazine desensitisation. Br Med J [Clin Res]. 1981;282:110-1. CrossrefMedlineGoogle Scholar3. PURDYPHILIPSSUMMERS BDR. Desensitization for sulfasalazine skin rash. Ann Intern Med. 1984;100:512-4. LinkGoogle Scholar4. BELLTAPPERPOLLOCK EMA. Sulphadiazine desensitization in AIDS patients. Lancet. 1985;1:163. CrossrefMedlineGoogle Scholar5. HUGHESALMGRENMCGUFFINOMOTO TJRR. Co-trimoxazole desensitization in bone marrow transplantation [Letter]. Ann Intern Med. 1986;105:148. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Iowa Hospitals and Clinics Iowa City, IA 52242 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNocardia SpeciesDrug AllergySuccessful Outpatient Graded Administration of Trimethoprim-Sulfamethoxazole in Patients Without HIV and With a History of Sulfonamide Adverse Drug ReactionDesensitization in delayed drug hypersensitivity reactions - an EAACI position paper of the Drug Allergy Interest GroupNocardia SpeciesDrug AllergyDesensitization to imatinib in patients with leukemiaManagement of cutaneous drug reactionsDIAGNOSTIC TESTING FOR DRUG HYPERSENSITIVITYIN VIVO AND IN VITRO TESTING FOR ADVERSE DRUG REACTIONSManagement of adverse reactions to prophylactic trimethoprim-sulfamethoxazole in patients with human immunodeficiency virus infectionHIV-Infektion und Kaposi-SarkomDesensitization to trimethoprim/sulfamethoxazole in HIV-infected patientsMEDICAL EVALUATION OF THE ADULT WITH HIV INFECTIONTOXOPLASMOSIS IN INDIVIDUALS WITH AIDSISSUES IN TOXOPLASMOSISProphylaxis of Pneumocystis carinii pneumonia in patients with HIV infectionPrevention and Treatment of Pneumocystis PneumoniaTrimethoprim-Sulfamethoxazole Induced Neutropenia and Dermatologic Reactions in Patients With Acquired Immunodeficiency SyndromeDrug allergyCan the course of high dose cotrimoxazole for Pneumocystis carinii pneumonia in AIDS be shorter? A possible solution to the problem of cotrimoxazole toxicityPneumocystis cariniiTrimethoprim-sulfamethoxazole desensitization in AIDSAllergic Drug Reactions 1 February 1987Volume 106, Issue 2Page: 335-335KeywordsAIDSAdverse reactionsFeversNeutropeniaOpportunistic infectionsPneumocystisPneumoniaPopulation statisticsProphylaxisRashes ePublished: 1 December 2008 Issue Published: 1 February 1987 PDF downloadLoading ...