New Directions in the Immunology of Autoimmune Diabetes
Authors: Kevan C. Herold, Arthur H. Rubenstein
Journal: Annals of Internal Medicine (1992)

Editorials1 September 1992New Directions in the Immunology of Autoimmune DiabetesKevan C. Herold, MD, Arthur H. Rubenstein, MDKevan C. Herold, MDSearch for more papers by this author, Arthur H. Rubenstein, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-5-436 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough it has been recognized for several years that insulin-dependent diabetes mellitus is a chronic autoimmune disease (1), it has only recently been possible to identify antigens involved in the disease and to study possible precipitating events, the genetic determinants underlying the disorder, and its pathogenesis. Studies of concordant twins and triplets have shown evidence of autoimmunity toward islet cells as early as 7 to 10 years before the clinical presentation of the disease, even when oral glucose tolerance was normal (2). Other data have confirmed the appearance of autoantibodies before clinical presentation (3), and, on the basis of these...References1. Eisenbarth G. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med. 1986;314:1360-8. CrossrefMedlineGoogle Scholar2. SrikantaGandaEisenbarthSoeldner SOGJ. Islet-cell antibodies and beta-cell function in monozygotic twins initially discordant for Type I diabetes mellitus. N Engl J Med. 1983;308:322-5. CrossrefMedlineGoogle Scholar3. RileyMaclarenKrischerSpillarSilversteinSchatz WNJRJD. A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med. 1990;323:1167-72. CrossrefMedlineGoogle Scholar4. JohnsonCriderMcCorkleAlfordUnger JBKMR. 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CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The University of Chicago Chicago, IL 60637 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Autoimmune EndocrinopathiesThe Neuronal Toxic Factor in Serum of Type 1 Diabetic Patients is a Complement-fixing Autoantibody 1 September 1992Volume 117, Issue 5Page: 436-438KeywordsAutoimmune diseasesDiabetes mellitusGenetic diseasesInterleukinsOral diseasesOral glucose tolerance testPathogenesisResearch grantsTwinsType 1 diabetes Issue Published: 1 September 1992 PDF DownloadLoading ...