AL Amyloidosis Combined with Acquired Factor V Deficiency
Authors: Anne Gatel
Journal: Annals of Internal Medicine (1998)

Letters1 April 1998AL Amyloidosis Combined with Acquired Factor V DeficiencyAnne Gatel, Patrice Cacoub, MD, and Jean Charles Piette, MDAnne GatelLa Pitie Salpetriere Hopital; Paris, France, Patrice Cacoub, MDLa Pitie Salpetriere Hopital; Paris, France, and Jean Charles Piette, MDLa Pitie Salpetriere Hopital; Paris, FranceAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Many coagulation disorders have been described in patients with AL amyloidosis (for example, factor X deficiency, factor IX deficiency, and disseminated intravascular coagulation). We report the first case of AL amyloidosis combined with acquired factor V deficiency.In May 1990, a 33-year-old man had splenectomy after polytraumatism. The prothrombin rate was 91%. In August 1994, gastrointestinal hemorrhage occurred. The surgeon found a voluminous hematoma of the lesser peritoneal sac, but laparotomy and gastrointestinal endoscopy could not trace the origin of the bleeding. The prothrombin rate was 35%, factor V level was 25%, and antiprothrombinase antibody was present. ...References1. Furie B, Greene E, Furie BC. Syndrome of acquired factor X deficiency and systemic amyloidosis: in vivo studies of the metabolic fate of factor X. N Engl J Med. 1977; 297:81-5. Google Scholar2. Furie B, Voo L, Keith PW, McAdam J, Furie BC. Mechanism of factor X deficiency in systemic amyloidosis. N Engl J Med. 1981; 304:827-30. Google Scholar Author, Article, and Disclosure InformationAuthors: Anne Gatel; Patrice Cacoub, MD; Jean Charles Piette, MDAffiliations: La Pitie Salpetriere Hopital; Paris, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevalence, clinical characteristics and treatment outcome of factor X deficiency in a consecutive cohort of primary light-chain amyloidosisCoagulation Abnormalities in Light Chain AmyloidosisImmunoglobulin Light Chain Amyloidosis with Severe Liver Dysfunction Accompanied by Factor X DeficiencyPrevalence and prognostic value of D‐dimer elevation in patients with AL amyloidosisAcquired Factor X Deficiency in Patients With Primary Light Chain AmyloidosisAcquired factor V deficiency in a patient with myeloma and amyloidosisFactor X deficiency: An uncommon presentation of AL amyloidosisSystemic AL amyloidosis with disseminated intravascular coagulation associated with hyperfibrinolysisSpontaneous atraumatic rupture of a normal-sized spleen due to AL amyloid angiopathyAssociation of acquired von Willebrand syndrome with AL amyloidosisAL cardiac amyloidosis and arterial thromboembolic eventsSpontaneous rupture of the spleen in AL amyloidosisLife-threatening bleeding and acquired factor V deficiency associated with primary systemic amyloidosisCase 6-2002Anticoagulant acquis antifacteur V : nosologie, risque hémorragique et prise en charge thérapeutique à propos de trois observationsAcquired factor X deficiency in patients with amyloid light-chain amyloidosis: incidence, bleeding manifestations, and response to high-dose chemotherapyBleeding symptoms and coagulation abnormalities in 337 patients with AL-amyloidosis 1 April 1998Volume 128, Issue 7Page: 604-605KeywordsAmyloidosisBiopsyBlood plasmaDisseminated intravascular coagulationGastrointestinal hemorrhageHemorrhageLiverMyelomaPlateletsVeins ePublished: 15 August 2000 Issue Published: 1 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...