Surgical and Anticoagulant Therapy of Occlusive Cerebrovascular Disease
Authors: ROBERT G. SIEKERT
Journal: Annals of Internal Medicine (1963)

Article1 April 1963Surgical and Anticoagulant Therapy of Occlusive Cerebrovascular DiseaseROBERT G. SIEKERT, M.D., F.A.C.P., JACK P. WHISNANT, M.D., CLARK H. MILLIKAN, M.D., F.A.C.PROBERT G. SIEKERT, M.D., F.A.C.P., JACK P. WHISNANT, M.D., CLARK H. MILLIKAN, M.D., F.A.C.PAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-637 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapy of patients with focal ischemic cerebrovascular disease continues to be a challenge. Each regimen must be considered carefully in regard to its immediate therapeutic effect, its long-term prophylactic effect, and any risks attendant on its use. Meaningful comparisons between treated and untreated patients are extremely difficult to make. It is essential in any study that the investigator defines carefully the patients analyzed and the larger group from which they were selected, and takes into account variations in the natural course of the disease. The present report concerns our experience to date with anticoagulant and surgical therapy.DEFINITIONSThe...References1. DEBAKEYCRAWFORDFIELDS MEESWS: Results of surgical therapy, in Cerebral Vascular Diseases, ed. by Siekert, R. G., and Whisnant, J. P., Grune & Stratton, Inc., New York, 1961, pp. 113-132. Google Scholar2. GROCHMCDEVITTWRIGHT SNEIS: A long-term study of cerebral vascular disease. Ann. Intern. Med. 55: 358, 1961. LinkGoogle Scholar3. THOMES AB: Prophylactic value of anticoagulant therapy in cerebral thrombosis. Minnesota Med. 42: 1587, 1959. MedlineGoogle Scholar4. MILLIKANSIEKERTWHISNANT CHRGJP: Anticoagulant therapy in cerebral vascular disease: current status. JAMA 166: 587, 1958. CrossrefMedlineGoogle Scholar5. CARTER AB: Anticoagulant therapy, in Cerebral Vascular Diseases, ed. by Siekert, R. G., and Whisnant, J. P., Grune & Stratton, Inc., New York, 1961, pp. 151-159. Google Scholar6. WISIOLFRENCHCHOU ESLASN: Carotid endarterectomy. Minnesota Med. 45: 257, 1962. MedlineGoogle Scholar7. SIEKERT RG: Evaluation of anticoagulant therapy in focal ischemic cerebrovascular disease: further observations. Res. Publ. Ass. Res. Nerv. Ment. Dis. In press. Google Scholar8. WHISNANTELLIS JPFH: Surgical treatment of occlusive cerebrovascular disease. Res. Publ. Ass. Res. Nerv. Ment. Dis. In press. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT G. SIEKERT, M.D., F.A.C.P.; JACK P. WHISNANT, M.D.; CLARK H. MILLIKAN, M.D., F.A.C.PAffiliations: Rochester, MinnesotaFrom the Section of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota.Presented at the Forty-third Annual Session of the American College of Physicians, April 9-13, 1962, Philadelphia, Pennsylvania.Requests for reprints should be addressed to Mayo Clinic, Rochester, Minnesota. 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A follow-up studyItalian multicenter study on reversible cerebral ischemic attacks: VI--Prognostic factors and follow-up results.Pharmacologic Approach to Ischemic Stroke ManagementAnticoagulant-induced intracerebral bleeding in brain ischemiaEnteric-coated acetylsalicylic acid plus dipyridamole compared with anticoagulants in the prevention of ischemic events in patients with transient ischemic attacksStroke-in-evolution an indication for an emergency extracranial-intracranial bypassAntithrombotic Therapy in Ischemic Cerebrovascular DiseaseCarotid EndarterectomyOral Anticoagulants in the Prevention and Treatment of Vascular DisordersCarotid endarterectomy: does it work?Dipyridamole: A Critical EvaluationThe Underlying Problems Resulting in Controversies in the Clinical Management of Transient Ischemic Attacks: An OverviewDiagnosis and management of ischemic stroke Part I. — Threatened stroke and its managementThe role of the neurologist in the decline of strokeThe current status of carotid artery surgeryModulation of the pathophysiology of primate focal cerebral ischaemia by indomethacin.Transient ischemic attacks and strokes with recovery prognosis and investigation.RANDOMISED TRIAL OF PENTOXIFYLLINE VERSUS ACETYLSALICYLIC ACID PLUS DIPYRIDAMOLE IN PREVENTING TRANSIENT ISCHAEMIC ATTACKSResults from 88 consecutive prophylactic carotid endarterectomies in cerebral infarction and transitory ischemic attacksTherapy of Ischemic Cerebrovascular DiseaseJOHN A. 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MANAGEMENTTreatment of transient ischemic attacks.Clinical features and long-term follow-up of patients with reversible ischemic attacks (RIA)Clinical and Angiographic Features of Carotid Transient Ischemic AttacksRECONSTRUCTION OF VERTEBRAL ARTERY STENOSIS 1XIV. Cerebral ischemia: the role of thrombosis and of antithrombotic therapy. Study group on antithrombotic therapy.Current status of antithrombotic therapy in cardiovascular diseaseLong-term anticoagulant therapy for TIAs and minor strokes with minimum residuum.Temporal profile (clinical course) of acute carotid system cerebral infarction.JOINT COMMITTE FOR STROKE FACILITIESCerebrovascular diseaseTRANSIENT CEREBRAL ISCHEMIC ATTACKSIntermittierende zerebrale InsuffizienzRisk Factors in Stroke Due to Cerebral InfarctionComparison of Anticoagulation and Surgical Treatments of TIA. A Review and Consolidation of Recent Natural History and Treatment StudiesReassessment of Anticoagulant Therapy in Various Types of Occlusive Cerebrovascular DiseaseAngina cerebri. Part IIAtherosclerotic cerebrovascular disease —Its nature and managementCarotid endarterectomy in cerebral vascular diseaseCarotid EndarterectomyOcclusions and Aneurysms of the Cervical Carotid Arteries 1 April 1963Volume 58, Issue 4 Page: 637-641 Keywords Anticoagulant therapy Anticoagulants Cerebrovascular diseases Neurology ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...