Tamoxifen and Purpuric Vasculitis
Authors: Francesco Drago
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 June 1990Tamoxifen and Purpuric VasculitisFrancesco Drago, MD, Mariarosa Arditi, MD, Alfredo Rebora, MDFrancesco Drago, MDSearch for more papers by this author, Mariarosa Arditi, MDSearch for more papers by this author, Alfredo Rebora, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-12-965_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Cutaneous adverse reactions to tamoxifen are very rare. We report a case in which tamoxifen appeared to cause purpuric vasculitis. A 56-year-old woman presented with a 15-month history of recurrent purpuric lesions. Eleven years earlier she had had breast surgery with axillary lymphadenectomy for cancer and 4 years later she had been diagnosed as having an osteolysis of the second costa. Ovariectomy and radiotherapy of the bone lesion were done. Treatment with tamoxifen (20 mg/d) had been started 6 months before the onset of the skin lesions.She had several purpuric papular lesions on her legs, with...References1. KiangKennedy DB. Tamoxifen (antiestrogen) therapy in advanced breast cancer. Ann Intern Med. 1977;87:687-90. LinkGoogle Scholar2. SwenertonShawWhiteBoyles KDGD. Treatment of advanced endometrial carcinoma with tamoxifen. N Engl J Med. 1979;105:301. Google Scholar3. El-Arini O. Response to tamoxifen in drug-resistant prostatic carcinoma. Lancet. 1979;2:588. CrossrefMedlineGoogle Scholar4. CreaganIngleAhmannGreen EJDS. Phase II study of high-dose tamoxifen in patients with disseminated malignant melanoma. Cancer. 1982;49:1353-4. CrossrefMedlineGoogle Scholar5. AshfordDonevTiwariGarrett AIRT. Reversible ocular toxicity related to tamoxifen therapy. Cancer. 1988;61:33-5. CrossrefMedlineGoogle Scholar6. LeghaPowellBuzdarBlumenschein SKAG. Tamoxifen-induced hypercalcemia in breast cancer. Cancer. 1981;47:2803-6. CrossrefMedlineGoogle Scholar7. DahanEspieMignotHoulbertChanu RMLDB. Tamoxifen and arterial thrombosis. Lancet. 1985;1:638. CrossrefMedlineGoogle Scholar8. Bruinsma W. A Guide to Drug Eruptions. Oosthuizen, the Netherlands: The File of Medicines; 1987:93. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Genoa 7-16132 Genoa, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBreast Cancer with IgA Vasculitis due to Endocrine Therapy in an Elderly Female Undergoing Postoperative—A Case Report—Vascularites médicamenteuses : à propos d’une série de 13 casTamoxifen-associated skin reactions in breast cancer patients: from case report to literature reviewCutaneous adverse effects of hormonal adjuvant therapy for breast cancer: A case of localised urticarial vasculitis following anastrozole therapy and a review of the literatureA Case of Vasculitis in a Breast Cancer Patient Treated With T-DM1Adverse reactions to targeted and non-targeted chemotherapeutic drugs with emphasis on hypersensitivity responses and the invasive metastatic switchEndocrine AgentsMyelodysplasia and Malignancy-Associated VasculitisCutaneous small-vessel vasculitis associated with solid organ malignancies: The Mayo Clinic experience, 1996 to 2009Cutaneous vasculitis in breast cancer treated with chemotherapyTamoxifen and purpuric vasculitis: a case reportTamoxifen-associated vasculitis in a breast cancer patientErythema nodosum secondary to aromatase inhibitor use in breast cancer patients: case reports and review of the literatureHenoch–Schönlein purpura (HSP) during treatment with anastrozolePúrpura cutánea en relación con tamoxifenoCutaneous and Systemic Manifestations of Drug-Induced VasculitisParaneoplastic rheumatic syndromesVasculitis and MalignancyMucocutaneous reactions to chemotherapyVasculitis confined to the peripheral nerve and skin: a variant of non-systemic vasculitic neuropathyCutaneous Necrotizing VasculitisCutaneous small-vessel vasculitisCUTANEOUS NECROTIZING VASCULITISPurpuras and related conditionsCancer-associated rheumatic disordersclues to occult neoplasiaDigital gangrene following chemotherapy 15 June 1990Volume 112, Issue 12Page: 965-966KeywordsAdverse reactionsBoneLesionsLymphadenectomySurgeryVasculitis Issue Published: 15 June 1990 PDF DownloadLoading ...