Resolution of Musculoskeletal Symptoms in the Carcinoid Syndrome after Treatment with the Somatostatin Analog Octreotide
Authors: Sidney Smith
Journal: Annals of Internal Medicine (1990)

Brief Reports1 January 1990Resolution of Musculoskeletal Symptoms in the Carcinoid Syndrome after Treatment with the Somatostatin Analog OctreotideSidney Smith, MD, Lowell Anthony, MD, L. Jackson Roberts, MD, John A. Oates, MD, Theodore Pincus, MDSidney Smith, MDSearch for more papers by this author, Lowell Anthony, MDSearch for more papers by this author, L. Jackson Roberts, MDSearch for more papers by this author, John A. Oates, MDSearch for more papers by this author, Theodore Pincus, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-1-66 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCarcinoid tumors are neoplasms of the enterochromaffin cells, the primary clinical manifestations of which include flushing, diarrhea, cardiac valvular lesions, and carcinoid crises with bronchospasm and hypotension (1). The acute symptoms are inhibited by the long-acting octapeptide analog of somatostatin, octreotide (SMS-201-995) (2). Musculoskeletal symptoms have been reported (3) in patients with the carcinoid syndrome, although this problem has not been widely recognized. We describe three patients with the carcinoid syndrome in whom treatment with octreotide was followed by resolution of their musculoskeletal symptoms.Patient 1A white woman born in 1920 had metastatic carcinoid tumor noted as an incidental...References1. Oates J. The carcinoid syndrome [Editorial]. N Engl J Med. 1986;315:702-4. CrossrefMedlineGoogle Scholar2. KvolsMoertelO'ConnellSchuttRubinHahn LCMAJR. Treatment of the malignant carcinoid syndrome. Evaluation of a long-acting somatostatin analogue. N Engl J Med. 1986;315:663-6. CrossrefMedlineGoogle Scholar3. PlonkFeldman JJ. Carcinoid arthropathy. Arch Intern Med. 1974;134:651-4. CrossrefMedlineGoogle Scholar4. PeltonGulyaHrubyDuckiesYamamura JKVSH. Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity. Proc Natl Acad Sci USA. 1985;82:236-9. CrossrefMedlineGoogle Scholar5. BarnardGranthamLambertonO'DorisioJackson LWPTI. Treatment of resistant acromegaly with long-acting somatostatin analogue (SMS 201-995). Ann Intern Med. 1986;105:856-61. LinkGoogle Scholar6. Matucci-Cerinic M. Response of hypertrophic osteoarthropathy to drugs inhibiting growth hormone [Letter]. J Rheumatol. 1984;11:865-6. MedlineGoogle Scholar7. Matucci-CerinicLottiCappugiBoddiFattoriniPanconesi MTPVLE. Somatostatin treatment of psoriatic arthritis. Int J Dermatol. 1988;27:56-8. CrossrefMedlineGoogle Scholar8. DenkoGabriel CP. Effects of peptide hormones in urate crystal inflammation. J Rheumatol. 1985;12:971-5. MedlineGoogle Scholar9. LygrenOstensenBurholHusby IMPG. Gastrointestinal peptides in serum and synovial fluid from patients with inflammatory joint disease. Ann Rheum Dis. 1986;45:637-40. CrossrefMedlineGoogle Scholar10. Smythe H. "Fibrositis" and other diffuse musculoskeletal disease. In: Kelly WN, Harris ED Jr, Ruddy S, Sledge CB, eds. Textbook of Rheumatology. Philadelphia: W.B. Saunders; 1985:481-9. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Vanderbilt University School of Medicine and the Veterans Affairs Hospital, Nashville, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA Case of Multicentric Carcinoid in a Patient with Psoriatic SpondyloarthropathySomatostatin and somatostatin receptors: implications for neoplastic growth and cancer biologyParaneoplastic neurological syndromes in patients with carcinoidThe clinical role of somatostatin analogues as antineoplastic agents: much ado about nothing?Paraneoplastic syndromes of the spinal cord, nerve, and muscleOctreotide Dependency and Headache: A Case ReportOctreotide in the Treatment of Disorders of the Gastrointestinal SystemAnalgesic effect of octreotide in headache associated with acromegaly is not mediated by opioid mechanisms. Case reportSomatostatin and octreotide in gastroenterologyMiscellaneous hormonesTreatment of the Eosinophilia–Myalgia SyndromeEosinophilia-myalgia syndrome due to l-tryptophan ingestion: report of four cases and review of the Maryland experience 1 January 1990Volume 112, Issue 1Page: 66-68KeywordsCarcinoid tumorEnterochromaffinHospital medicineHypotensionImmunologyLesionsMuscular dystrophiesResearch grantsRheumatologySomatostatin Issue Published: 1 January 1990 PDF DownloadLoading ...