Platelet Survival and Sequestration Studies in Idiopathic Thrombocytopenic Purpura
Authors: SCOTT MURPHY
Journal: Annals of Internal Medicine (1974)

Editorials1 June 1974Platelet Survival and Sequestration Studies in Idiopathic Thrombocytopenic PurpuraSCOTT MURPHY, M.D., FRANK H. GARDNER, M.D.SCOTT MURPHY, M.D.Search for more papers by this author, FRANK H. GARDNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-6-768 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe paper by Ries and Pierce, in this issue of the ANNALS, raises questions concerning the proper management of adult patients with idiopathic thrombocytopenic purpura and other clinical syndromes that mimic it. The clinician frequently sees a patient with thrombocytopenia and normal or increased numbers of megakaryocytes in a bone marrow smear that is otherwise normal. The diagnosis of idiopathic thrombocytopenic purpura should be made if other mimicking syndromes can be excluded. Many drugs can produce these clinical features. Although the most common offenders are quinidine, the sulfanilamides, and the thiazides, in practice, all drugs should be eliminated and the...References1. SHULMAN N, MARDER V, and WEINRACH R: Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura. Physiologic, serologic and isotopic studies. Ann NY Acad Sci 124:499-542, 1965 CrossrefMedlineGoogle Scholar2. KARPATKIN S, STRICK N, and SISKIND G: Detection of splenic antiplatelet antibody synthesis in idiopathic autoimmune thrombocytopenic purpura (ATP). Br J Haematol 23:167-176, 1972 CrossrefMedlineGoogle Scholar3. MCMILLAN R, LONGMIRE R, and YELENOSKY R: Immunoglobulin synthesis in vitro by splenic tissue in idiopathic thrombocytopenic purpura. N Engl J Med 286:681-684, 1972 CrossrefMedlineGoogle Scholar4. ERAKLIS A, KEVY S, and DIAMOND L: Hazard of overwhelming infection after splenectomy in childhood. N Engl J Med 276:1225-1229, 1967 CrossrefMedlineGoogle Scholar5. KARPATKIN S and SISKIND G: In vitro detection of platelet antibody in patients with idiopathic thrombocytopenic purpura and systemic lupus erythematosus. Blood 33:795-812, 1969 CrossrefMedlineGoogle Scholar6. HIRSCHMAN R and SHULMAN N: The use of platelet serotonin release as a sensitive method for detecting anti-platelet antibodies and a plasma anti-platelet factor in patients with idiopathic thrombocytopenic purpura. Br J Haematol 24:793-802, 1973 CrossrefMedlineGoogle Scholar7. HANDIN R, PIESSENS W, and MOLONEY W: Stimulation of non-immunized lymphocytes by platelet-antibody complexes in idiopathic thrombocytopenic purpura. N Engl J Med 289:714-718, 1973 CrossrefMedlineGoogle Scholar8. ASTER R and KEENE W: Sites of platelet destruction in idiopathic thrombocytopenic purpura. Br J Haematol 16:61-73, 1969 CrossrefMedlineGoogle Scholar9. NAJEAN Y and ARDAILLOU N: The sequestration site of platelets in idiopathic thrombocytopenic purpura: its correlation with the results of splenectomy. Br J Haematol 21:153-164, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SCOTT MURPHY, M.D.; FRANK H. GARDNER, M.D.Affiliations: Hematology Research Laboratory Presbyterian-University of Pennsylvania Medical Center Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and functionBausteine zu einer Theorie der Reformkonjunktur I: Idealtypische Verlaufsmuster eines Reformzyklus 1 June 1974Volume 80, Issue 6 Page: 768-769 Keywords Bone marrow Drugs Idiopathic thrombocytopenic purpura Megakaryocytes Platelets ePublished: 1 December 2008 Issue Published: 1 June 1974 PDF downloadLoading ...