tbuckley/cabot-search huggingface dataset:
Penicillamine-induced myasthenia in rheumatoid arthritis: its clinical and genetic features.
Authors: J P Delamere, S Jobson, L P Mackintosh, L Wells, K W Walton
Journal: Annals of the Rheumatic Diseases (1983)

The clinical features and genetic background of 18 patients with rheumatoid arthritis were investigated following the development of penicillamine-induced myasthenia (PIM). The initial myasthenia symptoms in all patients consisted of variable diplopia and/or ptosis with progression to a more generalized involvement in 7 of them. No clinical, humoral, or genetic factor was determined which would allow identification of individuals developing generalized as opposed to ocular myasthenia. Withdrawal of penicillamine was associated over 4-60 weeks with a slow resolution of symptoms, facilitated in 12 patients by the use of anticholinesterase agents. In 2 patients a persistent partial unilateral ptosis remains after 15 and 25 months, while in a further patient diplopia is present 42 months after resolution of the other myasthenic symptoms. The patients with PIM when compared with a healthy 9control9 population had a significant increase in HLA Dr1 (p corr less than 0.005) and an absence of HLA Dr 3. A genetic susceptibility to the development of PIM, distinct from that observed in myasthenia gravis of spontaneous onset, is suggested by this abnormal distribution of HLA Dr antigens.
A Core Medical Library for Practitioners in Community Hospitals
Authors: Norman S. Stearns, Wendy W. Ratcliff
Journal: New England Journal of Medicine (1969)

IN an ongoing study designed in part to evaluate and encourage continuing education programs in community hospitals1 Postgraduate Medical Institute (PMI)† has determined that there is need for guidance in the area of medical-library development. Reports from PMI physician consultants who visited more than 40 community hospitals indicate that medical-library facilities are generally poor and infrequently used by physicians. The basic weaknesses of these libraries fall into four categories: inadequate collections, inadequate personnel, inadequate space, and the absence of any practical indexing system to facilitate use of collections that do exist.Failure to deal with these problems does not reflect . . .
Comparison of clinico-pathological features in hepatitis B virus-associated hepatocellular carcinoma with or without hepatitis D virus superinfection
Authors: Teh-Ia Huo, Jaw-Ching Wu, Chung-Ru Lai, Ching-Liang Lu, Wen-Yung Sheng, Shou-Dong Lee
Journal: Journal of Hepatology (1996)
ABC of Dermatology. Leg ulcers.
Authors: P K Buxton
Journal: BMJ (1987)

Although the patient will not probably die ofthis disease, yet, without great care, it may render her miserable.The disease may be very much relieved by art, and it is one ofvery common occurrence.SIR BENJAMIN BRODIE (1846) Despite the great increase in our understanding ofthe pathology ofleg ulcers, their management is still largely "art."Consequently there are numerous treatments, each with their enthusiastic advocates.There are, however, basic concepts which are helpful in management.Since about 95% ofleg ulcers are ofthe "venous" or gravitational variety these will be considered first.1542
Chest Films: Atypical Becomes Typical
Authors: UVE F. HUBLITZ
Journal: Annals of Internal Medicine (1970)

Editorial Notes1 June 1970Chest Films: Atypical Becomes TypicalUVE F. HUBLITZ, M.D., JEROME H. SHAPIRO, M.D.UVE F. HUBLITZ, M.D.Search for more papers by this author, JEROME H. SHAPIRO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-6-955 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith the increasing prevalence of chronic lung disease in the general population, related not only to smoking and possible effects of urban air pollution but also to aging of the population and the occurrence of senile emphysema, chronic lung disease is now frequent in many hospitalized patients. Pneumococcal pneumonia and congestive heart failure are two common diagnoses at admission in general hospitals. It is no surprise then that chronic lung disease frequently co-exists with these two entities. It is also no surprise, in view of the profound anatomic, physiologic, and pathologic changes in chronically diseased lungs, that the classic patterns...References1. SIMON M: The pulmonary vessels in incipient left ventricular decompensation. Circulation 24:185-190, 1961 CrossrefGoogle Scholar2. SIMON M: Pulmonary vessels; their hemodynamic evaluation using routine radiographs. Radiol Clin N Amer 1:363-376, 1963 Google Scholar3. ZISKINDGEORGEWEIL MRH: Acute localized and diffuse alveolar pneumonias. Seminars Roentgen 2:49-60, 1967 CrossrefGoogle Scholar4. HUBLITZSHAPIRO UJ: Atypical pulmonary patterns of congestive heart failure in chronic lung disease. Radiology 93:995-1006, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston City Hospital Boston University School of Medicine Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Gram-negative bacillary pneumonias 1 June 1970Volume 72, Issue 6Page: 955-956KeywordsAgingAir pollutionEmphysemaHeart failureLungsPneumoniaThorax ePublished: 1 December 2008 Issue Published: 1 June 1970 PDF downloadLoading ...
Laminar Pattern of Mineral Calcium-Phosphorus Deposits in a Human Carotid Plaque
Authors: Luigina Guasti, Franca Marino, Terenzio Congiu, Matteo Tozzi, Laura Schembri, Ramona C. Maio, Luana Castiglioni, Lorenzo Maroni, Patrizio Castelli, Daniela E. Quacci, Carlo Dell'Orbo, Anna M. Grandi, Sergio Lecchini, Marco Cosentino, Achille Venco
Journal: Circulation (2010)
Bisphosphonates do not reduce breast cancer in postmenopausal women
Authors: Aju Mathew, Adam Brufsky
Journal: Annals of Internal Medicine (2015)

Source Citation Hue TF, Cummings SR, Cauley JA, et al. Effect of bisphosphonate use on risk of postmenopausal breast cancer: results from the randomized clinical trials of alendronate and zoledronic acid. JAMA Intern Med. 2014;174:1550-7. 25111880
Improved Exercise Tolerance After Losartan and Enalapril in Heart Failure
Authors: Giorgio Vescovo, Luciano Dalla Libera, Francesco Serafini, Cristiana Leprotti, Luigi Facchin, Maurizio Volterrani, Claudio Ceconi, Giovanni Battista Ambrosio
Journal: Circulation (1998)

Background —In congestive heart failure, fatigue-resistant, oxidative, slow type I fibers are decreased in leg skeletal muscle, contributing to exercise capacity (EC) limitation. The mechanisms by which ACE inhibitors and AII antagonists improve EC is still unclear. We tested the hypothesis that improvement in EC is related to changes in skeletal muscle composition toward type I fibers. Methods and Results —Eight patients with congestive heart failure, NYHA classes I through IV, were treated for 6 months with enalapril (E) 20 mg/d, and another 8 with losartan (L) 50 mg/d. EC was assessed with maximal cardiopulmonary exercise testing at baseline and after treatment. Myosin heavy chain (MHC) composition of the gastrocnemius was studied after electrophoretic separation of slow MHC1, fast oxidative MHC2a, and fast glycolytic MHC2b isoforms from needle microbiopsies obtained at baseline and after 6 months. EC improved in both groups. Peak V̇ o 2 increased from 21.0±4.7 to 27.6±4.3 mL · kg −1 · min −1 ( P =0.011) in the L group and from 17.5±5.0 to 25.0±5.5 mL · kg −1 · min −1 ( P =0.014) in the E group. Similarly, ventilatory threshold changed from 15.0±4.0 to 19.9±4.9 mL ( P =0.049) with L and from 12.0±1.9 to 15.4±3.5 mL ( P =0.039) with E. MCH1 increased from 61.2±11.2% to 75.4±7.6% with L ( P =0.012) and from 60.6±13.1% to 80.1±10.9% ( P =0.006) with E. Similarly, MHC2a decreased from 21.20±9.5% to 12.9±4.4% ( P =0.05) with L and from 19.9±7.8% to 11.8±7.9% ( P =0.06) with E. MHC2b changed from 17.5±6.5% to 11.7±5.2% ( P =0.07) with L and from 19.5±6.4% to 8.1±4.6% ( P =0.0015) with E. There was a significant correlation between net changes in MHC1 and absolute changes in peak V̇ o 2 ( r 2 =0.29, P =0.029) and a trend to significance for MHC2a and 2b. Conclusions —Six months’ treatment with L and with E produces an improvement in EC of similar magnitude. These changes are accompanied by a reshift of MHCs of leg skeletal muscle toward the slow, more fatigue-resistant isoforms. Magnitude of MHC1 changes correlates with the net peak V̇ o 2 gain, which suggests that improved EC may be caused by favorable biochemical changes occurring in the skeletal muscle.
Determinants of Reversible Asynergy
Authors: VIDYA S. BANKA, MONTY M. BODENHEIMER, RICHARD H. HELFANT
Journal: Circulation (1974)

To determine which factors may be of value in determining whether or not asynergic zones have residual contractile ability, the responsiveness of these zones to sublingual nitroglycerin (1/150 grs) was studied angiographically in 36 patients. The responsiveness of asynergy was correlated with the presence or absence of pathologic Q waves and coronary collaterals in the corresponding zones, as well as with anatomic location. Of the 25 asynergic segments which had corresponding pathologic Q waves, 11 (44.0%) responded to nitroglycerin while 14 (56%) remained unresponsive. In contrast, 30 (83.3%) of the 36 segments which did not have associated Q waves improved while only 6 (16.4%) did not ( P &lt; 0.005). Akinetic segments with Q waves were associated with a significant decrease in responsiveness ( P &lt; 0.02) compared to hypokinetic segments. Of the 26 segments with angiographically demonstrable collaterals, 22 (84.6%) improved and only 4 (15.4%) remained unchanged ( P &lt; 0.02). In contrast, of the 35 segments without collaterals, 19 (54.3%) were responsive and 16 (45.7%) did not respond. Seven (77.8%) of the 9 akinetic segments with collaterals exhibited improvement compared to only 5 (33%) of the 15 segments without collaterals ( P &lt; 0.05). In segments with pathologic Q waves, 70% of those associated with collaterals improved compared to only 27% without collaterals ( P &lt; 0.02). Relative to anatomic location, of 29 anterior wall segments, 24 (82.8%) responded compared to only 11 (45.8%) of 24 apical segments ( P &lt; 0.005). These data indicate that the presence of coronary collaterals and absence of pathologic Q waves in the corresponding zones are associated with a higher incidence of residual contractile ability of asynergic segments. Apical asynergy responds less frequently than asynergy in other anatomic zones.
Mixed peptide–chitosan membranes to mimic the biological activities of a multifunctional laminin α1 chain LG4 module
Authors: Kentaro Hozumi, Natsumi Yamagata, Dai Otagiri, Chikara Fujimori, Yamato Kikkawa, Yuichi Kadoya, Motoyoshi Nomizu
Journal: Biomaterials (2009)
Surgical Management of Curling's Ulcer in Children
Authors: Anthony Shaw
Journal: JAMA (1966)

SURGICAL correction of complications arising from Curling's ulcer in children has rarely been reported. We have been able to find only six acceptable reports of surgery in such cases. The earliest was Regenbrecht's<sup>1</sup>description in 1959 of closure of a perforated gastric ulcer 18 days following extensive body burns. The child died of bronchopneumonia on the 18th postoperative day. In 1960, Lasserre et al<sup>2</sup>reported a case of a 6 1/2-year-old girl who underwent partial duodenal resection and gastrojejunostomy for a bleeding Curling's ulcer located in the duodenum. The child lived and is believed to be the first survival documented in the literature. The second survival was reported by Leix and Greaney in 1963.<sup>3</sup>Their patient was a 2-year-old girl who underwent surgery for hemorrhage and perforation. The third survival was presented by Abramson<sup>4</sup>in 1964. He described a 10-year-old boy with extensive burns who underwent
<i>Pfiesteria</i>and Learning Problems
Authors: Joan Stephenson
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Danforths’s Obstetrics and Gynecology
Authors: Ronald T. Burkman
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fluorodensimetry. A method for analyzing regional ventilation and diaphragm function
Authors: R. B. George
Journal: JAMA (1971)

Fluorodensimetry is a method for amplifying and recording changes in density which occur over the thorax during fluoroscopy, and thereby analyzing regional ventilation and diaphragm movement. This method was used to evaluate 13 normal subjects and over 300 patients with various ventilatory disturbances. Patients with chronic obstructive pulmonary disease (COPD) tended to shift ventilation toward upper lung zones, and diaphragm function was markedly altered in the presence of air trapping. Obese individuals without complicating COPD were able to increase diaphragm movement during voluntary deep breathing and thus shift ventilation toward the lower zones; obese patients with COPD did not. Localized air trapping in poorly communicating bullae or distal to obstructed major bronchi resulted in characteristic changes of regional ventilation.
Rotary Clubs Offer Help in Preschool Immunization
Authors: Andrew A. Skolnick
Journal: JAMA (1993)

WHILE in the middle of their efforts to help eradicate polio from the world by the year 2000, US Rotary service club representatives say they are ready to pitch in and help the US government reach its goal of immunizing at least 90% of all preschoolers against vaccine-preventable diseases by 1996.
Cryptococcal tonsillitis in a patient with chronic lymphocytic leukemia: An unusual manifestation of cryptococcal disease
Authors: Joyce Korvick, Victor L. Yu
Journal: American Journal of Hematology (1987)

Abstract We present a case of chronic tonsillitis in a patient with chronic lymphocytic leukemia. Despite empiric radiation and antibiotic therapy, the patient's sore throat and tonsillar enlargement persisted. Excisional biopsy of the involved tonsil revealed the presence of Cryptococcus neoformans . Blood cultures also yielded cryptococcus. Specific antifungal therapy resulted in cure. To knowledge our this is the first case report of cryptococcal infection of the tonsil. This case illustrates the pitfalls of empiric therapy in an immunosuppressed host.
Medical and dental training and staffing in a region--the long and short of it.
Authors: J Parkhouse, J M O'Brien
Journal: BMJ (1984)

Medical manpower planning is hardly a science.It certainly is not exact.The agreement between the Joint Consultants Committee and the health departments in 1971 dealt with ratios of junior to senior hospital staff and said nothing about actual numbers.The Progress Reports concerned the careers of doctors, rather than the needs of patients.iNational medical staff tables from the Department of Health and Social Security show numbers of doctors employed on a given date, not numbers of posts available or how many people are required to do the work and to train for the future.There are well known regional dif- ferences in medical staffing, which have altered little and bear no measured relation to indices of health, sickness, and death.The manpower planning plot comprises an annual dialogue between those who are re- sponsible, centrally, for balancing national needs with the availability of potential new consultants, and those responsible at regional level for trying to achieve perceived priorities.The subplot consists of a further dialogue between regions, always conscious of resource constraints, and districts all seeking to fulfil, in implicit competition, their individual operational plans.The whole play is subject to sporadic overriding views of the treasury.All these factors effectively shield the Central Manpower Committee from knowing the real demand for additional medical staff.Nobody knows whether lack of consultant expansion is mainly due to poverty, professional in- transigence, or incompetent planning, but strong views are heard.
US health spending surges to 17% of GDP
Authors: B. Roehr
Journal: BMJ (2010)

Spending on health care in the United States rose to $2.5 trillion (£1.6 trillion; €1.8 trillion) in 2009, experts at the government’s Center for Medicare and Medicaid Services have estimated.

That is a rise of 5.7% over the amount spent in 2008. Spending on health care in the US now constitutes 17.3% of the gross domestic product (GDP), up from 16.2% in 2008.

It is the largest percentage increase in health spending in the five decades that records have been kept. The analysis attributes much of the increase to the economic recession that struck the US in 2009, resulting …
Impact of viral eradication on mortality related to hepatitis C: A modeling approach in France
Authors: Sylvie Deuffic-Burban, Pierre Deltenre, Alexandre Louvet, Valérie Canva, Sebastien Dharancy, Antoine Hollebecque, Jeanne Boitard, Jean Henrion, Yazdan Yazdanpanah, Philippe Mathurin
Journal: Journal of Hepatology (2008)
Inter-Relations between Adrenocortical Functions and Infectious Illness
Authors: William R. Beisel, Morton I. Rapoport
Journal: New England Journal of Medicine (1969)

Adrenal-Hormone Effects during InfectionMany specific actions have been described for glucocorticoids, but none of these adequately explain how a physiologic concentration of the hormones protect the infected host. The complexity of this problem is due largely to the capacity of adrenal hormones to influence virtually every organ system, defense mechanism and biochemical pathway that might participate in the host response to infectious illness.1,5 The majority of experimental studies conducted in vivo with exogenous steroids leave unanswered many questions concerning the role of the host's own adrenal response. For example, the interaction of corticosteroids with specific antimicrobial systems of host . . .
Chronic rhinosinusitis and nasal polyps: the role of generic and specific questionnaires on assessing its impact on patient’s quality of life
Authors: I. Alobid, M. Bernal‐Sprekelsen, J. Mullol
Journal: Allergy (2008)

Chronic rhinosinusitis (CRS) including nasal polyps is a chronic inflammatory disease of the nasal and paranasal sinus mucosa that, despite differing hypotheses of its cause, remains poorly understood. Primary symptoms are nasal blockage, loss of smell, rhinorrhea, and facial pain or pressure. Chronic rhinosinusitis causes significant physical symptoms, has a negative impact on quality of life (QoL), and can substantially impair daily functioning. A global evaluation of patients must include, together with nasal symptoms, nasal endoscopy, and CT scan, the measurement of QoL. To assess QoL in CRS, specific and generic questionnaires may be used. Chronic rhinosinusitis has a considerable impact on a patient's QoL but comorbidities, such as asthma and atopy, have an accumulative negative effect. Both medical and surgical treatments lead to a similar improvement on the QoL of CRS and nasal polyp patients.
Functionally conformed free class I heavy chains exist on the surface of beta 2 microglobulin negative cells.
Authors: M Bix, D Raulet
Journal: The Journal of Experimental Medicine (1992)

Cytotoxic T lymphocytes (CTL) can recognize antigenic peptides bound in a groove formed by the alpha 1 and alpha 2 domains of the heterodimeric major histocompatibility complex class I molecule. Proper assembly, transport, and stability of functional class I molecules is thought to require beta 2 microglobulin (beta 2m), the light chain of the class I heterodimer. We show here that the requirement for beta 2m is not absolute. beta 2m- cells can be stained by the Db alpha 1 domain-specific B22-249.1 monoclonal antibody, which detects a conformation-dependent epitope. Furthermore, beta 2m- Con A blast target cells can be lysed by alloreactive CTL, even in serum-free conditions. Contrary to previous reports, the expression of low levels of conformed Db heavy (H) chains is a property to both normal and transformed beta 2m- cells. Finally, we present evidence that a subset of properly conformed H chains, free of beta 2m, may have almost equal representation on beta 2m+ and beta 2m- cells.
Smac mimetics: implications for enhancement of targeted therapies in leukemia
Authors: Ellen Weisberg, Arghya Ray, Rosemary Barrett, Erik Nelson, Amanda Christie, Dale Porter, Christopher Straub, Leigh Zawel, John F. Daley, Suzan Lazo-Kallanian, Richard Stone, Ilene Galinsky, David Frank, Andrew L. Kung, James D. Griffin
Journal: Leukemia (2010)