tbuckley/cabot-search huggingface dataset:
Uptake of Tc-99m MDP in Soft Tissue Calcific Deposits Due to the Tumor Lysis Syndrome
Authors: LORRAINE M. FIG, BRAHM SHAPIRO, BARRY L. SHULKIN
Journal: Clinical Nuclear Medicine (1988)

While uptake of bone scanning agents in soft tissue abnormalities is common and has multiple causes, uptake of bone scanning agents in calcium-phosphate deposits involved in the tumor lysis syndrome has not previously been reported. Further studies will be necessary to determine the incidence of soft tissue accumulation of Tc-99m MDP following massive phosphate release.
The modulation of endothelial cell morphology, function, and survival using anisotropic nanofibrillar collagen scaffolds
Authors: Ngan F. Huang, Janet Okogbaa, Jerry C. Lee, Arshi Jha, Tatiana S. Zaitseva, Michael V. Paukshto, John S. Sun, Niraj Punjya, Gerald G. Fuller, John P. Cooke
Journal: Biomaterials (2013)
Two Views Toward the Hard-of-Hearing
Authors: Roger Bibace
Journal: JAMA (1980)

To the Editor.—  An elderly man began having hearing problems, and at 82 years, after consulting with top ear, nose, and throat specialists and an audiologist at a university hospital in a large city, purchased twin hearing aids at the considerable price of $400 each. But that was not the end of the problem. At their best, after repeated adjustments, the hearing aids were useful to this man in a one-to-one conversation, but in a family group he most often resigned himself to isolation—frustrated by trying to hear while intrusive background noises drowned out the meaningful conversation.  This summer there was a breakthrough of sorts. I wondered if a relatively simple idea—using ordinary hi-fidelity equipment for communication—might not pay off. Most hi-fi systems allow the use of headphones, and, with a simple adapter, a microphone. As one person talks into the microphone, the other person wears the headphones and adjusts
Localized heat urticaria associated with a decrease in serum complement factor B (C3 proactivator)
Authors: E. A. JOHANSSON, T. REUNALA, S. KOSKIMIES, A. LAGERSTEDT, K. KAUPPINEN, K. TIMONEN
Journal: British Journal of Dermatology (1984)

A case of localized heat urticaria is reported in a 51-year-old woman who within a few minutes of contact with warm water developed erythema and swelling sharply localized to the heated area. After a hot bath urticarial lesions appeared over large areas of her body, accompanied by a feeling of weakness, but no other systemic symptoms. After challenge with heat by immersing her left arm in water heated to 42°C, a rapid decrease of her serum complement level of factor B was demonstrated, suggesting that activation of an alternative complement pathway plays a role in this form of urticaria. Biopsies for immunofluorescent study of complement and immunoglobulins were negative at 30 and 180 min after heat challenge. The dermal fibres and endothelial cells of dermal vessels were capable, in vitro, of complement binding before and after exposure to heat.
Double-blind Trial of Carbenoxolone Sodium Capsules in Duodenal Ulcer Therapy, Based on Endoscopic Diagnosis and Follow-up
Authors: P. Brown, P. R. Salmon, None Thien-Htut, A. E. Read
Journal: BMJ (1972)

A high-dose double-blind trial of carbenoxolone sodium capsules (Duogastrone) in the treatment of duodenal ulceration was combined with endoscopic diagnosis and follow-up. Thirty-one ambulant patients with an endoscopically visible duodenal ulcer were allocated at random to a 12-week course of treatment with either carbenoxolone sodium 300 mg daily or a placebo. Symptomatic and endoscopic follow-up was performed at 2-4 weeks, 6-8 weeks, and 12-16 weeks. Carbenoxolone was shown to increase the rate of healing of duodenal ulcers in the early stages of treatment, but by 12 weeks there was no difference between the two groups. There was no significant difference in symptomatic improvement between the two groups at any stage of treatment. Side effects, especially hypokalaemia, were prominent in the patients treated with carbenoxolone. There was a poor relation between endoscopic and symptomatic improvement in patients on either form of treatment.
Hypocholesterolaemia and non-cardiovascular disease: metabolic studies on subjects with low plasma cholesterol concentrations.
Authors: C B Marenah, B Lewis, D Hassall, A La Ville, C Cortese, W D Mitchell, K R Bruckdorfer, B Slavin, N E Miller, P R Turner, E Heduan
Journal: BMJ (1983)

Some epidemiological studies have suggested an inverse relation between serum cholesterol concentration and mortality from cancer. Two hypotheses that might explain such a relation were investigated. To assay potentially deleterious effects of hypocholesterolaemia on cell membranes the lipid content and fluidity of blood mononuclear cells were measured in healthy male volunteers with a wide range of serum cholesterol concentration (3.2-10.0 mmol/l (124-387 mg/100 ml)). Fluidity, unesterified cholesterol content, and the ratio of cholesterol to phospholipid were unrelated to serum cholesterol and to low density lipoprotein cholesterol concentrations. Similar measurements were made on fibroblasts and mononuclear cells incubated with a range of concentrations of low density lipoprotein; fluidity was altered only at extremely low concentrations, suggesting that changes in cell membranes are unlikely to occur at serum cholesterol concentrations attainable by dietary or drug treatment of hyperlipidaemia. In the same population direct relations were confirmed between low density lipoprotein concentration and plasma concentrations of retinol and beta carotene. This is compatible with the suggestion that an association between low cholesterol concentration and cancer may be secondary to a relation between low retinoid concentrations and cancer.
Trusts raid public health funds to cover NHS debts
Authors: Claire Laurent
Journal: BMJ (2007)

NHS trusts across England used funds earmarked for public health to avoid financial crisis instead of tackling key issues such as obesity, alcohol misuse, and sexual health, a survey of public health directors has found.

Responses from 103 of England's 152 primary care trusts to the survey by the Association of Public Health Directors showed that two thirds of the 2006-7 public health allocation was spent on servicing debts. Less than a 10th of trusts used the full allocation for its intended purpose.

Following on from the 2004 government white paper Choosing Health: …
Globin-Zinc-Insulin: Some Experiments
Authors: R. D. Lawrence
Journal: BMJ (1943)

GLOBIN-ZINC-INSULINMDITAL JOURNA 103 circulation had recovered completely after two hours-i.e., four hours after the blockage-and full use of the legs was regained.His cardiac condition did not improve and he developed a subacute bacterial endocarditis, but he was lost sight of at the time of the forced hospital evacuation in Sept., 1939.Case 5.-Woman aged 36, admitted April 12, 1939, with auricular fibrillation and slight cardiac failure.She was given small doses of digitalis, and on May 5 developed a right femoral occlusion with the typical signs and slight pain.She was operated on within four hours under spinal anaesthesia, and an embolus together with 8 in. of thrombus was removed.The circulation recovered perfectly and pulsation of the posterior tibial artery at the ankle could be felt after a few hours.She left hospital, and although still fibrillating was doing most of her housework one year later.
Functional characterisation of decoy receptor 3 in Crohn's disease
Authors: B Funke, F Autschbach, S Kim, F Lasitschka, U Strauch, G Rogler, G Gdynia, L Li, N Gretz, S Macher-Goeppinger, B Sido, P Schirmacher, S C Meuer, W Roth
Journal: Gut (2008)

<h3>Aims:</h3> Both epithelial barrier dysfunction and apoptosis resistance of immune cells contribute to the pathogenesis of Crohn's disease. The soluble decoy receptor 3 (DcR3) acts in an anti-apoptotic manner by neutralising the death ligand CD95L. Here, we investigated the possible involvement of DcR3 in Crohn's disease. <h3>Methods:</h3> The epithelial fraction of human small intestinal mucosa samples was obtained by laser microdissection. Expression of DcR3 was examined by global gene expression profiling, quantitative reverse transcription polymerase chain reaction, immunoblot analysis, and immunohistochemistry. DcR3 concentrations in the serum of patients with Crohn's disease were measured by enzyme-linked immunosorbent assay. Apoptosis assays were performed to study the effects of DcR3 in intestinal epithelial cells and lamina propria T cells. <h3>Results:</h3> DcR3 is over-expressed in the epithelial layer of ileum specimens in patients with Crohn's disease, both at actively inflamed and non-active sites. DcR3 serum levels are significantly elevated in patients with active and non-active Crohn's disease as compared to healthy controls. The expression of DcR3 in intestinal epithelial cells is induced by tumour necrosis factor α. Increased DcR3 expression is associated with activation of nuclear factor kappa B (NF-κB) and results in protection of intestinal epithelial cells and lamina propria T cells from CD95L-induced apoptosis. <h3>Conclusions:</h3> DcR3 may promote inflammation in Crohn's disease by inhibiting CD95L-induced apoptosis of epithelial and immune cells as well as by inducing NF-κB activation.
Teaching students in the community
Authors: D F Bird
Journal: BMJ (1994)

EDITOR; - Mary Seabrook and colleagues highlight community health professionals' enthusiasm for teaching medical students.1 But is enthusiasm enough? The authors point out that funds need to be found to support community based teaching.

Last year I looked into the teaching carried out by general practitioners in the South Western region attached to the department of general practice of Bristol Medical School. I asked the tutors what they did with students then and what they would be prepared to do in the future. Altogether 126 of 150 …
Deletion of Kir6.2 worsens diastolic dysfunction in the stunned myocardium
Authors: Richard J. Gumina, Christopher E. Kurtz, Peter Bast, Denice Hodgson, Fergus O'Coclain, Takashi Miki, Susumu Seino, Andre Terzic
Journal: Journal of the American College of Cardiology (2003)
An Evaluation of Oral Cholecystography
Authors: Harold D. Rosenbaum
Journal: JAMA (1974)

RADIOLOGICAL studies permit evaluation of the gallbladder and its function with greater precision than is possible to achieve when examining any other abdominal organ. Oral cholecystography with iopanoic acid (Telepaque) is the examination most frequently employed for this purpose. The entire medical profession accords a remarkable level of confidence to cholecystographic findings. Thus, it appears appropriate to review the basic considerations involved in this examination as well as the significance of the findings that result from such studies. <h3>The Examination</h3><h3>Opaque Medium.—</h3> Iopanoic acid is the opacifying agent used by almost all radiologists, since it has been shown to be less toxic and generally more useful than its predecessors. Study continues on other orally given agents, although none as yet have shown sufficient additional advantages to supplant iopanoic acid. <h3>Dosage.—</h3> An initial dose of 3 gm is generally accepted as adequate. There is no justification for huge doses. On the
End-of-Life Medications Draw More Attention, Greater Scrutiny
Authors: Judith Graham
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Pacemaker Syndrome
Authors: KALMAN AUSUBEL
Journal: Annals of Internal Medicine (1985)

The pacemaker syndrome is a complex of clinical signs and symptoms related to the adverse hemodynamic and electrophysiologic consequences of ventricular pacing in the absence of other causes. Neurologic symptoms or those suggesting low cardiac output or congestive heart failure, temporally related to the onset of ventricular pacing, are indicative of the pacemaker syndrome. The evolution of a clinically recognized syndrome, an analysis of possible mechanisms and clinical manifestations, and diagnostic approaches and their implications for management are discussed.
Emergency management of head injuries.
Authors: J. M. Potter
Journal: BMJ (1965)

Unfortunately nothing can be done to reverse damage already sustained by an injured brain, but if the injury has not been an essentially lethal one emergency attention to ensure respira tory efficiency, to control severe haemorrhage, and to maintain an adequate circulation will prevent further brain damage from hypoxia. Attention to the head itself is not, therefore, usually the prim? consideration when the injury has been a severe one.
Managers put technology before patients, say MPs
Authors: J Warden
Journal: BMJ (1994)

The Commons public accounts committee has expressed “grave concern” that a computer project in Wessex Regional Health Authority wasted at least £20m that should have been spent on health care. There was more excitement and interest in building up new technology than in providing services for patients, the report says.

Last month the same committee reported in similar terms on the waste of £10m on a management venture in the West Midlands region. The criticisms coincide with remarks …
Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice
Authors: Bruce T. Lamb, Sangram S. Sisodia, Ann M. Lawler, Hilda H. Slunt, Cheryl A. Kitt, William G. Kearns, Peter L. Pearson, Donald L. Price, John D. Gearhart
Journal: Nature Genetics (1993)
Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2
Authors: Anne-Marie Preaux, Marie-Pia D’Ortho, Marie-Pierre Bralet, Yannick Laperche, Philippe Mavier
Journal: Hepatology (2002)

Liver fibrosis is potentially reversible after removal of the injurious agent. Fibrosis resolution is characterized by apoptosis of hepatic myofibroblasts and degradation of extracellular matrix components. Matrix metalloproteinase-2 (MMP-2) is involved in matrix remodeling. In the liver, it is synthesized by myofibroblasts, secreted as a proenzyme, and activated by membrane type-MMPs (MT-MMP) such as MT1-MMP. The goal of this work was to determine whether apoptosis induction in human hepatic myofibroblasts modulates the gene expression of MMP-2 and/or its activation by MT1-MMP. Induction of apoptosis by cytochalasin D or C(2)-ceramide did not modulate MMP-2 mRNA expression. In contrast, apoptosis was associated with marked activation of pro-MMP-2, as shown by gelatin zymography, which revealed the presence of the 59-kd active form, whereas untreated cells only expressed the 66-kd proform. SB-203580, a specific inhibitor of p38 (MAPK), selectively abrogated both C(2)-ceramide-induced apoptosis and pro-MMP-2 activation. Apoptosis-induced pro-MMP-2 activation was inhibited by the tissue inhibitors of metalloproteinases (TIMP)-2 but not by TIMP-1, implying involvement of an MT-MMP-mediated process. Induction of apoptosis by cytochalasin D and C(2)-ceramide upregulated MT1-MMP protein expression and MT1-MMP mRNA expression. In conclusion, apoptosis of hepatic myofibroblasts induces pro-MMP-2 activation through increased MT1-MMP expression. HEPATOLOGY 2002;36:615-622.)
A RECORD OF THE DISEASES OF FIVE HUNDRED AND SIXTY CONVICTS UNDERGOING CELL CONFINEMENT.
Authors: M. V. BALL
Journal: JAMA (1898)

In this paper I have attempted to catalogue the more serious ailments affecting a number of convicts, whom I have had the opportunity to examine on admission and to have under observation for a period of from one to three years. I have excluded those already confined when I entered on my duties and all those who were admitted in the last year of my service, whom I had not sufficient time to observe. In order to show the effect of confinement, if any, I have divided the whole number into two groups. In Group 1 are convicts under observation for an average term of eighteen months. In Group. 2, convicts under observation for an average term of two and one-half years. In the latter group will be found many more of the malefactors who had committed crimes against the person or who belonged to the habitual offenders. There were
Distribution of pulmonary capillary transit times.
Authors: R A Klocke, H J Schünemann, B J Grant
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The length of time that blood remains in the pulmonary capillary is an important variable in gas exchange. We have investigated the distribution of capillary transit times in isolated rabbit lungs perfused with a bicarbonate-free buffer. The time course of gas exchange was monitored by enclosing the lungs in a plethysmograph. A bolus of buffer containing dissolved acetylene was injected into the perfusion system. Exchange of this inert gas occurred as soon as the bolus reached the capillary bed, thereby describing the input function into the bed. A separate bolus injection of bicarbonate solution resulted in production and excretion of CO2 as long as the bolus remained in the capillary bed. The rate of CO2 production was adjusted by partial inhibition of endothelial carbonic anhydrase. The distribution of capillary transit times was computed from a model of CO2 production in the capillary bed and the observed rates and volumes of acetylene and carbon dioxide excretion. The recovered distributions indicate that there is a fairly wide distribution of capillary transit times (relative dispersion, 0.45) around the mean value of 1.71 s (+/- 0.53 [SD]). Only 10% of capillary transit times are less than one half of mean transit time. It is likely that gas exchange reaches equilibrium in the capillary bed except possibly during strenuous exercise or exposure to high altitude or in disease.
THE ROUTINE USE OF SPINAL ANAESTHESIA: A STUDY OF FIVE HUNDRED CONSECUTIVE CASES
Authors: O. Richards
Journal: BMJ (1911)

j4ANAESTHKSIA.r 3, rgIr CASE 65.-Gastrostrny: Carcinomna of Oesopiagits.W. D., male, aged 59.Patient, although unable to swallow solids, and very little fluid, was still in fair -condition, but suffering a good deal of pain.Injection 6 cg. in dorsi-lumbar interspace.Owing to an error in arranging the table, the an- algesia ran rather high and fairly rapidly, reaching the clavicles in three minutes.Patient became rather pallid, but his respiration remained good throughout; he complained of inability to cough, a sign I have noted in a few other cases of very high analgesia, where the intercostals have been affected.The pulse was also feeble for some minutes, but at no time did his condition cause anxiety.Analgesia at this time found to reach third cervical; diaphragmatic respiration good.A Senii's gastrostomy was easily and quite painlessly performed, retching only occurring on two occasions, when a mouthful of bile was ejected.Operation lasted twenty-five minutes, at the end of which a little oxygen was given for the patienit's comfort, not because he was cyanosed.Fifteen minutes after returning to bed, analgesia had fallen to the fifth dorsal.No after-effects, except pyrexia.Pulse 87, temperature 99.80.Convalescence normal.N.B.-This case represents the hlighest analgesia I have ever obtained, with the exception of those cases done by Jonnesco's method.5It was unintentional, nunlecessary, and should not have occurred.It, however, again serves to prove the immunity of the heart to the influeilce of stovaine, and supports the statement I have made elsewlhere that the success of Jonnesco's method is not necessarily due to the presence of strychnine.
Relationship between serum sex hormones and the glucose-insulin-lipid defect in men with obesity
Authors: Gerald B. Phillips
Journal: Metabolism (1993)

It has been hypothesized that an alteration in the sex hormone milieu may underlie coronary heart disease (CHD) and its risk factors. Leading to this hypothesis and important to it was the observation that serum testosterone level correlated negatively and the estradiol to testosterone ratio () correlated positively with serum insulin and glucose levels in non-obese men. As a test of the validity of this observation, the present study was conducted to investigate these correlations in men with obesity. Obesity in men is associated with hyperestrogenemia, hypotestosteronemia, hyperinsulinemia, hyperglycemia, and CHD. To determine whether the relationships between sex hormone levels and insulin and glucose levels found in non-obese men also occur in obese men independent of obesity, fasting levels of these substances, as well as free testosterone (FT) and sex-hormone-binding globulin (SHBG), were measured in 55 obese men aged 21 to 70. Correlation coefficients of sex hormones with other risk factors for CHD, ie, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), blood pressure, and waist to hip circumference ratio (), were also calculated. As found previously, testosterone level correlated negatively with insulin (r = −.31, P = .01) and glucose (r = −.23, P < .05) levels and the insulin to glucose ratio (), and correlated positively with insulin (r = .41, P = .001) and glucose (r = .24, P < .05) levels and (r = .37, P < .005). The above correlations were controlled for body mass index (BMI) and age. Many other correlations were observed. These findings support the hypothesis that an elevation of , or some closely related hormonal alteration, in men underlies the glucose-insulin-lipid defect associated with CHD.