A Mechanism of Cell Destruction in Individuals Sensitized to Foreign Antigens and Its Implications in Auto-immunity
Authors: N. RAPHAEL SHULMAN
Journal: Annals of Internal Medicine (1964)

NIH Conference1 March 1964A Mechanism of Cell Destruction in Individuals Sensitized to Foreign Antigens and Its Implications in Auto-immunityCombined Clinical Staff Conference at the National Institutes of HealthN. RAPHAEL SHULMAN, M.D.N. RAPHAEL SHULMAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-3-506 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDrug purpura (1-6), drug hemolytic anemia (7-9), and drug leukopenia (10-12) are now classic examples of diseases in which sensitization to a foreign antigen causes destruction of the sensitized individual's own cells. In these disorders, it is known (1, 2) that the drug somehow elicits antibody, and that the presence of drug is required for antibody to attach to the specific cells that are destroyed. However, the question ofhowantibodies against drug antigens become attached to autologous cells, the related questions of how a drug stimulates antibody, and why a particular cell type is affected have been matters of...References1. ACKROYD JF: The pathogenesis of thrombocytopenic purpura due to hypersensitivity to sedormid. Clin. Sci. 7: 249, 1949. MedlineGoogle Scholar2. ACKROYD JF: Role of complement in sedormid purpura. Clin. Sci. 10: 185, 1951. MedlineGoogle Scholar3. BOLTONDAMESHEK FGW: Thrombocytopenic purpura due to quinidine. Blood 11: 527, 1956. CrossrefMedlineGoogle Scholar4. SHULMAN NR: Immunoreactions involving platelets. I. A steric and kinetic model for formation of a complex from a human antibody, quinidine as a haptene, and platelets; and for fixation of complement by the complex. J. Exp. Med. 107: 665, 1958. CrossrefMedlineGoogle Scholar5. SHULMAN NR: Immunoreactions involving platelets. IV. 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Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandThis is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Maryland, by the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, United States Public Health Service, Department of Health, Education, and Welfare.Part of this material was presented at the April 30, 1963 meeting of the Association of American Physicians, and appears in the Trans. Ass. Amer. Physicians 76: 72, 1963.Requests for reprints should be addressed to N. Raphael Shulman, M.D., National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014. 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PHYSIOLOGIC, SEROLOGIC AND ISOTOPIC STUDIESSplenectomy 1 March 1964Volume 60, Issue 3Page: 506-521KeywordsAntigensArthritisDrugsGeneticsHemolytic anemiaMedical servicesMetabolic disordersNeutrophilsPrevention, policy, and public health Issue Published: 1 March 1964 PDF DownloadLoading ...