tbuckley/cabot-search huggingface dataset:
Transmission of Retroviruses by Transfusion of Screened Blood in Patients Undergoing Cardiac Surgery
Authors: Noah D. Cohen, Alvaro Muñoz, Bruce A. Reitz, Paul K. Ness, O. Howard Frazier, David H. Yawn, Helen Lee, William Blattner, James G. Donahue, Kenrad E. Nelson, B. Frank Polk
Journal: New England Journal of Medicine (1989)

We determined the rates of seroconversion to human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus Type I (HTLV-I) in a cohort of patients receiving transfusions of blood components screened for antibody to HIV-1. Preoperative and postoperative serum samples were collected from 4163 adults undergoing cardiac surgery who received 36,282 transfusions of blood components. The postoperative samples from all patients were tested for serologic evidence of HIV-1 infection, and those that were positive were compared with the corresponding preoperative samples. One case of HIV-1 transmission by transfusion of screened blood components was identified; two preexisting HIV-1 infections were found. Samples from 2749 patients were tested similarly for serologic evidence of HTLV-I infection; these patients received 20,963 units of blood components. Five new cases and two preexisting cases of HTLV-I infection were detected. The observed risk of HIV-1 transmission by transfusion was 0.003 percent per unit; the risk of HTLV-I transmission was 0.024 percent per unit. We conclude that there is a very small risk of HTLV-I infection from transfused blood products that have been screened for antibodies to HIV-1, but that it is nearly 10-fold higher than the risk of HIV-1 infection. (N Engl J Med 1989;320:1172–6.)
Influenza Immunization for Children
Authors: Elizabeth D. Barnett
Journal: New England Journal of Medicine (1998)

Influenza continues to be a major cause of morbidity and mortality, despite intensive efforts to vaccinate persons at high risk. In the United States, the annual rates of influenza range from 10 to 20 percent in the general population and may reach as high as 40 percent in children. This past winter, a strain of influenzavirus previously believed to cause disease only in birds was responsible for illness and several deaths in Hong Kong and led to a massive public health initiative.1 In North America, a strain of influenzavirus that was not included in this year's vaccine circulated widely, reducing . . .
PHYSICIANS, DENTISTS AND FOCAL INFECTION IN THE DAKOTAS
Authors: CHARLES FRANK MORSMAN
Journal: JAMA (1924)

For some time it has been evident that there is a great divergence of views, among physicians and among dentists, in the diagnosis and treatment of infections of the jaws. To assist in clarifying this regrettable situation to some extent, I have sent a questionnaire to 1,042 physicians and 541 dentists, being all the men and women who represent the two professions in North Dakota and South Dakota. With each copy of the questionnaire was enclosed a courteous letter, stating the reason for this study, together with a stamped, addressed envelop for reply. I received 219 replies from the dentists and 281 replies from the physicians. <h3>QUESTIONS</h3> What is your opinion as to the extraction of a tooth that shows definite periapical or pericemental destruction? Do you believe that a tooth, at the apex of which an abscess exists, should be extracted at once, or do you advise treatment? Do
A Heart Function Test with Continuous Registration of Oxygen Consumption and Carbon Dioxide Production
Authors: J. JONGBLOED, C. L. C. VAN NIEUWENHUIZEN, H. VAN GOOR
Journal: Circulation (1957)

The authors present a test of myocardial function based on the continuous registration of pulmonary exchange of oxygen and carbon dioxide during rest and a standard amount of work. The authors believe that the test is simple enough for wide clinical application. The "functiocardiogram" is of considerable physiologic and clinical interest. The normal values of the test are defined and afew examples of abnormal tests are discussed.
Hidden Treasure: The National Library of Medicine
Authors: Tony Miksanek
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Developing an immunotherapy strategy for the effective treatment of patients with squamous cell carcinoma of the head and neck
Authors: Tarsem Moudgil, R Bryan Bell, Rom Leidner, Rieneke Van de Ven, Zipei Feng, Michael Affentoulis, Christopher Paustian, Christopher Dubay, Traci L Hilton, Walter J Urba, Hong-Ming Hu, Carlo B Bifulco, Bernard A Fox
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Squamous cell carcinoma of the head and neck (HNSCC) arises in the oral cavity, oropharynx, larynx or hypopharynx, and is the 6th leading cause of cancer by incidence worldwide. Approximately 600,000 cases arise each year, and only 40-50% of these patients will survive for 5 years
Polymorphonuclear Leucocyte Chemotaxis in Patients with Bacterial Infections
Authors: A. G. Mowat, J. Baum
Journal: BMJ (1971)

A new in vitro method of measuring the chemotaxis of polymorphonuclear leucocytes from peripheral blood has been used to calculate a chemotactic index. The mean chemotactic index in 15 patients with bacterial infection (434) was significantly less (P &lt;0·0005) than in 15 normal controls (553) matched for age and sex. The reduction in chemotaxis could be correlated with the duration of the infection, with the greatest impairment being found in those patients with the shortest duration of infection. In five patients studied before and after appropriate therapy the chemotactic index returned to normal values with clearing of the infection. It is suggested that the impairment in chemotaxis may be due to prior phagocytosis of antibody-antigen complexes by the polymorphonuclear leucocytes.
Asymmetric Septal Hypertrophy in Father, Mother, and Children
Authors: PAMELA A. CHEVERS, PETER F. COHN
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 January 1980Asymmetric Septal Hypertrophy in Father, Mother, and ChildrenPAMELA A. CHEVERS, B.A., PETER F. COHN, M.D.PAMELA A. CHEVERS, B.A.Search for more papers by this author, PETER F. COHN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-1-133_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We describe here a family (husband, wife, and children) with asymmetric septal hypertrophy. To our knowledge, this is the first report of an entire family with this disorder.A 54-year-old European-born woman was admitted to the hospital with acute onset of headache and right homonymous hemianopsia. The patient's family history was negative for sudden death or congenital heart disease. She had developed symptoms of peripheral edema and fatigue during three pregnancies, and her final pregnancy (at age 33 years) was terminated prematurely because the symptoms were so severe. She subsequently underwent cardiac catheterization (in Europe) and was...References1. MARONROBERTSEDWARDSMCALLISTERFOLEYEPSTEIN BWJHDS. Sudden death in patients with hypertrophic cardiomyopathy: characterization of 26 patients without functional limitation. Am J Cardiol. 1978;41:803-10. CrossrefMedlineGoogle Scholar2. SAVAGESEIDESMARONMYERSEPSTEIN DSBDS. Prevalence of arrhythmias during 24-hour electrocardiographic monitoring and exercise testing in patients with obstructive and nonobstructive hypertrophic cardiomyopathy. Circulation. 1979;59:866-75. CrossrefMedlineGoogle Scholar3. BRENTABURANOFISHER LAD. Familial muscular subaortic stenosis: an unrecognized form of "idiopathic heart disease," with clinical and autopsy observations. Circulation. 1960;21:167-80. CrossrefMedlineGoogle Scholar4. CLARKHENRYEPSTEIN CWS. Familial prevalence and genetic transmission of idiopathic hypertrophic subaortic stenosis. N Engl J Med. 1973;289:709-14. CrossrefMedlineGoogle Scholar5. MARONLIPSONROBERTSSAVAGEEPSTEIN BLWDS. "Malignant" hypertrophic cardiomyopathy: identification of a subgroup of families with unusually frequent premature death. Am J Cardiol. 1978;41:1133-40. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Peter Bent Brigham Hospital Harvard Medical School Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1980Volume 92, Issue 1Page: 133-133KeywordsCatheterizationChildrenCongenital heart diseaseEdemaFatigueHeadachesPregnancy Issue Published: 1 January 1980 PDF DownloadLoading ...
Development of a post-mortem procedure to reduce the uncertainty regarding causes of death in developing countries
Authors: Quique Bassat, Jaume Ordi, Jordi Vila, Mamudo R Ismail, Carla Carrilho, Marcus Lacerda, Khátia Munguambe, Frank Odhiambo, Bertrand Lell, Samba Sow, Zulfiqar A Bhutta, N Regina Rabinovich, Pedro L Alonso, Clara Menéndez
Journal: The Lancet Global Health (2013)
259. Uterine Fibroids Gene Therapy: Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Treatment Inhibits Growth of Human and Rat Leiomyoma Cells
Authors: Ayman Al-Hendy, Marwa Kamel, Gregory Christman, Salama A. Salama
Journal: Molecular Therapy (2005)

Introduction: Adenovirus-mediated herpes simplex virus thymidine kinase gene transfer in combination with ganciclovir (Ad-TK/GCV) is one of the major gene therapy strategies to eradicate tumor cells. Leiomyoma is a benign uterine tumor that affects high percentage of women in their reproductive age. Unfortunately, there is no effective and safe medical treatment available. Leiomyom is developed as discrete well-defined tumor, easily accessible with imaging techniques which makes it a good candidate for localized gene therapy approaches.
The Meaning of "Significant Bacteriuria"
Authors: Frank Hinman
Journal: JAMA (1963)

<h3>To the Editor:</h3> —The term "significant bacteriuria" was intended by Kass to provide a means of differentiating between contamination in the voided specimen and true urinary infection. It was based on the reasonable assumption that ... the common pathogens of the urinary tract multiply in the urine and, therefore, when bacteria are deposited in the urine, they tend to multiply to very large numbers, usually exceeding 10<sup>6</sup>colonies per milliliter.<sup>2</sup> The distinction between bacteriuria and contamination is "based on an analysis of the distribution of bacterial counts in nonbacteriuric and bacteriuric populations,"<sup>2</sup>so that, as Kass himself makes clear, there is no specific bacterial number for use in the detection of bacteriuria, but, rather, a degree of<i>probability</i>that a given colony count signifies either bacteriruria or contamination<i>in a voided specimen</i>. Thus, the concept of "significant bacteriuria" at the level of 100,000 colonies/ml is very useful in
Operations Performed under the Influence of Aether
Authors: W. P. Brookes
Journal: BMJ (1847)

INHALATION OF ETHER.so much clotted blood thatit appeared as if the placenta Itself was come away, which, on examining the cord and membranes was found not to be the case.On ,xamination per vaginam, the placenta was found within the os uteri, and brought away in the hand, and no trace of attachment of the cord to any part of its surface could be discovered.
913-113 Detection of Left Ventricular Involvement with 1-123 MIBG SPECT in Patients with Arrhythmogenic Right Ventricular Dysplasia: Comparison with Electron-beam CT, MRI and Left Ventriculography
Authors: Nobukazu Takahashi, Yoshio Ishida, Yoshiaki Hirose, Satio Kuribayashi, Sirou Kamakura, Makoto Takamiya
Journal: Journal of the American College of Cardiology (1995)
Reviews and Notes: Medical Diagnosis and Treatment of Alcoholism
Authors: William D. Clark
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 September 1993Reviews and Notes: Medical Diagnosis and Treatment of AlcoholismWilliam D. Clark, MDWilliam D. Clark, MDBath Memorial Hospital, Bath, ME, 04530Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-5-199309010-00041 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Medical Diagnosis and Treatment of AlcoholismJack H. Mendelson and Nancy K. Mello; eds. 699 pages. New York: McGraw-Hill; $55.00.The tragic societal losses caused by alcohol affect the work of all physicians. To what extent does this book meet the formidable challenge of enhancing the medical care system's responses?Babor's chapter succinctly and readably presents for the generalist the complex controversies regarding definitions and diagnosis of alcoholism. The delightful geriatric vignettes in Ofman's chapter vividly describe the pathos and show how coordination of services produces dramatic outcomes, even with the cognitively impaired elderly. Unfortunately, the text immediately preceding these stories iterates the ... Author, Article, and Disclosure InformationAffiliations: Bath Memorial Hospital, Bath, ME, 04530 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1993Volume 119, Issue 5Page: 443KeywordsAlcoholismAlcoholsElderlyGeriatricsNeurotransmittersPharmacokineticsPrimary care physicians ePublished: 15 August 2000 Issue Published: 1 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Psychodynamics of Hostility
Authors: Marjorie C. Meehan
Journal: JAMA (1977)

Unlike Freud, who emphasized sexual drives and did not discuss "uneroticized aggression" until very late in his life, Saul considers hostility the basis of most psychopathology and most of the problems of civilized life. He defines hostility as "a motivating force... aimed at injuring or destroying some object, animate or inanimate" and calls it "an essential evil in man." After discussing the fight-flight reflex and pointing out its inappropriateness for life today, Saul asserts that hostility is not hereditary, but is usually developed in early childhood. When parents are overprotective or neglectful, abusive or overindulgent, they are likely to produce hostility in their children that will give lasting direction to their lives. Numerous case histories show how improper parental care produces disordered motivation, conflict about dependency needs, inferiority feelings, resentment, projection, with consequent paranoid idealism, or cruel and violent behavior. Some people express hostility openly and directly, others more indirectly.
Influence of heart rate on left ventricular performance in conscious dogs.
Authors: G L Freeman, W C Little, R A O'Rourke
Journal: Circulation Research (1987)

The effects of atrial pacing on the left ventricular end-systolic pressure-volume relation, a relatively load-insensitive index of left ventricular performance, were studied in 8 chronically instrumented, conscious dogs. Six of the dogs were studied while autonomically intact, and 2 were studied after autonomic blockade with 2 mg/kg i.v. propranolol and 0.2 mg/kg i.v. atropine. Left ventricular pressure was measured with a micromanometer and left ventricular volume was determined from 3 ultrasonic orthogonal dimensions. Pressure was varied by caval occlusions at control heart rate and after atrial pacing at 100, 120, 140, 160, 180, and 200 bpm. The end-systolic pressure-volume relation was linear in every case (r = 0.97 +/- 0.03, SD). In the autonomically intact dogs, Emax, the slope of the end-systolic pressure-volume relation, was directly and monotonically related to heart rate in every dog, increasing to 238 +/- 99% of control at peak pacing rate (p less than 0.05). V0, the zero pressure intercept of the relation was also directly related to heart rate in every dog and increased 8.6 +/- 5.5 ml from control to peak pacing rate (p less than 0.05). Autonomic blockade did not attenuate these effects. This rightward shift of the end-systolic pressure-volume relation results in a reduced stroke volume from any end-diastolic volume, modulating the hemodynamic benefits of enhanced contractility. T, the time constant of isovolumic pressure fall during ventricular relaxation, was determined from beats with matched end-systolic pressures. T was related to heart rate, falling by 20 +/- 10.3% over the range of rates studied in the autonomically intact dogs and by 23.1 +/- 6.2% in the autonomically blocked dogs. Thus, the ventricle relaxes more rapidly at higher heart rates. We conclude that the frequency of contraction is concluded as an important determinant of overall pump function throughout the cardiac cycle in conscious dogs.
Review: Strength training, with or without flexibility and aerobic training, reduces pain in lower limb osteoarthritis
Authors: Ami Schattner
Journal: Annals of Internal Medicine (2013)

Source Citation Uthman OA, van der Windt DA, Jordan JL, et al. Exercise for lower limb osteoarthritis: systematic review incorporating trial sequential analysis and network meta-analysis. BMJ. 2013;347:f5555. 24055922
The Tissue Catechol Amine Concentration of the Human Heart Determined by the Aluminum Hydroxide-Arsenomolybdic Acid Method
Authors: J. M. B. BLOODWORTH, E. VON HAAM
Journal: Circulation (1956)

With the aluminum hydroxide-arsenomolybdic acid method, which has recently been extensively modified in this laboratory, the tissue concentration of catechol amines was determined in 100 human hearts. The results were correlated with clinical history and autopsy findings. Previous work has suggested that cardiovascular disease and uremia were associated with an elevation in the heart catechol amine concentration, and that some cases of sudden death were associated with an elevated heart catechol amine concentration. In this study cardiovascular disease and uremia showed low or low normal values while not a single instance of sudden death could be explained by an abnormally elevated heart catechol amine concentration.
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
Authors: Angelika Bierhaus, Thomas Fleming, Stoyan Stoyanov, Andreas Leffler, Alexandru Babes, Cristian Neacsu, Susanne K Sauer, Mirjam Eberhardt, Martina Schnölzer, Felix Lasitschka, Winfried L Neuhuber, Tatjana I Kichko, Ilze Konrade, Ralf Elvert, Walter Mier, Valdis Pirags, Ivan K Lukic, Michael Morcos, Thomas Dehmer, Naila Rabbani, Paul J Thornalley, Diane Edelstein, Carla Nau, Josephine Forbes, Per M Humpert, Markus Schwaninger, Dan Ziegler, David M Stern, Mark E Cooper, Uwe Haberkorn, Michael Brownlee, Peter W Reeh, Peter P Nawroth
Journal: Nature Medicine (2012)
Consultants' communications with general practitioners.
Authors: B. Fisher
Journal: BMJ (1992)

provincial clinic seeing around 4500 new cases a year.In two weeks 116 calls were made for results and 65 for advice (roughly 9000 annually).Most of these calls were dealt with by clerical and nursing staff, but to do so adequately they require experience and training.If telephone calls are to be used more their use should be included in routine statistics and the demand they make planned for.
Host-Parasite Relations Between Man and His Intestinal Protozoa.
Authors: Robert William Hegner
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Google as a diagnostic aid
Authors: Hangwi Tang, Jennifer H K Ng
Journal: BMJ (2006)

Use of Google as a diagnostic aid Bias your searchEditor-Although Google can be a valuable aid in reaching diagnoses in rare conditions, 1 the problem faced in a busy, fast-paced clinic can be the abundance of lesser quality material on the web."Biasing" or directing your search by adding the name of an online clinical knowledge base such as Emedicine can lead you to quality information more quickly; you avoid sifting through dozens of unknown journals, personal webpages, blogs, or discussion forums containing your search terms.For example, by typing "pigmented lesion+buccal" into Google you will get 55 000 hits with a vast array of very different material.However, typing "pigmented lesion+buccal+emedicine" provides only 106 hits (accessed 12 November 2006), the first being a comprehensive Emedicine review on Peutz-Jeghers syndrome. 2You get similar results by adding "BMJ" to the end of your search; in this case the top hit is an ABC of oral health article.