tbuckley/cabot-search huggingface dataset:
Abstract 1018: Cardiac Progenitor Cells and Biotinylated IGF-1 Nanofibers Improve Endogenous and Exogenous Myocardial Regeneration after Infarction
Authors: Yu Misao, Michael E Davis, Vincent E Segers, Marcello Rota, Grazia Esposito, Federico Mosna, Alessandro Gatti, Toru Hosoda, Konrad Urbanek, Annarosa Leri, Piero Anversa, Richard T Lee, Jan Kajstura
Journal: Circulation (2007)

Cardiac progenitor cells (CPCs) possess the IGF-1-IGF-1 receptor system which promotes cell survival, growth and differentiation. Therefore, we tested whether the local injection of CPCs together with the prolonged release of IGF-1 by self-assembling peptides enhanced myocardial regeneration after infarction. The possibility was raised that this strategy may improve cardiac repair by potentiating the regenerative response of the delivered and resident CPCs. Myocardial infarction was induced in rats and after the injection of 100,000 clonogenic immunocompatible EGFP-positive-CPCs in the border zone, biotinylated IGF-1 nanofibers were delivered to the same region. Four groups of animals were used for comparison: infarcted hearts injected with peptide only, infarcted hearts injected with CPCs only, untreated infarcted hearts and sham operated hearts. All animals received BrdU throughout the 1 month experimental period for the recognition of newly formed cells. Infarct size, ~60%, was comparable in the 4 groups. Although all treated-infarcted hearts showed a reduction in chamber volume and an increase in wall-thickness-to-chamber volume ratio and LV mass-to-chamber volume ratio, the combined treatment had the most positive effect. Similarly, LVEDP, LVDP, and dP/dt improved predominantly in infarcted hearts exposed to CPCs and IGF-1 which possessed a larger number of regenerated myocytes. The newly formed BrdU-positive myocytes consisted of EGFP-positive and EGFP-negative cells. The former category corresponded to the progeny of the injected CPCs and the latter was the product of differentiation of resident CPCs. The regenerated myocytes showed a high degree of differentiation; 20% of myocytes had a volume 2,000 –10,000 μm 3 . This level of maturation was not observed in infarcted hearts treated only with CPCs or IGF1 releasing peptides. Also, administration of CPCs and IGF-1 led to the formation of numerous resistance arterioles and capillary structures within the regenerated myocardium. Thus, the combination of CPCs and IGF-1 biotinylated nanofibers results in an unprecedented degree of myocardial recovery of structure and function after infarction. Importantly, the regenerated myocytes acquire the differentiated adult phenotype.
Paracelsus' Psychiatry: On the Occasion of the 400th Anniversary of His Book "Diseases That Deprive Man of His Reason" (1567)
Authors: GEORGE MORA
Journal: American Journal of Psychiatry (1967)

Although Paracelsus has been called a fore-runner of modern psychiatry, his thinking was and remains highly controversial, as this author points out. His approach to reality was essentially an expression of medieval philosophy; he was, however, among the first to locate the roots of the personality in passions and the will and to consider the pathos of man's existential condition between instincts and spirit.
Gliomas Induced in Dogs By the Rous Sarcoma Virus
Authors: G. G. Liddle
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Your editorial of some months ago (<b>192</b>:54, 1965) called attention to the production of tumors of the central nervous system in mice, by injection of the Rous agent. In the interim other viruses have been found to provoke somewhat similar results in small animals, especially mice, but now tumors in dogs (<i>Nature</i><b>209</b>:884, 1966) have been induced by Rabotti and others working at the National Cancer Institute. Although nonmetastasizing, the gliomatous quality of many of these has been transparent, even when companion leptomeningeal sarcomas have been present. The animals were all quite young, none as much as 8 weeks old at death, with symptoms beginning in 15 days or a little more. Evidently, symptomatology was followed rapidly by general deterioration of the animals. The potentialities of viruses for provoking neoplastic changes continue as fascinating puzzles.
The epidemiology of diet and blood pressure.
Authors: F P Cappuccio
Journal: Circulation (1992)

Epidemiological studies of diet and blood pressure support the concept that some dietary nutrients are strongly related to blood pressure and are amenable to modifications, with a likely impact on the incidence of hypertension and of related vascular events. For other potential nutrients, the evidence is more difficult to obtain. Further studies are required to establish 1) the practical value of assessment of individual nutrients versus dietary patterns in risk prediction, 2) the effects of changes of these individual nutrients versus dietary patterns on blood pressure, and 3) whether long-term changes in these individual nutrients or dietary patterns reduce the incidence of hypertension and can be implemented at a population level.
Permethrin treatment in scabies infestation: importance of the correct formulation
Authors: N H Cox
Journal: BMJ (2000)

See p 35 

In temperate countries there are epidemics of the mite infestation scabies (figs 1 and 2) every 20-30 years. The present epidemic of scabies in the United Kingdom originated in the catchment population of this hospital in early 1990 and continues to be a problem.1 Failure to treat contacts adequately and to apply treatment correctly are acknowledged problems. Cases in which genuine resistance of scabies mites seems probable have also been reported. The following cases illustrate a new pitfall that can lead to treatment failure.



Fig 1 
Scabies mite extracted from a burrow



### Family 1

A 53 year old woman and her husband acquired scabies—probably from their 25 year old son. They were all treated with topical permethrin, which was purchased “over the counter” from the pharmacist on the advice of their general practitioners. Over a period of six months the family used at least five bottles of permethrin and applied it for up to 24 hours, but with no success. Affected members consulted different general practitioners in two separate practices, and part of the reason for treatment failure may have been the fact that they were not treated concurrently from the outset. Shortly before the woman was due to attend a dermatology clinic, the family treated themselves with a malathion preparation (Derbac-M, Seton Scholl), and their symptoms resolved rapidly. The woman kept her appointment because of the duration and intensity of her symptoms (the other family members were not examined as their symptoms had resolved). At the consultation it was learned that they had been using a 1% permethrin cream rinse for head lice (Lyclear, Warner Lambert), which is not formulated to eradicate scabies infestation. The patient had apparently queried the suitability of the product at the …
European public health funding is cut back
Authors: Rory Watson
Journal: BMJ (2006)

The European Commission has been forced to cut back its public health programme over the next seven years, after receiving just a little over a third of the funding it had originally asked for.

The cutback could affect individual public health projects funded by the commission, and it has forced the commission to drop its plans to introduce measures to tackle individual diseases in member countries.

However, plans to promote cooperation among countries' health systems will still go ahead, although in a watered down …
United Kingdom grants first human embryo research licences
Authors: S. Mayor
Journal: BMJ (2002)

The UK Human Fertilisation and Embryo Authority has granted the first licences for research teams to proceed with programmes designed to develop human embryonic stem cell lines.

The authority, the regulatory body that oversees human fertilisation and related research in the United Kingdom, last week approved applications from two research groups to develop stem cell lines from human embryos. Previously, researchers have only been licensed to study embryos up to 14 days old with a view to improving infertility treatment. They were not allowed to produce human embryonic stem cell lines that were maintained long term.

A group at Edinburgh University has been licensed to develop embryonic stem cell lines to be used in studies designed to develop new therapeutic approaches to Parkinson's disease, and a team at King's College, London has been approved to use stem cells to investigate neural disorders, infertility, and miscarriage.

The …
Toward a Social Policy for Health
Authors: James C. Hurowitz
Journal: New England Journal of Medicine (1993)

Reform of the medical care system in the United States is now a political and economic priority. In the current debate, the terms “health care” and “medical care” are often used interchangeably, reflecting a cultural view that they are synonymous. As a result, health care reform is viewed primarily in medical terms.“Health care” and “medical care,” however, are not synonyms. Health care permeates all aspects of daily life. It centers on the prevention of illness. Health care includes social elements such as good housing and sanitation, a safe work environment, stable interpersonal relationships, sufficient income, and education. Medical care, . . .
Measuring the response of the jejunal mucosa in adult coeliac disease to treatment with a gluten-free diet
Authors: B. L. Chapman, K. Henry, F. Paice, N. F. Coghill, J. S. Stewart
Journal: Gut (1974)

A previously described technique for measuring changes in the architecture of the small intestinal mucosa was used to measure the long-term response in six patients with adult coeliac disease to treatment with a gluten-free diet. All had flat or flat-with-mosaic jejunal mucosae before treatment and were subsequently believed to keep strictly to a gluten-free diet. They were followed for between four and 14 months from the start of treatment. The ratio of the area of surface epithelium to that of crypt epithelium (;area ratio') invariably increased following gluten withdrawal, but did not begin to do so until after several weeks of treatment. No patient attained complete histological normality within the limited period of observation, which was never more than 14 months. In one of the three patients followed for a year or more the area ratio increased to within the control range, and in two of these three the ratio was about 10 times the pretreatment ratio. There was a highly significant linear correlation between area ratio and time on the diet (r = 0.775, p < 0.005). The surface cell height measurements for these patients, by contrast, rose steeply and almost invariably during the first few weeks of treatment, but after that they fluctuated without further significant change. It is suggested that the two methods of measurement were complementary to each other, surface cell height being useful while the patient was in hospital on a rigidly strict diet, and the area ratio after return home, when minor dietary lapses were almost invariable.
Notch1 promotes survival of E2A-deficient T cell lymphomas through pre–T cell receptor–dependent and –independent mechanisms
Authors: Erica J. Reschly, Christina Spaulding, Tomas Vilimas, W. Vallen Graham, Rachel L. Brumbaugh, Iannis Aifantis, Warren S. Pear, Barbara L. Kee
Journal: Blood (2006)
ELEVATED MID-REGIONAL PRO-ADRENOMEDULLIN IS ASSOCIATED WITH INCREASED MORTALITY IN STABLE OUTPATIENTS WITH DIASTOLIC DYSFUNCTION
Authors: Yang Xue, Pam Taub, Arrash Fard, Navaid Iqbal, Hugh Nguyen, Paul Clopton, Alan S. Maisel
Journal: Journal of the American College of Cardiology (2011)
Who May Not Have an Abortion?
Authors: Sanford Meyerowitz
Journal: JAMA (1969)

This issue (p 229) contains a straightforward account of one year's experience with the liberalized abortion law in California. Until recently, every state has had highly prohibitive abortion laws. With some minor exceptions, the only legal ground for abortion has been a judgment that continuation of the pregnancy is a threat to the life of the mother. During the past decade, interpretation of such laws in actual practice has varied considerably in different localities. There is reason to believe that the stated criterion of "a threat to the life of the mother" has at times been very broadly interpreted. For example, it may be argued that any serious deviation from mental or physical health is lifethreatening, particularly when it is difficult to predict the outcome. Since 1967, new abortion laws have been enacted in California, North Carolina, Colorado, and Maryland. There are reports of similar legislative proposals in many other
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy
Authors: Xiaojie Wang, Jiang Liu, Junhui Zhen, Chun Zhang, Qiang Wan, Guangyi Liu, Xinbing Wei, Yan Zhang, Ziying Wang, Huirong Han, Huiyan Xu, Chanchan Bao, Zhenyu Song, Xiumei Zhang, Ningjun Li, Fan Yi
Journal: Kidney International (2014)
Labeling Changes for Orlaam
Authors: Bernard A. Schwetz
Journal: JAMA (2001)

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Combined effects of docetaxel and angiostatin gene therapy in prostate tumor model
Authors: Ariane Galaup, Paule Opolon, Céline Bouquet, Hong Li, David Opolon, Marie-Christine Bissery, Thomas Tursz, Michel Perricaudet, Frank Griscelli
Journal: Molecular Therapy (2003)

The anti-tumor effects of adenovirus-delivered angiostatin (AdK3) in association with docetaxel (Taxotere) have been evaluated in a human-origin prostate tumor model. In vitro, human endothelial cells were 50- to 100-fold more sensitive to docetaxel than prostate cell lines (PC3, LNCaP, and DU145), and the combination regimen of docetaxel and AdK3 was significantly more cytotoxic for endothelial cells than either treatment alone. PC3 cells, which display the highest sensitivity to docetaxel, were then grafted onto athymic mice for an evaluation of the combined regimen as a therapy. The combination of a single intratumoral injection of AdK3 (2 x 10(9) pfu) and a single intravenous injection of docetaxel (15 mg/kg) was compared with the injection of AdK3 alone on preestablished mice bearing PC3-derived tumors with a mean tumor volume of 60 +/- 11 or 205 +/- 46 mm3. Significant antitumoral effects were observed only in mice receiving the combined treatment. We showed that all PC3 tumors regressed in the AdK3-docetaxel combination group and that 40 to 83% totally regressed. In all cases, this regimen was tightly correlated with a marked decrease in intratumoral vascularization. Our experimental data show that attacking both endothelial and tumoral compartments is an efficient and logical strategy, making this bitherapy approach clinically promising.
Physical Activity and Fibrinogen Concentration in Newly Diagnosed NIDDM
Authors: Esko Vanninen, Jaana Laitinen, Matti Uusitupa
Journal: Diabetes Care (1994)

OBJECTIVE To evaluate whether plasma fibrinogen concentration is correlated with the level of physical activity and aerobic power in patients with newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS We studied 78 middle-aged (54 ± 6 years, mean ± SD), obese (body mass index [BMI] 32 ± 5 kg/m2) patients (45 men and 33 women) before and after a 12-month treatment period consisting of either conventional treatment given by community health centers or intensified dietary and exercise education given by a university outpatient clinic. Plasma fibrinogen concentration was measured by using a coagulometer. Physical activity was assessed by a questionnaire, and the patients were classified into a sedentary group or moderately or intensively exercising groups. Aerobic power (maximum oxygen uptake [], anaerobic threshold []) was measured by direct breath-by-breath technique. RESULTS At baseline, the sedentary patients had higher fibrinogen concentration than those with moderate or high physical activities (3.8 ± 0.8 vs. 3.3 ± 0.7 g/I, P &amp;lt; 0.01). Both and (ml · min−1 · kg−1) showed an inverse linear correlation with fibrinogen (r = -0.38, P &amp;lt; 0.001, and r = -0.29, P &amp;lt; 0.01, respectively). In the step wise multiple regression analysis, BMI, Vo2 max (ml/min), and smoking were the only significant independent factors explaining 23% of the variance in fibrinogen concentration. In sedentary patients, poor glycemie control was related with high fibrinogen concentration. During the follow-up period, patients maintained, on the average, good to moderate glycemie control. The originally sedentary group showed a decrease in fibrinogen concentration (to 3.3 ± 0.7 g/I, P &amp;lt; 0.001) that reached the same level that the physically more active groups had at baseline. This change was associated with improved glycemie control, but not with any of the other assessed factors, including fatty acid composition of serum lipids reflecting dietary intake of fats. CONCLUSIONS In addition to BMI and smoking, low reported physical activity and low aerobic power are independently associated with high plasma fibrinogen concentration in newly diagnosed NIDDM.
Ghostwriting at Elite Academic Medical Centers in the United States
Authors: Jeffrey R. Lacasse, Jonathan Leo
Journal: PLoS Medicine (2010)

The authors declare that they have no financial conflicts of interest. JL and JRL are members of Healthy Skepticism, an international nonprofit organization dedicated to reducing harm from misleading drug promotion. JRL serves on the management board of Healthy Skepticism.



No specific funding was received to write this article.



Provenance: Not commissioned; externally peer-reviewed.
Burkitt Lymphoma During Pregnancy With Bilateral Breast Involvement
Authors: James O. Armitage, John R. Feagler, Donald P. Skoog
Journal: JAMA (1977)

BREAST involvement by Burkitt lymphoma is rare but occurs most frequently during pregnancy. In this case, the patient had bilateral breast involvement in the first trimester of pregnancy. Bone marrow and peripheral blood involvement were also present. Hypercalcemia accompanied by elevated parathyroid hormone levels occurred with widespread organ involvement, including CNS disease. <h3>Report of a Case</h3> In a 42-year-old white woman (gravida 10, para 6, abortus 3), tenderness and multiple nodules of both breasts developed during the third month of pregnancy. Antibiotics were prescribed without resolution, and the patient was referred for examination. Physical examination showed a 4-cm, lobular mass in the right axilla. Her breasts were large, pendulous, erythematous, and extremely tender, with extensive superficial venous distention but without specific nodules. Both the liver and spleen were enlarged, and multiple nodules were palpated in the anterior abdominal wall. The uterus was four months gestational size. A mass was palpated
Central-Nervous-System Influence on Experimentally Induced Pancreatitis
Authors: Robert B. Gilsdorf
Journal: JAMA (1965)

The etiology of acute hemorrhagic or necrosing pancreatitis has remained an enigma. Infection, 1 bile reflux, 2 metabolic changes, 3 trauma, 4 and vascular changes, 5 have been implicated and investigated in the past. Sympathetic-nervous-system influence has also been studied as a factor in the production of this lethal disease. Mallet-Guy et al have demonstrated that stimulation of the left splanchnic nerve can produce pancreatitis. They demonstrated this in experiments in 1944 in which acute pancreatitis was produced in the anesthetized guinea pigs and in experiments in 1949 in which chronic pancreatitis was produced in unanesthetized dogs. 6,7   The present investigation was initiated to further investigate the influence of excitation and overactivity of the sympathetic nervous system on pancreatitis  Methods and Materials  The study is divided into three experiments according to the different methods of producing increased sympathetic activity: (1) ablation of the anterior hypothalamic nuclei; (2) repeated electrical stimulation
CLINICAL LANGUAGE REHABILITATION OF THE VETERAN METHODS AND RESULTS
Authors: ESTI D. FREUD
Journal: American Journal of Psychiatry (1951)

This concludes a detailed account of 1 year's work of the speech therapist at the Mental Hygiene Clinic in Newark, N. J. Altogether about 100 patients have been tested, of whom 80 have been under regular treatment more than 3 months. This, our first year, has been a year of organization and of hard work. We had to earn the confidence of our co-workers in the clinic and the Veterans Administration Medical Officer's satisfaction with our achievements. Last but not least, we had to be worthy of the faith, affection, and gratitude our patients bestowed upon us. The work has been especially gratifying since most of the patients are in the prime of life and suffered their infirmities while fighting for the ideals of our country that were threatened. They deserve all the help it is possible to give. This survey has by no means exhausted the entire field of voice and speech disorders. It is hoped that the knowledge and practical experience gained over a period of more than 20 years and the diversity of the clinic's material may be utilized not only in the Veterans Administration but in mental hygiene clinics everywhere. Successful treatment of speech disorders pays big dividends in terms of restoring the individual to an economically useful life and in relieving the taxpayer of the burden of supporting individuals so handicapped. I wish to express my thanks to Dr. Thompson and Dr. Kutash.
Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial
Authors: Michael A Weber, Stevo Julius, Sverre E Kjeldsen, Hans R Brunner, Steffan Ekman, Lennart Hansson, Tsushung Hua, John H Laragh, Gordon T McInnes, Lada Mitchell, Francis Plat, M Anthony Schork, Beverly Smith, Alberto Zanchetti
Journal: The Lancet (2004)
PIMS Modulates Immune Tolerance by Negatively Regulating Drosophila Innate Immune Signaling
Authors: Nouara Lhocine, Paulo S. Ribeiro, Nicolas Buchon, Alexander Wepf, Rebecca Wilson, Tencho Tenev, Bruno Lemaitre, Matthias Gstaiger, Pascal Meier, François Leulier
Journal: Cell Host & Microbe (2008)
333 POLYUNSATURATED FATTY ACID COMPOSITION IN ERYTHROCYTE LIPID MEMBRANES IN NASH: UNEXPECTED HETEROGENEITY IN THE N6-N3 RATIO
Authors: S. Caldwell, C. Argo, A. Al-Osaimi, N. Shah, H. Lothamer, C. Harmon, J. Rodriguez
Journal: Journal of Hepatology (2010)