New Data on Preventive Treatment with Isoniazid
Authors: GEORGE W. COMSTOCK
Journal: Annals of Internal Medicine (1983)

Editorials1 May 1983New Data on Preventive Treatment with IsoniazidGEORGE W. COMSTOCK, M.D., DR. P.H.GEORGE W. COMSTOCK, M.D., DR. P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-663 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn extensive controlled trial of treatment with isoniazid to prevent the development of infectious tuberculosis among persons with fibrotic pulmonary lesions adds data important in evaluating the role of this drug in tuberculosis control (1). Important questions remain, and much of the evaluation as it pertains to an individual patient still lies with the physician; however, deciding whether to prescribe treatment for a fibrotic pulmonary lesion has now been placed on a more rational basis.With the low incidence of infectious tuberculosis among most groups in the United States and the correspondingly low level of support for tuberculosis control, it...References1. . Efficacy of various durations of isoniazid preventive therapy for tuberculosis: five years of follow-up in the IUAT trial. Bull WHO. 1982;60:555-64. MedlineGoogle Scholar2. PUFFERSTEWARTGASS RHR. Tuberculosis studies in Tennessee: subsequent course of cases observed in Williamson County. Am J Hygiene. 1938;28:490-507. Google Scholar3. COMSTOCK G. Untreated inactive pulmonary tuberculosis: risk of reactivation. Public Health Rep. 1962;77:461-70. CrossrefMedlineGoogle Scholar4. EDWARDSDOSTERLIVESAYFEREBEE LBVS. Tuberculosis risk in persons with "fibrotic" X-ray lesions. Bull Int Union Tuberc. 1972;47:151-6. Google Scholar5. FEREBEE S. Controlled chemoprophylaxis trials in tuberculosis: a general review. Adv Tuberc Res. 1970;17:28-106. Google Scholar6. COMSTOCKWOOLPERT GS. Preventive treatment of untreated, nonactive tuberculosis in an Eskimo population. Arch Environ Health. 1972;25:333-7. CrossrefMedlineGoogle Scholar7. FALKFUCHS AG. Prophylaxis with isoniazid in inactive tuberculosis: a Veterans Administration Cooperative Study XII. Chest. 1978;73:44-8. CrossrefMedlineGoogle Scholar8. FEREBEE-WOOLPERTFUJITADANKOVAKREBSVADASZ SSDAI. IUAT trial on duration of preventive treatment in persons with fibrotic lesions—first results. Bull Int Union Tuberc. 1974;49:279-305. Google Scholar9. . Preventive therapy of tuberculous infection. Am Rev Respir Dis. 1974;110:371-4. MedlineGoogle Scholar10. KREBS A. Follow-up of results of the IUAT trial on isoniazid preventive therapy of fibrotic lesions [Abstract]. Bull Int Union Tuberc. 1982;57:81. Google Scholar11. DASHCOMSTOCKFLYNN LGJ. Isoniazid preventive therapy: retrospect and prospect. Am Rev Respir Dis. 1980;121:1039-44. MedlineGoogle Scholar12. VAN DER KUYPMCCULLOUGHDANIEL FJT. Preventive treatment of tuberculosis. [Abstract]. Bull Int Union Tuberc. 1982;57:81. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA Guide to the Management of Tuberculosis in Patients with Chronic Liver DiseaseHonors and Awards * Bibliography of Peer-Reviewed Journal ArticlesChemotherapy for Osteoarticular TuberculosisA novel approach to monitoring adherence to preventive therapy for tuberculosis in adolescenceCompliance with Antituberculosis Regimens and the Role of Behavioral InterventionsElectronic compliance assessment of antifungal prophylaxis for human immunodeficiency virus-infected womenIsoniazid-associated rhabdomyolysisCommercial cognitive/memory systems: A case studyUse of Automated Telephone Reminders to Increase Elderly Patients' Adherence to Tuberculosis Medication AppointmentsFactors associated with compliance in treatment of tuberculosis¿Puede acortarse la quimioprofilaxis de la tuberculosis? a la búsqueda de una quimioprofilaxis corta de la tuberculosisPrevention of Tuberculosis with IsoniazidH. THOMAS FOLEY, M.D., J.D., ROBERT F. DONOHOE, M.D. 1 May 1983Volume 98, Issue 5_Part_1Page: 663-665KeywordsDrug regulationDrugsIsoniazidLesionsPulmonary diseasesTuberculosis Issue Published: 1 May 1983 PDF DownloadLoading ...