tbuckley/cabot-search huggingface dataset:
HLA antigens in nickel-sensitive contact dermatitis patients
Authors: Shernaz Walton, K. Keczkes
Journal: British Journal of Dermatology (1987)

Journal Article HLA antigens in nickel‐sensitive contact dermatitis patients Get access Shernaz Walton, Shernaz Walton Department of Dermatology, Hull Royal Infirmary, Hull HU3 2JZ, U.K. Search for other works by this author on: Oxford Academic Google Scholar K. Keczkes K. Keczkes Department of Dermatology, Hull Royal Infirmary, Hull HU3 2JZ, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 116, Issue 4, 1 April 1987, Pages 607–608, https://doi.org/10.1111/j.1365-2133.1987.tb05890.x Published: 01 April 1987
Suboptimal dosing of rituximab in male and female patients with DLBCL
Authors: Michael Pfreundschuh, Carsten Müller, Samira Zeynalova, Evelyn Kuhnt, Martin H. J. Wiesen, Gerhard Held, Tanja Rixecker, Viola Poeschel, Carsten Zwick, Marcel Reiser, Norbert Schmitz, Niels Murawski
Journal: Blood (2013)
The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2.
Authors: P D'Eustachio, B Fein, J Michaelson, B A Taylor
Journal: The Journal of Experimental Medicine (1984)

DNA sequences homologous to adult alpha-globin genes are dispersed in the mouse. Two functional genes are tightly linked on chromosome 11. Pseudogenes have been assigned to chromosomes 15 and 17 by analysis of interspecies somatic cell hybrids. We have now further characterized the second of these pseudogenes, Hba-a4. The gene is highly polymorphic, with three forms occurring in a panel of 15 inbred strains and a fourth occurring in an inbred strain derived from M. m. molossinus. Analysis of Hba-a4 alleles in CXB, BXH, and AKXL recombinant inbred strains placed Hba-a4 6.60 +/- 3.14 cM centromeric to H-2. Analysis of congenic mouse strains confirmed the linkage and the gene order. Hba-a4 is the first mammalian dispersed pseudogene to be localized in a linkage map, and should provide a useful marker for the region of chromosome 17 proximal to H-2.
Packing for the Road
Authors: Corey Fogleman
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conflicts of Interest in Approvals of Additives to Food Determined to Be Generally Recognized as Safe
Authors: Thomas G. Neltner, Heather M. Alger, James T. O’Reilly, Sheldon Krimsky, Lisa A. Bero, Maricel V. Maffini
Journal: JAMA Internal Medicine (2013)

Food and Drug Administration (FDA) guidance allows food manufacturers to determine whether additives to food are "generally recognized as safe" (GRAS). Manufacturers are not required to notify the FDA of a GRAS determination, although in some instances they notify the agency. The individuals that companies select to make these determinations may have financial conflicts of interest.To determine the extent to which individuals selected by manufacturers to make GRAS determinations have conflicts of interest between their obligations to ensure that the use of the additive is safe and their financial relationships to the company. DESIGN Using conflict of interest criteria developed by a committee of the Institute of Medicine, we analyzed 451 GRAS notifications that were voluntarily submitted to the FDA between 1997 and 2012.Number of GRAS notices submitted to the FDA; frequency of various types of relationships between decision maker and additive manufacturer; frequency of participation on GRAS panels by individuals; and number of GRAS safety determinations identified by the FDA that were not submitted to the agency.For the 451 GRAS notifications, 22.4% of the safety assessments were made by an employee of an additive manufacturer, 13.3% by an employee of a consulting firm selected by the manufacturer, and 64.3% by an expert panel selected by either a consulting firm or the manufacturer. A standing expert panel selected by a third party made none of these safety assessments. The 290 panels that made GRAS determinations had an average of 3.5 members, with a maximum of 7. Ten individuals served on 27 or more panels; 1 individual served on 128 panels (44.1%). At least 1 of the 10 individuals with the most frequent service was a member of 225 panels (77.6%).Between 1997 and 2012, financial conflicts of interest were ubiquitous in determinations that an additive to food was GRAS. The lack of independent review in GRAS determinations raises concerns about the integrity of the process and whether it ensures the safety of the food supply, particularly in instances where the manufacturer does not notify the FDA of the determination. The FDA should address these concerns.
Points: Allergy to Silastic foam dressing
Authors: L E Hughes
Journal: BMJ (1985)

SIR,-YOU may be one of those who plan your Christmas shopping well in advance, or one who leaves it until the very last minute.But however you set about this annual task I am asking you to spare a thought for those for whom Christmas brings little joy and probably some anxiety.I am referring to those beneficiaries of the Royal Medi- cal Benevolent Fund; some are doctors, some are widows with children, all are in need of our help and may be faced with prospect of having little with which to celebrate Christmas.The object of the Christmas appeal of the Royal Medical Benevolent Fund is to enable us to send financial gifts to our 780 beneficiaries this Christ- mas and also in Christmases to come.These are a special addition to the awards that we make throughout the year.The fund knows through the many letters received how much this little extra means, enabling those less fortunate than our- selves to have at least some joy and warmth at Christmas.
Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease.
Authors: R S Walmsley, M H Zhao, M I Hamilton, A Brownlee, P Chapman, R E Pounder, A J Wakefield, C M Lockwood
Journal: Gut (1997)

BACKGROUND: Bactericidal/permeability-increasing protein (BPI), a constituent of primary neutrophil granules, is a potent natural antibiotic and an antineutrophil cytoplasm antibody (ANCA) antigen in cases of vasculitis in which the target antigen is neither myeloperoxidase (MPO) nor proteinase-3 (PR3). AIM: To investigate BPI as a possible target antigen for ANCAs in inflammatory bowel disease. METHODS: ANCAs were detected by routine immunofluorescence (IIF) and solid phase enzyme linked immunosorbent assay (ELISA) performed for antibodies to the purified neutrophil granule proteins; MPO, PR3, cathepsin-G, lactoferrin, and BPI in serum samples from 88 patients with inflammatory bowel disease (36 with Crohn9s disease, 52 with ulcerative colitis). Thirty patients with bacterial enteritis acted as controls. RESULTS: Significantly more patients with ulcerative colitis were ANCA positive by IIF (60%) than patients with Crohn9s disease (28%) or infectious enteritis (23%) (p &lt; 0.001). IgG anti-BPI antibodies were present in 29% of patients with ulcerative colitis, 14% of patients with Crohn9s disease, and 23% of patients with infectious enteritis, occurring in 44% of those patients with inflammatory bowel disease who were ANCA positive by IIF. Antibodies to other ANCA antigens were rare. The presence of ANCAs was not related to either disease activity or extent; presence of anti-BPI antibodies was significantly related to both a lower serum albumin concentration (p = 0.001) and a higher erythrocyte sedimentation rate (p = 0.02) in patients with ulcerative colitis, and to colonic involvement in patients with Crohn9s disease (p = 0.01). CONCLUSION: BPI is a significant minority target antigen for ANCAs in inflammatory bowel disease that seems related to colonic Crohn9s disease and disease activity in ulcerative colitis. Anti-BPI antibodies occur in infectious enteritis.
Management of Diabetic Retinopathy
Authors: Quresh Mohamed, Mark C. Gillies, Tien Y. Wong
Journal: JAMA (2007)

ContextDiabetic retinopathy (DR) is the leading cause of blindness in the working-aged population in the United States. There are many new interventions for DR, but evidence to support their use is uncertain.ObjectiveTo review the best evidence for primary and secondary intervention in the management of DR, including diabetic macular edema.Evidence AcquisitionSystematic review of all English-language articles, retrieved using a keyword search of MEDLINE (1966 through May 2007), EMBASE, Cochrane Collaboration, the Association for Research in Vision and Ophthalmology database, and the National Institutes of Health Clinical Trials Database, and followed by manual searches of reference lists of selected major review articles. All English-language randomized controlled trials (RCTs) with more than 12 months of follow-up and meta-analyses were included. Delphi consensus criteria were used to identify well-conducted studies.Evidence SynthesisForty-four studies (including 3 meta-analyses) met the inclusion criteria. Tight glycemic and blood pressure control reduces the incidence and progression of DR. Pan-retinal laser photocoagulation reduces the risk of moderate and severe visual loss by 50% in patients with severe nonproliferative and proliferative retinopathy. Focal laser photocoagulation reduces the risk of moderate visual loss by 50% to 70% in eyes with macular edema. Early vitrectomy improves visual recovery in patients with proliferative retinopathy and severe vitreous hemorrhage. Intravitreal injections of steroids may be considered in eyes with persistent loss of vision when conventional treatment has failed. There is insufficient evidence for the efficacy or safety of lipid-lowering therapy, medical interventions, or antivascular endothelial growth factors on the incidence or progression of DR.ConclusionsTight glycemic and blood pressure control remains the cornerstone in the primary prevention of DR. Pan-retinal and focal retinal laser photocoagulation reduces the risk of visual loss in patients with severe DR and macular edema, respectively. There is currently insufficient evidence to recommend routine use of other treatments.
Serendipitous Detection of Testicular Seminoma on F-18 FDG Positron Tomography
Authors: Iftikhar Ali, William Johns, Bradford Bottger, Shiv M. Gupta
Journal: Clinical Nuclear Medicine (2007)

A 52-year-old man with a history of adenocarcinoma of the sigmoid colon and hepatic metastases underwent F-18 FDG PET scan. There was no evidence of active or recurrent metastatic colon cancer. However, focal hypermetabolic activity in the scrotum was noted. A subsequent scrotal ultrasound revealed a hypoechoic heterogeneous lesion with microcalcification in the posterior aspect of the right testis. At surgery, a right testicular mass was confirmed and right inguinal/radical orchiectomy was performed. Histology showed seminoma (classic type) within the testicular parenchyma without infiltration to the tunica albuginea.
Effect of Bilirubin UDP Glucuronosyltransferase 1 Gene TATA Box Genotypes on Serum Bilirubin Concentrations in Chronic Liver Injuries
Authors: Hisashi Doyama, Toshihide Okada, Tomomi Kobayashi, Ayako Suzuki, Yasuo Takeda, Hiroshi Mabuchi
Journal: Hepatology (2000)

TATA box abnormality in the promoter region of the bilirubin UDP glucuronosyltransferase 1 gene has been reported to cause Gilbert's syndrome in white subjects. It has also been reported that the majority of Japanese patients with Gilbert's syndrome are heterozygous for Gly71Arg in the coding region of this gene. On the other hand, some patients with chronic hepatitis often show signs of unexpected hyperbilirubinemia. The aims of this study were to determine which of the genetic variations, TATA box genotype or codon 71 genotype, is most closely related to serum bilirubin concentrations, and whether the TATA box genotype has an effect on serum bilirubin concentrations in patients with hepatitis C-associated chronic liver diseases. In a sample of 300 individuals selected from among the general Japanese population, mean concentrations of total serum bilirubin differed significantly among TATA box genotypes, but not among codon 71 genotypes. Concentration of total serum bilirubin was significantly correlated with TATA box genotypes. In 211 patients with hepatitis C-associated chronic liver diseases, mean concentrations of total serum bilirubin also differed significantly among TATA box genotypes. In patients with chronic hepatitis C, concentration of total serum bilirubin was significantly correlated with TATA box genotypes. In summary, TATA box genotypes, but not codon 71 genotypes, are closely related to serum bilirubin concentrations. TATA box genotypes should therefore be considered when evaluating hepatic function by serum bilirubin concentrations in cases of hepatitis C-associated chronic liver diseases.
The Management of Leprosy and Its Complications
Authors: John R. Trautman
Journal: New England Journal of Medicine (1965)

THE number of cases of leprosy existing in the world is difficult to estimate, but it is thought that there are at least 20,000,000. About 2500 cases are known to exist in the United States; quite possibly, however, the actual number is two or three times greater.Leprosy is usually not difficult to recognize provided the diagnosis is considered but it can mimic various conditions, including dermatophytoses, lupus erythematosus, sarcoidosis, psoriasis, seborrheic dermatitis, granuloma annulare, acne and "allergy." The clinical manifestations of leprosy result primarily from invasion of the skin, mucous membranes and peripheral nerves by the Mycobacterium leprae, . . .
Antianginal effects of intravenous nitroglycerin over 24 hours.
Authors: D Zimrin, N Reichek, K T Bogin, G Aurigemma, P Douglas, B Berko, H L Fung
Journal: Circulation (1988)

To determine the constancy of hemodynamic and antianginal effects of the constant infusion of intravenous nitroglycerin (NTG) and their relationship to infusion rate and plasma NTG concentration, we administered maximal tolerated doses of intravenous NTG (range 10 to 120 micrograms/min, mean = 52 +/- 33 micrograms/min) and placebo to 10 patients with chronic stable angina for 25 hr each in a randomized, double-blind fashion. Sublingual NTG (0.4 mg) was given at 24.5 hr of infusion as a positive control. Bicycle exercise time (NIH protocol), blood pressure, heart rate, exercise ST response, and venous plasma NTG were determined before and at 1, 4, 8, 24, and 24.5 hr. Plasma NTG was linearly related to infusion rate, reached a steady state within 15 min and was unchanged over 24 hr (mean = 5.5 +/- 1.2 ng/ml). Mean plasma NTG clearance was 9.3 liters/min. However, during dose titration, patients demonstrated different relationships between plasma NTG and hemodynamic effects, with widely varying slopes and intercepts. Intravenous NTG produced a sustained reduction in blood pressure and a rise in heart rate at rest, and a reduction in blood pressure during submaximal exercise at as late as 24 hr, associated with reduced submaximal ST segment abnormality. In contrast, exercise tolerance to onset of angina showed a marked initial increase on intravenous NTG but fell progressively and did not differ from that with placebo at 24 hr. Increased exercise tolerance was associated with an increase in maximal heart rate and double product (heart rate X blood pressure), suggesting that direct coronary vasodilation and/or reduced left ventricular volume were the principal determinants of increased exercise tolerance.(ABSTRACT TRUNCATED AT 250 WORDS)
Quantities of qualia
Authors: Michael S. C. Thomas, Anthony P. Atkinson
Journal: Behavioral and Brain Sciences (1999)

We address two points in this commentary. First, we question the extent to which O'Brien &amp; Opie have established that the classical approach is unable to support a viable vehicle theory of consciousness. Second, assuming that connectionism does have the resources to support a vehicle theory, we explore how the activity of the units of a PDP network might sum together to form phenomenal experience (PE).
Abstract 4603: Optically-guided surgical approach using fluorescence visualization can significantly improve locoregional recurrence and overall survival for early stage oral cancer
Authors: Catherine F.Y. Poh, Donald W. Anderson, J. Scott Durham, Kenneth W. Berean, P. Michele Williams, Calum E. MacAulay, MIriam P. Rosin
Journal: Cancer Research (2012)

Abstract Recurrence following excision of high-grade dysplasia (HGD, severe dysplasia and carcinoma in situ) or squamous cell carcinoma (SCC) implies that the presence of subclinical changes at the margins is not apparent at surgery, resulting in incomplete excision. Fluorescence visualization (FV) has shown its value in identifying clinically not apparent high-risk oral lesions. The objective of this study is to assess the effectiveness of FV-guided surgery in reducing the loco-regional recurrence and improving overall survival. Method: From September 1st 2004 to August 31, 2009, 264 consecutive patients diagnosed with T1/T2 SCC or HGD were registered at the BC Cancer Agency and treated with surgical excision with intent to cure. Among these, 246 patients (93%; SCC, 132; HGD, 114) had a follow-up period of at least 6 months. Among these patients, 149 had the surgery done under FV guidance (FV group) while the other 97 were treated with conventional surgery procedure (control group). The outcome measurements include pathology-proven local recurrence to severe dysplasia or higher requiring another surgical procedure, regional failure, and death at follow-up. Time to outcome curve was estimated by the Kaplan-Meier method. Results: There is no significant difference between FV and control groups in age, smoking habit, lesion anatomical site, diagnosis, tumor size, and previous cancer history. There were more females in the FV group (51% vs. 33%, P = 0.006). With an average of 40 months follow-up, the FV group shows significantly lower local recurrence (7% vs. 38%), regional failure (6% vs. 23%), and death (5% vs. 20%), and significant longer time to recurrence (P &amp;lt; 0.0001), regional failure (P = 0.0007), and death of disease (P = 0.004). Conclusion: Although they are retrospectively collected from a single centre, the data have strongly demonstrated that the use of FV for surgical margin decision can significantly improve outcomes of the early stage oral cancer. An on-going 5-year multi-centre phase III randomized surgical trial (the COOLS trial), funded by Terry Fox Research Institute, has started to recruit patients and the data will be used to validate the results of this study. (Supported by R01 DE17013 from the National Institute of Dental and Craniofacial Research, CCSRI-20336 from Canadian Cancer Society Research Institute, and TFRI-2009-24 from Terry Fox Research Institute. CFP is currently supported by a Scholar Award from the Michael Smith Foundation for Health Research). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4603. doi:1538-7445.AM2012-4603
Bleeding Disorders: Investigation and Management
Authors: Virginia H. Donaldson
Journal: JAMA (1966)

With this book, Hardisty and In-gram make a notable contribution to the literature of blood coagulation. By concisely relating theory to diagnosis and practical management, they provide a desirable addition to the libraries of those who deal with hemorrhagic disorders. The authors begin by defining suitable diagnostic approaches to patients with hemorrhagic tendencies. Then follows a discussion of the life-long bleeding disorders in which genetic counseling is considered in managing the hereditary aspects of these syndromes. The authors also include valuable reminders concerning the dental, orthopedic, socioeconomic, and educational needs of the affected members of blighted kindreds. Although animal plasma fractions are not now available for use in this country, the discussion of the pros and cons of this type of replacement therapy for inherited clotting disorders deserves attention. Such timely subjects as hemorrhagic complications of extracorporeal circulation and of transfusion are included in a section on acquired bleeding disorders.
The “Gender Gap” in Authorship of Academic Medical Literature — A 35-Year Perspective
Authors: Reshma Jagsi, Elizabeth A. Guancial, Cynthia Cooper Worobey, Lori E. Henault, Yuchiao Chang, Rebecca Starr, Nancy J. Tarbell, Elaine M. Hylek
Journal: New England Journal of Medicine (2006)

Participation of women in the medical profession has increased during the past four decades, but issues of concern persist regarding disparities between the sexes in academic medicine. Advancement is largely driven by peer-reviewed original research, so we sought to determine the representation of female physician-investigators among the authors of selected publications during the past 35 years.
SYSTEMIC ENDOTHELIN RECEPTOR BLOCKADE IN ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Christopher Adlbrecht, Martin Andreas, Bassam Redwan, Klaus Distelmaier, Julia Mascherbauer, Gilbert Beran, Alexandra Kaider, Michael Wolzt, Ioana-Alexandra Tilea, Thomas Neunteufl, Georg Delle-Karth, Gerhard Kreiner, Gerald Maurer, Irene M. Lang
Journal: Journal of the American College of Cardiology (2011)