tbuckley/cabot-search huggingface dataset:
Minimal residual disease in mycosis fungoides follow-up can be assessed by polymerase chain reaction
Authors: E. Poszepczynska-Guigne, M. Bagot, J. Wechsler, J. Revuz, J-P. Farcet, M-H. Delfau-Larue
Journal: British Journal of Dermatology (2003)

T-cell receptor (TCR) gene rearrangement analysis, i.e. T-cell clonality, using polymerase chain reaction (PCR) is a routine method used to assess the presence of a cutaneous dominant T-cell clone in mycosis fungoides (MF).To compare the outcome of cutaneous lesions of MF after treatment with the fate of the cutaneous T-cell clonality, and to determine whether minimal residual disease can be detected in patients in clinical complete remission.Fifty-one patients histologically diagnosed as having MF (17 stage IA, 21 stage IB and 13 stage III) were included in this retrospective study. T-cell clonality was analysed by GC-clamp multiplex PCRgamma-denaturing gradient gel electrophoresis. Every patient had two cutaneous biopsies at least 3 months apart. The second biopsy was performed at the site of a treated lesion.The presence or absence of a dominant T-cell clone in the skin remained identical in 26 of the 31 (84%) patients with persistent disease. Thirteen patients with a detectable dominant T-cell clone at diagnosis went into complete clinical remission. In nine of these 13 (69%) patients, the T-cell clone was no longer detectable after treatment. The remaining four (31%) patients had an unchanged T-cell clonality.The TCR gene rearrangement imprint is a stable and reliable tumour marker of MF disease. One-third of patients in complete clinical remission had a cutaneous molecular residual disease, the prognostic value of which will be analysed in an ongoing prospective study.
Visualization of Pulmonary Artery Occlusion by Photoscanning
Authors: Thomas P. Haynie
Journal: JAMA (1963)

INERT CERAMIC MICROSPHERES containing beta emitting radioisotopes have been injected into the arterial supply of human cancers for irradiation treatment purposes.<sup>1-3</sup>Tissue counting radioautography revealed an even distribution pattern in the lungs when the microspheres were infused into the external jugular vein of the dog. Of the microspheres, 96 to 100% were found to be filtered out and retained in the arterioles of the lungs. We have used gamma emitting radioisotopes in these microspheres to visualize the lungs with a photoscanner.<sup>4</sup> <h3>Methods</h3> Ceramic microspheres 50±10 μ in diameter and containing Hg<sup>203</sup>with a radioactivity content of 5 μc of radioactivity per mg of labelled spheres were injected into the saphenous veins of mongrel dogs weighing about 12 kg (24.2 lb), during sodium pentothal anesthesia. Doses of microspheres weighing from 10 to 60 mg and assaying from 50 to 100 μc of radioactivity were administered in from 1
Prednisolone, but not valacyclovir, reduced time to complete recovery of facial-nerve function in Bell palsy
Authors: Doron D. Sommer, Sarfaraz Banglawala
Journal: Annals of Internal Medicine (2009)

Source Citation Engström M, Berg T, Stjernquist-Desatnik A, et al. Prednisolone and valaciclovir in Bell’s palsy: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet Neurol. 2008;7:993-1000. 18849193
Increase in reports of toxicity from fat burning supplement seen in UK
Authors: J. Wise
Journal: BMJ (2014)

Poisons centres in the United Kingdom have seen a sharp increase in reports of toxicity from a fat burning supplement called 2,4 dinitrophenol (DNP).

The supplement, used by body builders and dieters, is not licensed for medicinal use but is available on the internet. The benzene based chemical was originally used in the manufacture of dyes, wood preservatives, photographic developers, explosives, and insecticides. It was developed as a weight reducing drug in the 1930s but …
P26 Home serial spirometry as an adjunct in the diagnosis of vocal cord dysfunction
Authors: S. Y. Barnett, B. Ziso, S. J. Quantrill
Journal: Thorax (2010)

<h3>Introduction</h3> The diagnosis of vocal cord dysfunction (VCD) is often difficult. Visualisation of the vocal cords using laryngoscopy is the current gold standard method of diagnosis, but may not be diagnostic if carried out when the patient is asymptomatic. An inspiratory flow volume manoeuvre performed during spirometry aids diagnosis, indicating inspiratory flow obstruction when flattened, but is subject to the same problem. Home serial spirometry (HSS), however, may improve diagnostic yield as it can be performed on demand, when the patient experiences symptoms. <h3>Methods</h3> A retrospective review was performed of all patients referred to a District General Hospital with symptoms suggestive of VCD, between May 2005 and July 2010. Static spirometry was performed by a lung physiologist within the department. Patients were educated to perform HSS using a Jaeger Spiropro<sup>@</sup>+ handheld spirometer immediately on experiencing symptoms. Results were downloaded when the machine was returned after a 2-week period. Direct visualisation of the vocal cords via laryngoscopy was performed by a respiratory physician. <h3>Results</h3> 54 patients were investigated for possible VCD. A final diagnosis of VCD was made in 31 (57%) cases. Inspiratory loop flattening on static spirometry was present in 48/54 (88%) patients investigated and 28/31 (90%) confirmed cases of VCD. There was evidence of inspiratory loop flattening on HSS in 28/39 (71.7%) patients. 22/39 (56%) who had laryngoscopy were found to have evidence of VCD. 25 patients had both laryngoscopy and HSS performed: 14 of these had evidence of VCD on both tests. 3 of the positive laryngoscopy results were associated with normal HSS. There were eight cases with flattened inspiratory loops on HSS in patients in whom no abnormality was found on laryngoscopy. <h3>Conclusion</h3> The nature of laryngoscopy, necessarily performed at one point in time, limits its value in the diagnosis of VCD. HSS is a useful non-invasive test that can increase diagnostic yield in VCD.
Raised serum alkaline phosphatase and aspartate transaminase levels in two rheumatoid patients treated with sulphasalazine.
Authors: M Farr, D P Symmons, P A Bacon
Journal: Annals of the Rheumatic Diseases (1985)

Hepatotoxicity is a rare complication of sulphasalazine therapy in ulcerative colitis. This report describes two rheumatoid patients in whom raised serum levels of liver enzymes occurred soon after starting sulphasalazine treatment for their arthritis. In both cases the serum enzyme levels returned to normal after stopping the drug. Drug-induced hepatotoxicity should be considered in patients with rheumatoid arthritis (RA) who develop raised serum levels of liver enzymes while taking sulphasalazine.
A novel technique for biliary strictures that cannot be passed with a guide wire
Authors: G. Ersoz, F. Tekin, O. Ozutemiz, O. Tekesin
Journal: Endoscopy (2007)

Bile leaks and strictures are the main biliary complications diagnosed by endoscopic retrograde cholangiopancreatography (ERCP) in living donor living transplantation (LDLT) patients. Endoscopic management is difficult mainly because of the complexity of duct-to-duct reconstruction. Recently, we have experienced five right-lobe LDLT cases with cholangitis in which ERCP revealed S-shaped anastomotic stricture ([Figure 1 a]). The S-shaped stricture could not be passed with a guide wire, despite many maneuvers and changing positions of the sphincterotome and standard balloon. However, it became possible to pass the stricture with the guide wire by a novel method; the standard balloon was inflated near the stricture in the distal part of the common bile duct ([Figure 1 b]). The inflated balloon was pulled slowly. After the common bile duct had become slightly stretched, it was possible to pass the stricture with the guide wire ([Figure 1 c]). Thereafter, we were able to perform balloon dilation and plastic stent placement in all cases ([Figure 1 d]). We believe that this novel technique is effective for S-shaped anastomotic strictures that cannot be passed with a guide wire.
Financing Indigent Care: Short- and Long-term Strategies
Authors: Carol M. McCarthy
Journal: JAMA (1988)

HISTORICALLY, most indigent care has been financed in three ways: cost shifts to insured patients, public insurance programs such as Medicaid, and state and local appropriations to public hospitals and other providers. In the past decade, however, cost-containment efforts in the public and private sectors, coupled with increased competition in the health care industry, have disrupted traditional ways for financing indigent care at the very time such care is most needed. Changes in Medicare reimbursement methods and commercial insurance practices have made it extremely difficult for hospitals to subsidize indigent care through cost shifts to other payers. At the same time, the ranks of the uninsured have swelled. Medicaid coverage of the poor has plummeted from 65% to 38%, and to below 25% in many states.<sup>1,2</sup>Within the employed population, in 1985 there were 17 million uninsured workers— 3.1 million more than in 1982. Nearly three fourths of the
Amniotic Fluid Embolism-Reply
Authors: Kris Sperry
Journal: JAMA (1986)

In Reply.—  About an hour before the morning mail, which brought a copy of the letter by Drs Rodgers and Heymach for my review, I received a telephone call from a man in the Midwest, who had lost his wife to AFE in the early part of May, nine hours after the cesarean delivery of triplets. Now, left with six children, he is trying to understand the event that took his wife so suddenly and sought to offer the information about her clinical course to me in order that some other life might be someday saved.  I was therefore heartened to read their communication relating the successful treatment of a case of AFE with cryoprecipitate, to accomplish fibronectin repletion. As the mortality of AFE is so high (despite all known methods of support), and its occurrence so uncommon, it is clear that a sequential, controlled trial of new therapeutic modalities
Medical laboratory technology
Authors: Eleanor Berman
Journal: JAMA (1963)

For many years there has been great need for a single-volume laboratory manual which not only describes practical methodology and the relative merits of various procedures, but also presents clearly the underlying theory and basic physiology and pathology that any specific method is trying to assess. The present volume aims at achieving this goal. It covers all facets of medical technology as practiced in an average general hospital. The degree of emphasis placed on each facet appears related to the expected needs of the technician. In most laboratory texts too much emphasis is placed on some procedures and not enough on others. Explanations may be too involved or not sufficiently definitive. One highly-regarded recent volume has excellent chapters on serological procedures and sputum analysis, for example, but a rather meager section on the endocrines. Another current text includes 21 pages on hospital epidemiology. The technician in an average general hospital
Synthetic Vasopressin Nasal Spray in the Treatment of Diabetes Insipidus
Authors: Alfred M. Dashe, Charles R. Kleeman, J. Walter Czaczkes, Howard Rubinoff
Journal: JAMA (1964)

THE LONG-TERM treatment of vasopressinsensitive diabetes insipidus remains a complex and challenging problem. Vasopressin is available for therapy as an oil-repository material, vasopressin tannate injection (Pitressin Tannate in oil), in aqueous solution, vasopressin injection (Pitressin), and in powder form administered by nasal insufflation, posterior pituitary powder. These forms have certain drawbacks and more convenient therapeutic materials are desirable.  Recently, the use of synthetic lysine vasopressin, lysyl-8-vasopressin, as a nasal spray has been studied. 1-3 We wish to report our experience to date with this material in 19 patients with vasopressinsensitive diabetes insipidus. Antidiuretic hormone (ADH) levels and disappearance curves in blood have been studied in three patients 4 ; clinical response to the medication is reported here.  Methods  Lysyl-8-vasopressin spray was provided in 5 ml (50 IU per milliliter) squeeze bottle containers. Two lines of investigation were followed. In the first, three patients (cases 3, 10, and 11) were studied in
Clearing the Fields: Solutions to the Global Land Mines Crisis
Authors: E. O'Brien
Journal: BMJ (1995)

Ed Kevin M Cahill Basic Books/Council on Foreign Relations, $25, pp 237 ISBN 0 465 011772 2

Clearing the Fields is a collection of essays arising from a symposium held in New York last year. It is a most disturbing book, which is already influencing discussions taking place in many nations and organisations such as the UN. Those who read it cannot but feel an overwhelming sense of disgust at what is being perpetrated in so many not-so-distant lands.

What happens when a farmer tilling his field steps on a mine, or a child scoops the clay to grasp the brightly coloured plastic that beckons from the soil? The short answer is that the victim is left not just without an arm or leg—or often both legs and …
S24 A self-management programme of activity, coping and education (SPACE) for COPD: A randomised non-inferiority trial in a pulmonary rehabilitation population: Abstract S24 Table 1.
Authors: E Horton, K Mitchell, V Johnson-Warrington, L Apps, H Young, S Singh, S Singh
Journal: Thorax (2013)

<h3>Introduction</h3> Self-managed programmes for patients with COPD offer an alternative to conventional pulmonary rehabilitation (PR). Previously reported self management (SM) programmes either offer short education sessions or action plans or are long intensive programme with a high level of support which are more comprehensive than tradition UK PR programmes. There is limited data reported on self managed approaches to PR which offer minimal support for education, skills acquisition and exercise in comparison to PR in the UK. We have recently developed a SM programme for patients with COPD (SPACE for COPD) and have completed studies in primary care<sup>1</sup>. The demand for PR is high but the service is compromised by limited access and drop out rates. Therefore the aim of this study was to determine if SPACE for COPD is noninferior to (as good as) PR for patients with COPD over 7 weeks. <h3>Methods</h3> 287 patients (187 male: mean (SD) age 67 (9) yrs; FEV<sub>1</sub> 1.25 (0.55); BMI 27.63 (6.22) kg/m<sup>2</sup>) with COPD were consented and randomised to either SPACE for COPD or PR. Those who were assigned to the SPACE for COPD group received an introduction to the SPACE for COPD manual and 2 telephone calls at 2 and 4 weeks. Those assigned to PR received 14, 2 hour sessions of education and exercise over 7 weeks. The primary outcome was the Chronic Respiratory Questionnaire (CRQ) dyspnoea, with secondary measure of CRQ fatigue, emotion and mastery, Incremental Shuttle Walk Test (ISWT) and Endurance Shuttle Walk Test (ESWT). Measures were taken at baseline and 7 weeks. Within and between group differences were analysed using paired and unpaired t-tests respectively. <h3>Results</h3> Please see table 1. <h3>Conclusion</h3> SPACE for COPD can improve dyspnoea and endurance capacity over 7 weeks to a similar level to PR, although it remains unclear to its noniferiority to PR. The SPACE for COPD programme does offer a number of health benefits despite it involving limited support and could offer a suitable alternative to patients with COPD who would otherwise not attend conventional rehabilitation. <h3>References</h3> Mitchell-Wagg K <i>et al</i>. (2012). <i>Thorax</i> 67 (Suppl_2) A25–26.
Skeletal Muscle Peripheral T-Cell Lymphoma
Authors: Todd J. Alekshun, Dorna Rezania, Ernesto Ayala, Hernani Cualing, Lubomir Sokol
Journal: Journal of Clinical Oncology (2008)

Skeletal Muscle Peripheral T-Cell LymphomaA 56-year-old previously healthy male presented for further evaluation of a 7-month history of progressive right ankle swelling.An ultrasound of the affected limb demonstrated thrombophlebitis.Additionally, a mass involving the medial aspect of his right thigh was incidentally detected.Magnetic resonance imaging (MRI) revealed a 5.6-cm heterogeneous mass involving the right sartorius muscle, which was suspicious for a soft tissue sarcoma.Contrasted computed tomography (CT) scans of the thorax, abdomen, and pelvis revealed no evidence of mediastinal lymphadenopathy, lung infiltrates, retroperitoneal lymphadenopathy, or pelvic masses.There were no pathologic abnormalities involving his osseous structures.He underwent complete resection of the mass.The pathology demonstrated tumor infiltrating the muscle as an extensive, vaguely nodular proliferation of atypical lymphocytes ranging in size from small to large cells admixed with clusters of epithelioid histiocytes destroying muscle bundles (Fig 1, arrows) and creating intervening bands of collagen sclerosis (arrow head).Immunohistochemical staining revealed that the atypical lymphocyte populations were positive for CD3, CD4, CD5, weakly CD57, and negative for CD8, CD20, CD30, and CD56.Cytoplasmic CD3e expression by immunohistochemistry highlights the T-cell lineage of this neoplasm (Fig 2).The diagnosis was consistent with extranodal peripheral T-cell lymphoma, unspecified (PTCL, u).Bone marrow biopsy revealed a normocellular marrow with trilineage hematopoiesis and no cytologic or morphologic evidence of lymphoma.Flow cytometry revealed no evidence of a clonal lymphoproliferative disorder.Antibodies to human immunodeficiency virus I/II and human T-cell lymphotrophic virus type I/II were negative.Lactate dehydrogenase was normal.Positron emission tomography (PET) imaging with [ 18 F]fluorodeoxyglucose (FDG) scan, however, demonstrated
Colorectal Cancer Screening on Stronger Footing
Authors: Robert H. Fletcher
Journal: New England Journal of Medicine (2008)

Screening for colorectal cancer has lagged behind other cancer screening, but it is now in a dynamic phase. New screening tests are available, and there is stronger evidence of their effectiveness. Screening rates in the United States have increased and are approaching the rates for long-established screening programs for breast and cervical cancer.1 The objective of screening has shifted from the early detection of cancers to prevention by means of detection and removal of adenomas, the precursors of most colorectal cancers.2 Two articles in this issue of the Journal move the field forward.3,4 Imperiale et al.3 studied the risk . . .
GA-binding protein (GABP) and Sp1 are required, along with retinoid receptors, to mediate retinoic acid responsiveness of CD18 (β2 leukocyte integrin): a novel mechanism of transcriptional regulation in myeloid cells
Authors: Thomas S. Bush, Michele St. Coeur, Karen K. Resendes, Alan G. Rosmarin
Journal: Blood (2002)
Fundamentals of Family Medicine
Authors: George L. Rainsford
Journal: JAMA (1983)

The need for a unique body of knowledge defined as family medicine is met in large measure by this textbook. To my knowledge, the information presented is not currently taught in the traditional medical school curriculum. The text is broad and diverse, as is the discipline of family medicine. Each chapter uniformly relates its information from the perspective of the family physician, thereby conveying that the most important therapeutic tool of family medicine is the family physician. This textbook of family medicine represents the collective work of over 60 authors, most of whom are recognized as leading spokesmen for family medicine. It is divided into major sections consisting of "Health Care for the Family," "Health and Illness Behavior," "Family Practice Approach: Physician Roles and Responsibilities," "Clinical Data Base: The Scope of Family Medicine," "Comprehensive and Continuous Care," "Patient Management Skills," "Diagnostic and Therapeutic Skills," and "Primary Care: Consultation and Referral."
Radiofrequency Catheter Ablation of Aberrant Conducting Pathways of the Heart
Authors: Joan Vatz
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Congenital Heart Disease among the Hutterite Brethren
Authors: Richard V. Lee, Richard S. Buker
Journal: New England Journal of Medicine (1969)

A FAMILY with four cases of tetralogy of Fallot was found in a distinct ethnic group, the Hutterite Brethren of North America. The customs and background of this religious sect provide an ideal population for retrospective and prospective genetic studies.The Hutterite Brethren1The Hutterite Brethren, located in agricultural colonies in the Great Plains states and Canadian provinces, originated in South Germany and the Tyrol about 1528. This is a communal movement with roots in the Anabaptist movement of the Reformation. The history is one of persecution because of religious and social beliefs and frequent migrations to more favorable political . . .
The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study
Authors: Gian Paolo Rossi, Maurizio Cesari, Mario Zanchetta, Stefania Colonna, Giuseppe Maiolino, Luigi Pedon, Martina Cavallin, Pietro Maiolino, Achille C Pessina
Journal: Journal of the American College of Cardiology (2003)
99mTc-HYNIC-TOC Imaging in the Evaluation of Pancreatic Masses Which are Potential Neuroendocrine Tumors
Authors: Zhen Qiao, Jingjing Zhang, Xiaona Jin, Li Huo, Zhaohui Zhu, Haiqun Xing, Fang Li
Journal: Clinical Nuclear Medicine (2015)

The aim of this investigation was to determine the accuracy of the findings and the diagnoses of Tc-hydrazinonicotinyl-Tyr3-octreotide scan (Tc-HYNIC-TOC imaging) in patients with pancreatic masses which were potential neuroendocrine tumors.Records of total 20 patients with pancreatic masses were retrospectively reviewed. All of the patients had been revealed by abdominal contrast CT and possibility of neuroendocrine tumors could not be excluded by CT imaging before Tc-HYNIC-TOC imaging. Tc-HYNIC-TOC imaging was performed at 1 and 4 hours post-tracer injection, and SPECT/CT images of the abdomen were also acquired. The image findings were compared to final diagnoses which were made from pathological examination.Among all 20 pancreatic masses evaluated, there were 16 malignant lesions which included 1 ductal adenocarcinoma and 15 neuroendocrine tumors. Tc-HYNIC-TOC imaging identified 14 of 15 pancreatic neuroendocrine tumors and excluded 4 of 5 lesions which were not neuroendocrine tumors. The overall sensitivity, specificity, and accuracy was therefore 93.3% (14 of 15), 80% (4 of 5), and 90.0% (18 of 20), respectively, in our patient population.Tc-HYNIC-TOC imaging provides reasonable accuracy in the evaluation pancreatic mass suspected to be neuroendocrine tumors.
920 CHOLESTASIS INCREASES THE RATE OF COMPLICATIONS AND ONE YEAR MORTALITY IN PATIENTS WITH HYPOXIC HEPATITIS
Authors: B. Jäger, A. Drolz, B. Michl, P. Schellongowski, A. Bojic, M. Nikfardjam, M. Wewalka, C. Zauner, G. Heinz, V. Fuhrmann
Journal: Journal of Hepatology (2011)