tbuckley/cabot-search huggingface dataset:
Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists.
Authors: S C Bischoff, T Brunner, A L De Weck, C A Dahinden
Journal: The Journal of Experimental Medicine (1990)

Human interleukin 5 (IL-5), known as a selective colony-stimulating factor of the eosinophil lineage and activator of mature eosinophils, also profoundly influences the mediator release profile of human basophils. IL-5 by itself triggers neither granule release nor de novo synthesis of lipid mediators. However, at low concentrations (0.1-10 ng/ml), IL-5 rapidly primes basophils for enhanced histamine release and leukotriene C4 (LTC4) generation in response to all established basophil agonists. LTC4 generation is more strongly affected by IL-5 than histamine release. In particular, IL-5 renders basophils capable of producing large quantities of LTC4 in response to C5a, which, without the cytokine, induces histamine release only. Finally, IL-5 renders basophils responsive to agonists (neutrophil-activating peptide 1 and C3a), which are otherwise inefficient triggers for basophil mediator release. The effects are similar to the recently established bioactivity of IL-3 on basophils, with the exception of its influence on IgE-dependent basophil activation, which is less pronounced. Thus, IL-5 strongly modulates the function not only of eosinophils but also of basophils, the two major effector leukocyte types involved in allergic inflammatory processes, e.g., in asthma.
Association Between Kidney Function and Albuminuria With Cardiovascular Events in HIV-Infected Persons
Authors: Andy I. Choi, Yongmei Li, Steven G. Deeks, Carl Grunfeld, Paul A. Volberding, Michael G. Shlipak
Journal: Circulation (2010)

Background— Cardiovascular disease (CVD) is now a leading cause of death in HIV-infected persons; however, risk markers for CVD are ill defined in this population. We examined the association between longitudinal measures of kidney function and albuminuria with risk of atherosclerotic CVD and heart failure in a contemporary cohort of HIV-infected individuals. Methods and Results— We followed a national sample of 17 264 HIV-infected persons receiving care in the Veterans Health Administration for (1) incident CVD, defined as coronary, cerebrovascular, or peripheral arterial disease, and (2) incident heart failure. Rates of CVD and heart failure were at least 6-fold greater in the highest-risk patients with an estimated glomerular filtration rate (eGFR) &lt;30 mL/min per 1.73 m 2 and albuminuria ≥300 mg/dL versus those with no evidence of kidney disease (eGFR ≥60 mL/min per 1.73 m 2 and no albuminuria). After multivariable adjustment, eGFR levels 45 to 59, 30 to 44, and &lt;30 mL/min per 1.73 m 2 were associated with hazard ratios for incident CVD of 1.46 (95% confidence interval, 1.15 to 1.86), 2.03 (1.47 to 2.82), and 1.99 (1.46 to 2.70) compared with eGFR ≥60 mL/min per 1.73 m 2 . Similarly, albuminuria levels 30, 100, and ≥300 mg/dL had hazard ratios for CVD of 1.28 (1.09 to 1.51), 1.48 (1.15 to 1.90), and 1.71 (1.30 to 2.27) compared with absent albuminuria. The associations between eGFR and albuminuria with heart failure were larger in magnitude and followed the same trends. Conclusions— In this national sample of HIV-infected persons, eGFR and albuminuria levels were strongly associated with risk of CVD and heart failure. Kidney function and albuminuria provide complementary prognostic information that may aid CVD risk stratification in HIV-infected persons.
Obstructive Uropathy Mimicking Volume Depletion-Reply
Authors: Wadi N. Suki
Journal: JAMA (1977)

<h3>In Reply.—</h3> Dr Salinger's observations are retrospective. While we concur that careful history-taking and integration of historical facts into the analysis of the case is one of the cornerstones of good medical practice, we question that he would have reached the diagnosis of obstructive uropathy sooner in either case, but particularly in the second. It is rewarding nevertheless that Dr Salinger did bother to read the case histories.
Diseases of Blood Vessels
Authors: David I. Abramson
Journal: JAMA (1985)

This is a multiauthored book, with 33 contributors, 21 of whom hold academic positions in the University of Pennsylvania School of Medicine; the three editors are also from the same institution. The main theme is disorders of blood vessels in many portions of the body, presented in 22 chapters. The unconventionally long and rambling preface deals first with an abbreviated and incomplete history of the highlights of diagnosis and treatment of vascular disorders of various types. This is followed by a second section, which consists of a listing of a large number of questions regarding the value of recent advances in diagnostic procedures, drug treatment, and therapeutic surgical procedures. Aside from a statement in the preface that these matters are considered, if not answered, in the contents, the editors have not clearly enunciated the purpose of the volume, nor are the segment or segments of the medical profession for which
P2-263: BCL-2, BCL-xL, Survivin and P53 protein expression and response to the chemotherapy with cisplatine and etoposide in non-small cell lung cancer
Authors: Bozenna Karczmarek-Borowska, Agata Filip, Kazimierz Gozdziuk, Andrzej Drop, Elzbieta Korobowicz, Jacek Wojcierowski, Dariusz Sagan
Journal: Journal of Thoracic Oncology (2007)
Intraoperative Measurements of Urinary Cyclic Amp to Guide Surgery for Primary Hyperparathyroidism
Authors: Allen M. Spiegel, Sarah T. Eastman, Maurice F. Attie, Robert W. Downs, Michael A. Levine, Stephen J. Marx, John L. Stock, Andrew W. Saxe, Murray F. Brennan, Gerald D. Aurbach
Journal: New England Journal of Medicine (1980)

SURGERY is the main form of therapy for primary hyperparathyroidism. The goal of therapy is to restore normal parathyroid function and avoid either persistent hyperfunction or permanent hypofunction. To achieve this goal the surgeon must remove an appropriate amount of hyperfunctioning tissue without injuring residual normal glands. At present the surgeon relies on gross and microscopical morphologic criteria in deciding which and how much parathyroid tissue to resect. Theoretically, intraoperative assessment of parathyroid function should help the surgeon to decide how much tissue to resect. We have previously shown1 that urinary cyclic AMP excretion, an accurate index of parathyroid function, . . .
Contaminants and Sea Ducks in Alaska and the Circumpolar Region
Authors: Charles J. Henny, Deborah D. Rudis, Thomas J. Roffe, Everett Robinson-Wilson
Journal: Environmental Health Perspectives (1995)

We review nesting sea duck population declines in Alaska during recent decades and explore the possibility that contaminants may be implicated. Aerial surveys of the surf scoter (Melanitta perspicillata), white-winged scoter (M. fusca), black scoter (M. nigra), oldsqaw (Clangula hyemalis), spectacled eider (Somateria fischeri), and Steller's eider (Polysticta stellei) show long-term breeding population declines, especially the latter three species. The spectacled eider was recently classified threatened under the Endangered Species Act. In addition, three other diving ducks, which commonly winter in coastal areas, have declined from unknown causes. Large die-offs of all three species of scoters during molt, a period of high energy demand, were documented in August 1990, 1991, and 1992 at coastal reefs in southeastern Alaska. There was no evidence of infectious diseases in those scoters. The die-offs may or may not be associated with the long-term declines. Many scoters had elevated renal concentrations of cadmium (high of 375 micrograms/g dry weight [dw]). Effects of cadmium in sea ducks are not well understood. Selenium concentrations in livers of nesting white-winged scoters were high; however, the eggs they laid contained less selenium than expected based on relationships for freshwater bird species. Histological evaluation found a high prevalence of hepatocellular vacuolation (49%), a degenerative change frequently associated with sublethal toxic insult. Cadmium and selenium mean liver concentrations were generally higher in those birds with more severe vacuolation; however, relationships were not statistically significant. We do not know if sea duck population declines are related to metals or other contaminants.
Mechanism of complement-mediated activation of human blood platelets in vitro: comparison of normal and paroxysmal nocturnal hemoglobinuria platelets.
Authors: R H Dixon, W F Rosse
Journal: Journal of Clinical Investigation (1977)

The paroxysmal nocturnal hemoglobinuria (PNH) platelet differs from the normal human platelet in its interaction with activated complement components: (a) when complement is activated by the alternative pathway, greater amounts of C3 are fixed to the PNH platelet than to the normal platelet; (b) the platelet-release reaction, as measured by serotonin release, occurs after C3 fixation to the PNH platelet. This reaction does not occur with normal platelets; (c) although serotonin release mediated by antibody alone was the same for normal and PNH platelets, antibody-initiated complement activation resulted in the fixation of greater amounts of C3 to PNH platelets and greater consequent serotonin release; and (d) nearly maximal serotonin release; and (d) nearly maximal serotonin release from PNH platelets occurs after the fixation of C3 (or perhaps C5) to the membrane without completion of the terminal sequence. In contrast, completion of the terminal complement sequence beyond C5 is required for maximal serotonin release from normal platelets. These abnormalities of interaction of complement components and PNH platelets may explain the occurrence of thromboses in this disease.
Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen
Authors: Innocent Safeukui, Jean-Michel Correas, Valentine Brousse, Déborah Hirt, Guillaume Deplaine, Sébastien Mulé, Mickael Lesurtel, Nicolas Goasguen, Alain Sauvanet, Anne Couvelard, Sophie Kerneis, Huot Khun, Inès Vigan-Womas, Catherine Ottone, Thierry Jo Molina, Jean-Marc Tréluyer, Odile Mercereau-Puijalon, Geneviève Milon, Peter H. David, Pierre A. Buffet
Journal: Blood (2008)
Collective Medical Nouns
Authors: J. M. ROCCA
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 February 1982Collective Medical NounsJ. M. ROCCA, M.B. B.S.J. M. ROCCA, M.B. B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-2-260_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I was interested to read Olans' contribution on medical collective nouns (1). I was vividly reminded of a series of similar terms that a fellow medical student and I invented, in a single session, a few years ago.We, too, thought of aclotof haematologists (and also agroup. . .) and acolonyof bacteriologists (who tend to be cultured people anyway). We also imagined awealthof surgeons; anorbitof ophthalmologists; acomplexof psychiatrists; acloneof geneticists; astreamof urologists; and acorpsof pathologists. Why not abrace...Reference1. OLANS R. A cast of nephrologists. Ann Intern Med. 1981;94:825. Ad libitum. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. M. ROCCA, M.B. B.S.Affiliations: Adelaide; South Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1982Volume 96, Issue 2 Page: 260-260 Keywords Pathologists Rivers Surgeons ePublished: 1 December 2008 Issue Published: 1 February 1982 PDF downloadLoading ...
Has Trench Fever Returned?
Authors: David A. Relman
Journal: New England Journal of Medicine (1995)

To those unfamiliar with the disease the man who has never been in the trenches cannot be suffering from trench fever, and for this reason the spread of the disease to new districts, and among those unfamiliar with its symptoms, will go unrecognised. . . . That trench fever might come amongst us is no idle supposition.— William Byam1 Although trench fever has probably been a part of human life for more than a thousand years, it was not until World War I that the disease came under intense scrutiny. In that war it afflicted approximately 1 million soldiers, . . .
Removing obstructed balloon catheter.
Authors: S C Sood, H Sahota
Journal: BMJ (1972)

usually refers to the destruction of the fetus per se.But as Dr. Wilkinson points out, many doctors conscientiously consider the needs of the whole person, allowing for the possibility that these needs may conflict with the patient's immediate demands.In my view these two issues are not distinct from each other; the destruction of the fetus must rarely be compatible with the whole patient's needs.If a woman (in one way way or another) procures an abortion, this indicates that we, as doctors, relatives, or citizens, have been failing to help her.-Iam, etc.,
The dual-mechanism model of inflectional morphology: A connectionist critique
Authors: Marc F. Joanisse, Todd R. Haskell
Journal: Behavioral and Brain Sciences (1999)

Clahsen has added to the body of evidence that, on average, regular and irregular inflected words behave differently. However, the dual-mechanism account he supports predicts a crisp distinction; the empirical data instead suggest a fuzzy one, more in line with single-mechanism connectionist models.
ASSESSMENT OF LEFT ATRIAL APPENDAGE WALL MOTION USING SPECKLE TRACKING TRANSESOPHAGEAL ECHOCARDIOGRAPHY IS USEFUL TO PREDICT THROMBUS FORMATION IN CHRONIC ATRIAL FIBRILLATION WITH WARFARIN THERAPY
Authors: Makoto Iwama, Ryuhei Tanaka, Shingo Minatoguchi, Shintaro Abe, Reiko Matsuoka, Yoshiaki Goto, Tomoko Fujii, Tai Kojima, Takeshi Hirose, Koji Ono, Shintaro Tanihata, Mami Iida, Toshiyuki Noda, Sachiro Watanabe, Takatomo Watanabe, Masanori Kawasaki, Shinya Minatoguchi
Journal: Journal of the American College of Cardiology (2012)
Prognostic significance of monitoring leukemia-associated immunophenotypes by eight-color flow cytometry in adult B-acute lymphoblastic leukemia
Authors: X-Q Weng, Y Shen, Y Sheng, B Chen, J-H Wang, J-M Li, J-Q Mi, Q-S Chen, Y-M Zhu, C-L Jiang, H Yan, X-X Zhang, T Huang, Z Zhu, Z Chen, S-J Chen
Journal: Blood Cancer Journal (2013)

Minimal residual disease (MRD) is of the most important factor for predicting prognosis and guiding treatment of acute lymphoblastic leukemia (ALL). In this study, we investigated the prognostic significance of leukemia-associated immunophenotypes (LAIPs) as assessment of index of MRD in 125 adult B-lineage ALL (B-ALL) patients by eight-color flow cytometry. The LAIPs could be identified in 96% and 81.6% of patients with the sensitivity of 10(-4) and 10(-5), respectively. MRD-negative status could clearly predict a favorable 2-year relapse-free survival (RFS) and overall survival (OS) at the end of induction of complete remission and one cycle of consolidation treatment. Moreover, we identified a group of cases with MRD of 0.001% to <0.01%, which showed significantly higher 2-year relapse rate than those with undetectable one. In multivariate analysis, MRD status was associated with RFS or OS independently. Furthermore, MRD assessed by LAIPs and RQ-PCR assay for patients with BCR-ABL fusion gene yielded concordant results in 89.7% of cases. In conclusion, MRD evaluated by eight-color flow cytometry could provide an important tool to assess treatment response and prognosis precisely in adult B-ALL.
Prison doctors: ethics, invisibility, and quality.
Authors: R Smith
Journal: BMJ (1984)

Smith addresses three areas of concern in his evaluation of prison health care in Britain: the ethical dilemmas faced by prison doctors, the isolation of these practitioners from the medical mainstream, and the quality of care rendered to prisoners. He concludes that prison doctors, who are employees of the Home Office rather than the National Health Service, are handicapped by the organization, invisibility, and lack of accountability of the prison medical system, and that closer cooperation and better communication with physicians outside the system would be beneficial.
Obtaining Tax-Exempt Status
Authors: Steven E. Seltzer
Journal: JAMA (1982)

<h3>To the Editor.—</h3> This letter describes the methods and pitfalls involved in obtaining tax-exempt status for a newly created medical educational organization. It is presented to facilitate the process for other physician educators. During the summer of 1981, the New England Computed Tomography Society was established. This organization was organized as a medical specialty society to foster interest and education in computed tomography among area radiologists. Contributions amounting to $200 were received from medical equipment and supply manufacturers to defray the Society's expenses-honoraria for guest speakers and publicity costs. To obtain tax-exempt status from the Internal Revenue Service (IRS), it was necessary to complete the 14-page Form 1023, "Application for Recognition of Exemption," in duplicate. It was also necessary to supply signed copies of the Society's "organizing instrument" (articles of association or constitution), bylaws, associated publications, promotional materials, and educational plan. The IRS publication No. 557, "How to Apply for
Role of transesophageal echocardiography in differentiating pannus from thrombus in obstructed prosthetic valves
Authors: J. Barbetseas, S.F. Nagueh, C. Pitsavos, P.K. Toutouzas, M.A. Quiñones, W.A. Zoghbi
Journal: Journal of the American College of Cardiology (1998)
Three-dimensional intravascular ultrasound imaging of arterial atherosclerosis and its complications: Improved recognition of the atheroma bulk, the span of dissection and intimal flaps, and the thrombus extent
Authors: K. Chandrasekaran, C.M. Sehgal, Tsui-Lieh Hsu, Sarah Katz, Andrew Weintraub, G. Mintz, Jonathan Elion, Alfred Parisi, Deeb Salem, Natesa Pandian
Journal: Journal of the American College of Cardiology (1991)
PRELIMINARY NOTE ON THE HISTOLOGY OF EGYPTIAN MUMMIES
Authors: M. A. Ruffer
Journal: BMJ (1909)

The fact that the arms and hands were more or less involved is distinctly in favour of strychnine.A point which was specially noticeable was that outside influences, noises, jars, movements of the bed, bright light, etc., had no effect whatsoever in causing or increasing the intensity of the spasms.Persistent Rigidity.The persistent rigidity and partial relaxation from time to time point strongly to a chronic variety of tetanus.
Online Systems for Searching MEDLINE
Authors: ANDREW G. FRANKS
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 March 1986Online Systems for Searching MEDLINEANDREW G. FRANKS JR., M.D.ANDREW G. FRANKS JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-441_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Haynes and colleagues (1) in the November issue contains information relevant to those considering an appropriate search system for the medical practice environment. As a user of the Knowledge Index system for the past year and a half, I want to point out an error in the authors' rating system that seriously and incorrectly negates the usefulness of this database.The authors state that searches on Knowledge Index could not be limited to the English-language articles, and therefore they diminished the direct relevance of the search. Clearly stated in the Knowledge Index workbook under...Reference1. HAYNESMCKIBBONWALKER RKC. Computer searching of the medical literature: an evaluation of MEDLINE searching systems. Ann Intern Med. 1985;103:812-6. LinkGoogle Scholar1. HAYNESMCKIBBONWALKER RKC. Computer searching of the medical literature: an evaluation of MEDLINE searching systems. Ann Intern Med. 1985;103:812-6. LinkGoogle Scholar1. HAYNESMCKIBBONWALKER RKC. Computer searching of the medical literature: an evaluation of MEDLINE searching systems. Ann Intern Med. 1985;103:812-6. LinkGoogle Scholar1. [Letter]. Knowledge Index News. 1985;3:9. Google Scholar1. HAYNESMCKIBBONWALKER RKC. Computer searching of the medical literature: an evaluation of MEDLINE searching systems. Ann Intern Med. 1985;103:812-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ANDREW G. FRANKSJR., M.D.Affiliations: 60 Gramercy Park North; New York, NY 10010 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPaperChase: For Medline searching 1 March 1986Volume 104, Issue 3Page: 441-443KeywordsDatabasesInformation technology ePublished: 1 December 2008 Issue Published: 1 March 1986 PDF downloadLoading ...
Diagnosis of Lipoid Pneumonia by Computed Tomography
Authors: Paul S. Wheeler, Frederick P. Stitik, Grover M. Hutchins, Harry F. Klinefelter, Stanley S. Siegelman
Journal: JAMA (1981)

Computed tomography (CT) can establish the diagnosis of lipoid pneumonia in lung masses by detecting fat. In this case report, the diagnosis of lipoid pneumonia was first suggested by CT, supported by a long history of mineral oil ingestion, and confirmed by needle aspiration biopsy of the larger of two lung lesions and specific stains. In the future, the detection of fat in lung masses by CT will warrant intermittent follow-up by routine chest x-ray films. Needle aspiration biopsy or surgery would be needed only if a mass showed signs of growth. (<i>JAMA</i>1981;245:65-66)