Hypothyroidism in Two Patients after Hepatic Arterial Chemoembolization
Authors: Nicholas A. Tritos, Keith Stuart, Pamela I. Hartzband
Journal: Annals of Internal Medicine (2001)

Letters20 March 2001Hypothyroidism in Two Patients after Hepatic Arterial ChemoembolizationNicholas A. Tritos, MD, DSc, Keith Stuart, MD, and Pamela I. Hartzband, MDNicholas A. Tritos, MD, DScBeth Israel Deaconess Medical Center; Boston, MA 02215 (Tritos, Stuart, Hartzband)Search for more papers by this author, Keith Stuart, MDBeth Israel Deaconess Medical Center; Boston, MA 02215 (Tritos, Stuart, Hartzband)Search for more papers by this author, and Pamela I. Hartzband, MDBeth Israel Deaconess Medical Center; Boston, MA 02215 (Tritos, Stuart, Hartzband)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-6-200103200-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We describe two patients who had not previously received thyroid therapy and became hypothyroid after arterial chemoembolization.A 66-year-old woman with metastatic carcinoid and a serum thyroid-stimulating hormone (TSH) level of 3.0 mIU/L (normal, 0.3 to 5.0 mIU/L) underwent hepatic arterial chemoembolization twice within 3 months. She developed clinical hypothyroidism 4 months after the first chemoembolization. Her serum TSH level was greater than 100 mIU/L, her serum thyroxine level was less than 19.3 nmol/L (normal, 64.4 to 154.5 nmol/L), and serum antimicrosomal antibodies were undetectable. A 58-year-old woman with metastatic adenocarcinoma and a serum TSH level of ...References1. Roti E, Vagenakis AG. Effect of excess iodide: clinical aspects.. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text. 7th ed. Philadelphia: Lippincott–Raven; 1996:316-27. Google Scholar2. Braverman LE, Ingbar SH, Vagenakis AG, Adams L, Maloof F. Enhanced susceptibility to iodide myxedema in patients with Hashimoto's disease. J Clin Endocrinol Metab. 1971;32:515-21. [PMID: 0004926257] CrossrefMedlineGoogle Scholar3. Braverman LE, Woeber KA, Ingbar SH. Induction of myxedema by iodide in patients euthyroid after radioiodine or surgical treatment of diffuse toxic goiter. N Engl J Med. 1969;281:816-21. [PMID: 000498022] CrossrefMedlineGoogle Scholar4. Wolff J, Chaikoff IL. The inhibitory action of excessive iodide upon the synthesis of diiodotyrosine and of thyroxine in the thyroid gland of the normal rat. Endocrinology. 1948;43:174-9. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Beth Israel Deaconess Medical Center; Boston, MA 02215 (Tritos, Stuart, Hartzband) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLiver-Directed Therapies for Colorectal MetastasesHypothyroidism in patients with hepatocellular carcinoma treated by transarterial chemoembolizationChemoembolization in the Management of Liver Tumors 20 March 2001Volume 134, Issue 6Page: 535KeywordsAdenocarcinomaAntibodiesHypothyroidismOilsThyroidThyroid diseasesThyroid hormonesThyroid-stimulating hormoneThyroxine ePublished: 20 March 2001 Issue Published: 20 March 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...