tbuckley/cabot-search huggingface dataset:
COMPARISON OF PREDICTIVE VALUE OF THE SPATIAL QRS-T ANGLE AND ITS VARIABILITY FOR RISK STRATIFICATION OF VENTRICULAR ARRHYTHMIA
Authors: Larisa Tereshchenko, Lichy Han, Alan Cheng, Joseph E. Marine, David Spragg, Sunil Sinha, Darshan Dalal, Hugh Calkins, Gordon F. Tomaselli, Ronald D. Berger
Journal: Journal of the American College of Cardiology (2011)
Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm
Authors: Stefan Fröhling, Richard F. Schlenk, Jochen Breitruck, Axel Benner, Sylvia Kreitmeier, Karen Tobis, Hartmut Döhner, Konstanze Döhner
Journal: Blood (2002)
The Motor Scooter
Authors: Edward D. Frank
Journal: New England Journal of Medicine (1964)

NOW that the academic year has begun college and medical-school students will once again be seen moving about the city on gay, little, economical motor scooters. Six or eight of these practical vehicles are parked in front of the Harvard Medical School dormitory at all times.As a staff surgeon of a general hospital in Boston I report the following incidents, all of which have occurred within recent memory.Case 1. A senior at Harvard College, an honor student in the humanities, was returning leisurely on his scooter from the airport when an unseen depression in the road bounced him . . .
The Electroencephalogram in Rheumatic Fever
Authors: Eugene F. Diamond
Journal: JAMA (1962)

SYDENHAM'S CLASSICAL DESCBIPTION of Chorea is now buried some 277 years in the archives of medical history, and yet the pathogenesis of chorea is still a matter of contention. The association of chorea and rheumatic fever was first described by Bright in 1831 and classical early endorsements of this association were added by Boger in 1868 and by Osier in 1887. From these earliest beginnings, however, there was a small but persistent minority who insisted on the primacy of nonrheumatic factors in the causation of chorea. The basis for this disagreement was the propensity of chorea to occur when the evidence for general rheumatic infection was absent. Because of this frequent lack of other clinical and laboratory evidence for rheumatic fever, chorea has been described as a "mild manifestation of rheumatic fever," a "late manifestation of rheumatic fever," a "major manifestation," and "the manifestation of rheumatic fever in the neurotic
Congenital methemoglobinemia caused by Hb‐M<sub>Ratnagiri</sub> (β‐63CAT→TAT, His→Tyr) in an Indian family
Authors: Prabhakar S. Kedar, Anita H. Nadkarni, Supriya Phanasgoankar, Manisha Madkaikar, Kanjaksha Ghosh, Ajit C. Gorakshakar, Roshan B. Colah, Dipika Mohanty
Journal: American Journal of Hematology (2005)

Abstract Hb‐M is a very rare hemoglobinopathy in the Indian subcontinent. We report a family with Hb‐M with lifelong cyanosis from the Ratnagiri district in western India. The propositus was a 11‐year‐old female child with a history of increasing cyanosis exacerbated by fever and weakness. Similar complaints were also noted in her mother and five maternal family members. There was no history of cardiac illness or exposure to drugs and chemicals. The methemoglobin level was 39.3% in the propositus and 21.1% in her mother with normal NADH‐methemoglobin reductase activity. Abnormal absorption peaks by spectroscopic analysis, presence of hemoglobin instability, and a slow‐moving band on starch gel electrophoresis supported the presence of Hb‐M. Automated DNA sequence analysis of the β globin gene showed a C→T substitution at codon 63. This leads to a substitution of histidine (CAT) by tyrosine (TAT) at the β 63 (E7) position, similar to Hb‐M Saskatoon. We have named this variant as Hb‐M Ratnagiri . Am. J. Hematol. 79:168–170, 2005. © 2005 Wiley‐Liss, Inc.
Smoking as a Cause of Erythrocytosis
Authors: ARTHUR L. SAGONE
Journal: Annals of Internal Medicine (1975)

Five smokers had erythrocyte masses sufficiently larger than normal to pose a problem in the differential diagnosis of polycythemia. Evaluation excluded lung disease, shunt physiology, hemoglobin with increased oxygen affinity, erythropoietin-producing tumor, renal disease, or polycythemia rubra vera as the primary cause of erythrocytosis in these patients. All were found to have levels of carboxyhemoglobin sufficient to cause clinically significant hypoxemia and to account for the increased erythrocyte masses. In two patients the erythrocytosis improved when they stopped smoking. Heavy smoking is a reversible cause of polycythemia and should be considered in the differential diagnosis of this problem.
Clinical Implications of Chronic Heart Failure Phenotypes Defined by Cluster Analysis
Authors: Tariq Ahmad, Michael J. Pencina, Phillip J. Schulte, Emily O’Brien, David J. Whellan, Ileana L. Piña, Dalane W. Kitzman, Kerry L. Lee, Christopher M. O’Connor, G. Michael Felker
Journal: Journal of the American College of Cardiology (2014)
Survey of general practitioners' prehospital management of suspected acute myocardial infarction
Authors: A Round, A J Marshall
Journal: BMJ (1994)

The effectiveness of thrombolysis in acute myocardial infarction is greater the shorter the time between onset of symptoms and administration of thrombolysis.1 Recent guidelines for the British Heart Foundation suggest that thrombolysis should be given within 90 minutes.2 Debate continues, however, about the best way to give thrombolysis and about the role of general practitioners.3,4 We studied general practitioners' knowledge of and attitudes and behaviour towards patients with suspected acute myocardial infarction and considered the relevance of our findings to the development of district policies.

Between June and August 1992 we sent a questionnaire to all general practitioners (n=205) who refer patients to Plymouth's coronary care unit, where all hospital thrombolysis for myocardial infarction in Plymouth district is given. The district is clearly divided into rural and urban areas, with 143 urban …
Five Years' Experience with Fluoridation in Norway, Maine
Authors: Alonzo H. Garcelon
Journal: New England Journal of Medicine (1959)

THE town of Norway, Maine, began fluoridating its water supply on October 17, 1952.An earlier report† presented evidence that beneficial effects began to become apparent in children six to nine years old within thirty months after fluoridation was started. During this period, the average numbers of decayed, missing and filled permanent teeth per child were reduced significantly, and the proportions of children entirely free of decay in permanent teeth were increased significantly. Similar experiences had been reported previously from Rio Vista, California, Coeur d'Alene and Lewiston, Idaho, Evanston, Illinois, New Jersey, Newburgh, New York, Marshall, Texas, and Sheboygan, Wisconsin. . . .
Diseases of Metabolism: Detailed Methods of Diagnosis and Treatment
Authors: Harold P. Schedl
Journal: JAMA (1961)

"Diseases of Metabolism," now in its fourth edition, is a reference work of proven merit. A wealth of basic scientific and practical knowledge is presented by distinguished contributors. The three classical divisions of metabolism, viz., carbohydrate, fat, and protein, are discussed in individual chapters. The remaining topics are mineral metabolism, water balance, vitamins and avitaminoses, undernutrition, obesity, glycogen storage disease and galactosemia, gout, porphyrin metabolism, spontaneous hypoglycemia, diabetes insipidus, melituria, diabetes mellitus, juvenile diabetes, thyroid disease, and kidney disease. It is inevitable for an undertaking of this magnitude to have errors, inconsistencies, and omissions. If brought to light, these can be corrected in future editions. These do not detract significantly from the merit of this textbook of medicine oriented toward metabolism. It is authoritative and useful.
Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells
Authors: R Jaster
Journal: Gut (2002)

Pancreatic stellate cells (PSCs) have been implicated in pancreatic fibrosis as they synthesise increased amounts of extracellular matrix proteins in response to activation by profibrogenic mediators such as cytokines.The purpose of this study was to analyse cytokine receptor stimulated signalling pathways involved in PSC activation. Using a rat culture model of PSCs, we have also tested the potential of the platelet derived growth factor (PDGF) antagonist trapidil and PD98059, a specific inhibitor of extracellular signal regulated kinase (ERK) activation, to suppress PSC growth.Cultured PSCs were stimulated with PDGF, and the signal transduction pathways activated in response to the mitogen were analysed by immunoblotting, kinase assays, and electrophoretic mobility shift assays. Furthermore, comparison of signalling cascades activated in PSCs before and after completing transdifferentiation to alpha-smooth muscle actin expressing myofibroblasts was performed. Biological effects of PDGF, trapidil, and PD98059 were analysed by proliferation assays and correlated with molecular effects of the substances.PDGF induced rapid activation of Raf-1, ERKs 1 and 2, as well as AP-1 proteins. The transforming growth factor beta activated transcription factor Smad2 was found to be constitutively phosphorylated in PSCs of different transdifferentiation grades. Furthermore, the results indicate a correlation between ERK activities and induction of PSC activation. Trapidil efficiently inhibited both PDGF induced ERK activation and, in common with PD98059, PSC proliferation.Our data suggest that ERKs play a key role in the regulation of PSC growth and that inhibition of the ERK signalling pathway may become a strategy to prevent activation of these cells.
Association of Risk-Reducing Surgery With Cancer Risks and Mortality in <emph type="ital">BRCA</emph> Mutation Carriers—Reply
Authors: Susan M. Domchek
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P92: Decreased Inotropic and Lusitropic Effects of Dobutamine on Post-cardiac Arrest Myocardial Dysfunction Under Hypothermia Treatment
Authors: Chien-Hua Huang, Min-Shan Tsai, Chiung-Yuan Hsu, Tzung-Dau Wang, Wei-Tien Chang, Wen-Jone Chen
Journal: Circulation (2009)
Phase 1 dose escalation of ONT-10, a therapeutic MUC1 vaccine, in patients with advanced cancer
Authors: John Nemunaitis, Cynthia Bedell, Kevin Klucher, Alex Vo, Sam Whiting
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Mucin 1 (MUC1), a glycoprotein normally expressed at low levels on the apical borders of secretory epithelial cells, is overexpressed and aberrantly glycosylated in many cancers. ONT 10 is a therapeutic peptide vaccine incorporating a synthetic glycolipopeptide MUC1 antigen,
Thermography in Diagnosis of Deep Venous Thrombosis
Authors: E. D. Cooke, M. F. Pilcher
Journal: BMJ (1973)

The possibility that subclinical increased heat of the limb may be an early and reliable sign in the diagnosis of deep venous thrombosis is being investigated using thermography. Of the 35 cases studied 17 have had early deep venous thrombosis confirmed on phlebography. Of these, 16 cases have been previously diagnosed using thermography.
Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0.
Authors: M Orho, N U Bosshard, N R Buist, R Gitzelmann, A Aynsley-Green, P Blümel, M C Gannon, F Q Nuttall, L C Groop
Journal: Journal of Clinical Investigation (1998)

Glycogen storage disease type 0 (GSD-0) is a rare form of fasting hypoglycemia presenting in infancy or early childhood and accompanied by high blood ketones and low alanine and lactate concentrations. Although feeding relieves symptoms, it often results in postprandial hyperglycemia and hyperlactatemia. The glycogen synthase (GS) activity has been low or immeasurable in liver biopsies, whereas the liver glycogen content has been only moderately decreased. To investigate whether mutations in the liver GS gene (GYS2) on chromosome 12p12.2 were involved in GSD-0, we determined the exon-intron structure of the GYS2 gene and examined nine affected children from five families for linkage of GSD-0 to the GYS2 gene. Mutation screening of the 16 GYS2 exons was done by single-strand conformational polymorphism (SSCP) and direct sequencing. Liver GS deficiency was diagnosed from liver biopsies (GS activity and glycogen content). GS activity in the liver of the affected children was extremely low or nil, resulting in subnormal glycogen content. After suggestive linkage to the GYS2 gene had been established (LOD score = 2.9; P < 0.01), mutation screening revealed several different mutations in these families, including a premature stop codon in exon 5 (Arg246X), a 5'-donor splice site mutation in intron 6 (G+1T--> CT), and missense mutations Asn39Ser, Ala339Pro, His446Asp, Pro479Gln, Ser483Pro, and Met491Arg. Seven of the affected children carried mutations on both alleles. The mutations could not be found in 200 healthy persons. Expression of the mutated enzymes in COS7 cells indicated severely impaired GS activity. In conclusion, the results demonstrate that GSD-0 is caused by different mutations in the GYS2 gene.
The New Seduction
Authors: Robert H. Moser
Journal: JAMA (1974)

In an earlier communication (<i>JAMA</i>227:1045, 1974) Weldon J. Walker reported the very real declining incidence of death from ischemic heart disease that has occurred in the United States since 1963. The Surgeon General's Report on Smoking and Health (1964) appeared to be the watershed—relating cigarette smoking to the increasing morbidity and mortality from coronary artery disease, chronic obstructive lung disease, peptic ulcer, and bronchial carcinoma. Well, it would seem that except for the latter disease, all others have declined since then. And this happy revelation can be correlated with less cigarette smoking and improved dietary habits (lower caloric consumption and less ingestion of saturated fats) by many Americans in the vulnerable age groups. Elsewhere in this issue (page 1529), Walker takes up his battered lance once again to demand an end to federal subsidies, loans, and tax breaks to industries that support cigarette production. He believes that it is
TOTAL AND SUBTOTAL RESTORATION OF THE NOSE
Authors: VILRAY P. BLAIR
Journal: JAMA (1925)

To be acceptable, a surgically reconstructed nose must be covered with smooth skin, have a normal contour, have an epithelial lining, and provide an adequate airway. Though not always necessary, a rigid support of bone or cartilage will usually add to the quality of the result (Figs. 1 and 2). It is very desirable that the size and form of the new nose be in harmony with the particular face. Nasal reconstruction amounts to sculpturing with the live tissues for material, and this must be done in conformity with good surgical usage, combined with mechanical accuracy and some artistic feeling (Fig. 3). Phidias seems to have been unique among sculptors in his ability to make a free hand carving of his ideal without previously working it out in some plastic material, and there are probably few surgeons of sufficient skill to emulate Phidias' example. Even a tailor will make a pattern
Canadian doctors say it is inappropriate for them to prescribe marijuana
Authors: C. Santry
Journal: BMJ (2012)

Canadian doctors have rejected plans to allow them to write marijuana “prescriptions” and provide the drug directly to patients.

The federal government proposes transferring the responsibility for prescribing marijuana from the public health agency Health Canada to individual doctors in March 2014. But medical associations have warned that the proposals could have adverse consequences for doctors and patients.

The Federation of Medical Regulatory Authorities of Canada and the Canadian Medical Association have voiced their concerns in a letter to the health minister, Leona Aglukkaq.

It states, “At present, given the lack of scientific-based evidence of the product, there is insufficient information on correct dosage, specifics of patient monitoring and measures of efficacy, possible side effects and interaction with other medications or pre-existing conditions.”

The federation’s president, Heidi Oetter, …
The quality of reports of randomised trials in 2000 and 2006: comparative study of articles indexed in PubMed
Authors: S. Hopewell, S. Dutton, L.-M. Yu, A.-W. Chan, D. G Altman
Journal: BMJ (2010)

<b>Objectives</b> To examine the reporting characteristics and methodological details of randomised trials indexed in PubMed in 2000 and 2006 and assess whether the quality of reporting has improved after publication of the Consolidated Standards of Reporting Trials (CONSORT) Statement in 2001. <b>Design</b> Comparison of two cross sectional investigations. <b>Study sample</b> All primary reports of randomised trials indexed in PubMed in December 2000 (n=519) and December 2006 (n=616), including parallel group, crossover, cluster, factorial, and split body study designs. <b>Main outcome measures</b> The proportion of general and methodological items reported, stratified by year and study design. Risk ratios with 95% confidence intervals were calculated to represent changes in reporting between 2000 and 2006. <b>Results</b> The majority of trials were two arm (379/519 (73%) in 2000 <i>v</i> 468/616 (76%) in 2006) parallel group studies (383/519 (74%) <i>v</i> 477/616 (78%)) published in specialty journals (482/519 (93%) <i>v</i> 555/616 (90%)). In both 2000 and 2006, a median of 80 participants were recruited per trial for parallel group trials. The proportion of articles that reported drug trials decreased between 2000 and 2006 (from 393/519 (76%) to 356/616 (58%)), whereas the proportion of surgery trials increased (51/519 (10%) <i>v</i> 128/616 (21%)). There was an increase between 2000 and 2006 in the proportion of trial reports that included details of the primary outcome (risk ratio (RR) 1.18, 95% CI 1.04 to 1.33), sample size calculation (RR 1.66, 95% CI 1.40 to 1.95), and the methods of random sequence generation (RR 1.62, 95% CI 1.32 to 1.97) and allocation concealment (RR 1.40, 95% CI 1.11 to 1.76). There was no difference in the proportion of trials that provided specific details on who was blinded (RR 0.91, 95% CI 0.75 to 1.10). <b>Conclusions</b> Reporting of several important aspects of trial methods improved between 2000 and 2006; however, the quality of reporting remains well below an acceptable level. Without complete and transparent reporting of how a trial was designed and conducted, it is difficult for readers to assess its conduct and validity.
F-18 FDG Uptake by Recurrent Hürthle Cell Carcinoma of the Thyroid Using High-Energy Planar Scintigraphy
Authors: CYNTHIA L. BLOUNT, HOWARD J. DWORKIN
Journal: Clinical Nuclear Medicine (1996)

F-18-2-deoxy-2-fluoro-D-glucose (FDG) has been reported to localize in various tumors. Localization of recurrent Hürthle cell cancer with FDG is described. An unsuccessful attempt was made to image this patient's tumor with I-131 and Tc-99m MIBI. Because of the patient's size, he could not be accommodated in the PET camera apperature. Use of a planar high energy gamma camera facilitated detection and ultimate treatment.
Antiretroviral Therapy for Children
Authors: Joseph I. Harwell, Stephen K. Obaro
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Retrospective Clinical Study of Pulmonary Disease Due to "Anonymous Mycobacteria" in Wales
Authors: S. R. Kamat, C. E. Rossiter, J. C. Gilson
Journal: Thorax (1961)

As tuberculosis decreases in frequency, more attention is being given to other bacteria causing similar chronic granulomatous lesions in the lung.In the last 10 years lesions attributed to " anonymous mycobacteria " have been frequently discussed.Such organisms were isolated in occasional cases from the sputum, gastric wash- ings, or pleural fluid of patients with pulmonary disease before the era of chemotherapy (Branch,
Cryptococcosis of the Anterior Segment in Acquired Immune Deficiency Syndrome
Authors: Norman C. Charles, Cynthia A. Boxrud, Elizabeth A. Small
Journal: Ophthalmology (1992)

Cryptococcosis is a rare form of human ocular infection, usually occurring in immunocompromised patients. Unilateral or bilateral posterior segment involvement is the rule. The authors describe a unique case of intraocular cryptococcosis presenting as an iris inflammatory mass in a patient with acquired immune deficiency syndrome. Diagnosis was established by anterior chamber paracentesis and confirmed by histopathologic examination of the enucleated eye. Cryptococcosis is a rare form of human ocular infection, usually occurring in immunocompromised patients. Unilateral or bilateral posterior segment involvement is the rule. The authors describe a unique case of intraocular cryptococcosis presenting as an iris inflammatory mass in a patient with acquired immune deficiency syndrome. Diagnosis was established by anterior chamber paracentesis and confirmed by histopathologic examination of the enucleated eye.