tbuckley/cabot-search huggingface dataset:
Immunoscintigraphic Localization in a Benign Thyroid Neoplasm of a Monoclonal Antibody Directed against Melanoma
Authors: LUCIANO FEGGI, NAPOLEONE PRANDINI, GIANCARLO PANSINI, TIZIANA VIRGILI, MONICA INDELLI, ANNA ROSA VIRGILI
Journal: Clinical Nuclear Medicine (1991)

In a prospective study for evaluation of the use of a monoclonal antibody directed against melanoma in the staging of patients affected by malignant melanoma, we report monoclonal antibody uptake in a follicular thyroid adenoma. Computed tomography, ultrasonography, and pertechnetate scintigraphy did not provide a certain diagnosis. Only pathologic examination of the surgical specimen was conclusive.
Maternal Exposure to Potential Teratogens
Authors: Robert C. Goodlin
Journal: JAMA (1968)

<h3>To the Editor:—</h3> As an obstetrician, I have read with interest the paper of Nora et al, "Maternal Exposure to Potential Teratogens" (<b>202</b>: 1065, 1967). I believe the paper poses several questions, the first being the criteria used by the authors for the selection of "potential" teratogens. Since the apparent criteria were "hazards known to be or suspected of being teratogenic to man or other species," I wonder why their list did not include such "potential" teratogens as cosmic rays, high altitudes, emotional upsets, inadequate diets, amplified sounds, etc? Indeed, a list of agents which are not "potential" teratogens would be most useful to obstetricians. Despite the fact that the authors' data failed to demonstrate a positive correlation between "teratogens" and major anomalies, they still have admonished physicians to decrease the exposure of pregnant women to drugs. Since I assume that all of the drugs prescribed in the authors' study
Differential Diagnosis of Mucin-Producing Tumors of the Pancreas by Intraductal Ultrasonography and Peroral Pancreatoscopy
Authors: H. Mukai, K. Yasuda, M. Nakajima
Journal: Endoscopy (1998)

Background and Study Aims: Although mucin producing tumors of the pancreas have been recently recognized as premalignant or malignant neoplasms, their diagnosis and management have been undetermined as yet. The aim of this study was to evaluate the capability of intraductal ultrasonography (IDUS) and peroral pancreatoscopy (PPS) in the differential diagnosis of mucin-producing tumors compared to that of other diagnostic tools.
Exercise-induced abnormal blood pressure responses are related to subendocardial ischemia in hypertrophic cardiomyopathy
Authors: Noriko Yoshida, Hisao Ikeda, Toyofumi Wada, Akira Matsumoto, Sanae Maki, Aiko Muro, Akira Shibata, Tsutomu Imaizumi
Journal: Journal of the American College of Cardiology (1998)
STUDIES ON THE INTERACTION BETWEEN PHAGOCYTES AND TUBERCLE BACILLI
Authors: Hartmann Stähelin, Manfred L. Karnovsky, Emanuel Suter
Journal: The Journal of Experimental Medicine (1956)

Tubercle bacilli labelled with C(14) were prepared by growth on radioactive substrates such as glycerol, CO(2), and acetate. These organisms were exposed in vitro to leucocytes (mostly polymorphonuclear leucocytes) from peritoneal exudates of guinea pigs. The respiration of the leucocytes and of the bacilli, alone and together, was followed by determining oxygen uptake and C(14)O(2) production. When heat-killed labelled tubercle bacilli were exposed to leucocytes there was little or no degradation of bacillary material to C(14)O(2) by leucocytic enzymes. On the other hand, conversion of components of sonically disrupted bacilli to C(14)O(2) by leucocytes was significant. It was possible to determine the oxygen uptake and C(14)O(2) production of phagocytized living tubercle bacilli, and it was found that after phagocytosis the bacilli maintained their rates of oxygen consumption and C(14)O(2) production. This finding was in contrast to observations made with Mycobacterium phlei, a saprophytic acid-fast organism, and with Bacillus subtilis. In these cases oxygen consumption and C(14)O(2) production declined after phagocytosis, and bacterial components were converted to carbon dioxide to a significant degree by leucocytic enzymes.
Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP
Authors: T. Kobayashi
Journal: Journal of Clinical Investigation (2005)

In the developing growth plate, periarticular chondrocytes proliferate, differentiate into columnar chondrocytes, and then further differentiate into postmitotic hypertrophic chondrocytes. Parathyroid hormone–related (PTH-related) protein (PTHrP), regulated by Indian hedgehog (Ihh), prevents premature hypertrophic differentiation, thereby maintaining the length of columns. Ihh regulates cartilage development through PTHrP-independent pathways as well. Here we show that Ihh stimulates differentiation of periarticular to columnar chondrocytes (periarticular chondrocyte differentiation) and thereby regulates the length of columns independently of PTHrP. Mosaic ablation of the PTH/PTHrP receptor in the growth plate caused upregulation of Ihh action, PTHrP upregulation, acceleration of periarticular chondrocyte differentiation, and elongation of the columnar region. Decreasing Ihh action in these mice reduced elongation of columns, whereas decreasing PTHrP showed only a modest effect on column length. Overexpression of Ihh caused PTHrP upregulation, elongation of columns, and acceleration of periarticular chondrocyte differentiation. PTHrP heterozygosity in this model had a minimal effect on the elongation of columns. Moreover, the elongation of columns and stimulation of periarticular chondrocyte differentiation in these models were still observed when PTHrP signaling was maintained so that it remained constant. These results demonstrate that Ihh acts on periarticular chondrocytes to stimulate their differentiation, thereby regulating the columnar cell mass independently of PTHrP.
Adjuvanted or whole-virion vaccine for 2009 influenza A (H1N1) – Authors' reply
Authors: Katja Hoschler, Maria Zambon, Karl G Nicholson
Journal: The Lancet Infectious Diseases (2011)

We recognise that the sensitivity of the haemagglutination-inhibition assay is crucial to manufacturers. We were careful to avoid issues of assay technical performance that might produce specious differences in the serum analysis in our study.1 The laboratory was masked to vaccine allocation and analysed all serum samples with identical protocols. Samples from each patient were assayed together, and masked serological data were released to an independent statistician holding the randomisation codes.
THE DIAGNOSIS AND THERAPY OF HEALTH
Authors: ABRAM BLAU
Journal: American Journal of Psychiatry (1954)

Dynamically, health is the phase of the life process characterized by relatively efficient and stable homeostatic balance of vital forces. It consists of a minimum of maladjustment within the individual and in his relation to society and physical environment, a capacity for ready recovery from disturbances, and a fair assurance of the continuation of the stability. However, its evaluation is relative and varies according to the perspective of the individual, the physician, or society. Descriptively, the concept of health is synonymous with those of personality or constitution. Traits are also its unit features. A pathology of health is a valid view and refers to defects and limitations. The therapy of health is concerned with the maintenance of health, the alleviation and improvement of defects, the forestalling of disturbance of health by disease and the protection of community health. An adequate nosology requires a paired diagnosis including the basic health (constitution or personality) of the individual in addition to the active disease process so that treatment can be properly focused on each.
Radiation Exposure From Outpatient Radioactive Iodine (&lt;SUP&gt;131&lt;/SUP&gt;I) Therapy for Thyroid Carcinoma
Authors: Perry W. Grigsby
Journal: JAMA (2000)

In May 1997, the US Nuclear Regulatory Commission (NRC) revised its patient release regulations, allowing for outpatient administration of larger activities of sodium iodide 131I than previously permitted.To measure the radiation exposure to household members from patients receiving outpatient 131I therapy for thyroid carcinoma in accordance with the new regulations.Consecutive case series from October 1998 to June 1999.Thirty patients who received outpatient 131I therapy following thyroidectomy for differentiated thyroid carcinoma were enrolled, along with their 65 household members and 17 household pets.Radiation exposure to household members and 4 rooms in each home, as monitored with dosimeters for 10 days following 131I administration.The patients received 131I doses ranging from 2.8 to 5.6 GBq (mean, 4.3 GBq). The radiation dose to 65 household members ranged from 0.01 mSv to 1.09 mSv (mean, 0.24 mSv). The dose to 17 household pets ranged from 0.02 mSv to 1.11 mSv (mean, 0.37 mSv). The mean dose to the 4 rooms ranged from 0.17 mSv (kitchen) to 0.58 mSv (bedroom).In our study, 131I doses to household members of patients receiving outpatient 131I therapy were well below the limit (5.0 mSv) mandated by current NRC regulations.
Sullivan Criticizes Company For Courting Smokers At Tennis Matches
Authors: K. Broder
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Sullivan Criticizes Company For Courting Smokers At Tennis Matches Get access Karen Broder Karen Broder Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 7, 4 April 1990, Pages 551–552, https://doi.org/10.1093/jnci/82.7.551 Published: 04 April 1990
"CONNECTICUT INVESTIGATION OF MEDICAL DIPLOMA SCANDAL"
Authors: William P. Best
Journal: JAMA (1923)

To the Editor:  —InThe Journal, November 10, you refer to the  medical (?) school of Kansas City as Eclectic. The Alexander school is not and never was Eclectic, and does not claim to be such except in a very dishonest roundabout way to deceive a few who may be influenced by such claim.  Dr. Alexander of Kansas City, Mo., is not a member of the National Eclectic Medical Association, nor of the Missouri State Eclectic Medical Society, nor has he been since at Nashville, Tenn., the National Eclectic Medical Association refused to recognize his school in 1917.  The action of the so-called Eclectic Boards we deplore because they are a discredit to the profession in general and to Eclectics in particular.  We have no way of controlling the action of the legislatures of states wherein separate boards represent the various systems of practice.  Every effort was made use of
Scientific and Legal Viability of Follow-on Protein Drugs
Authors: David M. Dudzinski, Aaron S. Kesselheim
Journal: New England Journal of Medicine (2008)

Many recombinant-protein drugs such as erythropoietin are now off patent, and the availability of generic versions of these drugs would reduce costs. The federal laws that simplify and expedite approval of generic forms of other drugs do not apply to recombinant-protein drugs. Congress is developing legislation to facilitate the approval of follow-on protein drugs.
Alkaline Phosphatase and Hyperthyroidism
Authors: D. G. OREOPOULOS
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 May 1979Alkaline Phosphatase and HyperthyroidismD. G. OREOPOULOS, M.D., PH.D.D. G. OREOPOULOS, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-5-854_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Cooper and colleagues mention in their recent article "Alkaline Phosphatase Isoenzyme Patterns in Hyperthyroidism" in the February issue (1), that "bone healing in patients with hyperthyroidism may take a prolonged period"; they also observed that "serum alkaline phosphatase may not return to normal for 18 to 24 months after treatment." Further, they mention that the enzyme pattern of alkaline phosphatase from normal before treatment converts to predominant bone in origin after treatment.Velentzas and colleagues (2) have shown that patients with hyperthyroidism have significantly lower plasma levels of 25 hydroxy-vitamin D than do normal controls subjects....References1. COOPERKAPLANRIDGWAYMALOOFDANIELS DMEFG: Alkaline phosphatase isoenzyme patterns in hyperthyroidism. Ann Intern Med 90:164-168, 1979 LinkGoogle Scholar2. VELENTZASOREOPOULOSFROMPORRETRAPOPORT CDGBA: Vitamin-D levels in thyrotoxicosis (letter). Lancet 1:370-371, 1977 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: D. G. OREOPOULOS, M.D., PH.D.Affiliations: Toronto Western Hospital Toronto, ON M5T 2S8, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1979Volume 90, Issue 5Page: 854-854KeywordsBlood plasmaBoneEnzymesHyperthyroidismPhosphatases ePublished: 1 December 2008 Issue Published: 1 May 1979 PDF downloadLoading ...
Dysmorphology of Cilia
Authors: Harry B. Neustein, Joseph Church, Seymour Cohen
Journal: JAMA (1979)

RECENTLY attention has been called to a small group of patients who were sterile, who had chronic lung disease, and whose sperm tails and respiratory tract cilia were abnormal when examined by electron microscopy.<sup>1,2</sup>Cilia showed an absence of dynein arms, which contain adenosine triphosphatase (ATPase), and thus account for the lack of movement of the cilia. This absence of dynein arms (ATPase) was considered to be hereditary.<sup>1</sup>Additional reports have noted abnormal cilia from the respiratory tracts of patients with several diseases of the lung.<sup>3,4</sup>These descriptions led us to examine mucosa of the respiratory tract in selected patients with chronic lung disease. In one such patient with normal immunologic function, a bizarre morphological condition of cilia was found. <h3>Report of a Case</h3> An 8-year-old boy had chronic suppurative respiratory disease, which had its onset at age 1 month. He also had chronic purulent otitis media
Treatment of Graves' Disease
Authors: Peter H. Gott
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Thomason and Nusynowitz (242:2437, 1979) in an editorial, "Thionamides for Hyperthyroidism: On a Clear Day You Can Treat Forever," admirably summarized the risks and advantages of drug treatment for hyperthyroidism. Inasmuch as the effects of iodine 131 therapy and surgery are relatively permanent, the clinician must be cautious in recommending such therapies in the presence of exophthalmos. Occasionally, the eye manifestations of Graves' disease may worsen during or after control of the primary thyroid problem. I advise thionamide therapy for patients with exophthalmos because, by using medication, the physician can closely regulate treatment. If a patient's eyes worsen during thionamide administration, appropriate options—such as dose reduction or use of steroids—can be used without the physician being committed to a single irreversible course of therapy. On the other hand, if after two to three months of treatment, the exophthalmos is stable or regressing, definite treatment may be considered. By
Blocking activity to action of thyroid stimulating hormone in serum from patients with primary hypothyroidism.
Authors: N R Steel, D R Weightman, J J Taylor, P Kendall-Taylor
Journal: BMJ (1984)

Spontaneous primary hypothyroidism in adults is usually associated with autoimmune thyroiditis. The hypothesis that hypothyroidism may result from the presence in serum of a factor that blocks stimulation of the thyroid by thyroid stimulating hormone was examined. Serum samples were collected from 28 patients with recently diagnosed primary hypothyroidism. After removal of endogenous thyroid stimulating hormone the effect of the serum on secretion of triiodothyronine induced by thyroid stimulating hormone or thyroid stimulating antibodies was examined in thyroid slices incubated in vitro. Serum samples from six of the patients demonstrated significant blocking of the stimulation by bovine thyroid stimulating hormone. Inhibition of the stimulatory action of thyroid stimulating antibodies was also exhibited by serum samples with blocking activity. It is concluded that in some patients with primary hypothyroidism a serum factor, which is probably an IgG, exists that can block the thyroid response to thyroid stimulating hormone and thyroid stimulating antibodies; it may represent an important mechanism in the pathogenesis of hypothyroidism.
ON PSYCHO-ANALYSIS
Authors: D. Forsyth
Journal: BMJ (1913)

TTHE past few yenrs have been uncommonly fruitful in psychological research of use in clinical practice, more especially in enriching our meagre store of methlods of investigating and treating many of the everyday cases of psychical disorders.It is to one of the most helpful of these methods that these two lectures will be devoted.To begin with, it may be recalled that these disorders have been classified as (1] psycho-neuroses, (2) neuroses, and (3) psychoses.The first named never have any but psychical origiins-perhaps long since passed out of mindand tlleir symptoms are the end links of an unbroken psychological chain stretching back to the starting point.They are, from first to last, exclusively psychical, and can be cured only by tracing the cause and removing it like a foreign body from the mind.With the neuroses, on the -other hand, the primary cause is physical, the symptoms lasting only so long as the cause continues to act, and, needless to say, they cannot be remedied by psychical methods alone; to this group belongs, among others, meurasthenia.Lastly, the psychoses result from toxic influences on the brain matter, the best known being the polyneuritic psychosis (Korsakoff's psychosis) associated -with alcoholic periplheral neuritis.As the psycho-neuroses alone are of interest to us here, the only additional specification that -need be made is that this class is itself -divided into three clinical groups- hysterias, phobies (horrors and uncontrollable fears), and 'obsessions (fixed ideas).With this outline in our minds, it goes without saying that psycho-neuroses are not to be treated without an understanding of psychology, that is, of the science which, *to quote the definition of the term, is concerned with "the nature, functions, and phenomena of the human soul or wmind."The clinician, therefore, w-ho proposes to treat psycho-neurotic patients must base his work on a deeper insight into the human mind than is afforded by the ex- perim-ental psyChology which deals with sensory stimui, motor reactions, and the like.And, in contemplating this departure, he need not hesitate for fear of being drawn into metaphysical or theological speculation; on the con- trary, he will find no occasion to move outside the firm ground of practical medicine.Nevertheless, every new development in science, while its facts are as yet few, stands in need of a working hypothesis to help it to further observations.As to what hypothetical conception of the mechanism of the human mind will best serve psychology in th6 long run opinion is likely to differ, but, thanks to Professor Freud, one is already to band which has proved itself at once a key to the nature of many psychical disorders and a gtuide to their cure.This work of Freud's, or, rather, that part of it on whiC11 is based the clinical method of psycho-analysis, Nvill now be considered, any apparent dogmatism of state- ment in the following account being attributed, it is hoped, to the necessity of compressing a large subject within the 1imits of a lecture.
Anterior Mitral Leaflet Curvature During the Cardiac Cycle in the Normal Ovine Heart
Authors: John-Peder Escobar Kvitting, Wolfgang Bothe, Serdar Göktepe, Manuel K. Rausch, Julia C. Swanson, Ellen Kuhl, Neil B. Ingels, D. Craig Miller
Journal: Circulation (2010)

The dynamic changes of anterior mitral leaflet (AML) curvature are of primary importance for optimal left ventricular filling and emptying but are incompletely characterized.Sixteen radiopaque markers were sutured to the AML in 11 sheep, and 4-dimensional marker coordinates were acquired with biplane videofluoroscopy. A surface subdivision algorithm was applied to compute the curvature across the AML at midsystole and at maximal valve opening. Septal-lateral (SL) and commissure-commissure (CC) curvature profiles were calculated along the SL AML meridian (M(SL))and CC AML meridian (M(CC)), respectively, with positive curvature being concave toward the left atrium. At midsystole, the M(SL) was concave near the mitral annulus, turned from concave to convex across the belly, and was convex along the free edge. At maximal valve opening, the M(SL) was flat near the annulus, turned from slightly concave to convex across the belly, and flattened toward the free edge. In contrast, the M(CC) was concave near both commissures and convex at the belly at midsystole but convex near both commissures and concave at the belly at maximal valve opening.While the SL curvature of the AML along the M(SL) is similar across the belly region at midsystole and early diastole, the CC curvature of the AML along the M(CC) flips, with the belly being convex to the left atrium at midsystole and concave at maximal valve opening. These curvature orientations suggest optimal left ventricular inflow and outflow shapes of the AML and should be preserved during catheter or surgical interventions.
Adenosine deaminase activity in chronic lymphocytic leukemia. Relationship to B- and T-cell subpopulations.
Authors: R Tung, R Silber, F Quagliata, M Conklyn, J Gottesman, R Hirschhorn
Journal: Journal of Clinical Investigation (1976)

The level, phenotypes, and isozyme distribution of adenosine deaminase (ADA) were determined in lymphocytes from patients with chronic lymphocytic leukemia (CLL). The ADA level in lymphocytes from patients with untreated CLL was consistently lower than in lymphocytes from normal subjects. No significant differences were found in the phenotype or isozyme distribution. In untreated patients, the ADA level was inversely correlated with the lymphocyte count and the percentage of bursa-equivalent (B) cells. After therapy, a diminution in the lymphocyte count was associated with an increase of ADA activity towards normal levels. The ADA levels were slightly higher in the thymus-derived (T) than in the B lymphocytes from normal subjects. The B cells had lower activity than T cells in patients with CLL. They also had a lower activity than the B cells from normal subjects. The ADA level was 2.3-fold higher in T cells from patients with CLL than in normal T cells. The decrease in ADA levels is an anomaly that is reversible and appears to be a reflection of the proliferation of abnormal B cells in this disorder.