Nodular Non-Hodgkin's Lymphoma: The Case for Watchful Waiting
Authors: BRUCE A. CHABNER
Journal: Annals of Internal Medicine (1979)

Editorials1 January 1979Nodular Non-Hodgkin's Lymphoma: The Case for Watchful WaitingBRUCE A. CHABNER, M.D.BRUCE A. CHABNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-115 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis issue carries an unusual and provocative article (pp. 10-13) by Portlock and Rosenberg describing their experience with a "hands-off therapeutic approach to selected patients with good-prognosis forms of non-Hodgkin's lymphoma. Their article analyzes a 15-year experience with 44 patients in whom therapy was withheld until necessitated by progression of disease; this study contrasts with the general trend of clinical research in non-Hodgkin's lymphoma, which in recent years has been concerned with the application of intensive, and possibly curative, therapy at the time of diagnosis.The importance of this article, and indeed the debate over "good prognosis" non-Hodgkin's lymphoma, can...References1. RAPPAPORTWINTERHICKS HWE: Follicular lymphoma. A reevaluation of its position in the scheme of malignant lymphomas, based on a survey of 253 cases. Cancer 9:792-821, 1956 CrossrefMedlineGoogle Scholar2. CHABNERJOHNSONYOUNGCANELLOSHUBBARDJOHNSONDEVITA BRRGSSV: Sequential nonsurgical and surgical staging of non-Hodgkin's lymphoma. Ann Intern Med 85:149-154, 1976 LinkGoogle Scholar3. ANDERSONBENDERFISHERDEVITACHABNERBERARDNORTONYOUNG TRRVBCLR: Combination chemotherapy in non-Hodgkin's lymphoma: results of long-term followup. Cancer Treat Rep 61:1057-1066, 1977 MedlineGoogle Scholar4. DEVITACANELLOSCHABNERSCHEINHUBBARDYOUNG VGBPSR: Advanced diffuse histiocytic lymphoma, a potentially curable disease. Results with combination chemotherapy. Lancet 1:248-249, 1975 CrossrefMedlineGoogle Scholar5. YOUNGJOHNSONCANELLOSCHABNERBRERETONBERARDDEVITA RRGBHCV: Advanced lymphocytic lymphoma: randomized comparisons of chemotherapy and radiotherapy, alone or in combination. Cancer Treat Rep 61:1153-1159, 1977 MedlineGoogle Scholar6. PORTLOCKROSENBERGGLATSTEINKAPLAN CSEH: Treatment of advanced non-Hodgkin's lymphomas with favorable histologies: preliminary results of a prospective trial. Blood 47:747-756, 1976 CrossrefMedlineGoogle Scholar7. REIMERHOOVERFRAUMENIYOUNG RRJR: Acute leukemia after alkylating-agent therapy of ovarian cancer. N Engl J Med 297:177-181, 1977 CrossrefMedlineGoogle Scholar8. COLEMANWILLIAMSFLINTGLATSTEINROSENBERGKAPLAN CCAESH: Hematologic neoplasia in patients treated for Hodgkin's disease. N Engl J Med 297:1249-1252, 1977 CrossrefMedlineGoogle Scholar9. O'DONNELLBRERETONGRECOGRALNICKGALLAGHERPENGJOHNSON JHFHRJR: Acute myelocytic leukemia (AML) and acute myeloproliferative syndrome (AMPS) after therapeutic irradiation for non-Hodgkin's lymphoma (abstract). Proc Am Assoc Cancer Res 19:60, 1978 Google Scholar10. JONESHUBBARDOSBORNEMERRILLGARVINYOUNGDEVITA RSCJJRV: Histologic conversions in non-Hodgkin's lymphoma: evolution of nodular lymphomas to diffuse lymphomas (abstract). Clin Res 26:437A, 1978 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Clinical Pharmacology Branch Division of Cancer Treatment National Cancer Institute Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe non‐Hodgkin's lymphomasThe Role of Radiation Therapy in Malignant Lymphomas, Including Hodgkin’s DiseaseTHE TREATMENT OF MYCOSIS FUNGOIDES WITH PUVA 1 January 1979Volume 90, Issue 1Page: 115-117KeywordsLymphoma ePublished: 1 December 2008 Issue Published: 1 January 1979 PDF downloadLoading ...