tbuckley/cabot-search huggingface dataset:
Trimeton, a New Antihistaminic Drug
Authors: Irving W. Schiller, Francis C. Lowell
Journal: New England Journal of Medicine (1949)

THOUGH the evidence is still very indirect that histamine is responsible for the allergic reaction,1 , 2 the effectiveness of the antihistaminic drugs in the symptomatic control of hay fever, urticaria and certain cases of perennial allergic rhinitis is well recognized. On the other hand, the value of these drugs in bronchial asthma, allergic dermatoses and drug allergy is questionable. The reason for lack of benefit in these conditions is not clear. The experience with pyribenzamine ointment in the treatment of skin conditions suggests that higher concentrations at the involved site are an important factor. Furthermore, in studies in this laboratory, it . . .
THE NERVOUS PHENOMENA ASSOCIATED WITH MOVABLE KIDNEY.
Authors: WHARTON SINKLER
Journal: JAMA (1904)

It is only within a comparatively recent period that the attention of the profession has been directed to the frequent occurrence of movable or floating kidney, and it is within a still more recent time that the importance of the symptoms arising from this condition has been appreciated. The frequency of movable kidney is a point on which there has been wide diversity of opinion. All authorities agree that movable kidney is much more common in women than in men, and it is also agreed that it most frequently occurs between the ages of 25 and 40 years, and is rarely found in girls before puberty. It is also most common in women who have been pregnant. Some writers state that this condition of the kidneys is found in 25 per cent. of women who are examined for pelvic, dyspeptic or other troubles, while others regard the condition as comparatively
NCI and CCSG Examine Role of Electromagnetic Fields In Childhood Leukemia
Authors: M. E. Newman
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article NCI and CCSG Examine Role of Electromagnetic Fields In Childhood Leukemia Get access Michael E. Newman Michael E. Newman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 3, 7 February 1990, Pages 175–176, https://doi.org/10.1093/jnci/82.3.175 Published: 07 February 1990
Points: Services for people with head injury
Authors: M. J Rose, R L. Wood
Journal: BMJ (1985)

relatively little time available to talk to their inpatients because they are responsible for patients in several hospitals and are also concerned in work in the community, which may be particularly time consuming.Psychiatric firms usually have one junior trainee per site (or part ofone), and there are no housemen, so on call duties are shared by SHOs/registrars, whose posts usually coalesce to form training programmes involving enough firms and units to allow varied experience in a rotating scheme.Cuts in the numbers of junior psychiatric training posts are being proposed in many places and in some cases are draconian.If these numbers are reduced in this way without either a significant increase in consultant numbers or a commensurate increase in non-trainee junior posts then the standard of service may decline unacceptably in many places.Some regions err in supposing that manpower needs and use in psychiatry are essentially the same as in medical and surgical specialties.
Recurrent Cerebrovascular Events Associated with Patent Foramen Ovale, Atrial Septal Aneurysm, or Both
Authors: Jean-Louis Mas, Caroline Arquizan, Catherine Lamy, Mathieu Zuber, Laure Cabanes, Geneviève Derumeaux, Joël Coste
Journal: New England Journal of Medicine (2001)

Patent foramen ovale and atrial septal aneurysm have been identified as potential risk factors for stroke, but information about their effect on the risk of recurrent stroke is limited. We studied the risks of recurrent cerebrovascular events associated with these cardiac abnormalities.A total of 581 patients (age, 18 to 55 years) who had had an ischemic stroke of unknown origin within the preceding three months were consecutively enrolled at 30 neurology departments. All patients received aspirin (300 mg per day) for secondary prevention.After four years, the risk of recurrent stroke was 2.3 percent (95 percent confidence interval, 0.3 to 4.3 percent) among the patients with patent foramen ovale alone, 15.2 percent (95 percent confidence interval, 1.8 to 28.6 percent) among the patients with both patent foramen ovale and atrial septal aneurysm, and 4.2 percent (95 percent confidence interval, 1.8 to 6.6 percent) among the patients with neither of these cardiac abnormalities. There were no recurrences among the patients with an atrial septal aneurysm alone. The presence of both cardiac abnormalities was a significant predictor of an increased risk of recurrent stroke (hazard ratio for the comparison with the absence of these abnormalities, 4.17; 95 percent confidence interval, 1.47 to 11.84), whereas isolated patent foramen ovale, whether small or large, was not.Patients with both patent foramen ovale and atrial septal aneurysm who have had a stroke constitute a subgroup at substantial risk for recurrent stroke, and preventive strategies other than aspirin should be considered.
Abnormalities of cardiac autonomic function and 11C-hydroxyephedrine PET coincide in heart failure
Authors: Liisa-Maria Voipio-Pulkki, Risto Vesalainen, Mikko Pietilä, Tuomas Jartti, Heikki Ukkonen, Mike Teräs, Kjell Någren, Pertti Lehikoinen, Juhani Knuuti, Kari Tahvanainen
Journal: Journal of the American College of Cardiology (1996)
Sex Differences in Blood-Oxygenation-Level-Dependent Functional MRI With Primary Visual Stimulation
Authors: Jonathan M. Levin, Marjorie H. Ross, Jack H. Mendelson, Nancy K. Mello, Bruce M. Cohen, Perry F. Renshaw
Journal: American Journal of Psychiatry (1998)

OBJECTIVE: The authors evaluated the effect of sex on data derived from activation studies using blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (MRI). METHOD: Gradient echo-echo planar imaging was used to measure BOLD signal response in the primary visual cortex in response to binocular photic stimulation in 16 healthy, young subjects (eight women and eight men). RESULTS: BOLD signal response was 38% lower in women than in men, and much of the difference was lateralized to the right hemisphere. CONCLUSIONS: Lower BOLD signal response in women may reflect a sex difference in the brain's response to a primary visual stimulation or in the physiology underlying BOLD functional MRI signal changes.
OLDER IS WISER: LOW-DENSITY LIPOPROTEIN CHOLESTEROL GOAL ATTAINMENT IN A MULTINATIONAL SURVEY OF DYSLIPIDEMIC PATIENTS: A LIPID TREATMENT ASSESSMENT PROJECT (L-TAP) 2 SUBSTUDY
Authors: Raul D. Santos, David D. Waters, Jean Ferrieres, J-Wouter Jukema, Cheng-Wen Chiang, Michael Messig, Lisa Tarasenko
Journal: Journal of the American College of Cardiology (2010)
The CAVENDISH LECTURE on SOME PHASES of INFLAMMATION of the APPENDIX: Delivered before the West London Medico-Chirurgical Society on June 20th, 1902
Authors: F. Treves
Journal: BMJ (1902)

MR. PRESIDENT AND GENTLEMEN,-Among those circum- stances which are remarkable in the history of medicine in the closing years of the nineteenth century, few are more curious than the almost abrupt appearance of the disease now known as appendicitis.Less than twenty years ago this malady was practically unrecognized, it found no accepted place in the systematic manuals of medicine, and its very name had not been called into being.The title " appendicitis " was proposed by Fitz' in a com- munication published in i886, and although the term is uncouth and lacking in preciseness, it at once found a place in the clumsy nomenclature of medicine.In spite of many protests from the academically minded, the word has passed into general use, and has received, moreover, the liberal patronage of the lay public.There is a bold aggressive
Clinical Trial of Methyprylone, a Piperidine Hypnotic
Authors: J. S. Stewart
Journal: BMJ (1956)

Few of those who have spent their illnesses in more secluded places realize how much noise there can be in a hospital ward at night.The usual practice in the ear, nose, and throat department of this hospital is therefore to offer adult patients a hypnotic such as amylobarbi- tone sodium or butobarbitone.Methyprylone (" noludar," 2,4-dioxo-3,3-diethyl-5- methyl-piperidine) has been found to be a safe and effective sedative-hypnotic in doses of 200-400 mg., with a fairly prompt onset, short duration of action, and no side-effects (Cass et al., 1955).It is well tolerated by older patients in whom barbiturates are apt to produce confusion and sometimes delirium (Schmitt, 1955).This has been confirmed by Kemper (1955) in elderly psychiatric patients.Brandlman et al. (1955), using methyprylone in doses of 2S0 mg., reported occasional drowsiness, dizziness, and headache. Present InvestigationThe object of the trial was to compare the hypnotic effects of amylobarbitone sodium, butobarbitone, methy- prylone, and a control tablet in patients admitted to the ear, nose, and throat wards.The results were assessed objec-
Treatment of Bleeding Esophageal Varices
Authors: Robert Edmunds
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The criteria for determining that the two groups were comparable were stated in our original paper (<i>Ann Surg</i><b>154:</b>41, 1961), reference 6 in ourJournalcommunication. The only reason that the medical group was not treated surgically was that the patient or his doctor did not agree to surgery.
Redefinition of the human mast cell transcriptome by deep-CAGE sequencing
Authors: Efthymios Motakis, Sven Guhl, Yuri Ishizu, Masayoshi Itoh, Hideya Kawaji, Michiel de Hoon, Timo Lassmann, Piero Carninci, Yoshihide Hayashizaki, Torsten Zuberbier, Alistair R. R. Forrest, Magda Babina
Journal: Blood (2014)
Dendritic cell–mediated activation-induced cytidine deaminase (AID)–dependent induction of genomic instability in human myeloma
Authors: Srinivas Koduru, Ellice Wong, Till Strowig, Ranjini Sundaram, Lin Zhang, Matthew P. Strout, Richard A. Flavell, David G. Schatz, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Journal: Blood (2012)
Nitrous Oxide Analgesia-Reply
Authors: Martin T. Fosburg
Journal: JAMA (1984)

<h3>In Reply.—</h3> This letter raises several points that deserve further elaboration. There is no doubt that patients who have undergone treatment for cancer have a variety of complex medical problems, including myocardial dysfunction. In our opinion, once it has been established that a patient in severe pain is near death, treatment of pain becomes the overriding issue despite any concurrent medical problems. The approach to pain control will vary depending on circumstances, and it is clear that any intervention, including epidural analgesia or anesthesia as well as nitrous oxide, will have potential complications. We have proposed that nitrous oxide analgesia is one way of treating intractable pain that deserves consideration. In our experience, cardiovascular side effects were not obvious and patients' moods and level of consciousness improved rather than diminished. Since our end point is patient comfort rather than physiological stability, we believe that repeated assessment of vital signs is
A practice audit of oral contraceptive users.
Authors: W Reith
Journal: BMJ (1983)

The level of care provided to oral contraceptive (OC) users in a general practice in Aberdeen Scotland was evaluated.  The records of the 262 current OC acceptors were audited for 1) record of menstrual history 2) blood pressure measurement before starting contraceptive use 3) blood pressure measurement at 1st follow-up visit 4) weight 5) urine analysis 6) pelvic examination and cervical smear and 7) rubella titer.  Patients were divided into 2 groups.  Group 1 (178 women) included those who had been taking OCs for more than 1 year and Group 2 (84 women) consisted of those who had been using the pill for less than 1 year.  Women in both groups were similar in terms of marital status nulliparity and type of preparation prescribed (combined or progesterone only pill).  However 30% of the women in Group 1 compared with 50% of those in Group 2 had been prescribed OCs after pregnancy.  Moreover higher percentages of women in Group 2 had measurements recorded for the variables under study.  These differences were significant in the cases of measurements of pretreatment blood pressure (60.1% in Group 1 vs. 77.3% in Group 2) weight (54.5% vs. 80.9%) urine analysis (44.9% vs. 66.7%) and rubella titer (37.1% vs. 59.5%).  This improvement in the more recently treated group may reflect the increase in number of women who are attending for postnatal examination.  This examination has been scheduled to coincide with the 6-week pediatric screening visit and attendance has reached 100%.  As a result of this study the practice plans to institute the following standards of care:  1) record blood pressure at initial consultation and at each subsequent visit before prescribing oral contraception 2) record weight at initial consultation 3) advise on rubella screening at the initial or 1st review consultation and 4) advise on cervical cytology examination and vaginal examination in the 1st year of contraceptive use.  This study will be repeated in 2 years.
Moral competence is cognitive but (perhaps) nonmodular
Authors: Susan Dwyer
Journal: Behavioral and Brain Sciences (1996)

Abstract Barresi &amp; Moore's account has at least two implications for moral psychology. First, it appears to provide support for cognitive theories of moral competence. Second, their claim that the development of social understanding depends upon domain-general changes in cognitive ability appears to oppose the idea that moral competence is under-pinned by a moral module.
Human autoantibodies against desmoplakins in paraneoplastic pemphigus.
Authors: J R Oursler, R S Labib, L Ariss-Abdo, T Burke, E J O'Keefe, G J Anhalt
Journal: Journal of Clinical Investigation (1992)

Recently, a previously unrecognized autoantibody mediated blistering disease, paraneoplastic pemphigus has been described. Paraneoplastic pemphigus is associated with lymphoid malignancies, thymomas, and poorly differentiated sarcomas. Serum of affected patients contain pathogenic autoantibodies that immunoprecipitate from normal keratinocytes a characteristic complex of four polypeptides with M(r) of 250, 230, 210, and 190 kD. As our preliminary studies indicated that the 250-kD and the 210-kD antigens comigrated with desmoplakins I and II, we investigated the possibility that autoantibodies against the desmoplakins were a component of this autoimmune syndrome. 11 sera from affected patients were tested by indirect immunofluorescence against desmosome containing tissues, immunoprecipitation of metabolically labeled keratinocytes, and Western immunoblotting of desmoplakins I and II that had been purified to homogeneity from pig tongue epithelium. By indirect immunofluorescence, 9 of 11 sera showed strong binding to epithelial and nonepithelial desmosomes, and 2 were weakly reactive. All 11 immunoprecipitated 250- and 210-kD bands of variable intensity that comigrated with bands identified by a murine monoclonal antidesmoplakin antibody, and immunoblotting confirmed binding of the serum autoantibodies to purified desmoplakins. This demonstrates that paraneoplastic pemphigus is the first human autoimmune syndrome in which autoantibodies against the desmoplakins are a prominent component of the humoral autoimmune response.
Abstract P6-07-42: Patients with Nipple-areola Paget's Disease and Underlying Invasive Breast Carcinoma had a Very Poor Survival: a Matched Cohort Study
Authors: H Ling, X-L Xu, Z-B Liu, Z-M Shao
Journal: Cancer Research (2012)

Abstract Purpose: Nipple-areola Paget's disease together with invasive breast cancer is a rare kind of disease. This study is to investigate the characteristic and survival of it. Patients: From 2001 to 2005, all patients diagnosed as nipple-areola Paget's disease with underlying invasive breast carcinoma in Fudan University Shanghai Cancer Center (FUSCC) were recruited in this study (PD group). Patients diagnosed as invasive breast cancer without Paget's disease were recruited in control group for clinical and pathologic features comparison. Since tumors in PD group expressed more high risk factors (see results), a matched study was done to investigate whether the poor survival of PD group was by nature or due to the overexpression of high risk factors. The matched group was derived from all the patients who received mastectomy for invasive breast cancer (with no Paget's disease) during 2001 to 2005 in FUSCC. The match was conducted according to four variables: dimension of tumor, lymph node status, hormone receptor status and Her2 status. After matching, patients were randomly selected in a 3:1 ratio to patients in PD group. Results: 52 patients were recruited in PD group. 22 (42.3%) patients' primary symptom were nipple change, 25 (48.1%) patients' primary symptom were mass in breast. Physical examination found no nipple-areola change in 24 patients at diagnosis, their Paget's disease were found unexpectedly by routine nipple-areola section examination after mastectomy. More than 8000 invasive breast cancers were diagnosed during 2001 to 2005. 700 patients (140 consecutive patients per year, average monthly patient amount) were recruited in control group. Compared with control group, tumors in PD group had larger size, more axillary lymph node involvement, lower hormone receptor expression, higher HER2 expression and worse survival. 156 patients were recruited in the matched group. The 5-year relapse-free survival and overall survival were both lower for patients in PD group than those in the matched group (table1). Conclusions: Patients with invasive breast cancer and Paget's disease tended to have larger size, more lymph nodes involvement, lower hormone receptor expression, higher HER2 expression and worse survival than those without PD. The matched study confirmed the survival disadvantage of patients with Paget's disease and underlying invasive breast cancer. Thus, oncologists should regard such patients as having high risk for relapse. Pathologists should exam the nipple-areola section carefully after mastectomy although the patient has no macroscopic nipple-areola change. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P6-07-42.
Work of a rehabilitation medicine service.
Authors: C. W. Roy, Y. Arthurs, J. Hunter, S. Parker, A. McLaren
Journal: BMJ (1988)

The results of the work of the Edinburgh Rehabilitation Medicine Service in one year were evaluated. Over 1400 new patients were seen, of whom 525 were in hospital at the time. Patients most often referred were those who had had cardiovascular accidents, back pain, lower limb amputations, and head injuries and those convalescing after heart surgery. Most patients had several problems. Many were referred so that they could obtain wheelchairs or other appliances, or for assessment of their ability to drive. Only 3% of the referrals were considered inappropriate. Of the inpatients, 455 (87%) returned home after treatment, but 13 (2%) did not respond satisfactorily to rehabilitation. Twelve per cent (18% of the inpatients) were referred from other health boards, suggesting a need for similar facilities elsewhere.
Inherited C2 Deficiency and Systemic Lupus Erythematosus: Studies on a Family
Authors: C. K. OSTERLAND
Journal: Annals of Internal Medicine (1975)

A patient is described in which an inherited defect in the synthesis of C2 complement component coexisted with the disease systemic lupus erythematosus. The family studies show evidence of the autosomal recessive nature of the inheritance of the C2 synthesis defect. Of particular interest was the finding of a great-aunt who also had homozygous C2 deficiency. This great-aunt suffered from discoid lupus erythematosus as well. The occurrence of various autoantibodies in the serum from the family members, the typing for blood groups, HL-A antigens, and some serum protein markers are reported and discussed. The C2 deficiency may be a critical defect in the host defenses to infection that predisposed to the development of autoimmune disease.
NOTES OF A CASE OF ACUTE SUPPURATIVE PANCREATITIS WITH REPORT OF NECROPSY.
Authors: I. E. ATKINSON
Journal: JAMA (1895)

Acute suppurative inflammation of the pancreas is so rarely recognized during the lifetime of the paient, that I have thought that the details of the following case, in which it was possible to make a correct diagnosis while the patient was yet alive, would prove sufficiently interesting to engage your attention for a few moments. I was called to see, on Dec. 2, 1894, Mrs. S., the mother of two children, one 12 years, the other six months old. She was 35 years of age, with dark hair and eyes, tall and unusually stout, though it was thought she had lost nearly forty pounds during her illness. She had enjoyed excellent health until fifteen months previously when she was seized with a severe attack of what her physician told her was hepatic colic, and which was followed by intense jaundice within two days. The attack lasted three weeks, with the
THE EFFECTS OF LOSS OF GASTRIC AND PANCREATIC SECRETIONS AND THE METHODS FOR RESTORATION OF NORMAL CONDITIONS IN THE BODY
Authors: Alexis F. Hartmann, Robert Elman
Journal: The Journal of Experimental Medicine (1929)

The composition of gastric and pancreatic juices and the effects of their loss on the composition of the body fluids were studied. Loss of gastric juice by removing water and chloride ions only partly neutralized by fixed base results in dehydration and alkalosis. Loss of pancreatic juice by removing water and a relative excess of fixed base results in dehydration and acidosis. Normal conditions in the body may be restored after the loss of either gastric or pancreatic juice by the administration of a combined solution, which provides (1) water in abundance because of its hypotonicity (2) an adequate source of the fixed anion Cl' and of the cations Na+, K+, and Ca++ in proper physiological ratio and (3) an excess of fixed base over fixed acid in the form of B-lactate.