The Proper Use of Newer Diuretics
Authors: JOHN H. LARAGH
Journal: Annals of Internal Medicine (1967)

Diagnosis and Treatment1 September 1967The Proper Use of Newer DiureticsJOHN H. LARAGH, M.D., F.A.C.P.JOHN H. LARAGH, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-606 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction of chlorothiazide (1) as the first really effective oral diuretic has marked the beginning of a new era in the treatment of edematous and hypertensive disorders. The development of this compound (2) thus stands as one of the most significant advances in clinical medicine of the past decade. The use of chlorothiazide and of the many similar compounds subsequently derived from it has undoubtedly resulted in significant to striking symptomatic relief and the prolongation of life of countless numbers of patients suffering from the common medical disorders so often accompanied by fluid accumulation.In the past 10 years...References1. LARAGHHEINEMANNDEMARTINI JHHOFE: Effect of chlorothiazide on electrolyte transport in man. Its use in the treatment of edema of congestive heart failure, nephrosis and cirrhosis. JAMA 166: 145, 1958. CrossrefMedlineGoogle Scholar2. BEYERBAERRUSSOHAIMBACH KHJEHFAS: Chlorothiazide (6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide): enhancement of sodium chloride excretion. Fed. Proc. 16: 282, 1957. Google Scholar3. LARAGH JH: Hormones and the pathogenesis of congestive heart failure: vasopressin, aldosterone, and angiotensin II. Further evidence for renal-adrenal interaction from studies in hypertension and in cirrhosis. Circulation 25: 1015, 1962. CrossrefMedlineGoogle Scholar4. AMESBORKOWSKISICINSKILARAGH RPAJAMJH: Prolonged infusions of angiotensin II and norepinephrine and blood pressure, electrolyte balance, and aldosterone and cortisol secretion in normal man and in cirrhosis with ascites. J. Clin. Invest. 44: 1171, 1965. CrossrefMedlineGoogle Scholar5. DEWARDENERMILLSCLAPHAMHAYTER HEIHWFCJ: Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin. Sci. 21: 249, 1961. MedlineGoogle Scholar6. JOHNSTONDAVIS CIJO: Evidence from cross circulation studies for a humoral mechanism in the natriuresis of saline loading. Proc. Soc. Exp. Biol. Med. 121: 1058, 1966. CrossrefMedlineGoogle Scholar7. DIRKSCIRKSENABERLINER JHWJRW: The effect of saline infusion on sodium reabsorption by the proximal tubule of the dog. J. Clin. Invest. 44: 1160, 1965. CrossrefMedlineGoogle Scholar8. CIRKSENADIRKSBERLINER WJJHRW: Effect of thoracic cava obstruction on response of proximal tubule sodium reabsorption to saline infusion. J. Clin. Invest. 45: 179, 1966. CrossrefMedlineGoogle Scholar9. LARAGH JH: The mode of action and use of chlorothiazide and related compounds. Circulation 26: 121, 1962. CrossrefMedlineGoogle Scholar10. HEINEMANNDEMARTINILARAGH HOFEJH: The effect of chlorothiazide on renal excretion of electrolytes and free water. Amer. J. Med. 26: 853, 1959. CrossrefMedlineGoogle Scholar11. CANNONHEINEMANNSTASONLARAGH PJHOWBJH: Ethacrynic acid. Effectiveness and mode of diuretic action in man. Circulation 31: 5, 1965. CrossrefMedlineGoogle Scholar12. STASONCANNONHEINEMANNLARAGH WBPJHOJH: Furosemide, a clinical evaluation of its diuretic action. Circulation 34: 910, 1966. CrossrefMedlineGoogle Scholar13. DEMARTINIWHEATONHEALEYLARAGH FEEALAJH: Effect of chlorothiazide on the renal excretion of uric acid. Amer. J. Med. 32: 572, 1962. CrossrefGoogle Scholar14. CANNONSTASONDEMARTINISOMMERSLARAGH PJWBFESCJH: Hyperuricemia in primary and renal hypertension. New Eng. J. Med. 275: 457, 1966. CrossrefMedlineGoogle Scholar15. LAWRASONALPERTMOHRMCMAHON FDEFLFG: Ulcerative-obstructive lesions of the small intestine. JAMA 191: 641, 1965. CrossrefMedlineGoogle Scholar16. KASSIRERSCHWARTZ JPWB: The response of normal man to selective depletion of hydrochloric acid. Factors in the genesis of persistent gastric alkalosis. Amer. J. Med. 40: 10, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, N. Y.This paper was presented in part at the Third International Congress of Nephrology, September 28, 1966, Washington, D. C.Requests for reprints should be addressed to John H. Laragh, M.D., 180 Fort Washington Ave., New York, N. Y. 10032. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEpithelial Sodium Channel Inhibition by Amiloride on Blood Pressure and Cardiovascular Disease Risk in Young PrehypertensivesMANAGEMENT OF ASCITESASCITESRenin–Angiotensin–Aldosterone System and the Renal Regulation of Sodium, Potassium, and Blood Pressure HomeostasisThe Convergent Synthesis of [1, 3]-Thiazino[2, 3-f]-Theophylline and [1, 3]-Thiazino[3, 2-e] Theophxlline Ring SystemsAn Update of Congestive Heart Failure in InfantsReduction of the Endocochlear Potential by the New "Loop" Diuretic, BumetanideReduction of the Endocochlear Potential by the New "Loop" Diuretic, BumetanideModern system for treating high blood pressure based on renin profiling and vasoconstriction-volume analysis: A primary role for beta blocking drugs such as propranololINCREASE IN SERUM-LIPIDS DURING TREATMENT OF HYPERTENSION WITH CHLORTHALIDONECyanotic congenital heart diseaseComparison of the cochlear toxicity of sodium ethacrynate, furosemide, and the cysteine adduct of sodium ethacrynate in catsVolume-dependent essential and steroid hypertensionHerz und Grosse GefässeRecognition and management of cardiologic problems in the newborn infantTherapy of Complicated Arterial HypertensionHerz und Grosse GefässeCongestive Heart Failure in the InfantManagement of Cardiac Problems in the Intensive Care UnitEthacrynic acid and furosemideREFERENCESDiuretics in the Management of Congestive Heart FailureComplications of diuretic therapy: Severe alkalosis and syndrome resembling inappropriate secretion of antidiuretic hormoneEthacrynic acid: Its usefulness and untoward effectsEthacrynic acid and furosemideAmiloride利尿薬の臨床薬理 1 September 1967Volume 67, Issue 3_Part_1Page: 606-613KeywordsDiureticsNephrologyOral medicineSurgeons Issue Published: 1 September 1967 PDF DownloadLoading ...