tbuckley/cabot-search huggingface dataset:
Bridging of Benign Choledochal Stenoses by Endoscopic Retrograde Implantation of Mesh Stents
Authors: E. C. Foerster, N. Hoepffner, W. Domschke
Journal: Endoscopy (1991)

A prospective study of a new stent for bridging choledochal stenoses was performed in seven patients (5 females, 2 males, age range 49-80 years) with benign bile duct stenosis or bilioduodenal fistula in whom conventional bougienage (3 patients) and/or month-long implantation of plastic prostheses (7 patients) failed because of reocclusion. The self-expanding mesh stents (Wallstent) were implanted by duodenoscopy in six patients. In one patient with a B-II stomach, the stent could only be inserted by the percutaneous transhepatic route. All prostheses were inserted endoscopically without complications. At follow-up after an average of eight months prosthesis-related complications were found in only one patient; there was no case of prosthesis occlusion. One patient with a bilioduodenal fistula of unknown origin developed fever and sepsis three days after implantation and subsequently a liver abscess which resolved on repeated drainage and antibiotic therapy. Although definitive interpretation of the results requires a longer follow-up period, on the basis of the present data endoscopic reconstructive splinting of benign choledochal stenosis would appear to be a promising technique.
Impact of Diet Modification on Food Product Development
Authors: Robert G. Bursey
Journal: Annals of Internal Medicine (1983)

Dialogue Summaries1 May 1983Impact of Diet Modification on Food Product DevelopmentRobert G. Bursey, Ph.D.Robert G. Bursey, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-883_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe diet of the American public is in a constant state of flux. Dietary alterations are based on the everchanging needs and perceptions of the consumer. Concern about the relation of diet to health is only one element of perceived needs. The needs of the consumer influence the process of food product development. Evidence of that impact is apparent in the large number of new food products designed to meet special dietary needs avilable in the market place.Interpreting the perceived needs of the consumer is often difficult. For most consumers, quality and safety are the most important concerns. The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert G. Bursey, Ph.D.Affiliations: Kraft, Inc. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1983Volume 98, Issue 5_Part_2Page: 833-833KeywordsDietFoodPerceptionSafety ePublished: 1 December 2008 Issue Published: 1 May 1983 PDF downloadLoading ...
Assessment of liver fibrosis using transient elastography in patients with alcoholic liver disease
Authors: Pierre Nahon, Adrien Kettaneh, Iulia Tengher-Barna, Marianne Ziol, Victor de Lédinghen, Catherine Douvin, Patrick Marcellin, Nathalie Ganne-Carrié, Jean-Claude Trinchet, Michel Beaugrand
Journal: Journal of Hepatology (2008)
Arterial Embolism to the Legs Late Embolectomy
Authors: George E. Reed
Journal: JAMA (1963)

SUCCESSFUL RESTORATION of circulation in embolic occlusions of 24 to 96 hours' duration of arteries of the lower extremities is reported. Factors affecting results in these patients operated on showed that extended time of occlusion is not a deterrent to salvage of limb and function. <h3>Diagnosis</h3> Differentiation between embolic and thrombotic occlusion is essential. Embolectomy is recommended except when another disease is life-threatening, whereas operation for acute thrombotic occlusion is to be avoided except under specific conditions. Arteriography is the most specific diagnostic procedure and can be done with little loss of time or additional hazard. Emboli lodge where vessels narrow, usually at major bifurcations. A concavity in the distal end of the radiopaque dye column, "the inverted meniscus sign," is pathognomonic of embolic occlusion (Fig 1). An exception occurs in the distal superficial femoral artery where emboli may seat at the adductor magnus hiatus, some distance from a proximal
Public Policy and Risk of a Haircut
Authors: Khalid L. Rehman
Journal: Annals of Internal Medicine (1997)

Letters15 September 1997Public Policy and Risk of a HaircutKhalid L. Rehman, MDKhalid L. Rehman, MDSt. Vincent's Medical Center; Staten Island, NY 10310Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-6-199709150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The brief study of the potential risks of a haircut reported by Gitlin and colleagues [1] has led to an amendment to the public health codes in New York State. This report had shown that hepatitis C virus RNA was not destroyed by the antiseptic solutions used in barber shops. The study highlighted the risks of the nondisposable razors often used for shaves and trimming of the sideburns and the back of neck. After reading this letter, I visited my local barber shop and discovered that some barbers were still using old-fashioned straight razors. I brought this ...References1. Gitlin N, Nolte FS, Weiss M. Hepatitis C: risk of a haircut [Letter]. Ann Intern Med. 1997; 126:410-1. Google Scholar2. Eisner R. Say so long to the old fashioned shaves. The Staten Island Advance. 12 May 1997:1. Google Scholar Author, Article, and Disclosure InformationAuthors: Khalid L. Rehman, MDAffiliations: St. Vincent's Medical Center; Staten Island, NY 10310 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1997Volume 127, Issue 6 Page: 494 Keywords Health care policy reports Hepatitis C virus Prevention, policy, and public health Public policy Risk management RNA ePublished: 15 August 2000 Issue Published: 15 September 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
So how <i>do </i>they do it?
Authors: R. I. M. Dunbar
Journal: Behavioral and Brain Sciences (2001)

While the evidence that cetaceans exhibit behaviours that are every bit as cultural as those recognised in chimpanzees is unequivocal, I argue that it is unlikely that either taxon has the social cognitive mechanisms required to underpin the more advanced forms of culture characteristic of humans (namely those that depend on shared meaning).
von Willebrand disease associated with familial thrombocytopenia and increased ristocetin‐induced platelet aggregation
Authors: Hoyu Takahashi, Reizo Nagayama, Akira Hattori, Toshio Ihzumi, Tsuneyasu Tsukada, Akira Shibata
Journal: American Journal of Hematology (1981)

Abstract Two cases of von Willebrand disease (vWD) associated with familial thrombocytopenia were reported. The proband (daughter) and her father showed thrombocytopenia with large platelets and decreased von Willebrand factor activity (VIIIR:WF). Factor VIII procoagulant activity (VIII:C) and factor VIII‐related antigen (VIIIR:AG) were normal, but both patients revealed an increased ristocetin‐induced platelet aggregation and a qualitative abnormality of the factor VIII protein, which was characterized by fast electrophoretic mobility of VIIIR:AG and an abnormal elution of factor VIII‐related activities on Sepharose 2B. DDAVP was hemostatically effective even in this thrombocytopenic patient undergoing a dental extraction.
A task-oriented taxonomy of visual completion
Authors: Carol Yin
Journal: Behavioral and Brain Sciences (1998)

Differences and similarities between modal and amodal completions can only be understood by considering the goals of visual completion: unity, shape, and perceptual quality. Pessoa et al. cannot reject representational accounts of vision because of flaws with isomorphic representations of perceptual quality: representations and processes for perceptual quality (modal completion) and most likely dissociable from those for unity and shape (nonmodal completions).
Platypnea after Pneumonectomy
Authors: Raymond Begin
Journal: New England Journal of Medicine (1975)

PLATYPNEA (dyspnea produced by assumption of an erect position and relieved by a recumbent one1) as a post-pneumonectomy complication has rarely been observed in the past.2 In the patient described below, severe platypnea and orthostatic cyanosis developed after pneumonectomy and were cured by operation.Case ReportA 47-year-old man, two months after resection of the right lung because of lung cancer, was readmitted to the hospital complaining of severe respiratory distress and cyanosis beginning in the sitting posture and exaggerated in the standing position. Supine posture relieved these symptoms. Physical examination confirmed the history. The left lung was clear. . . .
Improving Medication Adherence and Helping Patients Make Lifestyle Changes
Authors: Daniel D. L. Bernal, Luke R. E. Bereznicki, Gregory M. Peterson
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses
Authors: Harumichi Ishigame, Shigeru Kakuta, Takeshi Nagai, Motohiko Kadoki, Aya Nambu, Yutaka Komiyama, Noriyuki Fujikado, Yuko Tanahashi, Aoi Akitsu, Hayato Kotaki, Katsuko Sudo, Susumu Nakae, Chihiro Sasakawa, Yoichiro Iwakura
Journal: Immunity (2009)
Bile acid-independent bile flow is differently regulated by glucagon and secretin in humans after orthotopic liver transplantation
Authors: R Lenzen, J Elster, C Behrend, K Hampel, W Bechstein, P Neuhaus
Journal: Hepatology (1997)

The present study characterizes recovery of bile secretion after orthotopic liver transplantation (OLT) in humans with special regard to hormonal regulation of bile acid-independent bile flow by glucagon and secretin. Sixty-seven patients with an uncomplicated postoperative course were studied during the first 3 weeks after OLT to determine normalization of bile flow. A group of 7 and 10 patients, respectively, underwent a biliary stimulation test by either glucagon at days 7, 14, and 21 after OLT or by secretin at days 2, 10, and 21 after OLT. Secretin tests were similarly performed in patients with acute severe rejection during the first 10 days after OLT, while glucagon tests were performed in patients with acute allograft rejection occurring 2 weeks after OLT. Furthermore, hormone effects were studied in nontransplanted patients after cholecystectomy with indwelling biliary T tube. After OLT, bile secretory function recovered and stabilized within 14 days after surgery by reconstitution of both bile acid-dependent and -independent bile flow. Two weeks after OLT, bile secretion was comparable with nontransplanted patients after cholecystectomy. Glucagon and secretin stimulated bile acid-independent bile flow in transplanted and nontransplanted patients significantly, yet secretin choleresis, unlike glucagon choleresis, had already occurred during the first days after OLT and was unaffected by acute allograft rejection. These results allow the speculation that, in humans, glucagon and secretin exert their choleretic activity by different mechanisms and/or at different anatomical sites in the liver. Assuming that secretin acts at the bile duct cells, its secretory capacity was not altered by the transplantation procedure and during moderate or severe rejection episodes, as opposed to glucagon choleresis, which most likely originates in the hepatocytes and requires an entirely reconstituted canalicular transport system after OLT.
Skunk poses higher risk of psychosis than traditional hash
Authors: J. Wise
Journal: BMJ (2009)

The risk of psychosis is much greater with the more potent skunk form of cannabis than with traditional hash, researchers from the Institute of Psychiatry in London have concluded.

Their case-controlled study found that people who smoke skunk or sinsemilla are almost seven times as likely to have psychotic illnesses such as schizophrenia than people who use ordinary cannabis ( British Journal of Psychiatry 2009;195:488-91, doi:10.1192/bjp.bp.109.064220).

Information on cannabis use was collected from 280 cases of patients presenting with a first episode of psychosis to the South London and Maudsley NHS Foundation Trust and from 174 healthy controls recruited from the local population. The mean age of the patients was …
Defective Awakening Response to Nocturnal Hypoglycemia in Patients with Type 1 Diabetes Mellitus
Authors: Bernd Schultes, Kamila Jauch-Chara, Steffen Gais, Manfred Hallschmid, Eva Reiprich, Werner Kern, Kerstin M Oltmanns, Achim Peters, Horst L Fehm, Jan Born
Journal: PLoS Medicine (2007)

Nocturnal hypoglycemia frequently occurs in patients with type 1 diabetes mellitus (T1DM). It can be fatal and is believed to promote the development of the hypoglycemia-unawareness syndrome. Whether hypoglycemia normally provokes awakening from sleep in individuals who do not have diabetes, and whether this awakening response is impaired in T1DM patients, is unknown.
Breast surgeons are referred to GMC for refusing to take part in a review of their unit
Authors: Clare Dyer
Journal: BMJ (2012)

<h3>Objective</h3> To evaluate the efficacy, safety, pharmacokinetics, and immunogenicity of CNTO6785, a fully human monoclonal antibody that binds to human interleukin 17A, in patients with active rheumatoid arthritis (RA) with inadequate response to methotrexate (MTX) therapy. <h3>Methods</h3> This randomized, double-blind, placebo-controlled, dose-ranging study enrolled patients aged 18 to 80 years (inclusive) with active RA (≥ 6/66 swollen and ≥ 6/68 tender joints) who were refractory to MTX treatment (7.5–25 mg weekly, inclusive). The study duration was 38 weeks, containing a 10-week safety followup. Patients were randomized 1:1:1:1:1 to receive CNTO6785 15, 50, 100, or 200 mg every 4 weeks + MTX or placebo + MTX. The primary endpoint was American College of Rheumatology 20 (ACR20) response at Week 16. <h3>Results</h3> There were no significant differences from placebo in the proportion of patients treated with CNTO6785 in the primary endpoint of ACR20 response at Week 16. There were no significant findings in any additional efficacy variables through Week 32. No dose-response relationships or specific patterns were observed in adverse event profiles among CNTO6785 treatment groups. Infections occurred with similar frequency across all groups, and injection site reactions were mild or moderate and did not demonstrate a dose-response relationship. Median serum CNTO6785 concentration increases through Week 38 were about dose-proportional; the incidence of neutralizing antidrug antibodies was 19.4% and was not associated with study drug dose level. <h3>Conclusion</h3> CNTO6785 was well tolerated, but did not demonstrate clinical efficacy in patients with active RA with inadequate response to MTX.
The Creation of The Medical Therapist
Authors: Paul S. Derian
Journal: JAMA (1968)

<h3>To the Editor:—</h3> New programs for the young, needy, and aging are now part of American medicine. With medicaid, medicare, and regional health and proposed neighborhood medical centers, how will the physician staffing be realized? There are, at the last count, 294,072 active physicians in America. Our population exceeds 200 million. In 1963 it was estimated that to maintain the existing ratio of physicians to population, medical school admissions should be doubled in the next decade. If we review the total number of medical schools and graduates from 1946 to 1968, it would be obvious that greater initiative and drastic changes are needed. <h3>Medical Schools Graduates</h3> 1946 78 5,826 1964 85 7,336 1968 99 7,996 In 1910 with the Flexner Report, an improved program for the student began. University associations ultimately became a reality. Uniquely, by structuring medical education the physician was to lessen his contact with the community. In
Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia
Authors: K Giannopoulos, A Dmoszynska, M Kowal, E Wąsik-Szczepanek, A Bojarska-Junak, J Rolinski, H Döhner, S Stilgenbauer, L Bullinger
Journal: Leukemia (2009)
Treatment of ANCA-Associated Vasculitis
Authors: Alfredo N. C. Santana, Telma Antunes, Carmen S. V. Barbas
Journal: JAMA (2007)

To the Editor: Dr Bosch and colleagues conducted a systematic review of treatment of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis, including Wegener granulomatosis. However, their article did not discuss the increased incidence of thromboembolic events in patients with Wegener granulomatosis and the possible role of anticoagulation in these patients. The incidence of thromboembolic events in Wegener granulomatosis is as high as in patients with previous idiopathic venous thromboembolism (7.0 cases/ 100 patient-years vs 7.2 cases/100 patient-years, respectively). Considering that prophylactic use of warfarin is an effective method of preventing thromboembolic events in patients with previous idiopathic venous thromboembolism, it is possible that prophylactic anticoagulation may also have a role in patients with Wegener granulomatosis who have no contraindications to warfarin. This may be especially important during disease activity because 81% of thromboembolic events in persons with active Wegener granulomatosis occur during this phase. However, this would need to be addressed by a randomized clinical trial.
Canonical Transient Receptor Potential 1 Channel Is Involved in Contractile Function of Glomerular Mesangial Cells
Authors: Juan Du, Sherry Sours-Brothers, Rashadd Coleman, Min Ding, Sarabeth Graham, De-Hu Kong, Rong Ma
Journal: Journal of the American Society of Nephrology (2007)

Contractility of mesangial cells (MC) is tightly controlled by [Ca(2+)](i). Ca(2+) influx across the plasma membrane constitutes a major component of mesangial responses to vasoconstrictors. Canonical transient receptor potential 1 (TRPC1) is a Ca(2+)-permeable cation channel in a variety of cell types. This study was performed to investigate whether TRPC1 takes part in vasoconstrictor-induced mesangial contraction by mediating Ca(2+) entry. It was found that angiotensin II (AngII) evoked remarkable contraction of the cultured MC. Downregulation of TRPC1 using RNA interference significantly attenuated the contractile response. Infusion of AngII or endothelin-1 in rats caused a decrease in GFR. The GFR decline was significantly reduced by infusion of TRPC1 antibody that targets an extracellular domain in the pore region of TRPC1 channel. However, the treatment of TRPC1 antibody did not affect the AngII-induced vasopressing effect. Electrophysiologic experiments revealed that functional or biologic inhibition of TRPC1 significantly depressed AngII-induced channel activation. Fura-2 fluorescence-indicated that Ca(2+) entry in response to AngII stimulation was also dramatically inhibited by TRPC1 antibody and TRPC1-specific RNA interference. These results suggest that TRPC1 plays an important role in controlling contractile function of MC. Mediation of Ca(2+) entry might be the underlying mechanism for the TRPC1-associated MC contraction.
Surgeon Judgment and Utility of Transit Time Flow Probes in Coronary Artery Bypass Grafting Surgery
Authors: Jacquelyn Quin, John Lucke, Brack Hattler, Sandeep Gupta, Janet Baltz, Muath Bishawi, G. Hossein Almassi, Frederick L. Grover, Joseph Collins, A. Laurie Shroyer
Journal: JAMA Surgery (2014)

Transit time flow (TTF) probes may be useful for predicting long-term graft patency and assessing grafts intraoperatively in patients undergoing coronary artery bypass grafting (CABG); however, studies of TTF probe use are limited.To examine 1-year graft patency and intraoperative revision rates in patients undergoing CABG based on intraoperative TTF assessment.Retrospective analysis of a multicenter randomized clinical trial conducted at 18 Veterans Affairs hospitals using the Randomized On/Off Bypass (ROOBY) Trial data set. Of the original 2203 patients undergoing CABG surgery with or without cardiopulmonary bypass from February 1, 2002, through May 31, 2008, we studied a subset of 1607 who underwent TTF probe analysis of 1 or more grafts during surgery.Use of TTF probes to assess graft flow and pulsatility index (PI) values. The decision to revise a graft was based on the judgment of the attending surgeon.Rates of 1-year FitzGibbon grade A patency and intraoperative revision were compared based on TTF measurements (<20 [low flow] vs ≥20 mL/min [normal flow]) and PI values (<3, 3-5, and >5).We measured TTF and/or PI in 2738 grafts, and 1-year patency was determined in 1710 (62.5%) of these grafts. FitzGibbon grade A patency occurred significantly less often in grafts with a TTF with low flow (259 of 363 [71.3%]) than in those with normal flow (1174 of 1347 [87.2%]; P < .01). FitzGibbon grade A patency was also inversely correlated with increasing PI values, as found in 936 of 1093 grafts (85.6%) with a PI less than 3, 136 of 182 grafts (74.7%) with a PI of 3 to 5, and 91 of 134 grafts (67.9%) with a PI greater than 5 (P ≤ .01). Intraoperative graft revision was more frequent in grafts with low flow (44 of 568 [7.7%]) than in those with normal flow (8 of 2170 [0.4%]; P < .01). Graft revision was also more frequent as PI increased (12 of 1827 [0.7%] with a PI <3, 9 of 307 [2.9%] with a PI 3-5, and 9 of 155 [5.8%] with a PI >5; P < .01).Intraoperative TTF probe data may be helpful in predicting long-term patency and in the decision of whether to revise a questionable graft for patients undergoing CABG surgery.