tbuckley/cabot-search huggingface dataset:
Multiple agminate Spitz naevi: Review of the literature and report of a case with distinctive immunohistological features
Authors: H. HAMM, R. HAPPLE, EVA-BETTINA BROCKER
Journal: British Journal of Dermatology (1987)

We describe a 13-year-old girl with multiple pigmented nodules and plaques arranged in a cluster in the right lumbar region, which had developed since infancy. Eleven of 15 lesions which were examined histologically were found to be Spitz naevi. The remaining four lesions were compound naevocellular naevi, and two of them showed focal dysplasia. Eight Spitz naevi were investigated immunohistologically with monoclonal antibodies against HLA-antigens and malignancy-associated melanocytic antigens which are rarely present in common naevi. Naevus cells in all lesions expressed HLA-ABC antigens, but lacked HLA-DR antigens in seven of the eight lesions. All naevi were positive for 'constitutive' (KG-6-56) and 'early' (K-1-2) markers of naevomelanocytic cells. In five of the eight Spitz naevi, at least one of the three malignancy-associated melanocytic antigens PAL-M1, A-1-43 and A-10-33 was found. The expression of malignancy-associated antigens in multiple agminate Spitz naevi is at variance with their benign clinical course.
Unorthodox internal fixation of bone lesions in myelomatosis.
Authors: A Kubie, P I Busfield, R P Britt
Journal: BMJ (1987)

Une observation: myelomatose avec lesions importantes de l'humerus et extension de la tumeur aux muscles voisins. La radiotherapie risquant de favoriser les fractures pathologiques, un traitement original est applique: ablation du tissu tumoral par aspiration, puis injection dans l'os de ciment orthopedique. Resultats satisfaisants
Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities.
Authors: G L Spitalny, E A Havell
Journal: The Journal of Experimental Medicine (1984)

Fusion of rat immune spleen cells with mouse myeloma cells resulted in the formation of a stable hybridoma that secretes monoclonal antibody (MAb) directed against murine gamma interferon ( MuIFN -gamma). This MAb specifically neutralized the antiviral activity of a variety of MuIFN -gamma preparations, including a sample produced by recombinant DNA technologies. In contrast, the antiviral activities of a mixture of MuIFN -alpha plus MuIFN -beta, as well as those of rat or human IFN-gamma, were not neutralized by this antibody. The ability of the MAb to inhibit lymphokine-induced macrophage activation was also tested. It was found that in relation to the quantity of antibody needed to completely neutralize antiviral activity, much higher concentrations of MAb were required to abolish the capacity of lymphokine preparations to induce macrophage tumoricidal activity in vitro. The MAb was also coupled to cyanogen bromide-activated Sepharose beads and used as an immunoadsorbent. By reacting lymphokines with MAb coupled to an insoluble matrix, it was possible to show that this immobilized antibody completely and specifically removed from the lymphokine preparations the ability both to invoke macrophage tumoricidal activity and to mediate antiviral activity.
[670] A NEW SUBSTRATE FACILITATES THE DETECTION OF AUTOIMMUNE HEPATITIS SPECIFIC ANTI-SMOOTH MUSCLE ANTIBODIES
Authors: D.P. Bogdanos, L. Komorowski, C. Liaskos, E.T. Davies, G. Mieli-Vergani, G.N. Dalekos, D. Vergani
Journal: Journal of Hepatology (2007)
Regulated Payments for Living Kidney Donation: An Empirical Assessment of the Ethical Concerns
Authors: Scott D. Halpern
Journal: Annals of Internal Medicine (2010)

Background: Although regulated payments to encourage living kidney donation could reduce morbidity and mortality among patients waiting for a kidney transplant, doing so raises several ethical concerns. Objective: To determine the extent to which the 3 main concerns with paying kidney donors might manifest if a regulated market were created. Design: Cross-sectional study of participants' willingness to donate a kidney in 12 scenarios. Setting: Regional rail and urban trolley lines in Philadelphia County, Philadelphia, Pennsylvania. Participants: Of 550 potential participants, 409 completed the questionnaire (response rate, 74.4%); 342 of these participants were medically eligible to donate. Intervention: Across scenarios, researchers experimentally manipulated the amount of money that participants would receive, the participants' risk for subsequently developing kidney failure themselves, and who would receive the donated kidney. Measurements: The researchers determined whether payment represents an undue inducement by evaluating participants' sensitivity to risk in relation to the payment offered or an unjust inducement by evaluating participants' sensitivity to payment as a function of their annual income. The researchers also evaluated whether introducing payment would hinder altruistic donations by comparing participants' willingness to donate altruistically before versus after the introduction of payments. Results: Generalized estimating equation models revealed that participants' willingness to donate increased significantly as their risk for kidney failure decreased, as the payment offered increased, and when the kidney recipient was a family member rather than a patient on a public waiting list (P < 0.001 for each). No statistical interactions were identified between payment and risk (odds ratio, 1.00 [95% CI, 0.96 to 1.03]) or between payment and income (odds ratio, 1.01 [CI, 0.99 to 1.03]). The proximity of these estimates to 1.0 and narrowness of the CIs suggest that payment is neither an undue nor an unjust inducement, respectively. Alerting participants to the possibility of payment did not alter their willingness to donate for altruistic reasons (P = 0.40). Limitation: Choices revealed in hypothetical scenarios may not reflect real-world behaviors. Conclusion: Theoretical concerns about paying persons for living kidney donation are not corroborated by empirical evidence. A real-world test of regulated payments for kidney donation is needed to definitively show whether payment provides a viable and ethical method to increase the supply of kidneys available for transplantation. Primary Funding Source: None.
Mining Functional Gene Modules Linked with Rheumatoid Arthritis Using a SNP-SNP Network
Authors: Lin Hua, Hui Lin, Dongguo Li, Lin Li, Zhicheng Liu
Journal: Genomics Proteomics & Bioinformatics (2012)

Abstract The identification of functional gene modules that are derived from integration of information from different types of networks is a powerful strategy for interpreting the etiology of complex diseases such as rheumatoid arthritis (RA). Genetic variants are known to increase the risk of developing RA. Here, a novel method, the construction of a genetic network, was used to mine functional gene modules linked with RA. A polymorphism interaction analysis (PIA) algorithm was used to obtain cooperating single nucleotide polymorphisms (SNPs) that contribute to RA disease. The acquired SNP pairs were used to construct a SNP-SNP network. Sub-networks defined by hub SNPs were then extracted and turned into gene modules by mapping SNPs to genes using dbSNP database. We performed Gene Ontology (GO) analysis on each gene module, and some GO terms enriched in the gene modules can be used to investigate clustered gene function for better understanding RA pathogenesis. This method was applied to the Genetic Analysis Workshop 15 (GAW 15) RA dataset. The results show that genes involved in functional gene modules, such as CD160 (rs744877) and RUNX1 (rs2051179), are especially relevant to RA, which is supported by previous reports. Furthermore, the 43 SNPs involved in the identified gene modules were found to be the best classifiers when used as variables for sample classification.
114 RESULTS OF A 10-YEAR MULTICENTER EXPERIENCE IN SPLIT-LIVER TRANSPLANTATION IN AN ITALIAN TRANSPLANT PROGRAM
Authors: T.M. De Feo, M. Colledan, E. Andorno, L.G. De Carlis, U. Cillo, G. Rossi, U. Baccarani, E. Regalia, M. Donataccio, A. Risaliti, M. Guizzetti, D. Pinelli, A. Slim, A. Brolese, D. Testasecca, R. Torelli, M. Scalamogna
Journal: Journal of Hepatology (2008)
Increased urinary excretion of 1.4‐methyl‐imidazoleacetic acid in patients with atopic dermatitis
Authors: R. Lindskov, A. Wærsted, O. Baadsgaard, I. Søndergaard
Journal: Allergy (1988)

To investigate whether the overall histamine turnover is increased in patients with atopic dermatitis, without respiratory disease, the urinary excretion of the main histamine metabolite 1,4‐methyl‐imidazoleacetic acid (MIAA) was examined in 23 patients and in 23 age‐ and sex‐matched non‐atopic controls. The patients excreted significantly more MIAA than the controls. One third of the patients however, showed MIAA excretion within or below normal range. The MIAA excretion was neither correlated to the severity of the eczema nor to the total serum IgE. It was concluded that histamine does not play a significant role in the pathophysiology of atopic dermatitis, and that the great variation in MIAA excretion, and hence the histamine turnover, reflected the spectrum of histamine releasability in the patients.
Just What the Doctor Ordered
Authors: R. Scott, J. A. D. Anderson, A. Cartwright
Journal: BMJ (1960)

CASE OF TEMPORAL ARTERITIS MEDIALJSRNAL 293almost certainly suffered a diffuse enlargement of his aorta.I think it is only coincidence that your diagnosis of " dissecting " aneurysm instead of "dilating" aneurysm is correct.WHIEN TO SUSPECT DISSECTION Dr. GOODWIN: One of the difficulties here, I think, and one which is not uncommon, is the fact that when you have hypertrophy of both ventricles the cardiographic diagnosis of infarction may be very difficult.It may be obscured, or it may be counterfeited.On looking through these tracings it is clear, as Dr. Cope has said, that this man never had unequivocal evidence of myocardial infarction.He undoubtedly had myocardial damage and biventricular hypertrophy.That is why I was interested in whether his right ventricle also was enlarged.I think a guiding principle upon which we should work is that, if somebody who is hypertensive has rather atypical chest pain, and a cairdiogram which is no, absolutely diagnostic of cardiac infarction, he may well have a dissection.Dr. COPE: I think we ought to put on record the actual facts about the anticoagulant therapy.I see from the treatment sheets that he was given heparin for one day and part of the second day and then the treatment was cancelled.Two or three weeks later, he was again ordered heparin, presumably for one of these subsequentattacks, but it was deleted and not given.So in fact it was not more than a cotuple of days of anticoagulant therapy, but it might have b.-n an aetiological factor nevertheless.We are grateful to Dr.
Were Eli Lilly Unaware of This Study?
Authors: Aasa Reidak
Journal: PLoS Medicine (2006)

Because of the nature of the analysis used in this study [1], no conclusion is possible.There are plenty of examples in the literature demonstrating the "ecological fallacy".Studies such as this have very little utility other than to generate hypotheses.I tend to think that this association is a marker for greater recognition and treatment for depression.However, it's a brave epidemiologist who would draw any conclusions at all from an ecological association such as this where the outcome is relatively rare.
Aspects of Plastic Surgery: Other Congenital Abnormalities
Authors: J. R. Cobbett
Journal: BMJ (1974)

The plastic surgeon is not a miracle worker, as so many of his patients believe. Nevertheless, he can do much to minimize the functional and cosmetic effect of many congenital deformities. If a moral can be drawn from this article it must be that the plastic surgeon should be given an early opportunity to see and assess the patients described here, if only to ease the anxiety in the minds of their parents by appropriate reassurance and discussion.
988 S-NITROSO-N-ACETYLCYSTEINE (SNAC), A NITRIC OXIDE DONOR, MODULATED HEPATIC STELLATE CELLS (HSCS) ACTIVITY: A NEW ANTIFIBROGENIC AGENT
Authors: J.T. Stefano, B. Cogliati, F.S. Oliveira, V.M. Lima, G.F. de Souza, C. Uribe, M.G. de Oliveira, U. Matte, M.L.Z. Dagli, M.R. Álvares-da-Silva, T.R. Silveira, F.J. Carrilho, C.P. Oliveira
Journal: Journal of Hepatology (2010)
Children with Severe Malnutrition: Can Those at Highest Risk of Death Be Identified with the WHO Protocol?
Authors: Kathryn Maitland, James A Berkley, Mohammed Shebbe, Norbert Peshu, Michael English, Charles R. J. C Newton
Journal: PLoS Medicine (2006)

With strict adherence to international recommended treatment guidelines, the case fatality for severe malnutrition ought to be less than 5%. In African hospitals, fatality rates of 20% are common and are often attributed to poor training and faulty case management. Improving outcome will depend upon the identification of those at greatest risk and targeting limited health resources. We retrospectively examined the major risk factors associated with early (<48 h) and late in-hospital death in children with severe malnutrition with the aim of identifying admission features that could distinguish a high-risk group in relation to the World Health Organization (WHO) guidelines.Of 920 children in the study, 176 (19%) died, with 59 (33%) deaths occurring within 48 h of admission. Bacteraemia complicated 27% of all deaths: 52% died before 48 h despite 85% in vitro antibiotic susceptibility of cultured organisms. The sensitivity, specificity, and likelihood ratio of the WHO-recommended "danger signs" (lethargy, hypothermia, or hypoglycaemia) to predict early mortality was 52%, 84%, and 3.4% (95% confidence interval [CI] = 2.2 to 5.1), respectively. In addition, four bedside features were associated with early case fatality: bradycardia, capillary refill time greater than 2 s, weak pulse volume, and impaired consciousness level; the presence of two or more features was associated with an odds ratio of 9.6 (95% CI = 4.8 to 19) for early fatality (p < 0.0001). Conversely, the group of children without any of these seven features, or signs of dehydration, severe acidosis, or electrolyte derangements, had a low fatality (7%).Formal assessment of these features as emergency signs to improve triage and to rationalize manpower resources toward the high-risk groups is required. In addition, basic clinical research is necessary to identify and test appropriate supportive treatments.
Three steps to rational imagining?
Authors: Jennifer Church
Journal: Behavioral and Brain Sciences (2007)

Abstract Ruth Byrne presents a three-step argument to the conclusion that counterfactual imagining is rational. Insofar as this argument is valid, the conclusion is weaker than it seems. More importantly, it does not represent the central contributions of this book – contributions that, if anything, point instead to what is ir rational about counterfactual imagining.
Abstract A18: Mouse models of autochthonous cancer to study local immune subversion.
Authors: Ali Bransi, Hideo Yagita, Alexander Knuth, Maries van den Broek
Journal: Cancer Research (2013)

Abstract The tumor environment delivers suppressive signals to the immune system, which impair the effector function of tumor-infiltrating lymphocytes. The identity of these signals, their targets and their mode of action, however, are largely unresolved. We use TRAMP mice, a well-known autochthonous murine model for prostate cancer, to study the interaction of the adaptive immune system and cancer cells in order to investigate which cell types and molecules are crucial in deviating immune surveillance. Tumorigenesis in TRAMP mice is driven by SV40 large T (SV40LT), which allows monitoring of specific CD8 T cell responses to the tumor. We analyzed quantitative and qualitative aspects of the tumor-specific T cell response in the spleen, the draining and non-draining lymph nodes and in the tumor of TRAMP mice. Interestingly, this mouse model shows CD8 T cell tolerance towards epitope IV but not epitope I of SV40LT when infected with recombinant vaccinia viruses expressing these epitopes. However, when transferring TCR transgenic CD8 T cells specific for epitope I, we observed rapid local and peripheral immune subversion of adoptively transferred cells in tumor-bearing animals. Homing and proliferation were not affected, but effector functions of these cells were greatly impaired. Furthermore, this immunosuppression was more severe locally at the tumor site than in the periphery. When using a combination of blocking antibodies for co-inhibitory molecules (PD-1, CTLA-4 and TIM-3), we could restore to some extent the function of transferred cells in the periphery, but not at the tumor site. In parallel, we are in the process of generating an inducible CreERT/LoxP-based model to express the immunologically well-characterized oncogene SV40LT with the luciferase in a tissue specific fashion. This model will allow sensitive detection of arising tumors and precise dissection of tumor-specific immunity over time. By comparing fundamentally different target tissues, we may find mechanisms that are active in every malignancy and some that are organ-specific. Citation Format: Ali Bransi, Hideo Yagita, Alexander Knuth, Maries van den Broek. Mouse models of autochthonous cancer to study local immune subversion. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; Dec 2-5, 2012; Miami, FL. Philadelphia (PA): AACR; Cancer Res 2013;73(1 Suppl):Abstract nr A18.
Sedation Interruption for Mechanically Ventilated Patients
Authors: Benjamin T. Galen, Mark D. Siegel
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Population screening for coeliac disease in primary care by district nurses using a rapid antibody test: diagnostic accuracy and feasibility study
Authors: Ilma R Korponay-Szabó, Katalin Szabados, Jánosné Pusztai, Katalin Uhrin, Éva Ludmány, Éva Nemes, Katri Kaukinen, Anikó Kapitány, Lotta Koskinen, Sándor Sipka, Anikó Imre, Markku Mäki
Journal: BMJ (2007)

<b>Objective</b> To evaluate the feasibility and diagnostic accuracy of screening for coeliac disease by rapid detection of IgA antibodies to tissue transglutaminase performed in primary care. <b>Design </b>District nurses screened 6 year old children using rapid antibody testing of finger prick blood. They also collected capillary blood samples for laboratory determination of IgA and IgG antibodies to endomysium and IgA antibodies to tissue transglutaminase. Children with positive rapid test results were directly sent for biopsy of the small intestine. <b>Setting </b>Primary care in Jász-Nagykun-Szolnok county, Hungary. <b>Participants</b> 2690 children (77% of 6 year olds living in the county) and 120 nurses. <b>Main outcome measures</b> Positivity for antibodies to endomysium or transglutaminase in the laboratory and coeliac disease confirmed at biopsy. <b>Results</b> 37 children (1.4%, 95% confidence interval 0.9% to 1.8%) had biopsy confirmed coeliac disease. Only five of these children had been diagnosed clinically before screening. Rapid testing had a 78.1% sensitivity (70.0% to 89.3%) and 100% specificity (88.4% to 100%) for a final diagnosis of coeliac disease by biopsy. Sensitivity was 65.1% (50.2% to 77.6%) and specificity was 100% (99.8% to 100%) compared with combined results of IgA and IgG laboratory tests. Trained laboratory workers detected 30 of the 31 newly diagnosed IgA competent patients with the rapid test kit used blindly. Median time to biopsy after a positive rapid test result was significantly shorter (20 days, range 4-148) than after a positive laboratory result (142 days, 70-256; P&lt;0.001). Children with coeliac disease detected at screening were smaller and had worse health status than their peers but they improved on a gluten-free diet. <b>Conclusions</b> A simple rapid antibody test enabled primary care nurses to detect patients with coeliac disease in the community who were not picked up in clinical care. Extra training is needed to improve sensitivity.
Expandable metal stents for tracheal obstruction: permanent or temporary? A cautionary tale.
Authors: C R Hind, R J Donnelly
Journal: Thorax (1992)

An expandable metal stent inserted via a long term tracheostomy successfully relieved life threatening respiratory obstruction due to benign tracheal stenosis. Later the patient9s tracheostomy suction catheter became stuck on the stent and dislodged it. The stent was removed electively, without damaging the trachea, with a rigid biopsy forceps.
Dermoscopic findings in pyogenic granuloma
Authors: P. Zaballos, Á. Llambrich, F. Cuéllar, S. Puig, J. Malvehy
Journal: British Journal of Dermatology (2006)

Background To the best of our knowledge, no specific dermoscopic criteria have been described in the medical literature for the diagnosis of pyogenic granuloma. Objectives To evaluate the morphological findings of pyogenic granuloma under dermoscopic observation. Methods Dermoscopic examination (using the DermLite Foto; 3Gen, LLC, Dana Point, CA, U.S.A.) of 13 patients with pyogenic granulomas was performed to evaluate specific dermoscopic criteria. Results The most frequently occurring dermoscopic features were found to be: reddish homogeneous area (92%), white collarette (85%), 'white rail' lines that intersect the lesion (31%) and ulceration (46%). The results of our study reveal that the absence of specific dermoscopic criteria for other skin tumours and a reddish homogeneous area surrounded by a white collarette are the most frequent dermoscopic pattern in pyogenic granulomas (85%). Conclusions Dermoscopy is a useful tool for improving the recognition of pyogenic granuloma.
Cross-infection in Children's Wards: Report to the British Paediatric Association
Authors: V. D. Allison, R. B. Bourdillon, W. S. Craig, J. Crooks, W. Crosbie, W. Gaisford, W. Gunn, R. Lightwood, J. C. Spence, C. W. Vining, A. G. Watkins
Journal: BMJ (1946)

The term cross-infection is here used to denote any infection acquired by a patient in the hospital environment.Clinically, it is an infection arising during the course of another illness for which the patient was originally admitted to hospital, and may attack the respiratory tract, gastro-intestinal tract, wound, skin, or mucous membrane, or be manifested as one of the specific fevers.Cross-infection is a constant anxiety to all concerned with the hospital care of sick children and infants, the latter parti-