tbuckley/cabot-search huggingface dataset:
The induction of epigenetic regulation of PROS1 gene in lung fibroblasts by gold nanoparticles and implications for potential lung injury
Authors: Cheng-Teng Ng, S. Thameem Dheen, Wai-Cheong G. Yip, Choon-Nam Ong, Boon-Huat Bay, Lin-Yue Lanry Yung
Journal: Biomaterials (2011)
The Sulfonylurea Receptor, an Atypical ATP-Binding Cassette Protein, and Its Regulation of the K <sub>ATP</sub> Channel
Authors: Michael A. Burke, R. Kannan Mutharasan, Hossein Ardehali
Journal: Circulation Research (2008)

ATP-binding cassette (ABC) proteins are highly conserved and widely expressed throughout nature and found in all organisms, both prokaryotic and eukaryotic. They mediate myriad critical cellular processes, from nutrient import to toxin efflux using the energy derived from ATP hydrolysis. Most ABC proteins mediate transport of substances across lipid membranes. However, there are atypical ABC proteins that mediate other processes. These include, but are not limited to, DNA repair (bacterial MutS), ion transport (cystic fibrosis transmembrane receptor), and mRNA trafficking (yeast Elf1p). The sulfonylurea receptor (SUR) is another atypical ABC protein that regulates activity of the potassium ATP channel (K(ATP)). K(ATP) is widely expressed in nearly all tissues of higher organisms and couples cellular energy status to membrane potential. K(ATP) is particularly important in the regulation of insulin secretion from pancreatic beta-cells and in regulating action potential duration in muscle cells. SUR is indispensable for normal channel function, and mutations in genes encoding SURs increase the susceptibility to diabetes, myocardial infarction, and heart failure. Here, we review the structure and function of ABC proteins and discuss SUR, its regulation of the K(ATP) channel, and its role in cardiovascular disease.
Cryptic Pulmonary Lesions in Workers Occupationally Exposed to Dust Containing Silica
Authors: John E. Craighead
Journal: JAMA (1980)

Fibrotic lesions associated with deposits of crystalline silica were found postmortem in the lungs of 15 granite workers who lacked radiological evidence of pneumoconiosis. All members of this occupational group had been employed in the granite quarrying and monument industry of Vermont since ambient air-dust standards were introduced in 1937. Although particulate silica was not revealed in the lesions by traditional polarization light microscopy, it was identified by scanning electron microscopy in conjunction with backscatter imaging and x-ray spectrometry. The etiologic basis of the fibrotic pulmonary disease would not have been diagnosed without the aid of these modern analytical tools. Exposure to silica-containing dust can result in cryptic pulmonary disease that is not detectable radiologically. In these retrospective postmortem studies, it was not possible to define the distribution of the lesions in the lungs. (<i>JAMA</i>244:1939-1941, 1980)
The hydrogeological role of an aquitard in preventing drinkable water well contamination: a case study.
Authors: G Ponzini, G Crosta, M Giudici
Journal: Environmental Health Perspectives (1989)

Groundwater pollution has become a worrisome phenomenon, mainly for aquifers underlying industrialized areas. In order to evaluate the risk of pollution, a model of the aquifer is needed. Herewith, we describe a quasi-tridimensional model, which we applied to a multilayered aquifer where a phreatic aquifer was coupled to a confined one by means of an aquitard. This hydrogeological scheme is often met in practice and, therefore, models a number of situations. Moreover, aquitards play and important role in the management of natural resources of this kind. The model we adopted contains some approximations: the flow within the aquifers is assumed to be horizontal, whereas leakage is assumed vertical. The effect of some wells drilled in these aquifers is also taken into account. In order to evaluate the leakage fluxes that correspond to different exploitation conditions, we numerically solve a system of quasilinear and time-dependent partial differential equations. This model has been calibrated by the hydrogeological data from a water supply station of the Milan Water Works, where water is polluted by some halocarbons. Our simulations account for several experimental facts, both from the hydrogeological and hydrogeochemical viewpoints. Maxima of computed downward leakage rates are found to correspond with measured pollutant concentration maxima. Other results show how the aquitard can help in minimizing the contamination of drinkable water.
Assessment and management of alcohol use disorders
Authors: E. Day, A. Copello, M. Hull
Journal: BMJ (2015)

#### The bottom line

Alcohol can impact on both the incidence and the course of many health conditions, and nearly 6% of all global deaths in 2012 were estimated to be attributable to its consumption.1 A quarter of the UK adult population drinks alcohol in a way that is potentially or actually harmful to health.2 Between 2002 and 2012 in England the number of episodes where an alcohol related disease, injury, or condition was the primary reason for hospital admission or a secondary diagnosis doubled.3 Despite the large numbers of people drinking alcohol at higher risk levels, a relatively low number access treatment.4 Possible causes for this include missed opportunities to identify problems, limited access to specialist services, and underdeveloped care pathways. International studies have shown that more than 20% of patients presenting to primary care are higher risk or dependent drinkers,5 yet the problem of alcohol is inadequately addressed. This review focuses on practical aspects of the assessment and treatment of alcohol use disorders from the perspective of the non-specialist hospital doctor or general practitioner.

#### Sources and selection criteria

We structured this review around a series of clinical guidelines developed …
Abstract 161: Discovery of novel methylation-based biomarkers for epithelial ovarian cancer using oligonucleotide microarrays
Authors: Pauline de Graeff, Bea Wisman, Rudolf SN Fehrmann, Anne PG Crijns, Gert Jan Meersma, Haukeline H. Volders, Iris Blijdorp, Marian JE Mourits, Harry Hollema, Steven de Jong, Ate GJ van der Zee
Journal: Cancer Research (2010)

Abstract Objective: To improve current screening modalities, additional molecular markers that allow detection of ovarian cancer at an early stage are needed. The aim of the current study was to identify novel methylation-based biomarkers for ovarian cancer. Methods: Genes frequently expressed at low levels were identified by comparing global expression levels from 232 primary ovarian cancers to Universal Reference RNA. Ten genes possessing a CpG island in the promoter region that showed frequent low expression in serous cancers and at least one other histological subtype were selected. The methylation status of candidate genes was verified in 50 sporadic ovarian cancers, 11 hereditary cancers, 13 borderline cancers and 12 cystadenomas using methylation specific PCR (MSP). Results: Three candidate genes (IGFBP1, LIN28 and ZNF582) showed frequent methylation in cancers and were unmethylated in normal leukocyte DNA and human ovarian surface epithelial cells. Promoter methylation of any of the three candidate genes was observed in 88% of stage III/IV cancers and 72% of stage I/II cancers. In contrast, only 9% of hereditary cancers showed evidence of methylation for any of the three genes (p&amp;lt;0.001). IGFBP1 was mainly methylated in stage III/IV cancers (88% vs. 12%, p&amp;lt;0.001), while methylation of LIN28 and ZNF582 was more frequent in stage I/II cancers (8% vs. 44% and 8% vs. 48%, respectively; p&amp;lt;0.05). Conclusions: Using oligonucleotide microarray data, three novel methylation-based biomarkers for sporadic epithelial ovarian cancer were discovered. Further studies should elucidate the methylation status of these genes in larger cohorts of ovarian cancers and investigate their methylation status in serum. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 161.
Territorial song and facial gesture: A language precursor in apes
Authors: Maria Ujhelyi
Journal: Behavioral and Brain Sciences (1999)

The natural communication system of chimpanzees has some unique characteristics rooted in two possible ways of producing call variants in primates. The chimpanzee call repertoire contains variants available to all group members. The transfer presupposes voluntary control and learnability. Chimpanzee vocalization (or its homologue in the common ancestor of chimpanzee and man) seems to represent a real precursor of human language.
Canadian medical journal faces threat from new online rival
Authors: David Spurgeon
Journal: BMJ (2006)

The journal of the Canadian Medical Association, CMAJ , whose editor and deputy editor were dismissed in February in a fight over editorial independence ( BMJ 2006;332: 503), may have to compete with a new open access journal. It is being created by former CMAJ editors, including the deputy editor, Anne-Marie Todkill, and editorial board members.

The new journal, Open Medicine , is a “Canadian health and clinical medicine journal dedicated to furthering integrity, independence, and open access in scholarly publishing,” says its website, http://www.openmedicine.ca/. The site is …
Two Spanish cases of atypical melanosis of the foot, an early stage of acral lentiginous melanoma<i>in situ</i>
Authors: D. Menis, L. Maroñas-Jiménez, J. Rodríguez-Peralto, R. Martin-Llamas, F. Vanaclocha-Sebastián
Journal: British Journal of Dermatology (2014)

Journal Article Two Spanish cases of atypical melanosis of the foot, an early stage of acral lentiginous melanoma in situ Get access D. Menis, D. Menis Department of Dermatology Hospital Doce de Octubre Madrid Spain Search for other works by this author on: Oxford Academic Google Scholar L. Maroñas‐Jiménez, L. Maroñas‐Jiménez Department of Dermatology Hospital Doce de Octubre Madrid Spain Search for other works by this author on: Oxford Academic Google Scholar J. Rodríguez‐Peralto, J. Rodríguez‐Peralto Department of Anatomic Pathology Hospital Doce de Octubre Madrid Spain Search for other works by this author on: Oxford Academic Google Scholar R. Martin‐Llamas, R. Martin‐Llamas Department of Dermatology Hospital Doce de Octubre Madrid Spain Search for other works by this author on: Oxford Academic Google Scholar F. Vanaclocha‐Sebastián F. Vanaclocha‐Sebastián Department of Dermatology Hospital Doce de Octubre Madrid Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 5, 1 May 2015, Pages 1436–1438, https://doi.org/10.1111/bjd.13485 Published: 01 May 2015
Trends in the lifetime risk of COPD exacerbation requiring hospitalisation
Authors: Jesper Lykkegaard, René dePont Christensen, Jesper Rømhild Davidsen, Henrik Støvring, Morten Andersen, Jens Søndergaard
Journal: European Respiratory Journal (2013)

This study aimed to estimate time trends in the lifetime risk of hospitalisation with exacerbation of chronic obstructive pulmonary disease (COPD) in Denmark. During the period from 1994 to 2008, a register-based cohort study was conducted covering each subject in the entire population of Denmark (5.18 million in 2008). Based on previously validated diagnosis codes, all COPD hospitalisations were identified. Individual retrospective review periods of 8 years were used to determine first-time hospitalisations. From year 2002 to 2008, all first-time COPD hospitalised subjects aged ≥30 years were identified. The calculation of lifetime risk was based on age- and sex-specific first-time COPD hospitalisation rates and rates of COPD hospitalisation-free survival, assuming them to be calendar time stationary. The study included 23.9 million person-years of risk time and identified 48 959 first-time COPD hospitalisations. For 30-year-olds in Denmark, the lifetime risk of COPD hospitalisation was 12.0% (95% CI 11.9–12.2) for females and 10.9% (95% CI 10.8–11.1) for males. Trends were generally equal in both sexes. During the period from 2002 to 2008, the rate of first-time COPD hospitalisations decreased, while the survival of never COPD hospitalised subjects increased. In consequence, the lifetime risk of COPD hospitalisation remained constant.
The Health of the Nation.
Authors: S. Ibbotson, P. Watson
Journal: BMJ (1992)

secondary to primary care.Psychiatrists must realise this and start taking the criticisms of their clients and clients to be, the general practitioners in their area, more seriously than they do at present.This question needs to be addressed: if fundholding general practitioners are given the choice between a hospital oriented psychiatry service and other, equally effective, services that may be cheaper and are more flexible, how long before they start putting psychiatrists out of work?
Abstract 3824: Molecular cytogenetic study of a new human rhabdomyosarcoma cell line, HS-RMS-2, with various highly- amplified DNA sequences
Authors: Takahiro Taguchi, Hiroshi Sonobe, Eiji Takaoka, Kunihiro Akimaru, Shuji Sakamoto, Taro Shuin, Masanori Daibata, Akira Tominaga
Journal: Cancer Research (2011)

Abstract Molecular cytogenetic characterization was carried out on a rare pleomorphic type of the human rhabdomyosarcoma cell line, HS-RMS-2, which had been newly established in our laboratory. Conventional G-banding and multicolor-FISH (M-FISH) analyses showed that cells had a complicated chromosomal constitution. Comparative genomic hybridization (CGH) revealed seven highly amplified regions, which suggested a simultaneous amplification of several oncogenes in the same cell. The locations of highly amplified sequences were as follows; 1p36.1-36.2, 1p31-32, 1q21-31, 8q12-21, 8q24-qter, 11q12-13, 12q13-14, and 18q12-22. Reverse FISH painting, using the probe which was regenerated from long marker chromosomes by chromosome microdissection, showed that original sites of four of seven possible genes, which derived from highly amplified regions of chromosomes, located on chromosomes, 1p31-32, 11q13, 12q13 and 18q21. FISH using BAC and cosmid probes (int-2, c-jun and c-myc) which located on 11q12-13, 1p31-32 and 8q24, respectively, demonstrated that those oncogene DNA sequences were clearly amplified. By PCR, amplification of oncogenes of BCL1, BCL2, CHOP, hst-1, int-2, c-jun and c-myc were seened. Also RT-PCR analysis for gene expression showed that the genes located at 1p31-32 and 8q24 were overexpressed. These seven amplified genes may play a important role in the pathogenesis of this rare pleomorphic type of rhabdomyosarcoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3824. doi:10.1158/1538-7445.AM2011-3824
Cilia Dysfunction May Promote Development of Type 2 Diabetes
Authors: Tracy Hampton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clopidogrel pretreatment prior to percutaneous coronary intervention attenuates periprocedural rise of C-reactive protein
Authors: Deepak P. Vivekananthan, Deepak L. Bhatt, Derek P. Chew, Albert W. Chan, David J. Moliterno, Stephen G. Ellis, Eric J. Topol
Journal: Journal of the American College of Cardiology (2003)
Much More Ado About Tobacco Smoke
Authors: Mohinder Partap
Journal: JAMA (1974)

To the Editor.—  I found myself unable to follow Dr. Szasz's logic in his article. He argued, They were not entitled... to proclaim that alcoholism and antisocial personality were genetically determined mental diseases, and at the same time to produce smoke by steadily puffing cigars, cigarettes, and pipes. He concludes, fakery and foolishness [is being foisted]... under the guise of discoveries into the genetic causes and chemical cures of [mental] `illness'. He had, of course, little to comment on the theme and contents of the symposium. It appears that Dr. Szasz found his theory of nonexistence of mental illness threatened and took to nicotinism and rhetorics to dismiss scientific evidence. I wonder if an article like this from a person less known than Dr. Szasz would have been accepted by any reputable journal.
The dose of infused lymphocytes in the autograft directly correlates with clinical outcome after autologous peripheral blood hematopoietic stem cell transplantation in multiple myeloma
Authors: L F Porrata, M A Gertz, S M Geyer, M R Litzow, D A Gastineau, S B Moore, A A Pineda, K L Bundy, D J Padley, D Persky, M Q Lacy, A Dispenzieri, D S Snow, S N Markovic
Journal: Leukemia (2004)
Call for research misconduct agency
Authors: C. White
Journal: BMJ (1998)

The UK needs an independent agency to monitor standards in publication ethics and prevent the growing problem of research misconduct. This is one of the principal recommendations of The COPE Report 1998 , published this week by the Committee on Publication Ethics.

Since its inception in April 1997, the committee has received a steady stream of examples of research fraud, data fabrications, plagiarism, and redundant publication. A substantial number of these are published in the report as anonymised case studies. There are no official data on the scale of the problem, but the report suggests that only a comparatively small …
Prognosis of Right Bundle-Branch Block in Acute Myocardial Infarction
Authors: Lawrence Gould
Journal: JAMA (1972)

Twenty-two of 31 patients with right bundle-branch block (RBBB) following acute myocardial infarction died. Right bundle branch block was present on admission in 21 cases and subsequently appeared in ten cases. Ten of 14 patients (72%) with RBBB and left anterior hemiblock died of a cardiac arrhythmia. Of the 11 patients with RBBB and left posterior hemiblock, seven died of a cardiac arrhythmia and one died of pulmonary emboli (73%, total mortality). Three (60%) of five patients with RBBB died—two with an arrhythmia and one in shock. The one patient with RBBB and prolonged PR interval died of a cardiac arrhythmia.
Spectrum of echocardiographic findings in bacterial endocarditis.
Authors: P Roy, A J Tajik, E R Giuliani, T T Schattenberg, G T Gau, R L Frye
Journal: Circulation (1976)

Forty-seven echocardiograms were obtained in 32 patients with bacterial endocarditis. Preexistent abnormalities were found in 14 patients. In five of them thought to have bacterial endocarditis on normal valves, echocardiography showed mitral stenosis (one), bicuspid aortic valve (two), and prolapse of mitral valve (two). Definite vegetations were seen in 22 patients--on the aortic valve in seven, the mitral valve in 12, and both valves in three. Ten patients had milder changes suggestive but not diagnostic of vegetations. In 12 patients, surgery confirmed the echocardiographic findings. Fourteen had systemic embolic episodes and all had echocardiographic evidence of vegetations. Abnormalities secondary to bacterial endocarditis, other than vegetations, were common. Twenty-one patients had left ventricular volume overload. Ten had a flail posterior leaflet of the mitral valve, three of which were confirmed surgically. Eight had abnormal coarsely fluttering echoes in the left ventricular outflow tract consistent with a prolapsing aortic valve or underlying aortic vegetations; four were confirmed by surgery. Five had signs of severe aortic regurgitation of recent onset (premature mitral valve closure) and all had confirmation by surgery. Echocardiographic abnormalities persisted after successful medical treatment. We conclude that echocardiography is helpful in patients with bacterial endocarditis. It permits recognition of unsuspected preexistent lesions and the characteristic vegetations, as well as the extent and nature of valvular damage secondary to bacterial endocarditis. However, echocardiography does not differentiate between active and healed lesions.
The Angiocardiographic Diagnosis of Valvular Stenosis
Authors: MURRAY G. BARON
Journal: Circulation (1971)

The angiocardiographic diagnosis of valvular stenosis depends on demonstrating a limitation in the motion of the cusps or leaflets so that the valve cannot open completely. In general, this technique is best for study of the pulmonic and aortic valves although a fairly accurate evaluation of the pliability or rigidity of a stenotic mitral valve can also be made. The normal valve cusps are usually not seen during systole, but, when they are stenotic, they assume a domelike configuration, bulging in the direction of blood flow. This is easily seen and is quite characteristic. Despite the degree of stenosis, so long as the cusps or leaflets are not severely fibrotic, they can appear normal in their diastolic position.
Semantic redintegration: Ecological invariance
Authors: Stephen E. Robbins
Journal: Behavioral and Brain Sciences (2008)

Abstract In proposing that their model can operate in the concrete, perceptual world, Rogers &amp; McClelland (R&amp;M) have not done justice to the complexities of the ecological sphere and its invariance laws. The structure of concrete events forces a different framework, both for retrieval of events and concepts defined across events, than that upon which the proposed model, rooted in essence in the verbal learning tradition, implicitly rests.
371 ATROPINE FOR THE PREVENTION OF CARDIAC DYSRHYTHMIAS IN PATIENTS WITH HEPATOCELLULAR CARCINOMA UNDERGOING PERCUTANEOUS ETHANOL INSTILLATION: A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND TRIAL
Authors: A. Ferlitsch, M. Schmid, H. Schmidinger, M. Homoncik, J. Pleiner-Duxneuner, G. Ulbrich, A. Gangl, M. Peck-Radosavljevic
Journal: Journal of Hepatology (2008)