Antibodies and Clinical Relapse of Murine Typhus Fever Following Early Chemotherapy
Authors: CHARLES L. WISSEMAN
Journal: Annals of Internal Medicine (1962)

Article1 November 1962Antibodies and Clinical Relapse of Murine Typhus Fever Following Early ChemotherapyCHARLES L. WISSEMAN JR., M.D., WILLIAM H. WOOD JR., M.D., ANTONIO R. NORIEGA, M.D., MARTHA E. JORDAN, PH.D., DOLORES J. RILL, B.A.CHARLES L. WISSEMAN JR., M.D.Search for more papers by this author, WILLIAM H. WOOD JR., M.D.Search for more papers by this author, ANTONIO R. NORIEGA, M.D.Search for more papers by this author, MARTHA E. JORDAN, PH.D.Search for more papers by this author, DOLORES J. RILL, B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-5-743 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInsecticides, rodenticides, immunoprophylactic measures, and chemotherapeutic agents have combined to minimize the present-day importance of typhus fevers as a cause of death or incapacitation. It is only natural, perhaps, that a state of apathy now exists among medical scientists in this country with regard to the need for further study of diseases such as these that appear to be waning. Yet, epidemic typhus has repeatedly influenced human destiny in a most dramatic fashion (1) and its lesser relative, murine typhus, has had essentially world-wide distribution. Historical records of human behavior and the present world political climate give little reassurance that...References1. ZINSSER H: Rats, Lice and History, Atlantic Monthly Press, Little, Brown and Company, Boston, 1934, p. 1. Google Scholar2. FOXMONTOYAJORDANCORNEJO UBILLUSGARCIAESTRADAGELFAND JPJAMEJRJLMAHM: Immunization of man against epidemic typhus by infection with avirulent Rickettsia prowazeki (Strain E). V. A brief review and observations during a 3½ year period as to the occurrence of typhus among vaccinated and control populations in the Peruvian Andes. Arch. Inst. Pasteur Tunis 36: 449, 1959. Google Scholar3. SMADEL JE: Influence of antibiotics on immunologic responses in scrub typhus. Amer. J. Med. 17: 246, 1954. CrossrefMedlineGoogle Scholar4. SMADEL JE: Rickettsial diseases, in Diagnostic Procedures for Virus and Rickettsial Diseases, 2d Ed., American Public Health Association, New York, 1956, p. 513. Google Scholar5. CHANGSNYDERMURRAY SJCES: A serologically active erythrocyte sensitizing substance from typhus rickettsiae. II. Serological properties. J. Immunol. 70: 215, 1953. MedlineGoogle Scholar6. TOPPINGBENGTSONHENDERSONSHEPARDSHEAR NHIARGCCMJ: Studies of Typhus Fever, National Institutes of Health Bulletin No. 183, 1945. Google Scholar7. PAYNESHARPKNAUDT EHEAJA: Treatment of epidemic typhus with Chloromycetin. Trans. Roy. Soc. Trop. Med. Hyg. 42: 163, 1948. CrossrefGoogle Scholar8. SMADELLEONLEYVARELA JEAPHLG: Chloromycetin in the treatment of patients with typhus fever. Proc. Soc. Exp. Biol. Med. 68: 12, 1948. CrossrefMedlineGoogle Scholar9. BLUMBERGDOANEWEISS NJCLB: Brill's disease. Report of three cases with aureomycin treatment in two. New Engl. J. Med. 241: 479, 1949. CrossrefMedlineGoogle Scholar10. KNIGHTRUIZ-SANCHEZRUIZ-SANCHEZMCDERMOTT VFAW: Aureomycin in typhus and brucellosis. Amer. J. Med. 6: 407, 1949. CrossrefMedlineGoogle Scholar11. SCHOENBACH EB: Aureomycin therapy of recrudescent epidemic typhus (Brill's disease). JAMA 139: 450, 1949. CrossrefMedlineGoogle Scholar12. CUTILIERO J: Consideracoes acerca do tratamento das rickettsioses exanthematicas pela aureomicina. Gaz. Med. Port. 3: 337, 1950. MedlineGoogle Scholar13. DANASEBAGCOHENBORSONI RAJG: A propos de quelques cas de typhus exanthematique. Le traitement par la chloromycetine. Bull. Soc. Med. Hop. Paris 21/22: 1073, 1950. Google Scholar14. D'IGNAZZIOBENETAZZO CB: Aggiornamento e critica terapia del dermotifo. Arch. Ital. Sci. Med. Trop. 31: 733, 1950. Google Scholar15. D'IGNAZZIOTHERMINE CL: La chloromycetina nella terapia del dermotifo in Etiopia (nota clinica). Arch. Ital. Sci. Med. Trop. 31: 638, 1950. Google Scholar16. FRANK HR: Der geegenwartige stand der chemotherapie der rickettsiosen. Zbl. Bakt. (Orig.) 148: 23, 1950. Google Scholar17. LEYWOODWARDSMADEL HLTEJE: Chloramphenicol (Chloromycetin) in the treatment of murine typhus. JAMA 143: 217, 1950. CrossrefMedlineGoogle Scholar18. PFEIFFER DH: Louse and flea-borne typhus. Cerebrospinal fluid findings and the response to aureomycin and Chloromycetin. S. Afr. Med. J. 24: 111, 1950. Google Scholar19. RUIZ-SANCHEZ F: El tratamiento del tifo exantematico con acido para amino-benzoico, aureomycina, y cloromicetina. Medicina (Mex.) 30: 3, 1950. Google Scholar20. KILLOUGHMAGILL JHGB: Terramycin in epidemic typhus, amebic dysentery and typhoid. JAMA 147: 1737, 1951. CrossrefMedlineGoogle Scholar21. KNIGHTRUIZ-SANCHEZ VF: Treatment of endemic and epidemic typhus with antibiotics. Ann. N. Y. Acad. Sci. 55: 992, 1952. CrossrefMedlineGoogle Scholar22. LEYSMADEL HLJE: Antibiotic therapy of rickettsial diseases. Antibiot. Chemother. (Basel) 4: 792, 1954. Google Scholar23. WOODWARD TE: Therapy of rickettsial diseases with a discussion of chemoprophylaxis. Arch. Inst. Pasteur Tunis 36: 507, 1959. Google Scholar24. TIGERTT WD: Studies on Q fever in man, in Symposium on Q Fever, Medical Science Publication No. 6, Walter Reed Army Institute of Research, United States Government Printing Office, Washington, D. C., 1959, p. 39. Google Scholar25. MAXCY KF: Clinical observations on endemic typhus (Brill's disease) in southern United States. Public Health Rep. 41: 1213, 1926. CrossrefMedlineGoogle Scholar26. STUARTPULLEN BMRL: Endemic (murine) typhus fever: clinical observations of 180 cases. Ann. Intern. Med. 23: 520, 1945. LinkGoogle Scholar27. MILLERBEESON ESPB: Murine typhus fever. Medicine 25: 1, 1946. CrossrefMedlineGoogle Scholar28. WOODWARDWISSEMAN TECL: Chloromycetin (chloramphenicol), Antibiotics Monographs No. 8, Medical Encyclopedia, Inc., New York, 1958, p. 46. Google Scholar29. SPINK WW: The Nature of Brucellosis, University of Minnesota Press, Minneapolis, 1956, p. 1. Google Scholar30. BOZEMANHOPPSDANAUSKASJACKSONSMADEL FMHEJXEBJE: Study on the growth of rickettsiae. I. A tissue culture system for quantitative estimations of Rickettsia tsutsugamushi. J. Immunol. 76: 475, 1956. MedlineGoogle Scholar31. HOPPSJACKSONDANAUSKASSMADEL HEEBJXJE: Study on the growth of rickettsiae. IV. Effect of chloramphenicol and several metabolic inhibitors on the multiplication of Rickettsia tsutsugamushi in tissue culture cells. J. Immunol. 82: 172, 1959. MedlineGoogle Scholar32. LEYDIERCKSPATERSONSMADELWISSEMANTRAUB HLFHPYJECLR: Immunization against scrub typhus. IV. Living Karp vaccine and chemoprophylaxis in volunteers. Amer. J. Hyg. 56: 303, 1952. MedlineGoogle Scholar33. SMADELLEYDIERCKSCAMERON JEHLFHJA: Persistence of Rickettsia tsutsugamushi in tissues of patients recovered from scrub typhus. Amer. J. Hyg. 56: 294, 1952. MedlineGoogle Scholar34. PARKERMENONMERIDETHSNYDERWOODWARD RTPGAMMJTE: Persistence of Rickettsia rickettsii in a patient recovered from Rocky Mountain spotted fever. J. Immunol. 73: 383, 1954. MedlineGoogle Scholar35. PRICEEMERSONNAGELBLUMBERGTALMADGE WHHHRS: Ecological studies on the interepidemic survival of louse-borne epidemic typhus fever. Amer. J. Hyg. 67: 154, 1958. MedlineGoogle Scholar36. WOLBACH SB: The pathology of the rickettsial diseases of man, in Rickettsial Diseases of Man, American Association for the Advancement of Science, Washington, D. C., 1948, p. 118. Google Scholar37. WISSEMANFRATTOFIGELMAN CLCL: Unpublished observations. Google Scholar38. CLARKEFOX DHJP: The phenomenon of in vitro hemolysis produced by the rickettsiae of typhus fever, with a note on the mechanism of rickettsial toxicity in mice. J. Exp. Med. 88: 25, 1948. CrossrefMedlineGoogle Scholar39. CASTANEDASILVA MRGR: Estudios fundementales sobre allergia en el tifo, in Memorias de la Primera Reunion Interamericana del Tifo, Octobre 1945, Mexico. Google Scholar40. LEON AP: Precipitacion de sueros anti-tifo por la orina de enfermos de tifo exantematico. Una nueva reaccion serologica para el diagnostico del tifo. Rev. Inst. Salubr. Enferm. Trop. 3: 201, 1942. Google Scholar41. SMORODINTSEFFFRADKINA AARV: Slide agglutination test for rapid diagnosis of preeruptive typhus fever. Proc. Soc. Exp. Biol. Med. 56: 93, 1944. CrossrefGoogle Scholar42. DOWNSFEVURLYMEYER CMJMM: Studies on hemagglutination inhibition phenomena. I. The presence of inhibiting antigen in typhus-infected animals. J. Immunol. 75: 35, 1955. MedlineGoogle Scholar43. FLECKPORATEVENCHIKKLINGBERG LSZMA: The renal excretion of specific microbial substances during the course of infection with murine typhus rickettsiae. Amer. J. Hyg. 72: 351, 1960. MedlineGoogle Scholar44. DIXONVAZQUEZWEIGLECOCHRANE FJJJWOCG: Pathogenesis of serum sickness. Arch. Path. 65: 18, 1958. Google Scholar45. DIXON FJ: The pathogenic significance of antigen-antibody complexes, in First International Symposium on Immunopathology, 1958, ed. by Grabar, P., and Miescher, P., Benno Schwabe and Company, Basel/Stuttgart, 1959, p. 299. Google Scholar46. GREENGOLDBERG HB: The action of antibody and complement on mammalian cells. Ann. N. Y. Acad. Sci. 87: 352, 1960. CrossrefMedlineGoogle Scholar47. MOSESATKINS JME: Studies on tuberculin fever. II. Observations on the role of endogenous pyrogen in tolerance. J. Exp. Med. 114: 939, 1961. CrossrefMedlineGoogle Scholar48. ABRIKOSOV AI: Pathologic anatomy of typhus fever. Sovietskaja Medicina Kazan nos. 23-24, 8, 1941. (Trop. Dis. Bull. 40: 764, 1943.) Google Scholar49. WALTHER G: Nachkrankheiten in der Fleckfieber-Rekönvaleszens. Klin. Wschr. 21: 269, 1932. CrossrefGoogle Scholar50. ALLENSPITZ ACS: A comparative study of the pathology of scrub typhus (tsutsugamushi disease) and other rickettsial diseases. Amer. J. Path. 21: 603, 1945. MedlineGoogle Scholar51. HARRELL GT: Rocky Mountain spotted fever. Medicine 28: 333, 1949. CrossrefMedlineGoogle Scholar52. BUCCO G: Ricerche istologiche sulle lesioni meningee nel dermotifo. Acta Med. Ital. Mal. Infett. 6: 156, 1951. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES L. WISSEMANJR., M.D.; WILLIAM H. WOODJR., M.D.; ANTONIO R. NORIEGA, M.D.; MARTHA E. JORDAN, PH.D.; DOLORES J. RILL, B.A.Affiliations: Baltimore, MarylandFrom the Department of Microbiology, University of Maryland School of Medicine, Baltimore, Maryland.Drs. Noriega and Wood are trainees in rickettsiology and virology under training grant 2E-16, National Institute of Allergy and Infectious Diseases, National Institutes of Health.Requests for reprints should be addressed to Charles L. Wisseman, Jr., M.D., Department of Microbiology, University of Maryland School of Medicine, 31 South Greene Street, Baltimore 1, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLaboratory-acquired Scrub Typhus and Murine Typhus Infections: The Argument for a Risk-based Approach to Biosafety Requirements for Orientia tsutsugamushi and Rickettsia typhi Laboratory ActivitiesA Prospective, Open-label, Randomized Trial of Doxycycline Versus Azithromycin for the Treatment of Uncomplicated Murine TyphusRelapse of rickettsial Mediterranean spotted fever and murine typhus after treatment with chloramphenicolCase Report: Serologic Evidence of Acute Murine Typhus Infection in a Patient with Culture-Negative EndocarditisCharacteristics of Rickettsia mooseri infection of normal and immune miceUse of a sensitive microplate enzyme-linked immunosorbent assay in a retrospective serological analysis of a laboratory population at risk to infection with typhus group rickettsiaeMechanisms of Immunity in Typhus Infections II. Multiplication of Typhus Rickettsiae in Human Macrophage Cell Cultures in the Nonimmune System: Influence of Virulence of Rickettsial Strains and of ChloramphenicolLaboratory-Acquired Typhus FeversLARRY J. WRIGHT, M.D., LEWELLYS F. BARKER, M.D., IRA D. MICKENBERG, M.D., SHELDON M. WOLFF, M.D., F.A.C.P.The Status of Immunization in 1963Infectious Diseases: Annual Review of Significant Publications 1 November 1962Volume 57, Issue 5Page: 743-754KeywordsChemotherapyChloramphenicolClinical microbiologyFeversInfectious diseasesInsecticideMicrobiologyScientistsTyphusVirology ePublished: 1 December 2008 Issue Published: 1 November 1962 PDF downloadLoading ...