Response to Sodium Fluoride in Severe Primary Osteoporosis
Authors: Clayton Rich, Peter Ivanovich
Journal: Annals of Internal Medicine (1965)

Case Studies1 December 1965Response to Sodium Fluoride in Severe Primary OsteoporosisCLAYTON RICH, M.D., PETER IVANOVICH, M.D.CLAYTON RICH, M.D., PETER IVANOVICH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-1069 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been shown from epidemiological studies that a moderate intake of fluoride will eventually cause osteosclerosis that is not associated with significant morbidity except in the most extreme cases (1-3). Because of this and because it is reasonable to suppose that any measure that substantially increases bone mass will reverse the course of osteoporosis, we evaluated sodium fluoride several years ago as a possible form of treatment of this disease (4). In this early work and in recently published studies (5), we found that most patients with osteoporosis or Paget's disease retained calcium, and no significant toxic effects were...References1. ROHOLM K: Fluorine Intoxication: A Clinical-hygienic Study, H. K. Lewis, London, 1937. Google Scholar2. SINGHJOLLYBANSALMATHUR ASSBCCC: Endemic fluorosis. Epidemiological, clinical and biochemical study of chronic fluorine intoxication in Panjab (India). Medicine (Balt.) 42: 229, 1963. CrossrefMedlineGoogle Scholar3. LARGENT EJ: Fluorosis. The Health Aspects of Fluorine Compounds, Ohio State University Press, Columbus, 1961. Google Scholar4. RICHENSINCK CJ: Effect of sodium fluoride on calcium metabolism of human beings. Nature (London) 191: 184, 1961. CrossrefMedlineGoogle Scholar5. RICHENSINCKIVANOVICH CJP: The effects of sodium fluoride on calcium metabolism of subjects with metabolic bone disease. J. Clin. Invest. 43: 545, 1964. CrossrefMedlineGoogle Scholar6. SCHRAERSCHRAERTROSTLED'ALFONSO HRHGA: The validity of measuring bone density from roentgenograms by means of a bone density computing apparatus. Arch. Biochem. 83: 486, 1959. CrossrefMedlineGoogle Scholar7. DOYLE FH: Ulnar bone mineral concentration in metabolic bone diseases. Brit. J. Radiol. 34: 698, 1961. CrossrefMedlineGoogle Scholar8. REIFENSTEINALBRIGHT ECF: The metabolic effects of steroid hormones in osteoporosis. J. Clin. Invest. 26: 24, 1947. CrossrefMedlineGoogle Scholar9. WHEDON GD: Effects of high calcium intakes on bones, blood and soft tissue; relationship of calcium intakes to balance in osteoporosis. Fed. Proc. 18: 1112, 1959. MedlineGoogle Scholar10. SCHWARTZCHOKASPANARIELLO EWVVA: Metabolic balance studies of high calcium intake in osteoporosis. Amer. J. Med. 36: 233, 1964. CrossrefMedlineGoogle Scholar11. LAFFERTYSPENCERPEARSON FWGEOH: Effects of androgens, estrogens and high calcium intakes on bone formation and resorption in osteoporosis. Amer. J. Med. 36: 514, 1964. CrossrefMedlineGoogle Scholar12. COHENGARDNER PFH: Induction of subacute skeletal fluorosis in a case of multiple myeloma. New Eng. J. Med. 271: 1129, 1964. CrossrefMedlineGoogle Scholar13. POSNEREANESHARPERZIPKIN ASEDRAI: X-ray diffraction analysis of the effect of fluoride on human bone apatite. Arch. Oral. Biol. 8: 549, 1963. CrossrefMedlineGoogle Scholar14. YATESDOTYTALMAGE CSRV: Effects of sodium fluoride on calcium homeostasis. Proc. Soc. Exp. Biol. Med. 115: 1103, 1964. CrossrefMedlineGoogle Scholar15. BELLDE V WEIR GHJB: Physical properties of bone in fluorosis, in Industrial fluorosis, a study of the hazard to man and animals near Fort William, Scotland. A report to the fluorosis committee. Memor. Med. Res. Coun. (Lond.) 22: 85, 1949. Google Scholar16. PURVES MJ: Some effects of administering sodium fluoride to patients with Paget's disease. Lancet 2: 1188, 1962. CrossrefMedlineGoogle Scholar17. BERNSTEINGURICOHENCOLLINSTAMVAKOPOULOS DSCPJJS: The use of sodium fluoride in metabolic bone disease. J. Clin. Invest. 42: 916, 1963. Google Scholar18. BLACKKLEINERBOLKER MMISH: The toxicity of sodium fluoride in man. New York J. Med. 49: 1187, 1949. MedlineGoogle Scholar19. GEALLBEILIN MGLJ: Sodium fluoride and optic neuritis. Brit. Med. J. 2: 355, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CLAYTON RICH, M.D.; PETER IVANOVICH, M.D.From the Department of Medicine, University of Washington School of Medicine, and the Radioisotope Service, Veterans Administration Hospital, Seattle, Wash.These studies were supported in part by grant AM-04701, the U. S. Public Health Service, Bethesda, Md. A portion of the work was conducted through the Clinical Research Center facility of the University of Washington, supported by grant FR-37, the National Institutes of Health, Bethesda, Md.Dr. Ivanovich is a Senior Fellow in Medicine, the University of Washington School of Medicine.Requests for reprints should be addressed to Clayton Rich, M.D., Veterans Administration Hospital, 4435 Beacon Avenue So. Seattle, Wash. 98108. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDevelopment and Evaluation of New Drugs for OsteoporosisFluoride Therapy of Established OsteoporosisUrinary fluoride excretion in responders and nonresponders after fluoride therapy in osteoporosisResponders and non-responders after fluoride therapy in osteoporosisGlucocorticoid-Induced OsteoporosisDOES FLUORIDATION OF DRINKING-WATER PREVENT BONE FRAGILITY AND OSTEOPOROSIS?Treatment of Osteoporosis with Sodium Fluoride and Calcium: Effects On Vertebral Fracture Incidence and Bone HistomorphometryFluoride Treatment of Osteoporosis: A New Look at an Old DrugDANIEL D. BIKLE, M.D., PH.D.OsteoporosisEffect of sodium fluoride, calcium carbonate, and vitamin D on the skeleton in multiple myelomaThe Effect of Drinking Water Fluoridation on the Fluoride Content, Strength and Mineral Density of Human BoneMultiple-Myeloma Bone DiseaseIncreased bone microhardness in fluoride treated ratsFluoride Therapy for Osteoporotic LesionsSystemic factors in alveolar bone lossBIBLIOGRAPHYEffect of combined therapy with sodium fluoride, vitamin D and calcium in osteoporosisEffects of fluoride on calcium metabolism in osteoporosisTHE BIOLOGIC BASIS OF RADIOLOGIC FINDINGS IN BONE DISEASEThe effects of fluoride and low calcium on the physical properties of the rat femurNutrition in SpaceReview of biochemistry of the calcified tissuesPROBLEMS AND PROGRESS IN GERIATRICS*Myeloma of bone treated with sodium fluoride59. Funktionelle Anpassung des Knochens auf physiologische und unphysiologische Beanspruchung Pathophysiologie und Behandlung der OsteoporoseEffect of Vitamin D and Fluoride on Experimental Bone Fracture Healing in RatsWater Fluoridation: Effect on bone fragility and skeletal calcium content in the rat 1 December 1965Volume 63, Issue 6Page: 1069-1074KeywordsBoneCalciumHospital medicineMedical servicesMorbidityOsteoporosisResearch facilitiesSodium ePublished: 1 December 2008 Issue Published: 1 December 1965 PDF downloadLoading ...