Is There Release of Mitochondrial Calcium in Toxic Injury?
Authors: John J. Lemasters, Anna-Liisa Nieminen, Brian Herman
Journal: Hepatology (1990)

HepatologyVolume 11, Issue 5 p. 902-903 CorrespondenceFree Access Is there release of mitochondrial calcium in toxic injury? John J. Lemasters M.D., PH.D., John J. Lemasters M.D., PH.D. Department of Cell Biology and Anatomy, Laboratories for Cell Biology, The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599–7090Search for more papers by this authorAnna-Liisa Nieminen M.S., Anna-Liisa Nieminen M.S. Department of Cell Biology and Anatomy, Laboratories for Cell Biology, The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599–7090Search for more papers by this authorBrian Herman PH.D, Brian Herman PH.D Department of Cell Biology and Anatomy, Laboratories for Cell Biology, The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599–7090Search for more papers by this author John J. Lemasters M.D., PH.D., John J. Lemasters M.D., PH.D. Department of Cell Biology and Anatomy, Laboratories for Cell Biology, The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599–7090Search for more papers by this authorAnna-Liisa Nieminen M.S., Anna-Liisa Nieminen M.S. Department of Cell Biology and Anatomy, Laboratories for Cell Biology, The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599–7090Search for more papers by this authorBrian Herman PH.D, Brian Herman PH.D Department of Cell Biology and Anatomy, Laboratories for Cell Biology, The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599–7090Search for more papers by this author First published: May 1990 https://doi.org/10.1002/hep.1840110538Citations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1 Thomas CE, Reed DJ. Current status of calcium in hepatocellular injury. Hepatology 1989; 10: 375– 384. 2 McCormick JG, Denton RM. Ca2+ as a second messenger within mitochondria. Trends Biochem Sci 1986; 11: 258– 262. 3 Hansford RG. Relation between cytosolic free Ca2+ concentration and the control of pyruvate dehydrogenase in isolated cardiac myocytes. Biochem J 1987; 241: 145– 151. 4 Moreno-Sanchez R, Hansford RG. Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration. Biochem J 1988; 256: 403– 412 5 Lemasters JJ, Nieminen A-L, Gores GJ, Wray BE, Herman B. Cytosolic free calcium and cell injury in hepatocytes. In: G Fiskum, ed. Cell calcium metabolism. New York: Plenum Press, 1989: 463– 470. 6 Nieminen A-L, Gores GJ, Dawson TL, Herman B, Lemasters JJ. Toxic injury from mercuric chloride in rat hepatocytes. J Biol Chem 1990; 265: 2399– 2408. 7 Lemasters JJ, DiGuiseppi J, Nieminen A-L, Herman B. Blebbing, free Ca+ + and mitochondrial membrane potential preceding cell death in hepatocytes. Nature 1987; 325: 78– 81. 8 Nieminen A-L, Gores GJ, Wray BE, Tanaka Y, Herman B, Lemasters JJ. Calcium dependence of bleb formation and cell death in hepatocytes. Cell Calcium 1988; 9: 237– 246. 9 Herman B, Nieminen A-L, Gores GJ, Lemasters JJ. Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability. FASEB J 1988; 2: 146– 151. 10 Lemasters JJ, Stemkowski CJ, Ji S, Thurman RG. Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated, perfused rat liver. J Cell Biol 1983; 97: 778– 786. 11 Gores GJ, Nieminen A-L, Fleishman KE, Dawson TL, Herman B, Lemasters JJ. Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes. Am J Physiol 1988 Sep; 255 (3 Pt 1): C315-;322. 12 Brodie AE, Reed DJ. Reversible oxidation of glyceraldehyde 3-phosphate dehydrogenase thiols in human lung carcinoma celis by hydrogen peroxide. Biochem Biophys Res Commun 1987; 148: 120– 125. 13 Webb JL. Enzyme and metabolic inhibitors. Vol 3. New York: Academic Press, 1966. 14 Gores GJ, Nieminen A-L, Wray BE, Herman B, Lemasters JJ. Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes: protection by intracellular acidosis against the onset of cell death. J Clin Invest 1989; 83: 386– 396. 15 Nieminen A-L, Gores GJ, Dawson TL, Herman B, Lemasters JJ. Protective effects of acidotic pH and fructose against lethal injury to rat hepatocytes by mitochondrial inhibitors, oxidative stress and ionophores. Toxicologist 1990; 10: 24. Citing Literature Volume11, Issue5May 1990Pages 902-903 ReferencesRelatedInformation