The Radiothyroxine Turnover Study in the Diagnosis of Thyroid Disease
Authors: GERALD BURKE
Journal: Annals of Internal Medicine (1966)

Article1 June 1966The Radiothyroxine Turnover Study in the Diagnosis of Thyroid DiseaseGERALD BURKE, M.D.GERALD BURKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1208 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe disappearance curve of plasma radioactivity after the intravenous injection of131I-labeled 1-thyroxine has been utilized experimentally to determine the magnitude and turnover of the exchangeable thyroid hormonal pool in man (1-4). This report is concerned with theclinicalapplication of the determination of radiothyroxine turnover to the characterization of thyroid function in patients with suspect thyroid disease in whom conventional (that is, routine) thyroid function studies had not allowed a definitive diagnosis. The results obtained demonstrate the value of a radiothyroxine turnover study in these circumstances and suggest that the rate of removal of circulating thyroxine is a significant...References1. HAMOLSKYFREEDBERGKURLANDWOLSKY MWASGSL: The exchangeable thyroid hormonal pool. I. Its magnitude and rate of turnover in various thyroid states in man. J. Clin. Invest. 32: 453, 1953. CrossrefMedlineGoogle Scholar2. BERSONYALOW SARS: Quantitative aspects of iodine metabolism. The exchangeable organic iodine pool and the rate of thyroidal secretion, peripheral degradation and fecal excretion of endogenously synthesized organically bound iodine. J. Clin. Invest. 33: 1533, 1954. CrossrefMedlineGoogle Scholar3. INGBARFREINKEL SHN: Simultaneous estimation of rates of thyroxine degradation and thyroid hormone synthesis. J. Clin. Invest. 34: 808, 1955. CrossrefMedlineGoogle Scholar4. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTriiodothyronine turnover studies in euthyroid patients with autonomous thyroid nodulesHematology, blood chemistry and protein polymorphisms in the white-tailed deer (Odocoileus virginianus)Occult Factitial Thyrotoxicosis Thyroxine Kinetics and Psychological Evaluation in Three CasesEDWARD ROSE, M.D., F.A.C.P., THEODORE P. SANDERS, M.D., WILLIAM L. WEBB JR., M.D., RALPH C. HINES, M.D.The triiodothyronine suppression test 1 June 1966Volume 64, Issue 6Page: 1208-1220KeywordsBiologicsEndocrinologyEstrogensHospital medicineIntravenous injectionsResearch laboratoriesThyroidThyroid diseasesThyroid hormonesThyroxine ePublished: 1 December 2008 Issue Published: 1 June 1966 PDF downloadLoading ...