tbuckley/cabot-search huggingface dataset:
Hypothyroidism and Primary Pulmonary Hypertension
Authors: David B. Badesch
Journal: Annals of Internal Medicine (1994)

Letters15 January 1994Hypothyroidism and Primary Pulmonary HypertensionDavid B. Badesch, MD, Norbert F. Voelkel, MD, and Bertron M. Groves, MDDavid B. Badesch, MDUniversity of Colorado Health Sciences Center; 420 East Ninth Avenue; Denver, CO 80262Search for more papers by this author, Norbert F. Voelkel, MDUniversity of Colorado Health Sciences Center; 420 East Ninth Avenue; Denver, CO 80262Search for more papers by this author, and Bertron M. Groves, MDUniversity of Colorado Health Sciences Center; 420 East Ninth Avenue; Denver, CO 80262Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-2-199401150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We were not aware of the report cited by Drs. Chin and Fisher. The journal in which that report was published is apparently not included in the Paperchase system, which we used for our MEDLINE search. Nevertheless, we are pleased to know of further evidence supporting the association between hypothyroidism and primary pulmonary hypertension, which now may be more commonly recognized. Additional information obtained since submission of our report also suggests that the association may not be uncommon. Of the 81 patients entered in a multicenter trial of the continuous infusion of prostacyclin in patients with severe primary ... Author, Article, and Disclosure InformationAffiliations: University of Colorado Health Sciences Center; 420 East Ninth Avenue; Denver, CO 80262 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1994Volume 120, Issue 2Page: 167-168KeywordsHyperthyroidismHypothyroidismPathogensProstacyclinPulmonary hypertension ePublished: 15 August 2000 Issue Published: 15 January 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy
Authors: Wei-Hong Chen, Wen-Cheng Lo, Wei-Che Hsu, Hong-Jian Wei, Hen-Yu Liu, Chian-Her Lee, Szu-Yu Tina Chen, Ying-Hua Shieh, David F. Williams, Win-Ping Deng
Journal: Biomaterials (2014)
CD4+ and CD8+ T Cells Bearing Naïve and Memory Markers In Blood Of Immigrants To Brooklyn Who Develop Asthma and Allergic Disease
Authors: Ashlei Mathew, Irina Katayeva, Seto Chice, Stephan Kohlhoff, Rauno O. Joks, Helen G. Durkin, Maria-Anna Vastardi
Journal: Journal of Allergy and Clinical Immunology (2014)
INCREASED BODY MASS INDEX IS ASSOCIATED WITH GREATER PREVALENCE, EXTENT AND SEVERITY OF CORONARY ARTERY DISEASE
Authors: Troy LaBounty, Millie Gomez, Allison M. Dunning, Fay Y. Lin, Augustin Delago, Benjamin J.W. Chow, Daniel Berman, Filippo Cadermartiri, Gil Raff, Hyuk-Jae Chang, Joerg Hausleiter, Leslee J. Shaw, Martin Hadamitzky, Matthew Budoff, Mouaz Al-Mallah, Philipp Kaufmann, Stephen Achenbach, Todd Villines, Tracy Callister, James K. Min
Journal: Journal of the American College of Cardiology (2011)
Anesthetists' Exposure to Radiation During Radium Implantation Procedures
Authors: Howard A. Trachtenberg
Journal: JAMA (1965)

IN ADDITION to the many diagnostic x-ray procedures carried out on anesthetized patients, the anesthetist is further exposed to ionizing radiation, particularly gamma rays, during radiation-therapy procedures. Despite the interest of both the general public and the medical profession in the hazards of radiation, there is relatively little mention of it in the anesthesia literature. Only four investigations measuring the exposure of anesthetists to ionizing radiation could be found, and these dealt only with diagnostic x-ray procedures.<sup>1-4</sup> We therefore investigated the amount of radiation to which the anesthetist is exposed during radium implantation for carcinomas of the uterine cervix and oral cavity. <h3>Method</h3> Radiation exposure was measured by means of indirect reading pocket chambers. Measurements were made in duplicate; the anesthetist wearing a pair of pocket chambers at chest level and another pair at waist level. The pocket chambers were charged immediately preceding each procedure and read immediately after
Satisfactory remission achieved by PUVA therapy in a case of crisis-type adult T-cell leukaemia/lymphoma with generalized cutaneous leukaemic cell infiltration
Authors: N. TAKEMORI, K. HIRAI, R. ONODERA, N. SAITO, K. YOKOTA, M. KINOUCHI, H. TAKAHASHI, H. IIZUKA
Journal: British Journal of Dermatology (1995)

Journal Article Satisfactory remission achieved by PUVA therapy in a case of crisis‐type adult T‐cell leukaemia/lymphoma with generalized cutaneous leukaemic cell infiltration Get access N. TAKEMORI, N. TAKEMORI Third Department of Internal Medicine, Asahikawa Medical College, 4‐5 Nishikagura, Asahikawa 078, Japan Search for other works by this author on: Oxford Academic Google Scholar K. HIRAI, K. HIRAI Third Department of Internal Medicine, Asahikawa Medical College, 4‐5 Nishikagura, Asahikawa 078, Japan Search for other works by this author on: Oxford Academic Google Scholar R. ONODERA, R. ONODERA Third Department of Internal Medicine, Asahikawa Medical College, 4‐5 Nishikagura, Asahikawa 078, Japan Search for other works by this author on: Oxford Academic Google Scholar N. SAITO, N. SAITO Third Department of Internal Medicine, Asahikawa Medical College, 4‐5 Nishikagura, Asahikawa 078, Japan Search for other works by this author on: Oxford Academic Google Scholar K. YOKOTA, K. YOKOTA Third Department of Internal Medicine, Asahikawa Medical College, 4‐5 Nishikagura, Asahikawa 078, Japan Search for other works by this author on: Oxford Academic Google Scholar M. KINOUCHI, M. KINOUCHI Department of Dermatology, Asahikawa Medical College, 4‐5 Nishikagura, Asahikawa 078, Japan Search for other works by this author on: Oxford Academic Google Scholar H. TAKAHASHI, H. TAKAHASHI Department of Dermatology, Asahikawa Medical College, 4‐5 Nishikagura, Asahikawa 078, Japan Search for other works by this author on: Oxford Academic Google Scholar H. IIZUKA H. IIZUKA Department of Dermatology, Asahikawa Medical College, 4‐5 Nishikagura, Asahikawa 078, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 6, 1 December 1995, Pages 955–960, https://doi.org/10.1111/j.1365-2133.1995.tb06933.x Published: 01 December 1995 Article history Accepted: 17 January 1995 Published: 01 December 1995
Ringworm Infection in a Cucumber Greenhouse
Authors: J. Alsop, A. P. Prior
Journal: BMJ (1961)

Of infections of skin and hair by dermatophytes those caused by some of the Microsporum species are apt to be encountered in epidemics.Cases of which M. gypseum is the cause are, however, much less frequent than those caused by M. canis or M. audouini.Warren (1956) recorded epidemics of over 1,000 cases with only two examples of infection due to M. gypseum.La Touche (1952) recorded M. canis as the predominant strain in Leeds.He related this finding to the animal reservoir.The report of the Medical Mycology Committee of the Medical Research Council (1956) does not mention M. gypseum as a prominent cause of ringworm and devotes attention to M. canis, which is known to have an animal habitat, and to M. audouini, which is known to spread essentially by human contact.M. gypseum has been repeatedly isolated from soil since Vanbreuseghem and Van Brussel (1952) took advantage of its keratinophilic properties to evolve a technique for the isolation of keratinophilic fungi from soil by baiting with hair.The present paper records, for the first time, an epidemic caused by M. gypseum in which the fungus was grown from soil which confirmed that infection was actually contracted from the soil itself.An epidemic was recorded by Whittle (1954) which was associated with work in a greenhouse, but the causative fungus was not isolated from the soil.
Oral Health in Patients With Type II Diabetes and Impaired Glucose Tolerance
Authors: Gail Cherry-Peppers, Jonathan A Ship
Journal: Diabetes Care (1993)

OBJECTIVE To assess the influence of type II diabetes and impaired glucose tolerance on dental, periodontal, and oral mucosal tissues. RESEARCH DESIGN AND METHODS We examined 11 subjects with type II diabetes, 32 with impaired glucose tolerance, and 43 control subjects from the oral physiology component of the Baltimore Longitudinal Study of Aging. At the time of the study, none of the participants was taking medication nor being treated for any medical problems other than diabetes. RESULTS Only a few statistically significant dental and periodontal changes were apparent in the group with type II diabetes, and no oral mucosal differences existed between the diabetes and control groups. Dental, periodontal, and oral mucosal parameters in patients with impaired glucose tolerance were essentially indistinguishable from the other two groups. CONCLUSIONS These findings suggest that among well-controlled individuals with type II diabetes and impaired glucose tolerance, few appreciable differences are evident in oral health.
Priapism complicating chronic granulocytic leukemia
Authors: R. Suri, J. M. Goldman, D. Catovsky, S. A. Johnson, Eve Wiltshaw, D. A. G. Galton
Journal: American Journal of Hematology (1980)

Abstract Since 1952 we have seen nine patients with priapism leading to a diagnosis of chronic granulocytic leukemia (CGL) and a tenth patient who gave a history of priapism when CGL was diagnosed as a result of other symptoms. Seven patients had had one or more transient episodes of prolonged erection before the diagnosis of CGL was established. All ten had high blood leukocyte counts (mean 380 × 10 9 /liter, range 186‐782) in comparison with other newly diagnosed patients. We estimate the incidence of this complication at 1%–2% of all male patients presenting with CGL. Treatment of patients in this series varied greatly. Five patients were treated mainly by local measures with or without cytotoxic drugs at conventional dosage, three were treated by sapheno‐cavernous bypass operations and leukapheresis followed by cytotoxic drugs at high dosage, and two were treated initially by leukapheresis alone. In general, the prompt initiation of measures designed to reduce the leukocyte count seemed more valuable than the surgical procedures employed in these patients.
Letter: The disc sensitivity test.
Authors: H Ericsson
Journal: BMJ (1974)

In this crossover study it was possible to achieve very satisfactory control of the blood pressure with few side effects during each treatment period in which a vasodilator (either prazosin or hydrallazine) was com- bined with a beta-adrenergic blocking agent and a thiazide.Blood pressure control had not been satisfactory before addition of the vasodilator capsules.All blood pressures were estimated with the London School of Hygiene and Tropical Medicine sphygmomanometer.-Weare, etc.,
Complete recovery from refractory immune thrombocytopenic purpura in three patients treated with etanercept
Authors: J.R. McMinn, Stephen Cohen, Joseph Moore, Scott Lilly, Joan Parkhurst, Michael D. Tarantino, Deirdra R. Terrell, James N. George
Journal: American Journal of Hematology (2003)

Abstract Management of patients with immune thrombocytopenic purpura (ITP) who have persistent, severe, and symptomatic thrombocytopenia following splenectomy is difficult and empirical. No single agent or regimen provides long‐term success for most patients, and for most treatments it is difficult to assess whether benefits outweigh risks. We report three consecutive patients with critical chronic refractory ITP, who responded promptly and completely following treatment with etanercept, an inhibitor of tumor necrosis factor‐alpha. These patients had failed 6–11 previous treatments. In the first patient, etanercept was given for its approved indication: a flare of co‐existing rheumatoid arthritis. The next two patients were treated with etanercept because of successful outcomes in the previous patients. Although etanercept appeared to be effective treatment for ITP in these 3 patients, the experimental nature of this treatment and the potential risks must be emphasized. On the basis of these case reports, a clinical trial has been initiated to systematically evaluate the efficacy and risks of etanercept in the management of children and adults with chronic ITP. Am. J. Hematol. 73:135–140, 2003. © 2003 Wiley‐Liss, Inc.
An Evaluation of Electrodiagnostic Testing
Authors: Arthur L. Watkins
Journal: New England Journal of Medicine (1958)

ELECTRODIAGNOSTIC tests are of interest whenever there is a question of lower-motor-neuron disease or injury. The fundamental electrophysiology of traditional testing has been understood for about a hundred years.1 Recent advances in electronics have made it possible, however, to record a wide variety of additional information particularly by electromyography.1 2 3 The purpose of this paper is to present a clinical evaluation of modern electrodiagnostic tests based on eighteen years' experience of nearly daily testing in several thousand cases rather than an exhaustive review of the literature. It is hoped that some illustrative case histories will help to clarify the subject for . . .
Abstract 4373: Targeting FGFR system in a model of HCC
Authors: Sven A. Lang, Tobias Scheller, Christian Moser, Maria Mycielska, Claus Hellerbrand, Hans J. Schlitt, Edward K. Geissler
Journal: Cancer Research (2012)

Abstract Activation of the fibroblast growth factor receptor (FGF/FGFR) system has been reported in a large number of human cancers including human hepatocellular carcinoma (HCC). Furthermore, expression of FGFR2 has been associated with aggressive tumor growth and poor prognosis in this tumor entity. Moreover, HCC is known to be a hypervascularized tumor and activation of the FGF/FGFR system is a crucial event in tumor angiogenesis. Hence, we addressed the issue of targeting the FGFR system in HCC (Huh-7, HepG2) and stromal cells (endothelial cells (EC), vascular smooth muscle cells (VSMC), hepatic stellate cells (HSC)). The FGFR inhibitor BGJ398 (Novartis Oncology, Basel, Switzerland) was used to inhibit FGFR activation. Effects of targeting FGFR on growth of cells were determined by MTT assays. Inhibition of constitutive and growth factor induced cell motility was investigated in modified Boyden Chamber assays. Activation of signaling pathways upon treatment with BGJ398 was assessed by Western Blot analyses whereas effects on mediators of tumor angiogenesis (VEGF-A, PDGF-B) where measured by RT-PCR and ELISA, respectively. Results show that inhibition of the FGF/FGFR system with BGJ398 led to dose-dependent inhibition of growth in tumor cells and ECs whereas only minor effects were observed on VSMC and HSCs. Moreover, motility of tumor and stromal cells (ECs, VSMCs, HSCs) was significantly impaired upon constitutive conditions (P&amp;lt;0.05 for all). In addition, FGFR inhibition led to decrease in HSC motility even when cell were incubated with conditioned media from cancer cells (P&amp;lt;0.05). With regards to activation of signaling intermediates, FGFR inhibition impaired constitutive and growth factor induced phosphorylation of Akt and ERK in HCC cell lines, ECs and HSCs whereas only minor effect was observed in VSMCs. Moreover, treatment with BGJ398 led to inhibition of c-Myc expression and significantly reduced VEGF-A production from cancer cells, as determined by Western blotting and ELISA, respectively. Evaluation of effectiveness of BGJ398 in animal models is currently ongoing. However, results so far indicate that targeting FGFR impairs angiogenic signaling and motility in HCC cell lines and stromal cells. Therefore, inhibition of FGFR warrants further evaluation and might be an interesting novel approach for anti-neoplastic treatment protocols in human HCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4373. doi:1538-7445.AM2012-4373
Early and Late Skeletal Effects of Radiation Therapy on ln-111 Labeled Leukocyte Imaging
Authors: CHRISTOPHER J. PALESTRO, PETER ROUMANAS, CHUN K. KIM, STANLEY J. GOLDSMITH
Journal: Clinical Nuclear Medicine (1992)

A 44-year-old woman with a history of cervical carcinoma underwent ln-111 labeled leukocyte imaging for evaluation of a fever of unknown origin. Although no discrete focus of infection was identified, regions of both increased and decreased skeletal marrow activity, corresponding to current and previous sites of radiotherapy, were observed.
Effect of Propranolol on Oxygen Binding to Hemoglobin <i>In Vitro</i> and <i>In Vivo</i>
Authors: MARSHALL A. LICHTMAN, JULES COHEN, MARION S. MURPHY, ELIZABETH A. KEARNEY, APRIL A. WHITBECK
Journal: Circulation (1974)

We have shown that propranolol reduces oxygen binding by hemoglobin in intact red cells by increasing the selective permeability of the red cell membrane resulting in an exodus of potassium, chloride, and water. The latter effects result in a new distribution of hydrogen ion between cell and plasma, and thereby a reduction in red cell pH. The reduction in pH can fully explain the change in hemoglobin's affinity for oxygen based on the Bohr effect. Either D- or DL-propranolol can produce the change in red cell pH and oxygen binding by hemoglobin. The drug action on permeability is not prevented by epinephrine, although it is by chlorbutanol. Hence, the membrane action of propranolol does not appear to be related to its activity as a beta-adrenergic receptor blocking agent. Propranolol produced a marked alteration in red cell shape as well as in hydration (hypovolumic stomatocytes). The two effects were separable since dehydration of the cell by the addition of sucrose to plasma did not result in stomatocytes and chlorbutanol blocked the enhancement of permeability of the red cell membrane by propranolol without preventing the shape change (isovolumic stomatocytes). This suggests that propranolol may have two separate sites of membrane interaction. Propranolol (10 to 360 mg) administered to human subjects did not affect hemoglobin-oxygen affinity. This is explained by the fact that the concentration in blood after such doses is nearly 4,000 to 100-fold lower than that required to achieve changes in blood in vitro.
Is BRAF a prognostic factor in stage III skin melanoma? A retrospective study of 72 patients after positive sentinel lymph node dissection
Authors: M. Picard, N. Pham Dang, M. D'Incan, S. Mansard, P. Dechelotte, B. Pereira, J.M. Mondie, I. Barthelemy
Journal: British Journal of Dermatology (2014)

Background BRAF was identified as an oncogene in skin melanoma in 2002, and since 2011 has been a therapeutic target in the treatment of metastatic melanoma. The role of BRAF mutation in tumour initiation and the disease course remains to be elucidated. Objectives The main objective of our study was to determine whether there is a relationship between BRAF status and overall survival in patients with a melanoma and a positive sentinel lymph node. We also sought an association between BRAF status and the clinicopathological features of the melanoma. Finally, we looked for a potential heterogeneity of BRAF status in primary and metastatic tumours. Methods All patients (n = 72) treated for melanoma and with a positive sentinel lymph node at the University Hospital of Clermont-Ferrand, France, between January 2000 and January 2010 were enrolled in the study. We investigated BRAF status in primary melanoma and lymph node metastatic tissue in our molecular pathology laboratory and collected the clinical and survival data. Results Of the 72 patients, 32 had at least one BRAF mutation. There was a statistically significant difference in overall survival between the BRAF-mutated and wild-type populations. The only clinical feature related to BRAF status was metastatic burden. Of the 25 patients in whom we obtained the status in both locations, five had a discordant result. Conclusions BRAF mutation is an indicator of poor prognosis in patients with stage III melanoma with a positive sentinel lymph node. BRAF status could be used in the staging of this population. BRAF has a role not only in cellular immortalization but also in metastatic spread.
Sex-Specific Prevalence of Adenomas and Colorectal Cancer
Authors: Michael Hoffmeister, Hermann Brenner
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unwanted Variations in the Rules of Practice
Authors: John E. Wennberg
Journal: JAMA (1991)

<i>Consensus</i>, as Webster reminds us, signifies "general agreement or unanimity; group solidarity in sentiment and belief."<sup>1</sup>The article by Kellie and Kelly in this issue ofThe Journal<sup>2</sup>confirms, once again, that there is little general agreement in medicine, and group solidarity about the standards of practice seems localized to geographic area and medical specialty. The authors demonstrate wide variations across the nation in the rules that professional review organizations (PROs) have adopted for evaluating whether physicians should be allowed to undertake a carotid endarterectomy, remove a cataract, or implant a pacemaker. The PRO guidelines often depart substantially from nationally developed practice guidelines. The work by Kellie and Kelly carries an important message. The strategies of micromanaged care have led to the development of a plethora of rules to govern clinical practice. Some, as in the case of the PRO, are at least accessible to analysis. Many others,
Welter of Words
Authors: Burgess L. Gordon
Journal: JAMA (1971)

Wild medical terminology, jumbled clauses, and lengthy sentences equal one dismayed reader. Thus, preciseness and clarity are treasured; nevertheless, complexity and pompousness prevail. The paradox of bizarre vocabulary and writings extends into academe, practice, and hospital administration. Curiously the language vagaries of business, notably from ecology and occupational health, are bleeding into the writings of medicine and, perhaps, vice versa. James Russell Lowell<sup>1</sup>lamented: ... the great vice of American writing and speaking is a studied want of simplicity.... few American writers or speakers wield their natural language with directness, force and precision.... while the school-master has been "starching" our language and smoothing it flat, the newspaper reporter has been stretching and swelling it to suit the occasion. An editorial in 1894<sup>1</sup>dwells thoughtfully on Lowell's ruminations. Short Anglo-Saxon words of common daily use are to be preferred whenever they express our meaning.... Technical words cannot be altogether avoided,