Digoxin Metabolism in Hypo- and Hyperthyroidism
Authors: JAMES E. DOHERTY
Journal: Annals of Internal Medicine (1966)

Article1 March 1966Digoxin Metabolism in Hypo- and HyperthyroidismStudies with Tritiated Digoxin in Thyroid DiseaseJAMES E. DOHERTY, M.D., F.A.C.P., WILLIAM H. PERKINS, M.D., F.A.C.P.JAMES E. DOHERTY, M.D., F.A.C.P., WILLIAM H. PERKINS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-489 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInterest in the action of digitalis in thyroid disease has been stimulated recently by the studies of Frye and Braunwald (1), which demonstrated that larger than the usual dose of acetyl strophanthadin was necessary to control the ventricular rate in hyperthyroid patients with atrial fibrillation. Smaller doses than usual would control the ventricular rate in patients with myxedema. These results are supported by many other clinical and experimental observations (2-6).We have published our findings of the serum levels, turnover rates, and excretion of digoxin in euthyroid patients after oral (7), intravenous (8), and intramuscular (9) administration of tritiated (radioactive...References1. FRYEBRAUNWALD RLE: Studies on digitalis. III. The influence of triiodothyronine on digitalis requirements. Circulation 23: 376, 1961. CrossrefMedlineGoogle Scholar2. MORROWGAFFNEYBRAUNWALD DHTEE: Studies on digitalis. VII. Influence of hyper- and hypothyroidism on the myocardial response to ouabain. J. Pharmacol. Exp. Ther. 140: 324, 1963. Google Scholar3. MCINTOSHMORRIS HDJJ: Problems in the use of digitalis in the management of congestive heart failure. Progr. Cardiov. Dis. 7: 360, 1965. CrossrefMedlineGoogle Scholar4. ROSENBERGGRAETTINGER MSJS: Digitalis intoxication—management and prevention. DM. November, 1962. Google Scholar5. INGBARFREINKEL SHN: Hypothyroidism. DM. September, 1958. Google Scholar6. RAWSON RW: Hyperthyroidism. DM. April, 1955. Google Scholar7. DOHERTYPERKINSMITCHELL JEWHGK: Tritiated digoxin studies in human subjects. Arch. Intern. Med. (Chicago) 108: 531, 1961. CrossrefMedlineGoogle Scholar8. DOHERTYPERKINS JEWH: Studies with tritiated digoxin in human subjects after intravenous administration. Amer. Heart J. 63: 528, 1962. CrossrefMedlineGoogle Scholar9. DOHERTYPERKINS JEWH: Studies following intramuscular tritiated digoxin in human subjects. Amer. J. Cardiol. 15: 170, 1965. CrossrefMedlineGoogle Scholar10. LUCHICONN RJHL: Digitalis action on cells: fable, fact, and fancy. Progr. Cardiov. Dis. 7: 336, 1965. CrossrefMedlineGoogle Scholar11. MARCUSKAPADIAKAPADIA FIGJGG: The metabolism of digoxin in normal subjects. J. Pharmacol. Exp. Ther. 145: 203, 1964. MedlineGoogle Scholar12. HARRISONBRANDENBURGONGLEYORVISOWEN CEROPAALCA: A compartmental analysis of single intravenously administered doses of tritiated digoxin in dogs. Ann. Intern. Med. 60: 709, 1964. LinkGoogle Scholar13. DOHERTYPERKINSWILSON JEWHMC: Studies with tritiated digoxin in renal failure. Amer. J. Med. 37: 536, 1964. CrossrefMedlineGoogle Scholar14. FOZZARDSMITH HAJR: Observations on the localization of tritiated digoxin in myocardial cells by radioautography and ultramicroscopy. Amer. Heart J. 69: 245, 1965. CrossrefMedlineGoogle Scholar15. LOWNAMARASINGHAMNEUMAN BRJ: New method for terminating cardiac arrhythmias. Use of synchronized capacitator discharge. JAMA 182: 548, 1962. MedlineGoogle Scholar16. DOHERTYPERKINS JEWH: Tissue concentration and turnover of tritiated digoxin in dogs. Amer. J. Cardiol. 17: 47, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES E. DOHERTY, M.D., F.A.C.P.; WILLIAM H. PERKINS, M.D., F.A.C.P.Affiliations: Little Rock, ArkansasFrom the Veterans Administration Hospital and Department of Medicine, University of Arkansas School of Medicine, Little Rock, Ark.This study was supported in part by grant HE06642-04 from the National Heart Institute and grant FR-49 from the Division of Research Facilities, National Institutes of Health, Bethesda, Md., and by a grant from Burroughs-Wellcome & Co. (U. S. A.), Inc., Tuckahoe, N. Y.This paper was presented in part at the 45th Annual Session of the American College of Physicians, April 9, 1964, at Atlantic City, N. J.Requests for reprints should be addressed to James E. Doherty, M.D., 300 E. Roosevelt Rd., Little Rock, Ark. 72206. 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DOHERTY, M.D.Pathophysiological Factors Influencing Drug KineticsMeasurement of Serum Digitalis Glycosides Clinical ImplicationsDigoxin: Immunologic Approaches to Measurement and Reversal of ToxicityTritiated DigoxinKinetik der Herzsteroide im Organismus des Menschen und der VersuchstiereSerum concentration and urinary excretion of3H-ouabain and3H-digitoxin in patients suffering from hyperthyroidism or hypothyroidismAssay of Digitalis Concentrations in BloodNewer Concepts Regarding Digitalis TherapyRESPIRATORY DEPRESSION IN THE COMA OF MYXEDEMA: TREATMENT WITH ETHAMIVAN INTRAVENOUSLY*Serumkonzentration und Ausscheidung von3H-Digitoxin beim Menschen unter normalen und pathologischen BedingungenMetabolism of digitalisSerum concentration and urinary excretion of 3H-Ouabain in patients suffering from liver or kidney diseasesPHARMACOKINETICS AS A BASIC MEDICAL PROBLEMRecognition of Digitalis Intoxication in the Presence of Atrial FibrillationJOHN A. KASTOR, M.D., PETER M. YURCHAK, M.D., F.A.C.P.The Distribution and Concentration of Tritiated Digoxin in Human TissuesJAMES E. DOHERTY, M.D., F.A.C.P., WILLIAM H. PERKINS, M.D., F.A.C.P., WILLIAM J. FLANIGAN, M.D. 1 March 1966Volume 64, Issue 3Page: 489-507KeywordsAtrial fibrillationExcretionHeartHospital medicineHyperthyroidismLongitudinal studiesResearch facilitiesThyroid diseases ePublished: 1 December 2008 Issue Published: 1 March 1966 Copyright & PermissionsCopyright ©, 1966, by The American College of PhysiciansPDF downloadLoading ...