tbuckley/cabot-search huggingface dataset:
Exercise after infarction.
Authors: J. Schouten, J. T. Schreuder
Journal: BMJ (1968)

MEDICALJOhave his treatment well under way before the doctor arrives.Again, you find it alarming to note that 39% of patients had been given seda- tives.As it has been standard teaching for years that there is a large psychological ele- ment in asthma is it surprising that a number of asthmatics are taking sedatives, regularly or intermittently, on the advice of doctors who are anxious to reduce the number of attacks of asthma ?" Alarm " in any case seems rather a strong word to use when the dose of phenobarbitone in one proprietary tablet used by many asthmatics is only 8 mg.(j gr.).The second of the two papers
Respiratory and Allergic Health Effects of Dampness, Mold, and Dampness-Related Agents: A Review of the Epidemiologic Evidence
Authors: Mark J. Mendell, Anna G. Mirer, Kerry Cheung, My Tong, Jeroen Douwes
Journal: Environmental Health Perspectives (2011)

ObjectivesMany studies have shown consistent associations between evident indoor dampness or mold and respiratory or allergic health effects, but causal links remain unclear. Findings on measured microbiologic factors have received little review. We conducted an updated, comprehensive review on these topics.Data sourcesWe reviewed eligible peer-reviewed epidemiologic studies or quantitative meta-analyses, up to late 2009, on dampness, mold, or other microbiologic agents and respiratory or allergic effects.Data extractionWe evaluated evidence for causation or association between qualitative/subjective assessments of dampness or mold (considered together) and specific health outcomes. We separately considered evidence for associations between specific quantitative measurements of microbiologic factors and each health outcome.Data synthesisEvidence from epidemiologic studies and meta-analyses showed indoor dampness or mold to be associated consistently with increased asthma development and exacerbation, current and ever diagnosis of asthma, dyspnea, wheeze, cough, respiratory infections, bronchitis, allergic rhinitis, eczema, and upper respiratory tract symptoms. Associations were found in allergic and nonallergic individuals. Evidence strongly suggested causation of asthma exacerbation in children. Suggestive evidence was available for only a few specific measured microbiologic factors and was in part equivocal, suggesting both adverse and protective associations with health.ConclusionsEvident dampness or mold had consistent positive associations with multiple allergic and respiratory effects. Measured microbiologic agents in dust had limited suggestive associations, including both positive and negative associations for some agents. Thus, prevention and remediation of indoor dampness and mold are likely to reduce health risks, but current evidence does not support measuring specific indoor microbiologic factors to guide health-protective actions.
Older Persons' Preferences for Site of Terminal Care
Authors: Terri R. Fried, Carol van Doorn, John R. O'Leary, Mary E. Tinetti, Margaret A. Drickamer
Journal: Annals of Internal Medicine (1999)

Background: Little is known about patients' preferences for site of terminal care. Objective: To describe older persons' preferences for home or hospital as the site of terminal care and to explore potential reasons for their preferences. Design: Cross-sectional quantitative and qualitative interviews. Setting: Participants' homes. Patients: Community-dwelling persons 65 years of age or older who were recently hospitalized with congestive heart failure, chronic obstructive pulmonary disease, or pneumonia and were not selected according to life expectancy; 246 patients participated in quantitative interviews and 29 participated in qualitative interviews. Measurements: Preference for site of terminal care and the reasons for that preference. Results: In quantitative interviews, 118 patients (48%) preferred terminal care in the hospital, 106 (43%) preferred home, and 22 (9%) did not know. One third changed their preference when asked about their preference in the event of a nonterminal illness. Reasons for preference identified during qualitative interviews included the desire to be with family members and concerns about burden to family members and their ability to provide necessary care. Concern about long-term care needs resulted in preference for a nursing home when choice was not constrained to home and hospital. Conclusions: Preference for home as the site of care for terminal illness exceeds existing practice. However, the current debate about home versus hospital as the ideal site for end-of-life care may ignore an important issue to older persons—namely, the care of disabilities that precede death.
Kantor and Margolis, reply to Dr Gilman
Authors: J. Kantor, D.J. Margolis
Journal: British Journal of Dermatology (2003)

Journal Article Kantor and Margolis, reply to Dr Gilman Get access J. Kantor, J. Kantor Dept. of Epidemiology and Biostatistics, Room 815 Blockley Hall 423 Guardian Drive Philadelphia, PA 19104, U.S.A. E‐mail: dmargoli@cceb.med.upenn.edu Search for other works by this author on: Oxford Academic Google Scholar D.J. Margolis D.J. Margolis Dept. of Epidemiology and Biostatistics, Room 815 Blockley Hall 423 Guardian Drive Philadelphia, PA 19104, U.S.A. E‐mail: dmargoli@cceb.med.upenn.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 4, 1 October 2003, Pages 897–898, https://doi.org/10.1046/j.1365-2133.2003.05576.x Published: 01 October 2003
A Proposal for the Cutoff Point of Waist Circumference for the Diagnosis of Metabolic Syndrome in the Japanese Population
Authors: Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Yutaka Imai
Journal: Diabetes Care (2006)

0.135% [95% CI 0.5-2.8] vs. 0.139% [1.2-1.57]).In Italy, we have "our own Finland," namely Sardinia.Italy has a peculiar epidemiology of type 1 diabetes.Sardinia has one of the highest incidences in the world ), while peninsular Italy has an overall incidence that is similar to other Mediterranean areas (8.4/100 [7.9 -8.9], 11.2/100 [10.3-12.2] in North Italy, and 6.2/100 [5.8 -6.7] in South Italy) (3).Only 2 of 1,373 patients aged Ͻ14 years from the Sardinian Registry of type 1 diabetes were diagnosed with autism spectrum disorders (0.1456% [0.13-0.16]), a finding similar to the Finnish data.On the contrary, a pattern similar to that observed by Freeman et al. (1) has been found in patients with type 1 diabetes aged Ͻ14 years from six Italian centers of pediatric diabetology equally distributed in the Italian Peninsula and in Sicily (0.72% [0.69 -0.75]).The diagnosis of autism spectrum disorder was confirmed in all cases using the DSM-IV (Diagnostic and Statistic Manual of Mental Disorders-IV).Autism spectrum disorder includes autism, Asperger disorder, pervasive developmental disorders (not otherwise specified), Rett's syndrome, and childhood disintegrative disorder.Its prevalence in the general Italian population is estimated at 0.1%.Our data seem to confirm the observation that the prevalence of autism in patients with type 1 diabetes is inversely associated to the incidence trends of diabetes in the observed areas.According to Daneman (4), if the relationship between autism and diabetes is based on shared genetic influences, this finding could be explained by the fact that, in areas with higher and rising incidence of type 1 diabetes without a parallel increase of the prevalence of autism,
An Atlas of Surgery of the Face, Mouth, and Neck
Authors: B. Eiseman
Journal: JAMA (1968)

The author of this new atlas is both a dentist and a surgeon who for many years has taught anatomy of the face to medical students at Columbia. His book reflects both for good and for bad this unique background. On the positive side, the atlas is particularly lucid in the diagrams, illustrations, and descriptive material that concern the bony framework of the head and neck. Indeed there are few such atlases used by general surgeons so helpful in the management of trauma to the jaws and face. The new atlas gives details of dental wiring which so often are neglected by general surgical texts or atlases. Helpful, too, are the diagrams explaining the mechanism of fractures about the face which seem so haphazard and random to the incognicente. The book will be helpful as a reference for students of anatomy. The book suffers from incomplete coverage concerning soft tissue
Drug Safety Monitoring—Reply
Authors: Brian L. Strom
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rethinking Adolescent Assent: A Triangular Approach
Authors: Amar D. Trivedi
Journal: The American Journal of Bioethics (2005)

Click to increase image sizeClick to decrease image size ACKNOWLEDGEMENTS I would like to thank Chalmers C. Clark and Kruti Trivedi for taking the time to read and provide critical comments and suggestions in preparation of this commentary. I would like to thank Professor Hans Halvorson, Dr. Dinker and Mrs. Varsha Trivedi, and my sister Arti, for all their support in my philosophical and bioethical endeavors. Most especially, I want to thank my sister Kruti for her enduring patience, insight, and intelligence in all she has taught me.
Lichen planus pemphigoides and multiple keratoacanthomas associated with colon adenocarcinoma
Authors: T. Hamada, W. Fujimoto, F. Okazaki, K. Asagoe, J. Arata, K. Iwatsuki
Journal: British Journal of Dermatology (2004)

Journal Article Lichen planus pemphigoides and multiple keratoacanthomas associated with colon adenocarcinoma Get access T. Hamada, T. Hamada Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Shikata‐cho 2‐5‐1, Okayama 700‐8558, Japan Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki, Okayama 701‐0192, Japan Search for other works by this author on: Oxford Academic Google Scholar W. Fujimoto, W. Fujimoto Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Shikata‐cho 2‐5‐1, Okayama 700‐8558, Japan Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki, Okayama 701‐0192, Japan Search for other works by this author on: Oxford Academic Google Scholar F. Okazaki, F. Okazaki Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Shikata‐cho 2‐5‐1, Okayama 700‐8558, Japan Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki, Okayama 701‐0192, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Asagoe, K. Asagoe Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Shikata‐cho 2‐5‐1, Okayama 700‐8558, Japan Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki, Okayama 701‐0192, Japan Search for other works by this author on: Oxford Academic Google Scholar J. Arata, J. Arata Department of Dermatology, Nakashima Hospital, Senoo 1878, Okayama 701‐0205, Japan E‐mail: toshihisa_hamada@yahoo.co.jp Search for other works by this author on: Oxford Academic Google Scholar K. Iwatsuki K. Iwatsuki Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Shikata‐cho 2‐5‐1, Okayama 700‐8558, Japan Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki, Okayama 701‐0192, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 1, 1 July 2004, Pages 252–254, https://doi.org/10.1111/j.1365-2133.2004.06074.x Published: 01 July 2004
To Have Been or Not to Have Been
Authors: Walter Cane
Journal: JAMA (1965)

<h3>To the Editor:—</h3> In lambasting "the use of incorrect (but correct-sounding) words," editorialist C.G.R. did just that by not wishing "to<i>hypothecate</i>that the latter fault was ever deliberate...." Dr. Gode of "Just Words" fame not so long ago devoted an entire passage trying to figure out what someone meant by "hypothecate." When Dr. Gode at the end was as far ahead as at the beginning, he threw in the towel in disgust and concluded, "I am certain he must have meant something!"
The European Cardiac Resynchronization Therapy Survey: comparison of outcomes between de novo cardiac resynchronization therapy implantations and upgrades
Authors: Nigussie Bogale, Klaus Witte, Silvia Priori, John Cleland, Angelo Auricchio, Fredrik Gadler, Anselm Gitt, Tobias Limbourg, Cecilia Linde, Kenneth Dickstein
Journal: European Journal of Heart Failure (2011)
Hyaluronic acid nanoparticles for active targeting atherosclerosis
Authors: Ga Young Lee, Jong-Ho Kim, Ki Young Choi, Hong Yeol Yoon, Kwangmeyung Kim, Ick Chan Kwon, Kuiwon Choi, Byung-Heon Lee, Jae Hyung Park, In-San Kim
Journal: Biomaterials (2015)
Possible Adverse Drug Reaction
Authors: Matilda S. McIntire
Journal: JAMA (1966)

<h3>To the Editor:—</h3> With more frequent reports of the effects of drugs on the fetus, it becomes imperative for the clinician to obtain a detailed drug history during the pregnancy when examining infants and children for developmental disorders, congenital malformations, mental retardation, cerebral palsy, and epilepsy. Excellent reviews have appeared by Cohlan,<sup>1</sup>Lucey,<sup>2</sup>Apgar,<sup>3</sup>and Sutherland and Light.<sup>4</sup>This brief note reports two microcephalic and mentally retarded children with motor dysfunction, from two separate pregnancies in the same mother, who took an appetite depressant drug during the first and second trimesters which contained methamphetamine hydrochloride and phenobarbital. The fourth pregnancy in the same mother during which no drugs were taken produced a normal child. While this cannot be considered conclusive evidence, the possibility of a drug effect exists. Powell and Johnstone reported a mother who took phenmetrazine hydrochloride (Preludin) during the first trimester of the first
Treatment of Malignant Tertian Malaria
Authors: G. Covell
Journal: BMJ (1949)

deficiencies are rather rare.It has been suggested that these vitamin deficiencies constitute a primary aetiological factor in the sprue syndrome (Verzar and McDougall, 1936; Castle, Rhoads, Lawson, and Payne, 1935).There is no satisfactory evidence of a direct relation between these vitamins and the fat-absorption mechanism (Frazer, 1947b).The signs of these deficiencies can be dramatically relieved without any effect on the fat-absorption defect (Cooke et al., 1946).Classical cases of deficiency of these vitamins may occur with normal fat absorption.These deficiencies, which come and go during the course of the sprue syndrome, are probably secondary changes attributable to successful competition with the host for common essential nutrients on the part of intestinal bacteria. ConclusionsIt is concluded that the underlying fat-absorption fault is a defect in particulate absorption.The consequent absorption and excretion of fatty acids account for most of the major features of the sprue syndrome.Certain intermittent characteristics may be attributed to high growth of intestinal bacteria.The primary cause of faulty particulate absorption probably varies in different cases- many cases of tropical sprue may be primarily due to dietary faults, whereas some underlying defect, possibly an enzyme deficiency, may be a major factor in most cases of non-tropical sprue and the coeliac syndrome.Intestinal flora changes occur secondarily in most cases of sprue, but they may have a more important aetiological role in some cases of gastro-colic fistula.The final picture of the aetio- logy of the sprue syndrome will be achieved only as a result of further detailed study of the fat-absorption defec,- and experimental investigations designed to differentiate primary and secondary changes.
Reversible dementia. Illustrative cases, definition, and review
Authors: J. Cummings
Journal: JAMA (1980)

The pitfalls of overlooking correctable causes of progressive intellectual deterioration are illustrated by five patients whose conditions were originally diagnosed as primary dementia. In each case careful evaluation disclosed a reversible process. Treatable intracranial conditions, systemic illnesses, endocrinopathies, deficiency states, collagen-vascular disorders, heavy-metal intoxications, exposure to industrial agents, infections, and the effects of drugs must all be considered in the evaluation of the patient with dementia. Such conditions are less likely to go undiagnosed when dementia is regarded as a nonspecific syndrome of progressive intellectual compromise rather than a specific diagnosis. (<i>JAMA</i>243:2434-2439, 1980)
Mebutamate as Antihypertensive Agent in Hospital Outpatients
Authors: A. C. Corcoran
Journal: JAMA (1962)

Mebutamate (Capla) (300 mg.) was a depressor in hypertension in single patient tests in which meprobamate (400 mg.) was not. In 30 outpatients mebutamate alone (600-1,200 mg. per day) was effective in most with mild or moderate diastolic hypertension and, with thiazides, e.g., hydrochlorothiazide, in most with moderately severe and even severe hypertensive disease, including some with arteriosclerotic mixed hypertension. A subsequent blind study of 10 patients verified this impression. Alone, or in combination, mebutamate is usefully antihypertensive in what seems to be a majority of office patients with hypertension; some patients report a disturbing, usually transient, drowsiness when given full doses (300-mg. four times a day); initial dosage may be desirably 150 mg. three times a day and 300 mg. at bedtime. No serious side effects characteristic of Rauwolfia drugs and ascribable to mebutamate were observed during nearly 1 year in 34 patients. Mebutamate is ineffective in malignant hypertension.
Acute Atypical Coronary Artery Insufficiency
Authors: DAVID LITTMANN, J. H. BARR
Journal: Circulation (1952)

Not all patients with acute coronary thrombosis or inadequacy develop classic myocardial infarction. Almost 30 per cent of such patients were found to have atypical and apparently less extensive myocardial injury as estimated by the clinical and electrocardiographic findings. The morbidity as well as the mortality was of a lesser order and a somewhat different therapeutic regimen could be employed.
Reproductive assessment by continuous breeding: evolving study design and summaries of ninety studies.
Authors: R E Chapin, R A Sloane
Journal: Environmental Health Perspectives (1997)

The Reproductive Assessment by Continuous Breeding (RACB) design has been used by the National Toxicology Program for approximately 15 years. This article details the evolutions in the thinking behind the design and the end points used in the identification of hazards to reproduction. Means of nominating chemicals are provided, and both early and current designs are described as well as some proposed changes for the future. This introduction is followed by a text and tabular summary of each study performed to date. We hope that this will not only be an explicit presentation of the findings of this testing program to date, but will help stimulate thinking about new ways to detect and measure reproductive toxicity in rodents, and help identify new relationships among the end points that are measured in such studies.
Randomised comparison of cost effectiveness of guided self management and traditional treatment of asthma in Finland
Authors: A. Lahdensuo, T. Haahtela, J. Herrala, T. Kava, K. Kiviranta, P. Kuusisto, M. Pekurinen, E. Peramaki, S. Saarelainen, T. Svahn, B. Liljas
Journal: BMJ (1998)

In many countries the cost of caring for patients with asthma is high.1 Guidelines have recommended guided self management for the treatment of asthma. 2 3 We recently compared the efficacy of guided self management with traditional treatment for asthma4 and here report the cost effectiveness of the two treatments.

One hundred and fifteen patients with mild to moderately severe asthma were randomly allocated guided self management or traditional treatment. The 56 patients allocated guided self management were given personal education and they were taught to measure their peak expiratory flow rate every morning for a year. If the value fell below 85% of their predetermined optimal value on any morning they were instructed to double their dose of inhaled corticosteroid for 2 weeks. If the value fell below 70% of the optimal value on any morning they were to take oral prednisolone (40 mg/day) for 7 days and immediately contact their nurse or doctor. The 59 patients allocated traditional …
Obesity Is Mediated by Differential Aryl Hydrocarbon Receptor Signaling in Mice Fed a Western Diet
Authors: Joanna S. Kerley-Hamilton, Heidi W. Trask, Christian J.A. Ridley, Eric DuFour, Carol S. Ringelberg, Nilufer Nurinova, Diandra Wong, Karen L. Moodie, Samantha L. Shipman, Jason H. Moore, Murray Korc, Nicholas W. Shworak, Craig R. Tomlinson
Journal: Environmental Health Perspectives (2012)

Background: Obesity is a growing worldwide problem with genetic and environmental causes, and it is an underlying basis for many diseases. Studies have shown that the toxicant-activated aryl hydrocarbon receptor (AHR) may disrupt fat metabolism and contribute to obesity. The AHR is a nuclear receptor/transcription factor that is best known for responding to environmental toxicant exposures to induce a battery of xenobiotic-metabolizing genes.Objectives: The intent of the work reported here was to test more directly the role of the AHR in obesity and fat metabolism in lieu of exogenous toxicants.Methods: We used two congenic mouse models that differ at the Ahr gene and encode AHRs with a 10-fold difference in signaling activity. The two mouse strains were fed either a low-fat (regular) diet or a high-fat (Western) diet.Results: The Western diet differentially affected body size, body fat:body mass ratios, liver size and liver metabolism, and liver mRNA and miRNA profiles. The regular diet had no significant differential effects.Conclusions: The results suggest that the AHR plays a large and broad role in obesity and associated complications, and importantly, may provide a simple and effective therapeutic strategy to combat obesity, heart disease, and other obesity-associated illnesses.
The Dip-slide in Urology
Authors: F. R. Jackaman, J. H. Darrell, R. Shackman
Journal: BMJ (1973)

To assess the value of the Uricult dip-slide in a hospital urological unit, bacteriological examination of 1,033 urine specimens was compared by this technique and by conventional methods. In 87% of cases identical results were obtained using the dip-slides and the standard laboratory culture plates. Insignificant differences occurred in 10%, and a serious discrepancy between the two methods was found in only 3%. The Uricult dip-slide technique is valuable as a bacteriological screening procedure in urological practice but subculturing from the slide is not recommended except in special circumstances.