Acute Necrotizing Eosinophilic Myocarditis as a Manifestation of Severe Hypersensitivity Myocarditis
Authors: Mark A. Getz, Ramiah Subramanian, Tim Logemann, Ford Ballantyne
Journal: Annals of Internal Medicine (1991)

Brief Report1 August 1991Acute Necrotizing Eosinophilic Myocarditis as a Manifestation of Severe Hypersensitivity MyocarditisAntemortem Diagnosis and Successful TreatmentMark A. Getz, MD, Ramiah Subramanian, MD, Tim Logemann, MD, Ford Ballantyne, MDMark A. Getz, MD, Ramiah Subramanian, MD, Tim Logemann, MD, Ford Ballantyne, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-3-201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute necrotizing eosinophilic myocarditis is characterized by acute and fulminant congestive heart failure that has previously been uniformly fatal (1, 2). Predisposing factors include an initial viral infection and an underlying allergic diathesis. This disease's pathologic characteristics include eosinophilic and lymphocytic infiltration with extensive myocardial cell necrosis and no notable extracardiac pathologic findings. Hypersensitivity myocarditis is characterized by rash, fever, sinus tachycardia, and eosinophilia related to a drug allergy. This entity is also characterized by eosinophilic and lymphocytic infiltration of the myocardium, but necrosis is uncommon (3). Patients with hypersensitivity myocarditis usually are not critically ill, and they respond to...References1. Herzog C, Snover D, and Staley N. Acute necrotizing eosinophilic myocarditis. Br Heart J. 1984;52:343-8. CrossrefMedlineGoogle Scholar2. deMello D, Liapis H, Jureidini S, Nouri S, Kephart G, and Gleich G. Cardiac localization of eosinophil-granule major basic protein in acute necrotizing myocarditis. N Engl J Med. 1990;323:1542-5. CrossrefMedlineGoogle Scholar3. Fenoglio J, McAllister H, and Mullick F. Drug related myocarditis. Hum Pathol. 1981;12:900-7. CrossrefMedlineGoogle Scholar4. Doherty N and Siegel R. Cardiovascular manifestations of systemic lupus erythematosus. Am Heart J. 1984;110:1257-65. CrossrefGoogle Scholar5. Billingham M. Pharmacotoxic myocardial disease: an endomyocardial study. Heart Vessels (Suppl). 1985;1:278-82. CrossrefGoogle Scholar6. French A and Weller C. Interstitial myocarditis following the clinical and experimental use of sulfonamide drugs. Am J Pathol. 1942;18:109-21. MedlineGoogle Scholar7. Morrow P, Hardin N, and Bonadies J. Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine. J Forensic Sci. 1989;34:1016-20. CrossrefMedlineGoogle Scholar8. Taliercio C, Olney B, and Lie J. Myocarditis related to drug hypersensitivity. Mayo Clin Proc. 1985;60:463-8. CrossrefMedlineGoogle Scholar9. Parrillo J. Heart disease and the eosinophil [Editorial]. N Engl J Med. 1990;323:1560-1. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Mark A. Getz, MD; Ramiah Subramanian, MD; Tim Logemann, MD; Ford Ballantyne, MDFrom the University of Wisconsin Medical School and the William S. Middleton Memorial Veterans Affairs Hospital, Madison, Wisconsin. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCardiomegaly and Low Voltage Suggest Cardiac Involvement in a Patient With Hypereosinophilic Syndrome: A Case ReportEosinophilic Myocarditis: When Allergies Attack the Heart!Cardiovascular Side Effects of Psychotropic AgentsDiagnosis and treatment of eosinophilic myocarditisThe spectrum of myocarditis: from pathology to the clinicsSudden unexpected death in a case of necrotizing eosinophilic myocarditisHirninfarkt als Erstsymptom einer eosinophilen MyokarditisDramatic and early response to low-dose steroid in the treatment of acute eosinophilic myocarditis: a case reportAcute fulminant necrotizing eosinophilic myocarditis: early diagnosis and treatmentEosinophilic MyocarditisEosinophilic myocarditis during treatment with olanzapine - report of two possible casesDrug Reaction, Eosinophilia, and Systemic Symptoms (DRESS) syndrome associated with allopurinol leading to acute necrotizing eosinophilic myocarditis and death due to papillary muscle ruptureA case of idiopathic giant cell myocarditis with a past history of sarcoidosisFatal Acute Necrotizing Eosinophilic Myocarditis Temporally Related to Use of Adalimumab in a Patient With Relapsing PolychondritisGiant cell myocarditis associated with amoxicillin hypersensitivity reactionThe role of focal myocardial inflammation in sudden unexpected cardiac and noncardiac deaths—A clinicopathological studyA review of DRESS-associated myocarditisDiagnostic Biopsies of the Native HeartCardiovascular Magnetic Resonance Imaging in MyocarditisFulminant myocarditis as a late sequela of DRESS: Two casesMyocarditis at Post-Mortem Examination: A Forensic PerspectiveSection 16: Myocarditis: Current TreatmentA case of acute necrotising eosinophilic myocarditis with an associated raised myoplasma serology an incidental finding or a causal association?Case 36-2007MyocarditisFatal Cephalosporin-Induced Acute Hypersensitivity MyocarditisCœur et congélateur : à propos d'un cas d'hyperéosinophilie et de spasme coronaireSection 16: Myocarditis: Current TreatmentDiagnosis of MyocarditisA Case of Acute Eosinophilic Myopericarditis Presenting with Cardiogenic Shock and Normal Peripheral Eosinophil CountEosinophilic MyocarditisBiventricular assist device placement and immunosuppression as therapy for necrotizing eosinophilic myocarditisCardiogenic shock and peripheral eosinophilia in a young womanDiagnostic approach to the patient with cardiomyopathy: Whom to biopsyTherapeutic Role of Pericardiocentesis for Acute Necrotizing Eosinophilic Myocarditis With Cardiac TamponadeEosinophilic Heart: Marked Left Ventricular Wall Thickening and Myocardial Dysfunction Improving With Corticosteroid TherapyUsefulness of eosinophilic cationic protein as a marker of eosinophilic myocarditis in a childThe Etiologic Basis of Congestive Heart FailureIdiopathic Eosinophilic Endomyocarditis in the Absence of Peripheral EosinophiliaHypersensitivity myocarditis presenting as cardiogenic shockMyocarditis Related to Clozapine TreatmentAcute Necrotizing Eosinophilic Myocarditis Successfully Treated by High Dose Methylprednisolone.Giant Cell Myocarditis as a Manifestation of Drug HypersensitivityPathologie des EndokardEosinophilia in a 23-year-old woman with asthmaHypersensitivity myocarditis caused by an allergic reaction to cefaclorEosinophilic Myocarditis Manifesting as Myocardial Infarction: Early Diagnosis and Successful TreatmentEosinophilic Myocarditis Manifesting as Myocardial Infarction: Early Diagnosis and Successful Treatment 1 August 1991Volume 115, Issue 3Page: 201-202KeywordsArmed forcesHealth services researchHeart failureHypersensitivityMuscular dystrophiesMyocarditisMyocardiumNecrosisRashesTachycardia ePublished: 1 December 2008 Issue Published: 1 August 1991 PDF downloadLoading ...