tbuckley/cabot-search huggingface dataset:
724. Herpes Simplex Virus 1 Amplicon Vector-Mediated siRNA Targeting Epidermal Growth Factor Receptor Inhibits Growth of Human Glioma Cells in Culture and In Vivo
Authors: Okay Saydam, Daniel Glauser, Irma Heid, Gulen Turkeri, Andreas Jacobs, Mathias Ackermann, Cornel Fraefel
Journal: Molecular Therapy (2005)
So Goes It in America
Authors: Jeffrey R. M. Kunz
Journal: JAMA (1979)

In recent months, readers ofThe Journalhave been exposed to thought-provoking communications on the problems of rules and regulations. Two articles come immediately to mind and deserve succinct recapitulation. In a brief COMMENTARY, Aring<sup>1</sup>argues that rules restrain positive spontaneity and creativity while encouraging an adversarial social system. In a later SPECIAL COMMUNICATION, Landau<sup>2</sup>interprets the restrictive effects of the Food and Drug Administration's labeling regulations on estrogenic agents. Both pieces are worth rereading, for they outline some of the conceptual and actual hazards of relying on the "weak reed" of regulations. Rules and regulations do exist, however, and we cannot write them off as easily as they are being written into our<i>Federal Register</i>. They are being increasingly instituted, at least in part, because members of our society no longer exercise self-discipline; because the striving for the individual is taking precedence over the greater good; and
Intraoperative ultrasound in detecting hepatic metastases
Authors: Kenneth J. W. Taylor
Journal: Hepatology (1988)

As a new screening procedure, intraoperative ultrasonography using high-resolution real-time instruments was used routinely in 84 colorectal cancer operations to scan the entire liver for liver metastases. In 10 operations (11.9%), intraoperative ultrasonography identified 14 previously unrecognized metastatic tumors, all of which were less than 2 cm in size and were nonpalpable. The sensitivity of this technique in detecting metastatic liver lesions (97.8%) was significantly superior (p < 0.01) to that of preoperative ultrasound (41.3%), computed tomography (47.8%), and surgical exploration (58.7%), while the specificity of each test was comparable (approximately 90%). High-resolution intraoperative ultrasonography is safe, simple to perform and more accurate than preoperative imaging and surgical exploratory methods. Therefore its use is encouraged during colorectal cancer surgery for screening of liver metastases.
Prolonged fecal excretion of hepatitis A virus in adult patients with hepatitis A as determined by polymerase chain reaction
Authors: H Yotsuyanagi
Journal: Hepatology (1996)

In hepatitis A virus (HAV) infection, fecal excretion of the virus has been reported to cease shortly after symptoms occur. Although there have been several reports on detection of HAV in feces using polymerase chain reaction (PCR), the duration of fecal HAV shedding in human adult hepatitis A has not been well described. In the present study, we applied the reverse-transcription (RT)-PCR system to the detection of fecal HAV RNA in 10 patients with sporadic hepatitis A. The viral genomic RNA was detected in the stools from five patients after the onset of clinical symptoms. All stool samples collected within 10 days of onset of illness were HAV-RNA-positive, and the duration of positivity lasted from a few days to as long as 3 months. In four patients, HAV RNA was detected in the stool even after the serum alanine transaminase (ALT) levels had peaked, and in one patient well after ALT levels fell to normal. These results show that fecal shedding of HAV can last for months after resolution of symptoms and such patients could be a source of further spreading of the virus in the community.
Advocates' Perspective: Neoadjuvant Chemotherapy for Breast Cancer
Authors: Jane Perlmutter, Susan Axler, Carole Baas, Barbara J. Beckwith, Amy Bonoff, Susan Brain, Maryellen Delapine, Margaret Devine, Elizabeth Frank, Valerie Fraser, Marjorie Gallece, Cindy Geoghegan, Hiam Hamade, Diane Heditsian, Bonnie Hirschhorn, Stephen Kandell, Deborah Laxague, Barbara LeStage, Maria Lyzen, Debra Madden, Shirley A. Mertz, Beverly J. Parker, Nancy Roach, Nancy Sauers, Linda Vincent, Dorothy Waddell, Maria Wetzel, Kimberly Wright
Journal: Journal of Clinical Oncology (2012)
The Management of High-Grade Hilar Strictures by Endoscopic Insertion of Self-Expanding Metal Endoprostheses
Authors: R. A. Peters, S. G. J. Williams, M. Lombard, J. Karani, D. Westaby
Journal: Endoscopy (1997)

Treatment options for unresectable hepatic hilar strictures include percutaneous or endoscopic stent insertion, using either standard Teflon or self-expanding metal endoprostheses. The use of Teflon stents is complicated by stent migration and high occlusion rates. Published series of endoscopically placed metal stents have not concentrated on their use in the treatment of high-grade hilar strictures (Bismuth grades II and III). We therefore undertook a prospective and open pilot study to evaluate the efficacy of endoscopically placed metal endoprostheses in the palliation of jaundice due to high-grade hilar strictures.Self-expanding metal stents were placed endoscopically in 17 patients (nine women, eight men; median age 64 years, range 33-77). Of the 17 malignancies 11 patients (65%) had a diagnosis of cholangiocarcinoma, and 12 (71%) had Bismuth grade III strictures.The stents were inserted successfully in all 1 patients. Adequate drainage, as demonstrated by a significant reduction in bilirubin, was achieved in 1: (88%); the two patients in whom drainage failed had extensive intrahepatic disease. Early complications (cholangitis) developed in one patients (6%), and there were seven late complications (41%) in five patients (four occluded stents and three cases of duodenal compression). The stent patency appeared to be prolonged (median stent patency 12 months, range 1.5-24 months, in patients surviving five months or more). The median survival was ten months (range 1-48 months) after stent insertion. All of the patients died during follow-up.These results suggest that endoscopically placed metal stents offer effective palliation for high grade hilar malignancies, although controlled trial comparing the use of metal and Teflon endoprostheses in this patient group are required.
Hot foot syndrome.
Authors: I C Paterson
Journal: BMJ (1978)

cortical thinning being the only radiological sign of osteomalacia.Thus true osteoporosis was responsible for the cortical thinning in only the cases of steroid therapy and Cushing's syndrome-three out of 18 cases.The other 15 were due to hyperparathyroidism and osteomalacia.Cortical thinning cannot therefore be regarded as synonymous with osteoporosis.
Response to Open Peer Commentaries on “Research 2.0: Social Networking and Direct-to-Consumer Personal Genomics”
Authors: Sandra Soo-Jin Lee, LaVera Crawley
Journal: The American Journal of Bioethics (2009)

Click to increase image sizeClick to decrease image size Acknowledgment S. S. Lee acknowledges support from NIH/NHGRI P50 #HG003389 and L. C. acknowledges support from the Stanford School of Medicine Child Health Research Program for their research on social networking.
The Kaspar Hauser Syndrome of 'Psychosocial Dwarfism': Deficient Statural, Intellectual, and Social Growth Induced by Child Abuse
Authors: Jay T. Shurley
Journal: JAMA (1994)

Kaspar Hauser emerged at the Haller Gate in the city of Nuremberg, Bavaria, on May 26,1828, shrouded in mystery and greatly romanticized. A 17-year-old dwarfed male, with a blank mind and without language, he exhibited a spurt of growth and intellectual and social development, becoming a highly peculiar and limited young man whose origin remained enigmatic when he was assassinated on December 14,1833. His story became the sensation of the day throughout Europe and has been enshrined in literature through the present. In his book, John Money proposes "Kaspar Hauser syndrome" to designate a previously poorly understood and described constellation of symptoms and findings he and others have noted in small children who had been sequestered in their homes and subjected by their caretakers to extreme neglect and other abuses, lasting to adolescence in some cases. His appears to be the first book-length treatment in the scientific literature of this
Trends in patch-test results and allergen changes in the standard series: A Mayo Clinic 5-year retrospective review (January 1, 2006, to December 31, 2010)
Authors: Ashley B Wentworth, James A Yiannias, James H Keeling, Matthew R Hall, Michael J Camilleri, Lisa A Drage, Rochelle R Torgerson, Debra D Fett, Amy V Prakash, Leigh Ann Scalf, Eve M Allen, Janis S Johnson, Nidhi Singh, Diane L Nordberg Linehan, Jill M Killian, Mark D P Davis
Journal: Journal of the American Academy of Dermatology (2013)
Multimodality Imaging Evaluation of Functional and Clinical Benefits of Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion Lesion
Authors: Dongdong Sun, Jing Wang, Yue Tian, Kazim Narsinh, Haichang Wang, Chengxiang Li, Xiaowei Ma, Yabing Wang, Dongjuan Wang, Chunhong Li, Joseph C Wu, Jie Tian, Feng Cao
Journal: Theranostics (2012)

To determine the effects of percutaneous coronary intervention (PCI) on cardiac perfusion, cardiac function, and quality of life in patients with chronic total occlusion (CTO) lesion in left anterior descending (LAD) coronary artery.Patients (n=99) with CTO lesion in the LAD coronary artery who had successfully undergone PCI were divided into three groups based on the SPECT/CTCA fusion imaging: (a) no severe cardiac perfusion defects (n=9); (b) reversible cardiac perfusion defects (n=40); or (c) fixed cardiac perfusion defects (n=50). No statistical difference of perfusion abnormality was observed at 6 months and 1 year after PCI in group (a). In group (b), SPECT/CTCA fusion imaging demonstrated that cardiac perfusion abnormality was significantly decreased 6 month and 1 year after PCI. Left ventricular ejection fraction (LVEF) increased significantly at 6 months and 1 year follow up. Quality of life improved at 6 months and 1 year after PCI procedure. Moreover, patients in group (c) also benefited from PCI therapy: a decrease in cardiac perfusion abnormality, an increase in LVEF, and an improvement in quality of life. PCI of coronary arteries in addition to LAD did not significantly affect cardiac function and quality of life improvement in each group.PCI exerts functional and clinical benefits in patients with CTO lesion in LAD coronary artery, particularly in patients with reversible cardiac perfusion defects. SPECT/CTCA fusion imaging may serve as a useful tool to evaluate the outcomes of patients with CTO lesion in LAD coronary artery.
Decreased myocardial contractility after damage to endocardial endothelium is caused mainly by loss of endothelin production
Authors: A. M. Shah
Journal: Cardiovascular Research (1995)

Journal Article Decreased myocardial contractility after damage to endocardial endothelium is caused mainly by loss of endothelin production Get access Ajay M. Shah Ajay M. Shah Department of Cardiology, Cardiovascular Sciences Research Group, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 30, Issue 5, November 1995, Pages 644–645, https://doi.org/10.1016/S0008-6363(95)00203-0 Published: 01 November 1995
Activation-Repolarization Coupling in the Normal Swine Endocardium
Authors: Lior Gepstein, Gal Hayam, Shlomo A. Ben-Haim
Journal: Circulation (1997)

Background While abnormalities of activation and repolarization play an important role in arrhythmogenesis, little information is available on the interaction between their spatial dispersions in the heart. This study examined the effects of activation spread on the spatial distribution of the repolarization properties during different depolarization patterns. Methods and Results Left ventricular (LV) endocardial activation and repolarization patterns were mapped in 13 healthy pigs. LV local activation, repolarization, and activation-recovery interval (ARI) times were determined from the intracardiac unipolar electrograms, color-coded, and superimposed on a three-dimensional anatomic map of the ventricle generated with a nonfluoroscopic mapping system. ARI values correlated with the duration of monophasic activation potential recorded from onset of activation to time of 90% repolarization ( r =.97, P &lt;.01). Activation time range of the left ventricle was 42±5 ms (mean±SEM) during sinus rhythm and 54±5 ms during right ventricular septal pacing. ARI inversely correlated with the corresponding activation times during both sinus ( r 2 =.76±.03) and paced ( r 2 =.77±.02) rhythms. The longest ARIs were located at the sites of earliest activation and shortest at the latest activation areas, with gradual shortening between them. Conclusions The spatial distribution of repolarization is dependent on the activation pattern. Repolarization dispersion in the healthy swine heart is relatively small as the result of tight coupling of the action potential duration to the activation process, assigning longer ARIs to sites activated earlier. This coupling reduces global and regional dispersion of repolarization and may serve as an important antiarrhythmic mechanism present in normal myocardium.
"Downwinders" Angry About Medical Screening Lack
Authors: Andrew A. Skolnick
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of transesophageal echocardiography in identifying anomalous coronary arteries.
Authors: F Fernandes, M Alam, S Smith, F Khaja
Journal: Circulation (1993)

BACKGROUND The study objective was to evaluate the role of transesophageal echocardiography in identifying the origin of anomalous coronary arteries and confirming their course in relation to the great vessels. The diagnosis of coronary anomalies is made by angiography. The anomalous left main artery with a course between the pulmonary artery and the aorta has been associated with myocardial infarction and sudden death. The course of these anomalous coronary arteries is difficult to demonstrate by angiography alone. METHODS AND RESULTS Nine patients with angiographically confirmed anomalous coronary arteries were studied by transesophageal echocardiography with color flow Doppler. The abnormal origin of the anomalous coronary arteries was confirmed by transesophageal echocardiography in all nine patients. In four patients, the left main coronary artery originated from the right sinus of Valsalva. In all of these patients, transesophageal echocardiography demonstrated the course of the anomalous left main coronary artery between the aorta and pulmonary artery better than angiography. Other anomalies that were visualized included two patients with origin of the right coronary arteries from the left aortic sinus, one patient with origin of the left anterior descending from the right sinus, one patient with origin of circumflex from the right sinus, and one patient with origin of the left main coronary artery from the pulmonary artery. CONCLUSIONS Transesophageal echocardiography is a useful noninvasive test for diagnosing anomalous origin of the coronary arteries. Furthermore, it is a valuable adjunct to angiography in demonstrating the abnormal course of the left main coronary artery interposed between the aorta and the pulmonary artery, a potentially life-threatening entity.
Natural Course of Remission in IDDM During 1st yr After Diagnosis
Authors: Stephen Martin, Brigette Pawlowski, Burkard Greulich, Anette G Ziegler, Thomas Mandrup-Poulsen, Jeffrey Mahon
Journal: Diabetes Care (1992)

Objective –To describe the natural course of clinical remission in insulin-dependent diabetes mellitus (IDDM) when insulin dose is minimized without loss of target glycemia and to identify factors that predict clinical remission. Research Design and Methods –Ninety-five patients, who were placebo-treated control subjects in the Canadian-European multicenter randomized trial of cyclosporin A in recent-onset IDDM, were studied. Results –The mean insulin dose decreased during the first months after diagnosis, with a nadir at 3 mo, when 27% of the patients did not require insulin to maintain target glycemia. At 1 yr, 10% of patients still did not need insulin. Patients not receiving insulin who had glycosylated hemoglobin within the normal range were called remitters. Mean basal and glucagon-stimulated C-peptide values were significantly (P &amp;lt; 0.025) higher in remitters than nonremitters at the start of the study. Therefore, all patients were divided into those with values above the mean stimulated C-peptide (0.4 nM) and those with values below the mean at entry. The probability of entering a remission with a stimulated C-peptide &amp;gt; 0.4 nM was 10 times as high (P &amp;lt; 0.05) as for those with a stimulated C-peptide below this level. Surprisingly, the beginning and end of the remission were associated with neither major changes in C-peptide levels nor islet cell antibody and insulin-antibody titer. A more rapid loss of stimulated C-peptide occurred in patients who lacked HLA-DR3 and -DR4 (P &amp;lt; 0.05 at mo 9). Conclusions –This study shows a higher spontaneous clinical remission rate than expected during the 1st yr after diagnosis. Preserved beta-cell function at entry predicts a greater chance of entering a remission, and a more rapid loss of beta-cell function was seen in patients without HLA-DR3 and -DR4.
1010-140 Influence of surgical treatment of atrial fibrillation on late morbi-mortality after correction of mitral valve lesions associated with chronic atrial fibrillation
Authors: Renato A.k Kalil, Gustavo G Lima, Daniel L Faria-Corrêa, Rogério Abrahão, Maurice Formigheri, Marcelo Miglioransa, Gustavo Vanni, Paulo R Prates, João R.M Sant'Anna, Ivo A Nesralla
Journal: Journal of the American College of Cardiology (2004)
The profiles of interleukin (IL)‐2, IL‐6, and interferon‐gamma production by peripheral blood mononuclear cells from house‐dust‐mite‐allergic patients: a role for IL‐6 in allergic disease
Authors: S. M. McHugh, A. B Wilson, J. Deighton, P. J. Lachmann, P. W. Ewan
Journal: Allergy (1994)

We have developed a model to measure cytokine production by peripheral blood mononuclear cells (PBMC) in vitro. In this report, we examine the production of interleukin‐2 (IL‐2), IL‐6, and interferon‐gamma (IFN‐γ) by PBMC of house‐dust‐mite ( Dermatophagoides pteronyssinus )‐allergic subjects. When stimulated with specific allergen ( D. pteronyssinus ), PBMC of patients produced significant levels of IL‐2 and high levels of IL‐6, but little or no IFN‐γ. Nonatopic control PBMC also produced IL‐6, although at lower levels, but no IL‐2 or IFN‐γ. A ubiquitous antigen, streptokinase/streptodornase (SKSD), induced high levels of IL‐2 in patients, but only low levels of IFN‐γ and IL‐6. Nonatopic controls produced similar levels of IL‐2 and IL‐6, but high levels of IFN‐γ to SKSD. IL‐2 and IFN‐γ levels induced by the T‐cell mitogen phytohaemagglutinin (PHA) were similar in patient and control groups, but IL‐6 levels were significantly lower in the patients. IgE synthesis in vitro was shown only in atopic PBMC cultures stimulated with specific allergen. The major points can be summarized as 1) IL‐2 production by atopic patients in response to allergen; 2) IL‐6 production to allergen by both atopic and nonatopic patients, but significantly increased in atopic patients; and 3) defective IFN‐γ production by atopic patients to both allergen and antigen. These findings suggest that IL‐6 may be important in the immune response to inhalent allergens such as D. pteronyssinus , possibly by creating a cytokine environment favourable to a T H 2 response, and that atopic patients exhibit a generalized defect of IFN‐γ production, not related to the response to allergen.
Shared electronic patient records pose a serious threat to privacy, report says
Authors: M. Cross
Journal: BMJ (2009)

Substantial parts of the NHS’s IT infrastructure are in breach of human rights and law on data protection and should be redesigned or abandoned, says a study from privacy campaigners.

The study, of a range of governments databases, considers that the NHS’s shared electronic patient records, and in particular that part known as the Detailed Care Record, are as serious a threat to privacy as the national identity card programme and the DNA database held by the police. Several NHS systems with lower profiles also received severe criticism. 

The report was commissioned by the Joseph Rowntree Reform Trust, a funder of campaigns to promote political and democratic reform and defend civil liberties. It was written by a group …
The effect of oral propranolol upon the ECG changes occurring in subarachnoid haemorrhage
Authors: J. M. CRUICKSHANK, G. NEIL-DWYER, J. LANE
Journal: Cardiovascular Research (1975)

The effect of oral propranolol on the abnormal ECGs of six cases of subarachnoid haemorrhage (SAH) was investigated. The P wave peaking seen in three of the six cases was abolished. The short P-R interval observed in three of the six cases was lengthened, one markedly so, and seemed independent of changes in heart rate. T wave flattening seen in one case was abolished, while T wave inversion seen in one other was unaffected. T wave peaking seen in one case was increased with propranolol, but abolished by atropine. Tall U waves seen in two cases were diminished in amplitude and the Q-Tc (which was abnormally long in four) was shortened in all cases. Propranolol had no effect on the pathological Q waves which appeared in one case. It was concluded that these findings support the suggestion that P wave peaking, a short P-R interval, tall U waves and a long Q-Tc, often seen in ECGs of cases with SAH, are catecholamine-induced. Interplay between sympathetic and parasympathetic activity occurs in SAH with T wave peaking resulting from increased vagal tone. Catecholamine-induced cardiotoxic effects can cause ECG patterns mimicking myocardial infarction and may, in some cases, contribute to increased morbidity and mortality. There is thus a need for a controlled blind trial of prophylactic oral propranolol in SAH.