tbuckley/cabot-search huggingface dataset:
Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis
Authors: Sigrid Elsenbruch, Jost Langhorst, Kalina Popkirowa, Twyla Müller, Rainer Luedtke, Ulla Franken, Anna Paul, Günther Spahn, Andreas Michalsen, Onno E. Janssen, Manfred Schedlowski, Gustav Dobos
Journal: Psychotherapy and Psychosomatics (2005)

&lt;i&gt;Background:&lt;/i&gt; The aim of this study was to investigate the effects of mind-body therapy on neuroendocrine and cellular immune measures, health-related quality of life and disease activity in patients with ulcerative colitis (UC) in remission. &lt;i&gt;Methods:&lt;/i&gt; Thirty UC patients in remission or with low disease activity were randomly assigned to an intervention group (n = 15) or a usual-care waiting control group (n = 15). Intervention consisted of a structured 60-hour training program over 10 weeks which included stress management training, moderate exercise, Mediterranean diet, behavioral techniques and self-care strategies. Quality of life, perceived stress and disease activity were assessed with standardized questionnaires (IBDQ, SF-36, PSS, CAI). In addition, the distribution of circulating lymphocytes and lymphocyte subsets as well as the β-adrenergic modulation of TNF-α production in vitro were analyzed. Urine catecholamines and plasma cortisol, prolactin and growth hormone were measured pre- and postinterventionally, and were compared with a healthy control group (n = 10). &lt;i&gt;Results:&lt;/i&gt; In response to therapy, patients in the intervention group showed significantly greater improvement in the SF-36 scale Mental Health and the Psychological Health Sum score compared with changes observed in the usual-care waiting control group. Patients in the intervention group showed significantly greater improvement on the IBDQ scale Bowel Symptoms compared with the control group. However, no significant group differences in circulating lymphocyte subsets or endocrine parameters were observed in response to therapy. In addition, no significant effects of intervention on either the basal levels of TNF-α or the suppressive action of the β-adrenergic agonist isoproterenol on TNF-α production were observed. &lt;i&gt;Conclusion:&lt;/i&gt; Mind-body therapy may improve quality of life in patients with UC in remission, while no effects of therapy on clinical or physiological parameters were found, which may at least in part be related to selective patient recruitment.
PTU-051 Donor morbidity following living donor liver transplantation (LDLT): outcome from a small volume centre
Authors: A Hakeem, S Raza, M Reddy, J Jeffery, E Hidalgo, M Attia, S Pollard, G Toogood, C Millson, J P A Lodge, K R Prasad
Journal: Gut (2012)

<h3>Introduction</h3> Living Donor Liver Transplantation (LDLT) has grown immensely in certain countries over the last few years, whereas in West the growth remains static and low volume. Donor morbidity following LDLT has been reported in the median range of 15%–30% in various studies. One of the limiting factor for the growth of LDLT has been the concerns with morbidity and mortality during a centres initial experience. We report the donor outcome from a small volume centre, so as to assess if there is an impact on volume with donor outcome. <h3>Methods</h3> Between June 2007 and December 2011, 25 LDLT procedures were carried out in our unit. The criteria for donor selection included age, fitness for surgery and remnant liver volume. Donor demographics, graft type, complications, length of stay and overall survival were extracted. Donor morbidity was assessed objectively using the modified Clavien-Dindo classification. Continuous variables are expressed as mean ± SD. <h3>Results</h3> The mean donor age was 38.4±11.0 years and donor BMI was 23.9±2.8 kg/cm<sup>2</sup>. Two donors were abandoned on table due to complex arterial and biliary anatomy respectively. The graft type was right lobe (n=12, 52.2%), left lateral lobe (n=10, 43.5%) and left lobe (n=1, 4.3%). The graft weight was 528.5±258.9 g. The morbidity was 21.7% (n=5). There were three Clavien grade II complications (wound infection, urinary infection and unknown sepsis needing antibiotics). One patient needed laparotomy for haemorrhage (Grade IIIb) and another patient had ultrasound guided drainage of subphrenic collection (Grade IIIa). None of our patients had any post-operative blood transfusion. The length of hospital stay was 7.9±2.8 days. At the end of median follow-up of 21.4 months, all our donors were alive, with no long-term morbidity. <h3>Conclusion</h3> Our experience shows that donor hepatectomy for Living Donor Liver Transplantation is a safe procedure in a small volume unit. Our donor morbidity of 21.7% is comparable or better than most high volume centres across the world. Number of procedures performed by the unit shouldn9t be an hindrance to the introduction of live donor liver programme. <h3>Competing interests</h3> None declared.
Lead in calcium supplements.
Authors: G M Scelfo, A R Flegal
Journal: Environmental Health Perspectives (2000)

Intercalibrated measurements of lead in calcium supplements indicate the importance of rigorous analytical techniques to accurately quantify contaminant exposures in complex matrices. Without such techniques, measurements of lead concentrations in calcium supplements may be either erroneously low, by as much as 50%, or below the detection limit needed for new public health criteria. In this study, we determined the lead content of 136 brands of supplements that were purchased in 1996. The calcium in the products was derived from natural sources (bonemeal, dolomite, or oyster shell) or was synthesized and/or refined (chelated and nonchelated calcium). The dried products were acid digested and analyzed for lead by high resolution-inductively coupled plasma-mass spectrometry. The method's limit of quantitation averaged 0.06 microg/g, with a coefficient of variation of 1.7% and a 90-100% lead recovery of a bonemeal standard reference material. Two-thirds of those calcium supplements failed to meet the 1999 California criteria for acceptable lead levels (1.5 microg/daily dose of calcium) in consumer products. The nonchelated synthesized and/or refined calcium products, specifically antacids and infant formulas, had the lowest lead concentrations, ranging from nondetectable to 2.9 microg Pb/g calcium, and had the largest proportion of brands meeting the new criteria (85% of the antacids and 100% of the infant formulas).
Solitary angiodysplastic lesions in the ileocaecal region diagnosed by angiography
Authors: G. H. Whitehouse
Journal: Gut (1973)

Single angiodysplasias were demonstrated by preoperative angiography in four patients. In two cases the lesions were in the terminal ileum, and were situated just above the caecum in the other two patients. In three patients, contrast medium was extravasated into the bowel lumen. Histological verification was obtained in three instances. The literature on intestinal angiodysplastic lesions was reviewed, with especial regard to their distribution and radiological manifestations. The relative frequency of angiodysplasias in the right side of the colon is noted. Visceral angiography is an important investigation in cases where there is persistent or recurrent bleeding from the gastrointestinal tract, especially when barium studies and laparatomy have been negative.
A-bomb data: detection of bias in the Life Span Study cohort.
Authors: A Stewart
Journal: Environmental Health Perspectives (1997)

By drawing a distinction between A-bomb survivors with and without bomb-related injuries, it was possible to see that instead of the Life Span Study (LSS) cohort being a normal, homogenous population, there were significant differences between survivors with and without multiple injuries, and that these differences occurred largely among survivors who were under 10 or over 50 years of age when exposed. There also was a concentration of A-bomb-related injuries among survivors who eventually developed leukemia. So it is possible that deaths before 1950 had left the LSS cohort permanently biased in favor of persons who had high levels of resistance to all (early and late) effects of radiation. It is also possible that the high proportion of leukemia cases among the deaths of A-bomb survivors from 1950 to 1970 were because the radiation caused an initial leukocytosis followed by loss of immunologic competence.
Amino acid derivative-mediated detoxification and functionalization of dual cure dental restorative material for dental pulp cell mineralization
Authors: Hajime Minamikawa, Masahiro Yamada, Fuminori Iwasa, Takeshi Ueno, Yoshiaki Deyama, Kuniaki Suzuki, Yasutaka Yawaka, Takahiro Ogawa
Journal: Biomaterials (2010)
THE USE OF BETA RAYS IN THE TREATMENT OF CHRONIC ECZEMA AND PSORIASIS A PRELIMINARY REPORT
Authors: R. H. MACDONALD, D. G. BRATHERTON
Journal: British Journal of Dermatology (1970)

SUMMARY. Twenty-four patients with resistant patches of eczema and 6 patients with resistant patches of psoriasis have been treated with beta rays using a Strontium 90 source. The results are discussed and compared with those obtained with other similar methods of treatment. It is concluded that in carefully selected patients with benign dermatoses beta ray therapy from a Strontium 90 source is safe and effective.
Fatal Carbon Monoxide Poisoning at a Motel
Authors: Melinda Wharton
Journal: JAMA (1989)

One man died and four other persons required hospitalization following accidental exposure to carbon monoxide at a motel. In spite of prompt diagnosis of the index cases, a search for the source of exposure and for other possible victims was delayed more than ten hours. Subsequent investigation revealed that air conditioning units drew carbon monoxide from the gas heaters for the motel's indoor swimming pools into three adjacent guest rooms through structural defects in the walls. Emergency care providers must remember that in environmental exposures, other persons may continue to be at risk, and efforts must be made to identify them.
Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in platelet-reduced blood under flow conditions
Authors: Kazuhiko Tomokiyo, Yuichi Kamikubo, Takako Hanada, Tatsuya Araki, Yasushi Nakatomi, Yoichi Ogata, Stephanie M. Jung, Tomohiro Nakagaki, Masaaki Moroi
Journal: Blood (2005)
Intracerebral Bacillary Angiomatosis in HIV
Authors: Pamela Jo Harris
Journal: Annals of Internal Medicine (1992)

Letters1 November 1992Intracerebral Bacillary Angiomatosis in HIVPamela Jo Harris, MDPamela Jo Harris, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-9-795_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: I read with interest Spach and colleagues' first reported case of intracerebral bacillary angiomatosis in a patient infected with human immunodeficiency virus (1). We report a similar occurrence in a 37-year-old white male homosexual patient with the acquired immunodeficiency syndrome (AIDS) who presented in July 1990 with low-grade fever, dyspnea, and cough. Physical examination showed bilateral rales; chest radiographs and gallium scan results were compatible with a diagnosis of Pneumocystitis carinii pneumonia. The patient was treated with pentamidine, zidovudine, and steroids, resulting in resolution of clinical and radiologic findings.Several weeks later, the patient presented with abdominal...Reference1. SpachPantherThorningDunnPlordeMiller DLDJJR. Intracerebral bacillary angiomatosis in a patient infected with human immunodeficiency virus. Ann Intern Med. 1991;116:740-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Pamela Jo Harris, MDAffiliations: 1810 Calvert Street, NW Suite Number Five Washington, DC 20009 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDetection of Bartonella henselae by polymerase chain reaction in brain tissue of an immunocompromised patient with multiple enhancing lesionsHuman infection with Bartonella speciesBartonella spp. as emerging human pathogensBacillary angiomatosis in an HIV seronegative patient on systemic steroid therapyBacillary angiomatosisInter- and intraspecies identification of Bartonella (Rochalimaea) speciesCat Scratch Disease, Bacillary Angiomatosis, and Other Infections Due to RochalimaeaIsolation and characterization by immunofluorescence, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, western blot, restriction fragment length polymorphism-PCR, 16S rRNA gene sequencing, and pulsed-field gel electrophoresis of Rochalimaea quintana from a patient with bacillary angiomatosis 1 November 1992Volume 117, Issue 9Page: 795-795KeywordsAIDSAngiomatosisDyspneaFeversGallium scanHIV-1HomosexualsPneumoniaSteroidsThorax ePublished: 1 December 2008 Issue Published: 1 November 1992 PDF downloadLoading ...
Reaginic hypersensitivity in ulcerative colitis
Authors: D. P. Jewell, S. C. Truelove
Journal: Gut (1972)

Reaginic hypersensitivity in ulcerative colitis has been investigated in respect of a hypersensitivity to the cow9s milk proteins and the frequency of atopic asthma, hay fever, and eczema. Intradermal tests were frequently positive, especially to casein, but the results did not differ from those found in healthy individuals and in groups of patients with Crohn9s disease, hypolactasia, and the irritable colon syndrome. No circulating IgE-specific antibodies to the milk proteins were found. An increased frequency of atopic diseases was found in patients suffering from ulcerative colitis (15·7%) and Crohn9s disease (13·3%) compared with the findings in a control group (1·2%). It is concluded that, if an allergy to milk proteins is a factor in the pathogenesis of ulcerative colitis, it is not mediated by reaginic antibodies. It is possible, however, that the frequent occurrence of atopy indicates a susceptibility to develop reaginic responses even though this mechanism does not apply to the milk proteins.
Rehabilitation after head injury: 2--behaviour and emotional problems, long term needs, and the requirements for services.
Authors: D Gloag
Journal: BMJ (1985)

Psychiatrie symptoms and less stable patterns of behaviour are common after severe head injury.1 Character change and difficult behaviour are among the most tragic consequences. Sometimes they represent not so much a change of personality as exaggeration of previous adverse traits. In a family they cause immense stress and depression,1 calling at the least for careful counselling and support.2 Behavioural disorders clearly may sabotage rehabilitation as well as jeopardising the future quality of life.
Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target
Authors: Roger S. Smith, Barbara H. Iglewski
Journal: Journal of Clinical Investigation (2003)

Pseudomonas aeruginosa has two complete quorum-sensing systems. Both of these systems have been shown to be important for Pseudomonas virulence in multiple models of infection. Thus, these systems provide unique targets for novel antimicrobial drugs.
Analysis of ethnic differences in perinatal statistics.
Authors: P B Terry, R G Condie, R S Settatree
Journal: BMJ (1980)

The 3996 mothers delivered at Dudley Road Hospital, Birmingham, in 1979 were analysed for their ethnic origins. Social classes IV and V predominated in all groups. A high proportion of Indian mothers fell into the low-risk group based on age and parity but had the highest stillbirth and perinatal mortality rates (15.1 and 27.5/1000 respectively) and infants of low mean birth weight (2986 g). Elderly and multiparous mothers were characteristic of the Pakistani and Bangladeshi groups. Young, primiparous mothers were more common among the West Indians and Europeans, in whom the stillbirth and perinatal mortality rates were low; infants in the European group had a mean birth weight higher than in any other group (3231 g). From these findings ethnic origin of the mother is apparently an important factor in perinatal mortality.
Autologous transfusion-transmitted Yersinia enterocolitica
Authors: C. Richards
Journal: JAMA (1992)

To the Editor.  —With the heightened public awareness of the potential risks for transfusion-transmitted diseases, both patients and physicians are more knowledgeable of the benefits of autologous donation/transfusion. In California, physicians are required by law to inform patients of transfusion options, including autologous and directed donations. Although autologous donations decrease the risk of transfusion-transmitted disease by decreasing homologous blood exposure, autologous transfusion is not without risk. The following is a report of transfusion-transmitted Yersinia enterocolitica illness from a unit of autologous blood transfused 41 days after collection.  A 74-year-old man with a 4-year history of osteoarthritis donated 4 units of autologous blood for a total knee replacement surgery. Each unit was collected 1 week apart. The patient completed a medical history under the direction of a registered nurse and indicated no bacterial infection. The patient was afebrile at the time of all donations and had no history of dental work
Impact of the seven-valent pneumococcal conjugate vaccination (PCV7) programme on childhood hospital admissions for bacterial pneumonia and empyema in England: national time-trends study, 1997-2008
Authors: E. Koshy, J. Murray, A. Bottle, M. Sharland, S. Saxena
Journal: Thorax (2010)

Childhood bacterial pneumonia and empyema rates have reportedly increased in recent years in Europe. In September 2006 the seven-valent pneumococcal conjugate vaccination (PCV7) was introduced to the childhood national immunisation programme in England following a successful PCV7 campaign in the USA. The aim of this study was to report national time trends in hospital admissions for childhood bacterial pneumonia and empyema in England before and after the introduction of PCV7.A population-based time-trend analysis of Hospital Episode Statistics data of children aged <15 years admitted to all NHS hospitals in England, with a primary diagnosis of bacterial pneumonia and empyema from 1997 to 2008 was performed. Annual crude and age-sex standardised hospital admission rates for bacterial pneumonia and empyema were calculated.Admission rates for bacterial pneumonia and empyema increased from 1997 to 2006, then declined to 2008. Bacterial pneumonia rates decreased to 1079 (95% CI 1059 to 1099) per million children and empyema rates decreased to 14 (95% CI 11 to 16) per million children. The RR for bacterial pneumonia admissions was 1.19 (95% CI 1.16 to 1.22) in 2006 compared with 2004 and 0.81 (95% CI 0.79 to 0.83) in 2008 compared with 2006. For empyema, the corresponding RRs were 1.77 (95% CI 1.38 to 2.28) in 2006 compared with 2004 and 0.78 (95% CI 0.62 to 0.98) in 2008 compared with 2006.Childhood bacterial pneumonia and empyema admission rates were increasing prior to 2006 and decreased by 19% and 22% respectively between 2006 and 2008, following the introduction of the PCV7 pneumococcal conjugate vaccination to the national childhood immunisation programme.
THE VITAMIN B1 AND B2 G CONTENT OF LIVER EXTRACT AND BREWERS' YEAST CONCENTRATE
Authors: D. K. Miller, C. P. Rhoads
Journal: The Journal of Experimental Medicine (1934)

1. Liver extract powder, No. 343 Lilly, and the same material prepared for parenteral use, when administered daily by mouth in amounts derived from 2.5 gm. of fresh whole liver, to rats weighing from 40 to 50 gm., contain sufficient vitamin B(1) to support normal growth, provided the animals receive in addition an adequate amount of vitamin B(2) G. Moreover, liver extract in the forms mentioned, administered in the same amounts, does not contain sufficient vitamin B(2) G to maintain normal growth of similar rate when all other necessary constituents of the diet are provided. 2. Liver extract (Lilly) in the form prepared for parenteral use, when administered daily by intraperitoneal injections, in amounts derived from 2.5 gm. of fresh whole liver, to rats under standard experimental conditions, does not contain sufficient vitamin B(2) G to maintain normal growth. Furthermore, the amount of vitamin B(1) present in liver extract in this form is not as effective in supporting normal growth when given by intraperitoneal injection as it is when given by mouth. 3. Vegex, when administered daily in amounts of 50, 150, and 250 mg. to rats of 40 to 50 gm. in weight contains sufficient vitamin B(1) to maintain normal growth of the rats, provided the animals receive in addition an adequate amount of vitamin B(2) G. However, vegex in the same amounts does not contain sufficient vitamin B(2) G to support normal growth of similar rats when all other necessary constituents of the diet are provided. 4. These experiments indicate that the extrinsic, anti-anemic factor of Castle and the thermostable growth-promoting food constituent, commonly known as vitamin B(2) G, are not identical.
The Placebo Effect in Psychiatric Drug Research
Authors: Armand W. Loranger
Journal: JAMA (1961)

A drug investigation involving 120 hospitalized psychiatric patients was simulated. It appeared to participating patients, psychiatrists, and nurses, that a new tranquilizer and a new energizer were to be evaluated, but both "drugs" were actually placebos. According to uncontrolled and subjective methods of evaluation, 53% to 80% of the patients benefited from the new "drugs." When matched control groups and objective rating scales were used in the evaluation, a temporary improvement was caused by the tranquilizer but not by the energizer. The tendency to attribute improvement to what were thought to be active drugs, and the discrepancy in one experiment between controlled and uncontrolled methods of evaluation, dramatically illustrates the dubious value of studies which do not employ double-blind and other controlled procedures.
CHRONIC INFECTIONAL EDEMA
Authors: FRANKLIN A. STEVENS
Journal: JAMA (1933)

Ten years after Fehleisen<sup>1</sup>isolated the streptococcus from the skin lesions of erysipelas, Sabouraud<sup>2</sup>obtained cultures of streptococcus from patients with recurrent erysipelas and elephantiasis. Subsequent pathologic studies of the diseased tissues convinced both Sabouraud and Unna<sup>3</sup>that the edema and fibrosis which they found in the microscopic sections were not the result of circumscribed obstruction to the lymphatics, as in filarial elephantiasis, but to local changes in the tissues. Although they disagreed in some particulars regarding the mechanism underlying the pathogenesis of the edema and fibrosis, they agreed that repeated streptococcic infections which kept the cells bathed in the products of bacterial disintegration that were not adequately drained away were responsible for the pathologic condition. While Sabouraud attributed the hypertrophy solely to streptococcic infection, instances of chronic or recurrent infections with staphylococcus<sup>4</sup>as well as streptococcus<sup>5</sup>causing similar edema and fibrosis have been reported
Disproportional upregulation of matrix metalloproteinase to tissue inhibitor of metalloproteinase genes in abdominal aortic aneurysm: Results from quantitative real-time RT-PCR method
Authors: Takeo Higashikata, Masakazu Yamagishi, Hiroaki Sasaki, Hitoshi Ogino, Aiji Sakamoto
Journal: Journal of the American College of Cardiology (2003)