tbuckley/cabot-search huggingface dataset:
Effect of virtual reality training on laparoscopic surgery: randomised controlled trial
Authors: C. R Larsen, J. L Soerensen, T. P Grantcharov, T. Dalsgaard, L. Schouenborg, C. Ottosen, T. V Schroeder, B. S Ottesen
Journal: BMJ (2009)

<b>Objective</b> To assess the effect of virtual reality training on an actual laparoscopic operation. <b>Design</b> Prospective randomised controlled and blinded trial. <b>Setting</b> Seven gynaecological departments in the Zeeland region of Denmark. <b>Participants</b> 24 first and second year registrars specialising in gynaecology and obstetrics. <b>Interventions</b> Proficiency based virtual reality simulator training in laparoscopic salpingectomy and standard clinical education (controls). <b>Main outcome measure</b> The main outcome measure was technical performance assessed by two independent observers blinded to trainee and training status using a previously validated general and task specific rating scale. The secondary outcome measure was operation time in minutes. <b>Results</b> The simulator trained group (n=11) reached a median total score of 33 points (interquartile range 32-36 points), equivalent to the experience gained after 20-50 laparoscopic procedures, whereas the control group (n=10) reached a median total score of 23 (22-27) points, equivalent to the experience gained from fewer than five procedures (P&lt;0.001). The median total operation time in the simulator trained group was 12 minutes (interquartile range 10-14 minutes) and in the control group was 24 (20-29) minutes (P&lt;0.001). The observers' inter-rater agreement was 0.79. <b>Conclusion</b> Skills in laparoscopic surgery can be increased in a clinically relevant manner using proficiency based virtual reality simulator training. The performance level of novices was increased to that of intermediately experienced laparoscopists and operation time was halved. Simulator training should be considered before trainees carry out laparoscopic procedures. <b>Trial registration</b> ClinicalTrials.gov NCT00311792.
Obesity in mice with adipocyte-specific deletion of clock component Arntl
Authors: Georgios K Paschos, Salam Ibrahim, Wen-Liang Song, Takeshige Kunieda, Gregory Grant, Teresa M Reyes, Christopher A Bradfield, Cheryl H Vaughan, Michael Eiden, Mojgan Masoodi, Julian L Griffin, Fenfen Wang, John A Lawson, Garret A FitzGerald
Journal: Nature Medicine (2012)
Which right atrial site is better for burst overstimulation of acute atrial fibrillation and atypical atrial flutter?
Authors: Nikolay Shlevkov, Alexander Yang, Rainer Schimpf, Helga Bielik, Jan Schrickel, Alexander Bitzen, Jörg O. Schwab, Berndt Lüderitz, Thorsten Lewalter
Journal: Journal of the American College of Cardiology (2003)
Bone histology in patients with nephrotic syndrome and normal renal function
Authors: Sanjeev K. Mittal, Suresh C. Dash, Suresh C. Tiwari, Sanjay K. Agarwal, Sanjeev Saxena, Steven Fishbane
Journal: Kidney International (1999)

Bone histology in patients with nephrotic syndrome and normal renal function. <h3>Background</h3> The prevalence of metabolic bone disease in patients with nephrotic syndrome (NS) at normal level of renal function remains uncertain. <h3>Methods</h3> To address this issue, we studied 30 patients (20 men and 10 women, mean age 27.3±11.7years) with NS who had normal renal function (mean creatinine clearance 103±4ml/min). We evaluated their serum calcium, phosphorus, alkaline phosphatase, immunoreactive parathyroid hormone (iPTH), vitamin D metabolites, urinary calcium, and skeletal survey. The extent of bone mineralization was analyzed by histomorphometric analysis of iliac crest bone biopsy specimens in all patients. The findings on bone histology were correlated with biochemical parameters. <h3>Results</h3> The mean duration of NS was 35.5±26.9months, with a protein excretion of 7.3±3.2g/24hr and a serum albumin of 2.2±0.8g/dl. Total serum calcium was 7.8±0.8mg/dl, whereas ionized calcium was 5.7±0.7mg/dl, phosphorus 3.2±1.2mg/dl, and alkaline phosphatase 149±48.6 U/liter. Serum iPTH levels were normal in all except two patients. The mean serum 25-hydroxyvitamin D [25(OH)D] level was 3.9±1.2ng/ml (normal 15 to 30ng/ml), whereas 1,25-dihydroxyvitamin D was 24±4.7pg/ml (normal 16 to 65). There was an inverse correlation between serum levels of 25(OH)D and the magnitude of proteinuria (<i>r</i> = −0.42, <i>P</i> < 0.05). The mean 24-hour urinary calcium excretion was 82±21mg/day. The skeletal survey was normal in all patients. Bone histology was normal in 33.3% of the patients, whereas 56.7% had isolated osteomalacia (OSM), and 10% had an increased bone resorption in association with defective mineralization. The severity of OSM measured by mineralization lag time correlated linearly with the duration (<i>r</i> = 0.94, <i>P</i> < 0.0001) and the amount(<i>r</i> = 0.94, <i>P</i> < 0.0001) of proteinuria. All patients with NS for more than three years had histological changes. Patients with OSM had lower 25(OH)D and serum albumin as compared with those with normal histology (<i>P</i> < 0.005). Bone mineralization had no significant correlation with serum iPTH, divalent ions, or vitamin D levels. <h3>Conclusions</h3> OSM is a frequent finding in adult patients with NS, even at a normal level of renal function. Its severity correlates with the amount and duration of proteinuria.
Remarks on THE GALL-BLADDER IN RELATION TO FOCAL INFECTION
Authors: D. P. D. Wilkie
Journal: BMJ (1929)

GALL-BRLADDFr(R disease; comnmands out1r attention from thiree asl)ets-namely: (1) As a cause of recurrent acute al)(lontminal pain. (2)As a cause of persisten1t reflex flatuilent dy spepsia. (3)As a focus from1 i which inifection spIrea(s to various organs anid tissurs, thrcughout the body.With biliary colic anid with gall-bladder (dyspep)sia we are all thoroughly familiar, aindi cldo iot propose touclh oni these subjects, nor0 w%ill I refer to complications such as obstrnctive j'aundice a(d p)ancreatitis.Our con1cerni * Pe.rt of adrdrcss (%vitli de'monstration)the Southi I's-leeand Monmouthslhire Branch at Portheawl on May 16th, 1929.r Tsx BssU 37 L MRDICAL JoUnLaL prove fatal.The B. coli, athough not infrequely found in acute obstructive cholecystitis, proved in ouir expe- rience to be a rare type of infection chronic gall-bladder disease.
Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper
Authors: Haifa Hamdi, Véronique Godot, Marie-Christine Maillot, Maria Victoria Prejean, Nicolas Cohen, Roman Krzysiek, François M. Lemoine, Weiping Zou, Dominique Emilie
Journal: Blood (2007)
Channel structure and divalent cation regulation of phototransduction
Authors: Richard L. Hurwitz, Devesh Srivastava, Mary Y. Hurwitz
Journal: Behavioral and Brain Sciences (1995)

Abstract The identification of additional subunits of the cGMP-gated cation channel suggests exciting questions about their regulatory roles and about structure/functional relationships. How do the different subunits interact? How is the complex assembled into the plasma membrane? Divalent cations have been implicated in the regulation of adaptation. One often overlooked cation is magnesium. Could this ion play a role in phototransduction?
Hematopoietic Progenitor Cell Rolling in Bone Marrow Microvessels: Parallel Contributions by Endothelial Selectins and Vascular Cell Adhesion Molecule 1
Authors: Irina B. Mazo, Jose-Carlos Gutierrez-Ramos, Paul S. Frenette, Richard O. Hynes, Denisa D. Wagner, Ulrich H. von Andrian
Journal: The Journal of Experimental Medicine (1998)

We have used intravital microscopy to study physiologically perfused microvessels in murine bone marrow (BM). BM sinusoids and venules, but not adjacent bone vessels, supported rolling interactions of hematopoietic progenitor cells. Rolling did not involve L-selectin, but was partially reduced in wild-type mice treated with antibodies to P- or E-selectin and in mice that were deficient in these two selectins. Selectin-independent rolling was mediated by α4 integrins, which interacted with endothelial vascular cell adhesion molecule (VCAM)-1. Parallel contribution of the endothelial selectins and VCAM-1 is not known to direct blood cell trafficking to other noninflamed tissues. This combination of constitutively expressed adhesion molecules may thus constitute a BM-specific recruitment pathway for progenitor cells analogous to the vascular addressins that direct selective lymphocyte homing to lymphoid organs.
Schönlein-Henoch Purpura
Authors: W. E. Keiter
Journal: JAMA (1964)

<h3>To the Editor:—</h3> A communication in the Aug 10 issue ofThe Journal(<b>185</b>:535, 1963) on Eduard Heinrich Henoch mentions that Ulster was the first to suggest the allergic nature of nonthrombocytopenic purpura. My search for documentation of this statement has been in vain, and I wonder if an original reference to this work of Ulster can be supplied.
1183 GENETIC VARIATION IN THE PNPLA3 GENE IS ASSOCIATED WITH ALCOHOLIC LIVER INJURY IN CAUCASIANS
Authors: F. Stickel, S. Buch, K. Lau, H. Meyer zu Schwabedissen, T. Berg, M. Ridinger, S. Wiegandt, M. Rietschel, C. Schafmayer, F. Braun, H. Hinrichsen, R. Günther, A. Arlt, M. Seeger, S. Mueller, H.K. Seitz, M. Soyka, M. Lerch, F. Lammert, C. Sarrazin, R. Kubitz, D. Häussinger, C. Hellerbrand, J. Schölmerich, H. Wittenburg, D. Bröring, S. Schreiber, R. Spanagel, K. Mann, M. Krawczak, N. Wodarz, H. Völzke, J. Hampe
Journal: Journal of Hepatology (2010)
Clinical Remarks ON SOLITARY NON-PARASITIC CYSTS OF THE LIVER
Authors: J. Bland-Sutton
Journal: BMJ (1905)

MIEDICAL JOURNAL i i 67 demands not one whit less of care as to antiseptic precautions than is required of one before opening the abdomen, we sball get no further forward.When the practical obstetrician realizes his responsibility, and that no small share of this terrible maternal mortality of a certainty lies at his door, he
Memoirs of a Fortune Teller
Authors: Marian de Zeeuw
Journal: Annals of Internal Medicine (1998)

Ad Libitum1 November 1998Memoirs of a Fortune TellerMarian de ZeeuwMarian de ZeeuwRochester, NY 14607Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-9-199811010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail suitable for decorating ... Author, Article, and Disclosure InformationAffiliations: Rochester, NY 14607Corresponding Author: Marian de Zeeuw, 270 South Goodman, #106, Rochester, NY 14607. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1998Volume 129, Issue 9Page: 746KeywordsForecastingSleep ePublished: 15 August 2000 Issue Published: 1 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Prevalence of hereditary thrombophilia in patients with thrombosis in different venous systems
Authors: Thomas Bombeli, Adila Basic, Joerg Fehr
Journal: American Journal of Hematology (2002)

The prevalence of hereditary thrombophilia is well known in patients with lower-extremity thrombosis but only poorly studied in patients with thrombosis at unusual sites. Consequently, it is still unclear whether such patients should generally be screened for hereditary thrombophilia. We retrospectively analyzed 260 patients with thrombosis at unusual sites including thrombosis in portal, cerebral, retinal, and upper-extremity veins with respect to the prevalence of FV Leiden, prothrombin G20210A, protein C, protein S, and antithrombin deficiency. In addition, all thrombotic episodes were analyzed for circumstantial risk factors. Used as controls, healthy volunteers (120) and patients with lower-extremity thrombosis (292) showed overall prevalence of hereditary thrombophilia of 9.1% and 39.0%, respectively. The corresponding numbers were 33.3%, 34.3%, and 39.0% in patients with portal vein, upper-extremity, and lower-extremity thrombosis, respectively. In patients with cerebral vein thrombosis, however, the prevalence was significantly lower (23.5%). Patients with retinal vein occlusion did not show an increased frequency of thrombophilia at all (5.9%). In all five groups FV Leiden was by far the most frequent defect (4.4-27.1%), while prothrombin G20210A occurred rarer (2.5-7.6%). Protein C, protein S, and antithrombin deficiency were much less prevalent (0-3.1%) except for patients with portal vein thrombosis (4.8-7.1%). Compared to healthy individuals, the relative risk of thrombosis was 4.3 (2.2-8.1), 3.8 (1.8-7.7), 2.5 (1.0-6.1), 3.7 (1.5-8.6), and 0.6 (0.2-2.1) for patients with lower-extremity, upper-extremity, cerebral vein, portal vein, and retinal vein thrombosis, respectively. Circumstantial risk factors were more frequent in patients without than with hereditary thrombophilia and were found most often in patients with upper-extremity thrombosis. In each group the most frequent circumstantial risk factor was different. However, oral contraceptives and cancer were found in all five groups. In conclusion, independent upon the presence of circumstantial risk factors, screening for hereditary thrombophilia is warranted in all patients with thrombosis at unusual sites except in those with retinal vein occlusion.
Cardiovascular Outcomes and the Physical and Chemical Properties of Metal Ions Found in Particulate Matter Air Pollution: A QICAR Study
Authors: Qingyu Meng, Jennifer Richmond-Bryant, Shou-En Lu, Barbara Buckley, William J. Welsh, Eric A. Whitsel, Adel Hanna, Karin B. Yeatts, Joshua Warren, Amy H. Herring, Aijun Xiu
Journal: Environmental Health Perspectives (2013)

This paper presents an application of quantitative ion character-activity relationships (QICAR) to estimate associations of human cardiovascular (CV) diseases (CVDs) with a set of metal ion properties commonly observed in ambient air pollutants. QICAR has previously been used to predict ecotoxicity of inorganic metal ions based on ion properties.
Whole blood aggregation in von willebrand disease
Authors: Joseph D. Sweeney, Lynne A. Hoernig, John E. Fitzpatrick
Journal: American Journal of Hematology (1989)

Abstract Platelet function testing in von Willebrand disease is generally performed in platelet rich plasma using an optical system. The characteristic abnormality is an abnormal response to the agglutinating agent, ristocetin. Platelet aggregation can be also studied in whole blood using either an impedance aggregometer or a particle counter. Fifteen patients with von Willebrand disease and fifteen normal subjects were studied using both whole blood methods. In the impedance system, normal subjects responded to ristocetin (1 mg/ml) with short lag phases (&lt;70 sec) and normal maximum aggregation (&gt;5 Ω). Only three patients with von Willebrand disease responded with normal maximal aggregation but each of these had a prolonged lag phase, and this may be a useful diagnostic parameter. In the particle counter, discrimination between normals and some von Willebrand disease patients was possible but an overlap between normals and von Willebrand patients is evident. It is concluded that the platelets in patients with von Willebrand disease exhibit the same abnormalities in whole blood as in platelet rich plasma and that the combination of impedance aggregometry and a factor VIII procoagulant assay is a time‐efficient and sensitive method to screen for von Willebrand disease.
Psychiatric Morbidity of Physicians
Authors: John C. Duffy, Edward M. Litin
Journal: JAMA (1964)

Physician health, both physical and mental, is an area of continuing interest and concern. From 1956 through 1963, 93 physicians were admitted to our in-patient psychiatric service. The spectrum of psychiatric illness in the group included organic brain syndromes (uncommonly), psychoses, psychoneurotic disorders, and personality pattern disturbances; alcoholism and drug addiction were fairly common. The physician-patient group is representative of the distribution of physicians by practice in our present-day society. Treatment in most instances consisted of psychotherapy, medication, and a supportive environment; electroconvulsive therapy was used in 18 cases.
A Trichomonas Species in a Mixed Microbial Meningitis
Authors: Henry Masur
Journal: JAMA (1976)

TRICHOMONADS are rarely demonstrated outside of the gastrointestinal or lower genitourinary tracts.<sup>1-3</sup>To our knowledge, the following case is the first report of a<i>Trichomonas</i>species isolated from the cerebrospinal fluid in a patient with meningitis. <h3>Report of a Case</h3> A 69-year-old man, formerly in good health, noted dysphagia in June 1975. In August 1975, he was referred to Memorial Sloan-Kettering Cancer Center, where findings from a physical examination were unremarkable. Laboratory examination included a hematocrit reading of 39% and a leukocyte count of 6,300/cu mm. Other laboratory tests were normal. Endoscopy showed an epidermoid carcinoma of the distal third of the esophagus. After a total dose of 2,000 rads of cobalt 60 to the anterior and posterior distal esophagus, the patient underwent exploration by thoracoabdominal approach on Aug 12. An infiltrating epidermoid carcinoma was resected with creation of an esophagogastrostomy. A splenectomy and distal pancreatectomy were also performed.
Enteritis Necroticans due to Clostridium Welchii Type F
Authors: J. Zeissler, L. Rassfeld-Sternberg, C. L. Oakley, C. Dieckmann, E. Hain
Journal: BMJ (1949)

BDIci'nuAL 267In the course of the next few days the inflammation spread down the thigh, chiefly on its anterior and medial aspects, as far as the knee.The skin was red and brawny, with a small necrotic
Antiemetic Properties of the Antiepileptic Drug Levetiracetam
Authors: Jong Woo Lee, Edward B Bromfield, Santosh Kesari
Journal: New England Journal of Medicine (2008)

To the Editor: Chemotherapy-induced nausea and vomiting is an important problem in patients with brain tumors. Because of the high prevalence of seizures, most patients are given antiepileptic drugs. Motivated by a case report,1 we investigated whether levetiracetam can suppress chemotherapy-induced nausea and vomiting. We retrospectively evaluated 161 patients with glioblastoma who had undergone radiation therapy and started adjuvant chemotherapy; 66 patients were taking levetiracetam and 95 were not (for all numerical data, see Table 1 in the Supplementary Appendix, available with the full text of this letter at www.nejm.org). In a univariate analysis, use of levetiracetam and older age were . . .
Landmark article, Nov 14, 1908: Results of the transplantation of blood vessels, organs and limbs. By Alexis Carrel
Authors: A. Carrel
Journal: JAMA (1983)

<h3>INTRODUCTION.</h3> The idea of replacing diseased organs by sound ones, of putting back an amputated limb or even of grafting a new limb on a patient having undergone an amputation, is doubtless very old. The performance of such operations, however, was completely prevented by the lack of a method of uniting vessels, thus re-establishing a normal circulation through the transplanted structures. The feasibility of these grafts depended on the development of the technic. The history of vascular surgery is too well known to need repetition. It recently reached the active stage of its development with the experiments of Murphy in Chicago and of Payr in Gratz. Murphy united the arteries by invagination and suture, while Payr used a magnesium tube. The remarkable experiments performed in 1903 by Hoepfner with the method of Payr gave an illustration of what could be obtained in vascular surgery by a proper method. Finally a
VITAMINS IN ICE CREAM
Authors: ARTHUR H. SMITH
Journal: JAMA (1922)

The study of the vitamins in ice cream has two points of value. In the first place, it adds an important item of a statistical nature to the evidence which is still accumulating concerning the accessory food factors; for the already large consumption of ice cream in the United States is on the increase, and popularity of the frozen sweet is bound to spread to other countries. Secondly, through the experiments here reported, one may estimate the effect of pasteurization and of freezing and storage on the vitamins in such a mixture as ice cream. The plan of the experiment was to test the ice cream for the various accessory food factors before freezing, and to repeat the tests on the same mixture after freezing. White rats were used in the tests for vitamins A and B, the technic of Ferry<sup>1</sup>being followed. For the antiscorbutic vitamin, the procedure
Characterization of skin infiltrating cells in adult T-cell leukaemia/lymphoma (ATLL): clinical, histological and immunohistochemical studies on eight cases
Authors: K. MAEDA, M. TAKAHASHI
Journal: British Journal of Dermatology (1989)

Eight cases of adult T-cell leukaemia/lymphoma (ATLL) with cutaneous involvement were studied. The clinical and histological features of these cases were recorded and immunohistochemistry carried out using a panel of monoclonal antibodies to T-cell differentiation antigens. Patients with ATLL showed distinct differences from patients with mycosis fungoides (MF) and Sézary syndrome (SS). Patients tended to have papulonodular and purpuric skin eruptions with pleomorphic lymphoid infiltrates, and often a degree of vasculitis. There was a high level of expression of activated T-cell antigens, CD25, CD30, CD38, T9 and Leu 8.
Toward Happier Hospitals — Teen-Age Troubles — The Hippocratic Oath
Authors: John Lister
Journal: New England Journal of Medicine (1961)

THERE has recently been a spate of advice from official sources on how to make patients happier in the hospital. A committee that set out to investigate the pattern of an inpatient's hospital day has concluded that the Victorian discipline under which patients and staff still labor in some hospitals is no longer a necessary condition for efficiency and hygiene. The long tradition of early waking of patients (still 5 a.m. in some hospitals) is particularly criticized, and it is suggested that, as far as possible, hospitals be made homes away from home. The time-honored treatment by rest has too . . .
Performance of bioprostheses and mechanical protheses assessed by composites of valve-related complications at 15 years for aortic valve replacement
Authors: W.R.Eric Jamieson, Olga von Lipinski, Eva Germann, Robert T. Miyagishima, Lawrence H. Burr, Michael T. Janusz, Hilton Ling, Guy Fradet
Journal: Journal of the American College of Cardiology (2003)
&lt;emph type="ital"&gt;White Poodle in a Punt&lt;/emph&gt;
Authors: Janet M. Torpy
Journal: JAMA (2009)

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