Amegakaryocytic Thrombocytopenic Purpura Treated with Antithymocyte Globulin
Authors: ABDERRAHIM KHELIF
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 May 1985Amegakaryocytic Thrombocytopenic Purpura Treated with Antithymocyte GlobulinABDERRAHIM KHELIF, MARTINE FFRENCH, GILLES FOLLEA, BERTRAND COIFFIER, MARC DECHAVANNE, JEAN-JACQUES VIALAABDERRAHIM KHELIF, MARTINE FFRENCH, GILLES FOLLEA, BERTRAND COIFFIER, MARC DECHAVANNE, JEAN-JACQUES VIALAAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-720_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Acquired amegakaryocytic thrombocytopenic purpura is an uncommon but serious bone marrow failure, characterized by isolated thrombocytopenia with absent or decreased megakaryocytes in the marrow. Recently published data (1) suggest the possibility of an autoimmune pathogenesis. The management of this disease is not established. Various treatments, such as corticoids, androgens, lithium, vincristine, and mercaptopurine, have been ineffective (1, 2). The potential usefulness of antithymocyte globulin in the treatment of various bone marrow failure states has led us to consider this agent in the management of acquired amegakaryocytic thrombocytopenic purpura.A 38-year-old man had a 2-month history of purpura...References1. HOFFMANBRUNOELWELL REJ. Acquired amegakaryocytic thrombocytopenic purpura: a syndrome of diverse etiologies. Blood. 1982;60:1173-8. CrossrefMedlineGoogle Scholar2. STOLLBLUMPASQUALEMURPHY DSDS. Thrombocytopenia with decreased megakaryocytes: evaluation and prognosis. Ann Intern Med. 1981;94:170-5. LinkGoogle Scholar3. COIFFIERVIALABRYONFIERE BJPD. Antithymocyte globulin in severe aplastic anaemia: how much? Lancet. 1983;2:100-1. CrossrefMedlineGoogle Scholar4. GEISSLERKONWALINKAPESCHEL DGC. Potential prescreening for therapeutic agents in a case of acquired amegakaryocytic thrombocytopenic purpura [Abstract]. Blut. 1984;49:237-8. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Hematology Hôpital Edouard Herriot 69374 Lyon France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in AdultsAcquired amegakaryocytic thrombocytopenic purpura: Review of a not very well-defined disorderAcquired amegakaryocytic thrombocytopenic purpura successfully treated with limited cyclosporin A therapySuccessful cyclosporin A therapy for acquired amegakaryocytic thrombocytopenic purpuraSuccessful treatment of acquired pure red cell aplasia and acquired amegakaryocytic thrombocytopenia with anti-thymocyte globulinSuccessful treatment with cyclosporin A in a child with acquired pure amegakaryocytic thrombocytopenic purpuraT suppressor activated lymphocytes (CD8 + /DR + ) inhibit megakaryocyte progenitor cell differentiation in a case of acquired amegakaryocytic thrombocytopenic purpuraAmegakaryocytic thrombocytopenia of 4 years duration: Successful treatment with antithymocyte globulinCYCLIC IDIOPATHIC PURE ACQUIRED AMEGAKARYOCYTIC THROMBOCYTOPENIC PURPURA: A PATIENT TREATED WITH CYCLOSPORIN ASpecial Feature: New Therapies for Aplastic Anemia 1 May 1985Volume 102, Issue 5Page: 720-720KeywordsAndrogensBone marrowBone marrow failureGlobulinsMegakaryocytesPathogenesis Issue Published: 1 May 1985 PDF downloadLoading ...