tbuckley/cabot-search huggingface dataset:
Abstract 1678: Visualization of thymidine kinase 1 on the surface of cancer cell lines: A potential diagnostic marker and therapeutic target
Authors: Robert A. Whitehurst, Dagoberto Estevez, Daniel W. Sharp, Melissa M. Alegre, Richard A. Robison, Kim L. O'Neill
Journal: Cancer Research (2011)

Abstract Thymidine Kinase 1(TK1) is a salvage pathway enzyme that has been shown to be elevated in many different cancer types, including breast, prostate, and colon. Previous research in our lab using plasma membrane separation has shown an increase in TK1 levels associated with the plasma membrane of cancer cells when compared to normal lymphocytes. After membrane separation the plasma membrane of normal lymphocytes showed a TK1 activity of 1,012 CPM/mg protein/hr(N=20) whereas those of cancer cells showed: Jurkat 34,096(N=28), Raji 70,195(N=20), HL60 46,217(N=34), and MDA-MB-435 50,359(N=24). In this study we sought to further investigate this association by visualizing the surface staining of fluorescently tagged antibodies to TK1. Using a primary rabbit anti-TK1 antibody and a secondary goat anti-rabbit antibody conjugated with a FITC fluorochrome we were able to stain the cells and identify TK1 bound to the cell surface. Using a fluorescent microscope we were able to visualize the fluorescent staining of TK1 in various cancer cell lines, including: Raji, Jurkat, HL60, MDA-MB-435, H358, and MCF-7. We compared these results to our control of stained normal lymphocytes, which showed significantly greater levels of staining in cancer cells. Our results further confirm the presence of membrane associated TK1, and provide further evidence of TK1's usefulness as a diagnostic marker and potential therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1678. doi:10.1158/1538-7445.AM2011-1678
Widening Rural-Urban Disparities in Youth Suicides, United States, 1996-2010
Authors: Cynthia A. Fontanella, Danielle L. Hiance-Steelesmith, Gary S. Phillips, Jeffrey A. Bridge, Natalie Lester, Helen Anne Sweeney, John V. Campo
Journal: JAMA Pediatrics (2015)

Little is known about recent trends in rural-urban disparities in youth suicide, particularly sex- and method-specific changes. Documenting the extent of these disparities is critical for the development of policies and programs aimed at eliminating geographic disparities.To examine trends in US suicide mortality for adolescents and young adults across the rural-urban continuum.Longitudinal trends in suicide rates by rural and urban areas between January 1, 1996, and December 31, 2010, were analyzed using county-level national mortality data linked to a rural-urban continuum measure that classified all 3141 counties in the United States into distinct groups based on population size and adjacency to metropolitan areas. The population included all suicide decedents aged 10 to 24 years.Rates of suicide per 100,000 persons.Across the study period, 66,595 youths died by suicide, and rural suicide rates were nearly double those of urban areas for both males (19.93 and 10.31 per 100,000, respectively) and females (4.40 and 2.39 per 100,000, respectively). Even after controlling for a wide array of county-level variables, rural-urban suicide differentials increased over time for males, suggesting widening rural-urban disparities (1996-1998: adjusted incidence rate ratio [IRR], 0.98; 2008-2010: adjusted IRR, 1.19; difference in IRR, P = .02). Firearm suicide rates declined, and the rates of hanging/suffocation for both males and females increased. However, the rates of suicide by firearm (males: 1996-1998, 2.05; and 2008-2010: 2.69 times higher) and hanging/suffocation (males: 1996-1998, 1.24; and 2008-2010: 1.63 times higher) were disproportionately higher in rural areas, and rural-urban differences increased over time (P = .002 for males; P = .06 for females).Suicide rates for adolescents and young adults are higher in rural than in urban communities regardless of the method used, and rural-urban disparities appear to be increasing over time. Further research should carefully explore the mechanisms whereby rural residence might increase suicide risk in youth and consider suicide-prevention efforts specific to rural settings.
Obesity, Behavioral Lifestyle Factors, and Risk of Acute Coronary Events
Authors: Majken K. Jensen, Stephanie E. Chiuve, Eric B. Rimm, Claus Dethlefsen, Anne Tjønneland, Albert M. Joensen, Kim Overvad
Journal: Circulation (2008)

Background— Whether physical activity reduces the impact of obesity on the risk of acute coronary events is much debated. However, little is known about the role of other potentially modifiable lifestyle factors in combination with obesity. Methods and Results— We followed up 54 783 women and men from the prospective Danish Diet, Cancer and Health study who were 50 to 64 years at baseline (1993 to 1997) and free of coronary artery disease and cancer. During a median of 7.7 years, 1127 incident cases of acute coronary syndrome (ACS) occurred. After multivariable adjustments, each unit of body mass index was associated with a 5% and 7% higher risk of ACS among women and men, respectively (both P &lt;0.0001 for trend). Overweight (body mass index, 25 to 29.9 kg/m 2 ) and obesity (body mass index ≥30 kg/m 2 ) were associated with a higher risk of ACS among the physically active and inactive, in nonsmokers and smokers, and among those who adhered more or less to a heart-healthy dietary pattern. Obese individuals who were active 1 to 3.5 h/wk had a lower risk than sedentary, obese individuals. In addition, obese nonsmokers had a lower risk than obese smokers. Adherence to a healthy diet was associated with a lower risk of ACS; however, the relative risk was not different among obese individuals with the most healthy diet versus obese individuals with a less healthy diet. Conclusions— Obesity confers an elevated risk of ACS in both healthy and less healthy subgroups of lifestyle behaviors. Adherence to healthy lifestyle behaviors was associated with a lower risk even among obese individuals.
MISTAKEN DIAGNOSES IN INFANTS AND CHILDREN
Authors: LOUIS C. SCHROEDER
Journal: JAMA (1924)

The opportunity to check clinical diagnoses with necropsy findings is available to all hospitals with an active pathologic service. Reports, however, are infrequent, and the analysis here presented, from the New York Nursery and Child's Hospital, covering a period of three years, is presented with the hope that it will lead to similar studies. Cabot's<sup>1</sup>contribution is well known, and any one intending to pursue such studies will do well to heed his admonitions. He says in part: It is not a simple matter to collate antemortem and postmortem data in an intelligent way. One cannot simply read off the clinical diagnoses and note their correspondence or lack of it with the anatomic findings, for: It is often obvious when one reads the clinical record that the diagnosis has been copied from the autopsy protocol. The clinical diagnosis may be so abbreviated as to omit important facts known during
Immediate effect of expiratory loading on left ventricular stroke volume.
Authors: T K Natarajan, R A Wise, M Karam, S Permutt, H N Wagner
Journal: Circulation (1987)

While the steady-state effects of positive pleural pressure on the circulation have been extensively studied, less is known about the immediate effects of positive intrathoracic pressure on cardiac dynamics. Therefore, we performed electrocardiographically gated radionuclide ventriculography with a respiratory gating technique in nine healthy subjects during quiet breathing and during expiration against a 24 cm H2O expiratory threshold load. During expiration, respiratory loading caused an increase in stroke counts by 29.4% (p less than .001) due to an increase in end-diastolic counts of 26.1% (p less than .001). End-systolic counts also rose 18.8% (p less than .05). The ejection fraction did not change significantly. These findings indicate that the increase in left ventricular stroke volume that occurs during the first 1 or 2 beats of a loaded expiration is due to an increase in left ventricular filling and not to augmentation of left ventricular ejection. This immediate increase in pulmonary venous return may reflect increased distensibility of the left ventricle due to decreased filling of the right ventricle.
Grass pollen immunotherapy: Symptomatic improvement correlates with reductions in eosinophils and IL-5 mRNA expression in the nasal mucosa during the pollen season
Authors: Duncan R. Wilson, Kayhan T. Nouri-Aria, Samantha M. Walker, Giovanni B. Pajno, Fiona O’Brien, Mikila R. Jacobson, Ian S. Mackay, Stephen R. Durham
Journal: Journal of Allergy and Clinical Immunology (2001)
Deafness to Digital Watches
Authors: James F. Burris
Journal: JAMA (1984)

To the Editor.—  Holding a ticking watch near the patient's ear is a time-honored hearing test. The new silent digital watches now threaten to deprive us of this familiar but imprecise tool. Many of them include a feature, however, that can alert physicians to a patient's early hearing loss, as illustrated by the following case.  Report of a Case.—  A healthy, alert 71-year-old man received a digital watch with a programmable alarm as a gift. A few days later, he mentioned that he was planning to return the watch because he could not make it function properly—the alarm would not sound. His physician son-in-law then tested the watch, found it functioned correctly, and held it in front of the older man to demonstrate the alarm. Both were surprised when the high-pitched beeping tone of the alarm proved inaudible to the older man. Audiometric testing subsequently confirmed a significant hearing loss
Effects of damp and mould in the home on respiratory health: a review of the literature
Authors: J. K. Peat, J. Dickerson, J. Li
Journal: Allergy (1998)

This review examines whether there is a direct or indirect relation between damp or mould in the home and respiratory health. Home dampness is thought to have health consequences because it has the potential to increase the proliferation of house‐dust mites and moulds, both of which are allergenic. The results from the many studies conducted to investigate whether damp and mould are associated with health outcomes are diffecult to compare because the methods of measuring exposures and helth outcomes have not been standardized. However, the studies that have been conducted in children are probably the most reliable because the confounding effects of active smoking or occupational exposures are absent, and because the presence of symptoms of cough and wheeze have been consistently investigated in many studies. The increased risk of children having these symptoms if the home has damp or mould is fairly small with an odds ratio that is generally in the range 1.5–3.5, these estimates being statistically significant when the sample size has been large enough. This range is consistent with the measured effects of other environmental exposures which are considered important to helth, such as environmental tobacco smoke or outdoor air pollutants. The potential benefits or reducing mould in the home have not been investigated, and the few studies that have investigated health improvement as a result of increasing ventilation or reducing damp in order to reduce house‐dust mite levels suggest that this intervention is expensive, requires a large commitment, and is unlikely to be successful in the long term. This implies that houses need to be specifically designed for primary prevention of respiratory problems associated with indoor allergen proliferation rather than using post hoc procedures to improve indoor climate and reduce allergen load as a secondary or tertiary preventive strategy.
Surgeons perform transatlantic operation using fibreoptics
Authors: Scott Gottlieb
Journal: BMJ (2001)

Surgeons working in New York have successfully used remotely controlled robots to laparoscopically remove a gall bladder from a 68 year old woman in Strasbourg, France. This is the world's first transoceanic operation on humans that has been conducted over high speed fibreoptic connections (Nature 2001;413:379-80).

Although robotic surgery is now commonplace in at least 100 hospitals around the world, the successful operation proves the feasibility of using robots to perform operations remotely over long distances. …
PREPAYMENT PLANS FOR HOSPITAL CARE
Authors: R. G. LELAND
Journal: JAMA (1933)

Although it is claimed that the temples of Saturn represent the origin of hospitals, thousands of years passed after this alleged classical beginning before civilization had developed to an appreciation of and a demand for buildings set apart exclusively for the care of the sick, even in the largest urban centers. Hospitals of the early centuries of the Christian era were established for various purposes—the housing and relief of orphaned children, the aged, the poor, the infirm, the lame and the blind, and for lepers outside the towns. These were charitable, relief and service institutions and no doubt contributed much to the comfort of the unfortunates who applied for succor. It is not definitely known, in each instance, to what degree medical care and nursing constituted the functions of these early hospitals but it should be clear that the expansion of this phase of hospital service was directly dependent on
Laboratory Testing for Lyme Neuroborreliosis—Reply
Authors: Michael T. Melia, Paul M. Lantos, Paul G. Auwaerter
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Normativism versus mechanism
Authors: Valerie A. Thompson
Journal: Behavioral and Brain Sciences (2011)

Abstract Using normative correctness as a diagnostic tool reduces the outcome of complex cognitive functions to a binary classification (normative or non-normative). It also focuses attention on outcomes, rather than processes, impeding the development of good cognitive theories. Given that both normative and non-normative responses may be produced by the same process, normativity is a poor indicator of underlying processes.
Imatinib for the Treatment of Pulmonary Arterial Hypertension
Authors: Hossein A. Ghofrani, Werner Seeger, Friedrich Grimminger
Journal: New England Journal of Medicine (2005)

To the Editor: We report on a 61-year-old man with a rapidly progressing form of familial idiopathic pulmonary arterial hypertension. Five years earlier, the patient had presented with signs of right-sided heart failure in our pulmonary-hypertension referral center. During the previous year, his condition had progressively deteriorated, despite advanced combination therapy with oral bosentan (125 mg twice daily),1 inhaled iloprost (nine inhalations per day),2 and oral sildenafil (50 mg three times a day).3,4 The patient's six-minute walking distance had progressively declined during the previous nine months, from 323 m to 260 m, and the pulmonary vascular resistance increased from . . .
MILK AND MOLASSES ENEMA
Authors: Levi W. Halsey
Journal: JAMA (1933)

To the Editor:  —InThe Journal, recently, inquiries were made regarding the possible origin of the use of the milk and molasses enema. One of these letters states that Dr. Senn over forty years ago found in his investigations that it was in common use in India and possibly its first employment originated there.  My own professional work dates to early 1883. The three previous years, while a student, I had the privilege of riding with my grandfather, a physician of wide experience, over a large country field. I found him at that time using this formula frequently and I recall his stating to me that it was an old and valuable therapeutic measure.  I have no knowledge of it beyond this. He was educated in the Yale University Medical School, graduating about 1834. Something like twenty years ago two surgeons in the Mountainside Hospital began using the milk and
More on pneumonia: Clinical judgment is also needed with CURB score
Authors: Kirsty Challen, Darren Walter, John Bright, Andrew Bentley
Journal: BMJ (2006)

EDITOR—Commendably, Owen et al are committed to reducing inappropriate intravenous antibiotic prescribing but we are concerned by some of their assumptions.1 Although the guidelines from the British Thoracic Society state that patients with a CURB-65 score of 0 …
Suppression of Lymphocyte Stimulation Following Bereavement
Authors: Steven J. Schleifer
Journal: JAMA (1983)

In a prospective study of 15 spouses of women with advanced breast carcinoma, lymphocyte stimulation responses to phytohemagglutinin, concanavalin A, and pokeweed mitogen were significantly suppressed during the first two months following the death of a spouse compared with prebereavement levels. A highly significant suppression was seen as early as one month after bereavement. No differences were found in total lymphocyte or B- or T-cell numbers. An intermediate level of mitogen responsivity was found during the four- to 14-month period after bereavement. Suppressed immunity following the death of a spouse may be related to the increased morbidity and mortality associated with bereavement. (<i>JAMA</i>1983;250:374-377)
Mechanism of beneficial effect of beta-adrenergic blockade on exercise-induced myocardial ischemia in conscious dogs.
Authors: B D Guth, G Heusch, R Seitelberger, J Ross
Journal: Circulation Research (1987)

We examined the importance of decreased heart rate in the beneficial effect of beta-adrenergic blockade on exercise-induced regional myocardial ischemia and contractile dysfunction in conscious dogs with single vessel coronary stenosis (ameroid constrictor). Studies were performed during control treadmill exercise, which produced regional myocardial ischemia (blood flow measured with microspheres) and wall dysfunction (measured using sonomicrometers). A second run was performed after the administration of atenolol (0.3-1.0 mg/kg i.v.), and the reduced heart rate caused by atenolol during early steady-state running was then prevented by atrial pacing during the latter portion of the run. Atenolol reduced the exercise heart rate from 217 +/- 25 beats per minute (SD, n = 9) to 166 +/- 15, and ischemic zone wall thickening during systole improved from 27 +/- 22% of the resting value in the control run to 50 +/- 25% of the resting value in the atenolol run (p less than 0.01). Atrial pacing then increased heart rate to 217 +/- 23 beats per minute, and regional wall thickening deteriorated to 15 +/- 25% of the resting value. Regional subendocardial blood flow in the ischemic zone during atrial pacing with atenolol was slightly less than that observed in the control run, in both ischemic and control zones, indicating no remaining beneficial effect of atenolol when heart rate reduction was eliminated. We conclude that the only significant mechanism for the improvement in exercise-induced ischemia and wall motion produced by atenolol is a reduction in the exercise heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)
Distributing US Health Aid
Authors: Kenneth Hugh Mayer
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TABLE WINES. ARE THEIR USES TO BE ENCOURAGED?
Authors: HENRY O. MARCY
Journal: JAMA (1904)

I suppose the preacher of even a lay sermon is expected to select some text more or less befitting the subject of his discourse; therefore, I have chosen I Timothy v, 23, "Drink no longer water, but use a little wine for thy stomach's sake and thine often infirmities." In these days of biblical exogesis the reverential respect of the fathers has become badly shaken, and with perfect complacency we now revise the revision of the revised word until, like the boy's jackknife, the new handle, fitted to the new blade, is still claimed to be the same old knife. The first revision was in the earlier day, when the crusaders of the new temperance faith openly absolved allegiance to King Alcohol, and declared that public tippling at the house of the tapster should be abolished.' The temperance lecturers dwelt on the evils and the doom of these open enlisted
A Comparison of Nonionic, Low-Osmolality Radiocontrast Agents with Ionic, High-Osmolality Agents during Cardiac Catheterization
Authors: Brendan J. Barrett, Patrick S. Parfrey, Hilary M. Vavasour, Frank O'Dea, Gloria Kent, Eric Stone
Journal: New England Journal of Medicine (1992)

Nonionic, low-osmolality radiocontrast agents are used frequently because they are believed to be safer than ionic, high-osmolality agents, but they are also more expensive. We conducted a randomized trial to compare the incidence of adverse events after the administration of ionic, high-osmolality and of nonionic, low-osmolality radiocontrast agents during cardiac angiography.
Relationship of S100A9 (S100 Calcium binding Protein A9) with Neutophilic Inflammation in Murine Asthma Model
Authors: Jong-Sook Park, Tae-Hyeong Lee, Hye-Rim Shin, Hyun Ji Song, Jeong-Dong Kim, Choon-Sik Park
Journal: Journal of Allergy and Clinical Immunology (2015)