tbuckley/cabot-search huggingface dataset:
Phase II Study of Recombinant Human Interferon Gamma for Treatment of Cutaneous T-Cell Lymphoma
Authors: E. H. Kaplan, S. T. Rosen, D. B. Norris, H. H. Roenigk, S. R. Saks, P. A. Bunn
Journal: JNCI Journal of the National Cancer Institute (1990)

Recombinant human interferon gamma (rIFN-gamma) was used for the treatment of 16 patients with various stages of cutaneous T-cell lymphoma (CTCL). All patients had been previously treated with standard topical and/or systemic therapies, and some had received experimental treatment with retinoids, recombinant human interferon alfa-2a (rIFN-alpha 2a), or radiolabeled monoclonal antibodies; most patients had an advanced stage of disease. Objective partial responses (PRs) were noted in five patients (31%) and lasted 3 months to greater than 32 months (median, 10 mo). One of these five patients had previously had disease progression after an initial PR with rIFN-alpha 2a. Six other patients (38%) showed minor or mixed responses. The most common side effects of rIFN-gamma included fever, weight loss, mild neutropenia, elevated lactate dehydrogenase, and elevated hepatic transaminases. Additionally, one episode of nephrotic syndrome and one cutaneous allergic reaction were noted. None of the toxic effects were life threatening, and all were reversible. These results suggest that rIFN-gamma has efficacy in the treatment of CTCL refractory to rIFN-alpha 2a.
Gamma Globulin Therapy for Asthmatic Children-Reply
Authors: Bernard Redner
Journal: JAMA (1963)

I admit that the ramifications of our observations will require additional studies, some of which we are engaged in and some of which we hope our report has stimulated others to initiate. At this time, we cannot discuss the relative value of placenta-derived gamma globulin vs gamma globulin pooled from human blood. This will be the object of future investigation. We began treatment of our patients with placenta-derived gamma globulin and continued in the same fashion. Several of our colleagues have independently reported to us that they have better clinical results when administering placenta-derived gamma globulin in place of the other. We feel that most physicians who treat allergic children with "infectious" asthma, a recurrent, stubbornly tenacious disease, will welcome a new effective method to help relieve the suffering of asthmatic children.
Lumbar Disc Disease
Authors: Edward Tarlov
Journal: JAMA (1993)

The second edition of this authoritative volume on the ubiquitous problem of degenerative lumbar disk disease has been expanded and updated. The 31 chapters provide a variety of viewpoints, ranging from the solidly established to the controversial. In a number of areas it is not yet clear what advantages a new treatment offers, compared with the more established approaches. In this volume, one might criticize the relative lack of commentary by the editor himself on such controversial subjects, including posterior lumbar interbody fusion, indications for fusion, chymopapain, microdiskectomy, manipulation, thermography, various imaging techniques, and other areas. Although the initial chapter contains a few misleading statements, such as, "Most if not all cases of sciatica are caused by disc herniation or rupture," it nevertheless provides a very interesting historical perspective. The chapter on anatomy of the lumbar spine is informative and sound and that on the natural history and epidemiology of
Aortic valve incompetence and replacement in rheumatoid arthritis.
Authors: J M Iveson, U Thadani, M Ionescu, V Wright
Journal: Annals of the Rheumatic Diseases (1975)

Five cases of aortic incompetence and nodular seropositive rheumatoid arthritis are presented. Four cases underwent aortic valve replacement. Two of these had granulomatous involvement of the aortic cusps similar to subcutaneous rheumatoid nodules, and another showed a nonspecific fibrosis. One case had definite coincidental rheumatic aortic and mitral heart disease. Two patients had undergone pericardectomy previously for constrictive pericarditis. Good results were obtained in all four operated cases and cardiac surgery enabled continuation of rehabilitation for the rheumatoid arthritis, including major orthopaedic procedures. A review of 22 cases from the literature with rheumatoid granulomata within the aortic valve shows that they are associated with mitral valve granulomata in 63-6%. Congestive cardiac failure was found in 75%. Macroscopical evidence of aortic incompetence was seen in 36-8% and of aortic stenosis in 15-8%. Associated pericarditis occurred in 59-1%, which was severe or complicated in 13.6%. The associated arthritis was severe in 77-8% with subcutaneous nodules (71-5%), rheumatoid factor (83-6%), and episcleritis (66-6%). From these cases and a review of the literature the following points are emphasized. (1) Both the granulomatous and nonspecific aortic valvulitis of rheumatoid arthritis may result in significant haemodynamic abnormality. (2) The valve lesions found are often clinically and macroscopically indistinguishable from rheumatic valve lesions. (3) Granulomata, when present, are usually found in the valve cusp or ring and only occasionally in the aortic wall. (4) Associated joint disease, although usually severe, may be mild. (5) The valve lesion may be accompanied by a severe pericardial involvement--either tamponade or constriction. (6) Aortic valve replacement for aortic incompetence in rheumatoid arthritis is both feasible and worthwile, despite severe joint disease.
Review: Target-oriented drug treatment improves clinical outcomes more than routine care in rheumatoid arthritis
Authors: Roland Staud
Journal: Annals of Internal Medicine (2010)

ACP Journal Club21 September 2010Review: Target-oriented drug treatment improves clinical outcomes more than routine care in rheumatoid arthritisRoland Staud, MDRoland Staud, MDUniversity of Florida, Gainesville, Florida, USA (R.S.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-6-201009210-02009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSchoels M, Knevel R, Aletaha D, et al. Evidence for treating rheumatoid arthritis to target: results of a systematic literature search. Ann Rheum Dis. 2010;69:638-43. https://pubmed.ncbi.nlm.nih.gov/20237123Clinical Impact RatingsGIM/FP/GP: Rheumatology: References1 UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-53. [PMID: 9742976] Google Scholar2 Smolen JS, Aletaha D, Bijlsma JW, et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2010;69:631-7. [PMID: 20215140] Google Scholar3 Grigor C, Capell H, Stirling A, et al. Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet. 2004;364:263-9. [PMID: 15262104] Google Scholar4 Verstappen SM, Jacobs JW, van der Veen MJ, et al. Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial). Ann Rheum Dis. 2007;66:1443-9. [PMID: 17519278] Google Scholar5 van Tuyl LH, Lems WF, Voskuyl AE, et al. Tight control and intensified COBRA combination treatment in early rheumatoid arthritis: 90% remission in a pilot trial. Ann Rheum Dis. 2008;67:1574-7. [PMID: 18625629] Google Scholar Author, Article, and Disclosure InformationAuthors: Roland Staud, MDAffiliations: University of Florida, Gainesville, Florida, USA (R.S.)This article was published at Annals.org on 7 September 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 September 2010Volume 153, Issue 6Page: JC3-9KeywordsDrugsImmunologyQuality of lifeQuestionnairesResearch designRheumatoid arthritisRheumatologyStable coronary artery diseaseSystematic reviews ePublished: 21 September 2010 Issue Published: 21 September 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
FAMILIAL AUTONOMIC DYSFUNCTION
Authors: Conrad M. Riley
Journal: JAMA (1952)

Up to 1949 there had appeared several isolated case reports<sup>1</sup>of what now seem to be examples of a definite clinical entity. This is characterized by evidences of vegetative dysfunction, such as excessive perspiration, drooling, erythematous blotching of the skin, intermittent hypertension, and defective lacrimation; hyporeflexia and emotional instability are also present. In 1949 my co-workers and I reported five illustrative cases.<sup>2</sup> Since then our experience with the condition has grown with new cases and repeated observations on old cases. Other hospitals and physicians have made available the records of additional cases, so that we are nowable to present a more definitive picture of the condition, based on a total of 33 cases. Their sources are shown in table 1. <h3>CLINICAL FEATURES</h3> In table 2 the common features are listed and their frequency in this series shown. These are arranged in two groups, the first (group A)
Heavy Particles in Experimental Medicine and Therapy
Authors: John H. Lawrence
Journal: JAMA (1966)

Early studies in Berkeley, Calif, in 1935 showed that heavy particles (neutrons produced in one of the early cyclotrons) producing relatively dense tissue ionization (Fig 1) had a greater biological effect per unit dose on normal and neoplastic tissue than x-rays or gamma rays. This work led to the early trial of neutrons in the treatment of cancer; but because these low-energy heavy particles had disadvantages of great scatter, poor penetration, and poor localization, the results were disappointing. However, new accelerators were soon developed which were capable of providing heavier, charged particles with greater energies, and during the past 11 years these particles have been successfully used in the treatment of neoplastic, metabolic, and neurological diseases. <h3>Therapeutically Advantageous Characteristics</h3> High-energy, heavy, charged particles differ from x-rays and gamma rays with respect to interaction with tissue in two important ways. First, unlike electromagnetic radiations, they have little scatter and have a
ATP release after partial hepatectomy regulates liver regeneration in the rat
Authors: Emmanuel Gonzales, Boris Julien, Valérie Serrière-Lanneau, Alexandra Nicou, Isabelle Doignon, Laura Lagoudakis, Isabelle Garcin, Daniel Azoulay, Jean-Charles Duclos-Vallée, Denis Castaing, Didier Samuel, Andres Hernandez-Garcia, Samir S. Awad, Laurent Combettes, Sundararajah Thevananther, Thierry Tordjmann
Journal: Journal of Hepatology (2009)
Airspace Configuration at Different Transpulmonary Pressures in Normal and Paraquat-induced Lung Injury in Rats
Authors: MARJORIE F. R. SILVA, WALTER A. ZIN, PAULO H. N. SALDIVA
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

The aim of this study is to evaluate histoarchitecture of airspaces at different positive transpulmonary pressures, both during inflation and deflation of excised normal and paraquat-damaged rat lungs. Freshly excised lungs were placed in a plethysmograph connected to a graded pipette. Immediately after the achievement of the desired pressure level (5, 15, 25 cm H2O during inflation, and 15 and 5 cm H2O during deflation), the tracheal cannula was occluded and lungs were quick-frozen by immersion in liquid nitrogen, and fixed using Carnoy's solution. Sections representing the central and peripheral areas of the lungs were sampled and processed for paraffin embedding and stained with hematoxylin–eosin. By means of stereological techniques, surface-to-volume ratio (S/V) and the fraction of large-volume gas-exchanging airspaces (LVGEAS) were determined. We observed in paraquat-treated animals evidence of alveolar instability close to the resting volume. Structural unevenness was minimized by massive recruitment followed by alveolar pressurization. In conclusion, this work demonstrates that morphological evidence of uneven distribution of inspired air may be partially reversed by applying larger alveolar pressures. These larger pressures applied at the end-expiration in vivo (positive end-expiratory pressure, PEEP) can minimize the distortion of lung microarchitecture during ventilation.
T-zone lymphoma with cutaneous involvement: a case report and review of the literature
Authors: D.V. Kazakov, W. Kempf, S. Michaelis, U. Schmid, S. Cogliatti, R. Dummer, G. Burg
Journal: British Journal of Dermatology (2002)

Summary T‐zone lymphoma (TZL) is a rare subtype of nodal peripheral T‐cell lymphoma characterized by a clonal expansion of T‐zone lymphocytes accompanied by a proliferation of other T‐zone constituents. Non‐specific cutaneous alterations are seen in about one‐third of all cases, but specific cutaneous involvement is extremely rare. We present a case of TZL with secondary skin infiltration, review the literature on cutaneous manifestations of TZL and discuss the differential diagnosis of TZL.
Chemotherapy of Experimental Streptococcal Endocarditis. I. COMPARISON OF COMMONLY RECOMMENDED PROPHYLACTIC REGIMENS
Authors: David T. Durack, Robert G. Petersdorf
Journal: Journal of Clinical Investigation (1973)

The effectiveness of various antibiotics commonly recommended for the prophylaxis of bacterial endocarditis has been evaluated in experimental streptococcal endocarditis in rabbits. High doses of penicillin G did not prevent the development of this infection. The only consistently successful prophylactic regimens using penicillin alone were those which provided for both an early high serum level and more than 9 h of effective antimicrobial action. Vancomycin was the only other drug which proved uniformly successful when given alone, even though the duration of its antimicrobial action in the blood was only 3 h. However, combined therapy using penicillin G or ampicillin with streptomycin was always effective in prophylaxis. Treatment with single injections of ampicillin, cephaloridine, cephalexin, clindamycin, cotrimoxazole, rifampicin, streptomycin, erythromycin, and tetracycline failed to prevent infection.
Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes
Authors: G. Jego, D. Lanneau, A. de Thonel, K. Berthenet, A. Hazoumé, N. Droin, A. Hamman, F. Girodon, P.-S. Bellaye, G. Wettstein, A. Jacquel, L. Duplomb, A. Le Mouël, C. Papanayotou, E. Christian, P. Bonniaud, V. Lallemand-Mezger, E. Solary, C. Garrido
Journal: Leukemia (2014)
Sir George Smart
Authors: C. Richmond
Journal: BMJ (2004)

George Smart was a physician who specialised in metabolic medicine, nutrition, and endocrinology, but it is for his contribution to medical education that he will best be remembered. The curriculum he introduced at Newcastle and later copied by other medical schools did away with much rote learning and was based on problem solving and the needs of patients. He also improved continuing medical education at the Royal College of Physicians and became an energetic and popular director of the British Postgraduate Medical Federation.

After qualifying at Newcastle Medical School, which was then part of Durham University, taking a BSc in physiology en route, he did his house jobs …
TENTH INTERNATIONAL MEDICAL CONGRESS.
Authors: Ephraim Cutter
Journal: JAMA (1890)

<h3>To the Editor:</h3> —I have the honor to report something more than the fact of a pleasurable time— and the meeting with many eminent men. What I saw and heard by no means embraced the whole scope of the Congress. No one person could take this in, and as its full relation would overcrowd the columns ofThe Journal, only a few items will be referred to. <h3>1. The Management.</h3> —The Congress was well managed, if a great good-natured medical assemblage can be well managed anywhere. Everywhere was present the evidence that almost everything of advantage to its members had been anticipated with that thoroughness of detail which characterizes German methods. It was a fine idea that of holding the sessions in Exhibition Park, a large enclosed area of many acres, amply furnished with space outside and inside. The arches of an elevated railroad that ran through it were utilized
Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery
Authors: Makoto Oba, Kanjiro Miyata, Kensuke Osada, R. James Christie, Mai Sanjoh, Weidong Li, Shigeto Fukushima, Takehiko Ishii, Mitsunobu R. Kano, Nobuhiro Nishiyama, Hiroyuki Koyama, Kazunori Kataoka
Journal: Biomaterials (2010)
Experiences with a rat bio-assay in the diagnosis of the Zollinger-Ellison syndrome
Authors: C. G. Thomson, I. G. M. Cleator, W. Sircus
Journal: Gut (1970)

Reported here are the assay results, using the anaesthetized rat preparation of Lai (1964), of plasma from patients known or suspected to have peptide-secreting adenomata and these are compared with assays carried out on plasma from patients whose clinical history excluded such pathology. It is suggested that these demonstrate that this technique is of diagnostic value in this condition and that it has practical advantages over other bio-assay methods currently available and physiological advantages over immunological methods. It may well be that identification of the presence of tumour in these patients may first be made by immunological techniques to be followed by functional identification using a bioassay procedure such as is described here.
1122 Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy for metastatic colorectal cancer
Authors: L RUBBIABRANDT, V AUDARD, P SARTORETTI, A ROTH, C BREZAULT, M LECHARPENTIER, B DOUSSET, P MOREL, O SOUBRANE, S CHAUSSADE
Journal: Hepatology (2003)
Pannexin-1 hemichannel–mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse
Authors: Tobias Woehrle, Linda Yip, Abdallah Elkhal, Yuka Sumi, Yu Chen, Yongli Yao, Paul A. Insel, Wolfgang G. Junger
Journal: Blood (2010)
ANLN Plays a Critical Role in Human Lung Carcinogenesis through the Activation of RHOA and by Involvement in the Phosphoinositide 3-Kinase/AKT Pathway
Authors: Chie Suzuki, Yataro Daigo, Nobuhisa Ishikawa, Tatsuya Kato, Satoshi Hayama, Tomoo Ito, Eiju Tsuchiya, Yusuke Nakamura
Journal: Cancer Research (2005)

Abstract Gene expression profile analysis of non–small cell lung cancers (NSCLC) and subsequent functional analyses revealed that human ANLN, a homologue of anillin, an actin-binding protein in Drosophila, was transactivated in lung cancer cells and seemed to play a significant role in pulmonary carcinogenesis. Induction of small interfering RNAs against ANLN in NSCLC cells suppressed its expression and resulted in growth suppression; moreover, treatment with small interfering RNA yielded cells with larger morphology and multiple nuclei, which subsequently died. On the other hand, induction of exogenous expression of ANLN enhanced the migrating ability of mammalian cells by interacting with RHOA, a small guanosine triphosphatase, and inducing actin stress fibers. Interestingly, inhibition of phosphoinositide 3-kinase/AKT activity in NSCLC cells decreased the stability of ANLN and caused a reduction of the nuclear ANLN level. Immunohistochemical staining of nuclear ANLN on lung cancer tissue microarrays was associated with the poor survival of NSCLC patients, indicating that this molecule might serve as a prognostic indicator. Our data imply that up-regulation of ANLN is a common feature of the carcinogenetic process in lung tissue, and suggests that selective suppression of ANLN could be a promising approach for developing a new strategy to treat lung cancers. (Cancer Res 2005; 65(24): 11314-25)
Abstract 3055: Drug Eluting Stents and Delayed Arterial Healing: Paclitaxel Eluting Stents are associated with Increased Arterial Wall Inflammatory Changes when compared to Sirolimus Eluting Stents in a Porcine Restenosis Model
Authors: Marlos R Fernandes, Guilherme V Silva, Edie Oliveira, Franca Angeli, Ricardo Sanz, Pilar Jimenez-Quevedo, Joao A Assad, Rodrigo Branco, Javier Lopez, Fred Clubb, William Vaughn, Dipsu D Patel, Fred Baimbridge, Robert Falotico, Emerson C Perin
Journal: Circulation (2006)

Background: Questions still remain regarding differences in DES platforms. The present study compared the arterial healing and inflammatory response after the implant of sirolimus eluted stents (SE...
Do enforced bicycle helmet laws improve public health?: Start with an assessment of the base problem, rather than assume a solution
Authors: Peter J Clinch
Journal: BMJ (2006)

EDITOR—In a subject as polarised as the efficacy of cycle helmet research it is hardly surprising that Robinson's work disagrees with a considerable body of the evidence and that the same can be said of pieces suggesting helmet use is highly beneficial.1 2

Much controversy still exists about the effectiveness of cycle helmets, and it shows no sign of abating. This uncertain state of affairs is not a reasonable basis for …
Systemic delivery of BH4 anti-apoptotic peptide using CPPs prevents cardiac ischemia–reperfusion injuries in vivo
Authors: Prisca Boisguerin, Christelle Redt-Clouet, Alicia Franck-Miclo, Sana Licheheb, Joël Nargeot, Stéphanie Barrère-Lemaire, Bernard Lebleu
Journal: Journal of Controlled Release (2011)
Teriparatide for Bone Loss in the Jaw
Authors: Andrew Grey
Journal: New England Journal of Medicine (2010)

Teriparatide, which consists of the N-terminal 34 amino acids of parathyroid hormone, has been in clinical use for the treatment of osteoporosis for almost a decade, ever since clinical trials showed that among patients with severe osteoporosis who were treated with teriparatide, the relative risks of vertebral and nonvertebral fractures were reduced by 65% and 53%, respectively.1 Currently, treatment with teriparatide is limited to 2 years because of evidence from a preclinical study that the risk of osteosarcoma might be increased during long-term exposure.2 Unlike bisphosphonates, the current first-line agents for the prevention of fractures, which act primarily by inhibiting . . .