tbuckley/cabot-search huggingface dataset:
Maintenance of Certification
Authors: Donald Trainor
Journal: Annals of Internal Medicine (2015)

Letters6 January 2015Maintenance of CertificationDonald Trainor, MDDonald Trainor, MDFrom HealthNet, Inc., Indianapolis, Indiana.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5040-3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Centor and colleagues' editorial (1) made me think that, as a generalist medicine–pediatrics physician board certified by the American Board of Pediatrics (ABP) and the ABIM for more than 20 years with time-limited certification for both, I have always found the ABP MOC examinations to be much more primary care–focused than the initial or subsequent MOC ABIM general internal medicine examinations. In fact, it was particularly galling for me as someone who practices primary care to have had a faculty cardiology lecturer at an ACP-sponsored internal medicine MOC preparation course 3 years ago say that we needed ...Reference1. Centor RM, Fleming DA, Moyer DV. Maintenance of certification: beauty is in the eyes of the beholder [Editorial]. Ann Intern Med. 2014;161:226-7. [PMID: 24821483] doi:10.7326/M14-1014 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From HealthNet, Inc., Indianapolis, Indiana.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest Forms.do?msNum=L14-0500. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMaintenance of Certification: Beauty Is in the Eyes of the Beholder Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification: Beauty Is in the Eyes of the Beholder Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification Michael Kelley Maintenance of Certification Edward Ringel Maintenance of Certification Robert B. Copeland Maintenance of Certification Leonard Johnson Maintenance of Certification Antoinette Spevetz Maintenance of Certification Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification Michael Kelley Maintenance of Certification Leonard Johnson Maintenance of Certification Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification Antoinette Spevetz Maintenance of Certification Robert B. Copeland Maintenance of Certification Edward Ringel Metrics 6 January 2015Volume 162, Issue 1Page: 77-78KeywordsComputersConflicts of interestDisclosureMedical staffMedicareObstetrics and gynecologyPediatrics ePublished: 6 January 2015 Issue Published: 6 January 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Vancomycin MIC creep in MRSA isolates from 1997 to 2008 in a healthcare region in Hong Kong
Authors: Pak-Leung Ho, Pui-Ying Lo, Kin-Hung Chow, Eric H.Y. Lau, Eileen L. Lai, Vincent C.C. Cheng, Richard Y. Kao
Journal: Journal of Infection (2009)
164 INTRAPERITONEAL TRANSPLANTATION OF HEPATOCYTES EMBEDDED IN THERMOREVERSIBLE GELATION POLYMER (MEBIOL GEL) IN ACUTE LIVER FAILURE RAT MODEL
Authors: N. Parveen, A.A. Khan, S. Baskar, M.A. Habeeb, P. Ravindra Babu, A. Samuel, Y. Hiroshi, M. Yuichi, C.M. Habibullah
Journal: Journal of Hepatology (2008)
Aspiration or Exploration to Confirm Diagnoses of Renal Masses
Authors: Charles J. Devine
Journal: JAMA (1968)

Though some renal cysts require surgical treatment, recent improvements in diagnostic methods for differentiation of benign cysts from solid tumors have made it unnecessary to assume the risk associated with exploration of the kidney each time a mass is discovered. There remains, however, a percentage of error in the evaluation of these studies. Confirmation of the diagnosis should be obtained by aspiration in the case of cysts and by surgical exploration and treatment of tumors. We have employed a system for the evaluation of renal masses with the use of various radiological techniques. Whenever in the course of this investigation a diagnosis of cyst or tumor was made, the appropriate confirmatory procedure was carried out. If the diagnosis was still indefinite when all the tests had been done, exploration was also indicated.
Expression of Human Endogenous Retrovirus K in Melanomas and Melanoma Cell Lines
Authors: Kristina Büscher, Uwe Trefzer, Maja Hofmann, Wolfram Sterry, Reinhard Kurth, Joachim Denner
Journal: Cancer Research (2005)

Abstract The human endogenous retrovirus K family (HERV-K) comprises 30 to 50 closely related proviruses, most of which are defective. In contrast to all other human endogenous retroviruses, some HERV-K proviruses have maintained open reading frames for all viral proteins. In addition to the structural proteins Gag and Env and the reverse transcriptase, two regulatory proteins (Rec and Np9) have been described. Malignant melanoma has the highest mortality among skin cancers and is particularly aggressive. To study the expression of HERV-K, a set of seven primers was developed that allows discrimination between full-length and spliced mRNA and mRNA from deleted and undeleted proviruses. Expression of full-length mRNA from deleted and undeleted proviruses was detected in all human cells investigated. Expression of spliced env and rec was detected in a teratocarcinoma cell line, in 45% of the metastatic melanoma biopsies, and in 44% of the melanoma cell lines. In normal neonatal melanocytes, spliced rec was detected but not spliced env. Viral proteins were shown to be expressed in primary melanomas, metastases, and melanoma cell lines by immunohistochemistry, immunofluorescence, and Western blot analyses using specific antisera. For the first time, antibodies against HERV-K were found in melanoma patients. Melanomas are, in addition to teratocarcinomas and human breast cancer, the third tumor type with enhanced expression of HERV-K.
Toxic epidermal necrolysis in a premature infant of 27 weeks' gestational age
Authors: K. Lohmeier, M. Megahed, K.W. Schulte, H. Stannigel, E. Mayatepek, H. Schroten
Journal: British Journal of Dermatology (2005)

Toxic epidermal necrolysis (TEN) is very rare in the newborn period. So far, three cases of TEN in newborns have been reported worldwide. We report a premature infant of 27 weeks' gestational age with TEN at 4 weeks of age. Sepsis treated by an antibiotic combination regimen preceding the TEN was a common feature of all four cases. In our patient, coagulase-negative staphylococci could be identified by blood culture, whereas the previously reported patients suffered from Klebsiella pneumoniae sepsis or Escherichia coli sepsis. Possibly, the uniform association with septic infection in the cases of TEN in the neonatal period might hint at a causal association, thus differentiating it from TEN in older children or adults.
A Lecture on Yellow Fever. With a Description of the Bacillus Icteroides: Delivered before the University of Montevideo on June 10th, 1897
Authors: G. Sanarelli
Journal: BMJ (1897)

THE MICROBE OF YELLOW FEVER.[ 6XD'-Jo= 7_work in a responsible position, and able to acquit herself well.Of the other three, one, in which only a middle lobe or en- larged isthmus was removed, has improved very slowly, and only does housework at home.The other two are young ladies; one, the younger and more delicate type, is quite pleased with herself, but is evidently far from well yet; the older and stronger lady is certainly very much improved, and considers that she has regained her old health.I think this is putting matters at their best; and, although it is not quite as definite and satisfactory as one would like, it is sufficient to encourage me to continue the operation in all suitable cases.In adenoma the success is all one could wish, and I believe one might almost say the same in regard to parenchy- matous goitre; but in Graves's disease the circumstances are different, and I should be sorry if, by painting the results in too glowing colours, I encouraged anything like reckless operating in so serious a condition.6NOTES.'These have since been doubled. 2It has not recurred.3Have since had reason to believe it to be very necessary. 4Just seen accidentally, looking very well, and says she is very well; so there may be some mistake in regard to the unsatisfactory report. 5Since writing this paper, I have had the misfortune to lose a case of parenchymatous goitre, which I will report later.The case was complicated by advanced idiopathic cirrhosis of the liver. 6Sine this was written the improvement has been very iiiarked in all the cases of Graves's disease.
Phylogeny, Ontogeny, and Brain-Damaged Children
Authors: Samuel E. Paul
Journal: JAMA (1968)

To the Editor:—  I note with interest that the AMA discredits the unwarranted growing use of the Doman-Delacato treatment for brain-damaged children (205, Aug 19, 1968, adv p10).  Doman and Delacato quote ontogeny recapitulates phylogeny as the basis of their theory. Applied to the development of reading and handedness, Doman and Delacato have things reversed.1   Phylogenetically, writing originated about 5,000 BC, but handedness developed during the Bronze age (1500 to 700 BC)  Ontologically, the ability to read, may come as late as 10 to 12 years of age but right-left orientation may be as late as 12 to 15 years of age.   Investigation of the tonic neck reflex for determination of cerebral dominance showed neither hemisphere dominant in 50% of the 500 children in the first three elementary grades1(total population done), and at the seventh-grade level 40% showed neither hemisphere dominant.  Controlled studies by Freeman
Points: Is peritoneal dialysis a good long term treatment?
Authors: G. R Cooper
Journal: BMJ (1985)

reiterated my comment' on the treatment of cysticercosis with metriphonate and by means of radioimmunotherapy.Some other advances should be mentioned.In addition to praziquantel2-4 the anthelmninthic flubendazole has recently been used in the management of neurocysticercosis, with apparent success.5 Injection of quinine sulphate in distilled water into subcutaneous cysticerci has also been reported to destroy the bladderworms, thus obviating the need for their surgical excision.6
Hypertrophic Pulmonary Osteoarthropathy Demonstrated on SPECT/CT
Authors: Robert R. Russo, Allen Lee, Robert Mansberg, Louise Emmett
Journal: Clinical Nuclear Medicine (2009)

A 51-year-old man with a known history of hepatic cirrhosis and a right lung mass presented with hemoptysis and widespread bone pain. Sputum cytology demonstrated atypical cells. A CT scan of the chest demonstrated a 3-cm spiculating mass in the right lower lobe, in addition to nodules in both upper lobes and lymphadenopathy within the mediastinum and both hila. Skeletal scintigraphy was performed to assess for metastatic bone disease, and demonstrated increased tracer uptake along the cortex of the distal femurs bilaterally. There was also low-grade cortical uptake in the mid femur and tibia bilaterally on planar imaging. SPECT/CT was able to improve the specificity of the planar scintigraphic findings, by confirming tracer uptake was localized to the periosteum as expected for hypertrophic pulmonary osteoarthropathy, thereby excluding the presence of skeletal metastases.
Azathioprine and Prednisone in Polymyositis
Authors: WARREN H. GULLEN
Journal: Annals of Internal Medicine (1980)

Letters1 July 1980Azathioprine and Prednisone in PolymyositisWARREN H. GULLEN, M.D.WARREN H. GULLEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-1-148 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent paper in your journal (1) illustrates a common error in the use of probability methods. The authors conclude, on the basis of a test group and a placebo control group of eight patients each, that "the findings clearly indicate that azothioprine does not afford any therapeutic advantage when used in addition to accepted prednisone dosages in the initial management of polymyositis." Presumably, this conclusion was reached because the probability value associated with the statistical test used was greater than the traditional (although not divinely prescribed) 5%.The main difficulty here is that no power values...Reference1. BUNCHWORTHINGTONCOMBSILSTRUPENGEL TJJDA. Azathioprine with prednisone for polymyositis: a controlled, clinical trial. Ann Intern Med. 1980;92:365-9. LinkGoogle Scholar1. BUNCHWORTHINGTONCOMBSILSTRUPENGEL TJJDA. Azathioprine with prednisone for polymyositis: a controlled, clinical trial. Ann Intern Med. 1980;92:365-9. LinkGoogle Scholar2. HUNTERUROWITZGORDONSMYTHEOGRYZLO TMDHM. Azathioprine in rheumatoid arthritis: a long-term followup study. Arthritis Rheum. 1975;18:15-20. CrossrefMedlineGoogle Scholar3. SMYTHBARTHOLOMEWMILLSSTEIGERWALDSTRONGRECART CBDJSS. Cyclophosphamide therapy for rheumatoid arthritis. Arch Intern Med. 1975;35:789-93. CrossrefGoogle Scholar4. UROWITZHUNTERBOOKMANGORDONSMYTHEOGRYZLO MTADHM. Azathioprine in rheumatoid arthritis: a double-blind study comparing full dose to half dose. J Rheumatol. 1974;1:274-81. Google Scholar5. . A controlled trial of cyclophosphamide in rheumatoid arthritis. N Engl J Med. 1970;283:883-9. CrossrefMedlineGoogle Scholar6. SOKOLOFFGOLDBERGPEARSON MLC. Treatment of corticosteroid-resistant polymyositis with methotrexate. Lancet. 1971;1:14-6. CrossrefMedlineGoogle Scholar7. METZGERBOHANGOLDBERGBLUESTONEPEARSON AALRC. Polymyositis and dermatomyositis: combined methotrexate and corticosteroid therapy. Ann Intern Med. 1974;81:182-9. LinkGoogle Scholar8. BENSONALDO MM. Azathioprine therapy in polymyositis. Arch Intern Med. 1973;132:547-51. CrossrefGoogle Scholar9. MINTZFRAGAVALLE GAL. Effect of immunosuppressive therapy in adult polymyositis. Arthritis Rheum. 1971;14:405. Abstract. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WARREN H. GULLEN, M.D.Affiliations: Medical College of Georgia Augusta, GA 30901 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1980Volume 93, Issue 1_Part_1Page: 148-149KeywordsPolymyositis ePublished: 1 December 2008 Issue Published: 1 July 1980 PDF downloadLoading ...
Antibiotics and respiratory illness in general practice: prescribing policy and work load.
Authors: J G Howie, K R Hutchison
Journal: BMJ (1978)

enough to detect small amounts of possibly abnormal serum ferritin derived from leukaemic cells.Isoelectric focusing techniques have shown characteristic isoferritin profiles for several normal tissues and immunological differences can also be shown using specific antisera.4If immunological differences between leukaemic and normal ferritins exist it may be possible to produce an antibody directed against leukaemic cell ferritin; assays using such an antibody might be expected to yield data of clinical relevance in acute leukaemia.
Ancients or moderns?
Authors: T. Dalrymple
Journal: BMJ (2009)

It is a melancholy reflection (but also a testimony to the fact of more recent progress) that the question of whether the ancients or moderns were best was a live one in the first half of the 18th century, with regard not only to literature, where progress is perhaps rather difficult to assess or measure, but also to medicine, where progress is rather less difficult to recognise.

Francis Clifton, who had an MD from Leiden and was physician to the Prince of Wales, wrote his book The State of Physick, Ancient and Modern, Briefly Consider’d: With a Plan for the Improvement of It in 1732. He had no …
THE PRODUCTION OF OSTEOGENIC SARCOMATA AND THE EFFECTS ON LYMPH NODES AND BONE MARROW OF INTRAVENOUS INJECTIONS OF RADIUM CHLORIDE AND MESOTHORIUM IN RABBITS
Authors: F. R. Sabin, C. A. Doan, C. E. Forkner
Journal: The Journal of Experimental Medicine (1932)

The observations in this work suggest that with certain doses of radioactive material, the fundamental damage in the lymphoid tissues is to the stem cell and that the damage is to the chromatin of the nuclei of these cells. The erythroid tissues are apparently less susceptible to radioactive material than the lymphoid tissues but an original anemia of secondary type from peripheral destruction may eventually be changed to one of primary type through decreased maturation of primitive cells in the marrow. The damage of lymph nodes and bone marrow leads to atrophy of these organs. The cells of the liver and thymus suffer nuclear damage of the same general character as is seen in the lymph nodes, and there is an atrophy of these organs. The storage of the radioactive material in the bones gave rise to osteogenic sarcomata in two out of seven rabbits surviving from 11 to 19 months. A repetition of the experiment has been undertaken with more intensive studies to test the validity of the findings.
The Effects of Repetitive Electric Cardiac Stimulation in Dogs With Normal Hearts, Complete Heart Block and Experimental Cardiac Arrest
Authors: T. E. STARZL, R. A. GAERTNER, ROSCOE C. WEBB
Journal: Circulation (1955)

Direct cardiac stimulation was conducted in the open chest. In normal animals, auricular stimulation at frequencies faster than the spontaneous rate caused little change in vascular pressures or cardiac output. Comparable ventricular stimulation in the same animals caused falls in cardiac output and blood pressure, with elevations in venous pressure. In contrast, ventricular stimulation in animals with complete heart block caused elevations in cardiac output and blood pressure, and declines in venous pressure. A study was also made of repetitive stimulation in experimental cardiac arrest. Occasionally pacemaking was of value in the resuscitation, but in most cases effective contractions could not be induced with stimulation.
Intracarotid Phenoxybenzamine for Cerebral Arterial Spasm
Authors: B. H. Cummins, H. B. Griffith
Journal: BMJ (1971)

Phenoxybenzamine was injected into the carotid artery of 23 patients after operations on their cerebral arterial aneurysms. Rapid improvement was seen in three cases with pronounced neurological disability. The other 20 were treated prophylactically in an attempt to prevent the onset of spasm. These results would appear to indicate that intracarotid phenoxybenzamine may be of value in the treatment of cerebral arterial spasm, provided that it is given before irreversible infarction of the brain has occurred. Until more is known about its action it would be best to give the drug only after operation.
Mitotic indices and oral contraceptives.
Authors: J Mills, N P Bishun
Journal: BMJ (1971)

To determine the effect of oral contraceptives on mitotic indices in the peripheral blood leucocyte cultures of mothers and their progeny 70 women who had previously taken various oral contraceptive preparations (Ovulen-21 Anovlar-21  Gynovlar-21 Norinyl-1 Conovid-E Lyndiol-1 and Minovlar-21) were studied.  Blood samples were collected at time of delivery from the mother and newborn and the percentage of mitoses was calculated from examination of 500 cells from each subject.  No significant difference was found between the mitotic indices in treated subjects and appropriate controls.  Providing the hormonal constituents of these pills are still effective after discontinuation of use for up to 60 months it is concluded that oral contraceptives have no appreciable adverse effect on the mitotic activity of peripheral blood  cells.
Implications for Bat Evolution from Two New Complete Mitochondrial Genomes
Authors: Yu-Hsin Lin, David Penny
Journal: Molecular Biology and Evolution (2001)

Mitochondrial genomes are useful in the quantitative analysis of vertebrate evolution. We report here the complete mitochondrial genomes for a megabat (the flying fox, Pteropus scapulatus) and a microbat (the New Zealand long-tailed bat, Chalinolobus tuberculatus). The evolutionary history of bats (chiroptera) has been uncertain, and even the monophyly of this group has been questioned. The new sequences allow five questions to be addressed: the position of bats within eutheria, whether bats are monophyletic, whether microbats are paraphyletic with respect to megabats, the approximate timing of the origin of bats, and whether some insectivores (e.g., moles) form a sister group with bats. In order to examine these questions, we analyzed two data sets (both separately and combined), one with 12 protein-coding regions and the other with RNA (combined ribosomal RNAs and tRNAs). The results are congruent, support bat monophyly, and place bats close to the cetferungulates (whales [cetaceans] plus ferungulates [carnivores, ungulates, and perissodactyls]). The position of bats in the eutherian tree is uncertain. The most common assumption from anatomical evidence has been that they group with primates, flying lemurs, and tree shrews, forming the Archonta (Szalay 1977; Novacek 1992). However, in a phylogenetic analysis of the complete mitochondrial genome of the Jamaican fruit bat (Artibus jamaicensis; Pumo et al. 1998) it appeared more closely related to cetferungulates, a clade including Cetacea, Artiodactyla, Perissodactyla, and Carnivora. Phylogenetic analysis from the c-myc gene sequences also support this relationship (Miyamoto, Porter, and Goodman 2000). The recent publication of the mitochondrial genome of the mole (Talpa europaea; Mouchaty et al. 2000) placed this insectivore close to the Jamaican fruit bat. The sister position of the mole and the Jamaican fruit bat can be further tested by the addition of our two new bat mitochondrial genomes. Even the relationship between microbats and megabats is uncertain. On the basis of neuroanatomy, it has been suggested that megabats are more closely related to primates than to microbats (Pettigrew 1986; Pettigrew et al. 1989). This would imply a diphyletic origin for bats, a hypothesis which has not been supported by sequence data (Bennett et al. 1988; Mindell, Dick, and Baker 1991; Van Den Bussche et al. 1998) and can now be tested with much longer sequences, such as complete mitochondrial genomes. In contrast to the hypothesis of
Bone Marrow–Derived Cells for Enhancing Collateral Development
Authors: Tim Kinnaird, Eugenio Stabile, Mary Susan Burnett, Stephen E. Epstein
Journal: Circulation Research (2004)

Initial animal studies of single angiogenic agents, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), generated enthusiasm for the concept that these agents might enhance collateral development and thereby provide alternative therapies for patients with vascular disease not amenable to traditional revascularization. The enthusiasm, apparently justified by the subsequent results of small nonrandomized phase-I clinical trials, was then tempered by the subsequent disappointing results of randomized clinical trials. In light of these disappointing results, investigators have pursued alternative strategies in an attempt to improve tissue perfusion. One such strategy is the utilization of bone marrow-derived cell therapy. This review discusses mechanistic pathways mediating the effects of such cell therapy, summarizes the animal and early clinical experience, and speculates on the potential of genetic manipulation of bone marrow-derived cells in an attempt to further enhance their potency.
Progress in Using Systematic Reviews of Animal Studies to Improve Translational Research
Authors: C. R. Hooijmans, M. Ritskes-Hoitinga
Journal: PLoS Medicine (2013)

Carlijn Hooijmans and colleagues discuss developments that might improve the quality and translation of animal research, focusing on the importance of systematic reviews, the role of an international register of animal studies, and cooperation across the scientific community. Please see later in the article for the Editors' Summary