tbuckley/cabot-search huggingface dataset:
Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice
Authors: Jude A. Oben, Angelina Mouralidarane, Anne-Maj Samuelsson, Phillippa J. Matthews, Maelle L. Morgan, Chad Mckee, Junpei Soeda, Denise S. Fernandez-Twinn, Malgorzata S. Martin-Gronert, Susan E. Ozanne, Barbara Sigala, Marco Novelli, Lucilla Poston, Paul D. Taylor
Journal: Journal of Hepatology (2010)
HUMAN INFECTIONS WITH ORGANISM OF CONTAGIOUS ABORTION OF CATTLE AND HOGS
Authors: ALICE C. EVANS
Journal: JAMA (1927)

Although contagious abortion of cattle and other domestic animals has long been known to be a serious economic problem, and the possibility of human infections with the causal organism has been long in the minds of investigators, it is less than five years ago since the first human case of infection with this organism was recognized. Since then, a number of cases have been recognized in this and other countries. It is now an established fact that Brucella melitensis variety abortus may infect man.  The disease of man contracted from cattle or hogs is indistinguishable clinically from that prevalent in Mediterranean countries and known as undulant, or Malta fever. In Mediterranean countries it is contracted from goats by consuming infected milk or cheese, or by handling infected goats or infected goat meat, or from contaminated soil or dust. In this country, although the animal host is not the same as
American Heart Association Atrial Fibrillation Research Summit
Authors: N.A. Mark Estes, Ralph L. Sacco, Sana M. Al-Khatib, Patrick T. Ellinor, Judy Bezanson, Alvaro Alonso, Charles Antzelevitch, Randall G. Brockman, Peng-Sheng Chen, Sumeet S. Chugh, Anne B. Curtis, John P. DiMarco, Kenneth A. Ellenbogen, Andrew E. Epstein, Michael D. Ezekowitz, Pierre Fayad, Brian F. Gage, Alan S. Go, Mark A. Hlatky, Elaine M. Hylek, Michael Jerosch-Herold, Marvin A. Konstam, Richard Lee, Douglas L. Packer, Sunny S. Po, Eric N. Prystowsky, Susan Redline, Yves Rosenberg, David R. Van Wagoner, Kathryn A. Wood, Lixia Yue, Emelia J. Benjamin
Journal: Circulation (2011)

2][3] In response to the many challenges posed by AF, the American Heart Association (AHA) convened a conference in Washington, DC, on June 12-13, 2010, that included patients, nurses, physicians, and healthcare policy makers and regulators.In addition, basic, translational, population, outcomes, and clinical scientists participated (Appendix).The 22 presentations and 6 panel discussions were organized into 4 sessions: (1) Mechanisms of AF: Basic and Translational Science and Genetics; (2) Epidemiology, Outcomes, Cost, AF, and Stroke Prevention; (3) Meeting the Clinical Challenges in AF; and (4) Redefining the Therapeutic Goals of AF (Appendix).The focus of the present report is to provide an overview of the key concepts presented and the core recommendations made by the summit participants.
10 POTENTIAL ENHANCEMENT OF BOTH EARLY (EVR) AND SUSTAINED (SVR) VIROLOGICAL RESPONSE BY FLUVASTATIN IN CHRONIC HEPATITIS C TREATED WITH STANDARD PEGIFN-RIBAVIRIN THERAPY. A PILOT STUDY
Authors: E.F. Georgescu, L. Streba, R. Teodorescu, G. Mateescu, M. Tataru Abagiu
Journal: Journal of Hepatology (2011)
Abstract 702: Molecular responses to conductive interstitial thermal therapy of murine 4T1 breast carcinoma in surviving tumors, bone marrow and serum.
Authors: Beata D. Przybyla, Sagar Vishal
Journal: Cancer Research (2012)

Abstract Background: Ablation of solid tumor with a laser probe (CITT therapy) causes coagulative necrosis in central zone of tumor. The exposure to temperature gradient and immune responses to this treatment may affect homeostasis of surviving cells in surrounding area as well as induce systemic changes. The purpose of this study was 1/ to perform quantitative analyses of 29 transcripts of selected genes in tumor remaining after ablation and in bone marrow 2/ to evaluate changes in 16 cytokines in serum 3/ to compare levels of heat shock proteins in surviving tumors and in control tumors. Methods: Real-time RT-PCR and “delta delta” method was used to determine changes in transcripts in remaining tumors after treatment relative to control tumors. Cytokines in serum were tested using multiplex assay consisting of 16 murine cytokines. Expression of Hsp27 and Hsp70 proteins were determined with Western Blot. Results: 72 hours after thermal ablation of 4T1 tumors the following changes were found in tumor, in bone marrow and in serum of treated mice: 1/Out of 29 quantified transcripts, the level of four transcripts (Csf3 Lifr, Serpin1 and Vcam1) decreased significantly in remaining tumor. Majority of quantified transcripts had lower level in ablated than in control tumors. In bone marrow (BM) an opposite trend was observed. Levels of majority of quantified transcripts in BM increased after ablation as compared to control mice. The transcripts of genes: Cxcl12, Sele, Fgf2, Lifr, Mmp9, Timp3 were significantly higher in BM of mice after tumor ablation. 2/ Out of 16 chemokines tested, 4 chemokines (Il-5, Il-6, Ccl2 (MCP-1) and Ccl5 (RANTES) were detected in serum. There was a consistent increase of Il-5 in serum from ablated animals. 3/ Levels of Hsp27 and Hsp70 proteins were higher in remaining tumor as compared with control tumors. Conclusion The decrease of transcripts in remaining tumor of genes involved in adhesion, extracellular matrix degradation and tumor viability may inhibit re-growth of thermally ablated tumors. The increase of transcripts in bone marrow of treated mice indicates alteration of homeostasis of vascular niche and changes in function of mesenchymal stem cells. The increase of Hsp27 may inhibit apoptosis in remaining tumor. Up-regulation of Interleukin 5 suggests that this cytokine may play role in stimulation of anti-tumor immunity, as observed by other researchers. Further study is needed to determine whether the transcript reported here may be used as markers predicting long term effects of thermal ablation of solid tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 702. doi:1538-7445.AM2012-702
Abstract B10: LFA-1/ICAM-1 interaction switches on an orchestrated prometastatic microenvironmental shift during experimental liver metastasis of colon C26 cancer cells.
Authors: Aitor Benedicto, Joana Marquez, Elvira Olaso, Beatriz Arteta
Journal: Cancer Research (2015)

Abstract Intercellular adhesion molecule (ICAM)-1 is the main counter-receptor for the lymphocyte function associated antigen (LFA)-1. However, the role this interaction plays during liver metastasis of colorectal cancer cells and its underlying mechanisms remain unclear. Previously, we showed that mannose receptor (ManR) stimulation on liver sinusoidal endothelial cells (LSECs) resulted in a reduced cytotoxic potential of liver infiltrating lymphocytes (LIL) towards C26 murine colon carcinoma cells. Using ICAM-1 specific siRNAs in vivo, we aimed to study the role of hepatic ICAM-1 in the prometastatic shift of the liver microenvironment. Livers of control and silenced mice, 24 hours and 14 days after C26 cell inoculation, were compared for: percentage of detained C26 cells, number and volume of metastatic foci, levels of recruited immune, myofibroblastic and inflammatory cells and whole liver expression of pro-inflammatory genes. Detained cancer cells and metastatic foci number were reduced in silenced mice compared to controls, along with a decrease in myeloid suppressor cells and recruited macrophages and myofibroblasts. On the contrary, significant higher numbers of lymphocytic cells were observed in mice with reduced ICAM-1. Finally, silencing of ICAM1 resulted in altered total liver mRNA levels of proinflammatory factors in the tumor-bearing mice. Therefore, an orchestrated prometastatic program might be switched on in the liver microenvironment by LFA-1/ICAM-1 interaction which, in turn, could lead not only to a reduced antitumor citotoxicity but, also, to activation of the stromal compartment favoring tumor progression, and, opening liver's doors to tumor cells to aggressively metastasize. Based on these results, LFA-1/ICAM-1 interaction arises as a potential therapeutic target in cancer treatment. Citation Format: Aitor Benedicto, Joana Marquez, Elvira Olaso, Beatriz Arteta. LFA-1/ICAM-1 interaction switches on an orchestrated prometastatic microenvironmental shift during experimental liver metastasis of colon C26 cancer cells.. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr B10. doi:10.1158/1538-7445.CHTME14-B10
Do Specialists Screen for Breast Cancer?-Reply
Authors: Nancy Breen
Journal: JAMA (1995)

In Reply.  —National data support the conclusion of Drs Stoffer and Szpunar that specialists treating older women need to make an effort to ensure their patients are being adequately screened for breast cancer since older women are at greatest risk of breast cancer and are least likely to be screened.  Corroboration that specialists do not recommend many mammograms can be found in the National Ambulatory Medical Care Survey (NAMCS), 1 which shows, in 1991 for example, mammograms ordered or provided by 13 physician specialties. Eighty-seven percent of all mammograms were recommended by primary care (27%) and obstetrics/gynecology (40%). Patients seen by specialists may have had mammograms ordered by their primary care physicians, so the number of patients seen by specialists who underwent mammography would be higher than is apparent from these data.  Viewing these NAMCS data another way, mammograms are 1.7% of all the services ordered or provided by physicians
Compliance with Handwashing
Authors: Maryanne McGuckin
Journal: Annals of Internal Medicine (1999)

Letters17 August 1999Compliance with HandwashingMaryanne McGuckin, Dr ScEdMaryanne McGuckin, Dr ScEdUniversity of Pennsylvania Medical Center; Philadelphia, PA 19104 (McGuckin, ScEd)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-4-199908170-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Pittet and colleagues have documented the noncompliance of health care workers to basic hand hygiene practices (1). In 1984, we reported on the duration of handwashing in intensive care units and, like Pittet and colleagues, found that the average duration of handwashing by all personnel was 8.6 seconds. Duration did not differ significantly by level of patient contact but was slightly longer for high-level patient contact (2). Since 1981, when Albert and coworkers (3) brought the issue of handwashing noncompliance by health care workers to the attention of the medical community, 18 years of research on handwashing ...References1. Pittet D, Mourouga P, Pernege TV. Compliance with handwashing in a teaching hospital. The members of the Infection Control Program. Ann Intern Med. 1999;130:126-30. LinkGoogle Scholar2. Quraishi ZA, McGuckin M, Blais F. Duration of handwashing in intensive care units. A descriptive study. Am J Infect Control. 1984;11:83-7. CrossrefGoogle Scholar3. Albert RK, Condie F. Handwashing patterns in medical intensive care units. N Engl J Med. 1981;304:1465-6. CrossrefMedlineGoogle Scholar4. Larson EL, Bryan JL, Adler LM, Blane C. A multifaceted approach to changing handwashing behavior. Am J Infect Control. 1997;25:3-10. CrossrefMedlineGoogle Scholar5. McGuckin M, Waterman R, Porten L, et al. Patient education model for increasing handwashing compliance. Am J Infect Control. 1999; [in press]. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania Medical Center; Philadelphia, PA 19104 (McGuckin, ScEd) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCompliance with Handwashing in a Teaching Hospital Didier Pittet , Philippe Mourouga , Thomas V. Perneger , and It Is Time for Action: Improving Hand Hygiene in Hospitals John M. Boyce Compliance with Handwashing Didier Pittet and Thomas Perneger Metrics Cited ByHandwashing among female college studentsHand Washing: Simple, Cost Effective, Evidence Based … Lip Service! 17 August 1999Volume 131, Issue 4Page: 309-310KeywordsHealth care providersHygieneIntensive care unitsPatientsProspective studiesSoaps Issue Published: 17 August 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Diabetic Nephropathy: Urinary Albumin or Total Protein?
Authors: Edward A. Sasse, Basil T. Doumas, Jacob Lemann
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 August 1989Diabetic Nephropathy: Urinary Albumin or Total Protein?Edward A. Sasse, PhD, Basil T. Doumas, PhD, Jacob Lemann Jr., MDEdward A. Sasse, PhDSearch for more papers by this author, Basil T. Doumas, PhDSearch for more papers by this author, Jacob Lemann Jr., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-4-343_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Increased rates of albumin excretion into the urine at rest or after exercise exceeding about 3(μg/min or 45 mg/day are an early manifestation of diabetic nephropathy and may be a more sensitive indicator of the onset of diabetic nephropathy than the measurement of urinary total protein (1, 2). We evaluated whether measurement of urinary albumin, a more difficult and costly procedure, offers any advantage over the measurement of urinary total protein in following patients with established diabetic nephropathy.We studied 11 patients with established type I diabetic nephropathy. These patients were entered in the Collaborative Study of...References1. Mogensen C. Urinary albumin excretion in early and long term juvenile diabetes. Scand J Clin Lab Invest. 1971;28:183-93. CrossrefMedlineGoogle Scholar2. ParvingOxenbollSvendsenSandahl ChristiansenAnderson HPAJA. Early detection of patients at risk of developing diabetic nephropathy. A longitudinal study of urinary albumin excretion. Acta Endocrinologica. 1982;100:550-5. CrossrefMedlineGoogle Scholar3. ChaversBilousEllisSteffesMauer BREMS. Glomerular lesions and urinary albumin excretion in type I diabetes without overt proteinuria. N Engl J Med. 1989;320:966-70. CrossrefMedlineGoogle Scholar4. BrodowsNicholsShakerKubasik RDGN. Evaluation of a new radioimmunoassay for urinary albumin. Diabetes Care. 1986;9:189-93. CrossrefMedlineGoogle Scholar5. LemannDoumas JB. Proteinuria in health and disease assessed by measuring the urinary protein/creatinine ratio. Clin Chem. 1987;33:297-99. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEvaluation of a new fluorescent dye method to measure urinary albumin in lieu of urinary total proteinProteinuria, Hematuria, Hypertension, and Decreased Renal Function in a Patient With Diabetes for 9 Years 15 August 1989Volume 111, Issue 4Page: 343-344KeywordsAlbuminsExcretionExerciseMedical servicesProteinsUrine Issue Published: 15 August 1989 PDF DownloadLoading ...
Immunofluorescent Techniques in Clinical Diagnosis of Cutaneous Disease
Authors: DONALD M. KAY
Journal: Annals of Internal Medicine (1969)

The value of immunofluorescent techniques in the diagnosis of cutaneous diseases is illustrated by representative case reports. Specific staining patterns are seen in lupus erythematosus (LE), pemphigus vulgaris, and bullous pemphigoid. Skin specimens from 271 patients, 156 with LE, were examined by the direct immunofluorescent technique. Immunoglobulin deposition at the dermal-epidermal junction was noted in 92% of involved skin in systemic LE (SLE) and 88% in discoid LE (DLE). Clinically uninvolved skin in 56% of SLE patients was also positive. Sera from 325 patients were studied by indirect immunofluorescence with normal human skin as the antigenic substrate. Seventy-eight percent of SLE sera and 37% of DLE sera showed antinuclear antibodies to epidermal nuclei. In DLE this method appeared more sensitive than the leukocyte antinuclear antibody test. Antibodies to the basement membrane zone were seen only in bullous pemphigoid, and epidermal intercellular fluorescence was limited to pemphigus.
Conflicting Dispatches from the Tobacco Wars
Authors: Steven A. Schroeder
Journal: New England Journal of Medicine (2002)

Prevention and cessation are the two principal strategies in the battle against tobacco. Prevention efforts are aimed at discouraging people — generally children and youth — from starting to smoke. Prevention strategies include antitobacco education, countermarketing, guidance on ways to resist pressures to experiment with tobacco, increased taxes on tobacco products, advertising and marketing restrictions, placement of warning labels on products and advertisements, enforcement of laws governing the minimal age to purchase, and efforts to influence social norms.Equally important are efforts to help smokers quit. Nicotine is one of the most addictive substances we know, and although 70 percent . . .
Epidemic Plague in the Southwest.
Authors: William P. Reed
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Epidemic Plague in the Southwest.William P. Reed, M.D., Darwin L. Palmer, M.D., Ralph C. Williams Jr., M.D., Alexander L. Kisch, M.D.William P. Reed, M.D.Search for more papers by this author, Darwin L. Palmer, M.D.Search for more papers by this author, Ralph C. Williams Jr., M.D.Search for more papers by this author, Alexander L. Kisch, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-829_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHuman bubonic plague in the United States has markedly increased since 1965, with 17 cases recognized in 1969 to 1970. Clinical features of all cases were evaluated. Nine of the cases were seen by the authors, and clinical details of the others were obtained from attending physicians. The source of human infections is sylvatic plague endemic in wild rodents of the Southwest.One case was contracted through occupational exposure, four through recreation, seven near rural homes, three in rural hippie communes, and in two the source of exposure was unknown. All patients had fever, but in seven it was not... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: William P. Reed, M.D.; Darwin L. Palmer, M.D.; Ralph C. WilliamsJr., M.D.; Alexander L. Kisch, M.D.Affiliations: Albuquerque, N. Mex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5 Page: 829-829 Keywords Fevers Plague ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
Time delays in provision of thrombolytic treatment in six district hospitals. Joint Audit Committee of the British Cardiac Society and a Cardiology Committee of Royal College of Physicians of London.
Authors: J. S. Birkhead
Journal: BMJ (1992)

OBJECTIVE--To measure the delays between onset of symptoms and admission to hospital and provision of thrombolysis in patients with possible acute myocardial infarction. DESIGN--Observational study of patients admitted with suspected myocardial infarction during six months. SETTING--Six district general hospitals in Britain. SUBJECTS--1934 patients admitted with suspected myocardial infarction. MAIN OUTCOME MEASURES--Route of admission to hospital and time to admission and thrombolysis. RESULTS--Patients who made emergency calls did so sooner after onset of symptoms than those who called their doctor (median time 40 (95% confidence interval 30 to 52) minutes v 70 (60 to 90) minutes). General practitioners took a median of 20 (20 to 25) minutes to visit patients, rising to 30 (20 to 30) minutes during 0800-1200. The median time from call to arrival in hospital was 41 (38 to 47) minutes for patients who called an ambulance from home and 90 (90 to 94) minutes for those who contacted their doctor. The median time from arrival at hospital to thrombolysis was 80 (75 to 85) minutes for patients who were treated in the cardiac care unit and 31 (25 to 35) minutes for those treated in the accident and emergency department. CONCLUSION--The time from onset of symptoms to thrombolysis could be reduced substantially by more effective use of emergency services and faster provision of thrombolysis in accident and emergency departments.
DETERMINANTS OF VE/VCO2 SLOPE IN NORMAL INDIVIDUALS &amp;ndash; VENTILATORY EFFICIENCY IS MODIFIABLE WITH ENDURANCE TRAINING
Authors: Ryan M. Murphy, Rory B. Weiner, Stacyann S. Hough, Paul P. Pappagianopoulos, David M. Systrom, Adolph M. Hutter, Aaron L. Baggish, Gregory D. Lewis
Journal: Journal of the American College of Cardiology (2012)
RELAXANT ANAESTHESIA FOR ELECTROPLEXY
Authors: S. V. MARSHALL
Journal: American Journal of Psychiatry (1961)

1. A report covering 16,275 modified electro-convulsive treatments on 2,100 patients is submitted. 2. The scope and development of the procedure in the course of nearly 15 years is indicated. 3. The technique and dosages employed with the preferred drugs, thiopentone and suxamethonium chloride, are outlined. 4. There was no death immediately related to the therapy, but 2 patients died coincidentally during the course of their treatments. 5. Prolonged but non-fatal apnoea occurred in 9 cases, being readily controlled by proper oxygen therapy. Other complications were rare and of minor character. 6. The imperative need for such oxygen therapy in all patients subjected to modified electroplexy is emphasized. 7. Comment is made on various examples of false emphasis, especially regarding emergency developments, that occur in the relevant literature. 8. The possibility that repeated hypoxic episodes in elderly or debilitated patients might impair mental recovery is stressed.
MAN ACCORDING TO NATURE.
Authors: WILLIAM H. SCHROCK
Journal: JAMA (1883)

[Address before the District Medical Society of the Eleventh Congressional District of Ind., and published by request of the Society] The laws governing our physical origin and development are so numerous and so imperfectly understood, stood, and still less perfectly obeyed that we exclaim how fearful and wonderful the result. With all the recorded facts of the past, scientific men of this age ought to occupy a higher plane of action, in defense of nature's laws. Man's spiritual nature has been so clearly taught, and the laws for its progressive growth till its final consummation in perfection at death in Christ so well obeyed, that the believer in and obeyer of the Bible furnishes the world with the highest and most perfect psychical type of man. For elucidation and verification of this statement we refer you to those individuals, communities, states and nations that receive the Bible as the word