tbuckley/cabot-search huggingface dataset:
Safety in death
Authors: T. Dalrymple
Journal: BMJ (2011)

There is little doubt that an early death does no harm to a poet’s posthumous reputation. Dylan Thomas died at 39; Byron at 36; Shelley at 29; Keats at 24; Chatterton at 17. They died respectively of drink and cerebral haemorrhage, sepsis after venesection with a dirty lancet, drowning, tuberculosis, and arsenic poisoning, either suicidal or a self administered cure for venereal disease. It almost seems as if poetry were, one way or another, as hazardous an occupation as bomb disposal or Thai boxing; perhaps occupational health should look into it.

Rupert Brooke died aged 27 in 1915, and his books immediately went through many impressions: more, I suspect, than if he had survived. His most famous poems are the five sonnets he …
Deep venous thrombosis of the legs after strokes: Part 2-Natural history.
Authors: C Warlow, D Ogston, A S Douglas
Journal: BMJ (1976)

Seven out of 76 patients who had sustained a cerebrovascular accident suffered a pulmonary embolism as diagnosed at necropsy or by unequivocal antemortem criteria. A further five patients had probable embolisation diagnosed only by clinical and chest x-ray criteria. Eleven of these 12 patients had DVT as diagnosed by the 125I-fibrinogen technique. Though 125I-fibrinogen technique has its limitations, thrombosis seemed to be able to develop at several independent sites in the venous system of the leg.
Coronary Thrombosis and Myocardial Bridging
Authors: Christophe Bauters, Akram Chmait, Olivier Tricot, Nicolas Lamblin, Eric Van Belle, Jean Marc Lablanche
Journal: Circulation (2002)

A 28-year-old man presented with heavy chest pain that had lasted for 4 hours.Previously, he had been healthy, and he had no risk factors for coronary artery disease.Physical examination was unremarkable.The ECG showed an anterior myocardial infarction.Recombinant tissue plasminogen activator, heparin, and aspirin were administered, and the patient was referred to our center for emergency coronary angiography.A large intraluminal filling defect was observed in the left anterior descending artery (LAD) (Figures 1A and1B), which was
Ultrasound guided corticosteroid injection for plantar fasciitis: randomised controlled trial
Authors: A. M. McMillan, K. B. Landorf, M. F. Gilheany, A. R. Bird, A. D. Morrow, H. B. Menz
Journal: BMJ (2012)

<b>Objective</b> To investigate the effectiveness of ultrasound guided corticosteroid injection in the treatment of plantar fasciitis. <b>Design</b> Randomised, investigator and participant blinded, placebo controlled trial. <b>Setting</b> University clinic in Melbourne, Australia. <b>Participants</b> 82 people with a clinical and ultrasound diagnosis of plantar fasciitis unrelated to systemic inflammatory disease. <b>Interventions</b> Participants were randomly allocated to ultrasound guided injection of the plantar fascia with either 1 mL of 4 mg/mL dexamethasone sodium phosphate (experimental group) or 1 mL normal saline (placebo). Before injection the participants were given an ultrasound guided posterior tibial nerve block with 2% lidocaine (lignocaine). <b>Main outcome measures</b> Primary outcomes were pain, as measured by the foot health status questionnaire (0-100 point scale), and plantar fascia thickness, measured by ultrasound at 4, 8, and 12 weeks. <b>Results</b> Reduction in pain at four weeks favoured the dexamethasone group by 10.9 points (95% confidence interval 1.4 to 20.4, P=0.03). Between group differences for pain scores at eight and 12 weeks were not statistically significant. Plantar fascia thickness measured at four weeks favoured the dexamethasone group by −0.35 mm (95% confidence interval −0.67 to −0.03, P=0.03). At eight and 12 weeks, between group differences for plantar fascia thickness also favoured dexamethasone, at −0.39 mm (−0.73 to −0.05, P=0.02) and −0.43 mm (−0.85 to −0.01, P=0.04), respectively. The number needed to treat with dexamethasone for one successful outcome for pain at four weeks was 2.93 (95% confidence interval 2.76 to 3.12). There were no reported adverse events associated with the intervention. <b>Conclusion</b> A single ultrasound guided dexamethasone injection is a safe and effective short term treatment for plantar fasciitis. It provides greater pain relief than placebo at four weeks and reduces abnormal swelling of the plantar fascia for up to three months. However, clinicians offering this treatment should also note that significant pain relief did not continue beyond four weeks. <b>Trial registration</b> Australian New Zealand Clinical Trials Registry ACTRN12610000239066.
The relevance of skin prick tests for <i>Pityrosporum ovale</i> in patients with head and neck dermatitis
Authors: S. A. Devos, P. G. M. Van Der Valk
Journal: Allergy (2000)

Background: Patients with atopic dermatitis often develop immunoglobulin E antibodies against the yeast Pityrosporum ovale . This organism may produce positive skin prick reactions in a higher rate in patients with atopic dermatitis of the head, scalp, and neck region. Methods: We investigated whether positive prick tests to P. ovale were associated with a specific localization in the head and neck region. A total of 589 consecutive patients were prick tested with a P. ovale extract from ALK Abelló. Results: Thirty‐seven patients (6.3%) showed a positive reaction to the P. ovale extract. We could not find significant differences in the localizations of the dermatitis and the pattern of reaction to the tested intracutaneous allergens between the 37 patients positive to P. ovale and the control group of 55 subjects with negative reactions. In a subgroup, we found an elevated level of P. ovale ‐specific IgE in 100.0% of the patients with head and neck dermatitis, compared with 13.6% in the atopic dermatitis patients with lesions in any other localization. Conclusions: Our results clearly show that P. ovale ‐specific IgE is strongly related to the head and neck localization of atopic dermatitis, but RAST seems more sensitive than a prick test with the extract we used.
Edge of Smile or Brink of Guffaw? Clergyman/Linebacker Contemplates Draft of 1516
Authors: William H. B. Howard
Journal: JAMA (1989)

<h3>To the Editor. —</h3> In the article on Albrecht Dürer's "Portrait of a Clergyman" in the December 2 issue of<i>JAMA</i>, Dr Southgate describes the unknown cleric as being on "the edge of a smile." He surely would cross that edge, perhaps even to the brink of a guffaw, if he could read that his visage suggested "contemplation rather than action" and that "his small shoulders that slope in a gentle physique suggest a life more devoted to study than to deeds of physical prowess." To the contrary, this gentleman has the feral gaze and jaw of an outside linebacker set on a neck of impressive dimension. His shoulders, anything but small, are thick and sloping, like those found among premier athletes; under his cloak one can detect the bulge of a well-muscled chest. I suspect that if indeed this clergyman is contemplative, he probably is contemplating the joy of
Hospital-Specific Risk Factors for Filter Fever
Authors: M. Margaret Knudson
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
MDR-TB Has New Drug Foe After Fast-Track Approval
Authors: Rebecca Voelker
Journal: JAMA (2013)

The US Food and Drug Administration (FDA) in late December approved the first drug to treat potentially deadly multidrug-resistant tuberculosis (MDR-TB). Bedaquiline, a diarylquinoline antimycobacterial drug, got the go-ahead under the FDA's accelerated approval program for orphan drugs.
Modified Maze Procedure for Patients With Atrial Fibrillation Undergoing Simultaneous Open Heart Surgery
Authors: Yoshio Kosakai, Akira T. Kawaguchi, Fumitaka Isobe, Yoshikado Sasako, Kiyoharu Nakano, Kiyoyuki Eishi, Yoshitsugu Kito, Yasunaru Kawashima
Journal: Circulation (1995)

Background Persistent atrial fibrillation (AF) leaves patients symptomatic and at increased risk of thromboembolism even after otherwise successful cardiac surgery. Methods and Results To treat AF secondary to cardiac lesions requiring surgery, we combined a modified maze procedure in 101 patients simultaneously undergoing valvular procedures (87), repair of congenital anomalies (12), and other procedures (2), including 24 repeat operations. Duration of AF varied from 0.1 to 30 years (average±SD, 8.8±7.0 years); the f-wave voltage ranged from 0 to 0.45 mV (0.15±0.09 mV); and cardiothoracic ratio varied from 40% to 99% (63±9%). Aortic cross-clamp time varied from 75 to 229 minutes (138±31 minutes), with bypass time ranging from 119 to 326 minutes (217±42 minutes). There were two early deaths (2%), no late deaths, and one episode of transient neurological ischemic attack in follow-up ranging from 1.0 to 3.1 years, for a total of 190 patient-years. Postoperative rhythms were sinus in 83 patients (82%), junctional in 4 (4%), and persistent AF in 14 (14%), each of whom had mitral valve disease. Patients with other underlying pathology had complete recovery of atrial rhythm. A normal-sized A wave was detected in 88% for transtricuspid flow and in 73% for transmitral flow, suggesting concomitant recovery of atrial contraction. Among 36 patients without mechanical valves, 30 (83%) with atrial rhythm and contraction have been taken off anticoagulation therapy, including 10 who are free of all medication. Conclusions The results suggest that the combined approach is safe, effective, and indicated in patients who are judged capable of tolerating the procedure and likely to regain atrial rhythm.
The common structure is the affordance in the ecology
Authors: Paul J. Treffner
Journal: Behavioral and Brain Sciences (1999)

Millikan's discussion of substance concepts in terms of their information-gathering role ignores the analyses of information-based perception and action developed within the tradition of ecological psychology. Her introduction and use without definition of key Gibsonian terms such as “affordance” and “direct perception” leaves those of us investigating such concepts uncertain of the extent to which she appreciates their theoretical importance. Due recognition of the realist account of categorical perception developed by J. J. Gibson would provide mutual benefit to modern externalist philosophy as well as to experimental psychology and to those investigating the ecological approach to perception–action.
Traf1 Induction and Protection from Tumor Necrosis Factor by Nuclear Factor-κB p65 Is Independent of Serine 536 Phosphorylation
Authors: Carl Y. Sasaki, Colin F. Slemenda, Paritosh Ghosh, Theresa J. Barberi, Dan L. Longo
Journal: Cancer Research (2007)

Abstract Abnormal nuclear factor-κB (NF-κB) signaling has been attributed to the initiation and progression of cancer. Posttranslational modification of p65 facilitates optimal NF-κB signaling after activation. Here, we show that the phosphorylation of serine 536 was required for p65-mediated transcription and IκBα expression in fibroblasts. Furthermore, tumor necrosis factor (TNF) treatment slightly induced p65 phosphorylation, and both unphosphorylated and phosphorylated p65 translocated into the nucleus. The phosphorylation of serine 536 was not required for p65-mediated protection from TNF cytotoxicity and Traf1 induction in fibroblasts. Also, the corecruitment of p65 and RNA polymerase II to the Traf1 enhancer region did not require p65 phosphorylation. However, the corecruitment of p65 and RNA polymerase II to the Csf2 promoter required the phosphorylation of serine 536. These findings suggested that the requirement of serine phosphorylation at residue 536 and the distance between the NF-κB response element and the start of transcription may influence which genes will be transcribed. [Cancer Res 2007;67(23):11218–25]
Immune complexes as therapy for autoimmunity
Authors: Raphael Clynes
Journal: Journal of Clinical Investigation (2005)

For several decades, intravenous Ig has been used as treatment for a variety of immune-related diseases, including immune thrombocytopenic purpura (ITP), autoimmune neuropathies, systemic lupus erythematosus, myasthenia gravis, Guillain-Barré syndrome, skin blistering syndromes, and Kawasaki disease. Despite years of use, its mechanism of immunomodulation is still unclear. Recent studies using mouse models of ITP and arthritis, including one reported in this issue of the JCI, now provide some insights into this mechanism and the rationale for the development of Fcγ receptor–targeted therapeutics.
ANAPHYLACTIC REACTIONS TO CHYMOTRYPSIN INJECTIONS
Authors: George X. Trimble
Journal: JAMA (1960)

<h3>To the Editor:—</h3> Two clinical notes appeared recently inThe Journalconcerning anaphylactic reactions to aqueous chymotrypsin injections, one by Liebowitz and Ritter (Jan. 9, p. 159) and one by Rose (June 18, p. 796). The January note, which contained a statement that no similar instances could be found in the medical literature, elicited a letter, which also appeared inThe Journal(March 19, p. 1320), indicating that anaphylactic reactions to chymotrypsin without carrier had been recorded in a study in the<i>Proceedings of the Society of Experimental Biology and Medicine</i>(<b>71</b>:250 [June] 1949). In the June note mention was made of the fact that a survey of the literature revealed one previously recorded episode, which, however, was not related to either of the above-mentioned instances. The report of this latter episode was made by MacLaren and Aladjem (<i>J. Allergy</i><b>28</b>:89 [Jan.] 1957). This information is provided for
Improvement of myocardial perfusion and left ventricular function after coronary artery bypass grafting in patients with unstable angina.
Authors: A J Kolibash, J S Goodenow, C A Bush, M R Tetalman, R P Lewis
Journal: Circulation (1979)

Changes in myocardial perfusion and left ventricular function were evaluated pre- and post-operatively (3--6 months) in 14 patients with unstable angina who underwent coronary artery bypass surgery. Perfusion was studied with intracoronary and intragraft injections of radiolabeled macroaggregated albumin particles. Of 20 abnormal perfusion areas identified preoperatively, 13 demonstrated improved perfusion post-operatively. Segmental analysis of the left ventriculogram demonstrated improved wall motion in 29 abnormally contracting segments; 18 normalized. Areas which showed improvement of left ventricular perfusion were invariably associated with improvement of left ventricular wall motion. Five patients showed improvement in perfusion and contraction in areas of apparent old myocardial infarction. Thirteen of the 14 patients had significantly less angina whether or not there was evidence of improved perfusion. However, only those patients who demonstrated improved perfusion had a significant improvement in their treadmill exercise tolerance postoperatively. Thus, patients with unstable angina have perfusion defects which may be reversed as a result of saphenous vein graft surgery. Reversal of these perfusion abnormalities results in improved left ventricular performance and better exercise tolerance postoperatively.
Productance physicalism and a posteriori necessity
Authors: Don Dedrick
Journal: Behavioral and Brain Sciences (2003)

Abstract The problem of nonreflectors perceived as colored is the central problem for Byrne &amp; Hilbert's (B&amp;H's) physicalism. Vision scientists and other interested parties need to consider the motivation for their account of “productance physicalism.” Is B&amp;H's theory motivated by scientific concerns or by philosophical interests intended to preserve a physicalist account of color as a posteriori necessary?
From the Authors
Authors: P. Maestrelli
Journal: European Respiratory Journal (2004)

We thank D-J. Slebos and colleagues for their comments relating to our paper on the imbalance between haem oxygenase (HO)-1 and inducible nitric oxide synthase (iNOS) in the lungs of severe chronic obstructive pulmonary disease (COPD) patients [1].Our data showed that expression of HO-1 was decreased in alveolar macrophages in severe COPD, whereas iNOS expression in type-2 pneumocytes was increased.It is of great interest to see that the results provided by Slebos and colleagues confirm the part of our findings related to HO-1 expression in alveolar macrophages.Since the origin of macrophages retrieved by bronchoalveolar lavage is undetermined, the findings of Slebos and colleagues might indicate that the altered expression of HO-1 in COPD is not limited to the alveolar compartment, but extends to macrophages from the bronchial lumen.We believe that the presence of current smokers among our patients was a negligible confounding factor for the different expression of HO-1 in severe COPD as compared with control smokers without impairment of lung function [1].In fact, it was shown in our previous paper [2] that upregulation of HO-1 in alveolar macrophages of subjects with smoking history was irrespective of the fact they were current or ex-smokers.The data provided by Slebos and colleagues support the interpretation that HO-1 expression is not influenced directly by cigarette smoke.We are aware of the potential bias in studies performed on surgically resected specimens, due to the presence of cancer itself or to the selection of the worst part of the lungs in
Duration of Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation
Authors: Gennaro Giustino, Usman Baber, Samantha Sartori, Roxana Mehran, Ioannis Mastoris, Annapoorna S. Kini, Samin K. Sharma, Stuart J. Pocock, George D. Dangas
Journal: Journal of the American College of Cardiology (2015)
The Role of Defective Mismatch Repair in Small Bowel Adenocarcinoma in Celiac Disease
Authors: D. Dean Potter, Joseph A. Murray, John H. Donohue, Lawrence J. Burgart, David M. Nagorney, Jon A. van Heerden, Matthew F. Plevak, Alan R. Zinsmeister, Stephen N. Thibodeau
Journal: Cancer Research (2004)

Abstract Celiac disease is associated with an increased risk of small bowel adenocarcinoma. The aims of this study were to investigate the molecular basis, assess outcomes, and identify clinicopathologic characteristics of small bowel adenocarcinoma in celiac disease. Retrospective case control cohort study of all celiac disease patients treated at our institution for small bowel adenocarcinoma and matched control patients with sporadic small bowel adenocarcinoma from July 1960 to November 2002. Mismatch repair (MMR) status was accessed by testing tissue for microsatellite instability (MSI) and for hMLH1 and hMSH2 protein expression. Over a 40-year time period, 18 patients with small bowel adenocarcinoma and celiac disease were treated at the Mayo Clinic. One celiac disease patient was excluded. High-frequency MSI (MSI-H) was identified in 8 of 11 (73%) and 2 of 22 (9%) available small bowel adenocarcinoma specimens in the celiac disease and control groups, respectively. In the celiac disease group, MSI-H was associated with loss of hMLH1 and hMSH2 in 6 and 1 specimens, respectively. Loss of hMLH1 occurred in both control tumors. Stage was associated with celiac disease status (P = 0.018), and 78% of controls were stage III or IV compared with 47% of celiac disease patients. Overall, survival was better (P = 0.025) in the celiac disease group compared with stage-matched controls. Celiac disease patients with small bowel adenocarcinoma had a high incidence defective MMR (73%) compared with controls and had better survival compared with stage-matched controls. In addition, celiac disease patients presented more frequently with early-stage small bowel adenocarcinoma. The better survival and earlier presentation of small bowel adenocarcinoma in celiac disease appears to be biologically associated with defective MMR.
Systemic Corticosteroid Therapy for Acute Sinusitis
Authors: Roderick P. Venekamp, Matthew J. Thompson, Maroeska M. Rovers
Journal: JAMA (2015)

Are oral or parenteral corticosteroids associated with improved clinical outcomes in patients with acute sinusitis compared with placebo or nonsteroidal anti-inflammatory drugs (NSAIDs)? Oral corticosteroids combined with antibiotics may be associated with modest benefit for short-term relief of symptoms in adults with severe symptoms of acute sinusitis compared with antibiotics alone. Oral corticosteroids as monotherapy are not associated with improved clinical outcomes in adults with clinically diagnosed acute sinusitis.
The right to left ventricular glucose uptake ratio predicts left ventricular function recovery after revascularization in heart failure
Authors: Heikki Ukkonen, Rob deKemp, Terrence D. Ruddy, Ross A. Davies, Linda Garrard, May Aung, Gunter Firnau, Paul Hendry, Rob S. Beanlands
Journal: Journal of the American College of Cardiology (2003)
CD40 Ligand Inhibits Endothelial Cell Migration by Increasing Production of Endothelial Reactive Oxygen Species
Authors: Carmen Urbich, Elisabeth Dernbach, Alexandra Aicher, Andreas M. Zeiher, Stefanie Dimmeler
Journal: Circulation (2002)

Background— The CD40/CD40 ligand system is involved in atherogenesis. Activated T lymphocytes and platelets, which express high amounts of CD40 ligand (CD40L) on their surface, contribute significantly to plaque instability with ensuing thrombus formation, leading to acute coronary syndromes. Because reendothelialization may play a pivotal role for plaque stabilization, we investigated a potential role of CD40L on endothelial cell (EC) migration. Methods and Results— Stimulation of ECs with recombinant CD40L prevented vascular endothelial growth factor (VEGF)-induced EC migration, as determined by a “scratched wound assay.” In addition, activated T lymphocytes and platelets significantly inhibited VEGF-induced EC migration and tube formation in vitro. Because the activation of endothelial nitric oxide (NO) synthase and the release of NO are required for EC migration and angiogenesis, we analyzed the effect of NO. Coincubation with the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) did not reverse the inhibitory effect of CD40L on VEGF-induced EC migration and tube formation. In addition, EC migration induced by SNAP was completely inhibited by CD40L. CD40L, however, induced the production of reactive oxygen species and reduced endothelial NO bioavailability. This reactive oxygen species-dependent effect of CD40L stimulation was reversed with vitamin C or N -acetylcysteine. Conclusions— The activation of the CD40 receptor inhibits EC migration by increasing reactive oxygen species. The blockade of EC migration by CD40L may critically affect endothelial regeneration after plaque erosion and thereby may contribute to the increased risk for development of acute coronary events in patients with high circulating levels of CD40L.
Dynamic Encoding of Perception, Memory, and Movement in a C. elegans Chemotaxis Circuit
Authors: Linjiao Luo, Quan Wen, Jing Ren, Michael Hendricks, Marc Gershow, Yuqi Qin, Joel Greenwood, Edward R. Soucy, Mason Klein, Heidi K. Smith-Parker, Ana C. Calvo, Daniel A. Colón-Ramos, Aravinthan D.T. Samuel, Yun Zhang
Journal: Neuron (2014)