tbuckley/cabot-search huggingface dataset:
Abstract 3893: Endocan is upregulated on tumor vessels in invasive bladder cancer and mediates VEGF-A-induced angiogenesis.
Authors: Filip Roudnicky, Cedric Poyet, Peter J. Wild, Sarah Krampitz, Fabrizia Negrini, Reto Huggenberger, Anja Rogler, Robert Stöhr, Arndt Hartmann, Maurizio Provenzano, Vivianne I. Otto, Michael Detmar
Journal: Cancer Research (2013)

Abstract Tumor-associated blood vessels differ from normal vessels at the morphological and molecular level. Proteins that are only present on tumor vessels may serve as biomarkers and as therapeutic targets for inhibition of angiogenesis in cancer. To identify factors contributed by the tumor-associated endothelium, we performed immuno-laser capture microdissection (i-LCM) of blood vascular endothelial cells in conjunction with transcriptional profiling from surgically harvested cancer and normal matched bladder tissue of five patients with invasive bladder cancer. Comparing the transcriptional profiles of blood vascular endothelium from human invasive bladder cancer and from normal bladder tissue, we found that endocan (endothelial cell-specific molecule-1) was highly elevated on tumor vessels and associated with the filopodia of angiogenic endothelial tip cells in invasive bladder cancer. Notably, endocan expression on tumor vessels strongly correlated with the tumor stage and invasiveness and predicted a shorter recurrence-free survival time in non-invasive bladder cancers. Furthermore, both endocan and VEGF-A levels were significantly higher in plasma of patients with invasive bladder cancer (n=53) compared to healthy individuals (n=60). Using cultured blood vascular endothelial cells and an in vivo transgenic mouse model we found that endocan expression was strongly upregulated by VEGF-A activation of VEGFR-2. RNA interference-mediated knockdown of endocan in cultured blood vascular endothelial cells revealed that endocan was required for the promotion of cell migration and tube formation by VEGF-A. Furthermore, we found that endocan potentiates VEGFR-2 phosphorylation in response to VEGF-A. Therefore, blocking the interaction of endocan with either VEGFR-2 or VEGF-A might represent a promising approach for inhibiting tumor angiogenesis. Endocan might also serve as a novel biomarker for monitoring disease progression and the efficacy of VEGF-A-targeting therapies in patients with bladder cancer. Citation Format: Filip Roudnicky, Cedric Poyet, Peter J. Wild, Sarah Krampitz, Fabrizia Negrini, Reto Huggenberger, Anja Rogler, Robert Stöhr, Arndt Hartmann, Maurizio Provenzano, Vivianne I. Otto, Michael Detmar. Endocan is upregulated on tumor vessels in invasive bladder cancer and mediates VEGF-A-induced angiogenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3893. doi:10.1158/1538-7445.AM2013-3893
Social Security Numbers in Record Filing
Authors: Ernest A. Bragg
Journal: JAMA (1965)

<h3>To the Editor:—</h3> General hospitals have complex filing problems involving storage of medical records on in-patients, emergency room records, x-ray films and reports, slides and reports on autopsies and surgical tissue examinations, laboratory examination reports, and reports on electrocardiograms. Depending upon the size and type of the hospital, its record-keeping problems may also include records from several out-patient clinics, special laboratories, treatment departments, and research projects. To avoid alphabetic filing by the patient's name, it has become almost a universal custom to file medical records, x-rays, etc, by assigned numbers. Numerical filing eliminates the disadvantages of hunting through filed record material stored alphabetically. It introduces the alternate problems of assigning numbers for each patient in each department and looking up the number each time the file material on a particular patient is needed for readmission or reexamination. The problem of frequent references to material on the same patient filed in
Effects of rhIGF-I administration on bone turnover during short-term fasting.
Authors: S K Grinspoon, H B Baum, S Peterson, A Klibanski
Journal: Journal of Clinical Investigation (1995)

Insulin-like growth factor-I (IGF-I) is a nutritionally dependent bone trophic hormone which stimulates osteoblast function and collagen synthesis in vivo and in vitro. We hypothesized that in the fasting state, IGF-I levels would decline significantly and would establish a model in which we could investigate the effects of IGF-I administration on bone turnover. We therefore studied 14 normal women ages 19-33 (mean, 24 +/- 4 [SD] years) during a complete 10-d fast. After 4 d of fasting, subjects were randomized to receive rhIGF-I or placebo subcutaneously twice a day for 6 d. Bone turnover was assessed using specific markers of formation (osteocalcin and type I procollagen carboxyl-terminal propeptide [PICP]) and resorption (pyridinoline, deoxypyridinoline, type I collagen crosslinked N-telopeptide [N-telopeptide] and hydroxyproline). Serum levels of PICP and osteocalcin decreased from 143 +/- 52 to 60 +/- 28 ng/ml (P = 0.001) and from 7.6 +/- 5.4 to 4.2 +/- 3.1 ng/ml (P = 0.001) respectively with 4 d of fasting. Urinary excretion of pyridinoline and deoxypyridinoline decreased from 96 +/- 63 to 47 +/- 38 nmol/mmol creatinine (P < 0.05) and from 28 +/- 17 to 14 +/- 11 nmol/mmol creatinine (P < 0.05) respectively. Mean IGF-I levels decreased from 310 +/- 81 to 186 +/- 78 ng/ml (P = 0.001). In the second part of the experimental protocol, serum osteocalcin and PICP levels increased 5- and 3-fold, respectively with rhIGF-I administration and were significantly elevated compared with the placebo group at the end of treatment (20.9 +/- 17.3 vs. 5.9 +/- 6.4 ng/ml for osteocalcin [P < 0.05] and 188 +/- 45 vs. 110 +/- 37 ng/ml for PICP [P < 0.05]). In contrast, all four markers of bone resorption, including urinary pyridinoline, deoxypyridinoline, N-telopeptide and hydroxyproline were unchanged with rhIGF-I administration. This report is the first to demonstrate that bone turnover falls rapidly with acute caloric deprivation in normal women. RhIGF-I administration uncouples bone formation in this setting by significantly increasing bone formation, but not resorption. These data suggest a novel use of rhIGF-I to selectively stimulate bone formation in states of undernutrition and low bone turnover.
Hip Fracture: A Complex Illness Among Complex Patients
Authors: Joanne Lynn
Journal: Annals of Internal Medicine (2012)

Letters3 January 2012Hip Fracture: A Complex Illness Among Complex PatientsJoanne Lynn, MD, MA, MSJoanne Lynn, MD, MA, MSFrom Altarum Institute, Washington, DC 20036.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-1-201201030-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hung and Morrison's editorial (1) on management of hip fracture does not address the patient in whom hip fracture will not be surgically repaired. I have had only a couple such patients who made the decision not to have surgery and were more than a few days from death. Both were competent to make their own choices, and despite encouragement to reconsider, these elderly patients stood firm and chose to die in their beds.In caring for these patients, I could not convince anesthesiologists to consider regional approaches that might mitigate the need to use substantial narcotic ...Reference1. Hung WW, Morrison RS. Hip fracture: a complex illness among complex patients [Editorial]. Ann Intern Med. 2011;155:267-8. [PMID: 21844553] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Joanne Lynn, MD, MA, MSAffiliations: From Altarum Institute, Washington, DC 20036.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHip Fracture: A Complex Illness Among Complex Patients William W. Hung and R. Sean Morrison Hip Fracture: A Complex Illness Among Complex Patients Rajiv K. Dixit Hip Fracture: A Complex Illness Among Complex Patients William W. Hung and R. Sean Morrison Metrics 3 January 2012Volume 156, Issue 1_Part_1Page: 70-71KeywordsAnalgesiaAnesthesiaConflicts of interestElderlyHip fracturesHygieneSurgerySurgical repair ePublished: 3 January 2012 Issue Published: 3 January 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Tobacco smoke‐induced left ventricular remodelling is not associated with metalloproteinase‐2 or ‐9 activation
Authors: Edson Castardeli, Daniella R. Duarte, Marcos F. Minicucci, Paula S. Azevedo, Beatriz B. Matsubara, Luiz S. Matsubara, Álvaro O. Campana, Sergio A.R. Paiva, Leonardo A.M. Zornoff
Journal: European Journal of Heart Failure (2007)
CRANIECTOMY—AN IMPROVED TECHNIQUE.
Authors: A. H. MEISENBACH
Journal: JAMA (1895)

In this paper I do not wish to discuss the rationale of, or the indications for, craniectomy; but wish to limit myself to the description of an operation which differs in its technique from those heretofore described. Craniectomy may be either linear, circular or irregular in form; may be confined to one or both sides of the cranium, and may be anterior or posterior. The method of performing craniectomy (one-sided linear) employed by most surgeons, is as follows: a large scalp flap is cut so as to expose the entire field of operation on the bone beneath it. The flap has its base at the base of the skull and extends in a curved line along the sagittal suture, beginning at the hair line of the forehead anteriorly to the coronal suture, and extending posteriorly across the lambdoid suture onto the occipital bone. Its upper border runs parallel with the
APHONIA FROM PARALYSIS OF THE LEFT VOCAL CORD
Authors: Nicholas Lukin
Journal: JAMA (1923)

<h3>History.</h3> —A woman, aged 23, whose family history is unimportant, had had diphtheria, scarlet fever, and complicating nephritis in childhood; also sore throat a few times later on. As she grew up and went through school, her health was considered good. About eight years ago, she came under my observation through her mother, who was not satisfied with her frequently "feeling tired," and her worried appearance. An altered mitral first sound, coupled with her past history, suggested the possibility of a developing mitral stenosis. It did not permit her to finish school, and she rested during a long period of time. Gradually, definite cardiac signs of a mitral stenosis developed. In appearance, however, she improved; she gained some weight, went dancing, and assisted her father in his office. About two years ago, a mild attack of appendicitis laid her up for a week. She had apppendicular pains since on several
HLA Class II Genes in Soybean Epidemic Asthma Patients
Authors: JOAN B. SORIANO, GUADALUPE ERCILLA, JORDI SUNYER, FRANCISCO X. REAL, CONXI LÁZARO, MARÍA J. RODRIGO, XAVIER ESTIVILL, JOSEP ROCA, ROBERT RODRÍGUEZ-ROISÍN, FERRAN MORELL, JOSEP M. ANTÓ
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

From 1981 to 1987, 26 outbreaks of asthma caused by the inhalation of soybean dust, affecting a total of 688 individuals, were detected in Barcelona, Spain. Because only a small proportion of asthmatic individuals living in Barcelona expressed the epidemic phenotype, it is hypothesized that a genetically determined human leukocyte antigen (HLA) Class II factor could have played a role in the susceptible individuals. Accordingly, we studied the distribution of both HLA-DR and HLA-DQ in soybean epidemic asthmatic patients. An analysis of the HLA-DR and HLA-DQ genes for genetic polymorphisms of the beta 1 chain was done with the polymerase chain reaction (PCR) in 78 soybean epidemic asthma patients, and the findings were compared with those for 67 nonepidemic asthmatic individuals and 168 individuals from the general population. An allelic disequilibrium could be established; the risk of epidemic asthma was particularly associated with the DRB1*13 gene (p value corrected for multiple comparisons < 0.02). The association observed for the DRB1*13 gene was stronger in individuals in the lowest tertile for total IgE, with an estimated risk with a 95% confidence interval (CI), of 14.5 (1.6 to 130.8). The combination of two genes from among the DRB1*05-05, DRB1*05-06, and DRB1*06-06 genes was present in epidemic asthmatic subjects only. No association with an HLA-DQB1 allele could be observed. Genetic predisposition could contribute to the response of some asthmatic patients to exposure to soybean dust, having led to their being affected during the epidemics of asthma in Barcelona.
Theophylline and Atrioventricular Block
Authors: Richard L. Weiss
Journal: Annals of Internal Medicine (1996)

Letters1 September 1996Theophylline and Atrioventricular BlockRichard L. Weiss, MDRichard L. Weiss, MDRobert Wood Johnson Medical School, Camden, NJ 08103Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with great interest the recent report by Bertolet and colleagues [1] on theophylline for the treatment of atrioventricular block after myocardial infarction. The article was innovative but left many questions unanswered. In the Methods section, the authors discussed administering theophylline as a slow intravenous injection at a rate of 100 mg/min until a maximum of 250 mg was given. Clearly, in all eight patients, the medication did work to convert bradyarrhythmia. Three patients each received 250 mg of theophylline, but the time to conversion was 1 minute, 3 minutes, 1 minute, respectively.What were the ...REFERENCE1. Bertolet BD, McMurtrie EB, Hill JA, Belardinelli L. Theophylline for the treatment of atrioventricular block after myocardial infarction. Ann Intern Med. 1995; 123:509-11. Google Scholar Author, Article, and Disclosure InformationAffiliations: Robert Wood Johnson Medical School, Camden, NJ 08103 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1996Volume 125, Issue 5Page: 421KeywordsArrhythmiaBradycardiaCardiac pacingElectrophysiological techniquesIntravenous injectionsMyocardial infarctionPatients Issue Published: 1 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Presence of Rhinovirus in Lower Airways of Patients with Bronchial Asthma
Authors: Monika Woś, Marek Sanak, Jerzy Soja, Henryk Olechnowicz, William W. Busse, Andrew Szczeklik
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

The common cold virus, human rhinovirus (HRV), is the most frequent cause of asthma exacerbations. However, a possible contribution of HRV to the pathogenesis of chronic, persistent asthma has not been defined.To determine if patients with stable asthma, who are free of clinical signs of a respiratory infection for at least 3 weeks, harbor HRV in their bronchi more frequently than nonasthmatic control subjects, and whether clinical features of asthma are associated with the presence of HRV.Immunohistochemistry and the indirect in situ reverse transcription-polymerase chain reaction method were used to detect the presence of HRV in bronchial mucosal biopsies in patients with asthma and nonasthmatic control subjects.HRV was found by immunohistochemistry in 9 of 14 bronchial biopsies from subjects with asthma (64.3%) and 2 of 6 nonasthmatic control subjects (33.3%) (P = 0.38). With the more sensitive indirect in situ reverse transcription-polymerase chain reaction method, HRV was found in the mucosal biopsies of 73% of patients with asthma and 22% of nonasthmatic control subjects (P < 0.001). Subjects positive for HRV had lower pulmonary function, higher numbers of blood eosinophils and leukocytes, and eosinophilic infiltration in bronchial mucosa.HRV was detected in the lower airway tissue of patients with asthma significantly more often than in nonasthmatic subjects, and its presence was associated with clinical features of more severe disease.
Role of Exercise and Lung Function in Predicting Work Status in Cystic Fibrosis
Authors: Despina D. Frangolias, Caroline L. Holloway, Sverre Vedal, Pearce G. Wilcox
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

With larger numbers of adult patients with cystic fibrosis (CF) in the workplace, the issue of disability has arisen increasingly. We examined relationships between measures of pulmonary impairment and work/school capability and then determined whether quantification of aerobic fitness improved predictability of disease-related disability. We studied 73 patients with CF who performed lung function and exercise capacity tests, completed a work/education questionnaire, and were scored for clinical and chest radiographic status. Patients who were characterized as unemployed and in poor health had more severe pulmonary disease according to American Thoracic Society impairment/disability criteria. Subjects were further classified into three groups based on employment or education status over the preceding 12 months. FEV1, maximal oxygen consumption, Schwachman–Kulczycki clinical and Brasfield radiographic scores, and frequency of pulmonary exacerbations over 2 years were associated with disability, but change in FEV1 over 2 years and oxygen saturation at rest or exertion were not. FEV1 and Schwachman–Kulczycki scores were the best independent predictors of impairment/disability; specific thresholds used in other pulmonary diseases were of limited utility. We conclude that after accounting for either current level of FEV1 or Schwachman–Kulczycki scores, no other physiological or clinical measures contribute to predicting limitation in a work or school environment.
Integrated record keeping as an essential aspect of a primary care led health service
Authors: M. Rigby, R. Roberts, J. Williams, J. Clark, A. Savill, B. Lervy, G. Mooney
Journal: BMJ (1998)

Three separate policy themes have been identified as important for the future development of effective health care in the United Kingdom.These are a focus on the extended primary care team as the prime means of healthcare delivery, 1-3 improved keeping of patients' records and communication between professionals, 4 and greater recognition of consumers' wishes for good quality, well coordinated care. 5However, these three strands are generally being addressed separately, and inherited traditions of professional practice reinforce incompatibilities between them, although some official publications have recognised the need for innovation and greater flexibility. 6ood records are at the heart of professional practice.Moreover, good healthcare delivery, best use of healthcare resources, and delivery of a cohesive service that satisfies an increasingly demanding population can be achieved only with good communications and a shared clinical perception of a patient's problems and needs-seamless care is difficult to achieve without seamless information. 7Thus a new generation of integrated records is required to support the expanding primary care team.
Insulin resistance, viral load and response to peginterferon and ribavirin in patients with chronic hepatitis C virus infection
Authors: C.-Y. Dai, J.-F. Huang, M.-Y. Hsieh, W.-L. Chuang, M.-L. Yu
Journal: Gut (2010)

We read the article by Moucari et al in Gut recently1 with great interest. The authors concluded that insulin resistance (IR) is correlated independently with serum hepatitis C virus (HCV)-RNA and frequently encountered in patients with HCV genotype 4 (HCV-4) infection. Also IR is a major predictor of response to peginterferon and ribavirin in 108 HCV-4 patients receiving a 48-week course of peginterferon plus ribavirin.

In our previous study we enrolled 330 Taiwanese patients with chronic hepatitis C (CHC) (150 HCV genotype 1 (HCV-1) and 180 genotype non 1 (HCV-non 1) to evaluate the association between homeostasis model assessment of IR (HOMA-IR) and response to therapy.2 We checked the association between HOMA-IR and serum HCV-RNA level. The …
Intra-Aneurysmal Hemodynamics--Jet Action
Authors: WILLIAM J. GERMAN, SAMUEL P. W. BLACK
Journal: Circulation Research (1955)

Jet action from experimental "berry" aneurysms was evaluated as part of a long-range study of stress-strain-time relations of aneurysmal rupture. It was apparent that free jet action was a potent stress agent upon matter in its path. Calculated velocities of free jets ranged up to 477 cm. per sec. Supplementary observations were made upon jets from glass-model aneurysms, including the jet effects upon gelatin blocks cast about the models. Coefficients of velocity were determined for the various jets studied and the results were correlated with theoretic hydraulics.
Role of fibreoptic bronchoscopy in management of pneumonia in acquired immune deficiency syndrome.
Authors: J B Warren, R J Shaw, J N Weber, D A Holt, E E Keal, A J Pinching
Journal: BMJ (1985)

A propos de 42 bronchoscopies chez 30 malades atteints de SIDA et presentant des symptomes de pneumopathie. La methode est sans danger et permet un diagnostic exact dans 85% des cas: differenciation de l'infection par Pneumocystis carinii d'avec d'autres infections opportunistes
Dimeric Gold Nanoparticle Assemblies as Tags for SERS‐Based Cancer Detection
Authors: A. Swarnapali D. S. Indrasekara, Bryan J. Paladini, Dominik J. Naczynski, Valentin Starovoytov, Prabhas V. Moghe, Laura Fabris
Journal: Advanced Healthcare Materials (2013)

Abstract Herein, a new class of multifunctional materials combining a clustered nanoparticle‐based probe is presented for surface enhanced Raman scattering (SERS)‐based microscopy and surface functionalization for tissue targeting. Controlled assembly of spherical gold nanoparticles into dimers (DNP‐REP) is engineered using a small, rigid Raman‐active dithiolated linking reporter (REP) to yield narrow internanoparticle gaps and to strategically generate the “hot spot” while concurrently placing the reporter within the region of highest SERS enhancement. Peptide functionalized DNP‐REP materials are highly stable even upon incubation with living cells and show controlled levels of binding and intracellular endocytosis. To demonstrate the functionality of such probes for disease detection, differentially targeted DNP‐REPs are incubated over various time points with cultured human glioblastoma cells. Using human glioblastoma cells, the SERS maps of targeted tumor cells show the markedly enhanced signals of the DNP‐REP, compared to conventional confocal fluorescence based approaches, especially at low incubation times. Even with as few as 40 internalized DNP‐REP, a relatively intense SERS signal is measured, demonstrating the high signal to noise ratio and inherent biocompatibility of the materials. Thus, these Raman reporter‐based nanoparticle cluster probes present a promising and versatile optical imaging tool for fast, reliable, selective, and ultrasensitive tissue targeting and disease detection and screening.
TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial
Authors: Hervé Bonnefoi, Martine Piccart, Jan Bogaerts, Louis Mauriac, Pierre Fumoleau, Etienne Brain, Thierry Petit, Philippe Rouanet, Jacek Jassem, Emmanuel Blot, Khalil Zaman, Tanja Cufer, Alain Lortholary, Elisabet Lidbrink, Sylvie André, Saskia Litière, Lissandra Dal Lago, Véronique Becette, David A Cameron, Jonas Bergh, Richard Iggo
Journal: The Lancet Oncology (2011)
Three-Dimensional Analysis of Budding Sites and Released Virus Suggests a Revised Model for HIV-1 Morphogenesis
Authors: Lars-Anders Carlson, John A.G. Briggs, Bärbel Glass, James D. Riches, Martha N. Simon, Marc C. Johnson, Barbara Müller, Kay Grünewald, Hans-Georg Kräusslich
Journal: Cell Host & Microbe (2008)