tbuckley/cabot-search huggingface dataset:
Hydrophobia in California.
Authors: Alfred C. Croftan
Journal: JAMA (1899)

Pasadena, Cal., May 22, 1899.  To the Editor:  —I wish to report the occurrence of the first truly authenticated case of hydrophobia in Southern California. The onset, course of the disease, and death were typic, and subdural injections of cerebrospinal fluid of the patient into rabbits were followed by death of one of the three animals experimented on (after a period of twelve days) in convulsions followed by paralysis. As the whole case was a characteristic one (and it was my privilege to see a great many cases with Pasteur, in Paris, in the spring of 1893), the details are hardly worth publishing; but as Southern California has so far been considered exempt from this disease, the occurrence of this first authenticated case, I believe, merits chronicling in the interest of medical statistics and of public sanitation. Any details of the case, of postmortem finding, etc., will be gladly forthcoming,
Clinical Medicine and the Psychotic Patient
Authors: Paul E. Huston
Journal: JAMA (1961)

The authors believe that there are certain special characteristics of medical practice in a neuropsychiatric hospital. Some disorders are peculiar to the psychotic patient, such as the exhaustion syndrome and megacolon, and some disorders are rarely seen in the psychotic patient, such as acute bronchial asthma, hay fever, and rheumatoid arthritis. Another distinctive feature is that many patients who are developing or suffering from serious physical illnesses make no complaints or distort or disguise their complaints so that the physician may be misled or must pay special attention to unusual and somewhat atypical forms of behavior. Interviewing the patient to get a clear description of the complaints may involve a physician in the psychotic thinking of the patient. The history of familial diseases is apt to be unreliable when obtained from the patient, as is his own past medical and surgical history. Furthermore, the patient may need special handling during
What is publication?
Authors: S. Erny, H. Maradit-Kremers
Journal: BMJ (1999)

Low dose aspirin for preventing and treating pre-eclampsia Author of editorial did not criticise studies' methodologyEditor-In her editorial discussing the value or otherwise of aspirin for preventing and treating pre-eclampsia Duley wonders why the small trials have such different results from the large trials. 1 We suggest the following answer.Evidence based medicine means integrating individual skill with the best available evidence from systematic research.Duley's conclusions, based on several multicentre studies, seem to rely on the conclusions of these studies without her making criticisms of the methodology used.Firstly, the timing of the start of treatment with low dose aspirin is important.The studies consistently fail to show the percentage of women who were < 16 weeks pregnant, the crucial time when maximum trophoblastic invasion is taking place (table ).This issue was raised by de Swiet in Bower's news article 2 and by Beaufilis et al. 3 Secondly, the dose of aspirin used in the later large trials is low.A meta-analysis by Leitich et al (not quoted in the editorial) shows that aspirin was more effective at higher doses (100-150 mg/day) than at lower doses (50-80 mg/day). 4It seems that these large studies have looked at the wrong dose of aspirin used at the wrong time of pregnancy.The editorial's conclusions are based on trials with flawed methodology.The question of whether aspirin given in early pregnancy in an appropriate dose is effective in preventing pre-eclampsia remains unanswered.
Prepublication Release of Medical Research
Authors: Phil B. Fontanarosa
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIRECTIONS IN MEDICAL LICENSURE
Authors: George H. Lage
Journal: JAMA (1966)

In this issue the Council on Medical Education presents the 64th annual report on medical licensure (pp 857-906). The statistical and factual material assembled in the report represents the usual careful and commendably complete survey of the field expected of the Council.  The Federation of State Medical Boards of the United States and the individual member boards have long been indebted to the Council for these reports, as have the members of the profession at large. The Federation and the Council have enjoyed a long and pleasant association over many years. The evaluation of candidates for licensure has required that the boards be deeply concerned with the quality of medical education. There has been, therefore, a very natural community of interest between the Federation and the Council in their mutual desire for high and uniform standards in medical education. It is no small tribute to the activities of the Council
Depth of Excision of Melanomas
Authors: Steven D. Macht
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impaired responsiveness of the ventricular sensory receptor in hypertensive patients with left ventricular hypertrophy.
Authors: B Trimarco, N De Luca, B Ricciardelli, A Cuocolo, A De Simone, M Volpe, A F Mele, M Condorelli
Journal: Circulation (1986)

We studied the control of forearm vascular resistance (FVR) by cardiopulmonary receptors in seven patients with hypertension and left ventricular hypertrophy (LVH) and in seven normotensive control subjects. Increasing levels of lower body negative pressure (LBNP) (-10 and -40 mm Hg) induced a progressive decrease in central venous pressure (CVP) and an increase in FVR. The changes in these two variables were correlated both in normal subjects and patients with hypertension (slope for normal subjects = -29.9, for patients with hypertension = -40.3, NS). After propranolol, there was a significant reduction in the increase in FVR induced by -40 mm Hg LBNP in normal subjects (+107 +/- 5 vs +129 +/- 15 mm Hg/ml/sec, p less than .05) but not in patients with hypertension. Consequently, the slope of the delta CVP/delta FVR regression was reduced in normal subjects (-20.6, p less than .01) but not in patients with hypertension. In another seven normal subjects and seven patients with hypertension and LVH we assessed the effects of -10 and -40 mm Hg LBNP on left ventricular filling pressure (LVFP). LBNP induced similar changes in CVP, LVFP, and total peripheral resistance both in normal subjects and in patients with hypertension. Propranolol failed to modify the effects of LBNP on CVP and LVFP in both groups and reduced the response of total peripheral resistance to -40 mm Hg LBNP only in normal subjects. Propranolol did not reduce the response of FVR to the cold pressor test and sustained handgrip or the arterial baroreflex response to the injection of phenylephrine and increased neck tissue pressure. Thus, hypertension-induced LVH seems to be associated with a selective impairment of the left ventricular sensory receptors.
Adair Stuart Mason
Authors: D. Worsfold
Journal: BMJ (2003)

Stuart Mason did much in the 1960s and 1970s to promote modern concepts of doctor-patient communication. A great communicator and a gifted writer, he founded the Journal of the Royal College of Physicians in 1966, which he edited for 21 years, and was a regular contributor to World Medicine during its agenda setting heyday in the 1970s. After his retirement, he turned his talent for research and writing to the world of local history, in particular of Essex and of maps, winning prizes for his writing.​writing.




Figure 1




He was on duty as a casualty officer at the London Hospital on the night of the Bethnal Green disaster in March 1943 when 173 people died in a crush to get down to the safety of the shelters on the tube station platforms during an air raid. Following graduation, he served with the Royal Army Medical Corps in India for three years.

In 1950 he became consultant endocrinologist at Oldchurch Hospital, Romford. He went on to build up the endocrine unit at the London Hospital, returning to the medical college there first as a lecturer, then senior lecturer, achieving consultant status in 1959. His extensive academic writing included Introduction to Endocrinology (1957) and Endocrinology (1960), and he co-edited the 16th and 17th editions of Hutchinson's Clinical Methods. He also wanted the wider public to have a better understanding of endocrinology and wrote two popular Penguin paperbacks, Health and Hormones (1960) and Hormones and the Body (1976).

In addition to the RCP journal, he founded Clinical Endocrinology in 1972, and as honorary editor of the Journal of the Royal Society of Medicine from 1976 to 1979 he completely revamped a tired publication.

His appetite for research and writing found a new outlet after retirement when he combined his love of maps with a devotion to the local history of Essex. In 1990 the Essex Records Office published his book Essex on the Map. In 1999 he won the inaugural Local History Award for an article on summer camps for soldiers in Essex 1778-82.

He leaves a wife, Rosemary; four children; and 11 grandchildren.

Adair Stuart Mason, former endocrinologist the London Hospital (b 1919;q Cambridge/London 1943; MRCP, MD), d 25 August 2003.
US medical students in Cuba receive temporary reprieve
Authors: Jeanne Lenzer
Journal: BMJ (2004)

A controversial new policy that threatened to force 80 medical students from poor areas of the United States who are studying in Cuba to leave the island has been suspended.

The policy was met with a barrage of protests. Congresswoman Barbara Lee and 27 members of Congress sent a letter to Secretary of State Colin Powell on 23 June stating that the medical students “have pledged to return to their respective communities and offer low cost health care to those who cannot afford it.” They added …
REPLACEMENT FIBROSIS DETECTED BY CMR IS A PREDICTOR OF OUTCOME IN PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY
Authors: Mohamad Ghosn, Itamar Birnbaum, Kongkiat Chaikriangkrai, Arvind Bhimaraj, Barry Trachtenberg, Guillermo Torre-Amione, Jerry Estep, Dipan Shah
Journal: Journal of the American College of Cardiology (2014)
Mapping of the hypokalaemic periodic paralysis (HypoPP) locus to chromosome 1q31–32 in three European families
Authors: B. Fontaine, J. Vale-Santos, K. Jurkat-Rott, J. Reboul, E. Plassart, C-S. Rime, A. Elbaz, R. Heine, J. Guimarães, J. Weissenbach, N. Baumann, M. Fardeau, F. Lehmann-Horn
Journal: Nature Genetics (1994)
Cardiac Perforation Following Left Ventricular Cineangiocardiography
Authors: AARON R. LEVIN, MADISON S. SPACH, PAGE A. W. ANDERSON, M. PAUL CAPP
Journal: Circulation (1965)

A case of perforation of the left ventricle during selective cineangiocardiography in a 27-month-old child with aortic stenosis is reported. Perforation was visualized during the power injection, and subsequent cardiac tamponade developed. Immediate pericardiocentesis resulted in rapid improvement and the child made an uneventful recovery. At cardiac surgery for aortic valvotomy 5 days later no abnormalities of the pericardium were noted but there was a small area of discoloration on the posterior left ventricular free wall. Prevention of poor catheter positioning is suggested as the major preventive measure to avoid such complications during selective ventricular angiocardiography.
Nelson's Syndrome
Authors: J. L. Gabrilove, G. L. Nicolis
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 May 1977Nelson's SyndromeJ. L. GABRILOVE, M.D., G. L. NICOLIS, M.D., PH.D.J. L. GABRILOVE, M.D.Search for more papers by this author, G. L. NICOLIS, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-5-665_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: From their study of Nelson's syndrome Moore and colleagues (1) reported nine patients with the disorder out of 120 patients treated for Cushing's syndrome. Of these nine only two had received prior pituitary irradiation; one having received 3000 rad, the other 5000. They cite a case from Salassa's and associates' series of pituitary tumors in patients with Cushing's syndrome who was reported without comment to have developed a pituitary tumor subsequent to pituitary irradiation with 2400 rad and bilateral subtotal adrenalectomy. Most radiotherapists would consider that dosages of 2400 to 3000 rad to the pituitary at the...References1. MOOREDLUHYWILLIAMS TRG: Nelson's syndrome: frequency, prognosis and effect of prior pituitary irradiation. Ann Intern Med 85:731-734, 1976 LinkGoogle Scholar2. ORTHLIDDLE DG: Results of treatment in 108 patients with Cushing's syndrome. N Engl J Med 285:243, 1971 CrossrefMedlineGoogle Scholar3. WILDNICOLISGABRILOVE WGJ: Appearance of Nelson's syndrome despite pituitary irradiation prior to bilateral adrenalectomy for Cushing's syndrome. M Sinai J Med NY 40:68, 1973 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. L. GABRILOVE, M.D.; G. L. NICOLIS, M.D., PH.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1977Volume 86, Issue 5Page: 665-665KeywordsAdrenalectomyPituitary tumors ePublished: 1 December 2008 Issue Published: 1 May 1977 PDF downloadLoading ...
Depression and Advanced Complications of Diabetes
Authors: Elizabeth H.B. Lin, Carolyn M. Rutter, Wayne Katon, Susan R. Heckbert, Paul Ciechanowski, Malia M. Oliver, Evette J. Ludman, Bessie A. Young, Lisa H. Williams, David K. McCulloch, Michael Von Korff
Journal: Diabetes Care (2009)

OBJECTIVE To prospectively examine the association of depression with risks for advanced macrovascular and microvascular complications among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS A longitudinal cohort of 4,623 primary care patients with type 2 diabetes was enrolled in 2000–2002 and followed through 2005–2007. Advanced microvascular complications included blindness, end-stage renal disease, amputations, and renal failure deaths. Advanced macrovascular complications included myocardial infarction, stroke, cardiovascular procedures, and deaths. Medical record review, ICD-9 diagnostic and procedural codes, and death certificate data were used to ascertain outcomes in the 5-year follow-up. Proportional hazard models analyzed the association between baseline depression and risks of adverse outcomes. RESULTS After adjustment for prior complications and demographic, clinical, and diabetes self-care variables, major depression was associated with significantly higher risks of adverse microvascular outcomes (hazard ratio 1.36 [95% CI 1.05–1.75]) and adverse macrovascular outcomes (1.24 [1.0–1.54]). CONCLUSIONS Among people with type 2 diabetes, major depression is associated with an increased risk of clinically significant microvascular and macrovascular complications over the ensuing 5 years, even after adjusting for diabetes severity and self-care activities. Clinical and public health significance of these findings rises as the incidence of type 2 diabetes soars. Further research is needed to clarify the underlying mechanisms for this association and to test interventions to reduce the risk of diabetes complications among patients with comorbid depression.
PTH-104 Diagnostic Yield Of Secretin Enhanced Mrcp In The Investigation Of Patients With Acalculous Pancraetico-biliary Type Abdominal Pain: Abstract PTH-104 Table 1
Authors: SS Dronamraju, J Scott, K Oppong, RM Charnley, M Nayar
Journal: Gut (2014)

<h3>Introduction</h3> Secretin enhanced magnetic resonance cholangio-pancreatography (S-MRCP) has been used as part of the diagnostic algorithm for the diagnosis of patients presenting with acalculous biliary type abdominal pain (ABAP); the exact role of this diagnostic modality is unclear. The aim of this study was to assess the diagnostic yield of S-MRCP in a large HPB tertiary referral centre in the investigation of patients with ABAP. <h3>Methods</h3> Retrospective analysis of a prospectively maintained database of all patients presenting with ABAP in whom a S-MRCP was requested from June 2008 to May 2013. The findings of S-MRCP were compared with those of MRCP and EUS (performed prior to S MRCP) and the diagnostic yield of S-MRCP in the work up of a patient presenting with ABAP was estimated. <h3>Results</h3> Of the 117 patients with ABAP [28 males and 89 female; mean age 48 yrs] were referred for S-MRCP, 114 (97.4%) patients successfully completed the scan. Of these 37 patients who had a normal MRCP, S-MRCP identified significant findings in 8 (22%) patients (Table 1). In the present study 78 (67%) patients had EUS. Out of the 41 patients who had a normal EUS, S-MRCP was able to identify significant pathology in 21 (54%) patients (Table 1). <h3>Conclusion</h3> This study suggests that S-MRCP has a 22 and 54% additional diagnostic yield in ABAP patients who have a normal MRCP and a normal EUS respectively. The commonest abnormality identified in these patients on S-MRCP was obstruction at ampulla or proximal PD. S-MRCP should be considered in the diagnostic algorithm of patients with ABAP. <h3>References</h3> 1 Mariani A, Arcidiacono PG, Curioni S, <i>et al</i>. Diagnostic yield of ERCP and secretin-enhanced MRCP and EUS in patients with acute recurrent pancreatitis of unknown aetiology. <i>Dig Liver Dis</i> 2009 Oct;41(10):753-8 2 Matos C, Metens T, Devière J, <i>et al</i>. Pancreas divisum: evaluation with secretin-enhanced magnetic resonance cholangiopancreatography. <i>Gastrointest Endosc</i> 2001 Jun;53(7):728-33 <h3>Disclosure of Interest</h3> None Declared.
An approach to management of critical indoor air problems in school buildings.
Authors: U Haverinen, T Husman, M Toivola, J Suonketo, M Pentti, R Lindberg, J Leinonen, A Hyvärinen, T Meklin, A Nevalainen
Journal: Environmental Health Perspectives (1999)

This study was conducted in a school center that had been the focus of intense public concern over 2 years because of suspected mold and health problems. Because several attempts to find solutions to the problem within the community were not satisfactory, outside specialists were needed for support in solving the problem. The study group consisted of experts in civil engineering, indoor mycology, and epidemiology. The studies were conducted in close cooperation with the city administration. Structures at risk were opened, moisture and temperature were measured, and the causes of damage were analyzed. Microbial samples were taken from the air, surfaces, and materials. Health questionnaires were sent to the schoolchildren and personnel. Information on the measurements and their results was released regularly to school employees, students and their parents, and to the media. Repairs were designed on the basis of this information. Moisture damage was caused mainly by difficult moisture conditions at the building site, poor ventilation, and water leaks. Fungal genera (concentrations <200 colony-forming units (cfu)/m(3), <3000 cfu/cm(2)) typical to buildings with mold problems (e.g., Aspergillus versicolor, Eurotium) were collected from the indoor air and surfaces of the school buildings. Where moisture-prone structures were identified and visible signs of damage or elevated moisture content were recorded, the numbers of microbes also were high; thus microbial results from material samples supported the conclusions made in the structural studies. Several irritative and recurrent symptoms were common among the upper secondary and high school students. The prevalence of asthma was high (13%) among the upper secondary school students. During the last 4 years, the incidence of asthma was 3-fold that of the previous 4-year period.
Are Medical Education and Research Being Overfunded?
Authors: Maurice B. Visscher
Journal: JAMA (1971)

To the Editor.—  In a time of economic stringency public fiscal officers look for ways of saving money without causing too much public dissatisfaction or too many political problems. With the retirement of Sen Lister Hill and the death of Cong John Fogarty, the political hazard to the White House in reducing funding for medical research and education was greatly diminished. It is probably no accident that the serious setback to federal funding of these enterprises occurred at the time that those powerful protagonists for medical research and education were lost to the cause. The void that was created points up the need for greater public understanding of the proper and necessary role of research and education in the delivery of health care and in future improvements in such care to the public interest. In fact, there is even need for better understanding by a minority of the medical profession
Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor
Authors: I VILLAR, C PANAYIOTOU, A SHERAZ, M MADHANI, R SCOTLAND, M NOBLES, B KEMPHARPER, A AHLUWALIA, A HOBBS
Journal: Cardiovascular Research (2007)

Objective: C-type natriuretic peptide (CNP) has recently been suggested to represent an endothelium-derived hyperpolarising factor (EDHF) in the mammalian resistance vasculature and, as such, important in the regulation of local blood flow and systemic blood pressure. Additionally, this peptide has been shown to protect against ischaemia–reperfusion injury and inhibits leukocyte and platelet activation. Herein, we use a novel, selective natriuretic peptide receptor-C (NPR-C) antagonist (M372049) to highlight the pivotal contribution of CNP/NPR-C signalling in the EDHF-dependent regulation of vascular tone and investigate the mechanism(s) underlying the release and biological activity of CNP.