tbuckley/cabot-search huggingface dataset:
1966 revisited: bright new contract or brave old world?
Authors: S Iliffe
Journal: BMJ (1993)

<h3>ABSTRACT</h3> Red blood cells (RBCs) must be highly deformable to transit through the microvasculature to deliver oxygen to tissues. The loss of RBC deformability resulting from pathology, natural aging, or storage in blood bags can impede the proper function of these cells. A variety of methods have been developed to measure RBC deformability, but these methods require specialized equipment, long measurement time, and highly skilled personnel. To address this challenge, we investigated whether a machine learning approach could be applied to determine donor RBC deformability using single cell microscope images. We used the microfluidic ratchet device to sort RBCs based on deformability. Sorted cells are then imaged and used to train a deep learning model to classify RBCs based on deformability. This model correctly predicted deformability of individual RBCs with 84 ± 11% accuracy averaged across ten donors. Using this model to score the deformability of RBC samples were accurate to within 4.4 ± 2.5% of the value obtained using the microfluidic ratchet device. While machine learning methods are frequently developed to automate human image analysis, our study is remarkable in showing that deep learning of single cell microscopy images could be used to measure RBC deformability, a property not normally measurable by imaging. Measuring RBC deformability by imaging is also desirable because it can be performed rapidly using a standard microscopy system, potentially enabling RBC deformability studies to be performed as part of routine clinical assessments.
THE TECHNIC OF CATHETERISM OF THE EUSTACHIAN TUBE, AND THE INDICATIONS FOR ITS USE.A Clinical Lecture delivered at the Chicago Policlinic, August 2, 1892
Authors: JOHN F. OAKS
Journal: JAMA (1893)

By catheterism of the Eustachian tube we understand the introduction of a properly curved tube into the tubal orifice, from 5 to 15 mm. according to the depth of the trumpet shaped opening of the pharyngeal orifice of the Eustachian tube. Since our time is limited and you can readily find in your text books the historical details of this procedure, I will at once enter<i>in medias res</i>. The necessary instruments for the proper performance of eustachian catheterization are, 1, the catheter; 2, the auscultation tube sometimes improperly called the otoscope and 3, the air bag. Eustachian catheters are made of hard and soft rubber and of silver. Hard rubber catheters have the advantage of cheapness and lightness; they are not easily corroded. The aurist can supply himself with a number of all sizes and curves, so that each patient may have one to himself and thus escape the
Chronic Respiratory Alkalosis
Authors: Reto Krapf, Iris Beeler, Daniel Hertner, Henry N. Hulter
Journal: New England Journal of Medicine (1991)

In normal subjects, chronic hyperventilation lowers plasma bicarbonate concentration, primarily by inhibiting the urinary excretion of net acid. The quantitative relation between reduced arterial carbon dioxide tension (PaCO2) and the plasma bicarbonate concentration in the chronic steady state has not been studied in humans, however, and the laboratory criteria for the diagnosis of chronic respiratory alkalosis therefore remain undefined. We wished to provide such reference data for clinical use. Moreover, because chronic hyperventilation paradoxically lowers blood pH still further in dogs with metabolic acidosis, we desired to study the effect of chronic hypocapnia on the plasma bicarbonate concentration (and blood pH) in normal human subjects in whom acidosis had been induced with ammonium chloride.
There is no evidence that...
Authors: K. Barraclough
Journal: BMJ (2003)

I was in a medical meeting discussing the extent to which mental attitude influences the natural history of disease. In an interesting debate the mantra “there is no evidence that…” was repeated at diverse moments by several colleagues. Although I am an enthusiast of evidence based medicine I must admit that I have begun to find it irritating that the phrase is used like some sort of runic spell to negate all opposition. Surely it encompasses two …
Understanding How Cutaneous Lupus Erythematosus Progresses to Systemic Lupus Erythematosus
Authors: Benjamin F. Chong
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
CD3‐negative, CD20‐positive T‐cell prolymphocytic leukemia: Case report and review of the literature
Authors: Kenji Tamayose, Naotake Sato, Jun Ando, Koichi Sugimoto, Kazuo Oshimi
Journal: American Journal of Hematology (2002)

Abstract We report a case of CD3‐negative, CD20‐positive T‐cell prolymphocytic leukemia (T‐PLL). The leukemic cells were of medium‐to‐large size, mature‐looking, and did not have cytoplasmic granules. The leukemic cells were negative for surface CD3, CD2, and CD7 and strongly positive for CD20. T‐cell lineage markers such as CD4, CD5, and cytoplasmic CD3 were also positive. A monoclonal rearrangement of the T‐cell receptor (TCR) β chain gene was detected. CD3‐negative T‐PLL has been reported often, but CD20‐positive T‐PLL has not. We reviewed seven cases of CD20‐positive immature and mature T‐cell leukemias, including the present case. Three were immature T‐cell leukemias (acute lymphoblastic leukemia), and four were mature T‐cell leukemias (granular lymphocytic leukemia, small lymphocytic lymphoma/chronic lymphocytic leukemia, adult T‐cell leukemia, and the present case). Splenomegaly was a common feature. However, our case alone had “bright” CD20 expression on the leukemic cells. This is the first report of CD20 + T‐PLL. Am. J. Hematol. 71:331–335, 2002. © 2002 Wiley‐Liss, Inc.
NIH Program Helps Developers Navigate Path to New Drugs for Neglected Diseases
Authors: Rebecca Voelker
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short-term Results of a Magnetic Resonance Imaging–Based Swedish Screening Program for Individuals at Risk for Pancreatic Cancer
Authors: Marco Del Chiaro, Caroline S. Verbeke, Nikolaos Kartalis, Raffaella Pozzi Mucelli, Peter Gustafsson, Johan Hansson, Stephan L. Haas, Ralf Segersvärd, Åke Andren-Sandberg, J.-Matthias Löhr
Journal: JAMA Surgery (2015)

Pancreatic cancer is the fourth leading cause of cancer-related death in Western countries. In approximately 10% of all patients with pancreatic cancer, it is possible to define a positive family history for pancreatic cancer or for one of the other related genetic syndromes. A screening program for individuals at risk is recommended; however, surveillance modalities have not been defined yet.To analyze the short-term results of a prospective clinical surveillance program for individuals at risk for pancreatic cancer using a noninvasive magnetic resonance imaging (MRI)-based screening protocol.A prospective observational study of all patients with a genetic risk for developing pancreatic cancer who were referred to Karolinska University Hospital between January 1, 2010, and January 31, 2013, using an MRI-based surveillance program. All patients were investigated for the most common genetic mutations associated with pancreatic cancer.A noninvasive MRI-based screening protocol.The ability of MRI to identify potential precancerous or early cancers in individuals at risk for pancreatic cancer.Forty patients (24 women and 16 men) were enrolled. The mean age was 49.9 years. The mean length of follow-up was 12.9 months. The numbers of relatives affected by pancreatic cancer were 5 in 2 patients (5%), 4 in 5 patients (12.5%), 3 in 17 patients (42.5%), 2 in 14 patients (35%), and 1 in 2 patients (5%). In 4 patients (10%), a p16 mutation was found; in 3, a BRCA2 mutation (7.5%); and in 1, a BRCA1 mutation (2.5%). In 16 patients (40%), MRI revealed a pancreatic lesion: intraductal papillary mucinous neoplasia (14 patients, 35%) and pancreatic ductal adenocarcinoma (2 patients, 5%). One patient had a synchronous intraductal papillary mucinous neoplasia and pancreatic ductal adenocarcinoma. Five patients (12.5%) required surgery (3 for pancreatic ductal adenocarcinoma and 2 for intraductal papillary mucinous neoplasia), while the remaining 35 are under continued surveillance.During a median follow-up of approximately 1 year, pancreatic lesions were detected in 40% of the patients, of whom 5 underwent surgery. Although the study time was relatively short, the surveillance program in individuals at risk seems to be effective.
Serum levels of interleukin 6 and of interleukin 6 receptor in patients with hepatocellular carcinoma
Authors: L. Giannitrapani, G. Montalto, M. Notarbartolo, L. Virruso, M. Soresi, A. Carroccio, N. D'Alessandro, M. Cervello
Journal: Journal of Hepatology (2001)
Low molecular weight heparin in prevention of perioperative thrombosis.
Authors: A. Leizorovicz, M. C. Haugh, F. R. Chapuis, M. M. Samama, J. P. Boissel
Journal: BMJ (1992)

OBJECTIVE--To determine whether prophylactic treatment with low molecular weight heparin reduces the incidence of thrombosis in patients who have had general or orthopaedic surgery. DESIGN--Meta-analysis of results from 52 randomised, controlled clinical studies (29 in general surgery and 23 in orthopaedic surgery) in which low molecular weight heparin was compared with placebo, dextran, or unfractionated heparin. SUBJECTS--Patients who had had general or orthopaedic surgery. INTERVENTION--Once daily injection of a low molecular weight heparin compared with placebo, dextran, or unfractionated heparin. MAIN OUTCOME MEASURES--Incidence of deep venous thrombosis, pulmonary embolism, major haemorrhages, and death. RESULTS--The results confirm that low molecular weight heparins are more efficacious for the prophylactic treatment of deep venous thrombosis than placebo (common odds ratio 0.31, 95% confidence interval 0.22 to 0.43; p &lt; 0.001) and dextran (0.44, 0.30 to 0.65; p &lt; 0.001). The results suggest that low molecular weight heparins are also more efficacious than unfractionated heparin (0.85, 0.74 to 0.97; p = 0.02), with no significant difference in the incidence of major haemorrhages (1.06, 0.93 to 1.20; p = 0.62). CONCLUSIONS--Low molecular weight heparins seem to have a higher benefit to risk ratio than unfractionated heparin in preventing perioperative thrombosis. However, it remains to be shown in a suitably powered clinical trial whether low molecular weight heparin reduces the risk of fatal pulmonary embolism compared with heparin.
Absence of role of endothelium in the response of isolated porcine coronary arteries to acetylcholine
Authors: T. GRASER, H. LEISNER, N. TIEDT
Journal: Cardiovascular Research (1986)

Isolated precontracted arteries of various vascular beds relax in response to acetylcholine only if the endothelium is present. One explanation for this is that this drug stimulates the endothelial cells to release a vasodilator substance that in turn relaxes the underlying smooth muscle. To determine whether this mechanism is concerned also in the acetylcholine contraction of isolated porcine coronary arteries transverse strips of the extramural part of the left circumflex artery were used for recording isometric tension in the muscle bath. Dose-response curves for acetylcholine showed no significant difference before and after removal of endothelium. As a functional check on the removal of endothelium, the responsiveness of each preparation to a known endothelium dependent dilator (substance P) was tested before and after removal. These findings suggest that endothelial cells are not concerned in the acetylcholine induced contraction of porcine coronary arteries. Acetylcholine appears to act directly on smooth muscle of the porcine artery.
The WHO Multinational Study of Vascular Disease in Diabetes: 3. Microvascular Disease
Authors: R J Jarrett, H Keen
Journal: Diabetes Care (1979)

A preliminary comparison and analysis of microvascular disease was performed in 14 stratified samples of diabetic subjects. Microvascular disease was assessed by estimating visual disabilities, by standardized examination of the optic fundus by direct ophthalmoscopy, by estimating proteinuria, and by measuring the serum creatinine concentration. Visual impairment by questionnaire positive varied considerably between centers, probably due to cultural differences in interpretation of the questions. Physician-assessed visual disability also yielded considerable differences in frequency; however, the frequency differences were unrelated to those observed for macrovascular disease. Retinopathy--the sum of all components--was related to duration of diabetes in each participating center. The apparent frequency of proteinuria varied considerably between centers. In general, the frequency of retinopathy was related to the level of systolic blood pressure, but there was no systematic association with cigarette smoking.
Cephalic phase of colonic pressure response to food.
Authors: J Rogers, A H Raimundo, J J Misiewicz
Journal: Gut (1993)

A cephalic phase of colonic pressure response to food was sought in five normal subjects (mean age (22.6) years, 22-24), studied on six separate occasions by recording intraluminal pressures in the unprepared sigmoid colon. Gastric acid secretion was measured simultaneously by continuous aspiration through a nasogastric tube. After a 60 minute basal period, one of five 30 minute food related cephalic stimuli, or a control stimulus was given in random order; records were continued for a further 120 minutes. The cephalic stimuli were: food discussion, sight and smell of food without taste, smell of food without sight or taste, sight of food without smell or taste, and modified sham feeding; the control stimulus was a discussion of neutral topics. Colonic pressures were expressed as study segment activity index (area under curve, mm Hg.min) derived by fully automated computer analysis. Gastric acid output was expressed as mmol/30 min. Food discussion significantly (p &lt; 0.02, Wilcoxon9s rank sum test) increased colonic pressure activity compared with control or basal activity. Smell of food without sight or taste also significantly (p &lt; 0.03) increased the colonic pressure activity compared with control and basal periods. Sham feeding and sight and smell of food without taste significantly (p &lt; 0.02 and p &lt; 0.03) increased colonic pressures compared with control but not basal activity. The increase in colonic activity after sight of food without smell or taste was not significantly different from control or basal activity (p = 0.44 and p = 0.34). Food discussion was the strongest colonic stimulus tested. Food discussion and sham feeding significantly (p&lt;0.02) stimulated gastric acid output above control and basal values. Sight and smell of food without taste significantly (p&lt;0.02) increased acid output above basal. Smell of food without sight or taste and sight of food without smell or taste did not significantly (p=0.06, p=0.34) increase acid output. In contrast with the effect on colonic pressures, sham feeding was the best stimulus of acid output. Increased colonic pressure activity after food discussion correlated significantly (r=0.45, p&lt;0.02) with gastric acid output. There was no correlation (r=-0.1, p&gt;0.5) between colonic pressure activity and gastric acid output in the control study. These data show that there is a cephalic phase of the colonic response to food.
Familial Right Bundle-Branch Block, Left Axis Deviation, Complete Heart Block, and Early Death
Authors: Stephen F. Schaal, John Seidensticker, Richard Goodman, Charles F. Wooley
Journal: Annals of Internal Medicine (1973)

A patient with right bundle-branch block and left axis deviation who later developed complete heart block had a family history suggestive of familial bundle-branch disease and heart block. Investigation of 59 members in four generations of the family showed 26 with abnormal electrocardiograms and 6 with a history of heart block. Seven have right bundle-branch block and left axis deviation; seven have right bundle-branch block, left axis deviation, and intermittent complete heart block. All affected members have conduction abnormalities as the only manifestation of heart disease. The genetic defect appears to be transmitted as an autosomal dominant trait with varying expressivity. This conduction abnormality, not recognized as a heritable disorder, raises questions about the development of the ischemic or degenerative processes thought important in this disease. Additional family studies of individuals with conduction system disease are needed.
Clearing of psoriasis after cardiac surgery requiring cardiopulmonary bypass oxygenation: a corollary to clearance after dialysis?
Authors: T. J. BUSELMEIER, J.S. CANTIERI, M.V. DAHL, R.S. NELSON, J.C. BAUMGAERTNER, C.R. BENTLEY, R.W. GOLTZ
Journal: British Journal of Dermatology (1979)

A 54-year-old man had severe psoriasis with associated arthritis for 10 years. Attempts at therapy with tars, topical steroids and a short course of ultraviolet light were unsuccessful. His psoriasis cleared 6 weeks after cardiac surgery requiring cadiopulmonary bypass oxygenation.
High—Monounsaturated Fat Diet for Diabetic Patients: Is it time to change the current dietary recommendations?
Authors: Abhimanyu Garg
Journal: Diabetes Care (1994)

The study by Rasmussen et al. (1) and studies by Campbell et al. (2, this issue) and Lerman-Garber et al. (3, this issue) report on the beneficial effects of high-monounsamrated fat diets in comparison with high-carbohydrate diets in patients with non-insulin-dependent diabetes mellims (N1DDM). The study by Rasmussen et al. (1) reported improvement of glycemie control and lowering of blood pressure (BP) with a high-monounsaturated fat diet. Campbell et al. (2) describe practical ways to prescribe a high-monounsaturated fat diet to NIDDM patients for use at home and report improvement in glycemie control and plasma triglyceride levels. Lerman-Garber et al. (3) report lowering of plasma triglyceride levels with an avocado-based high-monounsaturated fat diet. These data generally confirm the results of previous studies (4-9) and further support the use of high-monounsaturated fat diets in diabetic patients.
Depression and Leucotomy
Authors: W. W. Sargant
Journal: BMJ (1966)

If, rightly or wrongly, one accepts the theory that intrauterine devices, both ancient and modem, act as disnidators, then they are not contraceptives but abortifacients, and the incidence of extrauterine gestations in those women who have been fitted with these devices should remain unaffected.Mr. Ramkissoon-Chen and Dr. Kong Ta-Ko have issued a timely warning that in these cases the symptoms produced by a tubal gestation may easily be mistaken for side- effects due to the intrauterine device.In underlining this warning I hope that the diagnostic pitfall will be widely appreciated in order that occasional serious complications may be avoided.-Iam, etc.,
Infarction in Patients Treated With Propranolol
Authors: J. F. Pantridge
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The Figure represents the findings in the angiogram of a patient discharged on a drug regimen for angina pectoris from a hospital in the United States. The right coronary artery showed high-grade obstruction at the usual site of obstruction, just proximal to the origin of the branch to the atrioventricular node. It is not unreasonable to suppose that in such a situation there exists a high risk of complete obstruction and consequent acute myocardial infarction. It may, therefore, be salutary to consider the immediate effects of acute occlusion. Observations on 21 patients within 30 minutes of the onset of posterior infarction when this was a first infarct showed that 17 had bradycardia, 16 with associated hypotension. Eight of the 17 had a systolic blood pressure not greater than 80 mm Hg, and in two patients the blood pressure was unrecordable. Thus, eight of the 21, or one
Poor sales signal shake-up in Hungary s health insurance market
Authors: C. Kovac
Journal: BMJ (2001)

While one of Hungary's top insurers is pulling out of the healthcare insurance market, another is staking a claim in the sector in anticipation of healthcare reforms expected after next year's national elections.

Hungaria Insurance, the country's largest insurance company issuing policies other than life insurance, is no longer issuing health insurance policies, citing poor sales and a surge in claims.

“Hungaria won't cancel its existing contracts but won't sign new ones either,” said Mihaly Patai, the company's chief executive officer.

Hungaria commanded 20% of the annual health insurance market—worth …
ETV6-NTRK3 Fusion Oncogene Initiates Breast Cancer from Committed Mammary Progenitors via Activation of AP1 Complex
Authors: Zhe Li, Cristina E. Tognon, Frank J. Godinho, Laura Yasaitis, Hanno Hock, Jason I. Herschkowitz, Chris L. Lannon, Eunah Cho, Seong-Jin Kim, Roderick T. Bronson, Charles M. Perou, Poul H. Sorensen, Stuart H. Orkin
Journal: Cancer Cell (2007)