tbuckley/cabot-search huggingface dataset:
The use of microgel iron oxide nanoparticles in studies of magnetic resonance relaxation and endothelial progenitor cell labelling
Authors: Eddy S.M. Lee, Borys Shuter, Jerry Chan, Mark S.K. Chong, Jun Ding, Swee-Hin Teoh, Olivier Beuf, André Briguet, Kam Chiu Tam, Mahesh Choolani, Shih-Chang Wang
Journal: Biomaterials (2010)
Seventy five years of arthritis research at the Strangeways Research Laboratory: 1912-87.
Authors: J T Dingle
Journal: Annals of the Rheumatic Diseases (1987)

<h3>ABSTRACT:</h3> Nitrate contamination of shallow groundwater has been widely documented in association with agriculture in the Coastal Plain region of the Chesapeake Bay watershed. Elevated groundwater nitrate levels limit the use of shallow groundwater for human consumption and also result in elevated nonpoint source nitrogen (N) loads to Chesapeake Bay via elevated stream base-flow nitrate concentrations. This study investigated the effects of cereal grain winter cover crops on nitrate leaching rates, profile nitrate storage, and nitrate concentrations in shallow groundwater in two field-scale watersheds planted continuously in corn (Zea mays L) from 1984 through 1996. Winter-fallow conditions were maintained following the 1984 through 1987 growing seasons and cereal rye (Secale cereale L.) as a cover crop was planted immediately after grain harvest from 1988 through 1996. Cover crop effects on nitrate leaching rates also were evaluated in continuous no-till corn plots from 1990 through 1995. Nitrate leaching losses from the root zone and recharge of ‘shallow aquifers occurred primarily during winter months under conditions of law evapotranspiration’. The potential for nitrate leaching losses was determined primarily by the availability of nitrate in the root zone at the onset of the winter groundwater recharge period. Rye winter cover crops planted after corn harvest consistently reduced nitrate-N concentrations in root zone leachate to less than 1 mg/L during most of the groundwater recharge period, and reduced annual nitrate leaching losses by approximately 80% relative to winter-fallow treatments. Shallow groundwater nitrate-N concentrations under long-term continuous corn production decreased from the 10 to 20 mg/L range to less than 5 mg/L after seven years of cover crop use. Cover crops appeared to increase corn yields under adverse growing season conditions, but limited residual nitrate availability during the growing season relative to winter-fallow settings. Cover crop growth was generally N limited, suggesting that increased N inputs would have little effect on nitrate leaching, but would increase cover crop contributions to soil carbon pools.
Biochemical Evidence of Anxiety in Dental Patients
Authors: H. D. Edmondson, B. Roscoe, M. D. Vickers
Journal: BMJ (1972)

Urinary metabolites before dental treatment were compared in a group of patients with dental phobia and in a matched control group. Plasma adrenaline, noradrenaline, and free fatty acids were estimated before treatment, immediately after sedation with diazapam 0.2 mg/kg body weight in the phobic patients, during induction of oral anaesthesia, and during and after surgery. Patients with dental phobia had significantly higher levels of adrenaline, which were only temporarily lowered by sedation, and which during treatment remained consistently higher than those of control patients.
Trimethoprim-Sulfamethoxazole: Pharmacodynamic Effects of Urinary pH and Impaired Renal Function
Authors: WILLIAM A. CRAIG
Journal: Annals of Internal Medicine (1973)

Trimethoprim-sulfamethoxazole therapy was studied in persons with normal and impaired renal function, who were given a single oral dose of the combined drug. Oral acid loading increased the quantitative recovery of trimethoprim in urine but had no effect on urinary recovery of nonacetylated sulfamethoxazole. In contrast, alkali loading increased the urinary recovery of nonacetylated sulfamethoxazole and decreased the recovery of trimethoprim. The ratio of urinary concentration of sulfamethoxazole to trimethoprim was dependent on urine pH. A single dose of the combined drugs in uremic patients was associated with a prolonged half-life in blood and reduced quantitative recovery in urine for both drugs. The serum protein binding of sulfamethoxazole but not trimethoprim was reduced in uremic patients. Concentrations of both drugs in the urine of uremic patients seemed adequate for most susceptible urinary tract organisms. Trimethoprim-sulfamethoxazole may be useful for treating urinary infections in uremic patients.
Aerobic and anaerobic power responses to the practice of taekwon-do
Authors: A F Melhim
Journal: British Journal of Sports Medicine (2001)

Practising the martial art of taekwon-do (TKD) has been proposed to have beneficial effects on cardiovascular fitness as well as general physical ability. Furthermore, TKD masters and participants have promoted TKD as a total fitness programme. Research studies substantiating this, however, seem to be lacking, perhaps because TKD is recognised more as a method of self defence than a fitness programme.Nineteen TKD practitioners with an average age of 13.8 years and 10.4 months of TKD training experience were recruited to participate. Measurements included resting heart rate, aerobic power, anaerobic power, and anaerobic capacity.Paired t test analysis showed no significant differences in either resting heart rate or aerobic power after training. However, significant differences were observed in anaerobic power and anaerobic capacity (p = 0.05). The increases in anaerobic power and anaerobic capacity were 28% and 61.5% respectively.The practice of TKD promotes anaerobic power and anaerobic capacity, but not aerobic power, in male adolescents.
SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications
Authors: F Damm, F Thol, O Kosmider, S Kade, P Löffeld, F Dreyfus, A Stamatoullas-Bastard, A Tanguy-Schmidt, O Beyne-Rauzy, S de Botton, A Guerci-Bresler, G Göhring, B Schlegelberger, A Ganser, O A Bernard, M Fontenay, M Heuser
Journal: Leukemia (2011)
One Day Diagnosis and Treatment of Hyperthyroidism.
Authors: M L. Nusynowitz
Journal: Clinical Nuclear Medicine (2006)

Scientific Abstracts: Nine Poster Presentations for the 51st Annual Meeting of the Southwestern Chapter of the Society of Nuclear Medicine April 7-9, 2006, Hyatt Regency, Albuquerque, New Mexico http: //www.swcsnm.org: PDF Only
Identification of T cell lymphoma tumor antigens on human T cell lines
Authors: Joseph Kaplan, Jerel Tilton, Ward D. Peterson
Journal: American Journal of Hematology (1976)

Abstract All human T lymphoblast cell lines have been derived from subjects with leukemia secondary to thymic lymphoblastic lymphoma, a T cell malignacy, suggesting that such lines represent established cultures of neoplastic T cells. Based on this observation, we prepared rabbit antisera to T cell line HSB‐2, removed reactivity for histocompatibility antigens and normal T cells by absorption with autocthonous B cell line CCRF‐SB and normal thymocytes, and tested the absorbed antisera by complement‐dependent cytotoxicity against a panel of normal and malignant cells. A representative antiserum reacted with all 4 T cell lines (mean cytotoxic index = 56) and with tumor cells from 4 patients with T cell lymphma (mean cytotoxic index = 50) but did not react with tumor cells from 6 patients with other types of leukemias (mean cytotoxic index = 2), with 3 B cell lines (mean cytotoxic index = 1), normal peripheral blood lymphocytes (mean cytotoxic index = 5), or normal thymocytes (mean cytotoxic index = 6). We conclude that appropriately absorbed antisera to human T cell lines detect T cell lymphoma tumor antigens.
Culture Shock — Patient as Icon, Icon as Patient
Authors: Abraham Verghese
Journal: New England Journal of Medicine (2008)

On my first day as an attending physician in a new hospital, I found my house staff and students in the team room, a snug bunker filled with glowing monitors. Instead of sitting down to hear about the patients, I suggested we head out to see them. My team came willingly, though they probably felt that everything I would need to get up to speed on our patients — the necessary images, the laboratory results — was right there in the team room. From my perspective, the most crucial element wasn't.For the next few weeks, I ensured that we . . .
Is Hyperglycemia a Cardiovascular Risk Factor?
Authors: Frank Pistrosch, Andrea Natali, Markolf Hanefeld
Journal: Diabetes Care (2011)

Patients with diabetes show an increased vascular morbidity and mortality that reduces their life expectancy by ~5–15 years (depending on the age at diagnosis) (1). There is convincing evidence from epidemiological and pathophysiological studies that hyperglycemia per se is largely responsible for the harmful effects of the disease. As recently shown by clinical trials, treatment of this condition may reduce cardiovascular events and mortality, and several therapies should be considered: initiating early and individualized treatment and avoiding hypoglycemia.

As shown in the Multiple Risk Factor Intervention Trial, at any given level of major cardiovascular risk factors, diabetes is associated with an odds ratio of 2–4 for cardiovascular mortality compared with nondiabetic subjects (2). These results were confirmed by the European Prospective Investigation of Cancer and Nutrition (EPIC Norfolk) study (3) and a recent analysis of the Atherosclerosis Risk in Communities (ARIC) study (4).

Furthermore, a recently published 18-year follow-up study from Finland demonstrated a similar impact of type 1 and type 2 diabetes on cardiovascular mortality. The adjusted hazard ratios compared with age-matched subjects without diabetes were 5.2 and 4.9 for type 1 and type 2 diabetes, respectively (5).

Thus, today evidence exists on long-term follow-up population-based studies in patients with type 1 and type 2 diabetes. This evidence clearly suggests that hyperglycemia is a key risk factor not only for diabetes-related disease, but also for cardiovascular and all-cause mortality. On the basis of these long-term observations, one can assume an increment of cardiovascular disease per increase of 1 unit (%) A1C of ~18% (6).

As shown in numerous prospective studies, the deleterious effects of dysglycemia (fasting and postprandial hyperglycemia) develop before diabetes is diagnosed. In the Glucose Tolerance in Acute Myocardial Infarction study of patients with acute coronary syndrome, abnormal glucose tolerance was the strongest independent …
A View From Granddad’s Window
Authors: Irina Privorotskaya
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Joan's Education
Authors: Maryann Overland
Journal: Annals of Internal Medicine (2006)

On Being a Doctor16 May 2006Joan's EducationMaryann Overland, BAMaryann Overland, BAFrom University of Rochester, Rochester, NY 14620.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-10-200605160-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail There was a wad of bubblegum stuck to the upper right corner of Joan's windshield. From the looks of it, the gum had seen better days. Baked-on greasy streaks ran from the pink blob to the dashboard and told of countless seasons of climatic abuse. Every morning as she climbed into her 1993 Volvo, Naugahyde seat cracking and groaning under her increasing weight, Joan cursed her ex-boyfriend and made a mental note to clean the gum off the glass when she got home. As she buckled her seat belt, she noticed the roll of fat creeping over her formerly slim ... Author, Article, and Disclosure InformationAffiliations: From University of Rochester, Rochester, NY 14620.Corresponding Author: Maryann Overland, 135 Oakland Street, Rochester, NY 14620; e-mail, [email protected]Rochester.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 May 2006Volume 144, Issue 10Page: 777-778KeywordsAdolescentsEmotionsMemoryMouthSleepSyncopeTachycardiaTasteVisionWalking ePublished: 16 May 2006 Issue Published: 16 May 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Impact of pulmonary regurgitation and right ventricular dysfunction on oxygen uptake recovery kinetics in repaired tetralogy of Fallot
Authors: Alessandro Giardini, Salvatore Specchia, Gloria Coutsoumbas, Andrea Donti, Roberto Formigari, Rossella Fattori, Guido Oppido, Gaetano Gargiulo, Fernando M. Picchio
Journal: European Journal of Heart Failure (2006)
Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus.
Authors: P D Zenobi, S E Jaeggi-Groisman, W F Riesen, M E Røder, E R Froesch
Journal: Journal of Clinical Investigation (1992)

Hyperglycemia, hyperinsulinemia, and insulin resistance cause vascular disease in type 2 diabetes mellitus. Dietary treatment alone often fails and oral drugs or insulin enhance hyperinsulinemia. In previous studies, an intravenous bolus of recombinant human insulin-like growth factor-I (rhIGF-I) caused normoglycemia in insulin-resistant diabetics whereas rhIGF-I infusions lowered insulin and lipid levels in healthy humans, suggesting that rhIGF-I is effective in insulin-resistant states. Thus, eight type 2 diabetics on a diet received on five treatment days subcutaneous rhIGF-I (2 x 120 micrograms/kg) after five control days. Fasting and postprandial glucose, insulin, C-peptide, proinsulin, glucagon, triglyceride, insulin-like growth factor-I and -II, and growth hormone levels were determined. RhIGF-I administration increased total IGF-I serum levels 5.3-fold above control. During the control period mean (+/- SD) fasting glucose, insulin, C-peptide, and total triglyceride levels were 11.0 +/- 4.3 mmol/liter, 108 +/- 50 pmol/liter, 793 +/- 250 pmol/liter, and 3.1 +/- 2.7 mmol/liter, respectively, and decreased during treatment to a nadir of 6.6 +/- 2.5 mmol/liter, 47 +/- 18 pmol/liter, 311 +/- 165 pmol/liter, and 1.6 +/- 0.8 mmol/liter (P < 0.01), respectively. Postprandial areas under the glucose, insulin, and C-peptide curve decreased to 77 +/- 13 (P < 0.02), 52 +/- 11, and 60 +/- 9% (P < 0.01) of control, respectively. RhIGF-I decreased the proinsulin/insulin ratio whereas glucagon levels remained unchanged. The magnitude of the effects of rhIGF-I correlated with the respective control levels. Since rhIGF-I appears to improve insulin sensitivity directly and/or indirectly, it may become an interesting tool in type 2 diabetes and other states associated with insulin resistance.
Patient suicide (physician unassisted)
Authors: M. Phillips
Journal: BMJ (1995)

The first time I met Hoke he was sitting in a bed in the cardiac care unit, bare from the waist up except for a diamond necklace. He was an obese man in his mid-60s. His wide bald head was surrounded by a fringe of long grey hair. Festooned with electrodes, wires, and intravenous lines, he sat dignified and stern and seemed to be in no mood for light banter. After introducing myself I asked him: “What were you doing when the chest pain started?” He fixed me with an intense gaze and replied: “I was giving a policeman a blow job.”

I laughed, quite helpless to resist. His delivery was deadpan, professional, and hilariously funny. He looked quietly pleased. Many months later he told me that I had passed a crucial test at that moment. If I had not laughed he would have looked for another doctor. I learnt that this had been Hoke's third acute myocardial infarction. For many years he had been a successful florist in Washington, DC, but he had given up working since he was now virtually crippled by congestive heart …
Antitoxic Immunity to Cholera.
Authors: Nathaniel F. Pierce
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Antitoxic Immunity to Cholera.Nathaniel F. Pierce, M.D., F.A.C.P.Nathaniel F. Pierce, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-828_5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present whole-cell cholera vaccine stimulates only antibacterial antibodies and provides limited protection of brief duration. Since the effects of cholera are produced by a protein enterotoxin, it is possible that antitoxic immunity might provide an additional and perhaps more effective means of protection. The protective value of antitoxic immunity was evaluated in a canine model of the disease. Dogs were immunized parenterally with highly purified cholera entertoxin plus adjuvant and given a booster after 28 days. High serum antitoxin titers developed and persisted at 10 times preimmunization values for more than 300 days. Serum vibriocidal antibody titers did not... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe role of immune pig colostrum, serum and immunoglobulins IgG, IgM, and IgA in local intestinal immunity against enterotoxic strain ofEscherichia coli 055 in germfree pigletsImmunology of CholeraCholeraStimulation of Jejunal Secretion by a Crude Escherichia Coli EnterotoxinInfectious diseases: annual review of significant publications. 1 May 1971Volume 74, Issue 5Page: 828-828KeywordsAntibodiesAntitoxinsCholeraEnterotoxinsImmunityProteinsVaccines Issue Published: 1 May 1971 PDF downloadLoading ...
423. Increased Incidence of Hepatocellular Change and Neoplastic Disease in AAV-WPRE Treated Pahenu2 Mice
Authors: Jennifer E. Embury, Catherine E. Charron, Philip J. Laipis
Journal: Molecular Therapy (2005)

Phenylketonuria (PKU) is among the most common human birth defects occurring in approximately 1 in 16,000 births in the United States. The disease is caused by a single gene defect in the enzyme phenylalanine hydroxylase (PAH) which results in elevated serum phenylalanine (Phe) levels. Our laboratory is involved in the investigation of AAV applications for the treatment of this disease in a mouse model for PKU.
Decreased exhaled nitric oxide in sickle cell disease: Relationship with chronic lung involvement
Authors: Reda E. Girgis, Mohammed A. Qureshi, Judith Abrams, Paul Swerdlow
Journal: American Journal of Hematology (2003)

Abstract A deficiency in airway nitric oxide (NO) could contribute to pulmonary vaso‐occlusion in sickle cell disease (SCD). We measured the fractional expired concentration of NO (FE NO ) by chemiluminescence during a slow vital capacity maneuver against a positive pressure of 16 cm H 2 O at an expiratory flow rate of 50 mL/sec in 44 stable ambulatory adults with SCD and 30 healthy controls. A history of acute chest syndrome was present in 29 patients, and 22 complained of dyspnea. Mean ± SD FE NO was significantly reduced in the SCD group compared with controls (14.8 ± 8.4 vs. 24.9 ± 13.5 ppb, P &lt; 0.001). SCD patients with dyspnea had lower FE NO than those without dyspnea (10.1 ± 5.7 vs. 19.6 ± 8 ppb, P &lt; 0.001) and those with a history of ACS had lower values than those no episodes of ACS (13.0 ± 8.3 vs. 18.4 ± 7.6 ppb, P &lt; 0.05). There was a weak correlation between FE NO and percent‐predicted DLCO ( r = 0.4, P = 0.02) among the SCD patients. We conclude that exhaled NO is reduced in adults with SCD, and this may play a role in the pathogenesis of acute chest syndrome and chronic sickle cell lung disease. Am. J. Hematol. 72:177–184, 2003. © 2003 Wiley‐Liss, Inc.
Chronic Ulcerative Colitis Beginning in Children and Teenagers.
Authors: Marcel Patterson
Journal: Annals of Internal Medicine (1969)

s1 May 1969Chronic Ulcerative Colitis Beginning in Children and Teenagers.Marcel Patterson, M.D., F.A.C.P., Leo Castiglioni, M.D., Lloyd Sampson, M.D.Marcel Patterson, M.D., F.A.C.P.Search for more papers by this author, Leo Castiglioni, M.D.Search for more papers by this author, Lloyd Sampson, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1070_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis report describes our experience with 43 patients who developed symptoms of chronic ulcerative colitis during childhood or teenage years (1953 to 1966). The clinical picture is similar to that observed in adults except that these patients appear more ill and disabled by their disease. Seventy-one percent of the patients had total colon involvement, and 65% had complications of the disease when first seen. All patients but one have been followed to the present. Six patients (11%) have died: 2 from cancer, 2 from liver failure, and 2 from septicemia. All deaths occurred before age 30. Two patients with disease... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Marcel Patterson, M.D., F.A.C.P.; Leo Castiglioni, M.D.; Lloyd Sampson, M.D.Affiliations: Galveston, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1070-1070KeywordsAdolescentsChildrenColonLiverSepsisUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...