tbuckley/cabot-search huggingface dataset:
THE BACTERICIDAL ACTION OF PROPYLENE GLYCOL VAPOR ON MICROORGANISMS SUSPENDED IN AIR. I
Authors: O. H. Robertson, Edward Bigg, Theodore T. Puck, Benjamin F. Miller
Journal: The Journal of Experimental Medicine (1942)

It has been found that propylene glycol vapor dispersed into the air of an enclosed space produces a marked and rapid bactericidal effect on microorganisms introduced into such an atmosphere in droplet form. Concentrations of 1 gm. of propylene glycol vapor in two to four million cc. of air produced immediate and complete sterilization of air into which pneumococci, streptococci, staphylococci, H. influenzae, and other microorganisms as well as influenza virus had been sprayed. With lesser concentrations of propylene glycol, rapid and marked reduction in the number of air-borne bacteria occurred, but complete sterilization of the air required a certain interval of time. Pronounced effects on both pneumococci and hemolytic streptococci were observed when concentrations as low as 1 gm. of glycol to fifty million cc. of air were employed. Numerous control tests showed that failure of the glycol-treated microorganisms to grow on the agar plates was due to actual death of the bacteria. The means by which propylene glycol vapor produces its effect on droplet-borne bacteria is discussed and data relating the bactericidal properties of propylene glycol in vitro to the lethal action of its vapor is presented. Atmospheres containing propylene glycol vapor are invisible, odorless, and non-irritating. This glycol is essentially non-toxic when given orally and intravenously. Tests on possible deleterious effects of breathing propylene glycol containing atmospheres over long periods of time are being carried out.
A stinging wasp in the stomach: accidental endoscopic diagnosis of a systemic anaphylactic reaction
Authors: Girolamo Geraci, Giuseppe Modica, Carmelo Sciumè
Journal: Endoscopy (2015)

There are only four reported cases of bees or wasps being found as foreign bodies in the esophagus or stomach [1] [2] [3] [4]. We report the first case, to our knowledge, of a wasp puncture in the stomach causing local (acute heartburn) and systemic symptoms (anaphylaxis).
Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1
Authors: Adrian Israelson, Dara Ditsworth, Shuying Sun, SungWon Song, Jason Liang, Marian Hruska-Plochan, Melissa McAlonis-Downes, Salah Abu-Hamad, Guy Zoltsman, Tom Shani, Marcus Maldonado, Anh Bui, Michael Navarro, Huilin Zhou, Martin Marsala, Brian K. Kaspar, Sandrine Da Cruz, Don W. Cleveland
Journal: Neuron (2015)
Counselling patients before an HIV test.
Authors: R Bor, R Miller, M Johnson
Journal: BMJ (1991)

took a study of 2600 seafarers working with Belgian shipping companies.Of 336 screening tests, 15 (4-5%) yielded a positive result.This is extremely high, the average prevalence of HIV infection among Belgians being 0062%.3Thus, like prisoners, seafarers require management, treatment, education, and information is tailored to their circumstances.They need to be targeted as they pose complex logistical problems with regard to decreasing their risk.
The Effect of Leads Utilized Upon Discrepancies Between Spatial Vectors Recorded by SVEC and by Mean Vector Methods
Authors: ERNST SIMONSON, OTTO H. SCHMITT, HENRY W. BLACKBURN
Journal: Circulation Research (1955)

In a former study significant differences were found in the orientation and magnitude of spatial ECG vectors as determined using two different methods. The results presented in this series show that the difference in the leads used account for the major part of these discrepancies and thus emphasize the importance of a standardization of electrode position for spatial vectorcardiography.
Contribution of Abnormal Insulin Secretion and Insulin Resistance to the Pathogenesis of Type 2 Diabetes in Myotonic Dystrophy
Authors: Gianluca Perseghin, Andrea Caumo, Cinzia Arcelloni, Stefano Benedini, Roberto Lanzi, Emanuela Pagliato, Lucia Piceni Sereni, Giulio Testolin, Alberto Battezzati, Giancarlo Comi, Mauro Comola, Livio Luzi
Journal: Diabetes Care (2003)

Myotonic dystrophy (MyD), the most common adult form of muscular dystrophy, is often complicated by diabetes. MyD is dominantly inherited and is due to heterozygosity for a trinucleotide repeat expansion mutation in a protein kinase gene able to induce derangement of RNA metabolism responsible of an aberrant insulin receptor expression.To assess insulin sensitivity and secretion before the onset of diabetes, we studied 10 MyD patients, 10 offspring of type 2 diabetes (OFF), and 10 healthy subjects with no family history of diabetes (control subjects) with dual X-ray energy absorption, euglycemic-hyperinsulinemic clamp (40 mU/[m(2). min]) combined with infusion of [6,6-D(2)]-glucose and oral glucose tolerance test (OGTT).MyD had reduced lean body mass, but peripheral insulin sensitivity was not different to that of control subjects in contrast to OFF, which showed insulin resistance. Insulin secretion, obtained by deconvolution of OGTT data, was also shown to be comparable with that of OFF and control subjects (index of beta-cell function = Phi; P = 0.91) even if increased parameters of insulin secretion were found during the first 30 min (Phi(30); P = 0.05) of the oral glucose challenge. Fasting plasma proinsulin concentrations (P = 0.01) and the ratio to insulin (P = 0.01) were increased in MyD patients. The proinsulin levels also failed to be suppressed during the clamp and showed exaggerated response after the OGTT. Increased proinsulin levels were shown to be peculiar of MyD patients when compared with OFF.In nondiabetic, young MyD patients, insulin sensitivity was preserved, and an increased early secretory response to oral glucose was detected. Abnormal plasma proinsulin levels in the fasting state, during the clamp, and during the OGTT were shown to be secretory dysfunctions peculiar of MyD patients and may be more important than insulin resistance in determining the high risk to develop diabetes in these patients.
Component-resolved in vitro diagnosis of hazelnut allergy in Europe
Authors: Kirsten Skamstrup Hansen, Barbara K. Ballmer-Weber, Joaquin Sastre, Jonas Lidholm, Kerstin Andersson, Hubert Oberhofer, Magdalena Lluch-Bernal, Jonas Östling, Lars Mattsson, Frauke Schocker, Stefan Vieths, Lars K. Poulsen
Journal: Journal of Allergy and Clinical Immunology (2009)
Epithelial cells undergoing epithelial mesenchymal transition (EMT) in systemic sclerosis lack caveolin-1 and modulate WNT signaling in the dermis by secreting SFRP4
Authors: J. Gillespie, I. Tinazzi, C. Colato, F. Benedetti, D. Biasi, P. Caramaschi, P. Emery, F. D. Galdo
Journal: Annals of the Rheumatic Diseases (2011)

<h3>Background</h3> Systemic sclerosis is a chronic fibrotic disease highly heterogeneous in clinical outcome, involving autoimmune activation, fibroproliferative vasculopathy and tissue fibrosis of skin and multiple internal organs. The mechanisms linking immune activation and tissue fibrosis are still not fully characterised. A widely accepted model of immune-mediated skin fibrosis is chronic sclerodermoid graft versus host disease (Scl-GVHD), a form of chronic GVHD in patients receiving allogenic bone marrow transplant. Histopathologic studies of cGVHD skin biopsies confirmed the presence of both fibroproliferative vasculopathy and tissue fibrosis in Scl-GVHD. <h3>Objective</h3> To identify which genes are differentially expressed in SSc skin biopsies are similarly expressed in the transcriptome of Scl-GVHD skin biopsies and therefore of potential importance in linking immune activation and skin fibrosis. <h3>Methods</h3> Metanalysis of microarray data published in the literature identified a set of 80 genes whose differential expression is highly reproduced in our SSc skin biopsies signature. The mRNA expression level of these genes was then analysed in eight Scl-GVHD and three cGVHD skin biopsies, and compared to normal skin and their differential expression in SSc. Genes found to be significantly differentially expressed (p&lt;0.05) in univariate analysis were tested in multivariate analysis. To validate our mRNA findings we preformed immunofluorescence studies on skin biopsies. <h3>Results</h3> 46 genes were differentially expressed in cGVHD biopsies and 34 remained unique of SSc. 78.3% of the differentially expressed genes had a similar pattern of regulation in SSc. 25% were similarly expressed in both cGVHD variants, whereas 16.6% were specific of Scl-GVHD. Remarkably, this analysis identified several chemokines (CCL5, CXCL9-10-11) specifically involved in the fibrotic versus non-fibrotic response in GVHD and also increased expression of SFRP4, a potent angiogenesis inhibitor, in SSc and Scl-GVHD. Using confocal microscopy we identified as the source of increased SFRP4, cells in the basal layer of the epidermis which lost E-cadherin expression, co-expressed vimentin and specifically lacked Caveolin-1 expression. <h3>Conclusion</h3> Approximately 50% of SSc signature genes presented an altered expression in cGVHD. The further characterisation of the cells that play a role both in the fibrotic process, by undergoing EMT, and in the vasculopathy, by inhibiting angiogenesis through SFRP4 inhibition of WNT signalling, may pave the way to understand the link between these two processes in SSc.
Sexual Attitudes and Lifestyles
Authors: Warren W. Webb, Marc H. Hollender
Journal: JAMA (1995)

Propelled into action by the AIDS epidemic and building upon prior surveys of sexual behavior, this study of "a representative sample of the British population" was carried out from 1986 to 1994. The authors (faculty of two British medical schools and an institute) designed the study with a view to many critical issues. Knowing that some especially health-risky behaviors were practiced by small numbers of people, the researchers calculated that they must have approximately 20 000 interviewees. Knowing that their data should be amenable to comparison with data from similar surveys, they used standard questions where possible. Knowing of the sensitivities to sexual issues of the public, the government, the respondents, and the interviewers, they carefully phrased and pretested all items. Knowing of latent sources for bias, they trained their interviewers (dropping the few who were uncomfortable), let respondents choose the sex of their interviewer, and hewed rigidly to a
A PARANOID STATE IN A PATIENT SUFFERING FROM SHEEHAN SYNDROME
Authors: HENRICUS WIJSENBEEK, YITZHAK KRIEGEL, BARUCH LANDAU
Journal: American Journal of Psychiatry (1964)

The authors described another case of Sheehan's syndrome accompanied with a mental syndrome characterized by paranoid thoughts, apathy and a complete lack of will power. The combination of pituitary insufficiency and mental disturbances of this type seem to be rare. Substitution therapy improved the patient's physical and mental state. The physical and mental signs and symptoms are identical to those described by other authors. The interrelationship between hormonal state and psyche is again demonstrated in this case.
Treatment of von Willebrand disease with a high-purity factor VIII/von Willebrand factor concentrate: a prospective, multicenter study
Authors: Pier M. Mannucci, Juan Chediak, Wahid Hanna, John Byrnes, Marlies Ledford, Bruce M. Ewenstein, Anastassios D. Retzios, Barbara A. Kapelan, Richard S. Schwartz, Craig Kessler
Journal: Blood (2002)
Cost‐effectiveness of neonatal IgE‐screening for atopic allergy before 7 years of age
Authors: K. Hjalte, S. Croner, N.‐I. Max Kjellman
Journal: Allergy (1987)

Obvious atopic diseases developed in 18% of 1651 non‐selected children before 7 years of age. More than 80% of newborns with high IgE concentrations in cord blood developed atopic diseases before this age. Although the sensitivity of the IgE test is rather low (40%), most cases (94%) of severe, long‐lasting atopic disease show a high neonatal IgE concentration, and the specificity of the test is high (94%), Calculations of total costs of screening were made on the basis of family history alone compared with neonatal IgE‐screening in two groups: (i) all newborn infants, or (ii) infants with a family history of atopic disease. The cost of preventive measures and treatment costs were included in the total patient compliance) then IgE‐screening was cost‐effective in both groups, which screening solely on a basis of family history was not. In Sweden there was a total saving of approx, 20 million SEK or 3 million USS per annum. Thus, IgE‐screening of cord blood to select newborns for preventive measures is also economically worthwhile.
Removing barriers for disabled people would be giant leap
Authors: J. M Carter
Journal: BMJ (2002)

EDITOR—Emery and Buch's editorial about drug treatment for rheumatoid arthritis states that after 10 years 50% of people with the disease no longer work, most losing their jobs in the first 12 months after diagnosis.1 But it is not necessarily rheumatoid arthritis that causes job loss; it is likely also to be due to the barriers in society that exclude disabled people from full employment.

I have had rheumatoid arthritis for over 10 years, and have …
Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression.
Authors: T L Orenstein, T G Parker, J W Butany, J M Goodman, F Dawood, W H Wen, L Wee, T Martino, P R McLaughlin, P P Liu
Journal: Journal of Clinical Investigation (1995)

Continued adverse remodeling of myocardium after infarction may lead to progressive ventricular dilation and heart failure. We tested the hypothesis that exercise training in a healed myocardial infarction-dysfunction rat model can favorably modify the adverse effects of ventricular remodeling including attenuation of abnormal myosin gene expression. Sprague-Dawley rats were subjected to either proximal LAD ligation or sham operation. At 5 wk after the operation, animals were randomly assigned to sedentary conditions or 6 wk of graduated swim training, creating four experimental groups: infarct sedentary (IS), infarct exercise (IE), sham sedentary (SS), and sham exercise (SE). At 11 wk all rats were sacrificed and analyzed. Compared to sedentary infarct controls, exercise training attenuated left ventricular (LV) dilation and allowed more hypertrophy of the non infarct wall. The exercise-trained hearts also showed a reduction in the estimated peak wall tension. Northern blot analysis showed an increase in beta-myosin heavy chain expression in the hearts of the sedentary infarction group soon after infarction when compared to sham controls. However, with exercise training, there was a significant attenuation of the beta-myosin heavy chain expression in the myocardium. Exercise training in a model of left ventricular dysfunction after healed myocardial infarction can improve the adverse remodeling process by attenuating ventricular dilation and reducing wall tension. The abnormal beta-myosin expression was also attenuated in the exercise trained group. This is evidence that abnormal gene expression following severe myocardial infarction dysfunction can be favorably modified by an intervention.
Midline Catheterization in Hospitalized Patients
Authors: Leonard A. Mermel
Journal: Annals of Internal Medicine (1996)

Letters15 October 1996Midline Catheterization in Hospitalized PatientsLeonard A. Mermel, DO, ScM, Stephen Parenteau, MS, and Sen Mee Tow, BSN, CRNILeonard A. Mermel, DO, ScMRhode Island Hospital, Providence, RI 02903Search for more papers by this author, Stephen Parenteau, MSRhode Island Hospital, Providence, RI 02903Search for more papers by this author, and Sen Mee Tow, BSN, CRNIRhode Island Hospital, Providence, RI 02903Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-8-199610150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Manzella and colleagues did not observe the adverse reactions that we and others [1] described; however, Moorcroft and associates did, and they noted a similar incidence rate. Regarding Dr. Evans' comments, the Teflon catheters were 0.75 to 1.25 inches long and were inserted during the study period in hospitalized patients by the same nursing group that inserted the Landmark catheters.Regarding the comments of Drs. Terr and Bloch, our patients' symptoms resembled anaphylactoid reactions associated with first use of cuprophane dialyzers; fewer than 20% had urticaria or angioedema, and symptoms resolved despite continued use of the device [2]. ...References1. Blum DY. Untoward events associated with use of midterm I.V. devices. J Intraven Nurs. 1995; 18:116-9. Google Scholar2. Hakim RM, Breillatt J, Lazarus M, Port FK. Complement activation and hypersensitivity reactions to dialysis membranes. N Engl J Med. 1984; 311:878-82. Google Scholar3. Adverse Medical Device Experience Report for Menlo Care from the Device Experience Network. Washington, DC: Office of Surveillance and Biometrics, Center for Devices and Radiographic Health, Food and Drug Administration; 1996. Google Scholar4. Verresen L, Fink E, Lemke HD, Vanrenterghem Y. Bradykinin is a mediator of anaphylactoid reactions during hemodialysis with AN69 membranes. Kidney Int. 1994; 45:1497-503. Google Scholar5. Adverse reactions associated with midline catheters—United States, 1992-1995. MMWR Morb Mortal Wkly Rep. 1996; 45:101-3. Google Scholar Author, Article, and Disclosure InformationAuthors: Leonard A. Mermel, DO, ScM; Stephen Parenteau, MS; Sen Mee Tow, BSN, CRNIAffiliations: Rhode Island Hospital, Providence, RI 02903 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdverse reactions due to Aquavene� 15 October 1996Volume 125, Issue 8Page: 697KeywordsAdverse eventsAdverse reactionsCathetersFood and Drug AdministrationHeartHistamineHypotensionIschemiaPruritusUrticaria ePublished: 15 August 2000 Issue Published: 15 October 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
TCT-301 Is there a role for BivaliRUdin in Transradial Percutaneous Coronary Intervention? - The BRUT PCI Study
Authors: Sundeep Adusumalli, Gregory Harris, Arjun Chagarlamudi, Gary M. Nash, Adeel Siddiqui, Nikhil Paladugu, Ramesh B. Daggubati
Journal: Journal of the American College of Cardiology (2013)
Death During Jogging-Reply
Authors: Paul D. Thompson
Journal: JAMA (1983)

<h3>In Reply.—</h3> Dr Bassler's comments are appreciated and provocative. Relative risk is the rate of death during jogging divided by the rate during sedentary activity. It can decrease with either a decrease in the jogging or an increase in the sedentary death rate. Furthermore, the absolute risk of jogging in our study increased with age. This is expected if CHD was responsible for the majority of the exercise-related deaths. Despite Dr Bassler's experience, autopsies in seven of our CHD victims showed advanced disease. Another four men were not examined—two died with chest pain and two had suffered prior myocardial infarctions. Dr Bassler's implication that CHD does not cause exercise-related deaths in adults contrasts with these results and other published reports,<sup>1</sup>but we eagerly await presentation of his experience. Dr Bassler rejects a premise that is not ours. We did not calculate the risk of jogging for men with CHD.
The effect of immunotherapy on T‐cell subsets in peripheral blood and bronchoalveolar lavage fluid in pollen‐allergic patients
Authors: S. Rak, G. Hallden, S. Sörenson, V. Margari, A. Scheynius
Journal: Allergy (1993)

The effect of immunotherapy (IT) on T‐cell subsets in peripheral blood and bronchoalveolar lavage fluid (BAL) was examined in 15 patients with rhinoconjunctivitis and asthma caused by sensitivity to birch pollen. They were treated with IT for 3 years. Seven patients were treated with highly standardized birch‐pollen extract (Pharmacia, Sweden). Eight untreated patients served as controls. Histamine challenge, blood sampling, and BAL were performed before (January, February), and at the peak of, the birch‐pollen season (May). The subpopulations of T cells in peripheral blood and BAL fluid were investigated by immunocytochemistry and flow cytometry. During the birch‐pollen season, the percentage of CD3+ and CD4+ cells of blood mononuclear cells in the IT patients increased significantly ( P &lt;0.03 and P &lt;0.02, respectively). The percentage of CD8 + cells remained unaltered. In control patients, no changes of T‐cell subsets in the peripheral blood were observed. T‐cell subsets in BAL did not change during the season in relation to preseasonal values for either IT‐treated or non‐IT‐treated patients.
Thermography for Breast Cancer Diagnosis
Authors: Harold J. Isard
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The MEDICAL NEWS item, "In the Hot Seat: Thermography for Breast Cancer Diagnosis," published in the Feb 10,1984, issue ofThe Journal,<sup>1</sup>deserves additional attention and comment. The pejorative tenor of both the report and the strongly worded policy statement of the American College of Radiology does a disservice to American women as well as to your readers. In a recent issue of<i>CA: A Cancer Journal for Clinicians</i>, Gerald D. Dodd, Jr, MD,<sup>2</sup>credited by MEDICAL NEWS as the spokesman for the American College of Radiology, notes that it took 30 years of neglect and 20 years of controversy before the initial considerable resistance by radiologists to the adoption of x-ray mammography was overcome and the technique was ultimately accepted. It appears that in 1984 the reluctant attitude of some of my radiological colleagues may be responsible for consigning breast thermography to a similar
Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope*1
Authors: Patrick S. C. Leung, David T. Chuang, R. Max Wynn, Sanghoon Cha, Dean J. Danner, Aftab Ansari, Ross L. Coppel, M. Eric Gershwin
Journal: Hepatology (1995)

Primary biliary cirrhosis (PBC) is an autoimmune disease of liver associated with a unique serologic response to mitochondrial autoantigens. Many of the autoantigens recognized by autoantibodies in PBC are members of the 2-oxo-acid dehydrogenase complex. The two major autoantigens are the E2 component of the pyruvate dehydrogenase complex (PDC-E2) and the E2 component of the branched chain 2-oxo-acid dehydrogenase complex (BCOADC-E2). The autoantibody response to PDC-E2 has been mapped to one immunodominant epitope, which consists of both linear and conformational components. The presence of a single immunodominant epitope in PDC-E2 is unusual when contrasted to the immune response to autoantigens in other human autoimmune diseases. We have mapped the epitope recognized by antimitochondrial autoantibodies (AMA) specific to BCOADC-E2 in patients with PBC by taking advantage of the full-length bovine BCOADC-E2 complementary DNA (cDNA) and a series of expression clones spanning the entire molecule. Reactivity to the various expression clones was studied by immunoblotting, enzyme-linked immunosorbent assay (ELISA), as well as selective absorption of patient sera by expressed protein fragments. Autoantibodies to BCOADC-E2 map within peptides spanning amino acid residues 1 to 227 of the mature protein; our data demonstrate that the epitope is dependent on conformation and includes the lipoic acid binding region. However, only the full-length clone (amino acid residue 1 to 421) is sufficient to remove all detectable BCOADC-E2 reactivity. Moreover, the absence of lipoic acid on the recombinant polypeptides used in this study indicates that antibody binding to BCOADC-E2 is not dependent on the presence of lipoic acid.