Fibrosing Alveolitis in the Adult Respiratory Distress Syndrome
Authors: Michael A. Matthay
Journal: Annals of Internal Medicine (1995)

Editorials1 January 1995Fibrosing Alveolitis in the Adult Respiratory Distress SyndromeMichael A. Matthay, MDMichael A. Matthay, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-1-199501010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this issue, Clark and coworkers [1] make a valuable contribution to our understanding of the adult respiratory distress syndrome. They measure a biological marker of collagen synthesis, type III procollagen (procollagen III), in bronchoalveolar lavage fluid from patients with the adult respiratory distress syndrome. Their study indicates that elevated levels of procollagen III identify those patients at increased risk for death.The rationale for their study was based on several previous observations. First, fibrosing alveolitis is a well-recognized morphologic finding in most patients dying with the adult respiratory distress syndrome [2, 3]. Second, increased levels of collagen have been ...References1. Clark JG, Milberg JA, Steinberg KP, Hudson LD. Type III procollagen peptide in adult respiratory distress syndrome. Association of increased peptide levels in bronchoalveolar lavage with increased risk for death. Ann Intern Med. 1994; 122:17-23. Google Scholar2. Lamy M, Fallat RJ, Koeniger E, Dietrich HP, Ratliff JL, Eberhart RC, et al. Pathologic features and mechanisms of hypoxemia in the adult respiratory distress syndrome. Am Rev Respir Dis. 1976; 114:267-84. Google Scholar3. Fukuda YM, Ishizaki M, Masuda Y, Kimura G, Kawanami O, Masugi Y. The role of intraalveolar fibrosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage. Am J Pathol. 1987; 126:171-82. Google Scholar4. Crouch E. Pathobiology of pulmonary fibrosis. 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Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trialsPulmonary Edema and Acute Lung Injuryβ-Adrenoceptor stimulation of alveolar fluid clearance is increased in rats with heart failureAlveolar Epithelial Repair in Acute Lung InjuryPentoxifylline-More evidence that it improves host defenses during sepsisUpregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycinALI and the Alveolar Epithelial BarrierSoluble Transforming Growth Factor-α Is Present in the Pulmonary Edema Fluid of Patients With Acute Lung InjuryCritical Role of the Alveolar Epithelial Barrier 1 January 1995Volume 122, Issue 1Page: 65-66KeywordsAcute respiratory distress syndromeBiomarkersBronchoalveolar lavageDeath ratesLungsNeutrophilsProteinsPulmonary fibrosisRespiratory failureSepsis Issue Published: 1 January 1995 CopyrightCopyright © 1995 by American College of Physicians. 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