tbuckley/cabot-search huggingface dataset:
Abuse of the Supplemented Fast
Authors: Victor Vertes
Journal: JAMA (1977)

The marketing of protein supplements for weight reduction without prescription or provision for medical care is a source of concern to physicians who believe strongly in the value of supplemented fasting for treatment of morbid obesity. Those of us who are involved in the management of supplemented fasting programs and who are aware of their problems as well as their benefits are especially distressed by this increasing abuse of a medical treatment.  It was not until 1971, after considerable laboratory and clinical investigation, that we felt qualified to offer supplemented fasting to patients in need of immediate weight reduction (those at least 22.5 kg overweight). Recognizing the slowness and inefficacy of most reducing regimens and the hazardous effects of total fasting, we designed what has proved to be a comfortable, safe method of rapid weight loss for use by a selected patient population. Unfortunately, as with other weight-reduction techniques, the
Three Stages of Group Psychotherapy
Authors: Henry Greenbaum
Journal: Psychotherapy and Psychosomatics (1959)

Research Articles| February 10 2010 Three Stages of Group Psychotherapy Subject Area: Psychiatry and Psychology Henry Greenbaum Henry Greenbaum Forest Hills, L.I., N. Y. Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1959) 7 (Suppl. 1): 146–149. https://doi.org/10.1159/000285431 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Henry Greenbaum; Three Stages of Group Psychotherapy. Acta Psychotherapeutica et Psychosomatica 1 January 1959; 7 (Suppl. 1): 146–149. https://doi.org/10.1159/000285431 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1959Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Convulsive Disorders and Participation in Sports
Authors: Samuel Livingston
Journal: JAMA (1969)

<h3>To the Editor:—</h3> An article entitled "Convulsive Disorders and Participation in Sports and Physical Education" (<b>206</b>:1291, 1968) stated that "... young people with convulsive disorders, once the seizures are under reasonable control, should be encouraged to lead as normal and active a life as possible." This article concludes by stating that "... participation should include any sports of interest with the exception of boxing, tackle football, ice hockey, diving, soccer, rugby, lacrosse, and other activities where chronic recurrent head trauma may occur." These recommendations are, in my opinion, contradictory. Certainly, it is possible for a controlled epileptic to participate in the sports, such as those listed in this paper as prohibited. Apparently the individuals who formulated the recommendations presented in this paper believe that chronic recurrent head trauma unequivocally causes a recurrence of preexisting epileptic seizures. I take issue with this conclusion for many reasons, among which I call attention to
First- or Second-line Therapy with Gefitinib Produces Equal Survival in Non–Small Cell Lung Cancer
Authors: Jenn-Yu Wu, Chong-Jen Yu, Chih-Hsin Yang, Shang-Gin Wu, Yueh-Hsia Chiu, Chien-Hung Gow, Yeun-Chung Chang, Ya-Chieh Hsu, Pin-Fei Wei, Jin-Yuan Shih, Pan-Chyr Yang
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Rationale: Gefitinib is effective in treating patients with non–small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. Deletions in exon 19 and L858R in exon 21 are the best-documented EGFR mutations that are associated with effective gefitinib responsiveness.Objectives: To clarify the influence of gefitinib timing, we conducted a study to compare the outcomes of different lines of gefitinib treatment in patients with exon 19 deletions or L858R.Methods: We surveyed the clinical data and mutational studies of patients with NSCLC with EGFR mutations in the National Taiwan University Hospital (Taipei, Taiwan).Measurements and Main Results: Three hundred and twenty-eight patients, who received gefitinib for stage IIIb or IV NSCLC, were adequately sequenced for EGFR mutations; 192 patients had mutant EGFR, including 77 patients with exon 19 deletions and 75 patients with L858R. The 152 patients with exon 19 deletions or L858R and who were receiving gefitinib were classified into a chemonaive group (91 patients) or a chemotherapy-treated group (61 patients). Chemonaive status before gefitinib and female sex were associated with clinical response to gefitinib (P = 0.006 and 0.053, respectively). Neither overall survival after the start of antitumor therapy nor progression-free survival after gefitinib therapy was significantly different between these two groups (P = 0.207 and 0.804, respectively). Clinical response to gefitinib was the only factor associated with better overall survival (P = 0.001).Conclusions: This study suggests that gefitinib is effective in patients with EGFR mutations. The gefitinib response rate in chemonaive patients is higher than in chemotherapy-treated patients; however, there is no difference in overall survival.
Well‐Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer
Authors: Chih‐Kuang Chen, Wing‐Cheung Law, Ravikumar Aalinkeel, Bindukumar Nair, Atcha Kopwitthaya, Supriya D. Mahajan, Jessica L. Reynolds, Jiong Zou, Stanley A. Schwartz, Paras N. Prasad, Chong Cheng
Journal: Advanced Healthcare Materials (2012)

Abstract Well‐defined tertiary amine‐functionalized cationic polylactides (CPLAs) are synthesized by thiol‐ene click functionalization of an allyl‐functionalized polylactide, and utilized for the delivery of interleukin‐8 (IL‐8) siRNA via CPLA‐IL‐8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity is relatively low. The CPLA‐IL‐8 siRNA nanoplexes can be readily taken up by prostate cancer cells, resulting in significant IL‐8 gene silencing. It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA‐IL‐8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs.
EC recognises threat to use of MRI
Authors: Rory Watson
Journal: BMJ (2007)

The European Commission has confirmed for the first time that it is prepared to delay the start of, and amend if necessary, European Union health and safety legislation that critics warn might restrict the use of magnetic resonance imaging (MRI).

The announcement by the social affairs commissioner, Vladimir Spidla, follows the launch in March of the Alliance for MRI campaign, which has brought together medical specialists, patients' groups, and European parliamentarians.

They have argued that the measures designed to protect employees from short term exposure to electromagnetic fields would inadvertently make it harder …
Cryosurgery of Malignant Neoplasms of the Head and Neck
Authors: James R. Chandler
Journal: JAMA (1972)

Cryosurgical techniques were used in the treatment of 50 patients, 32 of whom were treated for cure. The primary tumor has been controlled in 56%; treatment failed in 38%, and two operative deaths resulted. Cryosurgery is a valuable additional technique in the treatment of certain malignant head and neck tumors. It is particularly useful in the management of recurrent carcinoma following accepted surgical and radiotherapeutic procedures. Care is necessary in the selection of patients. Palliative benefits are few if any. Cryosurgery should be used in an aggressive manner in an attempt to salvage patients otherwise felt to be incurable. Vigorous treatment of desperately ill patients will result in significant morbidity and possible mortality. It should also result in some cures.
Hepatosplenic γδ T‐cell lymphoma presenting with immune‐mediated thrombocytopenia and hemolytic anemia (Evans' syndrome)
Authors: G. Motta, F. Vianello, C. Menin, A. De Nicolo, S. Agata, G. Altavilla, F. Pietrogrande, A. Girolami
Journal: American Journal of Hematology (2002)

We describe an unusual case of hepatosplenic T-cell lymphoma in a 61-year-old man who presented with fever, hepatosplenomegaly, anemia, and thrombocytopenia. A spleen biopsy was consistent with T-cell lymphoma. Cytogenetic studies did not reveal chromosome abnormalities. Using the polymerase chain reaction approach, clonality of the T-cell receptor gamma-chain gene rearrangement could be demonstrated, while Southern blot analysis disclosed only a germline configuration of the T-cell receptor beta chain genes. Of interest, an immune-mediated mechanism was demonstrated and was most likely responsible for erythrocyte and platelet destruction; this is, therefore, the first report of gamma T-cell lymphoma in association with Evans' syndrome. Initial steroid treatment was efficacious in limiting autoimmunity but constitutional symptoms did not subside. Chemotherapy (MACOP-B) was successful in obtaining complete clinical remission. Finally, thrombocytopenia in gammadelta T-cell lymphoma patients should be routinely evaluated for platelet autoantibodies.
Ethnicity and Emergency Department Analgesia-Reply
Authors: Knox H. Todd
Journal: JAMA (1993)

<h3>In Reply.</h3> —Dr Mariani suggests that levels of pain and distress recorded in physicians' and nurses' notes might explain the disparity in analgesic administration between Hispanics and non-Hispanic whites. While we agree that this is an important question, such data tend to be inconsistently and imprecisely recorded in the medical record and thus could not be measured with any accuracy. We recently completed a study of the effect of ethnicity on the ability of physicians to assess pain accurately, and we plan to report these findings in the near future. Dr Morfesis questions whether alcohol intoxication, severity of injury, or socioeconomic status might confound our results. As noted in our discussion, records mentioning alcohol or other drug use were excluded, and time of day, occupational injury, and mechanism were controlled as potential proxies for alcohol or other drug use, with no change in our results. In addition, Hispanics tended to
Withdrawal of Albuterol Inhalers Containing Chlorofluorocarbon Propellants
Authors: Leslie Hendeles, Gene L. Colice, Robert J. Meyer
Journal: New England Journal of Medicine (2007)

The Montreal Protocol requires limitation of the use of devices powered by chlorofluorocarbons (CFCs), which reduce stratospheric ozone levels. Albuterol, a medication commonly used for the treatment of asthma that is delivered by metered-dose inhalers with CFCs as propellants, will be withdrawn from the U.S. market by December 2008. This review article summarizes useful information about albuterol in metered-dose inhalers with non-CFC propellants and discusses associated economic issues.
Renal Sodium-Potassium-Activated Adenosine Triphosphatase and Sodium Reabsorption
Authors: M. Martinez-Maldonado, J. C. Allen, C. Inagaki, N. Tsaparas, A. Schwartz
Journal: Journal of Clinical Investigation (1972)

The role of renal Na(+),K(+)-ATPase in sodium reabsorption was further examined in dogs in which digoxin, a specific inhibitor of the enzyme system, was infused into one renal artery in doses ranging from 0.4 to 0.9 mug/kg/min (low dose) and from 1.0 to 4.0 mug/kg/min (high dose). A significant natriuresis occurred with both dose ranges which was accompanied by inhibition of Na(+),K(+)-ATPase of cortex and medulla in the infused kidney. Despite over 90% enzyme inhibition in many experiments, at least 80% of the filtered sodium continued to be reabsorbed. The per cent change in enzyme activity correlated with the rate of digoxin administration and the total dose administered but not with changes in sodium excretion. Changes in medullary Na(+),K(+)-ATPase activity, however, bore a direct relationship to alterations in fractional solute free water reabsorption (T(c) (H2O)). Inhibition of cortical enzyme activity alone was not associated with natriuresis, suggesting that medullary enzyme activity must be depressed for increased sodium excretion to occur during digoxin infusion. In high-dose experiments, significant inhibition of cortical and medullary enzyme in the contralateral control kidney was also observed, but natriuresis did not occur. In these experiments the rate at which digoxin reached the control kidney rose progressively but never equaled the rates in the directly infused kidney with either dose. Nevertheless, it is clear that under certain circumstances enzyme inhibition of either cortex or medulla need not be accompanied by natriuresis. We conclude that the major role of renal Na(+),K(+)-ATPase is in sodium reabsorption in the medulla (ascending limb of Henle's loop) and that it has a relatively small role in proximal sodium reabsorption. The kidney can rely on other sodium reabsorptive mechanisms depending on the rate of enzyme inhibition, so that natriuresis may not occur at all if depression in activity occurs "slowly." The nature of these mechanisms is not clear.
Beatrice's Choice
Authors: Sara Cichowski
Journal: JAMA (2002)

Beatrice did not greet me as I walked into the exam room, and I knew something was wrong. "I'm worried. I only think about one thing," she began. "When I return to Sudan I must be circumcised. But I fear the pain, and I have seen infection kill my cousins. I want you to perform my circumcision."
Cirrhosis and Methotrexate Treatment of Psoriasis
Authors: Robert Auerbach
Journal: JAMA (1969)

To the Editor:—  Regarding the article by Coe and Bull, Cirrhosis Associated With Methotrexate Treatment of Psoriasis ( 206 :1515, 1968), I would like to make the following points:  One hundred milligrams of methotrexate intravenously administered is too large for a first dose ( Arch Derm  89 :550, 1964). Certainly a first dose should be a test dose of no more than 25.0 mg or 0.5 mg/kg, whichever is less. The second two doses of methotrexate were given with a three-day interval; this interval is much closer than the recommended schedule for the treatment of psoriasis.  In both this and the other patients the schedule involved five days of treatment and a two-day rest period. This was continued for 11 to 42 months. The rest periods were not long enough. There should be at least four to five days between courses of orally administered therapy. It would be most unusual to have to keep
Ventricular fibrillation thresholds in the presence of leakage currents
Authors: J. R. LEDSOME, P. GRAYSTONE, J. COPPIN, T. LEUNG
Journal: Cardiovascular Research (1974)

Experiments were performed on young healthy dogs anaesthetized with a mixture of nitrous oxide and halothane. A fluid-filled catheter was introduced into the right ventricle of these animals and a 60 Hz electrical current was caused to flow down the catheter. It was found that complete loss of organized ventricular contractions and consequent fall in arterial pressure occurred at a current of less than 20 μA in a significant number of cases and was five times lower than that needed to cause sustained ventricular fibrillation.
Houses of Lords backs government plans for new disability payments
Authors: N. Hawkes
Journal: BMJ (2012)

The government has won a key vote in the House of Lords, defeating attempts to delay the introduction of new disability payments. It is now expected to overturn in the Commons three amendments to the bill passed in the Lords last week, and will seek to have the bill certified as a “money bill” by the Commons speaker, which would prevent the Lords from imposing any further delays.

Baroness Grey-Thompson, who gained fame as a successful disabled athlete, sought to postpone the introduction of a new benefit, personal independent payment (PIP), which will replace the existing disability living allowance. Her amendment would have introduced a pilot scheme to test the working of PIP before full introduction. She said that this was necessary because of uncertainty about who would qualify for the new benefit and who would not.

Lord …
Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura
Authors: Fumiaki Banno, Koichi Kokame, Tomohiko Okuda, Shigenori Honda, Shigeki Miyata, Hisashi Kato, Yoshiaki Tomiyama, Toshiyuki Miyata
Journal: Blood (2005)
Thrombophlebitis in Systemic Lupus Erythematosus
Authors: Brian Peck
Journal: JAMA (1978)

Thrombophlebitis occurred in 14 (12.2%) of 114 patients with active systemic lupus erythematosus (SLE). Abnormal clotting occurred despite the presence of thrombocytopenia or circulating anticoagulants in some of the patients, and the development of pulmonary emboli was verified in seven. Although infrequently reported, the association of thrombophlebitis with active SLE is apparently not uncommon. While there were no features that distinguished this group of patients from other groups of patients with SLE, there are some possible mechanisms. Recognition of this complication of SLE is important because of the frequent occurrence of SLE-induced pleuritis and its similarity to the pain of pulmonary emboli. (<i>JAMA</i>240:1728-1730, 1978)
Major Basic Protein Homolog (MBP2): A Specific Human Eosinophil Marker
Authors: D.A. Plager, D.A. Loegering, J.L. Checkel, J. Tang, G.M. Kephart, P.L. Caffes, C.R. Adolphson, L.E. Ohnuki, G.J. Gleich
Journal: Journal of Allergy and Clinical Immunology (2006)
THE PRINCIPLE OF ANOCI-ASSOCIATION APPLIED TO MEDICAL PRACTICE
Authors: F. M. Rowland
Journal: BMJ (1915)

THM B xuRoyal College of Physicians of London, as to the right of a medical graduate to style himnself " physician," and the answer given: That Dr. of Physic (nlot Doctor of Medicine) was the highest title a practiser of Physic could hiave.It may be, tllen, that Chaucer implied that his " Doctour of Plhvsik" was a uiniversity graduate; although it is difficult to-imagine that the typical practitioner in those days would have been a university nian.If. not a graduate, Clhaucer's appellation of "Doctour " may throw light on tlle origin of the courtesy title of "doctor"
Beware using secular trends in deaths to judge effectiveness of breast screening
Authors: D. H. Brewster, L. A. Bhatti, C. S. Thomson, D. A. Cameron, J. A. Dewar
Journal: BMJ (2013)

At least three papers have now used comparisons of secular trends in age specific mortality in breast cancer to make inferences about the effectiveness of mammographic screening.1 2 3 4 However, Autier et al were circumspect in their interpretation, acknowledging that the “larger reduction in mortality in women <50 years old may reflect better targeting of effective treatments and response to …
STUDIES ON THE VIRUS OF INFLUENZA
Authors: A. R. Dochez, K. C. Mills, Yale Kneeland
Journal: The Journal of Experimental Medicine (1936)

1. Evidence is presented indicating the presence of a filtrable virus in the nasopharyngeal secretions of individuals suffering from influenza. 2. An attempt to transfer influenza from one human being to another by means of filtered nasopharyngeal washings resulted in the production in the inoculated volunteer of a common cold. 3. A filtrable agent has been cultivated in tissue medium from the filtered nasopharyngeal washings of patients with influenza. 4. Inoculation of the cultivated virus into human volunteers results for the most part in the production of a severe common cold with a tendency to pronounced constitutional reaction. 5. In one instance following inoculation of culture virus an infection clinically resembling influenza has been produced. 6. The more closely the source of the virus approached the type of epidemic influenza, the more likely the virus was to provoke constitutional symptoms. 7. The presence of certain pathogenic bacteria in the upper respiratory tract of inoculated individuals was not observed to modify the course or character of the experimental infection. 8. On prolonged cultivation the virus loses the capacity to infect human volunteers.
Human neural stem cell intracerebral grafts show spontaneous early neuronal differentiation after several weeks
Authors: Annette Tennstaedt, Markus Aswendt, Joanna Adamczak, Ursel Collienne, Marion Selt, Gabriele Schneider, Nadine Henn, Cordula Schaefer, Marie Lagouge, Dirk Wiedermann, Peter Kloppenburg, Mathias Hoehn
Journal: Biomaterials (2015)

Human neural stem cells (hNSCs) hold great promise for the treatment of neurological diseases. Considerable progress has been made to induce neural differentiation in the cell culture in vitro and upon transplantation in vivo [2] in order to explore restoration of damaged neuronal circuits. However, in vivo conventional strategies are limited to post mortem analysis. Here, we apply our developed first fate mapping platform to monitor neuronal differentiation in vivo by magnetic resonance imaging, bioluminescence imaging, and fluorescence imaging. Ferritin, Luciferase and GFP under neuronal-specific promoters for immature and mature neurons, respectively, were used to generate transgenic hNSCs. Differentiation-linked imaging reporter expression was validated in vitro. The time profile of spontaneous neuronal maturation after transplantation into mouse brain cortex demonstrated early neuronal differentiation within 6 weeks. Fully mature neurons expressing synaptogenesis were observed only after three months or longer. Our trimodal fate mapping strategy represents a unique non-invasive tool to monitor the time course of neuronal differentiation of transplanted stem cells in vivo.