Cimetidine and Hematologic Effects
Authors: ROBERT RATE
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 November 1979Cimetidine and Hematologic EffectsROBERT RATE, M.D., MARK BONNELL, M.D., CAROL CHERVENAK, R.PH., GARY PAVINICH, R.PH.ROBERT RATE, M.D.Search for more papers by this author, MARK BONNELL, M.D.Search for more papers by this author, CAROL CHERVENAK, R.PH.Search for more papers by this author, GARY PAVINICH, R.PH.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-795 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent observations on the hematologic abnormalities (1-3) associated with cimetidine prompt us to report an additional case and to add two cautionary thoughts.A 53-year-old nonalcoholic Hopi woman with cryptogenic cirrhosis, suffered upper gastrointestinal bleeds in April 1978 and again in August 1979. Endoscopy revealed nonbleeding esophageal varices and superficially bleeding gastritis. After the April bleed, she was placed on cimetidine therapy, 300 mg orally every 6 h for 5 weeks. After the August bleed, she was restarted on cimetidine therapy, 300 mg orally every 8 h for 2 months. In December 1978 her platelet count was...References1. LITTLEJOHNUROWITZ GM. Cimetidine, lupus erythematosus, and granulocytopenia. Ann Intern Med. 1979;91:317-8. Letter. LinkGoogle Scholar2. MCDANIELSTEIN JJ. Thrombocytopenia with cimetidine therapy. N Engl J Med. 1979;300:864. Letter. CrossrefMedlineGoogle Scholar3. FRESTON J. Cimetidine and granulocytopenia. Ann Intern Med. 1979;90:264-5. Editorial. LinkGoogle Scholar4. HASTINGSSKILLMANBUSHNELLSILEN PJLW. Antacid titration in the prevention of acute Gastrointestinal bleeding: a controlled, randomized trial in 100 critically ill patients. N Engl J Med. 1978;298:1041-5. CrossrefMedlineGoogle Scholar5. IPPOLITISTURDEVANTISENBERG ARJ. Cimetidine versus intensive antacid therapy for duodenal ulcer: a multicenter trial. Gastroenterology. 1978;74:393-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Keams Canyon Indian Hospital Keams Canyon, AZ 86034 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCase Report: Oral Cimetidine Administration Causes Drug-Induced Immune Hemolytic Anemia by Eliciting the Production of Cimetidine-Dependent Antibodies and Drug-Independent Non-specific AntibodiesAntihistaminesAntihistaminesSystemic TherapyDrug-Induced Immune Hemolytic AnemiaIs cimetidine associated with neutropenia?Cimetidine-Induced Thrombocytopenia in a Cirrhotic PatientHaematological Adverse Effects of Histamine H2-Receptor AntagonistsCimetidine suppression of CFU-C in malesCimetidine-Associated ThrombocytopeniaHematologic Effects of CimetidineFORTUNATO V. ELIZAGA, M.D., ROBERT T.S. JIM, M.D., CARLOS B.C. LAM, M.D., STEVEN J. BERMAN, M.D.AntihistaminesDrug-induced Immune Haemolytic Anaemia 1 November 1979Volume 91, Issue 5Page: 795-795KeywordsCirrhosisEndoscopyGastritisHemorrhagePlatelets Issue Published: 1 November 1979 PDF DownloadLoading ...