tbuckley/cabot-search huggingface dataset:
STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT
Authors: Louise Pearce, Wade H. Brown
Journal: The Journal of Experimental Medicine (1923)

Several attempts were made to transplant a spontaneous malignant tumor in a syphilitic rabbit before a method was devised which proved successful. Subcutaneous and intracutaneous inoculations were unsuccessful on account of the vigorous granulomatous reaction which was aroused by the introduction of tumor fragments into these tissues. This difficulty was overcome by the use of intratesticular inoculations. With this method, a good growth was obtained in practically all animals. It appeared possible, however, that a syphilitic infection had been transmitted along with the tumor, and hence treatment with arsphenamine was instituted as a means of eliminating this infection. A study of the transplanted tumor in the first and second generations showed that it possessed a high degree of malignancy. Metastases occurred at an early period in the majority of animals, and while some of them appeared to recover, the indications were that more than 50 per cent might be expected to succumb to the effects of the tumor growth within a period of 6 to 7 months. The method of intratesticular inoculation now in use is described in detail.
Clinical Training for Students of Foreign Medical Schools in US Hospitals
Authors: Stan K. Sujka
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The concerns expressed by Signer and Crowley in their article<sup>1</sup>are quite valid, but the clinical training of foreign medical students in US hospitals is not as poorly supervised as the authors try to make us believe. To give you a personal example, I attended St George's University School of Medicine in Grenada and graduated in May 1982. My clinical rotations and electives were done in hospitals located in New York State. I worked alongside US-trained medical students. Not only did I find myself as well prepared as the US medical students for my clinical rotations, but I had no problem working and competing with them. In addition to being supervised by the same faculty that oversaw the US medical students, I was regularly supervised by St George's University. After each rotation, I was given a written examination administered by St George's University and proctored by
Bone marrow reticulin and collagen content in patients with adult chronic immune thrombocytopenic purpura: A Danish nationwide study
Authors: Marianne Schmidt Ettrup, Annette Østergaard Jensen, Malene Cramer Engebjerg, Dóra Körmendiné Farkas, Mette Nørgaard, Steven Cha, Sean Zhao, Preben Johansen, Henrik Toft Sørensen
Journal: American Journal of Hematology (2010)

We quantified and differentiated reticulin and collagen content in bone marrow specimens from chronic immune thrombocytopenic (ITP) patients and examined the correlation between some clinical characteristics and the fibrosis grading. Through the Danish National Patient Registry, we identified 378 patients with chronic ITP from 1997 until 2007. Of these, 253 (67%) had undergone at least one bone marrow biopsy, and we retrieved the bone marrow specimens from 187 (74%). We graded the bone marrow content of reticulin and collagen according to the Thiele scale (Grade 0-3). We also retrieved information on patients' clinical characteristics. We examined the prevalence of bone marrow fibrosis grading > 0 by patients' age (≤ 75 years and > 75 years), sex, platelet count at baseline (< 30 × 10⁹/L, and ≥ 30 × 10⁹/L), splenomegaly, hepatomegaly, and medications. In total 75 chronic ITP patients (40%) had a bone marrow grading >0. Of these, 72 (39%) had Grade 1 reticulin fibers present. Only three patients (< 2%) had collagen fibers present: two had Grade 2 and one had Grade 3. The prevalence of bone marrow grading > 0 was lower in patients aged > 75 years than ≤ 75 years (prevalence ratio = 0.64, 95% CI: 0.36-1.15) and lower in men than women (prevalence ratio = 0.70, 95% CI: 0.45-1.09), while a baseline platelet count ≥ 30 × 10⁹/L was associated with a higher prevalence of grading > 0 (prevalence ratio = 1.24, 95% CI: 0.81-1.86). Thus, bone marrow reticulin and collagen content in chronic ITP patients may be associated with some clinical characteristics.
Omitting the second person in social understanding
Authors: Vasudevi Reddy
Journal: Behavioral and Brain Sciences (1996)

Abstract Barresi &amp; Moore do not consider information about intentional relations available within emotional engagement with others and do not see that others are perceived in the second as well as the third person. Recognising second person information forces recognition of similarities and connections not otherwise available. A developmental framework built on the assumption of the complete separateness of self and other is inevitably flawed.
Novel allergic asthma model demonstrates ST2-dependent dendritic cell targeting by cypress pollen
Authors: Lucia Gabriele, Giovanna Schiavoni, Fabrizio Mattei, Massimo Sanchez, Paola Sestili, Cinzia Butteroni, Rita Businaro, Ananda Mirchandani, Wanda Niedbala, Foo Y. Liew, Claudia Afferni
Journal: Journal of Allergy and Clinical Immunology (2013)
The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model
Authors: Hau D. Le, Erica M. Fallon, Brian T. Kalish, Vincent E. de Meijer, Jonathan A. Meisel, Kathleen M. Gura, Vania Nose, Amy H. Pan, Bruce R. Bistrian, Mark Puder
Journal: Metabolism (2012)
Value of Positron Emission Tomography of the Para-Aortic Lymph Nodes in Cervical Carcinoma Stage IB2-IIIB
Authors: Ignace Vergote, Dimitris Tsolakidis, Dieter Mortier, Patrick Neven, Frederic Amant, Felix Mottaghy, Erik Van Limbergen
Journal: Journal of Clinical Oncology (2008)

active metabolite sirolimus that are not significantly different than those previously reported in RCC patients not receiving HD. 1,2 The authors also measured temsirolimus and sirolimus levels before and 1 hour after three HD sessions (data not shown).While it is difficult to interpret the data with respect to temsirolimus after the third HD session, as temsirolimus circulating levels at this time are quite low, their data suggest that HD does not substantially decrease circulating levels of either temsirolimus or sirolimus.It would be fitting to extend these observations to a larger number of patients.However, at the present time and in the absence of other data, these data suggest that in patients with metastatic RCC in whom temsirolimus may offer the best treatment option, such as in previously untreated patients at high risk (as defined by at least three of six risk factors including five Memorial Sloan-Kettering Cancer Center criteria 3 and multiple sites of metastasis) in whom temsirolimus has been shown to improve median overall survival, 4 and more broadly, in patients with non clear-cell RCC, and in particular papillary RCC, 5 for whom temsirolimus appears to be the most efficacious drug available in the market, temsirolimus may be administered regardless of whether the patient is on HD and no adjustments are needed in the dose or the regimen.
Effect of caffeine on maximal strength and power in élite male athletes.
Authors: B H Jacobson, M D Weber, L Claypool, L E Hunt
Journal: British Journal of Sports Medicine (1992)

Computerized testing of 20 élite male athletes was performed to determine the effect of 7 mg kg-1 caffeine on strength and power of the knee extensors and flexors. Subjects received counterbalanced administrations of either caffeine or a placebo on two separate occasions. Peak torque (T) was measured for knee extension (ET) and flexion (FT) at angular velocities of 30 degrees, 150 degrees and 300 degrees s-1. Additionally, performance for the first 125 ms (TAE) and power (W) were recorded during 300 degrees s-1. Testing sessions were held 1 week apart, at which time the placebo/caffeine administration was reversed. A 2 x 2 repeated measures analysis of variance supplemented with a Neuman-Keuls post hoc test showed the following--significant caffeine-related increases (P &lt; 0.05) for ET at 30 degrees s-1, ET at 300 degrees s-1, and ETAE, and EW at 300 degrees s-1. Dependent t-tests performed for pre- to post-test means showed significant changes for the caffeine group in ET at 30 degrees s-1, FT at 30 degrees s-1, FT at 150 degrees s-1, ET at 300 degrees s-1, FT at 300 degrees s-1, E and FTAE, and EW at 300 degrees s-1. No significant effects were found for the placebo trial in any variable. It was concluded that caffeine can favourably affect some strength parameters in highly resistance-trained males. However, differences in subject fibre type, motivation and caffeine sensitivity need to be elucidated.
Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow
Authors: Dan G. Duda, Rakesh K. Jain
Journal: Journal of Clinical Investigation (2005)

Recent evidence has demonstrated that endothelial-specific growth factors affect the development of apparently unrelated organs and cells. Expanding this evidence further, new findings in this issue of the JCI show that neurotrophic factors can affect neovascularization. Neurotrophic factors achieve proangiogenic effects not only by directly affecting endothelial cells, but also by recruiting hematopoietic precursors. Further understanding of the biology of angiogenic factors, as well as of the function of hematopoietic cells in tissue neovascularization, will lead to improved therapeutic strategies for the treatment of diseases ranging from ischemia to cancer.
Evaluation of Therapeutic Efficacy of Amantadine in Patients With Naturally Occurring A2 Influenza
Authors: Yasushi Togo
Journal: JAMA (1970)

Amantadine hydrochloride had a chemotherapeutic effect in patients with naturally occurring Asian influenza during the epidemic of 1967 to 1968. In double-blind clinical trials in which 54 men were treated with amantadine and 48 men received placebo capsules, more rapid defervescence and improvement of some symptoms were achieved in the drug-treated patients. The effect was demonstrable when drug therapy was started approximately 20 hours after the patients became ill. The causative virus was recovered at a high rate during the first four days of therapy in both groups which indicated that the drug did not affect virus shedding. Systemic as well as local antibody titer increases which developed in amantadine-treated patients during convalescence were equivalent to those of the placebo-treated patients.
A NEW SELF-RETAINING NASAL SPECULUM.
Authors: J. R. STRAW
Journal: JAMA (1896)

I have realized, as has I presume every other rhinologist, the need of an absolutely self-retaining nasal speculum, To obviate this, about two years ago I devised the instrument illustrated in the accompanying cuts. As an inventor is always an enthusiast on his own devices, I have hesitated to recommend it to the profession, fearing it would prove, as many other instruments, useless for its designed purpose. Knowing this fact, I have used it for the last two years, and am thoroughly satisfied as to its merits and practicability, especially for operations on the nose. Cut No. 1 represents the instrument with fenestrated blades, consisting of three, on a straight, square bar, those on either end being movable, the central stationary. This latter or central blade is placed on one side of the septum, while the dilating blade on the opposite side of the nose to be dilated, is brought
The Pharmacologic Basis of Thyroid Hormone Therapy.
Authors: Herbert A. Selenkow
Journal: Annals of Internal Medicine (1966)

s1 May 1966The Pharmacologic Basis of Thyroid Hormone Therapy.Herbert A. Selenkow, M.D., F.A.C.P., Marvin S. Wool, M.D.Herbert A. Selenkow, M.D., F.A.C.P.Search for more papers by this author, Marvin S. Wool, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1160_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThyroid hormones of animal origin have been used extensively for over 75 years despite several major therapeutic shortcomings. The United States Pharmacopeia (USP) requirements for pharmacologic standardization do not insure uniform hormonal content and thus different preparations of equal iodine content may have widely differing potencies. Synthetic L-thyroxine and L-triiodothyronine each have the distinct advantage of chemical purity but neither simulates all the physiologic actions of endogenous thyroid. L-thyroxine has a prolonged evanescent physiologic action and produces levels of protein-bound iodine (PBI) that are disproportionately high. Conversely, L-triiodothyronine has a rapid, brisk action and gives PBI levels that are quite... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Herbert A. Selenkow, M.D., F.A.C.P.; Marvin S. Wool, M.D.Affiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1160-1160KeywordsHormonal therapyProteinsThyroidThyroid hormonesThyroxineUnited States pharmacopeia ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...
A MODIFICATION OF PANAS' OPERATION FOR PTOSIS.
Authors: FRANK ALLPORT
Journal: JAMA (1903)

Panas' operation for ptosis probably yields better results, on the whole, than any other operation, and yet its various steps are not always clearly understood by operators, and it possesses some glaring defects that have served to render it rather unpopular. It is for the purpose of clearing up these misunderstandings and remedying the defects that I have ventured to offer this communication. I will first reproduce the drawings usually given to clarify the written description of Panas' operation, and it will be seen that they do not entirely clear up some of the points in the ordinary description. I think that the addition of a plain schematic drawing would better demonstrate the different steps in the operation, and for this purpose at my clinics I draw a plan like Figure 3. The line indicated by 1 represents the first incision, which should be in the eyebrow and extend to
Measures Used in the Prevention and Treatment of Cardiac Arrhythmias
Authors: Arthur J. Linenthal, Stone Freedberg
Journal: New England Journal of Medicine (1949)

THE management of cardiac arrhythmias is a common and important clinical problem. Although we shall not discuss diagnosis, it must be emphasized that accurate diagnosis of the nature of an arrhythmia is of the utmost importance since therapy useful in certain arrhythmias may be ineffective or harmful in others. In addition to reassurance, sedation, avoidance of possible precipitating factors (such as alcohol, caffeine, tobacco, emotion and exertion and the treatment of commonly associated diseases (such as acute myocardial infarction, infections and thyrotoxicosis), specific measures affecting the rate and rhythm of the heart may be indicated. A large number of drugs . . .
NEPHRITIS AND ITS INFLUENCE UPON HEMOGLOBIN PRODUCTION IN EXPERIMENTAL ANEMIA
Authors: G. H. Whipple, F. S. Robscheit-Robbins
Journal: The Journal of Experimental Medicine (1939)

Spontaneous glomerulonephritis develops not infrequently (11 per cent incidence) in the anemia colony. The course of the nephritis is insidious and usually extends over several years but ends in uremia, often with terminal bronchopneumonia. Hemoglobin production in these standard anemic dogs is well established as related to various standard food factors. These tests are summarized in the tables above to show the changes that appear year by year in the life of each dog. Nephritis causes little or no change in hemoglobin production in anemic dogs in the early stages of the disease. In the late stages of nephritis there may be no change or moderate changes in hemoglobin production in these anemic dogs. The average is 70 per cent of normal hemoglobin production in advanced nephritis. It seems unlikely that this degree of impairment of hemoglobin production in nephritis would result in spontaneous anemia in the dog.
China moves to change policy on child quotas
Authors: D. Payne
Journal: BMJ (1998)

A joint project between the United Nations and China is now under way in selected areas of the country that will replace the controversial system of birth quotas and enforced birth limits. The pilot project will replace quotas with sex education programmes and provide full information on contraceptives and sexually transmitted diseases.

The project began with virtually no publicity in February after receiving approval from the Chinese prime minister, Li Peng, …
Teen-zine sex is not all it seems
Authors: A. Mellanby
Journal: BMJ (1996)

Last week British media attention focused on the sexual content of magazines aimed at teenage girls as the Conservative MP for Worcester, Mr Peter Luff, promoted a private member's bill which would require their publishers to state a minimum age on the cover, thus enabling parents to judge whether the magazines are suitable for their teenagers.

Chatterbox, Sugar, It's Bliss, Catch, Mizz, Just Seventeen, More, and 19 are available from most newsagents, and the front covers of the February editions are more titillating than salacious and are heavily preoccupied with Valentine's day romance. Generally they do not give any clear idea of their intended target readership. Although Just Seventeen or 19 might be taken as titles indicating the target age, they are read by younger teenagers.

Without prior knowledge, teenagers must make their selection by trial and error, which is presumably the marketing strategy. Cover lines such as “Are you ready for sex? We ask your boy, your buddies … …
Correlation of Psychiatric Symptomatology and the Menstrual Cycle in an Outpatient Population
Authors: THEODORE J. JACOBS, EDWARD CHARLES
Journal: American Journal of Psychiatry (1970)

The authors studied the menstrual histories of 200 patients who had sought psychiatric help in order to determine the phase in which they came for help. The results demonstrated that the menstrual period, the premenstrual phase, and the midcycle intervals were the times of peak psychiatric contact. The authors discuss the significance of these findings to the management of certain types of psychiatric patients.
A Case of Parricide
Authors: J.L.Th.M. Vereecken
Journal: Psychotherapy and Psychosomatics (1965)

Case Reports| February 11 2010 A Case of Parricide Subject Area: Psychiatry and Psychology J.L.Th.M. Vereecken J.L.Th.M. Vereecken Leyden Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1965) 13 (5): 364–379. https://doi.org/10.1159/000285796 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J.L.Th.M. Vereecken; A Case of Parricide. Psychother Psychosom 1 May 1965; 13 (5): 364–379. https://doi.org/10.1159/000285796 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1965Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Impact of diuretic dosing on mortality in acute heart failure using a propensity‐matched analysis
Authors: Mehmet Birhan Yilmaz, Etienne Gayat, Reda Salem, Johan Lassus, Maria Nikolaou, Said Laribi, John Parissis, Ferenc Follath, W. Franck Peacock, Alexandre Mebazaa
Journal: European Journal of Heart Failure (2011)
Pneumomediastinum as a complication of athletic competition.
Authors: E J Morgan, D A Henderson
Journal: Thorax (1981)

An 8 year old child with tricuspid atresia had developed right sided pulmonary arteriovenous malformations following a previous classic Glenn procedure. These became clinically manifest immediately after Fontan conversion because of severe systemic desaturation. The pathophysiology and postoperative medical management of this case is described and related to current understanding of the aetiology of acquired pulmonary arteriovenous malformations following cavopulmonary shunt.
The Use of Radioiodinated Albumin in Metabolic Studies. The Effects of the Level of Dietary Protein and l-Triiodothyronine on the Catabolism of Radioiodinated Human Serum Albumin1
Authors: Frank L. Iber, Kurt Nassau, Irvin C. Plough, Florence M. Berger, William H. Meroney, Kenneth Fremont-Smith
Journal: Journal of Clinical Investigation (1958)
Early Experiences in the Treatment of Falciparum Malaria From Southeast Asia
Authors: William, P. Reed
Journal: JAMA (1968)

Four hundred and twenty-six patients had 859 episodes of malaria due to<i>Plasmodium falciparum</i>in late 1965. An analysis of the results of therapy reveals the following data: chloroquine was successful as treatment in 11% of the cases, quinine in 50%, chloroquine and quinine in 35%, pyrimethamine in 91%, quinine and pyrimethamine in 95%, and all three drugs combined in 80% Quinine alone was more effective, when used for 13 days or longer, than when used for 12 days or less. Chloroquine had a dose-related inhibitory effect on the success rate when combined with quinine. The best combination used was quinine and pyrimethamine.