Lymphoma, Hypercalcemia, and the Sunshine Vitamin
Authors: Malcolm Cox
Journal: Annals of Internal Medicine (1994)

Editorials1 November 1994Lymphoma, Hypercalcemia, and the Sunshine VitaminMalcolm Cox, MD and John G. Haddad, MDMalcolm Cox, MDVeterans Affairs Medical Center; Philadelphia, PA 19104Hospital of the University of Pennsylvania; Philadelphia, PA 19104 and John G. Haddad, MDVeterans Affairs Medical Center; Philadelphia, PA 19104Hospital of the University of Pennsylvania; Philadelphia, PA 19104Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-9-199411010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Under normal circumstances, parathyroid hormone and 1 α,25-dihydroxycholecalciferol (calcitriol) jointly defend the plasma calcium concentration. Parathyroid hormone increases renal distal tubular calcium reabsorption and mobilizes calcium from bone. Calcitriol, the active product of vitamin D metabolism, enhances gastrointestinal calcium absorption and also mobilizes calcium from bone. The roles of parathyroid hormone and calcitriol in calcium homeostasis are intimately interrelated. Parathyroid hormone is the primary trophic stimulator of renal 1 α-hydroxylase, the enzyme that converts 25-hydroxycholecalciferol into calcitriol. Calcitriol, in turn, inhibits parathyroid hormone secretion by at least two different mechanisms: direct repression of the preproparathyroid hormone gene and inhibition of ...References1. Moseley JM, Kubota M, Diefenbach-Jagger H, Wettenhall RE, Kemp BE, Suva LJ, et al. Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci U S A. 1987; 84:5048-52. Google Scholar2. Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna K, Weir EC, et al. 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IL-1 and tumor necrosis factor-α each up-regulate both the expression of IFN-γ receptors and enhance IFN-γ-induced HLA-DR expression on human monocytes and a human monocytic cell line (THP-1). J Immunol. 1993; 150:1205-11. Google Scholar Author, Article, and Disclosure InformationAuthors: Malcolm Cox, MD; John G. Haddad, MDAffiliations: Veterans Affairs Medical Center; Philadelphia, PA 19104Hospital of the University of Pennsylvania; Philadelphia, PA 19104Corresponding Author: Malcolm Cox, MD, Medical Service RF 111, Veterans Affairs Medical Center, University and Woodland Avenues, Philadelphia, PA 19104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCalcitriol Production in Hypercalcemic and Normocalcemic Patients with Non-Hodgkin Lymphoma John F. Seymour , Robert F. Gagel , Frederick B. Hagemeister , Meletios A. Dimopoulos , and Fernando Cabanillas Metrics Cited byHypercalcemia Due to Vitamin D ToxicityHHypercalcemia Due to Vitamin D ToxicityHypercalcemia and huge splenomegaly presenting in an elderly patient with B-cell non-Hodgkin's lymphoma: a case reportNOD/SCID mouse model of canine T-cell lymphoma with humoral hypercalcaemia of malignancy: cytokine gene expression profiling and in vivo bioluminescent imagingHypercalcemia Due to Vitamin D ToxicityMacronutrientsPathophysiology of Calcium, Phosphate, and Magnesium AbsorptionSymptomatic hypercalcemia in a diabetic patient undergoing continuous ambulatory peritoneal dialysis: Value of bone biopsy in the diagnosis and management 1 November 1994Volume 121, Issue 9Page: 709-712KeywordsCalcitriolCalciumHodgkin lymphomaHypercalcemiaLymphomaMacrophagesParathyroidParathyroid hormoneProteinsVitamin D ePublished: 15 August 2000 Issue Published: 1 November 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. 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