tbuckley/cabot-search huggingface dataset:
Unbundling: Neither Canny nor Fraud, Merely Unwitting
Authors: Paul M. Allen
Journal: JAMA (1990)

<h3>To the Editor. —</h3> The purpose of current procedural terminology<sup>1</sup>(CPT) coding—"to provide a uniform language that will accurately designate medical, surgical, and diagnostic services"—is necessary and understandable in this day of computer reimbursement of insurance claims. My worry is that this "uniform language" will go on to its logical conclusion, which is, like George Orwell's<sup>2</sup>Newspeak, to "make all other modes of thought impossible." Let's consider the term<i>unbundle</i>, which has recently become a buzzword in the context of CPT coding. Unbundling is the practice of coding a single procedure (a bundle) as a number of separate procedures. For example, a Total Hysterectomy (58150) might be coded as Exploration of the Abdomen (49000), Removal of Ovaries and Tubes (58720), Appendectomy (44955), and Lysis of Adhesions (58740). According to the CPT manual, this coding is incorrect, because all of these procedures are bundled together as Total Hysterectomy (58150).
New insights into pigmentary pathways and skin cancer
Authors: A.J. Miller, H. Tsao
Journal: British Journal of Dermatology (2009)

Journal Article New insights into pigmentary pathways and skin cancer Get access A.J. Miller, A.J. Miller Department of Dermatology, Mayo Clinic, Rochester, MN 55905, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar H. Tsao H. Tsao Wellman Center for Photomedicine, Department of Dermatology and MGH Melanoma and Pigmented Lesion Center/MGH Cancer Center, Massachusetts General Hospital, Boston, MA 02114, U.S.A. Hensin Tsao. E‐mail: htsao@partners.org Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 1, 1 January 2010, Pages 22–28, https://doi.org/10.1111/j.1365-2133.2009.09565.x Published: 01 January 2010
The Genetics of Drug Dependence: Tobacco Addiction
Authors: Neal L. Benowitz
Journal: New England Journal of Medicine (1992)

Most people experiment with cigarette smoking in childhood or adolescence. Why do some but not others become regular smokers? Most smokers in the United States say they would like to quit smoking. Why are some successful and others not? A central issue in understanding and treating drug dependence is the source of individual differences in the initiation and maintenance of drug use.Drug addiction is a complex process involving the interplay between the pharmacology of a psychoactive drug, family and peer influences, personality, existing psychiatric disorders, the cost and availability of the drug, the influence of advertising, and other factors. . . .
THE FAMILY INCIDENCE OF JUVENILE RHEUMATISM
Authors: N. G. Hill, M. Allan
Journal: BMJ (1930)

Applcectfion and Results.We ha-ve carried o0t the test on 380 patients at th& Obstetric Departmweu, Universitv College Hospital.-Thetest was done on fresh urine specimens, and the results are recorded in the following table : Duration of Pregnancy.
Cognitive versus Behavior Therapy: Processes of Change in the Treatment of Obsessive-Compulsive Disorder
Authors: Gideon E. Anholt, Pieter Kempe, Else de Haan, Patricia van Oppen, Danielle C. Cath, Johannes H. Smit, Anton J.L.M. van Balkom
Journal: Psychotherapy and Psychosomatics (2007)

&lt;i&gt;Background:&lt;/i&gt; Behavior therapy [exposure and response prevention (ERP)] and cognitive therapy (CT) have proven effective in the treatment of obsessive-compulsive disorder. Direct comparisons between these treatment modalities have exposed no differences in efficacy. However, very little research has been conducted into the differences between the change processes in ERP and CT. This investigation is a first attempt to study change by measuring scores on a weekly basis rather than at specific stages in the treatment and follow-up. &lt;i&gt;Methods:&lt;/i&gt; We used the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) at weekly intervals to rate and compare the severity of the obsessions and compulsions of 61 completers of either CT or ERP. The aim was to ascertain whether the process of change in CT is different from the process of change in ERP. We expected that ERP would primarily affect behavior, thus reducing compulsions first, while CT would primarily affect thought, thus reducing obsessions first. &lt;i&gt;Results:&lt;/i&gt; Firstly, no differences were found between ERP and CT with respect to the change process for obsessions and compulsions. Secondly, it emerged that changes in compulsions predicted all treatment effects better than changes in obsessions. &lt;i&gt;Conclusions:&lt;/i&gt; These results suggest that reduction of compulsions is the process through which both ERP and CT affect change.
Association of Geographic and Seasonal Variation With Diverticulitis Admissions
Authors: Lillias H. Maguire, Mingyang Song, Lisa L. Strate, Edward L. Giovannucci, Andrew T. Chan
Journal: JAMA Surgery (2014)

<h3>Importance</h3> The incidence of diverticulitis has been associated with geographic and seasonal variation. Low levels of circulating vitamin D are associated with diverticulitis. We investigated the association between UV light and diverticulitis. <h3>Observations</h3> We identified nonelective diverticulitis admissions in the Nationwide Inpatient Sample and linked hospital locations to UV data. We examined UV exposure in relation to risk of admission for diverticulitis. We identified geographic and seasonal trends among 226 522 nonelective admissions for diverticulitis. Compared with high-UV areas, low-UV areas had a higher rate of diverticulitis (751.8 vs 668.1 per 100 000 admissions;<i>P</i> &lt; .001), diverticular abscess (12.0% vs 9.7%;<i>P</i> &lt; .001), and colectomy (13.5% vs 11.5%;<i>P</i> &lt; .001). We also observed significant seasonal variation, with a lower rate of diverticulitis in the winter (645 per 100 000) compared with the summer (748 per 100 000) (<i>P</i> &lt; .001). The summer increase was more evident in areas with the greatest UV fluctuation vs areas with the least UV fluctuation (120 vs 70 per 100 000;<i>P</i> = .01). <h3>Conclusions and Relevance</h3> Low UV light exposure is associated with an increased rate of diverticulitis admissions and greater seasonal variation. Because UV exposure largely determines vitamin D status, these findings support a role for vitamin D in the pathogenesis of diverticulitis.
High mean platelet volume after myocardial infarction: is it due to consumption of small platelets?
Authors: R Sewell, R M Ibbotson, R Phillips, P Carson
Journal: BMJ (1984)

Seventy nine men surviving after sustaining a myocardial infarction in 1982, and who had at that time had raised mean platelet volumes compared with controls, were followed up after 18 months. The shape of each man9s platelet distribution curve was calculated from the mean platelet volume, platelet count, and platelet distribution width. The calculated curves were in close agreement with the curves plotted by the Coulter counter from the raw data. These curves did not differ significantly from those of a current control group, but the curves plotted from the variables measured at the time of myocardial infarction in 1982 showed a deficit of platelets in the volume range 5-12 fl amounting at maximum to 30% (p less than 0.0001); there were no significant differences above 12 fl. The deficit of small platelets became more appreciable during initial admission, was less at one month9s follow up, and had disappeared at one year. The deficit of small platelets is probably an effect rather than a cause of infarction.
TCT-707 Three-dimensional Echocardiographic Annular Sizing is Associated with Reduced Rates of Post-dilatation
Authors: Molly Forster, Omar K. Khalique, Susheel Kodali, Mathew Williams, Tamim Nazif, Jean-Michel Paradis, Isaac George, Kendra J. Grubb, Martin Leon, Rebecca Hahn
Journal: Journal of the American College of Cardiology (2013)
Chemical Meningitis Following Spinal Anesthesia
Authors: Robert B. Gibbons
Journal: JAMA (1969)

Meningitis occurred in three postpartum women within three to six hours following routine low spinal anesthesia. Infectious etiologies were excluded, and in each patient a diagnosis of chemical meningitis was established after finding evidence of contamination of needles and syringes by a detergent. All three patients were clinically well within three to four days, and no neurologic abnormalities were detected following recovery. Of interest was the occurrence of hypoglycorrhachia which was particularly severe in two of the patients.
Community medicine, community health
Authors: V R Rao
Journal: BMJ (1985)

admission was severity of symptoms or admission for social reasons.I found it surprising that there was no mention of pleural pain, since this is a relatively common reason for admission to hospital and in my experience prevents effective coughing in some patients.I am yet to be convinced of the value of physiotherapy in the treatment of primary pneumonia, but this paper has not caused me to question my present therapeutic practice of asking the physiotherapist to help expectoration in patients with pneumonia, especially those with pleural pain.
Demonstration of an Infected Popliteal (Baker??s) Cyst with Three-phase Skeletal Scintigraphy
Authors: ROBERT J. WALLNER, SIMIN DADPARVAR, MILLARD N. CROLL, LUTHER W. BRADY
Journal: Clinical Nuclear Medicine (1985)

A case is reported of an infected popliteal (Baker's) cyst demonstrated with triple phase skeletal scintigraphy. Although double-contrast arthrography and ultrasonography are currently the modalities most frequently employed to diagnose the presence of popliteal cysts, they may also be detected utilizing this radionuclide technique in the course of evaluation for knee joint disease or septic arthritis. Radionuclide studies may be more sensitive for the evaluation of associated inflammatory disease involving the knee joint.
160 HBV immunization after liver transplantation for HBV-related liver disease with conventional HBsAg vaccine during continuous HBIG administration: Low response rate, but universally applicable with low risk
Authors: N. Hooman, J. Rosenau, J. Hadem, M.J. Bahr, G. Philippe, J. Klempnauer, H.L. Tillmann, C.P. Strassburg, M.P. Manns
Journal: Journal of Hepatology (2006)
TCT-142 Thrombus aspiration is similarly effective in STEMI patients with ischemia lasting less than 6 hours compared to those with longer ischemia: subanalysis of the PATA STEMI trial
Authors: Dejan Orlic, Dejan Milasinovic, Milorad Zivkovic, Milorad Tesic, Vladimir Dedovic, Zlatko Mehmedbegovic, Branko Beleslin, Miodrag C. Ostojic
Journal: Journal of the American College of Cardiology (2014)
Distinct Patterns of Transforming Growth Factor-β Isoform and Receptor Expression in Human Atherosclerotic Lesions
Authors: Alex Bobik, Alex Agrotis, Peter Kanellakis, Rodney Dilley, Anatoly Krushinsky, Vladimir Smirnov, Eduard Tararak, Melanie Condron, Gina Kostolias
Journal: Circulation (1999)

Some animal studies suggest that transforming growth factor-beta (TGF-beta) protects vessels from atherosclerosis by preventing intima formation, but others indicate a role in vessel proteoglycan accumulation and lipoprotein retention. To distinguish between these possibilities in humans, immunohistochemical studies were performed examining the coexpression of TGF-beta isoforms and the TGF-beta receptors ALK-5 and TbetaR-II in aorta during the various stages of atherosclerotic lesion development.The spatial relationships between TGF-beta1, TGF-beta3, ALK-5, and TbetaR-II expression were compared in aortic segments from 21 subjects. Nonatherosclerotic intima contained predominantly TGF-beta1, low concentrations of TbetaR-II, and barely detectable amounts of ALK-5. In contrast, fatty streaks/fibrofatty lesions contained high concentrations of both TGF-beta isoforms. Smooth muscle cells (SMCs), macrophages, and foam cells of macrophage and SMC origin contributed to these high levels. These lesions also contained high, colocalized concentrations of ALK-5 and TbetaR-II. Despite fibrous plaques containing TGF-beta1, its receptors were at detection limits. We found no evidence for truncated TbetaR-II expression in either normal intima or the various atherosclerotic lesions.TGF-beta appears to be most active in lipid-rich aortic intimal lesions. The findings support the hypothesis that TGF-beta contributes primarily to the pathogenesis of lipid-rich atherosclerotic lesions by stimulating the production of lipoprotein-trapping proteoglycans, inhibiting smooth muscle proliferation, and activating proteolytic mechanisms in macrophages.
Relationship of Hemoglobin A1C and Mortality in Heart Failure Patients With Diabetes
Authors: David Aguilar, Biykem Bozkurt, Kumudha Ramasubbu, Anita Deswal
Journal: Journal of the American College of Cardiology (2009)

This study was designed to examine the relationship between glycosylated hemoglobin (HbA1C) and adverse outcomes in diabetic patients with established heart failure (HF). Despite the common coexistence of diabetes and HF, previous studies examining the association between HbA1C and outcomes in this population have been limited and have reported discrepant results. We assessed the association between increasing quintiles (Q1 to Q5) of HbA1C and risk of death or risk of HF hospitalization by conducting a retrospective study in a national cohort of 5,815 veterans with HF and diabetes treated in ambulatory clinics at Veterans Affairs medical centers. At 2 years of follow-up, death occurred in 25% of patients in Q1 (HbA1C ≤6.4%), 23% in Q2 (6.4% < HbA1c ≤7.1%), 17.7% in Q3 (7.1% < HbA1c ≤7.8%), 22.5% in Q4 (7.8% < HbA1c ≤9.0%), and 23.2% in Q5 (HbA1c >9.0%). After adjustment for potential confounders, the middle quintile (Q3) had reduced mortality when compared with the lowest quintile (risk-adjusted hazard ratio: 0.73, 95% confidence interval: 0.61 to 0.88, p = 0.001). Hospitalization rates for HF at 2 years increased with increasing quintiles of HbA1C (Q1: 13.3%, Q2: 13.1%, Q3: 15.5%, Q4: 16.4%, and Q5: 18.2%), but this association was not statistically significant when adjusted for potential confounders. The association between mortality and HbA1C in diabetic patients with HF appears U-shaped, with the lowest risk of death in those patients with modest glucose control (7.1% < HbA1C ≤7.8%). Future prospective studies are necessary to define optimal treatment goals in these patients.
The Metabolic Syndrome and Glucose Tolerance Status Deterioration Over 23-Year Follow-Up
Authors: Rachel S. Dankner, Angela Chetrit, Uri Goldbourt
Journal: Diabetes Care (2006)

those with IGT, 86.1% among subjects with IFG, 35.7% with "new" IFG, and 12.3% among subjects with normal glucose tolerance.The prevalence of metabolic syndrome increases with age, is higher in men than in women (26.5 vs. 18.3%, respectively, P ϭ 0.001), and is higher in rural than in urban areas (26.0 vs. 20.6%,respectively, P ϭ 0.037).The average daily energy intake was 2,509 kcal, to which carbohydrates contributed 53.3%, fats contributed 31.8%, and proteins contributed 14.9%.Comparing the OGTT(Ϫ) group with the three groups of various degrees of glucose intolerance, after age and sex adjustment, no differences were found regarding energy intake (range 2,551-2,231 kcal) or the qualitative composition of the diet (carbohydrates 53.1-54.9%,proteins 14.4 -15.4%, and fats 30.7-32.1%).Moreover, the above parameters did not differ between subjects with or without metabolic syndrome.In conclusion, the study revealed a very high prevalence of diabetes and IGT in Cyprus, among the highest in Europe, compared with five centers of the DECODE (Diabetes Epidemiology: Collaborative Analysis of Diagnostic Criteria in Europe) study (1) and higher than in the U.S. (2), while the prevalence of metabolic syndrome is comparable with that of other Western countries (3).Dietary habits, evaluated by cross-sectional analysis, do not seem to contribute to the development of glucose intolerance.Interventions aimed at IGT and the com-
Usefulness of 18F-FDG PET/CT in Disease Extent and Treatment Response Assessment in a Patient With Syphilitic Aortitis
Authors: Giorgio Treglia, Silvia Taralli, Fabio Maggi, Antonella Coli, Libero Lauriola, Alessandro Giordano
Journal: Clinical Nuclear Medicine (2012)

A 40-year-old man was admitted to our hospital for surgical treatment of aortic insufficiency and coronary ostial stenosis. Histopathology and serological tests revealed a syphilitic aortitis. F-FDG PET/CT was performed to assess the extent of aortitis, showing increased radiopharmaceutical uptake along the ascending aortic wall. A repeated FDG PET/CT after antibiotic therapy showed a markedly reduced uptake in the aortic wall, suggesting resolution of the infection according to clinical and serological data. This case highlights the usefulness of FDG PET/CT for the assessment of disease extent and treatment response in patients with syphilitic aortitis.
Evidence for the Renal Origin of the Malignant Phase of Essential Hypertension.
Authors: Gaddo Onesti
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Evidence for the Renal Origin of the Malignant Phase of Essential Hypertension.Gaddo Onesti, M.D., Kwan Eun Kim, M.D., (Associate), Albert N. Brest, M.D., F.A.C.P., Charles Swartz, M.D., F.A.C.P.Gaddo Onesti, M.D.Search for more papers by this author, Kwan Eun Kim, M.D., (Associate)Search for more papers by this author, Albert N. Brest, M.D., F.A.C.P.Search for more papers by this author, Charles Swartz, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-802_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSix uremic patients with malignant phase of essential hypertension were studied before and after bilateral nephrectomy. All patients had documented essential hypertension for 2 to 10 years. Histologic examination of all kidneys demonstrated malignant nephrosclerosis but no primary renal parenchymal disease or renal artery stenosis. The following values were measured twice a week before and after nephrectomy for 6 to 16 months: intra-arterial pressure, cardiac output, total peripheral resistance, blood volume, total exchangeable sodium, peripheral plasma renin. Diastolic blood pressure averaged 158 mm Hg before nephrectomy and 93 mm Hg after nephrectomy. The decrease in blood pressure after nephrectomy was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 802-802KeywordsBlood pressureBlood volumeCardiac outputHypertensionKidneysNephrectomyRenal arteriesRenal diseasesSodiumStenosis Issue Published: 1 May 1970 PDF DownloadLoading ...
Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome
Authors: Junji Xu, Dandan Wang, Dayong Liu, Zhipeng Fan, Huayong Zhang, Ousheng Liu, Gang Ding, Runtao Gao, Chunmei Zhang, Yaozhong Ding, Jonathan S. Bromberg, Wanjun Chen, Lingyun Sun, Songlin Wang
Journal: Blood (2012)
The conceptual structure of the integrated exposure uptake biokinetic model for lead in children.
Authors: P D White, P Van Leeuwen, B D Davis, M Maddaloni, K A Hogan, A H Marcus, R W Elias
Journal: Environmental Health Perspectives (1998)

The integrated exposure uptake biokinetic model for lead in children was developed to provide plausible blood lead distributions corresponding to particular combinations of multimedia lead exposure. The model is based on a set of equations that convert lead exposure (expressed as micrograms per day) to blood lead concentration (expressed as micrograms per deciliter) by quantitatively mimicking the physiologic processes that determine blood lead concentration. The exposures from air, food, water, soil, and dust are modeled independently by several routes. Amounts of lead absorbed are modeled independently for air, food, water, and soil/dust, then combined as a single input to the blood plasma reservoir of the body. Lead in the blood plasma reservoir, which includes extracellular fluids, is mathematically allocated to all tissues of the body using age-specific biokinetic parameters. The model calculation provides the estimate for blood lead concentration for that age. This value is treated as the geometric mean of possible values for a single child, or the geometric mean of expected values for a population of children exposed to the same lead concentrations. The distribution of blood lead concentrations about this geometric mean is estimated using a geometric standard deviation, typically 1.6, derived from the analysis of well-conducted community blood studies.
New Italian Institute
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermoscopic rainbow pattern in non-Kaposi sarcoma lesions - reply
Authors: S-T. Cheng, C-L.K. Ke, C-H. Lee, C-S. Wu, G-S. Chen, S.C-S. Hu
Journal: British Journal of Dermatology (2009)

Conflicts of interest: none declared. Madam, We read with great interest the correspondence by Vázquez‐López et al.1 regarding the dermoscopic observation of the rainbow pattern in non‐Kaposi sarcoma (non‐KS) lesions. We would like to emphasize that our previous study was based on seven patients with KS and 63 patients with various other cutaneous vascular tumours and nonvascular tumours.2 In our study, we did not observe the dermoscopic rainbow pattern in the non‐KS tumours, indicating that the rainbow pattern is highly specific for KS lesions. However, we do not in any way claim that the dermoscopic rainbow pattern is completely specific for KS, and it is possible that non‐KS lesions may produce the rainbow pattern under dermoscopy. In their correspondence, Vázquez‐López et al. showed three possible images of the rainbow pattern in three different skin lesions: nail melanoma, stasis dermatitis and lichen planus. We find it surprising that the rainbow pattern could be seen in melanoma lesions. It is known that numerous studies have been performed on the dermoscopic features of melanoma, and none have ever mentioned the appearance of the rainbow pattern under dermoscopy.3 4–5 A large‐scale study using polarized dermoscopy to observe lesions of melanoma would be more helpful to determine whether the rainbow pattern is indeed a dermoscopic feature of melanoma. In addition, we would like to suggest that the rich vascular network of the nail bed may itself be responsible for the rainbow pattern, rather than the tumour itself.6