tbuckley/cabot-search huggingface dataset:
Quantitative assessment of aortic regurgitation by colour flow Doppler in an open chest canine model
Authors: E. K LOUIE, I. KRUKENKAMP, R. J HARIMAN, S. LEVITSKY
Journal: Cardiovascular Research (1989)

Journal Article Quantitative assessment of aortic regurgitation by colour flow Doppler in an open chest canine model Get access ERIC K LOUIE, ERIC K LOUIE **From the Cardiology Section, Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, USA Address for correspondence and reprints: Eric K Louie MD, Associate Professor of Medicine, Section of Cardiology, Department of Medicine, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL 60153, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar IRVIN KRUKENKAMP, IRVIN KRUKENKAMP †From the Division of Cardiothoracic Surgery, Department of Surgery, University of Illinois College of Medicine, Chicago, Illinois, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT J HARIMAN, ROBERT J HARIMAN **From the Cardiology Section, Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar SIDNEY LEVITSKY SIDNEY LEVITSKY †From the Division of Cardiothoracic Surgery, Department of Surgery, University of Illinois College of Medicine, Chicago, Illinois, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 23, Issue 2, February 1989, Pages 145–151, https://doi.org/10.1093/cvr/23.2.145 Published: 01 February 1989 Article history Accepted: 04 October 1988 Published: 01 February 1989
The effects of sodium ricinoleate on small intestinal function and structure.
Authors: W S Cline, V Lorenzsonn, L Benz, P Bass, W A Olsen
Journal: Journal of Clinical Investigation (1976)

The mechanism of hydroxy fatty acid-induced secretion was investigated in perfused hamster small intestine in vivo. Sodium ricinoleate at an 8-mM concentration resulted in not only secretion of water and sodium, but an increase in intestinal clearance of inulin and a 16,000 mol wt dextran as well. A concentration of ricinoleate (2 mM) which did not affect water transport, however, did not alter intestinal permeability. Ricinoleate-induced intestinal secretion was also accompanied by increased mucosal cell exfoliation as measured by the appearance of DNA in the perfusate and by apparent injury to epithelial cell membranes as judged by measurement of sucrase activity and phospholipid in cell-free aliquots of luminal fluid. Light and electron microscopic studies demonstrated substantial mucosal architectural changes with 8 mM ricinoleate with villus shortening and injury to epithelial cells at the villus tips. In contrast, cholera enterotoxin caused marked secretion of sodium and water, presumably by a cyclic AMP mechanism, but did not alter inulin clearance or enhance DNA or sucrase appearance in the lumen. These studies suggest that at least a component of ricinoleate-induced intestinal secretion is related to structural alterations of the mucosa.
PHASE ANALYSIS IN PATIENTS WITH WOLFF-PARKINSON-WHITE SYNDROME BEFORE AND AFTER PHARMACOLOGICAL INTERVENTION
Authors: M. Hourani, D. Kayden, L. Zaman, F. Lanas, A. Castellanos, R. Myerburg, C. Lopez, G. Sfakianakis, A. Serafini
Journal: Clinical Nuclear Medicine (1983)

Hourani, M.; Kayden, D.; Zaman, L.; Lanas, F.; Castellanos, A.; Myerburg, R.; Lopez, R.; Sfakianakis, G.; Serafini, A.Author Information
Intraosseous Lipoma in the Femoral Shaft Mimicking a Bone Metastasis on Bone Scintigraphy
Authors: Myung-Hee Sohn, Seok Tae Lim, Hwan-Jeong Jeong, Dong Wook Kim, Kyu Yun Jang, Chang-Yeol Yim
Journal: Clinical Nuclear Medicine (2009)

Primary intraosseous lipoma is a rare benign neoplasm of mature fat cells arising within the bone marrow, most commonly within the metaphysis of long bones. Involvement of the epiphysis or diaphysis is uncommon. An intraosseous lipoma typically shows no abnormal uptake of a bone-seeking agent. Bone scintigraphy demonstrated a focal area of uptake in the right femoral shaft mimicking a bone metastasis in a 52-year-old man with basal cell carcinoma of the face. Plain radiography showed a well-defined radiolucent lesion with endosteal erosion in the intramedullary portion. MRI showed no fat tissue in the lesion. Histology confirmed intraosseous lipoma with dystrophic calcification and myxomatous degeneration.
IL-22 Administration Decreases Intestinal Gvhd Pathology, Increases Intestinal Stem Cell Recovery, and Enhances Immune Reconstitution Following Allogeneic Hematopoietic Transplantation
Authors: Anna M Mertelsmann, Jarrod A Dudakov, Enrico Velardi, Guoqiang Hua, Fabiana M Kreines, Emily R Levy, Margaret O'Connor, Odette M Smith, Richard Kolesnick, Marcel R. M. van den Brink, Alan M Hanash
Journal: Blood (2013)
Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery.
Authors: E A Neuwelt, K R Maravilla, E P Frenkel, S I Rapaport, S A Hill, P A Barnett
Journal: Journal of Clinical Investigation (1979)

The present study describes a canine model of transient reversible blood-brain barrier disruption with hyperosmolar mannitol infusion into the internal carotid artery. Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in markedly elevated (therapeutic) levels of drug in the ipsilateral cerebral hemisphere. Levels in the cerebrospinal fluid correlate poorly and inconsistently with brain levels. Computerized tomograms in this canine model provide a noninvasive monitor of the degree, time-course, and localization of osmotic blood-brain barrier disruption.
Abstract LB-276: A novel approach using the telomerase-selective adenoviral marker (OBP-401) for detection of circulation tumor cells in breast cancer patients
Authors: Seung Jin Kim, Jun Sato, Tetsuya Taguchi, Yasuhiro Tamaki, Fumine Tsukamoto, Kenji Akazawa, Akinori Masago, Yukio Tsujino, Yasuo Urata, Shinzaburo Noguchi
Journal: Cancer Research (2010)

Abstract Background: The detection of circulating tumor cells (CTCs) is a potential method to predict survival of metastatic breast cancer patients as well as outcomes of early breast cancer patients. However, no method for CTCs has yet proven to be the golden standard. We developed a new approach for detecting CTCs using the telomerase-selective adenoviral marker (OBP-401, Oncolys Biopharma). This marker contains the replication cassette, in which the human telomerase reverse transcriptase promoter drives expression of E1 genes, and the green fluorescent protein (GFP) gene for monitoring viral replication. Thus, OBP-401 infects viable cancer cells and replicates in them under the telomerase activity, and we can detect viable CTCs as GFP-positive cells. Methods: This system is consisted of the following steps; (1) virus-infection for 7.5 ml whole blood (incubated with 4 × 10sup8 Plaque Forming Unit OBP-401 virus for 24 hours at 37 Celsius), (2) dead cell staining using L23102 (invitrogen), (3) virus-inactivation and RBC elimination, and (4) detection of GFP expressing cells using fluorescence microscopy. In a preclinical study, the sensitivity of this system was assessed using cell lines. Next, we conducted feasibility studies for CTCs detection in 80 healthy individuals, 70 metastatic, and 27 early breast cancer patients. In metastatic and early breast cancer patients, we compared the sensitivity of this system with that of CellSearch® (Veridex). GFP-positive cells (viable CTCs) and L23102 expressing cells measuring ≥ 20 m in diameter (dead CTCs) were considered as CTCs in this system. Preliminary data: The sensitivity of this system, which was determined by a serial dilution of MDA-MB-468 cells against healthy volunteer's blood, was 1 cell per 7.5 ml. Neither viable nor dead CTCs were detected in any of healthy controls. Of 50 metastatic patients, 12% were primary breast cancers with stage IV disease, 24% were in the 1st line chemotherapy setting, and 42 % were heavily pretreated with chemotherapy. The sensitivities of tumor markers (CEA and CA15-3), CellSearch, and OBP-401 were 78%, 54%, and 66%, respectively. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-276.
Prevalence of Hepatitis C Virus Infection in Hemodialysis Patients: A Longitudinal Study Comparing the Results of RNA and Antibody Assays
Authors: Tak Mao Chan, Anna Suk Fong Lok, Ignatius Kum Po Cheng, Rachel Tzun Chan
Journal: Hepatology (1993)

We longitudinally studied 51 patients from two hemodialysis centers to determine the prevalence of hepatitis C virus infection in hemodialysis patients. Serum samples were tested for antibody to HCV by first- and second- generation enzyme immunoassays and for hepatitis C virus RNA by nested polymerase chain reaction assay. Antibody to hepatitis C virus was detected in the initial serum samples by first-generation enzyme immunoassay and second-generation enzyme immunoassay in 6 (11.8%) and 11 (21.6%) patients, respectively. First-generation enzyme immunoassay had a false-positive rate of 33.3% and a false-negative rate of 63.6%. Hepatitis C virus RNA was found in eight second-generation enzyme immunoassay–positive patients (72.7%) and in one patient negative for antibody to hepatitis C virus (2.5%) giving an overall positivity rate of 17.6%. After 19 mo, antibody to hepatitis C virus was detected in 15 patients (29.4%) on second-generation enzyme immunoassay; hepatitis C virus RNA was found in 13 patients (25.5%). Hepatitis C virus markers persisted in all 12 patients with initial evidence of hepatitis C virus infection. Three patients acquired hepatitis C virus infection during the interim, giving a new infection rate of 4.9% per patient-year. Antibody to hepatitis C virus, hepatitis C virus RNA or both was detected in 55.6% of patients with biochemical changes suggestive of non-A, non-B hepatitis. Of the 15 antibody to hepatitis C virus, second-generation enzyme immunoassay-positive patients, 66.7% had persistently normal serum transaminase levels. In summary, hepatitis C virus infection is common among hemodialysis patients. First-generation enzyme immunoassay is an unreliable assay for antibody to hepatitis C virus in these patients. We found good correlation between the results of antibody to hepatitis C virus detection on second-generation enzyme immunoassay and of hepatitis C virus RNA by nested polymerase chain reaction and found that serum transaminase level is a poor indicator of hepatitis C virus infection in hemodialysis patients. (HEPATOLOGY 1993;17:5–8.)
EXAMINATION FOR AMEBIASIS
Authors: Anthony Bassler
Journal: JAMA (1934)

<h3>To the Editor:—</h3> The special articles on the outbreak of amebiasis in Chicago are most commendable. In a recent one you suggest that the stools should be examined one month after cessation of treatment, the inference being that if the results are negative the patient is cured and parasite free. In my experience with this disorder I have found that one cannot be sure that the patient is parasite free (which condition should be accomplished if possible) without this being judged by examinations made four times in the year after the cessation of treatment. At one month after active treatment the stools usually are free from the vegetative forms and so few cysts are present that they are not found. For each of these third month examinations (in the absence of symptoms) the gravitation or sedimentation methods for cysts are the most important, and these will often disclose the carrier.
NEW ANAEROBIC METHODS
Authors: Wilson G. Smillie
Journal: The Journal of Experimental Medicine (1917)

1. Anaerobic methods have been devised which depend upon the catalytic action of platinized asbestos upon hydrogen and oxygen. 2. The methods may be utilized for the growth of anaerobes in test-tubes, upon Blake bottles, in flasks, and in a large container. 3. Because oxygen is so completely removed, the methods are of great value in the successful cultivation of absolute anaerobes.
300 SERPINB3 AND TGF-β1 CORRELATION IN CHRONIC LIVER DISEASE
Authors: C. Turato, F. Calabrese, A. Biasiolo, S. Quarta, M. Ruvoletto, N. Tono, L. Franzosi, D. Paccagnella, G. Fassina, A. Gatta, P. Pontisso
Journal: Journal of Hepatology (2009)
Molecular and metabolic basis for the metabolic disorder normotriglyceridemic abetalipoproteinemia.
Authors: D A Hardman, C R Pullinger, R L Hamilton, J P Kane, M J Malloy
Journal: Journal of Clinical Investigation (1991)

We have previously described a disorder, normotriglyceridemic abetalipoproteinemia, that is characterized by the virtual absence of plasma low density lipoproteins and complete absence of apoB-100, but with apparently normal secretion of triglyceride-rich lipoproteins containing apoB-48. The patient's plasma lipoproteins were shown on polyacrylamide gels and by antibody mapping to have a new truncated apoB variant, apoB-50, circulating along with her apoB-48. We have found this individual to be homozygous for a single C-to-T nucleotide substitution at apoB codon 2252, which produces a premature in-frame stop codon. Thus, this is a rare example of homozygous hypobetalipoproteinemia. Electron photomicrographs revealed that the diameters of particles in the d less than 1.006 g/ml lipoprotein fraction, in both the postprandial and postabsorptive state, are bimodally distributed. The molar ratio of apoE to apoB in these particles is 3.5:1, similar to normal VLDL. The plasma LDL interval contains both spherical and cuboidal particles. Autologous reinfusion of labeled d less than 1.006 g/ml lipoproteins showed exponential disappearance from plasma, with an apparent half-removal time of 50 min, somewhat slower than for normal chylomicrons but within the normal range for VLDL. The calculated production rate for apoB was within the normal range in this subject. A very small amount of label was found briefly in the IDL fraction, but none at any time in LDL or HDL. Therefore, because LDL particles that contain apoB-50 lack the putative ligand domain of the LDL receptor, we conclude that the very low level of LDL is due to the rapid removal of the abnormal VLDL particles before their conversion to LDL can take place.
Therapy of Osteoarthritis Of the Great Toe
Authors: David Abrahamsen
Journal: JAMA (1973)

To the Editor.—  I would like to report the treatment of a woman suffering from postoperative osteoarthritis, with keloid formation and fibrosis and contracture of the metatarsophalangeal joints of both feet, especially of the hallux joint with apparent ankylosis.  She had undergone surgery twice, unsuccessfully, within a year for hallux rigidus and hallux valgus, respectively. The result was that the feet were inflamed, swollen, and she was unable to walk. While desperately looking for help, I happened to see inThe Journal(217:215, 1971) a letter by Dr. Marvin Steinberg in which he recommended injections for such a condition. As prescribed by Dr. Steinberg, I administered injections of hyaluronidase and lidocaine around the joints and in the scarred areas for approximately two years. Initially, this treatment was done twice a week, but progressively less frequently until two months ago when treatment ceased.  The result has been most gratifying in that
JEWISH HYGIENE AND DIET, THE TALMUD AND VARIOUS OTHER JEWISH WRITINGS HERETOFORE UNTRANSLATED.
Authors: C. H. VON KLEIN
Journal: JAMA (1884)

[Read in Section of State Medicine and Hygiene of the American Medical Association, May 1884 ] We are now in the age of pride and the Niobe of nations. But when we look back even to the dark age of the Egyptians, we find that our sanitary measures are far behind any other advancements of modern civilization. Hygeia, commonly called the goddess of health, and from which the term hygiene has its etymology, was a pretender, as well as her father Esculapius,who styled himself the god of medicine. But when we look back beyond the days of those pretenders, we find that nations lived hundreds of years before them, whose literature was ever preserved by a nation which has preserved itself and survived nations of ordinary power. When the Egyptians strove amongst themselves, their literature was destroyed, and the loss of the library of Alexandria is felt at the present
Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction.
Authors: J E Buring, G T O'Connor, S Z Goldhaber, B Rosner, P N Herbert, C B Blum, J L Breslow, C H Hennekens
Journal: Circulation (1992)

A large and consistent body of evidence supports the judgment that elevation of total plasma blood cholesterol is a cause of myocardial infarction (MI) and that high levels of low density lipoprotein (LDL) cholesterol have a positive relation and high levels of high density lipoprotein (HDL) cholesterol an inverse relation with MI. At present, however, the roles, if any, of the major subfractions of HDL, namely, HDL2 and HDL3, have not been clarified. In addition, the relation of plasma apolipoprotein concentrations to MI and whether they provide predictive information over and above their lipoprotein cholesterol associations is unknown.We evaluated these questions in a case-control study of patients hospitalized with a first MI and neighborhood controls of the same age and sex. Cases had significantly lower levels of total HDL (p less than 0.0001) as well as HDL2 (p less than 0.0001) and HDL3 (p less than 0.0001) cholesterol. These differences persisted after controlling for a large number of demographic, medical history, and behavioral risk factors and levels of other lipids. There were significant (p less than 0.0001) inverse dose-response relations with odds ratios for those in the highest quartile relative to those in the lowest of 0.15 for total HDL, 0.17 for HDL2, and 0.29 for HDL3 cholesterol levels. Levels of LDL and very low density lipoprotein cholesterol and triglycerides were also higher among cases than controls, but only for triglycerides was the difference statistically significant after adjustment for coronary risk factors and other lipids (p = 0.044). Apolipoproteins A-I and A-II were both significantly (p less than 0.0001) lower in cases, and differences remained even after adjustment for coronary risk factors and lipids. There were significant dose-response relations for both apolipoprotein A-I (p = 0.026) and A-II (p = 0.002). Neither apolipoprotein B nor E was significantly related to MI after adjustment for lipids and other coronary risk factors. When all four apolipoproteins were taken together, there was an increased level of prediction of MI over the information provided by the lipids and other coronary risk factors (p = 0.003), but this appeared present only for the individual apolipoproteins A-I (p = 0.027) and A-II (p = 0.011).These data indicate that both HDL2 and HDL3 cholesterol levels are significantly associated with MI. They also raise the possibility that apolipoprotein levels, especially A-I and A-II, may add importantly relevant information to determination of risk of MI.
RELATIONSHIP BETWEEN ERECTILE DYSFUNTION AND CORONARY ARTERY CALCIFICATION IN A POPULATION OF MIDDLE AGED MEN IN THE WORLD TRADE CENTER MEDICAL MONITORING AND TREATMENT PROGRAM.
Authors: Sima J. Patel, Mary Ann A. McLaughlin, Boback M. Berookhim, Rupa L. Iyengar, Danielle R. Platt, Simonette T. Sawit, Jaqueline M. Moline, Natan Bar-Chama
Journal: Journal of the American College of Cardiology (2010)
Mechanism of propranolol withdrawal phenomena.
Authors: S Nattel, R E Rangno, G Van Loon
Journal: Circulation (1979)

Nine patients on chronic treatment with propranolol for essential hypertension for 3 months or longer were studied after abrupt discontinuation of the drug. Each patient demonstrated transient supersensitivity to the chronotropic effects of isoproterenol, beginning 2--6 days (median 4 days) after propranolol withdrawal, lasting for 3--13 days (median 6 days), with the maximum sensitivity on day 6. A significantly lower dose of isoproterenol was necessary to increase heart rate 25 beats/min on day 6 (median dose 1.2 microgram, range 0.3--3.4 microgram) compared with after day 14, when sensitivity had stabilized (median dose 2.3 microgram, range 1.4--7.6 microgram). Six patients had transient symptoms (headache, chest pain, palpitations and sweating) after abrupt propranolol withdrawal, coinciding with supersensitivity to isoproterenol in five. Transient increases in plasma catecholamines and blood pressures and sustained increases in heart rate occurred during the period of isoproterenol supersensitivity in most patients, and may have contributed to symptoms noted. The delayed onset and potentially long duration of beta-adrenergic supersensitivity after abrupt propranolol withdrawal have important clinical implications.
Salicylate-induced consumption coagulopathy.
Authors: H M Pinedo, L B van de Putte, E A Loeliger
Journal: Annals of the Rheumatic Diseases (1973)

Raised serum transaminase levels injuvenile rheumatoid arthritis (JRA) treated with salicylates have been reported by Russell, Sturge, and Smith (1971).The present communication describes a second complication apparently coinciding with this sign of liver injury during administration of salicylates. MethodsSerum transaminases were determined according to the method ofKarmen, Wrobleski, and La Due (1955) (normal values for our laboratory: SGOT and SGPT up to 15 i.u./ litre), serum salicylate levels with Trinder's reagent, fibrinogen according to the method of Clauss (1957), fibrinogen degradation products (FDP) by the immuno- diffusion technique (Ouchterlony), and Factor V according to the method of Borchgrevink, Pool, and Stormorken (1960).Case report A 15-year-old boy was referred to the Leiden University Medical Centre.During hospitalization elsewhere he had been treated for suspected rheumatic fever with salicylates in doses up to 6 g. daily for 2 weeks, and 3 days before his admission at Leiden, the excision of a lymph node from the right axilla (histology: non-specific inflammation) had resulted in profuse bleeding requiring five blood trans- fusions (2,500 ml.).Thrombocytopenia had been demon- strated (thrombocytes 20,000 per p1.).Salicylates had been discontinued 2 days before admission and replaced by high doses of corticosteroids.In spite of this treatment the .patient'sgeneral condition deteriorated. ExaminationHe was a pale sick boy, slightly jaundiced, with enlarged non-tender lymph nodes in the neck and left axilla, hepato- splenomegaly, and a (transient) macular rash over the trunk.Body temperature 36 7°C., pulse rate 35 (a tran- sient, unexplained sinus bradycardia), respiration rate 16, blood pressure 120/80 mm.Hg, and body weight 41 2 kg.In the right axilla there was a surgical wound
Training for Rural Practice
Authors: R. H. Shackelford
Journal: JAMA (1974)

<h3>To the Editor.—</h3> In an article entitled "Training in a Small Town for Rural Practice" (225:1103, 1973), Dr. Harrell writes as a medical educator about the construction in a rural town of a unit to be used as a teaching vehicle in the training of students and residents in rural practice. A unit is already functioning that meets most of the criteria set out by Dr. Harrell. Our unit has sufficient space to accommodate three to four physicians. Currently, two physicians employ three full-time receptionists, a secretary, a bookkeeper, an insurance clerk, a part-time dietician, three licensed practical nurses, a pediatric nurse-practitioner, a physician's assistant, a laboratory technician, an x-ray technician, and two high school girls as aides. Nine examining rooms, an emergency room, a laboratory, and an x-ray unit handle 600 to 700 office visits weekly. Facilities for pulmonary function studies, electrocardiography, cardiac monitoring, local anesthesia, minor surgery, direct