Ranitidine and Agranulocytosis
Authors: Linda I. Shields, Julia A. Files, Donald C. Doll, Bernard R. Greenberg
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 January 1986Ranitidine and AgranulocytosisLINDA I. SHIELDS, M.D., JULIA A. FILES, M.D., DONALD C. DOLL, M.D., BERNARD R. GREENBERG, M.D.LINDA I. SHIELDS, M.D.Search for more papers by this author, JULIA A. FILES, M.D.Search for more papers by this author, DONALD C. DOLL, M.D.Search for more papers by this author, BERNARD R. GREENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-1-128_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The H2-receptor antagonist ranitidine hydrochloride (Zantac; Glaxo, Inc. , Research Triangle Park, North Carolina) has been used extensively for the treatment of gastrointestinal disorders. While serious blood dyscrasias have been reported with the use of cimetidine (1), no cases of agranulocytosis have been documented with ranitidine. We report a case of agranulocytosis following the administration of ranitidine for treatment of duodenitis.A 53-year-old man was hospitalized for evaluation of leukopenia and a 1-week history of fever, sore throat, and diarrhea. One month before admission the patient had started therapy with ranitidine, 150 mg twice daily, for treatment...References1. FRESTON J. Cimetidine and granulocytopenia [Editorial]. Ann Intern Med. 1979;90:264-5. LinkGoogle Scholar2. HERRERASOLAL-CELIGNYDRESCHVALLINBERNADES APCJP. Ranitidine [Letter]. N Engl J Med. 1984;310:1604-5. Google Scholar3. HARMONSHUMAN DR. Ranitidine [Letter]. N Engl J Med. 1984;310:1604. Google Scholar4. LIMA M. Hepatitis associated with ranitidine. Ann Intern Med. 1984;101:207-8. LinkGoogle Scholar5. BYRON J. Pharmacodynamic basis for the interaction of cimetidine with the bone marrow stem cells (CFUs). Exp Hematol. 1980;89:256-63. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LINDA I. SHIELDS, M.D.; JULIA A. FILES, M.D.; DONALD C. DOLL, M.D.; BERNARD R. GREENBERG, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLa leucocitopenia en pacientes tratados con clozapina puede estar inducida por otros fármacos: una serie clinicaLeukopenia in clozapine treated patients may be induced by other drugs: a case seriesNeutropenia in the Neonatal Intensive Care UnitTransient, Profound Thrombocytopenia in a Premature Infant: Is this a Ranitidine-Induced Immune Reaction?Thrombocytopenia Secondary to Prophylactic Use of Ranitidine HydrochlorideAcute Eosinophilic Pneumonia Associated with RanitidineOrganisms in Rock Bed Contact-purification Channel for Improvement of Eutrophic Coastal Water.Cimetidine-Induced Myelosuppression After Bone Marrow TransplantationMechanism of Ranitidine Associated AnemiaReversible Hematologic Suppression during Ranitidine TreatmentAgranulocytosis after ranitidine administrationRanitidine Fails to Suppress the Growth in vitro of Haemopoietic Progenitors from Human Peripheral Blood or Bone MarrowHaematological Adverse Effects of Histamine H2-Receptor AntagonistsRanitidine-Induced Granulocytopenia: Recurrence with Cimetidine AdministrationALAN F. LIST, M.D., DAVID H. BEAIRD, M.D., THOMAS KUMMET, M.D.Safety perspectives on parenteral H2-receptor antagonistsClinically Important Adverse Effects and Drug Interactions with H 2 -Receptor Antagonists: An UpdateGastrointestinal drugs 1 January 1986Volume 104, Issue 1Page: 128-128KeywordsBloodDiarrheaFeversPharyngitis ePublished: 1 December 2008 Issue Published: 1 January 1986 PDF downloadLoading ...