tbuckley/cabot-search huggingface dataset:
Abstract 4100: YM-155 sensitizes malignant human glioma cells to ABT-737 via survivin and Mcl-1 downregulation in an EGFR-dependent context.
Authors: Esther P. Jane, Daniel Premkumar, Joseph DiDomenico, Bo Hu, Shi-Yuan Cheng, Ian Pollack
Journal: Cancer Research (2013)

Abstract Antiapoptotic proteins are commonly overexpressed in gliomas, contributing to therapeutic resistance. We recently showed that clinically achievable concentrations of the Bcl-2/Bcl-xL inhibitor ABT-737 failed to induce apoptosis in glioma cells, with persistent expression of survivin and Mcl-1. To address the role of these mediators in glioma apoptosis resistance, we analyzed the effects of YM-155, a survivin suppressant, on survival on a panel of glioma cell lines. YM-155 inhibited growth, and downregulated survivin and Mcl-1 in a dose- and cell line-dependent manner. Whereas U373, LN18, LNZ428, T98G, LN229, and LNZ308 cells exhibited an IC50 of 10-75 nM, A172 cells were resistant (IC50 ∼ 250 nM). No correlation was found between sensitivity to YM-155 and baseline expression of survivin or cIAP-1/cIAP-2/XIAP. However, strong correlation was observed between EGFR activation levels and YM-155 response, which was confirmed using EGFR-transduced versus wild-type cells. Because we postulated that decreasing Mcl-1 expression may enhance glioma sensitivity to ABT-737, we examined whether cotreatment with YM-155 promoted ABT-737 efficacy. YM-155 synergistically enhanced ABT-737-induced cytotoxicity and caspase-dependent apoptosis. Down-regulation of Mcl-1 using shRNA also enhanced ABT-737-inducing killing, confirming an important role for Mcl-1 in mediating synergism between ABT-737 and YM-155. As with YM-155 alone, sensitivity to YM-155 and ABT-737 Citation Format: Esther P. Jane, Daniel Premkumar, Joseph DiDomenico, Bo Hu, Shi-Yuan Cheng, Ian Pollack. YM-155 sensitizes malignant human glioma cells to ABT-737 via survivin and Mcl-1 downregulation in an EGFR-dependent context. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4100. doi:10.1158/1538-7445.AM2013-4100
Symptoms, signs and findings in humans exposed to PCBs and their derivatives.
Authors: G Reggiani, R Bruppacher
Journal: Environmental Health Perspectives (1985)

The records of the health effects caused by some accidental exposure and findings from medical examination in cases exposed to polybrominated biphenyls (PBB) as well as to polychlorinated biphenyls (PCB) and their derivatives polychlorinated dibenzofurans (PCDF) and dibenzodioxins (PCDD) have provided some information for the recognition and classification of their toxicity in humans. The most impressive clinical features have been presented by the yusho episode of exposure. Dermatologic signs are the most persistent indicator of a considerable uptake. Neurological symptoms, respiratory findings and impairment of liver function are further aspects of the contamination. Skin manifestations have been observed also in the newborn infants from mothers exposed to high levels of the substances. However, the available data make it still hard to assess the clinical picture of the effects on humans in cases of acute exposure and even more the effects on reproduction and long-term effects. Furthermore it would still be arbitrary to draw a line between the symptoms which can be referred to PCBs and PBBs alone and those which can be related qualitatively and quantitatively to PCB derivatives (PCDFs, PCDDs, PCQs).
Soya supplements do not protect against postmenopausal changes
Authors: Scott Gottlieb
Journal: BMJ (2004)

Soya supplements containing naturally occurring oestrogen do not improve cognitive function, bone mineral density, or plasma lipids in healthy postmenopausal women, a new study says ( JAMA 2004;292: 65-74).

The sudden decline in oestrogen levels after menopause coincides with the acceleration of several ageing processes, but because of the side effects of hormone replacement therapy some women have turned to naturally occurring oestrogens known as phytoestrogens (including isoflavones and lignans) that occur in plant foods such as soya beans, peas, fruit, vegetables, nuts, and grains.

In the study, Dr …
Process improvement and comparability analysis for engineered T cell manufacture
Authors: Luca Melchiori, Martin Kreutz, Daniel Williams, Gwendolyn Binder-Scholl, On Kan, David Moss, Bent Jakobsen
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Engineered T cell therapy (ECT) for oncology has met significant clinical proof of success for chemotherapy resistant B cell malignancies in multiple studies. These data have underscored the transformative potential of ECT in advanced oncology. Adaptimmune specializes in the
Urine Bacterial Counts after Sexual Intercourse
Authors: R. Michael Buckley, Maryanne McGuckin, Rob Roy MacGregor
Journal: New England Journal of Medicine (1978)

THE association between sexual intercourse and subsequent acute symptomatic urinary-tract infection in women is so well known that these episodes are often labeled "honeymoon cystitis." Trauma to the relatively short female urethra during intercourse, allowing the bacteria that colonize the introitus to ascend to the urinary bladder, has been invoked to explain the association. Because recurrent urinary-tract infection in women is a perplexing problem for both doctor and patient, various measures have been proposed to prevent recurrences, ranging from scrubbing the perineum before intercourse to emptying the bladder soon after. The effectiveness of such methods has not been documented. Vosti . . .
Metallic Mercury Embolism to the Hand
Authors: Antonio Carlos de Souza, Adelino Moreira de Carvalho
Journal: New England Journal of Medicine (2009)

Severe pain developed in the left hand of a 46-year-old woman after open heart surgery was performed to repair an atrial septal defect. It was initially thought that this pain was due to a thrombosis associated with a pressure-monitoring device in her left radial artery. Physical examination showed erythematous lesions, cyanosis, and ischemia of her left hand (Panel A). Radiographic findings revealed radiopaque particles (Panel B, black and white arrows) that were consistent with the presence of mercury in the soft tissues of her hand. The particles most likely came from the manometer used with the arterial line (a common . . .
Pure human minigastrin: secretory potency and disappearance rate
Authors: H. T. Debas, J. H. Walsh, M. I. Grossman
Journal: Gut (1974)

Minigastrin, a gastrin with 13 amino-acid residues, was recently isolated from tissues by Gregory and Tracy (1974). In this study, pure human natural nonsulphated minigastrin (HG-13-I) and pure human natural nonsulphated heptadecapeptide gastrin (HG-17-I) were compared with regard to acid-stimulating potency and rate of disappearance from blood. Three dogs with gastric fistulae and Heidenhain pouches were given these gastrins by continuous intravenous infusion in doses of 100, 200, 400, and 800 pmol/kg-hr. Equimolar infusion rates of HG-13-I and HG-17-I caused equimolar increases over basal of serum immunoreactive gastrin but HG-13-I- was less than half as potent as HG-17-I in stimulating acid secretion (potency ratio 0·4, 95% confidence limits 0·2 to 0·6). The half time for disappearance of HG-13-I from blood was 1·8 minutes and its volume of distribution was calculated to be 0·17 1/kg, values similar to those found for HG-17-I in an earlier study. The role of minigastrin in health and disease awaits further study.
Comparison of the Bleeding Potential of Vampire Bat Salivary Plasminogen Activator Versus Tissue Plasminogen Activator in an Experimental Rabbit Model
Authors: Michelle Montoney, Stephen J. Gardell, Victor J. Marder
Journal: Circulation (1995)

Background Vampire bat salivary plasminogen activator (Bat-PA) has significantly greater fibrin specificity than any of the fibrinolytic agents currently in clinical use. This study tests the hypothesis that avoiding fibrinogen depletion may protect against the hemorrhage induced by plasminogen activator treatment. Methods and Results Bat-PA was compared with tissue-type plasminogen activator (TPA) in a randomized, prospective, and blinded study using a rabbit ear puncture model of fibrinolytic bleeding. The two agents were used at equimolar dosages (42 nmol/kg) that yielded similar thrombolytic efficacies in a rabbit femoral artery thrombosis model. Both Bat-PA and TPA prolong primary bleeding to double the baseline values, from between 2.1 and 2.3 minutes to between 4.8 and 5.2 minutes. Rebleeding from hemostatically stable sites during the 3-hour observation period occurred equally often with Bat-PA and TPA, 31% from preinjection sites and 23% to 25% from postinjection sites. The lag time between the time of plasminogen activator injection and the onset of rebleeding was likewise the same for both agents, most occurring at 41 to 57 minutes. However, a greater number of prolonged primary or rebleeding occurrences continued for longer than 10 minutes (63% versus 36%) or longer than 30 minutes (30% versus 10%) after Bat-PA than TPA injection. Animals treated with TPA showed a dramatic decrease in plasma fibrinogen and factor VIII concentrations, but those in the Bat-PA treatment group showed only a slight decrease from control values. Conclusions The results indicate that fibrinolytic bleeding after plasminogen activator infusion into rabbits did not correlate with the intensity of the plasma proteolytic state. If anything, Bat-PA usage was associated with a higher proportion of more protracted fibrinolytic bleeding episodes, despite the relatively mild lytic state in comparison with that induced by TPA.
JAMA Editorial Position and US Health System Reform
Authors: Sydney G. Bild
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Dr Lundberg's<sup>1</sup>wish list for US health system reform rests on belief in a nonexistent medical marketplace. The actual marketplace is a classic example of supply-side economics. Practicing physicians, one component of the actual marketplace, set their own fees in a way not to threaten those of their colleagues. There are practically no market pressures that would lower prices. When we physicians order tests, prescribe drugs, or schedule procedures, it is the rare patient who can effectively raise objections. The actual marketplace has placed physicians' incomes in the top 1% of incomes in the nation. Lundberg rates the single-payer health plan zero on the physician-liability question. The truth is that the single-payer plan would eliminate large awards for out-of-pocket health care expenses for iatrogenic disabilities, and this fact alone should lower liability insurance costs. But the major problem in the Editorial is the uncritical approach taken
Prevalance of proteinuria in Mexico: A conjunctive consolidation approach with other cardiovascular risk factors: The Mexican Health Survey 2000
Authors: Martin Rosas, Fause Attie, Gustavo Pastelin, Agustin Lara, Oscar Velazquez, Roberto Tapia-Conyer, Jesus Martinez-Reding, Arturo Mendez, Antonio Lorenzo-Negrete, Jaime Herrera-Acosta
Journal: Kidney International (2005)
A NEW TENACULUM FORCEPS.
Authors: OLIVER C. SMITH
Journal: JAMA (1904)

While in Paris last summer, I saw an instrument made by Collin, which struck me at once as being an excellent substitute for the pressure forceps, where this is used to grasp and hold the margins of delicate tissues, as the peritoneum, the pleura, the incised walls of visceræ, the bladder, stomach, intestines, etc. The instrument was a delicately made straight tenaculum forceps, similar to the Croenlein forceps, with five interdigitating teeth; two on one jaw, three on the other, and provided with French lock and ratchet clasp. I brought some of them home, but found on using that the teeth projected and scratched the tissues. This led me to modify the instrument by providing it with two diverging teeth, 1¾ mm. in length on the upper jaw, and with a flat ovoid platform with two perforations on the under jaw. I also gave the instrument a
Integrating Neglected Tropical Diseases into AIDS, Tuberculosis, and Malaria Control
Authors: Peter J. Hotez, Neeraj Mistry, Joanna Rubinstein, Jeffrey D. Sachs
Journal: New England Journal of Medicine (2011)

We can improve the lives of the world's poorest people by incorporating low-cost, rapid-impact packages of drugs for neglected tropical diseases into ongoing programs for the control of HIV–AIDS, tuberculosis, and malaria.
Synthesis of Thyroid Hormone.
Authors: N. J. Nadler
Journal: Annals of Internal Medicine (1962)

s1 April 1962Synthesis of Thyroid Hormone.N. J. Nadler, M.D., Ph.D.N. J. Nadler, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-677_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe thyroid gland is made up of individual follicles in each of which there is a single layer of epithelial cells surrounding a lumen. In the lumen is contained the so-called colloid which is composed predominantly of a mucoprotein, thyroglobulin. Within the framework of this thyroglobulin molecule, the synthesis of thyroid hormones, thyroxine and triiodothyronine, takes place.Since leucine is a prominent amino acid of thyroglobulin, it has been possible to trace the synthesis of thyroglobulin in follicles by means of radioautographs prepared from fixed histological sections of thyroid glands obtained at various times after the administration of leucine labelled... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 677-677KeywordsAmino acidsEpithelial cellsHormone synthesisLeucineStainingThyroglobulinThyroidThyroid hormonesThyroxineTriiodothyronine Issue Published: 1 April 1962 PDF DownloadLoading ...
Pediatric Electrocardiography: Normal and Abnormal Patterns, Incorporating the Vector Approach
Authors: Donald C. Fyler
Journal: JAMA (1966)

This monograph was designed as an introduction to electrocardiography with emphasis on pediatric experience. The subject matter ranges from sublimely theoretical considerations to the day-to-day methods of reporting and classification. The author provides useful practical points regarding the electronics and physics of electrocardiographic equipment. Arrhythmias and myocardial infarction are superficially covered since these are scarcely large problems in pediatrics. The recognition of ventricular hypertrophy is the main concern. While a great amount of material has been compressed for the sake of brevity, the author maintains a lucid style. Interwoven and openly stated is the persuasive philosophic approval of electrocardiography. The illustrations are notable for their clarity and are not hypothetical drawings. Electrocardiograms and vectorcardiograms from the same patient are presented on the same page for comparison. Throughout, the vector approach is utilized to explain the electrocardiographic record. Concise rules for the interpretation of patterns are presented. There will always be
Extent of Gene Duplication in the Genomes of Drosophila, Nematode, and Yeast
Authors: Zhenglong Gu, Andre Cavalcanti, Feng-Chi Chen, Peter Bouman, Wen-Hsiung Li
Journal: Molecular Biology and Evolution (2002)

We conducted a detailed analysis of duplicate genes in three complete genomes: yeast, Drosophila, and Caenorhabditis elegans. For two proteins belonging to the same family we used the criteria: (1) their similarity is > or =I (I = 30% if L > or = 150 a.a. and I = 0.01n + 4.8L(-0.32(1 + exp(-L/1000))) if L < 150 a.a., where n = 6 and L is the length of the alignable region), and (2) the length of the alignable region between the two sequences is > or = 80% of the longer protein. We found it very important to delete isoforms (caused by alternative splicing), same genes with different names, and proteins derived from repetitive elements. We estimated that there were 530, 674, and 1,219 protein families in yeast, Drosophila, and C. elegans, respectively, so, as expected, yeast has the smallest number of duplicate genes. However, for the duplicate pairs with the number of substitutions per synonymous site (K(S)) < 0.01, Drosophila has only seven pairs, whereas yeast has 58 pairs and nematode has 153 pairs. After considering the possible effects of codon usage bias and gene conversion, these numbers became 6, 55, and 147, respectively. Thus, Drosophila appears to have much fewer young duplicate genes than do yeast and nematode. The larger numbers of duplicate pairs with K(S) < 0.01 in yeast and C. elegans were probably largely caused by block duplications. At any rate, it is clear that the genome of Drosophila melanogaster has undergone few gene duplications in the recent past and has much fewer gene families than C. elegans.
Single-dose Therapy with Streptomycin and Sulfametopyrazine for Bacteriuria during Pregnancy
Authors: J. D. Williams, E. K. Smith
Journal: BMJ (1970)

One hundred and sixty-three patients with bacteriuria in pregnancy were treated with a single dose of antibiotic. Four regimens were used: sulfadoxine (sulphormethoxine) 2 g., sulfametopyrazine 2 g., streptomycin 1 g., and a combination of sulfametopyrazine 2 g. and streptomycin 1 g. The highest cure rate of 77% was achieved with streptomycin and sulfametopyrazine. The long-acting sulphonamides alone gave a cure rate of 55% while streptomycin alone eradicated 43% of the infections. Despite the high cure rate with combined therapy bacterial resistance developed in some cases.
Comment on Schmitz et al. Recurrent Subthreshold Depression in Type 2 Diabetes: An Important Risk Factor for Poor Health Outcomes. Diabetes Care 2014;37:970–978
Authors: Jori Aalders, Frans Pouwer
Journal: Diabetes Care (2014)

A recent prospective study by Schmitz et al. (1) concluded a dose-response relationship between recurrent (subthreshold) depressive symptoms and impaired functioning and impaired health-related quality of life (HRQoL) in participants ( n = 1,064) with type 2 diabetes during five annual follow-up assessments. The results of this study confirm that (subthreshold) depressive symptoms are common and highly recurrent in type 2 diabetes (2). This is of general concern, as depression in type 2 diabetes is strongly associated with not only suboptimal quality of life but also a 1.5-fold increased mortality risk (3). However, we have some concerns about the assessment of HRQoL, one of …
By how much does dietary salt reduction lower blood pressure? III--Analysis of data from trials of salt reduction.
Authors: M R Law, C D Frost, N J Wald
Journal: BMJ (1991)

OBJECTIVE--To determine whether the reduction in blood pressure achieved in trials of dietary salt reduction is quantitatively consistent with estimates derived from blood pressure and sodium intake in different populations, and, if so, to estimate the impact of reducing dietary salt on mortality from stroke and ischaemic heart disease. DESIGN--Analysis of the results of 68 crossover trials and 10 randomised controlled trials of dietary salt reduction. MAIN OUTCOME MEASURE--Comparison of observed reductions in systolic blood pressure for each trial with predicted values calculated from between population analysis. RESULTS--In the 45 trials in which salt reduction lasted four weeks or less the observed reductions in blood pressure were less than those predicted, with the difference between observed and predicted reductions being greatest in the trials of shortest duration. In the 33 trials lasting five weeks or longer the predicted reductions in individual trials closely matched a wide range of observed reductions. This applied for all age groups and for people with both high and normal levels of blood pressure. In people aged 50-59 years a reduction in daily sodium intake of 50 mmol (about 3 g of salt), attainable by moderate dietary salt reduction would, after a few weeks, lower systolic blood pressure by an average of 5 mm Hg, and by 7 mm Hg in those with high blood pressure (170 mm Hg); diastolic blood pressure would be lowered by about half as much. It is estimated that such a reduction in salt intake by a whole Western population would reduce the incidence of stroke by 22% and of ischaemic heart disease by 16% [corrected]. CONCLUSIONS--The results from the trials support the estimates from the observational data in the accompanying two papers. The effect of universal moderate dietary salt reduction on mortality from stroke and ischaemic heart disease would be substantial--larger, indeed, than could be achieved by fully implementing recommended policy for treating high blood pressure with drugs. However, reduction also in the amount of salt added to processed foods would lower blood pressure by at least twice as much and prevent some 75,000 [corrected] deaths a year in Britain as well as much disability.
Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil
Authors: Camila Alexandrina Figueiredo, Maurício Lima Barreto, Neuza Maria Alcantara-Neves, Laura Cunha Rodrigues, Philip John Cooper, Alvaro A. Cruz, Lain Carlos Pontes-de-Carvalho, Denise C. Lemaire, Ryan dos Santos Costa, Leila D. Amorim, Candelaria Vergara, Nicholas Rafaels, Li Gao, Cassandra Foster, Monica Campbell, Rasika A. Mathias, Kathleen C. Barnes
Journal: Journal of Allergy and Clinical Immunology (2012)
Prevalence of Metabolic Syndrome in Rural Bangladeshi Women
Authors: M. Mostafa Zaman, Jasimuddin Ahmed, Sohel R. Choudhury, Sharkar Md. Numan, Md. Sadequl Islam, Kawsar Parvin
Journal: Diabetes Care (2006)

The National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) (1) defined metabolic syndrome as a presence of any three of the following (in women): 1 ) waist circumference >88 cm, 2 ) high triglycerides (≥150 mg/dl), 3 ) low HDL cholesterol (<50 mg/dl), 4 ) high blood pressure (≥130/85 mmHg or use of antihypertensive therapy), and 5 ) high fasting blood glucose (≥110 mg/dl). This clustering of risk factors in metabolic syndrome ultimately leads to diabetes and premature cardiovascular disease (2). It is imperative to identify individuals with metabolic syndrome early so that lifestyle interventions and treatment may prevent the development of diabetes and/or cardiovascular diseases. The aim …