tbuckley/cabot-search huggingface dataset:
Transmitral pulsed‐Doppler echocardiography is a more accurate technique compared with two‐dimensional echocardiography using dobutamine, in patients with one vessel coronary artery disease
Authors: Gani Bajraktari, Spiro Qirko, Rossana Fusco, Angela Milazzo, Brunilda Xhaxho, Antonio Pezzano
Journal: European Journal of Heart Failure (2003)
Acquired Methemoglobinemia in an Infant Due to Benzocaine Suppository
Authors: Hart de C. Peterson
Journal: New England Journal of Medicine (1960)

IN the following case methemoglobinemia in an infant was due to rectal absorption of benzocaine:Case ReportE.M.. a 21-day-old infant, was referred to the Boston City Hospital because of deep cyanosis. He had been born at another hospital 23 days before the expected day of confinement, after 12 hours of labor preceded by 24 hours of ruptured membranes. Pregnancy was otherwise normal. The birth weight was 2.5 kg. (1/2 00BDounds, 7/2 ounces). His stay in the nursery was unremarkable, and he was discharged at 4 days of age.One week before admission, a diaper rash developed, and the family . . .
Polyarthritis complicating quinidine treatment.
Authors: P Kertes, D Hunt
Journal: BMJ (1982)

clinical reader and honorary consultant neurolo- gist Polyarthritis complicating quinidine treatmentWe describe a case of reversible, symmetrical polyarthritis that developed secondary to quinidine treatment.To our knowledge this complication has not previously been reported. Case reportA 33-year-old Australian man underwent aortic valve replacement with a St Jude medical valve in March 1980 for rheumatic aortic regurgitation.After the operation he developed recurrent atrial fibrillation and flutter, which eventually settled with digoxin and a long-acting quinidine bisulphate preparation (Kinidin Durules).Soon after starting quinidine he described on 19 August
Hyperproliferation of PKD1 cystic cells is induced by insulin-like growth factor-1 activation of the Ras/Raf signalling system
Authors: E. Parker, L.J. Newby, C.C. Sharpe, S. Rossetti, A.J. Streets, P.C. Harris, M.J. O'Hare, A.C.M. Ong
Journal: Kidney International (2007)
Mechanism for acute oral desensitization to antibiotics
Authors: H.‐Y. Woo, Y.‐S. Kim, N.‐I. Kang, W.‐C. Chung, C.‐H. Song, I.‐W. Choi, I.‐H. Choi, H.‐K. Lee
Journal: Allergy (2006)

Background: Despite the widespread use of an acute oral desensitization procedure in patients with allergic reactions to a variety of antibiotics, the precise mechanism of this procedure is poorly understood. Objective: To investigate the mechanisms underlying acute oral desensitization to antibiotics. Methods: Using a murine model of active systemic anaphylaxis to penicillin V (Pen V), mice previously sensitized to Pen V were desensitized by oral feeding of Pen V. The dose was doubled every 15 min and five feedings were given. The achievement of acute oral desensitization was evaluated by induction of active systemic and active cutaneous anaphylaxis, and by measuring the plasma levels of platelet‐activating factor and histamine. Antigen‐specific serum IgE antibody (Ab) levels were determined by passive cutaneous anaphylaxis. Results: Mice fed more than 3 mg of cumulative dose of Pen V were completely protected from fatal systemic anaphylactic reaction and the desensitized state lasted approximately 1 h. Antigen‐specific mast cell desensitization, but not hapten inhibition, consumption of IgE Abs, or depletion of mast cell mediators, occurred during acute oral desensitization. Conclusions: Acute oral desensitization to Pen V occurred in the mice, and antigen‐specific mast cell desensitization was associated with the underlying mechanism for oral desensitization.
Gamma‐chain heterogeneity of fetal hemoglobin in nonblack β‐ and δβ‐thalassemia and hpfh heterozygotes and homozygotes
Authors: G. D. Efremov, B. Ibarra, A. Gurgey, P. K. Sukumaran, C. Altay, T. H. J. Huisman
Journal: American Journal of Hematology (1982)

Abstract The fetal hemoblobin (Hb F) of a few hundred nonblack patients with a heterozygosity or homozygosity for β‐thalassemia (β‐thal), δβ‐thalassemia (δβ‐thal), and some forms of the hereditary persistence of Hb F (HPFH) was isolated by DEAE‐cellulose chromatography and further characterized by high‐pressure liquid chromatography. Quantitative data for the three types of γ chain ( A γ T , A γ I , and G ‐γ) were compared with those obtained for the Hb F from black patients with similar conditions. The G γ chain levels in nonblack β‐thal heterozygotes varied greatly and did not fall into two distinct groups with high or low levels, as has been observed in blacks. The level of the A γ T chain in A γ T heterozygotes did not differ significantly when this anomaly was in cis or in trans to the β‐thal determinant. Beta‐thalassemia homozygotes from Turkey and Yugoslavia, had G γ values varying between 40% and 80%. Only 13 of 34 patients carried the A γ T gene. Nine were A γ T heterozygotes with an A γ T /total A γ level averaging 39% and four were A γ T homozygotes. The G γ chain levels in nonblack δβ‐thal heterozygotes varied between 28% and 46%. An additional A γ T chain heterozygosity in cis to the δβ‐thal determinant demonstrated that over 90% of the γ chains is produced by genes in cis to this anomaly. Analyses of members of two relatively large families with β‐thal, δβ‐thal, and the A γ T chain heterozygosities and homozygosities occurring in different combinations allowed a more or less quantitative evaluation of the production of γ‐chain genes in cis or in trans to either of the two types of thalassemia determinants. Such calculations were possible both in simple heterozygotes and in persons with the β‐δβ‐thalassemia condition.
Quinidine and Rheumatic Syndromes
Authors: Frank R. Schmid
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 August 1988Quinidine and Rheumatic SyndromesFrank R. Schmid, MDFrank R. Schmid, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-3-247_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Cohen and colleagues (1) carefully analyzed seven patients who had a rheumatic syndrome after treatment with quinidine. The data that would support the emergence of two distinct syndromes are unclear.A more reasonable interpretation would be that the three patients with polyarthropathy alone had a milder form of the illness than the other four patients. This interpretation is supported by the generally lower dose of quinidine used and the prompter resolution of disease in the polyarthropathy group than in the group receiving the higher dose. The briefer latency period for the arthropathy group may represent the fortuitous...Reference1. CohenKevatProwseAhern MSMM. Two distinct quinidine-induced rheumatic syndromes. Ann Intern Med. 1988;108:369-71. LinkGoogle Scholar1. CohenKevatProwseAhern MSMM. Two distinct quinidine induced rheumatic syndromes. Ann Intern Med. 1988;108:369-71. LinkGoogle Scholar2. LeeChase SP. Drug-induced systemic lupus erythematosus: a critical review. Semin Arthritis Rheum. 1976;5:83-103. CrossrefGoogle Scholar3. ShalitFlugelmanHaratsGalunAckermanKopolovicEliakim MMNEZJM. Quinidine-induced vasculitis. Arch Intern Med. 1985;145:2051-2. CrossrefMedlineGoogle Scholar4. HarmonPortanova CJ. Drug-induced lupus: clinical and serological studies. Clin Rheum Dis. 1982;8:121-35. CrossrefMedlineGoogle Scholar5. Perry H. Late toxicity to hydralazine resembling systemic lupus erythematosus or rheumatoid arthritis. Am J Med. 1973;54:58-72. CrossrefMedlineGoogle Scholar1. CohenKevatProwseAhern MSMM. Two distinct quinidine-induced rheumatic syndromes. Ann Intern Med. 1988;108:369-71. LinkGoogle Scholar2. KertesHunt PD. Polyarthritis complicating quinidine treatment. Br Med J [Clin Res]. 1982;284:1373-4. CrossrefMedlineGoogle Scholar3. NaschitzYeshurun JD. Quinidine induced sicca syndrome. J Toxicol Clin Toxicol. 1983;20:367-71. CrossrefMedlineGoogle Scholar4. KarenLasagna FL. Adverse drug reactions: a critical review. JAMA. 1975;234:1236-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Northwestern University Medical School Chicago, IL 60611 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1988Volume 109, Issue 3Page: 247-249 Issue Published: 1 August 1988 PDF DownloadLoading ...
THE TREATMENT OF ABSCESSES BY PUNCTURE AND DISINFECTION WITHOUT INCISION AND DRAINAGE.
Authors: De WITT STETTEN
Journal: JAMA (1907)

Stimulated by the results of Bier<sup>1</sup>and Klapp<sup>2</sup>with suction and hyperemia and of Lennander<sup>3</sup>with his carbolic-alcohol method, I have been led to attempt a conservative treatment of localized suppurations without elaborate apparatus on the one hand and without incision and drainage on the other. The plan I followed is not a new one. It is simply a modification of older methods with a newer application. What Scott Helm,<sup>4</sup>Hayden<sup>5</sup>and others tried with buboes I modified and extended to almost every form of acute external abscess. The object was to avoid mutilating scars and protracted convalescence from extensive incisions and long-continued drainage. Briefly stated, the method is as follows: After careful disinfection of the skin and under infiltration anesthesia of the most dependent portion of the abscess, the abscess is punctured with a large trocar or a pointed scalpel and the pus is
FRI0308 Gender Features of Vertebral Pain Syndrome Depending on Bone Mineral Density
Authors: V. Povoroznyuk, T. Orlyk
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> The aim is to study the frequency of vertebral pain syndrome in men and women of older age groups depending on the bone mineral density (BMD). <h3>Methods</h3> We have examined 1934 people aged 50-89 years, among them 1697 women and 237 men. The frequency of back pain syndrome was studied depending on the BMD (osteoporosis, osteopenia, and norm). BMD at all sites was measured by DXA using a Prodigy densitometer (GE). <h3>Results</h3> The frequency of pain syndrome among older age groups is significantly higher in women compared with men (88.3% (1499/1697) vs 84.8% (201/237), accordingly, p=0.01). In women of 50-89 years, with osteoporosis and no fractures in their anamnesis, pain syndrome in the thoracic and lumbar spine is significantly higher in comparison with women who have osteopenia (p=0.01) and normal BMD (p=0.02) and compared to men with a similar BMD state (osteoporosis; (91.8% (337/367) vs 76.2% (16/21), accordingly, p=0.01)). The frequency of pain syndrome in the thoracic and the lumbar spine in women is associated with BMD. The presence of osteoporosis increases the risk of pain syndrome in the thoracic spine (RR=1.27, 95% CI: 1.12-1 44, p=0.0001). In older women, the presence of low-energy fractures significantly impacts the increasing frequency of pain in the thoracic region regardless of the BMD state. <h3>Conclusions</h3> The frequency of pain among older age groups is significantly higher in women compared with men. In women of older age groups, the presence of low-energy fractures significantly increases the frequency of pain in the thoracic region, regardless of the state of BMD. In women 50-89 years old, with osteoporosis and no low-energy fractures, the frequency of pain in the thoracic and lumbar regions is significantly higher compared to women with osteopenia and normal BMD, as well as compared to men with a similar BMD state (osteoporosis). The frequency of pain in the thoracic and lumbar spine in women is associated with BMD. <h3>Disclosure of Interest</h3> None declared
Cigarette smoke inhalation patterns and bronchial reactivity.
Authors: D R Taylor, W D Reid, P D Pare, J A Fleetham
Journal: Thorax (1988)

The manner in which a cigarette is smoked varies considerably between individuals and may be an important determinant of the altered bronchial reactivity observed in cigarette smokers. Twenty smokers were examined to determine the relationship between cigarette smoke inhalation patterns and bronchial reactivity. Inhalation patterns were measured non-invasively with a respiratory inductive plethysmograph and these were related to the provocative concentration of histamine that caused a 20% fall in FEV1 (PC20) and to the cough threshold for inhaled citric acid. Histamine PC20 values were inversely correlated with depth and rate of inhalation. Cough threshold was inversely correlated with greater cigarette consumption and with depth of inhalation.
Clinical Evaluation of Perhexiline Maleate in Patients with Angina Pectoris
Authors: C. J. Burns-Cox, K. P. Chandrasekhar, H. Ikram, T. H. Peirce, J. Pilcher, C. D. M. Quinlan, J. R. Rees
Journal: BMJ (1971)

This paper reports a double-blind trial of a new antianginal drug, perhexiline. Fifty-five patients suffering from angina pectoris were studied for periods of 12 or 24 weeks in a cross-over comparison against a placebo in four centres in the United Kingdom and Ireland. Perhexiline was effective in most patients as judged by reducing the number of anginal attacks in 84% and the consumption of glyceryl trinitrate tablets in 64%. The major side effect, dizziness, noted in one-third of the patients, may be dose/body-weight related. Perhexiline is a valuable new agent for the treatment of patients with angina, especially those who do not respond to other antianginal agents.
Diagnostic Performance of Late Gadolinium Enhancement Analysis of Cardiac Magnetic Resonance Imaging in Monitoring Acute Cardiac Allograft Rejection
Authors: Evrim Şimşek, Sanem Nalbantgil, Naim Ceylan, Mehdi Zoghi, Deniz Nart, Mustafa Kurşun, Çağatay Engin, Tahir Yağdı, Mustafa Özbaran
Journal: Journal of the American College of Cardiology (2013)
Abstract 4315: Enrichment of xenotransplantable clonal cells in CD38high/CD138+ cells of multiple myeloma patients
Authors: Dongkyoon Kim, Irving L. Weissman
Journal: Cancer Research (2010)

Abstract Multiple myeloma is a plasma cell neoplasm characterized by frequent relapse following initial therapy, implying the presence of a therapy-resistant and tumor-initiating cell population. While tumor-initiating cells have been reported for human multiple myeloma, the data provide conflicting information regarding the surface immunophenotype of these cells. Here, we analyzed bone marrow myeloma and B-lineage cells of patients for fractionation, examined engraftment of myeloma cells in various mouse models, and finally investigated myeloma-initiating population by examining the repopulation of human myeloma cells in recipient mice. The clonality of repopulating cells was also determined by RT-PCR of immunoglobulin gene variable regions. First, the examination of immunophenotype of patients’ bone marrow cells allowed us to fractionate myeloma/plasma cell-enriching CD138+/CD38high plasmacytic cells and CD19+CD38low/− B lymphocytic cells in 82% (31/38) of human samples. Then, we transplanted patient bone marrow cells into RAG2−/−γc−/−, NOD/scid or NOD/scid/γc−/− mice with/without human fetal bone pieces and examined the engraftment of myeloma cells. While human bone-bearing mice engrafted myeloma/plasma cells of 10 out of 19 samples, none of 18 samples gave rise to the repopulation of clonal myeloma/plasma/B cells in human bone-free immunodeficient mice. Further analysis of fractionated cells demonstrated that CD38high/CD138+ cells led to production of clonal human antibodies (2/10 samples) and a repopulation of clonally-related CD19+CD38low or CD138+CD38+ B lineage cells (5/10 samples) in grafted human bone of recipient mice. However, CD19+CD38low/−CD138− cells did not engraft clonally-related cells in human bone-bearing mice (0/9 samples). The analysis of CD38high/CD138+ myeloma cells demonstrated that more than 70% of patients still have heterogeneous plasmacytic cells in the expressions of CD45, CD19 or CD27. Our results suggest that human bone marrow microenvironment may be required for the survival and the engraftment of primary myeloma cells into recipient mice and that CD38high/CD138+/− plasmacytic cells but not CD19+CD38low/− B cells enrich clonal myeloma cells engrafting into recipient mice which may be responsible for tumor-initiation of multiple myeloma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4315.
Redistribution of thallium at rest in patients with stable and unstable angina and the effect of coronary artery bypass surgery.
Authors: B C Berger, D D Watson, L R Burwell, I K Crosby, H A Wellons, C D Teates, G A Beller
Journal: Circulation (1979)

To determine the significance of redistribution (RD) of at rest in patients with coronary artery disease, 14 patients with unstable angina (UA) and 15 patients with stable angina (SA) referred for angiography underwent serial myocardial 201T1 imaging over 3 hours.No patients were imaged during pain. Antrior and left anterior oblique images were divided into six segments for analysis.The extent of coronary artery disease and the 201TI perfusion pattern were similar for UA and SA patients.In the 29 patients, 91 of 174 segments had decreased 2oiTl uptake on the 10-20-minute images. Atleast one initial defect was present in 26 of 29 patients, but only 14 of 29 had ECG evidence of infarction. Ondelayed 3-hour images, 69 of 91 segments with diminished initial uptake showed RD, while 22 defects persisted.Angiography demonstrated that 66 of 69 segments with RD had significant (> 70%) corresponding coronary artery stenoses.Wall motion analyses of 63 segments with RD revealed that 52 were normal or hypokinetic and 11 were akinetic or dyskinetic.Of 13 persistent defects, six were normal or hypokinetic and seven akinetic or dyskinetic (p > 0.02).In 22 patients who underwent coronary bypass surgery, 37 of 48 segments (77%) with decreased initial 201TI uptake and subsequent RD preoperatively reverted toward normal initial uptake postoperatively.In addition, 13 of 18 persistent defects preoperatively showed improved 201T1 uptake post- operatively.Thus, resting 201T1 defects may not represent myocardial scar.Patients with UA or SA may show RD of 201Tl at rest.Myocardial revascularization is usually associated with improvement in early 2oiTI uptake in segments with initial defects and RD preoperatively.PERFUSION DEFECTS on the resting thallium-201 (201Tl) scans 20 minutes after intravenous injection of the radionuclide in the absence of clinical or electrocardiographic evidence of acute ischemia are thought to represent areas of myocardial scar.1 Localized regions of diminished myocardial 201T1 up- take also occur in the presence of exercise-induced ischemia,2 3 during an episode of variant angina pec- toris,4 and with acute myocardial infarction.5 Results of a recent study" suggest that patients with unstable angina pectoris who are imaged in a pain-free period may have defects on resting scans that do not repre- sent myocardial infarction.Other studies have shown that serial myocardial imaging after a single dose of 201Tl administered during exercise can differenentiate between transient regional underperfusion or ischemia, which demonstrates redistribution of 201T1 over time, and regions of irreversibly injured myocar- dium, which did not show redistribution.
535 THYROID HORMONE RECEPTOR LIGANDS INDUCE REGRESSION OF RAT PRENEOPLASTIC LIVER LESIONS CAUSING THEIR REVERSION TO A DIFFERENTIATED PHENOTYPE
Authors: A. Perra, M.A. Kowalik, M. Pibiri, G.M. Ledda-Columbano, A. Columbano
Journal: Journal of Hepatology (2009)
Urinary tract infection in primary care
Authors: D. Mangin
Journal: BMJ (2010)

Cytochrome P450s (P450s) have been identified and analyzed in dogs and pigs, species that are often used in preclinical drug studies. Moreover, P450s are clinically important for drug therapy not only in humans, but also in species under veterinary care, including dogs and cats. In the present study, seven P450s homologous to human CYP2J2, namely, dog CYP2J2; cat CYP2J2; and pig CYP2J33, CYP2J35, CYP2J91, and CYP2J93, were newly identified and characterized, along with pig CYP2J34 previously identified. The cDNAs of these CYP2Js contain open reading frames of 502 amino acids, except for CYP2J35 (498 amino acids), and share high sequence identity (77%–80%) with human CYP2J2. Phylogenetic analysis revealed that dog and cat CYP2J2 were closely related, whereas pig CYP2Js formed a cluster. All seven <i>CYP2J</i> genes contain nine coding exons and are located in corresponding genomic regions, with the pig <i>CYP2J</i> genes forming a gene cluster. These CYP2J2 mRNAs were predominantly expressed in the small intestine with additional expression in the kidney and brain for dog CYP2J2 and pig CYP2J91 mRNAs, respectively. All seven CYP2Js metabolized human CYP2J2 substrates terfenadine, ebastine, and astemizole, indicating that they are functional enzymes. Dog CYP2J2 and pig CYP2J34 and CYP2J35 efficiently catalyzed ebastine primary hydroxylation and secondary carebastine formation at low substrate concentrations, just as human CYP2J2 does. Velocity<i>-</i>versus-substate plots exhibited sigmoidal relationships for dog CYP2J2, cat CYP2J2, and pig CYP2J33, indicating allosteric interactions. These results suggest that dog, cat, and pig CYP2Js have similar functional characteristics to human CYP2J2, with slight differences in ebastine and astemizole oxidations. <h3>SIGNIFICANCE STATEMENT</h3> Dog CYP2J2; cat CYP2J2; and pig CYP2J33, CYP2J34, CYP2J35, CYP2J91, and CYP2J93, homologous to human CYP2J2, were identified and characterized by sequence, phylogenetic, and genomic structure analyses. Intestinal expression patterns of CYP2J mRNAs were characteristic in dogs, cats, and pigs. Dog, cat, and pig CYP2Js likely play roles as drug-metabolizing enzymes in the small intestine, similar to human CYP2J2.
Immunotherapy with partially purified and standardized tree pollen extracts. IV. Results from long-term (6-year) follow-up
Authors: L. Jacobsen, B. Nüchel Petersen, J. Å. Wihl, H. Løwenstein, H. Ipsen
Journal: Allergy (1997)

The long-term effect of tree pollen extract immunotherapy was investigated 6 years after termination of the treatment. Subjective symptom evaluation of 36 patients 6 years after a 3-year period of immunotherapy showed that rhinitis and asthma symptoms remained at the improved level reached just after termination of the treatment. Some 86% of the rhinitis patients and 68% of the asthma patients maintained improvement. None of the rhinitis patients developed asthma in the study period. Skin prick tests reflected the outcome of the subjective symptom assessment. The skin sensitivity of the patients decreased significantly during immunotherapy, and the skin reactions 6 years after specific immunotherapy were still significantly lower than the pretreatment levels. Total IgE and birch-specific IgE levels were constant throughout the study period, and both the affinity and epitope specificity of the IgE antibodies of the patients were the same before, during, and 6 years after treatment. In conclusion, specific immunotherapy reduces symptoms in patients suffering from rhinitis and asthma, and the effect is maintained 6 years after termination of the treatment. Specific immunotherapy seems to prevent long-term development of asthma in rhinitis patients. IgE measurements do not reflect the overall status of the patients.