tbuckley/cabot-search huggingface dataset:
Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract
Authors: John D. Spencer, Andrew L. Schwaderer, Julianne D. DiRosario, Kirk M. McHugh, Glen McGillivary, Sheryl S. Justice, Ashley R. Carpenter, Peter B. Baker, Jürgen Harder, David S. Hains
Journal: Kidney International (2011)
The Continuing Challenge of Preterm Delivery
Authors: Melissa M. Adams
Journal: JAMA (1995)

Each year in the United States, approximately 31000 fetuses die before delivery and 22 000 newborns die during the first 27 days of life. Approximately 71% of fetal deaths and 74% of neonatal deaths occur among preterm infants (&lt;37 weeks' gestation). The rate of severe morbidity is several times higher for preterm survivors than infants born at term.<sup>1</sup>Because of the increased risks for death and morbidity associated with preterm delivery, its prevention is an important public health goal. Yet the rate of preterm delivery in the United States did not decrease during the 1980s. See also p 709. Wilcox and colleagues<sup>2</sup>conclude that an excess rate of preterm delivery in the United States, compared with Norway, accounts for excess perinatal mortality. This conclusion is supported by previous comparisons of the two countries in which a higher percentage of very low-birth-weight infants (&lt;1500 g), nearly all of whom
Eosinophil major basic protein in autologous serum and saline skin tests in chronic idiopathic urticaria
Authors: C.E.H. Grattan, R.K. Winkelmann, K.M. Leiferman
Journal: British Journal of Dermatology (1997)

Journal Article Eosinophil major basic protein in autologous serum and saline skin tests in chronic idiopathic urticaria Get access C.E.H. Grattan, C.E.H. Grattan Mancroft Dermatology Unit. West Norwich Hospital. Norwich NR2 3TU,. U.K. Search for other works by this author on: Oxford Academic Google Scholar R.K. Winkelmann, R.K. Winkelmann Department of Dermatology. Mayo Clinic. Rochester. MN 55905 and Scottsdale. AZ. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar K.M. Leiferman K.M. Leiferman Department of Dermatology. Mayo Clinic. Rochester. MN 55905 and Scottsdale. AZ. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 1, 1 January 1997, Pages 141–142, https://doi.org/10.1111/j.1365-2133.1997.tb08774.x Published: 01 January 1997
Increased Mean Platelet Volume May Reflect a Disturbance in the Autonomic Nervous System in Patients with Vasovagal Syncope
Authors: Hasan Kutsi Kabul, Murat Çelik, Emre Yalçınkaya, Uygar Çağdaş Yüksel, Yalçın Gökoğlan, Barış Buğan, Erkan Yıldırım, Erkan Kaya, Kubilay Karabacak, Turgay Çelik, Atila İyisoy
Journal: Journal of the American College of Cardiology (2013)
Measles Virus Suppresses Cell-mediated Immunity by Interfering with the Survival and Functions of Dendritic and T Cells
Authors: Isabelle Fugier-Vivier, Christine Servet-Delprat, Pierre Rivailler, Marie-Clotilde Rissoan, Yong-Jun Liu, Chantal Rabourdin-Combe
Journal: The Journal of Experimental Medicine (1997)

Secondary infections due to a marked immunosuppression have long been recognized as a major cause of the high morbidity and mortality rate associated with acute measles. The mechanisms underlying the inhibition of cell-mediated immunity are not clearly understood but dysfunctions of monocytes as antigen-presenting cells (APC) are implicated. In this report, we demonstrate that measles virus (MV) replicates weakly in the resting dendritic cells (DC) as in lipopolysaccharide-activated monocytes, but intensively in CD40-activated DC. The interaction of MV-infected DC with T cells not only induces syncytia formation where MV undergoes massive replication, but also leads to an impairment of DC and T cell function and cell death. CD40-activated DC decrease their capacity to produce interleukin (IL) 12, and T cells are unable to proliferate in response to MV-infected DC stimulation. A massive apoptosis of both DC and T cells is observed in the MV pulsed DC-T cell cocultures. This study suggests that DC represent a major target of MV. The enhanced MV replication during DC-T cell interaction, leading to an IL-12 production decrease and the deletion of DC and T cells, may be the essential mechanism of immunosuppression induced by MV.
End of static decade for coronary heart disease?
Authors: W C Smith, M. Kenicer, I. Crombie
Journal: BMJ (1984)

<h3>ABSTRACT</h3> Doctors increasingly rely on medical apps running on smart phones or tablet computers to support their work. However, these apps vary hugely in the quality of their data input screens, internal data processing, the methods used to handle sensitive patient data and how they communicate their output to the user. Inspired by Donabedian9s approach to assessing quality and the principles of good user interface design, the Royal College of Physicians’ Health Informatics Unit has developed and piloted an 18-item checklist to help clinicians assess the structure, functions and impact of medical apps. Use of this checklist should help clinicians to feel more confident about using medical apps themselves, about recommending them to their staff or prescribing them for patients.
Heterogeneous Immediate Effects of Partial Left Ventriculectomy on Cardiac Performance
Authors: John Gorcsan, Arthur M. Feldman, Robert L. Kormos, William A. Mandarino, Anthony J. Demetris, Randas J. V. Batista
Journal: Circulation (1998)

Background —Partial left ventriculectomy (PLV) is a novel surgical treatment for severe heart failure consisting of resection of a large wedge of myocardium to reduce wall stress and restore the normal mass-volume ratio. Although ejection fraction (EF) has been shown to improve after PLV, few other physiological data describing its immediate effects on left ventricular (LV) performance are available. Methods and Results —Eight patients, 58±5 years old, with severe clinical heart failure and EF of 12±3% were studied before and immediately after PLV. LV performance was assessed by the predominantly load-insensitive measures of pressure-area relations with high-fidelity pressure catheters and transesophageal automated echocardiographic measures of cross-sectional area as a surrogate for volume. LV end-diastolic volume decreased from 200±60 to 89±17 mL, EF increased from 12±3% to 41±8%, and right ventricular (RV) fractional area change increased from 24±12% to 37±16% (all P &lt;.05 versus before). Changes in pressure-area relations were variable: end-systolic elastance, 6.5±3.4 to 4.3±2.5 mm Hg/cm 2 and preload recruitable stroke work, 33±16 to 34±19 mm Hg ( P =NS versus before). End-diastolic stiffness increased from 0.13±0.06 to 0.19±0.07 mm Hg/cm 2 ( P &lt;.05 versus before). Improvement in LV performance was inversely correlated with semiquantitative histological assessment of myocardial fibrosis and positively correlated with nuclear enlargement and hyperchromasia, indicative of myocyte hypertrophy. No long-term follow-up data were available. Conclusions —PLV resulted in reductions in LV volumes, increases in EF and RV ejection, but increases in LV stiffness. Estimates of LV performance revealed variable results associated with the degree of myocardial fibrosis. Further study of these effects in relation to patient outcome is warranted.
Pneumocephalus as a Consequence of Barotrauma
Authors: Robert W. Goldmann
Journal: JAMA (1986)

PNEUMOCEPHALUS has been noted in a variety of medical and surgical conditions. The most common etiology is accidental and iatrogenic craniofacial trauma, with an incidence of 74.9% in an extensive review of 295 cases by Markham.1Other causes include neoplasm (osteomas,2epidermoid tumors,3and pituitary tumors), spinal anesthesia.4infection,5and neurilemoma.6No cases of pneumocephalus associated with rapid pressure change have been documented previously, although Markham did report a patient in whom symptoms were exacerbated during altitude changes of some 540 m (1,800 ft). We report the case of a previously healthy scuba diver who experienced pneumocephalus likely on the basis of air trapping and barotrauma.  Report of a Case  A 26-year-old healthy male scuba diving instructor was referred to the St Luke's Hospital (Milwaukee) Department of Hyperbaric Medicine by the Duke University Divers Alert Network. The patient had been engaged in fresh water
Psoriasis induced by interferon-α
Authors: J. FUNK, T. LANGELAND, E. SCHRUMPF, L.E. HANSSEN
Journal: British Journal of Dermatology (1991)

Journal Article Psoriasis induced by interferon‐α Get access J. FUNK, J. FUNK Departments of Dermatology, Rikshospitalet, Oslo, Norway Dr J. Funk, Department of Dermatology, Rikshospitalet, Pilestredet 32, N–0027 Oslo I, Norway. Search for other works by this author on: Oxford Academic Google Scholar T. LANGELAND, T. LANGELAND Departments of Dermatology, Rikshospitalet, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar E. SCHRUMPF, E. SCHRUMPF Departments of Rikshospitalet, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar L.E. HANSSEN L.E. HANSSEN Departments of Rikshospitalet, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 125, Issue 5, 1 November 1991, Pages 463–465, https://doi.org/10.1111/j.1365-2133.1991.tb14774.x Published: 01 November 1991
Abstract 620: Defects of homologous recombination repair in breast cancer: Identification of a novel RAD51-associated protein complex.
Authors: Jingsong Yuan, Junjie Chen
Journal: Cancer Research (2013)

Abstract Cells are continuously challenged by genotoxic agents from endogenous and exogenous sources. Severe DNA lesions, including DNA double-strand breaks (DSBs), have to be appropriately repaired for cell survival. Homologous recombination (HR) is particularly important for the repair of DSBs due to its ability to accurately restore genetic information. “Cancer is a disease of DNA repair”. The breast cancer susceptibility genes BRCA1 and BRCA2 encode DNA repair factors acting in the specific HR repair pathway. Germline mutations in many HR components, including BRCA1, BRCA2 and PALB2, are associated with cancers including breast cancer. Therefore, it is urgent to understand how HR repair is regulated in normal cells and how human cancers are defective in HR mediated repair. The RAD51 recombinase plays a central role in HR. To further study HR process, we performed tandem affinity purification of RAD51. Here, we report the identification of a new RAD51-binding protein FIGNL1 (fidgetin-like 1). Our experiments showed that FIGNL1 specifically interacts with RAD51 via its conserved RAD51-binding domain. Cells depleted of FIGNL1 show defective HR repair and hypersensitivity to Camptothecin and ionizing radiation, common regimens for cancer treatment. However, FIGNL1 is recruited to sites of DNA damage in a manner that is independent of BRCA2, RAD51 and RAD51 paralogs. Conversely, FIGNL1 depletion does not affect the loading of RAD51 onto single-strand DNA. Our experiments also uncovered KIAA0146 as a binding partner of FIGNL1 and established that KIAA0146 acts together with FIGNL1 in HR repair. More interestingly, our further study revealed that FIGNL1 and KIAA0146 protein level is dramatically reduced in some breast cancer cell lines. Altogether, our study reveals a sub-pathway of HR repair with newly identified components FIGNL1 and KIAA0146 and suggests their possible defects in breast cancer, therefore provides new potential directions for cancer diagnosis and therapy. Citation Format: Jingsong Yuan, Junjie Chen. Defects of homologous recombination repair in breast cancer: Identification of a novel RAD51-associated protein complex. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 620. doi:10.1158/1538-7445.AM2013-620
Anticancer drug targets: approaching angiogenesis
Authors: Eli Keshet, Shmuel A. Ben-Sasson
Journal: Journal of Clinical Investigation (1999)

For more than 50 years, a direct strategy dominated the field of cancer therapy. The selected target was the tumor cell itself; any cytotoxic drug that could kill tumor cells in vitro was by definition a candidate for in vivo chemotherapy. It soon became apparent, however, that normal cells could also be susceptible to the same spectrum of drugs. Moreover, because of the inherent genetic instability of neoplastic cells, exposure to chemotherapy eventually results in the selection of drug-resistant clones. The indirect strategy of antiangiogenic therapy provides an alternative that uses the evolving vasculature, which nourishes the growing tumor, as the prime target. With this approach, oncologists no longer need to restrict their attention to the individual cancer cell but may focus on its tissue context in general, and on angiogenesis, the process of blood-vessel formation, in particular. This conceptual framework, which has guided the search for new methods to identify novel anticancer drugs, is the subject of this Perspective.
Drug Fever From Tolmetin Administration
Authors: James Richard Brown
Journal: JAMA (1978)

<h3>To the Editor.—</h3> We are reporting an unusual adverse reaction to tolmetin sodium (Tolectin). Many agents and drugs have been reported to cause drug fever.<sup>1,2</sup>Possibly because of the limited clinical exposure tolmetin has received, reported adverse reactions have not included fever. The following case presents what appears to be drug fever attributable to tolmetin. <h3>Report of a Case. —</h3> The patient is a 56-year-old man who was admitted to Veterans Administration Hospital, Memphis, Tenn, in April 1977 for increasing cough and shortness of breath. The patient's condition was diagnosed as rheumatoid arthritis at the Memphis VA Hospital in 1974. In December 1976 drug therapy was changed from aspirin to tolmetin, and he obtained satisfactory relief of arthritic symptoms. Since then, he denies any episodes of fever, chills, night sweats, malaise, or skin eruptions. The physical examination results were consistent with pulmonary fibrotic changes and long-standing inflammatory joint disease.
Inducible Nitric Oxide Synthase Deficiency Does Not Affect the Susceptibility of Mice to Atherosclerosis but Increases Collagen Content in Lesions
Authors: Xi-Lin Niu, Xia Yang, Kiyotaka Hoshiai, Kazuo Tanaka, Sadaaki Sawamura, Yasuhiro Koga, Hiroe Nakazawa
Journal: Circulation (2001)

Although endothelial nitric oxide synthase (NOS) is antiatherogenic, the role of inducible NOS (iNOS) in the development of atherosclerosis is not established.We compared the susceptibility of iNOS knockout (iNOS(-/-)) and wild-type (iNOS(+/+)) mice to the development of atherosclerosis induced by feeding an atherogenic diet for 15 weeks. Plasma lipid level, atherosclerotic lesion size, and cellular density in the lesions were all similar in the 2 strains (lesion size: iNOS(+/+) 285+/-73x10(3) microm(2), iNOS(-/-) 293+/-82x10(3) microm(2), n=10). iNOS mRNA was detected in the lesions of iNOS(+/+) but not iNOS(-/-) mice through RT-PCR. Immunohistochemically, iNOS(+/+) mice showed iNOS staining in macrophages and medial smooth muscle cells in the lesions. Nitrotyrosine staining showed a similar distribution, whereas it was absent in iNOS(-/-) mice. There was no apparent difference in the intensity or distribution of vascular cell adhesion molecule-1 staining in the lesions of the 2 strains. However, the lesions of iNOS(+/+) mice showed a markedly decreased extracellular collagen content compared with those of iNOS(-/-) miceiNOS induction does not affect the development of atherosclerosis in mice fed an atherogenic diet, but the resulting lesions show decreased levels of extracellular collagen and may be more fragile.
Inguinal Ectopia of the Ovary, Tube and Uterus
Authors: Robert B. Tunney, Richard E. Hunter
Journal: New England Journal of Medicine (1950)

TRUE inguinal ectopia of the ovary is a rare condition. It is always congenital, involves the fallopian tube, may involve the uterus and may be associated with other genitourinary anomalies.1 The occurrence of a case of an inguinal ectopia of the ovary, tube and uterus associated with absence of the left kidney, an ectopic right kidney and congenital atresia of the vagina prompted this report. Mayer and Templeton2 reviewed the literature of the world and reported 138 cases of true inguinal ectopia of the ovary. Only 10 of these involved the uterus, 3 had associated maldevelopments of the renal system, . . .
Clinical Lecture on the Treatment of Rheumatic Fever, and of the Use of Alcohol in Serious Cases of this Disease
Authors: L. S. Beale
Journal: BMJ (1862)

spiration 00.TREATMENT.Alkalies.Three grains of opitum in twenty-four hours for eleven days.Strong mercutrial ointment and opium applied over the heart.Ten ounlces of brandy in twenty-four hours continuedfor eleven days.Convalescence three weeks after the dis- ease was at its worst stage.CASE II.A boy aged 16.Joint affection.Pericarditis with effusion.Slight pneumonia.Pulse 132; respir- ation, 72.TREATMENT as in Case I, but less opium was given, and only four ounces of brandy in twenty- four hours.Convalescence a fortnight after the dis- ease was at its worst.General remarks on the treatment pursuied.On the pro- priety of giving stimulanlts in cases of acute rheum- atism.GENTLEMEN,-I propose to-day to offer some re- marks on the treatment of rheumatic fever com- plicated with pericarditis.Of this disease, there have been recently several cases in the hospital;
Permanent Pacing of the Left Atrium for Treatment of WPW Tachycardia
Authors: T. A. PRESTON, MARVIN M. KIRSH
Journal: Circulation (1970)

A patient with WPW paroxysmal tachycardia was treated with a permanent artificial pacemaker, with the electrodes attached to the left atrium. The pacemaker is turned off at all times except when the patient activates it by holding a magnet over the implanted power unit. Random atrial pacing at a rate of 108/min has always terminated the tachycardia within 1 min, and usually within 10 sec. Left atrial pacing produced WPW type A QRS complexes, whereas regular sinus rhythm and right atrial pacing resulted in more normal QRS complexes. The distinct difference in the QRS complexes suggests preferential conduction through an abnormal pathway during left atrial pacing.
A Nonsurgical Test for the Diagnosis of Hirschsprung's Disease.
Authors: Marvin M. Schuster
Journal: Annals of Internal Medicine (1968)

s1 May 1968A Nonsurgical Test for the Diagnosis of Hirschsprung's Disease.Marvin M. Schuster, M.D., F.A.C.P., Fabio Tobon, M.D., James L. Talbert, M.D., Nigel Reid, M.R.C.P.Marvin M. Schuster, M.D., F.A.C.P.Search for more papers by this author, Fabio Tobon, M.D.Search for more papers by this author, James L. Talbert, M.D.Search for more papers by this author, Nigel Reid, M.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1149_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOther than deep rectal biopsy there is no good test that differentiates Hirschsprung's disease (aganglionic megacolon) from other forms of megacolon. In view of the involvement of the internal sphincter in the aganglionosis of this condition, rectosphincteric reflexes were studied in 10 patients with Hirschsprung's disease and compared with 34 normal subjects and with 31 patients with idiopathic megacolon to determine if a difference existed among these three groups. Reflexes were stimulated by transient distention of a rectal balloon and were recorded manometrically by a double balloon device from the internal anal sphincter (smooth muscle) and from the external anal... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1149-1149KeywordsAnal and rectal disordersAnusBiopsyMegacolonReflexesSmooth muscles Issue Published: 1 May 1968 PDF DownloadLoading ...
ON THE THREE COMMON INTESTINAL ENTAMOEBAE OF MAN, AND THEIR DIFFERENTIAL DIAGNOSIS
Authors: C. Dobell, M. W. Jepps
Journal: BMJ (1917)

THE COMMON INTESTINAL ENTAMOEflAE OF MAN.(M ^tTA.J oo it should be used for this purpose.There is barley and malt uLsed for the production of alcolhol, an inefficient form of food atthe best and a deadly poison in excess.According to tlle Food Controller thlere are one million quarters of brewer's mnalt in this country at tlle present time; it is not to be used for food, butt for tlle production of beer.The convictions for drunkenness in. the Metropolitan Police -District and tlle City for the first quarter of this year were 6,176.The Food Controller says that the food value of beer is not disputed, alnd the Government does not con- sider that it is necessary to save the millions of quarters of barley, malt, and othler foodstuffs wlicll are to be used in the manufacture of alcolholk There may be reasons of policy for allowing alcolhol to meni in the services or em- ployed in some essential occupations, but tllere is nolne for its widespread consumption.Oats can be used as a substitute for whleat, but there is clifficulty in obtainincg a ready and cleap supply; thle oats are beingy kept for the lhorses.A lhorse may consume 40 to 80 lb. of oats per week, and lhunters and racehorses receive the best.Huntingo, and racing lhave been and are allowved; only now is the Government taking steps to con- sider wlhetlher savings in this respect slhould be effected in the interests, of the food supply of tlhe people.Tllere are tllousanids of lhunters, racelhorses, riding lhorses, anid car- riage-horses, used only for pleasure in this counitry; the consumption of oats, niaize, beans, lhay, straw, and carrots by these animals must be enormotus.Witlh the exception of the lhay and straw, whNbich would be useful for cows, all these tons of food could be used by man himiiself; tlhe objection that thle horses are needed as a reserve for breed- ing and for the arnm lhas lno force, for all these animials could be liept at grass, aid' under these conditions -would liberate many mienli for essential worlk.TABLE II.-Perce t'aqfle Compositioni of Certain Cereals.-t Protein: Fat.Carbo-Fuel V'aluie Protein.Fat.hydrate.per lb.Calories.Wheat, flour 8.3 1.0 73.5 1615 Barley, pearled 6.6 1.0 76.1 1630 Maize, flour 5.8 1.2 76.3 1625 Oat, meal ... 13.4 6.6 65 2
Inhibition of lactation.
Authors: D. Tacchi
Journal: BMJ (1969)

support.We have been encouraged by the use of the long posterior flap below-knee amputation in conjunction with a limited myoplasty' in patients with femoral artery occlusion and absent popliteal pulsation.We find most cases are suitable for this pro- cedure rather than the occasional patient.We have performed this procedure on 17 patients and will shortly publish the pre- liminary results.We would make a plea that amputation is not left until the last moment in the man- agement of the patients, as a patient who has been allowed to lie in bed under heavy anal- gesics for his rest pain, or who comes to amputation at the end of a series of unsuc- cessful arterial operations, is less likely to be rehabilitated.To regard amputation as a positive part of the management of a patient with arterial disease rather than a defeat will do much to overcome this tendency.-Weare, etc.,
Allergens from mites: implications of cross‐reactivity between invertebrate antigens
Authors: R. C. Aalberse
Journal: Allergy (1998)

Group 1 and 2 allergens are probably the most important mite allergens. Some mite allergens, such as tropomyosin, are widely cross‐reactive. The prevalence of sensitization to invertebrates cannot be based solely on skin test or serologic data with the allergen extracts currently available. Purified (recombinant) allergens, selected for low cross‐reactivity, are urgently needed.