tbuckley/cabot-search huggingface dataset:
Oesophageal Atresia; A Critical Study of the Literature and Report on Sixteen Cases
Authors: Richard H. Adler
Journal: JAMA (1962)

This paperback monograph constitutes a review of congenital esophageal atresia and tracheoesophageal fistula. The author has analyzed various aspects of the subject, presenting views from the world literature in a well-organized and easy-to-read manner. Personal viewpoints are included in the analysis along with the case reports on 16 patients of the Onze Lieve Vrouwe Gasthius, Amsterdam. The historical aspects of esophageal atresia are presented in a chronological outline. The author devotes considerable space to a discussion of the pathogenesis of esophageal atresia in a section which covers the normal embryology of the esophagus and trachea, the various theories concerning intestinal as well as esophageal atresia, and the factors having a causal bearing on the genesis of this condition. Other areas covered in brief discussion include the pathologic physiology, the incidence, and the association with prematurity and other congenital anomalies, including maternal hydramnion. The main part of the monograph centers around
SPLENECTOMY FOR COMPLICATIONS OF CHRONIC GRANULOCYTIC LEUKÆMIA
Authors: A.S.D. Spiers, D.A.G. Galton, D. Catovsky, Eve Wiltshaw, A.G. Baikie, Juginder Kaur, J.M. Goldman, R.M. Lowenthal, N.A. Buskard
Journal: The Lancet (1975)
Letter: Allopurinol and iron
Authors: F. J. Ascione
Journal: JAMA (1975)

<h3>To the Editor.—</h3> As a psychiatrist, I must comment on the article entitled "Musical Hallucinations in Deafness" (231:620, 1975). An alternate theory to auditory hallucinations in deafness being "benign and nonpsychiatric" can certainly be that they are psychiatric as well as relatively benign; this explanation is probably most often the case.
Incidental Demonstration of Hepatic Amebic Abscess by Triple-Phase Bone Scintigraphy
Authors: GUO-LONG HUNG, CHARLES A. STEWART, KOUSHA ZARNEGAR
Journal: Clinical Nuclear Medicine (1995)

A 21-year-old male presented with a 2-month history of right shoulder pain and intermittent fever. Radiographs of the right shoulder were normal. A triple-phase bone scintigram showed no abnormalities in the shoulder, but the flow and blood pool images demonstrated an avascular area in the high, right upper quadrant which was ultimately found to be a hepatic amebic abscess. Although abdominal pain is the most common presenting symptom of hepatic amebic abscess, shoulder pain associated with an immobile diaphragm may also occur.
MIKULICZ'S DISEASE ASSOCIATED WITH ARRESTED MILIARY TUBERCULOSIS
Authors: T. W. Preston, B. L. Jeaffreson
Journal: BMJ (1925)

TMEIBALJRSNKramner, Tisdall, and Howlanid7 state that in nioimial blood thelproduct of the calciuiim an(d inorganiie phosphate values slhould be 40 or ovel, wlhile in rickets it is reduced below this value.Gyiirgy9 iises the quiotienit of tlhe or'ganlic plhosphate into the calciumii values, an(d states that in normial cases this figur-e should be 1.95, in rickets 3.5, anid iii tetany 1.4.Five cases in Group 3 of the presenit iniv'estiga- tioni show a lowered product, but a lowered quotient also, due to the lowering of the calciuml vatlue, wlile the hllosphate value reMained normal.The quotient (witlh one exception, where it is 1.32), thoulgh low-ered, is imever as low as in cases of tetany, and the significanice of tlis clhanige is not evident.CONcLU.SIONS.
Epidemiological study of abdominal tuberculosis among Indian migrants and the indigenous population of Leicester, 1972-1989.
Authors: C S Probert, V Jayanthi, A C Wicks, D L Carr-Locke, P Garner, J F Mayberry
Journal: Gut (1992)

A retrospective, epidemiological study of abdominal tuberculosis in the city of Leicester from 1972 to 1989 is reported. Potential cases were identified from hospital medical records and endoscopy lists, in addition to the county notification register. The city population of 280,000 included over 75,000 South Asians. There were 146 cases among South Asians and six in Europeans, four of whom were British. The standardised incidence of abdominal tuberculosis in South Asians decreased significantly from 22.3 cases/10(5)/year during the 1970s to 9.2 cases/10(5)/year in the 1980s (chi 2 = 42, p &lt; 0.001). The incidence during the 1980s was 10.7/10(5)/year in Hindus, 8.7/10(5)/year in Sikhs, and 4.6/10(5)/year in Muslims. The relative risk to Hindus was 2.3 fold greater, and for Sikhs 1.9 fold greater, than that for Muslims, a finding similar to that in pulmonary tuberculosis. The standardised incidence in Europeans was 0.2/10(5)/year and they had significantly less abdominal tuberculosis than South Asians (Z = 8.6, p &lt; 0.001 and relative risk = 46). The standardised mortality ratio was significantly increased in Europeans (standardised mortality ratio = 755, 95% confidence interval 90-2730, chi 2 = 11.4, p &lt; 0.001), but not in South Asians (standardised mortality ratio = 68, 95% confidence interval 20-160). Resection rates were similar between the two ethnic groups. Abdominal tuberculosis still occurs among migrants, and clinicians should remain alert to this in South Asians.
Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10
Authors: D Benedetti, R Bomben, M Dal-Bo, D Marconi, A Zucchetto, M Degan, F Forconi, G Del-Poeta, G Gaidano, V Gattei
Journal: Leukemia (2007)
(6) Muckle Wells syndrome (urticaria, amyloidosis and deafness)
Authors: R.H. Champion
Journal: British Journal of Dermatology (1989)

Journal Article (6) Muckle Wells syndrome (urticaria, amyloidosis and deafness) Get access R.H. Champion R.H. Champion Addenbrooke's Hospital, Cambridge Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue s34, 1 July 1989, Page 75, https://doi.org/10.1111/j.1365-2133.1989.tb05982.x Published: 01 July 1989
UK doctors may face revalidation
Authors: L. Beecham
Journal: BMJ (1998)

The General Medical Council is opening discussions on whether consultants and general practitioners should be revalidated, perhaps at five year intervals, to confirm and show their qualities tothe outside world.

The proposals come in the wake of the GMC's decisions on the Bristol case, in which three doctors were found guilty of serious professional misconduct (27 June, p 1924) and the continuation of professional self …
Cardiac manifestations of malignant hyperthermia susceptibility.
Authors: V F Huckell, H M Staniloff, B A Britt, M B Waxman, J E Morch
Journal: Circulation (1978)

Malignant hyperthermia is a disease resulting from defective cellular membranes, usually presenting as drug-induced pyrexic crises. We describe four patients with life threatening ventricular arrhythmias or chest pain in the absence of pyrexic crises. Three presented with life threatening arrhythmias and the fourth with severe atypical chest pain. Two patients had a family history of multiple sudden deaths. Resting CKs were elevated in three patients while CK-MB was elevated in one. Resting ECGs were abnormal in three. Three patients had recurrent ventricular tachycardia, two had recurrent ventricular fibrillation and multiple cardiac arrests. Cardiac catheterization showed abnormal left ventricular wall motion in two and minimal mitral valve prolapse in one while all had normal coronary arteries. Thallium-201 myocardial imaging demonstrated large perfusion defects in the patient with electrocardiographic Q waves and normal coronary arteries. Myocardial involvement has been demonstrated by clinical, electrocardiographic, hemodynamic, angiographic and myocardial imaging abnormalities. Malignant arrhythmias occurred in these patients in the absence of pyrexic crises or drug admininstration. Abnormal calcium release in the myocardium, as documented in skeletal muscle membranes, may be a unifying concept for the various manifestations described.
Rupture of the Spleen in Amyloidosis
Authors: Howard Wilson
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Amyloidosis includes a group of disorders with a variety of clinical features that generally are a result of the deposition of a proteinaceous, finely fibrillar, eosinophilic, hyaline extracellular substance.<sup>1</sup>The diagnosis of amyloidosis is established by histological examination and special stains of tissue obtained by biopsy or, more commonly, at autopsy. The clinical manifestations of the disease are usually subtle and nonspecific. The following case of amyloidosis is noteworthy because the patient's initial condition was that of an acute abdomen secondary to rupture of the spleen. <h3>Report of a Case.—</h3> A 49-year-old man was brought to the Ben Taub General Hospital emergency room with a complaint of left upper quadrant abdominal pain that had become progressively worse during several days. He gave no history of trauma or abdominal injury in the previous week. He denied past specific chronic or acute illnesses. However, he did state that
DIMENSIONAL, OSMOTIC, AND CHEMICAL CHANGES OF ERYTHROCYTES IN STORED BLOOD. IV. CELLS SEPARATED FROM PLASMA 1
Authors: S. Rapoport, Mary Wing
Journal: Journal of Clinical Investigation (1947)

The possibility of utilizing erythrocytes remain- ing after the removal of plasma has been of in- creasing interest in the last years with the expand- ing use of plasma and its derivatives and with better understanding of the clinical use of red cells.Although several reports of the large-scale use of resuspended cells are available* (1 to 9), only scant information exists on in vitro changes tak- ing place in separated red cells during storage in the packed state or in resuspension.The present study, part of an investigation dealing with in vitro changes of stored blood, is concerned with dimensional, osmotic, and chemical changes of separated cells .In view of the fact that the American Red Cross during the war collected blood in simple citrate solution as well as in ACD solution, depending on whether the blood was to be used as such or for the preparation of plasma, both types of cells, those derived from bloods collected in simple citrate solution and.those from bloods collected in ACD solution, were studied.The purposes of the study may be defined as follows: (1) to establish the validity of in vitro testing of separated red cells and (2) to delimit, if possible, the optimum con- ditions of storage and the best type of resuspension fluid for separated cells.In most instances the' report will be limited to a presentation of changes of 4 indices of blood preservation: (1) hemolysis in 0.6 per cent NaCl solution, (2) changes in cellu- lar thickness, (3) adenosine triphosphate content, and (4) glycolyzing power of erythrocytes.Com- plete measurements of dimensional changes, including diameter, surface and volume; of the os- motic behavior; and of the phosphorus and cation distributions were performed as described in the first paper of this series (10), but are omitted here
Comparison of total body surface map depolarization patterns of left bundle branch block and normal axis with left bundle branch block and left-axis deviation.
Authors: G S Sohi, N C Flowers, L G Horan, M R Sridharan, J C Johnson
Journal: Circulation (1983)

Total body surface maps from 15 subjects with left bundle branch block and normal axis (LBBB-NA) and 10 subjects with left bundle branch block and left axis (LBBB-LA) were analyzed and compared with maps from normal subjects. In 19 of the 25 subjects with LBBB, the timing of early upper sternal positivity was similar to that of normal subjects, indicative of timely but oppositely directed septal activation. The right ventricular breakthrough was normally located in all, but was earlier after the onset of QRS than expected in some. The initial portion of the positivity produced by left ventricular activation was located in the upper anterior chest in both LBBB-NA and LBBB-LA, but its onset was generally delayed compared with that in normal subjects, presumably because of the time taken by the right-to-left septal activation. Also, the total duration of this positivity was longer than in normal subjects and extended considerably beyond 90 msec, indicating prolonged activation of the anterior free wall of the left ventricle. In LBBB-NA, this upper anterior positivity remained anterior throughout depolarization, but in LBBB-LA it moved toward the left shoulder and the left upper back, presumably due to the posterior orientation of the terminal portion of depolarization. This terminal orientation in patients with LBBB-LA was thought to be due to the additional delay in the activation of the anterobasal portion of the left ventricle caused by selective involvement of the left anterior fascicle.
A History of Medicine in South Carolina 1670-1825
Authors: Lester S. King
Journal: JAMA (1964)

In medicine the careful study of a single organ can give surprising information about the whole body. The eye, the skin, the hand, can mirror systemic changes and, when studied by a knowing physician, tell a remarkably detailed story. The same situation obtains in the field of history. Careful study of one geographical area can provide data which not only have local interest but which reflect trends and principles of broad national import. Dr. Waring, through his intensive study of South Carolina medicine, has thrown into sharp relief the local problems and their solutions, and, by his careful attention to one particular area, has also illuminated in a general sense the problems of early American medicine. He has made a systematic approach, carefully investigated the rich primary sources, reviewed and sifted the secondary sources, and synthesized the results in a well-ordered narrative. The author has devoted many years to historical
NHS is doing well, but financial squeeze poses serious risks, King's Fund says
Authors: N. Hawkes
Journal: BMJ (2012)

Halfway through the term of the coalition government the NHS continues to perform well, a report from the healthcare think tank the King’s Fund has found.1

Substantial productivity gains have been made (£4.3bn (€5.3bn; $6.9bn) in 2010-11 and £5.8bn in 2011-12), without waiting lists growing longer or patients’ experience of care getting worse.

The incidence of healthcare acquired infections has continued to fall, with that of meticillin resistant Staphylococcus aureus falling by 42% and Clostridium difficile by 55% between May 2010, when the government took office, and September 2012. 

Good progress has been made on the commitment to eliminate mixed sex …
Duplex Scanning of Renal Arteries for Stenosis
Authors: Richard G. Appel
Journal: Annals of Internal Medicine (1996)

Letters1 February 1996Duplex Scanning of Renal Arteries for StenosisRichard G. Appel, MD, Anthony J. Bleyer, MD, and Kimberley J. Hansen, MDRichard G. Appel, MDBowman Gray School of Medicine; Winston-Salem, NC 27157Search for more papers by this author, Anthony J. Bleyer, MDBowman Gray School of Medicine; Winston-Salem, NC 27157Search for more papers by this author, and Kimberley J. Hansen, MDBowman Gray School of Medicine; Winston-Salem, NC 27157Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-3-199602010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent report, Olin and colleagues ([1]) state that a renal artery end diastolic velocity of 150 cm/sec or greater is an important criterion for diagnosing critical renal artery stenosis. This appears to be correct; however, for an end diastolic velocity of 150 cm/sec to have a high clinical utility, values less than 150 cm/sec should be helpful in identifying arteries that lack critical stenosis. Figure 3 of Olin and colleagues' report shows that this is clearly not the case ([1]). Several investigators have shown that end diastolic velocity correlates inversely with serum creatinine levels ([2]). ...References1. Olin JW, Piedmonte MR, Young JR, De Anna S, Grubb M, Childs MB. The utility of duplex ultrasound scanning of the renal arteries for diagnosing significant renal artery stenosis. Ann Intern Med. 1995; 122:833-8. Google Scholar2. Hansen KJ, Tribble RW, Reavis SW, Canzanello VJ, Craven TE, Plonk GW Jr, et al. Renal duplex sonography: evaluation of clinical utility. J Vasc Surg. 1990; 12:227-36. Google Scholar3. Appel RG, Bleyer AJ, Reavis S, Hansen KJ. Renovascular disease in older patients beginning renal replacement therapy. Kidney Int. (In press). Google Scholar Author, Article, and Disclosure InformationAffiliations: Bowman Gray School of Medicine; Winston-Salem, NC 27157 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRenal Artery Duplex Ultrasonography 1 February 1996Volume 124, Issue 3Page: 370-371KeywordsArteriesBlood pressureCreatinineRenal arteriesRenal diseasesRevascularizationStenosis Issue Published: 1 February 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Conscious Analgesia and Amnesia for Cardioversion
Authors: Charles E. Reier
Journal: JAMA (1969)

Conscious analgesia (stage I, plane 3) produced by the inhalation of methoxyflurane was used in 20 consecutive patients who underwent 22 elective direct-current countershock procedures for supraventricular arrhythmias. After the drug had been administered in concentrations adequate to produce signs of perseveration, loss of memory, delayed response to verbal commands, and inability to focus eyes, the direct-current countershock was delivered. Although the patients responded to verbal commands just prior to the procedure, postoperative interviews revealed complete amnesia. No significant changes in heart rate, blood pressure, or ventilation were noted. Following the procedure, emergence to an alert, oriented state occurred within two to five minutes. The technique provided both analgesia and amnesia—but without general anesthesia.
HISTOPATHOLOGIC EVIDENCE OF ADVENTITIAL CUTS PREDICTS RESTENOSIS AFTER DIRECTIONAL ATHERECTOMY OF LOWER EXTREMITY PERIPHERAL ARTERIAL DISEASE: RESULTS FROM A RANDOMIZED, OPEN LABEL, INVESTIGATOR-INITIATED TRIAL COMPARING INTRAVASCULAR ULTRASOUND-GUIDED ATHERECTOMY TO ANGIOGRAPHY GUIDED ATHERECTOMY IN PERIPHERAL VASCULAR INTERVENTIONS FOR TASC&amp;apos;S A, B LESIONS (UTOPIA) PILOT STUDY
Authors: Prakash Krishnan, Usman Baber, K-Raman Purushothaman, Meerarani Purushothaman, Jose Wiley, Arthur Tarricone, Roxana Mehran, Jason Kovacic, Michael Kim, Pedro Moreno, Annapoorna Kini, George Dangas, Samin Sharma
Journal: Journal of the American College of Cardiology (2012)
N-acetyl cysteine as an osteogenesis-enhancing molecule for bone regeneration
Authors: Masahiro Yamada, Naoki Tsukimura, Takayuki Ikeda, Yoshihiko Sugita, Wael Att, Norinaga Kojima, Katsutoshi Kubo, Takeshi Ueno, Kaoru Sakurai, Takahiro Ogawa
Journal: Biomaterials (2013)
Point-of-care multiorgan ultrasonography for the evaluation of undifferentiated hypotension in the emergency department
Authors: G. Volpicelli, A. Lamorte, M. Tullio, L. Cardinale, M. Giraudo, V. Stefanone, E. Boero, P. Nazerian, R. Pozzi, M. F. Frascisco
Journal: Intensive Care Medicine (2013)
Clinical findings and immunological abnormalities in Yu-Cheng patients.
Authors: Y C Lü, Y C Wu
Journal: Environmental Health Perspectives (1985)

An outbreak of poisoning caused by ingestion of rice bran oil which was accidentally contaminated with polychlorinated biphenyls (PCBs) broke out in Taiwan in February 1979. Diagnosis, management, and follow-up of the patients were performed at special clinics, and subjective symptoms and cutaneous changes such as peculiar acneform eruptions and pigmentation were recorded. The patients were divided into six age groups of both essex, and the body surface of the patients was divided into 12 sections according to the nature of skin. The prevalence of each type of cutaneous change was proved statistically by the chi-square test. The examination of the immune system function in the patients at 1 year revealed: decreased concentration of IgM and IgA but not of IgG; decreased percentage of total T-cells, active T-cells, and helper T-cells, normal percentage of B-cells and suppressor T-cells; suppression of delayed type response to recalling antigens; enhancement of lymphocyte spontaneous proliferation; and enhancement of lymphocyte proliferation with PHA, PWM, and PPD stimulation but not ConA. Follow-up studies 3 years later showed decreased blood PCB levels; some improvement of subjective symptoms and cutaneous changes; recovery of skin testing response to PPD; normal percentage of total T-cells and increased percentage of suppressor T-cells; and enhancement of lymphocyte proliferation spontaneously or under the stimulation of various mitogens.
Selective Concentration of Anticancer Drugs in the Liver
Authors: Louis M. Rousselot
Journal: JAMA (1965)

Selective concentration of drugs infused in the liver via the hepatic artery was produced by the introduction of a double balloon catheter with internal bypass into the vena cava in a dog and inflating the balloons at the level of hepatic veins for ten minutes. Control studies in 40 dogs showed that dogs could tolerate ten minutes of total hepatic-outflow block. In 20 dogs, 0.4 mg mechlorethamine hydrochloride was administered via the hepatic artery with temporary outflow block; all of the dogs survived. Similar results were found with fluorouracil. Radiological and biochemical studies showed drug stasis in the liver during block. This technique may become applicable to the use of short acting alkylating agents, antibiotics, or antimetabolites in hepatic-artery infusion chemotherapy. Pilot studies applying outflow block during hepatic-artery infusion have begun in humans.
Continuous opportunistic and systematic screening for hypertension with computer help: analysis of non-responders.
Authors: F Difford, J P Telling, K R Davies, J E Fornear, C A Reading
Journal: BMJ (1987)

For two years an office computer was used to identify patients to prompt for opportunistic screening and call for systematic screening. After the two years 92% of patients on the list had had blood pressure readings recorded within the previous five years, of which 34% resulted from special prompts and 22% from screening letters. Those who failed to respond to letters were sent questionnaires, and their records were compared with those of screened patients. With the help of a microcomputer it is practicable to sustain a continuous screening rate of between 90% and 95%.
ETIOLOGY OF SILICOSIS
Authors: A. J. LANZA
Journal: JAMA (1933)

The Committee on Pneumoconiosis and the Committee on Standards of the American Public Health Association, at a joint meeting in November, 1932, adopted the following definition of silicosis: Silicosis is a disease due to breathing air containing silica (SiO<sub>2</sub>) characterized anatomically by generalized fibrotic changes and the development of miliary nodulation in both lungs, and clinically by shortness of breath, decreased chest expansion, lessened capacity for work, absence of fever, increased susceptibility to tuberculosis (some or all of which symptoms may be present) and by characteristic x-ray findings. The disease is divided arbitrarily into first, second and third stages for convenience of description and possible compensation purposes. I wish to make clear that in this discussion we are concerned with true silicosis and not with other forms of pneumonoconiosis due to the inhalation of dusts containing combined silica in the form of silicates or of organic dusts. Numerous dusts
Therapeutic uses for neural grafts: Progress slowed but not abandoned
Authors: Ronald H. Baisden
Journal: Behavioral and Brain Sciences (1995)

Abstract In spite of Stein and Glasier's justifiable conclusion that initial optimism concerning the immediate clinical applicability of neural transplantation was premature, there exists much experimental evidence to support the potential for incorporating this procedure into a therapeutic arsenal in the future. To realize this potential will require continued evolution of our knowledge at multiple levels of the clinical and basic neurosciences.