tbuckley/cabot-search huggingface dataset:
Abstract 1038: Regulation of cyclin A by FoxO3a drives proliferation in anaplastic thyroid carcinoma
Authors: Laura Marlow, Christina von Roemeling, Yilin Zhang, Simon Cooper, Stephen Rohl, Han Tun, Peter Storz, Robert Smallridge, John A. Copland
Journal: Cancer Research (2011)

Abstract The Forkhead transcription factor, FoxO3a, is a known suppressor of primary tumor growth and is negatively regulated by growth factors via phosphorylation and mislocalization from the nucleus to the cytoplasm. Here we show for the first time that FoxO3a is nuclear in anaplastic thyroid carcinoma (ATC) and it transcriptionally upregulates cyclin A thereby promoting tumor growth in human ATC cells. Silencing FoxO3a in ATC cell lines leads to down-regulation of cyclin A mRNA and protein while over-expression of FoxO3a leads to upregulation of cyclin A protein. Transient co-transfection of cyclin A promoter linked to luciferase with FoxO3a leads to enhanced luciferase activity, which can be ablated when mutating the FoxO3a site on the cyclin A promoter. This combined data implicates an entirely novel function for FoxO3a in modulating cancer progression by promoting cell cycle progression and tumor growth. ATC is a poorly differentiated carcinoma with average survival upon diagnosis of 3–4 months with 99% lethality, notably the most aggressive and deadliest cancers known. This data also suggest that any therapies under development to inactivate FOXO3a may be effective at blocking tumor expansion. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1038. doi:10.1158/1538-7445.AM2011-1038
Efficacy of activated recombinant factor VII (RFVIIA; Novoseven®) in cirrhotic patients with upper gastrointestinal bleeding: A randomised placebo-controlled double-blind multicenter trial
Authors: D. Thabut, R. de Franchis, F. Bendtsen, G. D'Amico, A. Albillos, J.G. Abraldes, S. Fabricius, J. Bosch
Journal: Journal of Hepatology (2003)
Differences in Right Ventricular Remodeling Secondary to Pressure Overload in Patients with Pulmonary Hypertension
Authors: Jose Gomez-Arroyo, Luis E. Santos-Martinez, Alberto Aranda, Tomas Pulido, Miguel Beltran, Luis Muñoz-Castellanos, Erick Dominguez-Cano, Chiara Sonnino, Norbert F. Voelkel, Julio Sandoval
Journal: American Journal of Respiratory and Critical Care Medicine (2014)
Characterization of Depigmented-Polymerized Pollen Extracts for Allergen Immunotherapy: Presence of Relevant Allergens and Molecular Size Consistency
Authors: Jerónimo Carnés, María Morales, Raquel Moya, M. Angeles López Matas, Tamara Aranda, Beatriz Rojas, Beatriz Martinez, José Ramón Leonor, Victor M. Iraola, Mª Teresa Gallego
Journal: Journal of Allergy and Clinical Immunology (2015)
Antimicrobial Prophylaxis of Recurrent Urinary Tract Infections
Authors: WALTER E. STAMM
Journal: Annals of Internal Medicine (1980)

To study once-daily antimicrobial prophylaxis of urinary tract infections, we gave trimethoprim-sulfamethoxazole (40 mg/200 mg), trimethoprim (100 mg), nitrofurantoin macrocrystals (100 mg); or placebo to 60 women for 6 months. During prophylaxis, infections per patient year were comparable in the groups receiving trimethoprim (0.0), nitrofurantoin (0.14), or trimethoprim-sulfamethoxazole (0.15) and occurred less frequently than in patients receiving placebo (2.8; P < 0.001, placebo versus each drug regimen). The effectiveness of prophylaxis was limited to the 6 months that antimicrobials were given, and infections were more likely to develop after prophylaxis in women who had three or more infections in the year before prophylaxis (P < 0.005). Further, women whose preprophylaxis infection was positive for antibody-coated bacteria were more likely to have same-strain relapse when infections recurred (P = 0.001). Emergence of trimethoprim-resistant Escherichia coli was rare, but non-E. coli infections occurred more often after prophylaxis (P < 0.05). Prophylaxis with these drugs is effective, well tolerated, and did not produce emergence of resistant E. coli but may predispose to non-E. coli urinary tract infections after its discontinuation.
Oslerian Anniversary: Incorporating the Fitzpatrick Lecture for 1975
Authors: Charles C. Roland
Journal: JAMA (1977)

The title refers not to a holy day, but rather to the 300th meeting of the Osler Club of London. Six essayists undertake the customary memorial tributes, and the 1975 Fitzpatrick Lecture to the Royal College of Physicians is included. This arrangement is not so arbitrary as it may at first seem, because the Osler Club on this occasion was meeting jointly with the Royal College, and the lecturer, W. C. Gibson of Vancouver, is a noted Oslerian who spoke on three of Sir William's fellow Canadians—Fred Banting, Norman Bethune, and Brock Chisholm. Gibson's address (rather, the shortened version reproduced here) is too terse to be fully satisfying, yet he contrives to induce a sympathetic interest in his subjects, each of whom was a bit of an iconoclast in his own way. Indeed, Bethune and Chisholm could fairly be called eccentric. Especially enlightening is the current growth of Canadian interest
1272 Serum amyloid a activates proinflammatory signaling pathways and enhances chemokine secretion in activated human hepatic stellate cells
Authors: R SCHWABE, R BATALLER, D BRENNER, H JIJON
Journal: Hepatology (2003)

Lyme neuroborreliosis, caused by the spirochete Borrelia burgdorferi, often manifests by causing neurocognitive deficits. As a possible mechanism for Lyme neuroborreliosis, we hypothesized that B. burgdorferi induces the production of inflammatory mediators in the central nervous system with concomitant neuronal and/or glial apoptosis. To test our hypothesis, we constructed an ex vivo model that consisted of freshly collected slices from brain cortex of a rhesus macaque and allowed live B. burgdorferi to penetrate the tissue. Numerous transcripts of genes that regulate inflammation as well as oligodendrocyte and neuronal apoptosis were significantly altered as assessed by DNA microarray analysis. Transcription level increases of 7.43-fold (P = 0.005) for the cytokine tumor necrosis factor-α and 2.31-fold (P = 0.016) for the chemokine interleukin (IL)-8 were also detected by real-time-polymerase chain reaction array analysis. The immune mediators IL-6, IL-8, IL-1β, COX-2, and CXCL13 were visualized in glial cells in situ by immunofluorescence staining and confocal microscopy. Concomitantly, significant proportions of both oligodendrocytes and neurons undergoing apoptosis were present in spirochete-stimulated tissues. IL-6 production by astrocytes in addition to oligodendrocyte apoptosis were also detected, albeit at lower levels, in rhesus macaques that had received in vivo intraparenchymal stereotaxic inoculations of live B. burgdorferi. These results provide proof of concept for our hypothesis that B. burgdorferi produces inflammatory mediators in the central nervous system, accompanied by glial and neuronal apoptosis.
Pilot Prospective Evaluation of 99mTc-MDP Scintigraphy, 18F NaF PET/CT, 18F FDG PET/CT and Whole-Body MRI for Detection of Skeletal Metastases
Authors: Andrei Iagaru, Phillip Young, Erik Mittra, David W. Dick, Robert Herfkens, Sanjiv Sam Gambhir
Journal: Clinical Nuclear Medicine (2013)

Objective The aim of this study was to compare 99mTc-MDP bone scanning, 18F NaF PET/CT, 18F FDG PET/CT, and whole-body MRI (WBMRI) for detection of known osseous metastases. Patients and Methods This prospective pilot trial (September 2007-April 2009) enrolled 10 participants (5 men, 5 women, 47–81 years old) diagnosed with cancer and known osseous metastases. 18F NaF PET/CT, 18F FDG PET/CT, and WBMRI were performed within 1 month for each participant. Results The image quality and evaluation of extent of disease were superior by 18F NaF PET/CT compared to 99mTc-MDP scintigraphy in all patients with skeletal lesions and compared to 18F FDG PET/CT in 3 of the patients with skeletal metastases. 18F NaF PET/CT showed osseous metastases where 18F FDG PET/CT was negative in another 3 participants. Extraskeletal metastases were identified by 18F FDG PET/CT in 6 participants. WBMRI with the combination of iterative decomposition of water and fat with echo asymmetry and least-squares estimation, short tau inversion recovery, and diffusion-weighted imaging pulse sequences showed fewer lesions than 18F NaF PET/CT in 5 patients, same number of lesions in 2 patients, and more lesions in 1 patient. WBMRI showed fewer lesions than 18F FDG in 3 patients and same lesions in 6 patients. Conclusions Our pilot phase prospective trial demonstrated superior image quality and evaluation of skeletal disease extent with 18F NaF PET/CT compared to 99mTc-MDP scintigraphy and 18F FDG PET/CT, as well as the feasibility of multisequence WBMRI. In addition, 18F FDG PET/CT provided valuable soft-tissue information that can change disease management. Further evaluation of these findings using the recently introduced PET/MRI scanners is warranted.
Alterations in polyunsaturated fatty acid composition of cardiac membrane phospholipids and 1 adrenoceptor mediated phosphatidylinositol turnover
Authors: J. T A Meij, A. Bordoni, D. H W Dekkers, C. Guarnieri, J. M J Lamers
Journal: Cardiovascular Research (1990)

Journal Article Alterations in polyunsaturated fatty acid composition of cardiac membrane phospholipids and α1 adrenoceptor mediated phosphatidylinositol turnover Get access Johanna T A Meij, Johanna T A Meij Correspondence to: Dr Lamers Search for other works by this author on: Oxford Academic PubMed Google Scholar Alessandra Bordoni, Alessandra Bordoni Search for other works by this author on: Oxford Academic PubMed Google Scholar Dirk H W Dekkers, Dirk H W Dekkers Search for other works by this author on: Oxford Academic PubMed Google Scholar Carlo Guarnieri, Carlo Guarnieri Search for other works by this author on: Oxford Academic PubMed Google Scholar Jos M J Lamers Jos M J Lamers Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 2, February 1990, Pages 94–101, https://doi.org/10.1093/cvr/24.2.94 Published: 01 February 1990 Article history Received: 23 March 1989 Accepted: 21 September 1989 Published: 01 February 1990
Extent of measles hepatitis in various ages
Authors: Hanna Shalev-Zimels, Zvi Weizman, Chaim Lotan, Dov Gavish, Zvi Ackerman, Abraham Morag
Journal: Hepatology (1988)

To assess extent of hepatic involvement in measles, we evaluated prospectively 144 patients (ages 0.2 to 43 years) during an outbreak. Liver function parameters (AST, ALT, serum gamma-glutamyl transpeptidase and bilirubin) were determined on presentation and at 2 and 4 weeks. The study comprised 52 pediatric (less than or equal to 14 years) and 92 adult patients. Liver dysfunction was evident quite often (56 to 66%) in adult patients. However, in the pediatric age group, these abnormalities were less frequent and less extensive. Moreover, a significant correlation was noted between age and each of the following parameters: AST (r = 0.61), ALT (r = 0.56) and serum gamma-glutamyl transpeptidase (r = 0.39). In all subjects all parameters normalized after 2 to 4 weeks. The data presented suggest that hepatic dysfunction in measles is probably not rare and is more frequent and more extensive in adults. However, these abnormalities seem to be subclinical, self-limited and probably with no long-term sequelae.
Abstract 1826: Anthropometric characteristics, physical activity and risk of lymphoid neoplasms in a large US cohort
Authors: Alpa V. Patel, William Ryan Diver, Brenda M. Birmann, Susan M. Gapstur
Journal: Cancer Research (2010)

Abstract Body size, height, and physical inactivity are known to alter immune function and have been hypothesized to increase risk of non-Hodgkin lymphoma (NHL). However, results of other studies are inconsistent and whether these relationships vary by histologic subtypes of NHL is not well-documented. Therefore, we examined measures of body size (BMI, adult weight gain, and BMI at age 18), height, physical activity, and sitting time in relation to risk of NHL overall and within the major subtypes (diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and multiple myeloma (MM)) in the American Cancer Society Cancer Prevention Study II (CPS-II) Nutrition Cohort, a prospective study of cancer incidence and mortality, using information obtained at baseline in 1992. From 1992-2007, 2000 incident NHL cases were identified among 150,189 men and women who were cancer-free at enrollment. Cox proportional hazards modeling was used to compute hazard rate ratios (RR) while adjusting for potential confounders. Obese men and women (BMI &amp;gt; 30) had a 20% higher incidence of all NHL (95% confidence interval (CI) 1.05-1.37) compared to normal weight individuals (BMI 18.5-&amp;lt;25). BMI at age 18 and BMI measured 10-years prior to baseline (in 1982) were also associated with NHL risk (trend p=0.008 and p=0.0003, respectively) in men and women, even after adjustment for baseline BMI. Height was positively associated with overall risk (RR=1.25, 95% CI 1.10-1.43 for sex-specific quintile 5 vs. 1). Associations were similar across all subtypes of NHL examined. Measures of physical activity and sitting time were not associated with risk of NHL or within any specific subtype. These findings suggest that obesity throughout adulthood and greater height may play a role in the etiology of NHL. While more recent obesity may impact immune function or levels of various hormones, height and BMI at age 18 may reflect early-life consequences of nutrition or exposure to growth hormones. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1826.
PERFORATIVE DIVERTICULITIS OF THE COLON
Authors: S. N. Sennett
Journal: BMJ (1931)

Of the conditions which may give rise to an acute abdomen, a perforative diverticulitis of the colon is com- paratively rare, and it is still rarer for the diagnosis to be made with any degree of confidence.Such a case diagnosed correctly oIn clinical grounds was described by Sir I. de C. Wheeler in the British Medical Joulrnial of January 4th, 1930.Recently it was possible for me to recognize a case of perforative diverticulitis with tolerable certainty, as a few days after I had diagnosed diverticulitis with the aid of a barium enema, the patient developed an acute abdomen.The patient, a Norwegian air pilot, aged 40, came to see me on December 29th, 1930.He kad had some pain in the lower abdomen for teni days previously.For the first eight days the pain was not bad, but for the last tw!o days it was very severe and kept him axvake all night.It came in spasms, some of them being St severe as to double him up anid make him shout.The pain was Inot related to food, yet he was afraid to eat lest it came on again.His appetite 'was very good, and he felt quite comfortable in the intervals between the attacks.Ile hadl had similar pains about oie year previously in Norway, but was put on a " diet," and had then no further trouble.D)uring the attacks he found it painful to urinate.Ile had frequency of micturition by day, and at night waked once or twvice.He was also somewhat constipated.. His tongue wvas furred, and there was definite teniderness in the lower abdomen, in botlh iliac fossae, anid in the middle line.The liver and spleen wvere not palpable.He had large external haemorrhoids.
The Adrenocortical, Thyroidal, and Human Growth Hormone Reserve in Sheehan's Syndrome.
Authors: Lillian Haddock
Journal: Annals of Internal Medicine (1969)

s1 May 1969The Adrenocortical, Thyroidal, and Human Growth Hormone Reserve in Sheehan's Syndrome.Lillian Haddock, M.D., F.A.C.P., Luis A. Vega, M.D., Ovidio Rodríguez, M.D., Francisco Aguiló, M.D.Lillian Haddock, M.D., F.A.C.P.Search for more papers by this author, Luis A. Vega, M.D.Search for more papers by this author, Ovidio Rodríguez, M.D.Search for more papers by this author, Francisco Aguiló, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1062_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSheehan's syndrome is the most common cause of hypopituitarism in the indigent medical population of our University Hospital. The endocrine function was thoroughly studied in a group of patients diagnosed after 1960 and in some of the earlier cases.Human growth hormone (HGH) was measured by immunoassay after insulin hypoglycemia, or arginine infusion, or both. Adrenocorticotrophic hormone (ACTH) reserve was measured indirectly by the response to metyrapone; thyroid reserve by the measurement of the 24-hr radioactive iodine uptake; the protein-bound iodine (PBI) before and after thyroid-stimulating hormone (TSH); and the adrenal reserve by the measurement of the daily excretion of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Juan Puerto Rico PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1062-1062KeywordsAdrenocorticotropic hormoneArginineExcretionHuman growth hormoneHypoglycemiaImmunoassaysInsulinProteinsThyroidThyroid-stimulating hormone Issue Published: 1 May 1969 PDF downloadLoading ...
Abstract 636: Role of PALB2 and the BRCA complex in G2/M checkpoint control.
Authors: Srilatha R. Simhadri, Hong Cai, Bing Xia
Journal: Cancer Research (2013)

Abstract Breast cancer tumor suppressors BRCA1, BRCA2 and PALB2 form a complex that promotes faithful DNA repair by homologous recombination (HR). PALB2, the partner and localizer of BRCA2, mediates the physical and functional communication between BRCA1 and BRCA2. PALB2 binds to BRCA1 through its N-terminal coiled-coiled domain, and to the extreme N-terminal region of BRCA2 via its C-terminal WD40 repeats. Recently, it was shown that BRCA2 and PALB2, like BRCA1, play key roles in the maintenance of the G2/M checkpoint. Here, we show that PALB2 also plays a role in the activation of the G2/M checkpoint. Cells in the mitotic phase were scored on the basis of Ser 10 phosphorylation in the histone, H3 before and one hour after ionizing radiation. PALB2-deficient Fanconi anemia (FA-N) cells exhibited a significant defect in G2/M checkpoint activation, which was corrected upon re-expression of wild-type PALB2. This function of the protein appears to be dependent on its binding to both BRCA1 and BRCA2, as PALB2 mutants abrogated for their BRCA1- or BRCA2-binding abilities were unable to correct the checkpoint activation failure. Since TP53 is often mutated in BRCA- and PALB2-associated breast cancers and since FA-N cells express the SV40 T antigen which inactivates TP53, we studied whether TP53 is involved in PALB2-dependent checkpoint activation. However, depletion of PALB2 in isogenic TP53-wildtype and TP53-null HCT-116 colon cancer cells showed similar defects in checkpoint activation. Furthermore, mouse embryonic fibroblasts (MEFs) derived from a Palb2 knock-in strain, in which the endogenous PALB2-BRCA1 interaction is abrogated, also exhibited a defect in G2/M checkpoint activation. In conclusion, our results demonstrate that PALB2 plays an important role not only in the maintenance but also the activation of the G2/M checkpoint, and suggest that BRCA1, PALB2 and BRCA2 function together as a complex in the maintenance of genome integrity. Citation Format: Srilatha R. Simhadri, Hong Cai, Bing Xia. Role of PALB2 and the BRCA complex in G2/M checkpoint control. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 636. doi:10.1158/1538-7445.AM2013-636
Children in Third World slums.
Authors: J. Dobbing
Journal: BMJ (1988)

should be quoted; unfortunately, this is unknown.We think that it is unwise to base an argument for population screening on the findings in a selected population at risk, particularly when the incidence of abnormality in this selected group is lower than in the population as a whole.This would seem to be yet another example of basing a screening thesis (which is a population based activity) on data generated by secondary and tertiary referral, which is a selected clinical activity.
B7-H4 Expression in Human Melanoma: Its Association with Patients' Survival and Antitumor Immune Response
Authors: Dagmar Quandt, Eckhard Fiedler, Diana Boettcher, Wolfgang Ch Marsch, Barbara Seliger
Journal: Clinical Cancer Research (2011)

Abstract Purpose: Cancers have developed a number of strategies to escape immune responses including the differential expression of costimulatory molecules of the B7 family. B7-H3 and B7-H4 have recently been described in different tumor entities but the relevance for melanoma has not yet been studied so far. Experimental Design: Using immunohistochemistry, B7-H3 and B7-H4 expression was studied on 29 melanoma lesions. Survival curves and log-rank tests were used to test the association of protein expression with survival. Cell lines were evaluated for B7-H3 and B7-H4 expression by PCR and flow cytometry. Functional T-cell–tumor coculture assays were carried out with in vitro generated tumor transfectants. Results: B7-H3 and B7-H4 expression was detected in primary tumor lesions (29 of 29 and 28 of 29) and in metastases (28 of 29 and 26 of 29). The numbers of CD68+ macrophages were significantly lower in patients with low B7-H4 expression, whereas CD8+ T-cell infiltrates were independent of expression levels. Furthermore, a survival benefit for patients with B7-H4 low expressing melanoma was found, whereas B7-H3 was not associated with any clinical parameter. All 23 melanoma cell lines analyzed expressed B7-H3 and B7-H4 mRNA and protein, but B7-H4 was restricted to intracellular compartments. On silencing of B7-H3 by specific shRNA tumor-associated antigen–specific T cell responses were unaltered. Overexpression of B7-H4 on melanoma cells did not alter the cytotoxicity of different CD8+ effector cells, but drastically inhibited cytokine production. Conclusions: Our study provides for the first time evidence of B7-H4 expression on melanoma cells as a mechanism controlling tumor immunity which is associated with patients' survival. Clin Cancer Res; 17(10); 3100–11. ©2011 AACR.
Use of Penicillin in the Treatment of Carriers of Beta-Hemolytic Streptococci among Patients with Rheumatic Fever
Authors: Jessamine R. Goerner, Benedict F. Massell, T. Duckett Jones, Mary Meyeserian
Journal: New England Journal of Medicine (1947)

THE danger of hemolytic streptococcus respiratory infection to persons who are susceptible to rheumatic fever is well recognized. Since with present knowledge there are inherent difficulties in evaluating the innocuousness of a given strain, every carrier of beta-hemolytic streptococci must be considered a potential menace to a population of rheumatic-fever patients. Prolonged isolation of such carriers is inadvisable from the psychologic standpoint and is usually impracticable. Hence, means of abolishing the carrier state are desirable.During the administration of sulfonamides to carriers the throat cultures become negative for hemolytic streptococci in some cases, whereas in others the cultures, although remaining . . .