tbuckley/cabot-search huggingface dataset:
Extensive Rhabdomyolysis After Streptokinase Therapy for Acute Myocardial Infarction Demonstrated by Tc-99m PYP Scintigraphy
Authors: LOUISE M. EMMETT, NIDHIKANT C. PATEL, KRISH THANAKRISHNAN, HANS VAN DER WALL, MICHAEL MAGEE, KEVIN C. ALLMAN
Journal: Clinical Nuclear Medicine (1999)

A 76-year-old man with acute inferior myocardial infarction was treated with streptokinase. Two days later, severe rhabdomyolysis developed that was complicated by acute anuric renal failure that required dialysis. His peak serum creatinine kinase level was 85,000 u/l. Large areas of necrotic skin developed on his abdomen and lower limbs. Whole-body scintigraphy performed with 25 mCi Tc-99m PYP revealed extensive abnormal tracer uptake in the major muscle groups of the lower limbs, consistent with acute myocyte injury.
Cefotetan-induced Singultus
Authors: Joseph T. Morris, C. Kenneth McAllister
Journal: Annals of Internal Medicine (1992)

Letters15 March 1992Cefotetan-induced SingultusJoseph T. Morris, MD, C. Kenneth McAllister, MDJoseph T. Morris, MD, C. Kenneth McAllister, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-6-522_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Singultus (hiccups), generally transient, can be disabling. We report a case of singultus associated with the use of cefotetan.A 62-year-old man was being treated with cefotetan, 1.0 g intravenously twice a day, for osteomyelitis of his right foot. After 4 weeks of outpatient therapy, he noted singultus developing within 1 hour of infusion and resolving in 4 to 5 hours. However, severe discomfort, such that he could not eat, remained. Antacids and H2blockers were ineffective. The singultus recurred after each cefotetan infusion, and, 1 week later, the antibiotic treatment was discontinued for 1 day, with...References1. JansenJoostenVingerhoets PEH. Persistent periodic hiccups following brain abscess: a case report. J Neurol Neurosurg Psychiatry. 1990;53:83-4. CrossrefMedlineGoogle Scholar2. Hardo P. Intractable hiccups—an early feature of Addison disease. Postgrad Med J. 1989;65:918-9. CrossrefMedlineGoogle Scholar3. JonesLloydCannon JTL. Persistent hiccups as an unusual manifestation of hyponatremia. J Emerg Med. 1987;5:283-7. CrossrefMedlineGoogle Scholar4. Eisenstadt H. A case of hiccups. JAMA. 1967;202:149. CrossrefMedlineGoogle Scholar5. SeibertAl-Kawas DF. Trimethoprim-sulfamethoxazole, hiccups, and esophageal ulcers. Ann Intern Med. 1986;105:976. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFormation of ω-(4-oxo-1,4-dihydropyridin-2-yl)alkanamides in the Beckmann rearrangement of spiro-fused cycloalkanone oximesCephalosporinsANTIBACTERIAL DRUGSCephalosporinsPossible azithromycin-associated hiccupsDrug-Induced HiccupsCefotetan 15 March 1992Volume 116, Issue 6Page: 522-523KeywordsAntibioticsOsteomyelitisOutpatients Issue Published: 15 March 1992 PDF downloadLoading ...
Legionella and the "New" Pneumonias
Authors: G. ANN HÉBERT
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 August 1980Legionella and the "New" PneumoniasG. ANN HÉBERT, B.S.G. ANN HÉBERT, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-2-374 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Several major points in Dr. Weinstein's editorial (1) should be clarified. The TATLOCK bacterium was never gram-positive (2), and, to my knowledge, gram-negative organisms do not become positive with age. The reverse often occurs, however, within some genera.TATLOCK, HEBA, and the Pittsburgh bacterium (PPA) were not acid-fast in agar-culture smears stained with the Ziehl-Neelsen procedure for mycobacteria used by most microbiology laboratories (2, 3). Pasculle and colleagues (4) reported that PPA in tissue impression smears was not acid-fast when this procedure was used; however, he found that 25% to 50% of the cells retained carbol-fuchsin dye...References1. WEINSTEIN L. The "new" pneumonias: the doctor's dilemma. Ann Intern Med. 1980;92:559-61. Editorial. LinkGoogle Scholar2. HÉBERT G, MOSS C, MCDOUGAL L, BOZEMAN F, MCKINNEY R, and BRENNER D. The rickettsia-like organisms TATLOCK (1943) and HEBA (1959): bacteria phenotypically similar to but genetically distinct from Legionella pneumophila and the WIGA bacterium. Ann Intern Med. 1980;92:45-52. LinkGoogle Scholar3. HÉBERT G, THOMASON B, HARRIS P, HICKLIN M, and MCKINNEY R. "Pittsburgh pneumonia agent": a bacterium phenotypically similar to Legionella pneumophila and identical to the TATLOCK bacterium. Ann Intern Med. 1980;92:53-4. LinkGoogle Scholar4. PASCULLE A, MYEROWITZ R, and RINALDO C. New bacterial agent of pneumonia isolated from renal-transplant recipients. Lancet. 1979;2:58-61. CrossrefMedlineGoogle Scholar5. WATTS J, HICKLIN M, THOMASON B, CALLAWAY C, and LEVINE A. Fatal pneumonia caused by Legionella pneumophila, serogroup 3: demonstration of the bacilli in extrathoracic organs. Ann Intern Med. 1980;92(Part 1):186-8. LinkGoogle Scholar1. WEINSTEIN L. The "new" pneumonias: the doctor's dilemma. Ann Intern Med. 1980;92:559-61. Editorial. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: G. ANN HÉBERT, B.S.Affiliations: Center for Disease Control Atlanta, GA 30333 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLegionella micdadei (Pittsburgh Pneumonia Agent) Infection in Nonimmunosuppressed Patients with PneumoniaMARK D. ARONSON, M.D., ANTHONY L. KOMAROFF, M.D., A. WILLIAM PASCULLE, Sc.D., RICHARD L. MYEROWITZ, M.D. 1 August 1980Volume 93, Issue 2Page: 374-375KeywordsCellsLegionellaMicrobiologyMycobacteriaPneumonia ePublished: 1 December 2008 Issue Published: 1 August 1980 PDF downloadLoading ...
EDEMATOUS LARYNGITIS; WITH REPORT OF CASES.
Authors: JOSEPH S. GIBB
Journal: JAMA (1901)

The term edematous laryngitis is intended to describe a disease the underlying process of which is inflammation of a mucous surface, attended by serous transudation into the submucous tissues. To this disease many names have been applied, among which may be mentioned: Phlegmonous laryngitis, abscessus laryngis, edema of the larynx, erysipelas of the larynx, etc. Semon, in a paper on the subject, has called attention to the confusion which has resulted from the multiplicity of terms, and made a very commendable effort to simplify the matter by classifying certain types. Much of the confusion which certainly does exist in the literature could be obviated if a distinction was sharply drawn between cases in which the symptom edema is present without inflammation, or, as Rice denominates these, the passive cases, and those in which inflammation of the mucous surfaces is an active and conspicuous feature. It is obvious from a study
Biotechnology Industry Calls for Active US Role
Authors: Charles Marwick
Journal: JAMA (1994)

SIGNS that the biotechnology industry is not growing as fast in the mid 1990s as it did in the 1980s have the industry's members, academic leaders, and investors worried. They have joined in an effort to halt any further erosion and to shape a national agenda to ensure United States preeminence in biotechnology. If the meeting they held in Washington, DC, described as the National Biotechnology Summit, did not exactly allay the industry's fears for the future, it did examine some of the problems the industry faces.  Speaker after speaker pointed with alarm to cuts in federal funding for medical research, delays in drug approval, and doubts about the way new drug price controls, likely to be incorporated into health system reform legislation, may work.  Expensive Toys?  More than one speaker called up the specter of an administration that they say views new medical technologies as expensive toys to be
Efficacy of Rifampin in Treatment of Meningococcal Carriers
Authors: William B. Deal, Eugene Sanders
Journal: New England Journal of Medicine (1969)

Since the emergence of sulfadiazine resistance among meningococci, no antimicrobial agent has been uniformly effective in eradication of these micro-organisms from carriers. Rifampin, a new antibacterial agent with a high degree of activity against meningococcal growth in vitro, was evaluated in a double blind-placebo study in known meningococcal carriers. Administration of 600 mg daily for four days reduced the carrier rate by 93.3 per cent, and this effect was sustained for four weeks. During the study period, the carrier rate among subjects receiving placebo fell only 13.4 per cent. Rifampin appears superior to currently available antimicrobial agents in elimination of meningococci from known carriers.
Medicine: Essentials of Clinical Practice
Authors: William R. Best
Journal: JAMA (1984)

Medical students are the intended audience of this Boston University School of Medicine work, the first edition of which was published in 1970, under the leadership of Chester Keefer. It should also prove quite useful to residents, practicing physicians, and other health professionals. Emphasis is on the essentials, not the minutiae of practice. It has about one third the content of texts such as Cecil or Harrison , but emphasizes those aspects that constitute the core of medicine. By spending an hour a day, the reader should be able to digest this material during a 12-week medicine clerkship. Thereafter, it will serve as a useful general reference.  The introduction to each organ system includes a list of learning objectives, indicating types of clinical situations for which the student should develop an approach and facility. The reader is guided through several patient treatment problems at the end of each organ system, keyed
Lamivudine-Zidovudine Treatment and Clinical End Points-Reply
Authors: Schlomo Staszewski
Journal: JAMA (1996)

<h3>In Reply.</h3> —The primary objective of the trial described in our article was to determine the benefit of combination treatment with zidovudine and lamivudine relative to zidovudine monotherapy on changes in CD4 cell counts and measures of HIV-1 viral load. The trial was not statistically powered to detect differences between treatment arms in progression to CDC category C (acquired immunodeficiency syndrome) events or death. However, the lower rate of clinical progression in the combination therapy arms in the trial is consistent with the results of a meta-analysis of trials of zidovudine combined with lamivudine that showed a 66% reduction in progression to CDC category C events,<sup>1</sup>and in the recently reported CAESAR trial of combined zidovudine and lamivudine, which has shown a 54% reduction in progression to CDC category C/death end points for patients adding lamivudine to zidovudine-containing regimens.<sup>2</sup>
Prevalence and Predictors of Diabetes After Lung Transplantation: A Prospective, Longitudinal Study
Authors: Kathryn L. Hackman, Gregory I. Snell, Leon A. Bach
Journal: Diabetes Care (2014)

To determine incidence and prevalence of diabetes mellitus (DM) after lung transplantation (LTx), identify risk factors for persistent DM after LTx, and determine its effect on survival.This was a prospective, longitudinal study comparing DM status before and after LTx using oral glucose tolerance tests (OGTTs). DM prevalence and changes in metabolic control over time were determined. Risk factors for persistent DM and survival differences by DM status were assessed.Between August 2010 and December 2012, 156 patients underwent LTx. DM prevalence after 3, 12, and 24 months was 47%, 44%, and 40%, respectively. A further 20%, 11%, and 7% had impaired glucose tolerance and/or impaired fasting glucose. Incidence of new-onset DM after transplant (NODAT) was 32%, 30%, and 24% after 3, 12, and 24 months. Nonfasting insulin levels and second phase insulin release fell 3 months after transplant (Tx) but returned to baseline by 2 years. The only risk factors for NODAT were 1- and 2-h glucose levels on pre-Tx OGTT (OR 1.73 [95% CI 1.19-2.50], P = 0.004, and 1.84 [1.22-2.77], P = 0.004, respectively). Survival was reduced in patients with DM at study end versus those without (estimated mean 979 days [95% CI 888-1,071] vs. 1,140 days [1,070-1,210], P = 0.023).Most patients had dysglycemia during the first year after LTx, and 32% developed NODAT. Hyperglycemia was caused both by β-cell dysfunction and by insulin resistance. Only pre-Tx OGTT glucose levels predicted persistent NODAT. As DM was common and associated with reduced survival, early detection and management of DM in LTx recipients are warranted.
Health risks associated with bathing in sea water: Author's reply
Authors: R Balarajan, V S. Raleigh, P Yuen, D Machin
Journal: BMJ (1992)

pesticides have yielded inconclusive results about the risks presented.'Effective safety margins, based on the best risk assessment models and full information, are necessary in making decisions regarding environmental health policy because of this uncertainty.Yet, remarkably, no published comprehensive British environmental health impact assessments or audits of pesticides seem to exist.The British process of registering pesticides does not entail effective audit or environmental health impact assessments.Potential environmental health effects of pesti- cides must be assessed from the start of the extraction process for basic chemicals to the end of the waste disposal process and residue chain.This does not happen.Information on the pollution effects and health effects of energy used in manu- facturing and transporting materials for pesticides is not readily available.Data on resistance of pests and damage to beneficial predators on pests resulting from use of pesticides are lacking.Knowledge of possible pollution effects of pesticides is still limited.Pesticides occur in rain6 and fog" and as pol- lutants of materials and atmospheres in various buildings.Researchers have found many pesticide residues in the air and house dust of homes.8A study recently showed that over nine months the potential exposure of a crawling infant to flea pesticides could exceed the World Health Organisation's no observable effect levels.' Full audits and environmental health impact assess- ments of pesticides would identify such potential sources of pollution, would ensure a better assess- ment ofany chemical's impact on the environment, and should be introduced into all relevant legislation in the United Kingdom.This requires active medical participation to monitor and predict the effects of environmental pollution on health and to ensure that Britain endorses the highest environ- mental standards.'
Health watchdog vows to act over marketing of products to new mothers while in hospital
Authors: A. Gulland
Journal: BMJ (2013)

The Care Quality Commission has promised to take action against hospitals where a patient’s dignity or privacy has been breached because they have been targeted by sales representatives while on the wards.

The CQC made the undertaking after the health minister, Dan Poulter, said that hospitals should “get a grip” over sales people marketing products to new mothers in hospital.

Poulter told the Independent on Sunday that the commission should take action against hospitals that did not “ensure the protection of women’s privacy and dignity.”1

A CQC spokesman said that it …
NHS trust is losing out to private investors, says watchdog
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

The profits of a private company involved in an early private finance initiative (PFI) deal to pay for a new hospital have soared to “unacceptable” levels, says the public finance watchdog.

The private sector consortium Octagon pushed up the profits for its investors by refinancing the Norfolk and Norwich PFI hospital project. The rate of return rose from a predicted 19% to 60%, says the parliamentary Public Accounts Committee in a report. The deal made £82m (荤120m; $150m) for its investors. And while the trust stands to make £34m, it will have to pay the consortium up to £257m to end the contract with Octagon early.

The contract between the …
Herpetic bronchitis with a broncho-oesophageal fistula.
Authors: D P Remy, T V Kuzmowych, P K Rohatgi, L G Ortega
Journal: Thorax (1995)

Tracheobronchitis and oesophagitis due to herpes simplex virus (HSV) are rare. Tracheo-oesophageal fistula due to HSV oesophagitis has been described in the immunocompromised host. A case is reported of a broncho-oesophageal fistula which developed secondary to herpetic bronchitis in an apparently immunocompetent patient.
Book Review Textbook of Pharmacology Edited by Cedric M. Smith and Alan M. Reynard. 1213 pp., illustrated. Philadelphia, W.B. Saunders, 1992. $45. ISBN 0–7216–2442–1 . Pharmacology (Lippincott's Illustrated Reviews.) Edited by Richard A. Harvey and Pamela C. Champe. 458 pp., illustrated. Philadelphia, J.B. Lippincott, 1992. $24.95. ISBN 0–397–51039-X .
Authors: Louis Shuster
Journal: New England Journal of Medicine (1992)
"Colomycin" Treatment of Klebsiella Aerogenes Infection of Urinary Tract in Paraplegia
Authors: E. W. Colley, H. L. Frankel
Journal: BMJ (1963)

ENURESISBRDICAISHUNA ENURESIS ~~~~~~~~~~~~MEDICALJOURNAL with these problems a poor prognosis provided that the disorder is treated in a reasonable way. SummaryOf III children referred to hospital with enuresis who were comprehensively evaluated, 93 were followed up after a period of five years.It was possible, therefore, to determine the number who remained wet five years after initial investigation and treatment and to ascertain the time of cessation of bed-wetting in those who had become dry.At initial evaluation no single causal factor accounted for enuresis.A positive family history of the condition was frequent and abnormalities in the electroencephalogram were present in 84%.The majority of the children came from stable homes and most of them did not show marked emotional disturbances.At follow-up 93 children were traced and interviewed: 37 (60%) of the 62 boys and 23 (74%) of the 31 girls had become "dry."Age was more strongly associated with cure than any other factor.A greater percentage of those entering the survey at 10+ years had become " dry " more frequently than of those investigated earlier.Half the series were dry by the age of 12 years and three-quarters by 14-15 years.Children whose bed-wetting persisted after puberty tended to be duller than those becoming dry earlier, but no correlation was shown between persistence of enuresis and deprivation, maladjustment, or abnormalities of the bladder neck.The study has failed to reveal a constant, single cause of bed-wetting, nor has it indicated any particular factor among those commonly considered which is associated with the persistence of enuresis.At present, therefore, it is reasonable to regard enuresis as a delayed development or loss of bladder control which may be affected by many factors, physical and psychological.We are grateful to the consultants at the Bristol Royal Hospital for Sick Children for their co-operation in permitting their patients to be included in this study and also to the Board of Governors of the United Bristol Hospitals for a research grant.
Influence of metabolism in skin on dosimetry after topical exposure.
Authors: R L Bronaugh, S W Collier, S E Macpherson, M E Kraeling
Journal: Environmental Health Perspectives (1994)

Metabolism of chemicals occurs in skin and therefore should be taken into account when one determines topical exposure dose. Skin metabolism is difficult to measure in vivo because biological specimens may also contain metabolites from other tissues. Metabolism in skin during percutaneous absorption can be studied with viable skin in flow-through diffusion cells. Several compounds metabolized by microsomal enzymes in skin (benzo[a]pyrene and 7-ethoxycoumarin) penetrated human and hairless guinea pig skin predominantly unmetabolized. However, compounds containing a primary amino group (p-aminobenzoic acid, benzocaine, and azo color reduction products) were substrates for acetyltransferase activity in skin and were substantially metabolized during absorption. A physiologically based pharmacokinetic model has been developed with an input equation, allowing modeling after topical exposure. Plasma concentrations in the hairless guinea pig were accurately predicted for the model compound, benzoic acid, from in vitro absorption, metabolism, and other pharmacokinetic parameters.
Lifestyles Matter in the Prevention of Type 2 Diabetes
Authors: Matti Uusitupa
Journal: Diabetes Care (2002)

The incidence of type 2 diabetes is rapidly increasing worldwide due to the increasing occurrence of obesity and sedentary lifestyle. Type 2 diabetes is no longer confined to middle-aged and elderly people but is increasingly common among young people and even children (1,2). Type 2 diabetes constitutes a major health problem in both developed and developing countries, and with obesity it is becoming one of the largest challenges to health care systems. Therefore, any measures to prevent or delay the development of diabetes are urgently needed.

There is a great deal of evidence that both genetic and environmental factors are of importance in the pathogenesis of type 2 diabetes. While the genetic factors are still poorly understood, numerous studies have shown that obesity (central obesity in particular), physical inactivity (3), high-fat diet, and diet rich in saturated fatty acids increase the risk of diabetes (4,5). Furthermore, based mainly on epidemiological studies, low intakes of dietary fiber, low-glycemic carbohydrates, and whole grain cereals have been shown to increase the risk of type 2 diabetes (5).

Type 2 diabetes is preceded by a long period of impaired glucose tolerance (IGT) or milder disturbances in glucose metabolism. These disturbances in glucose metabolism and insulin resistance syndrome or metabolic syndrome, characterized by a clustering of risk factors, are much more common than type 2 diabetes and carry an increased risk not only for type 2 diabetes but also for cardiovascular morbidity and mortality, even in early phases of impaired glucose metabolism (6,7). Therefore, the …
Colouring Matter of the Skin: In the Dark Races of Mankind
Authors: None Glover
Journal: BMJ (1840)

the following letters will show.Dr. Franz will now, pro- bably, deny the existence of such persons as Dr. Hingeston or Mr. Wardrop, jun.; or, being driven to the wall, will, perchance, sustain that no such day as the 7th of April ever existed.Had Dr. Franz conducted this controversy with anything approaching to fairness, we