tbuckley/cabot-search huggingface dataset:
Use of omentum for stroke: dream or reality?
Authors: W. A. Check
Journal: JAMA (1982)

Medicine has little to offer patients who have long-standing neurological deficits as a result of stroke. Even most centers that do cerebral artery bypass surgery choose patients who have recently suffered a completed stroke and have no major residual deficits. In the last few years, Harry Goldsmith, MD, professor of surgery, Dartmouth Medical School, Hanover, NH, has stepped into this no-man's-land with an intriguing new brain revascularization procedure called omental transposition. In this operation, the abdomen is opened and the omentum freed from some of its attachments and extensively lengthened. The intact membrane is then passed through a subcutaneous tunnel along the chest and neck to just behind the ear, brought out under a skin flap, and applied to the surface of the brain through an opening in the skull. According to Goldsmith, the tremendous vascularity of the omentum makes it ideal for restoring blood supply to ischemic areas, such
Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score
Authors: Federico Pappalardo, Marina Pieri, Teresa Greco, Nicolò Patroniti, Antonio Pesenti, Antonio Arcadipane, V. Marco Ranieri, Luciano Gattinoni, Giovanni Landoni, Bernhard Holzgraefe, Gernot Beutel, Alberto Zangrillo
Journal: Intensive Care Medicine (2012)
The Effects of Alcoholism on Skeletal and Cardiac Muscle
Authors: Alvaro Urbano-Marquez, Ramon Estruch, Francisco Navarro-Lopez, Jose Maria Grau, Lluis Mont, Emanuel Rubin
Journal: New England Journal of Medicine (1989)

To determine the prevalence of alcoholic myopathy and cardiomyopathy, we studied a group of 50 asymptomatic alcoholic men (mean age, 38.5 years) entering an outpatient treatment program. Studies performed included an assessment of muscle strength by electronic myometer, muscle biopsy, echocardiography, and radio-nuclide cardiac scanning, with comparison to healthy control subjects of similar age. The patients' mean (±SEM) daily alcohol consumption was 243± 13 g over an average of 16 years. These patients had no clinical or laboratory signs of malnutrition or electrolyte imbalance. Forty-two percent of the patients, as compared with none of the controls, had strength of less than 20 kg as measured in the deltoid muscle. Muscle-biopsy specimens from 23 patients (46 percent) had histologic evidence of myopathy. In the cardiac studies, when the alcoholic patients were compared with 20 healthy controls, the patients had a significantly lower mean ejection fraction (59 vs. 67 percent), a lower mean shortening fraction (33 vs. 38 percent), a greater mean end-diastolic diameter (51 vs. 49 mm), and a greater mean left ventricular mass (123 vs. 106 g per square meter of body-surface area). One third of the alcoholics had an ejection fraction of 55 percent or less, as compared with none of the controls. Endomyocardial biopsy specimens from six patients with ejection fractions below 50 percent showed histologic changes of cardiomyopathy. The estimated total lifetime dose of ethanol correlated inversely with muscular strength (r = -0.65; P<0.001). In an analysis that also included six patients with symptomatic alcoholic cardiomyopathy, the estimated total lifetime dose of ethanol correlated inversely with the ejection fraction (r = -0.58; P<0.001) and directly with the left ventricular mass (r = 0.59; P<0.001). We conclude that myopathy of skeletal muscle and cardiomyopathy are common among persons with chronic alcoholism and that alcohol is toxic to striated muscle in a dose-dependent manner. (N Engl J Med 1989; 320: 409–15.)
Problems associated with L.S.D.
Authors: D. S. Freestone
Journal: BMJ (1968)

MEDBIJO 705 if the subject has an intercurrent infection or has taken alcohol or other drugs.Prolonged unconsciousness also results from taking mixtures of tranquillizers and hypnotic drugs when alcohol or dexamphetamine or barbiturates are ingredients.I agree with Dr. H. J. S. Matthew (10 February, p. 380) that the evidence is extremely confusing.It would be interesting to know if people who have given L.S.D.-25 therapeutically have ever encountered prolonged coma.The first case of chronic psychosis following therapeutic L.S.D.-25 which I ever saw was a man who later died of leukaemia.This has given me much food for thought in the light of the present research on chromosomal aberrations after L.S.D.-25, and might be worth pursuing.I am, etc., London W.2.
Gastrointestinal bleeding in Romford
Authors: W R Burnham, J D O'Brien
Journal: BMJ (1986)

Patients attending without consulting general practitioner.A major factor influencing preferential attend- ance at an accident and emergency department is known to be the distance.of the patient from the hospital.General practitioners practising near to accident and emergency departments may expect a greater proportion ofthe minor traumas to be dealt with there.Sixty two general practitioners practise in Dar- lington Health Authority.If they dealt with these cases of minor trauma, and assuming an equal distribution ofworkload, each general practitioner could expect about 30 extra cases to deal with per month.Over 25% of emergencies occurred out of hours-600 pm to 800 am, with about 10% between 1100 pm and 700 am.Each general practitioner could therefore expect to receive about 10 calls "out ofhours" a month and to be disturbed from his or her bed three to four times a month.The general practitioner covering for several col- leagues could expect a substantial out of hours work commitment.Do general practitioners have the time?Do they have the facilities?
Martin Ware Sabiha Al-Dabbagh Francis William Blacklay John Antony Boucher John Halliday Garson Kenneth Michael Hay Ronald Sherrington Ogborn Susan Marion Wood
Authors: D. Swinscow, T. Smith, S. Khulusi, P. Blacklay, D. Cooper, R. Carr, A. Evans, T. Ogborn, K. Jones
Journal: BMJ (1998)

Martin was born into a family which had had a medical man in every generation since the middle of the 18th century.One ancestor he was proud of was Sir George Baker, president of the Royal College of Physicians and describer of the Derbyshire colic, due to chronic lead poisoning.
The Potential Role of Proteasome Inhibitors in the Treatment of Lung Cancer
Authors: Paul A. Bunn
Journal: Clinical Cancer Research (2004)

Bortezomib (PS-341, Velcade, Millennium Pharmaceuticals, Cambridge, MA) is a novel inhibitor of the proteasome. The proteasome plays a critical role in the degradation and, therefore, regulation of many proteins involved in cell cycle regulation, apoptosis, and angiogenesis. Bortezomib inhibits the growth of lung cancer cell lines in vitro and in vivo in athymic nude mouse xenografts. Bortezomib produces a G(2)-M arrest, increases in cyclin A and cyclin B, increases in p21, and increases apoptosis in these preclinical models. Phase I studies established that a dose of 1.4 mg/m(2) given i.v. on days 1, 4, 8, and 11 of a 3-week cycle produced acceptable toxicity and serum levels that resulted in proteasome inhibition. Phase II studies showed high-response rates in refractory multiple myeloma. These response rates were sufficiently high to allow accelerated approval of bortezomib by the Food and Drug Administration for this indication. Phase II trials in both non-small cell lung cancer and small cell lung cancer are in progress. A number of Phase I combination studies are also underway. Hopefully, bortezomib will show sufficient activity in lung cancer to improve survival in this dread disease.
The Risk Taken in Driving Under the Influence of Alcohol
Authors: J. Cohen, E. J. Dearnaley, C. E. M. Hansel
Journal: BMJ (1958)

The hazards of inducing anaesthesia in patients with a full stomach are now widely appreciated, and for this reason the pre-operative preparation of diabetic subjects with oral glucose is deprecated.Other problems which anaesthetists may encounter are the incompatibility of pitocin with light cyclopropane anaesthesia and the pos- sibility of citrate intoxication as a differential diagnosis for cardiovascular collapse after massive transfusion of stored blood.In very few of the cases reported did the anaesthetist know of the use of various drugs before operation, or associate hypotension or prolonged unconsciousness with any form of routine medical treatment.It is hoped that this publication will focus the attention of all medi- cal practitioners on the fact that during anaesthesia un- expected adverse effects may be produced by drugs which do not appear to have any side-effects in the conscious subject.It is to be expected that many addi- tions to the list of drugs discussed above will be noted in the future.I am grateful to Professor C. A.
Isolation and characterization of native Cry j 3 from Japanese cedar (<i>Cryptomeria japonica</i>) pollen
Authors: T. Fujimura, N. Futamura, T. Midoro‐Horiuti, A. Togawa, R. M. Goldblum, H. Yasueda, A. Saito, K. Shinohara, K. Masuda, K. Kurata, M. Sakaguchi
Journal: Allergy (2007)

Japanese cedar (Cryptomeria japonica) pollinosis is the most prevalent allergy in Japan. Recently, the Japanese cedar pollen allergen Cry j 3 was cloned as a homologue of Jun a 3, which is a major allergen from mountain cedar (Juniperus ashei) pollen. However, native Cry j 3 has not been isolated and there are no reports on its allergenic activity. The aims of this study were to isolate native Cry j 3 and assess its immunoglobulin E (IgE)-binding capacity in patients with Japanese cedar pollinosis.Native Cry j 3 was purified from Japanese cedar pollen by multidimensional chromatography. We assessed the IgE-binding capacity using sera from patients allergic to Japanese cedar pollen by immunoblot analysis and ELISA. Moreover, we assayed the capacity of Cry j 3 to induce histamine release from the patients' leukocytes. We cloned cDNA corresponding to purified Cry j 3 from a cDNA library of Japanese cedar pollen.We isolated native Cry j 3 as a 27-kDa protein. The IgE-binding frequency of Cry j 3 from the sera of patients allergic to Japanese cedar pollen was estimated as 27% (27/100) by ELISA. Cry j 3 induced the release of histamine from leukocytes. We cloned the cDNA and named it Cry j 3.8. Cry j 3.8 cDNA encoded 225 amino acids and had significant homology with thaumatin-like proteins.Cry j 3 is a causative allergen in Japanese cedar pollinosis and may play crucial roles in the cross-reactivity with oral allergy syndrome.
Induction of Immune Tolerance to Factor VIII in Hemophiliacs With Inhibitors
Authors: Nadia P. Ewing
Journal: JAMA (1988)

Induction of immune tolerance in patients with severe hemophilia A and inhibitors to factor VIII was attempted by daily infusion of 50 U of factor VIII per kilogram of body weight without adjunctive immunosuppressive drugs. Modest initial anamnestic elevation of inhibitor levels occurred in six patients within the first month of therapy; inhibitor levels then fell sharply. The other six patients had no increase in inhibitor levels while on the study protocol. Inhibitors became undetectable within one to ten months in nine of the patients; they now receive smaller and less frequent infusions of factor VIII to maintain suppression. Inhibitors were not eradicated in three patients, who had the highest baseline and historic inhibitor levels. Ten patients gave consent for human immunodeficiency virus (HIV) testing; three had no antibody to HIV at the outset. Two of these patients seroconverted while on the protocol, one of whom had received only donor-screened, heat-treated factor VIII. Thus, the benefits of inhibitor suppression must be weighed against the risks of HIV seroconversion or transient elevation of inhibitor levels, as well as against the cost of the factor concentrate used. (<i>JAMA</i>1988;259:65-68)
Prevalence and Control of Diabetes and Impaired Fasting Glucose in New York City
Authors: Asqual Getaneh, Sally Findley
Journal: Diabetes Care (2009)

We read the article by Thorpe et al. in Diabetes Care (1) with great interest. We would like to advocate for reporting on the differential prevalence of cardiovascular risks within the Hispanic population. New York City Hispanics represent four regions (North America, Central America, the Caribbean, and South America), with people from over 12 countries but primarily Puerto Rico (33.3%), the Dominican Republic (25.8%), Mexico (12.4%), Ecuador (8.6%), and Columbia (4.7%) (2). This heterogeneous population is influenced by a wide spectrum of genetic and environmental factors, and each group potentially contributes to the overall prevalence of diseases such as diabetes and hypertension …
Imaging of hepatocellular carcinoma patient-derived xenografts using 89Zr-labeled anti-glypican-3 monoclonal antibody
Authors: Xiaoyang Yang, Hongguang Liu, Chris K. Sun, Arutselvan Natarajan, Xiang Hu, Xiaolin Wang, Mark Allegretta, Ronald D. Guttmann, Sanjiv S. Gambhir, Mei-Sze Chua, Zhen Cheng, Samuel K. So
Journal: Biomaterials (2014)
<i>Untitled</i>
Authors: Jeanette M. Smith
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STUDIES ON THE SPECIFIC CHARACTERISTICS OF SYPHILITIC BLOOD PROTEINS
Authors: S. T. Walton
Journal: The Journal of Experimental Medicine (1931)

THESE EXPERIMENTS SHOW: 1. That the surface tension of normal blood serum is considerably lowered by standing undisturbed for a period of 1 hour (time-drop). 2. That the greatest time-drop recorded is with serum diluted approximately 10,000 times in fresh serum, and 50,000 times in heated serum. 3. That immune serum is not affected in the same manner by heat as is normal serum. Syphilitic serum and anti-sheep cell rabbit serum behave similarly in this respect. 4. That serum albumin is much more readily soluble in alkaline buffer solutions than globulin is, and that globulin from normal serum ionizes more than that from syphilitic serum. Further investigations are being made in an effort to determine why the proteins aggregate or dissociate under the influence of the factors under consideration.
Half of "ideal" families are now below poverty line, professor says
Authors: M. Limb
Journal: BMJ (2015)

A leading expert in health inequalities has condemned the scale of poverty among families in England.

Michael Marmot, director of the Institute of Health Equity at University College London, said that in 2011-12 there were more people in poverty in households where at least one adult was working than in workless households. Meanwhile net disposable income per person had not recovered to its 2008 level.

He said, “Take the Daily Mail model family—one adult working outside the home for pay, one adult not working for pay staying home, and two children—51% are in poverty. Got that? The perfect, ideal family: 51% are below the poverty line.”

He said that people on low pay were “not skivers or scroungers or feckless or irresponsible or the worthless poor,” while very few people could be said to be “living the life of Riley” on welfare benefits. “They’re not paid enough to have a life that people in Britain think that everyone in Britain should …
Percutaneous Balloon Valvuloplasty: A New Method for Treating Congenital Pulmonary-Valve Stenosis
Authors: Jean S. Kan, Robert I. White, Sally E. Mitchell, Timothy J. Gardner
Journal: New England Journal of Medicine (1982)

TRANSLUMINAL balloon angioplasty has been increasingly accepted as a nonsurgical technique for dilatation of stenotic arteries in the peripheral, renal, and coronary circulations.1 2 3 4 5 6 The physical principles governing balloon angioplasty7 depend on transmission of a controlled radial force through a rigid balloon. The characteristics of the stenotic tissue determine the effectiveness of the dilatation process.Application of the balloon-dilatation principle to intracardiac valves has not been described. However, Semb et al. have relieved congenital pulmonary-valve stenosis by pulling a carbon dioxide-filled balloon from the pulmonary artery to the right ventricle.8 We thought that balloon valvuloplasty of the congenitally stenotic pulmonary valve . . .
Hyaline articular cartilage dissected by papain: light and scanning electron microscopy and micromechanical studies.
Authors: P O'Connor, J D Brereton, D L Gardner
Journal: Annals of the Rheumatic Diseases (1984)

Papain was used to digest the hyaline femoral condylar cartilages of 30 adult Wistar rats. Matrix proteoglycan degradation was assessed by the light microscopy of paraffin sections stained with toluidine blue. The extent of surface structural change was estimated by scanning electron microscopy, and the structural integrity of the hyaline cartilage tested by the controlled impact of a sharp pin. The results demonstrated an early loss of cartilage metachromasia, increasing with time of papain digestion, and an alteration in the shape of the cartilage splits produced mechanically. Accompanying the loss of matrix material was a conspicuous sequence of morphological changes in cartilage surface structure. The results confirm a close relationship between matrix integrity, mechanical properties, and fine structure.
Medicines Control Agency slated by Commons committee
Authors: D. Singh
Journal: BMJ (2003)

The former Medicines Control Agency has received a damning blow from the House of Commons Committee of Public Accounts.

The committee's report, Safety, Quality, Efficacy: Regulating Medicines in the UK , criticises the agency for its “lack of dynamism” in improving public health and for its “non-existent” public profile, which made it difficult for it to function as a provider of safety information.

The agency was, until earlier this year, responsible for protecting public health by ensuring the safety, quality, and efficacy of the one billion medicines that are prescribed …
Hemolytic uremic syndrome in a patient with small cell lung cancer
Authors: Louis Avvento, Sandra Gordon, Jeffrey M. Silberberg, M. Hosein Zarrabi, Stanley Zucker
Journal: American Journal of Hematology (1988)

Abstract Hemolytic uremic syndrome is a rare entity in patients with carcinoma and presents with a triad of renal insufficiency, microangiopathic hemolytic anemia, and thrombocytopenia. We report this syndrome for the first time in a patient with small cell lung carcinoma. Spontaneous platelet aggregation of washed normal platelets was demonstrated using patient plasma. Circulating immune complex levels were not elevated. The entity completely resolved after treatment with plasma, vincristine, aspirin, and dipyridamole.
Abstract 2683: Identification of tumor antigens in neu transgenic mice as diagnostic targets for the early detection of human breast cancer
Authors: Jianning Mao, Jon Ladd, Mei Wu, Ekram Gad, Hailing Lu, Samir Hanash, Mary Disis
Journal: Cancer Research (2011)

Abstract Tumor antigens, expressed early in disease, which can induce specific antibody response could serve as biomarkers for early detection of human breast cancer. However, the ability to obtain sera from women prior to the development of breast cancer is limited, which makes it difficult to identify early antigens directly from breast cancer patients. Transgenic mouse models have been proved to demonstrate similar antigen repertoire to breast cancer patients. Therefore, we propose to identify early tumor antigens in neu transgenic mice and use them as diagnostic targets for early detection of human breast cancer. We have collected serial sera from neu transgenic mice, sera collected before the animals develop palpable tumor “pre-diagnostic sera”. With serological analysis of recombinant cDNA expression libraries (SEREX) approach, we were able to identify nine tumor antigens from pre-diagnostic sera, Rpl5, TNFaip3/A20, Pdhx, Otud6b, Stk39, Zfp238, Dnajc10, Lgals8 and Vps35. These antigens demonstrated detectable IgG antibody response prior to tumor development in neu transgenic mice. IgM is the first antibody to be produced during a humoral immune response, so we questioned whether including antigen specific IgM with IgG responses could achieve a better diagnostic performance. Firstly, we analyzed receiver-operating-characteristic (ROC) curves of these antigens by IgG and IgM ELISA analysis in neu transgenic mice and 26 FVB control mice. By combining IgG and IgM ELISA, we were able to achieve a higher AUC: Otud6b and Stk39 show an AUC of 0.882, and adding Lgals8 IgG ELISA to this panel can achieve an AUC of 0.924 in discriminating cases from control mice. We documented that these autoantibodies are also detectable in the serum of women with breast cancer and then screened a panel of sera derived from the Women's Health Initiative cohort (samples obtained 6-18 months prior to the development of breast cancer) and case matched controls. We evaluated serum for the presence of IgG and IgM specific autoantibodies to Pdhx, Otud6b, and Stk39. With both IgG and IgM ELISA analysis, a panel combining the three antigens demonstrates an AUC of 0.633 in patients diagnosed within 5 month and an AUC of 0.688 in patients diagnosed within 5-18 month of the blood draw. In summary, we conclude that tumor antigens identified in neu transgenic mouse model can be used for early detection and diagnosis of breast cancer in women. The combination of antigen specific IgG and IgM antibodies may enhance the sensitivity of the assay for early detection. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2683. doi:10.1158/1538-7445.AM2011-2683
Recovery of Epstein–Barr Virus from Genital Ulcers
Authors: Joseph Portnoy, Gerald A. Ahronheim, Felicia Ghibu, Bya Clecner, Jean H. Joncas
Journal: New England Journal of Medicine (1984)

INFECTIOUS mononucleosis is the best-known syndrome associated with primary infection by the Epstein–Barr virus (EBV). A variety of cutaneous and mucosal manifestations are recognized, but genital lesions have only rarely been described in infectious mononucleosis.1 , 2 We describe an otherwise healthy young woman in whom painful genital ulcers developed during an episode of serologically and virologically confirmed primary infectious mononucleosis. None of the usual causes of genital ulceration were found, and EBV was recovered from the lesions.Case ReportA previously healthy 23-year-old woman noted the onset of fatigue at about the end of August 1982. On September 16 she began . . .
Parathyroid Crisis in a Child
Authors: Ralph F. Reinfrank
Journal: JAMA (1961)

At the age of 13 years, after 2 years of illness, a girl was hospitalized for abdominal pain, vomiting, weakness, and lethargy. A clue to the diagnosis was the finding of hypercalcemia (21.8 mg. per 100 ml. of serum). Surgical removal of a parathyroid adenoma from the right lobe of the thyroid was followed by prompt clinical improvement. Physical recovery was accompanied by a remarkable change in the personality of the child, who became bright and alert, thereafter did extremely well in school, and resumed normal social activity.