tbuckley/cabot-search huggingface dataset:
Physicians and Patient Spirituality
Authors: Gerald P. Bodey
Journal: Annals of Internal Medicine (2001)

Letters7 August 2001Physicians and Patient SpiritualityGerald P. Bodey, MDGerald P. Bodey, MDThe Woodlands, TX 77381 (Bodey)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-3-200108070-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. John Graner's letter (1) regarding not bringing religion into the “marketplace” reflects a lack of knowledge of Christianity (and some other religions). Christian faith cannot be relegated to the four walls of a church for an hour or two on Sunday morning. As stated in the Book of James, “Faith without works is dead.” Faith in Jesus Christ is expected to affect every aspect of a believer's life, including how he behaves “in the marketplace.” If it does not, one has to wonder about his faith. That is not to imply that a Christian should be ...Reference1. Graner J. Physicians and patient spirituality [Letter]. Ann Intern Med. 2000;133:748. [PMID: 11074919] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Gerald P. Bodey, MDAffiliations: The Woodlands, TX 77381 (Bodey) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPhysicians and Patient Spirituality John Graner Physicians and Patient Spirituality John Graner Physicians and Patient Spirituality Susan B. LeGrand Physicians and Patient Spirituality John Graner Physicians and Patient Spirituality John Graner Physicians and Patient Spirituality Susan B. LeGrand Metrics Cited byPhysicians and Patient SpiritualitySusan B. LeGrand, MD 7 August 2001Volume 135, Issue 3Page: 220KeywordsSports ePublished: 7 August 2001 Issue Published: 7 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
DNA Repair Pathway Profiling and Microsatellite Instability in Colorectal Cancer
Authors: Jinsheng Yu, Mary A. Mallon, Wanghai Zhang, Robert R. Freimuth, Sharon Marsh, Mark A. Watson, Paul J. Goodfellow, Howard L. McLeod
Journal: Clinical Cancer Research (2006)

Abstract Background: The ability to maintain DNA integrity is a critical cellular function. DNA repair is conducted by distinct pathways of genes, many of which are thought to be altered in colorectal cancer. However, there has been little characterization of these pathways in colorectal cancer. Method: By using the TaqMan real-time quantitative PCR, RNA expression profiling of 20 DNA repair pathway genes was done in matched tumor and normal tissues from 52 patients with Dukes' C colorectal cancer. Results: The relative mRNA expression level across the 20 DNA repair pathway genes varied considerably, and the individual variability was also quite large, with an 85.4 median fold change in the tumor tissue genes and a 127.2 median fold change in the normal tissue genes. Tumor-normal differential expression was found in 13 of 20 DNA repair pathway genes (only XPA had a lower RNA level in the tumor samples; the other 12 genes had significantly higher tumor levels, all P &amp;lt; 0.01). Coordinated expression of ERCC6, HMG1, MSH2, and POLB (RS ≥ 0.60) was observed in the tumor tissues (all P &amp;lt; 0.001). Apoptosis index was not correlated with expression of the 20 DNA repair pathway genes. MLH1 and XRCC1 RNA expression was correlated with microsatellite instability status (P = 0.045 and 0.020, respectively). An inverse correlation was found between tumor MLH1 RNA expression and MLH1 DNA methylation (P = 0.003). Conclusion: Our study provides an initial characterization of the DNA repair pathways for understanding the cellular DNA damage/repair system in human colorectal cancer.
Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3
Authors: Bercin K. Cenik, Ankit Garg, John R. McAnally, John M. Shelton, James A. Richardson, Rhonda Bassel-Duby, Eric N. Olson, Ning Liu
Journal: Journal of Clinical Investigation (2015)

Maintenance of skeletal muscle structure and function requires a precise stoichiometry of sarcomeric proteins for proper assembly of the contractile apparatus. Absence of components of the sarcomeric thin filaments causes nemaline myopathy, a lethal congenital muscle disorder associated with aberrant myofiber structure and contractility. Previously, we reported that deficiency of the kelch-like family member 40 (KLHL40) in mice results in nemaline myopathy and destabilization of leiomodin-3 (LMOD3). LMOD3 belongs to a family of tropomodulin-related proteins that promote actin nucleation. Here, we show that deficiency of LMOD3 in mice causes nemaline myopathy. In skeletal muscle, transcription of Lmod3 was controlled by the transcription factors SRF and MEF2. Myocardin-related transcription factors (MRTFs), which function as SRF coactivators, serve as sensors of actin polymerization and are sequestered in the cytoplasm by actin monomers. Conversely, conditions that favor actin polymerization de-repress MRTFs and activate SRF-dependent genes. We demonstrated that the actin nucleator LMOD3, together with its stabilizing partner KLHL40, enhances MRTF-SRF activity. In turn, SRF cooperated with MEF2 to sustain the expression of LMOD3 and other components of the contractile apparatus, thereby establishing a regulatory circuit to maintain skeletal muscle function. These findings provide insight into the molecular basis of the sarcomere assembly and muscle dysfunction associated with nemaline myopathy.
PREPARATION OF LACTIC ACID MILK MIXTURES FOR INFANT FEEDING
Authors: McKIM MARRIOTT
Journal: JAMA (1927)

Whole undiluted lactic acid milk, enriched with commercial corn syrup, was originally introduced as a satisfactory food mixture for athreptic infants.<sup>1</sup>A further experience, however, has led to the conclusion that such formulas are excellently adapted to the routine feeding of normal infants.<sup>2</sup>The type of feeding described does not lead to gastro-intestinal disturbances, even in young and undernourished infants. The composition of the formula does not have to be changed during a large part of the first year, the infant merely being offered increasingly larger amounts of the same food mixture as he becomes older. The caloric value is high (from 25 to 30 calories an ounce), and because of this fact a smaller number of feedings during the day is necessary, and malnutrition due to underfeeding does not occur. An experience of eight years with the feeding of several hundred infants in welfare clinics in practice
Danish Multicenter Randomized Study of Invasive Versus Conservative Treatment in Patients With Inducible Ischemia After Thrombolysis in Acute Myocardial Infarction (DANAMI)
Authors: Jan K. Madsen, Peer Grande, Kari Saunamäki, Per Thayssen, Eli Kassis, Ulrik Eriksen, Klaus Rasmussen, Stig Haunsø, Torsten T. Nielsen, Torben Haghfelt, Per Fritz-Hansen, Erik Hjelms, Peter K. Paulsen, Poul Alstrup, Henrik Arendrup, Uffe Niebuhr-Jørgensen, Lars I. Andersen
Journal: Circulation (1997)

Background The aim of the DANish trial in Acute Myocardial Infarction (DANAMI) study was to compare an invasive strategy of percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass grafting (CABG) with a conservative strategy in patients with inducible myocardial ischemia who received thrombolytic treatment for a first acute myocardial infarction (AMI). Methods and Results Of the 503 patients randomized to an invasive strategy, PTCA was performed in 266 (52.9%) and CABG in 147 (29.2%) from 2 to 10 weeks after the AMI. Of the 505 patients in the conservative treatment group, only 8 (1.6%) had been revascularized 2 months after the AMI. The patients were followed up from 1 to 4.5 years. The primary end points were mortality, reinfarction, and admission with unstable angina. At 2.4 years’ follow-up (median), mortality was 3.6% in the invasive treatment group and 4.4% in the conservative treatment group (not significant). Invasive treatment was associated with a lower incidence of AMI (5.6% versus 10.5%; P =.0038) and a lower incidence of admission for unstable angina (17.9% versus 29.5%; P &lt;.00001). The percentages of patients with a primary end point were 15.4% and 29.5% at 1 year, 23.5% and 36.6% at 2 years, and 31.7% versus 44.0% at 4 years ( P =&lt;.00001) in the invasive and conservative treatment groups, respectively. At 12 months, stable angina pectoris was present in 21% of patients in the invasive treatment group and 43% in the conservative treatment group. Conclusions Invasive treatment in post-AMI patients with inducible ischemia results in a reduction in the incidence of reinfarction, fewer admissions due to unstable angina, and lower prevalence of stable angina. We conclude that patients with inducible ischemia before discharge who have received treatment with thrombolytic drugs for their first AMI should be referred to coronary arteriography and revascularized accordingly.
A Novel PITX2 Mutation and a Polymorphism in a 5-Generation Family with Axenfeld–Rieger Anomaly and Coexisting Fuchs’ Endothelial Dystrophy
Authors: Christoph Kniestedt, Malgorzata Taralczak, Michael A. Thiel, Joerg Stuermer, Alessandra Baumer, Balder P. Gloor
Journal: Ophthalmology (2006)
Expression of Insulinlike Growth Factor (IGF) and IGF-Binding Protein Genes in Human Lung Tumor Cell Lines
Authors: J. G. Reeve, A. Brinkman, S. Hughes, J. Mitchell, J. Schwander, N. M. Bleehen
Journal: JNCI Journal of the National Cancer Institute (1992)

Background : The presence of multiple, low-molecular-weight, insulinlike growth factor (IGF)-binding proteins in lung tumor cell-conditioned medium and lung cancer patient serum has been recently reported. Purpose : To begin to elucidate the genetic basis for these observations, the present study examines the expression by lung tumor cell lines of three IGF-binding protein genes, namely, IGFBP-1, IGFBP-2, and IGFBP-3. Since IGF-binding proteins are thought to modulate the biologic action of the IGFs, the relationship between the expression of IGF-binding protein genes and the genes encoding IGF-I and IGF-II also has been investigated. Methods : Gene expression was studied in four small-cell lung cancer (SCLC) and three non—small-cell lung cancer (NSCLC) cell lines using Northern blot analysis and reverse transcriptase polymerase chain reaction (RT-PCR) for IGFBP-1. Results : IGFBP-1 gene expression was detected by Northern blot analysis in one NSCLC cell line only. However, RT-PCR revealed that the IGFBP-1 gene was expressed in all four SCLC cell lines and in two of the three NSCLC lines. Northern blot analysis of IGFBP-2 gene expression demonstrated that all lung tumor cell lines expressed this gene. A low level of IGFBP-3 gene expression was detected in one SCLC cell line and in all three NSCLC cell lines. All lung tumor cell lines expressed the IGF-II gene as determined by Northern blot analysis. In marked contrast, none of the lines showed evidence of IGF-I gene expression using this method. However, RT-PCR revealed a low level of IGF-I gene expression in one SCLC and one NSCLC cell line only. Conclusions : These observations indicate 1) that IGF-binding proteins secreted by lung tumors are encoded by at least three different genes; 2) that there may be a close association between IGF-II and IGFBP-2 gene expression, such that, where there is production of IGF-II, IGFBP-2 is the principal BP; and 3) that the IGF-II gene is more widely expressed than the IGF-I gene in human lung tumor cell lines. [J Natl Cancer Institute 84: 628–634, 1992]
GENDER DIFFERENCES IN LONG-TERM CLINICAL OUTCOME AFTER PERCUTANEOUS REVASCULARISATION OF MULTIVESSEL CORONARY ARTERY DISEASE: INSIGHTS FROM AUTAX REGISTRY
Authors: Mariann Gyongyosi, Rosa Badr-Eslam, Susanne Winkler, Noemi Nyolczas, Irene Lang, Günter Christ, Gerhard Kreiner, Dietmar Glogar
Journal: Journal of the American College of Cardiology (2010)
Nocturnal Home Oximetry in Detecting the Sleep Apnea-Hypopnea Syndrome and in Working Up Hypersomnolence
Authors: Alejandro D. Chediak
Journal: Annals of Internal Medicine (1994)

Letters1 March 1994Nocturnal Home Oximetry in Detecting the Sleep Apnea-Hypopnea Syndrome and in Working Up HypersomnolenceNeil T. Feldman, MD and Harpreet Singh, MDNeil T. Feldman, MDSt. Petersburg Sleep Disorders Center; St. Petersburg, FL 33707Search for more papers by this author and Harpreet Singh, MDSt. Petersburg Sleep Disorders Center; St. Petersburg, FL 33707Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-5-199403010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Series and colleagues [1] concluded that nocturnal home oximetry screening in patients suspected to have the obstructive sleep apnea–hypopnea syndrome would decrease the number of patients who required complete polysomnographic monitoring. They suggested, however, that because of its low specificity and consequent low positive predictive value, positive home oximetry must be followed by complete polysomnographic monitoring. They studied 240 outpatients referred because of reported sleep disturbances or daytime hypersomnia and confirmed the syndrome in 110. The diagnosis and follow-up of the remaining 130 patients were not defined by the study.Patients not found to have the syndrome ...REFERENCE1. Series F, Marc I, Cormier Y, LaForge J. Utility of nocturnal home oximetry for case finding in patients with suspected sleep apnea hypopnea syndrome. Ann Intern Med. 1993; 119:449-53. Google Scholar Author, Article, and Disclosure InformationAffiliations: St. Petersburg Sleep Disorders Center; St. Petersburg, FL 33707 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUse of Ambulatory Overnight Oximetry to Investigate Sleep Apnea in a General Internal Medicine PracticeAlternativas a la polisomnografía convencional en el diagnóstico y tratamiento del síndrome de apneas durante el sueño 1 March 1994Volume 120, Issue 5Page: 439-440KeywordsCentral nervous systemMovement disordersNarcolepsyOutpatientsPolysomnographyPositive predictive valueSleepSleep apneaSleep deprivationSpecificity Issue Published: 1 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A COMPARISON OF PSYCHOTHERAPEUTIC RELATIONSHIPS BETWEEN PHYSICIANS AND SCHIZOPHRENIC PATIENTS WHEN INSULIN IS COMBINED WITH PSYCHOTHERAPY AND WHEN PSYCHOTHERAPY IS USED ALONE
Authors: JOHN C. WHITEHORN, BARBARA J. BETZ
Journal: American Journal of Psychiatry (1957)

Psychotherapeutic relationships between 18 physicians and 109 schizophrenic patients were compared and contrasted when insulin was combined with psychotherapy and when psychotherapy was used alone, in relation to the outcome of treatment. The patients are divided into an A group (those whose physicians achieved an improvement rate of 70% or higher) and a B group (those whose physicians achieved an improvement rate of less than 70%). Our findings indicate that: 1. Insulin combined with psychotherapy is associated with a numerical increase in improvement only in the B patients (from 34% to 82%). A patients show no numerical gain (the rate remaining at 82%). 2. The higher numerical rate of improvement in the B group when insulin is combined with psychotherapy does not carry with it an increase in quality of improvement. Only one B patient reached the highest grade of improvement and in this case insulin was not used. Nor are qualitative gains associated with the use of insulin in the A patients. 3. The A physicians, with or without insulin, achieve the best qualitative results (12 of 13 patients at the highest grade of improvement). 4. The empirical findings of our earlier study of 14 physicians and 100 schizophrenic patients are confirmed, in that favorable outcome was again found most likely when the physician's Personal Diagnostic Formulation shows some grasp of the personal meaning of the patient's behavior; when he aims at assisting the patient in modifications of personal adjustment patterns and a more constructive use of assets rather than focusing on psychopathology; when, in his day-by-day tactics he participates with the patient in an active personal way; and when a trusting, confidential relationship develops between physician and patient. These styles of transaction were again found to be more characteristic of the A than the B physicians. 5. B physicians more frequently use the tactical pattern of active personal participation when insulin is combined with psychotherapy (54%) than when psychotherapy is used alone (9%). B patients who receive insulin are thus more frequently the recipients of one of the more effective psychotherapeutic patterns in contacts with their physicians than those treated by the same physicians without insulin, and this may account in considerable part for their greater numerical improvement. 6. The tactical pattern of active, personal participation which is particularly highly associated with good numerical and qualitative levels of improvement (94% over-all improvement in this series, 85% in the earlier study), was not used in the majority of their cases by either the A or B physicians. It is suggested that this mode of therapeutic participation with schizophrenic patients merits more extensive trial.
FAMILIAL RENAL TUBULAR ACIDOSIS REVISITED
Authors: RUSSELL E. RANDALL
Journal: Annals of Internal Medicine (1967)

Letters and Comments1 May 1967FAMILIAL RENAL TUBULAR ACIDOSIS REVISITEDRUSSELL E. RANDALL JR., M.D.RUSSELL E. RANDALL JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1024_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The family with renal tubular acidosis reported in 1961 (1) has now been observed for 6 years.Two new cases (Members IV-8 and IV-10) have been documented in the fourth generation (Figure 1), further supporting the concept that the disorder is governed by an autosomal dominant gene. Both have hyperchloremic acidosis, a persistently alkaline urine, and minimal nephrocalcinosis. Member IV-8 at 1 month of age was unable to elaborate a urine more acid than pH 6.5 despite a serum bicarbonate of 11 mmoles/liter during ammonium chloride loading. Nephrocalcinosis was detected in this child at age 3 when...References1. RANDALLTARGGART REWH: Familial renal tubular acidosis. Ann. Intern. Med. 54: 1108, 1961. LinkGoogle Scholar2. LIGHTWOODPAYNEBLACK RWWJA: Infantile renal acidosis. Pediatrics 12: 628, 1953. MedlineGoogle Scholar3. BUCHANANKOMROWER EWGM: The prognosis of idiopathic renal acidosis in infancy with observations on urine acidification and ammonia production in children. Arch. Dis. Child. 33: 532, 1958. CrossrefMedlineGoogle Scholar4. HUTHWEBSTERELKINTON EJGDJR: The renal excretion of hydrogen ion in renal tubular acidosis. III. An attempt to detect latent cases in a family; comments on nosology, genetics and etiology of the primary disease. Amer. J. Med. 29: 586, 1960. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Renal Disease Department of Medicine Medical College of Virginia Richmond, Va. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRenal Tubular DisordersHypokalemic paralyses: A review of the etiologies, pathophysiology, presentation, and therapyPathogenesis of UrolithiasisRenal Tubular Acidosis10 Metabolic acidosis in the newborn periodRenal tubular acidosis in childhoodPrimary Renal Tubular Acidosis Recognized and Treated at Three Days of AgeStatus and Prospects of Research in Hereditary DeafnessRenal acidosisIncomplete renal tubular acidosisFamilial Renal Tubular AcidosisVARDAMAN M. BUCKALEW JR., M.D. 1 May 1967Volume 66, Issue 5Page: 1024-1025KeywordsAutosomal dominant diseasesBicarbonatesChloridesUrine Issue Published: 1 May 1967 PDF DownloadLoading ...
Redeclared War on Illegal Drugs: Most Agree With Intent, but How?
Authors: Charles Marwick
Journal: JAMA (1989)

THE REDECLARED WAR against illegal drugs now is 1 month old (<i>JAMA</i>. 1989;262:1574) and much of the fighting at this point is infighting by those—in and out of government—on the same side. William Bennett, PhD, the Bush Administration's point man, has laid out a strategy that calls for spending approximately $7.9 billion on anti-drug-abuse programs, including treatment, education, law enforcement, and interdiction. This would be a 118% increase in current levels of federal spending. For example, there would be a 53% increase—from $604 million to $925 million—for treatment programs. There would be a 25% increase—from $943 million to $1.2 billion—for education and prevention. And there would be increases for prison construction (the goal is 95 000 more federal prison beds, including some so-called boot camp facilities) — from $734 million to $1.6 billion — and for state and local law enforcement agencies (although matching funds would be required)—from $150 million
Treatment of Hyperthyroidism with Thiouracil
Authors: A. M. Nussey
Journal: BMJ (1944)

Until recently partial thyroidectomy was the treatment of choice for thyrotoxicosis.X rays and radium had their advocates, and some continued to pin their faith to iodine, either alone or in combination with various sedatives.It is true that in quite a number of mild cases of thyrotoxicosis the disease would abate spontaneously; but only too often, especially in severe instances, the patient treated medically for too long would become a physical, sometimes a mental, wreck, or fall an easy prey to intercurrent infection.The advent of thiourea, and especially of thiouracil, bids fair to alter the position radically.These preparations may represent only a milestone in the approach to a problem the real key to which may be a substance acting through the pituitary ; but at present, to say the least, they offer a serious challenge to the hitherto undisputed sway of surgery in the treatment of hyperthyroidism.rhe use of thiourea and thiouracil in thyrotoxicosis is an example of how seemingly unrelated research may sometimes, almost by accident, be turned to advantage in treatment of disease.This.research began when the Mackenzies and McCollum (1941), working on the effects of sulphaguanidine in rats, discovered that it had the property of inducing a hypothyroid state and enlargement of the thyroid gland in the experimental animals.At about the same time similar results were obtained by Richter andClisby (1941, 1942), who used phenyl thiourea, and by Kennedy (1942), who used allyl thiourea which he isolated from rape seed.Later the