tbuckley/cabot-search huggingface dataset:
Abstract 4589: Changes in proteomic profiles with age in male rats using the iTRAQ approach
Authors: Arunangshu Das, John Richie, James Bortner, Cesar Aliaga, Anne Stanley, Bruce A. Stanley, Karam El-Bayoumy
Journal: Cancer Research (2010)

Abstract Aging is an important risk factor for many diseases including prostate cancer (PC). Enhanced risk for disease may, in part, be due to aging-related changes in the proteome. Thus, a better knowledge of the changes in protein levels occurring with age would help in the early detection of the disease, as well as in monitoring chemopreventive intervention. In the present study we used male F344 rats, a commonly used aging and PC model, and compared protein levels in the blood plasma of young (4 months), mature (12 months), old (18 months) and very old (24 months) rats by a proteomic approach known as isobaric Tag for Relative and Absolute Quantitation (iTRAQ). In this multi-plex non-gel based technique samples can be simultaneously labeled with isobaric tagging reagents for quantitation and identification by mass spectrometry. Plasma samples were pooled from three animals and 50 μg of protein from each group was labeled for a 4-plex iTRAQ analysis. A total of seventy nine proteins were identified, thirty one with &amp;gt;99% confidence. Among those, the levels of thirteen proteins were changed significantly (p&amp;lt;0.05) with age and five of which with &amp;gt;99% confidence including serotransferrin, hemopexin, fetuin-A, fetuin-B and α-1-acid glycoprotein. Both age-specific and growth-development related changes were observed throughout the life span with maximum changes (either increases or decreases) being observed at 18 months. The results of this study show that age indeed can influence the expression profile of plasma proteins. The relationship of these proteins to PC is currently being investigated by analyzing their levels in different lobes of the prostate gland. Supported in part by R01 CA 127729-01 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4589.
Abstract 10208: Nardilysin Regulates Circulatory Dynamics Through Modulating Sympathetic Nerve Innervation
Authors: Mikiko T Ohno, Yoshinori Hiraoka, Tatsuhiko Matsuoka, Kiyoto Nishi, Sayaka Saijo, Takeshi Kimura, Eiichiro Nishi
Journal: Circulation (2011)
NSCLC Drug Targets Acquire New Visibility
Authors: M. J. Friedrich
Journal: JNCI Journal of the National Cancer Institute (2011)

F or researchers studying drug targets in non – small-cell lung cancer (NSCLC), 2010 was a very good year. The National Comprehensive Cancer Network recommended, for the fi rst time, that oncologists test their NSCLC patients for EGFR mutations and treat those testing positive with erlotinib (Tarceva). In June, the American Society of Clinical Oncology annual meeting featured a phase I/II trial of a newer targeted NSCLC drug, crizotinib, which the New England Journal of Medicine later published. And in October, at the annual meeting of the European Society for Medical Oncology (ESMO), sessions focused on major trials with erlotinib and gefi tinib (Iressa), both targeted at EGFR mutations, as well as newer agents targeting MET, HER2, and other genes with mutated versions that appear to drive the development of NSCLC. The reports allowed researchers to savor progress and pronounce hope for targeted therapies in NSCLC, a cancer that has not responded markedly to traditional chemotherapies. “At this point we’ve found driver mutations in over half of lung cancer patients,” said Mark Kris, M.D ., of Memorial Sloan – Kettering Cancer Center in New York. “Even for those in whom we don’t fi nd a driver mutation, at least we know not to subject our patients to drugs that don’t work.”
LATENT DIPHTHERIA.A PUBLIC HEALTH PROBLEM.
Authors: MYER SOLIS-COHEN
Journal: JAMA (1907)

<h3>CAUSES OF DIPHTHERIA PREVALENCE.</h3> From the public health viewpoint, diseases are studied in order to prevent their spread. Effective prophylactic measures, based on scientific observations, have caused some infectious diseases to disappear from civilized communities, while others have become comparatively rare. Yet, despite the ever-increasing knowledge as to its bacteriology and methods of propagation, diphtheria still remains a fairly common affection. Why is this? One reason is that only the well-marked cases are isolated and placarded, while persons suffering from the milder forms of diphtheria are permitted to walk the streets, attend school and frequent public places. Another unguarded avenue of contagion is kept open through the false sense of security given by the rules now in vogue as to disinfection. Fomites, which, as shown by Chapin,† Hill, Weichard and Welch, only rarely contain the germs, are required to be disinfected, while no attention is paid to the virulent bacilli
Gestational diabetes: is a higher cesarean section rate inevitable?
Authors: R G Moses, S J Knights, E M Lucas, M Moses, K G Russell, K J Coleman, W S Davis
Journal: Diabetes Care (2000)

To determine the rate of and indication for cesarean section for women with gestational diabetes mellitus (GDM) compared with glucose-tolerant women.From a consecutive series of women with GDM seen over a 9-year period for medical management, women who had had a cesarean section were identified and the reason for the section determined from a review of the medical record. A control group of women who had had a section were obtained from an existing database of glucose-tolerant women.The section rate for women with GDM was higher at 19.8% than the 15.6% for glucose-tolerant women. However, after adjustment for age and parity, no significant differences were found. There were also no differences found for the primary indication for section.In our health area of New South Wales, Australia, women with GDM do not have a higher section rate compared with glucose-tolerant women. Concerns about the diagnosis of GDM leading to an increased rate of obstetric intervention should not be generalized.
A Universal Decision Support System. Addressing the Decision-Making Needs of Patients, Families, and Clinicians in the Setting of Critical Illness
Authors: Christopher E. Cox, Douglas B. White, Amy P. Abernethy
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

Section:ChooseTop of pageAbstract <<The Clinical Tasks of Dec...There Is a Significant Qu...Decision Aids Can Improve...What Are the Limitations ...A "Universal" Decision Su...Defining Developmental Ch...ConclusionsReferencesCITING ARTICLES
The Fixed Eruption
Authors: Robert G. Carney
Journal: JAMA (1961)

This is an extremely comprehensive review of a fascinating subject, the fixed drug eruption. It should provide a fine reference for dermatologists and others interested in fixed drug eruptions and in drug eruptions in general. The author's concept of the fixed drug eruption is more comprehensive than the concepts many others hold, but, aside from some confusion in nomenclature, this may well make the monograph more useful. The list of drugs included is unusually complete.
VIOSTEROL OF HIGH POTENCY IN SEASONAL HAY FEVER AND RELATED CONDITIONS
Authors: B. Z. RAPPAPORT
Journal: JAMA (1933)

Until recently, the literature on the blood calcium and the therapeutic value of calcium in allergic conditions has been replete with contradictions. It is unnecessary in this work to do more than summarize various views. Briefly, there are those who believe that a calcium deficiency is present in allergy, and that calcium is indicated as an adjunct in treatment, and those who find no such deficiency and deny the value of calcium as a therapeutic agent in allergic conditions. Almost all the work since 1928 based on blood chemistry studies made since the development of the Kramer-Tisdall technic for calcium determination supports the latter point of view. Among the more recent workers who also review the literature to date are Cohen and Rudolph<sup>1</sup>and Ramirez.<sup>2</sup>In studies on a large number of various types of allergic conditions these workers found no calcium deficiency and no improvement or only
Abstract 1389: Insights into the invasiveness of triple-negative breast cancer from genome-wide profiling of AP-1
Authors: Chunyan Zhao, Yichun Qiao, Karin Dahlman-Wright
Journal: Cancer Research (2014)

Abstract Triple-negative breast cancer (TNBC) is an aggressive clinical phenotype, and accounts for 15% to 20% of all breast cancers. The molecular determinants of malignant cell behaviors in TNBC remain largely unknown. We show that the AP-1 transcription factor component Fra-1 is overexpressed in basal-like breast tumors, often referred to as TNBCs, and that its expression level has high prognostic significance. Depletion of Fra-1 or its heterodimeric partner c-Jun inhibits the proliferative and invasive phenotypes of TNBC cells in vitro. Furthermore, knockdown of Fra-1 or c-Jun also reduces cellular invasion in vivo in a zebrafish xenograft model. Exploring the AP-1 cistrome and the AP-1-regulated transcriptome, we provide insights into the transcriptional regulatory networks of AP-1 in TNBC cells. We identify direct targets of the Fra-1/c-Jun heterodimer involved in cell proliferation, cell adhesion, and cell-cell contact. Importantly, we show that AP-1 represses E-cadherin expression by transcriptional upregulation of ZEB2, thereby stimulating cell invasion. This work sheds light on mechanisms and pathways by which TNBCs acquire invasiveness and proliferative propensity. Note: This abstract was not presented at the meeting. Citation Format: Chunyan Zhao, Yichun Qiao, Karin Dahlman-Wright. Insights into the invasiveness of triple-negative breast cancer from genome-wide profiling of AP-1. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1389. doi:10.1158/1538-7445.AM2014-1389
Potentiation of Tolbutamide by Dicumarol
Authors: HERBERT S. SISE
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 August 1967Potentiation of Tolbutamide by DicumarolHERBERT S. SISE, M.D., F.A.C.P.HERBERT S. SISE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-460 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe "Drug Explosion" has bred a litter of dilemmas. Simpler was life for the patient of yesteryear who was given a sugarcoated pill. Nowadays he emerges from the hospital, doctor's office, or clinic with pockets bulging with drugs. Some of these are drugs that though innocuous in solo can be lethal in concert. The most recent case of such drug interaction, demonstrated by Kristensen and Hansen (1), is a potentiation of the effect of tolbutamide by dicumarol.Prompted by the observation of a hypoglycemic episode in a diabetic patient recently started on dicumarol, these investigators studied four diabetic patients who...References1. KRISTENSENHANSEN MJM: Potentiation of the tolbutamide effect by dicoumarol. Diabetes 16: 211, 1967. CrossrefMedlineGoogle Scholar2. DAYTONTARCINCHENKINWEINER PGYTM: The influence of barbiturates on coumarin plasma levels and prothrombin response. J. Clin. Invest. 40: 1797, 1961. CrossrefMedlineGoogle Scholar3. AGGELERO'REILLYLEONGKOWITZ PMRALPE: Potentiation of anticoagulant effect of warfarin by phenylbutazone. New Eng. J. Med. 276: 496, 1967. CrossrefMedlineGoogle Scholar4. D'ANGELOLEGRESLEY GLP: Severe hypoprothrombinemia after propylthiouracil therapy. Canad. Med. Ass. J. 81: 479, 1959. MedlineGoogle Scholar5. OLIVERROBERTSHAYESPANTRIDGESUZMANBERSOHN MFSDDJFMMI: Effect of atromid and ethy chlorophenoxyisobutyrate on anticoagulant requirements. Lancet 1: 143, 1963. CrossrefMedlineGoogle Scholar6. OWENSNEELYOWEN JCWBWR: Effect of sodium dextrothyroxine in patients receiving anticoagulants. New Eng. J. Med. 266: 76, 1962. CrossrefMedlineGoogle Scholar7. CULLENCATALANO SIPM: Griseofulvinwarfarin antagonism. JAMA 199: 582, 1967. CrossrefMedlineGoogle Scholar8. HANSENKRISTENSENSKOVSTEDCHRISTENSEN JMMLLK: Dicoumarol-induced diphenylhydantoin intoxication. Lancet 2: 265, 1966. CrossrefMedlineGoogle Scholar9. CHRISTENSENHANSENKRISTENSEN LKJMM: Sulfaphenazole-induced hypoglycemic attacks in tolbutamide-treated diabetics. Lancet 2: 1298, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Circulation Laboratory Boston City Hospital Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHypoglycemia in the elderly diabeticInteractions of Oral Coumarin Anticoagulants with other Drugs 1 August 1967Volume 67, Issue 2Page: 460-461KeywordsDrug interactionsDrugsHospitalsHypoglycemics Issue Published: 1 August 1967 PDF DownloadLoading ...
Topical photodynamic therapy in clinical dermatology
Authors: T. Kormeili, P.S. Yamauchi, N.J. Lowe
Journal: British Journal of Dermatology (2004)

The growing incidence of cutaneous malignancies each year necessitates the development of new and more effective methods for both the diagnosis and the treatment of cancerous lesions, while assuring better cosmetic results and improving patient satisfaction. With that in mind, the use of topical photodynamic therapy (PDT) has been explored in the treatment as well as the diagnosis of various cutaneous malignancies. Using the intrinsic cellular haem biosynthetic pathway and principles of photoillumination, topical PDT carries the goal of selectively targeting abnormal cells, while preserving the normal surrounding structures. This paper will discuss the various applications and data on the use of topical PDT in dermatology.
Intraoperative Cholangiography and Risk of Common Bile Duct Injury During Cholecystectomy
Authors: David R. Flum, E. Patchen Dellinger, Allen Cheadle, Leighton Chan, Thomas Koepsell
Journal: JAMA (2003)

Intraoperative cholangiography (IOC) may decrease the risk of common bile duct (CBD) injury during cholecystectomy by helping to avoid misidentification of the CBD.To characterize the relationship of IOC use and CBD injury while controlling for patient and surgeon characteristics.Retrospective nationwide cohort analysis of Medicare patients undergoing cholecystectomy from January 1, 1992, to December 31, 1999. Patients were identified using Current Procedural Terminology codes from the Medicare Part B depository. Common bile duct injury was defined by a second surgical procedure to repair the CBD injury within 1 year of cholecystectomy. Surgeon demographic features were obtained from matching the Medicare Part B data to the American Medical Association Physician Masterfile database.Frequency of CBD injury in patients who did and did not have IOC performed during cholecystectomy, controlling for patient-level (age, sex, race, and case complexity) and surgeon-level (surgeon's age, sex, race, year of surgical procedure, case order, percentage of IOC use in prior surgical procedures, years in medical practice, board certification, and specialization) factors.The database search identified 1 570 361 cholecystectomies and 7911 CBD injuries (0.5%). Common bile duct injury was found in 2380 (0.39%) of 613 706 patients undergoing cholecystectomy with IOC and in 5531 (0.58%) of 956 655 patients undergoing cholecystectomy without IOC (unadjusted relative risk, 1.49; 95% confidence interval, 1.42-1.57). After controlling for patient-level factors and surgeon-level factors, the risk of injury was increased when IOC was not used (adjusted relative risk, 1.71; 95% confidence interval, 1.38-2.28). While surgeons performing IOCs routinely had a lower rate of CBD injuries than those who did not, this difference disappeared when IOC was not used.In this study of Medicare patients undergoing cholecystectomy in the 1990s, the risk of CBD injury was significantly higher when IOC was not used. Although IOCs may not prevent all CBD injuries, this study suggests that the routine use of IOC may decrease the rate of CBD injury.
Prolactin in Clinical Practice
Authors: Maire T. Buckman
Journal: JAMA (1976)

ISOLATION of human prolactin and the development of highly sensitive and specific radioimmunoassays have allowed precise quantitation of serum prolactin concentrations in humans. Although changes in prolactin secretion have been described in a variety of physiologic and pathologic conditions, our understanding of the physiologic effects of prolactin is scant. Only the obligatory role of prolactin in lactation has been established. Since random serum prolactin concentrations are only slightly lower in normal men than in normal women, prolactin may have physiologic effects unrelated to lactation. The kidney<sup>1</sup>and the adrenal<sup>2</sup>have been suggested as target organs for prolactin action. Further investigative efforts are required to explore the implications of these and other possible physiologic effects of prolactin in man. <h3>Regulation of Prolactin Secretion</h3><h3>Prolactin-Inhibitory Factor (PIF).—</h3> Prolactin secretion is primarily under tonic hypothalamic inhibitory control (Figure). Although a specific PIF has yet to be isolated, the importance of this
Australia Antigen Associated Hepatitis: Radioimmunoassay in Mother and Infant
Authors: Kenneth P. Lyons
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Neonatal hepatitis has been vigorously investigated, but to date the results have been confusing and contradictory.<sup>1-6</sup>The question of transplacental transmission is still unsettled.<sup>2</sup>Stokes et al transmitted hepatitis to human volunteers from the serum of a 9-month-old infant who seven months earlier had had hepatitis.<sup>3</sup>Blood from the infant's mother, although she had no history or hepatitis, was also shown to be capable of transmitting hepatitis to volunteers. The recent discovery of Australia antigen, which appears to be associated with serum hepatitis, provides a valuable tool for another investigation of this problem. Two studies are reported in which this had been attempted.<sup>7,8</sup>In the first report, although Australia antigen was still present in the mother's serum at time of delivery, 17 months after hepatitis, cord blood failed to show evidence of antigen by the Ouchterlony method. In the second study there were
1085-193 The effect of losartan versus atenolol on hemostasis and fibrinolysis in hypertensive patients with left ventricular hypertrophy: A LIFE substudy
Authors: Kurt O Boman, Michael Hecht Olsen, Kristian Wachtell, Mona Olofsson, Hans Ibsen, Harriet Dige-Petersen, Torbjörn K Nilsson
Journal: Journal of the American College of Cardiology (2004)
Perceiving Need for Lifestyle Counseling
Authors: Sanna M. Salmela, Kati A. Vähäsarja, Jari J. Villberg, Mauno J. Vanhala, Timo E. Saaristo, Jaana Lindström, Heikki H. Oksa, Eeva A.-L. Korpi-Hyövälti, Leena Moilanen, Sirkka Keinänen-Kiukaanniemi, Marita E. Poskiparta
Journal: Diabetes Care (2011)

To investigate the proportion of individuals at high risk of type 2 diabetes who perceive the need for lifestyle counseling, factors associated with this perception, and whether the perceived need is associated with subsequent attendance in lifestyle intervention.
Three Potential Susceptibility Loci Shown by a Genome-Wide Scan for Regions Influencing the Age at Onset of Mania
Authors: Stephen V. Faraone, Stephen J. Glatt, Jessica Su, Ming T. Tsuang
Journal: American Journal of Psychiatry (2004)

The age at onset of bipolar disorder is associated with clinical features of the illness, including duration, severity, and pattern of comorbidity with other disorders. Age at onset is familial and heritable, and it correlates inversely with the prevalence of bipolar disorder among relatives. Because age at onset may have utility in resolving the complexity and heterogeneity of the disorder, the authors sought to identify chromosomal loci that harbor the genes influencing this trait.A genome scan of 539 genotyped people in 97 families ascertained for the NIMH Bipolar Disorder Genetics Initiative was performed by using multipoint variance-components linkage analysis.The age at onset of mania was significantly heritable in these families. Three chromosomal regions yielded nonsignificant but suggestive multipoint lod scores greater than 2.5, with the strongest evidence observed at markers D12S1292, GATA31B, and GATA50C, on chromosomes 12p, 14q, and 15q, respectively.Although firm conclusions await an independent replication, these results suggest that three regions of the genome may contain genes influencing the age at onset of mania in bipolar disorder. To the authors' knowledge, these regions have not been implicated previously in risk for the disorder, suggesting that separate sets of genes influence disease susceptibility and the age at which it appears.
Utility of Different Lipid Measures to Predict Coronary Heart Disease
Authors: Justo Sierra-Johnson, Abel Romero-Corral, Francisco Lopez-Jimenez
Journal: JAMA (2008)

To the Editor: Dr Ingelsson and colleagues1 conclude that their data do not support measurement of apo B or apo A-I in clinical practice when total cholesterol and HDL-C measurements are available. We believe their conclusions reach further than their data support.
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant
Authors: Laurent O. Mosnier, Antonella Zampolli, Edward J. Kerschen, Reto A. Schuepbach, Yajnavalka Banerjee, José A. Fernández, Xia V. Yang, Matthias Riewald, Hartmut Weiler, Zaverio M. Ruggeri, John H. Griffin
Journal: Blood (2009)
The younger disabled unit at Fazakerley Hospital.
Authors: T B Benson, E Williams
Journal: BMJ (1979)

The activities of a new younger disabled unit reflect the changing pattern of care now being provided for severely physically disabled young people. A co-ordinated team approach to their rehabilitation has enabled all but a few of the severely disabled to continue living at home. This represents a considerable saving on the cost of hospital-based care and has afforded them the best opportunity for developing their lives to the full and enjoying a satisfactory life in the community.