tbuckley/cabot-search huggingface dataset:
Assessment of coronary conductance and resistance vessel reactivity in response to nitroglycerin, ergonovine and adenosine: In vivo studies with simultaneous intravascular two-dimensional and Doppler ultrasound
Authors: Krishnankutty Sudhir, John S. MacGregor, Sophie D. Barbant, Elyse Foster, Peter J. Fitzgerald, Kanu Chatterjee, Paul G. Yock
Journal: Journal of the American College of Cardiology (1993)
Chopin's serpin
Authors: Adrian Reuben
Journal: Hepatology (2003)

Chopin's Serpin B efore you reach for Volume 5 of your wellthumbed set of the New Grove Dictionary of Music and Musicians, 1 stop and save yourself the time for you will not find a single serpin among the e ´tudes, preludes, nocturnes, mazurkas, polonaises, waltzes, and impromptus of Fryderyk Franciszek (Fre ´de ´ric Franc ¸ois) Chopin's melodious repertoire.On the other hand, perusal of his biography will soon show that throughout most of his tragically short life, Chopin, who came from an unhealthy family, was a sickly individual 2,3 ; and therein lies the clue to this month's Landmark in Hepatology.While it is generally believed that Chopin died of consumption 4 like a 19th Century operatic heroine, diagnoses other than tuberculosis, such as cystic fibrosis 5 and mitral stenosis, 6 have been tendered to explain his longstanding chronic respiratory symptoms.Born not far from Warsaw, to a French father (from Lorraine) and a Polish mother, Chopin (1810-1849) was a delicate child who fatigued easily and eschewed physical activity.Aside from early digestive problems, poor growth, and possible infertility, Chopin suffered continually from a cough that was often productive, and he had progressive exertional dyspnea.Chopin's father and Ludwika, his elder sister, were both subject to recurrent respiratory infection (of which Ludwika died at the age of 47 years), while his mother and Isabella, a younger sister, were quite healthy.Emilia, the youngest and sickest of the family, suffered repeatedly from paroxysms of coughing, wheezing and breathlessness, and repeated hematemesis.
Prescription Opioids and Overdose Deaths
Authors: Noni A. Graham
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The appropriateness of tympanostomy tubes for children
Authors: G. B. Healy
Journal: JAMA (1995)

To the Editor.  —I am deeply troubled by the article by Dr Kleinman and colleagues 1 regarding appropriateness of tympanostomy tubes. There are several issues of significant concern.  Their article compares criteria developed by a panel of experts retained by VHS with indications for tympanostomy tube insertion found in the charts of a number of otolaryngologists across the United States. It then concludes, based on these criteria, that approximately 25% of proposed tympanostomy tube insertions did not meet VHS criteria. Of interest is that VHS selected a panel of individuals, declared them experts, and then asked them to write criteria for the use of tympanostomy tubes. In addition, the authors state that participation in the expert panel should not infer that all those individuals uniformly endorsed the proposed criteria.  One must be mindful of the fact that VHS is a for-profit organization that sells software packages to third-party payers who
The quest for fire: hazards of a daily struggle.
Authors: John Manuel
Journal: Environmental Health Perspectives (2003)

ver since humans first nursed embers into flames with a pile of sticks, biomass fuels have played a key part in our survival.Biofuels delivered light, heat, and a means to cook food that was otherwise eaten raw.But that first whiff of smoke also signaled the arrival of a new set of health problems, for lungs were not meant to breathe soot, nor eyes to absorb smoke.Today, some 1 million years after humans learned to use fire, biofuels remain the principal fuel for heating and cooking for approximately one-third of the people on the planet, mostly in developing countries, according to the World Resources Institute.Biofuels are even enjoying a revival in the industrialized world, where they are seen as a less expensive and less polluting form of energy than fossil fuels.Yet severe health problems persist with burning traditional biofuels, and these problems particularly impact women and children.What are the promises and pitfalls of biofuels?And can they be used without sacrificing human health and harming the environment?
Report condemns social exclusion of people with mental illness
Authors: G. Yamey
Journal: BMJ (1999)

People with mental health problems are excluded from employment, education, and social services, according to a new report by the mental health charity Mind.

The report was based on oral and written testimonies from a range of individuals and organisations, including mental health service users, high street retailers, voluntary agencies, and NHS trusts. An independent panel used these submissions to identify the extent and causes of exclusion, and to make recommendations to promote inclusion.

The Mind inquiry discovered many openly discriminatory practices in workplaces with regard to mental illness. It also found …
Court awards record settlement for worker with RSI
Authors: C Dyer
Journal: BMJ (1994)

Union leaders are forecasting thousands of claims for compensation for repetitive strain injury from keyboard workers after last week's record £79 900 ($119 850) settlement for a typist who had worked for the Inland Revenue. The payment, to Kathleen Harris, aged 47, outstrips the previous record of £59 000 ($88 500) for a similar case.

The settlement comes three months after Judge John Prosser rejected a High Court claim by Rafiq Mughai, …
Substitution of Beclomethasone Aerosol for Oral Prednisolone in the Treatment of Chronic Asthma
Authors: S. J. Cameron, E. J. Cooper, G. K. Crompton, M. V. Hoare, I. W. B. Grant
Journal: BMJ (1973)

In a double-blind study 10 patients with chronic asthma received beclomethasone dipropionate 400 μg daily in a Freon propellant from a pressurized dispenser, and 10 patients received the Freon propellant alone. At the start of the trial each patient was receiving long-term maintenance treatment with oral prednisolone in a dose of 7·5 to 15 mg daily. The daily dose of prednisolone was reduced by 1 mg every four weeks and the patient9s progress followed by regular clinical assessment and studies of pituitary-adrenal function. The trial was continued until the dose of prednisolone was reduced to zero or until asthmatic symptoms increased to an unacceptable level. In the 10 patients who received beclomethasone the mean maintenance dose of oral prednisolone was reduced by 5·6 mg/day but in only two cases could this drug be withdrawn completely. In the placebo group the mean reduction in dose was only 1·3 mg, thus there was a significant difference between the two groups (P &lt;0·01). Studies of pituitary-adrenal function showed that a normal adrenal response to tetracosactrin stimulation returned only in the two patients from whom prednisolone was withdrawn. Hence the addition of beclomethasone dipropionate by inhalation to systemic corticosteroid therapy allows useful reductions to be made in the oral maintenance doses of corticosteroid. Reductions must be made with caution since there is wide individual variation in response to beclomethasone and in only a minority of patients can oral treatment by completely withdrawn.
Dilated cardiomyopathy created by chronic rapid pacing induces heat shock proteins and limits myocardial infarction in dogs
Authors: Anwar S. Abd-Elfattah, Jian-Hua Guo, El-Mostafa El-Gussab, Shin-Ping Gao, Andrew S. Wechsler
Journal: Journal of the American College of Cardiology (1996)
Morphometry of exercise-induced right ventricular hypertrophy in the rat.
Authors: P Anversa, V Levicky, C Beghi, S L McDonald, Y Kikkawa
Journal: Circulation Research (1983)

In our morphometric study of the effects of exercise on the heart, male Wistar-Kyoto rats at 5 weeks of age were subjected daily to a moderate treadmill running program that lasted for 7 weeks. The heart responded to physical conditioning by different magnitudes of tissue growth of the right (22%) and left (7%) ventricular myocardium, the latter change not statistically significant. The increase in right ventricular volume was associated with a 25% enlargement of ventricular area, a 26% average lengthening of the myocytes, and no change in sarcomere length and in ventricular midwall thickness. Exercise produced significant alterations in the quantitative parameters of the microvasculature of the right ventricle, but no appreciable changes in the left ventricle. Right ventricular hypertrophy was characterized by an absolute 44% growth of the endothelial luminal surface brought about through a 16% increase in capillary numerical density, and a 41% augmentation of the total length of the capillary network. Maximum diffusion distance from the capillary wall to the mitochondria of myocytes decreased 10% as a result of capillary proliferation and the lack of lateral expansion of myocyte cross-sectional area. Evaluation of the subcellular constituents of myocytes showed no change in the mitochondria:myofibrils volume ratio, indicating a growth of these components proportional to each other and to the growth of the myocyte population as a whole. It was concluded that, as a result of running exercise, right ventricular growth is analogous to eccentric hypertrophy in which the structural adaptations of the capillary bed can be expected to improve the diffusion and transport of oxygen within the tissue.
Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.
Authors: S Vukicevic, V Basic, D Rogic, N Basic, M S Shih, A Shepard, D Jin, B Dattatreyamurty, W Jones, H Dorai, S Ryan, D Griffiths, J Maliakal, M Jelic, M Pastorcic, A Stavljenic, T K Sampath
Journal: Journal of Clinical Investigation (1998)

We have shown that osteogenic protein-1 (OP-1) (bone morphogenetic protein-7) is responsible for the induction of nephrogenic mesenchyme during embryonic kidney development. Gene knock-out studies showed that OP-1 null mutant mice die of renal failure within the first day of postnatal life. In the present study, we evaluated the effect of recombinant human OP-1 for the treatment of acute renal failure after 60 min bilateral renal artery occlusion in rats. Bioavailability studies in normal rats indicate that approximately 1.4 microg OP-1/ml is available in the circulation 1 min after intravenous administration of 250 microg/kg, which then declines steadily with a half life of 30 min. About 0.5% of the administered OP-1 dose/g tissue is targeted for OP-1 receptors in the kidney. We show that OP-1 preserves kidney function, as determined by reduced blood urea nitrogen and serum creatinine, and increased survival rate when administered 10 min before or 1 or 16 h after ischemia, and then at 24-h intervals up to 72 h after reperfusion. Histochemical and molecular analyses demonstrate that OP-1: (a) minimizes infarction and cell necrosis, and decreases the number of plugged tubules; (b) suppresses inflammation by downregulating the expression of intercellular adhesive molecule, and prevents the accumulation and activity of neutrophils; (c) maintains the expression of the vascular smooth muscle cell phenotype in pericellular capillaries; and (d) reduces programmed cell death during the recovery. Collectively, these data suggest that OP-1 prevents the loss of kidney function associated with ischemic injury and may provide a basis for the treatment of acute renal failure.
Working Capacity of Women Doctors
Authors: J. Knowelden, J. E. Lunn
Journal: BMJ (1966)

BRmISNHimply criticism of the pneumoconiosis medi- cal panels, many of whose decisions are governed by the unsatisfactory state of present legislation.If emphysema in coal-workers is to come under further scrutiny, so should coronary heart disease.At present, enough prima facie evidence is available2-5 to suggest the existence of a high prevalence of this latter condition in coal-workers.Some of it admittedly carries the statistical disadvantages of necropsy -material.The main difficulty is to obtain accurate information about the prevalence of the condition in other occupa- tional groups.In the opinion of the writer the Registrar-General's returns are not suit- able for this purpose.In the meantime, if the miners are to be given the benefit of the doubt that clearly exists in respect of the occupational status of emphysema and coronary heart disease, let it be certain that it is not an illusory gain.-I am, etc.,
Zollinger-Ellison Syndrome: Current Concepts and Management
Authors: ROBERT T. JENSEN
Journal: Annals of Internal Medicine (1983)

Over the last few years the approach to managing patients with the Zollinger-Ellison syndrome has changed dramatically. The establishment of gastrin hypersecretion by a non-beta islet cell tumor as responsible for the gastric acid hypersecretion, and the subsequent development and widespread availability of gastrin radioimmunoassays have changed the criteria generally used for diagnosis and have led to an increased understanding of syndromes that can mimic Zollinger-Ellison syndrome. With the availability of histamine H2-receptor antagonists, gastric acid hypersecretion can be controlled medically in almost all patients with Zollinger-Ellison syndrome, obviating routine total gastrectomy. With the reduced mortality from gastric acid hypersecretion, increased attention is being focused on the natural history of the gastrinoma. Newer methods of localizing tumors are being investigated with a view to surgical removal of the gastrinoma, and the importance of developing an effective chemotherapeutic regimen is becoming increasingly apparent.
A Double‐Blind Evaluation of Topical Levocabastine, a New Specific H<sub>1</sub> Antagonist in Patients with Allergic Conjunctivitis
Authors: U. Pipkorn, M. Bende, J. Hedner, T. Hednerm
Journal: Allergy (1985)

Forty patients suffering from allergic conjunctivitis, due to birch pollen, participated in a double‐blind parallel group comparison between levocabastine (a potent new specific histamine (H 1 ) antagonist) and placebo, both given as eye drops. Symptom scores were recorded during a 4‐week period. A 1‐week run‐in period was followed by a 3‐week treatment period. To enable a fair evaluation of the treatment effect on the ocular symptoms only, all patients were treated with topical nasal glucocorticoids for possible rhinitis symptoms during the whole study period. Plasma levels of levocabastine were determined in all subjects at the end of the 3 weeks' treatment period. Pollen counts for birch pollen were followed simultaneously. The evaluation of the symptom score cards revealed a significant reduction of ocular symptoms following use of the active compound. The resorption of the active substance through the conjunctiva was low. In accordance with the present trend of more topical treatment for allergic rhinitis, levocabastine may constitute a valuable compound for the topical treatment of allergic conjunctivitis.
P1213 COMBINATION OF IFNL4 AND IFNL3 HAPLOTYPES IMPROVES PREDICTION OF RESPONSE TO INTERFERON THERAPIES IN PATIENTS FROM AN ADMIXED POPULATION
Authors: A.C. Nastri, F. Malta, P.L. Faria, K. Oliveira, F. Carrilho, J.R. Pinho
Journal: Journal of Hepatology (2014)
A double-blind crossover trial of egg and milk exclusion diets in atopic eczema
Authors: V.S. Neild, R.A. Marsden, J.A. Bailes
Journal: British Journal of Dermatology (1984)

Journal Article A double‐blind crossover trial of egg and milk exclusion diets in atopic eczema Get access V.S. Neild, V.S. Neild Department of Dermatology, St George's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar R.A. Marsden, R.A. Marsden Department of Dermatology, St George's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar J.A. Bailes J.A. Bailes Department of Dermatology, St George's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Page 33, https://doi.org/10.1111/j.1365-2133.1984.tb05256.x Published: 01 July 1984
Vi Agglutinins in Salmonella Infections
Authors: Steven A. Schroeder
Journal: JAMA (1971)

To the Editor:—  Reynolds et al in their case report of an elevated Widal O antigen titer due to an infection withSalmolnella typhimurium(214:2192-2193,1970), quoted a portion of the conclusion from my article on the serology of typhoid fever (206:839-840, 1968). Since their abbreviation somewhat alters the message I had intended to convey, I would like to present the entire conclusion as it appeared:  In conclusion, serologic tests for typhoid fever are nonspecific, poorly standardized, often confusing, and difficult to interpret. If serologic tests are used to diagnose typhoid fever, the titer for O antigen is the only meaningful value, and even this may be suppressed by early treatment with antibiotics, or elevated by immunization. Lack of standardized commercial antigens and cross-reactions with other salmonellae further confuse interpretation of these tests. An elevated Vi titer may be of some use in identifying a suspected typhoid carrier, but
Mumps Complicated by Myocarditis, Meningoencephalitis and Pancreatitis
Authors: John H. Bland
Journal: New England Journal of Medicine (1949)

MUMPS is usually considered to be an acute systemic disease of specific viral etiology with a special predilection for the parotid glands. The common complications are orchitis, pancreatitis, oöphoritis, mastitis and meningitis or meningoencephalitis, or both. Myocarditis has until the past few years been considered a rare and unusual complication. Several studies recently made call attention to the occurrence of myocarditis during the convalescent course of epidemic parotitis.It is the purpose of this paper to submit a case report as additional evidence to support the belief that mumps is a generalized infectious process and that the myocardium and pericardium . . .
Application of the Kidney to Aortic Blood Flow Index to Renal Transplants
Authors: PERCY DUNAGIN, MOHAMMAD ALIJANI, FRANK ATKINS, MARCIAL FAVILA, JAMES LIGHT
Journal: Clinical Nuclear Medicine (1983)

One hundred forty-nine standardized K/A ratios (renal bolus ascending slope: aortic bolus ascending slope) were performed on 33 post-transplant patients with acute or chronic rejection, obstruction, acute tubular necrosis, infection or acute hypertension after rapid intravenous injection of Tc-99m DTPA. The correlation of creatinine clearance versus the K/A ratio for 123 pairs of data performed on the same day was poor (r=0.37), but the correlation was greatly improved (r=0.72) when K/A ratio maxima or minima were compared with corresponding creatinine clearances performed during a nonrejection period, or acute rejection episode, respectively. Seventeen acute rejection episodes resulted in a 20% or greater decrease in the K/A ratio 16 times, but were observed as a change in the serial perfusion phase scintiphotos only five times, or in the function phase scintiphotos only six times. Of 27 significant decreases in K/A ratios, 22 were due to acute rejection, two to obstruction, one to infection, one to acute hypertension, and one was unexplained. Thus the K/A ratio is a sensitive but not specific index for following pathological changes in the renal allograft.
Diabetic osteopenia and circulating levels of vitamin D metabolites in type 2 (noninsulin-dependent) diabetes
Authors: Hitoshi Ishida, Yutaka Seino, Shigeru Matsukura, Masaki Ikeda, Mikio Yawata, Gentaro Yamashita, Seiichi Ishizuka, Hiroo Imura
Journal: Metabolism (1985)
PSYCHIATRIC EXPERIENCE IN THE WAR, 1941-1946
Authors: WILLIAM C. MENNINGER
Journal: American Journal of Psychiatry (1947)

Psychiatry in the Army did a reasonably creditable job primarily because of the devotion and integrity and ability of a small group of men. It failed in a good many ways and some of these failures were because we in psychiatry failed to select and train new and better men; because we were too inarticulate. Psychiatry has had opened to it great and broad vistas of opportunity and need, many of which were apparent following World War I. But it is saddening to see how few were followed and reached these needs. Perhaps psychiatry still is not ready to rise to the occasion to meet these needs. Perhaps its body of knowledge is not sufficiently great to tackle them. Our best hope lies in the cohesion of our forces, a plan of strategy, a conviction as to the importance of the job, and a self-sacrificing aggressive, militant leadership.
Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell–dependent induction of CD4+CD25+FoxP3+ Treg
Authors: Moanaro Biswas, Debalina Sarkar, Sandeep R. P. Kumar, Sushrusha Nayak, Geoffrey L. Rogers, David M. Markusic, Gongxian Liao, Cox Terhorst, Roland W. Herzog
Journal: Blood (2015)
Hypocalcaemia-induced pustular psoriasis-like skin eruption
Authors: Y. Lee, Y-H. Nam, J-H. Lee, J-K. Park, Y-J. Seo
Journal: British Journal of Dermatology (2005)

British Journal of DermatologyVolume 152, Issue 3 p. 591-593 Hypocalcaemia-induced pustular psoriasis-like skin eruption First published: 17 March 2005 https://doi.org/10.1111/j.1365-2133.2005.06460.xCitations: 14 Young-Joon Seo. E-mail: seoyj4u@cnuh.co.kr Conflicts of interest: none declared. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume152, Issue3March 2005Pages 591-593 RelatedInformation