tbuckley/cabot-search huggingface dataset:
Increased Focal Uptake of Tc-99m-IDA Hepatobiliary Agent by a Liver Metastasis
Authors: ARNOLD STRASHUN, STANLEY J. GOLDSMITH
Journal: Clinical Nuclear Medicine (1981)

A patient with fever and right upper quadrant abdominal pain was referred for a hepatobiliary scan. Tc-99m-PIPIDA scanning revealed a hypervascular hepatic focus that persisted as a “hot spot” in delayed views. Ga-67-citrate scanning revealed increased uptake in the same hepatic focus. The patient suddenly died. Postmortem examination revealed that this abnormal site represented a necrotic tumor histologically compatible with metastatic breast carcinoma.
Lichenoid Quinidine Eruption
Authors: J. S. Pegum
Journal: British Journal of Dermatology (1968)

Journal Article Lichenoid Quinidine Eruption Get access J. S. Pegum J. S. Pegum Department of Dermatology, The London Hospital, Whitechapel E.1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 5, 1 May 1968, Page 343, https://doi.org/10.1111/j.1365-2133.1968.tb12313.x Published: 01 May 1968
Coronary Artery Disease and Arteriosclerosis
Authors: Myron Prinzmetal, Constance Prinzmetal
Journal: JAMA (1964)

MANY INVESTIGATORS BELIEVE that the predisposition to coronary disease or arteriosclerosis can be detected by means of appropriate tests made on the living patient. These investigators generally base their predictions on the study of various types of blood lipids. Other factors such as anthropological bodily types, heredity, etc, are considered relevant. <h3>Studies Inadequate</h3> In spite of expenditures of large sums of money, such studies apparently have not been too helpful. In fact, in one well-known and expensive study, the differences of opinion among the investigators were not resolved. Some present plans, for example the determination of lipid factors followed by an electrocardiogram (ECG), have obvious defects. Studies involving the performance of similar tests with subsequent autopsies are also difficult to interpret for various reasons. To study large population groups for years or decades creates other obvious problems and is again extremely expensive. Can anything be done to meet these objections?
Endothelial Nuclear Patterns in the Canine Arterial Tree with Particular Reference to Hemodynamic Events
Authors: JOHN T. FLAHERTY, JOSEPH E. PIERCE, VICTOR J. FERRANS, DALI J. PATEL, W. Kirk TUCKER, DONALD L. FRY
Journal: Circulation Research (1972)

The objective of the study was (1) to measure systematically the orientation, morphology, and population density of endothelial nuclei of the canine thoracic aorta and its major branches and (2) to obtain evidence in a chronic in vivo preparation that altered flow patterns do indeed change patterns of nuclear orientation. For this purpose, a segment of the descending thoracic aorta was removed, opened longitudinally, and reclosed to form a tube with a new longitudinal axis 90° from the original vessel axis. The new segment was then sutured back in place. The animals were killed at suitable postoperative periods. Endothelial nuclear patterns were studied from en face photomicrographs of preparations stained with Evans blue dye. Results indicated: (1) In uniform vessel segments, e.g., middle and lower descending thoracic aorta, the nuclei were oriented parallel to the axis of the blood vessel, and the ratio of major to minor axes of the nucleus was large. The flow in these regions is known to be stable. (2) Nonaxial, less-ordered nuclear orientation with smaller ratios of major to minor axes were found in entrance regions of many major arteries and in the ascending aorta. (3) In chronic studies in which the flow pattern was altered, the nuclear pattern realigned in the direction of flow within 10 days after surgery.
Abstract C61: Reducing cancer incidence and mortality in African American, Arab American, and Chaldean communities in the Detroit metropolitan area utilizing a community-based participatory process
Authors: Vicky A. Dykes, Adil Akhtar, Stanley Berry, Ishmael Jaiyesimi, Vonda Douglas-Nikitin, Sugandh Shetty, Frank A. Vicini, Monty Fakhouri
Journal: Cancer Research (2009)

Abstract Purpose: We reviewed the impact of a community based participatory process (CBPP) addressing cancer education, prevention, and screening in two ethnic/minority populations to determine their impact on personal health related decisions. Materials and Methods: From 2005 – 2008, 2,281 community members participated in CBPP outreach efforts (cancer education, prevention and screening forums) conducted by the Beaumont Cancer Institute in cooperation with the Arab American and Chaldean Council, the National Cancer Institute and the American Cancer Society. The study population consisted of 1,067 (46.7%) individuals completing a post-cancer forum survey: 642 (60.2%) from the African American (AA) and 425 (39.8%) from the Arab American &amp; Chaldean (AAC) communities. Data were collected on behavioral intent and knowledge including: (1) forum content, (2) participants' cancer screening history, (3) symposium logistics (4) educational materials and (5) participation in subsequent cancer screening tests. Results: After attending at least one cancer education forum, 329 (30.8%) of the 1,067 participant respondents (14.4% of all attendees) underwent some type of cancer screening: 108 women (10.1%) underwent a screening mammogram, and 94 (8.8%) a pap smear. Thirty-eight men underwent (3.6%) a screening PSA, and 89 (8.3%) had other forms of cancer screenings (e.g. colonoscopy). Overall, 60.2% of AA versus 35% of ACC attendees completed a post-survey and 19.6% of AA versus 10% of AAC attendees underwent some type of cancer screening. Conclusions: The results of this study suggest that CBPP's based around perceived and/or serious diseases negatively affecting a target population can positively impact their personal health related decisions. Citation Information: Cancer Res 2009;69(23 Suppl):C61.
Exploring psychological complexity through dynamic systems theory: A complement to reductionism
Authors: Robert M. Galatzer-Levy
Journal: Behavioral and Brain Sciences (2005)

Dynamic systems theory (DS) provides tools for exploring how simpler elements can interact to produce complex psychological configurations. It may, as Lewis demonstrates, provide means for explicating relationships between two reductionist approaches to overlapping sets of phenomena. The result is a description of psychological phenomena at a level that begins to achieve the richness we would hope to achieve in examining psychological life as it is experienced and explored in psychoanalysis.
Tension-free Vaginal Tape for the Treatment of Urodynamic Stress Incontinence: Efficacy and Adverse Effects at 10-Year Follow-Up
Authors: Maurizio Serati, Fabio Ghezzi, Elena Cattoni, Andrea Braga, Gabriele Siesto, Marco Torella, Antonella Cromi, Domenico Vitobello, Stefano Salvatore
Journal: European Urology (2012)
Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors
Authors: Kazuo Minai, Tetsuya Matsumoto, Hajime Horie, Naoto Ohira, Hiroyuki Takashima, Hiroshi Yokohama, Masahiko Kinoshita
Journal: Journal of the American College of Cardiology (2001)
Bush wins changes in Medicare benefits
Authors: J. Lenzer
Journal: BMJ (2003)

After a bitter legislative fight, the US Congress passed a $395 billion revision of Medicare, the health insurance programme for elderly people, which will come into effect in 2006.

The Medicare Drug Benefit bill institutes far-reaching revisions of the popular programme created in 1965. The addition of outpatient prescription drug benefits attracted support from many quarters. But the bill's inclusion of privatisation schemes created a bitter divide with critics charging that the bill is the first step toward the dismantling of Medicare.

President George Bush's administration supported the bill saying its provisions encouraging privatisation create competition that will keep costs down and give elderly people a better range of choices.

Soaring drug costs fuelled the battle over changes in Medicare. Drug prices in the United States, often four to 10 times higher than in Canada and Europe, triggered a movement to legalise the reimportation of drugs. But the new Medicare drug plan prohibits both drug reimportation and price negotiations by Medicare.

“[This …
Are hospital patients fellow human beings?
Authors: F. Reynolds
Journal: BMJ (1996)

“Of course they are,” you cry. Yes, we all agree they are human beings, but the question is, are they fellow human beings?

In the early 1950s polio was endemic in England. One summer, at the age of 17, I suffered the classical minor illness followed by a major illness with severe meningism and our family doctor had no difficulty in diagnosing polio. I was admitted to our local fever hospital, which had become a branch of one of the 12 London teaching hospitals.

Luckily the illness was non-paralytic and not severe, though I shared a room with two girls in iron lungs. The houseman was kind and efficient and an excellent communicator. I remember him sitting down beside my bed and explaining that the majority of people catching polio at that time were not permanently paralysed. I found this most reassuring, which was important since as a child the words infantile paralysis had struck terror in my heart. Moreover, I had had friends both afflicted with …
Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors
Authors: C Wichmann, I Quagliano-Lo Coco, Ö Yildiz, L Chen-Wichmann, H Weber, T Syzonenko, C Döring, C Brendel, K Ponnusamy, A Kinner, C Brandts, R Henschler, M Grez
Journal: Leukemia (2014)

The RUNX1/ETO (RE) fusion protein, which originates from the t(8;21) chromosomal rearrangement, is one of the most frequent translocation products found in de novo acute myeloid leukemia (AML). In RE leukemias, activated forms of the c-KIT tyrosine kinase receptor are frequently found, thereby suggesting oncogenic cooperativity between these oncoproteins in the development and maintenance of t(8;21) malignancies. In this report, we show that activated c-KIT cooperates with a C-terminal truncated variant of RE, REtr, to expand human CD34+ hematopoietic progenitors ex vivo. CD34+ cells expressing both oncogenes resemble the AML-M2 myeloblastic cell phenotype, in contrast to REtr-expressing cells which largely undergo granulocytic differentiation. Oncogenic c-KIT amplifies REtr-depended clonogenic growth and protects cells from exhaustion. Activated c-KIT reverts REtr-induced DNA damage and apoptosis. In the presence of activated c-KIT, REtr-downregulated DNA-repair genes are re-expressed leading to an enhancement of DNA-repair efficiency via homologous recombination. Together, our results provide new mechanistic insight into REtr and c-KIT oncogenic cooperativity and suggest that augmented DNA repair accounts for the increased chemoresistance observed in t(8;21)-positive AML patients with activated c-KIT mutations. This cell-protective mechanism might represent a new therapeutic target, as REtr cells with activated c-KIT are highly sensitive to pharmacological inhibitors of DNA repair.
Progress in the Biological Sciences in Relation to Dermatology
Authors: P. C. Anderson
Journal: JAMA (1965)

An excellent symposium concerning investigative dermatology was held in Cambridge, England, in the autumn of 1963 and was attended by many fluent, thoughtful, and stimulating investigators. They discussed collagen, capillaries, fat, keratin, hair, blisters, repair, aging, and epidermal barrier and reviewed some new techniques in research; they contributed 46 uniformly commendable papers. Because each section is introduced by a thorough review of the problem, the book may be especially useful to students of clinical dermatology. The reader is not required to have a detailed knowledge of research methods. For example, Spearman's introduction to the genetics of keratinization and Breathnach's discussion of the dermo-epidermal junction are cogent and readable reviews. Lasnitzki has summarized recent applications of organ-culture methods to the study of the skin. The treatment of explanted epidermis with hydrocortisone, vitamin A, or certain allergens or carcinogens produced interesting results, most of which were published in journals not regularly con
Oral psoralen photochemotherapy of atopic eczema
Authors: WARWICK L. MORISON, JOHN A. PARRISH, THOMAS B. FITZPATRICK
Journal: British Journal of Dermatology (1978)

Journal Article Oral psoralen photochemotherapy of atopic eczema Get access WARWICK L. MORISON, WARWICK L. MORISON Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar JOHN A. PARRISH, JOHN A. PARRISH Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar THOMAS B. FITZPATRICK THOMAS B. FITZPATRICK Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 98, Issue 1, 1 January 1978, Pages 25–30, https://doi.org/10.1111/j.1365-2133.1978.tb07329.x Published: 01 January 1978
Tranexamic Acid in Control of Haemorrhage after Dental Extraction in Haemophilia and Christmas Disease
Authors: C. D. Forbes, R. D. Barr, G. Reid, C. Thomson, C. R. M. Prentice, G. P. M. Nicol, A. S. Douglas
Journal: BMJ (1972)

In a double-blind trial tranexamic acid (AMCA, Cyclokapron), 1 g three times a day for five days, significantly reduced blood loss and transfusion requirements after dental extraction in patients with haemophilia and Christmas disease. No side effects were seen in either group of patients. Screening tests showed no toxic action of tranexamic acid on the liver, kidney, or heart.
Incidence of Pathogenic Serologic Types of<i>Escherichia coli</i>among Neonatal Patients in the New England Area
Authors: Michael Curtin, Stewart H. Clifford
Journal: New England Journal of Medicine (1956)

ANTIGENICALLY homogenous strains of Escherichia coli (var. neopolitana) were isolated from infants with summer diarrhea in London by Bray1 in 1945. Since then several of the four serotypes of Esch. coli have been found in hospital outbreaks of infantile gastroenteritis throughout the world,2 3 4 5 6 7 8 9 10 and the pathogenic role of some of these serotypes has been further demonstrated by administration of live cultures to adult volunteers.11 12 13 In epidemics the newborn infant is extremely susceptible whereas older infants are relatively resistant. Although outbreaks have been characterized by a high infectivity rate among infant contacts, there have been differing reports on the frequency . . .
First-pass nuclear magnetic resonance imaging studies using gadolinium-DTPA in patients with coronary artery disease
Authors: Warren J. Manning, Dennis J. Atkinson, William Grossman, Sven Paulin, Robert R. Edelman
Journal: Journal of the American College of Cardiology (1991)

Nuclear magnetic resonance (NMR) imaging has been shown to accurately portray cardiac anatomy and function. To investigate the potential of NMR imaging for the assessment of coronary stenosis in patients with chest pain, ultrafast NMR imaging in conjunction with a T1(longitudinal relaxation time) contrast agent was performed in 17 patients with chest pain who had undergone cardiac catheterization. These included 12 patients with significant coronary artery stenoses and 4 who underwent repeat NMR study after myocardial revascularization. Cardiac images at rest were obtained during rapid intravenous injection of gadolinium-DTPA (0.04 mM/kg). Electrocardiographic-gated images were acquired over 380 ms, with repetitive images obtained every 3 to 4 s. After contrast injection, there was pronounced signal enhancement in the right ventricular cavity, followed by enhancement in the left ventricular cavity and myocardium. Regional myocardium perfused by a diseased vessel demonstrated a lower peak signal intensity (p = 0.001) and lower rate of signal increase (p = 0.001) than did myocardium perfused by coronary arteries without stenosis. Repeat NMR study after revascularization showed an increase in peak signal intensity (p < 0.002). These results demonstrate the clinical potential of dynamic gadolinium-DTPA-enhanced NMR imaging for the assessment of coronary artery disease in patients with chest pain. In combination with anatomic and functional NMR imaging, this technique has the potential to provide a comprehensive noninvasive cardiac evaluation of patients with suspected coronary artery disease.
Establishing ethical trials for treatment and prevention of AIDS in developing countries
Authors: B. Lo
Journal: BMJ (2003)

Developing countries have been hardest hit by HIV but often cannot afford the expensive drugs or high tech health care used in Western countries. How can researchers and sponsors of trials investigating treatment and prevention of HIV in developing countries make sure they take proper account of local conditions? As the HIV epidemic continues to spread, clinical and prevention trials are needed in developing nations to learn how best to alleviate suffering. Such international trials, however, raise ethical concerns because of great disparities in wealth, power, and medical infrastructure and a history of exploitation. Several reports suggest broad ethical and policy guidelines for trials in developing countries (box 1).1–5 However, such guidelines may be too general to resolve many controversies that arise in the context of specific trials.4 Because of substantive disagreements regarding such international trials, measures that assure procedural fairness are vital. We argue that partnerships between developed and developing countries are essential to working out ethical problems that arise in particular trials and propose steps to ensure that such partnerships are effective. For research to be effective, partnerships must be established with researchers, government agencies, and community leaders in host countries at the planning stage of trials. It is all too common for host country partners to be presented with detailed protocols developed primarily by investigators and sponsors from developed nations and then given the opportunity to comment.6 This is too little, too late. #### Box 1: Guidelines for clinical and prevention trials in developing nations1–5
Generic GPCR residue numbers – aligning topology maps while minding the gaps
Authors: Vignir Isberg, Chris de Graaf, Andrea Bortolato, Vadim Cherezov, Vsevolod Katritch, Fiona H. Marshall, Stefan Mordalski, Jean-Philippe Pin, Raymond C. Stevens, Gerrit Vriend, David E. Gloriam
Journal: Trends in Pharmacological Sciences (2014)
To Reconstruct or Not to Reconstruct?
Authors: Randolph Sherman
Journal: New England Journal of Medicine (2002)

In the opening scene of the movie “Dances with Wolves,” dazed Union Army soldiers with mangled limbs are laid out, resigned to their turn at the surgeon's cleaver. This scene is typical of health care in the mid-19th century, when severe leg trauma would more often than not result in early amputation. Now, 150 years later, the debate continues over whether complex limb salvage or early amputation followed by fitting of a prosthesis is most likely to allow return to a normal lifestyle.Progress in leg reconstruction has been marked by clearly defined steppingstones interspersed with decades of stagnation in . . .
Non-Hodgkin's Lymphoma of the Spinal Cord
Authors: A. Routh
Journal: CA A Cancer Journal for Clinicians (1980)

A 57-year-old white female, operated on for a prolapsed disc six years ago, presented with low back pain. Initially, she was thought to be suffering from the same disc problem, and was treated accordingly. However, her condition worsened. A myelogram disclosed a complete block of the subarachnoid space from levels T11 to L2. Laminectomy and decompression were performed, revealing tumor in the extradural space. Histological examination disclosed a primary, poorly differentiated lymphocytic lymphoma of the spinal cord. Both primary and metastatic nin-Hodgkin's lymphoma of the spinal cord are extremely rare. Mullins et al described only five instances of cord compression in a study of 529 cases of nin-Hodgkin's lymphoma. The diagnosis is generally not suspected until laminectomy.
Letter: Incidence of idiopathic venous thromboembolism in nurses.
Authors: D A Tibbutt, E W Williams, T Faulkner
Journal: BMJ (1973)

first discovered to be hypertensive two months before her myocardial infarction.The third patient was a single girl from the Continent who had taken oral contraceptives for three years.We have no previous medical records about her.We do not consider that our report of 22 women under the age of 45 years with acute myocardial infarction represents "a small amount of inadequate information" upon which to base recommendations.It is the largest series yet assembled and we were particularly careful not to draw over- emphatic conclusions.-Weare, etc.,
The Effect of Oxandrolone on the Healing of Chronic Pressure Ulcers in Persons With Spinal Cord Injury
Authors: William A. Bauman, Ann M. Spungen, Joseph F. Collins, Dennis W. Raisch, Chester Ho, George A. Deitrick, Bernard A. Nemchausky, Lance L. Goetz, Jai S. Park, Michael Schwartz, John L. Merritt, Vidya Jayawardena, Paul Sandford, Sunil Sabharwal, Sally A. Holmes, Fahima Nasar, Roy Sasaki, Vandana Punj, Karin F. Zachow, Walter C. Chua, MaryKutty D. Thomas, Rose C. Trincher†
Journal: Annals of Internal Medicine (2013)

Chinese translation Background: Anabolic steroids have been reported to improve wound healing. Objective: To determine whether oxandrolone increases the percentage of target pressure ulcers (TPUs) that heal compared with placebo and whether healed ulcers remain closed 8 weeks after treatment. Design: Parallel-group, placebo-controlled, randomized trial conducted from 1 August 2005 to 30 November 2008. Patients, clinical care providers, study personnel, and statisticians were blinded to treatment assignment. (ClinicalTrials.gov: NCT00101361) Setting: 16 inpatient spinal cord injury (SCI) services at Veterans Affairs medical centers. Patients: 1900 prescreened, 779 screened, and 212 randomly assigned inpatients with SCI and stage III or IV TPUs. Intervention: Oxandrolone, 20 mg/d (n = 108), or placebo (n = 104) until the TPU healed or 24 weeks. Measurements: The primary outcome was healed TPUs. The secondary outcome was the percentage of TPUs that remained healed at 8-week follow-up. Results: 24.1% (95% CI, 16.0% to 32.1%) of TPUs in oxandrolone recipients and 29.8% (CI, 21.0% to 38.6%) in placebo recipients healed (difference, −5.7 percentage points [CI, −17.5 to 6.8 percentage points]; P = 0.40). At 8-week follow-up, 16.7% (CI, 9.6% to 23.7%) of oxandrolone recipients and 15.4% (CI, 8.5% to 22.3%) of placebo recipients retained a healed TPU (difference, 1.3 percentage points [CI, −8.8 to 11.2 percentage points]; P = 0.70). No serious adverse events were related to oxandrolone. Liver enzyme levels were elevated in 32.4% (CI, 23.6% to 41.2%) of oxandrolone recipients and 2.9% (CI, 0.0% to 6.1%) of placebo recipients (P < 0.001). Limitations: Selection of severe wounds may have reduced treatment response. Approximately one third of patients did not complete the study in the treatment and placebo groups. The study was terminated after a futility analysis showed a low probability of detecting a significant difference between the groups. Conclusion: Oxandrolone showed no benefit over placebo for improving healing or the percentage of TPUs that remained closed after 8 weeks of treatment. Primary Funding Source: U.S. Department of Veterans Affairs.