tbuckley/cabot-search huggingface dataset:
Abstract 2855: SRC represents a potential therapeutic target in liposarcoma
Authors: Elisabeth Sievers, Marcel Trautmann, Dagmar Kindler, Florence Pedeutour, Pierre Aman, Jun Nishio, Eva Wardelmann, Reinhard Büttner, Wolfgang Hartmann
Journal: Cancer Research (2012)

Abstract Liposarcomas (LS) represent the most common malignant soft tissue tumors in adults. Therapeutic outcome of LS is mainly determined by the efficiency of surgery as a high tendency for local relapse is seen. Chemo- and radiotherapy represent further therapeutic options, however, specifically targeted therapies are currently not available. The oncoprotein SRC is a tyrosine kinase, which has been shown to be activated in a variety of human cancers. SRC activation plays an important role in cancer cell proliferation, survival, angiogenesis and motility. In this work we analyzed LS biopsies comprising the main different subgroups, i.e. myxoid (MLS), well/dedifferentiated (WDLS/DDLS) and pleomorphic (PLS) LS and corresponding cell lines regarding SRC activation and studied the biological effects of SRC inhibition. Based on data derived from phospho-kinase screens in LS cells, immunhistochemical stainings of (Tyr416)-phosphorylated (p)-SRC were performed in primary LS biopsies. LS cell lines treated with the SRC inhibitor dasatinib were analyzed for phosphorylation of SRC and its downstream signaling molecules, cell proliferation, migration and apoptosis. Furthermore, synergistic effects of simultaneous treatments with dasatinib and conventional cytotoxic drugs were investigated. Particularly WDLS/DDLS and MLS tumor cells showed a significant expression of p-SRC. In LS cell lines, inhibition of SRC with dasatinib resulted in a substantially impaired cellular growth accompanied by a decreased phosphorylation of SRC and its downstream targets. Flow cytometric analysis showed that effects of SRC inhibition were due to an increase in apoptosis (cleaved PARP(Asp 214)) and a decrease of cellular proliferation (phospho-(Ser10) Histone H3). Scratch and Boyden chamber assays indicated a diminished migratory potential of the tumor cells due to SRC inactivation. Simultaneous treatment of liposarcoma cell lines with dasatinib and chemotherapeutic drugs resulted in additive effects. Our data suggest that SRC kinase activation represents an important biological feature of LS which might be successfully addressed in targeted therapeutic approaches. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2855. doi:1538-7445.AM2012-2855
Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation.
Authors: A Young, R J Levin
Journal: Gut (1990)

The effects of progressive starvation for up to three days on the basal and secretagogue stimulated secretory functions of the rat ileum were investigated in vitro and in vivo. The secretagogues used included agents acting via cyclic AMP (dibutyryl cyclic AMP, theophylline, forskolin, and PGE2) and those acting via Ca++ (acetylcholine, bethanecol, carbachol, 5-hydroxytryptamine, and A23187). Starving rats for 24 h (day 1) had no effect on the basal electrogenic secretion (measured as the short circuit current, Isc muamps/cm2) or on the stimulated maximum electrogenic secretion (measured as the delta Isc where delta Isc = maxIsc-basal Isc). By day 2 of starvation, however, both the basal Isc and the delta Isc induced by all the secretagogues were significantly greater than in the fed and increased even more on day 3. Replacement of all the chloride ions and inhibition by furosemide indicated that the enhanced secretion was due mainly to chloride ions. Cholinergic stimulation was blocked by atropine, indicating the stimulation was via muscarinic receptors while cholinergic dose - delta Isc response curves for fed and starved ilea showed significantly increased maximum electrogenic secretory response in the latter but no evidence of any change in the affinity (ED50) of the receptors mediating the response. The basal secretion and the secretory response to acetylcholine in both fed and starved ilea was unaffected by tetrodotoxin, revealing that the enhanced secretory response could be expressed via the muscarinic receptors on the enterocytes without the enteric neural network. Measurement of ileal fluid movement in vivo showed that in fed and day 1 starved rats the basal, unstimulated 9tone9 of the ileum was absorptive. On day 2, however, the basal 9tone9 had reversed to one of secretion which increased further on day 3. Stimulation of fluid secretion in vivo by bethanecol, carbachol, or PGE2 induced larger increases in the starved ilea by day 2 which increased even further on day 3. Lumenal chloride and bicarbonate concentrations were greater in the starved ileal fluid than in the fed. The studies in rat ileum confirm and extend those on rat jejunum and indicate that starvation creates a hypersensitive small bowel that responds to secretagogues and cholinergic neurotransmitters with a greatly enhanced secretory response.
Intra-epidermic Vaccination
Authors: E. R. Peirce
Journal: BMJ (1937)

left tube.The patient's condition then improved, but during the night she was seized with colicky pains, evidently the attempt at abortion of the part of the right tube.In both cases she referred the pain to the centre of the lower abdomen.The physical findings were not helpful in aiding the diagnosis of bilateral tubal pregnancy, but in the light of subsequent findings the extreme tenderness on the right side in conjunction with the tumour on the left should have suggested the possibility.The question of the relative ages of the pregnancies in this case it is impossible to decide.The periods had been regular till six weeks before the onset of the illness, and it is therefore reasonable to assume that both pregnancies were of equal development.Neither foetus was recovered, so help from that source is lacking.Finally, there was only one corpus luteum of pregnancy.It is probable that this was a case of simultaneous bilateral tubal gestation, but further than this it is impossible to go.The aetiology of tubal pregnancy is still sub judice.That inflammatory changes are frequent precursors of tubal pregnancy is, however, extremely probable, and in this case the history of three previous attacks of lower abdominal pain is very suggestive of salpingitis being at least a predisposing factor.Finally, with regard to treatment opinions vary.Lockyer (1917) considers that the possession of a normally menstruating uterus is of great importance to the mental outlook of the patient.Launay and Seguinot (1911) con- sider that in such cases it is often impossible to tell ovary from tube; that both are grossly disorganized and both may need to be removed.They argue, then, that the uterus is superfluous when both tubes and ovaries are removed, and a subtotal hysterectomy permits of better toilette of the pelvic cavity and reperitonization of the raw areas.Beckwith Whitehouse (1935) advocates conservation of the ovaries when possible and also of the uterus, unless special circumstances call for its removal.Undoubtedly if the condition is diagnosed before rupture double salpingectomy is sufficient.After rupture, when the patient is suffering from shock and haemorrhage, the minimum of surgical intervention necessary to relieve the condition seems indicated, and therefore the author is in favour of double salpingectomy, conserving the ovaries, or at least a portion of the ovaries, whenever possible.
MOST NEGATIVELY CHARGED SUBFRACTION (L5) OF PLASMA LDL PROLONGS ACTION POTENTIAL DURATION OF RAT CARDIOMYOCYTES VIA LOX-1 RECEPTORS
Authors: Nancy Cheng, Jonathan Lu, Junping Sun, Geru Wu, Shahrzad Abbasi, Jia Zhang, Jie Cheng, Chu-Huang Chen, Yutao Xi
Journal: Journal of the American College of Cardiology (2011)
TREATMENT OF CHILDHOOD COMBINED EPSTEIN-BARR VIRUS/CYTOMEGALOVIRUS INFECTION WITH ORAL BOVINE TRANSFER FACTOR
Authors: JamesF. Jones, WayburnS. Jeter, VincentA. Fulginiti, LindaL. Minnich, RandallF. Pritchett, RalphJ. Wedgwood
Journal: The Lancet (1981)
Dimensions of rationing: who should do what?
Authors: R Klein
Journal: BMJ (1993)

Priority setting is a complex interaction of multiple decisions at various levels in the organisation and constrained by history. There is no self evident set of ethical principles or analytical tools to determine what decisions we should take at various levels, nor is there an obvious or easy way to resolve the clash of claims on resources. To make priority setting more "rational" we should concentrate on the processes and structure of decision making and the relation of macro and micro decisions. The debate should promote reasoned, informed, and open argument, draw on a variety of perspectives, and involve a plurality of interests. The aim must be to build up, over time, the capacity to engage in continuous, collective argument.
Is any involvement with the UK military unethical?
Authors: Nick Wilson
Journal: BMJ (2006)

EDITOR—There are good ethical arguments for UK military staff to now refuse to participate in the military involvement in Iraq, as highlighted by the case of Kendall-Smith.1 But are there major ethical problems with any association with the British military? Its possession of nuclear weapons and its failure to make substantive progress phasing these out,2 despite disarmament being legally required by Article …
Enhancement of Cellular Accumulation of Cyclosporine by Anti-P-glycoprotein Monoclonal Antibody MRK-16 and Synergistic Modulation of Multidrug Resistance
Authors: M. Naito, H. Tsuge, C. Kuroko, T. Koyama, A. Tomida, T. Tatsuta, Y. Heike, T. Tsuruo
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Enhancement of Cellular Accumulation of Cyclosporine by Anti-P-glycoprotein Monoclonal Antibody MRK-16 and Synergistic Modulation of Multidrug Resistance Get access Mikihiko Naito, Mikihiko Naito Institute of Applied Microbiology, University of TokyoJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar Harumi Tsuge, Harumi Tsuge Institute of Applied Microbiology, University of TokyoJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar Chie Kuroko, Chie Kuroko Institute of Applied Microbiology, University of TokyoJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar Tomoko Koyama, Tomoko Koyama Institute of Applied Microbiology, University of TokyoJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar Akihiro Tomida, Akihiro Tomida Institute of Applied Microbiology, University of TokyoJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar Tohru Tatsuta, Tohru Tatsuta Institute of Applied Microbiology, University of TokyoJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuji Heike, Yuji Heike Cancer Chemotherapy Center, Japanese Foundation for Cancer ResearchTokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar Takashi Tsuruo Takashi Tsuruo Institute of Applied Microbiology, University of TokyoJapanCancer Chemotherapy Center, Japanese Foundation for Cancer ResearchTokyo Correspondence to: Takashi Tsuruo, Ph.D., Institute of Applied Microbiology, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 4, 17 February 1993, Pages 311–316, https://doi.org/10.1093/jnci/85.4.311 Published: 17 February 1993 Article history Received: 25 August 1992 Revision received: 02 November 1992 Accepted: 05 November 1992 Published: 17 February 1993
Jehovah's Witnesses May Not Have Identical Outcomes With Nontransfused Non-Witnesses After Cardiac Surgery—Reply
Authors: Gregory Pattakos, Colleen G. Koch, Eugene H. Blackstone
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract B3: Relevance of genotyping non-small-cell lung cancer patients on response to platinum-basedchemotherapy and tyrosine kinase inhibitors
Authors: Alma D. Campos-Parra, Graciela Cruz, Carlos Zuloaga, Alejandro Aviles, María E. Vázquez Manríquez, José R. Borbolla-Escoboza, Andrés Cardona, Meneses Abelardo, Oscar Arrieta
Journal: Clinical Cancer Research (2012)

Abstract Background: Subdividing non-small cell lung cancer (NSCLC) based on molecular alterations such as EGFR, KRAS and ALK genes is important for selecting treatment involving EGFR and EML4-ALK tyrosine kinase inhibitors (TKI). However, little information is available comparing patients' response and progression-free survival in the presence or absence of EGFR, KRAS mutations or the EML4-ALK fusion gene when being treated with chemotherapy. Methods: NSCLC patients were treated with chemotherapy and/or TKIs. Tests were performed for EGFR and KRAS gene mutation as well as EML4-ALK fusion genes. Progression-free survival and overall survival association with type of treatment and mutational status was analyzed. Results: The factors associated with a response to chemotherapy were the presence of EGFR and KRAS mutation (p = 0.006 and p = 0.028, respectively). Factors associated with TKI response were adenocarcinoma (HR 2.7: 1.6–4.6 95%CI; p&amp;lt;0.001), EGFR mutation (HR 0.5: 0.3–0.8 95%CI; p = 0.009) and wild-type KRAS (HR 1.7: 1.1–2.8 95%CI; p = 0.013). Mean progression-free survival in the chemotherapy group was 5.3 months (4.8–5.7 95%CI). Conclusion: EGFR and KRAS mutation status appeared to subdivide NSCLC patients into TKI and chemotherapy response groups.
Effect of Different Intensities of Exercise on Endothelium-Dependent Vasodilation in Humans
Authors: Chikara Goto, Yukihito Higashi, Masashi Kimura, Kensuke Noma, Keiko Hara, Keigo Nakagawa, Mitsutoshi Kawamura, Kazuaki Chayama, Masao Yoshizumi, Isao Nara
Journal: Circulation (2003)

Background— Aerobic exercise enhances endothelium-dependent vasodilation in hypertensive patients, patients with chronic heart failure, and healthy individuals. However, it is unclear how the intensity of exercise affects endothelial function in humans. The purpose of the present study was to determine the effects of different intensities of exercise on endothelium-dependent vasodilation in humans. Methods and Results— We evaluated the forearm blood flow responses to acetylcholine, an endothelium-dependent vasodilator, and isosorbide dinitrate, an endothelium-independent vasodilator, before and after different intensities of exercise (mild, 25% V̇ o 2 max; moderate, 50% V̇ o 2 max; and high, 75% V̇ o 2 max; bicycle ergometers, 30 minutes, 5 to 7 times per week for 12 weeks) in 26 healthy young men. Forearm blood flow was measured using a mercury-filled Silastic strain-gauge plethysmograph. Twelve weeks of moderate-intensity exercise, but not mild- or high-intensity exercise, significantly augmented acetylcholine-induced vasodilation (7.5±2.4 to 11.4±5.8 mL/min per 100 mL tissue; P &lt;0.05). No intensity of aerobic exercise altered isosorbide dinitrate–induced vasodilation. The administration of N G -monomethyl- l -arginine, a nitric oxide synthase inhibitor, abolished the moderate-intensity exercise-induced augmentation of the forearm blood flow response to acetylcholine. High-intensity exercise increases plasma concentrations of 8-hydroxy-2′-deoxyguanosine (from 6.7±1.1 to 9.2±2.3 ng/mL; P &lt;0.05) and serum concentrations of malondialdehyde-modified low-density lipoprotein (from 69.0±19.5 to 82.4±21.5 U/L; P &lt;0.05), whereas moderate exercise tended to decrease both indices of oxidative stress. Conclusions— These findings suggest that moderate-intensity aerobic exercise augments endothelium-dependent vasodilation in humans through the increased production of nitric oxide and that high-intensity exercise possibly increases oxidative stress.
A pilot study of alemtuzumab (anti-CD52 monoclonal antibody) therapy for patients with relapsed or chemotherapy-refractory peripheral T-cell lymphomas
Authors: Gunilla Enblad, Hans Hagberg, Martin Erlanson, Jeanette Lundin, Anja Porwit MacDonald, Roland Repp, Johannes Schetelig, Gernot Seipelt, Anders Österborg
Journal: Blood (2004)
Impact of continuous ambulatory peritoneal dialysis on treatment of renal failure in patients aged over 60.
Authors: A J Nicholls, S Waldek, M M Platts, P J Moorhead, C B Brown
Journal: BMJ (1984)

Thirty eight patients aged over 60 with end stage renal disease were treated by continuous ambulatory peritoneal dialysis for up to three years. Most of these patients, because of their age or coexisting diseases, had been considered to be unsuitable for haemodialysis by the criteria used before the advent of continuous ambulatory peritoneal dialysis in 1980. Actuarial patient survival at one and two years was 72% and 61% respectively, and only two patients were permanently transferred to haemodialysis. Twenty one of the 23 survivors were fully rehabilitated, the remaining two being partially disabled but living at home. Continuous ambulatory peritoneal dialysis permits more liberal selection of patients with end stage renal disease for renal replacement treatment with excellent survival and rehabilitation and without overburdening scarce hospital haemodialysis facilities.
The Efficacy and Safety of the Tension-Free Vaginal Tape Procedure Do Not Depend on the Method of Analgesia
Authors: Aneta Adamiak, Paweł Milart, Paweł Skorupski, Katarzyna Kuchnicka, Andrzej Nestorowicz, Jerzy Jakowicki, Tomasz Rechberger
Journal: European Urology (2002)
Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy
Authors: Lawrence Rice, Janet L. Nichol, Robert McMillan, Lorin K. Roskos, Margaret Bacile
Journal: American Journal of Hematology (2001)

Abstract We report a patient with cyclic thrombocytopenia and antiplatelet antibodies, a variant of chronic immune thrombocytopenic purpura (ITP), with a several year history of periodic fluctuation of the platelet count, megakaryocytic hyperplasia and high‐titer anti‐GPIb‐specific antiplatelet antibodies. The patient was resistant to multiple forms of therapy but has responded to the thrombopoietic growth factor, pegylated recombinant human megakaryocyte growth and development factor (PEG‐rHuMGDF). This case suggests that some patients with classic ITP may respond to thrombopoietic growth factors. Am. J. Hematol. 68:210–214, 2001. © 2001 Wiley‐Liss, Inc.
Preliminary results of the Phase IIa trial of a folate binding protein (FBP) adjuvant cancer vaccine (E39+GM-CSF) in ovarian and endometrial cancer patients to prevent recurrence
Authors: Julia Greene, Erika Schneble, John Berry, Alfred Trappey, Timothy Vreeland, Guy Clifton, William McGuire, George Maxwell, Sathibalan Ponniah, George Peoples
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts FBP (aka Folate Receptor-a) is an immunogenic protein that is over-expressed in breast, endometrial (EC) and ovarian cancer (OC). FBP expression in malignant cells is 20-80 fold higher compared to the limited distribution in normal cells. We have completed enrollment of a Phase
Doctors fear that inequalities are slipping down agenda
Authors: K. Burke
Journal: BMJ (1999)

Public health specialists in England fear that health inequalities are slipping down the government's agenda as two new policy documents have failed to set national targets for closing the health gap.

Neither last week's white paper on public health nor an official report on health inequalities, published with minimal publicity at the same time, set national targets, and neither offered any extra money to improve health in the country's poorest boroughs.

Although the government plans to save 300000 lives over the next 10 years—from suicide, cancer, accidents, and heart disease and strokes—no parallel targets have been set to tackle health inequalities, and none of the £96m ($154m) public health development fund pledged in the white paper, Saving …
Health needs of Zimbabweans are poorly recognised in UK
Authors: Steve Gillam, Raj Khanchandani, Melusi Ndebele
Journal: BMJ (2004)

EDITOR—In 2002 Zimbabweans were the second largest group of asylum seekers coming to the United Kingdom, 7695 asylum applications having been made,1 and they constitute one of the largest migrant groups of English speaking peoples from a developing country for 25 years. The lack of language barriers may help this community to use the NHS more effectively than earlier migrants, but they may face discrimination …
An Approach to Occupational Therapy
Authors: H. J. Glanville
Journal: Annals of the Rheumatic Diseases (1978)

The second part is the S) bution to the anniversary n consists of papers on diverse t4 is a survey of 10 years of worn on articular chondrocalcinc papers on proteases and arthriIf you were at the meetir probably wish to have the mc a permanent record of the I and if you are interested in dru might wish to borrow a copy.
Prognostic value of nucleoli and cell size in chronic lymphocytic leukemia
Authors: Howard N. Dubner, John J. Crowley, Robert F. Schilling
Journal: American Journal of Hematology (1978)

Abstract In an effort to improve prediction of duration of survival in chronic lymphocytic leukemia, correlations between blood‐cell morphology and survival were investigated. Blood films made on 108 patients at the time of diagnosis of chronic lymphocytic leukemia were reviewed by a single hematologist. Lymphocyte diameter and the fraction of lymphocytes containing nucleoli were both found to have an inverse correlation with survival. Bone‐marrow aspirate films were available for 64 patients. Differential leukocyte counts showed that the median for marrow lymphocytes was 64%. Those patients with a greater than median proportion of lymphocytes on marrow aspirate had a shorter survival time than those with less than median.
P1228 COMPARATIVE RESISTANCE ANALYSIS BETWEEN CIRRHOTIC AND NON-CIRRHOTIC TREATMENT EXPERIENCED PATIENTS WHO FAILED TREATMENT WITH A COMBINATION OF VANIPREVIR (MK-7009) AND PEGYLATED INTERFERON AND RIBAVIRIN (P/R)
Authors: S. Ludmerer, R. Barnard, J. Brunhoffer, A. Howe, P.M.T. Hwang, R. Liu, A. Zhou, N. Mobashery
Journal: Journal of Hepatology (2014)
Pus from the pylorus: an unusual endoscopic finding suggestive of periduodenal abscess
Authors: C. Chen, T. Lee, K. Liu, J. Lin, H. Wang
Journal: Endoscopy (2007)

Subphrenic intra-abdominal abscess is a well-documented complication of perforated duodenal ulcers [1] [2] [3] [4] [5]. We report here on an unusual endoscopic finding of a sutured perforated duodenal ulcer associated with a subphrenic abscess.