Gastric Secretory Failure in Patients with the Acquired Immunodeficiency Syndrome (AIDS)
Authors: Gerond Lake-Bakaar
Journal: Annals of Internal Medicine (1988)

Brief Reports15 September 1988Gastric Secretory Failure in Patients with the Acquired Immunodeficiency Syndrome (AIDS)Gerond Lake-Bakaar, MD, Elizabeth Quadros, PhD, Sary Beidas, MD, Magdy Elsakr, MD, Winston Tom, MD, Donald E. Wilson, MD, Hosoon P. Dincsoy, MD, Paul Cohen, MD, Eugene W. Straus, MDGerond Lake-Bakaar, MD, Elizabeth Quadros, PhD, Sary Beidas, MD, Magdy Elsakr, MD, Winston Tom, MD, Donald E. Wilson, MD, Hosoon P. Dincsoy, MD, Paul Cohen, MD, Eugene W. Straus, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-6-502 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe importance of gastric juice as a barrier to enteric infections has been well established (1, 2). The frequency of gastrointestinal infections and diarrhea in patients with the acquired immunodeficiency syndrome (AIDS) prompted us to study their gastric secretory function.Forty-eight patients diagnosed as having the acquired immunodeficiency syndrome according to criteria established by the Centers for Disease Control (3) were studied prospectively. The mean age of patients was 35 ± 9 years (mean ± 2 standard deviations [SD]). Thirty-six were men.Five healthy controls, three of whom were men, were recruited from the personnel at our institution. The mean...References1. GiannellaBroitmanZamcheck RSN. Influence of gastric acidity on bacterial and parasitic enteric infections: a perspective. Ann Intern Med. 1973;78:271-6. LinkGoogle Scholar2. HowdenHunt CR. Relationship between gastric secretion and infection. Gut. 1987;28:96-107. CrossrefMedlineGoogle Scholar3. Revision of the case definition of acquired immunodeficiency syndrome for national reporting-United States. MMWR. 1985;34:373-5. MedlineGoogle Scholar4. RaufmanSutliffKasbekarJensenGardner JVDRJ. Pepsinogen secretion from dispersed chief cells from guinea pig stomach. Am J Physiol. 1984;247(1 Pt 1):G95-104. MedlineGoogle Scholar5. RobozSuttajitBekesi JMJ. Elimination of 2-deoxyribose interference in the thiobarbituric acid determination of N-acetylneuraminic acid in tumor cells by pH-dependent extraction with cyclohexanone. Anal Biochem. 1981;110:380-8. CrossrefMedlineGoogle Scholar6. BudhrajaLevendogluKockaMangkornkanokSherer MHFMR. Duodenal mucosal T cell subpopulation and bacterial cultures in acquired immune deficiency syndrome. Am J Gastroenterol. 1987;82:427-31. MedlineGoogle Scholar7. Lake-BakaarWinstonLake-Bakaar GTD. Gastropathy and ketoconazole malabsorption in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1988;109:471-3. LinkGoogle Scholar8. TavitianRaufmanRosenthalWeberWebberDincsoy AJLJCH. Ketoconazole-resistant Candida esophagitis in patient with acquired immunodeficiency syndrome. Gastroenterology. 1986;90:443-5. CrossrefMedlineGoogle Scholar9. RobertsJamesJarvis SOE. Bacterial overgrowth syndrome without "blind loop": a cause for malnutrition in the elderly. Lancet. 1977;2:1193. CrossrefMedlineGoogle Scholar10. IrvineDaviesTeitelbaumDelamoreWilliams WSSIA. The clinical and pathological significance of gastric parietal cell antibody. Ann NY Acad Sci. 1965;124:657. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Gerond Lake-Bakaar, MD; Elizabeth Quadros, PhD; Sary Beidas, MD; Magdy Elsakr, MD; Winston Tom, MD; Donald E. Wilson, MD; Hosoon P. Dincsoy, MD; Paul Cohen, MD; Eugene W. Straus, MDFrom the State University of New York Health Science Center at Brooklyn, Brooklyn, New York. 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