Serum Homocysteine and Stroke in Atrial Fibrillation
Authors: Howard S. Friedman
Journal: Annals of Internal Medicine (2001)

Letters6 February 2001Serum Homocysteine and Stroke in Atrial FibrillationHoward S. Friedman, MDHoward S. Friedman, MDNew York University School of Medicine; New York, NY 10016 (Friedman)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-3-200102060-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Atrial fibrillation (AF) increases the risk for stroke (1). Although warfarin substantially decreases this risk (2), the need for frequent blood sampling to ensure efficacy and to monitor inherent risks of treatment, especially in elderly persons (3), are serious limitations. Cohort studies of AF have defined clinical subgroups with differing risks for stroke (2). However, no chemical predictor of stroke in AF has previously been reported. Elevated serum and plasma homocysteine concentrations have been identified as a risk factor for atherothrombotic diseases in general (4) and for stroke in particular (5). It would therefore be of interest ...References1. Wolf PA, Dawber TR, Thomas HE, Kannel WB. Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: the Framingham study. Neurology. 1979;28:973-7. CrossrefGoogle Scholar2. Prystowsky EN, Benson DW, Fuster V, Hart RG, Kay GN, Myerburg RJ, et al . Management of patients with atrial fibrillation. A Statement for Healthcare Professionals. From the Subcommittee on Electrocardiography and Electrophysiology, American Heart Association. Circulation. 1996;93:1262-77. CrossrefMedlineGoogle Scholar3. . Bleeding during antithrombotic therapy in patients with atrial fibrillation. The Stroke Prevention in Atrial Fibrillation Investigators. Arch Intern Med. 1996;156:409-16. CrossrefMedlineGoogle Scholar4. Hankey GJ, Eikelboom JW. Homocysteine and vascular disease. Lancet. 1999;354:407-13. CrossrefMedlineGoogle Scholar5. Bostom AG, Rosenberg IH, Silbershatz H, Jacques PF, Selhub J, D'Agostino RB, et al . Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: the Framingham Study. Ann Intern Med. 1999;131:352-5. LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Howard S. Friedman, MDAffiliations: New York University School of Medicine; New York, NY 10016 (Friedman) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNonfasting Plasma Total Homocysteine Levels and Stroke Incidence in Elderly Persons: The Framingham Study Andrew G. Bostom , Irwin H. Rosenberg , Halit Silbershatz , Paul F. Jacques , Jacob Selhub , Ralph B. D'Agostino , Peter W.F. Wilson , and Philip A. Wolf Metrics Cited byElevated homocysteine increases the risk of left atrial/left atrial appendage thrombus in non-valvular atrial fibrillation with low CHA2DS2-VASc scoreHomocysteine in non-valvular atrial fibrillation: Role and clinical implicationsMechanisms of thrombogenesis in atrial fibrillation – Authors' replyHyperhomocysteinemia as an Independent Risk Factor for Cardioembolic Stroke in the Turkish PopulationA Randomized Effectiveness Trial of a Clinical Informatics Consult Service: Impact on Evidence-based Decision-making and Knowledge ImplementationCulprit Factors for the Failure of Well-Conducted Warfarin Therapy to Prevent Ischemic Events in Patients With Atrial FibrillationHyperhomocysteinemia and vitamin B6 deficiency: New risk markers for nonvalvular atrial fibrillation?Homocysteine and the Risk of Stroke and Thromboembolism in Atrial Fibrillation: An Uncertain RoleHyperhomocysteinemia and Left Atrial Thrombus in a Stroke Patient With Sinus RhythmHyperhomocysteinemia Is Associated With the Presence of Left Atrial Thrombus in Stroke Patients With Nonvalvular Atrial FibrillationRole of homocysteine for thromboembolic complication in patients with non-valvular atrial fibrilation 6 February 2001Volume 134, Issue 3Page: 253-254KeywordsAtrial fibrillationAttentionCreatinineDiagnostic imagingElderlyImmunoassaysMedical risk factorsMyocardial infarctionStroke ePublished: 6 February 2001 Issue Published: 6 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...