tbuckley/cabot-search huggingface dataset:
Quality of life, health-state utilities and willingness to pay in patients with psoriasis and atopic eczema
Authors: L. Lundberg, M. Johannesson, M. Silverdahl, C. Hermansson, M. Lindberg
Journal: British Journal of Dermatology (1999)

Journal Article Quality of life, health‐state utilities and willingness to pay in patients with psoriasis and atopic eczema Get access L. Lundberg, L. Lundberg Department of Pharmacy, Pharmaceutical Services Research, BMC, Uppsala University, Box 586, 751 23 Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar M. Johannesson, M. Johannesson Centre for Health Economics, Stockholm School of Economics, Sweden Search for other works by this author on: Oxford Academic Google Scholar M. Silverdahl, M. Silverdahl Department of Medical Sciences, Dermato‐Venereology, Uppsala University, Sweden Search for other works by this author on: Oxford Academic Google Scholar C. Hermansson, C. Hermansson Department of Medical Sciences, Dermato‐Venereology, Uppsala University, Sweden Search for other works by this author on: Oxford Academic Google Scholar M. Lindberg M. Lindberg Department of Medical Sciences, Dermato‐Venereology, Uppsala University, Sweden Ms Lena Lundberg.E‐mail: lena.lundberg@samfarm.uu.se Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 6, 1 December 1999, Pages 1067–1075, https://doi.org/10.1046/j.1365-2133.1999.03207.x Published: 01 December 1999
Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents
Authors: Lawrence F. Eichenfield, Anne W. Lucky, Mark Boguniewiczc, Richard G.B. Langley, Robert Cherille, Katharine Marshalle, Christopher Bushe, Michael Graeber
Journal: Journal of the American Academy of Dermatology (2002)
Statin prescribing fell after drug became available over the counter
Authors: Roger Dobson
Journal: BMJ (2006)

The number of GPs' prescriptions of statins fell by 10% in the United Kingdom after low dose simvastatin was made available over the counter in August 2004.

Around 600 000 fewer statin prescriptions were issued in the second quarter of 2005 after the switch than would have been predicted by the previous trend, says a paper that assessed the effect of the policy change.

The authors of the paper, which was published online ahead of print publication on 5 September in Pharmacoepidemiology and Drug Safety (www3.interscience.wiley.com; doi: 10.1002/pds.1314), say that …
Probable Efficacy of High-Dose Salicylates in Reducing Coronary Involvement in Kawasaki Disease
Authors: Gideon Koren
Journal: JAMA (1985)

The efficacy of high-dose salicylates in reducing the coronary artery involvement of Kawasaki disease was compared in 36 children who received acetylsalicylic acid, 80 to 180 mg/kg/day, and in 18 who did not receive high-dose salicylates during the febrile phase of the disease and whose fever was controlled mainly with acetaminophen. The two groups were comparable with respect to age and body weight. In the acetylsalicylic acid-treated group, the dose was adjusted to meet the therapeutic serum concentration range (greater than or equal to 20 mg/dL). There were significantly more cases of coronary involvement in the nontreated group (50%) than in the salicylate-treated group (16.6%) and of coronary aneurysms (39% vs 3%). During the febrile phase of the disease, salicylate serum concentrations achieved with a given dose were on the average twofold lower than during the nonfebrile phase, owing to impaired absorption of acetylsalicylic acid. It is suggested that despite the difficulty in achieving therapeutic serum concentrations of salicylate during the febrile phase of Kawasaki disease with a dose as high as 100 mg/kg/day, this dose is potentially capable of preventing the associated coronary disease.
Radioisotope Bone Scanning in a Case of Sarcoidosis
Authors: DOROTHY C. CINTI, HAROLD B. HAWKINS, JAMES D. SLAVIN
Journal: Clinical Nuclear Medicine (1985)

The application of radioisotope scanning to osseous involvement from systemic sarcoidosis has been infrequently described in the scientific literature. Most commonly, the small bones of the hands and feet are affected if sarcoidosis involves the skeleton. Nonetheless, there are also occasional manifestations of sarcoid in the skull, long bones, and vertebral bodies. This paper describes a case of sarcoid involving the lung parenchyma with multiple lesions in the skull and ribs demonstrated by bone scanning with Tc-99m MDP. Following treatment with steroids, the bone scan showed complete resolution of the rib lesions and almost complete resolution of the lesions in the calvarium.
PERIODICITY OF GNAT BITES
Authors: Wm. O. Beddard
Journal: BMJ (1922)

_________________________________________________L MEDICAL JOURNAE.95 were issued and prophylactic lectures given from November 8th, 1917, to March 31st, 1918, and nearly 30,000 troops were on leave in Paris, the medical officer in charge stated that the venereal disease rate had been reduced to only 3 per cent., and that, " of this 3 per cent., it was ascertained by questioning the men personally that . . .one-third wanted to contract venereal disease because they preferred to be in hospital to being in the front line."2. American Troops.-Venerealdisease was quite well recognized as a self-inflicted disease among the Americani troops, and orders were issued warning officers to watch for "wilful infections"- sometimes sought for trivial reasons, such as obtaining a change of Command (vide iilanial oj Mllilitar?yUrolcgy, issued by American
MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury
Authors: Lars E. Schmidt, Fin Stolze Larsen
Journal: Hepatology (2007)

Abstract The Model for End-Stage Liver Disease (MELD) scoring system has been established as a reliable measure of short-term mortality risk in patients with end-stage chronic liver disease. The aim of this study was to evaluate the prognostic value of the MELD scoring as a predictor of fulminant hepatic failure (FHF) and death in patients with acetaminophen poisoning. Prospectively, serial measurements of the 3 MELD components—INR, bilirubin, and creatinine—were performed in 460 patients with acetaminophen-induced liver injury. Starting on the first day after the day of overdose, MELD score was significantly higher in patients who eventually developed hepatic encephalopathy (HE) than in those who did not. HE developed in 63 of 142 patients with a MELD score above 18 at 48-72 hours after the overdose (positive predictive value 44%) compared with 2 of 182 patients with a MELD score of 18 or below (negative predictive value 99%). Among 124 patients with FHF, a threshold MELD score of 33 on the day after the onset of HE had sensitivity of 60%, specificity of 69%, positive predictive value of 65%, and negative predictive value of 63%. However, the discriminative power of MELD score was not superior to that of INR alone or of the King's College Hospital criteria. Conclusion : MELD score may be useful as a predictor of FHF in patients admitted with acetaminophen toxicity. However, as a predictor of death from FHF, MELD score did not provide more information than the King's College Hospital criteria or INR alone. (Hepatology 2007;45:789–796.)
5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease
Authors: David Pertuit, Brice Moulari, Thomas Betz, Arulraj Nadaradjane, Dirk Neumann, Lhassane Ismaïli, Bernard Refouvelet, Yann Pellequer, Alf Lamprecht
Journal: Journal of Controlled Release (2007)
Prostaglandin endoperoxides modulate the response to thromboxane synthase inhibition during coronary thrombosis.
Authors: D J Fitzgerald, J Fragetta, G A FitzGerald
Journal: Journal of Clinical Investigation (1988)

Prostaglandin endoperoxides (PGG2/PGH2), precursors of thromboxane (TX) A2 and prostaglandins, may accumulate sufficiently in the presence of a TXA2 synthase inhibitor to exert biological activity. To address whether this modulates the response to TXA2 synthase inhibition in the setting of thrombosis in vivo, we examined the interaction of a TXA2 synthase inhibitor (U63,557a) and a TXA2/prostaglandin endoperoxide receptor antagonist (L636,499) in a canine model of coronary thrombosis after electrically induced endothelial injury. U63,557a exerted little inhibitory effect in this model despite a marked reduction in serum TXB2 and urinary 2,3-dinor-TXB2, an index of TXA2 biosynthesis. Combination of the two drugs was more effective than either drug alone. The enhanced effect achieved upon addition of the TXA2/prostaglandin endoperoxide receptor antagonist to the TXA2 synthase inhibitor suggests that the response to the latter compound was limited by the proaggregatory effects of prostaglandin endoperoxides. The increased effect of the combination over the receptor antagonist alone may reflect metabolism of PGG2/PGH2 to platelet inhibitory prostaglandins. This is supported by the following findings: (a) urinary 2,3-dinor-6-keto-PGF1 alpha, an index of prostacyclin biosynthesis, increased after administration of the synthase inhibitor, an effect that was exaggerated in the presence of thrombosis; (b) inhibition of arachidonate-induced platelet aggregation by U63,557a was dependent on the formation of a platelet-inhibitory prostaglandin; and (c) pretreatment with aspirin abolished the synergism between these compounds. These studies demonstrate that prostaglandin endoperoxides modulate the response to TXA2 synthase inhibition in vivo and identify a drug combination of potential therapeutic efficacy in the prevention of thrombosis.
Sarcoidosis and Sickle Cell Disease
Authors: Gairy Hall
Journal: Annals of Internal Medicine (1993)

Letters15 January 1993Sarcoidosis and Sickle Cell DiseaseGairy Hall, MD and Jerome Carter, MDGairy Hall, MD and Jerome Carter, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-2-199301150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A few patients with sarcoidosis and hemoglobinopathies have been reported, but only four have been associated with sickle cell disease [1-4]. We describe a patient with sarcoidosis, sickle cell anemia, and persistent thrombocytosis. A 36-year-old black woman with sickle cell anemia was hospitalized with painful sickle cell crisis. Over the preceding months, she had multiple admissions to another hospital because of joint pains, fevers, malaise, and fatigue. Her vital signs and physical examination were normal except for joint tenderness. Her hematocrit was 17%, her platelet count was 1200 × 10 (3/mm)3, and a corrected leukocyte count was ...References1. Haut M, Cowan O, Harris J. Platelet function and survival in sickle cell disease. J Lab Clin Med. 1973; 82:44-52. Google Scholar2. Greenberg S, Atwater J, Isreal H. Frequency of hemoglobinopathies in sarcoidosis. Ann Intern Med. 1965; 62:125-8. Google Scholar3. Hirschman R, Johns C. Hemoglobin studies in sarcoidosis. Ann Intern Med. 1965; 62:129-32. Google Scholar4. Madigan J, Gragoudas E, Schwartz P, Lapus J. Peripheral retinal neovascularization in sarcoidosis and sickle cell anemia. Am J Ophthalmol. 1977; 83:387-91. Google Scholar5. Young R, Castro O, Baxter R, Dunn R, Armstrong E, Cook F, et al. The lung in sickle cell disease: a clinical overview of common vascular, infectious, and other problems. J Nat Med Assoc. 1981; 73:19-26. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMycobacterium Avium Complex Presenting as Pulmonary Nodules in a Child With Sickle Cell DiseaseCoexisting Sickle Cell Anemia and Sarcoidosis: A Management Conundrum!SARCOIDOSIS PRESENTING WITH MASSIVE SPLENOMEGALY IN A CHILD WITH A HISTORY OF IRIDOCYCLITIS AND SENSORINEURAL DEAFNESSSickle cell disease, pulmonary hypertension, and sarcoidosisRare Forms of Sarcoidosis 15 January 1993Volume 118, Issue 2Page: 157-158KeywordsAnemiaFeversHemoglobinopathiesPlateletsPulmonary diseasesSarcoidosisSickle cell diseaseThoraxThrombocytosisVital signs Issue Published: 15 January 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Thromboplastic and Fibrinolytic Activity of the Human Aorta
Authors: TAGE ASTRUP, OLE K. ALBRECHTSEN, MARYLIN CLAASSEN, JORGEN RASMUSSEN
Journal: Circulation Research (1959)

In the thrombogenic theory of the pathogenesis of arteriosclerotic lesions, parietal fibrin deposits in the arteries play a primary role. In an effort to elucidate the hemostatic system in the arterial wall, the thromboplastic activity and the fibrinolytic activity (estimated as plasminogen activator) in the layers of the human aorta have been estimated. The simultaneous presence of high thromboplastic activity and little or no fibrinolytic activity found in the intima and the media suggest that fibrin can easily he deposited after tissue injury and that its eventual removal depends upon the humoral fibrinolytic system in the circulating blood. The observations apparently support the thrombogenic theory.
Falling quality of caring mirrors the rise of materialism
Authors: M H M Harrison
Journal: BMJ (1995)

Cases of metastatic placental site trophoblastic tumor (PSTT) have a very poor prognosis because these tumors tend to be less sensitive to chemotherapy than other types of gestational trophoblastic disease. We describe the case of a 25-year-old woman who presented with occipital tumor and abnormal vaginal bleeding. Hysterectomy, bilateral salpingo-oophorectomy, and occipital tumor removal revealed a primary PSTT in the uterus, with ovarian and occipital subaponeurotic metastases. She received etoposide, methotrexate, actinomycin-D/cyclophosphamide, vincristine chemotherapy and had a complete clinical remission. Fifteen months later, she had a recurrent subaponeurotic occipital tumor invading the cranium and underwent tumor removal along with cranial bone followed by local irradiation. She was then treated with etoposide, cis-platinum/etoposide, methotrexate, actinomycin-D chemotherapy and again had a remission for 5 months. The patient, however, had a left parietal subaponeurotic tumor, invading the dura mater, and received local irradiation. Soon after, she developed left orbital bone metastasis, treated by local irradiation. These bone metastases responded to the radiation completely. However, multiple organ metastases were found, and she died of the disease. This represents the first case of PSTT with initial subaponeurotic metastasis in a living patient. New modalities of treatment for high-risk or metastatic PSTT need to be developed
Bone marrow–derived stem cells preserve cone vision in retinitis pigmentosa
Authors: Lois E.H. Smith
Journal: Journal of Clinical Investigation (2004)

Retinitis pigmentosa is a heritable group of blinding diseases resulting from loss of photoreceptors, primarily rods and secondarily cones, that mediate central vision. Loss of retinal vasculature is a presumed metabolic consequence of photoreceptor degeneration. A new study shows that autologous bone marrow–derived lineage-negative hematopoietic stem cells, which incorporate into the degenerating blood vessels in two murine models of retinitis pigmentosa, rd1 and rd10, prevent cone loss. The use of autologous bone marrow might avoid problems with rejection while preserving central cone vision in a wide variety of genetically disparate retinal degenerative diseases.
Floating Islets in Strange Seas
Authors: Samuel Vaisrub
Journal: JAMA (1975)

A transplanted organ is rarely a complete replacement for the original, if only because it is denervated—a fact often ignored by "sci-fi" writers who will transplant a brain with blatant nonchalance at the bat of an eyelash. Still, incomplete as it is, the grafted organ often functions satisfactorily. This is the case with the renal transplant in which the absence of modulation by the autonomic nervous system does not interfere seriously with performance. Such may also be the case with the cardiac transplant that can function, albeit not optimally, without this modulation. Success or failure of an engraftment depends less on the integrity of the transplant than on histocompatibility, immunosuppression, infection, and persistence of the original disease—factors that present obstacles that are challenging, but not necessarily unsurmountable. An added factor in some transplants—notably those of the bone marrow—is the graft-vs-host reaction. This immunologic assault, mounted by the grafted tissue against
1055 SEQUENCE EVOLUTION OF THE HCV NS3/4A PROTEASE DURING ACUTE HEPATITIS C VIRUS (HCV) INFECTION
Authors: J. Dietz, T. Lutz, G. Knecht, P. Gute, A. Nehring, B. Raziorrouh, H. Diepolder, S. Zeuzem, C. Sarrazin
Journal: Journal of Hepatology (2010)
Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function
Authors: Yu-Tzu Tai, Holly M. Horton, Sun-Young Kong, Erik Pong, Hsing Chen, Saso Cemerski, Matthew J. Bernett, Duc-Hanh T. Nguyen, Sher Karki, Seung Y. Chu, Greg A. Lazar, Nikhil C. Munshi, John R. Desjarlais, Kenneth C. Anderson, Umesh S. Muchhal
Journal: Blood (2012)

HM1.24, an immunologic target for multiple myeloma (MM) cells, has not been effectively targeted with therapeutic monoclonal antibodies (mAbs). In this study, we investigated in vitro and in vivo anti-MM activities of XmAb5592, a humanized anti-HM1.24 mAb with Fc-domain engineered to significantly enhance FcγR binding and associated immune effector functions. XmAb5592 increased antibody-dependent cellular cytotoxicity (ADCC) several fold relative to the anti-HM1.24 IgG1 analog against both MM cell lines and primary patient myeloma cells. XmAb5592 also augmented antibody dependent cellular phagocytosis (ADCP) by macrophages. Natural killer (NK) cells became more activated by XmAb5592 than the IgG1 analog, evidenced by increased cell surface expression of granzyme B-dependent CD107a and MM cell lysis, even in the presence of bone marrow stromal cells. XmAb5592 potently inhibited tumor growth in mice bearing human MM xenografts via FcγR-dependent mechanisms, and was significantly more effective than the IgG1 analog. Lenalidomide synergistically enhanced in vitro ADCC against MM cells and in vivo tumor inhibition induced by XmAb5592. A single dose of 20 mg/kg XmAb5592 effectively depleted both blood and bone marrow plasma cells in cynomolgus monkeys. These results support clinical development of XmAb5592, both as a monotherapy and in combination with lenalidomide, to improve patient outcome of MM.
Anticholinergics for Patients with Asthma?
Authors: Lewis J. Smith
Journal: New England Journal of Medicine (2010)

Current guidelines for treating patients with asthma whose symptoms are not controlled by a low dose of an inhaled glucocorticoid alone recommend either doubling the glucocorticoid dose or adding a long-acting beta-agonist (LABA).1 However, inhaled glucocorticoids have a relatively flat dose–response curve, so doubling the dose may result in little or no improvement in individual patients.2 LABAs are generally more effective,1,3 but an increased concern about infrequent but life-threatening exacerbations4 has reduced enthusiasm for the use of these drugs. Alternatives to the addition of LABA therapy include high doses of inhaled glucocorticoids, leukotriene modifiers, theophylline, anti-IgE therapy for selected . . .
Culmination of an Era in Research on the Acute Respiratory Distress Syndrome
Authors: Martin J. Tobin
Journal: New England Journal of Medicine (2000)

The acute respiratory distress syndrome is a form of noncardiogenic pulmonary edema that results from acute damage to the alveoli. Most patients with this syndrome will die if they do not receive supplemental oxygen and assisted ventilation. By reversing life-threatening hypoxemia and alleviating the work of breathing, mechanical ventilation buys time for the lungs to heal. Mechanical ventilation can also cause lung damage by several mechanisms, including alveolar rupture and alveolar hemorrhage, especially when high airway pressures are used for ventilation.Initially, the diffuse shadows seen on chest x-ray films in patients with the acute respiratory distress syndrome led clinicians . . .
Reviewing Potential Malpractice Cases-Reply
Authors: Ilene Johnson
Journal: JAMA (1992)

<h3>In Reply.</h3> —Plaintiffs whose attorneys retain Dr Coyle to review an alleged medical liability case are indeed fortunate, as Dr Coyle's approach takes into account the costs that must be borne by those plaintiffs to retain an expert witness to review a claim, even where it is determined that liability does not exist. However, Dr Coyle's letter raises an important problem inherent in the current civil justice system—that of access to the system and the attendant costs of access. Plaintiffs' attorneys must hire costly medical experts to review cases and to testify in court in support of the plaintiffs allegations. Those plaintiffs who have lesser amounts of damages often cannot find an attorney to represent them, because any anticipated payment, whether by way of settlement or verdict, will be insufficient to yield an adequate contingency fee for the plaintiffs attorney and to cover the high costs of expert witness(es). In
Management of pulmonary aspergilloma in the presence of active tuberculosis.
Authors: A O Adeyemo, E O Odelowo, D I Makanjuola
Journal: Thorax (1984)

Eleven cases of pulmonary aspergilloma complicating active cavitating pulmonary tuberculosis are reviewed. Nine of the 10 patients who had combined medical (antituberculosis drugs) and surgical treatment were cured of their disease; one patient, who had bilateral multiple aspergillomas, died from massive haemoptysis after resection of one of the affected lobes. The only medically treated patient who refused surgery had fatal haemoptysis at home. Pulmonary resection is recommended for patients who are fit for operation whenever the diagnosis of aspergilloma is made because most published reports indicate that only a few patients benefit from drug treatment alone.
Engineers, Cranks, Physicians, Magicians
Authors: Clark Glymour, Douglas Stalker
Journal: New England Journal of Medicine (1983)

Medicine in industrialized nations is scientific medicine. The claim tacitly made by American or European physicians, and tacitly relied on by their patients, is that their palliatives and procedures have been shown by science to be effective. Although the physician's medical practice is not itself science, it is based on science and on training that is supposed to teach physicians to apply scientific knowledge to people in a rational way.The practice of medicine in the United States and in other industrialized nations is a form of consultant engineering. The subjects are people rather than bridges, but in many respects . . .