tbuckley/cabot-search huggingface dataset:
Metabolic Effects of Diuretic and Nondiuretic Benzothiadiazines.
Authors: William R. Wilson
Journal: Annals of Internal Medicine (1964)

s1 February 1964Metabolic Effects of Diuretic and Nondiuretic Benzothiadiazines.William R. Wilson, M.D., F.A.C.P., Daniel B. Stone, M.D., Ronald Okun, M.D., R. Patterson Russell, M.D.William R. Wilson, M.D., F.A.C.P.Search for more papers by this author, Daniel B. Stone, M.D.Search for more papers by this author, Ronald Okun, M.D.Search for more papers by this author, R. Patterson Russell, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-317_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA double-blind study of the metabolic effects of trichlormethiazide (TCZ) and diazoxide was performed in 45 hypertensive patients. Each patient received TCZ, 8 mg/day for 3 weeks, then was randomly allocated to one of three groups for 4 weeks. Fifteen patients received TCZ, 8 mg/day (group I); 15 patients received TCZ, 8 mg plus diazoxide, 200 mg, daily (group II); 15 patients received TCZ, 8 mg plus diazoxide, 400 mg, daily (group III). Two-hour postprandial blood sugars (PPBS), serum urea nitrogen (SUN) and serum uric acid (SUA) were measured before and after the trial."Thiazide hyperglycemia" developed in 17 patients;... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: William R. Wilson, M.D., F.A.C.P.; Daniel B. Stone, M.D.; Ronald Okun, M.D.; R. Patterson Russell, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUntersuchungen zur Fettstoffwechselstörung durch SaluretikaDer experimentelle DiabetesDiskussionsbemerkung zu der ArbeitA structural basis for the hyperglycemic action of diuretics?Thiazide Diuretics and Related DrugsUntersuchungen zur Frage einer Wechselwirkung von saluretisch wirksamen Thiazidderivaten und Thiamin bei DiabetikernDIAZOXIDE AND THE TREATMENT OF HYPOGLYCEMIA: AN HISTORICAL REVIEWMECHANISM OF DIAZOXIDE HYPERGLYCEMIA IN ANIMALSUntersuchungen zur Beeinflussung des Kohlenhydratstoffwechsels durch saluretisch wirksame Thiazidderivate und ThiaminON THE ACTION OF BENZOTHIADIAZINES AND RELATED COMPOUNDS ON ENZYMIC AND HORMONAL REGULATION OF CARBOHYDRATE METABOLISM**This study was supported by the Deutsche Forschungsgemeinschaft.Diazoxide blood levels in manThe effect of diazoxide on catecholaminesPharmacology of diureticsPharmacology of diureticsBiochemische Grundlagen der Diazoxid-Hyperglyk�mieDer Einflu� von Hydrochlorothiazid auf die blutzuckersteigernde Wirkung des DiazoxidsThe effect of diazoxide and chlorothiazide on glucose uptake in vitroDrug-induced Diabetes 1 February 1964Volume 60, Issue 2_Part_1Page: 317-317KeywordsBlood sugarDiureticsHyperglycemiaSerum urea nitrogenUric acid ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...
Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors
Authors: Markus Juonala, Costan G. Magnussen, Gerald S. Berenson, Alison Venn, Trudy L. Burns, Matthew A. Sabin, Sathanur R. Srinivasan, Stephen R. Daniels, Patricia H. Davis, Wei Chen, Cong Sun, Michael Cheung, Jorma S.A. Viikari, Terence Dwyer, Olli T. Raitakari
Journal: New England Journal of Medicine (2011)

Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults.
Abnormal gastric adaptive relaxation in patients with gastrooesophageal reflux.
Authors: M N Hartley, S J Walker, C R Mackie
Journal: Gut (1990)

Gastric adaptive relaxation was measured in 15 healthy volunteers (control group) and in 12 patients with symptomatic gastrooesophageal reflux confirmed by 24 hour pH monitoring (reflux group). The control group were: 13 men, two women; median age 30 years, range 22-41; median body weight 70 kg, range 50-79 kg. All were asymptomatic on no medication. The reflux group were: eight men, four women, median age 48 years, range 23-65; median body weight 77 kg, range 60-92 kg. Medication was withheld for 12 hours before the study. Endoscopy showed no abnormality in five patients, oesophagitis in three patients and oesophagitis with hiatus hernia in four patients. Fasted subjects were intubated with a Ryle9s tube containing a pressure microtransducer within a flaccid plastic bag (800 ml). Gastric corpus-fundus pressure was recorded during distension of the bag with 460 (20) ml mean (SD) of air over 30 seconds. Pressure indices (median: range) derived from areas under the pressure curves during distension were: control: 12.7 (7.5-17.1) cm H2O; reflux: 9.1 (6.4-13.3) cm H2O, p less than 0.01 (Mann Whitney U test). Similar results were obtained from pressure indices derived from recordings during the immediate postdistension period. No correlation was found between pressure indices and age, sex or body weight. The results indicate that the gastric pressure response to distension is reduced in patients with gastrooesophageal reflux.
The sour taste of aid snobbery
Authors: Daniel Magnus
Journal: BMJ (2006)

I n western Kenya in the middle of July a team of 20 British doctors and nurses, predominantly from Bath, ran a series of free medical camps in one of the most impoverished areas in the country. The people came in enormous numbers. Some people came with little wrong at all but excited at the chance to see a doctor instead of the long and unaffordable journey to the nearest government facility to pay for suffocating bureaucracy and a bed to share with two other people. Many others came with the predictable and tragic array of subSaharan diseases in an area with endemic malaria and poverty and an HIV/AIDS prevalence of 25%. In total, the team and the Kenyan staff with whom they were working saw 14 000 patients.

The clinical visit was organised by the Kenyan Orphan Project—a small group started by two medical student friends and myself that, for the past five years, has been helping with health, …
964 INCIDENCE OF VIROLOGIC ESCAPE OBSERVED DURING ITMN-191 (R7227) MONOTHERAPY IS GENOTYPE DEPENDENT, ASSOCIATED WITH A SPECIFIC NS3 SUBSTITUTION, AND SUPPRESSED UPON COMBINATION WITH PEGINTERFERON ALFA-2A/RIBAVIRIN
Authors: C. Sarrazin, J. Hong, S. Lim, X. Qin, S. Susser, B. Bradford, S. Porter, S. Zeuzem, S. Seiwert
Journal: Journal of Hepatology (2009)
ECOG Phase II Trial of Graded-Dose Peginterferon α-2b in Patients with Metastatic Melanoma Overexpressing Basic Fibroblast Growth Factor (E2602)
Authors: Ronald S. Go, Sandra J. Lee, Donghoon Shin, Steven M. Callister, Dean A. Jobe, Robert M. Conry, Ahmad A. Tarhini, John M. Kirkwood
Journal: Clinical Cancer Research (2013)

Abstract Purpose: We investigated the use of graded-dose peginterferon α-2b (Peg-IFN) in patients with stage IV melanoma overexpressing basic fibroblast growth factor (FGF-2). The primary objective was suppression of plasma FGF-2 to within reference range (≤7.5 pg/mL). Experimental Design: Plasma FGF-2 was measured at baseline (step 1), and patients with concentrations of 15 pg/mL or more were eligible for study treatment (step 2). Peg-IFN was given weekly at a starting dose of 0.5 μg/kg/wk with increment every 3 weeks based on serial FGF-2 concentrations. Results: Two hundred seven patients entered step 1; 45 (22%) overexpressed FGF-2 (median = 22 pg/dL). Twenty-nine eligible patients entered step 2 and received treatment. Patients' median age was 64 years (range, 29–84 years). Most had more than two prior therapies. FGF-2 decreased in 28 (97%) patients, with suppression to reference range in 10 (35%). Median time to FGF-2 suppression was 30 days. The best clinical responses were partial response (7%) and stable disease (17%). Median progression-free survival (PFS) and overall survival (OS) were 2.0 and 9.7 months, respectively. Patients who achieved FGF-2 suppression were more likely than those who did not to have a response or stable disease (P = 0.03). VEGF concentrations decreased in 27 patients (93%) during treatment and paralleled those of FGF-2 over time. We found no compensatory increase in VEGF among those with FGF-2 suppression. Conclusions: Graded-dose Peg-IFN suppresses FGF-2 in patients with metastatic melanoma who overexpress FGF-2. Over one third of patients had complete suppression of plasma FGF-2, which correlated with clinical response to this therapy. Clin Cancer Res; 19(23); 6597–604. ©2013 AACR.
Online Disclosure of Physician–Industry Relationships
Authors: Robert Steinbrook
Journal: New England Journal of Medicine (2009)

The Cleveland Clinic and some of its leading physicians have been criticized for their financial associations with industry and the limited disclosure of these relationships to patients and the public. In response, the medical center has strengthened its policies and oversight with regard to conflicts of interest and required that all industry relationships be submitted for approval. Since December 2008, it has also disclosed on its Web site (www.clevelandclinic.org) some of the industry ties of its 2000 physicians and researchers and their immediate families.1 The posting of physicians' financial information by a leading academic medical center, along with continuing revelations . . .
Glycated albumin as a diagnostic tool for diabetes in a general Japanese population
Authors: Hiroaki Ikezaki, Norihiro Furusyo, Takeshi Ihara, Takeo Hayashi, Kazuya Ura, Satoshi Hiramine, Fujiko Mitsumoto, Koji Takayama, Masayuki Murata, Takuji Kohzuma, Masumi Ai, Ernst J. Schaefer, Jun Hayashi
Journal: Metabolism (2015)
AIDS in Haiku City
Authors: B. A. St Andrews
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute promyelocytic leukemia after treatment for non-Hodgkin's lymphoma with drugs targeting topoisomerase II
Authors: A. De Renzo, L.F.E. Santoro, R. Notaro, F. Pane, M.R. Buonaiuto, L. Luciano, B. Rotoli
Journal: American Journal of Hematology (1999)

We report a patient who developed acute promyelocytic leukemia (APL) concomitantly with a second relapse of non-Hodgkin's lymphoma (NHL), intermediate grade, WF type E. At diagnosis and at first NHL relapse, the patient had received the same chemotherapy regimen, which included drugs targeting DNA topoisomerase II, i.e., etoposide (total dose 5,760 mg) and idarubicin (total dose 180 mg). Thirty-eight months after initial treatment, the patient showed pancytopenia associated with lymphoma recurrence. Bone marrow examination revealed the presence of atypical promyelocytes with Auer rods; cytogenetics showed t(15;17), and molecular analysis detected promyelocytic leukemia-retinoic acid receptor alpha rearrangement. APL reached complete remission after all trans retinoic acid therapy, whereas NHL did not respond to further chemotherapy. In the literature, five other patients developed APL after treatment for lymphoma, from a total of 59 patients developing sAPL after treatment for any type of neoplasia.
Is the Xylose Test still a Worth-while Investigation?
Authors: G. E. Sladen, P. J. Kumar
Journal: BMJ (1973)

In a retrospective survey the results of a D-xylose absorption test have been assessed in relation to jejunal morphology and final diagnosis in 152 adult patients with various types of gastrointestinal disease. Neither urine excretion rates nor serum concentrations alone provide an adequate separation between patients with definite mucosal lesions and those without evidence of gut disease or with other types of gastrointestinal pathology.It is suggested that when a jejunal biopsy can readily be performed the xylose test serves little useful purpose in routine practice and can be positively misleading. It may still be useful as a screening test for referral for jejunal biopsy, provided that strict criteria of normality are applied.
Increased Virus Shedding With Aspirin Treatment of Rhinovirus Infection
Authors: Edith D. Stanley
Journal: JAMA (1975)

In two double-blind trials, volunteers challenged with rhinovirus were treated with aspirin or placebo. Aspirin treatment did not alter the rates of infection or illness but was associated with a moderate reduction in the frequency or severity of some symptoms. The overall benefit in rhinovirus infection was not statistically significant. Aspirin treatment appeared to cause a highly significant increase in the rate of virus shedding in treated subjects. The increase in virus shedding must be considered an adverse event that could influence the course of the disease in the individual and increase the likelihood of the spread of the infection to contacts.
THE TECHNIC OF APPENDECTOMY.
Authors: JOHN A. WYETH
Journal: JAMA (1907)

I deem it my duty to acknowledge before this scientific body the obligation under which all mankind, professional or non-professional, has been placed by that brilliant galaxy of men who were the pioneers in the establishment of this great operation. To Kroenlein, who in 1884 did the first appendectomy, 1 placing a double ligature (material not stated) on the base of the appendix, which was removed, with fatal result; 2 to Dr. Reginald H. Fitz, of Boston, who in 1886 published his classical article on this subject; to the late Dr. Richard Hall, of New York, who in May, 1886, in that city, did a successful appendectomy, ligating the stump with a catgut ligature; to the late Prof. T. G. Morton, of Philadelphia, who operated on the first case for which the diagnosis had been made and operation done with the intention of removing the appendix, in which the stump
Reducing the incidence of infection after caesarean section: implications of prophylaxis with antibiotics for hospital resources.
Authors: M. Mugford, J. Kingston, I. Chalmers
Journal: BMJ (1989)

OBJECTIVES--To estimate the cost effectiveness of giving prophylactic antibiotics routinely to reduce the incidence of wound infection after caesarean section. DESIGN--Estimation of cost effectiveness was based, firstly, on a retrospective overview of 58 controlled trials and, secondly, on evidence about costs derived from data and observations of practice. SETTING--Trials included in the overview were from obstetric units in several different countries, including the United Kingdom. The costing study was based on data referring to the John Radcliffe Maternity Hospital, Oxford. SUBJECTS--A total of 7777 women were included in the 58 controlled trials comparing the effects of giving routine prophylactic antibiotics at caesarean section with either treatment with a placebo or no treatment. Cost estimates were based on data on 486 women who had caesarean sections between January and September 1987. MAIN OUTCOME MEASURE--Cost effectiveness of prophylaxis with antibiotics. RESULTS--The odds of wound infection are likely to be reduced by between about 50 and 70% by giving antibiotics routinely at caesarean section. Forty one (8.4%) women who had caesarean section were coded by the Oxford obstetric data system as having developed wound infection. The additional average cost of hospital postnatal care for women with wound infection (compared with women who had had caesarean section and no wound infection) was estimated to be 716 pounds; introducing routine prophylaxis with antibiotics would reduce average costs of postnatal care by between 1300 pounds and 3900/100 pounds caesarean sections (at 1988 prices), depending on the cost of the antibiotic used and its effectiveness. CONCLUSIONS--The results suggest that giving antibiotics routinely at caesarean section will not only reduce rates of infection after caesarean section but also reduce costs.
Equivalent Inhibition by Terbutaline of Anti‐Human IgE Skin Responses in Atopic and Non‐Atopic Subjects
Authors: R. GRÖNNEBERG, K. STRANDBERG, G. STÅLENHEIM, O. ZETTERSTRÖM
Journal: Allergy (1985)

Previous studies have shown that pretreatment of skin with beta 2 ‐adrenoceptor stimulants antagonizes anti‐human IgE elicited wheal and flare reactions in atopic and non‐atopic subjects. This experimental system was employed to further study the hypothesis that atopic disease and bronchial asthma unrelated to atopy might be associated with a beta‐adrenoceptor defect. Eight patients with extrinsic and 10 patients with intrinsic asthma deprived of oral bronchodilator treatment and corticosteroids for at least a week, and in a clinically stable condition, 10 patients with extrinsic rhinitis and on no treatment, as well as age and sex matched healthy control subjects showed almost identical dose‐response relations for the inhibitory effect of intradermally injected terbutaline (0.25–100 ng), on anti‐IgE elicited skin reactions. In four asthmatic patients the inhibitory effect of terbutaline did not change following a treatment period with oral terbutaline and theophylline. The data do not support the presence of a cutaneous mast cell beta 2 ‐adrenoceptor defect in patients with atopy or bronchial asthma unrelated to atopy.
Lipid Profiles in Women With 45,X vs 46,XX Primary Ovarian Failure
Authors: M. Cooley
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphocyte Reactivity in Hodgkin's Disease: A Lymphocyte Civil War
Authors: Vincent T. DeVita
Journal: New England Journal of Medicine (1973)

Lymphocyte reactivity in Hodgkin's disease has plagued clinicians for many years. Adenopathy occurs from reactive follicular hyperplasia in nodes around tumor and accounts for many negative biopsies in patients ultimately proved to have the disease. Falsely positive lymphograms and splenomegaly without evidence of tumor invasion are relatively common occurrences that have been re-emphasized in many recent studies employing laparotomy for staging the disease. Reactive lymphoid changes were also noted by Crowther et al.1 in 1967, when they described lymphoblastoid cells unresponsive to phytohemagglutinin (PHA) in the peripheral blood of patients with Hodgkin's disease. Now Longmire et al., in this issue . . .
Antenatal care on trial
Authors: J. Neilson
Journal: BMJ (1996)

There are at least 13 randomised controlled trials of assertive community treatment in the world literature, 12 of which have found the approach beneficial when compared with routine management.There are at least nine randomised controlled trials of standard case management and two well designed non-randomised controlled studies, all but one of which have largely negative findings.Curiously, the whole thrust of community care policy in Britain is towards the implementation of standard case management by another name.
P25 15 year retrospective study of non-tuberculous mycobacteria (NTM) isolates
Authors: AJ Scadding, C Ohri, N Perera, G Woltmann
Journal: Thorax (2012)

<h3>Introduction</h3> The incidence non-tuberculous mycobacteria (NTM) has been growing steadily and was previously estimated between 2.9–4.43/100,000 persons. 125 NTM species have been identified due to advances in laboratory techniques with a corresponding increase of clinical presentations. Treatment is recommended if the same species is cultured on at least 2 occasions with clinical/radiological evidence for progression. Other than cystic fibrosis predisposing factors in adults include chronic lung disease, immunodeficiency, gastro-oesophageal reflux disease and post-menopausal non-smoking females.[1] <h3>Methods</h3> 768 isolates were collected over 15 years in our regional mycobacterial database and analysed for demographic and frequency distributions using simple statistics. The data includes many single, incidental isolates as well as patients with multiple isolates and on-going symptoms. <h3>Results</h3> We analysed 768 non-tuberculous mycobacterial cultures from 534 patients. The mean age for first positive culture was 55 (range 0–102) with 42.7% of the isolates occurring above age 65. 58% (310) of subjects were male, 61.3% were white Caucasian and 24.5% were of South Asian ethnicity. 81.4% of isolates were single with only 2% of patients culturing more than 4 isolates. The patient with most isolates (12) grew Mycobacterium Avium Complex (MAC) repeatedly over a 10-year time span. The most common isolate was MAC (37.0%) followed by the rapidly growing mycobacteria (RGM) which accounted for 28.4%. In descending order M. Kansasii, M. Gordonae and M. Xenopi accounted for 8.7%, 6.9% and 3.9% of the isolates respectively. The majority of cultures were of respiratory origin from sputum (76.2%) and broncho-alveolar lavage (7%) samples. 3.8% of samples were cultured from pus, 1.3% from blood cultures and 0.7% from lymph nodes. <h3>Discussion</h3> In keeping with previous studies MAC was the most commonly identified mycobacterium and the most common population were older, white peoples. Our data for culture site compares to that published by the American Centers for Disease Control and Prevention. Our data highlights that a variety of NTM can be isolated from multiple locations and pose a diagnostic challenge. DE Griffith et al., “An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases,” <i>AJRCCM</i> 175, no.4 (February 2007): 367–416.
Will expansion of the NHS abroad benefit UK patients? Yes
Authors: P. Leonard
Journal: BMJ (2012)

The new NHS mandate calls for hospitals to set up more profit making branches abroad. <b>Philip Leonard</b> says this will bring new revenue to the cash strapped service, but <b>Allyson Pollock</b> (doi:10.1136/bmj.e8496) says that promoting trade in healthcare over universal access benefits no one