tbuckley/cabot-search huggingface dataset:
Erythropoietin increases cytosolic free calcium concentration in vascular smooth muscle cells
Authors: M. Neusser, M. Tepel, W. Zidek
Journal: Cardiovascular Research (1993)

Journal Article Erythropoietin increases cytosolic free calcium concentration in vascular smooth muscle cells Get access Marcus Neusser, Marcus Neusser Med Univ-Poliklinik, Albert-Schweitzer-Strasse 33, W-4400 Münster, Germany: M Neusser, M Tepel, W Zidek. Correspondence to Dr Zidek. Search for other works by this author on: Oxford Academic PubMed Google Scholar Martin Tepel, Martin Tepel Med Univ-Poliklinik, Albert-Schweitzer-Strasse 33, W-4400 Münster, Germany: M Neusser, M Tepel, W Zidek. Search for other works by this author on: Oxford Academic PubMed Google Scholar Walter Zidek Walter Zidek Med Univ-Poliklinik, Albert-Schweitzer-Strasse 33, W-4400 Münster, Germany: M Neusser, M Tepel, W Zidek. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 7, July 1993, Pages 1233–1236, https://doi.org/10.1093/cvr/27.7.1233 Published: 01 July 1993 Article history Received: 10 September 1992 Accepted: 02 February 1993 Published: 01 July 1993
Attempted Suicide, Depression and Physical Diseases: A 1-Year Follow-Up Study
Authors: E.N. Stenager, E. Stenager, K. Jensen
Journal: Psychotherapy and Psychosomatics (1994)

In the period January 1, 1990 to March 31, 1991 a sample of suicide attempters admitted to the Department of Psychiatry, Odense University Hospital, underwent a structured interview. In the study 52% of the patients interviewed were found to suffer from a somatic disease, and 21% were daily on analgesics for pain. Patients that suffered from a somatic disease differed from other suicide attempters in depression score, age, pain and the presence of psychosis. Fewer of the somatically ill suicide attempters had a psychosis. Patients complaining of pain were more often depressed and abused medicine. Statistically, the risk of repetition of parasuicide for patients with a somatic disease but without depression was significantly less. The 7 patients committing suicide were older and a tendency was found towards painful somatic diseases and depression as risk factors for suicide.
Expression of endoprotease furin, prohormone convertase (PC) 1/3 and PC2 in pulmonary neuroendocrine lesions: Correlation of functional differentiation of neuroendocrine cells with posttranslational processing of prohormones
Authors: Hiroshi Kajiwara, Shigeyasu Tanaka, Yoshiko Itoh, Yutaka Tsutsumi, R. Yoshiyuki Osamura
Journal: Endocrine Pathology (1999)
Prevalence of renal dysfunction in patients with cirrhosis according to ADQI-IAC working party proposal
Authors: Yun Jung Choi, Jeong Han Kim, Ja Kyung Koo, Cho I Lee, Ji Young Lee, Jae Hoon Yang, Soon Young Ko, Won Hyeok Choe, So Young Kwon, Chang Hong Lee
Journal: Clinical and Molecular Hepatology (2014)

Background/Aims A revised classification system for renal dysfunction in patients with cirrhosis was proposed by the Acute Dialysis Quality Initiative and the International Ascites Club Working Group in 2011. The aim of this study was to determine the prevalence of renal dysfunction according to the criteria in this proposal. Methods The medical records of cirrhotic patients who were admitted to Konkuk University Hospital between 2006 and 2010 were reviewed retrospectively. The data obtained at first admission were collected. Acute kidney injury (AKI) and chronic kidney disease (CKD) were defined using the proposed diagnostic criteria of kidney dysfunction in cirrhosis. Results Six hundred and forty-three patients were admitted, of whom 190 (29.5%), 273 (42.5%), and 180 (28.0%) were Child-Pugh class A, B, and C, respectively. Eighty-three patients (12.9%) were diagnosed with AKI, the most common cause for which was dehydration (30 patients). Three patients had hepatorenal syndrome type 1 and 26 patients had prerenal-type AKI caused by volume deficiency after variceal bleeding. In addition, 22 patients (3.4%) were diagnosed with CKD, 1 patient with hepatorenal syndrome type 2, and 3 patients (0.5%) with AKI on CKD. Conclusions Both AKI and CKD are common among hospitalized cirrhotic patients, and often occur simultaneously (16.8%). The most common type of renal dysfunction was AKI (12.9%). Diagnosis of type 2 hepatorenal syndrome remains difficult. A prospective cohort study is warranted to evaluate the clinical course in cirrhotic patients with renal dysfunction. Keywords: Hepatorenal syndrome; Cirrhosis; Acute kidney injury; Chronic kidney disease
Effects of combined ACE inhibitor and angiotensin II antagonist treatment in human chronic nephropathies
Authors: Ruth Campbell, Fabio Sangalli, Elena Perticucci, Claudio Aros, Cecilia Viscarra, Annalisa Perna, Andrea Remuzzi, Federico Bertocchi, Luca Fagiani, Giuseppe Remuzzi, Piero Ruggenenti
Journal: Kidney International (2003)
Lateral Inguinal Hernia Detected on Routine Bone Scan
Authors: JEANNE L PALMER-LAWRENCE, EDWARD F. MAHAN, JOSEPH R. LOGIC
Journal: Clinical Nuclear Medicine (1990)

A case of an inguinal hernia detected during a static bone scan in a 66-year old man is reported. The hernia was visualized on delayed static images of a routine Tc-99m MDP bone scan that was performed for evaluation of chronic, severe back pain. Physical examination demonstrated a partially reducible left inguinal hernia, which correlated with the localized area of increased activity in the left inguinal region seen on delayed images.
Possible Stereotyping in a Personal Essay
Authors: Janice M. Scully
Journal: Annals of Internal Medicine (2010)

Letters20 July 2010Possible Stereotyping in a Personal EssayJanice M. Scully, MDJanice M. Scully, MDFrom Fayetteville, NY 13066.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-2-201007200-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I am writing in response to Smythe's recent essay (1) about the interaction between himself, the chair of a department of surgery, and a black cleaning lady who was grieving the loss of her husband. I have no doubt that his efforts in writing this story were well intended. He probably wanted to increase awareness that we, as doctors, must show compassion both inside and outside the office.I am an internist and a writer; my current focus is writing for children and young adults. I was uncomfortable with what I believe to be stereotyping in Smythe's ...Reference1. Smythe WR. Mattie's visit. Ann Intern Med. 2010;152:470-1. [PMID: 20368655] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Fayetteville, NY 13066.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMattie's Visit W. Roy Smythe Possible Stereotyping in a Personal Essay W. Roy Smythe Metrics 20 July 2010Volume 153, Issue 2Page: 134-135KeywordsChildrenConflicts of interestOverweightSurgeryVisionYoung adults ePublished: 20 July 2010 Issue Published: 20 July 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The cytosolic subunit p67phox contains an NADPH-binding site that participates in catalysis by the leukocyte NADPH oxidase.
Authors: R M Smith, J A Connor, L M Chen, B M Babior
Journal: Journal of Clinical Investigation (1996)

The NADPH-dependent respiratory burst oxidase of human neutrophils catalyzes the reduction of oxygen to superoxide using NADPH as the electron donor and is essential for normal host defenses. To gain insight into the function of the various oxidase subunits that are required for the full expression of catalytic activity, we studied the interactions between the 2',3'-dialdehyde derivative of NADPH (NADPH dialdehyde) and neutrophil cytosol. NADPH dialdehyde treatment of cytosol resulted in the loss of the ability of the cytosol to participate in cell-free oxidase activation; this inactivation was blocked by NADPH but not by NAD, NADP, or GTP. Partial purification of neutrophil cytosol yielded a single peak which could restore the activity lost in cytosol treated with NADPH dialdehyde. This peak contained p67phox but not p47phox or Rac2. Purified recombinant p67phox was similarly able to restore the activity lost in NADPH dialdehyde-treated cytosol and bound [32P]NADPH dialdehyde in a specific fashion. The activity of recombinant p67phox in cell-free oxidase assays was lost on treatment with NADPH dialdehyde. Together, these data suggest p67phox contains the catalytic NADPH-binding site of the leukocyte NADPH oxidase.
High pressure chronic retention.
Authors: N J George, P H O'Reilly, R J Barnard, N J Blacklock
Journal: BMJ (1983)

In a prospective study of high pressure chronic retention, a newly defined disorder of the urinary tract, 21 patients were analysed for their mode of presentation and urodynamic, renographic, and operative findings. High pressure chronic retention is characterised by late onset enuresis, a tense, palpable bladder, hypertension, and progressive renal impairment associated with bilateral hydronephrosis and hydroureter commonly leading to uraemia and death. Obstructive urological symptoms are typically absent in uncomplicated cases. The study confirmed that patients with the disorder are commonly elderly and present, not necessarily to a urologist, with late onset enuresis or symptoms of cardiac decompensation. After transurethral resection the patients, if correctly managed, may be expected to make a satisfactory recovery.
A late complication of a diagnostic mediastinoscopy.
Authors: H F Hoitsma, E T Tjho, M A Cuesta
Journal: Thorax (1978)

A 69-year-old man with a moderately well differentiated squamous-cell carcinoma of the lung, underwent a mediastinoscopy. All histological examinations of the mediastinal nodes were negative. The patient was treated with a curative left pneumonectomy. Three months after this negative mediastinoscopy the patient developed a metastasis in the mediastinoscopy scar. A report of this case and a review of the literature are presented.
Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats.
Authors: Shakil A Saghir, Irvin R Schultz
Journal: Environmental Health Perspectives (2002)

We studied the pharmacokinetics of dichloroacetate (DCA) in naive rats and rats depleted of glutathione S-transferase-zeta (GST-zeta), at doses approaching human daily exposure levels. We also compared in vitro metabolism of DCA by rat and human liver cytosol. Jugular vein-cannulated male Fischer-344 rats received graded doses of DCA ranging from 0.05 to 20 mg/kg (intravenously or by gavage), and we collected time-course blood samples from the cannulas. GST-zeta activity was depleted by exposing rats to 0.2 g/L DCA in drinking water for 7 days before initiation of pharmacokinetic studies. Elimination of DCA by naive rats was so rapid that only 1-20 mg/kg intravenous and 5 and 20 mg/kg gavage doses provided plasma concentrations above the method detection limit of 6 ng/mL. GST-zeta depletion slowed DCA elimination from plasma, allowing kinetic analysis of doses as low as 0.05 mg/kg. DCA elimination was strongly dose dependent in the naive rats, with total body clearance declining with increasing dose. In the GST-zeta-depleted rats, the pharmacokinetics became linear at doses less than or equal to 1 mg/kg. Virtually all of the dose was eliminated through metabolic clearance; the rate of urinary elimination was < 1 mL/hr/kg. At higher oral doses (less than or equal to 5 mg/kg in GST-zeta-depleted and 20 mg/kg in naive rats), secondary peaks in the plasma concentration appeared long after the completion of the initial absorption phase. Oral bioavailability of DCA was 0-13% in naive and 14-75% in GST-zeta- depleted rats. Oral bioavailability of DCA in humans through consumption of drinking water was predicted to be very low and < 1%. The use of the GST-zeta-depleted rat as a model for assessing the kinetics of DCA in humans is supported by the similarity in pharmacokinetic parameter estimates and rate of in vitro metabolism of DCA by human and GST-zeta-depleted rat liver cytosol.
Non-publication of tobacco funded research should extend to replacement nicotine studies funded by the drug industry
Authors: J. R. Polito
Journal: BMJ (2013)

<h3>Background</h3> Chronic cough is a common childhood symptom, reported in 22% of preschool children. Many are misdiagnosed as asthmatic. Induced sputum (IS) using hypertonic saline (HTS) has been used as a diagnostic tool in patients with cough; its bronchoconstriction effects being used as a test for the bronchial hyper-reactivity (BHR) in asthma (ISSAC study). Conversely it is used as a bronchodilator in the treatment of bronchiolitis and pre-school wheeze. Sputum eosinophilia indicates airway inflammation in keeping with a diagnosis of asthma. This study aimed to determine if IS is a feasible diagnostic tool in children with problem cough query asthma. In addition we wished to determine the relationship between BHR to HTS and the eosinophil count in sputum. <h3>Methods</h3> A retrospective review of children with problem cough who underwent sputum induction with nebulised 3% HTS. Sputum samples were obtained for microbiology, virology and differential cell count. Spirometry was performed before and after administration of 3% HTS. Change in FEV<sub>1</sub> (Δ FEV<sub>1</sub> = FEV<sub>1</sub> post HTS minus FEV<sub>1</sub> pre HTS) was used as a measure of BHR. Correlation between Δ FEV<sub>1</sub> and sputum eosinophilia was calculated using Spearmen rank coefficient. <h3>Results</h3> 146 patients referred for IS between 2001 and January 2013 were included. Mean age = 8 years (range = 2 to 13), mean cough duration = 4.25 years (range 0.17 to 11.5). Sputum induction was successful in 131 patients (89%). 12 children (8%) became symptomatic; 4% required test termination. 44 children increased FEV<sub>1</sub> with 12 having &gt;9% FEV<sub>1</sub> increase. 63 children reduced FEV<sub>1 </sub>with 21 having &gt; 9% reduction. Viral or bacterial pathogens were identified in 29% of samples obtained. Sputum eosinophilia (eosinophil count &gt; 3%) was present in 66% of samples obtained. There was no correlation between FEV<sub>1</sub> and sputum eosinophilia (R = 0.04). <h3>Conclusions</h3> IS is a feasible and safe tool in children with problem chronic cough, aiding diagnosis with spirometry and sputum analysis. However BHR induced with HTS does not correlate with sputum eosinophilia. Several children increased FEV<sub>1</sub> with HTS administration, suggesting it may have a therapeutic role in the treatment of some children with chronic cough.
The Pathophysiology of Ocular Allergy: Current Thinking
Authors: C Stephen Foster
Journal: Allergy (1995)

Summary Seasonal allergic conjunctivitis is the only ocular disease to involve solely Type‐1 hypersensitivity, the other main forms of ocular allergy ‐ perennial allergic conjunctivitis, vernal and atopic keratoconjunctivitis and giant papillary conjunctivitis ‐ each having a more complex immunological basis and a chronic inflammatory component. Involvement of secondary inflammatory cells, particularly eosinophils, in addition to the mast cells resident in the conjunctival substantia propria, can lead to more serious corneal damage with vision‐threatening potential. Thoughtful management of allergic conjunctivitis is needed in order to control the ocular inflammation without incurring steroid‐induced side‐effects, and patient education is also an important factor in maintaining optimal allergen avoidance, especially in the more severe and chronic cases. Laboratory models can be helpful in assessing the potential of new drugs, and SWR mice (topically sensitised and challenged with short ragweed) show clinical signs of allergic conjunctivitis, together with mast cell and eosinophil involvement, remarkably similar to the human pathophysiology. The antiinflammatory activity of both steroids and nedocromil sodium observed in this animal model supports therapeutic evidence of the usefulness of second‐generation mast cell stabilising drugs in the treatment of ocular allergy.
Cold Defect on Indium Leukocyte Scanning of a Hepatic Abscess
Authors: GLENN W. BURRIS, BRIAN M. GORDON
Journal: Clinical Nuclear Medicine (1998)

Abdominal and, specifically, hepatic abscesses have always been difficult to diagnose clinically. The In-111 leukocyte scan has proven to be a valuable modality assisting in the diagnosis of an abscess. The authors present the case of a 64-year-old man who presented with vague clinical symptoms and inconclusive laboratory data for a hepatic abscess. Both the ultrasound and CT scan were nondiagnostic; however, a distinct cold defect within the liver on an In-111 leukocyte scan resulted in a liver biopsy, confirming the presence of an abscess. The potential causes of cold defects on In-111 WBC scanning and the limitations of this modality are discussed.
Former heads of Mid Staffs trust to be investigated for criminal charges
Authors: C. Dyer
Journal: BMJ (2013)

Stafford Borough Council is to ask the police to investigate whether the former chair and the chief executive of Mid Staffordshire NHS Foundation Trust committed a criminal offence in failing to disclose high mortality rates at Stafford Hospital to the council’s scrutiny committee.

The council agreed a motion to refer former chief executive Martin Yeates and former trust chairwoman Toni Brisby for investigation …
Facultative skin pigmentation in caucasians: an objective biological indicator of lifetime exposure to ultraviolet radiation?
Authors: None Lock‐Andersen, None Knudstorp, None Wulf
Journal: British Journal of Dermatology (1998)

To investigate age and gender trends in facultative and constitutive skin pigmentation we measured skin pigmentation non-invasively and objectively by skin reflectance spectroscopy in 653 caucasians (336 females and 317 males; mean age 38 years, range 0–85) who were not using artificial tanning devices. In all subjects, measurements were performed in the late winter and pre-spring period at five sites exposed to ultraviolet (UV) radiation: the forehead, the upper chest, the upper back and the lateral and medial aspects of the upper arm, and in UV-unexposed buttock skin. Constitutive pigmentation at the buttocks was highest in the first years of life and then decreased substantially during the first two decades of life (P < 0.01). After the age of 25 years, buttock pigmentation remained at a constant level (P = 0.20). There was no gender difference in constitutive pigmentation. Facultative skin pigmentation increased with age for all the measured sites with the highest levels found at the lateral aspect of the upper arm. Based on observations in this study we propose the idea of a ‘sun exposure index’ (SEI) for individuals, based on objective measurements of skin pigmentation. The SEI is calculated as the increase in facultative pigmentation above the constitutive level and is expressed as a percentage of the constitutive level. The SEI appeared to be related to cumulative lifetime UV exposure and may be used in epidemiological research as an objective estimate of UV exposure at different body sites in caucasians.
An Evaluation of Transfer Factor as Immunotherapy for Patients with Lepromatous Leprosy
Authors: Ward E. Bullock, James P. Fields, Michael W. Brandriss
Journal: New England Journal of Medicine (1972)

Transfer factor or whole lymphocytes from donors with delayed hypersensitivity to antigens of Mycobacterium leprae were employed to reconstitute delayed hypersensitivity in nine patients with anergic leprosy. Five received a mean of 4.1 X 108 lymphocytes, and four received transfer factor from equivalent cell numbers. One to six days after transfer, six of nine patients experienced erythematous indurative changes within leprous skin infiltrates that regressed by the 12th day. Simultaneously, erythema nodosum occurred in four patients, and fever and arthralgia in three. Six of seven converted from anergy to a delayed hypersensitivity response to M. leprae antigens. The seventh became skin-test positive at the "local" site of injection only, and the test reverted to negative seven days later. Two of three patients showed an increase in perivascular lymphocytic infiltration in the post-transfer skin-test biopsy site. Delayed hypersensitivity reactions to M. leprae antigens can be produced, with lymphocytes or their extracts, in patients with anergic leprosy.
Spontaneously Remitting Spinal Epidural Hematoma in a Patient on Anticoagulants
Authors: Sami I. Harik, Marcus E. Raichle, Donald J. Reis
Journal: New England Journal of Medicine (1971)

ACUTE spinal epidural hemorrhage (SEH) is a potentially curable cause of spinal-cord and root compression if recognized and treated promptly. The treatment of choice is immediate surgical decompression. Of more than 100 cases existent in the literature, spontaneous recovery occurred in only one.1 That patient had hemophilia, and his condition was considered inoperable. In all other cases failure to operate resulted in permanent paraplegia and often death from the attendant complications.This report documents the second case of complete spontaneous recovery from an acute SEH. This patient, who was on anticoagulants, was recovering from an acute myocardial infarction.In addition, . . .
Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL
Authors: Anna Vardi, Antonis Dagklis, Lydia Scarfò, Diane Jelinek, Darren Newton, Fiona Bennett, Julia Almeida, Arancha Rodriguez-Caballero, Sallie Allgood, Mark Lanasa, Agostino Cortelezzi, Ester Orlandi, Silvio Veronese, Marco Montillo, Andy Rawstron, Tait Shanafelt, Alberto Orfao, Kostas Stamatopoulos, Paolo Ghia
Journal: Blood (2013)
Cardiovascular Imaging and Outcomes — PROMISEs to Keep
Authors: Christopher M. Kramer
Journal: New England Journal of Medicine (2015)

Noninvasive cardiovascular imaging is used on a daily basis to make crucial decisions regarding patient care. However, its rising use paralleled the doubling in Medicare spending on imaging services under the Part B physician fee schedule from 2000 to 2006, of which approximately one third was for cardiovascular imaging.1 As a result, the American College of Cardiology Foundation and other societies developed appropriate-use criteria2 for cardiovascular imaging that apply expert opinion to various imaging methods in common clinical scenarios to recognize those that are appropriate, may be appropriate, or are rarely appropriate in a given scenario. Cardiovascular imaging procedures and . . .
Progress in the Determination of Histocompatibility
Authors: J. Wayne Streilein
Journal: JAMA (1966)

Experimental and clinical data currently available suggest that of the various possible ways in which the outcome of organ homotransplantation might be improved upon, the one which holds most immediate promise involves devising a selection procedure capable of excluding gross histoincompatibilities. The various approaches to the problem of tissue typing or matching that are presently being investigated are reviewed from the viewpoint of their underlying principles and their potentialities. These methods include direct grafting tests, serologic procedures aimed at matching or identifying pertinent isoantigenic specificities associated with formed elements of the blood, especially leukocytes, and various extracorporeal biologic assays of the capacity of an intended host's immunologically competent cells to react against the transplantation isoantigens of a possible donor. The latter category of tests includes the normallymphocyte transfer test and the irradiated-hamster test.