Anti-Neutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis
Authors: Stephen L. Scheeler
Journal: Annals of Internal Medicine (1991)

Letters1 March 1991Anti-Neutrophil Cytoplasmic Autoantibody-Associated GlomerulonephritisStephen L. Scheeler, MDStephen L. Scheeler, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-5-430 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In their study of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis and systemic vasculitis, Falk and associates (1) conclude that "therapy with either intravenous cyclophosphamide or oral cyclophosphamide is effective in patients with renal-limited disease as well as in those with glomerulonephritis and alveolar hemorrhage." In their experience, intravenous cyclophosphamide had proved to be a reliable and efficacious therapy.These findings are at odds with those of Hoffman and co-workers (2), who did a study of pulse intravenous cyclophosphamide as therapy for Wegener granulomatosis. These investigators noted an initial high percentage of responders. However, the long-term failure rate was...References1. FalkHoganCareyJennette RSTJ. Clinical course of anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and systemic vasculitis. Ann Intern Med. 1990;113:656-63. LinkGoogle Scholar2. HoffmanLeavittFleisherMinorFauci GRTJA. Treatment of Wegener's granulomatosis with intermittent high-dose intravenous cyclophosphamide. Am J Med. 1990;89:403-10. CrossrefMedlineGoogle Scholar3. FauciHaynesKatzWolff ABPS. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98:76-85. LinkGoogle Scholar4. Cupps T. Cyclophosphamide: to pulse or not to pulse? Am J Med. 1990;89:399-402. CrossrefMedlineGoogle Scholar5. NolleSpecksLudemannRohrbachDe RemeeGross BUJMRW. Anticytoplasmic autoantibodies: their immunodiagnostic value in Wegener granulomatosis. Ann Intern Med. 1989;111:28-40. LinkGoogle Scholar1. FalkHoganCareyJennette RSTJ. Clinical course of anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and systemic vasculitis. Ann Intern Med. 1990;113:656-63. LinkGoogle Scholar2. HoffmanLeavittFleisherMinorFauci GRTJA. Treatment of Wegener's granulomatosis with intermittent high-dose intravenous cyclophosphamide. Am J Med. 1990;89:403-10. CrossrefMedlineGoogle Scholar3. JennetteWilkmanFalk JAR. Anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis. Am J Pathol. 1989;135:921-30. MedlineGoogle Scholar4. Falk R. ANCA-associated renal disease. Kidney Int. 1990;38:998-1010. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Center for Rheumatic Diseases, Ltd. 8218 Wisconsin Avenue Bethesda, MD 20814 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGoodpasture's syndrome 1 March 1991Volume 114, Issue 5Page: 430-431KeywordsAutoantibodiesCyclophosphamideGlomerulonephritisHeart rateHemorrhageRenal diseasesSystemic diseasesVasculitisWegener granulomatosis Issue Published: 1 March 1991 PDF DownloadLoading ...