tbuckley/cabot-search huggingface dataset:
Lymph Circulation in Congestive Heart Failure
Authors: MARLYS HEARST WITTE, ALLAN E. DUMONT, ROY H. CLAUSS, BERTHA RADER, NORMAN LEVINE, ERNEST S. BREED
Journal: Circulation (1969)

The lymphatic circulation was evaluated after cannulation of the cervical thoracic duct in 12 patients with severe intractable congestive heart failure. After venting the distended duct, lymph flowed rapidly under increased pressure, and signs and symptoms of circulatory congestion were dramatically relieved. Dyspnea, orthopnea, anorexia, abdominal discomfort, distended neck veins, hepatomegaly, peripheral and scrotal edema, and ascites diminished or disappeared. Central venous pressure fell and armto-tongue circulation time decreased. In some patients arterial pressure, amplitude of peripheral pulses, central venous Po 2 , and urinary output rose further suggesting enhanced cardiac output. Considered together with previous observations in experimental animals, the findings indicate that elevated systemic venous pressure greatly increases formation of thoracic duct lymph but at the same time impedes the return of lymph into the great veins. While therapeutic drainage of lymph from the thoracic duct in patients with cardiac failure is limited, the capacity of the lymphatic system to transport excess capillary filtrate back to the blood stream constitutes a major control mechanism regulating the manifestations of this disorder.
Exercise and Cancer: No Pain, Some Gain?
Authors: Daniel Rayson, Leonard Reyno
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.12.066 Journal of Clinical Oncology - published online before print November 1, 2016 PMID: 12721237 Exercise and Cancer: No Pain, Some Gain? Daniel RaysonxDaniel RaysonSearch for articles by this author , Leonard ReynoxLeonard ReynoSearch for articles by this author Show More QEII Cancer Care Program Halifax, Nova Scotia, Canada https://doi.org/10.1200/JCO.2003.12.066 Full Text PDF Figures and Tables "Exercise and Cancer: No Pain, Some Gain?." Journal of Clinical Oncology, 21(9), pp. 1651–1652© 2003 by American Society of Clinical Oncology
Implementing guidelines on sudden infant death
Authors: Anne Livesey, Edmund Hick
Journal: BMJ (2004)

EDITOR—Fleming et al described a multi-agency approach to investigating unexpected infant deaths.1 Such a multiagency protocol—adopted by the police, health, social services, and coroners—has existed in Sussex since 1999. This precedent was acknowledged in the Avon protocol described by Fleming et al.1

With support from the Foundation for the Study …
Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas
Authors: Santiago Montes-Moreno, Giovanna Roncador, Lorena Maestre, Nerea Martínez, Lydia Sanchez-Verde, Francisca I. Camacho, Jimena Cannata, Jorge L. Martinez-Torrecuadrada, Yulei Shen, Wing C. Chan, Miguel A. Piris
Journal: Blood (2007)
The Weight of the Heart and Its Chambers in Hypertensive Cardiovascular Disease with and without Failure
Authors: RUSSELL S. JONES
Journal: Circulation (1953)

The myocardial weights of the different cardiac chambers were determined in 130 cases of hypertensive cardiovascular disease, both with and without failure. The left ventricle hypertrophies before and continues to hypertrophy after the advent of congestive failure. The right ventricle and both auricles hypertrophy only after failure develops. In correlating the ventricular work with its muscle mass, the left ventricle apparently performs twice as much work per gram as the right ventricle. Several possible explanations for this apparent greater efficiency of the left ventricle are presented. The changes in chamber weights are discussed in relation to concepts of congestive failure.
Patterns of bleeding in adolescents with severe haemophilia A.
Authors: A Aronstam, S G Rainsford, M J Painter
Journal: BMJ (1979)

Eighty-two boys with severe haemophilia A who spent some time at Lord Mayor Treloar College during 1973-7 were studied. All episodes of bleeding that occurred during term time were recorded, along with the number of transfusions. The bleeding frequency among these boys, most of them aged 10-17 years, increased steadily from 8,31 episodes/100 days in 1973 to 12,63 episodes/100 days in 1977. At the same time there was a steady fall in bleeding frequency with age. Altogether 24% of bleeding episodes were into the elbow joint, 22% into the knee, and 15% into the ankle. As the boys grew older the proportion of bleeding episodes in the legs declined and that in the arms increased. The overall results reflect the fact that special schools now see only the severest cases of haemophilia. The pattern of bleeding during adolescence suggests that concepts of management of arm bleeding need modifying.
ESC Textbook of Cardiovascular Medicine
Authors: Gottlieb C. Friesinger, Desmond G. Julian, Elliot Rapaport
Journal: Circulation (2006)

To ensure the book was read in its entirety, the text was divided into thirds and apportioned equally to each reviewer; all 3 reviewers were assigned 4 chapters in common to read as well.This summary review by 3 individuals, each of whom is internationally recognized for expertise in the broad field of general cardiology, is offered in the spirit of helping the ESC achieve its stated objective of providing a textbook that is successful in covering the knowledge that should be required of all general cardiologists.
Our Precarious Habitat
Authors: Matthew J. Kotchen
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OVULATION AND MENSTRUATION
Authors: Wilfred Shaw
Journal: JAMA (1934)

To the Editor:—  I should like to be given the opportunity of replying to Dr. Novak's letter inThe Journaldated April 21.  I agree with Hartman that the disintegration changes in the endometrium during the anovular cyclic hemorrhage of the macaque and during  in the human female are almost identical. Probably in metropathia haemorrhagica the same process is also at work. So far as the macaque is concerned the disintegration changes seem to be the same whether the cycle is ovular or anovular and one is justified in assuming that the final cause of the bleeding is of a similar nature in these two cases and during  in the human female. Robert Meyer and Schroder have suggested that the word menstruation should be restricted to the ovular cyclic bleeding and that the term pseudomenstruation should be used for anovular cyclic bleeding. The distinction may appear trivial, especially
SILVER IN THE URINE
Authors: T. Nelson Carey
Journal: JAMA (1942)

<h3>To the Editor:—</h3> We have read the communication by Dr. Joseph C. Aub and Dr. Lawrence T. Fairhall (The Journal, Jan. 24, 1942, p. 319) in which the view is expressed that silver is not excreted in the urine. Since the comparatively non-strategic nature of silver has encouraged its industrial use during the emergency to replace some of its lowly but more essential metallic relatives, the subject of silver pharmacology may assume greater importance. We wish to call attention to our report of a case of obscure argyria with argyremia (The Journal, Nov. 17, 1934, p. 1521) in which it was demonstrated spectrographically that under certain conditions, at least, significant amounts of silver may be eliminated from the body by excretion in the urine even three months after the cessation of silver ingestion. However, in an old case of well pigmented argyria in which there had been no abnormal silver
TREATMENT OF BURNS
Authors: Gustav A. Pagenstecher
Journal: JAMA (1925)

The treatment of extensive second and third degree burns has taken on a new turn since the work of Cannon<sup>2</sup>and Willis.<sup>3</sup>The new procedures are destined to reduce mortality, reduce damage to internal viscera due to absorption of protein toxin of slough, alleviate pain, shorten convalescence, reduce the necessity of doing skin grafts, and prevent contractures. The primary procedure is to remove the entire burned area with a sharp knife, the débridement extending down to healthy tissue. All bleeding points are stopped by ligature, and the oozing is stopped by applying a saturated alcoholic solution of picric acid to the surface. In addition to the hemostatic effect, the picric acid combats any skin infection that may be present. The entire procedure is done under gas anesthesia, this causing less shock, and no preliminary morphin is given. The latter is avoided because it has a deleterious and depressing
Blood Transfusion and Breast Milk Transmission of Cytomegalovirus in Very Low-Birth-Weight Infants
Authors: Cassandra D. Josephson, Angela M. Caliendo, Kirk A. Easley, Andrea Knezevic, Neeta Shenvi, Michael T. Hinkes, Ravi M. Patel, Christopher D. Hillyer, John D. Roback
Journal: JAMA Pediatrics (2014)

Postnatal cytomegalovirus (CMV) infection can cause serious morbidity and mortality in very low-birth-weight (VLBW) infants. The primary sources of postnatal CMV infection in this population are breast milk and blood transfusion. The current risks attributable to these vectors, as well as the efficacy of approaches to prevent CMV transmission, are poorly characterized. To estimate the risk of postnatal CMV transmission from 2 sources: (1) transfusion of CMV-seronegative and leukoreduced blood and (2) maternal breast milk. A prospective, multicenter birth-cohort study was conducted from January 2010 to June 2013 at 3 neonatal intensive care units (2 academically affiliated and 1 private) in Atlanta, Georgia. Cytomegalovirus serologic testing of enrolled mothers was performed to determine their status. Cytomegalovirus nucleic acid testing (NAT) of transfused blood components and breast milk was performed to identify sources of CMV transmission. A total of 539 VLBW infants (birth weight, ≤ 1500 g) who had not received a blood transfusion were enrolled, with their mothers (n = 462), within 5 days of birth. The infants underwent serum and urine CMV NAT at birth to evaluate congenital infection and surveillance CMV NAT at 5 additional intervals between birth and 90 days, discharge, or death. Blood transfusion and breast milk feeding. Cumulative incidence of postnatal CMV infection, detected by serum or urine NAT. The seroprevalence of CMV among the 462 enrolled mothers was 76.2% (n = 352). Among the 539 VLBW infants, the cumulative incidence of postnatal CMV infection at 12 weeks was 6.9% (95% CI, 4.2%-9.2%); 5 of 29 infants (17.2%) with postnatal CMV infection developed symptomatic disease or died. A total of 2061 transfusions were administered among 57.5% (n = 310) of the infants; none of the CMV infections was linked to transfusion, resulting in a CMV infection incidence of 0.0% (95% CI, 0.0%-0.3%) per unit of CMV-seronegative and leukoreduced blood. Twenty-seven of 28 postnatal infections occurred among infants fed CMV-positive breast milk (12-week incidence, 15.3%; 95% CI, 9.3%-20.2%). Transfusion of CMV-seronegative and leukoreduced blood products effectively prevents transmission of CMV to VLBW infants. Among infants whose care is managed with this transfusion approach, maternal breast milk is the primary source of postnatal CMV infection. clinicaltrials.gov Identifier: NCT00907686.
TRAUMATIC CALCINOSIS OF THE SKIN.
Authors: I. B. SNEDDON, R. McL. ARCHIBALD
Journal: British Journal of Dermatology (1958)

Journal Article TRAUMATIC CALCINOSIS OF THE SKIN. Get access I. B. SNEDDON, M.B. Ch.B., F.R.C.P., and, I. B. SNEDDON, M.B. Ch.B., F.R.C.P., and Consultant Dermatologist, Rupert Hallam Department of Dermatology, Sheffield Search for other works by this author on: Oxford Academic Google Scholar R. McL. ARCHIBALD, M.B., Ch.B., D.I.H. R. McL. ARCHIBALD, M.B., Ch.B., D.I.H. Medical Officer, North Eastern Division, National Coal Board Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 70, Issue 6, 1 June 1958, Pages 211–214, https://doi.org/10.1111/j.1365-2133.1958.tb13323.x Published: 01 June 1958
Human Papillomavirus Infection and Incidence of Squamous Cell and Basal Cell Carcinomas of the Skin
Authors: Margaret R. Karagas, Heather H. Nelson, Peter Sehr, Tim Waterboer, Therese A. Stukel, Angeline Andrew, Adele C. Green, Jan Nico Bouwes Bavinck, Ann Perry, Steven Spencer, Judy R. Rees, Leila A. Mott, Michael Pawlita
Journal: JNCI Journal of the National Cancer Institute (2006)

Background: Although infection with human papillomaviruses (HPVs) is a major risk factor for several epithelial cancers, an etiologic relationship between HPV and keratinocyte cancers, such as squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs), remains unclear. Methods: In a population-based case–control study of 252 SCC case patients, 525 BCC case patients, and 461 control subjects, we used multiplex serology to detect antibodies in plasma samples against 16 HPV types from phylogenetic genera alpha, beta, and mu. Multiplex serology is a new method that is based on fluorescent bead technology and allows simultaneous detection of antibodies against up to 100 different in situ affinity-purified recombinant HPV proteins. Data on sun sensitivity, outdoor exposure, and other risk factors for keratinocyte cancers were collected through personal interviews. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated via unconditional logistic regression models. Results: Overall, we detected HPV antibodies more frequently in SCC patients than in control subjects (OR = 1.6, 95% CI = 1.2 to 2.3), but we found no difference in HPV seropositivity between BCC case patients and control subjects (OR = 0.8, 95% CI = 0.6 to 1.1). Among HPV types, seropositivity to HPV types in genus beta (OR = 1.5, 95% CI = 1.0 to 2.1), particularly HPV 5 (OR = 1.8, 95% CI = 1.0 to 3.1), was associated with SCC risk. Individuals with tumors on chronically sun exposed sites were more likely to be seropositive for beta HPV types than individuals with SCC at other anatomic sites. The highest SCC risk was associated with positivity for multiple HPV types and, among individuals seropositive for HPV beta, a tendency to sunburn; however, the associations had limited statistical precision. Conclusions: Our findings support a role for HPV types from the genus beta in the pathogenesis of SCC.
Malignant Transformation of Hyperplasiogenic Polyps of the Stomach: – Case Report –
Authors: W. Remmele, E. Kolb
Journal: Endoscopy (1978)

Case report of a 71 years old female with multiple hyperplasiogenic gastric polyps with malignant transformation of two polyps. So far, the hyperplasiogenic polyp was considered to be only an “indicator lesion” because the incidence of gastric cancer (apart from the polyps themselves) was found to be increased in these patients. This opinion has to be revised in view of the present case. The consequences for diagnosis, treatment and nosologic classification of hyperplasiogenic gastric polyps are discussed.
Chronic Bifascicular Block: Evaluation of Familial Factors
Authors: BRUCE R. GREENSPAHN
Journal: Annals of Internal Medicine (1976)

We studied whether familial factors are significant in chronic bifascicular block. One hundred thirty-four first- and second-degree relatives of 44 outpatients with chronic bifascicular block were examined. These relatives were studied to ascertain the presence or absence of cardiac disease and conduction defects. A race-, age-, and sex-matched control group (age range, 18 to 65) was randomly chosen from a population of employed volunteers for comparison purposes. The study group had a significantly greater frequency of conduction defects than the control group (24/95 versus 10/95, P < 0.02). Study group members less than 18 years of age (32 patients) had a similar frequency of conduction defects when compared with patients described in the literature. In study group members older than 65 years, 5 out of 7 had conduction defects, a high frequency. In conclusion, the findings suggest an age-related familial tendency to conduction disease among relatives of patients with chronic bifascicular block.
Psychological Weil-Being: Meaning, Measurement, and Implications for Psychotherapy Research
Authors: Carol D. Ryff, Burton Singer
Journal: Psychotherapy and Psychosomatics (1996)

A model of positive psychological functioning that emerges from diverse domains of theory and philosophy is presented. Six key dimensions of wellness are defined, and empirical research summarizing their empirical translation and sociodemographic correlates is presented. Variations in well-being are explored via studies of discrete life events and enduring human experiences. Life histories of the psychologically vulnerable and resilient, defined via the cross-classification of depression and well-being, are summarized. Implications of the focus on positive functioning for research on psychotherapy, quality of life, and mind/body linkages are reviewed.
A MEMORABLE PATIENT
Authors: H Klonin, C Vickery
Journal: BMJ (1996)

While working in tuberculosis clinics in a remote area of Nepal we saw two patients who had difficulty sleeping after pleural aspiration and a striking case of sleep disturbance in the spouse of a third patient.

We first encountered the problem with a 52 year old man who was found to be sputum positive for acid and alcohol fast bacilli. Despite his weight loss and cough, dyspnoea was his presenting symptom. On examination he had a pleural effusion. After a month of short course chemotherapy his sputum was negative for acid and alcohol fast bacilli, but his dyspnoea had worsened and his pleural effusion was larger.

A litre of …
The poor man at his gate
Authors: I. Heath
Journal: BMJ (1994)

Amid the seasonal excesses it is easy to forget that at the heart of the Christmas story is a homeless family. To restore some balance to what is now a celebration of consumption it is useful to speculate what would have become of Mary and Joseph if—finding themselves in central London—they had presented themselves to Westminster City Council's Homeless Persons Unit. The bleak midwinter is exactly the right time to reflect on homelessness, and as members of a profession doctors have not only the right but the responsibility to speak out on matters of social justice.1

Two recent reports do just that. Together they explore evidence pointing consistently to the conclusion that homelessness is destructive of health, and they make an unanswerable case for social investment in housing as a way of protecting the health of our most socioeconomically deprived …
Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis
Authors: François Delhommeau, Sabrina Dupont, Carole Tonetti, Aline Massé, Isabelle Godin, Jean-Pierre Le Couedic, Najet Debili, Patrick Saulnier, Nicole Casadevall, William Vainchenker, Stéphane Giraudier
Journal: Blood (2006)
Effect of Dibenzyline on Skin Temperature, Peripheral Blood Flow, and Vasomotor Responses in Normal Patients and Patients with Increased Vasoconstrictor Tone
Authors: MARVIN MOSER, DALE WATKINS, NEAL MORRIS, ANDREW G. PRANDONI, THOMAS W. MATTINGLY
Journal: Circulation (1953)

Dibenzyline is an orally effective, moderately potent, long acting, adrenergic blocking agent. The drug is capable of at least partially preventing the vasoconstrictor responses to cold and to injected Neosynephrine. Blood flow and temperature responses to this agent do not always parallel results obtained following surgical sympathectomy, but the degree of effect appears to be sufficient to produce a clinical response. Side effects and the development of "tolerance" may limit the use of Dibenzyline in clinical medicine.
Delayed hypersensitivity due to epidural block with ropivacaine
Authors: Masanori Ban, Masahito Hattori
Journal: BMJ (2005)

Ropivacaine, introduced in 1995, is an amide-type local anaesthetic.It consists of pure optical S-(-)-isomers and has a low cardiotoxicity.We report delayed hypersensitivity reactions to ropivacaine.A 74 year old man with postherpetic neuralgia started taking amitriptyline, alprazolam, and loxoprofen and underwent an epidural block with 0.2% ropivacaine hydrochloride without preservatives (48 ml or 96 ml daily).He had no history of allergy to any local anaesthetics.Two weeks later, purpuric rash appeared on his legs, and two days afterwards he developed a widespread blotchy erythema on his trunk and arms (figure).Laboratory examination showed normal white cell and platelet counts and slight eosinophilia (640/mm 3 ).The epidural block and the drugs were stopped, and the eruptions completely resolved within seven days.We did an intradermal test with 0.2% ropivacaine from a plastic ampoule without a rubber stopper.Erythema (maximum size was 23 mm×13 mm) appeared 8-72 hours after the injection.We did the test again and took a specimen for biopsy.Histology showed perivascular infiltrates of lymphocytes and eosinophils in the dermis.Patch testing with amitriptyline, alprazolam, and loxoprofen induced no eruptions, nor did restarting the drugs.Eleven cases of delayed-type hypersensitivity reactions have been reported, caused by local injections of amides such as lignocaine, mepivacaine, and prilocaine. [1]2][3][4][5] The symptoms were erythema, papules, vesicles, and swelling, but they did not include purpuric rash.No cases related to an epidural block or ropivacaine have been reported.Ropivacaine may cause allergic reactions characterised by signs such as urticaria, angioneurotic oedema, tachycardia, and vomiting, but delayed hypersensitivity reactions are not referred to in the Physicians' Desk Reference.The manufacturer also has had no similar reports.
STERILE MENINGITIS FOLLOWING LUMBAR PUNCTURE
Authors: LEWIS M. HURXTHAL
Journal: JAMA (1933)

Reactions following lumbar puncture should be of interest to the surgeon as well as to the internist in view of the widespread use of spinal anesthesia during the past few years. Usually the only reaction following lumbar puncture is headache. When some substance is injected into the spinal canal, local irritation might be expected, and probably occurs frequently, although it rarely produces symptoms.  I have seen one case in which, following spinal anesthesia, mild meningeal symptoms developed. The spinal fluid showed not more than 100 cells, which were mostly polymorphonuclears. There were no organisms seen in the centrifugated fluid, and attempts to culture bacteria failed. Physical signs disappeared within twenty-four hours.  Streptococcus meningitis followed spinal anesthesia in a patient whom I saw in consultation outside the clinic. The cell count varied between 1,000 and 2,000 per cubic millimeter on repeated examinations, and streptococcus was cultivated on three occasions. After repeated