Could Increasing the Duration of Triple Therapy Be a Clinically Useful Strategy?
Authors: Xavier Calvet, Albert Villoria, Mercedes Vergara
Journal: Annals of Internal Medicine (2008)

Letters15 April 2008Could Increasing the Duration of Triple Therapy Be a Clinically Useful Strategy?Xavier Calvet, MD, PhD, Albert Villoria, MD, and Mercedes Vergara, MD, PhDXavier Calvet, MD, PhDFrom Hospital de Sabadell, CIBERehd Instituto de Salud Carlos III, Sabadell 08208, Spain.Search for more papers by this author, Albert Villoria, MDFrom Hospital de Sabadell, CIBERehd Instituto de Salud Carlos III, Sabadell 08208, Spain.Search for more papers by this author, and Mercedes Vergara, MD, PhDFrom Hospital de Sabadell, CIBERehd Instituto de Salud Carlos III, Sabadell 08208, Spain.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-8-200804150-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We would like to congratulate Fuccio and colleagues (1) on their well-performed meta-analysis comparing different durations of triple therapy for Helicobacter pylori infection. However, we disagree with their conclusion that prolonging treatment is unlikely to be a clinically useful strategy. In our opinion, this statement is not supported by their results. The authors confirm previous findings (2, 3) that extending duration of treatment from 7 days to 10 or 14 days improves eradication rates, although the improvements in eradication rates (4% for 10 days and 5% for 14 days) were slightly lower than those previously reported (3% ...References1. Fuccio L, Minardi ME, Zagari RM, Grilli D, Magrini N, Bazzoli F. Meta-analysis: duration of first-line proton-pump inhibitor based triple therapy for Helicobacter pylori eradication. Ann Intern Med. 2007;147:553-62. [PMID: 17938394] LinkGoogle Scholar2. Calvet X, Ducons J, Bujanda L, Bory F, Montserrat A, Gisbert JP. Hp Study Group of the Asociación Española de Gastroenterología. Seven versus ten days of rabeprazole triple therapy for Helicobacter pylori eradication: a multicenter randomized trial. Am J Gastroenterol. 2005;100:1696-701. [PMID: 16086704] CrossrefMedlineGoogle Scholar3. Ford A, Moayyedi P. How can the current strategies for Helicobacter pylori eradication therapy be improved? Can J Gastroenterol. 2003;17 Suppl B 36B-40B. [PMID: 12845349] CrossrefMedlineGoogle Scholar4. Zagari RM, Bianchi-Porro G, Fiocca R, Gasbarrini G, Roda E, Bazzoli F. Comparison of 1 and 2 weeks of omeprazole, amoxicillin and clarithromycin treatment for Helicobacter pylori eradication: the HYPER Study. Gut. 2007;56:475-9. [PMID: 17028126] CrossrefMedlineGoogle Scholar5. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1-12. [PMID: 8721797] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Hospital de Sabadell, CIBERehd Instituto de Salud Carlos III, Sabadell 08208, Spain.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-analysis: Duration of First-Line Proton-Pump Inhibitor–Based Triple Therapy for Helicobacter pylori Eradication Lorenzo Fuccio , Maria Eugenia Minardi , Rocco Maurizio Zagari , Diego Grilli , Nicola Magrini , and Franco Bazzoli Could Increasing the Duration of Triple Therapy Be a Clinically Useful Strategy? Lorenzo Fuccio , Rocco Maurizio Zagari , and Franco Bazzoli Metrics Cited ByOptimum duration of regimens for Helicobacter pylori eradicationGuía de práctica clínica sobre el manejo del paciente con dispepsia. Actualización 2012Guía de práctica clínica sobre el manejo del paciente con dispepsia. Actualización 2012Optimum duration of regimens for Helicobacter pylori eradicationResponse to Fuccio et al. 15 April 2008Volume 148, Issue 8Page: 624KeywordsConflicts of interestHelicobacter pylori infectionUlcers ePublished: 15 April 2008 Issue Published: 15 April 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...