tbuckley/cabot-search huggingface dataset:
Thrombotic Thrombocytopenic Purpura: Failure of Plasma Infusion and Antiplatelet Agents
Authors: RONALD STERN
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 June 1979Thrombotic Thrombocytopenic Purpura: Failure of Plasma Infusion and Antiplatelet AgentsRONALD STERN, M.D., CORNELIUS J. CORNELL JR., M.D., ROBERT BECK, M.D., ROBERT E. SMITH, M.D.RONALD STERN, M.D.Search for more papers by this author, CORNELIUS J. CORNELL JR., M.D.Search for more papers by this author, ROBERT BECK, M.D.Search for more papers by this author, ROBERT E. SMITH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-989_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Byrnes and Khurana (1) have reported the successful treatment of patients with thrombotic thrombocytopenic purpura using plasma infusions. Different promising treatments have been advocated by other authors, yet the mortality rate continues at about 70%. No regimen has been shown by controlled trials to be more effective than any other method.A 23-year-old woman with juvenile onset diabetes noted easy bruising 2 days before hospital admission for asymptomatic mild jaundice. Examination showed a temperature of 37.4 °C, petechiae and ecchymosis, mild scleral icterus, and a barely palpable nontender liver. Neurologic findings were normal. Laboratory findings included a...References1. BYRNESKHURANA JM: Treatment of thrombotic thrombocytopenic purpura with plasma. N Engl J Med 297:1386-1389, 1977 CrossrefMedlineGoogle Scholar2. BYRNESSHOLTISWHITE JCP: Plasma infusion in the treatment of thrombotic thrombocytopenic purpura, further experience (abstract). Blood 50 (suppl 1):236, 1977 Google Scholar3. LIANBYRNESKHURANASCHULTZ EJMD: A platelet aggregating substances in the plasma of a patient with thrombotic thrombocytopenic purpura (TTP) and its inhibition by a factor in normal plasma (abstract). Blood 50 (suppl 1):245, 1977 Google Scholar4. HANZLICKSHAHSENHAUSER RND: Treatments for thrombotic thrombocytopenic purpura: plasma, vincristine, hemodialysis and exchange transfusions (letter). N Engl J Med 298:971, 1978 CrossrefMedlineGoogle Scholar5. ANSELLBEASERPECHET JRL: Thrombotic thrombocytopenic purpura fails to respond to fresh frozen plasma infusion. Ann Intern Med 89:647-648, 1978 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dartmouth-Hitchcock Medical Center Hanover, NH 03755 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThrombotic thrombocytopenic purpura: Clinical results of a French controlled trialPlasma Therapy for Thrombotic Thrombocytopenic PurpuraThrombocytopenia Due to Non-immune Platelet DestructionAdverse drug reactions: special cases of chemically-induced diseases 1 June 1979Volume 90, Issue 6Page: 989-989KeywordsBlood plasmaDeath ratesLiverResearch laboratoriesTemperatureThrombotic thrombocytopenic purpura Issue Published: 1 June 1979 PDF DownloadLoading ...
Hexavalent Chromium Is Carcinogenic to F344/N Rats and B6C3F1 Mice after Chronic Oral Exposure
Authors: Matthew D. Stout, Ronald A. Herbert, Grace E. Kissling, Bradley J. Collins, Gregory S. Travlos, Kristine L. Witt, Ronald L. Melnick, Kamal M. Abdo, David E. Malarkey, Michelle J. Hooth
Journal: Environmental Health Perspectives (2008)

BackgroundHexavalent chromium [Cr(VI)] is a human carcinogen after inhalation exposure. Humans also ingest Cr(VI) from contaminated drinking water and soil; however, limited data exist on the oral toxicity and carcinogenicity of Cr(VI).ObjectiveWe characterized the chronic oral toxicity and carcinogenicity of Cr(VI) in rodents.MethodsThe National Toxicology Program (NTP) conducted 2-year drinking water studies of Cr(VI) (as sodium dichromate dihydrate) in male and female F344/N rats and B6C3F1 mice.ResultsCr(VI) exposure resulted in increased incidences of rare neoplasms of the squamous epithelium that lines the oral cavity (oral mucosa and tongue) in male and female rats, and of the epithelium lining the small intestine in male and female mice. Cr(VI) exposure did not affect survival but resulted in reduced mean body weights and water consumption, due at least in part to poor palatability of the dosed water. Cr(VI) exposure resulted in transient microcytic hypochromic anemia in rats and microcytosis in mice. Nonneoplastic lesions included diffuse epithelial hyperplasia in the duodenum and jejunum of mice and histiocytic cell infiltration in the duodenum, liver, and mesenteric and pancreatic lymph nodes of rats and mice.ConclusionsCr(VI) was carcinogenic after administration in drinking water to male and female rats and mice.
Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma
Authors: Tongsen Zheng, Xuehui Hong, Jiabei Wang, Tiemin Pei, Yingjian Liang, Dalong Yin, Ruipeng Song, Xuan Song, Zhaoyang Lu, Shuyi Qi, Jiaren Liu, Boshi Sun, Changming Xie, Shangha Pan, Yuejin Li, Xiaohe Luo, Shuai Li, Xiang Fang, Nishant Bhatta, Hongchi Jiang, Lianxin Liu
Journal: Hepatology (2013)

Although gankyrin is involved in the tumorigenicity and metastasis of some malignancies, the role of gankyrin in cholangiocarcinoma (CCA) is unclear. In this study we investigated the expression of gankyrin in human CCA tissues and cell lines. The effects of gankyrin on CCA tumor growth and metastasis were determined both in vivo and in vitro . The results showed that gankyrin was overexpressed in CCA tissues and cell lines. Gankyrin expression was associated with CCA histological differentiation, TNM stage, and metastasis. The multivariate Cox analysis revealed that gankyrin was an independent prognostic indicator for overall survival. Gankyrin overexpression promoted CCA cell proliferation, migration, and invasion, while gankyrin knockdown inhibited CCA tumor growth, metastasis, and induced Rb-dependent senescence and G 1 phase cell cycle arrest. Gankyrin increased the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and promoted the nuclear translocation of p-STAT3. Suppression of STAT3 signaling by small interfering RNA (siRNA) or STAT3 inhibitor interfered with gankyrin-mediated carcinogenesis and metastasis, while interleukin (IL)-6, a known upstream activator of STAT3, could restore the proliferation and migration of gankyrin-silenced CCA cells. The IL-6 level was decreased by gankyrin knockdown, while increased by gankyrin overexpression. Gankyrin regulated IL-6 expression by way of facilitating the phosphorylation of Rb; meanwhile, rIL-6 treatment increased the expression of gankyrin, suggesting that IL-6 was regulated by a positive feedback loop involving gankyrin in CCA. In the xenograft experiments, gankyrin overexpression accelerated tumor formation and increased tumor weight, whereas gankyrin knockdown showed the opposite effects. The in vivo spontaneous metastasis assay revealed that gankyrin promoted CCA metastasis through IL-6/STAT3 signaling pathway. Conclusion : Gankyrin is crucial for CCA carcinogenesis and metastasis by activating IL-6/STAT3 signaling pathway through down-regulating Rb protein. (HEPATOLOGY 2014;59:935–946)
THE EFFECT OF MP-809 IN DEPRESSIVE STATES: A MULTI-BLIND STUDY
Authors: H. AZIMA, DOROTHY ARTHURS, A. SILVER, FERN J. AZIMA
Journal: American Journal of Psychiatry (1962)

1. A new substance, MP-809, a tryptamine derivative, was investigated in 50 depressed patients, as compared to two other groups of 50 depressed patients receiving inert and potent placebo, in a multiblind controlled setting. 2. Clinically MP-809 had a significant (marked to moderate) antidepressant activity in 52% of all patients and in 74.1% of neurotic depressions. Statistically the results were significantly in favour of MP-809 as compared with the two placebos, and this significance reached the high level of P<0.001 in neurotic depressions. 3. Side effects were frequent but minimal in their intensity. 4. The final conclusion was that MP-809 is a potent antidepressant agent particularly in neurotic depressive states.
Clarification: doctors did not accuse Indian authorities of massaging leprosy data
Authors: Cornelius Walter
Journal: BMJ (2005)

Right to die" Legal view of right to life and death could threaten philosophy of palliative careEditor-Grayling claims that the "right to life" means quite a rich life; withholding treatment with death as the result and giving treatment that causes death are indistinguishable; and death is the ultimate analgesic. 1 Grayling also implies that the double effect is widely abused.The EC Convention for the Protection of Human Rights and Fundamental Freedoms protects against intentional deprivation of life. 2 Quality of life is not mentioned, and terminating a life at a person's request is clearly not permitted."Right to life" is perhaps a "right not to be killed," in medicine, generally relating to survival and not assisted death.However, some interpret it as giving patients a right to cardiopulmonary resuscitation regardless of the clinical circumstances 3 ; extrapolation to all potential interventions at the life-death interface could have disastrous consequences for the medical profession.Patients obviously can wish for their life to be terminated without needing to explain why, and they arguably have a right to attempt suicide.However, a right to assisted dying equates to a right that somebody else will kill or help to kill them on request-very different from withholding treatment or the double effect.Withholding treatment relates to interventions unable to produce the desired benefit. 4 In palliative care withholding treatment does not directly cause death that arises from an irreversible and unsustainable pathological burden.And death without adequate analgesia is possibly the ultimate pain for everyone.Judicious use of analgesia is an essential part of good terminal care, and, in 15 years as a doctor, I have yet to see a death attributable to deliberate analgesic overdose by a doctor.Palliative care affirms life until the moment of death, regarding death from advanced incurable disease as a natural process. 5 It aims to relieve pain and other distressing symptoms, enhance remaining quality of life, and neither hasten nor postpone death.These human "death rights" should perhaps be protected by legislation.Ill-conceived legislative changes that take the right to life or the right to death beyond sensible limits or give certain doctors the right to kill on request could jeopardise palliative care.
TCT-628 Stability Of Non Culprit Vessel Fractional Flow Reserve In Patients With ST-Segment Elevation Myocardial Infarction
Authors: David A. Wood, Rohan S. Poulter, Robert Boone, Iefan Lim, Nigussie Bogale, Andrew Starovoytov, Mathieu Lempereur, Imran Shiekh, Karin Humphries, Colum Owens, Christopher Buller, G.B. John Mancini, John Cairns, Graham C. Wong
Journal: Journal of the American College of Cardiology (2013)
Rectal stenosis caused by cytomegalovirus colitis
Authors: K. Kume, I. Yoshikawa
Journal: Endoscopy (2009)

A 87-year-old man attended our hospital for watery diarrhea since 1 week. Colonoscopy revealed multiple 3 – 6 mm superficial ulcerations in the rectum ([Fig. 1]). The ulcers were shallow and had sharp margins ([Fig. 2]). Cytomegalovirus (CMV) pp65 antigenemia assay (C7-HRP; SRL Inc, Japan) revealed many CMV-positive cells (6/1400 cells). Because CMV viremia was strongly suspected, treatment was initiated with ganciclovir. Immunohistochemistry of biopsy specimens taken from the ulcer craters revealed intranuclear inclusions that were positive for immunostaining with specific anti-CMV antibodies. After 7 days, the diarrhea ceased. At follow-up 2 months later, colonoscopy ([Fig. 3]) and barium enema ([Fig. 4]) both revealed pinpoint stenosis at the rectosigmoid junction, related to the ulcer scars. We took this to mean a cure in endoscopic terms.
WOUND OF LEFT SUBCLAVIAN ARTERY.Read before the Southeastern Kentuckv Medical Societv, at Stanford, Ky., April, 1894.
Authors: J. N. BAUGHMAN
Journal: JAMA (1894)

On the afternoon of Nov. 7, 1893, Charles Haywood, aged 19 years, was stabbed in the left side of the neck about one and one-half inches above the clavicle and about two inches from sternal end of clavicle. The knife, which was an ordinary pocket knife about three inches in length of blade, going downward, backward and inward, wounding the subclavian artery in its first division; as to the nature of the wound of the artery, we were unable to tell, but are of the opinion that the knife punctured the vessel. Dr. James Steele and myself saw the case in about two minutes after the wound was received. The red arterial blood was spurting out of the wound in a stream half as large as one's finger and to the distance of about one foot above the boy's head. He was reeling from the shock and the sudden loss
Effects of antioxidants on oxidant-induced sister chromatid exchange formation.
Authors: A B Weitberg, S A Weitzman, E P Clark, T P Stossel
Journal: Journal of Clinical Investigation (1985)

Stimulated human phagocytes produce sister chromatid exchanges in cultured mammalian cells by a mechanism involving oxygen metabolites. Experiments were designed to determine whether antioxidants inhibit this process. Superoxide dismutase, catalase, and hydroxyl radical scavengers (benzoate, mannitol) protected target Chinese hamster ovary cells from phagocyte-induced sister chromatid exchanges, implicating the involvement of hydroxyl radicals in this chromosomal damage. N-acetylcysteine and beta-carotene were also protective. alpha-Tocopherol (greater than 5 microM) protected target cells exposed to phagocytes but not to enzymatically generated oxidants when the vitamin was added just before the source of oxygen radicals, suggesting, as reported by others, that the principal action of tocopherol in this setting was to inhibit the release of oxidants from phagocytes. On the other hand, cultivation of target cells with supplemental tocopherol protected them from the toxic effects of the enzymatic oxidant-producing system, indicating a role for membrane-associated free radicals in the mechanism of sister chromatid exchange induction. Low concentrations of sodium selenite (0.1-1.0 microM) protected the target cells. However, higher concentrations (10 microM) of selenite had no effect on oxidant-induced sister chromatid exchange formation, and 0.1 mM selenite increased the number of exchanges. Sodium selenite concentrations of 0.1 mM also decreased the intracellular glutathione concentration of target cells during an oxidant stress, and reducing target cell glutathione concentrations with buthionine sulfoximine increased their sensitivity to oxygen-related chromosomal damage. Therefore, the potentiation of oxygen radical-induced chromosomal damage observed with high concentrations of selenite may result from a decrease in the thiol antioxidant defense systems within the cell. The findings suggest that the hydroxyl radical has an important role in the production of phagocyte-induced cytogenetic injury, membrane-derived intermediates may be involved, depletion of intracellular glutathione renders cells more susceptible to this injury, and supplementation of target cells with antioxidants can protect them from oxygen radical-generated chromosomal injury.
Validation of a melasma quality of life questionnaire for Brazilian Portuguese language: the MelasQoL-BP study and improvement of QoL of melasma patients after triple combination therapy
Authors: T.F. Cestari, D. Hexsel, M.L. Viegas, L. Azulay, K. Hassun, A.R.T. Almeida, V.R.P.A. Rêgo, A.M.D. Mendes, J.W.A. Filho, H. Junqueira
Journal: British Journal of Dermatology (2006)

Journal Article Validation of a melasma quality of life questionnaire for Brazilian Portuguese language: the MelasQoL‐BP study and improvement of QoL of melasma patients after triple combination therapy Get access T.F. Cestari, T.F. Cestari Department of Dermatology, Federal University of Rio Grande do Sul Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil Correspondence: Tania F. Cestari. E‐mail: tcestari@hcpa.ufrgs.br Search for other works by this author on: Oxford Academic Google Scholar D. Hexsel, D. Hexsel Dermatology Clinic Doris Hexsel, Porto Alegre, Brazil Search for other works by this author on: Oxford Academic Google Scholar M.L. Viegas, M.L. Viegas Maria de Lourdes Viegas Dermatology Clinic, Rio de Janeiro, Brazil Search for other works by this author on: Oxford Academic Google Scholar L. Azulay, L. Azulay Dermatology Center, Santa Casa de Misericordia do Rio de Janeiro, Rio de Janeiro, Brazil Search for other works by this author on: Oxford Academic Google Scholar K. Hassun, K. Hassun Cosmiatry and Surgery Division of Federal University of São Paulo, Brazil Search for other works by this author on: Oxford Academic Google Scholar A.R.T. Almeida, A.R.T. Almeida Hospital do Servidor Público Municipal de São Paulo, São Paulo, Brazil Search for other works by this author on: Oxford Academic Google Scholar V.R.P.A. Rêgo, V.R.P.A. Rêgo Hospital Universitario Prof. Edgar Santos, Salvador, Brazil Search for other works by this author on: Oxford Academic Google Scholar A.M.D. Mendes, A.M.D. Mendes Dermatology Department University of Para State, Para, Belem, Brazil Search for other works by this author on: Oxford Academic Google Scholar J.W.A. Filho, J.W.A. Filho Hospital Universitario Walter Cantidio, Federal University of Ceara, Fortaleza, Brazil Search for other works by this author on: Oxford Academic Google Scholar H. Junqueira H. Junqueira Department of Dermatology, University of Goias, Goiania, Brazil Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue s1, 1 December 2006, Pages 13–20, https://doi.org/10.1111/j.1365-2133.2006.07591.x Published: 01 December 2006
A breathless woman with asthma
Authors: R. H Thomas, C. Burke, D. Howlett
Journal: BMJ (2009)

A 36 year old housewife presented to the accident and emergency department because of increasing breathlessness, wheeze, and productive cough over the past two weeks. She had a history of asthma, which was well controlled with inhalers, but had no other history of note and was a non-smoker. On examination, she was dyspnoeic but afebrile, with a prolonged expiratory wheeze at the left base. Posteroanterior chest radiography was performed as part of her initial investigations (fig 1⇓). Fig 1 Posteroanterior chest radiograph ### Short answers
Gastric emptying of liquid in children suffering from acute rotaviral gastroenteritis.
Authors: P K Bardhan, M A Salam, A M Molla
Journal: Gut (1992)

Nausea and vomiting commonly occur in children suffering from rotaviral diarrhoea. Gastric emptying was studied in 10 children (age six to 12 months) suffering from acute diarrhoea caused by rotavirus using a dye dilution double sampling technique. The test meal was 5% dextrose in water and this test was repeated 12 weeks after recovery. The median (range) of the percentages of the liquid meal remaining in the stomach at 5, 10, 20, 40, and 60 minutes after instillation of the meal were 82 (79-90), 70 (61-86), 51 (38-76), 26 (14-53), and 13 (2-35) respectively in the acute stage, whereas after the recovery period the values were 76 (70-79), 58 (49-63), 33 (24-40), 11 (2-26), and 3 (0-7). The differences were statistically significant. The half time of gastric emptying (t1/2) was 19.5 (14-30) minutes in acute stage, and 13.1 (10-15) minutes during follow up (p less than 0.01). Rotaviral gastroenteritis is accompanied by abnormal gastric motor function, as manifested by delayed emptying of a liquid meal.
A Biochemical Basis of Multiple Sclerosis
Authors: George A. Schumacher
Journal: JAMA (1962)

As stated by the author in his preface, the primary goal of this monograph is to develop a unified hypothesis capable of explaining the known facts about multiple sclerosis. The hypothesis, based on animal experimental and clinical observations made by the author over the past 12 years, and on observations reported in the literature, is that an important contributing factor to, if not the cause of, the lesions of multiple sclerosis is the consumption of excessive fat in the diet. According to the theory proposed, such fat ingestion leads to a harmful lipemia which upsets the suspension stability of the blood, thus resulting in sludge formation with scattered vascular obstructions, hypoxia, localized impairment of the blood-brain barrier, and perivascular demyelinated areas. Virtually all evidence derived from his own and others' experiments on the effect of high-fat meals and lipemia on the blood in animals and from the analysis of blood
EARLY SURGERY VERSUS CONVENTIONAL TREATMENT FOR ASYMPTOMATIC SEVERE MITRAL REGURGITATION: A MULTICENTER COHORT STUDY
Authors: Duk-Hyun Kang, Sung-Ji Park, Byung Joo Sun, Dae-Hee Kim, Jong-Min Song, Kee-Joon Choi, Seung Woo Park, Joo-Hee Zo, Jae-Kwan Song, Jae-Won Lee
Journal: Journal of the American College of Cardiology (2014)
ANOTHER CASE OF SPOROTRICHIAL INFECTION IN MAN
Authors: G. S. Adams
Journal: JAMA (1913)

A wide-spread and growing interest in the subject of sporotrichosis during the last three years, particularly in the middle West, is evident from the increasing number of cases of this infection that are being recognized and reported. There can be little doubt that when the nature of this infection is more fully understood by the general practitioner a large number of cases of refractory skin lesions, now diagnosed as tuberculous or syphilitic in origin, will be recognized and treated as sporotrichosis. The following more or less typical example of the infection very well illustrates this
ATP-dependent effects of halothane on SR Ca regulation in permeabilized atrial myocytes
Authors: Z YANG, S HARRISON, D STEELE
Journal: Cardiovascular Research (2004)

Previous work suggests that modification of sarcoplasmic reticulum (SR) function may contribute to the cardioprotective effect of halothane during ischaemia and reperfusion. The aim of this study was to investigate the effects of halothane on spontaneous Ca(2+) release from the sarcoplasmic reticulum (Ca(2+) sparks and waves).Rat atrial myocytes were permeabilized with saponin and perfused with solutions approximating to the intracellular milieu and containing fluo-3. SR Ca(2+) release was detected using confocal microscopy.In the presence of 5 mM ATP, halothane (0.25-2 mM) had no significant effect on the amplitude or frequency of spontaneous Ca(2+) waves. However, in the presence of 0.05 mM ATP, halothane (0.25-2 mM) induced a concentration-dependent decrease in the amplitude and an increase in the frequency of spontaneous Ca(2+) waves, e.g., 1 mM halothane decreased the amplitude by 34.7+/-3.5% (n=9) and increased the frequency by 67+/-19.9% (n=7). In the presence of 5 mM ATP, 1 mM halothane had no significant effect on the amplitude or frequency of Ca(2+) sparks. When [ATP] was reduced to 0.05 mM, Ca(2+) spark frequency decreased by 67.9+/-14% and the amplitude increased by 27.5+/-4.9% (n=13). Subsequent introduction of halothane (0.5-1 mM) induced a transient burst of Ca(2+) sparks, consistent with ryanodine receptor (RyR) activation. Further experiments showed that the decrease in Ca(2+) spark frequency following ATP depletion was associated with a progressive increase in the SR Ca(2+) content over 1-2 min. This rise in SR Ca(2+) content did not occur when 1 mM halothane was present during ATP depletion.These data suggest that the sensitivity of the RyR to activation by halothane increases at low [ATP]. In metabolically impaired cells, halothane would be expected to lessen any rise in SR Ca(2+) content and to reduce the amplitude of spontaneous Ca(2+) release. These effects of halothane are considered in relation to the events that occur during ischaemia and reperfusion.