tbuckley/cabot-search huggingface dataset:
INFLUENCE OF LEFT AND RIGHT VENTRICULAR LEAD-TIP POSITION ON THE RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY: RESULTS FROM THE REVERSE STUDY
Authors: Claude Daubert, Christophe Thebault, Catherine Meunier, Renaud Gervais, Bart Gerritse, Michael R. Gold, William T. Abraham, Cecilia Linde
Journal: Journal of the American College of Cardiology (2011)
Gene Silencing in Cancer in Association with Promoter Hypermethylation
Authors: James G. Herman, Stephen B. Baylin
Journal: New England Journal of Medicine (2003)

This article reviews the mechanisms of gene silencing in cancer and clinical applications of this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key event in the development of cancer. The silencing can be effected by a disabling mutation or by a shutting down of the promoter region, the site at which transcription of the gene begins.
383. Zinc Finger Nuclease-Boosted Gene Targeting and Synergistic Transient Regenerative Stem Cell Gene Therapy: Toward Clinical Gene Repair/Alteration and Custom Site-Specific Integrative Gene Therapy
Authors: Roger Bertolotti
Journal: Molecular Therapy (2005)

A long-term stem cell gene therapy approach has been devised in which gene targeting is associated to transient regenerative gene therapy. This synergistic combination is aimed 1) at eliminating hazardous random-integration of therapeutic DNA into host chromosomes and 2) at magnifying the repopulating/regenerative ability of transfected/transduced stem cells, in particular when they are devoid of a selective growth advantage over unengineered cognates.
Locum doctor is struck off for misconduct and continued denial of wrongdoing
Authors: C. Dyer
Journal: BMJ (2014)

A locum consultant anaesthetist who put two patients’ lives at risk through “multiple basic errors” has been struck off the medical register.

Sebastian Fernando’s actions “fell short in almost all aspects” of the care of Patient A, a 72 year old man who had two cardiac arrests in February 2013 during a knee replacement operation at Leighton Hospital in Crewe, Cheshire, the Medical Practitioners Tribunal Service found.

In the case of Patient B, a morbidly …
Choice of fluids for resuscitation in children with severe infection and shock
Authors: J. A. Carcillo
Journal: BMJ (2010)

Isotonic crystalloids are advised in early, and colloids in late, resuscitation

In the linked systematic review (doi:10.1136/bmj.c4416), Akech and colleagues assessed studies that compared the use of isotonic crystalloids and colloids for fluid resuscitation in children with severe infection and shock. All of the studies were carried out in resource poor settings.1 This is an important topic because early fluid resuscitation is a mainstay of treatment for septic shock, which has a high mortality in children worldwide.2 3

One study carried out in the United States assessed mortality and functional morbidity in 5000 children who were referred to five children’s hospitals after being received in the emergency department of a community hospital.4 Shock was defined by the presence of prolonged capillary refill (>2 seconds) or hypotension, or both. The results showed that although 40% of children who were referred had shock, this was recognised as such in only 7%, and the remainder were mistakenly referred for “respiratory distress.” Outcomes were better in patients who presented at earlier stages of haemodynamic instability, and mortality was halved when these haemodynamic abnormalities were reversed in the emergency setting. Use …
Rapid screening for methicillin-resistant Staphylococcus aureus (MRSA) did not reduce MRSA acquisition rate
Authors: David A. Pegues
Journal: Annals of Internal Medicine (2008)

Source Citation Jeyaratnam D, Whitty CJ, Phillips K, et al. Impact of rapid screening tests on acquisition of meticillin resistant Staphylococcus aureus: cluster randomised crossover trial. BMJ. 20...
Acute Pancreatitis and Diabetic Ketoacidosis in Accidental Hypothermia and Hypothermic Myxoedema
Authors: D. Maclean, J. Murison, P. D. Griffiths
Journal: BMJ (1973)

Serial serum amylase and blood glucose levels were measured in 68 hypothermic (rectal temperature 35 degrees C or less) patients, including 15 who had hypothermic myxoedema (serum protein bound iodine 3.5 mug/100 ml or less). Raised amylase levels were found in 34 patients and probably reflected a mild acute pancreatitis. The high amylase levels correlated with low arterial PO(2) levels and significantly with high arterial PCO(2) levels and the base deficit but not with the severity or duration of the hypothermia. The acute pancreatitis does not explain why hypothermic patients with myxoedema have a poorer prognosis than those who are euthyroid. The pancreatitis occasionally contributed to the development, sometimes delayed, of diabetic ketoacidosis, blood glucose levels of over 120 mg/100 ml being found in 20 patients. There was a significant correlation between the raised serum amylase levels and the hyperglycaemia. Hypoglycaemia, sometimes profound, was found in 12 patients.
The Return of Cyclospora in 1997: Another Outbreak of Cyclosporiasis in North America Associated with Imported Raspberries
Authors: Barbara L. Herwaldt
Journal: Annals of Internal Medicine (1999)

In the spring of 1996, an outbreak of cyclosporiasis associated with fresh Guatemalan raspberries occurred in the United States and Canada. Another multistate outbreak of cyclosporiasis occurred in North America in the spring of 1997.To identify the vehicle of the outbreak that occurred in the spring of 1997.Retrospective cohort studies of clusters of cases associated with events (such as banquets) and traceback investigations of sources of implicated produce.United States and Canada.Persons who attended events associated with clusters of cases of cyclosporiasis.Identification of clinically defined or laboratory-confirmed cases of cyclosporiasis and risk factors for infection.41 clusters of cases were reported in association with events held from 1 April through 26 May in 13 U.S. states, the District of Columbia, and 1 Canadian province. The clusters comprised 762 cases of cyclosporiasis, 192 (25.2%) of which were laboratory confirmed. In addition, 250 laboratory-confirmed sporadic cases were reported in persons who developed gastrointestinal symptoms from April through 15 June, for a total of 1012 cases. Fresh raspberries were the only food common to all 41 events and were the only type of berry served at 9 events (22.0%). Statistically significant associations between consumption of raspberry-containing items and cyclosporiasis were documented for 15 events (40.5% of 37). For 31 of the 33 events with well-documented traceback data, the raspberries either definitely came from Guatemala (8 events) or could have come from Guatemala (23 events). The mode of contamination of the raspberries remains unknown. The outbreak ended shortly after the exportation of fresh raspberries from Guatemala was voluntarily suspended at the end of May 1997.Similar multistate, multicluster outbreaks of cyclosporiasis associated with consumption of Guatemalan raspberries have occurred in consecutive years. These outbreaks highlight the need for better understanding of the biology and epidemiology of Cyclospora cayetanensis and for stronger prevention and control measures to ensure the safety of produce eaten raw.
Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels
Authors: Patrick Deelen, Daria V Zhernakova, Mark de Haan, Marijke van der Sijde, Marc Jan Bonder, Juha Karjalainen, K Joeri van der Velde, Kristin M Abbott, Jingyuan Fu, Cisca Wijmenga, Richard J Sinke, Morris A Swertz, Lude Franke
Journal: Genome Medicine (2015)
Risk Factors for Amputation in Diabetics
Authors: Lisa G. Newman
Journal: Annals of Internal Medicine (1993)

Letters1 February 1993Risk Factors for Amputation in DiabeticsLisa G. Newman, MD and Alex Stagnaro-Green, MDLisa G. Newman, MDSearch for more papers by this author and Alex Stagnaro-Green, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-3-199302010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We congratulate Drs. Reiber and Koepnell, and the late Dr. Pecoraro on their comprehensive research describing multiple risk factors for foot amputation in diabetics [1]. However, two issues render the data difficult to interpret.First, the basis for the decision to amputate in both cases and controls with infection is critical. This is especially true for osteomyelitis, which underlies 68% of diabetic foot ulcers and for which clinical judgment is an insensitive diagnostic tool [2]. Early diagnosis and treatment of diabetic foot osteomyelitis in nongangrenous limbs in some cases could have altered group assignments by obviating the ...References1. Reiber GE, Pecoraro RE, Koepsell TD. Risk factors for amputation in patients with diabetes mellitus. Ann Intern Med. 1992; 117:97-105. Google Scholar2. Newman LG, Waller J, Palestro CJ, et al. Unsuspected osteomyelitis in diabetic foot ulcers: diagnosis and monitoring by leukocyte scanning with indium In 111 oxyquinoline. JAMA. 1991; 266:1246-50. Google Scholar3. Bamgerger DM, Daus GP, Gerding DN. Osteomyelitis in the feet of diabetic patients: long-term results, prognostic factors, and the role of antimicrobial and surgical therapy. Am J Med. 1987; 83:653-60. Google Scholar4. Pecoraro RE, Reiber GE, Burgess EM. Pathways to diabetic limb amputation. Basis for prevention. Diabetes Care. 1990; 13:513-21. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDIABETIC FOOT INFECTIONS 1 February 1993Volume 118, Issue 3Page: 231KeywordsMedical risk factorsOsteomyelitisRelative riskUlcers Issue Published: 1 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Enhancement of endothelium dependent relaxation in the rat aortic ring by selenium supplement
Authors: X. Lu, S.-Y. Liu, R. Y K Man
Journal: Cardiovascular Research (1994)

The aim was to examine the effect of selenium supplement on endothelium dependent relaxation in rat aortic rings.Rats were supplemented with selenium for 3 d (intraperitoneal injection of 4.33 mumol sodium selenite-kg1 body weight.d-1). Saline injections served as controls. Rat aortic ring was precontracted with phenylephrine and endothelium dependent relaxation was produced by the addition of acetylcholine.Acetylcholine-induced endothelium dependent relaxation was enhanced in aortic rings from rats after receiving selenium supplement as compared to control rats. For comparison, endothelium independent vasodilators (sodium nitroprusside and cromakalim) were investigated. Selenium supplement did not affect the relaxation produced by these vasodilators. N-nitro-L-arginine methyl ester (L-NAME) abolished acetylcholine induced relaxation in aortic rings from animals with selenium supplement while indomethacin had no effect on the relaxation. Direct addition of selenium or glutathione peroxidase and glutathione into the organ bath had no effect on acetylcholine induced endothelium dependent relaxation.The enhanced relaxation after selenium supplement was due to an increase in the release of nitric oxide since L-NAME was effective in blocking the relaxation. The lack of an effect by indomethacin indicated little role for cyclooxygenase products in this system. Our results suggest that the effect of selenium supplement on endothelium dependent relaxation is mediated by cellular changes that cannot be mimicked by the direct addition of selenium or the selenium dependent enzyme glutathione peroxidase.
Rational Design of Multifunctional Hetero‐Hexameric Proteins for Hydrogel Formation and Controlled Delivery of Bioactive Molecules
Authors: Xiaoli Zhang, Hao Zhou, Ying Xie, Chunhua Ren, Dan Ding, Jiafu Long, Zhimou Yang
Journal: Advanced Healthcare Materials (2014)

A hetero‐hexameric protein system is developed in this study, which not only functions as cross‐linkers for hydrogel formation but also offers docking sites for controlled delivery of bioactive molecules. First, a hexameric protein with two, four, and six tax‐interacting protein‐1 (TIP‐1), respectively (named as 2T, 4T, and 6T), is designed and obtained. As the hexapeptide ligand (WRESAI) can specifically bind to TIP‐1 with high affinity, the hexameric proteins of 2T, 4T, and 6T can be used to crosslink the self‐assembling nanofibers of Nap‐GFFYGGGWRESAI, leading to formation of injectable biohybrid hydrogels with tunable mechanical properties. Furthermore, a hetero‐hexameric protein containing four TIP‐1 and two C‐terminal moiety of the pneumococcal cell‐wall amidase LytA (C‐LytA) proteins is designed and engineered (named as 4T2C). The 4T2C proteins can not only serve as cross‐linkers for hydrogel formation but also provide docking sites for loading and controlled release of model drug Rhoda‐GGK′. This study opens up new opportunities for further development of multifunctional hetero‐ recombinant protein‐based hydrogels for biological applications.
VASCULAR COMPLICATIONS FOLLOWING TRANSCATHETER AORTIC VALVE IMPLANTATION WITH BOTH EDWARDS SAPIEN AND MEDTRONIC COREVALVE(R) BIOPROSTHESIS USING TRANSFEMORAL APPROACH SUPPORTED BY THE CROSS-OVER TECHNIQUE
Authors: Cosmo Godino, Marco Mussardo, Alfonso Ielasi, Micaela Cioni, Matteo Montorfano, Francesco Maisano, Alaide Chieffo, Azeem Latib, Patrizia Carità, Francesco Arioli, Maurizio Taramasso, Irina Arendar, Paolo Denti, Andrea Giacomini, Pietro Spagnolo, Giovanni La Canna, Ottavio Alfieri
Journal: Journal of the American College of Cardiology (2011)
Laser Radiation for Metastatic Malignant Melanoma
Authors: Paul E. McGuff
Journal: JAMA (1966)

THIS REPORT is that of a 46-year-old white woman of Irish ancestry, whom I first saw in October 1964, whose left thigh revealed on its anterior and medial surfaces multiple malignant metastatic melanoma. These presented as approximately 200 verrucous, blackish-brown lesions, ranging in size from 2 mm to 2.2 cm. At the lower end of an inguinal scar, there was a firm, discrete, 4.0 × 3.3 × 3.1-cm subcutaneous mass. The clinical impression was multiple metastatic malignant melanoma, recurrent, with widespread involvement of the left thigh, inguinal area, and with a possible large inguinal melanotic mass. <h3>Report of a Case</h3> In April 1963, the patient had a wide excision elsewhere of a black mole from the left lateral aspect of the lower one third of the leg, with a pathological diagnosis of malignant melanoma. This was radically excised, and a skin graft was applied. A radical left-groin dissection was performed
Persistent airflow obstruction in asthma of patients with Churg–Strauss syndrome and long‐term follow‐up
Authors: V. Cottin, C. Khouatra, R. Dubost, J ‐C. Glérant, J ‐F. Cordier
Journal: Allergy (2009)

Little is known about the long-term outcome of airflow obstruction in asthma of patients with Churg-Strauss syndrome (CSS).We conducted a retrospective study of 24 consecutive patients (aged 41.1 +/- 13.5 years) with CSS in a single center. All had asthma (starting 8.1 +/- 9.5 years prior to the diagnosis of CSS), blood eosinophilia (6.1 +/- 4.4 x 10(9)/l) and systemic manifestations of CSS. Antineutrophil cytoplasmic antibodies were found in 7 of 22 tested patients. Seven patients had smoked (a mean of 10 pack-years). All patients received oral corticosteroids, 11 cyclophosphamide and 23 inhaled corticosteroids.Airflow obstruction was found in 14 patients (70%) at diagnosis, and in 11 of 22 patients (50%) at the time of the clinical remission of CSS. The mean postbronchodilator FEV1/FVC and FEV1 were 69 +/- 12% and 74 +/- 21% of predicted at diagnosis (n = 20); 71 +/- 10% and 92 +/- 19% of predicted at the clinical remission (n = 22); and 64 +/- 13% and 80 +/- 21% at last visit (n = 13), respectively. During follow-up, postbronchodilator FEV1 increased by 30 +/- 28% in six patients with FEV1/FVC < 70% despite inhaled therapy who received higher dose of oral corticosteroids. At last visit, 5 of 13 patients (38%) with more than 3 years of follow-up had persistent airflow obstruction as defined by postbronchodilator FEV1/FVC < 70% and FEV1 < 80% of predicted.Airflow obstruction due to uncontrolled asthma is present despite corticosteroids in many patients at diagnosis and at clinical remission of CSS, and during follow-up. It may be still partly reversible with increased oral corticosteroid treatment.
Enhanced silencing and stabilization of siRNA polyplexes by histidine-mediated hydrogen bonds
Authors: Szu-Ting Chou, Kellie Hom, Daoning Zhang, Qixin Leng, Lucas J. Tricoli, Jason M. Hustedt, Amy Lee, Michael J. Shapiro, Joonil Seog, Jason D. Kahn, A. James Mixson
Journal: Biomaterials (2013)
German health system makes 3.9bn surplus in first three quarters of 2011
Authors: N. Stafford
Journal: BMJ (2011)

German’s public health insurance system, made up of independent insurers regulated by the government and covering nearly 90% of the population, has recorded a surplus of €3.9bn (£3.3bn; $5.2bn) in the first nine months of 2011, says the German health ministry. The surplus in the same period in 2010 was €277m.

In a statement issued on 6 December on public health insurance “financial developments,” the ministry said that insurers spent €133.8bn in the first nine months of 2011 and collected €137.7bn in premiums. Mandatory monthly premiums for workers now stand at 15.5% of gross wages, often referred to as a payroll tax in Germany, with the cost split between employees and …
The Johns Hopkins Manual of Cardiothoracic Surgery
Authors: Irving L. Kron
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Occupational Exposure to Radiation on the Mortality of Physicians
Authors: Raymond Seltser, Philip E. Sartzvell
Journal: JAMA (1964)

Does occupational exposure to x-rays on the part of radiologists shorten their lives? It has long been known that sublethal acute or chronic exposure of laboratory animals to ionizing radiation will do so. On the basis of observed average age at death, a life-shortening effect in radiologists has been postulated. This paper will summarize some observations designed to answer this question more definitely. A much more complete analysis of the data will appear in the<i>American Journal of Epidemiology</i>(formerly the<i>American Journal of Hygiene</i>) for January, 1965. Three medical specialty societies were chosen on the basis of amount of presumed average exposure of their members to x-rays in the course of their professional activities. Other criteria in selection of societies were size of the organization, the duration of its existence, and the availablity of needed records. The societies chosen, in order of presumed diminishing exposure were: the Radiological Society
Single dose versus daily intravenous aminohydroxypropylidene biphosphonate (APD) for the hypercalcaemia of malignancy
Authors: A R Morton, J A Cantrill, A E Craig, A Howell, M Davies, D C Anderson
Journal: BMJ (1988)

Thirty patients with hypercalcaemia and known malignant disease were randomly allocated to receive 60 mg 3-amino-1-hydroxypropylidene-1, 1-bisphosphonate (APD) intravenously as a single dose or as consecutive daily doses of 30 mg (two days) or 15 mg (four days). The rate of infusion was the same for each regimen (7.5 mg/hour). Calcium concentrations fell in all patients and returned to normal in all but two. Relapse of hypercalcaemia occurred after a mean of 21 days in each group. Urinary calcium excretion fell in all groups and symptoms were greatly improved. After relapse patients were retreated with APD (30 mg as a single infusion) and normocalcaemia maintained by regular infusions at two to three week intervals. APD given as a single 60 mg infusion over eight hours together with rehydration is recommended as the initial management of the hypercalcaemia of malignancy, followed by 30 mg APD roughly every two to three weeks to maintain normal or near normal serum calcium concentrations.
Aspirin-Induced Hepatotoxicity in Patients with Systemic Lupus Erythematosus
Authors: WILLIAM E. SEAMAN
Journal: Annals of Internal Medicine (1974)

Three patients with systemic lupus erythematosus were noted to have evidence of liver injury that proved to be related to aspirin therapy. In two of the patients, the initial presentation mimicked chronic active hepatitis. A liver biopsy obtained from one of the patients was also consistent with the diagnosis of chronic active hepatitis, and the biopsy from a second patient showed acute hepatocellular injury. Aspirin should be considered among causes of hepatitis, particularly in patients with lupus erythematosus.
Increasing Survival of Ischemic Tissue by Targeting CD47
Authors: Jeff S. Isenberg, Martin J. Romeo, Mones Abu-Asab, Maria Tsokos, Anna Oldenborg, Loretta Pappan, David A. Wink, William A. Frazier, David D. Roberts
Journal: Circulation Research (2007)

Thrombospondin-1 (TSP1) limits the angiogenic and vasodilator activities of NO. This activity of TSP1 can be beneficial in some disease states, but endogenous TSP1 limits recovery of tissue perfusion following fixed ischemic injury in dorsal skin flaps in mice. Using mice lacking the TSP1 receptors CD36 or CD47, we now show that CD47 is the necessary receptor for limiting NO-mediated vascular smooth muscle relaxation and tissue survival following ischemic injury in skin flaps and hindlimbs. We further show that blocking CD47 or TSP1 using monoclonal antibodies and decreasing CD47 expression using an antisense morpholino oligonucleotide are effective therapeutic approaches to dramatically increase survival of soft tissue subjected to fixed ischemia. These treatments facilitate rapid vascular remodeling to restore tissue perfusion and increase skin and muscle viability. Thus, limiting CD47-dependent antagonism of NO-mediated vasodilation and vascular remodeling is a promising therapeutic modality to preserve tissues subject to ischemic stress.