tbuckley/cabot-search huggingface dataset:
Combined anatomical and radiological study of the hip-joint in alcaptonuric arthropathy.
Authors: U Steiger, R Lagier
Journal: Annals of the Rheumatic Diseases (1972)

In two patients with alcaptonuric arthropathy, we have had the opportunity of investigating three femoral heads which had been surgically removed to be replaced by a total prosthesis.This allowed us to study the osteoarthrotic remodelling of epiphyses in which damaged cartilage is labelled by pigment.This exceptional condition facilitates study of the fate of this cartilage among newly-formed tissues. Case reportsCase 1, a 64-year-old woman, was one of four cases of ochronosis in a family of nine siblings which one of us has previously reported (Steiger, 1963).The course of the disease and the clinical and x-ray findings in all affected siblings were characteristic and in accordance with the literature (Cervenansky, Sitaj, and Urbanek, 1959; O'Brien, Banfield, and Sokoloff, 1961).The hip-joints ofthis patient appeared normal by clinical and radiological examination until March, 1967, when she suffered an acute onset of severe pain in the right hipjoint.On March 8 an x-ray examination showed narrowing of the joint space with complete obliteration by April 21, and severe destruction of the articular surfaces without appreciable osteophytic reaction in September (Fig. 1).
Ill Health in Two Contrasting Societies, Particularly Non-psychiatric Morbidity among Those with a Psychiatric Diagnosis
Authors: Tom Andersen
Journal: Psychotherapy and Psychosomatics (1979)

An epidemiological study in two culturally contrasting north-norwegian societies indicates that persons with a psychiatric diagnosis are more prone to non-psychiatric illnesses than those without such diagnosis. The onset of the non-psychiatric ailments of these persons come mostly before the onset of their psychiatric conditions. These are cross-cultural findings.
Physiological profiles of young boys training in ballet.
Authors: H Pekkarinen, H Litmanen, S Mahlamäki
Journal: British Journal of Sports Medicine (1989)

In order to evaluate physiological characteristics in young male ballet dancers, 27 boys (aged 9 to 16 years) who participated in a boys' dance course during the Kuopio Dance and Music Festival in June 1988 were studied. In general, the boys had started dancing at the age of 8.6 years and had been training for 4.1 years. They had, on average, three dancing sessions per week and the mean time spent on dancing was four hours per week. In the study, some anthropometric measurements were taken, the maximal oxygen uptake (VO2 max) was measured by a cycle ergometer test and the explosive strength and the mechanical power of lower extremities were evaluated by a jumping test. The results indicate that boys who train in ballet are in general moderately lean, have relatively small body size and a high degree of flexibility. The younger boys especially have only moderate aerobic power, but both explosive strength and mechanical power in leg muscles are good in ballet trained boys.
A Patient With a Paced Rhythm Presenting With Chest Pain and Hypotension
Authors: Sarah G. Schaaf, Jeffrey A. Tabas, Stephen W. Smith
Journal: JAMA Internal Medicine (2013)

An86-year-oldwomanarrived intheemergencydepartmentcom-plainingof1hourofchestpain.Shehadahistoryofmyocardialin-farction(MI),atrialfibrillation,placementofadual-chamberpace-maker,stroke,gout,andhypertension.Onarrival,herbloodpressurewas88/68mmHg,heartratewas75beats/minandirregular,respirationswere22/min,andbloodoxy-gen saturation was 97% with 2 L/min supplemental oxygen. Shelookeduncomfortableandhadnoappreciablejugularvenousdis-tention,noabnormalheartsounds,clearlungfields,tracelowerex-tremityedema,andweakradialpulses.Thebloodlactatelevelwas4.0mg/dL(referencevalue,<2.3mg/dL)(toconverttomillimolesper liter, multiply by 0.111). A chest radiograph was normal exceptforpacemakerleadsintheexpectedpositionsandanenlargedcar-diacsilhouette.Anelectrocardiogram(ECG)wasobtained(Figure1).Question: Should this patient be taken for emergent cardiaccatheterizationformanagementofsuspectedacuteMI?
Intraluminal endoscopic vacuum therapy in a case of ischemia of the blind end of the jejunal loop after Roux-en-Y gastrectomy
Authors: Gunnar Loske, Tobias Schorsch, Henning Schmidt-Seithe, Christian Müller
Journal: Endoscopy (2014)

A 43-year-old man underwent a transhiatal gastrectomy and distal esophageal resection because of adenocarcinoma of the gastroesophageal junction (ypT3, ypN0, R0). Esophagojejunostomy was performed with an end-to-side Roux-en-Y stapled anastomosis. The jejunum was shortened using a linear stapler. On postoperative day 3, increasing inflammatory parameters C-reactive protein (CRP) 310 mg/l) prompted an endoscopic examination. We found an intact esophagojejunal anastomosis with good perfusion without leakage, but also ischemia at the blind end of the jejunum ([Fig. 1]).
Bronchial carcinoma with pleural spread causing unilateral thoracic hyperhidrosis.
Authors: W G Middleton
Journal: BMJ (1976)

and liver enzymes were normal.Patch tests for Quinaband gave negative results.Application of Quinaband was stopped, and on 24 November 2 units of fresh blood produced a rapid rise in platelet count, which subsequently returned to normal values.The patient made an excellent recovery and remained euthyroid, though the leg ulcers posed considerable problems.
Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses
Authors: Angela C. Bradshaw, Lynda Coughlan, Ashley M. Miller, Raul Alba, Nico van Rooijen, Stuart A. Nicklin, Andrew H. Baker
Journal: Journal of Controlled Release (2012)

The use of adenovirus serotype 5 (Ad5) vectors in the clinical setting is severely hampered by the profound liver tropism observed after intravascular delivery coupled with the pronounced inflammatory and innate immune response elicited by these vectors. Liver transduction by circulating Ad5 virions is mediated by a high-affinity interaction between the capsid hexon protein and blood coagulation factor X (FX), whilst penton-α(v)integrin interactions are thought to contribute to the induction of anti-Ad5 inflammatory and innate immune responses. To overcome these limitations, we sought to develop and characterise for the first time novel Ad5 vectors possessing mutations ablating both hexon:FX and penton:integrin interactions. As expected, intravascular administration of the FX binding-ablated Ad5HVR5*HVR7*E451Q vector (AdT*) resulted in significantly reduced liver transduction in vivo compared to Ad5. In macrophage-depleted mice, increased spleen uptake of AdT* was accompanied by an elevation in the levels of several inflammatory mediators. However ablation of the penton RGD motif in the AdT* vector background (AdT*RGE) resulted in a significant 5-fold reduction in spleen uptake and attenuated the antiviral inflammatory response. A reduction in spleen uptake and inflammatory activation was also observed in animals after intravascular administration of Ad5RGE compared to the parental Ad5 vector, with reduced co-localisation of the viral beta-galactosidase transgene with MAdCAM-1+ sinus-lining endothelial cells. Our detailed assessment of these novel adenoviruses indicates that penton base RGE mutation in combination with FX binding-ablation may be a viable strategy to attenuate the undesired liver uptake and pro-inflammatory responses to Ad5 vectors after intravascular delivery.
Are the dangers of childhood food allergy exaggerated?
Authors: Allan Colver
Journal: BMJ (2006)

<i>The numbers of deaths from food allergy are small and not all are preventable. Allan Colver believes that the increasing prescription of emergency prophylaxis to children fuels anxiety rather than saving lives, but Jonathan Hourihane argues that there are no data to show that prescription of autoinjectors increases anxiety and their provision, as part of an integrated care plan, is justified</i>
Thallium/Technetium Functional Imaging of the Thyroid and Parathyroid A Case Report
Authors: HARVEY A. ZIESSMAN, FREDERIC H. FAHEY, THOMAS C. LEE, RICHARD C. EASTMAN, HAROLD A. GOLDSTEIN
Journal: Clinical Nuclear Medicine (1985)

This case report demonstrates the usefulness and limitations of technetium/thallium scintigraphy in the diagnosis of parathyroid hyperplasia. In addition, discordant thyroid tracer uptake (Tc-99m but not Tl-201) due to colloid cysts is described. Another perspective in the controversy over which radiopharmaceutical, Tc-99m or Tl-201, should be injected first also is presented.
Control of Breast Cancer Through Mass Screening
Authors: Donald J. Ferguson
Journal: JAMA (1980)

Are the breast cancers found by screening more curable than the others, or are they merely diagnosed earlier? What is the cost of discovering a curable cancer by institutional mass screening? These are among the questions addressed by the 20 authorities contributing to this monograph. In addition to chapters on the rationale for mass screening, there are groups of chapters on etiologic factors related to risk, and on methods, management, and motivation. The concept of screening has engendered four decades of sustained effort toward self-examination by patients, education of physicians, and setting up of detection centers in which "mass screening" of asymptomatic women takes place. Has there been a concomitant reduction in mortality from breast cancer? Apparently diverse opinions are expressed in this book, where the distinction is not always clearly made between the mortality from breast cancer in all adult women and that in the subgroup with the disease.
Preoperative sCD40L Levels Predict Risk of Atrial Fibrillation After Off-Pump Coronary Artery Bypass Graft Surgery
Authors: Charalambos Antoniades, Tim Van-Assche, Cheerag Shirodaria, Jonathan Diesch, Alexios S. Antonopoulos, Justin Lee, Colin Cunnington, Dimitris Tousoulis, Christodoulos Stefanadis, Barbara Casadei, David Taggart, Keith M. Channon, Paul Leeson
Journal: Circulation (2009)

The risk of atrial fibrillation (AF) after coronary bypass surgery has been related to redox state, inflammation, and ischemia. Platelet activation is common to all of these pathways. We investigated the relation between AF and preoperative soluble CD40 ligand (sCD40L), a proinflammatory marker released by activated platelets. Furthermore, we studied the role of inflammation, endothelial function, and redox state in this relation.sCD40L levels were measured in 144 patients in sinus rhythm the day before off-pump coronary artery surgery. Systemic inflammation was assessed from levels of C-reactive protein and soluble intercellular adhesion molecule-1, and endothelial function was assessed from the brachial artery flow-mediated dilatation response. Graft samples were collected during surgery to assess vascular redox state. AF occurred in 33% of patients after surgery, with 3% still in AF after 6 weeks. Preoperative sCD40L levels were significantly higher in those who developed in-hospital AF (odds ratio for a 1-SD increase in log[sCD40L]=1.97; 95% CI, 1.21 to 3.22; P=0.007; after adjustment for age, sex, Euroscore, and total duration of operation). sCD40L and vascular superoxide levels were higher in patients still in AF at 6 weeks, and endothelial function was lower, although the small number of events precluded statistical analysis in this group. Systemic endothelial function, redox state, and preoperative markers of systemic inflammation were not associated with in-hospital postoperative AF.Preoperative platelet activation, as assessed by sCD40L levels, is a novel predictor of postoperative AF, independent of systemic endothelial function, vascular redox state, and systemic inflammation.
LIGHT TREATMENT IN TUBERCULOSIS
Authors: T. G. Millar
Journal: BMJ (1935)

Ultra-violet treatment of tuberculous laryngitis needs no introduction to laryngologists who have visited Continental clinics.Many of us in Melbourne were impressed by the work of Cemach and Wessely in Vienna, though we con- sidered that the eIaborate apparatus used by them was out of the question in this city.Having tried a Kromayer lamp for another purpose, I eventually found a suitable applicator, which could be introduced without discomfort to the patient, whilst at the same time giving efficieint irradiation.
P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse
Authors: Sunil Iyengar, Andrew Clear, Csaba Bödör, Lenushka Maharaj, Abigail Lee, Maria Calaminici, Janet Matthews, Sameena Iqbal, Rebecca Auer, John Gribben, Simon Joel
Journal: Blood (2013)
The Smell of Gardenias
Authors: Charles A. Koller
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Private practice within the NHS
Authors: D. Gullick
Journal: BMJ (1984)

oldest case of fibrolamellar hepatoma to be reported.Her serum B12 concentration was actually low (96 pmol/l (130 ng/l); normal range 147-737 pmol/l (200-1000 ng/l)) al- though the binding capacity was not measured.We have showed that measurement of urinary dopa metabolites may be misleading, that fibrolamellar hepatocellular carcinoma is not confined to the young, and that thorough investigation of a mass in the liver of a 65 year old is always necessary.
Androgens stimulate proteoglycan biosynthesis in human vascular smooth muscle cells: Implications for the role of androgens in atherogenesis
Authors: Kazuhiko Hashimura, Peter J. Little, Shanhong Ling, Julie Nigro, Maro R. Williams, Aozhi Dai, Paul A. Komesaroff, Krishnankutty Sudhir
Journal: Journal of the American College of Cardiology (2003)
Viral load and clinicopathological features of chronic hepatitis C (1b) in a homogeneous patient population
Authors: Liam Fanning, Elizabeth Kenny, Margaret Sheehan, Bridin Cannon, Michael Whelton, Joe O'Connell, Kevin J. Collins, Fergus Shanahan
Journal: Hepatology (1999)

Monitoring the progression of hepatitis C virus (HCV) includes clinical, biochemical, and histological parameters. Quantitation of viral load by reverse-transcription polymerase chain reaction (RT-PCR) may offer a more reliable marker of disease status. Conflicting reports on viral titers may reflect heterogeneity of patient population, mode of infection, and viral type/subtype. The aim of this study was to correlate quantitative serum viral load with alanine transaminase (ALT) and histological status in a homogenous population. The study population consisted of 77 Rhesus-negative women with chronic hepatitis C type 1b. Homogenous features of this study population included: same defined source of infection (contaminated anti-D immunoglobulin); same duration of disease (17 years at the time of study); same viral type/subtype; same ethnic origin; all healthy child-bearing females at the time of infection; and an absence of competing risk factors for infectious and other liver diseases. None of the patients had received antiviral treatment at the time of study. Liver biopsy was performed on all patients. All biopsies were scored by a single histopathologist who was blinded to the clinical and viral status of each patient. A weak, but statistically significant, correlation (rs =.26; P <.05) between serum viral load and the degree of inflammation (mean value: 3.87 +/- 2.17 [SD]) was found. There was no significant correlation between serum viral load and the degree of fibrosis (mean value: 0.84 +/- 0.8 [SD]; P =.06). There was no significant correlation between serum viral load and ALT, although there was a correlation between ALT and the degree of inflammation (rs =.241; P =.035).
Th2‐like cytokine activity in dermatitis herpetiformis
Authors: None Caproni, None Feliciani, None Fuligni, None Salvatore, None Atani, None Bianchi, None Mohammad Pour, None Proietto, None Toto, None Coscione, None Amerio, None Fabbri
Journal: British Journal of Dermatology (1998)

Dermatitis herpetiformis (DH) is a chronic subepidermal blistering disease, in which a perivascular cellular infiltrate, composed mainly of CD4+ T lymphocytes together with a varying number of neutrophils and eosinophils, is thought to be important in the pathogenesis of blister formation. The aim of this study was to investigate the potential role of cytokines such as the interleukins IL-4 and IL-5 and to quantify the distribution of T cells as well as their state of activation using alkaline phosphatase-antialkaline phosphatase and reverse transcriptase-polymerase chain reaction (RT-PCR) procedures in seven patients with typical clinical and histological features of DH. A strong extracellular staining with anti-IL-4 monoclonal antibody was detected in the upper dermis with a prevalent perivascular pattern in perilesional areas, whereas in the dermal-epidermal separation sites there was an intense, scattered distribution. IL-5 was intensely expressed, mainly at the intracellular level, by eosinophils and lymphocytes. Concerning RT-PCR, five DH patients showed a strong positive signal for both IL-4 and IL-5 cytokines while two patients showed a faint signal for both IL-4 and IL-5; these last two cases were histologically poor in inflammatory cells. In view of these results, it can be hypothesized that the recruitment of eosinophils and neutrophils in DH may be induced not only by granulocyte macrophage colony-stimulating factor and IL-8 as previously demonstrated, but also by Th2 cytokines as well.
Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines
Authors: Jun Guo, Hamid Massaeli, Jianmin Xu, Zongchao Jia, Jeffrey T. Wigle, Nasrin Mesaeli, Shetuan Zhang
Journal: Journal of Clinical Investigation (2009)

Although the modulation of ion channel gating by hormones and drugs has been extensively studied, much less is known about how cell surface ion channel expression levels are regulated. Here, we demonstrate that the cell surface density of both the heterologously expressed K+ channel encoded by the human ether-a-go-go-related gene (HERG) and its native counterpart, the rapidly activating delayed rectifier K+ channel (IKr), in rabbit hearts in vivo is precisely controlled by extracellular K+ concentration ([K+]o) within a physiologically relevant range. Reduction of [K+]o led to accelerated internalization and degradation of HERG channels within hours. Confocal analysis revealed colocalization between HERG and ubiquitin during the process of HERG internalization, and overexpression of ubiquitin facilitated HERG degradation under low [K+]o. The HERG channels colocalized with a marker of multivesicular bodies during internalization, and the internalized HERG channels were targeted to lysosomes. Our results provide the first evidence to our knowledge that the cell surface density of a voltage-gated K+ channel, HERG, is regulated by a biological factor, extracellular K+. Because hypokalemia is known to exacerbate long QT syndrome (LQTS) and Torsades de pointes tachyarrhythmias, our findings provide a potential mechanistic link between hypokalemia and LQTS.
Abstract 3771: Establishment of primary cultures of cancer stem cells from patients with Li-Fraumeni Syndrome, carrier of TP53 p.R337H Brazilian founder mutation.
Authors: Lisley I. Mambelli, Irina Kerkis, Pierre Hainaut, Maria Isabel W. Achatz
Journal: Cancer Research (2013)

Abstract Li-Fraumeni syndrome (LFS), an inherited cancer predisposition syndrome, is associated with germline mutations in TP53. It is characterized by high risk of multiple, early cancers. In Brazil, a variant form of LFS is exceedingly frequent due to a widespread founder TP53 mutation, p.R337H, detected in about 0.3% of the general population in Southern Brazil. This mutation occurs in p53 oligomerization domain and its effect on p53 oligomerization is supposed to be dependent upon pH conditions. Recent studies indicate that p53 plays a critical role in regulating differentiation and asymmetric divisions of stem cells. The main objective of this study is to isolate and to characterize Cancer Stem Cells (CSC) in patients with germline mutations in TP53 gene with Li-Fraumeni syndrome and Li-Fraumeni-like Syndrome. We have isolated and characterized CSC from tumors of p.R337H mutation carriers. After informed consent, surgical resection fragments were dissociated and brought in culture. Adherent cells and spheroids were derived from different tumor types. Spheroids and stromal cells derived from a breast cancer (BC) were further analyzed by immunofluorescence and flow cytometry to demonstrate positive immunolabeling for CD44+, CD24−, Oct4, Ki67 and Sox2 antibodies. Time-lapse videomicroscopy showed rapid growth, frequent asymmetric division and absence of senescent phenotypes for least 17 passages. Moreover, we showed by Colony Forming Units assay (CFU) that stromal cells are very clonogenic, once 103 cells initially plated were able to form 442 new colonies after 15 days in culture. It was also verified the differentiation potential of stromal cells for the following lineages: adipogenic, osteogenic and muscle-like cells. The adherent stromal cells as well as oncoesferas are able to self-renew and to proliferate in vitro for long periods without losing its main features. These properties are similar to stem cell possessing the p53 inactive. However, we observed that treatment of adherent cells with doxorubicin (DNA damaging agent) causes accumulation of p53 and causing induction of cell cycle arrest with low doses of this drug, and cell death / apoptosis in higher doses. Our findings using CSC-p.R337H can provide a very useful model for better understanding the role of specific mutation, as well as the TP53 tumor biology. Citation Format: Lisley I. Mambelli, Irina Kerkis, Pierre Hainaut, Maria Isabel W. Achatz. Establishment of primary cultures of cancer stem cells from patients with Li-Fraumeni Syndrome, carrier of TP53 p.R337H Brazilian founder mutation. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3771. doi:10.1158/1538-7445.AM2013-3771
Neutropenia and Thrombocytopenia in Renal Allograft Recipients Treated with Trimethoprim-Sulfamethoxazole
Authors: PETER P. BRADLEY
Journal: Annals of Internal Medicine (1980)

Hematologic toxicity occurred when trimethoprim-sulfamethoxazole was given for prolonged periods to renal allograft subjects also treated with azathioprine. In six such patients, the incidences and duration of neutropenia and thrombocytopenia were greater than in 25 similar allograft recipients treated with azathioprine alone. In bone marrow culture, the antifolate action of trimethoprim-sulfamethoxazole enhanced the marrow-suppressive effect of 6-mercaptopurine, the active moiety cleaved from azathioprine. These studies show that in renal allograft recipients treated with azathioprine, the prolonged use of trimethoprim-sulfamethoxazole may result in life-threatening hematotoxicity.