Lipids, Lipoproteins, Apolipoproteins, and Atherosclerosis
Authors: ROBERT A. KREISBERG
Journal: Annals of Internal Medicine (1983)

Editorials1 November 1983Lipids, Lipoproteins, Apolipoproteins, and AtherosclerosisROBERT A. KREISBERG, M.D.ROBERT A. KREISBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-5-713 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe sequence in the title conveys the evolution of our sophistication and understanding of lipids and coronary heart disease. In the beginning, the best that could be done was to measure the plasma cholesterol and triglyceride concentrations. The relation between plasma cholesterol concentration and the risk of ischemic heart disease was established using this simple approach. Fractionation of the serum cholesterol into its components has further clarified that low-density lipoprotein (LDL) cholesterol is responsible for atherogenesis. Approximately 70% of the total serum cholesterol is transported by LDL, and increases in the plasma cholesterol concentration usually represent an increase in this...References1. HAVEL R. Approach to the patient with hyperlipidemia. Med Clin North Am. 1982;66:319-34. CrossrefMedlineGoogle Scholar2. BREWER H, Introduction, pp. 623-5. In: BREWER HB, moderator. Type III hyperlipoproteinemia: diagnosis, molecular defects, pathology, and treatment. Ann Intern Med. 1983;98(5 pt 1):623-40. LinkGoogle Scholar3. STOCKSHOLDSWORTHGALTON JGD. Hypertriglyceridemia associated with an abnormal triglyceride-rich lipoprotein carrying excess apolipoprotein C-III-2. Lancet. 1979;2:667-71. CrossrefMedlineGoogle Scholar4. BASUHOBROWNBILHEIMERANDERSONGOLDSTEIN SYMDRJ. Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes. J Biol Chem. 1982;257:9788-95. CrossrefMedlineGoogle Scholar5. SHORESALENCHENG VGF. Abnormal high density lipoproteins in cerebrotendinous xanthomatosis. J Clin Invest. 1981;68:1295-304. CrossrefMedlineGoogle Scholar6. ABRAMSGRUNDYKANECHANG JSJC. Normocholesterolemic dysbetalipoproteinemia with xanthomatosis. Metabolism. 1979;28:113-24. CrossrefMedlineGoogle Scholar7. VEGAILLINGWORTHGRUNDYLINDGRENCONNOR GRSFW. Normocholesterolemic tendon xanthomatosis with overproduction of apolipoprotein B. Metabolism. 1983;32:118-25. CrossrefMedlineGoogle Scholar8. DOUSTE-BLAZYMARCELCOHENGIROUXDAVIGNON PYLJJ. Increased frequency of apo E-ND phenotype and hyperapobeta-lipoproteinemia in normolipidemic subjects with xanthelasmas of the eyelids. Ann Intern Med. 1982;96:164-9. LinkGoogle Scholar9. KESANIEMIGRUNDY YS. Overproduction of low density lipoproteins associated with coronary heart disease. Arteriosclerosis. 1983;3:40-6. CrossrefMedlineGoogle Scholar10. KISSEBAHALFARSIEVANSADAMS ASDP. Plasma low density lipoprotein transport kinetics in noninsulin-dependent diabetes mellitus. J Clin Invest. 1983;71:655-67. CrossrefMedlineGoogle Scholar11. SNIDERMANWOLFSONTENGFRANKLINBACHORIKKWITEROVICH ACBFPP. Association of hyperapobetalipoproteinemia with endogenous hypertriglyceridemia and atherosclerosis. Ann Intern Med. 1982;97:833-9. LinkGoogle Scholar12. KISSEBAHALFARSIADAMS ASP. Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein-B kinetics in man: normolipemic subjects, familial hypertriglyceridemia and familial combined hyperlipidemia. Metabolism. 1981;30:856-68. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of South Alabama Mobile, Alabama PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLipoproteins and apolipoproteins in pericardial fluid: new postmortem markers for coronary atherosclerosisA receptor assay for serum low density lipoprotein-apolipoprotein B-100: Preliminary reportPostprandial Effect of a High Fat Meal on Plasma Lipid, Lipoprotein Cholesterol and Apolipoprotein MeasurementsThe roles of apolipoproteins B and E in lipid transport and atherosclerosis 1 November 1983Volume 99, Issue 5Page: 713-715KeywordsAtherosclerosisAttentionBlood plasmaCardiovascular therapyChemical fractionationCholesterolCoronary heart diseaseLipidsLipoproteinsLow density lipoprotein Issue Published: 1 November 1983 PDF DownloadLoading ...