tbuckley/cabot-search huggingface dataset:
Effect of angina on the left ventricular diastolic pressure-volume relationship.
Authors: T Mann, B R Brodie, W Grossman, L P McLaurin
Journal: Circulation (1977)

The increased left ventricular end-diastolic pressure associated with myocardial ischemia was studied in 19 patients at cardiac catheterization. Single plane left ventriculograms were performed using high fedelity micromanometer tipped catheters before and immediately following rapid atrial pacing. Left ventricular diastolic properties were evaluated by constructing diastolic pressure-volume curves from the simultaneous pressure and volume data. In seven control patients, there was no significant change in left ventricular hemodynamics or the diastolic pressure-volume curve after atrial pacing. Twelve patients with significant coronary artery disease developed angina during pacing and had an increased left ventricular end-diastolic pressure (18 +/- 2 mm Hg, control, vs 30 +/- 2 mm Hg, angina, P less than .01) in the immediate post-pacing period. In these patients, the post-pacing ejection fraction was modestly decreased (0.63 +/- 0.03, control, vs 0.57 +/- 0.03, angina P less than 0.01), and left ventricular volumes at end systole (59 +/- 8 cc, control, vs 74 +/- 9 cc, angina, P less than 0.0125) were increased. The post-pacing diastolic pressure-volume curves in all 12 patients were shifted upward as compared with control so that for any given diastolic volume, pressure was higher during angina. The data indicate that the increased left ventricular diastolic pressure during myocardial ischemia is the result of both impaired left ventricular systolic performance and altered left ventricular diastolic properties.
Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors
Authors: Pearlie K. Epling-Burnette, Fanqi Bai, Jeffrey S. Painter, Dana E. Rollison, Helmut R. Salih, Matthias Krusch, JianXiang Zou, Edna Ku, Bin Zhong, David Boulware, Lynn Moscinski, Sheng Wei, Julie Y. Djeu, Alan F. List
Journal: Blood (2007)
810-5 Use of either metformin or thiazolidinedione is associated with improved survival among patients with type 2 diabetes from a registry of 16,203 diabetic patients
Authors: Farangis Lavasani, Joseph B Muhlestein, Dalton Einhorn, Robert R Pearson, Heath U Jones, Benjamin D Horne, Tami L Bair, Heidi Thomas, Dale G Renlund, Donald L Lappe, Jeffrey L Anderson
Journal: Journal of the American College of Cardiology (2004)
Gastric Myoelectrical Activity in Patients With Diabetes: Role of glucose control and autonomic nerve function
Authors: Takahiko Kawagishi, Yoshiki Nishizawa, Masanori Emoto, Kiyoshi Maekawa, Yasuhisa Okuno, Hiromichi Taniwaki, Masaaki Inaba, Eiji Ishimura, Hirotoshi Morii
Journal: Diabetes Care (1997)

OBJECTIVE Gastric myoelectrical activity was studied in diabetic patients using electrogastrography (EGG) to elucidate the relationship between glucose control, diabetic autonomic neuropathy (AN), and gastrointestinal motility. RESEARCH DESIGN AND METHODS Cutaneous EGG was recorded during 1 h of fasting and 1 h after the ingestion of a standard meal in 57 diabetic patients and 10 healthy subjects. EGG was measured in 12 diabetic patients after glycemic control for 4 weeks. Diabetic patients were also studied with respect to the presence of gastrointestinal symptoms and AN. RESULTS The percentage of dominant electrical frequency (DF) in normal range (the percentage ratio between the power at 2.4–3.6 cycles/min [cpm] and at 1–10 cpm) was significantly lower in patients with AN than in either the control subjects or the patients without AN (P &amp;lt; 0.01). The dominant frequency instability coefficient (DFIC) was significantly higher in patients with and without AN than in the control subjects (P &amp;lt; 0.01). The postprandial-to-fasting power ratio (PR) was the lowest in patients with AN (P &amp;lt; 0.01). Multiple regression analysis revealed that HbA1c levels were independently associated with the DFIC (R2 = 0.099, P = 0.0170) and that AN and HbA1c levels were independently associated with the PR (R2 = 0.378, P &amp;lt; 0.0001) in diabetic patients. The percentage of normal DF increased and the DFIC decreased significantly after glycemic control in 12 diabetic patients (P = 0.0409; P = 0.0096, respectively). CONCLUSIONS There appears to be an association between improvement in gastric myoelectrical activity and autonomic nerve function. Abnormalities of gastric myoelectrical activity may be partly ameliorated via the improvement of autonomic nerve function, which accompanies glycemic control.
Drugs for Pregnant and Lactating Women
Authors: David M. Stamilio
Journal: Annals of Internal Medicine (2004)

Medical Writings: Book Notes2 March 2004Drugs for Pregnant and Lactating WomenDavid M. Stamilio, MD, MSCEDavid M. Stamilio, MD, MSCEFrom University of Pennsylvania Health System, Philadelphia, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-5-200403020-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Weiner CP, Buhimschi C, eds. 1101 pages. Philadelphia: Churchill Livingstone; 2004. $89.00. ISBN 0443066078. Order phone 800-545-2522.Field of medicine: Obstetrics and pediatrics.Format: Hardcover book and PDA software (CD-ROM).Audience: Clinicians who provide obstetric care and breastfeeding recommendations.Purpose: “To provide a user-friendly, pregnancy–lactation-focused reference” that discusses “how virtually all prescription drugs and many herbal supplements affect pregnancy and lactation.”Content: The book reviews the pregnancy and lactation effects of over 725 generic and 2200 brand-name drugs and herbal supplements. Many over-the-counter medications are also reviewed. Each drug is appraised in a 1- to 2-page description divided into 9 ... Author, Article, and Disclosure InformationAffiliations: From University of Pennsylvania Health System, Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDoes the Anticholinergic Drug Biperiden Affect Early Neural Tube Development in Chick Embryos? 2 March 2004Volume 140, Issue 5Page: 408KeywordsBreast feedingDrug administrationDrug safetyDrugsFood and Drug AdministrationHealth economicsLactationPregnancySafetySoftware tools ePublished: 2 March 2004 Issue Published: 2 March 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Guns and Homicide in the Home
Authors: Arthur L. Kellermann
Journal: New England Journal of Medicine (1998)

To the Editor: An independent review of the data from a case–control study of gun ownership as a risk factor for homicide in the home, reported by my colleagues and me (Oct. 7, 1993, issue),1 has identified an inaccuracy in our response to the letters to the editor about the study (Feb. 3, 1994, issue).2 In the fourth paragraph of our response, we reported, “Ninety-three percent of the homicides involving firearms occurred in homes where a gun was kept, according to the proxy respondents.” What we should have said was that 93 percent of proxy respondents for victims of homicide . . .
Autologous bone-marrow transplants compared with chemotherapy for children with acute lymphoblastic leukaemia in a second remission: a matched-pair analysis
Authors: A Borgmann, H Schmid, R Hartmann, E Baumgarten, G Henze, K Hermann, T Klingebiel, W Ebell, F Zintl, H Gadner
Journal: The Lancet (1995)
Plasma and urine enrichments following infusion of l-[1-13C]phenylalanine and l-[ring-2H5]phenylalanine in humans: Evidence for an isotope effect in renal tubular reabsorption
Authors: Gordon A. Zello, Lajos Marai, Amy S.F. Tung, Ronald O. Ball, Paul B. Pencharz
Journal: Metabolism (1994)
Energetic state is a strong regulator of sarcoplasmic reticulum Ca2+ loss in cardiac muscle: different efficiencies of different energy sources
Authors: M. Kuum, A. Kaasik, F. Joubert, R. Ventura-Clapier, V. Veksler
Journal: Cardiovascular Research (2009)

Increased diastolic sarcoplasmic reticulum (SR) Ca2+ loss could depress contractility in heart failure. Since the failing myocardium has impaired energetics, we investigated whether Ca2+ loss is linked to changes in energetic pathways. Leakage from SR in mouse permeabilized preparations was assessed using exogenous ATP, ATP + phosphocreatine (activation of bound creatine kinase, CK), ATP + mitochondrial substrates (mitochondrial activation), or with all of these together (optimal energetic conditions) in Ca2+-free solution. In ventricular fibres caffeine-induced tension transients under optimal energetic conditions were used to estimate SR [Ca2+]. In cardiomyocytes, intra-SR Ca2+ was monitored by use of the fluorescent marker Mag-fluo 4. In fibres, SR Ca2+ content after 5 min incubation strongly depended on energy supply (100%—optimal energetic conditions; 27 ± 5%—exogenous ATP only, 52 ± 5%—endogenous CK activation; 88 ± 8%—mitochondrial activation, P < 0.01 vs. CK system). The significant loss with only exogenous ATP was not inhibited by the ryanodine receptor blockers tetracaine or ruthenium red. However, the SR Ca2+-ATPase (SERCA) inhibitors cyclopiazonic acid or 2,5-di(tert-butyl)-1,4-benzohydroquinone significantly decreased Ca2+ loss. At 100 nM external [Ca2+], the SR Ca2+ loss was also energy dependent and was not significantly inhibited by tetracaine. In cardiomyocytes, the decline in SR [Ca2+] at zero external [Ca2+] was almost two times slower under optimal energetic conditions than in the presence of exogenous ATP only. At low extra-reticular [Ca2+], the main leak pathway is an energy-sensitive backward Ca2+ pump, and direct mitochondrial-SERCA ATP channelling is more effective in leak prevention than local ATP generation by bound CK.
Thiazolidinediones increased risk for heart failure, myocardial infarction, and death in older patients with type 2 diabetes
Authors: Raj Padwal
Journal: Annals of Internal Medicine (2008)

ACP Journal Club17 June 2008Thiazolidinediones increased risk for heart failure, myocardial infarction, and death in older patients with type 2 diabetesRaj Padwal, MDRaj Padwal, MDUniversity of Alberta, Edmonton, Alberta, Canada (R.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-12-200806170-02013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationLipscombe LL, Gomes T, Lévesque LE, et al. Thiazolidinediones and cardiovascular outcomes in older patients with diabetes. JAMA. 2007;298:2634-43. https://pubmed.ncbi.nlm.nih.gov/18073359Clinical Impact RatingsGIM/FP/GP: Cardiology: Endocrinology: Geriatrics: References1 Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007;356:2457-71. [PMID: 17517853] Google Scholar2 Krall RL. Cardiovascular safety of rosiglitazone [letter]. Lancet. 2007;369:1995-6. [PMID: 17574083] Google Scholar3 Lago RM, Singh PP, Nesto RW. Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials. Lancet. 2007;370:1129-36. [PMID: 17905165] Google Scholar4 Cleland JG, Atkin SL. Thiazolidinediones, deadly sins, surrogates, and elephants [comment]. Lancet. 2007;370:1103-4. [PMID: 17905146] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Alberta, Edmonton, Alberta, Canada (R.P.)This article was published at Annals.org on 3 June 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 June 2008Volume 148, Issue 12Page: JC4-13KeywordsCohort studiesDrugsHeart failureHospitalizationsHypoglycemicsInsulinMyocardial infarctionRisk managementType 2 diabetes ePublished: 17 June 2008 Issue Published: 17 June 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Circulating Colony Stimulating Factor-1 and Breast Cancer Risk
Authors: Rulla M. Tamimi, Joan S. Brugge, Matthew L. Freedman, Alexander Miron, J. Dirk Iglehart, Graham A. Colditz, Susan E. Hankinson
Journal: Cancer Research (2008)

Abstract Colony stimulating factor-1 (CSF1) and its receptor (CSF1-R) are important in mammary gland development and have been implicated in breast carcinogenesis. In a nested case-control study in the Nurses' Heath Study of 726 breast cancer cases diagnosed between June 1, 1992, and June 1, 1998, and 734 matched controls, we prospectively evaluated whether circulating levels of CSF1 (assessed in 1989–1990) are associated with breast cancer risk. The association varied by menopausal status (Pheterogeneity = 0.009). CSF1 levels in the highest quartile (versus lowest) were associated with an 85% reduced risk of premenopausal breast cancer [relative risk (RR), 0.15; 95% confidence interval (95% CI), 0.03–0.85; Ptrend = 0.02]. In contrast, CSF1 levels in the highest quartile conferred a 33% increased risk of postmenopausal breast cancer (RR, 1.33; 95% CI, 0.96–1.86; Ptrend = 0.11), with greatest risk for invasive (RR, 1.45; 95% CI, 1.02–2.07; Ptrend = 0.06) and ER+/PR+ tumors (RR, 1.72; 95% CI, 1.11–2.66; Ptrend = 0.04). Thus, the association of circulating CSF1 levels and breast cancer varies by menopausal status. [Cancer Res 2008;68(1):18–21]
Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts.
Authors: S R Goldring, M L Stephenson, E Downie, S M Krane, J H Korn
Journal: Journal of Clinical Investigation (1990)

Fibroblasts cultured from normal human dermis are heterogeneous with respect to growth kinetics, synthetic function, and morphologic features. There are many examples of clonal heterogeneity in apparently homogeneous connective tissue cell populations, and it has been suggested that selection of cell populations with particular phenotypic features is the basis for the development of pathologic connective tissue changes in inflammatory disorders. In these studies we report characterization of the pattern of matrix biosynthesis and responses to hormones in cells cloned from normal human dermis. The results indicate that cloned dermal fibroblasts are heterogeneous with respect to synthesis of collagens as well as their responses to prostaglandin E2 and parathyroid hormone. Selective expansion of clonal populations with unique patterns of matrix synthesis and cell surface receptors could provide the basis for abnormal connective tissue remodeling in certain pathologic states.
Neutrophil Collagenase, Gelatinase, and Myeloperoxidase in Tears of Patients with Stevens-Johnson Syndrome and Ocular Cicatricial Pemphigoid
Authors: Samer N. Arafat, Ana M. Suelves, Sandra Spurr-Michaud, James Chodosh, C. Stephen Foster, Claes H. Dohlman, Ilene K. Gipson
Journal: Ophthalmology (2013)
A Clinical Evaluation of the Urethral Catheter
Authors: Robert Lich
Journal: JAMA (1962)

The hazards of urethral catheterization are not in the catheter per se but in the indications observed, the technique followed, and the skill of the operator. The authors did not encounter a single instance of infection after catheterization of a functionally normal urinary tract. Even mild degrees of urodysfunction, defined as abnormality of urine transport, were associated with a risk of infection. In recognizing urodysfunction, the static picture afforded by cystoscopy needs to be supplemented by the functional data supplied by such methods as the voiding vesicourethrography used by the authors. The urethral catheter is essential in both diagnosis and treatment. In the opinion of the authors, the catheter and chronic pyelonephritis are not related unless there coexists some degree of urodysfunction.
Gemcitabine and CHK1 Inhibition Potentiate EGFR-Directed Radioimmunotherapy against Pancreatic Ductal Adenocarcinoma
Authors: Fares Al-Ejeh, Marina Pajic, Wei Shi, Murugan Kalimutho, Mariska Miranda, Adnan M. Nagrial, Angela Chou, Andrew V. Biankin, Sean M. Grimmond, Michael P. Brown, Kum Kum Khanna
Journal: Clinical Cancer Research (2014)

To develop effective combination therapy against pancreatic ductal adenocarcinoma (PDAC) with a combination of chemotherapy, CHK1 inhibition, and EGFR-targeted radioimmunotherapy.
Abstract 190: Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice by suppressing aldo-keto reductase family 1B10 (AKR1B10).
Authors: Jie Liao, Yeon Tae Chung, Haonan Li, Wanying Zhang, Guang-Yu Yang
Journal: Cancer Research (2013)

Abstract Sulindac inhibits carcinogenesis via the mechanism that appears beyond cyclooxygenase inhibition. Recently sulindac has been identified as competitive inhibitors of aldo-keto reductase family 1B10 (AKR1B10). AKR1B10 is involved in the process of carbonyls, farnesyl and geranylgeranyl as well as retinal metabolisms, and these metabolic activities are important to carcinogenesis. However, there is no evidence on if inhibition of pancreatic carcinogenesis by sulindac is via inhibition of AKR1B10 and protein prenylation (i.e., Kras protein). To determine the effect of sulindac on pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice, five-week-old mice were fed with either AIN-93M diet or AIN-93M diet contained 200ppm sulindac (n=20 mice/group). Kaplan-Meier survival analysis with Log-Rank test was performed to analyze the effect of sulindac on animal survival from the development of pancreatic carcinoma. The results showed that average animal survival in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice was 143.7 ± 8.8 days; and with the sulindac 200ppm treatment, animal survival significantly increased to 168.0 ± 8.8 days (p&amp;lt;0.005). Extensively histopathological analyses revealed that 90% of mice developed malignant pancreatic carcinomas, of which 10% invasive pancreatic adenocarcinoma had metastasis to liver and lymph nodes. With 200ppm sulindac treatment, incidence of pancreatic cancer and its metastasis were significantly reduced to 56% and 0%, respectively (P&amp;lt;0.01). Immunchemical analysis showed that sulindac treatment significantly decreased Ki-67-labeled cell proliferation, increased caspase-3-labeled cell apoptosis, and suppressed phosphorylated ERK1/2. In vitro mouse pancreatic carcinoma cells derived from the LSL-KrasG12D/+-LSL-Trp53R172/+-Pdx-1-Cre mice were further treated with sulindac and revealed that sulindac inhibited AKR1B10 enzyme activity, suppressed Kras and HDJ2 protein prenylation, and further inhibited phosphylation of C-raf, ERK1/2 and MEK1/2. Similar to sulindac treatment, siRNA-silencing AKR1B10 expression resulted in a significant reduction of Kras protein prenylation and its downstream signals. Our results demonstrate that sulindac inhibits pancreatic carcinogenesis, mainly via inhibition of kras protein prenylation and its activated signals by targeting AKR1B10. (supported NCI R01 CA164041) Citation Format: Jie Liao, Yeon Tae Chung, Haonan Li, Wanying Zhang, Guang-Yu Yang. Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice by suppressing aldo-keto reductase family 1B10 (AKR1B10). [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 190. doi:10.1158/1538-7445.AM2013-190
Methotrexate ameliorates T cell dependent autoimmune arthritis and encephalomyelitis but not antibody induced or fibroblast induced arthritis
Authors: Franziska Lange, Estelle Bajtner, Carola Rintisch, Kutty Selva Nandakumar, Ulrich Sack, Rikard Holmdahl
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objective:</b> To investigate the mode of action of methotrexate (MTX) in different types of models for rheumatoid arthritis (RA) and multiple sclerosis (MS). <b>Methods:</b> Models for RA and MS were selected known to have different pathogenesis—that is, fibroblast induced arthritis in SCID mice, collagen induced arthritis (CIA), anticollagen II antibody induced arthritis (CAIA), and experimental autoimmune encephalomyelitis (EAE) in (Balb/c×B10.Q)F1 and B10.Q mice, and Pristane induced arthritis in DA rats (PIA). The MTX treatment was started 1 day after the onset of disease and continued for 14 days to compare effects on the different models. <b>Results:</b> All models known to be critically dependent on T cell activation (CIA, PIA, and EAE) were effectively down regulated by titrated doses of MTX. In contrast, no effects were seen on fibroblast induced arthritis or CAIA. No effects were seen on the levels of anticollagen II antibodies in the CIA experiment. <b>Conclusion:</b> The data show that MTX has strong ameliorative effect on both classical models of RA, like CIA and PIA, but also on a model for MS, EAE. It also suggests that MTX operates only in diseases which are preceded by, and dependent on, T cell activation. A comparison of CAIA and CIA suggested that MTX operates independently of arthritogenic antibodies. These results demonstrate that different animal models reflect the complexity of the corresponding human diseases and suggest that several models should be used for effective screening of new therapeutic agents.
The Burden of Functional Recovery from ARDS
Authors: Jesse B. Hall, John P. Kress
Journal: New England Journal of Medicine (2011)

The acute respiratory distress syndrome (ARDS) is commonly a cause for admission to the intensive care unit (ICU) and for mechanical ventilation. Within the past decade, research has shown not only that the need for acute supportive care is extensive and protracted, but also that the arc of recovery can be long, and the burden for survivors of ARDS is actually psychological and neuromuscular dysfunction.1,2 Ironically, the respiratory system seems to respond with a relatively rapid and complete recovery. A groundbreaking paper by Herridge and colleagues in the Journal nearly 8 years ago described the physical and psychological disabilities . . .
Head Injury as Risk Factor for Psychiatric Disorders: A Nationwide Register-Based Follow-Up Study of 113,906 Persons With Head Injury
Authors: Sonja Orlovska, Michael Skaarup Pedersen, Michael Eriksen Benros, Preben Bo Mortensen, Esben Agerbo, Merete Nordentoft
Journal: American Journal of Psychiatry (2013)

A head injury, especially a severe head injury or one occurring between the ages of 11 and 15, increased the risk for subsequent schizophrenia by 65%, the risk of depression by 59%, the risk of bipolar disorder by 28%, and the risk of organic mental disorders by more than 400% in this largest-to-date analysis of data from over 100,000 individuals.
Neuronatin Expression and Its Clinicopathological Significance in Pulmonary Non-small Cell Carcinoma
Authors: Teruhito Uchihara, Chigusa Okubo, Ryota Tanaka, Yuko Minami, Yukinori Inadome, Tatsuo Iijima, Yukio Morishita, Jiro Fujita, Masayuki Noguchi
Journal: Journal of Thoracic Oncology (2007)
Response to Letters Regarding Article, “Supervised Exercise Versus Primary Stenting for Claudication Resulting From Aortoiliac Peripheral Artery Disease: Six-Month Outcomes From the Claudication: Exercise Versus Endoluminal Revascularization (CLEVER) Study”
Authors: Timothy P. Murphy, Joselyn Cerezo, Donald E. Cutlip, Matthew R. Reynolds, Judith G. Regensteiner, Emile R. Mohler, David J. Cohen, Joseph M. Massaro, Beth A. Lewis, Niki C. Oldenburg, Michael W. Steffes, Alan T. Hirsch, Claudia C. Thum, Suzanne Goldberg, Michael R. Jaff, Anthony J. Comerota, Jonathan Ehrman, Diane Treat-Jacobson, Ulf Bronas, M. Eileen Walsh, Dalynn T. Badenhop, Tracie Collins
Journal: Circulation (2012)