tbuckley/cabot-search huggingface dataset:
Acute hemodynamic effects of nifedipine in patients with ischemic heart disease.
Authors: P A Majid, J De Jong
Journal: Circulation (1982)

We studied the acute hemodynamic effects of nifedipine in 20 patients with angiographically proved coronary artery disease. Eight patients were studied during exercise-induced pain. There was an expected abnormal increase in pulmonary wedge pressure (28 +/- 8 mm Hg, mean +/- SD) accompanying chest pain (onset 179 seconds, duration 334 seconds) and ST-segment depression (2.2 +/- 0.9 mm) on the ECG. Pacing stress was used in six patients and increased left ventricular (LV) end-diastolic pressure (from 16 +/- 6 to 26 +/- 6 mm Hg), volumes (end-diastolic 63 +/- 20 to 81 +/- 22 ml/m2, end-systolic 26 +/- 15 to 47 +/- 16 ml/m2) and impaired ejection fraction (0.60 +/- 0.15 to 0.44 +/- 0.11) compared with control values. In both groups, nifedipine, 20 mg sublingually, significantly shortened duration of pain, reduced ST depression on the ECG (p less than 0.001) and reversed all hemodynamic abnormalities. In another group of six patients with recent (less than 4 months) acute myocardial infarction and moderately severe LV dysfunction at rest, nifedipine reduced LV end-diastolic pressure from 21 +/- 6 to 12 +/- 5 mm Hg and volumes (end-diastolic from 109 +/- 35 to 95 +/- 32 ml/m2, end-systolic from 41 +/- 15 to 31 +/- 7 ml/m2), while the ejection fraction improved significantly, from 0.43 +/- 0.08 to 0.58 +/- 0.11. Thus, the antianginal effect of nifedipine is associated with improved systolic emptying and reduced diastolic filling of the heart. Nifedipine appears to have no discernible adverse effects in patients with depressed LV function.
Neonatal serum bilirubin estimation.
Authors: T. Hargreaves
Journal: BMJ (1969)

logist, has equally carefully been removed by the printers.While this state of affairs pertains the greatest economy in illustration is required to allow editors to present a few really worth-while pictures in colour.If in the course of such an economy drive a few unwanted papers and magazines were sup- pressed altogether, we might comfort our- selves with the thought that the illustrations in the remaining journals might perhaps be worth looking at.-I am, etc., E. ELKAN.Pinner, Middx.SIR,-I have long ceased to wonder at the often seemingly uninformed and unintelligent actions of Government departments (3 May, p. 266).Presumably ithey are the outcome of meetings in committee where informed and intelligent men have found themselves dead- locked on important issues and turn with relief to a marginal issue which can be agreed and pursued unitedly.So we have such weighty trivia as Health Trends, Proplist, and so on.On the other hand, since the proper treatment of narcotic addicts or of psychogeriatric patients, for example, is far more important, opinion is divided on which need comes first and money can be made available for neither.-Iam, etc.,
"SURGERY OF THE SPINE AND EXTREMITIES"
Authors: R. Hunstall Taylor
Journal: JAMA (1924)

<h3>To the Editor:</h3> — InThe Journal, March 22, page 995, appears under Book Notices the review of my last book, "Surgery of the Spine and Extremities." The critic takes exception to my use of the adjective "tubercular." I wish to note that I use the adjectives "tuberculous" and "tubercular" interchangeably, and will give my authorities for so doing. He says, referring to the discussion of tuberculosis of the spine, "Here, as elsewhere, the author uses the adjective 'tubercular' instead of the correct word, `tuberculous,' which is surprising. 'Tubercular' means `knobby,' and may be applied to a potato, but not to a tuberculous spine." These adjectives are used synonymously, and I would refer to Worcester's Unabridged Dictionary, page 1551; Webster's Unabridged Dictionary, page 1181; Century Dictionary, Volume VIII, page 6519, and in the last named one will find "tubercular" as the invariable prefix to tuberculosis of the various parts of
Early Syphilis With Liver Involvement
Authors: David S. Keisler
Journal: JAMA (1982)

SECONDARY syphilis of the liver is a treatable disease that may have unusual manifestations. Often, the disease is difficult to diagnose, requiring expensive testing and delaying initiation of therapy.<sup>1-4</sup>The finding of a spirochete on liver biopsy is diagnostic, but rare; only two authors have published photographic documentation of spirochetes in the liver.<sup>5,6</sup>Other less-invasive test results may also suggest secondary involvement of the liver. We describe a patient with typical serological and laboratory findings who was treated successfully for secondary syphilis of the liver after a biopsy specimen disclosed a rare spirochete in the portal tracts. <h3>Report of a Case</h3> A 27-year-old homosexual man was admitted to the hospital for evaluation of epigastric pain and elevated serum alkaline phosphatase levels. Ten days earlier, he had had dull, intermittent epigastric pain that was exacerbated by eating and bending over. He denied nausea, vomiting, jaundice, or fever. He had
Dance me loose
Authors: Z. Danilevicius
Journal: JAMA (1978)

Do you remember that old song "Dance Me Loose?" The girl in the song complained about being held too tight. Well, this is not the only danger involved in dancing, especially stage dancing. Washington<sup>1</sup>reminds us that when "we are seated in a large theater about to witness a performance by one of America's fine dance companies," and "the house lights dim and the melancholy strains of the overture from Tchaikovsky's<i>Swan Lake</i>fill the great hall," the dancers are often exposed to a whole gamut of orthopedic injuries. The fine structure and functional ability of the human body, which allow such beautiful and seemingly effortless movement as in ballet, are to be admired. But what sort of orthopedic problems do these dancers encounter in their work? Is the pattern of injuries of the various areas of the body in dancers the same as in athletes? How are these problems
RECIPROCAL EFFECTS OF CONCOMITANT INFECTIONS
Authors: Louise Pearce
Journal: The Journal of Experimental Medicine (1928)

Experiments are reported in which was studied the effect of a concomitant infection, vaccinia, upon the syphilitic reaction of rabbits. Vaccine virus was inoculated intracutaneously on the side of the body at the time of intratesticular inoculation with Treponema pallidum. The results showed clearly that the vaccination caused a profound disturbance in the syphilitic reaction, the ensuing syphilis being extremely severe. From an analysis of various features of the reaction, it appeared that the factor of host resistance was primarily concerned in the effects observed.
β2-microglobulin: A new form of amyloid protein associated with chronic hemodialysis
Authors: Fumitake Gejyo, Shoji Odani, Toshiyuki Yamada, Noriyuki Honma, Hidehiko Saito, Yasushi Suzuki, Yoichi Nakagawa, Hiroyuki Kobayashi, Yuichiro Maruyama, Yoshihei Hirasawa, Masashi Suzuki, Masaaki Arakawa
Journal: Kidney International (1986)
SOME COMMON ERRORS IN THE TREATMENT OF PULMONARY TUBERCULOSIS.
Authors: NORMAN BRIDGE
Journal: JAMA (1905)

Few subjects in all medicine have received such thorough study in our time as tuberculosis. Current methods in the treatment of its pulmonary form average better than those of old. Results show this fact. The tuberculosis mortality has been reduced in less than three decades by probably 29 per cent. of the former figure, or from 14.25 to 10 per cent. of all deaths. These results are not accidental, but are clearly due more to the better management of the pulmonary form than to any other influence. The disease is still one of the most appalling of the list. It attacks probably half of all the people at some time in their lives, and it destroys a tenth of them finally, and it deserves the best thought of all physicians. If the best methods of treatment now are better than those of the last century, we should logically
Skin graft rejection by beta 2-microglobulin-deficient mice.
Authors: M Zijlstra, H Auchincloss, J M Loring, C M Chase, P S Russell, R Jaenisch
Journal: The Journal of Experimental Medicine (1992)

Mice homozygous for a beta 2-microglobulin (beta 2-m) gene disruption lack beta 2-m protein and are deficient for functional major histocompatibility complex class I (MHC-I) molecules. The mutant mice have normal numbers of CD4+8- T helper cells, but lack MHC-I-directed CD4-8+ cytotoxic T lymphocytes (CTLs). In this study we used the beta 2-m mutant mice to study the importance of MHC-I-directed immunity in skin graft rejection. Our results indicate that MHC-I-directed CD8+ CTLs are not essential in the rejection of allografts with whole MHC or multiple minor H differences. However, the absence of MHC-I-guided immunity profoundly reduces the ability of mutant mice to reject H-Y disparate grafts. In addition, we show that natural killer cells which vigorously reject MHC-I-deficient bone marrow grafts, are not effective in the destruction of MHC-I-deficient skin grafts.
Local Low-Dose Thrombolytic Therapy of Peripheral Arterial Occlusions
Authors: Hans Hess, Heinrich Ingrisch, Andreas Mietaschk, Hans Rath
Journal: New England Journal of Medicine (1982)

Local thrombolytic therapy has previously been used in selected patients to treat obstructive arterial lesions.1 2 3 The methods of these earlier investigators involved insertion of a catheter into an occluding arterial lesion and continuous "blind" infusion of streptokinase in doses of 1000 to 100,000 units per hour (total dose, 100,000 to 1.6 million units) for periods of less than one day to as long as two weeks. In an effort to shorten the procedure and reduce the amount of streptokinase administered, thereby decreasing the risk of systemic bleeding, we developed a system for providing local low-dose thrombolytic therapy by direct infiltration . . .
Psychological impact of adjuvant chemotherapy in the first two years after mastectomy.
Authors: A V Hughson, A F Cooper, C S McArdle, D C Smith
Journal: BMJ (1986)

Psychological symptoms were assessed over two years in a randomised trial of three forms of treatment given to women after mastectomy for stage II breast cancer. The treatments were: three weeks9 radiotherapy; one year9s adjuvant chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil; and radiotherapy followed by chemotherapy. Analysis of the results on an intention to treat basis showed no substantial differences in depression or anxiety among groups at one, three, or six months after the operation. At 13 months, however, patients who had been allocated chemotherapy had significantly more symptoms, especially depression, than control patients treated with radiotherapy alone. Conditioned reflex nausea and vomiting increased considerably during the second six months of chemotherapy and persisted for up to a year afterwards. The psychological morbidity of adjuvant chemotherapy could be substantially reduced if courses of treatment were restricted to about six months.
Surfactant-free anionic PLA nanoparticles coated with HIV-1 p24 protein induced enhanced cellular and humoral immune responses in various animal models
Authors: Yasemin Ataman-Önal, Séverine Munier, Arnaud Ganée, Céline Terrat, Pierre-Yves Durand, Nicole Battail, Frédéric Martinon, Roger Le Grand, Marie-Hélène Charles, Thierry Delair, Bernard Verrier
Journal: Journal of Controlled Release (2006)
Flow Limitation in Infants Assessed by Negative Expiratory Pressure
Authors: MARCUS H. JONES, STEPHANIE D. DAVIS, JEFFREY A. KISLING, JOHN M. HOWARD, ROBERT CASTILE, ROBERT S. TEPPER
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Forced expiratory flows by the rapid compression technique are often used to assess airway function in infants; however, it remains unclear as to whether flow limitation (FL) is achieved. Studies in adults have used negative expiratory pressure (NEP) at the airway opening as a noninvasive technique to assess whether FL is achieved. An increase in flow with NEP indicates that FL has not been achieved, whereas no increase in flow with NEP indicates FL has been achieved. In the adult studies, the change in flow was assessed by visual inspection of the flow–volume curve. We evaluated whether NEP could be used to assess FL during forced expiration in infants. In addition, we quantified the change in flow secondary to NEP. We applied − 5 cm H2O NEP to four infants during forced expiratory maneuvers. The step increase in flow with NEP was always less than 5% at high jacket compression pressures and consistent with FL. For one subject, FL was also confirmed from isovolume pressure flow–curves measured with an esophageal catheter. We conclude that NEP can be used in infants to assess FL during forced expiratory maneuvers by the rapid compression technique. Jones MH, Davis SD, Kisling JA, Howard JM, Castile R, Tepper RS. Flow limitation in infants assessed by negative expiratory pressure.
P184 Can we predict asthma exacerbations in working-age adults?
Authors: S. J. MacNeill, A. B. Jones, C. J. P. Smith, R. Hubbard, P. Cullinan
Journal: Thorax (2010)

<h3>Introduction</h3> Little information exists on the prevalence and risk factors of asthma exacerbations in the general population. We used GP records to determine whether we can predict exacerbations in adults from their medical history. <h3>Methods</h3> Using the Health Improvement Network database, weidentified all patients aged 16–40 years with “current asthma” (≥1 asthma prescription between 01/07/98 and 01/07/00). Three types of asthma exacerbations were studied: “hospital” defined as events resulting in attendance at A&amp;E or admission; “GP” defined as events occurring during out-of-hours consultations; and “prednisolone” defined as non-repeat prescriptions of oral prednisolone for asthma. <h3>Results</h3> 73 462 patients were identified. They were on average 28 years old and 56% were female. 36,762 (50%) were registered for at least 5 years pre-qualification and 1 year post. Of these, 0.3% had at least one hospital exacerbation in the first year post, 2.4% had at least one GP exacerbation and 8.3% had at least one prednisolone exacerbation. Women and those prescribed a reliever and preventor at qualification were more likely to have exacerbations (see Abstract P184 Table 1). The prevalence of exacerbations was associated with an increasing number and increasingly recent history of exacerbations pre-qualification. <h3>Discussion</h3> These results show that while few have hospital exacerbations, GP and prednisolone exacerbations are comparatively common. For all types, a previous and recent history of exacerbations increases the risk of future exacerbations.
Cardiorespiratory Fitness Is Strongly Related to the Metabolic Syndrome in Adolescents
Authors: Gabriel Q. Shaibi, Martha L. Cruz, Michael I. Goran
Journal: Diabetes Care (2008)

The recent report by Janseen and Cramp (1), describing the independent associations between cardiorespiratory fitness (CRF) and the metabolic syndrome in adolescents participating in the National Health and Nutrition Examination Survey 1999–2002, addresses a critical issue related to fitness and chronic disease risk in youth. However, the authors’ findings and interpretation should be received with caution. First, the authors suggest that CRF is an objective measure of physical …
Detection of Postcardiotomy Bacterial Pericarditis with Gallium-67 Citrate
Authors: LIONEL S. ZUCKIER, HEIDI S. WEISSMANN, MARK J. GOLDMAN, RICHARD BRODMAN, STEPHAN L. KAMHOLZ, LEONARD M. FREEMAN
Journal: Clinical Nuclear Medicine (1986)

A 46-year-old man who had undergone apical cardiac aneurysmectomy with a ventriculotomy graft and implanted automatic cardioverter-defibrillator electrodes, presented with fever, left-sided pleuritic chest pain, and a draining sinus. A Ga-67 scan was performed to aid in determining whether the infection was limited to the chest wall or if it had penetrated deeper to the cardiac structures. Uptake of gallium within the cardiac region, in association with minimal rib uptake of Tc-99m MDP, strongly supported the existence of infection within the pericardium. CT scan demonstrated a pericardial collection which under CT-guided aspiration proved to be purulent. Definitive surgical drainage was performed, and the patient was discharged 4 weeks postoperatively. Ga-67 imaging can provide an accurate and relatively rapid means of localizing infection in the postcardiotomy patient. A thorough bibliography of pericardial gallium uptake is provided.
Abstract 413: Genome-wide microarray expression and array-CGH analysis in neuroblastoma stem-like cells by use of the neurosphere-formation assay
Authors: Gabriel Gallo, Sheila Legarra, Xing Fan, Noemie Pata-Merci, Justine Guegan, Gisele Danglot, Alain Bernheim, Javier S. Castresana
Journal: Cancer Research (2012)

Abstract In this work, we aimed at analyzing genome-wide gene expression and DNA gains and losses in neuroblastoma cell lines and in neurospheres containing stem-like cells. SKNDZ and SIMA neuroblastoma cell lines were grown in DMEM cell culture medium, and in DMEM-F12 selective serum free medium (with EGF, bFGF and B27; to induce the neurosphere-forming phenotype). After RNA and genomic DNA extractions from the 4 cell lines (2 standard, 2 neurosphere-forming cell lines), expression microarrays and array-CGH analyses were performed (Aligent Technologies). Array-CGH did not show any significant differences between standard and neurosphere-forming cell lines, both in SKNDZ and in SIMA. Microarray expression analysis demonstrated a total of 425 upregulated and 170 downregulated genes in neurosphere-forming cell lines. The differentially expressed genes were classified using the PANTHER classification system (www.pantherdb.org). As a result, apoptosis, cell adhesion, cell communication, cell cycle, and immune system processes appeared upregulated and downregulated in neurospheres. Some of those genes participate in pathways related with cancer (Table 1). In conclusion, the stem-like phenotype does not seem to be linked to anatomic changes at the level of deletions/gains of DNA, but to changes in expression of genes, like those of the TGF-beta, Notch and Sonic Hedgehog pathways. Those pathways, specially TGF-beta, widely described as an important therapeutic target against cancer, should be further studied to determine their real implication in the neurosphere-formation process in neuroblastoma, and therefore, as candidate targets for the treatment of neuroblastoma stem-like cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 413. doi:1538-7445.AM2012-413
Cardiovascular reflex responses to apnoeic face immersion and mental stress in diabetic subjects
Authors: T. BENNETT, D. J. HOSKING, J. R. HAMPTON
Journal: Cardiovascular Research (1976)

The cardiovascular reflex responses to apnoea accompanied by immersion of the face in water and to mental stress, have been investigated in 21 diabetic subjects. Apnoeic face immersion caused bradycardia and forearm vasoconstriction (in seven subjects), bradycardia and forearm vasodilatation (three subjects), tachycardia and forearm vasoconstriction (three subjects), or tachycardia and forearm vasodilatation (eight subjects). Mental stress evoked a tachycardia and forearm vasodilatation in all subjects. The abnormalities in the responses to apnoeic face immersion are most readily accounted for by loss of vagal and/or vasoconstrictor function.
Frequent occurrence of anticardiolipin antibodies, Factor V Leiden mutation, and perturbed endothelial function in chronic myeloproliferative disorders
Authors: Morten Krogh Jensen, Peter de Nully Brown, Sixtus Thorsen, Hans Carl Hasselbalch
Journal: American Journal of Hematology (2002)

Abstract Chronic myeloproliferative disorders (MPD) are characterized by a high incidence of thrombohaemorrhagic complications, possibly related to platelet abnormalities and disturbances of the coagulation system. In an attempt to define abnormalities in coagulation and fibrinolysis, we investigated risk markers for venous thromboembolism, fibrinolytic, and haemostatic system activation markers and antiphospholipid antibodies in blood samples from 50 MPD patients and 30 controls. Compared with controls median levels of protein S free and protein C were significantly decreased in the patients (0.27 vs. 0.38 arbitrary units; P &lt; 0.001 and 0.86 vs. 0.99 arbitrary units; P &lt; 0.001, respectively), and activated partial thromboplastin time was significantly prolonged in patients (33 vs. 27 sec; P &lt; 0.001). No differences were observed in levels of antithrombin, thrombin–antithrombin complex, and fibrin D‐dimer. In patients the median value of thrombomodulin was significantly increased indicating perturbed endothelial function. Anticardiolipin antibodies of IgM subtype (median 38 U/mL, 33–99) were detected in 11 patients (22%) and only in one control (3%) ( P &lt; 0.021; patients vs. controls). Seven patients were heterozygous for the Factor V Leiden, one patient was heterozygous for the prothrombin G20210A mutation, and one patient was homozygous for the Factor V Leiden mutation. Among controls, two were heterozygous for the Factor V Leiden mutation. Comparing the allele frequency of the Factor V Leiden mutation in patients with MPD and the background population disclosed a significantly increased allele prevalence of the Factor V Leiden mutation in the patients (9% vs. 3.4%; P = 0.003). Alterations in the level of anticoagulant proteins, disturbances of endothelial cell function, and the presence of cardiolipin antibodies and Factor V Leiden mutation may increase the cumulative thrombotic risk in MPD besides the risk imposed by platelet activation. Am. J. Hematol. 69:185–191, 2002.© 2002 Wiley‐Liss, Inc.
Follow-up Studies of Acute Dissecting Aortic Aneurysms Managed with Antihypertensive Agents
Authors: P. D. HARRIS, J. R. MALM, J. T. BIGGER, F. O. BOWMAN
Journal: Circulation (1967)

Twelve patients with acute dissecting aneurysms have been treated with antihypertensive medications. These patients all presented with chest or back pain and had systolic blood pressures of greater than 160 mm Hg. They responded to drug-induced hypotension with loss of pain and stabilization of their general condition. Two patients died during the initial phase of therapy. In both these cases there was inadequate control of the blood pressure on an altered medication regime. Ten patients have now been followed for periods ranging from 1 month to 1 year. There has been no evidence either symptomatically or roentgenographically that these patients have had progression of their disease process.
Manual of Cancer Chemotherapy
Authors: Paul P. Carbone
Journal: JAMA (1983)

This pocket-sized spiral book is designed to provide the nononcologist with up-to-date information about cancer chemotherapy that allows participation in the care of patients with the expert oncologist. The book briefly presents the rationale of cancer chemotherapy, the important strategies of cancer treatment, and information on supportive care problems. The ideas are presented simply in outline form. The book is mainly written by Dr Roland Skeel with help from a few other recognized specialists, most clinical investigators with a great deal of practical knowledge as well as awareness of experimental therapy. The book is divided into four major parts dealing with the basic principles of chemotherapy, the classification of useful drugs, the treatment of specific cancers, and, finally, supportive care. Each is well written. In particular, the specific disease sections try to provide a brief description of staging as a method of deciding primary therapy. The book has an excellent