tbuckley/cabot-search huggingface dataset:
Cytoplasmic mutated nucleophosmin (NPM) defines the molecular status of a significant fraction of myeloid sarcomas
Authors: B Falini, D Lenze, R Hasserjian, S Coupland, D Jaehne, C Soupir, A Liso, M P Martelli, N Bolli, F Bacci, V Pettirossi, A Santucci, M F Martelli, S Pileri, H Stein
Journal: Leukemia (2007)
Evidence for a rebound coagulation phenomenon after cessation of a 4-hour infusion of a specific thrombin inhibitor in patients with unstable angina pectoris
Authors: Herman K. Gold, Frank W. Torres, Harry D. Garabedian, Wendy Werner, Ik-Kyung Jang, Agha Khan, J.Nathan Hagstrom, Tsunehiro Yasuda, Robert C. Leinbach, John B. Newell, Edwin G. Bovill, David C. Stump, Désiré Collen
Journal: Journal of the American College of Cardiology (1993)
Health-Service Systems in the United States and Other Countries — Critical Comparisons
Authors: Odin W. Anderson
Journal: New England Journal of Medicine (1963)

THE health services that have developed in Europe, Great Britain and the Commonwealth countries and the United States share basic similarities. They are products of advances in medical science that occurred from the late nineteenth century to World War I, when these countries were being transformed from agricultural to industrial economies. The discovery that bacteria caused a number of widespread diseases and the discovery and application of anesthesia in surgery provided the specific stimuli that led to the development of the modern hospital, the nursing profession and the hospital-based medical services. The medical profession was in existence in large numbers . . .
Sigmoidoscopy/proctoscopy service with open access to general practitioners.
Authors: I P Donald, J S FitzGerald Frazer, S P Wilkinson
Journal: BMJ (1985)

Many hospitals now offer barium enema examinations to general practitioners on an open access basis, so bypassing the traditional sequence of first carrying out a sigmoidoscopy. An open access sigmoidoscopy/proctoscopy service was therefore opened with requests for a barium enema being denied unless preceded by sigmoidoscopy. During the first three and a half years 1458 patients referred direct from their general practitioners were examined using a rigid sigmoidoscope. Patients were also examined with a proctoscope if thought appropriate. After the first year of the service a subsequent examination with a fibreoptic sigmoidoscope was also carried out if the presenting symptom was bleeding for which no cause could be found with the rigid instruments. A total of 516 abnormalities were found to account for symptoms in 506 patients giving a diagnostic rate of 35%. The most common lesion was piles (307 cases). Other relatively common disorders included inflammatory bowel disease (107 cases), benign tumours (44), and malignant tumours (38). Of 41 patients subsequently undergoing fibreoptic sigmoidoscopy a cause for the bleeding was found in 32, the most common being a malignant tumour (16). Most general practitioners in the district used the service and a questionnaire survey indicated that most found it very helpful. Requests from general practitioners for a barium enema fell substantially over the period.
Simplification and Improvement in Estimating Drug Dosage and Fluid and Dietary Allowances for Patients of Varying Sizes
Authors: Allan M. Butler, Robert H. Richie
Journal: New England Journal of Medicine (1960)

FOR over a century clinicians have known that infant dosages expressed per kilogram are excessive for adults and that adult dosages per kilogram are inadequate for infants.The BackgroundRecognizing this lack of proportionality of dosage to body weight, Hufeland,1 in 1830, proposed on the basis of clinical experience a scale of doses according to size, the doses expressed as percentage of adult dose being closely proportional to body-surface area. Moore,2 in 1909, wrote as follows:It is an almost universal custom at the present time, in describing scientific work of a pharmacological or therapeutic nature intended either to establish . . .
The addition of decision support into computerized physician order entry reduces red blood cell transfusion resource utilization in the intensive care unit
Authors: Evans R. Fernández Pérez, Jeffrey L. Winters, Ognjen Gajic
Journal: American Journal of Hematology (2007)

Abstract Computerized physician order entry (CPOE) has the potential for cost containment in critically ill patients through practice standardization and elimination of unnecessary interventions. Previous study demonstrated the beneficial short‐term effect of adding a decision support for red blood cell (RBC) transfusion into the hospital CPOE. We evaluated the effect of such intervention on RBC resource utilization during the two‐year study period. From the institutional APACHE III database we identified 2,200 patients with anemia, but no active bleeding on admission: 1,100 during a year before and 1,100 during a year after the intervention. The mean number of RBC transfusions per patient decreased from 1.5 ± 1.9 units to 1.3 ± 1.8 units after the intervention ( P = 0.045). RBC transfusion cost decreased from $616,442 to $556,226 after the intervention. Hospital length of stay and adjusted hospital mortality did not differ before and after protocol implementation. In conclusion, the implementation of an evidenced‐based decision support system through a CPOE can decrease RBC transfusion resource utilization in critically ill patients. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
Insulin Infusion Test of Gastric Acid Secretion
Authors: D. C. Carter, R. R. Dozois, J. R. Kirkpatrick
Journal: BMJ (1972)

In view of the disadvantages of the standard insulin test for completeness of vagotomy a continuous insulin infusion test has been developed. Twenty-six tests were carried out on 12 healthy male volunteers. A dose of 0·04 unit of soluble insulin/kg/hr was found to produce the highest acid secretion with the least severity of symptoms of hypoglycaemia. The pattern of response was a plateau of acid secretion and of hypoglycaemia, and repeated studies in six subjects showed that the results were reproducible. Evaluation of this test after vagotomy and comparison with the standard insulin test are now required.
Abstract 1519: Tyrosine kinase inhibitors are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance
Authors: Kamlesh Sodani, Ye-Hong Kuang, Tong Shen, Saurabh Vispute, Amit K. Tiwari, Yu Lei, Jeferson Lee, Xiang Chen, Charles R. Ashby, Zhe-Sheng Chen
Journal: Cancer Research (2010)

Abstract ATP binding cassette (ABC) transporters play a crucial role in the development of multidrug resistance (MDR) leading to failure of the cancer chemotherapy. Previously, we and others have reported that lapatinib, erlotinib (EGFR tyrosine kinase inhibitors/TKIs) and nilotinb, imatinib (BCR-Abl TKIs) reverse ABCB1- and ABCG2-mediated MDR. MRP7/ABCC10, a member of MRP family, shares a structural homology with other ABC transporters such as P-gp/ABCB1. MRP7 is involved in effluxing several anticancer drugs resulting in poor chemotherapeutic outcome. In an effort to reverse MRP7-mediated MDR, we discovered that EGFR TKIs lapatinib, erlotinib, and BCR-Abl TKIs imatinib, nilotinib enhances the sensitivity of MRP7-transfected HEK293 (HEK-MRP7-2) cells to the established MRP7 substrates, such as paclitaxel, docetaxel, vincristine and vinorelbine in concentration-dependent manner. However, there was no significant effect of these TKIs on the sensitivity of control HEK293-pcDNA3.1 cells. In addition, these TKIs increased the intracellular accumulation of [3H]paclitaxel, inhibiting MRP7-mediated [3H]paclitaxel efflux from HEK-MRP7-2 cells. Moreover, Western blot analysis showed no significant change in the MRP7 expression level in the MRP7 overexpressing cell line on treatment with aforementioned TKIs. We conclude that both EGFR TKIs (lapatinib, erlotinib) and BCR-Abl TKIs (imatinib, nilotinib) reverse MRP7-mediated MDR through inhibition of the drug efflux function of MRP7, suggesting that TKI based combinational chemotherapy may be useful in cancer clinical practice. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1519.
Impact of Angiographic Complete Revascularization After Drug-Eluting Stent Implantation or Coronary Artery Bypass Graft Surgery for Multivessel Coronary Artery Disease
Authors: Young-Hak Kim, Duk-Woo Park, Jong-Young Lee, Won-Jang Kim, Sung-Cheol Yun, Jung-Min Ahn, Hae Geun Song, Jun-Hyok Oh, Jong Seon Park, Soo-Jin Kang, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Circulation (2011)

This study sought to evaluate the clinical impact of angiographic complete revascularization (CR) after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary disease.A total of 1914 consecutive patients with multivessel coronary disease undergoing drug-eluting stent implantation (1400 patients) or coronary artery bypass graft surgery (514 patients) were enrolled. Angiographic CR was defined as revascularization in all diseased segments according to the Synergy Between PCI With Taxus and Cardiac Surgery classification. The outcomes of patients undergoing CR were compared with those undergoing incomplete revascularization (IR) after adjustments with the inverse-probability-of-treatment weighting method. Angiographic CR was performed in 917 patients (47.9%) including 573 percutaneous coronary intervention (40.9%) and 344 coronary artery bypass graft (66.9%) patients. CR patients were younger and had more extensive coronary disease than IR patients. Over 5 years, CR patients had comparable incidences of death (8.9% versus 8.9%; adjusted hazard ratio, 1.04; 95% confidence interval, 0.76 to 1.43; P=0.81), the composite of death, myocardial infarction, and stroke (12.1% versus 11.9%; adjusted hazard ratio, 1.04; 95% confidence interval, 0.79 to 1.36; P=0.80), and the composite of death, myocardial infarction, stroke, and repeat revascularization (22.4% versus 24.9%; adjusted hazard ratio, 0.91; 95% confidence interval, 0.75 to 1.10; P=0.32) compared with IR patients. However, 368 patients (19.2%) with multivessel IR had a greater tendency toward higher risk of death, myocardial infarction, stroke, or repeat revascularization (30.3% versus 22.1%; adjusted hazard ratio, 1.27; 95% confidence interval, 0.97 to 1.66; P=0.079) than those without multivessel IR.Angiographic CR with drug-eluting stent implantation or coronary artery bypass grafting did not improve long-term clinical outcomes in patients with multivessel disease. This finding supports the strategy of ischemia-guided revascularization.
Commentary: Unintended consequences of governance
Authors: B. Bridgewater
Journal: BMJ (2011)

Treasure and colleagues present data on the Ross operation and argue that it has a place for treating younger patients with aortic valve disease and may be a better option than surgery with conventional valves. Despite good reported short and longer term outcomes after the Ross procedure, they suggest that low volumes in the UK are due to intense scrutiny of mortality, which is driving surgeons to offer a treatment with the lowest procedural risk (which is measured) rather than the best overall lifetime risk to the patient (which is not). The arguments presented are around the Ross procedure, but the themes are generic and highlight concerns about the importance of using the “right” measures and possible unintended …
RADIATION DOSE REDUCTION IN PEDIATRIC CARDIAC COMPUTED TOMOGRAPHY: EXPERIENCE FROM A TERTIARY MEDICAL CENTER
Authors: Leif-Christopher Engel, Manavjot Sidhu, Ashley Lee, Suhny Abbara, Manudeep Kalra, Thomas J. Brady, Udo Hoffmann, Brian Ghoshhajra
Journal: Journal of the American College of Cardiology (2012)
Fatal Occupational Injuries
Authors: Susan Pardee Baker, J. S. Samkoff, R. S. Fisher, C. B. Van Buren
Journal: JAMA (1982)

Deaths resulting from work-related injuries during a one-year period in Maryland were identified and reviewed. Of 148 workers killed, all but two were male. Transportation vehicles were involved in 41% of the deaths, with road vehicles accounting for 25% of the total. Other major groups involved nonroad land vehicles (16%) and firearms, primarily handguns (11%). Two thirds of the workers died at the scene or were dead on arrival at the hospital. Head injuries were the most common cause of death. Eleven percent of the workers tested had blood alcohol concentrations of 0.08% by weight or greater. The majority of the deaths involved either hazards that are not addressed by the Occupational Safety and Health Act of 1970 or workers in categories that are excluded by law from regulation under this act.
Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
Authors: Susumu Ishida, Kenji Yamashiro, Tomohiko Usui, Yuichi Kaji, Yuichiro Ogura, Tetsuo Hida, Yoshihito Honda, Yoshihisa Oguchi, Anthony P Adamis
Journal: Nature Medicine (2003)
IS BACTERIUM ABORTUS PATHOGENIC FOR HUMAN BEINGS?
Authors: I. FOREST HUDDLESON
Journal: JAMA (1926)

The remarkable discovery made by Evans, 1 that the causative organism of undulant fever in man and that of Bang's abortion disease in cattle were similar if not identical, has brought forth considerable confirmatory evidence in this country and in Europe. These findings have served as a stimulus to observe more closely the possibility of man acquiring a fever from handling or ingesting material containing Bacterium abortus . Already many cases of illness in man in which the main symptom was characterized by recurrent fever have been cleared by the proper application of the knowledge that Evans has given us.  Cooledge 2 was probably the first to conduct experiments to determine the possibility of Bacterium abortus infecting man. At the time, he had no knowledge as to the relation of Micrococcus melitensis to Bacterium abortus , or what the nature of the disease would be if infection took place. The serologic tests
Abstract 4391: CD20 as a target for therapy in solid tumors
Authors: Nesrine I. Affara, Brian Ruffell, Magnus Johansson, Kerri Fujikawa, Emily Bergsland, David G. DeNardo, Heather I. Chen, Nikhil Wadhwani, Martin Steinhoff, Morgan Truitt, Peter Olson, Douglas Hanahan, Yijin Li, Qian Gong, Yan Ma, Jane F. Wiesen, Grace Kim, Margaret Tempero, Frances Balkwill, Bryan Irving, Lisa M. Coussens
Journal: Cancer Research (2012)

Abstract Using the K14-HPV16 mouse model of squamous carcinogenesis (SCC), we previously reported that B cells foster neoplastic progression through deposition of immunoglobulin complexes in premalignant tissue via Fcα receptor-dependent activation of recruited myeloid cells. Here we evaluated therapeutic interventions targeting these pathways in preclinical trials through administration of depleting αCD20 antibody and small molecule inhibitor of Syk kinase. Both approaches harbored efficacy in preventing premalignant progression to the dysplastic/carcinoma in situ state. Screening a diverse spectrum of human solid tumors revealed SCCs of the vulva, head and neck, as well as pancreatic ductal adenocarcinomas (PDAC) as scoring positively for “signatures” of B cell or plasma cell infiltration, i.e. Ig or CD20 mRNA expression, thereby identifying carcinomas potentially amenable to anti-B cell therapies. Accordingly, B cell-deficient mice failed to support growth of either transplantable orthotopic SCC or PDAC. While administration of αCD20 mAB as a single agent was inefficient in impeding growth of preexisting SCCs, when delivered in combination with cytotoxic chemotherapy, e.g., paclitaxel, carboplatin or cisplatin, αCD20 mAb significantly improved chemotherapeutic response and improved survival by a mechanism dependent on CD8+ T cells. These data reveal that blocking protumorigenic programs regulating by humoral immunity, in combination with chemotherapy, effectively reprograms the tumor immune microenvironment and improves outcome. The authors acknowledge generous support from the NIH/NCI (R01CA130980, R01CA13256, R01CA140943, R01CA15531), the Department of Defense (W81XWH-09-1-0342, W81XWH-10-BCRP-EOHS-EXP) and the Susan G Komen Foundation (KG111084) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4391. doi:1538-7445.AM2012-4391
Left Bundle-Branch Block and the ECG in Diagnosis of Acute Myocardial Infarction—Reply
Authors: Michael G. Shlipak, Alan S. Go, Warren S. Browner
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Collagenisation of the Disse space in alcoholic liver disease.
Authors: H Orrego, A Medline, L M Blendis, J G Rankin, D A Kreaden
Journal: Gut (1979)

Collagenisation of the space of Disse was systematically assessed to determine its relationship to the clinical and histological manifestations of chronic alcoholic liver disease. Ninety-four chronic alcoholics who had been submitted to biopsy were assessed by clinical manifestations of hepatic dysfunction and by a 17-parameter Combined Clinical and Laboratory Index (CCLI). Liver biopsies were scored for light (LM) and electron-microscopy (EM) abnormalities using a universal scoring system for both. Thirty-five patients with normal liver histology (LM) had an average collagen score of 0.6 +/- 0.1. Twelve cirrhotic patients and 29 with fatty liver, both groups with mild clinical manifestations, did not differ significantly. In 18 cirrhotic patients and five with fatty liver, both groups having severe clinical manifestations, the mean scores were 2.1 +/- 0.8 (P less than 0.02) and 2.5 +/- 0.6 (P less than 0.01) respectively. Collagenisation also correlated with CCLI (P less than 0.001), serum bilirubin (P less than 0.001), serum aspartate transferase (SGOT) (P less than 0.003), and clinical evidence of portal hypertension and histological changes of necrosis, inflammation, and terminal hepatic vein sclerosis. These results suggest that collagenisation of the Disse space may be important in the pathogenesis of alcoholic liver disease.
Open Mesh versus Laparoscopic Mesh Repair of Inguinal Hernia
Authors: Leigh Neumayer, Anita Giobbie-Hurder, Olga Jonasson, Robert Fitzgibbons, Dorothy Dunlop, James Gibbs, Domenic Reda, William Henderson
Journal: New England Journal of Medicine (2004)

Repair of inguinal hernias in men is a common surgical procedure, but the most effective surgical technique is unknown.We randomly assigned men with inguinal hernias at 14 Veterans Affairs (VA) medical centers to either open mesh or laparoscopic mesh repair. The primary outcome was recurrence of hernias at two years. Secondary outcomes included complications and patient-centered outcomes.Of the 2164 patients who were randomly assigned to one of the two procedures, 1983 underwent an operation; two-year follow-up was completed in 1696 (85.5 percent). Recurrences were more common in the laparoscopic group (87 of 862 patients [10.1 percent]) than in the open group (41 of 834 patients [4.9 percent]; odds ratio, 2.2; 95 percent confidence interval, 1.5 to 3.2). The rate of complications was higher in the laparoscopic-surgery group than in the open-surgery group (39.0 percent vs. 33.4 percent; adjusted odds ratio, 1.3; 95 percent confidence interval, 1.1 to 1.6). The laparoscopic-surgery group had less pain initially than the open-surgery group on the day of surgery (difference in mean score on a visual-analogue scale, 10.2 mm; 95 percent confidence interval, 4.8 to 15.6) and at two weeks (6.1 mm; 95 percent confidence interval, 1.7 to 10.5) and returned to normal activities one day earlier (adjusted hazard ratio for a shorter time to return to normal activities, 1.2; 95 percent confidence interval, 1.1 to 1.3). In prespecified analyses, there was a significant interaction between the surgical approach (open or laparoscopic) and the type of hernia (primary or recurrent) (P=0.012). Recurrence was significantly more common after laparoscopic repair than after open repair of primary hernias (10.1 percent vs. 4.0 percent), but rates of recurrence after repair of recurrent hernias were similar in the two groups (10.0 percent and 14.1 percent, respectively).The open technique is superior to the laparoscopic technique for mesh repair of primary hernias.
First-line imatinib mesylate in patients with newly diagnosed accelerated phase-chronic myeloid leukemia
Authors: D Rea, G Etienne, F Nicolini, P Cony-Makhoul, H Johnson-Ansah, L Legros, F Huguet, M Tulliez, M Gardembas, K Bouabdallah, P Rousselot, J-M Cayuela, F Guilhot, F-X Mahon
Journal: Leukemia (2012)
Fc and C3 Receptors Induced by Herpes Simplex Virus on Cultured Human Endothelial Cells
Authors: Douglas B. Cines, Alan P. Lyss, Mahin Bina, Richard Corkey, Nicholas A. Kefalides, Harvey M. Friedman
Journal: Journal of Clinical Investigation (1982)

The mechanism by which immune complexes deposit in vascular tissue is uncertain. Several human viruses, including herpes simplex virus, have recently been demonstrated to replicate in human endothelial cells. Such viruses may injure vascular tissue and could play a role in the pathogenesis of immune complex deposition. Therefore, we studied the expression of receptors for immune complexes containing IgG and C3 on endothelial cells after infection with herpes simplex virus type I.Human umbilical vein endothelial cells were incubated with (51)Cr-labeled sheep erythrocytes sensitized with IgG, IgM, or IgM plus complement. Preferential binding of IgG or complement-coated erythrocytes to uninfected endothelial monolayers was not observed. In contrast, significant binding of erythrocytes coated with IgG or IgM plus complement was observed after viral infection. Phase-contrast and scanning electron microscopy demonstrated erythrocyte adherence around the infected endothelial cells in a rosette pattern. Binding of IgG-coated erythrocytes was fully inhibited by Fc (0.31 mg/ml) but not Fab' fragments of nonimmune IgG. Binding of complement-coated cells was unaffected by the presence of IgG (1 mg/ml). With purified individual components, binding of complement-coated erythrocytes depended on the presence and was proportional to the concentration of C3. Binding of IgG-or C3-coated cells was detected beginning 4 h after infection. These studies indicate that herpes simplex virus type I infection can induce IgG and C3 receptors on human endothelial cells. These receptors may promote the deposition of immune complexes in vascular tissue after certain viral infections.