A Spectrum of Myopathy Associated with Alcoholism
Authors: GERALD T. PERKOFF
Journal: Annals of Internal Medicine (1967)

Article1 September 1967A Spectrum of Myopathy Associated with AlcoholismI. Clinical and Laboratory FeaturesGERALD T. PERKOFF, M.D., F.A.C.P., MARCONI M. DIOSO, M.D., VIRGIL BLEISCH, M.D., GEORGE KLINKERFUSS, M.D.GERALD T. PERKOFF, M.D., F.A.C.P., MARCONI M. DIOSO, M.D., VIRGIL BLEISCH, M.D., GEORGE KLINKERFUSS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-481 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHepatic, neurologic, cardiac, hematologic, and metabolic abnormalities are generally accepted as frequent occurrences in people who drink alcoholic beverages (1-5) to excess. That muscle disease may occur in alcoholism is not as widely known. However, myoglobinuria with severe muscle tenderness and swelling, fever, increased levels of serum glutamic-oxalo-acetic transaminase (SGOT) and other enzymes, and, often, acute renal failure has been reported in several alcoholic patients after severe drinking bouts (6-11).More recently, we reported studies (12) of a similar but less severe syndrome characterized by muscle tenderness and cramps, increased serum creatine phosphokinase (CPK), and a diminished ability to increase...References1. RATNOFFPATEK ODAS: The natural history of Laennec's cirrhosis of the liver. Medicine (Balt.) 21: 207, 1942. CrossrefGoogle Scholar2. VICTORADAMS MRD: On the etiology of the alcoholic neurologic diseases with special reference to the role of nutrition. Amer. J. Clin. Nutr. 9: 379, 1961. CrossrefMedlineGoogle Scholar3. BRIGDEN W: Uncommon myocardial disease, the non-coronary cardiomyopathies. Lancet 2: 1179, 1959. Google Scholar4. SULLIVANHERBERT LWV: Suppression of hematopoiesis by ethanol. J. 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FAHLGRENHEDLUNDMARK HRC: Myonecrosis and myoglobinuria in alcohol and barbiturate intoxication. Acta Med. Scand. 158: 405, 1957. CrossrefMedlineGoogle Scholar11. HEDLUNDMARKFAHLGRENORELL RCHS: Acute muscular syndrome in chronic alcoholism. Acta Med. Scand. 171: 585, 1962. CrossrefMedlineGoogle Scholar12. PERKOFFHARDYVELEZ-GARCIA GTPE: Reversible acute muscular syndrome in chronic alcoholism. New Eng. J. Med. 274: 1277, 1966. CrossrefMedlineGoogle Scholar13. VELEZ-GARCIAHARDYDIOSOPERKOFF EPMGT: Cysteine-stimulated serum creatine phosphokinase: unexpected results. J. Lab. Clin. Med. 68: 636, 1966. MedlineGoogle Scholar14. EKBOMHEDKIRSTEINASTROM KRLK: Muscular affections in chronic alcoholism. Arch. Neurol. (Chicago) 10: 449, 1964. CrossrefMedlineGoogle Scholar15. SERRATRICETOGAROUX GMH: Chronic proximal syndromes of alcoholic etiology. (With respect to 14 cases.) [Fr.] Presse Med. 74: 1721, 1966. MedlineGoogle Scholar16. KLINKERFUSSBLEISCHDIOSOPERKOFF GVMMGT: A spectrum of myopathy associated with alcoholism. II. Light and electron microscopic observations. Ann. Intern. Med. 67: 493, 1967. LinkGoogle Scholar17. PHILLIPSPETERSVAN SLYKE RAJPDD: Quantitative Clinical Chemistry (Methods), vol. 2, Army edition. The Williams & Wilkins Co., Baltimore, 1943. Google Scholar18. PERKOFF GT: Acute and chronic myopathy in alcoholism (abstract). Clin. Res. 14: 179, 1966. Google Scholar19. NYGREN A: Serum creatine phosphokinase activity in chronic alcoholism, in connection with acute alcohol intoxication. Acta Med. Scand. 179: 623, 1966. CrossrefMedlineGoogle Scholar20. DRACHMANMURPHYNIGAMHILLS DBSRMPJR: "Myopathic" changes in clinically denervated muscle. Arch. Neurol. (Chicago) 16: 14, 1967. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, MissouriFrom the Washington University Medical Service and the Snodgras Laboratory, St. Louis City Hospital (Max C. Starkloff Division), and the Departments of Medicine, Pathology, and Neurology, Washington University School of Medicine, St. Louis, Mo.This study was supported by grants AM 08377, AM 10062, 5-SO-1 FR 538905, and FR-36, U. S. Public Health Service, Washington, D. C., and by a grant from the Institute of Medical Education and Research of the City of St. Louis, St. Louis, Mo.Portions of this study were presented at the Annual Meeting of the Western Society for Clinical Research, Carmel, Calif., January 29, 1966, and at the 48th Annual Session of the American College of Physicians, San Francisco, Calif., April 14, 1967.Requests for reprints should be addressed to Gerald T. Perkoff, M.D., St. Louis City Hospital, 1515 Lafayette Ave., St. Louis, Mo. 63104. 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PERKOFF, M.D., F.A.C.P. 1 September 1967Volume 67, Issue 3_Part_1Page: 481-492KeywordsAlcoholismHospital medicineMedical educationMedical servicesMusclesMyalgiaNeurologyPathology and laboratory medicineResearch laboratoriesSerum glutamic oxaloacetic transaminase Issue Published: 1 September 1967 CopyrightCopyright ©, 1967, by The American College of PhysiciansPDF DownloadLoading ...