tbuckley/cabot-search huggingface dataset:
Researchers grow new blood vessels in the heart
Authors: H. Bower
Journal: BMJ (1998)

German doctors have grown new blood vessels in human hearts using genetically engineered human growth factor. This is a clinical first that could transform treatment for ischaemic heart disease.

In a randomised controlled trial, researchers from the Fulda medical centre in Germany injected human growth factor FGF-I into the heart muscle of 20 patients undergoing bypass surgery for three vessel coronary artery disease ( Circulation 1998;97:645-50). All participants also had stenoses in peripheral …
Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.
Authors: P D Ponath, S Qin, D J Ringler, I Clark-Lewis, J Wang, N Kassam, H Smith, X Shi, J A Gonzalo, W Newman, J C Gutierrez-Ramos, C R Mackay
Journal: Journal of Clinical Investigation (1996)

The CC chemokine eotaxin, identified in guinea pigs and also recently in mice, may be a key element for the selective recruitment of eosinophils to certain inflamed tissues. Using a partial mouse eotaxin CDNA probe, the human eotaxin gene was cloned and found to be 61.8 and 63.2% identical at the amino acid level to guinea pig and mouse eotaxin. Human eotaxin protein was a strong and specific eosinophil chemoattractant in vitro and was an effective eosinophil chemoattractant when injected into the skin of a rhesus monkey. Radiolabeled eotaxin was used to identify a high affinity receptor on eosinophils (0.52 nM Kd), expressed at 4.8 x 10(4) sites per cell. This receptor also bound RANTES and monocyte chemotactic protein-3 with lower affinity, but not macrophage inflammatory protein-1 alpha. Eotaxin could desensitize calcium responses of eosinophils to RANTES and monocyte chemotactic protein-3, although RANTES was able to only partially desensitize eosinophil calcium responses to eotaxin. Immunohistochemistry on human nasal polyp with antieotaxin mAbs showed that certain leukocytes as well as respiratory epithelium were intensely immunoreactive, and eosinophil infiltration occurred at sites of eotaxin upregulation. Thus eotaxin in humans is a potent and selective eosinophil chemoattractant that is expressed by a variety cell types in certain inflammatory conditions.
Recurrent Hemoperitoneum in Women Receiving Continuous Ambulatory Peritoneal Dialysis
Authors: John D. Harnett, Deborah Gill, Linda Corbett, Patrick S. Parfrey, Henry Gault
Journal: Annals of Internal Medicine (1987)

Of 27 women in the reproductive age group receiving continuous ambulatory peritoneal dialysis for more than 3 months, 4 of 7 who menstruated developed recurrent hemoperitoneum. Tubal ligation had been done in 3 of these 4 women. There were 37 episodes of hemoperitoneum; 22 occurred at midcycle and 15 with menstruation. One patient required repeated blood transfusion, but after oral anovulant therapy no further bleeding occurred and no transfusion was required. Two patients needed laparotomy: one for heavy intraperitoneal bleeding originating from a luteal cyst, and the other for severe lower abdominal pain from follicular and luteal cysts. Ultrasound examinations suggested the presence of small ovarian cysts in the two remaining patients. Recurrent midcycle hemoperitoneum in women on continuous ambulatory peritoneal dialysis may be triggered by ovulation and associated ovarian cyst formation. Suppression of ovulation should be considered.
Attentional deficit versus impaired reality testing: What is the role of executive dysfunction in complex visual hallucinations?
Authors: Ralf-Peter Behrendt
Journal: Behavioral and Brain Sciences (2005)

A “multifactorial” model should accommodate a psychological perspective, aiming to relate the phenomenology of complex visual hallucinations not only to neurobiological findings but also an understanding of the patient's psychological problems and situation in life. Greater attention needs to be paid to the role of the “lack of insight” patients may have into their hallucinations and its relationship to cognitive impairment.
Endoscopic full-thickness plication (Plicator) with two serially placed implants improves esophagitis and reduces PPI use and esophageal acid exposure
Authors: D. von Renteln, U. Brey, B. Riecken, K. Caca
Journal: Endoscopy (2008)

See also: Commentaire de travail de D. von Renteln et al., pp. 173Endoscopy 2008; 40(03): 355-355DOI: 10.1055/s-0032-1306811
Cancer Now Leading Cause of Death in US Hispanics
Authors: Rebecca Voelker
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMPARISON OF RENALGUARD SYSTEM, CONTINUOUS VENOVENOUS HEMOFILTRATION AND HYDRATION IN HIGH-RISK PATIENTS FOR CONTRAST-INDUCED NEPHROPATHY
Authors: Luca Bertelli, Luigi Politi, Sara Roversi, Ylenia Bartolacelli, Salvatore perrone, Giuseppe Biondi Zoccai, Francesca Bursi, Giuseppe M. Sangiorgi, Maria Grazia Modena
Journal: Journal of the American College of Cardiology (2012)
The Role of Prolactin in Mammary Carcinoma
Authors: Charles V. Clevenger, Priscilla A. Furth, Susan E. Hankinson, Linda A. Schuler
Journal: Endocrine Reviews (2003)

The contribution of prolactin (PRL) to the pathogenesis and progression of human breast cancer at the cellular, transgenic, and epidemiological levels is increasingly appreciated. Acting at the endocrine and autocrine/paracrine levels, PRL functions to stimulate the growth and motility of human breast cancer cells. The actions of this ligand are mediated by at least six recognized PRL receptor isoforms found on, or secreted by, human breast epithelium. The PRL/PRL receptor complex associates with and activates several signaling networks that are shared with other members of the cytokine receptor superfamily. Coupled with the recently identified intranuclear function of PRL, these networks are integrated into the in vitro and in vivo actions induced by ligand. These findings indicate that antagonists of PRL/PRL receptor interaction or PRL receptor-associated signal transduction may be of considerable utility in the treatment of human breast cancer.
Balloon-assisted enteroscopy: unifying double-balloon and single-balloon enteroscopy
Authors: K. Mönkemüller, L. Fry, M. Bellutti, P. Malfertheiner
Journal: Endoscopy (2008)

Tsujikawa and colleagues have presented a new technique for performing enteroscopy, namely "single-balloon enteroscopy" (SBE) [1]. This technique expands our endoscopic possibilities of exploring and treating diseases of the small bowel. A SBE technique may also be useful to investigate the colon or perform endoscopic retrograde cholangiopancreatography in patients with Roux-en-Y anatomy [2] [3]. Yamamoto et al. described the technique of double-balloon enteroscopy (DBE) in 2001 [4]. Both DBE and SBE have replaced push enteroscopy as the methods of choice for performing deep small-bowel investigation and for carrying out endoscopic interventions within the small intestine. Both SBE and DBE, like push enteroscopy, use the principle of the push-and-pull technique: the endoscope is advanced (pushed), then the overtube is slid towards the tip of the endoscope, and then both endoscope and overtube are pulled back, hence "push and pull".
Diagnosis of active and latent tuberculosis: summary of NICE guidance
Authors: I. Abubakar, C. Griffiths, P. Ormerod
Journal: BMJ (2012)

Tuberculosis is a major preventable infectious cause of morbidity and mortality globally, which has re-emerged in high risk groups such as migrants, homeless people, problem drug users, and prisoners in the UK.1 This article summarises the most recent recommendations (2011) from the National Institute for Health and Clinical Excellence (NICE)2 on the diagnosis of latent tuberculosis (including the use of new tests) and of active tuberculosis. Although this summary focuses on diagnosis, the full guidelines cover the public health and clinical management of tuberculosis and replaced the guidelines published in 2006.3 NICE recommendations are based on systematic reviews of best available evidence and explicit consideration of cost effectiveness. When minimal evidence is available, recommendations are based on the Guideline Development Group’s experience and opinion of what constitutes good practice. Evidence levels for the recommendations are given in italic in square brackets. ### Diagnosing latent tuberculosis (New/updated recommendations) #### All contacts of tuberculosis cases, aged 5 years or older #### Household contacts aged 2–5 years
Making Decisions About the Forgoing of Life-sustaining Therapy
Authors: JOHN M. LUCE
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

The incidence of withholding and withdrawal of life support from critically ill patients has increased to the extent that these practices now precede well over half of all deaths in many intensive care units (ICUs). Although the forgoing of life-sustaining therapy is ethically acceptable and clinically desirable in certain instances, and although physicians do not have a responsibility to provide futile care even if a patient or surrogate insists on it, they must be cautious in exercising their influence, if not authority, over patients and surrogates in prompting the withholding and withdrawal of life support. Such caution is particularly indicated because managed care has made patients suspicious of health-care institutions and physicians who are rewarded for restricting access to care. Most patients and surrogates agree with reasonable physician recommendations to forgo life-sustaining therapy. When they do not agree, physicians should not limit care on the basis of their own personal notions of futility, but should instead rely on institutional or multiinstitutional futility policies. Such policies should be developed by health professionals, patients, community leaders, and, when appropriate, participants in managed-care organizations. They should specify which ICU interventions are beneficial, address potential conflicts of interest, and be available to persons who could use such information in selecting the source of their care.
Collateral ventilation and gas exchange in emphysema.
Authors: N W Morrell, B K Wignall, T Biggs, W A Seed
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Resistance to collateral flow of gas is high in the normal human lung but may be lower in emphysema. However, the contribution of collateral ventilation to gas exchange in emphysema remains unclear. This study evaluates the role and magnitude of collateral ventilation between bronchopulmonary segments in six patients with clinical, functional, and computed tomographic evidence of emphysema, compared with our previous findings in 12 normal subjects. To assess collateral flow, a balloon-tipped catheter with a lumen that opened distal to the balloon was inflated in segmental bronchi during fiberoptic bronchoscopy. Respiratory gas tensions were sampled by mass spectrometer from beyond the occlusion via the catheter lumen. Subjects breathed air until occlusion was established and then switched to 79% helium/21% oxygen. The rate of rise of helium concentration was measured within occluded segments and used as an index of collateral ventilation. The mean (+/- SEM) rate of rise of helium concentration was ten times greater in emphysema patients (9.5 +/- 2.7%/min) compared with normal subjects (0.8 +/- 0.3%/min) (p = 0.009). The mean PO2 within occluded segments was similar in normal subjects and emphysema patients: 45.4 +/- 1.8 mm Hg and 44.8 +/- 3.6 mm Hg, respectively. Mean PCO2 within occluded segments was lower in patients (40.1 +/- 1.9 mm Hg) than in normal subjects (46.4 +/- 1.3 mm Hg), probably due to higher regional ventilation-perfusion ratios in emphysema patients rather than collateral ventilation. In emphysema patients there was a positive correlation between rate of rise of helium concentration and final PO2 within an occluded segment (r = 0.73; p = 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
THE KANSAS CITY CARDIOMYOPATHY QUESTIONNAIRE PREDICTS LONG-TERM MORTALITY AND HEART FAILURE REHOSPITALIZATION IN AFRICAN AMERICAN PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE
Authors: Sirikarn Napan, M. Tarek Alahdab, Ibrahim N. Mansour, John H. Stroger
Journal: Journal of the American College of Cardiology (2010)
Clobetasol propionate 0.05% cream in the treatment of vulvar lichen sclerosus: effect on the immunohistological profile
Authors: P. Carli, A. Cattaneo, B. Giannotti
Journal: British Journal of Dermatology (1992)

Journal Article Clobetasol propionate 0·05% cream in the treatment of vulvar lichen sclerosus: effect on the immunohistological profile Get access P. Carli, P. Carli Department of Dermatology, University of Florence, Italy Dr P. Carli, Clinica Dermatologica II, via della Pergola 58, 50121, Florence, Italy Search for other works by this author on: Oxford Academic Google Scholar A. Cattaneo, A. Cattaneo Department of Obstetrics and Gynaecology, University of Florence, Italy Search for other works by this author on: Oxford Academic Google Scholar B. Giannotti B. Giannotti Department of Dermatology, University of Florence, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 5, 1 November 1992, Pages 542–543, https://doi.org/10.1111/j.1365-2133.1992.tb14858.x Published: 01 November 1992
Abstract 1148: Development and validation of a second generation microRNA-based assay for diagnosing tumor tissue origin
Authors: Shai Rosenwald, Tina Edmonston, Iris Barshack, Meora Feinmesser, Monica Huszar, Wolf Mueller, Franz Fogt, Yael Spector, Ranit Aharonov, Eti Meiri
Journal: Cancer Research (2011)

Abstract Background: Cancer of unknown primary (CUP) constitutes 3%-5% of all newly diagnosed cancer cases. It presents a major diagnostic challenge due to the therapeutic implications of the tissue origin of the cancer. MicroRNAs are a family of non-coding, regulatory RNA genes that are involved in development, differentiation and cell cycle and were shown to be involved in oncogenesis. MicroRNAs are highly tissue-specific and therefore ideal candidates for CUP diagnosis. We have previously presented a biologically-motivated classification assay to identify the tissue of origin using a set of 48 microRNAs measured on a qRT-PCR platform. This assay can differentiate 25 different tumor types from 17 origins. We present here the development and validation of a second generation assay that can identify 42 different tumor types using a custom array platform. Methods: Over 1200 primary and metastatic tumor FFPE samples were used for the training and development of the assay. High-quality RNA, including the well-preserved microRNA fraction, was extracted from the FFPE blocks using proprietary protocols. Expression levels of all known and additional Rosetta's proprietary microRNAs were profiled using a custom array platform. A combination of a decision tree classifier with a KNN classifier was developed to identify the tissue of origin based on the microRNA expression patterns. A validation set of more than 500 independent FFPE samples of primary tumors and metastases was analyzed blindly and classified using the developed assay. Results: The assay is able to identify 42 tumor types based on the expression of only several dozens microRNAs with very high accuracy. Based on the validation set, the sensitivity (positive agreement) for identifying the tumor origin is 85%. In more than 80% of the cases, a single answer was reported, and for these cases, the sensitivity is 90%. Conclusions: Previous studies have highlighted the tissue-specificity of microRNA expression, and have demonstrated their potential use for classification of human malignancies. An assay utilizing microRNA expression in paraffin-embedded tissue for identification of the tissue of origin was previously developed. Here we present the development and the performance of a second generation assay, designed to identify 42 tumor types. This assay will provide an important new tool for diagnosing tumor tissue origin. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1148. doi:10.1158/1538-7445.AM2011-1148
Who Should Do the Coding?-Reply
Authors: Susan Lloyd
Journal: JAMA (1986)

<h3>In Reply.—</h3> We disagree with Dr Solomkin that the missing information discovered in our study is an administrative problem. Improvement in data bases such as the Veterans Administration's Patient Treatment File requires support from both clinical and administrative services. We attempted to attribute errors to their source. Coding is based on the Discharge Summary and Operative Reports. Because the physician is responsible for these documents, we considered missing information in these reports to be the physician's responsibility. Using Dr Solomkin's example of benign hypertension, we do not agree that it is an insignificant diagnosis. Furthermore, it is not appropriate to make an administrative decision that a patient had hypertension and to add it to the discharge summary. We agree that many of the omissions found were of lesser significance. However, many were important, both clinically and financially. Our protocol for inclusion of a diagnosis was that it was treated, that
Causes of venous ulceration: a new hypothesis
Authors: P D C. Smith, P Thomas, J H Scurr, J A Dormandy
Journal: BMJ (1988)

Previous hypotheses about the causes of venous ulceration are inconsistent with recently published data. In patients with chronic venous insufficiency the number of functioning capillary loops visible in the skin on microscopy fell after the legs had been dependent for 30 minutes. Another study had shown that leucocytes became trapped in the circulation in dependent legs. A new hypothesis linking these two findings proposes that the trapped white cells occlude the capillaries and result in ischaemia of the skin of the leg.
The Effects of Regulation, Competition, and Ownership on Mortality Rates among Hospital Inpatients
Authors: S M Shortell, E F Hughes
Journal: New England Journal of Medicine (1988)

We examined the influence of the regulation of hospital rates, state certificate-of-need programs, competition, and hospital ownership on mortality rates among inpatients receiving care under Medicare for 16 selected clinical conditions that were studied as a group. Data were obtained from the records of 214,839 patients who received care in 981 hospitals in 45 states from July 1, 1983, through June 30, 1984. We found significant associations between higher mortality rates among inpatients and the stringency of state programs to review hospital rates (P less than or equal to 0.05), the stringency of certificate-of-need legislation (P less than or equal to 0.01), and the intensity of competition in the marketplace, as measured by enrollment in health maintenance organizations (P less than or equal to 0.05). Hospitals in the states with the most stringent review procedures for hospital rates had ratios of actual to predicted death rates that were 6 to 10 percent higher than those of hospitals in states with less stringent rate-review programs (P less than or equal to 0.001). Hospitals in the states with the most stringent procedures for reviewing applications for certificates of need had ratios of actual to predicted death rates that were 5 to 6 percent higher than those of hospitals in states with less stringent certificate-of-need procedures (P less than or equal to 0.05). There was no statistically significant association between mortality rates among inpatients and either the type of hospital ownership or the number of hospitals competing in the market area. Additional analyses, which examined alternative explanations for these findings, failed to change the results. These findings raise serious concerns about the welfare of patients who are admitted to hospitals in highly regulated areas and those admitted to hospitals in relatively competitive markets. They suggest that it is important to incorporate quality-assurance procedures and systems to monitor patients' outcomes into public and private programs designed to contain costs or promote competition, or both.
Glomerulonephritis as a Complication of the Schönlein — Henoch Syndrome
Authors: Leon M. Levitt, Benjamin Burbank
Journal: New England Journal of Medicine (1953)

RENAL bleeding, either gross or microscopic, is a fairly frequent manifestation of the Schönlein–Henoch syndrome. Usually, it is ascribed to the increased capillary permeability that is one of the features of this illness. However, in 1852, Johnson1 noted the association of purpura with renal disease and albuminuria. Since then, the occurrence of glomerulonephritis as a visceral complication along with or in the wake of allergic purpura, erythema or edema has been a controversial issue. In 1899 Henoch2 referred to nephritis as a frequent complication of the syndrome and reported 3 such cases. Osler,3 , 4 Pratt5 and Lippman6 described classic glomerulonephritis in . . .
STUDIES ON THE PATHOGENESIS OF FEVER
Authors: Richard D. Berlin, W. Barry Wood
Journal: The Journal of Experimental Medicine (1964)

The metabolic reactions responsible for the release of endogenous pyrogen from rabbit granulocytes incubated in 0.15 M NaCl are specifically inhibited by the presence of K(+) (and by related alkali metal ions, Rb(+) and Cs(+)) in the medium. The inhibitory action of K(+) apparently involves penetration of the cell membrane and is directly antagonized by the cardiac glycoside, ouabain. It is concluded, therefore, that the inhibition of pyrogen release by extracellular K(+) is due to transport of K(+) into the cell. Although the precise molecular mechanisms which are responsible for the release of pyrogen from granulocytes incubated in K-free saline have not been elucidated, further study of the process has revealed: (a) that it is preceded by the accumulation of pyrogen within the cell, (b) that it depends upon the catalytic action of one or more sulfhydryl-containing enzymes, (c) that it does not require energy, either from glycolysis or from reactions depending on molecular oxygen, and (d) that its inhibition by K(+) and by arsenite is qualitatively similar to the depression caused by these same reagents on the release of other leucocytic proteins; i.e., lysozyme and aldolase.
Laparoscopic sterilisation with silastic-band technique.
Authors: A A Templeton, M G Kerr, R A Cole, M M Lees
Journal: BMJ (1977)

Ssi of the remaining seven patients and "improved" in the other one.Side- effects necessited neither interruption of treatment nor delay in discharge from hospital. CommentWe have found this technique of female sterilisation easy to learn and technically as simple as laparoscopic tubal diathermy.It seems to