tbuckley/cabot-search huggingface dataset:
Testing Mealey's model: The need to demonstrate an ESS and to establish the role of testosterone
Authors: John Archer
Journal: Behavioral and Brain Sciences (1995)

Abstract Two specific aspects of Mealey's model are questioned: (1) the application of the concept of Evolutionarily Stable Strategy to all alternative strategies, including those that involve reduced lifetime reproductive success; and (2) the evidence for the dual role of testosterone, which is based mainly on studies of a modulating effect on aggression.
Renal Function Studies using 99mTc-Dimercaptosuccinic Acid
Authors: JUICHI KAWAMURA, SHINICHI HOSOKAWA, OSAMU YOSHIDA
Journal: Clinical Nuclear Medicine (1979)

99mTc-dimercaptosuccinic acid (DMSA), provides both a well defined renal image via preferential cortical accumulation, and a quantitative assessment of separate kidney function, correlating well with renal plasma flow obtained from the 131I-Hippuran renogram of each kidney. 99mTc-DMSA is capable of labeling the functioning nephrons in the cortex without interference by the activity of urine flow, suggesting that DMSA should be termed a cortical tubular marker. 99mTc-DMSA scintigraphy has advantages over conventional methods in that it can be performed repeatedly with little discomfort to the patient, as a routine clinical examination.
PM-14 * A PIGGYBAC TOOLKIT FOR RAPID TESTING OF PUTATIVE PEDIATRIC GBM DRIVER GENES WITH EXTENSIONS FOR INVESTIGATING CELLS OF RECURRENCE
Authors: J. Breunig, R. Levy, C. D. Antonuk, J. Molina-Aravena, M. Dutra-Clarke, A. Akhtar, G. B. Kim, H. Park, M. Danielpour
Journal: Neuro-Oncology (2015)

We have created a novel method for studying glioma initiation, progression, and recurrence with in vivo-postnatal electroporation combined with piggyBac transposition. Electroporation allows for rapid addition of transgenes, simply by the inclusion of plasmid DNA in the initial injection. Thus, we have created a toolkit for interrogating the resulting tumor cells in vivo. Specifically, we have created piggyBac plasmids expressing a spectrum of transgenes or elements for modeling recently discovered and previously identified pediatric driver mutations, including H3.3, Atrx, Trp53, Nf1, and Pdgfra . Here we detail the use of these elements with additional transgenes for non-invasive imaging and inducible cell ablation. Further, we are investigating the use of novel methods for genetically labeling quiescent and recurrent cells, including inducible and reversible transgenic systems. Here we discuss these methodologies and their use in the context of our novel pediatric glioma models with a focus on emergent properties from different driver gene combinations.
Comparative efficacy of three mumps vaccines during disease outbreak in eastern Switzerland: cohort study
Authors: M. Schlegel, J. J Osterwalder, R. L Galeazzi, P. L Vernazza
Journal: BMJ (1999)

sonality, communication skills, and interest in medical topics are assessed and scored.Offers are made to the 260 interviewees with the top scores.In 1997, 2701 candidates from the United Kingdom and the rest of the European Union applied to Nottingham through the Universities Colleges and Admission Service.The decision for each applicant was noted along with ethnic group, sex, and stage of the process.Statistical comparison of frequencies was by 2 test with Yates's correction.Significantly more non-white and male applicants were rejected at the academic and questionnaire stages, whereas significantly more white and female applicants were rejected at the statement review and interview stages (table).The net effect was that significantly more white and female applicants were offered a place.
Constraints on the definitions of “unique hues” and “opponent channels”
Authors: Carl R. Ingling
Journal: Behavioral and Brain Sciences (1997)

Zone theories of color vision transform cone sensitivities to channel sensitivities before transmitting these signals to the brain. The concepts of “unique hue” and “color opponency” are fundamental to an understanding of this transformation. Saunders &amp; van Brakel question the objectivity of these concepts. Statements in their target article indicate that the reason for this questioning stems from a failure to appreciate the constraints inherent in the definitions of these concepts.
Open your eyes to Africa
Authors: Jocalyn Clark
Journal: BMJ (2005)

Africa is big, complex, and confounding. The ambivalence of looking towards a future full of promise but uncertainty is captured in our cover image—that of a child shielding his eyes in front of a Malian textile containing eyes wide open. Achieving a successful future is by no means a task for Africa alone, and the BMJ is contributing through this week's theme issue.

But can we do justice to a continent as richly diverse as Africa? We will present this theme issue to the 53 African Union health ministers …
129 PREDICTIVE FACTORS, NATURAL HISTORY AND OUTCOME OF CHRONIC HEPATITIS E VIRUS INFECTION IN SOLID-ORGAN-TRANSPLANT PATIENTS: A RETROSPECTIVE MULTICENTER STUDY
Authors: N. Kamar, E.B. Haagsma, V. Garrigue, S. Pischke, C. Chauvet, J. Dumortier, A. Cannesson, E. Cassuto-Viguier, E. Thervet, F. Conti, P. Lebray, H.R. Dalton, R. Santella, N. Kanaan, M. Essig, C. Mousson, S. Radenne, A.M. Roque-Afonso, J. Izopet, L. Rostaing
Journal: Journal of Hepatology (2011)
Pediatric Rapid Response Teams
Authors: Jeffrey E. Nowak, Richard J. Brilli
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Donald Cooper: coping with the new 'fitness'
Authors: Phil Gunby
Journal: JAMA (1979)

Nearly half of all Americans regardless of age and sex are becoming involved in the "exercise surge." To size up the significance of this new American approach to fitness,<i>JAMA</i>MEDICAL NEWS talked with Donald L. Cooper, MD, director of Student Health Services and team physician at Oklahoma State University, Stillwater. A trainer for more than seven years before he went to medical school, Cooper also was the last physician to chair the AMA's Committee on the Medical Aspects of Sports before it was disbanded in January 1977. The 50-year-old Cooper himself briskly walks at least 4 km within a half-hour period on one or more occasions daily, shuns elevators in favor of stairs, and makes it a point to "get up from his desk and move around a lot." Asked whether the exercise surge will last, Cooper concedes that Americans seem to have a short attention span. So the
A biopsy-based quick test in the diagnosis of duodenal hypolactasia in upper gastrointestinal endoscopy
Authors: M. Kuokkanen, M. Myllyniemi, M. Vauhkonen, T. Helske, I. Kääriäinen, S. Karesvuori, A. Linnala, M. Härkönen, I. Järvelä, P. Sipponen
Journal: Endoscopy (2006)

Background and study aims: The usefulness of a new quick test for endoscopic diagnosis of adult-type hypolactasia was tested in duodenal biopsies. In this test, an endoscopic biopsy from the postbulbar duodenum is incubated with lactose on a test plate, and a color reaction develops within 20 min as a result of hydrolyzed lactose (a positive result) in patients with normolactasia, whereas no reaction (a negative result) develops in patients with severe hypolactasia. Patients and methods: Two postbulbar duodenal biopsies were taken from 80 prospectively enrolled adult outpatients with dyspepsia. The biopsies were used for the Quick Lactase Test (Biohit PLC, Helsinki, Finland) and in biochemical disaccharidase (lactase, sucrase, and maltase) assays. In addition, the C/T-13 910 genotype was determined from DNA extracted from gastric antral biopsies using polymerase chain reaction sequencing in genomic analysis of adult-type hypolactasia. Results: Twenty-one of 22 patients (95 %; 95 % CI, 87 - 100 %) with biochemical lactase activity < 10 U/g protein, but none of the 58 patients with lactase activity of 10 U/g protein or more had a negative result in the Quick Lactase Test. Seven of the 80 patients (9 %; 95 % CI, 3 - 15 %) had a Quick Lactase Test result that indicated mild hypolactasia (a mild color reaction). All patients with celiac disease (n = 6) had a negative Quick Lactase Test result. Nine of 74 patients (six patients with celiac disease were excluded) had a CC-13 910 genotype in genomic testing, indicating adult-type hypolactasia. All of them had negative test results with the Quick Lactase Test. Twenty-six patients had a TT genotype, indicating normolactasia, and none of these patients had a negative test result in the Quick Lactase Test. Six of 39 patients (15 %; 95 % CI, 4 - 27 %) with a CT genotype had a negative result in the Quick Lactase Test. Conclusions: The Quick Lactase Test effectively identifies patients with severe duodenal hypolactasia. In comparison with CC (adult-type hypolactasia) and TT individuals (normolactasia), the sensitivity and specificity of the Quick Lactase Test result was 100 %. In comparison with biochemical lactase assays, the sensitivity and specificity of a negative Quick Lactase Test for indicating hypolactasia (lactase activity < 10 U/g protein) were 95 % (95 % CI, 87 - 100 %) and 100 %, respectively.
A study of persistent photosensitivity as a sequel of the prior administration of the drug benoxaprofen
Authors: W. FRAIN-BELL
Journal: British Journal of Dermatology (1989)

Cutaneous photosensitivity is a recognized side-effect of a number of commonly used groups of drugs, among which are the non-steroidal anti-inflammatory agents (NSAIDs) one of which, benoxaprofen, was withdrawn from use in 1982. The abnormal reaction of the skin to light usually occurs during the period of the systemic administration of the drug, but may with some drugs persist for longer, even for months. Chronic photosensitivity, i.e.'persistent light reaction' of some years duration, continuing after the withdrawal of the primary cause, has so far only been reliably reported when the initial exposure of the skin to the photoactive substance has been by external contact and not following ingestion. A suggestion that photosensitivity could persist for a period of years as a sequel of initial benoxaprofen-induced photosensitivity was studied in a group of 42 subjects said to be affected in this way. The results failed to confirm the presence of persistent photosensitivity. It appeared that the probable explanation for the episodic abnormal reactions to light over the years since 1982 was the systemic administration of other photoactive drugs including a series of NSAIDs.
Lethal vascular leak syndrome after denileukin diftitox administration to a patient with cutaneous gamma/delta T‐cell lymphoma and occult cirrhosis
Authors: Andrew B. Avarbock, Alison W. Loren, Jason Y. Park, Jacqueline M. Junkins‐Hopkins, John Choi, Leslie A. Litzky, Alain H. Rook
Journal: American Journal of Hematology (2008)

Abstract Denileukin diftitox (Ontak) is an immunotoxin used in the treatment of cutaneous T‐cell lymphomas. Vascular leak syndrome is a known complication of this therapy, although the syndrome is most often self‐limited. We report the case of a patient with cutaneous gamma/delta (γδ) T‐cell lymphoma and previous undiagnosed liver disease treated with denileukin diftitox. Just 4 days after initiating drug therapy, the patient developed profound vascular leak syndrome characterized by a rapid fall in his previously normal serum albumin to levels below the limit of detection. The patient then quickly deteriorated into rhabdomyolysis and eventual death. To our knowledge, this is the first report of a death directly related to denileukin diftitox therapy. The purpose of this case is to increase awareness and improve management of patients who are treated with denileukin diftitox with resulting vascular leak syndrome leading to hypoalbuminemia. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
Mathematical models of the uptake of carbon monoxide on hemoglobin at low carbon monoxide levels.
Authors: R Joumard, M Chiron, R Vidon, M Maurin, J M Rouzioux
Journal: Environmental Health Perspectives (1981)

Coburn's differential equation for the uptake of carbon monoxide by hemoglobin and two particular types of solution of this equation were considered and the solutions verified for a group of healthy adults consisting of 73 nonsmoking pedestrians or car passengers exposed to low levels of carbon monoxide as experienced in the city of Lyon. The CO levels at the breathing level and the walking speed of the subjects was continually measured, and the carboxyhemoglobin levels determined at the beginning and the end of each test journey. The values of all the other relevant parameters were also determined. The half-life of carboxyhemoglobin was studied as a function of the degree of activity, the age, the sex and the height of the subjects. Finally a mathematical model was set up to represent a periodic uptake of CO which made it possible to estimate the variations in the carboxyhemoglobin level for any subject during a period of a day or a week without any need to know the initial level.
Early microvascular reflow status after infarct reperfusion determines outcome of postinfarction remodeling independent of myocardial salvage
Authors: Frank Bowen, Sina L. Moainie, Joseph H. Gorman, Ivan Salgo, T.Sloane Guy, Martin St. John-Sutton, L.Henry Edmunds, Robert C. Gorman
Journal: Journal of the American College of Cardiology (2002)
Octreotide for Diarrhea in Amyloidosis
Authors: Lung T. Yam, Socorro B. Oropilla
Journal: Annals of Internal Medicine (1991)

Letters1 October 1991Octreotide for Diarrhea in AmyloidosisLung T. Yam, MD, Socorro B. Oropilla, MDLung T. Yam, MDSearch for more papers by this author, Socorro B. Oropilla, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-7-577_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The somatostatin analog octreotide acetate (Sandostatin, Sandoz Pharmaceuticals, East Hanover, New Jersey) has been used to treat diarrhea associated with various disorders (1). We report the successful use of octreotide to treat intractable diarrhea in a patient with amyloidosis secondary to multiple myeloma.A 53-year-old man with multiple myeloma of the immunoglobulin G-kappa type was treated with melphalan-prednisone, and his hematologic status became stable. He was found to have polyneuropathy 14 months after the diagnosis of myeloma was made. Diarrhea, hepatomegaly, congestive heart failure, polyserositis, orthostatic hypotension, and periorbital bleeding were subsequently noted. Amyloidosis was diagnosed on...References1. GordenComiMatonGo PRPV. Somatostatin and somatostatin analogue (SMS 201-995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut. Ann Intern Med. 1989;110:35-50. LinkGoogle Scholar2. KyleGreipp RP. Amyloidosis (AL): clinical and laboratory features in 229 cases. Mayo Clin Proc. 1983;58:665-83. MedlineGoogle Scholar3. O'ConnorO'Dorisio CT. Amyloidosis, diarrhea, and a somatostatin analogue. Ann Intern Med. 1989;110:665-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Affairs Medical Center University of Louisville School of Medicine Louisville, KY 40206-1499 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySupportive Care for Patients with Systemic Light Chain AmyloidosisSupportive Care in AL AmyloidosisSystemic amyloidoses: What an internist should knowSuccessful treatment of protein-losing enteropathy due to AA amyloidosis with octreotide in a patient with rheumatoid arthritisSystemic AA AmyloidosisPharmacological Management of DiarrheaGastrointestinal Manifestations of AmyloidosisAmylose digestive (foie exclu)SYSTEMIC AMYLOIDOSIS AND THE GASTROINTESTINAL TRACTEndocarditis caused by Lactobacillus.Emergency blood test guidelines.Cardiopulmonary resuscitation.Octreotide therapy for diarrhoea.Clinical Applications of Gastrointestinal Hormones 1 October 1991Volume 115, Issue 7Page: 577-577KeywordsAmyloidosisDiarrheaHeart failureHemorrhageHepatomegalyHypotensionMultiple myelomaMyelomaSomatostatin Issue Published: 1 October 1991 PDF DownloadLoading ...
Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated with Sunitinib Response in the Metastatic Setting
Authors: Benoit Beuselinck, Sylvie Job, Etienne Becht, Alexandra Karadimou, Virginie Verkarre, Gabrielle Couchy, Nicolas Giraldo, Nathalie Rioux-Leclercq, Vincent Molinié, Mathilde Sibony, Reza Elaidi, Corinne Teghom, Jean-Jacques Patard, Arnaud Méjean, Wolf Herman Fridman, Catherine Sautès-Fridman, Aurélien de Reyniès, Stéphane Oudard, Jessica Zucman-Rossi
Journal: Clinical Cancer Research (2015)

Abstract Purpose: Selecting patients with metastatic clear-cell renal cell carcinoma (m-ccRCC) who might benefit from treatment with targeted tyrosine kinase inhibitors (TKI) is a challenge. Our aim was to identify molecular markers associated with outcome in patients with m-ccRCC treated with sunitinib. Experimental Design: We performed global transcriptome analyses on 53 primary resected ccRCC tumors from patients who developed metastatic disease and were treated with first-line sunitinib. We also determined chromosome copy-number aberrations, methylation status, and gene mutations in von Hippel–Lindau and PBRM1. Molecular data were analyzed in relation with response rate (RR), progression-free survival (PFS), and overall survival (OS). Validation was performed in 47 additional ccRCC samples treated in first-line metastatic setting with sunitinib. Results: Unsupervised transcriptome analysis identified 4 robust ccRCC subtypes (ccrcc1 to 4) related to previous molecular classifications that were associated with different responses to sunitinib treatment. ccrcc1/ccrcc4 tumors had a lower RR (P = 0.005) and a shorter PFS and OS than ccrcc2/ccrcc3 tumors (P = 0.001 and 0.0003, respectively). These subtypes were the only significant covariate in the multivariate Cox model for PFS and OS (P = 0.017 and 0.006, respectively). ccrcc1/ccrcc4 tumors were characterized by a stem-cell polycomb signature and CpG hypermethylation, whereas ccrcc3 tumors, sensitive to sunitinib, did not exhibit cellular response to hypoxia. Moreover, ccrcc4 tumors exhibited sarcomatoid differentiation with a strong inflammatory, Th1-oriented but suppressive immune microenvironment, with high expression of PDCD1 (PD-1) and its ligands. Conclusions: ccRCC molecular subtypes are predictive of sunitinib response in metastatic patients, and could be used for personalized mRCC treatment with TKIs, demethylating or immunomodulatory drugs. Clin Cancer Res; 21(6); 1329–39. ©2015 AACR.
Effect of tumor necrosis factor ? and intercellular adhesion molecule-1 expression on immunogenicity of murine liver cells in mice
Authors: Ginny L. Bumgardner, Jiashun Li, SACH APTE, MARIE HEININGER, WENDY L. FRANKEL
Journal: Hepatology (1998)

Adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) have been implicated in the pathogenesis of various inflammatory liver disease states, including viral and autoimmune hepatitis as well as liver allograft rejection. Tumor necrosis factor α (TNF-α) is an inflammatory cytokine known to up-regulate adhesion molecules as well as major histocompatibility complex (MHC) class I expression, and has been demonstrated to be important in the rejection of vascularized organ allografts. The current studies address the effect of TNF-α and the role of ICAM-1 expression on liver cell immunogenicity in vitro in mixed lymphocyte hepatocyte culture (MLHC), in vitro in mixed lymphocyte liver nonparenchymal cell culture (MLNPC), in vivo in hepatocyte sponge matrix allografts (HC-SMA), and in vivo in liver nonparenchymal cell sponge matrix allografts (NPC-SMA). Purified allogeneic hepatocytes (HC) and liver nonparenchymal cells (NPC) under naive, unstimulated conditions demonstrated different profiles of MHC antigen and adhesion molecule expression, but both liver cell populations stimulated the proliferation and development of allospecific cytotoxic effectors in vitro and in vivo . Despite significant up-regulation of MHC class I and ICAM-1 on both HC and liver NPCs by in vivo treatment with TNF-α, the immunogenicity of TNF-α-stimulated liver cells was not appreciably different from naive, unstimulated liver cells. In contrast, ICAM-1-negative HC and NPCs were significantly less immunogenic both in terms of lymphocyte proliferative responses and the generation of allospecific cytolytic effectors. These results suggest that constitutive expression of ICAM-1 enhances the immunogenicity of “donor” liver cells but is not absolutely required to elicit immune responses to allogeneic liver cells. Further studies to determine the role of adhesion molecule expression on trafficking of host immune cells to the liver and the role of adhesion molecule expression by host cells are required to clarify their role in immune responses to liver cells.
A double-blind trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer
Authors: J. M. Cliff, G. J. Milton-Thompson
Journal: Gut (1970)

A controlled trial of carbenoxolone sodium positioned-release capsules (Duogastrone) was carried out on a randomized series of 100 unselected male Service personnel with symptoms of active duodenal ulceration and supporting radiological evidence. Fifty-seven patients completed the trial, 29 in the carbenoxolone group and 28 in the control group. The carbenoxolone group was given capsules containing 50 mg carbenoxolone four times a day for 12 weeks while the controls received a capsule identical in every respect except that it did not contain carbenoxolone. All patients were assessed at fortnightly intervals and had clinical and radiological reassessments three and six months after commencing treatment. Review at three months and at six months revealed a slight but clinically insignificant trend in favour of the carbenoxolone group. As a corollary to this controlled trial, those patients (38 in all) who did not have an early remission of symptoms were removed from the trial and placed on capsules known to contain carbenoxolone. Subsequently these patients did not show an advantage for carbenoxolone.