Hepatic Injury Found during Chronic Chlorpromazine Therapy
Authors: LEO WAITZKIN
Journal: Annals of Internal Medicine (1962)

Article1 February 1962Hepatic Injury Found during Chronic Chlorpromazine TherapyPreliminary Clinical StudyLEO WAITZKIN, M.D., H. EDWARD MACMAHON, M.D.LEO WAITZKIN, M.D.Search for more papers by this author, H. EDWARD MACMAHON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-220 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn man, intrahepatic cholestasis is known to be induced sometimes by chlorpromazine during the early weeks of its administration, but its lengthy administration has not been reported to cause hepatic injury. We were led to investigate the possibility that chronic chlorpromazine therapy might damage the liver when we encountered fatty liver of obscure etiology in four patients receiving such therapy. Of interest in this regard was a recent report that prolonged treatment of rats with large doses of chlorpromazine caused fatty infiltration, necrosis, and mild degenerative changes in the liver parenchyma (1).Our first observations were made while hepatic function...References1. HORMIAHORMIAHAKOLA MAP: Effect of chlorpromazine and reserpine on liver parenchyma in the white rat. Ann. Med. Exp. Fenn. 35 (Fasc. 3): 316, 1957. MedlineGoogle Scholar2. HANGER FM: The flocculation of cephalin-cholesterol emulsions by pathological sera. Trans. Ass. Amer. Physicians 53: 148, 1938. Google Scholar3. MACLAGAN NF: Thymol turbidity test: a new indicator of liver dysfunction. Brit. J. Exp. Path. 25: 234, 1947. Google Scholar4. KUNKEL HG: Estimation of alterations of serum gamma globulin by turbidimetric technique. Proc. Soc. Exp. Biol. Med. 66: 217, 1947. CrossrefMedlineGoogle Scholar5. ROSENTHALWHITE SMEC: Clinical applications of bromsulfalein test for hepatic function. J. A. M. 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EDWARD MACMAHON, M.D.Affiliations: Brockton, MassachusettsFrom the Medical Service, Veterans Administration Hospital, Brockton, Massachusetts, and the Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts.Requests for reprints should be addressed to Leo Waitzkin, M.D., Veterans Administration Hospital, Brockton 1, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChanges in liver lipids after administration of 2-decanoylamino-3-morpholinopropiophenone and chlorpromazineEffect of chlorpromazine on the function of the perfused isolated liverPhenothiazinesBivirkninger og komplikasjoner ved lang-tidsbehandling med psykofarmakaCholestatischer IkterusCholestatic Drugs and Bilirubin MetabolismInhibition of Lipase Activity of Lung and Adipose Tissue by Phenothiazine DerivativesTHE HISTOPATHOLOGY OF DRUG-INDUCED LIVER DISEASEPhenothiazine und Azaphenothiazine als Heilmittel 1 February 1962Volume 56, Issue 2Page: 220-232KeywordsChlorpromazineEtiologyFatty liverHospital medicineLiverMedical servicesNecrosisSodium ePublished: 1 December 2008 Issue Published: 1 February 1962 PDF downloadLoading ...