Factors Determining the Outcome of Chemotherapy in Infections of the Urinary Tract
Authors: ROBERT I. LINDEMEYER
Journal: Annals of Internal Medicine (1963)

Article1 February 1963Factors Determining the Outcome of Chemotherapy in Infections of the Urinary TractROBERT I. LINDEMEYER, M.D., MARVIN TURCK, M.D., ROBERT G. PETERSDORF, M.D., F.A.C.P.ROBERT I. LINDEMEYER, M.D.Search for more papers by this author, MARVIN TURCK, M.D.Search for more papers by this author, ROBERT G. PETERSDORF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-2-201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe treatment of urinary tract infections has been generally unsatisfactory, and the long histories of repeated instrumentation and multiple courses of antimicrobial therapy interspersed with flare-ups characterized by classical symptoms of "cystitis" or "pyelonephritis" offered by these patients attest to the refractoriness of these infections. Why infections of the urinary tract have been so notoriously resistant to attack with both medical and surgical therapeutic maneuvers is not entirely clear. Among the possible reasons are: failure to remedy obstruction to urine flow; emergence of antibiotic resistant mutants during or after treatment; presence of "mixed infections" in which only the sensitive pathogens...References1. SchaubFoleyScottBailey IGMKEGWR Diagnostic Bacteriology, Edited by , The C. V. Mosby Company, St. Louis, 1958, chap. 6. Google Scholar2. EDWARDSEWING PRWH: In Identification of Enterobacteriaceae, Burgess, Minneapolis, 1955, pp. 137-160. Google Scholar3. TURCKLINDEMEYERPETERSDORF MRIRG: Comparison of single-disc and tubedilution techniques in determining antibiotic sensitivities of Gram-negative pathogens. Ann. Intern. Med.: 58, March, 1963. Google Scholar4. PETERSDORFHOOKCURTINGROSSBERG RGEWJASE: The antimicrobial sensitivity of gram-negative pathogens. Bull. Johns Hopkins Hosp. 108: 48, 1961. MedlineGoogle Scholar5. TURCKLINDEMEYERPETERSDORF MRIRG: Evaluation of a new oral preparation of kanamycin, kanamycin 3-phenyl salicylate in the treatment of infections of the urinary tract. Antimicrob. Agents Chemother. 1962. In press. Google Scholar6. KIMBALLTURCKPETERSDORF HMRG: Unpublished observations. Google Scholar7. LINDEMEYERTURCKPETERSDORF RIMRG: An evaluation of a new antibiotic, actinospectacin, in infections of the urinary tract. Amer. J. Med. Sci.: 244: 478, 1962. CrossrefMedlineGoogle Scholar8. TURCKBROWDERLINDEMEYERBROWNANDERSONPETERSDORF MAARINKKNRG: Failure of prolonged treatment of chronic urinary tract infections with antibiotics. New Engl. J. Med.: 267: 999, 1962. CrossrefMedlineGoogle Scholar9. MCCABEJACKSONGRIEBLE WRGGHG: Treatment of chronic pyelonephritis. II. Short-term intravenous administration of single and multiple antibacterial agents: acidosis and toxic nephropathy from a preparation of intravenous nitrofurantoin. Arch. Intern. Med. 104: 710, 1959. 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New Engl. J. Med. 253: 969, 1955. CrossrefMedlineGoogle Scholar16. KUNINZACHAPAQUIN CMEAJ: Urinary tract infections in school children. I. Prevalence of bacteriuria and associated urologic findings. New Engl. J. Med. 266: 1287, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT I. LINDEMEYER, M.D.; MARVIN TURCK, M.D.; ROBERT G. PETERSDORF, M.D., F.A.C.P.Affiliations: Seattle, WashingtonFrom the Department of Medicine, University of Washington School of Medicine, and King County Hospital, Seattle, Washington.Supported by training grant 2E-146, United States Public Health Service, and in part by grants from Bristol Laboratories, the Upjohn Company, and E. I. du Pont de Nemours and Company.Dr. Lindemeyer is a trainee of the United States Public Health Service.Requests for reprints should be addressed to Robert G. Petersdorf, M.D., The King County Hospital System, 325 Ninth Avenue, Seattle 4, Washington. 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PETERSDORF, M.D., F.A.C.P.Treatment of PyelonephritisRECURRENT URINARY INFECTIONS IN GIRLS 1 February 1963Volume 58, Issue 2Page: 201-216KeywordsEscherichia coliEscherichia coli infectionsGastroenterology and hepatologyHospital medicineMedical servicesPathogensPyelonephritisUrinary tract infectionsUrine ePublished: 1 December 2008 Issue Published: 1 February 1963 Copyright & PermissionsCopyright ©, 1963, by The American College of PhysiciansPDF downloadLoading ...