tbuckley/cabot-search huggingface dataset:
Supranuclear Bulbar Palsy in Mitral Stenosis
Authors: K. W. G. Heathfield, E. C. O. Jewesbury
Journal: BMJ (1950)

<b>Aims:</b> To determine the prevalence of intraocular pressure (IOP) alterations following intravitreal injection of triamcinolone acetonide (IVTA) and to assess possible risk factors of IOP elevation in eyes receiving single and/or repeat injections. <b>Methods:</b> Retrospective, consecutive case series. 570 consecutive eyes of 536 patients who received a single IVTA injection (4 mg/0.1 ml) and a second set of 43 eyes of 40 patients who received a second injection. Retrospective review of all IVTA cases performed by three vitreoretinal surgeons over a 42 month period beginning in 2000. The main outcome measure was change in IOP defined as absolute value of IOP elevation (5 mm Hg or higher, 10 mm Hg or higher), and percentage of baseline (30% or higher increase from baseline IOP). <b>Results:</b> Of the 528 eyes receiving single injections, 281 (53.2%) had an IOP elevation; 267 eyes (50.6%) experienced an elevation of IOP of at least 30%, and 245 (45.8%) and 75 (14.2%) eyes had an increase of 5 mm Hg or 10 mm Hg or more, respectively. Baseline IOP greater than 16 mm Hg is a risk factor for post-injection IOP elevation. Of the 43 eyes which received a second injection, 28 (65.1%) experienced an increase in IOP of at least 30% of baseline. Filtering surgery was required in five (0.094%) of the single and one (2.3%) of repeat injection eyes. <b>Conclusions:</b> Elevated IOP after IVTA is common and patients should be monitored beyond 6 months post-injection. Patients with a baseline IOP more than 16 mm Hg or receiving a second injection should be carefully monitored for an elevated IOP.
Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking
Authors: A Sato, C Nishida, K Sato-Kusubata, M Ishihara, Y Tashiro, I Gritli, H Shimazu, S Munakata, H Yagita, K Okumura, Y Tsuda, Y Okada, A Tojo, H Nakauchi, S Takahashi, B Heissig, K Hattori
Journal: Leukemia (2014)
Benzocaine—an unsatisfactory indicator of topical local anaesthetic sensitization for the U.K.
Authors: M.H. BECK, ANN HOLDEN
Journal: British Journal of Dermatology (1988)

Three thousand consecutive patients undergoing patch tests were tested with a mix of benzocaine, amethocaine hydrochloride and cinchocaine hydrochloride. Eighty-four subjects (2.8%) were found to be allergic to this mix. Forty of these were patch tested with the constituents of the mix: 21 (52.5%) patients were sensitive to amethocaine hydrochloride or cinchocaine hydrochloride or both, but not to benzocaine. We recommend that a non-irritant 'caine mix' containing benzocaine, cinchocaine and amethocaine should be included in the standard patch test series for the U.K.
Portosystemic Collateral Circulation
Authors: Hung-Jen Hsieh, Kun-Han Lue, Chih-Hao K. Kao, Yung-Hsiang Hsu, Ming-Chien Liu, Pan-Fu Kao
Journal: Clinical Nuclear Medicine (2009)

A 42-year-old woman with advanced alcoholic liver cirrhosis was referred for a Tc-99m-labeled red blood cell (RBC) abdominal scan due to tarry stool passage. The Tc-99m RBC scan revealed a tangled linear radioactivity accumulation, extending from the right epigastric area to the right lower pelvic region. The integrated single-photon emission computed tomography/computed tomography (SPECT/CT) with 3D volume rendering imaging and CT bone segmentation display confirmed the portosystemic collateral circulation.
THE TREND OF MODERN PRESCRIPTION WRITING.
Authors: M. CLAYTON THRUSH
Journal: JAMA (1905)

The object of this paper is to show the trend of the physician in his prescribing at the present time. Five hundred prescriptions were carefully examined as they were received and filed in each of two of Philadelphia's best prescription stores, both of which are managed by able and energetic pharmacists, who have had collegiate training. Five hundred prescriptions were examined in each store in order to make proper comparisons, and also to give a more general report of the type of the modern prescription. These stores were so located that they received prescriptions from all the leading physicians of the city, and a large number of the prescriptions were from the pens of the professors and instructors on our medical school and hospital staffs, as well as a number from physicians in general practice, so that these prescriptions represent the type of prescription as written by our best practitioners
Intracystic Administration of Tc-99m Colloid Particles to Study Retention and Drainage in Lymphangioma of the Neck
Authors: ROBERT P. TAKES, RENATO A. VALDÉS OLMOS, FRANS J. M. HILGERS, CORNELIS A. HOEFNAGEL, PETER F. BRUNING
Journal: Clinical Nuclear Medicine (1994)

The particular use of lymphoscintigraphy to document retention and drainage in cystic lymphangioma of the neck is reported. Radionuclide examination using Tc-99m colliod particles, performed before sclerosing treatment with tetracycline in a patient with a large lymphangioma located in the neck, demonstrated a satisfactory tumor retention and slow outflow, enabling the administration of tetracycline without (risk of) organ toxicity. The treatment was successfully performed.
Determination of selenium in the environment and in biological material.
Authors: E M Bem
Journal: Environmental Health Perspectives (1981)

This paper reviews the following problems, sampling, decomposition procedures and most important analytical methods used for selenium determination, e.g., neutron activation analysis, atomic absorption spectrometry, gas-liquid chromatography, spectrophotometry, fluorimetry, and x-ray fluorescence. This review covers the literature mainly from 1975 to 1977.
Development of Occlusive Neointimal Lesions in Distal Pulmonary Arteries of Endothelin B Receptor–Deficient Rats
Authors: D. Dunbar Ivy, Ivan F. McMurtry, Kelley Colvin, Masatoshi Imamura, Masahiko Oka, Dong-Seok Lee, Sarah Gebb, Peter Lloyd Jones
Journal: Circulation (2005)

Human pulmonary arterial hypertension (PAH) is characterized by proliferation of vascular smooth muscle and, in its more severe form, by the development of occlusive neointimal lesions. However, few animal models of pulmonary neointimal proliferation exist, thereby limiting a complete understanding of the pathobiology of PAH. Recent studies of the endothelin (ET) system demonstrate that deficiency of the ET(B) receptor predisposes adult rats to acute and chronic hypoxic PAH, yet these animals fail to develop neointimal lesions. Herein, we determined and thereafter showed that exposure of ET(B) receptor-deficient rats to the endothelial toxin monocrotaline (MCT) leads to the development of neointimal lesions that share hallmarks of human PAH.The pulmonary hemodynamic and morphometric effects of 60 mg/kg MCT in control (MCT(+/+)) and ET(B) receptor-deficient (MCT(sl/sl)) rats at 6 weeks of age were assessed. MCT(sl/sl) rats developed more severe PAH, characterized by elevated pulmonary artery pressure, diminished cardiac output, and right ventricular hypertrophy. In MCT(sl/sl) rats, morphometric evaluation revealed the presence of neointimal lesions within small distal pulmonary arteries, increased medial wall thickness, and decreased arterial-to-alveolar ratio. In keeping with this, barium angiography revealed diminished distal pulmonary vasculature of MCT(sl/sl) rat lungs. Cells within neointimal lesions expressed smooth muscle and endothelial cell markers. Moreover, cells within neointimal lesions exhibited increased levels of proliferation and were located in a tissue microenvironment enriched with vascular endothelial growth factor, tenascin-C, and activated matrix metalloproteinase-9, factors already implicated in human PAH. Finally, assessment of steady state mRNA showed that whereas expression of ET(B) receptors was decreased in MCT(sl/sl) rat lungs, ET(A) receptor expression increased.Deficiency of the ET(B) receptor markedly accelerates the progression of PAH in rats treated with MCT and enhances the appearance of cellular and molecular markers associated with the pathobiology of PAH. Collectively, these results suggest an overall antiproliferative effect of the ET(B) receptor in pulmonary vascular homeostasis.
Genetic counseling: 'rationality' is in the eye of the beholder
Authors: W. Check
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Voluntary organ donation: autonomy ... tragedy
Authors: R. A. Kunin
Journal: JAMA (1993)

To the Editor.  —My son was still alive on life support when we said our goodbyes and left him 13 years ago. Neurology training had prepared me to accept the idea of brain death. My son's retinal veins showed air bubbles, indicating severe anoxia. He had been struck a single blow to the occiput and it was a mortal blow. He had two cardiac arrests before arrival at the hospital and was in a coma, unable to breathe on his own, when I arrived 4 hours later. I accepted the fact of his death. The neurosurgeon assured me he would be blind and a vegetable if he did survive, so I didn't push for electroencephalographic evidence.  I don't think that was a mistake. But I realize now, while reading Youngner and Arnold's article 1 13 years later, that my family just walked away from Tony in limbo, giving in to
Prophylaxis of Malaria
Authors: Craig Jay Brown
Journal: JAMA (1979)

<h3>To the Editor.—</h3> I want to add my support to the observation by B. H. Kean, MD (241:395, 1979) of a case of chloroquin-resistant falciparum malaria. From September 1977 through May 1978,I worked at the Baptist Medical Center in Nalerigu, Ghana, West Africa. Nalerigu is situated in the savannah lands of the Northern Region. Malaria is a year-round problem there, becoming epidemic during rainy seasons. The hospital has been serving that region for almost 20 years, treating 300 to 500 patients daily. At least one third of those require treatment for malaria, the standard adult therapy being chloroquin phosphate, 4 g administered during a three-day period, frequently with the addition of sulfadiazine. Despite this regimen, many patients are hospitalized with chronic malaria, which is confirmed by daily peripheral blood smears. Hospitalization is necessary to rule out failure to take medications properly. I had one case that proved resistant to a
Abstract P5-15-04: Clinical benefits of using nomogram for predicting positive resection margins in breast conserving surgery
Authors: E Lee, W Han, H-G Moon, J Kim, JW Lee, MK Kim, T-K Yoo, J Kim, D-Y Noh
Journal: Cancer Research (2013)

Abstract Achieving a clear resection margin in breast conserving surgery (BCS) is an important factor in tumor recurrence in breast cancer. To obtain clear resection margins and reduce re-excision rates, some surgeons obtain intraoperative assessments of the margins of excised specimens, using intraoperative frozen biopsy. But intraoperative frozen biopsy has several problems such as low sensitivity or longer operation time. We have previously reported a nomogram for prediction of positive resection margin by integrating preoperatively available clinical and pathologic information. The factors were the presence of microcalcification, mammographic density, tumor size discrepancy between magnetic resonance imaging and ultrasonography, and the presence of ductal carcinoma in situ or lobular carcinoma in needle biopsy specimens. We conducted a prospective trial to examine the accuracy and clinical benefits of the nomogram in 442 breast cancer patients (nomogram group) who underwent BCS between Dec 2011 and March 2013, and compared the clinical outcome with that of the 253 patients (control group) who underwent BCS between Jan 2011 and Oct 2011. For nomogram group, the intraoperative frozen section biopsy was omitted in patients with low nomogram scores. Applying our nomogram did not increase the rate of reoperation due to resection margin positivity when compared to the control group (6.56% vs. 4.25%, respectively, p = 0.22). In the nomogram group, the reoperation rate in patients with low nomogram score who did not undergo intraoperative frozen biopsy was 3.2%, and this is lower than the reoperation rate in the control group. Additionally, we experienced a significant reduction in operation time by 15 minutes when compared to the control group (p&amp;lt;0.001). In conclusion, our results show that out nomogram for predicting positive resection margin for patients who receive BCS can significantly reduce the operation time without increasing reoperation rate. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-15-04.
Clinical and Functional Histology for Medical Students
Authors: David Lagunoff
Journal: JAMA (1984)

When a reviewer and an author differ drastically on what is important, the least forgiving and forgivable review can be expected. This textbook of histology for medical students leaves out all the excitement of cell biology inherent in a modern introduction to human microscopic structure and, instead, substitutes a brief introduction to physiology and pathology. The limited index is also a problem; neither basal lamina nor basement membrane appears, neither alveolar pneumocyte nor any other term I could think of for the alveolar lining cells was present; but union, primary and secondary, was mentioned along with ultramicrotome and uvula. Nevertheless, pneumocytes are described in the section on lung, basement membrane appears in a diagram of a renal glomerulus, and basal lamina is identified in a drawing of thick skin, and probably elsewhere. The chapter on the respiratory system was 43 pages. Discourse on the lungs occupied a total of 104.5
Compulsory Health Insurance in Relation to Democratic Ideals
Authors: G. K. Higgins
Journal: JAMA (1963)

THE GREAT WORLD ISSUE of our time is the struggle between communism and democracy, between a political system that reposes all authority and power in the state, with denial of individual freedom and liberty, and a philosophy founded upon the freedom, liberty, and dignity of the individual. The great national issue of our time is the struggle between the claims of the welfare state and the claims of private enterprise. The solution of this issue must be sought by adhering to the ideals and tenets of democracy. In solving the problem, one must be mindful of an inherent danger to democracy—the tyranny of the majority. Lincoln's famous phrase, "government of the people, by the people, for the people," presumes that the majority will act in the best interests of the nation. The majority may, however, desire to oppress a minority, and precautions are needed as much against this form
Practising public health in primary care is easier said than done
Authors: R. Bhopal
Journal: BMJ (1995)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Practising public health in primary care is easier said than done Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Fatal Anaphylactic Shock from Procaine Penicillin
Authors: George A. Higgins, Thomas P. E. Rothchild
Journal: New England Journal of Medicine (1952)

REACTIONS following the administration of penicillin in its various forms are quite common, being reported in 5 to 10 per cent of all patients receiving this drug.1 The vast majority of these reactions are fortunately minor, rarely being severe enough to require discontinuance of the drug. The potentially antigenic properties of penicillin have been pointed out many times, and the occurrence of serious anaphylactic reactions was predicted by many early observers.2 Considering the wide use of penicillin in its various modes of administration, the number of anaphylactic reactions reported in the literature is astonishingly small (Table 1). Of the 2 . . .
The Significance of Angiogenesis in Malignant Pheochromocytomas
Authors: Patrick P. G. M. Rooijens, Ronald R. de Krijger, H. Jaap Bonjer, Frieda van der Ham, Alex L. Nigg, Hajo A. Bruining, Steven W. J. Lamberts, Erwin van der Harst
Journal: Endocrine Pathology (2004)
TWO AIDS IN MAKING BLOOD COUNTS
Authors: STERLING BUNNELL
Journal: JAMA (1910)

1. The practitioner is sometimes in need of an immediate white count when at the bedside and far from a microscope. Here is a quick, satisfactory and easy method by which it can be done in the patient's room and the result will be the same as if the counting were done through a regular microscope. <h3>Procedure.—</h3> Draw the blood into a pipette, dilute with acetic acid and place a drop in the Zeiss counting chamber in the usual way. Now hold the cover slip on the counting chamber with a rubber band. The chamber can then be held up to the light and the corpuscles will not slide across the field. The counting is done with a small pocket hand lens. A sixty-cent lens will do, but there are more powerful lenses on the market that are hardly larger than a pea and are even better. A single frosted
Autism Risk Across Generations
Authors: Emma M. Frans, Sven Sandin, Abraham Reichenberg, Niklas Långström, Paul Lichtenstein, John J. McGrath, Christina M. Hultman
Journal: JAMA Psychiatry (2013)

Advancing paternal age has been linked to autism.To further expand knowledge about the association between paternal age and autism by studying the effect of grandfathers' age on childhood autism.Population-based, multigenerational, case-control study.Nationwide multigeneration and patient registers in Sweden.We conducted a study of individuals born in Sweden since 1932. Parental age at birth was obtained for more than 90% of the cohort. Grandparental age at the time of birth of the parent was obtained for a smaller subset (5936 cases and 30 923 controls).International Classification of Diseases diagnosis of childhood autism in the patient registry.A statistically significant monotonic association was found between advancing grandpaternal age at the time of birth of the parent and risk of autism in grandchildren. Men who had fathered a daughter when they were 50 years or older were 1.79 times (95% CI, 1.35-2.37; P < .001) more likely to have a grandchild with autism, and men who had fathered a son when they were 50 years or older were 1.67 times (95% CI, 1.35-2.37; P < .001) more likely to have a grandchild with autism, compared with men who had fathered children when they were 20 to 24 years old, after controlling for birth year and sex of the child, age of the spouse, family history of psychiatric disorders, highest family educational level, and residential county. A statistically significant monotonic association was also found between advancing paternal age and risk of autism in the offspring. Sensitivity analyses indicated that these findings were not the result of bias due to missing data on grandparental age.Advanced grandparental age was associated with increased risk of autism, suggesting that risk of autism could develop over generations. The results are consistent with mutations and/or epigenetic alterations associated with advancing paternal age.
Natural history of left ventricular size and function after acute myocardial infarction. Assessment and prediction by echocardiographic endocardial surface mapping.
Authors: M H Picard, G T Wilkins, P A Ray, A E Weyman
Journal: Circulation (1990)

To investigate the natural history of regional dyssynergy and left ventricular size after myocardial infarction, 57 patients with a first Q wave myocardial infarction (18 anterior, 35 inferior, and four apical by echocardiography) were studied by two-dimensional echocardiography and compared with 30 control patients. Measurements from the echocardiograms were used to construct maps of the left ventricular endocardial surface from which the endocardial surface area index (ESAi) and the percent of the endocardial surface area involved by abnormal wall motion (%AWM) were calculated. The maps from entry and 3-month echocardiograms were used to classify patients based on changes in ESAi and abnormal wall motion. Two subgroups of patients were identified at entry--those with a normal ESAi (group 1, n = 50) and those with an increased ESAi (group 2, n = 7). Group 1 patients was subdivided at 3 months by changes occurring in ESAi (1A, 5% increase [n = 19]; 1B, no change [n = 23]; 1C, 5% decrease [n = 8]). The increase in ESAi (64.9 +/- 5.2 to 75.4 +/- 7.5 cm2/m2, p less than 0.0001) in group 1A was associated with global ventricular dilatation (n = 11) and clinically silent infarct extension (n = 8). Groups 1B and 1C were composed predominantly of patients with inferior infarctions, and all exhibited either no change or a significant decrease in infarct size (infarct regression). Group 2 patients demonstrated a continued increase in ESAi by 3 months (88.2 +/- 10.0 to 101.4 +/- 15.5 cm2/m2, p less than 0.007). This group comprised only patients with anterior infarctions, and all exhibited infarct expansion at the left ventricular apex. The changes in left ventricular size and functional infarct size are heterogeneous after acute myocardial infarction and relate to the initial endocardial surface area, infarct location, and functional infarct size.