tbuckley/cabot-search huggingface dataset:
New immune system genetic polymorphisms associated with moderate-to-severe plaque psoriasis: a case-control study
Authors: R. Prieto-Pérez, G. Solano-López, T. Cabaleiro, M. Román, D. Ochoa, M. Talegón, O. Baniandrés, J.L.L. Estebaranz, P. de la Cueva, E. Daudén, F. Abad-Santos
Journal: British Journal of Dermatology (2015)

R.P.P. and G.S.L. contributed equally to this manuscript. Dear Editor, Genes for factors such as interleukin‐23 receptor (IL‐23R), IL‐12B and tumour necrosis factor (TNF)‐α have been widely associated with psoriasis and related diseases [rheumatoid arthritis (RA), psoriatic arthritis (PsA) and Crohn disease (CD)].1 These genes are therapeutic targets to treat psoriasis. However, results with other candidate genes are controversial. Therefore, large‐scale studies are needed to verify the genetic factors that trigger psoriasis. We evaluated the possible association between 192 single‐nucleotide polymorphisms (SNPs) and moderate‐to‐severe chronic plaque psoriasis. This approach may help us to find new targets for safer and more effective drugs. We recruited 197 healthy volunteers without a personal or family history of psoriasis, and 198 patients with moderate‐to‐severe plaque psoriasis between 16 October 2007 and 17 December 2012, in four hospitals in Madrid, Spain. All patients were white. The protocol fulfilled Spanish law on biomedical research. DNA was obtained from peripheral blood samples (MagNA Pure® System; Roche, Pleasanton, CA, U.S.A.). All samples were sent to the Human Genotyping Unit (CEGEN, Madrid, Spain), except two samples that had insufficient volume, to genotype 192 SNPs (VeraCode genotyping platform; Illumina, San Diego, CA, U.S.A.). The SNPs were preselected based on reports of psoriasis and other autoimmune diseases (RA, PsA and CD; 449 articles). We finally selected SNPs based on minor allele frequency ≥ 0·05, and on the results of studies performed in white patients with psoriasis (Table S1; see Supporting Information).
George L. Fite, MD: A Decade at JAMA
Authors: Phil Gunby
Journal: JAMA (1993)

GEORGE LIDDLE FITE, MD, a senior editor of<i>JAMA</i>from early 1965 until late 1974 and a developer of the Fite-Faraco stain for demonstrating lepra bacilli in paraffin sections, is dead at the age of 89 years. Fite, who last appeared on<i>JAMA</i>'s masthead in the October 28,1974, issue, was known amongThe Journal's staff for his ability to summarize even the most complex manuscripts—and his opinion of them—in a few pithy sentences. He was involved when<i>JAMA</i>replaced its front-cover table of contents with art covers and also presided for a time over the Letters pages. Born in Austin, Tex, February 20, 1904, he grew up in Indiana and New Jersey, graduating from Haverford (Pa) College in 1924 and Harvard Medical School, Boston, Mass, in 1928. He was an instructor at The Johns Hopkins University School of Medicine, Baltimore, Md, from 1929 until 1932; research assistant at
Outbreak of<i>Vibrio parahaemolyticus</i>Gastroenteritis Associated with Alaskan Oysters
Authors: Joseph B. McLaughlin, Angelo DePaola, Cheryl A. Bopp, Karen A. Martinek, Nancy P. Napolilli, Christine G. Allison, Shelley L. Murray, Eric C. Thompson, Michele M. Bird, John P. Middaugh
Journal: New England Journal of Medicine (2005)

Vibrio parahaemolyticus, the leading cause of seafood-associated gastroenteritis in the United States, typically is associated with the consumption of raw oysters gathered from warm-water estuaries. We describe a recognized outbreak of V. parahaemolyticus infection associated with the consumption of seafood from Alaska.After we received reports of the occurrence of gastroenteritis on a cruise ship, we conducted a retrospective cohort study among passengers, as well as active surveillance throughout Alaska to identify additional cases, and an environmental study to identify sources of V. parahaemolyticus and contributors to the outbreak.Of 189 passengers, 132 (70 percent) were interviewed; 22 of the interviewees (17 percent) met our case definition of gastroenteritis. In our multiple logistic-regression analysis, consumption of raw oysters was the only significant predictor of illness; the attack rate among people who consumed oysters was 29 percent. Active surveillance identified a total of 62 patients with gastroenteritis. V. parahaemolyticus serotype O6:K18 was isolated from the majority of patients tested and from environmental samples of oysters. Patterns on pulsed-field gel electrophoresis were highly related across clinical and oyster isolates. All oysters associated with the outbreak were harvested when mean daily water temperatures exceeded 15.0 degrees C (the theorized threshold for the risk of V. parahaemolyticus illness from the consumption of raw oysters). Since 1997, mean water temperatures in July and August at the implicated oyster farm increased 0.21 degrees C per year (P<0.001 by linear regression); 2004 was the only year during which mean daily temperatures in July and August at the shellfish farm did not drop below 15.0 degrees C.This investigation extends by 1000 km the northernmost documented source of oysters that caused illness due to V. parahaemolyticus. Rising temperatures of ocean water seem to have contributed to one of the largest known outbreaks of V. parahaemolyticus in the United States.
Potassium channel openers accelerate epidermal barrier recovery
Authors: M. Denda, M. Tsutsumi, K. Inoue, D. Crumrine, K.R. Feingold, P.M. Elias
Journal: British Journal of Dermatology (2007)

Maintenance of a competent permeability barrier in the face of external and internal stressors requires signals between the stratum corneum interface and the metabolic machinery in the underlying nucleated layers. For example, reductions in the ion gradients for Ca2+ after acute barrier disruption stimulate lamellar body (LB) secretion, a response required to restore barrier homeostasis. Although alterations in external K+ levels also regulate barrier recovery after acute insults, the mechanisms whereby K+ regulates barrier function remain unknown.To evaluate effects of regulators of K+ channels on barrier homeostasis in hairless mice.We tested a number of chemically different drugs that alter intracellular K+ levels. Results Single applications of either K+ channel openers (i.e. 1-EBIO, minoxidil, diazoxide) or the K+ ionophore, valinomycin, accelerated barrier recovery after acute insults to murine skin, paralleled by a reduction in intracellular K+ levels in cultured human keratinocytes. In contrast, applications of K+ channel blockers (i.e. gilbenclamide, dequalinium) delayed barrier recovery. Alterations in intracellular K+ regulated barrier homeostasis by either stimulating (reduced K+) or inhibiting (elevated K+) LB secretion. Finally, development of epidermal hyperplasia, a downstream consequence of barrier disruption, was also inhibited by agents that reduce intracellular K+ levels.These results demonstrate that changes in K+ levels that can be presumed to occur after barrier disruption signal metabolic responses, i.e. LB secretion, which accelerates normalization of barrier function.
Effects of dexamethasone on the growth of cultured rabbit articular chondrocytes:relation with the nuclear glucocorticoid-receptor complex.
Authors: B Hainque, J Dominice, P Jaffray, X Ronot, M Adolphe
Journal: Annals of the Rheumatic Diseases (1987)

This study reports that dexamethasone at a high dose (10(-4) mol/l) induced slowing of the in vitro proliferation of rabbit articular chondrocytes in both monolayer and clonal culture. This effect is consistent with an inhibition of DNA and RNA synthesis and was characterised by an accumulation of cells in the G0G1 phase of the cell cycle, as shown by flow cytometric analysis. Therefore we determined the extent of nuclear localisation of dexamethasone-receptor complexes. The results showed a discrepancy between 50% growth inhibitory dose (10(-4) mol/l) and the apparent affinity, KD (1.4 (SD 0.2) X 10(-9) mol/l). Thus the growth inhibition of rabbit articular chondrocytes by dexamethasone did not seem to be related exclusively to an interaction with the glucocorticoid-receptor complexes.
Comparative Toxicity of Size-Fractionated Airborne Particulate Matter Collected at Different Distances from an Urban Highway
Authors: Seung-Hyun Cho, Haiyan Tong, John K. McGee, Richard W. Baldauf, Q. Todd Krantz, M. Ian Gilmour
Journal: Environmental Health Perspectives (2009)

BackgroundEpidemiologic studies have reported an association between proximity to highway traffic and increased cardiopulmonary illnesses.ObjectivesWe investigated the effect of size-fractionated particulate matter (PM), obtained at different distances from a highway, on acute cardiopulmonary toxicity in mice.MethodsWe collected PM for 2 weeks in July–August 2006 using a three-stage (ultrafine, < 0.1 μm; fine, 0.1–2.5 μm; coarse, 2.5–10 μm) high-volume impactor at distances of 20 m [near road (NR)] and 275 m [far road (FR)] from an interstate highway in Raleigh, North Carolina. Samples were extracted in methanol, dried, diluted in saline, and then analyzed for chemical constituents. Female CD-1 mice received either 25 or 100 μg of each size fraction via oropharyngeal aspiration. At 4 and 18 hr postexposure, mice were assessed for pulmonary responsiveness to inhaled methacholine, biomarkers of lung injury and inflammation; ex vivo cardiac pathophysiology was assessed at 18 hr only.ResultsOverall chemical composition between NR and FR PM was similar, although NR samples comprised larger amounts of PM, endotoxin, and certain metals than did the FR samples. Each PM size fraction showed differences in ratios of major chemical classes. Both NR and FR coarse PM produced significant pulmonary inflammation irrespective of distance, whereas both NR and FR ultrafine PM induced cardiac ischemia–reperfusion injury.ConclusionsOn a comparative mass basis, the coarse and ultrafine PM affected the lung and heart, respectively. We observed no significant differences in the overall toxicity end points and chemical makeup between the NR and FR PM. The results suggest that PM of different size-specific chemistry might be associated with different toxicologic mechanisms in cardiac and pulmonary tissues.
A NOTE ON THE CHEMICAL DIAGNOSIS OF HYPERNEPHROMAS (SUPRARENAL TUMORS) OF THE KIDNEY.
Authors: ALFRED C. CROFTAN
Journal: JAMA (1903)

In two recent publications<sup>1</sup>I have shown that a watery extract of fresh suprarenal glands possesses the following properties: Injected into the body of a dog or a rabbit it produces glycosuria (see also Blum's, Zuelzer's and Herter's recent publications). It possesses the power of converting starch into dextrose and maltose and this power of the extract is lost on boiling. It causes the blue color produced by iodin in a starch solution to disappear. I am indebted to Dr. A. O. J. Kelly of Philadelphia, whose work on hypernephromas is well known, for the suggestion that possibly hypernephromas possessed properties similar to those shown to be possessed by the suprarenals themselves. It seemed possible that an investigation of this question might lead to an additional and important means of differentiating hypernephromas from tumors derived from proper renal structures. Inasmuch as it was thought that conclusive evidence
Author's reply to Backman and Bakhai
Authors: M. Pirmohamed
Journal: BMJ (2013)

Backman and Bakhai question the clinical importance of drug-grapefruit juice interactions, focusing on statins.1 2 The risk of statin related myopathy is concentration dependent, but not everybody with the same (high) plasma statin concentration develops muscle injury (because susceptibility varies).3 However, anecdotal evidence or the sparseness of case reports cannot prove there is no risk. Drug …
Transcriptional inhibition of progressive renal disease by gene silencing pyrrole–imidazole polyamide targeting of the transforming growth factor-β1 promoter
Authors: Hiroyuki Matsuda, Noboru Fukuda, Takahiro Ueno, Mayumi Katakawa, Xiaofei Wang, Takayoshi Watanabe, Sei-Ichi Matsui, Takahiko Aoyama, Kosuke Saito, Toshikazu Bando, Yoshiaki Matsumoto, Hiroaki Nagase, Koichi Matsumoto, Hiroshi Sugiyama
Journal: Kidney International (2010)
Angiotensin-Converting Enzyme Inhibitor Therapy Affects Left Ventricular Mass in Patients With Ejection Fraction &gt;40% After Acute Myocardial Infarction
Authors: David B. Johnson, Robert E. Foster, Francesco Barilla, Gerald G. Blackwell, Maryann Roney, Alfred W.H. Stanley, Kathy Kirk, Roger A. Orr, Rob J. van der Geest, Johan H.C. Reiber, Louis J. Dell’Italia
Journal: Journal of the American College of Cardiology (1997)
Combined Sellar Fibrosarcoma and Prolactinoma with Neuronal Metaplasia: Report of a Case Unassociated with Radiotherapy
Authors: Mario Moro, Caterina Giannini, Bernd W. Scheithauer, Ricardo V. Lloyd, Paul Restall, Carl Eagleton, Andrew J. Law, Kalman Kovacs
Journal: Endocrine Pathology (2004)
Atrial natriuretic factor inhibits the hypertension induced by chronic infusion of norepinephrine in conscious rats.
Authors: M Yasujima, K Abe, M Kohzuki, M Tanno, Y Kasai, M Sato, K Omata, K Kudo, K Tsunoda, K Takeuchi
Journal: Circulation Research (1985)

To assess the physiological role of atrial natriuretic factors in the regulation of blood pressure and sodium-water excretion, we studied the chronic effects of continuous infusion of a synthetic atrial natriuretic factor of 25 amino acids for up to 3 days on systolic blood pressure, urine volume, and urinary excretion of sodium, prostaglandin E2 and kallikrein in conscious rats, and also evaluated the antihypertensive effect of this substance in rats with hypertension caused by chronic infusion of norepinephrine. Continuous infusion of atrial natriuretic factor (150 micrograms/kg per day) into the jugular vein via osmotic minipumps did not induce any changes in systolic blood pressure, urine volume, and urinary excretion of sodium, prostaglandin E2, and kallikrein for up to 3 days, compared with those in vehicle-infused rats. When the same dose of atrial natriuretic factor was administered simultaneously with 1.8 mg/kg per day of norepinephrine infused intraperitoneally by osmotic minipumps, the systolic blood pressure of conscious rats rose on day 1 to only 127.3 +/- 6.3 mm Hg compared with the rise to 146.3 +/- 1.6 mm Hg when norepinephrine alone was infused (P less than 0.05). The antihypertensive effect of atrial natriuretic factor was sustained for 3 days in rats infused with norepinephrine. The administration of atrial natriuretic factor to rats made hypertensive by 3 days of infusion with norepinephrine alone returned the blood pressure to control levels, and the antihypertensive effect was sustained throughout the experimental period lasting for 3 days.(ABSTRACT TRUNCATED AT 250 WORDS)
A Novel Telomere Structure in a Human Alternative Lengthening of Telomeres Cell Line
Authors: Robert A. Marciniak, David Cavazos, Richard Montellano, Qijun Chen, Leonard Guarente, F. Brad Johnson
Journal: Cancer Research (2005)

Abstract Cancer cells require mechanisms to maintain telomeres. Most use telomerase, but 5% to 20% of tumors use alternative lengthening of telomeres (ALT), a telomerase-independent mechanism that seems to depend on recombination. ALT is characterized by amplification of telomere TTAGGG repeats to lengths beyond 50 kb, by elevated rates of telomere recombination, and by nuclear structures called ALT-associated promyelocytic leukemia bodies. In Saccharomyces cerevisiae, survivors of telomerase inactivation also use recombination to maintain telomeres. There are two types of survivors, which differ in telomere structure. The first possesses telomere repeats and the Y′ subtelomeric element amplified together as a tandem array at chromosome termini (type I), and the other possesses amplification of telomeric repeats alone (type II), similar to previously described human ALT cells. Here, we describe the first human ALT cell line having “tandem array” telomeres with a structure similar to that of type I yeast survivors. The chromosome termini consist of a repeat unit containing ∼2.5 kb of SV40 DNA and a variable amount of TTAGGG sequence repeated in tandem an average of 10 to 20 times. Similar to previously described ALT cells, they show evidence of telomere recombination, but unlike standard ALT cells, they lack ALT-associated promyelocytic leukemia bodies and their telomeres are transcribed. These findings have implications for the pathogenesis and diagnosis of cancer.
Oxidized Low-Density Lipoproteins Inhibit Endothelial Cell Proliferation by Suppressing Basic Fibroblast Growth Factor Expression
Authors: Chu-Huang Chen, Wei Jiang, David P. Via, Sherry Luo, Tz-Rung Li, Yuan-Teh Lee, Philip D. Henry
Journal: Circulation (2000)

Background —Hyperlipidemia inhibits proliferation of endothelial cells (ECs) in culture and angiogenesis in vivo and in arterial explants. Elucidation of the mechanisms may suggest novel therapies against atherosclerosis. Methods and Results —Basic fibroblast growth factor (bFGF) expression and mitogenic effects were assessed in bovine aortic ECs incubated with oxidized LDL (ox-LDL). Compared with native LDL and lipoprotein-free controls, ox-LDL reduced bFGF mRNA levels in a time- and concentration-dependent manner, 100 μg/mL producing a maximum reduction of 40% to 50% within 24 to 48 hours. There were commensurate reductions in intracellular and extracellular bFGF concentrations, DNA and total RNA syntheses, and cell replication. FGF receptor 1 and β-actin mRNA levels were unchanged. Ox-LDL accelerated bFGF mRNA degradation in actinomycin D–treated cells. However, inhibition of bFGF expression by ox-LDL was attenuated by cyclohexamide, indicating a requirement for continuous new protein synthesis for posttranscriptional destabilization. Reduced syntheses of DNA and total RNA were completely restored by bFGF but not by vascular endothelial growth factor. Inhibition of total RNA synthesis achieved by exposing cells to a bFGF-neutralizing antibody was similar in magnitude to that induced by ox-LDL. Conclusions —Cytotoxic effects of ox-LDL on ECs are attributable in part to suppression of bFGF expression.
Grading of Prostate Cancer
Authors: John L. Zeller
Journal: JAMA (2007)

Grading of Prostate CancerP rostate cancer (an abnormal, uncontrolled growth of cells originating in the prostate gland) is the most common cancer among American men.The October 3, 2007, issue of JAMA includes an article on the importance of grading prostate cancer and the implications regarding therapy options and possible recurrence.
THE ACTION SPECTRUM OF 8-METHOXYPSORALEN.
Authors: R. KOOIJ, A. T. NESER, F. P. SCOTT
Journal: British Journal of Dermatology (1963)

Journal Article THE ACTION SPECTRUM OF 8‐METHOXYPSORALEN. Get access R. KOOIJ, M.D., R. KOOIJ, M.D. Department of Dermatology, University of Cape Town, Cape Town Search for other works by this author on: Oxford Academic Google Scholar A. T. NESER, B.Sc, M.B., Ch.B., A. T. NESER, B.Sc, M.B., Ch.B. South African Institute for Medical Research, Bloemfontein Search for other works by this author on: Oxford Academic Google Scholar F. P. SCOTT, M.Med.(Derm.) F. P. SCOTT, M.Med.(Derm.) Dermatologist, National Hospital, Bloemfontein Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 75, Issue 6, 1 June 1963, Pages 245–248, https://doi.org/10.1111/j.1365-2133.1963.tb13558.x Published: 01 June 1963
THE EPIDEMIOLOGY OF A RABBIT RESPIRATORY INFECTION
Authors: Leslie T. Webster
Journal: The Journal of Experimental Medicine (1924)

Rabbits were bred at The Rockefeller Institute with special relation to protection from exposure to Bacterium lepisepticum. These healthy rabbits were then submitted to intranasal instillation of a given dose of cultures of Bacterium lepisepticum. The results of the inoculation were various according to the natural degree of resistance of the individual animals. The following graded effects could be distinguished: Some of the animals became (1) short time carriers of Bacterium lepisepticum; others (2) long time carriers of the same organism; some developed (3) local nasal infection (snuffles) of short duration; others (4) local nasal infection (snuffles) of long duration; while yet others had (5) snuffles, followed by pneumonia and signs of general infection after a few weeks; and finally there were instances of (6) local nasal discharge attended by general infection and pneumonia after a few days. The effects produced in any given healthy stock depend also upon the degree of virulence of Bacterium lepisepticum of which great differences exist among the same and different strains.
Increased Serum Levels of a Parathyroid Hormone-like Protein in Malignancy-Associated Hypercalcemia
Authors: Amer A. Budayr
Journal: Annals of Internal Medicine (1989)

Study Objective: To measure the serum levels of a newly described parathyroid hormone-like protein (PLP), which was isolated from malignant tumors associated with hypercalcemia, and determine whether PLP is a humoral factor in malignancy-associated hypercalcemia. Design: A cross-sectional study of serum levels of PLP using a newly developed radioimmunoassay. Setting: A university-affiliated Veterans Administration hospital in San Francisco, California, a University hospital in Hong Kong, and a private hospital in Danville, Pennsylvania. Patients: Patients with hypercalcemia (calcium > 2.65 mmol/L) and a diagnosis of malignancy were studied. Control groups included normocalcemic patients with malignancy, patients with hyperparathyroidism, and normal subjects. Measurements and Main Results: Serum immunoreactive PLP (iPLP) levels in normal subjects were less than 2.5 pmol eq/L (10 pg/mL), and 68% of subjects had undetectable levels. The serum concentration of iPLP was normal in 15 of 16 hypercalcemic patients with hyperparathyroidism. Serum iPLP was increased ( > 2.5 pmol eq/L) in 36 of 65 (55%) patients with malignancy-associated hypercalcemia, with a mean value of 6.1 ± 0.9 pmol eq/L (24 pg/mL). In a subgroup of patients with solid tumors, serum iPLP was increased in 30 (71%) of 42 hypercalcemic patients, with a mean value of 6.5 0± 0.9 pmol eq/L. Serum iPLP was elevated in only 3 of 23 normocalcemic patients with cancer. In patients with solid malignancies (n = 59), levels of iPLP were positively correlated with the total serum calcium (r = 0.43, P < 0.01). Conclusions: The data indicate a relation between the serum concentration of iPLP and the presence of hypercalcemia in solid malignancies. The results support a role for PLP as a humoral mediator of hypercalcemia in most patients with solid tumors. Measurement of iPLP should be useful in the differential diagnosis of hypercalcemia.