tbuckley/cabot-search huggingface dataset:
Preterminal Morbidity in Renal Transplant Recipients—The Major Events Leading to Their Demise.
Authors: Mark S. Kramer
Journal: Annals of Internal Medicine (1969)

s1 May 1969Preterminal Morbidity in Renal Transplant Recipients—The Major Events Leading to Their Demise.Mark S. Kramer, M.D., Satoru Nakamoto, M.D.Mark S. Kramer, M.D.Search for more papers by this author, Satoru Nakamoto, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1094_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo study the clinical course of a renal transplant recipient more fully and to elucidate the major clinical events that occasionally lead to death, preterminal morbidity was evaluated. One hundred eighty-two transplants in 156 patients, transplanted over a 51½-year period, were reviewed regarding the immunologic rejection phenomenon and infectious, pulmonary, central nervous system (CNS), hematopoietic, and gastrointestinal complications, and combinations of these processes. In this series, 93 patients died. Sixty patients exhibited the transplant rejection reaction either by itself or more commonly in combination with some other process. Pneumonia either by itself or in combination with gastrointestinal hemorrhage and bacteremia... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1094-1095KeywordsBacteremiaCentral nervous systemGastrointestinal hemorrhageGastrointestinal infectionsMorbidityPneumoniaPulmonary diseasesRenal transplantationTransplant rejection Issue Published: 1 May 1969 PDF downloadLoading ...
A National Agenda for Women's Health
Authors: James O. Mason
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies May Not Provide Clear View of Antipsychotics
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cephaloglycin. Clinical and laboratory experience with an orally administered cephalosporin
Authors: W. D. Johnson
Journal: JAMA (1968)

Cephaloglycin was evaluated in vitro and in the treatment of urinary tract infection. Over 90% of strains of Escherichia coli, Proteus mirabilis, and Klebsiella-Aerobacter were inhibited by concentrations of cephaloglycin achieved in the urine of patients receiving cephaloglycin as therapy for urinary tract infections. Peak serum concentrations of cephaloglycin inhibited all strains of group A streptococci and Diplococcus pneumoniae and some strains of Staphylococcus aureus, E coli, and p mirabilis. Twenty-three patients with urinary tract infection were treated with cephaloglycin. Most of the patients had structural abnormalities or chronic infection of the urinary tract. All patients were free of bacteriuria during therapy and 11 patients (48%) were abacteriuric one month after discontinuation of therapy. Diarrhea and eosinophilia were the only side effects noted and did not constitute a major problem.
622 Efficacy and safety of peginterferon alpha-2a (40KD) [PEG] plus ribavirin [RBV] 1000/1200 mg/d in genotype 1 patients with chronic hepatitis C and ‘normal’ ALT levels
Authors: E. Zehnter, S. Mauss, C. John, R. Heyne, B. Möller, T. Lutz, B. Bokemeyer, R. Kihn, G. Moog, U. Alshuth, D. Hüppe
Journal: Journal of Hepatology (2006)
Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease
Authors: Masaomi Iyo, Hiroki Namba, Kiyoshi Fukushi, Hitoshi Shinotoh, Shinichiro Nagatsuka, Tetsuya Suhara, Yasuhiko Sudo, Kazutoshi Suzuki, Toshiaki Irie
Journal: The Lancet (1997)
Distribution of Intact Peanut Protein and Digestion-Resistant Ara h 2 Peptide in Human Serum and Saliva
Authors: J.L. Baumert, R.K. Bush, M.B. Levy, S.J. Koppelman, J.A. Nordlee, S.L. Hefle, S.L. Taylor
Journal: Journal of Allergy and Clinical Immunology (2009)
Electronic Cancer Munchausen Syndrome
Authors: Venus Hadeed
Journal: Annals of Internal Medicine (1998)

Letters1 July 1998Electronic Cancer Munchausen SyndromeVenus Hadeed, MD, Donald L. Trump, MD, and Carolyn Mies, MDVenus Hadeed, MDUniversity of Pittsburgh School of Medicine; Pittsburgh, PA 15213Jackson Memorial Hospital; Miami, FL 33136, Donald L. Trump, MDUniversity of Pittsburgh School of Medicine; Pittsburgh, PA 15213Jackson Memorial Hospital; Miami, FL 33136, and Carolyn Mies, MDUniversity of Pittsburgh School of Medicine; Pittsburgh, PA 15213Jackson Memorial Hospital; Miami, FL 33136Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-1-199807010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We present a case in which electronic records were appropriated to create factitious reports.In 1995, a 32-year-old man sought experimental therapy for metastatic adenocarcinoma of the urinary bladder. He reported a history of adenocarcinoma of the bladder that had recurred despite irradiation, chemotherapy plus autologous bone marrow transplantation, and investigational chemotherapy. The patient brought copies of his records, including diagnostic surgical pathology and cytology reports and several radiology reports. The physical examination was normal.We contacted the pathologist at the hospital where most of the patient's care was reported to have been given. She discovered discrepancies ...References1. D'Andrea VJ. Cancer pathomimicry: a report of three cases. J Clin Psychiatry. 1978; 39:233-40. Google Scholar2. Miller F, Weiden P, Sacks M, Wozniak J. Two cases of factitious acquired immune deficiency syndrome. Am J Psychiatry. 1986; 143:1483. Google Scholar3. Cooke MW, Grace RH. The modern Munchausen syndrome. J R Soc Med. 1990; 83:272-3. Google Scholar4. Pendlebury SC. Malignant Munchausen. Med J Austral. 1991; 155:849-50. Google Scholar5. Bruns AD, Fishkin PA, Johnson EA, Lee VT. Munchausen vs syndrome and cancer. J Surg Oncol. 1994; 56:136-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Venus Hadeed, MD; Donald L. Trump, MD; Carolyn Mies, MDAffiliations: University of Pittsburgh School of Medicine; Pittsburgh, PA 15213Jackson Memorial Hospital; Miami, FL 33136 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFactitious disorder (Munchausen's syndrome) in oncology: case report and literature reviewLes pathologies factices en oncologieFactitious disorders and malingering: challenges for clinical assessment and managementFactitious Disorders: the Baron's legacyElectronic Patient–Physician CommunicationH.C. George Wong, MD, FRCPC 1 July 1998Volume 129, Issue 1Page: 73KeywordsAdenocarcinomaBladderCancer treatmentChemotherapyElectrode recordingPathologistsPatientsSpineSurgerySurgical pathology ePublished: 15 August 2000 Issue Published: 1 July 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Shadows bordering the lung on radiographs of normal and obese persons
Authors: M. C. Gluck, H. L. Twigg, M. F. Ball, P. G. Rhodes
Journal: Thorax (1972)

The thickness of the shadows that accompany ribs or border the lungs on the chest postero-anterior radiographs of 22 obese patients and 22 normal-weight subjects was measured, when present, at several rib levels. A similar measurement was made of accompanying rib shadows on chest postero-anterior radiographs of eight obese patients after weight reduction. Statistical analysis showed that there were significantly thicker soft tissue shadows adjacent to the ribs of obese subjects compared to normal-weight persons and of obese subjects before as compared to after weight reduction. Such shadows are more frequent and are seen at more rib levels of the obese. In addition, the following pertinent features are discussed: the mechanism by which soft tissue projects a radiographic shadow, the factors affecting its appearance, and the significance of such shadows as a variant of the normal chest radiograph and not as a manifestation of pathology.
Points from letters: Haslemere festival
Authors: J A Chalmers
Journal: BMJ (1975)

October, p 25) is not alone.At the inception of the NHS in 1948 I was an assistant in general practice and lived above the surgery in a traffic-congested area.At that time I managed my rounds quite easily on a bicycle.Unfortunately both your clientele and your colleagues come to regard you as an outsider, which adds to your emotional burden.The car becomes your
Renal failure after topical use of NSAIDs
Authors: A H N Fernando, R M Temple, S Thomas, H A Lee
Journal: BMJ (1994)

EDITOR, - We wish to amplify the case reports of C A O' Callaghan and colleagues1 by reporting on a patient who developed acute renal failure twice: once after taking ibuprofen orally and once after topical administration of the drug.

A 76 year old man was admitted with acute anuric renal failure five days after taking four tablets of ibuprofen for a muscle strain. In the 48 …
Bilateral posterior dislocation of shoulders.
Authors: A. M. Campbell
Journal: BMJ (1969)

MEDBRITCISHOUNA is so narrow ?(Maximum in the one= £1,005 and in the other=F£1,172.)The career prospects in radiography are shown to be poor indeed when comparison is made with those of physiotherapists.In 1958 the scales were: physiotherapists top grade-£750 to £960; superintendent radiographer-£810 to £920.(Maximum £40 less for superintendent radiographer.)In 1969 the scales were: physiotherapists top grade-1,570 to £2,050; superinten- dent radiographer III-£1,286 to £1,668.(The £40 less for the superintendent radio- grapher in 1958 has now grown to £382 on the final increment.)What inducement really is there to seniors to stay in radiography-particularly the married men, whose skills are so often sought by industry ?These figures speak for them- selves and illustrate clearly the point which
Cheese is bad for your health
Authors: D. Reilly
Journal: BMJ (1995)

There was a lot of talk about cheese during a recent visit to New Zealand and certainly the variety available had greatly improved. But it was not until I had received one or two funny looks from my medical friends that I found that they were referring to CHEs, or crown health enterprises, which are equivalent to trust hospitals in Britain. It was interesting to see that all the ideological claptrap familiar to us has also infected New Zealand: people who are not doctors said that the health service had been run for far too long for the benefit of doctors and nurses and not for patients. It seems unlikely, however, that the reforms will have quite the same destructive effect. There is more geographical isolation in New Zealand, so hospitals will not savage each other to death in the same way. In addition, hospitals are starting to specialise instead of trying to do everything in order to compete in the new market.

There was the same …
Relation of low diastolic blood pressure to coronary heart disease death in presence of myocardial infarction: the Framingham Study.
Authors: R B D'Agostino, A J Belanger, W B Kannel, J M Cruickshank
Journal: BMJ (1991)

To examine the hypothesis that a J curve relation between blood pressure and death from coronary heart disease is confined to high risk subjects with myocardial infarction.Cohort longitudinal epidemiological study with biennial examinations since 1950.Framingham, Massachusetts, USA.5209 subjects in the Framingham study cohort followed up by a person examination approach.Coronary heart disease deaths and non-cardiovascular disease deaths in men and women with or without myocardial infarction relative to blood pressure.Among subjects without myocardial infarction non-cardiovascular disease deaths were twice to three times as common as coronary heart disease deaths. Furthermore, there was no significant relation between non-cardiovascular disease death and diastolic or systolic blood pressure. Also coronary heart disease deaths were linearly related to diastolic and systolic blood pressures. Among high risk patients (that is, people with myocardial infarction but free of congestive heart failure) death from coronary heart disease was more common than non-cardiovascular disease death. There was a significant U shaped relation between coronary heart disease death and diastolic blood pressure. Although there was an apparent U shaped relation between coronary heart disease death and systolic blood pressure, it did not attain statistical significance when controlling for age and change in systolic blood pressure from the pre-myocardial infarction level. None of the above conclusions changed when adjustments were made for risk factors such as serum cholesterol concentration, antihypertensive treatment, and left ventricular function. The U shaped relation between diastolic blood pressure and high risk subjects existed for both those given antihypertensive treatment and those not.These data suggest that an age and sex independent U curve relation exists for diastolic blood pressure and coronary heart disease deaths in patients with myocardial infarction but not for low risk subjects without myocardial infarction. The relation seems to be independent of left ventricular function and antihypertensive treatment.
Abstract 3434: EphB3 mediates kinase-dependent suppression of non-small cell lung cancer metastasis
Authors: Guo Li, Xiao-dan Ji, Dong Xie
Journal: Cancer Research (2012)

Abstract Eph family is one of the largest subfamily of receptor tyrosine kinases. Their important but controversial roles in cancer development have drawn growing attentions in recent years. We have recently reported that EphB3 acts as a tumor promoter in human non-small-cell lung cancer (NSCLC) independent of its kinase activity (Cancer Research. 71(3):1156, 2011). In the present study, we find that despite overexpression of EphB3 in NSCLC, the expression of its cognate ligands, ephrin-B1 and ephrin-B2, is significantly down-regulated, leading to reduced tyrosine phosphorylation of EphB3. Activation of EphB3 kinase with either ligand stimulation or genomic engineering (Y608/614E) in EphB3-overexpressing NSCLC cells inhibits cell migratory capability in vitro as well as in vivo metastatic seeding. Furthermore, we have identified a novel EphB3-binding protein, the receptor for activated C-kinase 1 (RACK1), which mediates the assembly of a ternary signal complex comprising protein phosphatase 2A (PP2A), Akt and itself in response to EphB3 activation, leading to reduced Akt phosphorylation and subsequent inhibition of cell migration. Our study reveals a novel tumor-suppressing signaling pathway associated with kinase-activated EphB3 in NSCLC, and provides a potential therapeutic strategy by activating EphB3 signaling, thus inhibiting tumor metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3434. doi:1538-7445.AM2012-3434
Tightening Red-Cell Membranes
Authors: Harry S. Jacob
Journal: New England Journal of Medicine (1976)

The lipid bilayer model of membrane structure proposed by Davson and Danielli1 remains an attractive, but imperfect, description of erythrocyte membrane conformation. Important modifications have become necessary in this model, which depicts: (a) hydrophobic lipid components (acyl chains of fatty acids and cholesterol) facing toward the middle of the membrane; (b) hydrophilic components (phosphate, carboxyl, and amino groups of phospholipids) oriented outward toward the cytoplasmic and extracellular surfaces; and (c) proteins layered over both outer and inner surfaces, attached to the hydrophilic portions of the lipid bilayer by ionic bonds.It is clear that the Davson-Danielli structure, although possibly present . . .
Gynecomastia in renal failure.
Authors: D. M. Wilkinson
Journal: BMJ (1968)

uncomplicated chronic renal failure without regular dialysis treatment.In 1954, however, Wheeler et al. reviewed 160 cases of gynae- comastia collected over a 10-year period.3Bilateral gynaecomastia was noted in four patients in whom chronic pyelonephritis or chronic glomerulonephritis was the under- lying disease.Hypertension and decreased renal function were present in three, and atrophic testes were noted in two of these patients.Although we have also observed gynaecomastia in the non-dialysed uraemic patient, its incidence seems to be greatly increased by maintenance haemodialysis.The resemblance to refeeding gynaecomastia is indeed striking.-Weare, etc.,
Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target
Authors: Silvia Pascale, Giovanna Petrucci, Alfredo Dragani, Aida Habib, Francesco Zaccardi, Francesca Pagliaccia, Davide Pocaterra, Enzo Ragazzoni, Giancarlo Rolandi, Bianca Rocca, Carlo Patrono
Journal: Blood (2012)
Risk of Arrhythmia and Sudden Death
Authors: Gregory Y H Lip
Journal: Journal of the Royal Society of Medicine (2002)

Cardiac arrhythmias are common, and some have a regrettable tendency to cause sudden cardiac death. Greater efforts are needed in defining the clinical epidemiology, pathophysiology, risk stratification, risk assessment and therapeutic strategies in this area. Sudden death is not simply due to ventricular arrhythmias: other arrhythmias can be associated, as can certain drug therapies and congenital syndromes.

Professor Malik has assembled a comprehensive treatise on this theme, with subject-matter ranging from risk stratification and assessment to trials of antiarrhythmic agents. The contributors do their topics justice while not assuming too much knowledge in the reader; so non-specialists will find the book useful. An enjoyable section on clinical assessment starts by reminding us that ‘one should never manage arrhythmias but patients with arrhythmias’.

The section on clinical studies is impressive, ranging from myocardial infarction and chronic heart failure to atrial fibrillation. With my personal biases towards irregularly irregular things, my book reviews tend to focus on irregular rhythms. A criticism of the chapter on persistent atrial fibrillation is that it deals more with ‘how to manage the problem’ rather than the specific issue of preventing sudden death. Regarding drug-resistant paroxysmal atrial fibrillation, enthusiasm for ablate-and-pace should be tempered by the knowledge that this intervention itself can cause sudden death.

Overall this is an impressive tome: the editor and contributors are to be congratulated for assembling a wealth of material in a digestible form. Most cardiologists (irregularly irregular ones, or otherwise) and their departments should have a copy.
Abstract 3151: Posttranscriptional regulation of p21 by MCG10, an RNA-binding protein and a target of tumor suppressor p53
Authors: Ariane Scoumanne, Seong Jun Cho, Xinbin Chen
Journal: Cancer Research (2010)

Abstract The tumor suppressor p53 plays a crucial role in regulating many cellular processes, such as cell cycle arrest, apoptosis, senescence and cell metabolism, in response to stress signals. As a transcription factor, p53 modulates the expression of a plethora of genes, including p21, Killer/DR5, GADD45, TIGAR and MDM2. The tumor suppressor function of p53 is further underscored by the high propensity of p53 mutations found in human cancer. RNA-binding proteins are key modulators in RNA metabolism involved in alternative splicing, mRNA stability, mRNA transport as well as translation. Abnormal expression of RNA-binding proteins is implicated in a growing number of human diseases ranging from neurological disorders to cancer. Here, we showed that MCG10, an RNA-binding protein and a target of p53, regulates the stability of cell cycle inhibitor p21 transcript. Indeed, we found that MCG10 decreases p21 levels induced upon DNA damage. In addition, we showed that MCG10 directly binds to the 3′untranslated region of p21 transcript to destabilize it. Furthermore, we generated MCF7 breast adenocarcinoma and RKO colon carcinoma cell lines in which MCG10 is inducibly knocked down. We found that MCG10 is required for cell proliferation. In addition, we showed that deficiency in MCG10 leads to an increase in basal and DNA damage-induced p21 levels. Taken together, we uncovered a role for RNA-binding protein MCG10 in modulating the p53 pathway through posttranscriptional regulation of p21. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3151.
Some Sand for the Tracks
Authors: Wesley W. Hall
Journal: JAMA (1972)

Our main business is not to<i>see</i>what lies dimly at a distance, but to<i>do</i>what lies clearly at hand. Thus spoke the Seventh Earl of Carlisle over a century ago. Two years ago you, the members of this House of Delegates, chose me to serve as your President-Elect. One year ago I was installed as your President. This is one of the greatest honors that can be conferred upon a physician. An honor—Yes! But you gave me a<i>job</i>to do—to help represent the medical profession to emphasize across the width and breadth of this land that our profession is one of<i>service</i>to our patients and the American public, a magnificent profession. During the past two years I have attempted to visit with every doctor possible at every medical meeting I have attended. Every meeting has been a pleasant experience and very rewarding. Of all the