tbuckley/cabot-search huggingface dataset:
The effect of ouabain on the isolated sinus node preparation of the rabbit studied with microelectrodes.
Authors: G Steinbeck, F I Bonke, M A Allessie, W J Lammers
Journal: Circulation Research (1980)

In 30 isolated, spontaneously beating right atrial preparations of the rabbit, the arrhythmogenic actions of ouabain were studied with microelectrodes. Ouabain (10(-6) M) uniformly produced the following events: (1) a gradual increase in sinus rate with periods of alternation of beta-to-beat atrial intervals, (2) a rapid rate and regular rhythm, (3) severe irregularity of rhythm, (4) total atrial arrest. Cycle length decreased from 394 msec +/- 43 (mean +/- SD) during control to 229 msec +/- 26 during the period of rapid rate and regular rhythm (P less than 0.001). Pretreatment with atropine or propranolol did not abolish this positive chronotropic action of ouabain. Maps of the spread of activation in the area of the sinus node in eight experiments revealed that the speeding up of rate is accompanied by a shift of dominant pacemaker site toward the sinoatrial border. In explanation, it is shown that sinoatrial border fibers develop strong diastolic depolarization, whereas dominant pacemaker fibers do so to a lesser extent or not at all. The atrial arrhythmias--best to be described as "digitalis-induced sinus tachycardia"--may represent the experimental counterpart of the so-called "paroxysmal atrial tachycardia with block" described as a common manifestation of digitalis intoxication in man.
New Trends in Alexithymia Research
Authors: Graeme J. Taylor, R. Michael Bagby
Journal: Psychotherapy and Psychosomatics (2004)

Research investigating the alexithymia construct is advancing rapidly and has broadened considerably in recent years as a result of interdisciplinary efforts, new methodologies, and experimental techniques. New developments in the field include a shift from measurement-based validational studies to experimental investigations, which explore the relation between alexithymia and various aspects of emotional processing; the use of functional brain imaging techniques to explore neural activity associated with alexithymia; and experimental studies that measure multiple indices of physiological response to standardized emotion-inducing stimuli. Developmental research and attachment studies are providing ways for investigating potential etiological sources of the construct; and experimental approaches are being used to explore relations between alexithymia and other health-related personality constructs. In addition, longitudinal and treatment studies are clarifying the relation between alexithymia and psychopathology and the extent to which alexithymia predicts treatment outcome. Investigators need to embrace the new methods and techniques for the field of research to further increase understanding of the alexithymia construct and its association with physical and mental illness.
EFFECT OF ALTERED INTRATHORACIC PRESSURE ON RENAL HEMODYNAMICS, ELECTROLYTE EXCRETION AND WATER CLEARANCE*
Authors: H. V. Murdaugh, H. O. Sieker, F. Manfredi
Journal: Journal of Clinical Investigation (1959)

humoral factors in the production of the changes in rate of urine flow in response to pressure breathing with particular emphasis on the effects upon water clearance.METHODS
Searching for a Pulse
Authors: Woods Nash
Journal: Annals of Internal Medicine (2014)

Ad Libitum16 September 2014Searching for a PulseWoods Nash, MPH, PhDWoods Nash, MPH, PhDFrom McGovern Center for Humanities and Ethics, The University of Texas Medical School at Houston, Houston, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-0894 Audio Reading - “Searching for a Pulse” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "The Other Side," by I. Genao. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It bears all that we have known.... Author, Article, and Disclosure InformationAffiliations: From McGovern Center for Humanities and Ethics, The University of Texas Medical School at Houston, Houston, Texas.Current Author Address: Woods Nash, MPH, PhD; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Searching for a Pulse” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "The Other Side," by I. Genao. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byA Custom Low-Noise Silicon Photodiode Detector Designed for Use With X-Ray Capillary Optics 16 September 2014Volume 161, Issue 6Page: 460KeywordsAnesthesiaBloodBoneHeart rateRivers ePublished: 16 September 2014 Issue Published: 16 September 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1
Authors: Jurgen A. F. Marteijn, Laurens T. van der Meer, Liesbeth van Emst, Simon van Reijmersdal, Willemijn Wissink, Theo de Witte, Joop H. Jansen, Bert A. Van der Reijden
Journal: Blood (2007)
AB0962 Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: A randomized, double-blind, placebo-controlled international trial
Authors: C. Cooper, R. Chapurlat, C. Christiansen, H. Genant, N. Bellamy, W. Bensen, F. Navarro, J. Badurski, E. Nasonov, X. Chevalier, P. Sambrook, T. Spector, J.-Y. Reginster
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Strontium ranelate (SrRan) has potential beneficial effects on cartilage degradation in OA, stimulating human cartilage matrix formation in vitro and decreasing the urinary C-terminal telopeptides of type II-collagen. SrRan has also been shown to reduce radiographic spinal OA progression and back pain in osteoporotic women with prevalent spinal OA. <h3>Objectives</h3> We compared the efficacy and safety of SrRan with placebo in the treatment of knee osteoarthritis in a double-blind, placebo-controlled, randomised, international study (registration number: ISRCTN41323372) designed in accordance with the European Guidelines. <h3>Methods</h3> Patients with primary knee osteoarthritis, Kellgren and Lawrence grade 2 or 3, joint space width (JSW) 2.5 to 5 mm, and knee pain intensity of at least 40 mm on a visual analogue scale during the month prior to selection, were randomly allocated to SrRan 1 or 2 g/day, or placebo using a centralised interactive voice response system. The primary endpoint was radiographic joint space narrowing measured as the mean change in the minimal JSW of the knee medial tibiofemoral compartment with a semiautomated centralised reading method. JSW was measured at inclusion, 12, 24, and 36 months on radiographs with a postero-anterior, weight-bearing, fixed-flexion acquisition technique. Main secondary endpoints were changes in algofunctional scores (WOMAC), changes in knee pain intensity, and proportion of radiological progressors (patients with knee JSN&gt;0.5 mm). Safety was assessed by adverse events and haematology/biochemistry/haemostasis parameters. <h3>Results</h3> Detailed results will be presented. The patients were included in 113 centres in 18 countries. 558 patients were assigned to SrRan 1 g/day, 566 to 2 g/day, and 559 to placebo. Mean follow-up was 29.8±10.5 months. Mean age was 62.8±7.2 years and 69% were female. Mean BMI was 30±5 kg/m<sup>2</sup>, mean JSW was 3.50±0.83 mm, and 61% of randomised patients were Kellgren and Lawrence stage II. <h3>Conclusions</h3> This large randomised placebo-controlled study will establish the long-term efficacyof SrRan on structure and symptoms in patients with knee osteoarthritis. <h3>Disclosure of Interest</h3> None Declared
TCT-830 The risk of acute kidney injury following primary percutaneous coronary interventions is lower with the transradial approach. Results from the PRIPITENA urban registry
Authors: Bernardo Cortese, Alessandro Sciahbasi, Rodrigo Sebik, Stefano Rigattieri, Alessandro Alonzo, Pedro Silva Orrego, Flavia Belloni, Romano Giuseppe Seregni, Francesca Giovannelli, Maurizio Tespili, Roberto Ricci, Andrea Berni
Journal: Journal of the American College of Cardiology (2014)
Separation of anxiety and depressive disorders: New tools will lead to more valid classification system
Authors: M. B First
Journal: BMJ (2003)

Editor—Shorter and Tyrer's comments about the implications of separating depressive and anxiety disorders in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM) are perplexing, but not enlightening.1

Implying that this separation is impeding the development of new antidepressants, the authors cite an inverse relation between the number of patented new drugs and the number of DSM categories, then acknowledge that this association may not be causal. They call for companies to develop drugs targeting the heterogeneous category of mixed anxiety and depression but ignore the added cost resulting from the huge sample sizes of patients that would be needed to see even small drug effects.

Finally, the authors incorrectly assert that the drug industry significantly influences the diagnostic revision process. No facet of the DSM-IV revision process entailed any pharmaceutical company support.

We contend that the Food and Drug Administration's approval of compounds for multiple, diagnosis specific indications reflects their broad spectrum of efficacy and has no bearing on the pace of new drug development. Moreover, adopting broadly defined indications could encourage over-prescribing by blurring the diagnostic threshold that separates “normal” depression and anxiety from pathological states.

Certainly the biggest hindrance to both successful new drug development and the utility of the DSM classification is our current lack of understanding of the underlying pathophysiology of psychiatric disorders. New tools ranging from neuroimaging to functional genomics will help to elucidate the pathophysiology of mood and anxiety disorders, leading to a more valid classification system and, in turn, accelerated development of new medications.
Involvement of bradykinin in acute exercise-induced increase of glucose uptake and GLUT-4 translocation in skeletal muscle: Studies in normal and diabetic humans and rats
Authors: Tetsuya Taguchi, Hideki Kishikawa, Hiroyuki Motoshima, Kohji Sakai, Toshihiko Nishiyama, Kazuaki Yoshizato, Atsuhisa Shirakami, Tetsushi Toyonaga, Tetsuya Shirotani, Eiichi Araki, Motoaki Shichiri
Journal: Metabolism (2000)
Cognitive Dissonance
Authors: C. Carl Jaffe
Journal: JAMA (1979)

THE PROLIFERATION of new medical imaging technology has led to a new problem in the interpretation of diagnostic findings—the occasional conflicting report in which only one of several imaging procedures demonstrates an abnormality in the same patient. When fewer imaging techniques were available and the clinical indications for each were more clearly defined, contradictory results were less common. Currently, a larger repertoire of imaging procedures is being used to search similar regions of the same patient for a suspected pathological condition. Each imaging modality—roentgenography, angiography, nuclear medicine, computerized tomography, and ultrasound—possesses unique degrees of sensitivity and specificity that have yet to be fully established for all clinical situations. As these multiple tests are employed for the same patient, conflicting results occasionally should be expected. How does this occur, and how is a clinician to resolve such a dilemma? Much early progress in medical imaging arose from modifications that improved the
Postprandial concentrations of free and conjugated bile acids down the length of the normal human small intestine
Authors: T. C. Northfield, I. McColl
Journal: Gut (1973)

Small intestinal samples were obtained by intubation from multiple sites along the small intestine in 11 subjects with no known gastrointestinal disease eating a normal diet and at laparotomy in a further three subjects. Free (unconjugated) bile acids were consistently demonstrated in ileal samples, and occasionally in lower jejunal samples, by thin-layer chromatography, supplemented in some cases by gas/liquid chromatography and by infrared spectroscopy. The free bile acid concentration, measured enzymically following thin-layer chromatography, reached a maximum (1 mM) in the lower ileum, where it represented half the total bile acid concentration. Following ampicillin, the concentration of free bile acids decreased markedly, suggesting that they resulted from bacterial deconjugation; at the same time the total bile acid concentration increased, suggesting impaired absorption due to the reduced concentration of the more rapidly absorbed free bile acids. Our results indicate that the presence of free bile acids in lower jejunal and ileal samples is a normal finding, and cannot be taken as evidence of abnormal bacterial overgrowth. They also suggest that bacterial deconjugation at these sites may be a factor contributing to the remarkable efficiency of bile salt reabsorption.
A Monoclonal IgM Protein with Antibody-like Activity for Human Albumin
Authors: Stephen Hauptman, Thomas B. Tomasi
Journal: Journal of Clinical Investigation (1974)

The serum of a patient (L'ec) with an IgM lambda monoclonal protein was noted to bind albumin on immunoelectrophoresis. Analytical ultracentrifugation of the L'ec serum demonstrated 23S and 12S peaks, but no 4S (albumin) boundary. Immunologically identical 20S and 9S IgM proteins were isolated from the serum and the addition in vitro of either the patient's albumin or albumin isolated from normal serum was shown to reconstitute the 23S and 12S boundaries. The binding of high molecular weight IgM to albumin was demonstated by Sephadex G200 chromatography with (125)I-labeled albumin and isolated IgM. Immunoelectrophoresis of the L'ec IgM developed with aggregated albumin (reverse immunoelectrophoresis) also demonstrated the binding of albumin to IgM. That all of the patient's IgM complexed with albumin was shown by affinity chromatography employing an aggregated albumin-immunoadsorbent column. Binding was shown to be of the noncovalent type by polyacrylamide gel electrophoresis in 8 M urea. With hot trypsin proteolysis, Fabmu and Fcmu5 fragments were isolated, and monomer albumin was shown to complex only with the Fabmu fragment by both analytical ultracentrifugation and molecular sieve chromatogaphy employing (125)I-labeled Fab fragments. 1 mol of Fabmu fragment bound 1 mol of monomer albumin. Polymers of human albumin, produced by heat aggregation, precipitated with the isolated L'ec protein on gel diffusion analysis and, when coated on sheep red blood cells, gave a hemagglutination titer greater than 1 million with the whole L'ec serum. 50 additional monoclonal IgM, 33 IgA, and 80 IgG sera failed to show precipitation or hemagglutination with aggregated albumin. Native monomer albumin inhibited precipitation only at high concentrations (> 50 mg/ml); dimer albumin or fragments of albumin produced by trypsin digestion inhibited at low concentrations (0.4 mg/ml). No reactivity occurred with the albumin of five other mammalian species, including bovine. The L'ec protein has the characteristics of an antibody against aggregated albumin, which also has reactivity with native (monomer) albumin. This system shares many similarities with the reaction of IgM human rheumatoid factors with IgG antigen.
Condition of Polish Refugees
Authors: R. W. B. Ellis, D. O'Donovan, F. M. Wilson
Journal: BMJ (1939)

The following report is based -on an investigation of refugee conditions carried out under the auspices of the Society of Friends and the Polish Relief Fund between October 17 and November 3.During this time some twenty-three military camps and civilian centres were inspected in Rumania and Hungary.The fullest co- operation was given by the civil and military authorities in both countries in the inspection of records and accommo- dation, and in permission to talk freely with Polish soldiers and civilians.Exact figures regarding the total numbers and classification of refugees are not yet available owing to registration being incomplete, the uncontrolled movement of civilians, and the entrance of stragglers over the Russian frontier, which still continues.There appear, however, to be 30,000 to 35,000 in Rumania, of which 10,000 are civilians; 48,000 to 50,000 in Hungary, of which again some 10,000 are civilians.Women and young children form less than a fifth of the civilians, and there are very few young children without at least one parent.There are, however, some six hundred or more Polish boy scouts and other boys of from 12 to 18 who came over with the army; many of these have in Hungary been interned with the soldiers.There are also several hundred students in both countries.About half the male civilians are "function- aries "-postmen, police, civil servants, etc.-who were evacuated by the Polish Government.Only a small number of peasants appear to have crossed the frontier.
β-Arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation
Authors: Raffaella Molteni, Carolina Lage Crespo, Sara Feigelson, Christian Moser, Monica Fabbri, Valentin Grabovsky, Fritz Krombach, Carlo Laudanna, Ronen Alon, Ruggero Pardi
Journal: Blood (2009)
Autoantibodies to cartilage and type II collagen in relapsing polychondritis and other rheumatic diseases.
Authors: R Ebringer, G Rook, G T Swana, G F Bottazzo, D Doniach
Journal: Annals of the Rheumatic Diseases (1981)

Cartilage antibodies were demonstrated by indirect immunofluorescence (IFL) on human fetal cartilage in 6 out of 9 patients with relapsing polychondritis (RPC), in 4 out of 260 patients with rheumatoid arthritis (RA), and in only 1 out of 1016 patients with other disorders. The antibodies were specific for cartilage and evenly stained the whole cartilage matrix. They were predominantly of IgG class and varied in titres from 1:1 to 1:320. Follow-up studies in the RPC patients indicated that higher titres were present during the early acute phase of the disease. Five of the 6 positive cases had developed the disease within the past 12 months, and the 3 negative cases had had the disease for 3 to 7 years when tested. The RA cases showing positive cartilage IFL had no clinical evidence of RPC. Sequential measurements in 2 of the 4 cases showed that these antibodies became detectable some years after the onset of arthritis. Absorption studies with human type II collagen and purified porcine proteoglycan failed to remove the cartilage IFL. Antibodies to human native type II collagen were measured by an enzyme-linked immunosorbent assay. The highest levels were found in the RA sera which also displayed cartilage IFL, but the 2 tests gave discordant results. RPC sera showed the same antibody levels by this method, as did cartilage-IFL-negative RA sera, though both groups had higher mean levels than health controls. The findings that cartilage antibodies are detected in the majority of cases of RPC and only rarely in other diseases suggests these antibodies may play an important role in the pathogenesis of cartilage destruction in RPC.
A science of culture: Clarifications and extensions
Authors: Alex Mesoudi, Andrew Whiten, Kevin N. Laland
Journal: Behavioral and Brain Sciences (2006)

We are encouraged that the majority of commentators endorse our evolutionary framework for studying culture, and several suggest extensions. Here we clarify our position, dwelling on misunderstandings and requests for exposition. We reiterate that using evolutionary biology as a model for unifying the social sciences within a single synthetic framework can stimulate a more progressive and rigorous science of culture.
Myocardial kinetics of Tc-MIBI in canine myocardium after dipyridamole.
Authors: D K Glover, R D Okada
Journal: Circulation (1990)

Technetium 99m-hexakis-2-methoxy-2-methylpropyl-isonitrile (Tc-MIBI) is a promising new myocardial perfusion imaging agent producing excellent rest images. Imaging, however, will need to be performed with exercise or dipyridamole to detect ischemia and to differentiate salvaged but still ischemic myocardium from scar. Accordingly, 12 dogs were given mild-to-moderate left circumflex coronary stenoses (group 2), and 10 dogs were given severe stenoses (group 3). In five control dogs (group 1), there was no stenosis. After an intravenous infusion of dipyridamole (0.08 mg/kg/min for 4 minutes), Tc-MIBI was injected into the right atrium. Over the next 4-hour study period, myocardial Tc-MIBI activities were continuously monitored in both the left anterior descending (LAD) (normal) and left circumflex (LCx) (ischemic) coronary artery (ischemic) zones using miniature cadmium telluride radiation detectors and serial gamma camera images were acquired when necessary. Tc-MIBI was rapidly taken up by nonischemic, mild-to-moderate, and severe ischemic myocardium. The initial myocardial uptake of Tc-MIBI was linearly related (r = 0.97) to regional myocardial blood flow at rates up to 2.0 ml/min/g. After the initial uptake, the mean 4-hour fractional myocardial clearance was similar between the control (0.09 +/- 0.03 [+/- SEM]) and group 2 (0.07 +/- 0.03) and group 3 (0.09 +/- 0.03) ischemic zones. Tc-MIBI blood clearance was rapid and biexponential with an initial fast clearance phase followed by a slow clearance phase.(ABSTRACT TRUNCATED AT 250 WORDS)
Hysterectomy: will it pay the bills in 2007?
Authors: R J Lilford
Journal: BMJ (1997)

without reference to patients' views, with no attempt to involve users in their planning and operation, and with limited efforts to assess patient satisfaction.Without evidence to support a need for uniform standards of service and care, and without a clear idea of what those standards should be, they are likely to maintain their independence of action, as practice rotas have always done.Uniformity is not necessarily a virtue in circumstances where needs and demands for care differ.The importance of flexibility in order to address local needs and circumstances, particularly where services are poor, lies at the heart of the recent government white paper on primary care. 18However, equality of access to uniformly high standards of care is an important goal for primary health care, and increasing variability in the organisation and delivery of out of hours services should not lead to increasing inequality.