Uremia and Cardiovascular Mortality
Authors: SANDOR A. FRIEDMAN
Journal: Annals of Internal Medicine (1974)

Editorial Notes1 November 1974Uremia and Cardiovascular MortalitySANDOR A. FRIEDMAN, M.D., F.A.C.P., HERMAN ROSEN, M.D., F.A.C.P.SANDOR A. FRIEDMAN, M.D., F.A.C.P.Search for more papers by this author, HERMAN ROSEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-5-696 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProlongation of life by maintenance hemodialysis has led to the discovery of several long-term uremic complications. The newest one is accelerated degenerative cardiovascular disease. Lindner and associates (1) reported, from a retrospective study of 39 patients (mean age, 37 years) who received hemodialysis in Seattle after 1960, a 56.4% mortality in a 13-year period. Fourteen of 23 deaths were due to cardiovascular disease, including myocardial infarction in 8 cases and strokes in 3. The cumulative incidence of coronary artery disease was 52.5% after 10 years, more than 20 times that expected for normal persons of similar age and even higher...References1. LINDNER A, CHARRA B, and SHERRARD D: Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Eng J Med 290:697-701, 1974 CrossrefMedlineGoogle Scholar2. DEFRONZO R, ANDRES R, and EDGAR P: Carbohydrate metabolism in uremia: a review. Medicine (Baltimore) 52:469-481, 1973 CrossrefMedlineGoogle Scholar3. BAGDADE J, PORTE D, and BIERMAN E: Hypertriglyceridemia: a metabolic consequence of chronic renal failure. N Eng J Med 279:181-185, 1968 CrossrefMedlineGoogle Scholar4. ALBRINK M: Triglycerides, lipoproteins, and coronary artery disease. Arch Intern Med 109:345-359, 1962 CrossrefMedlineGoogle Scholar5. JOHNSON C, GRAHAM C, and CURTIS F: Roentgenographic manifestations of chronic renal disease treated by periodic hemodialysis. Am J Roentgenol Radium Ther Nucl Med 101:915-926, 1967 CrossrefMedlineGoogle Scholar6. FRIEDMAN S, NOVACK S, and THOMSON G: Arterial calcification and gangrene in uremia. N Engl J Med 280:1392-1394, 1969 CrossrefMedlineGoogle Scholar7. MASSRY S, GORDON A, and COBURN J: Vascular calcification and peripheral necrosis in a renal transplant recipient. Am J Med 49:416-422, 1970 CrossrefMedlineGoogle Scholar8. ROSEN H, FRIEDMAN S, and RAIZNER A: Azotemic arteriopathy. Am Heart J 84:250-255, 1972 CrossrefMedlineGoogle Scholar9. MALLICK N and BERLYNE G: Arterial calcification after vitamin-D therapy in hyperphosphatemic renal failure. Lancet 2:1316-1319, 1968 CrossrefMedlineGoogle Scholar10. BRICKER N: On the pathogenesis of the uremic state. An exposition of the "trade-off hypothesis." N Engl J Med 286:1093-1099, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SANDOR A. FRIEDMAN, M.D., F.A.C.P.; HERMAN ROSEN, M.D., F.A.C.P.Affiliations: Department of Medicine Coney Island Hospital Brooklyn, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOsteoporosis and atherosclerosis in chronic renal failureArterial Calcifications in Uraemic Rats Treated with 1-α-Hydroxycholecalciferol and ParathyroidectomyStörungen des Fettstoffwechsels und der GlukosetoleranzErh�htes Serum-Myoglobin bei NiereninsuffizienzThe role of hypertension in hemodialysis-associated atherosclerosisRegular Dialysis TreatmentClofibrate disposition in renal failure and acute and chronic liver diseaseUraemic Arterial DiseaseThromboendarterectomy for Anuria 4½ Years Post-Renal Transplant: A Case ReportRenal Disease in the ElderlyCardiovascular Disease and DialysisTHOMAS P. GIBSON, M.D., WILLIAM A. BRIGGS, M.D., F.A.C.P., BETTY BOONE, PH.D.Calcific Cardiomyopathy 1 November 1974Volume 81, Issue 5Page: 696-697KeywordsCardiovascular diseasesMortalityMyocardial infarctionRetrospective studiesStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 November 1974 PDF downloadLoading ...