tbuckley/cabot-search huggingface dataset:
Towards optimization of an organotypic assay system that imitates human hair follicle-like epithelial-mesenchymal interactions
Authors: B. Havlickova, T. Biro, A. Mescalchin, P. Arenberger, R. Paus
Journal: British Journal of Dermatology (2004)

Journal Article Towards optimization of an organotypic assay system that imitates human hair follicle‐like epithelial–mesenchymal interactions Get access B. Havlickova, B. Havlickova Department of Dermatology, University Hospital Hamburg‐Eppendorf, University of Hamburg, D‐20246 Hamburg, GermanyDepartment of Dermatology, 3rd Medical Faculty, Charles' University Hospital, CZ‐10037 Prague, Czech Republic Search for other works by this author on: Oxford Academic Google Scholar T. Bíró, T. Bíró Department of Physiology, Medical and Health Science Center, University of Debrecen, H‐4012 Debrecen, Hungary Search for other works by this author on: Oxford Academic Google Scholar A. Mescalchin, A. Mescalchin Cutech Srl, I‐35100 Padova, Italy Search for other works by this author on: Oxford Academic Google Scholar P. Arenberger, P. Arenberger Department of Dermatology, 3rd Medical Faculty, Charles' University Hospital, CZ‐10037 Prague, Czech Republic Search for other works by this author on: Oxford Academic Google Scholar R. Paus R. Paus Department of Dermatology, University Hospital Hamburg‐Eppendorf, University of Hamburg, D‐20246 Hamburg, Germany Ralf Paus, MD. E‐mail: paus@uke.uni‐hamburg.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 4, 1 October 2004, Pages 753–765, https://doi.org/10.1111/j.1365-2133.2004.06184.x Published: 01 October 2004 Article history Accepted: 25 February 2004 Published: 01 October 2004
Long-term Effects of Angiopeptin Treatment in Coronary Angioplasty
Authors: Håkan Emanuelsson, Kevin J. Beatt, Jens-Peder Bagger, Raphael Balcon, Juhani Heikkilä, Jan Piessens, Marc Schaeffer, Harry Suryapranata, Marie Foegh, for the European Angiopeptin Study Group
Journal: Circulation (1995)

Background Angiopeptin is a cyclic octapeptide analogue of somatostatin that has been shown to limit myointimal thickening of arteries in balloon injury models and to restore the vasodilating response to acetylcholine. A randomized, double-blind placebo controlled trial was conducted to assess the effect of angiopeptin in restenosis prevention after percutaneous transluminal coronary angioplasty (PTCA). Methods and Results Patients received a continuous infusion of either placebo or angiopeptin subcutaneously 6 to 24 hours before PTCA and for 4 days after PTCA (3 mg per 24 hours before PTCA followed by 6 mg per 24 hours after PTCA and for the remaining period). A 1.5-mg bolus dose of placebo or angiopeptin was given at PTCA. Aspirin (acetylsalicylic acid, 150 mg/d) was administered throughout the study period. Coronary angiograms obtained before and after PTCA and at 6-month follow-up were subjected to computerized quantification. Clinical follow-up was performed after 12 months. Primary clinical end points were death, myocardial infarction, coronary artery bypass surgery, or repeat PTCA. In total, 553 patients with 742 lesions were randomized. Clinical follow-up was available for all 553 patients. Angiopeptin decreased the clinical events during 12 months of follow-up from 36.4% in the placebo-treated group to 28.4% in the angiopeptin-treated patients ( P =.046). Quantitative angiography after PTCA and at follow-up was available in 423 of 455 patients who underwent successful PTCA. The minimal lumen diameter at follow-up was 1.52±0.64 mm in the angiopeptin-treated group compared with 1.52±0.64 mm in the placebo-treated patients ( P =.96). The late losses were 0.31±0.59 and 0.30±0.62 mm ( P =.81) and the restenosis rates (&gt;50% diameter stenosis at follow-up) were 36% and 37% ( P =.85) in the angiopeptin- and placebo-treated groups, respectively. Conclusions In this study, angiopeptin significantly decreased the incidence of clinical events, principally the rate of revascularization procedures. In contrast, no significant effect was seen on angiographic variables.
Do-it-yourself medicine.
Authors: A Savage
Journal: BMJ (1982)

The uncertainties in this investigation began at the beginning, for no one ever knew the name, or even the age, of the little girl who became the index case. She was admitted unconscious with no history and a couple of days later she died, but before she did a distended, tympanitic, silent abdomen gave the clue, and rectal examination showed total absence of the anterior wall. During the succeeding month two more toddlers died in the same manner. To set the scene : the children's medical ward at St Elizabeth's Hospital, Lusikisiki, Transkei, has 15 cots in a floor space of about 24x18 ft (7x6 m). These cots usually contain 40-50 children, roughly arranged in a form of progressive care. Next to this main ward is a succession of smaller rooms, containing the gastros, a dozen or so, mainly on intravenous treatment; a variable number (but always far too many) of children severely ill with tuberculosis, all needing triple therapy; isolation cases; and, lastly, those with measles. Ward rounds were a daily battle against time for at 1015 came the blessing of tea, and 15 minutes later the daily grind of OPD (outpatients department). Once imprisoned in the small concrete cell that represented the children's clinic there was little chance to return to the ward, except to officiate at the only too frequent death beds. Death was indeed commonplace.
Breast Cancer after Prophylactic Bilateral Mastectomy in Women with a<i>BRCA1</i>or<i>BRCA2</i>Mutation
Authors: Hanne Meijers-Heijboer, Bert van Geel, Wim L.J. van Putten, Sonja C. Henzen-Logmans, Caroline Seynaeve, Marian B.E. Menke-Pluymers, Carina C.M. Bartels, Leon C. Verhoog, Ans M.W. van den Ouweland, Martinus F. Niermeijer, Cecile T.M. Brekelmans, Jan G.M. Klijn
Journal: New England Journal of Medicine (2001)

Women with a BRCA1 or BRCA2 mutation have a high risk of breast cancer and may choose to undergo prophylactic bilateral total mastectomy. We investigated the efficacy of this procedure in such women.
A CASE OF CIRCULAR INSANITY STUDIED FROM CLINICAL, DIFFERENTIAL AND FORENSIC STANDPOINTS.
Authors: RICHARD DEWEY
Journal: JAMA (1904)

<h3>INTRODUCTION.</h3> The case of X. merits study from several points of view: First, with reference to diagnosis owing to the conflicting opinions expressed by experts during the patient's lifetime, as to the form of mental disease; also in a medicolegal sense, on account of the great number and variety of legal contests growing out of the patient's mental condition, in which he himself actively and often brilliantly participated. The case also incidentally involves the study of a remarkable personality, and the clinical history consists largely in the narration of extraordinary acts, "antics" and vagaries of a mad but acute and brilliant mind. Finally the findings resulting from the examination of the brain present much of interest in both a positive and negative sense. The following statement of the case has been prepared from personal observation of the patient when under my care in the State Hospital
Radiotherapy after Breast-Preserving Surgery in Women with Localized Cancer of the Breast
Authors: Umberto Veronesi, Alberto Luini, Marcella Del Vecchio, Marco Greco, Viviana Galimberti, Mirella Merson, Franco Rilke, Virgilio Sacchini, Roberto Saccozzi, Tommaso Savio, Roberto Zucali, Stefano Zurrida, Bruno Salvadori
Journal: New England Journal of Medicine (1993)

Conservative surgery and radiotherapy have become well-established treatments for breast cancer, and many trials in progress are attempting to define the most acceptable type of procedure. Between 1987 and 1989 we randomly assigned 567 women with small breast cancers (<2.5 cm in diameter) to quadrantectomy followed by radiotherapy or to quadrantectomy without radiotherapy. All patients underwent total axillary dissection. The median follow-up period was 39 months (range, 28 to 54).
Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus
Authors: CD.A. Stehouwer, G.C. Zeldenrust, GJ.H. den Ottolander, W.H.L. Hackeng, A.J.M. Donker, J.J.P. Nauta
Journal: The Lancet (1992)
Educational Programs of Allied Medical Services
Authors: A. N. Taylor
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The interval ejection fraction: a cineangiographic and radionuclide study.
Authors: A J Kemper, J A Bianco, R M Shulman, E D Folland, A F Parisi, D E Tow
Journal: Circulation (1982)

To evaluate the clinical usefulness of the first-third ejection fraction (1/3 EF) for detecting patients with coronary artery disease (CAD), resting contrast ventriculography and first-pass radionuclide angiography with a high-count-rate, multicrystal camera system were performed in 47 subjects: 22 normal controls (group 1) and 25 patients with clinically stable angina pectoris and severe CAD (mean 2.3 vessels) without (group 2, n = 12) and with (group 3, n = 13) resting wall motion abnormalities. By contrast angiography, only group 3 had depressed global EF or 1/3 EF compared with control (global EF: group 1,0.71 +/- 0.09; group 2, 0.67 +/- 0.09 [NS]; group 3,049 +/- 0.05 [p less than 0.01 vs groups 1 and 2]; 1/3 EF: group 1,0.29% +/- 0.06;' group 2, 0.28 +/- 0.05 [NS]; group 3,0.22 +/- 0.05 [p less than 0.02 vs groups 1 and 2]). Whereas 11 of 25 CAD patients had global EF outside the normal range, only two of 25 had depressed 1/3 EF. Both had left ventricular asynergy and a depressed global EF. Studies performed using first-pass radionuclide angiography revealed similar results i.e., only four of 25 CAD patients, all with left ventricular asynergy and depressed global EF, had depressed 1/3 EF values. A wide range of 1/3 EF values was found in normal subjects by both techniques. Thus, the ejection fraction during the first third of systole at rest is of limited value for detecting patients with CAD.
Get Syk and get cycling
Authors: Ruth Williams
Journal: The Journal of Experimental Medicine (2006)

Rampant proliferation of pre–B cells in leukemia can be caused by overly active proto-oncogenes such as c-Myc. Wossning et al. (page [2829][1]) now discover that this c-Myc surplus is driven by a tyrosine kinase called Syk. But even with lots of c-Myc, pre–B cells still need Syk to cycle.

B
Dietary exclusions for improving established atopic eczema in adults and children: systematic review
Authors: F. Bath‐Hextall, F. M. Delamere, H. C. Williams
Journal: Allergy (2009)

Atopic eczema is the most common inflammatory skin disease of childhood in developed countries. We performed a systematic review of randomized controlled trials to assess the effects of dietary exclusions for the treatment of established atopic eczema. Nine trials (421 participants) were included, most of which were poorly reported. Six were studies of egg and milk exclusion (n = 288), one was a study of few foods (n = 85) and two were studies of an elemental diet (n = 48). There appears to be no benefit of an egg- and milk-free diet in unselected participants with atopic eczema. There is also no evidence of benefit in the use of an elemental or few-foods diet in unselected cases of atopic eczema. There may be some benefit in using an egg-free diet in infants with suspected egg allergy who have positive specific IgE to eggs - one study found 51% of the children had a significant improvement in body surface area with the exclusion diet as compared with normal diet (95% CI 1.07-2.11) and change in surface area and severity score was significantly improved in the exclusion diet as compared with the normal diet at the end of 6 weeks (MD 5.50, 95% CI 0.19-10.81) and end of treatment (MD 6.10, 95% CI 0.06-12.14). Despite their frequent use, we find little good quality evidence to support the use of exclusion diets in atopic eczema.
Method for determining H2SO4 in automobile exhaust.
Authors: K L Kipp, D R Rhodes
Journal: Environmental Health Perspectives (1975)

A relatively simple procedure for measuring H2SO4 in auto exhaust will be presented. The system is compatible with the Federal constant volume sampler (CVS unit). The time required to get sufficient sample for titration is 15-30 min. Values on sulfates in exhaust with a catalyst car and a noncatalyst car agree well with literature data obtained by dilution tube and filtration techniques.
THE DIFFICULTIES OF PREVENTING ENTERIC FEVER IN WARFARE
Authors: C. Childs
Journal: BMJ (1902)

pulse was 102 per minute.The bowels had moved freely.Exophthalmos was slight, but the upper lids still lagged.On October 29th vomiting set in, and there, was frequent hiccough.The bromide and digitalis mixture was stopped.Mental excitement was increased.During the last few days
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
Authors: Bo Kong, Li Wang, John Y.L. Chiang, Youcai Zhang, Curtis D. Klaassen, Grace L. Guo
Journal: Hepatology (2012)

Activation of farnesoid X receptor (Fxr, Nr1h4) is a major mechanism in suppressing bile-acid synthesis by reducing the expression levels of genes encoding key bile-acid synthetic enzymes (e.g., cytochrome P450 [CYP]7A1/Cyp7a1 and CYP8B1/Cyp8b1). FXR-mediated induction of hepatic small heterodimer partner (SHP/Shp, Nr0b2) and intestinal fibroblast growth factor 15 (Fgf15; FGF19 in humans) has been shown to be responsible for this suppression. However, the exact contribution of Shp/Fgf15 to this suppression, and the associated cell-signaling pathway, is unclear. By using novel genetically modified mice, the current study showed that the intestinal Fxr/Fgf15 pathway was critical for suppressing both Cyp7a1 and Cyp8b1 gene expression, but the liver Fxr/Shp pathway was important for suppressing Cyp8b1 gene expression and had a minor role in suppressing Cyp7a1 gene expression. Furthermore, in vivo administration of Fgf15 protein to mice led to a strong activation of extracellular signal-related kinase (ERK) and, to a smaller degree, Jun N-terminal kinase (JNK) in the liver. In addition, deficiency of either the ERK or JNK pathway in mouse livers reduced the basal, but not the Fgf15-mediated, suppression of Cyp7a1 and Cyp8b1 gene expression. However, deficiency of both ERK and JNK pathways prevented Fgf15-mediated suppression of Cyp7a1 and Cyp8b1 gene expression. The current study clearly elucidates the underlying molecular mechanism of hepatic versus intestinal Fxr in regulating the expression of genes critical for bile-acid synthesis and hydrophobicity in the liver.
Scintigraphic Demonstration of Sequestered Nodular Goiter A Lateral Aberrant Thyroid Rest
Authors: REN SHYAN LIU, TZU CHEN YEN, SHIN HWA YEH, CHEN HSEN LEE
Journal: Clinical Nuclear Medicine (1992)

The authors describe the case of a 40-year-old woman with sequestered nodular goiter. A thyroid scan pattern showed nodular goiter and a functioning mass in the left lateral cervical area, but there was no significant concentration of I-131 between the mass and the thyroid gland. Sequestered nodular goiter, also called a lateral aberrant thyroid rest, is histologically benign thyroid tissue in the lateral cervical area and is entirely separated from the thyroid gland. This is a rare condition that occurs in older patients with colloid nodular goiter.
A Case of Thyroidectomy
Authors: J. P. Bramwell
Journal: BMJ (1886)

accumulation, was reported in the BRITISH MEDICAL JOURTAL of April 10th ; a similar case has since come under my own care, a brief report of which may also prove of interest to some of the readers of the JOURNAL.My patient, a married lady, is also about 50 years of age.She has always been healthy, has had a family, and there is no trace of here- ditary tendency to mental disease.The duration of mental unsound-
LONG-TERM OUTCOMES OF OFF-PUMP CABG AND PCI USING SIROLIMS-ELUTING STENT IN SEPTUAGENARIANS; A PROPENSITY ANALYSIS OF DIABETES PATIENTS WITH MULTIVESSEL DISEASE
Authors: Kan Kajimoto, Katsumi Miyauchi, Taira Yamamoto, Keiichi Tambara, Hirotaka Inaba, Kenji Kuwaki, Shizuyuki Dohi, Hiroshi Tamura, Ken Kurata, Hiroyuki Daida, Atsushi Amano
Journal: Journal of the American College of Cardiology (2011)
THROMBIN FORMATION. I. THE ROLE OF CALCIUM, SERUM AC-GLOBULIN AND TISSUE THROMBOPLASTIN 1
Authors: Jessica H. Lewis, J. H. Ferguson
Journal: Journal of Clinical Investigation (1948)

Recent investigations have shown that thrombin is not formed simply by the interaction of prothrom- bin and thromboplastin in the presence of calcium ion but that another factor(s) is important and perhaps necessary.Almost simultaneously various workers have described new factors but the differ- ent investigational approaches involved have made it difficult to determine if all factors discussed are identical.Quick (1-3) has described a labile factor disap- pearing from plasma on storage, but differing from the classical prothrombin.Owren (4-6) reported a new factor, "factor V," which he found dimin- ished in one patient and which he describes as "found in normal plasma, thermolabile, and im- portant to thrombin formation."He expresses its
Tranquilizers and Decline in Cardiovascular Mortality-Reply
Authors: William B. Kannel
Journal: JAMA (1982)

<h3>In Reply.—</h3> Dr Lutz's assertion that emotional stress has been overlooked as a major cardiovascular risk factor is not entirely correct. The possibility has been extensively researched during the past two decades.<sup>1</sup>For some psychosocial factors, the evidence has been highly suggestive; for others, the evidence is weak or inconsistent. Most sociological concepts have proved rather complex with respect to purported associations with coronary heart disease, including social mobility, status incongruity, occupation, education, marital status, and religious affiliation. Anxiety, depression, irritability, and sleeplessness, which may be taken as signs of emotional drain, have shown some relationship to coronary disease. The major obstacle to research in this area is the vagueness of the entity "emotional stress," defying precise definition and measurement. Symptoms and behavior characterized as "anxiety and neuroticism" have been reported to be related to coronary disease.<sup>1</sup>Also, social support systems seem to protect against health hazards associated
Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2
Authors: Marie Meeths, Miriam Entesarian, Waleed Al-Herz, Samuel C. C. Chiang, Stephanie M. Wood, Wafa Al-Ateeqi, Francisco Almazan, Jaap J. Boelens, Henrik Hasle, Marianne Ifversen, Bendik Lund, J. Merlijn van den Berg, Britt Gustafsson, Hans Hjelmqvist, Magnus Nordenskjöld, Yenan T. Bryceson, Jan-Inge Henter
Journal: Blood (2010)
GP is suspended for six months for altering patient's records
Authors: C. Dyer
Journal: BMJ (2014)

A Birmingham GP who retrospectively altered a cancer patient’s record and blamed it on a colleague has been suspended for six months by a fitness to practise panel. Nita Saikia Varman, who qualified in 1972, added notes to the record of a previous examination to make it seem more thorough than it had been.

“Patient A” attended Saikia Varman’s practice in June 2007 complaining of hoarseness. She recorded absence of rash, fever, or foreign body sensation and advised the patient to quit smoking …
Robust Adenoviral and Adeno-Associated Viral Gene Transfer to the In Vivo Murine Heart
Authors: Hunter C. Champion, Dimitrios Georgakopoulos, Saptarsi Haldar, Lili Wang, Yibin Wang, David A. Kass
Journal: Circulation (2003)

Viral gene transfer to the whole heart in vivo has been achieved in several mammalian species but remained difficult to accomplish in murine hearts. We postulated that a key impediment derives from the use of proximal aortic occlusion during virus injection, because this eliminates coronary perfusion gradients in mice as aortic root and left ventricle pressures equalize.Pressure-volume analysis confirmed these mechanics. In contrast, descending aortic occlusion with whole-body cooling (20 degrees C) preserved transmyocardial perfusion gradients and allowed for sustained (>10-minute) dwell times in an upper-body perfusion circuit. This approach yielded robust cardiac transfection with adenovirus (AdV) and adeno-associated virus (AAV) injected into the left ventricle cavity or more simply via a central vein. Cardio-specific expression was achieved with a myocyte-specific promotor. Optimal AdV transfection required 9-minute aortic occlusion, versus 5-minute occlusion for AAV. Using this method, we examined the in vivo function of phospholamban (PLB) by stably transfecting PLB-null mice with AAV encoding PLB (AAV(PLB)). AAV(PLB) restored PLB protein to near control levels that colocalized with SERCA2A in cardiomyocytes. At baseline, PLB-null hearts exhibited enhanced systolic and diastolic function, but frequency-dependent reserve was blunted versus wild-type controls. These properties, particularly the frequency response, returned toward control 3 months after AAV(PLB) transfection.The new simplified approach for murine whole-heart viral transfection should assist molecular physiology studies.
Pregnancy order and reproductive loss.
Authors: W H James
Journal: BMJ (1980)

This is a comment on a paper by Bakketeig and Hoffman which appeared previously in this journal. The paper dealt with pregnancy order and reproductive loss. Evidently, other comment has also been elicited. The original writers and all those commenting agree that the probability of engaging in a further pregnancy may be affected by the outcome of the previous pregnancy. Reproductive compensation may occur in the case of still births, perinatal death, neonatal death, and spontaneous abortion at some maternal ages and some birth orders and not at others.