tbuckley/cabot-search huggingface dataset:
Letter by Toska Regarding Article, “Biological Basis of Therapeutic Lymphangiogenesis”
Authors: Karin Toska
Journal: Circulation (2011)

In the introduction of their otherwise excellent review, "Biological Basis of Therapeutic Lymphangiogenesis," Norrme ´n et al seem to present an outdated view on fluid balance in the microcirculation. 1 I agree with the authors that, "The pumping force of the heart generates a hydrostatic pressure, which pushes fluid out of the semipermeable blood capillaries into the interstitial space."However, I believe that their next statement, "Most of the extravasated interstitial fluid is absorbed back by colloid osmotic pressure into the blood capillaries on the venous side of the capillary bed" is not a correct representation of the state of the art knowledge as of 2011.The authors do cite one of the experts in the field, J Rodney Levick, but, in fact, he provides convincing data refuting their view.The very first sentence in the cited book chapter runs, "Water and solutes are continuously passing out of the vascular circulation across the walls of capillaries and venules into the interstitial compartment, where they maintain the 'milieu inte ´rieur' of the tissue." 2 In a recent review, Levick and Michel explicitly state, "Sum-of-forces evidence and direct observations show that microvascular absorption is transient in most tissues; slight filtration prevails in the steady state, even in venules." 3 The review covers very convincingly the current experimental evidence for this.In specialized tissue, where fluid is absorbed, and transiently after vasoconstriction, considerable fluid absorption does take place through capillaries and venules, but this is not the normal steady-state situation.
Effect of Pretreatment of Food Gluten With Prolyl Endopeptidase on Gluten-Induced Malabsorption in Celiac Sprue
Authors: Gail G. Pyle, Brian Paaso, Barbara E. Anderson, Diane D. Allen, Thomas Marti, Qing Li, Matthew Siegel, Chaitan Khosla, Gary M. Gray
Journal: Clinical Gastroenterology and Hepatology (2005)
Unusual Patterns of Crime During<i>La Violencia</i>in Colombia
Authors: CARLOS A. LEON
Journal: American Journal of Psychiatry (1969)

After describing the atrocious crimes characteristic of the period known as La Violencia in Colombia, the author presents a formulation about the psychological factors that may have contributed to their commission. The early background of the bandolero criminal type characteristically included an atmosphere of social, economic, religious, and familial repression. When a state of social and political unrest arose in the country, bringing about the collapse of the traditional repressive forces, a chain of psychological developments was begun that culminated in the unleashing of intense destructive rage.
TREATMENT OF CHRONIC SCHIZOPHRENICS WITH LIOTHYRONINE (L-TRIIODOTHYRONINE)
Authors: E. J. TOLAN, B. KOVITZ, LOWELL DILLON
Journal: American Journal of Psychiatry (1960)

Half of the group of 24 showed temporary changes. These changes were maximal at the peak doses, either in the direction of decreased depression and withdrawal (8 cases) or increased restlessness and tension (4 cases). These changes were not lasting, and as the medication was decreased, the group as a whole returned to its original level. The temporary periods of improvement occurred in a peculiar cyclic pattern, lasting from a few days to a few weeks at a time. In higher doses the drug was accompanied by changes in the mood and activity of chronic schizophrenic patients, but did not bring about a lasting or dependable improvement in psychiatric status or hospital adjustment. The use of liothyronine in psychiatric disorders must still be considered in experimental stage.
The Second Look: The Reconstruction of Personal History in Psychiatry and Psychoanalysis
Authors: Martin Grotjahn
Journal: JAMA (1968)

In the therapeutic confrontation, the patient and therapist reconstruct a history that creates meaningful relationships between the past and present. In this book, Dr. Novey conducts a search into the authenticity of autobiographical data. He believes that historical data are of great value but are not valid if they are used as evidence for what "actually happened." He investigates the philosophy of history and ventures into the reliability of anamnestic reports, neurophysiological experiments, memory, legal knowledge, the validity of evidence, and psychoanalytic theory. Dr. Novey discusses methods by which the reconstruction of history underscores the living nature of history in the therapeutic process. He believes that "having a second look" at the past could modify a person's view of his past and thereby modify the course of his future; his book represents an effort to reassert the importance of history in the treatment process and in the patient's understanding of
Dysfunction of the Diaphragm
Authors: F. Dennis McCool, George E. Tzelepis
Journal: New England Journal of Medicine (2012)

Dysfunction of one or both hemidiaphragms is an underdiagnosed cause of dyspnea. Weakness or paralysis may be seen during mechanical ventilation, after surgery or trauma, with metabolic or inflammatory disorders, and with myopathy, neuropathy, or diseases causing lung hyperinflation.
The Role of Radionuclide Bone Scintigraphy in Fibrous Dysplasia of Bone
Authors: Yuan Zhibin, Luo Quanyong, Chen Libo, Zhu Jun, Lu Hankui, Zhu Jifang, Zhu Ruisen
Journal: Clinical Nuclear Medicine (2004)

Purpose: The purpose of this study was to study the characteristics of fibrous dysplasia (FD) of bone on bone scans and to evaluate the diagnostic value of radionuclide bone scans in FD. Methods: Radionuclide bone scans were performed in 42 cases of histopathologically proven FD and the results were compared with other imaging modalities. A retrospective study method was used to analyze the imaging results. Results: Although FD showed nonspecific increased 99m-Tc MDP uptake, its appearance is different than bone metastates and other bone diseases. Combining scans with x-rays and other imaging modalities can improve the diagnostic accuracy of this disease. Conclusions: Radionuclide bone scans are of certain value in the diagnosis of FD. The diagnostic specificity of FD with radionuclide bone scanning can be improved in association with other imaging modalities such as x-rays.
Evidence for Association and Genetic Linkage of the Angiotensin-Converting Enzyme Locus With Hypertension and Blood Pressure in Men but Not Women in the Framingham Heart Study
Authors: Christopher J. O’Donnell, Klaus Lindpaintner, Martin G. Larson, Valluri S. Rao, Jose M. Ordovas, Ernst J. Schaefer, Richard H. Myers, Daniel Levy
Journal: Circulation (1998)

Background —There is controversy regarding the association of the angiotensin-converting enzyme deletion-insertion ( ACE D/I ) polymorphism with systemic hypertension and with blood pressure. We investigated these relations in a large population-based sample of men and women by using association and linkage analyses. Methods and Results —The study sample consisted of 3095 participants in the Framingham Heart Study. Blood pressure measurements were obtained at regular examinations. The ACE D/I polymorphism was identified by using a polymerase chain reaction assay. In logistic regression analysis, the adjusted odds ratios for hypertension among men for the DD and DI genotypes were 1.59 (95% confidence interval [CI], 1.13 to 2.23) and 1.18 (95% CI, 0.87 to 1.62), respectively, versus II (χ 2 P =.02). In women, adjusted odds ratios for the DD and DI genotypes were 1.00 (95% CI, 0.70 to 1.44) and 0.78 (95% CI, 0.56 to 1.09), respectively ( P =.14). In linear regression analysis, there was an association of the ACE DD genotype with increased diastolic blood pressure in men (age-adjusted P =.03, multivariate-adjusted P =.14) but not women. Quantitative trait linkage analyses in 1044 pairs of siblings, by using both ACE D/I and a nearby microsatellite polymorphism of the human growth hormone gene, supported a role of the ACE locus in influencing blood pressure in men but not in women. Conclusions —In our large, population-based sample, there is evidence for association and genetic linkage of the ACE locus with hypertension and with diastolic blood pressure in men but not women. Our data support the hypothesis that ACE , or a nearby gene, is a sex-specific candidate gene for hypertension. Confirmatory studies in other large population-based samples are warranted.
Esophagitis Associated with Esophageal Hiatal Hernias
Authors: Fletcher A. Miller, Henrique Neto, Robert Sellers
Journal: JAMA (1963)

THIS ESSAY is premised on the hypothesis that present, commonly accepted techniques for surgical correction of esophageal hiatal hernias too often are inadequate. Generally speaking, the structural design of the esophagus is ideal for the ordinary physiological conduit demands. However, transmission of extremes of chemical composition which result in a radically altered pH is very poorly tolerated. Everyone is keenly aware of the disability which follows ingestion of strong acids or alkalis, but naturally-occuring, altered anatomical and physiological states probably claim an even greater number of victims than these self-inflicted hand-to-mouth lesions. While the nature of the prevention of the autodigestion of the stomach itself is still far from solved, it can be readily demonstrated that both inlet and outlet of the stomach have been designed to prevent repeated chemical insults from the digestive reservoir. Continuous pH recordings over a 24-hr period reveal that under normal conditions there are very
Absence of SKP2 expression attenuates BCR-ABL–induced myeloproliferative disease
Authors: Anupriya Agarwal, Thomas G. P. Bumm, Amie S. Corbin, Thomas O'Hare, Marc Loriaux, Jonathan VanDyke, Stephanie G. Willis, Jutta Deininger, Keiichi I. Nakayama, Brian J. Druker, Michael W. Deininger
Journal: Blood (2008)
Stimulation of protein synthesis and breakdown by vaccination.
Authors: P J Garlick, M A McNurlan, E B Fern, A M Tomkins, J C Waterlow
Journal: BMJ (1980)

Six normal volunteers were vaccinated against typhoid-cholera. 15N-Glycine was injected the morning after vaccination. The injection was repeated three to six days and 10 days later. All subjects ate the same diet on each occasion. Excretion of 15N in urinary ammonia and total urinary excretion of nitrogen, ammonia, and creatinine were determined after each injection of isotope. Urinary excretion of 15N was used to calculate rates of whole-body protein turnover. Total urinary nitrogen and ammonia excretions showed no appreciable change on all three days. Creatinine excretion was significantly higher the day after vaccination than on the other two days (p < 0.05). Rates of protein turnover were also significantly higher on this day: a 37% increase in synthesis and 55% increase in degradation were noted. These results show that during the reaction to vaccination there was a stimulation of whole-body protein metabolism that is similar to that produced by sepsis.
Infectious Mononucleosis in Asymptomatic Hodgkin Disease
Authors: Samir K. Ballas, Parvin Saidi, Peter Felix Coccia
Journal: JAMA (1975)

HODGKIN disease and infectious mononucleosis have long been recognized to be associated with each other. There are at least 37 patients reported in the literature<sup>1</sup>in whom infectious mononucleosis was well documented before the onset of Hodgkin disease. Moreover, in two patients, Hodgkin disease and infectious mononucleosis were diagnosed concurrently.<sup>2,3</sup>We report here a further example of the association of these two diseases. Our patient, however, is paradoxical in comparison to those previously reported, in that Hodgkin disease preceded the onset of infectious mononucleosis. <h3>Report of a Case</h3> A 20-year-old woman was well until about three months prior to her first admission to Raritan Valley Hospital on Feb 20, 1974, when a slightly tender swelling of the right side of the neck was noted with no other signs or symptoms. There was no past history or family history of any blood dyscrasia. Chronic drug use or abuse was denied.
Pregnancy-Related Thromboembolism
Authors: Martin H. Prins
Journal: Annals of Internal Medicine (1997)

Letters15 July 1997Pregnancy-Related ThromboembolismMartin H. Prins, MD, PhDMartin H. Prins, MD, PhDAcademic Medical Center, University of Amsterdam; Amsterdam, the NetherlandsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-2-199707150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Manoharan addresses the important issue of the use of a drug when there is no formal knowledge of safety in a specific situation. The experience with low-molecular-weight heparin in pregnancy was obtained while the pharmaceutical companies advised against use of the drug during pregnancy [1, 2]. One report has indicated that low-molecular-weight heparin, like unfractionated heparin, does not appear in breast milk [3]. Moreover, heparin is not easily absorbed and thus when given orally is unlikely to cause any adverse effects.We thank Brickner and colleagues for pointing out a mathematical error that escaped our attention when ...References1. Rasmussen C, Wadt J, Jacobsen B. Thromboembolic prophylaxis with LMWH during pregnancy. Int J Gynecol Obstet. 1994; 47:121-5. Google Scholar2. Melissari E, Parker CJ, Wilson NV, et al. Use of LMWH in pregnancy. Thromb Haemost. 1992; 68:652-6. Google Scholar3. Harenberg J, Leber G, Zimmermann R, Schmidt W. Thromboembolieprophylaxe mit niedermolekularem Heparin in der Schwangerschaft. Geburtsh u Frauenheilk. 1987:47:15-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Academic Medical Center, University of Amsterdam; Amsterdam, the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1997Volume 127, Issue 2Page: 164KeywordsBreast milkDrug safetyDrugsHeparinLow molecular weight heparinPregnancySafetyThromboembolismVenous thromboembolism Issue Published: 15 July 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
How to manage Waldenstrom’s macroglobulinemia
Authors: C Buske, V Leblond
Journal: Leukemia (2013)

Waldenstrom's macroglobulinemia (WM) is very distinct from other indolent lymphoma subtypes: by definition it is accompanied by a monoclonal IgM gammopathy; it presents always with bone marrow infiltration and often with clinical symptoms such as neuropathy or hyperviscosity. These disease characteristics and the frequently advanced age of the WM patient pose a major challenge to the treating clinician even today. Recently, there has been not only substantial progress in our understanding of the biology of WM, but we have also significantly improved our tools to prognostify and to treat patients with this disease. This review summarizes our current knowledge about WM and aims at offering a guideline for the clinical management of patients with this lymphoma subtype, covering questions on how to manage diagnosis, prognostification and treatment based on the most recent data.
Function of Potential Bypass Tracts for Atrioventricular Conduction
Authors: TOYOMI SANO, FUMIO SUZUKI, HIROMICHI TSUCHIHASHI
Journal: Circulation (1970)

Function of potential bypass tracts for the atrioventricular conduction was examined in isolated rabbit hearts using microelectrodes, a suction electrode, and bipolar electrocardiographic leads. After the normal A-V conduction was blocked by acetylcholine, conduction to the ventricle occurred with a much shorter A-V conduction time and without significant QRS change, when a point at the root of the inferior vena cava was stimulated. By analyzing the site of delay, this route was presumed to go from the right atrium to the lower portion of the His bundle bypassing the A-V node. When a point inferior to this point was stimulated, marked shortening of conduction time and marked QRS change occurred. This second tract seemed to exist between the right atrium and ventricle bypassing the specialized system. The third tract was found when an anterior point on the right atrium was stimulated. The conduction was markedly prolonged without changing the QRS. This route seemed to enter some point of the A-V node, inducing a detour within the node.
Beta Adrenergic Blockade and the Phantom Limb
Authors: WILLIAM A. OILLE
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 December 1970Beta Adrenergic Blockade and the Phantom LimbWILLIAM A. OILLE, M.D., F.R.C.P.(C), F.A.C.P.WILLIAM A. OILLE, M.D., F.R.C.P.(C), F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-6-1044_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: My patient was 74 years old when first seen in 1958. He had reached the peak of the legal profession in his province and was an active naturalist and sportsman. A year previously he had been involved in a minor accident and from that date on had suffered mild but typical angina. His electrocardiogram indicated previous inferior wall infarction.At 12 years of age an accidental shotgun blast led to amputation of the right arm, which left him with a 3-in. stump at the shoulder. From that date he suffered spasmodic, severe phantom-limb pain. He has been... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Toronto Toronto General Hospital PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPhantom Limb Pain—A Complication of Lower Extremity Wound ManagementAcquired limb deficiencies. 4. TroubleshootingDifferentiation and Treatment of Phantom Sensation, Phantom Pain, and Residual-Limb PainClonazepam for the Treatment of Lancinating Phantom Limb PainPostamputation Phantoms: A ReviewPhantom Limb Pain. A ReviewClinical pharmacology of the new betaadrenergic blocking drugs. Part 13. The betaadrenoceptor blocking drugs: A perspectiveDrug Information Analysis ServicePropranololHOWARD F. MORRELLI, M.D., F.A.C.P. 1 December 1970Volume 73, Issue 6Page: 1044-1045KeywordsAnginaElectrocardiographyFirearm injuriesInfarctionShoulders Issue Published: 1 December 1970 PDF DownloadLoading ...
Convalescence After Herniorrhaphy
Authors: Irving L. Lichtenstein
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Certainly I agree with Kerry that all inguinal hernias should be repaired before participation in school athletic programs. However, his statement that "(after operation) activity too early is likely to cause undue strain on the hernia repair and thereby increase the possibility of recurrence" is open to scrutiny. Our work (<i>Surg Gynec Obstet</i><b>130</b>:685, 1970) demonstrates that, during the first eight weeks after operation, wound healing does not contribute to the strength of the sutured wound. A healing wound acquires only 40% of intact tissue strength from wound healing by two months. The same structures, repaired with strong nonabsorbable suture, achieve 70% of intact tissue strength immediately; this is maintained throughout the next two months, exceeding at all times the tensile strength attributable to the healing process. The quality of the approximated aponeurotic tissue and the strength of the suture material are the factors determining the
Effect of Trimethoprim on Lamivudine Bioavailability-Reply
Authors: Christine Katlama
Journal: JAMA (1996)

In Reply.  —Trimethoprim increases the lamivudine area-under-the-curve (AUC) because of competition for renal excretion through the organic cationic transport system in the kidneys. While it is tempting to consider lower doses of lamivudine in combination with trimethoprim to reduce the cost of antiretroviral regimens, this approach is inappropriate because the bioavailability of lamivudine has a high interpatient variability (mean, 86%; range, 53%-105%), 1 and the interpatient variability for the lamivudine AUC when it is administered with trimethoprim-sulfamethoxazole is also high at 44% (SD, 23%). 2   Monitoring blood levels of lamivudine to ensure adequate exposure to the drug would outweigh the benefits of a simple oral dosing regimen. Moreover, the clearance of other medications that are renally excreted by the organic cationic transport system would be affected by the routine use of trimethoprim to enhance lamivudine levels. While the increased blood levels of lamivudine are not associated with any increased risk of adverse
Degree of Preservation of the Neurovascular Bundles During Radical Prostatectomy and Urinary Continence 1 Year after Surgery
Authors: Gunnar Steineck, Anders Bjartell, Jonas Hugosson, Elin Axén, Stefan Carlsson, Johan Stranne, Anna Wallerstedt, Josefin Persson, Ulrica Wilderäng, Thordis Thorsteinsdottir, Ove Gustafsson, Mikael Lagerkvist, Thomas Jiborn, Eva Haglind, Peter Wiklund
Journal: European Urology (2014)
Herpes simplex virus-specific immune responses in subjects with frequent and infrequent orofacial recrudescences
Authors: D.B. Mckenna, W.A. Neill, M. Norval
Journal: British Journal of Dermatology (2001)

Background Following the primary infection of the orofacial region with herpes simplex virus (HSV) type 1, the virus remains latent in the ganglia for the lifetime of the host but can reactivate at intervals and cause recrudescent lesions. The frequency of these episodes varies considerably from one individual to another. Objectives To compare immune responses in two groups of subjects: those with frequent orofacial lesions, defined as 10 or more per year (n = 12), and those with infrequent lesions, defined as three or fewer per year (n = 20). Methods Plasma and peripheral blood mononuclear cells were collected from each individual for the series of immunological tests listed in the following results section. Results Although IgG titres specific for HSV, measured by enzyme-linked immunosorbent assay (ELISA), were not different between the two groups, there was a significantly higher HSV-specific IgE titre in the frequent group. The percentages of CD3-, CD4- and CD8-positive cells in peripheral blood, assessed by flow cytometry, and the in vitro lymphoproliferative response to the non-specific mitogen concanavalin A, did not differ between the two groups. T-cell responses to HSV were assessed by in vitro lymphoproliferation with tritiated thymidine incorporation and subsequent calculation of the stimulation index; cytokine production [interferon (IFN)-γ and interleukin (IL)-10] into the culture supernatant as a result of the stimulation was measured by ELISAs. The mean ± SEM stimulation index was 4·1 ± 0·2 in the subjects with frequent lesions and 11·8 ± 3·1 in the subjects with infrequent lesions, a difference that was significant. The mean IL-10 concentrations found in the subjects with frequent and infrequent lesions were 154 and 110 pg mL−1, respectively, a difference that did not reach significance. However, the IFN-γ production was significantly lower in the subjects with frequent lesions compared with those with infrequent lesions: mean 835 and 1679 pg mL−1, respectively. Conclusions Thus, from the HSV-specific T-cell proliferation, IFN-γ production and IgE results, patients who experience frequent recrudescences may tend towards the production of T-helper 2 cytokines in response to the virus, which may lead, in turn, to less effective control of viral replication in the periphery following reactivation from latency.