tbuckley/cabot-search huggingface dataset:
A piece of my mind. A conversation with my mother
Authors: D. M. Eddy
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial Aggregation of Lone Atrial Fibrillation in Young Persons
Authors: Nina Øyen, Mattis F. Ranthe, Lisbeth Carstensen, Heather A. Boyd, Morten S. Olesen, Søren-Peter Olesen, Jan Wohlfahrt, Mads Melbye
Journal: Journal of the American College of Cardiology (2012)
An affinity/avidity model of peripheral T cell regulation
Authors: Hong Jiang, Yilun Wu, Bitao Liang, Zongyu Zheng, Guomei Tang, Jean Kanellopoulos, Mark Soloski, Robert Winchester, Itamar Goldstein, Leonard Chess
Journal: Journal of Clinical Investigation (2005)

We show in these studies that Qa-1–dependent CD8+ T cells are involved in the establishment and maintenance of peripheral self tolerance as well as facilitating affinity maturation of CD4+ T cells responding to foreign antigen. We provide experimental evidence that the strategy used by the Qa-1–dependent CD8+ T cells to accomplish both these tasks in vivo is to selectively downregulate T cell clones that respond to both self and foreign antigens with intermediate, not high or low, affinity/avidity. Thus, the immune system evolved to regulate peripheral immunity using a unified mechanism that efficiently and effectively permits the system to safeguard peripheral self tolerance yet promote the capacity to deal with foreign invaders.
Emerging trends in candidemia: A higher incidence but a similar outcome
Authors: J. Fortún, P. Martín-Dávila, E. Gómez-García de la Pedrosa, V. Pintado, J. Cobo, G. Fresco, Y. Meije, L. Ros, M.E. Alvarez, J. Luengo, M. Agundez, A. Belso, A. Sánchez-Sousa, E. Loza, S. Moreno
Journal: Journal of Infection (2012)
A Study of the Combined Effects of Physical Activity and Air Pollution on Mortality in Elderly Urban Residents: The Danish Diet, Cancer, and Health Cohort
Authors: Zorana Jovanovic Andersen, Audrey de Nazelle, Michelle Ann Mendez, Judith Garcia-Aymerich, Ole Hertel, Anne Tjønneland, Kim Overvad, Ole Raaschou-Nielsen, Mark J. Nieuwenhuijsen
Journal: Environmental Health Perspectives (2015)

Physical activity reduces, whereas exposure to air pollution increases, the risk of premature mortality. Physical activity amplifies respiratory uptake and deposition of air pollutants in the lung, which may augment acute harmful effects of air pollution during exercise.We aimed to examine whether benefits of physical activity on mortality are moderated by long-term exposure to high air pollution levels in an urban setting.A total of 52,061 subjects (50-65 years of age) from the Danish Diet, Cancer, and Health cohort, living in Aarhus and Copenhagen, reported data on physical activity in 1993-1997 and were followed until 2010. High exposure to air pollution was defined as the upper 25th percentile of modeled nitrogen dioxide (NO2) levels at residential addresses. We associated participation in sports, cycling, gardening, and walking with total and cause-specific mortality by Cox regression, and introduced NO2 as an interaction term.In total, 5,534 subjects died: 2,864 from cancer, 1,285 from cardiovascular disease, 354 from respiratory disease, and 122 from diabetes. Significant inverse associations of participation in sports, cycling, and gardening with total, cardiovascular, and diabetes mortality were not modified by NO2. Reductions in respiratory mortality associated with cycling and gardening were more pronounced among participants with moderate/low NO2 [hazard ratio (HR) = 0.55; 95% CI: 0.42, 0.72 and 0.55; 95% CI: 0.41, 0.73, respectively] than with high NO2 exposure (HR = 0.77; 95% CI: 0.54, 1.11 and HR = 0.81; 95% CI: 0.55, 1.18, p-interaction = 0.09 and 0.02, respectively).In general, exposure to high levels of traffic-related air pollution did not modify associations, indicating beneficial effects of physical activity on mortality. These novel findings require replication in other study populations.
Stereotactic Body Radiation Therapy for Primary Lung Cancers &gt;3 Centimeters
Authors: John J. Cuaron, Ellen D. Yorke, Amanda Foster, Meier Hsu, Zhigang Zhang, Fan Liu, Andrew Jackson, Borys Mychalczak, Kenneth E. Rosenzweig, Abraham J. Wu, Andreas Rimner
Journal: Journal of Thoracic Oncology (2013)
Congenital heart disease and pulmonary artery hypertension. I. pulmonary vasoreactivity to 15% oxygen before and after surgery
Authors: J. Deane Waldman, John J. Lamberti, James W. Mathewson, Stanley E. Kirkpatrick, Searle Wm. Turner, Lily George, Stanley J. Pappelbaum
Journal: Journal of the American College of Cardiology (1983)
Abstract 4002: Functional investigation and identification of dephosphorylation targets of tumor-suppressive protein tyrosine phosphatase, PTPRG
Authors: Arthur KL Cheung, Hong Lok Lung, Josephine MY Ko, Joseph CY Ip, Eugene Zabarovsky, Eric J. Stanbridge, Maria L. Lung
Journal: Cancer Research (2012)

Abstract Background and aims: PTPRG was identified as a candidate tumor suppressor gene. It belongs to a family of membrane-bound receptor tyrosine phosphatases. However, the function and the dephosphorylation targets of PTPRG still remain to be elucidated. The aim of this current study was to identify the downstream dephosphorylation targets of PTPRG. Methods: A tetracycline-inducible system was used to obtain PTPRG-expressing clones. The dephosphorylation targets were identified by an antibody array. The anti-angiogenesis function of PTPRG was investigated by HUVEC tube formation assay. Results: The c-jun phosphorylation level was found to be down-regulated after re-expression of PTPRG. Re-expression of PTPRG can inhibit tube formation in the HUVEC tube formation assay by down-regulating the AP1 downstream target, VEGF, secretion. Conclusions: Re-expression of PTPRG can reduce the phosphorylation of c-jun and, thus, inhibit angiogenesis by down-regulating the important angiogenesis regulator, VEGF. The results suggest the importance of PTPRG in regulating tumor formation. It is a good candidate tumor suppressor gene, which warrants further study. Acknowledgements: This work was supported by the Research Grants Council and the University Grants Council of the Hong Kong Special Administrative Region, People's Republic of China (AoE/M-06/08, to M.L.L.) and the University of Hong Kong Small Project Fund (Grant 200907176081, to A.K.L.C.). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4002. doi:1538-7445.AM2012-4002
The Healthcare Innovation Zone
Authors: Darrell G. Kirch
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Integrated care is what we all want
Authors: F. Godlee
Journal: BMJ (2012)

Integrated care is one of those concepts that’s hard to argue against. Who among us would not want hospital staff to work closely with primary, community, and social care services, so that, when we turn up in the emergency department with a serious exacerbation of our chronic condition, the team there knows all about us? Better still, wouldn’t we all want the various teams to liaise closely so we don’t have to go to hospital at all? If, by integrated care, we mean seamless, high quality care, it’s obviously desirable. So why is it so hard to achieve? And why do we struggle to deliver it in the …
The joy of discovery
Authors: Parveen Kumar
Journal: BMJ (2006)

I find it hard to look back and capture what initially inspired me to take up medicine, but I think that my aspirations are still the same. Medicine is a “way of life” and combines that rather nebulous feeling of wanting to help and care with the more exact principles of science and logical thought. After all these years as a doctor, I still want to get out of bed and go to work in the mornings. Despite all the cutbacks, targets, organisational problems, and increasing workload in the National Health Service, the patients are still there. Doctors are at the top of the list of professions that the public thinks are worthy of “respect” and also are “most likely to tell the truth,” and this makes me feel privileged to be a doctor. There is no place for arrogance or self satisfaction—the days of Sir Lancelot Spratt are hopefully far gone. 

Clinical medicine still holds many challenges. Although many clinical problems are easily diagnosed I still relish a diagnostic conundrum that calls …
Pharmacological Profile of KP-496, a Novel Dual Antagonist for Cysteinyl Leukotriene Receptor (CysLT1R) and Thromboxane A2 Receptor (TP)
Authors: M. Ishimura, M. Suda, S. Kataoka, T. Maeda, Y. Hiyama
Journal: Journal of Allergy and Clinical Immunology (2006)
Concreted Cornhusker Sent Back to Loam, Sweet Loam. Aw Shucks!-Reply
Authors: Elizabeth Knoll
Journal: JAMA (1987)

<h3>In Reply.—</h3> Drs Howard and Young are, of course, entirely right about my muddled corn terminology. The error is all the more embarrassing because my roots<i>are</i>in loam: I am a native of Nebraska. Although I did not grow up on a farm, I certainly know the difference between corn husks, ears of corn, and corn cobs. My family's discovery that I was capable of such an elementary goof will only confirm their view that my education was seriously marred by my neglect of Cornhusker football games and other patriotically instructive rituals. Fortunately, my mother has reassured me that I will still be allowed to come home for Christmas. One can't argue with Dr Young's suggestion that the elderly man in the painting could be the little boy's father: this is not a portrait of real individuals, after all. That we who are several generations removed from 19th-century rural
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans
Authors: Guangyu An, Bo Wei, Baoyun Xia, J. Michael McDaniel, Tongzhong Ju, Richard D. Cummings, Jonathan Braun, Lijun Xia
Journal: The Journal of Experimental Medicine (2007)

Altered intestinal O-glycan expression has been observed in patients with ulcerative colitis and colorectal cancer, but the role of this alteration in the etiology of these diseases is unknown. O-glycans in mucin core proteins are the predominant components of the intestinal mucus, which comprises part of the intestinal mucosal barrier. Core 3–derived O-glycans, which are one of the major types of O-glycans, are primarily expressed in the colon. To investigate the biological function of core 3–derived O-glycans, we engineered mice lacking core 3 β1,3-N-acetylglucosaminyltransferase (C3GnT), an enzyme predicted to be important in the synthesis of core 3–derived O-glycans. Disruption of the C3GnT gene eliminated core 3–derived O-glycans. C3GnT-deficient mice displayed a discrete, colon-specific reduction in Muc2 protein and increased permeability of the intestinal barrier. Moreover, these mice were highly susceptible to experimental triggers of colitis and colorectal adenocarcinoma. These data reveal a requirement for core 3–derived O-glycans in resistance to colonic disease.
Metastasis of Hepatocellular Carcinoma to the Colon Demonstrated by Tc-99m PMT Scintigraphy
Authors: HIROYUKI FUKUI, TORU KASHIWAGI, YASUHIRO SHIRAI, YUKIHIKO MATSUDA, SUMIO KAWATA, TSUNEHIKO NISHIMURA, TAKAHIRO KOZUKA
Journal: Clinical Nuclear Medicine (1993)

A 57-year-old man was found to have a tumor in the ascending colon after hepatic segmentectomy for ruptured hepatocellular carcinoma. Colonoscopy was performed, and metastasis of the hepatocellular carcinoma to the ascending colon was suspected based on the biopsy specimens obtained from the tumor. On hepatobiliary scintigraphy using Tc-99m PMT performed to confirm this diagnosis, Tc-99m PMT was clearly observed to accumulate in the tumor. Thus, the tumor was diagnosed as metastasis of hepatocellular carcinoma.
Trephine biopsy for diffuse lung lesions.
Authors: S. J. Steel, D. P. Winstanley
Journal: BMJ (1967)

DiscussionThere has been an increase recently in the use of L.S.D. in this country on a casual basis and not under medical supervision.Use in this way as a "mind-expanding" drug has been extensively discussed in the press and on television, and has been advocated in non-medical journals.After a similar interest in the non-medical uses of the drug and extensive self-medication by fringe groups in New York therc was a sudden upsurge of admissions to Bellevue Hospital with acute reactions from its use (Frosch et al., 1965).These fell into three groups: (1) acute panic reactions; (2) recurrence of symptoms while abstaining from the drug, which was more likely to occur after multiple ingestion; and (3) prolonged psychosis.Cases 1, 2, and 5 reported here appeared to be acute panic reactions, and Cases 3 and 4 a recurrence of symptoms in a period of abstinence.Case 4 also showed signs of a prolonged psychosis.Case 6 may have been due to disordered judge- ment or a psychotic reaction.Prolonged adverse reactions, including chronic hallucinatory states, also occur (Rosenthal, 1964).Owing to the fashion of using sugar cubes as a vehicle for black market L.S.D. it can also be taken accidentally-for example, by children-and three such cases have been reported.One of these sustained a dissociative state, accom- panied by anxiety and visual illusions, that lasted for several weeks (Cohen, 1966).Cases 5 and 6 show the need to look for L.S.D. and amphetamines at necropsy in deaths of this type, lest some be wrongly attributed to suicide.Despite the statements of the protagonists of the use of this drug that it is safe, L.S.D. can be dangerous when taken casually-for example, when not taken by selected patients under strict medical supervision and with the use of proper safeguards.The incidence of adverse effects associated with controlled use of the drug by physicians suggested that in medical hands it was an exceptionally safe drug (Levine and Ludwig, 1964). SummaryRecently there has been an increase in the use of lysergide (lysergic acid diethylamide; L.S.D.) obtained illicitly.Adverse reactions are not uncommon, and six (two fatal) cases are reported.I am grateful to Professor F. E. Camps, Dr. A. Robinson, and Mr. F. F
A NOTE ON THE FILTRATION OF THE VIRUS OF HERPETIC ENCEPHALITIS AND OF VACCINIA
Authors: Hugh K. Ward, Fei-Fang Tang
Journal: The Journal of Experimental Medicine (1929)

The virus of herpetic encephalitis and the virus of vaccinia can be demonstrated in the filtrate, if a broth emulsion of fresh tissue containing the virus, is passed through a Berkefeld V filter.
TCT-344 Importance of Optimal Reperfusion in Diabetic Patients Treated with Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction
Authors: M.A. Velders, H. Boden, B.L. van der Hoeven, A.A.C.M. Heestermans, V.A.W.M. Umans, S.H. Hofma, J.W. Jukema, M.J. Schalij, A.J. van Boven
Journal: Journal of the American College of Cardiology (2012)
Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children's Oncology Group Study AALL0031
Authors: K R Schultz, A Carroll, N A Heerema, W P Bowman, A Aledo, W B Slayton, H Sather, M Devidas, H W Zheng, S M Davies, P S Gaynon, M Trigg, R Rutledge, D Jorstad, N Winick, M J Borowitz, S P Hunger, W L Carroll, B Camitta
Journal: Leukemia (2014)
Medical Intensive Care for the Elderly
Authors: Edward W. Campion
Journal: JAMA (1981)

All admissions (2,693) to a medical intensive and coronary care unit (ICU/CCU) during a two-year period were reviewed to compare indications for admission, major interventions, and outcomes for elderly patients with those for younger patients. Once admitted to the ICU/CCU, older patients were more likely to receive major life-support interventions such as mechanical ventilation but less likely to survive. Major interventions were used in 32% of patients aged 75 years or older, in 26% of those 65 to 74 years, and in 22% of those 55 to 64 years. Nonetheless, elderly patients had no longer mean lengths of stay and no greater mean hospital charges. Hospital mortality for the oldest patients was 16%, compared with 14% and 8% for the younger age groups. Cumulative mortality one year after discharge for those older than 75 years was 44%. Elderly hospital survivors returned to their preadmission living situation but did not regain their preadmission activity level.
Book Review Physicians' Desk Reference (PDR) Library on CD-ROM CD-ROM with installation diskette (3.5߱) and manual. Montvale, N.J., Medical Economics Data, 1994. System needed: IBM PC or compatible, with DOS 3.1 or higher and at least 640 kilobytes of RAM. PDR library $595 (single user); PDR library plus Merck Manual $895 (single user).
Authors: Eytan Blumenthal, Daniel Mimouni
Journal: New England Journal of Medicine (1995)
IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation
Authors: Erwan Mortier, Tammy Woo, Rommel Advincula, Sara Gozalo, Averil Ma
Journal: The Journal of Experimental Medicine (2008)

Natural killer (NK) cells are innate immune effectors that mediate rapid responses to viral antigens. Interleukin (IL)-15 and its high affinity IL-15 receptor, IL-15Ralpha, support NK cell homeostasis in resting animals via a novel trans presentation mechanism. To better understand how IL-15 and IL-15Ralpha support NK cell activation during immune responses, we have used sensitive assays for detecting native IL-15 and IL-15Ralpha proteins and developed an assay for detecting complexes of these proteins. We find that IL-15 and IL-15Ralpha are preassembled in complexes within the endoplasmic reticulum/Golgi of stimulated dendritic cells (DCs) before being released from cells. IL-15Ralpha is required for IL-15 production by DCs, and IL-15 that emerges onto the cell surface of matured DCs does not bind to neighboring cells expressing IL-15Ralpha. We also find that soluble IL-15-IL-15Ralpha complexes are induced during inflammation, but membrane-bound IL-15-IL-15Ralpha complexes, rather than soluble complexes, support NK cell activation in vitro and in vivo. Finally, we provide in vivo evidence that expression of IL-15Ralpha specifically on DCs is critical for trans presenting IL-15 and activating NK cells. These studies define an unprecedented cytokine-receptor biosynthetic pathway in which IL-15Ralpha serves as a chaperone for IL-15, after which membrane-bound IL-15Ralpha-IL-15 complexes activate NK cells via direct cell-cell contact.
Flat Adenomas in the United Kingdom: Are Treatable Cancers Being Missed?
Authors: T. Fujii, B. J. Rembacken, M. F. Dixon, S. Yoshida, A. T. R. Axon
Journal: Endoscopy (1998)

Background and Study Aims: The recognized pathway for colorectal malignancies is the adenoma-carcinoma sequence. It is estimated that up to two-thirds of colorectal carcinomas arise from adenomatous polyps. In recent years, Japanese workers have suggested that early colorectal malignancies may arise as "flat" or "depressed" rather than as polypoid lesions. Such flat or depressed adenomas and adenocarcinomas have not been widely recognized in the West. A prospective study was carried out to search for flat and depressed adenomas in a British population, using Japanese colonoscopic techniques.
Alexithymia and the Split Brain
Authors: W.D. TenHouten, K.D. Hoppe, J.E. Bogen, D.O. Walter
Journal: Psychotherapy and Psychosomatics (1985)

8 commissurotomy patients and 8 precision-matched normal control subjects were shown a 3-min videotaped film about death. Content analysis of the subjects' spoken and written responses to this film was carried out on the global, interpretive level, for 2 fantasy and 4 symbolization variables. Commissurotomy patients were found to be significantly more alexithymic than normal controls for 3 of the symbolization variables, for factor-analytic measures of fantasy and symbolization, and for an over-all measure of alexithymia derived from these 2 factors and lexical-level and sentential-level measures of alexithymia.
THE VIABILITY OF TYPHOID BACILLI IN SHELL OYSTERS
Authors: EDWIN O. JORDAN
Journal: JAMA (1925)

Although the epidemiologic evidence is quite conclusive that oysters grown or "floated" in contaminated waters may sometimes be the vehicle of typhoid infection,<sup>1</sup>there appear to be relatively few observations on the duration of life of typhoid bacilli in shell oysters under the ordinary conditions of shipment and storage. Foote,<sup>2</sup>who injected shell oysters with 1 c.c. of a broth culture and kept them at a temperature of from 50 to 65 F., found typhoid bacilli in the "juice" and in the stomach after thirty days. Herdman and Boyce,<sup>3</sup>using the better method of floating the oysters in water to which typhoid bacilli were added, showed the presence of the bacilli in stored shell oysters "up to ten days." Field,<sup>4</sup>after carrying on similar investigations, concluded that when the oysters were removed from the infected tank and kept either directly on ice or else in a
789-5 Use of Rest Tomoscintigraphy with a Methylated Labelled Free Fatty Acid to Detect Myocardial Viability After Myocardial Infarction in Areas with Irreversible Defects on Exercise Single-Photon Emission-Computed Tomography-Tl201 with Rest-Reinjection
Authors: Michaël Angioï, Pierre-Yves Marie, Nicolas Danchin, Pierre Olivier, Gilles Karcher, Yves Juillière, Alain Bertrand, François Cherrier
Journal: Journal of the American College of Cardiology (1995)