tbuckley/cabot-search huggingface dataset:
Internal Medicine and Family Medicine
Authors: Carlos A. Reyes-Ortiz
Journal: Annals of Internal Medicine (1996)

Letters15 September 1996Internal Medicine and Family MedicineCarlos A. Reyes-Ortiz, MDCarlos A. Reyes-Ortiz, MDMcGuire Veterans Affairs Medical Center, Richmond, VA 23249Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-6-199609150-00048 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Saultz [1] raised an important topic in his article on the relationship between internal medicine and family medicine. Although internists always teach family medicine residents, it is unusual for family physicians to teach internal medicine residents.General internal medicine might learn from family medicine experience without duplicate resources. For example, primary care and psychosocial skills are important components of the curriculum of general internal medicine residencies, and these skills are essential components of the family medicine curriculum [2].Primary care skills in the internist are essential for effective ambulatory care (for example, management of common diseases ...References1. Saultz JW. Reflections on internal medicine and family medicine. Ann Intern Med. 1996; 124:600-3. Google Scholar2. Graduate Medical Education Directory 1994-1995. Chicago: American Medical Association; 1994. Google Scholar3. Wartman SA, O'Sullivan PS, Cyr MG. Ambulatory-based residency education: improving the congruence of teaching, learning, and patient care. Ann Intern Med. 1992; 116:1071-5. Google Scholar4. Robbins AS, Cope DW, Campbell L, Vivell S. Expert ratings of primary care goals and objectives. J Gen Intern Med. 1995; 10:429-35. Google Scholar5. Evaluation of humanistic qualities in the internist. American Board of Internal Medicine. Ann Intern Med. 1983; 99:720-4. Google Scholar Author, Article, and Disclosure InformationAuthors: Carlos A. Reyes-Ortiz, MDAffiliations: McGuire Veterans Affairs Medical Center, Richmond, VA 23249 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1996Volume 125, Issue 6Page: 525-526KeywordsEpidemiologyPatientsResidency ePublished: 15 August 2000 Issue Published: 15 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Role of Endoscopic Ultrasonography in Guiding Intralesional Steroid Injections in Esophageal Strictures
Authors: P. V. J. Sriram, R. Kochbar, K. Singh
Journal: Endoscopy (1998)

See also: Endoscopic Ultrasound Miniprobe-Guided Steroid Injection for Treatment of Refractory Esophageal StricturesEndoscopy 1997; 29(08): 757-759DOI: 10.1055/s-2007-1004304 See also: Feasibility and Usefulness of Endoscopic Ultrasound Miniprobe-Guided Steroid Injection in Esophageal StricturesEndoscopy 1998; 30(08): 743-743DOI: 10.1055/s-2007-1001404
Role of MAPK Signaling And NF-kB In Dendritic Cells Maturation In Patients With Non Immediate Allergic Reactions To Amoxicillin
Authors: S. Lopez, C. Antunez, E. Gomez, P. Chaves, L. Melendez, M. Torres, M. Blanca, C. Mayorga
Journal: Journal of Allergy and Clinical Immunology (2010)
Symptoms of Ovarian Cancer—Where to Set the Bar?
Authors: Mary B. Daly
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Haemostasis: Biochemistry, Physiology, and Pathology
Authors: David Green
Journal: JAMA (1978)

Sweeping advances in our knowledge of the hemostatic mechanism have occurred within the past ten years. Much progress has been made in the areas of platelet biochemistry and physiology, structure-function relationships of individual clotting factors, the initiation of coagulation and fibrinolysis, and the role of coagulation inhibitors. This new knowledge of the basic mechanisms of hemostasis has provided greater insight into the pathophysiology of inherited and acquired coagulation disorders and has led to more rational therapeutic interventions. <i>Haemostasis: Biochemistry, Physiology, and Pathology</i>, edited by D. Ogston and B. Bennett, is a repository for much of this new information. The book, composed of 26 chapters authored by 24 contributors, focuses predominantly on the biochemistry of the hemostatic constituents (the first 350 pages), and in the last ten chapters deals with pathophysiological relationships. Highlights include a discussion of the surface-mediated initiation of blood coagulation by O. D. Ratnoff, a 60-page description of
Radiofrequency catheter ablation of common atrial flutter: Comparison of electrophysiologically guided focal ablation technique and linear ablation technique
Authors: Shih-Ann Chen, Chern-En Chiang, Tsu-Juey Wu, Ching-Tai Tai, Shih-Huang Lee, Chen-Chuan Cheng, Chuen-Wang Chiou, Kwo-Chang Ueng, Zu-Chi Wen, Mau-Song Chang
Journal: Journal of the American College of Cardiology (1996)
Abstract B7: ETS1 overexpression in prostate cancer cells
Authors: Jacqueline M. Bentel, Jennet Harvey, Marc A. Thomas, Jamie J. Rodgers, Ebony J. Rouse, Darren M. Preece, Siaw M. Chai, Michael R. Epis, Ronald J. Cohen, Peter J. Leedman, Kimberley Roehrig
Journal: Cancer Research (2012)

Abstract The ETS1 transcription factor is overexpressed in human prostate cancers in comparison to nonmalignant prostate and exhibits nuclear, in addition to aberrant cytoplasmic localisation. A previous report has identified direct interaction between ETS1 and the androgen receptor (AR) in the prostate cancer cell line, LNCaP and we have demonstrated that this ligand-dependent interaction is mediated via the ETS (DNA binding) domain of ETS1 and the ligand-binding domain of the AR. In a cohort of 44 prostate cancer cases, mRNA for the full-length ETS1 isoform, p54ETS1 was detected in all prostate tumour and adjacent nonmalignant prostate tissues, while expression of the internally truncated p42ETS1 isoform was very low or undetectable. In protein lysates extracted from the same cases, p54ETS1 was detected in all samples, with expression of a lower molecular weight ETS1 corresponding in size to the dominant negative p27ETS1 isoform also observed. Increased expression of one or both of the ETS1 isoforms was identified in 38 (86%) cases, supporting the elevated expression of ETS1 in human prostate tumours. Both ETS1 and the AR upregulate expression of the prostatic tumour suppressor, NKX3.1 via sequences located in the 5′ promoter and 3′ untranslated region (3′UTR), respectively. Although unresponsive to androgens, the proximal ∼2kb of the NKX3.1 promoter, and in particular a 76bp sequence surrounding the ETS binding site (EBS) become androgen responsive following ETS1 overexpression. In addition, in LNCaP cells that stably overexpress p54ETS1, the biphasic proliferative responses to androgens, where low (≤10−10M) DHT concentrations stimulate proliferation and higher (&amp;gt;10−10M) DHT levels inhibit proliferation, were altered and DHT concentrations as low as 10−12M inhibited proliferation. The findings indicate that the increased expression of ETS1 commonly observed in human prostate tumours may modify the androgen responsiveness of the cancer cells, augmenting AR-mediated regulation of androgen target genes and potentially sensitising prostate cancer cells to the very low androgen levels in men treated with androgen ablation therapies. Citation Format: Jacqueline M. Bentel, Jennet Harvey, Marc A. Thomas, Jamie J. Rodgers, Ebony J. Rouse, Darren M. Preece, Siaw M. Chai, Michael R. Epis, Ronald J. Cohen, Peter J. Leedman, Kimberley Roehrig. ETS1 overexpression in prostate cancer cells [abstract]. In: Proceedings of the AACR Special Conference on Advances in Prostate Cancer Research; 2012 Feb 6-9; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(4 Suppl):Abstract nr B7.
Reduced Myocardial Flow Reserve in Non–Insulin-Dependent Diabetes Mellitus
Authors: Ikuo Yokoyama, Shin-ichi Momomura, Tohru Ohtake, Katsunori Yonekura, Junichi Nishikawa, Yasuhito Sasaki, Masao Omata
Journal: Journal of the American College of Cardiology (1997)
Cholesterol and Disease—What Are the Facts?
Authors: Robert I. Levy
Journal: JAMA (1982)

Coronary heart disease (CHD), caused usually by the secret and silent process atherosclerosis, is the number one killer disease in the United States today. High serum cholesterol levels, along with cigarette smoking and high BP, have clearly been established as the major risk factors for CHD. The evidence is extensive and unequivocal. There exist overwhelmingly persuasive data based on population studies, animal experimentation, and clinical and pathological investigation that clearly link higher plasma cholesterol levels with higher CHD morbidity and mortality.<sup>1,2</sup> The evidence from a host of different prospective and retrospective studies carried out in many countries reveals that the higher the cholesterol level, the greater the risk of CHD. In individual subjects around the world, it can be shown that the cholesterol level, although clearly in part under genetic control, is greatly affected by environmental factors, especially diet. The higher the level of saturated fat and cholesterol in
Prevalence and natural history of histologically proven chronic liver disease in a longitudinal cohort of patients with type 1 diabetes
Authors: David J. Harman, Philip V. Kaye, Rebecca Harris, Ayako Suzuki, Anastasios Gazis, Guruprasad P. Aithal
Journal: Hepatology (2014)

Although a higher prevalence of raised liver enzymes and altered echotexture on ultrasound have been reported in patients with type 1 diabetes mellitus (T1DM), the histological spectrum and natural history of chronic liver disease (CLD) in T1DM is unknown. We investigated the prevalence and outcome of histologically proven CLD in a longitudinal cohort of patients with T1DM. We identified patients who have had liver biopsy from a computerized database (DIAMOND; Hicom Technology, Brookwood, UK) containing longitudinal data for over 95% of type 1 diabetes patients from an overall catchment population of 700,000 people. Gender-matched patients with oral hypoglycemic-treated (T2OH) and insulin-treated type 2 diabetes (T2IN) who had liver biopsy formed two comparative cohorts. We collated clinical and histological data, as well as long-term outcomes of all three groups, and compared T1DM cirrhosis incidence to UK general population data. Of 4,644 patients with T1DM, 57 (1.2%) underwent liver biopsy. Of these, 53.1% of patients had steatosis, 20.4% had nonalcoholic steatohepatitis, and 73.5% had fibrosis on index liver biopsy. Cirrhosis was diagnosed in 14 patients (24.6%) during follow-up. T1DM with age under 55 years had an odds ratio of 1.875 (95% confidence interval: 0.936-3.757) for cirrhosis incidence, compared to the general population. Longitudinal liver-related outcomes were similar comparing the T1DM cohort and respective type 2 diabetes cohorts—when adjusted for important confounders, diabetic cohort type did not predict altered risk of incident cirrhosis or portal hypertension. Conclusion : Type 1 diabetes is associated with a previously unrecognized burden of CLD and its complications. (Hepatology 2014;60:158–168)
Colonoscopy and Barium Enemas
Authors: RICHARD H. MARSHAK
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 May 1979Colonoscopy and Barium EnemasRICHARD H. MARSHAK, M.D.RICHARD H. MARSHAK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-5-856_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I write to respond to the article by Tedesco and associates in the December 1978 issue (1).The validity of this study should be questioned because (as the author states in the Material and Methods section), the barium enema results were taken from reports on hospital charts in a retrospective study. That some of the films were reviewed but the number of cases that were reviewed or the identity of the reviewers is not given is stated. Roscoe Miller (2) has published an article citing 54 colonoscopic errors.Rather than encouraging cooperation with radiologists, the article stirs...References References1. TEDESCOWAYERASKINMORRISGREENWALD FJJSR: Colonoscopic evaluation of rectal bleeding. A study of 304 patients. Ann Intern Med 89:907-909, 1978 LinkGoogle Scholar2. MILLERLEHMAN RG: Polypoid colonic lesions undetected by endoscopy. Radiology 129:295-297, 1978 CrossrefMedlineGoogle Scholar1. SWARBRICKFEVREHUNTTHOMASWILLIAMS EDRBC: Colonoscopy for unexplained rectal bleeding. Br Med J 2:1685-1687, 1978 CrossrefMedlineGoogle Scholar2. TEAGUETHORNTONMANNINGSALMONREAD RJAPA: Colonoscopy for investigation of unexplained rectal bleeding. Lancet 1:1350-1352, 1978 CrossrefMedlineGoogle Scholar3. TEDESCOWAYERASKINMORRISGREENWALD FJJSR: Colonoscopic evaluation of rectal bleeding. A study of 304 patients. Ann Intern Med 89:907-909, 1978 LinkGoogle Scholar4. HUNT R: Rectal bleeding. Clin Gastroenterol 7:719-740, 1978 CrossrefMedlineGoogle Scholar5. ZAVALA D: Diagnostic fiberoptic bronchoscopy: techniques and results of biopsy in 600 patients. Chest 68:12-16, 1975 CrossrefMedlineGoogle Scholar6. SANDERSON D: Bronchofiberscopy—fiberoptic bronchoscopy (editorial). Chest 68:2, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD H. MARSHAK, M.D.Affiliations: Mt. Sinai School of Medicine Mt. Sinai Hospital New York, NY 10028 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1979Volume 90, Issue 5Page: 856-857KeywordsChartsColonoscopyRadiologistsRetrospective studies ePublished: 1 December 2008 Issue Published: 1 May 1979 PDF downloadLoading ...
Increased systemic production of carbon monoxide in patients with cirrhosis and ascites with and without spontaneous bacterial peritonitis (SBP)
Authors: D. De Las Heras, R. Ortega, P. Gines, A. Cardenas, J. Fernandez, M. Guevara, B. Calahorra, J.A. Barbera, M. Navasa, W. Jimenez, V. Arroyo, J. Rodés
Journal: Journal of Hepatology (2002)
Studying restoration of brain function with fetal tissue grafts: Optimal models
Authors: Rae Silver, Joseph LeSauter
Journal: Behavioral and Brain Sciences (1995)

Abstract We concur that basic research on the use of CNS grafts is needed. Two important model systems for functional studies of grafts are ignored by Stein &amp; Glasier. In the first, reproductive function is restored in hypogonadal mice by transplantation of GnRH-synthesizing neurons. In the second, circadian rhythmicity is restored by transplantation of the suprachiasmatic nucleus.
Assessing confounding, effect modification, and thresholds in the association between ambient particles and daily deaths.
Authors: J Schwartz
Journal: Environmental Health Perspectives (2000)

I examined the relationship between daily deaths and airborne particles in 10 U.S. cities with varying climatic conditions and seasons in which particle concentrations were high. Airborne particles were associated with significant increases in daily deaths [0.67% increase for a 10 microg/m(3) increase in particles; 95% confidence interval (CI), 0.52-0.81%]. This association was the same in summer and winter. To examine potential confounding by other pollutants, I regressed city- and season-specific effect sizes against the relationship between airborne particles and other pollutants. Controlling for other pollutants did not substantially (or significantly) change the estimated effect of airborne particles. Socioeconomic differences between cities likewise did not modify the effect. The increase in daily deaths that occurred out of hospitals (0.89% per 10 microg/m(3); CI, 0.67-1.10%) was substantially greater than the increase in deaths in hospitals (0. 49%; CI, 0.31-0.68%). This is consistent with results previously reported in Philadelphia, Pennsylvania, and suggests that the particle-associated deaths are not just being brought forward by a few days. It is also consistent with recent animal and human studies of the mechanisms of particle toxicity.
Atenolol and metoprolol once daily in hypertension.
Authors: A K Scott, J W Rigby, J Webster, G M Hawksworth, J C Petrie, H G Lovell
Journal: BMJ (1982)

The effect of once-daily dosage of the two most widely prescribed cardioselective beta-adrenoceptor antagonists used to treat hypertension--namely, atenolol and metoprolol--was studied in nine carefully selected hypertensive outpatients. Each patient received atenolol 50 mg/day, atenolol 100 mg/day, metoprolol 100 mg/day, and metoprolol 200 mg/day in a sustained-release formulation (as Lopresor SR) according to a randomised sequence. After three weeks9 treatment with each drug given once daily comparisons of the treatments 24 hours after dosing showed no important differences between 50 and 100 mg atenolol/day. Metoprolol, as both the standard and the slow-release formulations, had some limitations in controlling systolic blood pressure and heart rate. These results suggest that the recommendations for the treatment of hypertension with these cardioselective beta-adrenoceptor antagonists should be reconsidered since doses smaller than those recommended are almost as effective and much cheaper.
The Case for Hyperbaric Oxygen Radiotherapy
Authors: Orliss Wildermuth
Journal: JAMA (1965)

The proposition for the use of hyperbaric oxygen or "hybaroxia" in the radiation therapy of cancer stands firmly on its foundation in radiation chemistry, radiation physics, and radiation biology. The electromagnetic energy generated in an x-ray machine or derived from nuclear disintegration of isotopes produces ions on impact with substances of atomic structure. The ions are the result of energy disruptions of the electron orbits of the atom, of which the biologic target is made. By the subtraction of an electron in one place and the addition in another, ionizations and free radicals are produced. Such events allow for the disturbance of the normal equilibrium of the chemical substrate making up the biologic material. From radiophysics and chemistry, a simplified explanation of the oxygen effect on ion production may be found in water studies—a relevant consideration in that biologic tissues have been referred to as an aquarium of living molecules.
Clinical competence and the Ombudsman
Authors: P. Sowerby, W A Brighouse
Journal: BMJ (1978)

Within three weeks of discontinuing all therapy his haemoglobin concentration began to rise and on 5 December was normal (14-7 g/dl), the patient remaining well.Was this patient's pure red-cell aplasia due to prolonged oestrogen therapy, the first manifestation of an otherwise occult malignant disease, or simply an unrelated episode due, perhaps, to an unrecognised virus infection ?It is impossible to decide at present, because the curious tendency of this type of marrow disorder to remit, sometimes for long periods,7 makes the role of external agents extremely difficult to evaluate.
Treatment strategy for small hepatocellular carcinoma: Comparison of long-term results after percutaneous ethanol injection therapy and surgical resection
Authors: Junji Yamamoto, Shuichi Okada, Kazuaki Shimada, Takushi Okusaka, Susumu Yamasaki, Hideki Ueno, Tomoo Kosuge
Journal: Hepatology (2001)

This comparative study was conducted to clarify the efficacy of percutaneous ethanol injection (PEI) and surgical resection in the treatment of small hepatocellular carcinomas (HCC). Thirty-nine patients treated by PEI and 58 who underwent hepatic resection for small HCC (smaller than 3 cm and 3 or less in number) during the same period were enrolled. The surgery group included more patients with large and multiple bilobar nodules than the PEI group. The histological differentiation of the treated tumors became worse in the surgery patients than in those treated by PEI. On the other hand, the PEI group included more patients with a poor hepatic reserve, according to Child-Pugh grading, the ICG test, and the serum total bilirubin value. The 1-, 3-, and 5-year overall survival rates were almost identical between the 2 cohorts (100%, 82.1%, and 59.0%, respectively, in the PEI group; 96.6%, 84.4%, and 61.5%, respectively, in the surgery group) ( P = .96). During the follow-up period, 33 of 39 (85%) and 41 of 58 (71%) patients developed tumor recurrence after PEI and surgery, respectively. Cumulative 1-, 3-, and 5-year tumor-free survival rates in the PEI group were 63.4%, 30.3%, and 9.7 %, whereas those in the surgery group were 75.5%, 44.7%, and 25.7%, respectively ( P = .10). Our overall findings show that local therapy can achieve an actual 5-year survival rate of around 60% for patients with small HCC with the proper selection of treatment. A prospective randomized comparative trial is required to settle this longstanding issue.
Atrial Fibrillation and Incident Myocardial Infarction
Authors: Eric N. Prystowsky, Edward T. Fry
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OVERVIEW OF PATIENT PREFERENCE AND PERCEPTION OF CARE PROVIDED BY ADVANCED NURSE PRACTITIONERS AND ADULT CONGENITAL PHYSICIANS IN AN OUTPATIENT ADULT CONGENITAL CLINIC
Authors: Stephen C. Cook, Vanessa Kowalski, Jenne Hickey, Renee Schnug, Genise Green, Morgan Hindes, Timothy Maul, Ali Zaidi
Journal: Journal of the American College of Cardiology (2014)