Non-Insulin-Dependent Diabetes Mellitus Developing during Interferon-α Therapy for Chronic Hepatitis C
Authors: Pierre Chedin
Journal: Annals of Internal Medicine (1996)

Letters15 September 1996Non-Insulin-Dependent Diabetes Mellitus Developing during Interferon-α Therapy for Chronic Hepatitis CPierre Chedin, MD, Juliette Cahen-Varsaux, MD, and Nathalie Boyer, MDPierre Chedin, MDVictor Dupony Hospital, 95107 Argenteuil, FranceBeaujon Hospital, 92118 Clichy, FranceSearch for more papers by this author, Juliette Cahen-Varsaux, MDVictor Dupony Hospital, 95107 Argenteuil, FranceBeaujon Hospital, 92118 Clichy, FranceSearch for more papers by this author, and Nathalie Boyer, MDVictor Dupony Hospital, 95107 Argenteuil, FranceBeaujon Hospital, 92118 Clichy, FranceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-6-199609150-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Development of non–insulin-dependent (autoimmune) diabetes mellitus has been suggested in patients treated with interferon-α [1-3]. We describe a patient who developed this disease with no evidence of an immune process while receiving interferon-α for hepatitis C.A 50-year-old man was referred to us because of chronic active hepatitis C. His cousin had insulin-dependent diabetes, but no family member had a history of non–insulin-dependent diabetes. Recombinant interferon-α was started at a dose of 32 million U three times a week. Before therapy, the patient had glucose intolerance. After 1 week of treatment, his fasting plasma blood glucose level ...References1. Fabris P, Betterle C, Floreani A, Greggio NA, De Lazzari F, Naccarato R, et al. Development of type 1 diabetes mellitus during interferon-alfa therapy for chronic HCV hepatitis. Lancet. 1992; 340:548. Google Scholar2. Murakami M, Iriuchijima T, Masatomo M. Diabetes mellitus and interferon-α therapy [Letter]. Ann Intern Med. 1995; 123:318. Google Scholar3. Guerci AP, Guerci B, Levy-Marchal C, Ongagna J, Ziegler O, Candiloros H, et al. Onset of insulin-dependent diabetes mellitus after interferon-alfa therapy for hairy cell leukemia. Lancet. 1994; 343:1167-8. Google Scholar4. Koivisto VA, Peklonen R, Cantel K. Effect of interferon on glucose tolerance and insulin sensitivity. Diabetes. 1989; 38:641-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Pierre Chedin, MD; Juliette Cahen-Varsaux, MD; Nathalie Boyer, MDAffiliations: Victor Dupony Hospital, 95107 Argenteuil, FranceBeaujon Hospital, 92118 Clichy, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCharacteristics of Interferon-Associated Diabetes Mellitus in Past 30 Years: A ReviewGlucose abnormalities in hepatitis C virus infectionThe outcomes of glucose abnormalities in pre-diabetic chronic hepatitis C patients receiving peginterferon plus ribavirin therapyPegylated interferon plus ribavirin therapy improves pancreatic β-cell function in chronic hepatitis C patientsDrug-Induced Endocrine AutoimmunityAssociation of pancreatic autoantibodies and human leukocyte antigen haplotypes with resolution of diabetes mellitus after therapy for hepatitis C virus infection in patients with HIV infection: case report and review of literatureSevere hyponatremia caused by hyperglycaemia due to interferon alpha therapy in advanced renal cell carcinomaDrug-Induced Hyperglycemia and Diabetes MellitusHepatitis C infection and diabetesType 1 diabetes mellitus in patients with chronic hepatitis C before and after interferon therapyAbrupt onset of diabetes during interferon-alpha therapy in patients with chronic hepatitis CIslet cell and thyroid antibody prevalence in patients with hepatitis C virus infection: Effect of treatment with interferonIncreased Risk of Type 2 Diabetes in Noncirrhotic Patients With Chronic Hepatitis C Virus InfectionGastrointestinale Komplikationen des Diabetes mellitusAutoimmunity induced by interferon-α therapy for chronic viral hepatitisExpression and cytokine regulation of immune recognition elements by normal human biliary epithelial and established liver cell lines in vitroThe Endocrine Effects of Nonhormonal Antineoplastic TherapyDrugs acting on the immune systemInterferon-?? 15 September 1996Volume 125, Issue 6Page: 521KeywordsAntibodiesAutoantibodiesBlood plasmaGlucoseGlucose intoleranceHepatitis CImmunoprecipitationInsulinThyroid-stimulating hormoneType 2 diabetes ePublished: 15 August 2000 Issue Published: 15 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...