tbuckley/cabot-search huggingface dataset:
SODIUM COLISTIMETHATE DOSAGE IN RENAL FAILURE
Authors: Donald N. Mackay, Donald Kaye
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 September 1968SODIUM COLISTIMETHATE DOSAGE IN RENAL FAILUREDONALD N. MACKAY, M.D., DONALD KAYE, M.D.DONALD N. MACKAY, M.D.Search for more papers by this author, DONALD KAYE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-3-639_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The recent article by Goodwin and Friedman, "The Effects of Renal Impairment, Peritoneal Dialysis, and Hemodialysis on Serum Sodium Colistimethate Levels" (Ann. Intern. Med. 68: 984, 1968) contains several statements with which we disagree. These are as follows:[1] Goodwin and Friedman state that peak serum concentrations in our study (1) were higher than those obtained in 10 patients studied by Wright and Welch. However, Wright and Welch's data reveal that only 5 of their 10 subjects had peak level studies and that these were in the same range as ours, being 5.8 to 13.0 µg/ml (mean,...Reference References1. MACKAYKAYE DND: Serum concentrations of colistin in patients with normal and impaired renal function. New Eng. J. Med. 270: 394, 1964. CrossrefMedlineGoogle Scholar1. WRIGHTWELCH WWH: Chemical, biological, and clinical observations on colistin. Antibiot. Ann. 7: 61, 1959-1960. MedlineGoogle Scholar2. MACKAYKAYE DND: Serum concentrations of colistin in patients with normal and impaired renal function. New Eng. J. Med. 270: 394, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONALD N. MACKAY, M.D.; DONALD KAYE, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1968Volume 69, Issue 3Page: 639-641KeywordsAttentionPeritoneal dialysisRenal failureSodium ePublished: 1 December 2008 Issue Published: 1 September 1968 PDF downloadLoading ...
A Comprehensive Assessment of the Value of Laboratory Indices in Diagnosing Kawasaki Disease
Authors: Qing Ye, Wen‐xia Shao, Shi‐qiang Shang, Ting Zhang, Jian Hu, Chun‐chun Zhang
Journal: Arthritis & Rheumatology (2015)

Kawasaki disease (KD) is the primary cause of heart disease among children, but because its clinical symptoms are nonspecific, it is difficult to diagnose. The purpose of this study was to evaluate laboratory indices for possible use in the early diagnosis of KD and to determine which indices are predictive of a response to intravenous immunoglobulin (IVIG) and can be used to monitor the effects of treatment.Three hundred thirty KD patients, 330 age-matched children with KD-like febrile disease, and 330 age-matched healthy children (controls) were enrolled in this prospective study. Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and cytokines were determined in all study subjects.In the derivation cohort, 181 patients in the KD group were compared with 181 patients in the KD-like febrile group. The following indices were found to be useful in the diagnosis of KD: NT-proBNP (area under the curve [AUC] 0.923), ESR (AUC 0.909), CRP (AUC 0.834), and interleukin-6 (IL-6; AUC 0.678). The diagnostic efficiency of each index demonstrated in the derivation cohort was repeated in the 149 KD patients in the validation cohort. There were significant differences in NT-proBNP levels between IVIG-responsive KD patients (n = 270) and IVIG-nonresponsive KD patients (n = 60), with higher NT-proBNP levels in IVIG-nonresponsive KD patients. The NT-proBNP level can effectively distinguish IVIG-responsive KD patients from IVIG-nonresponsive patients, and its AUC was 0.73. There were also significant differences in the NT-proBNP levels before and after treatment, with a significant decline after treatment.Serum levels of NT-proBNP can be used in the diagnosis of KD, the prediction of a patient's sensitivity to IVIG treatment, and the monitoring of the effects of IVIG treatment, but more attention must be paid to the scope of its application.
Phase I Evaluation of J591 as a Vascular Targeting Agent in Progressive Solid Tumors
Authors: Michael J. Morris, Neeta Pandit-Taskar, Chaitanya R. Divgi, Samantha Bender, Joseph A. O'Donoghue, Angelo Nacca, Peter Smith-Jones, Lawrence Schwartz, Susan Slovin, Ronald Finn, Steven Larson, Howard I. Scher
Journal: Clinical Cancer Research (2007)

Abstract Purpose: The antibody J591 targets the external domain of prostate-specific membrane antigen, which is expressed in the neovasculature of nonprostate solid tumors. This phase I trial tested the hypothesis that J591 could be used as a vascular targeting platform for patients with nonprostate solid tumors. Experimental Design: Patients with progressive solid tumors were eligible. Twenty patients, divided into six dosage cohorts of 3 to 6 patients each, were treated every 3 weeks to a maximum of four doses using either 5, 10, 20, 40, 60, or 100 mg of J591 antibody. Two milligrams of antibody were labeled with 10 mCi of indium-111. Results: Patients with a wide variety of solid tumors were tested; all had good tumor localization. No dose-limiting toxicities were observed. The serum clearance rate decreased with increasing antibody mass, likely a result of early hepatic uptake of antibody. Half-life for each successive cohort was 0.71, 0.84, 1.86, 1.83, 3.32, and 3.56 days. Hepatic saturation seemed to occur by 60 mg. Seventeen of 18 (94%) patients with soft tissue disease on standard scans showed uptake in the soft tissues on antibody scans as did 6 of 6 patients with bone disease. Conclusions: The tumoral neovasculature of a variety of solid tumors can be selectively and safely targeted using J591. In planning for future studies using J591 as a radiation delivery platform, an antibody mass of 60 mg should be considered, as it would seem to minimize the radiation delivered to the liver while minimizing the radiation dose to bone.
Immunity Against Contagious Diseases: Inadequacies
Authors: Hugh H. Hussey
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practice Parameter for the Use of Fresh-Frozen Plasma, Cryoprecipitate, and Platelets
Authors: E. Shannon Cooper
Journal: JAMA (1994)

THESE guidelines have been prepared to assist the ordering physician in selecting the proper blood component for obtaining and maintaining hemostasis. While it is not possible to detail every clinical situation for which these components may be indicated, these guidelines will cover most important states. Since these guidelines were developed for adult patients, they may not apply in all cases for pediatric transfusions. Also, these guidelines do not eliminate the need for expert consultation in this complex area of medical practice, and in situations that involve very complex massive bleeding physicians may not be able to adhere to them. It should be understood that adherence to parameters does not guarantee a successful outcome. Rather, these parameters are provided as an educational tool to assist physicians in providing quality care. If equally valid parameters or views advanced by other respected groups are applicable, the physician is, of course, free to follow
THERAPEUTICS XII.
Authors: Heather Ashton, G. W. Beveridge, C. J. Stevenson
Journal: British Journal of Dermatology (1970)

Journal Article THERAPEUTICS XII: Lincomycin and Clindamycin Get access Heather Ashton, Heather Ashton Pharmacology Department University of Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar G. W. Beveridge, G. W. Beveridge Royal Infirmary Edinburgh Search for other works by this author on: Oxford Academic Google Scholar C. J. Stevenson C. J. Stevenson Royal Victoria Hospital Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 83, Issue 5, 1 November 1970, Pages 604–606, https://doi.org/10.1111/j.1365-2133.1970.tb15752.x Published: 01 November 1970
Prevalence of Elevated Serum Transferrin Saturation in Adults in the United States
Authors: Anne C. Looker
Journal: Annals of Internal Medicine (1998)

Background: A population-based hemochromatosis screening program that uses serum transferrin saturation has been proposed, but few data exist on the number of U.S. adults that such a program would identify for further testing. Objective: To determine the prevalence of an initially elevated serum transferrin saturation and the prevalence of concurrently elevated serum transferrin saturation and serum ferritin levels in the adult population of the United States. Design: Nationally representative cross-sectional survey of the noninstitutionalized U.S. civilian population. Participants: 15 839 men and nonpregnant women 20 years of age and older who were examined in the third National Health and Nutrition Examination Survey (1988-1994). Measurements: Single measurements of serum transferrin saturations and serum ferritin levels. Cut-off values used to define elevated serum transferrin saturation ranged from greater than 45% to greater than 62%. Results: The prevalence of initially elevated serum transferrin saturation ranged from 1% to 6%. Approximately 11% to 22% of those with elevated serum transferrin saturation had concurrently elevated serum ferritin levels. The prevalence of elevated serum transferrin saturation was lower in women than in men when the same cut-off value was used to define elevated serum transferrin saturation. The prevalence of elevated serum transferrin saturation in non-Hispanic black persons and Mexican-Americans was similar to or slightly less than that in non-Hispanic white persons. The prevalence of elevated serum transferrin saturation in persons 20 to 49 years of age was as high as or higher than that in older adults. Conclusions: A hemochromatosis screening program that uses a cut-off value of greater than 60% to define elevated serum transferrin saturation would identify an estimated 1.4 to 2.5 million U.S. adults for further testing.
Influence of differential vascular remodeling on the coronary vasomotor response
Authors: A MCLEOD, D NEWBY, D NORTHRIDGE, K FOX, N UREN
Journal: Cardiovascular Research (2003)

Objectives: Arterial remodeling may increase or decrease the luminal encroachment of atherosclerotic plaques in the coronary circulation. However, the factors determining the nature and consequences of the remodeling process remain poorly characterized. The study aims were to assess whether the pattern of vascular remodeling influences the physical and vasomotor responses of the coronary arteries in vivo in man. Methods: Coronary vessel area, distensibility and stiffness were determined in positively, negatively and non-remodeled arterial segments using intravascular ultrasound and Doppler flow measurement. Epicardial vasomotor responses were determined following intracoronary boluses of acetylcholine (10−6 and 10−4 M), adenosine (24–30 μg) and nitroglycerin (200 μg). Results: Fifty-six coronary arterial segments were studied in 25 patients. In comparison to non- and positively remodeled segments, negatively remodeled segments had a higher stiffness index (67±16 vs. 33±5 and 38±8, respectively; P<0.02) and appeared to have lower compliance and distensibility (0.66±0.17 vs. 1.65±0.54 and 0.94±0.18/mmHg; P = NS). Non-remodeled segments had a greater change in vessel area with 10−6 M acetylcholine (4.9±0.8%), compared to positively and negatively remodeled segments (0.6±1.8% and −4.9±1.8%, respectively, P<0.05). A significant degree of preservation of vasodilatation to 10−6 M acetylcholine was evident in positively remodeled compared with negatively remodeled segments (P<0.05). Nitroglycerin caused greater vasodilatation in non-remodeled segments (7.2±3.8%) than either positively or negatively remodeled segments (4.7±0.9 and 3.7±0.6%, respectively, P<0.05). Conclusions: Vascular remodeling is an important and major determinant of local epicardial vasomotor responses. Both structural and functional abnormalities are associated with negative remodeling that may contribute to the adverse effects of such lesions.
New Kidney Allocation System
Authors: Tracy Hampton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac genomic response following preconditioning stimulus
Authors: D DAS, N MAULIK
Journal: Cardiovascular Research (2006)

This review focuses on the genomic response following a preconditioning stimulus. Initial studies demonstrated that classical ischemic preconditioning mediated by cyclic episodes of short durations of reversible ischemia and reperfusion could result in the reprogramming of gene expression. Some of these genes are translated into proteins during the late preconditioning or so-called "second window of protection". Subsequent studies determined a unique similarity of the expressed gene profiles between diverse varieties of preconditioning including ischemic/hypoxic, heat shock, and oxidative stress. The most common genes that are expressed by virtually any kind of stress conditioning include antioxidants like superoxide dismutase, glutathione peroxidase and heme oxygenase and heat shock proteins such as HSP70. At a later date, differential display and subtractive hybridization techniques revealed the identities of many other genes including those belonging to mitochondrial respiratory chain such as ATPases. More recently, gene array profiles using gene chips determined several other genes triggered by preconditioning including the mitochondrial genes. The results of the studies present in the literature clearly indicate the existence of a strong resemblance between the patterns of gene expression profiles induced by diverse preconditioning stimuli, oxidative stress being situated at the cross-roads of all forms of the stresses. Redox signaling appears to be responsible for the conversion of the ischemia/reperfusion-induced "death signal" into preconditioning-mediated "survival signal".
Relation between the Race and Economic Status of Patients and Who Performs Their Surgery
Authors: Lawrence D. Egbert, Ilene L. Rothman
Journal: New England Journal of Medicine (1977)

We evaluated the relation between race and economic status of surgical patients and their likelihood of being treated by a surgeon in training rather than by a staff surgeon. Blacks were 2.2 to 4.3 times more likely than whites to be under the care of surgeons in training (P less than 0.001). This relation has remained unchanged over the past two decades. It remained when the method of payment was via self-payment or private insurance, but disappeared when patients being paid for by Medicaid were considered. In addition, black emergency patients were more likely than white emergency patients to be cared for by surgeons in training.
Newer Drugs in the Treatment of Hypertension
Authors: CHARLES L. RAST, EDWARD S. ORGAIN, JOHN C. MULLER, WILLIAM W. PRYOR, HOMER A. SIEBER
Journal: Circulation (1955)

Sixty-one patients exhibiting severe hypertensive vascular disease were treated with hexamethonium in combination with hydralazine for periods up to 22 months. Results, in terms of blood pressure control, were considerably better with combined therapy than with hexamethonium alone regardless of whether hydralazine was added to hexamethonium initially or later. Improvement in retinopathy and in the electrocardiogram was noted. The malignant phase of hypertensive disease was reversed in eight of nine instances. Late systemic reactions to hydralazine occurred in seven patients. One death, attributed to possible hexamethonium poisoning, was observed. Hexamethonium-hydralazine therapy represents a potent combination of drugs for the treatment of severe hypertensive vascular disease.
A CASE OF DARIER'S DISEASE.PSOROSPERMOSE CUTANEE FOLLICULAIRE VEGETANTE OR KERATOSIS FOLLICULARIS (WHITE).
Authors: DAVID LIEBERTHAL
Journal: JAMA (1904)

In the last fifteen years, since this affection became known under the above names, there was published in all thirty cases.<sup>1</sup>Cases under this heading demonstrated or published by Mansuroff, Zeleneff, Kroesing, Savill, Graham, Little, Sokoloff, Bogroff and Huber lack many essential features, and can not therefore be considered as cases of this affection. <h3>HISTORY OF THE AUTHOR'S CASE.</h3> Our case, which represents the thirty-first of all cases, and the sixth of the cases occurring in the United States, concerns a young man of 25, born in a small town in the south of Wisconsin. His parents are German, and claim that they do not know of any skin disease occurring in their family except the present case. They themselves have always enjoyed excellent health, as did their two daughters of 17 and 18 respectively, and their younger son of 14. The patient passed through an attack of measles in
The effect of insecticide aerosols on lung function, airway responsiveness and symptoms in asthmatic subjects
Authors: C.M. Salome, G.B. Marks, P Savides, W Xuan, A.j Woolcock
Journal: European Respiratory Journal (2000)

The object of this study was to compare the effect of standard and "low irritant" insecticide aerosols on lung function, airway hyperresponsiveness (AHR) and symptoms in asthmatic subjects. A double blind randomized, crossover study was conducted in 25 asthmatic subjects who reported sensitivity to insecticide aerosols. All subjects were exposed for 30 min, on separate occasions, to two standard insecticide formulations (A and B), one low irritant formulation (C) and a negative control aerosol. Spirometric function and chest, nose and eye symptoms were recorded during, and for 90 min after, the exposure. AHR to methacholine was measured 90 min after the exposure. Compared to the negative control, the maximum fall in forced expiratory volume in one second (FEV1) was slightly greater after standard insecticides (mean differences from control +/-95% confidence interval: aerosol A, 3.3+/-3.6%, p=0.08; aerosol B, 5.1+/-4.7%, p=0.04), AHR was significantly more severe (mean difference from control: aerosol A, 0.35+/-0.29 doubling doses, p=0.028; aerosol B, 0.52+/-0.43 doubling doses, p=0.028), and symptoms were more severe. The low irritant test aerosol (C) did not differ significantly from the negative control with respect to FEV1, AHR or symptoms. It is concluded that some insecticide aerosols trigger symptoms and falls in lung function in some people with asthma. Furthermore, these aerosols may also increase airway hyperresponsiveness, although the mechanism of this effect has not been determined. The low irritant formulation did not appear to have the same effects.
Quality of haemofiltration fluids: a potential cause of severe electrolyte imbalance.
Authors: N D Barber, J S Gibbs, P Barrett, K M Fox
Journal: BMJ (1987)

marker that can be used further to investigate differences in the two main aetiological types of diabetes.The parallel of our results for type I diabetes with those for ankylosing spondylitis is striking.In both there are strong associations with particular HLA markers and a significant increase in the proportion of non-secretors.This is further indirect evidence to support the suggestion that an infectious agent is implicated in the initiation of type I diabetes in some genetically predisposed paiients.Determining the secretor state of patients who have various viral infections would be a useful first step in investigating this hypothesis.We suggest that the initial susceptibility to some viral infections might be greater in the non-immune, non-secretor host.The specific immune response to the putative infectious agent, controlled by the class II HLA DR3/4 genes, might contribute to pathogenic sequelae leading to the diabetic state.We are grateful to Dr A E Mourant for helpful discussions and to the Edinburgh and South East Scodand Blood Transfusion Service for reagents used in the study.
Erratum to: Transdermal Nitroglycerin (Glyceryl Trinitrate)
Authors: Peter A. Todd, Karen L. Goa, Heather D. Langtry
Journal: Drugs (1991)

In section 3, line 21, the phrase ' ... preferential affinity for striatal dopaminergic systems . ..' should read ' . . .preferential affinity for extrastriatal dopaminergic systems .
Survival of Treated Hypertensive Patients
Authors: Mitchell Perry
Journal: JAMA (1969)

Dr. Fred Orkin, Intern in Medicine, Jewish Hospital of St. Louis, and Assistant in Medicine, Washington University School of Medicine: A 57-year-old Negro man with known hypertension was hospitalized with a one-week history of severe headache, dizziness, and some difficulty in walking. Three years ago the patient consulted a physician because of headaches. He then had a blood pressure of 184/114 mm Hg, minimal arteriolar narrowing, and arteriovenous nicking. An electrocardiogram was consistent with a diagnosis of anterior subepicardial injury and anterolateral ischemia. The roentgenogram of the chest showed a normalsized heart. The creatinine clearance was 40 and 70 ml per minute, respectively on two occasions. Complete blood cell count, urinalysis, urine culture, catecholamine excretion, and a rapid-sequence intravenous pyelogram revealed no abnormalities. Levels of serum glucose, serum urea nitrogen, uric acid, protein-bound iodine, serum electrolytes, and urinary vanilmandelic acid were within normal limits. On a regimen of methyldopa, 1