tbuckley/cabot-search huggingface dataset:
F-18 FDG PET in the Diagnosis and Monitoring of Salmonella Vertebral Osteomyelitis: A Comparison With MRI
Authors: Zarni Win, Elizabeth O??Flynn, Edward J. O??Rourke, Avril Singh, Graham S. Cooke, Jon S. Friedland, Adil Al-Nahhas
Journal: Clinical Nuclear Medicine (2006)

Vertebral osteomyelitis may be difficult to diagnose by conventional imaging methods. F-18 FDG PET is capable of detecting a lesion in the very early stages, long before there are any visible structural changes. We present a case of salmonella vertebral osteomyelitis in which F-18 FDG PET scanning provides the diagnosis by detecting increased metabolic activity before definitive changes are seen on plain radiography and magnetic resonance imaging (MRI). The imaging findings and SUV on serial follow up F-18 FDG PET studies improved and normalized in correlation with the clinical and biochemical indices, whereas the MRI abnormalities persisted. This assisted in the decision to stop long-term antimicrobial therapy.
Lung immunoglobulins in the sudden infant death syndrome.
Authors: K. D. Forsyth, S. C. Weeks, L. Koh, J. Skinner, J. Bradley
Journal: BMJ (1989)

The incidence of the sudden infant death syndrome parallels that of respiratory tract infections in the paediatric community. On the basis that the aetiology of the sudden infant death syndrome may lie in an unusual response to a trivial intercurrent respiratory infection a necropsy study was carried out investigating pulmonary immunoglobulins in 16 victims of the syndrome and a series of infants (controls) who had died of non-pulmonary causes. Compared with the controls victims of the sudden infant death syndrome had grossly raised concentrations of IgG, IgM, and to a less extent IgA in lung lavage samples. In addition, pulmonary interstitial and terminal airway cells expressing these immunoglobulins were identified far more often in victims than controls. The study failed to determine whether the increased immunoglobulin concentrations were a consequence of an unusual response to a trivial infection or an expression of otherwise altered immunological control in the respiratory tract. Epidemiological evidence and the findings of this study suggest that the respiratory tract is the prime target organ in the sudden infant death syndrome.
PREPARATION AND BIOLOGICAL PROPERTIES OF A CHEMICALLY MODIFIED ESCHERICHIA COLI ENDOTOXIN OF HIGH IMMUNOGENIC POTENCY AND LOW TOXICITY
Authors: Hans Noll, Abraham I. Braude
Journal: Journal of Clinical Investigation (1961)

The choice of LiAlH4 was suggested by earlier studies on the chemical structure of mycobacterial glycolipids.It has been shown that the fatty acids of these lipids are frequently linked to the carbohydrate portion through ester bonds which are reductively cleaved by LiAlH4 without dam- age to the carbohydrate moiety (11-16). MATERIALS AND METHODSReagents.LiAlH, and NaBH4 were purchased from Metalhydrides, Inc. Pyrogen-free saline and distilled water were obtained from the Abbott Company.Decontamination.Equipment (glassware, needles, and so on) was made free of pyrogen by heating at 170°C for 2 hours.Plastic material and other equipment that could not be exposed to this temperature were made pyrogen- free by immersion in 10 per cent NaOH for at least 2 hours and rinsed wvith pyrogen-free distilled water.Bacterial cultures.E. coli of serotype 0: 113, isolated from the blood of a patient, was subcultured on agar containing 5 per cent rabbit blood.Media.For large scale growth, a synthetic salt me- dium, containing glucose as carbon and NH,' as nitrogen source, was used (17).Preparation of endotoxin.The bacteria were grown in 12.5-L batches as described previously (17).Growth was stopped after 18 hours by the addition of 75 ml of a 40 per cent formalin solution.The cultures were har- vested with a DeLaval gyro-test unit, washed with 95 per cent ethanol, followed by acetone, and dried in a vacuum oven at 560 C. The bacterial mass, suspended in 5 parts of distilled water with a Waring Blendor, was incubated at 600 C for 90 minutes and subsequently at 40 overnight.
Sustained statin use is associated with lower risk of death in lung cancer patients, study shows
Authors: S. Mayor
Journal: BMJ (2015)

Patients with lung cancer who have had more than 12 prescriptions for statins after their cancer diagnosis have a significantly lower risk of death from the disease than lung cancer patients who don’t take these commonly prescribed drugs, concludes a study that researchers say supports further investigation into the use of statins as adjuvant cancer therapy.

The study, published in Cancer Epidemiology, Biomarkers & Prevention , identified 14 689 patients in the English cancer registry who had been given a …
Effect of Induced Fever on Sulfobromophthalein Kinetics in Man
Authors: TERRENCE F. BLASCHKE
Journal: Annals of Internal Medicine (1973)

The effect of fever induced by endotoxin or etiocholanolone on sulfobromophthalein (BSP) kinetics was examined in 20 healthy volunteers by analyzing the plasma disappearance curves obtained after a single injection of 5.0 mg/kg body weight of BSP during the fever. In addition to 45-minute retention, BSP clearances, the values for the parameters of a compartmental model of BSP metabolism, and relative hepatic BSP storage capacity were calculated by computer from the experimental curves. Although only 9 of the 20 fever volunteers had abnormal BSP retention at 45 minutes, all pyrogen-treated subjects had significant changes in values for the compartmental parameters. The largest changes were in the values for BSP reflux from liver to plasma, which increased to 587% of control values, and for relative hepatic BSP storage capacity, which fell by 46%. These results indicate that caution must be used in interpreting the BSP test in patients who are even mildly febrile.
Removal of abnormal clone of leukaemic cells by splenectomy.
Authors: G Gomez, D K Hossfeld, J E Sokal
Journal: BMJ (1975)

A patient with chronic myelocytic leukaemia positive for the Philadelphia (Ph-1) chromosome underwent splenectomy in the "terminal phase" of his disease. Chromosomal analysis of a marrow aspirate obtained during the operation showed nothing abnormal. Material from the spleen, however, showed the absence of a C chromosome and the presence of a "marker" chromosome in all metaphases examined. The patient did well for almost three years after splenectomy, and serial cytogenetic studies of marrow specimens showed the Ph-1 chromosome to be the only significant abnormality. Six months before death from recurrent blastic transformation aneuploidy was found in a marrow specimen. Subsequently additional abnormalities, including cells with two Ph-1 chromosomes, were detected. The karyotypic abnormalities found in the splenic specimen, however, never recurred.
SKIN CLEARANCE OF IRON IN NORMAL AND IRON DEFICIENT SUBJECTS
Authors: I. CAVILL, A. JACOBS
Journal: British Journal of Dermatology (1970)

SUMMARY.— 59Fe-ferric citrate was injected into the skin of 23, normal subjects and 6 iron deficient patients. Iron clearance, measured by external scintillation counting, could be resolved into 3 exponential components. The first, rapid component resulted from the removal of unbound iron by the blood stream. A lymphatic component, t1/2 23·9 hr., accounted for; the clearance of two-thirds of the transferrin bound iron from the skin of normal subjects; the remaining one-third was taken up by the epidermal cells arid cleared only slowly (t1/2 67 days) from the injection site; This pattern was not altered by binding the iron to plasma before injection but in the anaemic iron, deficient patients over half of the transferrin bound iron was taken up by the cells. The possible causes of the increase in the epidermal component in iron deficiency are discussed.
Increased inflammatory cytokines and new collagen formation in cutaneous tuberculosis and sarcoidosis.
Authors: B. G. Marshall, A. Wangoo, H. T. Cook, R. J. Shaw
Journal: Thorax (1996)

Interactions between mononuclear cells, vascular endothelium, fibroblasts, and cytokines during the inflammatory reaction within a granuloma have the potential to contribute to the progression to fibrosis.Biopsy specimens of six tuberculous and eight sarcoidosis skin lesions were examined by immunohistochemistry to seek evidence for the presence of inflammatory and fibrotic reactions in human granulomatous disease. Additionally, to understand how a T cell mediated delayed type hypersensitivity reaction--a component of chronic granulomatous inflammation--could progress to fibrosis, the human in vivo model of the cutaneous tuberculin Heaf reaction to purified protein derivative (PPD) was studied in a group of 48 subjects.Granulomas from tuberculous and sarcoidosis skin biopsy specimens were seen to contain cells with marked staining by antibodies to fibronectin, transforming growth factor beta (pan TGF-beta), and type 1 procollagen (PCP-1). Accentuated staining of extracellular matrix was seen both in the granulomas and in the peri-granulomatous regions. Less prominent staining was observed using antibodies against interleukin 1 beta (IL-1 beta) and alpha-smooth muscle actin (alpha-SMA). Biopsies of Heaf reactions revealed cells staining for IL-1 beta, tumour necrosis factor alpha (TNF-alpha), platelet derived growth factor B (PDGF-B), and fibronectin which were detected as early as day 1 and persisted throughout the 14 day study period. Cells staining for PCP-1 increased to greatest abundance at day 14. All these cytokines were present in low abundance in biopsy specimens from sites inoculated with saline only.Evidence is provided that granulomas in tuberculosis and sarcoidosis behave as active centres of fibrogenesis. Using the Heaf model, the temporal relationship between the early appearance of cytokines and the later increase in the collagen precursor PCP-1 linked the immune mediated chronic inflammatory response with subsequent fibrosis and suggested that the tuberculin Heaf reaction will serve as a model for studying the early events of granuloma formation in patients with tuberculosis and sarcoidosis.
Let’s Prioritize the Right Care for the Right Patients With Hypertension
Authors: Paul Arthur James
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Air Pollution as an Emerging Global Risk Factor for Stroke
Authors: Farrah J. Mateen
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thomas Wakley, plagiarism, libel and the founding of <i>The Lancet</i>
Authors: Roger Jones
Journal: Journal of the Royal Society of Medicine (2009)

When the first edition of The Lancet was published in London on Sunday 5 October 1823, it was unusual in that it did not represent the interests of a particular professional group, or report the transactions of a learned society. It was, instead, the product of the fiery indignation and reforming zeal of its founding editor Thomas Wakley. The Lancet was issued at a time when the Government had imposed a tax on newspapers to prevent public unrest and within a decade it had begun to lay the foundations of evidence-based medicine, medical audit and the regulation of the medical profession. The influence of the journal came, however, at a price and with a touch of notoriety, and was in part the result of a series of high-profile clashes between Wakley, senior medical figures and the British legal system.
Epidemiology of adverse events and Clostridium difficile-associated diarrhea during long-term antibiotic therapy for osteoarticular infections
Authors: Maximilian Schindler, Louis Bernard, Wilson Belaieff, Axel Gamulin, Guillaume Racloz, Stéphane Emonet, Daniel Lew, Pierre Hoffmeyer, Ilker Uçkay
Journal: Journal of Infection (2013)
Doctors and Dying
Authors: Ramona M. Chapman
Journal: JAMA (1982)

How to prepare a child for a good-bye visit to a dying loved one? Dr Rubenstein's description of the way she and her husband prepared their children (p 2571) is a useful blueprint. Physicians would do well to give copies of her article to people who have children and dying relatives and friends.  In our society open discussion of death is taboo. Physicians, having grown up in our society, find themselves in a cultural bind. They are supposed to heal, not allow death. They are supposed to comfort, but often cannot face the reality of death.  By breaking the taboo against children's involvement in the death of important relatives, the Rubensteins taught their children that sickness is a part of life and that human beings have a need to say good-bye when time shared is over. The wistful pleasure with which the children mention the last visit to Grandpa emphasizes
Contaminated humidifiers and the lung.
Authors: D J Hendrick
Journal: Thorax (1985)

Contaminated humidifiers and the lungIn 1970 Banaszak and colleagues described four office workers from a total of 27 who complained either of intermittent chills, fever, malaise, aches and pains, cough, and breathlessness or of a more persistent cough and breathlessness alone.'The more acute symptoms generally began towards the end of each work day and regressed within 12 hours.All the symptoms were less obvious at weekends and all subsided completely during holidays.The presence of auscultatory crackles, diffuse interstitial abnormalities on the chest radiograph, a restrictive ventilatory defect (with increase in residual volume), and impairment of gas transfer in some, but not all, of these subjects provided powerful support- ing evidence for a diagnosis of occupational extrinsic allergic alveolitis.Transbronchial biopsy in one sub- ject confirmed the presence of alveolitis, but the working environment contained no obvious organic dust.The answer was found to lie with the office humidifier and air conditioner.Scrapings from the heating coil over which the newly moistened air was passed produced Micropolyspora faeni on culture at 56°C, while sera from each of the affected subjects contained precipitins to the same organism.An inhalation provocation test was carried out in one of the affected people with an extract of the cultured organism, and the clinical features of the disorder were reproduced.The air conditioning process was then modified radically and all these symptoms ceased.These authors had no doubt that they were observing a new cause of extrinsic allergic alveolitis (humidifier lung), but there was a novel feature to which they drew attention-the absence of an aetiological agent in particulate (dust) form.A further point of some interest is that all four affected workers were non-smokers.Subsequent investigations from many different countries have confirmed the validity of these observations, and it is now clear that both occupational and domestic environments are readily vulnerable to contamination with a vari- ety of water borne microorganisms that pose a threat of hypersensitivity (or toxic) responses in sub- stantial proportions of exposed populations without any risk of infection.
TCT-863 Severe Decline In Platelet Count In Patients Treated By Transcatheter Aortic Valve Replacement Is An Independent Correlate For Worse Clinical Outcome
Authors: Danny Dvir, Israel Barbash, Itsik Ben Dor, Rebecca Torguson, Salem Badr, Gabriel Sardi, Lowell Satler, Ron Waksman, Augusto Pichard
Journal: Journal of the American College of Cardiology (2012)
Binding of the JmjC Demethylase JARID1B to LSD1/NuRD Suppresses Angiogenesis and Metastasis in Breast Cancer Cells by Repressing Chemokine CCL14
Authors: Qian Li, Lei Shi, Bin Gui, Wenhua Yu, Jiamu Wang, Di Zhang, Xiao Han, Zhi Yao, Yongfeng Shang
Journal: Cancer Research (2011)

Abstract JARID1B is a member of the JmjC/ARID family of demethylases that specifically demethylates tri- and di-methylated forms of histone H3 lysine 4 (H3K4) that are associated with active genes. JARID1B expression is dysregulated in several cancers in which it has been implicated, but how it might affect tumor progression is unclear. In this study, we report that JARID1B is a physical component of the LSD1/NuRD complex that functions in transcriptional repression. JARID1B and LSD1 acted in a sequential and coordinated manner to demethylate H3K4. A genome-wide transcriptional analysis revealed that among the cellular signaling pathways targeted by the JARID1B/LSD1/NuRD complex is the CCL14 chemokine pathway of cell migration and angiogenesis. JARID1B repressed the expression of CCL14, an epithelial derived chemokine, suppressing the angiogenic and metastatic potential of breast cancer cells in vivo. Our findings indicate that CCL14 is a critical mediator of the JARID1B/LSD1/NuRD complex in regulation of angiogenesis and metastasis in breast cancer, identifying a novel potential therapeutic target for breast cancer intervention. Cancer Res; 71(21); 6899–908. ©2011 AACR.
Costs of HIV/AIDS rise, care disparities increase
Authors: M. F. Goldsmith
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Criminal sanctions for failure to report harms would not deter disclosure, campaigners say
Authors: M. Limb
Journal: BMJ (2013)

Every NHS chief executive and medical and nursing director in England should candidly own up to things that go wrong where they work, Robert Francis QC, who led the public inquiry into events at Mid Staffordshire NHS Foundation Trust, has said.

He said that they should start doing this at once to signal the start of a new culture of openness in the NHS and need not wait for the government to implement his inquiry’s recommendations.

“Organisations can insist on candour now,” he said. This was vital to ensure continuing trust of the public and patients in the NHS and meant that safety related problems could be identified and remedied as soon as possible.

Francis spoke at a conference on openness, transparency, and candour in the wake …
Early rheumatoid disease. II. Patterns of joint involvement.
Authors: A Fleming, R T Benn, M Corbett, P H Wood
Journal: Annals of the Rheumatic Diseases (1976)

Data from the first research clinic visit (Fleming and others, 1976) have been subjected to factor analysis to identify early patterns of joint involvement. Nine patterns emerged. Two patterns, if present early, were found to have prognostic significance. An eventually more severe disease was associated with a pattern of large joint involvement (shoulder, elbow, wrist, knee) and a pattern based on metatarsophalangeal joints I and III.
1094-153 Effects of surgical myectomy on myocardial energetics and blood flow in patients with hypertrophic cardiomyopathy and symptomatic left ventricular outflow obstruction
Authors: Stuart D Christenson, Panithaya Chareonthaitawee, Steve R Ommen, Rick A Nishimura, Brad J Kemp, A.Jamil Tajik, Raymond J Gibbons
Journal: Journal of the American College of Cardiology (2004)
Assuming the Worst
Authors: Ann-Marie Rosland
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal