Diagnosis of Pneumocystis Pneumonia by Induced Sputum Technique in Patients without the Acquired Immunodeficiency Syndrome
Authors: Henry Masur
Journal: Annals of Internal Medicine (1988)

Brief Reports1 November 1988Diagnosis of Pneumocystis Pneumonia by Induced Sputum Technique in Patients without the Acquired Immunodeficiency SyndromeHenry Masur, MD, Vee J. Gill, PhD, Frederick P. Ognibene, MD, James Shelhamer, MD, Cynthia Godwin, BS, Joseph A. Kovacs, MDHenry Masur, MD, Vee J. Gill, PhD, Frederick P. Ognibene, MD, James Shelhamer, MD, Cynthia Godwin, BS, Joseph A. Kovacs, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-9-755 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPneumocystis carinii pneumonia has gained notoriety in recent years for its role as the most commonly recognized cause of death in patients with the acquired immunodeficiency syndrome (AIDS). The management of pneumocystis pneumonia in patients with AIDS has been greatly enhanced in the past 3 years by the recognition that the diagnosis can be established rapidly and noninvasively by examining induced sputum samples: sensitivity of sputum examination in this patient population has increased from 55% to 92% in reported data (1-3). The specificity appears to be 100% at experienced laboratories (1-3).The literature before 1986 had suggested that examination of...References1. PitchenikGanjeiTorresEvansRubinBaier APADEH. Sputum examination for the diagnosis of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Am Rev Respir Dis. 1986;133:226-9. MedlineGoogle Scholar2. BigbyMargolskeeCurtis TDJ. The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Am Rev Respir Dis. 1986;133:515-8. MedlineGoogle Scholar3. KovacsNgMasur JVH. Diagnosis of Pneumocystis carinii pneumonia: improved detection in sputum with use of monoclonal antibodies. N Engl J Med. 1988;318:589-93. CrossrefMedlineGoogle Scholar4. WalzerPerlKrogstadRawsonSchultz PDDPM. Pneumocystis carinii pneumonia in the United States. Epidemiologic, diagnostic, and clinical features. Ann Intern Med. 1974;80:83-93. LinkGoogle Scholar5. LauYoungRemington WLJ. Pneumocystis carinii pneumonia. Diagnosis by examination of pulmonary secretions. JAMA. 1976;236:2399-402. CrossrefMedlineGoogle Scholar6. OgnibeneShelhamerGill FJV. The diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome using subsegmental bronchoalveolar lavage. Am Rev Respir Dis. 1984;129:929-32. MedlineGoogle Scholar7. KovacsHiemenzMacher JJA. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med. 1984;100:663-71. LinkGoogle Scholar8. KovacsGillSwan JVJ. Prospective evaluation of a monoclonal antibody for diagnosing Pneumocystis carinii pneumonia. Lancet. 1986;2:1-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the National Institutes of Health, Bethesda, Maryland. For current author addresses, see end of text. 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Clifford Lane, MD, Joseph A. Kovacs, MD, Carmen J. Allegra, MD, Jeffrey C. Edman, MDInduced sputum to diagnose Pneumocystis carinii pneumonia in immunosuppressed pediatric patientsClinical Studies of Pneumocystis carinii and Relationships to AIDSInfection in Relation to Thoracic Transplantation 1 November 1988Volume 109, Issue 9Page: 755-756KeywordsAIDSCritical carePneumocystisPneumocystis carinii pneumoniaPneumoniaResearch designSpecificitySputum Issue Published: 1 November 1988 PDF downloadLoading ...