tbuckley/cabot-search huggingface dataset:
Detection and Measurement of Occult Disease for the Prognosis of Solid Tumors
Authors: Tracy G. Lugo, Stephan Braun, Richard J. Cote, Klaus Pantel, Valerie Rusch
Journal: Journal of Clinical Oncology (2003)

Article Tools SPECIAL ARTICLES Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.01.153 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12829682 Detection and Measurement of Occult Disease for the Prognosis of Solid Tumors Tracy G. LugoxTracy G. LugoSearch for articles by this author , Stephan BraunxStephan BraunSearch for articles by this author , Richard J. CotexRichard J. CoteSearch for articles by this author , Klaus PantelxKlaus PantelSearch for articles by this author , Valerie RuschxValerie RuschSearch for articles by this author Show More From the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD; Universitaetsklinikum fuer Frauenheilkunde Leopold-Franzens-Universitaet, Innsbruck, Austria; University of Southern California, Keck School of Medicine, Los Angeles, CA; Universitatsklinikum Hamburg-Eppendorf, Hamburg, Germany; and Memorial Sloan-Kettering Cancer Center, New York, NY. https://doi.org/10.1200/JCO.2003.01.153 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Terms of service change is key to GPs' out of hours work
Authors: L Beecham
Journal: BMJ (1994)

The chairman of the General Medical Services Committee, Dr Ian Bogle, has admitted that the key to progress on general practitioners' out of hours work will be a change in the terms and conditions of service. He reported after the January meeting of the GMSC that he and the other negotiators were continuing discussions with lawyers and the Department of Health about how doctors could offer a consultation at a medically appropriate venue or arrange a hospital referral rather than have to offer a home visit. Dr Bogle hopes that sufficient progress will be made for him to be able to communicate with all doctors before the conference of local medical committees in June.

The GMSC chairman told a press conference that he believed that there was more support in the committee for a change in treatment venue provided that he could achieve a change in the terms of service. The ultimate aim was to ensure that doctors had the maximum choice for delivering out of hours care. The proposed primary care emergency centre was not the only solution, Dr Bogle said. More and more cooperatives were being set up and he and other committee members had visited some. At the GMSC meeting it was resolved that guidance on the development of cooperatives should be prepared for local medical committees and other interested parties.

The consultants appointed to assess all possible options for paying doctors to provide a new service have not yet met. But Dr Bogle said, The work will not go down, it will be done in …
The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: A retrospective multicentric GIMEMA experience
Authors: Luca Laurenti, Michela Tarnani, Ilaria Nichele, Stefania Ciolli, Agostino Cortelezzi, Francesco Forconi, Davide Rossi, Francesca Romana Mauro, Giovanni D'Arena, Giovanni Del Poeta, Marco Montanaro, Fortunato Morabito, Caterina Musolino, Vincenzo Callea, Lorenzo Falchi, Alessandra Tedeschi, Achille Ambrosetti, Gianluca Gaidano, Giuseppe Leone, Robin Foà
Journal: American Journal of Hematology (2011)

Although the coexistence of chronic lymphocytic leukemia (CLL) and myeloproliferative neoplasms (MPN) has been sporadically reported in the literature, no systematic studies on this disease association are available. We retrospectively analyzed 46 patients affected by CLL/MPN referred by 15 Italian GIMEMA centers. The aim of this retrospective multicenter study was to define the following: clinico-biological characteristics, possible familiarity, clinical course of both diseases, and influence of MPN chemotherapy on the course of CLL. Among 46 patients, 30 patients were males, 16 patients were females; median age was 71 years. Only one case had familiar CLL. Myeloproliferative disorders consisted of essential thrombocytemia in 18 cases, polycythemia vera in 10 cases, chronic myeloid leukemia in 9 cases, primary myelofibrosis in 6 cases, and MPN/myelodysplastic syndrome in 3 cases. The lymphoproliferative disorder was diagnosed as monoclonal B-cell lymphocytosis in 8 patients and as Binet Stage A CLL in 38 patients. After a median follow-up of 49 months, 9 patients experienced progressive CLL and only 6 patients required treatment after a median of 57.5 months. The biological profile confirmed a subset of low-risk CLL. Twenty patients received chemotherapy for MPN without influence on the course of CLL: lymphocyte counts remained unchanged after 3, 6, and 12 months of treatment. This series is the largest so far reported in literature. The diagnosis of concomitant CLL/MPN is a rare event and lymphoproliferative disorders present a clinical indolent course with a low-risk biological profile. MPN therapy does not interfere with the prognosis of patients with CLL.
Abstract 1550: Differential angiogenic roles of serum amyloid A 1 (SAA1) isoforms in esophageal squamous cell carcinoma (ESCC)
Authors: ON YING MAN, Maria Lung, Hong Lok Lung
Journal: Cancer Research (2014)

Abstract Esophageal Caner (EC), a highly metastatic and fatal cancer, is ranked the eighth in mortality rate in Hong Kong cancer patients (Hong Kong Cancer Registry, Hospital Authority, 2010). Esophageal Squamous Cell Carcinoma (ESCC) is the predominant type comprising more than 90% of EC. Using a functional complementation approach, SAA1 was identified as one of the tumor suppressor gene candidates. SAA1 is located at chromosome 11p15.1 and is expressed as a secretary protein in liver, human cultured smooth muscle cells, monocyte-macrophage cell lines, and in histologically-normal human epithelial tissues. Genetic polymorphisms of SAA1 have been identified as a risk factor of diseases such as amyloidosis. Three SAA1 isoforms with two single nucleotide polymorphisms at exon three (SAA1.1, 1.3, and 1.5) were observed in the ESCC patients and healthy individuals. The SAA proteins contain the functional YIGSR-like and RGD-like motifs, proteins with these motifs can inhibit angiogenesis, cell adhesion to ECM, growth and metastasis. To understand the anti-tumorigenic and anti-angiogenic roles of the three SAA1 isoforms in ESCC progression, both recombinant proteins and secreted proteins from the conditioned media of lentiviral-infected ESCC cell lines were used for functional assays. For the vascular endothelial cell tube formation assay, the treatments with SAA1.1 and 1.3 proteins showed suppression of tube formation, whereas no significant effects could be observed in the treatment with the SAA1.5. Suppression of cell proliferation and induction of cell death were observed when the endothelial cells were cultured with SAA1.1 and 1.3 proteins. To further elucidate the differential effects among the three SAA1 isoforms in anti-angiogenesis, the cytoskeleton arrangement of the vascular endothelial cells was studied. The SAA1.1 and SAA1.3 proteins could abolish the endothelial cell adhesion by disturbing the formation of stress fibers and focal adhesions. As a conclusion, the present data has shown the variation in anti-angiogenic potential of the three SAA1 isoforms. We acknowledge the financial support of the Food and Health Bureau of the Hong Kong Special Administration Region, China, grant number HMRF 01120886 to HLL. Citation Format: ON YING MAN, Maria Lung, Hong Lok Lung. Differential angiogenic roles of serum amyloid A 1 (SAA1) isoforms in esophageal squamous cell carcinoma (ESCC). [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1550. doi:10.1158/1538-7445.AM2014-1550
Uricosuric Action of Cholecystographic Agents
Authors: Gilbert H. Mudge
Journal: New England Journal of Medicine (1971)

The oral cholecystographic agents are highly lipid-soluble carboxylic acids. In this respect they resemble probenecid and some other uricosuric agents. Because of continuing case reports of nephrotoxicity of the gallbladder dyes, the possibility was raised that they have a uricosuric action. Ratios of uric acid to creatinine were determined in nine patients undergoing cholecystography with iopanoic acid, and in four during intravenous cholangiography with iodipamide. One volunteer was studied with ipodate. Each of these compounds was found to be uricosuric, with iopanoic acid having a potency approximately equivalent to probenecid. It is strongly recommended that adequate hydration be encouraged as a possible means of decreasing untoward renal complications during radiologic examination. On the basis of the present evidence, the uricosuric action cannot definitely be implicated as the mechanism of nephrotoxicity, but it may be a contributing factor.
Abstract 1315: CtIP is regulated by the APC/C-Cdh1 to mediate cell cycle-dependent control of DNA repair
Authors: Harmen R. de Boer, Lorenzo Lafranchi, Christine Neugebauer, Rudolf S.N. Fehrmann, Elisabeth G.E. de Vries, Alessandro A. Sartori, Marcel A.T.M. van Vugt
Journal: Cancer Research (2014)

Abstract Human cells have evolved elaborate mechanisms for responding to DNA damage to maintain genome stability and prevent carcinogenesis. For instance, the cell cycle can be arrested at different stages to allow time for DNA repair. The APC/C-Cdh1 ubiquitin ligase regulates mitotic exit but is also implicated in the DNA damage-induced G2 arrest. However, it is unknown whether APC/C-Cdh1 also directly participates in DNA repair. Here we show that depletion of Cdh1 in untransformed RPE-1 cells or several cancer cell lines results in increased levels of genomic instability as well as enhanced sensitivity to DNA double-strand break (DSB)-inducing agents. Moreover, Cdh1 depletion results in aberrant homology-directed repair. Using an integrated SILAC proteomics and bioinformatics approach in RPE-1 cells, we identified CtIP as a novel APC/C-Cdh1 target. CtIP interacts with Cdh1 through a conserved KEN box, of which mutation prevents CtIP ubiquitination and impedes CtIP down-regulation both during G1 and after DNA damage in G2. Importantly, the inability of CtIP to interact with Cdh1 causes defective homology-directed repair. Combined, these results show that APC/C-Cdh1 safeguards genome integrity by controlling CtIP stability in a cell cycle- and DNA damage-dependent manner. Supported by European Research Councel grant -2011-293445; Dutch Cancer Society grant RUG-2011-5093; the Vontobel Stiftung and Swiss National Science Foundation grant 31003A_135507. Citation Format: Harmen R. de Boer, Lorenzo Lafranchi, Christine Neugebauer, Rudolf S.N. Fehrmann, Elisabeth G.E. de Vries, Alessandro A. Sartori, Marcel A.T.M. van Vugt. CtIP is regulated by the APC/C-Cdh1 to mediate cell cycle-dependent control of DNA repair. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1315. doi:10.1158/1538-7445.AM2014-1315
Mucoepidermoid Carcinoma of the Esophagus: Report of Two Cases and Review of the Literature
Authors: K. Sasajima, M. Watanabe, K. Takubo, A. Takai, K. Yamashita, M. Onda
Journal: Endoscopy (1990)

The clinicopathological manifestation of mucoepidermoid carcinoma of the esophagus are reported in two cases. Barium swallow and endoscopy revealed infiltrating and constricting appearances. The tumors were grossly indurated, with or without ulceration. Histologically, the tumors were composed of a mixture of glandular cells which contained signet ring cells and squamous cells. In two cases, the tumor cells invaded into the adventitia, with lymph node metastasis. Two patients died of widespread metastasis within 1 year after operation.
The treatment burden and families' rights
Authors: T. Jackson
Journal: BMJ (2014)

We hear much these days about how health systems and those who work in them are under unprecedented strain. In the United Kingdom, general practitioners are said to be feeling overwhelmed, hospital waiting lists are rising, and policy makers and the public face difficult questions about how to fund an NHS whose services are increasingly in demand. But as well as caregivers, patients—particularly those with multimorbidity—are feeling the demands made by healthcare systems. This is the burden of treatment, which Frances S Mair and Carl R May discuss in an editorial this week (doi:10.1136/bmj.g6680).

As they write, “The burden continues to increase as healthcare …
Surgery and Neurodevelopmental Impairment
Authors: Dany E. Weisz, Lucia Mirea, Prakesh S. Shah
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Routine protective isolation: Worth the trouble in neutropenic patients?
Authors: William Golden
Journal: JAMA (1979)

Routine protective isolation procedures for granulocytopenic patients may not offer any more protection from infections than general ward care, according to results of a prospective study at the University of Wisconsin Center of Health Sciences, Madison. William M. Nauseef, MD, now a fellow in infectious diseases at Yale-New Haven Hospital, Conn, and coinvestigator Dennis G. Maki, MD, associate professor of medicine at Wisconsin, randomly assigned 37 neutropenic patients—most with a diagnosis of acute nonlymphocytic leukemia—to standard ward accommodations or private rooms with reverse isolation precautions. Protective isolation procedures entailed the usual gown, mask, and glove requirements for all visitors. The only modification of care given the ward patients was handwashing prior to patient contact. Moreover, the ward group was sent for diagnostic studies throughout the hospital without special precautions. Neither group received nonabsorbable antibiotics, sterilized food, or cutaneous disinfectants. Both were given the same antineoplastic therapy and supportive care. Surveillance
Physiologic Basis of Premature Beats and Sustained Tachycardias
Authors: Gordon K. Moe, Carlos Mendez
Journal: New England Journal of Medicine (1973)

ONLY two mechanisms are involved in the genesis of a wide variety of disorders of cardiac rhythm ranging from isolated premature beats to self-sustained, rapid, and potentially lethal cardiac arrhythmias: impulse generation in an ectopic focus, or reentry (i.e., a "circus movement"). Both re-entry and ectopic automatic foci can be demonstrated experimentally, and both are possible in the clinical situation. Although in patients it may be exceedingly difficult to decide which of the two is responsible for a particular disturbance in cardiac rhythm, this distinction has practical consequence. The rational use of pharmacologic agents or electrical devices (or both) in . . .
Acute-Onset Floaters and Flashes
Authors: Hussein Hollands, Davin Johnson, Anya C. Brox, David Almeida, David L. Simel, Sanjay Sharma
Journal: JAMA (2009)

Posterior vitreous detachment is a common age-related condition typically presenting as acute-onset floaters and flashes of lightPosterior vitreous detachment is the most common cause of acute-onset floaters or flashes of light.Its prevalence is 24% among adults aged 50-59 years, increasing to 87% among people older than 80 years. 1 Posterior vitreous detachment, retinal tear and retinal detachment are a spectrum of diseaseIn posterior vitreous detachment, the vitreous shrinks and detaches from the retina leading to symptoms of floaters and/or flashes.In 14% of cases, tractional forces from the vitreous jelly on the retina cause a full-thickness retinal tear. 2 Left untreated, retinal tears allow fluid to enter the subretinal space (between the retina and choroid) and can progress to a retinal detachment and possible blindness (see image in Appendix 1,
Increased Expression of Connexin 43 in the Overactive Neurogenic Detrusor
Authors: A. Haferkamp, J. Mundhenk, P.J. Bastian, A. Reitz, J. Dörsam, J. Pannek, S. Schumacher, B. Schurch, R. Büttner, S.C. Müller
Journal: European Urology (2004)
Screening for Hepatitis C Virus Infection in Adults: Recommendation Statement
Journal: Annals of Internal Medicine (2004)

This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for hepatitis C virus (HCV) infection, which are based on the USPSTF's examination of evidence specific to asymptomatic persons for HCV testing and treatment. The complete information on which this statement is based, including evidence tables and references, is available in the accompanying article in this issue and in the summary of the evidence and systematic evidence review on this topic. The complete USPSTF recommendation statement (which includes a brief review of the supporting evidence), the accompanying journal article, and the complete systematic evidence review are available through the USPSTF Web site (www.preventiveservices.ahrq.gov). The journal article and the USPSTF recommendation statement are available in print through the Agency for Healthcare Research and Quality Publications Clearinghouse (telephone, 800-358-9295; e-mail, ahrqpubs@ahrq.gov). *For a list of the members of the U.S. Preventive Services Task Force, see the Appendix.
Time to rethink aspirin in diabetes?
Authors: S. H Song, T. A Gray, S. Tesfaye
Journal: BMJ (2009)

De Berardis and colleagues’ meta-analysis adds to the growing uncertainty about the role of aspirin in preventing cardiovascular disease in diabetes.1

Despite lack of definitive randomised controlled trial evidence, various guidelines advocate routine use of aspirin on the assumption that diabetic subjects without vascular disease will experience the same clinically …
A CASE OF CEPHALIC TETANUS, WITH PARALYSIS OF BOTH SEVENTH NERVES.
Authors: JAMES HENDRIE LLOYD
Journal: JAMA (1905)

In 1870, Rose<sup>1</sup>described a rare form of tetanus in which the tetanic symptoms were sometimes (but not always) confined to the muscles of the jaw and throat and were associated with a paralysis of the seventh nerve. This paralysis of the seventh nerve may be said to be the most distinguishing symptom of this form of lockjaw, and the cases thus far reported have, without exception, arisen from wounds in the territory of the fifth nerve. Although paralysis of the seventh nerve is the most characteristic symptom, this nerve is not the only one paralyzed in all cases, for in very few instances the motor nerves of the eye, the hypoglossal nerve, and the branches of the pneumogastric nerve supplying the muscles of the pharynx, have also been involved. Such an anomaly as these local palsies present in cases of lockjaw could not fail in time to attract
Will Payment Based on Diagnosis-Related Groups Control Hospital Costs?
Authors: John E. Wennbero, Klim McPherson, Philip Caper
Journal: New England Journal of Medicine (1984)

Previous studies have shown that the admission rates for a few surgical procedures, such as hysterectomy, vary extensively among hospital market areas, apparently because of differences in physicians' practice styles. To see whether such variations occur for most causes of admission, we classified all nonobstetrical medical and surgical hospitalizations in Maine for the years 1980 through 1982 into diagnosis-related groups (DRGs) and measured the variations in admission rates among 30 hospital market areas. Hysterectomy rates varied 3.5-fold, but 90 per cent of medical and surgical admissions fell into DRGs for which admission rates were even more variable, suggesting that professional discretion plays an important part in determining hospitalization for most DRGs. Losses in hospital revenues resulting from the DRG payment system could be offset if physicians modified their admission policies to produce more profit, well within the current limits of medical appropriateness. If this occurred, the net effect of a DRG program would be to exacerbate hospital cost inflation. We conclude that, to be successful, cost-containment programs based on fixed, per-admission hospital prices will need to ensure effective control of hospitalization rates.
Timely administration of AICA riboside reduces reperfusion injury in rabbits
Authors: J. G Kingma, D. Simard, J. R Rouleau
Journal: Cardiovascular Research (1994)

Objective: Agents which promote increased interstitial adenosine levels may be cardioprotective. The aim of this study was to evaluate the ability of 5-amino-1-β-D-ribofuranosylimidazole-4-carboxamide (AICAr), an adenosine regulating agent, to limit infarct size when given before ischaemia, before coronary reperfusion, or postreperfusion in a rabbit preparation of ischaemia-reperfusion injury. Methods: The left coronary artery was occluded for 30 min and subsequently the ischaemic bed was reperfused for 180 min. Infarct size and risk zone size were delineated by tetrazolium staining and microsphere autoradiography, respectively. Four groups were studied: controls (n = 13), AICAr (2.5 mg·kg−1·min−1 intravenously for 5 min followed by 0.5 mg·kg−1·min−1 for 60 min) beginning either 5 min before coronary occlusion (n = 11), 5 min before coronary reperfusion (n = 11), or at 25 min coronary reperfusion (n = 10). Lignocaine was not given in these experiments. Results: Infarct size, normalised to risk zone, was significantly reduced with AICAr given 5 min before coronary reperfusion, at 35.0(SEM 4.4)% v 51.8(3.9)% in controls; p = 0.03. Cardioprotection was not observed when AICAr was given either 5 min before coronary occlusion [44.2(4.8)%] or 25 min postreperfusion [45.9(3.2)%]. Conclusions: These findings support the hypothesis that adenosine regulating agents, such as AICAr, can modulate infarct size in this rabbit preparation of ischaemia-reperfusion injury. Cardiovascular Research 1994;28:1003-1007