tbuckley/cabot-search huggingface dataset:
Thrombolysis is an effective and safe therapy in stuck bileaflet mitral valves in the absence of high-risk thrombi
Authors: Yaron Shapira, Itzhak Herz, Mordehay Vaturi, Avital Porter, Yehuda Adler, Yochai Birnbaum, Boris Strasberg, Samuel Sclarovsky, Alex Sagie
Journal: Journal of the American College of Cardiology (2000)
Penetration of Ofloxacin into Heart Valves, Myocardium, Mediastinal Fat and Sternal Bone Marrow in Man
Authors: P.M. Mertes, F. Jehl, P. Burtin, C. Dopff, G. Pinelli, J.P. Villemot, M. Monteil, J.B. Dureux
Journal: Drugs (1993)
Abstract 1742: Evaluating the prognostic value of EGFR by p16/HPV status in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiation
Authors: Desirée Hao, Harold Y. Lau, Michael Eliasziw, Alexander C. Klimowicz, Keiko Suzuki, Stephanie K. Petrillo, Alan Box, Roman Diaz, Alice Banh, Quynh-Thu Le, Anthony M. Magliocco
Journal: Cancer Research (2010)

Abstract Background: Overexpression of the epidermal growth factor receptor (EGFR) has been correlated with a worse prognosis in patients with squamous cell carcinoma of the head and neck (SCCHN), however the prognostic value of EGFR has not been fully evaluated in the context of human papillomavirus (HPV) status. Methods: Records from 91 consecutive SCCHN patients treated with concurrent chemoradiation at the Tom Baker Cancer Centre between August 2000 and March 2005 were reviewed. Triplicate 0.6 mm cores from available pre-treatment formalin-fixed paraffin-embedded (FFPE) biopsies were assembled into a tissue microarray. Immunofluorescence combined with automated quantitative analysis (AQUA™) was used to evaluate EGFR and p16 protein expression. Phosphorylated EGFR (pEGFR) was assessed by proximity ligation assay. HPV infection status was determined by colorimetric in-situ hybridization using the INFORM HPV Family 16 Probe (CISH). PCR was used to detect HPV DNA. EGFR and pEGFR were correlated with clinical outcomes according to p16-status and HPV-status. Results: FFPE biopsies were available from 49 patients (54%). Patient characteristics were as follows: mean age 55 years, 82% male, 49% oropharyngeal primaries. The complete response rate was 88%. With a median follow-up of 42 months (range 3 to 60), the 5 year overall survival (OS) was 54%. EGFR and pEGFR protein expression were classified as high in 14 (29%) and 13 (27%) tumours respectively. 27 tumours were p16 positive; 30 were HPV positive by either PCR or CISH. p16 was strongly correlated with HPV status (Spearman r=0.80). In univariate analyses, tumours with high EGFR, low p16, and HPV negative were associated with significant 3-, 7-, and 5-fold increases, respectively, in locoregional recurrence, recurrence at any site, disease-specific mortality and worse OS. pEGFR did not predict outcome. Neither EGFR nor pEGFR predicted response. After adjusting for age, smoking status, T- and N-stage, p16, and HPV there was no relationship between EGFR and outcome. p16 and EGFR were inversely related (Spearman r=-0.3). Conclusions: In our small cohort of patients, EGFR did not have prognostic value after correction for p16 / HPV status. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1742.
Blood Dycrasias and Hematologic Reactions in Ticlopidine Users
Authors: Diane K. Wysowksi
Journal: JAMA (1996)

To the Editor.  —Ticlopidine hydrochloride (Ticlid, Roche Laboratories, Nutley, NJ) is an antiplatelet drug that has been marketed in the United States since October 1991. Based on reports since then, the labeling of ticlopidine has been changed. Ticlopidine is indicated to reduce the risk of thrombotic stroke in patients who have experienced stroke precursors or had a completed stroke, and it should be reserved for patients who are intolerant of aspirin therapy indicated to prevent stroke. The product labeling as approved in 1991 included a boxed warning that states neutropenia occurred in 2.4% and severe neutropenia and/or agranulocytosis occurred in 0.8% of stroke patients who received ticlopidine in premarketing clinical trials. Reports in the medical literature suggest that ticlopidine may also be associated with aplastic anemia and thrombotic thrombocytopenic purpura. 1-3 In a preliminary worldwide search of adverse hematologic events associated with ticlopidine through 1994, a total of 645 cases
24. Widespread and Efficient Gene Delivery to the Heart and Liver Using AAV Serotype 9: Implications for Cardiovascular Disease and Hemophilia
Authors: Thierry VandenDriessche, Lieven Thorrez, Abel Acosta-Sanchez, Lilly Wang, Veerle Gillijns, Ma Ling, Herman Vandenburgh, Nico Mertens, Nico Callewaert, James Wilson, Desire Collen, Marinee Chuah
Journal: Molecular Therapy (2006)

Heart disease remains one of the most prominent health challenges. Gene therapy may provide an alternative treatment to attain functional correction of the damaged heart. However, gene delivery into the heart has been particularly challenging which was least partly due to the inability to achieve widespread gene transfer following localized intra-cardiac delivery of gene transfer vectors, which typically remain confined to the injection site. The present study shows that a single intravenous injection of an adeno-associated viral vector derived from the human serotype 9 (AAV9) resulted in unprecedented and widespread transduction of the heart in adult mice. Almost the entire heart was GFP positive as up to 90% of the cardiomyocytes were predominantely transduced. Transduction efficiency was far greater than with any other gene delivery system described so far, including lentiviral and HC-Ad vectors, and obviated the use of neonatal recipients or the need for pharmacologic intervention to enhance vector penetration into the heart tissue. The use of AAV9 was not associated with any apparent side-effects, consistent with the lack of immune complications or pro- inflammatory cytokine induction (IL-6, TNF) following gene delivery. Moreover, AAV9 also resulted in highly efficient gene transfer into the liver paving the way towards improved gene therapeutics for liver disease and for production of therapeutically relevant proteins that are secreted into the circulation. As proof-of- concept, an AAV9 vector encoding human clotting factor IX (FIX) was generated and injected into hemophilia B mice. This resulted in stable therapeutic levels of factor IX (100 μg/ml, i.e. 20-fold higher than normal levels) which far exceeded levels obtained using the prototypical AAV2 serotype that has been used previously in clinical trials. No neutralizing antibodies against transgene-endoded FIX could be detected. Hepatic FIX expression may provide an attractive alternative to ectopic FIX expression (e.g. in muscle), which we showed resulted in abnormal post-translational glycosylations and impaired propeptide cleavage of the transgene-encoded FIX protein . The present study identifies a highly efficient and safe means to deliver genes to the heart and liver using AAV9, which may overcome the current challenges that hamper progress to treat genetic or acquired heart disease and bleeding disorders. Moreover, the use of AAV9 opens up a new platform technology for screening or validating promising new therapeutic leads or for the rapid generation of animal models of human heart disorders that could be used to validate new pharmacologic agents.
Resolution of salmonella carriage after duodenoscopic treatment for a common bile duct stone.
Authors: A Forbes, P B Cotton
Journal: BMJ (1984)

three patients in group 1 and in none of the patients in group 2. Oral phenoxybenzamine given during epidural analgesia was not associated with hypotension or with any other untoward effect. CommentThis patient was a chronic carrier of S eastbourne despite a cholecystectomy 18 years previously.This appeared to be resistant to appropriate antibiotics until a common bile duct stone was removed.Salmonella carriage was probably perpetuated by biliary stasis analogous to that caused by a stone filled gall bladder.We thank Dr J Partridge for his help in arranging analysis of stool samples.
Polyethylene Glycol/Surfactant Mixtures Improve Lung Function after HCl and Endotoxin Lung Injuries
Authors: KAREN W. LU, H. WILLIAM TAEUSCH, BENGT ROBERTSON, JON GOERKE, JOHN A. CLEMENTS
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Addition of nonionic polymers such as polyethylene glycol (PEG) and dextran ameliorates inactivation of Survanta by a variety of substances in vitro. Addition of polymers to Survanta also improves pulmonary function when used to treat rats with lung injury caused by instillation of human meconium. To find whether this approach is effective in lung injuries that more closely resemble adult respiratory distress syndrome (ARDS), we have compared the use of Survanta with Survanta + PEG in two additional models of lung injury caused by either lipopolysaccharide (LPS) or HCl in adult rats. Significant improvement of serial measures for arterial oxygenation and of postmortem pressure–volume measurements were found after treatment with Survanta + PEG compared with Survanta alone. PEG added to Survanta increased resistance to inactivation caused by tracheal fluid taken from animals injured with HCl. Other work suggests that PEG promotes surfactant aggregation, separates surfactant from surfactant inhibitors, and enhances access of surfactant to the gas–liquid interface. The addition of polymers to surfactants may also be useful in the treatment of lung injury where inactivation of surfactant has already occurred.
Subcutaneous Human C1-Inhibitor with Recombinant Human Hyaluronidase for the Prevention of Angioedema Attacks in Patients with Hereditary Angioedema: Results of a Randomized, Double-Blind, Dose-Ranging, Crossover Study
Authors: Marc A. Riedl, William R. Lumry, H. Henry Li, Aleena Banerji, Jonathan A. Bernstein, Murat Bas, Markus Magerl, Marcus Maurer, Hongzi Chen, Jennifer Schranz
Journal: Journal of Allergy and Clinical Immunology (2015)
p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis
Authors: Subha Krishnan, Raghuveer Singh Mali, Baskar Ramdas, Emily Sims, Peilin Ma, Joydeep Ghosh, Veerendra Munugalavadla, Philip Hanneman, Joal D. Beane, Reuben Kapur
Journal: Blood (2012)
Thyroid autoimmunity and pemphigus vulgaris: Is there a significant association?
Authors: Maryam Daneshpazhooh, Javad Behjati, Pantea Hashemi, Safar Shamohammadi, Hossein Mortazavi, Mohammad-Javad Nazemi, Mohammad-Reza Kiani, Cheyda Chams-Davatchi
Journal: Journal of the American Academy of Dermatology (2010)
Liver transplantation in HIV-HCV coinfected patients. New indication and preliminary experience
Authors: Didier Samuel, Cyrille Feray, Daniel Vittecoq, Daniel Azoulay, Elena Teicher, Fawzi Saliba, Philippe Ichai, Anne Marie Roque, Denis Castaing, Rene Adam, Elisabeth Dussaix, Catherine Guettier, Henri Bismuth
Journal: Journal of Hepatology (2002)
Neuronal deactivation is equally important for understanding emotional processing
Authors: Jacob M. Vigil, Amber Dukes, Patrick Coulombe
Journal: Behavioral and Brain Sciences (2012)

Abstract In their analyses of the neural correlates of discrete emotionality, Lindquist et al. do not consider the numerous drawbacks to inferring psychological processes based on currently available cognitive neurometric technology. The authors also disproportionately emphasize the relevance of neuronal activation over de activation, which, in our opinion, limits the scope and utility of their conclusions.
Racial differences in effectiveness of α-fetoprotein for diagnosis of hepatocellular carcinoma in hepatitis C virus cirrhosis
Authors: Mindie H. Nguyen, Ruel T. Garcia, Peter W. Simpson, Teresa L. Wright, Emmet B. Keeffe
Journal: Hepatology (2002)

α-Fetoprotein (AFP) is frequently used as a diagnostic marker for hepatocellular carcinoma (HCC). Most available data concerning AFP come from studies of patients with chronic hepatitis B or other chronic liver diseases of mixed etiologies. Limited data concerning the diagnostic value of AFP for hepatitis C virus (HCV)-related HCC have to date come only from Asian and European studies, and results are conflicting. There may be significant differences in AFP levels depending on racial backgrounds and etiologies of primary liver disease. We conducted a multicenter, retrospective, case-control study of 163 HCC patients with HCV infection and 149 control patients with HCV-related cirrhosis. The positive likelihood ratios for AFP at 0 to 20, 21 to 50, 51 to 100, and 101 to 200 ng/mL were 0.46, 1.31, 1.15, and 6.90, respectively. No controls had AFP greater than 200 ng/mL. The sensitivity of AFP for the diagnosis of HCC in African Americans with HCV infection was lower than that of patients of all other ethnic groups combined (57.1% vs. 81.6% for AFP &gt; 10 ng/mL, P = .02, and 42.9% vs. 66.0% for AFP &gt; 20 ng/mL, P = .05). The area under the receiver operating characteristics curve was 0.81 for non-African Americans but only 0.56 for African Americans. In conclusion, AFP greater than 200 ng/mL can be used to confirm HCC in patients with HCV-related cirrhosis and a hepatic mass. However, AFP is insensitive for the diagnosis of HCC in African Americans.
Oral trimethoprim versus oxytetracycline in the treatment of inflammatory acne vulgaris
Authors: J.R. GIBSON, C.R. BARLEY, S.G. HARVEY, J. EARTH
Journal: British Journal of Dermatology (1982)

Journal Article Oral trimethoprim versus oxytetracycline in the treatment of inflammatory acne vulgaris Get access J.R. GIBSON, J.R. GIBSON Skin Department, The London Hospital, Whitechapel, London Dr John R. Gibson, The Skin Department, The London Hospital, Whitechapel, London E1 1BB. Search for other works by this author on: Oxford Academic Google Scholar C.R. BARLEY, C.R. BARLEY Skin Department, The London Hospital, Whitechapel, London Search for other works by this author on: Oxford Academic Google Scholar S.G. HARVEY, S.G. HARVEY Skin Department, The London Hospital, Whitechapel, London Search for other works by this author on: Oxford Academic Google Scholar J. EARTH J. EARTH Skin Department, The London Hospital, Whitechapel, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 2, 1 August 1982, Pages 221–224, https://doi.org/10.1111/j.1365-2133.1982.tb00342.x Published: 01 August 1982 Article history Accepted: 30 October 1981 Published: 01 August 1982
Risk factors for pancreatitis.
Authors: A S Mee, M Bower
Journal: Gut (1997)

<b>Introduction:</b> Levamisole modulates immune response in tuberculosis (TB) and may help achieve the aims of TB control by reducing morbidity and cutting the chain of transmission. <b>Aims and Objectives:</b> To assess efficacy by sputum smear and culture conversion and improvement in patients of pulmonary and extra-pulmonary drug-resistant (DR) [including Multi-drug resistant (MDR) and Extensively-drug resistant(XDR)] TB receiving Levamisole along with anti-TB drug therapy and observe the safety profile of levamisole. <b>Methods:</b> In this prospective experimental case-control study, a total of 200 patients of DR TB were stratified into 3 groups: 1. Pulmonary(<i>n</i>=142) 2. Extra-pulmonary(<i>n</i>=43) 3. Pulmonary &amp; Extra-pulmonary(<i>n</i>=15) and further randomized by computer allocation to 2 arms: 1. Cases(<i>n</i>=89), receiving Levamisole thrice weekly along with individualized regimens of daily anti-TB therapy and 2. Controls(<i>n</i>=111), receiving daily anti-TB therapy for a total of 90 days. Treatment was partly supervised to ensure compliance. Sputum smear and culture conversion and clinical and radiological improvement were compared at baseline and 90 days, the results being analyzed by Fisher’s (two-tailed) exact test. <b>Results:</b> Sputum conversion was better (<i>p</i>=0.0011) in cases (60/71) than controls (54/86). Clinical and radiological improvement was better (<i>p</i>=0.0001) in cases (82/89) than controls (62/111). Gastritis was more common (<i>p</i>=0.013) in cases (27/89) than controls (19/111). <b>Conclusion:</b> Levamisole along with anti-TB therapy in patients of drug resistant tuberculosis led to significantly better sputum conversion and improvement in comparison to anti-TB therapy alone with acceptable adverse effects (gastritis).
Evangelists and Snails
Authors: David Atkins
Journal: Annals of Internal Medicine (1996)

Letters15 December 1996Evangelists and SnailsDavid Atkins, MD, MPH, Carolyn DiGuiseppi, MD, MPH, and Douglas B. Kamerow, MD, MPHDavid Atkins, MD, MPHDepartment of Health and Human Services, Rockville, MD 20852.Search for more papers by this author, Carolyn DiGuiseppi, MD, MPHDepartment of Health and Human Services, Rockville, MD 20852.Search for more papers by this author, and Douglas B. Kamerow, MD, MPHDepartment of Health and Human Services, Rockville, MD 20852.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-12-199612150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As staff to the U.S. Preventive Services Task Force [1], we second Dr. Davidoff's observations on “evangelists” and “snails” [2]. We also note a related factor in the cholesterol debate: Proponents of screening point to the potential benefits to an individual patient under ideal circumstances (that is, efficacy), whereas evidence-based panels such as the U.S. Preventive Services Task Force, the American College of Physicians, and the Canadian Task Force on the Periodic Health Examination require proof of important net benefits in the real world (that is, effectiveness). Thus, the substantial cholesterol reductions obtained with specialized interventions in ...References1. U.S. Preventive Services Task Force. Guide to Clinical Preventive Services. 2d ed. Baltimore: Williams & Wilkins; 1996. Google Scholar2. Davidoff F. Evangelists and snails redux: the case of cholesterol screening [Editorial]. Ann Intern Med. 1996; 124:513-4. Google Scholar3. Ammerman A, Caggiula A, Elmer PJ, Kris-Etherton P, Keyserling T, Lewis C, et al. Putting medical practice guidelines into practice: the cholesterol model. Am J Prev Med. 1994; 10:209-16. Google Scholar4. LaRosa JC. Cholesterol agonistics. Ann Intern Med. 1996; 125:505-8. Google Scholar5. Robertson I, Phillips A, Mant D, Thorogood M, Fowler G, Fuller A, et al. Motivational effects of cholesterol measurement in general practice health checks. Br J Gen Practice. 1992; 42:469-72. Google Scholar Author, Article, and Disclosure InformationAffiliations: Department of Health and Human Services, Rockville, MD 20852. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1996Volume 125, Issue 12Page: 1011-1012KeywordsCholesterolDietFatsHealth screeningHypercholesterolemiaLipidsMedical risk factorsPopulation statisticsVascular diseasesYoung adults Issue Published: 15 December 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract 2467: Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis <i>in vivo</i>
Authors: Qing C. Shao, Mark Jake Ableser, Silvia Penuela, Dale W. Laird
Journal: Cancer Research (2014)

Abstract Gap junctions formed from connexins (Cx) have been reported to regulate proliferation, differentiation and apoptosis through formation of intercellular channels between opposing cells. Interestingly, connexins have been identified as tumor suppressors and enhancers, a distinction dependent on the type and stage of disease. In melanomas, the role of connexins during cancer onset and progression remains unclear. In the current study, we hypothesize that expression of Cx26 and Cx43 in BL6 mouse melanomas will increase gap junctional intercellular communication (GJIC) thereby decrease their tumorigenic properties. Western blots, immunofluorescence and dye coupling studies revealed that BL6 cells express low levels of Cx26 , Cx43 and are poorly coupled. When cells were engineered to express Cx26 or Cx43, dye transfer studies revealed that both Cx26- and Cx43-expressing cells were highly coupled. Interestingly, when these connexin-rich melanomas were co-cultured with Cx43-rich keratinocytes, melanoma microtumors remained functionally isolated and failed to couple to surrounding keratinocytes. Growth curve studies revealed that exogenous Cx43, but not Cx26, significantly reduced total cell numbers; that was primarily due to reduced cell proliferation. Furthermore, Cx43 expression significantly reduced anchorage-independent growth compared to controls, however, migration remained unaffected. Additionally, Cx43-expressing melanoma cells displayed a reduction in growth when co-cultured with keratinocytes, despite a lack of heterocellular GJIC. Finally, when grown in in vivo avian embryo model, primary tumor weight was reduced in tumor cells expressing Cx43 , but not in Cx26-expressing melanomas , as compared to controls. Overall, our results would suggest that Cx43 is a potent tumor suppressor in melanomas. Supported by the Canadian Institute of Health Research to DWL. Citation Format: Qing C. Shao, Mark Jake Ableser, Silvia Penuela, Dale W. Laird. Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2467. doi:10.1158/1538-7445.AM2014-2467
Prevention of Stress-Induced Ulcer in the Rat by Gastric Freezing
Authors: Arthur S. McFee, Nelson H. Stone, Robert L. Goodale, Eugene F. Bernstein, Owen H. Wangensteen
Journal: JAMA (1963)

GASTRIC FREEZING has been developed in " an effort to reduce ulcerogenesis dependent on secretory hyperactivity in man and other animals. In man, we have observed marked secretory depression and healing of ulcer craters following gastric freezing.<sup>1,2</sup>In experimental animals, the incidence of ulcer provocation induced by histamine or by gastrin stimulation has been reduced considerably by gastric freezing. Reduction of secretory volume as a result of freezing also has been noted in the rabbit's appendix. The purpose of this study is to demonstrate that gastric freezing can greatly diminish the incidence of stress-induced ulcer in the rat. The stomach of the rat is divided into two segments, a proximal squamous nonsecreting portion, the rumen, and a distal gastric mucosal stomach which contains the gastric secretory and mucus cells and the antrum. Several procedures have been developed which produce ulcers in both portions of this stomach. Prior freezing of the
Spectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization
Authors: Talisa E. de Carlo, Marco A. Bonini Filho, Adam T. Chin, Mehreen Adhi, Daniela Ferrara, Caroline R. Baumal, Andre J. Witkin, Elias Reichel, Jay S. Duker, Nadia K. Waheed
Journal: Ophthalmology (2015)
Carotid Cavernous Sinus Fistula Closure Following Angiography
Authors: Donald R. Bennett
Journal: JAMA (1973)

Closure of a carotid cavernous sinus fistula occurred following angiography. Although previous reports of similar events have suggested that carotid artery compression, irritating and vasoconstrictor effects of radiopaque media, or embolization might explain the closure, these mechanisms seemed unlikely here. There is a possibility that hypotension was the primary cause for closure.