tbuckley/cabot-search huggingface dataset:
Well-woman Clinics--Yes or No?
Authors: R. Burkitt
Journal: BMJ (1974)

<h3>Background</h3> The therapeutic armamentarium of bladder cancer has been recently enriched with the introduction of new therapies including immune checkpoint inhibitors, receptor tyrosine kinase inhibitors and antibody drug conjugates, however treatment responses and duration of responses are still less than expected. Adoptive cellular therapy (ACT) using tumor-infiltrating lymphocytes (TILs) has potential to treat bladder cancer, as previously demonstrated by successful expansion of tumor reactive T cells from human bladder tumors. <h3>Methods</h3> A model system using OT-I T cells and an ovalbumin expressing MB49 tumor cell line (MB49OVA) was developed to study ACT in bladder cancer. Systemic ACT-treated mice were given T cells intravenously after lymphodepleting chemotherapy and followed by interleukin (IL)-2 administration. Intravesical ACT treated mice were given T cells directly into the bladder, without chemotherapy or IL-2. TILs were isolated from MB49 orthotopic tumors and expanded ex vivo in IL-2. Immune cell infiltrates were analyzed by flow cytometry. T cell infiltration was studied using a CXCR3 blocking antibody. <h3>Results</h3> Systemic ACT-treated mice had a decrease in tumor growth, increase in T cell infiltration and long-term immune protection compared with control-treated mice. OT-I T cells delivered intravesically were able to control tumor growth without lymphodepleting chemotherapy or IL-2 in MB49OVA orthotopic tumors. Intravesical delivery of TIL expanded from MB49 tumors was also able to decrease tumor growth in mice with MB49 orthotopic tumors. Blocking CXCR3 on OT-I T cells prior to intravesical delivery decreased T cell infiltration into the tumor and prevented the control of tumor growth. <h3>Conclusions</h3> This study demonstrates how TIL therapy can be used in treating different stages of bladder cancer.
Dangers of sunbeds are greater in the commercial sector
Authors: A. Wright, G. Hart, L. Kernohan
Journal: BMJ (1997)

Editor—We have studied the ultraviolet light output of ultraviolet A sunbeds available for hire in Bradford and found a striking variability in the output of both ultraviolet A and ultraviolet B.1 Results from the analysis of the 50 sunbeds studied showed a threefold variation in ultraviolet A output with a mean output of 13.5 mW/cm2 and a 60-fold variation with a mean of 19.2 µW/cm2 for ultraviolet B. …
The Identification of Nitric Oxide as Endothelium-Derived Relaxing Factor
Authors: Joseph Loscalzo
Journal: Circulation Research (2013)

The identification of endothelium-derived relaxing factor as nitric oxide (NO) dramatically altered the course of vascular biology, as well as other biomedical disciplines. The ubiquity of this natural product of cell metabolism and the complexity of its biochemistry provide a rich source of molecular mediators of phenotype in health and disease.
Itching following burns: epidemiology and predictors
Authors: N.E.E. Van Loey, M. Bremer, A.W. Faber, E. Middelkoop, M.K. Nieuwenhuis
Journal: British Journal of Dermatology (2007)

Journal Article Itching following burns: epidemiology and predictors Get access N.E.E. Van Loey, N.E.E. Van Loey Association of Dutch Burns Centres, PO Box 1015, 1940 EA Beverwijk, The Netherlands Correspondence: Nancy Van Loey. E‐mail: nvanloey@burns.nl Search for other works by this author on: Oxford Academic Google Scholar M. Bremer, M. Bremer Martini Hospital, PO Box 30333, 9700 RM Groningen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar A.W. Faber, A.W. Faber Martini Hospital, PO Box 30333, 9700 RM Groningen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar E. Middelkoop, E. Middelkoop Association of Dutch Burns Centres, PO Box 1015, 1940 EA Beverwijk, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar M.K. Nieuwenhuis, M.K. Nieuwenhuis Search for other works by this author on: Oxford Academic Google Scholar The Research Group The Research Group Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 1, 1 January 2008, Pages 95–100, https://doi.org/10.1111/j.1365-2133.2007.08278.x Published: 01 January 2008
Reply to the Letter to the Editor on ‘Cost-opportunity analysis in clinical oncology: from the “wild far-west” to a correct integration of the disciplines, avoiding the “war of the worlds”’, by D. Tassinari et al. (Ann Oncol 2006; 17: 876)
Authors: G. Bocci, M. Tuccori, U. Emmenegger, V. Liguori, A. Falcone, R.S. Kerbel, M. Del Tacca
Journal: Annals of Oncology (2005)
Medical Ethics in the Renaissance
Authors: John M. Clark
Journal: JAMA (1996)

The continuing evolution of human thinking is best evaluated by comparing our ideas with those of the past and realizing that, even though we have an amazing fund of scientific knowledge, we are still emotional and moral siblings of the ancients. <i>Medical Ethics in the Renaissance</i>is a narrowly focused history of ideas and values. The author spends little time in this 230-page book analyzing the history of the Renaissance but plunges directly into his first topic, the question of physicians lying to patients, one that thrives in our hospital conference rooms today. Do we lie to a patient if it will benefit his health? Do we withhold information? Is deception of colleagues acceptable? Renaissance medical writers varied; some clung to the traditional pronouncements of Hippocrates and Galen, while others debunked their ideas along with the sorcery, mysticism, alchemy, and witchcraft of medicine in the Middle Ages; still others opposed
Jes Olesen: the people's neurologist
Authors: Ruth Williams
Journal: The Lancet Neurology (2010)

Thankfully, many neurological disorders are rare, but migraine affects about 10–30% of people at some point in their lives. This high prevalence is precisely why Jes Olesen, professor of neurology at the University of Copenhagen and chief of the Danish Headache Center at Glostrup University Hospital, Copenhagen, Denmark, chose migraine as his specialty.
On the Pathology and Treatment of Ovarian Diseases
Authors: L. Tait
Journal: BMJ (1874)

THE BRITISr MEDICAL 7OURNAL.* Since writing this essay, I have, however, seen two fibroid tumours of the uterus impacted in the pelvis, and capable of being pushed out of it ; but in both cases the tumours were fundal and the uterus was retroflexed.
The Future Textbook of Medicine
Authors: Paul E. Steiner
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The special review of the new<i>Cecil-Loeb Textbook of Medicine</i>(<b>202</b>:133, 1967) admirably diagnosed the morphology and prognosis of the changes in medical textbooks, but it incompletely diagnosed their etiology. Its emphasis was properly on the new general chapters that introduce each category of diseases. Why have these chapters been added, and what purpose do they serve? They have been added because they are needed. Today's student lacks an adequate understanding of the basic principles which these sections provide. Who has traditionally been responsible for the first systematic exposure, now found deficient, of the student to disease? Chiefly the departments of pathology; they are supposed to lay the groundwork by teaching the principles thereof. If pathology is defined as "the science of disease," then it is the science basic to the clinical subjects. If disease is "any deviation from the normal in form, function, and chemistry
Two-hour 75-g Oral Glucose Tolerance Test Early in Pregnancy Detects Most Cases of Gestational Diabetes
Authors: Umesh Dashora, Vandana Dashora, Lee Kennedy
Journal: Diabetes Care (2002)

We congratulate Schmidt et al. (1) for their excellent work on gestational diabetes mellitus (GDM), published in Diabetes Care . We would like to make several comments. We believe that testing for GDM early in pregnancy would help to detect cases and has the potential to improve pregnancy outcomes. Also, World Health Organization criteria for the diagnosis of GDM received further endorsement at the Fourth International Workshop-Conference on Gestational Diabetes Mellitus in 1977 (2); therefore, 2-h 75-g glucose may be a better diagnostic …
Phase 2 study of VcR-CVAD with maintenance rituximab for untreated mantle cell lymphoma: an Eastern Cooperative Oncology Group study (E1405)
Authors: Julie E. Chang, Hailun Li, Mitchell R. Smith, Randy D. Gascoyne, Elisabeth M. Paietta, David T. Yang, Ranjana H. Advani, Sandra J. Horning, Brad S. Kahl
Journal: Blood (2014)
Primary immunisation and febrile convulsions in Oxford 1972-5.
Authors: P Harker
Journal: BMJ (1977)

A three-year study of febrile convulsions in Oxford with comprehensive notification from general practice and hospitals showed a 3% risk for all children of suffering at least one febrile convulsion by the age of 5 years. Children were most at risk between 6 and 27 months, and febrile convulsions were most likely to be prolonged in children aged 9-15 months. The association between febrile convulsions and primary immunisations in the preceding 28 days was compared in case and control children, matched for age and sex. Results suggested that such association was a chance relationship with age. If association was direct, the febrile convulsion rates per 1000 immunisation doses were estimated as follows: diphtheria, pertussis, tetanus--0-09 per 1000; poliomyelitis--0-6 per 1000; and measles--0-9 per 1000. Hence if any of these vaccines had a secific causal relationship with febrile convulsions, these rates would probably have been much higher.
Even Air in the Home Is Not Entirely Free of Potential Pollutants
Authors: Andrew Skolnick
Journal: JAMA (1989)

A 10-YEAR study by the US Environmental Protection Agency (EPA), Washington, DC, shows that, for some pollutants, the air outside may be safer to breathe than air in the home. Speaking at the American Lung Association's second annual Science Writers' Forum in Annapolis, Md, Lance A. Wallace, PhD, an environmental scientist at the EPA, said that most exposure to a number of known or suspected carcinogens appears to come primarily from personal activities rather than from industrial sources. This is true, he says, even in the country's most concentrated chemical manufacturing areas. <h3>Daily Dangers</h3> The risks Americans may face from some of the pollutants dumped and leaked into the environment by industry may be less than the risks from activities in the home such as smoking, showering, using room deodorizers, and storing and wearing dry-cleaned clothing, Wallace says. Quoting the comic strip "Pogo," he says, "We have met the enemy
Allergy to iprindole (Prondol) with hepatotoxicity.
Authors: P J Young
Journal: BMJ (1970)

thought to be Haemophilus influenzae, or possi- bly a coliform, it grew well on nutrient agar in t-he absence of X and V factors, and did not grow on McConkey's agar.It was finally proved to be Pasteurella multocida, a mouse dying 24 hours after inoculation with a culture of the organism.This organism was sensitive in vitro to penicillin, chloramphenicol, tetracyciine, erythromycin, and cephaloridine.The white blood cell count was only 9,000/cu.mm. on admission, 85 % of these cells being neutrophils.Discharge from the right ear produced a growth of Staphylococcus aureus, but no other organism was identified.The patient was treated initially with full dioses of penicillin, chloramphenicol, and sul- phadimidine.Chloramphenicol was discontinued after one week, and the dose of sulphadimidine was reduced.After a further week the penicillin was replaced by a short oral course of cloxacillin, since the staphylococcus grown from the middle ear was penicillin-resistant.A second C.S.F.specimen obtained 10 days after the first was sterile, but still contained 22 leucocytes (mainly lymphocytes) per cu.mm.Satisfactory progress was maintained, and the patient was discharged home after one month in hospital.No contact with dogs or cats was admitted on direct questioning, and no symptoms of bron- chitis had been noticed.
Cancrum Oris among African Natives
Authors: D. Mackay
Journal: BMJ (1949)

Case 6.-A woman aged 56 was seen on March 4, 1948.She had a history of carcinoma of the cervix treated with radium three years before.For the past year she had had severe intractable cystitis with haematuria at times.When cystoscoped as an out-patient there was so much pus that the bladder wall could not be seen.She was admitted to hospital, and after a week's treatment was cystoscoped again.There was a large ulcer of the bladder base, which appeared malignant.As her general condition was good and she was getting so much trouble from the cystitis I decided to do an exploratory operation and see if there was any chance of a radical removal.At the first- stage operation on May 18, 1948, a dense mass of scar tissue was seen round the cervix, including both ovaries, and adherent to the rectum behind and the bladder base in front.At the second stage, on June 8, cystectomy and hysterectomy were performed.The operation was very difficult; the only pleasant feature was not having to worry about the lower ureters in doing the complete hysterectomy.Repair of the lower peritoneum was a!so difficult after such a wide excision, and was no doubt responsible for the unusual degree of abdominal discomfort and distension which the patient had after the second stage..The pathological report stated: "Cervix: large white mass in cervical wall consists of dense and partially hyalinized fibrous tissue.Both ovaries replaced by a compact mass of dense fibrous tissue.Bladder: the transitional epithelium is somewhat heaped up in places but there is no evidence of invasion.The subepithelial tissue is oedematous and there is a considerable amount of round-celled infiltration of the plasmacell type, the result of chronic irritation."Although no malignant cells were found I think this was at least a precancerous condition.In November, 1948, she was quite well except for attacks of very severe constipation. SummarySix cases with malignant or pre-malignant conditions of the bladder are described.In all the cases transplantation of the ureters was carried out by the method of implanting the ureters irn continuity, as a first stage, followed by cystectomy.There was no operative mortality.
TRANSCATHETER AORTIC VALVE IMPLANTATION IMPROVES LEFT VENTRICULAR MYOCARDIAL MECHANICS IN NORMAL AND ABNORMAL LEFT VENTRICULAR FUNCTION
Authors: Frederic Poulin, Shemy Carasso, Eric Horlick, Mark Osten, Ki-Dong Lim, Heather Finn, Christopher Feindel, Matthias Greutmann, Robert J. Cusimano, Harry Rakowski, Anna Woo
Journal: Journal of the American College of Cardiology (2013)
Abstract LB-189: GRK3 is essential for metastatic cells and promotes prostate cancer progression
Authors: Nanping Ai, Mohit Hulsurkar, Lars Akslen, Randolph Watnick, Ed Harlow, Wenliang Li
Journal: Cancer Research (2014)

Abstract Metastasis is responsible for over 90% of cancer deaths. However, biochemical and molecular mechanisms that regulate tumor progression to metastatic phenotype are still poorly understood, especially the control of survival and proliferation of metastatic cells. Kinases play key roles in regulation of many cellular processes. Here we employed an unbiased RNAi in vitro screen against human kinases and a focused cDNA in vivo screen to identify kinases that have novel roles in metastasis. Beta adrenergic receptor kinase 2 (BARK2, ADRBK2, GRK3) was one of the kinases we discovered to have a novel role in cancer progression through this work. It was essential for survival and proliferation of metastatic cells in vitro and in vivo. Moreover, it was also sufficient to promote primary prostate tumor growth and metastasis upon exogenous expression in poorly metastatic cells in mouse xenograft models. Mechanistically, we found that GRK3 functions at least in part through regulating several angiogenic factors and stimulating angiogenesis. Furthermore, GRK3 was found to be overexpressed in human prostate cancers, especially in metastasis. Taken together, these data suggest that GRK3 plays an important role in prostate cancer progression and metastasis. Citation Format: Nanping Ai, Mohit Hulsurkar, Lars Akslen, Randolph Watnick, Ed Harlow, Wenliang Li. GRK3 is essential for metastatic cells and promotes prostate cancer progression. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-189. doi:10.1158/1538-7445.AM2014-LB-189
Cancer of the Genitourinary Tract
Authors: Wyland F. Leadbetter
Journal: New England Journal of Medicine (1954)

TreatmentThe various therapeutic measures comprise cystoscopic fulguration or resection with the McCarthy resectoscope, transurethral implantation of radioactive materials such as radon seeds, the use of liquid radioactive isotopes within a distensible bag catheter, suprapubic electrodesiccation and resection with or without the implantation of radioactive materials, segmental resection of lesions confined to the distensible portions of the bladder, with or without division and reimplantation of a ureter, unusual operations such as radical prostatectomy combined with excision of the tumor-bearing area at the bladder neck, simple cystectomy, radical cystectomy with lymph-node dissection, pelvic evisceration, deep radiation therapy and combinations. The varied . . .
Patch test dose-response study: polysensitized individuals do not express lower elicitation thresholds than single/double-sensitized individuals
Authors: B.C. Carlsen, L.A. Fischer, H. Sosted, A. Vølund, T. Menné, J.D. Johansen
Journal: British Journal of Dermatology (2008)

It is not known if reduced elicitation thresholds are evident among polysensitized individuals when using allergens to which the patients are already sensitized. Reduced elicitation thresholds may be an expression of increased reactivity in this patient group.To examine and compare elicitation dose-response curves and elicitation thresholds in a polysensitized vs. a single/double-sensitized group for allergens to which the test subjects were already sensitized.Fifty-one patients (13 polysensitized and 38 single/double-sensitized) were patch tested with nickel sulphate, methyldibromo glutaronitrile (MDBGN) and p-phenylenediamine (PPD) in dilution series. The ratio between the doses eliciting a response in 50% of patients in the two groups was used as the measure for relative sensitivity.The dose-response curves of the polysensitized group for MDBGN and PPD were shifted to the right, and for nickel sulphate shifted to the left, compared with the single/double-sensitized group. The relative sensitivity for each of the three allergens and a combined relative sensitivity for all three allergens were not significantly different when comparing the polysensitized and single/double-sensitized groups.No increased sensitivity, in the form of distinct elicitation thresholds, could be demonstrated in polysensitized individuals compared with individuals with one or two contact allergies.
Extent and origin of resistance to antituberculosis drugs in the Netherlands, 1993 to 2011
Authors: C Ruesen, A B van Gageldonk-Lafeber, G de Vries, C G Erkens, J van Rest, H Korthals Altes, H de Neeling, M Kamst, D van Soolingen
Journal: Eurosurveillance (2014)

The elimination of tuberculosis (TB) is threatened by an apparent increase in the level of resistance in Mycobacterium tuberculosis. In the Netherlands, where the majority of TB patients are migrants, resistance may also be increasing. We conducted a retrospective study, using 18,294 M. tuberculosis isolates from TB cases notified between 1993 and 2011. We investigated the trends in antituberculosis drug resistance, focusing on the country of birth of the patients and whether resistance had developed during treatment or was the result of transmission of resistant M. tuberculosis strains. For both scenarios, we determined whether this had happened in or outside the Netherlands. Antituberculosis drug resistance was found in 13% of all cases analysed and showed an increasing trend among patients who had been born in the Netherlands (p<0.001) and a decreasing trend among foreign-born (p=0.02) over the study period. Since 2005, the proportion of M. tuberculosis resistant strains among all strains tested has increased in both groups (p=0.03 and p=0.01, respectively). Overall, we found a significantly increasing trend when excluding streptomycin resistance (p<0.001). The trend was most markedly increased for isoniazid resistance (p = 0.01). Although resistance was mainly due to transmission of resistant strains, mostly outside the Netherlands or before 1993 (when DNA fingerprinting was not systematically performed), in some cases (n=45), resistance was acquired in the Netherlands. We conclude that antituberculosis drug resistance is increasing in the Netherlands, mostly related to migration from high TB-incidence countries, but also to domestic acquisition.
COMPARISON OF BUTYRYLPERAZINE AND TRLFLUOPERAZINE IN CHRONIC SCHIZOPHRENIC SUBJECTS
Authors: WILLIAM MANDEL, PHILIP EVANS
Journal: American Journal of Psychiatry (1962)

Butyrylperazine, a new phenothiazine of the piperazine series, was compared with trifluoperazine in a 3-month study involving 44 chronic schizophrenic patients. The study employed a double-blind, cross over design using a fixed dosage regimen of both drugs. A 2-week placebo interval was used prior to the cross over and at the completion of the study. There were no significant differences in therapeutic effectiveness or incidence of side reactions between the drugs. Similarities between the drugs were greater than differences.
THE EFFECT OF SULFISOXAZOLE*–TRIMETHOPRIM COMBINATION ON TITRATABLE ACIDITY OF HUMAN SEBUM
Authors: JOHN S. STRAUSS, PETER E. POCHI
Journal: British Journal of Dermatology (1970)

Journal Article THE EFFECT OF SULFISOXAZOLE–TRIMETHOPRIM COMBINATION ON TITRATABLE ACIDITY OF HUMAN SEBUM Get access JOHN S. STRAUSS, JOHN S. STRAUSS Department of Dermatology and Evans Memorial Department of Clinical Research, University Hospital, and Department of Dermatology, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts, U.S.A Search for other works by this author on: Oxford Academic Google Scholar PETER E. POCHI PETER E. POCHI Department of Dermatology and Evans Memorial Department of Clinical Research, University Hospital, and Department of Dermatology, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 5, 1 May 1970, Pages 493–496, https://doi.org/10.1111/j.1365-2133.1970.tb02210.x Published: 01 May 1970 Article history Accepted: 20 October 1969 Published: 01 May 1970
Clinical Toxicology of Commercial Products
Authors: Jay M. Arena
Journal: JAMA (1985)

The fifth edition of this classic publication is better and more useful than ever. Its format remains the same, but now the published case reports with the inclusion of clinical experimental research articles expand its role as a reference book and make it doubly effective and valuable. All sections have been enlarged and updated. For example, Section II, "Ingredients Index," has been increased from 273 pages to 460 pages, offering a comprehensive listing and toxicity review of individual product ingredients. This and the "General Formulations" section, which lists in alphabetical order the numerous products and agents commonly found in households and on farms, give ready information and potential ingredient toxicity of the more common products that are involved in accidental and willful poisoning in the United States. Such information is urgently needed in emergencies, when specific product details are required for proper treatment. The latter can be found in Section