How Protozoa Evade Intracellular Killing
Authors: HENRY W. MURRAY
Journal: Annals of Internal Medicine (1983)

Editorials1 June 1983How Protozoa Evade Intracellular KillingHENRY W. MURRAY, M.D.HENRY W. MURRAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-6-1016 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOnce swept inside a polymorphonuclear or mononuclear leukocyte and enclosed within a phagocytic vacuole, ingested microorganisms are immediately confronted with a toxic array of both oxygen-dependent and oxygen-independent microbicidal mechanisms. Phagocytosis not only triggers the generation of lethal oxygen intermediates, including superoxide anion (O-2), hydrogen peroxide (H2O2), and hydroxyl radical, but also stimulates cytoplasmic granules and lysosomes to fuse with the pathogen-containing vacuole and discharge their potentially destructive components. 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MURRAY, M.D.Defects in Host-Defense MechanismsDefects in Host-Defense MechanismsInteraction of Legionella micdadei with human monocytes 1 June 1983Volume 98, Issue 6Page: 1016-1018KeywordsAnionsHomicideLysosomesOxygenPathogensPhagocytesPhagocytosis ePublished: 1 December 2008 Issue Published: 1 June 1983 PDF downloadLoading ...