tbuckley/cabot-search huggingface dataset:
Platelet-associated PF-4 as a biomarker of early tumor growth
Authors: David Cervi, Tai-Tung Yip, Nandita Bhattacharya, Vladimir N. Podust, Jon Peterson, Abdo Abou-Slaybi, George N. Naumov, Elise Bender, Nava Almog, Joseph E. Italiano, Judah Folkman, Giannoula L. Klement
Journal: Blood (2007)
External Validation of Postoperative Nomograms for Prediction of All-Cause Mortality, Cancer-Specific Mortality, and Recurrence in Patients With Urothelial Carcinoma of the Bladder
Authors: Philipp Nuhn, Matthias May, Maxine Sun, Hans-Martin Fritsche, Sabine Brookman-May, Alexander Buchner, Christian Bolenz, Rudolf Moritz, Edwin Herrmann, Maximilian Burger, Derya Tilki, Lutz Trojan, Paul Perrotte, Axel Haferkamp, Markus Hohenfellner, Wolf F. Wieland, Stefan C. Müller, Pierre I. Karakiewicz, Patrick J. Bastian
Journal: European Urology (2011)
SOME INTERRELATIONS OF SOCIAL FACTORS AND CLINICAL DIAGNOSIS IN ATTEMPTED SUICIDE: A STUDY OF 109 PATIENTS
Authors: ELI ROBINS, EDWIN H. SCHMIDT, PATRICIA O'NEAL
Journal: American Journal of Psychiatry (1957)

1. A study has been reported of social factors in the suicide attempts of 109 patients brought to a general hospital immediately after having made a suicide attempt. 2. Patients with chronic alcoholism, conversion reaction, and sociopathic personality reported a much higher frequency of social difficulties, such as marital friction, divorce, job instability, and financial dependency, than did patients with manic-depressive psychosis and chronic brain syndromes. They not only were involved in more social difficulties at the time they made the suicide attempt, but also reported more such difficulties throughout their lives. 3. Just before the manic-depressive and chronic brain syndrome patients attempted suicide they were disturbed by feelings of depression, self-disgust, and worthlessness, but seldom by feelings of anger or spite towards other persons or by feelings of frustration or neglect caused by others, while the patients in the other 3 diagnostic groups showed the opposite pattern. 4. There were probably no psychiatrically well patients and probably no patients with an anxiety reaction (anxiety neurosis) in the entire group of 109 patients who had made a suicide attempt. 5. The interrelationships of social difficulties, diagnosis, and suicide attempt, based on the findings of this study, were discussed.
Treatment of Ciguatera Poisoning with Gabapentin
Authors: Carlos M. Perez, Patricia A. Vasquez, Cecilia F. Perret
Journal: New England Journal of Medicine (2001)

To the Editor: Esteller and colleagues (Nov.9 issue) 1 claim that methylation of the O 6 -methylguanine-DNA methyltransferase ( MGMT ) promoter is associated with improved responsiveness to carmustine and prolonged survival in patients with high-grade gliomas.We believe there are methodologic flaws in the authors' study that call these results into question.First, the patients in the study were treated with a combination of surgery, radiation therapy, and chemotherapy with cisplatin and carmustine.We do not believe the response to carmustine is a discernible end point in this trial, because multiple treatments were administered along with carmustine.Second, although the difference in age between the group of patients with unmethylated tumors and the group with methylated tumors was not statistically different, there was a trend toward an older age in the group with unmethylated tumors.We are not given the distribution of ages above or below 50 years.Since the prognosis worsens with each additional decade of age, such information would be useful in assessing the balance in age between the two groups. 2,3 Third, the median period of survival was approximately 20 months for the patients with unmethylated tumors and approximately 30 months for those with methylated tumors, as compared with an average of about 12 months in other series. 2,3 Moreover, since no deaths occurred before 12 months, it is unlikely that the patients chosen for this study were representative of most patients with the disease.Finally, the small numbers of deaths in the two groups of patients make the results of a statistical comparison questionable.
American Association of Medical Journal Advertisers.
Authors: Geo. E. Pettey
Journal: JAMA (1906)

Memphis, Tenn., March 10, 1906. <h3>To the Editor:</h3> —I am sending herewith for publication inThe Journalcopy of constitution of the American Association of Medical Journal Advertisers. This constitution has been agreed on through correspondence between the medical directors of a number of institutions as the basis of a temporary organization to stand until the annual meeting to be held in connection with the session of the American Medical Association in June. It will come up for confirmation or amendment at that meeting. Owners or superintendents of institutions who are in accord with the objects of this organization, who have not already been reached by direct correspondence, are requested to send their application for membership to the secretary.
Intoxication after an Isopropyl Alcohol Enema
Authors: Jay M. Barnett, Michael Plotnick, Kenneth C. Fine
Journal: Annals of Internal Medicine (1990)

Letters15 October 1990Intoxication after an Isopropyl Alcohol EnemaJay M. Barnett, MD, Michael Plotnick, MD, Kenneth C. Fine, MDJay M. Barnett, MD, Michael Plotnick, MD, Kenneth C. Fine, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-8-638_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Human immunodeficiency virus 1 (HIV-1), responsible for the acquired immunodeficiency syndrome (AIDS), has multiple mechanisms of transmission; these include high-risk sexual practices such as anal receptive intercourse. Despite efforts to promote risk reduction, there is some indication that this type of activity continues in at-risk groups. Many disinfectants, including 70% isopropyl alcohol, rapidly and effectively inactivate the HIV virus. Although toxicity resulting from oral, respiratory, and cutaneous absorption of isopropyl alcohol are well described, rectal administration of isopropyl alcohol has only been reported once, in the setting of a suicide attempt (1). We report a case of...Reference1. CorbettMeier JG. Suicide attempted by rectal administration of drug. JAMA. 1968;206:2320-1. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIsopropyl AlcoholIsopropyl AlcoholIsopropanol poisoningAccidental Isopropyl Alcohol Enema Leading to Coma and DeathIsopropyl alcohol 15 October 1990Volume 113, Issue 8Page: 638-639KeywordsAIDSAlcoholismAlcoholsHIVHIV-1IntoxicationSuicideToxicity Issue Published: 15 October 1990 PDF DownloadLoading ...
Tainted Truth: The Manipulation of Fact in America
Authors: Ronald E. Gots
Journal: JAMA (1995)

<i>Tainted Truth</i>is a well-researched, if confusing, exposé of science-for-hire. No bodies of data escape the author's probing. Opinion polls, advertising statistics, studies designed to promote legislation, data for the courtroom, and biomedical research deserve equal skepticism when they are bought and paid for by self-interested parties. The intensity of Crossen's research and her style bespeak her background as a writer and editor for the<i>Wall Street Journal</i>. The reader is propelled from one situation to another in a manner more appropriate to journalistic reporting than to a research treatise. Crossen demonstrates certain inconsistencies, which detract from her message. An exploration of the oat bran cholesterol-lowering controversy concludes that Quaker Oats bought the results. She criticizes the Quaker-sponsored meta-analysis that was used to add power to the supportive studies. However, in the case of passive smoking, she praises the Environmental Protection Agency's estimates of lung cancer, failing to note that
Aldosterone and cardiac fibrosis: in vitro studies
Authors: M. J Fullerton, J. W Funder
Journal: Cardiovascular Research (1994)

Increased cardiac collagen is seen in uninephrectomised rats made hypertensive by aldosterone infusion and high salt, with the possibility of a direct effect of aldosterone at the level of the cardiac fibroblast. The aim of this study was to examine the effects of aldosterone, glucocorticoids, and angiotensin II on collagen production in a series of rat cardiac fibroblast cultures.Cardiac fibroblast cultures were established from neonatal and adult rats of Sprague-Dawley, WKY, and SHR strains, with collagen synthesis measured by incorporation of [3H]proline into collagen. Cells were grown alone or co-cultured with cardiomyocytes, and exposed to aldosterone, glucocorticoids, or angiotensin II for 24-28 h before determination of [3H]proline incorporation.Aldosterone did not affect production of collagen; in contrast, angiotensin II increased, and the glucocorticoid agonist RU28362 suppressed, collagen production in cultured cardiac fibroblasts in the various rat strains.Aldosterone does not exert a direct effect on collagen synthesis in rat cardiac fibroblasts grown in culture. The increased cardiac collagen observed in vivo in aldosterone treated, salt loaded rats may thus represent secondary effects of aldosterone in this model.
Exploring the Benefits of Group Psychotherapy in Reducing Alexithymia in Coronary Heart Disease Patients: A Preliminary Study
Authors: Margarita Beresnevaite
Journal: Psychotherapy and Psychosomatics (2000)

&lt;i&gt;Background:&lt;/i&gt; Although there is preliminary evidence that alexithymia may influence the course of coronary heart disease (CHD), there are no studies exploring attempts to modify alexithymic characteristics in cardiac patients. &lt;i&gt;Method:&lt;/i&gt; Twenty post-myocardial infarction (MI) patients (19 men and 1 woman) were placed in a treatment group, which received weekly group psychotherapy for 4 months. Seventeen post-MI patients (16 men and 1 woman) were placed in a comparison group which received two educational sessions over a period of 1 month. All subjects completed the Toronto Alexithymia Scale (TAS) before the start of group therapy, at the end of the 4-month period, and in follow-up assessment after 6-month, 1-year, and 2-year intervals. &lt;i&gt;Results:&lt;/i&gt; In the psychotherapy treatment group, there was a significant reduction in the mean TAS score following group therapy, which was maintained over the 2-year follow-up period. In the educational group, there were no significant changes in mean TAS scores between the initial testing and any of the follow-up intervals. On an individual basis, a decrease to a lower level of TAS scores occurred in a higher percentage of patients in the treatment group than in the educational group. Over the 2-year follow-up period, patients with decreased alexithymia following group therapy experienced fewer cardiac events (reinfarction, sudden cardiac death, or rehospitalization for rhythm disorder or severe angina) than patients whose alexithymia remained unchanged. &lt;i&gt;Conclusions:&lt;/i&gt; The results indicate that group psychotherapy is able to decrease alexithymia and that for many patients this change can be maintained for at least 2 years. A reduction in the degree of alexithymia seems to influence favorably the clinical course of CHD.
Drug Costs and Drug Quality
Authors: LOUIS LASAGNA
Journal: Annals of Internal Medicine (1974)

Editorials1 August 1974Drug Costs and Drug QualityLOUIS LASAGNA, M.D.LOUIS LASAGNA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-2-261 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptControversy about the relative merits of brand-name and generic prescription is nothing new. For years advocates of generic prescription have argued that generic drugs are cheaper than brand-name forms of the same drugs, whereas most physicians have aligned themselves with the pharmaceutical industry in the belief that brand-name drugs are more reliable than the generic drugs and that saving money at the cost of quality is a bad bargain.What is different about recent discussions, however, is the availability of data on both cost and quality, rather than simply the ex cathedra expositions of earlier times. Enough studies have now... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Pharmacology and Toxicology University of Rochester School of Medicine and Dentistry Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBioavailability and genetic prescribing 1 August 1974Volume 81, Issue 2Page: 261-262KeywordsDrugs Issue Published: 1 August 1974 PDF DownloadLoading ...
Intraperitoneal Radioactive Phosphorus (<sup>32</sup>P) Versus Observation After Negative Second-Look Laparotomy for Stage III Ovarian Carcinoma: A Randomized Trial of the Gynecologic Oncology Group
Authors: Mahesh A. Varia, Frederick B. Stehman, Brian N. Bundy, Jo Ann Benda, Daniel L. Clarke-Pearson, Ronald D. Alvarez, Harry J. Long
Journal: Journal of Clinical Oncology (2003)

The objectives of this prospective randomized study of consolidation therapy were to evaluate recurrence-free survival (RFS), overall survival (OS), and the morbidity of intraperitoneal (IP) chromic phosphate suspension (32P) therapy in patients with stage III epithelial ovarian carcinoma who have no detectable evidence of disease at the second-look laparotomy (SLL) procedure after primary chemotherapy.In a multi-institution clinical cooperative trial, 202 eligible patients with a negative SLL were randomly selected to receive either 15 mCi IP 32P (n = 104) or no further therapy (NFT; n = 98).With a median follow-up of 63 months in living patients, 68 patients in the IP 32P group (65%) and 63 patients in the NFT group (64%) have developed tumor recurrence. The relative risk of recurrence is 0.90 (IP 32P to NFT) (90% confidence interval [CI], 0.68 to 1.19). The 5-year RFS rate is 42% and 36% for the IP 32P and NFT groups, respectively; the difference is not statistically significant (log-rank test, P =.27). There was no statistically significant difference in OS (P =.19). The relative risk of death is 0.85 (IP 32P to NFT) (90% CI, 0.62 to 1.16). Sixteen patients (8%) experienced grade 3 or 4 adverse effects, with eight in each respective group.Intraperitoneal chromic phosphate did not decrease the risk of relapse or improve survival for patients with stage III epithelial ovarian cancer after a negative SLL. Despite complete pathologic remission at SLL after initial surgery and platinum-based chemotherapy, 61% of stage III ovarian cancer patients had tumor recurrence within 5 years of negative SLL. This indicates a need for more effective initial therapy and further studies of consolidation therapy.
Acute Myeloid Leukemia With Myeloid Sarcoma and Eosinophilia: Prolonged Remission and Molecular Response to Imatinib
Authors: Dana Védy, Dominique Muehlematter, Thierry Rausch, Michèle Stalder, Martine Jotterand, Olivier Spertini
Journal: Journal of Clinical Oncology (2009)

Prolonged Remission and Molecular Response to ImatinibIn October 2004, a 63-year-old patient was referred to our medical center for investigation of bone pains, headache, and weight loss.On admission, peripheral blood WBC count was 7.2 ϫ 10 9 /L, hemoglobin 12.4 g/dL, and platelets 126 ϫ 10 9 /L.The differential count showed 45% neutrophils, 27% eosinophils, 14% lymphocytes, 1% monocytes, 2% basophils, 9% myeloid precursors, 2% blasts, and one erythroblast/100 WBCs.Computed tomography showed a paravertebral mass at D4-D5 level (44 ϫ 37 mm; Fig 1A).Magnetic resonance imaging disclosed a sphenoidal mass with intraorbital and medial fossa extension (Fig 1B) and a mass infiltrating L3 vertebra with extradural infiltration and dural compression.Osteolytic lesions were observed in all lumbar vertebras and in several dorsal and cervical A C B
Belfast children's heart surgery unit should close, says health board
Authors: C. Dyer
Journal: BMJ (2013)

Children born with congenital heart defects in Northern Ireland should have their surgery carried out in future in Dublin rather than Belfast, a report from the province’s Health and Social Care Board has recommended.

Northern Ireland’s health minister, Edwin Poots, is expected to make a final decision within a few weeks, but his approval is thought to be a formality.

Campaigners have battled to keep the surgery in Northern Ireland, and more than 80 members of the legislative assembly …
Removal of Foreign Bodies from Subsegmental Bronchi with the Fiberbronchoscope
Authors: E. Papamichael
Journal: Endoscopy (1976)

Though the fiberbronchoscope has been designed for diagnostic purposes, it can be used, as well, for the removal of small foreign bodies from segmental and subsegmental bronchi; In this paper we report two cases in which we successfully removed from subsegmental bronchi a pulp-canal reamer and a melon seed. This fact proves that in some of these cases we can avoid thoracotomies.
Psoriasiform and sclerodermoid dermatitis of the fingers with apparent shortening of the nail plate: a distinct entity?
Authors: R. CAPUTO, C. GELMETTI, R. GRIMALT, R. GIANOTTI
Journal: British Journal of Dermatology (1996)

A Caucasian boy, born to unrelated parents, and with no family history of psoriasis or atopy, developed chronic psoriasiform dermatitis on the palmar surface of the fingers when he was a year old. At the age of 6, the dorsal surface acquired a sclerodermoid appearance and the nail plates appeared to be shortened. The disease was unsuccessfully treated topically with emollients, keratolytic agents and corticosteroids. At the age of 9, when he was hospitalized, finger motility was limited and painful, and movements of the hands were impaired. The feet were normal. All the investigations were within normal limits. Histology of a biopsy revealed parakeratosis, acanthosis with papillomatosis, exocytosis and spongiosis. He was treated with a new oral non-steroidal anti-inflammatory drug, nimesulide (100 mg/day for 20 days, and then 50 mg/day for 20 days), and emollients. Marked improvement, and restoration of finger motility, were achieved after the first month of treatment; the nail plates reappeared because of regression of the eponychium.
Primary Ovarian Pregnancy
Authors: James A. Zimble
Journal: JAMA (1970)

Primary ovarian pregnancy is an extremely unusual form of ectopic gestation, occurring in 1:25,000 to 1:40,000 pregnancies. Most cases are diagnosed and treated in the first trimester, and have a history and findings similar to those of tubal ectopic pregnancies or ruptured corpus luteum cysts. Although preexisting infection and pelvic endometriosis have been cited as possible predisposing factors, the etiology remains obscure. Excision of the affected ovary and tube is the present accepted therapy.
777 HEPATOCELLULAR ADENOMAS (HCA) IN MEN ARE MAINLY SOLITARY AND OF INFLAMMATORY PHENOTYPE
Authors: P. Bioulac-Sage, S. Rebuissou, H. Laumonier, A. Rullier, G. Cubel, G. Cauchy, A. Sa Cunha, J. Saric, J. Zucman-Rossi, C. Balabaud
Journal: Journal of Hepatology (2009)
Naproxen in rheumatoid arthritis. Extended trial.
Authors: A G Mowat, B M Ansell, J M Gumpel, H F Hill, A G Hill, M Stoppard
Journal: Annals of the Rheumatic Diseases (1976)

121 patients with active rheumatoid arthritis, 91 of whom had proved intolerant of other nonsteroidal anti-inflammatory agents, were treated for a mean of 10 months with naproxen. A dosage of 250 mg twice daily produced sustained improvement in most of the standard clinical measurements. 28 patients complained of side effects, with a lower than expected incidence of gastrointestinal complaints and no drug-induced rash being recorded. 19 patients withdrew from the trial because of side effects, while a further 22 withdrew because the drug was ineffective. Naproxen is a useful drug for long-term use in patients with rheumatoid arthritis, including those who have proved intolerant of or experienced inadequate symptomatic relief from other nonsteriodal anti-inflammatory agents.
The prognostic value of submaximal exercise testing with radionuclide ventriculography before hospital discharge in patients with recent myocardial infarction.
Authors: J R Corbett, G J Dehmer, S E Lewis, W Woodward, E Henderson, R W Parkey, C G Blomqvist, J T Willerson
Journal: Circulation (1981)

To test the hypothesis that patients at risk of future cardiac events can be identified by sub-maximal exercise testing with radionuclide ventriculography (RVG), 61 patients were studied a mean of 19 +/- 1.0 days (+/- SEM) after acute myocardial infarction (MI). RVGs were used to measure left ventricular ejection fraction (LVEF), wall motion score (WMS), end-diastolic volume (EDV) and end-systolic volume (ESV), and the ratio of systolic blood pressure to ESV (P/V index) at rest and during submaximal exercise. Frank lead ECGs were analyzed for ST-segment change and arrhythmias. These patients were followed for a mean of 9.6 months (60 for 6 months or more and one for 3 months) to determine the incidence of cardiac death, recurrent MI, unstable or medically refractory angina, persistent congestive heart failure (CHF) or limiting angina; these problems were considered to be important cardiac events. At the 6-month follow-up, 37 patients had important complications: four patients died, five had MI, seven had unstable or medically refractory angina, 11 had persistent CHF and 10 had severe limiting angina. The sensitivity and specificity of RVG in predicting the important postinfarct complications listed above were 95% and 96% for failure to increase LVEF by at least 5 units, 95% and 96% for an increase in ESV of more than 5%, 97% and 88% for failure of the P/V index to increase by more than 35%, and 81% and 88%, respectively, for a decrease in WMS. The sensitivity and specificity of the ECG in predicting important complications were 54% and 58%, respectively. The rest and submaximal exercise RVG variables, the ECG, a history of MI, the location of the infarction, Killip class III, age, sex, and maximal work load performed were analyzed statistically to determine the best predictors of prognosis. The change with exercise in LVEF, ESV and the P/V index were most significant variables in predicting prognosis during the 6-month follow-up period. When patients with subsequent cardiac events were separated into those with death, recurrent MI and unstable or medically refractory angina as major cardiac events, and patients with persistent CHF and limiting angina as less important ("minor") cardiac events, only the peak submaximal exercise LVEF and history of MI were significant in distinguishing these groups. In patients without important cardiac events during the 3- and 6-month follow-up, 70% and 88%, respectively, no abnormality in the responses of LVEF, ESV, or P/V index to submaximal exercise. These results suggest that submaximal exercise testing with RVG is a highly sensitive means of classifying patients at the time of hospital discharge after MI according to the likelihood of having cardiac events during the ensuing 6 months.