tbuckley/cabot-search huggingface dataset:
Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis
Authors: Deborah Krakow, Stephen P Robertson, Lily M King, Timothy Morgan, Eiman T Sebald, Cristina Bertolotto, Sebastian Wachsmann-Hogiu, Dora Acuna, Sandor S Shapiro, Toshiro Takafuta, Salim Aftimos, Chong Ae Kim, Helen Firth, Carlos E Steiner, Valerie Cormier-Daire, Andrea Superti-Furga, Luisa Bonafe, John M Graham, Arthur Grix, Carlos A Bacino, Judith Allanson, Martin G Bialer, Ralph S Lachman, David L Rimoin, Daniel H Cohn
Journal: Nature Genetics (2004)
LYMPHOSCINTIGRAPHY WITH IN-111 LABELED MONOCLONAL ANTIBODIES
Authors: David A. Goodwin, Claude F. Meares, Michael J. McCall, Hugh O. McDevitt, Maureen McTigue, Carol I. Diamanti
Journal: Clinical Nuclear Medicine (1983)

Goodwin, David A.; Meares, Claude F.; McCall, Michael J.; McDevitt, Hugh O.; McTigue, Maureen; Diamanti, Carol I. Author Information
Investigations on the Source of Diastase in Serum and Urine.
Authors: Martin M. Nothman
Journal: Annals of Internal Medicine (1965)

s1 November 1965Investigations on the Source of Diastase in Serum and Urine.Martin M. Nothman, M.D., Allan D. Callow, M.D.Martin M. Nothman, M.D.Search for more papers by this author, Allan D. Callow, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-910_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptValues for serum and urinary diastase do not change after subtotal pancreatectomy in man and after complete extirpation of the gland in dogs. When the pancreatic ducts are ligated these enzymes become markedly increased. They rise further when secretin is injected. They fall to their original values when the pancreas is removed after duct ligation. The same effect is obtained by establishment of a pancreatic fistula after ligation: both diastases return to their original levels. Secretin given after performance of the fistula does not affect the values for diastase in serum or urine. But the amount of diastase secreted through... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 910-910KeywordsEnzymesFallsFistulasLigation assayPancreasPancreatectomyPancreatic ductsSecretinUrine Issue Published: 1 November 1965 PDF DownloadLoading ...
Alcohol Abuse Disorders
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevention of atherosclerotic complications with ketanserin
Authors: I. Dews, C. E Marks, M. Vandenburg, J. Stephens
Journal: BMJ (1989)

The National Audit Office came to this unit for the data and despite being given graphs and bar charts requested the raw data as well.The published graph of male trends in mortality was prepared here.The bar chart of comparative mortality, however, which was reproduced in the BMJ and by the national media, originated within the National Audit Office.It makes out Sweden to have the highest coronary heart disease mortality of the developed economies.Unfortunately, my exhortation not to use crude all ages rates cannot have been passed on to whoever prepared the graph, which was not checked with me.
ONE OF THE CAUSES OF IMPERFECTION IN THE RADIOGRAPHIC IMAGE.
Authors: HENRY POWER
Journal: JAMA (1905)

Two recent articles on the x-ray inThe Journalof the American Medical Association have interested me much. One in particular, in which the author, Dr. Stover of Denver, touches on the subject of the formation of<i>x</i>-rays at parts of the Crookes tube remote from the target. The belief in the formation of such rays is widespread and, no doubt, has some origin in fact. I wish in this paper to show that in some cases at least these rays are not thus produced, and can not, therefore, be held responsible for the bad effects noticed in radiography which are usually laid at their door. That there is, nevertheless, some obscure cause at work which tends to reduce the sharpness of the radiograph or of the fluoroscopic image is undoubted and it may be stated further that the<i>x</i>-rays do reach the photographic plate from directions other
The Adoption (in Celebration of Arielle)
Authors: Bruce A. Ourieff
Journal: Annals of Internal Medicine (1997)

Ad Libitum1 July 1997The Adoption (in Celebration of Arielle)Bruce A. Ourieff, MDBruce A. Ourieff, MDSanta Maria, CA 93454.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-1-199707010-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Her arrival came suddenly, a long distant call.Her lineage unclear, her existence undeniable.Could she be ours, was that possible?Truly, she belongs to no other.Creation, an artful assemblageblind, if not indifferent to the artist.In the tapestry of mankind, who creates the thread?Truly, she belongs to no other.The house is in chaos as we prepare.What to tell the girlchild of our own blood?What indeed, her young eyes see love and anticipation.Truly, she belongs to no other.There is a birth, mother coaches mother.A child is borne and passed from one to the other amid promises and tears.An infant enters the family of ... Author, Article, and Disclosure InformationAffiliations: Santa Maria, CA 93454.Corresponding Author: Bruce A. Ourieff, MD, 821 East Chapel, Suite 201, Santa Maria, CA 93454.Corresponding Author: Bruce A. Ourieff, MD, 821 East Chapel, Suite 201, Santa Maria, CA 93454. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1997Volume 127, Issue 1Page: 12KeywordsBirthBloodInfants Issue Published: 1 July 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Deep cutting injury from the edges of a snowboard
Authors: T Matsunaga, S Saitoh, H Tanikawa, M Hayashi, M Ohira, T Kimura
Journal: British Journal of Sports Medicine (2004)

A laceration deep enough to reach the bone occurs very rarely in skiing or snowboarding. Two such cases are presented here. In one case, the popliteal fossa of a skier was cut during a collision with a snowboarder. All structures posterior to the knee were severed and the leg became ischaemic. The other case was of a snowboarder who sustained a deep cut to the distal forearm during landing after a jump, resulting in a "spaghetti wrist".
The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span
Authors: Ji-Wu Wang, Jonathan R. Brent, Andrew Tomlinson, Neil A. Shneider, Brian D. McCabe
Journal: Journal of Clinical Investigation (2011)

The fatal adult motor neuron disease amyotrophic lateral sclerosis (ALS) shares some clinical and pathological overlap with frontotemporal dementia (FTD), an early-onset neurodegenerative disorder. The RNA/DNA-binding proteins fused in sarcoma (FUS; also known as TLS) and TAR DNA binding protein-43 (TDP-43) have recently been shown to be genetically and pathologically associated with familial forms of ALS and FTD. It is currently unknown whether perturbation of these proteins results in disease through mechanisms that are independent of normal protein function or via the pathophysiological disruption of molecular processes in which they are both critical. Here, we report that Drosophila mutants in which the homolog of FUS is disrupted exhibit decreased adult viability, diminished locomotor speed, and reduced life span compared with controls. These phenotypes were fully rescued by wild-type human FUS, but not ALS-associated mutant FUS proteins. A mutant of the Drosophila homolog of TDP-43 had similar, but more severe, deficits. Through cross-rescue analysis, we demonstrated that FUS acted together with and downstream of TDP-43 in a common genetic pathway in neurons. Furthermore, we found that these proteins associated with each other in an RNA-dependent complex. Our results establish that FUS and TDP-43 function together in vivo and suggest that molecular pathways requiring the combined activities of both of these proteins may be disrupted in ALS and FTD.
High-frequency ultrasound-guided disruption of glycoprotein VI-targeted microbubbles targets atheroprogressison in mice
Authors: Katja Metzger, Sebastian Vogel, Madhumita Chatterjee, Oliver Borst, Peter Seizer, Tanja Schönberger, Tobias Geisler, Florian Lang, Harald Langer, Johannes Rheinlaender, Tilman E. Schäffer, Meinrad Gawaz
Journal: Biomaterials (2014)
Responding to Measles in the Postelimination Era
Authors: Julia Shaklee Sammons
Journal: Annals of Internal Medicine (2014)

Letters2 December 2014Responding to Measles in the Postelimination EraJulia Shaklee Sammons, MD, MSCEJulia Shaklee Sammons, MD, MSCEFrom Perelman School of Medicine, University of Pennsylvania, and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5030-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I appreciate Dr. Duchin's expansion on some of the nuances in measles recognition. It is true that clinical presentations may vary in those who have been previously vaccinated. Immunocompromised patients may also present with a modified clinical picture. In addition, I agree that the absence of Koplik spots should not exclude measles from the differential diagnosis of a patient who has other relevant clinical features and an appropriate exposure history, particularly because these spots are transient, lasting between 2 and 3 days. Still, for providers who have never seen measles, the critical first step is awareness and the ...References1. Advisory Committee on Immunization Practices. Immunization of health-care personnel: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011;60:1-45. [PMID: 22108587] MedlineGoogle Scholar2. Siegel JD, Rhinehart E, Jackson M, Chiarello L; Health Care Infection Control Practices Advisory Committee. 2007 guideline for isolation precautions: preventing transmission of infectious agents in health care settings. Am J Infect Control. 2007;35:S65-164. [PMID: 18068815] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Perelman School of Medicine, University of Pennsylvania, and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-0892. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReady or Not: Responding to Measles in the Postelimination Era Julia Shaklee Sammons Ready or Not: Responding to Measles in the Postelimination Era Julia Shaklee Sammons Responding to Measles in the Postelimination Era Jeffrey S. Duchin Responding to Measles in the Postelimination Era Jeffrey S. Duchin Metrics Cited byMeasles VirusMeasles Virus Fusion Protein: Structure, Function and InhibitionA Structurally Unresolved Head Segment of Defined Length Favors Proper Measles Virus Hemagglutinin Tetramerization and Efficient Membrane Fusion Triggering 2 December 2014Volume 161, Issue 11Page: 842KeywordsConflicts of interestDisclosureMeaslesRashesVentilators ePublished: 2 December 2014 Issue Published: 2 December 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Indoleamine 2,3-dioxygenase–expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas
Authors: Dagmar von Bubnoff, Marina Scheler, Helene Wilms, Jörg Wenzel, Nikolas von Bubnoff, Georg Häcker, Joachim Schultze, Alexey Popov, Paul Racz, Thomas Bieber, Claudia Wickenhauser
Journal: Journal of the American Academy of Dermatology (2011)
1015. Assessment of Zinc Finger-FOKI Chimeric Endonuclease Activity Using a Single Strand Annealing Assay in Mammalian Cells
Authors: Vincent Brondani, DavidJ. Segal
Journal: Molecular Therapy (2006)

Correction of the genetic mutations that underlie genetic diseases remains an essential goal of gene therapy. Repair by homologous recombination (HR) is a promising therapeutic strategy. In mammalian cells, HR is a rare event that can be stimulated by creating a double strand break (DSB) near the site to be modified. A DSB at specific genomic location can be accomplished using customized zinc finger proteins fused to a FokI endonuclease catalytic domain (ZFP-FOKI). To target non-palindromic sequences, two ZFPs engineered for distinct sequences are needed.
Failure to demonstrate the true resection margins of excised skin tumours: a case for routine marking
Authors: D.A. PATERSON, J.D. DAVIES, K.M. McLAREN
Journal: British Journal of Dermatology (1992)

A solution of silver nitrate in methanol was used to assess the demonstration of the true surgical excision margin at histology of 100 skin excisions for basal cell carcinoma. In 15% of cases the true margin was not presented and deeper sections were required. The findings highlight the need for routine marking of excision specimens of neoplastic skin lesions to prevent incorrect diagnosis of incomplete excision based on a false resection margin.
FUNCTIONAL BRAIN DEGENERACY.Read in the Section on Medical Jurisprudence and Neurology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.
Authors: J. T. SEARCY
Journal: JAMA (1891)

It is interesting to notice how much we are given to the habit of grading and estimating others in society. We are continually engaged in this kind of work, and we consider the opinions we have of our acquaintances and associates as very valuable items of information. So intuitive and instinctive is this kind of work that we do it unconsciously, as it were; and as soon as we make an acquaintance, we find ourselves silently estimating and classifying him. The two particulars in which we generally consider it very important to estimate others are, first, their intellectual ability; and secondly, their ethical sense. We call these "mental and moral qualities," and recognize that they are more or less distinct and separate. In common with all other living beings, man lives in competitive life; and so fundamental and continuous, from the earliest existence of life in the world, has been
Itching — Research Has Barely Scratched the Surface
Authors: Malcolm W. Greaves
Journal: New England Journal of Medicine (1992)

ITCHING is the dominant symptom of skin disease and a frequent manifestation of systemic disease. It causes more distress than even pain, because it is frequently intractable. Numerous analgesic drugs relieve pain effectively, but there are no specific antipruritic drugs. Research on the pathophysiologic features of itching has been meager. Because itching has traditionally been considered a response to a stimulus below the threshold of pain, many investigators have assumed that research models for pain are applicable and have therefore neglected itching as a separate sensation.Although pain and itching are both transmitted through the C fibers of polymodal nociceptors, . . .
Successful Liver Transplantation from a Living Donor to Her Son
Authors: Russell W. Strong, Stephen V. Lynch, Tat Hin Ong, Hidetoshi Matsunami, Yuichi Koido, Glenda A. Balderson
Journal: New England Journal of Medicine (1990)

ORTHOTOPIC liver transplantation is an effective therapy for end-stage liver disease and has proved to be a major advance in the treatment of liver disease in children.1 The foremost obstacle faced by transplantation units worldwide has been the relative paucity of infant and child donors. The principle of transplanting a portion of the liver from an adult into a child has been accepted in many centers.2 3 4 In March 1987, an orthotopic reduced-size liver transplantation was performed in Brisbane, Australia. This was our first experience with the technique, which involved the retention of the recipient's inferior vena cava, to which the . . .
An endovascular approach to stroke prevention in atrial fibrillation: Results of the multicenter PLAATO (Percutaneous left atrial appendage transcatheter occlusion) feasibility trial
Authors: Mark Reisman, William Gray, Horst Sievert, Paul Kramer, Peter C. Block, Carlo DiMario, Antonio L. Bartorelli, Paolo Della Bella, Heyder Omran, Athena Poppas, David O. Williams, Allan Skanes, Bernhard Meier, Toshiko Nakai, Michael D. Lesh
Journal: Journal of the American College of Cardiology (2003)
Worldwide Antipolio Campaign Strategy Evolving
Authors: Phil Gunby
Journal: JAMA (1992)

POLIOMYELITIS eradication officials are looking forward to April, which—if no belated reports come along to spoil things—would be the anniversary of the last confirmed case of polio in Latin America in 1991. Now, officials of the World Health Organization, United Nations Children's Fund, and the private sector—particularly the 25 500-club Rotary International organization—are focusing also on Cambodia, China, Laos, Papua New Guinea, the Philippines, and Vietnam. <h3>Year 2000 Eradication Goal</h3> The World Health Organization hopes to eradicate polio worldwide by the year 2000 (<i>JAMA</i>. 1992;267:15-23). One of those working toward this goal, Edward F. Rossomando, PhD, University of Connecticut Health Center, Farmington, is reporting this month on a system to monitor sewage for presence of the polio virus. The biochemist has been testing the system in Mexico with support from the Pan American Health Organization, a regional division of the World Health Organization. <h3>Not Just Poliomyelitis</h3> In addition to polio,
Dialysis and Psoriasis
Authors: KARL D. NOLPH
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 August 1978Dialysis and PsoriasisKARL D. NOLPH, M.D., JACK RUBIN, M.D., PHILIP C. ANDERSON, M.D.KARL D. NOLPH, M.D.Search for more papers by this author, JACK RUBIN, M.D.Search for more papers by this author, PHILIP C. ANDERSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-2-285_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We are encouraged by the many letters in the June issue (Ann Intern Med 88:842-843, 1978) reporting additional experiences wherein psoriasis improved with dialysis. Dr. Wilson's letter in that issue, however, is incorrect with regard to our protocol for dialysis of patients with psoriasis. The protocol, as published, did explain our use of heparin; specifically, "Heparin (1000 U/2 litres) was added to the initial four exchanges."Dr. Wilson's letter describes his experience with intermittent heparin injections and dramatic clearing of psoriasis in two patients. The patients apparently were receiving heparin injections for their coronary arterial disease. As... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Missouri Medical Center Columbia, MO 65212 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDialysis and Haemofiltration for Non-Renal ConditionsDialysis for PsoriasisDialysis and PsoriasisALLEN R. NISSENSON, M.D., MARVIN J. RAPAPORT, M.D., ROBERT G. NARINS, M.D.Hemodialysis in the Treatment of Psoriasis A Controlled TrialALLEN R. NISSENSON, M.D., MARVIN RAPAPORT, M.D., ARTHUR GORDON, M.D., ROBERT G. NARINS, M.D. 1 August 1978Volume 89, Issue 2Page: 285-285KeywordsHeparinMedical dialysisPsoriasisStable coronary artery disease Issue Published: 1 August 1978 PDF downloadLoading ...
Transmission of Manic-Depressive Illness
Authors: Julien Mendlewicz
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In response to our paper entitled "Evidence for X-Linkage in the Transmission of Manic-Depressive Illness" (222:1624, 1972), Green et al (233:1289, 1973) cited the existence of father-to-son transmission in 11% of the families they studied, a phenomenon inconsistent with X-linked inheritance. Their finding, however, is not incompatible with our conclusion that, at least in some families, a dominant X-linked gene is involved in the pathogenesis of manic-depressive illness. In fact, 8% of the families we have studied exhibit father-son transmission after ruling out assortative mating. The findings of X-linkage in some families, and the existence of other families in which X-linkage can be ruled out, suggest (as indicated in our paper) that manic-depressive illness is a genetically heterogeneous condition.<sup>1,2</sup>
Subversion of Protein Kinase Cα Signaling in Hematopoietic Progenitor Cells Results in the Generation of a B-Cell Chronic Lymphocytic Leukemia–Like Population <i>In vivo</i>
Authors: Rinako Nakagawa, Jae Won Soh, Alison M. Michie
Journal: Cancer Research (2006)

Abstract B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of long-lived mature B cells with the distinctive phenotype CD19hi CD5+ CD23+ IgMlo, which are refractory to apoptosis. An increased level of apoptosis has been observed on treatment of human B-CLL cells with protein kinase C (PKC) inhibitors, suggesting that this family of protein kinases mediate survival signals within B-CLL cells. Therefore, to investigate the ability of individual PKC isoforms to transform developing B cells, we stably expressed plasmids encoding PKC mutants in fetal liver–derived hematopoietic progenitor cells (HPC) from wild-type mice and then cultured them in B-cell generation systems in vitro and in vivo. Surprisingly, we noted that expression of a plasmid-encoding dominant-negative PKCα (PKCα-KR) in HPCs and subsequent culture both in vitro and in vivo resulted in the generation of a population of cells that displayed an enhanced proliferative capacity over untransfected cells and phenotypically resemble human B-CLL cells. In the absence of growth factors and stroma, these B-CLL-like cells undergo cell cycle arrest and, consistent with their ability to escape growth factor withdrawal-induced apoptosis, exhibited elevated levels of Bcl-2 expression. These studies therefore identify a unique oncogenic trigger for the development of a B-CLL-like disease resulting from the subversion of PKCα signaling. Our findings uncover novel avenues not only for the study of the induction of leukemic B cells but also for the development of therapeutic drugs to combat PKCα-regulated transformation events. (Cancer Res 2006; 66(1): 527-34)