tbuckley/cabot-search huggingface dataset:
Intratumoral Injection of Dendritic Cells Transduced by an SV40-Based Vector Expressing Interleukin-15 Induces Curative Immunity Mediated by CD8+ T Lymphocytes and NK Cells
Authors: Maria Vera, Nerea Razquin, Jesús Prieto, Ignacio Melero, Puri Fortes, Gloria González-Aseguinolaza
Journal: Molecular Therapy (2005)

Cancer immunotherapy has been extensively attempted by gene transfer of cytokines with viral vectors. In this work, we compared the therapeutic effects of interleukin 12 and 15 (IL-12 and IL-15) genes transferred to tumor cells or to dendritic cells (DCs), which were subsequently injected into established tumors. For this purpose, we used viral vectors based on simian virus 40 (rSV40). Importantly, we observed that nonmatured DCs infected with rSV40 vectors remained phenotypically immature. Infection of CT-26 tumor cells with rSV40 expressing IL-12 (rSVIL-12) or IL-15 (rSVIL-15) failed to inhibit tumor development. In contrast, the intratumoral administration of syngeneic DCs transduced with rSVIL-12 or rSVIL-15 was associated with a strong antitumor response; up to 40% tumor remissions were achieved with DCs transduced by rSVIL-12 and 73% with DCs expressing IL-15. This antitumor effect correlated with the in vivo priming of tumor-specific CD8+ T lymphocytes. Depletion studies showed that rSVIL-15-mediated antitumor efficacy was mediated mainly by CD8+ T lymphocytes and NK cells. We conclude that (i) SV40-derived vectors are an advantageous alternative to transduce genes into DCs and (ii) DCs transferred with IL-15 have an enhanced capability to induce curative antitumor immunity when injected into malignant lesions.
Immunopathological mechanisms of human T cell lymphotropic virus type 1 (HTLV-I) uveitis. Detection of HTLV-I-infected T cells in the eye and their constitutive cytokine production.
Authors: K Sagawa, M Mochizuki, K Masuoka, K Katagiri, T Katayama, T Maeda, A Tanimoto, S Sugita, T Watanabe, K Itoh
Journal: Journal of Clinical Investigation (1995)

The immunopathology of human T cell lymphotropic virus type 1 (HTLV-I) uveitis was addressed by using T cell clones (TCC) established from the intraocular fluid of patients with HTLV-I uveitis. Proviral DNA of HTLV-I was identified in 55 out of 94 (59%) or 13 out of 36 (36%) TCC from the ocular fluid or the peripheral blood of these patients, respectively. Most of HTLV-I-infected TCC had a CD3+ CD4+ CD8- phenotype. HTLV-I infection on TCC was confirmed by analysis of the viral mRNA, nucleotide sequence, virus-associated proteins, and virus particles. HTLV-I-infected TCC, but not HTLV-I negative TCC, constitutively produced high amounts of IL-6 (1,336 +/- 1,050 pg/ml) and TNF-alpha (289 +/- 237 pg/ml) in the absence of any stimuli. HTLV-I-infected TCC from the ocular lesion also constitutively produced high amounts of IL-1 alpha (12,699 pg/ml), IL-2 (61 pg/ml), IL-3 (428 pg/ml), IL-8 (1,268 pg/ml), IL-10 (28 pg/ml), IFN-gamma (5,095 pg/ml), and GM-CSF (2,886 pg/ml). Hydrocortisone, a drug effective in vivo for the treatment of HTLV-I uveitis, severely depressed cytokine production in vitro in most cases. In summary, the results demonstrated direct evidence of HTLV-I infection of the eye and suggest that cytokines produced by HTLV-I-infected T cells are responsible for the intraocular inflammation in patients with HTLV-I uveitis.
Nitrous Oxide/N2O
Authors: Ronald M. Meyer
Journal: JAMA (1985)

Few drugs in current use have enjoyed such long-standing and widespread popularity as nitrous oxide. Introduced to medicine in the 1840s amid bitter controversy about whom to credit with the discovery of anesthesia, this ubiquitous agent is once again generating heated discussions. Some respected leaders in anesthesiology, such as Dr Eger, favor abandoning nitrous oxide because of possible toxic sequelae of its use. The appearance now of this thorough, balanced, multiauthored monograph will elicit a sigh of relief from the practicing anesthesiologist or dentist who would eschew dogma and evaluate the facts. The chapters progress from traditional to recent topics. Early on, subjects familiar to anesthesiologists are reviewed: pharmacokinetics, cardiovascular effects, respiratory effects, use in obstetrics, and so forth. Four subsequent chapters present established data not as well known to many who practice anesthesia. The reader learns the mechanisms of nitrous oxide metabolism in the body and the nature and
Medical Work in America: Essays on Health Care
Authors: Jeffrey Michael Clair
Journal: JAMA (1990)

Those immediately attracted to this book will be medical sociologists and behavioral scientists. Eliot Freidson, as David Mechanic notes on the book's back jacket, "is one of the most interesting and best known sociologists and his thinking continues to have applicability to current and impending issues." Add to this praise the advertising summaries describing this book as a "series of essays that includes<i>some</i>of his classic work as well as significant<i>new</i>material," (emphasis added) and you have a demand for a fresh and timely book on critical biomedical health care issues. The facts are that this book includes<i>mostly</i>already published works with<i>some</i>new material, making it less attractive to social and behavioral scientists after an initial reading. Oddly enough, health care providers and educators perhaps can offer the best critique of this collection of well-known medical sociology essays. Although the language of medical sociology is unfamiliar
URTICARIA DUE TO SENNA LEAVES
Authors: Lester Hollander
Journal: JAMA (1933)

Mrs. N. J., aged 41, American, a housewife, consulted me, Aug. 5, 1932, on account of an evanescent, extremely itchy eruption which affected her lower extremities, especially her thighs. It began sometime during the month of May, 1932, and was always worse at night and about the time of waking in the morning. The patient stated that about two hours after retiring she would generally wake up on account of the intensity of the itch, and at that time fairly good sized welts would be present on her legs, and they would persist during the night and at times after she got up in the morning. Later during the day the itching would subside, only to return and repeat the cycle during the night. General examination revealed nothing of importance, except the remnants of some scratch marks and a few indefinite wheals, sufficient, however, to make the diagnosis of urticaria.
Carcinoma In Situ Arising in a Gastric Hamartomatous Polyp in a Patient with Peutz-Jeghers Syndrome
Authors: M. R. Defago, A. L. Higa, J. L. Campra, M. Paradelo, A. Uehara, M. H. Torres Mozzucchi, R. Videla
Journal: Endoscopy (1996)
Hope and despair over health in Gaza
Authors: Allan G Hill, Cari Jo Clark, Ismail Lubbad, Claude Bruderlein
Journal: BMJ (2006)

strategies would save not only billions of dollars but thousands of lives, and funds currently spent on intervention and relief could be devoted to enhancing equitable and sustainable development, which would further reduce the risk of war and disaster. 17Recent resolutions endorsed by the World Health Assembly of WHO and the Regional Committee of the Eastern Mediterranean region also emphasise preparedness along with response and are the guiding force behind a number of new initiatives (see bmj.com).Contributors and sources: AM and IS have been extensively involved in emergency preparedness and response related health policy and planning, operations, and research and as first responders in the humanitarian/complex emergencies in the Eastern Mediterranean region.
PROGNOSIS OF PATIENTS WITH ISOLATED SEVERE AORTIC STENOSIS: ARE OUTCOMES SIMILAR FOR ALL PATIENTS WITH AN AORTIC VALVE AREA LESS THAN 1.0 CM 2 ?
Authors: Praveen Mehrotra, Katrijn Jansen, Timothy Tan, Aidan Flynn, Sammy Elmariah, Michael Picard, Judy Hung
Journal: Journal of the American College of Cardiology (2013)
Free radical-mediated activation of hydrazine derivatives.
Authors: B Kalyanaraman, B K Sinha
Journal: Environmental Health Perspectives (1985)

Hydrazines are known to undergo oxidative activation in several enzymatic systems in vitro. Free radicals or carbonium ions have been proposed as active intermediates during such activation. The toxic effects elicited by hydrazines have also been linked to free radical-mediated activation. In this report, we have reviewed the identification of organic free radicals from hydrazines by direct ESR and ESR-spin trapping.
Numerical competence in animals: Definitional issues, current evidence, and a new research agenda
Authors: Hank Davis, Rachelle Pérusse
Journal: Behavioral and Brain Sciences (1988)

Abstract Numerical competence is one of the many aspects of animal cognition that have enjoyed a resurgence of interest during the past decade. Evidence for numerical abilities in animals has followed a tortuous path to respectability, however, from Clever Hans, the counting horse, to modern experimental studies. Recent surveys of the literaturereveal theoretical as well as definitional confusion arising from inconsistent terminology for numerical processes and procedures. The term “counting” has been applied to situations having little to do with its meaning in the human literature. We propose a consistent vocabulary and theoretical framework for evaluating numerical competence. Relative numerousness judgments, subitizing, counting, and estimation may be the essential processes by which animals perform numerical discriminations. Ordinality, cardinality, and transitivity also play an important role in these processes. Our schema is applied to a variety of recent experimental situations. Some evidence of transfer is essential in demonstrating higher-order ability such as counting or “sense of number.” Those instances of numerical competence in which all viable alternatives to counting (e.g., subitizing) have been precluded, but no evidence of transfer has been demonstrated might be described as “protocounting.” To show that animals are capable of “true” counting future research will have to demonstrate generality across situations.
Meckel's Diverticulum:
Authors: Eugene C. Weinstein
Journal: JAMA (1962)

A total of 722 surgical cases of Meckel's diverticulum was encountered at the Mayo Clinic from 1906 through 1960. In 560 cases it was an incidental finding in the course of other surgical procedures, while in 162 cases the diverticulum was the specific cause for surgical intervention. The symptomatic diverticula presented in the following manner: persistent omphalomesenteric fistula (8), component of a hernial sac (9), intussusception (15), inflammation (29), intestinal obstruction excluding intussusception (28), hemorrhage (63), and neoplasm (10). The symptoms of diseased diverticulum are not specific to it alone but rather are characteristic of the pathologic process occurring in it. For this reason, Meckel's diverticulum must be considered as a possible cause of any intra-abdominal condition which cannot be readily diagnosed.
The Yield of the Routine Admission Electrocardiogram
Authors: J. RANDALL MOORMAN
Journal: Annals of Internal Medicine (1985)

To evaluate the usefulness of the admission electrocardiogram, we prospectively studied 1410 patients admitted to a general medical service. The patients' history and physical examination were analyzed, and then the electrocardiogram was evaluated to determine whether it added new information. Fifty-two admission electrocardiograms added unique information; 31 established a new diagnosis, 28 of which changed management. Twenty-one electrocardiograms suggested a new diagnosis, 13 of which proved correct. Only age and a clinically evident cardiac abnormality predicted the yield of the admission electrocardiogram. Among patients with cardiac abnormalities, electrocardiogram yield was 8.5% in those 45 years or older and 2.5% in those younger. Among patients without cardiac abnormality, electrocardiogram yield was 1.0% overall and its cost-effectiveness was $24 000 per year of life saved. An admission electrocardiogram infrequently added new information to the clinical evaluation, but was useful when it did. Admission electrocardiograms are as cost-effective as many accepted medical practices.
Abstract 5477: Multiple BH3 mimetics antagonize anti-apoptotic MCL1 by inducing the endoplasmic reticulum stress response and upregulating the BH3-only protein NOXA
Authors: Tina C. Albershardt, Bethany L. Salerni, Ryan S. Soderquist, Darcy J P Bates, Alexandre A. Pletnev, Alan R. Eastman
Journal: Cancer Research (2011)

Abstract Many small molecules have been designed or discovered that mimic the binding of BH3-only proteins to the hydrophobic groove of anti-apoptotic BCL2 proteins and thus have potential as anticancer agents. For example, ABT-737 preferentially binds and inhibits BCL2 and BCL-XL but not MCL1. It is generally believed that specific inhibitors of anti-apoptotic BCL2 proteins should induce apoptosis in a BAX/BAK-dependent manner. While this is true for ABT-737, many other purported BH3 mimetics have been shown to kill cells in a BAX/BAK-independent manner leading to the conclusion that they function through alternative undefined targets. The selectivity of these BH3 mimetics for BCL2, BCL-XL, or MCL1 has been established in vitro; whether they inhibit these proteins in cells has not been rigorously investigated. In this study, we used a panel of leukemia cell lines to assess the ability of seven putative BH3 mimetics to affect the interaction of BCL2 family members in a cell-based system. We show that ABT-737 is the only BH3 mimetic that inhibits BCL2 in cells as assessed by displacement of BAD from BCL2. The other six BH3 mimetics activated the endoplasmic reticulum (ER) stress response and induced ATF3 resulting in induction of NOXA which binds to and inhibits the anti-apoptotic MCL1 protein. The fact that 6 different compounds, all of which are thought to be BH3 mimetics, can induce ER stress suggests that they may interact with a common target although whether this is a BCL2 family member remains to be established. In most cancer cells, inhibition of either BCL2/X or MCL1 does not acutely induce apoptosis. However, by combining two BH3 mimetics, one that inhibits BCL2 and one that induces NOXA, apoptosis is induced within 6 h in a BAX/BAK-dependent manner. As MCL1 is a major mechanism of resistance to ABT-737, these results suggest a novel strategy to overcome this resistance. In summary, these results identify a novel signaling pathway through which many BH3-mimetics inhibit MCL1 and suggest the potential use of these agents as adjuvants in combination with various chemotherapy strategies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5477. doi:10.1158/1538-7445.AM2011-5477
Squamous Papilloma: Case Report and Review of Literature
Authors: Prashant P Jaju, Prashant V Suvarna, Rajiv S Desai
Journal: International Journal of Oral Science (2010)

Squamous papillomas are common lesions of the oral mucosa with a predilection for the mucosa of the hard and soft palate. As an oral lesion, it raises concern because of its clinical appearance, which may mimic exophytic carcinoma, verrucous carcinoma or condyloma acuminatum. Its pathogenesis is related to human papilloma virus but there is controversy regarding its viral origin. We present a case of squamous papilloma presenting as oral lesion along with a review of the literature.
Maternal Anxiety Associated With Newborn Genetic Screening for Type 1 Diabetes
Authors: Suzanne Bennett Johnson, Amy E. Baughcum, Stacy K. Carmichael, Jin-Xiong She, Desmond A. Schatz
Journal: Diabetes Care (2004)

OBJECTIVE—To describe maternal anxiety associated with newborn genetic screening for type 1 diabetes during the first year after risk notification. RESEARCH DESIGN AND METHODS—Mothers of at-risk infants (n = 435), identified through newborn genetic screening as part of the Prospective Assessment of Newborn for Diabetes Autoimmunity (PANDA) study, were administered a short form of the State Trait Anxiety Inventory (STAI) during telephone interviews ∼3.5 weeks, 4 months, and 1 year after risk notification. Statistical analyses were conducted to examine predictors of maternal anxiety at each interview as well as changes in anxiety over time. RESULTS—For the total sample, initial state STAI scores were not elevated and declined further over time. However, Hispanic mothers, those with low levels of education, those who overestimated the child’s risk for diabetes, and mothers of infants in the highest risk group exhibited significantly elevated initial state STAI scores. At 4 months, higher state STAI scores were associated with higher initial state STAI scores, single parent status, having an infant with a first-degree relative with diabetes, and overestimation of the child’s actual risk. Initial and 4-month STAI scores remained predictive of STAI scores at 1 year. In addition, single mothers and mothers of female children reported higher STAI state scores 1 year after risk notification. CONCLUSIONS—For most mothers, newborn genetic screening to identify infants at increased risk for type 1 diabetes is not associated with significantly elevated maternal anxiety; anxiety further dissipates over time. However, anxiety levels vary considerably as a function of maternal ethnic status, education, marital status, maternal estimation of infant risk, and sex of the child and may be significantly elevated in some women.
THE EFFECT OF MANUAL THROMBUS ASPIRATION OVER ENDOTHELIAL FUNCTION AND INFLAMMATORY MARKERS IN PATIENTS PRESENTING WITH ST-ELEVATION MYOCARDIAL INFARCTION
Authors: Sadik Acikel, Salih Orcan, Ali Yalcindag, Munevver Sari, Furkan H. Sahan, Hamza Sunman, Harun Kilic, Ramazan Akdemir, Ekrem Yeter
Journal: Journal of the American College of Cardiology (2015)
Perivascular Extravasation of Thorium Dioxide Preparation
Authors: Patricia Germon
Journal: JAMA (1963)

IN 1960, a 30-year-old Negro female was first admitted to Hahnemann Hospital because of massive swelling of an amputation stump of the left arm. Radiographic studies at that time revealed what was initially interpreted as calcification of the spleen. The roentgen characteristics were so unusual, however, that extensive inquiries were carried out. The following case report is a recapitulation of clinical events leading to the present syndrome. <h3>Report of a Case</h3> At 12 years of age the patient was first seen at another hospital (1942) because of a congential, progressive enlargement of the left arm and shoulder region and a slight enlargement of the left leg. After routine studies were completed an arteriogram was attempted on the left arm by the percutaneous method. This was unsuccesful and most of the thorium dioxide preparation (Thorotrast) was extravasated into the soft tissues of the arm. She was discharged without being given definitive
Results of Behaviour Therapy in 77 Psychiatric Patients
Authors: J. E. Cooper, M. G. Gelder, I. M. Marks
Journal: BMJ (1965)

JOURNAL3. Punjabi Food.-(a)Thick wheat chapatti with a lot of ghee (butter fat).(b) Dal urd (Phaseolus mungo) is made as a thick viscous curry with spices and chillies and a lot of ghee.(c) Rawan (Vigna sinensis) is made as thick curry after frying the beans ; all the ingredients have a neutral reaction in vitro and no group- specific substances.Punjabi food is taken simmering hot and requires a good deal of mastication.
Informed Consent to Human Experimentation: The Subject's Dilemma
Authors: Robert L. Sadoff
Journal: JAMA (1978)

This is a well-organized, readable book written by three lawyers with experience in medical-legal and hospital law practice. They properly begin with the Nuremberg Code and incorporate historical principles of informed consent to human experimentation, applying their findings to the vulnerable persons in our society, including children, prisoners, the unborn, and the mentally disabled. The authors focus on informed consent as the fulcrum of the relationship of the physician to his patient and to all those involved in medical research. They are careful to define such legal terms as "risk" and to provide us with relative cases, a helpful appendix, and a number of references. In dealing with research with children, the authors developed the concept of proxy consent, ie, consent given by parents or guardians to the minor. They also differentiate between therapeutic research and nontherapeutic research, in which the conditions must be more carefully guarded and explained. The
Higher Cortical Functions in Man
Authors: Wendell J. S. Krieg
Journal: JAMA (1966)

The Russians are far ahead of us in research on the human cerebral cortex. We have been too bemused by the ultralittle to give much attention to the great overbrain. The areal studies of Filimonov, continued into the cortical mechanisms by Polyakov, and functional analysis of the human cerebral cortex by Luria and his many fellow travelers, have volleyed corticology beyond its position in the western world (but they have neglected the important experimentation on higher primates). Luria's earlier work, which concentrated on speech, he now extends to the other activities of the left cerebral cortex. He confesses that his diagnostic ability is not yet adequate for the subtler injuries of the right side. This reviewer finds Luria's categories sound, his testing methods properly evocative, and his judgments well founded. To what degree his testing methods and conceptualization are matched in American psychological research, however, the reviewer cannot say, but
Hispanics With Primary Biliary Cirrhosis Are More Likely to Have Features of Autoimmune Hepatitis and Reduced Response to Ursodeoxycholic Acid Than Non-Hispanics
Authors: Cynthia Levy, Jahnavi Naik, Christin Giordano, Amar Mandalia, Christopher O'Brien, Kalyan R. Bhamidimarri, Eugene R. Schiff, Paul Martin
Journal: Clinical Gastroenterology and Hepatology (2013)
Prepubic Sentinel Node Location in Penile Carcinoma
Authors: Bin K. Kroon, Renato A. Vald??s Olmos, Henk G. van der Poel, Omgo E. Nieweg, Simon Horenblas
Journal: Clinical Nuclear Medicine (2005)

An unusual sentinel node location in a patient with penile carcinoma is described. The preoperative lymphoscintigram showed a prepubic sentinel node. The node could be harvested during surgery. This case illustrates one of the advantages of lymphatic mapping in penile carcinoma: preoperative lymphoscintigraphy can identify lymph nodes outside the usual nodal basins.
BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species–dependent DNA double-strand breaks
Authors: Michal O. Nowicki, Rafal Falinski, Mateusz Koptyra, Artur Slupianek, Tomasz Stoklosa, Ewa Gloc, Margaret Nieborowska-Skorska, Janusz Blasiak, Tomasz Skorski
Journal: Blood (2004)
A novel strategy utilizing ultrasound for antigen delivery in dendritic cell-based cancer immunotherapy
Authors: Ryo Suzuki, Yusuke Oda, Naoki Utoguchi, Eisuke Namai, Yuichiro Taira, Naoki Okada, Norimitsu Kadowaki, Tetsuya Kodama, Katsuro Tachibana, Kazuo Maruyama
Journal: Journal of Controlled Release (2008)