tbuckley/cabot-search huggingface dataset:
Fecal Microbiota Transplantation for<i>Clostridium difficile</i>Infection—Reply
Authors: Ilan Youngster, Elizabeth L. Hohmann
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increased epicardial fat tissue is a marker of subclinical atherosclerosis in patients with psoriasis
Authors: B. Bulbul Sen, N. Atci, E.N. Rifaioglu, O. Ekiz, I. Kartal, E. Buyukkaya, M. Kurt, M.F. Karakas, S. Buyukkaya, A.B. Akcay, N. Sen
Journal: British Journal of Dermatology (2013)

Journal Article Increased epicardial fat tissue is a marker of subclinical atherosclerosis in patients with psoriasis Get access B. Bulbul Sen, B. Bulbul Sen Department of Dermatology Mustafa Kemal University School of Medicine Hatay Turkey Search for other works by this author on: Oxford Academic Google Scholar N. Atci, N. Atci Department of Radiology Mustafa Kemal University School of Medicine Hatay Turkey Search for other works by this author on: Oxford Academic Google Scholar E.N. Rifaioglu, E.N. Rifaioglu Department of Dermatology Mustafa Kemal University School of Medicine Hatay Turkey Search for other works by this author on: Oxford Academic Google Scholar O. Ekiz, O. Ekiz Department of Dermatology Mustafa Kemal University School of Medicine Hatay Turkey Search for other works by this author on: Oxford Academic Google Scholar I. Kartal, I. Kartal Department of Radiology Mustafa Kemal University School of Medicine Hatay Turkey Search for other works by this author on: Oxford Academic Google Scholar E. Buyukkaya, E. Buyukkaya Department of Cardiology Mustafa Kemal University School of Medicine Hatay Turkey Search for other works by this author on: Oxford Academic Google Scholar M. Kurt, M. Kurt Department of Cardiology Mustafa Kemal University School of Medicine Hatay Turkey Search for other works by this author on: Oxford Academic Google Scholar M.F. Karakas, M.F. Karakas Department of Cardiology Mustafa Kemal University School of Medicine Hatay Turkey Search for other works by this author on: Oxford Academic Google Scholar S. Buyukkaya, S. Buyukkaya Department of Cardiology Antakya State Hospital Hatay Turkey Search for other works by this author on: Oxford Academic Google Scholar A.B. Akcay, A.B. Akcay Department of Cardiology Mustafa Kemal University School of Medicine Hatay Turkey Search for other works by this author on: Oxford Academic Google Scholar ... Show more N. Sen N. Sen Department of Cardiology Mustafa Kemal University School of Medicine Hatay Turkey Correspondence Bilge Bulbul Sen. E‐mail: bilgebulbul@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 169, Issue 5, 1 November 2013, Pages 1081–1086, https://doi.org/10.1111/bjd.12569 Published: 01 November 2013
The oncogenicity of azathioprine?
Authors: Fenton Schaffner
Journal: Hepatology (1988)

One hundred and fifty-four patients with histologically verified non-alcoholic chronic liver disease were randomized to azathioprine or prednisone treatment. After a median of 91 months observation time, the cause of death was assessed retrospectively. Autopsy was performed in 82% of 71 deaths. In the azathioprine group 33% (13/39) died from malignant neoplasia, and in the prednisone group (13%) (4/32) (p = 0.08). Considering a possible fatal outcome as a consequence of treatment, this finding urges caution in the long-term application of azathioprine at the usual dose level.
Abstract 1091: Cannabinoids inhibit epidermal growth factor receptor transactivation in lung cancer cells
Authors: Terry W. Moody, Samuel Mantey, Robert T. Jensen, David Wink, Partha Mukhopadhyay, Pal Pacher
Journal: Cancer Research (2012)

Abstract The cannabinoid receptors CB1 and CB2 are present on non-small cell lung cancer (NSCLC) biopsy specimens (Preet et al., 2011, Cancer Prev. Res. 4:65). CP55,940 and Win55,212-2 are mixed agonists which stimulate CB1 and CB2 cannabinoid receptors. G-protein coupled receptors (GPCR) for pituitary adenylate cyclase activating polypeptide (PACAP) regulate epidermal growth factor receptor (EGFR) tyrosine phosphorylation in NSCLC cells. Here the ability of cannabinoids to alter EGFR transactivation was investigated. PACAP stimulated EGFR tyrosine phosphorylation (PY1068) 4-fold using NCI-H838 and H1299 cells. CP55,940 and Win55,212-2 inhibited the ability of PACAP to increase EGFR tyrosine phosphorylation in lung cancer cells. By Western blot, cell lines NCI-H838 and NCI-H1299 had both CB1 and CB2 receptors. PACAP increased cAMP levels in NCI-H838 cells and CP55,940 inhibited the increase in cAMP caused by PACAP. In contrast, PACAP increased cytosolic Ca2+ in lung cancer cells, but CP55,940 did not alter the ability of PACAP to increase calcium in lung cancer cells. These results suggest that CP55,940 may inhibit adenylyl cyclase activity but not phosphatidylinositol turnover caused by addition of PACAP to lung cancer cells. Previously we found that PACAP increased tyrosine phosphorylation of focal adhesion kinase, paxillin and ERK in lung cancer cells (Moody et al., 2002, Reg. Peptides 109:135). CP55,940 inhibited the increase in tyrosine phosphorylation of focal adhesion kinase, paxillin and ERK caused by PACAP addition to lung cancer cells. Also, CP55.940 and Win55,212-2 inhibited the growth of NCI-H1299 and NCI-H838 cells. CP55,940 potentiated the growth inhibitory effects of gefitinib, an EGFR tyrosine kinase inhibitor. These results indicate that cannabinoids inhibit EGFR transactivation in lung cancer cells and potentiate gefitinib cytotoxicity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1091. doi:1538-7445.AM2012-1091
1145 HIGH NUMBERS OF CD56BRIGHT, CD56DIM/NKG2D+ AND LOW NUMBERS OF CD3 CD56 CD16+ NK-CELLS ARE ASSOCIATED WITH LOW HCV-SPECIFIC IL-10 PRODUCTION AND PREDICT TREATMENT-RESPONSE IN CHRONIC HEPATITIS C
Authors: I. Carey, A. Mendes, A. Scalori, D. Joshi, K. Agarwal, G. Mieli-Vergani, D. Vergani
Journal: Journal of Hepatology (2011)
The Thermal Springs of Royat, La Bourboule, and Chatel-Guyon
Authors: G. H. Brandt
Journal: BMJ (1879)

mountain air towards the contraction of the pulmonary capillaries and a certain degree of interference with the pulmonary circulation.Although we had no snow this last winter at Cannes, there was much more ice than usual.The effect of the sea as a source of heat was in- teresting to note; the mud and road-puddles being on several occasions frozen a few hundred yards from the shore, while soft and free from ice at the immediate seaside.The temperature of the surface of the Mediterranean, taken daily at Cannes during the last six winter months, yielded the following monthly mean: I878-79.
Suicide in Psychiatrists
Authors: Manfred Braun
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Basically I tend to agree with Ellerbroek (222:364, 1972) that "professionals in the field should maintain a high index of suspicion as to the validity of psychiatric teachings until we have the lowest suicide rate of any professional group, not the highest." I would like to add that medical students should be made aware of "possible basic conceptual errors in psychiatric knowledge," because quite a few young physicians choose psychiatry as their specialty due to their unconscious needs and conflicts, seeking solutions to their own unconscious problems.
Antidepressant prescribing and suicide: Decline in suicide rate among older people predates 1991
Authors: T. J Verberne
Journal: BMJ (2003)

EDITOR—Hall et al say that the association they observed between antidepressant prescribing and suicide may reflect increased recognition, diagnosis, and treatment of depression by general practitioners as much as any pharmacological effects of antidepressants.1 The time scale they took into …
Carcinomatosis of the Meninges
Authors: K. W. G. Heathfield, J. R. B. Williams
Journal: BMJ (1956)

MEDICAL JOU)RNAL lieno-renal shunt has stopped further attacks of haemat- emesis and has led to considerable regression of the oeso- phageal varices.At operation in Case 4, it was found that the splenic vein was embedded in a pancreatic mass, which was subsequently proved by histological examination of a biopsy specimen to be due to chronic inflammation.The large tortuous colla- terals seen in the venogram actually belonged to the gastro- epiploic system of veins and obviously accounted for the bleeding. SummaryFouLr cases of extrahepatic obstruction of the portal system of veins with repeated severe haematemeses and melaena are described.Two were due to caverno- matous transformation of the portal vein and two to obstruction of the splenic vein by chronic inflammatory pancreatic masses.In three cases splenoportal venography clearly demonstrated the sites of obstruction and their possible nature.Both these findings were subsequently confirmed.In addition to the routine methods of investigation, the advantages of splenoportal venogrephy in such cases, both in diagnosing the cause of haematemesis and in planning the operation, are commented upon.Wc Ire thanklul to Dr. A. K. Datta Gupta, Principal, Nilratall Sircar-Medical Coliege, Calcutta, for allowing us to use the records of the cases here reported.
Are ARID5B and IKZF1 polymorphisms also associated with childhood acute myeloblastic leukemia: the ESCALE study (SFCE)?
Authors: J Rudant, L Orsi, A Bonaventure, S Goujon-Bellec, E Corda, A Baruchel, Y Bertrand, B Nelken, A Robert, G Michel, N Sirvent, P Chastagner, S Ducassou, X Rialland, D Hémon, G Leverger, J Clavel
Journal: Leukemia (2012)
Malar Rash in a Stem Cell Transplant Recipient
Authors: Matthew Mansh, Weilan Johnson, Jennifer Lai
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SAVING OF LARD BY THE DRUGGIST
Authors: Douglas W. Montgomery
Journal: JAMA (1918)

<h3>To the Editor:</h3> —There are about 40,000 druggists in the United States, each of which uses, at a low average, 25 pounds of lard per annum. This means 1,000,000 pounds in all. Much the greater portion of this is used as zinc ointment, the most frequently employed ointment both among the general medical profession and with the laity. Zinc ointment and simple cerate make up the bulk of the apothecarial lard. In both these preparations the petroleum products might be advantageously substituted. In fact, there is such a zinc pomade, put up in tubes, which enjoys a great popularity. If, however, a physician writes a prescription, or a customer asks for zinc oxid ointment, the druggist has no choice—he must, according to the pharmacopeia, dispense an ointment composed of benzoinated lard and zinc oxid, every ounce of which means practically an ounce of lard, enough pork fat, together with the
The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease
Authors: Ignacio Munoz-Sanjuan, Gillian P. Bates
Journal: Journal of Clinical Investigation (2011)

Huntington disease (HD) is a dominantly inherited neurodegenerative disorder that results from expansion of the polyglutamine repeat in the huntingtin (HTT) gene. There are currently no effective treatments for this devastating disease. Given its monogenic nature, disease modification therapies for HD should be theoretically feasible. Currently, pharmacological therapies aimed at disease modification by altering levels of HTT protein are in late-stage preclinical development. Here, we review current efforts to develop new treatments for HD based on our current understanding of HTT function and the main pathological mechanisms. We emphasize the need to enhance translational efforts and highlight the importance of aligning the clinical and basic research communities to validate existing hypotheses in clinical studies. Human and animal therapeutic trials are presented with an emphasis on cellular and molecular mechanisms relevant to disease progression.
Treatment of mastalgia with bromocriptine.
Authors: R E Mansel, J R Wisbey, L E Hughes
Journal: BMJ (1979)

in general practice, so that there are many cimetidine-treated patients in the community with undiagnosed or (if they come up to clinic during or shortly after a course of cimetidine) undiagnosable abdominal pain, some of whom may be harbouring palliated malignancy.It is necessary to emphasise, categorically, that it is in every patient's best interests to have a definitive diagnosis made before treatment with cimetidine is started.There is no doubt that the endoscopic and radiological facilities within the NHS are adequate to cope with the demand.A definitive diagnosis is all the more important since it is clear that prolonged, rather than short-term, cimetidine treatment is necessary for most of these patients with chronic duodenal ulcer disease who are suitable for medical treatment.
Britons are making healthier lifestyle choices than 40 years ago
Authors: I. Torjesen
Journal: BMJ (2013)

British adults are half as likely to smoke as they were four decades ago and are drinking less heavily and less frequently, show data from the Office for National Statistics (ONS) 2011 General Lifestyle Survey.

The survey’s report, launched at a press conference in London on 7 March, also shows that despite the ageing population, the proportion of people in Great Britain living with a longstanding illness or disability has remained steady over the past 20 years at just under a third.1

The 2011 report marks 40 years of the survey. When the ONS survey first included questions about smoking in 1974, it found that 45% of adults smoked …
The renal sympathetic baroreflex in the rabbit. Arterial and cardiac baroreceptor influences, resetting, and effect of anesthesia.
Authors: P K Dorward, W Riedel, S L Burke, J Gipps, P I Korner
Journal: Circulation Research (1985)

Curves relating renal sympathetic nerve activity and mean arterial pressure were derived in conscious rabbits during ramp changes in mean arterial pressure, elicited by perivascular balloon inflation. The renal sympathetic nerve activity-mean arterial pressure relationship consisted of a high-gain sigmoidal region about resting, where renal sympathetic nerve activity rose or fell in response to moderate falls and rises of mean arterial pressure. With larger pressure rises, renal sympathetic nerve activity first fell to a lower plateau and then reversed at even higher mean arterial pressure. When mean arterial pressure was lowered below resting, renal sympathetic nerve activity rose to an upper plateau and then reversed abruptly toward resting at low mean arterial pressure. Both arterial and cardiac baroreceptors exerted substantial inhibitory influences on renal sympathetic nerve activity at all pressure levels. These effects appeared additive over the central high gain region of the curve, but beyond this region there were non-additive interactions. The latter were affected considerably by alfathesin anesthesia. In other experiments, we studied the effects of sustained alterations in resting mean arterial pressure induced by infusing nitroprusside and phenylephrine, which produced rapid resetting of the renal baroreflex. The latter could be accounted for, in part, by resetting of the threshold of the arterial baroreceptors and in part by contributions from other afferents, probably the cardiac receptors. During resetting associated with nitroprusside-induced falls in resting blood pressure, high-gain reflex adjustments in renal sympathetic nerve activity to moderate changes in mean arterial pressure were preserved, but during resetting associated with phenylephrine-induced rises in resting mean mean arterial pressure, the resting renal sympathetic nerve activity lay on the lower curve plateau, resulting in reduction in the apparent gain of the reflex renal sympathetic nerve activity response to moderate changes in mean arterial pressure.
Freon and Hypertension-Reply
Authors: Sorell L. Schwartz
Journal: JAMA (1992)

In Reply.  —We certainly agree with Dr Morton that there is adequate reason to consider chemical exposure as a cause of an observed elevated blood pressure in certain occupational settings. In that regard, the original questioner was appropriately concerned.  Our response was directed at a causal inference method, per se, as well as application of that method to the question posed. We began with the assumption that exposure to Freon was a possible cause of the hypertension in this specific case. We concluded, however, that the probability of such a relationship was too small to justify an inference that the exposure was in fact causal. It was and is our view that existing data (including those cited by Morton) do not, to use a Bayesian term, support a compelling prior probability for the hypothesis that Freon causes elevated blood pressure in general. That, plus the evidence specific to this case,
Propranolol decreases sympathetic nervous activity reflected by plasma catecholamines during evolution of myocardial infarction in man.
Authors: H S Mueller, S M Ayres
Journal: Journal of Clinical Investigation (1980)

Plasma 1-norepinephrine and epinephrine contents were strikingly elevated in 70 patients during evolution of myocardial infarction. Propranolol or placebo, 0.1 mg/kg i.v., was administered randomly an average of 10 h after infarction and continued orally for 3 d. Propranolol, but not placebo, acutely decreased 1-norepinephrine contents from 2.24 +/- 1.33 (mean +/- SD) to 1.31 +/- 0.74 microgram/liter, P less than 0.001, and epinephrine contents from 0.97 +/- 0.42 to 0.74 +/- 0.42 microgram/liter, P less than 0.02. Decreases in 1-norepinephrine contents were related to the initial plasma concentrations, r = 0.85, P less than 0.001. A similar, but less strong relationship was observed between the initial epinephrine contents and propranolol-induced changes, r = -0.51, P less than 0.01. Propranolol reduced plasma-free fatty acid contents from 1,121 +/- 315 to 943 +/- 274 mumol/liter, P less than 0.001. Decreases in plasma contents of free fatty acids were related to decreases in epinephrine, r = 0.66, P less than 0.001. Propranolol did not cause significant additional changes in plasma catecholamine contents during the subsequent 3 d. In the placebo group 1-norepinephrine contents had decreased 24 h after infarction from 1.92 +/- 0.99 to 1.37 +/- 0.93 microgram/liter, P less than 0.02. Plasma epinephrine contents did not change. Heart rate remained below the control values during the entire study period in the propranolol, but increased in the placebo group. The data indicate that sympathetic hyperactivity, indirectly reflected by plasma catecholamine contents, is acutely reduced by propranolol during evolution of myocardial infarction.
Cyanosis in Infants Caused by Nitrates in Well Water
Authors: Hunter H. Comly
Journal: JAMA (1987)

Two examples of a previously unrecognized condition which may be confused with congenital heart disease are cited in this report. The condition may occur anywhere in rural areas where well water is used in infant feeding. <h3>REPORT OF CASES</h3><h3>Case 1.—</h3> C. H., a white female baby, was born two weeks before the expected date by cesarean section because of toxemia of pregnancy, which had been severe for one month. The birth weight was 3,870 Gm. (8 pounds 8 ounces). There was no known neonatal distress. On the twelfth day after birth, when she left the hospital, she weighed 3,720 grams (8 pounds 3 ounces). The formula she was receiving at that time was evaporated milk 210 cc. and water 540 cc. with 30 Gm. of a dextrin-maltose preparation. She was admitted to a local hospital at 18 days of age because of vomiting, excessive crying and failure to gain
Effect of Accessory Pulmonary Blood Flow on Survival After the Bidirectional Glenn Procedure
Authors: R. D. Mainwaring, J. J. Lamberti, K. Uzark, R. L. Spicer, M. W. Cocalis, J. W. Moore
Journal: Circulation (1999)

The bidirectional Glenn procedure (BDG) is used in the staged surgical management of patients with a functional single ventricle. Controversy exists regarding whether accessory pulmonary blood flow (APBF) should be left at the time of BDG to augment systemic saturation or be eliminated to reduce volume load of the ventricle. The present study was a retrospective review of patients undergoing BDG that was conducted to assess the influence of APBF on survival rates.From 1986 through 1998, 149 patients have undergone BDG at our institution. Ninety-three patients had elimination of all sources of APBF, whereas 56 patients had either a shunt or a patent right ventricular outflow tract intentionally left in place to augment the pulmonary blood flow provided by the BDG. The operative mortality rate was 2.2% without APBF and 5.4% with APBF. The late mortality rate was 4.4% without APBF and 15.1% with APBF. Actuarial analysis demonstrates a divergence of the Kaplan-Meier curves in favor of patients in whom APBF was eliminated (P<0.02). One hundred seven patients have subsequently undergone completion of their Fontan operation, so the actuarial analysis includes the operative risk of this second operation.The results suggest that the elimination of APBF at the time of BDG may confer a long-term advantage for patients with a functional single ventricle.