tbuckley/cabot-search huggingface dataset:
Government must do more to support war veterans, MPs say
Authors: Helen Mooney
Journal: BMJ (2008)

The government must do more to support war veterans and the families of service personnel, says a report published by the House of Commons Defence Select Committee.

The report, published on Monday, has found that although the clinical care of servicemen and servicewomen injured in manoeuvres is “world class,” more needs to be done to help veterans and the families of personnel in the armed services, particularly in the provision of mental health services.

The chairman of the committee, James Arbuthnot (Conservative MP for Hampshire North East) said that the Ministry of Defence (MoD) needed to …
Antiinflammatory and antiangiogenetic effect of ramiprilat: Angiotensin converting enzyme inhibition in monocytes prevents their angiotensin II- and hypoxia-induced cytokine expression by downregulation of AT-1 receptor expression and NF-kappaB activation
Authors: Alexander Schmeisser, Oliver Soehnlein, Thomas Illmer, Christoph Garlichs, Hannes Lorenz, Gerhard Ehninger, Werner G. Daniel, Ruth H. Strasser
Journal: Journal of the American College of Cardiology (2003)
HLA gene amplification and hybridization analysis of polymorphism. HLA matching for bone marrow transplantation of a patient with HLA-deficient severe combined immunodeficiency syndrome.
Authors: L A Baxter-Lowe, J B Hunter, J T Casper, J Gorski
Journal: Journal of Clinical Investigation (1989)

The treatment of choice for certain immunodeficiency syndromes and hematological disorders is bone marrow transplantation (BMT). The success of BMT is influenced by the degree of HLA compatibility between recipient and donor. However, aberrant expression of HLA sometimes makes it difficult, if not impossible, to determine the patient's HLA type by standard serological and cellular techniques. We describe here the application of new molecular biological techniques to perform high resolution HLA typing independent of HLA expression. A patient with HLA-deficient severe combined deficiency was HLA typed using in vitro amplification of the HLA genes and sequence-specific oligonucleotide probe hybridization (SSOPH). Two major advances provided by this technology are:detection of HLA polymorphism at the level of single amino acid differences; and elimination of a requirement for HLA expression. Although the patient's lymphocytes lacked class II HLA proteins, polymorphism associated with DR7,w53;DQw2;DRw11a (a split of DR5), w52b (a split of DRw52);DQw7 were identified. The patient's class I expression was partially defective, and typing was accomplished by a combination of serological (HLA-A and -C) and SSOPH analysis (HLA-B). Complete patient haplotypes were predicted after typing of family members [A2;B35(w6); Cw4; DRw11a(w52b);DQw7 and A2;B13(w4); Cw6;DR7(w53); DQw2]. Potential unrelated donors were typed and a donor was selected for BMT.
Long-term mortality and recurrence after colorectal cancer surgery with preoperative stenting: a Danish nationwide cohort study
Authors: Rune Erichsen, Erzsébet Horváth-Puhó, Jacob Jacobsen, Tove Nilsson, John Baron, Henrik Sørensen
Journal: Endoscopy (2015)

<b>Background and study aims:</b> Self-expanding metal stents (SEMS) used as a bridge to surgery for obstructive colorectal cancer (CRC) have fallen under suspicion for inducing tumor dissemination, and thereby increasing recurrence risk and long-term mortality. The aim of this study was to compare overall mortality and CRC recurrence in patients receiving preoperative SEMS vs. patients undergoing urgent resection. <b>Patients and methods:</b> This was a Danish, nationwide, population-based cohort study (2005 – 2010). For patients with CRC who survived the first 30 days after resection, the long-term survival in terms of mortality rate ratios was assessed using Cox regression with adjustment for important covariates. For patients with Dukes' A – C disease only, recurrence risk was similarly assessed using incidence rate ratios. <b>Results:</b> The 5-year survival was 49 % among 581 patients with preoperative SEMS and 40 % among 3333 patients undergoing urgent resection, corresponding to an adjusted mortality rate ratio of 0.98 (95 % confidence interval [CI] 0.90 to 1.07). For patients with Dukes' stage A – C disease, the 5-year recurrence risk was 39 % among 286 patients after preoperative SEMS and 30 % among 1627 patients after urgent resection, corresponding to an adjusted incidence rate ratio of 1.12 (95 %CI 0.99 to 1.28). <b>Conclusions:</b> Long-term mortality associated with the use of SEMS as a bridge to surgery was comparable to that of urgent resection. SEMS use may be associated with an increased CRC recurrence risk.
The History of the Full-Time Clinical Faculty System
Authors: Richard L. Landau
Journal: JAMA (1991)

<h3>To the Editor.</h3> —Fye's scholarly article<sup>1</sup>on the history of the full-time faculty system is marred by a striking omission. There is no mention whatever of the first<i>completely</i>full-time clinical faculty in America, the University of Chicago (Ill). This pioneering clinical facility, located on the campus of the university, opened its doors in 1927.<i>All</i>members of the clinical departments were full-time and salaried. The departments and their faculties were fully integrated into the university as biologic science departments. The survival of this full-time organization, despite the handicaps of the Great Depression and the hostility of Chicago's organized medicine, can be ascribed to the dedication of a remarkable faculty and the support of the entire university. Surely it was the success, indeed the distinction, achieved by these initial full-time departments that encouraged other medical schools to follow suit during the years after World War II. The much-feared financial
Serum TSH Levels and the Thyroidal Response to TSH Stimulation in Patients with Thyroid Disease
Authors: JERALD C. NELSON
Journal: Annals of Internal Medicine (1972)

The correlation between serum levels of human thyrotrophin (HTSH) and thyroidal response to bovine thyrotrophin (BTSH) stimulation was studied in patients with nontoxic thyroid disorders. All patients with primary hypothyroidism had elevated HTSH levels and either absent or borderline response to BTSH stimulation. Euthyroid patients with thyroid disease fell into four categories: normal HTSH and normal stimulation by BTSH; normal HTSH and no stimulation by BTSH; elevated HTSH and normal stimulation by BTSH; and elevated HTSH and no stimulation by BTSH. In some diffuse goiter patients there was a dissociation between the protein-bound iodine response and the radioactive iodine response to BTSH. There was no evidence of a "short-loop" feedback suppression of HTSH by BTSH. Elevated HTSH levels in goitrous patients may not necessarily indicate either hypothyroidism or a loss of normal responsiveness to BTSH stimulation.
Relapses and Remissions in Brain Stem Tumours
Authors: N. B. S. Sarkari, E. R. Bickerstaff
Journal: BMJ (1969)

Three cases of brain stem astrocytoma and one of a para-stem vascular tumour are described, each showing a history of relapses and remissions. The diagnoses were confirmed by necropsy, and it is suggested that the relapsing course may have been due to oedema and necrosis in both the tumour and the surrounding brain tissue. Features indicating repeated recurrence of a lesion at the same site in the brain stem justify full neuroradiological investigation before a diagnosis such as multiple sclerosis can be accepted.
Direct Injection of Kit Ligand-2 Lentivirus Improves Cardiac Repair and Rescues Mice Post–myocardial Infarction
Authors: Koji Higuchi, Bilal Ayach, Takeya Sato, Manyin Chen, Sean P Devine, Vanessa I Rasaiah, Fayez Dawood, Teruyuki Yanagisawa, Chuwa Tei, Toshihiro Takenaka, Peter P Liu, Jeffrey A Medin
Journal: Molecular Therapy (2008)

Myocardial infarction (MI) and subsequent adverse remodeling cause heart failure. Previously we demonstrated a role for Kit ligand (KL) in improving cardiac function post-MI. KL has two major isoforms; KL-1 is secreted whereas KL-2 is predominantly membrane bound. We demonstrate here first that KL-2-deficient mice have worse survival and an increased heart/bodyweight ratio post-MI compared to mice with reduced c-Kit receptor expression. Next we synthesized recombinant lentiviral vectors (LVs) that engineered functional expression of murine KL-1 and KL-2. For in vivo analyses, we directly injected these LVs into the left ventricle of membrane-bound KL-deficient Sl/Sl(d) or wild-type (WT) mice undergoing MI. Control LV/enGFP injection led to measurable reporter gene expression in hearts. Injection of LV/KL-2 attenuated adverse left ventricular remodeling and dramatically improved survival post-MI in both Sl/Sl(d) and WT mice (from 12 to 71% and 35 to 73%, respectively, versus controls). With regard toward beginning to understand the possible salutary mechanisms involved in this effect, differential staining patterns of Sca-1 and Ly49 on peripheral blood (PB) cells from therapeutically treated animals was found. Our data show that LV/KL-2 gene therapy is a promising treatment for MI.
Absence of an association between ankylosing spondylitis and IgA nephropathy.
Authors: M.A van de Laar, H.J Moens, J.K van der Korst
Journal: Annals of the Rheumatic Diseases (1989)

Anaemia in rheumatoid arthritis SIR, The unreferenced assertion by Farah, Sturrock, and Russell that iron deficiency anaemia is a common feature of rheumatoid arthritis and is often caused by an asympto- matic peptic ulcer' should not go unchallenged.The diagnosis of iron deficiency in patients with inflammatory disease is difficult, unless bone marrow estimations of iron stores are performed.Perhaps the authors would care to support the statement regarding the prevalence of iron deficiency in rheumatoid arthritis with a suitable reference.In our experience upper gastrointestinal lesions, including asymptomatic peptic ulceration, are common in patients taking non-steroidal anti-inflammatory drugs and are found no more frequently in patients whose anaemia is microcytic, or those with positive faecal occult bloods, than in those with a normocytic anaemia or negative faecal occult bloods.2This observation together with other evidence3 strongly suggests that upper gastrointestinal lesions are not the cause of iron deficiency when it does occur in rheumatoid arthritis.The mere coincidence of two abnormalities does not imply any causal association.
467 Central nervous system involvement in HCV-cryoglobulinemia vasculitis: A multicenter case-control study using MRI and neuropsychological tests
Authors: M. Casato, D. Saadoun, A. Marchetti, C. Picq, P. Pantano, D. Dormont, M.C. Piatella, P. Duhaut, R. Ciancil, M. Fiorilli, J.C. Piette, P. Cacoub
Journal: Journal of Hepatology (2004)
The Effect of Acidosis on Sympatho-adrenal Stimulation
Authors: James R. Malm
Journal: JAMA (1966)

Stimulation of the the sympatho-adrenal system and catecholamine production are induced by several factors accompanying shock. The role of hypotension in evoking this response has been thoroughly investigated. Stimulation of epinephrine and norepinephrine in response to shock has been previously documented, both in experimental work and in clinical situations.<sup>1</sup>The important role of acidosis has been less well elucidated. This report summarizes recent work in this institution, related to the role of acidosis in the stimulation of a sympathoadrenal system, as measured by plasma catecholamine levels. Three experimental models were studied to elucidate clinical observations made during cardiopulmonary bypass. The first series of experiments previously reported by Manger et al<sup>2</sup>were designed to elucidate the effects of acid-base control on the sympathoadrenal response following irreversible hemorrhagic shock. Shock was produced in mongrel dogs with the preparation described by Wiggers,<sup>3</sup>with maintenance of mean arterial-blood pressure of 50
LONG PULSED ULTRASOUND-ENHANCED THROMBOLYSIS: A NEW THERAPY FOR MYOCARDIAL NO-REFLOW
Authors: Xianghui Chen, Francois Yu, Flordeliza Villanueva, Jonathan Leeman, Xucai Chen, Jianjun Wang, Judith Brands, Frederick Schnatz, Yili Liu, Zicheng Li, John Pacella
Journal: Journal of the American College of Cardiology (2013)
Dorothy Cecily Clift
Authors: P. Alderson
Journal: BMJ (2014)

Questionnaires will be adequately filled in by patients if they are properly motivated and will provide useful information. We have found that when patients come for further consultations, much useful information is readily available from these cards to any doctor. We think that this data helps to establish the basis of a good doctor-patient relationship. The trainees in the Watford area were concerned about the lack of family and social history contained in patients9 records which may have been known by the partners, but was often not committed to paper and, if in the notes, was usually not easily found. As a pilot study we decided to design a card to overcome some of these problems, and to test the acceptability and benefit of this method on newly registered patients. The project was also planned as a learning situation for trainees.
Presence of C5a‐potentiating activity in the plasma of a patient with Kimura's disease
Authors: M. Abe, K. Tanaka, J. Kudo, Y. Fukuoka, N. Hara
Journal: Allergy (1994)

To determine whether the response to the active complement fragment C5a in polymorphonuclear leukocytes (PMN) obtained from a patient with Kimura's disease is similar to that in normal subjects, we evaluated superoxide anion (O 2 ‐ ) generation after stimulation with C5a. The patient's PMN produced more O 2 ‐ than did those from healthy controls after stimulation with human C5a in vitro. The response returned to normal with the improvement in clinical indicators after initiation of steroid administration. We conducted the following experiments with the plasma of this patient during the active disease stage to establish the presence of a humoral factor that potentiated the C5a‐response of PMN. Incubation of PMN from normal controls having the same blood type as the patient at 37°C for 2 h with the patient's plasma at the active disease stage revealed that the cells generated abundant O 2 ‐ after stimulation with C5a. Incubation of normal PMN with the patient's plasma during the inactive disease stage showed no potentiated response to C5a. This activity was lost after incubation at 56°C for 30 min. Coincubation of PMN with methylprednisolone up to 100 μg/ml did not suppress this activity. Although the plasma concentration of C5a at the active stage was mildly elevated (13 ng/ml), it was below the limit of detection (&lt;10 ng/ml) at the inactive stage. These results suggest the presence of a heat‐labile, humoral factor in the patient's plasma that upregulated the response of PMN to C5a and that was not suppressed by in vitro treatment with a steroid. This factor may influence the acute inflammatory reaction in this disorder.
1052-220 Safety and efficacy of catheter ablation of atrial fibrillation using an irrigated-tip ablation catheter
Authors: Chandrasekhar R Vasamreddy, Vinod Jayam, Lars Lickfett, David Bradley, Khurram Nasir, Zayd Eldadah, Timm Dickfeld, Kevin Donahue, Ronald Berger, Hugh Calkins
Journal: Journal of the American College of Cardiology (2004)
William Alexander Werrell (1893-1964)
Authors: WILLIAM S. MIDDLETON
Journal: Annals of Internal Medicine (1965)

Editorials1 January 1965William Alexander Werrell (1893-1964)WILLIAM S. MIDDLETON, M.D., M.A.C.P.WILLIAM S. MIDDLETON, M.D., M.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-174 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"Members of the board come, faithfully and effectively discharge their duties for set terms, and retire with a gratifying sense of a substantial contribution to the commonwealth. Dr. Werrell is the golden thread of continuity. Deeply steeped in the mores and traditions of the Board, he is more than the stabilizing administrator. His idealism, vision and perceptive grasp of the mission of the Board have won the universal respect, the high esteem and the affection of his associates."1While this characterization published before his death epitomizes Bill Werrell's unique relationship to the American Board of Internal Medicine, the occasion requires...1 MiddletonBierring WSWL, and the American Board of Internal Medicine, Journal-Lancet, 83: 466 (Dec.) 1963. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Madison, Wisc. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1965Volume 62, Issue 1Page: 174-176KeywordsHand strengthVision Issue Published: 1 January 1965 PDF DownloadLoading ...
Effects of lifestyle modification on metabolic parameters and carotid intima-media thickness in patients with type 2 diabetes mellitus
Authors: So Hun Kim, Suk Jeong Lee, Eun Seok Kang, Shinae Kang, Kyu Yeon Hur, Hyun Joo Lee, Chul Woo Ahn, Bong Soo Cha, Ji Soo Yoo, Hyun Chul Lee
Journal: Metabolism (2006)
Molecular diagnosis and monitoring in the clinical management of patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors
Authors: Joyce Ou, Jo‐Anne Vergilio, Adam Bagg
Journal: American Journal of Hematology (2007)

Abstract The well‐established molecular pathogenesis of chronic myelogenous leukemia (CML) and its consequences for laboratory testing and clinical management illustrate a classic paradigm for the importance of molecular diagnostics in targeted drug therapy. The success of the tyrosine kinase inhibitor (TKI), imatinib, as the currently recommended first‐line treatment of early chronic phase CML has both fueled the need for timely and reproducible molecular testing of the BCR‐ABL1 fusion transcript in diagnosis and monitoring as well as necessitated the detection of kinase domain mutations that confer resistance to this agent. As, ongoing research continues to refine guidelines for monitoring residual disease in patients undergoing TKI therapy, an understanding of molecular technologies and their interpretation is critical. This review summarizes the molecular strategies that are currently employed in the initial diagnosis and subsequent management of CML patients maintained on TKI therapy. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
In vivo evidence for adriamycin-induced uncoupling of endothelial nitric oxide synthase
Authors: Damon Duquaine, Glenn Hirsch, Anjan Chakrabarti, B. Kalayanaraman, Joy Joseph, Christine Kehrer, Robert D. Brook, Jeanette Vasquez-Vivar, Sanjay Rajagopalan
Journal: Journal of the American College of Cardiology (2003)
Vitamin D: some perspective please
Authors: N. C. Harvey, C. Cooper
Journal: BMJ (2012)

Health claims are ahead of the evidence

Vitamin D deficiency has been associated with an ever expanding list of diseases, and with this has come almost tonic-like claims for vitamin D supplementation. In observational studies, low vitamin D status has been associated with increased risk of multiple sclerosis, type 1 and type 2 diabetes, cardiovascular disease, colon cancer, breast cancer, autoimmunity, and allergy.1 The UK government has advised that all pregnant women, and children under 5 years, should take 400 IU vitamin D daily; a recent news story, however, reported a survey conducted by a charity which suggested that only 26% of pregnant women and 46% of healthcare professionals are aware of these guidelines.2 The most recent musculoskeletal trend seems to be the attribution of childhood problems such as Blount’s disease and slipped femoral epiphyses to vitamin D deficiency and the incorrect conflation of rickets with low serum calcidiol (25-hydroxyvitamin D3) concentrations.3 So are health professionals causing ill health through their lack of awareness and advocacy of vitamin D supplementation?

The high profile news coverage and the enthusiastic promotion of the results of observational studies as though they proved …
Coevolution of immunoglobulin heavy- and light-chain variable-region gene families
Authors: T. Sitnikova, C. Su
Journal: Molecular Biology and Evolution (1998)

The gene families encoding the immunoglobulin variable regions of heavy (VH) and light (VL) chains in vertebrates are composed of many genes. However, the gene number and the extent of diversity among VH and VL gene copies vary with species. To examine the causes of this variation and the evolutionary forces for these multigene families, we conducted a phylogenetic analysis of VH and VL genes from the species of amniotes. The results of our analysis showed that for each species, VH and VL genes have the same pattern of clustering in the trees, and, according to this clustering pattern, the species can be divided into two groups. In the first group of species (humans and mice), VH and VL genes were extensively intermingled with genes from other organisms; in the second group of species (chickens, rabbits, cattle, sheep, swine, and horses), the genes tended to form clusters within the same group of organisms. These results suggest that the VH and VL multigene families have evolved in the same fashion: they have undergone coordinated contraction and expansion of gene repertoires such that each group of organisms is characterized by a certain level of diversity of VH and VL genes. The extent of diversity among copies of VH and VL genes in each species is related to the mechanism of generation of antibody variety. In humans and mice, DNA rearrangement of immunoglobulin variable, diversity, and joining-segment genes is a main source of antibody diversity, whereas in chickens, rabbits, cattle, sheep, swine, and horses, somatic hypermutation and somatic gene conversion play important roles. The evolutionary pattern of VH and VL multigene families is consistent with the birth-and-death model of evolution, yet different levels of diversifying selection seem to operate in the VH and VL genes of these two groups of species.
SUPPRESSION OF CELL-MEDIATED IMMUNITY TO INFECTION BY AN ANTIMITOTIC DRUG
Authors: R. J. North
Journal: The Journal of Experimental Medicine (1970)

The development of acquired cell-mediated immunity to infection with Listeria monocytogenes can be blocked by a 15 hr pulse of the antimitotic drug, vinblastine (Vb). The drug has no effect on the host-parasite relationship after 72 hr of infection when a high level of immunity is being expressed, i.e., when infective foci are populated by activated macrophages. Infective foci in mice treated early during infection with Vb do not acquire migrant macrophages, but they become acellular after 48 hr of infection. The results indicate that Vb destroys the dividing precursors of migrant macrophages. The possibility that Vb prevents the activation of these cells by destroying dividing lymphoid cells engaged in the specific immunological phase of the host response is also considered.
Martin Luther and Drowning of Children
Authors: Paul W. Pruyser
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Paul W. Pruyser wrote that "Luther advocated the drowning of mentally retarded children and much of the splendid 16th and 17th centuries linked mental illness with demoniacal possession, with treatment appropriate to that diagnosis." (<b>195</b>:197, 1966). I wonder what his authority is for making this statement. I myself had heard this statement so often that it has been a part of my childhood training, as it were, and as I wrote to another correspondent who was apparently disturbed by it, one should not feel shocked by this utterance of Luther. A concise statement is given by Leo Kanner.<sup>1</sup>He in turn refers to the two editions of Luther's collected works, including his<i>Table Talk</i>.<sup>2,3</sup> Luther shared this attitude with other leading minds of his time, although he probably gave more forthright expression to it than some of his contemporaries. We frequently forget that the