tbuckley/cabot-search huggingface dataset:
Hearing Loss in Rocky Mountain Spotted Fever
Authors: STEPHEN DOLAN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 February 1986Hearing Loss in Rocky Mountain Spotted FeverSTEPHEN DOLAN, M.D., E. DALE EVERETT, M.D., LISA RENNER, M.A.STEPHEN DOLAN, M.D.Search for more papers by this author, E. DALE EVERETT, M.D.Search for more papers by this author, LISA RENNER, M.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-285_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor; Hearing loss is reported infrequently as a symptom associated with Rocky Mountain spotted fever (1, 2). We have recently seen such a patient in whom hearing loss was documented by audiometry to be a bilateral, moderate sensorineural deficit.A 21-year-old man was hospitalized with a 10-day history of fever, headache, and myalgias. Four days earlier he had noted diminished auditory acuity without tinnitus. He had recently traveled through North Carolina and recalled a tick bite. Examination showed a temperature of 39.4 °C, right subconjunctival hemorrhage, and maculopapular rash involving the palms, soles, and abdomen. Otoscopic findings were...References1. HELMICKBERNARDD'ANGELO CKL. Rocky Mountain spotted fever: clinical, laboratory and epidemiological features of 262 cases. J Infect Dis. 1984;150:480-7. CrossrefMedlineGoogle Scholar2. KAPLOWITZFISCHERSPARLING LJF. Rocky Mountain spotted fever; a clinical dilemma. In: REMINGTON JS, SWARTZ MN, eds. Current Clinical Topics in Infectious Diseases. Vol. 2. New York: McGraw Hill Book Co.; 1982:89-108. Google Scholar3. WALKERMATTERN DW. Rickettsial vasculitis. Am Heart J. 1980;100:896-906. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Missouri-Columbia Columbia, MO 65212 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBILATERAL SUDDEN SENSORINEURAL HEARING LOSS IN SCRUB TYPHUSTRAF1 knockdown alleviates palmitate-induced insulin resistance in HepG2 cells through NF-κB pathwayPegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in BrazilReversible hearing impairment: delayed complication of murine typhus or adverse reaction to azithromycin?Sensorineural Hearing Loss in AdultsAcute sensorineural hearing loss and severe otalgia due to scrub typhusRocky Mountain Spotted Fever 1 February 1986Volume 104, Issue 2Page: 285-285KeywordsFeversHeadachesHearingHemorrhageMyalgiaRashesRocky Mountain spotted feverTemperatureTicksTinnitus Issue Published: 1 February 1986 PDF DownloadLoading ...
Sex on the agenda
Authors: N. Duncan
Journal: BMJ (1996)

The BMA's annual representative meeting has come to expect its deliberations to attract extensive media publicity. Last week's conference was no exception, with daily headlines on the NHS Titanic, the medical workforce crisis, and confidentiality.

But what really took the media's fancy was an obscure motion from Leicestershire and Rutland, tucked away at the back of the agenda, calling for an end to the automatic suspension of doctors who have consensual sexual relations with their patients. The result was a succession of racy headlines–“Chastity in the surgery”; “It's a doctor's affair”; and “GPs want safer sex”–that unexpectedly kept the media spotlight on the conference for a full six days.

By the end of the conference some representatives were grumbling at the media for hijacking the agenda, exaggerating a relatively small issue out of all proportion, and misrepresenting the facts.

Although no strangers to such accusations, the media were, on this occasion at least, not guilty. Indeed, an analysis of their week's outpourings shows that they treated …
Abstract 3767: Familial colorectal cancer registry in Hispanics: A feasibility study
Authors: Yaritza Diaz-Algorri, Leilani Joy, Raisa Balbuena-Merle, Delma Acosta, Cristina Nunez, Mariela Torres-Cintron, Nayda Figueroa-Valles, Alberto Cardona, Mercedes Lacourt-Ventura, Raul Bernabe-Dones, Reynold Lopez-Enriquez, Robert Haile, Rafael Mosquera-Fernandez, APG Members, Marcia Cruz-Correa
Journal: Cancer Research (2011)

Abstract BACKGROUND: In Puerto Rico (PR), colorectal cancer (CRC) represents the second most common cause of cancer in men and women. Incidence and mortality of CRC are increasing in Puerto Rican Hispanics, especially among young individuals. Screening rates for CRC are lower in Hispanic-American individuals compared to non-Hispanic patients. However, there is limited data on genetic epidemiological CRC disparities in Hispanic patients. OBJECTIVES: (1) To prospectively identify and recruit 30 probands with a family history of CRC and 15 family-history negative (2) To prospectively identify and recruit selected relatives from the 45 probands. METHODS: Eligible cases are Hispanic patients with incident diagnosis of CRC, ≥ 21 years old. We identified the probands and their selected family members using the Puerto Rico Central Cancer Registry from July 1, 2007 to the present. PRELIMINARY DATA AND RECRUITMENT: Seven hundred and fifty-one communications were sent to the physicians, three hundred and seventy-four communications were responded (374/751=49.8%).Three hundred and forty-one communications were sent to the patients, one hundred and forty-seven letters were responded (147/341=43.1%) and 16 refused. One hundred and fifty-nine participants (probands and relatives) were enrolled. One hundred and two probands (mean age 56.9 ±13.3 yrs., 54.9% male); 30 with and 72 without family history of CRC. At present, we collected 153 (96.2%) risk factors questionnaires, 135 (84.9%) blood samples and 60 (52.6%) blocks of tissue. CONCLUSIONS: Successful implementation of logistics for identification of incident CRC through the PR Central Cancer Registry during a three-year period. We established the first Familial CRC island-wide registry in Puerto Rico through the implementation of a network of community physicians, laboratories and professional societies. We are developing a tissue and blood bank with epidemiological, nutritional, and demographic data that will assist us to understand the genetic epidemiology of CRC in Puerto Ricans. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3767. doi:10.1158/1538-7445.AM2011-3767
Respiratory Arrest Following Retrobulbar Anesthesia
Authors: John R. Wittpenn, Peter Rapoza, Paul Sternberg, Laurie Kuwashima, James Saklad, Arnall Patz
Journal: Ophthalmology (1986)

Respiratory arrest is a serious complication of retrobulbar anesthesia. We have prospectively followed 3123 retrobulbar injections to determine the incidence of respiratory arrest and identify possible risk factors. Injections contained either 2% or 4% lidocaine with 0.75% bupivacaine (Marcaine) in a 50:50 mixture by volume (total 10 cc.) to which a 1 ml ampule of hyaluronidase (150 NF units) was added. Use of 4% lidocaine gave a significantly higher incidence of respiratory arrest than 2% lidocaine (0.79% vs. 0.09%; P = 0.003, Fisher's exact test). Serum levels of lidocaine and bupivacaine of patients who arrested were not elevated significantly compared to 20 control patients. All levels were well below accepted levels of toxicity. Thus, 4% lidocaine increases the risk of respiratory arrest. These results suggest the mechanism is not direct intravascular or central nervous system injection.
Sciatica or spinal lymphoma
Authors: F Morcos
Journal: Annals of the Rheumatic Diseases (2002)

The involvement of the central nervous system and vertebrae by low grade non-Hodgkin's lymphoma is rare.1 In a previous “lesson of the month”2 in this journal, it was implied that there is always a bad prognosis for patients with spinal lymphoma; however, milder cases may also occur.

A 71 year old man presented to us in January 2000 with a three month history of severe low back pain affecting mainly the left lumbar area and buttock, radiating to the outer aspect of the left thigh and calf. He did not have bladder symptoms or history of recent falls. On examination, he looked well; there was no lymphadenopathy. He had restricted back movement with tenderness of lower lumbar …
A depressed gorilla
Authors: Olimpia Claudia Pop
Journal: BMJ (2007)

My secretary said: “There is a very unusual patient…” (being a psychiatrist, however, I don't find “unusual patients” really come as a surprise to me) “a gorilla, an agitated gorilla.” 

“Is it in A&E?” I blurted out. 

“No, no, it's in the zoo. The vet wants your advice.”

The whole unit soon knew the story: the consultant in whose catchment area the zoo fell claimed it should be his patient, one colleague asked in …
Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia
Authors: Sayoko Doisaki, Hideki Muramatsu, Akira Shimada, Yoshiyuki Takahashi, Makiko Mori-Ezaki, Masanori Sato, Hiroyuki Kawaguchi, Akitoshi Kinoshita, Manabu Sotomatsu, Yasuhide Hayashi, Yoko Furukawa-Hibi, Kiyofumi Yamada, Hideaki Hoshino, Hitoshi Kiyoi, Nao Yoshida, Hirotoshi Sakaguchi, Atsushi Narita, Xinan Wang, Olfat Ismael, Yinyan Xu, Nobuhiro Nishio, Makito Tanaka, Asahito Hama, Kenichi Koike, Seiji Kojima
Journal: Blood (2012)
Frequent Mutation in the ABCC6 Gene (R1141X) Is Associated With a Strong Increase in the Prevalence of Coronary Artery Disease
Authors: Mieke D. Trip, Yvo M. Smulders, Jurgen J. Wegman, Xiaofeng Hu, Jolanda M.A. Boer, Jacoline B. ten Brink, Aeilko H. Zwinderman, John J.P. Kastelein, Edith J.M. Feskens, Arthur A.B. Bergen
Journal: Circulation (2002)

Background— Pseudoxanthoma elasticum (PXE) is an inborn disorder of the connective tissue with specific skin, ocular, and cardiovascular disease (CVD) manifestations. Recently, we and others have identified mutations in the gene coding for the ABCC6 transporter in PXE patients with ocular and skin involvement. In the Netherlands, as in the rest of Europe, a particular premature truncation variant ABCC6 (R1141X) was found in a large cohort of PXE patients. Given the association between CVD and PXE, we hypothesized that heterozygosity of this ABCC6 mutation could also confer an increased risk for CVD. Methods and Results— To assess the relationship between the frequent R1141X mutation in the ABCC6 gene and the prevalence of premature coronary artery disease (CAD), we conducted a case-control study of 441 patients under the age of 50 years who had definite CAD and 1057 age- and sex-matched population-based controls who were free of coronary disease. Strikingly, the prevalence of the R1141X mutation was 4.2 times higher among patients than among controls (3.2% versus 0.8%; P &lt;0.001). Consequently, among subjects with the R1141X mutation, the odds ratio for a coronary event was 4.23 (95% CI: 1.76 to 10.20, P = 0.001). Conclusion— The presence of the R1141X mutation in the ABCC6 gene is associated with a sharply increased risk of premature CAD.
Diffuse Histiocytic Lymphoma
Authors: BARRY H. KAPLAN
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 December 1982Diffuse Histiocytic LymphomaBARRY H. KAPLAN, M.D.BARRY H. KAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-6-929 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: After the exciting pioneering work on the curability of histiocytic lymphoma conducted at the National Institutes of Health in the mid 1970s, there has been a stream of pilot studies using various treatments for histiocytic lymphoma. The article, "Combination Chemotherapy of Advanced Diffuse Histiocytic Lymphoma With the Six-Drug COP-BLAM Regimen," by Laurence and associates in the August issue (1) is only the latest in this stream.The only conclusions that can be drawn from this small pilot study in a disease like histiocytic lymphoma with a 50% cure rate is that the treatment is tolerable and has...Reference1. LAURENCECOLEMANALLENSILVERPASMANTIER JMSRM. Combination chemotherapy of advanced diffuse histiocytic lymphoma with the six-drug COP-BLAM regimen. Ann Intern Med. 1982;97:190-5. LinkGoogle Scholar1. ULTMANN J. Cure of histiocytic lymphoma. Ann Intern Med. 1982;97:274-5. LinkGoogle Scholar2. DEVITACANELLOSCHABNERSCHEINHUBBARDYOUNG VGBPSR. Advanced diffuse histiocytic lymphoma, a potentially curable disease: results with combination chemotherapy. Lancet. 1975;1:248-50. CrossrefMedlineGoogle Scholar3. SWEETGOLOMBULTMANN DHJ. Cyclophosphamide, vincristine, methotrexate with leukovorin rescue, and cytarabine (COMLA) combination sequential chemotherapy for advanced diffuse histiocytic lymphoma. Ann Intern Med. 1980;92:785-90. LinkGoogle Scholar4. BUNNSCHEINBANKSDEVITA PPPV. Central nervous system complications in patients with diffuse histiocytic and undifferentiated lymphoma: leukemia revisited. Blood. 1976;47:3-10. CrossrefMedlineGoogle Scholar5. LITAMCABANILLASSMITHBODEYFREIREICH JFTGE. Central nervous system relapse in malignant lymphomas: risk factors and implications for prophylaxis. Blood. 1979;54:1249-57. CrossrefMedlineGoogle Scholar6. LEVITTDAWSONROSENTHALMOLONEY LDDW. CNS involvement in the non-Hodgkin's lymphomas. Cancer. 1980;45:545-52. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical Oncology Cancer Center Program Albert Einstein College of Medicine of Yeshiva University Bronx, NY 10461 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1982Volume 97, Issue 6Page: 929-930KeywordsCombination chemotherapyDiffuse large B-cell lymphomaPilot studiesRivers Issue Published: 1 December 1982 PDF DownloadLoading ...
The Need for More Vitamin D
Authors: Robert D. Utiger
Journal: New England Journal of Medicine (1998)

Vitamin D is an essential precursor of 1,25-dihydroxyvitamin D, the steroid hormone required not only for bone development and growth in children and maintenance of bone in adults, but also for the prevention of osteoporosis and fractures in the elderly. Although rickets and osteomalacia — the consequences of severe vitamin D deficiency — have largely disappeared, there is increasing evidence of widespread vitamin D deficiency in old and sick people. The findings by Thomas et al. in this issue of the Journal 1 of low serum 25-hydroxyvitamin D concentrations in 57 percent of 290 patients hospitalized on a medical service indicate . . .
Water immersion versus standard colonoscopy insertion technique: randomized trial shows promise for minimal sedation
Authors: C. Leung, T. Kaltenbach, R. Soetikno, K. Wu, F. Leung, S. Friedland
Journal: Endoscopy (2010)

Water immersion is an alternative colonoscopy technique that may reduce discomfort and facilitate insertion of the instrument. This was a prospective study to compare the success of colonoscopy with minimal sedation using water immersion and conventional air insufflation.A total of 229 patients were randomized to either water immersion or the standard air insertion technique. The primary outcome was success of minimal sedation colonoscopy, which was defined as reaching the cecum without additional sedation, exchange of the adult colonoscope or hands-on assistance for trainees. Patient comfort and satisfaction were also assessed.Successful minimal-sedation colonoscopy was achieved in 51 % of the water immersion group compared with 28 % in the standard air group (OR, 2.66; 95 % CI 1.48 - 4.79; P = 0.0004). Attending physicians had 79 % success with water immersion compared with 47 % with air insufflation (OR, 4.19; 95 % CI 1.5 - 12.17; P = 0.002), whereas trainees had 34 % success with water compared with 16 % using air (OR, 2.75; 95 % CI 1.15 - 6.86; P = 0.01). Using the water method, endoscopists intubated the cecum faster and this was particularly notable for trainees (13.0 +/- 7.5 minutes with water vs. 20.5 +/- 13.9 minutes with air; P = 0.0001). Total procedure time was significantly shorter with water for both experienced and trainee endoscopists ( P < 0.05). Patients reported less intraprocedural pain with water compared with air (4.1 +/- 2.7 vs. 5.3 +/- 2.7; P = 0.001), with a similar level of satisfaction. There was no difference in the neoplasm detection rates between the groups.Colonoscopy insertion using water immersion increases the success rate of minimal sedation colonoscopy. Use of the technique leads to a decrease in discomfort, time to reach the cecum, and the amount of sedative and analgesic used, without compromising patient satisfaction.
Sodium and potassium intake and blood pressure.
Authors: P Burstyn, D Hornall, C Watchorn
Journal: BMJ (1980)

Sodium and potassium intakes were increased in normotensive volunteers to assess the effects on their blood pressures. An approximately threefold increase in sodium intake for eight days had no effect on the blood pressures of seven volunteers, while a two-stage increase in potassium intake, by about 40% for eight days and a further 55% for 14 days, had no effect on the blood pressures of 21 volunteers. Renal electrolyte excretions and the blood pressures of all 28 subjects showed no statistically significant correlations between either sodium or potassium excretion and blood pressure. A weak negative correlation was found between the sodium: potassium ratio and systolic pressure. The small reductions in sodium intake and increases in potassium intake that might be achieved through propaganda and changes in food processing are unlikely to lower mean blood pressure in Western societies.
Abstract LB-112: <i>Ex vivo</i> lung cancer nodule model shows efficacy of nanoparticle delivery
Authors: Dhruva K. Mishra, Haifa Shen, Junhua Mai, Harald C. Ott, Brandi N. Baird, Jonathan M. Kurie, Min P. Kim
Journal: Cancer Research (2012)

Abstract Nanoparticles have the potential of being used for treatment of lung cancer. However, it is difficult to determine how nanoparticles target cancer cells in a poorly vascularized tumor nodule. In our study, we hypothesize that we can develop an ex vivo human lung cancer nodule model with a perfusable vascular bed that can be used to test distribution of nanoparticles. To create this ex vivo human lung cancer nodule model, we isolated the rat heart-lung block from a 6-week-old Sprague-Dawley rat. We then removed the native rat cells from the lung using sodium dodecyl sulfate and Triton-X-100 in a customized decelluarization chamber. We then placed human lung cancer cell lines H460 and H1299 through the trachea of the acellular rat lung scaffold in a bioreactor. After three days of growth in the bioreactor, we placed 700 million nanoparticles into the scaffold through the circulation labeled with fluorescent tags. We performed lobectomy 1 and 3 days following placement of the nanoparticles. We examined the distribution of the nanoparticles in the nodules using hematoxylin and eosin (H&amp;E) stain and confocal microscopy. There were numerous tumor nodules on both lung scaffolds, measuring 2 mm, three days after placement of the cells. One day after placement of the nanoparticles the lobectomy specimen on the H&amp;E showed that the scaffold with H460 cells had features of poorly differentiated non-small cell lung cancer with sheet-like growth of polygonal cells and the scaffold with H1299 cells had features of very poorly differentiated malignant cells. Moreover, most of the nanoparticles were distributed along the vascular structures with paucity of nanoparticles in the center of the tumor nodules. The confocal microscopy showed that in some areas, nanoparticles were found inside the cytoplasm and nucleus of the cells. Three days after the placement of the nanoparticles, the H&amp;E showed increased number of cells in the tumor nodules with uptake of nanoparticles. Given these results, we believe that the ex vivo human lung cancer nodule model can be used to show delivery of nanoparticles in a complex nodule and determine its efficacy. This can aid in determining appropriate dose of nanoparticles, design of nanoparticles and efficiency of delivery of nanoparticles to heterogeneous tumor nodules, which would aid in vivo treatment studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-112. doi:1538-7445.AM2012-LB-112
Designing research in vulnerable populations: lessons from HIV prevention trials that stopped early
Authors: Edward J Mills, Sonal Singh, Jerome A Singh, James J Orbinski, Mitchell Warren, Ross E Upshur
Journal: BMJ (2005)

Activist groups have been successful in promoting research and better treatment for people with HIV infection, but they can also stop trials if their views are not considered 

Methods to prevent HIV infection are one of the most urgent global public health needs.1 One novel method in clinical trials is pre-exposure prophylaxis with the antiretroviral drug tenofovir. The trials have, however, been criticised by activist groups, citing human rights, ethical concerns, and a lack of community involvement.2 This opposition and media coverage has stopped two trials in Cambodia and Cameroon and threatens the stability of planned and recruiting trials among intravenous drug users in Thailand and other developing nations. The issues raised by activists, academics, and the research community highlight the poor communication between these stakeholders and the need for mutual understanding of values. The differences threaten to undermine the progress of prevention trials and ultimately affect the most important stakeholders, those who are at risk.3



This protest at the 2004 International AIDS Society Conference helped stop the Cambodian tenofovir trialCredit: STR/AFP/GETTY IMAGES



### Cambodia

The first randomised trial planned to assess the safety and efficacy of prophylactic tenofovir was in Phnom Penh, Cambodia. The study, funded by the US National Institutes of Health and the Bill and Melinda Gates Foundation, planned to recruit 960 sex workers and was led by researchers from the United States and Australia.3 In July 2004, activists mounted the first large demonstration against the trial at the Gilead booth at the International AIDS Society conference in Bangkok, a protest that captured the world's media attention.4 This protest, as well as local remonstration to the Ministry of Health in Cambodia, resulted in the Cambodian prime minister closing the trial before recruitment.

The government has provided no official reasons for its decision. The primary …