Pulmonary Alveolar Proteinosis
Authors: JOHN JEFFREY NICHOLAS
Journal: Annals of Internal Medicine (1965)

Case Studies1 February 1965Pulmonary Alveolar ProteinosisA Case with Improvement After a Short Course of Endobronchial Instillations of HeparinJOHN JEFFREY NICHOLAS, M.D., J. HOWLAND AUCHINCLOSS JR., M.D., LIONEL RUDOLPH, M.D.JOHN JEFFREY NICHOLAS, M.D.Search for more papers by this author, J. HOWLAND AUCHINCLOSS JR., M.D.Search for more papers by this author, LIONEL RUDOLPH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-358 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1958, Rosen, Castleman, and Liebow (1) first described pulmonary alveolar proteinosis, a disease in which a homogeneous proteinaceous material filled the alveoli and small bronchi. These authors felt that this was a new disease entity because such striking pathological findings could hardly have been overlooked by previous observers.The course of the disease may be interrupted by spontaneous remission (2, 3), but death often occurs. Rosen listed 15 deaths among the 50 cases he had collected by 1960 (4). Other authors have reported 8 additional deaths (5-11). In all, 23 deaths have been reported among the approximately 85 cases...References1. ROSENCASTLEMANLIEBOW SHBA: Pulmonary alveolar proteinosis. New Eng. J. Med. 258: 1123, 1958. CrossrefMedlineGoogle Scholar2. DICKRYANKUTZERDELMONACOPRIOR HJYMJEPA: Pneumocystis carinii infection in New York State: Preliminary report. Proc. NY Public Health Lab. 37: 3, 1957. Google Scholar3. PHILLIPSCONSTANCE JEJJ: Pulmonary alveolar proteinosis. Med. J. Aust. 2: 357, 1963. CrossrefMedlineGoogle Scholar4. ROSEN SH: Pulmonary alveolar proteinosis. U. S. Armed Forces Med. J. 11: 1507, 1960. MedlineGoogle Scholar5. ANDRIOLEBALLASWILSON VTMGL: The association of nocardiosis and pulmonary alveolar proteinosis. Ann. Intern. Med. 60: 266, 1964. LinkGoogle Scholar6. CARLSONHILLROWLANDS ETRBDT: Nocardiosis and pulmonary alveolar proteinosis. Ibid., p. 275. Google Scholar7. TALEGHANI-FARBARBERSAMPSONHARDIN MJBCKA: Cerebral nocardiosis and pulmonary alveolar proteinosis. Amer. Rev. Resp. Dis. 89: 561, 1964. MedlineGoogle Scholar8. BIANCOTOMATIS SL: Pulmonary alveolar proteinosis: a case report. Pathologica 52: 85, 1960. MedlineGoogle Scholar9. HARRISONDIVERTIEOLSEN EGMBAM: Pulmonary alveolar proteinosis: report of a case with fatal outcome. JAMA 173: 327, 1960. CrossrefMedlineGoogle Scholar10. JONES CC: Pulmonary alveolar proteinosis with unusual complicating infections. Amer. J. Med. 29: 713, 1960. CrossrefMedlineGoogle Scholar11. PLENCKSWIFTCHAMBERSPELTZER HPSAWLWE: Pulmonary alveolar proteinosis: a new disease? Radiology 74: 928, 1960. CrossrefMedlineGoogle Scholar12. SIERACKIHORNKAY JCRCS: Pulmonary alveolar proteinosis: report of three cases. Ann. Intern. Med. 51: 728, 1959. LinkGoogle Scholar13. SANDERSKAHANBAR MMS: Pulmonary alveolar proteinosis. A review of the literature. Dis. Chest 42: 437, 1962. CrossrefMedlineGoogle Scholar14. LOVETTEMAGOVERNKENT JBGJEM: Alveolar proteinosis. Arch. Intern. Med. (Chicago) 108: 611, 1961. CrossrefMedlineGoogle Scholar15. PAYSEURKONWALERHYDE CRBEL: Pulmonary alveolar proteinosis: a progressive diffuse fatal pulmonary disease. Amer. Rev. Tuberculosis 78: 906, 1958. MedlineGoogle Scholar16. UDANIMUKERJU PMS: Pulmonary alveolar proteinosis. Indian J. Child Health 12: 256, 1963. MedlineGoogle Scholar17. WILLIAMSMEDLEYBROWN GEDRR: Pulmonary alveolar proteinosis. Lancet 1: 1385, 1960. CrossrefMedlineGoogle Scholar18. MOERTELWOOLNERBERNATZ CGLBPE: Pulmonary alveolar proteinosis. Proc. Mayo Clin. 34: 152, 1959. MedlineGoogle Scholar19. HALL GJ: Pulmonary alveolar proteinosis. Lancet 1: 1383, 1960. CrossrefMedlineGoogle Scholar20. BRODSKYMAYCOCK IRL: Pulmonary alveolar proteinosis. Remission after therapy with trypsin and chymotrypsin. New Eng. J. Med. 265: 935, 1961. CrossrefMedlineGoogle Scholar21. CARABASIBARTA RJLL: Atypical pneumonitis with interstitial fibrosis, an unusual case receiving prolonged corticosteroid therapy. Dis. Chest 36: 209, 1959. CrossrefMedlineGoogle Scholar22. FRAIMOWCATHCARTKIRSHNERTAYLOR WRTJJRC: Pulmonary alveolar proteinosis: a correlation of pathological and physiological findings in a patient followed by serial biopsies of the lung. Ann. Intern. Med. 52: 1177, 1960. LinkGoogle Scholar23. KNOTTMACHAFFIELINLOOMISBRODY JLRATKGWAW: Pulmonary alveolar proteinosis: a case with cardiac catheterization and pulmonary function studies. Ann. Intern. Med. 55: 481, 1961. LinkGoogle Scholar24. MAHAFFYRUSHALLEN DEENJD: Pulmonary alveolar proteinosis treated with Varidase. J. Kentucky Med. Ass. 57: 1230, 1959. MedlineGoogle Scholar25. SLUTZKERPERRYMAN BPH: Pulmonary alveolar proteinosis: response to nebulized enzyme therapy. Arch. Intern, Med. (Chicago) 109: 406, 1962. CrossrefMedlineGoogle Scholar26. MCDOWELLWILLIAMSHINDS CSEJR: Pulmonary alveolar proteinosis: report of a case. Aust. Ann. Med. 8: 137, 1959. MedlineGoogle Scholar27. RAMIREZ-RNYKAMCLAUGHLIN JWJ: Pulmonary alveolar proteinosis: diagnostic techniques and observations. New Eng. J. Med. 268: 165, 1963. CrossrefMedlineGoogle Scholar28. RAMIREZ-RSCHULTZDUTTON JRBRE: Pulmonary alveolar proteinosis: a new technique and rational for treatment. Arch. Intern. Med. (Chicago) 112: 419, 1963. CrossrefMedlineGoogle Scholar29. MCLAUGHLINRAMIREZ-R JSJ: Pulmonary alveolar proteinosis: treatment by pulmonary segmental flooding. Amer. Rev. Resp. Dis. 89: 745, 1964. MedlineGoogle Scholar30. BRODSKY I: Letter to the editor. New Eng. J. Med. 268: 1088, 1963. Google Scholar31. OGILVIEFORSTERBLACKEMOREMORTON CMREWSJW: A standardized breath holding technique for the clinical measurement of the diffusing capacity of the lung for carbon monoxide. J. Clin. Invest. 36: 1, 1957. CrossrefMedlineGoogle Scholar32. AUCHINCLOSSGILBERTEICH JHRRH: The pulmonary diffusing capacity in congenital and rheumatic heart disease. Circulation 19: 232 1959. CrossrefMedlineGoogle Scholar33. ANDERSONENGEL OSK: An improved method for the calculation of the relevant blood acid-base data. Scand. J. Clin. Lab. Invest. 12: 177, 1960. CrossrefMedlineGoogle Scholar34. PATTLETHOMAS RELC: Lipoprotein composition of the film lining the lung. Nature (London) 189: 844, 1961. CrossrefMedlineGoogle Scholar35. LOSOWSKYJONESDAVIDSONLIEBER MSDPCSCS: Studies of alcoholic hyperlipemia and its mechanism. Amer. J. Med. 35: 794, 1963. CrossrefMedlineGoogle Scholar36. MARIN A: On the lipase activity of the lung in pathological conditions: IV. Histopathological study and significance of the enzyme behavior. Riv. Anat. Pat. Oncol. 18: 473, 1960. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Syracuse, New YorkFrom the Department of Medicine, State University of New York, Upstate Medical Center, Syracuse, N. Y.This study was supported by a grant from the Hendricks Fund and by grants H-2800 and PN-2014 from the United States Public Health Service, Bethesda, Md.Requests for reprints should be addressed to John Jeffrey Nicholas, M. D., Department of Medicine, Upstate Medical Center, Syracuse, N. Y. 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LADMAN, PH.D.Beitrag zur Alveolarproteinose der LungenMikrolithiasis, Amyloidose und Proteinose der Lungen 1 February 1965Volume 62, Issue 2Page: 358-366KeywordsAlveoliCathetersDyspneaGas analysisHypertensionMedical servicesProteinsPulmonary diseasesSteroid therapyTrachea Issue Published: 1 February 1965 PDF downloadLoading ...