tbuckley/cabot-search huggingface dataset:
Propranolol induced lipid accumulation and mitochondrial granularity in myocardial cells
Authors: S. ROTEVATN, H. G JODALEN, R. K LIE
Journal: Cardiovascular Research (1983)

The ultrastructure of the left ventricular wall was studied in mice given intraperitoneal injections of propranolol (5 mg or 20 mg·kg−1 b.w. twice a day for 48 h with an additional dose 3 h before death), and in saline injected controls. Injections of propranolol increase the number of lipid droplets in areas of the myocardium. Fractional volume of lipid droplets in myocardial cells determined using quantitative stereological techniques, showed an increase of 280% and 544% in the group receiving the lowest and highest doses respectively. Injections of propranolol were also followed by an increased granularity of the mitochondria.
Abstract A60: Foxf1 transcription factor drives progression of benign lung adenomas to malignant adenocarcinomas
Authors: Xinjian Wang, David Balli, Tien Le, Vladimir V. Kalinichenko, Tatiana V. Kalin
Journal: Cancer Research (2013)

Abstract Lung cancer is the leading cause of cancer-related deaths in the United States with current 5-year survival only 8—12%. Patients with non-small cell lung cancer (NSCLC) develop metastases prior to clinical symptoms, which reduces successful treatment outcomes. The new therapeutic approaches targeting progression and metastasis of NSCLC are needed. Foxf1 transcription factor is expressed in mesenhyme-derived cells, such as fibroblasts, smooth muscle cells and endothelial cells, but absent from epithelial-derived cells, such as alveolar and airway epithelial cells, and benign lung adenoma cells. In present study, we used immunohistochemistry to demonstrate that Foxf1 expression is up-regulated in the invasive front of human lung adenocarcinomas. Foxf1 expression is also induced in mouse lung adenocarcinomas, caused by either activation of K-Ras G12D transgene or transplantation of Lewis Lung Carcinoma (LLC) cells. In vitro, shRNA-mediated depletion of Foxf1 from LLC cells decreased migration, invasion and colony formation of LLC cells on soft agar. Depletion of Foxf1 reduced mRNA and protein levels of Twist1, and prevented TGFbeta-induced EMT. In vivo, Foxf1-depleted LLC cells failed to form lung metastasis in the transplantation model of lung cancer. Furthermore, we generated transgenic mice with Doxycycline-inducible expression of Foxf1 under control of epithelial-specific SPC-promoter (epFoxf1 mice). Lung adenomas in these mice were induced by urethane. Activation of the Foxf1 transgene in pre-existing lung adenomas promoted their progression towards adenocarcinomas that invaded adjacent bronchiolar lumens and pleural surfaces. Transgenic expression of Foxf1 in tumor cells resulted in the loss of cell polarity, decreased E-cadherin, and increased expression of aSMA, Twist1 and other EMT associated genes. Foxf1 directly bound to promoter region of Twist1, implicating the Foxf1 in the regulation of the Twist1 gene. The present study provides the first genetic evidence that aberrant expression of Foxf1 induces EMT in lung tumors and promotes the progression of lung adenomas to invasive adenocarcinomas, suggesting that Foxf1 is a promising target for anti-cancer therapy. Citation Format: Xinjian Wang, David Balli, Tien Le, Vladimir V. Kalinichenko, Tatiana V. Kalin. Foxf1 transcription factor drives progression of benign lung adenomas to malignant adenocarcinomas. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A60.
A fluorescence photographic photometric technique to assess stratum corneum turnover rate and barrier function in vivo
Authors: A.Y. Finlay, R.J. Marshall, R. Marks
Journal: British Journal of Dermatology (1982)

A photographic photometric method for objective measurement of fluorescence in skin is described. This method has been used to (a) improve the dansyl chloride method for determining stratum corneum turnover time by making assessments objective and quantitative, and (b) examine the barrier function of the stratum corneum by measuring the concentration of a fluorescent material at different levels within the stratum corneum at different times.
David Hugh McCollum
Authors: Charles N McCollum
Journal: BMJ (2004)

​FormerFormer general practitioner Penkridge, Staffordshire (b 1917; q Belfast, 1940; MC), d 12 May 2004.




Figure 1




After qualifying David McCollum enlisted in the Royal Army Medical Corps. He was responsible for the triage and evacuation of casualties from the Anzio beachhead. David was responsible for the care of both Allied and German wounded alike, but always claimed that he was awarded his Military Cross for dispensing tea with high brandy content to the general. After a spell in the Royal Maternity Hospital in Belfast and a short time in Leicester as an assistant in general practice, he moved to be a partner in Penkridge, Staffordshire, where he then became singlehanded for 15 years. He leaves a wife, Jean; four sons; and seven grandchildren.
84 Direct interaction of rat ileal NA + dependent bile acid transporter with a 16 KDA subunit C of vacuolar H + ATPase
Authors: N BALASUBRAMANIYAN, C LIU, M SHAHID, F SUCHY, A SUN
Journal: Hepatology (2003)

Celiprolol is a novel β-adrenoceptor blocking drug that displays clinically favorable effects on glucose and lipid metabolism. Because some other atypical β-adrenoceptor blocking drugs have been described to act as agonists on β3-adrenoceptors, we aimed to investigate the effects of celiprolol on brown fat and β3-adrenoceptors. Chronic treatment of obese fa/fa Zucker rats with celiprolol (50 mg/kg/day orally for 20 days) increased GDP binding to brown fat mitochondria by 1.5-fold, whereas β3-adrenoceptor agonist ZD7114 ((S)-4-[2-[(2-hydroxy-3-phenoxypropyl)amino]ethoxy]-N-(2-methoxyethyl)phenoxyacetamide, 3 mg/kg/day) increased the binding by 3.3-fold. Weight gain was reduced by 19% due to decreased water and food intakes in celiprolol-treated rats. Celiprolol did not activate lipolysis in rat adipocytes in vitro or stimulate human β3-adrenoceptors expressed in Chinese hamster ovary cells as measured with Cytosensor microphysiometer. Therefore, celiprolol does not seem to activate brown fat via β3-adrenoceptors.
Peter Arbuthnot Watt
Authors: M. Cullen
Journal: BMJ (2012)

Peter Arbuthnot Watt was the son and grandson of Tavistock general practitioners and so was steeped in the culture of west Devon from birth. After two years as houseman and then accoucheur at the London Hospital he served as a captain in the Royal Army Medical Corps (RAMC) in Germany and then at the British Military Hospital, Hong Kong.

After returning to the UK in 1956 he held posts as a medical registrar. At interview for a registrars post in Bath he discovered his conviction of the importance of general practice and …
Cardiac tamponade as an initial manifestation of systemic lupus erythematosus in early childhood.
Authors: S Gulati, L Kumar
Journal: Annals of the Rheumatic Diseases (1992)

Cardiac tamponade is rare as an initial manifestation of systemic lupus erythematosus (SLE), and even more so in paediatric patients. This paper reports an 8 year old girl with SLE with several unusual features: unusual age of presentation, unusual initial organ manifestation and recurrent cardiac tamponade as a complication.
Abstract 17950: Prediction of Sudden Cardiac Death in Chronic Heart Failure Patients with Mild to Moderate Systolic Dysfunction a Prospective Comparative Study of Cardiac I-123 Metaiodobenzylguanidine Imaging and Heart Rate Turbulence
Authors: Tadao Fujimoto, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Yoshio Furukawa, Koji Tanaka, Yusuke Iwasaki, Kawasaki Masatake, Yuki Kuramoto, Takashi Naito, Kentaro Ozu, Takumi Kondou, Kaoruko Sengoku, Hironori Yamamoto
Journal: Circulation (2011)

Background: Although it is shown that ICD therapy could prevent sudden cardiac death (SCD) in chronic heart failure (CHF) patients with severely reduced LV systolic function (LV ejection fraction &lt;35%), it remains unclear which CHF patients with LVEF&gt;35% would have the risk of SCD. Therefore, we sought to prospectively compare the prognostic values for SCD of cardiac metaiodobenzylguanidine (MIBG) imaging and heart rate turbulence (HRT) analysis ,which are expected to provide prognostic information , in CHF patients with LVEF&gt;35% in the gray zone for the ICD therapy. Methods and Results: We enrolled 55 CHF outpatients (NYHA 2±0.2) with radionuclide LV ejection fraction from 35% to 50% (38.5±0.8%). We performed the cardiac MIBG imaging and 24-hour Holter monitoring at the entry. The cardiac MIBG wash out rate (WR) was calculated from the chest anterior view images obtained at 20 and 200 min after isotope injection. Abnormal WR was defined as WR &gt;27%. Furthermore, we also performed HRT analysis from Holter monitoring. Turbulance onset (TO) and turbulence slope (TS) were calculated as HRT parameters. Abnormal values of HRT analysis were defined as TO≥0% and TS≤2.5ms/beat. Result: During the follow up period of 6.0±0.8 years, 7 of 55 patients had SCD. At multivariate Cox analysis, WR was significantly (p=0.015) and independently associated with SCD, while TO and TS had no association with SCD. SCD was significantly more frequently observed in patients with than without abnormal WR (30% vs 3%, p=0.002), although there was no significant difference in the incidence of SCD between patients with and without abnormal HRT results. The hazard ratio of abnormal WR for SCD was 13 .7( 95%CI 1.6 to 114.7). Conclusion: Cardiac MIBG imaging, but not HRT analysis, would be useful to predict the risk of sudden cardiac death in CHF patients with mildly to moderately reduced LV systolic function.
Going in circles: conserved mechanisms control radial patterning in the urinary and digestive tracts
Authors: C. Mendelsohn
Journal: Journal of Clinical Investigation (2006)

Radial patterning in the urinary tract and gut depends on reciprocal signaling between epithelial cells, which form mucosa, and mesenchyme, which forms smooth muscle and connective tissue. These interactions depend on sonic hedgehog (Shh), which is secreted by epithelial cells and induces expression of bone morphogenetic protein 4 (Bmp4), a signaling molecule required for differentiation of smooth muscle progenitors. Patterning of the specialized mucosa lining the anterior-posterior (A-P) axis may be controlled independently by regionally expressed mesenchymal transcription factors. A study by Airik et al. in this issue of the JCI reveals that T-box 18 (Tbx18), a transcription factor selectively expressed in ureteral mesenchyme, regulates smooth muscle differentiation by maintaining Shh1 responsiveness in mesenchymal progenitors. Deletion of Tbx18 resulted in defective urothelial differentiation at the level of the ureter, suggesting that Tbx18 acts via mesenchyme as an important regulator of A-P patterning in the urinary tract.
Hemotherapy of the Infant and Premature
Authors: Ruth Andrea Seeler
Journal: JAMA (1986)

This handy monograph from the American Association of Blood Banks presents a state-of-the-art summary of transfusional problems and therapy in the premature and full-term neonate. Although the outgrowth of an American Association of Blood Banks technical workshop, the monograph deserves a much broader pediatric audience, especially among house staff, students, and neonatology fellows who all too frequently do not consider transfusion therapy the science that it is. Approximately half of the monograph is written by expert pediatricians who are involved in direct patient care. The initial chapter provides useful tables of normal values, which change so rapidly during this critical period of life. The unique interactive physiology and pathophysiology of the neonate and of fetal hemoglobin and the erythrocyte are concisely reviewed. Then follows a discussion of the indications for erythrocyte transfusion and a review of the metabolic considerations of anticoagulants, storage, and effects in transfusion into the sick or
The Roentgenographic Diagnosis of Renal Mass Lesions
Authors: Yolanda Adler
Journal: JAMA (1971)

This book centers on the topics of renal tumor, renal cysts, and the coexistence of renal cysts and carcinoma. These subjects are treated in detail and with expertise, with presentation of numerous cases showing both usual and unusual manifestations. Cyst puncture and opacification are discussed extensively. At the end of the book is a short chapter on technique, dealing mainly with criteria for obtaining different views or, in the case of arteriography, for making different selective studies. There are many illustrations of interesting representative cases, but we could wish that the plates depicting different phases of a particular case would have been grouped in opposite pages to avoid the need for continuous turning back and forth to follow a case through. The title is somewhat misleading. Although the book is supposed to deal with renal masses, only tumors or cysts are studied in detail. Very little mention is made of
Dust and airborne exposure to allergens derived from cockroach (Blattella germanica) in low-cost public housing in Strasbourg (France)
Authors: Frédéric de Blay, José Sanchez, Guy Hedelin, Antonio Perez-Infante, Angèle Vérot, Martin Chapman, Gabrielle Pauli
Journal: Journal of Allergy and Clinical Immunology (1997)
Quantitative elastography associated with endoscopic ultrasound for the diagnosis of chronic pancreatitis
Authors: Julio Iglesias-Garcia, J. Domínguez-Muñoz, Marga Castiñeira-Alvariño, Maria Luaces-Regueira, Jose Lariño-Noia
Journal: Endoscopy (2013)

<b>Background and study aims:</b> Endoscopic ultrasonography (EUS) has become the method of choice for the diagnosis of chronic pancreatitis in clinical practice. However, the criteria allowing the specific diagnosis of the disease, mainly at non-advanced stages, are still under debate. Analysis of tissue stiffness by quantitative EUS–elastography may provide additional relevant information in this setting. The aim of this study was to evaluate the information provided by quantitative EUS–elastography for the diagnosis of chronic pancreatitis. <b>Patients and methods:</b> A prospective, consecutive, 1-year study was designed, and included patients who underwent EUS for epigastric pain syndrome or known chronic pancreatitis. EUS–elastography was performed using radial Pentax EUS and Hitachi EUB900. The strain ratio was measured in the head, body, and tail of the pancreas, and the elastographic result was the mean of these three values. EUS criteria of chronic pancreatitis and the Rosemont classification were also evaluated. Data were analyzed by analysis of variance and linear regression; diagnostic accuracy was based on the receiver operating characteristic (ROC) curve analysis. <b>Results:</b> A total of 191 patients (mean age 52 years, range 21 – 85; 103 male) were included; 92 (48.2 %) of them were finally diagnosed with chronic pancreatitis. A highly significant direct linear correlation was found between the number of EUS criteria of chronic pancreatitis and the strain ratio (r = 0.813; <i>P</i> < 0.0001). The area under the ROC curve was 0.949 (95 % confidence interval 0.916 – 0.982) and the accuracy of EUS–elastography for diagnosing chronic pancreatitis was 91.1 % (cut-off strain ratio of 2.25). The strain ratio varied significantly in different Rosemont classification groups (<i>P</i> < 0.001). <b>Conclusions:</b> EUS–elastography was an accurate tool for the diagnosis of chronic pancreatitis and provided relevant and objective information to support EUS findings.
The Letter or the Spirit Consent for Research in CPR
Authors: Carin M. Olson
Journal: JAMA (1994)

Major scientific advances may begin serendipitously. The idea for active compression-decompression cardiopulmonary resuscitation (ACD CPR) came from an anecdotal account of successful resuscitation using a toilet plunger.1Subsequent research supported the concept, as better cardiovascular hemodynamics among animals2,3or humans4-7or better short-term survival among humans8,9was found with ACD CPR compared with standard CPR. One study even suggested that ACD CPR might improve neurological outcomes, as pigs receiving ACD CPR had better cerebral hemodynamics, oxygenation, and metabolism.10  This issue ofThe Journaldescribes a study11of ACD CPR that was terminated by the US Food and Drug Administration (FDA) before completion, primarily because of concerns about informed consent. The project was funded by Ambu International, the maker of the Ambu CardioPump ACD CPR device; there was no federal support. The protocol had been approved by the institutional review board (IRB) of the St
Activation of Inflammation and Coagulation After Infusion of C-Reactive Protein in Humans
Authors: Radjesh J. Bisoendial, John J.P. Kastelein, Johannes H.M. Levels, Jaap J. Zwaginga, Bas van den Bogaard, Pieter H. Reitsma, Joost C.M. Meijers, Daniel Hartman, Marcel Levi, Erik S.G. Stroes
Journal: Circulation Research (2005)

C-reactive protein (CRP) has been postulated to play a causal part in atherosclerosis and its acute complications. We assessed the effects of CRP-infusion on coagulation and inflammatory pathways to determine its role in atherothrombotic disease. Seven male volunteers received an infusion on two occasions, containing 1.25 mg/kg recombinant human CRP (rhCRP) or diluent, respectively. CRP-concentrations rose after rhCRP-infusion from 1.9 (0.3 to 8.5) to 23.9 (20.5 to 28.1) mg/L, and subsequently both inflammation and coagulation were activated. This sequence of events suggests that CRP is not only a well known marker of cardiovascular disease, but is also probably a mediator of atherothrombotic disease.
The doctor, the patient, and their contract. III. Alternative contracts: are they viable?
Authors: A Maynard, M Marinker, D P Gray
Journal: BMJ (1986)

When change is proposed there are always alternative courses of action and any choice between these alternatives needs to take account of their relative advantages and disadvantages.In our first paper (17 May, p 1313) we examined the reasons for changing from the status quo.Here we examine five further options.The first is to return to a form of remuneration for general practitioners that is determined solely by capitation payments.The second is to rely on payments per items of service.The third is to choose a salaried service.The fourth is to rely on private practice, allowing market forces to determine both quality and rewards.The fifth is to move to a form of national health service that is funded, as it is now, out of taxation but combining entrepreneurial and competitive elements with the profession controlling the standards.We conclude that the development of a good practice allowance, along the lines described in our previous paper (24 May, p 1374), represents the best choice at this time for the public, the government, and the profession. CapitationRoughly 45% of the income of general practitioners is derived from capitation.In the government's discussion document Primary Health Care the possibility is raised of increasing the proportion, not only in recognition of the link between workload and list size but also to motivate doctors to practise in a way that would encourage patients to join their list.'At the beginning ofthe National Health Service the income ofpractitioners was almost entirely derived from capitation, and this system persisted until the reforms of the mid-1960s.The major theoretical advantage of a pure capitation system of payment is that the doctor becomes much more consumer oriented.The level of his income is directly linked to the number of patients whom he can attract.This should strongly motivate him to provide good premises, courteous staff, rapid accessibility, and informative practice brochures.There are, however, several theoretical disadvantages to an unbridled capitation system.There is no direct means of using the system to pursue public police in health care.The consumer's standards may be met, but professional standards of health care may be ignored.The system might
TCT-81 Doppler-flow and pressure derived hyperemic microvascular resistance measurements predict abnormal H 2 15 O PET-quantified myocardial blood flow after primary PCI
Authors: Guus d Waard, Paul F. Teunissen, Ibrahim Danad, Lourens F. Robbers, Maurits Hollander, Aernout M. Beek, Albert C. van Rossum, Paul Knaapen, Niels van Royen
Journal: Journal of the American College of Cardiology (2013)
Family Studies of Respiratory Infections
Authors: F. S. W. Brimblecombe, R. Cruickshank, P. L. Masters, D. D. Reid, G. T. Stewart
Journal: BMJ (1958)

Surveys of morbidity in countries with temperate climates have established the pre-eminent importance of acute respiratory infections as a cause of sickness at all ages.The more severe forms take a heavy toll of life among the very young and the elderly, and, particularly in infancy and early childhood, the mortality from bron- chitis and pneumonia has a strong association with social conditions.The Payling Wrights (1945), in their study of, aetiological factors in bronchopneumonia among children under 2 years of age in London, found a strong correlation between mortality and substandard housing, social index, and the percentage below the poverty line.
Six Cases of Inherited Deficiency of Serum Alpha_1 Antitrypsin Associated with Premature Pulmonary Emphysema.
Authors: John D. Allen
Journal: Annals of Internal Medicine (1967)

s1 May 1967Six Cases of Inherited Deficiency of Serum Alpha1 Antitrypsin Associated with Premature Pulmonary Emphysema.John D. Allen, M.D.John D. Allen, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1054_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany humoral and mechanical factors have been implicated during the past 3 decades in the development of acquired emphysema. However, it has only been in recent years that Eriksson in Sweden has demonstrated that hereditary factors in the form of a serum deficiency of alpha-1 globulin and antitrypsin are associated with the development of obstructive pulmonary disease at an early age in adults. That this problem is not frequently recognized seems apparent since only two previous case reports have appeared in this country.We have had the opportunity to see and follow the five patients presented in this report during... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1054-1055KeywordsEmphysemaGlobulinsPulmonary diseases Issue Published: 1 May 1967 PDF DownloadLoading ...