Metabolic Effects of Dietary Protein in Chronic Renal Failure
Authors: DANIEL M. LEVIN
Journal: Annals of Internal Medicine (1965)

Article1 October 1965Metabolic Effects of Dietary Protein in Chronic Renal FailureDANIEL M. LEVIN, M.D., ROBERT CADE, M.D.DANIEL M. LEVIN, M.D.Search for more papers by this author, ROBERT CADE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-4-642 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the time of Richard Bright, protein restriction has been widely advocated in the treatment of chronic renal failure (1-7). Evidence, however, that such dietary management actually improves renal function in azotemia is scarce.On the contrary, much animal data has accumulated to indicate that renal function varies directly with protein intake; that is, the greater the dietary protein, the better the filtering ability of the kidney. Glomerular filtration rate (GFR), as measured by urea clearance, has been found to rise 100% after a meat meal in a normal dog that had previously been on a low protein diet (8);...References1. FARRSMADEL LEJE: The effect of dietary protein on the course of nephrotoxic nephritis in rats. J. Exp. Med. 70: 615, 1939. CrossrefMedlineGoogle Scholar2. MASSONCORCORANPAGE GACIH: Dietary and hormonal influences in experimental uremia. J. Lab. Clin. Med. 34: 925, 1949. MedlineGoogle Scholar3. KEMPNER W: Compensation of renal metabolic dysfunction. N. Carolina Med. J. 6: 62, 1945. Google Scholar4. THORN GW: Physiologic considerations in the treatment of nephritis. New Eng. J. Med. 229: 33, 1943. CrossrefGoogle Scholar5. ADDIS T: Glomerular Nephritis. The MacMillan Company, New York, 1952, p. 262. Google Scholar6. BORST JG: Protein katabolism in uraemia. Lancet 1: 824, 1948. CrossrefMedlineGoogle Scholar7. KOLFF WJ: Forced high caloric, low protein diet and the treatment of uremia. Amer. J. 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WOLTHIUS FH: Balance studies on protein metabolism in normal and uraemic men. Acta Med. Scand. 171, supp. 373: 1, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL M. LEVIN, M.D.; ROBERT CADE, M.D.Affiliations: Gainesville, FloridaFrom the Department of Medicine, University of Florida College of Medicine, Gainesville, Fla.This work was supported by grants from the Florida Heart Association, the Suncoast Heart Association, and grants NIH-FR-82, NIH-AM-05712 from the National Institutes of Arthritis and Metabolic Diseases and NIH-GM-8792 from the Research Career Program Coordinating Section. U. S. Public Health Service, Bethesda, Md.This study was completed while Dr. Levin was supported by the Clinical Investigator program of the Veterans Administration.Requests for reprints should be addressed to Daniel M. Levin, M.D., Instructor, Department of Medicine, The J. Hillis Miller Health Center, University of Florida, Gainesville, Fla. 32603. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetic Nephropathy: New Directions in ManagementCan the Rate of Progression of Chronic Renal Failure Be Altered?Progression of chronic renal failure in manReversing glomerular hypertension stabilizes established glomerular injuryEffect of an acute protein load on the creatinine clearance in healthy vegetariansCan Low-Protein Diet Retard the Progression of Chronic Renal Failure?PROSPECTIVE RANDOMISED TRIAL OF EARLY DIETARY PROTEIN RESTRICTION IN CHRONIC RENAL FAILUREInfluence of Nutritional Therapy on Progression of Renal InsufficiencyCan low protein diet retard the progression of chronic renal failure?Dynamics of Diet TherapyConservative Management of Chronic Renal Failure 1 October 1965Volume 63, Issue 4Page: 642-653KeywordsBlood plasmaCareers in researchExcretionHeart diseasesMetabolic disordersPlasma proteinsProteinsRenal failureResearch laboratoriesUrea ePublished: 1 December 2008 Issue Published: 1 October 1965 PDF downloadLoading ...