Platelet Kinetics in Autoimmune Thrombocytopenia: Relation Between Splenic Platelet Sequestration and Response to Splenectomy
Authors: CURT A. RIES
Journal: Annals of Internal Medicine (1977)

Letters1 February 1977Platelet Kinetics in Autoimmune Thrombocytopenia: Relation Between Splenic Platelet Sequestration and Response to SplenectomyCURT A. RIES, M.D.CURT A. RIES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-2-194 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe usefulness of51Cr platelet survival and sequestration studies in predicting response to splenectomy in idiopathic thrombocytopenic purpura and other autoimmune thrombocytopenias remains controversial (1). In one large series of patients with idiopathic thrombocytopenic purpura who had platelet kinetic studies before splenectomy, 81% of patients with splenic sequestration had complete remissions, whereas only 38% of those with splenic and hepatic or "diffuse" sequestration, and 9% of those with hepatic sequestration, had complete remissions (2). Other investigators have reported less consistent results in smaller numbers of patients (3, 4). We found a 93% complete remission rate among 15 patients with idiopathic...References1. WINTROBE M: Clinical Hematology, 7th ed. Philadelphia, Lea & Febiger, 1974, p. 1087 Google Scholar2. NAJEANARDAILLOU YN: The sequestration site of platelets in idiopathic thrombocytopenic purpura: its correlation with the results of splenectomy. Br J Haematol 21:153-164, 1971 CrossrefMedlineGoogle Scholar3. BALDINI M: Idiopathic thrombocytopenic purpura. N Engl J Med 274:1245-1251, 1301-1306, 1360-1367, 1966 CrossrefMedlineGoogle Scholar4. ASTERKEENE RW: Sites of platelet destruction in idiopathic thrombocytopenic purpura. Br J Haematol 16:61-73, 1969 CrossrefMedlineGoogle Scholar5. RIESPRICE CD: (51Cr) Platelet kinetics in thrombocytopenia: correlation between splenic sequestration of platelets and response to splenectomy. Ann Intern Med 80:702-707, 1974 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of California School of Medicine San Francisco, CA 94143 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDoes the site of platelet sequestration predict the response to splenectomy in adult patients with immune thrombocytopenic purpura?Autologous 111In-labelled platelet sequestration studies in patients with primary immune thrombocytopenia (ITP) prior to splenectomy: a report from the United Kingdom ITP RegistrySplenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complicationsScintigraphic prediction of therapeutic outcomes of splenectomy in patients with thrombocytopeniaNormalized spleen/liver ratios on 111In-labelled platelet scintigraphy to predict the outcome of partial splenic embolization in patients with idiopathic thrombocytopenic purpuraLabeled Platelets in Idiopathic Thrombocytopenic PurpuraSize of spleen rather than amount of platelet sequestration may determine long term responses to splenectomy in adult idiopathic thrombocytopenic purpura.Idiopathic Thrombocytopenic PurpuraChronic Idiopathic Thrombocytopenic Purpura (ITP): Site of Platelet Sequestration and Results of SplenectomyBlutungsübel als Indikationen und Kontraindikationen chirurgischer EingriffeAcute idiopathic thrombocytopenic purpura in childrenCase 39-1978 1 February 1977Volume 86, Issue 2Page: 194-195KeywordsIdiopathic thrombocytopenic purpuraPlateletsSplenectomy Issue Published: 1 February 1977 PDF downloadLoading ...