tbuckley/cabot-search huggingface dataset:
Prolonged PR intervals were associated with increased risk for atrial fibrillation, pacemaker implantation, and mortality
Authors: Munther K. Homoud
Journal: Annals of Internal Medicine (2009)

ACP Journal Club17 November 2009Prolonged PR intervals were associated with increased risk for atrial fibrillation, pacemaker implantation, and mortalityMunther K. Homoud, MD, FACP, FACC, FHRSMunther K. Homoud, MD, FACP, FACC, FHRSTufts Medical Center, Boston, Massachusetts, USA (M.K.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-10-200911170-02013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationCheng S, Keyes MJ, Larson MG, et al. Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. JAMA. 2009;301:2571-7. https://pubmed.ncbi.nlm.nih.gov/19549974Clinical Impact RatingsCardiology: References1 Packard JM, Graettinger JS, Graybiel A. Analysis of the electrocardiograms obtained from 1000 young healthy aviators: ten year follow-up. Circulation. 1954;10:384-400. [PMID: 13190611] Google Scholar2 Schnittger I, Appleton CP, Hatle LK, Popp RL. Diastolic mitral and tricuspid regurgitation by Doppler echocardiography in patients with atrioventricular block: new insight into the mechanism of atrioventricular valve closure. J Am Coll Cardiol. 1988;11:83-8. [PMID: 3335709] Google Scholar3 Josephson ME. Atrioventricular conduction. In: Josephson ME. Clinical Cardiac Electrophysiology: Techniques and Interpretations. 4th ed. Philadelphia: Lippincott Williams and Wilkins; 2008:93-113. Google Scholar4 Agarwal YK, Aronow WS, Levy JA, Spodick DH. Association of interatrial block with development of atrial fibrillation. Am J Cardiol. 2003;91:882. [PMID: 12667579] Google Scholar Author, Article, and Disclosure InformationAffiliations: Tufts Medical Center, Boston, Massachusetts, USA (M.K.H.)This article was published at Annals.org on 3 November 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAntidiabetic activity of mefloquine via GLP-1 receptor modulation against STZ–NA-induced diabetes in albino wistar ratsCardioprotection by 6-gingerol in diabetic ratsElectrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat 17 November 2009Volume 151, Issue 10Page: JC5-13KeywordsAtrial fibrillationCardiovascular diseasesHeart rateHypertensionMyocardial infarction ePublished: 17 November 2009 Issue Published: 17 November 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Pernicious Anemia and the Development of Carcinoid Tumors of the Stomach
Authors: Alan I. Harris
Journal: JAMA (1978)

CARCINOID tumors of the stomach are rare. To our knowledge, there are 93 cases reported in the literature before 1970.<sup>1</sup>Numerous gastric carcinoids are more unusual, with nine reports before 1971.<sup>2,3</sup>There have been four cases of pernicious anemia associated with gastric carcinoid mentioned in the English literature,<sup>1,2,4,5</sup>one of which concerned a patient with seven tumors in his stomach.<sup>2</sup>We treated a patient with pernicious anemia and gastric carcinoid. This report also represents the second case of numerous (four) tumors in a patient with pernicious anemia. It also demonstrates the value of endoscopic biopsy in the diagnosis of these lesions before surgery.<sup>1,3</sup> <h3>Report of a Case</h3> A 33-year-old man was admitted to the Mount Sinai Hospital in May 1976 because of a polypoid defect detected in the stomach during an upper gastrointestinal (GI) tract series. The patient had pernicious anemia since March 1974 but
Human Mesenchymal Stem Cells Maintain Transgene Expression during Expansion and Differentiation
Authors: Keunmyoung Lee, Manas K. Majumdar, Diana Buyaner, J.Kyle Hendricks, Mark F. Pittenger, Joseph D. Mosca
Journal: Molecular Therapy (2001)

Human adult bone marrow contains both hematopoietic stem cells that generate cells of all hematopoietic lineages and human mesenchymal stem cells (hMSCs), which support hematopoiesis and contribute to the regeneration of multiple connective tissues. The goal of the current study was to demonstrate that transduced hMSCs maintain transgene expression after stem cell differentiation in vitro and in vivo. We have introduced genes into cultured hMSCs by retroviral vector transfer and demonstrated long-term in vitro and in vivo expression of human interleukin 3 (hIL-3) and green fluorescent protein (GFP). Protocols were developed to achieve transduction efficiencies of 80-90% in these stem cells. In vitro expression of hIL-3 averaged 350 ng/10(6)cells/24 h over 17 passages (> 6 months) and GFP expression was stable over the same time period. Transduced hMSCs were able to differentiate into osteogenic, adipogenic, and chondrogenic lineages and maintained transgene expression after differentiation. Parallel studies were performed in vivo using NOD/SCID mice. Human MSCs expressing hIL-3 were cultured on several matrices and then delivered by subcutaneous, intravenous, and intraperitoneal routes. Sampling of peripheral blood demonstrated that systemic hIL-3 expression was maintained in the range of 100-800 pg/ml over a period of 3 months. These results illustrate the ability of hMSCs to express genes of therapeutic potential and demonstrate their potential clinical utility as cellular vehicles for systemic gene delivery.
Vitamin C and Growth-Reply
Authors: Judy Z. Miller
Journal: JAMA (1977)

We agree with Jukes thatour data provide no overall evidence for a treatment effect of pharmacologic doses of vitamin C on growth and clearly stated this in our article. However, we did observe significant heterogeneity by analysis of variance in the response to vitamin C among treatment groups (<i>P</i>&lt;.05) and, as reported, found an apparent effect on growth in the male twins receiving 500 mg per day (<i>P</i>&lt;.01) when individual group means were compared. The actual measurements are given in Table 2, where it can be seen that six of the seven treated male twins grew more than their co-twins, while in the seventh pair there was no difference in growth. We disagree with Jukes' statement that "an opposite conclusion could just as easily... be drawn from the 1,000 mg/day figures for male twins," since the mean difference for this group was less than twice
Production of Endocarditis with Staphylococcus Aureus and Streptococcus Mitis in Dogs with Aortic Insufficiency
Authors: BENJAMIN HIGHMAN, JOSEPH ROSHE, PAUL D. ALTLAND
Journal: Circulation Research (1956)

Following the induction of aortic insufficiency, 15 dogs received intravenous injections of either Staphylococcus aureus or Streptococcus mitis . The clinical course and pathologic picture resembled those of acute and subacute bacterial endocarditis respectively. The valvular lesions were confined largely to contacting surfaces of aortic and mitral leaflets. The dogs given S. mitis often developed an acute diffuse proliferative glomerulonephritis. No such valvular or renal lesions were noted in 10 control dogs, including 2 with sham operations, given similar bacterial injections.
Delayed Gadolinium-Enhanced Cardiac Magnetic Resonance in Patients With Chronic Myocarditis Presenting With Heart Failure or Recurrent Arrhythmias
Authors: Francesco De Cobelli, Maurizio Pieroni, Antonio Esposito, Cristina Chimenti, Elena Belloni, Renata Mellone, Tamara Canu, Gianluca Perseghin, Carlo Gaudio, Attilio Maseri, Andrea Frustaci, Alessandro Del Maschio
Journal: Journal of the American College of Cardiology (2006)
Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo
Authors: Min-Jung Park, Dong-Il Kim, Seul-Ki Lim, Joo-Hee Choi, Jong-Choon Kim, Kyung-Chul Yoon, Jee-Bum Lee, Jae-Hyuk Lee, Ho-Jae Han, In-Pyo Choi, Hyoung-Chin Kim, Soo-Hyun Park
Journal: Journal of Hepatology (2014)
Relation between gastric emptying rate and rate of intraluminal lipolysis.
Authors: B D Maes, Y F Ghoos, B J Geypens, M I Hiele, P J Rutgeerts
Journal: Gut (1996)

The variable gastric emptying rate of a test meal is one of the major problems in evaluating accurately gastrointestinal physiological functions beyond the stomach. The aim of this study was to evaluate the effect of the gastric emptying rate on the rate of intraluminal lipolysis. Thirty four subjects without pancreatic disease (21 with a normal gastric emptying and 13 with a known slow gastric emptying) and 14 subjects with pancreatic disease (four without and 10 with pancreatic insufficiency) were studied using a dual labelled breath test. The test meal consisted of one egg, 60 grams of white bread, 10 grams of margarine, and 150 ml of water (350 kcal). The egg yolk was labelled with 91 mg of 13C-octanoic acid, the margarine was labelled with 296 kBq of distearyl-2-14C-octanoyl-glycerol. Breath samples were taken every 15 minutes during six hours and analysed for 13CO2 and 14CO2 content. The gastric emptying rate of the meal was evaluated by the gastric emptying coefficient, the half emptying time, and the lag phase; the rate of intraluminal lipolysis was evaluated by the six hours cumulative 14CO2 excretion. Despite a clear distinction in the rate of intraluminal lipolysis, no difference could be detected in gastric emptying rate of the test meal between subjects without and with pancreatic disease. In subjects with pancreatic insufficiency, intraluminal hydrolysis was the rate limiting process in fat assimilation; in patients without pancreatic insufficiency, however, gastric emptying could be rate limiting. Therefore, patients with known slow gastric emptying, displayed a significantly decreased rate of intraluminal lipolysis compared with normal controls. This decrease could be corrected for accurately using a correction factor based on the gastric emptying coefficient. In conclusion, the combined 13C-octanoic acid and 14C-mixed triglyceride breath test permits the measurement of gastric emptying rate and intraluminal lipolysis simultaneously in a minimally invasive way. Correction of intraluminal lipolysis rate for gastric emptying rate of the given test meal permits evaluation of fat assimilation rates in a physiological way regardless of gastric emptying disorders.
ROLE OF THREE-DIMENSIONAL SPECKLE TRACKING AREA STRAIN TO QUANTIFY ‘WASTED ENERGY’ AND PREDICT RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY: A PILOT STUDY
Authors: Anna Kydd, Fakhar Khan, Liam Ring, Peter Pugh, Munmohan Virdee, David Dutka
Journal: Journal of the American College of Cardiology (2014)
Pre-Clinical Efficacy of RP6503 in PI3Kδ/γ Mediated Airway Disorders
Authors: Swaroop Vakkalanka, Babu Govandarajulu, Kasiviswanath Routhu, Sridhar Veeraraghavan, Srikant Viswanadha, Dhanapalan Nagarathnam
Journal: Journal of Allergy and Clinical Immunology (2013)
Hormonal therapy for oestrogen receptor-negative breast cancer is associated with higher disease-specific mortality
Authors: A. Merglen, H.M. Verkooijen, G. Fioretta, I. Neyroud-Caspar, V. Vinh-Hung, G. Vlastos, P.O. Chappuis, M. Castiglione, E. Rapiti, C. Bouchardy
Journal: Annals of Oncology (2009)
PNEUMOTHORAX IN A BOY AGED 7: RECOVERY: Clinical and X-Ray Reports
Authors: W. B. Martin, R. Knox
Journal: BMJ (1922)

TRAUMATIC ARTERIO-VENOUS ANEURYSM.rMTiAJovITI 25 92 EICLJUtA never very intenise, but it continued.Abdominal, or for that matter any, aneuLrysm is so rare in a woman that neither the husban(d nor any of his medical friends believed in my diagnosis.Eventually the, patient saw by mv wish an eminent Londoni surgeoni, who scoffed at the idea of an aneurysm, anld promised immediate relief by removing an ovary adherent to the aorta.However, at the operation lie found no such adherent ovary, but a well-marked aneurysm, and the patient has continued to suffer pain ever since.But this case and other recorded cases did not suffer from tlhe intense pain and restlessness displayed in our case.Dr. Gates and I tlhouglht, thlerefore, that we were dealing witlh a dissecting aneurysm, and that the separation of tlle coats of the aorfa was the cause of the intense pain described.A dissecting aneurysm would also more probably account for a small leakage of blood into the pleural cayity, and so for the dullness found at tlle base of the left pleura.Having, then, made our diagnosis, we thought we might get-con-firmation of it by an x-ray photograph, and Dr.Hodgson, lhead of the electrical department at the Royal Devon and Exeter Hospital, having a movable apparatus that hle can take to patients' lhouses, we asked him to take a radio- gram of the chest.This lie did three days after tlle onset, and tliis-radisgramn (see Special Plate) clearly shows an aneurysm arising near the archl of the aorta.Thle patient lived for nineteen days after the onset of the symptoms, being kept quiet in bed, and his pain kept in abeyance by an injection of 1/4 grain of morphine night and morning.On two occasions during this time he had severe
10T1/2 cells: an in vitro model for molecular genetic analysis of mesodermal determination and differentiation.
Authors: D F Pinney, C P Emerson
Journal: Environmental Health Perspectives (1989)

Progress has been made in understanding the molecular mechanisms that regulate cell type-specific gene expression during the terminal differentiation of cells into specialized tissue types. These studies have concentrated largely on defining the cis elements and trans-acting factors responsible for the transcription of differentiation-specific genes. Valuable as these investigations have been, they have not been able to place differentiation into the larger context of development, specifically into the context of the earlier developmental process of cell determination, when embryonic stem cell lineages are formed and the genetic regulatory programs for cell type-specific gene activation and expression are acquired by stem cells. The clonal mouse embryo cell line, C3H/10T1/2, clone 8 (10T1/2) provides a unique opportunity to examine the molecular genetic regulation of both the developmental determination of vertebrate stem cell lineages and their subsequent differentiation. 10T1/2 is an apparently multipotential cell line that can be converted by 5-azacytidine into three mesodermal stem cell lineages. These determined proliferative stem cells are stable in culture and retain their ability to differentiate in mitogen-depleted medium. The most significant discovery has been that 10T1/2 lineage determination is under simple genetic control and that the regulatory genes that mediate the formation of myogenic cell lineages, and likely the chondrogenic and adipogenic lineages, can be demonstrated and studied by genomic DNA and cDNA transfection approaches. This paper is a description of the remarkable properties and genetic behaviors of the 10T1/2 cells and a discussion of the insights that future studies of this cell may provide.
BOCK'S STETHOSCOPE AS AN AID TO DETERMINING THE EFFICIENCY OF THE MYOCARDIUM
Authors: J. Ramsay
Journal: BMJ (1916)

EVERY plhysician is agreed as to the occasional difficulty in estinmating the efficiency or othervise of the hleart nmuscle, wlichl is a factor of paramount importance in prognosis.Cases occtIr from timne to titne vwhich present some of tlle symiiptoms, suchl as dizziness or breatlhlessness on exertion, ,which arc coiunion bothl to actual flagging of the myo- cardial power alnd to vasoluotor instability.In spite of careful inquiry into time hlistory of tlle case, and in spite of tlle mnaniy accurate methods of investigation whl ichl are lnowadays at our commn-iand, we cannot invariably formu a perfectly definite opinion as to tlle cause of the patient's symuptoms.Any new iinstrument, therefore, wlhiclh can lhelp us in our decisions sliould be of real use to the profession.During a discuission on tlle soldier's lheart, reportedl
P2-13-05: Breast Cancer, BRCA Mutations and Attitudes Regarding Pregnancy and Preimplantation Genetic Diagnosis.
Authors: JK Litton, CJ Etzel, MA Jackson, KI Muse, D Turco, LR Schover, RL Theriault, D Mattair, KH Lu, GN Hortobagyi, BK Arun
Journal: Cancer Research (2011)

Abstract Background: Breast cancer is associated with treatment-related infertility and has been demonstrated to be a major concern for premenopausal survivors. Detection of a BRCA deleterious mutation may also affect attitudes regarding future childbearing. Preimplantation genetic diagnosis (PGD) allows women to use in vitro fertilization (IVF) to implant only those embryos without a BRCA mutation. The ability to test the fetus for BRCA mutations is also available through amniocentesis and chorionic villus sampling (CVS). The objective of this study was to evaluate attitudes about childbearing and fertility in women being evaluated for a BRCA mutation. Methods: Women with childbearing potential who were referred to the Clinical Cancer Genetics Clinic to be evaluated for a BRCA mutation were invited to participate in this survey. The questionnaire was administered prior to genetic counseling. A follow-up was administered after the BRCA results were disclosed. The survey queried participants regarding their attitudes on fertility, pregnancy as it may relate to cancer and the potential of a BRCA mutation. Other questions detailed attitudes regarding IVF, PGD, and CVS in these instances. Descriptive statistics were used. Results: One hundred and twenty-eight women completed pre-questionnaires and to date 76 have completed post results disclosure questionnaires. The mean age was 33 (range 21–44) with 69.5% with a diagnosis of breast cancer, 39.8% received chemotherapy and 60.9% already had at least 1 biological child. A future child was desired by 45.3% although 53.1% worried that their children would have an increased risk of cancer. Regarding PGD, although only 30.9% (38/123) said that they would use PGD, 80.2% felt that the testing should be available to families with inherited cancers. Regarding fetal testing via amniocentesis or CVS, 29.7% would have the fetus tested and 7% would consider termination if a genetic mutation was identified. Additionally, 69.5% felt it was important to receive fertility counseling and treatment at the same place where they receive their cancer care. To date 8 women have been diagnosed with a BRCA1 mutation and 4 with a BRCA2 mutation. When asked similar questions after their genetic results were disclosed, 2 women who had previously stated they would not use PGD changed their mind. Conclusions: Future pregnancies are important to many breast cancer survivors. BRCA mutation carriers have the option to have children without passing on their genetic risk for cancer. Although few would use these interventions, a large majority felt it was important to have information about these choices and to have options for fertility preservation options addressed at the center where cancer care is delivered. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-13-05.
416 LONGITUDINAL PROSPECTIVE COMPARISON OF FIBROSURE AND TRANSIENT ELASTOGRAPHY IN RELATION TO VIROLOGIC RESPONSE: A SUBSTUDY OF THE PHASE 3 ALBINTERFERON ALFA-2B TRIALS
Authors: K. Patel, M. Friedrich-Rust, M. Torbenson, Y. Zhu, E. Pulkstenis, G. Subramanian, J. McHutchison, D. Nelson, M. Sulkowski, Y. Benhamou, S. Zeuzem
Journal: Journal of Hepatology (2010)
Points from letters: Spontaneous explosion of glass door
Authors: J. G Rennie
Journal: BMJ (1976)

Government's spokesmen, including the Prime Minister, admit that the counter-inflation policy of 1975-6 was unjust to certain members of the community, including consultants on the incremental scale.They argue, however, that the steps were necessary in the national interest.The professions' negotiators did not 'acquiesce' in the imposition of this counterinflation policy, but vigorously opposed it- and succeeded in securing the modification for 1976-7 which has allowed the incremental scales to be reactivated.The withholding of contractual increments (and distinction awards) which has in effect meant for some consultants a 12-month wait for what they were entitled to was secured by the Remuneration, Charges, and Grants Act 1975-which rapidly went through Parliament without opposition and specifically allows employing authorities to breach contracts in this respect."-ED, BMJ. Keeping tabs on trainers
The So-Called Normal
Authors: William L. Pritchard
Journal: JAMA (1964)

<h3>To the Editor:—</h3> I have had considerable experience with discography, and from the radiologic standpoint I would agree that the so-called normal discogram is an unusual finding. This is particularly true in patients with symptoms attributable to degenerative disk disease. The chief localizing value of the procedure is to reproduce root symptoms. With a cooperative patient who is able to report objectively it is possible to pinpoint the level at which nerve root compression is causing symptoms, but I think that the same information can be obtained by cervical myelography with a good deal less discomfort to the patient.
Specificity of the Carcinoembryonic Antigen (CEA)
Authors: Jeffrey J. Collins, Paul H. Black
Journal: New England Journal of Medicine (1971)

Beginning in 1965, a series of elegant studies by Gold and his colleagues have been carried out involving the detection and characterization of a new, apparently specific, surface antigen associated with adenocarcinoma of the human colon. This particular tumor was chosen for study because of its highly localized nature; thus, both control and tumor tissue could be obtained from the same patients, thereby eliminating isoantigenic complications in the search for a "tumor-specific" antigen.1 Heterologous immune rabbit serums were made specific for tumor antigens both by adsorption with control colon tissue and by immunization of rabbits previously made tolerant to control . . .
Dietary management of maturity-onset diabetes.
Authors: E A Wilson, D R Hadden, J D Merrett, D A Montgomery, J A Weaver
Journal: BMJ (1980)

Dietary management of maturity-onset diabetes is a basic medical concept. It is difficult to study scientifically because of variable eating habits and the impossibility of rigorous measurement. The non-insulin-requiring diabetic patient is often managed by the family doctor, who may not have access to dietetic assistance, and assessment of the success of simple but careful dietary measures is infrequent. We have taken a special interest in this group of patients, and find that most maturity-onset diabetic patients can be satisfactorily managed on diet only. In a group of 58 such patients there was a significant fall in mean weight and fasting plasma glucose and triglyceride concentrations after six months, which persisted for up to three years. This achievement was chiefly due to those patients who were graded as "good" in their dietary adherence, but less good dieting still achieved weight loss, though plasma glucose and triglyceride concentrations did not fall so low. The clinical dietitian has played a central part in this study.
Endoscopic Features of Helicobacter pylori-Related Gastritis
Authors: A. Bah, E. Saraga, D. Armstrong, D. Vouillamoz, G. Dorta, P. Duroux, B. Weber, F. Froehlich, A. L. Blum, J. F. Schnegg
Journal: Endoscopy (1995)

Background and Study Aims: It is still controversial whether certain endoscopic features can be used to diagnose Helicobacter pylori (Hp)-related gastritis. To clarify this issue, we performed two consecutive prospective studies.