Exercise Training for Diabetes: The “Strength” of the Evidence
Authors: William E. Kraus, Benjamin D. Levine
Journal: Annals of Internal Medicine (2007)

Editorials18 September 2007Exercise Training for Diabetes: The "Strength" of the EvidenceWilliam E. Kraus, MD and Benjamin D. Levine, MDWilliam E. Kraus, MDFrom Duke University Medical Center, Durham, NC 27710, and Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75231. and Benjamin D. Levine, MDFrom Duke University Medical Center, Durham, NC 27710, and Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75231.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-6-200709180-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Exercise is an essential component in the treatment of diabetes mellitus. Lifestyle factors affect the prevention, development, and treatment of diabetes mellitus and its close relation, the metabolic syndrome (1). The Finnish Diabetes Prevention Study (2) and the Diabetes Prevention Program (3) tested lifestyle interventions that included a physical activity program. Both studies showed the power of exercise, nutrition, and weight loss to prevent diabetes mellitus in at-risk individuals.However, exercise comes in several flavors, and the clinician should think critically about the effects of different types of exercise training. It is useful to think of exercise training as a ...References1. Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C. Physical activity/exercise and type 2 diabetes. Diabetes Care. 2004;27:2518-39. [PMID: 15451933] CrossrefMedlineGoogle Scholar2. Laaksonen D, Lindstrom J, Lakka T, et al; Finnish Diabetes Prevention Study. Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. Diabetes. 2005;54:158-65. [PMID: 15616024] CrossrefMedlineGoogle Scholar3. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393-403. [PMID: 11832527] CrossrefMedlineGoogle Scholar4. Levine BD, Stray-Gundersen J. Dose-response of altitude training: how much altitude is enough? Adv Exp Med Biol. 2006;588:233-47. [PMID: 17089893] CrossrefMedlineGoogle Scholar5. Iwasaki K, Zhang R, Zuckerman JH, Levine BD. Dose-response relationship of the cardiovascular adaptation to endurance training in healthy adults: how much training for what benefit? J Appl Physiol. 2003;95:1575-83. [PMID: 12832429] CrossrefMedlineGoogle Scholar6. Slentz CA, Houmard JA, Kraus WE. Modest exercise prevents the progressive disease associated with physical inactivity. Exerc Sport Sci Rev. 2007;35:18-23. [PMID: 17211189] CrossrefMedlineGoogle Scholar7. Rådegran G. Ultrasound Doppler estimates of femoral artery blood flow during dynamic knee extensor exercise in humans. J Appl Physiol. 1997;83:1383-8. [PMID: 9338449] CrossrefMedlineGoogle Scholar8. Baldwin KM, Haddad F. Skeletal muscle plasticity: cellular and molecular responses to altered physical activity paradigms. Am J Phys Med Rehabil. 2002;81:S40-51. [PMID: 12409810] CrossrefMedlineGoogle Scholar9. Sigal RJ, Kenny GP, Boulé NG, Wells GA, Prud'homme D, Fortier M, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes. A randomized trial. Ann Intern Med. 2007;147:357-69. LinkGoogle Scholar10. Selvin E, Marinopoulos S, Berkenblit G, Rami T, Brancati FL, Powe NR, et al. Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med. 2004;141:421-31. [PMID: 15381515] LinkGoogle Scholar11. Duscha BD, Slentz CA, Johnson JL, Houmard JA, Bensimhon DR, Knetzger KJ, et al. Effects of exercise training amount and intensity on peak oxygen consumption in middle-age men and women at risk for cardiovascular disease. Chest. 2005;128:2788-93. [PMID: 16236956] CrossrefMedlineGoogle Scholar12. Balady GJ, Williams MA, Ades PA, Bittner V, Comoss P, Foody JM, et al; American Heart Association Exercise. Cardiac Rehabilitation, and Prevention Committee. the Council on Clinical Cardiology. Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation. Circulation. 2007;115:2675-82. [PMID: 17513578] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: William E. Kraus, MD; Benjamin D. Levine, MDAffiliations: From Duke University Medical Center, Durham, NC 27710, and Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75231.Disclosures: None disclosed.Corresponding Author: Benjamin D. Levine, MD, Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231; e-mail, [email protected]org.Current Author Addresses: Dr. Kraus: Duke University Medical Center, 1033 GSRB1, 595 Lasalle Street, Durham, NC 27710.Dr. Levine: University of Texas Southwestern Medical Center at Dallas, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Aerobic Training, Resistance Training, or Both on Glycemic Control in Type 2 Diabetes Ronald J. Sigal , Glen P. Kenny , Normand G. Boulé , George A. Wells , Denis Prud'homme , Michelle Fortier , Robert D. Reid , Heather Tulloch , Douglas Coyle , Penny Phillips , Alison Jennings , and James Jaffey Metrics Cited byObesity Indices and Ventilatory Function Responses to High-Level Laser Therapy in Subjects with Abdominal ObesityOne-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection FractionEffectiveness training type on body composition and metabolic parameters in adolescents with obesity: reviewComparison of Baroreflex Sensitivity and Cardiac Autonomic Function Between Adolescent Athlete and Non-athlete Boys – A Cross-Sectional StudyExercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitusExercise and the autonomic nervous systemPhysical Exercise, Sports, and DiabetesGold standards for scientists who are conducting animal-based exercise studiesImpaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscleRole of Physical Activity in Diabetes Management and Prevention 18 September 2007Volume 147, Issue 6Page: 423-424KeywordsAerobic exerciseExerciseGlucoseHemoglobinLipidsMuscle contractionMuscle proteinsMusclesSkeletal musclesStrength training ePublished: 18 September 2007 Issue Published: 18 September 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. 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