tbuckley/cabot-search huggingface dataset:
Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5–grass pollen tablet for seasonal allergic rhinitis
Authors: Alain Didier, Hans-Jörgen Malling, Margitta Worm, Friedrich Horak, Siegfried Jäger, Armelle Montagut, Claude André, Olivier de Beaumont, Michel Melac
Journal: Journal of Allergy and Clinical Immunology (2007)
Low back pain: Sacroiliac joint pain may be myth
Authors: Andrew N Bamji
Journal: BMJ (2004)

Firm foundation for senior house officers Five years is long enoughEditor-The editorial by Gallen and Peile signals anything but a firm foundation for training junior doctors. 1 The first foundation year will essentially be an extension of undergraduate training, its doctors allowed only to observe medical practice.And doctors in foundation year 2 will be "career tourists," spending too little time in each specialty to be able to offer much service in return.Medical educationalists should realise that nurses and other paramedical groups are encroaching on traditional medical practice and do not seem to need the sort of extended training we demand of medical students.For example, a six week course apparently enables paramedics to administer safely almost all drugs used in emergency practice.By contrast we seem intent on postponing the time at which our bright and enthusiastic young doctors can start treating patients.Five years is quite long enough to learn the theory of medicine.After that, the sooner young doctors are allowed to start treating patients, in a supervised setting, the better.
Spillover Effects on Treatment of Adult Depression in Primary Care After FDA Advisory on Risk of Pediatric Suicidality With SSRIs
Authors: Robert J. Valuck, Anne M. Libby, Heather D. Orton, Elaine H. Morrato, Richard Allen, Ross J. Baldessarini
Journal: American Journal of Psychiatry (2007)

Objective: In 2003, the U.S. Food and Drug Administration (FDA) issued a public health advisory about the risk of suicidality in pediatric patients taking selective serotonin reuptake inhibitors (SSRIs) for depression, and in 2005, the agency mandated a black box warning and medication guide indicating that pediatric and adult patients may be at risk. The authors examine the effects of this pediatric policy on treatment of adult depression in the community. Method: An adult cohort with newly diagnosed episodes of depression was created from a large national integrated claims database of managed care plans from October 1998 to September 2005 (N=475,838 unique episodes). Time-series analyses were used to compare the post-FDA advisory trends to the trends during the 5 years preceding the advisory. Results: The rate of diagnosed depression was significantly lower after the advisory than would have been expected on the basis of the preadvisory historical trend. The average percentage of adults with new (versus recurrent) depressive episodes was 88.6% in the preadvisory period (declining at an annual rate of 1.69%), and it decreased significantly to 77.5% (declining more rapidly, at an annual rate of 7.70%). The percentage of adults with depression who did not receive an antidepressant increased from an average of 20% (declining at 0.45% annually) before the policy action to an average of 30% (increasing at an annual rate of 20.6%). The data did not show any compensatory increases in psychotherapy or prescription of atypical antipsychotics or anxiolytics. Conclusions: The FDA advisory had a significant spillover effect into community treatment for adults with depression, despite the focus of the policy on pediatric patients.
Foundation of the Lane Course of Medical Lectures in Cooper Medical College.
Authors: Levi Cooper Lane
Journal: JAMA (1895)

San Francisco, Cal., Dec. 8, 1895. <h3>To the Editor:</h3> —The undersigned announces that in accordance with a purpose which he has long entertained he has founded a course of lectures to be annually given in Cooper Medical College, and the same to constitute a part of the instruction given in this institution. The matter of these lectures shall be some subject within the domain of medical art and science; and they shall be ten or more in number, according to the option of the lecturer. The lecturer selected to deliver this course shall be a man of superior eminence in the profession of medicine, and his selection shall be irrespective of nationality. The lectures are to be given in the English language and are to remain the property of their author. These lectures, when it is practicable to the lecturer, shall be delivered as the initial ones of the semester
Survival time in a population-based consecutive series of adult acute myeloid leukemia – the prognostic impact of karyotype during the time period 1976–1993
Authors: N Mauritzson, B Johansson, M Albin, L Rylander, R Billström, T Ahlgren, Z Mikoczy, U Strömberg, F Mitelman, L Hagmar, PG Nilsson
Journal: Leukemia (2000)
Psychiatric Risk Factor ANK3/Ankyrin-G Nanodomains Regulate the Structure and Function of Glutamatergic Synapses
Authors: Katharine R. Smith, Katherine J. Kopeikina, Jessica M. Fawcett-Patel, Katherine Leaderbrand, Ruoqi Gao, Britta Schürmann, Kristoffer Myczek, Jelena Radulovic, Geoffrey T. Swanson, Peter Penzes
Journal: Neuron (2014)
Functional differentiation of human jejunum and ileum: A comparison of the handling of glucose, peptides, and amino acids
Authors: D. B. A. Silk, J. P. W. Webb, A. E. Lane, M. L. Clark, A. M. Dawson
Journal: Gut (1974)

The characteristics of glucose, glycine, L-alanine, and glycyl-L-alanine absorption from the jejunum and ileum have been compared in normal human subjects. A perfusion technique has been used, and correct positioning of the perfusion tube has been confirmed by measuring the differential jejunal and ileal handling of bicarbonate. Glucose and glycine were absorbed faster from the jejunum than from the ileum of all subjects studied, and L-alanine was absorbed faster from the jejunum than from the ileum in five out of six subjects studied. In contrast, the dipeptide glycyl-L-alanine was absorbed at comparable rates from the jejunum and ileum. Higher concentrations of free amino acids were detected in the luminal contents aspirated during the ileal dipeptide perfusions. These results emphasize the importance of oligopeptide transport in the absorption of protein digestion products, especially in the human ileum, and the practical implications of these findings are discussed.
The Clinic as an Interpersonal Field of Dynamic Psychiatric Treatment of Psychosomatic Diseases
Authors: Jan Pohl
Journal: Psychotherapy and Psychosomatics (1979)

In Günter Ammon's structural personality model, psychosomatic illnesses are understood to be the expression of a structural ego-defect – especially in the central ego-function of the body-ego, of identity and of constructive aggression – which owes its origin to an insufficient mother-child symbiosis. The dynamic psychiatric clinic realises an interpersonal field, into which the defects are externalised and remedied by the process of a late ego development. The clinic offers various therapeutical levels: the clinic as a whole, the analytical milieu, group and individual therapy, whereby working-through of the interdependence of patient and staff dynamics has a main integrating function.
Attitudes and advice after myocardial infarction.
Authors: R Mayou, B Williamson, A Foster
Journal: BMJ (1976)

While medical opinion increasingly favours an active approach to rehabilitation after myocardial infarction, interviews with 40 patients and their relatives showed a low degree of understanding of medical advice and information. There was general satisfaction with treatment, but communication was seen as often being inadequate, vague, and conflicting.
Combined MUC1-specific nanobody-tagged PEG-polyethylenimine polyplex targeting and transcriptional targeting of tBid transgene for directed killing of MUC1 over-expressing tumour cells
Authors: Elham Sadeqzadeh, Fatemeh Rahbarizadeh, Davoud Ahmadvand, Mohammad J. Rasaee, Ladan Parhamifar, S. Moein Moghimi
Journal: Journal of Controlled Release (2011)
The Editor, 'The British Journal of Dermatology'. Psoriasis and folic acid antagonists.
Authors: A. W. McKenzie, C. V. E. Aitken
Journal: British Journal of Dermatology (1967)

Journal Article The Editor, ‘The British Journal of Dermatology’. Psoriasis and folic acid antagonists. Get access A. W. McKenzie, A. W. McKenzie Norfolk and Norwich Hospital, Norwich Search for other works by this author on: Oxford Academic Google Scholar C. V. E. Aitken C. V. E. Aitken Norfolk and Norwich Hospital, Norwich Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 2, 1 February 1967, Pages 122–123, https://doi.org/10.1111/j.1365-2133.1967.tb11469.x Published: 01 February 1967
Second children's cardiac surgery unit set for closure takes its case to High Court
Authors: C. Dyer
Journal: BMJ (2013)

<h3>Background</h3> Ankle sprains are the most common injury among basketball players. However, a number of athlete report persisting symptoms which can lead to the chronic ankle instability (CAI), even worse, their articular cartilage damage. <h3>Objective</h3> To investigate the prevalence of ankle sprains and the relationships between recurrence, perceived instability, ATFL pathology, range of motion and the balance test among elite high school basketball players. <h3>Design</h3> Cross-sectional study. <h3>Setting</h3> High school national championship tournament in 2017. <h3>Patients (or Participants)</h3> All players who voluntarily participated in our checkup. <h3>Interventions (or Assessment of Risk Factors)</h3> Questionnaire, ultrasonographic examination for anterior talofibular ligament (ATFL) pathology, ankle dorsi-flexion (DF) angle measurement and star excursion balance test (SEBT). <h3>Results</h3> We received the responses from 1013 players (330 male and 683 female players). It revealed that 74.3% of males and 82.7% of females had injured their ankle at least once and recurrence rate was 59.6% and 63.0% respectively. 79.3% of players were injured before 16 years of age. Fifty-two male and 77 female players completed all examinations. It was revealed that the players who had recurrent sprains suffered more severe ATFL injuries and felt unstable sensation in their ankle compared with the players without sprain. Players who got ATFL tear had smaller DF angle significantly. Additionally, DF angle significantly correlated with the reach of SBET. Logistic regression analysis indicated that ATFL tear and Unstable sensation were significantly associated with recurrent sprains, and multiple regression analysis revealed that DF angle and gender were only variables to predict SEBT length. <h3>Conclusions</h3> Prevention of the CAI should be focused on the following 3 points:1) Education for younger, pre-injury age, 2) Treatment just after their first injury with an emphasis on the ATFL healing and range of motion restoration, 3) Appropriate exercises and/or equipment for prevention from recurrence.
Miniprobe Ultrasonography in the Upper Gastrointestinal Tract: State of the Art 1995, and Prospects
Authors: J. Menzel, W. Domschke, H.-J. Brambs, N. Frank, A. Hatfield, C. Nattermann, S. Ødegaard, H. Seifert, K. Tamada, T. L. Tio, E.-C. Foerster
Journal: Endoscopy (1996)
Protein phosphorylation and cardiac function: cholinergic-adrenergic interaction
Authors: S Bartel, P Karczewski, E-G Krause
Journal: Cardiovascular Research (1993)

Objective: The muscarinic inhibition of cyclic AMP (cAMP) mediated contractile effects may not only be the result of a reduction in cAMP levels, but may also involve cAMP linked protein phosphorylation in the heart. To show that a cholinergic agonist may antagonise the effects of agents that induce the cAMP signalling sequence at the level of protein phosphorylation, the effect of carbachol was investigated on the in vivo phosphorylation of phospholamban. troponin I, and a 15 kDa protein during positive inotropic intervention with isoprenaline, forskolin, and a phosphodiesterase inhibitor in the isolated rat heart. Methods: The contractile activity of the heart was monitored during drug administration, and the hearts were freeze clamped for assay of protein phosphorylation and metabolites [cAMP. cyclic guanosine monophosphase (cGMP), cAMP dependent protein kinase (cA-PK), and phosphorylase a]. For estimation of the amount of in vivo phosphorylation, a "back phosphorylation" method was used. Results: Carbachol attenuated in vivo phosphorylation, induced by cAMP increasing drugs, of all the phosphoproteins studied, whereas the accumulation of cAMP was not affected or was decreased to 61% after exposure to isoprenaline alone. In addition, the cAMP mediated phosphorylase a activation was completely reversed by carbachol. Similarly, sodium nitroprusside reduced phosphorylation as well as the contractile force of the investigated phosphoproteins. Conclusions: These data confirm the reduction of cAMP mediated cardiac protein phosphorylation by carbachol. The cholinergic antagonism may primarily involve cellular target systems distal to sites of cAMP generation. The observed similarity in the cardiac response to carbachol and sodium nitroprusside indicates a role of cGMP in the antiadrenergic action of carbachol in the myocardium. Cardiovascular Research 1993:27: 1948-1953
Dynamic Right Ventricular Outflow Tract Obstruction Due to a Swinging Echolucent Cyst on Interventricular Septum in a 4-Year-Old Girl
Authors: Noriko Sugino, Yoshihide Mitani, Hiroyuki Ohashi, Hidetoshi Hayakawa, Koa Hosoki, Shin Takabayashi, Hideto Shimpo, Yoshihiro Komada
Journal: Circulation (2010)
Vaselin as a Menstruum.
Authors: M. Lewis Emerson
Journal: JAMA (1903)

Oakland, Cal., July 29, 1903. <i>To the Editor:</i>—In the discussion on the paper "Treatment of Scarlet Fever, Its Complications and Sequelæ," by Dr. H. M. McClanahan, July 4, Dr. G. A. Hermann refers to the method of preparing a 10 per cent. ointment of carbolic acid in vaselin, while the Doctor does not state that he uses this strength in the ointment. One would infer that he does, or why does he mention it at all? I wish to emphasize the absolute pharmaceutic incompatibility of a 10 per cent, ointment of vaselin, a 5 per cent. or even a 3 per cent. ointment of this hydrocarbon, which is altogether devoid of oxygen; 2 per cent. carbolic acid is all it will take up; 3 per cent, can be made by mixing equal parts of carbolic acid and camphor and then adding the vaselin. Even a 2 per cent. must
A Pilot Study of Hypnosis in the Treatment of Patients with Psoriasis
Authors: Francisco Tausk, S. Elizabeth Whitmore
Journal: Psychotherapy and Psychosomatics (1999)

&lt;b&gt;Background:&lt;/b&gt; The use of psychological therapies for patients with psoriasis has been proposed based on observations that the severity of their disease may correlate with emotional stress. The aim of this pilot study was to evaluate the effect of hypnosis as a treatment modality for patients with psoriasis. &lt;b&gt;Methods:&lt;/b&gt; We performed a 3-month randomized, single-blind, controlled trial of the use of hypnosis in adults with stable, chronic, plaque-type psoriasis. Highly or moderately hypnotizable subjects were randomized to receive either hypnosis with active suggestions of improvement (5 patients) or neutral hypnosis with no mention of their disease process (6 patients). After this period, the study was unblinded, and all the patients were treated for an additional 3 months with hypnosis with active suggestions of improvement. &lt;b&gt;Results:&lt;/b&gt; Highly hypnotizable subjects showed significantly greater improvement than did moderately hypnotizable subjects, independent of treatment group assignment (active suggestion or neutral hypnosis). &lt;b&gt;Conclusion:&lt;/b&gt; Although this study included a very limited number of patients, the results suggest that hypnosis may be a useful therapeutic modality for highly hypnotizable subjects with psoriasis, and merits further testing in a larger patient population.
The cGMP-gated channel of photoreceptor cells: Its structural properties and role in phototransduction
Authors: Robert S. Molday, Yi-Te Hsu
Journal: Behavioral and Brain Sciences (1995)

Abstract The cyclic GMP-gated channel responds to changes in free intracellular cGMP, and as a result, it plays a central role in the phototransduction process in rod and cone photoreceptor cells. Recent biochemical, immunochemical, and molecular biology studies indicate that this channel consists of a complex of two distinct subunits and one or more associated proteins. Primary structural analysis indicates that the a and (3 subunits contain a cGMP-binding domain, an even number of membrane-spanning segments, a voltage sensor motif and a pore region. The latter two features are found in voltage-gated channels and suggest that these two classes of channels have evolved from the same ancestral channel protein. A working model for the membrane topography of the channel subunits is proposed based on immunogold labeling studies and sequence analysis. Recent studies also indicate that calmodulin binds to the 240 kDa protein of the channel complex and modulates the sensitivity of the channel for cGMP in a Ca 2+ -dependent manner. The molecular properties of the channel complex and the possible role of Ca 2+ -calmodulin modulation of the channel during photoactivation and photorecovery are discussed in relation to the current mechanism of phototransduction in photoreceptor cells
Diabetes Mellitus and Thyroid Disease
Authors: Maral Mouradian, Nicolas Abourizk
Journal: Diabetes Care (1983)

Diabetes mellitus not infrequently coexists with hypo- and hyperthyroidism. Hyperthyroidism aggravates glucose intolerance. A review of this phenomenon reveals multiple mechanisms, which include increased hexose intestinal absorption, decreased responsiveness to insulin, and increased glucose production. Conflicting results are obtained when circulating insulin level is measured in thyrotoxicosis. The role of glucagon and a-cell sensitivity is unclear. Diabetes mellitus influences the assessment of thyrotoxicosis by falsely decreasing the blood levels of thyroxine (T4) and triiodothyronine (T3) during severely uncontrolled hyperglycemia. Hypothyroidism is found in about 3% of patients with insulin-dependent diabetes mellitus (IDDM). Moreover, 13–20% of IDDM patients have elevated blood thyrotropin levels and anti-thyroid antibodies. Hypothyroidism per se seems to ameliorate hyperglycemia. A subtype of IDDM shares similar immunogenetic features with familial autoimmune thyroiditis. Studies of IDDM probands who show a high prevalence of circulating thyroid antibodies reveal the presence of such antibodies in their first-degree relatives. Circulating islet-cell antibodies, detected in a majority of IDDM patients at the onset of their disease, tend to persist only in those patients with coexistent polyendocrine autoimmune disease, including thyroiditis. Similar human leukocyte antigen (HLA) locus types are associated with thyroiditis and IDDM, namely HLA-Dr3 and -Dr4.
Diastolic coronary artery pressure-flow velocity relationships in conscious man
Authors: W. P DOLE, K. L RICHARDS, C. J HARTLEY, G. M ALEXANDER, A. B CAMPBELL, V. S BISHOP
Journal: Cardiovascular Research (1984)

We characterised the diastolic pressure-flow velocity relationship in the normal left coronary artery of conscious man before and after vasodilatation with angiographic contrast medium. Phasic coronary artery pressure and flow velocity were measured in ten patients during individual diastoles (0.5 to 1.0 s) using a 20 MHz catheter-tipped, pulsed Doppler transducer. All pressure-flow velocity curves were linear over the diastolic pressure range of 110 +/- 15 (SD) mmHg to 71 +/- 7 mmHg (r = 0.97 +/- 0.01). In the basal state, values for slope and extrapolated zero flow pressure intercept averaged 0.35 +/- 0.12 cm X s-1 X mmHg-1 and 51.7 +/- 8.6 mmHg, respectively. Vasodilatation resulted in a 2.5 +/- 0.5 fold increase in mean flow velocity. The diastolic pressure-flow velocity relationship obtained during peak vasodilatation compared to that during basal conditions was characterised by a steeper slope (0.80 +/- 0.48 cm X s-1 X mmHg-1, p less than 0.001) and lower extrapolated zero flow pressure intercept (37.9 +/- 9.8 mmHg, p less than 0.05). Mean right atrial pressure for the group averaged 4.4 +/- 1.7 mmHg, while left ventricular end-diastolic pressure averaged 8.7 +/- 2.8 mmHg. These observations in man are similar to data reported in the canine coronary circulation which are consistent with a vascular waterfall model of diastolic flow regulation. In this model, coronary blood flow may be regulated by changes in diastolic zero flow pressure as well as in coronary resistance.
Psychotherapie und Strukturwandel der psychiatrischen Institutionen
Authors: W.T. Winkler
Journal: Psychotherapy and Psychosomatics (1972)

The introduction of the principle of a therapeutic community into a since then traditionally working hospital resulted in the observation of certain collective mechanisms of defence (similar to the reaction towards analytical psychotherapy), such as (1) isolation of the concerned patient and staff groups from the other groups, (2) a disavowal of the principles of therapeutic community, and (3) the formation of reaction with building up frontiers between progressive and conservative-minded teams. Only intense efforts could overcome the resistance. The re-organisation of a mental hospital according to the model of a therapeutic community has to be looked at as a process affording many steps and many years. From the social point of view mental hospitals are regarded as 'repression areas for madness' (Kisker), where our society expects the staff to act as a guardian for security and order; that means from a psychoanalytical aspect: to be charged with the function of anticathexis.
Cyclic Adenosine 3′,5′-Monophosphate Response Element Binding Protein (CREB) and Related Transcription-Activating Deoxyribonucleic Acid-Binding Proteins*
Authors: TERRY E. MEYER, JOEL F. HABENER
Journal: Endocrine Reviews (1993)

THE COMPLEX metabolic activities of cells respond to environmental cues by sensing transmitter substances known as ligands or hormones. The mechanisms of such sensing involves the activation of signaling pathways resulting in changes in gene expression and cellular metabolism (1, 2). Small hydrophobic molecules such as steroid and thyroid hormones and retinoids readily traverse the plasma membrane of the cell and bind to and activate their cognate cytoplasmic or nuclear receptors (reviewed in Refs. 3–7). More complex ligands, however, such as peptide hormones, are unable to enter the cell directly and instead recognize and bind to receptors located on the surface of the cell. Thereby the receptor serves as the communicative link between the outside and inside of the cell. In addition to binding its specific ligand the receptor has the important function of activating signal transduction pathways by way of coupling to GTP-binding proteins (G proteins) (8, 9) or to autophosphorylate itself in response to conformational changes induced by the binding of ligand (10,11).