tbuckley/cabot-search huggingface dataset:
When should patients be held responsible for their lifestyle choices?
Authors: John Gillies, Mark Sheehan
Journal: BMJ (2006)

Many would argue, in a case like this,1 that individuals should be held accountable for the lifestyle choices that they make. People should be allowed to live their lives as they see fit, but when this goes against the generally received (medical) wisdom society is required to do only a limited amount to redress the consequences of those choices. So, when someone freely chooses to live life in a particular way, he, not society must shoulder the responsibility for those choices.2

This response is powerful, but two points can be made against its use …
Standards of Medical Care in Diabetes—2008
Authors: Irl B. Hirsch, Silvio E. Inzucchi, M. Sue Kirkman
Journal: Diabetes Care (2008)

We thank Dora, Kramer, and Canani (1) for their interest in the Standards of Medical Care in Diabetes—2008 (2) and their critique of the recommendations for aspirin for primary prevention of cardiovascular disease (CVD). The American Diabetes Association's “A”-level evidence also encompasses supportive evidence from a meta-analysis incorporating quality ratings. Supportive evidence can derive from studies in people without diabetes but at similar CVD risk.

The systematic review of evidence for the U.S. Preventive Services Task Force estimated that aspirin …
Clinical evaluation of lysuride in the management of hyperprolactinaemia.
Authors: P M Bouloux, G M Besser, A Grossman, P J Moult
Journal: BMJ (1987)

10% of maternal deaths, and the reported mortality is as high as 80% in some series.2Amniotic fluid embolism may occur after diagnostic amniocentesis, but this is uncommon.It is more likely to occur after hypertonic saline or dextrose is injected into the amniotic fluid.'In our patient exchange transfusion allowed rapid removal of red cell debris and haemoglobin from the circulation and provided red cells and clotting factors in fresh plasma.ABO incompatibility between fetal and maternal blood groups appears to have contributed to the severity ofour patient's condition; this was similar to the reaction that would be expected after transfusion of ABO incompatible blood.The complete disappearance of a high titre of anti-B immediately after the suspected embolism gives indirect evidence that the rapid deterioration was due to amniotic fluid embolism.Amniotic fluid is known to contain fetal blood group substances,4 and the findings above may be relevant to experiments in which amniotic fluid was injected into animals in an attempt to define the pathogenesis.5We believe that exchange transfusion helped to change the course of events and contributed to a successful outcome in this patient.
Physiological aspects of free-radical reactions.
Authors: I Yamazaki, M Tamura, R Nakajima, M Nakamura
Journal: Environmental Health Perspectives (1985)

Enzymes which catalyze the formation of free radicals in vitro will catalyze similar reactions in vivo. We believe that the formation of some kinds of free radicals has definite physiological meanings in metabolism. In this sense, the enzymes forming such free radicals are concluded to be in evolutionally advanced states. Elaborated structure and function of enzymes such as horseradish peroxidase and microsomal flavoproteins support the idea. Deleterious and side reactions caused by free radicals are assumed to be minimized in vivo by localizing the reactions, but this assumption should be verified by future studies.
Haem arginate in the treatment of acute hepatic porphyrias.
Authors: P Mustajoki, R Tenhunen, O Tokola, G Gothoni
Journal: BMJ (1986)

Industrial exposure to hydrogen cyanide: implications for treatment We had the opportunity of studying nine patients exposed to hydrogen cyanide in a single incident at an industrial plant and three other patients exposed in separate incidents.We believe that our observations have important implications for treatment of such patients.
Effects of atorvastatin on triglyceride-rich lipoproteins, low-density lipoprotein subclass, and C-reactive protein in hemodialysis patients
Authors: Ayako Ikejiri, Tsutomu Hirano, Satoru Murayama, Gen Yoshino, Natsuko Gushiken, Toru Hyodo, Takayasu Taira, Mitsuru Adachi
Journal: Metabolism (2004)
[717] ENDOTHELIAL FUNCTION IN NON-DIABETES SUBJECTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: M. lablkowski, J. Bialkowska, E. Szymanska-Grabarczyk, L. Czupryniak, M. Saryusz-Wolska, M. Pawlowski, A. Borkowska, P. Grzelak, L. Stefanczyk, A. Omulecka, J. Loba
Journal: Journal of Hepatology (2007)
EFFECTS OF METHIONINE AND HYDROXYCHLOROQUINE IN SCHIZOPHRENIA
Authors: GEORGE G. HAYDU, ANDREAS DHRYMIOTIS, CHARLES KORENYI, LEONTINE GOLDSCHMIDT
Journal: American Journal of Psychiatry (1965)

Two matching groups of schizophrenic patients refractory to conventional therapies were given methionine and hydroxychloroquine, respectively, following two base periods. Significant differences were observed in improvements and release rates and in the Standardized Affect Conveying Test. The methionine group showed exacerbation of symptomatology, while the hydroxychloroquine group showed amelioration of symptoms. The eosinophils and lymphocytes showed downward trend in the methionine group and so did the skin reactivity to intradermal injections. These results support the hypothesis that the schizophrenic process is exacerbated by increased effort readiness without discharge, as enhanced by methionine administration. The significant ameliorating effect of hydroxychloroquine is offered as a tool for therapeutic studies.
Medical News: Opportunities and Dangers
Authors: Alfred Soffer
Journal: JAMA (1986)

Science writing is a new discipline and one worthy of respect. It is becoming one of the most important methods of communication to both physicians and laymen. However, this imposes a responsibility on reporters to be aware of the deficiencies in the medical scientific community so that as science writers they are not misguided in the exercise of their profession. A large proportion of medical news aimed at the physician population is a direct result of the science writer's tendency to worship the god of speedy communication. The current fetish is to honor word about the<i>newest</i>drug, the<i>latest</i>device, the most<i>recent</i>transplant experiment. This phenomenon is a tribal practice that has deep roots in journalism. Only recently has there been an awareness that developments in medical science do not have to be covered in the same manner that one would report, for example, a four-alarm fire on
Diabetes poorly controlled by sulphonylureas.
Authors: T. D. Hockaday
Journal: BMJ (1988)

cases diagnosis was established on finding the pathogen in the liquid of bronchoalveolar lavage.Except in the patient who was already known to be seropositive for HIV, diagnosis was delayed and bronchoscopy was performed only when the clinical and radiological findings showed deterioration despite conventional antimicrobial treatment.In our region 15% of patients with AIDS are over 60 because of the high prevalence of the disease (129 cases per million inhabitants) and the mean age of the population (27% over 60).P canrnii pneumonia is the most common opportunistic infection in patients with AIDS.We agree with Dr Hargreaves and colleagues that P cannii pneumonia should be systematically considered in elderly patients with atypical, unresponsive chest infection.
Abstract 170: Combined mRNA and miRNA profiles in lung cancer cell lines as a tool to screen the targets contributes to cisplatin resistance
Authors: Yunguang Sun, Siyuan Zheng, Zhongming Zhao, Bo Lu
Journal: Cancer Research (2011)

Abstract microRNAs (miRNAs) are small RNAs average only 22 nucleotides long. miRNA signatures have been associated with histopathological and clinical features, suggesting a potential role of these molecules as prognostic and predictive markers. In this study, we generated a cisplatin resistance cell line. We profiled miRNA and mRNA expression in this cisplatin resistant cells and its parental cells using Exqon miRNA array platform and Affymetrix 1.0 ST array respectively. In order to identify functional regulatory gene-miRNA pairs in cisplatin resistance, we constructed a deregulated miRNA-gene network by incorporating miRNA-target genes information from TargetScan. The resulting miRNA-gene deregulation network consists of 72 genes and 27 miRNAs. 30 genes were up regulated and 42 were down regulated. Of the miRNAs, 26 were down regulated and 1 was up regulated. The network was further refined by retaining the negative correlated pairs considering that miRNAs predominantly decrease their target mRNA levels. We found several members of has-let-7 family were present in the network. IGF pathway gene, IGF2BP1, was also an important node. In our previous work, this pathway was identified as a promising target for cisplatin resistance treatment. Our results show that the has-let-7 miRNA family and IGF pathway genes may play important roles in cisplatin resistance. Exploration of the deregulation network can potentially provide more insights to the identification of candidate targets. Our approach also demonstrates the value of systems biology in the analysis of genomic data. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 170. doi:10.1158/1538-7445.AM2011-170
Anaplastic large cell Ki‐1 lymphoma involving bone marrow: Marrow findings and association with reactive hemophagocytosis
Authors: K. F. Wong, J. K. C. Chan, C. S. Ng, Y. C. Chu, P. W. Y. Lam, H. L. Yuen
Journal: American Journal of Hematology (1991)

Abstract This report describes the bone marrow findings in four patients whose marrow was involved by anaplastic large‐cell Ki‐1 lymphoma, an uncommon event in this type of lymphoma. In the marrow aspirate smears, the involvement was subtle, and was in the form of isolated large cells with irregular nuclear configuration, coarse chromatin, prominent nucleoli, and basophilic cytoplasm which might be vacuolated. One case showed paradoxically massive involvement in the trephine biopsy taken from the same site as the marrow aspirate. Reactive histiocytic proliferation with hemophagocytosis was also present. Since marrow aspirate or biopsy may be the first pathologic specimen examined in patients having anaplastic large‐cell Ki‐1 Iymphoma, it is important to be able to recognize the small population of neoplastic cells, which should lead to prompt treatment or further investigations as deemed necessary.
Preventing the Heterosexual Spread of AIDS-Reply
Authors: Norman Hearst
Journal: JAMA (1988)

<h3>In Reply.—</h3> We thank the authors of the above letters for their thoughtful and constructive comments. In response to Drs Padian and Francis, we want to stress our strong support for the use of condoms as a strategy to prevent AIDS. Educating patients about the importance of choosing their sexual partners carefully is not in conflict with a "blanket recommendation of condoms and nonoxynol 9." It also is not in conflict with advice on reducing the number of partners; to the contrary, as we noted in the article, an individual who has a large number of partners is less likely to be able to judge their HIV risk status accurately. We believe, in fact, that the ideas in our article will contribute to a likely future trend toward longer courtships and more monogamous life-styles. The case described by Dr Schulman illustrates how difficult it can be to avoid high-risk partners,
GIFT4-augmented B cells for melanoma immunotherapy
Authors: Jiusheng Deng, Andrea Pennati, Shala Yuan, Ragini Kudchadkar, David Lawson, Jacques Galipeau
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Melanoma is the most dangerous type of skin cancer and one of the fastest growing cancers in the USA. Immunotherapy, by enhancing patient's immune system, has become an attractive approach for melanoma treatment due to the rapid drug resistance to chemotherapy. B cells are a
Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype.
Authors: B Beutler, V Tkacenko, I Milsark, N Krochin, A Cerami
Journal: The Journal of Experimental Medicine (1986)

IFN-gamma permits the endotoxin-induced production of cachectin by C3H/HeJ (endotoxin resistant) macrophages, apparently by facilitating endotoxin-induced cachectin biosynthesis at both transcriptional and posttranscriptional levels. IFN-gamma cannot induce cachectin biosynthesis by itself, nor does it markedly enhance cachectin production by endotoxin-induced peritoneal macrophages obtained from endotoxin-responsive mice. Elucidation of the precise mechanism through which IFN-gamma influences cachectin biosynthesis may permit a better understanding of the molecular events that follow endotoxin-induced activation of macrophages. Moreover, the permissive effect of IFN-gamma on cachectin biosynthesis might elicit enhanced endotoxin sensitivity in vivo.
Neuroendocrine and Endocrine Pathways of Obesity
Authors: Joel K. Elmquist, Philipp E. Scherer
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What to Do When Zidovudine Fails
Authors: Michael S. Saag
Journal: New England Journal of Medicine (1994)

For many clinicians providing care for patients infected with the human immunodeficiency virus (HIV), their mood with regard to the use of antiretroviral therapy reflects the opening of Samuel Beckett's Waiting for Godot: “Nothing to be done.” The results of several recently completed clinical trials appear, at least on the surface, to conflict with previously established guidelines for the use of antiretroviral agents. To gain perspective on current therapeutic options, it is useful to consider the apparently contradictory data from clinical trials in a historical context as well as in the context of the pathogenesis of HIV.The original placebo-controlled . . .
Methodological reporting of randomized clinical trials in major gastroenterology and hepatology journals in 2006
Authors: Yu Bai, Jun Gao, Duo‐Wu Zou, Zhao‐Shen Li
Journal: Hepatology (2009)

To determine the current quality of reporting of randomized clinical trials (RCTs) in the field of gastroenterology and hepatology, we evaluated the methodological reporting of RCTs in six major gastroenterology and hepatology journals. The methodological quality, including generation of the allocation sequence, allocation concealment, double-blinding, and sample size calculation; number of patients; disease area; and funding source was also retrieved from each trial, and the relevant trials were identified by searching MEDLINE in 2006 using a highly sensitive search strategy. The status of reporting the methodological quality of RCTs was descriptively reported. One hundred five trials were included in the final analysis; of these, 81% (85/105) reported adequate generation of the allocation sequence, 61% (64/105) reported adequate allocation concealment, 51% (54/105) were double-blind, and 75% (79/105) reported adequate sample size calculation. The reported methodological quality greatly improved when compared with historical cohorts.This study shows that there was substantial improvement in the reported methodological quality in the major gastroenterology and hepatology journals, but this quality can be further improved.
Shelter for the twenty-first century.
Authors: J D Spengler
Journal: Environmental Health Perspectives (1990)

Housing for the twenty-first century will be shaped by the changes that are occurring in society. These include the demographics of the occupant, the products and materials used for construction and furnishing, and the basic use of the structure. An aging population will have different demands on design and function. The health concerns of an aging population encompass chronic degenerative diseases as well as injury. The lessons of the past must make us mindful that chronic, low-level exposures to substances can occur at home. Products and materials used in homes can release vapors that may affect immunologic and neurologic function. Manifestations of dysfunctions will be more important as our population ages and if there is a continued reliance on new chemical formulation for products used in homes and workplaces. The future portends changes in functional use of residences. Electronic communications and robotics will decentralize our work force. Manufacturing or office functions will occur at home. This will present new challenges for health and safety for both monitoring and prevention.
Use of SPECT/CT to Confirm Inconclusive Gastric Emptying Scintigraphy Results
Authors: Stephen Henrichon, Marc Seltzer, Alan Siegel
Journal: Clinical Nuclear Medicine (2015)

A 70-year-old man with cramping, abdominal pain, and diarrhea for 5 months after revision of a Nissen fundoplication underwent further evaluation with solid gastric emptying scintigraphy. On sequential planar images, we were uncertain if activity was present within the stomach or within loops of small bowel. SPECT/CT performed at 4 hours was used to localize the tracer, confirming its presence within the stomach.
Hazards of steroid therapy in hepatic failure
Authors: W.J. CUNLIFFE, J.L. BURTON, G. HOLTI, V. WRIGHT
Journal: British Journal of Dermatology (2006)

Three patients with extensive skin disease and liver failure are described. Two were treated with large amounts of topical corticosteroids and one with a small oral dose of betamethasone. The former two patients developed Addisonian crises when they failed to apply the topical steroids and all three patients developed aseptic necrosis of bone. This report emphasizes that the hazards of steroid therapy may be increased in patients with hepatic failure.
Tight Blood Glucose Control Pays Off in Reduced Cardiovascular Risk in Diabetes
Authors: M. J. Friedrich
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methotrexate in Reiter's disease.
Authors: E T Owen, M L Cohen
Journal: Annals of the Rheumatic Diseases (1979)

Three cases of severe Reiter9s disease were treated successfully with methotrexate after failure of conservative therapy, including systemic corticosteroids in 2 instances. The usefulness and potential hazards of such therapy are discussed, and some evidence that corticosteroids may aggravate the dermatological manifestations of Reiter9s disease is presented.
On Congenital Phimosis: With a Simple Operation for its Relief
Authors: F. Jordan
Journal: BMJ (1863)

out any associated fracture or displacement of the ribs.This fact is, unquestionably, to be explained by the greater elasticity of the thoracic wall in the child than in the adult, and the greater tendency to laceration of the lung-structure.The following case will, perhaps, best illustrate its truth.CASE.A boy, aged 7 years, when playing in the toad, was knocked down by the shaft of a cart; the wheel caught him by the left side of the lower part of his abdomen, and turned him round, stopping when just about to pass over the thorax.Intense dyspnoa and severe haemoptysis immediately re- sulted, and he was brought to Guy's.He was ad- mitted under the care of MIr.Birkett; and, as I hap- pened to be at the hospital at that time, I saw him, and noted the following facts.He was in bed, lying on his right side, half turned over on to his abdo- men, with his hips drawn up and flexed.There was intense dyspncea and cough, accompanied with hie- moptysis.He was quite collapsed, and nearly un- conscious ; and no indication of fractured ribs could be detected.He never rallied, but died two hours after the accident.