tbuckley/cabot-search huggingface dataset:
Of antibodies and their interaction
Authors: M van Kempen
Journal: Cardiovascular Research (2002)

We fully agree with Coppen's statement that misinter-Further we wished to stress that although we use an pretation of immunohistochemical staining patterns of Cx45-antibody that may crossreact with Cx43, we can connexins may become a pitfall for inexperienced sci-interprete the connexin-labeling of the antiCx45 to be true entists.We therefore regret that some phrases in the Cx45-labeling in areas where we see no Cx43 labeling Discussion section of our paper [1] may cause confusion.with a specific Cx43-antibody.We cannot and did not draw Firstly, however, we would like to emphasize that the such conclusions for cardiac regions where Cx43 is expression pattern of Cx45 in the central mouse sinus node expressed.[1] is in agreement with Coppen's data in the rabbit [2].We wish to set any misunderstanding straight on the specificity of the GP42 antibody raised against Cx45 [3].References In the Discussion section of our paper [1], we aimed at explaining that our commercial antibody (Alpha-diagnos-
Infection 57 Years after Plombage
Authors: Shimpei Gotoh, Naohiko Chohnabayashi
Journal: New England Journal of Medicine (2009)

An 86-year-old man had repeated episodes of septic shock due to MRSA pneumonia. In 1948, he had undergone extrapleural pneumonolysis (plombage) with polymethyl methacrylate (Lucite) balls to treat pulmonary tuberculosis.
Effect of Macrolides on<i>In Vivo</i>Ion Transport across Cystic Fibrosis Nasal Epithelium
Authors: Pierre M. Barker, Daniel J. Gillie, Michael S. Schechter, Bruce K. Rubin
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Fourteen- and 15-member macrolide antibiotics are under investigation as potential therapeutic agents for cystic fibrosis (CF). The nonantibiotic mechanisms of action of these compounds in CF are not understood. We used nasal potential difference (NPD) measurements to test the effect of macrolides on airway epithelial ion (chloride, sodium) transport of CF mice and humans. We tested clarithromycin and azithromycin in mice, and clarithromycin in patients with CF. Baseline and post-treatment NPD was measured in two strains (C57Bl6 and BalbC) of CF transmembrane regulator "knockout" and littermate control mice, and in DeltaF508/DeltaF508 mice. In addition, NPD was measured in 18 human subjects with CF (17 DeltaF-508/DeltaF-508 and 1 DeltaF-508/other) who were undergoing a 12-month, randomized, double-blind crossover study of the effects of clarithromycin on pulmonary outcome in CF. Neither clarithromycin nor azithromycin affected ion transport characteristics of normal or CF nasal epithelium in either mouse or humans. We conclude that the apparent beneficial effects of macrolides on pulmonary outcome in CF are not mediated by their modulation of ion transport.
Global Review of Diet and Cancer Links Available
Authors: Charles Marwick
Journal: JAMA (1997)

A MAJOR REPORT on the relationship between nutrition and the development of cancer concludes that 3 million to 4 million cases of cancer per year could be prevented by appropriate diet and such lifestyle changes as reducing tobacco and alcohol consumption. The 670-page report,<i>Food, Nutrition and the Preven-</i><i>tion of Cancer: A Global Perspective</i>, is the result of 3 years of work by a panel of more than 150 scientists who reviewed and evaluated 4500 research studies. The document was prepared with the support of the American Institute for Cancer Research, Washington, DC, and the World Cancer Research Fund, London, England. Both seek to increase knowledge about the role of nutrition in the prevention of cancer. The report is probably the most comprehensive review and evaluation of scientific evidence on diet and cancer since the National Academy of Sciences' 1982 report,<i>Diet, Nutrition and Cancer</i>. "We considered the published
Media Feeds Frenzy Over Shark Cartilage As Cancer Treatment
Authors: J. Mathews
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Media Feeds Frenzy Over Shark Cartilage As Cancer Treatment Get access James Mathews James Mathews Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 15, 4 August 1993, Pages 1190–1191, https://doi.org/10.1093/jnci/85.15.1190 Published: 04 August 1993
Modulation of T-cell responses to alloantigens by TR6/DcR3
Authors: Jun Zhang, Theodora W. Salcedo, Xiaochun Wan, Stephen Ullrich, Bugen Hu, Theresa Gregorio, Ping Feng, Shijie Qi, Huifang Chen, Yun Hee Cho, Yuling Li, Paul A. Moore, Jiangping Wu
Journal: Journal of Clinical Investigation (2001)

TR6 (DcR3) is a new member of the TNF receptor (TNFR) family that lacks a transmembrane domain in its sequence, indicating that it is a secreted molecule. TR6 can bind to FasL and prevent FasL-induced apoptosis; it can also associate with LIGHT, another TNF family member. The role of TR6 in immune responses was investigated in this study. According to flow cytometry, recombinant human TR6-Fc binds to human LIGHT expressed on 293 cells or on activated human T cells and competes with the LIGHT receptor TR2 for the binding to LIGHT on these cells. Human TR6 could cross-react with mouse LIGHT in immunoprecipitation. TR6-Fc also downregulates cytotoxic T lymphocyte activity in vitro and graft-versus-host responses in mice. Moreover, TR6-Fc modulates lymphokine production by alloantigen-stimulated mouse T cells. TR6-Fc ameliorated rejection response to mouse heart allograft. These results indicate that TR6 can dampen T-cell responses to alloantigens. Such regulatory effects of TR6 probably occur via interference with interaction between pairs of related TNF and TNFR family members, LIGHT/TR2 being one of the possible candidate pairs.
Instability of Ventilatory Control in Patients with Obstructive Sleep Apnea
Authors: DAVID W. HUDGEL, ELIZABETH A. GORDON, SITTHEP THANAKITCHARU, EUGENE N. BRUCE
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Because of the oscillatory pattern of upper airway resistance and breathing during sleep in patients with obstructive sleep apnea (OSA), we hypothesized that OSA patients have an underlying instability of ventilatory drive to inspiratory muscles. To assess the stability of ventilatory drive in OSA patients and controls, we used the pseudorandom binary stimulation (PRBS) test and examined the closed- and open-loop responses to hyperoxic hypercapnia. The closed-loop response is produced by interactions of dynamic gain in controller, plant, and ventilatory feedback. The open-loop response reflects controller dynamic gain or frequency-dependent chemosensitivity. As compared with 16 nonapneic, nonobese control subjects, a group of nine obese OSA patients had a higher peak response and a more rapid and irregular recovery phase of the closed-loop CO2 response in the PRBS test. The two groups had similar open-loop responses in the PRBS test, suggesting that central dynamic CO2 chemosensitivity was not abnormal in OSA. We conclude that the differences between OSA patients and controls in the closed-loop response in the PRBS test are not due to differences in dynamic controller gain, but are related to differences in dynamic plant gain and/or negative ventilatory feedback. In addition to OSA, obesity may affect these variables and may have been responsible for our findings.
Hypersensitivity reactions to paracetamol in children: a study of 25 cases
Authors: K. Boussetta, C. Ponvert, C. Karila, M. Le Bourgeois, J. de Blic, P. Scheinmann
Journal: Allergy (2005)

Allergic-like reactions to paracetamol (acetaminophen) are rare. Paracetamol allergic and nonallergic hypersensitivity (HS) has been diagnosed in a few patients with skin and/or respiratory symptoms, immediate and accelerated urticaria, and angioedema especially. Most patients with HS to paracetamol were also hypersensitive to anti-inflammatory drugs (i.e. acetylsalicylic acid, ASA), suggesting that their reactions resulted from a nonallergic HS. However, anaphylactic reactions, and potentially harmful toxidermias, such as acute generalized exanthematic pustulosis and toxic epidermal necrolysis, have been related to specific paracetamol allergic HS, with tolerance to anti-inflammatory drugs.We report the results of a study performed in 25 children with suspected paracetamol HS. Diagnosis of paracetamol HS was based on a suggestive clinical history and a positive response in an oral challenge (OC) test.Paracetamol HS was diagnosed in only one child (4%). In this child, a positive response to an OC with ASA diagnosed HS to anti-inflammatory drugs.Our results in children agree with those of the literature, showing that paracetamol HS is rare, and is associated with HS to anti-inflammatory drugs in most patients.
Cardiac mortality in β‐thalassemia major: resting but not dobutamine stress echocardiography predicts mortality among initially cardiac disease‐free patients in a prospective 12‐year study
Authors: George Hahalis, Alexandra Kourakli, Ioanna Gerasimidou, Andreas P. Kalogeropoulos, George Sitafidis, Urania Papageorgiou, Periklis Davlouros, Nikos Grapsas, Nicholas C. Zoumbos, Dimitrios Alexopoulos
Journal: European Journal of Heart Failure (2009)
Tin miners'granuloma
Authors: P.W. Bowers, D.J. Gould, A. Telfer Brunton, M. Hewitt
Journal: British Journal of Dermatology (1987)

Journal Article Tin miners'granuloma Get access P.W. Bowers, P.W. Bowers Royal Cornwall Hospital, Truro Search for other works by this author on: Oxford Academic Google Scholar D.J. Gould, D.J. Gould Royal Cornwall Hospital, Truro Search for other works by this author on: Oxford Academic Google Scholar A. Telfer Brunton, A. Telfer Brunton Royal Cornwall Hospital, Truro Search for other works by this author on: Oxford Academic Google Scholar M. Hewitt M. Hewitt Royal Cornwall Hospital, Truro Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Page 28, https://doi.org/10.1111/j.1365-2133.1987.tb12017.x Published: 01 June 1987
Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate.
Authors: L J O'Donnell, J Virjee, K W Heaton
Journal: BMJ (1990)

biopsy in our patients did not show evidence of Crohn's disease, but there was unequivocal evidence of Crohn's disease elsewhere.Furthermore, the failure of symptoms in patients who do not smoke to respond to treatment suggests peptic ulceration associated with Crohn's disease.Treatment with omeprazole led to prompt relief of symptoms and complete healing of ulceration, which was confirmed by endoscopy.Omeprazole is effective in resistant peptic ulcera- tion,' but there is only one report of its use in Crohn's disease.4A proton pump inhibitor, it is capable of maintaining high intragastric pH for long periods.Its effectiveness in our two patients suggests that duodenal ulceration in Crohn's disease is dependent on acid.If prolonged active ulceration can cause pyloric stenosis then intermittent omeprazole treatment might prevent this complication in patients with Crohn's disease.Our observations support the view that inhibition of acid production is more likely to heal duodenal ulceration associated with Crohn's disease than steroid treatment, which may lead to complications such as perforation or haemorrhage.I Wectcrman IT.Oral, oesophagcal and gastro-duodenal Crohn's disease.
Two-year follow-up of the RAVEL study: A randomized study with the sirolimus-eluting Bx VELOCITY stent in the treatment of patients with denovo native coronary artery lesions
Authors: Marie-Claude Morice, Patrick Serruys, Costantino Costantini, Egon Wuelfert, William Wijns, Jean Fajadet, Antonio Columbo, Guilio Guagliumi, Ferenc Molnar, Ernesto Ban Hayashi, Jose Eduardo M. Sousa, Marco Perin
Journal: Journal of the American College of Cardiology (2003)
Iodine-123 phenylpentadecanoic acid and single photon emission computed tomography in identifying left ventricular regional metabolic abnormalities in patients with coronary heart disease: Comparison with thallium-201 myocardial tomography
Authors: Christopher L. Hansen, James R. Corbett, John J. Pippin, Donald E. Jansen, Padmaker V. Kulkarni, Valentina Ugolini, Eugene Henderson, Marvin Akers, L.Maximilian Buja, Robert W. Parkey, James T. Willerson
Journal: Journal of the American College of Cardiology (1988)
UK report supports EU proposals to test drugs in children
Authors: Susan Mayor
Journal: BMJ (2006)

Half of the drugs used in the European Union to treat children and 90% of drugs given to newborn babies have never been tested or authorised for use in these age groups, warns a new UK report. The report supports new European proposals to test drugs in children.

The report, published last week, supports the European Commission's proposal to introduce a common EU-wide procedure for testing and approving drugs for use in children and incentives to encourage manufacturers to develop drugs specifically for paediatric use.

The subcommittee of the House of Lords European Union Committee that developed the report said: “It is high time this was done, and the framework proposed seems right.”

However, …
Propylthiouracil Levels in Hyperthyroid Patients Unresponsive to Large Doses
Authors: DAVID S. COOPER
Journal: Annals of Internal Medicine (1985)

Nine patients with hyperthyroidism due to Graves' disease did not respond to therapy with very large doses (800 to 2000 mg/d) of propylthiouracil. In eight patients, studies showed propylthiouracil was absorbed and metabolized normally. Five patients had no detectable propylthiouracil in their serum 2 to 3 hours after supposedly taking their medication at home, and three patients had markedly abnormal results of perchlorate discharge tests after receiving propylthiouracil under supervision. After evaluation, noncompliance was thought to be the reason for treatment failure in six of the nine patients; one patient was possibly resistant. In two patients, data were insufficient, although intermittent noncompliance could not be ruled out. Among patients who respond poorly to propylthiouracil therapy, noncompliance is the most likely reason. In such patients, methimazole should be substituted for continued massive doses of propylthiouracil.
Comparative Cost-effectiveness of Robot-assisted and Standard Laparoscopic Prostatectomy as Alternatives to Open Radical Prostatectomy for Treatment of Men with Localised Prostate Cancer: A Health Technology Assessment from the Perspective of the UK National Health Service
Authors: Andrew Close, Clare Robertson, Stephen Rushton, Mark Shirley, Luke Vale, Craig Ramsay, Robert Pickard
Journal: European Urology (2013)
Positive mental health-related impacts of the SARS epidemic on the general public in Hong Kong and their associations with other negative impacts
Authors: J LAU, X YANG, H TSUI, E PANG, Y WING
Journal: Journal of Infection (2005)

To investigate 2 positive impacts (better family/social support and lifestyle changes) and their associations with other negative impacts.A telephone survey using random telephone numbers and a structured questionnaire was conducted in Hong Kong general population. Eight hundred and eighteen Hong Kong residents of age 18-60 years completed the interview (response rate: 65%) at around end of June 2003, the early ending phase of the epidemic.Over 60% of the respondents stated that they cared more about the family members' feelings; about 30%-40% stated that they found their friends, their family members more supportive or having more sharing with others when not feeling happy; only a few percent felt the opposite. Further, about 2/3 of the respondents paid more attention to their mental health. About 35%-40% took more time to rest, for relaxation or doing exercise. These items were, in general, negatively associated with post-traumatic stress, perception of stress and other perceptions that were related to SARS.SARS have brought some positive impacts on social/family support, mental health awareness and lifestyle changes. These positive impacts were associated with other relevant negative impacts and might be important cushions of the negative impact.
Tarsal-tunnel syndrome is rheumatoid arthritis.
Authors: E H Chater
Journal: BMJ (1970)

well, flatly denied that a patient with a par- ticular condition was in the hospital.The administrator, however, after several calls, agreed that such a patient was there but that premature publicity might cause her anxiety and hazard her health.I therefore agreed not to write anything.When I challenged the doctor with this information he said, "I just wanted to throw you off the scent."This sort of experience makes the plea that journalists should treat doctors more gently seem rather hollow.Doctors with ex- perience of reputable journalists will know that reporters frequently are asked and agree to keep confidence about something, even if it is only to preserve a doctor's identity to protect him from charges of advertising.But if a doctor has a grievance about in- accurate reporting or unethical behaviour by reporters he has the remedy in his own hands.A complaint to the newspaper or perhaps to the Press Council can have a very sobering effect on the journalist involved.It is significant that the Press Council confirms that complaints from doctors about medical matters are extremely rare.-Iam, etc.,
The Surgical Learning Curve for Prostate Cancer Control After Radical Prostatectomy
Authors: A. J. Vickers, F. J. Bianco, A. M. Serio, J. A. Eastham, D. Schrag, E. A. Klein, A. M. Reuther, M. W. Kattan, J. E. Pontes, P. T. Scardino
Journal: JNCI Journal of the National Cancer Institute (2007)

The learning curve for surgery—i.e., improvement in surgical outcomes with increasing surgeon experience—remains primarily a theoretical concept; actual curves based on surgical outcome data are rarely presented. We analyzed the surgical learning curve for prostate cancer recurrence after radical prostatectomy. The study cohort included 7765 prostate cancer patients who were treated with radical prostatectomy by one of 72 surgeons at four major US academic medical centers between 1987 and 2003. For each patient, surgeon experience was coded as the total number of radical prostatectomies performed by the surgeon before the patient's operation. Multivariable survival–time regression models were used to evaluate the association between surgeon experience and prostate cancer recurrence, defined as a serum prostate-specific antigen (PSA) of more than 0.4 ng/mL followed by a subsequent higher PSA level (i.e., biochemical recurrence), with adjustment for established clinical and tumor characteristics. All P values are two-sided. The learning curve for prostate cancer recurrence after radical prostatectomy was steep and did not start to plateau until a surgeon had completed approximately 250 prior operations. The predicted probabilities of recurrence at 5 years were 17.9% (95% confidence interval [CI] = 12.1% to 25.6%) for patients treated by surgeons with 10 prior operations and 10.7% (95% CI = 7.1% to 15.9%) for patients treated by surgeons with 250 prior operations (difference = 7.2%, 95% CI = 4.6% to 10.1%; P <.001). This finding was robust to sensitivity analysis; in particular, the results were unaffected if we restricted the sample to patients treated after 1995, when stage migration related to the advent of PSA screening appeared largely complete. As a surgeon's experience increases, cancer control after radical prostatectomy improves, presumably because of improved surgical technique. Further research is needed to examine the specific techniques used by experienced surgeons that are associated with improved outcomes.
Hepatitis B Vaccine for Medical Students-Reply
Authors: A. Thomas McRae
Journal: JAMA (1996)

<h3>In Reply.</h3> —We appreciate the interest and input from Dr Wallin and colleagues regarding our Commentary on the need for more rigorous standards in the vaccination practices of medical schools for their medical students against HBV. It is unfortunate that many medical students are still not vaccinated against HBV, a potentially lethal pathogen to which they are repeatedly exposed during their clinical years. An earlier draft of our work made it more clear that medical students are not employees and, therefore, cannot be under OSHA's jurisdiction. Our Commentary sought to highlight the OSHA standard on blood-borne pathogens, which rightfully provides employees with the necessary education and vaccination against HBV, as a model for medical schools to emulate in their own vaccination practices for their students. Wallin et al also note that universal childhood HBV vaccination practices promulgated by the Advisory Committee on Immunization Practices and the American Academy of Pediatrics
Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels.
Authors: D D Bikle, B P Halloran, E Gee, E Ryzen, J G Haddad
Journal: Journal of Clinical Investigation (1986)

We determined the free fraction of 25-dihydroxyvitamin D (25OHD) in the serum of subjects with clinical evidence of liver disease and correlated these measurements to the levels of vitamin D binding protein and albumin. These subjects when compared to normal individuals had lower total 25OHD levels, higher percent free 25OHD levels, but equivalent free 25OHD levels. These subjects also had reduced vitamin D binding protein and albumin concentrations. The total concentration of 25OHD correlated positively with both vitamin D binding protein and albumin, whereas the percent free 25OHD correlated negatively with vitamin D binding protein and albumin. The free 25OHD levels did not correlate with either vitamin D binding protein or albumin. We conclude that total vitamin D metabolite measurements may be misleading in the evaluation of the vitamin D status of patients with liver disease, and recommend that free 25OHD levels also be determined before making a diagnosis of vitamin D deficiency.
MISTAKES IN TERMINOLOGY
Authors: Howard Fox
Journal: JAMA (1926)

<h3>To the Editor:</h3> —There can be no doubt as to the high quality of the scientific work of the medical profession in this country. The same cannot be said of the standard of scholarship as shown by many of our medical publications. Mistakes in the simplest Latin terminology are constantly seen which would never be made by those who had been educated in Europe. One of the most frequent errors, which has lately been brought to my attention, occurs in connection with the words labium majus and labium minus, which have been frequently misspelled in excellent publications appearing in high class journals. Examples of such errors include "the left labium minorum," "the whole of the right labiae majorae and minorae" and the "right labia majora." One author has spoken in the same sentence of the "labiae" and the "labia." The majority of physicians seem to have forgotten that majus is