tbuckley/cabot-search huggingface dataset:
A novel tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphism associated with asthma in Australian women
Authors: F Lose
Journal: Thorax (2005)

<b>Background:</b> Airway remodelling is a characteristic feature of chronic asthma and there is evidence that an airway imbalance between levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) is associated with airway remodelling. On this basis, we hypothesised that polymorphisms in the MMP-9 and TIMP-1 genes were associated with the disease process. <b>Methods:</b> A number of MMP-9 and TIMP-1 gene polymorphisms were examined in an adult white Australian population of mild (n = 259), moderate (n = 213) and severe (n = 71) asthmatics and non-asthmatic controls (n = 406) using PCR-RFLP and PCR-SSCP analyses. <b>Results:</b> MMP-9 –1562C&gt;T and 836G&gt;A (Arg279Gln) were not associated with asthma (p⩾0.15) or asthma severity (p⩾0.13), and TIMP-1 434T&gt;C (Phe124Phe) was not associated with asthma in women (p = 0.094) or men (p = 0.207). In this population, MMP-9 −861C&gt;T and TIMP-1 323C&gt;T (Pro87Pro) were not informative (with minor allele frequencies of &lt;1%), and MMP-9 –1702T&gt;A and TIMP-1 595C&gt;T (Ser178Phe) were not detectable. However, a novel polymorphism was detected in the TIMP-1 gene 536C&gt;T (Ile158Ile) which was significantly associated with asthma in women (p = 0.011; OR = 5.54, 95% CI 1.66 to 34.4) but not in men (p = 1.0). 536C&gt;T was found to be in linkage disequilibrium with 434T&gt;C, and haplotype analysis supported an association with asthma (p = 0.014). <b>Conclusions:</b> This is the first reported association between a polymorphism in the TIMP-1 gene and asthma, and supports the hypothesis that the protease/antiprotease balance has an important role in this common disease.
Managed Care, Mental Health, and the Marketplace-Reply
Authors: Barry Nurcombe
Journal: JAMA (1994)

<h3>In Reply.</h3> —As is typical of for-profit managed care, Dr Cann dismisses the profit motive in the first paragraph and then hides within the citadel of managed care principles for the remainder of his letter. Our Commentary did not attack managed care principles, and we do not advocate wasting resources for any reason, including physician convenience or excessive profit. We fully support thoughtful efforts at continuous improvement of quality and efficiency. With little mention of quality or research, Cann is ready to halve the number of psychotherapy sessions and decrease dramatically inpatient treatment and is at ease with economic credentialing. On what basis are these decisions being made? Patient satisfaction is a valuable driving force for productive change and certainly is essential to marketing, but it is not sufficient to justify curtailing services. Who are the satisfied providers? Are they independent, certified by academic boards, or credentialed by for-profit companies?
Outreach Education Among Intravenous Drug Users: Use CHOWs
Authors: John Newmeyer
Journal: JAMA (1989)

<h3>To the Editor.—</h3> "Treatment is prevention" in the area of acquired immunodeficiency syndrome and intravenous drug users (IVDUs). However, treatment suffers from three disadvantages: it is expensive, a long lead time is needed to gear up a treatment program, and only about half of IVDUs will enter treatment even if offered their choice among cost-free alternatives. These disadvantages have impelled human immunodeficiency virus (HIV) prevention workers in many localities to develop outreach education programs as a cost-effective supplement to treatment. It is instructive to compare costs and benefits of methadone maintenance and outreach risk-reduction education in a city hard hit by HIV. There are about 13 000 heterosexual IVDUs in San Francisco, Calif, of whom about 17% are currently HIV infected.<sup>1</sup>Survey research conducted in 1985 and 1986 showed that more than 80% of IVDUs reported recent sharing of injection equipment.<sup>2</sup>Arguably, this population in a few years
Effect of tetraethylammonium, 4-aminopyridine, cesium and magnesium on slow responses in the guinea pig papillary muscle
Authors: M SEBESZTA, E CORABOEUF, E DEROUBAIX, M Le FLOCH
Journal: Cardiovascular Research (1981)

Having inactivated the sodium conductance by K-rich media, propagated slow responses were triggered by local electrical stimulation after addition of catecholamines. We determined the smallest noradrenaline concentration eliciting slow responses (noradrenaline threshold) and it was found to be 1.04 X 10(-6) mol . litre-1 +/- 0.25. The rate of rise and the amplitude of cardiac slow responses increase with the external concentration in calcium, however their development is also influenced by altering potassium conductances. Substances inhibiting gK: tetraetylammonium, 4-aminopyridine and cesium increased the maximal rate of rise and the duration of slow responses and except for the latter compound, decreased the noradrenaline threshold. On the other hand Mg ions exerted an inhibitory effect on slow responses since they markedly decreased the maximal rate of depolarisation and increased the noradrenaline threshold in spite of a very small increase in the duration of slow responses. The effect of Mg ions can be explained by an inhibition of the slow inward current.
Morphologic and functional characterization of caveolae in rat liver hepatocytes
Authors: Maria Calvo, Francesc Tebar, Carmen Lopez-Iglesias, Carlos Enrich
Journal: Hepatology (2001)

Caveolae are small pits on the plasma membrane found in several, if not all, differentiated cells. They are involved in potocytosis, endocytosis, transcytosis, membrane trafficking, and signal transduction. Although caveolin has recently been identified in subcellular fractions from rat liver there is no clear-cut morphologic evidence for the presence of prototypical caveolae on the surface of hepatocytes. In this study the presence of caveolae at the cell surface of hepatocytes was directly shown by rapid-freeze, deep-etching electron microscopy. Moreover, combined deep-etching and immunogold techniques revealed caveolin in caveolae of the dorsal membrane of primary culture hepatocytes. Using reagents that perturb membrane cholesterol and interfere with endocytosis through the caveolae, a caveolae-dependent internalization of cholera toxin B and retinol-binding protein by hepatocytes in primary culture was shown. Finally, immunocytochemical analysis of caveolin in nonparenchymal cells of the rat liver showed its presence in Kupffer and stellate cells, however no caveolin could be detected in endothelial cells.
Blocking IL-1 in systemic inflammation
Authors: Charles A. Dinarello
Journal: The Journal of Experimental Medicine (2005)

A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.
Isolation of uncommon respiratory and enteric Acinetobacter baumannii from hematologic patients and emergence of tigecycline-resistance
Authors: Vincenzo Savini, Chiara Catavitello, Franca Pompetti, Marzia Talia, Lara Costanzi, Andrea Balbinot, Fabio Febbo, Silvia Di Zacomo, Francesca Esattore, Domenico D'Antonio
Journal: Journal of Infection (2008)
A PURE STRAIN OF THYROID CELLS AND ITS CHARACTERISTICS
Authors: Albert H. Ebeling
Journal: The Journal of Experimental Medicine (1925)

1. A pure strain of thyroid epithelium was isolated and maintained in active condition for 7 months. At the end of the experiment, the rate of cell multiplication was as great as at its beginning. 2. The thyroid cells grew at the surface of the coagulum as pavement epithelium, and within the coagulum as a glandular structure. 3. The cells did not dedifferentiate, and the lumen of the acini in cultures from a strain over 4 months old contained colloid secretion similar morphologically to that from a freshly extirpated thyroid gland.
SAT0301 Prevalence of Psoriatic Arthritis in a Large Cohort of Brazilian Psoriatic Patients
Authors: R. Ranza, C. Goldenstein-Schainberg, S. Carneiro, G. Martins, J. J. Rodrigues, R. Romiti, T. M. Bitar Barros, J. Carneiro, A. L. Sampaio, R. Grynspan, J. Markus, R. Melo Costa Pinto
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Psoriatic Arthritis (PsA) may affect up to 40% of patients with psoriasis (PsO). Usually PsO precedes PsA for many years, though PsA is frequently not identified in dermatology clinics. Diagnosis of PsA is based on clinical recognition of arthritis, enthesitis and spondylitis. <h3>Objectives</h3> To determine the prevalence of PsA in a large cohort of Brazilian patients with PsO attending different dermatology reference centers. <h3>Methods</h3> A multicenter study was conducted in four universitary dermatology clinics, from January to March 2011. In each center, consecutive patients with a confirmed diagnosis of PsO were evaluated by a rheumatologist. Following detailed musculoskeletal anamnesis and physical examination, subjects were classified as having: isolated PsO, osteoarthritis (OA) and/or chronic myofascial pain (CMP) syndrome, PsA (CASPAR criteria<sup>1</sup>). Laboratory and x-Ray tests were performed, as needed, according to the rheumatologist clinical judgment. <h3>Results</h3> A total of 524 PsO patients were evaluated. Mean age was 48.5 ± 14.5yrs, 50% were females and PsO mean duration was 15.4±11.7yrs. The vast majority (79%) had plaque psoriasis and 57.8% required systemic treatment. Isolated PsO was the diagnosis in 45% of patients, whereas 22% manifested OA and/or CMP. A definitive diagnosis of PsA was documented in 175 patients (33%), of which 49% were newly identified by the rheumatologist. Lab and/or x-Ray tests were necessary for the diagnosis of PsA in 42/175 individuals. In 38/175 subjects, PsA was associated with OA and/or CMP. Most PsA patients (72%) had peripheral, 11% axial and 17% both peripheral and axial involvement. Dactilitis occurred in 20% and clinical enthesitis in 30%. Remarkably, PsA patients were older (51 vs 47yrs, p 0.015), had more nail involvement (59 vs 47%, p 0.008), were less likely to be on any systemic treatment (42 vs 56%, p 0.01) and were more frequently using biologic drugs (21 vs 5%, p&gt;0.001) compared with those without PsA. <h3>Conclusions</h3> We have demonstrated a similar worldwide prevalence of 1/3 of PsA among Brazilian patients with PsO. The identification of new PsA diagnosis by a rheumatologist in half of patients, previously unrecognized at the dermatology setting, points out to the need for shared care between dermatologists and rheumatologists in order to establish earlier PsA diagnosis and adequate multidisciplinary management. <h3>References</h3> Taylor W, Gladman D, Helliwell P et al. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum 2006; 54:2665–73 <h3>Disclosure of Interest</h3> None Declared
Abstract P16: The Decreases of Left Ventricle Volume and Area During VF Affect Resuscitation Outcomes
Authors: Jun Hwi Cho, Giuseppe Ristagno, Tao Yu, Yongqin Li, Shijie Sun, Carlos Castillo, Max Harry Weil, Wanchun Tang
Journal: Circulation (2008)

Introduction: Dynamic changes in dimensions of left ventricle (LV) during cardiac arrest might influence the efficacy of CPR. However, the relationships between change in LV dimensions during cardiac arrest and CPR hemodynamic and outcomes remain to be studied. In the present study, we investigated changes of left ventricular volume and area during prolonged untreated ventricular fibrillation (VF) and related those change to coronary perfusion pressure (CPP) during CPR and resuscitation outcomes. Hypothesis: Decreased LV volume and area during prolonged VF interval would yield low CPP and poor resuscitation outcomes. Methods: In 12 domestic male pigs weighing 40±3 kg, VF was electrically induced and untreated for 15 min. CPR was performed for a 5 min interval prior to defibrillation. CPR was continued until return of spontaneous circulation (ROSC) or for a max of 15 minutes. Diastolic aortic and right atrial pressures were measured and CPP was calculated. LV dimensions were continuously assessed by echocardiographic measurement during the 15 minutes of untreated VF. Results: 6 animals were successfully resuscitated. During the 15 minute interval of VF, LV area and volume reduced in all the animals. In animals that were not resuscitated LV dimensions were significantly lower compared to those in resuscitated animals (p=0.01). These differences were observed after 10 minutes of untreated VF. The animals with greater reduction in LV dimension during VF, achieved significantly lower CPP during CPR in contrast to animals with larger LV during VF (Table ). Conclusion: Greater decrease in LV volume and area during cardiac arrest are associated with low CPP during CPR and poor resuscitation outcome. LV dimensions prior to start CPR might therefore affect the effectiveness of resuscitation interventions.
Polypharmacy in Skilled-Nursing Facilities
Authors: Mark H. Beers
Journal: Annals of Internal Medicine (1993)

Letters15 April 1993Polypharmacy in Skilled-Nursing FacilitiesMark H. Beers, MDMark H. Beers, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-8-199304150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Slater for his comments and congratulate him on the successes he has had in improving the quality of prescribing in nursing homes. We too are looking at interventions to improve prescribing.As Dr. Terplan notes, our study [1] did not examine outcomes of inappropriate drug use, although we soon plan to report data on selected outcomes. Using explicit criteria without clinical outcomes, however, does not distort the results of evaluating prescribing quality. It may be, as he suggests, that many of these medications were not needed, but we did not study the indications for therapy. ...References1. Beers MH, Ouslander JG, Fingold SF, Morgenstern H, Reuben DB, Rogers W, et al. Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med. 1992; 117:684-9. Google Scholar2. Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC. Explicit criteria for determining inappropriate medication use in nursing home residents. Arch Intern Med. 1991; 151:1825-32. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1993Volume 118, Issue 8Page: 649-651KeywordsAntidepressantsComputersDrugsForecastingHealth care qualityNSAIDsNursing homesResearch design ePublished: 15 August 2000 Issue Published: 15 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Myth of Heterosexual AIDS: A Review-Reply
Authors: Virginia M. Anderson
Journal: JAMA (1990)

<h3>In Reply.—</h3> I regret any unconscious, homophobic, or racist inferences in my review of Michael Fumento's book<i>The Myth of Heterosexual AIDS</i>. Human immunodeficiency virus has no sexual or skin color preference. The acquired immunodeficiency scourge affects all of us. Unfortunately, the underclass, already burdened by poverty, homelessness, and limited education and communication skills, in addition to inadequate access to health care, now must prepare to bear the brunt of human immunodeficiency virus infection. Acquired immunodeficiency syndrome will bring death and destruction to neighborhoods and families. Crack houses have replaced gay bathhouses as havens of sexual promiscuity and human immunodeficiency virus infection. Many unsuspecting and loving women are infected and infect their infants. Others are date raped. Denial, isolation, and a male-dominated sexual value system make women vulnerable. The intense campaigns for safe sex that protected the gay community from new infection are lost on the impoverished and addicted. Public
The Gift Relationship: From Human Blood to Social Policy
Authors: Frances K. Widmann
Journal: JAMA (1971)

Professor Titmuss, an eminent English social theorist, believes that man is inherently altruistic and that the duty of government is to create that social and economic climate which best channels man's drive to work together for the common good. In support of this belief, he has written a book about the procurement, distribution, and transfusion of human blood, a medical topic which he employs as an illustrative social and economic microcosm. The conclusion he reaches is foregone: "The voluntary socialized system in Britain is economically, professionally, administratively and qualitatively more efficient than the mixed, commercialized, and individualistic American system" (Titmuss, R.M: "Why Give to Strangers?"<i>Lancet</i><b>1</b>:123-125, 1971). As the book was written with a bias, so will it be read with bias. My own bias is that of an American and a blood-banker. I am only too conscious of many deficiencies in the American complex of arrangements—it isn't
Pk 11195 Aggravates 3,5–Diethoxycarbonyl–1,4–Dihydrocollidine–Induced Hepatic Porphyria in Rats
Authors: O Fonia, R Weizman, R Coleman, E Kaganovskaya, M Gavish
Journal: Hepatology (1996)

There is evidence to suggest that peripheral–type benzodiazepine receptors (PBR) are involved in porphyrin transport during erythroid differentiation, and it is possible that these receptors have an important role in heme biosynthesis. We examined the biochemical and ultrastructural alterations in rat liver following experimentally induced acute hepatic porphyria, as well as the effects of the administration of a selective PBR ligand, PK 11195. The most severe pathological conditions were found in rats that received a combined treatment of the porphyrinogenic agent 3,5–diethoxycarbonyl–1,4–dihydrocollidine (DDC) and PK 11195. Transmission electron microscopy showed a correlation between the ultrastructural pathology of the liver, the total porphyrin levels in urine and liver, and the porphobilinogen levels in urine. Hepatocytes in this acute porphyria showed the development of large secondary lysosomes containing crystalline aggregates of protoporphyrin. Bile canaliculi were grossly enlarged, contained aggregates of protoporphyrin crystals, and showed the presence of bile thrombi. In addition, prominent bundles of collagen fibers (fibrosis) were commonly found in livers of rats that had been treated with DDC or DDC and PK 11195. We conclude that the administration of PK 11195 to porphyric rats aggravates porphyrin accumulation and cellular damage in the liver. Perhaps this evidence suggests that PK 11195 blocks the binding of protoporphyrin IX to PBR, thus elevating the content of protoporphyrin IX in liver.
Hypertrophic Pulmonary Osteoarthropathy as a Paraneoplastic Manifestation of Lung Cancer
Authors: Takeo Ito, Koichi Goto, Kiyotaka Yoh, Seiji Niho, Hironobu Ohmatsu, Kaoru Kubota, Kanji Nagai, Eishi Miyazaki, Toshihide Kumamoto, Yutaka Nishiwaki
Journal: Journal of Thoracic Oncology (2010)
Ovine psittacosis and sarcoidosis in a pregnant woman.
Authors: B A Crosse, P Gomes, M M Muers
Journal: Thorax (1991)

A woman in the first trimester of pregnancy presented with pneumonia and hilar lymphadenopathy after exposure to lambing ewes. She subsequently aborted. Infection with Chlamydia psittaci of ovine origin was confirmed. Pregnant women are susceptible to this infection, which may cause life threatening disease. The patient also had features of sarcoidosis, and the two conditions ran a similar time course. There is a possibility that ovine psittacosis caused an illness indistinguishable from sarcoidosis.
Tolerance to aztreonam in patients allergic to betalactam antibiotics
Authors: J. M. Vega, M. Blanca, J. J. García, A. Miranda, M. J. Carmona, A. García, M. C. Moya, F. Sanchez, S. Terrados
Journal: Allergy (1991)

To evaluate the safe use of aztreonam (AZT) in patients allergic to penicillins and other betalactam antibiotics we studied 29 patients from a group of subjects allergic to betalactams, diagnosed by presenting systemic reactions after skin tests or challenge tests. Skin tests with benzylpenicilloyl (BPO), benzylpenicilloate, benzylpenicillin, ampicillin, amoxicillin, cephamandole and AZT, radioallergosorbent test (RAST) to BPO and AZT, RAST inhibition and challenge tests were performed. One patient was skin test‐positive to AZT, another patient was RAST AZT‐positive. IgE antibodies were specific to AZT as demonstrated by RAST inhibition studies with AZT coupled to epsilon‐amino caproic acid. Nevertheless, AZT was unable to inhibit either a pool of sera or individual sera positive to BPO. Although all our 29 patients tolerated the administration of AZT (including those with skin test or RAST positive) and AZT appears to be safe in these subjects, this does not indicate that all betalactam‐allergic patients tolerate AZT administration
Transsexualism and Transvestism
Authors: J. C. Barker
Journal: JAMA (1966)

<h3>To the Editor:—</h3> In your questions and answers column (<b>197</b>:599,1966) your correspondent Donald W. Hastings, MD, writes, "Transsexualism can be considered as a more complete role reversal than transvestism," implying that transsexualism and transvestism are part of one and the same continuum, with transsexualism as the more severe form. In my experience, transsexualism and transvestism are completely separate clinical and possibly pyschopathological entities. I explained this distinction (<i>Brit J Psychiat</i><b>11</b>:268, 1965): "In transsexualism the male patient both desires to be a woman and believes that he is one. To this end he may masquerade more or less continuously as a female." In transsexualism, unlike transvestism, "the process of dressing in female costume does not in itself provoke sexual excitation, but merely facilitates feminine disguise." It would seem that transvestism and fetishism (in which there is pathological sexual attachment to an object or objects other than the normal