Acute Hyperphosphatemia and Acute Persistent Renal Insufficiency Induced by Oral Phosphate Therapy
Authors: Gerardo Ayala, Bruce S. Chertow, Jayendra H. Shah, Gerald A. Williams, Subhash C. Kukreja
Journal: Annals of Internal Medicine (1975)

Letters1 October 1975Acute Hyperphosphatemia and Acute Persistent Renal Insufficiency Induced by Oral Phosphate TherapyGERARDO AYALA, M.D., BRUCE S. CHERTOW, M.D., F.A.C.P., JAYENDRA H. SHAH, M.D., GERALD A. WILLIAMS, M.D., F.A.C.P., SUBHASH C. KUKREJA, M.D.GERARDO AYALA, M.D.Search for more papers by this author, BRUCE S. CHERTOW, M.D., F.A.C.P.Search for more papers by this author, JAYENDRA H. SHAH, M.D.Search for more papers by this author, GERALD A. WILLIAMS, M.D., F.A.C.P.Search for more papers by this author, SUBHASH C. KUKREJA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-4-520 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIntravenous phosphate therapy alone or combined with oral phosphate therapy on occasion has caused metastatic calcification and renal impairment (1). This report documents a case in which oral phosphate therapy alone was associated with acute hyperphosphatemia and acute onset of persistent renal insufficiency.A 64-year-old black man with primary hyperparathyroidism was hospitalized for a neck exploration. Because of symptoms and signs of congestive heart failure and an electrocardiogram that showed changes consistent with a recent myocardial infarction, surgery was postponed.Admission laboratory data included the following: hematocrit, 36.2%; leukocyte count, 5200/mm3; blood urea nitrogen, 16 mg/100 ml (normal, 10 to...References1. CAREYSCHMITTKOPALD RGH: Massive extraskeletal calcification during phosphate treatment of hypercalcemia. Arch Intern Med 122:150-155, 1968 CrossrefMedlineGoogle Scholar2. ALBRIGHTBAUERCLAFLIN FWD: Studies in parathyroid physiology. III. The effect of phosphate ingestion in clinical hyperparathyroidism. J Clin Invest 11:411-435, 1932 CrossrefMedlineGoogle Scholar3. PURNELLSCHOLZSMITH DDL: Treatment of primary hyperparathyroidism. Am J Med 56:800-809, 1974 CrossrefMedlineGoogle Scholar4. GOLDSMITHINGBAR RS: Inorganic phosphate treatment of hypercalcemia of diverse etiologies. N Engl J Med 274:1-7, 1966 CrossrefMedlineGoogle Scholar5. GOLDSMITH R: Treatment of hypercalcemia. Med Clin North Am 56:951-960, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration West Side Hospital P.O. Box 8195 Chicago, Illinois 60680 University of Illinois College of Medicine 1853 West Polk Street Chicago, Illinois 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPhosphate nephropathy: an avoidable complication of bowel preparation for colonoscopyDrug-Induced Kidney Stones and Crystalline Nephropathy: Pathophysiology, Prevention and TreatmentEditorial: Risk vs. Reward: Is It Time to Purge Sodium Phosphate From Your Prep Portfolio?Safety of Oral Sulfates in Rats and Dogs Contrasted With Phosphate-Induced Nephropathy in RatsAcute Phosphate Nephropathy in a Kidney Transplant Recipient With Delayed Graft FunctionAdverse Renal and Metabolic Effects Associated with Oral Sodium Phosphate Bowel PreparationNephrology PotpourriOral sodium phosphate bowel purgatives and acute phosphate nephropathyDisorders of Calcium MetabolismColonoscopy Preparation: Are Our Patients at Risk?Oral Sodium Phosphate SolutionAcute Phosphate Nephropathy and Renal FailurePharmacological Treatment of Bone DisordersDisorders of Calcium MetabolismPrimary HyperparathyroidismSevere hyperphosphatemia following acute tumor lysis syndromePathophysiology and Management of Severe HypercalcemiaPrimary Hyperparathyroidism: A Surgical PerspectiveEfficacy of aminohydroxypropylidene diphosphonate in the treatment of malignancy‐associated hypercalcaemiaRelation between renal calcium content and renal impairment in 246 human renal biopsiesOncologic Emergencies I: Metabolic and Space-Occupying Consequences of Cancer and Cancer TreatmentAcute renal failure caused by extreme hyperphosphatemia after chemotherapy of an acute lymphoblastic leukemiasNephrotoxicity Caused by Cancer ChemotherapyInsuffisance rénale aiguë anurique par hyperphosphorémie au cours des leucémies aiguës lymphoblastiquesComparative study of available medical therapy for hypercalcemia of malignancyThe hypercalcemia of malignancy: Pathogenesis and managementNo Effect of Low-dose 1α-Hydroxycholecalciferol Treatment on the Renal Function Deterioration Rate in Long-term Uraemic RabbitsPrimary hyperparathyroidism: Hyperparathyroid crisisAcute tumor lysis syndromeVITAMIN-D ANALOGUES AND RENAL FUNCTIONSELF-TREATMENT OF COLD SORES WITH ICEOxygen availability from the blood and the effect of phosphate replacement on erythrocyte 2,3-diphosphoglycerate and haemoglobin-oxygen affinity in diabetic ketoacidosis 1 October 1975Volume 83, Issue 4Page: 520-521KeywordsBlood urea nitrogenCardiac surgeryElectrocardiographyHeart failureHematocritHyperparathyroidismMyocardial infarctionPhosphatesResearch laboratoriesSigns and symptoms Issue Published: 1 October 1975 PDF DownloadLoading ...