Jaundice from Troleandomycin and Oral Contraceptives
Authors: J.-P. MIGUET
Journal: Annals of Internal Medicine (1980)

Letters1 March 1980Jaundice from Troleandomycin and Oral ContraceptivesJ.-P. MIGUET, M.D., D. VUITTON, M.D., D. PESSAYRE, M.D., H. ALLEMAND, M.D., J.-M. METREAU, M.D., R. POUPON, M.D., J.-P. CAPRON, M.D., F. BLANC, M.D.J.-P. MIGUET, M.D.Search for more papers by this author, D. VUITTON, M.D.Search for more papers by this author, D. PESSAYRE, M.D.Search for more papers by this author, H. ALLEMAND, M.D.Search for more papers by this author, J.-M. METREAU, M.D.Search for more papers by this author, R. POUPON, M.D.Search for more papers by this author, J.-P. CAPRON, M.D.Search for more papers by this author, F. BLANC, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-3-434_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Separate administration of troleandomycin or oral contraceptives may cause jaundice (1, 2). In this letter, we suggest that the simultaneous administration of these agents markedly increases the risk of jaundice. In early 1978, we had the impression of a jaundice outbreak in patients taking both troleandomycin and oral contraceptives. This motivated us to survey in five French hospitals all the cases of jaundice that were occurring during the administration of troleandomycin, oral contraceptives, or both together.We found jaundice in 24 women receiving both troleandomycin and oral contraceptives; jaundice was observed, however, in only one woman taking...References1. TICKTINZIMMERMAN HJ. Hepatic dysfunction and jaundice in patients receiving triacetyloleandomycin. N Engl J Med. 1962;267:964-8. CrossrefGoogle Scholar2. KLATSKIN G. Toxic and drug-induced hepatitis. In: SCHIFF L, ed. Diseases of the Liver. 4th ed. Philadelphia: J. B. Lippincott, 1975:604-10. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J.-P. MIGUET, M.D.; D. VUITTON, M.D.; D. PESSAYRE, M.D.; H. ALLEMAND, M.D.; J.-M. METREAU, M.D.; R. POUPON, M.D.; J.-P. CAPRON, M.D.; F. BLANC, M.D.Affiliations: Hôpital Saint-Jacques 25030 Besancon France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHormonal contraceptives—oralMacrolide antibioticsTroleandomycinANTIBACTERIAL DRUGSSEX HORMONES AND RELATED DRUGSMacrolide antibioticsTroleandomycinHormonal contraceptives—oralGenetic predisposition to drug-induced hepatotoxicityEffects of troleandomycin and josamycin on thyroid hormone and steroid serum levels, liver function tests and microsomal monooxygenases in healthy volunteers: a double blind placebo-controlled studyTroleandomycin in the Treatment of Severe Asthma8 Acute and chronic drug-induced hepatitisOral contraceptive agents: current statusHuman drug metabolism in vitroJosamycin and troleandomycin increase hepatic glutathione turnover in ratsDrug Interactions with Oral ContraceptivesFormation of inactive cytochrome P-450 Fe(II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in ratsEffects of erythromycin on hepatic drug-metabolizing enzymes in humansDrugs and Liver Disease: A Tabular Compilation of Drugs and the Histopathological Changes That Can Occur in the LiverFormation of an inactive cytochrome P-450 Fe(II)-metabolite complex after administration of troleandomycin in humansCytochrome P-450 metabolic-intermediate complex formation and induction by macrolide antibiotics; a new class of agentsSelf-induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450Hypo activity of cytochrome P-450 after triacetyloleandomycin administrationOther antibiotic drugs 1 March 1980Volume 92, Issue 3Page: 434-434KeywordsOral contraceptive therapy ePublished: 1 December 2008 Issue Published: 1 March 1980 PDF downloadLoading ...