tbuckley/cabot-search huggingface dataset:
Abstract 3334: The role of nuclear HER3 in breast cancer resistance
Authors: Patrick Ming Kuen Tang, Ui Soon Khoo, Adrian L. Harris, Anthony Kong
Journal: Cancer Research (2014)

Abstract HER3 is reported to be overexpressed in 18-29% of human breast cancers and suggested to be a marker of reduced disease-specific survival in 4,406 patients with invasive breast carcinoma. Overexpression and subcellular localization of HER3 may be a negative predictive marker for targeted therapies, and HER3 status may play a role in the development of drug resistance and metastasis. Translocation of ERBB family members EGFR, HER2 and HER4 into nucleus for regulating gene transcription have been reported, but only a few studies about nuclear HER3 have been reported and the biological role of nuclear HER3 is still unknown. HER3 was detected in the nucleus of 57% in Japanese lung cancers, and has also been detected in the nuclei of prostate cancers and other cancer cell lines. A study suggested that nuclear HER3 by IHC is associated with favorable overall survival in 128 uveal melanoma patients. The potential mechanism of HER3 translocation and its role on drug resistance was intensively studied in the work. According to our observation, nuclear HER3 was found to be significantly increased in HER2-positive breast cancer cells SKBr3 during an EGFR-targeted therapy Iressa, and increased sub-band of HER3 was detected by Western blot in the Iressa-resistant SKBr3 cells. The Iressa-induced HER3 nuclear localization in SKBr3 and BT474 cells can be inhibited by the application of ADAM17 and gamma-secretase inhibitors or siRNA, the additional inhibitors can sensitize the cells to Iressa treatment which may be a new target for preventing HER3-mediated drug resistance. If the HER3 subcellular localization is important for cancer development and drug resistance, inhibitor for this pathway will enhance the efficiency of recent therapies on breast cancer. Citation Format: Patrick Ming Kuen Tang, Ui Soon Khoo, Adrian L. Harris, Anthony Kong. The role of nuclear HER3 in breast cancer resistance. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3334. doi:10.1158/1538-7445.AM2014-3334
TCT-585 Randomized Comparison Of Acute Stent Malapposition Between Platinum-chromium Versus Cobalt-chromium Everolimus-eluting Stents
Authors: Byeong-Keuk Kim, In Sook Kang, Dong-Ho Shin, Young-Guk Ko, Donghoon Choi, Jung-Sun Kim, Jung-Hee Lee, Yangsoo Jang, Myeong-Ki Hong
Journal: Journal of the American College of Cardiology (2014)
GUNSHOT WOUNDS OF THE KIDNEY. REPORT OF TWO CASES.
Authors: CHAS. H. LEMON
Journal: JAMA (1897)

Gunshot wounds of the kidney, the history of more than thirty years demonstrates, are among the rarer lesions that come under the surgeon's care. These organs by reason of their deep location escape the accidents that so frequently happen to the other abdominal viscera. Their importance to the human economy, their anatomic peculiarities and relation to the other viscera, the difficulty of making an exact diagnosis at the time of injury before an operation is undertaken or thought advisable, give to the history of individual cases a distinct interest, and will in time make the duty and responsibility of the surgeon clear, as additional light is shed upon this class of lesions in the operating room as well as at the postmortem table. Long before the era of antisepsis the necessity of providing free drainage in wounds of the kidneys was emphasized by Larrey and Dupuytren. The wisdom of this
The Wolff-Parkinson-White (WPW) Syndrome with Supernormal Conduction Through the Anomalous Bypass
Authors: PAUL L. MCHENRY, SUZANNE B. KNOEBEL, CHARLES FISCH
Journal: Circulation (1966)

An unusual case of WPW syndrome demonstrating a supernormal phase of conduction of the anomalous bypass is reported. It is suggested that the supernormality in the bypass tissue was due to concealed retrograde conduction into the bypass of the preceding normal ventricular wave of excitation.
H2O2 and 4-hydroxy-2,3-alkenals affect basal- and PDGF-dependent proliferation in human hepatic stellate cells (HSC)
Authors: G. Robino, A. Caligiuri, R. De Franco, C. Sali, M.U. Dianzani, P. Gentilini, M. Parola, M. Pinzani
Journal: Journal of Hepatology (1998)
Effect of Laser on Carcinoma in Man
Authors: Hubert L. Rosomoff
Journal: JAMA (1965)

THIS report, preliminary in nature, concerns itself with the effect of laser on the exposed surface of in vivo carcinoma in man. LASER is an acronym for Light Amplification by the Stimulated Emission of Radiation. It represents a technological advance in instrumentation by which atoms are stimulated to emit light in same phase and direction at a given frequency. This yields a unidirectional, coherent, intense, monochromatic beam of high energy content. When a solid-state system is used, a pulsed, high-peak power output is achieved which can be focused through a lens to an impact site, to produce a maximum in power density. Thus, the ruby laser used in this study was emitting light at a wave length of 6,943 Angstroms with the delivery of 1 to 3 joules of energy in a pulse duration of 0.0005 seconds. By calculation, this is a rated power output of 2,000 to 6,000 w.
807 TRIPLE THERAPY IN CHRONIC HEPATITIS C GENOTYPE 1. LIMITATIONS IN CLINICAL PRACTICE. SPANISH MULTICENTER STUDY
Authors: J. Crespo, B. Sacristan, J. Olcoz, R. Perez, J. Gonzalez, F. Garcia Pajares, J. de la Vega, R. Garcia, F. Saez Royuela, I. Garcia, F. Jimenez, M. Lopez Arias, C. Bailador, A. Cuadrado, A. Milla, O. Urquiza, E. Garcia Riesco, J. Cabezas, S. Menendez
Journal: Journal of Hepatology (2013)
Scottish general practitioners' attitudes and knowledge in respect of prescribing costs.
Authors: M Ryan, B Yule, C Bond, R J Taylor
Journal: BMJ (1990)

The government's proposal to introduce drug budgets will compel general practitioners to consider the financial consequences of prescribing. A survey was carried out of general practitioner principals in Grampian and a sample elsewhere in Scotland to examine their attitudes towards considering costs when prescribing and assess the accuracy of their knowledge of drug costs. Most general practitioners agreed that costs should be borne in mind when choosing medicines but their knowledge of drug costs was often inaccurate. Only one third of estimates were correct to within 25% of the actual cost, and there was a tendency to overstate the cost of cheap drugs and understate the cost of expensive ones. Some general practitioners were not aware of the relative prices of competing products or proprietary products and generic equivalents. The findings highlight the importance of providing general practitioners with readily accessible and up to date information on drug costs if prescribing budgets are to work.
Bioethics researchers support use of cognitive enhancers
Authors: K. Chinthapalli
Journal: BMJ (2013)

Leading bioethics researchers at a discussion forum have voiced their support for society to accept the use of drugs that enhance cognition.

Bennett Foddy, deputy director of the Institute for Science and Ethics at the University of Oxford, said, “There are stories throughout the last century where there has been a huge impact on human flourishing and wellbeing that has come about as a result of mass adoption of certain kinds of pills. I don’t think it’s crazy to think about these drugs as being a cheap option to get a positive effect. It’s hard for me to see what the objection is as long as it’s not, for example, replacing education.”

Cognition enhancing drugs include modafinil, methylphenidate, and some anticholinesterases. They are currently licensed only for the …
Sequelae of the adult respiratory distress syndrome.
Authors: R Hert, R K Albert
Journal: Thorax (1994)

Most survivors of ARDS have persistent mild reductions of TLCO even as long as a year after their episode. The lung volumes and flows return to normal in most instances, although a subset of patients will have persistent impairment. Both obstructive and restrictive deficits may be seen. This group may be predicted by the degree of acute lung injury assessed by the level of FIO2, PEEP, and gas exchange abnormality that exists in the first few days. In the first year after ARDS most physiological abnormalities will improve, but if deficits persist at one year further improvement is unlikely. Although many patients report dyspnoea following ARDS, the symptom does not correlate with abnormalities of pulmonary function. The possibility that conventional management may augment the degree of acute injury and worsen outcome must be considered. The effects of chronic hyperoxia in humans with acute lung injury or those of high levels of PEEP compared with low levels are not known. Exploring new ventilator management strategies while we await more specific treatment directed at the primary problem of acute lung inflammation will hopefully reduce acute mortality as well as acute and chronic morbidity.
Say You/Say Me: Notice of Plagiarism-Reply
Authors: John Hardy
Journal: JAMA (1988)

<h3>In Reply.—</h3> I have been happy to acknowledge that I based the form of my poem "Say 1944/For My Father" on Stanley Plumly's poem "Say Summer/ For My Mother"1 when I composed it as an undergraduate student in 1980.I did my best to preserve this form while providing the unique images and emotive force that described my relationship with my father. I regret the difficulties that have arisen as they relate to the origin of my poem's form.
Toxoplasma infection in an urban community
Authors: J. H. Price
Journal: BMJ (1969)

A survey was undertaken in an urban community to examine the intrafamilial epidemiology of toxoplasma infection and its relation to a set of environmental variables. Statistically significant relations were found with (a) ownership of a dog or cat; (b) the handling of pet food, particularly cat food; and (c) a "risk" score compounded from the handling of pet food and lack of cleanliness in the kitchen.
Overmanagement of the Alcoholic Patient
Authors: M. J. Finer
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Experience with 1,000 alcoholics during the past four years has impressed the staff of this alcoholism treatment program with the fact that excessive and costly medications are frequently thrust upon the alcoholic needlessly. This "treatment" consists of a barrage of medications derived mainly from tradition rather than genuine need. Physicians, nurses, relatives, and patients are reluctant to forego this traditional "therapy" because the "giving" and "getting" of a tangible "something" substitutes for more complex and difficult treatment of the primary problem. Early in this program, we (staff and patients) also obtained a comfortable feeling of achievement from the daily and then three times weekly injections of cyanocobalamin for six weeks, orally given multivitamins for months, tranquilizer for variable indefinite periods, "sleepers," etc. Alcoholics are quite willing to continue such therapy after the actual need has vanished. Many physicians are willing to do the honors. If one postulates
Low p27 Expression Predicts Early Relapse and Death in Postmenopausal Hormone Receptor–Positive Breast Cancer Patients Receiving Adjuvant Tamoxifen Therapy
Authors: Martin Filipits, Margaretha Rudas, Harald Heinzl, Raimund Jakesz, Ernst Kubista, Sigurd Lax, Walter Schippinger, Otto Dietze, Richard Greil, Wolfgang Stiglbauer, Werner Kwasny, Alexander Nader, Michael Stierer, Michael F.X. Gnant
Journal: Clinical Cancer Research (2009)

Previously, we have shown that p27 may be a potential predictive biomarker for the selection of premenopausal women with early-stage hormone-responsive breast cancer for adjuvant endocrine therapy. The purpose of the present study was to assess the clinical relevance of p27 expression in postmenopausal hormone receptor-positive breast cancer patients who were treated with adjuvant tamoxifen therapy.We determined the expression of p27 by immunohistochemistry in the surgical specimens of breast carcinoma patients who had been enrolled in Austrian Breast and Colorectal Cancer Study Group Trial 06 and received tamoxifen for 5 years. Early relapse and death within the first 5 years of follow-up were analyzed using Cox models adjusted for clinical and pathologic factors.p27 expression was high (>70% p27-positive tumor cells) in 252 of 483 (52%) tumor specimens and was associated with favorable outcome of the patients. Women with high p27 expression had a significantly longer disease-free survival (adjusted hazard ratio for relapse, 0.22; 95% confidence interval, 0.11-0.42; P < 0.001) and overall survival (adjusted hazard ratio for death, 0.39; 95% confidence interval, 0.21-0.72; P = 0.002) as compared with women with low p27 expression.Low p27 expression independently predicts early relapse and death in postmenopausal women with early-stage, hormone receptor-positive breast cancer who received adjuvant tamoxifen for 5 years.
Elevated Expression of ISG15 in Tumor Cells Interferes with the Ubiquitin/26S Proteasome Pathway
Authors: Shyamal D. Desai, Arthur L. Haas, Laurence M. Wood, Yu-Chen Tsai, Sidney Pestka, Eric H. Rubin, Ahamed Saleem, Alam Nur-E-Kamal, Leroy F. Liu
Journal: Cancer Research (2006)

IFN-stimulatory gene factor 15 (ISG15) is a ubiquitin-like protein, which is conjugated to many cellular proteins. However, its role in protein degradation is unclear. Here, we show that ISG15 is highly elevated and extensively conjugated to cellular proteins in many tumors and tumor cell lines. The increased levels of ISG15 in tumor cells were found to be associated with decreased levels of polyubiquitinated proteins. Specific knockdown of ISG15 expression using ISG15-specific small interfering RNA (siRNA) was shown to increase the levels of polyubiquitinated proteins, suggesting an antagonistic role of ISG15 in regulating ubiquitin-mediated protein turnover. Moreover, siRNA-mediated down-regulation of the major E2 for ISG15 (UbcH8), which blocked the formation of ISG15 protein conjugates, also increased the levels of polyubiquitinated proteins. Together, our results suggest that the ISG15 pathway, which is deregulated during tumorigenesis, negatively regulates the ubiquitin/proteasome pathway by interfering with protein polyubiquitination/degradation.
Long-Term Results of Radiofrequency Ablation Treatment of Stage I Non-small Cell Lung Cancer: A Prospective Intention-to-Treat Study
Authors: Marcello Carlo Ambrogi, Olivia Fanucchi, Roberto Cioni, Paolo Dini, Annalisa De Liperi, Carla Cappelli, Federico Davini, Carlo Bartolozzi, Alfredo Mussi
Journal: Journal of Thoracic Oncology (2011)
Hepatic Necrosis After Enflurane Anesthesia
Authors: Leo van der Reis
Journal: JAMA (1974)

To the Editor.—  Methoxyflurane, halothane, and their metabolites have been reported to cause adverse reactions, primarily in the form of liver injury. 1,2 Cross-sensitivity between these agents has also been reported. 3 Even though serious adverse reactions are rare, fatalities ascribed to these agents seem to have occurred.    Enflurane (Ethrane), a newer anesthetic agent, has become widely used with considerable safety. It is not entirely unexpected, though, that liver injury would sooner or later follow.  In the following case, an adverse reaction to enflurane may have occurred.  Report of a Case.—  A 62-year-old diabetic woman with a complaint of right upper abdominal pain underwent cholecystectomy for cholecystitis with cholelithiasis. A liver biopsy specimen obtained at surgery showed unsuspected cirrhosis. The patient, who had no previous exposure to halothane or enflurane, received enflurane, sodium pentothal, curare, and succinylcholine. There was no history of previous viral hepatitis or hepatitis contact. On admission,
Drinking and driving: success of random breath testing in Finland.
Authors: J A Dunbar, A Penttila, J Pikkarainen
Journal: BMJ (1987)

Since the introduction of random breath testing in Finland in 1977 the drinking and driving rate has halved, and there has been an appreciable reduction in the rates of death and injury from road accidents associated with drinking. The results of Finnish studies indicate that random breath testing deters social drinkers and detects problem drinkers. Problem drinkers are more likely to be driving in morning traffic, when vulnerable road users such as children are about, and are more likely to be detected by random breath testing than by any other police activity. Random breath testing is a popular measure and has not only saved lives but has paid for itself by savings in health service and other resources. Introducing random breath testing into Britain could save at least 400 lives a year. The main recommendation of the Blennerhassett report of 1976--discretionary testing--is compared with the success of random breath testing in Finland.
Totally Cloth-Covered Prostheses
Authors: ROBERT HODAM, ALBERT STARR, DON RAIBLE, HERBERT GRISWOLD
Journal: Circulation (1970)

This report deals with our experience with totally cloth-covered prostheses over a 28-month period from April, 1967 to August, 1969. During this interval 223 patients were treated with an operative mortality of 11%. The earliest model cloth-covered prosthesis proved in some instances to have an excessively large transprosthetic gradient. 8,9 The introduction of the composite seat design, however, has resulted in a prosthesis with very favorable hydraulic characteristics, as shown by late postoperative catheterization studies. Early follow-up data indicate that the composite seat style prostheses have a favorably low rate of thromboembolic complications. In 88 patients receiving this style valve, there have been no early emboli and only one late embolus, despite the fact that a portion of the group are not taking anticoagulants. We stress, however, that these still represent short-term observations and must stand the test of time. Until the results of the double-blind study are completed, we continue to recommend long-term anticoagulation for all patients in whom this can be safely done. The composite seat style totally cloth-covered prosthesis is recommended for all patients who are reoperated for ball variance. We also feel it should be considered strongly for young persons undergoing aortic valve replacement and for patients who for medical or social reasons cannot be safely anticoagulated.
Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia
Authors: Russell E. Ware, Jenny M. Despotovic, Nicole A. Mortier, Jonathan M. Flanagan, Jin He, Matthew P. Smeltzer, Amy C. Kimble, Banu Aygun, Song Wu, Thad Howard, Alex Sparreboom
Journal: Blood (2011)
PROPHYLAXIS IN ALCOHOLICS IN THE WITHDRAWAL PERIOD
Authors: P. J. F. WALSH
Journal: American Journal of Psychiatry (1962)

Attention is drawn to the occasional appearance of Korsakov's psychosis immediately after a convulsive seizure in chronic alcoholics and to the possibility that withdrawal fits may contribute to the dementia seen in some chronic alcoholics. The routine prophylactic use of anticonvulsants and B vitamins in the withdrawal period is advocated and described.
Needling doubts about where to vaccinate
Authors: N R Grist, D Reid, E Walker
Journal: BMJ (1988)

provement has occurred in the Hospital Activity Analysis compared with previous reports, it re- mains an inadequate source of data for both clinicians and management.Critical clinical infor- mation is lacking without which assessment of, for example, length of stay becomes meaningless.A national inspectorate using this health service information will fail miserably for both the quality and quantity of this data fall a long way below the standards expected in the late 1980s.
BM-18 * PROLONGED RESPONSE WITH BEVACIZUMAB + NAVELBINE AS THIRD LINE OF TREATMENT OF BREAST CANCER LEPTOMENINGEAL METASTASES: A CASE REPORT
Authors: E. Le Rhun, S. Taillibert, F. Zairi, T. Boulanger, I. Farre, N. Deligny, T. Bachelot, J. Bonneterre
Journal: Neuro-Oncology (2014)

Approximately 5% of breast cancer (BC) will develop leptomeningeal metastases (LM) during the course of the disease. The median overall survival remains limited to several months despite aggressive treatment. We report the case of a patient with a prolonged response to bevacizumab (BEV) and vinorelbine as third line of treatment of LM. A 29-year-old patient was diagnosed in 2008 with an invasive ductal carcinoma with negative hormonal receptors and overexpressed HER2. She initially received neoadjuvant chemotherapy plus trastuzumab, surgery and radiotherapy. She presented in December 2011 with hepatic, bones and lung metastases and received docetaxel plus trastuzumab during 6 months then trastuzumab alone. Nodular LM were diagnosed in September 2012 and the patient was enrolled in a trial and received intra-CSF and intra-venous (iv.) trastuzumab plus capecitabine. A first isolated progression of LM was diagnosed in February 2013, and was treated with a combination of intraventricular liposomal cytarabine, lapatinib, iv. trastuzumab and capecitabine. A second isolated LM progression was observed in May 2013. At that time, the patient presented with a cauda equina syndrom and cerebellar impairment leading to the need of a wheeling chair and assistance in her daily life. She received sites-specific radiotherapy (cauda equina + posterior fossa) and a BEV + vinorelbine association was initiated. Treatment was well tolerated. A rapid functional improvement occurred and the patient was able to walk again and to handle her daily activities. In April 2014, she presented with rapidly progressive headaches and vomiting. Only one cycle of trastuzumab and paclitaxel could be given as the medical condition impaired very quickly. Due to the important improvement of the general condition of our patient with initially bulky LM of the posterior fossa and due to the prolonged response observed, BEV in combination with chemotherapy should be considered for these patients.
IKKα modulates primary sclerosing cholangitis and intrahepatic cholangiocarcinoma
Authors: Qun Jiang, Anthony J Scarzello, Zuoxiang Xiao, Timothy Back, Jami Willette-Brown, Feng Zhu, Yinling Hu, Robert H Wiltrout
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer after hepatocellular carcinoma (HCC). The risk of ICC is higher in patients with primary sclerosing cholangitis (PSC). To date, the cellular and molecular mechanism underlying the pathological
Total body irradiation, etoposide, cyclophosphamide, and autologous peripheral blood stem-cell transplantation followed by randomization to therapy with interleukin-2 versus observation for patients with non-Hodgkin lymphoma: results of a phase 3 randomized trial by the Southwest Oncology Group (SWOG 9438)
Authors: John A. Thompson, Richard I. Fisher, Michael LeBlanc, Stephen J. Forman, Oliver W. Press, Joseph M. Unger, Auayporn P. Nademanee, Patrick J. Stiff, Stephen H. Petersdorf, Alexander Fefer
Journal: Blood (2008)
Langer's Axillary Arch
Authors: Gaspare F. Saitta
Journal: JAMA (1962)

THE DIFFERENTIAL diagnosis of an axillary mass as Langers Arch is sufficiently uncommon to warrant recording such a case. Report of a Case A 10-year-old boy was admitted to the hospital for diagnosis and treatment of a right axillary mass which was first noted by his mother several weeks before. The mass was asymptomatic: both mother and son were certain that it had not been present previously. Examination revealed a definite fullness of the right axilla which was not present on the left. This mass, quite firm in consistency, was most prominent when the arm was abducted to 90 degrees: it seemed to disappear when the arm was brought down to the side. Physical examination was otherwise negative. Chest x-ray, blood, and urine studies were noncontributory. Because of the obscure nature of the mass and the anxiety of the parents, exploration of the riuht axilla was done. The exploration was