tbuckley/cabot-search huggingface dataset:
Headache and Hypertension
Authors: Marvin Moser
Journal: JAMA (1962)

A 3-year study of 54 patients with headache and hypertension was undertaken in an attempt to establish criteria for the diagnosis of the so-called "hypertensive headache." Frontal or occipital early morning headaches occurred most frequently, but the type of headache could not be clearly defined. Headaches frequently antedated the onset of hypertension. Over 50 per cent of patients experienced either relief from headache or significant fall in blood pressure after antihypertensive drug therapy. Less than 30 per cent, however, noted relief of headache and a satisfactory blood pressure response. Of 1,296 patients analyzed, only 20.5 per cent of those with hypertension had migraine headaches. Only 35.4 per cent of those with migraine had hypertension.
VOLVULUS OF THE SMALL INTESTINE
Authors: J. W. G. Grant
Journal: BMJ (1925)

TmIs case appeared to mie to be so unuiistual as to be worth i'ecorIding.In twenty years I had niot seen sutchi anolther nior lhave I fouind ally rofelferleco to the conditioni in the literature I possess.In October, 1923, I was called to see a gentleman of 70 who, wlhile gardening, three days previously, had been bitteni by an insect on the back of the neck, just within the hair nmargin.At iirst.it.chy,the bite and its imnmediate surroundings became within at few holurs hot, painflul, anld swollen.When I saw hirn there wAas a patch on the niucha the size of a florin, tense, red, and with its 9surface studded over with papules and with pustules, each
A new indoor allergen from a common non‐flowering plant
Authors: I. G. K. Axelsson, S. G. O. Johansson, O. Zetterströ
Journal: Allergy (1987)

Ficus benjamina or weeping fig (w‐fig) is one of the most common indoor non‐flowering green plants in northern Europe. We have previously reported that occupational exposure to w‐fig in plant keepers, both atopic and non‐atopic, gives rise to IgE‐mediated allergy with airway symptoms. About one‐fourth of the plant keepers had become sensitized. We now report a study of sensitization in non‐occupationally exposed persons comprising 395 patients, consecutively referred for allergological investigation, and 107 employees from two offices decorated with an abundance of w‐figs. Of the patients, 56% were found to be atopic and more than half of them reported exposure to w‐fig. Sensitization, as judged by a positive skin prick test and positive RAST, was found in 13 of the patients and in three of the employees. All of them suffered from rhinitis and/or asthma and were atopics and sensitized to one or several common allergens. We conclude that sensitization to w‐fig is not uncommon and that in Sweden it is of the same magnitude as sensitization to the most common mould, Cladosporium herbarum. The risk that subjects with a genuine atopic constitution exposed to w‐fig will become sensitized is about 6 %. In approximately half of the patients the sensitization was considered to be clinically important.
Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma
Authors: Fernando Ussa, Itziar Fernandez, Maria Brion, Angel Carracedo, Francisco Blazquez, Maria T. Garcia, Ana Sanchez-Jara, Lourdes De Juan-Marcos, Soledad Jimenez-Carmona, Jose R. Juberias, Jose M. Martinez-de-la-Casa, Jose C. Pastor
Journal: Ophthalmology (2015)
Colonisation with multidrug-resistant bacteria is associated with increased mortality in patients with cirrhosis
Authors: Oliver Waidmann, Volkhard A Kempf, Christian Brandt, Stefan Zeuzem, Albrecht Piiper, Bernd Kronenberger
Journal: Gut (2015)

We read with interest the recent paper by Angeli et al 1 investigating the acute-on-chronic liver failure classification in comparison to the acute kidney injury classification as a prognostic parameter in patients with decompensated cirrhosis. Higher stages of acute-on-chronic liver failure were accompanied with mortality and more frequently bacterial infections were identified in patients with multiorgan failure in this large cohort of patients. It is well known that patients with cirrhosis are at high risk for bacterial infections and bacterial infections are common causes of hepatic decompensations.2 Infectious complications significantly impair patients’ prognosis.2 ,3 However, especially hospital acquired infections are associated with high mortality.3 A common additional challenge is the worldwide …
Whose Death Is It, Anyway
Authors: Valery A. Portnoi
Journal: Annals of Internal Medicine (1997)

Letters1 April 1997Whose Death Is It, AnywayValery A. Portnoi, MDValery A. Portnoi, MDGenesis Physician Services, Inc., Washington, DC 20037Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-7-199704010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Gilligan and Raffin draw a picture of intensive hospital care at the end of life as nothing short of medical abuse, “akin to battery” [1]. A neurologist, cardiologist, and pulmonologist were called to patient's bedside. However, this is an established medical practice that allows ascertainment of a patient's potential for survival and the reversibility of nonterminal conditions. The authors see these attempts as a reflection of an anachronistic medical culture and cite SUPPORT (Study to Understand Prognosis and Preferences for Outcome and Risk of Treatments) [2] to buttress their view. Indeed, in the culture of death, dying ...References1. Gilligan T, Raffin T. Whose death is it, anyway? Ann Intern Med. 1996; 125:137-41. Google Scholar2. A controlled trial to improve care for seriously ill hospitalized patients. The Study to Understand Prognosis and Preferences for Outcome and Risks of Treatments (SUPPORT). The SUPPORT principal investigators. JAMA. 1995; 274:1591-8. Google Scholar3. Bergner L, Bergner M, Hallstrom AP, Eisenberg M, Cobb LA. Health status of survivors of out-of-hospital cardiac arrest six months later. Am J Public Health. 1984; 74:508-10. Google Scholar4. Lai SM, Alter M, Friday G, Sobel E. Prognosis for survival after initial stroke. Stroke. 1995; 26:2011-5. Google Scholar5. Cowley LT, Young E, Raffin JA. Care of the dying: an ethical and historical perspective. Crit Care Med. 1992; 20:1473-82. Google Scholar Author, Article, and Disclosure InformationAffiliations: Genesis Physician Services, Inc., Washington, DC 20037 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1997Volume 126, Issue 7Page: 587-588KeywordsCaregiversDisabilitiesElderlyEnd of life carePatientsStroke rehabilitation Issue Published: 1 April 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The Results of Irradiation Therapy of Carcinoma of the Cervix
Authors: E. L. Makowski
Journal: JAMA (1962)

The effectiveness of accurately applied irradiation therapy for carcinoma of the cervix was determined. In our study, 1,178 patients with carcinoma of the cervix were given primary irradiation therapy. Nine patients had primary surgical therapy and 15 patients had no therapy. External irradiation was administered first. On the last day of external irradiation treatment, radium was inserted into the upper vagina, cervix, and uterus. The patients in the various stages were grouped as follows: 422 patients had Stage 1 lesions, 426 patients had Stage 2 lesions, 286 patients had Stage 3 lesions, and 59 patients had Stage 4 lesions. The absolute 5-year-survival rates were 81% for Stage 1, 60% for Stage 2, 35% for Stage 3, and 3% for Stage 4. The over-all 5-year survival rate was 58.8%.
Confirmation of raised phospholipase A2 activity in the uninvolved skin of psoriasis
Authors: A. Verhagen, Mieke Bergers, P.E.J. Erp, J.M. Gommans, P.C.M. Kerkhof, P.D. Mier
Journal: British Journal of Dermatology (1984)

Phospholipase A2 has been measured in the lesions and the ‘uninvolved’ skin of patiens with psoriasis. We confirm a previous report that there is a generalized increase in the activity of this enzyme in psoriatic skin.
Germany plans to introduce electronic health card
Authors: Annette Tuffs
Journal: BMJ (2004)

The German government will start what it describes as the most extensive e-health communication project in the world next year, a spokesperson from the health ministry has announced.

From 1 January 2006 all 72 million customers of the health insurance companies in Germany, which give access to state health care, should be using a “health card” with a microchip when they see a doctor, attend a clinic, or buy a drug. It will replace the present membership …
Removal of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption
Authors: Stephan B Felix, Alexander Staudt, Martin Landsberger, Yvonne Grosse, Verena Stangl, Thomas Spielhagen, Gerd Wallukat, Klaus D Wernecke, Gert Baumann, Karl Stangl
Journal: Journal of the American College of Cardiology (2002)
The role of action representations in the dynamics of embodied cognition
Authors: Natika Newton
Journal: Behavioral and Brain Sciences (2001)

Thelen et al. present a convincing explanation of the A-not-B error, but contrary to their own claims, their explanation essentially involves mental representations. As is too common among cognitive scientists, they equate mental representations with representations of external physical objects. They clearly show, however, that representations of bodily actions on physical objects are central to the dynamical system producing the error.
Early Remodeling of Perinuclear Ca <sup>2+</sup> Stores and Nucleoplasmic Ca <sup>2+</sup> Signaling During the Development of Hypertrophy and Heart Failure
Authors: Senka Ljubojevic, Snjezana Radulovic, Gerd Leitinger, Simon Sedej, Michael Sacherer, Michael Holzer, Claudia Winkler, Elisabeth Pritz, Tobias Mittler, Albrecht Schmidt, Michael Sereinigg, Paulina Wakula, Spyros Zissimopoulos, Egbert Bisping, Heiner Post, Gunther Marsche, Julie Bossuyt, Donald M. Bers, Jens Kockskämper, Burkert Pieske
Journal: Circulation (2014)

A hallmark of heart failure is impaired cytoplasmic Ca(2+) handling of cardiomyocytes. It remains unknown whether specific alterations in nuclear Ca(2+) handling via altered excitation-transcription coupling contribute to the development and progression of heart failure.Using tissue and isolated cardiomyocytes from nonfailing and failing human hearts, as well as mouse and rabbit models of hypertrophy and heart failure, we provide compelling evidence for structural and functional changes of the nuclear envelope and nuclear Ca(2+) handling in cardiomyocytes as remodeling progresses. Increased nuclear size and less frequent intrusions of the nuclear envelope into the nuclear lumen indicated altered nuclear structure that could have functional consequences. In the (peri)nuclear compartment, there was also reduced expression of Ca(2+) pumps and ryanodine receptors, increased expression of inositol-1,4,5-trisphosphate receptors, and differential orientation among these Ca(2+) transporters. These changes were associated with altered nucleoplasmic Ca(2+) handling in cardiomyocytes from hypertrophied and failing hearts, reflected as increased diastolic Ca(2+) levels with diminished and prolonged nuclear Ca(2+) transients and slowed intranuclear Ca(2+) diffusion. Altered nucleoplasmic Ca(2+) levels were translated to higher activation of nuclear Ca(2+)/calmodulin-dependent protein kinase II and nuclear export of histone deacetylases. Importantly, the nuclear Ca(2+) alterations occurred early during hypertrophy and preceded the cytoplasmic Ca(2+) changes that are typical of heart failure.During cardiac remodeling, early changes of cardiomyocyte nuclei cause altered nuclear Ca(2+) signaling implicated in hypertrophic gene program activation. Normalization of nuclear Ca(2+) regulation may therefore be a novel therapeutic approach to prevent adverse cardiac remodeling.
Steroidogenic Germline Polymorphism Predictors of Prostate Cancer Progression in the Estradiol Pathway
Authors: Éric Lévesque, Isabelle Laverdière, Étienne Audet-Walsh, Patrick Caron, Mélanie Rouleau, Yves Fradet, Louis Lacombe, Chantal Guillemette
Journal: Clinical Cancer Research (2014)

Reliable biomarkers that predict prostate cancer outcomes are urgently needed to improve and personalize treatment approaches. With this goal in mind, we individually and collectively appraised common genetic polymorphisms related to estradiol metabolic pathways to find prostate cancer prognostic markers.The genetic profiles of 526 men with organ-confined prostate cancer were examined to find common genetic polymorphisms related to estradiol metabolic pathways and these findings were replicated in a cohort of 213 men with more advanced disease (follow-up time for both cohorts, >7.4 years). Specifically, we examined 71 single-nucleotide polymorphisms (SNP) in SULT2A1, SULT2B1, CYP1B1, COMT, CYP3A4, CYP3A5, CYP3A43, NQO1, and NQO2 and assessed the impact of the SNPs alone and in combination on prostate cancer progression and on circulating hormone levels.According to a multivariate analysis, CYP1B1 (rs1800440), COMT (rs16982844), and SULT2B1 (rs12460535, rs2665582, rs10426628) were significantly associated with prostate cancer progression and hormone levels. Remarkably, by combining the SNP information with previously identified HSD17B2 markers, the patients could be stratified into four distinct prognostic subgroups. The most prominent association was observed for the eight-marker combination [CYP1B1 (rs1800440), SULT2B1 (rs12460535, rs2665582, and rs10426628), and HSD17B2 (rs4243229, rs1364287, rs2955162, and rs1119933)].This study identified specific germline variations in estradiol metabolism-related pathways, namely CYP1B1, SULT2B1, and HSD17B2, as novel prognostic markers that are cumulatively associated with increased risk of prostate cancer progression. This panel of markers warrants additional investigation and validation to help stratify patients according to their risk of progression. Clin Cancer Res; 20(11); 2971-83. ©2014 AACR.
Medically irreversible status asthmaticus in children. Report of three cases treated with paralysis and controlled respiration
Authors: L. R. Beam
Journal: JAMA (1965)

Three children who were moribund because of severe status asthmaticus survived. They were treated by muscle paralysis, endotracheal intubation, and controlled respiration when vigorous medical therapy appeared to have failed. One patient had four such experiences. This method of treatment is indicated only for the purpose of gaining adequate time for medical therapy to become effective. The occurrence of adrenalin fastness in respiratory acidosis, the additive effect of antibiotics on curarization, and the use of sedation warrant caution. The advantages of this method over those of inhalation anesthesia are many.
Sphygmomanometer Armlet as Tourniquet
Authors: R. L. Wynne
Journal: BMJ (1947)

<h3>Abstract</h3> <h3>Background</h3> Low income and food insecure households are at risk of poor dietary quality and food insecurity. Especially in childhood, consuming a nutritionally adequate diet is an essential driver of health, growth, and development. Prior research has shown many household-level factors can present challenges to support the nutritional needs of the members of low income and food insecure households. <h3>Objective</h3> The aim of the scoping review is to identify the contributing factors to dietary quality and food security in U.S. households of school-aged children and synthesize the evidence. <h3>Methods</h3> The scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols Extension for Scoping Reviews (PRISMA-ScR) using search terms addressing food insecurity, low-income and dietary behaviors in the database PubMed (NCBI). Screening by 3 independent reviewers at the title, abstract, and full study phases identified forty-three studies included in the review. <h3>Results</h3> The studies addressed six themes: parental behaviors, child/adolescent behaviors, food procurement behaviors, food preparation behaviors, and psychosocial factors. Most studies were cross-sectional (n = 40, 93%) and focused on parental behaviors (n = 24, 56%), followed by food procurement behaviors, and food preparation behaviors. <h3>Conclusion</h3> The findings can be used to inform the development of future nutritional education interventions aimed at improving the dietary quality and food security in households with children. The themes identified were interrelated and suggest that providing parents with education on the following topics: 1) the importance of modeling positive eating behaviors in the home, 2) approaches to support and encourage positive feeding practices with their children, and 3) practical strategies to overcome barriers to purchasing and preparing foods of high nutrient quality. For example, delivering educational sessions on meal selection and preparation and improving nutritional knowledge hold promise to improve dietary quality among food insecure and low-income households.
Recently Discovered T Cell Subsets Cannot Keep Their Commitments
Authors: Terry B. Strom, Maria Koulmanda
Journal: Journal of the American Society of Nephrology (2009)

After activation by antigen/MHC (signal 1) and CD28-dependent co-stimulation (signal 2), resting CD4(+) T cells commit to one of a variety of functionally and molecularly defined phenotypes. Two long established CD4 phenotypes, Th1 and Th2 cells, have been regarded as terminally differentiated formats. Recently, two additional phenotypes, tissue-protective regulatory (Tregs) and tissue-destructive Th17 T cells, have also been discovered, and neither represents a terminally differentiated phenotype. Rather, Tregs and Th17(+) cells respond to cues provided by the inflammatory texture in which these cells reside. We review the important scientific and therapeutic implications of these differences herein.
An inhibitory effect of furosemide on sodium reabsorption by the proximal tubule of the rat nephron
Authors: Barry M. Brenner, Robert I. Keimowitz, Fred S. Wright, Robert W. Berliner
Journal: Journal of Clinical Investigation (1969)

The evidence from previous micropuncture studies for an inhibitory effect of furosemide on proximal sodium reabsorption in the rat has been conflicting. Intrinsic reabsorptive capacity, estimated in free flow and shrinking drop experiments, has been reported to be depressed, whereas fractional reabsorption usually remains unchanged. We have recently reported that, during conditions of elevated intraluminal hydrostatic pressure, unless care is taken to prevent retrograde flow of tubule fluid from more distal sites, the concentration of inulin in late proximal fluid is often factitiously elevated. Since furosemide raises intraluminal pressures, often markedly, the failure to detect a depression of fractional reabsorption might be the consequence of retrograde contamination during fluid collection. Experiments were designed to compare the effect of furosemide on fractional sodium reabsorption by the proximal tubule when collections were obtained with distal oil blocks of conventional length as well as with unusually long blocks of oil of low and high viscosities. When reflux is prevented, fractional sodium reabsorption is usually depressed by furosemide, whereas when conventional distal blocks are used, the calculated values for fractional reabsorption either remain unchanged or increase. Simultaneous measurements of nephron glomerular filtration rate indicate that the latter is the consequence of retrograde contamination.
Abstract 4861: Identification of novel potential targets for selenomethionine-mediated chemoprevention in colorectal carcinoma mouse model via proteomics analysis.
Authors: Md. Mujibur Rahman, Jee Young Kwon, Young Rok Seo
Journal: Cancer Research (2013)

Abstract Despite some controversy, selenomethionine (SeMet) mediated protection against colorectal carcinoma (CRC) might be a very promising non-cytotoxic option. However, responsive molecular targets and underlying mechanisms of SeMet mediated chemoprevention are still unclear. Our aim was to discover new targets of SeMet mediated chemoprevention in CRC using proteomics analysis. We found dietary SeMet supplementation before carcinoma initiation effectively suppressed polyp incidence and dysplastic lesions without any adverse effects. To determine chemopreventive targets of SeMet, we employed 2-dimensional gel electrophoresis based proteomics analysis in CRC mouse model. Pretreatment with SeMet apparently modulated the expression of 30 proteins with functions in major processes like chronic inflammation, oxidative-stress and apoptosis as discovered through pathway analysis with Pathway studio software.We validated four proteins selected from pathway analysis including prohibitin, purine nucleoside phosphorylase, annexin 2 and c-reactive protein by immuno-histochemistry. 8-hydroxy-2′-deoxyguanosine (8-OHdG), a known oxidative stress marker was decreased by SeMet treatment in CRC mice as seen by immunohistochemistry. Further network analysis was done among these new four validated proteins, 8-OHdG and colorectal cancer. These four proteins found by proteomics analysis might be considered as potential chemopreventive biomarkers of SeMet against colon cancer and can help develop and improve approaches in preventive, therapeutic and prognostic aspects. Citation Format: Md. Mujibur Rahman, Jee Young Kwon, Young Rok Seo. Identification of novel potential targets for selenomethionine-mediated chemoprevention in colorectal carcinoma mouse model via proteomics analysis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4861. doi:10.1158/1538-7445.AM2013-4861
The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells
Authors: Hai Wang, Cuijuan Yu, Xia Gao, Thomas Welte, Aaron M. Muscarella, Lin Tian, Hong Zhao, Zhen Zhao, Shiyu Du, Jianning Tao, Brendan Lee, Thomas F. Westbrook, Stephen T.C. Wong, Xin Jin, Jeffrey M. Rosen, C. Kent Osborne, Xiang H.-F. Zhang
Journal: Cancer Cell (2015)
Maternal serum and amniotic fluid concentrations of alphafetoprotein in epidermolysis bullosa simplex.
Authors: T Yacoub, C A Campbell, Y B Gordon, J D Kirby, M J Kitau
Journal: BMJ (1979)

proportionating system was dismantled and a gas leak found in the Cambridge Bourdon tube type dialysate temperature gauge which caused the needle pointer to register about 20'C too low.The fault had come on over a period of time and, unfortunately, it had been assumed that the Cambridge gauge was indicating the true dialysate temperature.Therefore the back-up temperature alarm system and the dialysate heater were adjusted to maintain the Cambridge gauge recording in the range 35-41°C.Probably, however, the dialysate was much hotter (possibly as much as 58°C).with topical corticosteroid treatment only and the baby was discharged home after 21 days.AFP concentrations in the bullous fluid and neonatal serum were 6-0 and 5-6 mg/l respectively, indicating transudation of serum.