tbuckley/cabot-search huggingface dataset:
A Case Report on California's Proposition 65-Reply
Authors: Thomas E. Warriner
Journal: JAMA (1989)

<h3>In Reply.—</h3> Dr Berger appears to have completely missed the point of our article on Proposition 65. His letter underscores several of the points we made about the legal and scientific difficulties of this new law, and while some of his points have merit, proposition 65 is now the law in California. Several similar measures are being pursued in other states. Granted, overwhelming approval by the electorate does not impart scientific validity to a law; however, overwhelming approval by the electorate does require that public agencies enforce such measures. There are many examples of laws with questionable scientific or technical basis, with the recent experience with premarital testing for acquired immunodeficiency syndrome in Illinois being a prominent example of such. In any case, the point of our article was to explain how we have implemented Proposition 65, with its myriad problems, in a scientifically sound manner. Indeed, the focus of
A New Look at Homosexuality
Authors: Daniel D. Federman
Journal: New England Journal of Medicine (1971)

Sexual reproduction is crucial to the preservation of the race but irrelevant to that of the individual. In this sense, despite the privacy usually accorded its expression, sex behavior is ultimately impersonal — that is, the endocrine and other tissues specialized for procreation are seldom also necessary for survival of the individual. Since self-interest for survival is not involved, a matrix of instinctual and hormonal drive has evolved that ensures adequate numbers of offspring. As one ascends the scale from lower mammals to primates to man, this biologic infrastructure bears an increasingly important psychosexual component. Thus, an intact autonomic and . . .
Hematopoietic stem cell transplantation for core binding factor acute myeloid leukemia: t(8;21) and inv(16) represent different clinical outcomes
Authors: Yachiyo Kuwatsuka, Koichi Miyamura, Ritsuro Suzuki, Masaharu Kasai, Atsuo Maruta, Hiroyasu Ogawa, Ryuji Tanosaki, Satoshi Takahashi, Kyuhei Koda, Kazuhiro Yago, Yoshiko Atsuta, Takashi Yoshida, Hisashi Sakamaki, Yoshihisa Kodera
Journal: Blood (2009)
A Theoretic Analysis of the Effects of Dipole Eccentricity upon the Manifest Vectors, the Manifest QRS Loops and the Potential of the Central Terminal
Authors: MANUEL GARDBERG
Journal: Circulation (1954)

Assuming homogeneous conductivity and a limitless medium, a theoretic analysis accomplished by employing a model leads to the conclusion that dipole eccentricity produces a systematic error in the magnitude and direction of the instantaneous manifest vectors, the manifest QRS loops and the potential of the central terminal. Exaggeration of the electrical rotation of the heart and other electrocardiographic problems are discussed as possible manifestation of dipole eccentricity. Certain correlations applying to spatial vectorcardiography are made from simultaneous study of the theoretic back potential, the AP lead of the cube, and the potential of the central terminal.
Schizophrenia can and should be renamed
Authors: David G Kingdon, Yoshihiro Kinoshita, Farooq Naeem, Maged Swelam, Lars Hansen, Selveraj Vincent, Shanaya Rathod
Journal: BMJ (2007)

Lieberman and First make the case against renaming schizophrenia on the grounds that changing the term would not change the stigma attached to the underlying condition.1 Yet renaming is a key strategy used by marketing and public relations industries to improve image, alongside attitude change and …
AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein
Authors: Björn Steffen, Markus Knop, Ulla Bergholz, Olesya Vakhrusheva, Miriam Rode, Gabriele Köhler, Marcel-Philipp Henrichs, Etmar Bulk, Sina Hehn, Martin Stehling, Martin Dugas, Nicole Bäumer, Petra Tschanter, Christian Brandts, Steffen Koschmieder, Wolfgang E. Berdel, Hubert Serve, Carol Stocking, Carsten Müller-Tidow
Journal: Blood (2011)
Preservation of Normal Lung Regions in the Adult Respiratory Distress Syndrome
Authors: Richard J. Maunder, William P. Shuman, James W. McHugh, Stephen I. Marglin, John Butler
Journal: JAMA (1986)

In this report, we challenge the commonly held assumption that the adult respiratory distress syndrome (ARDS) is a homogeneous process associated with generalized and relatively uniform damage to the alveolar capillary membrane. We studied 13 patients with ARDS, comparing the pulmonary parenchymal changes seen by standard bedside chest roentgenograms with those seen by computed tomography of the chest. Three patients demonstrated generalized lung involvement by both radiologic techniques. In another eight patients, despite the appearance of generalized involvement on the standard chest x-ray film, the computed tomographic scans showed patchy infiltrates interspersed with areas of normal-appearing lung. Two patients showed patchy involvement by both techniques. The fact that ARDS spares some regions of lung parenchyma is useful knowledge in understanding the gas-exchange abnormalities of ARDS, the variable responsiveness to positive end-expiratory pressure, and the occurrence of oxygen toxicity. The problem of regional inhomogeneity should also be kept in mind when interpreting lung biopsy specimens or bronchoalveolar lavage fluid in patients with ARDS. (<i>JAMA</i>1986;255:2463-2465)
Novel Antipsychotics and the Neuroleptic Malignant Syndrome: A Review and Critique
Authors: Samia Hasan, Peter Buckley
Journal: American Journal of Psychiatry (1998)

OBJECTIVE: The authors' goal was to analyze reported cases of neuroleptic malignant syndrome in patients given clozapine and risperidone. METHOD: They assessed 19 cases of clozapine-induced neuroleptic malignant syndrome and 13 cases of risperidone-induced neuroleptic malignant syndrome against three criteria sets and against extent of exclusionary workup and then designated them as high or low probability of being neuroleptic malignant syndrome. RESULTS: Nine of the 19 cases of clozapine-related neuroleptic malignant syndrome and eight of the 13 cases of risperidone-related neuroleptic malignant syndrome were designated as having high probability of being neuroleptic malignant syndrome. The remainder were designated as having low probability because presentations were not linked to treatment or failed to meet criteria for the syndrome. CONCLUSIONS: Neuroleptic malignant syndrome can occur in patients given atypical antipsychotics and resembles "classical" neuroleptic malignant syndrome. However, side effect profiles overlap considerably with neuroleptic malignant syndrome criteria, and atypical antipsychotics may cause neurotoxicities unrelated to (but misattributed as) neuroleptic malignant syndrome. Insufficient evidence exists for "atypical" neuroleptic malignant syndrome with novel antipsychotics. (Am J Psychiatry 1998; 155:1113–1116)
Anti-CD22-MCC-DM1: an antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma
Authors: A G Polson, M Williams, A M Gray, R N Fuji, K A Poon, J McBride, H Raab, T Januario, M Go, J Lau, S-F Yu, C Du, F Fuh, C Tan, Y Wu, W-C Liang, S Prabhu, J-P Stephan, J-A Hongo, R C Dere, R Deng, M Cullen, R de Tute, F Bennett, A Rawstron, A Jack, A Ebens
Journal: Leukemia (2010)
Association of vascular risk factors with increasing glycemia even in normoglycemic subjects in an older Chinese population: the Guangzhou Biobank Cohort Study
Authors: G. Neil Thomas, Chao Qiang Jiang, Sarah M. McGhee, Wei Sen Zhang, Xiang Qian Lao, Mary Schooling, Peymane Adab, Tai Hing Lam, Kar Keung Cheng
Journal: Metabolism (2006)
93 Indoor exposure to formaldehyde at concentrations below 50 μg/m3 does not contribute to asthma development
Authors: P GORSKI, C PACZYNSKI, J STANKIEWICZ, B KOACINSKA, U RUTA, J GRUCHAA, A KRAKOWIAK, B SZULC, J JAKUBOWSKI, W HANKE
Journal: Journal of Allergy and Clinical Immunology (1996)
Cardiorespiratory fitness is an important risk factor
Authors: M. Beary, H. J. Wildgust
Journal: BMJ (2011)

Our research has shown that schizophrenia is associated with a 25 year reduction in life expectancy.1 The top four mortality risk factors were low fitness, hypertension, smoking, and diabetes. The World Health Organization identified these same top four risk factors in the general population.2 Blair reported that physical …
A piece of my mind. Liquid air
Authors: D. C. Weaver
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Day-care Setting for Intensive Chemotherapy May Raise Patients' Spirits, Lower Hospital Bills
Authors: Beverly Merz
Journal: JAMA (1987)

ADULT DAY CARE can provide an equally effective but less expensive alternative to hospitalization for patients undergoing intensive cancer chemotherapy, according to a study conducted by investigators at Memorial Sloan-Kettering Cancer Center in New York City. Richard J. Gralla, MD, reported in Atlanta at the annual meeting of the American Society of Clinical Oncology that he and his associates had conducted a prospective study in which 440 patients were randomized to receive chemotherapy either while hospitalized or in a day-care setting. All patients met certain criteria: they required professional care for at least four hours but for less than eight hours three days a week; they were enrolled in treatment protocols that usually required hospital admission; and they lived with a person who was willing to assist with home care or emergencies. From February 1984 through January 1986, 229 patients were assigned to day care, 211 to hospital care. A
Hyperlipemia and Arteriosclerosis
Authors: Vincent P. Dole, Enoch Gordis, Edwin L. Bierman
Journal: New England Journal of Medicine (1963)

TURBIDITY of blood plasma, if marked, is abnormal. Even at the peak of alimentary lipemia the plasma of an average healthy person shows no more than a faint to moderate milkiness. Those who are studying transport of fat in blood therefore look for the unusual person, the so-called "good producer" of chylomicrons.Although grateful to these subjects for supplying material, one cannot fail to become concerned with the consequences of their talent. Is hyperlipemia a benign abnormality, or does it reflect metabolic faults that will shorten life? Can blood vessels be damaged by an excess of circulating fat? More generally, . . .
Serum Thymidine Kinase 1 Activity in the Prognosis and Monitoring of Chemotherapy in Lung Cancer Patients: A Brief Report
Authors: Benjamin Nisman, Hovav Nechushtan, Haim Biran, Hadas Gantz-Sorotsky, Nir Peled, Simon Gronowitz, Tamar Peretz
Journal: Journal of Thoracic Oncology (2014)

Thymidine kinase 1 (TK1) is a metabolic enzyme involved in DNA synthesis. Most standard treatment protocols for lung cancer (LC) include cytotoxic agents, which are potential modulators of TK1. We aimed to assess the prognostic significance of serum TK1 activity and its role in monitoring chemotherapy in LC patients.TK1 activity was measured using the DiviTum (Biovica) assay in sera from 233 patients with non-small-cell lung cancer (NSCLC), 91 with small-cell lung cancer (SCLC), and 90 with benign lung disease.TK1 activity was significantly associated with age, performance status, and stage in NSCLC and with stage and weight loss in SCLC. In multivariate analysis, pretreatment TK1 activity, adjusted for performance status, stage, and weight loss, independently affected survival in NSCLC (relative risk =1.45, p = 0.031) and SCLC (relative risk = 2.49, p = 0.001). In NSCLC patients, adjusted elevated TK1 activity (>100 Du/L) at pretreatment was a significant predictor of treatment failure (odds ratio = 2.55, p = 0.01). A small (less than twofold) increase in TK1 activity after the first and second cycle of chemotherapy was significantly associated with treatment failure and poor overall survival.Elevated pretreatment serum TK1 activity was an independent, adverse prognostic factor, based on survival, in the two main histological types of LC. A small (less than twofold) increase in TK1 activity after the first and second cycle of chemotherapy was associated with treatment failure and poor overall survival.
Vaccine Information Pamphlets Here, But Some Physicians React Strongly
Authors: Marsha F. Goldsmith
Journal: JAMA (1992)

STARTING TODAY, pediatricians may want to provide more diversions in their reception rooms for young patients awaiting immunization. Children will probably have time to look through several picture books or build a fairly large house of blocks in the time it takes their parents to read one of the new federally mandated educational pamphlets about vaccines, according to several physicians familiar with the materials.  Three vaccine information pamphlets, known informally as VIPs, have been produced by the Immunization Division of the Centers for Disease Control (CDC), Atlanta, Ga. Their creation was mandated to satisfy one requirement of the National Childhood Vaccine Injury Act of 1986.  And now (April 15), health care providers who administer any of seven specified vaccines to a child must provide the parent or guardian with detailed information about the procedure.  Adults who are about to be immunized must also be fully informed. State and local health
The Patient With Multiple Alloantibodies-Reply
Authors: Ethel Patten
Journal: JAMA (1982)

<h3>In Reply.—</h3> We are grateful for the interest that Mr Issitt and Dr Tomasulo have taken in our report and welcome the opportunity to respond to their letter. The patient presented a complex serological picture, which was abbreviated in the case report. She was studied by two American Association of Blood Banks reference laboratories during a period of several months in 1978. There was a difference of opinion as to whether the presence of anti-Jk<sup>b</sup>could be proved conclusively. The high-frequency antibody was thought initially to be anti-Joseph, but ultimately its specificity could not be determined. Anti-Lewis<sup>a</sup>, anti-Lewis<sup>b</sup>, and an additional unidentified antibody were suspected. Two months after the delayed hemolytic transfusion reaction, an IgG autoantibody, reacting less strongly with Rh mull cells, developed. The exact cause of the delayed hemolytic transfusion reaction could not be determined, and the reference laboratory recommended that transfusion be restricted to
Treatment of mild and moderate hypertension
Authors: B. Isaacs
Journal: BMJ (1981)

Evidence from the Royal College of General Practitioners cohort study points to the progestogen dosage in combined preparations as being more important in this regard.'Moreover, a lack of association with oestrogen dosage was found.In addition, a positive correlation between the risk of arterial disease and progestogen dosage has been demon-strated3 and this, in part at least, may be due to the effect on blood pressure.
Project 75
Authors: Andrew L. Thomas
Journal: JAMA (1971)

The task of increasing the enrollment of minority students in US medical schools is, superficially, a formidable problem. However, upon careful analysis, the problem is seen to be distinctly solvable<i>if</i>certain considerations are taken into account. Obviously there are many factors that have, in the past, prohibited many minority students from pursuing medical careers and made it difficult for those who managed to complete the curriculum. The most important factors operative along the pathway to a medical career have been explored in detail by the Association of American Medical Colleges' Task Force.<sup>1</sup>I commend that document to you as one of tremendous importance as we seek to increase the number of minority physicians in this country. In the Task Force Report,<sup>1</sup>several obstacles were identified which face minority students interested in medical careers. Recommendations were offered which provide real possibilities for overcoming many of these barriers. Among
NHS care in England is still not centred on patients
Authors: Zosia Kmietowicz
Journal: BMJ (2005)

Surveys involving more than a million NHS patients in England show that although certain areas of health care, such as waiting times, cancer care, and coronary heart disease, have improved in recent years, patient centred care is still not routine. Results of the 15 surveys done between 1998 and 2005 by the Picker Institute, which runs the national patient survey programme for the NHS in England, show that patients still want more information about their treatment and to be involved more in decisions about their care. They …
Brucellosis Linked to Mexican Cheese
Authors: Mark R. Eckman
Journal: JAMA (1975)

Three cases of brucellosis occurred, two acute cases and one chronic, all of which likely resulted from the ingestion of fresh cheese containing Brucella melitensis. A history of patients with illness suggestive of brucellosis should include details about food ingested recently in addition to the usual questions about travel and occupation. As the US domestic-animal disease comes under better control, and travel to Mexico, Spain, and Italy increases, it seems likely that human disease caused by B melitensis will become relatively more common.
Bronchodilating Effect of Intravenous Magnesium Sulfate in Bronchial Asthma
Authors: Hiroshi Okayama
Journal: JAMA (1987)

The bronchodilating effect of magnesium sulfate (MgSO4) was studied in ten asthmatic patients with mild attacks. In five patients, 0.5 mmol/min of MgSO4 was administered intravenously for 20 minutes, and the time courses of respiratory resistance, forced vital capacity, and forced expiratory volume at 1 s were studied. In another five patients, MgSO4 dose-response curves were obtained. Soon after administration began, MgSO4 relieved bronchoconstriction in a dose-dependent manner. Maximum responses (mean +/- SE) of respiratory resistance, forced vital capacity, and forced expiratory volume were 71% +/- 3%, 117% +/- 5%, and 118% +/- 1% of initial values, respectively, and were similar to the effects of additional albuterol inhalation. The infusion of MgSO4 also improved dyspnea and piping rales in three other asthmatic patients with a severe attack. We conclude that intravenous infusion of MgSO4 produces a rapid and marked bronchodilation in both mild and severe asthma and may be a unique bronchodilating agent.
Synergistic inhibition of breast cancer by co-delivery of VEGF siRNA and paclitaxel via vapreotide-modified core–shell nanoparticles
Authors: Qiang Feng, Min-Zhi Yu, Jian-Cheng Wang, Wen-Jie Hou, Ling-Yan Gao, Xiao-Fei Ma, Xi-Wei Pei, Yu-Jie Niu, Xiao-Yan Liu, Chong Qiu, Wen-Hao Pang, Li-Li Du, Qiang Zhang
Journal: Biomaterials (2014)
The effect of liver dysfunction on colchicine pharmacokinetics in the rat
Authors: Jonathan A. Leighton, Michael K. Bay, Alma L. Maldonado, Raymond F. Johnson, Steven Schenker, K. V. Speeg
Journal: Hepatology (1990)

Recent work has shown that colchicine may benefit patients with primary biliary or alcoholic cirrhosis. However, very little is known about its pharmacokinetics in the presence of impaired liver function. To study this we examined the effects of three models of experimental liver dysfunction and one of cytochrome P–450 inhibition on colchicine elimination in the rat. The models of experimental liver dysfunction included bile duct ligation (with sham–operated controls), α–naphthylisothiocyanate–induced intrahepatic cholestasis and galactosamine–induced diffuse hepatocelluar necrosis. The control group had a colchicine clearance of 77.33 ml/min. kg ± 8.27 ml/min kg, a half–life of 16.68 min ± 0.97 min and a volume of distribution of 1.84 L/kg ± 0.15 L/kg. Cimetidine administration, 120 mg/kg intraperitoneally 15 min before colchicine administration, caused clearance to decrease by 32% (p &lt; 0.05) and half–life to increase by 38% (p &lt; 0.05). Volume of distribution did not change. At 48 hr after bile duct ligation, colchicine clearance decreased by 84% (p &lt; 0.05), terminal half–life increased to 513.7 min ± 106.6 min (p &lt; 0.05) and volume of distribution increased by 175% (p &lt; 0.05). Colchicine pharmacokinetics in sham–operated rats were not statistically different from the above mentioned controls. After α–naphthylisothiocyanate administration, colchicine clearance decreased by 55% (p &lt; 0.05), the halflife increased by 56% (p &lt; 0.05) and the volume of distribution decreased by 30% (p &lt; 0.05). After administration of galactosamine, 1,000 mg/kg, colchicine clearance decreased by 62% (p &lt; 0.05), half–life increased to 144.72 min ± 35.30 min (p &lt; 0.05) and volume of distribution increased by 124% (p &lt; 0.05). These data show that experimental hepatic injury in the rat significantly impairs colchicine pharmacokinetics. They also support the hypothesis that the liver is a major route of colchicine elimination.
Autologous T-cell Therapy for Cytomegalovirus as a Consolidative Treatment for Recurrent Glioblastoma
Authors: Andrea Schuessler, Corey Smith, Leone Beagley, Glen M. Boyle, Sweera Rehan, Katherine Matthews, Linda Jones, Tania Crough, Vijayendra Dasari, Kerenaftali Klein, Amy Smalley, Hamish Alexander, David G. Walker, Rajiv Khanna
Journal: Cancer Research (2014)

Glioblastoma multiforme (GBM) is one of the most aggressive human brain malignancies. Even with optimal treatment, median survival is less than 6 months for patients with recurrent GBM. Immune-based therapies have the potential to improve patient outcome by supplementing standard treatment. Expression of human cytomegalovirus (CMV) antigens in GBM tissues provides the unique opportunity to target viral antigens for GBM therapy. Here, we report findings of a formal clinical assessment of safety and potential clinical efficacy of autologous CMV-specific T-cell therapy as a consolidative treatment for recurrent GBM. From a total of 19 patients with recurrent GBM, CMV-specific T cells were successfully expanded from 13 patients (68.4%), 11 of whom received up to four T-cell infusions. Combination therapy based on T-cell infusion and chemotherapy was well tolerated, and we detected only minor adverse events. The overall survival of these patients since first recurrence ranged from 133 to 2,428 days, with a median overall survival of 403 days. Most importantly, 4 of 10 patients that completed the treatment remained progression free during the study period. Furthermore, molecular profiling of CMV-specific T-cell therapy from these patients revealed distinct gene expression signatures, which correlated with their clinical response. Our study suggests that a combination therapy with autologous CMV-specific T cells and chemotherapy is a safe novel treatment option and may offer clinical benefit for patients with recurrent GBM.