tbuckley/cabot-search huggingface dataset:
Buruli Ulcer in New York City
Authors: Sonia D. Lindo
Journal: JAMA (1974)

Buruli ulcer, or infection with<i>Mycobacterium ulcerans</i>, is a chronic destructive lesion that is endemic in some parts of tropical Africa, New Guinea, Malaysia, and Australia, but it has not been acquired or transmitted in the United States. We report an example that appeared in a Nigerian physician while he was working in New York City. (<i>JAMA</i>228:1138-1139, 1974)
Distribution of Acid Mucopolysaccharides in Inner and Outer Layers of Bovine Aorta
Authors: GERALD S. BERENSON
Journal: Circulation Research (1959)

Bovine aortas were separated into 2 layers, an inner layer composed chiefly of intima and an outer layer composed of adventitia and most of the media. A greater concentration of acid mucopolysaccharides, especially of the chondroitin sulfuric acid group, was found in the inner layer of the aorta.
US survey shows extent of research misconduct
Authors: Owen Dyer
Journal: BMJ (2005)

A third of US scientists have engaged in serious research misconduct in the past three years, according to a survey published in the journal Nature (2005;435: 718-9).

The findings are based on a postal survey answered by more than 3200 scientists around the United States, all of whom did work funded by the National Institutes of Health. They were asked if they had committed any of a list of 33 transgressions of research standards.

Ten of these transgressions were identified as serious by a panel of members of research ethics boards. …
Cardiac Magnetic Resonance With Edema Imaging Identifies Myocardium at Risk and Predicts Worse Outcome in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome
Authors: Subha V. Raman, Orlando P. Simonetti, Marshall W. Winner, Jennifer A. Dickerson, Xin He, Ernest L. Mazzaferri, Giuseppe Ambrosio
Journal: Journal of the American College of Cardiology (2010)
Value of Blood Transfusion in Malignant Diphtheria
Authors: I. Pugh, O. S. Williams
Journal: BMJ (1941)

MRITISHin the control group (Table II), it becomes clear that certain typical changes occurred after the end of the treatment.Thus about four months after the treatment finished con- siderable deterioration had occurred, consisting in particu- lar of disappearance of the improvement obtained during the treatment, and also of the appearance of some new cases of deterioration.This indicates that in some cases
HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
Authors: Michael A. Kalchman, H. Brook Koide, Krista McCutcheon, Rona K. Graham, Kerrie Nichol, Kazutoshi Nishiyama, Parsa Kazemi-Esfarjani, Francis C. Lynn, Cheryl Wellington, Martina Metzler, Y. Paul Goldberg, Ichiro Kanazawa, R. Dan. Gietz, Michael R. Hayden
Journal: Nature Genetics (1997)
The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas1
Authors: David E. Gerber, Stuart A. Grossman, Michel Zeltzman, Michele A. Parisi, Lawrence Kleinberg
Journal: Neuro-Oncology (2006)

Temozolomide (TMZ) administered daily with radiation therapy (RT) for six weeks, followed by adjuvant TMZ for six months, has become standard therapy for patients with glioblastoma multiforme (GBM). After several newly diagnosed patients at our institution developed severe (grade 3-4), prolonged thrombocytopenia, we conducted a retrospective review to define the incidence, depth, and duration of thrombocytopenia associated with this therapy. We reviewed the medical records and laboratory data of all adult patients with newly diagnosed high-grade gliomas who started treatment with this regimen between June 2004, when the regimen was first used at our institution, and August 2005. Of the 52 patients who met the criteria for this review, grade 3-4 thrombocytopenia occurred in 10 (19%; 95% CI, 10%-33%). In eight patients, the thrombocytopenia was attributable to concurrent daily TMZ and RT. The median duration of grade 3-4 thrombocytopenia was 32 days (range, 1-389 days). Five patients (10%) required platelet transfusions, two (4%) have required continued biweekly platelet transfusions for over six months, and nine (17%) discontinued therapy because of thrombocytopenia. Grade 3-4 thrombocytopenia occurred in 25% of women and 14% of men. Grade 3-4 neutropenia and anemia were noted in 10% and 8% of patients, respectively, and were not clinically significant. Between 15% and 20% of our newly diagnosed patients receiving TMZ and RT developed severe (grade 3-4) and potentially irreversible thrombocytopenia. The factors that predispose patients to this toxicity have yet to be determined. This toxicity should be considered when (1) prescribing this regimen to patient populations where a clinical benefit has yet to be shown, (2) contemplating empirical escalations of the dose or duration of TMZ, or (3) combining it with other potentially myelosuppressive therapies.
Recent advances: Accident and emergency medicine
Authors: S. A Stahmer
Journal: BMJ (1998)

Emergency medicine is rapidly evolving as a medical specialty. It provides immediate and universal care to over 90 million patients a year in the United States alone. In addition to life saving treatment, the emergency department provides a safety net, giving unrestricted care to people with little or no access to other types of health care. Recent developments reflect the varied nature of emergency medicine. These include improvements in emergency management of acute cardiac ischaemia, identification of victims of domestic violence, and the use of diagnostic tools such as ultrasound examination by specialists in emergency medicine.

Topics were chosen after reviewing articles published during the past two years in those peer reviewed journals commonly referred to by specialists in emergency medicine. Selection was based on the number of quality studies published on a particular topic and the topic's actual or potential impact on clinical practice in emergency medicine. A Medline search was performed using the terms cardiac markers, domestic violence, ultrasound, and emergency medicine.

In the United States alone, over six million patients each year present to the emergency department with chest pain. The goals of the doctor are to identify rapidly those patients who are candidates for thrombolytic treatment; to differentiate between patients with chest pain caused by acute coronary ischaemia and chest pain from other causes in order to avoid unnecessary admission to hospital; and to stratify those patients with possible ischaemic chest pain into risk groups.

In addition to the routine medical history, physical examination, and 12 lead electrocardiography, the specialist in emergency medicine now has access to a growing number of ancillary tests and technologies that can help in the management of patients with chest pain. Those which seem particularly promising include new markers of cardiac ischaemia, stress testing, and acute perfusion imaging with technetium-99m labelled …
Neuropsychological pattern during gluten free diet (GFD) in elderly coeliac patients
Authors: S. Casella, B. Zanini, F. Lanzarotto, F. Caselani, A. Magni, G. Romanelli, A. Lanzini
Journal: Gut (2011)

<h3>Introduction</h3> Previous studies suggested a correlation between celiac disease (CD) and cognitive impairment, but only few described these characteristics in the elderly, all based on a small number of patients or as case-reports. <h3>Methods</h3> The aim of this study was to analyze the neuropsychological pattern in CD patients aged ≤ 65 years by comparison with a population of patients with GI disorders different than CD. We retrospectively identified a cohort of CD elderly patients attending our CD Clinic, all on GFD for a minimum of 12 months (n=18 Group A). We also identified sex and age matched (±5 years) control patients (n=18 Group B). Patients and controls were submitted to neuropsychological tests including: BADL (Basic Activity Daily Living); IADL (Instrumental Activity Daily Living); Barthel Index; GDS (Geriatric Depression Scale); MMSE (Mini Mental Test Examination); Trail Making Test (TMT A, B, B-A); Raven9s matrices; Digit Symbol; Semantic and Phonemic fluency; Rey list; Verbal Span; Ideomotor and Buccofacial apraxia. <h3>Results</h3> There were no significant differences of laboratory parameters, thyroid profile, vitamin B12 and folate level in the two groups and all the patients were TPHA negative. The differences of neuropsychological tests between the two cohorts are summarised in table 1. All tests indicated that cognitive performances were worse (except for Rey list) in group A than group B. <h3>Conclusion</h3> CD elderly patients have worse cognitive performance than sex and age-matched subjects, despite being on GFD for a minimum of 12 months. The attention deficiency, semantic fluency, visuo-spatial, executive ability impairment and ideo-motor apraxia is likely to be related to thalamic, frontosubcortical, frontotemporal and cerebellar impairment. The neuropsychological pattern of elderly CD celiac patients on GFD has the characteristics of vascular cognitive impairment.
Pain and Perfectionism — The Physician and the “Pain Patient”
Authors: Howard M. Spiro
Journal: New England Journal of Medicine (1976)

Pain more than "health" has been a central concern of the physician as his guide to internal disorders, for to patient and physician alike, pain usually means disease or disorder of some kind. Yet, talk with a philosopher who has abdominal pain, and you will find how difficult it is for one person to tell another of his visceral sensations, and what a burden it is for the physician to decide which pain is real and which imaginary, which pain gets antacids and which an operation, and which puts the patient to bed and which sends him off to a . . .
Transgastric in vivo histology in the peritoneal cavity using miniprobe-based confocal fluorescence microscopy in an acute porcine model
Authors: S. Delius, H. Feussner, D. Wilhelm, A. Karagianni, J. Henke, R. Schmid, A. Meining
Journal: Endoscopy (2007)

See also: Commentaire de travail de S. von Delius et al., pp. 407Endoscopy 2007; 39(05): 483-483DOI: 10.1055/s-0032-1306963
New Hemorrhagic Fever Virus
Authors: Joan Stephenson
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increased expression of the CD80 accessory molecule by alveolar macrophages in asthmatic subjects and its functional involvement in allergen presentation to autologous TH2 lymphocytes
Authors: Samuele E. Burastero, Zulma Magnani, Claudio Confetti, Laura Abbruzzese, Susanna Oddera, Piero Balbo, Giovanni A. Rossi, Emanuele Crimi
Journal: Journal of Allergy and Clinical Immunology (1999)
Use of maltose hydrolysis measurements to characterize the interaction between the aqueous diffusion barrier and the epithelium in the rat jejunum.
Authors: M D Levitt, C Fine, J K Furne, D G Levitt
Journal: Journal of Clinical Investigation (1996)

Rates of intestinal absorption and surface hydrolysis are determined by the interaction of two barriers: poorly stirred fluid adjacent to the mucosa, and the epithelial cell. These two barriers commonly are modeled as a fixed, flat layer of epithelium covered by a fixed thickness of unstirred fluid. To more accurately simulate these barriers in a villous mucosa, maltase activity (measured in vitro) was distributed over an anatomically correct model of rat jejunal villi. We then determined what interaction of the aqueous and epithelial barriers best predicted in vivo maltose hydrolysis rates measured over a broad range of infusate concentrations. Hydrolysis was accurately predicted by a model in which unstirred fluid extended from 20 microm over the villous tips throughout the intervillous space. In this model, the depth of diffusion into the intervillous space is inversely proportional to the efficiency of epithelial handling of the solute. As a result, both the aqueous barrier and the functional surface area are variables rather than constants. Some implications of our findings (relative to the conventional model) include: higher predicted Vmax, efficient handling of low concentrations of a solute at the villous tips while high concentrations must penetrate thick aqueous barriers, and sensitive regulation of transport rates via ease of access to the intervillous space.
Future Trends in Inflammation
Authors: B. Vernon-Roberts
Journal: Annals of the Rheumatic Diseases (1975)

It is divided into sections dealing with prostaglandins in inflammation, cellular events in inflammation, mechanism of anti-inflammatory drugs, general aspects of in- flammation, immunological aspects of inflammation, and current research trends in chronic inflammation.Most of these sections begin with a brief introduction, and close with a good review of the field by the chairman for each session of the meeting.The discussion is published verba- tim, and is particularly notable for the aptly pungent comments by a Dr. Vinegar.In common with many other books containing collected conference papers, it all adds up to a curate's egg, the standard varying from some highly interesting and informative accounts of current work on the one hand to variably restructured accounts of work previously published (albeit much of it of a very high standard) on the other.There are also a small number of very brief abstracts.I feel that the editors should have risked offending some of the authors by in- cluding at length only material which was new, and thereby also justifying the use of the misleading title.One does not Furniture', 'Hoists and Walking Aids', 'Disabled Child'.
Beta-adrenergic stimulation of the failing ventricle: a double-blind, randomized trial of sustained oral therapy with prenalterol.
Authors: G S Roubin, C Y Choong, S Devenish-Meares, N N Sadick, P J Fletcher, D T Kelly, P J Harris
Journal: Circulation (1984)

Eleven patients with severe left ventricular impairment (mean ejection fraction 24%) and moderate impairment of exercise tolerance underwent a double-blind, placebo-controlled, cross-over trial of the orally administered beta-agonist prenalterol. Exercise hemodynamics and tolerance were measured during bicycle and treadmill exercise after 2 weeks of therapy with placebo or prenalterol. Cardiac index, ejection fraction, and stroke work index were not improved and exercise duration and peak oxygen consumption were not significantly different during the two treatments. During prenalterol treatment heart rate during exercise was consistently reduced. These results show that prolonged therapy with prenalterol does not improve hemodynamics or exercise tolerance and is associated with a diminished heart rate response to exercise.
IMPACT OF FLOW AND LEFT VENTRICULAR SYSTOLIC FUNCTION ON OUTCOME OF PATIENTS WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION AND LOW GRADIENT SEVERE AORTIC VALVE STENOSIS UNDERGOING AORTIC VALVE REPLACEMENT
Authors: Vasileios Kamperidis, Philippe J. van Rosendael, Arnold C.T. Ng, Spiros Katsanos, F. van der Kley, Philippe Debonnaire, Emer Joyce, Georgios Sianos, Nina Ajmone Marsan, Jeroen Bax, Victoria Delgado
Journal: Journal of the American College of Cardiology (2014)
Long-Term Glycemic Control and Neurological Function in IDDM Patients
Authors: David R McCance, A Brew Atkinson, David R Hadden, Laurence Kennedy
Journal: Diabetes Care (1993)

To examine the relationship between sensory modalities of neurological function and antecedent glycemic control in IDDM patients.Examinations were conducted on 220 IDDM patients (age at onset < 25 yr, duration < 18 yr) for the presence or absence of the right or left ankle reflex and determination of vibration perception threshold at each medial malleolus and great toe using biothesiometry. These parameters were related to the concurrent HbA1 and to a mean of serial measurements (mean HbA1) over the previous 6 yr.Ankle reflexes were absent in 39 (right ankle) and 41 (left ankle) patients, respectively. Mean (right + left) ankle and toe VPTs were 8.7 +/- 3.6 and 6.3 +/- 4.2 (mean +/- SD) (arbitrary units), respectively. Both the mean and concurrent HbA1 were significantly different in patients with absent ankle reflexes (11.6 +/- 1.9 and 12.2 +/- 2.8%, respectively) compared with present ankle reflexes (10.3 +/- 1.7, 10.3 +/- 2.1%) (P < 0.0001). Similarly, a present ankle reflex was related to mean HbA1 arbitrarily divided into groups < 10, 10-12, > 12% (P = 0.0009). In contrast, mean ankle VPT (8.0 +/- 2.2, 8.8 +/- 3.1, and 10.3 +/- 6.2) and toe VPT (5.5 +/- 2.2, 6.1 +/- 2.9, and 8.5 +/- 8.2) did not increase significantly with poor glycemic control (P > 0.05). Age, right ankle reflex, retinopathy, 24-h urinary albumin excretion rate, and erect systolic blood pressure were the only independent variables predicting the toe VPT using linear regression analysis.These findings support a role for glycemic control in neurological dysfunction in IDDM patients, but also suggest that other unknown factors may be involved.
Case 9-1973
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, William F. Enneking, Walter G. J. Putschar
Journal: New England Journal of Medicine (1973)

Presentation of CaseAn 18-month-old girl was admitted to the hospital because of a bone lesion.The child was the product of a normal pregnancy and delivery of a mother aged 35 years. The birth weight was 3.3 kg. The child was well until four weeks before admission, when she fell from her crib, without sustaining obvious injury. One week later her mother observed that she limped and took her to a physician, who made a diagnosis of otitis and prescribed ampicillin. Diarrhea developed, and ampicillin was omitted after four days. Two weeks before entry the child became listless and . . .
Can the level of CD52 expression on Sézary cells be used to predict the response of Sézary syndrome to alemtuzumab?
Authors: Iolanda Conde Fernandes, Marta Gonçalves, Maria dos Anjos Teixeira, Cristina Gonçalves, Jorge Coutinho, Manuela Selores, Rosário Alves, Margarida Lima
Journal: Journal of the American Academy of Dermatology (2012)
Repeated courses of rituximab in chronic ITP: Three different regimens
Authors: Aisha Hasan, Marc Michel, Vivek Patel, Roberto Stasi, Susanna Cunningham‐Rundles, John P. Leonard, James Bussel
Journal: American Journal of Hematology (2009)

This study investigated responses to retreatment with rituximab in chronic immune thrombocytopenic purpura (ITP) patients. Treatment with rituximab in chronic ITP patients induces long-lasting responses in approximately 30% of patients but even these patients may relapse. Twenty patients who had achieved a response to rituximab and relapsed were retreated with rituximab (375 mg/m(2)x 4); this data was analyzed retrospectively. Subsequently, 16 patients were prospectively randomized to receive rituximab with cyclophosphamide, vincristine and prednisone (R-CVP) or double dose rituximab (DDR). Retreatment with standard dose rituximab demonstrated responses similar to initial rituximab treatment in 15 of 20 patients. Neither of the two more intensive regimens (R-CVP, DDR) induced responses in any patient who had previously failed to respond to rituximab nor induced substantially longer-lasting responses among previous responders. No additional toxicity was noted with the DDR regimen, whereas R-CVP was not well tolerated. These results suggest that retreatment with standard dose rituximab induces similar responses in 75% of previously responding patients and is well tolerated. Neither combining rituximab with CVP nor doubling the dose of rituximab increased the response rate.
Conference of State Medical Examining and Licensing Boards.
Authors: John H. Rauch
Journal: JAMA (1893)

—The third annual meeting of the Conference of State Medical Examining and Licensing Boards will be held in Milwaukee, Wis., June 7, 1893. The following subjects will be discussed, and we will be glad to have you notify us of your intention to prepare a paper on some one of them, and take part in the discussion of any or all of them. We will also be glad to have you suggest, in advance of the meeting, other subjects you may think it desirable to discuss. The Evolution of State Medical Examining and Licensing Boards. Their present and prospective influence in elevating the moral and intellectual tone of the profession. Composition of Boards. The desirable number of members. The desirable appointing power. The advantages and disadvantages of separate boards representing the different schools of practice. Provisions of the Various State Laws. Should the possession of a diploma from a
Informed Consent by Well-Nigh Abject Adults
Authors: Drummond Rennie
Journal: New England Journal of Medicine (1980)

Society has become increasingly restless with the paternalistic attitudes of professional experts. The courts, reflecting the values of society, have increasingly reinforced the principle of self-determination as enunciated by Cardozo: "Every human being of adult years and sound mind has a right to determine what shall be done with his own body."1 Physicians are consultants to patients, but patients, not physicians, must finally decide for themselves where their best interests lie. The ordinary patient, whose "dependence upon the physician for information affecting his well-being, in terms of contemplated treatment, is wellnigh abject,"2 cannot possibly make a reasoned decision without being . . .
Hazards of Alkaline Laundry Detergents
Authors: H. W. Gerarde
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The purpose of this letter is to alert physicians to dangers associated with the accidental ingestion, by small children, of some nonphosphate highly alkaline laundry detergents. In many parts of the country these new washing agents will replace phosphate detergents which have been used for years and have an excellent record of safety in the home. The FDA, aware of the hazards of certain of these detergents, has announced that improved labeling will be required on a number of them. Unfortunately, however, children under 5 years of age cannot read, and since these nonphosphate cleaners will be placed where they are most convenient—usually within easy reach of youngsters—we can expect an increase in injury from ingestion and eye and skin irritations. In recent years, approximately 3,000 children ingested some household detergent or cleaner annually. According to Jensen, this figure represents only one sixth to one eighth of