Granulomatous Pulmonary Lesions in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and Pneumocystis carinii Infection
Authors: Walter Blumenfeld
Journal: Annals of Internal Medicine (1988)

Brief Reports15 September 1988Granulomatous Pulmonary Lesions in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and Pneumocystis carinii InfectionWalter Blumenfeld, MD, Nesli Basgoz, MD, William F. Owen Jr., MD, Drago M. Schmidt, MDWalter Blumenfeld, MDSearch for more papers by this author, Nesli Basgoz, MDSearch for more papers by this author, William F. Owen Jr., MDSearch for more papers by this author, Drago M. Schmidt, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-6-505 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPneumocystis carinii is the commonest opportunistic infection in patients with the acquired immunodeficiency syndrome (AIDS). Its clinical and pathologic features have been well described (1-3). We describe two patients with atypical granulomatous pulmonary manifestations of P. carinii. Both patients had initial episodes of P. carinii pneumonia and were treated. They subsequently received zidovudine and aerosolized pentamidine.Case 1A 38-year-old man with a 6-month history of AIDS presented with 1 week of nausea, fever, slight cough, and dyspnea. The patient had been treated for cytomegalovirus retinitis with ganciclovir, which was discontinued because of severe neutropenia. At the same time, he...References1. EngelbergLernerTapper LCM. Clinical features of Pneumocystis pneumonia in the acquired immune deficiency syndrome. Am Rev Respir Dis. 1984;130:689-94. MedlineGoogle Scholar2. KovacsHiemenzMacher JJA. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med. 1984;100:663-71. LinkGoogle Scholar3. PetersPrakash SU. Pneumocystis carinii pneumonia: review of 53 cases. Am J Med. 1987;82:73-8. CrossrefMedlineGoogle Scholar4. KovacsGillSwan JVJ. Prospective evaluation of a monoclonal antibody in diagnosis of Pneumocystis carinii pneumonia. Lancet. 1986;2:1-3. CrossrefMedlineGoogle Scholar5. GillEvansStockParrilloMasurKovacs VGFJHJ. Detection of Pneumocystis carinii by fluorescent-antibody stain using a combination of three monoclonal antibodies. J Clin Microbiol. 1987;25:1837-40. CrossrefMedlineGoogle Scholar6. Rahimi S. Disseminated Pneumocystis carinii in thymic alymphoplasia. Arch Pathol. 1974;97:162-5. MedlineGoogle Scholar7. GrimesLaPookBarWassermanDwork MJMHA. Disseminated Pneumocystis carinii infection in a patient with acquired immunodeficiency syndrome. Hum Pathol. 1987;18:307-8. CrossrefMedlineGoogle Scholar8. SchinellaBredaHammerschlag RSP. Otic infection due to Pneumocystis carinii in an apparently healthy man with antibody to the human immunodeficiency virus. Ann Intern Med. 1987; 106:399-400. LinkGoogle Scholar9. CoulmanGreeneArchibald CIR. Cutaneous pneumocystosis. Ann Intern Med. 1987;106:396-8. LinkGoogle Scholar10. EngBishburgSmith RES. Evidence for destruction of lung tissues during Pneumocystis carinii infection. Arch Intern Med. 1987;147:746-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Veterans Administration Medical Center, University of California; and St. Luke's Hospital, San Francisco, California. For current author addresses, see end of text. 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Sparling, MD, Sunny R. Dong, MApSc, MD, Csaba Hegedus, MD, David R. Burdge, MD 15 September 1988Volume 109, Issue 6Page: 505-507KeywordsAIDSLesionsMonoclonal antibodiesNauseaNeutropeniaOpportunistic infectionsPneumocystisPneumoniaPulmonary diseasesRetinitis Issue Published: 15 September 1988 PDF DownloadLoading ...