tbuckley/cabot-search huggingface dataset:
Renal artery stenosis: Authors' reply
Authors: A H Choudhri, J G F Cleland, P C Rowlands, T L Tran, M McCarty, M A O Al-Kutoubi
Journal: BMJ (1991)

SIR, -Dr A H Choudhri and colleagues unfor- tunately give no details of the radiographic projections used to image the renal arteries.'It would seem likely that the renal arteries were imaged only in a single anteroposterior projection.Anatomically the renal arteries arise from the anterior quadrants of the aorta, with the right renal artery usually arising more anteriorly than the left.2A single conventional anteroposterior projection done in conjunction with an aortic flush will provide inadequate visualisation of the origins of the renal artery, particularly on the right.The recommended projection is the 250 right posterior oblique, which throws both renal arteries, and particularly their origins, into profile.3It has been our experience of renal artery imaging using digital subtraction angiography that without the use of this oblique projection stenoses may be missed, resulting in the under- reporting of proximal lesions.
THE DELIVERY OF THE LENS FOR THE EXTRACTION OF CATARACT; IRRIGATION OF THE ANTERIOR CHAMBER, AND THE FIRST TOILET OF THE WOUND.
Authors: L. WEBSTER FOX
Journal: JAMA (1907)

The second stage toward the successful completion in cataract operations depends, first, on the length and character of the corneal incision; second, on the laceration of the capsule or the removal of the lens within its capsule through the opening in the cornea. The importance of the amplitude of the incision is so well known to all ophthalmic surgeons that, in his symposium, Dr. Weeks has undertaken to embellish this part of our subject with the care and precision which characterize all his writings on ophthalmology. Dr. E. E. Landolt of Paris has recently written an historical review of all the work done on this subject in a monograph of 130 pages.<sup>1</sup>So, with Dr. Weeks on this side of the Atlantic and Dr. Landolt on the other, the ophthalmic world will be made thoroughly conversant with all that can be said or written on that delicate incision in
Abstract 14480: Synthetic Smooth Muscle Cells are Derived from Multipotent Vascular Stem Cells Instead of Contractile Smooth Muscle Cells
Authors: Zhenyu Tang, Aijun Wang, Zhiqiang Yan, Julia Chu, Song Li
Journal: Circulation (2011)

Background: In the past few decades, it is generally believed that the de-differentiation of contractile SMCs results in proliferative synthetic SMCs upon vascular injury. However, the heterogeneou...
The dapsone hypersensitivity syndrome occurring in a patient with dermatitis herpetiformis
Authors: K.E. McKenna, J. Robinson
Journal: British Journal of Dermatology (1997)

Journal Article The dapsone hypersensitivity syndrome occurring in a patient with dermatitis herpetiformis Get access K.E. McKenna, K.E. McKenna Departments of Dermatology, Craigavon Area Hospital Group Trust, Craigavon, Portadown BT63 5QQ, Northern Ireland, U.K. Search for other works by this author on: Oxford Academic Google Scholar J. Robinson J. Robinson Departments of General Medicine, Craigavon Area Hospital Group Trust, Craigavon, Portadown BT63 5QQ, Northern Ireland, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 4, 1 October 1997, Pages 657–658, https://doi.org/10.1111/j.1365-2133.1997.tb03814.x Published: 01 October 1997
The associations of high-density lipoprotein subclasses with insulin and glucose levels, physical activity, resting heart rate, and regional adiposity in men with coronary artery disease: The stanford coronary risk intervention project baseline survey
Authors: Paul T. Williams, William L. Haskell, Karen M. Vranizan, Ronald M. Krauss
Journal: Metabolism (1995)

We used nondenaturing polyacrylamide gradient gel electrophoresis to examine the associations of high-density lipoprotein (HDL) subclasses with adiposity, physical activity, resting heart rate (an indicator of sympathetic drive), and plasma insulin and glucose levels in 97 men with angiographically documented coronary artery disease. These men neither smoked nor used medications known to affect lipoproteins. The absorbency of protein stain was used as an index of mass concentrations at intervals of 0.01 nm within five HDL subclasses: HDL3c (7.2 to 7.8 nm), HDL3b (7.8 to 8.2 nm), HDL3a (8.2 to 8.8 nm), HDL2a (8.8 to 9.7 nm), and HDL2b (9.7 to 12 nm). HDL peak diameter was determined from the predominant peak of the HDL particle distribution when plotted against particle diameter. Four men who were non—insulin-dependent diabetics as defined by a fasting glucose exceeding 140 mg/dL had significantly higher plasma HDL3b levels and significantly smaller HDL peak diameters than nondiabetic men, and were therefore excluded from further analyses. In the remaining 93 nondiabetic men, plasma HDL3b levels correlated positively with indices of truncal obesity (waist to hip ratio and subscapular skinfold), whereas plasma HDL2b levels correlated negatively with indices of total adiposity (body mass index [BMI]) and truncal obesity (subscapular and abdominal skinfold). Fasting plasma insulin levels correlated negatively with HDL3a, HDL2a, and HDL2b. Obesity significantly affected the relationships of resting heart rate with insulin and HDL subclasses. In heavier men (BMI > 25.8 kg/m2) but not in the less-obese men (BMI < 25.8 kg/m2), resting heart rate was negatively correlated with HDL3a, HDL2a, and HDL2b levels and HDL peak diameter and positively correlated with fasting plasma insulin concentrations. Although the reported physical activity in heavier men also correlated with HDL3a, HDL2a, and resting heart rate, the associations of resting heart rate with HDL3a, HDL2a, and HDL2bcould not be attributed to activity level. These analyses suggest that the influences of plasma insulin, regional adiposity, physical activity, and resting heart rate on HDL involve specific HDL subclasses. In the presence of increased adiposity, sympathetic drive and physical inactivity may reduce levels of larger HDL and the peak diameter of the major HDL subspecies.
Clearing the way to implantation
Authors: Eli Y. Adashi, Minoru Fukuda
Journal: Journal of Clinical Investigation (2002)

The endocrine symphony known as the reproductive life cycle consists of a complex series of hormonally driven “movements.” The sole rationale for the reproductive cycle is the generation of a fertilizable ovum and, contingent upon fertilization, the establishment of implantation and of an ongoing gestation. Although fecundity rates vary among species, there can be little question as to the ongoing success of sexual reproduction.
Australia faces huge rebuild after devastating floods
Authors: M. Sweet
Journal: BMJ (2011)

Australia faces a huge reconstruction effort in the wake of ongoing flooding that is devastating vast swathes of the country and is expected to have a long term effect on the population’s health.

Queensland, “the sunshine state” in the country’s north east, has been hardest hit by the past week’s flash floods, although most states have been affected over the past month, and more heavy rains are forecast.

Three quarters of Queensland has been declared a disaster zone, and the floods there have killed at least 20 people, affected 28 000 homes, and shut down the capital city of Brisbane. Meanwhile the state of Victoria is facing severe flooding, with predictions that 70 towns will be struck this week. Although hospitals have generally managed to continue operations during the crisis, the Royal Australian College of General Practitioners estimates that at least 1000 of …
Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials: A Position Statement of the American Diabetes Association and a Scientific Statement of the American College of Cardiology Foundation and the American Heart Association
Authors: Søren S. Lund, Allan A. Vaag
Journal: Diabetes Care (2009)

Recently, international cardiovascular disease (CVD) and diabetes associations have published type 2 diabetes treatment guidelines based on the UK Prospective Diabtes Study (UKPDS), the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, the Action in Diabetes and Vascular Disease—Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial, and the Veterans Affairs Diabetes Trial (VADT) (1,2), among others, recommending an A1C target of <7.0% for most patients. The evidence supporting this recommendation is ranked as level A—the highest possible (with evidence from multiple randomized trials/meta-analyses) (1). However, to our knowledge, the Kumamoto study of 110 Japanese patients is the only long-term type 2 diabetes investigation of intensive versus conventional control with clinical events as primary outcomes that has adopted this recommendation (3).

The UKPDS, ACCORD, ADVANCE, and VADT (or …
On Complete Removal of the Prostate
Authors: H. S. Souttar
Journal: BMJ (1947)

It will be generally agreed that the extravesical approach to the prostate introduced by Millan presents considerable advantages over the older transvesical methods.It enables one to observe every step of the operation in a way which was formerly impossible, bleeding is readily controlled, and the post-operative period is short and easy.Some recent experiences have, however, suggested to me that the operation for prostatic obstruction performed by this route is still capable of substantial development, and although some considerable time must elapse before this can be established it seemed worth while to place these experiences on record.
Viral Infection in Patients with Severe Pneumonia Requiring Intensive Care Unit Admission
Authors: Sang-Ho Choi, Sang-Bum Hong, Gwang-Beom Ko, Yumi Lee, Hyun Jung Park, So-Youn Park, Song Mi Moon, Oh-Hyun Cho, Ki-Ho Park, Yong Pil Chong, Sung-Han Kim, Jin Won Huh, Heungsup Sung, Kyung-Hyun Do, Sang-Oh Lee, Mi-Na Kim, Jin-Yong Jeong, Chae-Man Lim, Yang Soo Kim, Jun Hee Woo, Younsuck Koh
Journal: American Journal of Respiratory and Critical Care Medicine (2012)

Rationale: The role of viruses in pneumonia in adults and the impact of viral infection on mortality have not been elucidated. Previous studies have significant limitations in that they relied predominantly on upper respiratory specimens.Objectives: To investigate the role of viral infection in adult patients with pneumonia requiring intensive care unit (ICU) admission.Methods: A retrospective analysis of a prospective cohort was conducted in a 28-bed medical ICU. Patients with severe community-acquired pneumonia (CAP) or healthcare-associated pneumonia (HCAP) were included in the study.Measurements and Main Results: A total of 198 patients (64 with CAP, 134 with HCAP) were included for analysis. Of these, 115 patients (58.1%) underwent bronchoscopic bronchoalveolar lavage (BAL), 104 of whom were tested for respiratory viruses by BAL fluid reverse-transcription polymerase chain reaction (RT-PCR). Nasopharyngeal specimen RT-PCR was performed in 159 patients (84.1%). Seventy-one patients (35.9%) had a bacterial infection, and 72 patients (36.4%) had a viral infection. Rhinovirus was the most common identified virus (23.6%), followed by parainfluenza virus (20.8%), human metapneumovirus (18.1%), influenza virus (16.7%), and respiratory syncytial virus (13.9%). Respiratory syncytial virus was significantly more common in the CAP group (CAP, 10.9%; HCAP, 2.2%; P = 0.01). The mortalities of patients with bacterial infections, viral infections, and bacterial-viral coinfections were not significantly different (25.5, 26.5, and 33.3%, respectively; P = 0.82).Conclusions: Viruses are frequently found in the airway of patients with pneumonia requiring ICU admission and may cause severe forms of pneumonia. Patients with viral infection and bacterial infection had comparable mortality rates.
Probing Informed Consent in Schizophrenia Research
Authors: Joan Stephenson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Keeping in touch: A paper reunion
Authors: H. Sapper
Journal: BMJ (1997)

Medical school is a working life time away as retirement approaches. Contact with contemporaries may be tenuous and memories hazy. I went to my year's 40th reunion out of curiosity. Most there were instantly recognisable by voice, mannerism, and surprisingly by appearance too. The conversations were of illness, bereavement, and death. Surely something good must be happening to someone?

Finding out required an accurate list of names and addresses. No group's progress through medical school is tidy—1st MB exemptions, intervening BScs, illness, and examination failure disrupt it. Class lists do not tell the whole story of who did what when. The medical school's old student directory is not updated annually.

Cross referencing the school's list with the …
Alteration in sexually dimorphic testosterone biotransformation profiles as a biomarker of chemically induced androgen disruption in mice.
Authors: V S Wilson, J B McLachlan, J G Falls, G A LeBlanc
Journal: Environmental Health Perspectives (1999)

Assessment of the impact of environmental chemicals on androgen homeostasis in rodent models is confounded by high intraindividual and interindividual variability in circulating testosterone levels. Our goal was to evaluate changes in testosterone biotransformation processes as a measure of androgen homeostasis and as a biomarker of exposure to androgen-disrupting chemicals. Sex-specific differences in hepatic testosterone biotransformation enzyme activities were identified in CD-1 mice. Gonadectomy followed by replacement of individual steroid hormones identified specific sex differences in biotransformation profiles that were due to the inductive or suppressive effects of testosterone. Notably, significant androgen-dependent differences in testosterone 6[alpha]- and 15[alpha]-hydroxylase activities were demonstrated, and the ratio of 6[alpha]- and 15[alpha]-hydroxylase activities proved to be an excellent indicator of the androgen status within the animal. The male or
Complexing of Acid Mucopolysaccharides and Serum Beta-Lipoproteins.
Authors: A. Lopez-S.
Journal: Annals of Internal Medicine (1969)

s1 May 1969Complexing of Acid Mucopolysaccharides and Serum Beta-Lipoproteins.A. Lopez-S., M.D., Ph.D., S. R. Srinivasan, Ph.D., B. Radhakrishnamurthy, Ph.D., G. S. Berenson, M.D., F.A.C.P.A. Lopez-S., M.D., Ph.D.Search for more papers by this author, S. R. Srinivasan, Ph.D.Search for more papers by this author, B. Radhakrishnamurthy, Ph.D.Search for more papers by this author, G. S. Berenson, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1102_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe ability of serum low-density lipoproteins to form complexes with different polyanions has been previously described, but the mechanisms by which these complexes are formed remains obscure. The potential of lipoproteins to complex with acid mucopolysaccharides in vascular intima is important to the pathogenesis of atherosclerosis. The in vitro conditions for optimum formation of complexes have been studied. Chromatographic (column) and electrophoretic (paper, gel, and immunoelectrophoresis) evidence indicates the formation of complexes between beta lipoproteins with mucopolysaccharides. Calcium, phospholipids of beta lipoproteins, and certain reactive groups of mucopolysaccharides seem to be essential for complexing. Using different levels of calcium and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. Lopez-S., M.D., Ph.D.; S. R. Srinivasan, Ph.D.; B. Radhakrishnamurthy, Ph.D.; G. S. Berenson, M.D., F.A.C.P.Affiliations: New Orleans, Louisiana PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1102-1102KeywordsAtherosclerosisCalciumImmunoelectrophoresisLipoproteinsLow density lipoproteinPathogenesisPhospholipids ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Primary osteoblast-like cells from patients with end-stage kidney disease reflect gene expression, proliferation, and mineralization characteristics ex vivo
Authors: Renata C. Pereira, Anne M. Delany, Nadine M. Khouzam, Richard E. Bowen, Earl G. Freymiller, Isidro B. Salusky, Katherine Wesseling-Perry
Journal: Kidney International (2014)
Studying Complementary and Alternative Therapies
Authors: Paul A. Offit
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis
Authors: I Tchetverikov
Journal: Annals of the Rheumatic Diseases (2003)

To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix metalloproteinase (MMP) activity in alpha(2) macroglobulin (alpha(2)M)/MMP complexes and the progression of joint destruction in patients with recent onset rheumatoid arthritis (RA).109 patients with RA of recent onset were entered into this longitudinal study. Patients were followed up for two years; clinical data, blood samples, and radiographs were obtained at baseline and at 1 and 2 years. Serum levels of MMPs were measured by sandwich ELISA and MMP activity assays.During the two years joint damage progressed from 0 to 10 (median Sharp score, p<0.001). Stable levels of pro-MMP-3 and a significant decrease in the levels of pro-MMP-8 and -9 and alpha(2)M/MMP complexes were seen throughout the two years. Regression analysis showed that serum pro-MMP-3 levels at disease onset were independently associated with the progression of joint damage (B=0.7, 95% CI 0.3 to 1.1, p=0.001). Based on the rate of joint destruction, patients were divided into two subgroups: patients with mild and severe joint damage progression. The pro-MMP-3 levels were significantly higher in the group with severe compared with mild disease at all times. Levels of pro-MMP-8 and -9 were decreased in both groups, whereas alpha(2)M/MMP complex levels decreased in the group with mild disease only.Serum levels of the MMPs studied are associated with disease activity, but serum pro-MMP-3 levels at the onset of disease are also predictive of joint damage progression.
Zonation of cholesterol and glycerolipid synthesis in regenerating rat livers
Authors: Hui-Cheng Cheng, Chuen-May Yang, Ming-Shi Shiao
Journal: Hepatology (1993)

Hepatic zonation of cholesterol and glycerolipid synthesis was investigated in regenerating rat livers 24 hr after partial hepatectomy. Tritiated acetate and [U-14C]glycerol were injected into rats' peritoneal cavities for a short-term labeling study. Periportal and perivenous hepatocytes were isolated by digitonin collagenase perfusion. Cholesterol synthesis was significantly higher in periportal hepatocytes of the sham-operated livers (periportal/perivenous = 1.67; p < 0.05). Twenty-four hours after partial hepatectomy, cholesterol synthesis was selectively decreased by 40% (p < 0.01) in periportal hepatocytes. Consequently, hepatic zonation of cholesterol synthesis was abolished in regenerating livers. To study the cholesterol homeostasis on a long-term basis, we substituted deuterated water (25% enriched) for drinking water for 5 days to label newly synthesized cholesterol in a steady state. This procedure clearly demonstrated the net negative cholesterol balance 24 hr after partial hepatectomy. However, the newly synthesized cholesterol contributed equally to the cellular cholesterol pool in both zones. The synthesis of glycerolipids, whether measured from tritiated acetate or [U-14C]glycerol, was significantly increased without apparent zonation in the regenerating livers (twofold increase in phospholipid, and threefold to sevenfold increase in triacylglycerol). We concluded that hepatic zonation of cholesterol synthesis is caused by higher de novo synthesis in periportal hepatocytes, which is abolished in regenerating livers. No zonation of glycerolipid synthesis exists in normal and regenerating livers.
Availability of computed tomography
Authors: S J Golding, A J Molyneux
Journal: BMJ (1989)

hydrate depletion on insulin requirements are therefore small and would be offset by the in- creased fat intake seen during lactation.Thus the increased insulin sensitivity associated with lactation seems to arise despite the prevailing metabolic conditions.Further, evidence from other species suggests that this has a specific physiological role in maintaining successful lacta- tion.'The lower circulating insulin concentration seen during normal lactation leads to a reduction in lipoprotein uptake and increased mobilisation of lipid stores from peripheral adipose tissue.In contrast, the lactating mammary gland shows an increase in insulin receptors and hence an increase in lipoprotein uptake and utilisation.4The net result of these processes is an increased availability of lipid substrates for use by the lactating mammary gland.In addition to these effects, the lower insulin concentrations may have a role in reducing non-lactational energy expenditure seen in women breast feeding.2The increase in insulin sensitivity observed during lactation, which is reversible on weaning, thus seems to be a physiological adaptation of vital importance for maintaining milk production.