Prevention of Hepatitis with Gamma Globulin
Authors: MARCEL E. CONRAD
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 June 1980Prevention of Hepatitis with Gamma GlobulinMARCEL E. CONRAD, M.D.MARCEL E. CONRAD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-6-868 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the December issue, Hoofnagle and colleagues (1) conclude that immune serum gamma globulin (ISG) preparations produce passive-active immunity when administered after exposure and suggest that when older lots of ISG were administered before exposure, they acted by inducing active immunity. Further they speculate that with the introduction of hepatitis B surface antigen (HBsAg) screening of donors in 1972, the immunogenic effect of serum globulin probably disappeared for hepatitis B. Their data and that of others provide reasonable support for the conclusion that after exposure, ISG administration acts by passive-active immunization. Their other conclusions, however, deserve closer...References1. HOOFNAGLESEEFFBALESWRIGHTZIMMERMAN JLZEH. Passive-active immunity from hepatitis B immune globulin: reanalysis of a Veterans Administration Cooperative Study of needle-stick hepatitis. Ann Intern Med. 1979;91:813-8. LinkGoogle Scholar2. . Prophylactic gamma globulin for prevention of endemic hepatitis: effects of US gamma globulin upon the incidence of viral hepatitis and other infectious diseases in US soldiers abroad. Arch Intern Med. 1971;128:723-38. CrossrefMedlineGoogle Scholar3. GINSBERGCONRADBANCROFTLINGOVERBY AMWCL. Prevention of endemic HAA-positive hepatitis with gamma globulin: use of a simple radioimmune assay to detect HAA. N Engl J Med. 172;286:562-6. CrossrefMedlineGoogle Scholar4. SZMUNESSPRINCEGOODMANEHRLICHPICKANSARI WAMCRM. Hepatitis B immune serum globulin in prevention of nonparenterally transmitted hepatitis B. N Engl J Med. 1974;290:701-6. CrossrefMedlineGoogle Scholar5. KNODELLCONRADGINSBERGBELLFLANNERY RMACE. Efficacy of prophylactic gamma-globulin in preventing non-A, non-B post-transfusion hepatitis. Lancet. 1976;1:557-61. CrossrefMedlineGoogle Scholar1. HOOFNAGLESEEFFBALESWRIGHTZIMMERMAN JLZEH. Passive-actice immunity from hepatitis B immune globulin: reanalysis of a Veterans Administration Cooperative Study of needle-stick hepatitis. Ann Intern Med. 1979; 91:813-8. LinkGoogle Scholar2. MOSLEY J. Hepatitis B immune globulin: some progress and some problems. Ann Intern Med. 1979; 91:914-6. LinkGoogle Scholar3. . Prophylactic gamma globulin for prevention of endemic hepatitis: effects of US gamma globulin upon the incidence of viral hepatitis and other infectious diseases in US soldiers abroad. Arch Intern Med. 1971; 128:723-38. CrossrefMedlineGoogle Scholar4. GINSBERGCONRADBANCROFTLINGOVERBY AMWCL. Prevention of endemic HAA-positive hepatitis with gamma globulin: use of a simple radioimmune assay to detect HAA. N Engl J Med. 1972;286:562-6. CrossrefMedlineGoogle Scholar5. GINSBERGCONRADBANCROFTLINGOVERBY AMWCL. Antibody to Australia antigen: detection with a simple radioimmune assay, incidence in military populations, and role in the prevention of hepatitis B with gamma globulin. J Lab Clin Med. 1973;82:317-25. MedlineGoogle Scholar1. . Prophylactic gamma globulin for prevention of endemic hepatitis. Arch Intern Med. 1971;128:723-38. CrossrefMedlineGoogle Scholar2. KRUGMANWARDGILESJACOBS SRJA. Infectious hepatitis: studies on the effect of gamma globulin and on the incidence of inapparent infection. JAMA. 1960;174:823-30. CrossrefMedlineGoogle Scholar3. GERETYTABORPURCELLTYERYAR RERF. Summary of an international workshop on hepatitis B vaccines. J Infect Dis. 1979;140:642-8. CrossrefMedlineGoogle Scholar4. HOOFNAGLESEEFFBALESZIMMERMAN JLZH. Type B hepatitis after transfusion with blood containing antibody to hepatitis B core antigen. N Engl J Med. 1978;298:1379-83. CrossrefMedlineGoogle Scholar5. HOOFNAGLEWAGGONER JJ. Hepatitis A and B virus markers in immune serum globulin. Gastroenterology. 1980;78:259-63. CrossrefMedlineGoogle Scholar6. SEEFFHOOFNAGLE LJ; Immunoprophylaxis of viral hepatitis. Gastroenterology. 1979;77:161-82. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Alabama Birmingham, AL 35294 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1980Volume 92, Issue 6Page: 868-871KeywordsGlobulinsHepatitisHepatitis BHepatitis B surface antigenImmune serumImmune serum globulinImmunity Issue Published: 1 June 1980 PDF downloadLoading ...