tbuckley/cabot-search huggingface dataset:
Proposal for a Synthetic Lethality Therapy Using the Paralog Dependence of Cancer Cells—Response
Authors: Takahiro Oike, Hideaki Ogiwara, Takashi Nakano, Takashi Kohno
Journal: Cancer Research (2014)

We thank Dr. Thompson and colleagues for their insightful comments about our article ([1][1]). We have now reevaluated our finding based on their comments.

Recently, two studies sought to identify synthetic lethal partners for BRG1 using the same (and other) cancer cell lines as used by us ([2, 3][
Biomedical and Psychiatric Risk Factors for Retinopathy Among Children With IDDM
Authors: Maria Kovacs, Protap Mukerji, Allan Drash, Satish Iyengar
Journal: Diabetes Care (1995)

OBJECTIVE Illness duration and glycemic control influence the development of retinopathy in childhood-onset insulin-dependent diabetes mellitus (IDDM). Psychiatric disorders and sociodemographic factors also affect diabetes-related outcomes. However, biomedical and psychosocial factors have not been examined together in modeling the risk of retinopathy. RESEARCH DESIGN AND METHODS We conducted a single-site prospective longitudinal study of 66 children (aged 8-13 years) newly diagnosed with IDDM. Repeated assessments served to derive psychiatric diagnoses. Poor glycemic control was defined as the upper 15th percentile of all HbA1 values. After a median follow-up of 10 years, severity of retinopathy was determined. It was modeled with a stepwise polychotomous regression procedure using antecedent biomedical and psychosocial variables. RESULTS Young adults with childhood-onset IDDM were found to be at increased risk of retinopathy the longer they had IDDM, the more persistently they evidenced poor antecedent glycemic control, and the longer they suffered from depressive illness. These three factors operated individually and additively, with duration of IDDM conferring a baseline level of risk. In depressed patients (27%), depression onset antedated the detection of retinopathy generally by 7 years. CONCLUSIONS Duration of childhood-onset IDDM confers a baseline level of risk of retinopathy irrespective of glycemic control; antecedent clinical depression is also a risk factor. Depression therefore may serve as a marker of vulnerability and help to identify a subgroup of patients at risk for complications. The findings raise the question whether timely treatment of depression could forestall diabetic retinopathy.
Common nonsynonymous variants in PCSK1 confer risk of obesity
Authors: Michael Benzinou, John W M Creemers, Helene Choquet, Stephane Lobbens, Christian Dina, Emmanuelle Durand, Audrey Guerardel, Philippe Boutin, Beatrice Jouret, Barbara Heude, Beverley Balkau, Jean Tichet, Michel Marre, Natascha Potoczna, Fritz Horber, Catherine Le Stunff, Sebastien Czernichow, Annelli Sandbaek, Torsten Lauritzen, Knut Borch-Johnsen, Gitte Andersen, Wieland Kiess, Antje Körner, Peter Kovacs, Peter Jacobson, Lena M S Carlsson, Andrew J Walley, Torben Jørgensen, Torben Hansen, Oluf Pedersen, David Meyre, Philippe Froguel
Journal: Nature Genetics (2008)
NEW ANTITUBERCULOSIS DRUGS
Authors: Floyd M. Feldmann
Journal: JAMA (1952)

To the Editor:—  The editorial entitled New Antituberculosis Drugs, which appeared in the March 22 issue ofThe Journal, was an excellent summary of the information now available; however, more could have been said concerning the caution necessary in the evaluation of these drugs. I should like to call attention to the last four paragraphs of a statement recently prepared by the American Trudeau Society, the medical section of the National Tuberculosis Association:  At present there is no reason to believe that the fundamentals of therapy of tuberculosis should be altered in any way when isonicotinic acid hydrazide is employed. Patients receiving the drug should be hospitalized for careful observation. They should be studied in institutions where potential toxic manifestations may be watched for most carefully and where effects upon the course of the underlying tuberculosis may be carefully observed so that suitable alterations of therapy may be initiated when
Surgery for intracranial tumours.
Authors: C. De Voil, S. N. Sinha
Journal: BMJ (1968)

themselves to logical interpretation.Rather they perpetuate the need for empirical rules in interpretation.The electrocardiogram is recorded in two planes, the frontal and transverse.The frontal plane includes the six limb leads.There is disagreement about precise reference of these leads to the heart.Earlier hexaxial reference systems were based on an absolute acceptance of Einthoven's theories.It is now thought that these theories may not be accu- rate, and a corrected reference system has been introduced.! Whatever the theoretical considerations, in practice these six limb leads may be represented as viewing the heart from a series of approximate positions in the frontal plane.Uhley and Rosenblum' consider that it would be logical to display the limb leads in the order aVR, aVL, I, II, aVF, III.The chest leads describe an arc in the transverse plane.The two planes coincide in the area of V6, so that V. could also be included with the frontal plane leads.V. is usually intermediate in pattern between leads I and II, as would be expected from their points of reference.Thus the two planes may be combined in displaying the electro- cardiogram (see Fig.).When mounted in this way there is a gradual change of pattern from aVR, through aVL,, I, V6, II, aVF, to III, and similarly from VI-6.The electrical axis can be read at a glance.Ischaemic changes will be grouped together, so that, for example, a lateral infarction would give rise to abnormal tracings in leads mounted along the right-hand side of the paper.This presentation may simplify interpreta-
Effect of the 1983 Mental Health Act on the management of psychiatric patients.
Authors: L Webster, C Dean, N Kessel
Journal: BMJ (1987)

Two principal objectives of the 1983 Mental Health Act were to decrease the use of emergency orders and to give patients on observation orders the right of appeal. Statistics were collected from the 13 hospitals that admit acute psychiatric patients in the Greater Manchester area, and the figures for 1980-1 were compared with those for 1984-5. Changes in use of the different sections were examined in university units, large psychiatric hospitals, and district general hospital units. The use of emergency orders decreased and the use of treatment orders increased; the use of observation orders remained unchanged. Many more patients exercised their right of appeal in 1984-5, but the number discharged by tribunals remained small. The nurses9 holding power was used infrequently. The different types of hospital are now more concordant in their use of these orders than before the 1983 act.
The First Wake
Authors: Lydia Y Kang
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Care of children in general practice.
Authors: E M Davis
Journal: BMJ (1979)

The frequency of subclinical infection is at this stage difficult to project.Testing of "normal" sera with a rather arbitrary haemagglutinating antigen2 may unearth anti- body but, if there can be antigen sharing among Gram-negative organisms its specificity may also be in doubt.In the end there has to be some relation to the clinical disease.Another survey3 of over 2000 persons from various population groups in the Nottingham area, which has experienced the disease, showed antibody as measured by specific fluorescence in only 31 (15 °O) Rapid identification of legionella from patient material is very necessary.Bacteriological methods of culture have been described' and further selective media are under study.
Hemoglobinopathic Erythrocytosis due to a New Electrophoretically Silent Variant, Hemoglobin San Diego (β109(G11)Val→Met)
Authors: Peter E. Nute, George Stamatoyannopoulos, Mark A. Hermodson, Daniel Roth
Journal: Journal of Clinical Investigation (1974)

Examination of 13 members of a Filipino family revealed that 6 had erythrocytosis inherited as a simple autosomal dominant trait. Application of several electrophoretic and chromatographic tests failed to reveal the presence of an abnormal hemoglobin in hemolysates from affected individuals. However, measurements of oxygen dissociation curves using whole bloods, dialyzed hemolysates, and 2,3-diphosphoglyceric acid-stripped hemolysates clearly showed that affected persons had an abnormal hemoglobin characterized by a high affinity for oxygen. Compositional analyses of all tryptic peptides from the beta-chains of the proband revealed a valyl-methionyl ambiguity in betaT12a. Blockage of lysyl residues and subsequent tryptic hydrolysis at arginyl residues permitted the isolation of fragments containing residues 105 through 146. Automatic sequence analysis of the fragments demonstrated the presence of both valine and methionine in nearly equal proportions at position beta109. This new hemoglobin variant is designated Hb San Diego (beta109(G11) Val-->Met).
Progression to Overt Nephropathy in Type 2 Diabetes
Authors: Graziella Bruno, Franco Merletti, Annibale Biggeri, Giuseppe Bargero, Stefania Ferrero, Gianfranco Pagano, Paolo Cavallo Perin
Journal: Diabetes Care (2003)

The first sign of diabetic nephropathy is microalbuminuria, but its predictive role of progression to overt nephropathy in type 2 diabetes has not yet been clarified. The aims of this study were to assess during 7 years of follow-up the incidence rate of overt nephropathy and the predictive role of microalbuminuria and other baseline variables (blood pressure, lipids, fibrinogen, uric acid, smoking, and HbA(1c) cumulative average during follow-up).A prospective population-based study was performed in Casale Monferrato, Italy, including 1,253 type 2 diabetic patients recruited at baseline (1991-1992), 765 with normoalbuminuria (albumin excretion rate [AER] <20 microg/min) and 488 with microalbuminuria (AER 20-200 microg/min). All measurements were centralized. A nested case-control study within the cohort was performed, selecting four control subjects, frequency matched for age and attained individual time of follow-up with each case. Conditional regression analysis was performed to assess variables independently associated with risk of progression to overt nephropathy.Of 1,253 total patients, 1,103 (88.0%) were included in the follow-up examination (median 5.33 years); their age and duration of disease at baseline were 68.4 +/- 10.5 years and 10.4 +/- 6.6 years, respectively. Cases of overt nephropathy were 202, giving an incidence rate of 37.0/1,000 person-years (95% CI 32.3-42.6). In conditional logistic regression analyses, microalbuminuria provided a 42% increased risk with respect to normoalbuminuria (95% CI 0.98-2.06), independently of duration of diabetes, hypertension, and systolic blood pressure. Other variables independently associated with progression to overt nephropathy were HbA(1c) cumulative average (P = 0.002), apolipoprotein B (P = 0.013), fibrinogen (P = 0.02), and HDL cholesterol (P = 0.03).Of type 2 diabetic patients, 3.7% progress every year to overt nephropathy. Microalbuminuria is associated with a 42% increased risk of progression to overt nephropathy. Other independent predictors are HbA(1c), HDL cholesterol, apolipoprotein B, and fibrinogen.
UK government is to reconsider claims of children who developed narcolepsy after vaccination
Authors: C. Dyer
Journal: BMJ (2013)

The UK government has told parents whose children developed narcolepsy after receiving the swine flu vaccine that it will reconsider their compensation claims, after previously rejecting them on the ground that no causal link had been proved.

The move follows a study commissioned by the Health Protection Agency, which indicated that one in around 55 000 children aged between 4 years …
PULMONARY TUBERCULOSIS IN CHILDHOOD
Authors: G. B. Dixon
Journal: BMJ (1931)

long-standing ulcerative colitis.The mucous membrane of the rectum was normal, the blood having come fronm haemorrhoids, and the lumen was filled with effervescing fluid faeces, which indicated that the diarrhoea was due -to carbohydrate intestinal dyspepsia.Rapid recovery followed abstention from starch-containing vegetables. X-RAY INVESTIGATIONThe x rays are very useful in investigating cases of ulcerative colitis.As the normal haustration of the bowel disappears in the affected part, it is possible, by means *of a barium enema, to determine the extent of the disease.It is not uncommon for more or less of the proximal part to be spared in cases in which the pelvic colon and rectum are severely involved.When recovery * Summary of an address read to the infant welfare subgroup of the Midland branch of the Society of Medical Officers of Health.
CATARACT. HOW SHALL WE DEAL WITH THE CAPSULE? NEW CYSTITOME FORCEPS.
Authors: EUGENE SMITH
Journal: JAMA (1891)

Local anæthesia. (cocaine) and antisepsis have been the means of producing a great revolution in the operation of cataract. Eserine, also, plays a somewhat important part. The Graefe modified linear extraction—linear incision combined with iridectomy—which has been so generally adopted as<i>the</i>operation for cataract, because of its supposed avoidance of iritis and consecutive destruction of the cornea, easier and better healing of the wound, etc., has, with the majority of the leading ophthalmic surgeons of the present day, been supplanted by simple extraction with a small flap (one-third of the cornea, De Wecker), and<i>without</i>iridectomy, a near return to the old classical operation, and the success of the opera tion is as great or greater than the Graefe method, and is in no small measure due to the use of cocaine, and the removal of all kinds of infectious factors which may exist in the conjunctival sac, lachrymal
The monocyte‐derived chemokine is released in the bronchoalveolar lavage fluid of steady‐state asthmatics
Authors: D. Lezcano‐Meza, M. C. Negrete‐Garcia, M. Dante‐Escobedo, L. M. Teran
Journal: Allergy (2003)

Infiltration of the airways by T helper type 2 (Th2) lymphocytes is a well‐recognized feature of bronchial asthma. Monocyte‐derived chemokine (MDC) is a potent attractant which activates Th2 lymphocytes via the chemokine receptor CCR4. We have investigated both leukocyte recruitment and MDC release into the airways of asthmatic patients. Differential cell counts in bronchoalveolar lavage (BAL) fluid showed that numbers of lymphocytes and eosinophils were elevated in asthmatics compared with normal subjects (median, 6.1 vs. 1.0 × 10 3 /ml, P &lt; 0.005 and 1.4 vs. 0.24 × 10 3 /ml, P = 0.001, respectively). By enzyme‐linked immunosorbent assay it was demonstrated that MDC concentrations were significantly elevated in BAL fluid from asthmatics compared with normals (medians 282 pg/ml, range 190–780 pg/ml vs. median 29 pg/ml range 17–82 pg/ml, P &lt; 0.001). Interestingly, there was a significant correlation between MDC levels and the bronchoconstrictive response to methacholine [PC 20 forced expiratory volume (FEV) 1 , r = −0.78, P = 0.001], suggesting that MDC may be involved in the severity of the disease. By immunohistochemistry, MDC was localized predominantly to the bronchial epithelium in bronchial biopsies derived from stable asthmatics. Moreover, primary human airway epithelial cells were found to release MDC upon cytokine stimulation. These findings suggest that MDC may play a major role in the pathogenesis of bronchial asthma.
Storage mite allergy among grain elevator workers
Authors: P. Revsbech, G. Andersen
Journal: Allergy (1987)

A total of 139 workers (71% of the available work force) in four grain elevator stores in Aalborg, Denmark, participated in a cross-sectional study on the prevalence of storage mite allergy among grain elevator workers. All underwent interview, prick test with a standard panel of allergens and the storage mites Acarus siro, Lepidoglyphus destructor and Tyrophagus putrescentiae, RAST to the three above-mentioned storage mites plus Glycyphagus domesticus and wheat, measurement of serum total IgE, and spirometry. Pulmonary symptoms were present among 44%, nasal and eye symptoms among 48%. Thirty-one per cent complained of work-related respiratory symptoms. Fourteen per cent of these workers had only nasal symptoms. Comparing the prick test result and the history, 6.4% had respiratory storage mite allergy, while 15.9% were sensitized to storage mites. Storage mites seem to be the most important allergen among grain elevator workers in Denmark. Faunistic examination of samples of grain and dust showed that storage mites, in particular A. siro, L. destructor and T. longior, were found in 73% of grain samples, while all dust samples contained mites.
Unexplained Technetium-99m DTPA Uptake by Lung
Authors: FIONA M. A. WILSON, FRANCIS W. SMITH
Journal: Clinical Nuclear Medicine (1987)

Bilateral basal lung uptake of Tc-99m DTPA was observed on late renogram images of a man with a known history of ischemic heart disease. The patient was being investigated for hypertension. A chest radiograph at that time showed cardiomegaly and pulmonary edema. Lung uptake of Tc-99m DTPA has not been described previously, and it is presumed that in this case it is due to pulmonary edema with no pleural effusions.
Bacterial Cultures for Cystitis
Authors: James R. Johnson, Walter E. Stamm
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 June 1990Bacterial Cultures for CystitisJames R. Johnson, MD, Walter E. Stamm, MDJames R. Johnson, MDSearch for more papers by this author, Walter E. Stamm, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-12-966_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In his recent letter (1), Dr. Washington sees as contradictory our proposing both that clinical laboratories should detect and report bacteriuria down to a level of 103colony forming units (cfu) per mL and that urine cultures should be omitted in many cases of uncomplicated acute cystitis (2). Our recommendation to omit pretherapy urine cultures applies only to women with suspected acute cystitis who have no known complicating factors, whose clinical presentation is straightforward, and in whom the urinalysis supports the diagnosis of a bacterial urinary tract infection. When a urinary tract infection is suspected in other...References1. Washington J. Bacterial cultures for cystitis [Letter]. Ann Intern Med. 1990;112:387-8. LinkGoogle Scholar2. JohnsonStamm JW. Urinary tract infections in women: diagnosis and treatment. Ann Intern Med. 1989;111:906-17. LinkGoogle Scholar3. StammCountsRunning WGK. Diagnosis of coliform infection in acutely dysuric women. N Engl J Med. 1982;307:463-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1990Volume 112, Issue 12Page: 966-966KeywordsBacterial culturesClinical laboratoriesColony forming unitsCystitisUrinary tract infectionsUrine Issue Published: 15 June 1990 PDF DownloadLoading ...
Abstract 2596: Inhibition of PI3K-mTOR pathway using combination of chloroquine and aspirin regimen leads to apoptosis in pancreatic cancer cells.
Authors: Arvind Thakkar, B. Karthik Grandhi, Jeffrey Wang, Sunil Prabhu
Journal: Cancer Research (2013)

Abstract Pancreatic cancer ranks as the fourth most deadly form of cancer in the United States with approximately 37,000 deaths each year. The present study aims to evaluate the combinatorial chemopreventive effects of low doses of chloroquine (CQ) and aspirin (ASP) alone and in combination CQA (CQ+ASP) on three pancreatic cancer cell lines, MIA PaCa-2, Panc-1 and BxPC-3. Results demonstrated that low doses of CQ (6.25μM) and ASP (1mM) alone did not reduce cell viability, whereas combination CQA reduced cell viability by ∼80% (P&amp;lt;0.001). CQA combination blocked cell cycle progression at G0/G1 checkpoint. The CQA treatment for 24 h inhibited the NF-κB p50 DNA binding activity by ∼45% (P&amp;lt;0.01) in MIA PaCa-2 and BxPC-3 cells, but no NF-κB inhibition observed in Panc-1 cells. Mechanistic studies revealed that treatment with CQA combination increased the expression of LC3-II protein, indicates inhibition of autophagy. In order to verify the involvement of PI3K and mTOR pathway in CQA-induced apoptosis, we used PI3K inhibitor (3-MA) and mTOR inhibitor (Rapamycin) and analyzed by cell viability assay. The inhibition of PI3K by 3-MA pretreatment enhanced the cell growth inhibition of CQA treatment, whereas the inhibition of m-TOR by rapamycin pretreatment attenuated CQA induced reduction in cell viability. Overall, our results for the first time, illustrate that low dose CQA combinations impart synergistic suppressive activity than chemopreventive agents alone, thus confirming the importance of novel combination chemoprevention strategies against pancreatic cancer. Citation Format: Arvind Thakkar, B. Karthik Grandhi, Jeffrey Wang, Sunil Prabhu. Inhibition of PI3K-mTOR pathway using combination of chloroquine and aspirin regimen leads to apoptosis in pancreatic cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2596. doi:10.1158/1538-7445.AM2013-2596