THE EPIDEMIOLOGY OF ACUTE RESPIRATORY INFECTIONS CONDITIONED BY SULFONAMIDES.
Authors: L. A. JULIANELLE
Journal: Annals of Internal Medicine (1945)

Article1 January 1945THE EPIDEMIOLOGY OF ACUTE RESPIRATORY INFECTIONS CONDITIONED BY SULFONAMIDES.IV. TRENDS IN PNEUMOCOCCAL TYPES INITIATED BY DRUG TREATMENT*L. A. JULIANELLE, MORRIS SIEGELL. A. JULIANELLESearch for more papers by this author, MORRIS SIEGELSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-1-29 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn an earlier communication,1the occasion was taken to comment on the observation that judged by superficial examination, the continual use of sulfadiazine exerted little effect on the frequency of pneumococcus in the throat cultures of physically normal children. It was intimated, however, that underneath the surface this organism was actually participating in a profound process reminiscent of natural selection. It is proposed to submit in the present report a detailed account of the alterations observed and to describe the correlated experiments undertaken to explain their occurrence. The general method employed in handling the children, half under sulfadiazine treatment and...Bibliography1. JULIANELLESIEGEL LAM: The epidemiology of acute respiratory infections conditioned by sulfonamides: II. Gross alterations in the nasopharyngeal flora associated with treatment, Ann. Int. Med., 1945, xxii, 10-20. LinkGoogle Scholar2. SIEGELJULIANELLE MLA: The epidemiology of acute respiratory infections conditioned by sulfonamides: I. General clinical considerations, Ann. Int. Med., 1945, xxii, 1-9. LinkGoogle Scholar3. SIEGELMUCKENFUSS MRS: A study in active immunization against epidemic influenza and pneumococcus pneumonia at Letchworth Village: II. Results of active immunization against pneumonia with pneumococcal polysaccharide, Am. Jr. Hyg., 1941, xxxiv, 70-109. Google Scholar4. FINDLAND M: Recent advances in the epidemiology of pneumococcal infections, Medicine, 1942, xxi, 307-344. CrossrefGoogle Scholar5. LOWELLSTRAUSSFINLAND FCEM: Observations on the susceptibility of pneumococci to sulfapyridine, sulfathiazole and sulfamethylthiazole, Ann. Int. Med., 1940, xiv, 1001-1023. Google Scholar6. HAMBURGERSCHMIDTRUEGSEGGERSESLERGRUPEN MLHJMCLES: Sulfonamide resistance developing during treatment of pneumococcic endocarditis, Jr. Am. Med. Assoc., 1942, cxix, 409-411. CrossrefGoogle Scholar7. FRISCHPRICEMYERS AWAEGB: Type VIII Pneumococcus: development of sulfadiazine resistance, transmission by cross infection, and persistence in carriers, Ann. Int. Med., 1943, xviii, 271-278. Google Scholar8. HAMBURGERSCHMIDTSESLERRUEGSEGGERGRUPEN JMLHCLJMES: The occurrence of sulfonamide-resistant pneumococci in clinical practice, Jr. Infect. Dis., 1943, lxxiii, 12-30. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: L. A. JULIANELLE; MORRIS SIEGELAffiliations: New York, N. Y.*Received for publication March 11, 1944.From the Division of Infectious Diseases, The Public Health Research Institute of The City of New York, Inc.Aided by a grant from the Metropolitan Life Insurance Company on the recommendation of the Influenza-Pneumonia Commission.†Died, August 12, 1944.‡The antisera used for typing was graciously supplied by the Lederle Laboratories and the Bureau of Laboratories of the New York City Health Department. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA review of the available literature on the pharynx and pharyngeal surgery for 1945 1 January 1945Volume 22, Issue 1Page: 29-39KeywordsChildrenEpidemiologyInfectious diseasesPharynxPneumococcusPrevention, policy, and public healthSulfonamideUpper respiratory tract infections ePublished: 1 December 2008 Issue Published: 1 January 1945 PDF downloadLoading ...