tbuckley/cabot-search huggingface dataset:
Long-term Clinical Outcomes After Fetal Cell Transplantation in Parkinson Disease
Authors: Danny Bega, Dimitri Krainc
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development
Authors: Elena Seiradake, Daniel del Toro, Daniel Nagel, Florian Cop, Ricarda Härtl, Tobias Ruff, Gönül Seyit-Bremer, Karl Harlos, Ellen Clare Border, Amparo Acker-Palmer, E. Yvonne Jones, Rüdiger Klein
Journal: Neuron (2014)

FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to reveal the distinct structural bases for FLRT-mediated cell adhesion and repulsion in neurons. We apply this knowledge to elucidate FLRT functions during cortical development. We show that FLRTs regulate both the radial migration of pyramidal neurons, as well as their tangential spread. Mechanistically, radial migration is controlled by repulsive FLRT2-Unc5D interactions, while spatial organization in the tangential axis involves adhesive FLRT-FLRT interactions. Further, we show that the fundamental mechanisms of FLRT adhesion and repulsion are conserved between neurons and vascular endothelial cells. Our results reveal FLRTs as powerful guidance factors with structurally encoded repulsive and adhesive surfaces.
Evolutionary History of Microsatellites in the Obscura Group of Drosophila
Authors: Mohamed A. F. Noor, Richard M. Kliman, Carlos A. Machado
Journal: Molecular Biology and Evolution (2001)

The evolutionary origins of microsatellites are not well understood. Some investigators have suggested that point mutations that expand repeat arrays beyond a threshold size trigger microsatellites to become variable. However, little empirical data has been brought forth on this and related issues. In this study, we examine the evolutionary history of microsatellites in six species within the obscura group of Drosophila, tracing changes in microsatellite alleles using both PCR product size and sequence data. We found little evidence supporting a general role of point mutations triggering initial microsatellite expansion, and no consistent threshold size for expansion was observed. Flanking region length variation was extensive when alleles were sequenced in distantly related species, and some species possessed altogether different repeat arrays between the same primer binding sites. Our results suggest extreme caution in using microsatellite allele sizes for phylogenetic analyses or to infer divergences between populations.
Mitral-Valve Prolapse
Authors: Joshua Wynne
Journal: New England Journal of Medicine (1986)

Although the auscultatory findings of mitral-valve prolapse have been known for a century, only 25 years have elapsed since the widespread recognition of the association of midsystolic clicks or late systolic murmurs (or both) with diverse clinical features, including atypical chest pain, palpitations, stroke, endocarditis, and sudden death. Mitral-valve prolapse is usually diagnosed in about 5 percent of the seemingly healthy population, but it has been reported in as many as 21 percent.1 This apparent epidemic is of such proportion that one wonders why the condition was not more widely appreciated before the 1960s. One explanation is that the auscultatory . . .
Pasteurella septica infection in respiratory disease.
Authors: R H Ellis
Journal: Thorax (1967)

Bacteria ofthegenusPasteurella arewellrecognizedintheveterinary worldas thecause of various diseases of domestic, farm,and wild animals, suchas fowlcholeraand epidemic haemorrhagic septicaemia of swineand cattle. Since theearliest reports ofhumaninfection from Europe, Schipper (1947) collected 21 cases recorded between 1919and1946:eight ofthese had infected bites, andsevenhadpulmonary infection. Ofthe37casesreviewed byOlsenandNeedham (1952) andseenattheMayoClinic, 35haddisease oftheupper andlowerrespiratory tract, and bronchiectasis was confirmed bybronchography in30.Pasteurella septica was recovered from bronchial aspirates butrarely fromsputum,and itwas considered thattheorganism was a secondaryinvader inpre-established bronchiectasis. In theUnitedKingdom,CawsonandTalbot(1955) reported two cases ofbronchiectasis infarmers secondarily infected withP.septica andsuggested catsanddogsas thecommonestsource-an observation supported by Smith(1955), who isolated itfromtonsillar swabsin54% of 111 Londondogs.Further case reportsby Bartley (1960), DeBoerandDumler(1963), Freigang and Elliott (1963), BrodieandHenderson (1963), and ManecheandToll(1964) confirm thatP.septica may appearinthesputumcultures ofpatients with chronic infection oftherespiratory tractfollowinganimal contact. Because itisan unusual finding, andinviewof therecentinterest showninzoonoses generally, eight casesencountered inGloucestershire during a four-year period arereported; insome ofthem theinfection may haveplayed an important part inthecurrentacuterespiratory illness.
Pharmacogenomics — Ready for Prime Time?
Authors: Susan B. Shurin, Elizabeth G. Nabel
Journal: New England Journal of Medicine (2008)

It cannot be emphasized too strongly that treatment of each patient is a highly individualized matter.— FDA-approved labeling for warfarin (Coumadin) NDA 9-218/5-105Pharmacogenomics is receiving a great deal of attention in scientific circles and, increasingly, in the popular press because of the promise of personalized medicine. Short of being able to cure an illness or to prevent one, every clinician's dream is to offer patients a precisely targeted drug at a precisely calibrated dose to address a specific ailment — and to do so without wreaking havoc on the rest of the body. We have ample reason to . . .
Genome-Wide Loss of Heterozygosity and Copy Number Analysis in Melanoma Using High-Density Single-Nucleotide Polymorphism Arrays
Authors: Mitchell Stark, Nicholas Hayward
Journal: Cancer Research (2007)

Abstract Although a number of genes related to melanoma development have been identified through candidate gene screening approaches, few studies have attempted to conduct such analyses on a genome-wide scale. Here we use Illumina 317K whole-genome single-nucleotide polymorphism arrays to define a comprehensive allelotype of melanoma based on loss of heterozygosity (LOH) and copy number changes in a panel of 76 melanoma cell lines. In keeping with previous reports, we found frequent LOH on chromosome arms 9p (72%), 10p (55%), 10q (55%), 9q (49%), 6q (43%), 11q (43%), and 17p (41%). Tumor suppressor genes (TSGs) can be identified through homozygous deletion (HD). We detected 174 HDs, the most common of which targeted CDKN2A (n = 33). The second highest frequency of HD occurred in PTEN (n = 8), another well known melanoma TSG. HDs were also common for PTPRD (n = 7) and HDAC4 (n = 3), TSGs recently found to be mutated or deleted in other cancer types. Analysis of other HDs and regions of LOH that we have identified might lead to the characterization of further melanoma TSGs. We noted 197 regional amplifications, including some centered on the melanoma oncogenes MITF (n = 9), NRAS (n = 3), BRAF (n = 3), and CCND1 (n = 3). Other amplifications potentially target novel oncogenes important in the development of a subset of melanomas. The numerous focal amplifications and HDs we have documented here are the first step toward identifying a comprehensive catalog of genes involved in melanoma development, some of which may be useful prognostic markers or targets for therapies to treat this disease. [Cancer Res 2007;67(6):2632–42]
The international vision of the Journal of Hepatology
Authors: Didier Samuel
Journal: Journal of Hepatology (2012)

For the second consecutive year, the impact factor of the Journal is over 9, at 9.26, reflecting the huge improvement in its visibility. The Journal of Hepatology is undoubtedly among the top international journals in the field of Hepatology. We are willing to receive and publish original papers from all over the world. Our aim is to select the best papers, whatever their country of origin. This achievement is clearly shown by the origin of the submitted original manuscripts: 42%, 37%, 14% and 7% are from Asia, Europe, USA and English speaking countries (Canada and Australia) and others, respectively. 23%, 54%, 20% and 3% of the published manuscripts are from Asia, Europe, USA and English speaking countries (Canada and Australia) and others, respectively. The Journal of Hepatology is, with the annual International Liver Congress™, the flag of EASL. In addition, our goal is to have a balanced representation of clinical and basic research. The main criteria for our choices are excellence, originality, interest and quality. Our editorial team aims at developing the relationship between basic science and clinical application, and at giving our readers the most updated information on the scientific progress in Hepatology. This feature is particularly highlighted in our invited reviews and within the 2 sections Clinical Applications of Basic Science and Snapshots in Hepatology. We have paid particular attention to the quality of our invited reviews and I wish to thank the authors who provided updated and top-notch reviews either in clinical or basic science fields. Moreover, with the regular publications of the EASL Clinical Practice Guidelines, we provide our readers with a large overview in Hepatology, from basic aspects to clinical application and therapeutic guidelines. The Journal is also adapting to the new media, with the development, over the last year, of a new website, with bimonthly updated web content, and monthly videocasts. The new EASL membership will offer the possibility to get either the e-version of the Journal alone or both the printed and e-versions. We are currently developing an iPad and tablet version of the Journal, which should be ready in 2013. Along the same lines, we will continue improving the layout of the Journal, and the quality of the papers, tables and figures published. I wish also to sincerely thank the team of co-Editors, associate Editors and special section Editors for the huge and high-quality work done in the last years. I wish to thank the editorial team in Geneva for their support, their highly professional input and their help in the constant improvement of the Journal. I also thank Mark Thursz, EASL Secretary General, and the governing board of EASL for the continuous support to our team. I do not forget that the quality of the Journal depends on the quality of the submitted papers and I hope to receive from authors their best articles. Finally, I thank our readers and sincerely hope you will continue to enjoy the Journal of Hepatology in 2013. We wish you all an Excellent Year 2013!
Genomic Medicine, Health Information Technology, and Patient Care
Authors: Christopher G. Chute, Isaac S. Kohane
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal vasoconstriction in naturally elicited fear and its habituation in baboons
Authors: A. W. ZBROZYNA
Journal: Cardiovascular Research (1976)

Journal Article Renal vasoconstriction in naturally elicited fear and its habituation in baboons Get access A. W. ZBROZYNA A. W. ZBROZYNA 2 From the Regional Primate Research Center, University of Washington, Seattle, Washington 98195, USA 2On leave from the Department of Physiology, University of Birmingham. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 10, Issue 3, May 1976, Pages 295–300, https://doi.org/10.1093/cvr/10.3.295 Published: 01 May 1976
REDUCED POSTPRANDIAL BLOOD GLUCOSE LEVELS IN RECENTLY DIAGNOSED NON-INSULIN DEPENDENT DIABETICS SECONDARY TO PHARMACOLOGICALLY INDUCED DELAYED GASTRIC EMPTYING
Authors: W. T. Phillips, J. G. Schwartz, C. A. McMahan, R. Blumhardt
Journal: Clinical Nuclear Medicine (1992)

S: APRIL 9–12, 1992 San Antonio Convention Center & Hyatt Regency Hotel SAN ANTONIO, TEXAS Southwestern Chapter Society of Nuclear Medicine SPECT/PET Nuclear Cardiology Symposium and 37th Annual Meeting: PDF Only
Gonadotropin stimulates ovarian renin-angiotensin system in the rabbit.
Authors: Y Yoshimura, N Koyama, M Karube, T Oda, M Akiba, A Yoshinaga, S Shiokawa, M Jinno, Y Nakamura
Journal: Journal of Clinical Investigation (1994)

The present study was undertaken to assess the role of ovarian renin-angiotensin system (RAS) in the preovulatory cascade induced by gonadotropin exposure. In the in vitro perfused rabbit ovaries, exposure to human chorionic gonadotropin (hCG) enhanced the secretion rate of angiotensin II (Ang II) within 1 h. The secretion rate reached maximal levels at 6 h and then declined thereafter. The intrafollicular Ang II content and renin-like activity were also significantly increased at 2 and 4 h after exposure to hCG, compared with control ovaries perfused with medium alone. The level of intrafollicular Ang II after hCG exposure significantly exceeded the concentration of Ang II in an equivalent volume of plasma. The addition of 1 microM captopril to the perfusate significantly inhibited the secretion rate of Ang II stimulated by hCG; however, captopril affected neither the ovulatory efficiency nor prostaglandin production in ovaries treated with hCG. Captopril significantly inhibited the resumption of meiosis in the ovulated ova and follicular oocytes stimulated by hCG. The administration of 100 micrograms Ang II at 2-h intervals to the perfusate reversed the inhibitory effects of captopril on hCG-induced oocyte maturation. In conclusion, these data indicate that gonadotropin stimulates renin-like activity and Ang II production in the rabbit ovary. Ovarian renin-angiotensin system may play an important role in the process of oocyte maturation after exposure to gonadotropin.
Monoclonal antibody therapies targeting immune checkpoints induce fatal anaphylactic reactions in a murine model of breast cancer
Authors: Christine Mall, Gail D Sckisel, Annie Mirsoian, Steven K Grossenbacher, William J Murphy
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Co-inhibitory molecules such as PD1, PD-L1 and CTLA-4 are being increasingly used as targets of therapeutic intervention against cancer. The use of monoclonal antibodies targeting these immune checkpoints has been shown to promote anti-tumor immune responses clinically. While
A Comparison of Serum Immunoglobulin Concentrations in Sarcoidosis and Tuberculosis
Authors: C. E. BUCKLEY
Journal: Annals of Internal Medicine (1970)

Changes in the three major immunoglobulins in patients with sarcoidosis and tuberculosis were studied with respect to age, race, and sex. IgG and IgM were increased in patients with sarcoidosis, IgG in patients with tuberculosis. Differences between serum immunoglobulin concentrations in patients with sarcoidosis and tuberculosis were not significant. The restriction of significant hyperglobulinemia to specific race and sex combinations was of special interest. In patients with sarcoidosis the increase in IgG was significant in white patients, and the increase in IgM was significant only in black patients. A similar race-associated pattern could be demonstrated in patients with tuberculosis. Evaluation of hyperglobulinemia with respect to sex showed that the increase in IgM in sarcoidosis was only significant in black women. White men with tuberculosis showed increased IgG and IgA. Changes observed in specific race and sex combinations may provide a basis for interrelating these differences with variations in the natural history of each disease.
Beta-adrenoceptor-blocking drugs and blood sugar control in diabetes mellitus.
Authors: A D Wright, S G Barber, M J Kendall, P H Poole
Journal: BMJ (1979)

The effects on diabetic control of the relative cardioselective beta-blocker metoprolol and the non-selective drug propranolol were compared in 20 hypertensive diabetic patients receiving diet alone or diet and oral hypoglycaemic agents. Each drug was given for one month in a double-blind, cross-over study. Fasting, noon, and mid-afternoon blood sugar concentrations rose by 1.0-1.5 mmol/l (18-27 mg/100 ml). The rise with propranolol was not significantly greater than with metoprolol. In a few patients the rise was clinically important. The small overall change observed in diabetic control should not deter the use of beta-blockers in non-insulin-dependent diabetics, provided control is carefully monitored at the onset of treatment.
Case-control cancer mortality study and chlorination of drinking water in Louisiana.
Authors: M S Gottlieb, J K Carr
Journal: Environmental Health Perspectives (1982)

Several Louisiana parishes (counties) using the Mississippi River for their source of public drinking water have the highest mortality rates (1950-69) in the United States for several cancers. Therefore, a case-control mortality study on cancer of the liver, brain, pancreas, bladder, kidney, prostate, rectum, colon, esophagus, stomach, non-Hodgkin's lymphoma, multiple myeloma, leukemia, Hodgkin's disease, lung; breast and malignant melanoma, from 1960 to 1975 in South Louisiana parishes grouped for similarities in industrial characteristics, having approximately equal exposure of the population to surface and groundwater, was conducted. Noncancer deaths were randomly selected as controls and matched to the case death on age, race, sex, and year and parish group of death. Water source at death was assigned based on the residence at death and described as surface or ground and chlorinated or nonchlorinated. A significantly increased risk for surface, chlorinated water use was noted for rectal cancer. No risk could be demonstrated for colon cancer. The risk noted for bladder cancer by other investigators is not substantiated. Brain cancer risk appears to be associated with chlorinated groundwater, but this may be industrial confounding. Breast cancer demonstrated a slight, but significant, risk associated with surface chlorinated water. This risk, however, might be due to confounding of rural life style, early childbearing and large families with nonchlorinated water found in these settings. Chlorination risk for kidney cancer was not significant. No risk was observed in association with surface water for other cancers of the gastrointestinal or urinary tract. Multiple myeloma was significantly associated with a risk from ground water.
Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1∗01
Authors: Beatrice Jahn-Schmid, Gottfried F. Fischer, Barbara Bohle, Ingrid Faé, Gabriele Gadermaier, Azra Dedic, Fatima Ferreira, Christof Ebner
Journal: Journal of Allergy and Clinical Immunology (2005)
Intrahepatic and circulating HLA class II-restricted, hepatitis C virus-specific T cells: Functional characterization in patients with chronic hepatitis C
Authors: Amalia Penna, Gabriele Missale, Vincenzo Lamonaca, Massimo Pilli, Cristina Mori, Paola Zanelli, Albertina Cavalli, Gianfranco Elia, Carlo Ferrari
Journal: Hepatology (2002)

To compare the functional features of circulating and intrahepatic hepatitis C virus (HCV)-specific CD4+ T cells in chronic HCV infection, peripheral blood and liver-infiltrating lymphocytes from 29 patients with chronic hepatitis C were stimulated with structural and nonstructural HCV proteins to produce antigen-specific T-cell lines and clones. Antigen specificity, fine specificity, phenotype, cytokine production, and T-cell receptor (TCR)-vβ chain expression were analyzed. The results indicate a hierarchy of stimulatory capacity by the different HCV proteins, core being the antigen most frequently recognized by CD4+ intrahepatic lymphocytes, followed by NS4 and NS5. The CD4 response was directed simultaneously against different HCV proteins in individual patients, but fine-specificity analysis indicated that the response was generally focused on a limited number of immunodominant epitopes. Although the narrowly focused nature of this response may favor the emergence of escape mutations, this event was not observed by following-up over time the sequence of 2 epitopes strongly immunodominant for intrahepatic CD4 cells of a patient with chronic HCV infection. In conclusion, simultaneous analysis of peripheral blood and intrahepatic CD4 cells in the same patients indicated a predominant Th1 profile of HCV-specific CD4 cells and suggests a specific compartmentalization of virus-specific T cells into the liver.
The first and last days of medical school
Authors: Farrah J Mateen
Journal: BMJ (2005)

On my father's first day of medical school, so I am told, the dean of medicine, perched high on a stage, looked down on the eager group of new recruits and instructed: “Look to your left.” They did so.

“Look to your right.” They did that too.

“Someone sitting beside you will not be seen at convocation, unless, of course, that person is you.” The dean, in self fulfilling prophecy, turned out to be correct each year.

In contrast, my first day at medical school involved a barbeque, and the faculty volunteered to cook. I have never heard …