<i>Helicobacter pylori</i> Eradication Therapy for Nonulcer Dyspepsia
Authors: Paul Moayyedi, Jonathan Deeks, David Forman
Journal: Annals of Internal Medicine (2002)

Letters2 April 2002Helicobacter pylori Eradication Therapy for Nonulcer DyspepsiaPaul Moayyedi, Jonathan Deeks, and David FormanPaul MoayyediGeneral Infirmary at Leeds; Leeds LS1 3EX, United Kingdom (Moayyedi)Institute of Health Sciences; Oxford OX3 7LF, United Kingdom (Deeks)University of Leeds; Leeds LS2 9LN, United Kingdom (Forman)Search for more papers by this author, Jonathan DeeksGeneral Infirmary at Leeds; Leeds LS1 3EX, United Kingdom (Moayyedi)Institute of Health Sciences; Oxford OX3 7LF, United Kingdom (Deeks)University of Leeds; Leeds LS2 9LN, United Kingdom (Forman)Search for more papers by this author, and David FormanGeneral Infirmary at Leeds; Leeds LS1 3EX, United Kingdom (Moayyedi)Institute of Health Sciences; Oxford OX3 7LF, United Kingdom (Deeks)University of Leeds; Leeds LS2 9LN, United Kingdom (Forman)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-7-200204020-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We were interested to read the systematic review by Laine and colleagues (1) suggesting that Helicobacter pylori eradication therapy was not effective in nonulcer dyspepsia. We previously published a systematic review within the Cochrane Collaboration that reached a different conclusion (2), namely, that H. pylori eradication was associated with an increase in cure of symptoms in nonulcer dyspepsia. The effect size we observed was modest (reduction in dyspepsia rate, 9% [95% CI, 5% to 14%]) but statistically significant (P < 0.001), and an economic analysis suggested that H. pylori eradication may be cost-effective in patients with nonulcer ...References1. Laine L, Schoenfeld P, Fennerty MB. Therapy for Helicobacter pylori in patients with nonulcer dyspepsia. A meta-analysis of randomized, controlled trials. Ann Intern Med. 2001;134:361-9. [PMID: 11242496] LinkGoogle Scholar2. Moayyedi P, Soo S, Deeks J, Delaney B, Harris A, Innes M, et al . The Cochrane Library. Oxford: Update Software; 2000:4. Google Scholar3. Moayyedi P, Soo S, Deeks J, Forman D, Mason J, Innes M, et al . Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia. Dyspepsia Review Group. BMJ. 2000;321:659-64. [PMID: 10987767] CrossrefMedlineGoogle Scholar4. Koeltz HR, Arnold R, Stolte M, Blum AL. Treatment of Helicobacter pylori (HP) does not improve symptoms of functional dyspepsia (FD) [Abstract]. Gastroenterology. 1998;114:A182. CrossrefGoogle Scholar5. Deeks JJ, Altman DG. Effect measures for meta-analysis of trials with binary outcomes.. In: Egger M, Smith GD, Altman DG, eds. Systematic Reviews in Health Care: Meta-Analysis in Context. 2nd ed. London: BMJ; 2001:313-35. Google Scholar Author, Article, and Disclosure InformationAffiliations: General Infirmary at Leeds; Leeds LS1 3EX, United Kingdom (Moayyedi)Institute of Health Sciences; Oxford OX3 7LF, United Kingdom (Deeks)University of Leeds; Leeds LS2 9LN, United Kingdom (Forman) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTherapy for Helicobacter pylori in Patients with Nonulcer Dyspepsia Loren Laine , Philip Schoenfeld , and M. Brian Fennerty Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia Ward B. Buckingham Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia John M. Bozdech Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia Loren Laine , M. Brian Fennerty , and Philip Schoenfeld Metrics Cited byAn Update of The Cochrane Systematic Review of Helicobacter Pylori Eradication Therapy in Nonulcer Dyspepsia: Resolving The Discrepancy Between Systematic ReviewsDiagnostic methods for Helicobacter pylori detection and eradicationHelicobacter pylori eradication in non-ulcer dyspepsia: the case forHelicobacter pylori and nonmalignant disease 2 April 2002Volume 136, Issue 7Page: 555KeywordsHelicobacter pyloriOdds ratioRisk ratioSystematic reviews ePublished: 2 April 2002 Issue Published: 2 April 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...