tbuckley/cabot-search huggingface dataset:
On Procreative Power
Authors: C. H. F. Routh
Journal: BMJ (1850)

ON PBOC EATIVK POWZE.Pressure.During the night, the pin returned, inditedby howling ad restlessness.There were sevenl evacuations of fiees and urine.The following morning, there ws great prostration with much fever, and continued howling.The limb was slghtly emphysematous, greatly swollen, inflamed, and infiltrated with serum.On the following day, two ounces and a half of water, in which some nux vomica had been boiled, were injected into the crural artery of the opposite limb.The dog expressed no panm; but, at the expiration of ten or twelve minutes, slight convulsive motions became evident, which were gradually converted into violent tetanic spasms.The animal threw himself backwards with'his limbs extended, and died, after repeated convulsive attacks, an hour and a half after the last injection.Pos-mortem appearantces.On opening the body, no unusual apparances were obsered in the limb upon which the last experiment had been tried, but the opposite one was tud and emphysematous, infiltrated with a greyish red frothy serum of a fetid odour.The anall vessels wefre obstructed byfirm clots of blood.The gall-bladderwas greatly distended; and the intestinalnal contained a quantity of yellowish mucus.(To be cntimed.)ON PROCREATIVE POWER.
Serum 25-Hydroxyvitamin D and Cancer Mortality in the NHANES III Study (1988–2006)
Authors: D. Michal Freedman, Anne C. Looker, Christian C. Abnet, Martha S. Linet, Barry I. Graubard
Journal: Cancer Research (2010)

Abstract Vitamin D has been hypothesized to protect against cancer. We followed 16,819 participants in NHANES III (Third National Health and Nutritional Examination Survey) from 1988 to 2006, expanding on an earlier NHANES III study (1988–2000). Using Cox proportional hazards regression models, we examined risk related to baseline serum 25-hydroxyvitamin D [25(OH)D] for total cancer mortality, in both sexes, and by racial/ethnic groups, as well as for site-specific cancers. Because serum was collected in the south in cooler months and in the north in warmer months, we examined associations by collection season (“summer/higher latitude” and “winter/lower latitude”). We identified 884 cancer deaths during 225,212 person-years. Overall cancer mortality risks were unrelated to baseline 25(OH)D status in both season/latitude groups, and in non-Hispanic whites, non-Hispanic blacks, and Mexican-Americans. In men, risks were elevated at higher levels {e.g., for ≥100 nmol/L, relative risk (RR) = 1.85 [95% confidence interval (CI), 1.02–3.35] compared with &amp;lt;37.5 nmol/L}. Although risks were unrelated to 25(OH)D in all women combined, risks significantly decreased with increasing 25(OH)D in the summer/higher latitude group [for ≥100 nmol/L, RR = 0.52 (95% CI, 0.25–1.15) compared with &amp;lt;37.5 nmol/L; Ptrend = 0.03, based on continuous values]. We also observed a suggestion of an inverse association with colorectal cancer mortality (Ptrend = 0.09) and a positive association with lung cancer mortality among males (Ptrend = 0.03). Our results do not support the hypothesis that 25(OH)D is associated with reduced cancer mortality. Although cancer mortality in females was inversely associated with 25(OH)D in the summer/higher latitude group, cancer mortality at some sites was increased among men with higher 25(OH)D. These findings argue for caution before increasing 25(OH)D levels to prevent cancer. Cancer Res; 70(21); 8587–97. ©2010 AACR.
Hemolytic Anemia Caused by G-6-PD Carswell, A New Variant
Authors: NORMAN H. SIEGEL
Journal: Annals of Internal Medicine (1971)

An 18-year-old man of Irish ancestry was found to have hemolytic anemia associated with a deficiency of red-cell glucose-6-phosphate dehydrogenase. Characterization of the partially purified enzyme showed it to differ from previously described variants. It was electrophoretically slow, showed decreased activity with deamino nicotinamide-adenine dinucleotide phosphate (NADP), and was stable to heat. The abnormal enzyme has been named G-6-PD Carswell.
The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles
Authors: Kee Woei Ng, Stella P.K. Khoo, Boon Chin Heng, Magdiel I. Setyawati, Eng Chok Tan, Xinxin Zhao, Sijing Xiong, Wanru Fang, David T. Leong, Joachim S.C. Loo
Journal: Biomaterials (2011)
Clinical Nuclear Medicine
Authors: Robert E. Henkin
Journal: JAMA (1984)

It is always considered a major event when a new nuclear medicine text appears in the catalogues. The editors of a nuclear medicine text must indeed be brave persons. They know in advance that they cannot satisfy everyone and will slight either radiopharmacist, physicist, or clinician with their presentation. With the rapid progression of nuclear medicine they are also usually aware that their text will be outdated before they ever publish it. We should therefore be grateful that there are enough of these brave persons who will occasionally venture into this hazardous environment to produce a text. <i>Clinical Nuclear Medicine</i>is directed toward the clinical practice of this specialty. As such, it is weighted quite heavily toward the practitioner and deals peripherally with theoretical aspects of instrumentation and radiopharmaceutical chemistry. The 21 clinical chapters are well written and contain extensive information. In fact, the only serious criticism that can be
Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease
Authors: Mark N. Polizzotto, Thomas S. Uldrick, Victoria Wang, Karen Aleman, Kathleen M. Wyvill, Vickie Marshall, Stefania Pittaluga, Deirdre O’Mahony, Denise Whitby, Giovanna Tosato, Seth M. Steinberg, Richard F. Little, Robert Yarchoan
Journal: Blood (2013)
Congestive Heart Failure and Thoracentesis
Authors: Yizhak Kupfer, Sidney Tessler
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 April 1986Congestive Heart Failure and ThoracentesisYIZHAK KUPFER, B.A., SIDNEY TESSLER, M.D.YIZHAK KUPFER, B.A.Search for more papers by this author, SIDNEY TESSLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-4-584_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The position paper on thoracentesis and pleural effusions (1), in the November issue, states that thoracentesis is indicated in all patients with pleural effusions of unknown cause except in a "patient presenting with clear clinical manifestations of recurrent left ventricular failure" in whom "a trial of diuresis might precede consideration of thoracentesis." We question the strength of the association between left ventricular failure alone and pleural effusions.Most transudative effusions associated with congestive heart failure occur in patients with biventricular failure with consequent elevations of both the systemic and pulmonary venous pressures (2). Mellins and colleagues (3)...References1. . Diagnostic thoracentesis and pleural biopsy in pleural effusions. Ann Intern Med. 1985;103:799-802. LinkGoogle Scholar2. CHETTY K. Transudative pleural effusions. Clin Chest Med. March 1985;6:49-54. CrossrefMedlineGoogle Scholar3. MELLINSLEVINEFISHMAN ROA. Effects of systemic and pulmonary venous hypertension on pleural and pericardial fluid accumulation. J Appl Physiol. 1970;29:564-9. CrossrefMedlineGoogle Scholar4. MCPEAKLEVINE ES. The preponderance of right hydrothorax in congestive heart failure. Ann Intern Med. 1946;25:916-27. LinkGoogle Scholar5. WEISSSPODICK JD. Laterality of pleural effusions in chronic congestive heart failure. Am J Cardiol. 1984;53:951. CrossrefMedlineGoogle Scholar6. PILLAY V. Total proteins in serous fluids in cardiac failure. S Afr Med J. 1965;39:142-3. MedlineGoogle Scholar1. MELLINSLEVINEFISHMAN ROA. Effect of systemic and pulmonary venous hypertension on pleural and pericardial fluid accumulation. J Appl Physiol. 1970;29:564-9. CrossrefMedlineGoogle Scholar2. . Diagnostic thoracentesis and pleural biopsy in pleural effusions. Ann Intern Med. 1986;104:799-802. Google Scholar3. PILLAY V. Total proteins in serous fluids in cardiac failure. S Afr Med J. 1965;39:142-3. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTreatment of Congestive Heart Failure 1 April 1986Volume 104, Issue 4Page: 584-585KeywordsClinical trialsHeart failurePleural effusion Issue Published: 1 April 1986 PDF DownloadLoading ...
Boosting VA Clinician Supply
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Placental and mammary transfer of sulphasalazine.
Authors: A K Khan, S C Truelove
Journal: BMJ (1979)

This dramatic but rare fatal complication of mitral valve disease should not be dismissed as a mere academic curiosity.With increasing use of slow-release potassium tablets it may become more common.One of the patients described by Whitney and Croxon died of gastro- intestinal haemorrhage and two of their patients had sufficient dysphagia to need feeding jejunostomies.In view of all this it seems desirable to use effervescent potassium chloride or potassium chloride mixture rather than potassium chloride tablets in patients with chronic mitral valve disease complicated by left atrial dilation.
Hypokalaemia and xipamide
Authors: J Bentley
Journal: BMJ (1982)

Hypokalaemia and xipamide SIR,-I read the paper entitled "Ventricular fibrillation induced by xipamide" (13 February, p 494) with great interest.We published a paper from this department in 1981,1 in which we drew attention to the fact that xipamide, although a very effective antihypertensive agent, caused profound re- ductions in the serum potassium concentra- tions, which were potentially dangerous, and recommended that it should not be used for this purpose unless adequate potassium supplements were given at the same time.'It is not clear to me, however, why the authors have included indapamide in their indictment of xipamide since their case report refers to a patient who was simply taking the latter drug and not the former.There are some chemical similarities between the two drugs, in that both are derivatives of chlorosulphonamide (xipamide is a salicylic acid derivative and indapamide an indoline derivative) but there would appear to be substantial pharma- cological differences between the two.Xipamide is undoubtedly a potent diuretic,2
Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study
Authors: Marie L Ancelin, Sylvaine Artero, Florence Portet, Anne-Marie Dupuy, Jacques Touchon, Karen Ritchie
Journal: BMJ (2006)

<b>Background:</b> Little information is available in Canada about the prevalence of and outcomes associated with a history of slapping and spanking in childhood. The objectives of this study were to estimate the prevalence of a history of slapping or spanking in a general population sample and to assess the relation between such a history and the lifetime prevalence of psychiatric disorders. <b>Methods:</b> In this general population survey, a probability sample of 9953 residents of Ontario aged 15 years and older who participated in the Ontario Health Supplement was used to examine the prevalence of a history of slapping and spanking. A subgroup of this sample (<i>n</i> = 4888), which comprised people aged 15 to 64 years who did not report a history of physical or sexual abuse during childhood, was used to assess the relation between a history of slapping or spanking and the lifetime prevalence of 4 categories of psychiatric disorder. The measures included a self-administered questionnaire with a question about frequency of slapping and spanking during childhood, as well as an interviewer-administered questionnaire to measure psychiatric disorder. <b>Results:</b> The majority of respondents indicated that they had been slapped or spanked, or both, by an adult during childhood "sometimes" (33.4%) or "rarely" (40.9%); 5.5% reported that this occurred "often." The remainder (20.2%) reported "never" experiencing these behaviours. Among the respondents without a history of physical or sexual abuse during childhood, those who reported being slapped or spanked "often" or "sometimes" had significantly higher lifetime rates of anxiety disorders (adjusted odds ratio [OR] 1.43, 95% confidence interval [CI] 1.04-1.96), alcohol abuse or dependence (adjusted OR 2.02, 95% CI 1.27-3.21) and one or more externalizing problems (adjusted OR 2.08, 95% CI 1.36-3.16), compared with those who reported "never" being slapped or spanked. There was also an association between a history of slapping or spanking and major depression, but it was not statistically significant (adjusted OR 1.64, 95% CI 0.96-2.80). <b>Interpretation:</b> There appears to be a linear association between the frequency of slapping and spanking during childhood and a lifetime prevalence of anxiety disorder, alcohol abuse or dependence and externalizing problems.
A quarter of waiting time records are wrong, finds English watchdog
Authors: H. Mooney
Journal: BMJ (2014)

Hospitals are incorrectly recording the waiting times for treatment for over a quarter of all patients, the public spending watchdog has found.

A report from the National Audit Office into NHS waiting times for elective care in England has shown that many hospitals are not correctly recording how long patients have to wait before having planned treatment.

The National Audit Office found errors in recording the wait experienced by over a quarter of all patients. Its review of a sample of 650 orthopaedic cases at seven hospital trusts in England also found that in nearly 32% of cases waiting times were not supported by enough evidence to …
Africa Needs More Aid, New Partnerships to Fight Malaria
Authors: R. Voelker
Journal: JAMA (2000)

A conference that gathered 35 African health ministers was held in the US to develop new partnerships with industrialized nations to fight HIV/AIDS and malaria.  It was organized by the Atlanta-based American Medical Team for Africa a nonprofit group that provides medical supplies and training for poor African nations.  During the conference Swazilands minister pleaded for action to break down bureaucratic obstacles to obtaining international aid.  More specifically the ministers urged the US to allocate US$10 billion during the next 5 years to fight HIV/AIDS and malaria in Africa. The ministers also asked that Japan and countries of the European Union provide matching funds.  In addition the establishment of an international coalition of donors that would create a pool from which African countries could buy drugs based on their ability to pay was suggested as a more efficient way to access funds for medications.  Other ideas for collaboration discussed during the conference were aimed at using technologies to improve access to medical care in Africa.
Interferon alpha-2b alone or combined with recombinant granulocyte-macrophage colony-stimulating factor as treatment of chronic hepatitis C
Authors: Karin Groenbaek, Henrik Krarup, Helmer Ring-Larsen, Ove Schaffalitzsky de Muckadell, Axel Moeller, Poul Schlicting, Mogens Vyberg
Journal: Journal of Hepatology (2002)
Travel medicine and general practice: a suitable case for audit?
Authors: D S Sloan
Journal: BMJ (1993)

Travel medicine becomes more important with the continual expansion of international travel and the increased popularity of exotic holiday destinations. In the United Kingdom general practitioners provide the bulk of travel health advice and immunisation and there is growing interest in providing these services. While their armamentarium has been expanded with attractive but expensive new vaccines, the need for health service advice has never been more vital, with the risks of HIV infection and drug resistant malaria. Advantages of a general practice based travel medicine service include maintaining continuity of care for the patient, but a disadvantage might be that the general practitioner sees too few patients to acquire enough skill in the subject. Furthermore, there may be a conflict of interest between time devoted to the "vaccination ritual" and giving health advice. Overall there seems to be a case for both audit and support by the health authorities.
Tensions in the Racial Integration of Health Care, Then and Now: Reply
Authors: P. Preston Reynolds
Journal: Annals of Internal Medicine (1998)

Letters15 January 1998Tensions in the Racial Integration of Health Care, Then and Now: ReplyP. Preston Reynolds, MD, PhDP. Preston Reynolds, MD, PhDJohns Hopkins University; Baltimore, MD 21205Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-2-199801150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The Supreme Court receives almost 5000 petitions for certiorari each year. The 150 cases selected for full review and argument by the Supreme Court generally involve important constitutional principles or are likely to reverse a lower court ruling [1].The Simkins v Moses H. Cone Memorial Hospital case, although receiving a denial of certiorari by the Supreme Court, was considered in 1963 a landmark decision for Chief Judge Simon E. Sobeloff of the 4th Circuit Court of Appeals. Judge Sobeloff received letters of accolade from citizens and esteemed law colleagues. Initially, the five circuit-court judges voted three against ...References1. Ions P, Guitton S. May It Please the Court. New York: WW Norton; 1993. Google Scholar2. #8908: Simkins versus Moses Cone Hospital file. Simon E. Sobeloff manuscripts. Located at National Library of Congress, Washington, DC. Google Scholar3. Rowan CT. Dream Makers, Dream Breakers: The World of Justice Thurgood Marshall. Boston: Little, Brown; 1993. Google Scholar4. Branch T. Parting the Waters: American in the King Years, 1954-1963. New York: Simon & Schuster; 1988. Google Scholar5. Evers C, Szanton A. Have No Fear: A Black Man's Fight for Respect in America. New York: Wiley & Sons; 1997. Google Scholar Author, Article, and Disclosure InformationAuthors: P. Preston Reynolds, MD, PhDAffiliations: Johns Hopkins University; Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1998Volume 128, Issue 2Page: 158KeywordsHealth careHealth care qualityHealth insuranceRacial and ethnic issuesSocioeconomic status ePublished: 15 August 2000 Issue Published: 15 January 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Global Mortality Estimates for the 2009 Influenza Pandemic from the GLaMOR Project: A Modeling Study
Authors: Lone Simonsen, Peter Spreeuwenberg, Roger Lustig, Robert J. Taylor, Douglas M. Fleming, Madelon Kroneman, Maria D. Van Kerkhove, Anthony W. Mounts, W. John Paget
Journal: PLoS Medicine (2013)

Background Assessing the mortality impact of the 2009 influenza A H1N1 virus (H1N1pdm09) is essential for optimizing public health responses to future pandemics. The World Health Organization reported 18,631 laboratory-confirmed pandemic deaths, but the total pandemic mortality burden was substantially higher. We estimated the 2009 pandemic mortality burden through statistical modeling of mortality data from multiple countries. Methods and Findings We obtained weekly virology and underlying cause-of-death mortality time series for 2005–2009 for 20 countries covering ∼35% of the world population. We applied a multivariate linear regression model to estimate pandemic respiratory mortality in each collaborating country. We then used these results plus ten country indicators in a multiple imputation model to project the mortality burden in all world countries. Between 123,000 and 203,000 pandemic respiratory deaths were estimated globally for the last 9 mo of 2009. The majority (62%–85%) were attributed to persons under 65 y of age. We observed a striking regional heterogeneity, with almost 20-fold higher mortality in some countries in the Americas than in Europe. The model attributed 148,000–249,000 respiratory deaths to influenza in an average pre-pandemic season, with only 19% in persons <65 y. Limitations include lack of representation of low-income countries among single-country estimates and an inability to study subsequent pandemic waves (2010–2012). Conclusions We estimate that 2009 global pandemic respiratory mortality was ∼10-fold higher than the World Health Organization's laboratory-confirmed mortality count. Although the pandemic mortality estimate was similar in magnitude to that of seasonal influenza, a marked shift toward mortality among persons <65 y of age occurred, so that many more life-years were lost. The burden varied greatly among countries, corroborating early reports of far greater pandemic severity in the Americas than in Australia, New Zealand, and Europe. A collaborative network to collect and analyze mortality and hospitalization surveillance data is needed to rapidly establish the severity of future pandemics. Please see later in the article for the Editors' Summary
Morphometry of the Human Pulmonary Arterial Tree
Authors: SIAM SINGHAL, ROBERT HENDERSON, KEITH HORSFIELD, KEITH HARDING, GORDON CUMMING
Journal: Circulation Research (1973)

From a cast of a human pulmonary arterial tree, the diameter, length, order, and end branches of all intact branches down to those 0.8 mm in diameter were measured and corrections for broken branches were made. A sample of structures smaller than these (0.8-0.1 mm) was similarly measured. The values for branches less than 0.1 mm in diameter were found by extrapolation and comparison with known data for the precapillary vessels. Therefore, data or estimates for each order of branching in the pulmonary tree were obtained and calculations of cross-sectional area, volume, and flow were made.