Thrombopoietin: Platelets on Demand
Authors: Kenneth Kaushansky
Journal: Annals of Internal Medicine (1997)

Editorials1 May 1997Thrombopoietin: Platelets on DemandKenneth Kaushansky, MDKenneth Kaushansky, MDUniversity of Washington, Seattle, WA 98195Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-9-199705010-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail We are still without a trustworthy medicine which can always be relied upon to control purpura.Sir William Osler, 1892In many respects, this dilemma is as poignant today as it was when it was first penned by the famous physician. Severe thrombocytopenia complicates the course of many patients with naturally occurring or iatrogenic states of bone marrow failure. Because more patients with cancer are now undergoing stem cell transplantation and aggressive therapy, the transfusion of platelet concentrates now exceeds that of red blood cells. Unfortunately, many problems often arise in patients receiving platelet transfusions; these include a high incidence ...References1. Wright JH. The origin and nature of the blood plates. Boston Medical and Surgical Journal. 1906; 23:643-5. Google Scholar2. Adamson JW. Regulation of red blood cell production. Am J Med. 1996; 101:45-65. Google Scholar3. Welte K, Gabrilove J, Bronchud MH, Platzer E, Morstyn G. Filgrastim (r-metHuG-CSF): the first ten years. Blood. 1996; 88:1907-29. Google Scholar4. Kelemen E, Cserhati I, Tanos B. Demonstration and some properties of human thrombopoietin in thrombocythemic sera. Acta Haematol (Basel). 1958; 20:350-5. Google Scholar5. Vigon I, Mornon JP, Cocault L, Mitjavila MT, Tambourin P, Gisselbrecht S, et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci U S A. 1992; 89:5640-4. Google Scholar6. Kaushansky K. 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Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Washington, Seattle, WA 98195Acknowledgment: The author thanks all of his collaborators who contributed to studies of thrombopoietin biology.Grant Support: In part by grants R01 DK 43719, R01 CA 31615, and R01 DK 49855 from the National Institutes of Health.Corresponding Author: Kenneth Kaushansky, MD, University of Washington, 1959 Northeast Pacific Street, Seattle, WA 98195. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoStimulation of Megakaryocyte and Platelet Production by a Single Dose of Recombinant Human Thrombopoietin in Patients with Cancer Saroj Vadhan-Raj , Lesley J. Murray , Carlos Bueso-Ramos , Shreyaskumar Patel , Saraswati P. Reddy , William K. Hoots , Taren Johnston , Nicholas E. Papadopolous , Walter N. Hittelman , Dennis A. Johnston , Timothy A. Yang , Virginia E. Paton , Robert L. Cohen , Susan D. Hellmann , Robert S. Benjamin , and Hal E. Broxmeyer Metrics Cited byHematopoietic Growth Factors in Transfusion MedicineHematopoietic Growth Factors in Transfusion MedicineHematologic Disorders Associated with Human Immunodeficiency Virus and AIDSHydroxyurea-associated Platelet Count Oscillations in Polycythemia Vera: A Report of Four New Cases and a ReviewPlateletsIn Vitro and in Vivo Properties of Various Types of Platelets 1 May 1997Volume 126, Issue 9Page: 731-733KeywordsBloodClinical trial reportingCloningCytokine receptorsDrug administrationDrugsErythropoietinGranulocyte colony stimulating factorHormonesPlatelets ePublished: 15 August 2000 Issue Published: 1 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...