tbuckley/cabot-search huggingface dataset:
Review: In diabetes with multivessel or left main CAD, PCI increases death/MI/stroke combo compared with CABG
Authors: Mark A. Hlatky
Journal: Annals of Internal Medicine (2015)

ACP Journal Club17 March 2015Review: In diabetes with multivessel or left main CAD, PCI increases death/MI/stroke combo compared with CABGMark A. Hlatky, MDMark A. Hlatky, MDStanford University School of Medicine, Stanford, California, USA (M.A.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2015-162-6-008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationTu B, Rich B, Labos C, Brophy JM. Coronary revascularization in diabetic patients: a systematic review and Bayesian network meta-analysis. Ann Intern Med. 2014;161:724-32. https://pubmed.ncbi.nlm.nih.gov/25402514Clinical Impact RatingsCardiology: Endocrinology: References1. Hlatky MA, Boothroyd DB, Baker L, et al. Comparative effectiveness of multivessel coronary bypass surgery and multivessel percutaneous coronary intervention: A cohort study. Ann Intern Med. 2013;158:727-34. [PMID: 23609014] Google Scholar2. Hlatky MA, Boothroyd DB, Baker LC, Go AS. Impact of drug-eluting stents on the comparative effectiveness of coronary artery bypass surgery and percutaneous coronary intervention. Am Heart J. 2015;169:149-54. [PMID: 25497260] Google Scholar Author, Article, and Disclosure InformationAuthors: Mark A. Hlatky, MDAffiliations: Stanford University School of Medicine, Stanford, California, USA (M.A.H.)This article was published at Annals.org on 3 March 2015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe quality of life of patients developed delirium after coronary artery bypass grafting is determined by cognitive function after discharge: A cross-sectional study 17 March 2015Volume 162, Issue 6Page: JC8KeywordsCoronary artery bypass graftingMortalityMyocardial infarctionNetwork analysisOdds ratioPercutaneous coronary interventionStable coronary artery diseaseStent implantationStrokeSystematic reviews ePublished: 17 March 2015 Issue Published: 17 March 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Liver transplantation of Budd-Chiari syndrome
Authors: C. W. Putnam
Journal: JAMA (1976)

Orthotopic liver transplantation was accomplished in a 22-year-old woman dying of the Budd-Chiari syndrome. She is well and has normal liver function 16 months postoperatively. In view of the good early result, it will be appropriate to consider liver replacement for this disease in further well-selected cases.
Sexual Education for Adolescents
Authors: Truman G. Esau
Journal: JAMA (1968)

An earnest young protestant seminary graduate has come to be an assistant minister in our suburban community. He wishes to undertake some sort of sexual education of the adolescent young people in the church, before they encounter the sexual temptations which are bound to arise in high school and college. If he undertakes this task in cooperation with one of the physicians in the congregation, what should be the role of each? Is it necessary to obtain the consent of the parents of the young people before such counseling is undertaken?
Palliative chemotherapy for advanced non-small cell lung cancer
Authors: I E Smith
Journal: BMJ (1994)

and especially those with palmoplantar pustular psoriasis.Prospective clinical studies are needed to see whether stopping smoking makes any difference to the course of established psoriasis.Quite possibly people might be more willing to change their habits because of a current and socially debilitating skin disorder than because of long term risks of cancer and ischaemic heart disease.
The therapeutic efficacy of conjugated linoleic acid – Paclitaxel on glioma in the rat
Authors: Xi-Yu Ke, Bo-Jun Zhao, Xin Zhao, Ying Wang, Yue Huang, Xiao-Mei Chen, Bing-Xiang Zhao, Shan-Shan Zhao, Xuan Zhang, Qiang Zhang
Journal: Biomaterials (2010)
Comparison of left atrial and left ventricular performance in conscious dogs
Authors: S. GOLDMAN, M. OLAJOS, E. MORKIN
Journal: Cardiovascular Research (1984)

Journal Article Comparison of left atrial and left ventricular performance in conscious dogs Get access STEVEN GOLDMAN, STEVEN GOLDMAN * From the Departments of Internal Medicine and Pharmacology, Veterans Administration Medical Center and University of Arizona Tucson, Arizona *Address correspondence and reprint requests to: Dr Steven Goldman, Veterans Administration Hospital, Tucson, Arizona, 85723, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar MARCEY OLAJOS, MARCEY OLAJOS From the Departments of Internal Medicine and Pharmacology, Veterans Administration Medical Center and University of Arizona Tucson, Arizona Search for other works by this author on: Oxford Academic PubMed Google Scholar EUGENE MORKIN EUGENE MORKIN From the Departments of Internal Medicine and Pharmacology, Veterans Administration Medical Center and University of Arizona Tucson, Arizona Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 10, October 1984, Pages 604–612, https://doi.org/10.1093/cvr/18.10.604 Published: 01 October 1984
Academic accommodation for post concussion student athletes: can physicians do better?
Authors: James Carson, Catherine Snow, David Lawrence, Sari Kraft, Ananda Chatterjee, Heather MacKenzie, Rahim Moineddin, Pierre Frémont
Journal: British Journal of Sports Medicine (2013)

Objective To determine the barriers and facilitators to the implementation of concussion related medical recommendations in a sport and school environment. Design Retrospective longitudinal chart review and structured telephone interviews. Setting A sport medicine physician's office in Ontario, Canada. Subjects 159 students with a sport-related concussion. Intervention The data collection involved a review of 170 charts of patients seen for concussion over a 5-year period (2006–2010). Two blinded authors independently reviewed each chart and SCAT or SCAT2 symptom self report form. In situations where there was discrepancy between the two reviewers results, a third author reviewed the charts. The telephone interviews supported the data collection. Outcome Measures Our primary outcome measures were (1) whether the patient returned to their sport too soon, or before they had fully recovered, and (2) whether the patient returned to school too soon, or before they had adequately recovered. The phone interview was structured to collect outcome measures providing insight into the patients' post-concussion course and recovery process. This will assist in determining what factors they believe improved their condition, or what slowed the recovery process. Results In terms of the primary outcomes, 43.53% of students returned to sport too soon and 44.71% returned to school too soon. Conclusions Currently, physicians advise restricted mental and physical activity, but no clear guideline exists explaining exactly what cognitive rest entails for post-concussion student athletes. Efforts are needed to find the best method of implementing a coordinated plan for the post-concussion athlete who is returning to school. Competing interests None.
Diethylstilbestrol Exposure And Lymphocytic Impairment
Authors: Richard J. Ablin
Journal: JAMA (1974)

To the Editor.—  The recent report 1 by Dr. Edward Shmunes, at the AMA Convention in Chicago, of the occurrence of gynecomastia, loss of libido, and hypospermia in chemical workers following accidental exposure to diethylstilbestrol suggested to us that communication of some preliminary results of studies in progress in our laboratory would be of interest.  It is well documented that administration of sex hormones, particularly estrogens, may result in alterations of lymphoid tissue and nonspecific as well as specific factors of cellularand humoral-mediated immunologic responsiveness (salient references 2 ). The effects of such therapy, notably in patients with hormonally dependent tumors, eg, of the breast and prostate, on the immunologic responsiveness of the host to malignant neoplasms have not, however, clearly been delineated. In this regard, our studies, although of a preliminary nature, have pointed to the suppression of one factor of cell-mediated immunologic competence thus far evaluated, that is, the ability
Status of women is central to reducing child mortality in India, report says
Authors: S. Arie
Journal: BMJ (2012)

<h3>Abstract</h3> DNA associated proteins (DAPs) classically regulate gene expression by binding to regulatory loci such as enhancers or promoters. As expanding catalogs of genome-wide DAP binding maps reveal thousands of loci that, unlike the majority of conventional enhancers and promoters, associate with dozens of different DAPs with apparently little regard for motif preference, an understanding of DAP association and coordination at such regulatory loci is essential to deciphering how these regions contribute to normal development and disease. In this study, we aggregated publicly available ChIP-seq data from 469 human DAPs assayed in three cell lines and integrated these data with an orthogonal dataset of 352 non-redundant, <i>in vitro</i>-derived motifs mapped to the genome within DNase hypersensitivity footprints in an effort to characterize regions of the genome that have exceptionally high numbers of DAP associations. We subsequently performed a massively parallel mutagenesis assay to search for sequence elements driving transcriptional activity at such loci and explored plausible biological mechanisms underlying their formation. We establish a generalizable definition for High Occupancy Target (HOT) loci and identify putative driver DAP motifs in HEPG2 cells, including HNF4A, SP1, SP5, and ETV4, that are highly prevalent and exhibit sequence conservation at HOT loci. The number of different DAPs associated with an element is positively associated with evidence of regulatory activity and, by systematically mutating 245 HOT loci, we localized regulatory activity to a central core region that depends on the motif sequences of our previously nominated driver DAPs. In sum, this work leverages the increasingly large number of DAP motif and ChIP-seq data publicly available to explore how DAP associations contribute to genome-wide transcriptional regulation.
Effect of Intraperitoneal Fibrinolysin on Reformation of Intestinal Adhesions
Authors: A. Stephen Close, W. Thomas Redfern, Michael Polacek, Emmanuel G. Balcos
Journal: JAMA (1963)

POSTOPERATIVE ADHESIONS are the commonest cause of mechanical small-bowel obstruction, and the prevention of such adhesions has been the subject of considerable investigation. A complete and excellent review of such studies appeared in<i>Surgery, Gynecology and Obstetrics</i>in May, 1960. Surgical lysis has been reported by one author to increase adhesions, by another to decrease them. Reperitonealization is of questionable benefit, and anticoagulants are probably more dangerous than useful. Lanolin and other lubricants have received clinical trials without benefit of preliminary study, and grafts of omentum and amnion are of questionable value and cumbersome to use. Studies have shown that promotion of early postoperative peristalsis by feeding, diathermy, or neostigmine (Prostigmin) is of questionable benefit. Results of intraperitoneal administration of streptokinase and streptodornase are inconclusive. Hyaluronidase may be of some value and deserves further investigation. Steroids have been reported to be effective. As pointed out by Connolly and Smith
Variations in Interpretation of Prescription Instructions
Authors: John M. Mazzullo
Journal: JAMA (1974)

Sixty-seven patients interpreted instructions on each of ten prescription labels. Not once was a label uniformly interpreted by all patients. Besides variability in the interpretation of imprecise instructions, frequent misinterpretation of explicit instructions occurred. With five prescriptions whose instructions were not ambiguous, the frequency of interpretive errors ranged from 9% to 64%. These observations illustrate the need for physicians to provide medication instructions that are consistent with the patient's daily activities and to review these instructions with the patient.
Fluocinolone acetonide 0.01% in peanut oil: Therapy for childhood atopic dermatitis, even in patients who are peanut sensitive
Authors: Amy S. Paller, Sai Nimmagadda, Lawrence Schachner, Susan B. Mallory, Teri Kahn, Isaac Willis, Lawrence F. Eichenfield
Journal: Journal of the American Academy of Dermatology (2003)
Septicemia in the Newborn
Authors: Charles D. Kimball
Journal: JAMA (1966)

<h3>To the Editor:—</h3> The editorial (<b>197</b>: 215, 1966) dealing with the increasing incidence of neonatal septicemia and meningitis due to<i>Escherichia coli</i>and other enteric organisms failed to mention one obvious source of infection. When attempting to insert a needle into the caudal canal of an obese patient with a fetal head deep in the pelvis, a less than expert anesthesiologist might, for example, be off less than 1 cm from the anatomical landmarks, yet perforate the sacrococcygeal ligament, rectum, vaginal wall, and the infant's scalp and enter the needle tip into the fontanelle or superior sagittal sinus. Needle puncture marks on newborn infant scalps and subcutaneous emphysema from air injection to test placement of the caudal needle have been observed. Paracervical and pudendal block injections conceivably carry a similar hazard of introducing enteric organisms into the fetal cranium and bloodstream prior to birth.
QUANTITATIVE JOINT SCANNING IN RHEUMATOID ARTHRITIS
Authors: M. B. Brachman, D. J. Wallace, E. Garcia, J. Klinenberg, D. E. Brown, D. E. Tanasescu, L. Ramanna, A. D. Waxman
Journal: Clinical Nuclear Medicine (1981)

Brachman, M. B.; Wallace, D. J.; Garcia, E.; Klinenberg, J.; Brown, D. E.; Tanasescu, D. E.; Ramanna, L.; Waxman, A. D. Author Information
SOCS3 Protein Developmentally Regulates the Chemokine Receptor CXCR4-FAK Signaling Pathway during B Lymphopoiesis
Authors: Yi Le, Bing-Mei Zhu, Brendan Harley, Shin-Young Park, Takashi Kobayashi, John P. Manis, Hongbo R. Luo, Akihiko Yoshimura, Lothar Hennighausen, Leslie E. Silberstein
Journal: Immunity (2007)
Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia
Authors: Paola T. Drapkin, Catherine R. O’Riordan, Su Min Yi, John A. Chiorini, Jonathan Cardella, Joseph Zabner, Michael J. Welsh
Journal: Journal of Clinical Investigation (2000)

Developing gene therapy for cystic fibrosis has been hindered by limited binding and endocytosis of vectors by human airway epithelia. Here we show that the apical membrane of airway epithelia express the urokinase plasminogen activator receptor (uPAR). Urokinase plasminogen activator (uPA), or a 7-residue peptide derived from this protein (u7-peptide), bound the receptor and stimulated apical endocytosis. Both ligands enhanced gene transfer by nonspecifically bound adenovirus and adeno-associated virus vectors and by a modified adenovirus vector that had been coupled to the u7-peptide. These data provide the first evidence that targeting an apical receptor can circumvent the two most important barriers to gene transfer in airway epithelia. Thus, the uPA/uPAR system may offer significant advantages for delivering genes and other pharmaceuticals to airway epithelia.
GPs' active participation will be crucial to success of CCGs, NHS Confederation says
Authors: G. Iacobucci
Journal: BMJ (2013)

The new clinical commissioning groups (CCGs) in England must build on the successes of the outgoing primary care trusts and not begin by “starting again from scratch,” says the NHS Confederation.

In a new report outlining lessons for CCGs to take forward, the confederation, the membership body for organisations that commission and provide NHS services, said that many primary care trusts made significant progress in developing effective commissioning during their 13 year lifespan and that this progress should not be overlooked in the new system.1

CCGs assumed statutory responsibility for commissioning around £65bn (€76bn; $99bn) of NHS services on 1 April 2013, after the coalition government’s Health and Social Care Act 2012 abolished primary care trusts.2

Ministers and critics of the former …
Current recommendations for<i><i>Helicobacter pylori</i></i>therapies in a world of evolving resistance
Authors: Francis Mégraud
Journal: Gut Microbes (2013)

Occurrence of resistance, especially to clarithromycin, renders the standard triple therapy used to cure Helicobacter pylori infection ineffective. This review presents the bacteriological and pharmacological basis for H. pylori therapy and the current recommendations. The third-line treatment must be based on clarithromycin susceptibility testing. If the bacteria are still susceptible, failure may come from problems of compliance, hyperacidity or high bacterial load which can be overcome. If the bacteria are resistant, different regimens must be considered, including bismuth and non-bismuth-based quadruple therapies (sequential or concomitant), as well as triple therapies where amoxicillin is administered several times a day to obtain an optimal concentration at the gastric mucosal level. The treatments are becoming more and more complex and ecologically unsatisfactory, waiting for new agents or vaccines.
What's in a brand name?
Authors: J K Aronson
Journal: BMJ (1994)

When doctors prescribe drugs by their brand names they can confidently expect that their patients will be given particular compounds by the pharmacist.For example, if they prescribe Brufen they can be confident that the pharmacist will dispense a formulation that contains ibuprofen.When patients buy drugs over the counter, however, matters may be more complicated.For example, if they buy tablets with the name Anadin on the box they may be buying a formulation that contains aspirin and caffeine; aspirin, caffeine, and quinine; aspirin, caffeine, and paracetamol; paracetamol alone; or even ibuprofen alone.Of course, these different formulations may have slightly different names, such as Anadin Extra for aspirin plus caffeine plus paracetamol --and Anadin Paracetamol for paracetamol alone; but it takes a high degree of awareness to realise, for example, that one of these contains aspirin while the other does not.In another example Aspro Paraclear contains paracetamol and not aspirin whereas Aspro Clear contains aspirin and not paracetamol.There are several similar examples of brand name drugs that are available over the counter under the same or closely similar names but that contain different drugs or combinations of drugs.The table lists these- both formulations for oral use and formulations for topical use-culled from an issue of Chemist and Dnuggist.1This list is by no means comprehensive.For example, I have omitted formulations for which differences are limited to what might be regarded as inactive excipients, such as sodium citrate in efferves- cent formulations.I have also omitted examples in
THU0471 Myeloid Deletion of SIRT1 Suppresses Collagen-Induced Arthritis in Mice by Modulating Dendritic Cell Function
Authors: H.-O. Kim, Y.S. Suh, I.-I. Lee, H.S. Lim, Y.-H. Cheon, W.-H. Yoo, W.-S. Lee, B.-H. Park
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Objectives</h3> The type III histone deacetylase SIRT1 is a critical molecule in the modulation of immune and inflammatory response through the deacetylation of various histones and non-histone proteins. However, there are limited and controversial data regarding the roles of SIRT1 in rheumatoid arthritis (RA) and its role in dendritic cells (DCs) remains unknown. Thus, this study sought to assess the role of SIRT1 in collagen-induced arthritis (CIA) using a myeloid cell-specific SIRT1 knockout (mSIRT1 KO) mouse. <h3>Methods</h3> mSIRT1 KO mice were generated using the loxP/Cre recombinase system. CIA was induced in mSIRT1 KO mice and age-matched littermate loxP control mice. Arthritis severity was assessed by clinical, radiological, and pathological scoring. The levels of various cytokines in the joints, serum, lymph nodes were determined by quantitative polymerase chain reaction and ELISA. T cells and DCs were quantified using flow-cytometry and in vitro T cell cytokines and DCs markers were also measured. <h3>Results</h3> The mSIRT1 KO mice showed significantly lower arthritis severity and joint destruction compared with control mice. The expression of inflammatory cytokines, MMPs, and ROR-γT was also reduced in mSIRT1 KO mice. These effects were paralleled by reduction of Th1, Th17, CD69-positive T cells, CD80, and CD86 positive DCs in mSIRT1 KO mice. In addition, in vitro studies showed that interferon-γ and IL-17 production by T cells and the maturation of DCs were significantly decreased in mSIRT1 KO mice. <h3>Conclusions</h3> Unlike passive K/BxN serum transfer arthritis, myeloid cell-specific deletion of SIRT1 was associated with lower arthritis severity in CIA by modulating DCs maturation and Th1 and Th17 responses. The data suggest that SIRT1 plays a complex role in RA and careful investigation of cell-specific effects is necessary to delineate possible therapeutic uses of agents targeting SIRT1. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4188
Erratum to “New Insights and Unresolved Issues Regarding Insertional Mutagenesis in X-linked SCID Gene Therapy”
Authors: Karin Pike-Overzet, Mirjam Van Der Burg, Gerard Wagemaker, Jacques JM Van Dongen, Frank JT Staal
Journal: Molecular Therapy (2007)

Molecular Therapy (2007) advance online publication 28 August 2007; doi:10.1038/sj.mt.6300297 In this article, on p. 5, the first paragraph in the left column, the sentence “In addition, it was not reported whether the mutation in the IL2RG gene might be caused, for instance, by errors in lentiviral reverse transcription” should have read “In addition, it was not reported whether the IL2RG gene might be mutated, for instance, due to errors in lentiviral reverse transcription.” In addition, two references were omitted: Deichmann, A et al. (2007). Vector integration is non-random, clustered and influences the in vivo fate of lymphopoiesis in SCID-X1 gene therapy. J Clin Invest (in press). Schwarzwaelder, K et al. (2007). Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo. J Clin Invest (in press). These, along with ref. 52, are the papers referred to in the sentence on p. 5, right column (“three back-to-back reports in the The Journal of Clinical Investigation, each report dealing with a different SCID gene therapy trial”). Consequently, references 53–56 should have been numbered 55–58. Upon publication of this article, Dr. Cavazzana-Calvo, with whom the authors consulted during the preparation of the article, provided the following additional information: the exact nature of the integration sites in the third patient who developed a T-ALL like disease in the SCID-X1 trial needs to be further investigated, but likely is a known T-ALL oncogene.
Surgical Treatment of Ventricular Aneurysms
Authors: W. Gerald Austen
Journal: New England Journal of Medicine (1973)

The surgical treatment of ventricular myocardial aneurysms has been somewhat controversial. Most clinicians now agree that refractory congestive heart failure or arterial embolization from clot in the aneurysm constitutes an adequate indication for operation. Congestive heart failure has been the commonest symptom and has been shown to be due to paradoxical filling of the poorly functioning aneurysmal area or poor myocardial function secondary to myocardial dilatation (or both) combined, in some cases, with damage of the remaining myocardium.1 , 2 Usually, the aneurysm is apical or anterior (or both) and involves occlusion or severe narrowing of the anterior descending coronary artery. Posterior . . .