tbuckley/cabot-search huggingface dataset:
S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy
Authors: Catherine Espeillac, Claudia Mitchell, Séverine Celton-Morizur, Céline Chauvin, Vonda Koka, Cynthia Gillet, Jeffrey H. Albrecht, Chantal Desdouets, Mario Pende
Journal: Journal of Clinical Investigation (2011)

Rapamycin is an antibiotic inhibiting eukaryotic cell growth and proliferation by acting on target of rapamycin (TOR) kinase. Mammalian TOR (mTOR) is thought to work through 2 independent complexes to regulate cell size and cell replication, and these 2 complexes show differential sensitivity to rapamycin. Here we combine functional genetics and pharmacological treatments to analyze rapamycin-sensitive mTOR substrates that are involved in cell proliferation and tissue regeneration after partial hepatectomy in mice. After hepatectomy, hepatocytes proliferated rapidly, correlating with increased S6 kinase phosphorylation, while treatment with rapamycin derivatives impaired regeneration and blocked S6 kinase activation. In addition, genetic deletion of S6 kinase 1 (S6K1) caused a delay in S phase entry in hepatocytes after hepatectomy. The proliferative defect of S6K1-deficient hepatocytes was cell autonomous, as it was also observed in primary cultures and hepatic overexpression of S6K1-rescued proliferation. We found that S6K1 controlled steady-state levels of cyclin D1 (Ccnd1) mRNA in liver, and cyclin D1 expression was required to promote hepatocyte cell cycle. Notably, in vivo overexpression of cyclin D1 was sufficient to restore the proliferative capacity of S6K-null livers. The identification of an S6K1-dependent mechanism participating in cell proliferation in vivo may be relevant for cancer cells displaying high mTOR complex 1 activity and cyclin D1 accumulation.
Loss of Histone H4K20 Trimethylation Occurs in Preneoplasia and Influences Prognosis of Non–Small Cell Lung Cancer
Authors: Arnaud Van Den Broeck, Elisabeth Brambilla, Denis Moro-Sibilot, Sylvie Lantuejoul, Christian Brambilla, Beatrice Eymin, Saadi Khochbin, Sylvie Gazzeri
Journal: Clinical Cancer Research (2008)

Epigenetic modifications of histone have crucial roles in the control of gene activity, nuclear architecture, and genomic stability. In this respect, they may contribute to the development and progression of cancer. We investigated whether epigenetic changes of histone H4 are involved in lung carcinogenesis.Epigenetic modifications of histone H4 were studied by immunohistochemistry in normal lung and 157 lung carcinoma using antibodies specifically recognizing the acetylated (Ac) lysines 5 (K5), K8, K12, K16, and trimethylated (me3) K20 residues of histone H4. Western blotting was used to validate the immunohistochemistry results. H4K20me3 was also studied in 17 preneoplastic lesions. Expression of the Suv4-20h1/2 trimethyltransferases was analyzed by quantitative reverse transcription-PCR in a subset of tumor samples.As compared with normal lung, cancer cells displayed an aberrant pattern of histone H4 modifications with hyperacetylation of H4K5/H4K8, hypoacetylation of H4K12/H4K16, and loss of H4K20 trimethylation. Alteration of H4K20 trimethylation was frequent in squamous cell carcinoma (67%) and was observed in early precursors lesions in which the level of H4K20me3 staining strongly decreased with disease progression. In adenocarcinoma, the down-regulation of H4K20me3 was less frequent (28%) but allowed the identification of a subgroup of stage I adenocarcinoma patients with reduced survival (P = 0.007). Loss of H4K20 trimethylation was associated with decreased expression of Suv4-20h2, a specific H4K20 trimethyltransferase involved in telomere length maintenance.Our findings indicate an important role of histone H4 modifications in bronchial carcinogenesis and highlight H4K20me3 as a candidate biomarker for early detection of and therapeutic approaches to lung cancer.
Pendred's Syndrome in Two Families Living in Endemic Goitre Area
Authors: S. Najjar
Journal: BMJ (1963)

other two groups.These epidemiological findings indicate a definite relationship between the nephrotic syndrome in Nigerian children and infection with P. malariae.The clinical, biochemical, and histological features are similar to those classically described in childhood, with two important differences: (1) the age at onset is much later than in Europe or America, and (2) the condition is closely associated with infection by P. malariae.We have been unable to confirm the dramatic results with antimalarial treatment reported by others.The possible mechanisms of production of " malarial nephrosis" are discussed.
Comparison of different antinucleic acid antibody spectrotypes in spontaneous, induced, and murine lupus.
Authors: M Fischbach, J Rabbie, N Talal
Journal: Journal of Clinical Investigation (1981)

Sera from patients with systemic lupus erythematosus and from mice spontaneously developing lupus were subjected to isoelectric focusing by a microsucrose gradient method. The spectrotypes of human antibodies to native DNA, denatured DNA, and polyriboadenylic acid (poly A) were compared. Antibodies to native DNA and denatured DNA focused into two regions whose boundaries were pH 5.0-7.0 and pH 8.5-10.0. Antinative DNA antibodies were more homogeneous than antidenatured DNA antibodies. Anti-DNA antibodies in cryoglobulins showed more restriction than those present in serum. There was no relationship between spectrotype and pattern of disease expression. Murine antibodies to native DNA were more heterogeneous than human anti-DNA antibodies. The spectrotypes of antidenatured DNA antibodies from patients with systemic lupus erythematosus or drug induced lupus, or from an immunized rabbit, were similar. Likewise, antibodies to poly A were similar in both human and murine lupus. In contrast to anti-DNA, antibodies to poly A were restricted and focused only in the alkaline range (pH 9.5-10.0). The spectrotype of antipoly A antibodies induced by lipopolysaccharide were comparable but had an additional small band at pH 6.2. Our results suggest unique antibody spectrotypes with varying degrees of restriction for different nucleic acid antigens. Furthermore, spontaneous and induced autoantibodies have similar spectrotypes. Thus, the B cell clones producing antinucleic acid antibodies may be similar whether they are activated spontaneously, following immunization, or as a consequence of polyclonal stimulation.
Toxic Psychosis Due to Diphenhydramine Hydrochloride
Authors: Samuel A. Nigro
Journal: JAMA (1968)

A patient who had taken an overdose of diphenhydramine hydrochloride showed schizophrenia-like behavior initially which changed to include features of an acute brain syndrome. Throughout, signs of cholinergic hypofunction were evident. The mental state reverted to normal 29 hours after the ingestion.
Gastric Ulceration Occurring during Indomethacin Therapy
Authors: R. T. Taylor, E. C. Huskisson, G. H. Whitehouse, F. D. Hart, D. H. Trapnell
Journal: BMJ (1968)

Dyspeptic symptoms, gastrointestinal bleeding, or the development of anaemia without dyspepsia in patients treated with indomethacin may be manifestations of peptic ulceration. Such manifestations occur with suppositories as well as with capsules. The ulcers in the present series tended to be prepyloric, and often aroused the suspicion of malignancy. Symptoms were promptly relieved and radiological healing occurred rapidly after withdrawal of the drug.
Targeting hematologic malignancies with oncolytic vaccinia virus constructs
Authors: Nanhai Chen, Mehmet Kilinc, Qian Zhang, Jason Aguilar, Desislava Tsoneva, Maysam Pessian, Boris Minev, Aladar Szalay
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Oncolytic viruses are a promising approach for cancer therapy. Recent clinical trials proved the safety and anti-tumor activity of several oncolytic viruses in solid tumors. However, very little is known about the potential of the oncolytic viruses to target hematologic
Food incentives to improve completion of tuberculosis treatment: randomised controlled trial in Dili, Timor-Leste
Authors: N. Martins, P. Morris, P. M Kelly
Journal: BMJ (2009)

The effects of asthma on pregnancy outcomes differ between studies. A recent review indicates that the conflicting results are related to study design, where larger database studies have reported increased risks, and smaller clinical prospective cohort studies have not found significantly increased risks. We study the effect of asthma within a large study of air pollution and preterm birth; is there an increase in preterm birth and how common are exacerbations in pregnancy resulting in outpatient hospital visits? Our study cohort from Stockholm, Sweden, is constructed by matching live births 1998-2006 from the Medical Birth Registry with information on the mother from the Patient Registry (1987-2010 for hospital admissions and 2001-2010 for outpatient hospital visits) and information from the drug register (July 2006 -2011). We define all mothers who had at least one hospital visit for asthma or had asthma medication as having asthma. We used logistic regression to assess the relation between asthma and preterm birth. We adjusted the model for education, previous preterm birth, origin, parity, date of conception and maternal age. The prevalence of preterm birth was 5.4 % among mothers with asthma (n=13 261) and 4.4 % in the rest of the population (n= 111 931). The odds ratio for giving birth preterm was 1.27 (p &lt; 0.01) for women with asthma compared to non-asthmatic mothers. 1.9 % of the asthmatic mothers had a hospital contact for asthma during pregnancy, and 8.4 % of them delivered preterm. Asthma is associated with an increased risk of preterm birth, particularly in women with exacerbations of the asthma during pregnancy.
Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives
Authors: John Farrell, Maike Lichtenfels, Andrew Sullivan, Emma C. Elliott, Ana Alfirevic, Andrew V. Stachulski, Munir Pirmohamed, Dean J. Naisbitt, B. Kevin Park
Journal: Journal of Allergy and Clinical Immunology (2013)
Support Lags for Research on Steroid Effects
Authors: Virginia S. Cowart
Journal: JAMA (1989)

EFFORTS TO GAIN international agreement on drug testing in sports continue, with the latest developments emerging from a world congress in the Soviet Union.  A charter covering areas of international agreement on drug testing and sanctions was developed at a 1987 meeting in Ottawa, Canada. That charter, which has nine annexes and covers what is currently believed by its authors to be right and wrong in sports in this regard, was approved by the International Olympic Committee in Seoul, South Korea, in September 1988.  Next: Norway  The goal of the latest meeting, in Moscow, has been to develop specific points on out-of-competition testing, education, and the rights and responsibilities of athletes and other members of the sports community. Agreement on additional specifics is expected to be the focus of the next world congress, set for 1991 in Oslo, Norway.  Andrew Pipe, MD, who chairs the National Advisory Committee on Drug
Abstract 3163: Gender-Specific Reference Values for Left Ventricular Anatomy and Systolic Function Using Modern Cardiovascular Magnetic Resonance Methods in a Longitudinally Followed Normotensive Population: The Framingham Heart Study
Authors: Carol J Salton, Philimon Gona, Michael L Chuang, Susan B Yeon, Elizabeth A Goddu, Martin G Larson, Susan J Blease, Daniel Levy, Christopher J O'Donnell, Warren J Manning
Journal: Circulation (2006)
Comparison of proprietary elemental and whole-protein diets in unconscious patients with head injury.
Authors: D C Jones, A J Rich, P D Wright, I D Johnston
Journal: BMJ (1980)

Forty men who had sustained head injury were randomly assigned to one of five groups to receive 0.2 g nitrogen/kg body weight/day as either an elemental or a whole-protein diet. Three proprietary elemental and two whole-protein diets were compared. The mean daily nitrogen intake was below 0.2 g/kg in all groups, and was significantly lower in the groups receiving elemental compared with whole-protein diets. Energy intake was significantly different only between one group receiving an elemental and one receiving a whole-protein diet. Mean daily urinary nitrogen excretion was significantly lower in the groups receiving elemental diets, and mean daily nitrogen balance was negative in all groups except one receiving a whole-protein diet. Reduced nitrogen intakes occurred particularly with the elemental diets, which often provoked reflex vomiting or gastric stasis. The need to introduce diets at reduced strength made a negative balance almost inevitable, but nutritional balance seemed to be more readily achieved with the whole-protein diets. More work is needed to assess the relative merits of these proprietary diets compared with tube feeds prepared in hospitals.
Current Practice of Biliary Surgery
Authors: Claude E. Welch
Journal: JAMA (1972)

Primarily because of his extensive personal experience, the author has developed a practical surgical approach to the diseases of the biliary tree. He has been influenced strongly by his teachers, particularly by those in the Lahey Clinic, and published reports from this group are cited frequently in the text. Discussion of biliary surgery prior to the last decade has been virtually eliminated. Thus the bibliography of current literature is extensive. Nevertheless, it is regrettable that past contributions are essentially ignored; for example, there is a single reference to Courvoisier and no mention of Graham or Cole. In the reviewer's opinion, the advice on many controversial subjects is excellent. Thus the author is strongly in favor of routine cholangiography, is not impressed with preoperative manometric studies of the common duct, and has reservations about the value of sphincterotomy and choledochoduodenostomy. Indeed, it is difficult to find areas of disagreement. One example,
Endoscopic Snare Mucosectomy in the Esophagus without Any Additional Equipment: A Simple Technique for Resection of Flat Early Cancer
Authors: N. Sochendra, K. F. Binmoeller, S. Bohnacker, U. Seitz, B. Brand, F. Thonke, G. Gurakuqi
Journal: Endoscopy (1997)

Background and Study Aims: Endoscopic mucosal resection of early esophageal cancer has increasingly proved to be an effective treatment modality, especially if the tumor has not invaded the muscularis mucosae. Different techniques have been introduced, using an overtube, double-channel endoscope, or suction cap. We have not found that these devices are required for snare resection in the esophagus.
534 Complement factor 5 is no genetic risk factor for the progression of liver fibrosis in chronic hepatitis C infection
Authors: J. Halangk, C. Sarrazin, G. Puhl, G. Teuber, H. Klinker, P. Buggisch, H. Hinrichsen, V. Weich, A. Bergk, B. Wiedenmann, P. Neuhaus, H. Witt, T. Berg
Journal: Journal of Hepatology (2006)
Prevalence of Consensual Male–Male Sex and Sexual Violence, and Associations with HIV in South Africa: A Population-Based Cross-Sectional Study
Authors: Kristin L. Dunkle, Rachel K. Jewkes, Daniel W. Murdock, Yandisa Sikweyiya, Robert Morrell
Journal: PLoS Medicine (2013)

Using a method that offered complete privacy to participants, Rachel Jewkes and colleagues conducted a survey among South African men about their lifetime same-sex experiences. Please see later in the article for the Editors' Summary
Changes in coronary risk factors during comprehensive five-year community programme to control cardiovascular diseases (North Karelia project).
Authors: P Puska, J Tuomilehto, J Salonen, L Neittaanmaki, J Maki, J Virtamo, A Nissinen, K Koskela, T Takalo
Journal: BMJ (1979)

A comprehensive community programme to control cardiovascular diseases (CVD) in North Karelia, Finland, was carried out during 1972-7. The central intermediate objective of the programme was to reduce the prevalence of smoking, the serum cholesterol concentration, and raised blood-pressure values among the population of the area. The effect was evaluated by examining independent representative population samples in 1972 and 1977 in both the county of North Karelia and a matched control county. Over 10 000 subjects were studied each time, the participation rate being around 90%. The decrease that occurred in the risk factors, especially in men, was in general greater in North Karelia compared with the control county. When a multiple logistic function was used for the three risk factors an overall mean net reduction of 17% among men and 12% among women was observed in the estimated risk for coronary heart disease in North Karelia. This community programme effectively reduced the levels of the three main risk factors for CVD in the population, and thus mortality and morbidity from CVD should fall. This is assessed in further studies.
Additional treatment with 2-Chloro-2-Deoxyadenosine during consolidation in children with high-risk acute myeloid leukemia does not improve survival
Authors: U Creutzig, M N Dworzak, M Zimmermann, J-P Bourquin, B Gruhn, G Fleischhack, N Graf, T Klingebiel, B Kremens, T Lehrnbecher, C von Neuhoff, A v Stackelberg, J Starý, D Reinhardt
Journal: Leukemia (2015)
Methylphenidate for Cerebral Palsy with Choreoathetosis
Authors: Willem Boogerd, Jos H. Beijnen
Journal: Annals of Internal Medicine (2000)

Letters21 March 2000Methylphenidate for Cerebral Palsy with ChoreoathetosisWillem Boogerd, MD, PhD and Jos H. Beijnen, PhDWillem Boogerd, MD, PhDSlotervaart Hospital; Amsterdam, the Netherlands 1066 EC (Boogerd)Slotervaart Hospital; Amsterdam, the Netherlands 1066 EC (Beijnen) and Jos H. Beijnen, PhDSlotervaart Hospital; Amsterdam, the Netherlands 1066 EC (Boogerd)Slotervaart Hospital; Amsterdam, the Netherlands 1066 EC (Beijnen)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-6-200003210-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We have observed an unexpected effect of methylphenidate on spasticity and dystonia. A considerable proportion of patients with cerebral palsy due to perinatal asphyxia have spasticity and extrapyramidal signs. Physical therapy and many drugs are being used to relieve symptoms but usually have no noticeable effect. A 44-year-old woman with congenital cerebral palsy who used a wheelchair because of marked spasticity of the legs and choreoathetosis of the face, trunk, and upper extremities had been given haloperidol, tiapride, clonazepam, biperiden, trihexyphenidyl, diazepam, tizanidine, and baclofen. These drugs had minor efficacy that did not outweigh the side effects. ...References1. Elia J. Drug treatment for hyperactive children. Therapeutic guidelines. Drugs. 1993;46:863-71. CrossrefMedlineGoogle Scholar2. Hungund BL, Perel JM, Hurwec MJ, Sverd J, Winsberg BG. Pharmacokinetics of methylphenidate in hyperkinetic children. Br J Clin Pharmacol. 1979;8:571-6. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Slotervaart Hospital; Amsterdam, the Netherlands 1066 EC (Boogerd)Slotervaart Hospital; Amsterdam, the Netherlands 1066 EC (Beijnen) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMethylphenidate Can Improve Chorea in NKX2.1 and ADCY5 Mutation-positive Patients-A Report of Two ChildrenEfficacy of oral pharmacological treatments in dyskinetic cerebral palsy: a systematic reviewThe Effects of Methylphenidate on the Classroom Behavior of Elementary School—Age Children With Cerebral Palsy: A Preliminary Observational AnalysisMethylphenidate fails to improve gait and muscle tone in patients with sporadic and hereditary spastic paraplegia 21 March 2000Volume 132, Issue 6Page: 510KeywordsCatecholaminesCerebral palsyChildrenDiazepamDrug therapyDystoniaIngestionMental functioningToxinsWheelchairs Issue Published: 21 March 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Interleukin-3 and interferon β cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties
Authors: Christel Buelens, Emmanuel J. Bartholomé, Zoulikha Amraoui, Michael Boutriaux, Isabelle Salmon, Kris Thielemans, Fabienne Willems, Michel Goldman
Journal: Blood (2002)
Acrodermatitis chronica atrophicans in an 11-year-old girl
Authors: R.R. MUELLEGGER, E.M. SCHLUEPEN, M.M. MILLNER, H.P. SOYER, M. VOLKENANDT, H. KERL
Journal: British Journal of Dermatology (1996)

We report a case of acrodermatitis chronica atrophicans in an 11-year-old girl living in an area endemic for Lyme borreliosis. The diagnosis was first made on the basis of clinical, histopathological and serological findings. Moreover, Borrelia burgdorferi-specific DNA was amplified from lesional skin by polymerase chain reaction. Intravenous treatment with ceftriaxone (2 g once daily) for 2 weeks was initiated. The skin changes clearly responded to the therapy, and Borrelia burgdorferi-specific gene segments were no longer detectable by polymerase chain reaction. This is the first report of molecular-proven acrodermatitis chronica atrophicans in childhood. The occurrence of this late skin manifestation of Lyme borreliosis in children is reviewed.
Lack of Association between the BIM Deletion Polymorphism and the Risk of Lung Cancer with and without EGFR Mutations
Authors: Hiromichi Ebi, Isao Oze, Takayuki Nakagawa, Hidemi Ito, Satoyo Hosono, Fumihiko Matsuda, Meiko Takahashi, Shinji Takeuchi, Yukinori Sakao, Toyoaki Hida, Anthony C. Faber, Hideo Tanaka, Yasushi Yatabe, Tetsuya Mitsudomi, Seiji Yano, Keitaro Matsuo
Journal: Journal of Thoracic Oncology (2014)
Topical treatment for human papillomavirus-associated genital warts in humans with the novel tellurium immunomodulator AS101: assessment of its safety and efficacy
Authors: M. Friedman, I. Bayer, I. Letko, R. Duvdevani, O. Zavaro-Levy, B. Ron, M. Albeck, B. Sredni
Journal: British Journal of Dermatology (2008)

Various methods are currently used for the treatment of anogenital warts. However, a complete cure is unlikely, and the rate of recurrence is high.The purpose of this open-label, multicentre trial was to evaluate the safety and clinical efficacy of a new treatment using the immunomodulator ammonium trichloro (dioxoethylene-O,O') tellurate (AS101; Biomas Ltd, Kefar Saba, Israel) 15% w/w cream to clear vulval/perianal condylomata acuminata.Study participants comprised 48 women and 26 men, age range 18-62 years. Of the 48 woman, 44 were diagnosed with vulval condylomata and four with perianal condylomata. All 26 men were diagnosed with perianal condylomata. All the patients in the study received AS101 15% w/w cream twice a day. Maximal treatment duration was 16 weeks. To evaluate the safety and clinical efficacy, patients were examined and lesional areas photographed on a biweekly basis.By the end of the treatment, 56 of 74 (76%) patients were considered completely cleared. Complete cure was achieved in 35 of 44 (80%) patients with vulval condylomata and in 21 of 30 (70%) patients with perianal condylomata. No scarring of treated areas was observed. Complete cure was achieved within a time range of 10-109 days. The most frequent side-effects observed were mild-to-moderate itching, soreness, burning and erythema. In post-treatment follow up of up to 6 months, disease recurrence was observed in two patients (4%), at 105 and 144 days following completion of treatment.AS101 15% w/w cream is an effective and safe, self-administered therapy used for the treatment of external vulval and perianal warts. The cream is applied topically twice daily for up to 16 weeks. A very low recurrence rate was reported.