tbuckley/cabot-search huggingface dataset:
MULTIPLE BASAL-CELL EPITHELIOMATA FOLLOWING RADIOTHERAPY OF THE SPINE
Authors: I. SARKANY, R. B. FOUNTAIN, C. D. EVANS, R. MORRISON, L. SZUR
Journal: British Journal of Dermatology (1968)

Journal Article MULTIPLE BASAL‐CELL EPITHELIOMATA FOLLOWING RADIOTHERAPY OF THE SPINE Get access I. SARKANY, I. SARKANY Royal Free Hospital, London, W.C.I (Dr. Sarkany and Dr. Fountain) United Bristol Hospitals (Dr. Evans) Search for other works by this author on: Oxford Academic Google Scholar R. B. FOUNTAIN, R. B. FOUNTAIN Royal Free Hospital, London, W.C.I (Dr. Sarkany and Dr. Fountain) United Bristol Hospitals (Dr. Evans) Search for other works by this author on: Oxford Academic Google Scholar C. D. EVANS, C. D. EVANS Royal Free Hospital, London, W.C.I (Dr. Sarkany and Dr. Fountain) United Bristol Hospitals (Dr. Evans) Search for other works by this author on: Oxford Academic Google Scholar R. MORRISON, R. MORRISON Hammersmith Hospital and St. John's Hospital for Diseases of the Skin, London (Dr. Morrison and Dr. Szur) Search for other works by this author on: Oxford Academic Google Scholar L. SZUR L. SZUR Hammersmith Hospital and St. John's Hospital for Diseases of the Skin, London (Dr. Morrison and Dr. Szur) Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 2, 1 February 1968, Pages 90–96, https://doi.org/10.1111/j.1365-2133.1968.tb12267.x Published: 01 February 1968 Article history Accepted: 22 July 1967 Published: 01 February 1968
Abstract 3214: C-seco taxanes with 7, 9-linkages exhibit better activity in drug-resistant tumor cells
Authors: Yong Tang, Pei Cai, Javier Rodríguez-Salarisch, J. Fernando Díaz, Weishuo Fang
Journal: Cancer Research (2014)

Abstract Taxanes are a group of very successful MT stabilizing agents in cancer chemotherapy, although they suffer from tumor drug resistance, which compromises clinical efficacy. Many efforts were made in our labs to the structural modification of paclitaxel to improve efficacy against tumor drug resistance mediated by multiple mechanisms, with the emphasis on two clinically relevant ones: P-glycoprotein (Pgp) and β-III tubulin overexpression. While Pgp mediated multidrug resistance has been extensively explored and applied to the drug discovery projects, β-III tubulin overexpression related drug resistance was much less explored. The β-III tubulin isotype was found to play an important role in conferring resistance to MT stabilizing agents only in recent decade. It has also been identified as a survival factor in several types of cancers, thus conferring resistance to various anticancer agents, such as MT destabilizing agents and DNA interacting agents. We have found some high affinity taxanes (e.g. LX2-32C, Yg-3-46a) exhibited their activity toward Pgp efflux pump and also β-III tubulin mediated drug resistance. However, they did not show greater specificity for the β-III tubulin isotype. Based on a C-seco taxane IDN5390 which was reported to be more selectively interacted with β-III tubulin than paclitaxel, we have succeeded in the design and synthesis of 7,9-O-linked C-seco taxanes with different linkages. Some of them exhibited better activity than IDN5390, and the activities were found sensitive to the structural changes of the linkers. Citation Format: Yong Tang, Pei Cai, Javier Rodríguez-Salarisch, J. Fernando Díaz, Weishuo Fang. C-seco taxanes with 7, 9-linkages exhibit better activity in drug-resistant tumor cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3214. doi:10.1158/1538-7445.AM2014-3214
Prevention of recurrent variceal bleeding in alcoholic cirrhotic patients: prospective controlled trial of propranolol and sclerotherapy
Authors: Valérie Rossi, Paul Calès, Pascal Burtin, Jacky Charneau, Bruno Person, Pascale Pujol, Stéphanie Valentin, Nicolas D'Aubigny, Francis Joubaud, Jean Boyer
Journal: Journal of Hepatology (1991)
Acquired congenital heart block. Pattern of maternal antibody response to biochemically defined antigens of the SSA/Ro-SSB/La system in neonatal lupus.
Authors: J P Buyon, E Ben-Chetrit, S Karp, R A Roubey, L Pompeo, W H Reeves, E M Tan, R Winchester
Journal: Journal of Clinical Investigation (1989)

The molecular basis of autoantibody reactivity with components of the SSA/Ro-SSB/La particle exhibited by sera of mothers of infants with severe and permanent manifestations of neonatal lupus (NLE) was investigated using immunoblotting and immunoprecipitation. The characteristics of NLE that were studied included congenital complete heart block (CCHB), second degree heart block, and hepatic fibrosis. Antibodies specific for one or more components of the SSA/Ro-SSB/La particle were found in sera from all 20 mothers of permanently affected infants. However, no antibody specific for a single peptide of this particle was common to all sera. Using tissue extracts from a human cell substrate, 80% of these sera had antibodies to one or more components of the SSA/Ro particle demonstrable by immunoblotting. The predominant antibody response in the NLE group was to the newly recognized 52-kD SSA/Ro peptide component. In contrast, antibodies to the 60-kD SSA/Ro component although present, were the least represented and not significantly increased in frequency among mothers of these infants, compared with a group of 31 mothers with autoimmune diseases such as systemic lupus erythromatosus (SLE) but who had healthy offspring. Antibodies directed to the 48-kD SSB/La antigen were demonstrated in 90% of the NLE mothers often accompanying antibodies against the 52-kD SSA/Ro component. The combination of antibodies to 48- and 52-kD structures was significantly increased in the NLE group, with an odds ratio of 35. The type of cell or tissue substrate was shown to influence detectability of antibodies. The 52-kD SSA/Ro peptide and the 48-kD SSB/La peptide were abundant in cardiac tissues from fetuses aged 18-24 wk, further supporting the possible relevance of these peptides to heart block.
Inferior and Posterior Myocardial Infarction
Authors: CHRISTIE B. HOPKINS
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 April 1982Inferior and Posterior Myocardial InfarctionCHRISTIE B. HOPKINS, M.D.CHRISTIE B. HOPKINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-4-538_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the January issue, Nesmith and coworkers (1) discussed inferior infarction associated with anterior S-T segment depression. They noted a higher in-hospital mortality but remarked on the absence of critical anterior stenosis in many patients with the anterior S-T segment abnormality. Two recent articles (2, 3) comment on similar ECG abnormalities associated with acute inferior myocardial infarction. Goldberg and colleagues (3) showed the presence of significant left ventricular posterolateral wall dysfunction when S-T segment depression occurred in the anterior precordial leads.I believe the explanation for the ECG abnormality is as follows: Leads VI and V2 "see"...References1. NESMITHMARPOLERAHALHOMANSTEWARTSNIDERMAN JDDJSA. Clinical outcomes after inferior myocardial infarction. Ann Intern Med. 1982;96:22-6. LinkGoogle Scholar2. SALCEDOBAIRDCHAMBERSBEANLANDS JMRD. Significance of reciprocal S-T segment depression in anterior precordial leads in acute inferior myocardial infarction: concomitant left anterior descending coronary artery disease. Am J Cardiol. 1981;48:1103-8. CrossrefMedlineGoogle Scholar3. GOLDBERGBORERJACOBSTEINKLUGER SCHEIDTALONSO HJJSD. Anterior S-T segment depression in acute inferior myocardial infarction: indicator of posterolateral infarction. Am J Cardiol. 1981;48:1009-15. CrossrefMedlineGoogle Scholar4. GRANTESTES HE. Spatial vector electrocardiography. Philadelphia: The Blakiston Company; 1951:104. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHRISTIE B. HOPKINS, M.D.Affiliations: Dorn Veterans' Hospital Columbia, SC 29201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1982Volume 96, Issue 4Page: 538-538KeywordsElectrocardiography ePublished: 12 March 2020 Issue Published: 1 April 1982 PDF downloadLoading ...
Pyoderma vegetans and ulcerative colitis
Authors: L. Bianchi, A.M. Carrozzo, A. Orlandi, E. Campione, J.H. Hagman, S. Chimenti
Journal: British Journal of Dermatology (2001)

Journal Article Pyoderma vegetans and ulcerative colitis Get access L. Bianchi, L. Bianchi Institute of Dermatology and Institute of Anatomical Pathology, University of Rome 'Tor Vergata', Ospedale S.Eugenio, Piazzale dell'Umanesimo 10, 00144 Rome, Italy Luca Bianchi, Institute of Dermatology, University of Rome 'Tor Vergata', Ospedale S. Eugenio, Piazzale dell'Umanesimo 10, 00144 Rome, Italy. E‐mail: Luca.Bianchi@uniroma2.it Search for other works by this author on: Oxford Academic Google Scholar A.M. Carrozzo, A.M. Carrozzo Institute of Dermatology and Institute of Anatomical Pathology, University of Rome 'Tor Vergata', Ospedale S.Eugenio, Piazzale dell'Umanesimo 10, 00144 Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar A. Orlandi, A. Orlandi Institute of Dermatology and Institute of Anatomical Pathology, University of Rome 'Tor Vergata', Ospedale S.Eugenio, Piazzale dell'Umanesimo 10, 00144 Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar E. Campione, E. Campione Institute of Dermatology and Institute of Anatomical Pathology, University of Rome 'Tor Vergata', Ospedale S.Eugenio, Piazzale dell'Umanesimo 10, 00144 Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar J.H. Hagman, J.H. Hagman Institute of Dermatology and Institute of Anatomical Pathology, University of Rome 'Tor Vergata', Ospedale S.Eugenio, Piazzale dell'Umanesimo 10, 00144 Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar S. Chimenti S. Chimenti Institute of Dermatology and Institute of Anatomical Pathology, University of Rome 'Tor Vergata', Ospedale S.Eugenio, Piazzale dell'Umanesimo 10, 00144 Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 6, 1 June 2001, Pages 1224–1227, https://doi.org/10.1046/j.1365-2133.2001.04237.x Published: 01 June 2001
Coroner identifies two failings in care of woman who died after being refused an abortion
Authors: M. Houston
Journal: BMJ (2013)

At the end of the first week of the inquest into the death of Savita Halappanavar, the dentist who died from septicaemia at University Hospital Galway when 17 weeks pregnant, the coroner, Ciaran MacLoughlin, has identified two system failures during her care last October. 

The first involved the failure of medical staff to follow up the results of a full blood count that was taken on her admission on 21 October. MacLoughlin said that each clinical team in the obstetrics department had a responsibility to check blood results of patients under its care. The inquest had earlier heard from the admitting senior house officer that she did not think that it was up to her to follow up the test result. 

It later emerged that the full blood count had shown a significantly raised white cell count, but this was not noticed until two days after the patient’s admission.

The second system failure, the coroner said, was the failure of nursing staff to fully carry out four hourly measurements …
Magna Est Nicotina
Authors: J. Beddoe
Journal: BMJ (1900)

Mouse hepatic microsomal enzymes catalyzed the oxidation of o-, m-, and p-tolualdehydes, intermediate metabolites of xylene, to the corresponding toluic acids. Cofactor requirement for the catalytic activity indicates that the microsomes contain NAD- and NADPH-dependent enzymes for this reaction. GC/MS analyses of the carboxylic acids formed by incubation under oxygen-18 gas indicate that the mechanism for this oxidation is an oxygenation and a dehydrogenation for the NADPH- and NAD-dependent reaction. Vmax/Km (nmol/min/mg protein) ratios indicate that the NADPH-dependent activity is more pronounced than the NAD-dependent activity. These results suggest that the NADPH-dependent reaction is mainly responsible for the microsomal oxidation of tolualdehydes. The NADPH-dependent activity was significantly inhibited by SKF 525-A, disulfiram and menadione, inhibitors of cytochrome P450 (P450), suggesting the involvement of P450 in the reaction. In a reconstituted system, P450 MUT-2 (CYP2C29) purified from mouse hepatic microsomes catalyzed the oxidation of o-, m-, and p-tolualdehydes to the carboxylic acids, and the specific activities (nmol/min/nmol P450) were 1.44, 2.81, and 2.32, respectively. Rabbit antibody raised against P450 MUT-2 significantly inhibited the NADPH-dependent oxidation of tolualdehydes to toluic acids by 88% (o-), 63% (m-), and 62% (p-) using mouse hepatic microsomes. The present study demonstrated that a mouse hepatic microsomal aldehyde oxygenase, P450 MUT-2, catalyzed the most of oxidative activity of tolualdehydes to toluic acids in the microsomes.
Real-Time Assessment of Tissue Hypoxia <i>In Vivo</i> with Combined Photoacoustics and High-Frequency Ultrasound
Authors: Marco Gerling, Ying Zhao, Salvatore Nania, K. Jessica Norberg, Caroline S. Verbeke, Benjamin Englert, Raoul V. Kuiper, Åsa Bergström, Moustapha Hassan, Albrecht Neesse, J. Matthias Löhr, Rainer L. Heuchel
Journal: Theranostics (2014)

In preclinical cancer studies, non-invasive functional imaging has become an important tool to assess tumor development and therapeutic effects. Tumor hypoxia is closely associated with tumor aggressiveness and is therefore a key parameter to be monitored. Recently, photoacoustic (PA) imaging with inherently co-registered high-frequency ultrasound (US) has reached preclinical applicability, allowing parallel collection of anatomical and functional information. Dual-wavelength PA imaging can be used to quantify tissue oxygen saturation based on the absorbance spectrum differences between hemoglobin and deoxyhemoglobin.A new bi-modal PA/US system for small animal imaging was employed to test feasibility and reliability of dual-wavelength PA for measuring relative tissue oxygenation. Murine models of pancreatic and colon cancer were imaged, and differences in tissue oxygenation were compared to immunohistochemistry for hypoxia in the corresponding tissue regions.Functional studies proved feasibility and reliability of oxygenation detection in murine tissue in vivo. Tumor models exhibited different levels of hypoxia in localized regions, which positively correlated with immunohistochemical staining for hypoxia. Contrast-enhanced imaging yielded complementary information on tissue perfusion using the same system.Bimodal PA/US imaging can be utilized to reliably detect hypoxic tumor regions in murine tumor models, thus providing the possibility to collect anatomical and functional information on tumor growth and treatment response live in longitudinal preclinical studies.
Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages.
Authors: G J Prud'homme, A Fuks, E Colle, T A Seemayer, R D Guttmann
Journal: The Journal of Experimental Medicine (1984)

Spleen cells of diabetes-prone BB Wistar rats were found to generate excessively low proliferative responses, and interleukin 2 (IL-2) levels in response to T-dependent mitogens. This abnormality was not due solely to abnormal T cell numbers since: (a) addition of BB spleen cells of BB splenic macrophages to normal major histocompatibility complex (MHC)-matched Wistar Furth (WF) spleen cells resulted in severe suppression of concanavalin A (Con A)-, phytohemagglutinin (PHA)-, and pokeweed mitogen (PWM)-mediated proliferation, and IL-2 production; (b) macrophage depletion from BB spleen cells, but not B cell or T cell depletion, removed completely the suppressive effects of BB cells on WF cells; (c) macrophage depletion greatly enhanced the response of BB lymphocytes to T-dependent mitogens. Although suppressor macrophages could also be found in the spleen of WF control rats they were present in much smaller numbers than in the spleen of BB rats. The suppressive effect of BB macrophages was partially reduced by addition of the prostaglandin synthetase inhibitor indomethacin to cultures. Furthermore, indomethacin (but not catalase or PMA) considerably augmented IL-2 secretion of Con A-stimulated BB spleen cells, but had little effect on WF spleen cells. In contrast, prostaglandins E1 and E2 (PGE1 and PGE2) suppressed IL-2 production. While IL-2 secretion was severely depressed in BB rats unstimulated and lipopolysaccharide (LPS)-stimulated IL-1 secretion by splenic macrophages was normal. BB macrophages did not inactivate IL-2. Low IL-2 production and macrophage-mediated suppression were features of all BB rats tested.
Acrodermatitis chronica atrophicans affecting all four limbs in an 11-year-old girl
Authors: I. Brzonova, A. Wollenberg, J.C. Prinz
Journal: British Journal of Dermatology (2002)

Summary Borrelia burgdorferi is a major cause of morbidity in wooded area in western Europe and the eastern seaboard of the U.S.A. Diagnosis of late stage infection and associated disorders may be difficult and often requires an array of different diagnostic procedures. Here we report an 11‐year‐old girl with acrodermatitis chronica atrophicans affecting all four limbs and parts of the trunk. The diagnosis was made on the basis of clinical appearance, serological and histopathological findings, and the lesional detection of B. burgdorferi‐specific gene segments by polymerase chain reaction. This very unusual, severe case illustrates that despite being a late manifestation of tick‐borne B.burgdorferi infection, usually occurring in adults, acrodermatitis chronica atrophicans may already appear at a young age and may be characterized by extensive skin involvement.
Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adult patients with eosinophilic granuloma.
Authors: S M Aguayo, T E King, J A Waldron, K M Sherritt, M A Kane, Y E Miller
Journal: Journal of Clinical Investigation (1990)

Cigarette smoking is associated with hyperplasia of pulmonary neuroendocrine cells and variably increased levels of bombesin-like peptides in the lower respiratory tract. Because the neuropeptide bombesin is a chemoattractant for monocytes and a mitogen for 3T3 fibroblasts, we hypothesized that an excess of neuroendocrine cells and bombesin-like peptides could contribute to lung inflammation and fibrosis in certain cigarette smokers. Eosinophilic granuloma is a fibrotic lung disease of unknown etiology that in adults occurs almost invariably in cigarette smokers. We quantitated neuroendocrine cells with bombesin-like immunoreactivity in open lung biopsies from patients with eosinophilic granuloma (n = 6) and compared these with cigarette smokers (n = 6) who underwent lung resection for reasons other than primary lung disease. In addition, we compared them with patients with idiopathic pulmonary fibrosis (n = 8), a disease not associated with cigarette smoking. Finally, we also examined the mitogenic effect of bombesin on cultured human adult lung fibroblasts. The patients with eosinophilic granuloma exhibited a 10-fold increase in neuroendocrine cells with bombesin-like immunoreactivity compared to both smokers (P = 0.005) and patients with idiopathic pulmonary fibrosis (P = 0.005). In addition, bombesin produced a significant mitogenic effect on cultured human adult lung fibroblasts at concentrations of 1 nM and above. We conclude that increased numbers of pulmonary neuroendocrine cells with bombesin-like immunoreactivity are commonly found in patients with eosinophilic granuloma and, since bombesin-like peptides are chemotactic for monocytes and mitogenic for human lung fibroblasts, we speculate that neuroendocrine cell hyperplasia may be important in the pathogenesis of eosinophilic granuloma in adult cigarette smokers.
Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase
Authors: Xue Zhou, Hong Sun, Haobin Chen, Jiri Zavadil, Thomas Kluz, Adriana Arita, Max Costa
Journal: Cancer Research (2010)

Histone H3 lysine 4 (H3K4) trimethylation (H3K4me3) at the promoter region of genes has been linked to transcriptional activation. In the present study, we found that hypoxia (1% oxygen) increased H3K4me3 in both normal human bronchial epithelial Beas-2B cells and human lung carcinoma A549 cells. The increase of H3K4me3 from hypoxia was likely caused by the inhibition of H3K4 demethylating activity, as hypoxia still increased H3K4me3 in methionine-deficient medium. Furthermore, an in vitro histone demethylation assay showed that 1% oxygen decreased the activity of H3K4 demethylases in Beas-2B nuclear extracts because ambient oxygen tensions were required for the demethylation reaction to proceed. Hypoxia only minimally increased H3K4me3 in the BEAS-2B cells with knockdown of JARID1A, which is the major histone H3K4 demethylase in this cell line. However, the mRNA and protein levels of JARID1A were not affected by hypoxia. GeneChip and pathway analysis in JARID1A knockdown Beas-2B cells revealed that JARID1A regulates the expression of hundreds of genes involved in different cellular functions, including tumorigenesis. Knocking down of JARID1A increased H3K4me3 at the promoters of HMOX1 and DAF genes. Thus, these results indicate that hypoxia might target JARID1A activity, which in turn increases H3K4me3 at both the global and gene-specific levels, leading to the altered programs of gene expression and tumor progression.
Effect of Puberty on Insulinlike Growth Factor I and HbA1 in Type I Diabetes
Authors: Douglas G Rogers, Lori D Sherman, Kenneth H Gabbay
Journal: Diabetes Care (1991)

Objective To assess the effect of puberty on the relationship between glycemic control and insulinlike growth factor I (IGF-I) levels in children with insulin-dependent (type I) diabetes mellitus. Research Design and Methods Simultaneous HbA1 and plasma IGF-I levels were determined in 71 prepubertal (Tanner stage I) and 112 pubertal (Tanner stages II-V) subjects aged 2.7–17.8 yr. Results Overall, IGF-I levels were positively correlated with both age (r = 0.31, P &amp;lt; 0.001) and Tanner stage (r = 0.32, P &amp;lt; 0.001) but only weakly associated with HbA1 values (r = −0.16, P = 0.025). A strong negative association existed between IGF-I and HbA1 levels (r = −0.45, P &amp;lt; 0.001) in the pubertal subjects, but no such association was apparent in the prepubertal subjects. Multiple regression analyses disclosed a significant independent negative association between IGF-I and HbA1 levels in the pubertal group (P &amp;lt; 0.001) but not in the prepubertal group. Conclusions Glycemic control appears to strongly influence IGF-I levels only after the onset of puberty.
Getting consent for autopsies: who should ask what, and why?
Authors: G. M Sayers, J. Mair
Journal: BMJ (2001)

In the wake of the Alder Hey scandal, our trust, along with others, has produced a new and explicit consent form for autopsies.

Forty years of custom dictates that we, as clinicians, approach relatives shortly after a patient's death in order to obtain consent for an autopsy. Our reason for the request is to ascertain definitively the cause of death, and so provide answers to diagnostic questions that we could not answer while the patient was still alive.

> Relatives are asked to consider tissues, fluids, and organs in the way that they might select football teams on a pools form 

The consent form immediately addresses this issue with a clause stating: “I understand that this examination is being carried out to verify the cause of death and study the reasons.” We make clear that, as part of this examination, small tissue samples or …