tbuckley/cabot-search huggingface dataset:
(5) Epidermodysplasia verruciformis in a brother and sister
Authors: S.C. Mayou, M. Shaw, D.H. McGibbon
Journal: British Journal of Dermatology (1985)

Journal Article (5) Epidermodysplasia verruciformis in a brother and sister Get access S.C. Mayou, S.C. Mayou St Thomas's Hospital, London Se1 Search for other works by this author on: Oxford Academic Google Scholar M. Shaw, M. Shaw St Thomas's Hospital, London Se1 Search for other works by this author on: Oxford Academic Google Scholar D.H. McGibbon D.H. McGibbon St Thomas's Hospital, London Se1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Page 50, https://doi.org/10.1111/j.1365-2133.1985.tb13020.x Published: 01 July 1985
GP with 26 years' experience is struck off for "catalogue of deficiencies"
Authors: C. Dyer
Journal: BMJ (2014)

A GP who worked in the NHS for 26 years, and for the last 11 as a partner at a GP surgery, has been struck off for deficient professional performance after the Medical Practitioners Tribunal Service concluded that he “demonstrated a catalogue of deficiencies which are potentially serious and pose a risk to patient safety.”

Sirajam Haque qualified in India in 1972, trained as a GP in Warrington in 1986, and then held junior hospital posts. He worked as a locum GP from 1990, becoming a partner at the Primrose Surgery in Keighley, West Yorkshire, in 2001. Eleven years later, in November 2012, his GP …
Imatinib and Hyperlipidemia
Authors: Michele Gottardi, Enzo Manzato, Filippo Gherlinzoni
Journal: New England Journal of Medicine (2005)

To the Editor: We report on a series of nine patients with hyperlipidemia and either chronic myeloid leukemia or the hypereosinophilic syndrome, in eight of whom plasma lipid levels normalized within one month after imatinib therapy (at a dose of 400 mg daily) was started. All nine patients had hypercholesterolemia (mean plasma total cholesterol level, 254 mg per deciliter; range, 223 to 293); four of them also had hypertriglyceridemia (mean plasma triglyceride level, 264 mg per deciliter; range, 230 to 368). Patients who had concomitant diabetes mellitus, were currently consuming alcohol, or were using oral contraception were excluded. Diet, weight, . . .
League tables for health journalists
Authors: Naomi Marks
Journal: BMJ (2005)

Health journalists have become the latest pawns in the ratings game played by the Department of Health. Their stories' influence has joined measurements of surgical outcomes and managerial effectiveness set out in tables sent to civil servants and ministers.

The DoH has revealed that since last October it has been analysing national and regional media's health coverage with the results used to “assess the impact of media stories about public health issues and the NHS.” It is part of a £200 000 six-monthly survey into public attitudes—itself part of an ongoing project that the DoH claims will help it better address issues of concern to the public.

The first, and so far only, snapshot of the research results to be …
Acquired Immunodeficiency Syndrome in Peru
Authors: GUSTAVO ROJAS
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 September 1986Acquired Immunodeficiency Syndrome in PeruGUSTAVO ROJAS, M.D., EDUARDO GOTUZZO, M.D., AUGUSTO YI, M.D., FREDERICK KOSTER, M.D.GUSTAVO ROJAS, M.D.Search for more papers by this author, EDUARDO GOTUZZO, M.D.Search for more papers by this author, AUGUSTO YI, M.D.Search for more papers by this author, FREDERICK KOSTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-3-465_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The rapidity of the international spread of the acquired immunodeficiency syndrome (AIDS) depends on the extent of travel of, and contact between, at-risk groups. In 1980, coincident with the first case of AIDS in San Francisco, 11 % of homosexual men there had antibody to the human immunodeficiency virus (HIV, formerly HTLV-III/LAV) (1). In Peru, nine cases of AIDS have been diagnosed through 1985 (2), all but one in homosexual men with a history of travel to, or residence in, an endemic city (3, 4) (one case was in a hemophiliac who received a blood transfusion in...References1. CURRAN J. The epidemiology and prevention of the acquired immunodeficiency syndrome. Ann Intern Med. 1985;103:657-62. LinkGoogle Scholar2. PATRUCCO R. Sindrome de immunodeficiencia adquirida en el Peru: estudios immunologicos. Diagnostico. 1985;16(5):122-35. Google Scholar3. BRUNET J and ANCELLE R. The international occurrence of the acquired immunodeficiency syndrome. Ann Intern Med. 1985;103:670-4. LinkGoogle Scholar4. QUINN T. Informacion actualizada sobre el sindrome de immunodeficiencia adquirida. Bol Epidemiol OPS. 1985;6:1-8. Google Scholar5. WEISS S, GOEDERT J, SARNGADHARAN M, BADNER A, GALLO R, and BLATTNER W. Screening test for HTLV-III (AIDS agent) antibody: specificity, sensitivity and applications. JAMA. 1985;253:221-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GUSTAVO ROJAS, M.D.; EDUARDO GOTUZZO, M.D.; AUGUSTO YI, M.D.; FREDERICK KOSTER, M.D.Affiliations: Instituto de Medicina Tropical "Alexander von Humboldt," Universidad Peruana Cayetano Heredia Lima 100 Peru PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDeterminants and prevalence of HIV infection in pregnant Peruvian womenHIV among gay and other men who have sex with men in Latin America and the Caribbean: a hidden epidemic?*HIV, syphilis and heterosexual bridging among Peruvian men who have sex with menGender differences in sexual practices and sexually transmitted infections among adults in Lima, Peru.Acquired Immune Deficiency Syndrome (AIDS): literature, geographical origins and global patterns 1 September 1986Volume 105, Issue 3 Page: 465-466 Keywords AIDS Blood transfusion HIV Homosexuals ePublished: 1 December 2008 Issue Published: 1 September 1986 PDF downloadLoading ...
Changes in Regional Cerebral Blood Flow and Three-Phase Bone Scan After Repeated Somatic Nerve Blocks for Sympathetically Independent Pain
Authors: Bo-Feng Lin, Chen-Hwan Cherng, Yu-Ming Fan, Chih-Shung Wong, Billy K. Huh, Chun-Chang Yeh
Journal: Clinical Nuclear Medicine (2010)

The pathophysiology of complex regional pain syndrome type 1 (CRPS 1) correlates with variances in both the peripheral and central nerve system. We attempted to explore the topographic correlation between changes in regional cerebral blood flow (rCBF) and 3-phase bone scans during treatments of a series of somatic nerve blocks.The case we present here is a 24-year-old man, who suffered CRPS 1 in his right upper extremity for 4 months, and conservative therapy proved to be ineffectual to him. As he did not respond to stellate ganglion block, the syndrome was regarded as sympathetically independent pain (SIP). However, after administering a series of brachial plexus block and local anesthetics, complete resolution of pain, and restoration of function were manifested. In addition, an increase in rCBF, evidenced by single-photon emission computed tomography (SPECT), and changes in the 3 phase bone scan before and after the nerve block appear to correlate well with the clinical improvement.The changes in rCBF seem to support the theory that the pathogenesis of CRPS is also related to the central nervous system. Multiple somatic nerve blocks (SNB) not only improved physical function but also reversed the CRPS symptoms, for which we presume that reduced nociceptive input signals led to cortical reorganization.
Amikacin treatment for multidrug resistant tuberculosis: how much monitoring is required?
Authors: Veronica Melchionda, Harry Wyatt, Santino Capocci, Raul Garcia Medina, Angelita Solamalai, Sotira Katiri, Susan Hopkins, Ian Cropley, Marc Lipman
Journal: European Respiratory Journal (2013)

Amikacin treatment for multidrug resistant tuberculosis: how much monitoring is required?To the Editor:Multidrug-resistant tuberculosis (MDR-TB) is an increasing global problem.The World Health Organization (WHO) guidelines state that all patients suspected of MDR-TB should be given a group 2 injectable agent, usually an aminoglycoside.However, when taken for extended periods, these can cause nephrotoxicity, neurotoxicity and irreversible ototoxicity [1,2].Aminoglycoside-associated progressive hearing loss, from high to low conversational frequency sounds (0.5-2 KHz), affects at least 19% of MDR-TB patients [3,4].Most assessments are based on self-reported hearing loss, which is likely to significantly under-estimate the true proportion affected.Although both cochlear and vestibular functions can be impaired, the cochlea is predominantly damaged.This makes audiology testing, in particular serial audiograms that detect tone threshold changes, a useful way to assess ototoxicity, especially for non-conversational ultra-high frequency losses [3][4][5].
Iatrogenic stigma of mental illness
Authors: N. Sartorius
Journal: BMJ (2002)

The stigma attached to mental illness, and to the people who have it, is a major obstacle to better care and to the improvement of the quality of their lives.1 The World Psychiatric Association has recently initiated a global programme against stigma and discrimination because of schizophrenia.2 Twenty countries are participating in the programme, and others have expressed their interest in joining.3 The programme of the World Psychiatric Association is different from others in three ways. Firstly, it begins by an examination of experiences that patients and their families have had since the illness started. The analysis of accounts of their experiences in relation to society serves to select targets for interventions that will aim to reduce stigma and its consequences. Secondly, it involves different social sectors—for example, health ministries, social welfare services, labour ministries, non-governmental organisations, and the media. Thirdly, the programme is not a campaign but a long term engagement. Because of the strategy adopted for the programme, its focus differs from one place to another. For example, in Canada, one of the first targets of the programme was a change in procedures used in emergency departments that …
Note on a Peculiar Condition of the Skin in Paraplegia
Authors: D. Ferrier
Journal: BMJ (1879)

THE ERITISI( MEDICAL 7OURNAL 341 swellings, combined with the internal administration of carbolic acid, or sulphate of quinine.In some cases, these remedies were thought to do good, while in others they proved useless, if not detrimental, and Dr. Cabiadis is convinced that we know as little about the cure of this disease as we do about its essence.He concludes his interesting notes on this subject by expressing astonishment and regret that no public hospital exists in Bagdad, an ,extensive city of 150,000 inhabitants.*A large military hospital was built there by Midhat Pasha, on a fine and healthy site, but no use has been made of it.lle therefore suggests that the Government should turn it into a civil hospital for the benefit of the people of Bagdad.
Differential diagnosis of acute HBsAg positive hepatitis using IgM anti-HBc by a rapid, fully automated microparticle enzyme immunoassay
Authors: Nicolaos C. Tassopoulos, George V. Papaptheodoridis, Yiannis Kalantzakis, Evangelia Tzala, Johanna K. Delladetsima, Maria G. Koutelou, Paraskevi Angelopoulou, Angelos Hatzakis
Journal: Journal of Hepatology (1997)
Conserved Roles for Slit and Robo Proteins in Midline Commissural Axon Guidance
Authors: Hua Long, Christelle Sabatier, None Le Ma, Andrew Plump, Wenlin Yuan, David M Ornitz, Atsushi Tamada, Fujio Murakami, Corey S Goodman, Marc Tessier-Lavigne
Journal: Neuron (2004)
Relative effects of high saturated fatty acid levels in meat, dairy products, and tropical oils on serum lipoproteins and low-density lipoprotein degradation by mononuclear cells in healthy males
Authors: Sunmin Park, Jean T. Snook, Lori Bricker, Michael Morroco, Randall Van Voorhis, Elizabeth Stasny, Sonhee Park, Myoung-Sook Lee
Journal: Metabolism (1996)
Improving Patient Safety: Insights from American, Australian and British Healthcare
Authors: P. Anderson
Journal: BMJ (2003)

What ensued when a medical devices officer decided to explore the cupboards at his hospital is one of the most attention grabbing parts of this book. Chris Quinn, from Newcastle upon Tyne Hospitals NHS Trust, found more than 40 types of infusion pump, 25 of which were obsolete, and discovered that no nurse had had competency based training in their use. An increase in the number of infusion incidents from 1993 to 1996 at the trust has now been reversed, thanks to a training programme and the growth of what Mr Quinn describes as “a culture of …
Early Detection of Tuberous Sclerosis by l-123 IMP SPECT in a Neonate
Authors: MOTOO OSHIMA, HIROSHI YASUKOCHI
Journal: Clinical Nuclear Medicine (1994)

The authors used l-123 IMP SPECT imaging to detect tuberous sclerosis in a neonate. Two hours after normal birth, the baby had a seizure. Electrocephalography revealed an abnormal wave on the left temporal lobe. On the eighth day after the birth, brain SPECT Imaging was performed using N-isopropyl lodoamphetamine (l-123 IMP). The brain SPECT image showed marked uptake in the left fronto-temporal lobe, corresponding to the high-density area noted on computed tomography. One year later, l-123 IMP SPECT showed hypoperfusion corresponding to the calcified lesion seen on the CT scan. After surgical resection, this lesion was histologically proven to be tuberous sclerosis.
AGREEMENT BETWEEN CLINICAL, ECHOCARDIOGRAPHY AND NEUROHORMONAL RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY
Authors: Georgette E. Hoogslag, Ulas H&ouml;ke, Harriette Verwey, Joep Thijssen, Dominique Auger, Nina Ajmone Marsan, Ernst van der Wall, Martin Schalij, Jeroen Bax, Victoria Delgado
Journal: Journal of the American College of Cardiology (2012)
Further observations on renal transplants in man from cadaveric donors.
Authors: R. Y. Calne, L. Loughridge, J. B. MacGillivray, J. D. Swales
Journal: BMJ (1966)

In 1963 five cases of cadaveric renal transplantation in man were reported from this hospital (Calne et al., 1963a).Four of these patients died within two months of operation, the fifth was surviving after eight months.Fifteen further cadaveric transplants have since been performed, and we here report the results of the 20 cases.Three transplants were valuable thera- peutically, restoring the patients to a normal existence.Certain changes in calcium metabolism, blood pressure, and red-cell production are discussed in detail.
Diagnostic chelation challenge with DMSA: a biomarker of long-term mercury exposure?
Authors: H Frumkin, C C Manning, P L Williams, A Sanders, B B Taylor, M Pierce, L Elon, V S Hertzberg
Journal: Environmental Health Perspectives (2001)

Chelation challenge testing has been used to assess the body burden of various metals. The best-known example is EDTA challenge in lead-exposed individuals. This study assessed diagnostic chelation challenge with dimercaptosuccinic acid (DMSA) as a measure of mercury body burden among mercury-exposed workers. Former employees at a chloralkali plant, for whom detailed exposure histories were available (n = 119), and unexposed controls (n = 101) completed 24-hr urine collections before and after the administration of two doses of DMSA, 10 mg/kg. The urinary response to DMSA was measured as both the absolute change and the relative change in mercury excretion. The average 24-hr mercury excretion was 4.3 microg/24 hr before chelation, and 7.8 microg/24 hr after chelation. There was no association between past occupational mercury exposure and the urinary excretion of mercury either before or after DMSA administration. There was also no association between urinary mercury excretion and the number of dental amalgam surfaces, in contrast to recent published results. We believe the most likely reason that DMSA chelation challenge failed to reflect past mercury exposure was the elapsed time (several years) since the exposure had ended. These results provide normative values for urinary mercury excretion both before and after DMSA challenge, and suggest that DMSA chelation challenge is not useful as a biomarker of past mercury exposure.
Surgery for carotid artery stenosis: Author's reply
Authors: James F Toole
Journal: BMJ (2004)

EDITOR—I am pleased that my editorial has evoked responses about the looming epidemic of stroke, often the result of carotid artery disease. We hope that all risk factors will be reduced by careful attention to good health habits including diet, smoking, blood pressure control, etc, and in selected cases, platelet anti-aggregants and statins.1 For patients who, despite control of risk factors, …
Validation of different techniques for the diagnosis of ventilator-associated pneumonia. Comparison with immediate postmortem pulmonary biopsy.
Authors: A Torres, M el-Ebiary, L Padró, J Gonzalez, J P de la Bellacasa, J Ramirez, A Xaubet, M Ferrer, R Rodriguez-Roisin
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

To assess the accuracy of clinical parameters for the diagnosis of ventilator-associated (VA) pneumonia, as well as the diagnostic value of several invasive techniques, such as protected specimen brush (PSB), bronchoalveolar lavage (BAL), fiberoptic bronchial aspirates (FBAS), and percutaneous lung needle aspiration (PLNA), we compared the results of these techniques with the histopathology of immediate postmortem pulmonary biopsies, considered the "gold standard" reference test. We studied 30 mechanically ventilated patients (age 52 +/- 21 yr; mechanical ventilation period 9 +/- 7 days) who died in an intensive care unit. All patients received prior antibiotic treatment. The following procedures were performed immediately after death: bilateral PSB, BAL, FBAS, and PLNA, as well as bilateral minithoracotomies to obtain pulmonary biopsies as close as possible to the area sampled with the other techniques. According to the histopathology 18 patients had pneumonia and 12 did not. The presence of fever (sensitivity 55%, specificity 58%), purulent secretions (sensitivity 83%, specificity 33%), and chest radiograph infiltrates (sensitivity 78%, specificity 42%) could not differentiate in all instances presence from absence of pneumonia. Quantitative bacterial cultures of lung biopsies using 10(3) cfu/g as a cutoff point had low sensitivity (40%) and low specificity (45%) and could not differentiate the histologic absence or presence of pneumonia. Considering the histopathology of pulmonary biopsies as a gold standard, we found the following sensitivities for PSB, BAL, FBAS, and PLNA: 36, 50, 44, and 25%. The specificities were 50, 45, 48, and 79%, respectively. The sensitivities and specificities of different invasive techniques are much lower than those reported in clinical studies.(ABSTRACT TRUNCATED AT 250 WORDS)
In vitro absorption of some o-phthalate diesters through human and rat skin.
Authors: R C Scott, P H Dugard, J D Ramsey, C Rhodes
Journal: Environmental Health Perspectives (1987)

The absorption of undiluted phthalate diesters [dimethyl phthalate (DMP), diethylphthalate (DEP), dibutyl phthalate (DBP) and di-(2-ethylhexyl)phthalate (DEHP)] has been measured in vitro through human and rat epidermal membranes. Epidermal membranes were set up in glass diffusion cells and their permeability to tritiated water measured to establish the integrity of the skin before the phthalate esters were applied to the epidermal surface. Absorption rates for each phthalate ester were determined and a second tritiated water permeability assessment made to quantify any irreversible alterations in barrier function due to contact with the esters. Rat skin was consistently more permeable to phthalate esters than the human skin. As the esters became more lipophilic and less hydrophilic, the rate of absorption was reduced. Contact with the esters caused little change in the barrier properties of human skin, but caused marked increases in the permeability to water of rat skin. Although differences were noted between species, the absolute rates of absorption measured indicate that the phthalate esters are slowly absorbed through both human and rat skin.
Childhood Maltreatment and Psychopathology: A Case for Ecophenotypic Variants as Clinically and Neurobiologically Distinct Subtypes
Authors: Martin H. Teicher, Jacqueline A. Samson
Journal: American Journal of Psychiatry (2013)

Childhood maltreatment increases risk for psychopathology. For some highly prevalent disorders (major depression, substance abuse, anxiety disorders, and posttraumatic stress disorder) a substantial subset of individuals have a history of maltreatment and a substantial subset do not. The authors examined the evidence to assess whether those with a history of maltreatment represent a clinically and biologically distinct subtype.The authors reviewed the literature on maltreatment as a risk factor for these disorders and on the clinical differences between individuals with and without a history of maltreatment who share the same diagnoses. Neurobiological findings in maltreated individuals were reviewed and compared with findings reported for these disorders.Maltreated individuals with depressive, anxiety, and substance use disorders have an earlier age at onset, greater symptom severity, more comorbidity, a greater risk for suicide, and poorer treatment response than nonmaltreated individuals with the same diagnoses. Imaging findings associated with these disorders, such as reduced hippocampal volume and amygdala hyperreactivity, are more consistently observed in maltreated individuals and may represent a maltreatment-related risk factor. Maltreated individuals also differ from others as a result of epigenetic modifications and genetic polymorphisms that interact with experience to increase risk for psychopathology.Phenotypic expression of psychopathology may be strongly influenced by exposure to maltreatment, leading to a constellation of ecophenotypes. While these ecophenotypes fit within conventional diagnostic boundaries, they likely represent distinct subtypes. Recognition of this distinction may be essential in determining the biological bases of these disorders. Treatment guidelines and algorithms may be enhanced if maltreated and nonmaltreated individuals with the same diagnostic labels are differentiated.