Cytomegalovirus Vaccine in Renal Transplants
Authors: ROBERT F. BETTS
Journal: Annals of Internal Medicine (1979)

Editorials1 November 1979Cytomegalovirus Vaccine in Renal TransplantsROBERT F. BETTS, M.D.ROBERT F. BETTS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-780 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe understanding of the role of cytomegalovirus (CMV) in disease developing after renal transplantation has increased steadily since the initial realization that CMV infection commonly follows transplantation (1). With the recognition that patients acquired primary infection from virus transplanted with the allograft (2, 3) possible methods to prevent allograft-derived infection have been suggested (4, 5). Because morbidity due to cytomegalovirus is less frequent in persons who were antibody-positive before transplantation than in those developing primary infection (6, 7), it seemed logical to test whether vaccine-induced immunity would reduce CMV-associated morbidity. The study reported in this issue by Glazer and colleagues...References1. CRAIGHEADHANSHAWCARPENTER JJC Cytomegalovirus infection after renal allotransplantation. JAMA. 1967;201:725-8. CrossrefMedlineGoogle Scholar2. BETTSFREEMANDOUGLASTALLEYRUNDELL RRRTB Transmission of cytomegalovirus infection with renal allograft. Kidney Int. 1975;8:387-94. CrossrefGoogle Scholar3. HOSUWANSIRIKULDOWLINGYOUNGBLOODARMSTRONG MSJLJ The transplanted kidney as a source of cytomegalovirus infection. N Engl J Med. 1975;293:1109-12. CrossrefMedlineGoogle Scholar4. CHEESEMANRUBINSTEWARTTOLKOFF-RUBINCOSIMICANTELLGILBERTWINKLEHERRINBLACKRUSSELLHIRSCH SRJNAKJSJPPM Controlled clinical trial of prophylactic human-leukocyte interferon in renal transplantation: effects on cytomegalovirus and herpes simplex virus infections. N Engl J Med. 1979;300:1345-9. CrossrefMedlineGoogle Scholar5. MAYBETTSFREEMANANDRUS ARRC An analysis of cytomegalovirus infection and HLA antigen matching on the outcome of renal transplantation. Ann Surg. 1978;187:110-7. CrossrefMedlineGoogle Scholar6. BETTSFREEMANDOUGLASTALLEY RRRT Clinical manifestations of renal allograft derived primary cytomegalovirus infection. Am J Dis Child. 1977;131:759-763. MedlineGoogle Scholar7 SUWANSIRIKULRAODOWLINGHO SNJM Primary and secondary cytomegalovirus infection: clinical manifestations after renal transplantation. Arch Intern Med. 1977;137:1026-9. CrossrefMedlineGoogle Scholar8. GLAZERFRIEDMANGROSSMAN JHR Live cytomegalovirus vaccination of renal transplant candidates: a preliminary trial. Ann Intern Med. 1979;91:676-83. LinkGoogle Scholar9. HANSHAW J Cytomegaloviruses. Monogr Virol. 1978;3:1-23 Google Scholar10. DUVALLCASAZZAGRIMLEYCARBONEROWE CAPPW Recovery of cytomegalovirus from adults with neoplastic disease. Ann Intern Med. 1966;64:531-41. LinkGoogle Scholar11. DOWLINGSASLOWARMSTRONGHO JAJM Cytomegalovirus infection in patients receiving immunosuppressive therapy for rheumatic disorders. J Infect Dis. 1976;133:399-408. CrossrefMedlineGoogle Scholar12. LINNEMANNKAUFFMANFIRSTSCHIFFPHAIR CCHGJ Cellular immune response to cytomegalovirus infection after renal transplantation. Infect Immun. 1978;22:176-80. CrossrefMedlineGoogle Scholar13. LOPEZSIMMONSMAUERNAJARIANGOOD CRSJR. Association of renal allograft rejection with virus infections. Am J Med. 1974;56:280-9. CrossrefMedlineGoogle Scholar14. ARMSTRONGEVANSRAOHO JANM Viral infections in renal transplant recipients. Infect Immun. 1976;14:970-5. CrossrefMedlineGoogle Scholar15. CAPPELHESTERMANSTOUSSAINT ROC. Cytomegalovirus infection and graft survival in renal graft recipients. Arch Virol. 1978;56:149-56. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Infectious Diseases Unit University of Rochester School of Medicine Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNosocomial Herpesvirus InfectionsNosocomial Herpesvirus InfectionsHerpesVirus Infections: State of the ArtOptions for Prevention of Cytomegalovirus DiseaseHenry H. Balfour Jr., MDFever of Unknown OriginUse of Cytomegalovirus Immune Globulin to Prevent Cytomegalovirus Disease in Renal-Transplant RecipientsCytomegalovirus Disease: Can it be Prevented?HENRY H. BALFOUR JR., M.D.The Biology of CytomegalovirusesImmunsuppression 1 November 1979Volume 91, Issue 5Page: 780-782KeywordsCytomegalovirus infectionImmunityInfectious diseasesMorbidityRenal diseasesRenal transplantationTransplantationVaccines Issue Published: 1 November 1979 PDF DownloadLoading ...