tbuckley/cabot-search huggingface dataset:
A Case of Amoebic Brain Abscess
Authors: S. J. Powell, P. B. Neame
Journal: BMJ (1960)

DESMOID TUMOURBRrMH MEICAL JOL'RNA! changes in these tissues.Case 1 represents the acellular type, and Case 2 the more cellular type which recurred probably as the result of incomplete resection in the first instance.Neither case showed histological evidence of sarcomatous change, and so far there has been no evidence of metastases.There was a history of previous injury in both cases, but the women were past the climacteric.It may be that hormone disturbances bore some relation to development of the tumours. SummaryTwo multiparous women were operated on for a solid tumour in the chest wall.There was a history of injury in both cases, and histological examination of the resected specimens revealed a desmoid tumour arising from the intercostal tissue.The tumour was resected with the adjoining portion of the chest wall, and no recurrence had occurred in 24 and 12 months later respectively.This paper is published because we believe that these are the first two cases of desmoid tumour of the chest diagnosed and reported in this country.We thank Mr. B. B. Milstein and Mr. R. Rowlandson, the thoracic surgeons, for permission to report their cases.
Evidence for an environmental effect in the aetiology of insulin dependent diabetes in a transmigratory population.
Authors: H. J. Bodansky, A. Staines, C. Stephenson, D. Haigh, R. Cartwright
Journal: BMJ (1992)

OBJECTIVE--To examine whether children of families moving from an area of low incidence of childhood diabetes to one which is higher show a corresponding rise in disease incidence. DESIGN--Disease incidence study over 12 years. SETTING--Bradford District Metropolitan Council area. SUBJECTS--All subjects aged 0-16 years resident within the study area. MAIN OUTCOME MEASURES--The incidences of childhood diabetes in Asian and non-Asian families. RESULTS--The incidence of diabetes in Asian children increased from 3.1/100,000 per year in 1978-81 to 11.7/100,000 per year in 1988-90 (chi 2 for trend = 4.95, df = 1, p = 0.026) whereas that for other children remained constant at 10.5/100,000 per year. Over the entire study period rates were lower in Asian females (4.9/100,000 per year) than in Asian males (8.8/100,000 per year) whereas the reverse was true for other children (males 9.2/100,000 per year; females 12.0/100,000 per year) (test for common odds ratio: chi 2 = 3.81, df = 1, p = 0.052). CONCLUSIONS--Offspring of this transmigratory population had a rising incidence of childhood diabetes which was approaching that of the indigenous population. The data provide strong evidence for an environmental effect in the aetiology of insulin dependent diabetes.
Focus: Washington: Trying to do right by health reform
Authors: J Roberts
Journal: BMJ (1994)

Congressional elections are two weeks away, and Republicans are mildly optimistic that for the first time in half a century they will recapture majorities in both the House and the Senate. Most commentators say that such a change would cripple Bill Clinton's political agenda for the last two years of his term, but a few pundits - Republicans and even Democrats - say that such a “defeat” is Clinton's best chance of reviving health reform in 1995.

The Wall Street Journal pointed out that when a Democratic president has a Democratic congress he can ignore the Republican minority. But when the opposition controls the legislature the president must sit down and do some serious negotiating.

Most Republicans and Democrats are genuinely sorry that some kind of reform did …
Development and validation of a health-related quality-of-life questionnaire in patients with yellow jacket allergy
Authors: Joanne N.G.Oude Elberink, Jan G.R. de Monchy, David B.K. Golden, Jan-Leendert P. Brouwer, Gordon H. Guyatt, Anthony E.J. Dubois
Journal: Journal of Allergy and Clinical Immunology (2002)
The Pathogenesis of Infectious Disease
Authors: Jerry D. Smilack
Journal: JAMA (1983)

<i>Pediatrics, Neurology, and Psychiatry—Common Ground</i>is a greatsounding title. Three specialties working together on complex medical problems is a dream seldom realized. This book, written by two child neurologists and a consultant in child psychiatry, reflects some of the problems. The book has three main parts. The first, "General Considerations," deals briefly with the suggestion that all three disciplines work together and then reviews in more depth the central and peripheral nervous systems. Part 2, "Major Clinical Problems," covers 17 subjects, from autism, depression, hysteria, behavioral regression, enuresis, hyperactivity, memory problems, mental retardation, and learning problems to drug abuse and the dying child. The various chapters in part 2 have the same format, namely, diagnosis, differential diagnosis, etiology, treatment, and prognosis. Each has a section on correlation, including anatomic, biochemical, and physiological aspects of the particular problem. Numerous Five years have passed since Mims published the first edition of this
High incidence of hepatotoxicity of isoniazid treatment for tuberculosis chemoprophylaxis in patients with rheumatoid arthritis treated with methotrexate or sulfasalazine and anti-tumour necrosis factor inhibitors
Authors: J Vanhoof
Journal: Annals of the Rheumatic Diseases (2003)

Tumour necrosis factor (TNF) inhibition is a major breakthrough in the treatment of rheumatoid arthritis (RA). Infliximab, etanercept, and adalimumab are available TNF inhibitors that have been used and investigated extensively in RA.1–3 Reactivation of latent tuberculosis (TB) during anti-TNF treatment has been reported and therefore recommendations are made to screen patients for latent TB before starting TNF blocking agents.4

However, treatment with isoniazid (INH) can result in severe adverse effects. The two most important untoward effects of INH treatment are hepatitis and peripheral neuropathy. Peripheral neuritis associated with INH treatment can be reduced by the prophylactic administration of vitamin B6 (pyridoxine) 250 mg/week. INH associated hepatotoxicity can be severe and life threatening, with a death rate of 10%.5 …
Survival in Academy Award–Winning Actors and Actresses
Authors: Brooke Miskie
Journal: Annals of Internal Medicine (2003)

Letters7 January 2003Survival in Academy Award–Winning Actors and ActressesBrooke Miskie, BSc, Susan Near, BSc, and Robert Hegele, MDBrooke Miskie, BScUniversity of Western Ontario; London, Ontario N6A 5B8, Canada (Miskie, Near, Hegele)Search for more papers by this author, Susan Near, BScUniversity of Western Ontario; London, Ontario N6A 5B8, Canada (Miskie, Near, Hegele)Search for more papers by this author, and Robert Hegele, MDUniversity of Western Ontario; London, Ontario N6A 5B8, Canada (Miskie, Near, Hegele)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-1-200301070-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Redelemeier and Singh reported that among members of the Academy of Motion Picture Arts and Sciences, Academy Award winners had increased life expectancy compared with nonwinners (1). To determine whether a similar relationship between public recognition of personal accomplishment and extended longevity existed in members of other disciplines, we used the National Academy of Sciences (NAS) database (www4.nationalacademies.org/nas/nasdece.nsf/) to record the lifespan of member scientists who died during the 20th century, and we then stratified these results according to whether the NAS member had ever received the Nobel Prize. We matched 1626 nonwinner controls according to sex ...Reference1. Redelmeier DA, Singh SM. Survival in Academy Awardwinning actors and actresses. Ann Intern Med. 2001;134:955-62. [PMID: 11352696] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Western Ontario; London, Ontario N6A 5B8, Canada (Miskie, Near, Hegele) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSurvival in Academy Award–Winning Actors and Actresses Donald A. Redelmeier and Sheldon M. Singh Survival in Academy Award–Winning Actors and Actresses Donald A. Redelmeier and Sheldon Singh Survival in Academy Award–Winning Actors and Actresses Roland Staud Metrics Cited ByMortality and immortality: The Nobel Prize as an experiment into the effect of status upon longevityÜberlegungen zum Verhältnis von Bildung und Krankheit 7 January 2003Volume 138, Issue 1Page: 77-78KeywordsBirthDatabasesLife expectancyScientists ePublished: 7 January 2003 Issue Published: 7 January 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Bivalirudin reduces ischemic and hemorrhagic complications of percutaneous coronary intervention: Pooled data from 10 prospective studies in 6,134 patients
Authors: Frederick Feit, John A. Bittl, A. Michael Lincoff, Derek P. Chew, Neal S. Kleiman, Lars Wallentin, Harvey D. White, John Orniston, Richard Robson, Philip E. Aylward, Michael J. Attubato
Journal: Journal of the American College of Cardiology (2003)
Development and Application of a Model to Estimate the Impact of Type 1 Diabetes on Health-Related Quality of Life
Authors: Shin-Yi Wu, François Sainfort, Russell H Tomar, James L Tollios, Dennis G Fryback, Ronald Klein, Barbara EK Klein
Journal: Diabetes Care (1998)

To develop a simulation model to assess the impact of type 1 diabetes and its associated complications on health-related quality of life of a population.The methodology builds upon 1) an existing population model of type 1 diabetes progression, 2) an empirical study designed to measure state- and age-specific health statuses of type 1 diabetes, and 3) existing literature to quantify quality of life of the corresponding health status. Health statuses were measured in a group of type 1 diabetic patients using the Medical Outcomes Study short form 36 (SF-36). A published empirical regression equation was then used to predict corresponding Quality of Well-Being Index (QWB) scores from these assessments. The QWB scores were incorporated into a previously developed type 1 diabetes progression and cost simulation model. Sensitivity analyses on key parameters were performed, and the model was found to be robust.The augmented model can estimate quality-adjusted life years (QALYs) as well as costs associated with type 1 diabetes on any population of interest over any period of time. The model is used to compare intensive versus conventional treatment strategies using a simplified set of assumptions regarding the relative effects of these alternative treatments. With these assumptions, intensive strategy produces more QALYs than does conventional strategy and is cost-beneficial after 5 years.The model enables health planners to perform cost-effectiveness analyses to compare alternative treatment strategies for type 1 diabetes and support subsequent decision making.
Prevention of Cardiovascular Disease and Stroke
Authors: Gordon F. Tomaselli
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
Authors: Helen E Speedy, Maria Chiara Di Bernardo, Georgina P Sava, Martin J S Dyer, Amy Holroyd, Yufei Wang, Nicola J Sunter, Larry Mansouri, Gunnar Juliusson, Karin E Smedby, Göran Roos, Sandrine Jayne, Aneela Majid, Claire Dearden, Andrew G Hall, Tryfonia Mainou-Fowler, Graham H Jackson, Geoffrey Summerfield, Robert J Harris, Andrew R Pettitt, David J Allsup, James R Bailey, Guy Pratt, Chris Pepper, Chris Fegan, Richard Rosenquist, Daniel Catovsky, James M Allan, Richard S Houlston
Journal: Nature Genetics (2013)
Guidelines dismay disabled people unable to speak for themselves
Authors: A. Davis
Journal: BMJ (1999)

EDITOR—I am not just concerned about certain sections of the new BMA guidelines on withdrawing and withholding medical treatment1 —I am afraid.

I have severe spina bifida and am a full time wheelchair user. I was appalled at the Law Lords' judgment in 1993 which allowed Tony Bland to have his food and fluids removed. Now I see that the new BMA guidelines would allow yet more disabled people unable to speak in their own defence to have nutrition …
Benign Ulcers of the Greater Curvature
Authors: P. Cave
Journal: BMJ (1948)

In Birmingham not more than two children from one family were accepted, and the number of mothers (3,143) was very high as compared with the number of children (3,472).On the Birmingham ratio the staff used for this number was 868, and so there would be a release of about 2,275 mothers, or 3.6 for each member of staff.But this figure does not give a realistic picture of the nurseries from the man-power aspect.Of the mothers 359 were part-time workers and may be considered as equal to only half their number of full-time people.Again, the actual attendance of children was on an average only about 75% capacity, representing proportionately fewer mothers.Moreover, mothers temporarily off work through sickness were still allowed to send their children to the nursery for a period not exceeding three weeks, and although it is not known what allowance should be made for this factor it is clear that not every child attending had a mother at work at the time.On-the staff side Public Health Department records show that there were about 140 other people directly employed-e.g., cleaners and others, mostly part-time but equal to at least 70 full-time people.Behind the staff directly attached to the nurseries there were the other people, such as the doctors who inspected all nurseries once a fortnight, the extra staff at central kitchens, and all those involved in the erection of huts, adaptations of houses, equipment, alterations, and repairs.Each of the nurseries when fully staffed used three highly qualified people (nurses or nursery nurses), all in the short- supply category, plus nine to twelve others, according to the size of the nursery, and in estimating the man-power con- tribution this must be considered.The nurseries were not allowed to recruit staff between the ages of 18 and 30, but most of their workers could have done other forms of national work, although of course the 14-year-olds could not have been directed, and staff who had children of their own (sometimes accommodated in the' nursery!) would also have been free from compulsion.Since the issue of Circular 2388 by the Ministry of Health in May, 1941, it has been possible for " the children of any woman who is in employment" to use the nurseries, not
1102 THE COST-EFFECTIVENESS OF TELAPREVIR (TVR) IN COMBINATION WITH PEGYLATED INTERFERON-ALFA AND RIBAVIRIN (PR) FOR THE TREATMENT OF GENOTYPE 1 CHRONIC HEPATITIS C PATIENTS
Authors: S. Curtis, S. Cure, S. Gavart, L. Dearden, J. Fleischmann, M. Ouwens, S. Lee
Journal: Journal of Hepatology (2012)
The Universal Languages
Authors: Erlinda D. Austria
Journal: JAMA (1982)

In 1976,I traveled with the 40 dancers and musicians of the Philippine Bayanihan Dance Company on a ten-month cultural mission to Europe and the United States. I had graduated from the University of Santo Tomas in the Philippines the year before and completed my internship at the Veterans Memorial Hospital there, and I felt confident I could handle whatever medical problems the group would encounter. However, I had not expected my medical practice to go much beyond handing out medications for fever, cough, and colds and treating feet for splinters and cuts. I certainly had not expected to confront the first major medical problem of my medical career in East Berlin. While performing at the Palace de la Republik, a dancer fell and hit his knee. Minutes later, he had difficulty extending his leg. After an examination and x-ray films, the diagnosis of a torn meniscus was made. Surgery was
Platelet antibodies of the IgM class in immune thrombocytopenic purpura.
Authors: D B Cines, S B Wilson, A Tomaski, A D Schreiber
Journal: Journal of Clinical Investigation (1985)

The clinical course and response to therapy of patients with immune thrombocytopenic purpura (ITP) are not completely determined by the level of IgG present on the platelet surface. It is possible that antibodies of other immunoglobulin classes also play a role in platelet destruction in some of these patients. Therefore, we studied 175 patients with ITP for the presence of IgM anti-platelet antibodies using radiolabeled polyclonal or monoclonal anti-IgM. We observed that 57% of patients with clinical ITP had increased levels of IgM on their platelets, compared with normal controls and patients with thrombocytopenia who did not have ITP (less than 10%), (P less than 0.01). We obtained similar results using either radiolabeled polyclonal or monoclonal anti-IgM, reagents whose integrity was first characterized using erythrocytes coated with defined amounts of IgM antibody. Among patients with increased platelet-IgM there was a significant correlation both with the presence of increased platelet-C3 as well as the amount of platelet-C3 (P less than 0.01, r = 0.53). We demonstrated the presence of warm-reacting IgM anti-platelet antibodies in the plasma of two of these patients who were further studied. The isolated IgM fraction from these two plasmas was able to activate complement and place 3H-C3 on normal platelets. These studies demonstrate the presence of warm-reacting IgM anti-platelet antibodies in some patients with ITP. They suggest that the binding of complement to platelets by IgM antibodies may initiate platelet clearance as well as enhance the effect of IgG antibodies in ITP.
Oxidative Damage and Aging: Spotlight on Mitochondria
Authors: Nancy J. Linford, Samuel E. Schriner, Peter S. Rabinovitch
Journal: Cancer Research (2006)

Whereas free radical damage has been proposed as a key component in the tissue degeneration associated with aging, there has been little evidence that free radical damage limits life span in mammals. The current research shows that overexpression of the antioxidant enzyme catalase in mitochondria can extend mouse life span. These results highlight the importance of mitochondrial damage in aging and suggest that when targeted appropriately, boosting antioxidant defenses can increase mammalian life span.
Viral Infection of Infancy and Childhood: A Symposium [No. 10] of the Section on Microbiology, The New York Academy of Medicine
Authors: Samuel J. Hoffman
Journal: JAMA (1961)

This book is the work of 34 authors. They have approached the various diseases caused by viruses from the standpoints of history, characteristics of the virus, and the clinical findings caused by each virus. Chapters concerning physical properties of viruses, differentation between viruses, and infectivity characteristics, should be of interest to the microbiologist. They are highly technical. From the standpoint of the pediatrician, the chapters dealing with viruses as the cause of myocarditis, enteritis, dermatitis, respiratory tract infections, and central nervous system disease are of practical importance. The role of Coxsackie and ECHO viruses is stressed. Prophylaxis against influenza is discussed, and a routine for immunization of young children is recommended. Cultural and serological experiments on measles and varicella viruses are outlined. Because of its comprehensive coverage of the subject matter, this book should be excellent for reference use.
Enhanced Risk Assessment in Asymptomatic Individuals With Exercise Testing and Framingham Risk Scores
Authors: Samia Mora, Rita F. Redberg, A. Richey Sharrett, Roger S. Blumenthal
Journal: Circulation (2005)

National Cholesterol Education Program Adult Treatment Panel III (ATP III) guidelines recommend the use of Framingham risk scores (FRS) for cardiovascular assessment of asymptomatic individuals. We hypothesized that risk prediction could be improved with 2 non-ECG exercise test measures, exercise capacity (metabolic equivalents, or METs) and heart rate recovery (HRR).An asymptomatic cohort with baseline treadmill tests (n=6126; 46% women, FRS <20%) was followed up prospectively for 20 years. Individuals with low (median or less) HRR or METs experienced 91% of all cardiovascular disease (CVD) deaths (225/246). After FRS adjustment, low HRR and METs individually were highly significant predictors of CVD death, but low HRR and METs together were associated with substantially higher risk (adjusted hazard ratio compared with high HRR/high METs for women 8.51, 95% CI 3.65 to 19.84; for men, 3.53, 95% CI 2.03 to 6.15; P<0.001 for both). At 10-year follow-up, FRS-adjusted CVD death risk associated with low HRR/low METs was less than at 20 years but remained significant (women 3.83, 95% CI 1.09 to 13.47, and men 2.70, 95% CI 1.11 to 6.55). The application of HRR/METs information to FRS assessment identified those at high risk (>0.5% annual CVD mortality) in half of women with FRS 6% to 9% and 10% to 19% and just under half of men with FRS 10% to 19%. Low HRR/low METs was also associated with an increased relative risk of CVD death in individuals with low-risk FRS (FRS <6% in women and <10% in men), but absolute CVD mortality rates were low in this subgroup.Exercise testing may be a useful adjunct for clinical risk assessment in asymptomatic women with FRS 6% to 19% and men with FRS 10% to 19%.