tbuckley/cabot-search huggingface dataset:
Indoor air pollution and asthma. Results from a panel study.
Authors: B D Ostro, M J Lipsett, J K Mann, M B Wiener, J Selner
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Although there is abundant clinical evidence of asthmatic responses to indoor aeroallergens, the symptomatic impacts of other common indoor air pollutants from gas stoves, fireplaces, and environmental tobacco smoke have been less well characterized. These combustion sources produce a complex mixture of pollutants, many of which are respiratory irritants. We report here results of an analysis of associations between indoor pollution and several outcomes of respiratory morbidity in a population of adult asthmatics residing in the Denver, Colorado, metropolitan area. A panel of 164 asthmatics recorded in a daily diary the occurrence of several respiratory symptoms, nocturnal asthma, medication use, and restrictions in activity, as well as the use of gas stoves, wood stoves, or fireplaces, and exposure to environmental tobacco smoke. Multiple logistic regression analysis suggests that the indoor sources of combustion have a statistically significant association with exacerbations of asthma. For example, after correcting for repeated measures and autocorrelation, the reported use of a gas stove was associated with moderate or worse shortness of breath (OR, 1.60; 95% CI, 1.11-2.32), moderate or worse cough (OR, 1.71; 95% CI, 0.97-3.01), nocturnal asthma (OR, 1.01; 95% CI, 0.91-1.13), and restrictions in activity (OR, 1.47; 95% CI, 1.0-2.16). Among this panel of relatively moderate to severe asthmatics, the respiratory irritants produced by several domestic combustion sources were associated with increased morbidity.
Pituitary Involvement of Langerhans Cell Histiocytosis in an Adult Unveiled by FDG PET/CT
Authors: Huijun Ju, Yu Pan, Jing Lv, Xinwu Mao, Yifan Zhang
Journal: Clinical Nuclear Medicine (2014)

A 39-year-old woman with complains of polydipsia and dieresis was admitted to endocrinology service for evaluation and potential treatment of diabetes insipidus. During the hospitalization, the patient was found to have unexplained fever, for which an FDG PET/CT was performed to explore the source. The images revealed multiple regions of abnormal hypermetabolism throughout the body. Notably, there was an intense activity in the region of pituitary stalk. Pathological results after biopsy showed pituitary involvement of Langerhans cell histiocytosis.
THE RENAL ACTIVITY IN PREGNANT AND PUERPERAL WOMEN AS REVEALED BY THE PHENOLSULPHONEPHTHALEIN TEST
Authors: F. C. GOLDSBOROUGH
Journal: JAMA (1910)

Rountree and Geraghty<sup>1</sup>have recently recommended the use of phenolsulphonephthalein as a means of determining the functional activity of the kidneys, and consider it greatly superior to methylene blue, rosanilin, indigocarmin and various other substances which have heretofore been used for that purpose. The results which they obtained by its means were so satsatisfactory that we were led to hope that similar determinations might throw further light on the prognosis and treatment of certain cases of toxemia of pregnancy by showing some characteristic change in the functional activity of the kidneys. As it is known that marked alterations in the metabolism normally occur in the maternal organism under the influence of pregnancy and the puerperium, we subjected a number of normal pregnant and puerperal women to the test in order to determine to what extent their kidneys reacted to it, before applying it under diseased conditions. We employed the technic recommended by Rountree and Geraghty, is as follows:
Treatment of Hypertension-Reply
Authors: Nemat O. Borhani
Journal: JAMA (1978)

The Hypertension Detection and Follow-up Program (HDFP) is a multicenter cooperative effort designed to determine the effectiveness of systematic and sustained antihypertensive thereapy in reducing mortality in a wide spectrum of persons with elevated BP. The effort was initiated by the National Heart, Lung, and Blood Institute based on the following three major findings:   Prospective epidemiologic studies that showed persons with elevated BP are noticeably at high risk of cardiovascular disease mortality.  The results of clinical trials that showed pharmacologic treatment of high BP is efficacious for middle-aged men with average diastolic BP greater than 105 mm Hg.  Population surveys that demonstrated a poor control situation with less than 15% of all hypertensive persons detected and effectively treated. Thus, the HDFP has been investigating two specific questions: (a) In defined populations of different socioeconomic and ethnic composition, is it possible to detect the suspect hypertensive
Serum Insulin and Lipoprotein(a) Concentrations: The Jichi Medical School Cohort Study
Authors: Kazuo Inoue, Naoki Nago, Hitoshi Matsuo, Tadao Goto, Takeshi Miyamoto, Tomohiro Saegusa, Shizukiyo Ishikawa, Kazuomi Kario, Yosikazu Nakamura, Masahiro Igarashi
Journal: Diabetes Care (1997)

OBJECTIVE To examine the relationship between serum insulin and lipoprotein(a) [Lp(a)] concentrations in both sexes in a large population. RESEARCH DESIGN AND METHODS The authors conducted a cross-sectional investigation of fasting serum concentrations of insulin and Lp(a), other blood tests, blood pressures, anthropological measurements, physical activity index, smoking habit, alcohol consumption, and menopause. The subjects were 1,121 men and 1,480 women, ranging between 30 and 90 years of age, who were voluntary participants in the Jichi Medical Cohort Study and who resided in one of five rural communities in Japan. RESULTS In men, insulin, age, BMI, LDL cholesterol, triglycerides, glucose, and fibrinogen were significantly correlated with Lp(a). In women, insulin, age, LDL cholesterol, fibrinogen, and activated coagulation factor VII were significantly correlated with Lp(a). However, all correlations were weak in either sex. Insulin was inversely correlated with Lp(a) in both sexes. However, the coefficients were weak (r = −0.16 in mean and r = −0.06 in women). In the partial correlation analyses, Lp(a) was not significantly associated with insulin in either sex. The result was not influenced by selecting the subjects on the basis of detectable values of insulin and Lp(a) and stratifying them by serum glucose level. CONCLUSIONS There was no significant relationship found between serum insulin and Lp(a) concentrations in either sex of the cohort, which indicates that Lp(a) does not play a role in the increased risk of cardiovascular disease in hyperinsulinemic subjects.
Psychiatric Emergencies: Their Recognition and Management by the Internist.
Authors: Mathew Ross
Journal: Annals of Internal Medicine (1965)

s1 November 1965Psychiatric Emergencies: Their Recognition and Management by the Internist.Mathew Ross, M.D., F.A.C.P.Mathew Ross, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-911_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmong the more immediate, pressing, and vexing disorders that confront, confound, and challenge the internist in his role as a diagnostician and consultant are the psychiatric emergencies. This presentation is an effort to assist him in his role as an internist to arrive at a prompt, accurate diagnosis and to achieve practical management of these illnesses. It is not an effort to fashion him into a psychiatrist, full-fledged or otherwise.Clinical examples of the more subtle, yet nontheless common psychiatric emergencies are cited to illustrate (1) how the internist may extend his customary diagnostic acumen more deeply into the psychiatric... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Mathew Ross, M.D., F.A.C.P.Affiliations: Chestnut Hill, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 911-911 ePublished: 1 December 2008 Issue Published: 1 November 1965 PDF downloadLoading ...
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
Authors: John C. Byrd, Thomas S. Lin, James T. Dalton, Di Wu, Mitch A. Phelps, Beth Fischer, Mollie Moran, Kristie A. Blum, Brad Rovin, Michelle Brooker-McEldowney, Sarah Broering, Larry J. Schaaf, Amy J. Johnson, David M. Lucas, Nyla A. Heerema, Gerard Lozanski, Donn C. Young, Jose-Ramon Suarez, A. Dimitrios Colevas, Michael R. Grever
Journal: Blood (2006)
Effect of Extrasystoles on Idioventricular Rhythm
Authors: HERMAN O. KLEIN, ROBERT LEBSON, PAUL F. CRANEFIELD, BRIAN F. HOFFMAN
Journal: Circulation (1973)

When premature ventricular contractions (PVCs) occur in the idioventricular rhythm of patients with complete heart block (CHB), one of several rhythm alterations may occur: the postextrasystolic or returning cycle (RC) may be prolonged, unaltered, or even shortened without any apparent reason. To elucidate the mechanisms by which these alterations occur, the effect of spontaneous and of electrically induced PVCs was studied in five patients with CHB. Over 500 observations were obtained. PVCs occurring late in the basic cycle, i.e., after the T wave of the last spontaneous idioventricular beat, almost uniformly resulted in lengthening of the first RC. In sharp contrast, PVCs elicited early in the cycle, i.e., during the T wave, were followed by a shortened RC in 95% of instances. The underlying electrophysiologic mechanisms responsible for the relationship of RC length to degree of prematurity of the PVC are discussed.
Rugby union should ban contested scrums: Reality check is needed
Authors: Malcolm Cameron
Journal: BMJ (2006)

EDITOR—I write with reference to Bourke's personal view.1 There is no doubt that paraplegia is absolutely devastating. However, let's get things in proportion—based on Bourke's numbers, the risk of contracting a spinal injury is tiny. Bourke states he attends 25 home matches per season and has done so for 30 years; that makes 750 matches. I assume there are roughly the …
Re: Beat Roth, Frédéric D. Birkhäuser, Pascal Zehnder, et al. Readaptation of the Peritoneum Following Extended Pelvic Lymphadenectomy and Cystectomy Has a Significant Beneficial Impact on Early Postoperative Recovery and Complications: Results of a Prospective Randomized Trial. Eur Urol 2011;59:204–10
Authors: Florian Jentzmik, Andres Jan Schrader, Mark Schrader
Journal: European Urology (2010)
Fatal chronic cutaneous herpes simplex associated with thymoma and hypogammaglobulinaemia
Authors: S. BECK, D. SLATER, CHRISTINE I. HARRINGTON
Journal: British Journal of Dermatology (1981)

SUMMARY A patient is described who suffered from cutaneous herpes simplex for 9 years. A raediastinal tumour had been demonstrated radiologically 10 years prior to the onset of the skin disease and at autopsy the tumour was identified as a spindle cell thymoma. The patient also had hypogammaglobulinaemia.
Commission agrees framework to regulate genetic tests sold direct to consumers
Authors: S. Mayor
Journal: BMJ (2010)

Companies selling genetic tests directly to consumers must provide accurate and easy to understand information to enable purchasers to give fully informed consent, according to the first international framework on this rapidly expanding market that was agreed this week. Consent requires that users understand the nature of the test and the potential implications of the results.

The Common Framework of Principles for Direct to Consumer Genetic Testing Services has been developed by an international working group convened by the Human Genetics Commission, the UK government’s advisory body on new developments in human genetics. The group incorporated responses from a worldwide consultation before agreeing the final framework at a meeting …
Effect of frame rate, color gain, and filter setting on automated cardiac output measurement by spatio-temporal integraton of Doppler velocity profile in vivo
Authors: T. Hozumi, K. Yoshida, T. Akasaka, T. Takagi, S. Kaji, T. Kawamoto, T. Yagi, S. Morioka
Journal: Journal of the American College of Cardiology (1998)
The Consult Guys - A Trip to the Hardware Store: Is an MRI Safe?
Authors: Geno J. Merli, Howard H. Weitz
Journal: Annals of Internal Medicine (2014)

Web Exclusives17 June 2014The Consult Guys - A Trip to the Hardware Store: Is an MRI Safe?FREEGeno J. Merli, MD and Howard H. Weitz, MDGeno J. Merli, MD and Howard H. Weitz, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G14-3006 SectionsSupplemental MaterialAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Consult Guys bring a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations.For more videos from and information on The Consult Guys, visit www.annals.org/ConsultGuys. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Disclosures: Geno J. Merli, MD, reports the following: Research grants/contracts: Bristol-Myers Squibb, Bayer, sanofi-aventis; Consultancies: Bristol-Myers Squibb, Bayer, sanofi-aventis. Howard H. Weitz, MD, reports that he has no financial relationships or interests to disclose. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 June 2014Volume 160, Issue 12Page: CG6KeywordsConflicts of interestResearch grantsResearch reporting guidelines ePublished: 17 June 2014 Issue Published: 17 June 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.Loading ...
Lead effects on postural balance of children.
Authors: A Bhattacharya, R Shukla, R L Bornschein, K N Dietrich, R Keith
Journal: Environmental Health Perspectives (1990)

The postural sway responses of 63 children with a mean age of 5.74 years were quantified with a Force Platform technique. The average maximum (max) blood lead (PbB) of these children during the first 5 years of life was 20.7 micrograms/dL (range 9.2 to 32.5). The backward stepwise regression analysis for sway area response during the eyes-closed, no-foam test with all the covariates and confounders and the PbB parameters showed a significant relationship with peak or max PbB during the second year of life. These results are consistent with our previous study with a smaller group of children. The data have been analyzed to provide some insight into the role of various afferent for the maintenance of postural balance. The results suggests a hypothesis that if the max PbB had caused some level of impairment in the functional capacities or interconnectivity of the vestibular and/or proprioception systems at 2 years of age, then it is reasonable to assume that the redundancy in the postural afferent systems would naturally adapt to rely more on the remaining intact afferent system (in this case, vision).
Prevention of relapse in pediatric patients with acute leukemias and MDS after allogeneic SCT by early immunotherapy initiated on the basis of increasing mixed chimerism: a single center experience of 12 children
Authors: P Bader, T Klingebiel, A Schaudt, U Theurer-Mainka, R Handgretinger, P Lang, D Niethammer, JF Beck
Journal: Leukemia (1999)
Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1α/VP16 Hybrid Transcription Factor
Authors: Karen A. Vincent, Kou-Gi Shyu, Yuxia Luo, Meredith Magner, Rene A. Tio, Canwen Jiang, Mark A. Goldberg, Geoffrey Y. Akita, Richard J. Gregory, Jeffrey M. Isner
Journal: Circulation (2000)

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that regulates expression of genes involved in O(2) homeostasis, including vascular endothelial growth factor (VEGF), a potent stimulator of angiogenesis. We sought to exploit this native adaptive response to hypoxia as a treatment for chronic ischemia.A hybrid protein consisting of DNA-binding and dimerization domains from the HIF-1alpha subunit and the transactivation domain from herpes simplex virus VP16 protein was constructed to create a strong, constitutive transcriptional activator. After transfection into HeLa, C6, and Hep3B cells, this chimeric transcription factor was shown to activate expression of the endogenous VEGF gene, as well as several other HIF-1 target genes in vitro. The bioactivity of HIF-1alpha/VP16 hybrid gene transfer in vivo was examined in a rabbit model of hindlimb ischemia. Administration of HIF-1alpha/VP16 was associated with significant improvements in calf blood pressure ratio, angiographic score, resting and maximal regional blood flow, and capillary density (all P:<0.01).The HIF-1alpha/VP16 hybrid transcription factor is able to promote significant improvement in perfusion of an ischemic limb. These results confirm the feasibility of a novel approach for therapeutic angiogenesis in which neovascularization may be achieved indirectly by use of a transcriptional regulatory strategy.
ASSESSMENT OF MORPHOLOGICAL FEATURES OF PLAQUES WITH ULTRASOUND ATTENUATION IN PATIENTS WITH ACUTE CORONARY SYNDROME USING OPTICAL COHERENCE TOMOGRAPHY
Authors: Nobuhiko Maejima, Kiyoshi Hibi, Kenichiro Saka, Hiroyuki Suzuki, Zenkou Nagashima, Naoki Nakayama, Masayoshi Kiyokuni, Kozo Okada, Yasushi Matsuzawa, Masaaki Konishi, Katsutaka Hashiba, Mitsuaki Endo, Noriaki Iwahashi, Kengo Tsukahara, Yoshio Tahara, Masami Kosuge, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2011)
Increase in circulating CD4+CD25+Foxp3+ T cells in patients with Philadelphia-negative chronic myeloproliferative neoplasms during treatment with IFN-α
Authors: Caroline Hasselbalch Riley, Morten Krogh Jensen, Marie Klinge Brimnes, Hans Carl Hasselbalch, Ole Weis Bjerrum, Per thor Straten, Inge Marie Svane
Journal: Blood (2011)
The errors in our ways
Authors: Mary E Black
Journal: BMJ (2008)

Once, I prepared a comprehensive brief for the World Health Organization executive board recommending that it commission a chain of whorehouses across the war zone of what was then Yugoslavia. Thank heavens for a regional director with an eye for detail and a sense of humour: “Surely you mean warehouses, Dr Black?” More recently I examined a thesis for membership of the Faculty of Pubic Health Medicine. The candidate was pinkly embarrassed. I was kindly and magnanimous; we have all hit the wrong spellcheck button in our day, and …
Prevalence and risk factors for heart disease among males with hemophilia
Authors: Roshni Kulkarni, J. Michael Soucie, Bruce L. Evatt
Journal: American Journal of Hematology (2005)

There have been conflicting reports in the literature about the protective effect of hemophilia on the occurrence of ischemic heart disease (IHD). Circulatory disease has been reported as the second most common cause of death in persons with hemophilia in the United States. In addition to diabetes and hypertension, high levels of FVIII, as may occur during factor concentrate infusions, may increase IHD risk in this population. To estimate the prevalence of heart disease and examine factors associated with IHD and other heart diseases among persons with hemophilia, we analyzed data collected from the medical records of 3,422 males with hemophilia living in six U.S. states from 1993 to 1998. Heart disease cases were ascertained from among 2,075 persons who were hospitalized at least once during the 6-year period. Of these, 48 were diagnosed with IHD and 106, with other types of heart disease. The age-specific prevalence of IHD ranged from 0.05% in those under 30 years to 15.2% in those 60 years or older. Hospital discharge rates in males with hemophilia with IHD and other types of heart disease were lower compared to rates in age-matched U.S. males. In our cohort, as in the general population, IHD was independently associated with age, hypertension, diabetes, and hyperlipidemia. Other heart diseases were associated with HIV infection, hypertension, hemophilia B, and diabetes. In summary, persons with hemophilia have unique risk factors such as infusion of factor concentrates and infection with HIV that may predispose them to heart disease as their life expectancy increases. Am. J. Hematol. 79:36–42, 2005. © 2005 Wiley-Liss, Inc.
471 Effect of a topical nasal steroid on GM-CSF, IL-6, IL-8 and HLA-D expression by nasal epithelial cells in seasonal allergic rhinitis (SAR)
Authors: I SULAKVELIDZE, K NAKANO, M CONWAY, P EDNEY, R BRATTSAND, E DUKU, C GOLDSMITH, J DOLOVICH
Journal: Journal of Allergy and Clinical Immunology (1996)
NHS wastes at least 1bn a year on avoidable errors, claims health secretary
Authors: G. Iacobucci
Journal: BMJ (2014)

Medication errors, avoidable infections after surgery, and other errors in hospitals are wasting at least £1bn (€1.25bn; $1.6bn) of NHS money each year, England’s health secretary, Jeremy Hunt, has claimed.

Hunt said a new report commissioned by the Department of Health provided evidence of the “wasteful and expensive” levels of poor care in the NHS.1 The report, produced by the consultancy firm Frontier Economics, estimated that preventable incidents were costing the NHS at least £1bn a year and possibly as much as …
Direct-to-Consumer Advertising — Education or Emotion Promotion?
Authors: Sidney M. Wolfe
Journal: New England Journal of Medicine (2002)

During the past two decades, there has been an irreversible change in the nature of the doctor–patient relationship. Patients are seeking much more medical information and are actively participating in decisions affecting their health. Intruding into this trend has been the rise of direct-to-consumer promotion, which, in its initial thrust, bypasses primary care doctors and other physicians. Although increased access by patients to accurate, objective information about tests to diagnose and drugs to treat illnesses is an important advance, confusion arises when commercially driven promotional information is represented as educational. Two articles in this issue of the Journal address the . . .
A piece of my mind. Primary care
Authors: J. L. Teich
Journal: JAMA (1988)

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