tbuckley/cabot-search huggingface dataset:
A Medical Status Exam
Authors: Ronald Pies
Journal: JAMA (1981)

On those days when my ego is barely in control of my id, I often reach the conclusion that nonpsychiatric physicians simply don't know enough medicine. This may sound ironic from one whose speciality receives the very same criticism—and often with justification.<sup>1</sup>And yet, the experience of the psychiatric consultant in a busy university hospital tends to confirm my impression. The medicine that is "unknown" to many internists, emergency physicians, and other nonpsychiatrists is the medicine that relates to psychiatric patients. One sees this deficit in the many requests for psychiatric consultations in the absence of any reasonable attempt to rule out organic pathology. Thus, Johnson<sup>2</sup>showed that one half to one third of referring physicians are using psychiatry as a primary care resource, often neglecting to take histories or perform physical examinations. One can reasonably argue that psychiatrists ought to embrace the medical model and even perform
Coronary artery bypass graft surgery after thrombolytic therapy in the thrombolysis in myocardial infarction trial, Phase II (TIMI II)
Authors: Bernard J. Gersh, James H. Chesebro, Eugene Braunwald, Costas Lambrew, Eugene Passamani, Rachel E. Solomon, Allan M. Ross, Richard Ross, Michael L. Terrin, Genell L. Knatterud
Journal: Journal of the American College of Cardiology (1995)
Jingoism in pharmaceutical promotion
Authors: A Herxheimer
Journal: BMJ (1989)

The nature of the relation between multiple sclerosis and vitamin B12 deficiency in these cases is unclear; as it might, however, offer a clue to the understanding of an obscure neurological disease4 and as vitamin B12 is widely prescribed as a placebo in multiple sclerosis it seems to be an association worth more detailed investigation.I would there- fore be grateful to hear of any further examples from your readers.
Esophageal Distensibility as a Measure of Disease Severity in Patients With Eosinophilic Esophagitis
Authors: Frédéric Nicodème, Ikuo Hirano, Joan Chen, Kenika Robinson, Zhiyue Lin, Yinglian Xiao, Nirmala Gonsalves, Mary J. Kwasny, Peter J. Kahrilas, John E. Pandolfino
Journal: Clinical Gastroenterology and Hepatology (2013)
Vagotomy and peptic ulcer.
Authors: C V Ruckley
Journal: BMJ (1970)

Uterus in a Male SIR,-A man aged 40 was admitted in July 1967 with a reducible right inguinal hernia and an undescended left testis.The right testis, normal in size and consistency, was present in the scrotum.Exploration of the right inguinal canal revealed a completely patent processus vaginalis with the testis inside the sac.On applying traction to the testis, an oval mass,
Storing Serum for Retrospective Diagnosis
Authors: Samuel Vaisrub
Journal: JAMA (1980)

Equipped with the newer radioisotopic dating devices, geologists, archeologists, and anthropologists often return to old excavation sites to reassess with greater accuracy previous dating estimates based on less sophisticated methods. Unfortunately, until recently medical epidemiologists have not had the same ready access to relics of old epidemics to reassess previous diagnosis. Unlike excavations, diseases are evanescent. Still, impermanent as an epidemic disease may be, it can be made to leave at least one long-lasting source for future investigation. Serum of infected persons can be stored for future studies with more advanced techniques. For instance, examination of serum obtained in 1965 during a minor outbreak of pneumonia in St Elizabeth Hospital in Washington, DC, disclosed 14 years later<sup>1</sup>the presence of live<i>Legionella pneumophila</i>, as well as that of antibodies to this organism. Not only did the isolation of the organism in embryonated eggs and the demonstration of its antibodies
FRACTURE OF THE HEAD OF THE FEMUR, WITH DISLOCATION ON THE DORSUM OF THE ILIUM
Authors: Guy Hinsdale
Journal: JAMA (1923)

The great rarity of fracture of the femoral head makes this case worthy of record. It occurred in a woman, aged 55, whose weight was about 160 pounds (72.5 kg.). She fell in attempting to jump from a motorboat to a wharf; she had reached forward to take a hand offered to her, and in jumping tripped over the gunwale of the boat and fell on the wharf, striking her left hip. She was immediately conscious of a severe injury, and stated that she had dislocated the right hip joint. She was unable to rise or move the limb, and was carried a short distance to her home. I saw her at the landing, and took her to her room, where an examination disclosed the thigh partly flexed; the foot inverted; the limb shortened, and a slight crepitus on effort at rotation. The deformity was typical of dislocation on the
Dissociation of Reticuloendothelial Cell and Hepatocyte Functions in Alcoholic Liver Disease: A Clinical Study with a New Tc-99m-labeled Hepatobiliary Agent
Authors: BHASKARA K. RAO, G JOHN WEIR, LIONEL M. LIEBERMAN
Journal: Clinical Nuclear Medicine (1981)

Tc-99m-sulfur colloid scintigrams were abnormal in four patients with hepatic dysfunction due to chronic alcohol abuse. Minimal uptake of radiocolloid in the liver suggested local reticuloendothelial (RE) cell failure. Imaging with a new hepatobiliary agent, Tc-99m-PIPIDA, revealed rapid hepatic accumulation and excretion of radiotracer with adequate visualization of the organ. Scintigraphic findings in these patients indicated a dissociation of hepatocyte and RE cell functions. Demonstration of adequate hepatocyte function with severe RE failure in alcoholic liver disease using a Tc-99m-labeled hepatobiliary agent has not been previously reported.
Concordance for Sex and the Pseudoautosomal Gene Hypothesis Revisited: No Evidence of Increased Sex Concordance in a Nationwide Finnish Sample of Siblings With Paternally Derived Schizophrenia
Authors: Dirk Lichtermann, Iiris Hovatta, Joseph D. Terwilliger, Leena Peltonen, Jouko Lönnqvist
Journal: American Journal of Psychiatry (1998)

Objective:This study set out to determine, in a homogeneous sample with nationwide coverage in Finland, whether siblings treated for schizophrenia are more often of the same sex than expected by chance, and whether this is especially so when the disorder is transmitted by their fathers.Method:Finnish social and health insurance files as well as hospital discharge registers were searched for probands with schizophrenia from a birth cohort spanning 30 years. Nuclear families were identified by cross-linkage with the national birth register, and the sex distribution observed in multiply affected sibships was compared with expected distributions by maximum likelihood analysis.Results:In the subset of multiply affected sibships with one parent who had schizophrenia (84 fathers and 120 mothers), the observed sex distribution did not deviate from the expected pattern. However, a small and marginally significant excess of sex concordance emerged from the total sample of 1,942 sibships in which there were at least two affected members, irrespective of the parents’ affection status.Conclusions:The results indicate that no above-chance sex concordance in sibships multiply affected with paternally transmitted schizophrenia is present in the genetically homogeneous population of Finland. In view of a virtually unbiased and complete ascertainment procedure and sample sizes one to two orders of magnitude larger than those in previous studies, the authors attribute prior findings of such a concordance to sampling artifacts or chance fluctuations and finally conclude that except for regional genetic isolates, there is no epidemiologic evidence that a gene accounting for substantial susceptibility to schizophrenia in a greater proportion of cases resides in the pseudoautosomal region of the sex chromosomes. Am J Psychiatry 1998; 155: 1365-1375
Abstract 4542: Dose-dependent effects of progestins on progesterone receptor activity and target gene expression: less is more
Authors: Hilary Wade, Donald McDonnell, Myles Brown
Journal: Cancer Research (2011)

Abstract While the molecular mechanisms by which the progesterone receptor (PR) regulates breast tumor growth and metastasis have not been fully elucidated, recent studies highlight the fact that PR has a complex role in breast cancer progression that may be dependent on ligand dose. For example, data from the Women's Health Initiative trial suggest that low-dose progestins used in combination with estrogen are associated with an increased risk of invasive breast cancer compared to estrogen alone. On the other hand, high-dose progestin therapy has been used as an effective front-line and second-line treatment for advanced, metastatic breast cancer. To investigate this paradox, we undertook studies to identify aspects of PR biology that respond differently to treatment with low or high doses of progestins. Interestingly, we found that treatment of T47D breast cancer cells with low-dose progestins generates a significantly more robust induction of a subset of PR target genes, including the cell cycle regulators cyclin D1 and E2F1, than treatment with high-dose progestins. Furthermore, we show that varying doses of progestins have differential effects on the receptor itself, including the subcellular localization, phosphorylation and subsequent turnover of PR. At the level of transcriptional regulation, our ChIP analyses have led us to hypothesize that the strength of PR activation of target gene expression may hinge upon the ratio of phospho-PR versus unmodified PR that is recruited to enhancer elements. This dose-dependent effect may result in the formation of different PR transcriptional complexes and explain the diverse downstream biologies that are regulated by varying levels of progestins throughout the female reproductive cycle and in diseases such as breast cancer. Given the wide range of medical therapies that utilize progestins, our findings may have important clinical implications. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4542. doi:10.1158/1538-7445.AM2011-4542
Abstract 1516: Melanocyte activation by UVR-induced calprotectin.
Authors: Kristine von Maltzan, Stephanie H. Shirley, Donna F. Kusewitt
Journal: Cancer Research (2013)

Abstract Melanoma is the most common cause of skin cancer death, although it accounts for only 5% of all skin cancers. Epidemiologic and clinical observations have shown that the ultraviolet (UVR) component of sunlight is the most important etiologic factor in melanoma; however, the precise mechanisms by which UVR drives melanomagenesis are unknown. Mutations in oncogenes and tumor suppressor genes have been identified in melanomas, but most of these are not the UVR signature mutations found in non-melanoma skin cancers. This suggests an indirect role for UVR in melanomagenesis, likely as a tumor promoter. UVR is a potent inducer of keratinocyte-derived paracrine and melanocyte/melanoma cell-derived autocrine factors that profoundly affect melanocyte/melanoma cell gene expression and behavior. Many of these mediators are also potent proinflammatory signals that create an inflammatory environment with additional effects on untransformed and transformed melanocytes. We have identified calprotectin, a secreted heterodimer of S100A8 and A9, as one of these mediators. UVR exposure induces S100A8 and A9 transcription in and calprotectin release from human keratinocytes and melanocytes. Human melanocytes and melanoma cells constitutively express TLR4, one of the receptors for calprotectin. Treatment of human melanocytes and melanoma cells with exogenous calprotectin enhances their proliferation, migration, and invasiveness. UVR-induced calprotectin secretion by melanocytes/melanoma cells and surrounding keratinocytes activates melanocytes/melanoma cells and may thus promote melanomagenesis. Citation Format: Kristine von Maltzan, Stephanie H. Shirley, Donna F. Kusewitt. Melanocyte activation by UVR-induced calprotectin. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1516. doi:10.1158/1538-7445.AM2013-1516
Resistance of flu virus to oseltamivir is growing, US study shows
Authors: S. Mayor
Journal: BMJ (2009)

Influenza A viruses that are resistant to oseltamivir (Tamiflu) are becoming more prevalent, the latest figures from the United States show.

Nearly all (98.5%) of influenza A (H1N1) viruses tested from the early 2008-9 flu season were resistant to oseltamivir ( JAMA 2009;301:1034-41, doi:10.1001/jama.2009.294). In the previous year 12% of these viruses were found to be resistant to the drug. The viruses were tested as part of ongoing surveillance by the Centers for Disease Control and Prevention (CDC), Atlanta.

The increase in drug resistance prompted the CDC to issue interim guidance to doctors at the end of 2008 recommending that …
The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition
Authors: Giada Bianchi, Laura Oliva, Paolo Cascio, Niccolò Pengo, Francesca Fontana, Fulvia Cerruti, Andrea Orsi, Elena Pasqualetto, Alexandre Mezghrani, Valeria Calbi, Giovanni Palladini, Nicola Giuliani, Kenneth C. Anderson, Roberto Sitia, Simone Cenci
Journal: Blood (2009)
SERUM CREATINE PHOSPHOKINASE (CPK)
Authors: FRANK A. GRAIG
Journal: Annals of Internal Medicine (1965)

Letters and Comments1 April 1965SERUM CREATINE PHOSPHOKINASE (CPK)FRANK A. GRAIG, M.D., J. CRISPIN SMITH, PH.D.FRANK A. GRAIG, M.D.Search for more papers by this author, J. CRISPIN SMITH, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-854 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: We read with great interest the recent paper by Hess and associates, entitled "Serum Creatine Phosphokinase (CPK) Activity in Disorders of Heart and Skeletal Muscle" (Ann. Intern. Med. 61: 1015, 1964). Although most of the findings of the authors are in agreement with ours, there are several points that deserve comment and clarification.1. The method used by the authors to determine serum CPK activity is based on the "forward" reaction. This method is known to be less sensitive than those based on the "reverse" reaction (1). In our experience with the "forward" reaction, we obtained some zero...References1. ENNORROSENBERG AHH: Some properties of creatine phosphokinase. Biochem. J. 57: 203, 1954. CrossrefMedlineGoogle Scholar2. GRAIGSMITH FAJC: Influence of abnormal thyroid function on serum creatine phosphokinase (CPK) (abstract). 46th Meeting of the Endocrine Society, 1964. Google Scholar3. HUGHES BP: A method for the estimation of serum creatine kinase and its use in comparing creatine kinase and aldolase activity in normal and pathological sera. Clin. Chim. Acta 7: 597, 1962. CrossrefMedlineGoogle Scholar4. NIELSENLUDVIGSEN LJ: Improved method for determination of creatine kinase. J. Lab. Clin. Med. 62: 159, 1963. MedlineGoogle Scholar5. COLOMBORICHTERICHROSSI JPRE: Serum-Kreatin-Phosphokinase: Bestimmung and Diagnostische Bedeutung. Klin. Wschr. 40: 37, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montefiore Hospital and Medical Center New York City, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1965Volume 62, Issue 4Page: 854-855KeywordsCreatineCreatinine phosphokinaseHeart diseasesMyocardiumSkeletal muscles ePublished: 1 December 2008 Issue Published: 1 April 1965 PDF downloadLoading ...
THE COMPETITION BETWEEN P-AMINO-HIPPURIC ACID (PAH) AND DIODRAST FOR RENAL EXCRETION AND EXTRACTION IN MAN 1
Authors: Bertil Josephson, Jan Ek, Härje Bucht, Lars Werkö, Julia Kallas, Arne Grieg
Journal: Journal of Clinical Investigation (1953)

Results of renal vein catheterization experiments 1 to 4 PAH Diodrast
Intraoperative hemodynamic modifications during pediatric orthotopic liver transplantation
Authors: M. Carlier, L. van Obbergh, F. Veyckemans, J. L. Scholtes, J. M. Gouverneur, B. F. Gribomont, D. Moulin, M. Reynaert, B. de Hemptinne, J. B. Otte
Journal: Intensive Care Medicine (1989)
Modifications in breast cancer presentation patern in Goiânia, Brazil: descriptive analyzes of a population based of 15 years in a developing country.
Authors: R Freitas-Júnior, E Martins, NM Freitas, M Curado, J Oliveira, CB Silva
Journal: Cancer Research (2009)

Abstract Abstract #6095 Objective: To epidemiologically describe breast cancer among women living in Goiania, Brazil. Patients and Methods: cases were identified from the Population-Based Cancer Registry of Goiania for the period from 1989 to 2003. The variables studied were age, diagnostic method, topographic sublocation, morphology and breast cancer extent. Frequency analyses were carried out on the variables and means and medians for the age were determined. The SPSS® 15.0 software was used for statistical analyses. Results: 3,204 breast cancer cases were collected. The mean age was 56 years and the median was 53 years. Histological confirmation increased from 86.8% to 96.9%. Over the first five-year period, 91.3% of the cases did not present any specific location for the tumor, while 84.7% did not in the second and 59.1% in the third. Infiltrating ductal carcinoma (IDC) was the most frequent type, with 2,627 cases (82%). Regarding extent, 45.6% of the cases were found to be localized and 10.2% presented distant metastases. The in-situ case rate was 0.2% in 1989-1993 and increased to 6.2% in 1999-2003. On the other hand, the advanced case rate was seen to decrease from 24.1% to 6.3%. Discussion: The diagnostic profile of breast cancer in the city of Goiania is changing. Substantial increases in the numbers of early breast cancer are occurring, to the detriment of the numbers of advanced cases. This therefore suggests that the sporadic screening programs used up to the present time have in some way changed the face of breast cancer in our region. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6095.
Coronary excimer laser angioplasty: Reduced complications and indium-111 platelet accumulation compared with thermal laser angioplasty
Authors: Timothy A. Sanborn, Dimitrios Alexopoulos, Jonathan D. Marmur, Hirshel Kahn, Juan Jose Badimon, Lina Badimon, Valentin Fuster
Journal: Journal of the American College of Cardiology (1990)
Effect of variation in dietary NaCl intake on the intrarenal distribution of plasma flow in the rat
Authors: Roland C. Blantz, John D. Wallin, Floyd C. Rector, Donald W. Seldin
Journal: Journal of Clinical Investigation (1972)

The effect of dietary variation in sodium chloride intake on the intrarenal distribution of plasma flow was investigated in rats using the antiglomerular basement membrane antibody technique. Rats were placed on a liquid diet containing either 9.86 (n = 9) or 0 (n = 9) mEq NaCl/daily portion for 2 wk. Labeled antibody was injected and the diets were reversed. After an additional 2 wk period, antibody labeled with a different radionuclide was injected and the animals were sacrificed. Fractional plasma flow distribution was then calculated for each dietary period. No change in flow to any cortical region could be detected. In six additional awake rats on identical dietary regimen, total plasma flow was estimated by the clearance of hippuran-(131)I. No change in this parameter occurred with changes in NaCl intake. We conclude, therefore, that no change in either total renal plasma flow or intracortical distribution of plasma flow occurs with wide variations in dietary sodium chloride intake in the rat. The implications of this constancy of regional plasma flow are discussed with reference to presumed concomitant alterations in the intrarenal distribution of nephron filtration rate.
False Patients/Real Patients: A Spectrum of Disease Presentation
Authors: Theodore Nadelson
Journal: Psychotherapy and Psychosomatics (1985)

This paper presents a synthesis of varying frameworks and value systems in which all patients are viewed by clinicians. A gradient of behaviors is arrayed which places disease simulation (Munchausen syndrome, malingering) at one end of a spectrum, with the other end anchored by 'real' disease. Between these two polarized opposites are placed the patients with 'psychological' origins to somatic presentations. These patients often called 'crocks' are somewhat different from those patients who present with disease simulation. Such patients are often referred to as 'crooks' in that they are absolutely false in their presentation and aware of such deception. The advantage of this particular schema is that it presents a gradient of behavior instead of isolated categorization. As such it is much more easily understood and used by clinicians and it presents the 'normal' and 'abnormal' within a single conceptual gradient instead of discreet categories.
Cathepsin B Mediates Caspase-Independent Cell Death Induced by Microtubule Stabilizing Agents in Non-Small Cell Lung Cancer Cells
Authors: Linda E. Bröker, Cynthia Huisman, Simone W. Span, José A. Rodriguez, Frank A. E. Kruyt, Giuseppe Giaccone
Journal: Cancer Research (2004)

Abstract We have previously reported that the microtubule stabilizing agents (MSAs) paclitaxel, epothilone B and discodermolide induce caspase-independent cell death in non-small cell lung cancer (NSCLC) cells. Here we present two lines of evidence indicating a central role for the lysosomal protease cathepsin B in mediating cell death. First, inhibition of cathepsin B, and not of caspases or other proteases, such as cathepsin D or calpains, results in a strong protection against drug-induced cell death in several NSCLC cells. Second, MSAs trigger disruption of lysosomes and release and activation of cathepsin B. Interestingly, inhibition of cathepsin B prevents the appearance of multinucleated cells, an early characteristic of MSA-induced cell death, pointing to a central, proximal role for cathepsin B in this novel cell death pathway.
Ultrastructure of the Dog Cardiac Muscle Cell
Authors: ZANE PRICE, BILLIE EIDE, MYRON PRINTZMETAL, CHARLES CARPENTER
Journal: Circulation Research (1959)

Observations on the cellular structure of the dog heart as seen in the electron microscope are described. Electronmicrographs illustrate the ultrastructure of the dog myocardial cell, especially the relationships of the intercalated disc and the sarcolemma to form the cell boundaries and the relationships of the myofibrils and "Z" bands to the sarcolemma which result in an "accordion-like" appearance of the cell after contraction.
328 IS HUMAN PLACENTA-DERIVED STEM CELLS AS A THERAPEUTIC REAGENT IN HEPATIC DISEASES POSSIBLE?
Authors: S.G. Hwang, G.J. Kim, J.-U. Jung, K.-S. Shin, J.-Y. Song, M.-J. Lee, W.H. Kim, G.I.l. Kim, S.-W. Kwon, K.S. Rim
Journal: Journal of Hepatology (2009)