tbuckley/cabot-search huggingface dataset:
Megaloblastic anaemia and methotrexate treatment
Authors: Annemette Oxholm, Kristian Thomsen
Journal: British Journal of Dermatology (1986)

Journal Article Megaloblastic anaemia and methotrexate treatment Get access Annemette Oxholm, Annemette Oxholm Department of Dermatology, The Finsen Institute, 49 Strandboulevarden, DK‐2100 Copenhagen 0, Denmark. Search for other works by this author on: Oxford Academic Google Scholar Kristian Thomsen Kristian Thomsen Department of Dermatology, The Finsen Institute, 49 Strandboulevarden, DK‐2100 Copenhagen 0, Denmark. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 114, Issue 2, 1 February 1986, Pages 268–269, https://doi.org/10.1111/j.1365-2133.1986.tb02813.x Published: 01 February 1986
Multidrug-resistant tuberculosis in children: evidence from global surveillance
Authors: Matteo Zignol, Charalambos Sismanidis, Dennis Falzon, Philippe Glaziou, Masoud Dara, Katherine Floyd
Journal: European Respiratory Journal (2012)

Multidrug-resistant tuberculosis (MDR-TB) can affect persons of any age, but it remains unknown whether children are more or less likely than adults to have MDR-TB. Representative drug resistance surveillance data reported to the World Health Organization between 1994 and 2011 were analysed to test the association between MDR-TB and age group (children aged &lt;15 years versus adults aged ≥15 years), using odds ratios derived by logistic regression with robust standard errors. Of 85 countries with data from nationwide surveys or surveillance systems, 35 reported at least one paediatric MDR-TB case. Aggregated data on age and drug susceptibility testing for 323 046 tuberculosis cases notified in these 35 countries were analysed. Odds ratios for MDR-TB in children compared to adults varied widely between countries. In Germany, Namibia, South Africa, the UK and the USA, MDR-TB was positively associated with age &lt;15 years. In the remaining countries no association was established. Despite the limitations intrinsic to the use of surveillance data and to the challenges of diagnosing childhood tuberculosis, our analysis suggests that proportions of MDR-TB in children and adults are similar in many settings. Of particular concern is the association found between age &lt;15 years and MDR-TB in southern African countries with high HIV prevalence.
Stippling of the Retina
Authors: Nathan Sonkin
Journal: New England Journal of Medicine (1963)

LEAD poisoning was a subject of major importance during the first four decades of this century because of the absorption of lead from paint, especially among children and painters. Intoxication with lead products was also common among battery workers and those unfortunate enough to ingest it from the insecticide residues on fruits and vegetables. It is no longer as prevalent because of the safeguards that have been introduced in lead-free paints and the greater sophistication of industrial users of lead. Nevertheless, it is still an important problem in the wire and battery industries.The classic physical findings and laboratory data . . .
Create a clinical chief executive role in hospitals
Authors: J. Fabre
Journal: BMJ (2015)

The NHS remains an admirable institution but is in decline. A root cause of the malaise is the absence of a national clinical leadership structure, interestingly from its inception.

If I ruled the NHS I would begin by establishing a clinically strong NHS England board. Currently, only four of 17 board members have a medical or nursing background. I would ask nine of the medical royal colleges to put forward one nominee each and the Royal College of Nursing two nominees (excluding current members of their councils) to join as executive directors. In addition, two clinical chief executives and two …
NCI Reauthorization Decisions Postponed
Authors: D. A. Tisevich
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article NCI Reauthorization Decisions Postponed Get access Dorothy A. Tisevich Dorothy A. Tisevich Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 24, 19 December 1990, Pages 1875–1876, https://doi.org/10.1093/jnci/82.24.1875 Published: 19 December 1990
Why Sepsis Trials Fail
Authors: Roger C. Bone
Journal: JAMA (1996)

FEW CRITICAL conditions in medicine are as paradoxical as the events occurring during sepsis. The response of the patient's body to an insult such as infection or severe injury may initially be appropriate, but such defenses can lose their usual balance and destroy the patient. If the defense forces could be down-regulated after they have responded to the initial insult but before they begin destroying the body itself, we could prevent sepsis from developing—or at least reduce the associated mortality. Deceptively simple, a viable way to accomplish this downregulation has eluded intense clinical research scrutiny for more than 10 years. All the trials of new therapies for sepsis conducted to date have failed to show efficacy (Table). Conducted under the rigorous conditions of the double-blind, randomized, placebo-controlled trial, their uniformly negative results have provoked great disappointment. I believe the trials have reached the correct conclusion. The problem has not been
Points: Conjunctivitis and practolol
Authors: K W Lovel
Journal: BMJ (1980)

Hyperlipidaemia advances and retreatsDr A LEWIS (London WlN 1FJ) writes: How long will it be before the hazards of eating dairy foods (23 August, p 564) are remembered with amusement like those of eating meat.This dangerous stuff (especially red meat) "caused" kidney disease, hypertension, rheumatism, and gout because it was a source of uric acid and urea, with which these conditions were thought to be associated. Drugs and rheumatoid arthritisDr JACK BOURNE (Hornchurch, Essex) writes: In his letter on the effect of corticosteroids on the manifestations of rheumatoid arthritis,
480 ANTIVIRAL THERAPY CAN LEAD TO FIBROSIS REGRESSION IN ANTIHBE-POSITIVE CHRONIC HEPATITIS B PATIENTS TREATED IN CLINICAL PRACTICE
Authors: N. Papachrysos, P. Hytiroglou, L. Papalavrentios, E. Sinakos, I. Kouvelis, E. Akriviadis
Journal: Journal of Hepatology (2012)
Ineffectiveness of β-Carotene In Lupus Erythematosus
Authors: Edmund L. Dubois
Journal: JAMA (1976)

To the Editor.—  It is well known that the skin lesions of both discoid and systemic lupus erythematosus (LE) are frequently aggravated or precipitated by ultraviolet exposure. 1 Studieshave shown that rays primarily in the 290- to 320-nm range will aggravate or induce discoid lesions in photosensitive patients. 2 β-Carotene is a synthetic carotenoid pigment normally found in green and yellow vegetables, which is nontoxic although it stains skin and is known to reduce the photosensitivity reaction to visible light in the range of 380 to 500 nm. 3 Mathews-Roth et al 3 demonstrated that normal volunteers were protected from sunburn by the oral administration of β-carotene, and that it was effective as an oral photoprotective agent in erythropoietic protoporphyria. 4 Because photosensitivity is associated with LE, we wished to investigate the possibility that agents protective against longer wave length ultraviolet radiation might have some ameliorative effect on
1043 NON-INVASIVE DIAGNOSIS OF FIBROSIS IN NAFLD: COMBINATION OF FIBROSCAN WITH BLOOD MARKERS IS MORE ACCURATE THAN SINGLE FIBROSIS TESTS
Authors: J. Boursier, J. Vergniol, A. Guillet, J. Foucher, F. Oberti, I. Fouchard-Hubert, N. Dib, P. Cales, V. de Ledinghen
Journal: Journal of Hepatology (2012)
OBSERVATIONS CONCERNING THE PRODUCTION AND EXCRETION OF CHOLESTEROL IN MAMMALS
Authors: Sanford O. Byers, Meyer Friedman
Journal: The Journal of Experimental Medicine (1952)

Plasma cholesterol was observed to fall after release of biliary obstruction without any concurrent change in biliary excretion of cholesterol. Excision of the nerve trunks accompanying the hepatic artery did not change the degree of hypercholesteremia following biliary obstruction. No significant change in the cholesterol content of hepatic tissue occurred following biliary obstruction. Animals with gastro-intestinal systems removed exhibited no significant change in plasma cholesterol, whereas those subjected to gastro-intestinal removal plus biliary obstruction exhibited a marked hypercholesteremia. Anastomosis of the bile duct to the inferior vena cava resulted in a hypercholesteremia similar to that occurring after obstruction of the bile duct.
Ongoing Monoclonal B-Cell Proliferation Is Not Common in Gastric B-Cell Lymphoma After Combined Radiochemotherapy
Authors: Birgit Alpen, Rolf Kuse, Radzak Parwaresch, Hans Konrad Müller-Hermelink, Manfred Stolte, Andreas Neubauer
Journal: Journal of Clinical Oncology (2004)

Gastric marginal-zone B-cell lymphoma (MZBCL) of the mucosa-associated lymphoid tissue (MALT) is associated with chronic Helicobacter pylori gastritis. Stable complete remission (CR) can be induced by H pylori eradication. Whether this is paralleled by cure of the lymphoma remains unclear. Persisting monoclonal bands for immunoglobulin heavy chain variable region (VH) representing the lymphoma clone have been described in up to 50% of patients in CR. This retrospective study investigated whether this phenomenon also occurs after radiochemotherapy.Biopsy samples of 20 patients receiving chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone and irradiation were analyzed before and after therapy. Study patients had Ann Arbor stage I/II primary gastric cancer, including four cases of MZBCL of MALT type, 12 cases of diffuse large-cell lymphomas (DLCL), and four cases of mixed MALT type/DLCL. Polymerase chain reaction (PCR) for VH rearrangement was performed. Monoclonal PCR products were cloned and sequenced.Fourteen of 20 patients had a monoclonal or oligoclonal band distribution at diagnosis converted into polyclonal pattern after radiochemotherapy. Of the remaining six patients, two were lost to follow-up. One patient did not respond and died of progressive disease. PCR in this patient showed persistent B-cell clonality. In three patients, the initial PCR showed a polyclonal pattern and thus could not be evaluated during follow-up.In contrast with H pylori eradication alone, radiochemotherapy results in clearing of monoclonal cells during follow-up. This may result in better elimination of residual lymphoma cells. Further study is needed to determine whether this translates into lower risk of relapse.
Quality programs in endoscopy: for the patient, the doctor and society
Authors: Arjun Koch
Journal: Endoscopy (2015)

Colorectal cancer (CRC) is the second most common cancer in Europe and the second leading cause of cancer-related mortality [1]. It has long been established that removal of the precursor lesions – colorectal polyps – reduces the incidence of CRC and cancer-related mortality [1] [2] [3].
The Wonderful World of Dissocia
Authors: Iain McClure
Journal: BMJ (2004)

By Anthony Neilson First shown at the Royal Lyceum Theatre, Edinburgh, 1 to 4 September, and now running at the Theatre Royal, Plymouth, until 25 September Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> A nthony Neilson is one of the most talented playwrights of the vibrant British drama scene. Over the last 10 years he has delivered searingly honest, challenging works such as Penetrator, The Censor , and Stitching , which have focused firmly on the dramatists' touchstone—the primary need to engage with and, in the broadest sense of the word, entertain the audience. Expectations were therefore high this year when it was announced that Neilson would be writing the … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
THE INCIDENCE OF NEUTRALIZING ANTIBODIES FOR SWINE INFLUENZA VIRUS IN THE SERA OF HUMAN BEINGS OF DIFFERENT AGES
Authors: Richard E. Shope
Journal: The Journal of Experimental Medicine (1936)

Sera from a very high proportion of the human adults and new-born infants studied neutralized swine influenza virus; sera from children below the age of 12 years seldom exerted such an effect. The results of neutralization experiments with human sera and the virus of swine influenza have been compared with the outcome of similar tests with the virus of human influenza, and it seems evident that the presence of antibodies neutralizing swine influenza virus cannot be deemed the result of repeated exposures to the current human type of virus. From the known history of swine influenza and the similarity of its etiologic virus to that obtained from man it seems likely that the virus of swine influenza is the surviving prototype of the agent primarily responsible for the great human pandemic of 1918, as Laidlaw has already suggested. The presence in human sera of antibodies neutralizing swine influenza virus is believed to indicate a previous immunizing exposure to, or infection with, an influenza virus of the 1918 type.
False-Negative Cerebral Radionuclide Flow Study, in Brain Death, Caused by a Ventricular Drain
Authors: ANNE V. E. HANSEN, PATRICK J. M. LAVIN, EDWARD B. MOODY, MARTIN P. SANDLER
Journal: Clinical Nuclear Medicine (1993)

A radlonucllde cerebral blood flow study demonstrated normal flow in the face of clinical and electrical brain death in a patient who had a ventricular drain. After the drain became obstructed and was removed, a further radionucllde study demonstrated no flow, confirming the role of the drain in the earlier false-negative studies.
A Three-Dimensional Morphometric Study of Craniofacial Shape in Schizophrenia
Authors: Peter F. Buckley, David Dean, Fred L. Bookstein, Seungho Han, Michael Yerukhimovich, Kyoung-June Min, Beth Singer
Journal: American Journal of Psychiatry (2005)

Subtle dysmorphogenesis of the craniofacial region constitutes important corroborating evidence of the neurodevelopmental origins of schizophrenia. Advances in facial visualization now allow for three-dimensional anthropometric evaluations of potentially greater discriminatory power in examining the complex geometric relationships of facial topography.Sixty-five anthropometrically derived landmarks were identified from three-dimensional facial images collected from 14 patients with schizophrenia and 11 comparison subjects, imaged with a high-resolution, portable laser scanner.Using the Procrustes morphometric approach for shape analysis, the difference in mean shapes was highly significant, with patients exhibiting superoinferior elongation of the face.The topography of craniofacial anomalies in schizophrenia is not random and points to midline deformation.
Childhood epidermolysis bullosa acquisita with autoantibodies against the noncollagenous 1 and 2 domains of type VII collagen: case report and review of the literature
Authors: M. Mayuzumi, M. Akiyama, W. Nishie, S. Ukae, M. Abe, D. Sawamura, T. Hashimoto, H. Shimizu
Journal: British Journal of Dermatology (2006)

Journal Article Childhood epidermolysis bullosa acquisita with autoantibodies against the noncollagenous 1 and 2 domains of type VII collagen: case report and review of the literature Get access M. Mayuzumi, M. Mayuzumi Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060‐8638, JapanDermatology Search for other works by this author on: Oxford Academic Google Scholar M. Akiyama, M. Akiyama Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060‐8638, Japan Masashi Akiyama. E‐mail: akiyama@med.hokudai.ac.jp Search for other works by this author on: Oxford Academic Google Scholar W. Nishie, W. Nishie Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060‐8638, JapanDermatology Search for other works by this author on: Oxford Academic Google Scholar S. Ukae, S. Ukae Pediatrics, Sapporo Social Insurance General Hospital, Sapporo, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Abe, M. Abe Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060‐8638, Japan Search for other works by this author on: Oxford Academic Google Scholar D. Sawamura, D. Sawamura Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060‐8638, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Hashimoto, T. Hashimoto Department of Dermatology, Kurume University School of Medicine, Kurume, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Shimizu H. Shimizu Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060‐8638, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 5, 1 November 2006, Pages 1048–1052, https://doi.org/10.1111/j.1365-2133.2006.07443.x Published: 01 November 2006 Article history Accepted: 17 April 2006 Published: 01 November 2006
Late cardiotoxicity after treatment for Hodgkin lymphoma
Authors: Berthe M. P. Aleman, Alexandra W. van den Belt-Dusebout, Marie L. De Bruin, Mars B. van 't Veer, Margreet H. A. Baaijens, Jan Paul de Boer, Augustinus A. M. Hart, Willem J. Klokman, Marianne A. Kuenen, Gabey M. Ouwens, Harry Bartelink, Flora E. van Leeuwen
Journal: Blood (2006)
Medicine and war: recognizing common vulnerability of friend and foe
Authors: A. Skolnick
Journal: JAMA (1991)

ABSTRACT THE RELATION between war and medicine is an old one. Hippocrates urged that  who would become a surgeon should join an army and follow it. While military campaigns have served as schools of medicine for physicians through the ages, medicine in return has done much to restrain war's cruelty and mitigate its ravages.The ethics of the healers, who lent their services to armies, helped to temper the brutality of war. According to E. A. Vastyan (The Encylcopedia of Bioethics. New York, NY: Free Press; 1978:1695-1698), 'When wounded, enemies become brothers,' has been an axiom of the most elementary international law in all epochs. A similar recognition—that all humanity's most basic bond is a bond of common vulnerability—lies at the root of the esteem accorded the physician, the privileges granted him, and the obligations he assumes.Many ancient documents recognize the need for ethical treatment of fallen enemies. For
What Is Internal Medicine?
Authors: Michael LaCombe
Journal: Annals of Internal Medicine (1993)

On Being a Doctor1 March 1993What Is Internal Medicine?Michael LaCombe, MDMichael LaCombe, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-5-199303010-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail On internist's view of what internal medicine comprises. Or should you have had those moments of uncommon richness: the sudden intimate connection with a friend, or the birth of a child, or the irresistible impulse to thoughtfulness. (Why are they so few, these epiphanies? Is it because we get caught up with the ordinary, intending to save these special moments, yet never quite return to them? Do we get sidetracked, never to get back to that special divergence that might give life meaning?)Medicine is no different. We have our special moments in medicine, moments laced with a sense of ... Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Michael A. LaCombe, MD, Oxford Hills Internal Medicine Group, 23 Winter Street, Norway, ME 04268. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe History of Internal Medicine at Baylor University Medical Center, Part 1Women’s health and enhancing generalism in internal medicineSubspecialization in Internal Medicine: A historical review, an analysis, and proposals for changeProblems in Primary Care 1 March 1993Volume 118, Issue 5Page: 384-387KeywordsDecision makingLife expectancyMedical educationPacemakersPatient advocacyPatientsRenal diseasesResidencySub-specialty careUndergraduates Issue Published: 1 March 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Epstein-Barr Virus infection and Immunologic Dysfunction in Patients with Aqueous Tear Deficiency
Authors: Stephen C. Pflugfelder, Scheffer C.G. Tseng, Jay S. Pepose, Mary Ann Fletcher, Nancy Klimas, William Feuer
Journal: Ophthalmology (1990)

The authors tested their hypothesis that Epstein-Barr virus (EBV) infection is a risk factor for aqueous tear deficiency (ATD) by evaluating 38 ATD patients and 17 controls for serologic evidence of EBV infection. Aqueous tear deficiency was graded clinically as mild or severe. A linear trend toward elevated EBV capsid (P < 0.05) and early antigen (P < 0.001) titers was noted from control to severe ATD patients. Rubella and cytomegalovirus antibody titers were poorly correlated with EBV titers, suggesting that the elevated EBV antibodies in ATD patients were not due to nonspecific polyclonal B-cell activation. Epstein-Barr virus antigens were detected in two of six lacrimal gland biopsies from severe ATD patients with Sjogren's syndrome, but in none of the control glands. Aqueous tear deficiency patients were evaluated for immunologic dysfunction associated with EBV infection. Linear trends of elevated serum IgG (P < 0.05), autoantibody and immune complex positivity (P < 0.05), and reduced natural killer cell cytotoxicity (P < 0.05) were found from controls to severe ATD patients. Furthermore, reduced T-helper lymphocyte counts (P < 0.06) and an increased percentage of HLA-DR+ CD8 lymphocytes (P < 0.05) were observed in severe ATD patients compared with the mild and control groups. A multivariate analysis of the data showed a significant correlation between severe ATD and elevated EBV early antigen titers, Sjogren's syndrome, and an increased percentage of HLA-DR+ CD8 lymphocytes. The authors' findings suggest that EBV infection may be a risk factor for development of ATD in a subset of ATD patients with greater disease severity, Sj6gren's syndrome, and immunologic dysfunction.
Comparison of Weight-Loss Diets
Authors: William J. McCarthy, Tony Kuo
Journal: JAMA (2007)

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