tbuckley/cabot-search huggingface dataset:
PWE-126 Telaprevir With Adjusted dose of Ribavirin in Naive Chc-G1: Efficacy and Treatment in Chc In Hemodialysis Population. Target C (Rct): Abstract PWE-126 Table
Authors: P Basu, N J Shah, S Farhat, R Siriki, K Mittimanj, M Rahaman, S Atluri
Journal: Gut (2013)

<h3>Introduction</h3> Chronic hepatitis C (CHC) in Hemodialysis population is 3%. Standard of care (SOC) offers reduced dose of Peg IFN Alfa (p-IFNα) and reduced Ribavirin doses eliciting sub optimal SVR of 27%. Morbidity and mortality of CHC has impact on liver kidney transplant and graft failure. Triple therapy is SOC in CHC. Telaprevir is not cleared renally and hence is safe in dialysis population. This study evaluated the triple therapy in naïve CHC-G1 in hemodialysis in Respond Guided Therapy (RGT) <h3>Methods</h3> Thirty five patients (n = 35) naïve CHC-G1 were recruited. Group A-(n = 18): p-IFNα 135 mcg once weekly, Telaprevir 750 mg two tablets-TID four days and three tablets BID post dialysis for three days; along with RBV 400 mg daily for 12 weeks followed by p-IFNα 135mcg plus RVB 400 mg till 24 weeks Group B-(n = 17) p-IFNα 135 mcg once weekly with Telaprevir same as Group A with RBV 200 mg for 12 weeks followed by p-IFNα 135mcg with RBV 400 mg till 48 weeks. Viral load to follow RGT. <h3>Results</h3> <h3>Conclusion</h3> This study demonstrates higher SVR comparing traditional SOC on hemodialysis CHC-G1 patients. Extended 48 weeks had no benefits. Multi-centre trials to follow. <h3>Disclosure of Interest</h3> None Declared.
Corrigendum to ‘Administration of the cyclic peptide COR‐1 in humans (phase I study): <i>ex vivo</i> measurements of anti‐b<sub>1</sub>‐adrenergic receptor antibody neutralization and of immune parameters’ [Eur J Heart Fail 2012;14:1230–1239]
Authors: Götz Münch, Valerie Boivin‐Jahns, Hans‐Peter Holthoff, Kristin Adler, Mariola Lappo, Stephan Truöl, Heidrun Degen, Nina Steiger, Martin J. Lohse, Roland Jahns, Martin Ungerer
Journal: European Journal of Heart Failure (2013)
Oral Therapy for Multiple Sclerosis — Sea Change or Incremental Step?
Authors: William M. Carroll
Journal: New England Journal of Medicine (2010)

The long-awaited arrival of oral formulations for the treatment of relapsing–remitting multiple sclerosis is welcome news for the estimated 2.5 million people worldwide who have this chronic, disabling disease. Since the publication of the first pivotal trial of interferon beta-1b in 1993,1 practitioners and patients alike have been anticipating the approval of oral therapies because of the relative ease of administration, which should improve adherence and reduce restrictions on lifestyle.In this issue of the Journal, researchers report the results of three well-conducted trials of the first two oral agents, cladribine and fingolimod, in the treatment of multiple sclerosis. The . . .
Delirium Admissions in Dementia
Authors: Paul J. Regal
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Permanent neurological complications in patients with thrombotic thrombocytopenic purpura
Authors: Dina Ben‐Yehuda, Michal Rose, Yossef Michaeli, Amiram Eldor
Journal: American Journal of Hematology (1988)

Abstract According to previous clinical studies, the neurological manifestations observed in patients with thrombotic thrombocytopenic purpura (TTP) are considered to be transient. The introduction of plasma therapy in 1977 as major treatment modality for TTP has changed the prognosis of the disease. In a clinical survey of 38 patients with TTP who received plasma therapy, we have observed five patients who developed permanent neurological deficits despite their prompt recovery from TTP. In this study, we describe the new complication of TTP and summarize the neurological manifestations observed in these patients during their first episode of TTP and during the relapses, which occurred in 12 of them.
Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells
Authors: Xueqing Liang, E. Ashley Moseman, Michael A. Farrar, Veronika Bachanova, Daniel J. Weisdorf, Bruce R. Blazar, Wei Chen
Journal: Blood (2010)
Notch Signaling Regulates Smooth Muscle Differentiation of Epicardium-Derived Cells
Authors: Thomas Grieskamp, Carsten Rudat, Timo H.-W. Lüdtke, Julia Norden, Andreas Kispert
Journal: Circulation Research (2011)

Rationale: The embryonic epicardium plays a crucial role in the formation of the coronary vasculature and in myocardial development, yet the exact contribution of epicardium-derived cells (EPDCs) to the vascular and connective tissue of the heart, and the factors that regulate epicardial differentiation, are insufficiently understood. Objective: To define the role of Notch signaling in murine epicardial development. Methods and Results: Using in situ hybridization and RT-PCR analyses, we detected expression of a number of Notch receptor and ligand genes in early epicardial development, as well as during formation of coronary arteries. Mice with epicardial deletion of Rbpj , the unique intracellular mediator of Notch signaling, survived to adulthood and exhibited enlarged coronary venous and arterial beds. Using a Tbx18 -based genetic lineage tracing system, we show that EPDCs give rise to fibroblasts and coronary smooth muscle cells (SMCs) but not to endothelial cells in the wild type, whereas in Rbpj -deficient embryos EPDCs form and surround the developing arteries but fail to differentiate into SMCs. Conditional activation of Notch signaling results in premature SMC differentiation of epicardial cells and prevents coronary angiogenesis. We further show that Notch signaling regulates, and cooperates with transforming growth factor β signaling in SM differentiation of EPDCs. Conclusions: Notch signaling is a crucial regulator of SM differentiation of EPDCs, and thus, of formation of a functional coronary system.
Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation
Authors: Daisuke Kurotaki, Naoki Osato, Akira Nishiyama, Michio Yamamoto, Tatsuma Ban, Hideaki Sato, Jun Nakabayashi, Marina Umehara, Noriko Miyake, Naomichi Matsumoto, Masatoshi Nakazawa, Keiko Ozato, Tomohiko Tamura
Journal: Blood (2013)
Dislocation of the Wrist
Authors: F. G. Hamilton
Journal: BMJ (1880)

promises, interesting results.At the preserat time, our experiments seem, to sh ow that this juice will not emulsify fat.It acts more slowly upon albuminoids than the gastric juice, but very rapidly converts starch-, paste.We hope to be able to separate the peculiar ferment more com- pletely from the tissues, and then to study its reactions more thoroughly.
Long-term follow-up of photodynamic therapy with BF-200 ALA and methyl aminolaevulinate for the treatment of actinic keratosis
Authors: P. Babilas
Journal: British Journal of Dermatology (2013)

Journal Article Long‐term follow‐up of photodynamic therapy with BF‐200 ALA and methyl aminolaevulinate for the treatment of actinic keratosis Get access P. Babilas P. Babilas Department of Dermatology, Regensburg University Hospital, Franz‐Josef‐Strauss‐Allee 11, D‐93053 Regensburg, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 4, 1 April 2013, Pages 686–687, https://doi.org/10.1111/bjd.12246 Published: 01 April 2013
SELECTION WITH THE MAGNET AND CULTIVATION OF RETICULO-ENDOTHELIAL CELLS (KUPFFER CELLS)
Authors: Peyton Rous, J. W. Beard
Journal: The Journal of Experimental Medicine (1934)

Methods and apparatus are described where with living Kupffer cells can be procured from the liver of the rabbit and the dog for study and cultivation in vitro. Almost none of these cells can be dislodged from the normal liver by forcible perfusion; but after they have taken up finely particulate matter (India ink, iron oxide), they come away in great numbers. When they have phagocyted ferromagnetic iron oxide they can be selected with a magnet from amongst the blood elements present in suspension with them; and they are obtainable in quantity by this means. They do poorly when plated in a thin plasma clot, failing to multiply or to assume their characteristic shape; but they flourish when allowed to attach themselves to strands of lens paper bathed in serum that is frequently changed. Bacterial infection of serum cultures of Kupffer cells from normal rabbits and dogs occurs only as the result of secondary contamination of the materials, whereas it regularly develops in cultures from animals with fever induced by the injection of nucleic acid or of killed B. prodigiosus. Kupffer cells obtained under such conditions are abnormally active, and some can be washed out of the liver of sick animals in the absence of any preliminary phagocytosis of particulate matter. The facts have a bearing both on the conditions conducing to blood invasion and on the response of the Kupffer cells in the emergency. The characters of the isolated Kupffer cells and the results of tests of their presumptive functions will be described in later papers.
Tc-99m Sestamibi and In-111 Pentetreotide Uptake in Metastatic Papillary Thyroid Carcinoma
Authors: JOHN LEE, JOHAN A. CUTRONE, CAROL S. MARCUS
Journal: Clinical Nuclear Medicine (1995)

Approximately 25% of metastatic and recurrent differentiated (papillary and follicular) thyroid carcinoma do not concentrate I-131 Nal. In such cases, diagnosis can be attempted with other radiopharmaceuticals. The authors present a case of recurrent papillary thyroid carcinoma that was well visualized with Tc-99m sestamibi and ln-111 pentetreotide; but only poorly visualized by I-131 Nal.
Immunological Aspects of Reproduction.
Authors: Seymour Katsh
Journal: Annals of Internal Medicine (1964)

s1 April 1964Immunological Aspects of Reproduction.Seymour Katsh, Ph.D.Seymour Katsh, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-732_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptControl of fertility and correction of infertility are two of many urgent problems in reproductive biology. While an attack upon these problems may be classified as applied research, solutions depend upon revealing fundamental biological mechanisms. Therefore, studies on the participation of immunological and immunochemical events relative to reproduction are being pursued. As a result of such studies, it is possible to provide experimental models of clinically observed infertile cases. For example, immunization with antigens extracted from homologous testes and spermatozoa can elicit the following spectrum of responses in recipient male guinea pigs: oligospermia, azospermia, immobilization and agglutination of spermatozoa and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Seymour Katsh, Ph.D.Affiliations: Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 732-732KeywordsAntigensGuinea pigsInfertilityTestes ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
Recording, Interpreting, and Updating the Family History of Cancer
Authors: Louise S. Acheson
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stump, "Phantom" Pain Differ
Authors: Brian Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
[121] IN EXPERIMENTAL PREASCITIC LIVER CIRRHOSIS CALCIUM-DEPENDENT DIURETIC SYSTEMS ARE DOWNREGULATED, BUT MAY BE NORMALIZED BY SPECIFIC METABOLIC AND PHARMACOLOGIC STIMULI
Authors: G. Sansoe, M. Aragno, F. Wong, F. Rosina, A. Smedile, M. Rizzetto
Journal: Journal of Hepatology (2007)
Retinoblastoma Pathway Defects Show Differential Ability to Activate the Constitutive DNA Damage Response in Human Tumorigenesis
Authors: Frederic Tort, Jirina Bartkova, Maxwell Sehested, Torben Ørntoft, Jiri Lukas, Jiri Bartek
Journal: Cancer Research (2006)

Abstract Loss of G1-S control and aberrations of the p16Ink4a-cyclin D1/cyclin-dependent kinase (CDK) 4(6)-pRb-E2F-cyclin E/CDK2 pathway are common in human cancer. Previous studies showed that oncogene-induced aberrant proliferation, such as on cyclin E overexpression, causes DNA damage and checkpoint activation. Here, we show that, in a series of human colorectal adenomas, those with deregulation of cyclin D1 and/or p16Ink4a showed little evidence of constitutive DNA damage response (DDR), contrary to cyclin E-overexpressing higher-grade cases. These observations were consistent with diverse cell culture models with differential defects of retinoblastoma pathway components, as overexpression of cyclin D1 or lack of p16Ink4a, either alone or combined, did not elicit detectable DDR. In contrast, inactivation of pRb, the key component of the pathway, activated the DDR in cultured human or mouse cells, analogous to elevated cyclin E. These results highlight differential effect of diverse oncogenic events on driving the ‘cancer cell cycles’ and their ability to deregulate the replication-driving CDK2 kinase and to alarm the DDR as a potential anticancer barrier in accordance with their hierarchical positions along the retinoblastoma pathway. Our data provide new insights into oncogene-evoked DDR in human tumorigenesis, with potential implications for individualized management of tumors with elevated cyclin D1 versus cyclin E, due to their distinct clinical variables and biological behavior. (Cancer Res 2006; 66(21): 10258-63)
Immunohistochemical study of angiotensin receptors in normal human sweat glands and eccrine poroma
Authors: H. Takeda, S. Kondo
Journal: British Journal of Dermatology (2001)

Angiotensin II exerts its actions through its specific receptors. However, expression of these receptors has not been determined in sweat glands.To clarify the expression and localization of the angiotensin receptors in normal human sweat glands and eccrine poroma.Expression of angiotensin type 1 (AT1) and type 2 (AT2) receptors in normal human eccrine and apocrine sweat glands and 12 cases of eccrine poroma was studied using immunohistochemistry.In eccrine sweat glands, the acrosyringium and the inner surfaces and luminal cells of the intradermal duct showed positive staining with AT1. In apocrine sweat glands, the intraepithelial duct and luminal cells of the intradermal duct showed positive staining with AT1. In 12 cases of eccrine poroma, some of the tumour cells in the tumour strands and cells surrounding the luminal structures stained positively. There were no positive findings with AT2.Studying AT1 distribution may be useful in understanding the pathophysiology of sweat glands and sweat gland tumours.
Host-parasite relationships in hyperkeratotic (Norwegian) scabies: pathological and immunological findings
Authors: D. NESTE, J.M. LACHAPELLE
Journal: British Journal of Dermatology (1981)

The dynamics of intraepidermal penetration of the scabies mite and the host's responses to the invaders have been studied in hyperkeratotic scabies. Contrary to the generally accepted view, the mites progressed not only through the stratum corneum but also into the underlying epidermis and even occasionally to the dermo-epidermal interface. Morphological evidence of reactive processes included parakeratosis surrounding the burrows, psoriasiform hyperplasia with increased basal cell labelling indices and exocytosis of mononuclear cells. 3H-Thymidine labelling indices of immunocompetent cells of the dermal infiltrate reached levels found in allergic patch test reactions and were in both cases higher than in non-immune-specific inflammatory processes. The labelling index of peripheral blood lymphocytes showed an increased ratio of B cells to T cells as compared to controls or patients with allergic contact dermatitis. Serum C1q fixation was higher than in untreated patients with common scabies. These results support our previous findings of immunological activation in hosts infested by the scabies mite.
925-41 Coronary Sinus pH During Dipyridamole Infusion in Patients with Angina and Hypertrophic Cardiomyopathy
Authors: Perry M. Elliott, Giuseppe M.C. Rosano, Jaswinder Gill, Juan Carlos Kaski, Philip A. Poole-Wilson, William J. McKenna
Journal: Journal of the American College of Cardiology (1995)
"Smart" rationing is possible
Authors: S. Goldbeck-Wood
Journal: BMJ (1997)

The barriers to fair rationing are fewer than we think, according to Dr David Eddy, senior adviser for health policy and management at Kaiser Permanente, a large managed care organisation in the United States.

Addressing a conference in London, Rationing in the NHS: Time to Get Real , Dr Eddy said that rationing has always taken place in all healthcare systems, but what we currently have in the NHS is “dumb rationing.”

The conference, which was attended by 250 delegates, was organised by the BMA, the King's Fund, the College of Health, and …
GluN2B in corticostriatal circuits governs choice learning and choice shifting
Authors: Jonathan L Brigman, Rachel A Daut, Tara Wright, Ozge Gunduz-Cinar, Carolyn Graybeal, Margaret I Davis, Zhihong Jiang, Lisa M Saksida, Seiichiro Jinde, Matthew Pease, Timothy J Bussey, David M Lovinger, Kazu Nakazawa, Andrew Holmes
Journal: Nature Neuroscience (2013)
Pan-American Medical Congress, and the Journal.
Authors: P. C. Coleman
Journal: JAMA (1895)

Colorado, Texas, Oct. 30, 1895. <h3>To the Editor:</h3> —I see inJournaljust received, notice of " Transactions of the First Pan-American Medical Congress" recently published. I was a member of the Congress from Texas, and paid $10 dues. Am I entitled to copy, because of this fact, or will I have to buy it? I congratulate you on your signal success in the management of theJournal. It is now in every respect the equal of any published, and may you stay with it. Very truly yours, <h3>Answer:</h3> —The copy reviewed by theJournalwas an advance copy sent by President Pepper for notice. We have no doubt the members will receive their copies in regular course of distribution. Thanks for words of encouragement.
Treating Child and Adolescent Depression
Authors: Brenda Bursch
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Another frame shift: From cultural transmission to cultural co-construction
Authors: Barbara J. King
Journal: Behavioral and Brain Sciences (2000)

Laland et al.'s bidirectional model is a welcome starting point that can be enhanced by a full incorporation of systems thinking into its framework. Systems thinkers note that culture is not transmitted linearly in chunks but is co-constructed within subgroups. Niche construction, particularly among primates, should be studied primarily through the effects that social relationships have on selection pressures.