tbuckley/cabot-search huggingface dataset:
PRESSOR SUBSTANCES IN ARTERIAL HYPERTENSION
Authors: Henry A. Schroeder, H. Mitchell Perry, Evie G. Dennis, Laura E. Mahoney
Journal: The Journal of Experimental Medicine (1955)

Some pharmacological and chemical qualities of pherentasin, a vasoconstrictor substance procured from human hypertensive blood, were studied by a new assay method using the spirally cut rabbit aorta. Of a number of drugs tested, six metal-binding agents including hydralazine inactivated the active principle. The material was stable in acid but not in alkali. It was destroyed by drying. Chemical analysis and inactivation procedures suggested the presence of primary amine and considerable sulfur; a peptide linkage was suspected because of inactivation by manganous ion and papain. The material was remarkably resistant to most pharmacological agents and appeared to act directly on smooth muscle.
A Phase II, Open-Label Study of Ramucirumab in Combination with Paclitaxel and Carboplatin as First-Line Therapy in Patients with Stage IIIB/IV Non–Small-Cell Lung Cancer
Authors: D. Ross Camidge, Eamon M. Berge, Robert C. Doebele, Marc S. Ballas, Thierry Jahan, Missak Haigentz, David Hoffman, James Spicer, Howard West, Pablo Lee, Ling Yang, Adarsh Joshi, Ling Gao, Sergey Yurasov, Alain Mita
Journal: Journal of Thoracic Oncology (2014)

The objective of this study was to determine whether the addition of ramucirumab to first-line paclitaxel-carboplatin chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC) resulted in a 6-month progression-free survival (PFS) rate that compares favorably with the historic rate for bevacizumab combined with paclitaxel-carboplatin in this patient population.In this phase II, single-arm, open-label, multicenter study, 40 patients with advanced NSCLC received ramucirumab (10 mg/kg intravenous [IV]) followed by paclitaxel (200 mg/m IV) and carboplatin area under the curve = 6 on day 1 every 21 days as first-line therapy. Therapy continued for up to six cycles. Patients not experiencing withdrawal criteria may have continued ramucirumab monotherapy every 3 weeks. The primary endpoint was PFS at 6 months, with 80% power to detect a 6-month PFS rate of at least 55%.The 6-month PFS rate was 59.0% and the objective response rate was 55.0%. The most common treatment-related adverse events were fatigue, peripheral neuropathy, nausea, epistaxis, and myalgia. Single-nucleotide polymorphism (SNP) rs2981582 on the FGFR-2gene had significant associations with improved overall survival, PFS, and best overall response (p values without multiplicity adjustment were 0.0059, 0.0429, and 0.0392, respectively).Ramucirumab in combination with paclitaxel-carboplatin resulted in a 6-month PFS rate and safety profile that compared favorably with the historical control. In addition, no deaths were associated with this treatment. Furthermore, we describe an association of SNP on FGFR-2 gene with survival and response. These findings warrant further clinical investigation in patients with NSCLC.
PROTEIN-LIPID RELATIONSHIPS IN HUMAN PLASMA: IN BILIARY CIRRHOSIS, OBSTRUCTIVE JAUNDICE, AND ACUTE HEPATITIS 1
Authors: Howard A. Eder, Ella M. Russ, R. A. Rees Pritchett, Mary M. Wilber, David P. Barr
Journal: Journal of Clinical Investigation (1955)

In 1862, Austin Flint (1) found that cholesterol accumulated in the blood in obstructive jaundice.
The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production
Authors: Hiroki Yoshida, Hiroshi Nishina, Hiroaki Takimoto, Luc E.M Marengère, Andrew C Wakeham, Denis Bouchard, Young-Yun Kong, Toshiaki Ohteki, Arda Shahinian, Martin Bachmann, Pamela S Ohashi, Josef M Penninger, Gerald R Crabtree, Tak W Mak
Journal: Immunity (1998)
Transpleural Complications of Liver Biopsy
Authors: HAROLD O. CONN
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 July 1972Transpleural Complications of Liver BiopsyHAROLD O. CONN, M.D.HAROLD O. CONN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-1-154_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Since submitting my manuscript on unilateral edema (1), I have encountered a cirrhotic patient with ascites who developed unilateral right-sided edema after a liver biopsy. The transthoracic biopsy had been done with a Klatskin modification of the Menghini needle in the 9th intercostal space without incident. Three days later the patient had fever, cough, and dullness at the base of the right hemithorax, presumed to be a pleural effusion. The right diaphragm moved normally. There was dependent unilateral edema of the right chest and abdomen that extended down to the crest of the ilium. The liver biopsy...Reference1. CONN H: Unilateral edema and jaundice after portacaval anastomosis. Ann Intern Med 76:459-461, 1972 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1972Volume 77, Issue 1Page: 154-154KeywordsAscitesBiopsyEdemaFeversLiverPatient advocacyPleural effusionThorax Issue Published: 1 July 1972 PDF DownloadLoading ...
Animal models may help fractionate shared and discrete pathways underpinning schizophrenia and autism
Authors: Thomas H. J. Burne, Darryl W. Eyles, John J. McGrath
Journal: Behavioral and Brain Sciences (2008)

Abstract Crespi &amp; Badcock (C&amp;B) present an appealing and parsimonious synthesis arguing that schizophrenia and autism are differentially regulated by maternal versus paternal genomic imprinting, respectively. We argue that animal models related to schizophrenia and autism provide a useful platform to explore the mechanisms outlined by C&amp;B. We also note that schizophrenia and autism share certain risk factors such as advanced paternal age. Apart from genomic imprinting, copy number variants related to advanced paternal age may also contribute to the differential trajectory of brain development associated with autism and schizophrenia.
Families at risk of genetically high cholesterol are not being spotted, says royal college
Authors: H. Mooney
Journal: BMJ (2011)

The NHS is failing to diagnose thousands of cases of the genetic heart condition familial hypercholesterolaemia, which if diagnosed early enough can be successfully managed, the Royal College of Physicians has warned.

An audit carried out by the college’s clinical standards department shows that about 120 000 people in the United Kingdom are at risk from the inherited condition, which causes high concentrations of LDL cholesterol and early heart disease.

The report shows that around half of men with familial hypercholesterolaemia, if untreated, will have developed heart disease by the age …
(4) Actinic reticuloid: is it pre-malignant?
Authors: P.G. Norris, J.A. Newton, R. Camplejohn, N.P. Smith, J.L.M. Hawk
Journal: British Journal of Dermatology (1987)

Journal Article (4) Actinic reticuloid: is it pre‐malignant? Get access P.G. Norris, P.G. Norris Institute of Dermatology, St Thomas's Hospital, London SE17EH Search for other works by this author on: Oxford Academic Google Scholar J.A. Newton, J.A. Newton Institute of Dermatology, St Thomas's Hospital, London SE17EHRichard Dimbleby Cancer Research Department, St Thomas's Hospital, London SE17EH Search for other works by this author on: Oxford Academic Google Scholar R. Camplejohn, R. Camplejohn Richard Dimbleby Cancer Research Department, St Thomas's Hospital, London SE17EH Search for other works by this author on: Oxford Academic Google Scholar N.P. Smith, N.P. Smith Institute of Dermatology, St Thomas's Hospital, London SE17EH Search for other works by this author on: Oxford Academic Google Scholar J.L.M. Hawk J.L.M. Hawk Institute of Dermatology, St Thomas's Hospital, London SE17EH Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Page 33, https://doi.org/10.1111/j.1365-2133.1987.tb12022.x Published: 01 June 1987
Blood Flow Dynamics in Heart Failure
Authors: J. Kevin Shoemaker, Heather L. Naylor, Cynthia S. Hogeman, Lawrence I. Sinoway
Journal: Circulation (1999)

Exercise intolerance in heart failure (HF) may be due to inadequate vasodilation, augmented vasoconstriction, and/or altered muscle metabolic responses that lead to fatigue.Vascular and metabolic responses to rhythmic forearm exercise were tested in 9 HF patients and 9 control subjects (CTL) during 2 protocols designed to examine the effect of HF on the time course of oxygen delivery versus uptake (protocol 1) and on vasoconstriction during exercise with 50 mm Hg pressure about the forearm to evoke a metaboreflex (protocol 2). In protocol 1, venous lactate and H+ were greater at 4 minutes of exercise in HF versus CTL (P<0.05) despite similar blood flow and oxygen uptake responses. In protocol 2, mean arterial pressure increased similarly in each group during ischemic exercise. In CTL, forearm blood flow and vascular conductance were similar at the end of ischemic and ambient exercise. In HF, forearm blood flow and vascular conductance were reduced during ischemic exercise compared with the ambient trial.Intrinsic differences in skeletal muscle metabolism, not vasodilatory dynamics, must account for the augmented glycolytic metabolic responses to moderate-intensity exercise in class II and III HF. The inability to increase forearm vascular conductance during ischemic handgrip exercise, despite a normal pressor response, suggests that enhanced vasoconstriction of strenuously exercising skeletal muscle contributes to exertional fatigue in HF.
113. Transduction of Neural Cells in Primate Brain Using Adeno-Associated Virus (AAV) Serotypes 2 and 5
Authors: Eleni A. Markakis, Csaba Leranth, Jeremy Bober, R. Jude Samulski, J.E. Rabinowitz, X. Zhou, Kenneth Vives, D. Eugene Redmond, Jr
Journal: Molecular Therapy (2006)

Top of pageAbstract
There are currently eleven identified serotypes of the adenoassociated virus (AAV), a single stranded DNA parvovirus used extensively for gene delivery in animals; yet AAV serotype 2, the first to be characterized, is the most widely used for gene delivery. While homology exists among most serotypes, considerable differences in the viral capsid surface have been described for AAV4, and AAV5, which are believed to have greater tropism for cells in the central nervous system than other serotypes of AAV. To test the relative efficiency with which vectors made from AAV2, and AAV5 can transduce cells of the primate central nervous system, we injected the brains of St. Kitts green monkeys with viral vectors of both serotypes, each expressing the reporter gene green fluorescent protein (GFP). The vectors were all of comparable titer, injected in equal amounts in positive pressure, stereotaxic injections using the same rate of infusion into the substantia nigra. Animals were perfused after a one month survival, and their brains removed and sectioned. One series of sections was stained with the antibody to GFP using a diaminobenzidine (DAB) secondary reaction. These DAB sections were counted under a light microscope using a computer equipped with software for unbiased stereology, and counts for labeled cells were made. Remaining adjacent series of sections were processed for immunohistochemistry for glial fibrillary acidic protein (GFAP), an intermediate filament protein that labels cells of astroglial lineage, or neurofilament (NF), three intermediate filament proteins that are structural components of neurons and their axons. Sections were reacted with fluorescent secondary antibodies, the inherent fluorescence of GFP remaining unreacted, and the sections were examined using confocal laser scanning microscopy. Counts made for numbers of transduced cells using unbiased stereology show that AAV5 transduced a greater number of cells in the central nervous system than did AAV2. Furthermore, AAV5 transduced GFAP positive glial cells with notable preference over NF-positive neurons. This preference presages a role for AAV5 in cell supportive, or cell replacement strategies, as transduced glial cells mat be induced to produce neuron supportive gene products, such as GDNF, in a more physiological and sustainable fashion than can neurons.
STUDIES ON CHEYNE-STOKES RESPIRATION
Authors: Albert J. Anthony, Alfred E. Cohn, J. Murray Steele
Journal: Journal of Clinical Investigation (1932)

Cheyne-Stokes respiration is characterized by rhythmic changes in breathing in which periods of respiratory pause alternate with periods of slowly increasing and decreasing respiratory activity.It may be accompanied by phasic variations in the functions of the heart, nervous system and other organs, and has more recently been found to be asso- ciated with periodic variation in the concentration of the gases in the blood.It occurs as a symptom in diseases of the heart and kidneys especially, in meningitis and in encephalitis, and in certain intoxications such as morphine poisoning and oxygen lack.The development of this type of breathing has been ascribed to many causes-disturbances in the gaseous exchange in the lungs, of the circulation, of the activity of the respiratory and vasomotor centers and to so-called sub-cortical influences.Objections to all these hypotheses have been entered with the result that no satisfactory understanding of the subject has been attained.It is of value, therefore, to record further observations of Cheyne-Stokes respiration and its attendant or resultant phenomena.The phenomenon concerning which it seems now important to accum- ulate more experience, is the behavior of the gases, carbon dioxide and oxygen, in the blood under the circumstances which attend this type of respiration.For this purpose, samples of arterial blood taken from patients exhibiting this abnormality were studied.A few analyses of arterial blood have already been reported by Gollwitzer-Meier (1), Uhlen- bruck (2), and Resnik and Lathrop (3).Their studies show that variations in the concentration of the gases in the blood do occur during different phases of respiration I and that at some point during the res- piratory cycle, oxygen saturation of the blood usually reaches normal limits.The average carbon dioxide content in the blood is reported in some cases to be increased, in others decreased, and in others normal.In for- mer studies only one or two samples of blood were, however, taken; but in order to ascertain the extent of the variation in the concentration of the gases in the blood during a cycle of Cheyne-Stokes respiration it is
Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: a report from the Children's Oncology Group
Authors: Smita Bhatia, Mark D. Krailo, Zhengjia Chen, Laura Burden, Frederic B. Askin, Paul S. Dickman, Holcombe E. Grier, Michael P. Link, Paul A. Meyers, Elizabeth J. Perlman, Aaron R. Rausen, Leslie L. Robison, Teresa J. Vietti, James S. Miser
Journal: Blood (2006)
Evidence based cardiology: Prevention of congestive heart failure and management of asymptomatic left ventricular dysfunction
Authors: R S McKelvie, C R Benedict, S Yusuf
Journal: BMJ (1999)

This is the second of four articles

The epidemiology of heart failure has been studied largely among symptomatic individuals because identification of these patients is based on clinical criteria and does not require measuring left ventricular function.1 However, identifying people who are at high risk of heart failure could lead to the implementation of strategies that could potentially prevent heart failure and improve prognosis. This article reviews the prevalence of left ventricular dysfunction, the management of asymptomatic left ventricular dysfunction, and the prevention of heart failure.

### Summary points

The data on the prevalence of asymptomatic left ventricular dysfunction are limited, even though treatment of patients with this condition may be expected to improve their outcome.2–3 In 1992 McDonagh et al measured ejection fraction in 1467 people during a survey of coronary risk factors.3 The mean ejection fraction was 47% among people defined as not having cardiovascular disease, and 34% was two standard deviations below the mean. Of the 2.9% with an ejection fraction of 30%, half had no symptoms. The frequency of both left ventricular dysfunction and symptoms was greater in older age groups, increasing sharply up to the age of 45 and less sharply thereafter (table 1). Of the 7.7% with an ejection fraction of 35%, 77% were asymptomatic. Of those with definite left ventricular dysfunction (table 1), the proportion with symptoms increased with age. The group with left ventricular dysfunction had a greater prevalence of ischaemic heart …
Malnutrition in infants receiving cult diets: a form of child abuse.
Authors: I F Roberts, R J West, D Ogilvie, M J Dillon
Journal: BMJ (1979)

Severe nutritional disorders, including kwashiorkor, marasmus, and rickets, were seen in four children and were due to parental food faddism, which should perhaps be regarded as a form of child abuse. All disorders were corrected with more normal diets and vitamin supplements. In view of the potentially serious consequences of restricted diets being fed to children, families at risk should be identified and acceptable nutritional advice given. When children are found to be suffering from undernutrition due to parental food faddism a court order will normally be a necessary step in providing adequate treatment and supervision.
Etiology of Upper-Respiratory-Tract Illnesses Among Civilian Adults
Authors: Maurice A. Mufson
Journal: JAMA (1966)

Virus infection was identified in 34% of 221 upperrespiratory-tract illnesses in adults. The single most important agents were the rhinoviruses. Rhinoviruses were recovered from 18% of 221 patients tested, and 82% of these patients had fourfold or greater rises in homologous antibody. Influenza A virus, parainfluenza virus type 1 or 3, or herpesvirus infection occurred in only 2% to 5% of patients, and infection with respiratory syncytial virus, adenovirus, parainfluenza virus type 2, and coxsackievirus A-21 occurred in less than 1% of patients. Thirty-one of the 40 rhinovirus strains could be identified serologically, and these belonged to 17 different serotypes. In this study the pattern of rhinovirus infection appeared to be that of a constantly changing mosaic involving different serotypes. No one serotype was predominant, and only six serotypes were detected more than once.
Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma
Authors: Kimberly A Kelly, Nabeel Bardeesy, Rajesh Anbazhagan, Sushma Gurumurthy, Justin Berger, Herlen Alencar, Ronald A DePinho, Umar Mahmood, Ralph Weissleder
Journal: PLoS Medicine (2008)

Background Pancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis, typically presenting with metastasis at the time of diagnosis and exhibiting profound resistance to existing therapies. The development of molecular markers and imaging probes for incipient PDAC would enable earlier detection and guide the development of interventive therapies. Here we sought to identify novel molecular markers and to test their potential as targeted imaging agents. Methods and Findings Here, a phage display approach was used in a mouse model of PDAC to screen for peptides that specifically bind to cell surface antigens on PDAC cells. These screens yielded a motif that distinguishes PDAC cells from normal pancreatic duct cells in vitro, which, upon proteomics analysis, identified plectin-1 as a novel biomarker of PDAC. To assess their utility for in vivo imaging, the plectin-1 targeted peptides (PTP) were conjugated to magnetofluorescent nanoparticles. In conjunction with intravital confocal microscopy and MRI, these nanoparticles enabled detection of small PDAC and precursor lesions in engineered mouse models. Conclusions Our approach exploited a well-defined model of PDAC, enabling rapid identification and validation of PTP. The developed specific imaging probe, along with the discovery of plectin-1 as a novel biomarker, may have clinical utility in the diagnosis and management of PDAC in humans.
Alloreactive microenvironment after human hematopoietic cell transplantation induces genomic alterations in epithelium through an ROS-mediated mechanism: in vivo and in vitro study and implications to secondary neoplasia
Authors: M Themeli, L Petrikkos, M Waterhouse, H Bertz, E Lagadinou, N Zoumbos, J Finke, A Spyridonidis
Journal: Leukemia (2010)
S4 Relationship Between Historic Uk Asbestos Imports And Annual Mortality Due To Mesothelioma, Asbestosis And Idiopathic Pulmonary Fibrosis
Authors: C. Barber, R. Wiggans, D. Fishwick
Journal: Thorax (2014)

<h3>Background</h3> Previous studies from a number of countries have demonstrated that the rising mortality due to mesothelioma and asbestosis can be predicted from their historic asbestos usage. Mortality due to idiopathic pulmonary fibrosis (IPF) is also rising in the UK, without any identified explanation. This analysis compared annual male and female mortality due to IPF, asbestosis and mesothelioma, and examined the relationship between mortality and national asbestos import data. <h3>Methods</h3> Mortality data for IPF and asbestosis in England and Wales were available from the Office for National Statistics (ONS). Data for mesothelioma deaths in England and Wales and historic UK asbestos import data were available from the Health and Safety Executive (HSE). The numbers of annual deaths due to each condition were plotted separately by gender, against UK asbestos imports 48 years earlier. Pearson correlation co-efficients were then calculated. <h3>Results</h3> Correlation co-fficients for each condition are shown in Table 1. The annual number of deaths due to mesothelioma and IPF were significantly correlated with historical asbestos imports for both genders. For asbestosis mortality, a similar relationship was found for male but not female deaths. <h3>Conclusion</h3> The strength of the association between IPF and historical asbestos imports was similar to that seen for mesothelioma mortality. This finding suggests that the role of occupational and environmental asbestos exposure in the aetiology of IPF requires further consideration.
Data Processing in Endoscopy: Endotorace, a New Software Program for Bronchoscopy Reporting
Authors: L. Trevisani, S. Sartori, S. Putinati, G. Milani, E. Fiorillo
Journal: Endoscopy (1994)

See also: Data Processing in EndoscopyEndoscopy 1992; 24(01/02): 167-168DOI: 10.1055/s-2007-1010456
Myocardial Gene Expression in Dilated Cardiomyopathy Treated with Beta-Blocking Agents
Authors: Brian D. Lowes, Edward M. Gilbert, William T. Abraham, Wayne A. Minobe, Patti Larrabee, Debra Ferguson, Eugene E. Wolfel, JoAnn Lindenfeld, Tatiana Tsvetkova, Alastair D. Robertson, Robert A. Quaife, Michael R. Bristow
Journal: New England Journal of Medicine (2002)

Beta-blocker therapy may improve cardiac function in patients with idiopathic dilated cardiomyopathy. We tested the hypothesis that beta-blocker therapy produces favorable functional effects in dilated cardiomyopathy by altering the expression of myocardial genes that regulate contractility and pathologic hypertrophy.
Multiphoton Microscopy for 3-Dimensional Imaging of Lymphocyte Recruitment Into Apolipoprotein-E–Deficient Mouse Carotid Artery
Authors: Pasquale Maffia, Bernd H. Zinselmeyer, Armando Ialenti, Simon Kennedy, Andrew H. Baker, Iain B. McInnes, James M. Brewer, Paul Garside
Journal: Circulation (2007)