tbuckley/cabot-search huggingface dataset:
Proteome-wide Quantification and Characterization of Oxidation-Sensitive Cysteines in Pathogenic Bacteria
Authors: Xin Deng, Eranthie Weerapana, Olesya Ulanovskaya, Fei Sun, Haihua Liang, Quanjiang Ji, Yan Ye, Ye Fu, Lu Zhou, Jiaxin Li, Haiyan Zhang, Chu Wang, Sophie Alvarez, Leslie M. Hicks, Lefu Lan, Min Wu, Benjamin F. Cravatt, Chuan He
Journal: Cell Host & Microbe (2013)
MIGRATION OF LYMPHOCYTES IN PLASMA CULTURES OF HUMAN LYMPH NODES
Authors: Warren H. Lewis, Leslie T. Webster
Journal: The Journal of Experimental Medicine (1921)

1. Lymphocytes were usually the first cells to migrate out into the plasmic clot from explanted pieces of lymph nodes. 2. Their paths of migration were irregular but in general they proceeded away from the explant. 3. The lymphocytes migrated at rates varying from 0.03 to 0.0013 mm. per minute. The rate of any one varied from minute to minute, and they often came to rest for varying lengths of time. 4. The migrating lymphocytes were very much elongated, with the nucleus always near the anterior end. The elongated tail contained the endoplasm with a few granular mitochondria and usually a few granules which took up neutral red. 5. The lymphocytes in cultures made from normal and pathological lymph nodes in auto and homoplasma showed no differences.
Europe-wide surveillance for sexually transmitted infections: a timely and appropriate intervention
Authors: K. A. Fenton, J Giesecke, F F Hamers
Journal: Eurosurveillance (2001)

Sexually transmitted infections (STIs), including HIV, pose a significant threat to the health and wellbeing of Europeans and require concerted and sustained intervention. Over the past decade, the number of reported cases of STIs, including antimicrobial resistant Neisseria gonorrhoeae, has increased appreciably, and outbreaks of syphilis have recently been reported in many Member states of the European Union (EU). Young people, homosexual men, and those with poor access to health care (including preventive and educational services) seem to be particularly affected, with increased travel and migration, high risk sexual behaviours, and a deterioration of public health responses to STI control (for example, partner notification) being key driving factors. Many of these demographic and behavioural trends are similar across EU states, as is the desire to develop and implement effective STI prevention and control programmes.
Is Preventing Sudden Cardiac Death Realistic?
Authors: Eduardo A. Sanchez
Journal: Annals of Internal Medicine (1994)

Letters15 May 1994Is Preventing Sudden Cardiac Death Realistic?Eduardo A. Sanchez, MDEduardo A. Sanchez, MDLawrence, NY 11559Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-10-199405150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent overview of sudden cardiac death by Myerburg and colleagues [1] was informative. However, as a general internist, I have difficulty applying this knowledge preventively.The pathophysiology of sudden cardiac death is multifactorial and complex. To be effective, prevention must be targeted at the general population.The worst outcome among survivors of a major cardiovascular event is seen in the subgroup with low ejection fractions (<30%). Because the underlying cause in most of these patients is coronary artery disease, does ultrafast computed tomography have a role in identifying coronary calcifications in the screening of these patients?... References1. Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death: epidemiology, transient risk, and intervention assessment. Ann Intern Med. 1993; 119:1187-97. Google Scholar2. Agatson AS, Janowitz WR. Coronary calcification: detection by ultrafast computed tomography. In: Stanford W, Rumberger JA, eds. Ultrafast Computed Tomography in Cardiac Imaging: Principles and Practice. Mount Kisco, New York: Futura Publishing Co.; 1992:77-95. Google Scholar3. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med. 1989; 331:406-12. Google Scholar4. Bailie DS, Inoue H, Kaseda S, Ben-David J, Zipes DP. Magnesium suppresses early after depolarizations and ventricular tachyarrhythmias induced in dogs by cesium. Circulation. 1988; 77:1395. Google Scholar Author, Article, and Disclosure InformationAuthors: Eduardo A. Sanchez, MDAffiliations: Lawrence, NY 11559 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1994Volume 120, Issue 10Page: 891-892KeywordsComputed axial tomographyCoronary arteriesEjection fractionMagnesiumStable coronary artery diseaseSudden cardiac death ePublished: 15 August 2000 Issue Published: 15 May 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Monilial granuloma in an adult, successfully treated with amphotericin B.
Authors: R. Workman Carslaw, Anne Richardson, J. Alistair Cameron
Journal: British Journal of Dermatology (1966)

Journal Article Monilial granuloma in an adult, successfully treated with amphotericin B. Get access R. Workman Carslaw, R. Workman Carslaw Victoria Infirmary, Glasgow, S.2 Search for other works by this author on: Oxford Academic Google Scholar Anne Richardson, Anne Richardson Victoria Infirmary, Glasgow, S.2 Search for other works by this author on: Oxford Academic Google Scholar J. Alistair Cameron J. Alistair Cameron Victoria Infirmary, Glasgow, S.2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 4, 1 April 1966, Pages 242–244, https://doi.org/10.1111/j.1365-2133.1966.tb12214.x Published: 01 April 1966
Functional 2:1 A-V Block within the His-Purkinje System
Authors: ANTHONY N. DAMATO, P. JACOB VARGHESE, ANTHONY R. CARACTA, MASOOD AKHTAR, SUN H. LAU
Journal: Circulation (1973)

In eight subjects in whom the effective refractory period of the His-Purkinje system was determined to be longer than that of the A-V node or atrium, abrupt acceleration of the atrial rate resulted in either 2:1 block within the His-Purkinje system or 1:1 A-V conduction. The former conduction pattern simulated a type II second-degree A-V block. The occurrence of either 2:1 block within the His-Purkinje system or 1:1 A-V conduction was determined primarily by (1) an effective refractory period of the His-Purkinje system which exceeded that of the A-V node, (2) the coupling interval of the first atrial capture beat and its effect or lack thereof on the refractory period of His-Purkinje system as it relates to changes in ventricular cycle length, and (3) the relative speed of A-V nodal conduction time. The distinction between this functional 2:1 block within the His-Purkinje system and a true type II second-degree block is discussed from both the clinical and electrophysiologic points of view. Functional 2:1 block within the His-Purkinje can also result when sudden acceleration of atrial rate occurs spontaneously such as in atrial flutter or A-V nodal reentrant atrial tachycardias.
Home Blood-Pressure Monitoring in Patients Receiving Sunitinib
Authors: Michel Azizi, Antoine Chedid, Stéphane Oudard
Journal: New England Journal of Medicine (2008)

To the Editor: The use of sunitinib, an inhibitor of the split-kinase-domain family of receptor tyrosine kinases (including vascular endothelial growth factor receptor types 1 and 21), has been ass...
Pilot study of the combination of interferon alfa and ribavirin as therapy of recurrent hepatitis C after liver transplantation
Authors: T Bizollon, U Palazzo, C Ducerf, M Chevallier, M Elliott, J Baulieux, M Pouyet, C Trepo
Journal: Hepatology (1997)

Recurrent hepatitis C virus (HCV) in liver transplant patients is a major cause of graft loss, liver failure, and need for retransplantation. The results available to date with the use of interferon alfa (IFN-alpha) in the treatment of recurrent HCV in liver transplant patients have been disappointing. The aim of this study was to evaluate the efficacy and clinical utility of post-transplant combination therapy with IFNalpha2b (3 million units 3 times weekly) and oral ribavirin (1,200 mg/d) for a duration of 6 months, followed by maintenance with ribavirin alone for an additional 6 months. Twenty-one liver transplant recipients with recurrent hepatitis C infection (HCV-RNA-positive; active hepatitis without rejection on biopsy) were enrolled in this study. Pretreatment serum alanine transaminase (ALT) levels were at least two times the upper limit of normal. Before treatment, all patients were HCV-RNA-positive and mean HCV-RNA titers were 125 million genome-equivalents/mL. Mean pretreatment histological score was 6.3 +/- 2. After 6 months of combination therapy, all 21 patients had normal ALTs. Ten patients (48%) cleared HCV-RNA from their serum, as assessed by polymerase chain reaction (PCR), and HCV-RNA levels decreased significantly in the others (P = .0001). Improvement in histological score was seen in all patients after combination therapy (P = .0013). During maintenance ribavirin monotherapy, ALT remained normal in all but 1 of the 18 patients who tolerated therapy. HCV-RNA reappeared in 5 patients, but HCV-RNA levels did not return to pretreatment levels (P = .0004). Comparison of pretreatment and postribavirin monotherapy liver biopsies revealed improvement in all but 1 of the 18 patients who tolerated ribavirin (P = .0002). Side effects were restricted to anemia, which necessitated cessation of ribavirin therapy in 3 patients. No patient experienced graft rejection during the study period. These results are significantly better than those reported with IFN-alpha monotherapy. Most importantly, there was a complete absence of graft rejection. These results suggest that the combination of IFN-alpha and ribavirin is effective in reducing HCV-RNA levels and ameliorating hepatocellular injury in recurrent HCV after liver transplantation, and that maintenance therapy with ribavirin monotherapy can maintain the biochemical and histological response.
Polymyositis Treated with Penicillin
Authors: I. Friedmann, F. Por
Journal: BMJ (1947)

An important feature of the following case of what is a relatively rare condition was the good response to penicillin, altering the course of the disease from a moribund state to complete recovery. Case HistoryThe patient, a peasant woman aged 42, wits admitted to hospital on May 28, 1946.She had been taken ill rather suddenly on May 19, when she had a rigor and felt some pain in her right arm and left leg.The following day all her limbs were painful, but they did not swell until the third day of illness, when all limbs gradually became swollen.Her face remained unaffected.She felt very weak and perspired freely.The temperature was not taken.On the fifth day her condition be- -came worse, the pain increased, and she felt " much heavier."She called in a doctor, who found her temperature to be 100.4°F.(38°C.).He gave her some medicine, but her con- dition did not improve.On the tenth day of her illness she was transferred to our hospital.On examination all her limbs were greatly enlarged; the skin was tense and glistening; and active and passive movements
THE IMMUNOLOGIC ASPECTS OF GONOCOCCIC INFECTION
Authors: P. S. PELOUZE
Journal: JAMA (1934)

No one would deny that the interest in gonococcic infections is greater today than at any time since the epoch making work of such men as Finger, Neisser and Bumm focused medical attention on this disease as it never had been centered before. They started the march of progress along scientific lines that soon were abandoned to a great degree when physicians began to search for drugs to kill gonococci. This long quest for bactericides that would penetrate tissue and kill gonococci had a definite tendency to narrow the field of vision until one thought almost solely in terms of gonococci and chemicals with which to kill them. But most of this is changed now and physicians are thinking largely in terms of patients and gonococci, with bactericidal dreams far in the background. Assuredly it is in this direction that progress lies.  With such a salutary change in view, it
Increased levels of circulating islet amyloid polypeptide in patients with chronic renal failure have no effect on insulin secretion.
Authors: B Ludvik, M Clodi, A Kautzky-Willer, M Schuller, H Graf, E Hartter, G Pacini, R Prager
Journal: Journal of Clinical Investigation (1994)

To elucidate the metabolism of islet amyloid polypeptide (IAPP) with respect to a possible renal elimination we investigated IAPP levels in 20 lean, nondiabetic patients with renal failure maintained on chronic hemodialysis (HD) and in 20 healthy controls. The basal levels of IAPP were significantly higher in uremic patients than in controls (15.1 +/- 3.2 vs. 3.2 +/- 0.2 pM, P < 0.001) suggesting renal excretion of IAPP. To investigate the impact of chronically elevated levels of endogenous IAPP on insulin secretion and insulin sensitivity, a frequently sampled intravenous glucose tolerance test (FSIGT) was performed in a subset of patients on hemodialysis and in age-matched healthy controls (C) and obese patients with normal (NGT) and with impaired glucose tolerance (IGT). Insulin sensitivity index (SI) was 8.7 +/- 1.5 in C (P < 0.05 vs. NGT, P < 0.01 vs. IGT), 5.4 +/- 0.9 in HD (P < 0.05 vs. IGT), 3.1 +/- 1.0 in NGT, and 2.0 +/- 0.5 in IGT. First phase insulin secretion was increased in patients on HD compared with those of several control groups. The results of this study therefore indicate a renal route of metabolism of IAPP. Increased endogenous circulating IAPP levels over a long period of time do not lead to a decrease in insulin release in patients on HD and do not cause the insulin resistance commonly seen in obesity and diabetes. Increased levels of circulating IAPP therefore are not likely to be a pathogenetic factor in the development of non-insulin-dependent diabetes mellitus (NIDDM).
Embodiment in language-based memory: Some qualifications
Authors: Manuel de Vega
Journal: Behavioral and Brain Sciences (1997)

(1) Non-projectable properties as opposed to the clamping of projectable properties play a primary role in triggering and guiding human action. (2) Embodiment in language-mediated memories should be qualified: (a) Language imposes a radical discretization on body constraints (second-order embodiment). (b) Metaphors rely on second-order embodiment. (c) Language users sometimes suspend embodiment.
Paul H. Harmon, PhD, MD
Authors: Dorothy R. Harmon
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PHYSICAL, CHEMICAL, AND ULTRASTRUCTURAL STUDIES OF WATER-SOLUBLE HUMAN AMYLOID FIBRILS
Authors: Mordechai Pras, Dorothea Zucker-Franklin, Abraham Rimon, Edward C. Franklin
Journal: The Journal of Experimental Medicine (1969)

Amyloid fibrils were isolated from the tissues of nine patients with amyloidosis in a state of high purity by homogenization of the tissue followed by extraction with distilled water. Physical, chemical, and ultrastructural studies suggest that amyloid fibrils from different individuals resemble each other, but are not identical. In tissue sections as well as by negative staining of isolated fibrils, morphologic variations were observed. Among the isolated fibrils at least three types were noted. The majority resembled those described previously. However, one subject had two types of fibrils which differed in size and appearance. Most of the preparations sedimented as a single component with a sedimentation coefficient of 45–50S or as a larger polymer. However, two of the preparations had sedimentation coefficients of 8–9S, and a third one had a major 95S component and a minor 9S fraction. While the preparations of amyloid were not sufficiently pure for amino acid analyses, peptide maps demonstrated differences among amyloid preparations from different subjects. The amyloid fibrils in their native state proved to be remarkably resistant to digestion by a number of proteolytic enzymes. Several chemical methods were tried to produce smaller subunits. Of these, the most successful one was the use of 0.1 M NaOH which yielded a smaller, soluble fraction with sedimentation coefficients ranging from 1.1 to 2.8S. Accompanying this degradation, there was little loss of peptides or carbohydrates. Based on the results of the chemical analyses, it is estimated that the subunit produced by sodium hydroxide had a molecular weight of approximately 35,000–40,000.
Three patients with middle-age-onset hemochromatosis caused by novel mutations in the hemojuvelin gene
Authors: Chizu Koyama, Hisao Hayashi, Shinya Wakusawa, Toshio Ueno, Motoyoshi Yano, Yoshiaki Katano, Hidemi Goto, Ryuichi Kidokoro
Journal: Journal of Hepatology (2005)
Israeli doctors are told what to do when medicine and religion clash
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2006)

The ethics bureau of the Israel Medical Association has released a position paper to guide its members on how to act when their medical training clashes with their patients' faith and beliefs.

Avinoam Reches, chairman of the ethics bureau and a senior neurologist at Hadassah University Medical Centre in Jerusalem, said he hopes the guidelines—published in the latest issue of the association's Hebrew language magazine, Zman Harefuah— would help colleagues in a country where religion and faith in general …
Tracheal Obstruction after Insertion of a Self-Expanding Metal Esophageal Stent: Successful Management with an Endotracheal Tube, Steroids, and Radiotherapy
Authors: J. F. Alvares, H. Devarbhavi, S. Shetty, A. Pais, S. Sharma
Journal: Endoscopy (2002)

We report a new way of managing the airway compromise which can occur after placement of an esophageal self-expanding metal stent (SEMS) [1] [2] [3] [4] [5].
Neuropsychological impairment in patients with chronic hepatitis C
Authors: Robin C. Hilsabeck, William Perry, Tarek I. Hassanein
Journal: Hepatology (2002)

Hepatitis C is the most common cause of chronic liver disease in the United States and it significantly reduces quality of life. The role of cognitive deficits contributing to the morbidity of this disease has not been well characterized. The purpose of this study was to examine cognitive functioning in patients with chronic hepatitis C and to investigate relationships among parameters of disease severity and performance on neuropsychological tests. Sixty-six patients with chronic hepatitis C and 14 patients with other chronic liver diseases were administered a brief battery of neuropsychological tests assessing attention, visuoconstructional ability, learning, memory, and psychomotor speed. Cognitive impairment in patients with chronic hepatitis C ranged from 0% on a visuoconstructional task to 82% on a measure of sustained attention and concentration. Test scores of patients with chronic hepatitis C did not differ from those of patients with other chronic liver diseases. Hence, patients with and without chronic hepatitis C experience cognitive deficits, especially in tasks requiring attention and psychomotor speed. In addition, there was a significant relationship between fibrosis stage and test performance, with greater fibrosis associated with poorer performance. However, both patients with and without cirrhosis exhibited cognitive dysfunction. In conclusion, these findings suggest that progressive hepatic injury may result in cognitive problems even before the development of cirrhosis. Future studies need to determine the effect of this decrease in cognitive function on quality of life.
Hermann Pinkus (1905–1985)
Authors: A. Lyell
Journal: British Journal of Dermatology (1986)

Journal Article Hermann Pinkus (1905–1985) Get access A. Lyell A. Lyell Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue 4, 1 October 1986, Pages 507–509, https://doi.org/10.1111/j.1365-2133.1986.tb06247.x Published: 01 October 1986
On Fractures and Dislocations.
Authors: R S Suter
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radioisotope Detection of Meckel's Diverticulum Causing Acute Rectal Hemorrhage
Authors: Zachary M. Kilpatrick, Cirilo A. Aseron
Journal: New England Journal of Medicine (1972)

HEMORRHAGE from Meckel's diverticulum almost invariably arises from peptic ulceration of small-bowel mucosa adjacent to heterotopic gastric mucosa in the diverticulum.1 , 2 This gastric mucosa shares with the normally located gastric mucosa the capacity to secrete hydrochloric acid2 as well as the capacity to concentrate the isotope 99mTc sodium pertechnetate.3 An abdominal scan after the administration of this isotope will show activity over the stomach. A scan may also demonstrate uptake over the area of the diverticulum and thus provide helpful preoperative information.In the following case a scan led to the correct preoperative diagnosis after conventional barium x-ray and selective . . .