Dimethyltriazenoimidazole Carboxamide Therapy of Malignant Glucagonoma
Authors: GARY M. STRAUSS
Journal: Annals of Internal Medicine (1979)

Brief Reports1 January 1979Dimethyltriazenoimidazole Carboxamide Therapy of Malignant GlucagonomaGARY M. STRAUSS, M.D., SIGMUND A. WEITZMAN, M.D., THOMAS T. AOKI, M.D.GARY M. STRAUSS, M.D.Search for more papers by this author, SIGMUND A. WEITZMAN, M.D.Search for more papers by this author, THOMAS T. AOKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-57 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPancreatic alpha cell tumors that secrete glucagon have stimulated considerable interest recently. They have been associated with a striking and distinctive clinical syndrome characterized by the skin rash of necrolytic migratory erythema, weight loss, glucose intolerance, anemia, stomatitis, and hepatic metastases in most cases(1). Streptozocin has been used with sporadic, though not consistent, success. Efficacy for dimethyltriazenoimidazole carboxamide (DTIC) in this disease has been suggested in a single previous case report (2). We report here a rather remarkable response to DTIC in a patient with the malignant glucagonoma syndrome.A 43-year-old white man presented to Massachusetts General Hospital in...References1. MALLINSONBLOOMWARINSALMONCOX CSAPB: A glucagonoma syndrome. Lancet 2:1-5, 1974 CrossrefMedlineGoogle Scholar2. KESSINGERLEMONFOLEY AHJ: The glucagonoma syndrome and its management. J Surg Oncol 9:419-424, 1977 CrossrefMedlineGoogle Scholar3. SCULLY R (ed.): Case records of the Massachusetts General Hospital. N Engl J Med 292:1117-1123, 1975 MedlineGoogle Scholar4. UNGERAGUILAR-PARADAMÜLLEREISENTRAUT REWA: Studies of pancreatic alpha cell function in normal and diabetic subjects. J Clin Invest 49:837-848, 1970 CrossrefMedlineGoogle Scholar5. KESSINGERFOLEYLEMON AJH: Use of DTIC in the malignant carcinoid syndrome. Cancer Treat Rep 61:101-102, 1977 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Harvard Medical School Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNeuroendocrine TumorsMultiple Endocrine Neoplasia Type 1Neuroendokrine Tumoren (NET)ChemotherapyA case of malignant pancreatic endocrine tumor with marked response to systemic chemotherapy with dacarbazineA Case of Glucagonoma with Liver Metastasis: Complete Response to DacarbazineTumoren des endokrinen SystemsTumoren und tumorartige Läsionen des Dickdarms, Anorektums und PerianalbereichesTherapy of the Malignant Carcinoid Syndrome and Metastatic Islet Cell CarcinomaMetastatic medullary thyroid carcinoma: Complete response to combination chemotherapy with dacarbazine and 5-fluorouracil10 Multiple endocrine neoplasiaProspective study of chemotherapy in patients with metastatic gastrinomaPankreaskarzinomRetrobulbar neuritis as the first sign of the glucagonoma syndromeA glucagon-secreting pancreatic alpha islet cell tumor presenting as spinal cord compressionSurgery for gut hormone-producing tumorsChemotherapy of metastatic carcinoid and islet cell tumors: A reviewSuccessful treatment of glucagonoma-related necrolytic migratory erythema with dacarbazineA functional study of a case of glucagonoma exhibiting typical glucagonoma syndromeTumoren und tumorartige Läsionen des Dickdarms, Anorektums und PerianalbereichesCase Report: The Insidious Development of Symptomatic Secondary Hormone Syndromes in Patients with Malignant Endocrine TumorsEffect of streptozotocin in a case of glucagon-secreting malignant islets-cell tumorLEARNING AND BEHAVIOUR PROBLEMS ASSOCIATED WITH THEOPHYLLINE THERAPYSUCCESSFUL TREATMENT OF METASTATIC GLUCAGONOMA WITH DACARBAZINEMultiple endocrine neoplasia syndromesTherapy of malignant APUD cell tumors: Effectiveness of DTICUnsuccessful DTIC treatment of a Patient with Glucagonoma SyndromeGlucagonoma and its angiographic diagnosisGenetic Aspects of Endocrine NeoplasiaGlucagonoma tumors and syndromeA familial glucagonoma syndromeDimethyltriazenoimidazole carboxamide therapy of islet cell carcinoma of the pancreasEndokrine Tumoren des GastrointestinaltraktesMalignant Glucagonoma Syndrome: Response to ChemotherapySAMUEL P. MARYNICK, M.D., WARREN R. FAGADAU, M.D., LEWIS A. DUNCAN, M.D.Pancreatic glucagonoma with and without syndromeMetastatic glucagonoma 1 January 1979Volume 90, Issue 1Page: 57-58KeywordsAnemiaErythemaFellowshipsGlucagonGlucose intoleranceLiverPatientsRashesWeight loss Issue Published: 1 January 1979 PDF DownloadLoading ...