Impaired Glucose Tolerance in HIV-Infected Patients
Authors: Zuhayr T. Madhun, Baha M. Arafah, Grace A. McComsey
Journal: Annals of Internal Medicine (1999)

Letters2 November 1999Impaired Glucose Tolerance in HIV-Infected PatientsZuhayr T. Madhun, MD, Baha M. Arafah, MD, and Grace A. McComsey, MDZuhayr T. Madhun, MDUniversity Hospitals of Cleveland; Cleveland, OH 44106 (Madhun)University Hospitals of Cleveland; Cleveland, OH 44106 (Arafah)University Hospitals of Cleveland; Cleveland, OH 44106 (McComsey)Search for more papers by this author, Baha M. Arafah, MDUniversity Hospitals of Cleveland; Cleveland, OH 44106 (Madhun)University Hospitals of Cleveland; Cleveland, OH 44106 (Arafah)University Hospitals of Cleveland; Cleveland, OH 44106 (McComsey)Search for more papers by this author, and Grace A. McComsey, MDUniversity Hospitals of Cleveland; Cleveland, OH 44106 (Madhun)University Hospitals of Cleveland; Cleveland, OH 44106 (Arafah)University Hospitals of Cleveland; Cleveland, OH 44106 (McComsey)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-9-199911020-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Mauss and colleagues (1) presented retrospective data on serum glucose levels in HIV-infected patients and concluded that protease inhibitors, male sex, and older age are risk factors for impaired glucose tolerance in such patients. Although the data were of interest, the study did not address the potential contribution of many drugs known to impair glucose metabolism, such as glucocorticoids and megestrol acetate (2). Similarly, in the reverse-transcriptase inhibitor group, the authors failed to account for the effect of didanosine alone, which is known to cause abnormalities in glucose homeostasis (2). Use of another drug known to cause ...References1. Mauss S, Wolf E, Jaeger H. Impaired glucose tolerance in HIV-positive patients receiving and those not receiving protease inhibitors [Letter]. Ann Intern Med. 1999;130:162-3. LinkGoogle Scholar2. Kilby JM, Tabereaux PB. Severe hyperglycemia in an HIV clinic: preexisting versus drug-associated diabetes mellitus. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17:46-50. CrossrefMedlineGoogle Scholar3. Assan R, Perronne C, Assan D, Chotard L, Mayaud C, Matheron S, et al . Pentamidine-induced derangements of glucose homeostasis. Determinant roles of renal failure and drug accumulation. A study of 128 patients. Diabetes Care. 1995;18:47-55. CrossrefMedlineGoogle Scholar4. Report of the expert committee on the diagnosis and classification of diabetes mellitus. American Diabetes Association. Diabetes Care. 1999; 22(Suppl 1):S11. Google Scholar Author, Article, and Disclosure InformationAuthors: Zuhayr T. Madhun, MD; Baha M. Arafah, MD; Grace A. McComsey, MDAffiliations: University Hospitals of Cleveland; Cleveland, OH 44106 (Madhun)University Hospitals of Cleveland; Cleveland, OH 44106 (Arafah)University Hospitals of Cleveland; Cleveland, OH 44106 (McComsey) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImpaired Glucose Tolerance in HIV-Positive Patients Receiving and Those Not Receiving Protease Inhibitors Stefan Mauss , Eva Wolf , and Hans Jaeger Saquinavir-Induced Hypoglycemia in Type 2 Diabetes Oren Zimhony and David Stein Metrics 2 November 1999Volume 131, Issue 9Page: 715-716KeywordsDrug metabolismDrugsGlucoseGlucose intoleranceGlucose metabolismLipid profilesMedical risk factorsObesityOverweightProtease inhibitors ePublished: 15 August 2000 Issue Published: 2 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...