Are There Different Forms of Life in the Antineutrophil Cytoplasmic Antibody Universe?
Authors: Gary S. Hoffman, Carol A. Langford
Journal: Annals of Internal Medicine (2005)

Editorials1 November 2005Are There Different Forms of Life in the Antineutrophil Cytoplasmic Antibody Universe?Gary S. Hoffman, MD, MS and Carol A. Langford, MD, MHSGary S. Hoffman, MD, MSFrom Cleveland Clinic Foundation, Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195.Search for more papers by this author and Carol A. Langford, MD, MHSFrom Cleveland Clinic Foundation, Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-9-200511010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The causes of most forms of noninfectious vasculitis are unknown, despite being labeled as “autoimmune.” For some autoimmune diseases, autoantibodies and their target antigens provide some information about pathogenesis and disease phenotypes. What do antineutrophil cytoplasmic antibodies (ANCAs) tell us about a patient with vasculitis? Does ANCA or the antigen that it recognizes identify patients whose vasculitis differs in clinical expression and relapse potential? If so, might this information guide treatment? Two articles in this issue (1, 2) address these questions.Antibody directed against certain neutrophil cytoplasmic proteins (ANCA) is present in several forms of vasculitis. Wegener granulomatosis is characterized ...References1. Sablé-Fourtassou R, Cohen P, Mahr A, Pagnoux C, Mouthon L, Jayne D, et al. Antineutrophil cytoplasm antibodies and the Churg–Strauss syndrome. Ann Intern Med. 2005;143:632-8. LinkGoogle Scholar2. Hogan SL, Falk RJ, Chin H, Cai J, Jennette CE, Jennette JC, et al. Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody–associated small-vessel vasculitis. Ann Intern Med. 2005;143:621-31. LinkGoogle Scholar3. Hoffman GS, Specks U. Antineutrophil cytoplasmic antibodies. Arthritis Rheum. 1998;41:1521-37. [PMID: 9751084] CrossrefMedlineGoogle Scholar4. Falk RJ, Jennette JC. ANCA small-vessel vasculitis. J Am Soc Nephrol. 1997;8:314-22. [PMID: 9048352] CrossrefMedlineGoogle Scholar5. 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A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis. Rheumatology (Oxford). 2002;41:1313-7. [PMID: 12422006] CrossrefMedlineGoogle Scholar9. De Groot K, Rasmussen N, Bacon PA, Tervaert JW, Feighery C, Gregorini G, et al. Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 2005;52:2461-9. [PMID: 16052573] CrossrefMedlineGoogle Scholar10. Jayne D, Rasmussen N, Andrassy K, Bacon P, Tervaert JW, Dadoniené J, et al. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med. 2003;349:36-44. [PMID: 12840090] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Gary S. Hoffman, MD, MS; Carol A. Langford, MD, MHSAffiliations: From Cleveland Clinic Foundation, Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195.Disclosures: None disclosed.Corresponding Author: Gary S. Hoffman, MD, MS, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.Current Author Addresses: Drs. Hoffman and Langford: Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPredictors of Relapse and Treatment Resistance in Antineutrophil Cytoplasmic Antibody–Associated Small-Vessel Vasculitis Susan L. Hogan , Ronald J. Falk , Hyunsook Chin , Jianwen Cai , Caroline E. Jennette , J. Charles Jennette , and Patrick H. Nachman Antineutrophil Cytoplasmic Antibodies and the Churg–Strauss Syndrome Régis Sablé-Fourtassou , Pascal Cohen , Alfred Mahr , Christian Pagnoux , Luc Mouthon , David Jayne , Daniel Blockmans , Jean-François Cordier , Philippe Delaval , Xavier Puechal , Dominique Lauque , Jean-François Viallard , Abdelkader Zoulim , and Loïc Guillevin , and the French Vasculitis Study Group*Various Forms of Life in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Susan L. Hogan , Ronald J. Falk , Patrick H. Nachman , and J. Charles Jennette Various Forms of Life in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Gary S. Hoffman and Carol A. Langford Metrics Cited byA 49-Year-Old Woman Presenting With Cavitary Lung Lesions: A Case ReportANCA-Associated Vasculitis—ENT InvolvementHLA-DPB1 variant rs3117242 is associated with anti-neutrophil cytoplasmic antibody-associated vasculitides in a Han Chinese populationGenetic variants in ANCA-associated vasculitis: a meta-analysisGranuloma in ANCA-Associated Vasculitides: Another Reason to Distinguish Between Syndromes?Reticulate erythema associated with violaceous papules on the forearmsGenetically Distinct Subsets within ANCA-Associated VasculitisKapitel E1 Literaturverzeichnis zu Peter, Pichler, Müller-Ladner (Hrsg.): Klinische ImmunologieChurg–Strauss SyndromeTratamiento de las vasculitis sistémicas asociadas a ANCATreatment of ANCA-associated systemic vasculitisChurg–Strauss syndrome: evidence for disease subtypes?Antineutrophil Cytoplasmic Antibody–Associated VasculitisA little help from our friends: what an epidemiologic study teaches us about autoinflammation, granuloma and proteinase-3-specific antineutrophil cytoplasmic autoantibodiesFunctionally relevant variations of the interleukin-10 gene associated with antineutrophil cytoplasmic antibody-negative Churg-Strauss syndrome, but not with Wegener's granulomatosisDevelopment and initial evaluation of a measure of self-management for adults with antineutrophil cytoplasmic antibody-associated small-vessel vasculitisSmall-vessel vasculitis: Therapeutic managementANCA Are Detectable in Nearly All Patients with Active Severe Wegener’s GranulomatosisPregnancy and VasculitisVasculitis in the Geriatric PopulationVarious Forms of Life in Antineutrophil Cytoplasmic Antibody–Associated VasculitisSusan L. Hogan, PhD, MPH, Ronald J. Falk, MD, Patrick H. Nachman, MD, and J. Charles Jennette, MD 1 November 2005Volume 143, Issue 9Page: 683-685KeywordsAntigensAutoimmune diseasesBiopsyCyclophosphamideGlomerulonephritisPatientsPhenotypesSpecificityVasculitisWegener granulomatosis ePublished: 1 November 2005 Issue Published: 1 November 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...