High-Dosage Vitamin E Supplementation and All-Cause Mortality
Authors: Joseph E. Baggott
Journal: Annals of Internal Medicine (2005)

Letters19 July 2005High-Dosage Vitamin E Supplementation and All-Cause MortalityJoseph E. Baggott, PhDJoseph E. Baggott, PhDFrom the University of Alabama at Birmingham, Birmingham, AL 35294.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-2-200507190-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Before the public embraces Miller and colleagues' conclusions (1), several problems with their study should be addressed. First, factorial design data should not have been presented in Figure 3. The plot is much less convincing when data from Figure 4 are used. The SPACE study (2) is incorrectly listed as nonfactorial in Miller and colleagues' Table 1; 42% to 57% of the vitamin E and placebo groups were prescribed varying doses of vitamins (including 100 to 500 mg/d of ascorbic acid).Second, the vitamin E group was overweighted for diseases and mortality risk factors in the high-dose ...References1. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37-46. [PMID: 15537682] LinkGoogle Scholar2. Boaz M, Smetana S, Weinstein T, Matas Z, Gafter U, Iaina A, et al. Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial. Lancet. 2000;356:1213-8. [PMID: 11072938] CrossrefMedlineGoogle Scholar3. McNeil JJ, Robman L, Tikellis G, Sinclair MI, McCarty CA, Taylor HR. Vitamin E supplementation and cataract: randomized, controlled trial. Ophthalmology. 2004;111:75-84. [PMID: 14711717] CrossrefMedlineGoogle Scholar4. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet. 1996;347:781-6. [PMID: 8622332] CrossrefMedlineGoogle Scholar5. Li JY, Taylor PR, Li B, Dawsey S, Wang GQ, Ershow AG, et al. Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. J Natl Cancer Inst. 1993;85:1492-8. [PMID: 8360932] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Joseph E. Baggott, PhDAffiliations: From the University of Alabama at Birmingham, Birmingham, AL 35294.Disclosures: None disclosed PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality Edgar R. Miller III , Roberto Pastor-Barriuso , Darshan Dalal , Rudolph A. Riemersma , Lawrence J. Appel , and Eliseo Guallar High-Dosage Vitamin E Supplementation and All-Cause Mortality Edgar R. Miller III , Lawrence J. Appel , Eliseo Guallar , and Roberto Pastor-Barriuso Brief Communication: The Prevalence of High Intake of Vitamin E from the Use of Supplements among U.S. Adults Earl S. Ford , Umed A. Ajani , and Ali H. Mokdad An Editorial Update: Annus horribilis for Vitamin E Eliseo Guallar , Daniel F. Hanley , and Edgar R. Miller III High-Dosage Vitamin E Supplementation and All-Cause Mortality David H. Blatt and William A. Pryor High-Dosage Vitamin E Supplementation and All-Cause Mortality Koyamangalath Krishnan , Sharon Campbell , and William L. Stone High-Dosage Vitamin E Supplementation and All-Cause Mortality Harri Hemilä High-Dosage Vitamin E Supplementation and All-Cause Mortality Wee-Shiong Lim , Rajka Liscic , Chengjie Xiong , and John C. Morris High-Dosage Vitamin E Supplementation and All-Cause Mortality Connie Marras , Anthony E. Lang , David Oakes , Michael P. McDermott , Karl Kieburtz , Ira Shoulson , Caroline M. Tanner , and Stanley Fahn High-Dosage Vitamin E Supplementation and All-Cause Mortality Simin Nikbin Meydani , Joseph Lau , Gerard E. Dallal , and Mohsen Meydani High-Dosage Vitamin E Supplementation and All-Cause Mortality Kent J. DeZee , William Shimeall , Kevin Douglas , and Jeffrey L. Jackson High-Dosage Vitamin E Supplementation and All-Cause Mortality Antonio M. Possolo High-Dosage Vitamin E Supplementation and All-Cause Mortality Ishwarlal Jialal and Sridevi Devaraj High-Dosage Vitamin E Supplementation and All-Cause Mortality Thomas Carter Metrics Cited byBioactive Nutritional Supplements for Chronic Kidney Disease: Potential Cost BenefitsAdverse effects of vitamin E by induction of drug metabolismCellular, molecular and clinical aspects of vitamin E on atherosclerosis preventionVitamin E Regulatory Mechanisms 19 July 2005Volume 143, Issue 2Page: 155-156KeywordsConflicts of interestFactorial designHypertensionLongitudinal studiesMacular degenerationMedical risk factorsMortalityToxicityVitamin CVitamin E ePublished: 19 July 2005 Issue Published: 19 July 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...