tbuckley/cabot-search huggingface dataset:
Recurrent Pericarditis and Celiac Disease
Authors: Loren A. Laine
Journal: JAMA (1984)

IDIOPATHIC pericarditis is among the most common forms of recurrent pericarditis.<sup>1</sup>After a thorough evaluation to exclude other, treatable causes, idiopathic pericarditis is usually treated symptomatically with rest and anti-inflammatory medications.<sup>1</sup>Two recent reports from Great Britain<sup>2,3</sup>have described a potentially curable cause of "idiopathic" recurrent pericarditis: celiac disease. To the best of our knowledge, the association between recurrent pericarditis and celiac disease has not been reported previously in this country. <h3>Report of a Case</h3> A 63-year-old man was first admitted to the San Diego Veterans Administration Medical Center in 1976 with left-sided pleuritic chest pain. The patient had a pericardial rub, and chest roentgenograms showed a transient left pleural effusion. A diagnosis of pleuropericarditis was made. He was treated with aspirin, and his pain resolved. In 1981, the patient again had pleuritic chest pain. A three-component pericardial rub was heard. An ECG showed diffuse ST elevation,
ON EMBRYOTOMY IN PRESENTATIONS OF THE SUPERIOR EXTREMITIES
Authors: J. G. Swayne
Journal: BMJ (1855)

MEDCAL JOURtNAL.(O. 12 iMws.do pit Of course, it ws the duty of the engineer to stop th sugin as soon as he had arrived at the upper regions, th.spe.auw, but the duty was neglected.In conse- quece of which negligence, the man was carried up and forced betwen the roller, round which the rope was in wound, and the beam above.The back part of his head ame into contact with the beam, and the head was forced down upon the chest.In that position his body was drawn through so narow a space, that I should be afraid to say how nouw, lest I should seem to state an impossibility, but certainly it was not greater than ten or eleven inches.When I first saw him, two or three hours after the acci- doent he was perfectly sensible, but complained of great pan in the neck.He had but little power of motion in te left arm, none in the right, or in either of the legs, but sesibility to touch remained in all.His respiration was ,quite natural, and excepting the pain in the neck and the pWalytic condition of the extremities, he did not appear to be much injured.On the day following, I found him in much the same state, and it was necessary to introduce the catheter.From that time he gdually improved, and re- uired little assistance of any kind.In about a fortnight we was so far recovered as to be able to walk about-weak, certainly, in his legs, but able to walk without assistance.In this case, the cerebral vertebrie by being bent and
Cerebral Abscess and Subdural Empyema: A Review.
Authors: Adolf W. Karchmer
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Cerebral Abscess and Subdural Empyema: A Review.Adolf W. Karchmer, M.D., Morton N. Swartz, M.D., F.A.C.P.Adolf W. Karchmer, M.D.Search for more papers by this author, Morton N. Swartz, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-826_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCharts of patients with cerebral abscess and subdural empyema diagnosed at surgery or autopsy, from 1956 to 1972, were reviewed to define the clinical features, source of infection, and bacterial etiology of these entities. The diagnosis of cerebral abscess was established in 75 patients. In only 25% was the correct diagnosis made initially; brain tumor and cerebrovascular accident were frequently suspected because of the lack of manifestations of a pyogenic process. The mortality rate was 40%. The origins of infection among 70 cases studied bacteriologically were otogenic, 22; rhinogenic, 11; bacteremic, 11; traumatic, 8; pleuropulmonary, 6; congenital heart disease, 3;... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Adolf W. Karchmer, M.D.; Morton N. Swartz, M.D., F.A.C.P.Affiliations: Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 826-826KeywordsAbscessesBrainChartsCongenital heart diseaseDeath ratesEtiologyInfectious diseasesRhinovirus infectionStrokeSurgery ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
Is Radiotherapy Useful for Treating Pain in Mesothelioma?: A Phase II Trial
Authors: Nicholas MacLeod, Anthony Chalmers, Noelle O’Rourke, Karen Moore, Jonathan Sheridan, Lynn McMahon, Caroline Bray, Jon Stobo, Alan Price, Marie Fallon, Barry J. Laird
Journal: Journal of Thoracic Oncology (2015)

Radiotherapy is often used to treat pain in malignant pleural mesothelioma (MPM), although there is limited evidence to support this. The aim of this trial was to assess the role of radiotherapy for the treatment of pain in MPM.
OPEN-AIR TREATMENT OF TUBERCULOSIS: TENT LIFE IN ARIZONA.
Authors: R. W. CRAIG
Journal: JAMA (1902)

With an early diagnosis and proper treatment most cases of pulmonary tuberculosis should recover. That the disease is curable, is to-day generally recognized by medical men, and pathologists are constantly demonstrating at the postmortem table that no disease gives stronger evidence of healing tendencies than tuberculosis. Boudet of Paris recently reported 138 autopsies in which 117 revealed cicatrices of healed tuberculosis. Clinical reports from the modern open-air institutions largely confirm these statistics. The latest available information from Nordach in the Black Forest, Kimberly, South Africa, the Adirondack Cottage Sanitarium in New York, and others, show that from 20 to 35 per cent, of all cases admitted are absolutely cured as proven by the absence of bacilli, a return to good health and the resumption of the ordinary vocations of life. These clinical reports do not adequately represent the actual percentage of recoveries. By far the largest number of cases that
Rate and influence of respiratory virus co-infection on pandemic (H1N1) influenza disease
Authors: Frank P. Esper, Timothy Spahlinger, Lan Zhou
Journal: Journal of Infection (2011)

ObjectivesMany patients with influenza have more than one viral agent with co-infection frequencies reported as high as 20%. The impact of respiratory virus copathogens on influenza disease is unclear. We sought to determine if respiratory virus co-infection with pandemic H1N1 altered clinical disease.MethodsRespiratory samples from 229 and 267 patients identified with and without H1N1 influenza respectively were screened for the presence of 13 seasonal respiratory viruses by multiplex RT-PCR. Disease severity between coinfected and monoinfected H1N1 patients were quantified using a standardized clinical severity scale. Influenza viral load was calculated by quantitative RT-PCR.ResultsThirty (13.1%) influenza samples screened positive for the presence of 31 viral copathogens. The most prominent copathogens included rhinovirus (61.3%), and coronaviruses (16.1%). Median clinical severity of both monoinfected and coinfected groups were 1. Patients coinfected with rhinovirus tended to have lower clinical severity (median 0), whereas non-rhinovirus co-infections had substantially higher clinical severity (median 2). No difference in H1N1 viral load was observed between coinfected and monoinfected groups.ConclusionsRespiratory viruses co-infect patients with influenza disease. Patients coinfected with rhinovirus had less severe disease while non-rhinovirus co-infections were associated with substantially higher severity without changes in influenza viral titer.
Deficiency in Current Hemophilia Therapy: Need for Factor XIV
Authors: Peter H. Levine
Journal: JAMA (1972)

Hemophiliacs often find themselves somewhat less than sought after by physicians and hospitals, even at the largest academic centers. In return, most hemophiliacs resent the physicians and hospitals they depend on. This mutual resentment, which occasionally blossoms into overt hatred, might seem hard to fathom, especially since recent advances in the treatment of hemophilia allow us to prevent and correct the complications of this disease. A second look at the situation reveals three major reasons for the bilaterally strained doctor-patient relationship when this disease is involved. First, hemophiliacs are an economic liability to physicians and hospitals. Their chronic need for expensive medical care and for frequent hospitalizations rapidly overwhelms their limited earning power. They occasionally amass huge debts, then, when the dunning by physician or hospital becomes too great, switch to a different institution and take with them not only a debt, but a load of guilt toward the healthcare
Lung function, respiratory symptoms, and the menopausal transition
Authors: Francisco Gómez Real, Cecilie Svanes, Ernst Reidar Omenaas, Josep Maria Antò, Estel Plana, Deborah Jarvis, Christer Janson, Françoise Neukirch, Elisabeth Zemp, Julia Dratva, Matthias Wjst, Knut Svanes, Bénédicte Leynaert, Jordi Sunyer
Journal: Journal of Allergy and Clinical Immunology (2007)
Lung Tomography in Cancer Patients
Authors: William F. Sindelar
Journal: JAMA (1978)

In a retrospective study of the cases of 415 patients with various malignant neoplasms, full-lung tomography and conventional chest roentgenography were compared for accuracy in the detection of pulmonary metastases. Sufficient information was available on 410 patients to permit confirmation as to whether pulmonary metastases were present at the time of screening chest roentgenographic and tomographic examinations. On screening by routine chest roentgenography, metastases were detected in 36 patients, 66.7% of the total with confirmed metastatic disease. Screening by full-lung tomography identified metastases in 51 (94.4%). Fifteen patients with normal chest roentgenograms had metastatic lesions on tomograms. Metastases were detected in 8.8% by chest roentgenograms and in 12.4% by tomograms in a population of cancer patients with a 13.2% incidence of pathologically confirmed metastatic lesions. (<i>JAMA</i>240:2060-2063, 1978)
Maternal and Neonatal Graves' Disease
Authors: Louis J. Elsas
Journal: JAMA (1967)

LONG-ACTING thyroid stimulator (LATS)<sup>1</sup>has been found in the serum of five children with neonatal thyrotoxicosis.<sup>2-5</sup>The maternal serum was also positive for LATS in these cases, which led to the hypothesis that neonatal thyrotoxicosis was caused by LATS crossing the placenta and reaching the fetal circulation.<sup>5</sup>This hypothesis was used to explain the self-limited nature of neonatal thyrotoxicosis which usually resolved spontaneously within 3 to 12 weeks, a course which correlated with the estimated half-life of LATS (six to seven days in neonatal serum).<sup>2</sup>Some infants with neonatal thyrotoxicosis have had hepatosplenomegaly,<sup>6</sup>congestive heart failure,<sup>7</sup>jaundice,<sup>8</sup>and thrombocytopenia.<sup>9</sup>Although these findings could be due to other causes, they have occurred often enough with neonatal Graves' disease to suggest more than a chance association. The present study is, to our knowledge, the sixth reported case of neonatal thyrotoxicosis associated with LATS in
Identification of Peptide Vaccine Candidates for Prostate Cancer Patients with HLA-A3 Supertype Alleles
Authors: Satoko Matsueda, Hiroko Takedatsu, Akihisa Yao, Masahiro Tanaka, Masanori Noguchi, Kyogo Itoh, Mamoru Harada
Journal: Clinical Cancer Research (2005)

Abstract Purpose: The peptide vaccine candidates identified to date have been focused on the HLA-A2 and HLA-A24 alleles. The HLA-A11, HLA-A31, and HLA-A33 alleles share binding motifs and belong to an HLA-A3 supertype family. In this study, we attempted to identify CTL-directed peptide candidates, derived from prostate-related antigens and shared by HLA-A11+, HLA-A31+, and HLA-A33+ prostate cancer patients. Experimental Design: Based on the binding motif to the HLA-A3 supertype alleles, 42 peptides were prepared from prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA), and prostatic acid phosphatase (PAP). These peptides were first screened for their ability to be recognized by immunoglobulin G (IgG) of prostate cancer patients and subsequently for the potential to induce peptide-specific and prostate cancer–reactive CTLs from peripheral blood mononuclear cells (PBMC) of cancer patients with the HLA-A11, HLA-A31, and HLA-A33 alleles. Results: Five peptide candidates, including the PSA16-24, PAP155-163, PAP248-257, PSMA207-215, and PSMA431-440 peptides, were frequently recognized by IgGs of prostate cancer patients. These peptides efficiently induced peptide-specific and prostate cancer–reactive CTLs from PBMCs of cancer patients with the HLA-A11, HLA-A31, and HLA-A33 alleles. Antibody blocking and cold inhibition experiments revealed that the HLA-A3 supertype–restricted cytotoxicity against prostate cancer cells could be ascribed to peptide-specific and CD8+ T cells. Conclusions: We identified prostate-related antigen-derived new peptide candidates for HLA-A11-, HLA-A31-, and HLA-A33-positive prostate cancer patients. This information could facilitate the development of a peptide-based anticancer vaccine for patients with alleles other than HLA-A2 and HLA-A24.
Rehabilitation through Psychotherapy in a Residential Setting
Authors: Ch.P. Neumann
Journal: Psychotherapy and Psychosomatics (1968)

Research Articles| February 12 2010 Rehabilitation through Psychotherapy in a Residential Setting Subject Area: Psychiatry and Psychology Ch.P. Neumann Ch.P. Neumann The Silver Hill Foundation, New Canaan, Conn. Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1968) 16 (1-3): 140–145. https://doi.org/10.1159/000285927 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ch.P. Neumann; Rehabilitation through Psychotherapy in a Residential Setting. Psychother Psychosom 31 December 1968; 16 (1-3): 140–145. https://doi.org/10.1159/000285927 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1968Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Typhus and Typhoid
Authors: H. G. Dunn
Journal: BMJ (1951)

Kawasaki disease (KD) is an acute self-limiting systemic vasculitis of unknown aetiology. It is the most common cause of acquired heart disease in young children. The intense inflammatory process has a predilection for the coronary arteries, resulting in the development of aneurysmal lesions, arterial thrombotic occlusion or, potentially, sudden death. There is no specific diagnostic test; however, treatment with immunoglobulin and aspirin effectively reduces cardiac complications from 25% to 4.7% in the UK. Inflammation of the myocardium, endocardium or pericardium can occur early in the disease and endothelial dysfunction along with abnormalities of myocardial blood flow may require continuing medication, interventional catheterisation or even cardiac surgery. Several new pharmacological treatments may have important roles to play in managing KD in children and adolescents. This review discusses the history of the disease, the diagnostic challenges, epidemiology, aetiology, pathology, immunopathogenesis, treatment, genetic influences and the long-term cardiovascular sequelae.
Cyclosporine and Prostaglandins
Authors: D. ADU
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 August 1985Cyclosporine and ProstaglandinsD. ADU, M.D., C. J. LOTE, Ph.D., J. MICHAEL, F.R.C.P., J. H. TURNEY, M.R.C.P., P. MCMASTER, F.R.C.S.D. ADU, M.D.Search for more papers by this author, C. J. LOTE, Ph.D.Search for more papers by this author, J. MICHAEL, F.R.C.P.Search for more papers by this author, J. H. TURNEY, M.R.C.P.Search for more papers by this author, P. MCMASTER, F.R.C.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-2-303_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Cyclosporine and its nephrotoxicity have recently been reviewed in your journal (1). Subsequently, Dr. Duarte (2) asked whether the nephrotoxicity of cyclosporine might result from an effect on prostaglandin metabolism.We have recently suggested that the nephrotoxicity, hypertension, hyperkalaemia, and haemolytic-uraemic syndrome seen in some patients given cyclosporine therapy could be explained if this drug inhibited renal prostaglandin synthesis (3). We studied urine prostaglandin E2excretion in female renal allograft recipients treated with either prednisolone and azathioprine (11 patients) or prednisolone and cyclosporine (14 patients). The mean urinary prostaglandin E2excretion in patients given prednisolone and cyclosporine...References1. COHEN D, LOERTSCHER R, RUBIN M, TILNEY N, CARPENTER C, and STROM T. Cyclosporine: a new immunosuppressive agent for organ transplantation. Ann Intern Med. 1984;101:667-82. LinkGoogle Scholar2. DUARTE R. Cyclosporine: renal effects and prostacycline [Letter]. Ann Intern Med. 1985;102:420. LinkGoogle Scholar3. ADU D, LOTE C, MICHAEL J, TURNEY J, and MCMASTER P. Does cyclosporine inhibit renal prostaglandin synthesis? Proc Eur Dial Transplant Assoc. 1985;21:969-72. Google Scholar4. NIELD G, ROCCHI G, and IMBERTI L. Effect of cyclosporine on prostacyclin synthesis by vascular tissue in rabbits. Transplant Proc. 1983;15 (4 suppl 1):2398-400. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: D. ADU, M.D.; C. J. LOTE, Ph.D.; J. MICHAEL, F.R.C.P.; J. H. TURNEY, M.R.C.P.; P. MCMASTER, F.R.C.S.Affiliations: The Queen Elizabeth Hospital Birmingham B15 2TH, England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe pathophysiology of Sandimmune (cyclosporine) in man and animalsGout in the heart transplant recipient: Physiologic puzzle and therapeutic challengeCyclosporin A inhibits prostaglandin E2 formation by rat mesangial cells in culture 1 August 1985Volume 103, Issue 2Page: 303-303KeywordsDrug synthesisDrug therapyExcretionHypertensionProstaglandinsUrine ePublished: 1 December 2008 Issue Published: 1 August 1985 PDF downloadLoading ...
LYSIS OF T4 PHAGE BY THE SPECIFIC LIPOCARBOHYDRATE OF PHASE II SHIGELLA SONNEI
Authors: Margeris A. Jesaitis, Walther F. Goebel
Journal: The Journal of Experimental Medicine (1955)

When the specific lipocarbohydrate of Phase II Sh. sonnei and T(4) phage react in vitro, the virus is rapidly inactivated and the content of the viral membrane is released into the surrounding medium. The reaction between phage and lipocarbohydrate proceeds only in the presence of a lipide constituent which can be extracted from the polysaccharide, rendering the latter inactive, and which can be replaced by certain fatty acids. It has been suggested that the lipocarbohydrate is the receptor substance of the Phase II bacillus which specifically combines with and brings about disintegration of the virus when the latter infects the host cell.