tbuckley/cabot-search huggingface dataset:
Pericardial Hematoma After Primary Angioplasty Complicated by Coronary Rupture
Authors: Christian Zellner, Tony M. Chou, Charlie Higgins, Rod Kaiser, Nelson B. Schiller
Journal: Circulation (1998)

C oronary artery rupture is a rare complication of percutane- ous transluminal coronary angioplasty.Most patients undergo emergency bypass surgery, so the natural course of these events remains unclear.The following images demonstrate a pericardial hematoma, caused by perforation of the right coronary artery.A 59-year-old man underwent primary angioplasty during inferior myocardial infarction.Perforation of the right coronary artery was noted, with extravasation of contrast (Fig- ure), and was treated conservatively.Nine months later, the patient was referred for evaluation of a pericardial mass.MRI images and transthoracic echocardiogram demonstrate a noncommunicating intrapericardial hematoma.The patient remains symptom free.
Additive Antitumor Effect of Aromatase Inhibitor Letrozole and Antiestrogen Fulvestrant in a Postmenopausal Breast Cancer Model
Authors: Danijela Jelovac, Luciana Macedo, Olga G. Goloubeva, Venkatesh Handratta, Angela M.H. Brodie
Journal: Cancer Research (2005)

Abstract Blocking estrogen receptors with antiestrogens and blocking estrogen synthesis with aromatase inhibitors are two strategies currently being used for reducing the effect of estrogen in postmenopausal estrogen receptor–positive breast cancer patients. To optimize these treatment strategies, we have investigated whether tumor progression can be delayed by combining the pure antiestrogen fulvestrant with the nonsteroidal aromatase inhibitor letrozole. These studies were done in ovariectomized, athymic mice bearing tumors of estrogen receptor–positive human breast cancer cells stably transfected with the aromatase gene (MCF-7Ca). Groups of mice with equivalent tumor volumes were injected s.c. daily with vehicle (control; n = 6), fulvestrant (1 mg/d; n = 7), letrozole (10 μg/d; n = 18), or letrozole (10 μg/d) plus fulvestrant (1 mg/d; n = 5). All treatments were effective in suppressing tumor growth compared with controls (P &amp;lt; 0.001). Tumor volumes of the fulvestrant-treated group had doubled in 10 weeks. After 19 weeks of letrozole (10 μg/d) treatment when tumors had nearly doubled in volume, mice (n = 18) were assigned to second-line therapy with letrozole (100 μg/d; n = 6), tamoxifen (100 μg/d; n = 6), or remained on letrozole treatment (10 μg/d; n = 6). However, tumors continued to increase in volume in these groups. Tumors of animals treated with the combination of letrozole plus Faslodex regressed over 29 weeks of treatment by 45%. Thus, the combination of letrozole plus fulvestrant was more effective in suppressing tumor growth than either letrozole or fulvestrant alone or sequential therapies with tamoxifen or a higher dose of letrozole (100 μg/d).
A PRACTICAL APPARATUS FOR ASPIRATING AND WASHING THE PLEURA
Authors: A. J. de Martini
Journal: JAMA (1926)

This apparatus works on the principle of withdrawing the purulent exudate, at the same time introducing into the pleura a mild antiseptic solution, following which air can be sub-stituted. It consists of a graduated bottle containing 1,000 cc., and a cork with two openings into which pass two metal tubes. The right tube is connected to a rubber bulb. The left tube is connected to an especially constructed cock with four openings. The upper opening of the cock connects by a metal tube to the inside of the bottle; the left opening is connected to a pleura needle. The lower opening is connected by a rubber tube to a 100 cc. glass syringe. The right opening is a metal tube with a two way cock so that when the cock is open, fluid can be forced from the pleura to a receiving vessel outside; or, if the cock
Anatomical Resection Improves Survival Over Wedge Resection of Pulmonary Metastases of Colorectal Origin in the Spanish Prospective Multicenter Study (GECMP-CCR)
Authors: L. Molins, J. Hernandez, J.J. Fibla, F. Heras, R. Embun, J.J. Rivas de Andres
Journal: Annals of Oncology (2015)
Sialomucins at resection margin and likelihood of recurrence in colorectal carcinoma.
Authors: N A Habib, P M Dawson, J W Bradfield, R C Williamson, C B Wood
Journal: BMJ (1986)

Oncogenic transformation of colonic epithelium is accompanied by changes in surface carbohydrate, notably an increased secretion of sialomucins at the expense of the normally predominant sulphomucins. In a multicentre prospective trial the correlation between the presence of sialomucins at the resection margin and the subsequent development of local recurrence was studied in 250 patients who had undergone "curative" resection for colorectal carcinoma with a mean follow up period of 14 months. Nineteen of 70 patients (27.1%) with a sialomucin predominant pattern at either resection margin developed local recurrence compared with 15 of 180 patients (8.3%) with a mixed or sulphomucin predominant pattern (p less than 0.01). Increased sialomucin staining at the resection margins was associated with reduced survival in these patients (p less than 0.01). At a mean of 14 months of follow up 153 patients (85%) were alive in the sulphomucin group and 53 patients (76%) were alive in the sialomucin group. Regression analysis predicted five year survivals of 32.8% and 18.9% for the sulphomucin and sialomucin groups respectively. Abnormal mucus production at the resection margin in patients treated for colorectal carcinoma appears to identify those with a higher risk of local recurrence and reduced survival.
Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B
Authors: R S Boyd, P J Adam, S Patel, J A Loader, J Berry, N T Redpath, H R Poyser, G C Fletcher, N A Burgess, A C Stamps, L Hudson, P Smith, M Griffiths, T G Willis, E L Karran, D G Oscier, D Catovsky, J A Terrett, M J S Dyer
Journal: Leukemia (2003)
Proposed Amendments of the Constitution and Code of Ethics of the American Medical Association.—Some of the Parliamentary Questions Involved.
Authors: N. S. Davis
Journal: JAMA (1894)

Chicago, May 4, 1894. <h3>To the Editor:</h3> —When the report of the Committee on Revision of the Constitution and By-Laws, was made in the meeting of theAssociationlast year, and the President ruled that said report must lie on the table one year and be acted upon at the next annual meeting, several members contended that the ruling was wrong. They claimed that inasmuch as the proposed amendments or revised instrument had been prepared by a committee appointed for that purpose the preceding year, it was equivalent to one year's notice, and consequently was eligible for final action at once. They were quickly silenced, however, by simply reading the present constitutional provision for its amendment, as follows: "VII.—No amendment or alteration shall be made in any of these Articles, except<i>at the annual meeting next subsequent to that at which</i>such amendment or alteration may have been proposed; and
MtArt: A New Model of Amino Acid Replacement for Arthropoda
Authors: F. Abascal, D. Posada, R. Zardoya
Journal: Molecular Biology and Evolution (2006)

A statistical approach was applied to select those models that best fit each individual mitochondrial (mt) protein at different taxonomic levels of metazoans. The existing mitochondrial replacement matrices, MtREV and MtMam, were found to be the best-fit models for the mt-proteins of vertebrates, with the exception of Nd6, at different taxonomic levels. Remarkably, existing mitochondrial matrices generally failed to best-fit invertebrate mt-proteins. In an attempt to better model the evolution of invertebrate mt-proteins, a new replacement matrix, named MtArt, was constructed based on arthropod mt-proteomes. The new model was found to best fit almost all analyzed invertebrate mt-protein data sets. The observed pattern of model fit across the different data sets indicates that no single replacement matrix is able to describe the general evolutionary properties of mt-proteins but rather that taxonomical biases and/or the existence of different mt–genetic codes have great influence on which model is selected.
PM-05 * ARHGAP36 AS A NOVEL DRIVER IN HIGH-RISK HUMAN MEDULLOBLASTOMA
Authors: P. Jackson, P. Das, J. Larson, B. Moriarity, D. Largaespada
Journal: Neuro-Oncology (2014)

Medulloblastoma (MB) is the most frequent childhood malignancy of the CNS. Current trials aim to identify effective treatments with reduced side effects, but lack of knowledge regarding drivers prevents development of more precise therapies. MB is divided into four subgroups based on gene expression, histology and developmental origin: SHH, WNT, Group 3 and Group 4. Our lab identified a novel driver of MB using Sleeping Beauty (SB) insertional mutagenesis. Rho GTPase Activating Protein 36 (Arhgap36) was the top candidate to emerge from this screen, with activating insertions in 14/22 MB harvest (Larson et al., submitted). Preliminary studies with qRT-PCR, tissue microarray and immunohistochemistry showed ARHGAP36 overexpression in Group 3/4 human MB. We are employing multiple genetic techniques to elucidate the role of Arhgap36 in MB tumorigenesis. We have overexpressed ARHGAP36 in a non-tumor forming immortalized mouse cerebellar cell line (C17.2) and several human MB cell lines (Daoy, Med8A, Ons76 and two primary lines). We will also knockout ARHGAP36 expression in these lines using stable integration of the CRISPR/Cas system. We will use these lines to monitor changes in proliferation, migration, anchorage independent growth, and tumor formation in response to alterations in ARHGAP36 expression. Lastly, the novelty of ARHGAP36 warrants a non-biased approach, so we will analyze cell-wide signaling changes in cells with low, medium and high levels of ARHGAP36 expression using RNA sequencing and MicroWesterns. Arhgap36 overexpression is strongly associated with MB, and our findings indicate that it may play a driving role in Group 3 and Group 4 MB tumorigenesis. Furthermore, Arhgap36 may represent a novel target for therapeutic efforts aimed at treating patients with MB.
Prospective Relation of C-Reactive Protein With Type 2 Diabetes
Authors: Naveed Sattar, Ken Williams, Thang S. Han, Clicerio Gonzalez-Villalpando, Michael E.J. Lean, Steven M. Haffner
Journal: Diabetes Care (2003)

We thank Snijder et al. (1) for their interest in our article (2) and for sharing their data relating C-reactive protein (CRP) to the risk of diabetes development in the Hoorn Study. We readily agree that it is unclear why inflammation might be more important to the pathogenesis of type 2 diabetes in women compared with men or indeed vice versa. We have reanalyzed our CRP data using the same covariates as Snijder et al. and essentially our results are unchanged—the relation between CRP and diabetes remains strong in women, even after inclusion of waist-to-hip ratio (WHR), but is absent …
ON THE SURGICAL TREATMENT OF HAeMORRHOIDAL TUMOURS
Authors: H. Lee
Journal: BMJ (1854)

Tx the year 1843, Dr. Houston, surgeon to the City of Dublin Hospital, published an article in the Dublin Journat of fedical Sciec advocating the use of nitric acid, of a specific gravity of 1500, in two kinds of hemorrhoid affections.The first of these is described as a sort of aneurism by anastomosis of the small vessels of the mucous membrane and submucous cellular tissue: the second as of a chronic inflammatory nature, and best illustrated by comparing it to the red, villous.tender, hn3morrhagic surface exhibited by the mucous membrane of the eyelids in old cases of chronic conjunctivitis."If such be a correct view of the pathology of certain in- ternal hmemorrhoids," observes Dr. Houston, "are such severe Temedies as the knife or ligature either necessary or safe?If the seat of the baneful part of the affection lie on the surface why not rather adopt such means as will remove that surface, per 8s, without extending beyond it, rather than such as may, on the one hand, by going to an unneces- sary depth, wound vessels of such magnitude as are capable, when opened, of pouring out blood to the hazard of life; or ,on the other, by the severity of its operation, engender the the most painful and the most dangerous symptoms ?No man", continues Dr. Houston, "ever applies either the knife, -r scissors, or even the needle and ligature in any such patients without more or less misgiving as to the success, er apprehension as to the result of the experiment.It is enough to read the objections to any one of these operations as detailed by the advocates of the other, and vice versd, to be satisfied of the little confidence reposed by the profession in either."The direct application of the nitric acid to these vascular tumours, Dr. Houston was led to believe, combined in itself all the advantages possessed by excision or ligature without any of their disadvantages."The diseased surface," he says, 4'may be removed with little pain, and without danger; and in the cicatrisation which follows, a radical cure is effected.Nor do the good effects stop here: not only is a reparation of the worst part of the affection directly accomplished by this means, but in consequence of the bracing up of the general mucous membrane which follows the remnoval of the relaxed and diseased part of its surface, other varices which are present are supported and reduced in bulk.These secondary good results may be regarded as not the least important which take place."* The instrument decribed by M. Jobert, in the " Gazelte des Haitaox of the lst October, 18(,, is a modification of the above, a desciption of whe was
The Effect of Aortocoronary Bypass Grafts on Myocardial Blood Flow Reserve and Treadmill Exercise Tolerance
Authors: SUZANNE B. KNOEBEL, PAUL L. MCHENRY, JOHN F. PHILLIPS, DANIEL K. LOWE
Journal: Circulation (1974)

Twenty-five patients had myocardial blood flow reserve determinations (percentage increase in myocardial blood flow with stress), treadmill exercise tests and coronary and bypass cineangiography pre- and postaortocoronary bypass surgery. Twenty of the patients had the postoperative studies performed three months after operation, three at two months and two at five and six months, respectively. Eleven of the 25 patients had all significant coronary artery obstructions (75% or greater) bypassed and all grafts were open at the time of restudy. Preoperatively, blood flow reserve had been abnormal in nine and all had positive treadmill tests. Postoperatively, all eleven patients had normal myocardial blood flow response to stress and treadmill tests were negative in ten (one patient was not restudied on the treadmill). In six patients, no patent grafts could be demonstrated. These patients continued to show abnormal blood flow reserve and positive treadmill studies. Eight of the 25 patients had partial revascularization in that some grafts were open, some closed, and some significantly occlusive lesions were not bypassed. Four of these eight patients had normal flow and treadmill studies and the remainder continued to have an abnormal response to one or both of the measurements. The relationship between treadmill exercise response, myocardial blood flow reserve, and graft patency was significant at the 0.005 level for patients with all grafts open or closed. No significant correlation was obtained between any of the measurements in those patients with partial revascularization. The data indicate that successful aortocoronary bypass grafting provides myocardial revascularization as reflected in a return to normal of the myocardial blood flow reserve and response to treadmill stress testing.
Chronic Q Fever: 1. Clinical Aspects of a Patient with Endocarditis
Authors: A. O. Robson, C. D. G. L. Shimmin
Journal: BMJ (1959)

MALIGNANT HYPERTENSIONBmsmu 1951-8 is reported.The results observed in this group are compared with a control series previously reported from the same hospital.The expectation of life of the treated patients was increased by a factor of six to eight times that expected from the control series.Prolonged survival was particularly seen in those patients whose renal function was normal or only slightly impaired at the start of treatment.Death was most frequently due to uraemia; heart failure as a cause of death was considerably diminished in the treated group.The benefits of treatment were most pronounced on retinitis and in heart failure.Improvement in the electrocardiogram was seen in one-third of cases; reduction in cardiac size occurred somewhat less- frequently.Renal function tended to remain stationary or to improve slightly in patients with an initial blood urea level below 80 mg. per 100 ml.; where renal impairment was more severe than this progressive deterioration was the rule.Patients with neurological complications did not derive much benefit from treatment.Accompanying atherosclerosis was a limiting factor in the success of treatment, particularly in older patients.A survey of the histological lesions in the kidneys showed that after treatment with hypotensive drugs the main changes were a conversion of cellular intimal hyperplasia in the interlobular arteries to fibrous intimal thickening and a " healing " of fibrinoid degeneration to hyaline and fibrous tissue.Some correlation was likely between the degree of narrowing of the interlobular arteries at the start of treatment and prognosis.The clinical observations have been documented through the years, especially by Drs.Brenda 'Morrison, Helen Mellanby, and Edmond Murphy.We are indebted to our clinical and pathologist colleagues who co-operated in the study.We are deeply grateful to Messrs. May and
Washington Office Provides Eyes, Ears, Voice
Authors: Charles Marwick
Journal: JAMA (1990)

SINCE THE MID-1950s, the CDC has maintained an office in Washington, DC. Originally it served only as liaison with the executive branch, but in the past decade functions have expanded. In its present form, the office dates to 1980. The CDC's director at the time was William Foege, MD, and the then secretary of the Department of Health, Education, and Welfare, Joseph A. Califano, relied on him so heavily that Foege was spending more time in Washington than in Atlanta. So it was decided to set up an office staff who could represent the director when he could not be in Washington, says George Hardy, MD, the present director of the office, who adds: "Frequently, there are meetings of Public Health Service agency heads or conferences where all the agencies are supposed to be represented. This cuts down on travel and yet makes sure the CDC is represented." Hardy summarizes
Taxonomic Analysis of Depressive States of Varying Aetiology
Authors: A. Bukowczyk, A. Niwińska
Journal: Psychotherapy and Psychosomatics (1975)

A new mathematical dendrite method for the diagnosis of depressions is outlined. The method is based on an inventory of 134 items representing symptoms of features encountered in depressive states, and its aim is to determine the 'set' of each individual in a group of patients. By means of mathematical analysis the sets of individual features are arranged in such a way as to produce a dendrite, i.e., the shortest broken line connecting the various features. The sets can then be divided into subtypes. The advantages of this method - the application of which to a group of 30 test-subjects is described - are that it ensures a maximum degree of objectivity, is simple to perform, and yields easily interpretable results.
I. UNION FOLLOWING PATHOLOGICAL FRACTURE OF THE FEMUR DUE TO SECONDARY CARCINOMA. II. SPONTANEOUS DISAPPEARANCE OF CARCINOMA OF THE LIP.
Authors: LEONARD FREEMAN
Journal: JAMA (1901)

Spontaneous fractures have long been known to occur occasionally in the presence of carcinomata of various portions of the body. Particularly is this true of the harder varieties of carcinoma of the breast. Too much stress must not be placed, however, upon the older reports, because carcinoma and osteosarcoma were formerly confused under the generic term of "bone cancer." It is generally admitted that these fractures may be due to metastasis or to abnormal fragility of the bones. The latter does not depend on the presence of carcinoma elements, but upon the development of a more or less general, simple osteoporosis, intimately but obscurely associated with the existence of the primary carcinoma, Richet and Verneuil being inclined to connect the phenomenon with the phosphaturia often existing in the later stages of carcinoma. The bone most frequently broken is the femur, the humerus coming next, while multiple fractures are sometimes met
Effects of methylprednisolone on P50, 2,3 diphosphoglycerate and arteriovenous oxygen difference in acute myocardial infarction.
Authors: E S Kalter, R J Henning, L Thijs, J L Vincent, H Becker, R W Carlson, M H Weil
Journal: Circulation (1980)

In a double-blind randomized study, 30 mg/kg of methylprednisolone sodium succinate (MPN) or 15 mg/kg of mannitol placebo (PL) were infused in 28 patients after acute myocardial infarction. Measurements were obtained immediately before and after for 24 hours after the initial infusion. The partial pressure of oxygen at 50% saturation of hemoglobin (P50) did not change significantly in vitro or in vivo after MPN, whereas 2,3 diphosphoglycerate (2,3 DPG) increased from 13.2 to 14.2 mumol/g Hb (p &lt; 0.05) in the group receiving PL. The arteriovenous oxygen difference (Ca-VO2) remained constant after MPN or PL. The cardiac index (CI) increased after MPN (p &lt; 0.02) associated with an increase in the oxygen consumption index (CI X A-V O2) from 146 to 170 ml/min/m2 (p &lt; 0.05). These data show that MPN increases CI after acute myocardial infarction, but has no specific effects on P50, 2,3 DPG or Ca-VO2.