tbuckley/cabot-search huggingface dataset:
Letter to the editor: Demonstration of tsp receptor both on the cell surface and in the cytoplasm of the megakaryoblastic leukemia cell line (MEG‐01)
Authors: Nobutaka Imamura, Tominari Inada, Deo M. Mtasiwa, Atsushi Kuramoto, Michinori Ogura, Hidehiko Saito
Journal: American Journal of Hematology (1989)
Job stress, satisfaction, and mental health among general practitioners before and after introduction of new contract.
Authors: V. J. Sutherland, C. L. Cooper
Journal: BMJ (1992)

OBJECTIVE--To compare measures of job stress, job satisfaction, and mental health among general practitioners before and after the introduction of the new contract in April 1990. DESIGN--Cross sectional postal questionnaire survey in July 1990. Comparison of results with those obtained in previous survey in November 1987. SETTING--General practice in United Kingdom. SUBJECTS--1500 general practitioners randomly selected from general medical services lists, 917 of whom (61%) returned questionnaires usable for statistical analysis. MAIN OUTCOME MEASURES--Aspects of job causing stress, job satisfaction (Warr, Cook, and Wall scale), and mental health (Crown-Crisp experiential index). RESULTS--Compared with 1987, in 1990 doctors experienced more stress from night calls (mean score 3.83 in 1990 v 3.45 in 1987), emergencies during surgery hours (3.72 v 3.48), and interruption of family life by telephone (3.58 v 2.73; p less than 0.001 for all three variables). Scores for somatic anxiety and depression were higher in both men and women in 1990 (men: somatic anxiety 3.12 v 2.36; depression 3.80 v 2.94; women: somatic anxiety 3.56 v 2.65; depression 4.02 v 3.37; p less than 0.001). Job satisfaction had also decreased in 1990 (5.23 v 4.26; p less than 0.001). CONCLUSIONS--Doctors experienced more stress, less job satisfaction, and poorer mental health in 1990 than in 1987. These changes may have resulted from the introduction of the new contract.
CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors
Authors: Ryotaro Sakamori, Shiyan Yu, Xiao Zhang, Andrew Hoffman, Jiaxin Sun, Soumyashree Das, Pavan Vedula, Guangxun Li, Jiang Fu, Francesca Walker, Chung S. Yang, Zheng Yi, Wei Hsu, Da-Hai Yu, Lanlan Shen, Alexis J. Rodriguez, Makoto M. Taketo, Edward M. Bonder, Michael P. Verzi, Nan Gao
Journal: Cancer Research (2014)

Mutations in the APC or β-catenin genes are well-established initiators of colorectal cancer, yet modifiers that facilitate the survival and progression of nascent tumor cells are not well defined. Using genetic and pharmacologic approaches in mouse colorectal cancer and human colorectal cancer xenograft models, we show that incipient intestinal tumor cells activate CDC42, an APC-interacting small GTPase, as a crucial step in malignant progression. In the mouse, Cdc42 ablation attenuated the tumorigenicity of mutant intestinal cells carrying single APC or β-catenin mutations. Similarly, human colorectal cancer with relatively higher levels of CDC42 activity was particularly sensitive to CDC42 blockade. Mechanistic studies suggested that Cdc42 may be activated at different levels, including at the level of transcriptional activation of the stem cell-enriched Rho family exchange factor Arhgef4. Our results indicate that early-stage mutant intestinal epithelial cells must recruit the pleiotropic functions of Cdc42 for malignant progression, suggesting its relevance as a biomarker and therapeutic target for selective colorectal cancer intervention.
Treating tuberculosis in developing countries.
Authors: J. Glennon, D. Fegan
Journal: BMJ (1992)

Quality is defined by the American Society for Quality (ASQ) as “the totality of features and characteristics of a product or service that bears on its ability to satisfy given needs.” Therefore, quality is applicable to processes that supply outcomes with values that can be measured. Statistical control is an effective methodology that provides the outcome of quality of goods, bringing an added value that other methods, like quality by inspection, do not offer. The statistical methods applied to process control have been thoroughly developed, and the mathematics that supports them have been broadly demonstrated. Artificial Intelligence (AI) is a field in which mathematics, statistics, and programming play a joint role, and its results can also be applied to disciplines like quality control. Nevertheless, its utilization is subordinate to the qualification of the implemented algorithms. This research presents a standard procedure to AI algorithms, allowing their usage in regulated environments to ensure the quality of the delivered products or services (e.g., in drugs and medicines manufacturing). The regulated principles are defined by the concept of quality by design (QbD), which is a notion introduced in the pharmaceutical industry as a good practice for process management under multivariate analysis. This study intended to provide guidance for qualifying AI algorithms using QbD guidelines as the foundation for this purpose.
Overexpression of ADAM 10 and ADAM 12 in lesional psoriatic skin
Authors: S.T. Oh, A. Schramme, A. Stark, W. Tilgen, P. Gutwein, J. Reichrath
Journal: British Journal of Dermatology (2008)

Journal Article Overexpression of ADAM 10 and ADAM 12 in lesional psoriatic skin Get access S.T. Oh, S.T. Oh Department of Dermatology, Saarland University Hospital, 66421 Homburg/Saar, GermanyDepartment of Dermatology, Daejeon St Mary's Hospital, Medical College of the Catholic University of Korea, Korea Search for other works by this author on: Oxford Academic Google Scholar A. Schramme, A. Schramme Department of Pharmacology, Johann Wolfgang Goethe University Hospital, 60590 Frankfurt, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Stark, A. Stark Department of Dermatology, Saarland University Hospital, 66421 Homburg/Saar, Germany Search for other works by this author on: Oxford Academic Google Scholar W. Tilgen, W. Tilgen Department of Dermatology, Saarland University Hospital, 66421 Homburg/Saar, Germany Search for other works by this author on: Oxford Academic Google Scholar P. Gutwein, P. Gutwein Department of Pharmacology, Johann Wolfgang Goethe University Hospital, 60590 Frankfurt, Germany Search for other works by this author on: Oxford Academic Google Scholar J. Reichrath J. Reichrath Department of Dermatology, Saarland University Hospital, 66421 Homburg/Saar, Germany Correspondence: Jörg Reichrath. E‐mail: ostksy@yahoo.co.kr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 6, 1 June 2008, Pages 1371–1373, https://doi.org/10.1111/j.1365-2133.2008.08513.x Published: 01 June 2008
Goodpasture's syndrome and dialysis.
Authors: D Bainbridge
Journal: BMJ (1967)

ized maculo-papular rash appeared, which was partly petechial on her legs.There was no lymphadenopathy and the spleen was not palpable.The results of blood counts are shown below.* ~~~~0 0 1 11,000 4,400 (40%) 1,210 (11%) 4,950 (45%) 3 17,000 5,780 (34%) 1,050 ( 5%) 10,030 (59%) 11 12,000 4,440 (37%) 3,480 (29%) 3,360 (28%) 24 9,000 6,390 (71%) 270 ( 3%) 1,890 (21%) On days 1 and 3 nearly all the lymphocytes were atypical, and about half of these resembled glandular-fever cells.By day 11 the latter had disappeared and only an occasional lymphocyte was atypical.On day 24 the leucocyte picture was normal.The haemoglobin level and platelet count were constantly normal.Paul-Bunnell tests were repeatedly negative, and toxoplasma dye tests gave litres of 256 during and for three months after the illness.and I. D.
Minocycline-induced interstitial nephritis.
Authors: G W Hill, M Roach
Journal: BMJ (1979)

Aetiology of appendicitis SIR,-We read with interest the repeated assertion by Mr D P Burkitt and others that "the geographical distribution of appendicitis indicates that it is a disease associated with modern Western culture" (3 March, p 620).Reports, which often comprised moderately large series of cases of appendicitis, have recently been published from Africa,'-' South America,4 the Middle East,5-7 Malaysia,8 Indonesia,9 China,10 and even the Arctic."1The World Organisation of Gastroenterology re- search committee is conducting a large-scale multinational survey into the presentation of abdominal pain around the world.In every single centre, including Mexico City and Khon Kaen, Thailand, in large series of several hundred cases per centre, the commonest cause of admission to hospital with acute abdominal pain is acute appendicitis.It is not helpful therefore at the present time to equate appendicitis with modem Western culture.The relation between the two-if it exists at all-is undoubtedly far more complex than Mr Burkitt's simplistic assertion.
EU is set to use innovative solutions to help elderly people live more healthily
Authors: R. Watson
Journal: BMJ (2011)

The initial five themes to be adopted by the European Innovation Partnership on Active and Healthy Ageing have been selected and will be launched next year. The overall aim of the partnership, which is funded by the European Union, is to ensure that by 2020 the average European citizen can enjoy two more active and healthy years of life.

The themes focus on three main areas—prevention, care and cure, and independent living—and will use innovative and technological developments to meet …
Ductal Carcinoma in Situ (Intraductal Carcinoma) of the Breast
Authors: S J Schnitt, W Silen, N L Sadowsky, J L Connolly, J R Harris
Journal: New England Journal of Medicine (1988)

IN 1932, Broders defined carcinoma in situ as "a condition in which malignant epithelial cells and their progeny are found in or near positions occupied by their ancestors before the ancestors underwent malignant transformation."1 In the breast, carcinoma in situ has been categorized traditionally as either lobular or ductal, depending on the cytologic features and pattern of growth. Ductal carcinoma in situ, more commonly known as intraductal carcinoma, is characterized by a proliferation of malignant epithelial cells confined to the mammary ducts, without light-microscopical evidence of invasion through the basement membrane into the surrounding stroma. Unfortunately, in the past some . . .
BENIGN PLASMA-CELL ERYTHROPLASIA.
Authors: GEORGES GARNIER
Journal: British Journal of Dermatology (1957)

Journal Article BENIGN PLASMA‐CELL ERYTHROPLASIA. Get access GEORGES GARNIER GEORGES GARNIER Hôpital St.‐Louis, Paris Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 69, Issue 3, 1 March 1957, Pages 77–81, https://doi.org/10.1111/j.1365-2133.1957.tb13232.x Published: 01 March 1957
Work factors and behavioural coping in relation to withdrawal from the labour force in patients with rheumatoid arthritis
Authors: A M J Chorus
Journal: Annals of the Rheumatic Diseases (2001)

<h3>OBJECTIVE</h3> To assess separate and combined effects of work factors and behavioural coping in relation to withdrawal from the labour force among patients with rheumatoid arthritis (RA). <h3>METHODS</h3> A cross sectional study was conducted in a Dutch nationwide random sample of 720 patients with RA. Information about work factors and behavioural coping was collected by a self-administered postal questionnaire. A broad variety of work factors and coping styles were evaluated separately and in combination using multivariate logistic regression analyses, controlling for sociodemographic and disease related variables. Attributable and preventable fractions were calculated from the combined analyses to assess the relative importance of the contributing factors. <h3>RESULTS</h3> Additional job training, equal career opportunities, letting the disease influence the choice of the current job position, and informing colleagues about having the disease were negatively associated with withdrawal from the labour force. The most relevant factor in terms of decreasing the risk was adjusting job demands which accounted for 63% of the patients still in the labour force. Decreasing activities and diverting attention in order to cope with pain, and pacing in order to cope with limitations were the coping styles which were positively associated with withdrawal from the labour force. The most relevant factor in terms of increasing the risk of withdrawal was pacing which accounted for 67% of the withdrawals. <h3>CONCLUSION</h3> Work factors are potentially important modifiable risk factors for withdrawal from the labour force in patients with RA. Behavioural coping is also relevant.
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
Authors: Christian Hansen, Elodie Angot, Ann-Louise Bergström, Jennifer A. Steiner, Laura Pieri, Gesine Paul, Tiago F. Outeiro, Ronald Melki, Pekka Kallunki, Karina Fog, Jia-Yi Li, Patrik Brundin
Journal: Journal of Clinical Investigation (2011)

Post-mortem analyses of brains from patients with Parkinson disease who received fetal mesencephalic transplants show that α-synuclein–containing (α-syn–containing) Lewy bodies gradually appear in grafted neurons. Here, we explored whether intercellular transfer of α-syn from host to graft, followed by seeding of α-syn aggregation in recipient neurons, can contribute to this phenomenon. We assessed α-syn cell-to-cell transfer using microscopy, flow cytometry, and high-content screening in several coculture model systems. Coculturing cells engineered to express either GFP– or DsRed-tagged α-syn resulted in a gradual increase in double-labeled cells. Importantly, α-syn–GFP derived from 1 neuroblastoma cell line localized to red fluorescent aggregates in other cells expressing DsRed–α-syn, suggesting a seeding effect of transmitted α-syn. Extracellular α-syn was taken up by cells through endocytosis and interacted with intracellular α-syn. Next, following intracortical injection of recombinant α-syn in rats, we found neuronal uptake was attenuated by coinjection of an endocytosis inhibitor. Finally, we demonstrated in vivo transfer of α-syn between host cells and grafted dopaminergic neurons in mice overexpressing human α-syn. In summary, intercellularly transferred α-syn interacts with cytoplasmic α-syn and can propagate α-syn pathology. These results suggest that α-syn propagation is a key element in the progression of Parkinson disease pathology.
Low Cost Coronary Care Unit Equipment
Authors: Gerard Church
Journal: JAMA (1968)

To the Editor:—  Since the report (203, Jan 22, 1968, adv p 23) of our paper on our coronary unit we have received several requests about the details of its relatively low cost. The equipment we used was provided by the Sanborn Division of the Hewlett Packard Company. For the period which our study covered, we operated with the minimum of equipment. Each of three beds had an oscilloscope costing $501.50 and heart rate meter with light alarm costing $701.50 making a total cost for the three beds of 3 × $1,203= $3,609. The crash cart equipment consisted of the car itself ($199), a synchronized direct current defibrillator ($1,307), an oscilloscope ($501.50), an internal-external pacemaker ($279), and an electrocardiograph machine $695 making a total of $2,981. We also needed a cable ($42) and an extension cord ($11.55). A battery operated fixed rate pacemaker, a catheter, and a few small items
Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile
Authors: François Ducray, Ahmed Idbaih, Aurélien de Reyniès, Ivan Bièche, Joëlle Thillet, Karima Mokhtari, Séverine Lair, Yannick Marie, Sophie Paris, Michel Vidaud, Khê Hoang-Xuan, Olivier Delattre, Jean-Yves Delattre, Marc Sanson
Journal: Molecular Cancer (2008)

In high grade gliomas, 1p19q codeletion and EGFR amplification are mutually exclusive and predictive of dramatically different outcomes. We performed a microarray gene expression study of four high grade gliomas with 1p19q codeletion and nine with EGFR amplification, identified by CGH-array.The two groups of gliomas exhibited very different gene expression profiles and were consistently distinguished by unsupervised clustering analysis. One of the most striking differences was the expression of normal brain genes by oligodendrogliomas with 1p19q codeletion. These gliomas harbored a gene expression profile that partially resembled the gene expression of normal brain samples, whereas gliomas with EGFR amplification expressed many genes in common with glioblastoma cancer stem cells. The differences between the two types of gliomas and the expression of neuronal genes in gliomas with 1p19q codeletion were both validated in an independent series of 16 gliomas using real-time RT-PCR with a set of 22 genes differentiating the two groups of gliomas (AKR1C3, ATOH8, BMP2, C20orf42, CCNB1, CDK2, CHI3L1, CTTNBP2, DCX, EGFR, GALNT13, GBP1, IGFBP2, IQGAP1, L1CAM, NCAM1, NOG, OLIG2, PDPN, PLAT, POSTN, RNF135). Immunohistochemical study of the most differentially expressed neuronal gene, alpha-internexin, clearly differentiated the two groups of gliomas, with 1p19q codeletion gliomas showing specific staining in tumor cells.These findings provide evidence for neuronal differentiation in oligodendrogliomas with 1p19q codeletion and support the hypothesis that the cell of origin for gliomas with 1p19q codeletion could be a bi-potential progenitor cell, able to give rise to both neurons and oligodendrocytes.
Induction of Labour by Intra-amniotic Injection of Hypertonic Glucose Solution
Authors: C. Wood, R. T. Booth, J. H. M. Pinkerton
Journal: BMJ (1962)

Montgomery, D. A. D? and Weibotim, R. B. (1957). Brit. J. Surg., 45, 137. Nabarro. J. D. N.. Moxham, A., and Walker, G. (1958). J. clin. Endocr., 18, 586. Nelson. D. H., Meakin, S. W., and Thorn, G. W. (1960). Ann. intern. Med., 52, 560. Plotz, C. M., Knowlton, A. U and Ragan, C. (1952). Amer. J. Med., 13, 597. Siebennmann, R. E. (1955). Schweiz. Z. allg. Path., 18, 1189. Sim, A, W., Hobkirk, R., Blair, D. W., Stewart, H. J., and Forrest, A. P. M. (1961). Lancet, 2, 73. Skrimshire, J. F. P. (1955). Ibid., i, 270. Sprague, R. G. (1953). Proc. roy. Soc. Med., 46, 1070. -Weeks, R. E., Priestley, J. T., and Salassa, R. M. (1961). Modern Trends in Endocrinology, edited by H. Gardiner Hill, p. 84. Butterworths, London. Steiner, J. W., Langer, B., Schatz, D. L., and Volpe, R. (1960). /. exp. Med., ?12, 187.
A new approach to determine parallel conductance for left ventricular volume measurements
Authors: L Kornet
Journal: Cardiovascular Research (2000)

To determine absolute ventricular volume with the conductance catheter technique, the electrical conductance of tissues and fluids (parallel conductance) around the ventricle should be determined precisely.A new objective method to estimate parallel conductance based on analysis of the dilution curve of hypertonic saline was investigated. The parallel conductances obtained with the new method (G(a)(p)) were compared to those obtained with the conventional method (G(l)(p)). The study was performed in the left ventricle of 12 patients.G(a)(p) was not significantly different from G(l)(p). For the G(l)(p) method the average percentage difference between duplicate values, both taken as absolute values, was 15.06% and for the G(a)(p) method it was 4. 01%. Thus the reproducibility of the method is a factor four better than that of the method. This difference appeared to be significant.We conclude that a smaller number of injections will be required to obtain the same precision using our method.
Use of serial exercise tests to assess the efficacy and duration of action of drugs for asthma
Authors: M. Silverman, P. Konig, S. Godfrey, T. Andrea
Journal: Thorax (1973)

<b>Silverman, M., Konig, P., and Godfrey, S. (1973).</b><i>Thorax</i>, <b>28</b>, 574-578. <b>Use of serial exercise tests to assess the efficacy and duration of action of drugs for asthma.</b> A technique for studying the efficacy and duration of action of drugs used in asthma by means of exercise tests is described. The patient runs for six minutes every two hours, four times a day, on a treadmill at a constant speed and slope. The test drug or its placebo is given immediately before the first test of the day, and their effects on the exercise-induced asthma are compared. This enables the immediate protection and duration of action of the test drug to be measured. No change in the severity of post-exercise asthma was found when serial tests were performed during one day after administration of a placebo. In a selected group of 14 children studied with disodium cromoglycate, three patterns were seen. In five patients the drug afforded prolonged benefit, in five others the protection was very short-lived, and in four patients it did not seem to be better than the placebo. The use of the tests is also illustrated with respect to bronchodilator drugs.
Where commerce and health collide
Authors: F. Godlee
Journal: BMJ (2008)

The WHO commission on the social determinants of health (the Marmot report) called for an international framework convention on alcohol like the 2005 framework for tobacco control. In this week’s journal, Robin Room and colleagues add their weight and some detail to this call (doi:10.1136/bmj.a2364). “Alcohol is the only strong psychoactive substance in common use that is not controlled internationally,” they say in their editorial. A framework convention would put constraints on international trade in alcohol, particularly on cross border trafficking, and would be a call for action, encouraging governments to implement evidence based policies within their own borders.

There’s no shortage …
Tension-free repair versus Bassini technique for strangulated inguinal hernia: A controlled randomized study
Authors: Magdy M.A. Elsebae, Maged Nasr, Mohamed Said
Journal: International Journal of Surgery (2008)

By Evidence Based Medicine (EBM) principles, several meta-analyses concluded that use of mesh is superior to the non-mesh operations in inguinal hernia surgery. Wound infection is a potential complication of all hernia repairs and deep-seated infection involving an inserted mesh may result in chronic groin sepsis. In the event of incarcerated or strangulated hernias, however; placement of prosthetic material is presumed to increase that risk of infection.Aim of the study is to compare the outcome of tension-free mesh repair to Bassini technique used to treat strangulated inguinal hernia.In the period from May 2004 to December 2006, 54 patients were submitted to emergency operation because of strangulated inguinal hernia. The patients were randomized into two groups (27 patients in each group). Group A patients underwent open tension-free anterior repair utilizing a monofilament polypropylene mesh according to Lichtenstein "tension-free" technique, whereas group B patients underwent Bassini technique. Mesh hernioplasty was not attempted in patients with preoperative peritonitis, inflammatory hernia and for those in whom bowel resection was perfumed for ischemic necrosis caused by strangulated inguinal hernia and they were excluded from the study. Assessment of the primary outcome included surgical complications and hospital stay and secondary outcome was the recurrence of hernia.Postoperative complication rate did not differ significantly between the two groups. Postoperative hospital stay was also significantly longer in group B compared to group A (5+/-3.4 days versus 3+/-2.1 days, p<0.01). During the follow-up, (mean 22+/-6months), three patients had recurrence after Bassini operation (group B), but there was no recurrent hernia after mesh herniorrhaphy (group A) (0/27=0% versus 3/27=7, 11.1%, p<0.001).The use of Lichtenstein "tension-free" technique in emergency treatment of strangulated inguinal hernia is safe, effective with an acceptably low rate of postoperative complications and without recurrence.