tbuckley/cabot-search huggingface dataset:
Polycythemia Vera in Acromegaly
Authors: Pascale Grellier
Journal: Annals of Internal Medicine (1997)

Letters1 January 1997Polycythemia Vera in AcromegalyPascale Grellier, MD, Philippe Chanson, MD, and Gilbert Schaison, MDPascale Grellier, MDHopital Bicetre; 94275 Kremlin-Bicetre, FranceSearch for more papers by this author, Philippe Chanson, MDHopital Bicetre; 94275 Kremlin-Bicetre, FranceSearch for more papers by this author, and Gilbert Schaison, MDHopital Bicetre; 94275 Kremlin-Bicetre, FranceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-1-199701010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Teramoto and Ouchi point out that the complete remission of polycythemia vera that we saw in a patient after the surgical cure of acromegaly could have been partly caused by remission of hypoxemia in relation to obstructive sleep apnea. Obstructive sleep apnea, which is a common complication of acromegaly, can lead to polycythemia through the hypoxemia it produces. However, some of our patient's findings led us to believe that hypoxemia was not involved in the pathogenesis of polycythemia.Even if the erythropoietin level is not specific for diagnosing polycythemia vera [1], polycythemia secondary to hypoxemia is usually associated ...References1. Casadevall N, Lacombe C, Varet B. Erythroid cultures and erythropoietin assay. Clinical and diagnosis value. Nouv Rev Fr Hematol. 1990; 32:77. Google Scholar2. Lacombe C, Casadevall N, Varet B. Polycythemia vera: in vitro studies of circulating erythroid progenitors. Br J Haematol. 1980; 44:189-99. Google Scholar3. Partanen S. Spontaneous erythroid colony formation in erythrocytocis. Scand J Haematol. 1982; 29:319-24. Google Scholar Author, Article, and Disclosure InformationAuthors: Pascale Grellier, MD; Philippe Chanson, MD; Gilbert Schaison, MDAffiliations: Hopital Bicetre; 94275 Kremlin-Bicetre, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1997Volume 126, Issue 1Page: 87KeywordsAcromegalyErythropoietinHypoxiaPathogenesisPolycythemiaPolycythemia veraPulse oximetrySleep apneaSurgery ePublished: 15 August 2000 Issue Published: 1 January 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Pregnancy‐related thrombosis in a woman with congenital afibrinogenemia: A report of two successful pregnancies
Authors: H. Roqué, C. Stephenson, M.J. Lee, E.F. Funai, D. Popiolek, E. Kim, D. Hart
Journal: American Journal of Hematology (2004)

Abstract We managed two pregnancies in a woman with congenital afibrinogenemia with increasing amounts of cryoprecipitate to achieve a pre‐infusion fibrinogen level of 60 mg/dL. The first pregnancy resulted in placental abruption at 36 weeks, in spite of recent cryoprecipitate infusion. Both placentas showed infarction. Post‐partum ovarian and renal vein thromboses complicated the second pregnancy. Mean FVIII (344%) and vWF Antigen (323%) were elevated prior to cryoprecipitate infusion, with mean post‐infusion levels of 367% and 363%. The clearance of fibrinogen after cryoprecipitate infusion increased during the course of pregnancy. A paradoxical prothrombotic state with embolization may play a role in the observed complications of pregnancy. Am. J. Hematol. 76:267–270, 2004. © 2004 Wiley‐Liss, Inc.
Lung blood flow studies in patients with scoliosis and neuromuscular weakness
Authors: W. A. Littler, S. R. Reuben, D. J. Lane
Journal: Thorax (1973)

Pulmonary capillary blood flow was measured by the nitrous oxide body plethysmograph technique in 16 patients, 10 of whom had scoliosis and six neuromuscular weakness. A linear correlation was found between the pulmonary artery to capillary flow conduction time and Pao<sub>2</sub> (r=+0·85; p&lt;0·001). The finding of a reduced flow conduction time and its correlation with the Pao<sub>2</sub> suggests the presence of pulmonary arterial hypertension presumably on the basis of active vasoconstriction.
CHOLESTEROL SYNTHESIS AND HYPERCHOLESTEROLEMIA
Authors: F. William Sunderman
Journal: JAMA (1926)

InThe Journal, Oct. 3, 1925, page 1066, an editorial appears entitled "The Synthesis of Cholesterol in the Body." It is indicated therein that feeding experiments have shown that cholesterol need not have its source exclusively in the diet. We submit further evidence on this point in the form of Dezani's work (<i>Arch. di farmacol. sper.</i><b>12</b>:4, 1914). He fed measured quantities of cholesterol to white mice, and on analyzing their entire carcasses, found that the total amount of cholesterol therein was greater than what could be explained on the basis of that ingested. The subject of cholesterol synthesis comes to medical men by various avenues. Foremost among these are the various considerations associated with hypercholesterolemia, in connection with which certain tissue changes may come about or be experimentally induced. Some, notably the atheromatous aortas of rabbits, have been repeatedly and rather uniformly elicited, but others, such as xanthoma
Particle-based transcutaneous administration of HIV-1 p24 protein to human skin explants and targeting of epidermal antigen presenting cells
Authors: Fiorenza Rancan, Sarah Amselgruber, Sabrina Hadam, Sevérine Munier, Vincent Pavot, Bernard Verrier, Steffen Hackbarth, Behazine Combadiere, Ulrike Blume-Peytavi, Annika Vogt
Journal: Journal of Controlled Release (2014)
Fat composition may be a clue to explain the primary therapeutic effect of enteral nutrition in Crohn's disease: results of a double blind randomised multicentre European trial
Authors: M A Gassull, F Fernandez-Banares, E Cabre, M Papo, M H Giaffer, J L Sanchez-Lombrana, C Richart, H Malchow, F Gonzalez-Huix, M Esteve
Journal: Gut (2002)

Dietary fat has been suggested to determine the therapeutic effect of enteral diets in Crohn's disease.To assess the efficacy of two whole protein based diets with different fat compositions (n6 polyunsaturated fatty acids v monounsaturated fatty acids) in inducing clinical remission in active Crohn's disease compared with steroids.Sixty two patients with active Crohn's disease were randomised to receive, for not more than 4 weeks: (a) a polymeric enteral diet containing 35 g of lipids per 1000 kcal, high in oleate (79%) and low in linoleate (6.5%) (PEN1), (b) an identical enteral diet except for the type of fat which was high in linoleate (45%) and low in oleate (28%) (PEN2), or (c) oral prednisone (1 mg/kg/day). Diets were double blindly administered. The steroid group received a conventional ward diet. Treatment failure was considered when remission was not achieved at week 4. Clinical activity and biological and nutritional parameters were monitored. Independent predictors of remission were identified by stepwise logistic regression analysis.Overall remission rates (by intention to treat) were 20% (4/20) for PEN1, 52% (12/23) for PEN2, and 79% (15/19) for steroids (overall p=0.001; p<0.0005 steroids v PEN1, and p=0.056 PEN2 v PEN1). After excluding those patients who were non-compliant during the first week (per protocol analysis), remission rates were 27%, 63%, and 79%, respectively (p=0.008, steroids and PEN2 v PEN1). After adjusting for confounding variables, PEN1 remained significantly associated with a poor response.The type of dietary fat may be of importance for the primary therapeutic effect of enteral nutrition in active Crohn's disease.
Bartter's Syndrome: Urinary Prostaglandin E-like Material and Kallikrein; Indomethacin Effects
Authors: PERRY V. HALUSHKA
Journal: Annals of Internal Medicine (1977)

The urinary excretions of prostaglandin E-like material (iPGE) and kallikrein were measured in two children with Bartter's syndrome. Urinary iPGE excretion was three and 10 times greater than normal, and urinary kallikrein was five and 10 times greater than normal in the two subjects. Furthermore, excretions of iPGE and kallikrein were highly correlated (P < 0.005) with each other before and during treatment with indomethacin, a prostaglandin synthetase inhibitor. Indomethacin significantly (P < 0.001) reduced urinary iPGE, urinary kallikrein, and plasma renin activity, while increasing the sensitivity to intravenous angiotensin II and the serum potassium to normal. The results confirm that renal prostaglandins may be involved in the pathogenesis of Bartter's syndrome and suggest that renal prostaglandins and the kallikrein-kinin system are linked.
Intimal Tear Without Hematoma
Authors: Lars G. Svensson, Sherif B. Labib, Andrew C. Eisenhauer, John R. Butterly
Journal: Circulation (1999)

The modern imaging techniques of transesophageal echocardiography, CT, and MRI are reported to have up to 100% sensitivity in detecting the classic class of aortic dissection; however, anecdotal reports of patient deaths from a missed diagnosis of subtle classes of variants are increasingly being noted.In a series of 181 consecutive patients who had ascending or aortic arch repairs, 9 patients (5%) had subtle aortic dissection not diagnosed preoperatively. All preoperative studies in patients with missed aortic dissection were reviewed in detail. All 9 patients (2 with Marfan syndrome, 1 with Takayasu's disease) with undiagnosed aortic dissection had undergone >/=3 imaging techniques, with the finding of ascending aortic dilatation (4.7 to 9 cm) in all 9 and significant aortic valve regurgitation in 7. In 6 patients, an eccentric ascending aortic bulge was present but not diagnostic of aortic dissection on aortography. At operation, aortic dissection tears were limited in extent and involved the intima without extensive undermining of the intima or an intimal "flap." Eight had composite valve grafts inserted, and all survived. Of the larger series of 181 patients, 98% (179 of 181) were 30-day survivors.In patients with suspected aortic dissection not proven by modern noninvasive imaging techniques, further study should be performed, including multiple views of the ascending aorta by aortography. If patients have an ascending aneurysm, particularly if eccentric on aortography and associated with aortic valve regurgitation, an urgent surgical repair should be considered, with excellent results expected.
Severe Islet Amyloidosis in Congenital Generalized Lipodystrophy
Authors: Abhimanyu Garg, Manisha Chandalia, Frank Vuitch
Journal: Diabetes Care (1996)

Islet amyloidosis may be one mechanism for pancreatic islet beta-cell loss that is associated with the development of NIDDM. However, the question remains whether chronic overstimulation of insulin and islet amyloid polypeptide (IAPP) secretion in states of insulin resistance could lead to formation of islet amyloidosis and hence NIDDM in some patients. We studied pancreatic islet pathology in congenital generalized lipodystrophy, a genetic syndrome of extreme insulin resistance that may provide some clues.Our patient was a 24-year-old African-American woman with congenital generalized lipodystrophy. Severe acanthosis nigricans was noted in her since age 6. At ages 12 and 16, normal and impaired glucose tolerances, respectively, were noted on oral glucose tolerance tests but were accompanied by extreme fasting and post-prandial hyperinsulnemia. Overt diabetes developed at age 18 and she required approximately 180 U of insulin daily. Immediately after an accidental death at age 24, an autopsy was performed. Pancreatic histology was studied in detail using routine methods and immunohistochemical techniques.Some scarring of the pancreas as a result of previous episodes of acute pancreatitis was observed. Severe amyloidosis was noted in 89% of the islets, sparing those that were rich in pancreatic polypeptide-secreting cells. Amyloid deposits stained intensely on immunostaining with antibodies against amylin. Marked paucity of beta-cells was evident. The ratio of beta- to alpha-cells was reduced to 1:1 (normal ratio approximately 4:1).These observations suggest that chronic presence of extreme insulin resistance may induce premature and severe islet amyloidosis as well as beta-cell atrophy.
Modulation of hemodynamics and organ blood flow by nitric oxide synthase inhibition is not altered in normotensive, septic rats.
Authors: C M Martin, W J Sibbald
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Hyperdynamic sepsis is associated with a redistribution of organ blood flow. We hypothesized that increased nitric oxide (NO) production could mediate this process. The objective of this study was to determine the effect of a NO synthesis inhibitor on systemic and organ blood flows in vivo in septic and in normal rats. Rats were instrumented for hemodynamic monitoring and randomized to undergo cecal ligation and perforation (CLP) or control laparotomy. Cardiac output and organ blood flow were measured by thermodilution and radioactive microspheres, respectively. Baseline values were obtained at 24 h after CLP or control laparotomy and after the administration of L-nitro-arginine methyl ester (L-NAME) at 2, 4, 8, and 16 mg/kg intravenously. All studies were performed in awake, unrestrained animals. Septic animals were normotensive and hyperdynamic. L-NAME decreased cardiac index and increased systemic vascular resistance and mean arterial blood pressure to an equivalent degree in control and in CLP animals. CLP was associated with significantly increased relative blood flow to the small bowel and portal circulation. Although cardiac output decreased with L-NAME, blood flow to the diaphragm, liver, and brain was relatively well preserved. Absolute blood flow to other organs, including small bowel, decreased in parallel to the cardiac output. The effect of L-NAME on organ blood flow was comparable in control and in CLP animals. We conclude that the influence of NO on organ blood flows appears to vary between organs, but that NO does not explain the redistribution of blood flow observed in hyperdynamic sepsis.
The World of Asclepios: A History of Medicine in Objects
Authors: Lester S. King
Journal: JAMA (1964)

The medical museum is a relatively uncommon institution, but when well-ordered can provide a fascinating cultural and educational experience. Although in the past the term "museum" has often held a dull, musty connotation, this image is fortunately changing. In Zurich, The Institute of the History of Medicine, where Professor Ackerknecht is director, has an outstanding museum, which demonstrates that a history of medicine can find effective expression in objects of historical import. From this museum Dr. Ackerknecht presents a thoughtful selection of medical objects, art works, portraits, archeological findings, instruments, that together sketch out a panorama of medical history. The photographic reproductions are excellent, and many of the plates are in splendid color. A brief text, in both German and English, provides a continuity and exposition. The author's careful selection presents a surprisingly comprehensive view in a small compass. The book is not a history of medicine. It is a
<i>ARLTS1</i> Trp149Stop Mutation and the Risk of Ovarian Cancer
Authors: Bartłomiej Masojć, Krzysztof Mędrek, Tadeusz Dębniak, Jan Lubiński, Lucjan S. Wyrwicz, Grzegorz Koczyk, Marcin Hoffmann, Leszek Rychlewski
Journal: Cancer Research (2007)

To the Editor: 

In a recent report, Petrocca et al. ( [1][1]) provided data on involvement of the ARLTS1 ( ARL11 ) gene alterations in development of both ovarian and breast cancers. The authors clearly showed the tumor-suppressor function of ARLTS1 in ovarian cancer and the biological importance
Hostility and the heart
Authors: M. C Whiteman, F G. R Fowkes, I. J Deary
Journal: BMJ (1997)

The links between personality and coronary heart disease have challenged investigators ever since Friedman and Rosenman first suggested that the disease was more common among people with a type A personality—time pressured, competitive, and aggressive.1 The research has tried to improve clinicians' ability to predict who is most vulnerable to coronary heart disease and so to identify people who are most likely to benefit from prevention measures. One result of this research was recently summarised in a meta-analysis by Miller et al which showed that hostility is an independent risk factor for coronary heart disease.2

Hostility is a broad concept. It has connotations of anger, aggression, and a chronic negative outlook and so encompasses feelings, overt actions, and thoughts or attitudes.3 The cognitive components (those involving thoughts and attitudes) may include cynicism or mistrust, a desire to oppose others, or a wish to do them harm.4 A distinction should be drawn between the experience of hostility and its expression.5 The experience of …
Increased protein intake augments kidney volume and function in healthy infants
Authors: Joaquin Escribano, Veronica Luque, Natalia Ferre, Marta Zaragoza-Jordana, Veit Grote, Berthold Koletzko, Dariusz Gruszfeld, Piotr Socha, Elena Dain, Jean-Noel Van Hees, Elvira Verduci, Ricardo Closa-Monasterolo
Journal: Kidney International (2010)
Lo, the Poor Indian!
Authors: Alexander Pope
Journal: JAMA (1970)

In his essay, "The Navajo," (p 17) Irvine has presented a bleak picture of Indian reservation life. The growing Navajo population suffers poverty, educational deficiency, miserable housing, little or no sanitation, a high rate of infant mortality, malnutrition, and a prevalence of illnesses that elsewhere have declined. According to another source, there are about 650,000 American Indians in the United States today, and less than one third of them have moved away from reservations into cities (<i>The New York Times Encyclopedic Almanac, 1970</i>). Father Peter Powell, director of St. Augustine's Center, Chicago, estimates that there are some 15,000 American Indians in that city. Representatives of as many as 50 different tribes may arrive in a month. Although families are scattered throughout the city, most of them are concentrated at the north side. Some of the young city dwellers have an air of militancy, but the greater part of the population
THE AESTHETICS OF MEDICINE
Authors: C. J. Macalister
Journal: BMJ (1913)

IT iS curious tonote hlow shbort-lived tcte meem-ory of some evil things mlay be.Whien we suffer bereavemiienit, ti-e softens ou1r sorrows and d we comn e to look back with equqanimyity upon the aniguishi whichic we suffered -at the time of disease or disaster and death, and only the hiappy memories associated withi life remain.In the case of niations whichli hiave been at war the tragedies anid calamities and anixieties incidental to the period of hostility after a time become miere matters of talk.Thl e sense of reality which surrouonded them at the time of their occurrence is lost and they are looked back upponi wituouLit emotion.As in the ease of all friendshiips whiichc hiave been seriously broken and patched up again, scars of iistrust and of enmiity rem ain on eiteihe side and it is doutbtfful wvhetlier they cani be effaced, at all events in thle lifetimle of a generation.Fortunately, hlowever, these scars are not iecessarily transmitted to the d(lescendaiits of the prieviouisly hostile i-aces; just as the childreni of disfiguLred parents are born withiout blemei ishl , the old animosities becomie smoothed away and, an entenmle cordiale being established, nations wlhich were formeerly ilenemies may becomue fast friends.It is coimimo knowledge that the lessonis of a war are soon forgotten, all the enithusiasm whichcl existedl at the time of the e war aboutt havingc territorial regiments up to strengthi disappears, anid instead of hiavinig to i-eject nen because there is no room for thlelm-the young miianh'ood of the country lapses into its old condition of indifference and carelessness, and all kiinds of schnemes and projects hlave to be formlulated and emmployed to enCcourage recruiting and to imppress thle ecessity for tarainingi anid readiness in case of emer-gency.Just as in the case of a war, the memory of a scourge which, , passinga over a coutntry,kIills thousands of people, soon goes; a decade passes, and the remenmbrancc.s of the sore experienes become softened, and people liaving resuledthelir norlmial chleerfulness and optimilismi , think, if they (lo not say, "Sufficient unto the day is tlhc evil thlereof.'A gelneration passes, anid the nevw one regards the story of wvoe as a miatter of Iiistori-interest, worryign1o doubt to their ancestors, but whly trotuble about a set of people whloml they onily knew by liealsay, or abouit a disease wlich is little likely to becomiie epidemic again in view of all the precauitions whliclh the lhealtlh au:thorities under talie to keep it in cleeck?A lnation's gratitude is ofteni periodically revived by the celebrationi of tlle anlliversalies of gi-eat historic battles and militar-y evenits-for instanic.b)y the
Abstract 1932: Phenylmethimazole decreases constitutively high basal levels of Interleukin 6 (IL-6) in a triple negative breast cancer cell line
Authors: John D. O'Brien, Douglas J. Goetz, Anuja Alapati, Sudhir P. Deosarkar, Leonard D. Kohn, Kelly D. McCall
Journal: Cancer Research (2012)

Abstract Interleukin 6 (IL-6) is a pro-inflammatory cytokine that plays an important role in the progression of many types of cancers by regulating macrophage recruitment and differentiation, as well as modulating the activation of the JAK/Stat signal cascade, and inducing pro-angiogenic factors. Several studies have correlated a negative prognosis in cancer with a high level of IL-6 in patient serum. Triple (i.e. progesterone, human epidermal growth factor-2, and estrogen receptor) negative breast cancer has been reported to be highly aggressive and invasive. MDA-MB-231, a triple negative breast cancer cell line, expresses high basal levels of IL-6. Recently our laboratory demonstrated that phenylmethimazole (C10), a novel toll-like receptor inhibitor, diminishes basal expression of IL-6 in pancreatic cancer and melanoma cells as well as their growth and migration. Based on these observations, we sought to test the hypothesis that C10 inhibits IL-6 expression in MDA-MB-231 cells. Here we report that triple negative breast cancer cells express considerably higher levels of IL-6 than estrogen receptor positive breast cancer cells and that C10 significantly reduces IL-6 expression in the triple negative breast cancer cells. This inhibition was observed at both the RNA and protein level. Given the importance of IL-6 in cancer progression, and our finding that C10 attenuates IL-6 expression in the MDA-MB-231 cell line, this study suggests that C10 may have therapeutic potential for triple negative breast cancers. Additional studies are currently underway to further explore these hypotheses. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1932. doi:1538-7445.AM2012-1932
A COMBINED UTERINE IRRIGATOR AND DRAINAGE TUBE, WITH INDICATIONS FOR ITS USE.
Authors: O. GROTHAN
Journal: JAMA (1895)

The need of uterine drainage as based upon modern surgical principles is or ought to be so well understood that anything said in this direction may seem as though treading on already well beaten grounds. Yet the importance of the subject will bear repeating, even though we have good reason to expect these indications to become fewer and fewer, as time goes on, hand in hand with aseptic obstetrics and gynecology. Still there is one thing certain, that until we may live in a Utopia of a sterilized medical profession and absolute cleanly patients, the dirty doctor (I mean surgically dirty) and ignorant midwife will always be with us, and leave infection along their wake. Beside, an infected womb of ten or fifteen years ago, may at any time, cost our patient the price of her life, irrespective of the law of established tolerance. The indication for uterine drainage and