tbuckley/cabot-search huggingface dataset:
Congenital Dislocation of the Hip
Authors: Robert E. Eilert
Journal: JAMA (1983)

This is a multiauthor book, the outgrowth of the Pediatric Orthopedic International Seminars, which Dr Tachdjian has organized for the past seven years. The stated goal of producing a reference volume has been accomplished. The scope is comprehensive, including the views of an international group of 44 distinguished authors representing 11 countries. The entire spectrum of problems associated with congenital dislocation of the hip is covered, including anatomy, diagnosis, nonoperative treatment, open reduction, femoral osteotomies, pelvic osteotomies, complications, and salvage procedures. There is some overlap and difference of opinion among the authors, which strengthens the book as a reference but may confuse the novice. New, unpublished information is presented, so that the book is more than a collection of previously published papers. This is especially true for material from Germany and Japan not available in English. The book is well edited, being organized according to the age of the patient
Interleukin 2 receptor expression in unstimulated murine splenic T cells. Localization to L3T4+ cells and regulation by non-H-2-linked genes.
Authors: H Kawamura, S O Sharrow, D W Alling, D Stephany, J York-Jolley, J A Berzofsky
Journal: The Journal of Experimental Medicine (1986)

The present study reports the surprising observation that IL-2-R+ cells can be detected in fresh, unstimulated, murine spleen T cells from unimmunized mice by flow cytometry using the monoclonal anti-receptor antibody 7D4. Also, unexpectedly, these cells were found exclusively in the L3T4+Lyt-2- population by two-color fluorescence, in contrast to receptor+ cells after stimulation, in which both L3T4+Lyt-2- and Lyt-2+L3T4- cells were found. The fraction of splenic T cells bearing IL-2-R reproducibly varies twofold under non-H-2-linked genetic control, with high expression in DBA/2 and BALB/c (approximately 6-7%) and low expression in B10.D2 and C57BL/6 (3%). This correlates quantitatively with a greater responsiveness of the DBA/2 and BALB/c splenic T cells to high doses of IL-2, compared with B10.D2 T cells; twice as many B10.D2 T cells as DBA/2 T cells were required to get the same response. Studies with 23 B X D RI strains revealed that the level of IL-2-R+ cells in unstimulated spleen cells was regulated by multiple genes, very likely including at least one gene on chromosome 7, near the HBB locus. The mapping makes novel use of nonparametric (Smirnov) statistics, which we suggest may be of general usefulness in similar analyses of RI strains.
Quantification of wound oedema after dermatological surgery
Authors: E.J. McGrath, P. Kersey
Journal: British Journal of Dermatology (2009)

Postoperative wound oedema causing increased suture tension is thought to be a possible cause of scars known as suture marks. Quantification of such oedema has not previously been reported in the literature. Measures to accommodate wound oedema may include the adoption of alternative suture techniques and the use of more elastic suture materials.To quantify wound expansion after skin surgery and to identify any contributory factors, and to determine the ability of eight commonly used skin suture materials to stretch under increasing tension.Forty consecutive adult patients attending a dermatology department for routine skin surgery in December 2002 were recruited. Details including body site, nature of the lesion excised and dimensions of the open wound were recorded. The distance between entry and exit points of an untied suture at the time of skin surgery was measured and then repeated 24 h postoperatively. The ability of eight different suture materials to stretch when an increasing force was applied was measured by hanging standard weights from the sutures and measuring the suture length for each force applied.Thirty-nine patients completed the study. All wounds expanded postoperatively, with a mean lateral expansion of 1.0 mm. There was a strong association between the width of the unsutured wound after excision and the subsequent wound expansion. Commonly used sutures in skin surgery were found to be relatively inelastic at forces under 0.2 kg. The monofilament Novofil (Davis & Geck, Danbury, CT, U.S.A.) exhibited the greatest degree of stretch of those tested.There is considerable oedema in the first 24 h after skin surgery, particularly with wider excisions. This needs to be considered when choosing suturing materials and techniques to avoid excessive suture tension.
Effects of the National Health Service on Physician Utilization and Health in England and Wales
Authors: William H. Stewart, Philip E. Enterline
Journal: New England Journal of Medicine (1961)

ON July 5, 1948, the National Health Service was put into operation in England and Wales. This is a Government-sponsored, tax-supported plan to provide complete medical, dental and nursing care to all persons without direct charge.One of the reasons for the National Health Service (NHS) was the belief that people were not getting the kinds of medical and hospital care that they required, owing in part to the inability of certain segments of the population to pay for such care.1 In view of current interest in the United States in economic barriers to medical care, it seems instructive to . . .
A new apparatus for detection of impending pacemaker failure in patients treated with implanted pacemakers
Authors: L. Ryden, P. Hedstrom, S. Leijonhufvud
Journal: Cardiovascular Research (1970)

Technical description of a device intended for prophylactic checking of implanted capacitor discharge pacemakers is given. Rate, leading edge amplitude, impulse duration, and time constant are displayed in digital form. The apparatus can be used to investigate pacing failure as well as basic property of a pacemaker which has not been implanted.
National Asthma Education and Prevention Program Working Group Report on the Quality of Asthma Care
Authors: Linda Headrick, Ellen Crain, David Evans, Morgan N. Jackson, Barbara H. Layman, Robert M. Bogin, Mark Young, Kevin B. Weiss
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

The financing of asthma care is the third topic of the National Asthma Education and Prevention Program Task Force Report on the Cost Effectiveness, Quality of Care, and Financing of Asthma Care. This working group explored the effects of financing on access to services, treatment of asthma, and potential health outcomes. Over the course of a year, the working group collected and analyzed information pertaining to the various types of public and private health care financing mechanisms, including both insurance-based and non-insurance-based issues. The group examined the published literature and gathered information from four public hearings conducted across the nation. The result of this synthesis of information on health care financing and asthma care is a set of 12 recommendations that seek to improve the financing of asthma care.
Holiday Gynecomastia Related to Marijuana?
Authors: Kenneth R. Dardick
Journal: Annals of Internal Medicine (1993)

Letters1 August 1993Holiday Gynecomastia Related to Marijuana?Kenneth R. Dardick, MDKenneth R. Dardick, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-3-199308010-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Heufelder and colleagues [1] reported a case of gynecomastia in a patient who had vacationed in the Virgin Islands. They speculated on the possible contribution of heavy alcohol intake or estrogenized chicken as the cause of this syndrome. Another possible contributing factor, which has been previously reported [2, 3], could be heavy marijuana use.References1. Heufelder AE, Leinung MC, Northcutt RC. Holiday gynecomastia. Ann Intern Med. 1992; 116:877. Google Scholar2. Harmon J, Aliapoulios MA. Gynecomastia in marijuana users. N Engl J Med. 1972; 287:936. Google Scholar3. Harmon JW, Aliapoulios MA. Marijuana-induced gynecomastia: clinical and laboratory experience. Surgical Forum. 1974; 25:423-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Kenneth R. Dardick, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMucocutaneous manifestations of illicit drug useDrugs of AbusePossible Role of Marijuana Smoking as a Carcinogen in the Development of Lung Cancer at a Young Age 1 August 1993Volume 119, Issue 3Page: 253KeywordsAddictionAlcoholsEstrogensMarijuana ePublished: 15 August 2000 Issue Published: 1 August 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Idiopathic myelofibrosis: A clinical study of 80 patients
Authors: Hans Hasselbalch
Journal: American Journal of Hematology (1990)

Abstract A series of 122 consecutive patients with bone marrow fibrosis initially referred or categorized as idiopathic myelofibrosis is described. After a clinical and pathological review 14 patients were classified as postpolycythaemic myelofibrosis and 7 patients as a transitional myeloproliferative disorder. In 13 patients a diagnosis of hairy cell leukaemia was made, 3 patients had malignant tymphoma, 2 had malignant histiocytosis, and 1 patient had systemic lupus erythematosus with myelofibrosis. Two patients were excluded for further analysis owing to insufficient data. In the remaining 80 patients a diagnosis of idiopathic myelofibrosis was made. The clinical and laboratory findings in this series of patients are presented and compared to those in previous series. Infectious, cardiovascular, thromboembolic, and haemorrhagic complications were frequent, being recorded in 63%, 50%, 40%, and 33% of the patients, respectively. Various autoimmune phenomena were found in a proportion of the patients, but none had clinical evidence of connective tissue disease. Fifteen patients (19%) had a syndrome of acute myelofibrosis. The diagnostic criteria for this disease entity and its place within the spectrum of myeloproliferative disorders are discussed. In the present series acute myelofibrosis was found to encompass various transitional stages toward the evolution of acute leukaemia. It is proposed that acute or malignant myelofibrosis is considered as an acute variant of idiopathic myelofibrosis. Within this syndrome the acute variant seems to be far more common than previously recognized, which may also explain the marked clinical heterogeneity of the myelofibrosis/osteomyelosclerosis syndrome in this and most previous series.
Study helps explain relation between heart disease and insulin resistance
Authors: S. Gottlieb
Journal: BMJ (2002)

High blood concentrations of a naturally occurring compound involved in blood vessel function may help explain why patients with insulin resistance have a high risk of developing heart disease, a study shows.

The study's findings also indicate that drugs that improve insulin sensitivity may reduce levels of the compound, asymmetric dimethylarginine (ADMA), and ultimately reduce a person's risk of developing heart disease ( JAMA 2002;287:1420-6, 1451-2).

Increased cardiovascular risk in diabetes is long believed to be related to dysfuntion of the endothelium in intact blood vessels. The …
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
Authors: P.K. Epling-Burnette, Jin Hong Liu, Robyn Catlett-Falcone, James Turkson, Marc Oshiro, Ravi Kothapalli, Yongxiang Li, Ju-Ming Wang, Hsin-Fang Yang-Yen, James Karras, Richard Jove, Thomas P. Loughran
Journal: Journal of Clinical Investigation (2001)

Large granular lymphocyte (LGL) leukemia is characterized by the expansion of antigen-activated cytotoxic T lymphocytes. These leukemic cells are resistant to Fas-mediated apoptosis despite expressing high levels of Fas. We found that leukemic LGL from 19 patients displayed high levels of activated STAT3. Treatment of leukemic LGL with the JAK-selective tyrosine kinase inhibitor AG-490 induced apoptosis with a corresponding decrease in STAT-DNA binding activity. Moreover, using an antisense oligonucleotide approach to diminish STAT3 expression, we found that Fas sensitivity was restored in leukemic LGL. AG-490–induced apoptosis in leukemic LGL was independent of Bcl-xL or Bcl-2 expression. However, we found that the Bcl-2–family protein Mcl-1 was significantly reduced by AG-490 treatment. Activated STAT3 was shown to bind an SIE-related element in the murine mcl-1 promoter. Using a luciferase reporter assay, we demonstrated that v-src overexpression in NIH3T3 induced STAT3-dependent transcriptional activity from the mcl-1 promoter and increased endogenous Mcl-1 protein levels. We conclude that STAT3 activation contributed to accumulation of the leukemic LGL clones. These findings suggest that investigation should focus on novel strategies targeting STAT3 in the treatment of LGL leukemia.
Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury
Authors: Francisco Javier Cubero, Gang Zhao, Yulia A. Nevzorova, Maximilian Hatting, Malika Al Masaoudi, Julien Verdier, Jin Peng, Frederik M. Schaefer, Nadine Hermanns, Mark V. Boekschoten, Christoph Grouls, Nikolaus Gassler, Fabian Kiessling, Michael Muller, Roger J. Davis, Christian Liedtke, Christian Trautwein
Journal: Journal of Hepatology (2014)
Premier 'Smokeless Cigarettes' Can Be Used to Deliver Crack
Authors: Edward J. Cone, Jack E. Henningfield
Journal: JAMA (1989)

<h3>To the Editor.—</h3> The recent commercial introduction into the US market of the Premier "smokeless cigarette" by R. J. Reynolds Tobacco Company is the newest entry by the tobacco industry of nicotine delivery systems. The device is a tube that has the superficial appearance of a conventional cigarette but that contains very little tobacco.<sup>1</sup>Its primary means of nicotine delivery is an aluminum cylinder in which a charcoal tip has been partially inserted. The cylinder (4.5 mm in diameter and 29 mm in length) is filled with aluminum oxide beads that have been treated with glycerol and nicotine-laden substances. The smoker ignites the charcoal tip and draws hot gases through the aluminum chamber, causing volatile components to form an aerosol and be drawn into the user's lungs. A patent (No. 4756318) application by the company claims that the device "may be used or may be modified for use as
Evidence grows for benefits of exercise in dementia
Authors: Z. Kmietowicz
Journal: BMJ (2013)

Reviewers have found more evidence that exercise can benefit people with dementia by improving their cognitive functioning and ability to carry out everyday activities.

But exercise did not improve symptoms of depression or challenging behaviour in people with dementia, and more evidence is needed to understand how exercise might reduce the burden on carers and health systems, says the Cochrane systematic review.1

In 2008, when the reviewers previously analysed the evidence on exercise and dementia, just four trials met the inclusion criteria for meta-analysis. In the latest review 16 studies with 937 participants met the criteria, although …
Relapse Following Marrow Transplantation for Acute Leukemia
Authors: David T. Harrison, Nancy Flournoy, Robert Ramberg, Cheryl Boyd, Kathy Erne, C. Dean Buckner, Alexander Fefer, Jean E. Sanders, Rainer Storb, E. Donnall Thomas
Journal: American Journal of Hematology (1978)

Abstract One‐hundred‐thirty‐six patients who underwent marrow transplantation for endstage acute leukemia were studied with respect to factors that might predict failure to eradicate or recurrence of leukemia following transplantation. One‐hundred‐five patients were recipients of allogeneic and 31 recipients of syngeneic marrow. Sixty‐four patients had acute lymphoblastic leukemia (ALL) and 72 acute nonlymphoblastic leukemia (ANL). The frequency of persistence of leukemia and relapse was 35% for patients with ANL and 44% for those with ALL. When all the patients are considered as one group pretransplant factors considered simultaneously through proportional hazards modeling showed only the WBC at admission for transplantation to be significant (P = 0.02). The presence of an enlarged spleen, either at diagnosis or at transplantation, was associated with an increased probability of relapse (P &lt; 0.006) among patients with ANL. In patients with ANL. In patients with ALL, active central nervous system (CNS) disease at the time of transplantation significantly increased the risk of relapse in the CNS (P &lt; 0.01). Patients with a white blood cell (WBC) count greater than 20, 000/mm 3 at admission for transplantation had an increased rate of relapse (P &lt; 0.003). Patients whose leukemic cells showed a karyotypic abnormality on cytogenetic analysis had an increased probability of relapse as compared to those with karyotypically normal leukemic cells (P = 0.04). Following transplantation, the persistence of leukemic cells in the marrow one week after transplantation indicated an increased likelihood of failure to achieve remission and an increased likelihood of subsequent relapse in those who achieved a remission (P &lt; 0.001).
Proliferation and differentiation of highly enriched mouse hematopoietic stem cells and progenitor cells in response to defined growth factors.
Authors: C E Müller-Sieburg, K Townsend, I L Weissman, D Rennick
Journal: The Journal of Experimental Medicine (1988)

Three distinct hematopoietic populations derived from normal bone marrow were analyzed for their response to defined growth factors. The Thy-1loT- B- G- M-population, composing 0.2% of bone marrow, is 370-fold enriched for pluripotent hematopoietic stem cells. The two other populations, the Thy-1- T- B- G- M- and the predominantly mature Thy-1+ T+ B+ G+ M+ cells, lack stem cells. Thy-1loT- B- G- M- cells respond with a frequency of one in seven cells to IL-3 in an in vitro CFU-C assay, and give rise to many mixed colonies as expected from an early multipotent or pluripotent progenitor. The Thy-1- T- B- G- M- population also contains progenitor cells which responded to IL-3. However, colonies derived from Thy-1- T- B- G- M- cells are almost exclusively restricted to the macrophage/granulocyte lineages. This indicates that IL-3 can stimulate at least two distinct clonogenic early progenitor cells in normal bone marrow: multipotent Thy-1loT- B- G- M- cells and restricted Thy-1- T- B- G- M- cells. Thy-1loT- B- G- M-cells could not be stimulated by macrophage colony-stimulating factor (M-CSF), granulocyte CSF (G-CSF) or IL-5 (Eosinophil-CSF). The hematopoietic precursors that react to these factors are enriched in the Thy-1- T- G- B- M- population. Thus, multipotent and restricted progenitors can be separated on the basis of the expression of the cell surface antigen Thy-1.
Reactivation of Herpes virus hominis (HVH) infection in mice treated with cyclophosphamide and prednisolone sodium phosphate (Codelsol)
Authors: Trevor Robinson, Janice Hurd
Journal: British Journal of Dermatology (1975)

Journal Article Reactivation of Herpes virus hominis (HVH) infection in mice treated with cyclophosphamide and prednisolone sodium phosphate (Codelsol) Get access Trevor Robinson, Trevor Robinson University College Hospital, London WC1 Search for other works by this author on: Oxford Academic Google Scholar Janice Hurd Janice Hurd University College Hospital, London WC1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 93, Issue s11, 1 July 1975, Pages 24–25, https://doi.org/10.1111/j.1365-2133.1975.tb06775.x Published: 01 July 1975
Extracardiac recordings of His-Purkinje activity during conduction disorders and junctional rhythms.
Authors: E J Berbari, R Lazzara, N El-Sherif, B J Scherlag
Journal: Circulation (1975)

Previous investigations have demonstrated a surface recording technique using signal averaging to detect electrical activity during the "isoelectric" P-R segment. Various physiological and pharmacological interventions suggest that the source of these potentials isthe His-Purkinje system (HPS). In order to assess the sensitivity of averaged recordings to changes in HPS activation, i.e., conduction defects in the HPS recordings were made directly from the heart surface using a bipolar, anterior-posterior epicardial lead in 15 dogs which underwent thoractomy. The signal was amplified, filtered and averaged using a digital computer for purposes of signal enhancement. The epicardial averaged lead (EAL) contained activity coincident with HPS depolarization and similar to those recorded by leads on the body surface of intact dogs from previous studies. The standard ECG and His bundle electrogram from an electrode catheter served as references in localizing and assessing several conduction disorders experimentally produced by traumatic and ischemic injury. Among the disorders produced were: 1) atrioventricular (A-V) nodal block which resulted in loss of recorded activity in the EAL following the P wave. 2) First and second degree intra-His bundle block produced by anterior septal artery ligation showed split His potentials in the HBE (1 degree) and 2:1 conduction with block in the His bundle (2 degrees). In the blocked beats the EAL showed a reproducible portion of the activity coincident with proximal His bundle activity of the split His potentials in both cases. 3) In four cases of proximal right bundle branch block produced by anterior septal artery ligation the relatively proximal portions of HPS activity in the EAL showed marked diminution. 4) Two cases of distal His bundle or bilateral bundle branch delay were seen as prolonged H-V time and a normal QRS pattern. The early and late portions of the HPS activity in the EAL were not markedly changed while the middle portion was prolonged and fractionated. 5) Junctional rhythms produced by crushing the SA node resulted in no atrial activity occurring prior to HPS depolarization in the EAL. However, the QRS was preceded by HPS activity whose onset was coincident with the H recorded in the His bundle electrogram. The EAL showed consistent and reproducible morphology and timing of HPS activity at different heart rates during normal conduction and consistent alterations of the HPS activity during abnormal conduction.
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
Authors: Alfons Meindl, Heide Hellebrand, Constanze Wiek, Verena Erven, Barbara Wappenschmidt, Dieter Niederacher, Marcel Freund, Peter Lichtner, Linda Hartmann, Heiner Schaal, Juliane Ramser, Ellen Honisch, Christian Kubisch, Hans E Wichmann, Karin Kast, Helmut Deißler, Christoph Engel, Bertram Müller-Myhsok, Kornelia Neveling, Marion Kiechle, Christopher G Mathew, Detlev Schindler, Rita K Schmutzler, Helmut Hanenberg
Journal: Nature Genetics (2010)
Systemic Sclerosis: Scleroderma
Authors: George E. Ehrlich
Journal: JAMA (1989)

Fourteen years ago, I had the pleasure of reviewing Prof Stefania Jablonska's monograph,<i>Scleroderma</i><i>and Pseudoscleroderma</i>, for this journal. The publication of the current volume in 1988 permits us to understand the major advances in diagnosis, understanding of the disease, and treatment that the interval provided. And yet, if we accept the five outcome measures of disease championed by Fries and carefully defined in our book<i>Prognosis</i>, namely, death, disease activity, disability, treatment, and costs (listed, for the convenience of having five D's, as drugs and dollars), there are grounds for optimism. While mortality figures after diagnosis may not be particularly favorable, the introduction of angiotensinconverting enzyme inhibitors and other contemporary treatments may well influence the equation favorably. Systemic sclerosis is not rare in specialized practices and university centers, which concentrate such cases. A recently concluded cooperative study in the United States contributed hundreds of cases, and more than 5000