tbuckley/cabot-search huggingface dataset:
Barbed Absorbable Suture Closure for Large Mohs Surgery Defect
Authors: John Strasswimmer, Ben Latimer, Hanna Speer
Journal: JAMA Dermatology (2013)

Report of a CaseAn 83-year-old man presented with a recurrent micronodular basal cell carcinoma located on the left lateral chest measuring 2.3 × 2.1 cm.His medical history was significant for coronary artery disease and the use combined clopidogrel bisulfate and aspirin antiplatelet therapy, which was maintained during surgery.The tumor was extirpated with 6 stages of Mohs micrographic surgery, producing a 10.5 × 8.9-cm defect to the deep subcutaneous tissue.The patient was adamant about returning to his recreational activities, including golf, as soon as possible.Wound management options were discussed with the patient, and the limitations of each were noted.
The Association of Socioeconomic Status with Outcomes in Cystic Fibrosis Patients in the United States
Authors: MICHAEL S. SCHECHTER, BRENT J. SHELTON, PETER A. MARGOLIS, STACEY C. FITZSIMMONS
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

There is considerable variability in the clinical course of disease in cystic fibrosis (CF). Although currently unidentified modifier genes might explain some of this heterogeneity, other factors are probably contributory. Socioeconomic status (SES) is an important predictor of health status in many chronic polygenic diseases, but its role in CF has not been systematically evaluated. We performed a historical cohort analysis of pediatric CF patients in the United States using National Cystic Fibrosis Foundation Patient Registry (NCFPR) data for 1986 to 1994, and used Medicaid status as a proxy for low SES. The adjusted risk of death was 3.65 times higher (95% confidence interval [CI]: 3.03 to 4.40) for Medicaid patients than for those not receiving Medicaid. The percent predicted FEV(1) of surviving Medicaid patients was less by 9.1% (95% CI: 6.9 to 11.2). Medicaid patients were 2.19 times more likely to be below the 5th percentile for weight (95% CI: 1.91 to 2.51) and 2.22 times more likely to be below the 5th percentile for height (95% CI: 1.95 to 2.52) than were non-Medicaid patients. Medicaid patients were 1.60 times more likely to require treatment for a pulmonary exacerbation (95% CI: 1.29 to 1.98). There was no difference in the number of outpatient clinic visits for Medicaid and non-Medicaid patients. We conclude that low SES is associated with significantly poorer outcomes in children with CF. Barriers in access to specialty health care do not seem to explain this difference. Further study is indicated to determine what adverse environmental factors might cluster in CF patients of low SES to cause worse outcomes.
Effects of peripheral vasoconstriction on the measurement of blood pressure in a finger
Authors: K. H WESSELING, J. J SETTELS, G. M A V. D. HOEVEN, J. A NIJBOER, M. W T BUTIJN, J. C DORLAS
Journal: Cardiovascular Research (1985)

Using noninvasive techniques only, the fall in mean pressure and the pulse amplification between brachial and finger arterial pressure were measured in six anaesthetised female subjects during surgery. Brachial pressure was measured every 2 min with an oscillometric technique. Finger pressure was measured continuously using an arterial volume clamp method. In addition changes in the degree of peripheral vasoconstriction were established on an adjacent finger with a photo reflection plethysmograph. On the average finger mean pressure is 10 mmHg below brachial pressure. The difference tends to decrease with increasing constriction. The change in the difference between full constriction and maximal dilatation is 8 mmHg. The average finger to brachial pulse amplitude ratio changes from 110% at maximal dilatation to 170% at full constriction. Finger systolic pressure overshoot is responsible for the pulse wave amplification. On the average it is + 7 mmHg and ranges between maximal dilatation and full constriction over 26 mmHg. The standard error deviation on the volume clamp method could be established at 5% for mean pressure, about equal to that of the oscillometric technique in the literature.
Ryanodine receptor-mediated arrhythmias and sudden cardiac death
Authors: Lynda M. Blayney, F. Anthony Lai
Journal: Pharmacology & Therapeutics (2009)

The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (SR) transmembrane protein that plays a central role in excitation-contraction coupling (ECC) in cardiomyocytes. Aberrant spontaneous, diastolic Ca2+ leak from the SR due to dysfunctional RyR2 contributes to the formation of delayed after-depolarisations, which are thought to underlie the fatal arrhythmia that occurs in both heart failure (HF) and in catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT is an inherited disorder associated with mutations in either the RyR2 or a SR luminal protein, calsequestrin. RyR2 shows normal function at rest in CPVT but the RyR2 dysfunction is unmasked by physical exercise or emotional stress, suggesting abnormal RyR2 activation as an underlying mechanism. Several potential mechanisms have been advanced to explain the dysfunctional RyR2 observed in HF and CPVT, including enhanced RyR2 phosphorylation status, altered RyR2 regulation at luminal/cytoplasmic sites and perturbed RyR2 intra/inter-molecular interactions. This review considers RyR2 dysfunction in the context of the structural and functional modulation of the channel, and potential therapeutic strategies to stabilise RyR2 function in cardiac pathology.
Inhibition of Ocular Neovascularization by Hedgehog Blockade
Authors: Enrico M. Surace, Kamaljit S. Balaggan, Alessandra Tessitore, Claudio Mussolino, Gabriella Cotugno, Ciro Bonetti, Aniello Vitale, Robin R. Ali, Alberto Auricchio
Journal: Molecular Therapy (2005)

Ocular neovascularization associated with proliferative diabetic retinopathy and age-related macular degeneration is the leading cause of severe visual loss in adults in developed countries. Physiological and pathological retinal angiogenesis may occur independently in postnatal life through the complex activation of pro- and antiangiogenic pathways. We report that the Sonic hedgehog (Shh) pathway is activated in the retina in animal models of retinal and choroidal neovascularization. We show that pharmacological inhibition of the Shh signaling pathway significantly reduces physiological retinal angiogenesis and inhibits pathological vascularization in both models. Under retinal hypoxic conditions, inhibition of the Shh pathway results in reduction of vascular endothelial growth factor (VEGF) level, along with that of Patched-1 (Ptch1), a canonical Shh target, thus placing Shh activation upstream of VEGF in experimental retinal neovascularization. Our data demonstrate the requirement of the Shh pathway for retinal angiogenesis and its inhibition as a potential therapeutic strategy targeting ocular neovascular disease.
Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene
Authors: Angelo B. Cefalù, Pier L. Calvo, Davide Noto, Maurizio Baldi, Vincenza Valenti, Pietro Lerro, Fabio Tramuto, Antonella Lezo, Isabella Morra, Giovanna Cenacchi, Cristiana Barbera, Maurizio R. Averna
Journal: Metabolism (2009)
Perception of Heart Rate and Blood Pressure: The Role of Alexithymia and Anxiety
Authors: G.W.B. Näring, C.P.F. van der Staak
Journal: Psychotherapy and Psychosomatics (1995)

While the ability to estimate heart rate in a laboratory setting appears to be related to anxiety and alexithymia, it is still unclear how the ability to estimate blood pressure is related to these psychological measures. The perception of heart rate and blood pressure in 24 normotensive subjects with varying degrees of alexithymia and anxiety was examined. Results indicate that the estimation of heart rate is related to psychological characteristics, while the estimation of blood pressure is not. More anxious subjects perceived heart rate more accurately than less anxious subjects. Furthermore, high alexithymic subjects perceived heart rate less accurately than low alexithymic subjects. The accuracy of estimation of blood pressure was, however, not related to alexithymia or anxiety. These findings provide further evidence that blood pressure estimates in a laboratory setting are mainly based upon situational cues.
Extracellular and intracellular actions of adenosine and related compounds in the reperfused rat intestine.
Authors: P M Kaminski, K G Proctor
Journal: Circulation Research (1992)

By using pharmacological tools, the biological actions of adenosine (ADO) were manipulated in rat intestine that had been rendered ischemic for 5 or 15 minutes and reperfused for 1 or 24 hours. With 100 microM ADO topically administered for 30 minutes after ischemia and then washed out, intestinal arteriolar blood flow (BF) and tissue ATP were restored to preocclusion levels, and histological damage was minimal after 1 hour of reperfusion. For comparison, with vehicle treatment after ischemia, BF was reduced by 50%, tissue ATP was reduced by 50%, myeloperoxidase levels in the intestine and lung were increased at least twofold, and mucosal villi were shortened and thickened after 1 hour of reperfusion. Furthermore, with vehicle treatment, both baseline BF and reactivity to endothelium-dependent (acetylcholine) and endothelium-independent (2-chloroadenosine) vasodilators were significantly depressed after 24 hours of reperfusion. In contrast, with ADO, baseline BF remained near normal, and vascular reactivity to 2-chloroadenosine and acetylcholine was preserved after 24 hours. The salutary effect of ADO on BF was reduced by simultaneous application of the antagonist 8-phenyltheophylline or the cellular uptake inhibitor dipyridamole. The nonmetabolized agonist 2-chloroadenosine, the purine precursor aminoimidazole carboxamide riboside, or dipyridamole alone all had favorable effects relative to the vehicle, but all were less potent than ADO. The conclusions are as follows: 1) Endogenous ADO modulates the inflammatory response evoked by intestinal reperfusion because aminoimidazole carboxamide riboside or dipyridamole, which increases its availability, generally had favorable effects, whereas 8-phenyltheophylline tended to have opposite effects. 2) Exogenous ADO arrests most of the inflammatory changes associated with reperfusion by mechanisms that include both extracellular (e.g., receptor-mediated vasodilation and granulocyte inhibition) and intracellular (e.g., restoration of ATP) actions. 3) The effectiveness of ADO-related compounds even when administered after ischemia attests to the practicality of salvaging ischemic bowel, at least in some conditions.
Future of child guidance clinics.
Authors: K A Graf
Journal: BMJ (1972)

dialysis and non-dialysis group were com- parable for age and sex and whether the apparent differences in small numbers of patients was statistically significant.We studied the immediate effect of dialysis and found no significant difference in the peak acid output measured in the same 14 patients before and after dialysis,2 but on reviewing our data we find that the basal acid output was significantly reduced after dialysis (P<O.05).The peak acid output measures the parietal cell mass and perhaps its sensitivity to pentagastrin, but the changes in basal acid output, though less reproduceable, may reflect the changes in urea and electrolytes produced by dialysis.-Iam, etc.,
Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma
Authors: Geoffrey R. Hill, Stuart D. Olver, Rachel D. Kuns, Antiopi Varelias, Neil C. Raffelt, Alistair L. Don, Kate A. Markey, Yana A. Wilson, Mark J. Smyth, Yoichiro Iwakura, Joel Tocker, Andrew D. Clouston, Kelli P. A. MacDonald
Journal: Blood (2010)
Crossed Fused Renal Ectopia with Metastatic Renal Cell Carcinoma
Authors: Herrick J. Siegel, Mark A. Casillas
Journal: Clinical Nuclear Medicine (2004)

The patient is an 83-year-old man with a 4-month history of right arm pain. He had no previous history of cancer. Radiographs showed a minimal pathologic fracture of the proximal right humerus with new callus formation at the fracture site. A bone scan was done but did not demonstrate other areas of involvement. However, it was noted that the patient did not appear to have a left kidney, and there were 2 areas of increased uptake in the region of the right kidney. A CT scan of the abdomen and pelvis was done and showed a crossed fused ectopic kidney with a 3 × 4 cm mass on its inferior pole. A biopsy of the right humerus lesion confirmed that it was metastatic renal cell carcinoma, and the patient underwent a nephrectomy of the involved kidney.
Determinants of childhood mortality
Authors: A. Hodge, E. Jimenez-Soto
Journal: BMJ (2013)

Millennium development goal 4 calls for a reduction in the mortality rate in under 5s by two thirds between 1990 and 2015. Despite an impressive 47% drop in the global rate since 1990, the rate of decline is too slow to meet that target, particularly in sub-Saharan Africa and southern Asia.1 It is therefore important to know why some countries are making poor progress. Despite previous studies, there is no strong evidence base defining the determinants of cross country child mortality, which would be an important step towards developing effective policies to tackle high death rates. In a welcome contribution, the linked study by Hanf and colleagues (doi:10.1136/bmj.f6427) revisits the associations between global factorsmsuch as socioeconomic conditions, health variables, and political contextsmand national rates of death in under 5s...
THE MAMMALIAN CELL-VIRUS RELATIONSHIP
Authors: Leroy C. McLaren, John J. Holland, Jerome T. Syverton
Journal: The Journal of Experimental Medicine (1960)

All primary cell cultures tested from numerous human and rhesus monkey tissues were susceptible to Coxsackie A9 virus infection and were found to contain a specific A9 virus receptor. Ability of these cells to adsorb actively virus correlated with the presence of this receptor. Attachment of A9 virus to cell receptor was specifically enhanced by calcium and magnesium ions. Human cells established in continuous culture from pretested susceptible cultures were found to have lost A9 virus susceptibility and A9 receptors but not receptors for adsorption of type 1 poliovirus or B1, B3, B5 Coxsackie viruses. These cultures were able also to produce infectious A9 virus after exposure to viral RNA. Coxsackie A9 virus as well as type 1 poliovirus, inactivated following reaction with debris prepared from susceptible cells, could be recovered fully in infectious form by treatment of the inactive systems at low pH. Recovery of infectious A9 virus was also possible with a chelating compound. Coxsackie A9 virus could also be dissociated by means of low pH after adsorption onto susceptible cells for 2 minutes at 1°C., but not after 1 hour incubation at 37°C., indicating that viral host cell activity may be required in order for irreversible enterovirus attachment to take place.
Drugs Five Years Later
Authors: RICHARD A. BRODKIN
Journal: Annals of Internal Medicine (1978)

Androgens are effective therapeutic agents in postmenopausal women with metastatic breast cancer. Early studies with testosterone propionate showed objective regression rates of slightly more than 20%. Subsequent work with synthetic androgens has failed to show a significant reduction in toxicity or an increase in therapeutic efficacy over testosterone propionate. Calusterone (7β,17α-dimethyltestosterone), in early clinical trials, showed both of these qualities and was believed by some to be the "ideal androgen." As with many new drugs, subsequent work failed to confirm these early findings, and most of the later data gathered on calusterone are inconsistent. We conclude from our knowledge at present that calusterone offers no real advantages or disadvantages over other androgens in the treatment of breast cancer.
A new look at evidence about reduced cost of medical utilization following mental health treatment
Authors: E Mumford, H J Schlesinger, G V Glass, C Patrick, T Cuerdon
Journal: American Journal of Psychiatry (1984)

Meta-analysis of 58 controlled studies and analysis of the claims files for the Blue Cross and Blue Shield Federal Employees Plan for 1974-1978 provide mutually supporting evidence of the cost-offset effects of outpatient mental health treatment. These two complementary resources provide a powerful tool for investigating the nature of associations between mental health services and subsequent reductions in the use of other medical services. The authors found that the reductions in use of medical services are associated with inpatient rather than with outpatient utilization and tend to be larger for persons over 55 years of age.
The Risk of AIDS After Hepatitis Vaccination
Authors: G. Papaevangelou
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The purification and inactivation process of the Merck, Sharp &amp; Dohme hepatitis B vaccine prepared from plasma is known to inactivate representatives of all known groups of animal viruses. However, fears that an acquired immunodeficiency syndrome (AIDS) agent contaminates the vaccine have deterred its use. In a recent issue of<i>JAMA</i>, Sacks et al<sup>1</sup>showed that for persons at increased risk of hepatitis B, reluctance to be vaccinated because of this fear is groundless. Their best estimate of the vaccine-induced AIDS rate was zero, since among 500,000 vaccine recipients no case of AIDS has occurred in individuals who do not have other risk factors, and follow-up studies have shown that the frequency of AIDS in homosexual men who received the vaccine is similar to that in an unvaccinated group of homosexual men.<sup>2</sup> Now that lymphadenopathy virus/ human T-cell leukemia virus-III (LAV/HTLV-III) has been identified as
ECTOPIC PREGNANCY OF AN ANOMALOUS FALLOPIAN TUBE
Authors: Joseph W. Steckbauer
Journal: JAMA (1926)

This case is reported to put on record an unusual ectopic pregnancy. The symptoms in the case also suggested a pathologic condition on the right side, whereas the ectopic pregnancy was found on the left side. <h3>REPORT OF CASE</h3> A fairly well developed girl, aged 19, married, entered the St. Louis City Hospital, complaining of colicky pains in the right lower quadrant. The pain at first was general; it came on suddenly and gradually grew worse. Vomiting began before the pain. Although, at the time of admission, the patient denied fainting, she admitted after the operation that she fainted three or four times between three and seven hours after the first attack of pain. She began menstruating at the age of 14, and had had no dysmenorrhea. The menstrual periods were always irregular, varying from twenty-one to thirty days. The last period was twenty-eight days before she was taken sick.
Primary prevention of neural tube defects with folic acid.
Authors: C J Schorah, R W Smithells
Journal: BMJ (1993)

Diabetic care in general pracdce EDITOR,-The findings of Pringle and colleagues that access to a dietitian improves metabolic control' confirms others' work.2Presumably this is why doctors want dietitians to advise people with diabetes34 and why the British Diabetic Association recommends that diabetics should see a dietitian at diagnosis and yearly thereafter."It is illogical for Pringle and colleagues to conclude that it would be more appropriate for dietitians to train practice nurses than to see patients.How much and what sort of training would be needed to achieve similarly good results?Can nurses be released for training?Do dietitians have the time to train?What happens to all the patients who are not being advised because the dietitians and nurses are involved in training courses?What training in teaching do dietitians need to train others, and do they have these skills?None of these issues were covered in the study.Nor was the cost of providing services.A senior 1 dietitian's salary is comparable to that of an F grade nurse and slightly less than that of a nurse on grade G.People with diabetes should get dietary advice from a dietitian.This gives a better metabolic outcome and represents excellent value for money.It adds up to the best service to patients, which is what it's all about.
Mapping of a familial essential tremor gene, FET1, to chromosome 3q13
Authors: Gulcher, Jónsson P, Kong A, Kristjánsson K, Frigge Ml, Kárason A, Einarsdóttir Ie, Stefánsson H, Einarsdóttir As, Sigurthoardóttir S, Baldursson S, Björnsdóttir S, Hrafnkelsdóttir Sm, Jakobsson F, Benedickz J, Stefánsson K
Journal: Nature Genetics (1997)
Abstract 4420: Serum regulates reovirus-mediated cytopathy in K-Ras activated colorectal cancer and intestinal epithelial cell lines
Authors: Radhashree Maitra, Titto Augustine, Raviraja N. Seetharam, Matthew C. Coffey, Lidija Klampfer, John John.Mariadason, Sanjay Goel
Journal: Cancer Research (2012)

Abstract Background: The oncolytic potency of replication competent REOvirus has been demonstrated in various cancers. The activity is most pronounced in Kras mutant cancer cells, which account for 30-40 % of all cancers. Herein we simultaneously utilized isogenic human derived colorectal cancer cell lines that differ only by the presence of mutant Kras and normal rat intestinal epithelial cells with inducible Kras to evaluate whether the presence of oncogenic Kras alters the sensitivity of colon cancer cells to reovirus. Methods: Reovirus was obtained from Oncolytics Biotech Inc. Rat IEC's harboring IPTG inducible mutant Ras oncogene (IEC-iKras) were treated with reovirus ± IPTG. The infectivity was maintained at a multiplicity of infection (MOI) of 2. MTT assay was performed at 72 hours to determine cell vability (CV). Similar experiments were also performed with HCT116 (Kras mut) and its isogenic derivative Hke3 [(Kras wild type (WT)]. Cells were cultured and treated in both serum rich (SR) and serum free (SF) media to determine the effect of growth factors on sensitivity to reovirus. Alterations in gene expression were determined by real time PCR and protein expression by western blot. Results: The activity of reovirus was observed in all cell lines studied. Reduction in CV was greater in Kras mutant HCT116 compared to WT Hke3 cells. Consistently, induction of Kras in IEC cells increased the potency of reovirus. Furthermore, this effect was more prominent in cells cultured in SF suggesting that growth factors in the serum may attenuate the effect of mutant Kras on reovirus sensitivity. Expression of the cell cycle regulator, p21 was preferentially increased upon reovirus infection in Kras mutant compared to WT cells, and in cells cultured in SF compared to SR conditions. Conclusion: Oncogenic Kras mutations increase the sensitivity of colon cancer cells to Reovirus. Clinical trials are underway testing reovirus in patients with Kras mutant metastatic colorectal cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4420. doi:1538-7445.AM2012-4420