tbuckley/cabot-search huggingface dataset:
Comparison of in-111 Granulocytes and Tc-99m Albumin Colloid for Bone Marrow Scintigraphy by the Use of Quantitative SPECT Imaging
Authors: BERTH AXELSSON, B O KALIN, SUSANNA VON KRUSENSTIERNA, HANS JACOBSSON
Journal: Clinical Nuclear Medicine (1990)

A comparison of in-111 oxinate labeled autologous granulocytes and Tc-99m albumin colloid for bone marrow scintigraphy is reported. The aim of this report was to determine if the intense uptake in the liver and spleen with nano-sized colloids, which hampers the evaluation of the skeletal parts surrounding the liver, is reduced by the use of radiolabeled granulocytes. This study is based on a retrospective analysis of 19 abdominal tomographic examinations with ln-111 granulocytes performed to detect septic foci. After correction for attenuation and scattering of photons was performed, the uptake in the bone marrow of the lumbar spine was seen to be related to the liver, spleen, and tissue background activity. The results in this study were compared with corresponding data from 20 normal liver/spleen tomographic examinations performed with Tc-99m nanocolloid, which is routinely used for bone marrow scintigraphy. The bone marrow/liver activity ratio for granulocytes varied, but it exceeded the corresponding mean ratio for colloid in all examinations. The mean values for granulocyte uptake 3 and 20 hours after injection was, respectively, about 6 and almost 10 times higher than were those for colloid. The activity ratios between bone marrow and spleen as well as between bone marrow and tissue background was not improved and or may even have been reduced by the use of granulocytes. It is suggested that granulocytes labeled in vitro by Tc-99m hexamethylpropylene amineoxime (HMPAO) or in vivo by monoclonal antigranulocyte anti bodies may provide techniques for improved bone marrow imaging.
The Electrocardiogram in Infarction of the Lateral Wall of the Left Ventricle
Authors: WILLIAM J. DUNN, JESSE E. EDWARDS, RAYMOND D. PRUITT
Journal: Circulation (1956)

This reappraisal of the electrocardiographic manifestations of infarction of the lateral wall of the left ventricle is based on data acquired by simple and conventional technics. Categories of cases have been determined by the age of the infarct and the distribution of the lesion with respect to the circumference of the left ventricular wall and its epicardial and endocardial boundaries. Significant data have been presented in the form of illustrative diagrams and reproductions. The results do not establish a simple pattern common to all cases of infarction of the lateral wall; they do illustrate the varied yet limited electrocardiographic consequences of such lesions.
Phase I Pharmacokinetic Study of S-1 Granule and Nedaplatin for Patients with Recurrent/Metastatic Head and Neck Cancer
Authors: K. Tanaka, H. Hayashi, I. Okamoto, S. Ueda, K. Okamoto, H. Kawakami, S. Nishina, M. Takeda, K. Doi, K. Nakagawa
Journal: Annals of Oncology (2013)
Transferrin‐Mediated Rapid Targeting, Isolation, and Detection of Circulating Tumor Cells by Multifunctional Magneto‐Dendritic Nanosystem
Authors: Shashwat S. Banerjee, Archana Jalota‐Badhwar, Sneha D. Satavalekar, Sujit G. Bhansali, Naval D. Aher, Russel R. Mascarenhas, Debjani Paul, Somesh Sharma, Jayant J. Khandare
Journal: Advanced Healthcare Materials (2012)

A multicomponent magneto-dendritic nanosystem (MDNS) is designed for rapid tumor cell targeting, isolation, and high-resolution imaging by a facile bioconjugation approach. The highly efficient and rapid-acting MDNS provides a convenient platform for simultaneous isolation and high-resolution imaging of tumor cells, potentially leading towards an early diagnosis of cancer. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Psychological Adjustment of Children With Recently Diagnosed Diabetes Mellitus
Authors: A M Jacobson, S T Hauser, D Wertlieb, J I Wolfsdorf, J Orleans, M Vieyra
Journal: Diabetes Care (1986)

Children with recent onset of insulin-dependent diabetes mellitus (IDDM) were compared with a sample of children with a recent acute medical problem. No differences were found in terms of self-esteem, locus of control, behavioral symptoms, or social functioning. A separate assessment of adjustment to diabetes was strongly correlated with each of these general personality, behavioral symptom, and social functioning measures. Sociodemographic factors such as age, gender, and social class did not predict the level of adjustment to diabetes. This study suggests that onset of diabetes does not necessarily lead to major disruptions of psychological adaptation. It also affirms the view that early adjustment to diabetes is embedded in a context of overall personality development and adaptation.
Abstract A03: Effectiveness of melatonin on the epithelial mesenchymal transition after induction with transforming growth factor beta (TGF-β)
Authors: Naiane do Nascimento Gonçalves, Lívia Carvalho Ferreira, Juliana Ramos Lopes, Larissa Bazela Maschio, Marina Gobbe Moschetta, Gabriela Bottaro Gelaleti, Gustavo Rodrigues Martins, Debora Aparecida Pires de Campos Zuccari
Journal: Cancer Research (2015)

Abstract Background: The mammary tumors are the most frequent in women in Brazil and worldwide. The high mortality rate in breast cancer is mainly due to invasiveness and metastatic. The metastatic process involves a mechanism called epithelial-mesenchymal transition (EMT). The EMT mechanism can be induced by growth factors such as transforming growth factor beta (TGF-β), which alters the epithelial phenotype (E-cadherin) to a mesenchymal phenotype (n-caderina/vimentina). Studies have shown significant importance of the epithelial mesenchymal transition in breast cancer, which makes the study of new therapeutic agents that act in the process, very important. Melatonin, a hormone naturally secreted by the pineal gland, has shown oncostatic properties. For these reasons, the aim of this study was to evaluate the anti-metastatic potential of melatonin by the epithelial mesenchymal transition induced by TGF-β in breast cancer cell line. Methods: The breast cancer cell line MCF-7 was cultured at 37 ° C and 5% CO2 in DMEM High Glucose culture medium. Once established, the best concentration of TGF-β (0.5 ng / mL) to induce epithelial mesenchymal transition the cells were divided into four groups (Group I - Control, Group II - TGF-β, Group III - Melatonin and Group IV - TGF- β + Melatonin) to evaluate the protein expression of E-cadherin, N-cadherin and vimentin by immunocytochemistry. Quantitation of immunoreactivity was performed by densitometry (ImageJ software). The results were compared by ANOVA followed by Bonferroni. Results: The results showed that there were statistically significant increased protein e-cadherin in cells treated with melatonin (P &amp;lt; 0.05) when compared to cells treated with TGF-β. Furthermore, immunostaining of proteins N-cadherin and vimentin was lower in cells treated with TGF-B + melatonin (P &amp;lt; 0.05) compared to cells treated only with TGF-β. Conclusion: Melatonin interfered in the expression of proteins related to epithelial mesenchymal transition after induction with TGF-B which may suggested a possible anti-metastatic role of this hormone. Citation Format: Naiane do Nascimento Gonçalves, Lívia Carvalho Ferreira, Juliana Ramos Lopes, Larissa Bazela Maschio, Marina Gobbe Moschetta, Gabriela Bottaro Gelaleti, Gustavo Rodrigues Martins, Debora Aparecida Pires de Campos Zuccari. Effectiveness of melatonin on the epithelial mesenchymal transition after induction with transforming growth factor beta (TGF-β). [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr A03. doi:10.1158/1538-7445.CHTME14-A03
Of Beverages, Cigarettes, and Cardiac Arrhythmias
Authors: Timothy J. Regan
Journal: New England Journal of Medicine (1979)

An association between alcohol use and cardiac arrhythmias, particularly atrial fibrillation, has long been suspected, largely on the basis of case reports. The sporadic nature of such reports has suggested that special circumstances, such as exceptional fatigue, are essential to the phenomenon. This issue of the Journal contains a particularly instructive report of a patient who had no evidence of heart disease other than a history of palpitations and ventricular tachycardia confirmed by electrocardiography. A long-term alcohol abuser, the patient experienced arrhythmia only while drinking. In this patient, who had a normal heart size and normal coronary arteriograms, the pathogenetic . . .
The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML
Authors: V Novotny-Diermayr, S Hart, K C Goh, A Cheong, L-C Ong, H Hentze, M K Pasha, R Jayaraman, K Ethirajulu, J M Wood
Journal: Blood Cancer Journal (2012)

Acute myeloid leukemia (AML) is currently treated with aggressive chemotherapy that is not well tolerated in many elderly patients, hence the unmet medical need for effective therapies with less toxicity and better tolerability. Inhibitors of FMS-like tyrosine kinase 3 (FLT3), JAK2 and histone deacetylase inhibitors (HDACi) have been tested in clinical studies, but showed only moderate single-agent activity. High efficacy of the HDACi pracinostat treating AML and synergy with the JAK2/FLT3 inhibitor pacritinib is demonstrated. Both compounds inhibit JAK-signal transducer and activator of transcription (STAT) signaling in AML cells with JAK2(V617F) mutations, but also diminish FLT3 signaling, particularly in FLT3-ITD (internal tandem duplication) cell lines. In vitro, this combination led to decreased cell proliferation and increased apoptosis. The synergy translated in vivo in two different AML models, the SET-2 megakaryoblastic AML mouse model carrying a JAK2(V617F) mutation, and the MOLM-13 model of FLT3-ITD-driven AML. Pracinostat and pacritinib in combination showed synergy on tumor growth, reduction of metastases and synergistically decreased JAK2 or FLT signaling, depending on the cellular context. In addition, several plasma cytokines/growth factors/chemokines triggered by the tumor growth were normalized, providing a rationale for combination therapy with an HDACi and a JAK2/FLT3 inhibitor for the treatment of AML patients, particularly those with FLT3 or JAK2 mutations.
A Cross-over Study Comparing the Kinetics of Tc-99m-labeled Diisopropyl and P-Butyl IDA Analogs in Patients
Authors: MANUEL HERNANDEZ, LEONARD ROSENTHALL
Journal: Clinical Nuclear Medicine (1980)

Tc-99m-diisopropyl-IDA (DISIDA) and Tc-99m-p-butyl-IDA (BIDA) were compared in each of 33 patients who had serum bilirubins ranging from normal to 23.5 mg/dl. DISIDA exhibited quantitatively a higher liver uptake and faster rate of washout at all levels of bilirubinemia. There was a tendency for BIDA to have a slower blood clearance, particularly in hyperbilirubinemias exceeding 5 mg/dl. On visual comparison of the images, BIDA failed to identify the gallbladder in three icteric patients and dilated biliary tracts in two others.
Pernicious anaemia and intestinal malabsorption
Authors: I. M. Murray-Lyon, N. D. C. Finlayson
Journal: BMJ (1967)

TI we pulse meter recordings after operation show a return to normal of the amplitude and form of the pulse wave both before and after exercise (Figs. 3 and4).Postoperative arterio- graphy shows how completely the arterial lumen returned to normal.
Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia
Authors: Changqing Wang, Laurent R. Chiarelli, Paola Bianchi, Donald J. Abraham, Alessandro Galizzi, Andrea Mattevi, Alberto Zanella, Giovanna Valentini
Journal: Blood (2001)
Gene Cloning by Press Conference
Authors: Spyros Andreopoulos
Journal: New England Journal of Medicine (1980)

For years many scientists have maintained that science journalists are frequently inaccurate, that they oversimplify, and that in their rush for deadlines and headlines they fail to wait for completion of the orderly processes of scientific review and publication.In recent months, however, we have begun to witness a reversal unheard of in the annals of scientific communication: the phenomenon of scientists publishing research data by press conference.It is not entirely clear what is causing this departure from the established norms; however, there is evidence that competition and the increasing involvement of academic scientists in the field of commercial . . .
Buildings operations and ETS exposure.
Authors: J D Spengler
Journal: Environmental Health Perspectives (1999)

Mechanical systems are used in buildings to provide conditioned air, dissipate thermal loads, dilute contaminants, and maintain pressure differences. The characteristics of these systems and their operations h implications for the exposures of workers to environmental tobacco smoke (ETS) and for the control of these exposures. This review describes the general features of building ventilation systems and the efficacy of ventilation for controlling contaminant concentrations. Ventilation can reduce the concentration of ETS through dilution, but central heating, ventilating, and air conditioning (HVAC) can also move air throughout a building that has been contaminated by ETS. An understanding of HVAC systems is needed to develop models for exposures of workers to ETS.
DIAGNOSTIC ASPECTS OF A STUDY OF INTRACELLULAR PHOSPHORYLATIONS IN SCHIZOPHRENIA
Authors: IVAN BOSZORMENYI-NAGY, FRANCIS J. GERTY
Journal: American Journal of Psychiatry (1955)

1. This test affords a means for study of intracellular biochemical changes. 2. Proceeding from the fact that it has given quite uniform results in a fairly large healthy control group of persons and that different results are obtained in the cases of some clinically psychotic patients, we may classify the test results of the first group as normal and of the second group as pathological. 3. The test gives normal response in the cases of most of our patients diagnosed clinically as suffering from psychiatric conditions other than schizophrenia as well as in diabetics and hyperthyroid cases. 4. Pathological test results are obtained chiefly within the schizophrenic range of diagnoses but some of the most clinically characteristic schizophrenics give normal results with this test. 5. Present indications are that there is some factor present within the group of schizophrenic spectrum cases which is common to many of these cases but that the central group of well confirmed, long-term cases of schizophrenia is itself not positively distinguishable by this means. 6. At the present state of the investigation the cases showing "normal type" enzymatic response can be tentatively characterized by the lack of the symptomatology of an acute psychotic attack of a sudden onset as it is typical in cases described as simple schizophrenia.
Which patients with suspected appendicitis should undergo laparoscopy?
Authors: S Paterson-Brown, J N Thompson, J R T Eckersley, G A Ponting, H A F Dudley
Journal: BMJ (1988)

CommentOur patient showed a remarkable initial response to high dose intravenous gammaglobulin.The effect on his arthritis was transient, but most of the systemic symptoms were appreciably reduced or absent during the first six months of treatment.A relapse occurred four months after gammaglobulin was stopped, but renewed administration induced the same beneficial effects as before.The mechanism of action is uncertain.Reactions between idiotypes and anti-idiotypes or blockade of the Fc receptors of the macrophages by the gammaglobulin could explain the increased circulating concentration of immune complexes.4We cannot explain the temporarily increased IgM rheumatoid factor concentration.High dose intravenous gammaglobulin may be useful in treating severe chronic systemic juvenile arthritis.We recommend that a double blind, randomised prospective trial of its effects should be performed.1 Imbach P, Barandin S, d'Apurizo V, et al.High-dose intravenous gammaglobulin for idiopathic thrombocytic purpura in childhood.
Beneficial hemodynamic effects of bosentan, a mixed ETA and ETB receptor antagonist, in portal hypertensive rats
Authors: Philippe Sogni, Richard Moreau, Alexandra Gomola, Adrian Gadano, Stephane Cailmail, Yvon Calmus, Martine Clozel, Didier Lebrec
Journal: Hepatology (1998)

In patients with cirrhosis, the plasma level of endothelin, a potent vasoconstrictor peptide, is elevated, and endothelin plays a role in increased intrahepatic vascular resistance. Thus, the aim of this study was to evaluate the hemodynamic effects of bosentan, a mixed ET(A) and ET(B) endothelin receptor antagonist in three models of portal hypertension. In all groups of rats, endothelin (2 microg/kg intravenously) administration significantly increased intrahepatic vascular resistance. In rats with secondary biliary cirrhosis, bosentan (30 mg/kg) significantly reduced portal pressure from 14.6 +/- 1.2 to 12.1 +/- 0.6 mm Hg, while portal blood flow and cardiac output increased by 45% and 57%, respectively. Thus, hepatocollateral vascular resistance decreased significantly from 177 +/- 19 to 101 +/- 9 dyn x s x cm(-5) x 10(-3). Similar results were observed in rats with CCl4-induced cirrhosis. In isolated perfused cirrhotic rat livers, bosentan (1 to 100 micromol/L) had no significant effect on hepatic vascular resistance. In portal vein-stenosed rats, bosentan administration significantly decreased portal pressure from 13.1 +/- 0.6 to 11.4 +/- 0.5 mm Hg by reducing portosystemic vascular resistance, because bosentan had no effect on vascular resistance of normal rat liver. In conclusion, bosentan administration decreased portal pressure in vivo by reducing hepatocollateral vascular resistance in rats with cirrhosis. Thus, mixed endothelin receptor antagonists might be a new approach in the pharmacological treatment of portal hypertension.
Genetic susceptibility to primary biliary cirrhosis (PBC): analysis of chemokine receptor 5 (CCR5) delta32 deletion
Authors: A.M. Baragiotta, A. Floreani, D. Jones, C. Venturi, K. Agarwal, O.F.W. James, P.T.D. Donaldson, M.F. Bassendine
Journal: Journal of Hepatology (2001)
Mechanism of biliary lipid secretion in the rat: A role for bile acid-independent bile flow?
Authors: Henkjan J. Verkade, Henk Wolters, Albert Gerding, Rick Havinga, Vaclav Fidler, Roel J. Vonk, Folkert Kuipers
Journal: Hepatology (1993)

Bile acid-induced lipid secretion was compared in unanesthetized normal control and Groningen Yellow Wistar rats during variations in endogenous bile acid output. Groningen Yellow rats express a genetic defect in the biliary secretion of various organic anions. During a 5-hr period after interruption of the enterohepatic circulation, bile acid secretion decreased from 36.4 +/- 1.8 to 1.9 +/- 0.3 mumol per 30 min in normal control rats and from 37.1 +/- 2.8 to 1.8 +/- 0.2 mumol per 30 min in Groningen Yellow rats, respectively (mean +/- S.E.M., n = 5). The relationship between bile acid secretion and bile flow showed similar slopes (normal control, 8.74 +/- 0.44 microliter/mumol and Groningen Yellow rats, 7.71 +/- 0.42 microliter/mumol) but different y-intercepts (normal control, 243 +/- 8 and Groningen Yellow, 127 +/- 4 microliters per 30 min; p < 0.001), corresponding to a 47% reduction of the bile acid-independent fraction of bile flow in Groningen Yellow rats. During the course of the experiment, the ratio of lipids (phospholipids plus cholesterol) to bile acids increased in both strains more than threefold but was permanently higher in Groningen Yellow than in normal control rats (p = 0.035), implying that Groningen Yellow rats continuously secreted more lipid per bile acid. No differences in bile acid pool composition or in bile canalicular membrane composition and fluidity between the two strains were detected. The results indicate that apart from previously demonstrated factors (bile acid concentration, bile acid composition and hydrophilic organic anion concentration in bile), another parameter affects the efficacy of bile acids to induce biliary lipid secretion.(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract 1547: Identification of somatic mutations and copy number alterations in metastatic high-grade ovarian cancer
Authors: Jung-Yun Lee, Jung-Ki Yoon, Duhee Bang, Yong-Sang Song
Journal: Cancer Research (2014)

Abstract Background: The extent to which metastatic tumors further evolve by accumulating additional mutations is unclear and has yet to be systematically addressed using next-generation sequencing in high-grade serous ovarian cancer. Methods: During cytoreductive surgery prior to chemotherapy, 11 spatially separated tumor samples from primary tumor and associated metastatic sites with 2 normal samples were obtained. Whole exome sequencing and copy number analysis were performed and multiplex PCR followed by ultra-deep resequencing was used for validation. Especially, omental samples were sequenced with high depth of coverage (∼200x).Phylogenetic tree was built to explore the evolutionary relationship between samples. Results: Only 6% of all somatic mutations were present in every sample of a given case with TP53 gene as the only known mutant gene consistently present in all samples. Two non-spatial clusters of primary samples (cluster 1 and 2), and a cluster of metastatic samples (cluster M) were identified. The patterns of mutations indicate that cluster M was originated from cluster 1, and that cluster 2 was diverged from a portion of right fimbriae in cluster 1 at the early phase of tumorigenesis. No significant metastatic sample-specific mutations or copy number changes were detected. Conclusion: Our results showed that high level of intratumor heterogeneity was evident in a high-grade serous ovarian cancer. Moreover, we showed that transcoelomic metastasis arises with little accumulation of somatic mutations or copy number alterations. Citation Format: Jung-Yun Lee, Jung-Ki Yoon, Duhee Bang, Yong-Sang Song. Identification of somatic mutations and copy number alterations in metastatic high-grade ovarian cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1547. doi:10.1158/1538-7445.AM2014-1547