tbuckley/cabot-search huggingface dataset:
Da Costa Syndrome Revisited
Authors: Samuel Vaisrub
Journal: JAMA (1975)

The syndrome, referred to in 1864 by Hartshorne<sup>1</sup>as "cardiac muscular exhaustion" and in 1871 by Da Costa<sup>2</sup>as "irritable heart syndrome," has undergone so many name changes that it is almost possible to "date" a physician by the name he selects. To an old-timer it may still be "Da Costa syndrome"; to a later graduate it may be "cardiac neurosis," "disordered action of the heart," "soldier's heart," "effort syndrome," or "neurocirculatory asthenia"; to a new arrival it can be Holmgren's<sup>3</sup>"vasoregulatory asthenia," Gorlin's<sup>4</sup>"hyperkinetic heart syndrome," or Frohlich's<sup>5</sup>"hyperdynamic β-adrenergic circulatory state." One wonders whether the doctor's choice of the appropriate label can serve as his screening test for recertification. Whatever its label, the symptom-complex characterized by palpitation, dyspnea, precordial pain, fatigue, exaggerated emotional responses with increased cardiac awareness, and occasionally, systolic hypertension, often presents a diagnostic and therapeutic dilemma, as well as a
Myocardial Extracellular Volume Expansion and the Risk of Recurrent Atrial Fibrillation After Pulmonary Vein Isolation
Authors: Tomas G. Neilan, Francois-Pierre Mongeon, Ravi V. Shah, Otavio Coelho-Filho, Siddique A. Abbasi, John A. Dodson, Ciaran J. McMullan, Bobak Heydari, Gregory F. Michaud, Roy M. John, Ron Blankstein, Michael Jerosch-Herold, Raymond Y. Kwong
Journal: JACC. Cardiovascular imaging (2013)
Paracoccidioidomycosis in patients with human immunodeficiency virus: review of 12 cases observed in an endemic region in Brazil
Authors: Anamaria Mello Miranda Paniago, Ana Carolina Carli de Freitas, Eliana Setti Albuquerque Aguiar, José Ivan Albuquerque Aguiar, Rivaldo Venâncio da Cunha, Ana Rita Coimbra Motta Castro, Bodo Wanke
Journal: Journal of Infection (2005)
Inhaled Plastic Cap
Authors: J. Sakula
Journal: BMJ (1966)

<h3>Introduction</h3> Self-directed and interpersonal violence among people with severe mental illness has become a health priority. Though non-pharmacological interventions have been investigated, to our knowledge, no summary of all systematic reviews on this topic has been reported. We will conduct a rapid overview of reviews to synthesise evidence available by identifying systematic reviews on non-pharmacological interventions for self-directed or interpersonal violence in people with severe mental illness. <h3>Methods and analysis</h3> This is a protocol for a rapid overview of reviews. The overview will include any systematic reviews (with or without meta-analyses) of randomised controlled trials (RCTs) or cluster RCTs that examine the effect of non-pharmacological interventions on self-directed or interpersonal violence in people with severe mental illness. This protocol applies the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Protocols, the criteria for conducting overviews of reviews in the Cochrane Handbook of Systematic Reviews of Interventions and the criteria for the Cochrane Rapid Reviews. To identify studies, a search will be performed in the following databases: PubMed, EMBASE, PsycINFO, CINAHL, LILACS, SciELO, Web of Science, Scopus, ProQuest, the Cochrane Database of Systematic Reviews through the Cochrane Library and the Epistemonikos database of systematic reviews. The searches date from inception to September 2020. The study selection process will be described using a PRISMA flow diagram, we will assess the quality of evidence in systematic reviews included and the quality of the systematic reviews themselves and the main results will be summarised in categories to provide a map of the evidence available. <h3>Ethics and dissemination</h3> No patients or other participants will be involved in this study. The results will be presented at mental health conferences and for publication in a peer-reviewed journal. <h3>Registration details</h3> The protocol was registered on the Open Science Framework (https://osf.io/myzd9/).
Computer measurement of cardiac output by dye dilution: comparison of computer, Fick, and Dow techniques
Authors: R. STENSON, L. CROUSE, D. C. HARRISON
Journal: Cardiovascular Research (1972)

Seventy-five indocyanine green dye curves were done in 27 patients, with Fick cardiac output determinations being carried out just before the dye curves. A digital computer was programmed to calculate dye cardiac output by the method of Hamilton, using four different segments of the washout portion of the curves to approximate an exponential and exclude recirculation. Comparison of computer determinations with those done manually revealed remarkably similar results for all four programmes with a standard deviation of the difference of approximately 6%. Considerations of ease of programming and economy of calculations, as well as accuracy of the results, have led to selection of two of the programmes as providing the most effective method of analysis. Computer Hamilton analysis and the Dow formula were compared with the Fick in the entire patient population and in those patients with reduced cardiac output. The Dow formula produced significantly more scatter than the Hamilton technique in both normal and low output states; there was no consistent underestimation of cardiac output by the dye method in low output states, nor when the distance between injection site and sampling site was maximized. Analysis of dye curves by digital computer provides a rapid and accurate method for multiple cardiac output determinations.
Impairment of hepatocellular mitochondrial functions in chronic hepatitis C patients with genotype 1B: Ultrastructural and biochemical findings
Authors: G. Barbaro, G. Di Lorenzo, A. Asti, M. Ribersani, G. Belloni, B. Grisorio, F. Cadario, V. Ciappina, G. Barbarini
Journal: Journal of Hepatology (2000)
Energy Expenditure and Wasting in Human Immunodeficiency Virus Infection
Authors: Derek C. Macallan, Carole Noble, Christine Baldwin, Susan A. Jebb, Andrew M. Prentice, W. Andrew Coward, Malcolm B. Sawyer, Tom J. McManus, George E. Griffin
Journal: New England Journal of Medicine (1995)

Increased expenditure of energy at rest has been considered a contributing factor to the negative energy balance and weight loss that occur in patients with human immunodeficiency virus (HIV) infection. However, the true determinant of energy balance is not resting but total energy expenditure. We sought to determine the contribution of total energy expenditure to weight changes in patients with HIV-associated wasting.
Cardiac Gene Delivery With Cardiopulmonary Bypass
Authors: Michael J. Davidson, J.Mark Jones, Sitaram M. Emani, Katrina H. Wilson, James Jaggers, Walter J. Koch, Carmelo A. Milano
Journal: Circulation (2001)

Background — Cardiac gene therapy offers the possibility of enhancing myocardial performance in the compromised heart. However, current gene delivery techniques have limited myocardial transgene expression and pose the risk of extracardiac expression. Isolation of the coronary circulation during cardiac surgery may allow for more efficient and cardiac-selective gene delivery in a clinically relevant model. Methods and Results — Neonatal piglets (3 kg) underwent a median sternotomy and cardiopulmonary bypass, followed by aortic cross-clamping with 30 minutes of cardioplegic arrest. Adenoviral vectors containing transgenes for either β-galactosidase (adeno-β-gal, n=11) or the human β 2 -adrenergic receptor (adeno-β 2 -AR, n=15) were administered through the cardioplegia cannula immediately after arrest and were allowed to dwell in the coronary circulation during the cross-clamp period. After 1 week, the animals were killed, and their heart, lungs, and liver were excised and examined for gene expression. Analysis of β-galactosidase staining revealed transmural myocardial gene expression among animals receiving adeno-β-gal. No marker gene expression was detected in liver or lung tissue. β-AR density in the left ventricle after adeno-β 2 -AR delivery was 396±85% of levels in control animals ( P &lt;0.01). Animals receiving adeno-β 2 -AR and control animals demonstrated similar β-AR density in both the liver (114±8% versus 100±9%, P =NS) and lung (114±7% versus 100±9%, P =NS). There was no evidence of cardiac inflammation. Conclusions — By using cardiopulmonary bypass and cardioplegic arrest, intracoronary delivery of adenoviral vectors resulted in efficient myocardial uptake and expression. Undetectable transgene expression in liver or lung tissue suggests cardiac-selective expression.
Reduction of unwanted submental fat with <scp>ATX</scp> ‐101 (deoxycholic acid), an adipocytolytic injectable treatment: results from a phase <scp>III</scp> , randomized, placebo‐controlled study
Authors: B. Rzany, T. Griffiths, P. Walker, S. Lippert, J. McDiarmid, B. Havlickova
Journal: British Journal of Dermatology (2013)

Background Unwanted submental fat (SMF) is aesthetically unappealing, but methods of reduction are either invasive or lack evidence for their use. An injectable approach with ATX-101 (deoxycholic acid) is under investigation. Objectives To evaluate the efficacy and safety of ATX-101 for the reduction of unwanted SMF. Methods In this double-blind, placebo-controlled, phase III study, 363 patients with moderate/severe SMF were randomized to receive ATX-101 (1 or 2 mg cm−2) or placebo injections into their SMF at up to four treatment sessions ~28 days apart, with a 12-week follow-up. The co-primary efficacy endpoints were the proportions of treatment responders [patients with ≥ 1-point improvement in SMF on the 5-point Clinician-Reported Submental Fat Rating Scale (CR-SMFRS)] and patients satisfied with their face and chin appearance on the Subject Self-Rating Scale (SSRS). Secondary endpoints included skin laxity, calliper measurements and patient-reported outcomes. Adverse events were monitored. Results Significantly more ATX-101 recipients met the primary endpoint criteria vs. placebo: on the clinician scale, 59·2% and 65·3% of patients treated with ATX-101 1 and 2 mg cm−2, respectively, were treatment responders vs. 23·0% for placebo (CR-SMFRS; P < 0·001); on the patient scale, 53·3% and 66·1%, respectively, vs. 28·7%, were satisfied with their face/chin appearance (SSRS; P < 0·001). Calliper measurements showed a significant reduction in SMF (P < 0·001), skin laxity was not worsened and patients reported improvements in the severity and psychological impact of SMF with ATX-101 vs. placebo. Most adverse events were transient and associated with the treatment area. Conclusions ATX-101 was effective and well tolerated for nonsurgical SMF reduction.
Brain-Powered Prosthetics
Authors: Joan Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fascia lata aortic valve reconstruction: long-term results in 33 patients
Authors: I. M. Breckenridge, M. P. Singh, H. H. Bentall, W. P. Cleland
Journal: Thorax (1971)

Aortic valve reconstruction with autologous fascia lata was performed in 33 patients (mean age 35 years) in 1966 and 1967. Eighty-two per cent had cusp extension rather than replacement, while 33% required additional intracardiac procedures. There were seven hospital deaths (21%) and 11 late deaths (33%), a total mortality of 54% over four years. Six late deaths followed reoperation for recurrent incompetence, and two other patients survived reoperation. Endocarditis (rickettsial, fungal, and bacterial) occurred in five cases, all required reoperation for incompetence, and four died. Sixty-nine per cent of the survivors of operation left hospital with competent valves and did better than the 31% with leaking valves in terms of late deaths, endocarditis, and reoperation for incompetence. Of the 15 patients (45%) still alive, 13 still have their original fascial valve, and of these only two (or perhaps three) have no diastolic murmur. Seven have insignificant murmurs and three have aortic incompetence. These poor results, particularly in the long term, make us sceptical about current enthusiasm for fascia lata heart valves.
Should sewage workers and carers for people with learning disabilities be vaccinated for hepatitis A?
Authors: C J Poole, A T Shakespeare
Journal: BMJ (1993)

mothers not listed on the register.This should be remembered by doctors when they identify risk indicators and formulate action plans at case con- ferences.Our study suggests that the children of women who have been assaulted are in need of increased protection.Staff in accident and emergency departments and general practitioners should be aware of the increased risk to children of victims of assault.When women seek medical treatment for injuries resulting from domestic violence the local child protection register should be checked, and if the victim or the assailant is listed the protection of the children in the family must be ensured.We thank Mr R Greenland, custodian of Avon child protection register, for his cooperation and support.
1354 GLYCEMIC VARIABILITY IS AN INDEPENDENT PROGNOSTIC FACTOR FOR DEVELOPMENT OF HEPATIC FIBROSIS IN NONALCOHOLIC FATTY LIVER DISEASE
Authors: M. Ono, M. Hashiba, H. Hyogo, Y. Ikeda, K. Masuda, R. Yoshioka, K. Munekage, T. Ochi, M. Ogasawara, A. Hirose, M. Takahashi, S. Noguchi, N. Okamoto, S. Iwasaki, K. Chayama, N. Suganuma, T. Saibara
Journal: Journal of Hepatology (2013)
Overdrive Pacing From Downstream Sites on Multielectrode Catheters to Rapidly Detect Fusion and to Diagnose Macroreentrant Atrial Arrhythmias
Authors: Chirag R. Barbhaiya, Saurabh Kumar, Justin Ng, Usha Tedrow, Bruce Koplan, Roy John, Laurence M. Epstein, William G. Stevenson, Gregory F. Michaud
Journal: Circulation (2014)

Entrainment criteria for macroreentrant arrhythmias are based on detecting fusion between tachycardia and paced wavefronts, but this is often difficult for atrial tachycardias (AT) after ablation of atrial fibrillation.With the use of a multipolar catheter, pacing was performed from electrodes within the coronary sinus showing activation later than adjacent electrodes (downstream overdrive pacing) during 66 ATs in 62 patients: 20 cavotricuspid isthmus-dependent ATs, 20 perimitral ATs, 13 focal ATs with sequential coronary sinus activation, and 13 other macroreentrant left atrial ATs. The paced cycle length was 10 to 30 milliseconds below the tachycardia cycle length (TCL), and activation at the neighboring upstream electrodes was assessed. Downstream overdrive pacing at 48 sites close to a macroreentrant circuit (PPI-TCL <40 milliseconds, where PPI is postpacing interval) produced constant fusion demonstrated by a long stimulus to upstream atrial electrogram interval (S-Au) >75% TCL and was consistent with orthodromic activation of the upstream site despite its close proximity to the pacing site. In contrast, downstream overdrive pacing at 18 sites during focal AT or remote from the macroreentrant AT circuit (PPI-TCL >40 milliseconds) always demonstrated a comparatively short S-Au <25% of TCL (12±4% versus 89±4% of TCL; P<0.001), consistent with direct activation.Selection of a downstream activation site for overdrive pacing can facilitate rapid recognition of macroreentry and proximity to the reentry circuit using a single multielectrode catheter by recognizing a PPI-TCL <40 milliseconds and S-Au >75% of TCL. Recognition of intracardiac constant fusion with this method is a novel criterion for transient entrainment.
Alexithymia and Somatic Conditions in Patients with Affective Illnesses during Lithium Prophylaxis
Authors: Janusz K.R. Rybakowski, William L. Dyson, Jay D. Amsterdam
Journal: Psychotherapy and Psychosomatics (1988)

The personality trait of alexithymia was assessed in 95 patients (35 male, 60 female) with affective illnesses, receiving lithium prophylactically, by means of Schalling-Sifneos Personality Scale (SSPS). The mean SSPS score was similar to that of the healthy population: only 8 patients had a score below 50 points. No relationship was observed between alexithymia score and age, diagnostic category (bipolar I, bipolar II, unipolar) and the duration of lithium therapy. Lower SSPS scores (i.e. high alexithymia) were found in subgroups of male patients with essential hypertension and female patients with lithium-induced obesity. The results suggest that alexithymic traits have no relationship to the pathogenesis of affective illness but may play some role in somatic symptoms emerging in affective patients on lithium prophylaxis.
Rare occurrence of the JAK2 V617F mutation in AML subtypes M5, M6, and M7
Authors: Stefan Fröhling, Daniel B. Lipka, Sabine Kayser, Claudia Scholl, Richard F. Schlenk, Hartmut Döhner, D. Gary Gilliland, Ross L. Levine, Konstanze Döhner
Journal: Blood (2006)
Lung Abscess
Authors: H. Irving Schweppe, John H. Knowles, Lewis Kane
Journal: New England Journal of Medicine (1961)

IT is the purpose of this paper to review the changing clinical picture of lung abscess as seen in one institution. A unique opportunity to do this exists at the Massachusetts General Hospital, where a background of four studies concerning 681 cases is available, covering the period 1909 to 1942.1 2 3 4 The last two reports by Sweet3 , 4 included the years between 1933 and 1942, which marked, therapeutically, the ascendancy of thoracic surgery and the beginning of the present antibiotic era. Disappointing results after the use of sulfonamides were noted.4 This report concerns the period from 1943 to 1956 and reviews the . . .
A FATAL CASE OF PARATYPHOID B SIMULATING TYPHUS FEVER
Authors: P. S. Hichens, E. J. Boome
Journal: BMJ (1918)

TIn prevalence of cerebro-spinal fever is essentially seasonal, as is well illustrated by the fact that in Ipswich, (hiring the three years 1915-1917, 26 cases occurred in the AI^rch quarter, 33 in the June quarter, 2 in the September, aud 2 in the December quarter.The maxi-mum prevalence
Predictors of the Success or failure of medical therapy in patients with chronic recurrent sustained ventricular tachycardia: A discriminant analysis
Authors: Scott R. Spielman, J. Sanford Schwartz, David M. McCarthy, Leonard N. Horowitz, Allan M. Greenspan, Laura M. Sadowski, Mark E. Josephson, Harvey L. Waxman
Journal: Journal of the American College of Cardiology (1983)
What have we learnt from targeted anti-TNF therapy?
Authors: M Feldmann, R O Williams, E Paleolog
Journal: Annals of the Rheumatic Diseases (2009)

Anti-tumour necrosis factor (anti-TNF) therapy of patients with rheumatoid arthritis dates back to 1992, when the first proof-of-principle trials were performed in London by Maini and Feldmann. Considerable studies of the mechanism of action were performed, and insights into the way in which anti-TNF therapy delivers its benefit were obtained. In this brief review, certain aspects of knowledge acquired and the many gaps will be reviewed. Focus will be on the TNF-dependent cytokine cascade and what it means, and potential new approaches to treatment. Finally, an entertaining challenge: might many or even all unmet clinical needs be dealt with through cytokine analysis?
Abstract 145: Fibulin-5 as a regulator of integrin-induced ROS production and potential target for pancreatic cancer
Authors: Mary Topalovski, Miao Wang, Rolf A. Brekken
Journal: Cancer Research (2014)

Abstract Reactive oxygen species (ROS) function as signaling molecules in pathological and normal molecular pathways. Redox homeostasis is maintained by a balance between the ROS production and ROS scavenging capacity of the cell. Extracellular matrix (ECM) proteins such as fibronectin have been shown to induce ROS upon binding to cell surface integrins, such as α5β1 integrin. Solid tumors rich in ECM such as pancreatic ductal adenocarcinoma (PDAC) display with higher levels of ROS compared to normal tissue. An attractive strategy to improve therapeutic response in PDAC is to further increase the level of ROS, thereby producing irreversible stress to tumor cells and surrounding stromal cells. Furthermore, increased ROS production has been shown to enhance the efficacy of some chemotherapeutics and might also improve the potency of anti-angiogenic therapy. We propose a novel function of the matricellular protein Fibulin-5 (Fbln5) is to regulate ROS levels during angiogenesis. Fbln5 is expressed highly in human PDAC tissue and in murine models of pancreatic cancer. We have seen that the genetic ablation of of Fbln5 results in decreased tumor growth in implant and genetic models of pancreatic cancer. Furthermore, this decrease in tumor growth is accompanied by a decrease in microvessel density. Our lab has discovered that Fbln5 reduces integrin-mediated ROS generation by competing with fibronectin for binding to α5β1 integrin. Fbln5 binds to α5β1 integrin via an RGD motif, mutation of which to RGE abolishes the Fbln5 - integrin interaction. Knock-in Fbln5RGE/RGE mice have been produced and crossed into the background of KIC mice (p48Cre/+; LSL- KrasG12D; Ink4a/Arflox/lox). By utilizing this in vivo model we will be able to elucidate the mechanism by which Fbln5 regulates tumor angiogenesis and specifically integrin-induced ROS production. In the present study, our goal is to investigate the molecular mechanism leading to increased ROS production in tumors in Fbln5RGE/RGE animals. These targeted experiments will advance our understanding of the biology of Fbln5 in pancreatic cancer and ultimately contribute to its development as a potential therapeutic target. Citation Format: Mary Topalovski, Miao Wang, Rolf A. Brekken. Fibulin-5 as a regulator of integrin-induced ROS production and potential target for pancreatic cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 145. doi:10.1158/1538-7445.AM2014-145
1162 TURMERIC CURCUMIN INHIBITS ENTRY OF ALL HEPATITIS C VIRUS GENOTYPES INTO HUMAN LIVER CELLS
Authors: A. Kusuma, C.C. Colpitts, L.M. Schang, H. Rachmawati, A. Frentzen, S. Pfaender, P. Behrendt, R.J.P. Brown, D. Bankwitz, J. Steinmann, M. Ott, P. Meuleman, T. Pietschmann, E. Steinmann
Journal: Journal of Hepatology (2013)
Antituberculous therapy and acute liver failure
Authors: F Durand, D Pessayre, M Fournier, J Belghiti, S Erlinger, J Bernuau, J McKeon, AnilM Patel, Martyn Caplin, Nick Thompson, Mark Hamilton, Neil McIntyre, Andrew Burroughs, E.L.C Ong, S.J Bourke, J White, S.C Stenton, D.J Hendrick, J.Mark FitzGerald
Journal: The Lancet (1995)