tbuckley/cabot-search huggingface dataset:
Delayed Aortic Rupture Accompanying Major Musculoskeletal Trauma
Authors: Otto E. Aufranc
Journal: JAMA (1965)

Dr. Donald Skinner: A 53-year-old man was struck by an automobile, and a few minutes later he was admitted to the Emergency Ward at the Massachusetts General Hospital. He was unconscious, and his blood pressure was 55/0 mm Hg. He had sustained multiple injuries, including open fractures of his tibia and fibula bilaterally, evidence of contusion of the right side of the temple, and a right flank hematoma. On physical examination his chest was symmetrical; his lungs were clear to percussion and auscultation, and there was no evidence of either external chest trauma or injuries to the osseous thorax. His neurological examination revealed a dilated pupil on the right, but otherwise was unremarkable. He regained consciousness, and his blood pressure returned to normal levels after he had received 1500 cc of whole blood. At this time it was also noted that there was blood behind his left ear drum which
Rheumatic Disorders in Childhood
Authors: P. J. L. Holt
Journal: Annals of the Rheumatic Diseases (1981)

The second volume of this work, like the first, is a collection of unrelated monographs by different authors on topics which the editors judge to be of particular current interst in the study and practice of rheumatic diseases.Dr Paul Dieppe gives an excellent review of crystals and their identification.Their established role in crystal synovitis is contrasted with the more conjectural part they have to play in osteoarthritis.Dr Hamilton Hall, a Canadian orthopaedic surgeon, describes the current techniques for the investigation, assessment, and treat- ment of low back pain and he quite rightly warns us of the limitations of such procedures as the CT scan and thermography.Dr J. P. Famey gives an account of enkephalins and endorphins.As he says, many questions remain to be answered about the application of these new discoveries to rheumatology, but his chapter is useful for those of us who are not abreast of the extensive literature on the subject, with 147 references.The chapter on dermatological manifestations of connective tissue disease by Professor MacKie, Dr Nelson, and Dr D. C. Dick suffers from a complete absence of illustrations and by its necessary incompleteness.Some of the statements in this chapter may be questioned, such as the opinion that systemic corticosteroids have no specific effect on the rash of Still's disease.Professor Peter Beighton gives an all too brief review of geographic variation in joint disorders.Dr Jane Schaller's chapter on the arthritides of childhood is admirable, although childhood arthritis (rather rare) and its classification are described by various authors in textbooks and numerous other recent publications, so that the editors might well have chosen another subject in its place.(Incidentally, why have rheumatological paediatricians introduced the ugly word 'pauciarticular' in place of 'oligoarticular' which we have all used happily for years?If they don't like Greek-Latin hybrids they should be consistent and chartge 'monoarticular' to 'uniarticular' and 'polyarticular' to 'multiarticular').The Ebringer brothers summarise their controversial ideas on cross-reactivity between the B27 gene and klebsiella.Dr Heather M. Dick writes on HLA and seronegative arthropathies-a good review, although again many of her readers will by now be reasonably familiar with what she has to say, and rather more emphasis on recent work relating for example to rheumatoid arthritis and drug toxicity would have been interesting.It will be seen that the whole book savours refreshingly of clinical medicine, and all the contributions will be read with interest by rheumatologists.They are fully referenced and indexed.
ULTRASTRUCTURAL FEATURES OF EPIDERMIS OF A 14 mm. (6 WEEKS) HUMAN EMBRYO
Authors: A. S. BREATHNACH, JAQUELINE ROBINS
Journal: British Journal of Dermatology (1969)

Journal Article ULTRASTRUCTURAL FEATURES OF EPIDERMIS OF A 14 mm. (6 WEEKS) HUMAN EMBRYO Get access A. S. BREATHNACH, A. S. BREATHNACH Department of Anatomy, St. Mariy's Hospital Medical School, London, W.2 Search for other works by this author on: Oxford Academic Google Scholar JAQUELINE ROBINS JAQUELINE ROBINS Department of Anatomy, St. Mariy's Hospital Medical School, London, W.2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 7, 1 July 1969, Pages 504–516, https://doi.org/10.1111/j.1365-2133.1969.tb16025.x Published: 01 July 1969 Article history Accepted: 27 November 1968 Published: 01 July 1969
5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries
Authors: A. H Chester, G. R Martin, M. Bodelsson, B. Arneklo-Nobin, S. Tadjkarimi, K. Tornebrandt, M. H Yacoub
Journal: Cardiovascular Research (1990)

Journal Article 5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries Get access Adrian H Chester, Adrian H Chester Correspondence to: Professor Yacoub Search for other works by this author on: Oxford Academic PubMed Google Scholar Graeme R Martin, Graeme R Martin Search for other works by this author on: Oxford Academic PubMed Google Scholar Mikeal Bodelsson, Mikeal Bodelsson Search for other works by this author on: Oxford Academic PubMed Google Scholar Brigitta Arneklo-Nobin, Brigitta Arneklo-Nobin Search for other works by this author on: Oxford Academic PubMed Google Scholar Samad Tadjkarimi, Samad Tadjkarimi Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenneth Tornebrandt, Kenneth Tornebrandt Search for other works by this author on: Oxford Academic PubMed Google Scholar Magdi H Yacoub Magdi H Yacoub Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 11, November 1990, Pages 932–937, https://doi.org/10.1093/cvr/24.11.932 Published: 01 November 1990 Article history Received: 20 December 1989 Accepted: 06 June 1990 Published: 01 November 1990
Points from Letters: Upgrading V.D. Departments
Authors: F. M. Lanigan-O'Keefe
Journal: BMJ (1970)

BITISH(often in his prime) rather than take the risk of a breakdown in health in the sub- sequent five years.Compare the lot of the man who gets an award, say, at 50.Not only can he afford to ease off earlier, he can also spare the time to attend clinical meetings, administrative committees, and write papers, and in due course this bears the fruit of an even higher award.Although the system is supposedly
A prospective, blinded analysis of thymidylate synthase and p53 expression as prognostic markers in the adjuvant treatment of colorectal cancer
Authors: S. Popat, Z. Chen, D. Zhao, H. Pan, N. Hearle, I. Chandler, Y. Shao, W. Aherne, R.S. Houlston
Journal: Annals of Oncology (2006)
REPORT ON ACUTE ILLNESS AMONG RURAL MATTRESS MAKERS USING LOW GRADE, STAINED COTTON
Authors: PAUL A. NEAL
Journal: JAMA (1942)

This report deals with an acute illness among workers in rural mattress making projects using low grade cotton. The history of the outbreaks of illness, distribution of cases, estimated number of persons involved, nature of the illness and description of the investigations undertaken to determine the cause of the illness are presented. Numerous reports of sudden outbreaks of acute illness occurring among workers on rural mattress making projects were received by the U. S. Public Health Service throughout the period from March to December 1941. Outbreaks of a similar illness were also reported in one cotton mill and in several cottonseed processing plants. Illness invariably followed the use of a very low grade, dusty, stained cotton of the 1940 crop. The rural mattress making projects, sponsored by the U. S. Department of Agriculture, were part of a program designed to reduce the cotton surplus and to benefit farm families. Rural
Abstract P4-03-06: Initial ex-vivo study of the ability of an in situ fluorescence spectroscopy probe to distinguish benign from malignant breast tissues
Authors: M-C Mathieu, H Moniz-Koum, Y Vincent, A Toullec, C Balleyguier, T Eyrignoux, P Vielh, F Chatellier, L Al Chab, M-P Fontaine-Aupart, R Farcy, S Delaloge
Journal: Cancer Research (2013)

Abstract Background: The native fluorescence spectra of human cancerous and normal breast tissues under the selected excitation of a 405 nm light should differ according to their different content of NAD(P)H, FAD, collagen or retinol and derived fluorophores. Nodea Medical has developed an in situ probe, Probea®, installed in a 25-Gauge needle, which is able to measure endogenous tissue fluorescence under 405 nm specific wavelength. Tissues are excited by this blue light; their back-production of fluorescence (around 480 nm) is caught and immediately analyzed. The objectives of the present preclinical study are to evaluate the ability of the Probea® probe to distinguish benign versus malignant breast lesions among freshly harvested ex-vivo surgical samples, and to evaluate the fluorescence behaviour of adjacent and remote normal tissues among cancer specimens. Methods: Fresh breast samples coming out of the operating room were harvested and analyzed prior to pathological fixation. Surgical specimens included mastectomies, lumpectomies, and plastic surgeries in different malignant or non-malignant situations. For each of them, the probe was placed within the main target surgical lesion, as well as within surrounding normal epithelial and fat tissues, and remote normal tissues where available (mastectomies or reduction mammoplasties). We aimed at measuring different parameters of the endogenous fluorescence at each measurement point: maximum intensity, peak wavelength, level of signal stability, growth or spontaneous decay in a fixed position. Fluorescence signals harvested were compared to the detailed pathological analyses of each area explored within the surgical samples. Results : 49 fresh breast samples were harvested and analyzed, of which 40 were from patients with cancer and 9 from patients without cancer. The presence of a fluorescence signal within the main lesion was overall strongly associated with a cancer diagnosis (N = 40/49 malignant lesions versus 0/9 benign lesions, p = 0.001). The positive predictive value of the test in this preliminary series is 98%, whereas the negative predictive value is 100% analyzing the maximum fluorescence intensity with a cut-off of 1000. Interestingly, normal adjacent fat tissues surrounding and remote from breast cancer lesions also produced fluorescence which could also be considered as criteria to define malignancy. Complete analyses of multiple parameters are ongoing. Conclusion: In this initial preclinical study, the Probea® probe has shown an elective ability to distinguish benign and malignant lesions. Particularly, its negative predictive value appears very promising. A clinical study to confirm these findings is planned. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-03-06.
Charles Peter Beynon Brook
Authors: Tom Dening
Journal: BMJ (2004)

Former consultant in old age psychiatry Cambridge (b Bromley 1928; q Guy's Hospital, London, 1952; MD, FRCPsych), d 18 December 2003.​2003.




Figure 1




Peter Brook was the first old age psychiatrist in Cambridge. He inherited numerous rambling wards at the old Fulbourn Hospital and founded the present thriving and much grown service. This included the development of integrated multidisciplinary community resource teams, long before the current vogue for interagency working. Always a supporter of research, he was instrumental in establishing the Hughes Hall project for later life, an epidemiological study of nearly 3000 over 75s in Cambridge. Although he developed myeloma soon after his retirement, he remained active as an organiser of the local branch of the University of the Third Age and with work on naval history. He leaves a wife, Joy; two children; and two grandsons.
Prone positioning in acute respiratory distress syndrome: a multicenter randomized clinical trial
Authors: Rafael Fernandez, Xavier Trenchs, Jordi Klamburg, Jon Castedo, Jose Manuel Serrano, Guillermo Besso, Juan Pedro Tirapu, Antonio Santos, Arantxa Mas, Manuel Parraga, Paola Jubert, Fernando Frutos, Jose Manuel Añon, Manuela Garcia, Fernando Rodriguez, Joan Carles Yebenes, Maria Jesus Lopez
Journal: Intensive Care Medicine (2008)
Seasonal variation in sudden infant death syndrome and bronchiolitis--a common mechanism?
Authors: R Gupta, P J Helms, I T Jolliffe, A S Douglas
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

The purpose of this study was to compare epidemiologic features of sudden infant death syndrome (SIDS) and bronchiolitis and to apply statistical examination in order to examine the hypothesis that similar mechanisms could be at work in both conditions. The setting was Scotland from 1982 through 1990. We compared 1,211 deaths from SIDS with 10,058 hospital admissions for bronchiolitis in infancy. The comparisons included age, sex ratio, and seasonality. The sex ratios were similar (SIDS [M:F]:1.61:1; bronchiolitis: 1.63:1), but age distribution was different (chi 2 = 104.6, p < 0.001). When monthly rates throughout the year were compared using correlation of residuals from average season variation and by autocorrelation of residual series, no significant relationships were found between the two conditions (r2 = 0.0004). Once the seasonal pattern common to both conditions was accounted for, SIDS was not autocorrelated between months whereas bronchiolitis exhibited a high level of autocorrelation indicating an epidemic pattern for the latter but not for the former. While a common seasonal variation may indicate some shared etiologic factors associated with winter season, the two conditions do not appear to be closely related. The hypothesis that a common host susceptibility is at work is not supported. Further investigations of seasonal influences are warranted.
Severe Granulocytopenia with Cimetidine and Phenytoin
Authors: ELIZABETH SAZIE
Journal: Annals of Internal Medicine (1980)

Letters1 July 1980Severe Granulocytopenia with Cimetidine and PhenytoinELIZABETH SAZIE, M.D., JEFFRY P. JAFFE, M.D.ELIZABETH SAZIE, M.D.Search for more papers by this author, JEFFRY P. JAFFE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-1-151_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Several reports (1-3) implicate cimetidine as the cause of severe granulocytopenia. Phenytoin causes a variety of hematologic toxicities, although granulocytopenia has been exceedingly rare (4). We report a case in which a patient receiving both medications in high doses developed severe granulocytopenia and signs of an idiosyncratic hypersensitivity reaction.A 17-year-old male sustained a subdural hematoma on 18 November 1979. When he was admitted to the hospital, his hemoglobin was 17.2 g/dL; leukocyte count 23 700 cells/mm3(10% band forms, 69% segmented forms, 12% lymphocytes, 9% monocytes); and platelets appeared normal. The subdural hematoma was evacuated, and...References1. CHANGMORRISON HS. Bone-marrow suppression associated with cimetidine. Ann Intern Med. 1979;91:580. LinkGoogle Scholar2. KLOTZKAY SB. Cimetidine and agranulocytosis. Ann Intern Med. 1978;88:579-80. Letter. LinkGoogle Scholar3. FRESTON J. Cimetidine and granulocytopenia. Ann Intern Med. 1979;90:264-5. Editorial. LinkGoogle Scholar4. TSANMEHLMANGREENBELL MDRW. Dilantin®, agranulocytosis, and phagocytic marrow histiocytes. Ann Intern Med. 1976;84:710-1. LinkGoogle Scholar5. AL-KAWASLENESSACHER FBR. Cimetidine and agranulocytosis. Ann Intern Med. 1979;90:992-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Maricopa County Hospital Phoenix, AZ 85008 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHaematological Adverse Effects of Histamine H2-Receptor AntagonistsRanitidine-Induced Granulocytopenia: Recurrence with Cimetidine AdministrationALAN F. LIST, M.D., DAVID H. BEAIRD, M.D., THOMAS KUMMET, M.D.Adverse Reactions and Interactions with H2-Receptor AntagonistsSevere thrombocytopenia associated with phenytoin and cimetidine therapyCimetidine suppression of CFU-C in malesReview of Cimetidine Drug InteractionsLeukozytopenien — AgranulozytoseAntihistamines 1 July 1980Volume 93, Issue 1_Part_1Page: 151-152KeywordsHemoglobinHypersensitivityLymphocytesMonocytesPlateletsToxicity Issue Published: 1 July 1980 PDF DownloadLoading ...
751-1 Efficacy of Tranilast on Restenosis After Coronary Angioplasty: is There Any Rebound Phenomenon After Ceasing Tranilast at 3 Months?
Authors: Kinzo Ueda, Hideo Tamai, Yung-Sheng Hsu, Shinji Ono, Shozo Tanaka, Kunihiko Kosuga, Masaharu Okada, Myou-u Wang, Seiichiro Motohara, Hiromu Uehata
Journal: Journal of the American College of Cardiology (1995)
A Primary Care Home for Americans
Authors: Kevin Grumbach, Thomas Bodenheimer
Journal: JAMA (2002)

This article--the first in a series on primary care--outlines the daunting challenges facing primary care today. Most people in the United States desire a primary care "home" to provide for and coordinate their health care needs. Yet primary care is endangered by physician stress, inadequate performance in managing chronic illness, and inability to provide prompt access and reliable continuity of care. Fundamental redesign is needed to improve access to and quality of care while easing physicians' workload without causing major increases in health care costs.
Pulmonary mechanics and surfactant measurement in canine lungs following reimplantation
Authors: J. C. R. Lincoln, N. D. Barnes, T. Gould, E. O. R. Reynolds
Journal: Thorax (1970)

The left lung was reimplanted in 18 dogs. Failure of the venous anastomosis was the chief technical complication. Thirteen dogs survived until killed from eight days to 15 weeks after the operation. There was an immediate fall in total pulmonary compliance following the procedure, then a return to near normal within eight days. Surfactant and lung stability were normal. In each case there was a marked reduction in the gas volume of the reimplanted lung.
Epidermolysis bullosa acquisita. Association with amyloidosis and multiple myeloma
Authors: Donald L. Trump, Herbert Allen, Jean Olson, John Wright, Richard L. Humphrey
Journal: JAMA (1980)

EPIDERMOLYSIS bullosa acquisita (EBA) is a nonheritable, noninflammatory, subepidermal mechanobullous disease of adults, characterized by the appearance of cutaneous blisters and ulcers after minor trauma.<sup>1</sup>Epidermolysis bullosa acquisita occurred in an elderly woman as the initial manifestation of amyloidosis and multiple myeloma. <h3>Report of a Case</h3> An 81-year-old woman was admitted to The Johns Hopkins Hospital with fractures of the left humerus and left femur and denuded areas of skin in both axillae and over the left hip. For two years before admission, the patient had experienced easy bruising and fragile skin. Cutaneous blisters formed after minimal skin trauma, and with mild trauma, patches of skin were completely avulsed. There had been no infections in the areas of injured skin, and they healed normally. There was no family history of skin disease. On the evening of admission, the patient had risen from bed and fallen to the floor. She experienced
The Patient-Centered Medical Home
Authors: Diane R. Rittenhouse, Stephen M. Shortell
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
695 PATIENTS WITH HEPATOCELLULAR CARCINOMA (HCC) WITHOUT CIRRHOSIS HAD OFTEN UNDETECTABLE RISK FACTORS AND A MORE ADVANCED DISEASE AT DIAGNOSIS
Authors: G. Brancaccio, M. Tommasini, F. Brunello, V. Di Marco, G. Pinzello, T. Stroffolini, F. Trevisani, G.B. Gaeta
Journal: Journal of Hepatology (2012)
Compensating Physicians for Telephone Calls
Authors: Stephen Radecki
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The recent article by Dr Sorum<sup>1</sup>proposing compensation of physicians for their provision of telephone patient care relies on somewhat problematic assumptions about the relationship between telephone patient management and in-person medical care. Whereas continued growth in the proportion of patients covered by capitation payments under managed care will probably make the compensation question less of an issue in the future, it is important to recognize that telephone care has not been found to be used as a substitute for in-person care to the extent implied by Sorum. In advocating for insurance coverage of telephone care, the American Society of Internal Medicine (ASIM) has developed guidelines that propose payment only for telephone calls that meet the following criteria for separate remuneration: the call must involve evaluation of a new problem, along with a medical decision; it must save the patient from an office or emergency department
Public health education campaigns are worth while.
Authors: J C Catford, I A Dillow, D Nutbeam, W E Waters, M C Woolaway
Journal: BMJ (1984)

<h3>Abstract</h3> The majority of population genetic theory assumes fully haploid or diploid organisms with obligate sexuality, despite complex life cycles with alternating generations being commonly observed. To reveal how natural selection and genetic drift shape the evolution of haploid-diploid populations, we analyze a stochastic genetic model for populations that consist of a mixture of haploid and diploid individuals, allowing for asexual reproduction and niche separation between haploid and diploid stages. Applying a diffusion approximation, we derive the fixation probability and describe its dependence on the reproductive values of haploid and diploid stages, which depend strongly on the extent of asexual reproduction in each phase and on the ecological differences between them. <h3>Highlight</h3> -Classical models consider fully haploid or diploid populations -We model haploid-diploid life cycles allowing for asexual reproduction -We obtain the fixation probability of alleles subject to selection and drift -Reproductive values of haploid and diploid stages shape their evolution