Cinchophen Hypersensitiveness*†
Authors: CHARLES L. SHORT
Journal: Annals of Internal Medicine (1933)

Article1 May 1933Cinchophen HypersensitivenessA Report of Four Cases and a ReviewCHARLES L. SHORT, M.D., WALTER BAUER, M.D., F.A.C.P.CHARLES L. SHORT, M.D.Search for more papers by this author, WALTER BAUER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-11-1449 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAlthough cinchophen and its compounds have been used in medicine for about twenty-four years, only recently have possible dangers from this drug been at all well known to the profession. While scattered reports of comparatively mild toxic side-actions are found in the literature from 1913 on, Worster-Drought's1case (published in 1923) of toxic hepatitis due to atophan was the first to call attention to this most serious complication of cinchophen therapy. Three years later, Evans,2Glover,3and Willcox4added additional cases to the British literature. In this country, Miss F. M. Painter, Assistant Editor of the Case Records of...Bibliography1 WORSTER-DROUGHT C: Atophan poisoning, Brit. Med. Jr., 1923, i, 148-149. Google Scholar2 EVANS G: Atophan derivatives in rheumatism, Brit. Med. Jr., 1926, ii, 93. CrossrefGoogle Scholar3 GLOVER LG: Atophan derivatives in rheumatism, Brit. Med. Jr., 1926, ii, 136. CrossrefGoogle Scholar4 WILLCOX WH: Atophan derivatives in rheumatism, Brit. Med. Jr., 1926, ii, 273-274. CrossrefGoogle Scholar5 CABOT RC: Case records of the Massachusetts General Hospital, Boston Med. and Surg. Jr., 1925, xccii, 1122-1126. CrossrefGoogle Scholar6 RABINOWITZ MA: Atrophy of liver due to cinchophen preparations, Jr. Am. Med. Assoc., 1930, xcv, 1228-1233. CrossrefGoogle Scholar7 MALLORY FB: Cirrhosis of the liver; five different types of lesion from which it may arise, Johns Hopkins Hosp. Bull., 1911, xxii, 69-75. 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SHORT, M.D.; WALTER BAUER, M.D., F.A.C.P.Affiliations: Boston, Massachusetts*Received for publication July 6, 1932.†From the Medical Clinic of the Massachusetts General Hospital. (This is publication No. 8 of the Robert W. Lovett Memorial for the study of crippling disease, Harvard Medical School, Boston, Massachusetts). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySynthesis, Docking, ADME-Tox Study of 2-(2-(2-Chlorophenyl)quinoline-4-carbonyl)- N -substituted hydrazinecarbothioamide Derivatives and Their Biological EvaluationREFERENCESMonitoring Adverse Reactions to Drugs: Toward a Therapeutic AuditTOXIC HEPATITIS AND AGRANULOCYTOSIS DUE TO CINCHOPHEN*PETER STERNLIEB, B.S., SYLVAN H. EISMAN, M.D.Allergy to DrugsAcute Yellow Atrophy Following Cinchophen AdministrationIDIOSYNCRATIC FEBRILE REACTIONS TO THIOURACIL: CLINICAL CHARACTERISTICS AND POSSIBLE PHARMACOLOGIC SIGNIFICANCE*JANET W. MCARTHUR, M.D., RULON W. RAWSON, M.D., J. H. MEANS, M.D., F.A.C.P.Idiosynkrasien 1 May 1933Volume 6, Issue 11Page: 1449-1464KeywordsDrugsHepatitis ePublished: 1 December 2008 Issue Published: 1 May 1933 PDF downloadLoading ...