tbuckley/cabot-search huggingface dataset:
Reply to Dr. Maclean's Observations in his Critical Examination of Dr. Munro's Views on Malarial Fevers, etc
Authors: C. F. Oldham
Journal: BMJ (1875)

wbicli sbouldl then be united in the middle line, so as to form a basis of support for a subsequent superstructure of soft parts.Such a method might, I believe, be usefuLlly had recoutrse to in certain cases of partial loss of the organ ; buLt, oln fuLrther consicleration, I wras doubtftul Nvhether it would be very serviceable in the present case, in which both bones and cartilages ha(l to be pr-ovided for.'the idea of using a portion of one of the patient's fingers then pre- sented itsclf.The object to be secured being the provision of a support which slhouldlhave prominence an(d resistance, an(d at the same time be capable of assisting in the niutrition of a ftuture coverin-of skin wvith which it would be invested, my tlhoughts were at first directed to the possibility of transplanting, a toe, as in such respects suitable.At the suggestion, however-, of Mr. Peter Tytler, the house-surgeon, a finger seemed mtuch more feasible; and, as a portion onily would probably be required, this appeared to be a small loss, if a nose coulkI thereby be gained.I, therefore, explainied the matter to the patient, and, with her sanction, determiinie(I to trv M\r.Tytler's proposal.Accordinigly, oni December iotlh, I made an incision alongT the middle of the palmiiar aspect of the (listal phalanx of the left forefinger, vith a transverse incision at its base, an(l reflected two lateral flaps.The mnargini of the n-asal cavity wvas then (lenuiled, anid the skin slightly raised from the bone, so as to allow of its being somewhat everted.In this way, a tolerably broad fresh surface was secured to oppose the flaps from the finger.The parts wvere then carefully stitched together, the arm beinog supported by long strips of plaster passed round the neck, over the armii, and uni(dcr the elbow.A strip of plaster wvas also passed rounnd the lhead anid over the face ; but it wvas found in a (lay or two that this wvas of little service, and it wRas afterwards discarded.'T'he patient was put to bed, antd enjoined to be as careful as possible
Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples
Authors: J Cloos, B F Goemans, C J Hess, J W van Oostveen, Q Waisfisz, S Corthals, D de Lange, N Boeckx, K Hählen, D Reinhardt, U Creutzig, G J Schuurhuis, Ch M Zwaan, G J L Kaspers
Journal: Leukemia (2006)
Urinary Complications After Bunamiodyl
Authors: J. George Teplick
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The validity of Dr. Gunn's conclusions in "Urinary Complications Following Bunamiodyl" (<i>JAMA</i><b>175</b>:911 [March 11] 1961), seems open to question. Other investigators and myself (Teplick, J. G.; Adelman, B. P.; and Steinberg, S. B.:<i>Amer J Roentgenol</i><b>80</b>:961 [Dec.] 1958) have reported on the use of butamiodyl in over 6,000 patients, and have noted no apparent urinary complications. Dr. Gunn's first case was a 63-year-old man, with an obvious prostatic problem and with an elevated blood urea nitrogen level of 22 mg.%. After 2 larger than usual doses of butamiodyl, elevation and fluctuation of the BUN and increase in urinary symptoms were noted. Recognizing natural fluctuations in prostatic disease, can we confidently name the drug as culprit? The second patient, a 69-year-old man with unexplained anemia, BUN of 29 mg.%, albuminuria, and repeated vomiting, was given 24 gm. of butamiodyl within 48 hours, followed by
Fatal Aplastic Anemia Resulting From Flucytosine
Authors: Richard Meyer
Journal: JAMA (1974)

THE use of flucytosine (5-FC) as an alternative to amphotericin B in the treatment of cryptococcal meningitis has recently been advocated.<sup>1,2</sup>Although physicians have been counselled to watch for the toxic effects of flucytosine on the kidney, liver, and bone marrow, emphasis has been placed on the ease of administration, good diffusion, and relative lack of toxicity of flucytosine as contrasted with amphotericin B.<sup>1,2</sup>We report a case of aplastic anemia that resulted from flucytosine therapy. <h3>Report of a Case</h3> A 59-year-old man with diabetes mellitus was transferred to the hematology service of the Veterans Administration Hospital, Bronx, NY, for evaluation of pancytopenia. The patient, a weekend pigeon feeder, had been well until August 1970, when he was admitted to this hospital because of headache, nausea, and vomiting. Cerebrospinal fluid culture disclosed<i>Cryptococcus neoformans</i>. The patient was treated with a total dose of 1,455 mg of amphotericin B.
Medicare
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1999)

When Medicare was enacted in 1965 as the health care linchpin of President Lyndon Johnson's Great Society, its architects considered this insurance program for the elderly only an interim step toward the broader goal of universal health care coverage.1 That goal has never been achieved, although Medicare is the nation's single largest source of payment for medical care, insuring 39 million beneficiaries against the financial consequences of acute illness. Since Congress established the program, the benefits covered by Medicare have remained largely unchanged, with the exception of a few added preventive services, and they are certainly inadequate by current medical . . .
Pneumococcal Antigen and Pneumococcal Infection
Authors: Ruth A. Rabinovitch, Edmund H. Duthie, Steven R. Gambert, Beverly Priefer, Michael W. Rytel
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 January 1983Pneumococcal Antigen and Pneumococcal InfectionRUTH A. RABINOVITCH, M.D., EDMUND H. DUTHIE, M.D., STEVEN R. GAMBERT, M.D., BEVERLY PRIEFER, M.S., MICHAEL W. RYTEL, M.D.RUTH A. RABINOVITCH, M.D.Search for more papers by this author, EDMUND H. DUTHIE, M.D.Search for more papers by this author, STEVEN R. GAMBERT, M.D.Search for more papers by this author, BEVERLY PRIEFER, M.S.Search for more papers by this author, MICHAEL W. RYTEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-1-113_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Streptococcus pneumoniae is the commonest cause of bacterial pneumonia in the elderly (1), and many elderly patients are receiving the new pneumococcal vaccine (2). We have been interested in whether pneumococcal antigens in the vaccine could lead to false-positive results when serum and urine samples from vaccine recipients were tested for pneumococcal polysaccharide using counterimmunoelectrophoresis or coagglutination.We studied 22 residents aged 52 to 92 years at the Wood Veterans Administration Medical Center Nursing Home, after their initial inoculation with pneumococcal vaccine. Blood was drawn 2 to 4 hours and 1 day after vaccination; spontaneously voided urine...References1. AUSTRIANGOLD RJ. Pneumococcal bacteremia with especial reference to bacteremic pneumococcal pneumonia. Ann Intern Med. 1964;60:759-76. LinkGoogle Scholar2. AUSTRIAN R. Pneumococcal infection and pneumococcal vaccine. N Engl J Med. 1977;297:938-9. CrossrefMedlineGoogle Scholar3. COONRODRYTEL JM. Detection of type-specific pneumococcal antigens by counterimmunoelectrophoresis: I. Methodology and immunologic properties of pneumococcal antigens. J Lab Clin Med. 1973;81:770-7. MedlineGoogle Scholar4. EDWARDSKILPATRICKHOOPER EMD. Rapid detection of pneumococcal antigens in sputum and blood serum using a coagglutination test. Milit Med. 1980;145:256-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1983Volume 98, Issue 1Page: 113-114KeywordsAntigensBacterial pneumoniaElderlyNursing administrationNursing homesPolysaccharidesStreptococcal infectionsStreptococcusUrineVaccines Issue Published: 1 January 1983 PDF downloadLoading ...
Laughing All The Way To The Bank
Authors: Samuel Vaisrub
Journal: JAMA (1974)

Physicians have been, for long, favorite targets of the layman's humor. Look at ludicrous literary caricatures like Diaphorus in Molière's<i>Le Medicin Malgré Lui</i>or Bob Sawyer in Dickens'<i>The Pickwick Papers</i>; and for jocular epigrams, remember "doctors bury their mistakes," or amusing tales told by stock brokers about the vagaries of physician-investors. Have doctors retaliated in kind? Have they matched their wits with their deriders? Although not lacking in a sense of humor, doctors do not, as a rule, exercise it in their relations with hospital administrators, government officials, drug manufacturers, and especially—repeat, especially—patients. Had O. Henry been a doctor he would have been rapped on the knuckles for his famous remark that fat women and patients with hay fever attest to God's sense of humor. Even news media operators enjoy a kind of diplomatic immunity from barbs of medical wit, despite their often grotesque medical news coverage. Against
Smallpox Vaccination for Chronic Herpetic Ulcers
Authors: Troy G. Rollins
Journal: JAMA (1970)

To the Editor.—  The article by doctors J. M. Neff and J. M. Lane Vaccinia Necrosum Following Smallpox Vaccination for Chronic Herpetic Ulcers, ( 213 :123, 1970) should have added to it In people with diseases affecting the reticuloendothelial system or those receiving immuno-suppressive   An all-inclusive statement that smallpox vaccination for chronic herpetic ulcers is  potentially dangerous practice and a form of supposed therapy that should be discontinued is inappropriate.  I do not believe that people using this modality of therapy in patients with chronic recurrent herpes simplex feel that it is  panacea, but I am sure that those few individuals who have been helped by the procedure would take issue with the authors. It has been the experience of most people using this therapy that only the occasional patient who suffers from multiple and frequent recurrent herpetic episodes receives any value from smallpox vaccination therapy. Even though
The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
Authors: Verena Keitel, Kenko Cupisti, Christoph Ullmer, Wolfram T. Knoefel, Ralf Kubitz, Dieter Häussinger
Journal: Hepatology (2009)

Abstract TGR5 (Gpbar-1) is a plasma membrane-bound, G protein–coupled receptor for bile acids. TGR5 messenger RNA (mRNA) has been detected in many tissues, including rat cholangiocytes and mouse gallbladder. A role for TGR5 in gallstone formation has been suggested, because TGR5 knockout mice did not develop gallstones when fed a lithogenic diet. In this study, expression and localization of TGR5 was studied in human gallbladders. TGR5 mRNA and protein were detected in all 19 gallbladders. Although TGR5 mRNA was significantly elevated in the presence of gallstones, no such relation was found for TGR5 protein levels. In order to study the localization of TGR5 in human gallbladders, a novel antibody was generated. The receptor was localized in the apical membrane and the rab11-positive recycling endosome of gallbladder epithelial cells. Furthermore, the TGR5 staining colocalized with the cyclic adenosine monophosphate–regulated chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) and the apical sodium-dependent bile salt uptake transporter, suggesting a functional coupling of TGR5 to bile acid uptake and chloride secretion. Stimulation with bile acids significantly increased cyclic adenosine monophosphate concentration in human gallbladder tissue. Incubation of gallbladder epithelial cells with a TGR5 agonist led to a rise of N -(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide (MQAE)-fluorescence, suggestive of a decrease in intracellular chloride concentration. The TGR5 agonist–dependent increase in MQAE-fluorescence was absent in TGR5 knockout mice or in the presence of a CFTR inhibitor, indicating that TGR5 mediates chloride secretion via activation of CFTR. The presence of the receptor in both the plasma membrane and the recycling endosome indicate that TGR5 can be regulated by translocation. Conclusion: The data suggest a role for TGR5 in bile acid–induced fluid secretion in biliary epithelial cells. (Hepatology 2009.)
Is clinical breast examination an acceptable alternative to mammographic screening?
Authors: I. Mittra
Journal: BMJ (2000)

Breast cancer screening and mammography have almost become synonymous in the public perception, yet this should not necessarily be the case. Ideally, a screening tool for breast cancer would reduce mortality from breast cancer while having a low false alarm rate and being relatively cheap. Screening should not be at the expense of the symptomatic services nor inappropriately divert scarce resources away from equally deserving areas of the NHS that are less politically sensitive.1

An ideal screening test would be simple, inexpensive, and effective. Of the three modalities of breast cancer screening—breast self examination, clinical breast examination, and mammography—breast self examination fulfils the first two criteria, but early results of two randomised trials conducted in Russia and China suggest that it would not be effective in reducing mortality from breast cancer. 2 3 Clinical breast examination is also relatively simple and inexpensive, but its effectiveness in reducing mortality from breast cancer has not been directly tested in a randomised trial. Mammography is complex, expensive, and only partially effective. We believe that there is sufficient circumstantial evidence to suggest that clinical breast examination is as effective as mammography in reducing mortality from breast cancer and that the time has come to compare these two screening methods directly in a randomised trial.

#### Summary points

The goal of breast screening is to prevent death and not simply to detect cancers by mammography

Mammography does detect some cancers “early,” but many of these are not potentially lethal and their detection causes needless anxiety

Clinical breast examination is more likely to detect cancers that are potentially lethal

Results of the second Canadian national breast screening study suggest that mammographic detection of cancers that are not palpable does not affect mortality

New GMC guidelines on informed consent state that women in the NHS breast screening programme should …
Effectiveness of Early Intensive Therapy on β-Cell Preservation in Type 1 Diabetes
Authors: Bruce Buckingham, Roy W. Beck, Katrina J. Ruedy, Peiyao Cheng, Craig Kollman, Stuart A. Weinzimer, Linda A. DiMeglio, Andrew A. Bremer, Robert Slover, William V. Tamborlane
Journal: Diabetes Care (2013)

To assess effectiveness of inpatient hybrid closed-loop control (HCLC) followed by outpatient sensor-augmented pump (SAP) therapy initiated within 7 days of diagnosis of type 1 diabetes on the preservation of β-cell function at 1 year.Sixty-eight individuals (mean age 13.3 ± 5.7 years; 35% female, 92% Caucasian) were randomized to HCLC followed by SAP therapy (intensive group; N = 48) or to the usual-care group treated with multiple daily injections or insulin pump therapy (N = 20). Primary outcome was C-peptide concentrations during mixed-meal tolerance tests at 12 months.Intensive-group participants initiated HCLC a median of 6 days after diagnosis for a median duration of 71.3 h, during which median participant mean glucose concentration was 140 mg/dL (interquartile range 134-153 mg/dL). During outpatient SAP, continuous glucose monitor (CGM) use decreased over time, and at 12 months, only 33% of intensive participants averaged sensor use ≥6 days/week. In the usual-care group, insulin pump and CGM use were initiated prior to 12 months by 15 and 5 participants, respectively. Mean HbA1c levels were similar in both groups throughout the study. At 12 months, the geometric mean (95% CI) of C-peptide area under the curve was 0.43 (0.34-0.52) pmol/mL in the intensive group and 0.52 (0.32-0.75) pmol/mL in the usual-care group (P = 0.49). Thirty-seven (79%) intensive and 16 (80%) usual-care participants had a peak C-peptide concentration ≥0.2 pmol/mL (P = 0.30).In new-onset type 1 diabetes, HCLC followed by SAP therapy did not provide benefit in preserving β-cell function compared with current standards of care.
Effective Frontal Plane Vectorcardiogram of <i>Rana Pipiens</i>
Authors: DANIEL A. BRODY
Journal: Circulation Research (1957)

A technic is described which provides highly accurate registration of the effective frontal plane vectorcardiogram of Rana pipiens . A comparative study with one of the conventional vectorcardiographic systems illustrates some of the inherent defects of the latter method. Another potentially useful aspect of effective vectorcardiograms is that they may be calibrated in a manner which presents heart vectors in their physically correct units of dimension.
Public Opinion and AIDS
Authors: Robert J. Blendon
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Mother of Psycho-Oncology' Discusses Field's Need for Parity and People Power
Authors: R. S. Tuma
Journal: JNCI Journal of the National Cancer Institute (2004)

continues to lead the field in both the United States and throughout the world.Her goal is to make behavioral care more accessible as well as to increase research in the field. How did you get involved in psychooncology?I went into psychiatry, but I found myself interested in how people who are psychologically healthy face catastrophic events in their lives, like serious illness.I then married and stayed home with children.Meanwhile, my husband Jim [James Holland, M.D.], who was chairman of the Cancer and Leukemia Group B, would bring colleagues home to dinner and they would talk about the new treatments and protocols that were ongoing.I would ask, "But how do these patients feel about this?" and they would say, "We don't have time to talk about how they feel.We have to look at the toxicities in terms of the blood and kidneys, and so on."It was then that I vowed that when the children got a little bigger and I had more time, I would look at this.At that time, there was virtually nothing going on [in mental health for cancer patients] at most places.So when I came to Memorial I was able to set up the first full-time academic service in a cancer center, certainly in the United States and probably in the whole world.Around 1977, we began in this country to see better cancer treatments, to begin to see people being cured of cancer, and we began to tell people their diagnosis and treatment options.The taboo and stigma had diminished enough that we could talk about it.We began to see books written about cancer.We saw [Margaretta]
Alterations in messenger rna encoding atrial natriuretic hormone receptor A and C subtypes during hepatic regeneration
Authors: Tarun B. Patel, Bipin G. Nair, Ekambaram Padmini, Hani M. Rashed, Hui Sun
Journal: Hepatology (1995)

Previously, we demonstrated that, 48 hours after partial hepatectomy, in the regenerating liver the number of both atrial natriuretic hormone (ANF) receptor subtypes, the guanylyl cyclase-linked and ANF-C receptors, is increased twofold. Subsequently, we demonstrated that activation of ANF-C receptors inhibits growth of hepatocytes. Therefore, studies were performed to determine whether, during hepatic regeneration, the increase in ANF receptor subtypes is accompanied by an increase in their respective transcripts. Our data demonstrate that in the normal and regenerating rat liver, the predominant guanylyl cyclase-linked ANF receptor is of the ANF-A subtype. Moreover, messenger RNA (mRNA) encoding the ANF-A and ANF-C receptors are transiently increased after surgery; the levels of mRNA encoding both receptor subtypes remain unchanged in livers of sham-operated animals. ANF-A receptor mRNA is maximally increased 12 hours after partial hepatectomy, whereas the maximal increase in ANF-C receptor mRNA is observed between 0.5 hour and 4 hours after hepatectomy. The increase in ANF-C receptor transcript is accompanied by increased expression of protein, 4 hours after hepatectomy. However, the ANF-C receptor protein is also elevated 48 hours after partial hepatectomy when ANF-C receptor mRNA levels are not different from controls. Likewise, although ANF-A receptors are increased when hepatic levels of mRNA encoding the protein are maximally elevated, the maximal increase in ANF-A receptor protein occurs at times when transcript levels are low and similar to those in sham-operated controls.(ABSTRACT TRUNCATED AT 250 WORDS)
Stimulating the Adoption of Health Information Technology
Authors: David Blumenthal
Journal: New England Journal of Medicine (2009)

The recently enacted stimulus bill — the American Recovery and Reinvestment Act of 2009 (ARRA) — touches almost every aspect of the U.S. economy. Health care is no exception. In fact, the ARRA is historic health care legislation of the type rarely produced by our famously incremental federal government. The law prevents dramatic state cuts in Medicaid, expands funding for preventive health care services and health care research, and helps the unemployed buy health insurance. But perhaps its most profound effect on doctors and patients will result from its unprecedented $19 billion program to promote the adoption and use of . . .