tbuckley/cabot-search huggingface dataset:
Clinical symptoms and immunologic reactivity to bee and wasp stings in beekeepers
Authors: I. T. Annila, E. S. Karjalainen, P. Mörsky, P. A. Kuusisto
Journal: Allergy (1995)

We compared the history of sting reactions with venom skin prick test (SPT) and CAP RAST reactions in beekeepers in order to assess the value of structured questions and symptom backgrounds. The study population consisted of 102 beekeepers, who were 25–75 years of age. Bee and wasp venom SPT was performed with concentrations of 10, 100, and 300 μg/ml. The CAP Phadiatop® test was used in the screening of IgE antibodies against common inhalant allergens. Eorty‐two beekeepers had never experienced large local or systemic reactions after a bee sting. Of the 31 subjects with a history of systemic reactions, 13 had experienced these during the previous year. A significant difference ( P &lt;0.01) between systemic reactors and nonreactors was found in bee venom CAP and SPT (300 μg/ml). However, due to considerable overlap, these tests are unable to discriminate between allergic and nonallergic beekeepers. Both bee venom SPT (300 μg/ml) and CAP tests were positive in 65% of systemic reactors and in 34% of nonreactors ( P =0.008). Venom SPT (300 μg/ml) correlated significantly with CAP for both venoms. No correlation was observed between venom allergy and atopy. Clinically, the most practical concentration for evaluating bee and wasp venom sensitization by SPT proved to be 300 μg/ml.
Development of a novel noninvasive adhesive patch test for the evaluation of pigmented lesions of the skin
Authors: Pedram Gerami, John P. Alsobrook, Tara J. Palmer, Howard S. Robin
Journal: Journal of the American Academy of Dermatology (2014)

BackgroundThe accurate clinical assessment of melanocytic neoplasms is a challenge for clinicians. Currently, obtaining a biopsy specimen and conducting a histologic examination is the standard of care. The incidence of melanoma in white populations is high, resulting in a large number of biopsy specimens.ObjectiveThe objective of this study is to develop a noninvasive genomic method using mRNA to classify pigmented skin lesions as either benign or malignant.MethodsAn adhesive patch method was used to obtain cells from the surface of melanocytic lesions. mRNA was extracted and a genomic signature was formulated in a training set of benign and malignant melanocytic neoplasms and subsequently tested in a validation set.ResultsA 2-gene signature assessing the expression levels of CMIP and LINC00518 was able to differentiate melanomas from nevi in an independent validation set of 42 melanomas and 22 nevi with a sensitivity of 97.6% and specificity of 72.7%.LimitationsLarger and more diverse sets of melanomas and nevi are needed for additional validation of the molecular expression profiling in various subsets of melanocytic neoplasms.ConclusionOur data suggest that mRNA molecular signatures can serve as a highly useful noninvasive method of differentiating melanoma from nevi and decrease the number of unnecessary biopsies. The accurate clinical assessment of melanocytic neoplasms is a challenge for clinicians. Currently, obtaining a biopsy specimen and conducting a histologic examination is the standard of care. The incidence of melanoma in white populations is high, resulting in a large number of biopsy specimens. The objective of this study is to develop a noninvasive genomic method using mRNA to classify pigmented skin lesions as either benign or malignant. An adhesive patch method was used to obtain cells from the surface of melanocytic lesions. mRNA was extracted and a genomic signature was formulated in a training set of benign and malignant melanocytic neoplasms and subsequently tested in a validation set. A 2-gene signature assessing the expression levels of CMIP and LINC00518 was able to differentiate melanomas from nevi in an independent validation set of 42 melanomas and 22 nevi with a sensitivity of 97.6% and specificity of 72.7%. Larger and more diverse sets of melanomas and nevi are needed for additional validation of the molecular expression profiling in various subsets of melanocytic neoplasms. Our data suggest that mRNA molecular signatures can serve as a highly useful noninvasive method of differentiating melanoma from nevi and decrease the number of unnecessary biopsies.
The Effect of Anticoagulants on the Penicillin Therapy and the Pathologic Lesion of Subacute Bacterial Endocarditis
Authors: Walter S. Priest, Jacques M. Smith, Charles J. McGee
Journal: New England Journal of Medicine (1946)

THE nature of the valvular lesions in subacute bacterial endocarditis makes the use of anticoagulants appear a logical procedure in the prevention of fibrin formation. Such agents should thereby keep the vegetative process at a minimum and theoretically render the bacteria more accessible to antibacterial agents. Also, in theory, the frequency of embolism should be reduced.Following the isolation of heparin and the demonstration of its ability to prolong the coagulation time of blood, many workers used this substance alone or in combination with chemotherapeutic and other agents in the treatment of subacute bacterial endocarditis. The results of these efforts . . .
Development of self-reactive germinal center B cells and plasma cells in autoimmune FcγRIIB-deficient mice
Authors: Thomas Tiller, Juliane Kofer, Cornelia Kreschel, Christian E. Busse, Stefan Riebel, Susanne Wickert, Felix Oden, Maria M.M. Mertes, Marc Ehlers, Hedda Wardemann
Journal: The Journal of Experimental Medicine (2010)

Abnormalities in expression levels of the IgG inhibitory Fc gamma receptor IIB (FcγRIIB) are associated with the development of immunoglobulin (Ig) G serum autoantibodies and systemic autoimmunity in mice and humans. We used Ig gene cloning from single isolated B cells to examine the checkpoints that regulate development of autoreactive germinal center (GC) B cells and plasma cells in FcγRIIB-deficient mice. We found that loss of FcγRIIB was associated with an increase in poly- and autoreactive IgG+ GC B cells, including hallmark anti-nuclear antibody–expressing cells that possess characteristic Ig gene features and cells producing kidney-reactive autoantibodies. In the absence of FcγRIIB, autoreactive B cells actively participated in GC reactions and somatic mutations contributed to the generation of highly autoreactive IgG antibodies. In contrast, the frequency of autoreactive IgG+ B cells was much lower in spleen and bone marrow plasma cells, suggesting the existence of an FcγRIIB-independent checkpoint for autoreactivity between the GC and the plasma cell compartment.
Macrophage Infiltration Predicts Restenosis After Coronary Intervention in Patients With Unstable Angina
Authors: Pedro R. Moreno, Vi´ctor H. Bernardi, Julio Lo´pez-Cue´llar, John B. Newell, Charles McMellon, Herman K. Gold, Igor F. Palacios, Valenti´n Fuster, John T. Fallon
Journal: Circulation (1996)

Background Restenosis remains the major limitation of percutaneous coronary revascularization. Macrophages release cytokines, metalloproteinases, and growth factors that may induce smooth muscle cell migration and proliferation. We tested the hypothesis that primary lesions that develop restenosis after coronary atherectomy have more macrophages and smooth muscle cells than primary lesions that do not develop restenosis. Methods and Results Fifty patients with unstable angina were identified. Total and segmental areas were quantified on trichrome-stained sections of coronary atherectomy tissue. Macrophages and smooth muscle cells were identified by immunohistochemical staining. Restenosis, defined as &gt;50% stenosis diameter by quantitative cineangiography, was present in 30 patients. The other 20 patients (&lt;50% stenosis) constitute the “no restenosis” group. The percentages of smooth muscle cell areas were similar in specimens from patients with and without restenosis (57±5% and 52±6%) ( P =NS). However, macrophage-rich areas were larger in plaque tissue from patients with restenosis (20.4±2%) than in tissue from patients without restenosis (9.3±2%) ( P =.0007). Multiple stepwise logistic regression analysis identified macrophages as the only independent predictor for restenosis ( P =.006). Conclusions Macrophages are increased in coronary atherectomy tissue from primary lesions that develop restenosis, suggesting a possible role for macrophages in the restenotic process after percutaneous coronary intervention.
BDELLONYSSUS BACOTI AS A CAUSAL AGENT OF CUTANEOUS DISEASE.
Authors: E. A. FAIRBURN, W. FRAIN-BELL
Journal: British Journal of Dermatology (1956)

Journal Article BDELLONYSSUS BACOTI AS A CAUSAL AGENT OF CUTANEOUS DISEASE. Get access E. A. FAIRBURN, M.D., M.R.C.P., E. A. FAIRBURN, M.D., M.R.C.P. Clinical Assistant Search for other works by this author on: Oxford Academic Google Scholar W. FRAIN‐BELL, M.D., M.R.C.P.(Ed.). W. FRAIN‐BELL, M.D., M.R.C.P.(Ed.). Senior Registrar, St. John's Hospital for Diseases of the Skin, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 68, Issue 11, 1 November 1956, Pages 350–354, https://doi.org/10.1111/j.1365-2133.1956.tb12765.x Published: 01 November 1956
The Stimulatory Potency of T Cell Antigens Is Influenced by the Formation of the Immunological Synapse
Authors: Sašo Čemerski, Jayajit Das, Jason Locasale, Phoebe Arnold, Emanuele Giurisato, Mary A. Markiewicz, Daved Fremont, Paul M. Allen, Arup K. Chakraborty, Andrey S. Shaw
Journal: Immunity (2007)
THE NECESSARY PEROXIDE OF HYDROGEN.Read in the Section of Surgery and Anatomy, at the Forty-first Annual Meeting of the American Medical Association, held at Nashville, Tenn., May, 1890.
Authors: ROBERT T. MORRIS
Journal: JAMA (1890)

Stop suppuration! That is the duty that is imposed upon us when we fail to prevent suppuration. As the ferret hunts the rat, so does peroxide of hydrogen follow pus to its narrowest hiding place, and the pyogenic and other microörganisms are as dead as the rat that the ferret catches, when the peroxide is through with them. Peroxide of hydrogen H<sub>2</sub>O<sub>2</sub>in the strong 15-volume solution is almost as harmless as water, and yet, according to the testimony of Giffbrd, it kills anthrax spores in a few minutes. For preventing suppuration we have bichloride of mercury, hydronaphthol, carbolic acid, and many other antiseptics, but for stopping it abruptly and for sterilizing a suppurating wound we have only one antiseptic that is generally efficient so far as I know, and that is the strong peroxide of hydrogen. Therefore I have qualified it, not as "good," not as "useful," but as
Angela's Ashes: A Memoir
Authors: Frances R. Frankenburg
Journal: JAMA (1997)

This memoir, the story of Frank McCourt's Limerick childhood in the 1930s and 1940s, won both the National Book Critics Circle Award and the Pulitzer Prize. As depicted, the innocence, good humor, and love of language and family rising above the squalor of the author's childhood contribute to the book's success. McCourt's vivid recall of the health problems that affected him and those around him will interest physicians, especially in the areas of public health and the history of medicine. The two tragedies of the McCourt family were the father's alcoholism and childhood deaths. Frank's father, Malachy, had been dropped on his head as a child and was supposed, at least by the family of Angela, Frank's mother, never to have been quite right afterwards. But Malachy's main problem was his alcoholism. Malachy was not abusive when he was drunk—at least, not directly. But he drank the family into semistarvation
EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa
Authors: Mai M Abd El-Aziz, Isabel Barragan, Ciara A O'Driscoll, Leo Goodstadt, Elena Prigmore, Salud Borrego, Marcela Mena, Juan I Pieras, Mohamed F El-Ashry, Leen Abu Safieh, Amna Shah, Michael E Cheetham, Nigel P Carter, Christina Chakarova, Chris P Ponting, Shomi S Bhattacharya, Guillermo Antinolo
Journal: Nature Genetics (2008)
Rhesus monkey lipoprotein(a) binds to lysine Sepharose and U937 monocytoid cells less efficiently than human lipoprotein(a). Evidence for the dominant role of kringle 4(37).
Authors: A M Scanu, L A Miles, G M Fless, D Pfaffinger, J Eisenbart, E Jackson, J L Hoover-Plow, T Brunck, E F Plow
Journal: Journal of Clinical Investigation (1993)

Rhesus lipoprotein(a) (Lp[a]) binds less efficiently than human Lp(a) to lysine-Sepharose and to cultured U937 cells. Studies using elastase-derived plasminogen fragments indicated that neither kringle 5 nor the protease domain of Lp(a) are required in these interactions pointing at an involvement of the K4 region. Comparative structural analyses of both the human and simian apo(a) K4 domain, together with molecular modeling studies, supported the conclusion that K4(37) plays a dominant role in the lysine binding function of apo(a) and that the presence of arginine 72 rather than tryptophan in this kringle can account for the functional deficiency observed with rhesus Lp(a). These in vitro results suggest that rhesus Lp(a) may be less thrombogenic than human Lp(a).
Ozone exposure has both a priming effect on allergen-induced responses and an intrinsic inflammatory action in the nasal airways of perennially allergic asthmatics.
Authors: D B Peden, R W Setzer, R B Devlin
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Ozone may play a significant role in the exacerbation of airway disease in asthmatics, either by priming the airway mucosa such that cellular responses to allergen are enhanced or by exerting an intrinsic effect on airway inflammation. Previous investigations of nonasthmatic subjects revealed that ozone induces both nasal and bronchial inflammation, suggesting that nasal responses to ozone may be used as a surrogate marker for the effect of this pollutant on bronchial mucosal inflammation. In this study, the effect of exposure to 0.4 ppm ozone on nasal inflammation in 11 allergic asthmatics sensitive to Dermatophygoides farinae was examined. This study was designed such that the effect of ozone exposure on the late-phase reaction to allergen was emphasized, using eosinophil influx and changes in eosinophil cationic protein as principal endpoints. By employing a "split-nose" design, in which allergen was applied to only one side of the nose while saline was applied to the contralateral side, both the effect of ozone on nasal inflammation due to allergen challenge as well as its direct action on non-allergen-challenged nasal tissues was examined. The results reported herein indicate that ozone exposure has both a priming effect on allergen-induced responses as well as an intrinsic inflammatory action in the nasal airways of perennially allergic asthmatics.
HLA-DRB1*15:01 allele protects from asthma susceptibility
Authors: María Pino-Yanes, Almudena Corrales, Marialbert Acosta-Herrera, Eva Pérez-Rodríguez, José Cumplido, Paloma Campo, Amalia Barreto-Luis, Florentino Sánchez-García, Tobías Felipe, Inmaculada Sánchez-Machín, Inés Quintela, José Carlos García-Robaina, Jesús Villar, Miguel Blanca, Angel Carracedo, Teresa Carrillo, Carlos Flores
Journal: Journal of Allergy and Clinical Immunology (2014)
Intra-atrial reentry as a mechanism for atrial flutter induced by acetylcholine and rapid pacing in the dog.
Authors: M A Allessie, W J Lammers, I M Bonke, J Hollen
Journal: Circulation (1984)

In the isolated blood-perfused canine heart we produced episodes of rapid atrial flutter by continuous infusion of acetylcholine and rapid pacing. The spread of excitation during atrial flutter was mapped with the aid of two endocavitary mapping electrodes containing 960 leads and recording from 192 different sites simultaneously. The flutter maps clearly showed that intra-atrial reentry was the mechanism responsible for the arrhythmia. However, the localization and size of the intra-atrial circuits differed from case to case even in the same heart. The orifices of the venae cavae or the atrioventricular ring did not serve as a central anatomic obstacle for circus movement. We also failed to identify a special role of the internodal pathways in the formation of the loop. Instead, the intra-atrial circuits could be found everywhere, provided sufficient atrial mass was available to accommodate the circuit. The diameter of the circuits varied between 1.5 and 3 cm at a cycle length between 65 and 155 msec. The average conduction velocity of the circulating impulse varied between 60 and 80 cm/sec. Spontaneous termination of atrial flutter frequently occurred and was based on local conduction block in a narrow part of the circuit. Another interesting aspect of these studies is the finding that during continuous circus movement of the impulse, the amount of myocardium that is activated may vary considerably. This marked periodicity in excited tissue mass during atrial flutter could adequately explain the continuously undulating baseline or typical sawtoothlike F waves as seen in the surface electrocardiogram during atrial flutter.
Temporomandibular joint in adult rheumatoid arthritis. A comparative evaluation of 100 cases.
Authors: A S Franks
Journal: Annals of the Rheumatic Diseases (1969)

As emphasized by Uotila (1964), medical interest in the stomatognathic system of patients with rheumatoid arthritis has been mainly concerned with the theories of focal infection.In recent years these concepts have become less commonly accepted and the interest accordingly reduced.However, the temporomandibular joints may be considered amongst the more important of the body and a practical clinical consideration of their reaction to systemic disease is an obvious requirement.The knowledge that rheumatoid arthritis affects the temporomandibular joint has been on record for a number of years, but the reported incidence of manifestations in this joint vary greatly in the literature (Table I).The majority of previous studies have dealt with relatively small numbers of patients.
Scientists Apply Gene Therapy to Treat Blinding Eye Diseases in Animals
Authors: Tracy Hampton
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endothelin-1 receptor antagonist: Effects on endothelin- and cyclosporine-treated mesangial cells
Authors: Michio Takeda, Matthew D. Breyer, Thomas D. Noland, Toshio Homma, Richard L. Hoover, Tadashi Inagami, Valentina Kon, Deidriene M. Fredin, Samuel E. Hellings
Journal: Kidney International (1992)
Microbiopsy metabolite and paired flow analysis: a new rapid procedure for homogenisation, extraction and analysis of high energy phosphates and other intermediates without any errors from tissue loss
Authors: D. J HEARSE
Journal: Cardiovascular Research (1984)

A new procedure is described which allows for the rapid homogenisation, extraction and analysis of the metabolite content of microbiopsy samples (milligram quantities) while completely overcoming the major errors arising as the consequence of the substantial and variable tissue loss associated with conventional procedures. In addition to allowing more accurate and faster analysis of much smaller quantities of tissue the procedure also allows for the coincident paired measurement of flow (radioactive microspheres) in each biopsy. An example of the application of the method to the measurement of flow and high energy phosphate content in multiple microbiopsy samples from normal and ischaemic canine myocardium is provided.
Metabolic Syndrome in American Indians
Authors: Helaine E. Resnick
Journal: Diabetes Care (2002)

The National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III [ATP III]) recently proposed a formal definition of the metabolic (insulin resistance) syndrome (1). For the purposes of ATP III, metabolic syndrome is present when ≥3 of the following determinations are present: waist circumference >102 or >88 cm in men and women, respectively; triglycerides ≥150 mg/dl; HDL cholesterol <40 or <50 mg/dl in men and women, respectively; blood pressure ≥130/≥85 mmHg; and fasting glucose ≥110 mg/dl.

Data from the Third National Health and Nutrition Examination Survey (NHANES III) show that among U.S. adults ≥20 years of age, metabolic …
Treatment for Depression Following the 1996 National Depression Screening Day
Authors: Shelly F. Greenfield, Joelle Meszler Reizes, Larry R. Muenz, Barbara Kopans, Rene C. Kozloff, Douglas G. Jacobs
Journal: American Journal of Psychiatry (2000)

OBJECTIVE: Characteristics of the subsequent treatment received by people who screened positive for depression in the 1996 National Depression Screening Day were investigated. METHOD: A follow-up telephone survey was completed by 1,502 randomly selected participants from 2,800 sites. RESULTS: Of 927 people for whom additional evaluation was recommended, 602 (64.9%) obtained evaluations and 503 (83.6%) received treatment. Of these 503, 260 (51.7%) received psychotherapy and medication, 130 (25.8%) received medication only, and 93 (18.5%) received psychotherapy only. Compared with people without health or mental health insurance, individuals with health insurance (66.7% versus 57.5%) and mental health insurance (74.6% versus 55.3%) were more likely to comply with the recommendation to obtain follow-up evaluation. CONCLUSIONS: One-half of the people treated for depression received a combination of psychotherapy and medication. Lack of insurance was associated with not following the recommendation to obtain further evaluation and treatment.
Small bowel biopsy for malabsorption: comparison of the diagnostic adequacy of endoscopic forceps and capsule biopsy specimens.
Authors: A S Mee, M Burke, A G Vallon, J Newman, P B Cotton
Journal: BMJ (1985)

Biopsy specimens of the small bowel were obtained from 40 patients suspected of having malabsorption. Four different techniques were used at a single session--namely, endoscopic biopsy of the descending duodenum using paediatric and standard size forceps and suction capsule biopsy of the descending duodenum and the proximal jejunum. Specimens were compared for size, adequacy, and ability to confirm or exclude mucosal abnormality. Fourteen patients had villous atrophy. In all patients four biopsy specimens were obtained with paediatric endoscopic forceps and four with standard endoscopic forceps. No capsule biopsy specimen was retrieved from the duodenum in three patients and from the jejunum in five patients. Specimens were considered to be adequate in 36 patients when paediatric forceps were used, in 39 when standard forceps were used, in 28 on duodenal capsule biopsy, and in 32 on jejunal capsule biopsy. This study indicates that the most reliable method for diagnosing or excluding villous atrophy is endoscopic forceps biopsy of the descending duodenum, provided that at least four specimens are obtained with standard size forceps.