Mitomycin and Interstitial Pneumonitis
Authors: A. THOMAS ANDREWS
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 January 1979Mitomycin and Interstitial PneumonitisA. THOMAS ANDREWS, M.D., HERBERT S. BOWMAN, M.D., SHASHIKANT B. PATEL, M.D., WILLIAM M. ANDERSON, M.D.A. THOMAS ANDREWS, M.D.Search for more papers by this author, HERBERT S. BOWMAN, M.D.Search for more papers by this author, SHASHIKANT B. PATEL, M.D.Search for more papers by this author, WILLIAM M. ANDERSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-127_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Orwoll and others (1) have reported in the September issue on the association of mitomycin with interstitial pneumonia. In the past 2 years we have seen two patients who died with unexplained severe interstitial pneumonitis after receiving mitomycin chemotherapy.The first case was that of a 53-year-old man with adenocarcinoma of the pancreas who received weekly mitomycin, 5-fluorouracil, and cytosine arabinoside during an 18-week period for a total mitomycin dose of 50 mg. He developed progressive dyspnea leading to death within 3 weeks after a short preterminal period of progressive dyspnea. At autopsy, alveolar septal thickening and...References1. ORWOLLKIESSLINGPATTERSON EPJ: Interstitial pneumonia from mitomycin. Ann Intern Med 89:352-355, 1978 LinkGoogle Scholar2. COLEMYERSKLATUSKY STA: Pulmonary disease with chlorambucil therapy. Cancer 41:455-459, 1978 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Harrisburg Hospital South Front Street; Harrisburg, PA 17101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThoracic complications in patients undergoing intraperitoneal heated chemotherapy with mitomycin following cytoreductive surgeryPulmonary Effects of Cytotoxic Agents Other Than BleomycinThe Histopathology of Pulmonary Reactions to DrugsPulmonary Toxicity of Cytotoxic and Immunosuppressive Agents: A ReviewProspective study on the dose relationship of mitomycin C–induced interstitial pneumonitisMitomycin C-induced hemolytic uremic syndrome. Six casereports and review of the literature on renal, pulmonary and cardiac side effects of the drugPulmonary toxicity induced by mitomycin C is highly responsive to glucocorticoidsCombination chemotherapy with mitomycin-C, cisplatin, and vinblastine in the treatment of non-small-cell lung cancerCombination chemotherapy with mitomycin C, methotrexate, cisplatin, and vinblastine in the treatment of non-small cell lung cancerPulmonary veno-occlusive disease after chemotherapyDrug-Induced Interstitial Lung DiseasesInterstitial pneumonitis associated with mitomycin C and DTIC: A case reportCytotoxic drug-induced pulmonary disease: Update 1980Cytostatic and immunosuppressive drugs 1 January 1979Volume 90, Issue 1Page: 127-127KeywordsAdenocarcinomaAutopsyChemotherapyCytosineDyspneaInterstitial lung diseasesPancreas Issue Published: 1 January 1979 PDF DownloadLoading ...