tbuckley/cabot-search huggingface dataset:
Abstract C62: Cancer cell dependence on unsaturated fatty acids implicates stearoyl-coA desaturase as a target for cancer therapy
Authors: Urvashi V. Roongta, R. Michael Lawrence, Tai W. Wong, Brent A. Rupnow, Jonathan G. Pabalan, Xinyu Wang, Rolf-Peter Ryseck, Joseph Fargnoli, Benjamin J. Henley, Wen-Pin Yang, Jun Zhu, Malavi T. Madireddi
Journal: Cancer Research (2011)

Abstract Emerging literature suggests that metabolic pathways play an important role in the maintenance and progression of human cancers. In particular, recent studies have implicated lipid biosynthesis and desaturation as a requirement for tumor cell survival. In the studies reported here, we aimed to understand whether tumor cells require the activity of either human isoform of stearoyl-CoA-desaturase (SCD1 or SCD5) for survival. Inhibition of SCD1 by siRNA or a small molecule antagonist results in strong induction of apoptosis and growth inhibition when tumor cells are cultured in reduced (2%) serum conditions but has little impact on cells cultured in 10% serum. Depletion of SCD5 had minimal effects on cell growth or apoptosis. Consistent with the observed dependence on SCD1 but not SCD5, levels of SCD1 protein increased in response to decreasing serum levels. Both induction of SCD1 protein and sensitivity to growth inhibition by SCD1 inhibition could be reversed by supplementing growth media with oleic acid, a product of the enzymatic reaction catalyzed by SCD1. Transcription profiling of cells treated with an SCD inhibitor revealed strong induction of markers of endoplasmic reticulum stress. Underscoring its importance in cancer, SCD1 protein was found to be highly expressed in a large percentage of human cancer specimens. SCD inhibition resulted in tumor growth delay in a human gastric cancer xenograft model. Altogether, these results suggest that desaturated fatty acids are required for tumor cell survival and that SCD may represent a viable target for the development of novel agents for cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr C62.
Ovarian hyperstimulation from ectopic hypersecretion of follicle stimulating hormone
Authors: Alexander D Miras, Julianne T Mogford, John Wright, Nigel N Mendoza, Paraskevi Xekouki, Amish Lakhani, Natalia S Pellegata, Costantine A Stratakis, Federico Roncaroli, David Russell-Jones
Journal: The Lancet (2015)
PYELITIS, AN IMPORTANT FACTOR IN THE PATHOGENESIS OF RETROGRADE PYELONEPHRITIS
Authors: Burton R. Andersen, George Gee Jackson
Journal: The Journal of Experimental Medicine (1961)

Pyelitis with acute and chronic pyelonephritis and also primary chronic pyelitis were easily initiated in female rats by a single non-traumatic retrograde infusion of bacteria into the urinary tract. The virulence of the bacterial species and the time of observation were related to the type and extent of lesions, but pyelitis regardless of the virulence appeared to be an important factor. The apex and fornix of the renal pelvic lumen were anatomic sites of persistent pyelitis which permitted local proliferation of bacteria for long periods. Cortical and medullary lesions were anatomically related to these areas of underlying pyelitis. Spread of infection followed a pattern of contiguity rather than ascending tubular infection. The experimental model has many of the features of chronic urinary infections in man and suggests that pyelitis is an important factor in the pathogenesis of chronic pyelonephritis initiated by retrograde infection.
Abstract 492: Identification of a novel complex MUC1/CIN85 involved in invasion and migration of breast cancer cells
Authors: Sandra Cascio, Olivera Finn
Journal: Cancer Research (2012)

Abstract MUC1 is a transmembrane glycoprotein abnormally expressed in human adenocarcinoma. The extracellular domain of MUC1 contains a variable number of tandem repeats 20aa in length (VNTR region) which is fully glycosylated in normal epithelia and underglycosylated in tumor cells. We recently demonstrated that tumor form of MUC1 increases the accessibility of the VNTR peptide backbone to other proteins thus affecting protein-protein interactions and intracellular signaling. By using MALDI-TOF, we identified CIN85 as one of the proteins that bind the extracellular domain of MUC1. CIN85 is an adaptor protein involved in multiple cellular processes including signal transduction, vesicle-mediated transport, cytoskeleton remodelling, invasion and migration of cancer cells. Structurally, CIN85 contains three SH3 domains, a proline-rich region and a C-terminal coiled-coil region. The SH3 domain of CIN85 recognizes a specific sequence PXXAP that corresponds to the PDTRP sequence in the 20 amino acid tandem repeat in the MUC1 VNTR. Co-immunoprecipitation assay and confocal immunofluorescence confirmed that MUC1 and CIN85 co-localize in MUC1-transfected RMA (mouse T cell lymphoma) and IG10 (mouse ovarian carcinoma) cells and in human breast cancer cells MDA-MB-231 and MDA-MB-435 that express endogenous MUC1 and CIN85. Subcellular protein fractionation revealed that CIN85 and MUC1 co-localize mainly at plasma membrane but also in the cytosol. To better understand the function of CIN85/ MUC1 complex we analyzed their expression by immunohistochemistry and confocal immunofluorescence in human tissue microarray (TMA) composed of 31 breast cancer samples and 5 adjacent normal tissue. Hypoglycosylated MUC1 and CIN85 are over-expressed and co-localize in early and advanced clinical stage of breast cancer. Interestingly, CIN85 and MUC1 were localized to invadopodia-like structures suggesting a potential role in cancer cell invasion. siRNA-mediated silencing of CIN85 and/or MUC1 revealed that MUC1 enhances CIN85-dependent cell invasion and migration of breast cancer cells. In contrast, ectopic expression of MUC1 reduces the motility induced by CIN85. In conclusion, our finding suggest that the novel complex CIN85/MUC1 play a critical role in invadopodia formation and have control on invasive and metastatic potential of breast cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 492. doi:1538-7445.AM2012-492
Epidemic Bronchiolitis and Pneumonitis Related to Respiratory Syncytial Virus
Authors: John M. Adams
Journal: JAMA (1961)

THIS PRELIMINARY report describes an epidemic of acute respiratory disease in infants and children occurring during January, February, and March, 1961, and most probably due to respiratory syncytial (RS) virus. The epidemic is characterized by its predilection for young infants, by low-grade fever, cough, dyspnea, and cyanosis with signs of bronchiolar obstruction and pneumonitis. It is quite similar to an epidemic of primary virus pneumonitis with cytoplasmic inclusion bodies observed by Dr. Adams in January, February, and March, 1937, and first reported in 1941.<sup>1,2</sup> In the present epidemic, a viral agent has been isolated in HeLa cells and primary monkey kidney cells directly from throat washings. Eight strains of viruses have been isolated from 12 different patients. Cytopathic changes, characterized by a syncytium, with giant cell formation and distinctive cytoplasmic inclusion bodies, have been demonstrated. No intranuclear inclusions were observed. These changes in cell culture preparations are illustrated in
DIAGNOSIS OF TUBERCULAR MENINGITIS BY TUBERCULIN.
Authors: CHARLES DENISON
Journal: JAMA (1893)

Of eight cases of confirmative diagnosis of tuberculosis, which I have thus far made with tuberculin (Koch's), where there was either no bacilli found in sputum or no sputum to examine, the following I wish to report as possibly the first diagnosis of chronic tubercular bassilar meningitis made by that means. April 16, last, I was called to North Denver to see Dr. O. B. Gould of Newport, Vt., a physician who had evidently been a very hard worker, age 38. Family history peculiar and showing marked tubercular tendency; mother died of consumption and father supposed to have died of meningitis. Five sisters out of seven children died of consumption; one of these sisters had great pain in back of head, just like this patient, six years before her death, which pain had eventuated in a tubercular cough. Her son had severe headaches and died at the age of seventeen
Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study
Authors: Manu L. N. G. Malbrain, Davide Chiumello, Paolo Pelosi, Alexander Wilmer, Nicola Brienza, Vincenzo Malcangi, David Bihari, Richard Innes, Jonathan Cohen, Pierre Singer, Andre Japiassu, Elizabeth Kurtop, Bart L. De Keulenaer, Ronny Daelemans, Monica Del Turco, P. Cosimini, Marco Ranieri, Luc Jacquet, Pierre-Fran�ois Laterre, Luciano Gattinoni
Journal: Intensive Care Medicine (2004)
694 MDRD CREATININE CLEARANCE IS NOT ALTERED IN HIV-HBV CO-INFECTED PATIENTS WITH A NORMAL RENAL FUNCTION AND TREATED WITH TENOFOVIR (TDF)
Authors: K. Lacombe, A. Boyd, P. Bonnard, J.M. Molina, P. Miailhes, J.L. Meynard, L. Taulera, A. Rachline, L. Cotte, A. Trylesinski, P.M. Girard
Journal: Journal of Hepatology (2008)
Detection of Lacrimal Gland Infiltration on Routine Bone Scintigraphy
Authors: ELISSA L. KRAMER, JOSEPH J. SANGER, DANIEL D. BENJAMIN, SERAFIN TIU
Journal: Clinical Nuclear Medicine (1983)

REICHTER, RUSSELL E. M.D.1; PARK, HEE-MYUNG M.D.1; HALL, DAVID M.D.1,* Author Information
Serum Cholesterol Values in Patients Treated Surgically for Atherosclerosis
Authors: H. Edward Garrett, Evan C. Horning, Billy G. Creech, Michael De Bakey
Journal: JAMA (1964)

An analysis of cholesterol values by usual hospital laboratory methods in 1,700 patients with atherosclerotic disease revealed no definite correlation between serum cholesterol levels and the nature and extent of atherosclerotic disease. Eight out of ten patients had cholesterol values below 300 mg/100 ml, the upper limits of normal for the procedure employed. Associated diseases such as diabetes mellitus and arteriosclerotic heart disease, age, and anatomical location and extent of atherosclerotic disease did not significantly alter the distribution of cholesterol values. Although an elevated cholesterol level may be a factor in abnormal lipid metabolism and associated atherosclerotic disease, the majority of patients in this group had serum cholesterol values within the accepted normal range for Americans.
School Health Education
Authors: Lawrence W. Green, Donald C. Iverson
Journal: Annual Review of Public Health (1982)

In this review we assess the recent developments in research and practice pertaining to health education in schools. We begin by defining school health education within the broader framework of community health education and promotion. The shifting priorities purposes and assumptions of school health education are traced and attributed. They lead to a new generation of problems and methods that call for a concentration of research on ways to combine the classroom contributions of health education with the broader organizational economic and environmental supports that will predispose enable and reinforce behavior conducive to health.  (excerpt)
UK judges reverse decision on cloned embryos
Authors: C. Dyer
Journal: BMJ (2002)

A High Court ruling that threatened to wreck UK government controls over cloning for research was overturned by the court of appeal last week.

Three appeal court judges, headed by the master of the rolls, Lord Phillips, reversed a ruling last November by Mr Justice Crane that the Human Fertilisation and Embryology Act 1990 did not cover embryos created by cloning, but only those created by fertilisation.

Cloning was still in the future when the act was passed and the statute defines an …
Relation of −55CT polymorphism of uncoupling protein 3 gene with fat mass and insulin resistance in morbidly obese patients
Authors: Daniel Antonio de Luis Roman, Rocio Aller, Olatz Izaola Jauregui, Manuel Gonzalez Sagrado, Rosa Conde Vicente, Beatriz de la Fuente Salvador, Enrique Romero Bobillo
Journal: Metabolism (2009)
Purtscher's-like Retinopathy after Childbirth
Authors: Barbara A. Blodi, Mark W. Johnson, J. Donald M. Gass, Stuart L. Fine, Leonard M. Joffe
Journal: Ophthalmology (1990)

Severe bilateral visual loss attributable to multiple retinal arteriolar occlusions occurred in four young women within 24 hours after childbirth. In two patients, labor was complicated by preeclampsia requiring cesarean section. One patient was suffering from pancreatitis. None had connective tissue disease or antecedent trauma. Ophthalmoscopy and fluorescein angiography revealed evidence of multiple superficial peripapillary and macular patches of ischemic retinal whitening simulating Purtscher's retinopathy. By 8 weeks, the white patches were resolving in all eyes and visual acuity had significantly improved in three of the four patients. The pathogenesis of this disorder is unknown but may involve arteriolar obstruction by complement-induced leukoemboli formed during parturition.
Stokes-Adams Attacks with Simultaneous Auricular and Ventricular Standstill
Authors: NAIP TUNA, JOHN W. SCOTT
Journal: Circulation (1954)

This is a report of a case of Stokes-Adams seizures in a patient with partial auriculoventricular block. Simultaneous auricular and ventricular standstill in about half the seizures of which we have electrocardiographic record, and complete relief after atropine, leads us to think the seizures were due to vagal effect.
Progression of Asthma Measured by Lung Function in the Childhood Asthma Management Program
Authors: Ronina A. Covar, Joseph D. Spahn, James R. Murphy, Stanley J. Szefler
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

From the Childhood Asthma Management Program cohort, which was randomly assigned to receive budesonide, nedocromil, or placebo for 4–6 years, we determined the prevalence of and factors associated with at least 1% per year loss in postbronchodilator FEV1% predicted. Participants who had a significant reduction in postbronchodilator FEV1% predicted (SRP), comprised 25.7% of the cohort (n = 990). Using logistic regression, predictors of SRP at baseline were younger age (p = 0.0005), male sex (p < 0.0001), clinic (p = 0.02), and higher postbronchodilator FEV1% predicted (p = 0.02). Examination of the SRPs indicated that the effect of baseline lung function was such that the higher the lung function, the less steep the reduction in postbronchodilator FEV1% predicted (p < 0.0001). A similar proportion of SRPs was found in each treatment group. Among the SRPs, the rate of reduction in postbronchodilator FEV1% predicted was similar in all treatment groups. At a single site where biomarker assessment was performed, SRPs also had more prominent eosinophilic inflammation during the washout period. The course and mechanisms of lung function reduction or slow lung growth velocity in children with asthma must be defined.
How Many Doctors Do We Need?
Authors: John K. Iglehart
Journal: JAMA (1985)

LEADERS of American medicine are divided over whether the nation faces a future physician surplus as a consequence of federal policies that encouraged medical schools and teaching hospitals to increase their production of new physicians. When the subject of a possible surplus is discussed, as it was recently at the tenth annual Private Sector Conference, sponsored by Duke University, Durham, NC, approaches for dealing with the question revolve around calls for a sharp reduction in the number of foreign medical graduates (FMGs) and upgrading the quality of training and the rigor of monitoring physician performance, thus easing out of medicine marginal practitioners. Most conference participants viewed turning to government for solutions as a last resort, but one that practicing physicians would likely increasingly encourage at the state level in their search for relief from the enlarging pool of professional competitors. This year's conference, organized as it is annually by William
Descriptions of therapeutic arthrocenthesis and of synovial fluid in a Nahuatl text from prehispanic Mexico.
Authors: D Alarcon-Segovia
Journal: Annals of the Rheumatic Diseases (1980)

Paracelsus is considered to have been the first to record the viscid quality of the synovial fluid. However, his contemporary Bernardino de Sahagún, a Franciscan friar who came to Mexico shortly after the Spanish conquest, obtained from elderly Aztec Indians who spoke only Nahuatl the descriptions of therapeutic arthrocentesis and of the viscid nature of the synovial fluid. They compared the fluid from the knee joint to the viscid fluid from the leaves of the nopal cactus (Opuntia sp.). We here record their description and confirm the accuracy of their comparison.
Intrauterine sensitization of allergen-specific IgE analyzed by a highly sensitive new allergen microarray
Authors: Norio Kamemura, Hitomi Tada, Naoki Shimojo, Yoshinori Morita, Yoichi Kohno, Takao Ichioka, Koichi Suzuki, Kenji Kubota, Mineyoshi Hiyoshi, Hiroshi Kido
Journal: Journal of Allergy and Clinical Immunology (2012)
CD23 Regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18
Authors: Sybille Lecoanet-Henchoz, Jean-Francois Gauchat, Jean-Pierre Aubry, Pierre Graber, Paul Life, Nathalie Paul-Eugene, Bernard Ferrua, Angel Luis Corbi, Bernard Dugas, Christine Plater-Zyberk, Jean-Yves Bonnefoy
Journal: Immunity (1995)
The use of external mesh reinforcement to reduce intimal hyperplasia and preserve the structure of human saphenous veins
Authors: Alban Longchamp, Florian Alonso, Céline Dubuis, Florent Allagnat, Xavier Berard, Paolo Meda, François Saucy, Jean-Marc Corpataux, None Sébastien Déglise, Jacques-Antoine Haefliger
Journal: Biomaterials (2014)
Thirdhand Smoke: Studies Multiply, Catchy Name Raises Awareness
Authors: Rabiya S. Tuma
Journal: JNCI Journal of the National Cancer Institute (2010)

H ealth agencies have warned of the danger of secondhand smoke for decades. Now a small but growing number of scientists are testing the possible health effects associated with the residue that cigarette smoke deposits on furniture, clothing, and other surfaces, a substance some are calling “thirdhand smoke.” The magnitude of the problem, the amount of attention and resources it warrants, and even the defi nition of the term itself remain a matter of debate, however. Some tobacco control experts think any effect from thirdhand smoke will be relatively limited and that the new term has driven recent interest more than scientifi c discoveries have. Despite that skepticism, at least one tobacco research agency has decided that thirdhand smoke and its potential effect on public health warrants greater scrutiny and announced a new funding initiative to support basic research on the potential hazards. Last year, Jonathan Winickoff, M.D., associate professor of pediatrics at Massachusetts General Hospital in Boston, and colleagues made headlines when they published a report on public attitudes about smoke residue, calling it “thirdhand smoke.” On the basis of a nationwide telephone survey, Winickoff’s team reported that individuals who thought thirdhand smoke was dangerous were more likely to ban smoking entirely from their homes than were individuals who did not perceive a health risk from smoke residue. The study attracted widespread media attention. Many of the news stories, though, focused not on the survey results but on the phrase “thirdhand smoke,” reporting that this was a new health hazard associated with cigarettes.
Points from Letters: Dust Mites in Hospitals
Authors: J. B. Cookson
Journal: BMJ (1975)

Ketoprofen, one of the many propionic acid derivatives flooding the market, is the subject of another substantial promotional programme only 12 months after the first. . ..Pharmaceutical companies, it seems, are playing into the hands of "Bennery" witlh such blatant "burning" of profits.. The public can hardly be expected to support the call for more money for the N.H.S. when it seems the medical profession is doing little to discourage such wasteful practices....
Anticoagulation uptake remains poor in high risk patients
Authors: C. Cowan, M. Fay, K. Griffith, D. Jenkinson
Journal: BMJ (2011)

Olesen and colleagues validate the predictive value of the CHA2DS2VASc score among patients admitted to hospital with atrial fibrillation (AF), showing its superiority to the traditional CHADS2 score in identifying patients at low risk of stroke.1 However, even among patients with identified atrial fibrillation and identifiable risk factors, the uptake of anticoagulation …
The Score on Medicare Reform — Minus the Hype and Hyperbole
Authors: G R Wilensky
Journal: New England Journal of Medicine (1995)

With charges and countercharges about impending Medicare reforms at a feverish pitch, the substantive issues in the debate have become increasingly obscured. This highly charged climate has left most Americans confused about the consequences of the proposed changes and needlessly fearful about the future of a program that, by most measures, has been immensely popular with older adults and their families.With Medicare's trust fund facing insolvency by the year 2002 and pressure on the federal budget from the costs of Medicare Part B, which covers physicians' and outpatient services and is primarily funded directly from general revenue, the Republican . . .
Attacks Our Exchanges.
Authors: None Pro-Cohen
Journal: JAMA (1894)

Philadelphia, March 21, 1891. <h3>To the Editor:</h3> —I write to endorse Dr. Cohen and the Code, but I go further: I would not receive or quote from any journal that publishes advertisements of the character condemned by Dr. Cohen. My proposition is that noAssociationmoney shall be paid for printing a journal to be given in exchange to any journal that prostitutes itself by publishing the vile advertisements in question. Let us fight this thing to the finish.
Sulphapyridine and Pneumococcal Infections
Authors: H. L. Marriott
Journal: BMJ (1939)

The purpose of this paper is tc facts relating to sulphapyridine, with its use in combating 1 Although only eighteen months Whitby' first published his dis sulphapyridine, yet in this short papers concerning it have bi countries.It is now establisl is a most effective agent again, cocci of all types.'-6In its aci coccus it represents an outstt for it is superior to specific anti at present by any other sulphc chief evidence for these statemei the case series 7-26 summarized TABLE I.
The McDowell Biography.
Authors: S. L. Henry
Journal: JAMA (1895)

New Orleans, Oct. 4, 1895. <h3>To the Editor:</h3> —Some time ago, over one year, a lady came to my office soliciting subscriptions to the biography of Ephraim McDowell, M.D., claiming among other things, that she was a distant relative of the Doctor. I find my receipt for the price of said book, but no book yet. I do not believe the Doctor would approve of such slow treatment or action. As I have not her address, and I noticed some time since you had, would you kindly send this to her, or to those in charge of publication, and oblige,