tbuckley/cabot-search huggingface dataset:
Treatment of candidal urinary tract infection with nifuratel.
Authors: R N Gruneberg, A Leakey
Journal: BMJ (1976)

Three patients with candidal urinary tract infections were successfully treated with oral nifuratel, a nitrofuran antimicrobial agent active against yeast and Trichomonas as well as urinary bacterial pathogens. The recommended dose is 400 mg thrice daily for a week. No side effects that could be attributed to the treatment were noted. Minimum ibhibitory concentration determinations for nifuratel against Candida strains of five species showed that 48 out of 59 organisms were inhibited by 50 mg/1 or less, the three strains of Candida species eliminated from our treated patients having MICs of nifuratel in the range of 10-50 mg/1.
ENZYMATIC ACTIVITY OF DPIV AND RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) PROTEASES AS PREDICTORS FOR APPROPRIATE ICD INTERVENTION IN PATIENTS WITH LEFT VENTRICULAR DYSFUNCTION
Authors: Helge I. Lehmann, Carmen Wolke, Wiebke Malenke, Friedrich-Wilhelm Röhl, Matthias Hammwöhner, Alicja Bukowska, Uwe Lendeckel, Andreas Goette
Journal: Journal of the American College of Cardiology (2011)
Calcitonin gene-related peptide in myocardial ischaemia and reperfusion in the pig
Authors: G Källner
Journal: Cardiovascular Research (1998)

Objective: In myocardial ischaemia, slow conducting capsaicin-sensitive C-fibres are activated. Apart from the mediation of pain, activation of these fibres causes release of various peptides, such as calcitonin gene-related peptide (CGRP), which is a potent vasodilator. The aim of this study was to investigate the role of CGRP in the context of myocardial ischaemia in vivo. Methods: The left anterior descending coronary artery (LAD) was occluded during 45 min in 27 anaesthetised open-chest pigs. LAD flow, mean arterial pressure (MAP), heart rate, peak dP/dt, arterial and coronary venous concentration of CGRP was measured prior to ischaemia, and during 4 h of reperfusion. The extent of myocardial infarction was measured using staining with triphenyl tetrazolium chloride. Results: Retroinfusion of CGRP (100 μg) into the ischaemic myocardium was associated with a more pronounced hyperaemia, and systemic hypotension, during early reperfusion. The infarct size in relation to the area at risk was not affected by CGRP or the CGRP antagonist CGRP(8–37), and averaged 67±3%. There were no changes in plasma CGRP levels during ischaemia or reperfusion. Conclusion: Exogenously administered CGRP can cause systemic hypotension and augments postischaemic coronary flow. In this model, no cardioprotective effect of CGRP could be proven.
Dual-targeting nanoparticles for reprogrammed T cell responses in the tumor microenvironment
Authors: Alyssa K Kosmides, Jonathan Schneck
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts One of the largest obstacles in cancer immunotherapy involves overcoming the immunosuppressive tumor microenvironment [[1][1]]. While many therapies are focused primarily on activating antigen-specific CD8+ T cells, the tumor microenvironment often expresses immunosuppressive
766 A PANEL OF GENE EXPRESSION BIOMARKERS PREDICTING SUSTAINED VIROLOGIC RESPONSE (SVR) IN CHRONIC HEPATITIS C PATIENTS (CH-C) TREATED WITH PEGYLATED INTERFERON ALPHA AND RIBAVIRIN
Authors: Z.M. Younossi, A. Baranova, M. Stepanova, A. Afendy, A. Wheeler, N. Hossain, A. Bakshi, C.D. Santini, C.L. Sigua, J. Chan, A.A. Iverson, S.P. Chang
Journal: Journal of Hepatology (2008)
Combined triiodothyronine and thyroxine.
Authors: R N Smith, S A Taylor, J C Massey
Journal: BMJ (1971)

were taken into account.As long ago as 1941 Freyberg et al.3 wrote that they were unable to demonstrate any relationship between serum gold levels, the response to therapy, and the development of toxic re- actions.Because more recent reports12 have suggested that there may be a relationship between these factors the results of serum gold determinations in a group of 50 patients are being analysed.Preliminary results so far are in agreement with Freyberg in failing to provide useful data regarding the response to therapy.
SUCCINCT: An Open-label, Single-arm, Non-randomised, Phase 2 Trial of Gemcitabine and Cisplatin Chemotherapy in Combination with Sunitinib as First-line Treatment for Patients with Advanced Urothelial Carcinoma
Authors: Thomas Geldart, John Chester, Angela Casbard, Simon Crabb, Tony Elliott, Andrew Protheroe, Robert A. Huddart, Graham Mead, Jim Barber, Robert J. Jones, Joanna Smith, Robert Cowles, Jessica Evans, Gareth Griffiths
Journal: European Urology (2014)

Gemcitabine and cisplatin chemotherapy (GC regimen) represents a standard treatment for advanced urothelial carcinoma. We performed an open-label, single-arm, non-randomised, phase 2 trial evaluating the addition of sunitinib to standard GC chemotherapy (SGC regimen). Overall, 63 treatment-naïve participants were recruited and received up to six 21-d cycles of cisplatin 70 mg/m2 (intravenously [IV], day 1) and gemcitabine 1000 mg/m2 (IV, days 1 and 8) combined with sunitinib 37.5 mg (orally, days 2–15). Following review of toxicity after the first six patients, the sunitinib dose was reduced to 25 mg for all patients. Overall response rate was 64%, with response noted in 37 of 58 patients. At 6 mo, 30 of 58 assessable patients (52%; 90% confidence interval [CI], 40–63%) were progression free. Median overall survival was 12 mo (95% CI, 9–15) and was heavily influenced by Bajorin prognostic group. Grade 3–4 toxicities were predominantly haematologic and limited the deliverability of the triple SGC regimen. The trial did not meet its prespecified primary end point of >60% patients progression free at 6 mo. Cumulative myelosuppression led to treatment delays of gemcitabine and cisplatin and dose reduction and/or withdrawal of sunitinib in the majority of cases. The triple-drug combination was not well tolerated. Phase 3 evaluation of the triple SGC regimen in advanced transitional cell carcinoma is not recommended. The addition of sunitinib to standard cisplatin and gemcitabine chemotherapy was poorly tolerated and did not improve outcomes in advanced urothelial carcinoma. Treatment delivery was limited by myelotoxicity.
For Quick Reference, Here Are Candidates' Positions on Health Care Reform
Authors: Charles Marwick
Journal: JAMA (1992)

HEALTH CARE reform—how much, in what form, and how to finance it—has become a major issue in the presidential campaign. Each candidate has his own recipe. Here, briefly summarized, are the major positions. <h3>Republicans</h3> <b>George Bush</b>offers tax credits of up to $3750 to enable low-income families to purchase basic health insurance. A similar tax deduction for health insurance premiums is provided for the middle class, members of which are defined as having annual incomes up to $80 000. Health insurance reforms are proposed that would enable small businesses to provide coverage through purchasing pools and by mandating that all health insurers provide coverage regardless of the insured's health status. Costs would be controlled by encouraging managed care, such as health maintenance organizations, and by an overhaul of the malpractice liability system. So far, Bush is the only candidate to come up with a hard figure on cost. When fully
Measurement of p-nitrophenol in the urine of residents whose homes were contaminated with methyl parathion.
Authors: Dana B Barr, Wayman E Turner, Emily DiPietro, P Cheryl McClure, Samuel E Baker, John R Barr, Kimberly Gehle, Raymond E Grissom, Roberto Bravo, W Jack Driskell, Donald G Patterson, Robert H Hill, Larry L Needham, James L Pirkle, Eric J Sampson
Journal: Environmental Health Perspectives (2002)

During the last several years, illegal commercial application of methyl parathion (MP) in domestic settings in several U.S. Southeastern and Midwestern States has affected largely inner-city residents. As part of a multiagency response involving the U.S. Environmental Protection Agency (U.S. EPA), the Agency for Toxic Substances and Disease Registry (ATSDR), and state and local health departments, our laboratory developed a rapid, high-throughput, selective method for quantifying p-nitrophenol (PNP), a biomarker of MP exposure, using isotope dilution high-performance liquid chromatography-tandem mass spectrometry. We measured PNP in approximately 16,000 samples collected from residents of seven different states. Using this method, we were able to receive sample batches from each state; prepare, analyze, and quantify the samples for PNP; verify the results; and report the data to the health departments and ATSDR in about 48 hr. These data indicate that many residents had urinary PNP concentrations well in excess of those of the general U.S. population. In fact, their urinary PNP concentrations were more consistent with those seen in occupational settings or in poisoning cases. Although these data, when coupled with other MP metabolite data, suggest that many residents with the highest concentrations of urinary PNP had significant exposure to MP, they do not unequivocally rule out exposure to PNP resulting from environmental degradation of MP. Even with their limitations, these data were used with the assumption that all PNP was derived from MP exposure, which enabled the U.S. EPA and ATSDR to develop a comprehensive, biologically driven response that was protective of human health, especially susceptible populations, and included clinical evaluations, outreach activities, community education, integrated pest management, and decontamination of homes.
Saving Office Practice
Authors: Alan R. Ertle
Journal: Annals of Internal Medicine (2004)

Letters18 May 2004Saving Office PracticeAlan R. Ertle, MD, MPH, MBAAlan R. Ertle, MD, MPH, MBAFrom The Corvallis Clinic, Corvallis, OR 97330.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-10-200405180-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I disagree with Dr. Sox's premise that medical information technology will be the savior of office practice for general internists (1). Certain aspects of care, such as prior authorization for procedures and drugs, can be improved by using computers and technology. These are highly repetitive tasks where information technology replaces an even more time-consuming method, that is, doing it by telephone. The Health Insurance Portability and Accountability Act (HIPAA) of 1996 did start out with the noble intention of streamlining standards on remittance but evolved into much more. Privacy standards outlined in HIPAA went into effect on ...Reference1. Sox HC. Saving office practice [Editorial]. Ann Intern Med. 2003;139:227-8. [PMID: 12899590] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Alan R. Ertle, MD, MPH, MBAAffiliations: From The Corvallis Clinic, Corvallis, OR 97330. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSaving Office Practice Harold C. Sox Saving Office Practice Scott Matthew Bolhack Saving Office Practice Peter Basch Saving Office Practice Harold C. Sox Metrics Cited byDietary Patterns Are Associated with Body Mass Index in a Korean PopulationReferencesLow carbohydrate?high protein diet and mortality in a cohort of Swedish womenObesity and low-carb diets in the united states: A herd behavior modelImplementation of recommendations on hypertension: The Canadian Hypertension Education ProgramLow-carbohydrate or low-fat diets for the metabolic syndrome?The Effects of Low-Carbohydrate Versus Conventional Weight Loss Diets in Severely Obese Adults: One-Year Follow-up of a Randomized TrialOverweight and Obesity in the Context of Heart FailureWe Are What We EatIsocaloric substitution of plant sterol-enriched fat spread for carbohydrate-rich foods in a low-fat, fibre-rich diet decreases plasma low-density lipoprotein cholesterol and increases high-density lipoprotein concentrationsEffects of weight loss and calorie restriction on carbohydrate metabolismDiets and Cardiovascular DiseaseNutrient distribution for type 2 diabetes: What’s a dietetics professional to do?"A calorie is a calorie" violates the second law of thermodynamics 18 May 2004Volume 140, Issue 10Page: 844KeywordsComputersDrugsHealth Insurance Portability and Accountability ActHealth careInformation technologyMotivationPatientsTaxes ePublished: 18 May 2004 Issue Published: 18 May 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Removal of Superfluous Hairs by Electrolysis
Authors: G. Smith
Journal: BMJ (1886)

was to-day ordered to have ten grains of 1uinine, and chicken-diet to-morrow.After this, the fever passed o , and he seemed to be doing Well for some days.Jtiry 29th.A globular fluctuating swelling was found at the wound of exit (behind).A trocar and cannula was introduced, and an ounce and a half of healthy pus evacuated.The abscess was apparently intermuscular.It was washed out with carbolised lotion, and dressed antiseptically.July~~F 3s.Dange was established.Augst 5th.For the last three days, his temperature had been irregular.The sinus, from the aperture of exit, extended to a point very close to the aperture of entrance ; no communication, however, could be discovered by the probe; and water injected from behind did not escape in front.A drainage-tube was inserted.He was rather constipated.His urine was slightly albuminous.August 8th.The carbolic lotion, when injected from behind, now escaped anteriorly.Temperature normal.August 10th.The sinus was shorter, and becoming narrower at both apertures.His general health and spirits were exoellent.August 27th.The sinus having made but little progress, it was saynged out with equal parts of tincture of iodine andl water.After this he made satisfactory progress, and on December 2nd was trans- ferred as convalescent to Kasauli Station-Hospital.He completely recovered, and returned to duty, in excellent health.REMARKS.-In the foregoing case, the following points wonld appear to be worthy of attention.It is remarkable that a Martini bullet, travelling at a speed practically equal to its initial velocity, should have passed directly from point to point, as described, without destroy- ing the continuity or integrity of the intestinal canal.There were no bloody stools, no emphysemna in the neighbourhood of the wound, no tenderness on pressure of the abdomen ; and, after an interval of eight days from date of injury, a solid healthy stool was passed.The builet most certaiinly passed in a direct line from aperture to aperture ; since, apart from the fact that the MIartini bullet does not pursue the erratic course frequently followed by the round ball, the probe showed, beyond all doubt, that the track of the bullet lay in a right line from the aperture of entrance to that of exit.That the kidney was per- forated is equally evident, both from the position and direction of the wound, and from the occurrence of smoky urine directly after the in-
Urethral Syndrome in Women
Authors: Richard N. Greenberg
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Dysuria, urgency, and frequency are common among sexually active women. When the usual bacterial pathogens are not isolated, affected women are said to have the urethral syndrome.<sup>1</sup>This syndrome has been attributed to a variety of sexually transmitted pathogens, including<i>Neisseria gonorrhoeae,1 Chlamydia trachomatis</i>,<sup>2,3</sup>and<i>Trichomonas vaginalis</i>. We examined 45 sexually active women who came to the emergency room of Charity Hospital in New Orleans with lower urinary tract symptoms. Urethral cultures were obtained for<i>N gonorrhoeae, C trachomatis</i>, and mycoplasmas. Urine obtained by clean catch or catheterization was cultured for aerobic bacteria and mycoplasmas. Vaginal wet mounts were examined for trichomonads and yeasts. Twenty-eight (62%) of the women had a bacterial urinary tract infection defined by isolation of at least 10<sup>5</sup>colonies of a single bacterial species per milliliter of urine. Thus, 38% of this population met the usual criteria for diagnosis
Abstract 1059: EGF induces epithelial-mesenchymal transition and cancer stem cell properties in human oral squamous cell carcinoma
Authors: Qilin Xu, Qunzhou Zhang, Anh Le
Journal: Cancer Research (2014)

Abstract Head and neck cancer is one of the 10 most common cancers worldwide. Despite advances in therapeutic research in the last few decades, morbidity and mortality remain unchanged. Recurrent and metastatic oral squamous cell carcinoma (OSCC) of the head and neck may have correlated with epithelial-mesenchymal transition (EMT), a property acquired by cancer stem cells (CSCs). In our study, SCC-1 cells (a human tongue cancer cell line) treated with epidermal growth factor (EGF) underwent EMT as confirmed by morphological changes and expression of EMT-related markers using Western blot, immunocytostaining, and flow cytometric analyses. Our data showed that, in comparison with non-treated cells, EGF treatment induced SCC-1 cells to undergo EMT, characterized by spindle-shaped mesenchymal-like morphology, an altered suppression of E-cadherin and promotion of vimentin expression, and an enhanced invasive capacity. Our results also indicated that EGF significantly enriched the fraction of CD44+/CD24low/- CSCs in SCC-1 cells, from 7∼8% to 25∼29%, and simultaneously increased the expression of aldehyde dehydrogenase 1 (ALDH1), a common marker for stem cells. Moreover, the purified CD44+/CD24low/- CSC population displayed stem cell properties associated with EMT phenotypes and increased migration and invasion abilities in vitro. Using a murine orthotopic tongue cancer model transplanted with stably GFP-expressing SCC-1 cells (GFP-SCC-1), we confirmed that EGF can promote tumor metastasis to cervical lymph nodes, and simultaneously augmented CD44 and ALDH1 expression in these invasive tumor cells. Taken together, we have demonstrated that EGF-induced EMT process is closely associated with the acquisition of CSC properties in human OSCC, which may contribute to the increased distant metastasis and recurrence of head and neck cancer. Further elucidation of the underlying mechanisms will facilitate development of new generation of effective therapies that aim to specifically target CSCs and eliminate the “root” of cancer recurrence. This work was supported by National Institute of Health Research Grant, R01DE 019932, Oral and Maxillofacial Surgery Foundation Research Support, 002894, and the Schoenleber funding support. Citation Format: Qilin Xu, Qunzhou Zhang, Anh Le. EGF induces epithelial-mesenchymal transition and cancer stem cell properties in human oral squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1059. doi:10.1158/1538-7445.AM2014-1059
Association Between Neurologic Improvement With Decline in Blood Pressure and Recanalization in Stroke
Authors: Nandakumar Nagaraja, Steven Warach, Amie W. Hsia, Harold P. Adams, Sungyoung Auh, Lawrence L. Latour, José G. Merino
Journal: JAMA Neurology (2014)

Patients with stroke often have a decline in blood pressure after thrombolysis. Neurologic improvement could result from recanalization or better collateral flow despite persistent occlusion. We hypothesized that neurologic improvement with concurrent decline in blood pressure may be a clinical sign of recanalization after intravenous tissue plasminogen activator.Patients treated with intravenous tissue plasminogen activator at Suburban Hospital, Bethesda, Maryland, and MedStar Washington Hospital Center, Washington, DC, from 1999 to 2009 were included in the study if they had pretreatment and 24-hour magnetic resonance angiographic scans, National Institutes of Health Stroke Scale scores at those times, and proximal middle cerebral artery occlusion demonstrated prior to treatment. The recanalization status on 24-hour magnetic resonance angiography was classified as none, partial, or complete. Seventeen patients met study criteria. On 24-hour magnetic resonance angiography, 3 patients had no recanalization, 8 had partial recanalization, and 6 had complete recanalization. At 24 hours after thrombolysis, neurologic improvement with concurrent decline in systolic blood pressure of 20 mm Hg or greater was seen in 4 patients with partial recanalization, 4 patients with complete recanalization, and none of the patients with no recanalization.Neurologic improvement with concurrent decline in systolic blood pressure of 20 mm Hg or greater after intravenous tissue plasminogen activator may be a clinical sign of recanalization. This observation needs confirmation in a larger cohort.
SOME ACUTE ABDOMINAL CASES
Authors: G. F. Aldous
Journal: BMJ (1913)

SOMIE ACUTE ABDOMINAL CASES.THME,DtTLSR 1349 and-in these I always find associated diaunges in the lower iletitii, and nsually in tll large intestine.In tlhi normal cases thle duo-ldenutim is small and shbrt, and the bismulth is seen to pass tlhroualh it by active peristalsis, witlhoutt delay or reaurgitatioln, inlto tlhe jejtitiuium as soon as the patient is placed in-tlh6 supine 'post-Lre from the riglt -lateral position.Moreover, siiy resuLlts, botlh normial and abnormal, are'repeatedly clhecked at operations, and the acttual state&6f the duolodeniunm is fouind to agree closely witlh my.previoiis a-ccount of it.In a thlini suLbject I lhave seen tlhe duodenum dilated and slhowincr strona "' writliieg " peristalsis thouglh it conitained no bismtutlh-in fact notlhing bnt Benger's food:4. "The larger the dose of bismuith the greater will be the delay in its passageth1rough the intestines; conse- (juently the intestinial stasis, if present, will seem to be greater than wotild be the case withi ordinary food, and .stasismay appear to be pr-esent whien there is nio stasis to ordiiiary food."TThe formiier part of thlis assertion is true to a, slighit extent (thioiigh1 the laxative 'action of the siu,gar of miilk prevents delay in most cases), but as all nmy
Short-term prophylaxis with cefotaxime for prostatic surgery.
Authors: T B Hargreave, J R Hindmarsh, R Elton, G D Chisholm, J C Gould
Journal: BMJ (1982)

A randomised controlled trial of a new cephalosporin, cefotaxime, was carried out in men undergoing transurethral resection of the prostate. The purpose of the trial was to determine whether 48-hour prophylaxis with this new broad-spectrum, non-nephrotoxic cephalosporin would reduce postoperative bacteriuria and postoperative complications. The treated patients fared significantly better than the non-treated patients in having fewer febrile episodes, fewer episodes of tachycardia, a lower incidence of appreciable bacteriuria postoperatively, and fewer complications, and spending on average one day less in hospital. There was no difference in postoperative urea and creatinine concentrations between the groups, and no other side effects of cefotaxime occurred in this elderly population. Prophylaxis with cefotaxime would appear to make prostatic surgery safer.
Foreign Bodies in the Ear.
Authors: G. A. Hill
Journal: JAMA (1900)

Philadelphia, Dec. 11, 1900. <h3>To the Editor:</h3> —In an abstract, from<i>Le Presse Médicale</i>, Paris, of an article by M. Lermoyez, the author says "that hundreds of lives would be saved every year if physicians, parents and nurses realized that a foreign body in the ear does no harm as long as it is not meddled with, etc." To any physician having a considerable experience with foreign bodies in the ear, such a statement will appear quite as ridiculous as it is untrue. In fact, the whole paragraph would indicate the writer to be a timid neophyte, whose first attempt in this line had resulted in nothing less than the tragic demise of his suffering patient at the hands of the trembling operator, whose death-dealing instrument had pierced some vital spot. In no cavity of the body, scarcely excepting the orbit, is a foreign body, if allowed to remain, capable