tbuckley/cabot-search huggingface dataset:
Brachial Flow-Mediated Dilation Predicts Incident Cardiovascular Events in Older Adults
Authors: Joseph Yeboah, John R. Crouse, Fang-Chi Hsu, Gregory L. Burke, David M. Herrington
Journal: Circulation (2007)

Background— The relationship between impaired brachial flow-mediated dilation (FMD) and subsequent clinical cardiovascular events is not well established, especially in older adults whose FMD is often diminished. We assessed the hypothesis that FMD predicts incident cardiovascular events in a population-based cohort of older adults. Methods and Results— FMD was measured at the 1997 to 1998 Cardiovascular Health Study clinic visit in 2792 adults aged 72 to 98 years (82.7% white, 58.6% women) recruited at 4 clinic sites in the United States. Log-rank test and Cox proportional hazard models were used to examine the association between FMD and adjudicated cardiovascular events. A total of 674 subjects (24.1%) had an adjudicated event over the 5-year follow-up period. Event-free survival rates for cardiovascular events were significantly higher in subjects with FMD greater than the sex-specific medians than in subjects with FMD less than or equal to the sex-specific medians (78.3% versus 73.6%, log-rank P =0.006). FMD remained a significant predictor of cardiovascular events after adjustment for age, gender, diabetes mellitus, cigarette smoking, systolic and diastolic blood pressure, baseline cardiovascular disease status, and total cholesterol (hazard ratio, 0.91 [95% CI, 0.83 to 0.99], P =0.02 per unit SD of FMD) but added only ≈1% to the prognostic accuracy of the best Cox model. Brachial artery diameter was also predictive of CV events in the adjusted Cox proportional hazard model (hazard ratio, 1.12 [95% CI, 1.02 to 1.28], P =0.025) and also added ≈1% to the accuracy of our best Cox model. Conclusions— FMD is a predictor of future cardiovascular events but adds very little to the prognostic accuracy of traditional cardiovascular risk scores/factors in older adults. FMD and brachial artery diameter may have similar predictive values for cardiovascular events in older adults.
THE USE OF ETHYL CHLORID AS A GENERAL ANESTHETIC IN GYNECOLOGY.
Authors: E. E. MONTGOMERY
Journal: JAMA (1904)

<h3>DISCUSSION OF ANESTHETICS IN PRESENT USE.</h3> The suggestion of a new agent for the purpose of securing general anesthesia will possibly seem unnecessary at this time, inasmuch as the agents now employed fill nearly all the indications required in anesthetic work. When we come, however, to analyze the action of these drugs, we find each of them has disadvantages which make us long for something by which these particular annoyances can be obviated. The length of time required to secure narcosis and to eliminate the drug, aside from the actual danger of the agents, make ether and chloroform unsatisfactory agents to secure anesthesia for an examination or for a short operation. The frequently prolonged nausea and vomiting associated with or following the administration of these agents for even a short time causes the patient to hesitate about undergoing the subsequent operation when they have been employed for merely diagnostic purposes.
RESISTANCE OF BACTERIAL SPORES TO THE TRIPHENYLMETHANE DYES
Authors: Victor Burke, Horace Skinner
Journal: The Journal of Experimental Medicine (1925)

1. Bacterial spores are highly resistant to the bactericidal action of the triphenylmethane dyes. Many Bacillus anthracis and Bacillus subtilis spores resist a saturated aqueous solution of gentian violet for 24 hours at 37 degrees C. They also resist exposure to the same dye solution for 10 minutes at 80 degrees C. 2. The selective bactericidal action of these dyes applies only to the vegetative cells. Spores of the Gram-positive bacteria are more resistant to these dyes than the vegetative cells of Gram-negative bacteria. 3. The vegetative cells of Bacillus anthracis show variation in resistance to the bacteriostatic action of gentian violet. The spores of Bacillus anthracis show variation in resistance to the bactericidal action of gentian violet. 4. Bacillus anthracis can increase in resistance to the bacteriostatic action of gentian violet and grow in dye dilutions inhibiting the original culture. There is the possibility of pathogenic organisms becoming dye-resistant in the body when exposed to non-bactericidal concentrations. For this reason it is advisable to use the greatest concentration of dye compatible with tissue tolerance. 5. Since the spores of pathogenic bacteria may lie dormant for longer periods than the dyes retain their bacteriostatic action in the body frequent applications of the dye should be made in preventing infections by spore-bearing bacteria.
Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium
Authors: Karin Ekström Smedby, Claire M. Vajdic, Michael Falster, Eric A. Engels, Otoniel Martínez-Maza, Jennifer Turner, Henrik Hjalgrim, Paolo Vineis, Adele Seniori Costantini, Paige M. Bracci, Elizabeth A. Holly, Eleanor Willett, John J. Spinelli, Carlo La Vecchia, Tongzhang Zheng, Nikolaus Becker, Silvia De Sanjosé, Brian C.-H. Chiu, Luigino Dal Maso, Pierluigi Cocco, Marc Maynadié, Lenka Foretova, Anthony Staines, Paul Brennan, Scott Davis, Richard Severson, James R. Cerhan, Elizabeth C. Breen, Brenda Birmann, Andrew E. Grulich, Wendy Cozen
Journal: Blood (2008)
Development, consciousness, and the perception/mental representation distinction
Authors: Lorraine McCune
Journal: Behavioral and Brain Sciences (1999)

Perceptual symbol systems provide a welcome alternative to amodal encapsulated means of cognitive processing. However, the relations between perceived reality and internal mentation require a more differentiated approach, reflecting both developmental differences between infant and adult experience and qualitative differences between consciously perceived and mentally represented contents. Neurological evidence suggests a developmental trajectory from initial perceptual states in infancy to a more differentiated consciousness from two years of age on. Children's processing of and verbal expressions regarding motion events provides an example of the changing capacity for mental experience.
Use of a DNAemia cut-off for monitoring human cytomegalovirus infection reduces the number of preemptively treated children and young adults receiving hematopoietic stem-cell transplantation compared with qualitative pp65 antigenemia
Authors: Daniele Lilleri, Giuseppe Gerna, Milena Furione, Maria Ester Bernardo, Giovanna Giorgiani, Stefania Telli, Fausto Baldanti, Franco Locatelli
Journal: Blood (2007)
Abstract 3937: Collagen prolyl hydroxylases are essential for breast cancer metastasis.
Authors: Daniele M. Gilkes, Pallavi Chaturvedi, Saumendra Bajpai, Maimon Hubbi, Denis Wirtz, Gregg Semenza
Journal: Cancer Research (2013)

Abstract Metastasis is the leading cause of death among patients who have breast cancer. Understanding the role of the extracellular matrix in the metastatic process may lead to the development of improved therapies to treat cancer patients. Intratumoral hypoxia is found in the majority of breast cancers and is associated with an increased risk of metastasis and patient mortality. Here we demonstrate that hypoxia-inducible factor 1 activates the transcription of genes encoding collagen prolyl hydroxylases that are critical for collagen deposition by breast cancer cells. We show that expression of collagen prolyl hydroxylases promotes cancer cell alignment along collagen fibers, resulting in enhanced cancer cell invasion and metastasis to lymph nodes and lungs. We establish the prognostic significance of collagen prolyl hydroxylase mRNA expression in human breast cancer biopsies and evaluate the novel use of ethyl 3,4-dihydroxybenzoate, a prolyl hydroxylase inhibitor, which decreases tumor fibrosis and metastasis in a mouse model of breast cancer. Citation Format: Daniele M. Gilkes, Pallavi Chaturvedi, Saumendra Bajpai, Maimon Hubbi, Denis Wirtz, Gregg Semenza. Collagen prolyl hydroxylases are essential for breast cancer metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3937. doi:10.1158/1538-7445.AM2013-3937
Typing of Chlamydia psittaci to monitor epidemiology of psittacosis and aid disease control in the Netherlands, 2008 to 2013
Authors: E R Heddema, E J van Hannen, M Bongaerts, F Dijkstra, R J ten Hove, B de Wever, D Vanrompay
Journal: Eurosurveillance (2015)

Binary file ES_Abstracts_Final_ECDC.txt matches
P2-328: Is pemetrexed more effective in adenocarcinoma and large cell lung cancer than in squamous cell carcinoma? A retrospective analysis of a phase III trial of pemetrexed vs docetaxel in previously treated patients with advanced non-small cell lung cancer (NSCLC)
Authors: Patrick Peterson, Keunchil Park, Frank Fossella, Ulrich Gatzemeier, William John, Giorgio Scagliotti
Journal: Journal of Thoracic Oncology (2007)
A Randomized Controlled Trial Comparing Everting Sutures with Everting Sutures and a Lateral Tarsal Strip for Involutional Entropion
Authors: Marius A. Scheepers, Ravi Singh, James Ng, Doris Zuercher, Andrew Gibson, Catey Bunce, Ken Fong, Michel Michaelides, Jane Olver
Journal: Ophthalmology (2009)
STRESS AND REDISTRIBUTION GATED SPECT THALLIUM IMAGING FOR DETECTION OF CORONARY ARTERY DISEASE
Authors: John J. Pippin, Joleno Durham, Tim D. Payne, Mary A. Brodie, Oklahoma Heart
Journal: Clinical Nuclear Medicine (1994)

Pippin, John J.; Durham, Joleno; Payne, Tim D.; Brodie, Mary A.; Heart, Oklahoma Author Information
False-Negative Computerized Tomography in Brain Tumor
Authors: Robert L. Tentler
Journal: JAMA (1977)

COMPUTERIZED axial tomography (CT) has been used in clinical neuroradiology for slightly less than four years and is considered to be the most effective means for diagnosing brain tumors. Diagnosis by CT of cerebral infarction,<sup>1</sup>cerebral and intraventricular hemorrhage,<sup>2</sup>and brain tumors<sup>3</sup>has been reported. Refinements of technique, especially the intravenous injection of iodinated contrast material,<sup>4</sup>have led to increased yields in tumor diagnosis. Tumors are being discovered at a rate not achieved with isotope scanning<sup>5</sup>and at a rate equal to arteriography without its concomitant risk. Such successes, however, may lead to an unwarranted assumption that a tumor does not exist if it does not visualize on CT scan. We report a case of false-negative CT scan in a patient who had a brain tumor. <h3>Report of a Case</h3> A 52-year-old, right-handed woman was seen for the first time on Sept 3, 1976. On
Reaction of Fish Insulins with Human Insulin Antiserums
Authors: Rosalyn S. Yalow, Solomon A. Berson
Journal: New England Journal of Medicine (1964)

VIRTUALLY all human subjects treated with insulin shortly develop circulating insulin-binding antibodies that are demonstrable by a variety of technics employing I131-labeled insulin.1 2 3 The formation of insulin-antibody complexes in human antiserums is a reversible reaction for which various kinetic and thermodynamic constants have been determined quantitatively.4 Insulin-binding capacities of antiserums from subjects that are not clinically resistant to insulin rarely exceed 10 to 20 units of insulin per liter of plasma whereas binding capacities of all but 1 of 54 antiserums from insulin-resistant subjects ranged from 57 to 4700 units per liter.5 Although individual antiserums showed similar insulin-binding capacities . . .
Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium
Authors: Hung‐Fat Tse, Chung‐Wah Siu, Shu‐Guang Zhu, Liao Songyan, Qing‐Yong Zhang, Wing‐Hon Lai, Yok‐Lam Kwong, John Nicholls, Chu‐Pak Lau
Journal: European Journal of Heart Failure (2007)
Detection and quantification of 8-hydroxydeoxyguanosine adducts in peripheral blood of people exposed to ionizing radiation.
Authors: V L Wilson, B G Taffe, P G Shields, A C Povey, C C Harris
Journal: Environmental Health Perspectives (1993)

Ionizing radiation produces a variety of damaging insults to nucleic acids, including the promutagenic lesion 8-hydroxydeoxyguanosine. In the present study, the 8-hydroxydeoxyguanosine content of peripheral blood leukocyte DNA isolated from individuals exposed to therapeutic doses of ionizing radiation was determined by a HPLC-coupled 32P-postlabeling assay. Peripheral blood leukocyte DNA from individuals irradiated with 180-200 cGy were observed to contain 2-4.5 times as much 8-hydroxydeoxyguanosine as that from unexposed individuals. These results were confirmed by the use of a HPLC-coupled electrochemical detection system. Thus, human exposure to ionizing radiation significantly increased the circulating leukocyte DNA content of 8-hydroxydeoxyguanosine.
Plasma boron and the effects of boron supplementation in males.
Authors: N R Green, A A Ferrando
Journal: Environmental Health Perspectives (1994)

Recently, a proliferation of athletic supplements has been marketed touting boron as an ergogenic aid capable of increasing testosterone. The effect of boron supplementation was investigated in male bodybuilders. Ten male bodybuilders (aged 20 to 26) were given a 2.5-mg boron supplement, while nine male bodybuilders (aged 21 to 27) were given a placebo for 7 weeks. Plasma total and free testosterone, plasma boron, lean body mass, and strength measurements were determined on day 1 and day 49 of the study. A microwave digestion procedure followed by inductively coupled argon plasma spectroscopy was used for boron determination. Twelve subjects had boron values at or above the detection limit with median value of 25 ng/ml (16 ng/ml lower quartile and 33 ng/ml upper quartile). Of the ten subjects receiving boron supplements, six had an increase in their plasma boron. Analysis of variance indicated no significant effect of boron supplementation on any of the other dependent variables. Both groups demonstrated significant increases in total testosterone (p < 0.01), lean body mass (p < 0.01), and one repetition maximum (RM) squat (p < 0.001) and one RM bench press (p < 0.01). The findings suggest that 7 weeks of bodybuilding can increase total testosterone, lean body mass, and strength in lesser-trained bodybuilders, but boron supplementation affects these variables not at all.
Practical Problems in the Respiratory Care of Patients with Muscular Dystrophy
Authors: P.E.M. Smith, P.M.A. Calverley, R.H.T. Edwards, G.A. Evans, E.J.M. Campbell
Journal: New England Journal of Medicine (1987)

THE muscular dystrophies comprise several groups of inherited disorders with a wide variation between the groups in the distribution and severity of muscle involvement.1 The respiratory muscles, in common with other skeletal muscles, are affected in all types of muscular dystrophy, so that patients have an increased risk of respiratory complications and premature death.2 Respiratory insufficiency often remains covert because impaired skeletal-muscle function prevents patients from exceeding their limited ventilatory capacity; however, it can easily be detected with routine pulmonary-function tests. The case for regular pulmonary assessment in neuromuscular disease has recently been cogently argued in the Journal.3 The . . .
Kidney Disease and Pregnancy
Authors: B. S. Strauch, J. P. Hayslett
Journal: BMJ (1974)

The course of 41 pregnancies was studied in 25 patients with renal disease. Histological classification of the disease in each patient was made by renal biopsy. The analysis suggests that the course of pregnancy in women with coexistent renal disease correlates with the underlying renal lesion and probably with the glomerular filtration rate and blood pressure. In patients with heavy proteinuria there is increased oedema formation, making the nephrotic syndrome a frequent complication.
Amenorrhea Associated With Carotenemia
Authors: Ekkehard Kemmann
Journal: JAMA (1983)

Data are presented for ten women with anovulation, nine of them with amenorrhea, who have associated carotenemia. Classic explanations for carotenemia in amenorrheic patients have been weight loss or anorexia nervosa, yet carotenemia in our patients appeared to be diet induced. All patients consumed a pure or predominantly vegetarian diet; there was no intake of red meats. Clinical and laboratory data of the patients are presented. The amenorrhea of the patient is consistent with hypothalamic hypogonadotropic anovulation (HHA). It appeared that diet modification not only led to reduction in carotene levels, but also improved the menstrual status. The association of carotenemia and menstrual disorders is reviewed. The possibility that carotenemia is related to the development of HHA is discussed.
Primary intestinal follicular lymphoma diagnosed by video capsule endoscopy and double-balloon enteroscopy
Authors: C. van Deursen, J. Goedhard, K.-S. Jie, P. Theunissen
Journal: Endoscopy (2008)

A 56-year-old woman presented with a 2-year history of large-volume diarrhea. Examination and investigations for diarrhea, palpitations, and flushes in 2004 revealed no abnormalities – in particular, the H2 breath test with lactose and 24-hour urinary metanephrine and 5-hydroxyindoleacetic acid (5HIAA) levels were normal. At the time of this recent presentation there were no abnormalities found on physical examination and routine laboratory tests were also normal, including the thyroid-stimulating hormone and the tissue transglutaminase levels; the gastrin level was 65 ng/L (normal range 0 – 110 ng/L) and the vasoactive intestinal peptide was < 5 ng/L. The fecal weight was 417–1800 g per 24 hours.
Review: In asthma controlled with ICSs plus LABAs, stopping LABAs increases asthma impairment
Authors: Jaspal Singh
Journal: Annals of Internal Medicine (2012)

Source Citation Brozek JL, Kraft M, Krishnan JA, et al. Long-acting β2-agonist step-off in patients with controlled asthma: systematic review with meta-analysis. Arch Intern Med. 2012;172:1365-75. 22928176
Intra-arterial Therapy For Neoplasms
Authors: Herman A. Freckman
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Tindel's communication (<b>200</b>:913, 1967) reports his experience with 28 intra-arterial infusions in 25 patients with recurrent regional neoplastic diseases, and Creech's editorial (<b>200</b>:983) in reference to this article also conveys the general impression that intraarterial chemotherapy is a dangerous procedure of doubtful benefit. (Other authors have reported similar experiences in larger series, particularly in reference to complications.) I totally disagree that intra-arterial chemotherapy is a dangerous procedure of doubtful benefit. To condemn an effective modality of chemotherapy on the basis of one investigator's results, and in only 25 cases, is not justified and compromises scientific judgment. I personally have performed over 3,600 intra-arterial infusions on more than 1,200 patients from 1960 to the present time, infusing all regional areas of the body from the head to the foot. Thirty percent of the first 900 patients treated had an objective response rate of six months' to
Fibrosarcoma of the trachea with severe tracheal obstruction
Authors: A. J. Roncoroni, R. J. M. Puy, E. Goldman, R. Fonseca, G. Olmedo
Journal: Thorax (1973)

<h3>Abstract</h3> <h3>Background</h3> Since its first appearance in December 2019, the novel <i>Severe Acute Respiratory Syndrome Coronavirus type 2</i> (SARS-CoV-2), spread worldwide causing an increasing number of cases and deaths (35,537,491 and 1,042,798, respectively at the time of writing, https://covid19.who.int). Similarly, the number of complete viral genome sequences produced by Next Generation Sequencing (NGS), increased exponentially. NGS enables a rapid accumulation of a large number of sequences. However, bioinformatics analyses are critical and require combined approaches for data analysis, which can be challenging for non-bioinformaticians. <h3>Results</h3> A user-friendly and sequencing platform-independent bioinformatics pipeline, named SARS-CoV-2 RECoVERY (REconstruction of CoronaVirus gEnomes &amp; Rapid analYsis) has been developed to build SARS-CoV-2 complete genomes from raw sequencing reads and to investigate variants. The genomes built by SARS-CoV-2 RECoVERY were compared with those obtained using other software available and revealed comparable or better performances of SARS–CoV2 RECoVERY. Depending on the number of reads, the complete genome reconstruction and variants analysis can be achieved in less than one hour. The pipeline was implemented in the multi-usage open-source Galaxy platform allowing an easy access to the software and providing computational and storage resources to the community. <h3>Conclusions</h3> SARS-CoV-2 RECoVERY is a piece of software destined to the scientific community working on SARS-CoV-2 phylogeny and molecular characterisation, providing a performant tool for the complete reconstruction and variants' analysis of the viral genome. Additionally, the simple software interface and the ability to use it through a Galaxy instance without the need to implement computing and storage infrastructures, make SARS-CoV-2 RECoVERY a resource also for virologists with little or no bioinformatics skills. <h3>Availability and implementation</h3> The pipeline SARS-CoV-2 RECoVERY (REconstruction of COronaVirus gEnomes &amp; Rapid analYsis) is implemented in the Galaxy instance ARIES (https://aries.iss.it).
Mechanism of Post-parotidectomy Gustatory Sweating (the Auriculo-temporal Syndrome)
Authors: D. H. Glaister, J. R. Hearnshaw, P. F. Heffron, A. W. Peck, D. H. Patey
Journal: BMJ (1958)

The methods adopted to establish a blood bank in Cyprus are described.The ABO frequencies of the two main racial stocks in Cyprus are so similar as to suggest a common ethnic derivation.The ABO frequencies in Cyprus resemble those of the inhabitants of the adjacent mainland rather than those in Greece.The resemblance is so close as to suggest that Cypriots are ethnically related to their neighbours on the Asiatic mainlaind.I thank Dr. A. E. Mourant for supplies of grouping and typing sera without which this work could not have been carried out.To the staff of the blood bank I am greatly indebted for their unwearying assistance, sometimes under difficult conditions, and in particular to the