tbuckley/cabot-search huggingface dataset:
Distress Over Book Review
Authors: ERIC BECK
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 February 1976Distress Over Book ReviewERIC BECK, M.B., F.R.C.P., JOHN FRANCIS, M.B., ROBERT SOUHAMI, M.D.ERIC BECK, M.B., F.R.C.P.Search for more papers by this author, JOHN FRANCIS, M.B.Search for more papers by this author, ROBERT SOUHAMI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-2-225_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We are writing to you about the review of our book, Differential Diagnosis, which appeared in May (Ann Intern Med 82:726, 1975). We are distressed at a review that contains so many inaccuracies and unpleasant insinuations.Your reviewer states that our book mentions "little regarding cutaneous, neurologic, urologie, or gynaecologic disorders." We state quite clearly in our introduction that the book concerns itself with the specialty of general medicine, or internal medicine as it is called in the United States. Discussions of gynaecological and skin diseases are therefore out of place as presenting symptoms and are beyond...References1. FAGIN R and KIRSNER J: Ischemic diseases of the colon. Adv Intern Med 17:343-362, 1971 MedlineGoogle Scholar2. POPE C: In Gastrointestinal Disease—Pathophysiology— Diagnosis—Management, by SLEISENGER MH, FORTRAN JS. Philadelphia, W. B. Saunders Co., 1973, p. 107 Google Scholar3. DAVENPORT H: The Digestive Tract, 3rd. ed. Chicago, Year Book Medical Publishers, Inc., 1971, pp. 168-170 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERIC BECK, M.B., F.R.C.P.; JOHN FRANCIS, M.B.; ROBERT SOUHAMI, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1976Volume 84, Issue 2 Page: 225-226 Keywords Skin diseases ePublished: 1 December 2008 Issue Published: 1 February 1976 PDF downloadLoading ...
Integration and Sequencing of Treatment Approaches for Eating Disorders
Authors: David M. Garner, Paul E. Garfinkel, Jane Irvine
Journal: Psychotherapy and Psychosomatics (1986)

General principles for the management of eating disorders are viewed with particular emphasis on correcting disturbed eating and weight within the current cultural context. A range of different therapeutic options are outlined with indications for the integration and sequencing of these as part of a multidimensional model of treatment.
Normolipaemic xanthomas in association with human immunodeficiency virus infection
Authors: H.M. Ramsay, M.C. Garrido, A.G. Smith
Journal: British Journal of Dermatology (2000)

S ir, We report a case of the association of normolipaemic xanthomas with human immunodeficiency virus (HIV) infection. A 42‐year‐old homosexual male with acquired immune deficiency syndrome (AIDS) developed asymptomatic yellow papules and plaques on the forehead and cheeks (Fig. 1a). AIDS had been diagnosed 3 years previously on the basis of an episode of Pneumocystis pneumonia and positive HIV‐serology. Since then his general health had been good, although he had required treatment for facial seborrhoeic dermatitis. At the time of presentation to dermatology his HIV viral load was < 400,000 copies/mL and CD4 count 0·31 × 109/L on triple antiretroviral therapy of ritinovir, lamivudine and stavudine. Fasting lipid and lipoprotein profiles, complement studies, plasma glucose, liver and thyroid function were normal. A non‐clonal rise in IgA of 448 IU (normal 50–267) with normal IgG and IgM was found. No serum paraprotein or urinary light chains were detected. Twenty‐four‐hour urinary microalbumin excretion (a marker of general increased vascular permeability 1) was within normal limits. Biopsy of one of the forehead lesions (Fig. 1b) confirmed the clinical diagnosis of plane xanthoma with nodular groups of foamy histiocytes in the reticular dermis. No Touton giant cells, refractile material or altered collagen were seen; neutrophils, leucocytoclasis and eosinophils were absent and perivascular lymphocytes sparse. Monoclonal antibody studies demonstrated immunoglobulins of all classes in association with the dermal foam cells.
Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia
Authors: J-M Luo, H Yoshida, S Komura, N Ohishi, L Pan, K Shigeno, I Hanamura, K Miura, S Iida, R Ueda, T Naoe, Y Akao, R Ohno, K Ohnishi
Journal: Leukemia (2003)
ABSENCE OF CORONARY ARTERY CALCIUM DOES NOT FULLY EXCLUDE OBSTRUCTIVE CORONARY ARTERY DISEASE AND FUTURE ADVERSE EVENTS AMONG PATIENTS REFERRED FOR CARDIAC CT ANGIOGRAPHY: RESULTS FROM 17,528 PATIENTS IN THE CONFIRM REGISTRY (CORONARY CT ANGIOGRAPHY EVALUATION FOR CLINICAL OUTCOMES: AN INTERNATIONAL MULTICENTER REGISTRY)
Authors: Todd C. Villines, Edward Hulten, Alison Dunning, Leslee J. Shaw, Stephan Achenbach, Mouaz Al-Mallah, Daniel S. Berman, Matthew J. Budoff, Filippo Cademartiri, Tracy Callister, Hyuk-Jae Chang, Benjamin J.W. Chow, Augustine Delago, Martin Hadamitzky, Joerg Hausleiter, Philipp Kaufmann, Fay Y. Lin, Gilbert L. Raff, Manju Goyal, James K. Min
Journal: Journal of the American College of Cardiology (2011)
Angiographic Patterns of In-Stent Restenosis
Authors: Roxana Mehran, George Dangas, Andrea S. Abizaid, Gary S. Mintz, Alexandra J. Lansky, Lowell F. Satler, Augusto D. Pichard, Kenneth M. Kent, Gregg W. Stone, Martin B. Leon
Journal: Circulation (1999)

Background —The angiographic presentation of in-stent restenosis (ISR) may convey prognostic information on subsequent target vessel revascularizations (TLR). Methods and Results —We developed an angiographic classification of ISR according to the geographic distribution of intimal hyperplasia in reference to the implanted stent. Pattern I includes focal (≤10 mm in length) lesions, pattern II is ISR&gt;10 mm within the stent, pattern III includes ISR&gt;10 mm extending outside the stent, and pattern IV is totally occluded ISR. We classified a total of 288 ISR lesions in 245 patients and verified the angiographic accuracy of the classification by intravascular ultrasound. Pattern I was found in 42% of patients, pattern II in 21%, pattern III in 30%, and pattern IV in 7%. Previously recurrent ISR was more frequent with increasing grades of classification (9%, 20%, 34%, and 50% for classes I to IV, respectively; P =0.0001), as was diabetes (28%, 32%, 39%, and 48% in classes I to IV, respectively; P &lt;0.01). Angioplasty and stenting were used predominantly in classes I and II, whereas classes III and IV were treated with atheroablation. Final diameter stenosis ranged between 21% and 28% ( P =NS among ISR patterns). TLR increased with increasing ISR class; it was 19%, 35%, 50%, and 83% in classes I to IV, respectively ( P &lt;0.001). Multivariate analysis showed that diabetes (odds ratio, 2.8), previously recurrent ISR (odds ratio, 2.7), and ISR class (odds ratio, 1.7) were independent predictors of TLR. Conclusions —The introduced angiographic classification is prognostically important, and it may be used for appropriate and early patient triage for clinical and investigational purposes.
Nonadrenergic noncholinergic relaxation of human pulmonary arteries is partially mediated by nitric oxide.
Authors: J A Scott, I Craig, D G McCormack
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Nonadrenergic noncholinergic (NANC) vasodilator mechanisms may contribute to the maintenance of low vascular resistance characteristic of the pulmonary circulation. Previous studies have demonstrated that nitric oxide (NO) is the principal NANC neurotransmitter in guinea pig pulmonary arteries. We examined whether NANC relaxation could be demonstrated in human pulmonary arteries, and the role of NO in this phenomenon. Fresh human pulmonary artery rings, with and without an intact endothelium, were mounted in organ baths containing Krebs' solution and precontracted with U44069 (0.3 microM). Adrenergic and cholinergic neurotransmitter pathways were blocked with guanethidine and atropine, respectively (10 microM each). In both endothelium-intact and -denuded vessels, electrical field stimulation (EFS, 1 to 10 Hz, 100 V) resulted in a frequency-dependent relaxation (maximal relaxation of 25 +/- 4% and 15 +/- 2% in endothelium-intact and -denuded vessels, respectively). Tetrodotoxin (0.3 microM) abolished the EFS-induced relaxation. L-NG-nitro-arginine methyl ester (L-NAME, 10 microM), was used to block enzymatic synthesis of NO. In both endothelium-intact and -denuded vessels, L-NAME reduced NANC relaxation to approximately 50% of control values. This reduction was reversible with the application of L-arginine (100 microM). We conclude that NANC relaxation exists in human pulmonary arteries and that it is partly mediated through NO.
Prediction of Restenosis After Coronary Angioplasty by Use of a New Index
Authors: Goran Stankovic, Athanassios Manginas, Vassilis Voudris, Gregory Pavlides, George Athanassopoulos, Miodrag Ostojic, Dennis V. Cokkinos
Journal: Circulation (2000)

It has been shown recently that postangioplasty coronary flow reserve and the degree of residual stenosis have a modest predictive value for short- and long-term clinical outcomes after coronary angioplasty. Corrected TIMI frame count (CTFC) is a simple quantitative index of coronary blood flow. Its relationship with Doppler coronary flow velocity and clinical outcome after coronary angioplasty has not been fully clarified. The aim of this study was to identify clinical, angiographic, and functional predictors of clinical and angiographic restenosis after conventional coronary angioplasty.We studied 70 consecutive patients in whom intracoronary Doppler flow-velocity measurements were performed before and after angioplasty. Patients were evaluated for restenosis by clinical follow-up, exercise stress test/(201)Tl scintigraphy, and follow-up angiography, which was performed at 10. 5+/-10.3 months in 63 patients. According to the results of univariate analysis, a new index, postangioplasty CTFC/minimal luminal diameter (MLD) ratio, was created. Multivariate analysis revealed that CTFC/MLD ratio was the only independent predictor of angiographic (OR 2.02; 95% CI 1.37 to 2.97; P<0.0004) and clinical (OR 1.60; 95% CI 1.15 to 2.21; P<0.005) restenosis. The receiver operating characteristic curve area of this index was 79% for angiographic and 73% for clinical restenosis. The optimal CTFC/MLD ratio cutoff values were 7.88 for angiographic and 7.94 for clinical restenosis, respectively.Our data indicate that postangioplasty CTFC/MLD ratio, which incorporates both the angiographic and functional features of coronary lesions, is a reliable, objective, and inexpensive index for prediction of angiographic and clinical restenosis after conventional coronary angioplasty.
ADAR1 Is Involved in the Development of Microvascular Lung Injury
Authors: Reuven Rabinovici, Koroush Kabir, Meihong Chen, Yingjun Su, Dexin Zhang, Xiaoxing Luo, Jing-Hua Yang
Journal: Circulation Research (2001)

Abstract —Deamination of adenosine on pre-mRNA to inosine is a recently discovered process of posttranscription modification of pre-mRNA, termed A-to-I RNA editing, which results in the production of proteins not inherent in the genome. The present study aimed to identify a role for A-to-I RNA editing in the development of microvascular lung injury. To that end, the pulmonary expression and activity of the RNA editase ADAR1 were evaluated in a mouse model of endotoxin (15 mg/kg IP)–induced microvascular lung injury (n=5) as well as in cultured alveolar macrophages stimulated with endotoxin, live bacteria, or interferon. ADAR1 expression and activity were identified in sham lungs that were upregulated in lungs from endotoxin-treated mice (at 2 hours). Expression was localized to polymorphonuclear and monocytic cells. These events preceded the development of pulmonary edema and leukocyte accumulation in lung tissue and followed the local production of interferon-γ, a known inducer of ADAR1 in other cell systems. ADAR1 was found to be upregulated in alveolar macrophages (MH-S cells) stimulated with endotoxin (1 to 100 μg/mL), live Escherichia coli (5×10 7 colony-forming units), or interferon-γ (1000 U/mL). Taken together, these data suggest that ADAR1 may play a role in the pathogenesis of microvascular lung injury possibly through induction by interferon.
Bezafibrate suppresses rat antiglomerular basement membrane crescentic glomerulonephritis
Authors: Daisuke Saga, Minoru Sakatsume, Asa Ogawa, Yutaka Tsubata, Yoshikatsu Kaneko, Takeshi Kuroda, Fuminori Sato, Junya Ajiro, Daisuke Kondo, Takashi Miida, Ichiei Narita, Fumitake Gejyo
Journal: Kidney International (2005)
Physicians on Aeromedical Teams
Authors: Charles Shufflebarger, Ricard Townsend
Journal: JAMA (1987)

<h3>To the Editor.—</h3> We congratulate Baxt and Moody<sup>1</sup>for their study on the effect of flight crew composition on the mortality of helicopter-transported trauma victims. A few additional comments may aid in the interpretation of these data. First, strict comparison of the probability of survival (<i>P</i><sub>s</sub>) of patients who died in each group is not presented. Although<i>P</i><sub>s</sub>strata were "statistically similar," the vast majority of patients had a<i>P</i><sub>s</sub>lower than.95. Only 76 patients (36 treated by a nurse/paramedic team and 40 treated by a nurse/physician team) had a<i>P</i><sub>s</sub>of.95 or less, and only 38 (16 treated by a nurse/paramedic team and 22 treated by a nurse/physician team) had a<i>P</i><sub>s</sub>of.50 or less. Including large numbers of patients with low-risk injuries would statistically alter the effects of intervention on the small number of patients with more critical injuries. Statistical significance within the
Increased Mortality and Aggravation of Heart Failure in Estrogen Receptor-β Knockout Mice After Myocardial Infarction
Authors: Theo Pelzer, Paula-Anahi Arias Loza, Kai Hu, Barbara Bayer, Charlotte Dienesch, Laura Calvillo, John F. Couse, Kenneth S. Korach, Ludwig Neyses, Georg Ertl
Journal: Circulation (2005)

Background— Lower mortality rates among women with chronic heart failure than among men may depend in part on the action of female sex hormones, especially estrogens. The biological effects of estrogens are mediated by 2 distinct estrogen receptor (ER) subtypes (ERα and ERβ). The present study was undertaken to determine the role of ERβ in the development of chronic heart failure after experimental myocardial infarction (MI). Methods and Results— Female ERβ null mice (BERKO Chapel Hill ) and wild-type littermates (WT) were ovariectomized, given 17β-estradiol, and subjected to chronic anterior MI (MI; BERKO n=31, WT n=30) or sham operation (sham; BERKO n=14, WT n=14). At 8 weeks after MI, both genotypes revealed left ventricular remodeling and impaired contractile function at similar average infarct size (BERKO-MI 32.9±5% versus WT-MI 33.0±4%); however, BERKO mice showed increased mortality (BERKO-MI 42% versus WT-MI 23%), increased body weight and fluid retention ( P &lt;0.01), higher ventricular pro-ANP expression (BERKO-MI 27.9-fold versus sham, WT-MI 5.2-fold versus sham; BERKO-MI versus WT-MI P &lt;0.001), higher atrial natriuretic peptide serum levels, and increased phospholamban expression ( P &lt;0.05) compared with WT mice. Conclusions— Systemic deletion of ERβ in female mice increases mortality, aggravates clinical and biochemical markers of heart failure, and contributes to impaired expression of Ca 2+ -handling proteins in chronic heart failure after MI. Further studies are required to delineate the relative importance of cardiac and vascular effects of ERβ and the role of ERα in the development of heart failure.
Inositol Phosphates and Calcium Signalling.
Authors: A. Gibson
Journal: Cardiovascular Research (1994)

Inositol Phosphates and Calcium Signalling. Get access Alan Gibson Alan Gibson London, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 6, June 1994, Page 931, https://doi.org/10.1093/cvr/28.6.931b Published: 01 June 1994
(7) Bilateral facial cavernous haemangioma
Authors: E.D.A. Potts
Journal: British Journal of Dermatology (1987)

Journal Article (7) Bilateral facial cavernous haemangioma Get access E.D.A. Potts E.D.A. Potts Halifax General Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 53–54, https://doi.org/10.1111/j.1365-2133.1987.tb12048.x Published: 01 June 1987
Stevens-Johnson Syndrome: Nonspecific Parasensitivity Reaction?
Authors: David B. Coursin
Journal: JAMA (1966)

The cause of the eruption in Stevens-Johnson syndrome is still undeterminied and the reaction probably has a multiple etiology, having been associated with systemic bacterial and viral infections, vaccination, drug therapy, pregnancy, foods, and deep x-ray treatment. It presents a problem in differential diagnosis because it may be confused with many primary bullous eruptions, eg, chickenpox and toxic epidermal necrolysis (Lyell's disease), and manifests itself as a component of the prodromal symptomatology in viral infections or as a hypersensitive reaction to a therapeutic agent used in treatment. Drugs are less often implicated than the disease process itself, but if it is suspected that a drug is a cause, the drug should be promptly withdrawn, supportive measures instituted, and—in severe cases—short-term, high dose steroid therapy administered. In its milder forms, the syndrome has a generally good prognosis.
Bootstrap-after-Bootstrap Model Averaging for Reducing Model Uncertainty in Model Selection for Air Pollution Mortality Studies
Authors: Steven Roberts, Michael A. Martin
Journal: Environmental Health Perspectives (2009)

Concerns have been raised about findings of associations between particulate matter (PM) air pollution and mortality that have been based on a single "best" model arising from a model selection procedure, because such a strategy may ignore model uncertainty inherently involved in searching through a set of candidate models to find the best model. Model averaging has been proposed as a method of allowing for model uncertainty in this context.To propose an extension (double BOOT) to a previously described bootstrap model-averaging procedure (BOOT) for use in time series studies of the association between PM and mortality. We compared double BOOT and BOOT with Bayesian model averaging (BMA) and a standard method of model selection [standard Akaike's information criterion (AIC)].Actual time series data from the United States are used to conduct a simulation study to compare and contrast the performance of double BOOT, BOOT, BMA, and standard AIC.Double BOOT produced estimates of the effect of PM on mortality that have had smaller root mean squared error than did those produced by BOOT, BMA, and standard AIC. This performance boost resulted from estimates produced by double BOOT having smaller variance than those produced by BOOT and BMA.Double BOOT is a viable alternative to BOOT and BMA for producing estimates of the mortality effect of PM.
Socioeconomic variations in the use of common surgical operations.
Authors: A Coulter, K McPherson
Journal: BMJ (1985)

The surgical experience of a sample of people aged 40-64 randomly selected from general practice lists was elicited by means of a postal questionnaire and the results examined in relation to two indicators of socioeconomic status.Eighty per cent of the sample had had one or more surgical operations and women had a higher mean number of operations than men.Those in the more advantaged groups had a higher mean number of operations than those in the less advantaged groups.This difference was, however, mainly accounted for by operations carried out in childhood before the establishment of the National Health Service and by private sector surgery.
PITUITRIN IN LABOUR
Authors: W. B. Sanders
Journal: BMJ (1914)

19 _ZD",JM" MY1,11 So my cases may have little actually to -do with the main issue.However, the symptoms were uncommonly suggestive, except for the absence of the "whoop"; yet, in the circumstances, I think I was justified in rejecting true pertussis as the diagnosis.Again, it is of great interest to read that the cases under Dr. Ross exhibited "a definite incubation period."Perhaps Dr. Ross would be kind enough to give approxi- mately the length of this, and also the duration of the whole illness from his observations.None of my cases persisted for the complete, usual, protracted course, but they varied greatly in the period of recovery from "' epidemic paroxysmal cough," as Dr. Ross has aptly suggested that the disease should be named.I am, etc.,
Puzzling out priorities
Authors: R. Klein
Journal: BMJ (1998)

Education and debate pp 1000-7 

The second international conference on priorities in health care, held in London this week, is important for two reasons. Firstly, it provides a reminder that the phenomenon of rationing is indeed international and not just a byproduct of the way Britain's National Health Service is designed or funded. Countries with very different healthcare systems and levels of healthcare spending are all grappling with the problem of how to reconcile growing demands and constrained resources. Secondly, as the three conference papers published in this issue show (pp 1000-7),1–3 it marks recognition of the fact that priority setting is inevitably messy and difficult.4 The challenge everywhere is about how to organise and orchestrate what, for the foreseeable future, will be a continuing dialogue between politicians, professionals, and the public about the principles that should be invoked in making decisions about rationing and about how best to reconcile conflicting values and competing claims.

This …
Management of Complications in Refractive Surgery
Authors: Amy Lin
Journal: JAMA (2009)

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