tbuckley/cabot-search huggingface dataset:
Procedural Results and Late Clinical Outcomes After Placement of Three or More Stents in Single Coronary Lesions
Authors: Ran Kornowski, Roxana Mehran, Mun K. Hong, Lowell F. Satler, Augusto D. Pichard, Kenneth M. Kent, Gary S. Mintz, Ron Waksman, John R. Laird, Alexandra J. Lansky, Theresa A. Bucher, Jeffrey J. Popma, Martin B. Leon
Journal: Circulation (1998)

Background —Previous reports have suggested higher procedural and long-term complications among patients treated with multiple stents for diffuse lesions and/or long dissections. Methods and Results —To evaluate procedural success, major complications, and clinical outcomes (≥1 year) in a consecutive series of patients treated with multiple (≥3) contiguous stents in single lesions, we evaluated in-hospital and long-term (1-year) clinical outcomes in 117 consecutive patients treated with ≥3 coronary stents compared with a concurrent series of patients treated with 1 or 2 stents (n=1673) between January 1, 1994, and December 31, 1995. Multiple stents were implanted more often in larger vessels, in the right coronary artery or saphenous vein grafts, and for unfavorable lesion characteristics, including long (&gt;20 mm), calcified, ulcerated, thrombotic, and/or flow-obstructing lesions. Overall procedural success was obtained in 97.4% of patients and was similar whether 1 or 2 versus ≥3 stents were used. Non–Q-wave MI (CK-MB ≥5 times normal) was more frequent after ≥3 stents (22.8% versus 13.4%, P =.005). Target lesion revascularization (TLR) was 14.6% for 1 or 2 stents and 13.3% for ≥3 stents ( P =.70). There was no difference in death (2.2% versus 0.9%, P =.34) or Q-wave MI (1.4% versus 0.9%, P =.64) between the two groups (1 or 2 stents versus ≥3 stents, respectively), and overall cardiac event–free survival was similar during follow-up ( P =.70). Conclusions —Patients treated with multiple (≥3) contiguous stents compared with 1 or 2 stents have (1) similar in-hospital procedural success and major complications despite having more unfavorable lesion characteristics, (2) a higher rate of procedural non–Q-wave MI, and (3) similar TLR and overall major cardiac event rates during 1 year of follow-up.
The Curse of Tantalus
Authors: Mark H. Beers
Journal: Annals of Internal Medicine (2005)

Letters1 February 2005The Curse of TantalusMark H. Beers, MDMark H. Beers, MDFrom Merck Research Laboratories, Philadelphia, PA 19103.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-3-200502010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the 5 October 2004 issue, Dr. Stone referenced the curse of Tantalus and stated that the king's punishment was for “some unspecified breach of protocol.” In at least one well-known version of the myth, Tantalus's offense was serving the boiled remains of his son to the gods. He did this to test their ability to see and know all things. They did; he didn't. The take-home message to the ancients was to avoid trying to outsmart the gods. However, as medical researchers, we strive every day to do just that. We must hope for a better ...Reference1. Stone JH. Methotrexate in polymyalgia rheumatica: kernel of truth or curse of Tantalus? [Editorial]. Ann Intern Med. 2004;141:568-9. [PMID: 15466775] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Merck Research Laboratories, Philadelphia, PA 19103. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMethotrexate in Polymyalgia Rheumatica: Kernel of Truth or Curse of Tantalus? John H. Stone Metrics 1 February 2005Volume 142, Issue 3Page: 228-229 ePublished: 1 February 2005 Issue Published: 1 February 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
972-107 L-Arginine Decreases Infarct Size in Rats Exposed to Environmental Tobacco Smoke
Authors: Bo-qing Zhu, Vi-ping Sun, Richard E. Sievers, Jonathan L. Shuman, Stanton A. Glantz, Kanu Chatterjee, William W. Parmley, Christopher L. Wolfe
Journal: Journal of the American College of Cardiology (1995)
Medicine by Proxy?
Authors: J. T. Evans
Journal: CA A Cancer Journal for Clinicians (1981)

contains statements which require rebuttal.The criticism of the breast consensus meeting that â€oe¿ there were more represen tatives of the media in the audience than there were physiciansâ€• detracts from the fact that the consensus statements were developed by the panelistsâ€"not the au dience.The newsworthiness of the meet of Medicine Chicago,
191 UPPER GASTROINTESTINAL BLEEDING IN CIRRHOSIS: WHAT HAS CHANGED DURING THE LAST 20 YEARS?
Authors: P. Deltenre, S. De Maeght, J.-M. Ghilain, J.-M. Maisin, M. Moulart, T. Delaunoit, D. Verset, C. Yeung, M. Schapira, J. Henrion
Journal: Journal of Hepatology (2009)
THE EFFECT OF BILATERAL FRONTAL LOBOTOMY UPON THE AUTONOMIC NERVOUS SYSTEM
Authors: M. RINKEL, M. GREENBLATT, G. P. COON, H. C. SOLOMON
Journal: American Journal of Psychiatry (1947)

1. Cortical representations of the autonomic nervous system are located in the prefrontal area. 2. Following the subcortical section of the frontal lobes, the autonomic nervous system becomes more responsive to stimuli from without. 3. Equilibrium reestablished itself on a different level. 4. With the disconnection of the frontal lobe, excitatory and inhibitory influences upon the A. N. S. are abolished, which may explain certain clinical observations such as the fall in blood-pressure in hypertensive patients. 5. Frontal lobotomy which, at present, is performed for the surgical treatment of serious mental illnesses, may, in the future, become a method for the treatment of selected cases of hypertension.
Testing the Molecular Clock: Molecular and Paleontological Estimates of Divergence Times in the Echinoidea (Echinodermata)
Authors: Andrew B. Smith, Davide Pisani, Jacqueline A. Mackenzie-Dodds, Bruce Stockley, Bonnie L. Webster, D. Timothy J. Littlewood
Journal: Molecular Biology and Evolution (2006)

The phylogenetic relationships of 46 echinoids, with representatives from 13 of the 14 ordinal-level clades and about 70% of extant families commonly recognized, have been established from 3 genes (3,226 alignable bases) and 119 morphological characters. Morphological and molecular estimates are similar enough to be considered suboptimal estimates of one another, and the combined data provide a tree that, when calibrated against the fossil record, provides paleontological estimates of divergence times and completeness of their fossil record. The order of branching on the cladogram largely agrees with the stratigraphic order of first occurrences and implies that their fossil record is more than 85% complete at family level and at a resolution of 5-Myr time intervals. Molecular estimates of divergence times derived from applying both molecular clock and relaxed molecular clock models are concordant with estimates based on the fossil record in up to 70% of cases, with most concordant results obtained using Sanderson's semiparametric penalized likelihood method and a logarithmic-penalty function. There are 3 regions of the tree where molecular and fossil estimates of divergence time consistently disagree. Comparison with results obtained when molecular divergence dates are estimated from the combined (morphology + gene) tree suggests that errors in phylogenetic reconstruction explain only one of these. In another region the error most likely lies with the paleontological estimates because taxa in this region are demonstrated to have a very poor fossil record. In the third case, morphological and paleontological evidence is much stronger, and the topology for this part of the molecular tree differs from that derived from the combined data. Here the cause of the mismatch is unclear but could be methodological, arising from marked inequality of molecular rates. Overall, the level of agreement reached between these different data and methodological approaches leads us to believe that careful application of likelihood and Bayesian methods to molecular data provides realistic divergence time estimates in the majority of cases (almost 80% in this specific example), thus providing a remarkably well-calibrated phylogeny of a character-rich clade of ubiquitous marine benthic invertebrates.
Ketotifen and nocturnal asthma.
Authors: J R Catterall, P M Calverley, J T Power, C M Shapiro, N J Douglas, D C Flenley
Journal: Thorax (1983)

Patients with asthma often wheeze at night and they also become hypoxic during sleep. To determine whether ketotifen, a drug with sedative properties, is safe for use at night in patients with asthma, we performed a double blind crossover study comparing the effects of a single 1 mg dose of ketotifen and of placebo on arterial oxygen saturation (SaO2), breathing patterns, electroencephalographic (EEG) sleep stage, and overnight change in FEV1 in 10 patients with stable asthma. After taking ketotifen, the patients slept longer and their sleep was less disturbed than after taking placebo, true sleep occupying 387 (SEM 8) minutes after ketotifen and 336 (19) minutes after placebo (p less than 0.02). On ketotifen nights the patients had less wakefulness and drowsiness (EEG sleep stages 0 and 1) and more non-rapid eye movement (non-REM) sleep than on placebo nights, but the duration of REM sleep was similar on the two occasions. Nocturnal changes in SaO2, the duration of irregular breathing, and overnight change in FEV1 were unaffected by ketotifen.
The Combined Effect of Triple Therapy with Rosiglitazone, Metformin, and Insulin Aspart in Type 2 Diabetic Patients: Response to Poulsen et al.
Authors: Nasser Mikhail
Journal: Diabetes Care (2004)

I have some concerns regarding the results of Poulsen et al.’s (1) study, which suggested that triple therapy with insulin aspart, metformin, and rosiglitazone was superior to continuing treatment with NPH insulin alone or NPH plus regular insulin (referred to as the control group). These results should be interpreted with caution because of several limitations in the study’s design. First, I disagree with the authors for applying “identical” goals for metabolic control in both study groups. Although the glycemic target was similar in both arms, the timing …
Creation of an Educational Environment
Authors: Lawrence M. Cutler
Journal: JAMA (1961)

IN THE MAIN, the objectives of an educational program are the maintenance of a high standard of medical care for all patients, the maintenance of a high standard of professional competence, and the continuity of progressive postgraduate medical education.  All of these objectives must be considered in the creation of an educational environment in hospitals without internes or residents. Saying it sounds simple enough, and it becomes an easy matter to be idealistic and describe an utopian situation with the whole program outlined on paper. However, it is quite a different matter when an attempt is made to spell it all out in terms of activity. There is hard work involved, and the difficulties are compounded mainly because of the variation in values amongst a medical staff. As a general rule, experience has shown that it is a few who set the pace, and there hasn't yet, in my opinion,
NEURASTHENIA AS MODIFIED BY MODERN CONDITIONS; AND THEIR PREVENTION.
Authors: THOMAS C. ELY
Journal: JAMA (1906)

Whether neurasthenia be a condition or a disease or whether the term itself be properly or improperly used, the fact of its existence, of its untold mystery and increasing frequency is as certain as is the fact of civilization itself. In all the fields of nervous maladies none is more widespread in its distribution and perhaps none more preventable than neurasthenia; a disease of unknown character and localization, the exact nature and seat speculative only; partly a morbid psychical asthenia and partly physical asthenia and irritability; so closely allied to hysteria and hypochondriasis that such can only be differentiated by grouping symptoms, by the symptoms-complex; simulating often degenerative diseases as tabes and general paresis<sup>1</sup>or incipient tumors; closely allied, often a seemingly transition stage, to the most grave psychic diseases; of no known pathology, except it be the late imperfect pathology of fatigue cells; the only sure known phenomena
Differential Diagnosis in Conventional Gastrointestinal Radiology
Authors: DANIEL J NOLAN
Journal: Gut (1997)

Differential Diagnosis in Conventional Gastrointestinal Radiology. Burgener FA, Kormano M. (Pp 233; illustrated; DM115.00.) Stuttgart: Georg Thieme Verlag, 1997. ISBN 0-86577-676-8.

This book is the second edition of a monograph in the Differential Diagnosis in Conventional Radiology series by Burgener and Kormano aimed at radiologists, physicians and surgeons interested in gastroenterology. There are chapters on the abnormal gas pattern, abdominal calcifications, displacement of abdominal organs, dilatation and motility disorders, narrowing, and filling defects. There is also a chapter on ulcers, diverticula and fistulae, and one on biliary tract abnormalities.

There is …
RELATION OF HYPERTENSIVE TOXEMIA OF PREGNANCY TO CHRONIC CARDIOVASCULAR DISEASE
Authors: JEAN CORWIN
Journal: JAMA (1927)

When a pregnant woman exhibits one or more of the following symptoms, she is ordinarily said to have a toxemia: (1) pernicious vomiting, (2) jaundice, (3) hypertension, (4) albuminuria, (5) edema, (6) severe anemia, (7) convulsions, (8) visual disturbances. Cases showing these symptoms fall into certain groups, which can be roughly classified on clinical or pathologic grounds as follows: (1) pernicious vomiting; (2) acute yellow atrophy of the liver; (3) acute (eclamptic) toxemia; (4) subacute or hypertensive toxemia; (5) nephritic toxemia. These seem to fall into two classes, the first including pernicious vomiting and acute yellow atrophy—types of cases which are not considered in this report: the second, including the remaining three. This classification, while arbitrary and tentative, has proved useful in treatment and prognosis.  Among the acute toxemias are placed those in which, in most instances, there is a sudden and stormy onset, and a short course with convulsions—the
Treatment of oral lichen planus with betamethasone.
Authors: R. A. Cawson
Journal: BMJ (1968)

MEDICAL JOURNAL nephritis without proteinuria (1.86 and 1.32).In three patients with low glomerular filtration rate (inulin clearance less than 10 ml./min.)we found ratios of from 1.44 up to 2.13, in agreement with the findings of Miller et al. (1952).It is pertinent to note that in all these cases the ratio 5'Cr edetic acid clearance to inulin clearance remains close to 1.00.Therefore 51Cr edetic acid clearance gives a reliable estimate of inulin clearance even in the presence of proteinuria and advanced renal failure and in other renal diseases where creatinine clearance is unreliable.Cr edetic acid is chemically inactive and has no chelating action.Downes and McDonald (1964), using large doses of Cr edetic acid in the rat, have shown that it does not cause renal damage.The total dose of "Cr edetic acid given for the purpose of measuring clearance in man is much lower than the dose administered when edetic acid is used as a chelating agent (5 mg.against 2-3,000 mg.).Ninety-eight per cent. of the Cr edetic acid administered is excreted through the kidney.Radiation dosage to the patient's kidney is comparatively trivial (Garnett et al., 1967).51Cr emits monochromatic gamma radiation of 320 keV and is easily counted with any standard well-type scintillation counter.The ease of manufacture of 51Cr edetic acid is an advantage over other labelled substances such as 5"Cr inulin (Johnson et al., 1967).The use of this substance is tlnerefore safe and convenient. SummaryExperiments in dogs have shown that the clearance of 51Cr edetic acid remains identical with the simultaneous clearance of inulin, and that it is independent of the concentration of Cr edetic acid in the plasma.Simultaneous 51Cr edetic acid, inulin, and endogenous creatinine clearances were measured in 20 patients with renal disease of various origin and a wide range of severity.The correlation between 5'Cr edetic acid and inulin clearances (r=0.992) was found to be better than the correlation between creatinine and inulin clearances (r=0.908).51Cr edetic acid is safe and convenient to use.We thank Dr. R. F. Jewkes and Miss Barbara Jones, who carried out the isotope measurements ; Dr. Pierre Verroust for help with the dog experiments ; Miss E. M
THE EFFECT OF CALIBRATION ERROR ON THE TRANSFER-FUNCTION-DERIVED CENTRAL AORTIC BLOOD PRESSURE
Authors: Hao-min Cheng, Yuan-Ta Shih, Kang-Ling Wang, Yi-Jung Sun, Ying-Hwa Chen, Shing-Jong Lin, Lung-Ching Chen, Lung-Ching Chen, Lung-Ching Chen, Shih-Hsien Sung, Wen-Shin Lee, Wen-Chung Yu, Wei-Chih Hu, Chen-Huan Chen
Journal: Journal of the American College of Cardiology (2010)
Tony Leone Ganado
Authors: J. Psaila
Journal: BMJ (2003)

Consultant anaesthetist Birmingham Heartlands and Solihull Trust (b Malta 1947; q Malta 1971), d 6 September 2003.​2003.




Figure 1




Tony Leone Ganado moved to the United Kingdom in November 1973 to take up a career in anaesthetics. Political events in the Maltese islands precluded a return to his native country and Tony and his wife, Noreen, settled in the UK, where he progressed rapidly from registrar jobs in Swindon and Coventry to a consultant post in East Birmingham Hospital (now Birmingham Heartlands and Solihull Trust) in 1979. As consultant Tony developed a chronic pain service with a consultant colleague. He also undertook regular ear, nose, and throat, and thoracic surgical sessions. He leaves Noreen and two children.
Choices about Cardiopulmonary Resuscitation in the Hospital
Authors: Susanna E. Bedell, Thomas L. Delbanco
Journal: New England Journal of Medicine (1984)

Abstract We studied the extent to which 82 private physicians and 75 house officers talked with hospitalized patients or their families (or both) about whether they would desire cardiopulmonary resuscitation if it became necessary. During the period of study (1981), 154 patients were resuscitated at our university teaching hospital. In 68 per cent of the cases, physicians had formed an opinion about the patient's attitude toward cardiopulmonary resuscitation. However, only 30 (19 per cent) of the patients had discussed resuscitation before the arrest with either their private physician or a house officer (or both); 51 (33 per cent) of the families were consulted. These percentages did not differ significantly according to the underlying disease, whether the patient was on the general wards or in the intensive-care unit, the physician's estimate of the probability of arrest, or the physician's level of training. Even the 151 physicians who believed that patients should participate in decisions about resuscitation, actually discussed the issue with their patients only rarely. We interviewed the 24 competent patients who survived cardiopulmonary resuscitation, to compare their actual attitudes about resuscitation with their physicians' opinions about their attitudes. The physician's opinion about a patient's desire for resuscitation correlated only weakly with the preference expressed by the patient. We suggest that physicians and patients consider the benefit of open discussion about cardiopulmonary resuscitation. (N Engl J Med 1984; 310:1089–93.)
Abstract 4809: Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.
Authors: Hannah E. Arem, Susan T. Mayne, Joshua Sampson, Harvey Risch, Rachael Z. Stolzenberg-Solomon
Journal: Cancer Research (2013)

Abstract Background: Some published studies on dietary fat and risk of pancreatic cancer suggest that dietary fat and specific fat sources may increase risk of pancreatic cancer. Methods: We examined the association between fat intake (measured by food frequency questionnaire) and pancreatic cancer risk among 111,416 participants in the PLCO Cancer Screening Trial using Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs). Results: There were 411 incident pancreatic cancer cases over the median 8.9 years of follow up. We observed an inverse association between saturated fat intake and pancreatic cancer risk comparing extreme quintiles (HR=0.64, 95% CI 0.46-0.88), but the association became weaker and non-significant when excluding individuals with &amp;lt;4 years of follow up to assess reverse causation HR=0.88 (95% CI 0.58-1.33). Total fat intake showed a similar pattern of association, while monounsaturated and polyunsaturated fat intakes and analysis by animal or plant source showed no association with risk. Conclusions: Despite more cases and longer follow up than most previous studies, our results do not suggest that higher fat consumption increases risk of pancreatic cancer. Lower fat intake in cases prior to diagnosis may reflect early manifestations of the disease (e.g. dyspepsia), and avoidance of fat which can exacerbate symptoms. Citation Format: Hannah E. Arem, Susan T. Mayne, Joshua Sampson, Harvey Risch, Rachael Z. Stolzenberg-Solomon. Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4809. doi:10.1158/1538-7445.AM2013-4809
962-66 Simultaneous Dobutamine Stress Echocardiography/MIBI-SPECT for Diagnosis of Coronary Artery Disease
Authors: Vitantonio Di Bello, Calogero Riccardo Bellina, Giuseppe Boni, Luigi Talarico, Federica Matteucci, Carmine Di Muro, Nicola Molea, Enrico Magagnini, Maria Teresa Caputo, Elena Lazzeri, Davide Giorgi, Romano Bianchi, Costantino Giusti
Journal: Journal of the American College of Cardiology (1995)
Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity
Authors: Frederico Pittella, Mingzhen Zhang, Yan Lee, Hyun J. Kim, Theofilus Tockary, Kensuke Osada, Takehiko Ishii, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka
Journal: Biomaterials (2011)