tbuckley/cabot-search huggingface dataset:
Efficacy and safety of ‘wet-wrap’ dressings as an intervention treatment in children with severe and/or refractory atopic dermatitis: a critical review of the literature
Authors: A.C.A. Devillers, A.P. Oranje
Journal: British Journal of Dermatology (2006)

Journal Article Efficacy and safety of ‘wet‐wrap’ dressings as an intervention treatment in children with severe and/or refractory atopic dermatitis: a critical review of the literature Get access A.C.A. Devillers, A.C.A. Devillers Department of Dermatology and Venereology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar A.P. Oranje A.P. Oranje Department of Dermatology and Venereology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, the Netherlands A.P. Oranje. E‐mail: a.p.oranje@erasmusmc.nl; a.oranje@inter.nl.net Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 154, Issue 4, 1 April 2006, Pages 579–585, https://doi.org/10.1111/j.1365-2133.2006.07157.x Published: 01 April 2006 Article history Accepted: 27 October 2005 Published: 01 April 2006
Anti-intermediate filament antibodies, antikeratin antibody, and antiperinuclear factor in rheumatoid arthritis and infectious mononucleosis.
Authors: P K Kataaha, S M Mortazavi-Milani, G Russell, E J Holborow
Journal: Annals of the Rheumatic Diseases (1985)

Sera from patients with rheumatoid arthritis (RA), patients with infectious mononucleosis (IM), and blood donors were tested by indirect immunofluorescence for the presence of antikeratin antibody (AKA), antibody to cytoskeletal intermediate filaments of prekeratin or vimentin type (AIFA) and antiperinuclear factor (APF). In 81.9% of the RA sera and 92.5% of the IM sera AIFA of IgM class was found at titres up to and in some cases exceeding 1/160. In blood donors the incidence of AIFA was 26%, at titres not exceeding 1/20. AKA and APF, always of IgG class, were found in 54.2% and 73.6% of rheumatoid sera. A weak correlation was found in RA between the incidence of AIFA and APF. AKA was not present in either IM or blood donor sera, and APF was found in only 2.5% and 3.2% of IM or blood donors respectively.
Control of the immune response to contact sensitizing chemicals by cutaneous antigen-presenting cells
Authors: P.A. BOTHAM, N.J. RATTRAY, S.T. WALSH, E.J. RILEY
Journal: British Journal of Dermatology (1987)

The fate of 2,4-dinitrochlorobenzene, a potent contact sensitizing chemical, and 2,4-dichloronitrobenzene, a non-sensitizer, was compared following their application to the skin of BALB/c mice. Although both chemicals were able to bind to protein in vitro and were capable of being absorbed across mouse skin in vivo, only 2,4-dinitrochlorobenzene was able to bind to cells in the skin and to induce the movement of these cells from the epidermis into the dermis and ultimately into the draining lymph nodes. The sensitization potential of a chemical may therefore be dependent on its ability to associate with and stimulate the efflux of cutaneous antigen-presenting cells.
Antibiotic Resistance and Transfer Factor in Salmonella, United States 1967
Authors: Steven A. Schroeder
Journal: JAMA (1968)

Four hundred Salmonella strains isolated during 1967 from clinical sources throughout the United States were examined for resistance to 11 antibiotics, and suitable strains were tested for resistance transfer factor (RTF). Only 89 (22%) of the strains were resistant to one or more of the antibiotics. Resistance was most common to streptomycin (14.2%), tetracycline (12.5%), and sulfathiazole (11.5%). None of the strains were resistant to chloramphenicol, nalidixic acid, or colistin sulfate. Resistance was significantly more common in strains of<i>Salmonella typhimurium</i>than in the other<i>Salmonella</i>serotypes. Of 52 multiply resistant strains, 41 (79%) demonstrated RTF. Comparison with previous studies suggests that no significant change in the incidence of resistant<i>Salmonella</i>has occurred during the past five years.
Psychopharmacology: A Biennial Critical Survey of the International Literature
Authors: Daniel P. van Kammen
Journal: JAMA (1983)

These two volumes are evidently the first of a biennial series on the state of the art in preclinical and clinical psychopharmacology. Many such books are presently appearing. Why might we need these two volumes?  I came away from reading these books with much enthusiasm and only a few disappointments. It speaks for the strength of the psychiatric departments of Professors Hippius (who holds the former chair of Emile Kraepelin in Munich) and Winokur (of the University of Iowa Medical College, Iowa City) that they have provided half of the chapters in part 2. I liked in particular the chapters on neuroleptics, opiates, antidepressants, the monoamine oxidase inhibitors, lithium, and the tranquilizers.  Part 1 is most informative for the clinical researcher for comparison of different drugs and schools of thought about mechanism of action. I found the discussion of the new developments in antidepressants, dementia treatment, anxiety, and neuroleptic and
Azithromycin or montelukast as inhaled corticosteroid–sparing agents in moderate-to-severe childhood asthma study
Authors: Robert C. Strunk, Leonard B. Bacharier, Brenda R. Phillips, Stanley J. Szefler, Robert S. Zeiger, Vernon M. Chinchilli, Fernando D. Martinez, Robert F. Lemanske, Lynn M. Taussig, David T. Mauger, Wayne J. Morgan, Christine A. Sorkness, Ian M. Paul, Theresa Guilbert, Marzena Krawiec, Ronina Covar, Gary Larsen
Journal: Journal of Allergy and Clinical Immunology (2008)
Tuberculous Brain Abscess and Toxoplasma Encephalitis in a Patient With the Acquired Immunodeficiency Syndrome
Authors: Margaret A. Fischl, Arthur E. Pitchenik, Thomas J. Spira
Journal: JAMA (1985)

INFECTIOUS diseases of the central nervous system among immunocompromised patients are not uncommon but rarely involve more than one pathogen.<sup>1</sup><i>Mycobacterium tuberculosis</i>is an infrequent cause of central nervous system infection among immunocompromised patients.<sup>2,3</sup>When seen, meningitis is by far the most common presentation. Occurrence of a tuberculous brain abscess is rare.<sup>4-8</sup> <i>Toxoplasma</i>encephalitis has been recognized as one of the more common central nervous system infections among patients with the acquired immunodeficiency syndrome (AIDS). Concomitant infections, although uncommon, may be an emerging problem. The present report summarizes our experience with a patient who had a tuberculous brain abscess and concomitant<i>Toxoplasma</i>encephalitis. <h3>Report of a Case</h3> A 22-year-old Haitian woman was admitted to the hospital with a nine-month history of fever, watery diarrhea, anorexia, and a 9.1-kg weight loss. A three-month history of tingling and progressive weakness of the left upper and lower extremities, with inability
Can This Patient Read and Understand Written Health Information?
Authors: Benjamin J. Powers, Jane V. Trinh, Hayden B. Bosworth
Journal: JAMA (2010)

Patients with limited literacy are at higher risk for poor health outcomes; however, physicians' perceptions are inaccurate for identifying these patients.To systematically review the accuracy of brief instruments for identifying patients with limited literacy.Search of the English-language literature from 1969 through February 2010 using PubMed, Psychinfo, and bibliographies of selected manuscripts for articles on health literacy, numeracy, reading ability, and reading skill.Prospective studies including adult patients 18 years or older that evaluated a brief instrument for identifying limited literacy in a health care setting compared with an accepted literacy reference standard.Studies were evaluated independently by 2 reviewers who each abstracted information and assigned an overall quality rating. Disagreements were adjudicated by a third reviewer.Ten studies using 6 different instruments met inclusion criteria. Among multi-item measures, the Newest Vital Sign (English) performed moderately well for identifying limited literacy based on 3 studies. Among the single-item questions, asking about a patient's use of a surrogate reader, confidence filling out medical forms, and self-rated reading ability performed moderately well in identifying patients with inadequate or marginal literacy. Asking a patient, "How confident are you in filling out medical forms by yourself?" is associated with a summary likelihood ratio (LR) for limited literacy of 5.0 (95% confidence interval [CI], 3.8-6.4) for an answer of "a little confident" or "not at all confident"; a summary LR of 2.2 (95% CI, 1.5-3.3) for "somewhat confident"; and a summary LR of 0.44 (95% CI, 0.24-0.82) for "quite a bit" or "extremely confident."Several single-item questions, including use of a surrogate reader and confidence with medical forms, were moderately effective for quickly identifying patients with limited literacy.
PET/CT Images of Bilateral Diffuse Intraglomerular Metastasis of Malignant Melanoma
Authors: Handan Tokmak, Yasemin Özlük, Nil Molinas Mandel
Journal: Clinical Nuclear Medicine (2013)

Intraglomerular metastasis is a very rare condition with an underlying cause that is not yet well understood. We present the 18F-FDG PET/CT images of histologically proven intraglomerular metastases from newly diagnosed malignant melanoma with positive sentinel lymph node metastases. During the initial diagnostic evaluation period, the patient also had a sudden increased serum creatinine level. FDG PET/CT demonstrated diffuse glomerular FDG uptake unlike typical physiologic pelvicaliceal activity. Renal biopsy revealed diffuse crescentic lesions containing metastatic melanoma cells.
Multiple Target Involvement in Pseudohypoaldosteronism
Authors: Samuel Vaisrub
Journal: JAMA (1979)

Despite two decades of its recorded history,<sup>1</sup>pseudohypoaldosteronism is not listed in standard medical dictionaries among their more than 250 entries prefixed by "pseudo." The omission is the more surprising because at least 40 cases of this disorder have been reported. Clearly, dictionaries may be even less successful than standard texts in keeping abreast of the times. "Pseudo" has negative connotations. It denotes deceptive resemblances, pretended identities, false credentials. However, with the first report of pseudohypoparathyroidism by Albright in 1942, the prefix acquired a positive ring. It now designated an entity that did not merely bear a false resemblance to hypoparathyroidism but also had a definite identity of its own. Its symptoms and signs were caused not by deficiency of parathyroid hormone, but by unresponsiveness of the renal tubules to the hormonal action at the receptor or postreceptor level. With the discovery that target organ unresponsiveness can mimic the
Two patients with metastasis of cancer to other neoplasm: A thyroid carcinoma metastatic to a lung carcinoma and a gastric carcinoma metastatic to a thyroid adenoma
Authors: Akitaka Nonomura, Yuji Mizukami, Junzo Shimizu, Yoh Watanabe, Ryoichi Kamimura, Tsutomu Takashima
Journal: Endocrine Pathology (1994)
A CASE OF PERIPHERAL NERVE SYPHILIS.
Authors: JULIUS GRINKER
Journal: JAMA (1905)

That the peripheral nerves, both cranial and spinal, frequently become affected in the course of cerebrospinal syphilis, is every-day experience. Disease of peripheral nerves or nerve-roots without co-existent syphilis of the central nervous system, is rather unusual. Of all cranial nerves the trigeminus is most often affected singly by the specific process. This may occur as part of a periostitic process in the foramina of exit; at the optic foramen, foramen ovale and foramen rotundum; or as a result of destructive processes in the nucleus by hemorrhage, softening, sclerosis or tumor. Isolated disease of the trigeminus, however, is exceedingly rare. The rule is for other nerves to be involved along with the trigeminus in the following order: Optic, facial, oculomotor, abducens, auditory, olfactory, trochlear. The facial, acousticus and motor nerves of the eye are frequently affected together and constitute part of a basal meningitis. The clinical phenomena of peripheral nerve-syphilis
Book Review Polio: An American Story By David M. Oshinsky. 342 pp., illustrated. New York, Oxford University Press, 2005. $30. 0-19-515294-8 Living with Polio: The Epidemic and Its Survivors By Daniel J. Wilson. 300 pp., illustrated. Chicago, University of Chicago Press, 2005. $29. 0-226-90103-3
Authors: John F. Modlin
Journal: New England Journal of Medicine (2005)
Body surface potential distribution following the production of right bundle branch block in dogs. Effects of breakthrough and right ventricular excitation on the body surface potentials.
Authors: J Sugenoya, S Sugiyama, M Wada, N Niimi, H Oguri
Journal: Circulation (1977)

Right bundle branch block (RBBB) was produced in five dogs by incising the main right bundle branch. Body surface isopotential maps of each of these dogs were obtained from 85 thoracic electrocardiograms using a mini-computer technique. In addition, the epicardial activaton process was obtained from the same dog, and were correlated with the map pattern. Following the incision, the following characteristic changes in the map pattern occurred: The ventricular activation was prolonged in RBBB as compared with normal. During the early stage of ventricular excitation, the maximum was shifted leftward due to the activation wavefronts in the left ventricle in contrast to the double septal activation in the control. A localized lower potential area (a concavity) which appears in the middle stage of activation within the anterior positivity as an initial representation of breakthrough was also shifted left-and-downward and delayed in appearance. The sudden change in the potential distribution subsequently observed occurred quite differently. The terminal excitation was characterized by the maximum occurring over the right chest in RBBB in contrast to the left chest in control. These changes in the pattern of the potential distribution were compatible with the changes in the ventricular excitation process. This result may be applied to human RBBB map interpretation.
Quantification of coronary arterial narrowing at necropsy in acute transmural myocardial infarction. Analysis and comparison of findings in 27 patients and 22 controls.
Authors: W C Roberts, A A Jones
Journal: Circulation (1980)

We quantitatively analyzed the degree and extent of coronary arterial narrowing by atherosclerotic plaques in the entire length of each of the four major coronary arteries in 27 necropsy patients with transmural acute myocardial infarction (AMI) and compared the findings with those in 22 control subjects. Of the 1403 5-mm segments examined in the 27 AMI patients, 484 (34%; controls 3%) were 76-100% narrowed in cross-sectional area by atherosclerotic plaques, 528 (38%; controls 25%) were 51-75% narrowed, 319 (23%; controls 44%) were 26-50% narrowed, and only 72 segments (5%; controls 28%) were less than or equal to 25% narrowed. The amount of severe (greater than 75%) narrowing of the right, left anterior descending and left circumflex coronary arteries by atherosclerotic plaques was similar, as was the amount of severe narrowing in the distal and proximal halves of these three arteries. The number of severely narrowed 5-mm segments did not correlate significantly with the patient's age at death, the presence or absence of a history of angina pectoris or healed myocardial infarction, or with heart weight. The men, however, had a significantly greater number of severely narrowed 5-mm segments of coronary artery than the women (p less than 0.05), and the patients with associated transmural left ventricular scars had significantly more severely narrowed segments than did patients without transmural scars.
Scintigraphy in Severe Tenosynovitis of the Tibialis Posterior Tendon
Authors: SIRI KANNANGARA, WARWICK BRUCE, SIMON R. HUTABARAT, MICHAEL MAGEE, HANS VAN DER WALL
Journal: Clinical Nuclear Medicine (1999)

A 48-year-old woman had a 2-week history of increasingly severe right posterior ankle pain after she began a walking program 4 weeks earlier. The results of plain radiography were reported as normal. Achilles tendonitis was suspected, with the possibility of an early calcaneal stress fracture. Bone scintigraphy revealed changes consistent with severe tibialis posterior tenosynovitis. Because of the intensity of changes in the medial malleolus, an infective cause was considered possible. Surgical exploration and biopsy revealed a severe fibrinous tenosynovitis and associated periostitis of the medial malleolus. Culture of biopsy material grew no organisms. Because no other cause could be identified, the inflammatory response was ascribed to overuse injury. The patient was treated with a corticosteroid injection into the tendon sheath, with good effect.
Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.
Authors: K Chihara, Y Kato, K Maeda, S Matsukura, H Imura
Journal: Journal of Clinical Investigation (1976)

The effect of cyproheptadine on plasma growth hormone and cortisol levels was studied in seven male volunteers with polygraphic sleep monitoring. Sleep-related growth hormone release was completely inhibited in three of the seven normal subjects by the intravenous infusion of cyproheptadine (5 mg) which was started at the onset of sleep. In the other four, growth hormone release during sleep was significantly decreased or delayed by cyproheptadine when the drug infusion was started at 7:00 p.m., 1-2 h before the onset of sleep. The usual increase in plasma cortisol in the early morning was completely suppressed in all five subjects given cyproheptadine infusions from 4:00 to 7:00 a.m. The intravenous infusion of cyproheptadine increased slow wave sleep, although the time from sleep onset to the first occurrence of slow wave sleep was not affected. In contrast, rapid eye movement sleep was significantly decreased by cyproheptadine. These results suggest that cyproheptadine inhibits growth hormone and ACTH secretion during sleep in man, possibly by antagonizing serotoninergic mechanisms although other actions of the drug are not ruled out.
175 Years Old: Some Anniversary Thoughts and a New Look
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1987)

With the first issue of this new year, the Journal celebrates its 175th anniversary. In January of 1812 Dr. John Collins Warren and his Boston friends launched the New England Journal of Medicine and Surgery and the Collateral Branches of Science. Although not the first medical periodical in the Western world, it was destined to become the oldest in continuous existence, antedating all the other well-known journals now on the scene.At first it was published quarterly, but then in 1828, after the purchase and incorporation of a rival new weekly newspaper called the Boston Medical Intelligencer, it . . .
Arthritis in the Mediterranean Theater of Operations
Authors: Charles L. Short
Journal: New England Journal of Medicine (1947)

IN ADDITION to the various types of joint disease described in the two previous papers,1 , 2 infectious and miscellaneous forms of arthritis were encountered among United States Army personnel in the Mediterranean Theater.Arthritis Associated with Bacillary DysenteryThe arthritis associated with bacillary dysentery, although infrequently diagnosed, seemed of particular interest on account of an unusual symptom-complex that was encountered, especially in the region of Oran, Algeria, in the warmer months of 1943. This syndrome, which consisted in arthritis with conjunctivitis or urethritis, or both, and which has been mentioned in reports in the literature, has already been described by Lieutenant . . .
Crises in Congenital Spherocytic Anaemia (Acholuric Jaundice)
Authors: J. L. Emery, D. W. Lemmon
Journal: BMJ (1954)

_73to a similar conclusion.Ovarian tumour, constriction ring, or breech or face presentation were not observed, although Freeth found one of each abnormality.A maternal mortality of 2% and a foetal loss of 28% are similar to Freeth's figures.In the last 25 cases reviewed the total foetal loss was only 8% and all the mothers survived.Reference to Table VII demonstrates the progressive im- provement in the maternal mortality since 1928.Analysis of the deaths 'in Miller's series suggests that the reduction TABLE VII.-Review of Earlier SeriesINo of Mater-Foetal Minimal No. of
Histoplasmosis follow-up
Authors: Phil Gunby
Journal: JAMA (1980)

Indianapolis' histoplasmosis outbreak appears to be over, but Indiana University School of Medicine investigators are urging physicians to be alert for long-term sequelae. The 1978-1979 outbreak claimed 15 lives (<i>JAMA</i>[MEDICAL NEWS] 242:1010, 1979). Before it subsided, 435 histoplasmosis cases were confirmed serologically. The actual total may be much higher, says L. Joseph Wheat, MD, because persons with few or no symptoms were unlikely to see a physician. Wheat is an assistant professor of medicine, Division of Infectious Diseases, at the medical school, which cooperated with local, state, and federal officials in the investigation. He and co-workers are reminding area physicians that possible sequelae of histoplasmosis include fibrous mediastinitis, constrictive pericarditis, chronic obstructive, fibrotic, or cavitary lung disease, presumed ocular histoplasmosis (<i>JAMA</i>[MEDICAL NEWS] 243:626-627, 1980), and, of course, recurrent histoplasmosis, which may be caused by fluctuations in the infected person's immunity to<i>Histoplasma capsulatum</i>. The source of the Indianapolis
Phase 1 and 2 Studies Demonstrate the Safety and Efficacy of Intraprostatic Injection of PRX302 for the Targeted Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
Authors: Samuel R. Denmeade, Blair Egerdie, Gary Steinhoff, Rosemina Merchant, Ralph Abi-Habib, Peter Pommerville
Journal: European Urology (2010)
Association of Parathyroid Tumors in Multiple Endocrine Neoplasia Type 1 with Loss of Alleles on Chromosome 11
Authors: R V Thakker, P Bouloux, C Wooding, K Chotai, P M Broad, N K Spurr, G M Besser, J L O'Riordan
Journal: New England Journal of Medicine (1989)

Familial multiple endocrine neoplasia type 1 (MEN-1) is an autosomal dominant disorder characterized by the combined occurrence of tumors of the parathyroid glands, the pancreas, and the pituitary gland. Pancreatic tumors have previously been shown to be associated with the loss of alleles on chromosome 11; we therefore looked for similar genetic alterations in specimens of parathyroid tumors, which are the most common feature of MEN-1. We obtained parathyroid tumors and peripheral-blood leukocytes from six patients with MEN-1; 18 cloned human DNA sequences from chromosome 11 were then used to identify restriction-fragment-length polymorphisms. A loss of heterozygosity was detected in parathyroid tumors from three of the six patients with MEN-1; this finding demonstrated that allelic deletions on chromosome 11 are involved in the monoclonal development of parathyroid tumors in patients with MEN-1. In addition, studies of three affected families (with 17 affected members and 51 unaffected members) established linkage with the oncogene INT2 (peak lod score, 3.30, at 0 percent recombination); the MEN-1 gene was thus mapped to the pericentromeric region of the long arm of chromosome 11 (11q13). Our location of the MEN-1 gene at 11q13 is close to the location previously reported. We conclude that a single inherited locus on chromosome 11, band q13, causes MEN-1 and that the monoclonal development of parathyroid and pancreatic tumors in patients with MEN-1 involves similar allelic deletions on chromosome 11.