Association between Body Mass Index and Diabetes and Hepatocellular Carcinoma
Authors: Kazuki Ikeda, Hiroyuki Marusawa, Tsutomu Chiba
Journal: Annals of Internal Medicine (2008)

Letters15 January 2008Association between Body Mass Index and Diabetes and Hepatocellular CarcinomaKazuki Ikeda, MD, Hiroyuki Marusawa, MD, PhD, and Tsutomu Chiba, MD, PhDKazuki Ikeda, MDFrom Kyoto University, Kyoto, Japan 606-8507.Search for more papers by this author, Hiroyuki Marusawa, MD, PhDFrom Kyoto University, Kyoto, Japan 606-8507.Search for more papers by this author, and Tsutomu Chiba, MD, PhDFrom Kyoto University, Kyoto, Japan 606-8507.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-2-200801150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Drs. Loomba and Ghany for their comments. As they pointed out, obesity is widely recognized as a significant risk factor for many types of human cancer, including HCC (1). In our paper, we prospectively analyzed the various clinical factors, including anti-HBc positivity, smoking, and alcohol intake, as risks for the occurrence of HCC in Japanese patients with hepatitis C virus (HCV) infection.We found that the incidence of HCC in patients with a BMI of 30 kg/m2 did not significantly differ from that of patients with a BMI of 25 kg/m2 (16.7% vs. 22.1%, respectively; P = ...References1. Caldwell SH, Crespo DM, Kang HS, Al-Osaimi AM. Obesity and hepatocellular carcinoma. Gastroenterology. 2004;127:S97-103. [PMID: 15508109] CrossrefMedlineGoogle Scholar2. McTigue KM, Garrett JM, Popkin BM. The natural history of the development of obesity in a cohort of young U.S. adults between 1981 and 1998. Ann Intern Med. 2002;136:857-64. [PMID: 12069559] LinkGoogle Scholar3. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625-38. [PMID: 12711737] CrossrefMedlineGoogle Scholar4. El-Serag HB, Richardson PA, Everhart JE. The role of diabetes in hepatocellular carcinoma: a case–control study among United States Veterans. Am J Gastroenterol. 2001;96:2462-7. [PMID: 11513191] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Kazuki Ikeda, MD; Hiroyuki Marusawa, MD, PhD; Tsutomu Chiba, MD, PhDAffiliations: From Kyoto University, Kyoto, Japan 606-8507.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Natural History of the Development of Obesity in a Cohort of Young U.S. Adults between 1981 and 1998 Kathleen M. McTigue , Joanne M. Garrett , and Barry M. Popkin Antibody to Hepatitis B Core Antigen and Risk for Hepatitis C–Related Hepatocellular Carcinoma Kazuki Ikeda , Hiroyuki Marusawa , Yukio Osaki , Takefumi Nakamura , Naoto Kitajima , Yukitaka Yamashita , Masatoshi Kudo , Tosiya Sato , and Tsutomu Chiba Metrics 15 January 2008Volume 148, Issue 2Page: 167KeywordsBody mass indexCancer risk factorsChronic liver diseaseInfectious hepatitisInsulinMedical risk factorsObesityOverweightProspective studiesRelative risk ePublished: 15 January 2008 Issue Published: 15 January 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...