tbuckley/cabot-search huggingface dataset:
Topical cyclosporin and T lymphocytes in keloid scars
Authors: Janet I. Duncan, A.W. Thomson, I.F.K. Muir
Journal: British Journal of Dermatology (1991)

Journal Article Topical cyclosporin and T lymphocytes in keloid scars Get access Janet I. Duncan, Janet I. Duncan Immunopathology Laboratory. Department of Pathology, Foresterhill, Aberdeen AB9 2ZD, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.W. Thomson, A.W. Thomson Immunopathology Laboratory. Department of Pathology, Foresterhill, Aberdeen AB9 2ZD, U.K. Search for other works by this author on: Oxford Academic Google Scholar I.F.K. Muir I.F.K. Muir Department of Surgery, University of Aberdeen Medical School, Foresterhill, Aberdeen AB9 2ZD, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 1, 1 January 1991, Page 109, https://doi.org/10.1111/j.1365-2133.1991.tb03293.x Published: 01 January 1991
Causes of failure in antibiotic treatment.
Authors: L P Garrod
Journal: BMJ (1972)

From a study of the organization of a national clinical trial on the management of early cancer of the breast in women there appear to be overwhelming advantages in studying large numbers of patients.To this end centres abroad have been encouraged to join.All the evidence at present suggests that it is feasible to organize a study on this scale, that the documentation and follow-up are accurate, and that the enthusiasm of the participants can be successfully fostered and maintained.
A63: Treatment of Arthritis in Animal Models of the Mucopolysaccharidoses Using a Novel Anti-Inflammatory Drug, Pentosan Polysulfate
Authors: Calogera Simonaro, Michael Frohbergh, Yi Ge, Fanli Meng, Edward Schuchman
Journal: Arthritis & Rheumatology (2014)

Background/Purpose:

The mucopolysaccharidoses (MPS) comprise a group of 11 lysosomal storage disorders (LSDs) due to inherited deficiencies of glycosaminoglycan (GAG) degrading enzymes. Naturally occurring animal models exist for most of these disorders, providing excellent systems in which to study disease pathogenesis and treatment. We have previously shown that GAG storage in MPS leads to activation of the TLR4/TNF-alpha inflammatory pathway, and that inflammation is a major contributor to the degenerative cartilage disease occurring in MPS patients. The pattern of inflammatory changes in MPS closely resembles that occurring in arthritis, and the MPS animals also represent excellent, naturally occurring genetic models of arthritis. Various treatment approaches have been investigated for MPS, and we recently identified one FDA-approved drug, pentosan polysulfate (PPS), that resulted in remarkable clinical improvements in a rat model of MPS type VI (Schuchman et al., PLoS One, 2013).



Methods:

In our previous work we reported the effects of daily oral PPS treatment in MPS VI rats, and here we compare these effects with weekly subcutaneous (subQ) injections. Four groups of MPS VI rats were treated with weekly subQ PPS at human equivalent doses of 1, 2 and 4 mg/kg, and with a combination of 2 mg/kg PPS and 1 mg/kg enzyme replacement therapy (ERT; Naglazyme®).



Results:

The most efficacious subQ PPS dose was 2 mg/kg. Among the four groups of treated rats the best results were found in animals treated with a combination of PPS and ERT. Treatment of all MPS VI rats with weekly subQ PPS for up to 6 months was safe.



Conclusion:

We propose that weekly subQ injections of PPS will be efficacious and safe in MPS patients, and a phase 1/2 clinical study is planned. We also propose that PPS could be effective in arthritis, and might provide a cost-effective, safe alternative to existing TNF-alpha drugs.
PCI OR CORONARY ARTERY BYPASS GRAFT: IMPLICATIONS IN END–STAGE RENAL DISEASE PATIENTS
Authors: Salman Jamaluddin Bandeali, Moaz M. Choudhary, Salim Virani, Hani Jneid, Shama A. Sewani, Ahmed Waqas, Sukhdeep Basra, Peter Tsai, Neal Kleiman, Joseph Coselli, Nasser Lakkis, Mahboob Alam
Journal: Journal of the American College of Cardiology (2013)
Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia
Authors: Marie-Laure Michel, Alexandre Castro Keller, Christophe Paget, Masakazu Fujio, François Trottein, Paul B. Savage, Chi-Huey Wong, Elke Schneider, Michel Dy, Maria C. Leite-de-Moraes
Journal: The Journal of Experimental Medicine (2007)

Invariant natural killer T (iNKT) cells are an important source of both T helper type 1 (Th1) and Th2 cytokines, through which they can exert beneficial, as well as deleterious, effects in a variety of inflammatory diseases. This functional heterogeneity raises the question of how far phenotypically distinct subpopulations are responsible for such contrasting activities. In this study, we identify a particular set of iNKT cells that lack the NK1.1 marker (NK1.1(neg)) and secrete high amounts of interleukin (IL)-17 and low levels of interferon (IFN)-gamma and IL-4. NK1.1(neg) iNKT cells produce IL-17 upon synthetic (alpha-galactosylceramide [alpha-GalCer] or PBS-57), as well as natural (lipopolysaccharides or glycolipids derived from Sphingomonas wittichii and Borrelia burgdorferi), ligand stimulation. NK1.1(neg) iNKT cells are more frequent in the lung, which is consistent with a role in the natural immunity to inhaled antigens. Indeed, airway neutrophilia induced by alpha-GalCer or lipopolysaccharide instillation was significantly reduced in iNKT-cell-deficient Jalpha18(-/-) mice, which produced significantly less IL-17 in their bronchoalveolar lavage fluid than wild-type controls. Furthermore, airway neutrophilia was abolished by a single treatment with neutralizing monoclonal antibody against IL-17 before alpha-GalCer administration. Collectively, our findings reveal that NK1.1(neg) iNKT lymphocytes represent a new population of IL-17-producing cells that can contribute to neutrophil recruitment through preferential IL-17 secretion.
Response to Schade
Authors: Eugenio Cersosimo
Journal: Diabetes Care (2003)

In the editorial published in the November issue of Diabetes Care , entitled “To Pump or Not to Pump” (1), Dr. David Schade provides an excellent review of the recent history of the “intensive insulin therapy” approach for the management of type 1 diabetic patients and the gradual development of continuous subcutaneous insulin infusion utilizing an external insulin infusion pump (CSII). Surprisingly, despite the overwhelming evidence that CSII is superior to some multiple insulin injection (MDI) programs, …
Prediction of 1-Year Survival After Thrombolysis for Acute Myocardial Infarction in the Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries Trial
Authors: Robert M. Califf, Karen S. Pieper, Kerry L. Lee, Frans Van de Werf, R. John Simes, Paul W. Armstrong, Eric J. Topol
Journal: Circulation (2000)

Background —When a patient survives thrombolysis for acute myocardial infarction, little information from large studies exists from which to estimate prognosis during follow-up visits. Methods and Results —Baseline, in-hospital, and later survival data were collected from 41 021 patients enrolled in Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries, a randomized trial of 4 thrombolytic-heparin regimens with standard aspirin and β-blockade. Cox proportional hazards models were developed to predict 1-year survival in 30-day survivors (n=37 869) from baseline clinical and ECG factors and in-hospital factors; a combined model then was developed (C-index 0.800). The model was simplified into a nomogram to predict individual outcomes (C-index 0.754). Factors reflecting demographics (advanced age, lighter weight), larger infarctions (higher Killip class, lower blood pressure, faster heart rate, longer QRS duration), cardiac risk (smoking, hypertension, prior cerebrovascular disease), and arrhythmia were important predictors of death between 30 days and 1 year. Black race was associated with a substantial increase in risk after considering other factors. Revascularization was associated with reduced risk between 30 days and 1 year. Conclusions —When evaluating a patient who has survived acute infarction treated with thrombolysis, clinicians can estimate the likelihood of survival from factors easily measured during admission. Although many risk factors clearly relate to age, left ventricular dysfunction, or clinical instability, black race is an unexplained risk factor requiring further examination.
Letter: Hypoglycaemia associated with intrathoracic mesothelioma.
Authors: J S Leung, S T Tang
Journal: BMJ (1974)

chlamydial infection, thus making laboratory diagnosis difficult, but will not eradicate the disease.Neomycin is not active against chlamydia, 'but is reasonably effective against bacterial infections and should be the initial antibiotic of choice until swabs can be taken and examined for chlamydia.The persistence of conjunctivitis after neomycin should lead the clinician to investigate the possibility of chlamydial infection in both the infant and its parents.-Weare, etc.,
Olives-Craving in Iron Deficiency Anemia
Authors: PRADEEP CHANDRA
Journal: Annals of Internal Medicine (1973)

Letters1 June 1973Olives-Craving in Iron Deficiency AnemiaPRADEEP CHANDRA, M.D., FRED ROSNER, M.D., F.A.C.P.PRADEEP CHANDRA, M.D.Search for more papers by this author, FRED ROSNER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-6-973 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have recently seen a 42-year-old woman with iron deficiency anemia and an intense craving for olives that was relieved by oral iron therapy.The patient gave a history of menorrhagia of many years' duration. Four months before hospitalization she began to develop an intense craving for olives. She ate approximately five to seven jars of green olives weekly. The urge to eat olives was so intense that every afternoon she would leave her place of employment an hour early to go to the store to purchase olives.The patient had generalized pallor; she had no lymphadenopathy,...References1. CROSBY W: Food pica and iron deficiency (editorial). Arch Intern Med 127:960-961, 1971 CrossrefMedlineGoogle Scholar2. COLTMAN C: Pagophagia and iron lack. JAMA 207:513-519, 1969 CrossrefMedlineGoogle Scholar3. REYNOLDSBINDERMILLER RHM: Pagophagia and iron deficiency anemia. Ann Intern Med 69:435-440, 1968 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PRADEEP CHANDRA, M.D.; FRED ROSNER, M.D., F.A.C.P.Affiliations: Queens Hospital Center Affiliation of the Long Island Jewish-Hillside Medical Center Jamaica, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVincent van Gogh (1853–90): the plumbic artistPica, iron deficiency, and the medical historyPica: Symptom or Eating Disorder? A Historical Assessment 1 June 1973Volume 78, Issue 6Page: 973-974KeywordsHospitalizationsIron deficiency anemia ePublished: 1 December 2008 Issue Published: 1 June 1973 PDF downloadLoading ...
Erythromycin Derivative Improves Gastric Emptying and Insulin Requirement in Diabetic Patients With Gastroparesis
Authors: Masataka Ishii, Teruo Nakamura, Fukio Kasai, Tsuneharu Baba, Kazuo Takebe
Journal: Diabetes Care (1997)

OBJECTIVE To evaluate the effect of the erythromycin derivative EM523L on gastric emptying and postprandial insulin requirement in insulin-dependent diabetic patients with severe gastroparesis. RESEARCH DESIGN AND METHODS In six IDDM patients with severe gastroparesis (two men and four women, mean age 44.5 years [range 36–53]), the insulin infusion pattern during feedback control with an artificial endocrine pancreas device (Biostator) after intake of a test meal, the retention rate of residual isotope (99mTc-labelled Sn-colloid) in the stomach, and the time-concentration curve of plasma acetaminophen as the marker for liquid emptying were studied with EM523L or a control placebo RESULTS Time courses of insulin infusion rates peaked within 120 min after intake of the test meal in the EM523L phase, whereas no apparent peak rates were observed in the control phase. The total amount of insulin required in the first 90 min postprandial was significantly greater in the EM523L phase than in the control phase. EM523L significantly decreased the residual isotope ratio in the stomach at ≥50 min postprandial and increased the plasma acetaminophen concentrations at 30–120 min postprandial, compared with respective values in the control phase. CONCLUSIONS Preliminary results obtained from a small number of patients suggest that EM523L or erythromycin analogs, which have agonistic activity to motilin receptors as well as no antibacterial effect, may be useful to accelerate gastric emptying and improve insulin requirement patterns, thereby establishing more stable glycemic control.
Act now to prevent re-emergence of congenital rubella
Authors: P. A. Tookey, H. Bedford, C. S. Peckham
Journal: BMJ (2013)

Recent measles outbreaks highlight the potential for the re-emergence of rubella.1 Earlier UK rubella immunisation policy means that adult men could help sustain the spread of infection.

The schoolgirl immunisation programme was introduced in 1970 and later extended to susceptible women. Men born in the 1960s and 1970s never received a rubella vaccine, and those who escaped infection in childhood have had little exposure …
Fatal Asthma Attack After Inhaling Sulfur Fumes
Authors: Albert L. Huber
Journal: JAMA (1991)

To the Editor.  —We recently studied the circumstances surrounding the sudden death of an apparently healthy woman with asthma.  The patient was an active 76-year-old homemaker who was taking 40 mg of prednisone on alternate mornings and regularly using a flunisolide inhaler. She and her family regarded her as being in good health and symptom-free, although her most recent 1-second forced expiratory volume was less than 1L. Several minutes before her death, a derusting agent containing sulfite, Super Iron-out, had been put in her dishwasher in an effort to open a clogged drain. The machine was run for a few minutes. When she opened the dishwasher to check the results, offensive hot steamy vapors emerged. She gasped and immediately began to wheeze. She attempted to use her bronchodilator, but severe wheezing continued and she died within a few minutes. An autopsy done after embalming revealed mild to moderate coronary artery
Reports show management of CHD has improved
Authors: Susan Mayor
Journal: BMJ (2004)

The NHS in England has significantly improved the management of coronary heart disease (CHD) but has made less progress in preventing the disease, independent reviews of four geographical areas say.

The reviews assessed how far the NHS in each of the four areas—Croydon in south London, Plymouth in Devon, west Suffolk, and Hambleton and Richmondshire in Yorkshire—had progressed towards implementing the standards set out in the national service framework for coronary heart disease, published in March 2000 ( BMJ 2000;320: …
Blood Groups, Haemoglobins, and Thalassaemia in Turks and Eti-Turks
Authors: M. Aksoy, E. W. Ikin, A. E. Mourant, H. Lehmann
Journal: BMJ (1958)

The results of a number of surveys 9f the ABO blood groups of the Turkish population have been published.We do not, however, know of any observations hitherto published on the other blood-group systems.There have been numerous previous publications on thalass- aemia in the Turkish population, but the only published work on haemoglobins (apart from isolated cases of sickling) has been that carried out by two of the present authors and their collaborators.
Abstract 3872: A lineage-selective transcriptional pathway linking lung differentiation and cancer metastasis.
Authors: William K.C. Cheung, Minghui Zhao, Zongzhi Liu, Paul D. Cao, Laura E. Stevens, Thomas F. Westbrook, Don X. Nguyen
Journal: Cancer Research (2013)

Abstract Lung cancer is the leading cause of cancer-related deaths worldwide. This poor prognosis is due to the rapid metastatic progression of this disease, yet the mechanisms that govern lung cancer dissemination and colonization are unclear. Through an integrated approach, we identified an alveolar cell-selective gene signature that stratifies lung adenocarcinoma (ADC) into molecular subtypes of distinct prognosis and differentiation states. This transcriptional program is regulated in part by the cell fate transcription factors, GATA6 and HOPX, which are normally required for proper alveolar differentiation. In an experimental model, suppression of GATA6 and HOPX cooperatively enhances metastatic competence of lung ADC cells. Whole genome RNA sequencing reveals that this transcriptional network can modulate specific target genes and pathways involved in airway epithelial differentiation and invasion. Our findings identify a novel cell lineage molecular program whose perturbation enhances lung cancer metastasis. Citation Format: William K.C. Cheung, Minghui Zhao, Zongzhi Liu, Paul D. Cao, Laura E. Stevens, Thomas F. Westbrook, Don X. Nguyen. A lineage-selective transcriptional pathway linking lung differentiation and cancer metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3872. doi:10.1158/1538-7445.AM2013-3872
STEVSENS-JOHNSON SYNDROME ASSOCIATED WITH MYCOPLASMA PNEUMONILAE INFECTION
Authors: H. CANNELL, GILLAN M. CHURCHER, G. A. MILTON-THOMPSON
Journal: British Journal of Dermatology (1969)

Journal Article STEVSENS‐JOHNSON SYNDROME ASSOCIATED WITH MYCOPLASMA PNEUMONILAE INFECTION Get access H. CANNELL, H. CANNELL Royal Naval Hospital, Plymonth and Public Health Laboratory, Plymonth Search for other works by this author on: Oxford Academic Google Scholar GILLAN M. CHURCHER, GILLAN M. CHURCHER Royal Naval Hospital, Plymonth and Public Health Laboratory, Plymonth Search for other works by this author on: Oxford Academic Google Scholar G. A. MILTON‐THOMPSON G. A. MILTON‐THOMPSON Royal Naval Hospital, Plymonth and Public Health Laboratory, Plymonth Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 3, 1 March 1969, Pages 196–199, https://doi.org/10.1111/j.1365-2133.1969.tb16006.x Published: 01 March 1969 Article history Accepted: 29 August 1968 Published: 01 March 1969
A CASE OF ACROMEGALY PRESENTING CERTAIN FEATURES OF UNUSUAL INTEREST.
Authors: CHARLES LYMAN GREENE
Journal: JAMA (1901)

In 1886 acromegaly was first introduced to the medical world, through the report of Marie, the name having been applied by him to a disease characterized by a progressive enlargement or overgrowth of certain portions of the body, all tissue being more or less involved, and the hands, feet and face being the earlier and chief seats of the morbid change. There can be no doubt concerning the close relation of acromegaly to giantism; indeed, it may be regarded as a sort of localized giantism, due to certain limitations in the pathologic seat and process, or to the age at which the disease begins. Acromegaly is so strikingly objective in its symptomatology that one finds it difficult to explain how it could have been disregarded for so many centuries. Up to 1891 only 37 cases had been reported, yet in 1893 the number had reached 83; in 1898, 218 had
Genetic analysis of the K-rev-1 transformation-suppressor gene.
Authors: H Kitayama, T Matsuzaki, Y Sugimoto, Y Ikawa, M Noda
Journal: Environmental Health Perspectives (1991)

Flat revertants with reduced malignancy in vivo can be isolated from Kirsten sarcoma virus-transformed NIH 3T3 cells (DT line) following transfection with a normal human fibroblast cDNA expression library. We have recovered from one such revertant a 1.8-kb cDNA clone, K-rev-1, that exhibits an activity of inducing flat revertants at certain frequencies (2-5% of total transfectants) when transfected into DT cells. The K-rev-1 cDNA has the capacity to encode a protein with a calculated molecular weight of 21,000, having strong structural similarity to ras proteins (approximately 50% homology), especially in their guanosine triphosphate/guanosine diphosphate-binding, effector-binding, and membrane-attachment domains. Toward understanding the mechanism of action of K-rev-1 protein, we constructed a series of point mutants of K-rev-1 cDNA and tested their biological activities. Substitutions of the amino acid residues in the putative guanine nucleotide-binding regions (Asp17 and Asn116), in the putative effector-binding domain (residue 38), at the putative acylation site (Cys181), and at the unique Thr61 all decreased the transformation-suppressor activity. On the other hand, substitutions including Gly12 to Val12, Ala59 to Thr59, and Gln63 to Glu63 were found to significantly increase the transformation-suppressor activity of K-rev-1. These findings are consistent with the idea that K-rev-1 protein is regulated like many other G-proteins by guanine triphosphate/guanine diphosphate-exchange mechanism probably in response to certain negative growth-regulatory signals.
Postponement of Death-Reply
Authors: David P. Phillips
Journal: JAMA (1990)

In Reply.—  We appreciate Dr Man's providing evidence that supports our statistical findings on the postponement of death. These insights into Chinese cultural practices should prove valuable in generating additional lines of research. We should perhaps note one small inaccuracy in Dr Man's letter; we did not in fact restrict our computerized data set to San Diego Chinese but examined all deaths among Chinese throughout California from 1960 through 1984. We agree with Dr Man that a study of rural China would have been preferable, but computerized data on this area are not available, as far as we know.
Arterial and Venous Thrombosis Is Not Associated With the 4G/5G Polymorphism in the Promoter of the Plasminogen Activator Inhibitor Gene in a Large Cohort of US Men
Authors: Paul M. Ridker, Charles H. Hennekens, Klaus Lindpaintner, Meir J. Stampfer, Joseph P. Miletich
Journal: Circulation (1997)

Background The 4G allele of the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor (PAI-1) gene is associated with increased PAI-1 activity. In a small group of young Swedish men, this allele has been reported to predict risk of myocardial infarction. Whether this polymorphism increases risk of arterial and venous thrombosis among middle-aged men is unknown. Methods and Results Among 14 916 men 40 to 84 years old participating in the Physicians' Health Study who provided baseline blood samples for DNA analysis, 374 suffered first myocardial infarction and 121 had venous thromboembolism during 8.6 years of follow-up. Distributions of the 4G/5G polymorphism in the PAI-1 gene promoter were assessed in these men as well as in a sample of study participants matched on age and smoking who did not develop vascular occlusion during the prospective follow-up period. The distributions of the 4G/4G, 4G/5G, and 5G/5G genotypes among men who developed myocardial infarction (0.27, 0.51, 0.22; P =.7) or venous thromboembolism (0.30, 0.49, 0.21; P =.5) were virtually identical to those of men who remained free of vascular disease (0.27, 0.50, 0.23). Thus, the relative risk of future thrombosis among those with the 4G/4G genotype compared with those without the 4G/4G genotype was 1.02 (95% CI, 0.8 to 1.3). There was no effect modification by age, smoking status, family history of premature thrombosis, history of hypertension, hypercholesterolemia, or aspirin use. Conclusions These data indicate that the 4G/5G polymorphism in the promoter of the PAI-1 gene is not a major pathogenetic risk factor for arterial or venous thrombosis among middle-aged men.