Cytokines in Polymyalgia and Giant Cell Arteritis
Authors: John A. Getsy
Journal: Annals of Internal Medicine (1994)

Editorials1 October 1994Cytokines in Polymyalgia and Giant Cell ArteritisJohn A. Getsy, DMD, DO and S. Michael Phillips, MDJohn A. Getsy, DMD, DOUniversity of Pennsylvania School of Medicine; Philadelphia, PA 19104Search for more papers by this author and S. Michael Phillips, MDUniversity of Pennsylvania School of Medicine; Philadelphia, PA 19104Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-7-199410010-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Although it has been postulated that giant cell arteritis and polymyalgia rheumatica are a continuum of the same HLA-DR-associated disease process, the exact relation between the two conditions is still unknown. Giant cell arteritis is a well-characterized clinical entity. Histopathologic studies show a granulomatous, inflammatory reaction with a dense mononuclear leukocytic infiltration in the intima and media of large- and medium-sized arteries, along with giant cell infiltration of the internal elastic lamina [1]. Polymyalgia rheumatica is diagnosed primarily by clinical presentation of characteristic muscle pain and stiffness in the proximal portions of the extremities and torso, by increased erythrocyte sedimentation ...References1. Hunder GG. Giant cell (temporal) arteritis. Rheum Dis Clin North Am. 1990; 16(2):399-409. Google Scholar2. Hunder GG. Giant cell arteritis and polymyalgia rheumatica. In: Kelley WN and colleagues. Textbook of Rheumatology. Philadelphia: W.B. Saunders; 1989:1200. Google Scholar3. Weyand CM, Hicok KC, Hunder GG, Goronzy JJ. Tissue cytokine patterns in patients with polymyalgia rheumatica and giant cell arteritis. Ann Intern Med. 1994; 121:484-91. Google Scholar4. Banka PM, Cohen MD, Ginsburg WW, Hunder GG. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTissue Cytokine Patterns in Patients with Polymyalgia Rheumatica and Giant Cell Arteritis Cornelia M. Weyand , Kevin C. Hicok , Gene G. Hunder , and Jorg J. Goronzy Metrics Cited ByType 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases 1 October 1994Volume 121, Issue 7Page: 536-537KeywordsCellsCytokinesGiant cellsInflammationLesionsMacrophagesPathogensPolymyalgia rheumaticaT cell receptorsT cells Issue Published: 1 October 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...