Vitamin D Metabolite Levels in Oncogenic Osteomalacia
Authors: R. A. Sweet, James L. Males, Alan J. Hamstra, Hector F. DeLUCA
Journal: Annals of Internal Medicine (1980)

Brief Reports1 August 1980Vitamin D Metabolite Levels in Oncogenic OsteomalaciaR. A. SWEET, M.D., JAMES L. MALES, M.D., ALAN J. HAMSTRA, HECTOR F. DeLUCA, Ph.D.R. A. SWEET, M.D.Search for more papers by this author, JAMES L. MALES, M.D.Search for more papers by this author, ALAN J. HAMSTRASearch for more papers by this author, HECTOR F. DeLUCA, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-2-279 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypophosphatemic osteomalacia has been described in conjunction with a variety of mesenchymal tumors (1-3). This condition has also been called "oncogenic osteomalacia" and is associated with muscular weakness, hypophosphatemia, and bone roentgenograms compatible with osteomalacia or rickets. Resection of a localized tumor resolves the hypophosphatemia and osteomalacia. Drezner and Feinglos (4) noted that the hypophosphatemia and osteomalacia were associated with decreased levels of 1,25 dihydroxycholecalciferol (1,25(OH)2D3) which returned to normal after resection of a giant cell tumor of bone. These authors concluded that the low levels of 1,25(OH)2D3 were secondary to a tumor-produced factor that interfered with renal 25-hydroxycholecalciferol-1-hydroxylase activity....References1. SALASSA R, JOWSEY J, and ARNAUD C. Hypophosphatemic osteomalacia associated with "nonendocrine" tumors. N Engl J Med. 1970-283:65-70. CrossrefMedlineGoogle Scholar2. OLEFSKY J, KEMPSON R, JONES H, and REAVEN G. "Tertiary" hyperparathyroidism and apparent "cure" of vitamin-D-resistant rickets after removal of an ossifying mesenchymal tumor of the pharynx. N Engl J Med. 1972;286:740-5. CrossrefMedlineGoogle Scholar3. WYMAN A, PARADINAS F, and DALY J. Hypophosphataemic osteomalacia associated with a malignant tumor of the tibia: report of a case. J Clin Pathol. 1977;30:328-35. CrossrefMedlineGoogle Scholar4. DREZNER M and FEINGLOS M. Osteomalacia due to lα,25-dihydroxy-cholecalciferol deficiency: association with a giant cell tumor of bone. J Clin Invest. 1977;60:1046-53. CrossrefMedlineGoogle Scholar5. BIJVOET O. Kidney function in calcium and phosphate metabolism. In: AVIOLI LV, KRANE SM, editors. Metabolic Bone Disease. Vol. I. New York: Academic Press; 1977:50-140. CrossrefGoogle Scholar6. SHEPARD R, HORST R, HAMSTRA A, and DE LUCA H. Determination of vitamin D and its metabolites in plasma from normal and anephric man. Biochem J 1979;182:55-69. CrossrefMedlineGoogle Scholar7. BORDIER P, RASMUSSEN H, MIRAVET L, GUERIS J, and RYCKWAERT A. Vitamin D metabolites and bone mineralization in man. J Clin Endocrinol Metab. 1978;46:284-94. CrossrefMedlineGoogle Scholar8. ORNOY A, GOODWIN D, NOFF D, and EDELSTEIN S. 24,25 dihydroxyvitamin D is a metabolite of vitamin D essential for bone formation. Nature. 1978;276:517-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: R. A. SWEET, M.D.; JAMES L. MALES, M.D.; ALAN J. HAMSTRA; HECTOR F. 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