tbuckley/cabot-search huggingface dataset:
Prospective Study of Depression and the Risk of Heavy Alcohol Use in Women
Authors: Anita R. Dixit, Rosa M. Crum
Journal: American Journal of Psychiatry (2000)

OBJECTIVE: The authors' goal was to determine whether depression is associated with a greater risk of heavy alcohol consumption in women. METHOD: The study was based on a 1-year follow-up of the Baltimore cohort of the National Institute of Mental Health Epidemiologic Catchment Area project. The sample consisted of 1,383 women at risk for heavy alcohol use. History of depression and frequency of lifetime-experienced depressive symptoms were assessed at baseline, and incident cases of heavy drinking were identified 1 year later. After calculating descriptive statistics for the sample, the authors developed a series of logistic regression models to estimate the risk of heavy drinking at follow-up associated with depression status. RESULTS: The initial estimate of the risk for heavy drinking in women with a history of depressive disorder was 2.60 times greater than the risk in women with no history of depressive disorder. This estimate did not change markedly after adjustment for age, history of antisocial personality disorder, or father's history of heavy drinking (relative risk=2.2). A higher frequency of depressive symptoms was also found to be associated with an elevation in the risk for heavy alcohol use (relative risk=1.09). CONCLUSIONS: These results add to other evidence that depression must be considered in the assessment of vulnerability for heavy alcohol use in women. Further research is needed to clarify the mechanisms of the observed association and to discover whether detection and effective treatment of depression might reduce risk of later alcohol problems.
A Rearranged Form of Epstein–Barr Virus DNA Is Associated with Idiopathic Pulmonary Fibrosis
Authors: Brian G. Kelly, She S. Lok, Philip S. Hasleton, Jim J. Egan, James P. Stewart
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

An association between idiopathic pulmonary fibrosis (IPF) and productive Epstein-Barr virus (EBV) infection has been found previously. Productive EBV replication can be associated with a rearrangement in EBV genomes termed WZhet. We hypothesized that WZhet genomes might be present in patients with IPF. Thirty-nine patients with IPF, 26 lung transplant recipients, and 24 normal subjects were studied. When EBV DNA-positive lung tissue biopsies from IPF patients were analyzed, 11 of 18 (61%) were positive for WZhet. Buffy coat DNA analysis showed that 75-85% were EBV DNA-positive in both IPF and control groups. Buffy coat analysis for WZhet was positive in 16 of 27 (59%) IPF patients, compared with none of 32 lung transplant recipients and 1 of 24 (4%) normal blood donors (p < or = 0.001). There was thus a good correlation between the presence of WZhet in lung tissue and peripheral blood. However, there was no significant association between the presence of WZhet and immunosuppressive therapy. These data further confirm the association between active EBV infection and IPF and provide a potential marker in the peripheral blood for the tracking of EBV in this disease.
Levels of Soluble Cell Adhesion Molecules in Patients With Dyslipidemia
Authors: Anne Hackman, Yasunori Abe, William Insull, Henry Pownall, Louis Smith, Kay Dunn, Antonio M. Gotto, Christie M. Ballantyne
Journal: Circulation (1996)

Background Increased expression of cell adhesion molecules (CAMs) on the vascular endothelium has been postulated to play an important role in atherogenesis. Both in vitro and in vivo studies have suggested that dyslipidemia may increase expression of CAMs. Methods and Results To determine whether dyslipidemia is associated with increased expression of CAMs, we examined the levels of soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), and soluble E-selectin (sE-selectin) in individuals with either hypercholesterolemia or hypertriglyceridemia and in control subjects matched for age and sex. Patients with hypertriglyceridemia had significantly higher levels of sVCAM-1 (739±69 ng/mL) compared with patients with hypercholesterolemia (552±63 ng/mL) and control subjects (480±56 ng/mL). Levels of sICAM-1 were significantly increased in both the hypercholesterolemic and hypertriglyceridemic groups (298±29 and 342±31 ng/mL, respectively) compared with the control group (198±14 ng/mL). Levels of sE-selectin were significantly increased in hypercholesterolemic patients (74±9 ng/mL) compared with control subjects (48±5 ng/mL). Ten hypercholesterolemic patients were treated aggressively with atorvastatin alone or a combination of colestipol and either atorvastatin or simvastatin for a mean of 42 weeks and had an average LDL cholesterol reduction of 51%. Comparison of soluble CAMs before and after treatment showed a significant reduction only in sE-selectin (77±11 versus 56±6 ng/mL, P ≤.03) but not for sVCAM-1 or sICAM-1. Conclusions Although severe hyperlipidemia is associated with increased levels of soluble CAMs, aggressive lipid-lowering treatment had only limited effects on the levels. Increased levels of soluble CAMs in patients with hyperlipidemia may be a marker for atherosclerosis.
Small malignant melanomas: Clinicopathologic correlation and DNA ploidy analysis
Authors: Hideko Kamino, Hiromaro Kiryu, Howard Ratech
Journal: Journal of the American Academy of Dermatology (1990)

Among the various clinical and histologic criteria used to differentiate between benign and malignant melanocytic neoplasms, emphasis has been placed on the size of the lesion. Malignant melanomas, when diagnosed, are usually larger than 6 mm in diameter whereas most acquired melanocytic nevi tend to be smaller. We tested this size criterion with a retrospective clinicopathologic study of 30 proliferations of atypical melanocytes within the epidermis and dermis that measured less than 6 mm in diameter. Nineteen cases fulfilled all 15 established histologic criteria for the diagnosis of malignant melanoma. The remaining 11 cases fulfilled 14 of 15 criteria. Four of eight of these small malignant melanomas analyzed by multiparameter flow cytometry were aneuploid (DNA ploidy index ≤0.9 or ≥1.1). The sex ratio, race, and anatomic sites associated with these small melanomas were similar to those described in patients with malignant melanomas larger than 6 mm in diameter. Furthermore, one melanoma metastasized to a regional lymph node and another recurred. We conclude that small malignant melanomas less than 6 mm in diameter can have histologic features, DNA abnormalities, clinical presentations, and biologic potentials similar to larger lesions.
Quantitation of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic hematopoietic stem cell transplantation
Authors: Takahiro Shima, Toshihiro Miyamoto, Yoshikane Kikushige, Yasuo Mori, Kenjiro Kamezaki, Ken Takase, Hideho Henzan, Akihiko Numata, Yoshikiyo Ito, Katsuto Takenaka, Hiromi Iwasaki, Tomohiko Kamimura, Tetsuya Eto, Koji Nagafuji, Takanori Teshima, Koji Kato, Koichi Akashi
Journal: Blood (2012)
VOICE IN FEMALE SINGERS AFFECTED BY GYNECOLOGICAL DISORDERS
Authors: CARL H. VON KLEIN
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letting HIV Transform Academia — Embracing Implementation Science
Authors: Wafaa M. El-Sadr, Neena M. Philip, Jessica Justman
Journal: New England Journal of Medicine (2014)

The human immunodeficiency virus (HIV) epidemic has had an extraordinary global impact. Even as it has devastated societies, it has also inspired community empowerment, motivated impressive scientific discoveries, and provoked an unprecedented mobilization of vast resources for a single health condition. Not yet fully realized, however, is the epidemic's potential for expanding the core mission of academic institutions to include the pursuit of a wider range of research.Most universities focus on three core missions: transmitting knowledge to undergraduate students, developing the next generation of scholars through graduate education, and producing new discoveries through research. In both education and research, . . .
Cellular immune responses in patients with dual infection of hepatitis B and C viruses: Dominant role of hepatitis C virus
Authors: Sun-Lung Tsai, Yun-Fan Liaw, Chau-Ting Yeh, Chia-Ming Chu, George C. Kuo
Journal: Hepatology (1995)

Several lines of evidence have suggested that immune mechanisms are involved in the pathogenesis of hepatitis B virus (HBV)- and hepatitis C virus (HCV)-related hepatitis. Study of patients with dual HBV and HCV infection raises the question of which is etiologically more relevant in determining the liver cell damage. To address this issue, proliferation of peripheral blood mononuclear cells (PBMCs) in response to a panel of HBV and HCV antigens was assayed in 13 patients with chronic dual hepatitis B and C, 7 patients with chronic hepatitis B, 7 patients with chronic hepatitis C, and 6 patients with hepatitis B surface antigen (HBsAg) carrier state. Although HBV or HCV hepatitis patients had a significant response to HBV or HCV antigens, respectively, the patients with dual hepatitis B and C exclusively responded to HCV antigens, but not to HBV antigens. One patients who was seropositive for both HBV-DNA and HCV-RNA showed a low response to HBV antigens initially but lost the response 3 months later and became responsive to more HCV antigens. These findings suggest that HCV has a dominant role in the immune response of the patients with dual HBV and HCV infection.
Polymyositis and Dermatomyositis
Authors: James F. Toole
Journal: JAMA (1989)

Dalakas and his 15 contributors have constructed a workable and informative consideration of the myositides. Because of their number and many disciplines, it is not surprising that there are some areas of overlap and disagreement among the authors. Most striking is the contrast between the classification provided by Dalakas and those of Bohan, Fenichel, Rosenburg, Carry, and Ringel. That of Dalakas is an amalgam of classifications by age and response to therapy, whereas those of the latter authors are more etiologically directed. Chapters by seasoned researchers and clinicians are divided into clinical features, etiology and mechanisms, and diagnosis and treatment, as well as a concluding overview of the subject. Throughout, the book has many nuggets of information that make it well worth reading, such as the statement (p 33) that approximately 12% of patients have normal muscle biopsy results even during active myositis. To quote further, "This should not discourage
The Maloja Sanatorium and Spa
Authors: A. Tucker
Journal: BMJ (1884)

the Dermatological Department of the Museum of the Royal College of Surgeons of England may be seen a specimen bearing the designation " neuropathic plica."It was presented by me to the Museum through, and at the kind suggestion of, Sir Erasmus Wilson; and I believe I am correct in saying that it is the only one in existence, at least, so far as I have been able to ascertain.At a time when the list of diseases of the nervous system is greatly in- creasing-pathological research having traced to that system as the fountain many not only so-called functional, but even organic dis- eases-to add a new name to the list appears to require some apo&Igy.The apology I offer is that, inasmuch as it would be highly incon4enient to designate a newly recognised disease by an old name, no choice is left but the adoption of a term not contained in our nomenclature.That the disease is neuropathic, I shall en- deavour to make clear.That it is new, I shall not attempt to prove.Probably, the novelty is wholly comprised in the recognition of a condition of things which, considering the prevalence of the disease with which it was associated, has many times occurred, but which has hitherto illuded the vigilance of observers.The only plica of our nomenclature is plica polonica.In this the scalp is inflamed and excessively tender, and the hair-follicies secrete in abundance a reddish viscous fluid, " which agglutinates the hairs, and by desiccation unites them into a solid mass."The >whole length of the hairs is surcharged with the fluid; and, if, a -siagle hair be cut, it may be seen oozing from the divided portion.In neuropathic plica the scalp is structurally healthy, and neither ,the&ollicle nor the hair itself presents any structural evidence of disease.The plication is not the result 'of agglutination, but is wholly effected by structural changes produced by a force within.'The arrangement of the hair is not characterised by disorder and con- fusion, but by a certain symmetry which is remarkable and' most extraordinary.The case is briefly recorded in the following notes.J. H., aged 17, consulted me on September 30th, 1882.She stated that for six or seven days she had felt ill, complaining of more or less general numbness; and that, on' September 29th, she suffered the wlhole day from severe headache, which affected chiefly the brow, together with the sensation of "' pins and needles" over the scalp.In tihe hope of obtaining relief, she, in the evening, washed her hiead in warm, but not hot, water.After partially drying her hair, which measured three feet one inch in length, with a towel, she commenced combing it out on the left side, in the presence of her parents, who are intelligent and reliable people, and, whilst so ,engaged, she felt a tearing sensation on the right side of her head, as though the hair were being pulled out, and, on placing her hand
Children and adults with primary antibody deficiencies gain quality of life by subcutaneous IgG self-infusions at home
Authors: Ann Gardulf, Uwe Nicolay, Oscar Asensio, Ewa Bernatowska, Andreas Böck, Beatriz T. Costa-Carvalho, Carl Granert, Stefan Haag, Dolores Hernández, Peter Kiessling
Journal: Journal of Allergy and Clinical Immunology (2004)
Comparison of Standard Kiil and Pyramid-Surface Dialyzers
Authors: Henry Yager
Journal: JAMA (1972)

In a recently developed hemodialyzer, closely set rows of tiny, flat-topped pyramids have been substituted for the usual parallel grooves on the membrane-supporting surfaces of standard Kiil artificial kidneys. We compared dialysance rates for urea, creatinine, and phosphate in the old and new kinds of kidney. For all three substances, rate of dialysance was approximately 50% greater in the pyramid-surface machines than in the Kiil kidneys. These data suggest that the substitution of the pyramids for the usual parallel grooves on kidney boards will permit reduction of dialysis time by one third.
Impotence in Systemic Sclerosis
Authors: SHAUL SUKENIK
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 June 1987Impotence in Systemic SclerosisSHAUL SUKENIK, M.D., JACOB HOROWITZ, M.D., DAN BUSKILA, M.D., JACOB M. ABARBANEL, M.D., LEONARD LISMER, M.D., ILANA AVINOACH, M.D.SHAUL SUKENIK, M.D.Search for more papers by this author, JACOB HOROWITZ, M.D.Search for more papers by this author, DAN BUSKILA, M.D.Search for more papers by this author, JACOB M. ABARBANEL, M.D.Search for more papers by this author, LEONARD LISMER, M.D.Search for more papers by this author, ILANA AVINOACH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-6-910_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nowlin and associates (1) reported the cases of six patients with scleroderma who were impotent. The pathogenesis of impotence in scleroderma is not known, and the authors raise the possibility that involvement of penile small arteries may be of importance.We recently reported (2) a unique case of progressive systemic sclerosis in a 45-year-old man with impotence, bilateral carpal tunnel syndrome, and peripheral neuropathy as presenting symptoms. Biopsy sample of the sural nerve did not show any evidence of vasculitis or infiltration of the nerve, but electron microscopy showed electron-opaque bodies and collagen pockets in many unmyelinated...References1. NOWLINBRICKWEAVER NJD. Impotence in scleroderma. Ann Intern Med. 1986;104:794-8. LinkGoogle Scholar2. SUKENIKABARBANELBUSKILAPOTASHNIKHOROWITZ SJDGJ. Impotence, carpal tunnel syndrome and peripheral neuropathy as presenting symptoms in progressive systemic sclerosis. J Rheumatol. 1987. (In press). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ben Gurion University Beer Sheva Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySexualidade e doenças reumáticasThe clinical relevance of sexual dysfunction in systemic sclerosisThe ‘Connective Tissue Diseases’The impact of rheumatic diseases on sexual functionPenile curvature associated with sclerodermaSystemic Sclerosis and Impotence: A Clinicopathological CorrelationErektile Dysfunktion bei speziellen KrankheitsbildernNeurological complications of systemic sclerosis-a report of three cases and review of the literatureProgressive systemic sclerosis (scleroderma) and impotence 1 June 1987Volume 106, Issue 6Page: 910-911KeywordsArteriesBiopsyElectron microscopyErectile dysfunctionNervesPathogenesisPeripheral neuropathySclerodermaVasculitis Issue Published: 1 June 1987 PDF DownloadLoading ...
Comparative ultrastructural morphology of human basophils stimulated to release histamine by anti-IgE, recombinant IgE-dependent histamine-releasing factor, or monocyte chemotactic protein-1
Authors: Ann M. Dvorak, John T. Schroeder, Donald W. MacGlashan, Karen P. Bryan, Ellen S. Morgan, Lawrence M. Lichtenstein, Susan M. MacDonald
Journal: Journal of Allergy and Clinical Immunology (1996)

An ultrastructural analysis of human basophils stimulated with anti-IgE, recombinant histamine-releasing factor (rHRF), or monocyte chemotactic protein-1 (MCP-1) (compared with unstimulated cells) was performed. Partially purified peripheral blood basophils were prepared for electron microscopy at time points known to precede histamine release and at half-maximum histamine release times for each secretagogue. Activation morphologies associated with stimulation included granule-vesicle attachments, piecemeal degranulation, anaphylactic degranulation, and uropod formation. These features were qualitatively similar in the stimulated samples. Quantitative differences were evident, however, when stimulated samples were compared with controls or at different time points after stimulation with a single agent or when individual secretagogues were compared. All stimulated samples differed quantitatively from the control samples. Rank orders for morphologic activation events revealed that the most effective trigger for anaphylactic degranulation was anti-IgE > MCP-1 > rHRF, whereas the most effective trigger for uropod formation was rHRF > anti-IgE > MCP-1. Rank orders for piecemeal degranulation and granule-vesicle attachments were the same: MCP-1 > anti-IgE > rHRF. Important relationships among these anatomic events reveal that the development of motile configurations is not associated with the development of secretion morphologies and that piecemeal degranulation precedes and is inversely related to anaphylactic degranulation in stimulated samples.
Trusts are failing to check on locums
Authors: D. Carnall
Journal: BMJ (1999)

On any one day 3500 locums are at work in NHS trusts at an annual cost of £214m ($342m), according to the latest Audit Commission report. The commission suggests that this bill could be reduced by as much as 10%mainly by minimising the fees paid to agencies, but its main concern is the quality of care provided by locums. …
Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84
Authors: Jennifer L. Cannons, Hai Qi, Kristina T. Lu, Mala Dutta, Julio Gomez-Rodriguez, Jun Cheng, Edward K. Wakeland, Ronald N. Germain, Pamela L. Schwartzberg
Journal: Immunity (2010)
Acute renal failure associated with carbenoxolone treatment.
Authors: B Hurley
Journal: BMJ (1977)

Management of childhood epilepsy SIR,-I hope that Dr H Wykeham Balme (14 May, p 1284) does not imply that all children with epilepsy should live in a home with prdtected staircases, without bathroom locks, and with guards around the fires and radiators; that they should bath in less than three inches of water, go to school accompanied, and not climb trees or go swimming or camping.
Responses of coronary vessels to adrenergic stimuli
Authors: Donald R. McRaven, Allyn L. Mark, Francois M. Abboud, Howard E. Mayer
Journal: Journal of Clinical Investigation (1971)

Coronary responses to adrenergic stimuli were determined in the intact beating heart before and after administration of practolol, 4-(2-hydroxy-3-isopropylaminoproproxy) acetanilide, which in low doses blocks myocardial but not vascular beta receptors. The left circumflex coronary artery of dogs was perfused with arterial blood at constant flow, and coronary perfusion pressure was measured. Before practolol, intracoronary injections of isoproterenol and norepinephrine and electrical stimulation of left cardiac sympathetic nerves caused reductions in perfusion pressure or vasodilatation associated with increases in left ventricular dp/dt, heart rate, and systolic pressure. After practolol, the coronary vasodilator response to isoproterenol was reduced by about 30% and occurred without significant changes in dp/dt, heart rate, and pressures. The addition of propranolol blocked completely the coronary responses to isoproterenol. Vascular responses to isoproterenol in the paw were not altered by practolol. Practolol antagonized the increases in dp/dt, heart rate, and systolic pressure and reversed coronary responses to norepinephrine and nerve stimulation from dilatation to constriction. The constriction, in turn, was reduced or reversed by phentolamine, an alpha receptor antagonist. Propranolol did not augment the constriction seen in response to norepinephrine and nerve stimulation after practolol. These results indicate that the coronary vasodilator action of norepinephrine and sympathetic nerve stimulation is indirect and caused by stimulation of myocardial beta receptors. The direct effect of these two stimuli on coronary vessels is minimal and is mediated through stimulation of alpha (vasoconstrictor) receptors. In contrast, the coronary vasodilator response to isoproterenol is both direct and indirect, resulting from stimulation of vascular and myocardial beta receptors; the direct vascular effect predominated in this study.