Bone Marrow Gas Tensions, Bone Marrow Blood Flow, and Erythropoiesis in Man
Authors: JOSEPH L. GRANT
Journal: Annals of Internal Medicine (1963)

Article1 May 1963Bone Marrow Gas Tensions, Bone Marrow Blood Flow, and Erythropoiesis in ManJOSEPH L. GRANT, M.D., F.A.C.P., BARRY SMITH, M.D.JOSEPH L. GRANT, M.D., F.A.C.P., BARRY SMITH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-5-801 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor many years bone marrow anoxia was thought to stimulate erythropoiesis, but there is growing acceptance of the belief that a hormone, erythropoietin, provides the marrow with the immediate stimulus for blood production. In 1948, Berk, Burchenal, Wood, and Castle (1), and, in 1949, Schwartz and Stats (2) found that oxygenation of bone marrow was increased in states of marrow overactivity. Reissmann (1950) found increased hemopoiesis in the normal partner when 1 of a pair of parabiotic rats breathed a low oxygen gas mixture (3). Stohlman, Rath, and Rose (1954) found that in reverse patent ductus arteriosus the well-oxygenated sternal...References1. BERKBURCHENALWOODCASTLE LJHTWB: Oxygen saturation of sternal marrow blood with special reference to pathogenesis of polycythemia vera. Proc. Soc. Exp. Biol. Med. 69: 316, 1948. CrossrefMedlineGoogle Scholar2. SCHWARTZSTATS BMD: Oxygen saturation of sternal marrow blood in polycythemia vera. J. Clin. Invest. 28: 736, 1949. CrossrefMedlineGoogle Scholar3. REISSMANN KR: Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. Blood 5: 372, 1950. CrossrefMedlineGoogle Scholar4. STOHLMANRATHROSE FCEJC: Evidence for a humoral regulation of erythropoiesis. Blood 9: 721, 1954. CrossrefMedlineGoogle Scholar5. JACOBSONMARKSGASTONGOLDWASSER LOEKEOE: Studies on erythropoiesis. XI. Reticulocyte response of transfusion-induced polycythemic mice to anemic plasma from nephrectomized rats exposed to low oxygen. Blood 14: 635, 1959. CrossrefMedlineGoogle Scholar6. GALLAGHERMCCARTHYLANGE NIJMRD: Observations on erythropoietic stimulating factor (ESF) in the plasma of uremic and nonuremic anemic patients. Ann. Intern. Med. 52: 1201, 1960. LinkGoogle Scholar7. KURATOWSKALEWARTOWSKIMICHALAK ZBE: Studies on the production of erythropoietin by isolated perfused organs. Blood 18: 527, 1961. CrossrefMedlineGoogle Scholar8. ROSSEWALDMANN WFTA: The role of the kidney in the erythropoietic response to hypoxia in parabiotic rats. Blood 19: 75, 1962. CrossrefMedlineGoogle Scholar9. WINTROBE MM: Clinical Hematology, 5th ed., Lea & Febiger, Philadelphia, 1961, pp. 50-51. Google Scholar10. RILEYPROEMMELFRANKE RLDDRE: Direct method for determination of O2 and CO2 tensions in blood. J. Biol. Chem. 1961: 621, 1945. CrossrefGoogle Scholar11. DILL JB: Handbook of Respiratory Data in Aviation, Office of Scientific Research and Development, Washington, D. C., 1944. Google Scholar12. CROSBYMUNNFURTH WHJIFW: Standardizing a method for clinical hemoglobinometry. US Armed Forces Med. J. 5: 693, 1954. MedlineGoogle Scholar13. MacLeod's Physiology in Modern Medicine, 9th ed., C. V. Mosby Company, St. Louis, 1941, p. 633. Google Scholar14. SCHOBINGER RA: Intra-Osseous Venography, Grune & Stratton, Inc., New York, 1960, Chap. 4. Google Scholar15. RODMANCLOSEPURCELL THPMK: The oxyhemoglobin dissociation curve in anemia. Ann. Intern. Med. 52: 295, 1960. LinkGoogle Scholar16. HUFFHENNESSYAUSTINGARCIAROBERTSLAWRENCE RLTGREJFBMJH: Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders. J. Clin. Invest. 29: 1041, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: White River Junction, VermontFrom the Medical and Research Services, Veterans Administration Hospital, White River Junction, Vermont, and the Dartmouth Medical School, Hanover, New Hampshire.Requests for reprints should be addressed to Joseph L. Grant, M.D., Veterans Administration Center,White River Junction, Vermont. 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