Antimalarial Drugs in West Africa
Authors: L. J. Bruce-Chwatt, J. M. Bruce-Chwatt
Journal: BMJ (1950)

INOCULATIONBRmmfsn 7 inoculation from each of the five children whose stools have so far been tested.The rhesus monkeys used all developed a disease similar to experimental poliomyelitis, and lesions pathognomonic of the disease were found in the brain and cord at necropsy.Case J.-R. R., aged 10 years.June, 1949.Revaccinated with smallpox lymph with "mild take" 12 days previous to the onset of symptoms.Developed meningo-encephalitis with evidence of paresis of the seventh cranial nerve four days after onset.Stool collected on the sixth day of illness.Case 2.-S.S., aged 91 months.September, 1949.Combined diphtheria-pertussis vaccine injected 17 days previous to onset.Paralysis of both arms three days after onset.Stool collected on the fourth day of illness.Case 3.-D.M., aged 1 year.October, 1949.A.P.T. vaccine injected nine days previous to onset of symptoms.Paralysis, localized to inoculated arm, 12 days after injection.Stool collected on the 14th day of illness.Case 4.-J.R., aged 1 year.December, 1949.Pertussis vaccine injected four days previous to onset of "cold."Paralysis, confined to inoculated limb, seven days after onset of ". cold."Stool collected on the tenth day of illness.Case 5.-R.W., aged 1 year 71 months.December, 1949.Pertussis vaccine injected five days previous to onset of symp- toms.Could not swallow two days after onset, and paralysis of neck muscles occurred on the following day.Stool collected on the 20th day of illness.Cases 3 and 4 appear to be examples of the "double event" under discussion.In Cases 1, 2, and 5 the association between inoculation and poliomyelitis-like illness was present, but paralysis was not confined to the inoculated limb.Summary Poliomyelitis virus has been isolated from the stools of two children who had paralysis of a limb inoculated 11 and 12 days previously with certain vaccines.The virus has also been isolated from the stools of three children -who developed poliomyelitis or encephalitis 5 to 17 days after receiving a prophylactic inoculation without localization of paralysis in the inoculated limb.It is recognized that the poliomyelitis virus is widespread during gpidemic times, and no suggestion is made here that the viruses isolated were necessarily responsible for the present illness of the patients.These strains will be used, however, for experimental investigation of the problem of the effect of peripheral trauma in precipitating poliomyelitis or localiza- tion of paralysis in patients infected with or carrying poliomyelitis viruses.The National Insurance Advisory Committee has been asked to consider and report on the preliminary draft of regulations which would modify the time limits for giving notice of incapacity and' claiming sickness benefit for persons in hospi- tal and for those who have not claimed that benefit before under the National Insurance Act.The proposals in the draft regulations are that a person claiming sickness benefit for the first time would have 21 days to put in his claim and would not be disqualified for having failed to give notice of incapacity.Long-stay patients in hospital would be treated as having good cause for failure to claim sickness benefit within the normal time limits while they are in hospital up to a maximum of three months; for short-stay patients this period would instead be the time spent in hospital and the three weeks after discharge.