tbuckley/cabot-search huggingface dataset:
Medical management of chronic gastric ulcer
Authors: D. Ferriman
Journal: Gut (1962)

The results of medical treatment in 113 patients with chronic ulceration of the angulus and vertical part of the stomach are reported. The ulcers failed to heal in 38% and healed but recurred in 22%. The ulcers healed and, except for minor recurrences in a few, remained healed for five years in 40%. The prognosis for patients with ulcers with long histories and large ulcers was poor, and this is true of other series reported in the literature. If such cases had been excluded from the present series the success rate would have risen to 64%. Patients with ulcers in these two categories should be referred for surgery. It is suggested that a trial of medical treatment is justifiable in most other cases, surgery being reserved for its failures.
Calcification of the Peritoneum
Authors: A. J. Webster, T. Semple
Journal: BMJ (1951)

CHLORAMPHENICOL IN STAPHYLOCOCCAL MENINGITISBrDIcrms 1069 the patient was symptomless and was, in fact, making persistent demands for permission to' get up.Intrathecal chloramphenicol was discontinued after six days, and oral therapy after 12 days.The results of three assays per- formed on the lumbar fluid are shown in the Table .The patient maintained uninterrupted progress and was allowed to get up.
Melatonin Improves Sleep in Asthma
Authors: Francineide L. Campos, Francisco P. da Silva-Júnior, Veralice M. S. de Bruin, Pedro F. C. de Bruin
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Disturbed sleep is common in asthma. Melatonin has sleep-inducing activity and reportedly affects smooth muscle tone and inflammation. The aim of this study was to evaluate the effect of melatonin on sleep in patients with mild and moderate asthma. This was a randomized, double-blind, placebo-controlled study. Twenty-two consecutive women with asthma were randomized to receive melatonin 3 mg (n = 12) or placebo (n = 10) for 4 weeks. Sleep quality and daytime somnolence were assessed by the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale, respectively. Pulmonary function was assessed by spirometry. Use of relief medication, asthma symptoms, and morning and evening peak expiratory flow rate were recorded daily. Melatonin treatment significantly improved subjective sleep quality, as compared with placebo (p = 0.04). No significant difference in asthma symptoms, use of relief medication and daily peak expiratory flow rate was found between groups. We conclude that melatonin can improve sleep in patients with asthma. Further studies looking into long-term effects of melatonin on airway inflammation and bronchial hyperresponsiveness are needed before melatonin can be recommended in patients with asthma.
Characterization of the autoantibody responses to recombinant E3 binding protein (protein X) of pyruvate dehydrogenase in primary biliary cirrhosis
Authors: Jeremy M. Palmer, David E. Jones, Janet Quinn, Anna McHugh, Stephen J. Yeaman
Journal: Hepatology (1999)

Autoantibodies to the pyruvate dehydrogenase complex (PDC) are present in the serum of more than 95% of patients with primary biliary cirrhosis (PBC), the major epitope being the inner lipoyl domain of the E2 component. Immunoblotting suggests a similar prevalence of antibodies to a tightly associated lipoic acid-containing protein, E3 binding protein (E3BP). Attempts to resolve E3BP from E2 have been unsuccessful, restricting study of the nature and significance of antibody responses to the individual proteins. In particular, it is unclear (1) whether there is true cross-reactivity between E3BP and E2 and, if so, which is the originating response and (2) whether autoantibodies preferentially bind a lipoylated epitope on E3BP as is the case with PDC-E2. In this study, complementary DNAs encoding rE2, full-length rE3BP, its single lipoyl domain (rLip), and core domain (rE3BPCore) were cloned, and the proteins were expressed in Escherichia coli. Sera from 47 PBC patients were studied by immunoblotting and enzyme-linked immunosorbent assay (ELISA) against rE2, rE3BP, rE3BPCore, and both unlipoylated (U) and lipoylated (L) rLip. All sera were reactive by ELISA to some degree with all recombinant proteins except rE3BPCore, to which only 6 of 47 showed any reactivity. Significant correlations (P <.0001) were observed when comparing absorbance values for rE3BP with both rLip (U) (r = 0.793) and (L) (r = 0.963). The mean absorbance for rLip (U, 0.26 +/- 0.05) was, however, significantly lower than the absorbance for rLip (L) (0.78 +/- 0.12; P <.0001). After probing by immunoblotting and elution of antibodies from rE2 and rE3BP, subsequent reprobing against the components in whole PDC revealed true cross-reactivity. In summary, the response to E3BP is primarily directed against the lipoylated domain of the protein. It still remains unclear, however, whether the initial breakdown of tolerance is to E2 or E3BP.
Carboxyhaemoglobin in women exposed to different cooking fuels.
Authors: D Behera, S Dash, S P Yadav
Journal: Thorax (1991)

Blood carboxyhaemoglobin levels were estimated by double wavelength spectrophotometry in non-smoking women living in Chandigarh and its environs and related to the cooking fuel they used. Twenty nine used kerosene, 28 biomass fuel, and 30 liquified petroleum gas; the 27 control subjects had not done any cooking for seven days. The carboxyhaemoglobin concentrations were significantly higher in the women using the three types of fuel (mean (SEM) concentration 7.49% [corrected] (0.67%) for kerosene, 15.74% (0.83%) for biomass fuel, and 17.16% (0.62%) for liquified petroleum gas, compared with 3.52% (0.33%) in the control subjects. It is concluded that cooking with any of the three fuels causes indoor air pollution. It is important to have better designed houses with adequate ventilation and stove vents that are cleaned regularly if pollution is to be reduced.
A lack of positive effect of enhanced vegetative nervous system tonus on mobilization of hematopoietic stem and progenitor cells in patients suffering from acute psychotic syndromes
Authors: J Kucharska-Mazur, D Pedziwiatr, A Poniewierska, M Tkacz, M Suszynska, M Tarnowski, J Samochowiec, M Z Ratajczak
Journal: Leukemia (2012)
Methotrexate for Juvenile Rheumatoid Arthritis
Authors: Patience H. White, Barbara M. Ansell
Journal: New England Journal of Medicine (1992)

Juvenile rheumatoid arthritis, an idiopathic inflammatory disorder, is the most common of the rheumatic diseases in children and is an important cause of disability. The diagnosis is made when a child less than 16 years of age has arthritis for at least six weeks with no other apparent cause. Juvenile rheumatoid arthritis is not a single disease but a heterogeneous group of diseases, many of which are different from adult rheumatoid arthritis. After six months of disease three major patterns can be identified. Disease of systemic onset accounts for 10 to 20 percent of cases and is defined as arthritis . . .
Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. A possible mechanism of neovascularization in atherosclerotic plaques.
Authors: K Fukuo, T Inoue, S Morimoto, T Nakahashi, O Yasuda, S Kitano, R Sasada, T Ogihara
Journal: Journal of Clinical Investigation (1995)

To define the pathophysiological role of nitric oxide (NO) released from vascular smooth muscle cells (VSMC), we examined whether NO released from VSMC induces cytotoxicity in VSMC themselves and adjacent endothelial cells (EC) using a coculture system. Prolonged incubation with interleukin-1 (IL-1) induced large amounts of NO release and cytotoxicity in VSMC. NG-Monomethyl-L-arginine, an inhibitor of NO synthesis, inhibited both NO release and cytotoxicity induced by IL-1. In contrast, DNA synthesis in cocultured EC was not inhibited but rather stimulated by prolonged incubation with IL-1 or sodium nitroprusside (SNP), a NO donor. However, IL-1 and SNP did not stimulate but inhibited DNA synthesis in EC alone. On the other hand, conditioned medium from VSMC incubated for a long period with IL-1 or SNP stimulated DNA synthesis in EC alone. Furthermore, the concentration of basic fibroblast growth factor in the conditioned medium was increased and correlated with the degree of cytotoxicity in VSMC. These results indicate that NO released from VSMC induces VSMC death, which results in release of basic fibroblast growth factor, which then stimulates adjacent EC proliferation. Thus, NO released from VSMC may participate in the mechanism of neovascularization in atherosclerotic plaques.
THE ENDOCRINE CAUSATION OF SCLERODERMA, INCLUDING MORPHŒA
Authors: W. F. CASTLE
Journal: British Journal of Dermatology (1923)

Journal Article THE ENDOCRINE CAUSATION OF SCLERODERMA, INCLUDING MORPHŒA Get access W. F. CASTLE, D.S.C., B.A., M.B., B.Ch.(Cantab.). W. F. CASTLE, D.S.C., B.A., M.B., B.Ch.(Cantab.). Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 35, Issue 7, 1 July 1923, Pages 255–278, https://doi.org/10.1111/j.1365-2133.1923.tb09116.x Published: 01 July 1923
Colorectal carcinoma in patients with ulcerative colitis and recent colonoscopy.
Authors: S M Catnach, K R Rutter, R L Bown
Journal: Gut (1993)

Longstanding ulcerative colitis, particularly pancolitis, is associated with an increased risk of colorectal neoplasia. For this reason surveillance colonoscopy at regular intervals has been recommended to identify early cancers or high grade dysplasia. Three cases are described of patients with ulcerative colitis of greater than 10 years duration who presented with colorectal carcinoma within three years of colonoscopy.
Serum Sialic Acid Concentration and Coronary Heart Disease in NIDDM
Authors: John C Pickup, Martin B Mattock, Martin A Crook, Gary D Chusney, Davina Burt, Anthony P Fitzgerald
Journal: Diabetes Care (1995)

OBJECTIVE To examine the association between serum sialic acid concentrations and coronary heart disease (CHD) in a cross-sectional study of non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS NIDDM patients (n = 145) attending a diabetic clinic were studied. CHD status was assessed by questionnaire and electrocardiogram coding, and potential risk factor assessment included measurement of fasting serum lipid and lipoprotein concentrations, blood pressure, and urinary albumin excretion rate (AER). RESULTS Male NIDDM patients with CHD had a higher serum sialic acid level than those without CHD: 2.56 (2.24, 2.72) mmol/l vs. 2.24 (2.18, 2.30) mmol/l, P = 0.01, mean (95% confidence interval). They were also older, had a longer duration of diabetes, had a higher AER, had higher total triglyceride, very-low-density lipoprotein triglyceride and cholesterol, and lipoprotein(a) concentrations, and had a lower apolipoprotein A1 concentration. In an age adjusted multiple lipoprotein(a), hypercholesterolemia, and hypertension were associated with CHD. In women, only hypertension treatment was associated with CHD. CONCLUSIONS There is a strong univariate association between elevated serum sialic acid and CHD in men (but not women) with NIDDM.
FDA Chief Scientist
Authors: Bridget M. Kuehn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cellular cardiomyoplasty with bone marrow cells improves cardiac performance in heart failure induced by healed infarct in rats
Authors: Emerson Olivares, V. Pinho-Ribeiro, J.P. Saar Werneck, R.C. Santos Goldenberg, Elizabeth Mattos, Hans F. Dohmann, Masako O. Masuda, Antonio C. Campos de Carvalho
Journal: Journal of the American College of Cardiology (2003)
αβ T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities
Authors: Anastasia N. Tikhonova, François Van Laethem, Ken-ichi Hanada, Jinghua Lu, Leonid A. Pobezinsky, Changwan Hong, Terry I. Guinter, Susanna K. Jeurling, Günter Bernhardt, Jung-Hyun Park, James C. Yang, Peter D. Sun, Alfred Singer
Journal: Immunity (2011)
Annual Physical Examination and Detection of Breast Cancer
Authors: Renate G. Justin
Journal: JAMA (1977)

To the Editor.—  In the article Detection of Breast Cancer in Young Women (237:967, 1977), Lesnick states that 84% of the women in his series detected their own lesions. This figure agrees with that stated by others. 1 The experience in a family practice (rather than a surgical practice) is different. During approximately the same years (1962 to 1977) as those studied by Lesnick, 29 women who had cancer of the breast were seen in family practice. Their ages ranged from 30 to 83 years. In this group, only ten (34%) of the patients found their own lesions; nineteen (66%) were detected by the physician on routine physical examination.  Thirteen of the 29 women had mammography or xeromammography. Four examinations were positive; nine were negative. This agrees with Lesnick's findings of 69% failure to demonstrate the cancer by roentgenogram. Twelve (41%) of the 29 patients had positive nodes at the
THE WAR NEUROSES
Authors: WILLIAM B. TERHUNE
Journal: JAMA (1918)

Few subjects have attracted more attention in medical circles since the beginning of the war than the war neuroses. Each belligerent nation has been confronted with the problem of caring for large numbers of soldiers afflicted with marked nervous manifestations resulting from the strain of war. The careful consideration of this form of nervous and mental instability was found to be of military as well as of medical importance. The military authorities wished to know how this condition might be prevented, what percentage of men would be cured and how soon, and to what degree an individual was responsible for his actions while he was so afflicted. The armed forces of the United States must now, by force of circumstances, consider the same problem, and while much has been written concerning this matter, I believe that a description of how the condition is actually cared for in the English army
1278 MITOCHONDRIAL UNCOUPLING PROTEIN 1 (UCP1) EXPRESSION IN WHITE ADIPOSE TISSUE DECREASES WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) PROGRESSION IN MORBID OBESITY
Authors: A. Carazo, L. Sanjuan, A. Gila, J.A. Munoz, L.M. Alcazar, A. Martin, J. Leon, J.A. Jimenez, J. Garcia, C. Fernandez, F. Aguilar, T. Caballero, J. Salmeron
Journal: Journal of Hepatology (2012)
A Textbook of Gynaecology and Obstetrics
Authors: S. B. Gusberg
Journal: JAMA (1964)

This is the most recent British combined text of obstetrics and gynecology prepared primarily for undergraduates, with the supplementary hope that it will be useful to more advanced students of this discipline. It aims to give the student a basic survey of both sectors of the field from the vantage point of a single author, and it often succeeds in this difficult task. The complexities of modern physiological advances have diminished the authority of single-authored texts in many areas of knowledge, for no single person can encompass them all, no matter what his scholarly distinction. Nonetheless, as a basic work in the traditional format, this book must be considered successful. About one third of the text is devoted to gynecology and the other two thirds to obstetrics. It is illustrated rather meagerly with line drawings that lack detail and sparkle, except in the case of diagnostic diagrams which are very
Protease-Activated Receptor-2 Regulates the Innate Immune Response to Viral Infection in a Coxsackievirus B3–Induced Myocarditis
Authors: Alice Weithauser, Peter Bobbert, Silvio Antoniak, Andreas Böhm, Bernhard H. Rauch, Karin Klingel, Konstantinos Savvatis, Heyo K. Kroemer, Carsten Tschope, Andrea Stroux, Heinz Zeichhardt, Wolfgang Poller, Nigel Mackman, Heinz-Peter Schultheiss, Ursula Rauch
Journal: Journal of the American College of Cardiology (2013)
PRESENT STATUS OF THE UROLOGY OF WAR
Authors: EDWARD L. KEYES
Journal: JAMA (1918)

It is the fortune of war that great renown is the lot of those who happen to be among the first of the wounded or the killed. But after these first few the names are lost in numbers. To this rule the members of the Medical Corps and notably of the Medical Reserve Corps of the United States Army have been a glorious exception. They were literally the first at the front, they were the first to shed their blood for their country. Hundreds of them were sent silently to the support of the British as early as May and June of last year, and from that time to this they have paid their toll of dead and wounded—they have been gassed, they have suffered the interminable daily hardships of mud and privation, of gas and shell fire. Their valiant action, their fidelity to duty are unrecorded. We may well
Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial
Authors: Mitesh Patel, Janine Pilcher, Alison Pritchard, Kyle Perrin, Justin Travers, Dominick Shaw, Shaun Holt, Matire Harwood, Peter Black, Mark Weatherall, Richard Beasley
Journal: The Lancet Respiratory Medicine (2013)
Practical Orthopaedic Sports Medicine and Arthroscopy
Authors: Michael A. Terry
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TGF-β Cytokine Signaling Promotes CD8+ T Cell Development and Low-Affinity CD4+ T Cell Homeostasis by Regulation of Interleukin-7 Receptor α Expression
Authors: Weiming Ouyang, Soyoung A. Oh, Qian Ma, Michael R. Bivona, Jinfang Zhu, Ming O. Li
Journal: Immunity (2013)
Introduction to Neuropathology
Authors: Orville T. Bailey
Journal: JAMA (1969)

This book is designed for use in a medical school course in neuropathology. About equal space is devoted to brief discussions of a wide variety of neurologic conditions and to an atlas illustrating them. It is planned for a course which has 20 or more lecture-laboratory periods, such as exists at Harvard Medical School but at few others. The presentation of topics is largely from the morphologic approach, with some emphasis on clinicopathologic correlation. It is assumed that the bones of the text will be given flesh and sinew by lectures and by laboratory study. Treatment of individual conditions is superficial even from the purely structural viewpoint, and the occasional excursions into neurophysiology and chemistry are even more so. One surprising omission is a bibliography, for surely one prime function of a teaching manual is to stimulate the student to use primary sources. It is a considerable advantage for a
Salt Wasting and Deafness Resulting from Mutations in Two Chloride Channels
Authors: Karl P. Schlingmann, Martin Konrad, Nikola Jeck, Petra Waldegger, Stephan C. Reinalter, Martin Holder, Hannsjörg W. Seyberth, Siegfried Waldegger
Journal: New England Journal of Medicine (2004)

Mutations in genes encoding chloride transporters cause Bartter's syndrome. An antenatal form associated with salt wasting and deafness has been observed in persons with mutations in BSND, the gene...
RENAL EFFECT OF CARPERITIDE AND NICORANDIL IN TREATMENT OF ACUTE HEART FAILURE SYNDROMES WITH CHRONIC KIDNEY DISEASE
Authors: Akihiro Kawamura, Keishi Moriwaki, Kiyotaka Watanabe, Takeshi Takamura, Takashi Omura, Tetsuya Seko, Atsunobu Kasai, Masaaki Itoh, Hiroshi Yokoe, Hirofumi Maeba, Fumio Yuasa, Toshiji Iwasaka
Journal: Journal of the American College of Cardiology (2011)