Losartan for Microalbuminuria in Normotensive Type 2 Diabetes Mellitus
Authors: Kazuomi Kario
Journal: Annals of Internal Medicine (2004)

Letters20 April 2004Losartan for Microalbuminuria in Normotensive Type 2 Diabetes MellitusKazuomi Kario, MD, PhD and Kazuyuki Shimada, MD, PhDKazuomi Kario, MD, PhDFrom Jichi Medical School, Tochigi 329-0498, Japan.Search for more papers by this author and Kazuyuki Shimada, MD, PhDFrom Jichi Medical School, Tochigi 329-0498, Japan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-8-200404200-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Zandbergen and colleagues reported that an angiotensin-receptor antagonist, losartan, reduced urinary albumin excretion in normotensive patients with type 2 diabetes mellitus, independent of the blood pressure-lowering effect (1). However, before such conclusions can be drawn, information about ambulatory blood pressure is necessary.Nondipping nocturnal blood pressure, an independent cardiovascular risk factor (2), is closely associated with microalbuminuria regardless of usual blood pressure level. A recent study has shown that nondipping nocturnal blood pressure precedes microalbuminuria in normotensive diabetic patients (3). Thus, reduction of higher nocturnal blood pressure in normotensive diabetic patients with nondipping nocturnal blood pressure may ...References1. Zandbergen AA, Baggen MG, Lamberts SW, Bootsma AH, de Zeeuw D, Ouwendijk RJ. Effect of losartan on microalbuminuria in normotensive patients with type 2 diabetes mellitus. A randomized clinical trial. Ann Intern Med. 2003;139:90-6. [PMID: 12859158] LinkGoogle Scholar2. Kario K, Shimada K, Pickering TG. Abnormal nocturnal blood pressure falls in elderly hypertension: clinical significance and determinants. J Cardiovasc Pharmacol. 2003;41 Suppl 1 S61-6. [PMID: 12688399] MedlineGoogle Scholar3. Lurbe E, Redon J, Kesani A, Pascual JM, Tacons J, Alvarez V, et al . Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes. N Engl J Med. 2002;347:797-805. [PMID: 12226150] CrossrefMedlineGoogle Scholar4. Marfella R, Esposito K, Giugliano D. Increase in nocturnal blood pressure and progression to microalbuminuria in diabetes [Letter]. N Engl J Med. 2003;348:260-4. [PMID: 12530443] CrossrefMedlineGoogle Scholar5. Kario K, Pickering TG, Umeda Y, Hoshide S, Hoshide Y, Morinari M, et al . Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study. Circulation. 2003;107:1401-6. [PMID: 12642361] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Jichi Medical School, Tochigi 329-0498, Japan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Losartan on Microalbuminuria in Normotensive Patients with Type 2 Diabetes Mellitus Adrienne A.M. Zandbergen , Marinus G.A. Baggen , Steven W.J. Lamberts , Aart H. Bootsma , Dick de Zeeuw , and Rob J.Th. Ouwendijk Losartan for Microalbuminuria in Normotensive Type 2 Diabetes Mellitus Adrienne A.M. Zandbergen , Marinus G.A. Baggen , and Rob J.Th. Ouwendijk Losartan for Microalbuminuria in Normotensive Type 2 Diabetes Mellitus Anil K. Mandal Metrics 20 April 2004Volume 140, Issue 8Page: 668KeywordsAlbuminsBloodBlood pressureExcretionMedical risk factorsMicroalbuminuriaProspective studiesType 2 diabetes ePublished: 20 April 2004 Issue Published: 20 April 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...