tbuckley/cabot-search huggingface dataset:
Neonatal innate cytokine responses to BCG controlling T-cell development vary between populations
Authors: Anita H.J. van den Biggelaar, Susan L. Prescott, Marjut Roponen, Marie A. Nadal-Sims, Catherine J. Devitt, Suparat Phuanukoonnon, William Pomat, Meri K. Tulic, Deborah Lehmann, Peter M. Siba, Peter C. Richmond, Patrick G. Holt
Journal: Journal of Allergy and Clinical Immunology (2009)
Role of positron emission tomography in the investigation of human coronary circulatory function
Authors: R. D. Silva, P. G Camici
Journal: Cardiovascular Research (1994)

Journal Article Role of positron emission tomography in the investigation of human coronary circulatory function Get access Ranil De Silva, Ranil De Silva Cyclotron Unit, MRC Clinical Sciences Centre, Hammersmith Hospital and Royal Postgraduate Medical School, Du Cane Road, London W12 0HS, United Kingdom: R de Silva, P G Camici. Correspondence to Dr Camici. Search for other works by this author on: Oxford Academic PubMed Google Scholar Paolo G Camici Paolo G Camici Cyclotron Unit, MRC Clinical Sciences Centre, Hammersmith Hospital and Royal Postgraduate Medical School, Du Cane Road, London W12 0HS, United Kingdom: R de Silva, P G Camici. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 11, November 1994, Pages 1595–1612, https://doi.org/10.1093/cvr/28.11.1595 Published: 01 November 1994 Article history Received: 13 April 1994 Accepted: 20 June 1994 Published: 01 November 1994
[405] RIBOSOMAL PROTEINS OVER-EXPRESSED IN HBV-ASSOCIATED HEPATOCELLULAR CARCINOMA UPREGULATE THE HBx-INDUCED NF-icB SIGNALING
Authors: K.H. Lim, B.L. Seong, S.Y. Kwon, W.H. Choe, S.H. Ahn, K.H. Han, C.H. Lee, K.H. Kim
Journal: Journal of Hepatology (2007)
Endothelial Nitric Oxide Synthase Regulates T Cell Receptor Signaling at the Immunological Synapse
Authors: Sales Ibiza, Víctor M. Víctor, Irene Boscá, Angel Ortega, Ana Urzainqui, José E. O'Connor, Francisco Sánchez-Madrid, Juan V. Esplugues, Juan M. Serrador
Journal: Immunity (2006)
Clinical Practice and Physiology of Artificial Respiration.
Authors: John B. Stetson
Journal: JAMA (1963)

In 1939, Lord Nuffield provided an "iron lung" to every hospital in the commonwealth which requested one. The Nuffield Department of Anaesthetics, established at Oxford in 1937, helped distribute these machines and gave instructions in their use. As early as 1940, work began on the use of these respirators in the prophylaxis of chest complications after operation. In 1947, Dr. Ritchie Russell began using respirator treatment for patients with poliomyelitis. Using the tracheotomy and intermittent positive pressure respiration method of treatment, Dr. Russell established a respirator unit at Oxford in 1953. He stimulated an association between Drs. Spalding and Smith to carry on this work; in 1955 Lord Nuffield generously provided a six-bed ward where, as of publication time, the authors have treated 153 patients. The book, based on this experience, may be divided into three main sections, the practice, the physiology, and use of artificial respiration in specific diseases.
Thrombotic thrombocytopenic purpura in pulmonary-renal syndromes
Authors: Nicki Panoskaltsis, Melanie P. Derman, Irene Perillo, James K. Brennan
Journal: American Journal of Hematology (2000)

Thrombotic thrombocytopenic purpura pathologically consists of a thrombotic microangiopathy that classically spares lung tissues. We describe a case of TTP that presented as a pulmonary-renal syndrome. In reviewing the international literature, pulmonary involvement is not as rare as once was thought, and the diagnosis of TTP should be considered in the differential diagnosis of pulmonary-renal syndromes.
BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis
Authors: Felix Sahm, David Capper, Matthias Preusser, Jochen Meyer, Albrecht Stenzinger, Felix Lasitschka, Anna-Sophie Berghoff, Antje Habel, Marion Schneider, Andreas Kulozik, Ioannis Anagnostopoulos, Leonhard Müllauer, Gunhild Mechtersheimer, Andreas von Deimling
Journal: Blood (2012)
Decreased tobacco-glycoprotein-induced lymphocyte proliferation in vitro in pulmonary eosinophilic granuloma.
Authors: L H Youkeles, J N Grizzanti, Z Liao, C J Chang, D L Rosenstreich
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Pulmonary eosinophilic granuloma is a disorder caused by localized collections of proliferating histiocytes in the lung. Little is known about its etiology except that the majority (58 to 97%) of patients are current or ex-smokers, making the potential etiologic role of tobacco products an important area for research. Tobacco glycoprotein (TGP) is a potent immunostimulator that has been isolated from cigarette smoke. TGP-specific lymphocyte proliferation, and cytokine production in vitro, were measured in three patients with pulmonary eosinophilic granuloma in remission and in three closely matched normal subjects with similar smoking histories. One patient with eosinophilic granuloma of bone and a matched control subject were also studied. Peripheral blood mononuclear cells were cultured with TGP, the recall antigen streptokinase (SK), and the mitogen concanavalin A (Con A). All three of the patients with pulmonary eosinophilic granuloma exhibited significant decreases in lymphocyte stimulation to TGP, despite normal responses to SK and Con A. In contrast, the response of the patient with eosinophilic granuloma of bone was higher than her matched control. The mean responses of the patients with pulmonary eosinophilic granuloma to TGP was significantly lower than the mean of nondiseased smokers or of normal nonsmokers. Twenty-four-hour culture supernatants were collected and assayed for cytokine levels (IL-1, IL-2, and IL-6). TGP-stimulated IL-2 production was significantly lower in the patients with pulmonary eosinophilic granuloma than in the normal subjects, confirming the reduced T-cell proliferative response.(ABSTRACT TRUNCATED AT 250 WORDS)
Inhaled Corticosteroids for Young Children with Wheezing
Authors: Diane R. Gold, Anne L. Fuhlbrigge
Journal: New England Journal of Medicine (2006)

In the Childhood Asthma Management Program study of school-aged children with established mild-to-moderate persistent asthma, twice-daily therapy with inhaled corticosteroids controlled symptoms of asthma but slightly reduced height growth and did not improve lung growth or affect the natural course of the disease.1 In this issue of the Journal, two studies involving young children2,3 test the hypothesis that the natural history of wheezing in early life may be altered by the administration of continuous or intermittent doses of inhaled corticosteroids when symptoms first occur but when the diagnosis of asthma is still uncertain. Both groups of authors conclude that . . .
Prevalence of the Trp64Arg missense mutation of the β3-adrenergic receptor gene in Japanese subjects
Authors: Kohei Ueda, Yukio Tanizawa, Yasuharu Oota, Hirohumi Inoue, Nobuaki Kizuki, Hiroshi Inoue, Katsunori Tsukuda, Tomoichiro Asano, Yoshitomo Oka
Journal: Metabolism (1997)
The Liver in Crigler-Najjar Syndrome, Protoporphyria, and Other Metabolic Disorders
Authors: Joseph R. Bloomer, Harvey L. Sharp
Journal: Hepatology (1984)

The liver may be involved in metabolic disorders in two ways, (i) Due to its critical role in several metabolic pathways, the liver may be the major site of expression of a biochemical abnormality. For example, in Type I Crigler-Najjar syndrome, absence of hepatic bilirubin glucuronyl transferase activity causes severe unconjugated hyperbilirubinemia which invariably leads to death from kernicterus. (ii) The liver may also be structurally damaged by the metabolic disorder. Several patients with protoporphyria have died in hepatic failure due to liver damage caused by protoporphyrin deposition. Numerous other metabolic disorders can be sited in which significant liver involvement occurs. In many of these disorders, there is no effective medical therapy.
Tempering or Tampering
Authors: Zev W. Chayes
Journal: JAMA (1977)

To the Editor.—  The letter by Drs Teigs and Mishkin (237:644, 1977) suggesting that the use of bone scans as  screening procedure for metastasis should be tempered by the clinical examination merits rebuttal.  There is no disagreement that nuclear medicine procedures and laboratory tests in general may be overused to the point of abuse. It would be well if all physicians requesting these studies would be guided by some specific criteria. We could suggest two: (1) the test is requested in order that its results be applied directly to the management of the particular patient; (2) the test is necessary to study the natural course of  disease to guide the clinical care of other patients with  similar disease. Too often consultations and laboratory studies are requested just for the record.  However, the main thrust of their letter is that a bone scan... in patients with proved carcinomas...
922 NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) OF NON-OBESE DIABETES: PREVALENCE AND RELATIONSHIPS WITH DOPPLER HEMODYNAMIC ALTERATIONS, LEPTIN, INFLAMMATION AND OXIDATIVE STRESS
Authors: S. Gaiani, A. Avogaro, G.C. Bombonato, M. Bolognesi, B. Conte, S. De Kreutzenberg, G. Guarneri, P. Pontisso, A. Gatta, D. Sacerdoti
Journal: Journal of Hepatology (2008)
P135Sulfur dioxide derivative prevents isoproterenol induced electrophysiological alterations
Authors: N Yaras, S Ozdemir, U Dalaman, H Ozdogan
Journal: Cardiovascular Research (2014)

Excitation-contraction coupling in cardiac muscle of hypertrophic cardiomyopathy (HCM) remains poorly understood, despite the fact that the genetic alterations are well defined. In this sense, many intracellular signaling molecules and pathways has been tested. Among these, the most interesting ones are carbon monoxide (CO), nitrogen monoxide (NO) and hydrogen sulfide (H2S) referred to as the gasotransmitters. These molecules have been identified primarly as contaminants of the environment. In addition to these substances, sulfur dioxide (SO2) is the one that still investigated in the same way. Recent studies regarding the heart muscle beside other organs, SO2 is endogenously produced and possible intercellular signaling molecule. However, the influence on heart′s electrical and mechanical functions is unknown. This study was designed to uncover the potential role of SO2 in rat model of HCM generated by excessive β-adrenergic stimulation was used. Single cells have been obtained by enzymatically from hearts of wistar rats given β-adrenergic agonist isoproterenol (25 mg per kg body weight per day) subcutaneously to generate HCM and/or SO2 donor sodium metabisulfite (85 mg per kg body weight per day) for 7 days (i.p). It has been found that SO2 had no effect on isoproterenol induced hypertrophy via examining heart weight/tibia length ratio. It is observed that lengthening at repolarization phase of action potential in the animal model and SO2 application reversed this process. Moreover, isoproterenol treatment reduced L-type Ca2+ current, it was returned to control levels by application of SO2. Experimental HCM model leads to adverse changes in mechanical parameters, even though SO2 causes improvement in the electrophysiological parameters. Also shortening in the resting sarcomere length along with decreasing contraction amplitude in isoproterenol and SO2 applied animals would interpret diastolic dysfunction due to increased Ca2+ sensitivity. Also isoproterenol induced cardiac damage were not caused by oxidation since no difference observed on protein oxidation and lipid peroxidation measurements. However, it is determined that SO2 application alone does increase protein carbonyl values. In this context, while SO2 molecule creates oxidative stress in physiological condition, different effects on the organism can be revealed depending on the physiological conditions. Consequently, the data have implied that SO2 molecule has possible effect on cardiovascular system pathology and on electrophysiology of heart. In order to fully understand of this effect, detailed studies are required.
Influence of protein composition and hydrolysis method on intestinal absorption of protein in man.
Authors: P P Keohane, G K Grimble, B Brown, R C Spiller, D B Silk
Journal: Gut (1985)

An intestinal perfusion technique has been used in normal human subjects to investigate the influence that starter protein composition and hydrolysis procedure have on absorption of amino acid residues from partial enzymic hydrolysates of whole protein. Five starter proteins were studied. Three (egg albumin, casein/soy/lactalbumin, and lactalbumin) were hydrolysed by papain, a second lactalbumin starter protein, and a meat/soy/lactalbumin blend were hydrolysed by a porcine pancreatic enzyme system. Irrespective of starter protein composition or hydrolysis method used, four amino acid residues (threonine, glutamic acid, phenylalanine, and histidine) were absorbed significantly faster from all hydrolysates compared with absorption from their equivalent free amino acid mixtures. In contrast, both starter protein composition and hydrolysis method influenced absorption characteristics of up to nine other amino acid residues.
Degenerative Disease of the Central Nervous System in New Guinea
Authors: D. C. Gajdusek, V. Zigas
Journal: New England Journal of Medicine (1957)

DURING the past two years' service as medical officer of the Kainantu Sub-District, Eastern Highlands of the Australian Trust Territory of New Guinea, one of us (V.Z.) has had the opportunity of observing in the inhabitants of the mountain-dissected highlands some 30 to 50 miles southeast of Kainantu (Fig. 1) an unusually high incidence of a syndrome similar to paralysis agitans affecting children and adults, predominantly females, in natives of the recently controlled Forei linguistic and cultural group and in their neighbors of the Keiagana, Kanite, Kimi, Usurufa and Auiyana linguistic groups. During the past three months an intensive clinicopathological . . .
P193 Assessment of performance status in lung cancer: do oncologists and respiratory physicians agree?
Authors: C. Addy, J. Suntharalingam, E. De Winton, V. Masani, G. Taylor
Journal: Thorax (2011)

<h3>Introduction and Objectives</h3> Performance status assessment in lung cancer patients is essential to assess prognosis and plan management. Inter observer variability has been documented between oncologists, their patients and other professionals (Blagden <i>et al</i> 2003). No study has previously examined whether this variability also exists between respiratory physicians and oncologists. We hypothesised that performance status assessment would vary between respiratory physicians and oncologists. We also questioned whether frequency of outpatient contact with lung cancer patients or stage of training affected assessment. <h3>Methods</h3> 8 case vignettes were sent to respiratory physicians, oncologists and speciality trainees using an online survey tool. The speciality, seniority and frequency of outpatient contact were recorded. The Eastern Co-operative Oncology Group Score (ECOG) was used due to greater familiarity and increased inter-observer reliability in previous studies. <h3>Results</h3> 119 respondents completed the survey—62% were oncologists. 85% of respondents were consultants and 62% reviewed patients frequently (weekly) in outpatients. 20% saw lung cancer patients rarely or never. Individual assessments were broad, with seven case vignettes receiving 3 or more performance status (PS) ratings. 6 cases crossed the theurapeutic boundary between PS 2 and PS 3. In one case assessment ranged from PS 0 to PS 4. However, Krippendorfs α assessment (K α) (Hayes and Krippendorf, 2007) showed overall agreement at 0.59. This confirmed wide individual variation but closer group agreement. There was no difference in assessment between oncologists and respiratory physicians—K α 0.61 and 0.63 respectively. Equal K α values of 0.62 between Speciality trainees and Consultants showed stage of training had no impact. Frequency of review did not affect level of agreement with K α values of 0.62 and 0.64 for frequent reviewers vs non-frequent. <h3>Conclusions</h3> Rating of performance status varies widely between individuals. This may negatively affect patients if only individual assessment is performed. However, respiratory physicians and oncologists exhibit statistically significant agreement in their assessments. This is not affected by stage of training or frequency of outpatient contact. This study highlights that review of performance status across specialities or by multiple assessors (The MDT) is likely to lead to more consistent assessment.
Disciplining hospital consultants
Authors: W. Savage
Journal: BMJ (1989)

Finally, we believe that the patient's interests are best served by having operations performed by surgeons who are suitably experienced in the particular disorder and operation concerned: their official specialty is secondary and the surgeon best satisfying these criteria currently varies from region to region.It is noteworthy that, although in the United Kingdom no specialist qualification in head and neck surgery exists, the FRCS (Otolaryngology) emphasises the subject more than its general counterpart.
Payment to help quit smoking "works," says study
Authors: B. Christie,
Journal: BMJ (2012)

A scheme that offers a payment of £12.50 (€15; $20) a week to encourage people living in deprived circumstances to give up smoking is being hailed a success.

A two year evaluation of the quit4u programme in Dundee concludes that it “offers an effective model for engaging and supporting smokers in deprived areas to quit.”

When the scheme was launched in 2009, it was hoped that half of those who took part would give up.1 At one month, the quit rate was 50% compared with 33.7 % for other …
Genetic Ablation of the <i>Bmpr2</i> Gene in Pulmonary Endothelium Is Sufficient to Predispose to Pulmonary Arterial Hypertension
Authors: Kwon-Ho Hong, Young Jae Lee, Eunji Lee, Sung Ok Park, Chul Han, Hideyuki Beppu, En Li, Mohan K. Raizada, Kenneth D. Bloch, S. Paul Oh
Journal: Circulation (2008)

Pulmonary arterial hypertension (PAH) is a rare but fatal lung disease of diverse origins. PAH is now further subclassified as idiopathic PAH, familial PAH, and associated PAH varieties. Heterozygous mutations in BMPR2 can be detected in 50% to 70% of patients with familial PAH and 10% to 40% of patients with idiopathic PAH. Although endothelial cells have been suspected as the cellular origin of PAH pathogenesis, no direct in vivo evidence has been clearly presented. The present study was designed to investigate whether endothelial Bmpr2 deletion can predispose to PAH.The Bmpr2 gene was deleted in pulmonary endothelial cells using Bmpr2 conditional knockout mice and a novel endothelial Cre transgenic mouse line. Wide ranges of right ventricular systolic pressure were observed in mice with heterozygous (21.7 to 44.1 mm Hg; median, 23.7 mm Hg) and homozygous (20.7 to 56.3 mm Hg; median, 27 mm Hg) conditional deletion of Bmpr2 in pulmonary endothelial cells compared with control mice (19.9 to 26.7 mm Hg; median, 23 mm Hg) at 2 to 7 months of age. A subset of mice with right ventricular systolic pressure >30 mm Hg exhibited right ventricular hypertrophy and an increase in the number and wall thickness of muscularized distal pulmonary arteries. In the lungs of these mice with high right ventricular systolic pressure, the expression of proteins involved in the pathogenesis of PAH such as serotonin transporter and tenascin-C was elevated in distal arteries and had a high incidence of perivascular leukocyte infiltration and in situ thrombosis.Conditional heterozygous or homozygous Bmpr2 deletion in pulmonary endothelial cells predisposes mice to develop PAH.
Prediction of Life-Threatening Arrhythmic Events in Patients With Chronic Myocardial Infarction by Contrast-Enhanced CMR
Authors: Philipp Boyé, Hassan Abdel-Aty, Udo Zacharzowsky, Steffen Bohl, Carsten Schwenke, Rob J. van der Geest, Rainer Dietz, Alexander Schirdewan, Jeanette Schulz-Menger
Journal: JACC. Cardiovascular imaging (2011)
Sensitivity and specificity of QRS duration to predict acute benefit in heart failure patients with ventricular resynchronization
Authors: V. Kadhiresan, J. Vogt, A. Auricchio, C. Butter, C. Stellbrink, A. Kramer, J. Spinelli, J. Ding, L. Liu, A. Doelger
Journal: European Journal of Heart Failure (2000)
Relationship Between CCR5 Density and Viral Load After Discontinuation of Antiretroviral Therapy
Authors: J. Reynes
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peripheral Venous Blood Gases
Authors: Donal D. O'Sullivan
Journal: JAMA (1971)

<h3>To the Editor. —</h3> In QUESTIONS AND ANSWERS (<b>216</b>:1042, 1971), the source of blood samples for blood gas studies was discussed by five correspondents. Arterialized venous blood and peripheral venous blood for blood gas studies were discussed. One of the correspondents, Dr. Peretz, indicated that he knew of no data on peripheral venous samples. Such information is reported by Gambino, Weisberg, and others. For some time we have run simultaneous peripheral venous specimens in conjunction with each arterial puncture specimen from patients, predominantly from our intensive and coronary care units. These data demonstrate that for acid-base studies peripheral venous specimens are completely adequate regardless of patient condition as to shock. We have found, as expected, that for blood oxygen values the arterial samples are far more consistent with clinical condition than are venous samples. However, we have also found that once venous levels of oxygen pressure (Po<sub>2</sub>) are
Book Review Disease Control Priorities in Developing Countries Second edition. Edited by Dean T. Jamison, Joel G. Breman, Anthony R. Measham, and others. 1401 pp., illustrated. New York, World Bank/Oxford University Press, 2006. $125. 0-8213-6179-1 (The entire book is available online and free of charge at www.dcp2.org/page/main/Home.html.)
Authors: Roger Glass
Journal: New England Journal of Medicine (2006)