Optimal Duration of Treatment of Chronic Urinary Tract Infection
Authors: MARVIN TURCK
Journal: Annals of Internal Medicine (1968)

Editorials1 October 1968Optimal Duration of Treatment of Chronic Urinary Tract InfectionMARVIN TURCK, M.D., F.A.C.P., ROBERT G. PETERSDORF, M.D., F.A.C.P.MARVIN TURCK, M.D., F.A.C.P.Search for more papers by this author, ROBERT G. PETERSDORF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-4-837 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChronic urinary tract infections are often refractory to antimicrobial therapy or recur after cessation of treatment. The paucity of cures in these patients, even after prolonged drug therapy, may be related to factors other than the specific antimicrobial agent used. Among the possible reasons for this are failure to remedy obstruction to urine flow; renal calculi with persistence of infection; emergence of antibiotic resistant mutants during treatment; presence of "mixed infections" in which only the sensitive pathogens are eliminated with persistence of resistant strains; a milieu unfavorable to optimal action of antibiotics within the renal parenchyma; or the possibility that...References1. LINDEMEYER RI, TURCK M, and PETERSDORF RG: Factors determining the outcome of chemotherapy in infections of the urinary tract. Ann. Intern. Med. 58: 201, 1963. LinkGoogle Scholar2. KLEEMAN CR, HEWITT WL, and GUZE LB: Pyelonephritis. Medicine (Balt.) 39: 3, 1960. MedlineGoogle Scholar3. STANSFELD JM and WEBB JK: Plea for longer treatment of chronic pyelonephritis in children. Brit. Med. J. 1: 616, 1954. CrossrefMedlineGoogle Scholar4. TAYLOR RD: Diagnosis and treatment of pyelonephritis. Med. Clin. North Amer. 40: 957, 1955. CrossrefGoogle Scholar5. BIRCHALL R and ALEXANDER JE: Medical aspects of pyelonephritis. Medicine (Balt.) 29: 1, 1950. CrossrefMedlineGoogle Scholar6. GRIEBLE HG and JACKSON GG: Prolonged treatment of urinary tract infections with sulfamethoxypyridazine. New Eng. J. Med. 258: 1, 1958. CrossrefMedlineGoogle Scholar7. TURCK M, BROWDER AA, LINDEMEYER RI, BROWN NK, ANDERSON KN, and PETERSDORF RG: Failure of prolonged treatment of chronic urinary-tract infections with antibiotics. New Eng. J. Med. 267: 999, 1962. CrossrefMedlineGoogle Scholar8. TURCK M, ANDERSON KN, and PETERSDORF RG: Relapse and reinfection in chronic bacteriuria. New Eng. J. Med. 275: 70, 1966. CrossrefMedlineGoogle Scholar9. KUNIN CM: Microbial persistence versus reinfection in recurrent urinary tract infections, in Antimicrobial Agents and Chemotherapy—1962, Braun-Brumfield, Inc., Ann Arbor, Mich., 1963, pp. 21-25. Google Scholar10. MCCABE WR and JACKSON GG: Treatment of pyelonephritis: bacterial, drug and host factors in success or failure among 252 patients. New Eng. J. Med. 272: 1037, 1965. CrossrefGoogle Scholar11. TURCK M, RONALD A, and PETERSDORF RG: Relapse and reinfection in chronic bacteriuria. II. The correlation between site of infection and pattern of recurrence in chronic bacteriuria. New Eng. J. Med. 278: 422, 1968. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARVIN TURCK, M.D., F.A.C.P.; ROBERT G. PETERSDORF, M.D., F.A.C.P.Affiliations: Department of Medicine University of Washington Seattle, Wash. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTime courses of bacterial density in urine during antibacterial chemotherapy and influential factors in patients having positive bacteriuria with a complicated urinary tractOne or Three Weeks' Treatment of Acute Pyelonephritis?: A Double-blind Comparison, Using a Fixed Combination of Pivampicillin Plus PivmecillinamCystitis and pyelonephritisDuration of treatment of urinary tract infectionsBladder versus renal bacteriuria during pregnancy: Recurrence after treatmentEffective treatment of urinary tract infectionsIDENTIFICATION OF SITE OF URINARY-TRACT INFECTIONS BY ANTIBODY-COATED BACTERIA ASSAYTherapy of Recurrent Invasive Urinary-Tract Infections of MenFive-day course of antibacterials for uncomplicated urinary infectionsLong-Term Therapy of Urinary Tract InfectionsCALVIN M. KUNIN, M.D.Localization of Urinary-Tract Infections by Detection of Antibody-Coated Bacteria in Urine SedimentExtended Therapy with a Trimethoprim-Sulphonamide for the Treatment of Established Urinary Tract InfectionExtended Therapy in Patients with Established Urinary Tract InfectionEpidemiologic Aspects of Postoperative Sepsis in a Urologic Practice (with a Note Concerning Antibacterial Prophylaxis)The Natural History of Recurrent Bacteriuria in Schoolgirls 1 October 1968Volume 69, Issue 4Page: 837-839KeywordsAntibioticsAntimicrobialsDrug therapyKidney stonesPathogensUrine ePublished: 1 December 2008 Issue Published: 1 October 1968 PDF downloadLoading ...