tbuckley/cabot-search huggingface dataset:
Is killing the pain worth the risk?
Authors: Rebecca Coombes
Journal: BMJ (2007)

<h3>Abstract</h3> Great progress in sequencing technologies and computational biology suggests that the noncoding sequence in mammalian genome is rich in functional elements to produce proteins. Many RNA molecules, mis-annotated as noncoding, actually harbor small open reading frames that are predicted to code proteins called micropeptides. Some micropeptides have been discovered and verified to play critical roles in multiple biological processes. Lipid droplet (LD) is a unique cellular organelle, conserved from bacteria to humans, and closely associated with cellular lipid metabolism and metabolic disorders. However, no micropeptide has been identified on LDs. Here we for the first time explore this possibility. Proteins with small molecular weight from isolated LDs of myoblasts were enriched by electrophoresis and subjected to proteomic analysis, and LD-associated micropeptides (LDAMP) were identified using mass spectrometry coupled with a home-made protein database. A total of 15 micropeptides were identified. One of them was studied further and termed LDAMP1. Similar to LD resident proteins, LDAMP1 was degraded by proteasome. LDAMP1 was localized on LDs by confocal imaging, cell fractionation, as well as immunogold labeling. Using CRISPR/Cas9-mediated genome editing technique, endogenous expression of LDAMP1 was validated by FLAG tag knock-in. Moreover, oleate-induced triacylglycerol accumulation was significantly decreased when myoblasts expressing LDAMP1 and, in turn, the rescue of palmitate-inhibited insulin sensitivity was obviously reduced. Taken together, we report for the first time that translatable noncoding RNA-derived peptides were identified on LDs and a novel LD protein LDAMP1was discovered, which paves a new way for exploring LD dynamics and related metabolic functions.
Phenytoin intoxication during treatment with parenteral miconazole.
Authors: P E Rolan, A A Somogyi, M J Drew, W G Cobain, D South, F Bochner
Journal: BMJ (1983)

ORT REPORTS Phenytoin intoxication during treatment with parenteral miconazoleWe describe a patient in whom phenytoin toxicity developed soon after treatment with parenteral miconazole.
PTH-159 Group Education is as Effective as one-to-one Sessions when Administering the Low Fodmap Diet in Functional Bowel Disorders
Authors: T Joyce, H M Staudacher, K Whelan, P M Irving, M C Lomer
Journal: Gut (2013)

<h3>Introduction</h3> The low FODMAP diet is an effective intervention for people with functional bowel disorders (FBD). It has been introduced successfully to the UK with &gt; 250 dietitians trained in its implementation. However, teaching patients about the diet is labour intensive; initial appointments typically last one hour. Given the prevalence of FBD, this represents a significant obstacle to widespread use. Group education sessions (GS) are a possible solution and are effective for dietary interventions in other disorders (e.g. diabetes, obesity), although their effectiveness has not been established for the low FODMAP diet. We aimed to compare the effectiveness of GS with one-to-one sessions (OS). <h3>Methods</h3> Patients referred in 2011–12 with FBD were pre-assessed by telephone to confirm suitability for GS. Those with atypical symptoms or with other medical or nutritional concerns were excluded. Suitable patients were offered the choice of GS or OS. Up to 12 patients were seen in each GS lasting 1.5h and were then followed up 6–10 weeks later in a 1h GS. Patients seen in OS had an initial 1h appointment and then a 0.33h follow-up, 6–10 weeks later. Effectiveness of the diet was compared in OS and GS. Symptoms were measured using the gastrointestinal symptom rating scale at baseline and follow-up and clinical effectiveness through the global symptom question (GSQ). Comparisons were made using the χ2 test. Acceptability of GS sessions was also assessed. <h3>Results</h3> Data from 168 patients attending GS (70% female, mean age 39y) were compared with 50 patients attending OS (60% female, mean age 47y). Positive responses to the GSQ ‘do you currently have satisfactory relief of your gut symptoms’ improved from 30/155 (19%) at baseline to 71/146 (49%) in the GS (P &lt; 0.001) and from 2/45 (4%) to 23/44 (52%) in the OS patients (P = 0.016). Proportion of those with adequate control at follow up was not significantly different between OS and GS (P = 0.895). At follow up, 94% of GS patients reported adherence to the diet &gt; 50% of the time. Most of the GS patients felt length of the sessions (95%), content (93%) and balance between education and patient involvement (95%) were ‘just right’. In retrospect, 39% would have preferred OS, with the remainder preferring GS or expressing no preference. <h3>Conclusion</h3> GS are an effective medium for instructing patients in the implementation of the low FODMAP diet. Whilst a significant minority attending GS would have preferred OS, there are several possible advantages to GS including peer-support and sharing of experiences. Most importantly, GS allow increased capacity and shorter waiting times. <h3>Disclosure of Interest</h3> None Declared.
Specific Recognition and Killing of Glioblastoma Multiforme by Interleukin 13-Zetakine Redirected Cytolytic T Cells
Authors: Kanwarpal S. Kahlon, Christine Brown, Laurence J. N. Cooper, Andrew Raubitschek, Stephen J. Forman, Michael C. Jensen
Journal: Cancer Research (2004)

Abstract The interleukin (IL) 13 receptor α2 (IL13Rα2) is a glioma-restricted cell-surface epitope not otherwise detected within the central nervous system. Here, we describe a novel approach for targeting glioblastoma multiforme (GBM) with IL13Rα2-specific cytolytic T cells (CTLs) by their genetic modification to express a membrane-tethered IL13 cytokine chimeric T-cell antigen receptor, or zetakine. Our prototype zetakine incorporates an IL13 E13Y mutein for selective binding to IL13Rα2. Human IL13-zetakine+CD8+ CTL transfectants display IL13Rα2-specific antitumor effector function including tumor cell cytolysis, TC1 cytokine production, and zetakine-regulated autocrine proliferation. The E13Y amino acid substitution of the IL13 mutein of the zetakine endows CTL transfectants with the capacity to discriminate between IL13Rα2+ GBM targets from targets expressing IL13Rα1. In vivo, the adoptive transfer of IL13-zetakine+CD8+ CTL clones results in the regression of established human glioblastoma orthotopic xenografts. Pilot clinical trials have been initiated to evaluate the feasibility and safety of local-regional delivery of autologous IL13-zetakine redirected CTL clones in patients with recurrent GBM. Our IL13-zetakine is a prototype of a new class of chimeric immunoreceptors that signal through an engineered immune synapse composed of membrane-tethered cytokine muteins bound to cell-surface cytokine receptors on tumors.
Letter by Thum et al Regarding Article, “Oxidant Stress Impairs In Vivo Reendothelialization Capacity of Endothelial Progenitor Cells From Patients With Type 2 Diabetes Mellitus: Restoration by the Peroxisome Proliferator- Activated Receptor-γ Agonist Rosiglitazone”
Authors: Thomas Thum, Johann Bauersachs
Journal: Circulation (2008)
Drug Therapy in Renal Failure: Dosing Guidelines for Adults
Authors: William M. Bennett, Richard S. Muther, Richard A. Parker, Peter Feig, Gail Morrison, Thomas A. Golper, Irwin Singer
Journal: Annals of Internal Medicine (1980)

Data providing guidelines for drug use in adult patients with renal insufficiency are presented in tabular form with supporting references. The data are derived from the current medical literature. If specific information about a drug is unavailable or conflicting, emphasis is given to normal pharmacokinetic variables in arriving at recommendations for therapy. Nephrotoxicity or adverse effects in patients with renal disease are noted and adjustments for dialysis suggested.
Who Should Do Psychotherapy?
Authors: R. Tredgold
Journal: BMJ (1970)

There is a diversity of opinion upon the status of the haematologist.It should, how- ever, be clear that the bulk of laboratory investigations are performed by technicians, whose proficiency at fulfilling routine inves- tigations is far superior to most medical graduates.If the haematologist is to contri- bute more than gratuitous observations of anisocytosis, with a signature to give them authority if not meaning, then he needs the incentive of knowing he has a real job to perform.It is absurd to limit his function to that of an adviser sitting by a desk piled high with journals as the source of his authority.This authority may best come from experience of clinical medicine, labora- tory work, responsibility for treatment, and follow-up.If any one of these components
HOW CAN WE LESSEN THE MORTALITY OF UTERINE CANCER?
Authors: E. E. MONTGOMERY
Journal: JAMA (1907)

The discussion of this subject becomes difficult at its onset because we do not know its cause. The ablest investigators have diligently sought to determine its origin and to lay bare the mystery of its development, but thus far in vain. The inclination of some of the best scientific minds has been to assign a bacteriologic cause, and numerous parasites have been accused of being responsible for its production, but later investigations have not demonstrated their presence as constant. Efforts have been made to associate the various manifestations artefact cell inclusion and cell degeneration with some specific germ, but the apparent discoveries of one have not been substantiated by other observers. The researches of Farmer relating to the existence and separation of the chromatic elements seems to afford an explanation for the origin of the disease in chemical reaction, but whether the impetus be imparted to congenital embryonal cells or
Global Control of Motor Neuron Topography Mediated by the Repressive Actions of a Single Hox Gene
Authors: Heekyung Jung, Julie Lacombe, Esteban O. Mazzoni, Karel F. Liem, Jonathan Grinstein, Shaun Mahony, Debnath Mukhopadhyay, David K. Gifford, Richard A. Young, Kathryn V. Anderson, Hynek Wichterle, Jeremy S. Dasen
Journal: Neuron (2010)
Does play matter? Functional and evolutionary aspects of animal and human play
Authors: Peter K. Smith
Journal: Behavioral and Brain Sciences (1982)

Abstract In this paper I suggest that play is a distinctive behavioural category whose adaptive significance calls for explanation. Play primarily affords juveniles practice toward the exercise of later skills. Its benefits exceed its costs when sufficient practice would otherwise be unlikely or unsafe, as is particularly true with physical skills and socially competitive ones. Manipulative play with objects is a byproduct of increased intelligence, specifically selected for only in a few advanced primates, notably the chimpanzee. The adaptiveness of play in pongid evolution is traced through the probable changes in selective pressures that occurred in hominid evolution. It is argued that fantasy was an emergent property in hominids, made possible by symbolic intelligence and language, and serving to make play complex enough to continue to provide useful practice for increasingly complex later skills. The advent of organised instruction and education has meant that play's unplanned, intrinisic goal-setting could be replaced by extrinsic goal-setting in the systematic development of particular skills. However, the need to ensure adequate motivation has continued to give play educational value. In addition, its capacity to enhance innovative behaviour seems to be a residual function of play which has acquired a new cultural importance.
Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
Authors: Michael Wang, Tom Martin, William Bensinger, Melissa Alsina, David S. Siegel, Edward Kavalerchik, Mei Huang, Robert Z. Orlowski, Ruben Niesvizky
Journal: Blood (2013)
A Home Visit
Authors: Tara Bishop
Journal: Annals of Internal Medicine (2005)

On Being a Doctor18 January 2005A Home VisitTara Bishop, MDTara Bishop, MDFrom Mt. Sinai Hospital, New York, NY 10128.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-2-200501180-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I know that chart. It's the thick one that screams of too many years and problems at the clinic. It has numerous papers falling out because the holes are torn from use. I already know the name that is written on the front cover in large block letters; Mrs. Aranja is back, and my afternoon will be spent fighting over her symptoms and medications.If I recall, she was just here last Wednesday. She had wanted more pain medication because her headaches had become unbearable. They were the throbbing kind that never seemed to go away. She awoke with them ... Author, Article, and Disclosure InformationAffiliations: From Mt. Sinai Hospital, New York, NY 10128.Corresponding Author: Tara Bishop, MD, Mt. Sinai Hospital, One Gustave L. Levy Place, New York, NY 10128; e-mail, tara.[email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCounting People and Recognizing Wheelchairs at Elevator Lobby by Real-Time Image Processing 18 January 2005Volume 142, Issue 2Page: 151-152KeywordsAsthmaBlood pressureChartsCoffeeLower back painNursesPanic disorderStomachUrine ePublished: 18 January 2005 Issue Published: 18 January 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Respiratory symptoms in European animal farmers
Authors: K. Radon, B. Danuser, M. Iversen, R. Jörres, E. Monso, U. Opravil, C. Weber, K.J. Donham, D. Nowak
Journal: European Respiratory Journal (2001)

Farmers are known to be at high risk for the development of occupational airway disease. The aim of this European study was to determine which airway symptoms predominate in different types of animal farmers (cattle, pigs, poultry, sheep) and to compare the prevalence of symptoms to the general population. A total of 6,156 randomly selected animal farmers in Denmark, Germany (Schleswig-Holstein, Niedersachsen), Switzerland, and Spain completed a questionnaire on respiratory symptoms and farming characteristics in 1995–1997. The prevalence of general respiratory symptoms was compared to the results of the European Community Respiratory Health Survey (ECRHS) obtained in the same regions. Pig farmers were at highest risk for the development of work-related symptoms. A significant dose-response relationship between daily hours worked inside animal houses and symptoms was established for pig and poultry farmers. Additionally, self-reported nasal allergies (odds ratio (95% confidence interval): 3.92 (3.26–4.71)) and nasal irritation during work (3.98 (3.35–4.73)) were shown to be associated with the development of chronic phlegm. The prevalence of wheezing, shortness of breath, asthma and nasal allergies was signficantly lower among all farmers in the age group 20–44 yrs than among the general population. However, the prevalence of usually bringing up phlegm in winter among farmers was significantly higher than in the general population (9.4 (8.3–10.5%) versus 7.5 (6.5–8.5%)). Individual factors have been shown to be related to the prevalence of chronic phlegm among farmers. Additionally, this study could support the hypothesis that farming could be negatively related to allergic diseases.
Structure and function of three novel MHC class I antigens derived from a C3H ultraviolet-induced fibrosarcoma.
Authors: R Linsk, J Vogel, H Stauss, J Forman, R S Goodenow
Journal: The Journal of Experimental Medicine (1986)

The UV-induced, C3H fibrosarcoma, 1591, expresses at least three unique MHC class I antigens not found on normal C3H tissue. Here we report the complete DNA sequence of the three novel class I genes encoding these molecules, and describe in detail the recognition of the individual products by tumor-reactive and allospecific CTL. Remarkably, although C3H does not appear to express H-2L locus information, this C3H tumor expresses two distinct antigens, termed A149 and A166, which are extremely homologous to each other and to the H-2Ld antigen from BALB/c. The gene encoding the third novel class I antigen from 1591, A216, is quite homologous to H-2Kk) throughout its 3' end. Since all three of these genes account for polymorphic restriction fragments not found in C3H, it is likely that they were derived by recombination from the endogenous class I genes of C3H. The DNA sequence homology of A149, A166, and H-2Ld is especially significant given the functional conservation observed between the products of these genes. Limited sequence substitutions appear to correlate with some of the discrete serological differences observed between these molecules. In addition, both A149 and A166 crossreact, but to differing extents, with H-2Ld at the level of T cell recognition. Our results are consistent with the view that CTL recognize complex conformational determinants on class I molecules, but extend previous observations by comparing a set of antigens with discrete and overlapping structural and functional differences.
Book Review The Starting Gate: Birth Weight and Life Chances By Dalton Conley, Kate W. Strully, and Neil G. Bennett. 258 pp., illustrated. Berkeley, University of California Press, 2003. $55 (cloth); $21.95 (paper). 0-520-23866-4 (cloth); 0-520-23955-5 (paper).
Authors: Ronald F. Lamont
Journal: New England Journal of Medicine (2004)
Alerting close relatives of patients with glaucoma.
Authors: J M MacKean, A R Elkington
Journal: BMJ (1984)

Importance du depistage precoce du glaucome chronique. Tout malade atteint de glaucome doit etre averti du caractere souvent familial de la maladie, et il faut conseiller a tous les parents proches de se faire examiner. Leurs chances de conserver une vision convenable est ainsi augmentee. Rapport d'un essai fait dans ce sens a partir de 214 malades atteints de glaucome
THE IMPORTANCE OF THE HOUSE-FLY AS A CARRIER OF E. HISTOLYTICA
Authors: P. A. Buxton
Journal: BMJ (1920)

LMKDZCAL J?OURPAZ experiences, and remembers crossing the Tower Bridge and finding it turned at right angles.After recalling this incident the patient was much better, but a few days later he went to the theatre t6' see Going Up (it is true that there is an aeroplane in Going Up), and he suddenly found that the theatre was the wrong way round.He went home, and in the middle of the night he woke up with tlle feeling of disorientation, got out of bed, and went towards what he thought was the window, and put hiis hand tliroughll the looliing-glass.Thus lhe was bv no means cured.I pointed out that tllere must be some memory in. the first six years of his life wlhich was tlle causs of the trouble.He tried to recall it, but did not make much.progress.I then puit him" thlrough his fourth birthday under hypnosis, and he riemembered a frightening dream in which hle had thought tliat there was an animal under the table.He lhad crawled downstairs and waked up half- way down.The next mrorning he had thought that the pier was the wrong way rouind, and had told his mother so.I interpreted his dream for him while' he was in tlle h;ypnotic trance.,He had seeni the Giaht Ape in a glass case at tlle Natural History Museum, South Kensington.'this had frightened him, and it wvas this creature whicl he had thouglht was under tlhe table in his dream.I took the precaution to get another doctor (Captain P. A. Galpin, R.A.M.C.) to come and see me lhypnotize this patient the next time.I then siiggested to -him -tlat he would go through his first experience of disorientation.When I put my hand on his forelhead lhe shouted out, "Hot coffee!"It appeared that, when a child of nearly three, lie had gone into the kitchen one morning, and had pulled thie coffee-pot, which was on the tabf6, toWvards him by pulling at tlle teblecloth.The coffee upset', and poured downn his: riglht arm.He felt it as a pain in his left side, o'ver-hig heart.Ile knew no moro:uatil lie woke up in bed, wliao lie saw his fatlher come into tlie room, and he felt tlle bd to bs the wrong way round.ThMb was his first eexp rieice of disorientation -tlie first lie could remember.it oceurred to me, as a possib!e 'exp1anation of tli .dissocjaion,'that tlhe scalding of hlis arm produced a fainting fit, inwhich he, fell to the left and everything twisted round lo the,glit' h'e fell througl-a riglit angle.Tliat was the be.giininga of hi* disorientation.e4i'', To make quite sure of this-Ihypnetizedkih.gain to
Endothelial Cell Migration and Vascular Endothelial Growth Factor Expression Are the Result of Loss of Breast Tissue Polarity
Authors: Amy Chen, Ileana Cuevas, Paraic A. Kenny, Hiroshi Miyake, Kimberley Mace, Cyrus Ghajar, Aaron Boudreau, Mina Bissell, Nancy Boudreau
Journal: Cancer Research (2009)

Abstract Recruiting a new blood supply is a rate-limiting step in tumor progression. In a three-dimensional model of breast carcinogenesis, disorganized, proliferative transformed breast epithelial cells express significantly higher expression of angiogenic genes compared with their polarized, growth-arrested nonmalignant counterparts. Elevated vascular endothelial growth factor (VEGF) secretion by malignant cells enhanced recruitment of endothelial cells (EC) in heterotypic cocultures. Significantly, phenotypic reversion of malignant cells via reexpression of HoxD10, which is lost in malignant progression, significantly attenuated VEGF expression in a hypoxia-inducible factor 1α–independent fashion and reduced EC migration. This was due primarily to restoring polarity: forced proliferation of polarized, nonmalignant cells did not induce VEGF expression and EC recruitment, whereas disrupting the architecture of growth-arrested, reverted cells did. These data show that disrupting cytostructure activates the angiogenic switch even in the absence of proliferation and/or hypoxia and restoring organization of malignant clusters reduces VEGF expression and EC activation to levels found in quiescent nonmalignant epithelium. These data confirm the importance of tissue architecture and polarity in malignant progression. [Cancer Res 2009;69(16):6721–9]
The utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS syndrome
Authors: Anita D'Souza, Suzanne R. Hayman, Francis Buadi, Michelle Mauermann, Martha Q. Lacy, Morie A. Gertz, Robert A. Kyle, Shaji Kumar, Philip R. Greipp, John A. Lust, Stephen J. Russell, Steven Zeldenrust, David Dingli, Thomas E. Witzig, S. Vincent Rajkumar, Angela Dispenzieri
Journal: Blood (2011)