tbuckley/cabot-search huggingface dataset:
Use of Blood Glucose Data by Families of Children and Adolescents with IDDM
Authors: Tim Wysocki, Brenda S Hough, Kory M Ward, Anthony A Allen, Neena Murgai
Journal: Diabetes Care (1992)

OBJECTIVE Prospective evaluation of the use of blood glucose test results for treatment actions by families of youth with IDDM. RESEARCH DESIGN AND METHODS Forty-seven patients with IDDM used reflectance meters with memory for SMBG for 28 days. Parents kept weekly diaries of six types of uses of SMBG data. We collected SMBG data from the reflectance meters, HbA1 and serum fructosamine assays, and measures of behavioral factors that could affect use of SMBG data. RESULTS Families recorded a mean of 4.85 data-based actions during the 28-day study, and 74% of the families reported at least one such action. Fifty percent of recorded actions consisted of management of hypoglycemia and, among the remainder, only 18% were anticipatory, proactive actions. Partial correlation analysis showed that families with more frequent use of SMBG data had less parent-child conflict about diabetes, more diabetes knowledge, and better overall treatment adherence. Use of SMBG data was unrelated to objective indices of the need for treatment adjustments or to diabetic control. CONCLUSIONS Most families made active use of their SMBG data, but few of these actions were proactive. Behavioral factors were stronger predictors of family use of SMBG data than were objective indices of the need for treatment adjustments. The results illustrate the need for further research on use of SMBG data and methods to enhance its impact on diabetic control.
Longitudinal Studies of Incidence and Progression of Diabetic Retinopathy Assessed by Retinal Photography in Pima Indians
Authors: Helen C. Looker, Jonathan Krakoff, William C. Knowler, Peter H. Bennett, Ronald Klein, Robert L. Hanson
Journal: Diabetes Care (2003)

OBJECTIVE—To examine incidence and progression of retinopathy using retinal photographs in Pima Indians and to compare the results with those obtained when retinopathy is assessed by direct ophthalmoscopy. RESEARCH DESIGN AND METHODS—We undertook an analysis of examinations conducted between 1 April 1982 and 31 December 1990 in residents of the Gila River Community in central Arizona. Data were taken from 411 people with diabetes who had at least two examinations during this period. Incidence and progression of retinopathy were evaluated by retinal photography and fundoscopy, and hazard rate ratios were calculated for various potential risk factors measured at baseline. RESULTS—Previously diagnosed retinopathy tended to progress, except in individuals with minimal nonproliferative retinopathy, among whom follow-up examinations were more likely to show no retinopathy. Diabetes duration (hazard rate ratio [HRR], 1.06 per year difference [P = 0.007]), hyperglycemia (HbA1 HRR, 1.27 per 1% difference [P &amp;lt; 0.0001]), the type of treatment for diabetes (insulin use HRR, 3.06 [P = 0.0007], and oral hypoglycemic use HRR, 2.40 [P = 0.0034], compared with individuals on no pharmacotherapy), and macroalbuminuria (HRR, 2.86, compared with individuals without macroalbuminuria [P = 0.0486]) were associated with the development of retinopathy. Although fundoscopy detected fewer cases of retinopathy, HRRs for most risk factors were similar when retinopathy was assessed by fundoscopy rather than retinal photography. CONCLUSIONS—Although retinopathy tends to worsen over time, some eyes show improvement, especially in patients with minimal nonproliferative retinopathy. As in other populations, glycemic control is the major modifiable risk factor for the development and progression of retinopathy.
C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S–independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies
Authors: Alfonso Buil, David-Alexandre Trégouët, Juan Carlos Souto, Noémie Saut, Marine Germain, Maxime Rotival, Laurence Tiret, Françcois Cambien, Mark Lathrop, Tanja Zeller, Marie-Christine Alessi, Santiago Rodriguez de Cordoba, Thomas Münzel, Philipp Wild, Jordi Fontcuberta, France Gagnon, Joseph Emmerich, Laura Almasy, Stefan Blankenberg, José-Manuel Soria, Pierre-Emmanuel Morange
Journal: Blood (2010)
Endpoints in short-term tests: significance for carcinogenic potential
Authors: VIRGINIA C. DUNKEL
Journal: British Journal of Dermatology (1986)

Journal Article Endpoints in short‐term tests: significance for carcinogenic potential Get access VIRGINIA C. DUNKEL VIRGINIA C. DUNKEL Genetic Toxicology Branch, Center for Food Safety and Applied Nutrition, Food and Drug, Administration, Washington, DC 20204, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s31, 1 August 1986, Pages 117–125, https://doi.org/10.1111/j.1365-2133.1986.tb02120.x Published: 01 August 1986
ACOs—Promise, Not Panacea
Authors: Donald M. Berwick
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interaction of human liver connective tissue cells, skin fibroblasts and smooth muscle cells with collagen gels
Authors: Alvaro N. A. Monteiro, Radovan Borojevic
Journal: Hepatology (1987)

Interactions of liver connective tissue cells, skin fibroblasts and smooth muscle cells with collagen gels in vitro were studied and compared. Liver connective tissue cells showed the lowest rate of migration into the gel and the highest speed of gel contraction, reflecting their high adhesiveness to the substrate as compared to the other cell lines studied. The analysis of their ultrastructural morphology showed that liver connective tissue cells and smooth muscle cells developed cytoskeletal and cytoplasmic organelle polarities, in response to the contact with gel surface. This polarity was lost when cells were embedded in the gel. Skin fibroblasts did not show this characteristic, neither on top nor in the gel. Although liver connective tissue cells have been recognized as analogous to smooth muscle cells, they represent a defined cell population, present in fibrotic livers, with specific behavior and with particular relationship to the extracellular matrix.
The novel AML stem cell–associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells
Authors: Anna van Rhenen, Guus A. M. S. van Dongen, Angèle Kelder, Elwin J. Rombouts, Nicole Feller, Bijan Moshaver, Marijke Stigter-van Walsum, Sonja Zweegman, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis
Journal: Blood (2007)
Electrohydraulic Impulse Lithotripsy of Bladder Stones with URAT-I
Authors: M. Trapeznikova, G. Borodulin
Journal: Endoscopy (1977)

The electrohydraulic method of crushing bladder stones due to many aforesaid advantages can fully replace mechanical lithotripsy as being both more effective and having little danger of traumas. In rare cases when the stone cannot be crushed with Urat-I its removal should be performed by way of cystomy.
Macrovascular disease in diabetics in Central Africa
Authors: M Rolfe
Journal: BMJ (1988)

Six hundred African diabetics were examined for evidence of large vessel disease using a standardised technique based on the World Health Organisation Multinational Study, in which no country from Africa was represented. Twelve patients had electrocardiograms coded coronary probable using Minnesota coding. Seven patients had had strokes and 10 peripheral vascular disease. Despite the high prevalence of hypertension large vessel disease was uncommon, being comparable with Japan and Hong Kong, who had the lowest prevalence in the WHO study. Overall, only 49 patients had evidence of macrovascular disease.
An Integrated Health-Science Core Library for Physicians, Nurses and Allied Health Practitioners in Community Hospitals
Authors: Norman S. Stearns, Wendy W. Ratcliff
Journal: New England Journal of Medicine (1970)

Abstract The Core Medical Library has been revised, updated and expanded in the hope of providing a single library facility for the entire health-care team. Items were included in the list on the basis of recommendations submitted by specialists in the pertinent fields. The expanded core collection costs about $4,000. Space requirements are about 40 linear feet for books, 90 feet for journals and 15 feet for reference tools.
Glucagon and the a Cell
Authors: Roger H. Unger, Lelio Orci
Journal: New England Journal of Medicine (1981)

IN this review we examine the role of glucagon, a polypeptide produced by the islets of Langerhans and a biologic antagonist of insulin. The effects of glucagon balance those of insulin so that fluctuations in blood sugar levels in response to sudden changes in fluxes of fuels are prevented.By definition, relative hyperglucagonemia is present in all forms of diabetes in which glucose production exceeds glucose disposal and thus causes "endogenous hyperglycemia"; in the absence of glucagon-like biologic activity the massive hepatic overproduction of glucose and ketones observed in uncontrolled diabetes does not occur, even in the total absence of . . .
Plectin deficiency results in muscular dystrophy with epidermolysis bullosa
Authors: F.J.D. Smith, R.A.J. Eady, I.M. Leigh, J.R. McMillan, E.L. Rugg, D.P. Kelsell, S.P. Bryant, N.K. Spurr, J.F. Geddes, G. Kirtschig, G. Milana, A.G. de Bono, K. Owaribe, G. Wiche, L. Pulkkinen, J. Uitto, W.H.I. McLean, E.B. Lane
Journal: Nature Genetics (1996)
Simple computerised disease register.
Authors: D Meldrum
Journal: BMJ (1981)

Since the pioneering work by Eimerl' and others general prac? titioners have been able to monitor their work load and recall groups of patients according to either age or disease. Age/sex registers have been widely used, but disease registers, particularly ones that register all diseases and all patients seen, have presented formidable problems of collecting and analysing data. The introduction of relatively cheap computers, however, has made it practical to have a simple system for recording and analysing information about diseases.* * General practitioners in routine teaching practices have been able to examine the overall work load of trainees using a manual system. But because of the difficulties of examining and sifting data, it has not been practical to monitor continuously the distribution of patients seen by trainees by age and sex and by disease. Although small computers can be bought for under ?1000 they do not have adequate memories to store all the information required for an age/sex register and a disease index.2 To get around this problem I developed a combination of a manual age/sex index and a computerised disease register.
THE EFFECT OF VARIOUS MEDICATIONS ON PATIENTS MANIFESTING AN EPILEPTIFORM SYNDROME
Authors: LORNE D. PROCTOR
Journal: American Journal of Psychiatry (1947)

One hundred and thirty cases presenting a syndrome including cranialgia, emotional instability, vasomotor instability, impaired consciousness, loss of consciousness, personality disorders and epilepsy, have been found to have a common EEG component, namely half and double alpha variants. Ninety-five percent of the cases had impaired states of consciousness and a significant proportion grand mal epileptic features. The series has shown a selective response to trials on several medications, improvement occurring in 90% of patients placed on dilantin sodium. Phenobarbital or sodium amytal were of little benefit. It is suggested this syndrome is more inclusive than those conditions variously described as psychomotor attacks, psychic variants or equivalents, or psychical seizures, and warrants the term epileptiform syndrome. The syndrome enlarges our conception of the limits of epilepsy.
Prospective Exploratory Analysis of Cardiac Biomarkers and Electrocardiogram Abnormalities in Patients Receiving Thoracic Radiation Therapy with High-Dose Heart Exposure
Authors: Daniel R. Gomez, Syed Wamique Yusuf, Mark F. Munsell, James W. Welsh, Zhongxing Liao, Steven H. Lin, Hubert Y. Pan, Joe Y. Chang, Ritsuko Komaki, James D. Cox, Mary Frances McAleer, David R. Grosshans
Journal: Journal of Thoracic Oncology (2014)
Abstract P2-16-03: Sorafenib in Combination with Paclitaxel as a First-Line Therapy in Patients with Locally Recurrent or Metastatic Breast Cancer: Overall Survival Results from a Double-Blind, Randomized, Placebo-Controlled, Phase 2b Trial
Authors: S Bondarde, V Kaklamani, T Prasad Sahoo, D Lokanatha, V Raina, M Jain, L Schwartzberg, WJ. Gradishar
Journal: Cancer Research (2010)

Abstract Background: Sorafenib (SOR) is an oral multikinase inhibitor that targets tumor growth and angiogenesis. We previously reported progression-free survival (PFS) data from the primary analysis of NU07B1 (SABCS 2009 abstr 44), a phase 2b trial assessing the combination of SOR + paclitaxel (PAC) in patients with advanced breast cancer (BC). Here we report overall survival (OS) data, a secondary endpoint. Methods: NU07B1 is a multinational (India, United States, Brazil) phase 2b study in HER2-negative patients with locally advanced or metastatic BC. Eligibility criteria allowed prior endocrine or radiation therapy and adjuvant use of taxanes and other chemotherapy. Patients with prior chemotherapy for advanced BC were not eligible. Patients were randomized (1:1) to receive PAC (90 mg/m2 IV weekly, 3 wk on/1 wk off) with placebo (PL) or SOR (400 mg po, twice daily). The primary endpoint was PFS. The sample size was estimated at 220 patients based on patient accrual projections and estimated rate of PFS events. OS analysis was planned after 120 events. Results: A total of 237 patients were enrolled from June 2007 to January 2009. Study arms were balanced for age (mean, 51.9 y), ECOG performance 0 (45%) and 1 (53%), stage IV disease (85%), visceral metastatic disease (75%), and previous non-metastatic chemo (58%). In the primary analysis, PFS trended in favor of SOR+PAC vs PL+PAC with median PFS of 6.9 vs 5.6 mo (HR 0.79, 95% CI 0.56-1.11; 1-sided log rank P=0.09); Grade 3/4 toxicities included hand-foot skin reaction (30% vs 3%), neutropenia (13% vs 7%), and anemia (11% vs 6%); treatment-related deaths occurred in 2 patients (malaria and liver dysfunction), both in the SOR+PAC arm. Overall survival data are expected by 4th quarter of 2010 and will be presented, as well as updated safety data. Conclusions: Further study with SOR+PAC appears warranted but may require adjustments to the dosing algorithm and patient selection criteria to provide a more defi-nitive assessment of benefit-to-risk profile. OS data will help to determine whether this combination should be pursued further. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-16-03.
Oration on Harvey's 'Exercises on Generation.'
Authors: A. Farre
Journal: BMJ (1872)

PRESIDENT AND FELLOWS,-This day serves to recall an event which, two hundred a1id fifteen years ago, must have been the occasion of much sorrow to the Fellows of outr College then assembled.On the 26th of June, in I657, Harvey was carried to his grave, a long train of his friends and colleagues following far beyond the city walls.But of Harvey dead it is not my purpose further to speak.Rather let us regard him as living still among us, in the records of his works, in the memory of the benefits which he conferred upon this College, and in the bright example of his character and mind.On any occasion on which the countrymen of Harvey meet, with the object of carrying out his expressed wish, that annually an oration should be delivered, no difficulty need be felt on the part of him who is appointed to that duty in finding a subject suitable to the purpose.And although, in ac- cordance with custom, such address need have no reference to the founder, further than with a view of recalling his desire to mind, that the orator should " exhort the menibers of the College to study and search out the secrets of Nature by way of experiment", yet, should the speaker find in Harvey's works matter which may have been se- lected by himself for particular study and investigation, he would naturally take that subject as furnishing him with the best material.It is on this ground, therefore, that I have taken the subject of GCeneration, as exemplified in the celebrated Exercises of Harvey, which, although constituting by no means the more important of his two great works,
REPORT ON THE RESULTS OF EXAMINATION OF NINE CASES AFTER THE ORAL INGESTION OF 1,000 GRAMS OF GLUCOSE
Authors: W. J. May
Journal: BMJ (1928)

IT lhas been stated by different authorities that it is impossible to make a normal person pass sugar in the urine after the oral ingestion of glucose.The leak poilt of the kidney for glucose is now generally re'ognlize'ld as being between 0.16 and 0.18 per cent.MacLeanil states that the hyperglycaemiiia resulting from the ingestion of carbohydrates appears, in tlle niormiiial indiv-idulal, to be limited to about this level, the threshold level fol glutcose, and cannot easily, if at all, be forced above it.He also goes on to state that in this fact lies the explanation of the difficulty in provoking glycosuria in thle normal ind(livilual by giving glucose, a difficuiltv referred to in several recent publications.Later on in the same book2 lhe qtuotes Taylor, who, as the result of experimnenital work,3 stated that " in the majority of healthy males tlhere is no limiiit of assimilation of glucose; glycosuria (loes not occur1 followling the largest possible inigestioni of pture glucose."These observers in five instanices gave doses of 500 gramiis of glucose, with the production of glycosuria in onie case onl\.Shapland,4 commenting on this subject, states that- A striking plhenomenon in the curve of the healthy subject is
Abstract B71: Inhibiting the CSF-1 receptor on tumor-infiltrating monocytes may enhance the efficacy of radiotherapy for glioblastoma multiforme
Authors: Jason H. Stafford, Sophia Chernikova, Brian L. West, J. Martin Brown
Journal: Cancer Research (2015)

Abstract Glioblastoma (GBM) is the most common brain tumor and is one of the most deadly forms of cancer with median survival only 15 months after diagnosis. Ionizing radiation (IR) is the most effective treatment for GBM, but the prognosis remains poor because the tumors invariably recur. We have previously shown that bone marrow-derived monocytes promote GBM recurrence after radiotherapy by homing to the irradiation site and stimulating the growth of new tumor blood vessels in a process referred to as vasculogenesis. We found that this infiltration of monocytes can be prevented and tumor recurrences delayed by inhibition of the SDF-1/CXCR4 chemokine axis. Here we present data that suggest Colony Stimulating Factor-1 (CSF-1) may also play an important role in this phenomenon. CSF-1 is a potent chemokine secreted by several different types of solid tumors and is also the main growth factor regulating the differentiation of monocytes into macrophages. RT-PCR analysis of U251 GBM tumors growing in mice revealed a more than 12.5-fold increase in expression of CSF-1 after treatment with a single dose of 12 Gy IR. Increased CSF-1 expression in these tumors correlated with increased recruitment of CD11b+ monocytes. Immunohistochemistry (IHC) and fluorescence activated cell sorting (FACS) showed that the number of CD11b+ monocytes in GBM tumors had approximately doubled within 2 weeks of IR treatment. F4/80 staining indicated that the majority of the CD11b+ cells were mature macrophages. Treatment with 40 mg/kg/day PLX3397, which inhibits the receptor for CSF-1 (CSF-1R), effectively blocked the recruitment of monocytes/macrophages to the irradiated tumors and inhibited tumor blood vessel formation. Moreover, bioluminescence imaging (BLI) of intracranial U251-luciferase tumors growing in mice showed that combined treatment with IR and PLX3397 was more effective at inhibiting tumor growth than IR alone. Eighty percent of mice treated with IR and PLX3397 were alive at 50 days post-irradiation whereas there were no survivors among groups receiving monotherapy. These results suggest inhibition of CSF-1R may prevent post-irradiation recurrence of GBM by blocking the recruitment of tumor-infiltrating monocytes/macrophages. Citation Format: Jason H. Stafford, Sophia Chernikova, Brian L. West, J. Martin Brown. Inhibiting the CSF-1 receptor on tumor-infiltrating monocytes may enhance the efficacy of radiotherapy for glioblastoma multiforme. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr B71. doi:10.1158/1538-7445.CHTME14-B71
Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-κB and MAPK activation to selectively control cytokine production
Authors: Olaf Gross, Christina Grupp, Christian Steinberg, Stephanie Zimmermann, Dominikus Strasser, Nicole Hannesschläger, Wolfgang Reindl, Helena Jonsson, Hairong Huo, Dan R. Littman, Christian Peschel, Wayne M. Yokoyama, Anne Krug, Jürgen Ruland
Journal: Blood (2008)
TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting
Authors: Andreas Herrmann, Gregory Cherryholmes, Anne Schroeder, Jillian Phallen, Darya Alizadeh, Hong Xin, Tianyi Wang, Heehyoung Lee, Christoph Lahtz, Piotr Swiderski, Brian Armstrong, Claudia Kowolik, Gary L. Gallia, Michael Lim, Christine Brown, Behnam Badie, Stephen Forman, Marcin Kortylewski, Richard Jove, Hua Yu
Journal: Cancer Research (2014)

Understanding supports for cancer stem-like cells in malignant glioma may suggest therapeutic strategies for their elimination. Here, we show that the Toll-like receptor TLR9 is elevated in glioma stem-like cells (GSC) in which it contributes to glioma growth. TLR9 overexpression is regulated by STAT3, which is required for GSC maintenance. Stimulation of TLR9 with a CpG ligand (CpG ODN) promoted GSC growth, whereas silencing TLR9 expression abrogated GSC development. CpG-ODN treatment induced Frizzled4-dependent activation of JAK2, thereby activating STAT3. Targeted delivery of siRNA into GSC was achieved via TLR9 using CpG-siRNA conjugates. Through local or systemic treatment, administration of CpG-Stat3 siRNA to silence STAT3 in vivo reduced GSC along with glioma growth. Our findings identify TLR9 as a functional marker for GSC and a target for the delivery of efficacious therapeutics for glioma treatment. Cancer Res; 74(18); 5218-28. ©2014 AACR.