tbuckley/cabot-search huggingface dataset:
Classifying mental and neurological conditions together: authors' reply to letters
Authors: P. D. White, H. Rickards, A. Z. J. Zeman
Journal: BMJ (2012)

We argued that psychiatric and neurological conditions should be classified together because they are both essentially disorders of the nervous system.1 However, we also argued that psychological and social considerations are vitally important throughout medicine. We therefore agree with Holmes that “many ‘brain diseases’ result from . . . environmental and developmental processes.”2 But we disagree that …
Doctors' knowledge of radiation exposure: questionnaire study
Authors: S Shiralkar
Journal: BMJ (2003)

Despite the small but definite risk to patients' health, investigations involving radiation are an accepted and fundamental part of medical practice. In the United Kingdom an estimated 100-250 deaths occur each year from cancers directly related to medical exposure to radiation.1 In March 2000, the UK secretary of state issued new regulations that emphasised the importance and dangers of radiation.2 3

We investigated the level of knowledge doctors have concerning radiation doses received by patients when they undergo commonly requested radiological investigations.

We compiled a questionnaire listing the most commonly requested radiological investigations. Participants were asked to identify the average dose of radiation received when a person underwent a standard chest x ray. This was then used to represent a single dose of radiation, and doctors were asked to estimate …
Irreversible Silicone Oil Adhesion to Silicone Intraocular Lenses
Authors: David J. Apple, Jay L. Federman, Thaddeus J. Krolicki, John C.R. Sims, David G. Kent, Harry A. Hamburger, William E. Smiddy, Morton S. Cox, Tarek S. Hassan, Stephanie M. Compton, Stephanie G. Thomas
Journal: Ophthalmology (1996)
Gastric Hypochlorhydria and Achlorhydria in Older Adults
Authors: Robert M. Russell
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The article on gastric acidity in older adults by Dr Hurwitz and colleagues<sup>1</sup>is of great interest. It is well known that hypochlorhydria does not often result in the colonization of the upper gastrointestinal tract with bacterial pathogens.<sup>2</sup>However, hypochlorhydria due to atrophic gastritis can result in malabsorption of food-bound vitamin B<sub>12</sub>, and this continues to be a public health concern.<sup>3,4</sup> We studied the prevalence of atrophic gastritis in a white elderly population approximately 12 years ago and found the overall prevalence of atrophic gastritis in those older than 60 years to be approximately 30%.<sup>5</sup>This contrasts with the 9% prevalence of atrophic gastritis in the Midwest population in the present study using the same criterion for diagnosis.<sup>1</sup>Unlike the study by Hurwitz et al, our study found the prevalence of atrophic gastritis to increase with advancing age. In Boston, Mass
Duncan Stuart Gibbs
Authors: James Allenby, Michael Inman
Journal: BMJ (2008)

Duncan Stuart Gibbs was born on 12 March 1939 in New Zealand, where his father was a general surgeon in Wellington. After schooling in Nelson, he went to Otago University, Dunedin, where he qualified in 1965. After a year of house jobs, he set off to explore the world, working in Vancouver for a year before travelling through North and South …
NF-KB INHIBITION PROTECTS AGAINST MYOCARDIAL ISCHEMIA/REPERFUSION INJURY VIA ACTIVATION OF ANTIAPOPTOTIC SIGNALING
Authors: Kashyap Choksi, Harold Elias, Guangming Cheng, Arash Davani, Anweshan Samanta, Lei Chen, Lin Zhao, Amy Cantilena, Robert Vincent, Magdy Girgis, Yanjuan Yang, Jeryl Hauptman, Buddhadeb Dawn
Journal: Journal of the American College of Cardiology (2015)
Vitamin D Therapy and Cardiac Function in Chronic Kidney Disease—Reply
Authors: Stefan D. Anker, Stephan von Haehling
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bioterrorism and compulsory vaccination: United States continues vaccinating to keep troops healthy
Authors: John D Grabenstein, William Winkenwerder
Journal: BMJ (2004)

EDITOR—Jefferson questions military use of anthrax and smallpox vaccines licensed as safe and effective by the US Food and Drug Administration (FDA).1 The Department of Defense is concerned about the safety of US service members, so we vaccinate them to keep them healthy. Vaccination provides the only round the clock protection against the malicious use of microbes as weapons.

Our vaccination programmes are based …
A trial of deglycyrrhizinated liquorice in the treatment of duodenal ulcer
Authors: H. Feldman, T. Gilat
Journal: Gut (1971)

A double-blind trial of deglycyrrhizinated liquorice was performed in 47 patients with active duodenal ulcer. Twenty-four patients received a placebo and 23 the trial medication (Caved-S) for one month. Both groups were clinically similar. No advantage of deglycyrrhizinated liquorice over placebo was found.
Ketoconazole for Male Metastatic Breast Cancer
Authors: LORNE D. FELDMAN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 January 1986Ketoconazole for Male Metastatic Breast CancerLORNE D. FELDMAN, M.D.LORNE D. FELDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-1-123_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Breast cancer accounts for more than 25% of malignancies in women but less than 0. 2% of malignancies in men (1). Compared to women, men are generally older and have a more advanced stage of breast cancer at diagnosis. The presentation in them frequently includes a periareolar breast mass, ulcerative abnormalities of the nipple, invasion of the pectoralis muscle, and involvement of the axillary lymph node. Radical mastectomy is the usual approach to control the primary neoplasm. Distant metastatic sites are similar to those seen in women. The frequency of estrogen- and progesterone-receptor positivity is higher in...References1. DEVITAHELLMANROSENBERG VSS. Cancer Principles & Practice of Oncology. 2nd ed. Philadelphia: J. B. Lippincott Company; 1985:1167-8. Google Scholar2. KANTARJIANYAPHORTOBAGYIBUZDARBLUMENSCHEIN HHGAG. Hormonal therapy for metastatic breast cancer. Arch Intern Med. 1983;143:237-40. CrossrefMedlineGoogle Scholar3. LOOSEKANHIRST DPM. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P-450 enzymes. J Clin Invest. 1983;71:1495-9. CrossrefMedlineGoogle Scholar4. TRACHTENBERGPONT JA. Ketoconazole therapy for advanced prostate cancer. Lancet. 1984;2:433-5. CrossrefMedlineGoogle Scholar5. LABRIEDUPONTBELANGER FAA. New approach in the treatment of prostate cancer: complete instead of only partial withdrawal of androgens. Prostate. 1983;4:579-94. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LORNE D. FELDMAN, M.D.Affiliations: University of Toronto Toronto Western Hospital Toronto, Ontario M5T 2R2 Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmacologic treatment of male breast cancerMale breast cancer: a review of clinical managementPharmacotherapy for male breast cancerMale breast cancer: a review of the literatureCarcinoma of the male breast: Update 1994Antitumor effects of ketoconazole and trifluoperazine in murine T-cell lymphomasInhibition of human adrenal androgen secretion by ketoconazoleInhibition of testicular 17α-hydroxylase and 17,20-lyase but not 3β-hydroxysteroid dehydrogenase-isomerase or 17β-hydroxysteroid oxidoreductase by ketoconazole and other imidazole drugs 1 January 1986Volume 104, Issue 1Page: 123-124KeywordsBreast cancerEstrogensLymph nodesMuscles ePublished: 1 December 2008 Issue Published: 1 January 1986 PDF downloadLoading ...
Cytokine-mediated effects of peripheral blood mononuclear cells from patients with atopic eczema on keratinocytes (HaCaT) in a new coculture system
Authors: K. NELBER, K. STEINRÜCKE, L. KOWALZICK, I. KÖHLER, J. RING
Journal: British Journal of Dermatology (2006)

Interactions between keratinocytes and mononuclear cells via cytokines and adhesion molecules are thought to play a crucial part in inflammatory skin diseases. The cytokine-mediated effects of peripheral blood mononuclear cells (PBMC) from patients with atopic eczema (AE) and healthy individuals on keratinocytes (HaCaT) were investigated in vitro. A new coculture model (Transwell system) which consists of a lower and an upper compartment, which are separated by a polycarbonate-treated membrane, was established. 3[H]thymidine incorporation of keratinocytes and lymphocytes, as well as IL-6, IL-8 and IFN-gamma synthesis, were measured. Keratinocyte proliferation was significantly enhanced in the presence of PBMC from patients with AE. In contrast, PBMC from normal donors did not enhance HaCaT cell proliferation when they were cocultured. Lymphocytes from patients with AE showed a significantly enhanced proliferation after coculture with keratinocytes. However, PBMC from normal donors did not proliferate in the presence of HaCaT cells. Keratinocyte supernatants incubated with PBMC from either atopic or normal volunteers induced a suppression of lymphocyte 3[H]thymidine incorporation. In supernatants from cocultures of PBMC from patients with AE and keratinocytes, significantly enhanced amounts of IL-6 and IL-8, compared with normal donor's lymphocytes and HaCaT cells, were measured. No differences in IFN gamma production were observed. When PBMC were cultured without HaCaT cells, supernatants contained equal levels of IL-6, IL-8 and IFN-gamma in normal donors and in patients with AE. Interestingly, HaCaT cells spontaneously secrete measurable amounts of IL-6, IL-8 and IFN-gamma. Blocking experiments with neutralizing antibodies against these interleukins showed a complete inhibition of keratinocyte proliferation when PBMC from normal donors were used whereas the proliferative potency of PBMC supernatants from patients with AE on keratinocytes remained. Our data indicate that (i) PBMC from patients with AE stimulate keratinocyte proliferation via soluble factor(s) that are different from IL-6, IL-8 and IFN-gamma; (ii) probably, HaCaT cells spontaneously produce lymphocyte/monocyte inhibitory soluble factors and IL-6, IL-8 as well as IFN-gamma; and (iii) secretion and/or activity of keratinocyte-derived inhibitory mediators is regulated via cytokines of PBMC infiltrating inflammatory skin.
Unusual Soft Tissue Infiltrates With 18F-FDG Uptake in a Patient With Hairy Cell Leukemia
Authors: Glenna Gibson, Jerome Lai, Paul Thomas
Journal: Clinical Nuclear Medicine (2015)

Hairy cell leukemia (HCL) is an uncommon B-cell lymphoproliferative disorder, representing approximately 2% of leukemias. Diagnostic features include pancytopenia, splenomegaly, bone marrow reticulin fibrosis, and circulating hairy cells. Less commonly, there may be involvement of the liver and lymph nodes. We present a case of a 53-year-old man with HCL who was found to have soft tissue masses within the mediastinum and neck during pretreatment workup. An F-FDG PET/CT scan was requested to assess these lesions before treatment. These extensive infiltrates were FDG avid, and core biopsy of the mediastinal tissue was undertaken. Results were consistent with HCL.
Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1: report of a novel and a recently reported mutation in two unrelated Chinese families
Authors: Z-L. Bai, Y-G. Feng, S-S. Tan, X-Y. Wang, S-X. Xiao, H. Wang, H-Q. Jia, J-W. Wu, D-L. He, R-H. Kang
Journal: British Journal of Dermatology (2008)

Journal Article Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1: report of a novel and a recently reported mutation in two unrelated Chinese families Get access Z‐L. Bai, Z‐L. Bai Department of Dermatology, the Second Hospital, Xi’an Jiaotong University, 157 Xiwu Road, Xi’an, Shaanxi 710004, China Search for other works by this author on: Oxford Academic Google Scholar Y‐G. Feng, Y‐G. Feng Department of Dermatology, the Second Hospital, Xi’an Jiaotong University, 157 Xiwu Road, Xi’an, Shaanxi 710004, China Correspondence: Yi‐Guo Feng. E‐mail: fengyiguo70@163.com Search for other works by this author on: Oxford Academic Google Scholar S‐S. Tan, S‐S. Tan Department of Dermatology, the Second Hospital, Xi’an Jiaotong University, 157 Xiwu Road, Xi’an, Shaanxi 710004, China Search for other works by this author on: Oxford Academic Google Scholar X‐Y. Wang, X‐Y. Wang Institute of Urology, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi’an Jiaotong University, Xi'an, Shaanxi, China Search for other works by this author on: Oxford Academic Google Scholar S‐X. Xiao, S‐X. Xiao Department of Dermatology, the Second Hospital, Xi’an Jiaotong University, 157 Xiwu Road, Xi’an, Shaanxi 710004, China Search for other works by this author on: Oxford Academic Google Scholar H. Wang, H. Wang Department of Dermatology, the Second Hospital, Xi’an Jiaotong University, 157 Xiwu Road, Xi’an, Shaanxi 710004, China Search for other works by this author on: Oxford Academic Google Scholar H‐Q. Jia, H‐Q. Jia Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China Search for other works by this author on: Oxford Academic Google Scholar J‐W. Wu, J‐W. Wu Department of Dermatology, the Second Hospital, Xi’an Jiaotong University, 157 Xiwu Road, Xi’an, Shaanxi 710004, China Search for other works by this author on: Oxford Academic Google Scholar D‐L. He, D‐L. He Institute of Urology, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi’an Jiaotong University, Xi'an, Shaanxi, China Search for other works by this author on: Oxford Academic Google Scholar R‐H. Kang R‐H. Kang Department of Dermatology, the Fourth Clinical Medical College of Hebei Medical University, Shijiazhuang, China Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 1, 1 July 2008, Pages 238–240, https://doi.org/10.1111/j.1365-2133.2008.08603.x Published: 01 July 2008
Abstract 17863: Prospective Validation of a Model to Predict In-Hospital Mortality After Pediatric Heart Transplantation
Authors: Christopher Almond, Kimberlee Gauvreau, Charles Canter, Gary Piercey, Tp Singh
Journal: Circulation (2010)

Background:  We previously developed and cross-validated a risk-prediction model to predict in-hospital mortality for children undergoing heart transplant (HT). This model has not been independently validated in a prospective cohort of patients. We sought to prospectively validate this risk-prediction model in an independent cohort of children transplanted during the year since the model was developed.   Methods:  We applied a previously developed risk prediction model to all children    Results:  Of 338 children in the prospective validation cohort, the median age was 3.7 yrs (IQR 0.7 to 12.7), 45% had CHD, 4% were on ECMO, 19% were on VAD support, and 4% had severe renal dysfunction. Overall, 6.2% died prior to hospital discharge with the risk of in-hospital mortality ranging from  60% for patients with CHD supported on ECMO with severe end-organ dysfunction. The C-statistic (0.835) and the Hosmer-Lemeshow goodness-of-fit (P=0.54) suggested excellent prediction of in-hospital mortality.   Conclusions:  When applied to an independent cohort of patients, this risk prediction model using 4 baseline clinical factors available at transplant had excellent prediction characteristics for in-hospital mortality after HT. This model may be useful to inform decision-making around patient eligibility for transplant, timing of mechanical support, and potentially organ allocation policy.
305. Targeting the Gene and the Derived Gene- Product into Tumors
Authors: Shulin Li, Ryan Craig, Marina Torrero
Journal: Molecular Therapy (2006)

Great effort has been made in developing tumor-targeted gene delivery, but no attention has been given to targeting the therapeutic gene products that are transcribed and translated from genes transfected in normal tissues into tumors. Targeting gene product in tumors is very important for systemic gene delivery because only a portion of genes are successfully delivered into tumors by using the most successful systemic tumor-targeted gene delivery technology. Targeting gene product in tumors is also important for intratumoral gene delivery because the most commonly used therapeutic genes like TRAIL yield soluble proteins that are secreted into the blood circulation and are harmful to normal cells. Moreover, some gene products such as IL-12 are more effective when co-localized with tumors, compared to systemic localization (Li, S., JNCI, 2002; Li, S., Mol Therapy, 2005). To target not only the gene but also the gene product generated from the injected in tumors, a novel strategy is reported here. In brief, a tumor vessel-targeted reporter gene encoding SEAP and a tumor vessel-targeted peptide CDGRC was generated in our laboratory. The gene expression analysis using this tumor vessel-targeted reporter gene clearly demonstrates that inclusion of CDGRC increases gene product accumulation in tumors following systemic administration of the fusion gene via electroporation. Likewise, injection of tumor vessel-targeted IFNalpha gene, encoding tumor vessel-targeted mini-peptide(s) CDGRC and IFNalpha into SCCVII tumors in a syngeneic immunocompetent model, significantly increases the infiltration of CD8 T cells, decreasing the tumor vessel density, and increasing the survival of tumor-bearing mice, compared to administration of the wild-type IFNalpha gene. This therapeutic strategy has a great potential for reducing the systemic toxicity and increasing the therapeutic efficacy. Members from the University of South Florida.
Results of balloon valvuloplasty in typical and dysplastic pulmonary valve stenosis: Doppler echocardiographic follow-up
Authors: Pablo M. Marantz, James C. Huhta, Charles E. Mullins, Daniel J. Murphy, Michael R. Nihill, Achi Ludomirsky, Grace Y. Yoon
Journal: Journal of the American College of Cardiology (1988)
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery
Authors: Masahiko Hoshijima, Yasuhiro Ikeda, Yoshitaka Iwanaga, Susumu Minamisawa, Moto-o Date, Yusu Gu, Mitsuo Iwatate, Manxiang Li, Lili Wang, James M. Wilson, Yibin Wang, John Ross, Kenneth R. Chien
Journal: Nature Medicine (2002)
DO ELDERLY PATIENTS WITH HEART FAILURE DUE TO LEFT VENTRICULAR SYSTOLIC DYSFUNCTION BENEFIT FROM NT-PROBNP-GUIDED HEART FAILURE MANAGEMENT? RESULTS FROM THE PROBNP OUTPATIENT TAILORED CHRONIC HEART FAILURE THERAPY (PROTECT) STUDY
Authors: Han-Na Kim, Asim A. Mohammed, Anju Bhardwaj, Shafiq Rehman, Shawn A. Gregory, Justine A. Barajas, Linda J. Barajas, Rory B. Weiner, Aaron L. Baggish, Stephanie A. Moore, Marc J. Semigran, James L. Januzzi
Journal: Journal of the American College of Cardiology (2011)
A study of lymph nodes draining colorectal cancer using a two-stage inhibition of leucocyte migration technique.
Authors: P J Guillou, T G Brennan, G R Giles
Journal: Gut (1975)

A two-stage technique for leucocyte migration inhibition has been developed which demonstrates the sensitization of lymph node lymphocytes to colorectal tumour extract. The studies have confirmed that some lymph nodes draining colorectal carcinomata contain sensitized lymphocytes. However, the degree of lymphocyte sensitization to tumour extract does not seem greater than that seen in lymph nodes of the small bowel mesentery or of the peripheral blood.
IL4 Receptor ILR4α Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
Authors: Katherine T. Venmar, Kathy J. Carter, Daniel G. Hwang, E. Ashley Dozier, Barbara Fingleton
Journal: Cancer Research (2014)

Abstract IL4, a cytokine produced mainly by immune cells, may promote the growth of epithelial tumors by mediating increased proliferation and survival. Here, we show that the type II IL4 receptor (IL4R) is expressed and activated in human breast cancer and mouse models of breast cancer. In metastatic mouse breast cancer cells, RNAi-mediated silencing of IL4Rα, a component of the IL4R, was sufficient to attenuate growth at metastatic sites. Similar results were obtained with control tumor cells in IL4-deficient mice. Decreased metastatic capacity of IL4Rα “knockdown” cells was attributed, in part, to reductions in proliferation and survival of breast cancer cells. In addition, we observed an overall increase in immune infiltrates within IL4Rα knockdown tumors, indicating that enhanced clearance of knockdown tumor cells could also contribute to the reduction in knockdown tumor size. Pharmacologic investigations suggested that IL4-induced cancer cell colonization was mediated, in part, by activation of Erk1/2, Akt, and mTOR. Reduced levels of pAkt and pErk1/2 in IL4Rα knockdown tumor metastases were associated with limited outgrowth, supporting roles for Akt and Erk activation in mediating the tumor-promoting effects of IL4Rα. Collectively, our results offer a preclinical proof-of-concept for targeting IL4/IL4Rα signaling as a therapeutic strategy to limit breast cancer metastasis. Cancer Res; 74(16); 4329–40. ©2014 AACR.
TREATMENT OF FEVER
Authors: D. Buchanan
Journal: BMJ (1922)

MEDICAL JCURW9A&1097 any of the intra-abdominal operations on the round ligaments, and I have seen no instance of failure, even after three subsequent pregnancies.As an indication of the limited number of cases suitable for the Alexander-Adams operation, I would say that in a large yearly operative turn-over in hospital and private, perilaps about twelve cases will be found where the operation can be really recommended.Peradventure even tvelve successful cases per annum in the experience of one operator may lead Sir Williain Smyly and Dr. Bethel Solomons to withllold their thLreatened death-blow from the