tbuckley/cabot-search huggingface dataset:
Plasma clearance kinetics of the amyloid-related high density lipoprotein apoprotein, serum amyloid protein (apoSAA), in the mouse. Evidence for rapid apoSAA clearance.
Authors: J S Hoffman, E P Benditt
Journal: Journal of Clinical Investigation (1983)

The plasma clearance kinetics of the amyloid-related high density lipoprotein (HDL) apoprotein serum amyloid protein (apoSAA) was examined in BALB/c mice by two different methods, using labeled 125I-apoSAA-rich HDL and unlabeled plasma apoSAA (clearance monitored by radioimmunoassay). The plasma half-life of apoSAA, estimated by both methods, was on the order of 75-80 min, as compared with a value of approximately 11 h for mouse apoA-I. In trace-labeling studies, the rapid plasma clearance of both major 125I-labeled apoSAA isotypes was observed; this metabolic behavior was unique to these polypeptides among HDL apoproteins. The property of rapid plasma clearance was lost upon purification and reconstitution of 125I-apoSAA with HDL, indicating that this property is labile to denaturing conditions. Studies aimed at determining the metabolic fate of 125I-apoSAA gave no evidence for either the selective excretion of 125I-apoSAA or clearance to unique tissue sites as compared with other 125I-HDL apoproteins.
5 days of prednisone was noninferior to 14 days in patients with acute COPD exacerbation
Authors: Diego J. Maselli, Jay I. Peters
Journal: Annals of Internal Medicine (2013)

Source Citation Leuppi JD, Schuetz P, Bingisser R, et al. Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE Randomized Clinical Trial. JAMA. 2013;309:2223-31. 23695200
Hairy Cell Leukemia
Authors: HARVEY M. GOLOMB
Journal: Annals of Internal Medicine (1978)

We studied the clinical and laboratory characteristics of 71 patients with hairy cell leukemia to ascertain whether prognostic factors important for the therapy of the disease existed. Granulocytopenia of less than 500/µ1 was associated with the occurrence of a serious infection in 46% of the patients, compared to 19% of patients whose absolute granulocyte count was greater than 500/µ1 (P < 0.05). In most patients with symptoms of thrombocytopenia or leukopenia, splenectomy led to improved blood counts. Patients treated with splenectomy only had a significantly longer survival than those treated with steroids only (P < 0.05). A group of patients who were slightly older and had minimal splenomegaly and few hairy cells in the peripheral blood did well without therapeutic intervention. Twenty-four patients have died, 16 of an infectious process. The actuarial survival for the group is 51% at 4 years, and there has been no change subsequently.
Therapeutic choices not always predictable
Authors: B. Bolsen
Journal: JAMA (1982)

Reports of three studies were presented to a medical technology symposium at the 1982 meeting of the American Association for the Advancement of Science. Given a hypothetical choice between cancer therapy by surgery or by radiation, some subjects were strongly influenced by whether the information was presented in terms of probability of death or survival and by whether the treatments were named. A comparison of the adoption of hospital technologies in states with traditional reimbursement systems and those with prospective reimbursement did not show the expected cost-reducing results. Thirdly, the use of more efficient clinical laboratory equipment has led to increased and often irrelevant testing.
Sharing patient information electronically throughout NHS: Ability to provide seamless decision support will be key factor
Authors: P Ramnarayan
Journal: BMJ (2003)

Editor—Booth's editorial is timely and raises several important issues.1 Although clinicians have to assume a prominent role in planning and implementing a new integrated care record service, they should also be convinced why keeping patients' records electronically is useful.2

Booth details the advantage of being able to share patient data, improve clinical and workflow efficiency, and reduce medical errors. Clinicians are also interested in how it will help with their clinical workflow. Safe care for patients now requires a degree of individualisation that is impossible without computerised clinical decision support.3

As active clinical practitioners involved in the development of a decision support system for paediatrics (ISABEL, www.isabel.org.uk),4 we believe that the ability to provide seamless decision support in practice will be the key to clinician satisfaction with the new system. This approach allows the implementation of evidence based decisions supported by the National Institute for Clinical Excellence, reduces medical error rates, and enables easy dissemination of lessons learnt from error into clinical workflow.

Advanced decision support will also allow knowledge delivery from textbooks and journals to the point of care. By using sophisticated pattern analysis software, data captured in the spine and the integrated care record service can be used for real time epidemiological surveillance. Public health problems, adverse events, and emerging clinical paradigms can be monitored and evoke swift remedial responses. The realisation of this vision will satisfy clinicians and promote successful implementation of the new integrated care record service.
The Use of Experience
Authors: H. Ogilvie
Journal: BMJ (1949)

We are constantly receiving impressions by all our senses- by touch, sight, sound, taste, and smell-and all these impressions are experience.The baby starts to convert experience into knowledge: before it can talk it is already grouping impressions by their likeness or their difference, and forming vague conceptions like " mother," " food and hunger," "dangerous and friendly."The growing child, the adolescent, the grown man and woman, continue the same process.Impressions crowd in upon them, giving them the raw material-experience-which is converted into the finished article-knowledge-in the factory of the mind.Experience comes to all.It comes equally to rich and poor, old and young, just and unjust.Yet some learn from it no more than a reflex existence, the knowledge to eat and sleep and breed, to read the thoughts of others on the printed page or live the emotions of others on the lighted screen, to exchange a small assortment of hackneyed phrases with other robots.Some build up knowledge and become wise: they develop a personal outlook that enriches others and adds to the store of their time.The reason for these differences lies not in the quality of the seed but in that of the soil on which it falls.Impressions are fleeting things.They cannot live unless they are welcomed, studied, com- pared, classified, and grouped.Experience can be made useful only by certain qualities of the mind, some given by inheritance, some by parental example, some by the influence of teachers or writers.Failure to Learn from Experience People fail to learn from experience for three reasons.First, because they have not learned the habit of thought.They bolt their impressions without savouring them, as a dog bolts his food.They do not take their raw material into the factory, but let it pass straight from the delivery gate to the refuse dump.They never classify-that is, they never say to themselves, " Something like this happened before in the same circumstances."Thus they never take the next step, from experience to experiment, to decid- ing, by repeating the circumstances, whether the likeness observed between two experiences was an accident or a consequence.Secondly, because they have classified too much, or rather because they have allowed their habits of thought to become automatic.They have organized their factory for mass production, so that it cannot deal with the unusual order.
Intact Physiological Response to Arousal with Impaired Emotional Recognition in Alexithymia
Authors: Linda A. Stone, Kristy A. Nielson
Journal: Psychotherapy and Psychosomatics (2001)

&lt;i&gt;Background: &lt;/i&gt;The purpose of the present study was to clarify the relationship between the recognition of emotion and physiological response to emotion (i.e. arousal) in alexithymia. &lt;i&gt;Methods:&lt;/i&gt; This study investigated differences in physiological arousal state, as measured by continuous heart rate, electrodermal activity (EDA) and self-reported emotional intensity before and after exposure to an emotionally arousing or neutral videotape among 41 high- or low-alexithymic young adult participants. &lt;i&gt;Results:&lt;/i&gt; Across subjects, emotionally negative stimuli produced increased physiological arousal. However, high-alexithymic participants exposed to the arousing videotape did not report increased subjective emotional intensity, as did low-alexithymic participants. In addition, the baseline EDA of high-alexithymic participants was significantly higher than that of the low-alexithymic participants. &lt;i&gt;Conclusions:&lt;/i&gt; Results support the prediction that alexithymia leads to a decoupling between subjective and physiological arousal when exposed to emotionally negative stimuli. This decoupling may increase alexithymic individuals’ risks for stress-related illness.
THE KEEN OPERATION FOR CICATRICIAL TRACHEAL STENOSIS
Authors: Chevalier Jackson
Journal: JAMA (1924)

The purpose of this report is to call attention to a unique operation devised by W. W. Keen for cicatricial tracheal stenosis, which was reported at the time, twenty-five years ago,<sup>1</sup>but which seems to have been buried in the enormous mass of surgical literature. The cicatricial stenoses resulting from industrial and war injuries render it of timely importance that attention be called to the procedure. Mrs. M., aged 41, was referred to the Bronchoscopic Clinic, Dec. 24, 1919, by Dr. George Fetterolf for the treatment of dyspnea so severe that walking at a slow pace caused weakness, and exertion of any kind was avoided. Indrawing at the guttural fossa, around the clavicles, and in the intercostal spaces called for tracheotomy, which, however, we were able to avoid through the prompt relief afforded by peroral tracheal bouginage. The patient gave the history of having had an operation performed by
Patient package inserts.
Authors: E D Myers, E J Calvert
Journal: BMJ (1978)

Menstrual problems in women starting or changing pill No(% Regimen No of complaining women of menstrual problems Women first starting pill (on lst day of cycle) 228 47 (21) Women changing pill: Starting new pill on 1st day of cycle 125 23 (18) Starting new pill immediately 214 31 (15) Total 567 101 (18)clinic for their three-monthly appointment and about whom, therefore, we have no informa- tion.The table summarises the results for the remaining 567 women, none of whom became pregnant.Of the 101 women complaining of menstrual problems, 82 had spotting or breakthrough bleeding, 10 had amenorrhoea, and 9 had heavy periods.Although we did not include a control group in our study, the rate ofreporting of menstrual problems (18%) is not abnormally high in comparison with the rates reported during the first cycle of use of low-dose contraceptives in other investigations.2-4Seventeen doctors using the new regimens were asked their opinion of them; 15 thought they worked well, particularly the "immediate change-over" regimen.It was found to be easier to persuade patients to switch to lower- dose pills if extra precautions were not needed.Patients liked the new regimens and were not upset by spotting or breakthrough bleeding.Since an average supply of sheaths and pessaries for two weeks costs about C1, a saving of £645 was made during the course of the study.Though the manufacturers of pills have expressed their opposition to the new regimens,-' we believe them to be effective, acceptable, and economical.
1161 ESTIMATED RIBAVIRIN CONCENTRATION IS THE FACTOR MOST INFLUENCING THE EARLY ONSET OF ANEMIA DURING PEG-IFN PLUS RIBAVIRIN THERAPY IN OLD (&gt;50 YEARS) G1 CHC PATIENTS
Authors: G. Spinzi, G. Borroni, M. Andreoletti, A. Bortoli, M.A. Casiraghi, M. Cazzaniga, R. Ceriani, P. Guerzoni, M.G.L. Pich, B. Omazzi, S. Paggi, A. Prada, N. Terreni
Journal: Journal of Hepatology (2012)
What's wrong with the funding of cancer research?
Authors: P Hugh-Jones
Journal: BMJ (1982)

is a strong feeling in New Zealand that such a scheme will come eventually.There is little pressure in Britain at the moment for creating a no-fault scheme for compensating disability.Indeed, consumer pressure groups are pushing in the opposite direction-towards an enhanced legal system-when it comes to compensation for product injury.I My experience of the chaos in America-where strict liability prevails-convinces me that progress towards a full no-fault system could be much preferable.This is the second of three articles.
Sumatriptan-Naproxen for Acute Treatment of Migraine
Authors: Jan Lewis Brandes, David Kudrow, Stuart R. Stark, C. Phillip O’Carroll, James U. Adelman, Francis J. O’Donnell, W. James Alexander, Susan E. Spruill, Pamela S. Barrett, Shelly E. Lener
Journal: JAMA (2007)

Multiple pathogenic mechanisms may be involved in generating the migraine symptom complex, and multimechanism-targeted therapy may confer advantages over monotherapy.To evaluate the efficacy and safety of a fixed-dose tablet containing sumatriptan succinate and naproxen sodium relative to efficacy and safety of each monotherapy and placebo for the acute treatment of migraine.Two replicate, randomized, double-blind, single-attack, parallel-group studies conducted among 1461 (study 1) and 1495 (study 2) patients at 118 US clinical centers who were diagnosed as having migraine and received study treatment for a moderate or severe migraine attack.Patients were randomized in a 1:1:1:1 ratio to receive a single tablet containing sumatriptan, 85 mg, and naproxen sodium, 500 mg; sumatriptan, 85 mg (monotherapy); naproxen sodium, 500 mg (monotherapy); or placebo, to be used after onset of a migraine with moderate to severe pain.Primary outcome measures included the percentages of patients with headache relief 2 hours after dosing, absence of photophobia, absence of phonophobia, and absence of nausea for the comparison between sumatriptan-naproxen sodium and placebo, and the percentages of patients with sustained pain-free response for the comparison between sumatriptan-naproxen sodium and each monotherapy.Sumatriptan-naproxen sodium was more effective than placebo for headache relief at 2 hours after dosing (study 1, 65% vs 28%; P<.001 and study 2, 57% vs 29%; P<.001), absence of photophobia at 2 hours (58% vs 26%; P<.001 and 50% vs 32%; P<.001), and absence of phonophobia at 2 hours (61% vs 38%; P<.001 and 56% vs 34%; P<.001). The absence of nausea 2 hours after dosing was higher with sumatriptan-naproxen sodium than placebo in study 1 (71% vs 65%; P = .007), but in study 2 rates of absence of nausea did not differ between sumatriptan-naproxen sodium and placebo (65% vs 64%; P = .71). For 2- to 24-hour sustained pain-free response, sumatriptan-naproxen sodium was superior at P<.01 (25% and 23% in studies 1 and 2, respectively) to sumatriptan monotherapy (16% and 14% in studies 1 and 2), naproxen sodium monotherapy (10% and 10% in studies 1 and 2), and placebo (8% and 7% in studies 1 and 2). The incidence of adverse events was similar between sumatriptan-naproxen sodium and sumatriptan monotherapy.Sumatriptan, 85 mg, plus naproxen sodium, 500 mg, as a single tablet for acute treatment of migraine resulted in more favorable clinical benefits compared with either monotherapy, with an acceptable and well-tolerated adverse effect profile.clinicaltrials.gov Identifiers: NCT00434083 (study 1); NCT00433732 (study 2).
My Father Is a Dancer
Authors: Bradley Anderson
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe bone disease and low bone mineral density after juvenile renal failure
Authors: Jaap W. Groothoff, Martin Offringa, Berthe L.F. van Eck-Smit, Mariken P. Gruppen, Nicole J. van de Kar, Eric D. Wolff, Marc R. Lilien, Jean Claude Davin, Hugo S.A. Heymans, Friedo W. Dekker
Journal: Kidney International (2003)
Oral peanut immunotherapy in children with peanut anaphylaxis
Authors: Katharina Blumchen, Helen Ulbricht, Ute Staden, Kerstin Dobberstein, John Beschorner, Lucila Camargo Lopes de Oliveira, Wayne G. Shreffler, Hugh A. Sampson, Bodo Niggemann, Ulrich Wahn, Kirsten Beyer
Journal: Journal of Allergy and Clinical Immunology (2010)
Updating The International Classification of Diseases
Authors: STEVEN J. ROSANSKY
Journal: Annals of Internal Medicine (1980)

Letters1 March 1980Updating The International Classification of DiseasesSTEVEN J. ROSANSKY, M.D.STEVEN J. ROSANSKY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-3-437_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the October issue, two articles, by Payne (1) and Stern (2), bring attention to the written medical record as a means of evaluating physician performance and as a tool for epidemiologic research. This potential usefulness of the medical record can be reduced by a major shortcoming I recently encountered.When a patient is discharged from the hospital, the physician summarizes his course and lists the final diagnoses. Medical record librarians code these diagnoses for morbidity and mortality statistics. Unfortunately, the list of diagnostic categories used for this task may have little relevance to contemporary clinical medicine....References1. PAYNE B. The medical record as a basis for assessing physician competence. Ann Intern Med. 1979;91:623-9. LinkGoogle Scholar2. STERN M. The recent decline in ischemic heart disease mortality. Ann Intern Med. 1979;91:630-40. LinkGoogle Scholar3. . The International Classification of Diseases, Clinical Modification. 9th ed. Ann Arbor: Edwards Brothers; 1978: vol. 1, p. xx. Google Scholar4. . The International Classification of Diseases, Adapted. 8th ed. Washington, D.C.: U.S. Government Printing Office; 1968; vol. 2, p. vii. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Renal Disease Section, William Jennings Bryan Dorn Veterans Administration Hospital Columbia, SC 29201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1980Volume 92, Issue 3Page: 437-437KeywordsDiagnostic medicineEpidemiologyInternational Classification of DiseasesMorbidityMortality Issue Published: 1 March 1980 PDF DownloadLoading ...
The Torturer's Horse
Authors: Emily Friedman
Journal: JAMA (1989)

Noncoverage of the costs of care for the uninsured poor and their resultant lack of access to health care affect every American through the spread of disease, risk of dangerous behavior by the untreated mentally ill, and the slowing of American productivity and competitiveness. Insured, middle-class Americans must recognize that the low-income uninsured are not someone else's problem, and that the "us and them" attitude underlying medical indigence will ultimately present an enormous cost that we all pay -- both in the last-minute care provided in costly hospital settings and in the effects of our cruelty toward the most fragile members of our society.
Progress report. Diagnosis of insulinoma.
Authors: V Marks
Journal: Gut (1971)

Progress report Diagnosis of insulinomaInsulinoma is a term used by clinicians and biochemists to describe the (usually) small tumours composed of islet cell tissue that develop in the pancreas and ectopic sites, and which manifest themselves almost exclusively by their ability to secrete insulin and produce 'spontaneous' hypoglycaemia.' Though often described as P-cell tumours, insulinomas only rarely consist
A dual-binding antibody to E- and L-selectin attenuates sepsis-induced lung injury.
Authors: P C Ridings, A C Windsor, M A Jutila, C R Blocher, B J Fisher, M M Sholley, H J Sugerman, A A Fowler
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Many studies indicate a pivotal role for neutrophil adhesion in sepsis-associated lung injury. Neutrophil adhesion to endothelium depends on activation and expression of selectin and integrin adhesion receptors. We studied the effects of pretreatment with a dual-binding porcine anti-E- and anti-L-selectin monoclonal antibody (EL-246) on a porcine model of sepsis-induced lung injury. Four groups were studied for 5 h. Group 1 (control animals) received intravenous saline only. Group 2 (septic) received a 1-h infusion of Pseudomonas aeruginosa. Group 3 (EL-246 pretreatment) received EL-246 (1 mg/kg) prior to Pseudomonas infusion. Group 4 (EL-246 controls) received EL-246 infusion only. Group 2 animals showed rapid, significant decline in arterial pH and oxygen tension whereas, in Group 3, physiologic deterioration was significantly attenuated. Bronchoalveolar lavage at 5 h showed a significant increase in neutrophil count and protein content in Group 2. Group 3, however, showed no significant differences in these parameters compared with control animals. Despite severe neutropenia, lung myeloperoxidase content at 5 h was significantly reduced in Group 3 compared with Group 2. There was no significant difference in pulmonary and systemic hemodynamics between Groups 2 and 3. Group 4 animals exhibited a transient neutropenia, but otherwise no other differences in measured parameters were found compared with Group 1 control animals. In conclusion, EL-246 significantly reduced neutrophil accumulation in lung and attenuated sepsis-induced lung injury, but failed to attenuate deranged pulmonary and systemic hemodynamics.(ABSTRACT TRUNCATED AT 250 WORDS)