tbuckley/cabot-search huggingface dataset:
Endoscopic retrieval method using a small grip-seal plastic bag for large colorectal resection specimens after endoscopic submucosal dissection
Authors: S. Tanaka, T. Toyonaga, J. East, D. Obata, S. Fujiwara, C. Wakahara, A. Masuda, M. Man-i, Y. Morita, T. Sanuki, T. Fujita, M. Yoshida, H. Kutsumi, T. Azuma
Journal: Endoscopy (2010)

Endoscopic submucosal dissection (ESD) has recently been developed for endoscopic treatment of colorectal polyps, enabling en bloc resection regardless of size and shape [1] [2]. However, it is often difficult to retrieve a large resected colorectal specimen after ESD without damage to the specimen by the anal sphincter muscle. Here, we report an effective technique to retrieve a large colorectal resected specimen after ESD without damage.
Structure-Activity–Dependent Regulation of Cell Communication by Perfluorinated Fatty Acids using <i>in Vivo</i> and <i>in Vitro</i> Model Systems
Authors: Brad L. Upham, Joon-Suk Park, Pavel Babica, Iva Sovadinova, Alisa M. Rummel, James E. Trosko, Akihiko Hirose, Ryuichi Hasegawa, Jun Kanno, Kimie Sai
Journal: Environmental Health Perspectives (2008)

Perfluoroalkanoates, [e.g., perfluorooctanoate (PFOA)], are known peroxisome proliferators that induce hepatomegaly and hepatocarcinogenesis in rodents, and are classic non-genotoxic carcinogens that inhibit in vitro gap-junctional intercellular communication (GJIC). This inhibition of GJIC is known to be a function of perfluorinated carbon lengths ranging from 7 to 10.The aim of this study was to determine if the inhibition of GJIC by PFOA but not perfluoropentanoate (PFPeA) observed in F344 rat liver cells in vitro also occurs in F344 rats in vivo and to determine mechanisms of PFOA dysregulation of GJIC using in vitro assay systems.We used an incision load/dye transfer technique to assess GJIC in livers of rats exposed to PFOA and PFPeA. We used in vitro assays with inhibitors of cell signaling enzymes and antioxidants known to regulate GJIC to identify which enzymes regulated PFOA-induced inhibition of GJIC.PFOA inhibited GJIC and induced hepatomegaly in rat livers, whereas PFPeA had no effect on either end point. Serum biochemistry of liver enzymes indicated no cytotoxic response to these compounds. In vitro analysis of mitogen-activated protein kinase (MAPK) indicated that PFOA, but not PFPeA, can activate the extracellular receptor kinase (ERK). Inhibition of GJIC, in vitro, by PFOA depended on the activation of both ERK and phosphatidylcholine-specific phospholipase C (PC-PLC) in the dysregulation of GJIC in an oxidative-dependent mechanism.The in vitro analysis of GJIC, an epigenetic marker of tumor promoters, can also predict the in vivo activity of PFOA, which dysregulated GJIC via ERK and PC-PLC.
An abnormal collagen alpha chain containing cysteine in autosomal dominant osteogenesis imperfecta.
Authors: A C Nicholls, F M Pope, D Craig
Journal: BMJ (1984)

Une observation chez un garcon de 11 ans atteint d'osteogenese imparfaite de type I d'apres la classification de Sillence. Mise en evidence de l'anomalie par electrophorese sur gel de dodecylsulfate-polyacrylamide
Association between haplotypes of genetic polymorphisms of IL-13 and GM-CSF and atopy, airway hyperresponsiveness, and atopic asthma
Authors: S. Kim, H. Park, Y. Kwon, Y. Chung, T. Kim, H. Park, S. Oh, J. Bahn, J. Lee, H. Oh, E. Shin, J. Lee, Y. Chang, Y. Kim, S. Cho, K. Min, Y. Kim
Journal: Journal of Allergy and Clinical Immunology (2005)
Ionisers in the management of bronchial asthma.
Authors: S G Nogrady, S B Furnass
Journal: Thorax (1983)

Because of recent interest in the possible benefits to asthmatic patients of negative ion generators and the largely uncontrolled and inconclusive nature of earlier studies a double blind crossover study of this treatment was carried out in 20 subjects with stable asthma over six months. After an initial two week period without an ioniser, active or placebo ionisers were installed in subjects' bedrooms for two eight week periods separated by a four week "washout" period when no ioniser was present. The study was completed by a final four week period when no ioniser was present. Subjects were randomly allocated to receive an active or a placebo ioniser first. Subjects recorded their peak expiratory flow rate (PEFR) twice daily, completed a daily symptom score questionnaire, and noted any treatment they took on a diary card. Recordings were completed throughout the trial. Ion counts and dust concentrations were measured in subjects' bedrooms during the study. Mean ion counts rose considerably when ionisers were activated (p less than 0.001). There were no significant differences in PEFR, symptom score, or consumption of medication between the periods that active ionisers and either no ionisers or placebo ionisers were in operation. This study has failed to show a statistically significant benefit in asthmatic subjects from the use of negative ion generators.
Hemoglobinemia and the Hemoglobinurias
Authors: Joseph F. Ross
Journal: New England Journal of Medicine (1945)

BLACKWATER, or more scientifically, hemoglobinuria, attracts the attention of patient and physician as do few other symptoms. Indeed, few other symptoms indicate so serious a disturbance of body processes or carry so grave a prognosis. The diseases producing or associated with hemoglobinuria, with some exceptions, usually either have a high fatality rate or are extremely chronic and disabling.It is the purpose of this paper to review the mechanisms by which hemoglobinuria is produced, to consider its pathologic effects and to summarize the important features of the clinical syndromes that lead to the excretion of hemoglobin in the urine.Pathologic . . .
A quantitative index of regional blood flow in canine myocardium derived noninvasively with N-13 ammonia and dynamic positron emission tomography
Authors: Christoph A. Nienaber, Osman Ratib, Sanjiv S. Gambhir, Janine Krivokapich, Sung-cheng Huang, Michael E. Phelps, Heinrich R. Schelbert
Journal: Journal of the American College of Cardiology (1991)
Increased circulating activated endothelial cells, vascular endothelial growth factor, and tumor necrosis factor in thalassemia
Authors: Punnee Butthep, Saknarong Rummavas, Raewadee Wisedpanichkij, Sumalee Jindadamrongwech, Suthat Fucharoen, Ahnond Bunyaratvej
Journal: American Journal of Hematology (2002)

Abstract An increased number of circulating endothelial cells (CECs) was demonstrated in α‐ and β‐thalassemic patients, β‐thalassemia/hemoglobin E (BE), both splenectomized (BE[S]) and non‐splenectomized (BE[NS]), had higher numbers of CECs than α‐thalassemia, both HbH (α‐thal l/α‐thal 2; H) and HbH with hemoglobin Constant Spring (α‐thal 1/CS; H/CS). CECs were also increased in heterozygous HbE (EA) and homozygous HbE (EE). The highest level of tumor necrosis factor‐α (TNF‐α) was found in HbH/CS patients, whereas the highest levels of vascular endothelial growth factor (VEGF) was observed in BE[S] patients. Significant decreases, in protein C and protein S levels were found in both α‐ and β‐thalassemia compared with normal. Good correlations between the numbers of CEC and TNF‐α, VEGF, protein C, and protein S levels were demonstrated in this study. In addition, markers for endothelial cell activation and injury (intercellular adhesion molecule‐1, ICAM‐1/CD54; vascular cell adhesion molecule‐1, VCAM‐1/CD106; and E‐selectin, ELAM‐1/CD62E) were detected on the surface of isolated CECs using immunofluorescence technique. Appearance of CECs with markers for endothelial cell activation, together with increased levels of TNF‐α and VEGF and decreased levels of protein C and protein S in the circulation, may account for the propensity of vascular perturbation in thalassemic subjects. Am. J. Hematol. 70:100–106, 2002. © 2002 Wiley‐Liss, Inc.
Abstract 223: High-throughput drug discovery against breast cancer stem cells
Authors: Sean P. McDermott, Fatou Ndaw, Alexandra Fox, Steve R. Vander Roest, Martha J. Larsen, Max S. Wicha
Journal: Cancer Research (2014)

Abstract The cancer stem cell (CSC) hypothesis postulates that tumors are maintained by a self-renewing CSC population that is also capable of differentiating into non-self renewing cell populations that constitute the bulk of the tumor. Clinically, CSCs are predicted to mediate tumor recurrence after chemotherapy and radiotherapy due to the relative inability of these modalities to effectively target CSCs. Therefore, new therapies that target CSC must be developed and combined with standard therapy to achieve a true cure. Targeting breast CSC represents an attractive avenue for developing therapeutics; however, there are multiple pools of breast CSCs utilizing distinct signaling pathways, such as Wnt/β-catenin &amp; NF-κB. These breast CSC pools are identified using flow cytometry as cells with high expression of aldehyde dehydrogenase (ALDH), CD44+CD24-, or CD90+. We have developed a high-throughput flow cytometry based screen against CD90+ breast CSCs. We screened ∼18,500 small molecules for inhibitors of CD90+ frequency and identified 19 compounds. Here, we will present data examining this compounds against ALDH+, and CD44+CD24- breast CSCs. By identifying compounds with that target multiple pools of breast CSCs, these compounds might be exploited in future drug development endeavors. Citation Format: Sean P. McDermott, Fatou Ndaw, Alexandra Fox, Steve R. Vander Roest, Martha J. Larsen, Max S. Wicha. High-throughput drug discovery against breast cancer stem cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 223. doi:10.1158/1538-7445.AM2014-223
Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors
Authors: Meili Zhang, Zhengsheng Yao, Zhuo Zhang, Kayhan Garmestani, Carolyn K. Goldman, Jeffrey V. Ravetch, John Janik, Martin W. Brechbiel, Thomas A. Waldmann
Journal: Blood (2006)
Two New Projects to Help Native Americans End Substance Abuse and Domestic Violence
Authors: M. Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effect of bacterial products on human fibroblast and keratinocyte detachment and viability
Authors: D. TAYLOR, C. WHATLING, J.N. KEARNEY, B. MATTHEWS, K.T. HOLLAND
Journal: British Journal of Dermatology (1990)

An in vitro model has been developed to study the effect of soluble bacterial products on the viability and detachment of skin cell types utilized for cultured grafts. Microbial products prepared from clinical isolates of bacterial species which most commonly colonize burn lesions showed marked variation in their ability to detach and kill both keratinocytes and fibroblasts. All three isolates of Acinetobacter spp. tested were effective in causing detachment and death of keratinocytes and fibroblasts, whereas Escherichia coli, Proteus mirabilis and Enterobacter spp. tested had little, or no, effect on detachment or viability for either skin cell type. Four Staphylococcus aureus isolates elicited variable strain‐dependent results with regard to detachment and viability. One isolate possessed activity specific for keratinocyte detachment and death. These results indicate the possible undesirable effects such bacterial species may have on graft success in colonized burn wounds.
Healthy Neighborhoods: Walkability and Air Pollution
Authors: Julian D. Marshall, Michael Brauer, Lawrence D. Frank
Journal: Environmental Health Perspectives (2009)

BackgroundThe built environment may influence health in part through the promotion of physical activity and exposure to pollution. To date, no studies have explored interactions between neighborhood walkability and air pollution exposure.MethodsWe estimated concentrations of nitric oxide (NO), a marker for direct vehicle emissions), and ozone (O3) and a neighborhood walkability score, for 49,702 (89% of total) postal codes in Vancouver, British Columbia, Canada. NO concentrations were estimated from a land-use regression model, O3 was estimated from ambient monitoring data; walkability was calculated based on geographic attributes such as land-use mix, street connectivity, and residential density.ResultsAll three attributes exhibit an urban–rural gradient, with high walkability and NO concentrations, and low O3 concentrations, near the city center. Lower-income areas tend to have higher NO concentrations and walkability and lower O3 concentrations. Higher-income areas tend to have lower pollution (NO and O3). "Sweet-spot" neighborhoods (low pollution, high walkability) are generally located near but not at the city center and are almost exclusively higher income.Policy implicationsIncreased concentration of activities in urban settings yields both health costs and benefits. Our research identifies neighborhoods that do especially well (and especially poorly) for walkability and air pollution exposure. Work is needed to ensure that the poor do not bear an undue burden of urban air pollution and that neighborhoods designed for walking, bicycling, or mass transit do not adversely affect resident's exposure to air pollution. Analyses presented here could be replicated in other cities and tracked over time to better understand interactions among neighborhood walkability, air pollution exposure, and income level.
Vocal learning, prosody, and basal ganglia: Don't underestimate their complexity
Authors: Andrea Ravignani, Mauricio Martins, W. Tecumseh Fitch
Journal: Behavioral and Brain Sciences (2014)

Ackermann et al.'s arguments in the target article need sharpening and rethinking at both mechanistic and evolutionary levels. First, the authors' evolutionary arguments are inconsistent with recent evidence concerning nonhuman animal rhythmic abilities. Second, prosodic intonation conveys much more complex linguistic information than mere emotional expression. Finally, human adults' basal ganglia have a considerably wider role in speech modulation than Ackermann et al. surmise.
Inhibitory effect of magnesium l-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo
Authors: Koichiro Kameyama, Chie Sakai, Shigeo Kondoh, KohZoh Yonemoto, Shigeo Nishiyama, Masato Tagawa, Tomoji Murata, Toshio Ohnuma, John Quigley, Albert Dorsky, Daniel Bucks, Kurt Blanock
Journal: Journal of the American Academy of Dermatology (1996)
Influence of albumin on the net sinusoidal efflux of the organic anion dibromosulfophthalein from rat liver
Authors: Henricus M. J. Nijssen, Tjaard Pijning, Dirk K. F. Meijer, Geny M. M. Groothuis
Journal: Hepatology (1992)

Besides being excreted into bile, several anionic drugs and anionic drug conjugates are excreted from liver into plasma by a carrier-mediated process (sinusoidal efflux). In the study presented here, we investigated the influence of albumin on the net sinusoidal efflux of an organic anion from isolated perfused liver, with net sinusoidal efflux defined as the resultant of efflux and reuptake. We tested the hypothesis that albumin exerts its effect on net sinusoidal efflux through inhibition of repeat uptake rather than on the sinusoidal efflux process itself. We also studied possible acinar heterogeneity in net sinusoidal efflux rate of the organic anion. Isolated rat livers were preloaded with the nonmetabolizable anionic model compound dibromosulfophthalein in the absence (type I) or presence (type II) of bovine serum albumin. Fluorescence microscopy of dibromosulfophthalein in liver sections showed selective zone 1 loading after type I loading and homogeneous acinar distribution after type II loading. The rate of net sinusoidal efflux and biliary excretion was then studied in single-pass perfusions with various concentrations of bovine serum albumin in the medium. Net sinusoidal efflux of dibromosulfophthalein showed a marked dependence on albumin concentration in both type I and type II experiments. Net efflux rate reached a maximal value at a medium concentration of 300 μmol/L bovine serum albumin and was not increased further at 600 μmol/L. The initial uptake rate of dibromosulfophthalein was not significantly different in the 300 μmol/L and 600 μmol/L bovine serum albumin experiments. We conclude that the net sinusoidal efflux rate of the organic anion from the hepatocyte as measured in perfusion outflow medium is the resultant of an albumin-independent sinusoidal efflux process combined with albumindependent inhibition of reuptake of this material. The relationship between unbound concentration of dibromosulfophthalein in perfusion outflow medium and initial net efflux rate is nonlinear, probably because nonequilibrium conditions exist in the sinusoid, and effluxed dibromosulfophthalein is recaptured by the cells before extracellular binding to albumin can occur. Because no difference was found between efflux in type I and type II perfusions, it was concluded that no acinar heterogeneity exists in transport of dibromosulfophthalein. Surprisingly, the rapid efflux from the cells induced by albumin had virtually no effect on the biliary excretion rate of dibromosulfophthalein. Therefore we conclude that the sinusoidal efflux process is operating from an intracellular pool different from that for biilary excretion.
Abstract P4-05-08: Oncotype Dx assay in BRCA positive ER positive breast cancer patients
Authors: N Halpern, A Sonnenblick, L Kaduori, B Uziely, Y Goldberg, D Katz, T Allweis, L Divinsky, I Merlet, B Maly, M Sagi, T Hamburger, E Carmon, T Peretz
Journal: Cancer Research (2013)

Abstract Background: Oncotype DX is a 21-gene RT-PCR assay which quantifies the likelihood of breast cancer recurrence and the potential benefit of chemotherapy in patients with early stage, ER positive, Tamoxifen treated breast cancer. Breast cancer in BRCA carriers is considered more aggressive. The aim of our study was to evaluate whether Oncotype Dx recurrence score distribution is different in breast cancer patients with inherited BRCA mutation. Methods: The Oncotype DX assay has been used at Hadassah Medical Center since 2004 on specimens from over 450 patients. We analyzed and compared clinicopathological characteristics and Oncotype Dx recurrence scores of BRCA carriers versus non- BRCA or unknown status of BRCA patients. Results: Ten patients had validated inherited BRCA mutation, five of them are BRCA1 carriers and five BRCA2 carriers. There were no significant differences in the clinicopathological characteristics between the two groups. Oncotype Dx recurrence score distribution between low, intermediate and high risk groups was not significantly different. The mean recurrence score was 18.48 for the non- BRCA or unknown status of BRCA patients and 22.8 for the BRCA carriers patients. This difference was not statistically significant. Conclusion: Estrogen receptor positive breast cancer tumors from BRCA carriers does not display a significantly different Oncotype Dx recurrence score result distribution. These preliminary data suggest Oncotype Dx assay might be used to help tailor treatment in this subset of patients, although further follow up is needed. All patients evaluated for oncotype_DX All evaluated (except BRCA+) n = 456BRCA positiveP valueAgeMean57.4557.60.7 Median5857 Range56 (25-81)34 (42-76) T stageT167.7%70%0.9 T230.7%30% T31.6%0% Tumor sizeMean1.71.360.2 Median1.51.26 Range7.8 (0.2-8)1.3 (0.7-2) GradeGrade 1-278.8%60%0.15 Grade 321.2%40% RSLow50%40%0.57 Intermediate39.8%40% High10.2%20% RSMean18.4822.80.16 Median17.522.5 Range64 (0-64)27 (12-39) Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-05-08.
Is Topical δ-Aminolevulinic Acid Adequate for Photodynamic Therapy in Barrett’s Esophagus? A Pilot Study
Authors: M.-A. Ortner, K. Zumbusch, J. Liebetruth, B. Ebert, B. Fleige, M. Dietel, H. Lochs
Journal: Endoscopy (2002)

Background and Study Aims: The methods of endoscopic ablation of metaplastic and dysplastic areas in Barrett's esophagus so far described, are not satisfactory with respect to efficacy and safety. Therefore we investigated whether photodynamic therapy (PDT) with topical δ-aminolevulinic acid (δ-ALA) leads to ablation of specialized columnar epithelium and eradication of low-grade dysplasia while not producing phototoxicity and systemic side effects.
A METHOD OF COUNTING THE ACTUAL NUMBER OF PURKINJE CELLS PRESENT IN A GIVEN AREA OF CEREBELLUM, AND ITS APPLICATION IN TEN CLINICAL CASES
Authors: Frederic Wade Hitchings
Journal: The Journal of Experimental Medicine (1914)

1. This method of determining the actual number of Purkinje cells present in a given area of cerebellum is practicable and of sufficient accuracy to make it another useful means of studying nerve cell activity. 2. In its application to clinical cases it is found that increasing nerve cell exhaustion is accompanied by increasing nerve cell disappearance, although it is recognized that theoretically complete nerve cell exhaustion could be present without nerve cell disappearance on account of the individual dying before phagocytic action could take place. 3. This disappearance of nerve cells corroborates the theories and observations made on phagocytosis of nerve cells, inasmuch as it shows that nerve cells disappear from the brain. 4. While there are too few cases to establish a normal actual Purkinje cell count, it is of interest to note that there were 16.6 per cent. fewer cells in the case with the maximum cell exhaustion (57 per cent.) than in the case of the normal man (2 per cent.).
Toward improved prediction of risk for atopy and asthma among preschoolers: A prospective cohort study
Authors: Patrick G. Holt, Julie Rowe, Merci Kusel, Faith Parsons, Elysia M. Hollams, Anthony Bosco, Kathy McKenna, Lily Subrata, Nicholas de Klerk, Michael Serralha, Barbara J. Holt, Guicheng Zhang, Richard Loh, Staffan Ahlstedt, Peter D. Sly
Journal: Journal of Allergy and Clinical Immunology (2010)
Coronary Risk Factors and Coronary Angiography Results of 12.257 Patients
Authors: Şeyda Günay, Osman Akın Serdar, Sinem Özbay Özyılmaz, Seçkin Dereli, Ali Aydınlar, İbrahim Baran, Bülent Özdemir, Dilek Yeşilbursa, Sümeyye Güllülü
Journal: Journal of the American College of Cardiology (2013)
Letter: Serum creatine phosphokinase and malignant hyperpyrexia.
Authors: D W Ryan, T N Appleyard
Journal: BMJ (1976)

colleagues that routine pelvimetry should be performed only postpartum or after a caesarean section, difficult forceps delivery, or perinatal death.Is it not possible that if we had known about that nasty pelvis before we would not have traumatised or killed the baby delivering it vaginally but have made the correct decision to deliver it abdominally?Surely for a risk of only 1 in 30 000 it is well worth while having this extra piece of information with WMhich to program our personal computer.