Cardiovascular Consequences of Subclinical Thyroid Dysfunction: More Smoke but No Fire
Authors: Paul W. Ladenson
Journal: Annals of Internal Medicine (2008)

Editorials3 June 2008Cardiovascular Consequences of Subclinical Thyroid Dysfunction: More Smoke but No FirePaul W. Ladenson, MDPaul W. Ladenson, MDFrom The Johns Hopkins University School of Medicine, Baltimore, MD 21287-0003.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-11-200806030-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Physicians delight in diagnosing and treating patients with overt thyroid dysfunction—those with a serum thyroxine level above or below the normal range—expecting that most or all of their symptoms will resolve and that serious, even life-threatening, complications will be avoided. At the same time, physicians recommend that individuals who have symptoms or such conditions as hypercholesterolemia, heart failure, atrial fibrillation and osteoporosis, but also normal free thyroxine and thyroid-stimulating hormone (TSH) levels, seek nonthyroidal causes and solutions for their clinical problems. Physicians remain uncertain, however, whether to treat patients who have pituitary thyrotropic cells that show that their thyroid hormone ...References1. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87:489-99. [PMID: 11836274] CrossrefMedlineGoogle Scholar2. Helfand M, Redfern CC. Clinical guideline, part 2. Screening for thyroid disease: an update. American College of Physicians. Ann Intern Med. 1998;129:144-58. [PMID: 9669977] LinkGoogle Scholar3. 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Singh S, Duggal J, Molnar J, Maldonado F, Barsano CP, Arora R. Impact of subclinical thyroid disorders on coronary heart disease, cardiovascular and allcause mortality: a meta-analysis. Int J Cardiol. 2008;125:41-8. [PMID: 17434631] CrossrefMedlineGoogle Scholar16. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med. 2000;132:270-8. [PMID: 10681281] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From The Johns Hopkins University School of Medicine, Baltimore, MD 21287-0003.Disclosures: None disclosed.Corresponding Author: Paul W. Ladenson, MD, Division of Endocrinology and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, MD 21287-0003; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-analysis: Subclinical Thyroid Dysfunction and the Risk for Coronary Heart Disease and Mortality Nicolas Ochs , Reto Auer , Douglas C. Bauer , David Nanchen , Jacobijn Gussekloo , Jacques Cornuz , and Nicolas Rodondi Metrics Cited ByAssociation of endemic goitre and exceptional longevity in Sardinia: evidence from an ecological studyEffect of Thyroxin Treatment on Carotid Intima–Media Thickness (CIMT) Reduction in Patients with Subclinical Hypothyroidism (SCH): a Meta-Analysis of Clinical TrialsThyroid Hormone Profile in Patients With Acute Coronary SyndromeRelación entre la concentración plasmática de tirotropina y enfermedad cardiovascular (Cohorte Camargo)Non-malignant Thyroid Diseases after a Wide Range of Radiation ExposuresRelationship Between Subclinical Thyroid Dysfunction and Heart Failure and Mortality 3 June 2008Volume 148, Issue 11Page: 880-881KeywordsCohort studiesElderlyHypothyroidismThyroidThyroid hormonesThyroid-stimulating hormoneThyroxine ePublished: 3 June 2008 Issue Published: 3 June 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...