tbuckley/cabot-search huggingface dataset:
Abstract 556: Extracellular sulfatase 2; enzymatic inhibition by OKN-007 a disulfonylphenyl nitrone with anticancer activity and other sulfamate and sulfone compounds
Authors: Robert A. Floyd, Hema K. Chandru, Rheal A. Towner
Journal: Cancer Research (2011)

Abstract Sulfatase 2 (Sulf2) is an extracellular enzyme which catalyzes the removal of 6-O-sulfate groups on glucosamine from subregions of the glycosaminoglycan heparin sulfate. Sulf2 action alters the binding of protein ligand growth factors such as VEGF, FGF-2, TGF and SDF-1 to heparin and cellular receptors. Sulf2 is enriched in several tumors including breast cancer, pancreatic cancer, lung cancer and liver cancer and studies in experimental models have shown its action is important in cancer development. We have shown that PBN (α-phenyl-tert-butylnitrone) nitrones have anti-cancer activity in experimental cancer models including the rat choline deficiency liver cancer model, the mouse APCmin model of colon cancer and the rat C6 glioma model. Studies of the PBN derivative 2,4-disulfonylphenyl-tert-butylnitrone in the C6 glioma model showed that it has more potent anti-cancer activity in this model than PBN. We considered that the sulfonyl groups on OKN-007 acting to inhibit the activity of Sulf2 could account for its anti-cancer activity and therefore set up experiments to test this concept. We have shown that OKN-007 does inhibit Sulf2 at biological meaningful concentrations. In addition we have partially completed an MCF-7 xenograph study that indicates OKN-007 administered orally does suppress cancer growth in this model. We have also shown that another compound suramin that has 6 sulfonyl groups and has been shown to have anti-cancer activity also suppressed the enzymatic activity of Sulf2. In addition we have also tested some compounds that have sulfamate and sulfone functional groups and have found that they also show some activity in suppressing the enzymatic action of Sulf2. Studies are continuing to elucidate the significance of the action of OKN-007 on Sulf2. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 556. doi:10.1158/1538-7445.AM2011-556
Medical Maladies as Seen by the Artist
Authors: John H. Talbott
Journal: JAMA (1981)

Despite rewarding but sporadic attempts by a few physicians to identify and document the specifics of medical afflictions as they have been seen through the eyes of the artist, a treasure trove of real or symbolic depiction of disease still lies fallow in museums and galleries throughout the world. Gout, a readily recognized type of arthritis, is a notable example, especially as portrayed in England in the caricatures of the early part of the 19th century. In a delightful essay titled "Gout in the Time and Person of George IV: A Case History," Bywaters<sup>1</sup>reproduced a number of caricatures in color of Arbuthnot's John Bull or the real Prince Regent, later George IV, afflicted with chronic tophus gout. The Cruickshanks and Rowlandson, Gillray, and others were particularly prolific at this time in their portrayal of the miseries of gout (see, eg, covers Jan 23, 1967; Feb 5, 1969; Feb
Cancer risk assessment and prevention: where do we stand?
Authors: A S Whittemore
Journal: Environmental Health Perspectives (1989)

This paper reviews selected aspects of progress and setbacks in cancer risk assessment and prevention during the four decades since the founding in 1947 of the Institute of Environmental Medicine at the New York University Medical Center. The period has been marked by substantial gains in quantifying the risks posed by exposures to known human carcinogens such as tobacco and ionizing radiation. By contrast, the search for sensitive and specific laboratory screens for human carcinogens has met setbacks, and epidemiological data still are needed to monitor the adverse effects of environmental exposures. The determination of acceptable levels of exposure to potential human carcinogens remains a formidable task, one for which no scientific framework yet exists. Future challenges in cancer risk assessment include the validation and use of biological markers of exposure and effective monitoring of risk among exposed populations. Future challenges in cancer prevention include the elimination of tobacco consumption and the acquisition of knowledge needed to prevent nutritionally and hormonally related cancers such as cancers of the bowel, prostate, and breast.
Potential Fire Hazard In Defibrillation
Authors: Paul H. Miller
Journal: JAMA (1972)

To the Editor.—  The following report is presented to emphasize the increased risk for fire that exists within the Cardiac Care Unit.  Report of a Case.—  A 73-year-old woman with arteriosclerotic heart disease was admitted with a four-day history of increasing dyspnea. On the seventh hospital day, cardiac arrest occurred. Cardiopulmonary resuscitation was successful and she was sent immediately to the Cardiac Care Unit. Oxygen was administered by face mask and the electrocardiographic monitor showed atrial fibrillation, followed in rapid sequence by supraventricular tachycardia, ventricular tachycardia, and ventricular fibrillation. Defibrillation was promptly attempted with the use of a 400 w-sec discharge delivered via paddles applied to the anterior chest wall. When the first defibrillator discharge did not succeed in restoring a satisfactory rhythm, an intravenous injection of lidocaine, 100 mg, was given and a second 400 w-sec defibrillator discharge was delivered in similar fashion. There was a spark from one
Pulmonary Disease and Hair-Spray Polymers: A Disputed Relationship
Authors: Matthew J. Brunner
Journal: JAMA (1963)

Massive exposure of experimental animals to a vinylalkylether/maleic ester copolymer hair spray by inhalation did not produce granulomatous disease as described in alleged human cases. Intratracheal instillation of hair-spray solids also failed to reproduce the syndrome. In alleged cases of hair-spray thesaurosis, the connecting link was the presence of intracytoplasmic granules stained by the periodic acid-Schiff method and said to be particles of hair-spray resin. However, similar granules were found in a number of diverse pulmonary disorders in patients who had not been exposed to hair sprays, and the general staining characteristics of several hair-spray polymers did not correspond with those of the granules found in claimed instances of thesaurosis.
Intraperitoneal hydrocortisone in eosinophilic peritonitis associated with continuous ambulatory peritoneal dialysis.
Authors: A C Leung, G Orange, I S Henderson
Journal: BMJ (1983)

The recommended first aid is to remove powder from the mouth, give water or milk, observe for foam inhalation, and do not give acid substances.The manufacturers state that they know of no previous cases despite the global distribution of this product.I thank the Aboriginal health workers and Sister Rachel Jordan for their help, and J Hole, Lever and Kitchen, Sydney, for the technical information.
Cardiovascular Reactivity in Adolescent Boys of Low Socioeconomic Status Previously Characterized as Anxious, Disruptive, Anxious-Disruptive or Normal during Childhood
Authors: Patricia L. Dobkin, Frank A. Treiber, Richard E. Tremblay
Journal: Psychotherapy and Psychosomatics (1999)

&lt;i&gt;Background:&lt;/i&gt; The purpose of the study was to compare cardiovascular reactivity, a potential mechanism underlying the development of cardiovascular disease (CVD), in boys with different behavioral characteristics. &lt;i&gt;Method:&lt;/i&gt; Eighty-nine adolescent boys with low socioeconomic status who were classified as anxious, disruptive, anxious-disruptive or boys without these characteristics (i.e. control) during childhood were observed during a laboratory stress experiment. &lt;i&gt;Result:&lt;/i&gt; No significant group differences were found for resting levels of diastolic or systolic blood pressure (SBP). Anxious and anxious-disruptive boys exhibited greater SBP reactivity to the social stressor (Social Competence Interview) compared to the disruptive and control boys. The disruptive boys tended to engage in compromising behaviors which are associated with health problems. The anxious boys were significantly more likely to have a positive family history of hypertension. &lt;i&gt;Conclusions:&lt;/i&gt; Boys with different behavioral problems (anxiety, disruptiveness) may be at risk for CVD via different mechanisms.
Cardiovascular Disease and Dialysis
Authors: THOMAS P. GIBSON
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 February 1975Cardiovascular Disease and DialysisTHOMAS P. GIBSON, M.D., WILLIAM A. BRIGGS, M.D., F.A.C.P., BETTY BOONE, PH.D.THOMAS P. GIBSON, M.D.Search for more papers by this author, WILLIAM A. BRIGGS, M.D., F.A.C.P.Search for more papers by this author, BETTY BOONE, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-2-283_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the editorial note by Friedman and Rosen (1) concerning the accelerated degenerative cardiovascular disease associated with long-term maintenance hemodialysis, the authors state that "intensive efforts are required to delineate all reasons" for this complication. We would like to introduce for consideration a factor common to every patient on hemodialysis, the extracorporeal circuit.The use of plastic tubing in hemodialysis as presently performed is indispensable. Di-2-ethylhexyl phthalate (DEHP) is the plasticizer most commonly used in the manufacture of hemodialysis tubing. Movement of DEHP into stored blood from polyvinyl chloride plastic bags and the delivery of DEHP to...References1. FRIEDMAN S and ROSEN H: Uremia and cardiovascular mortality. Ann Intern Med 81:696-697, 1974 LinkGoogle Scholar2. JAEGER R and RUBIN R: Migration of a phthalate ester plasticizer from polyvinyl chloride blood bags into stored human blood and its localization in human tissues. N Engl J Med 287:1114-1118, 1972 CrossrefMedlineGoogle Scholar3. RUBIN R and JAEGER R: Some pharmacologic and toxicologic effects of di-2-ethylhexyl phthalate (DEHP) and other plasticizers. Environ Health Perspect 3:53-60, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS P. GIBSON, M.D.; WILLIAM A. BRIGGS, M.D., F.A.C.P.; BETTY BOONE, PH.D.Affiliations: Department of Nephrology Division of Biochemistry Walter Reed Army Institute of Research Washington, D. C. 20012 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1975Volume 82, Issue 2Page: 283-283KeywordsBloodCardiovascular diseasesChloridesMedical dialysis ePublished: 1 December 2008 Issue Published: 1 February 1975 PDF downloadLoading ...
The Cancer Connection: And What We Can Do About It
Authors: Hugh H. Hussey
Journal: JAMA (1977)

Agran, a 32-year-old lawyer, found inspiration for<i>The Cancer Connection</i>from three thoughts: (1) The United States population is experiencing a raging cancer epidemic for which the author uses the rather contrived term "a cancer pox." (2) Despite the expenditure of huge sums for research, a cure for malignant neoplasia is unlikely in the foreseeable future. (3) Since the epidemic is "man-made," it can be checked by preventive measures. The book seeks to excite reader interest by a series of grisly case reports about cancer victims, and the reports in turn engender indictments of industries because they have exposed workers directly and populations indirectly to carcinogenic pollutants. The federal government and tobacco manufacturers are linked for blame; they have connived to cause lung cancer. The food industry is guilty of using unnecessary carcinogenic additives. Physicians and dentists have caused cancer by misuse and overuse of x-ray examinations. (Agran neglects to
The Ethics of Animal and Human Experimentation
Authors: F. Barbara Orlans
Journal: JAMA (1995)

The title of this book suggests that there will be ethical discussion of both animal and human experimentation. This expectation is only half fulfilled. Much of the discussion of human experimentation is informative, but the discussion of animal experimentation does not begin to address the most serious ethical issues. The book comprises 29 essays by more than 30 persons of various nationalities, mainly Belgian, Dutch, and American. Topics range over general reflections about the conduct of biomedical science, legislative controls, ethical problems of randomized clinical trials, and special cases of particularly vulnerable human groups such as the mentally disabled. The book's major strength lies in the breadth of thoughtful essays written by clinicians who are grappling with dilemmas in their own day-to-day experiences of conducting research on human subjects in combination with their therapeutic mission. The book provides insight into the moral problems that clinician-researchers face every day in balancing
Synthesis of a novel cytokine and its gene (LD78) expressions in hematopoietic fresh tumor cells and cell lines.
Authors: Y Yamamura, T Hattori, K Obaru, K Sakai, N Asou, K Takatsuki, Y Ohmoto, H Nomiyama, K Shimada
Journal: Journal of Clinical Investigation (1989)

The gene coding for the protein LD78 was isolated from stimulated human tonsillar lymphocytes by differential hybridization. The gene product consisted of 92 amino acids with characteristics of cytokines. LD78 gene transcripts were detected in eight of eight fresh samples of cells from patients with acute nonlymphocytic leukemia (ANLL) by Northern blot analysis. ANLL cells with monocytic features gave the strongest bands. RNA transcripts were found in two of three samples of cells from patients with adult T cell leukemia (ATL), eight of nine samples from patients with acute lymphocytic leukemia (ALL) of B cell lineage, and one of the three samples from patients with T cell ALL. KG-1, HL-60, HUT 102, MT-2, and MJ cell lines expressed the LD78 gene constitutively. The LD78 protein was detected in culture supernatants and cell lysates of HUT 102, MT-2, MJ, and fresh ATL cells by Western blot analysis. This protein was not found in culture supernatants or cell lysates of monocytic leukemia cells and HL-60 cells, although LD78 transcripts were found in those cells. The discrepancy between gene and protein expression might be explained by the stability of the mRNA. Thus, the protein may be involved in the neoplastic transformation of hematopoietic cells.
Blood flow pattern of the interatrial communication in patients with complete transposition of the great arteries: a pulsed Doppler echocardiographic study.
Authors: G Satomi, M Nakazawa, A Takao, K Mori, K Touyama, T Konishi, H Tomimatsu, K Nakamura
Journal: Circulation (1986)

We analyzed blood flow pattern in the interatrial communication in 24 patients with complete transposition of the great arteries (TGA). Eight had TGA with atrial shunt (group 1), nine had TGA with patent ductus arteriosus or ventricular septal defect (group 2), and seven had pulmonary arterial banding and Blalock-Taussig shunt (group 3). The flow pattern was determined at the site of atrial septal defect by Doppler echo beam directed as perpendicular to the septum as possible. The flow pattern was composed of a left-to-right (L-R) flow and right-to-left (R-L) flow. The turning point (T1) from the R-L to L-R flow occurred immediately after the initiation of the QRS on the electrocardiogram and was common in all groups. The other turning point (T2) from L-R to R-L occurred after the second heart sound (S2). The S2-T2 interval decreased on inspiration, indicating prolongation of the period of R-L flow. The minimum S2-T2 interval ranged from 20 to 70 (mean +/- SD 50 +/- 18) msec in group 1, from 70 to 130 (114 +/- 25) msec in group 2, and from 50 to 138 (75 +/- 29) msec in group 3. The maximum S2-T2 interval ranged from 48 to 110 (88 +/- 21) msec in group 1, from 140 to 235 (175 +/- 36) msec in group 2, and from 80 to 170 (111 +/- 30) msec in group 3.(ABSTRACT TRUNCATED AT 250 WORDS)
Are there universals of reading? We don't believe so
Authors: Max Coltheart, Stephen Crain
Journal: Behavioral and Brain Sciences (2012)

Abstract There are universals of language; but is it also true, as the target article claims, that there are universals of reading? We believe there are no such universals, and invite others to refute our claim by providing a list of some universals of reading. If there are no universals of reading, there cannot be a universal model of reading.
Italian court upholds couple's demand for preimplantation genetic diagnosis
Authors: Fabio Turone
Journal: BMJ (2007)

The battle on assisted reproduction and prenatal diagnosis in Italy took a new turn last week, when the gynaecologist Giovanni Monni, head of the obstetrics and gynaecology department in the Ospedale Microcitemico in Cagliari, Sardinia, was ordered by the local court to provide preimplantation genetic testing to a couple carrying the gene for β thalassaemia, which is common on the island.

Dr Monni, the current president of the Italian Association of Hospital Gynaecologists, had unwillingly obeyed the controversial law approved in 2004, which, through guidelines, forbids preimplantation genetic diagnosis, even though he personally supported the couple's request for it ( BMJ 2004;328:9, doi: 10.1136/bmj.328.7430.9). “I am very glad of the court's decision,” he told the BMJ .

The law contains several …
Incubation as a Form of Psychotherapy in the Care of Patients in Ancient and Modern Greece
Authors: M.G. Papageorgiou
Journal: Psychotherapy and Psychosomatics (1975)

Incubation or temple sleep in sanctuaries of Aesculapius, Amphiaraos, Trophonios, etc., for the care of patients was practised even in the older times of ancient Greece and may be viewed as a form of psychotherapy and especially as 'dream-psychotherapy'. In Greek antiquity, as it is known, dreams were considered as a way of communication between gods and men. Survival of the custom of incubation exists even in our times in modern Greece, but are disappearing slowly. An attempt is made to find an explanation, if any, of those miraculous cures in accordance with the scientific thought of today.
First loyalty was to his patients, former BMA chairman tells GMC
Authors: C. Dyer
Journal: BMJ (2010)

Jim Johnson, the BMA’s previous chairman, denied putting the representation of doctors before his duties to his patients as he gave evidence in his defence at a General Medical Council hearing in Manchester.

A former consultant surgeon at Halton and Warrington hospitals in Cheshire, he faces charges of misconduct and deficient professional performance involving 14 patients, including performing unnecessary operations, failing to obtain informed consent, failing to involve himself in patients’ postoperative care, and being rude to colleagues ( BMJ 2010;341:c5883, doi:10.1136/bmj.c5883).

The GMC alleges that patients missed out while he juggled the …
Interaction of the legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes but does not inhibit intracellular multiplication.
Authors: M A Horwitz, S C Silverstein
Journal: The Journal of Experimental Medicine (1981)

In an accompanying paper (13), we reported that human polymorphonuclear leukocytes kill only a limited proportion (0.5 log) of an inoculum of Legionella pneumophila (Philadelphia 1 strain) in the presence of human anti-L. pneumophila antibody and complement. We now report on the effect of anti-L. pneumophila antibody on L. pneumophila-monocyte interaction. The studies were carried out under antibiotic-free conditions. Monocytes bind more than three times as many viable L. pneumophila bacteria in the presence of both antibody and complement than in the presence of complement alone. Monocytes requires both antibody and complement to kill any L. pneumophila: however, even then, monocytes kill only a limited proportion (0.25 log) of an inoculum. The surviving bacteria multiply several logs in the monocytes and multiply as rapidly as when the bacteria enter monocytes in the absence of antibody. These findings suggest that humoral immunity may not be an effective host defense against L. pneumophila. Consequently, a vaccine that resulted only in antibody production against the Legionnaires' disease bacterium may not be efficacious.
Randomized trial of asunaprevir plus peginterferon alfa and ribavirin for previously untreated genotype 1 or 4 chronic hepatitis C
Authors: Jean-Pierre Bronowicki, Vlad Ratziu, Adrian Gadano, Paul J. Thuluvath, Fernando Bessone, Claudia T. Martorell, Stanislas Pol, Ruben Terg, Ziad Younes, Bing He, Timothy Eley, David Cohen, Fei Yu, Dennis Hernandez, Fiona McPhee, Patricia Mendez, Eric Hughes
Journal: Journal of Hepatology (2014)
A RISK SCORE TO PREDICT MAJOR ADVERSE EVENTS AND 30-DAY ALL-CAUSE MORTALITY IN PATIENTS UNDERGOING TRANSVENOUS LEAD EXTRACTION.
Authors: Michael P. Brunner, Changhong Yu, Rory Hachamovitch, Valeria Duarte, Edmond M. Cronin, Bryan Baranowski, Khaldoun G. Tarakji, Daniel J. Cantillon, David O. Martin, Oussama Wazni, Bruce L. Wilkoff
Journal: Journal of the American College of Cardiology (2013)
Picasso's Roots-Reply
Authors: Fred Butzen
Journal: JAMA (1987)

In Reply.—  Indeed, Picasso was born in Malaga, but spent his formative adolescent years in Barcelona, where he participated very actively in Catalonion intellectual and political life, and it was to Barcelona that he returned on family visits. Several sources state that he did speak Catalan fluently. For an extensive discussion of his involvement in Catalonion intellectual life, see Palau i Fabrej: Picasso: The Early Years, 1881-1907 , Lyons K (trans). Barcelona, Ediciones Poligrafa SA, 1985.
Experts Hope to Clear Confusion With First Guidelines to Tackle Food Allergy
Authors: Rebecca Voelker
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
D-penicillamine and immune complex deposition.
Authors: J D Kirby, P A Dieppe, E C Huskisson, B Smith
Journal: Annals of the Rheumatic Diseases (1979)

Dense, granular immunoglobulin deposits have been identified at the epidermo-dermal junction in 4 out of 10 patients who developed toxic reactions to D-penicillamine therapy for rheumatoid arthritis. Three of 4 patients developing a lupus-like syndrome while on penicillamine had similar findings on skin biopsy. Serum immunoglobulin and complement levels decreased significantly in patients treated with penicillamine. It is suggested that, in addition to penicillamine nephropathy, other side effects of this drug may be related to widespread deposition of immune complexes.