tbuckley/cabot-search huggingface dataset:
Diabetes and impotence
Authors: R. B. Chadband
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recognition of Partial Defects in Antidiuretic Hormone Secretion
Authors: MYRON MILLER
Journal: Annals of Internal Medicine (1970)

A dehydration procedure has been used to identify patients with partial antidiuretic hormone (ADH) deficiency. The test consists of water deprivation until the osmolality of hourly voided urines reaches a plateau and then relating the urine osmolality at which this occurs to the osmolality recorded after subsequent injection of ADH. In patients with normal neurohypophysial function and patients with primary polydipsia, urine osmolality at the end of such a period of deprivation was much greater than plasma osmolality and did not increase more than 5% after the injection of 5 units of aqueous vasopressin. In patients with severe ADH deficiency urine osmolality before ADH was much less than plasma osmolality; after ADH injection, however, it was increased by more than 50%. Thirteen patients in whom urine osmolality was greater than plasma osmolality after water deprivation and was further increased by 9% to 67% after ADH injection were considered to have partial ADH deficiency. Some patients with ADH deficiency apparently exhausted their limited neurohypophysial ADH stores during prolonged dehydration, with resultant change from partial to severe hormone deficiency.
A study of large congenital melanocytic nevi and associated malignant melanomas: Review of cases in the New York University registry and the world literature
Authors: Maria DeDavid, Seth J. Orlow, Nathalie Provost, Ashfaq A. Marghoob, Babar K. Rao, Carol L. Huang, Qasim Wasti, Alfred W. Kopf, Robert S. Bart
Journal: Journal of the American Academy of Dermatology (1997)

Background: Patients with large congenital melanocytic nevi (LCM]V) are at greater risk for the development of malignant melanoma (MM) than are persons in the general population.Objective: Our purpose was to identify the clinical features of LCMN in those patients in whom MMs actually developed.Methods: The records of 117 patients in the New York University Registry of LCMN and the reports of 172 cases of LCMN in the world literature were studied.Results: Of the 289 cases of LCMN studied, 34 patients (12%) had primary cutaneous MMs within their nevi; in two additional patients, MMs developed at cutaneous sites other than within their nevi.All patients in whom MM developed within LCMN had nevi in axial locations; however, 91% of the LCMN were axial.No MM was found that had arisen in any of the 26 LCMN confined to the extremities.In addition, no MM was found that had arisen in thousands of satellite nevi. Conclusion:When MM develops within an LCMN, it generally does so in those LCMN in an axial location.The absence of cases of MM arising in LCMN confined to the extremities suggests that such nevi represent lower risk lesions, but the ntunber of extremity nevi analyzed was too small to allow definitive conclusions.A striking finding was the absence of MMs arising in satellite nevi.
Number of strictures predictive of recurrent surgical intervention in a paediatric population with obstructive crohn's disease
Authors: R. Bamford, A. Hay, D. Kumar
Journal: Gut (2011)

<h3>Introduction</h3> 70–90% of Crohn9s patients will require surgery with younger patients often requiring further procedures. Our aim was to investigate whether the number of strictures at the time of surgery can be used to predict the need for further surgical intervention. <h3>Methods</h3> Patients under 20 years of age undergoing surgery between 1 January 2000 and 1 June 2009 were identified. Data was collected on procedures for stenotic Crohn9s disease, including previous surgery outside the original inclusion dates. Therefore operations between 12 December 1996 and 16 February 2009 are represented. Patients were divided into two groups; group 1 with less than 4 strictures and group 2 with 4 or more strictures. Recurrence was defined as the need for further surgical intervention and Kaplan Meir method was used to analyse the data. <h3>Results</h3> 26 patients and 40 operations were identified. Mean age was 15.57 years (7.2–19.4) with equal numbers of males and females. 19 operations were strictureplasties, 13 were resections and 8 were combined procedures. Mean follow-up was 67.44 months (10.5–156.6). 20/40 (50%) procedures involved the terminal ileum, 9/40 (22.5%) the ileo-colic junction, 8/40 (20%) the upper GI tract and 3/40 (7.5%) the colon. Group 1 consisted of 29/40 (72.5%) procedures and group 2 11/40 (27.5%). Recurrence rate for all operations was 35% (14/40). Patients in group 1 had significantly less recurrence than group 2 (24% vs 63.6%, p=0.033). <h3>Conclusion</h3> Children and adolescents with 4 or more strictures at the time of surgery are likely to require further surgical intervention and should be counselled and managed as such.
High intestinal lactase concentrations in adult Arbs in Saudi Arabia.
Authors: G C Cook, M T al-Torki
Journal: BMJ (1975)

The maximum rise in blood glucose after 50 g lactose by mouth was determined in 40 adult Arabs. Out of 30 Bedouin, urban Saudi, and Yemeni and 9 of mixed ancestry (usually partly African), 25 (83%) and 2 (22%) respectively showed an increase of over 1-1 mmol/1 (20 mg/100 ml). In common with most northern Europeans and Hamitic people of northern Africa, Arabs in Saudi Arabia usually have high intestinal lactase concentrations in adult life. This persistence of high levels probably originated in the Arabian peninsula. Its selective advantage may have been associated with the fluid and calorie content of camels' milk, which is important for survival in desert nomads.
MALARIA A WATERBORNE DISEASE—AN OLD IDEA.
Authors: J. F. Jenkins
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Removal technique for grapefruit-sized BioEnterics intragastric balloon
Authors: J. Gonzalez, J. Barkin
Journal: Endoscopy (2006)

Gastric balloons were quickly adopted as a method of treating obesity. The most widely used system features a saline-filled silicone balloon [1] [2]. However, gastroenterologists are sometimes unfamiliar with methods of removing these endoscopically placed gastric balloons [3].
CHANGES IN OUTLYING BONE MARROW ACCOMPANYING A LOCAL INCREASE OF TEMPERATURE WITHIN PHYSIOLOGICAL LIMITS
Authors: Charles Huggins, B. H. Blocksom
Journal: The Journal of Experimental Medicine (1936)

A great difference exists in the adult bone marrow of central bones as compared with outlying bones of the mammalia and avia, the distal bones being at a great disadvantage from the standpoint of blood cell production. Several experimental procedures are reported by which this disadvantage is overcome and in consequence fatty marrow of outlying bones is replaced by red marrow occurring chiefly at the epiphyseal regions, unless a low oxygen stimulus is also provided when marrow of the diaphysis becomes involved. A common factor in all of the experiments was an elevation of temperature beyond that prevailing in these distal regions, and it is felt that the evidence warrants the opinion that the cause of improvement is thermal. In some experiments, blood cell formation was increasing while the heat was adversely affecting the testis. The experiments permit construction of a general theory of fat distribution in bone marrow. In certain grafts of precartilage to other rats, normal differentiation into bone, cartilage, and marrow occurred, while in others cartilage and very small amounts of primitive marrow developed with slight, or no bone formation. Cartilage was always successfully engrafted. The capacity to form sinusoids in bone marrow is determined by the nature of the tissue rather than by the ingrowing endothelium.
Variation in the tumour necrosis factor- gene is not associated with susceptibility to Asian COPD
Authors: S. Teramoto, T. Ishii, M. Ishii, H. Yamamoto, Y. Yamaguchi, S. Hibi, Y. Ouchi
Journal: European Respiratory Journal (2008)

To the Editors: 

In a recent issue of the European Respiratory Journal , Chappell et al. 1 clearly demonstrated that the lack of association with any of the tumour necrosis factor (TNF)-α single nucleotide polymorphisms or haplotypes makes it highly unlikely that polymorphisms in this gene play a major role in susceptibility to chronic obstructive pulmonary disease (COPD).

Their sample sizes were sufficient to elucidate association of TNF-α gene variations with susceptibility to COPD. However, they neglected the effect of ethnicity differences in genetic susceptibility to COPD. The frequency of the TNF-α-308*2 allele in Caucasian control populations (10–17%) is higher than that in Asians (0–8%) 1–10.

Genetic susceptibility …
Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy
Authors: Joaquin Palma, Humberto Reyes, Jose Ribalta, Joaquin Iglesias, Manuel C. Gonazalez, Ismael Hernandez, Celia Alvarez, Claudina Molina, Ana Maria Danitz
Journal: Hepatology (1992)

The efficacy and safety of ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy was investigated in an open pilot study. Five patients received 1 gm/day of ursodeoxycholic acid during 20 days and another three patients received two identical periods of treatment separated by a 14–day interval free of the drug. Pruritus and serum levels of total bile salts and glutamic–pyruvic transaminase improved significantly during treatment with ursodeoxycholic acid. In the three patients who received two periods of treatment with ursodeoxycholic acid, pruritus and the laboratory alterations relapsed in the second week after the drug was discontinued, but they improved again when ursodeoxycholic acid was readministered. No adverse reactions were detected in the mothers or in their babies. All newborns were thriving normally during a follow–up period that lasted 5 mo after delivery. It is concluded that UDCA appears to be safe when administered in late pregnancy; its promising efficacy in the treatment of intrahepatic cholestasis of pregnancy should now be confirmed in controlled clinical trials. (Hepatology 1992;15:1043-1047).
Opioids for back pain are linked to increased risk of erectile dysfunction
Authors: S. Ramsey
Journal: BMJ (2013)

Men who take opioid analgesics for back pain over a long period may have an increased risk of erectile dysfunction, a study has found.1Long term opioid use has already been linked with hypogonadism.

To explore the relation between the use of drugs for erectile dysfunction or testosterone replacement and opioid use, researchers looked 11 327 men diagnosed with back pain on at least one visit in 2004. Their mean age was 49 years. The researchers …
SOME EFFECTS OF ANTERIOR PITUITARY EXTRACTS ON NITROGEN METABOLISM, WATER BALANCE, AND ENERGY METABOLISM
Authors: Oliver H. Gaebler
Journal: The Journal of Experimental Medicine (1933)

1. Solutions of the globulin fraction of alkaline extracts of the anterior lobe of beef pituitary glands, when administered intraperitoneally or subcutaneously to dogs for 1 or 2 days, greatly increase the nitrogen balance. Urine nitrogen falls markedly, and at the same time blood non-protein nitrogen decreases, while the nitrogen of the feces remains the same. 2. The nitrogen gained may either be retained or lost again, indicating that it may be converted into reserve protein rather than into permanent structures. Sudden gains in weight which follow the injections are always lost again. 3. The effect of the extracts on protein catabolism is greatest when this is high, as in adult dogs having a negligible positive nitrogen balance, or a negative balance, while consuming a high protein diet adequate in calories. 4. Both the fall in nitrogen excretion, and the subsequent rise, when the latter occurs, are due to changes in urea excretion. 5. Other results of the brief treatments are: great increases in water intake and urine volume, marked thirst, slight rise in temperature, and a remarkable increase in heat production effected by oxidation of fat. Mature female dogs were used, and in one of these lactation occurred after some of the injections.
Inhalation of prostacyclin (PGI2) for 8 hours does not produce signs of acute pulmonary toxicity in healty lambs
Authors: O. Habler, M. Kleen, B. Zwissler, R. Pusch, M. Welte, C. Vogelmeier, B. Kempter, F. Krombach, K. Messmer
Journal: Intensive Care Medicine (1996)
Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction.
Authors: Y A Sidky, R Auerbach
Journal: The Journal of Experimental Medicine (1975)

A new and sensitive assay for the effect of intracutanous administration of immunocompentent lymphocytes into the skin of irradiated unimmunized mice is described. The assay, which we have termed lymphocyte-induced angiogenesis (LIA) involves enumeration of new vascular branches induced by the action of these competent cells. As is the case for the previously described normal lymphocyte transfer reaction, LIA is a manifestation of the graft-vs.-host reaction, as shown by experiments utilizing appropaiate genetic combinations. The reaction is dose-dependent, and within the dose range of 2 times 10 minus 5 -4 times 10-6 cells the mumber of vessels induced correlates with the mumber of immunocompetent cells injected. At these dose levels spleen, lumph node, and hydrocortisone-resistant thymocytes are effective; bone marrow and thymus cells are not. Spleen cells from nude mice are incapable of inducing LIA, while mitomycin-C and irradiated lymphocytes can initiate but not maintain the reaction. The relationship between lymphocyte-induced angiogenesis has been discussed as have the implications of these findings to delayed hypersensitivity, inflammation, and vascular pathology.
SIGMOID SURGERY FROM THE INTRA-ABDOMINAL AND INTRAPELVIC STANDPOINT.
Authors: J. G. CARPENTER
Journal: JAMA (1898)

Diseases of the sigmoid have remained in practical obscurity, and the sigmoid per se, so far as the rectal specialist and general surgeon are concerned, have been a terra incognita. November, 1885, the sigmoid cavity was first exposed with the light of research, and scientific truths observed in the living subject narrated and made a part of historic discovery by the writer. The pathologist only knew diseases of the sigmoid as concerns malignant growths or benign neoplasms, or a possible sigmoid stricture, ulceration or fecal impaction, and what is now shown by Carpenter's sigmoidoscopy as a sigmoiditis with or without ulceration, was in the recent past supposed to be a proctitis or a colitis, the pathologist only dealing with diseases of the sigmoid as a postmortem observation. Now, with sigmoidoscopy (Carpenter's) we are also able to not only explore the rectum in its entirety, illumine the sigmoid cavity, and with
Bile Concentration Is A Key Factor for Nucleation of Cholesterol Crystals and Cholesterol Saturation Index in Gallbladder Bile of Gallstone Patients
Authors: Karel J. Van Erpecum, Gerard P. Berge Van Henegouwen, Bregt Stoelwinder, Yvonne M.G. Schmidt, Frans L.H. Willekens
Journal: Hepatology (1990)

We investigated whether bile concentration influenced cholesterol saturation index or nucleation time of cholesterol monohydrate crystals in a large number of gallbladder bile samples. Pigment stone patients never had cholesterol crystals in their fresh biles, and nucleation time was always longer than 20 days. Of the cholesterol stone patients 79% had cholesterol crystals in their fresh biles. Long nucleation times were generally found in cholesterol stone patients with dilute biles despite a high cholesterol saturation index. Nucleation time was usually short if bile was well concentrated depite a relatively low saturation index. Serial in vitro dilution of concentrated biles from cholesterol gallstone patients resulted in progressively prolonged nucleation times. Patients with solitary cholesterol stones had longer nucleation times than patients with multiple cholesterol stones. This study indicates that bile concentration is an important factor for nucleation time and cholesterol saturation index. Moreover, solitary and multiple cholesterol stones may have a different pathogenesis. (HEPATOLOGY 1990; 11: 1-6.)
Oral Acyclovir to Suppress Recurring Herpes Simplex Virus Infections in Immunodeficient Patients
Authors: STEPHEN E. STRAUS
Journal: Annals of Internal Medicine (1984)

Thirty-two episodes of herpes simplex virus infection in four immunodeficient patients with frequent recurrences were successfully treated with oral acyclovir, one capsule five times a day for 5 days. In 23 of these episodes, the treatments were extended for 1 to 6 months using two to five capsules a day with the aim of suppressing expected recurrences. In these patients, who routinely had more than one recurrence per month before treatment, there were only six outbreaks during more than 60 patient-months of suppressive therapy. Infection always recurred after treatments were completed, but the time to recurrence was shorter after treatments with two acyclovir capsules per day than after treatments with five capsules per day (p < 0.001).
OTITIS MEDIA, WITH TRIPLE PERSONALITY.
Authors: A. J. ERWIN
Journal: JAMA (1899)

It is not the purpose of this paper to enter upon a critical discussion of otitis media, any further than seems necessary to properly bring before you the history of an unusually interesting case, which has been under my care for the last few months. Purulent otitis media may be idiopathic, or secondary to catarrhal otitis, or to an attack of the exanthematous fevers, notably scarlet fever or measles. It consists of an acute inflammation of the lining membranes of the tympanum, which may extend to the mastoid cells, and to the eustachian tube, attended by severe pain, fever, and more or less swelling of the external auditory canal and its environments, with early spontaneous perforation of the drum-head, unless previously punctured. After the free escape of the pus, the pain, swelling and fever subside; under favorable conditions and treatment, the discharge ceases within a fortnight—it may stop in a
A piece of my mind. The person with the disease
Authors: C. K. Meador
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BikDD Eliminates Breast Cancer Initiating Cells and Synergizes with Lapatinib for Breast Cancer Treatment
Authors: Jing-Yu Lang, Jennifer L. Hsu, Funda Meric-Bernstam, Chun-Ju Chang, Qingfei Wang, Yi Bao, Hirohito Yamaguchi, Xiaoming Xie, Wendy A. Woodward, Dihua Yu, Gabriel N. Hortobagyi, Mien-Chie Hung
Journal: Cancer Cell (2011)
Wheat lipid transfer protein is a major allergen associated with baker's asthma
Authors: Arantxa Palacin, Santiago Quirce, Alicia Armentia, Mar Fernández-Nieto, Luis F. Pacios, Teresa Asensio, Joaquin Sastre, Araceli Diaz-Perales, Gabriel Salcedo
Journal: Journal of Allergy and Clinical Immunology (2007)
Construct Validity of the Toronto Alexithymia Scale
Authors: Michael Bagby, Graeme J. Taylor, James D.A. Parker
Journal: Psychotherapy and Psychosomatics (1988)

Previous reports have documented the development of the Toronto Alexithymia Scale (TAS) in addition to evaluating its reliability and validity. The present paper describes two studies designed to further evaluate the construct validity of the TAS. In Study 1117 university students completed the TAS and the three subscales of the Short Imaginal Processes Inventory. In Study II 74 students completed the TAS and measures of ego strength, anger expression, and physical symptoms. In both studies the pattern of correlations between the TAS and the various psychological measures converged and diverged in a theoretically meaningful fashion, providing further evidence for the validity of the TAS and of the alexithymia construct.