tbuckley/cabot-search huggingface dataset:
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants
Authors: Thorbald van Hall, Elisabeth Z Wolpert, Peter van Veelen, Sandra Laban, Michael van der Veer, Marjet Roseboom, Sandra Bres, Per Grufman, Arnoud de Ru, Hugo Meiring, Ad de Jong, Kees Franken, Antoinette Teixeira, Rob Valentijn, Jan Wouter Drijfhout, Frits Koning, Marcel Camps, Ferry Ossendorp, Klas Kärre, Hans-Gustaf Ljunggren, Cornelis J M Melief, Rienk Offringa
Journal: Nature Medicine (2006)
THERAPEUTIC EFFECT OF TOTAL ABLATION OF NORMAL THYROID ON CONGESTIVE HEART FAILURE AND ANGINA PECTORIS. IX. POSTOPERATIVE PARATHYROID FUNCTION. CLINICAL OBSERVATIONS AND SERUM CALCIUM AND PHOSPHORUS STUDIES1
Authors: D. R. Gilligan, D. D. Berlin, M. C. Volk, B. Stern, H. L. Blumgart
Journal: Journal of Clinical Investigation (1934)
Effect of ozone on respiratory responses in subjects with asthma.
Authors: J Q Koenig
Journal: Environmental Health Perspectives (1995)

In the process of understanding the respiratory effects of individual air pollutants, it is useful to consider which populations seem to be most susceptible to the exposures. Ozone is the most ubiquitous air pollutant in the United States, and there is great interest in the extent of susceptibility to this air pollutant. This review presents evidence that individuals with asthma are more susceptible to adverse respiratory effects from ozone exposure than are nonasthmatic individuals under similar circumstances. In studies comparing patients with asthma to nonasthmatic subjects, research has shown increased pulmonary-function decrements, an increased frequency of bronchial hyperresponsiveness in ozone responders, increased signs of upper airway inflammation after ozone exposure, and an increased response to inhaled sulfur dioxide or allergen in the subjects with asthma. Subjects with asthma are indeed a population susceptible to the inhaled effects of ozone. These data need to be considered by regulators who are charged with setting air quality standards to protect even the most susceptible members of the population. They also underline the importance of strategies to reduce human exposure to ambient ozone.
Acquired Gefitinib-Resistant Mutation of EGFR in a Chemonaive Lung Adenocarcinoma Harboring Gefitinib-Sensitive Mutation L858R
Authors: Chien-Hung Gow, Jin-Yuan Shih, Yih-Leong Chang, Chong-Jen Yu
Journal: PLoS Medicine (2005)

Covering 60 years of research without mentioning a paper that highlights fl aws in the literature, in a review, should negate any conclusion.In the Cochrane review by Douglas et al. [1], which is referenced in the Best Practice article by Douglas and Hemilä [2], there was no mention of the revealing paper published last year by Padayatty et al. [3], which shows that three-times greater blood concentration can be achieved with an oral dose of vitamin C than previously thought possible.Since viruses increase the demand for ascorbic acid, the oral doses used in the reviewed studies appear trivial, and would not be expected to produce any positive effect.Compare human oral dose studies to what animals synthesize throughout the day.It is obvious that a single dose of a watersoluble vitamin, regardless of the number of milligrams consumed, will not elevate blood plasma levels enough to produce a preventive or therapeutic effect.
Bone Density and Vitamin D Intoxication
Authors: Malachi J. McKenna
Journal: Annals of Internal Medicine (1998)

Letters15 March 1998Bone Density and Vitamin D IntoxicationMalachi J. McKenna, MD and Rosemarie Freaney, PhDMalachi J. McKenna, MDSt. Vincent's Hospital; Dublin 4, Ireland and Rosemarie Freaney, PhDSt. Vincent's Hospital; Dublin 4, IrelandAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-6-199803150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hypovitaminosis D in the elderly is a worldwide problem [1]. No evidence suggests that supplementation with parent vitamin D (either low-dose continuous or high-dose intermittent therapy) in the elderly is dangerous [2], but high doses taken over long periods predispose recipients to hypercalcemia. Even community-dwelling elderly persons benefit from daily administration of calcium (500 mg) and vitamin D (700 IU) [3]. Adams and Lee [4] report four cases of hypervitaminosis D due to vitamin D intake from multivitamin and dietary supplements. No effort is made to provide even an estimate of vitamin D intake. This is unacceptable ...References1. McKenna MJ. Differences of vitamin D status between various countries in young adults and the elderly. Am J Med. 1992; 93:69-77. Google Scholar2. Byrne P, Freaney R, McKenna MJ. Vitamin D supplementation in the elderly: safety and effectiveness of various regimes. Calcif Tissue Int. 1995; 56:518-20. Google Scholar3. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age and older. N Engl J Med. 1997; 337:670-6. Google Scholar4. Adams JS, Lee G. Gains in bone mineral density with resolution of vitamin D intoxication. Ann Intern Med. 1997; 127:203-6. Google Scholar5. Marriott BM. Vitamin D supplementation: a word of caution [Editorial]. Ann Intern Med. 1997; 127:231-3. Google Scholar Author, Article, and Disclosure InformationAffiliations: St. Vincent's Hospital; Dublin 4, Ireland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVitamin D and respiratory infection in adultsVitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety 15 March 1998Volume 128, Issue 6Page: 507-508KeywordsBone densityCalciumElderlyEstrogensHypercalcemiaIntoxicationOsteopeniaOsteoporosisUrineVitamin D Issue Published: 15 March 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
(6) Incontinentia pigmenti achromians (hypomelanosis of Ito)
Authors: S.S. Bleehen, S.B. Bittiner, B.L. Priestley
Journal: British Journal of Dermatology (1986)

Journal Article (6) Incontinentia pigmenti achromians (hypomelanosis of Ito) Get access S.S. Bleehen, Drs, S.S. Bleehen, Drs Children's Hospital, Sheffield Search for other works by this author on: Oxford Academic Google Scholar S.B. Bittiner, S.B. Bittiner Children's Hospital, Sheffield Search for other works by this author on: Oxford Academic Google Scholar B.L. Priestley B.L. Priestley Children's Hospital, Sheffield Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s30, 1 July 1986, Pages 48–49, https://doi.org/10.1111/j.1365-2133.1986.tb07701.x Published: 01 July 1986
Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants
Authors: H. M. H. Spronk, A. M. de Jong, H. J. Crijns, U. Schotten, I. C. Van Gelder, H. ten Cate
Journal: Cardiovascular Research (2014)

Factor Xa and thrombin are well-known components of the coagulation cascade and have been proven to be viable targets for effective anticoagulation treatment. However, accumulating evidence suggests that these serine proteases are also crucial modulators of other cellular mechanisms through the activation of protease-activated receptor (PAR)-mediated signalling. The involvement of factor Xa, thrombin, and PARs in normal biological and pathophysiological processes has been recognized, and their potential implications have been explored in recent years. Both factor Xa and thrombin play significant roles in mediating cellular signalling effects associated with the initial development of atherosclerosis: a chronic inflammatory vascular disease. In addition, increased expression and activation of PARs may be associated with atrial fibrillation (AF) and AF-associated thromboembolism hypercoagulability. Both pathologies are associated with hypercoagulability, suggesting that the role of cellular effects of factor Xa and thrombin and of their specific inhibitors should be studied in relation to the prevention of thrombotic and pro-arrhythmic changes. This review examines the role of factor Xa-mediated and thrombin-mediated PAR activation in modulating cellular processes involved in atherosclerosis and AF and discusses the potential implication of direct factor Xa and thrombin inhibition on effects outside coagulation.
Risk of multiple primary malignancies following treatment of Hodgkin lymphoma
Authors: Anna M. van Eggermond, Michael Schaapveld, Pieternella J. Lugtenburg, Augustinus D. G. Krol, Jan Paul de Boer, Josée M. Zijlstra, John M. M. Raemaekers, Leontien C. M. Kremer, Judith M. Roesink, Marieke W. J. Louwman, Berthe M. P. Aleman, Flora E. van Leeuwen
Journal: Blood (2014)
Evidence for a Metabolic Mechanism in Autoregulation of Blood Flow in Skeletal Muscle
Authors: RICHARD D. JONES, ROBERT M. BERNE
Journal: Circulation Research (1965)

Simple criteria have been used in an isolated, perfused skeletal muscle preparation to determine whether autoregulation of blood flow in this tissue is the consequence of a metabolic or a myogenic mechanism. Elevation of venous pressure significantly decreased equilibrium vascular resistance and reduction of venous pressure significantly increased vascular resistance during controlled pressure perfusion whereas alteration of ambient pressure had no significant effect on equilibrium resistance. These responses repudiate a myogenic mechanism for autoregulation of equilibrium blood flow since the myogenic hypothesis predicts increased resistance following increased transluminal pressure and decreased resistance following decreased transluminal pressure. Moreover, during perfusion at constant blood flow, metabolic regulation should be constant and myogenic responses would be permitted full expression. Alteration of venous pressure or ambient pressure during constant flow perfusion, however, failed to evoke myogenic responses at equilibrium. Rather, a passive distention was observed at equilibrium after increased transmural pressure, and passive recoil of the vessels followed decreased transmural pressure during constant flow perfusion. All pressure alterations were accompanied by transient resistance changes of undetermined origin. With the criteria employed, however, the results indicate that the regulation of equilibrium vascular resistance in skeletal muscle is based primarily on a metabolic mechanism.
Abstract 893: Free Fatty Acids lead to Endothelial VEGF Resistance
Authors: Vishal C Mehra, Pascal Bernatchez, Gerald Shulman, William Sessa, Jeffrey Bender
Journal: Circulation (2007)

Elevation of free fatty acids (FFA) and their intermediates underlies abnormalities in insulin signaling observed in obesity, metabolic syndrome and type 2 diabetes mellitus, and has been associate...
Raised serum creatine phosphokinase activity in ankylosing spondylitis.
Authors: A Calin
Journal: Annals of the Rheumatic Diseases (1975)

Serum enzyme studies were made on 43 (37 male, 6 female) consecutive patients with ankylosing spondylitis. Serum creatine phosphokinase (CPK) activity was raised above 55 IU/l in 24 (65%) of 37 male patients (range 29-165 IU/l, mean 68) as compared with 2 (4%) out of 47 male controls (range 14-85 IU/l, mean 33: P less than 0-001); levels were greater than 35 IU/l in six (100%) out of six female patients (range 39-100 IU/l, mean 56) as against one (3%) of 35 female controls (range 3-106 IU/l, mean 16; P less than 0-001). The recognized pitfalls in interpreting CPK activity were avoided. In all of sixteen randomly selected patients isoenzyme studies confirmed that muscle is the source of the enzyme. There was a significant correlation between CPK activity and both spinal flexion and the reciprocal of finger-to-floor distance (P less than 0-5 in each case).
PATHOGENESIS OF PNEUMOCOCCUS INFECTIONS IN MICE
Authors: Geoffrey Rake
Journal: The Journal of Experimental Medicine (1936)

Unprepared mice given intranasal inoculations of certain strains of pneumococci develop pneumonia. The proportion of inoculated mice which will show the pneumonia at autopsy is dependent upon the strain and type of organism and the breed of mice used. It has been shown that, with the technique employed, the pneumococci reach the lower respiratory tract and alveoli almost immediately; moreover, that an invasion of the blood stream occurs very rapidly and can be demonstrated in a third of mice during the first 10 minutes. There is some evidence that invasion of the tissues and the blood stream may occur both through the upper respiratory tract, probably the nasal mucosa, and through the alveolar walls. It is uncertain which route of invasion, if either, is of the most importance. It has been possible to produce pneumonia by direct intravenous inoculation of pneumococci. It may be that the pneumonia is favored by a reaction at the point of invasion through the alveolar walls in the intranasally inoculated mice, but the results of the intravenous inoculation make it clear that such a local lesion is unnecessary for the production of pneumonia in mice.
Use of a Picosecond Pulse Duration Laser With Specialized Optic for Treatment of Facial Acne Scarring
Authors: Jeremy A. Brauer, Viktoryia Kazlouskaya, Hamad Alabdulrazzaq, Yoon Soo Bae, Leonard J. Bernstein, Robert Anolik, Patricia A. Heller, Roy G. Geronemus
Journal: JAMA Dermatology (2014)

Fractional laser technology is routinely used in the treatment of acne scarring, with thermal injury resulting in collagen synthesis and remodeling. Use of a picosecond pulse duration with a diffractive lens array may be a new technologic advancement in the treatment of acne scarring.To investigate the safety and efficacy of a 755-nm alexandrite picosecond pulse duration laser with diffractive lens array for the treatment of facial acne scarring.This single-center, prospective study performed in a private practice with a dedicated research department included patients with clinically diagnosed scarring secondary to inflammatory or cystic acne.Patients received 6 treatments with a 755-nm picosecond laser with a spot size of 6 mm, fluence of 0.71 J/cm2, repetition rate of 5 Hz, and pulse width of 750 picoseconds in combination with a diffractive lens array, allowing for greater surface area and pattern density per pulse.The pain and satisfaction scores for overall appearance and texture were recorded. Masked assessment of clinical photographs and analysis of 3-dimensional volumetric data were performed. Biopsy specimens were obtained for independent histologic evaluation by 2 investigators at baseline and at 3 months after last treatment.Fifteen women and 5 men (mean age, 44 years; age range, 27-61 years) with Fitzpatrick skin types I through V and facial acne scarring were enrolled. The mean pain score was 2.83 of 10. Patients were satisfied to extremely satisfied with improvement in appearance and texture at their final treatment and follow-up visits. The masked assessment scores of 17 patients were 1.5 of 3 and 1.4 of 3 at 1 and 3 months, respectively (a score of 0 indicates 0%-25% improvement and a score of 3 indicates >75% improvement). A 3-dimensional analysis revealed a mean 24.3% improvement in scar volume, maintained at 1 (24.0%) and 3 (27.2%) months after treatment. Histologic analysis revealed elongation and increased density of elastic fibers, with an increase in dermal collagen and mucin.Treatment of facial acne scars with a diffractive lens array and 755-nm picosecond laser produced improvement in appearance and texture at 3 months after the last treatment, with objective findings similar to those published for a series of fractional ablative laser treatments. Histologic findings suggest that improvement in scarring from this treatment goes beyond remodeling of collagen.
Incidentally Detected Thrombocytopenia in Healthy Mothers and Their Infants
Authors: R F Burrows, J G Kelton
Journal: New England Journal of Medicine (1988)

The unexpected discovery of thrombocytopenia in an asymptomatic pregnant woman--often considered to be equivalent to the diagnosis of idiopathic thrombocytopenic purpura--leads to a variety of interventions, including delivery by cesarean section. However, the actual risk to mothers and their infants posed by incidentally noted thrombocytopenia is not known. To investigate this issue, we performed a prospective study of a group of normal women who delivered at our medical center and their infants during a period of one year. Of the 2263 women who delivered during the year, 1357 were considered to be normal. One hundred twelve of the women (8.3 percent) had mild thrombocytopenia (range of platelet counts, 97 to 150 x 10(9) per liter). The thrombocytopenia had no discernible clinical effect on the women or their infants. The frequency of thrombocytopenia in babies born to this group of women was not appreciably different from that in babies born to the other normal patients who did not have thrombocytopenia, and none of the infants of women with thrombocytopenia had a platelet count of less than 100 x 10(9) per liter. This study demonstrates that the frequency of mild thrombocytopenia is high in normal pregnant women at term and that the thrombocytopenia appears to have no adverse effect on either the mothers or their infants. To perform obstetrical interventions such as cesarean section because of thrombocytopenia in these mothers is not justified.
954 BI 201335, A POTENT HCV NS3 PROTEASE INHIBITOR, IN TREATMENT-NAIVE AND -EXPERIENCED CHRONIC HCV GENOTYPE-1 INFECTION: GENOTYPIC AND PHENOTYPIC ANALYSIS OF THE NS3 PROTEASE DOMAIN
Authors: G. Kukolj, Y. Benhamou, M.P. Manns, M. Bourlière, S. Pol, M. Schuchmann, M. Cartier, D. Huang, L. Lagacé, G. Steinmann, J.O. Stern
Journal: Journal of Hepatology (2009)
Like the plagues of Egypt
Authors: G. Dunea
Journal: BMJ (1996)

<h3>Introduction</h3> Mycoplasma genitalium (M gen) is a bacteria STI with increasing number of cases among the sexual health clinic patients. We reviewed all the cases tested for M gen infection and the characteristics and association factors for the M gen infection. <h3>Methods</h3> An observational retrospective cross-sectional study reviewing all the patients testing for M gen from 01/01/21 to 31/12/21. We collected data from the electronic patient records and analysed in SPSS version 25. <h3>Results</h3> During the study period, 774 M gen tests were processed and 112 (14.4%) were positive via Transcription-mediated Amplification (TMA) at the local lab from 94 patients. The median age of M gen positive patient was 24 (IQR 21,30), 60% were male and 80% were heterosexual. The most common presentation in the male patient was urethral discharge (63%) and lower abdominal pain was the most common presentation among the female patients (54.5%). The other characteristics are shown in table (1). 79 (71.1%) received doxycycline and azithromycin and 46 (41%) received moxifloxacin according to antibiotic sensitivity result. Repeated testing confirmed that 42.3% were successfully treated and 17.1% were identified as treatment failures. On multivariate logistic regression analysis, previous M gen infection (p-0.013), being M gen contact (p-0.001), alcohol intake (p&lt;0.005) and Non-gonococcal urethritis (NGU) at presentation (p-0.004) were associated with M gen infection. <h3>Discussion</h3> The prevalence of M gen infection among the patients attending the sexual health clinic is higher than expected. It is also important to know the antibiotic resistance prevalence of M gen infection to reduce treatment failure.
Cromolyn Sodium Therapy for Chronic Perennial Asthma
Authors: J. Crisp
Journal: JAMA (1974)

Cromolyn sodium as an aid in the prophylaxis of chronic asthma was compared with lactose in a nine-week double-blind study. Improvement occurred with cromolyn treatment in 35 of 40 children (87%) and in two with placebo. Over a period of 2 1/2 to 4 years, it has remained effective in 22 of 28 patients (80%), became ineffective in 4, and was no longer required in 2. Except for a temporary rash in one patient, there was no evidence of intolerance or side effects. Among 18 patients who had been receiving corticosteroid therapy before the study, the steroid has been omitted entirely in 12 patients and reduced in 6. (<i>JAMA</i>229:787-789, 1974)
Urinary Tract Infection
Authors: Kalpana Gupta, Larissa Grigoryan, Barbara Trautner
Journal: Annals of Internal Medicine (2017)

Urinary tract infections (UTIs) are common in both inpatient and outpatient settings. This article provides an evidence-based, clinically relevant overview of management of UTIs, including screening, diagnosis, treatment, and prevention. Conditions covered include acute cystitis (both uncomplicated and complicated), catheter-associated UTI, and asymptomatic bacteriuria in both women and men.
No evidence for therapeutic effect of topical ciclosporin in oral lichen planus
Authors: N.J. Levell
Journal: British Journal of Dermatology (2006)

Journal Article No evidence for therapeutic effect of topical ciclosporin in oral lichen planus Get access N.J. Levell N.J. Levell Dermatology Department, Norfolk and Norwich University Hospital, Norwich NR4 7UY, U.K. E‐mail: nick.levell@nnuh.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 2, 1 August 2006, Pages 487–488, https://doi.org/10.1111/j.1365-2133.2006.07334.x Published: 01 August 2006
Cervical Cancer: Prevention, Diagnosis, and Therapeutics
Authors: M. F. Janicek, H. E. Averette
Journal: CA A Cancer Journal for Clinicians (2001)

Cervical cancer is a leading cause of cancer deaths in women worldwide. Because of its association with human papilloma virus infection, as well as the ability to screen for premalignant stages of the disease, it is now largely a preventable disease. This article describes the molecular basis for cervical cancer, and presents a clinical overview of current treatment approaches and technological advances, emphasizing the unique aspects of this viral disease as it relates to the immune system and vaccination or other immunotherapeutic strategies.
UK blood service could be part privatised by the government
Authors: H. Mooney
Journal: BMJ (2011)

<h3>ABSTRACT</h3> Increased copy number of the 5-enolpyruvylshikimate-3-phosphate synthase (<i>EPSPS</i>) gene confers resistance to glyphosate, the world’s most-used herbicide. There are typically three to eight <i>EPSPS</i> copies arranged in tandem in glyphosate-resistant populations of the weed kochia (<i>Kochia scoparia</i>). Here, we report a draft genome assembly from a glyphosate-susceptible kochia individual. Additionally, we assembled the <i>EPSPS</i> locus from a glyphosate-resistant kochia plant by sequencing a kochia bacterial artificial chromosome library. These resources helped reconstruct the history of duplication in the structurally complex <i>EPSPS</i> locus and uncover the genes that are co-duplicated with <i>EPSPS</i>, several of which have a corresponding change in transcription. The comparison between the susceptible and resistant assemblies revealed two dominant repeat types. We discovered a FHY3/FAR1-like mobile genetic element that is associated with the duplicated <i>EPSPS</i> gene copies in the resistant line. We present a hypothetical model based on unequal crossing over that implicates this mobile element as responsible for the origin of the <i>EPSPS</i> gene duplication event and the evolution of herbicide resistance in this system. These findings add to our understanding of stress resistance evolution and provide an example of rapid resistance evolution to high levels of environmental stress.