tbuckley/cabot-search huggingface dataset:
Pulmonary monosporosis: An uncommon pulmonary mycotic infection
Authors: P. C. Reddy, C. S. Christianson, D. F. Gorelick, H. W. Larsh
Journal: Thorax (1969)

Pulmonary monosporosis is an uncommon form of fungal disease of the lung and bronchorespiratory passages. To date, only six isolated cases have been reported in the literature. It is the purpose of this communication to present the clinical findings, laboratory data, radiographic appearance, and description of the pathology findings in three additional cases identified at the Missouri State Sanatorium. The fungus <i>Monosporium apiospermum</i> is present in the soil and has a world-wide distribution. It has been shown to produce localized lesions in the foot called maduromycosis. Pulmonary infection due to this fungus has no characteristic clinical pattern, but the cultural characteristics of <i>M. apiospermum</i> permit specific identification. Histologically, the pulmonary involvement shows a variegated non-specific pattern. In the majority of cases, well-defined, predisposing factors are present. A review of the reported six cases and a study of our three cases strengthens our belief that the organism acts as a secondary invader. To date, no mode of therapy has appeared to exert a beneficial influence on the course of the disease. To our knowledge, no clinical trial using any of the antifungal agents has been attempted. Surgical treatment is indicated whenever the lesions are considered resectable. From our observations, we conclude that pulmonary infection with <i>M. apiospermum</i> could be recognized more frequently if physicians were more aware of this fungal infection and if the mycology laboratories would take additional care in specific identification.
Methylenetetrahydrofolate reductase mutation (677C → T) negatively influences plasma homocysteine response to marginal folate intake in elderly women
Authors: Gail P.A Kauwell, Chad E Wilsky, James J Cerda, Kelli Herrlinger-Garcia, Alan D Hutson, Douglas W Theriaque, Anita Boddie, Gail C Rampersaud, Lynn B Bailey
Journal: Metabolism (2000)
Endocytoscopy assists in the intraoperative diagnosis of carcinoma in a patient with chronic pancreatitis
Authors: G. Rao, R. Pradeep, M. Mansard, C. Ramji, R. Banerjee, D. Nageshwar Reddy
Journal: Endoscopy (2007)

The endocytoscopy system has been used successfully for direct histological imaging of the gastrointestinal mucosa during endoscopy [1] [2] [3]. However, there are no published reports on the intraoperative use of the endocytoscope. This is the first report describing the intraoperatiave use of the endocytoscope for the detection of carcinoma in a patient with chronic pancreatitis.
Abstract P1-04-01: Loss of Notch4 reduces mammary tumorigenesis by MYC and activated KRAS
Authors: EM Rodriguez, JM Bishop
Journal: Cancer Research (2012)

Abstract Over-expression of Notch receptors and aberrant Notch signaling have been reported in both preinvasive ductal carcinoma in situ and invasive breast cancer. The Notch 4 receptor, in particular, is preferentially activated in human breast cancer stem cell-enriched populations, and inhibition of Notch 4 reduces tumor formation of human breast cancer cells in xenograft models (Harrison, 2010). Myc gene amplification has also been found in about 15% of breast tumors, and 22%–35% of tumors exhibit overexpression of Myc at the transcriptional level. Transgenic mice over-expressing MYC develop invasive adenocarcinomas and preferentially harbor secondary activating mutations in KRas. We examined whether Notch receptors were activated in mouse mammary tumors over-expressing MYC and activated KRAS (KRASV12) and found Notch 4 to be significantly activated in these tumors compared to normal mammary tissue. Furthermore, Notch 4 was localized to the nucleus in the tumors over-expressing MYC and KRASV12, but not in mammary glands over-expressing MYC or activated KRASV12 alone. To examine the requirement of Notch4 in mammary tumorigenesis by MYC and KRASV12, we transplanted mammary epithelial cells isolated from Notch4 knockout mice and wild-type mice that have been transduced with MYC and KRASV12 into the mammary glands of syngeneic mice. There was a significant reduction in the onset of tumorigenesis in mammary glands that had been transplanted with mammary epithelial cells lacking Notch4. These findings suggest that Notch4 is important in mammary tumorigenesis induced by cooperation of MYC and activated RAS. We are currently examining the relevance of Nocth4 activation in human breast cancers that over-express MYC and the mechanism by which Notch4 promotes tumorigenesis by Myc and activated RAS. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-04-01.
THE VALUE OF TUBERCULIN TR AS A DIAGNOSTIC AND THERAPEUTIC AGENTIN THE RECOGNITION AND TREATMENT OF TUBERCULOSIS OF THE EYE; WITH REPORT OF CASES.
Authors: CHARLES STEDMAN BULL
Journal: JAMA (1907)

Tuberculosis of the eye and its adnexa is a rather rare disease, though I believe not so uncommon as reported, for its presence is sometimes not recognized from lack of observation. We know that all parts of the eye may suffer secondarily from extension of the disease from lesions elsewhere in the body, yet it is a well-recognized fact that the ocular lesion may be primary, and the only existing focus of infection in the organism. It seems to be a well-established fact that tuberculosis attacks by preference the posterior segment of the eyeball, especially the more highly vascularized portion, like the chorioid, extending to the retina and thence by the blood vessels to the anterior segment of the eye. When the disease spreads from the interior to the exterior, the foci of disease may always be found at the filtration angle. The presence of indurated glands in anterior tuberculosis
Abstract P3-10-20: The Prognostic Relevance of Serum CA27.29 level in Primary Breast Cancer Patients before Adjuvant Chemotherapy — Results of the German SUCCESS Trial
Authors: JK Neugebauer, BK Rack, C Schindlbeck, I Schrader, H Tesch, A Schneeweiss, T Zwingers, W Lichtenegger, MW Beckmann, HL Sommer, K Friese, W Janni
Journal: Cancer Research (2010)

Abstract Background: While tumor markers are frequently used to assess treatment efficacy in metastatic breast cancer, there is lack of evidence regarding the role of MUC-1 markers in primary disease. The value of CA27.29 in the adjuvant setting was prospectively evaluated in the German multicenter SUCCESS study. Material and Methods: The German SUCCESS trial is a multicenter phase III study comparing FEC-Docetaxel (Doc) vs. FEC-Docetaxel-Gemcitabine (Doc-G) and 5 versus 2 years of Zoledronate as adjuvant treatment in patients with node positive or high risk node negative primary breast cancer. In this trial serum CA27.29 level has been prospectively evaluated in 3202 patients before and immediately after adjuvant chemotherapy as well as 2 and 5 years thereafter. CA27.29 was measured with the ST AIA-PACK CA27.29 reagent using MUC-1 for AIA-600II (Tosoh Bioscience, Tessenderlo, Belgium). The cutoff for positivity was &amp;gt;31 U/ml. Results: Mean CA27.29 serum level before adjuvant chemotherapy was 19,3 U/ml (SD +/− 15,5) in both arms. 8,0% (n=127) of patients in the FEC-Doc-G arm and 7,4% (n= 120) in the FEC-Doc arm had marker levels of more than 31 U/ml. Mean CA27.29 serum levels were significantly higher in patients with lobular carcinoma (p=0.001), with positive lymph nodes (p=0.02) and post-menopausal patients (P&amp;lt;0.001). After a median follow-up period of 34 months 233 patients relapsed and 108 patients died. CA27.29 before chemotherapy was a significant prognostic marker for disease-free survival (DFS) (P&amp;lt;0.0001) and overall survival (OAS) (P&amp;lt;0.0001) in univariate and multivariate analysis. Conclusion: These findings indicate the independent prognostic relevance of serum CA27.29 levels in primary breast cancer patients before adjuvant treatment. Further follow-up within the SUCCESS trial will show whether initial CA27.29 level could serve as a tool for adjuvant treatment monitoring. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-10-20.
Textbook of Child and Adolescent Psychiatry
Authors: Ruth P. Zager
Journal: JAMA (1992)

This multiauthored child and adolescent psychiatry text aims to be a "clinically focused textbook that would encompass the state of the art and the science" directed toward the "student, general resident, career resident in child and adolescent psychiatry, clinician, and also pediatrician." The first of 11 sections provides a history of the field, which should be especially interesting to experienced child psychiatrists. The second section covers methods of evaluating and diagnosing children and adolescents with psychological and behavioral problems, and includes two very helpful chapters reviewing and evaluating currently available rating scales, questionnaires, and psychological and neuropsychological tests. Various psychological disorders in children and adolescents, generally arranged to correspond with the nomenclature and classification for these disorders used in the criteria-based classification system of the<i>Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised</i>, comprise sections 3 through 9. Chapters in section 10 deal with "Special Issues" and include
Forms of Psychotherapy in Use in Ancient Greece and Among the Population of Modern Greece
Authors: M.G. Papageorgiou
Journal: Psychotherapy and Psychosomatics (1969)

Other Types| February 12 2010 Forms of Psychotherapy in Use in Ancient Greece and Among the Population of Modern Greece Subject Area: Psychiatry and Psychology M.G. Papageorgiou M.G. Papageorgiou Athens Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1969) 17 (2): 114–118. https://doi.org/10.1159/000286018 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation M.G. Papageorgiou; Forms of Psychotherapy in Use in Ancient Greece and Among the Population of Modern Greece. Psychother Psychosom 1 February 1969; 17 (2): 114–118. https://doi.org/10.1159/000286018 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1969Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Drug Monitoring of Surgical Patients
Authors: David A. Danielson
Journal: JAMA (1982)

Intensive drug monitoring of surgical patients was carried out on selected wards in five hospitals in the United States, Scotland, and New Zealand from 1977 through 1981. This report describes the methods and some findings from the monitoring of 5,232 such patients. Patients received, on the average, nine drugs on the ward, and adverse reactions were associated with 2.2% of these drug orders. Of the 1,150 drug-attributed adverse reactions, only 62 were considered "major" by the attending physician, and 35 (affecting 20 patients) were termed "life threatening." There were no drug-attributed deaths.
Mattresses, microenvironments, and multivariate analyses
Authors: P. J Fleming
Journal: BMJ (2002)

Papers p 1007 

Despite the success of “Back to Sleep” campaigns in many countries, sudden infant death syndrome remains responsible for the largest group of deaths in infants between one month and one year of age.1 The importance of sleeping in the prone position as a contributory factor has led to studies of the pathophysiological effects of the prone position on the infant and to studies of microenvironmental factors that might contribute to this risk. 2 3 The carefully conducted study by Tappin and colleagues in this issue (p 1007) is set in Scotland and emphasises the potential importance of the infant's microenvironment during sleep as a contributory factor to the risk of sudden infant death syndrome, but as emphasised by the authors, caution must be exercised in the interpretation of these results.4

Tappin and colleagues have shown an apparently increased risk of sudden infant death syndrome for infants sleeping on a mattress previously used by another infant (54% cases, 28% controls), confirming the observation by the same group in an earlier study.5 The previous Scottish study was criticised because infants sharing beds with adults were included with infants sleeping on mattresses used by …
Surgeon's return to work highlights need for urgent reform of GMC
Authors: C. Dyer
Journal: BMJ (2011)

The UK government is considering giving the General Medical Council the right to appeal against decisions of its independent panels that it considers are too lenient, after the House of Commons Health Committee urged ministers in July “to move quickly to make the necessary legislative amendments” ( BMJ Careers , 30 Jul, http://careers.bmj.com/careers/advice/view-article.html?id=20004023)

But any change could be delayed by the Department of Health’s decision to ask the Law Commission, the official law reform body, to look at the whole system for regulating healthcare and social care professionals, with a view to simplifying it.

The issue of the GMC’s powers was highlighted this week when Gideon Lauffer, a former consultant surgeon, returned to work even though the GMC had asked the panel considering his case to strike him off. Instead …
THE PROGNOSIS OF PLEURISY WITH EFFUSION
Authors: FRED W. GAARDE
Journal: JAMA (1930)

The frequency with which pleural adhesions are found at necropsy and accidentally by roentgenologic examination would indicate that the milder form of pleurisy is common. Undoubtedly patients often recover without the diagnosis of pleurisy having been made. Because of the obvious difficulty of classifying the milder cases of pleurisy, it is not feasible to include them in a study of the prognosis in cases of idiopathic pleurisy, although they may be of the same etiology and type as those of pleurisy with effusion. If it were possible to classify the cases accurately, conclusions regarding the outcome of primary pleurisy would be greatly modified. This study is limited to the primary or idiopathic pleurisy with effusion in which there is an appreciable accumulation of serous fluid, and does not include the idiopathic pleurisy of lesser degree. The etiology is generally considered to be tuberculous and, although the condition is termed primary
Changing the "leadership" of the NHS
Authors: R. Smith
Journal: BMJ (2003)

programmes, can have a beneficial impact on orphans' school attendance, training, and productivity.The cost of treating one person with antiretroviral drugs for a year is equivalent to that of preventing almost 50 cases.Potts and Walsh (p 1389) state that the priority should be prevention, not antiretroviral treatment.They explain the current impact of the epidemic in India and strategies available to contain it.
THE DEVELOPMENT OF HYPERSENSITIVE LYMPHOCYTES IN CELL CULTURE
Authors: Haim Ginsburg, Nurit Hollander, Michael Feldman
Journal: The Journal of Experimental Medicine (1971)

An in vitro cell-mediated immune response to pokeweed mitogen (PWM) is described. Rat lymphocytes were stimulated by PWM, by phytohemagglutinin (PHA), and by concanavalin A (ConA). In the presence of PWM only a fraction of the lymphocytes underwent blastogenesis. This was in contrast to the apparent total blastogenesis obtained in response to PHA or ConA. When blast cells derived from each of the mitogens were plated on rat fibroblast monolayer in the absence of mitogen they differentiated into a distinct type of lymphocyte termed "secondary lymphocyte." Addition of mitogens to cultures of these lymphocytes resulted in a retransformation to blast cells. The secondary lymphocytes were tested for their ability to effect lysis in the presence of each of the three mitogens. In. the presence of PWM, lysis of fibroblasts produced by PWM-lymphocytes was considerably more efficient than lysis obtained by ConA- or PHA-lymphocytes. No difference in effect on target fibroblasts was obtained when the three types of secondary lymphocytes were tested in the presence of either PHA or ConA. The stimulating action of PWM on lymphocytes was shown to be immunologically specific. No such specificity was found in the case of PHA or ConA. The results are interpreted to indicate that PWM combines with cell membranes and acts on the lymphocytes as a "transplantation antigen." Lymphocytes capable of responding to "PWM-transplantation antigen" transform to blast cells capable of specifically lysing PWM-conjugated fibroblasts. In the absence of the mitogen, PWM-induced blast cells differentiate to lymphocytes hypersensitive to PWM.
Acral pseudolymphomatous angiokeratoma of children (APACHE): a case report and immunohistological study
Authors: M. HARA, J. MATSUNAGA, H. TAGAMI
Journal: British Journal of Dermatology (1991)

Journal Article Acral pseudolymphomatous angiokeratoma of children (APACHE): a case report and immunohistological study Get access M. HARA, M. HARA Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan Dr M. Hara, Department of Dermatology, Tohoku University School of Medicine, 1–1 Seiryomachi, Aoba‐ku, Sendai 980, Japan. Search for other works by this author on: Oxford Academic Google Scholar J. MATSUNAGA, J. MATSUNAGA Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan Search for other works by this author on: Oxford Academic Google Scholar H. TAGAMI H. TAGAMI Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 4, 1 April 1991, Pages 387–388, https://doi.org/10.1111/j.1365-2133.1991.tb00605.x Published: 01 April 1991
Copy Number Variants in Schizophrenia: Confirmation of Five Previous Findings and New Evidence for 3q29 Microdeletions and VIPR2 Duplications
Authors: Douglas F. Levinson, Jubao Duan, Sang Oh, Kai Wang, Alan R. Sanders, Jianxin Shi, Nancy Zhang, Bryan J. Mowry, Ann Olincy, Farooq Amin, C. Robert Cloninger, Jeremy M. Silverman, Nancy G. Buccola, William F. Byerley, Donald W. Black, Kenneth S. Kendler, Robert Freedman, Frank Dudbridge, Itsik Pe'er, Hakon Hakonarson, Sarah E. Bergen, Ayman H. Fanous, Peter A. Holmans, Pablo V. Gejman
Journal: American Journal of Psychiatry (2011)

Objective: To evaluate previously reported associations of copy number variants (CNVs) with schizophrenia and to identify additional associations, the authors analyzed CNVs in the Molecular Genetics of Schizophrenia study (MGS) and additional available data. Method: After quality control, MGS data for 3,945 subjects with schizophrenia or schizoaffective disorder and 3,611 screened comparison subjects were available for analysis of rare CNVs (<1% frequency). CNV detection thresholds were chosen that maximized concordance in 151 duplicate assays. Pointwise and genewise analyses were carried out, as well as analyses of previously reported regions. Selected regions were visually inspected and confirmed with quantitative polymerase chain reaction. Results: In analyses of MGS data combined with other available data sets, odds ratios of 7.5 or greater were observed for previously reported deletions in chromosomes 1q21.1, 15q13.3, and 22q11.21, duplications in 16p11.2, and exon-disrupting deletions in NRXN1. The most consistently supported candidate associations across data sets included a 1.6-Mb deletion in chromosome 3q29 (21 genes, TFRC to BDH1) that was previously described in a mild-moderate mental retardation syndrome, exonic duplications in the gene for vasoactive intestinal peptide receptor 2 (VIPR2), and exonic duplications in C16orf72. The case subjects had a modestly higher genome-wide number of gene-containing deletions (>100 kb and >1 Mb) but not duplications. Conclusions: The data strongly confirm the association of schizophrenia with 1q21.1, 15q13.3, and 22q11.21 deletions, 16p11.2 duplications, and exonic NRXN1 deletions. These CNVs, as well as 3q29 deletions, are also associated with mental retardation, autism spectrum disorders, and epilepsy. Additional candidate genes and regions, including VIPR2, were identified. Study of the mechanisms underlying these associations should shed light on the pathophysiology of schizophrenia.
THE SURGICAL ASPECTS OF PANCREATITIS.
Authors: WILLIAM J. MAYO
Journal: JAMA (1902)

Balzer, in 1879, first described acute pancreatitis with fat necrosis. Little attention was attracted to the subject, however, and it was not until Fitz, ten years later, wrote his classical papers that the medical world really became aware of the inflammatory diseases of the pancreas. Fitz soon after pointed out the fact that many supposed cysts of the pancreas due to traumatism were really accumulations of fluid in the lesser cavity of the peritoneum and the omental bursæ. A proper understanding of chronic pancreatitis has been largely due to Robson, who first noticed the disease in connection with his operative work upon the biliary tract. In fact, the surgical study of the inflammatory diseases of the pancreas may be said to be the result of an inquiry into the causation of some of the complications of gallstone disease. The reason for this depends upon certain anatomic facts. Brewer, discussing the
Unlike ghrelin, obestatin does not exert any relevant activity in chondrocytes
Authors: R. Lago, R. Gomez, C. Dieguez, J. J Gomez-Reino, F. Lago, O. Gualillo
Journal: Annals of the Rheumatic Diseases (2007)

could be intraindividual variations and the moderate reproducibility of PEP. 9 10 Therefore, besides the use of a placebo group, a valid and reproducible test is needed for follow-up evaluation of RP trials.