tbuckley/cabot-search huggingface dataset:
Hubert John (“Paddy”) Warrick
Authors: Mary Martin
Journal: BMJ (2006)

​FormerFormer medical director Grace General Hospital, St John's, Newfoundland, Canada (b 1923; q St Mary's Hospital, London, 1955), d 24 April 2006.



Figure 1



Hubert John Warrick (“Paddy”) began general practice in Newfoundland in 1957. From 1967 to 1987 he was medical director of the Grace General Hospital in St John's. From 1992 to August 2005 he wrote a weekly health column in the Telegram, the St John's daily newspaper. As health columnist, he combined his love of writing and his concern for current health issues. While attending St Mary's Medical School he supported his family by working for the British Consulate, escorting visiting dignitaries. His most memorable encounter was when he introduced Gerhard Domaqk, the inventor of sulpha drugs, to Alexander Fleming, the discoverer of penicillin. Predeceased by his wife, Pat, he leaves five children and 12 grandchildren.
Magnified endoscopic images of gastric MALT lymphoma before and after treatment
Authors: S. Ono, M. Kato, Y. Ono, M. Nakagawa, Y. Shimizu, M. Asaka
Journal: Endoscopy (2007)

Recently, the increasing utility of magnifying endoscopy in the diagnosis of gastritis and gastric cancer has been reported [1] [2]. However, there have been no reports on magnified endoscopic images of nonepithelial gastric tumors. We conducted a long-term follow-up of gastric mucosa-associated lymphoid tissue (MALT) lymphoma by magnifying endoscopy.
Growth of Lungs after Transplantation in Infants and in Children Younger than 3 Years of Age
Authors: ALAN H. COHEN, GEORGE B. MALLORY, KATHY ROSS, DEBORAH K. WHITE, ERIC MENDELOFF, CHARLES B. HUDDLESTON, JAMES S. KEMP
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

We report serial measurements of lung volume and airflow in small children after lung transplantation. We expected that immature lungs could grow and develop normal volumes after transplantation, despite denervation and immunosuppression. At predetermined intervals, functional residual capacity (FRC) and forced expiratory flow were measured 86 times in 23 recipients younger than 3 yr of age (age at transplant, 13.2 ± 8.4 mo; range, 2 to 30 mo). FRC was measured using open-circuit N2 washout. Maximal flow at FRC by rapid thoracoabdominal compression was used to distinguish between infants with and those without airflow obstruction. The slope of FRC (in milliliters) versus body length (in centimeters) for all 23 recipients studied was 8.63. For those children without obstruction (flow at FRC ⩾ 0.9 FRC/s, n = 16), the slope of FRC versus length was 6.61. The coefficient of variation for FRC measurements for all infants was 3.90 ± 2.80% (range, 0.3 to 16.9%). We conclude that in the absence of significant airflow obstruction the volume of transplanted immature lungs increases at a rate similar to that reported in normal infants.
Effect of Nociceptin in Acid-evoked Cough and Airway Sensory Nerve Activation in Guinea Pigs
Authors: Min-Goo Lee, Bradley J. Undem, Claire Brown, Michael J. Carr
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Rationale: Nociceptin/orphanin FQ has been reported to inhibit capsaicin- and mechanically provoked cough in animal models, but the mechanism of this effect has not been elucidated.Objectives: The objectives of this study were to determine whether nociceptin inhibits acid-evoked cough in conscious animals and to evaluate the mechanism of this effect.Methods: We tested the effect of nociceptin on acid-induced cough in conscious guinea pigs and acid-induced nerve activation in airway-specific vagal sensory neurons using calcium imaging techniques and the gramicidin-perforated patch clamp technique.Measurements and Main Results: Nociceptin (3 mg/kg, intraperitoneal) effectively inhibited acid-evoked cough in guinea pigs by nearly 70%. Acid (pH 5) increased intracellular free calcium in acutely dissociated vagal jugular ganglionic neurons. The acid-induced increase in intracellular calcium was inhibited by a selective transient receptor potential vanilloid-1 antagonist, 5-iodo-resiniferatoxin (1 μM, ∼ 80% reduction). The inhibitory effect of 5-iodo-resiniferatoxin on acid-induced increases in calcium was mimicked by nociceptin (0.1 μM). In gramicidin-perforated patch clamp recordings on airway-specific capsaicin-sensitive jugular ganglion neurons, acid (pH 5) induced two distinct inward currents. A transient current was evoked that was inhibited by amiloride and a sustained current was evoked that was inhibited by 5-iodo-resiniferatoxin. Nociceptin selectively inhibited only the sustained component of acid-induced inward current.Conclusion: These results indicate that the inhibitory effect of nociceptin on acid-induced cough may result from a direct inhibitory effect on peripheral C-fiber activity caused by the selective inhibition of acid-induced transient receptor potential vanilloid-1 activation.
Arachidonic acid metabolites in the pathogenesis of psoriasis
Authors: Elizabeth Wong, Pauline Dowd, R.D.R. Camp, Anne Kobza Black, P. Woolard, M.W. Greaves
Journal: British Journal of Dermatology (1984)

Journal Article Arachidonic acid metabolites in the pathogenesis of psoriasis Get access Elizabeth Wong, Elizabeth Wong Institute of Dermatology, Lisle Street, London Search for other works by this author on: Oxford Academic Google Scholar Pauline Dowd, Pauline Dowd Institute of Dermatology, Lisle Street, London Search for other works by this author on: Oxford Academic Google Scholar R.D.R. Camp, R.D.R. Camp Institute of Dermatology, Lisle Street, London Search for other works by this author on: Oxford Academic Google Scholar Anne Kobza Black, Anne Kobza Black Institute of Dermatology, Lisle Street, London Search for other works by this author on: Oxford Academic Google Scholar P. Woolard, P. Woolard Institute of Dermatology, Lisle Street, London Search for other works by this author on: Oxford Academic Google Scholar M.W. Greaves M.W. Greaves Institute of Dermatology, Lisle Street, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Page 29, https://doi.org/10.1111/j.1365-2133.1984.tb05250.x Published: 01 July 1984
Increased CD40 ligand, C-reactive protein, and platelet-monocyte binding in patients with type 1 diabetes mellitus
Authors: Scott A. Harding, Andrew J. Sommerfield, Jaydeep Sarma, Patrick J. Twomey, David E. Newby, Brian M. Frier, Keith A.A. Fox
Journal: Journal of the American College of Cardiology (2003)
Emergency Vascular Surgery: A Practical Guide
Authors: Todd R. Vogel
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Etiological and Environmental Factors
Authors: Waldomiro Dantas
Journal: JAMA (1975)

<h3>To the Editor.—</h3> About the article by Wynder and Mabuchi, "Etiological and Environmental Factors," concerning esophageal cancer (226:1546, 1973), I would like to report that in some areas of my country, especially in the south states, such as Parañá, Santa Catarina, and Rio Grande do Sul, some cases of cancer of the esophagus are related with the habit many people have of drinking maté tea without sugar, in a gourd through a silver straw, at very hot temperature (<i>chimarrão</i>). I think, as do some Brazilian surgeons (G. V. Artigas, MD, F. C. Becker, MD, unpublished data), that the high temperature of the tea and the assiduity of the habit (daily for many years) account, at least in part, for the prevalence of cancer of the esophagus in these people.
Changes in gastric alkaline secretion by ulcer healing drugs.
Authors: M Guslandi
Journal: Gut (1988)

reported in the controlled trials.It is very difficult to differentiate the diarrhoea of therapy and that of the colitis without a coticurrently studied placebo group.Further research will be necessary to truly determine the incidence of this proposed complication in the general population of ulcerative colitis patients treated with olsalazine sodium.
Laboratory-Acquired Typhus Fevers
Authors: LARRY J. WRIGHT
Journal: Annals of Internal Medicine (1968)

Laboratory-acquired typhus fevers occurred in four patients. Early effective antibiotic therapy in all four and previous vaccination in the two with epidemic typhus resulted in the absence of the rash that is a cardinal sign of naturally occurring typhus fevers. Liver function abnormalities, present in three of the four patients, have been infrequently reported in successfully treated patients but may well be typical of the naturally occurring diseases. The need for the development of more effective vaccines and the attendant risks to laboratory workers are discussed.
Atrial Natriuretic Peptide and Atrial Pressure in Patients with Congestive Heart Failure
Authors: Anthony E.G. Raine, Paul Erne, Ernst Bürgisser, Franco B. Müller, Peter Bolli, Felix Burkart, Fritz R. Bühler
Journal: New England Journal of Medicine (1986)

To define the relation between atrial pressures and the release of atrial natriuretic peptide, we measured plasma concentrations of the peptide in 26 patients with cardiac disease--11 with normal atrial pressures and 15 with elevated atrial pressures (11 of these 15 had elevated pressures in both atria). Mean peptide levels (+/- SEM) in the peripheral venous blood were increased in the 11 patients with cardiac disease and normal atrial pressures, as compared with 60 healthy controls (48 +/- 14 vs. 17 +/- 2 pmol per liter). In the patients with elevated atrial pressures, peptide concentrations were increased twofold in peripheral venous, right atrial, pulmonary arterial, and systemic arterial plasma, as compared with the concentrations in the patients with normal atrial pressures. A step-up in peptide concentration was seen between the venous and right atrial plasma (P less than 0.002) and between the pulmonary and systemic arterial plasma (P less than 0.01), suggesting release of the peptide from the atria. A linear relation was found between right atrial pressure and right atrial peptide concentration (r = 0.835, P less than 0.001) and between pulmonary wedge pressure and the systemic arterial peptide concentration (r = 0.866, P less than 0.001). Right atrial pressure and the peptide concentration both increased with exercise testing in the nine patients evaluated. We conclude that the release of atrial natriuretic peptide is at least partly regulated by right and left atrial pressures. Distinguishing the relative contributions of the two atria and defining the role of peptide release in the pathogenesis of heart failure will require further investigation.
CALCULI OF THE PROSTATE
Authors: R. L. Spittel
Journal: BMJ (1915)

CALUCTJI or THE PROSTATE.[x Th;AJUmNA& .289food had been tried only to be-discarded.Of these the m-other professed the poorest opinion.When, how- ever, a tlhird largely advertised food was begun im- provement had been immediate, and of this her praises were loud.An examination of the baby showed that its
Clinical Considerations in Regard to Etiology, Characteristics and Prognosis of Essential Hypertension at Different Ages
Authors: ROBERT S. PALMER, EDWARD G. THORP
Journal: New England Journal of Medicine (1936)

Original Article from The New England Journal of Medicine — Clinical Considerations in Regard to Etiology, Characteristics and Prognosis of Essential Hypertension at Different Ages — A Review of 224 Cases
England plans measures to cut outpatient waits
Authors: P. Anderson
Journal: BMJ (1999)

The Department of Health in England has announced plans to tackle increasing waiting times faced by people attending hospital outpatient clinics.

Recommendations for trusts from the Department of Health and the National Patients' Access team, published last week (at the same time as latest figures showing increased waiting time), included new booking systems for outpatient departments so that patients can choose a date and time convenient for them. The team said that NHS …
CORONARY ARTERY BYPASS GRAFTING WITH AND WITHOUT CONCOMITANT EPICARDIAL CARDIAC RESYNCHRONIZATION THERAPY IN PATIENTS WITH ISCHEMIC HEART FAILURE: LONG-TERM RESULTS: ACC ORAL CONTRIBUTIONS
Authors: Evgeny Pokushalov, Alexander Romanov, Darya Prohorova, Alexander Cherniavskiy
Journal: Journal of the American College of Cardiology (2010)
Vasopressin V1 receptors on the principal cells of the rabbit cortical collecting tubule. Stimulation of cytosolic free calcium and inositol phosphate production via coupling to a pertussis toxin substrate.
Authors: M A Burnatowska-Hledin, W S Spielman
Journal: Journal of Clinical Investigation (1989)

The effects of arginine vasopressin (AVP) on the cytosolic free calcium concentration ([Ca2+]f) were examined in freshly immunodissected rabbit cortical collecting tubule cells using fluorescent Ca2+ indicators fura-2 and indo-1. The addition of AVP to a cell suspension resulted in a rapid and transient increase in the [Ca2+]f. The 1-deamino-8-D-AVP (dDVP), a V2 receptor agonist of AVP that stimulated adenosine 3',5' cAMP production in these cells, had no effect on [Ca2+]f and did not affect AVP-induced increase in [Ca2+]f. The AVP-induced increase in [Ca2+]f but not cAMP production was blocked by the V1 receptor antagonist, [1-(beta-mercapto-beta-beta-cyclopentamethylene propionic acid), 2-(O-methyl)tyrosine] Arg8-vasopressin. The AVP-stimulated increase in [Ca2+]f appeared to be largely due to Ca2+ release from intracellular stores as reduction of extracellular Ca2+ with EGTA had little if any effect on the AVP-induced increase in [Ca2+]f. This AVP-induced increase in [Ca2+]f was associated with an increase in inositol-1,4,5-trisphosphate production and appeared to involve a guanine nucleotide-binding protein (G), since the pretreatment of cells with pertussis toxin for 4-6 h inhibited this effect. Finally, measurements of [Ca2+]f in single cells suggest that only the principal cells of the collecting tubules respond to AVP with an increase in [Ca2+]f. In summary, these results demonstrate that the principal cells of the cortical collecting tubule possess two distinct receptor systems for vasopressin, the well-known V2 receptor coupled to adenylate cyclase, and a V1 receptor system that leads to the mobilization of cytosolic calcium, coupled through a pertussis toxin substrate (G protein) to a production of inositol phosphates.
Autoantibody Signatures in Prostate Cancer
Authors: Xiaoju Wang, Jianjun Yu, Arun Sreekumar, Sooryanarayana Varambally, Ronglai Shen, Donald Giacherio, Rohit Mehra, James E. Montie, Kenneth J. Pienta, Martin G. Sanda, Philip W. Kantoff, Mark A. Rubin, John T. Wei, Debashis Ghosh, Arul M. Chinnaiyan
Journal: New England Journal of Medicine (2005)

New biomarkers, such as autoantibody signatures, may improve the early detection of prostate cancer.With a phage-display library derived from prostate-cancer tissue, we developed and used phage protein microarrays to analyze serum samples from 119 patients with prostate cancer and 138 controls, with the samples equally divided into training and validation sets. A phage-peptide detector that was constructed from the training set was evaluated on an independent validation set of 128 serum samples (60 from patients with prostate cancer and 68 from controls).A 22-phage-peptide detector had 88.2 percent specificity (95 percent confidence interval, 0.78 to 0.95) and 81.6 percent sensitivity (95 percent confidence interval, 0.70 to 0.90) in discriminating between the group with prostate cancer and the control group. This panel of peptides performed better than did prostate-specific antigen (PSA) in distinguishing between the group with prostate cancer and the control group (area under the curve for the autoantibody signature, 0.93; 95 percent confidence interval, 0.88 to 0.97; area under the curve for PSA, 0.80; 95 percent confidence interval, 0.71 to 0.88). Logistic-regression analysis revealed that the phage-peptide panel provided additional discriminative power over PSA (P<0.001). Among the 22 phage peptides used as a detector, 4 were derived from in-frame, named coding sequences. The remaining phage peptides were generated from untranslated sequences.Autoantibodies against peptides derived from prostate-cancer tissue could be used as the basis for a screening test for prostate cancer.
Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors
Authors: Thomas De Raedt, Zandra Walton, Jessica L. Yecies, Danan Li, Yimei Chen, Clare F. Malone, Ophélia Maertens, Seung Min Jeong, Roderick T. Bronson, Valerie Lebleu, Raghu Kalluri, Emmanuel Normant, Marcia C. Haigis, Brendan D. Manning, Kwok-Kin Wong, Kay F. Macleod, Karen Cichowski
Journal: Cancer Cell (2011)
The roles of intrahepatic V?14+ NK1.1+ T cells for liver injury induced bySalmonella infection in mice
Authors: Masatoshi Ishigami, Hitoshi Nishimura, Yoshikazu Naiki, Kentaro Yoshioka, Tetsu Kawano, Yujiro Tanaka, Masaru Taniguchi, Shinichi Kakumu, Yasunobu Yoshika
Journal: Hepatology (1999)

To investigate the roles of intrahepatic T cells in liver injury after Salmonella infection, we examined serum alanine transaminase (ALT), histopathology, and bacterial numbers in liver after infection with Salmonella choleraesuis strain 31N-1 in mice genetically lacking TCRalpha beta+, CD4(+), CD8(+), or NK1.1(+)T cells with C57BL/6 background. In control (+/+) mice, serum ALT reached a peak level by day 7 after an intraperitoneal inoculation of 2 x 10(6) CFU Salmonella choleraesuis 31N-1. In TCR-beta-/- mice, liver injury, as assessed by serum ALT level and histological examination, was significantly suppressed on day 7 after Salmonella infection but the numbers of bacteria in liver did not differ from those in normal mice, suggesting that alpha beta T cells are responsible for liver injury induced by Salmonella infection. To further determine which subsets in alpha beta T cells are important for the liver injury, we compared serum ALT level in mice genetically lacking CD4, CD8, beta2-microglobulin (beta2m, IAbeta, or Jalpha281 after Salmonella infection. In CD4(-/-) mice, serum ALT was significantly lower in comparison with control mice, but there was no difference in serum ALT levels in CD8(-/-) and IAbeta-/- mice from that in control mice. Notably, serum ALT levels and pathological lesions in liver were significantly decreased in beta2m-/- or Jalpha281(-/-) mice, which lacked in NK1.1(+) T cells bearing TCR Valpha14-Jalpha281 specific for beta2m-associated CD1d, following Salmonella infection. Taken together, it is suggested that alpha beta T cells bearing NK1.1 and CD4 may be main effector cells for liver injury after Salmonella infection.
Loss of Taste During Therapy With Penicillamine
Authors: Harry R. Keiser
Journal: JAMA (1968)

A subjective loss of taste for salt and sweet developed in seven of 20 patients with scleroderma or cystinuria during treatment with penicillamine. Determination of taste thresholds confirmed this taste abnormality and, in addition, revealed decreases in taste acuity for sour and bitter. The mechanism of this drug reaction deserves further exploration.
Peanut Anaphylaxis From Food Cross-Contamination-Reply
Authors: Timothy L. Glaros
Journal: JAMA (1996)

In Reply.  —We are very aware that some people have allergic sensitivity to certain food items, even in trace amounts and take extensive safety precautions during our manufacturing process to properly handle ingredients as well as to label packages completely and correctly. Our plants are inspected twice a year to be sure they fully comply with federal good manufacturing practices.  Situations such as the one described here are unusual. Nevertheless, we regret that the problem occurred and apologize to Dr Kemp.
Gastric Acid and Gastrin Response to Decaffeinated Coffee and a Peptone Meal
Authors: Edward J. Feldman
Journal: JAMA (1981)

We compared five graded doses of decaffeinated coffee and a widely used protein test meal (Bacto-peptone) as stimulants of acid secretion (intragastric titration) and gastrin release (radioimmunoassay) in eight healthy men. In each subject, for both acid and gastrin, the sums of the responses to all five doses were greater to decaffeinated coffee than to peptone. The mean +/- SE peak acid output in millimoles per hour was 18.5 +/- 2.9 to decaffeinated coffee and 14.7 +/- 2.7 to peptone, representing 70% and 55%, respectively, of the peak acid output to pentagastrin. The mean +/- SEM peak increment over basal rate in serum gastrin in picograms per milliliter was 84.8 +/- 4.4 to decaffeinated coffee and 44.8 +/- 2.1 to peptone. At equal concentrations, decaffeinated coffee was a more potent stimulant of acid secretion and of gastrin release than peptone. The ingredient(s) of decaffeinated coffee that accounts for its high potency in stimulating acid secretion and gastrin release has not been identified.
Biomechanical implications of mild leg length inequality.
Authors: S T McCaw, B T Bates
Journal: British Journal of Sports Medicine (1991)

The effect of mild leg length inequality (lower extremity length difference less than 3 cm) on posture and gait has been the source of much controversy. Many opinions have been expressed both for and against the need for intervention to reduce the magnitude of the discrepancy. This paper emphasizes the need for accurate and reliable assessment of leg length differences using a clinically functional radiographic technique, and reviews the biomechanical implications of leg length inequality as related to the development of stress fractures, low back pain and osteoarthritis.