tbuckley/cabot-search huggingface dataset:
TCT-169 E-MISAGO – the largest ongoing real life registry of Misago SX nitinol stent in daily use – Clinical Outcome at 1 year
Authors: Johannes Ruef, Stefan Schulte, Kersten Wahl, Karl-Lüdwig Schulte, Johan Duchateau, Ralf-Thorsten Hoffmann, William Taieb, Torsten Fuβ, José Urbano, Luis Bagnaschino Barco, Marian Wierzgoń, Frank Vermassen, Karel Nedved, Dai Do-Do, Ivan Kralj
Journal: Journal of the American College of Cardiology (2012)
Bridging the equity gap in maternal and child health: Health systems research is needed to improve implementation
Authors: øystein E Olsen
Journal: BMJ (2005)

EDITOR—As an adviser to district health managers on priority setting, I am concerned with the constant return to a call for more research on cost effectiveness as the solution to improved implementation of health services in developing countries.1 Cost effectiveness information is useful, but it is far from adequate when a district health manager needs to make a decision and …
Pleural lymphoma in a patient presenting with malabsorption: an illustration of the clinicopathological behaviour in a case of enteropathy associated T cell lymphoma.
Authors: G J Doyel, J D Rose, P J Kesteven
Journal: Gut (1993)

A case of enteropathy associated T cell lymphoma (EATCL) is described, which was diagnosed by biopsy of a lymphomatous pleural mass. Retrospective radiological review showed that this lesion had been present when an initial diagnosis of coeliac disease had been made 12 months previously and a detailed description of the natural history of the lymphoma during this period was thus available. The findings show that EATCL may behave in an indolent fashion and masquerade as coeliac disease, delaying the correct diagnosis. The relation of this disorder with coeliac disease and lymphocytic gastritis is discussed with reference to recent published works.
Case-Related Use of the Medical Literature
Authors: Georgia Scura
Journal: JAMA (1981)

Clinical librarian services provide highly specific, case-related medical literature searches in a manner that permits the information obtained to influence ongoing case management. We have measured the impact of such services on actual case management and on diagnostic thinking in a random sample of 50 searches over five months provided to house officers on medical and pediatric services of a university hospital. Patient management was affected in 20% of cases, and diagnostic thinking was influenced in an even higher percentage of instances. In comparison with information generated by other ancillary services such as clinical laboratories, clinical librarian services appear to be highly effective at an acceptable cost. Since the information generated by such searches may often result in further cost savings to patients, the potential overall efficiency of such services may be great. (<i>JAMA</i>1981;245:50-52)
Warfarin reversal emerging as the major indication for fresh frozen plasma use at a tertiary care hospital
Authors: Bulent Ozgonenel, Barbara O'Malley, Priya Krishen, A.B. Eisenbrey
Journal: American Journal of Hematology (2007)

Because of the increase in the use of warfarin in the population in recent years, reversal of warfarin-related coagulopathy has become common in daily hospital practice. Transfusion of fresh frozen plasma (FFP) is the preferred treatment method for urgent warfarin reversal in the USA. We have undertaken a 1-month audit of FFP usage to ascertain the impact of warfarin use on the consumption of FFP. Sixty percent of the 376 units of FFP that were transfused during the study month were used to reverse warfarin effects. The most common reason to reverse warfarin was bleeding. Thirty-three percent of the units were used for the treatment of other coagulopathies, 7% were used in therapeutic plasmapheresis, and <1% was transfused empirically. One hundred and eighteen patients received FFP during the study month. The study population consisted mostly of elderly patients (65%); however, the warfarin reversing patients consisted disproportionately more of elderly patients (75%) compared with patients receiving FFP for other reasons (46%) (P = 0.0032). Warfarin reversal emerged as the major indication for FFP use in this study. Blood banks of hospitals serving a predominantly elderly patient population should anticipate a higher consumption of FFP. Careful monitoring of warfarin therapy, stringent implementation of the warfarin reversal guidelines, and the introduction of newer products for warfarin reversal would help reduce the consumption of FFP.
Anna Isobel Cupples (nee Pillow)
Authors: B. B Cupples, M. Cupples
Journal: BMJ (2008)

After graduation, Anna Isobel Cupples (nee Pillow) (“Isobel”) worked in Armagh hospitals for two years before marrying Barnett and moving to Belfast to become a minister’s wife. She became involved in general practice, first as a locum and then assistant to facilitate another general practitioner’s involvement in medical politics. On his advice, after moving to Loughbrickland in 1951, …
Chronic hepatitis C (CHC) does not impair the physiologic increase of erythropoietin (EPO) production in response to the ribavirin (RBV)-induced anemia
Authors: Emanuele Durante Mangoni, Luigi Elio Adinolfi, Marie-Francoise Tripodi, Aldo Marrone, Donatella Saviano, Mariagrazia Giordano, Giuseppe Ruggiero
Journal: Journal of Hepatology (2002)
Hypercholesterolemia in Diabetes and Glucose Intolerance in the U.S. Population
Authors: Maureen I Harris
Journal: Diabetes Care (1991)

The prevalence of hypercholesterolemia, according to the guidelines of the National Cholesterol Education Program, has been determined in a national survey of diabetes and glucose intolerance. Rates of elevated total cholesterol in people with diabetes in the United States are only slightly greater than in those without diabetes after adjusting for age and sex. Nevertheless, high or borderline high total cholesterol is common in diabetes and is present in 70% of adults with diagnosed diabetes and 77% with undiagnosed diabetes in the U.S. population. Of these individuals, 95% have evidence of coronary heart disease or two or more risk factors for heart disease and should therefore have their low-density lipoprotein (LDL) cholesterol measured. Based on our national data, LDL cholesterol levels warranting dietary treatment for hypercholesterolemia would be expected in 85% of these people. Although elevated LDL cholesterol is uncommon in people with diabetes who have total cholesterol of &amp;lt;200 mg/dl, other risk factors for coronary heart disease are very frequent (100% of men, 73% of women), and low total and LDL cholesterol may mask low high-density lipoprotein cholesterol. Therefore, investigation of blood lipid levels and coronary heart disease risk factors should be routine in all patients with diabetes, and treatment strategies should include management of lipid disorders and the multiple other risk factors for coronary heart disease that are highly prevalent in these patients.
Recent and emerging anti‐diabetes targets
Authors: Michael L. Mohler, Yali He, Zhongzhi Wu, Dong Jin Hwang, Duane D. Miller
Journal: Medicinal Research Reviews (2008)

Abstract Diabetes is a disease that affects over 150 million people worldwide for which there are multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, diabetes rates in both developed and developing countries are increasing at an alarming rate. Current medications are not adequately effective in maintaining long‐term glycemic control in most patients, even when used in combination, leaving diabetics susceptible to developing life threatening and debilitating complications such as cardiovascular disease, blindness, kidney complications, and amputations. Consequently, there is a critical need for more potent pharmacotherapies with novel mechanisms of action. A panel of 20 emerging diabetes targets is presented, and small molecule modulators for each target will be discussed. © 2008 Wiley Periodicals, Inc. Med Res Rev, 29, No. 1, 125–195, 2009
Staphylococcal Nasal Carriage and Wound Sepsis in Relation to ABO and Rh Blood Groups of Male Surgical Patients
Authors: H. White, R. A. Shooter
Journal: BMJ (1962)

an extreme example of its kind.An alternative explanation might be that thalidomide has a blocking effect upon one or more of the adrenal cortical enzymes concerned with cortisol synthesis.The raised urinary 17-hydroxycorticoid excretion would then result from an attempt by the pituitary-adrenal axis to compensate for the deficiency of cortisol, as happens in some forms of congenital adrenal hyperplasia, or after giving the adrenal inhibitor 2-methyl-l,2-bis-(3-pyridyl)-l-propan- one (" metopirone " SU 4885).The relatively low output of I I-oxy-17-hydroxycorticoids, the slightly raised pregnanetriol excretion, and the high urinary sodium/potassium ratios lend some support to this alternative.The hypoglycaemia would, on this basis, arise from a deficiency of glucocorticoids such as cortisol.Hypoglycaemia is known to occur in some forms of congenital adrenal hyperplasia and "meto- pirone" has been reported as lowering the fasting blood sugar (Fukushima et al., 1960).Whatever the causative mechanism, this effect of thalidomide upon the adrenal glands may be of importance in our understanding of the origin of the foetal abnormalities associated with the drug.It may perhaps be of relevance also to the reversible amenorrhoea that has been associated with the administration of thalidomide (Howe, 1961).We should therefore like to draw the attention of those engaged in this field to our findings.
The Last Word on Using Grids
Authors: A. Marshall Smith
Journal: Annals of Internal Medicine (1994)

Letters15 February 1994The Last Word on Using GridsA. Marshall Smith, MDA. Marshall Smith, MD336 Mount Hope Avenue; Bangor, ME; 04401-4298Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-4-199402150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the letter titled “Using Grids to Document Laboratory Results” [1]. I also have encountered difficulty in determining the laboratory results indicated by some residents, but I have not been able to influence their use of grids. To avoid confusion, I have adopted the habit of writing down the name of the test next to the value of interest. This approach does not require a great deal of extra time and eliminates the possibility of confusion. The various codes are not true short cuts and serve only to add confusion and the risk for ...REFERENCE1. Spaulding A, Silverblatt FJ. Using grids to document laboratory results (Letter). Ann Intern Med. 1993; 119:863. Google Scholar Author, Article, and Disclosure InformationAuthors: A. Marshall Smith, MDAffiliations: 336 Mount Hope Avenue; Bangor, ME; 04401-4298 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1994Volume 120, Issue 4Page: 347KeywordsHabitsPhysiotherapyProthrombin timeResearch laboratories ePublished: 15 August 2000 Issue Published: 15 February 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Lung Cancer and the Debrisoquine Metabolic Phenotype
Authors: N. E. Caporaso, M. A. Tucker, R. N. Hoover, R. B. Hayes, L. W. Pickle, H. J. Issaq, G. M. Muschik, L. Green-Gallo, D. Buivys, S. Aisner, J. H. Resau, B. F. Trump, D. Tollerud, A. Weston, C. C. Harris
Journal: JNCI Journal of the National Cancer Institute (1990)

In a case-control study, we tested the hypothesis that the genetically determined ability to metabolize debrisoquine is related to risk of lung cancer. Overall, individuals who were extensive metabolizers of debrisoquine were at significantly greater risk of lung cancer than those who were poor or intermediate metabolizers (odds ratio = 6.1; 95% confidence interval = 2.2–17.1). In this study, case patients had lung cancer, and control subjects had either chronic obstructive c pulmonary disease or cancers other than lung cancer. Results were adjusted for age, race, asbestos exposure, and smoking. Both black and white individuals who were extensive metab-olizers of debrisoquine were at significantly increased risk after similar adjustment (for blacks, odds ratio =4.5, 95% c confidence interval = 1.1–18.1; for whites, odds ratio =10.2, 95% confidence interval = 2.0–51.4). Significantly increased risk of lung cancer was also present for individuals who were extensive metabolizers when subjects with chronic obstruc- tive pulmonary disease or other cancers were considered separately. These data confirm that the ability to metabolize debrisoquine is a major determinant of susceptibility to lung cancer. Evaluation of the marker in other case-control I settings, further exploration of racial differences, and the prospective evaluation of this marker in subgroups at high risk of lung cancer are areas worthy of further study. [J Natl Cancer Inst 82: 1264–1272, 1990]
The undescended testicle: a continuing failure.
Authors: H Reece-Smith, C U Moisey
Journal: BMJ (1984)

Numbers and motility of sperms before and during treatment with balsalazide Sperm count ( x 109/l) Sperm motility (Os) (normal >30 x 109/l) (normal >500o)After (months of After (months of treatment): treatment): Initi-Initi-Case Age ally ally
Urinary Catheter Use Often “Inappropriate” in Hospitalized Elderly Patients
Authors: Tracy Hampton
Journal: JAMA (2006)

About 1 of 4 urinary catheters implanted in hospitalized patients aged 70 years or older and 1 of 3 in hospitalized patients aged 85 years or older are unnecessary, according to a new study (Holroyd-Leduc JM et al. J Patient Saf. 2005;1:201-207).
Copper vapour laser (578 nm) and flashlamp-pumped pulsed tunable dye laser (585 nm) treatment of port wine stains: results of a comparative study using test sites
Authors: R.A. SHEEHAN-DARE, J.A. COTTERILL
Journal: British Journal of Dermatology (1994)

Journal Article Copper vapour laser (578 nm) and flashlamp‐pumped pulsed tunable dye laser (585 nm) treatment of port wine stains: results of a comparative study using test sites Get access R.A. SHEEHAN‐DARE, R.A. SHEEHAN‐DARE Department of Dermatology, The General Infirmary, Great George Street, Leeds LS1 3EX, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.A. COTTERILL J.A. COTTERILL Department of Dermatology, The General Infirmary, Great George Street, Leeds LS1 3EX, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue 4, 1 April 1994, Pages 478–482, https://doi.org/10.1111/j.1365-2133.1994.tb03381.x Published: 01 April 1994 Article history Accepted: 23 August 1993 Published: 01 April 1994
A Prospective Study of Dairy Intake and the Risk of Type 2 Diabetes in Women
Authors: Simin Liu, Hyon K. Choi, Earl Ford, Yiqing Song, Anna Klevak, Julie E. Buring, JoAnn E. Manson
Journal: Diabetes Care (2006)

Although studies have indicated that increased dairy intake may reduce risk of overweight and insulin resistance syndrome, data directly relating dairy intake to type 2 diabetes remain sparse.We prospectively examined the associations between intake of dairy foods and calcium and incident type 2 diabetes in 37,183 women without a history of diabetes, cardiovascular disease, and/or cancer at baseline.During an average of 10 years of follow-up, we documented 1,603 incident cases. After adjusting for potential confounders including BMI, smoking status, physical activity, family history of diabetes, alcohol consumption, history of hypertension, use of hormones, and high cholesterol, the relative risk for type 2 diabetes among women in the highest quintile of dairy intake was 0.79 (95% CI 0.67-0.94; P for trend = 0.007) compared with those in the lowest quintile. Each serving-per-day increase in dairy intake was associated with a 4% lower risk (0.96 [0.93-1.01]). The inverse association with type 2 diabetes appeared to be mainly attributed to low-fat dairy intake; the multivariate relative risks comparing the highest to the lowest quintiles was 0.79 (0.67-0.93; P for trend = 0.002) for low-fat dairy. The inverse relation between dairy intake and incident type 2 diabetes remained unchanged after further adjustment for dietary calcium, vitamin D, glycemic load, fat, fiber, and magnesium intake. These associations also did not vary significantly according to BMI.A dietary pattern that incorporates higher low-fat dairy products may lower the risk of type 2 diabetes in middle-aged or older women.
Systemic Treatment of Severe Psoriasis
Authors: Nicholas J. Lowe
Journal: New England Journal of Medicine (1991)

The pathogenesis of psoriasis, which affects approximately 2 percent of the population of the United States and Northern Europe, remains obscure. It is recognized that the disease is genetically determined, but the precise mode of inheritance has not been defined.Psoriasis is most commonly of the plaque type, manifested by disfiguring erythematous scaling plaques that frequently localize on the extensor aspects of the body, especially the knees and elbows, and on the scalp. It can, however, become more extensive and occasionally affect entire areas of the body, and is then called erythrodermic or exfoliative psoriasis. Patients with extensive disease are . . .
Dutch are tallest in the world
Authors: T. Sheldon
Journal: BMJ (1998)

Young Dutch people are the tallest in the world and getting taller, according to the Netherlands fourth national growth study, which measured 20000 young people aged under 21 during 1997.

Since 1980, boys have continued to get taller, by on average 20 mm (with an average height of 1.84 m) and girls by 23 mm (nearly 1.71 m), says the study, carried out by TNO Prevention and Health (part of the Dutch organisation for applied scientific research) and …
Lifestyle Intervention Is Associated With Lower Prevalence of Urinary Incontinence
Authors: Jeanette S. Brown, Rena Wing, Elizabeth Barrett-Connor, Leroy M. Nyberg, John W. Kusek, Trevor J. Orchard, Yong Ma, Eric Vittinghoff, Alka M. Kanaya
Journal: Diabetes Care (2006)

OBJECTIVE—Diabetes is associated with increased urinary incontinence risk. Weight loss improves incontinence, but exercise may worsen this condition. We examined whether an intensive lifestyle intervention or metformin therapy among overweight pre-diabetic women was associated with a lower prevalence of incontinence. RESEARCH DESIGN AND METHODS—We analyzed data from the Diabetes Prevention Program, a randomized controlled trial in 27 U.S. centers. Of the 1,957 women included in this analysis, 660 (34%) were randomized to intensive lifestyle therapy, 636 (32%) to metformin, and 661 (34%) to placebo with standard lifestyle advice. The main outcome measure was incontinence symptoms by frequency and type by a validated questionnaire completed at the end-of-trial visit (mean 2.9 years). RESULTS—The prevalence of total (stress or urge) weekly incontinence was lower among women in the intensive lifestyle group (38.3%) than those randomized to metformin (48.1%) or placebo (45.7%). This difference was most apparent among women with stress incontinence (31.3% for intensive lifestyle group vs. 39.7% for metformin vs. 36.7% for placebo, P = 0.006). Changes in weight accounted for most of the protective effect of the intensive lifestyle intervention on stress incontinence. CONCLUSIONS—Less-frequent urinary incontinence may be a powerful motivator for women to choose lifestyle modification to prevent diabetes.
Assisted conception. III--Problems with assisted conception
Authors: P. Braude
Journal: BMJ (2003)

Problems associated with assisted conception can be clinical, ethical, or psychological. This article covers medical problems (such as ovarian hyperstimulation syndrome (OHSS) and ectopic pregnancy), ethical questions that arise from situations such as the creation of surplus embryos, and difficult decisions that have to be made, such as when to advise a couple to stop treatment.

View this table:

Presentation of OHSS



OHSS is arguably the most serious risk of treatment with gonadotrophins. It is not clear why OHSS occurs, although it is particularly severe with the use of gonadotrophin releasing hormone analogues and polycystic ovary syndrome. It generally develops if the patient has had an excessive response to gonadotrophins and has produced a large number (20 or more) follicles with its associatedexcessive rise in oestrogen production. OHSS occurs after exogenous human chorionic gonadotrophin has been administered, or when human chorionic gonadotrophin rises endogenously after a treatment cycle has been successful and an embryo has implanted.

OHSS presents with substantial enlargement of the ovaries, which are filled with enlarging follicles (despite drainage at the time of egg collection) causing abdominal pain, distension, and extravascular fluid extravasation, which results in ascites and haemoconcentration. In the severest OHSS pleural effusions may develop and arterial or venous thromboses can occur because of hypercoagulability.

View this table:

Management of OHSS



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Ultrasound scan showing an enlarged ovary (10 cm x 6 cm) and fluid in the pouch of Douglas and the uterovesical pouch

Superovulation regimens should be designed and monitored to minimise OHSS. However, because of its idiosyncratic nature, the syndrome cannot be avoided completely. Indeed, it can occur simply by using clomifene to induce ovulation in sensitive patients, such as those with polycystic ovary syndrome. OHSS should be managed in a specialist hospital, preferably one with an in vitro fertilisation unit, where there will be the appropriate expertise to deal …

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Incidence of Type I Diabetes in People Under 30 Years of Age in Barbados, West Indies, 1982-1991
Authors: Oscar W Jordan, Rebecca B Lipton, Elzbieta Stupnicka, J Kennedy Cruickshank, Henry S Fraser
Journal: Diabetes Care (1994)

To determine the incidence of type I diabetes among individuals < 30 years of age on the island of Barbados in the Caribbean. The population is predominantly African in origin but exhibits a relatively westernized lifestyle.