tbuckley/cabot-search huggingface dataset:
Bence Jones Proteins: Malignant or Benign?
Authors: Alan Solomon
Journal: New England Journal of Medicine (1982)

Over a century elapsed between Henry Bence Jones' discovery of a urinary protein with unusual thermal properties in patients with multiple myeloma1 and Edelman and Gally's demonstration2 that this curious protein was the light polypeptide portion (kappa or lambda chain) of the immunoglobulin molecule. It is now known that normal urine contains very small amounts of a mixture of free kappa and lambda light chains of polyclonal origin, but Bence Jones proteinuria denotes the presence of a monoclonal light chain of either the kappa or the lambda type.Bence Jones proteins, far from being a laboratory curiosity, are historically among . . .
Iodine 123-phenylpentadecanoic acid myocardial scintigraphy: usefulness in the identification of myocardial ischemia.
Authors: P L Kennedy, J R Corbett, P V Kulkarni, C L Wolfe, D E Jansen, C L Hansen, L M Buja, R W Parkey, J T Willerson
Journal: Circulation (1986)

In this study, we tested the hypothesis that myocardial ischemia induced by exercise in patients is associated with diminished metabolism and/or delayed clearance of an intravenously injected fatty acid, iodine 123-labeled phenylpentadecanoic acid (IPPA). Fifteen normal volunteers and 18 patients with significant coronary heart disease (CHD) received IPPA during exercise. In the patients with CHD, radionuclide ventriculograms were also obtained during exercise. The normal volunteers had relatively uniform initial left ventricular segmental IPPA activity after exercise and uniform IPPA clearance in the interval from 4 to 20 min immediately after exercise. In contrast, the patients with CHD had increased initial left ventricular segmental IPPA activity (63%, p less than .001) and delayed IPPA clearance (44%, p less than .01) in segments supplied by significantly narrowed coronary arteries. Based on analysis with the mean values +/- 1 SD for initial IPPA activity, clearance, or both in normal volunteers, the sensitivity and specificity of exercise IPPA scintigraphy for detecting CHD were 89% and 67%, respectively; when +/- 2 SD differences from the mean values in the normal volunteers were considered, the sensitivity and specificity were 72% and 100%, respectively. Among the total of 27 noninfarcted left ventricular segments supplied by significantly narrowed coronary arteries in the study patients, 26 (96%) had an abnormality (mean +/- 1 SD) of either initial IPPA activity or clearance compared with corresponding segments in the normal volunteers and/or with other left ventricular segments in the same image that were not supplied by significantly narrowed coronary arteries.(ABSTRACT TRUNCATED AT 250 WORDS)
Inhibition by leukocyte depletion of neointima formation after balloon angioplasty in a rabbit model of restenosis
Authors: Ashley M. Miller, Allan R. McPhaden, Roger M. Wadsworth, Cherry L. Wainwright
Journal: Cardiovascular Research (2001)

The aim of the current study was to examine neointima formation in balloon injured left subclavian artery of rabbits subjected to two different methods of leukocyte depletion at the time of injury.Angioplasty of the left subclavian artery was performed in leukopenic male New Zealand White rabbits. Depletion of circulating leukocytes was induced by either mustine hydrochloride or an antibody against leukocyte common antigen (anti-LCA) before angioplasty. Left and right subclavian arteries were removed 28 days after injury for morphological analysis and measurement of neointimal size. At the same time, leukocytes were isolated from autologous rabbit blood for 51Cr-labelling for assessment of leukocyte adhesion to injured and non-injured artery segments.Leukopenia decreased neointima formation in injured arteries (neointimal area was 0.09+/-0.03 mm(2) in mustine-treated arteries, n=8, vs. 0.56+/-0.07 mm(2) in control arteries, n=7; P<0.001 and 0.07+/-0.01 mm(2) in anti-LCA treated arteries, n=9, vs. 0.22+/-0.04 mm(2) in non immune serum-treated arteries, n=9; P<0.001). Adventitial fibrosis was also significantly (P<0.05) decreased by both leukopenic interventions. Neither medial nor adventitial area was modified in any of the groups. No differences in leukocyte adhesion were observed between injured and non-injured arteries in any of the experimental groups at the 28 day time point.These results suggest that leukocytes play a major role in the development of two of the major characteristics of the response to balloon injury, namely formation of neointima and adventitial fibrosis, that currently limit the success of clinical angioplasty. Elucidation of the fine mechanisms involved in leukocyte-mediated injury may lead to the discovery of novel therapeutic targets for the prevention of restenosis.
Doing with development: Moving toward a complete theory of concepts
Authors: Haley A. Vlach, Lauren Krogh, Emily E. Thom, Catherine M. Sandhofer
Journal: Behavioral and Brain Sciences (2010)

Abstract Machery proposes that the construct of “concept” detracts from research progress. However, ignoring development also detracts from research progress. Developmental research has advanced our understanding of how concepts are acquired and thus is essential to a complete theory. We propose a framework that both accounts for development and holds great promise as a new direction for thinking about concepts.
The Stress Response to Laparoscopic Cholecystectomy: Investigation of Endocrine Parameters
Authors: U. Deuss, J. Dietrich, D. Kaulen, K. Frey, W. Spangenberger, B. Allolio, M. Matuszczak, H. Troidl, W. Winkelmann
Journal: Endoscopy (1994)

Laparoscopic cholecystectomy, as a typical example of minimal invasive surgery, is associated with low complication rates and minimal patient discomfort, and provides the same safety as conventional cholecystectomy. In the present prospective observational study, endocrine parameters as indicators for stress response were measured. We investigated 53 patients with laparoscopy cholecystectomy and 12 patients with conventional cholecystectomy. Blood samples were taken pre-, peri-, and postoperatively for measurement of ACTH, cortisol, prolactin, and growth hormone, General anesthesia followed as standardized protocol. The increase in all stress hormones die not differ between patients in the two groups, and was comparable with that reported in the literature and the findings of our own previous studies in patients undergoing conventional cholecystectomy and elective colon resection. We conclude that laparoscopic cholecystectomy is associated with a pronounced endocrine stress response that does not account for the observed difference in the peri- and postoperative complication rate or patient comfort.
A piece of my mind. A doctor in her house
Authors: B. Z. Paulshock
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The tooth fairy and malpractice
Authors: S. Ludman, H. Daya, P. S. Richards, A. Fox
Journal: BMJ (2012)

We are concerned that the actions of the mythical character at the root of this report must be brought to the attention of the medical community, as it seems to represent the first signs of a worrying new trend in malpractice.1 2 Previous anecdotal evidence suggests the tooth fairy is benevolent, but this opinion may need revising in light of mounting reports of less child-friendly activity.

An 8 year old boy was referred to a specialist allergy clinic with a history of profuse mucopurulent rhinorrhoea. After a failure of first line medical treatment, computed tomography of the sinuses was …
Interventional genetics and cancer treatment.
Authors: D J Evans
Journal: BMJ (1993)

Specific health advice continues to be incon- sistent, ranging from the mention of just one disease to tabular information.Some of the in- correct information given at best could give travellers a false sense of security and at worst could result in their risking a preventable infection.Clearly, the travel trade continues to rely on the availability of other sources of information, with most brochures carrying only general advice and 50 of the remaining 56 recommending that further advice should be taken.The number of brochures (58) that recommended that travellers should seek additional information from their general practitioner seems inappropriately low, considering that general practitioners have shown enthusiasm for providing advice5 and are ideally placed to do so, having knowledge of the traveller's lifestyle, immunisation history, and relevant medical history such as allergies and of the side effects of vaccines5 as well as ready access to computerised database information on this subject.
Study of eight cases of cancer in 426 rheumatoid arthritis patients treated with methotrexate
Authors: C. Bologna, M.-C. Picot, C. Jorgensen, P. Viu, R. Verdier, J. Sany
Journal: Annals of the Rheumatic Diseases (1997)

<h3>OBJECTIVE</h3> To report cancer cases in 426 rheumatoid arthritis patients treated with methotrexate, and determine whether there was an increased incidence of cancer compared with patients never treated with methotrexate (rheumatoid controls) and to the whole regional population. <h3>METHODS</h3> The duration of methotrexate treatment was 37.4 (SD 27.9) months. This population was compared with 420 rheumatoid arthritis controls and with a regional population of 812 344 people. Life table analysis was performed to compare the cancer incidence in the two rheumatoid populations. Adjustment for potentially confounding factors was done. The indirect standardisation method was used to compare each rheumatoid population with the regional population. <h3>RESULTS</h3> Eight cases of cancer (1.88%; 4.04 cases/1000 person years) were diagnosed in the methotrexate population <i>v </i>six (1.43%; 58.8 cases/1000 person years) in the rheumatoid controls. The life table method showed a higher incidence of cancer in the rheumatoid controls (P = 0.0001). In a multivariate analysis (Cox model), the only significant factor explaining this difference in the cancer incidence was age (P = 0.02). In the regional population there were 6418 new cases of cancer (0.79%; 2.85 cases/1000 person years). By the indirect standardisation method, the ratio of observed cases to expected cases of cancer in each of the rheumatoid populations was not significantly different from 1. <h3>CONCLUSIONS</h3> In these eight cases, methotrexate was not found to be responsible for generating cancers. However, because of data regarding lymphomas and methotrexate, and because of the short follow up, especially in the control group, longer prospective studies are warranted.
Treatment of High Blood Pressure
Authors: Sanford Cobb
Journal: JAMA (1977)

To the Editor.—  We have recently read Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure, (237:255, 1977). The report as a whole is a commendable document, but it contains a number of scientific errors and omissions. The following suggestions are provided to reduce possible hazard to certain patients and to allow greater therapeutic efficacy on many occasions.  In Step 1 of the Stepped-Care Approach section, the important therapeutic consideration that secondary hyperaldosteronism may lessen efficacy has not been mentioned. A concluding comment could be added to this section in a future edition of the report, to read as follows:  The volume depletion produced by thiazide therapy may cause increased secretion of aldosterone, resulting in fluid and sodium retention and a lesser reduction in blood pressure. When secondary hyperaldosteronism is suspected of blunting antihypertensive efficacy in Step 1, the physician should consider adding an
354 REGULATORY T CELLS INVOLVED IN IMMUNOPATHOGENESIS FROM CHRONIC HEPATITIS B PROGRESSED TO HEPATOCELLULAR CARCINOMA
Authors: H.H. Zhang, M.H. Mei, R. Fei, F. Liu, J.H. Wang, W.J. Liao, L.L. Qin, L. Wei, H.S. Chen
Journal: Journal of Hepatology (2008)
Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.
Authors: Q Li, B Li, X Wang, A Leri, K P Jana, Y Liu, J Kajstura, R Baserga, P Anversa
Journal: Journal of Clinical Investigation (1997)

To determine whether IGF-1 opposes the stimulation of myocyte death in the surviving myocardium after infarction, transgenic mice overexpressing human IGF-1B in myocytes (FVB.Igf+/-) and wild-type littermates at 1.5 and 2.5 mo of age were subjected to coronary ligation and killed 7 d later. Myocardial infarction involved an average 50% of the left ventricle, and produced cardiac failure. In the region proximate to infarction, myocyte apoptosis increased 4. 2-fold and 2.1-fold in nontransgenics at 1.5 and 2.5 mo, respectively. Corresponding increases in myocyte necrosis were 1. 8-fold and 1.6-fold. In contrast, apoptotic and necrotic myocyte death did not increase in FVB.Igf+/- mice at either age after infarction. In 2.5-mo-old infarcted nontransgenics, functional impairment was associated with a 29% decrease in wall thickness, 43% increase in chamber diameter, and a 131% expansion in chamber volume. Conversely, the changes in wall thickness, chamber diameter, and cavitary volume were 41, 58, and 48% smaller in infarcted FVB.Igf+/- than in nontransgenics. The differential response to infarction of FVB.Igf+/- mice resulted in an attenuated increase in diastolic wall stress, cardiac weight, and left and right ventricular weight-to-body wt ratios. In conclusion, constitutive overexpression of IGF-1 prevented activation of cell death in the viable myocardium after infarction, limiting ventricular dilation, myocardial loading, and cardiac hypertrophy.
The Safety of Trekking at High Altitude After Coronary Bypass Surgery-Reply
Authors: John B. West
Journal: JAMA (1988)

<h3>In Reply.—</h3> Dr Hultgren raises some interesting points. However, I stand by our original contention that a patient who has had coronary bypass surgery would undergo some risk by trekking to an altitude of 5760 m (19 008 ft). There is overwhelming evidence of severe arterial hypoxemia at this great altitude irrespective of whether the trekker is well-acclimatized. For example, when a group of physiologists lived at a similar altitude of 5800 m (19 140 ft) for several months during the Himalayan Scientific and Mountaineering Expedition of 1960 to 1961, the mean arterial oxygen saturation was only 67% at rest and fell further during exercise.<sup>1</sup>The calculated resting arterial oxygen partial pressure (PO<sub>2</sub>) was only 36 mm Hg. Such a low arterial PO<sub>2</sub>must cause severe tissue hypoxia. Although the 51-year-old patient had a coronary artery bypass with apparently excellent results, it is unreasonable to assume that
Amantadine for Influenza
Authors: Jonathan M. Mann
Journal: JAMA (1977)

To the Editor.—  A recent article by Drs Jackson and Stanley (235:2739, 1976) on the chemoprophylaxis of influenza concluded, There is a role for the further development of chemoprophylaxis and chemotherapy for influenza that deserves attention and support. The major currently available chemoprophylactic agent for influenza A virus is amantadine, which is labeled for prophylaxis of A2 influenza (201:114, 1967). Since amantadine has only been available for clinical and epidemiologic study in the era of the A2 influenza viruses, its use against a substantially different type A influenza virus, such as the swine flu virus (A/New Jersey/ 76; Hsw1N1), is untested.  Nevertheless, there is data to support the suggestion that amantadine could be equally effective against swine flu virus as against A2 influenza. In tissue culture, amantadine was found to inhibit the multiplication of several influenza A viruses (A/PR/8 [HON1]; A/Fort Meyers [H1N1]) but was without effect against influenza B
John ("Jake") Stohlner
Authors: B. Scaife
Journal: BMJ (2002)

Former general practitioner Stockton-on-Tees (b 1921; q St Andrews 1943; DRCOG), died from pneumonia on 13 February 2002.

Upon qualification Jake joined the army and saw action in north Africa and Italy. After demobilisation he returned to Dundee to train in obstetrics, but decided on a career change and in the early 1950s joined a practice in Stockton-on-Tees, with obstetrics as his forte. He was also a police surgeon and medical officer to an engineering firm. In 1972 he joined three other practices in forming a group practice. He retired in 1985. Jake's abiding interest was music. He had an encyclopaedic knowledge of opera and a love of Mahler's symphonies. He leaves a wife, Doreen; and three children.
Gaspare Tagliacozzi--plastic surgeon
Authors: J. P. Webster
Journal: JAMA (1969)

To  Editor:—  One sentence in  editorial which might have been more understandingly presented was  statement ( 207 :1343, 1969), Although Tagliacozzi mentions  possibility of heterologous skin transplants, he found it more practical to select  skin from  patient's own body. If, after practical ,  words because of  difficulty in keeping two individuals attached to each other for  requisite length of time were inserted, this would have given  reason more clearly. Tagliacozzi explains this in book 1, chapter 18, page 59 of his De curtorum chirurgia per insitionem (concerning  surgery of deformities by transplantation), Venice, 1597.  In  final paragraph of  editorial, a quotation said to be taken from the first chapter of Tagliacozzi's treatise, really appears in  epilogue of Mrs. Gnudi's and my book, The Life and Times of Gaspare Tagliacozzi, Surgeon of Bologna, 1545-1599 , page 331, first paragraph, which
Turning a blind eye:Testing the success of blinding and the CONSORT statement
Authors: Douglas G Altman, Kenneth F Schulz, David Moher
Journal: BMJ (2004)

EDITOR—Reports of randomised trials should state clearly whether blinding was attempted, and if so who was blinded and how this was done.1 Fergusson et al note that blinding may be ineffective in some trials, making them less sound methodologically than they seem to be.2

But trial participants asked to …
Hyaluronan in cervical epithelia protects against infection-mediated preterm birth
Authors: Yucel Akgul, R. Ann Word, Laura M. Ensign, Yu Yamaguchi, John Lydon, Justin Hanes, Mala Mahendroo
Journal: Journal of Clinical Investigation (2014)

Increased synthesis of cervical hyaluronan (HA) from early to late pregnancy has long been proposed to play an essential role in disorganization of the collagen-rich extracellular matrix to allow for maximal compliance and dilation of the cervix during the birth process. Here, we show that HA is not essential for increased cervical distensibility during late pregnancy. Rather, cervicovaginal HA plays an unanticipated important role in epithelial barrier protection of the lower reproductive tract. Specifically, HA depletion in the cervix and vagina resulted in inappropriate differentiation of epithelial cells, increased epithelial and mucosal permeability, and strikingly increased preterm birth rates in a mouse model of ascending vaginal infection. Collectively, these findings revealed that although HA is not obligatory for cervical compliance, it is crucial for maintaining an epithelial and mucosal barrier to limit pathogen infiltration of the lower reproductive tract during pregnancy and thereby is protective against infection-mediated preterm birth.
The Missing Macroglobulin
Authors: Christine Lawrence
Journal: Annals of Internal Medicine (1993)

Letters1 November 1993The Missing MacroglobulinChristine Lawrence, MD and Joseph Furgiuele, MDChristine Lawrence, MDSearch for more papers by this author and Joseph Furgiuele, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-9-199311010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail We recently had a patient with Waldenstrom macroglobulinemia whose diagnosis was delayed because the automated blood analyzer did not detect the macroglobulin.A 49-year-old man had experienced epistaxis, dyspnea, and weakness for several months. His sclerae were icteric and pale, and he had retinal hemorrhages as well as marked tortuosity and dilatation of the retinal veins. The liver and spleen were not palpable and he had no peripheral lymphadenopathy.A peripheral smear showed marked erythrocyte rouleaux and plasmacytoid lymphocytes. Serum protein electrophoresis showed a striking spike Figure 1, and immunofixation electrophoresis showed a monoclonal IgM- . His bone marrow was ...REFERENCE1. Waldenstrom J. Incipient myelomatosis or essential hyperglobulinemia with fibrinogenopeniaa new syndrome? Acta Medica Scandinavia. 1944; 117:216-38. Google Scholar Author, Article, and Disclosure InformationAuthors: Christine Lawrence, MD; Joseph Furgiuele, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1993Volume 119, Issue 9Page: 954KeywordsAttentionHemorrhageLiverLymphocytesProteinsResearch laboratoriesSaline solutionsSerum proteinsSpleenVeins ePublished: 15 August 2000 Issue Published: 1 November 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PEGylated NaLuF4: Yb/Er upconversion nanophosphors for in vivo synergistic fluorescence/X-ray bioimaging and long-lasting, real-time tracking
Authors: Zhigao Yi, Wei Lu, Yaru Xu, Jing Yang, Li Deng, Chao Qian, Tianmei Zeng, Haibo Wang, Ling Rao, Hongrong Liu, Songjun Zeng
Journal: Biomaterials (2014)
Mercury Poisoning in Infancy
Authors: B. Egan, B. McNicholl
Journal: BMJ (1966)

perforated segment (two cases), colostomy only (three cases), and drainage only (one case).The total hospital stay of these 15 cases amounted to 1,138 days, with an average of 11 weeks per patient.In order to reduce the high mortality (30 to 40% in the larger reported series4 5) and morbidity, I should like to suggest that perforated diverticulitis should be treated by primary resection (Paul-Mikulicz's, Hart- mann's, or preferably with immediate anastomosis).If it is possible to perform only proximal colostomy initially, and the patient survives, there may be a place for subsequent sigmoid colomyotomy' rather than resection, especially in poor-risk patients.Early mortality in perforated diverticulitis is usually due to endotoxin shock as a result of peritonitis.These desperately ill patients should be treated energetically with anti- biotics, massive infusions of plasm expanders, oxygen, and /3-adrenergic blocking agents.7-Iam, etc.,