Rhinocerebral Phycomycosis in Association with Diabetic Ketoacidosis
Authors: EUGENE ABRAMSON
Journal: Annals of Internal Medicine (1967)

Case Studies1 April 1967Rhinocerebral Phycomycosis in Association with Diabetic KetoacidosisReport of Two Cases and a Review of Clinical and Experimental Experience with Amphotericin B TherapyEUGENE ABRAMSON, M.D., DANA WILSON, M.D., RONALD A. ARKY, M.D.EUGENE ABRAMSON, M.D., DANA WILSON, M.D., RONALD A. ARKY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-4-735 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhycomycosis is the most acutely fatal fungal disease known (1). Not described in this country until 1943 (2), its prevalence appears to be increasing, concurrently with and perhaps related to the rising rate of antibiotic use. Before the mid-1950's the prognosis was considered "hopeless" (3). Since the introduction of amphotericin B, considerable evidence of its effectiveness in such fungal infections as blastomycosis and cryptococcosis has accrued. Published reports of its use in phycomycosis are few, however. We have recently followed two cases of rhinocerebral phycomycosis arising in association with diabetic ketoacidosis and treated with amphotericin B. This paper presents further...References1. BAKER RD: Resectable mycotic lesions and acutely fatal mycoses. JAMA 150: 1579, 1952. CrossrefMedlineGoogle Scholar2. GREGORYGOLDENHAYMAKER JEAW: Mucormycosis of the central nervous system. Bull. Hopkins Hosp. 73: 405, 1943. Google Scholar3. CONANT NF: Manual of Clinical Mycology, 2nd ed. W. B. Saunders Co., Philadelphia, 1954, p. 213. Google Scholar4. TAYLORSHKLARBUDSONHACKETT RGRR: Mucormycosis of the oral mucosa. Arch. Derm. (Chicago) 89: 419, 1964. CrossrefMedlineGoogle Scholar5. SMITHKIRCHNER HWJA: Cerebral mucormycosis. Arch. Otolaryng. (Chicago) 68: 715, 1958. CrossrefGoogle Scholar6. MCBRIDECORSONDAMMIN RAJMGJ: Mucormycosis. Two cases of disseminated disease with cultural identification of rhizopus; review of literature. Amer. 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J. Amer. Vet. Med. Ass. 144: 399, 1964. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Thorndike Memorial Laboratory and the Second and Fourth (Harvard) Medical Services and the Diabetes Clinic, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Mass.This work was supported by research grant A-1571 and training grant 2-A-5060, the National Institute of Arthritis and Metabolic Diseases, and by grant FR-76, the Division of Research Facilities and Resources, National Institutes of Health, Bethesda, Md.Dr. Arky is the recipient of the Elliot P. Joslin Research and Development Award of the American Diabetes Association, New York, N. Y.Requests for reprints should be addressed to Ronald A. Arky, M.D., Thorndike Memorial Laboratory, Boston City Hospital, Boston, Mass. 02118. 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Antifungal Agents 1 April 1967Volume 66, Issue 4Page: 735-742KeywordsAmphotericinCryptococcosisDrug therapyFungal diseasesHospital medicineMedical servicesMetabolic disordersResearch facilitiesResearch grantsResearch laboratories Issue Published: 1 April 1967 PDF DownloadLoading ...