Graves Disease after Bone Marrow Transplantation
Authors: Akihiro Takeshita, Kaori Shinjo, Rynzo Ohno
Journal: Annals of Internal Medicine (1999)

Letters20 July 1999Graves Disease after Bone Marrow TransplantationAkihiro Takeshita, MD, Kaori Shinjo, MD, and Rynzo Ohno, MDAkihiro Takeshita, MDHamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Takeshita)Hamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Shinjo)Hamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Ohno)Search for more papers by this author, Kaori Shinjo, MDHamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Takeshita)Hamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Shinjo)Hamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Ohno)Search for more papers by this author, and Rynzo Ohno, MDHamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Takeshita)Hamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Shinjo)Hamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Ohno)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-2-199907200-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 34-year-old Japanese man with chronic myelogenous leukemia (CML) underwent bone marrow transplantation from his HLA-identical brother. Before transplantation, free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) levels were normal. Anti-TSH receptor antibody, thyroid-stimulating antibody, antinuclear antibody, anti-DNA antibody, antithyroglobulin antibody, and antithyroid peroxidase antibody were not detectable. Although the patient did not have acute graft-versus-host disease, 11 months after transplantation he developed a chronic form of this disease that spontaneously resolved without therapy in 3 months. The patient also developed clinical symptoms of hyperthyroidism 24 months after transplantation. The TSH level was less than ...References1. Paschke R, Vogg M, Swillens S, Usadel KH. Correlation of microsomal antibodies with the intensity of the intrathyroidal autoimmune process in Graves' disease. J Clin Endocrinol Metab. 1993;77:939-43. MedlineGoogle Scholar2. Inoue D, Sato K, Sugawara H, Akamizu T, Maeda M, Inoko H, et al . Apparent genetic difference between hypothyroid patients with blocking-type thyrotropin receptor antibody and those without, as shown by restriction fragment length polymorphism analyses of HLA-DP loci. J Clin Endocrinol Metab. 1993;77:606-10. MedlineGoogle Scholar3. Aldouri MA, Ruggier R, Epstein O, Prentice HG. Adoptive transfer of hyperthyroidism and autoimmune thyroiditis following allogeneic bone marrow transplantation for chronic myeloid leukemia. Br J Haematol. 1990;74:118-9. CrossrefMedlineGoogle Scholar4. Ichihashi T, Yoshida H, Kiyoi H, Fukutani H, Yamauchi T, Naoe T, et al . Development of hyperthyroidism in donor and recipient after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1992;10:397-8. MedlineGoogle Scholar5. Thomson JA, Wilson RM, Franklin M. Transmission of thyrotoxicosis of autoimmune type by sibling allogeneic bone marrow transplant. Eur J Endocrinol. 1995;133:564-6. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Hamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Takeshita)Hamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Shinjo)Hamamatsu University School of Medicine; Hamamatsu-shi 431-3192, Japan (Ohno) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by2019 European Thyroid Association Guidelines on the Management of Thyroid Dysfunction following Immune Reconstitution TherapyGraves' disease following immune reconstitution or immunomodulatory treatment: should we manage it any differently?Immune reconstitution syndrome and the thyroidAutoimmune thyroid dysfunction after hematopoietic stem cell transplantationLes manifestations d’allure auto-immune après allogreffe de moelle osseuseAppearance of Thyroid Stimulating and Blocking Immunoglobulins after Bone Marrow Transplantation: Presentation of Two Contrasting CasesRelapse of Graves' disease after successful allogeneic bone marrow transplantationAssociation of the HLA A2-B46-DR9 haplotype with autoimmune thyroid dysfunction after bone marrow transplantation in Chinese patients 20 July 1999Volume 131, Issue 2Page: 157KeywordsAutoantibodiesBone marrow transplantationHyperthyroidismLymphocytesPeroxidasesThyroidThyroid-stimulating hormoneThyroxineTransplantationTriiodothyronine Issue Published: 20 July 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...