tbuckley/cabot-search huggingface dataset:
Endometrial Cancer, Epidemiology, and Medical Practice
Authors: Kenneth J. Ryan
Journal: JAMA (1982)

The article by Hulka et al (p 475) in this issue ofThe JOURNALsuggests a halving of the relative risk of endometrial cancer in women, on reaching an average age of 50 years, who were taking a combination birth control pill at the time of the study. This is consonant with other reports that suggest a beneficial effect of progestins in moderating cancer risk from exogenous or endogenous estrogens. It is important to point out what the health care implications of such an observation might be for women in this age group.  The data from this case-control study indicate what the relative benefit might be in reduction of endometrial cancer, but do not reveal the number of subjects at risk for such malignancy or the risk of oral contraceptive (OC) use that can be derived from a different type of epidemiological survey. The incidence of endometrial cancer in women
Progressive 3q Amplification Consistently Targets <i>SOX2</i> in Preinvasive Squamous Lung Cancer
Authors: Frank McCaughan, Jessica C. M. Pole, Alan T. Bankier, Bernard A. Konfortov, Bernadette Carroll, Mary Falzon, Terence H. Rabbitts, P. Jeremy George, Paul H. Dear, Pamela H. Rabbitts
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Rationale: Amplification of distal 3q is the most common genomic aberration in squamous lung cancer (SQC). SQC develops in a multistage progression from normal bronchial epithelium through dysplasia to invasive disease. Identifying the key driver events in the early pathogenesis of SQC will facilitate the search for predictive molecular biomarkers and the identification of novel molecular targets for chemoprevention and therapeutic strategies. For technical reasons, previous attempts to analyze 3q amplification in preinvasive lesions have focused on small numbers of predetermined candidate loci rather than an unbiased survey of copy-number variation.Objectives: To perform a detailed analysis of the 3q amplicon in bronchial dysplasia of different histological grades.Methods: We use molecular copy-number counting (MCC) to analyze the structure of chromosome 3 in 19 preinvasive bronchial biopsy specimens from 15 patients and sequential biopsy specimens from 3 individuals.Measurements and Main Results: We demonstrate that no low-grade lesions, but all high-grade lesions, have 3q amplification. None of seven low-grade lesions progressed clinically, whereas 8 of 10 patients with high-grade disease progressed to cancer. We identify a minimum commonly amplified region on chromosome 3 consisting of 17 genes, including 2 known oncogenes, SOX2 and PIK3CA. We confirm that both genes are amplified in all high-grade dysplastic lesions tested. We further demonstrate, in three individuals, that the clinical progression of high-grade preinvasive disease is associated with incremental amplification of SOX2, suggesting this promotes malignant progression.Conclusions: These findings demonstrate progressive 3q amplification in the evolution of preinvasive SQC and implicate SOX2 as a key target of this dynamic process.
Endoscopic hemostasis using covered metallic stent placement for uncontrolled post-endoscopic sphincterotomy bleeding
Authors: T. Itoi, I. Yasuda, S. Doi, T. Mukai, T. Kurihara, A. Sofuni
Journal: Endoscopy (2011)

Severe bleeding following endoscopic biliary sphincterotomy (EBS) can sometimes be difficult to manage, resulting in the need for an invasive intervention. The aim of this study was to retrospectively evaluate the feasibility and efficacy of endoscopic hemostasis using covered self-expandable metallic stents (SEMSs) for severe post- EBS bleeding. Eleven patients with bile duct stones underwent standard EBS using a standard sphincterotome-based technique at 4 endoscopic units of a university-affiliated hospital and a general hospital. Monotherapy or combined therapy were used to achieve hemostasis with either balloon tamponade, hypertonic saline epinephrine injection, or endoclip placement. When active bleeding could not be controlled, covered SEMSs were placed across the major papilla. Emergency endoscopy was performed on the day of admission or the subsequent day (ranging from 6 to 35 h after admission). Bleeding was classified as mild in 6 cases (54.5 %) and moderate in 5 (45.5 %). A covered SEMS 10mm in diameter and 6 cm long was placed across the papilla. After placement, complete hemostasis was achieved. The mean duration of stent placement was 8.2 days (range 5–10 days), and the SEMS was successfully removed in all cases. Although the present study has the limitations of a small sample size and lack of control patients, covered SEMS placement for endoscopic hemostasis may be useful in selected patients with uncontrolled post-EBS bleeding.
Hospitalist Workload
Authors: Robert M. Wachter
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Near-Syncope After Exercise
Authors: Roy C. Ziegelstein
Journal: JAMA (2004)

Syncope and near-syncope are great diagnostic challenges in medicine. On the one hand, the symptom may result from a benign condition and pose little or no threat to health other than that related to falling. On the other hand, syncope or near-syncope can be the manifestation of a serious underlying condition that poses an imminent threat to life. Patients with a cardiac cause of syncope are at far greater risk of dying in the first year after an episode of syncope or near-syncope than individuals with a noncardiac cause. A cardiac cause of syncope should be considered in every patient with syncope or near-syncope, but it is particularly common in older patients or in patients with known structural heart disease, arrhythmia, or certain electrocardiographic abnormalities. Although many diagnostic tests may be helpful in the evaluation of syncope and near-syncope, the history, physical examination, and electrocardiogram pinpoint the cause in many circumstances. Syncope after exercise may be due to left ventricular outflow tract obstruction from aortic stenosis or hypertrophic obstructive cardiomyopathy but can also suggest the diagnosis of postexercise hypotension in which an abnormality in autonomic regulation of vascular tone or heart rate results in vasodilation or bradycardia after moderate-intensity aerobic activity. The patient discussed in this case highlights the importance of the clinical history in the evaluation of this condition, since the diagnosis was revealed as the patient's story was described and eventually acted out.
Do cases like that of Anders Breivik show that fanaticism is a form of madness? Yes
Authors: M. Taylor
Journal: BMJ (2012)

The trial of Anders Breivik, who murdered 77 people in two attacks in Norway, has attracted considerable controversy because of the questions concerning his mental state. <b>Max Taylor</b> argues that such extreme fanatics should be considered insane, but <b>Tom Fahy</b> (doi:10.1136/bmj.e4647) believes that a psychiatric diagnosis is an abrogation of personal and societal responsibility
New mothers are most likely to be depressed four years after giving birth
Authors: I. Torjesen
Journal: BMJ (2014)

Mothers are more likely to be depressed four years after childbirth than at any point in the first 12 months after giving birth, a study in BJOG: An International Journal of Obstetrics and Gynaecology has found.1 Women with only one child at four years post partum were more than twice as likely to report depressive symptoms as women with more children, the results of the Australian study showed.

The researchers recruited 1507 women to the study who were registered to give birth to their first child at six public hospitals in Melbourne. The women then completed questionnaires at 3, 6, 12, and 18 months, and then at four …
Comparative efficacy of rice-based and glucose-based oral rehydration salts plus early reintroduction of food
Authors: I.M. Fayad, M. Hashem, M. Refat, M. Bakir, O. Fontaine, C. Duggan, M. Santosham
Journal: The Lancet (1993)

The use of oral rehydration salts (ORS) to restore fluid balance in children with diarrhoea is universally accepted. However, there is uncertainty about whether glucose-based ORS or ORS based on precooked rice powder is more effective. In a randomised trial we compared the two types of ORS in children who were given food immediately after completion of rehydration. 460 boys aged 3-18 months, admitted to hospital with acute diarrhoea and signs of dehydration, were randomly assigned to groups receiving rice-based and glucose-based ORS solution (230 to each group). After full rehydration (4-12 h), a weaning food consisting of rice and mixed vegetables was given until the diarrhoea stopped. Continuing losses of liquid stool and vomitus were replaced with the assigned ORS solution. There were no differences between the groups during the rehydration phase in stool volume, volume of ORS solution taken, duration of rehydration phase, or weight gain. However, after initiation of feeding, the glucose-based ORS group had significantly lower stool volumes than the rice-based ORS group (142 [95% CI 117-173] vs 96 [77-120] g/kg); they also took a smaller amount of ORS solution (153 [127-185] vs 111 [90-136] mL/kg) and had a shorter duration of diarrhoea (55 [SD 35] vs 44 [35] h). Glucose-based ORS solution was more effective than rice-based ORS solution for the treatment of diarrhoea in children when feeding with a rice-based diet was started soon after correction of dehydration. These results support the continued recommendation of glucose-based ORS solution as standard therapy for treatment of children with acute diarrhoea and emphasize the importance of resuming feeding as soon as dehydration has been corrected.
Correlation of mean pulmonary artery wedge pressure, left atrial dimention, and PTF-V1 in patients with acute myocardial infarction.
Authors: J Orlando, M Del Vicario, W S Aronow, J Cassidy
Journal: Circulation (1977)

The mean pulmonary artery wedge pressure (PAWP), left atrial dimension (LAD) by echocardiography, and PTF-V1 in the electrocardiogram were correlated with each other in 16 patients with acute myocardial infarction in the control period and after therapeutic intervention with either Dextran or furosemide and/or nitroprusside. No significant correlation was found between a normal control PAWP and the LAD. An increased control PAWP correlated well with an increased LAD (r = 0.98). No significant correlation was found between the LAD and the PAWP whether normal or elevated after therapeutic intervention. No significant correlation was found between the PAWP whether normal or elevated and the PTF-V1. No significant correlation was found between the LAD and the PTF-V1. We conclude in acute myocardial infarction 1) the PTF-V1 is not useful in assessing PAWP before or after therapeutic intervention, 2) the LAD correlates poorly with a normal control PAWP but correlates well with an elevated control PAWP, and 3) the LAD cannot be used to assess PAWP after therapeutic intervention.
A NEW BLOOD TRANSFUSION METHOD
Authors: Philip H. Kreuscher
Journal: JAMA (1918)

The transfusion of blood has been rightfully considered a major procedure. This circumstance is due to the facts that first, the operation, until very recently, was done only in the greatest emergency; second, the technical details could be mastered only after repeated trials; third, when not done properly and carefully in every detail, the operation often proved fatal. From time to time, the methods have been simplified until, at present, the physician is told that he may collect a quantity of blood from the donor, and after adding a small quantity of sodium citrate solution, he may carry it from his office to the hospital and inject the modified blood into the vein of the recipient. This method, which is said to have given good results in the hands of some men, is open to serious objection. It would seem to me that the most rational procedure would be the
MORTALITY FROM GOUT
Authors: Walter G. Bowerman
Journal: JAMA (1942)

To the Editor:—  During the last ten years there were 2,400 deaths attributed to gout in England and Wales, of which five sixths were of men. During the same period, 1930-1939, there were 25 deaths allocated to this cause in the United States, of which two thirds were of men. Allowing for the difference in population, this would be about 10 as compared with 2,400 in England and Wales. Thus the deaths in this country are only about one two-hundredth of the corresponding deaths in England.  I doubt whether such a remarkable contrast could be found for any other cause of death. This is the more noteworthy because such a large part of our population are of British descent and in many respects the two groups are of a similar nature.  It has been suggested that in Great Britain they have attributed a number of deaths to gout which in
Abstract 2454: In vivo binding of chTNT-1/B antibodies (Cotara) to DNA/histone complexes in tumors using near-infrared optical imaging
Authors: Jian Gong, Roy Sevilla, Vince Nguyen, Seth Fisher, Jessica Alldredge, Jessie Kinjo, Rich Archer, Matthew Peacock, Christopher Hughes, Connie Chang, Bruce Freimark
Journal: Cancer Research (2012)

Abstract Tumors contain both microscopic and macroscopic areas of necrotic cells. These have abnormal cell membrane permeability, which allows passage of large macromolecules such as antibodies into the cell. 131I-chTNT-1/B antibody (Cotara) is a novel, single administration agent designed to target tumor necrosis that has completed a Phase II clinical trial for recurrent glioblastoma multiforme (GBM), showing 9.3 month median overall survival for patients. Since 131I-chTNT-1/B antibody is a high-molecular-mass protein, it cannot easily pass from the systemic circulation through the blood-brain barrier (BBB) and thus can only be delivered locally by an intratumoral catheter. We have developed a human ME-180 cervical carcinoma xenograft tumor model in nude mice to characterize the targeting of chTNT-1/B to necrotic areas using near infrared (NIR) optical imaging. The use of NIR optical imaging is a powerful translational tool to monitor in vivo antibody targeting. chTNT-1/B was labeled with a NIR fluorescent dye and kinetics of antibody retention in tumors was measured by NIR optical imaging following intratumoral injection of the NIR-chTNT-1/B. NIR-chTNT-1/B was retained in ME180 tumors for a longer duration compared to NIR dye alone. Labeling of chTNT-1/B with a low dye/protein ratio was necessary to demonstrate maximum specific targeting to tumor necrosis. Evaluation of in vivo antibody targeting to tumors using NIR imaging may facilitate improvements for treatment of patients with malignant glioma with Cotara. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2454. doi:1538-7445.AM2012-2454
Cutaneous manifestations of Paecilomyces lilacinus infection induced by a contaminated skin lotion in patients who are severely immunosuppressed
Authors: P.H. Itina, R. Freib, S. Lautenschlagera, S.A. Buechnera, C. Surberc, A. Gratwohld, A.F. Widmere
Journal: Journal of the American Academy of Dermatology (1998)
Cbfβ-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia
Authors: Ya-Huei Kuo, Sean F. Landrette, Susan A. Heilman, Paola N. Perrat, Lisa Garrett, Pu P. Liu, Michelle M. Le Beau, Scott C. Kogan, Lucio H. Castilla
Journal: Cancer Cell (2006)
Extent of bile acid-induced hepatic damage dictates activin a secretion in HepG2 cells
Authors: M. Concari, P. Loria, A.M. Verrone, F. Petraglia, S. Luisi, M. Bertolotti, P. Martella, M.A. Croce, R. Tiozzo, F. Carubbi, N. Carulli
Journal: Journal of Hepatology (2000)
Concomitant Pancreatic Activation of KrasG12D and Tgfa Results in Cystic Papillary Neoplasms Reminiscent of Human IPMN
Authors: Jens T. Siveke, Henrik Einwächter, Bence Sipos, Clara Lubeseder-Martellato, Günter Klöppel, Roland M. Schmid
Journal: Cancer Cell (2007)
Kaposi's Sarcoma Without Human Immunodeficiency Virus Antibody in a Hemophiliac
Authors: P. M. MANNUCCI
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 September 1986Kaposi's Sarcoma Without Human Immunodeficiency Virus Antibody in a HemophiliacP. M. MANNUCCI, M.D., P. QUATTRONE, M.D., L. MATTURRI, M.D.P. M. MANNUCCI, M.D.Search for more papers by this author, P. QUATTRONE, M.D.Search for more papers by this author, L. MATTURRI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-3-466_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Kaposi's sarcoma is a rare manifestation of the acquired immunodeficiency syndrome (AIDS) in hemophiliacs (1). We describe a case with a rapidly progressive clinical course and other unusual aspects.A 30-year-old heterosexual man with severe hemophilia A had a high-potency alloantibody to factor VIII. Between referral to us (1975) and June 1985, he was treated with an average of 9000 IU/year of factor VIII concentrates (manufactured in the United States) and 9500 IU/year of factor IX concentrates (only heated concentrates were used since 1984). At visits in 1983 and 1984, the patient, who denied using illicit drugs...References1. . Update: acquired immunodeficiency syndrome (AIDS) in persons with hemophilia. MMWR. 1984;33:589-92. MedlineGoogle Scholar2. SAFAIJOHNSONMYSKOWSKI BKP. The natural history of Kaposi's sarcoma in the acquired immunodeficiency syndrome. Ann Intern Med. 1985;103:744-50. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Institute of Morbid Anatomy 20122 Milano Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCD4 similarity to proteins of infectious agents in AIDS and their role in autoimmunityKaposi's sarcoma: its ‘oncogenes’ and growth factorsIncreased incidence of Kaposi sarcoma in Sweden before the AIDS epidemicHistometric studies on cellular infiltrates of tuberculin tests in patients with haemophilia.Tödlich verlaufene AIDS-Fälle bei einem Hämophilen (mit Kaposi-Sarkom) und seiner LebenspartnerinFulminant Kaposi's sarcoma complicating long-term corticosteroid therapy 1 September 1986Volume 105, Issue 3Page: 466-466KeywordsAIDSDrugsHIVHemophilia AHeterosexualsKaposi sarcoma Issue Published: 1 September 1986 PDF DownloadLoading ...
Proteomics Analysis of Cardiac Extracellular Matrix Remodeling in a Porcine Model of Ischemia/Reperfusion Injury
Authors: Javier Barallobre-Barreiro, Athanasios Didangelos, Friedrich A. Schoendube, Ignat Drozdov, Xiaoke Yin, Mariana Fernández-Caggiano, Peter Willeit, Valentina O. Puntmann, Guillermo Aldama-López, Ajay M. Shah, Nieves Doménech, Manuel Mayr
Journal: Circulation (2012)

Background— After myocardial ischemia, extracellular matrix (ECM) deposition occurs at the site of the focal injury and at the border region. Methods and Results— We have applied a novel proteomic method for the analysis of ECM in cardiovascular tissues to a porcine model of ischemia/reperfusion injury. ECM proteins were sequentially extracted and identified by liquid chromatography tandem mass spectrometry. For the first time, ECM proteins such as cartilage intermediate layer protein 1, matrilin-4, extracellular adipocyte enhancer binding protein 1, collagen α-1(XIV), and several members of the small leucine-rich proteoglycan family, including asporin and prolargin, were shown to contribute to cardiac remodeling. A comparison in 2 distinct cardiac regions (the focal injury in the left ventricle and the border region close to the occluded coronary artery) revealed a discordant regulation of protein and mRNA levels; although gene expression for selected ECM proteins was similar in both regions, the corresponding protein levels were much higher in the focal lesion. Further analysis based on &gt;100 ECM proteins delineated a signature of early- and late-stage cardiac remodeling with transforming growth factor-β1 signaling at the center of the interaction network. Finally, novel cardiac ECM proteins identified by proteomics were validated in human left ventricular tissue acquired from ischemic cardiomyopathy patients at cardiac transplantation. Conclusion— Our findings reveal a biosignature of early- and late-stage ECM remodeling after myocardial ischemia/reperfusion injury, which may have clinical utility as a prognostic marker and modifiable target for drug discovery.