tbuckley/cabot-search huggingface dataset:
Power Spectral Analysis of Heart Rate Variability in Psychiatry
Authors: Hagit Cohen, Michael A. Matar, Zeev Kaplan, Moshe Kotler
Journal: Psychotherapy and Psychosomatics (1999)

Power spectrum analysis of heart rate variability (PSA of HRV) is a promising method, which can be used as an index of cardiac autonomic balance. PSA of HRV is a noninvasive technique, based on ECG sampling of RR interval variation, thus providing a dynamic assessment of sympathetic and parasympathetic tone, reflecting the interactions between the two. It has been shown to have potential value in various laboratory and clinical conditions. It is influenced by many factors such as age, sex, position, breathing, smoking, hour of the day and medications. Different methods of data processing by various authors have often elicited conflicting results. Standard values are not yet available to be used or compared in different settings. From the interest it has raised, it may be expected that this method will be in widespread use in clinical practice in the future, providing a useful tool, both for diagnostic and prognostic purposes, as well as serving as a further aid towards monitoring therapeutic interventions. This review highlights techniques of dynamic assessment of HRV and studies of its clinical applications in psychiatry in particular. It raises the potentially important prognostic implications of protracted autonomic dysfunction in psychiatric patient populations, especially for cardiovascular morbidity and mortality.
THE CARDIAC INDICATIONS AND CONTRAINDICATIONS IN THE TREATMENT OF PNEUMONIA.
Authors: J. M. ANDERS
Journal: JAMA (1892)

It is a well known fact that in acute lobar pneumonia failure of heart power is the immediate cause of death, as a rule. In the first place there are three leading factors which enter into the causation of cardiac-insufficiency in this disease, which factors may operate singly or in combination. They may be conveniently considered under as many different heads, to-wit: First. The heart failure may be due to the toxic effects of the ptomaines present in the blood, on the heart muscle and ganglia. Secondly. It may be due in part at least to the obstruction offered to the pulmonary circulation by the inflammatory exudate in the air vessicles. Thirdly. The formation of cardiac thrombi may lead to right ventricular dilatation and exhaustion of heart power. Pneumonia belongs to the acute infectious diseases, hence it is intelligible that on account of the overwhelming of the system by the
When do epileptic patients need treatment? Starting and stopping medication.
Authors: D Chadwick, E H Reynolds
Journal: BMJ (1985)

Decisions about when to start and stop antiepileptic treatment have important implications for patients with epilepsy. Clinical practice varies and is determined more by dogmatic teaching than by knowledge of either the clinical course of epilepsy or the influence of the drugs. A review of the available evidence shows the need for further studies on the effects of starting and withdrawing treatment on the clinical course and prognosis of epilepsy.
A Crisis in Medical Education
Authors: James V. Warren
Journal: JAMA (1985)

ON MARCH 1 and 2, 1984, the faculty of The Ohio State University College of Medicine, Columbus, celebrated its sesquicentennial by holding a conference, with nine distinguished speakers, entitled Medical Education for the 21st Century.<sup>1</sup>It occurred to us, the major architects of this symposium, that it might be useful to record a consolidated and somewhat impressionistic view of what we learned. This article represents our reflections, as stimulated by both formal talks and informal discussions, during this excellent conference. <h3>THE WORLD OF MEDICINE AS IT MOVES THROUGH TIME</h3> Much discussion at the conference focused on the global concept of the "world of medicine": the world in which medical education takes place. No totally satisfactory term can be found for this large and complex "world of medicine." It includes such components as biomedical science; medical practice; the entire health care delivery system; medical economics; health professions education; the public's perceptions
Challenges to HIV Prevention — Seeking Effective Measures in the Absence of a Vaccine
Authors: Stephen W Lagakos, Alicia R Gable
Journal: New England Journal of Medicine (2008)

In the 15 to 20 years it may take to develop and evaluate a highly efficacious vaccine, the world may be facing 20 to 60 million new HIV infections. Stephen Lagakos and Alicia Gable write that it is critical to learn how to optimize the use of multiple, partially effective biomedical and behavioral interventions in the settings and populations in which they are most effective.
Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation
Authors: Wenshi Gao, Rex C. Bentley, John F. Madden, Pierre-Alain Clavien
Journal: Hepatology (1998)

In livers excised for transplantation, sinusoidal endothelium appears especially vulnerable to injury during organ preservation in the cold and subsequent reperfusion. The degree of endothelial cell injury correlates with functional impairment of the graft following transplantation. The mechanism of injury remains obscure, but endothelial cell damage has been described as coagulative necrosis secondary to irreversible physico-chemical damage. We investigated whether endothelial cell death is caused by apoptosis rather than by necrosis. Tissue from rat livers stored for varying periods in cold (1°C) Euro-Collins solution and then reperfused for 1 hour at 37°C were studied for evidence of apoptosis by detection of DNA fragmentation using the in situ terminal deoxynucleotidyl transferase d-uridine triphosphate nick end labeling (TUNEL) assay, DNA gel electrophoresis, and by transmission electron microscopy (EM). DNA fragmentation of the type characteristic of apoptosis was identified in 49.7% ± 2.2% of sinusoidal lining cells after 8 hours of ischemia + reperfusion (viable graft) vs. 70.7% ± 4.3% after 16 hours + reperfusion (nonviable graft) ( P &lt; .001). No such fragmentation was observed after cold preservation without reperfusion or in unpreserved, reperfused livers. EM demonstrated changes characteristic of apoptosis exclusively in endothelial cells. The study suggests that the apoptosis of sinusoidal endothelial cells is a pivotal mechanism of preservation injury in liver transplantation.
Breast-Feeding and Risk for Childhood Obesity
Authors: Andreas Plagemann, Thomas Harder, Elke Rodekamp, Joachim W. Dudenhausen
Journal: Diabetes Care (2007)

We read with great interest the recent study by Mayer-Davis et al. (1) on the impact of breast-feeding on childhood obesity risk in the presence of maternal diabetes or obesity. The authors drew conclusions that seem to directly oppose previous observations from our group (2,3). However, we would like to deliver three arguments suggesting that the presented data can also be interpreted in a completely different manner and in no way exclude, but rather support, a …
Human consumption of methyleugenol and its elimination from serum.
Authors: Arnold Schecter, George W Lucier, Michael L Cunningham, Kamal M Abdo, Greg Blumenthal, Andrew G Silver, Ron Melnick, Christopher Portier, Dana B Barr, John R Barr, Stephen B Stanfill, Donald G Patterson, Larry L Needham, Woodhall Stopford, Scott Masten, Jill Mignogna, Kuang Chi Tung
Journal: Environmental Health Perspectives (2004)

Under a mandate from the U.S. Congress, the National Toxicology Program (NTP) of the U.S. Department of Health and Human Services conducts animal bioassays for carcinogenicity of potentially toxic chemicals to which the U.S. population might be exposed. Methyleugenol, a natural as well as synthesized substance, was nominated for study because it is structurally similar to safrole, a known animal carcinogen. Methyleugenol was found to be a very potent multisite carcinogen in male and female F344/N rats and B6C3F1 mice at all doses tested in 2-year NTP bioassays using gavage dosing. For this reason, human toxicokinetic studies were added to the traditional NTP protocol. A commercial brand of gingersnaps was found by chemists at the Centers for Disease Control and Prevention to contain a relatively high concentration of methyleugenol. After thorough scientific and clinical review, and approval by a National Institutes of Health institutional review board for the protection of human subjects, a study was conducted with nine healthy adult male and female human volunteers. The volunteers were given 12 gingersnaps for breakfast. Blood was drawn immediately before the meal and at 15, 30, 60, and 120 min afterward. The mean +/- SD fasting level of methyleugenol in serum was 16.2 +/- 4.0 pg/g wet weight. Peak blood levels were found at 15 min (mean +/- SD, 53.9 +/- 7.3 pg/g wet weight), followed by a rapid decline; the half-life of elimination was about 90 min. The peak levels were within the range of methyleugenol blood levels in the U.S. population, as measured concurrently in a subset of nonfasting participants in the Third National Health and Nutrition Examination Survey (NHANES III).
Treatment of breast infection
Authors: J. M. Dixon, L. R. Khan
Journal: BMJ (2011)

#### Summary points

A cohort study of American women reported that 10% of women who breast feed have mastitis,1 and a recent Cochrane review reported the incidence to be as high as 33%.2 Breast abscesses are seen less often, but when they do develop delays in referral to a specialist surgeon may occur. A recent survey in the United Kingdom found that many surgical units have no clear protocols for managing patients with breast infection who are referred to hospital.3 Some surgeons aspirate breast abscesses under local anaesthesia, whereas others use general anaesthesia. The management of breast infection has evolved over the past two decades, with advances in both diagnosis and treatment. A new concept is bedside ultrasound, and this plays an important part in current management. 

We review management of breast infection in the primary care setting and after hospital referral. The review is based on our current practice and the best quality evidence available. Few randomised controlled trials deal with this topic, and most breast specialists have adopted their own protocols for clinical management, loosely based on published algorithms, and largely …
Effects of the calcineurin dependent signaling pathway inhibition by cyclosporin A on early and late cardiac remodeling following myocardial infarction
Authors: Tae‐jin Youn, Hainan Piao, Jin‐sook Kwon, So‐young Choi, Hyung‐sam Kim, Dae‐gyun Park, Dong‐woon Kim, Young‐gyu Kim, Myeong‐chan Cho
Journal: European Journal of Heart Failure (2002)
Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression.
Authors: S Mohapatra, X Yang, J A Wright, E A Turley, A H Greenberg
Journal: The Journal of Experimental Medicine (1996)

The hyaluronan (HA) receptor RHAMM is an important regulator of cell growth. Overexpression of RHAMM is transforming and is required for H-ras transformation. The molecular mechanism underlying growth control by RHAMM and other extracellular matrix receptors remains largely unknown. We report that soluble RHAMM induces G2/M arrest by suppressing the expression of Cdc2/Cyclin B1, a protein kinase complex essential for mitosis. Down-regulation of RHAMM by use of dominant negative mutants or antisense of mRNA also decreases Cdc2 protein levels. Suppression of Cdc2 occurs as a result of an increased rate of cdc2 mRNA degradation. Moreover, tumor cells treated with soluble RHAMM are unable to form lung metastases. Thus, we show that mitosis is directly linked to RHAMM through control of Cdc2 and Cyclin B1 expression. Failure to sustain levels of Cdc2 and Cyclin B1 proteins leads to cell cycle arrest.
A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients
Authors: Mariusz Z. Ratajczak, Chi Hwa Kim, Ahmed Abdel-Latif, Gabriela Schneider, Magda Kucia, Andrew J. Morris, Mary J. Laughlin, Janina Ratajczak
Journal: Leukemia (2011)
The Clinical Relevance of Steroid Hormone Receptor Corepressors
Authors: Rakesh Kumar, Anupama E. Gururaj, Ratna K. Vadlamudi, Suresh K. Rayala
Journal: Clinical Cancer Research (2005)

Steroid hormone receptors are ligand-dependent transcription factors that control a variety of essential physiologic and developmental processes in humans. The functional activity of a steroid receptor is regulated not only by hormones but also by an array of regulatory proteins such as coactivators, corepressors, and chromatin modifiers. Contrary to an earlier notion that corepressors and coactivators exist in separate complexes, these molecules, which have apparently opposite functions, are increasingly being found in the same complex, which allows for efficient transcriptional control mechanisms. These control mechanisms are in turn regulated by an array of post-translational modifications under the influence of upstream and local signaling networks. Because the outcome of steroidal hormone receptor transcriptional complexes is measured in terms of the expression of target genes, any dysregulation of coregulator complexes perturbs normal homeostasis and could contribute to the development and maintenance of malignant phenotypes. Increasing evidence implicating steroid hormone receptors and their coregulators in various pathophysiologic conditions has elicited interest in their structure and biology. Further advances in this field of study should open up a unique window for novel targeted therapies for diseases such as cancer. Here we briefly review the clinical relevance of corepressors, with a particular focus on their role in the development of cancerous phenotypes.
Textbook of Rheumatology
Authors: John H. Talbott
Journal: JAMA (1981)

Students of internal medicine have enjoyed the publication of a truly great textbook in their field in each quarter of the current century. William Osier, in 1892, published a revolutionary new text,<i>The Principles and Practice of Medicine</i>. This was based on the imaginative planning of a new curriculum for students and house staff, a template for medical education at the recently planned Johns Hopkins Hospital and Medical School in Baltimore. It was founded on advances in medical science, especially bacteriology, during the preceding decades. Osler listed no contributors or co-editors in his book. It was a solo but important academic effort; it remained the standard for decades and enjoyed innumerable editions, even a resurrection as recently as 1972. More than a quarter of a century after the initial edition of Osler, Russell L. Cecil of New York published his<i>Textbook of Medicine</i>in 1927 with the help of more
LYMPHOBLAST TRANSFOEMATION IN SULPHONAMIDE SENSITIVITY.
Authors: G. A. CARON, I. SARKANY
Journal: British Journal of Dermatology (1965)

Journal Article LYMPHOBLAST TRANSFOEMATION IN SULPHONAMIDE SENSITIVITY. Get access G. A. CARON, G. A. CARON Department of Dermatology, Royal Free Hospital, London, W.C.I Search for other works by this author on: Oxford Academic Google Scholar I. SARKANY I. SARKANY Department of Dermatology, Royal Free Hospital, London, W.C.I Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 11, 1 November 1965, Pages 556–559, https://doi.org/10.1111/j.1365-2133.1965.tb14575.x Published: 01 November 1965
Bovine angiotensin converting enzyme cDNA cloning and regulation. Increased expression during endothelial cell growth arrest.
Authors: S Y Shai, R S Fishel, B M Martin, B C Berk, K E Bernstein
Journal: Circulation Research (1992)

Angiotensin converting enzyme (ACE) is a zinc-containing dipeptidase that converts angiotensin I to angiotensin II, a powerful vasoconstrictor and smooth muscle growth factor. ACE activity has been shown to be dynamically regulated by hormones, ACE inhibitors, and endothelial cell growth state. To study how ACE expression is regulated, we isolated and sequenced the bovine ACE gene using both ACE-specific cDNA and genomic clones. Bovine ACE cDNA encodes a single polypeptide of 1,306 residues with a molecular mass of 150 kd. Bovine ACE is approximately 80% homologous to that of other species. It contains two homologous domains of equal size. Alignment of ACE sequences from bovine, human, mouse, and rabbit reveals that during evolution both domains have been highly conserved. We used the bovine ACE cDNA to study regulation of ACE gene expression during density-dependent growth arrest. As endothelial cells became growth-arrested (6 days after confluence), there was a 12-fold increase in ACE activity and a 90% decrease in DNA synthesis. Immunocytochemically detectable ACE markedly increased in growth-arrested cells. The increase in ACE was due to increased ACE gene expression, as assayed by RNase protection, which showed a 20-fold increase in ACE-specific mRNA. The present study shows that bovine ACE is highly regulated by endothelial cell growth state at the level of protein and mRNA expression. Such dynamic regulation may have important consequences for angiotensin II production during endothelial cell proliferation after arterial injury.
RELATIONSHIP BETWEEN BLOOD FLOW VELOCITY AND RADIOFREQUENCY SIGNAL ANALYSIS OF BLOOD SPECKLES: AN EXPERIMENTAL STUDY USING INTEGRATED BACKSCATTER IVUS
Authors: Hideki Kitahara, Shigemitsu Tanaka, Kyuhachi Otagiri, Yuhei Kobayashi, Kozo Okada, Kaori Nakagawa, Fumiaki Ikeno, Paul Yock, Peter Fitzgerald, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2014)
Prognostic impact of p27KIP1 expression in cyclin D1 positive lymphoproliferative disorders
Authors: R Letestu, V Ugo, F Valensi, I Radford-Weiss, J Nataf, V Lévy, J G Gribben, X Troussard, F Ajchenbaum-Cymbalista
Journal: Leukemia (2004)
SUNLIGHT AND DARIEE'S DISEASE
Authors: T. HEYL
Journal: British Journal of Dermatology (1971)

Journal Article SUNLIGHT AND DARIEE'S DISEASE Get access T. HEYL T. HEYL Section of Dermatology, University of Pretoria, South Africa Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue s7, 1 December 1971, Pages 57–59, https://doi.org/10.1111/j.1365-2133.1971.tb14111.x Published: 01 December 1971
TUMOR OF THE CECUM AND ASCENDING COLON; REMOVAL AND RECOVERY.
Authors: A. B. KNOWLTON
Journal: JAMA (1906)

<h3>History.</h3> —The patient, a lady aged 56, unmarried, was admitted to my infirmary as the patient of Dr. E. J. Wannamaker of Columbia, S. C. She weighed about 96 pounds, being emaciated from twenty years of gradually increasing intestinal obstruction. No bowel movement could be had except in response to patient, persistent and painful effort, both by enemata and by powerful purgatives. In consequence her suffering had gradually increased, each exacerbation becoming more and more pronounced till her condition was that both of physical suffering and mental anguish, which only slowly increasing intestinal obstruction can induce. The patient periodically eructated quantities of gas and vomited nearly all liquids and nourishment. Anodynes gave her her only relief, except occasionally when in response to cathar tics, and by dint of much suffering, a few drams of fecal matter would pass. <h3>Examination.</h3> —The abdomen was enlarged from chronic gaseous distension and fecal retention.
Enhancement of Vincristine Cytotoxicity in Drug-Resistant Cells by Simultaneous Treatment With Onconase, an Antitumor Ribonuclease
Authors: Susanna M. Rybak, John W. Pearson, William E. Fogler, Kirk Volker, Sally E. Spence, Dianne L. Newton, Stanislaw M. Mikulski, Wojciech Ardelt, Charles W. Riggs, Hsiang-Fu Kung, Dan L. Longo
Journal: JNCI Journal of the National Cancer Institute (1996)

Background: Onconase, a protein isolated from oocytes and early embryos of the frog Rana pipiens , shares extensive homology with bovine pancreatic ribonuclease (RNase A) and possesses similar enzyme activity. Onconase is cytotoxic toward cancer cells in vitro and exhibits antitumor activity in animal models. In addition, Onconase has been shown to enhance the cytotoxic activity of some chemotherapeutic agents in vitro.
A Sinister Development
Authors: Reza Fazel, James B. Froehlich, David M. Williams, Sanjay Saint, Brahmajee K. Nallamothu
Journal: New England Journal of Medicine (2007)

A 35-year-old woman presented to the emergency department with a 2-day history of progressive swelling and pain in her left leg, without antecedent trauma. Her pain worsened acutely during the morning before her arrival. She felt warm but reported no fever or chills. She also reported mild dyspnea during the previous day, with no associated chest discomfort or significant immobility.
Access to Medical Care for Black and White Americans
Authors: Robert J. Blendon
Journal: JAMA (1989)

A 1986 national survey of use of health services shows a significant deficit in access to health care among black compared with white Americans. This gap was experienced by all income levels of black Americans. In addition, the study points to significant underuse by blacks of needed medical care. Moreover, blacks compared with whites are less likely to be satisfied with the qualitative ways their physicians treat them when they are ill, more dissatisfied with the care they receive when hospitalized, and more likely to believe that the duration of their hospitalizations is too short. (<i>JAMA</i>1989;261:278-281)
Incidence of malignant melanoma of the skin.
Authors: S Evans
Journal: BMJ (1980)

intermediate social and economic conditions, has a similar prevalence of gall stones at necropsy to that found in several English towns.However, the death rate from ischaemic heart disease in Scotland was 260o greater for males under 60 and 60%, greater for females in the same age group.We do not have sufficient information to analyse statistically the relationship between gall stones and ischaemic heart disease, but these figures suggest that the negative correlation described by Dr Barker does not apply to this region.