tbuckley/cabot-search huggingface dataset:
Differential Recognition of the 52–Kd Ro(Ss–A) Antigen by Sera From Patients With Primary Biliary Cirrhosis and Primary Sjogren's Syndrome
Authors: T Dorner, E Feist, C Held, K Conrad, G R Burmester, F Hiepe
Journal: Hepatology (1996)

Antibodies against the 52–kd Ro(SS–A) protein are significantly associated with the primary Sjogren's syndrome (pSS). A small proportion of patients suffering from primary biliary cirrhosis (PBC) with secondary Sjogren's syndrome (PBC/SS) who are serologically characterized by antimitochondrial type 2 antibodies also express anti–52–kd Ro(SS–A) antibodies. The primary B–cell–derived antigenic responses by autoimmune sera were analyzed in both entities using truncated recombinant proteins to examine whether different epitopes are associated with these diseases. Sera were collected from 25 patients with pSS and 9 anti–52–kd Ro(SS–A)–positive patients suffering from PBC/SS. B–cell epitope mapping was performed using different 52–kd Ro(SS–A) fusion proteins in enzyme–linked immunosorbent assay (ELISA) and immunoblotting. Sera from patients with pSS showed the broadest reactivity against antigenic epitopes at AA 153–245 compared to the significantly limited reactivity against AA 228–245 of sera from patients with PBC. B–cell epitopes within AA 190–245 represent immunodominant epitopes recognized by pSS sera in a significantly higher degree than by PBC sera, which react predominantly with AA 228– 245 ( P &lt; .0001). Anti–La(SS–B) antibodies were significantly associated with anti–52–kd Ro(SS–A) in sera from patients with pSS compared with PBC patients ( P &lt; .025). Thus, the antibody response to 52–kd Ro(SS–A) in PBC appears to be induced differently than in pSS. Although a limited immune response to 52–kd Ro(SS–A) occurs in PBC/SS patients, a more extended epitope spreading is evident in patients with pSS.
Serum Ferritin and Bone Marrow Iron in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis
Authors: Alfred B. Blumberg
Journal: JAMA (1983)

In 20 patients undergoing continuous ambulatory peritoneal dialysis (CAPD), serum ferritin concentration (radioimmunoassay) was compared with bone marrow iron stores (graded semiquantitatively). A close correlation between the two parameters was found. Patients with decreased iron stores (8/20) had serum ferritin concentrations below 70 ng/mL; those with normal or increased iron stores had concentrations above 96 ng/mL. It is concluded that serum ferritin concentrations adequately reflect bone marrow iron stores and are useful as a guide to iron-replacement therapy in patients undergoing CAPD.
Review of the 1984 Year Book of Endocrinology
Authors: THEODORE B. SCHWARTZ
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 March 1985Review of the 1984 Year Book of EndocrinologyTHEODORE B. SCHWARTZ, M.D.THEODORE B. SCHWARTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-3-421_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: This letter is written in response to the thumbnail review of The Year Book of Endocrinology, 1984 (1). While I am quick to concur with the reviewer's judgment that my annotations are composed with "wit and zest," I was stung by the charge that "from a clinician's point of view, the papers selected for abstract and comment run too heavily to papers reporting research on narrow questions and to case reports of highly uncommon disorders."This comment was unsettling enough for me to reexamine the 1984 volume with an apprehensive but still critical eye. I reject the...Reference1. HUTH E. The Year Book of Endocrinology, 1984 [Book review]. Ann Intern Med. 1984;101:891. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center Boise, ID 83702 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1985Volume 102, Issue 3Page: 421-422KeywordsEndocrinologyResearch reporting guidelines Issue Published: 1 March 1985 PDF DownloadLoading ...
Acyclovir and Disseminated Varicella Zoster and Encephalitis
Authors: Daniel V. Ehrensaft, Michael M. Safani
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 March 1985Acyclovir and Disseminated Varicella Zoster and EncephalitisDANIEL V. EHRENSAFT, M.D., MICHAEL M. SAFANI, Pharm.D.DANIEL V. EHRENSAFT, M.D.Search for more papers by this author, MICHAEL M. SAFANI, Pharm.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-3-421_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Intravenous acyclovir has been shown to be effective in the treatment of initial and recurrent herpes simplex virus infections in immunocompetent and immunocompromised persons (1, 2). Although the in-vitro data are impressive, limited information is available on its efficacy in the treatment of varicella zoster encephalitis (3). We report a case of culture-proven disseminated varicella zoster infection and encephalitis successfully treated with high-dose intravenous acyclovir.A 37-year-old white woman with acute lymphoblastic leukemia and leukemic meningitis currently in remission had previously received whole-brain irradiation (total dose, 4400 rad) and then intermittent maintenance chemotherapy with prednisone, vincristine, thioguanine,...References1. MINDELADLERSUTHERLANDFIDDIAN AMSA. Intravenous acyclovir in genital herpes: an interim report. Am J Med. 1982;73(suppl):347-50. CrossrefMedlineGoogle Scholar2. WADENEWTONMCLAREN JBC. Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation: a double-blind trial. Ann Intern Med. 1982;96:265-9. LinkGoogle Scholar3. STEELEKEENEYBRADSHERMOSESSOLOFF RRREB. Treatment of varicella-zoster meningoencephalitis with acyclovir-demonstration of virus in cerebrospinal fluid by electron microscopy. Am J Clin Pathol. 1983;80:57-60. CrossrefMedlineGoogle Scholar4. BRIGDENROSLINGWOODS DAN. Renal function after acyclovir intravenous injection. Am J Med. 1982;73(suppl):182-5. CrossrefMedlineGoogle Scholar5. WADEMYERS JJ. Neurologic symptoms associated with parenteral acyclovir treatment after marrow transplantation. Ann Intern Med. 1983;98:921-5. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memorial Medical Center Long Beach, CA 90801 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHerpes Zoster Associated Encephalitis: Clinical Findings and Acyclovir TreatmentHerpes Zoster Ophthalmicus with Delayed Cerebral Infarction and MeningoencephalitisRapid response to acyclovir in herpes zoster-associated encephalitisCNS Diseases Associated with Varicella Zoster Virus and Herpes Simplex Virus Infection: Pathogenesis and Current Therapy 1 March 1985Volume 102, Issue 3Page: 421-421KeywordsChemotherapyEncephalitisHerpes simplexMeningitisPrecursor cellsThioguanineVaricella zoster virus Issue Published: 1 March 1985 PDF DownloadLoading ...
The Effect of a Plant-Based Diet on Plasma Lipids in Hypercholesterolemic Adults
Authors: Christopher D. Gardner, Ann Coulston, Lorraine Chatterjee, Alison Rigby, Gene Spiller, John W. Farquhar
Journal: Annals of Internal Medicine (2005)

A variety of food combinations can be used to meet national U.S. guidelines for obtaining 30% of energy or less from total fat and 10% of energy or less from saturated fat.To contrast plasma lipid responses to 2 low-fat diet patterns.Randomized clinical trial.4-week outpatient feeding study with weight held constant.120 adults 30 to 65 years of age with prestudy low-density lipoprotein (LDL) cholesterol concentrations of 3.3 to 4.8 mmol/L (130 to 190 mg/dL), body mass index less than 31 kg/m2, estimated dietary saturated fat at least 10% of calories, and otherwise general good health.Plasma lipid levels.Two diets, the Low-Fat diet and the Low-Fat Plus diet, designed to be identical in total fat, saturated fat, protein, carbohydrate, and cholesterol content, consistent with former American Heart Association Step I guidelines. The Low-Fat diet was relatively typical of a low-fat U.S. diet. The Low-Fat Plus diet incorporated considerably more vegetables, legumes, and whole grains, consistent with the 2000 American Heart Association revised guidelines.Four-week changes in the Low-Fat and Low-Fat Plus groups were -0.24 mmol/L (-9.2 mg/dL) versus -0.46 mmol/L (-17.6 mg/dL) for total cholesterol (P = 0.01) and -0.18 mmol/L (-7.0 mg/dL) versus -0.36 mmol/L (-13.8 mg/dL) for LDL cholesterol (P = 0.02); between-group differences were -0.22 mmol/L (-9 mg/dL) (95% CI, -0.05 to -0.39 mmol/L [-2 to -15 mg/dL]) and -0.18 mmol/L (-7 mg/dL) (CI, -0.04 to -0.32 mmol/L [-2 to -12 mg/dL]) for total and LDL cholesterol, respectively. The 2 diet groups did not differ significantly in high-density lipoprotein cholesterol and triglyceride levels.4-week duration.Previous national dietary guidelines primarily emphasized avoiding saturated fat and cholesterol; as a result, the guidelines probably underestimated the potential LDL cholesterol-lowering effect of diet. In this study, emphasis on including nutrient-dense plant-based foods, consistent with recently revised national guidelines, increased the total and LDL cholesterol-lowering effect of a low-fat diet.
Human parvovirus B19 infection and hepatitis
Authors: StanleyJ. Naides, YuoryV. Karetnyi, LauraL.W. Cooling, RodneyS. Mark, AlanN. Langnas, Yuko Yoto, Tooru Kudoh, Keiji Haseyama, Nobuhiro Suzuki, Shunzo Chiba
Journal: The Lancet (1996)
Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan.
Authors: M M Wu, H Y Chiou, T W Wang, Y M Hsueh, I H Wang, C J Chen, T C Lee
Journal: Environmental Health Perspectives (2001)

Arsenic is a notorious environmental toxicant known as both a carcinogen and an atherogen in human beings, but the pathogenic mechanisms are not completely understood. In cell culture studies, trivalent arsenic enhanced oxidative stress in a variety of mammalian cells, and this association may be closely associated with the development of arsenic-related diseases. To investigate the effect of arsenic exposure on oxidative stress in humans, we conducted a population study to determine the relationships of blood arsenic to reactive oxidants and antioxidant capacity at the individual level. We recruited 64 study subjects ages 42-75 years from residents of the Lanyang Basin on the northeast coast of Taiwan, where arsenic content in well water varies from 0 to > or = 3,000 microg/L. We used a chemiluminescence method, with lucigenin as an amplifier for measuring superoxide, to measure the plasma level of reactive oxidants. We used the azino-diethyl-benzthiazoline sulphate method to determine the antioxidant capacity level in plasma of each study subject. We determined arsenic concentration in whole blood by hydride formation with an atomic absorption spectrophotometer. The average arsenic concentration in whole blood of study subjects was 9.60 +/- 9.96 microg/L (+/- SD) with a range from 0 to 46.50 microg/L. The level of arsenic concentration in whole blood of study subjects showed a positive association with the level of reactive oxidants in plasma (r = +0.41, p = 0.001) and an inverse relationship with the level of plasma antioxidant capacity (r = -0.30, p = 0.014). However, we found no significant association (p = 0.266) between levels of plasma reactive oxidants and antioxidant capacity. Our results also show that the lower the primary arsenic methylation capability, the lower the level of plasma antioxidant capacity (p = 0.029). These results suggest that ingestion of arsenic-contaminated well water may cause deleterious effects by increasing the level of reactive oxidants and decreasing the level of antioxidant capacity in plasma of individuals. Persistent oxidative stress in peripheral blood may be a mechanism underlying the carcinogenesis and atherosclerosis induced by long-term arsenic exposure.
Satisfactory resolution of Jessner's lymphocytic infiltration of the skin following treatment with etretinate
Authors: Jacqueline Morgan, Jill Adams
Journal: British Journal of Dermatology (1990)

Journal Article Satisfactory resolution of Jessner's lymphocytic infiltration of the skin following treatment with etretinate Get access Jacqueline Morgan, Jacqueline Morgan Department of Dermatology, Carter Bequest Hospital, Cambridge Road, Middlesbrough, Cleveland TS5 5NH, U.K. Search for other works by this author on: Oxford Academic Google Scholar Jill Adams Jill Adams Department of Dermatology, Carter Bequest Hospital, Cambridge Road, Middlesbrough, Cleveland TS5 5NH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 122, Issue 4, 1 April 1990, Page 570, https://doi.org/10.1111/j.1365-2133.1990.tb14737.x Published: 01 April 1990
Food Sensitivity or Self-Deception?
Authors: Anne Ferguson
Journal: New England Journal of Medicine (1990)

Adverse reactions to ingested food cause a wide variety of conditions, syndromes, symptoms, and diseases1 , 2 for which general descriptive terms such as food intolerance or food sensitivity are useful. These can be applied not only when the reaction has a clearly defined metabolic, pharmacologic, or immunopathologic basis, but also when the mechanism is unknown or disputed. The provoking agent may be a single food or ingredient, but sometimes — particularly in IgE-mediated food allergy — many different foods are involved.Even the most experienced clinician may have difficulty elucidating the exact relation between dietary constituents and the clinical phenomena observed . . .
One hundred twin pairs patch tested with primary irritants*
Authors: ROLF HOLST, HALVOR MÖLLER
Journal: British Journal of Dermatology (2006)

The cutaneous sensitivity to benzalkonium chloride, sodium lauryl sulphate and potash soap was determined in 54 monozygotic and 46 dizygotic twin pairs. Comparing the intra‐pair reaction strength a higher degree of concordance was found among monozygotic than among dizygotic twins, and even more so when monozygotic twins were compared with matched controls.
Emotion is from preparatory brain chaos; irrational action is from premature closure
Authors: Walter J. Freeman
Journal: Behavioral and Brain Sciences (2005)

EEG evidence supports the view that each cerebral hemisphere maintains a scale-free network that generates and maintains a global state of chaos. By its own evolution, and under environmental impacts, this hemispheric chaos can rise to heights that may either escape containment and engender incontinent action or be constrained by predictive control and yield creative action of great power and beauty.
Smoking remains leading cause of premature death in US
Authors: M. McCarthy
Journal: BMJ (2014)

Fifty years after the US surgeon general’s 1964 landmark report that identified smoking as a leading cause of cancer and heart disease, smoking remains the leading cause of premature disease and death in the United States, says a new report issued by the current acting surgeon general, Boris D Lushniak. 1 2

Although the prevalence of cigarette smoking has fallen over the past five decades since the 1964 report from 42% to 18% in 2012, more than 42 million people in the US still smoke, the report …
In vivo stimulation of bone formation by aluminum and oxygen plasma surface-modified magnesium implants
Authors: Hoi Man Wong, Ying Zhao, Vivian Tam, Shuilin Wu, Paul K. Chu, Yufeng Zheng, Michael Kai Tsun To, Frankie K.L. Leung, Keith D.K. Luk, Kenneth M.C. Cheung, Kelvin W.K. Yeung
Journal: Biomaterials (2013)
The Social Transformation of American Medicine
Authors: Lester S. King
Journal: JAMA (1983)

In this important work, sociologist Paul Starr analyzes the relations of the medical profession and society. The book has two separate divisions whose titles reveal their contents. The first part Starr calls "A Sovereign Profession: The Rise of Medical Authority and the Shaping of the Medical System." This is essentially medical history, wherein the sociological dimension predominates. A major concern of sociology is the concept of professionalization. This has to do with the delimitation of classes, as they search for identity, undergo organization, strive for sovereignty and authority as well as status, and come into conflict with other groups. As a generalized sociological concern this process has its standard example in medicine, but the overall concept applies to other groups as well. In an introductory chapter, Starr discusses sovereignty, authority, their relation to economic power, and other general sociological concepts as they have specific reference to medicine. Then he offers
The Treatment of Carbuncle.
Authors: Ralph Chandler
Journal: JAMA (1891)

<h3>To the Editor:</h3> —Under the head of " Practical Notes " in a recent issue, we will all agree with Dr. A. P. Brown in his treatment of carbuncle, as far as crucial incision, use of cocaine, and packing with salicylic acid are concerned; but as for applying a<i>dirty ointment</i>to<i>an open wound</i>the modern surgeon will most decidedly disapprove of. A better procedure would be, first scrub with soap and Hg.Cl<sub>2</sub>1-1,000, anæsthetize with cocaine, incise, curette, swab with tr. iodine, pack with iodoform gauze and apply a<i>moist</i>dressing of Hg.Cl<sub>2</sub>1-5,000 or carbolic acid 1 per cent.; the latter will lessen pain. Remove dressing once in a day or so, and reapply tr. iodine if necessary and proceed as before. 135 Grand Ave., Milwaukee, Wis., Feb. 27, 1891.
Circulating endothelial cells as markers of endothelial dysfunction during hematopoietic stem cell transplantation for pediatric primary immunodeficiency
Authors: Fabien Touzot, Despina Moshous, Guilhem Cros, Pierre Frange, Maryline Chomton, Marie-Louise Frémond, Bénédicte Neven, Marina Cavazzana, Alain Fischer, Stéphane Blanche, Dominique Helley
Journal: Journal of Allergy and Clinical Immunology (2014)
Autism and Lyme Disease
Authors: Robert C. Bransfield, Mason Kuhn
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Minocycline treatment results in reduced oral steroid requirements and suppresses IgE responses in adult asthma
Authors: R. Joks, A. Daoud, G. Taningco, C.J. Gloria, K. Orloff, M.R. Hammerschlag, S. Weiss, M. Gelling, P.M. Roblin, M. Nowakowski, H.G. Durkin
Journal: Journal of Allergy and Clinical Immunology (2005)
US tobacco company admits smoking is addictive
Authors: L. Beecham
Journal: BMJ (1997)

The Liggett Group, the American maker of Chesterfield cigarettes, is the first tobacco group to admit publicly that cigarettes are addictive and cause cancer, heart disease, and emphysema. It will now warn on its cigarette packets that smoking is addictive and can cause cancer.

The company, the smallest of the tobacco companies in the United States, has agreed to settle all claims …
Alcohol Intake Among Women and Its Relationship to Diabetes Incidence and All-Cause Mortality
Authors: Leif Lapidus, Calle Bengtsson, Elisabet Bergfors, Cecilia Björkelund, Fredrik Spak, Lauren Lissner
Journal: Diabetes Care (2005)

OBJECTIVE— The purpose of the study was to explore the predictive value of women’s alcohol habits in relation to incidence of diabetes and all-cause mortality. Special attention was paid to potential confounding factors such as age, heredity, education, socioeconomic group, physical inactivity, smoking, blood pressure, serum lipids, and, in particular, obesity. RESEARCH DESIGN AND METHODS— A longitudinal population study consisting of a representative sample of 1,462 women aged 38–60 started in Göteborg, Sweden, in 1968–1969 monitoring for diabetes and mortality over 32 years. RESULTS— Alcohol intake, expressed as intake of wine, hard liquor, or total grams of alcohol, was significantly negatively associated to 32-year diabetes incidence independent of age. However, the apparently protective effect of the alcohol variables was attenuated when BMI was included as a covariate. The inverse relationship between wine intake and diabetes did not remain after adjustment for physical activity or socioeconomic group. Beer and wine intake were significantly negatively associated to mortality. Increase of alcohol intake between the examination in 1968–1969 and 1980–1981 was significantly inversely related to the mortality between 1980–1981 and 2000–2001 and independent of all covariates. No relationship was observed between an increase in alcohol intake and diabetes incidence. However, after adjustment for age, family history, and basal alcohol consumption altogether, a significant inverse relationship was observed between increase of alcohol and diabetes incidence. CONCLUSIONS— The initially significant inverse associations observed between alcohol and diabetes as well as mortality were dependent on a number of confounding factors, of which BMI seems to be the most important.
Lost Potential in Medical Manpower
Authors: M. J. R. Bastable, A. Beardwell, E. Besterman, M. Cash, E. Coates, M. Corbett, J. Colston, P. Cracroft, U. Davies, C. Davies, P. Edwards, R. Edelston, P. Emerson, C. Feldman, B. Goetzee, H. Goodman, S. Hepton, S. Jones, L. Lessof, U. H. Paterson, P. Last, J. Pritchard, K. Rhodes, M. Sidaway
Journal: BMJ (1964)

In respect of in-patients during 1961 in the Wessex Region there were 17,307 patients discharged from 892 beds in general medical wards, and 2,874 discharges from 607 beds in chest hospitals.These figures are not comparable because some of the chest hospital beds are necessarily and properly used for long-stay patients (e.g., tuberculosis, respiratory invalids, or lung-cancer cases),