tbuckley/cabot-search huggingface dataset:
Sterility of Blood Collection Tubes
Authors: Theodore J. Medrek, B. C. Wooley
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 November 1977Sterility of Blood Collection TubesTHEODORE J. MEDREK, M.D., B. C. WOOLEY, PH.D.THEODORE J. MEDREK, M.D.Search for more papers by this author, B. C. WOOLEY, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-5-631_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Data in a recent article, "The Microbiology of Evacuated Blood Collection Tubes" (Ann Intern Med86:186-188, 1977), indicated that about 9% of the sterile, yellow-stoppered Vacutainer tubes tested contained viable bacteria. The sterility of yellow-stoppered Vacutainer tubes manufactured by Becton, Dickinson and Company is assured through an extensive control program. Therefore, we were disturbed and very concerned when we were informed in July 1976 that laboratories had detected bacterial contamination in some of our yellow-stoppered tubes. We then initiated an extensive investigation. This letter makes public the results of our investigation so that readers of the article... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1977Volume 87, Issue 5Page: 631-632KeywordsBacteriaBloodInfertilityMicrobiologyVacutainer Issue Published: 1 November 1977 PDF downloadLoading ...
Effect of Experimental Pneumococcal Meningitis on Respiration and Circulation in the Rabbit
Authors: Malcolm R. Sears, J. Morgan O'Donoghue, H. Kenneth Fisher, Harry N. Beaty
Journal: Journal of Clinical Investigation (1974)

Pathophysiological studies in bacterial meningitis in man have been limited by clinical variability and the necessity for immediate therapy. After the development of a reliable animal model of pneumococcal meningitis, we studied respiration and circulation in 25 anesthetized New Zealand white rabbits during untreated pneumococcal meningitis and in 33 healthy controls. In meningitis, we found increased lactic acid in cerebrospinal fluid (CSF). Increased ventilation, perhaps due to CSF lactic acid accumulation, resulted in respiratory alkalosis; the concomitant lowering of Pco(2) acted as a homeostatic mechanism to restore pH toward normality in the CSF. Hyperventilation increased with the duration of the illness. Cardiac output was also increased with decreased peripheral vascular resistance but with only slight reduction in mean systemic and pulmonary arterial pressures. In the final hour of life, peripheral vascular resistance fell further; ventilation declined and then abruptly ceased while cardiac activity continued. Lactic acid accumulation in the CSF, found in both experimental and human pneumococcal meningitis, may cause the hyperventilation found in this disease and may contribute to death.
Double-blind Cross-over Study of Ketoprofen and Ibuprofen in Management of Rheumatoid Arthritis
Authors: S. B. Mills, M. Bloch, F. E. Bruckner
Journal: BMJ (1973)

A double-blind cross-over study of ketoprofen (Orudis) 150 mg daily and ibuprofen (Brufen) 1,200 mg daily was carried out in 35 outpatients with rheumatoid arthritis. Results suggest that analgesic and anti-inflammatory activity of ketoprofen is superior to that of ibuprofen. Significantly greater pain relief (P &lt; 0·05) and reduction in joint circumference (P &lt; 0·01) was obtained with ketoprofen than with ibuprofen. Side effects of the drugs were comparable and not serious.
Propranolol, Digoxin, and Angina Pectoris
Authors: S. FISCH
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 February 1976Propranolol, Digoxin, and Angina PectorisS. FISCH, M.D., PH.D., F.A.C.P.S. FISCH, M.D., PH.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-2-219 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: It is a pity that so much time and excellent effort was expended by Crawford and associates (Ann Intern Med 83:449-455, 1975) in the conception and execution of their work on propranolol, digoxin, and angina pectoris, to have the study nullified by the retention of investigational bias.Had these investigators followed a double-blind randomized pattern rather than one of fixed sequence in drug administration the conclusions of this otherwise beautiful study would have been unassailable. The problem of digoxin persistence on cross-over could have been eliminated by lengthening each period to allow reasonably for 2 weeks of...Reference1. CRAWFORD M, LEWINTER M, and O'ROURKE R: Combined propranolol and digoxin therapy in angina pectoris. Ann Intern Med 83:449-555, 1975 LinkGoogle Scholar1. MILLER R, OLSON H, and AMSTERDAM E: Propranolol-withdrawal rebound phenomenon: exacerbation of coronary events after abrupt cessation of antianginal therapy. N Engl J Med 293: 416, 1975 CrossrefMedlineGoogle Scholar2. ALDERMAN E, COLTART D, and WETTACH G: Coronary artery syndromes after sudden propranolol withdrawal. Ann Intern Med 81:625-627, 1974 LinkGoogle Scholar3. DIAZ R, SOMBERG J, and FREEMAN E: Withdrawal of propranolol and myocardial infarction (letter). Lancet 1:1068, 1973 CrossrefMedlineGoogle Scholar1. MILLER R, OLSON H, and AMSTERDAM E: Propranolol-withdrawal rebound phenomenon: exacerbation of coronary events after abrupt cessation of antianginal therapy. N Engl J Med 293:416, 1975 CrossrefMedlineGoogle Scholar2. ALDERMAN E, COLTART D, and WETTACH G: Coronary artery syndromes after sudden propranolol withdrawal. Ann Intern Med 81:625-621, 1974 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: S. FISCH, M.D., PH.D., F.A.C.P. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntianginal drugs 1 February 1976Volume 84, Issue 2Page: 219-220KeywordsAnginaDrug administration ePublished: 1 December 2008 Issue Published: 1 February 1976 PDF downloadLoading ...
Heart transplantation in heart failure: The prognostic importance of body mass index at time of surgery and subsequent weight changes
Authors: Andrew L. Clark, Christoph Knosalla, Emma Birks, Matthias Loebe, Constantinos H. Davos, Sui Tsang, Abdissa Negassa, Magdi Yacoub, Roland Hetzer, Andrew J.S. Coats, Stefan D. Anker
Journal: European Journal of Heart Failure (2007)
One NHS reorganisation too many: time to move on
Authors: Sarah Wilson
Journal: BMJ (2006)

M ost British doctors are not affected by NHS reorganisations. They manage to concentrate on caring for their patients, despite the surrounding upheaval. Many GPs and consultants don't know what the current NHS structure is or what a primary care trust or strategic health authority does, and to them it probably doesn't matter. It is different for public health doctors: they are invariably affected and are often required to move into a new organisation. Many years ago a wise medical director told me that as a “punishment for joining NHS management” public health doctors have to regularly reapply for their jobs.

I was a director of public health in three health authorities, none of which now exist. I always believed that the value of public health skills and knowledge, once recognised, would guarantee that boards and colleagues embrace and implement good public health practice. Doing so became harder and harder over the past 10 years.

> Contestability confronted professional protectionism 

In 2002 we implemented the proposals in the NHS's Shifting the Balance of Power policy in response to concerns that patients, the public, and frontline clinicians had too little …
Barrett-esophagus Following Total Gastrectomy: A Contribution to it's Pathogenesis
Authors: W. Meyer, F. Vollmar, W. Bär
Journal: Endoscopy (1979)

We have undertaken esophagoscopy œ to 17 œ years after surgery in 20 patients with a total gastrectomy and an esophago-jejunal anastomosis. In 5 cases we found a complete columnar lining of the distal esophagus (Barrett-esophagus). 2 other cases showed a multilocular columnar epithelium. One case with a Barrett-esophagus had endoscopy before surgery, and it could be proved that the columnar lining developed after surgery. We suspect that it was the same in the remaining cases. All examined patients, except one, showed an erosive esophagitis of varying severity. These observations support the current view that the columnar lined esophagus is usually an acquired one. The pathogenesis is not completely clear, but reflux of digestive juices destroying the squamous epithelium and impairing healing is the condition for columnar lining. The observations on patients with total gastrectomy prove that it must not necessarily be gastric juice. The very urgent question of the origin of columnar lining cannot be answered at present.
Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity
Authors: Kathleen D. Metzler, Tobias A. Fuchs, William M. Nauseef, Dominique Reumaux, Joachim Roesler, Ilka Schulze, Volker Wahn, Venizelos Papayannopoulos, Arturo Zychlinsky
Journal: Blood (2010)
STREPTOCOCCI IN AIR AS AN INDICATOR OF NASOPHARYNGEAL CONTAMINATION
Authors: JOHN C. TORREY
Journal: JAMA (1941)

With the introduction of the Wells Air Centrifuge,1a renewed interest has developed in the bacteriologic examination of air, particularly in reference to its streptococcic content under various environmental conditions. The studies, including some on schools, theaters, subways, railway cars, textile factories and hospitals, have been conducted largely in New York, Boston and Iowa City.2Our investigations, carried out in a department store3which is the largest and perhaps at times the most crowded in the world, constitute an attempt to correlate the density of crowds with the degree of bacterial pollution of the air, in relation not only to total bacterial counts but especially to the numbers of streptococci of nasopharyngeal origin, to determine seasonal variations in respect to such data and to plot the prevalence rate for disabling colds among the employees in relation to the numbers of streptococci in the air during the course
Montreal General Hospital
Authors: W. Storrar
Journal: BMJ (1954)

Great developments have taken place in Canada in the last decade, and with the large increase in population more hospital beds have become necessary.In the City of Montreal alone 3,000 hospital beds are being built at present to meet the demands of this rapidly expanding cosmopolitan city.The largest single hospital building project in Miontreal, in fact in Canada, now being under- taken is the con- struction of the new buildings of the Mdontreal General Hospital.
Clinical performance of the Nevisense system in cutaneous melanoma detection: an international, multicentre, prospective and blinded clinical trial on efficacy and safety
Authors: J. Malvehy, A. Hauschild, C. Curiel‐Lewandrowski, P. Mohr, R. Hofmann‐Wellenhof, R. Motley, C. Berking, D. Grossman, J. Paoli, C. Loquai, J. Olah, U. Reinhold, H. Wenger, T. Dirschka, S. Davis, C. Henderson, H. Rabinovitz, J. Welzel, D. Schadendorf, U. Birgersson
Journal: British Journal of Dermatology (2014)

Even though progress has been made, the detection of melanoma still poses a challenge. In light of this situation, the Nevisense electrical impedance spectroscopy (EIS) system (SciBase AB, Stockholm, Sweden) was designed and shown to have the potential to be used as an adjunct diagnostic tool for melanoma detection.To assess the effectiveness and safety of the Nevisense system in the distinction of benign lesions of the skin from melanoma with electrical impedance spectroscopy.This multicentre, prospective, and blinded clinical study was conducted at five American and 17 European investigational sites. All eligible skin lesions in the study were examined with the EIS-based Nevisense system, photographed, removed by excisional biopsy and subjected to histopathological evaluation. A postprocedure clinical follow-up was conducted at 7 ± 3 days from the initial measurement. A total of 1951 patients with 2416 lesions were enrolled into the study; 1943 lesions were eligible and evaluable for the primary efficacy end point, including 265 melanomas - 112 in situ and 153 invasive melanomas with a median Breslow thickness of 0·57 mm [48 basal cell carcinomas (BCCs) and seven squamous cell carcinomas (SCCs)].The observed sensitivity of Nevisense was 96·6% (256 of 265 melanomas) with an exact one-sided 95% lower confidence bound estimated at 94·2% and an observed specificity of 34·4%, and an exact two-sided 95% confidence bound estimated at 32·0-36·9%. The positive and negative predictive values of Nevisense were 21·1% and 98·2%, respectively. The observed sensitivity for nonmelanoma skin cancer was 100% (55 of 48 BCCs and seven SCCs) with an exact two-sided 95% confidence bound estimated at 93·5-100·0%.Nevisense is an accurate and safe device to support clinicians in the detection of cutaneous melanoma.
Clarifying electron micrograph labeling
Authors: Charles Marwick
Journal: JAMA (1986)

Two years ago, a<i>JAMA</i>news article on acquired immunodeficiency syndrome (AIDS) was accompanied by three electron micrographs labeled HTLV-III—human T-cell lymphotropic virus (<i>JAMA</i>[MEDICAL NEWS] 1984;251:2901-2909). Provided by the National Cancer Institute, they are identical to those published originally by institute investigators headed by Robert C. Gallo, MD (<i>Science</i>1984;224:503-505). It now turns out that the electron micrographs are of a cell culture infected, not with HTLV-III, but with the lymphadenopathy-associated virus (LAV) isolated early in 1983 by Pasteur Institute investigators headed by Luc Montagnier, PhD. A specimen of the virus was sent to Gallo and his associates by the Paris group in September of that year. Gallo and his associates could not get the lymphadenopathy-associated virus to grow in culture for more than a brief period. Nevertheless, they had electron micrographs made of such examples of viral replication as they were able to obtain in order to show
Notes of a Case of Extra-Uterine Pregnancy: Discharge of F tus Per Rectum: Stricture of Rectum and Colotomy
Authors: H. J. Benham
Journal: BMJ (1876)

A better form i that made of vulcanite, which is fastened by means of a screw, but it is freg,uently broken by being overscrewed.The discharges get into the interstices of the screw, and it cannot be released, and often the adjacent hairs get entangled, giv'ing rise to con- siderble pain; and so Zwanke's pessary with many has fallen into disuse.to obviate thete objections, I have contrived a form of Zwanke's pessary, which has been manufactured for me, and regis- tered by Messrs. Arnold and Sons of Smiithfield, and it has already proved to be a very useful pessary.It is shown in the accompanying illustration.The upper part is made of vulcanite, and is extremely cleanly, liglht, and durable.The lower portion or feet, employed for locking, is made of metal.Directly these feet come into contact, with the slightest pressure they lock, and they are as easily released by pressing with one finger uponthe spnrng, and at the same time pushing the curved extremity down with the thumb.It may be suggested, that this portion will give pain by pressing externally, but this in pmctice will be found not to be the case.The patient walks about and sits down with perfect comfort.The expense-a very important item-is very little more
Eosinophilia-myalgia syndrome in L-tryptophan-exposed patients
Authors: M. L. Kamb
Journal: JAMA (1992)

To study the incidence of eosinophilia-myalgia syndrome, the risk factors associated with the syndrome, and the clinical spectrum of illness associated with L-tryptophan use in an exposed population.Retrospective cohort and nested case-control studies of risk factors for eosinophilia-myalgia syndrome using inpatient and outpatient chart reviews, telephone interviews, and in-person patient interviews. Descriptive study of clinical course of L-tryptophan users.Office practice of one psychiatrist based in a small city (population 43,467) in South Carolina.Eligible subjects were all patients from the practice who used L-tryptophan during the 1989 study interval. Of these, 418 (87%) were interviewed.Clinical spectrum of illness associated with L-tryptophan use, including definite and possible cases of eosinophilia-myalgia syndrome.Among the 418 interviewed L-tryptophan users, we identified 47 definite cases (11%) and 68 possible cases (16%) of eosinophilia-myalgia syndrome, most of which involved patients who were using one retail brand of L-tryptophan (brand A). Among the 157 brand A users, we identified 45 definite cases (29%) and 36 possible cases (23%) of eosinophilia-myalgia syndrome, and the risk for the syndrome increased as the brand A dose increased. Fifty percent (19 of 38) of those using more than 4000 mg/day developed definite eosinophilia-myalgia syndrome, and 84% (32 of 38) developed either definite or possible eosinophilia-myalgia syndrome. On multivariate analysis, risk for definite eosinophilia-myalgia syndrome was associated with brand A dose and age of the patient; however, gender, race, and use of other medications were not associated with the syndrome.These results suggest that many people exposed to the agent causing eosinophilia-myalgia syndrome may develop illness, and dose of presumably contaminated L-tryptophan is the single most important predictor of eosinophilia-myalgia syndrome. The broad range of signs and symptoms reported by patients using L-tryptophan illustrates that a strict case definition may identify only about half of those affected.
Isolation by immobilized artificial membrane chromatography (IAM-PC) and partial identification of potent biliary cholesterol crystallization inhibitor proteins
Authors: R SECKNUS
Journal: Hepatology (1995)

Intense inflammatory response and an anti-angiogenic state have been implicated in the pathogenesis of preeclampsia. Here, we investigated this hypothesis evaluating the serum concentrations of CXCL10/IP-10, sFlt-1, and PlGF in women with early-onset preeclampsia. CXCL10/IP-10 was measured by Cytometric Bead Array. sFlt-1 and PlGF were measured by automated electrochemiluminescence immunoassay. The median serum concentration of CXCL10/IP-10 was 109.5 pg/mL in preeclamptic women, as compared with 52.28 pg/mL in the controls (P = 0.0028). The mean serum level of sFlt-1 was 13,636 pg/mL in preeclamptic women, as compared with 2020 pg/mL in the controls (P < 0.0001). PlGF levels were significantly lower in women with preeclampsia.
Should Clinicians Encourage Smoking Cessation for Every Patient Who Smokes?
Authors: Michael C. Fiore, Timothy B. Baker
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Building a second brain in the bowel
Authors: Marina Avetisyan, Ellen Merrick Schill, Robert O. Heuckeroth
Journal: Journal of Clinical Investigation (2015)

The enteric nervous system (ENS) is sometimes called the "second brain" because of the diversity of neuronal cell types and complex, integrated circuits that permit the ENS to autonomously regulate many processes in the bowel. Mechanisms supporting ENS development are intricate, with numerous proteins, small molecules, and nutrients that affect ENS morphogenesis and mature function. Damage to the ENS or developmental defects cause vomiting, abdominal pain, constipation, growth failure, and early death. Here, we review molecular mechanisms and cellular processes that govern ENS development, identify areas in which more investigation is needed, and discuss the clinical implications of new basic research.
Patch test concentrations of grotan BK
Authors: M.G.C. D ahl
Journal: British Journal of Dermatology (1981)

Journal Article Patch test concentrations of grotan BK Get access M.G.C. ahl D M.G.C. ahl D University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NEI 4LP Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 104, Issue 5, 1 May 1981, Page 607, https://doi.org/10.1111/j.1365-2133.1981.tb08182.x Published: 01 May 1981
Women in Medicine-Reply
Authors: Carlotta M. Rinke
Journal: JAMA (1982)

<h3>In Reply.—</h3> I appreciate Dr Bryan's comments and am happy to reply to several points she has raised. Dr Bryan states "that women can behave both competently and assuredly without losing their femininity or become emasculating is demonstrated constantly by many women physicians." I certainly hope such is the case, but the achievement of this milestone takes considerable energy, both psychological and professional. Successfully integrating a feminine mode of being into a paternalistic, authoritative male profession is not an insurmountable obstacle, but it is a definite conflict that defers creative energies away from professional matters. Since men comprise and define the medical community, the scientific and philosophical principles they formulate will be based on male stereotypes. It is difficult for a woman to be recognized as a professional peer. One way of dealing with the problem is to relinquish one's feminine demeanor and assume the traits of the male stereotype.