tbuckley/cabot-search huggingface dataset:
Sex and the Church.
Authors: E James
Journal: BMJ (1978)

As the ideal of love is revealed by God to Christians it encompasses both the human body and the spiritual life.   and sexuality are inseparable paths to knowing God and the divinity of humanity.  In recent years the Church of England has failed to address the social mores and sexual behavior that characterizes a modern society unfettered by birth control and uncertain of sexualitys wider meanings.  A new report Marriage and the Churchs Task reaffirms the connections between spiritual and carnal love in homosexual and heterosexual relationships.  The report recognizes marriage as an emotional spiritual habitual and personal bond based on mutual love and the promise of fidelity.   counseling is acknowledged as an acquired skill not bestowed by ordination.   counseling is a responsibility of the Church since it prepares many people for marriage.  Priests and ministers should be trained to counsel couples before and after marriage.
Acral self-healing collodion baby: report of a new clinical phenotype caused by a novel<i>TGM1</i>mutation
Authors: J. Mazereeuw-Hautier, K. Aufenvenne, C. Deraison, B. Ahvazi, V. Oji, H. Traupe, A. Hovnanian
Journal: British Journal of Dermatology (2009)

A minority of collodion babies, called 'self‐healing collodion babies', heal spontaneously. We describe a novel clinical phenotype of acral self‐healing collodion baby caused by a new TGM1 mutation. The proband, born to healthy parents, presented at birth as a collodion baby strictly localized to the extremities. The skin condition returned to normal at the age of 3 weeks. The older sister was born as a generalized collodion baby; the condition then developed into lamellar ichthyosis. Molecular analysis of TGM1 revealed three novel mutations in the family. The proband was compound heterozygous for the p.Val359Met and p.Arg396His mutations, whereas the older sister was compound heterozygous for p.Arg396His and a deletion mutation c.1922_1926+2delGGCCTGT. Structural modelling of the p.Val359Met mutation suggested a minor disruption of the protein structure, whereas a modification of protein–protein interaction was predicted for p.Arg396His. These predictions corroborated the analysis of recombinant transglutaminase (TGase)‐1 proteins carrying the p.Val359Met and p.Arg396His mutations. Both showed decreased levels of protein expression: p.Val359Met displayed residual activity (12·8%), while p.Arg396His caused a dramatic loss of activity (3·3%). These observations demonstrate for the first time that TGM1 mutations can be associated with acral self‐healing collodion baby, and expand the clinical spectrum of TGase‐1 deficiency.
Computer interrogation of patients.
Authors: H C Price
Journal: BMJ (1976)

reported to arrest haemorrhage from oesophageal varices in a proportion of cases for periods ranging from hours to months,' --6 but haemorrhage recurred in some patients when the cannula was removed.2 46The effectiveness of thoracic duct cannulation for bleeding oesophageal varices is still a controversial, matter.In spite of this, I think that the policy that should be adopted is to perform cannulation of the thoracic duct in patients not fit for major emergency operation.If this minor palliative procedure succeeds in preventing further bleeding the patient can be better prepared for a portacaval shunt operation that can be conducted a few days after his general condition has improved.
Hunting and Trapping the Vascular Endothelial Growth Factor
Authors: Afshin Dowlati
Journal: Journal of Clinical Oncology (2009)

the angiogenic response in HIF-1alpha–deficient colon cancer cells. Nat Med 11:992-997, 2005 16. Batchelor TT, Sorensen AG, di Tomaso E, et al: AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature, and alleviates edema in glioblastoma patients. Cancer Cell 11:83-95, 2007 17. Willett CG, Duda DG, di Tomaso E, et al: Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: A multidisciplinary phase II study. J Clin Oncol 27:3020-3026, 2009 18. Zhu AX, Sahani DV, Duda DG, et al: Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: A phase II study. J Clin Oncol 27:3027-3035, 2009 19. Shojaei F, Wu X, Malik AK, et al: Tumor refractoriness to anti-VEGF treatment is mediated by CD11b Gr1 myeloid cells. Nat Biotechnol 25:911-920, 2007 20. Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-2342, 2004 21. Miller K, Wang M, Gralow J, et al: Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357:2666-2676, 2007 22. Giantonio BJ, Catalano PJ, Meropol NJ, et al: Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 25:1539-1544, 2007 23. Heymach JV, Paz-Ares L, De Braud F, et al: Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non–small-cell lung cancer. J Clin Oncol 26:5407-5415, 2008 24. Hanrahan EO, Ryan AJ, Mann H, et al: Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non–small-cell lung cancer. Clin Cancer Res 15:3600-3609, 2009
Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment
Authors: Carlos Perez-Sanchez, Patricia Ruiz-Limon, Maria Angeles Aguirre, Maria Laura Bertolaccini, Munther A. Khamashta, Antonio Rodriguez-Ariza, Pedro Segui, Eduardo Collantes-Estevez, Nuria Barbarroja, Husam Khraiwesh, Jose Antonio Gonzalez-Reyes, Jose Manuel Villalba, Francisco Velasco, Maria Jose Cuadrado, Chary Lopez-Pedrera
Journal: Blood (2012)
Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus
Authors: John A Wagner, Thomas Reynolds, Mary Lynn Moran, Richard B Moss, Jeffrey J Wine, Terence R Flotte, Phyllis Gardner
Journal: The Lancet (1998)

Cystic fibrosis is a common, lethal, genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), and it is an attractive target for gene therapy. Adeno-associated virus (AAV) is a naturally replication-deficient single-stranded DNA parvovirus. Preclinical studies showed that CFTR transcripts and protein can be detected up to 6 months after transduction with an AAV-CFTR vector, 1 Flotte TR Afione SA Conrad C et al. Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proc Natl Acad Sci USA. 1993; 90: 10613-10617 Crossref PubMed Scopus (443) Google Scholar with no pathogenicity, 2 Conrad CK Allen SS Afione SA et al. Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung. Gene Ther. 1996; 3: 658-668 PubMed Google Scholar suggesting that AAV performs well as a gene transfer vehicle for CFTR. The maxillary sinuses are attractive for evaluating new treatments of cystic fibrosis because they have ion-transport systems and microbiology similar to those of the lower respiratory tract. 3 Moss RB King VV Management of sinusitis in cystic fibrosis by endoscopic surgery and serial antimicrobial lavage: reduction in recurrence requiring surgery. Arch Otolaryngol Head Neck Surg. 1995; 121: 566-572 Crossref PubMed Scopus (121) Google Scholar , 4 Wine JJ King VV Lewiston NJ Method for rapid evaluation of topically applied agents to cystic fibrosis airways. Am J Physiol. 1991; 261: L218-L221 PubMed Google Scholar Recurrence of maxillary sinusitis may prove to be a surrogate for infectious exacerbations characteristic of cystic fibrosis lung disease.
Gallium-positive Thrombophlebitis
Authors: WILLIAM H. McCUSKEY, KATHLEEN L McDONALD
Journal: Clinical Nuclear Medicine (1992)

A 77-year-old man underwent whole body Ga-67 imaging for pain in his right leg. Gallium activity was present within the deep venous system of the right thigh and calf. A Tc-99m RBC venogram of the lower extremities revealed thrombophlebitis.
BLOCKADE OF ALDOSTERONE PRODUCTION AS A NOVEL APPROACH TO THE MANAGEMENT OF HIGH BLOOD PRESSURE: EFFICACY AND TOLERABILITY OF THE ALDOSTERONE SYNTHASE INHIBITOR LCI699 IN PATIENTS WITH STAGE 1-2 HYPERTENSION
Authors: William B. White, David A. Calhoun, Henry Krum, Weinong Guo, Angelo J. Trapani, Martin Lefkowitz, Joel Menard
Journal: Journal of the American College of Cardiology (2010)
Assessment of US pathway for approving medical devices for rare conditions
Authors: T. J. Hwang, D. Carpenter, A. S. Kesselheim
Journal: BMJ (2014)

An FDA program established in the 1990s made it easier for manufacturers to get devices for rare diseases into use. <b>Thomas J Hwang and colleagues</b> examine how the program has been used and what can be learnt for US and European device regulation
Factors affecting colectomy rate in ulcerative colitis: an epidemiologic study.
Authors: C E Leijonmarck, P G Persson, G Hellers
Journal: Gut (1990)

Factors affecting colectomy rate were studied in a retrospective population based series of 1586 patients with ulcerative colitis, in Stockholm County during 1955-84. Five hundred and sixty eight patients (36%) had total colitis at diagnosis, 603 patients (38%) left sided colitis, and 397 patients (25%) proctitis. During a median period of observation of 13 years 514 patients were treated by colectomy. The five, 10, and 25 year cumulative colectomy rate were 20% (CI 18-22%), 28% (CI 26-30%), and 45% (CI 41-49%) respectively. The main factor affecting the colectomy rate was the extent of disease at diagnosis. Patients with total colitis showed a five, 10, and 25 year cumulative colectomy rate of 32% (CI 28-36%), 42% (CI 38-46%), and 65% (CI 58-72%) respectively. Ten per cent of the 1586 patients had a colectomy during the first year after diagnosis, 4% during the second year and 1% during subsequent years. The age at diagnosis and sex did not affect the cumulative colectomy rate. Elective colectomy was performed in 322 cases (63%) and acute colectomy in 192. The duration of disease before colectomy fell during the study period due to a more standardised criteria for colectomy in severe attacks. One hundred and twenty nine (66%) of the acute colectomies were performed within two years from diagnosis.
Cortisol Secretion in Nelson Syndrome
Authors: Peter D. Papapetrou
Journal: JAMA (1975)

In two patients who were severely pigmented (Nelson syndrome) following bilateral adrenalectomy for Cushing syndrome, symptoms of hyper-cortisolism developed while they were receiving only physiologic steroid replacement. Cortical assays proved that endogenous cortisol production had not been obliterated. Even after total adrenalectomy, steroid measurement should be performed to guard against adrenocortical excess.
Short-Course Chemotherapy with TMC207 and Rifapentine in a Murine Model of Latent Tuberculosis Infection
Authors: Tianyu Zhang, Si-Yang Li, Kathy N. Williams, Koen Andries, Eric L. Nuermberger
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB) is an emerging global health threat. Proper management of close contacts of infectious patients is increasingly important. However, no evidence-based recommendations for treating latent TB infection (LTBI) after MDR/XDR-TB exposure (DR-LTBI) exist. An ultrashort regimen for LTBI caused by drug-susceptible strains (DS-LTBI) is also desirable. TMC207 has bactericidal and sterilizing activity in animal models of TB and improves the activity of current MDR-TB therapy in patients.The objective of this study was to determine whether TMC207 might enable short-course treatment of DR-LTBI and ultrashort treatment of DS-LTBI.Using an established experimental model of LTBI chemotherapy in which mice are aerosol-immunized with a recombinant bacillus Calmette-Guérin vaccine before low-dose aerosol infection with Mycobacterium tuberculosis, the efficacy of TMC207 alone and in combination with rifapentine was compared with currently recommended control regimens as well as once-weekly rifapentine + isoniazid and daily rifapentine ± isoniazid.Outcomes included monthly lung colony-forming unit counts and relapse rates.Lung colony-forming unit counts were stable at about 3.75 log(10) for up to 7.5 months postinfection in untreated mice. Rifamycin-containing regimens were superior to isoniazid monotherapy. TMC207 exhibited sterilizing activity at least as strong as that of rifampin alone and similar to that of rifampin + isoniazid, but daily rifapentine +/- isoniazid was superior to TMC207. Addition of TMC207 to rifapentine did not improve the sterilizing activity of rifapentine in this model.TMC207 has substantial sterilizing activity and may enable treatment of DR-LTBI in 3-4 months.
Human leucocyte antigen class II associations in chronic idiopathic urticaria
Authors: B F O'Donnell, C M O'Neill, D M Francis, N Niimi, R M Barr, R J Barlow, A Kobza Black, K I Welsh, M W Greaves
Journal: British Journal of Dermatology (1999)

The major histocompatibility complex (MHC) acts as a marker for self during T‐cell ontogeny and is associated with the pathogenesis of many autoimmune diseases. Recent investigations have shown about 30% of patients with chronic idiopathic urticaria (CIU) have IgG autoantibodies against the high‐affinity IgE receptor, FcεRI, or IgE. A link between MHC class II alleles and CIU has not been reported previously. DNA was extracted from blood of 100 Caucasian patients with CIU, and the MHC class II type determined using the polymerase chain reaction with sequence‐specific primers, testing for DRB and DQB1 alleles. The frequency of alleles in CIU patients was compared with that found in 603 controls. Further human leucocyte antigen (HLA) typing on patient subsets, classified by the patients' responses to intradermal injection of autologous serum and their serum‐induced histamine release from basophil leucocytes of healthy donors, was undertaken. HLA DRB1*04 (DR4) and its associated allele, DQB1*0302 (DQ8), are raised in CIU patients compared with a control population (P = 2 × 10−5 and P = 2 × 10−4, respectively). HLA DRB1*15 (DR15) and its associated allele, DQB1*06 (DQ6), are significantly less frequently associated with CIU. The HLA DRB1*04 association is particularly strong (corrected P = 3.6 × 10−6) for patients whose serum has in vivo and in vitro histamine‐releasing activity. HLA class II typing is consistent with the concept that CIU is a heterogeneous disease, and supports an autoimmune pathogenesis in a subset of patients.
Functional Asplenia in Sezary Syndrome
Authors: SUPPIAH BALACHANDRAN, RAJENDRA KUMAR, TSENG-TONG KUO
Journal: Clinical Nuclear Medicine (1980)

A case of functional asplenia revealed by radiocolloid scanning is reported in a patient suffering from Sezary syndrome, a lymphoma of cutaneous origin. Heavy, diffuse sinusoidal infiltration of the spleen by the Sezary cells appears to be responsible for the functional asplenia in this case.
Relation between myocardial infarct location and stroke
Authors: Monty M. Bodenheimer, Deborah Sauer, Babar Shareef, Mary W. Brown, Joseph L. Fleiss, Arthur J. Moss
Journal: Journal of the American College of Cardiology (1994)

Objectives. We sought to compare the likelihood of stroke in patients with anterior versus nonanterior myocardial infarction. Background. The association between anterior infarction and left ventricular thrombus has led to the assumption that embolization from thrombi is an important cause of stroke in patients with anterior infarction. We hypothesized that if anterior infarction is a cause of left ventricular thrombi, the number of strokes should be disproportionately higher in patients with anterior than nonanterior infarction. Methods. We performed a retrospective analysis of 2,466 patients randomized from day 3 to day 15 after infarction as part of a multicenter placebo-controlled study of diltiazem to prevent cardiac death or myocardial infarction. Any acute focal cerebral disorder resulting in localizing findings characterized as a stroke or transient ischemic attack was considered an event. Results. Of 91 events during a follow-up period of 12 to 52 months, 23 (3.2%) occurred in 724 patients with an anterior and 68 (3.9%) in 1,742 patients with a nonanterior myocardial infarction (relative risk 0.81; 95% confidence interval 0.51 to 1.30). Power analysis revealed that the negativity of the study was not the result of inadequate sample size. Life table analysis showed no difference in cumulative event rate (p = 0.42) according to site of infarction. Cox regression analysis showed that of 10 clinical covariates, only systolic blood pressure was predictive of stroke (p < 0.001). The use of warfarin did not contribute to the model. Finally, the addition of site of infarction (anterior vs. nonanterior) did not contribute significantly to the Cox model. Conclusions. Although there is a significant incidence of stroke after acute myocardial infarction, there is no relation between the occurrence of stroke and site of infarction. These data do not support the presumed causal relation between anterior myocardial infarction, thrombus and stroke.
Levosimendan in acute heart failure following primary percutaneous coronary intervention‐treated acute ST‐elevation myocardial infarction. Results from the LEAF trial: a randomized, placebo‐controlled study
Authors: Trygve Husebye, Jan Eritsland, Carl Müller, Leiv Sandvik, Harald Arnesen, Ingebjørg Seljeflot, Arild Mangschau, Reidar Bjørnerheim, Geir Øystein Andersen
Journal: European Journal of Heart Failure (2013)
The role of front-line anthracycline-containing chemotherapy regimens in peripheral T-cell lymphomas
Authors: R Briski, A L Feldman, N G Bailey, M S Lim, K Ristow, T M Habermann, W R Macon, D J Inwards, J P Colgan, G S Nowakowski, M S Kaminski, T E Witzig, S M Ansell, R A Wilcox
Journal: Blood Cancer Journal (2014)

Peripheral T-cell lymphomas (PTCLs) are a heterogenous group of aggressive non-Hodgkin’s lymphomas that are incurable in the majority of patients with current therapies. Outcomes associated with anthracycline-based therapies are suboptimal, but remain the standard of care for most patients, even though the benefits of this approach remain uncertain. This study retrospectively examined outcomes in a cohort of North American PTCL patients treated with both anthracycline- and nonanthracycline-containing regimens. The incorporation of anthracycline-containing regimens was associated with improved progression-free survival (PFS) and overall survival (OS). Patients treated with nonanthracycline-containing regimens were more likely to have high-risk features and were less likely to undergo high-dose therapy and stem cell transplantation. However, anthracycline use remained an independent predictor of improved PFS and OS when adjusting for these confounding variables. Anthracycline-based regimens and consolidation with high-dose therapy and autologous stem cell transplantation in appropriately selected patients remains a viable option for patients unable to participate in a clinical trial. Long-term disease-free survival is not optimal, highlighting the need for an improved understanding of disease pathogenesis, and the development of novel therapeutic strategies.
Ectopic pregnancy in Finland 1967-83: a massive increase.
Authors: J I Makinen
Journal: BMJ (1987)

<h3>Background</h3> Previous studies have suggested that anterior communicating artery (ACoA) microaneurysms (&lt;4 mm) were associated with a higher rate of peri-procedure complications when compared to ACoA aneurysms that were 4 mm or larger. We aimed to evaluate the outcomes of patients with unruptured ACoA aneurysms according to aneurysm size in a large, contemporary registry. <h3>Methods</h3> We reviewed the prospective, multicenter SMART registry to identify patients with unruptured ACoA aneurysm who were treated with endovascular embolization using the SMART coils. We aimed to report the angiographic outcome and peri-procedural complications of endovascular embolization of ACoA aneurysm according to the aneurysm size (&lt;4 mm vs. ≥4 mm). <h3>Results</h3> Out of 906 patients included in the SMART registry, 146 (16.1%) patients had unruptured ACoA aneurysms (age 60.8 ±11.9 yr and 61.6% were females). Of those ACoA, 43 were &lt;4 mm (micro-aneurysms). Microaneurysms were more likely to be wide-necked (84.6% vs. 54.2%, P 0.016). No difference was found in the rate of peri-procedural device related adverse effects, periprocedural mortality, rate of adequate occlusion immediately and at one-year, length of hospitalization and one-year recanalization rate between both groups (table 1). <h3>Conclusions</h3> Endovascular treatment of unruptured ACoA microaneurysms is associated with similar successful embolization and complication rates compared to larger size ACoA aneurysms. <h3>Disclosures</h3> <b>E. Almallouhi:</b> None. <b>M. Sattur:</b> None. <b>S. Al kasab:</b> None. <b>M. Anadani:</b> None. <b>A. Spiotta:</b> 2; C; Penumbra, Cerenovus, Minnetronix.
Early recipient chimerism testing in the T- and NK-cell lineages for risk assessment of graft rejection in pediatric patients undergoing allogeneic stem cell transplantation
Authors: S Breuer, S Preuner, G Fritsch, H Daxberger, M Koenig, U Poetschger, A Lawitschka, C Peters, G Mann, T Lion, S Matthes-Martin
Journal: Leukemia (2011)
Myocardial morphometric characteristics in swine.
Authors: S Singh, F C White, C M Bloor
Journal: Circulation Research (1981)

We have quantified the ultrastructure of myocardial cells in tissue samples obtained from six adult normal Yucatan swine. Tissue samples were obtained from 20 different sites in the left ventricle, right ventricle, and interventricular septum. The samples were processed for electron microscopy and quantitative morphometric analysis. The percent relative volumes of myofibrils, mitochondria, transverse tubular system, sarcoplasmic reticulum, and clear intracellular space were determined using stereological morphometric methods. Overall, the data were distributed homogeneously among the 20 individual sites. However, when certain subcellular components were examined regionally, some differences appeared. The mitochondrial:myofibril volume ratios were significantly increased in the left ventricle and interventricular septum compared to the right ventricle. They also were greater in the endocardial region compared to the epicardium, which is consistent with higher metabolic activity of these zones. Similarly, the sarcoplasmic reticulum:myofibril ratio was greater in the endocardial region vs. the epicardial region and the basal layer compared to the mid-layer, suggesting the greater need for provision of calcium ions in these particular zones. Since the swine is a convenient large animal for physiological studies, the results indicate that swine can also be used for quantitative morphometric measurements of myocardial changes in normal and pathologic hearts, and for the study of regional changes in various layers and regions of heart walls.