tbuckley/cabot-search huggingface dataset:
Dynamic postural stability in gaelic football players during a single leg drop-landing, a comparison of ankle tape and lace-up brace
Authors: U McCarthy Persson, C Arthurs
Journal: British Journal of Sports Medicine (2011)

Background Ankle inversion injuries commonly occur during landing from a jump. Both ankle braces and taping are methods used to prevent ankle injuries during sport. Objective To determine whether an ankle tape or ankle lace-up brace improves dynamic postural stability when compared without support on landing from a jump. The null hypothesis was that there would be no difference in Dynamic Postural Stability Index (DPSI) between the conditions. Design This was an experimental randomised intervention study. Setting University setting including club level Gaelic football players. Participants 15 subjects, all male (age=21.3 ± 1.6 years, height=182.2 ± 5.2 cm, mass=81.4 ± 8.2 kg, (mean ± SD)), without lower extremity injury or previous history of ankle injury. Interventions The subjects performed a jump protocol consisting of a single leg drop-landing from a 40 cm high step, under three randomised conditions: tape, ankle brace and control (neither tape nor brace). Main outcome measurements The Dynamic Postural Stability Index (DPSI) was analyzed after a single leg drop-landing on to a force plate. Results The application of an ankle tape increased the DPSI score (1365.04 ± 13.02) significantly when compared to the control (1354.9 ± 14.79), and brace (1359.6 ± 13.77) conditions (p&lt;0.02). This increase in DPSI indicates that the tape application decreased the dynamic stability on the force plate. There was no difference between the ankle brace and the control condition. Conclusion Application of an ankle tape decreased the ability to maintain dynamic balance during a jump landing in Gaelic football players without ankle injury. Further study needs to assess the effect of tape and brace application on athletes with ankle instability during jump landings. The possible causes of this decrease in stability will be discussed.
DIFFERENCES IN THE OCCURRENCE OF NEW OR WORSENING ANGINA BETWEEN THE ABSORB BIORESORBABLE VASCULAR SCAFFOLD AND XIENCE METALLIC STENT: A POST-HOC ANALYSIS OF THE ABSORB II RANDOMIZED TRIAL
Authors: Bernard Chevalier, Maik Grundeken, Roseann White, Yuki Ishibashi, Hector Garcia Garcia, Yoshinobu Onuma, Patrick Serruys
Journal: Journal of the American College of Cardiology (2015)
Regulation of human basophil adhesion to endothelium under flow conditions: Different very late antigen 4 regulation on umbilical cord blood-derived and peripheral blood basophils
Authors: Christopher L. Kepley, Ronald P. Andrews, David C. Brown, Alexandre Chigaev, Larry A. Sklar, Janet M. Oliver, Richard S. Larson
Journal: Journal of Allergy and Clinical Immunology (2002)
P2-171: Phase II and pharmacokinetic (PK) study of induction docetaxel/cisplatin followed by pulsed docetaxel chemoradiation for stage III non-small cell lung cancer
Authors: Yuhchyau Chen, Kishan J. Pandya, Therese Smudzin, Raman Qazi, Brian Smith, Joy Anderson, Ollivier Hyrien, Sandy Strychor, Brian Sidone, William C. Zamboni
Journal: Journal of Thoracic Oncology (2007)
Basophil response to peanut allergens in Mediterranean peanut‐allergic patients
Authors: C. Mayorga, F. Gomez, A. Aranda, S. J. Koppelman, A. Diaz‐Perales, N. Blanca‐López, A. B. Blazquez, M. Blanca, M. J. Torres
Journal: Allergy (2014)

Ara h 1, Ara h 2, and Ara h 3 are important sensitizers in peanut allergy. Ara h 9 has also been shown to be relevant in the Mediterranean area. We evaluated the basophil response to peanut allergens and Pru p 3 in Mediterranean patients: Group 1, peanut and peach allergy; Group 2, peanut allergy and tolerance to peach; Group 3, peach allergy and tolerance to peanut; Group 4, nonallergic subjects that tolerate both peanut and peach. Compared to controls (Group 4), there was an increased basophil activation with Ara h 2 (P = 0.031) and Pru p 3 (P = 0.009) in Group 1 and with Ara h 1 (P = 0.016), Ara h 2 (P = 0.001), and Ara h 9 (P = 0.016) in Group 2. Importantly, only Ara h 2 showed an increased activation (P = 0.009) in Group 2 compared to Group 3. Ara h 2 is the best discriminating allergen for peanut allergy diagnosis in a Mediterranean population showing two patterns: patients also allergic to peach, responding to Ara h 2 and Pru p 3, and patients allergic only to peanut, responding to Ara h 1, Ara h 2, and Ara h 9.
Doctors need not ventilate baby to prolong his life
Authors: Clare Dyer
Journal: BMJ (2004)

Doctors caring for a terminally ill baby with a chromosomal disorder need not provide mechanical ventilation to prolong his life, the senior family judge for England and Wales ruled last week.

The case of 9 month old Luke Winston-Jones is the second battle between parents and doctors over the treatment of a baby with a limited life expectancy to reach the High Court in the last month.

Both Luke's mother and the parents of 12 month old Charlotte Wyatt described their infants as “fighters” because both had lived longer than …
Particulate Air Pollution, Metabolic Syndrome, and Heart Rate Variability: The Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Sung Kyun Park, Amy H. Auchincloss, Marie S. O’Neill, Ronald Prineas, Juan C. Correa, Jerry Keeler, R. Graham Barr, Joel D. Kaufman, Ana V. Diez Roux
Journal: Environmental Health Perspectives (2010)

BackgroundCardiac autonomic dysfunction has been suggested as a possible biologic pathway for the association between fine particulate matter ≤ 2.5 μm in diameter (PM2.5) and cardiovascular disease (CVD). We examined the associations of PM2.5 with heart rate variability, a marker of autonomic function, and whether metabolic syndrome (MetS) modified these associations.MethodsWe used data from the Multi-Ethnic Study of Atherosclerosis to measure the standard deviation of normal-to-normal intervals (SDNN) and the root mean square of successive differences (rMSSD) of 5,465 participants 45–84 years old who were free of CVD at the baseline examination (2000–2002). Data from the U.S. regulatory monitor network were used to estimate ambient PM2.5 concentrations at the participants' residences. MetS was defined as having three or more of the following criteria: abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose.ResultsAfter controlling for confounders, we found that an interquartile range (IQR) increase in 2-day average PM2.5 (10.2 μg/m3) was associated with a 2.1% decrease in rMSSD [95% confidence interval (CI), −4.2 to 0.0] and nonsignificantly associated with a 1.8% decrease in SDNN (95% CI, −3.7 to 0.1). Associations were stronger among individuals with MetS than among those without MetS: an IQR elevation in 2-day PM2.5 was associated with a 6.2% decrease in rMSSD (95% CI, −9.4 to −2.9) among participants with MetS, whereas almost no change was found among participants without MetS (p-interaction = 0.005). Similar effect modification was observed in SDNN (p-interaction = 0.011).ConclusionThese findings suggest that autonomic dysfunction may be a mechanism through which PM exposure affects cardiovascular risk, especially among persons with MetS.
Towards Earlier Diagnosis in Primary Care
Authors: Mildred L. Geiger
Journal: JAMA (1980)

The expertise required to assess practically and accurately the office patient guarantees an eager approach to a book entitled<i>Towards Earlier Diagnosis in Primary Care</i>. The author, Keith Hodgkins, MD, has correctly diagnosed a medical training deficiency, namely, inadequate experience with office problems. The author has also correctly established the cause of the deficiency—"many common problems of general practice are never encountered in the hospital." The author's book, prescribed as therapy, consists of two phases. The first phase is an excellent overview of the primary physician's job of assessment and the patient's development, behavior, and responses to societal influences. The second phase of the therapy involves 400 pages of suspected or confirmed diagnoses of National Health Service patients in Britain, with compilation of symptoms and signs. Few of the ensuing suggestions for practice audit are applicable in this country and the "Clinical Pointers" are considered an inadequate part of Hodgkin's
A study of persistent light reaction in quindoxin and quinine photosensitivity
Authors: B.E. Johnson, S. Zaynoun, J.M. Gardiner, W. Frain-Bell
Journal: British Journal of Dermatology (1975)

Journal Article A study of persistent light reaction in quindoxin and quinine photosensitivity Get access B.E. Johnson, B.E. Johnson Department of Dermatology, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar S. Zaynoun, S. Zaynoun Department of Dermatology, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar J.M. Gardiner, J.M. Gardiner Department of Dermatology, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar W. Frain‐Bell W. Frain‐Bell Department of Dermatology, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 93, Issue s11, 1 July 1975, Pages 21–22, https://doi.org/10.1111/j.1365-2133.1975.tb06771.x Published: 01 July 1975
Long-term transvenous cardiac pacing with chardack-greatbatch (medtronic) pacemaker
Authors: W. Forbes, G. D. Green, G. B. Shaw, W. Bain
Journal: BMJ (1968)

Cardiac Pacemakers-SowtonEBLRn 13 (Johansson, 1966) while paced patients have a one-year mortal- ity of only 10-15% (Chardack, 1967;Sowton, 1967) it seems likely that the number of paced patients in Britain will continue to increase rapidly.It is to be hoped that improvements in pacemaker design and manufacture will continue, and will be matched by an increasing standard of implantation and follow- up care.Summary and Conclusions A retrospective survey of all cardiac pacemakers sold over a 12-month period in Britain was carried out and an 81 % return achieved.Of the pacing systems which failed the cause was not the generator itself in 43 % of cases.About one in every three patients stopped pacing before the pacemaker was replaced.Attempts should be made to improve follow-up procedures for paced patients.Thanks are due to the suppliers of the pacemakers concerned and to the many physicians, surgeons, and technicians who completed and returned the very full questionary.
STUDIES ON ANTIBODY PRODUCTION
Authors: Albert H. Coons, Elizabeth H. Leduc, Jeanne M. Connolly
Journal: The Journal of Experimental Medicine (1955)

A method for the specific histochemical demonstration of antibody in cells and parts of cells is described. It consists of carrying out a two stage immunological reaction on frozen sections of tissues: (a) allowing reaction between antibody in the tissue and dilute antigen applied in vitro, and (b) the detection of those areas where this antigen has been specifically absorbed by means of a precipitin reaction carried out with fluorescein-labelled antibody. Examination under the fluorescence microscope reveals the yellow-green fluorescence of fluorescein over those areas where a precipitate has formed. A study of the hyperimmune rabbit on the first few days after the last of a series of intravenous antigen injections reveals that antibody against human gamma-globulin or ovalbumin is present in groups of plasma cells in the red pulp of the spleen, the medullary areas of lymph nodes, the submucosa of the ileum, and the portal connective tissue of the liver. Because of extensive non-specific reactions, the bone marrow could not be examined. Small amounts of antibody were occasionally visible in cells in the lymphoid follicles of the spleen and lymph nodes, so that a minor contribution by lymphocytes to antibody synthesis cannot be excluded.
Serious eye injuries due to war games.
Authors: J. F. Acheson, M. F. Griffiths, R. J. Cooling
Journal: BMJ (1989)

Revue de 6 observations de lesions oculaires dues a ces «jeux» utilisant des projectiles de gelatine avec colorants, envoyes par des engins ressemblant beaucoup a des armes a feu. Les «joueurs» sont censes porter des lunettes protectrices et il est interdit de viser la tete
Book Review Clinical Nephrotoxins: Renal injury from drugs and chemicals Edited by M.E. De Broe, G.A. Porter, W.M. Bennett, and G.A. Verpooten. 481 pp., illustrated. Boston, Kluwer Academic, 1998. $265. 0-7923-3611-9
Authors: Mark S. Paller
Journal: New England Journal of Medicine (1998)
'A little learning': knowledge and health in the 18th century.
Authors: R Porter
Journal: Gut (1989)

Many high minded, improving physicians in 18th century England became convinced that the physician's vocation went beyond the merely clinical.It was the doctor's duty (they argued) not merely to attend individual patients but to address the ills of society at large.As Christopher Booth has shown so well, energetic figures such as John Fothergill, John
Register for occupational skin diseases.
Authors: M H Beck
Journal: BMJ (1991)

after causing neuropathy.9In contrast, patients with leprosy are not being warned about the dangers and sensory electrophysiological testing is not being done, precluding early detection and possible recovery after withdrawal of the drug.It is inexplicable why leprologists cannot carry out a simple clinical examination of the nervous system before administering thalidomide.It is a mistake to assume that nerve damage is already present in erythema nodosum leprosum: in 10 out of 14 patients whom I managed no signs of a polyneuropathy were present, according with the natural course of the disease.'Drug toxicity to the nervous system cannot be excluded now that it is admitted that neuropathy in lepromatous leprosy may mask the effects of thalidomide neuropathy and means also that thalidomide cannot now be claimed to prevent nerve damage.The ulnar mononeuritis sometimes accompanying erythema nodosum leprosum may fail to respond to thalido- mide.9High dose corticosteroids can be avoided in the management of erytheina nodosum leprosum, a condition that is not serious.As amyloidosis occurs in untreated lepromatous leprosy the lack of progression could also have occurred in treated patients without erythema nodosum and cannot be attributable to thalidomide.'°C
Side-effect of Antidepressant Drugs
Authors: G. G. Wallis
Journal: BMJ (1967)

drugs they prescribe would tend to vitiate the " rapport existing between the doctor and patient " ?Expecting trust or rapport to be possible in the face of such callous indifference to the safety of patients and others seems utterly incomprehensible.Equally dangerous is the habit of some doctors of not offering information on whether small or large amounts of alcohol can alter the effectiveness of any drug and its safety.-I am, etc., London S.W. 1.
The presence in experimental animals of a colon specific Mr 40,000 protein(s) with relevance to ulcerative colitis.
Authors: L Biancone, L S Wise, K M Das
Journal: Gut (1991)

In patients with ulcerative colitis a colon tissue bound IgG and serum antibodies against an Mr 40,000 colonic protein(s) has been identified. Using an anti-Mr 40,000 protein monoclonal antibody, 7E12H12, by an immunocytochemical method, the protein was localised in human tissue exclusively to colonic epithelial cells. In this study the presence of the Mr 40,000 protein was assessed in experimental animals by the direct and inhibition enzyme linked immunosorbent assays (ELISAs) using the anti-Mr 40,000 protein monoclonal antibody, 7E12H12 (IgM isotype). In addition, a total of 129 specimens including colon, small intestine, gall bladder, biliary tract, and kidney from nine strains of rats and mice, and from human tissue were studied by the immunocytochemical method using 7E12H12. All colon specimens from both humans and animals reacted with 7E12H12 in the immunocytochemical and ELISA assays. None of the non-colonic organs reacted with 7E12H12. While in human colon 7E12H12 recognised the absorptive epithelial cells, in all the animals it recognised mainly the colonic goblet cells. Extracts of animal colon but not of small intestine inhibited the binding of 7E12H12 to the human colon extract. This study shows the presence of an organ specific Mr 40,000 colonic epithelial protein(s) in humans and experimental animals. A differing cellular localisation of the Mr 40,000 protein(s) in human v animal tissue was also shown. Further characterisation of the Mr 40,000 protein(s) may provide important clues regarding the autoimmune mechanisms in ulcerative colitis.
791–6 Prospective Application of RAND Expert Panel Ratings, ACC/AHA Guidelines, and the University of Maryland Revascularizatlon Appropriateness Score (RAS): Only RAS Predicts Clinical Outcome
Authors: Andrew A. Ziskind, Michael A. Lauer, Cynthia C. Lemmon, Robert A. Vogel
Journal: Journal of the American College of Cardiology (1995)
The Length-Time Correlate in Appendicitis
Authors: Kenneth B. Deck
Journal: JAMA (1980)

A prospective study of 60 children with appendicitis suggested a correlation between the length of symptoms prior to perforation and the level of appendiceal obstruction. These observations support the concept that obstruction of the appendiceal lumen near its tip leads to early perforation, while obstruction near the base leads to late perforation. (<i>JAMA</i>244:806-807, 1980)
Lowering blood pressure in old people with multiple risk factors is worthwhile
Authors: David Spurgeon
Journal: BMJ (2001)

Doctors are often reluctant to treat hypertension in elderly patients with multiple risk factors for cardiovascular disease, yet these are the very patients who will gain most from such treatment, says a new report ( Circulation 2001;104:1923)..

The authors found that treatment in these patients was four times more effective in preventing heart attacks, strokes, and heart failure than in patients with lower levels of risk of cardiovascular disease.

They used an assessment tool developed by the American Heart Association to classify …
Screening for Impaired Hearing in the Elderly-Reply
Authors: Michael J. Lichtenstein
Journal: JAMA (1988)

<h3>In Reply. —</h3> We welcome the comments from Macphee et al regarding the use of free field voice testing for hearing impairment in the elderly. However, the studies they cite do not support their contention that free field voice testing is favorably comparable with the Welch-Allyn audioscope in screening for hearing impairment. There are two main methodological points that must be considered. First, the study sites and populations are substantially different. We tested the audioscope in the offices of primary care physicians, screening patients without regard for audiological symptoms. The study of free field voice testing by Swan and Browning<sup>1</sup>was conducted in an audiology clinic in a younger age group. Here subjects had been referred for audiological symptoms—under these circumstances, a "spectrum bias"<sup>2</sup>might inflate the sensitivity and specificity of the test. The study by Macphee et al<sup>3</sup>was conducted in a geriatric inpatient unit. Presumably
Change in prevalence of IgE sensitization and mean total IgE with age and cohort
Authors: Deborah Jarvis, Christina Luczynska, Susan Chinn, James Potts, Jordi Sunyer, Christer Janson, Cecilie Svanes, Nino Künzli, Bénédicte Leynaert, Joachim Heinrich, Marjan Kerkhof, Ursula Ackermann-Liebrich, Josep M. Antó, Isa Cerveri, Roberto de Marco, Thorarinn Gislason, Françoise Neukirch, Paul Vermeire, Matthias Wjst, Peter Burney
Journal: Journal of Allergy and Clinical Immunology (2005)
Successful Treatment With Plasmapheresis, Cyclophosphamide, and Cyclosporin A in Type B Syndrome of Insulin Resistance: Case report
Authors: Jan W Eriksson, Tomas Bremell, Björn Eliasson, Jesper Fowelin, Linda Fredriksson, Zhi-Wen Yu
Journal: Diabetes Care (1998)

CASE HISTORY A woman born in 1949 was diagnosed in 1990 with systemic lupus erythematosus. She was treated with prednisolone, and &amp;lt; 1 year later she presented with marked hyperglycemia. Large doses of insulin were given four times per day. Even though the patient was thin (BMI 17.4 kg/m2), very little improvement was seen. INVESTIGATIONS AND TREATMENT Serum insulin levels were high, and a euglycemic clamp investigation confirmed severe insulin resistance. The patient's serum contained insulin receptor antibodies inhibiting insulin binding, and thus the patient had a type B syndrome of insulin resistance. After diet and exercise, glycemic control stabilized and insulin treatment was withdrawn. However, in late 1993 she was in a catabolic and hyperglycemic state even though prednisolone doses were increased and azathioprin was added. In early 1994 she was treated with plasmapheresis and cyclophosphamide i.v. Subsequently, cyclosporin A was started as a maintenance therapy in addition to azathioprin. There was a rapid and sustained clinical improvement. Since late 1994 and onward, there is no sign of diabetes or glucose intolerance and there are no demonstrable insulin receptor antibodies in the patient's serum. DISCUSSION Severe type B insulin resistance may respond favorably to treatment with plasmapheresis and cyclophosphamide followed by cyclosporin A in combination with azathioprin.
Effect of Mandatory Parental Notification on Adolescent Girls' Use of Sexual Health Care Services
Authors: Diane M. Reddy
Journal: JAMA (2002)

ContextMandatory parental notification for adolescents to obtain prescribed contraceptives is a controversial issue. Recently, legislation that would prohibit prescribed contraceptives for adolescents without parental involvement was introduced in 10 states and the US Congress.ObjectiveTo determine the effect of mandatory parental notification for prescribed contraceptives on use of sexual health care services by adolescent girls.Design, Setting, and ParticipantsGirls younger than 18 years and seeking services at all 33 Planned Parenthood family planning clinics in Wisconsin (n = 1118) were surveyed during the spring of 1999. A response rate of 85% was achieved, yielding a sample of 950 girls.Main Outcome MeasuresPercentages of girls who reported that they would stop using all sexual health care services, delay testing or treatment for human immunodeficiency virus (HIV) or other sexually transmitted diseases (STDs), or discontinue using specific (but not all) services because of parental notification.ResultsFifty-nine percent (n = 556) indicated they would stop using all sexual health care services, delay testing or treatment for HIV or other STDs, or discontinue use of specific (but not all) sexual health care services if their parents were informed that they were seeking prescribed contraceptives. Eleven percent indicated they would discontinue or delay STD tests or treatment, even though the survey made it clear that mandatory parental notification would occur only for prescribed contraceptives. Analyses comparing girls of different ages and races and from urban vs rural clinics showed that, although the 17-year-olds and African American girls were significantly less likely to stop using sexual health care services with mandatory parental notification, roughly half of the 17-year-olds (56%) and African American girls (49%) indicated that they would stop using all sexual health care services, delay testing or treatment for HIV or other STDs, or discontinue use of specific (but not all) services with mandatory parental notification.ConclusionMandatory parental notification for prescribed contraceptives would impede girls' use of sexual health care services, potentially increasing teen pregnancies and the spread of STDs.
The transcription factor Srf regulates hematopoietic stem cell adhesion
Authors: Christine Ragu, Gaelle Elain, Elena Mylonas, Chris Ottolenghi, Nicolas Cagnard, Dominique Daegelen, Emmanuelle Passegué, William Vainchenker, Olivier A. Bernard, Virginie Penard-Lacronique
Journal: Blood (2010)