tbuckley/cabot-search huggingface dataset:
A Genome-Based Resource for Molecular Cardiovascular Medicine
Authors: David M. Hwang, Adam A. Dempsey, Ruo-Xiang Wang, Mojgan Rezvani, J. David Barrans, None MHSc, Ken-Shwo Dai, Hui-Yuan Wang, Hong Ma, Eva Cukerman, Yu-Qing Liu, Jian-Ren Gu, Jing-Hui Zhang, Stephen K. W. Tsui, Mary M. Y. Waye, Kwok-Pui Fung, Cheuk-Yu Lee, Choong-Chin Liew
Journal: Circulation (1997)

Large-scale partial sequencing of cDNA libraries to generate expressed sequence tags (ESTs) is an effective means of discovering novel genes and characterizing transcription patterns in different tissues. To catalogue the identities and expression levels of genes in the cardiovascular system, we initiated large-scale sequencing and analysis of human cardiac cDNA libraries.Using automated DNA sequencing, we generated 43,285 ESTs from human heart cDNA libraries. An additional 41,619 ESTs were retrieved from public databases, for a total of 84,904 ESTs representing more than 26 million nucleotides of raw cDNA sequence data from 13 independent cardiovascular system-based cDNA libraries. Of these, 55% matched to known genes in the Genbank/EMBL/DDBJ databases, 33% matched only to other ESTs, and 12% did not match to any known sequences (designated cardiovascular system-based ESTs, or CVbESTs). ESTs that matched to known genes were classified according to function, allowing for detection of differences in general transcription patterns between various tissues and developmental stages of the cardiovascular system. In silico Northern analysis of known gene matches identified widely expressed cardiovascular genes as well as genes putatively exhibiting greater tissue specificity or developmental stage specificity. More detailed analysis identified 48 genes potentially overexpressed in cardiac hypertrophy, at least 10 of which were previously documented as differentially expressed. Computer-based chromosomal localizations of 1048 cardiac ESTs were performed to further assist in the search for disease-related genes.These data represent the most extensive compilation of cardiovascular gene expression information to date. They further demonstrate the untapped potential of genome research for investigating questions related to cardiovascular biology and represent a first-generation genome-based resource for molecular cardiovascular medicine.
Oxyphenbutazone-lnduced Sialadenitis
Authors: Jaw H. Chen
Journal: JAMA (1977)

ACUTE swelling of the salivary glands can be caused by the administration of various kinds of drugs.<sup>1</sup>We report a case of oxyphenbutazone (Tandearil)-induced sialadenitis. <h3>Report of a Case</h3> A 52-year-old woman was admitted to Cabrini Health Care Center with acute onset of bilateral painful swelling of the salivary glands and fever. Five days prior to admission, she was given oxyphenbutazone, 100 mg three times a day, for superficial thrombophlebitis of the right leg. On the third day of therapy she started to experience profuse salivation and discomfort when she chewed food. On the fourth day she developed dryness of the mouth, a marked swelling of both parotid glands, and a temperature of 38.8 °C. On consulting her physician by telephone, she was instructed to stop taking the medication and was admitted to the hospital the following morning. The only other medications the patient had been taking were ampicillin
Helicobacter: New Name, New Hypothesis Involving Type of Gastric Cancer
Authors: Charles Marwick
Journal: JAMA (1990)

A COMMON bacterial infection, present in patients who have gastric and duodenal ulcers and gastritis, has been reported to be directly linked to one type of stomach cancer. The organism is<i>Helicobacter pylori.</i> Until a year ago this bacterium was known as<i>Campylobacter pylori</i>. The name was changed because it is sufficiently different from<i>Campylobacter</i>to warrant a genus of its own—<i>Helicobacter (Int J Systematic Bacteriol</i>. 1989;39:397-405). "Infections with Helicobacter are common, and most infected persons will have no symptoms," says Julie Personnet, MD, Stanford (Calif) University. "They are estimated to occur in half of American adults, although not all infected persons are necessarily at risk for gastric cancer. The infection is even more common in developing countries where it often occurs at a young age." <h3>Stanford Study</h3> "While other studies have demonstrated circumstantial evidence of an association between<i>Helicobacter</i>and gastric cancer, this is the first to show
The T348M mutated form of cryopyrin is associated with defective lipopolysaccharide-induced interleukin 10 production in CINCA syndrome
Authors: T Bihl
Journal: Annals of the Rheumatic Diseases (2005)

This case illustrates the usefulness of a therapeutic trial of colchicine monitored objectively by frequent acute phase protein measurements in patients with undiagnosed periodic fever syndromes.It also raises the possibility that a low threshold for analysing the FMF gene might disclose a wider spectrum of associated disease.
What Is Left
Authors: Vasae Burdick
Journal: Annals of Internal Medicine (2014)

Ad Libitum21 January 2014What Is LeftVasae BurdickVasae BurdickFrom Dallas, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M13-0337 Audio Reading - “What Is Left” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "What Is Left," by V. Burdick. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When did life's jagged edgespuncture the ripe plum of your heartand dribble out a song of sweetness?I sat next to her,tossing question after question,but no lasso brought the distant,shining sphere of her life closer.Grandma, I know you were a midwife and mother.When were moments delivered to you,hot, slick, precious as newborn babes,your yearning made tangible?I wanted her song before it was lost,but I took off the detective's trench coat,draped it over her knobby stand of knuckles.There, in the pocket of her fist, was my answer.like ... Author, Article, and Disclosure InformationAffiliations: From Dallas, Texas.Current Author Address: Vasae Burdick; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “What Is Left” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "What Is Left," by V. Burdick. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 21 January 2014Volume 160, Issue 2Page: 90KeywordsHeartMemory ePublished: 21 January 2014 Issue Published: 21 January 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A CAUSE OF FAILURE IN THE SURGICAL TREATMENT OF INTERNAL STRABISMUS.Read by title before the Pennsylvania State Medical Society, May. 1894.
Authors: HOWARD F. HANSELL
Journal: JAMA (1894)

indebtedness for some of the opinions I have here presented, to the distinguished oculist, Prof. Hirsch¬ berg, of Berlin, under whom I had the honor of pros¬ ecuting my studies while in Germany.One can not easily exaggerate the inspiration of his example.His superb technical abilities, including his patient carefulness, and, above all, his unwearied insistence, by precept and practice, of the observance of the requirements pertaining to antiseptic surgery, leave an impression upon those who come into contact with him not soon if ever obliterated.I dwell upon this latter, as too many are apt to belittle or disre¬ gard the preparatory precautions which so largely contribute to the success of an operation.Hirsch¬ berg is immovable in his adherence to even the smallest of these safeguards; which in one so emi¬ nent in his profession may well be considered strong evidence of the wisdom of their employment.
Mafenide Acetate in Burn Treatment
Authors: B. W. Haynes
Journal: New England Journal of Medicine (1971)

Elsewhere in this issue White and Asch present a detailed series of observations on the renal and pulmonary effects of carbonic anhydrase inhibition secondary to absorbed mafenide acetate (Sulfamylon) and its conversion product, paracarboxybenzine sulfonamide. Their data demonstrate that peak blood levels of the two agents occurred within two or three hours of application and were associated with increased renal excretion of bicarbonate, falling arterial bicarbonate levels compensated by hyperventilation resulting in a decreased arterial Pco2, and maintenance of normal blood pH. Similarly, inhibition of red-cell carbonic anhydrase resulted in a delay in carbon dioxide transfer across the . . .
Infectious Diseases in Obstetrics and Gynecology—IDOG
Authors: Irene M. Lathrop
Journal: JAMA (1994)

A recent survey of obstetrician-gynecologists on practices related to infectious diseases revealed substantial variation in practice patterns.<sup>1</sup>The authors found some clinical areas, such as management of perinatal viral infections, sexually transmitted diseases, and premature rupture of membranes, in need of further efforts for continuing medical education. In another survey, in the new journal under review, knowledge of basic microbiology and pharmacology and familiarity with current medical literature were deficient among residents and faculty.<sup>2</sup>This lack of standardization of knowledge in obstetric-gynecologic practice may be related to the scattering of the literature among a wide group of journals, some of it outside the specialty and not readily accessible to clinicians. To the rescue comes a new, peer-reviewed journal,<i>Infectious Diseases in Obstetrics and Gynecology</i>—<i>IDOG</i>, providing a single forum for the most current information on infectious diseases in the female. According to the editors,<i>IDOG</i>will disseminate
Molecular characterization of dog albumin as a cross-reactive allergen
Authors: Susanne Spitzauer, Christian Schweiger, Wolfgang R. Sperr, Budhi Pandjaitan, Peter Valent, Sonja Mühl, Christof Ebner, Otto Scheiner, Dietrich Kraft, Helmut Rumpold, Rudolf Valenta
Journal: Journal of Allergy and Clinical Immunology (1994)
Orthopaedics in Infancy and Childhood
Authors: Reginald R. Cooper
Journal: JAMA (1972)

This rather small treatise contains an amazing aggregate of information about diagnosis and treatment of children's musculoskeletal disorders. Lucid descriptions make reading not only easy but also enjoyable. The initial chapters describe disorders not limited to one part of the body. The remaining chapters each comment on regional orthopedic problems. The enlightening discussion of osteomyelitis, one of the few orthopedic emergencies in children, depicts signs and symptoms with clarity, accentuates the importance of early treatment, and rightfully emphasizes the need for surgical therapy, a point too often neglected, to the detriment of the patient in these days of antibiotics. Unfortunately the author fails to extend this vigorous support of surgical drainage to the treatment of pyogenic arthritis. Brief discussions of many epiphyseal and diaphyseal dysplasias, without photographs or roentgenograms, probably fail to clarify these confusing maladies, especially for a reader without prior acquaintance with the syndromes. The chapter on cysts
Characterization of proinsulin-insulin intermediates in human plasma.
Authors: C de Haën, S A Little, J M May, R H Williams
Journal: Journal of Clinical Investigation (1978)

This work addressed the problem of heterogeneity of immunoreactive insulin (IRI) in human plasma. Subjects with normal glucose tolerance were given 75g of an oral glucose solution, followed in 30 min by an intravenous infusion of 30g of arginine over 30 min. At the end of the infusion blood was withdrawn for analysis. IRI was extracted from plasma of individual subject by immunosorbent columns and was fractionated by gel filtration, disc gel electrophoresis and isoelectric focusing. Human IRI components were identified by molecular size, immunoreactivity with a human proinsulin antibody, sensitivity to trypsin, and by comparison of electrophoretic mobility and isoelectric point with porcine pancreatic products, after suitable correction for electric charge and molecular weight differences. The pattern of IRI heterogeneity was the same among six healthy subjects. Heterogeneity of proinsulin-size IRI in circulation was more marked than that of insulin-size material. Proinsulin and desdipeptide proinsulin were present in approximately equal amounts accompanied by minor amounts of split proinsulin and monodesamido-desdipeptide proinsulin. Insulin-size IRI contained over 80% insulin. Minor amounts of monodesamidoinsulin and diarginylinsulin were observed in some cases. The types of IRI components observed in plasma are evidence in support of a physiologic role of trypsin-and carboxypeptidase B-like enzymes in the conversion of proinsulin to insulin. Moreover, this study provides a base line for investigation of abnormalities in proinsulin-to-insulin conversion that may be associated with certain pathologic states.
A human neutrophil-dependent pathway for generation of angiotensin II. Purification of the product and identification as angiotensin II.
Authors: B U Wintroub, L B Klickstein, K W Watt
Journal: Journal of Clinical Investigation (1981)

A human neutrophil lysosomal protease interacts at physiologic pH with a 62,000--67,000-mol wt plasma protein substrate to generate a vasoactive, smooth muscle-contracting "neutral" peptide. The peptide product of this system, previously designated the "neutral" peptide-generating pathway, was generated from purified components and purified by Bio-Gel P2 gel filtration and reverse-phase high performance liquid chromatography with a 50--60% yield of starting activity. The purified peptide had an amino acid composition of Asx, Pro, Val, Ile, Tyr, Phe, His, Arg, a composition identical to that of angiotensin II. The peptide and synthetic angiotensin II each filtered at 48--52% bed volume on Bio-Gel P2, had an isoelectric point of Ph 7.8--8.1 at 4 degrees C, migrated 3 cm toward the cathode during pH 6.4 low-voltage paper electrophoresis, and had a retention time of 44.8 min during reverse-phase high-performance liquid chromatography. In addition, the functional activity of the peptide at each purification step correlated with angiotensin II content determined by specific radioimmunoassay. The amino acid sequence of 25 nmol of the peptide was Asp-Arg-Val-Try-Ile-His-Pro-Phe, the same covalent structure as that of angiotensin II. Therefore, under physiologic conditions, in the absence of renin or angiotensin converting enzyme, a human neutrophil neutral protease cleaves a plasma protein to yield angiotensin II. This pathway provides a mechanism through which the neutrophil may alter local blood flow during inflammation by generation of a potent vasoactive peptide.
ALBUMINURIA IN PREGNANCY
Authors: H. M. Raven
Journal: BMJ (1912)

MEDICAL JOUrNA 483 symptoms until the end of the tlhird month of pregnancy' and a hiistory of three months' ailenorrhoea is usually obtainable.On the other hand, witlh a lhaematocele the period of aimenorrhoea is very mlluclh less.The haeriorrlhage with retroverted gravid uteruis is irregular alnd cliscontiniuous.The clhief point of distinction is to be found by examination.Wlitlh retroversion of the uterus the cervix is tilted forwards and upwards, sometimes so mucl so that it is extremely difficult to reacll it with tlle finger, and the body of the uterrus cannot be felt in its normal position, whereas with lhaematocele, though the uterus mlay be verv much displaced forwards, the cervix will be directed downwards and the body can usually be distinguishedabove it.The soft consistence of the tumour and its definite out- linie are quite different fromii those of a haematocele.Inflammatory affections present the greatest difficulties, and in many cases the diagnosis is impossible.Pelvic cellulitis presents many points of similarity to laematocele, when the inflammatory mass forms beliind the uterus.It tends to encircle the rectum in the same way.It is accompanied by febrile disturbance and it
Blood Transfusion and Risk of Infection
Authors: Jeffrey L. Carson
Journal: JAMA (2014)

In this issue of JAMA, Rohde and colleagues report results of a meta-analysis evaluating the association between a liberal transfusion strategy vs a restrictive strategy and risk of hospital-acquired infections.1 In the meta-analysis, which included 17 randomized trials that compared these strategies among 7456 patients, the absolute rates of serious hospital-associated infection were 12.7% in the liberal transfusion group and 10.6% in the restrictive transfusion group. The number needed to treat with a restrictive transfusion strategy to prevent serious infection was about 48 patients. Results were consistent when analyses were repeated in trials with concealed randomization and infrequent protocol violations but not for overall infections. A prior meta-analysis of liberal vs restrictive transfusion strategies and infection outcomes reported a nonstatistically significant reduction in infections.2 The current meta-analyses by Rohde et al includes several newly published trials, although these significant differences in serious infection rates may not hold up when the results of other large transfusion trials are reported. Most trials define a restrictive transfusion strategy as the administration of red blood cells (RBCs) once hemoglobin falls below either 7 or 8 g/dL, and most trials define a liberal strategy as the administration of RBCs once hemoglobin level falls below 10 g/dL.
Children at High Altitude: Pulmonary and Renal Abnormalities
Authors: RICHARD L. NAEYE
Journal: Circulation Research (1965)

Changes in pulmonary arteries and renal glomeruli were assessed in children born and resident at high altitude (Leadville, Colorado). The hypoxia appears to arrest normal neonatal decrease of pulmonary arterial smooth muscle in some of these children. No abnormalities were found in pulmonary veins or capillaries. A quantitative study also demonstrated enlargement of renal glomeruli in the hypoxic children after the first month of life, apparently due to a proliferation of normal glomerular elements.
Role of the Oxygen Dissociation Curve in Hypoxia.
Authors: Claude Lenfant
Journal: Annals of Internal Medicine (1969)

s1 May 1969Role of the Oxygen Dissociation Curve in Hypoxia.Claude Lenfant, M.D., John Torrance, Ph.D.Claude Lenfant, M.D.Search for more papers by this author, John Torrance, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1108_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOxygen conductance from environment to tissues is regulated by such mechanisms as blood flow and hemoglobin concentration which have established importance. Another mechanism capable of ameliorating oxygen delivery to the tissues in case of hypoxia is a shift in the oxygen dissociation curve. It has been possible to show that this mechanism comes into action over a period of 1 to 2 days and that it appears to be regulated by the erythrocyte 2,3-diphosphoglycerate content that in turn appears responsive to venous oxygen saturation. Data were presented from normal subjects at altitude (natives and sojourners) and from patients with chronic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Claude Lenfant, M.D.; John Torrance, Ph.D.Affiliations: Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5 Page: 1108-1108 Keywords Attention Blood flow Hemoglobin Hypoxia Oxygen ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
STAT3 signaling is required for anti-OX40/TGF-β receptor blockade-mediated regression of large established tumors
Authors: Emmanuel T Akporiaye, Christopher Tucker, Todd Triplett, Kendra Garrison, Lihong Sun, Leona Ling, Andrew Weinberg
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts OX40 (CD134, TNFRSF4), a member of the tumor necrosis factor receptor (TNFR) superfamily is expressed on activated CD4+ and CD8+ T cells. In pre-clinical tumor models, agonist OX40 antibody (αOX40) therapy is often successful at treating small tumors but is less effective once
Henry Pelham (Boy With a Squirrel)
Authors: M. Therese Southgate
Journal: JAMA (2006)

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Audit suggests that use of aspirin is rising in coronary heart disease
Authors: R. King, J. Denne
Journal: BMJ (1995)

EDITOR,--The uptake of low dose aspirin in the secondary prevention of ischaemic heart disease has become a popular subject for audit in general practice. This was provoked by the publication of several reports and factsheets in early 1994, which showed the benefits and urged doctors to ensure that patients received the …
4&amp;ndash;Year Follow&amp;ndash;Up Results of a European Prospective Randomized Study on Neoadjuvant Hormonal Therapy prior to Radical Prostatectomy in T2&amp;ndash;3N0M0 Prostate Cancer
Authors: Claude C. Schulman, Frans M.J. Debruyne, Gerhard Forster, Francesco P. Selvaggi, Alexandre R. Zlotta, Wim P.J. Witjes
Journal: European Urology (2000)
Multimodal Imaging-Monitored Progression of Stroke-Like Episodes in a Case of MELAS Syndrome
Authors: Izzie Jacques Namer, Valérie Wolff, Jean-Louis Dietemann, Christian Marescaux
Journal: Clinical Nuclear Medicine (2013)

We report imaging findings during, between, and after 2 stroke-like episodes in a 45-year-old woman with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome with an A32243G mitochondrial mutation 6 years before. In November 2010, for a first episode, she showed mixed aphasia with logorrhea, disinhibition, agitation, euphoria, and a large left temporoparietal lesion. Symptomatology progressively regressed under L-arginine treatment. She was readmitted in June 2011 for a second episode with great anxiety, disorientation, impaired face recognition, worsening mixed aphasia, and a new right temporal lesion. After additional L-carnitine treatment, she remained without relapse for 14 months.