tbuckley/cabot-search huggingface dataset:
S118 Incidence And Severity Of Chronic Thromboembolic Pulmonary Hypertension Following The Introduction Of A One-stop Clinic For Acute Pulmonary Embolism
Authors: D. De Foneska, R. Condliffe, C. Elliot, R. Hughes, J. Hurdman, S. Ghafur, M. Schofield, J. van Veen, R. Maclean, D. Kiely
Journal: Thorax (2014)

<h3>Introduction</h3> The management and follow-up of pulmonary embolism (PE) is delivered by various specialities resulting in both under and over investigation for suspected chronic thromboembolic pulmonary hypertension (CTEPH). To standardise our approach to long-term PE management a “one-stop” clinic was established in Sheffield in March 2010 to review all patients approximately 3 months after their presentation with acute PE. The aim of this study was to evaluate the incidence and severity of CTEPH identified from a one-stop clinic using an investigative strategy based on careful clinical assessment <h3>Methods</h3> Consecutive patients attending the one-stop PE clinic following hospital admission with acute PE were identified. During the one-stop consultation a haematologist and respiratory physician reviewed the patient jointly. The need for further investigation was based on clinical assessment. CTEPH was defined as mean pulmonary artery pressure (mPAP) at right heart catheterisation ≥25 mmHg and required multimodality imaging (isotope perfusion scanning, CT pulmonary angiography and MR imaging including MRA and MR perfusion mapping) demonstrating classical features of CTEPH. <h3>Results</h3> Over a 3-year period between March 2010 and March 2013, 616 patients (mean age 67.7 years, 50% male) attended the one-stop PE clinic approximately 3 months following their acute presentation. 16 patients were diagnosed with CTEPH. An overall diagnostic rate of CTEPH of 2.6% for patients seen at the clinic and an annual incidence of 8.9/million/year was observed based on a referral population of 600,000. This compares to an annual incidence of CTEPH of 4.8/million/year in patients referred to the SPVDU over the same time period, based on a referral population of 15 million. The 16 patients with CTEPH had mPAP 37 ± 11 mmHg, pulmonary vascular resistance (PVR) 362 ± 240 dynes, significantly lower than patients with CTEPH diagnosed at the SPVDU until 2010 (n = 242) mPAP 48 ± 11 mmHg and PVR 735 ± 389 dynes (Hurdman <i>et al</i> Eur Respir J 2012:39(4):945–955). <h3>Conclusion</h3> Introduction of a one-stop PE clinic for routine follow-up of patients with acute pulmonary embolism identifies patients with higher rates of CTEPH with less severe pulmonary haemodynamic changes.
Induction of angiogenesis in a canine model of chronic myocardial ischemia with intravenous infusion of Vascular Endothelial Growth Factor (VEGF) combined with ultrasound energy and echo contrast agent
Authors: Zhongmin Zhou, Debabrata Mukherjee, Kai Wang, Xiarong Zhou, Khaldoun Tarakji, Keith Ellis, Albert W. Chan, Marc S. Penn, Jonny Ostensen, James D. Thomas, Mario Garcia, Eric J. Topol, Stephen G. Ellis
Journal: Journal of the American College of Cardiology (2002)
Treatment of Radiation Sickness
Authors: B. A. Stoll
Journal: BMJ (1967)

MEDICALJOURNALresults2 in apparently early patients, employ- ing systemic assessment and treatment in an admittedly small series, are sufficiently encouraging to warrant continuation.The arguments will continue anent a con- dition in which the deaths, using contem- porary measures, have increased by 4% from 1963 to 1964,3 but the long-repeated exercises in surgery and radiation which have hitherto shown little reward are still being pursued.The way ahead would seem to lie in improved systemic treatment for what is potentially a systemic condition even in the most appar- ently early patient.Minimal controlled surgery should only be permissible when a satisfactory systemic picture is present or obtained, and should certainly be delayed in the advanced patient.In the meantime, to catch the patient in apparent (with a negative systemic assess- ment) true Stage 1 should be our aim, since the results of treatment by any method are relatively good.We note that early detection at well-women clinics and self examination was not discussed at the symposium-the early detection of what is usually a symptomless condition is surely a prime necessity.-Weare, etc.,
Constipation is not associated with an increased rate of findings on colonoscopy: results from a national endoscopy consortium
Authors: M. Gupta, J. Holub, K. Knigge, G. Eisen
Journal: Endoscopy (2010)

There are no definite guidelines regarding colonoscopic evaluation for the indication of constipation, a common gastrointestinal complaint. The aim of our study was to determine the risk of finding significant lesions in patients undergoing colonoscopy for the indication of constipation alone compared with constipation with another indication or average-risk screening.A retrospective review of the Clinical Outcomes Research Initiative database was carried out for colonoscopies undertaken between 1 January 2000 and 30 June 2003. A total of 41,775 index colonoscopies performed for the indications of average-risk screening, constipation only or constipation with another indication were identified. Logistic regression analyses were performed for constipation alone versus constipation with another indication, and for constipation alone versus average-risk screening.Constipation alone did not show any increased risk of significant findings on colonoscopy. Constipation and the presence of another indication, however, had a statistically significant increased risk of a significant finding on colonoscopy. The indication of constipation alone had a lower risk of significant findings on colonoscopy compared with average-risk screening. Variations in the definition of constipation used was a limitation of the study.Colonoscopy for constipation alone has a lower yield for significant findings compared with average-risk screening and constipation with another indication; hence, colonoscopy should not be done for constipation alone.
251 A sirna targeted against srf reduces hepatocellular carcinoma cell proliferation, showing its potential use in the growth inhibition of this type of tumour
Authors: R. Farra, G. Pozzato, B. Dapas, E. Agostini, B. Scaggiante, G. Guarnieri, M. Colombo, G. Grassi
Journal: Journal of Hepatology (2006)
Patient-reported outcomes in pediatric patients with psoriasis undergoing etanercept treatment: 12-week results from a phase III randomized controlled trial
Authors: Richard G. Langley, Amy S. Paller, Adelaide A. Hebert, Kara Creamer, Haoling H. Weng, Angelika Jahreis, Denise Globe, Vaishali Patel, Seth J. Orlow
Journal: Journal of the American Academy of Dermatology (2010)
Abstract 3116: Is Bed Rest Recommendation In The Management Of Patients With Pulmonary Embolism And/or Deep Vein Thrombosis Evidenced-based Medicine: A Meta-analysis.
Authors: Christophe Meune, Nadia Aissaoui, Edith Martins-Meune, Stéphane Mouly, Simon Weber
Journal: Circulation (2007)

Background: Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) consists in an initial anticoagulation therapy with heparin followed by oral anticoagulants, that is associated with ...
Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling
Authors: F Buontempo, E Orsini, L R Martins, I Antunes, A Lonetti, F Chiarini, G Tabellini, C Evangelisti, C Evangelisti, F Melchionda, A Pession, A Bertaina, F Locatelli, J A McCubrey, A Cappellini, J T Barata, A M Martelli
Journal: Leukemia (2013)
APC Gene Testing for Familial Adenomatosis Polyposis
Authors: Hemant K. Roy, Janardan D. Khandekar
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Giving up on medicine: Good advice..
Authors: D. Bradford
Journal: BMJ (1993)

doing, it is relatively well paid (just compare your pay cheque with that of a non-clinical scientist).And what about when the children grow up?If she has the choice she should not give up the right to individuality, which is the right to be seen by society as a person in her own right and not simply as someone's mother or wife.I think that many of the writer's problems are philosophical in that she has realised her powerlessness in the face of disease and poverty.But she must not allow the fact that she is only one in six billion to depress her: it is the human condition.Nor should she sink into cynicism.There is a job to be done, and she can work to the good of society, in addition to earning a good salary.My message is: remember, women have struggled for centuries to have lives of their own and to be defined in terms of their own achieve- ments, not someone else's.Go and see your postgraduate dean, and anyone else you can think of, for some career advice.
Abstract 4661: Decreased epidermal growth factor receptor plasma levels as an indicator for head and neck squamous cell carcinoma case status and disease progression
Authors: Ann Marie Egloff, Lori Kelly, Monica Panelli, Autumn Gaither Davis, Jill M. Siegfried, Jennifer R. Grandis, Athanassios Argiris
Journal: Cancer Research (2010)

Abstract The epidermal growth factor receptor (EGFR), c-Met and G-protein-coupled receptor signaling pathways contribute to head and neck squamous cell carcinoma (HNSCC) growth. To assess these pathways in HNSCC patients, we measured plasma levels of EGFR, the EGFR ligands transforming growth factor alpha (TGF-α) and amphiregulin (AR), the c-Met ligand hepatocyte growth factor (HGF) and COX-2, a component of prostaglandin production, in HNSCC patients (n=22) and cancer-free controls (n=32) enrolled through an Early Detection Research Network- (EDRN-) sponsored effort. Analytes were measured using a multiplex enzyme-linked immunosorbent assay. Differences in analyte levels between cases and controls and the prognostic potential of each analyte were evaluated. EGFR plasma levels were significantly decreased (P=0.04, rank sum test (RST)) and HGF plasma levels significantly increased (P&amp;lt;0.01, RST) in HNSCC cases compared to cancer-free controls. TGF-α levels tended to be higher in HNSCC cases (P=0.07, RST) while AR and COX-2 levels did not differ between cases and controls (P=0.32 and 0.32, respectively RST). Area under the Receiver Operating Characteristic (ROC) curve for HGF levels in subjects with low EGFR plasma levels was 0.92. EGFR plasma levels were significantly reduced in HNSCC cases who were former or active smokers compared to never smokers (P = 0.009, Kruskal-Wallis test (KWT)), but no difference in EGFR plasma levels by smoking status was observed among cancer-free controls (P = 0.97, KWT). HGF plasma levels tended to be lower in HNSCC cases who were never smokers (P=0.06 KWT) but did not differ by smoking status among cancer-free controls (P=0.16, KWT). Low EGFR plasma levels were associated with significantly reduced progression-free survival (PFS) in EDRN HNSCC cases (P = 0.03, log rank test); no other analyte tested was associated with PFS. We noted a negative correlation between EGFR plasma levels in EDRN HNSCC cases and previously reported EGFR tumor levels assessed by immunohistochemical staining that was not significant (Spearman's rho=-0.41, P=0.10, n=17). Plasma EGFR and HGF levels may provide indications of HNSCC cancer status, and EGFR plasma levels may be a valuable prognostic indicator for patients with HNSCC. Decreased plasma EGFR levels in HNSCC patients were likely not due to general effects related to smoking and instead may reflect tissue characteristics specific to tobacco-related cancers. We found EGFR plasma levels in HNSCC patients were not positively correlated with EGFR tumor levels. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4661.
Transvaginal Cholecystectomy: Does a Go From Below Halt the Thunder Down Under?
Authors: Jennifer S. Gass
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Do appointment systems work?
Authors: D. Murphy
Journal: BMJ (1982)

impossible to make a distinction if an exan- thema due to /-lactam compounds is mediated by a "toxic" or an immunological mechanism.Therefore, once a rash occurs the best policy is to perform epicutaneous and intracutaneous tests for penicillin allergy, before subsequent administration of ampicillin or related drugs.In this way unexpected, unpleasant reactions may be avoided.
Re: Giacomo Novara, Antonio Galfano, Vincenzo Ficarra and Walter Artibani. Anticholinergic Drugs in Patients with Bladder Outlet Obstruction and Lower Urinary Tract Symptoms: A Systematic Review. Eur Urol 2006;50:675–83
Authors: Benedict T. Blake-James, Mark Emberton
Journal: European Urology (2006)
The Effect of Various Forms of Milk on Gastric-Acid Secretion
Authors: ANDREW F. IPPOLITI
Journal: Annals of Internal Medicine (1976)

Milk is commonly recommended as therapy for patients with peptic ulcer. The purpose of this study was to examine the effect of various forms of milk and 0.15 M NaCl (control) on gastric-acid secretion in five patients with duodenal ulcer during a period of remission and in five normal subjects. A significant (P < 0.05) increase in acid secretion in both groups was produced by 240 ml of whole, low-fat, and nonfat milk. The acid secretory responses to milk were equivalent to those produced by a 300-ml 10%-peptone meal and were approximately 20% to 35% of maximal betazole- or pentagastrin-stimulated acid output. Gastric-acid secretion did not increase after 0.15 M NaCl. Low-calcium milk produced a significant (P < 0.05) increase in acid secretion in the patients with duodenal ulcer but not in the normal subjects. Because milk contains both protein and calcium, and each are stimulants of gastric-acid secretion, there is reason to question its frequent ingestion by patients with peptic ulcer.
The Detection of Tubercle Bacilli by Fluorescence Microscopy
Authors: Leon Levinson, R. Leonard White
Journal: New England Journal of Medicine (1947)

THE method of fluorescent staining for the demonstration of tubercle bacilli in smears proposed in 1937 by Hagemann1 offered a promising simplification of the rather cumbersome Ziehl—Neelsen technic. Many in this country have tried the procedure and have not been impressed with the results.2 The objections are in some cases due to insufficient trial and in others to inadequate equipment. Better methods have now been developed, and it is the purpose of this paper to outline the technic and equipment and the results obtained therewith.The tubercle bacillus does not fluoresce of its own accord but can be made to . . .
The Diffusion of Influenza: Patterns and Paradigms
Authors: Stephen B. Thacker
Journal: JAMA (1987)

The purpose of this book is to demonstrate how geographic strategies can be used in the control and prevention of influenza. Dr Pyle reviews the familiar story of the global impact of influenza through the centuries, but with an eye toward understanding the spread of the virus in human populations. Because improved viral and epidemiologic data became available in the latter half of this century, the author can describe the geographic movement of influenza in increasing detail. Seven chapters of historical review, both of health issues and public policy, lead to the final chapter describing geographic models that might be applied to public health practice. For the most part, this book is written clearly, and the information is accessible to both epidemiologists and clinicians interested in influenza. General readers, however, will have difficulty with the final chapter on the simulation of influenza diffusion when Dr Pyle goes beyond simple regression
Individualization of Drug Therapy for the Parkinsonian Patient
Authors: Jose Beceiro
Journal: JAMA (1975)

<b>Dr. Lamar:</b>Our discussion today will focus on the need to individualize the total management of a parkinsonian patient to assure an optimal therapeutic benefit. This approach is especially important because of the well-recognized, remarkable variation in therapeutic response that exists among parkinsonian patients and even within the same patient from day to day. Perhaps 15% of parkinsonian patients do not achieve even a modicum of desired therapeutic response from one or more of the antiparkinsonian drugs they receive, while an equal proportion of patients derive intolerable drug side-effects—sometimes at low doses. Other patients may suffer from drug-drug interactions following coadministration of two or more antiparkinsonian drugs. The objective of this round is to discuss factors that must be considered to achieve optimal therapeutic results in the management of parkinsonism. The moderator of this conference will be Dr. Joseph R. Bianchine. <b>Dr. Bianchine:</b>Dr. Gordon, will you define Parkinson disease
Predicting Adherence to Colonoscopy or Flexible Sigmoidoscopy on the Basis of Physician Appointment–Keeping Behavior
Authors: Barbara J. Turner, Mark Weiner, Chuya Yang, Thomas TenHave
Journal: Annals of Internal Medicine (2004)

Background: Poor patient attendance to scheduled flexible sigmoidoscopy or colonoscopy may contribute to deficient colorectal cancer screening. Objective: To examine the association of physician appointment-keeping behavior with attendance to scheduled endoscopic studies of the colon. Design: Retrospective cohort. Setting: 23 sites performing endoscopic procedures in a health care system. Patients: 11 803 patients scheduled for a first colon study with 3 or more scheduled physician visits from June 1999 through November 2001. Measurement: 2 outcomes from health system computerized records: 1) attendance at the first scheduled colon study and 2) among nonattendees, attendance at the study rescheduled within 6 months. Physician visit adherence was defined as the proportion of physician visits kept, grouped by quartile. Adjusted associations were examined in conditional logistic regression. Results: Of 11 803 patients, 62% attended the first colon study. Of the 4496 nonattendees, 2739 (61%) rescheduled and, of these, 64% kept that appointment. Compared with the highest quartile of physician visit adherence (>85%), the adjusted odds ratio of attending the first colon study decreased as physician visit adherence decreased: Adjusted odds ratios were 0.94 (95% CI, 0.89 to 1.00) for 76% to 85% adherence, 0.87 (CI, 0.81 to 0.92) for 66% to 75% adherence, and 0.79 (CI, 0.73 to 0.85) for adherence of 65% or less. Among nonattendees who rescheduled, the lowest quartile of physician visit adherence (≤ 65%) was the only statistically significant predictor of attending the rescheduled study (adjusted odds ratio, 0.87 [CI, 0.78 to 0.98]). Limitations: The adherence measure applies only to patients with at least 3 scheduled visits. Persons having a colon study outside of the system could have been misclassified. Conclusion: Physician appointment-keeping behavior predicted attendance to colorectal endoscopic studies in this cohort and may help identify persons who need interventions to promote adherence.
Canada proposes tough antitobacco laws
Authors: D. Spurgeon
Journal: BMJ (1997)

The Canadian government has proposed strong new regulatory powers over the sale and advertising of tobacco. The move has prompted tobacco companies to appeal directly to the public through advertisements placed in the media.

Bill C-71 includes bans on vending machine sales; prohibits advertising through broadcasting, on billboards, street kiosks, and bus panels, and in point of sale displays; and regulates the …
CASE OF EXCISION OF CLAVICLE FOR A ROUND-CELLED SARCOMA
Authors: G. T. Beatson
Journal: BMJ (1902)

DURING the past two years I have had under my care a con- -siderable number of primary tumours of bone, the majority of which have been malignant and of the type known as sarcomata.Of the bones involved some were those usually attacked, such as the humerus, femur, and tibia, while there were others, such as the ulna, scapula, and clavicle, that are 'less commonly the seat of these new growths.
Gas-liquid chromatography in diagnosis of pyogenic arthritis.
Authors: M H Siefert, J A Mathews, I Philips, R A Gargan
Journal: BMJ (1978)

Gas-liquid chromatography in diagnosis of pyogenic arthritis Pyogenic arthritis must be diagnosed early if joint destruction is to be avoided.Differentiation from other arthropathies is crucial, and imme- diate aspiration and culture of synovial fluid is essential when infection is suspected.Synovial fluid contains pus cells in all inflammatory arthropathies and, since Gram-staining is of limited reliability, a further rapid screening test for infection would be of great help.The end products of in-vivo bacterial metabolism can be detected in clinical samples by gas-liquid chromatography (GLC).'This tech- nique has been applied to joint fluids in Reiter's disease and gonococcal arthritis.2The published methods are complex, entailing extraction and derivatisation of the metabolic products in the sample.We decided to evaluate a simplified, rapid technique, avoiding both extraction and derivatisation, for identifying volatile fatty acids in joint fluid.
The Piv-Otal Class II Transactivator Promoter Regulates Major Histocompatibility Complex Class II Expression in the Thymus
Authors: Karen Honey, Alexander Rudensky
Journal: The Journal of Experimental Medicine (2001)

Recognition of antigen by CD4+ T cells requires presentation of short peptide fragments in the context of heterodimeric MHC class II molecules ([1][1])([2][2]). Antigen presentation by MHC class II molecules is pivotal to the induction of adaptive immune responses, peripheral tolerance, and central