tbuckley/cabot-search huggingface dataset:
A NEW STAINING DISH
Authors: Roy R. Kracke
Journal: JAMA (1926)

For several years I have been impressed with the need for a method of staining sections of tissue and bacteriologic smears in large quantities. This need is felt particularly in large laboratories where tissue sections are stained for class work, where serial sections are prepared as in departments of histology, pathology and embryology in medical schools, in the laboratories of tuberculosis sanatoriums, and in the larger public health laboratories where staining is carried on extensively. Prompted by this need, I have designed the dish described here, believing that it will fulfil the need and demand for an article of this nature in that it modifies present staining methods to such an extent that rapid, efficient and economical staining can be carried out to a degree previously impossible with the older methods. <h3>APPARATUS</h3> The entire apparatus is constructed in three parts; the support, outside container, and slide rack. The
ADXS11-001 immunotherapy targeting HPV-E7: updated survival and safety data from a phase 2 study in Indian women with recurrent/refractory cervical cancer
Authors: Robert G Petit, Partha Basu
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts ADXS11-001 immunotherapy is a live attenuated Listeria monocytogenes ( Lm ) bioengineered to secrete a HPV-16-E7 fusion protein targeting HPV transformed cells. The Lm vector serves as its own adjuvant and infects antigen presenting cells (APC) where it cross presents, stimulating
Double somatostatinoma and double papillectomy in a patient with type 1 neurofibromatosis (von Recklinghausen's disease)
Authors: B. Oller, H. Haetta, V. Lorenzo-Zúñiga, J. Julián, V. de Vega, J. Fernández-Llamazares, J. Boix
Journal: Endoscopy (2012)

Neurofibromatosis type 1 (NF1) is a rare disorder that is associated with multiple benign and malignant neoplasms [1]. The most common gastrointestinal tumors occurring in patients with NF1 are neurofibromas, gastrointestinal stromal tumors of the small bowel, and ampullary carcinoid tumors or periampullary somatostatinomas. There is controversy about their endoscopic management.
Increased glutathione in chronic lymphocytic leukemia lymphocytes
Authors: Anna Maria Ferraris, Michela Rolfo, Rosa Mangerini, Gian Franco Gaetani
Journal: American Journal of Hematology (1994)

Abstract Following reports on a variety of interactions between glutathione (GSH) concentration and clinical parameters in solid tumors, a study was undertaken in order to determine the GSH intracellular content of chronic lymphocytic leukemia (CLL) lymphocytes. The results from a group of 16 patients consecutively studied indicate that B‐CLL cells have twice as much GSH as lymphocytes from normal subjects, suggesting that this measurement may be helpful in the understanding of the metabolic mechanism of the disease and the rationale of therapy. © 1994 Wiley‐Liss, Inc.
Does altered glucocorticoid homeostasis increase cardiovascular risk?
Authors: J GIROD, D BROTMAN
Journal: Cardiovascular Research (2004)

The hypothalamic–pituitary–adrenal (HPA) axis, like the sympathetic nervous system and the renin–angiotensin–aldosterone (RAA) system, sustains life in stressful situations by increasing vascular tone and ensuring fuel availability. It also modulates inflammation and tissue repair processes. Untoward cardiovascular effects of chronic sympathetic and RAA activation are well recognized, illustrating that the short-term benefit of the physiologic stress response can be detrimental in the long term. Similarly, chronic tissue exposure to glucocorticoids may lead to metabolic and vascular changes that accelerate vascular senescence. Specific situations associated with chronic activation of the HPA axis—such as major depression, inflammatory disease and perhaps the metabolic syndrome—may derive some of their associated cardiovascular risk from untoward glucocorticoid effects. Since there are no definitive clinical studies directly addressing the relationship between the HPA axis and cardiovascular disease, we present indirect evidence from two types of studies: (1) studies that examine the cardiovascular effects of exogenous glucocorticoids, and (2) studies demonstrating that endogenous glucocorticoid activity varies between individuals. The effects of physiologic increases in endogenous glucocorticoid activity may not always mirror the effects of supraphysiologic glucocorticoids. Nevertheless, the known effects of exogenous glucocorticoids provide important insights into the putative effects of endogenous glucocorticoids.
Dilatation and Pulsation of the Left Subclavian Artery in the Roentgen-Ray Diagnosis of Coarctation of the Aorta
Authors: HERBERT M. STAUFFER, LEO G. RIGLER
Journal: Circulation (1950)

Postero-anterior chest roentgenograms in 17 of 20 patients with coarctation of the aorta showed widening of the left upper mediastinal shadow attributed to dilatation of the left subclavian artery; pulsations of this vessel were evident in 12 of 13 cases with roentgenkymograms. In 3 of the latter cases rib notching was absent or equivocal. The subclavian pulsations may be observed fluoroscopically. Recognition of dilatation and pulsation of the left subclavian artery may provide roentgenologic corroboration of a diagnosis of coarctation of the aorta even in the absence of rib notching.
Reply to Marco Calcagno, Francesco Plotti, Maria Pastore and Pierluigi Benedetti Panici's Letter to the Editor re: Tomasz Rechberger, Konrad Futyma, Katarzyna Jankiewicz, et al. The Clinical Effectiveness of Retropubic (IVS-02) and Transobturator (IVS-04) Midurethral Slings: Randomized Trial. Eur Urol 2009;56:24-30
Authors: Tomasz Rechberger, Konrad Futyma, Katarzyna Jankiewicz, Aneta Adamiak, Paweł Skorupski
Journal: European Urology (2009)
Alpha<sub>1</sub>-Fetoprotein in Chronic Liver Disease
Authors: Hulbert K. B. Silver, Phil Gold, Joseph Shuster, Norman B. Javitt, Samuel O. Freedman, Niall D. C. Finlayson
Journal: New England Journal of Medicine (1974)

ALTHOUGH the production of detectable levels of alpha1-fetoprotein in adults has classically been associated with the development and growth of primary hepatomas, recent studies have demonstrated that it may be detected by radioimmunoassay in the serums of some patients suffering from nonmalignant hepatic disorders such as viral hepatitis1,2 and alcoholic cirrhosis.1,3 Several reports have indicated that some chronic hepatic disorders may terminate in the development of hepatoma,4,5 and that the hepatitis B antigen (HB Ag) may be an etiologic factor in the production of primary liver tumors in human beings.6 To examine the possible relations between these various factors, the . . .
The 100th birthday of appendicitis.
Authors: H Ellis
Journal: BMJ (1986)

3 GlaserJS. Newo-ophdaLmology. Maryland, United StatesofiAmerica: HarperandRow, 1978:300. 4 Duke-Elder. Text-book ofopkthabwolog. Vol 4. 1st ed. London: Henry Kimpton, 1949:3684. 5 Sacks OW. Migraine, sh ewvouton of a caoa dorder. Los Angeks: University of California Press, 1970. 6 Singer C. From magic to scene. London: Erneit Behn, 1928:230-4. 7 Airy H. On a disinct form ofrasient heiopa. Philos TransR SocLod 10;160:247-70. 8 Fothergill J. Remarks on that complint, commonly known under the nameofthe sick head-sh. Medical observi and iqries by a society ofphysicians in Lod. Vol 6. Ist ed. London: TCadell, 1784:103-37. 9 Fothergill J. Tky works ofjohn FodurgiU, MD. Vol 3. (Lettson JC, ed.) London: Charles Dilly, 1784:219-56. 10 Herschel JFW. Familiarlkcwaes on scieniAc subets. London: Alexander Stahan, 1866:406. 11 Hubel DH, Wiesel TN. Functiona architecture of macaque monkey visual cortex. Proc R Soc Load [BioL] 1977;198:1-59. 12 Brewster D. On hemiopsy, or half-vision. PhiWosophical Magazine 1865 29:503-7. 13 Wollaston WH. On semi-decuasation of the optic nerves. PAilos Trans R Soc Land 1824;114: 222-31. 14 LiveingE. On merim and sick hedache. London: Churchill, 1873. 15 Latham PW. On ervous or sickheadache, its vaes, and treament. Two lecses. Cambndge; Cambrige University Press, 1873. 16 Gowers W. Subjiecve visual sensaions. Trans Opkthahnol Soc UK 1895;1S:20-44. 17 GowersW.Subjeci snati ofsighsandsvud, abioeroMyandotiherlectres. London: Churchil, 1907:1841. 18 Parr CH. Eklem of patoog and theapeutics. Vol 1. 2nd ed. Bath: Richard Cruttwell, 1825:357. 19 Parry CH, ed. Coctions finm dt uublisbedmedical wrtings of she l Calb Hili Pory. London: Underwoodsa 1825:557. 20 Piorry PA. Du prcede opraie smvredans lexploretion dworgnaparaperewsion. Mediate, et, collectionsde mmoires surla physiogie, la pathologieesladiagnostic. Paris: Baillihre, 1831:409. 21 Airy GB. The astronomer royal on hemiopsy. PhilphicalMaaine 1865;30:19-21. 22 Duffy C. Fire and stone:fortress tarfare. Vancouver: Douglas David & Charles, 1975:9-18. 23 Smith EJ. The migraines. In: Osler W, Macrae T, eds. A syem of medicine. Vol 8. London: Hodder and Stoughton, 1910:750-68. 24 Mallet A. Lestravaxdemas. Vol M. Paris: Frederic Leonard, 1672:147. 25 Dickens C. The Pikcticppos. Ch 41. London: Chapimanand Hall, 1837.
Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?
Authors: Z H Yang, V Richard, L von Segesser, E Bauer, P Stulz, M Turina, T F Lüscher
Journal: Circulation (1990)

Endothelin-1 is an endothelium-derived vasoconstrictor peptide. Its circulating levels are below those known to evoke direct vascular effects. To study whether low concentrations of endothelin-1 potentiate the effects of other vasoconstrictor hormones, we suspended isolated human internal mammary and left anterior descending coronary artery rings in organ chambers for isometric tension recording. In mammary artery rings, the contractions to norepinephrine (3 x 10(-8) M) were potentiated by threshold (3 x 10(-10) M) and low concentrations (10(-9) M) of endothelin-1 (96 +/- 35% and 149 +/- 58% increase from control; p less than 0.01 and 0.001; n = 6). The inhibitor of endothelial nitric oxide formation L-NG-monomethyl arginine did not affect the potentiating effects of the peptide. The calcium antagonist darodipine (10(-7) M) prevented the potentiation of the response to norepinephrine evoked by endothelin-1. Similarly, contractions to serotonin (10(-7) or 3 x 10(-8) M) were amplified by endothelin-1 (3 x 10(-10) M) in the mammary (30 +/- 9%) and in the coronary arteries (59 +/- 25%). Endothelin-1 (10(-9) M) further potentiated the response (57 +/- 23% in mammary and 87 +/- 26% in coronary arteries; p less than 0.05; n = 7 and 3). The sensitivity of mammary arteries to calcium chloride was markedly enhanced in the presence of endothelin-1 (3 x 10(-10) M; concentration shift, eightfold; p less than 0.01; n = 5).(ABSTRACT TRUNCATED AT 250 WORDS)
A Preliminary Note on the Bacteriological Findings in Seven Cases of Enlarged Prostate
Authors: L. S. Dudgeon, C. Wallace
Journal: BMJ (1904)

BACTERIOLOGICALlFINDINGS IN ENLARGED PROSTATE.rDBo 31, Is904marked.The depressor substance can be removed from secretin solutions byV means of alcohol, as described by Bayliss and Starling; such preparations cause little or no fall of blood pressure, but give a good secretion of pancreatic juice, and an increased flow of lymph, as is shown in Experiment 4. Experiment 4. Dog anaesthetized with morphine and A.C.E.mixture.Cannulae in thoracic duct and pancreatic duct.Dog quiet throughout the experi- ment.Pancreatic Rmrs Timne.Lymph.Jieemarks.c.cm. c.cm. 3-40 to 3.50 10 -3.50ot04.009 4.0 tO 4.10 2.0 0.5 4.0 tO 4 8 injected so c.cm. secretin 4.0 to 4.20 2 3 J 7 free from depressor substance; 4.10 0 4 20 2.7 1-4 very slight fall in blood pressure.4-30 to 4.40 2.7 1.0
Cigar Smoking: Risky Business
Authors: Christine Kuehn Kelly
Journal: Annals of Internal Medicine (1998)

Currents15 July 1998Cigar Smoking: Risky BusinessChristine Kuehn KellyChristine Kuehn KellySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-2-199807150-00042 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Cigar smoking is neither safer than cigarettes nor a passing fad, according to “Cigars: Health Effects and Trends,” a new monograph published by the National Cancer Institute (NCI).“Physicians have an obligation to correct the impression for their patients that cigar smoking, including that of premium cigars, is safe,” said David M. Burns, MD, the monograph's senior scientific editor. “The toxic substances and carcinogens in cigar smoke, like those in cigarette smoke, are associated with increased risk of heart and lung disease.”Consumption of cigars in the United States began to increase in 1993 and almost doubled by 1997, when ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTeenage smoking in ChinaPrevention: Tobacco control and cancer nursing 15 July 1998Volume 129, Issue 2Page: 169KeywordsAdolescentsBurnsCarbon monoxideInhalationMucous membranesNicotineNicotine addictionPancreatic cancerParticulatesToxic agents Issue Published: 15 July 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Expression of AKR murine leukemia virus gp71-like and BALB(X) gp-71-like antigens in normal mouse tissues in the absence of overt virus expression.
Authors: P R McClintock, J N Ihle, D R Joseph
Journal: The Journal of Experimental Medicine (1977)

By competition radioimmune assays with antisera against AKR murine leukemia virus (MuLV) gp 71 or antisera against xenotropic virus, and iodinated AKR MuLV gp71 or BALB(X) gp71, antigens serologically indistinguishable from the viral antigens can be detected in tissues of normal mice in the absence of overt virus expression. An antigen serologically indistinguishable from AKR MuLV gp71 can be readily detected in normal bone marrow cells of the common strains of mice including NIH Swiss, 129/J, and SWR/J, as well as in Mus cervicolor and Mus musculus casteneus. In contrast, this antigen is not detected in normal spleen, thymus, lymph nodes, or serum. Similarly, an antigen serologically indistinguishable from BALB(X) gp71 was found in all normal mouse sera examined. This antigen was not present in fetal liver, perfused adult liver, thymus, spleen, lymph nodes, or bone marrow of the mice examined. An equivalent antigen was detected in sera from Mus musculus casteneus but not in sera from Mus cervicolor.
The baby business How money, science, and politics drive the commerce of conception
Authors: N. Green
Journal: Journal of Clinical Investigation (2006)

Throughout much of Western history, the uterus was considered an independent organism, a voracious animal within the female body that required “feeding”. That conceptualization rendered women mere bearers of children, despite very high risks of maternal and infant mortality. While complication rates have plummeted, having children is no longer viewed as satisfaction for the ravenous animal within. Yet as Debora Spar aptly describes in The baby business: how money, science and politics drive the commerce of conception, this hunger for children drives the booming business of reproductive technology. Approximately 15% of all couples in the United States admit to some degree of infertility. Thankfully, infertility is no longer considered a taboo-ridden measure of female or male inadequacy.
FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway
Authors: Matthew J. Potthoff, Jamie Boney-Montoya, Mihwa Choi, Tianteng He, Nishanth E. Sunny, Santhosh Satapati, Kelly Suino-Powell, H. Eric Xu, Robert D. Gerard, Brian N. Finck, Shawn C. Burgess, David J. Mangelsdorf, Steven A. Kliewer
Journal: Cell Metabolism (2011)
ASSOCIATION OF ATRIAL FIBRILLATION WITH CARDIAC EVENTS AND VENTRICULAR ARRHYTHMIAS IN PATIENTS IMPLANTED WITH CARDIAC RESYNCHRONIZATION. DATA FROM THE ACTION-HF STUDY
Authors: Gianluca Botto, Cosimo Damiano Dicandia, Massimo Mantica, Concetto La Rosa, Antonio D'Onofrio, Giulio Molon, Maria Grazia Bongiorni, Roberto Verlato, Eraldo Occhetta, Giovanni Q. Villani, Giovanni Raciti, Alberto Scaccia
Journal: Journal of the American College of Cardiology (2011)
Different Models in the Approach to the Doctor-Patient Relationship
Authors: R.A. Pierloot
Journal: Psychotherapy and Psychosomatics (1983)

In the last years the doctor-patient relationship has been the subject of many studies. However, the framework in which this relationship is approached is not always specified. The doctor-patient relationship is a specific form of interpersonal relationship. But this does not exclude that different models, formulated in the approach to interpersonal relationships in general, can also be applied to the doctor-patient relationship. In our exposition we reviewed four models in their application to the doctor-patient relationship: the communication model, the socio-cultural model, the model of medical transference and the model of human encounter. According to a given model, specific expectations of patient and doctor emerge and their interaction processes are formulated in specific concepts. The choice of a given model should be determined by the characteristics of a given medical situation and/or the objectives pursued.
Teaching the Resident in Internal Medicine
Authors: Stewart W. Shankel
Journal: JAMA (1986)

There appears to be a trend to move clinical teaching from bedside to conference room. While much emphasis is placed on conducting teaching rounds, no one asks how they are conducted. To evaluate how teaching is done, questionnaires on composition of teaching services and management of rounds including resident, patient care, attending, and teaching rounds were sent to 463 medicine residency programs. Responses were solicited from the program directors and chief residents. Two hundred twenty-one responded, but only for 123 programs did both the program director and the chief resident respond; these 123 programs formed the basis of our study. Fifteen percent of teaching rounds were held only in conference rooms, while 77% were made both at bedside and in conference rooms. The figures for attending rounds were 7% and 74%, respectively. Our data indicate a trend away from bedside teaching to the conference room.
Modelling the cost-effectiveness of first, second and third generation polychemotherapy regimens in women with early breast cancer who have differing prognoses.
Authors: H Campbell, D Epstein, S Griffin, M Sculpher, A Manca, D Bloomfield, J Yarnold, J Bliss, L Johnson, H Earl, C Poole, L Hiller, J Dunn, D Rea, P Hopwood, P Barrett-Lee, P Ellis
Journal: Cancer Research (2009)

Abstract Abstract #6106 Purpose: To use individual patient data from three sequential large UK randomised trials to facilitate an integrated comparison of the cost-effectiveness of three generations of chemotherapy plus a no treatment option. The ABC trial compared CMF versus no chemo (1991 patients), NEAT trial Epirubicin-CMF versus CMF (2391 patients) and TACT FEC-Docetaxel vs FEC or epi-CMF (4162 patients)&amp;#x2028; Methods: The model estimates lifetime costs and Quality-Adjusted Life Years (QALYs). Model inputs include transition probabilities which are estimated from a longitudinal observational study using parametric survival models incorporating characteristics such as number of positive lymph nodes, ER status, grade and tumour size that allow analyses to be conducted for women with differing baseline prognoses. The effects of each chemotherapy regimen on preventing recurrence are taken from the above UK trials and are assumed to be additive on the log scale to facilitate previously untested comparisons. Costs and utility decrements associated with chemotherapy, its toxicity, and type of recurrent disease, are informed from the trial data and published literature. A secondary analysis is performed by basing the effects of each chemotherapy regimen on published meta-analyses based on individual level data that include RCTs conducted in a range of multi-national settings.&amp;#x2028; Results: For a woman aged 50 years with 1 positive node, grade 2 tumour size 2cm, ECMF is expected to be the most cost-effective regimen. However, the cost-effectiveness of the chemotherapy options varies between women with different risk factors. On the basis of the results of the TACT trial, 3rd generation chemotherapy is not cost-effective, but including evidence of the relative risk of recurrence from non-UK trials, particularly those with ER- and HER2+ phenotype, may alter this conclusion.&amp;#x2028; Indicative lifetime costs and QALYs for a woman aged 50 years, with 1 positive node, grade 2 tumor size 2cm, with and without ER+ are shown:&amp;#x2028; &amp;#x2028; &amp;#x2028; &amp;#x2028; Conclusions: Evaluating the cost-effectiveness of chemotherapy regimens in women with early breast cancer who have differing prognoses is feasible using an integrative synthesis and model. Thought does, however, need to be given to how best present cost-effectiveness results when there are differing levels of baseline risk. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6106.
Heredofamilial Neuritis Of the Brachial Plexus
Authors: Arthur L. Poffenbarger
Journal: JAMA (1966)

<h3>To the Editor:—</h3> A form of neuritis of the brachial plexus of familial distribution was reported by Dreschfeld<sup>1</sup>in two sisters who suffered attacks of severe pain in shoulders and arms. These were followed by weakness and atrophy, but substantial eventual recovery. Ungley<sup>2</sup>observed a similar syndrome in a woman and her two daughters, in whom attacks were related to pregnancy and the puerperium. Taylor<sup>3</sup>described a five-generation family of 119 individuals, in which 22% of the female and 23% of the male members were affected. The neuritis was accompanied by excruciating pain, weakness, and sensory loss, followed by slow recovery; it resembled the serum neuritis in military personnel described by Parsonage and Turner.<sup>4</sup>A basic determinant was thought to be a genetically related sensitivity of nerve tissue to hyperergic reactions, with pregnancy and infections common precipitants. Jacob, Anderman, and Robb's<sup>5</sup>seven patients in two
Deciphering the role of APP in synaptic function
Authors: Hui Zheng
Journal: Molecular Neurodegeneration (2012)

Results We seek to understand the physiological functions of APP in neurons and synapses using in vivo mouse models and in vitro culture systems. Analysis of the APP knockout mice allows us to identify a functional role of APP in synaptic plasticity and learning and memory. Our investigation of mice deficient in APP and its homolog APLP2 establishes an essential role of APP family protein in mediating cholinergic synaptic structure and neurotransmission in both peripheral neuromuscular synapse and central cholinergic neurons. By creating an APP conditional allele, we demonstrate that APP is required in both pre- and postsynaptic terminals; and that pre- and postsynaptic APP interact to mediate synaptic structure and function. These in vivo findings are supported by in vitro mixed-culture studies, which reveal that APP potently induces synaptogenesis. Independent of the synaptic adhesion property that requires the full-length protein, we found that the soluble secreted APP ectodomain mediates transcription of genes related to aging and amyloid sequestration. Conclusion Our studies identify APP as synaptic adhesion and signaling molecules, which are mediated by distinct functional domains. Perturbation of these activities may contribute to synaptic dysfunction and AD pathogenesis.
Anionic polyethyleneglycol lipids added to cationic lipoplexes increase their plasmatic circulation time
Authors: Céline Nicolazzi, Nathalie Mignet, Natalia de la Figuera, Mamonjy Cadet, Raoul Torero Ibad, Johanne Seguin, Daniel Scherman, Michel Bessodes
Journal: Journal of Controlled Release (2003)