Subfulminant Liver Failure and Severe Hepatotoxicity Caused by Loratadine Use
Authors: Thomas D. Schiano
Journal: Annals of Internal Medicine (1996)

Brief Communications1 November 1996Subfulminant Liver Failure and Severe Hepatotoxicity Caused by Loratadine UseThomas D. Schiano, MD, Somashekhar V. Bellary, MD, Michael J. Cassidy, MD, Rebecca M. Thomas, MD, and Martin Black, MDThomas D. Schiano, MDFrom Temple University Hospital, Philadelphia, Pennsylvania., Somashekhar V. Bellary, MDFrom Temple University Hospital, Philadelphia, Pennsylvania., Michael J. Cassidy, MDFrom Temple University Hospital, Philadelphia, Pennsylvania., Rebecca M. Thomas, MDFrom Temple University Hospital, Philadelphia, Pennsylvania., and Martin Black, MDFrom Temple University Hospital, Philadelphia, Pennsylvania.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-9-199611010-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Loratadine is a long-acting tricyclic antihistamine with selective peripheral histamine-1-receptor antagonistic activity [1-3]. In a dosage of 10 mg/d, loratadine was found to be superior to placebo and similar in efficacy to other antihistamines for alleviating symptoms of allergic rhinitis [2, 3]. The increasing popularity of this drug results from its low propensity to cause drowsiness.Jaundice and hepatic necrosis associated with loratadine had previously been recognized in only one patient. This patient, who was also taking ketoconazole, subsequently received a liver transplant (Iezzoni DG. Personal communication). It was not clear whether loratadine was hepatotoxic in this patient. We describe ...References1. Clissold SP, Sorkin EM, Goa KL. Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1989; 37:42-57. Google Scholar2. Roman IJ, Danzig MR. Loratadine. A review of recent findings in pharmacology, pharmacokinetics, efficacy, and safety, with a look at its use in combination with pseudoephedrine. Clin Rev Allergy. 1993; 11:89-110. Google Scholar3. Loratadine—a new antihistamine. Med Lett Drugs. Ther. 1993; 35:71-2. Google Scholar4. Ulrich PP, Romeo JM, Lane PK, Kelly I, Daniel LI, Vyas GN. Detection, semiquantitation and genetic variation in hepatitis C virus sequences amplified from the plasma of blood donors with elevated aminotransferase. J Clin Invest. 1990; 86; 1609-14. Google Scholar5. Physicians' Desk Reference. 49th ed. Montvale, NJ: Medical Economics; 1995:2246-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Thomas D. Schiano, MD; Somashekhar V. Bellary, MD; Michael J. Cassidy, MD; Rebecca M. Thomas, MD; Martin Black, MDAffiliations: From Temple University Hospital, Philadelphia, Pennsylvania.Corresponding Author: Martin Black, MD, Gastroenterology Section, Temple University Hospital, 8th Floor, Parkinson Pavilion, 3401 North Broad Street, Philadelphia, PA 19140.Current Author Addresses: Dr. Schiano: Gastroenterology/Hepatology Division, University of Chicago Hospital, 5841 South Maryland Avenue, Chicago, IL 60637-1470. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPlasma exchange treats severe intrahepatic cholestasis caused by dacomitinib: A case reportSafety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic ReviewNo existen fármacos inocentes: daño hepatocelular inducido por desloratadinaDrugs and ToxinsLoratadineAntihistamine-Induced Hepatitis: 2 Cases Involving LoratidinePrediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donorsHepatic injury due to drugs, herbal compounds, chemicals and toxinsDrug‐Induced Liver DiseaseAzithromycin-induced liver injuryHepatotoxicidad por ebastinaLoratadineSecond-Generation AntihistaminesAcute cholestasis related to desloratidineToxicity of Drugs used for Treatment of Rhinitis: A Reminder to the OtorhinolaryngologistLoratadine 1 November 1996Volume 125, Issue 9Page: 738-740KeywordsAntibodiesBiopsyChronic liver diseaseDrugsLiverLiver diseasesLiver transplantationLoratadineNecrosisSerum glutamic oxaloacetic transaminase ePublished: 15 August 2000 Issue Published: 1 November 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...