tbuckley/cabot-search huggingface dataset:
Free Medical Care in China
Authors: Tsung O. Cheng
Journal: Annals of Internal Medicine (1976)

Comments1 September 1976Free Medical Care in ChinaTsung O. Cheng, M.D., F.A.C.P.Tsung O. Cheng, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-396 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: An article published in the January 1976 issue of the AMAs Prism by James H. Sammons, M.D., and Joe D. Miller entitled "China Report (Part II): The Myth of Free Medical Care" contained many misleading statements about which I have received many inquiries. Instead of answering individually, I write this letter to disseminate important and corrective information because Prism has not been published since the January issue. To leave Sammons and Miller's misrepresentative article unchallenged will not only give credence to some of the irresponsible statements made in the article, but will also not be in the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1976Volume 85, Issue 3Page: 396-397 ePublished: 1 December 2008 Issue Published: 1 September 1976 PDF downloadLoading ...
Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response
Authors: Margareth C. Ozelo, Barbara Vidal, Christine Brown, Colleen Notley, Carol Hegadorn, Sandra Webster, Lori Harpell, James Ahlin, Andrew Winterborn, Janine Handforth, Valder R. Arruda, Christine Hough, David Lillicrap
Journal: Blood (2014)
Red Blood Cell Survival in Patients with Aortic Valvular Disease and Ball-Valve Prostheses
Authors: MICHAEL T. BRODEUR, DONALD W. SUTHERLAND, ROBERT D. KOLER, ALBERT STARR, JEAN A. KIMSEY, HERBERT E. GRISWOLD
Journal: Circulation (1965)

Red blood cell survival was determined in patients with aortic valvular disease, postoperative patients with aortic valvular ball-valve prostheses and postoperative patients with multiple ball-valve prostheses. The red blood cell survival was reduced in the majority of patients in each group when compared with the red blood cell survival from a normal control group. A detailed analysis of the survival curves suggested that in many patients there was more than one population of red blood cells. The first population displayed rapid random destruction. This population was not present in normal persons in the control group. The second population showed the usual decline in radioactivity due to random destruction and loss of the red cell label due to elution. The shortened red blood cell survival in some patients was due to a large percentage of the first population of randomly destroyed red blood cells, in other patients to an accelerated rate of destruction of the usual single population of cells while others had a combination of the two mechanisms. A mechanism of mechanical hemolysis due to increased intracardiac turbulence was suggested as a cause for the shortened survival. When the turbulence was increased by a leak around the aortic or mitral valve prosthesis the red blood cell survival was found to be further decreased. In some cases this reduction in survival was enough to produce hemolytic anemia. The Coombs antiglobulin test was positive in three patients. The suggestion was made that the development of autoantibodies to red blood cells was secondary to increased destruction of red blood cells.
Plan aims to end discrimination in mental health services
Authors: Zosia Kmietowicz
Journal: BMJ (2005)

The way black and other ethnic minority people with mental health problems are treated by health and social care services in England is to be scrutinised under new reforms aimed at ending discrimination in mental health services.

The action plan, entitled Delivering Race Equality in Mental Health Care , was launched this week by the health minister Rosie Winterton. It is part of the government's response to the independent inquiry …
Cholesterol enrichment increases basal and agonist-stimulated calcium influx in rat vascular smooth muscle cells.
Authors: R A Bialecki, T N Tulenko, W S Colucci
Journal: Journal of Clinical Investigation (1991)

The effect of cholesterol enrichment on vascular smooth muscle cell (VSMC) calcium homeostasis was studied by evaluating calcium uptake, efflux, and intracellular content in cultured VSMC derived from the rat pulmonary artery. Incubation of VSMC with liposomes consisting of free cholesterol (FC) and phospholipid (2:1 molar ratio, 1 mg FC/ml medium) for 24 h resulted in a 69 +/- 19% increase (P less than 0.01; n = 10) in FC which was associated with a 73 +/- 11% increase (P less than 0.005; n = 10) in intracellular calcium content as assessed by isotopic equilibrium with 45Ca2+ and a 65 +/- 11% increase (P less than 0.024; n = 3) as assessed by atomic absorption spectroscopy. Cholesterol enrichment caused a marked increase in the unidirectional calcium uptake rate from 0.026 +/- 0.03 to 0.158 +/- 0.022 nmol calcium/s per mg protein (P less than 0.01; n = 3), but had no effect on calcium efflux. Nifedipine (1 microM) reduced (P less than 0.05; n = 6) the effect of cholesterol enrichment on unidirectional calcium uptake by 78 +/- 16%; and verapamil (10 microM), diltiazem (1 microM), and nifedipine (1 microM) each significantly inhibited the effect of cholesterol enrichment on intracellular calcium accumulation. Exposure of cholesterol-enriched VSMC to cholesterol-poor liposomes for 24 h returned both FC and calcium contents to control levels. Serum- and serotonin-stimulated calcium uptakes were potentiated 3.7- and 1.7-fold, respectively, in cholesterol-enriched VSMC, whereas endothelin, vasopressin, and thrombin-stimulated calcium uptakes were not affected. We conclude that VSMC FC content plays a role in regulating cellular calcium homeostasis, both under basal conditions and in response to selected agonists.
Lysyl Oxidase Plays a Critical Role in Endothelial Cell Stimulation to Drive Tumor Angiogenesis
Authors: Ann-Marie Baker, Demelza Bird, Jonathan C. Welti, Morgane Gourlaouen, Georgina Lang, Graeme I. Murray, Andrew R. Reynolds, Thomas R. Cox, Janine T. Erler
Journal: Cancer Research (2012)

Abstract Identification of key molecules that drive angiogenesis is critical for the development of new modalities for the prevention of solid tumor progression. Using multiple models of colorectal cancer, we show that activity of the extracellular matrix–modifying enzyme lysyl oxidase (LOX) is essential for stimulating endothelial cells in vitro and angiogenesis in vivo. We show that LOX activates Akt through platelet-derived growth factor receptor β (PDGFRβ) stimulation, resulting in increased VEGF expression. LOX-driven angiogenesis can be abrogated through targeting LOX directly or using inhibitors of PDGFRβ, Akt, and VEGF signaling. Furthermore, we show that LOX is clinically correlated with VEGF expression and blood vessel formation in 515 colorectal cancer patient samples. Finally, we validate our findings in a breast cancer model, showing the universality of these observations. Taken together, our findings have broad clinical and therapeutic implications for a wide variety of solid tumor types. Cancer Res; 73(2); 583–94. ©2012 AACR.
Endogenous myocardial protective (antiarrhythmic) substances
Authors: J. Parratt
Journal: Cardiovascular Research (1993)

Journal Article Endogenous myocardial protective (antiarrhythmic) substances Get access Jim Parratt Jim Parratt Cardiovascular Research, Department of Physiology and Pharmacology, University of Strathclyde, Royal College, 204 George Street, Glasgow G1 1XW, United Kingdom: Professor J R Parratt. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 5, May 1993, Pages 693–702, https://doi.org/10.1093/cvr/27.5.693 Published: 01 May 1993 Article history Accepted: 13 October 1992 Published: 01 May 1993
ABC of antenatal care, Vaginal bleeding in early pregnancy--I.
Authors: G Chamberlain
Journal: BMJ (1991)

Bleeding drives patients to their general practitioner swiftly.Vaginal bleeding in pregnancy makes the woman think that she may be miscarrying, so this brings her even more promptly; the practitioner thence has the Causes of bleeding opportunity to diagnose the cause and start prompt management.* Abortion or miscarriage Bleeding has four known causes in early pregnancy (box).In addition, * Ectopic pregnancy bleeding occurs for no apparent reason in a large number of cases.In early * Trophoblast disease pregnancy such cases are commonly categorised as threatened miscarriage, * Lesions of cervix or vagina but this is fudging the issue for in many cases the conceptus and its future placental system are not involved; doctors should be honest and say that they do not know the cause. Miscarriage or abortionThe terms miscarriage and abortion are almost synonymous, but miscarriage is a softer word used for the spontaneous event.Threatened miscamrage-Women bleed a little from the vagina during a threatened miscarriage but there is little abdominal pain.The uterus is Types of miscarriage enlarged and the cervix closed.Pregnancy may proceed.Incomplete miscamage-Abortion is inevitable and the cervical os open in * Threatened miscarriage an incomplete miscarriage.Blood loss is often great and lower abdominal * Inevitable miscarriage cramping pains accompany the uterine contractions.Some products of Complete conception and clots may be passed but much decidua is retained and so the Incomplete abortion is incomplete.* Missed abortion Complete miscarriage-The cervical os is open and the uterus completely* Recurrent miscarriage expels its contents in a complete miscarriage.Such miscarriages are more * Criminal abortion likely after 16 weeks of pregnancy than earlier, when they are mostly * Septic abortion incomplete.* Therapeutic abortion * Respiratory system Monitor-Blood gases Treatment-Oxygen ?Ventilate
Ventricular adenine nucleotide translocator mRNA is upregulated in dilated cardiomyopathy
Authors: C. Sylven, L. Lin, E. Jansson, P. Sotonyi, L.-X. Fu, F. Waagstein, A. Hjalmarsson, C. Marcus, M. Bronnegard
Journal: Cardiovascular Research (1993)

Objective: A disturbed energy transfer involving the adenine nucleotide translocator across the inner mitochondrial membrane has been suggested to be one specific pathogenetic mechanism in dilated cardiomyopathy. Pretranslational steady state expression of this protein in dilated cardiomyopathy was investigated. Methods: Concentrations of adenine nucleotide translocator were quantified by solution hybridisation. The enzyme or protein expressions of citrate synthase, lactate dehydrogenase, and creatine kinase with isozymes were determined. Analysis was performed on specimens from the left and right ventricles from six organ donor hearts, six explanted hearts with dilated cardiomyopathy, two explanted hearts with ischaemic cardiomyopathy, and from papillary muscles from seven patients operated on for mitral regurgitation. Results: The ejection fraction in patients with mitral regurgitation was 50(10)%, significantly higher (p<0.001) than in patients with dilated cardiomyopathy (23(5))%. In mitral regurgitation and in ischaemic cardiomyopathy left ventricular adenine nucleotide translocator mRNA concentrations did not differ from those in donor hearts. In dilated cardiomyopathy, adenine nucleotide translocator mRNA concentrations were significantly increased (p<0.001). Upregulation was more pronounced in right ventricular than in left ventricular myocardium (p<0.01). The lactate dehydrogenase M subunit fraction was increased to a similar degree in dilated cardiomyopathy and in mitral regurgitation (p<0.05). Citrate synthase activity was significantly decreased only in dilated cardiomyopathy (p<0.005). On the other hand, the creatine kinase B subunit content was significantly higher in mitral regurgitation than in dilated cardiomyopathy (p<0.001). Conclusions: Despite signs of increased anaerobic and depressed oxidative capacities, dilated cardiomyopathy was specifically characterised by pretranslational upregulation of adenine nucleotide translocator. Cardiovascular Research 1993;27:1295-1299
The naked truth
Authors: S. Bewley, R. Fawdry, G. Cummings, H. Perry
Journal: BMJ (2010)

Despite the expense, frustration, and slow implementation of electronic health records, hospital clinicians still believe in “imagined, ideal electronic records systems.”1 But is this a case of an emperor with no clothes? There is little hard evidence of benefits in patient outcome, and confidentiality concerns remain.2 The rigidity of analysable electronic records has been underestimated. Terminology and …
Smoking Cessation in Relation to Total Mortality Rates in Women: A Prospective Cohort Study
Authors: Ichiro Kawachi
Journal: Annals of Internal Medicine (1993)

Objective: To examine the temporal relationship between stopping smoking and total mortality rates among middle-aged women. Design: Prospective cohort study with 12 years of follow-up. Setting: Registered nurses residing in the United States. Participants: 117 001 female registered nurses, ages 30 to 55 years, who were free of manifest coronary heart disease, stroke, and cancer (except nonmelanoma skin cancer) in 1976. Main Outcome Measures: Total mortality, further categorized into deaths from cardiovascular diseases, cancers, and violent deaths. Results: A total of 2847 deaths (933 among never smokers, 799 among former smokers, and 1115 among current smokers) occurred during 1.37 million person-years of follow-up. The multivariate relative risks for total mortality compared with never smokers were 1.87 (95% CI, 1.65 to 2.13) for current smokers and 1.29 (CI, 1.14 to 1.46) former smokers. Participants who started smoking before the age of 15 years had the highest risks for total mortality (multivariate relative risk, 3.15; CI, 2.16 to 4.59), cardiovascular disease mortality (relative risk, 9.94; CI, 5.15 to 19.19), and deaths from external causes of injury (relative risk, 5.39; CI, 1.84 to 15.78). Compared with continuing smokers, former smokers had a 24% reduction in risk for cardiovascular disease mortality within 2 years of quitting. The excess risks for total mortality and both cardiovascular disease and total cancer mortality among former smokers approached the level of that for never smokers after 10 to 14 years of abstinence. The health benefits of cessation were clearly present regardless of the age at starting and daily number of cigarettes smoked. Conclusions: The risk of cigarette smoking on total mortality among former smokers decreases nearly to that of never smokers 10 to 14 years after cessation.
Comparison of parasite sequestration in uncomplicated and severe childhood Plasmodium falciparum malaria
Authors: Aubrey J. Cunnington, Michael T. Bretscher, Sarah I. Nogaro, Eleanor M. Riley, Michael Walther
Journal: Journal of Infection (2013)

ObjectivesTo determine whether sequestration of parasitized red blood cells differs between children with uncomplicated and severe Plasmodium falciparum malaria.MethodsWe quantified circulating-, total- and sequestered-parasite biomass, using a mathematical model based on plasma concentration of P. falciparum histidine rich protein 2, in Gambian children with severe (n = 127) and uncomplicated (n = 169) malaria.ResultsCirculating- and total-, but not sequestered-, parasite biomass estimates were significantly greater in children with severe malaria than in those with uncomplicated malaria. Sequestered biomass estimates in children with hyperlactataemia or prostration were similar to those in uncomplicated malaria, whereas sequestered biomass was higher in patients with severe anaemia, and showed a trend to higher values in cerebral malaria and fatal cases. Blood lactate concentration correlated with circulating- and total-, but not sequestered parasite biomass. These findings were robust after controlling for age, prior antimalarial treatment and clonality of infection, and over a realistic range of variation in model parameters.ConclusionExtensive sequestration is not a uniform requirement for severe paediatric malaria. The pathophysiology of hyperlactataemia and prostration appears to be unrelated to sequestered parasite biomass. Different mechanisms may underlie different severe malaria syndromes, and different therapeutic strategies may be required to improve survival.
Clinical and echocardiographic features of pulmonary valve endocarditis.
Authors: K Nakamura, G Satomi, T Sakai, M Ando, A Hashimoto, H Koyanagi, K Hirosawa, A Takao
Journal: Circulation (1983)

We studied the clinical and echocardiographic features of eight patients with infective pulmonary valve endocarditis. In two patients, the vegetation was limited to the pulmonary valve; in the six other patients, infective lesions were also present on the mitral or aortic valves. None of the patients were addicted to narcotics. Seven of the eight patients had underlying congenital heart disease. In six patients the organism responsible for the infective endocarditis was Streptococcus viridans. Two-dimensional echocardiography performed using a wide-angle sector scanner was more useful than M-mode echocardiography for evaluating patients with pulmonary valve endocarditis.
The Rate of Death due to Injuries-Reply
Authors: Victoria W. Persky
Journal: JAMA (1991)

<h3>In Reply.—</h3> Dr Doege's letter appropriately focuses on the impact of injuries as an important portion of the total mortality in the United States. He also points out that for age-adjusted mortality rates it is the third leading cause of deaths with a rate of 35.5 per 100 000, ahead of cerebrovascular disease with a rate of 30.4 per 100 000. As Dr Doege states, the decline in age-adjusted injury rates has been impressive and reflects major advances in prevention of both motor vehicle and non-motor vehicle accidents. Trends in age-adjusted death rates control for changes in the age composition of the population. The proportionate mortality rates published in our article have been calculated from the crude death rate. They are a more accurate reflection of the total burden of disease on society. In 1986, the total deaths of 2 105 361 included 159 643 deaths due to cerebrovascular disease
PHYSICAL THERAPY ABROAD
Authors: Disraeli Kobak
Journal: JAMA (1925)

<h3>To the Editor:</h3> —Many American physicians are still in doubt as to the value of physiotherapy; on the other hand, a growing group of physicians have permitted their enthusiasm to get the better of their more sober judgment. Various electrical agents are in evidence in most of the important clinics of Europe. Galvanization is practiced both as a diagnostic and as a therapeutic agent. Hydrotherapy and heliotherapy are much in vogue at the various spas. Diathermy and ultraviolet therapy enjoy popularity both on the continent and in England, owing to the good results obtained by these agents during the war and the period of reconstruction. Ultraviolet, especially, is accepted with a greater degree of enthusiasm, owing, no doubt, to the splendid researches of such men as Hausser of Berlin, Davos of Dorno, and Hausmann of Vienna. In England, the University of Cambridge offers a six months' course with a diploma
School-Taught English And Bodily Functions
Authors: Heinrich Lamm
Journal: JAMA (1973)

<h3>To the Editor.—</h3> When I started practice in Texas near the Mexican border in the late thirties, I had to learn Spanish, because many people spoke only Spanish. Since those days thousands of Mexican children have gone through public schools here, have been exposed to radio (much in English) and later to television (most in English), and have learned to live in an essentially English-speaking society and by and large have learned English well. Many now speak English rather than Spanish within their families. Probably Spanish will remain a living language in the United States along the Mexican border, yet for most people below forty English is their main and natural language, be the surname Hérancourt, Hudson, Heliopolidou, Herrera, or Hugendubel. This is so in all respects, except one: Hundred of times I have taken a history from a teenage high school student who obviously spoke English well and who
White Coat Hypertension in NIDDM Patients With and Without Incipient and Overt Diabetic Nephropathy
Authors: Flemming S Nielsen, Pernille Gæde, Pernille Vedel, Oluf Pedersen, Hans-Henrik Parving
Journal: Diabetes Care (1997)

OBJECTIVE Early data have suggested a high prevalence of white coat hypertension (∼ 50%) in NIDDM patients. To study this phenomenon further, we determined the prevalence of white coat hypertension in NIDDM patients with normo- or microalbuminuria or with diabetic nephropathy. RESEARCH DESIGN AND METHODS Three groups of hypertensive NIDDM patients (repeated clinic blood pressure &amp;gt; 140/90 mmHg or antihypertensive treatment) attending the Steno Diabetes Center were investigated in a cross-sectional study. Group 1 had normoalbuminuria (a urinary albumin excretion [UAE] rate &amp;lt; 30 mg/24 h, n = 30, age 61 ± 7 [mean ± SD] years, 20 men), group 2 had microalbuminuria (UAE rate 30–300 mg/24 h, n = 51, age 55 ± 7 years, 35 men), and group 3 had diabetic nephropathy (UAE rate &amp;gt; 300 mg/24h, n = 47, 62 ± 7 years, 36 men). If given, all previous antihypertensive medication was withdrawn at least 2 weeks before the study (48%). The prevalence of white coat hypertension (clinic hypertension with normal blood pressure values at home) was determined by comparison of clinic blood pressure (Hawksley Random sphygmomanometer) and the ambulatory daytime (7:00 A.M. to 11:00 P.M.) blood pressure (A&amp;D TM2420). By applying established criteria, white coat hypertension was confirmed if daytime blood pressure was &amp;lt; 135/85 mmHg. RESULTS The clinic blood pressure was 155/86 (SE 3/2) mmHg, 156/89 (2/1) mmHg, and 171/90 (3/2) mmHg in group 1, 2, and 3, respectively (P &amp;lt; 0.05 comparing group 3 with groups 1 and 2). The prevalence of white coat hypertension was significantly higher in group 1 as compared with groups 2 and 3, 23% (95% CI 10–42) vs. 8% (2–19) and 9% (2–20) (P &amp;lt; 0.05), with no difference between the latter two groups. CONCLUSIONS The prevalence of white coat hypertension in normoalbuminuric NIDDM patients resembles that observed in nondiabetic subjects with essential hypertension, whereas the prevalence is significantly lower in NIDDM patients with incipient or overt diabetic nephropathy, suggesting a difference between primary and secondary hypertension.
Plasma adenosine concentration increases during exercise: A possible contributing factor in exercise-induced bronchoconstriction in asthma
Authors: Éva Vizi, Éva Huszár, Zsuzsa Csoma, György Böszörményi-Nagy, Erzsébet Barát, Ildikó Horváth, Irén Herjavecz, Márk Kollai
Journal: Journal of Allergy and Clinical Immunology (2002)