tbuckley/cabot-search huggingface dataset:
Treadmill Stress Test
Authors: RICHARD A. BARDACK
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 February 1977Treadmill Stress TestRICHARD A. BARDACK, M.D.RICHARD A. BARDACK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-2-245_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to comment on "Treadmill Stress Tests As Indicators of Presence and Severity of Coronary Artery Disease" by Goldschlager, Selzer, and Cohn in the September issue (Ann Intern Med85:277-286, 1976). Their conclusion that exercise testing is "an extremely useful procedure, not only as a means of detecting the presence or absence of coronary disease in a qualitative sense, but also as a means of delineating persons with advanced degrees of malignant types of coronary disease" is not supported by their findings. There were 29 patients with isolated left anterior descending disease, half of whom had...Reference1. BRUSCHKE A, PROUDFIT W, and JONES F: Progress study of coronary disease followed 5-9 years. I. Arteriographic correlations. Circulation 47:1147-1153, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD A. BARDACK, M.D.Affiliations: 2550 Windy Hill Road, Suite 203 Marietta, GA 30060 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDictionary of Inorganic Compounds 1 February 1977Volume 86, Issue 2Page: 245-245KeywordsExerciseStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 February 1977 PDF downloadLoading ...
CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis
Authors: David Sancho, Manuel Gómez, Fernando Viedma, Enric Esplugues, Mónica Gordón-Alonso, María Angeles García-López, Hortensia de la Fuente, Carlos Martínez-A, Pilar Lauzurica, Francisco Sánchez-Madrid
Journal: Journal of Clinical Investigation (2003)

CD69 is induced after activation of leukocytes at inflammatory sites, but its physiological role during inflammation remains unknown. We explored the role of CD69 in autoimmune reactivity by analyzing a model of collagen-induced arthritis (CIA) in WT and CD69-deficient mice. CD69–/– mice showed higher incidence and severity of CIA, with exacerbated T and B cell immune responses to type II collagen. Levels of TGF-β1 and TGF-β2, which act as protective agents in CIA, were reduced in CD69–/– mice inflammatory foci, correlating with the increase in the proinflammatory cytokines IL-1β and RANTES. Local injection of blocking anti–TGF-β antibodies increased CIA severity and proinflammatory cytokine mRNA levels in CD69+/+ but not in CD69–/– mice. Moreover, in vitro engagement of CD69 induced total and active TGF-β1 production in Concanavalin A–activated splenocyte subsets, mouse and human synovial leukocytes, and Jurkat stable transfectants of human CD69 but not in the parental CD69 negative cell line. Our results show that CD69 is a negative modulator of autoimmune reactivity and inflammation through the synthesis of TGF-β, a cytokine that in turn downregulates the production of various proinflammatory mediators.
Adverse reactions to nitrofurantoin in the United Kingdom, Sweden, and Holland.
Authors: R G Penn, J P Griffin
Journal: BMJ (1982)

A study was carried out comparing the reporting of adverse reactions to nitrofurantoin in Sweden, Holland, and the United Kingdom. The Swedish drug regulatory authorities receive more reports of adverse reactions to nitrofurantoin than to any other drug, and the annual reporting rate is increasing despite a steady fall in the prescription of nitrofurantoin. In the United Kingdom the total number of adverse reaction to nitrofurantoin reported to the Committee on Safety of Medicines has been steadily falling for many years, as has the number of prescription. Lung reactions and liver damage are more commonly reported in Sweden than in the UK, where gastrointestinal symptoms and peripheral neuropathy are more common. Such figures as were available in Holland showed an intermediate picture. The incidences of blood dyscrasias and allergic reactions are similar in the three countries. The causes for such differences are unresolved, but it is disturbing that the incidence and range of adverse reactions to such a common drug as nitrofurantoin reported to the national authorities can differ so much in countries that have close ethnic, dietary, and economic similarities. Thus great caution must be observed when data on adverse drug reactions from the country are extrapolated to another.
Suppression of Plasminogen Activator Inhibitor-1 Release From Human Cerebral Endothelium by Plasminogen Activators
Authors: Marie A. Shatos, Jacqueline M. Doherty, Paul L. Penar, Burton E. Sobel
Journal: Circulation (1996)

Background Intracranial bleeding is the most catastrophic potential complication of treatment with thrombolytic agents. To identify potential factors that may contribute to this problem, we characterized elaboration by human brain endothelial cells of plasminogen activator inhibitor-1 (PAI-1) and measured PAI-1 mRNA levels. Methods and Results When human cerebral microvascular endothelial cells (HCMEC), pial arterial endothelial cells, and middle meningeal arterial endothelial cells were exposed to 10 to 1000 ng/mL recombinant tissue-type plasminogen activator (RTPA), urokinase-type plasminogen activator (UPA), or streptokinase/plasminogen (37 U streptokinase plus 2 μmol/L plasminogen) for 24 hours, they exhibited concentration-dependent decreases in elaboration of PAI-1 of 65±3%, 48±3%, and 59±8%. UPA and streptokinase/plasminogen elicited decreases of 33±8% and 35±4%, respectively, that were specific with respect to the protease agonists as to total protein synthesis and cell type; ie, neither human umbilical vein endothelial cells nor cerebral pericytes exhibited inhibition of PAI-1 elaboration. No decrease in HCMEC PAI-1 elaboration was induced by coagulation factor Xa (10 nmol/L). A 2.7±0.5-fold increase was induced by α-thrombin (10 nmol/L). PAI-1 secretion from HCMEC decreased within 4 hours of exposure to 100 ng/mL RTPA. In HCMEC exposed to RTPA for 8 hours, PAI-1 mRNA decreased from 176±20 to 43±2.2 pg/μg RNA. Conclusions These results indicate that brain endothelial cells exposed to RTPA exhibit paradoxically diminished elaboration of PAI-1. This property may render brain vasculature vulnerable to attack by serine proteases, thereby predisposing to injury and initiating an underlying subsequent intracerebral hemorrhage in patients given plasminogen activators for treatment of coronary thrombosis.
A time of change in abortion
Authors: Des Spence
Journal: BMJ (2007)

I am a middle class, left wing cliche, and therefore a mass of contradictions. But I am only human. Currently, hostile pressure groups spit at each other over the radio, debating changes to abortion legislation. As a young man I was strongly pro-choice, with black and white opinions. But my opinions have been battered by the weather of time, and only grey uncertainty remains.

Like many doctors I have been directly involved with abortion: I have assisted in the labour suite and in theatre, and in the …
Fluorescence in situ hybridization confirms the presence of Merkel cell polyomavirus in chronic lymphocytic leukemia cells
Authors: Anke Maria Haugg, Ernst-Jan Maria Speel, Naga Deepa Pantulu, Christian Pallasch, Anna Kordelia Kurz, Hans Michael Kvasnicka, Gieri Cathomas, Clemens-Martin Wendtner, Axel zur Hausen
Journal: Blood (2011)

To the editor:

We would like to complement our recently reported data on the detection of the Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia (CLL) cells.[1][1] We have shown that MCPyV could be identified by PCR in highly purified CLL cells of 19 of 70 (27.1%) CLL patients. In 6
Beneficial effects of high-dose diltiazem in patients with persistent effort angina on beta-blockers and nitrates: a randomized, double-blind, placebo-controlled cross-over study.
Authors: W E Boden, E W Bough, M J Reichman, V B Rich, P M Young, K S Korr, R S Shulman
Journal: Circulation (1985)

The effects of orally administered diltiazem combined with maximally tolerated doses of beta-blockers and nitrates were assessed in 12 patients, who during stress testing exhibited persistent effort angina and continued objective evidence for inducible myocardial ischemia. Patients performed multistage semisupine exercise on a bicycle ergometer during equilibrium-gated radionuclide angiography after consecutive 2 week treatment periods of placebo or diltiazem 90 mg qid (mean dose 340 mg/day) combined with maximally tolerated propranolol (mean dose 178 mg/day) and isosorbide dinitrate (mean dose 137 mg/day). All medications (including diltiazem or placebo) were administered four times daily for the duration of the study. Diltiazem or placebo was administered according to a double-blind design, with randomized cross-over at the end of each 2 week treatment period. The average number of angina attacks decreased during the double-blind cross-over phase of the trial (7 +/- 7 episodes/week at baseline vs 4 +/- 3 on placebo vs 2 +/- 2 on diltiazem; p = .08). Angina pectoris was abolished during peak exercise in eight of 12 patients on diltiazem (p less than .05 vs placebo). Diltiazem increased total exercise duration from 276 +/- 92 to 310 +/- 78 sec (p less than .005 vs baseline). Diltiazem likewise increased the time to onset of angina from 231 +/- 84 sec at baseline to 305 +/- 77 sec (p less than .005), as well as the time to the onset of 1 mm ischemic ST segment depression (p = .01). Diltiazem decreased heart rate at rest, during submaximal workload, and at peak exercise (p less than .05), and decreased systolic blood pressure at peak exercise only (p less than .05). A significant decline in rate-pressure product at submaximal and peak exercise was noted (p less than .05). At any given workload there was significantly less ST segment depression during submaximal (p = .05) and peak exercise (p less than .025).(ABSTRACT TRUNCATED AT 250 WORDS)
Thirty-Month Follow-up of Maximal Treadmill Stress Test and Double Master's Test in Normal Subjects
Authors: WILBERT S. ARONOW
Journal: Circulation (1973)

One hundred normal subjects who had a double Master's test and a maximal treadmill stress test (MTST) were clinically evaluated 30 months later. Ninety-nine of these 100 subjects (99%) had a follow-up treadmill test at 30 months. One of four subjects (25%) with initially an abnormal double Master's test developed coronary heart disease within 30 months. Three of 96 subjects (3.1%) with initially a normal double Master's test developed coronary heart disease within 30 months. Three of 13 subjects (23.1%) with initially an abnormal MTST developed coronary heart disease within 30 months. One of 87 subjects (1.1%) with initially a normal MTST developed coronary heart disease within 30 months. The MTST correlated better than the double Master's test in predicting subsequent coronary heart disease.
THE SUBNORMAL AND PSYCHOPATHIC CHILD AS EXEMPLIFIED IN SPECIAL CLINIC
Authors: LOUIS A. LURIE
Journal: JAMA (1923)

Within recent years, much attention has been given to the study of subnormal and psychopathic children. This study has been greatly stimulated by the introduction of the various psychometric tests, especially the Binet-Simon tests, by means of which a workable classification and standardization of subnormal children have been made possible. These tests, being psychologic, account for the fact that for a long time the development of this field has been principally in the hands of psychologists and social workers. Now, however, we are beginning to realize more and more that the whole problem is distinctly a medical one, and concerns primarily the psychiatrist, who, in order to succeed, must aline himself with the pediatrician on the one hand, and with the psychologist and social worker on the other. The whole of life, according to Herbert Spencer, is an adjustment, a continuous adjustment of inner to outer relations, and it is
The Enduring Effect of the Jewish Tradition Upon Freud
Authors: LARY BERKOWER
Journal: American Journal of Psychiatry (1969)

Freud's background included many significant sources of contact with traditional Jewish scholarship. From this background, in part, his intense rational and analytical approach to psychology undoubtedly originated. The author notes remarkable similarities to Jewish scholarship in Freud's determinism, his utilization of metaphorical communication, and his study and interpretation of associations and dreams. Freud proudly acknowledged this influence and inspiration. On the other hand, there is little to indicate that Freud was seriously affected by Jewish cabbalistic and mystical movements, as has been proposed by others.
ATM-ATR–dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
Authors: Alessandra Soriani, Alessandra Zingoni, Cristina Cerboni, Maria Luisa Iannitto, Maria Rosaria Ricciardi, Valentina Di Gialleonardo, Marco Cippitelli, Cinzia Fionda, Maria Teresa Petrucci, Anna Guarini, Robin Foà, Angela Santoni
Journal: Blood (2008)
Embolic Stroke Following Carotid Radiation Angiopathy Demonstrated with 1-123 IMP Brain SPECT
Authors: KOHEI HAYASHIDA, TSUNEHIKO NISHIMURA, SATOSHI IMAKITA, SHIN-ICHIROU KUMITA, TOSHIISA UEHARA, SEIKI HAMADA
Journal: Clinical Nuclear Medicine (1991)

Radiation angiopathy was developed by the process of accelerated atherosclerosis at the site of irradiation. The case of a 44-year-old man with right hemiparesis showing a high signal intensity in the left semioval center on MRI and a defect in the left temporo-parietal area with subsequent filling-in with 1–123 IMP brain SPECT is reported. Digital subtraction angiography showed typical radiation angiopathy with ulceration in the left common carotid artery. Twenty-four years previously, he underwent curative irradiation of a neck mass that revealed Hodgkin's disease by biopsy. The emboli formed at the site of radiation-induced angiopathy and caused cerebral infarction. The perfusion abnormality in the territory of theembolic artery was detected by 1–123 IMP SPECT. Long-term survivors of neck irradiation are at high risk for the development of carotid arterial disease and should be watched carefully.
Reform of Continuing Medical Education
Authors: Eric G. Campbell, Meredith Rosenthal
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Users' guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid? Evidence-Based Medicine Working Group
Authors: G. H. Guyatt
Journal: JAMA (1993)

<h3>CLINICAL SCENARIO</h3> You are working as an internal medicine resident in a rheumatology rotation and are seeing a 19-year-old woman who has had systemic lupus erythematosus diagnosed on the basis of a characteristic skin rash, arthritis, and renal disease. A renal biopsy has shown diffuse proliferative nephritis. A year ago her creatinine level was 140 μmol/L, 6 months ago it was 180 μmol/L, and in a blood sample taken a week before this clinic visit, 220 μmol/L. Over the last year she has been taking prednisone, and over the last 6 months, cyclophosphamide, both in appropriate doses. You are distressed by the rising creatinine level and the rheumatology fellow with whom you discuss the problem suggests that you contact the hematology service to consider a trial of plasmapheresis. The fellow states that plasmapheresis is effective in reducing the level of the antibodies responsible for the nephritis and cites a number
The Cranial Mononeuropathies
Authors: J. M. Foley
Journal: New England Journal of Medicine (1969)

Dysfunction of a cranial nerve can bring fear to the patient and panic to the doctor. It requires only a little imagination for the patient to extend diplopia to amblyopia, vertigo to total immobility, facial paresis to total disfigurement, or dysphagia to inanition. The physician, confronted with such a patient, becomes like a reluctant spelunker, fearing to search for a diagnosis in the endless caves and tunnels of the skull and the branched and controversial pathways of the brain-stem. The "R/O" list at the end of the intern's write-up loses any pretense of restraint when a nerve above the neck . . .
Regulation of Growth, and Its Relation to Cancer.
Authors: Paul Zamecnik
Journal: Annals of Internal Medicine (1967)

s1 May 1967Regulation of Growth, and Its Relation to Cancer.Paul Zamecnik, M.D.Paul Zamecnik, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1066_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe flow of information from the gene is not under normal circumstances continuous and uncontrolled but is subject to regulation, which ensures that the synthesis of new enzymes and the construction of new cells occur at the right time. It has become a central problem for molecular biology to define the nature of these control mechanisms that keep the normal cell, or, in larger terms, the multicellular animal, functioning as a well-disciplined unit. Cancer research has also precisely the same long-range goal. One of the most dramatic ways in which the normal metabolism of a cell may be upset is... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1066-1066KeywordsCell metabolismCellsEnzymesMolecular biology Issue Published: 1 May 1967 PDF downloadLoading ...
An open and shut case
Authors: B Dixon
Journal: BMJ (1994)

My most disquieting experiences on the lecture podium were addressing (a) a woman snoring loudly in the front row of Liverpool's Royal Institution, and (b) a young man yawning more or less continuously for 45 minutes at the University of Bristol.

He was by far the worse of the two, but why was he yawning? The more one wonders about being yawned at, the less clear the answer becomes. When a person yawns, just as we are trying to say something significant, is it a neurophysiological consequence or their boredom? Or are they consciously telling us that they are bored? Certainly boredom and drowsiness are each associated with yawning. Yet there is no decent evidence that these things are causally related.

So the issue broadens: what is yawning for anyway? …
Recent Trends in Suicide and Homicide Among Blacks
Authors: Ezra E. H. Griffith, Carl C. Bell
Journal: JAMA (1989)

The black community contends daily with the phenomena of suicide and homicide. However, it is the killing of black males that constitutes the heaviest burden for the group. Black suicide rates, on the other hand, continue to be lower than white suicide rates. Nevertheless, it is the black male group between the ages of 25 and 34 years that bears the brunt of both suicide and homicide. This article reviews the major theories advanced to explain the existence of these serious public health problems in the black community, suggests ways of attacking these problems, and also delineates significant areas for future research. (<i>JAMA</i>. 1989;262:2265-2269)
Poor Results of 5-Aminolevulinic Acid-Photodynamic Therapy for Residual High-Grade Dysplasia and Early Cancer in Barrett Esophagus after Endoscopic Resection
Authors: F. Peters, M. Kara, W. Rosmolen, M. Aalders, F. ten Kate, K. Krishnadath, J. van Lanschot, P. Fockens, J. Bergman
Journal: Endoscopy (2005)

Background and Study Aims: The aim of the study was to evaluate the efficacy of photodynamic therapy (PDT) in the treatment of residual high-grade dysplasia or early cancer (HGD/EC) after endoscopic resection in Barrett esophagus. Patients and Methods: Study patients were separated into group A, with proven residual HGD/EC, and group B with possible HGD/EC (positive lateral margins in the endoscopic resection specimen, without HGD/EC in the remaining Barrett esophagus). PDT treatment consisted of 5-aminolevulinic (5-ALA) photosensitization (40 mg/kg) followed by illumination of the Barrett esophagus with a total light dose of 100 J/cm2. Complete remission was defined as the absence of HGD/EC in biopsies taken in two consecutive follow-up endoscopies. The percentage regression of Barrett esophagus, as well as the recurrence rate of HGD/EC, was calculated.
THE RELATIONSHIP BETWEEN THE MAGNITUDE OF REDUCTION IN MITRAL REGURGITATION SEVERITY AND LEFT VENTRICULAR AND LEFT ATRIAL VOLUMES POST-TREATMENT WITH THE MITRACLIP DEVICE
Authors: Paul Grayburn, Chithra Sangli, Joseph Massaro, Laura Mauri, Neil Weissman, Donald Glower, Ted Feldman, Elyse Foster
Journal: Journal of the American College of Cardiology (2012)
False-Positive Lung Imaging: Inadvertent Injection Into a Pulmonary Artery Catheter
Authors: MICHAEL BRACHMAN, DOINA TANASESCU, LALITHA RAMANNA, DANIEL BERMAN, ALAN WAXMAN
Journal: Clinical Nuclear Medicine (1979)

A case of a ventilation-perfusion mismatch seen postoperatively in a patient with chest pain is reported. There was absence of perfusion to the right lung, with relatively normal ventilation. The study was initially interpreted as indicating a high probability of pulmonary embolus. It was then discovered that the injection had been inadvertently made into a Swan-Ganz catheter, with its tip in the left main pulmonary artery. The mismatch was therefore iatrogenic and not related to pulmonary embolus. The false-positive lung imaging which resulted has not been previously reported in the literature.