tbuckley/cabot-search huggingface dataset:
SPECTROSCOPIC AND CHEMICAL DEMONSTRATIONS OF OCCULT BLOOD IN THE FECES
Authors: CHARLES D. AARON
Journal: JAMA (1924)

The finding of occult blood in the feces, when hemorrhage from the nose, mouth, throat, esophagus and hemorrhoids can be eliminated, is of the highest importance in the diagnosis of ulceration of the digestive tract. In conjunction with certain clinical symptoms, occult blood may be looked on as pathognomonic of ulcerating lesions of the stomach or the intestine. Moreover, in cases of gastric ulcer, occult blood in the feces is a most important objective symptom, for it not only clinches the diagnosis, but also indicates whether or not the ulcer is healing. During the treatment, a negative test for occult blood implies that the therapy is effective. The finding of occult blood is also the earliest and surest objective symptom in cases of carcinoma of the digestive tract. Bleeding from a carcinoma can be differentiated from bleeding from an ordinary ulcer by the fact that, in ulcer, the bleeding may
Aseptic Necrosis of Bone in Myxedema
Authors: HERBERT M. RUBINSTEIN
Journal: Annals of Internal Medicine (1977)

Brief Reports1 November 1977Aseptic Necrosis of Bone in MyxedemaHERBERT M. RUBINSTEIN, M.D., F.A.C.P., MARION H. BROOKS, M.D., F.A.C.P.HERBERT M. RUBINSTEIN, M.D., F.A.C.P.Search for more papers by this author, MARION H. BROOKS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-5-580 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGrowth retardation and delayed skeletal maturation are well-known manifestations of cretinism and juvenile myxedema. Patients with these conditions have abnormal ossification of epiphyseal centers that may appear porous, stippled, or fragmented on roentgenogram (epiphyseal dysgenesis). These changes are most pronounced in large ossification centers such as the femoral head and tarsal navicular. In the femoral head, clinical and radiographic features resemble Legg-Calvé-Perthes disease, but there are marked differences in pathology and response to thyroid hormone administration (1, 2). In the adult, thyroid hormone deficiency is associated with decreased metabolic activity and remodeling of bone (2), but overt skeletal disease has...References1. WILKINS L: Epiphyseal dysgenesis associated with hypothyroidism. Am J Dis Child 61:13-34, 1941 Google Scholar2. SOBELBRAUNWALD BE: Cardiovascular system in hypothyroidism, in The Thyroid. A Fundamental and Clinical Text, 3rd ed., edited by WERNER SC, INGBAR SH. New York, Harper and Row, 1971, pp. 727-733 Google Scholar3. DAVIDSON J (ed.): Aseptic Necrosis of Bone. Amsterdam, Exerpta Medica, 1976, pp. 3-269 Google Scholar4. ZINN W (ed.): Idiopathic Ischemic Necrosis of the Femoral Head in Adults. Baltimore, University Park Press, 1971, pp. 1-157 Google Scholar5. KÖHLERZIMMER AE: Borderlands of the Normal and Early Pathologic in Skeletal Roentgenology, 3rd American ed. based on 11th German ed. New York, Grune and Stratton, 1968 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Loyola University Stritch School of Medicine Maywood, IL 60153 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPituitary and Thyroid DisordersFreiberg’s Infraction in Identical Twins: A Case ReportBone and joint manifestations of hypothyroidismThyroïde et affections ostéo-articulaires. Associations pathologiques chez l'adulteEndocrine ArthropathiesExperimental models 1 November 1977Volume 87, Issue 5Page: 580-581KeywordsBoneBone remodelingClinical pathologyMetabolic disordersNecrosisThyroid hormones Issue Published: 1 November 1977 PDF DownloadLoading ...
FRACTURE OF PATELLA.RESTORATION OF FUNCTION IN SPITE OF NON-TREATMENT.
Authors: J. B. CUTTER
Journal: JAMA (1905)

J. L., Mexican, laborer, aged 40, entered Santa Fé Hospital April 17, with fracture of left patella at lower one-third. After remaining in bed until April 20, when the extreme effusion had somewhat subsided, on being told of the length of time necessary for repair, entailing several weeks' confinement to bed, the patient precipitately left the hospital, refusing further treatment or advice. On May 23 he again presented himself at the hospital for the necessary certificate of discharge for reinstatement in his position. The leg had been in constant use in the interim. No effort at treatment or immobilization having been made. In the absence of effusion, the deep sulcus separating the fragments was clearly demonstrated, the distance between the fragments being about three-quarters of an inch, with apparently a thin band of ligamentous union present. The function, however, was remarkably good, there being almost complete extension and no inconvenience
Improvement in Cardiac Function With Small Intestine Extracellular Matrix Is Associated With Recruitment of C-Kit Cells, Myofibroblasts, and Macrophages After Myocardial Infarction
Authors: Zhi-Qing Zhao, John D. Puskas, Di Xu, Ning-Ping Wang, Mario Mosunjac, Robert A. Guyton, Jakob Vinten-Johansen, Robert Matheny
Journal: Journal of the American College of Cardiology (2010)
CLINICAL AND ROENTGEN-RAY STUDY OF TUBERCULOUS BRONCHO-ADENOPATHY
Authors: THOMPSON FRAZER
Journal: JAMA (1923)

With the realization that tuberculosis commonly has its inception during the earlier years of life, physicians, so long concerned chiefly with the diagnosis and treatment of tuberculosis in adults, are now focusing their attention to a greater degree on the manifestations of this disease in childhood, and particularly on that form known as tuberculous tracheobronchial adenopathy. During the last few years, studies looking toward an earlier diagnosis of childhood tuberculosis have resulted in the accumulation of such a mass of data that we have thought it wise to attempt an evaluation of the various signs, symptoms and tests which have a bearing on the diagnosis of this condition. The data which relate to the diagnosis of childhood tuberculosis comprise: (1) a history of exposure to infection; (2) the Pirquet skin test; (3) symptoms; (4) physical signs, and (5) roentgen-ray findings. <h3>EXPOSURE TO INFECTION</h3> Although it may appear heretical to say
Taste masking of ciprofloxacin by ion-exchange resin and sustain release at gastric-intestinal through interpenetrating polymer network
Authors: A. Michael Rajesh, Shreya A. Bhatt, Harshad Brahmbhatt, Pritpal Singh Anand, Kiritkumar Mangaldas Popat
Journal: Asian Journal of Pharmaceutical Sciences (2015)

The aim of the study was to taste mask ciprofloxacin (CP) by using ion-exchange resins (IERs) followed by sustain release of CP by forming interpenetrating polymer network (IPN). IERs based on the copolymerization of acrylic acid with different cross linking agents were synthesised. Drug-resin complexes (DRCs) with three different ratios of drug to IERs (1:1, 1:2, 1:4) were prepared & evaluated for taste masking by following in vivo and in vitro methods. Human volunteers graded ADC 1:4, acrylic acid-divinyl benzene (ADC-3) resin as tasteless. Characterization studies such as FTIR, SEM, DSC, P-XRD differentiated ADC 1:4, from physical mixture (PM 1:4) and confirmed the formation of complex. In vitro drug release of ADC 1:4 showed complete release of CP within 60 min at simulated gastric fluid (SGF) i.e. pH 1.2. IPN beads were prepared with ADC 1:4 by using sodium alginate (AL) and sodium alginate-chitosan (AL-CS) for sustain release of CP at SGF pH and followed by simulated intestinal fluid (SIF i.e. pH 7.4). FTIR spectra confirmed the formation of IPN beads. The release of CP was sustain at SGF pH (<20%) whereas in SIF media it was more (>75%). The kinetic model of IPN beads showed the release of CP was non-Fickian diffusion type.
Management of Skin and Soft-Tissue Infection — Polling Results
Authors: Sarah P. Hammond, Lindsey R. Baden
Journal: New England Journal of Medicine (2008)

In early September, we presented a case of a college athlete with a skin and soft-tissue infection in Clinical Decisions,1 an interactive feature designed to assess how readers would manage a clinical problem for which there may be more than one appropriate treatment. Our patient was a healthy 20-year-old college basketball player who presented with a tender erythematous area on the right buttock. He reported that there was no direct trauma to the area. He had traveled throughout the United States for basketball games over the previous several weeks. He noted having subjective low-grade fevers the night before presentation and . . .
IDH2 somatic mutations in chronic myeloid leukemia patients in blast crisis
Authors: S Soverini, J Score, I Iacobucci, A Poerio, A Lonetti, A Gnani, S Colarossi, A Ferrari, F Castagnetti, G Rosti, F Cervantes, A Hochhaus, M Delledonne, A Ferrarini, M Sazzini, D Luiselli, M Baccarani, N C P Cross, G Martinelli
Journal: Leukemia (2010)
A Simple Means of Anatomic Correlation of the Photo Dot Scan
Authors: Fred Mishkin
Journal: New England Journal of Medicine (1965)

THE especial usefulness of isotopic brain scanning with gamma emitters stems from its simplicity and high degree of accuracy, which rivals that of the technically more difficult procedures of angiography and air-contrast studies.1 , 2 Occasionally, the scan detects a lesion that is not manifested by the other more precise diagnostic studies, and then the scan along with the clinical findings must provide the basis for a therapeutic decision. When surgery is indicated precise anatomic localization is necessary. Superimposition of the scan over the routine radiograph provides a convenient but cumbersome means of anatomically localizing detected lesions. The distortion due to projectional . . .
Vasectomy and Adverse Psychological Reactions
Authors: FREDERICK J. ZIEGLER
Journal: Annals of Internal Medicine (1970)

Editorial Notes1 November 1970Vasectomy and Adverse Psychological ReactionsFREDERICK J. ZIEGLER, M.D.FREDERICK J. ZIEGLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-5-853 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the recent adverse publicity concerning ovulation suppressor contraception, there is reason to believe that there has been a major epidemic of unwanted pregnancies and, for many couples, an increase in requests for vasectomy as the most acceptable contraceptive option. A review of the evidence concerning possible psychological upset after vasectomy may therefore be timely. There have been several reports of psychiatric problems after and apparently related to vasectomy (1). Most questionnaire surveys made of couples after vasectomy report almost complete satisfaction with the procedure as a contraceptive method (2). In a follow-up study of some patients who had help...References1. JOHNSON M: Social and psychological effects of vasectomy. Amer J Psychiat 121:482-486, 1964 CrossrefMedlineGoogle Scholar2. LANDISPOFFENBERGER JT: The marital and sexual adjustment of 330 couples who chose vasectomy as a form of birth control. J Marriage Family 27:57-58, 1965 CrossrefGoogle Scholar3. FERBERTIETZELEWIT SCS: Men with vasectomies: a study of medical, sexual, and psychosocial changes. Psychosom Med 29:354-366, 1967 CrossrefMedlineGoogle Scholar4. RODGERSZIEGLERALTROOCHI DFJ: A longitudinal study of the psycho-social effects of vasectomy. J Marriage Family 27:59-64, 1965 CrossrefGoogle Scholar5. ZIEGLERRODGERSPRENTISS FDR: Psychosocial response to vasectomy. Arch Gen Psychiat (Chicago) 21:46-54, 1969 CrossrefMedlineGoogle Scholar6. RODGERSZIEGLER DF: Changes in sexual behavior consequent to use of noncoital procedures of contraception. Psychosom Med 30:495-505, 1968 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mental Health Center Community Hospital of the Monterey Peninsula Carmel, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCircumcision and Vasectomy: Do They Affect Sexual Function?Oxprenolol and retroperitoneal fibrosis.Homosexual behaviour after vasectomy.VasectomyMale SterilizationPsychological Dynamics and Self-Perceptions of Vasectomy CandidatesHospital family planning: A vasectomy serviceA Factor Analysis of Contraceptive Preferences 1 November 1970Volume 73, Issue 5Page: 853-853KeywordsAdverse reactionsContraceptivesFemale contraceptionOvulationPregnancyQuestionnairesVasectomy Issue Published: 1 November 1970 PDF DownloadLoading ...
Biological Basis of Alcoholism
Authors: Donald W. Goodwin
Journal: JAMA (1972)

Without any trouble at all, you could have spent $116.45 on books about alcohol last year, roughly the amount required to buy 30 bottles of bourbon, Missouri prices. It is a sobering thought. Here are the books, in order of appearance:<i>Actions of Alcohol, Volumes I and II</i>, by H. Wallgren and H. Barry, Amsterdam, Elsevier Publishing Company, 1970, $64;<i>The Biology of Alcoholism</i>, Vol 1:<i>Biochemistry</i>, edited by B. Kissin and H. Begleiter, New York, Plenum Press, 1971, $32.50; and the present one. These are the good books. There were also pretty good books and some bad ones, but the above are books too good, almost,<i>not</i>to buy. Each is scholarly, thorough, superbly documented. Each says pretty much what the others say, and it would be hard to recommend one over the others. Why try? For "boozologists" it has been a vintage year. The books deal more with
AORTIC REGURGITATION: PROGNOSTIC VALUE OF PREOPERATIVE SYMPTOMS FOR POST-VALVE REPLACEMENT SURVIVAL IS MODULATED BY MYOCARDIAL CONTRACTILITY
Authors: Jeffrey Borer, Phyllis Supino, Edmund Herrold, Clare Hochreiter, O. Wayne Isom, Karl Krieger, Leonard Girardi, Nasimullah Khan, Daniel Santarsieri
Journal: Journal of the American College of Cardiology (2014)
A review of nutrition and performance of hard physical work
Authors: J. D. Brooke, G. J. Davies
Journal: British Journal of Sports Medicine (1973)

Despite the folk-lore surrounding athletic diets experimental evidence shows that an increase in protein intake is not used for the provision of energy in working muscles.Any extra amount of protein required for the increase in muscle mass is provided in the normal diet.Carbohydrate and fat provide the sources of muscular energy, fat being important at low intensities of work and during work of long duration.The proportion of carbohydrate used increases with increasing work intensity or with an increase in dietary carbohydrate.Most of the carbohydrate for exercise is supplied by the local glycogen stores in skeletal muscle and with hard physical work over hours these stores are depleted and the subject becomes exhausted.The initial store of muscle glycogen can be altered by changes in diet and with combinations of exercise and diet.These can be summarized as:1.A carbohydrate rich diet prior to work will greatly increase the duration of work.2. Feeding carbohydrate during work increases the duration of work.3. Following exercise to exhaustion a high carbohydrate diet increases the glycogen stores more quickly and to higher levels than other diets.4. An exercise adaptation can occur.Following successive bouts of work to exhaustion subjects on a normal mixed diet worked longer on their last ride with a greater use of the carbohydrate stores.
Lymphoscintigraphy as an Adjunctive Procedure in the Perioperative Assessment of Patients Undergoing Microlymphaticovenous Anastomoses
Authors: GLYNIS A. SACKS, MARTIN P. SANDLER, MARK L. BORN, JEFF A. CLANTON, JOHN D. FRANKLIN, C LEON PARTAIN
Journal: Clinical Nuclear Medicine (1983)

Microlymphaticovenous anastomoses provide a potential for reducing lymphedema of the upper extremity complicating radical mastectomy or irradiation. Lymphoscintigraphy is a valuable investigative modality in the perioperative evaluation of patients undergoing this surgical procedure. The radionuclide studies provide information regarding structural change and physiologic derangement with a low radiation dose to the patient. It is a simple, painless procedure requiring minimal skill and no surgical intervention. In addition, a reproducible method for preparing a radiocolloid suitable for lymphatic imaging using an approved drug as a precursor has been developed.
Effect of pressure and volume overload on proto-oncogene expression in the isolated working rat heart
Authors: C Kolbeck-Ruhmkorff, A Horban, H-G Zimmer
Journal: Cardiovascular Research (1993)

Journal Article Effect of pressure and volume overload on proto-oncogene expression in the isolated working rat heart Get access C Kolbeck-Rühmkorff, C Kolbeck-Rühmkorff Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 München, Germany: C Kolbeck-Rühmkorff, A Horban, H-G Zimmer. Correspondence to Professor H-G Zimmer. Search for other works by this author on: Oxford Academic PubMed Google Scholar A Horban, A Horban Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 München, Germany: C Kolbeck-Rühmkorff, A Horban, H-G Zimmer. Search for other works by this author on: Oxford Academic PubMed Google Scholar H-G Zimmer H-G Zimmer Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 München, Germany: C Kolbeck-Rühmkorff, A Horban, H-G Zimmer. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 11, November 1993, Pages 1998–2004, https://doi.org/10.1093/cvr/27.11.1998 Published: 01 November 1993 Article history Received: 24 March 1993 Accepted: 20 July 1993 Published: 01 November 1993
Altered cardiovascular and neurohumoral responses to head-up tilt after heart-lung transplantation.
Authors: N R Banner, T D Williams, N Patel, J Chalmers, S L Lightman, M H Yacoub
Journal: Circulation (1990)

Heart-lung transplantation results in afferent and efferent denervation of the transplanted organs including interruption of the central connections from the low-pressure receptors in the atria and pulmonary veins. We investigated whether the cardiovascular and neurohumoral responses to the postural stimulus of head-up tilt were affected after transplantation. Responses in eight heart-lung transplant recipients were studied and compared with those in eight normal subjects matched for age and sex during passive head-up tilt at 45 degrees for 1 hour. The transplant group had a higher initial heart rate (99 +/- 2 versus 68 +/- 2 beats/min, p less than 0.001) and diastolic blood pressure (88 +/- 5 versus 76 +/- 2 mm Hg, p less than 0.05) than did the control group. The increases in heart rate and diastolic blood pressure during head-up tilt were similar in the two groups. Systolic blood pressure remained unchanged. The decrease in cardiac output (30% versus 18%, p less than 0.05) and the increase in systemic vascular resistance (52% versus 28%, p less than 0.05) were greater in the transplant group. Baseline levels of norepinephrine, epinephrine, vasopressin, and plasma renin activity were similar in the two groups. Atrial natriuretic peptide concentrations were higher in the transplant group (26 +/- 3.8 versus 9.7 +/- 1.6 pmol/l, p less than 0.001). During head-up tilt, plasma norepinephrine levels increased to a greater extent in the transplant group than in the control group (83% versus 53%, p less than 0.01), indicating an increased sympathetic response. In contrast, plasma renin activity increased significantly in the control group but not in the transplant group.(ABSTRACT TRUNCATED AT 250 WORDS)
THE EFFECT OF SMOKING ON THE CARBON MONOXIDE CONTENT OF BLOOD
Authors: H. B. HANSON
Journal: JAMA (1933)

A careful study of the carbon monoxide content of the blood of normal individuals living in New York City has recently been made by Gettler and Mattice, 1 and the suggestion is made that smoking is apt to be  the most conspicuous factor in determining the carboxy-hemoglobin of an individual under normal conditions when he is not exposed to obvious high percentages of carbon monoxide.  Similar observations made at the same time in Chicago confirm this conclusion. Analyses of the carbon monoxide content of venous blood were made on the Van Slyke manometric blood gas apparatus according to the technic of Sendroy and Liu. 2 Gasometric determinations of the oxygen capacity of the blood were also made in order that the percentage of saturation of the blood with carbon monoxide might be calculated. Determinations were carried out in duplicate.    Normal individuals who do not use tobacco and who are not
Effectiveness of Right Heart Catheterization: Time for a Randomized Trial
Authors: Jeffrey D. Punch
Journal: JAMA (1997)

To the Editor.  —Drs Dalen and Bone 1 recommend that either a randomized trial be conducted to determine if pulmonary artery (PA) catheterization is beneficial or the FDA should issue a moratorium on the use of flow-directed PA catheters. This recommendation was based largely on the findings of Dr Connors and the SUPPORT Investigators 2 that patients with PA catheters had a higher associated mortality and hospital cost. However, this study did not include large numbers of patients who are commonly managed with RHC: patients undergoing major surgical procedures, patients with major burns, and patients with severe trauma. Although these patients are at risk for mortality, they do not qualify as having organ system failure.  Several prospective randomized studies in surgical patients have demonstrated benefits of PA catheterization in selected patient populations. 3-5 While Connors et al may have cast doubt on the benefits of PA catheters in a group of patients with
Radiotherapy With Moving-Strip Technique for Testicular Tumors Metastatic to the Lungs
Authors: Norman Simon
Journal: JAMA (1966)

In two long-surviving patients with metastatic testicular tumors, the entire thorax was treated using moving-strip radiation. In this method, a narrow field is treated to a high dose each day, and the field is moved on the patient each succeeding treatment day until the whole volume has been irradiated. The patients tolerated the treatments unusually well, but radiation damage to the lungs developed, mild in the patient surviving 3 1/2 years, and more severe in the other. The histological diagnosis of the primary testis tumor is not a certain guide to radiosensitivity or histological type of the pulmonary metastases. Therefore, we advocate a test dose of radiation to a small lung metastasis to be assured of its radiosensitivity before embarking on moving-strip therapy.
Fatal airway obstruction in infectious mononucleosis.
Authors: S J Fraser, G H Sharwood-Smith
Journal: BMJ (1986)

sibility offuture spinal deformity, which can be the consequence of conservative management.Finally, it is our experience that after the early postoperative period the pain associated with the fracture is less with internally fixed spines than in those conservatively managed.No matter what hospital management is finally embarked on, the important aspect of the care of a potentially unstable spinal injury is, firstly, to recognise that this possibility exists and, secondly, to transport the patient without risking dis- placement of the spine by using the techniques described in the article.