tbuckley/cabot-search huggingface dataset:
910 CANCER STEM CELL ACTIVATION IN HCC AFTER TRANS-ARTERIAL CHEMOEMBOLIZATION (TACE)
Authors: C. Zen, Y. Zen, R.R. Mitry, D. Corbeil, J. Karbanova, J. O'grady, N. Heaton, B. Portmann, A. Quaglia
Journal: Journal of Hepatology (2010)
Regional Cerebral Blood Flow Changes in Chronic Alcoholism Using Tc-99m HMPAO SPECT
Authors: BELKIS ERBAS, COSKUN BEKDIK, G??NAYDIN ERBENG, TAYFUN EN??NL??, SUAT AYTAC, HAKAN KUMBASAR, YILDIRIM DOGAN
Journal: Clinical Nuclear Medicine (1992)

Twenty-eight patients were studied for regional cerebral blood flow changes as a result of chronic alcoholism. After the administration of 550 to 600 MBq Tc-99m HMPAO, tomographic slices were obtained using a SPECT camera. Eight regions per hemisphere were drawn on each transaxial section, and tracer redistribution was calculated for each region. Region-to-whole slice ratios were determined for each patient. Patients had significantly decreased frontal/whole slice (1 ± 0.02) ratios in comparison with a normal group (p< 0.01). Twenty-four out of 26 patients (85.7%) demonstrated abnormal rCBF. Eighteen out of 28 (64.3%) showed activity lower in the left hemisphere than in the right. Using CT parameters, 60% of the patients had either sulcal widening and/or ventricular enlargement. The frontal region and the left hemisphere were more affected by alcohol than other regions. More cerebral blood flow changes than morphologic changes were found caused by alcoholism.
STAT5 deficiency does not affect the expression of glutamine synthetase in mouse liver
Authors: Theodorus B. M. Hakvoort, Jacqueline L. M. Vermeulen, Wouter H. Lamers
Journal: Hepatology (2007)

In a recent study in HEPATOLOGY, Werth et al.1 reported that STAT5 is a transcription factor, which binds to a section of the upstream regulatory region of the glutamine synthetase (GS) gene that, in transfection experiments, enhances reporter-gene expression. The next obvious step to further develop this hypothetical mechanism is to study STAT5 knockout mice and establish if STAT5 signaling in the liver is indeed necessary to mediate GS expression in mammalian liver. Some years ago, we addressed this question in the STAT5 knockout mouse models developed in the laboratory of Dr. Ihle.2 At the time, we studied GS mRNA expression in STAT5a+/+/b+/+, STAT5a−/−/b+/+, STAT5a+/+/b−/−, and STAT5a−/−/b−/− livers with a quantitative in situ hybridization technique.3 The expression pattern and quantification of GS mRNA in these livers is shown in Fig. 1. Mice lacking the STAT5a protein tended to show slightly higher GS mRNA levels (integrated OD = 0.921 and 0.875 for STAT5a−/−/b+/+ and STAT5a−/−/b−/− livers, respectively) compared to mice expressing the STAT5a protein (OD = 0.652 and 0.692 for STAT5a+/+/b+/+ and STAT5a+/+/b−/− livers, respectively). Figure 1 unequivocally shows that deficiency of either STAT5a or STAT5b, or both, does not diminish the expression of GS in mouse liver. Our findings, of course, do not question the identity of the protein isolated and characterized by Werth et al., but complement their data by demonstrating redundancy at the STAT5 site of the signaling cascade that regulates expression of the GS gene. Expression of GS mRNA in STAT5-deficient mouse livers. Liver sections were probed in one and the same session for the presence of GS mRNA with [35S]-labeled cRNA exactly as described.3 These livers were kindly provided by Dr J. Ihle (St. Jude Children's Research Hospital, Memphis, TN). The genetic identity of the liver in each section was reconfirmed by PCR genotype analysis of the wild-type a+ and b+ and the disrupted a− and b− alleles. The analysis was performed on DNA extracted from the paraffin sections, using primers described in Teglund et al.2 The graphs show the GS mRNA expression in STAT5a+/+/b+/+, STAT5a−/− +/+, STAT5a+/+/b−/−, and STAT5a−/−/b−/− (triangle), measured as described in Ruijter et al.4 OD values are linearly related to the GS mRNA concentration after subtraction of technical background signal. The integrated OD is shown in the inset. The data show that GS mRNA in STAT5a+/+/b+/+, STAT5a−/−/b+/+, STAT5a+/+/b−/−, and STAT5a−/−/b−/− livers is only present in an equally wide rim of hepatocytes surrounding the central vein (CV). Furthermore, the analysis shows that the mRNA concentration in these hepatocytes does not depend on the presence or absence of STAT5a or STAT5b. CV, central vein; PV, portal vein. Scale bar: 100 μm. Theodorus B. M. Hakvoort*, Jacqueline L. M. Vermeulen*, Wouter H. Lamers*, * AMC-Liver Center, Academic Medical Center, Amsterdam, The Netherlands.
Measuring systemic effects of inhaled beclomethasone.
Authors: O. Jolobe
Journal: Thorax (1996)

Book reviews stinal lymphadenopathy is not surprising.Paediatric series have emphasised the usefulness of bronchoscopy for the diagnosis of endobronchial disease associated with medi- astinal lymph node tuberculosis.2In adults Auregan et al reported that only three from a series of 140 patients with tuberculous medi- astinal lymphadenopathy had a normal fibr- eoptic bronchoscopic examination and that 135 patients had one or more bronchial fistu- lae.3We therefore agree with Baran and col- leagues that bronchoscopy is of significant diagnostic value in patients with isolated tuberculous mediastinal lymphadenopathy and may avoid more invasive procedures such as mediastinoscopy.However, rigid bron- choscopy with large sampling and/or trans- bronchial biopsy is probably not necessary in most patients.We believe that fibreoptic bronchoscopy with bronchial biopsy speci- mens should be considered as a first line examination in patients with apparently isolated tuberculous mediastinal lymphadenopathy.
Acute effects of biventricular pacing on noninvasive parameters of left ventricular systolic function
Authors: Zoran B. Popovic, Richard A. Grimm, George Perlic, Edward Chinchoy, Jing Ping Sun, Erwan Donal, Neil L. Greenberg, Bruce Wilkoff, James D. Thomas
Journal: Journal of the American College of Cardiology (2002)
Physicians and Pharmaceutical Sales Representatives
Authors: Gil Price
Journal: JAMA (1995)

<h3>To the Editor.</h3> —As a physician previously responsible for pharmaceutical sales training, I would like to respond to the article by Dr Ziegler and colleagues<sup>1</sup>on the accuracy of sales information. My former company (Glaxo Wellcome Inc) strongly supports the position enunciated by Orlowski and Wateska.<sup>2</sup>Patients have a right to expect that a service or product is recommended or prescribed because it is needed and because it is the most efficacious, the safest, and the most cost-effective, based on sound professional judgment. Glaxo has made a major effort to ensure that its representatives are trained to the highest professional standards to impart accurately and comprehensively the medical and technical knowledge that physicians require to use the company's products in their patients' best interests. With the development of new, more effective medicines with novel modes of action, company representatives have an important role in educating physicians in all
Hispanics with End-Stage Renal Disease
Authors: Stephen E. Radecki
Journal: Annals of Internal Medicine (1994)

Letters1 November 1994Hispanics with End-Stage Renal DiseaseStephen E. Radecki, PhD and Allen R. Nissenson, MDStephen E. Radecki, PhDSearch for more papers by this author and Allen R. Nissenson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-9-199411010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent National Institutes of Health consensus conference statement on the morbidity and mortality of renal dialysis noted that whereas the incidence of treated end-stage renal disease is dramatically higher for African-Americans and Native Americans than for other racial groups [1], a clinical impression of greater treated incidence in Hispanics could not be confirmed because of the unavailability of data on ethnicity in the United States Renal Data System [2]. National data from our 1980s dialysis practice study show that Hispanics accounted for 7.6% of the population of treated patients with end-stage renal disease at that time ...References1. Consensus Development Conference Development Panel. Morbidity and mortality of renal dialysis: an NIH consensus conference statement. Ann Intern Med. 1994; 121:62-70. Google Scholar2. U.S. Renal Data System, USRDS 1993 Annual Data Report. Bethesda, Maryland: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 1993. Google Scholar3. Radecki SE, Nissenson AR. Dialysis for chronic renal failure: comorbidity and treatment differences by disease etiology. Am J Nephrol. 1989; 9:115-23. Google Scholar4. U.S. Bureau of the Census. Statistical Abstract of the United States: 1992. 112th ed. Washington, D.C.; 1992. Google Scholar5. Sorlie PD, Backlund E, Johnson NJ, Rogot E. Mortality by Hispanic status in the United States. JAMA. 1993; 270:2464-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPrevalence of chronic kidney disease in an urban Mexican population 1 November 1994Volume 121, Issue 9Page: 723-724KeywordsHispanic peopleMedical dialysisMorbidityMortalityNative American peopleRacial and ethnic issuesRenal failureRenal system Issue Published: 1 November 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Fusion of bone marrow–derived stem cells with striated muscle may not be sufficient to activate muscle genes
Authors: Giulio Cossu
Journal: Journal of Clinical Investigation (2004)

Several studies have demonstrated the existence of pluripotent bone marrow–derived stem cells capable of homing to injured cardiac and skeletal muscle; however, there has been little evidence demonstrating the induction of tissue-specific endogenous genes in donor stem cells following engraftment. A new study in this issue reports an intriguing finding that raises additional concerns relating to stem cell plasticity and stem cell therapy in an already heated and controversial field. The study demonstrates that wild-type bone marrow–derived side population stem cells are indeed readily incorporated into both skeletal and cardiac muscle when transplanted into mice that lack δ-sarcoglycan — a model of cardiomyopathy and muscular dystrophy. However, these cells fail to express sarcoglycan and thus to repair the tissue, which suggests that this stem cell population has limited potential for cardiac and skeletal muscle regeneration.
Abstract OT3-2-01: Influence of strength and endurance training on selected physical and psychological parameters and on immune system, metabolism and circulating tumor cells during adjuvant chemotherapy
Authors: C Mundhenke, B Weisser, L Keller, L Sanders, B Summa, J Duerkop, T Schmidt, W Jonat
Journal: Cancer Research (2012)

Abstract Background: Reduced quality of life, limited performance and fatigue are commonly observed side effects of breast cancer systemic treatment. In previous studies sport therapy could improve these symptoms. Sport has also been reported to positively impact the clinical course of the disease. So far it has remained unclear if these influences on clinical outcome are caused by alterations in the immune system or in tumor biology or in glucose or fat metabolism. The aim of this study is to analyse the implications of individual interventions in exercise therapy on endurance, muscle strength, fatigue and quality of life, alterations in the immune system or in tumor biology or in glucose or fat metabolism for breast cancer patients during chemo therapy. Method: The trial is prospectively randomised and controlled and will involve 60 breast cancer patients receiving adjuvant chemotherapy. 20 patients each are randomized into a strength training group, an endurance training group or a control group (with standard care). At the beginning and after 12 weeks the following tests are undertaken: isometric maximum strength test, a PWC 150 test to determine the endurance of patients. The standardised questionnaire EORTC QLQ C30 including module BR23 to measure quality of life and the questionnaire MFI-20 to determine symptoms of fatigue are filled in. Questionnair D2 measures ability to concentrate. Immunologic parameters as CD4, CD8 and T-REG-cells (FACS-Analysis), the number of the circulating tumour cells (measured by density gradient centrifugation) and also the concentration of glucose, insulin, leptin and adiponectin are being measured at study entry and after 12 weeks. Momentarily patients are being screened, recruited and randomised into the trial. The final evaluation of the results is planned II/ 2013. Discussion: The purpose of this study is to show if additional value can be added by individualized strength- or endurance training. Stabilisation or improvement of maximum strength and endurance during chemotherapy, as well as increase of quality of life and reduction of symptoms of fatigue would be a major improvement. Knowledge about effects of physical activity on circulating tumour cells as well as on immunologic alterations and on glucose and fat metabolism under chemotherapy could lead to a more specific counseling of patients and an individualized training program during chemotherapy. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr OT3-2-01.
Recurrence of Variant Angina After Bypass Surgery
Authors: Samuel Vaisrub
Journal: JAMA (1980)

Nothing can be more disconcerting to a patient who has undergone coronary artery bypass surgery than the reappearance of angina. If angina recurs within a year of the operation, it is usually due to closure of a patent graft. If it recurs five to seven years after grafting, the angina is generally attributed to progressive atherosclerotic changes in the native coronary circulation. Less well defined in time and rarely thought of in the context of postsurgical recurrence is Prinzmetal variant angina. Waters and associates<sup>1</sup>observed such recurrences in six patients during a period of 22 months. Although these patients recalled having had angina at rest before bypass grafting, this symptom was usually overshadowed by the more frequent angina experienced during effort and thus ignored. The reappearing angina was diagnosed as Prinzmetal variant on the basis of chest pain occurring at rest and associated with S-T segment elevation on the
Osteoporosis, falls, and age in fracture of the proximal femur.
Authors: C Cooper, D J Barker, J Morris, R S Briggs
Journal: BMJ (1987)

The relative importance of osteoporosis and risk of falling in causing hip fracture is not known. Femoral neck bone mass was measured in 708 elderly people, all of whom had fallen and injured a hip. Below 75 years of age there was a steep increase in relative risk of fracture with reduced bone mass, measured by Singh grade. Above that age the increase in risk was small, and neuromuscular responses which protect the skeleton against trauma may be more important than bone mass.
Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice
Authors: Eileen McGowan, Fiona Pickford, Jungsu Kim, Luisa Onstead, Jason Eriksen, Cindy Yu, Lisa Skipper, M. Paul Murphy, Jenny Beard, Pritam Das, Karen Jansen, Michael DeLucia, Wen-Lang Lin, Georgia Dolios, Rong Wang, Christopher B. Eckman, Dennis W. Dickson, Mike Hutton, John Hardy, Todd Golde
Journal: Neuron (2005)
Should we abandon cervical spine manipulation for mechanical neck pain? Yes
Authors: B. M. Wand, P. J. Heine, N. E. O'Connell
Journal: BMJ (2012)

<b>Benedict Wand and colleagues</b> argue that the risks of cervical spine manipulation are not justified, but <b>David Cassidy and colleagues</b> (doi:10.1136/bmj.e3680) think it is a valuable addition to patient care
A Comparison Study of Blood Glucose Test Strips
Authors: Richard C Worth, Kevin Harrison, John Anderson, Desmond G Johnston, K George M M Alberti
Journal: Diabetes Care (1981)

Blood glucose test strips provide a convenient and rapid method for estimation of blood glucose. They can be read either by eye against a color scale or in a reflectance meter. This study compares the performance characteristics of the principal test strips available. When read visually, the BM Glycemie 20–800 (Chemstrip bG) strip was shown to be more accurate than the Dextrostix strip. Comparison of the meter systems showed Reflotest-Glucose to be more accurate and precise than Dextrostix. This was because the Reflotest system was read closer to the endpoint of color development and because there was less subsequent color fade than with the Dextrostix system. Reflotest-Glucose and Reflotest-Hypoglycemie developed colors that were stable for at least 2 days after completion of the test. However, when using a reflectance meter the Reflotest system required two strips to cover the important range of blood glucose.
Consequences of assessment and intervention among elderly people: a three year randomised controlled trial.
Authors: C Hendriksen, E Lund, E Stromgard
Journal: BMJ (1984)

Over three years 285 randomly selected subjects aged 75 years or more and living in a suburb of Copenhagen were visited every three months in their own homes (the intervention group) to assess whether scheduled medically and socially preventive intervention would influence the number of admissions to hospitals or nursing homes, the number of contacts with general practice, or mortality. A randomly selected group of 287 people of the same age and sex were visited during the final three months of the study (the control group). Two hundred and nineteen admissions to hospitals (4884 bed days) were registered for the intervention group compared with 271 (6442 bed days) for the control group. Especially during the second half of the study, a significant reduction in the number of admissions to hospitals was seen in the intervention group. Twenty people in the intervention group and 29 in the control group moved into nursing homes (p greater than 0.05). The corresponding numbers of deaths were 56 and 75 (p less than 0.05). No difference was seen in the number of contacts with general practice. Significantly fewer emergency medical calls, however, were registered for the intervention group. Subjects in the intervention group benefited from the regular visits and the increased distribution of aids and modifications to their homes to which these led. The regular visits probably also produced an important increase in confidence.
Costs of diabetes in Texas, 1992
Authors: David C Warner, Roy R McCandless, Louis A De Nino, John E Cornell, Jacqueline A Pugh, Genevieve M Marsh
Journal: Diabetes Care (1996)

OBJECTIVE To estimate direct and indirect costs of diabetes in Texas in 1992. RESEARCH DESIGN AND METHODS For most direct medical costs, we relied on third party and provider billing databases, including Medicare, Medicaid, VA facilities, public hospitals, and others. The researchers identified people with diabetes in the respective databases, located all records of their care, and sorted records as clearly, probably, or probably not attributable to diabetes on the basis of principal diagnoses. In most cases, costs were valued as allowable or paid charges. Some medical costs, such as private insurance, were estimated from national data and state surveys. Indirect costs included current short- and long-term disability costs and the discounted present value of future costs of mortality. Disability estimates relied on National Health Interview Survey (NHIS) data and U.S. Department of Labor wage data applied to Texas. Mortality estimates were based on death certificates. RESULTS Total costs clearly or probably attributable to diabetes among Texans in 1992 were estimated at $4.0 billion. Direct medical costs were ∼ $1.6 billion. Indirect costs were estimated at $2.4 billion. the largest direct costs were paid by Medicare. Most indirect costs were from long-term disability. CONCLUSIONS This study demonstrates methods for conducting cost of illness studies at the state level. In a state like Texas, with a large and growing Mexican-American population, estimation of current and future economic costs of diabetes is vital for development of strategies to minimize social and economic consequences of diabetes.
THE EFFECTS OF TESTOSTERONE PROPIONATE IN IMPOTENCE
Authors: HUGH T. CARMICHAEL, WILLIAM J. NOONAN, ALLAN T. KENYON
Journal: American Journal of Psychiatry (1941)

1. Eighteen men who complained of impotence and who had no obvious disease of the central nervous system, no marked structural changes in the genito-urinary tract except for absence of spermatozoa in Case 4, or no manifest deficiency in the internal secretion of the testes, were given intramuscular injections of testosterone propionate in 25 mgm. doses three times or more weekly. 2. In some of our patients psychic and emotional influences played a large part in the production of the impotence. 3. In seven instances relief from the impotence was obtained, while in the eleven other subjects the testosterone propionate did not produce any beneficial effects. 4. In one patient there was a definite reduction in the number of spermatozoa during the course of treatment. 5. It was concluded that the successful results were probably explained by psychological factors, since there was no decrease in potency when sesame oil was substituted and when all injections were stopped. 6. The amount of androgens administered by us was thought to be sufficient to make up for deficiency in testicular secretion. It is, however, desirable to secure experience with larger amounts of the agent. 7. It is our opinion that the depth and degree of neurotic conflicts present in the individual patient may play an important rôle in determining the nature of the results. We suggest that beneficial effects may be observed in those patients in whom neurotic trends are minimal, and who react to such physiological stimulation as testosterone propionate may induce by enough increase in self-confidence to overcome the impotence. We suggest, furthermore, that failure may be noted in those patients who have severe neuroses, and whose conflicts are so enhanced by the physiological stimulation that the anxieties and fears thus aroused lead to still further inhibition of sexual expression. But it should not be forgotten that testosterone propionate may have had no influence whatsoever on sexual excitability, as seems to be the case in normal men, and such benefit as we have observed may be due only to suggestion.
SYSTEMIC MANIFESTATIONS OF SUPPURATIVE DISEASE IN PARANASAL SINUSES
Authors: M. F. ARBUCKLE
Journal: JAMA (1923)

It seems worth while to record the results of some observations of cases in which certain constitutional disorders apparently have been caused by suppurative disease in the paranasal sinuses. The cases to be discussed include those of children and adults. Until recently, there have been only a few physicians who have attached much importance to sinus disease in children because of the generally prevalent idea that in children the sinuses are in such a rudimentary stage of development as to be negligible clinically. The experiences of Dean,<sup>1</sup>Sluder,<sup>2</sup>Lemere<sup>3</sup>and other investigators, as well as my own, have thoroughly convinced me that, in many instances, the portal of entry of many of the more serious ailments of infancy and childhood has been entirely overlooked. Furthermore, I am convinced that a large proportion of cases of chronic nasal disease of adult life, with the attendant constitutional manifestations, have