tbuckley/cabot-search huggingface dataset:
Effect of varying differentiator frequency response on recorded peak dP/dt
Authors: W. H. BARRY, A. M. MARLON, M. ADAMS, D. C. HARRISON
Journal: Cardiovascular Research (1975)

Journal Article Effect of varying differentiator frequency response on recorded peak dP/dt Get access WILLIAM H. BARRY, WILLIAM H. BARRY From the Division of Cardiology, Stanford University School of Medicine, Stanford, California 94305, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar ANTHONY M. MARLON, ANTHONY M. MARLON From the Division of Cardiology, Stanford University School of Medicine, Stanford, California 94305, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar MARSHA ADAMS, MARSHA ADAMS From the Division of Cardiology, Stanford University School of Medicine, Stanford, California 94305, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar DONALD C. HARRISON DONALD C. HARRISON From the Division of Cardiology, Stanford University School of Medicine, Stanford, California 94305, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 9, Issue 3, May 1975, Pages 433–439, https://doi.org/10.1093/cvr/9.3.433 Published: 01 May 1975
Functional Analysis of 11q13.5 Amplicon Identifies <i>Rsf-1</i> (<i>HBXAP</i>) as a Gene Involved in Paclitaxel Resistance in Ovarian Cancer
Authors: Jung Hye Choi, Jim Jinn-Chyuan Sheu, Bin Guan, Natini Jinawath, Paul Markowski, Tian-Li Wang, Ie-Ming Shih
Journal: Cancer Research (2009)

Abstract The chromosome 11q13.5 locus is frequently amplified in several types of human cancer. We have previously shown that 11q13.5 amplification was associated with significantly shorter overall survival in ovarian cancer patients, but the molecular mechanisms of how amplification of this locus contributes to disease aggressiveness remain unclear. Because ovarian cancer mortality is primarily related to resistance of chemotherapeutic agents, we screened the top six candidate genes within this amplicon for their contribution to drug resistance. Rsf-1 (also known as HBXAP) was found to be the only gene in which gene knockdown sensitized tumor cells to paclitaxel. Rsf-1 has been known to interact with hSNF2H to form an ISWI chromatin remodeling complex. We found that Rsf-1 was up-regulated in paclitaxel-resistant ovarian cancer cell lines, and Rsf-1 immunoreactivity in primary ovarian carcinoma tissues correlated with in vitro paclitaxel resistance. Ectopic expression of Rsf-1 significantly enhanced paclitaxel resistance in ovarian cancer cells. Down-regulation of hSNF2H or disruption of hSNF2H and Rsf-1 interaction enhanced paclitaxel sensitivity in tumor cells with Rsf-1 up-regulation. Rsf-1 expression altered expression in several genes and activated certain signaling pathways that may contribute to drug resistance. In conclusion, our results suggest that Rsf-1 is the major gene within the 11q13.5 amplicon that contributes to paclitaxel resistance, and the formation of the Rsf-1/hSNF2H complex is required for inducing this phenotype. [Cancer Res 2009;69(4):1407–15]
Composite end point of graft-versus-host disease-free, relapse-free survival after allogeneic hematopoietic cell transplantation
Authors: Shernan G. Holtan, Todd E. DeFor, Aleksandr Lazaryan, Nelli Bejanyan, Mukta Arora, Claudio G. Brunstein, Bruce R. Blazar, Margaret L. MacMillan, Daniel J. Weisdorf
Journal: Blood (2015)
Effects of intracoronary temperature variation on the coronary circulation
Authors: A. J. LIEDTKE, H. C. HUGHES
Journal: Cardiovascular Research (1974)

Journal Article Effects of intracoronary temperature variation on the coronary circulation Get access A. JAMES LIEDTKE, A. JAMES LIEDTKE From the Cardiooascular Research Section, Departments of Internal Medicine and Comparative Medicine, Pennsylvania State University College of Medicine, M. S. Hershey Medical Center, Hershey, Pennsylvania, 17033, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar HOWARD C. HUGHES HOWARD C. HUGHES From the Cardiooascular Research Section, Departments of Internal Medicine and Comparative Medicine, Pennsylvania State University College of Medicine, M. S. Hershey Medical Center, Hershey, Pennsylvania, 17033, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 8, Issue 6, November 1974, Pages 787–795, https://doi.org/10.1093/cvr/8.6.787 Published: 01 November 1974
Language of self harm is somatic and needs to be learnt
Authors: A. Clark
Journal: BMJ (2002)

EDITOR—In a recent personal view a doctor is exasperated at having to deal with the “bloody overdoses” as a house officer and then becomes one 25 years later.1 A patient who had had depression for 20 years and then harmed herself responded with a poem to staff in accident and emergency departments who think that victims of self harm are a waste of time and resources.2 I was moved by this poem. Self harm is a somatic language. It is a language which uses the body instead of words and feelings. This poem will speak to both victims of self harm and professionals who care for them precisely because it translates the language of self harm.

Staff who care for victims of …
Bradycardia in acute haemorrhage
Authors: Ian Thomas, John Dixon
Journal: BMJ (2004)

We describe three patients who all underwent elective surgery and had acute haemorrhage after the operation. All three patients had hypotension but did not develop the typically associated sign of tachycardia. The assumption that occult bleeding is always associated with tachycardia is incorrect and may lead to a delay in diagnosis.

The accepted and traditional cardiovascular signs of acute blood loss are tachycardia, hypotension, and poor peripheral perfusion. In a healthy adult, tachycardia is a heart rate of more than 100 beats/min. The maximum heart rate a person can sustain is generally accepted to be 220 minus the patient's age. Tachycardia occurs in the initial stage of a biphasic cardiovascular response, which attempts to maintain cardiac output in the face of hypovolaemia and a decreased stroke volume. Neural and hormonal mechanisms mediate this tachycardia after arterial baroreceptors are stimulated. In some patients with acute haemorrhage, however, this initial tachycardic response is absent; this may lead to confusion or a delay in diagnosis. The phenomenon has been called relative bradycardia,1–4 absence of tachycardic response,1–5 or paradoxical bradycardia.6 We describe three patients for whom doctors did not see initial tachycardia during acute haemorrhage.

### Case 1

A 59 year old woman had an elective total abdominal hysterectomy and bilateral salpingo-oophorectomy. Apart from mild asthma, for which she took a ventolin inhaler, she was otherwise fit and well. She was taking no regular drugs. Her preoperative blood pressure was 145/75 mm Hg, pulse rate was 76 beats/min, and haemoglobin concentration was 147 g/l. …
Evidence of Concealed Atrioventricular Conduction in Man
Authors: RICHARD A. CARLETON, JOHN S. GRAETTINGER
Journal: Circulation (1966)

The occurrence of 2:1 A-V block during right atrial pacing in man provided the opportunity to compare A-V conduction time with and without an intervening atrial depolarization at similar ventricular rates. The presence of the interposed atrial depolarization produced prolongation of the subsequent A-V conduction by 0.03 to 0.13 sec, and thus provided evidence of concealed conduction in the normal human heart.
Comparison of Capsule Endoscopy and Enteroscopy with the Double-Balloon Method in Patients with Obscure Bleeding and Polyposis
Authors: T. Matsumoto, M. Esaki, T. Moriyama, S. Nakamura, M. Iida
Journal: Endoscopy (2005)

Background and Study Aims: Video capsule endoscopy and double-balloon enteroscopy (DBE) are novel methods of enteroscopy. The aim of this investigation was to compare the value of CE and DBE in the diagnosis of small-intestinal pathology. Patients and Methods: Thirteen patients with gastrointestinal bleeding of obscure origin and nine patients with known gastrointestinal polyposis were examined using antegrade or retrograde DBE, and the most distal or proximal site in the explored small intestine was marked by submucosal injection of sterilized ink. The patients were then evaluated by CE. Video images obtained by CE were reviewed by an observer who was blinded to the DBE findings. Results: DBE identified positive findings in 12 patients (54.5 %). CE identified positive findings in the area explored by DBE in eight patients (36.4 %), and in the unexplored area in 11 patients (50.0 %). The overall diagnostic yield in the area explored by DBE did not differ between the two procedures. The enteroscopic findings in the area explored by DBE were concordant in 12 of 13 patients with gastrointestinal bleeding of obscure origin. In patients with polyposis, the diagnoses were discordant in three patients, in whom CE failed to detect any polyp. In two of three polyposis patients with concordant positive findings, DBE detected a larger number of polyps than CE did. Conclusions: DBE appears to be superior to CE in the diagnosis of small-intestinal polyps, whereas the value for diagnosing gastrointestinal bleeding of obscure origin is similar in the two procedures.
Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort
Authors: R. A. North, L. M. E. McCowan, G. A. Dekker, L. Poston, E. H. Y. Chan, A. W. Stewart, M. A. Black, R. S. Taylor, J. J. Walker, P. N. Baker, L. C. Kenny
Journal: BMJ (2011)

<b>Objectives</b> To develop a predictive model for pre-eclampsia based on clinical risk factors for nulliparous women and to identify a subgroup at increased risk, in whom specialist referral might be indicated. <b>Design</b> Prospective multicentre cohort. <b>Setting</b> Five centres in Auckland, New Zealand; Adelaide, Australia; Manchester and London, United Kingdom; and Cork, Republic of Ireland. <b>Participants</b> 3572 “healthy” nulliparous women with a singleton pregnancy from a large international study; data on pregnancy outcome were available for 3529 (99%). <b>Main outcome measure</b> Pre-eclampsia defined as ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg, or both, on at least two occasions four hours apart after 20 weeks’ gestation but before the onset of labour, or postpartum, with either proteinuria or any multisystem complication. Preterm pre-eclampsia was defined as women with pre-eclampsia delivered before 37<sup>+0</sup> weeks’ gestation. In the stepwise logistic regression the comparison group was women without pre-eclampsia. <b>Results</b> Of the 3529 women, 186 (5.3%) developed pre-eclampsia, including 47 (1.3%) with preterm pre-eclampsia. Clinical risk factors at 14-16 weeks’ gestation were age, mean arterial blood pressure, body mass index (BMI), family history of pre-eclampsia, family history of coronary heart disease, maternal birth weight, and vaginal bleeding for at least five days. Factors associated with reduced risk were a previous single miscarriage with the same partner, taking at least 12 months to conceive, high intake of fruit, cigarette smoking, and alcohol use in the first trimester. The area under the receiver operating characteristics curve (AUC), under internal validation, was 0.71. Addition of uterine artery Doppler indices did not improve performance (internal validation AUC 0.71). A framework for specialist referral was developed based on a probability of pre-eclampsia generated by the model of at least 15% or an abnormal uterine artery Doppler waveform in a subset of women with single risk factors. Nine per cent of nulliparous women would be referred for a specialist opinion, of whom 21% would develop pre-eclampsia. The relative risk for developing pre-eclampsia and preterm pre-eclampsia in women referred to a specialist compared with standard care was 5.5 and 12.2, respectively. <b>Conclusions</b> The ability to predict pre-eclampsia in healthy nulliparous women using clinical phenotype is modest and requires external validation in other populations. If validated, it could provide a personalised clinical risk profile for nulliparous women to which biomarkers could be added. <b>Trial registration</b> ACTRN12607000551493.
Epidemic Serogroup B Meningococcal Disease in Oregon
Authors: Marion Diermayer, Katrina Hedberg, Frederick Hoesly, Marc Fischer, Bradley Perkins, Michael Reeves, David Fleming
Journal: JAMA (1999)

In 1993, Oregon's incidence of serogroup B meningococcal disease began to rise because of a highly clonal group of strains designated enzyme type 5 (ET-5), the first such increase observed in the United States.To evaluate the impact that the ET-5 strain has had on the epidemiology of meningococcal disease in Oregon.Epidemiologic analysis of surveillance data on Oregon meningococcal disease cases from 1987 through 1996 and multilocus enzyme electrophoresis typing of serogroup B isolates from June 1993 through April 1995 and from April through June 1996.A total of 836 persons with invasive meningococcal disease.Disease frequency and clonality of strains.Serogroup B disease incidence rates more than doubled from the preepidemic period in 1987-1992 (1.0 case per 100000 population) to the recent epidemic period in 1995-1996 (2.2 cases per 100000). The age-specific incidence rate of serogroup B disease among those 15 through 19 years old increased 13-fold between the preepidemic period (0.5 case per 100000) and 1995-1996 (6.4 cases per 100000). However, the proportion of cases with meningococcemia and the case-fatality rate did not change. Of 99 Neisseria meningitidis isolates obtained from 1993-1995, 88 (89%) belonged to the ET-5 complex. Of these, 69 (78%) were a single clone, designated 301. Of 20 serogroup B isolates from 1996, 18 (90%) belonged to the ET-5 complex; 17 (94%) were the 301 clone.Serogroup B meningococcal disease incidence continues at high levels in Oregon with increasing predominance of the ET-5 clonal strains.
Investigation of Family Showing Transmission of a 13-15 Chromosomal Translocation (Denver Classification)
Authors: S. Walker, R. Harris
Journal: BMJ (1962)

Preliminary Communications (Hamerton et al., 1961), and in addition translocation mongols (effectively trisomic) are frequently produced.Although the carriers of the present 13/15 transloca- tion have so far proved to be clinically normal, we are
Keratoderma Palmaris et Plantaris Congenitalis
Authors: D. Macaulay
Journal: BMJ (1951)

LEAD-POISOMNG IN CHILDREN investigations, of which x-ray examination of the long bones is the most important.The possible value of E.E.G. recordings is discussed.Treatment should aim at immobilizing the lead in the bones." De-leading " should never be attempted in children.Lead-poisoning in children could be entirely prevented.Lead paint should never be used in places that children can reach.Lead nipple-shields should be prohibited.The use of dimercaprol in the treatment of lead-poisoning is discussed and is thought to be worthy of trial, especially in cases of lead encephalopathy.Lastly, it is stressed that the diagnosis of pica should always bring with it the question, "Is this child liable to ingest poisons by its habit of dirt-eating ?" Probably the most important of such poisons is lead.We gratefully acknowledge the help of
Tenascin immunoreactivity as a prognostic marker in usual interstitial pneumonia.
Authors: R Kaarteenaho-Wiik, T Tani, R Sormunen, Y Soini, I Virtanen, P Pääkkö
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

In this investigation, tenascin (Tn) expression was studied in 51 cases of different types of fibrotic lung disorders originating for years 1981 to 1995. Our aim was to test if accumulation of Tn at the site of lung injury in usual interstitial pneumonia (UIP) could correlate with the prognosis. Lung biopsies taken from 28 patients with UIP, six with desquamative interstitial pneumonia (DIP), six with sarcoidosis, five with extrinsic allergic bronchioloalveolitis, five with bronchiolitis obliterans organizing pneumonia (BOOP), and one with nonspecific interstitial pneumonia were studied for the expression of Tn by using an immunohistochemical technique. In addition to Tn immunohistochemistry, selected cases were also studied by immunoelectron microscopy and Western blotting. For prognostic studies in UIP the clinical follow-up information was obtained from the patient records. The expression of Tn was increased in each type of fibrosis, especially in UIP. In immunoelectron microscopy the most prominent labeling in UIP was found in association with collagen fibers and within the type 2 pneumocytes. Every studied case of UIP showed reactivity for a polypeptide of M(r) approximately equal to 200,000 by Western blotting. In patients with UIP, increased Tn expression, especially under metaplastic bronchiolar-type epithelium, was associated with a shortened survival time. Immunoelectron microscopic findings support the idea that Tn in UIP is synthesized by the regenerating epithelial rather than interstitial cells in response to pulmonary interstitial inflammation.
Technetium-99m autologous phagocyte scanning: a new imaging technique for inflammatory bowel disease.
Authors: W Pullman, R Hanna, P Sullivan, J A Booth, F Lomas, W F Doe
Journal: BMJ (1986)

<h3>Objective</h3> Patients with Niemann–Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with IBD, but neither the significance nor the functional mechanism of this association is clear. We studied bacterial handling and antibacterial autophagy in patients with NPC1. <h3>Design</h3> We characterised intestinal inflammation in 14 patients with NPC1 who developed IBD. We investigated bacterial handling and cytokine production of NPC1 monocytes or macrophages in vitro and compared NPC1-associated functional defects to those caused by IBD-associated nucleotide-binding oligomerization domain-containing protein 2 (NOD2) variants or mutations in X-linked inhibitor of apoptosis (XIAP). <h3>Results</h3> Patients with the lysosomal lipid storage disorder NPC1 have increased susceptibility to early-onset fistulising colitis with granuloma formation, reminiscent of Crohn9s disease (CD). Mutations in NPC1 cause impaired autophagy due to defective autophagosome function that abolishes NOD2-mediated bacterial handling in vitro similar to variants in NOD2 or XIAP deficiency. In contrast to genetic NOD2 and XIAP variants, NPC1 mutations do not impair NOD2-receptor-interacting kinase 2 (RIPK2)-XIAP-dependent cytokine production. Pharmacological activation of autophagy can rescue bacterial clearance in macrophages in vitro by increasing the autophagic flux and bypassing defects in NPC1. <h3>Conclusions</h3> NPC1 confers increased risk of early-onset severe CD. Our data support the concept that genetic defects at different checkpoints of selective autophagy cause a shared outcome of CD-like immunopathology linking monogenic and polygenic forms of IBD. Muramyl dipeptide-driven cytokine responses and antibacterial autophagy induction are parallel and independent signalling cascades downstream of the NOD2-RIPK2-XIAP complex.
Report of the Scientific Grants Committee
Authors: R. Saundby
Journal: BMJ (1897)

At the meeting in April the Chairman reported that in response to a deputation the President of the Local Govern- ment Board had appointed a very strong Committee on the Aggregation of Children in Pauper Schools, who, after careful investigation extending over eighteen months, had reported in precisely the sense of the resolution of the Parliamentary Bills Committee-that is, that barrack schools ought, as far as possible, to be abolished and replaced by boarding out, and that there should be special arrangements for the children suffering from illness.Mr. Chaplin had only adopted that part of the report which related to sick children, and he proposed, in the first instance, to appoint a special Board to deal with the sick children, which did not go to the root of the evil, and will do little to remove the great evils which arise out of the existing system.A special Association had been formed, under the presidency of Lord Peel, to carry out the whole of the objects as asked for.He had drafted a a statement which recapitulated their demands and stated reasons.The Chairman was authorised to circulate it among members of Parliament, and
In vitro evaluation of forces exerted by a new computer-assisted colonoscope (the NeoGuide Endoscopy System)
Authors: A. Eickhoff, R. Jakobs, A. Kamal, S. Mermash, J. Riemann, J. van Dam
Journal: Endoscopy (2006)

Background: The NeoGuide Endoscopy System (NES) utilizes a fully articulated, computer-controlled insertion tube that allows proximal segments of the colonoscope to follow the path taken by the tip as it is manually advanced through the colon. The system was designed to eliminate looping and scope displacement during colonoscopy. Material and methods: Using in vitro testing, an inanimate flexible model of the colon incorporating four force transducers located at the key flexure points was employed to measure the axial forces on the colon wall during colonoscopy. In the second part of the study, 10 gastroenterologists performed colonoscopies, using a training latex-based simulator, with the NES and with a standard colonoscope. Colonic displacement was independently assessed by six gastroenterologists, with each evaluating endoscopist assigning a score between 0 and 5 corresponding to the maximum colonic displacement observed at any location. Results: The average measured forces (in lbs) at three of the four flexure points were significantly lower (P < 0.05) when the NES was used. The mean colonic displacement was significantly lower for procedures performed with the NES compared with the standard colonoscope (2.36 vs. 4.26, P < 0.001). Interobserver agreement regarding the degree of colonic displacement due to looping was moderate (weighted kappa = 0.45, P < 0.01). Conclusions: Colonoscopy with the NES was associated with significantly less looping and lateral force required for advancement than procedures with a standard colonoscope. The reduced amount of looping suggests that use of the NES in patients might be associated with less discomfort and thus require less sedation.
Incidental Asymptomatic Adrenal Mass Detected by Computed Tomographic Scan
Authors: Laurence D. Wellikson
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Recently, I had such a case as that reported by Prinz et al in the article entitled "Incidental Asymptomatic Adrenal Masses Detected by Computed Tomographic Scanning" (1982;248:701), which further illustrated the need for appreciation of better guidelines for surgery. <h3>Report of a Case.—</h3> A part of a workup for abdominal pain after an auto accident, a 70-year-old woman had a computed tomographic (CT) scan that showed a left adrenal mass. This was confirmed by a subsequent CT scan. The patient had a history of hypertension for several years, but, except for minimal abdominal pain, she was asymptomatic. She specifically had no symptoms related to glucose intolerance, cardiopulmonary disease, vasomotor changes, or postural hypotension. Physical examination was normal, except for a BP of 168/70 mm Hg in a supine position and 150/70 mm Hg while standing without symptoms. Initial laboratory data showed normal cortisol levels and mildly elevated