Calcitonin Deficiency after Radioactive Iodine Treatment
Authors: J. J. Body
Journal: Annals of Internal Medicine (1988)

Brief Reports1 October 1988Calcitonin Deficiency after Radioactive Iodine TreatmentJ. J. Body, MD, N. Demeester-Mirkine, MD, J. Corvilain, MDJ. J. Body, MDSearch for more papers by this author, N. Demeester-Mirkine, MDSearch for more papers by this author, J. Corvilain, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-7-590 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBecause the long-feared carcinogenic and genetic hazards of radioactive iodine (131I) have been refuted (1), many authors now consider this therapy the treatment of choice for patients with toxic multinodular goiter and for most patients with Graves disease. Moreover, the use of ablative doses was recently recommended to correct hyperthyroidism rapidly and to cause hypothyroidism predictably, contrasting with the delayed and unpredictable occurrence of hypothyroidism after conventional131I treatment (2). Intrathyroidal C cells do not trap radioactive iodine but could be damaged indirectly due to their contiguity to follicular cells, as suggested by some reports (3) of an antitumoral effect...References1. GrahamBurman GK. Radioiodine treatment of Graves disease: an assessment of its potential risks. Ann Intern Med. 1986;105:900-5. LinkGoogle Scholar2. Kendall-TaylorKeirRoss PMW. Ablative radioiodine therapy for hyperthroidism: long term follow-up study. Br Med J [Clin Res.] 1984;289:361-3. CrossrefMedlineGoogle Scholar3. NusynowitzPollardBenedettoLecklitnerWare MEAMR. Treatment of medullary carcinoma of the thyroid with I-131. J Nucl Med. 1982;23:143-6. MedlineGoogle Scholar4. BodyHeath JH. Estimates of circulating monomeric calcitonin: physiological studies in normal and thyroidectomized man. J Clin Endocrinol Metab. 1983;57:897-903. CrossrefMedlineGoogle Scholar5. BodyDemeester-MirkineBorkowskiSuciuCorvilain JNASJ. Calcitonin deficiency in primary hypothyroidism. J Clin Endocrinol Metab. 1986;62:700-3. CrossrefMedlineGoogle Scholar6. RefetoffDemeester-MirkineErmansDeGroot SNAL. Rapid control of thyrotoxicosis with combined 131I, antithyroid drugs and KI therapy. J Nucl Med Allied Sci. 1977;21:23-9. MedlineGoogle Scholar7. TiegsBodyBartaHeath RJJH. Secretion and metabolism of monomeric human calcitonin: effects of age, sex and thyroid damage. J Bone Miner Res. 1986;1:339-49. CrossrefMedlineGoogle Scholar8. ThurstonWilliams VE The effect of radiation on thyroid C cells. Acta Endocrinol. 1982;99:72-8. CrossrefMedlineGoogle Scholar9. AustinHeath LH. Calcitonin: physiology and pathophysiology. N Engl J Med. 1981;304:269-78. CrossrefMedlineGoogle Scholar10. CoindreDavidRiviere JJL. Bone loss in hypothyroidism with hormone replacement: a histomorphometric study. Arch Intern Med. 1986;146:48-53. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. J. Body, MD; N. Demeester-Mirkine, MD; J. Corvilain, MDAffiliations: From Institut Jules Bordet and Hôpital Universitaire Brugmann, Bruxelles, Belgium. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRadioactive iodineDeterministic Effects of RadiationRadioactive iodine treatment in medullary thyroid carcinomaCalcitonin Reserve in Different Stages of Atrophic Autoimmune ThyroiditisBone Disease in HyperthyroidismHyperthyroidism, Thyroid Hormone Therapy, and BoneEffect of 131 I treatment on the calcitonin response to calcium infusion in hyperthyroid patientsPostsurgical Follow-Up and ManagementIodine-131 treatment of hyperthyroidism: current issuesBone mineral density in postmenopausal women treated with L-thyroxineBone mineral density in postmenopausal women treated with L-thyroxineThyroid hormones, iodine and antithyroid drugsTHE EFFECT OF RADIOACTIVE IODINE TREATMENT ON THYROID C CELLSThyroid hormones, iodine and antithyroid drugs 1 October 1988Volume 109, Issue 7Page: 590-591KeywordsCalcitoninCellsGenetic diseasesHyperthyroidismHypothyroidism ePublished: 1 December 2008 Issue Published: 1 October 1988 PDF downloadLoading ...