The Treatment of Staphylococcal Infection with Nafcillin with a Discussion of Staphylococcal Nephritis
Authors: BRUCE C. NYDAHL
Journal: Annals of Internal Medicine (1965)

Article1 July 1965The Treatment of Staphylococcal Infection with Nafcillin with a Discussion of Staphylococcal NephritisBRUCE C. NYDAHL, M.D., WENDELL H. HALL, M.D., F.A.C.P.BRUCE C. NYDAHL, M.D.Search for more papers by this author, WENDELL H. HALL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-1-27 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNafcillin (UNIPEN®) is one of the new penicillinase-resistant semisynthetic penicillins. It can be administered orally or parenterally. In vitro studies have shown it to have high activity against penicillinase-producing staphylococci and other gram-positive cocci, although less than penicillin G against the latter group. Clinical reports on nafcillin have dealt largely with absorption, excretion, and distribution of the drug (1-5) and staphylococcal integumentary infections. A summary of our total experience with nafcillin in 50 cases will be presented. During this study several aspects of staphylococcal disease impressed us as warranting comment, particularly the renal complications. The following cases are reported in...References1. KLEINFINLAND JOM: Nafcillin: antibacterial action in vitro and absorption and excretion in normal young men. Amer. J. Med. Sci. 246: 10, 1963. CrossrefMedlineGoogle Scholar2. SIDELLBURDICKBRODIEBULGERKIRBY SREJRJWM: New antistaphylococcal antibiotics. Arch. Intern. Med. (Chicago) 112: 21, 1963. CrossrefMedlineGoogle Scholar3. WALKENSTEINWISERLEBOUTILLIERGUNDMUNDSENKIMMEL SSRECH: Absorption, metabolism, and excretion of the semisynthetic penicillin 6-(2-ethoxyl-1-naphthamido) penicillanic acid (nafcillin). J. Pharm. Sci. 52: 763, 1963. CrossrefMedlineGoogle Scholar4. 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Author, Article, and Disclosure InformationAuthors: BRUCE C. NYDAHL, M.D.; WENDELL H. HALL, M.D., F.A.C.P.Affiliations: Minneapolis, MinnesotaFrom the Veterans Administration Hospital, and the Department of Medicine, University of Minnesota Medical School, Minneapolis, Minn.This work was supported by a grant from Wyeth Laboratories, Philadelphia, Pa.Requests for reprints should be addressed to Wendell H. Hall, M.D., Medical Service, Veterans Administration Hospital, Minneapolis, Minn. 55417. 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EDWARD MACMAHON, M.D., LOUIS WEINSTEIN, PH.D., M.D., F.A.C.P.Biopharmaceutical Considerations in Subcutaneous and Intramuscular Drug AdministrationNewer PenicillinsInfective Endocarditis in the Antibiotic Era 1 July 1965Volume 63, Issue 1Page: 27-43KeywordsDrug absorptionDrug distributionDrugsExcretionHospital medicineNephritisPenicillinRenal diseasesSepsisStaphylococcal infection ePublished: 1 December 2008 Issue Published: 1 July 1965 PDF downloadLoading ...