tbuckley/cabot-search huggingface dataset:
Re: Francesco Porpiglia, Carlo Terrone, Julien Renard, Sussana Grande, Francesca Musso, Marco Cossu, Francesca Vacca and Roberto Mario Scarpa. Transcapsular Adenomectomy (Millin): A Comparative Study, Extraperitoneal Laparoscopy Versus Open Surgery. Eur Urol 2006;49:120–6
Authors: Endre Zoltan Neulander
Journal: European Urology (2006)
Cancer Risks for Male Carriers of Germline Mutations in <i>BRCA1</i> or <i>BRCA2</i>: A Review of the Literature
Authors: Alexander Liede, Beth Y. Karlan, Steven A. Narod
Journal: Journal of Clinical Oncology (2004)

Major risks conferred by BRCA1 and BRCA2 in women are for cancers of the breast, ovary, fallopian tube, and peritoneum. Male carriers of mutations in BRCA1 or BRCA2 are also susceptible to cancer; however, their risks remain poorly understood and their optimal clinical management has not yet been defined. This article reviews studies that estimate risk associated with mutations in BRCA1 or BRCA2, with a focus on the cancer sites most relevant to men. Male BRCA1 mutation carriers are at increased risk of cancers of the prostate and breast. Evidence supporting increased susceptibility to colon cancer is limited. In contrast to women, who have a greater lifetime risk of cancer with mutations of the BRCA1 gene, BRCA2 is the more important gene for men. The spectrum of cancers is wide for BRCA2 and some studies report that the overall cancer risk for male BRCA2 carriers exceeds the risk for female carriers. In particular, the relative risk to male BRCA2 mutation carriers is high before age 65 years, largely attributable to breast, prostate, and pancreatic cancers. BRCA2 mutation carriers are also at risk of stomach cancer and melanoma (of the skin and eye). Additional research into risks to male BRCA1 or BRCA2 mutation carriers is necessary, specifically to determine the magnitude of excess cancer risk among BRCA2 carriers and to increase our understanding of the basis for the observed site-specificity in cancer development.
Pattern of carbon dioxide stimulated breathing in patients with chronic airway obstruction.
Authors: C S Garrard, D J Lane
Journal: Thorax (1981)

The pattern of stimulated breathing during carbon dioxide inhalation was studied in a group of 21 patients with severe irreversible airways obstruction (mean FEV1 = 0.9 litre, mean FEV1/FVC% = 50%). Carbon dioxide rebreathing experiments were performed, the ventilatory response being defined in terms of total ventilation (V) and CO2 sensitivity (S). Breathing pattern was defined by the changes in tidal volume (delta VT) and respiratory frequency (delta f) and the maximum VT achieved (VTmax). Contrary to some previous studied no significant relationship could be demonstrated between the severity of airway obstruction (FEV1/FVC%, Raw) and the ventilatory response to rebreathing (V, S, delta VT, delta f, VTmax). However, measurements of dynamic lung volume (FEV1, FVC, IC) were found to be significantly correlated with the breathing pattern variables (delta VT, delta f, VTmax). Resting PaO2 and PaCO2 were significantly correlated with delta VT but not delta f. Results indicate that the degree of airway obstruction does not dictate the ventilatory or breathing pattern response to carbon dioxide induced hyperpnoea. In contrast it is the restriction of dynamic lung volume, by limiting the VT response, that appears to determine the ventilatory and breathing pattern response in patients with severe airway obstruction.
Granulocyte migration in vivo and in vitro in healthy children of parents with atopic asthma
Authors: R. Matusiewicz, K. Rusiecka‐Matisiewicz
Journal: Allergy (1987)

Healthy children of atopically asthmatic parents received in vivo and in vitro granulocyte migration tests. Eleven children whose parents were both asthmatic showed statistically significant inhibition of granulocyte migration compared with controls.
The Pattern of Health Organization in Canada
Authors: Alex. Mair, G. H. M. Hatcher
Journal: BMJ (1957)

logical Medicine of the University of Mysore, and in 1956 13 were admitted to the two-year course.This Institute is broad in its concept and ambitious in its aims, which cover not only negative aspects of mental health but as Rajkumari Amrit Kaur, formerly Minister of Health in India, has stated: "The positive aspect, namely, that of training the normal man of average mental calibre to gain control over his emotional equipment and intellectual power so as to promote the growth of an integrated personality."The task is large but is being tackled with so much enthusiasm that it is inconceivable that what is accomplished can be less than important.In addition to these institutes, there is one for leprosy, and there are the Indian Cancer Research Centre, a Virus Research Centre at Poona, an Institute for Drug Research at Lucknow, and it is proposed to set up institutes of biology and for research into occupational health.Mention of the Institute for Drug Research brings to mind the demands which have been voiced by many sections of the Indian people for a revival of the indigenous systems of medicinethe Ayurvedic and the Unani-and of homoeopathy.The Government of India has appointed committees to study and report on these systems, and research aimed at assessing their various merits is in progress.Current opinion and pronouncements from leading Indian politicians indicate that it is unlikely that India will reject modern scientific medicine on any significant scale to return to the older.systems and the whole pattern of recent medical developments supports such a view.Nevertheless, investigations are proceeding to determine to what extent indigenous systems can be developed and regulated for medical relief in the country, and in the interests of humanity it is to be hoped that in this as in all medical matters politicians and admin- istrators can be constrained to accept facts instead of expressing and attempting to legislate on the basis of their personal opinions.Among the institutes, as in the case of the medical colleges, those which have been long established continue to serve, and to serve well, the people of India and medical science generally.At Conoor, South India, the Nutrition Research Institute, originally founded by Sir Robert McCarrison, continues with 'an output of first-class work which will compare favourably with that from any similar institute in the world.The All-India Institute of Hygiene and Public Health, Calcutta, was established in 1933 and aims at the provision of first-class advanced instruction in the methods of preventive and social medicine, suited to India's peculiar problems.Its large staff includes eight professors.
Pegylated interferon-α, ribavirin, and rituximab combined therapy of hepatitis C virus–related mixed cryoglobulinemia: a long-term study
Authors: Franco Dammacco, Felicia Anna Tucci, Gianfranco Lauletta, Pietro Gatti, Valli De Re, Vincenza Conteduca, Silvia Sansonno, Sabino Russi, Maria Addolorata Mariggiò, Maria Chironna, Domenico Sansonno
Journal: Blood (2010)
Academic Freedom in Clinical Research
Authors: David G Nathan, David J Weatherall
Journal: New England Journal of Medicine (2002)

“Is the university–industrial complex out of control?” The editorial that appeared under this eye-catching title in Nature in January 2001 came to the conclusion that links between academia and industry are of increasing concern to academics and to society at large and that the sectors involved must review and revise their policies in order to sustain the public accountability and academic freedom of universities.1 It ended with a list of New Year's resolutions for actions that would be required to maintain public trust in higher education and publicly funded research. But with the notable exception of the decision of many . . .
Results of retransplantation for recurrent hepatitis C
Authors: Sasan Roayaie, Thomas D. Schiano, Swan N. Thung, Sukru H. Emre, Thomas M. Fishbein, Charles M. Miller, Myron E. Schwartz
Journal: Hepatology (2003)

Retransplantation for recurrent hepatitis C virus (HCV) has been evaluated in small series. In this study, patients undergoing transplantation for HCV-related cirrhosis with subsequent retransplantation more than 90 days for recurrent HCV (proven by pathologic examination of the explant and exclusion of other factors) were prospectively followed. This group was compared with a simultaneous cohort without HCV infection undergoing retransplantation more than 90 days after primary transplantation. Forty-two patients underwent retransplantation for recurrent HCV with a median survival of 12.9 +/- 6.7 months after retransplantation. Twenty patients (48%) were dead at 6 months, and 13 (65%) of these deaths were due to sepsis. On univariate analysis, creatinine level greater than or equal to 3 mg/dL, platelet count less than 100000/microL, prothrombin time (PT) greater than or equal to 16 seconds, alkaline phosphatase level less than or equal to 240 U/L, gamma-glutamyltransferase level less than or equal to 130 U/L, and donor age of 60 years or greater all correlated significantly with shorter survival after retransplantation. PT and donor age were predictors of survival on multivariate analysis. Patients undergoing retransplantation for recurrent HCV had a significantly shorter median survival than the 55 patients undergoing retransplantation for other chronic reasons of graft loss (75.6 +/- 17.7 months). In conclusion, median survival after liver retransplantation for recurrent HCV is significantly shorter than after retransplantation for other causes of late graft loss. Most deaths occur in the first 6 months and are due to sepsis. Candidates for retransplantation with a preoperative PT less than 16 seconds and those receiving grafts from donors younger than 60 years can expect a significantly longer median survival after retransplantation.
Improvement of Natural Knowledge — The Osler Club of London
Authors: John Lister
Journal: New England Journal of Medicine (1960)

THE tercentenary of the foundation of the Royal Society was commemorated in July by a program of celebrations that were formally opened by the Queen. The British Medical Journal published a series of articles describing the prominent role of physicians throughout the history of the Society, and, in a special number, the Times described the foundation and aims of the Society and the diversity of scientific interest covered by past and present fellows.Although it was in November, 1660, that the Royal Society may be said to have been founded, a group of scientific men had been meeting in London . . .
Does Diagnosing Fatty Liver and Chronic Kidney Disease Do More Good Than Harm?
Authors: Druin Burch
Journal: PLoS Medicine (2014)

In this week’s issue of PLOS Medicine, Musso and colleagues report that two conditions, both occupying increasing amounts of medical attention, may be linked [1]. Their paper demonstrates that non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD) even after adjustment for major shared risk factors. ‘‘Future research,’’ they write, ‘‘should evaluate strategies and interventions to prevent renal disease
Expression of the Progestin-Induced Fatty Acid Synthetase in Benign Mastopathies and Breast Cancer as Measured by RNA In Situ Hybridization
Authors: D. Chalbos, C. Escot, C. Joyeux, M.-J. Tissot-Carayon, A. Pages, H. Rochefort
Journal: JNCI Journal of the National Cancer Institute (1990)

We have shown previously that fatty acid synthetase (FAS) is specifically induced by progestins in human breast cancer cell lines. To test the potential value of FAS as a clinical marker in breast diseases, we measured FAS expression in frozen sections of 22 benign and 27 malignant mammary tumors using in situ hybridization with the [ 35 S]UTP αS-labeled FAS anti-sense mRNA. The hybridized RNA was quantified with an IMSTAR computerized image analyzer. We found FAS RNA in epithelial cells, but no labeling was detected in the connective tissue. In breast cancer, we found no correlation between FAS expression and estrogen receptor and progesterone receptor concentrations or status. However, the level of FAS was significantly (P <.02) higher in premenopausal than in post-menopausal patients and increased with the grade of tumor differentiation (P <.005 between the poorly and well-differentiated tumors). In benign mastopathies, high levels of FAS RNA were found in some cysts (mostly with apo-crine metaplasia). In lobules, the FAS RNA level increased proportionally to the degree of proliferation determined by histological examination (P <.015) and correlated with the H4 histone level measured in an adjacent section using insitu hybridization (r = 0.85, P <.001). In ductal structures, a lower correlation (r = 0.64, P <.01) was found between FAS and H4 RNA levels. We conclude that FAS RNA is overexpressed in some mammary tumors and may be useful in predicting high-risk mastopathies and less aggressive breast cancers. [J Natl Cancer Inst 82:602–606, 1990]
Outcome of living unrelated (commercial) renal transplantation
Authors: Mehmet Şükrü Sever, Rümeyza Kazancioğlu, Alaattin Yildiz, Aydin Türkmen, Tevfik Ecder, S. Mehmet Kayacan, Vedat Çelik, Sevgi Şahin, A. Emin Aydin, Uluğ Eldegez, Ergin Ark
Journal: Kidney International (2001)
Malignant melanoma: how error amplification by screening creates spurious disease
Authors: S. Shuster
Journal: British Journal of Dermatology (2009)

The increased incidence of melanoma with little or no change in mortality has been attributed to the histopathological reclassification of benign disease as malignant, the consequence of diagnostic drift. An entirely new, additional explanation has now been found, and is defined as error amplification by screening. This previously unrecognized artefact is shown to be an inevitable consequence of the uneven operation of routine histopathological error in the diagnosis of borderline malignancy; thus, as the equality of diagnostic plus/minus is lost, it is no longer self‐correcting, and the overdiagnosis of malignancy therefore outweighs its underdiagnosis: the error is then amplified by patient screening. The magnitude of this new artefact is a function of the reproducibility of routine histopathological diagnosis and the number of patients screened, and the evidence on this, and from studies done for other purposes, shows the error to be considerable. The artefact of error amplification by screening detracts from a possible role for ultraviolet radiation in the increase in melanoma incidence and provides an explanation of their erroneous association; in addition to melanoma, it could be a major source of misdiagnosis of other cancers associated with patient screening programmes.
Maxwell Stanley Sewell
Authors: H. Sewell
Journal: BMJ (2008)

Maxwell Sewell, a north London general practitioner since the early 1960s who ran the surgery at 103 Crouch Hill, Crouch End, was admired and respected by patients and colleagues. Since his retirement in 1999, former patients still ask after him with fondness, and practice staff and other medical colleagues say they miss his warm, friendly, and smiling personality.

Maxwell obtained a full scholarship to study medicine at Leeds University Medical School, from where he qualified MB …
Evaluation of Ibuprofen (Motrin)
Authors: John R. Lewis
Journal: JAMA (1975)

Ibuprofen is a new, mild analgesic agent that may be useful in the symptomatic treatment of rheumatoid arthritis and osteoarthritis. Results of clinical studies have shown that its beneficial effects in these conditions are comparable, but not superior, to those of aspirin. However, at recommended doses it has less anti-inflammatory effect than aspirin. Its usefulness as an analgesic in the treatment of other types of pain and as an antipyretic has not yet been established. Ibuprofen causes fewer adverse effects on the gastrointestinal system, including occult bleeding, than aspirin. Serious adverse reactions have not been reported. Thus, ibuprofen may be acceptable for use in patients who cannot tolerate aspirin or other antirheumatic drugs. (<i>JAMA</i>233:364-365, 1975)
Interpretation of Bone Scans
Authors: Donald E. Butler
Journal: JAMA (1974)

An informal survey of nonacademic nuclear medicine laboratories indicates that about three fourths do bone scans; most do only a few, but some do more than 50 a month. Approximately 800,000 were done in 1973. The indications for the procedure are simple. The patient has cancer, primarily of the breast, prostate gland, or lung, or has recently developed pain seemingly localized to bone. The choice of therapy hinges on the presence and extent of metastases to bone. The interpretation of the scan is usually simple. It is read as "within normal limits," or it is equivocal for various reasons, or it shows one or more regions of definite osteoblastic activity. A few laboratories report 75% of their scans as "normal." Some report almost no "normals." The frequent occurrence of a "normal" bone roentgenogram with an "abnormal" bone scan, and the less frequent "abnormal" roentgenogram with "normal" scan causes confusion among
Process of healing of mucosal defects in the esophagus after endoscopic mucosal resection: histological evaluation in a dog model
Authors: M. Honda, T. Nakamura, Y. Hori, Y. Shionoya, A. Nakada, T. Sato, K. Yamamoto, T. Kobayashi, H. Shimada, N. Kida, A. Hashimoto, Y. Hashimoto
Journal: Endoscopy (2010)

See also: Commentaire de travail de M. Honda et al., pp. 1092Endoscopy 2010; 42(12): 1121-1121DOI: 10.1055/s-0032-1306717
A Female Pioneer—Doubly Recognized
Authors: Walter H. C. Burgdorf, Leonard J. Hoenig
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
What Are the Patient’s Wishes?
Authors: Joshua Feblowitz, Jeremy Richards
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Cardiac-Allograft Vasculopathy
Authors: Robin K. Avery
Journal: New England Journal of Medicine (2003)

Vasculopathy of cardiac allografts is a major therapeutic challenge, occurring in 50 percent or more of heart-transplant recipients in the first several years after surgery. Improving survival for these patients will require the use of new strategies to prevent this relentlessly progressive complication. Allograft vasculopathy involves diffuse narrowing and occlusion of the coronary arteries, rather than the more focal lesions of conventional atherosclerosis (see Figure).1 The addition of intravascular ultrasonography to standard coronary angiography increases the sensitivity of the procedure for diagnosis and provides a concentric view of the vessel under study.Events during the first year after transplantation appear . . .
Effects of nifedipine on intrinsic myocardial stiffness in man.
Authors: P B Kurnik, M R Courtois, P A Ludbrook
Journal: Circulation (1986)

To determine whether alteration of intrinsic myocardial stiffness is responsible for the reduction of left ventricular filling pressure and volume by nifedipine in patients with impaired baseline ventricular function, we evaluated the hemodynamic responses in 32 patients undergoing diagnostic cardiac catheterization. Micromanometric pressure and ventriculographic dimensional data were acquired before and 30 min after randomly assigned administration of nifedipine (20 mg sublingual) or placebo. A mathematical model requiring no assumptions about the stress-radius relationship or direct measurement of strain was used. No hemodynamic variables were changed after placebo. Left ventricular end-diastolic volume and pressure declined and cardiac output increased after nifedipine, particularly in subjects with impaired ventricular performance. Despite these salutary effects, intrinsic myocardial stiffness, elastic stiffness at a common level of stress, chamber stiffness, and rate of isovolumic relaxation were unchanged after nifedipine, even in patients with abnormal baseline ventricular function. The potent peripheral arteriodilator effect of nifedipine, rather than any direct myocardial or ventricular effects, appears to be responsible for the improved systolic and diastolic performance.
Abnormal Matrix Recognition By Morris Hepatomas Correlates with Low Glucagon Binding Capacity
Authors: Marisabel Mourelle, Javier Cordero-Hernández, Patricia Ponce-Noyola, Marcos Rojkind
Journal: Hepatology (1983)

Liver biomatrix contains a group of connective tissue components needed for attachment, survival, and maintenance of liver-specific functions of adult rat hepatocytes in culture. An acidic extract of liver biomatrix that contains a group of glycoproteins can replace intact biomatrix in promoting attachment and survival of hepatocytes. However, except for albumin synthesis, liver-specific functions have not been tested. Acidic extracts of biomatrices prepared from heart, kidney, lung, and spleen (heterologous) contain a similar group of glycoproteins, but differ with respect to liver glycoproteins in their capacity to sustain hepatocyte binding. Normal hepatocytes attach poorly to heterologous glycoprotein extracts, although regenerating and tumoral hepatocytes attach to liver glycoproteins and adhere equally well or with greater efficiency to heterologous glycoprotein extracts. The increased efficiency of hepatocytes to attach to kidney biomatrix-derived glycoproteins showed a linear correlation with the decreased glucagon binding capacity of their isolated plasma membranes. An epithelioid cell-line derived from kidney (MDCK) attached with higher efficiency to kidney than to liver glycoproteins. These results suggest that biomatrices may contain specific glycoproteins needed for attachment and survival of their epithelial cells. This specificity is lost during the proliferative state of regenerating and tumoral hepatocytes and could be important in the general mechanism of tumor dissemination and metastases.