tbuckley/cabot-search huggingface dataset:
Staging of carcinoma of the pancreas.
Authors: J E Trapnell
Journal: BMJ (1979)

Retroperitoneal fibrosis after treatment with atenolol SIR,-The report from Belfast City Hospital (23-30 December, p 1786) implying that atenolol may have been the cause of retroperitoneal fibrosis in a 68-year-old woman deserves comment.There are several reasons for supposing that the suspicion of a cause- and-effect relationship is not well founded.The authors state that this case was reported "because of the established relationship between the earlier beta-blocker practolol and similar types of sclerosing fibroblastic reaction."However, in more than 200 cases of
The Crucial Link between Literacy and Health
Authors: David A. Nardone
Journal: Annals of Internal Medicine (2004)

Letters6 July 2004The Crucial Link between Literacy and HealthDavid A. Nardone, MDDavid A. Nardone, MDFrom Hillsboro, OR 97124.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-1-200407060-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read the article by Jennifer Fisher Wilson on the link between literacy and health (1) with interest and found it very useful. I offer 4 complementary strategies that physicians can use to offset problems with patient literacy.First, encourage patients to bring a family member or advocate to the visit. Advocates can facilitate dialogue and thereby understanding between patients and physicians. In my 35 years of clinical practice, rarely has a patient objected to the presence of a third party.Second, devote a segment of each visit to reviewing the patient's active medication list. I have ...Reference1. Wilson JF. The crucial link between literacy and health. Ann Intern Med. 2003;139:875-8. [PMID: 14623636] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: David A. Nardone, MDAffiliations: From Hillsboro, OR 97124. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Crucial Link between Literacy and Health Jennifer Fisher Wilson Metrics Cited byThe relationship between health literacy and quality of life among frequent users of health care services: a cross-sectional study 6 July 2004Volume 141, Issue 1 Page: 81 Keywords Blood pressure Heart Ischemia Literacy Patient advocacy Visual impairments ePublished: 6 July 2004 Issue Published: 6 July 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Egypt sees U turn on female circumcision
Authors: P. Kandela
Journal: BMJ (1995)

Campaigners for a ban on female circumcision have been shocked by the way in which, they claim, the Egyptian government has now backtracked on the issue. After President Hosni Mubarak promised to introduce legislation to stop the operation the health minister, Dr Ali Abdul Fatah Omaar, has now declared: “We have no plans to ban this operation by introducing legislation, but we are looking at ways for it to be carried out by qualified doctors and under proper medical supervision.” He made this statement after he emerged from a meeting with Sheikh Jad El Haq of Al Azhar, who is against any ban on the operation.

The issue came to prominence last September, when the CNN …
Insulin’s effect on glucose production: direct or indirect?
Authors: Eugene J. Barrett
Journal: Journal of Clinical Investigation (2003)

Insulin’s effects on glucose homeostasis have been studied as extensively as any area of metabolic regulation. It is therefore particularly exciting when new technologies allow a fresh look at older, well-studied but unresolved issues. This excitement is heightened when information from new approaches challenges accepted paradigms. Recent studies have proved that tissue-specific knockout mice provide such an approach. For example, tissue-specific deletion of the insulin receptor in skeletal muscle yields a mouse (the muscle-specific insulin receptor knockout or MIRKO) with a smaller musculature but with normal fasting and postchallenge glucose and insulin concentrations (1). This was quite unexpected inasmuch as physiologic studies in humans had indicated that greater than 80% of insulin-mediated glucose disposal occurred in skeletal muscle. Why then, despite severe skeletal muscle insulin-resistance, was overall body glucose homeostasis not impaired? Recognizing that developmental compensation for the absence of insulin receptors in muscles might have occurred, investigators examined downstream signaling molecules of the insulin receptor pathway as well as the amount of IGF-1 receptor in muscle. No compensatory processes were identified. By default they concluded that tissues other than muscle, at least in the mouse, were more important in the maintenance of normal glucose metabolism. Interestingly, selective disruption of the Glut-4 transporter in muscle produced insulin resistance as well as glucose intolerance in some mice. Again however, this did not have as profound metabolic consequences as might be expected (2). Notably, deletion of Glut-4 in adipose also produced insulin resistance in muscle (and liver), however the mechanism for these secondary effects has not been defined (3).
Tetraiodothyroacetic acid-tagged liposomes for enhanced delivery of anticancer drug to tumor tissue via integrin receptor
Authors: Sangbin Lee, Jiyeon Kim, Gayong Shim, Sunil Kim, Su Eun Han, Kwangmeyung Kim, Ick Chan Kwon, Yongseok Choi, Young Bong Kim, Chan-Wha Kim, Yu-Kyoung Oh
Journal: Journal of Controlled Release (2012)
Eosinophilic Inflammation Is Prominent In Food Protein-induced Enterocolits Syndrome, Multi-center Case-series Study.
Authors: I. Nomura, T. Fukuie, Y. Ohya, A. Terada, S. Hosokawa, N. Ohtsuka, H. Hoshina, M. Watanabe, A. Isozaki, N. Ito
Journal: Journal of Allergy and Clinical Immunology (2009)
TCTAP C-174 Successful Treatment of a Pericardial Hemangioma with a Stent Graft
Authors: Chiate Liao, Jhih-Yen Shih, Jinn-Ming Chang, Wan-Ling Miriam Wu, Wen-Shiann Wu, Zhih-Cheng Chen
Journal: Journal of the American College of Cardiology (2014)
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration
Authors: Patrick Weydt, Victor V. Pineda, Anne E. Torrence, Randell T. Libby, Terrence F. Satterfield, Eduardo R. Lazarowski, Merle L. Gilbert, Gregory J. Morton, Theodor K. Bammler, Andrew D. Strand, Libin Cui, Richard P. Beyer, Courtney N. Easley, Annette C. Smith, Dimitri Krainc, Serge Luquet, Ian R. Sweet, Michael W. Schwartz, Albert R. La Spada
Journal: Cell Metabolism (2006)
Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia
Authors: Medhat Shehata, Susanne Schnabl, Dita Demirtas, Martin Hilgarth, Rainer Hubmann, Elena Ponath, Sigrun Badrnya, Claudia Lehner, Andrea Hoelbl, Markus Duechler, Alexander Gaiger, Christoph Zielinski, Josef D. Schwarzmeier, Ulrich Jaeger
Journal: Blood (2010)
Abetalipoproteinemia: Rarity and Relevance
Authors: Robert K. Ockner
Journal: New England Journal of Medicine (1971)

At the time (1950) when Bassen and Kornzweig first described two patients with bizarre abnormalities in the nervous system and red blood cells,1 any suggestion that this syndrome would in two decades be related to a defect involving one of several as yet undiscovered lipid-transporting peptides might well have been written off as lunacy. After all, understanding of the lipoproteins themselves was still in its infancy, and most of the concepts and technics that subsequently proved to be instrumental in the development of this understanding were either unborn or not yet conceived. However, in 1960, the absence of beta lipoproteins . . .
The Effect of Full-Time Faculty Hospitalists on the Efficiency of Care at a Community Teaching Hospital
Authors: Herbert S. Diamond
Journal: Annals of Internal Medicine (1998)

Background: Hospitalists are increasingly being used for inpatient care. Objective: To investigate whether the use of hospitalists is beneficial. Design: Retrospective cohort study. Setting: Inpatient medical service of a 500-bed community teaching hospital. Participants: 1620 patients in the study group, seen during the hospitalist year; 1679 patients from the same outpatient practice as the study group, seen during the previous year (prehospitalist year); an unselected comparison group of 3413 patients seen during the prehospitalist year and 3223 patients seen during the hospitalist year; and a subset of the unselected comparison group, cared for by outpatient practices, who had a prehospitalist length of stay similar to that of the study group (743 patients in the prehospitalist year and 786 in the hospitalist year). Interventions: Full-time faculty hospitalists cared for the study group, were in the hospital during normal working hours, and made decisions throughout the day. In the prehospitalist year and in the comparison groups, primary care physicians managed their own hospitalized patients. Measurements: Length of stay; cost of care; costs of hematology and chemistry evaluation, pharmacy, and radiology; and readmissions were determined for the prehospitalist and hospitalist years. Results: In the study group, median length of stay decreased from 6.01 to 5.01 days (P < 0.001). Median cost of care decreased from $4139 to $3552 (P < 0.001), and the 14-day readmission rate decreased from 9.9 to 4.64 readmissions per 100 admissions (P < 0.001). In the comparison groups, length of stay decreased but both cost of care and readmission rates increased. Conclusion: Hospitalists may improve the efficiency of inpatient care. Further study in various settings is needed to verify these findings.
Antacids and Anticholinergic Drugs
Authors: ARMAND LITTMAN
Journal: Annals of Internal Medicine (1975)

Controlled clinical trials have provided some useful evidence of the effectiveness or lack of effectiveness of antacids and anticholinergic drugs. However, few such trials are free of serious methodologic or clinical criticism, and the use of these agents cannot be defined with any degree of scientific certainty. Their principal uses still focus on reduction of gastric acid content, and their best use requires individualization for each patient. With anticholinergic drugs there is little if any pharmacologic effect without some side-effects, and dose adjustment may be more important than the choice among the many drugs considered effective. Some new antacids offer better neutralization than old ones, but are at least as likely to affect colonic function. Although toxicity, side-effects, and interactions with other drugs are minimal, they should be watched for.
I-J restrictions on the activation and interaction of parental and F1-derived TS3 suppressor cells.
Authors: M Minami, S Furusawa, M E Dorf
Journal: The Journal of Experimental Medicine (1982)

An experimental system was developed to independently analyze the H-2 and Igh genetic restrictions at two steps of the 4-hydroxy-3-nitrophenylacetyl hapten (NP) suppressor cell pathway. This experimental system allowed genetic analysis of the activation of TS3 cells by hybridoma-derived TsF2 and independent analysis of the genetic restrictions that controlled the interaction of the TS3 cells with their target population. Thus, TS3 cells were activated in vitro with monoclonal H-2b or H-2k-derived TsF2. The activated TS3 cells were then adoptively transferred to TS3-depleted (cyclophosphamide-treated) recipients of various genotypes. When the TS3-containing lymph node population was activated in vitro for 2 h, suppressive activity was only noted in combinations of TSF2, TS3, and recipients that were matched at both the I-J and Igh gene complexes. The data indicate that TsF2 can activate TS3 cells and that both the activation and the interaction of TS3 cells are I-J and Igh restricted. Using (B10 x B10.BR)F1 mice as TS3 donors, we noted that H-2b-derived TsF2 activated these F1 TS3 cells to suppress NP-specific cutaneous sensitivity responses in H-2b but not in H-2k recipients. Reciprocal experiments using H-2k-derived TsF2 demonstrated that only an H-2k-restricted population was activated in the F1-derived TS3 cells. The simplest explanation to account for these observations is that two distinct populations, each of which is restricted to a parental I-J determinants, exists in the heterozygous F1 TS3 population. Furthermore, we demonstrated that both I-Jb and I-Jk determinants are expressed on F1-derived TS3 cells. These observations are discussed in terms of the mechanisms involved in immunoregulation.
Obituary Listing
Authors: Paul Barach
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
APIXABAN REDUCES HOSPITALIZATION IN PATIENTS WITH ATRIAL FIBRILLATION: AN ANALYSIS OF THE EFFECT OF APIXABAN THERAPY ON RESOURCE USE IN THE APIXABAN FOR REDUCTION IN STROKE AND OTHER THROMBOEMBOLIC EVENTS IN ATRIAL FIBRILLATION TRIAL
Authors: Patricia A. Cowper, Wenqin Pan, Kevin Anstrom, Judith Stafford, Renato Lopes, Linda Davidson-Ray, Lars Wallentin, Hemant Phatak, Jack Ansell, Paul Dorian, Steen Husted, John McMurray, P. Gabriel Steg, John Alexander, Christopher Granger, Daniel Mark
Journal: Journal of the American College of Cardiology (2013)
Absence of Hepatic Impairment in Long-term Oral-contraceptive Users
Authors: G. I. M. Swyer, V. Little
Journal: BMJ (1965)

Although it has long been known that certain steroids, particularly those with an alkylated group at C17, may occasionally prove hepatotoxic, no serious suspicion that currently used oral contraceptives might have such an action was generally entertained until Bisalo et al. (1964) presented evidence of hepatic dysfunction in seven post-menopausal women treated for 28 days with Lyndiol (17a-ethynyloestrenol 5 mg.and mestranol 0.15 mg.), at double the usual oral contraceptive dose in five of them.This evidence consisted of pathological increases in the serum transaminase levels in all cases and of high bromsulphthalein retention in the three cases tested; the total bilirubin was elevated in one case and the alkaline phosphatase in one case on the day following the treatment.The progestogen alone was found to be without hepatotoxic effect in two patients given it, and one out of three patients given mestranol alone showed a rise in serum transaminase.This report has been followed by several others dealing with oral contraceptives and liver damage.Thus Tyler (1964a) encountered abnormal bromsulphthalein retention and trans- aminase figures in " small percentages " of women using various oral contraceptives, but found "comparable" percentages among normal pregnant women.Palva and Mustala (1964), reporting like Eisalo et al. from Helsinki, treated five post-menopausal women for 28 days with Anovlar (norethisterone acetate 4 mg.and ethinyloestradiol 0.05 mg.) and found raised transaminase and B.S.P. retention in all cases, high serum bilirubin in two, and slightly elevated alkaline phosphatase in three.Linthorst (1964), on the other hand, could find no evidence for hepatic dysfunction in 52 women who had received long-term treatment with 17a-ethynyloestrenol (Orgametril), Lyndiol, or Lyndiol 2.5
Redesigning a Joint Replacement Program Using Lean Six Sigma in a Veterans Affairs Hospital
Authors: Benjamin Gayed, Stephen Black, Joanne Daggy, Imtiaz A. Munshi
Journal: JAMA Surgery (2013)

In April 2009, an analysis of joint replacement surgical procedures at the Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana, revealed that total hip and knee replacements incurred $1.4 million in non-Veterans Affairs (VA) care costs with an average length of stay of 6.1 days during fiscal year 2008. The Joint Replacement Program system redesign project was initiated following the Vision-Analysis-Team-Aim-Map-Measure-Change-Sustain (VA-TAMMCS) model to increase efficiency, decrease length of stay, and reduce non-VA care costs.To determine the effectiveness of Lean Six Sigma process improvement methods applied in a VA hospital.Perioperative processes for patients undergoing total joint replacement were redesigned following the VA-TAMMCS model--the VA's official, branded method of Lean Six Sigma process improvement. A multidisciplinary team including the orthopedic surgeons, frontline staff, and executive management identified waste in the current processes and initiated changes to reduce waste and increase efficiency. Data collection included a 1-year baseline period and a 20-month sustainment period.The primary endpoint was length of stay; a secondary analysis considered non-VA care cost reductions.Length of stay decreased 36% overall, decreasing from 5.3 days during the preproject period to 3.4 days during the 20-month sustainment period (P < .001). Non-VA care was completely eliminated for patients undergoing total hip and knee replacement at the Richard L. Roudebush Veterans Affairs Medical Center, producing an estimated return on investment of $1 million annually when compared with baseline cost and volumes. In addition, the volume of total joint replacements at this center increased during the data collection period.The success of the Joint Replacement Program demonstrates that VA-TAMMCS is an effective tool for Lean and Six Sigma process improvement initiatives in a surgical practice, producing a 36% sustained reduction in length of stay and completely eliminating non-VA care for total hip and knee replacements while increasing total joint replacement volume at this medical center.
Unmasking and Conversion of Gap Phenomenon in the Human Heart
Authors: MASOOD AKHTAR, ANTHONY N. DAMATO, WILLIAM P. BATSFORD, ANTONIO R. CARACTA, GUILLERMO VARGAS, SUN H. LAU
Journal: Circulation (1974)

Two types of gap phenomena (types I and II ) have been described in human hearts and their electrophysiologic bases have been delineated. In both types of gap phenomena relatively early premature atrial impulses are blocked within some portion of the His-Purkinje system (HPS). By increasing the prematurity of the atrial depolarization, conduction to the ventricles resumes due to delay of the premature impulse with the atrioventricular node (A-VN) (type I gap) or within the proximal HPS (type II gap). Gap phenomena are not observed when the refractory period of the A-VN exceeds that of the HPS. Since atropine decreases refractoriness of the A-V node, its effect on the gap phenomena was studied in nine subjects. After administration of atropine (0.2-0.5 mg i.v.) type I gap was demonstrated in six subjects and type II gap in three subjects. When atropine shortened the functional and effective refractory period (ERP) of the A-V node, premature atrial impulses arrived at the HPS during its ERP. By a similar mechanism, type I gap was converted into type II gap in three subjects following atropine administration. Decreasing the basic atrial drive rate converted type II gap into type I (two subjects) and ultimately abolished both types of gap phenomena in all subjects. These results suggest that the gap penomenon may be functional in nature and may be readily manifested or abolished by varying the refractoriness of the A-V node relative to that of the HPS.
Imipramine and "Drinamyl" in Depressive Illness: A Comparative Trial
Authors: E. H. Hare, C. McCance, W. O. McCormick
Journal: BMJ (1964)

<h3>Abstract</h3> Accurate prediction of protein structures is critical for understanding the biological function of proteins. Nevertheless, most structure optimization methods are built upon pre-defined statistical energy functions, which may be sub-optimal in formulating the conformation space. In this paper, we propose an end-to-end approach for protein structure optimization, powered by SE(3)-equivariant energy-based models. The conformation space is characterized by a SE(3)-equivariant graph neural network, with substantial modifications to embed the protein-specific domain knowledge. Furthermore, we introduce continuously-annealed Langevin dynamics as a novel sampling algorithm, and demonstrate that such process converges to native protein structures with theoretical guarantees. Extensive experiments indicate that SE(3)-Fold achieves comparable structure optimization accuracy, compared against state-of-the-art baselines, with over 1-2 orders of magnitude speed-up.
Prenatal Diagnosis of Congenital Toxoplasmosis with a Polymerase-Chain-Reaction Test on Amniotic Fluid
Authors: Patrick Hohlfeld, Fernand Daffos, Jean-Marc Costa, Philippe Thulliez, Francois Forestier, Michel Vidaud
Journal: New England Journal of Medicine (1994)

Congenital infection with Toxoplasma gondii can produce serious sequelae. However, there is little consensus about screening during pregnancy, and the tests used to establish a prenatal diagnosis of toxoplasmosis are complex and slow. We evaluated a simpler approach that is based on a polymerase-chain-reaction (PCR) test.
Our Nation's Great Public Hospitals
Authors: Larry S. Gage
Journal: JAMA (1987)

In recent years, health policy analysts and decision makers have increased their concern over the plight of uninsured patients, uncompensated care, and the changing complexion of the nation's health care system.<sup>1-4</sup>This period, however, has seen far less attention focused on the fragile, nationwide network of great public hospitals that already provides those health services—the institutions that serve in effect as America's national health insurance by default. While the Congress has sought repeatedly in the last several years to require extra attention in the Medicare and Medicaid programs to the need of such hospitals, it is only in the last several months that the Reagan Administration has finally been forced to provide such relief (1986 Consolidated Omnibus Budget Reconciliation Act [COBRA] Public Law 99-272). (See Gage L, Newman H: Lawsuits, legislation mean federal relief for ailing hospitals.<i>Legal Times</i>1987;9:14-16.) The series of four articles on public hospitals that is