tbuckley/cabot-search huggingface dataset:
Elephantiasis nostras verrucosa: beneficial effect of oral etretinate therapy
Authors: CH.C. ZOUBOULIS, S. BICZO, H. GOLLNICK, H.-J. REUPKE, G. RINCK, M. SZABO, J. FEKETE, C.E. ORFANOS
Journal: British Journal of Dermatology (1992)

Journal Article Elephantiasis nostras verrucosa: beneficial effect of oral etretinate therapy Get access CH.C. ZOUBOULIS, CH.C. ZOUBOULIS Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Germany Dr Ch.C.Zouboulis, Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Hindenburgdamm 30, W‐l000 Berlin 45, Germany. Search for other works by this author on: Oxford Academic Google Scholar S. BICZÓ, S. BICZÓ Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar H. GOLLNICK, H. GOLLNICK Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar H.‐J. REUPKE, H.‐J. REUPKE Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar G. RINCK, G. RINCK Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar M. SZABÓ, M. SZABÓ Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar J. FEKETE, J. FEKETE Departments of Pathology, 'Kaposi Mór' County Hospital, Kaposvár, Hungary Search for other works by this author on: Oxford Academic Google Scholar C.E. ORFANOS C.E. ORFANOS Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 4, 1 October 1992, Pages 411–416, https://doi.org/10.1111/j.1365-2133.1992.tb00465.x Published: 01 October 1992
AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas
Authors: Moshe Elkabets, Evangelos Pazarentzos, Dejan Juric, Qing Sheng, Raphael A. Pelossof, Samuel Brook, Ana Oaknin Benzaken, Jordi Rodon, Natasha Morse, Jenny Jiacheng Yan, Manway Liu, Rita Das, Yan Chen, Angela Tam, Huiqin Wang, Jinsheng Liang, Joseph M. Gurski, Darcy A. Kerr, Rafael Rosell, Cristina Teixidó, Alan Huang, Ronald A. Ghossein, Neal Rosen, Trever G. Bivona, Maurizio Scaltriti, José Baselga
Journal: Cancer Cell (2015)
Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use.
Authors: S Kaveri, T Vassilev, V Hurez, R Lengagne, C Lefranc, S Cot, P Pouletty, D Glotz, M D Kazatchkine
Journal: Journal of Clinical Investigation (1996)

Intravenous immunoglobulin (IVIg) is increasingly used for the treatment of autoimmune diseases and the prevention of infections and of graft versus host reactions in recipients of allogeneic bone marrow transplants. The immunomodulatory effects of IVIg are largely dependent on their ability to interact with membrane molecules of lymphocytes. We report here that IVIg recognizes the B07.75-84 peptide, corresponding to a conserved region of the alpha I helix of the first domain of HLA-B7 01, which represents a nonpolymorphic determinant of HLA class I molecules. Intact IVIg and its F(ab')2 fragments bound to the peptide as well as to purified soluble HLA and to HLA on a human T cell line. Binding of IVIg to HLA was assessed by ELISA, immunofluorescence, and real-time analysis of the interaction using the BIAlite system. The binding of antipeptide antibodies to HLA was inhibited by free peptide. Antipeptide antibodies isolated from IVIg by affinity chromatography inhibited CD8 cell-mediated cytotoxicity of an influenza virus-specific human T cell line. The presence in IVIg of antibodies to critical regions of HLA class 1 molecules suggests a possible role for IVIg in modulation of class-I-restricted cellular interactions in the immune response.
Diagnostic Quality in Endoscopic Retrograde Cholangiopancreatography: Comparison Between Iodixanol and Iopromide
Authors: D. F. Martin, R. E. England, T. Rösch, E. Biehl, B. Jeschke, N. Fritz, D. Heldwein, A. Klauser, A. Klaveness, D. Kristoffersen
Journal: Endoscopy (2000)

Background and Study Aims: The contrast medium for endoscopic retrograde cholangiopancreatography (ERCP) must produce adequate images, whilst keeping the risk of complications to a minimum. There is a theoretical reason to suppose that a dimeric isosmolar medium may be superior to a monomeric hyperosmolar medium. We have compared two such media in a triple-centre double-blind randomized study on patients referred with a clinical indication for ERCP.
Cyclooxygenase-2 Modulates the Insulin-Like Growth Factor Axis in Non–Small-Cell Lung Cancer
Authors: Mehis Põld, Kostyantyn Krysan, Anu Põld, Mariam Dohadwala, Nathalie Heuze-Vourc’h, Jenny T. Mao, Karen L. Riedl, Sherven Sharma, Steven M. Dubinett
Journal: Cancer Research (2004)

Abstract Constitutive overexpression of cyclooxygenase-2 (COX-2) occurs frequently in several different malignancies, including lung, colon, breast, and prostate cancer. Clinical studies have established elevated serum insulin-like growth factor (IGF-I) content and IGF-I:IGF-binding protein 3 (IGFBP-3) ratio as risk factors for these same malignancies. Therefore, we sought to determine the link between COX-2 expression and the IGF axis in COX-2 gene-modified human non–small-cell lung cancer (NSCLC) cells. Overexpression of COX-2 in NSCLC cells enhanced the antiapoptotic and mitogenic effects of IGF-I and IGF-II, facilitated the autophosphorylation of the type 1 IGF receptor, increased class IA phosphatidylinositol 3′-kinase activity, and decreased expression of IGFBP-3. Thus, these findings show that COX-2 augments the stimulatory arm of the IGF axis.
Maturation of the response to bradykinin in resistance and conduit pulmonary arteries
Authors: P Boels
Journal: Cardiovascular Research (1999)

Objective: Immaturity of the endothelial-dependent relaxation is thought to be characteristic of the newborn pulmonary elastic arteries. In adulthood, the reactivity of different pulmonary arterial segments varies. Therefore, we investigated the presence of endothelial heterogeneity in perinatal porcine pulmonary arteries and compared it with the adult by studying the bradykinin-, substance P- and acetylcholine-induced relaxations in different arteries. Methods: Three types of pulmonary arteries (large conduit elastic, distal branching and resistance-sized; in situ diameters 0.7–1.7, 0.3–0.5 and 0.1–0.2 mm, respectively) were isolated from lungs of adult (nine months), young (60–84 h), newborn (4 min) and near-term foetal pigs. They were mounted for isometric force recording, contracted first with K+=125 mmol/l (reference contraction). Cumulative concentration—response curves to acetylcholine, substance P or bradykinin were obtained from prostaglandin F2α (30 μmol/l) precontracted vessels. The effects of captopril and O2(95 or 8%) were also determined. Experiments were terminated by adding 100 μmol/l papaverine, obtaining maximal relaxation, which was used for normalising relaxations. Results: (i) Acetylcholine: In resistance arteries, relaxations were absent in the newborn and the adult. In conduit arteries, they were present from 60–84 h onward. (ii) Substance P: In resistance arteries, relaxations were only present in the adult. In the other two types of arteries, rudimentary relaxations were present from the mature foetal stage onward. (iii) Bradykinin: In resistance arteries, identical relaxations were present at all ages which, in the foetus and the adult, were insensitive to changes in O2 levels (95 to 8%). In conduit arteries, concentration-dependent relaxations were present from birth, increasing in amplitude with age and these were potentiated by captopril. Foetal conduit arteries relaxed to the single application of 0.1 μmol/l bradykinin, indicating age-dependent tachyphylaxis. Conclusions: (i) Bradykinin is unique among endothelium-dependent vasodilators in being able to relax all vascular segments, at all ages, subject to tachyphylaxis and bradykinin-breakdown but independent of the prevailing O2 concentration. (ii) Heterogeneity of the relaxations between conduit and resistance arteries is evident from the mature foetal stage onward. (iii) The type of agonist, the type of vessel and the age each independently determine the presence or absence of endothelial relaxations. Therefore, the perinatal pulmonary circulation is not immature with respect to endothelial-dependent relaxation; rather, the nature of this process changes within the perinatal period and between birth and adulthood.
A LIGATION OF THE EXTERNAL ILIAC ARTERY.
Authors: A. C. SMITH
Journal: JAMA (1904)

Following is a report of a case in which the righ external iliac artery was ligated for the cure of an aneur m of the common femoral: <h3>History.</h3> —G. M., age 30 years; nativity, Massachusetts; color, white; admitted into hospital May 24, 1904, suffering with an aneurism of the right common femoral artery. The patient had been aware of the existence of the affection for about six weeks. The tumor resembled a small bubo, just below Poupart's ligament. Expansile pulsation very perceptible. No history of syphilis. Arteries elsewhere soft and pliable. No disease of heart, lungs or kidneys. Physique slender, but well nourished. The patient gave a history of having had a suppurating bubo in the right groin eleven years before, which burst spontaneously while he was at sea and which left a sear, slightly above the level of the aneurism. He was unwilling at first to undergo
Does adding routine antibiotics to animal feed pose a serious risk to human health?
Authors: D. Wallinga, D. G. S. Burch
Journal: BMJ (2013)

As fears rise over resistance, some countries have banned routine use of antibiotics in animal feed. <b>David Wallinga</b> says a ban is possible without damaging food productivity, but <b>David G S Burch</b> argues that the drugs used in agriculture are not those causing problems with resistance in humans
Newborns Killed or Left to Die by a Parent
Authors: Marcia E. Herman-Giddens, Jamie B. Smith, Manjoo Mittal, Mandie Carlson, John D. Butts
Journal: JAMA (2003)

<h3>Context</h3> Interest in the discarding or killing of newborns by parents has increased due to wide news coverage and efforts by states to provide Safe Haven legislation to combat the problem. <h3>Objective</h3> To describe the characteristics of these cases in North Carolina. <h3>Design, Setting, and Population</h3> Case series derived from data on all deaths among liveborn infants 0 to 4 days of age reported to the North Carolina medical examiner from 1985 through 2000. <h3>Main Outcome Measures</h3> Incidence of newborns known to have been killed or discarded by a parent; epidemiological characteristics of newborns and parents. <h3>Results</h3> There were 34 newborns known to have been killed or discarded by a parent, comprising 0.002% of all liveborn infants during the 16-year study period, giving a rate of 2.1 per 100 000 per year. A total of 58.8% were male, 41.1% were white, and 52.9% were black. For 29 cases, the perpetrator was determined to be the mother. Among mothers, 50% were single and 20.6% were married (marital status of the remainder was unknown). Thirty-five percent had had other children. Eight mothers (23.5%) were known to have received some prenatal care. The mean age of the mothers was 19.1 years (range, 14-35 years) and more than half were aged 18 years or older. The most common causes of death were asphyxiation/strangulation (41.1%) and drowning (26.5%). <h3>Conclusions</h3> In North Carolina, at least 2.1 per 100 000 newborns are known to be killed or left to die per year, usually by their mothers. It is unknown how many of these deaths might be prevented by Safe Haven laws. Efforts to educate the public about these laws need to target the general public. Where resources are limited, the focus should be on on adolescent pregnancy prevention programs, young adults, prenatal care clinics, and married women.
<i>Helicobacter pylori</i>targets dendritic cells to induce immune tolerance, promote persistence and confer protection against allergic asthma
Authors: Mathias Oertli, Anne Müller
Journal: Gut Microbes (2012)

The bacterial pathogen Helicobacter pylori is predominantly known for its tight association with peptic ulcer disease and gastric cancer. However, recent evidence suggests that chronic infection with H. pylori may also be beneficial to the host by conferring protection against allergies, asthma and inflammatory bowel diseases. The protective effects of H. pylori depend on highly suppressive regulatory T-cells. In this addendum, we summarize results showing that H. pylori infection efficiently re-programs dendritic cells (DCs) toward a tolerance-promoting phenotype; their "tolerogenic" activity requires inflammasome activation and the secretion of interleukin-18. H. pylori-experienced DCs fail to induce T-cell effector functions, but efficiently induce FoxP3 expression in naive T-cells in vitro and in vivo. The experimental depletion of DCs breaks tolerance and results in improved infection control, but also in aggravated T-cell-driven immunopathology. In summary, we propose that H. pylori evades adaptive immune responses by re-programming DCs in favor of tolerance over immunity.
Radionuclide Imaging of Neurohormonal System of the Heart
Authors: Xinyu Chen, Rudolf A. Werner, Mehrbod S. Javadi, Yoshifumi Maya, Michael Decker, Constantin Lapa, Ken Herrmann, Takahiro Higuchi
Journal: Theranostics (2015)

Heart failure is one of the growing causes of death especially in developed countries due to longer life expectancy.Although many pharmacological and instrumental therapeutic approaches have been introduced for prevention and treatment of heart failure, there are still limitations and challenges.Nuclear cardiology has experienced rapid growth in the last few decades, in particular the application of single photon emission computed tomography (SPECT) and positron emission tomography (PET), which allow non-invasive functional assessment of cardiac condition including neurohormonal systems involved in heart failure; its application has dramatically improved the capacity for fundamental research and clinical diagnosis.In this article, we review the current status of applying radionuclide technology in non-invasive imaging of neurohormonal system in the heart, especially focusing on the tracers that are currently available.A short discussion about disadvantages and perspectives is also included.
The Intermediate Medical Care Unit at Bellevue Hospital Medical Center: 3 years' Experience.
Authors: Stephen H. Leslie
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972The Intermediate Medical Care Unit at Bellevue Hospital Medical Center: 3 years' Experience.Stephen H. Leslie, M.D., F.A.C.P., A. R. Berger, M.D., F.A.C.P.Stephen H. Leslie, M.D., F.A.C.P.Search for more papers by this author, A. R. Berger, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-856_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA method of providing more efficient acute medical care in a large, municipal, university-affiliated teaching hospital was achieved by the introduction of an intermediate medical care unit within the Department of Medicine. Four wards, containing 104 beds (78 men, 26 women) serviced the General Medical Division (208 beds) and the Medical Chest Division (148 beds). The staff consisted of seven full-time, salaried ECFMG (Education Council for Foreign Medical Graduates) physicians with 3 years of approved American residency training. They were supervised by four part-time attending physicians from the clinical staff of the Department of Medicine.Patients were eligible for transfer... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 856-856KeywordsGraduate medical educationHospital medicineResidencyThorax Issue Published: 1 May 1972 PDF downloadLoading ...
Phospholipid composition and organization in model β-thalassemic erythrocytes
Authors: Frans A. Kuypers, Mary Ann Schott, Mark D. Scott
Journal: American Journal of Hematology (1996)

The membrane phospholipid organization in human red blood cells (RBC) is rigidly maintained by a complex system of enzymes. However, several elements of this system are sensitive to oxidative damage. An important component in the destruction of β-thalassemic RBC is the generation of reactive oxygen species and the release of redox-active iron by the unpaired α-hemoglobin chains. Consequently, we hypothesized that the presence of this oxidative stress to the RBC membrane could lead to alterations in membrane lipid organization. Model β thalassemic RBC, prepared by the introduction of excess α-globin in the cell, have previously been shown to exhibit structural and functional changes almost identical to those observed in β-thalassemic cells. After 24 hr at 37°C, the model β thalassemic cells exhibited a significant loss of deformability, as measured by ektacytometric analysis, indicative of extensive membrane damage. However, a normal steady-state distribution of endogenous phospholipids was found, as evidenced by the accessibility of membrane phospholipids to hydrolysis by phospholipases. Similarly, the kinetics of transbilayer movement of spin-labeled phosphatidylserine (PS) and phosphatidylethanolamine (PE) in all samples was in the normal range and was not affected by the presence of excess α-globin chains. In contrast, a faster rate of spin-labeled phosphatidylcholine (PC) transbilayer movement was observed in these cells. While control RBC exhibited a complete loss of their initial (2 mol%) lysophosphatidylcholine (LPC) levels following 24 hr of incubation at 37°C, 1.5 mol% LPC was still present in model β-thalassemic cells, suggesting an altered phospholipid molecular species turnover, possibly as a result of an increased repair of oxidatively damaged phospholipids. © 1996 Wiley-Liss, Inc.
Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
Authors: Zhizhong Li, Shideng Bao, Qiulian Wu, Hui Wang, Christine Eyler, Sith Sathornsumetee, Qing Shi, Yiting Cao, Justin Lathia, Roger E. McLendon, Anita B. Hjelmeland, Jeremy N. Rich
Journal: Cancer Cell (2009)
Recurrent Carcinoma of the Ovary, Unusual Manifestations and Management Problems.
Authors: Robert W. Talley
Journal: Annals of Internal Medicine (1966)

s1 May 1966Recurrent Carcinoma of the Ovary, Unusual Manifestations and Management Problems.Robert W. Talley, M.D., F.A.C.P., Robert M. O. Brayan, M.D., Emily L. San Diego, M.D., Michael J. Brennan, M.D., F.A.C.P., John Burrows, M.D.Robert W. Talley, M.D., F.A.C.P.Search for more papers by this author, Robert M. O. Brayan, M.D.Search for more papers by this author, Emily L. San Diego, M.D.Search for more papers by this author, Michael J. Brennan, M.D., F.A.C.P.Search for more papers by this author, John Burrows, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1177_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCarcinoma of the ovary accounts for approximately 5% of all female cancers, and because it is frequently not diagnosed until late, management of the disease is frequently palliative. Because of the complications encountered in recurrent disease such as pulmonary symptoms due to pleural effusion, electrolyte imbalance associated with prolonged partial obstruction, internists frequently are called to help with the management of these patients. In a review of 100 patients with recurrent ovarian malignancies, three patients with hypercalcemia without bone metastases were encountered, two patients with pericardial effusion required repeated pericardiocenteses as well as many patients with severe electrolyte disturbances.The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPara-endocrine hypercalcemia in ovarian neoplasms.Report of mesonephroma with hypercalcemia and review of literature 1 May 1966Volume 64, Issue 5Page: 1177-1177KeywordsBoneHypercalcemiaOvariesPleural effusionPulmonary diseases Issue Published: 1 May 1966 PDF downloadLoading ...
Atropine Poisoning
Authors: Eben Alexander, Donald P. Morris, Ralph L. Eslick
Journal: New England Journal of Medicine (1946)

THE effects of atropine when given in therapeutic doses are dramatic. When it is given in doses that may cause poisoning, the results are sometimes extremely serious or even fatal. The exact incidence of such poisoning is not known. Deaths from this cause constituted an extremely small percentage of those from poisoning in Massachusetts from 1928 to 1937 — considerably less than 1 per cent.1 There are several reports of cases of poisoning and of recovery with doses of atropine varying from 0.4 to 100 mg.3 4 5 6 7 In each of these cases the reaction followed a distinct pattern, the differences between . . .
Geographic Location and State Hospital Utilization
Authors: PETER WEISS, JACQUELINE R. MACAULAY, ALLEN PINCUS
Journal: American Journal of Psychiatry (1967)

In this study, the distance between the state hospital and the community was found to be a factor influencing the use of the hospital. As this distance increased the admission rate decreased, the proportion of court commitments increased, and the degree of impairment requiring confinement became more severe. While the expectation that the proportion of voluntary admissions would decrease with increasing distance was not confirmed, the community near the state hospital did exhibit greater diversity in hospitalization decisions.
Testosterone Deficiency and Replacement in Older Men
Authors: William J. Bremner
Journal: New England Journal of Medicine (2010)

It is now clear that men have gradual declines in average serum testosterone levels as they age. These decreases begin by middle age and continue into old age.1,2 Although the decreases are substantial in many men, they are quite variable. Some men, even in old age, maintain serum testosterone levels similar to those of healthy young men.Many of the physical and behavioral changes that occur in men as they age are similar to those that occur in younger men with hypogonadism. These changes include decreases in muscle mass, strength, bone mass, and sexual function and increases in body . . .