tbuckley/cabot-search huggingface dataset:
The Contribution of His Bundle Recording to the Understanding of Cardiac Conduction in Man
Authors: KENNETH M. ROSEN
Journal: Circulation (1971)

IN 1969, Scherlag and coworkers reported the recording of bundle of His electro- grams in man.1 The technique consists of passing an electrode catheter into the right heart and positioning the electrodes in the area of the tricuspid valve.With proper catheter positioning, amplffication and fre- quency filtering, the His bundle (H) potential can reliably be recorded as a bi-or triphasic deflection between the atrial and ventricular electrograms.The procedure is simple and has a low morbidity.With a little experience, recording of His bundle electrograms could be accomplished in most cardiac laboratories.Careful attention must be given to elimination of electrical hazards before attempting this procedure.The technique has been applied to the study of both normal and abnormal conduc- tion in man.Many of the findings demonstrat- ed had previously been predicted by the physiologist, the electrocardiographer, and the cardiac pathologist.The recording of the H potential allows subdivision of the P-R interval into two subintervals, P-H (A-H) and H-Q (H-V) (fig.1).1, 2,3 P-H is conduction time from the onset of atrial depolarization (P wave) to that of His bundle depolarization and is a measure of intra-atrial and A-V nodal conduction times.H-Q is conduction time from His bundle
Tissue inhibitor of metalloproteinases-3 interacts with angiotensin II type 2 receptor and additively inhibits angiogenesis
Authors: Kyo-Hwa Kang, Sang-Yoon Park, Seung Bae Rho, Je-Ho Lee
Journal: Cardiovascular Research (2008)

AimThe tissue inhibitors of metalloproteinases (TIMPs) are complex molecules with both pro- and anti-tumour effects. Thus, their diverse expression could be because of their multifunctional properties with respect to tumour growth, angiogenesis, apoptosis, and other biological functions. Previous data have shown that TIMPs bind tightly to most matrix metalloproteinases, although the pathway that mediates angiostatic activity has not been fully established.
Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies
Authors: Marija Geroldinger-Simic, Thomas Zelniker, Werner Aberer, Christof Ebner, Cornelia Egger, Antonia Greiderer, Nicole Prem, Jonas Lidholm, Barbara K. Ballmer-Weber, Stefan Vieths, Barbara Bohle
Journal: Journal of Allergy and Clinical Immunology (2011)
Johns Hopkins scales down its deal with cosmetics firm after criticism
Authors: David Brown
Journal: BMJ (2006)

The value of the name of Johns Hopkins, the 19th century Quaker philanthropist who endowed one of the great medical institutions of the United States, is at the centre of a public debate that is forcing US academic medicine to think hard about what happens when science meets branding.

In late February a New York cosmetics company, Klinger Advanced Aesthetics, announced the release of a line of products called “Cosmedicine.” The 15 skin products, whose prices range from $28 (£16; €23) to $85, included hydrators, exfoliators, pore shrinkers, sun blockers, and shine suppressors.

The marketing pitch of the new products was that their biological performance was scientifically verified, unlike that of nearly all their competitors. The …
Clinical decision making: from theory to practice. Designing a practice policy. Standards, guidelines, and options
Authors: D. M. Eddy
Journal: JAMA (1990)

DESIGNING a practice policy is similar to making a decision for an individual patient. In both cases, one must identify the available options, estimate the consequences of the different options, and determine the desirability of those outcomes to patients. Practice policies can be thought of as generic decisions—recommendations intended for a collection of patients rather than for a single patient. Beyond these similarities, however, are some important differences that make practice policies considerably more difficult to design. In the case of a decision, the outcomes and preferences apply to a particular patient. There might be a range of uncertainty about the outcomes, the comparisons might be difficult, and there will be varying degrees of conviction about which option is best, but, in theory at least, there is a single option that is best for that patient. Practice policies are inherently more difficult because they attempt to make decisions for a
The Association of Bacteriuria with Resident Characteristics and Survival in Elderly Institutionalized Men
Authors: LINDSAY E. NICOLLE
Journal: Annals of Internal Medicine (1987)

Ninety-one elderly male residents of a skilled nursing facility were classified as nonbacteriuric (41%), intermittently bacteriuric (34%), or continuously bacteriuric (25%) on the basis of urine cultures obtained over a 3-year period. Bacteriuric and nonbacteriuric residents were similar in age, number of diagnoses and medications, and mobility. However, bacteriuric residents were more frequently confused or demented, whether continuously bacteriuric (78%) or intermittently bacteriuric (62%) compared with nonbacteriuric residents (42%) (p less than 0.04). In addition, bacteriuria was significantly associated with incontinence of bladder (96% of continuous, 66% of intermittent, and 25% of nonbacteriuric; p less than 0.001) and bowel (52%, 39%, and 5.5%, respectively; p less than 0.002). At 6 years of follow-up there were no differences in survival among the three groups. Urinary tract infection caused or contributed to only two (2.9%) deaths. Thus, in this population, bacteriuria was associated with higher functional disability but not with increased mortality.
Transient Ischemic Attack — Proposal for a New Definition
Authors: Gregory W. Albers, Louis R. Caplan, J. Donald Easton, Pierre B. Fayad, J. P. Mohr, Jeffrey L. Saver, David G. Sherman
Journal: New England Journal of Medicine (2002)

The definition of transient ischemic attack (TIA) and the assumptions underlying the definition have been out of date for some time and are no longer consistent with current concepts of brain ischemia. The classic definition of TIA is a sudden, focal neurologic deficit that lasts for less than 24 hours, is presumed to be of vascular origin, and is confined to an area of the brain or eye perfused by a specific artery. Typical symptoms include hemiparesis, hemiparesthesia, dysarthria, dysphasia, diplopia, circumoral numbness, imbalance, and monocular blindness. TIAs are often referred to as ministrokes, warning strokes, or transient strokes because . . .
Abnormalities of myeloid progenitor cells after "successful" bone marrow transplantation.
Authors: S Li, R Champlin, J H Fitchen, R P Gale
Journal: Journal of Clinical Investigation (1985)

We studied recovery of peripheral blood- and bone marrow-derived myeloid progenitor cells (CFU-G,M) in 29 patients who received bone marrow transplants 2 mo to 8.5 yr previously. All patients had normal levels of peripheral blood neutrophils, normal bone marrow cellularity, and a normal myeloid-erythroid ratio. Both peripheral blood- and bone marrow-derived CFU-G,M were markedly reduced compared with normal controls and bone marrow donors [5 +/- 1/10(6) vs. 37 +/- 4/10(6) (P less than 0.001) and 23 +/- 5/2 x 10(5) vs. 170 +/- 21/2 x 10(5) (P less than 0.001)]. Five patients had no detectable CFU-G,M even when 10(6) bone marrow cels were plated. These abnormalities of CFU-G,M were unrelated to age, sex, diagnosis, conditioning regimen, dose of bone marrow cells transplanted, and presence or absence of graft-vs.-host disease. Patients who received either autotransplants or transplants from identical twins also had decreased or absent CFU-G,M indicating that allogeneic factors and posttransplant immune suppressor with methotrexate or corticosteroids were not major determinants of this abnormality. Co-culture of normal or donor peripheral blood or bone marrow mononuclear cells with recipients peripheral blood or bone marrow mononuclear cells, purified T cells, or serum failed to show any evidence of active CFU-G,M suppression. Furthermore, the abnormality of CFU-G,M could not be corrected by the addition of normal syngeneic (donor) hematopoietic cells or serum. Depletion of T-cells from recipient bone marrow by physical techniques resulted in marked increase in CFU-G,M (36 +/- 13 vs. 138 +/- 36; P less than 0.05). The abnormality could be reproduced in vitro by readdition of autologous T cells. In contrast to results with T cell depletion by physical techniques, T cell depletion with a monoclonal anti-T antibody (B7) and complement had no effect. These data indicate that most-transplant recipients have a marked abnormality in CFU-G,M when these cells are cultured in vitro. In at least some of these patients, the decreased cloning efficiency of CFU-G,M appears to be mediated by a suppressive effect of autologous T cells.
1084-169 Efficacy and safety of ezetimibe coadministered with simvastatin versus simvastatin alone in thiazolidinedione-treated patients with type 2 diabetes mellitus
Authors: Linda Gaudiani, Andrew Lewin, Luigi Meneghini, Inna Perevozskaya, Jonathan Tobert, Diane Plotkin, Yale Mitchel, Sukrut Shah
Journal: Journal of the American College of Cardiology (2004)
Local delivery of 125 l-labeled ReoPro to baboon brachial arteries using an iontophoretic balloon catheter
Authors: K.A. Robinson, B. Sundell, J. Cui, S. Ishiwata, N.A.F. Chronos, A.B. Kelly, R.G. Walsh, R. Jordan, L.A. Harker, S.R. Hanson
Journal: Journal of the American College of Cardiology (1998)
Consent for Autopsies
Authors: Susan Schmidt
Journal: JAMA (1983)

DIFFERENT laws apply to the granting of permission to perform an autopsy, depending on whether authorization is ordered primarily for legal purposes or requested for medical purposes. Generally, the surviving spouse or next of kin of the deceased can authorize or prohibit an autopsy. This article explores the consent issues, emphasizing the variations among the applicable state laws. The various autopsy laws are analyzed and compared. <h3>MEDICAL AUTOPSIES BY CONSENT</h3> Proper authorization for a nonofficial autopsy must be obtained to avoid possible civil or criminal liability of the physician performing the autopsy. A legal action for damages against a physician, coroner, or medical examiner can arise when the autopsy has not been consented to by the proper party, unless otherwise provided by law. In general, the person with the right or duty to dispose of the body is entitled to possession and receipt of the body without delay, in the
Canada's obstetricians call for a national birthing strategy
Authors: Barbara Kermode-Scott
Journal: BMJ (2006)

Canada is facing a crisis in obstetric care because more women are dying in childbirth and the country's position relative to other countries for infant and perinatal mortality has fallen, the Society of Obstetricians and Gynaecologists of Canada says.

The country must address shortages in maternity care staff and investigate ways to provide optimal care of mothers and newborns to achieve better outcomes, the society says.

Data from the Organisation for Economic Co-operation and Development show that in 1990 Canada was one of the world's safest places to give birth, ranking sixth on …
Controlling the NHS drugs budget Recommendations may not help
Authors: C M Harris, I W Marshall, J Gaffin
Journal: BMJ (1994)

are referred to local plastic surgeons who are fully trained and equipped to deal with this type of problem.The type of excision required usually necessitates large areas of skin grafting.Wounds of this size are regularly dealt with by bums and plastic surgery nurses; if small numbers are treated in peripheral district general hospitals the nursing skill required is usually not available.Early referral of these patients is essential for both their survival and their continuing care.
Female-to-Male Transmission of HTLV-III
Authors: Randolph F. Wykoff
Journal: JAMA (1986)

To the Editor.—  A number of articles in a recent issue ofThe Journalconcerned heterosexual transmission of human T-cell lymphotropic virus type III (HTLV-III). 1-3   While HTLV-III transmission from semen donor to semen recipient (either male to female or male to male) is well documented, the reverse route of transmission (female to male) is not. The evidence, to date, to support such transmission remains entirely based on untested epidemiologic observations.  Dr Redfield and his colleagues are to be congratulated for their continued efforts to provide evidence for both male-to-female and female-to-male transmission of infection and disease.1 I am not convinced, however, that they have yet completely succeeded in their goal.  They report on ten men with HTLV-III-associated diseases who denied traditional risk factors. Eight of the ten reported multiple sexual contacts (>50 in the past five years), including, in most, a history of sex with prostitutes. They report, in
Forensic Medicine: A Guide to Principles
Authors: Milton G. Bohrod
Journal: JAMA (1975)

<b>Color Atlas of Forensic Pathology,</b>by G. Austin Gresham, 304 pp, 295 illus, Chicago, Year Book, 1975. The emergence of forensic pathology as a specialty has seen the appearance of numerous books in the field, most of them good. One is tempted to look for the single best one to recommend to students and practitioners, but unfortunately, this is not possible. Gordon and Shapiro's book is based on South African experience but there is little in it that needs qualification for American readers. It is well written, not verbose, and enlivened by many colorful sentences. Definitions are clear and concise, and the text is not dogmatic. It is based on its authors' experience; therein lies its strength and its weakness, for it is lengthy and complete on subjects in which the authors are interested, but skimpy on other things. There is a detailed analysis of one case of arsenic poisoning,
Drip Infusion Pyelography
Authors: Avery D. Pratt
Journal: JAMA (1967)

In a series of 2,600 cases at the Christ Hospital, drip infusion pyelography has been demonstrated to be as safe and well-tolerated as standard-dose pyelography; and drip infusion pyelography produces much better visualization. The improvement in visualization of the collecting systems led to a 30% reduction in the number of retrograde pyelograms performed. Drip infusion pyelography has become our routine method of examining the urinary tract with contrast materials.
Surgically Created Arteriovenous Fistulas
Authors: Robert M. Steckler
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Drs. Ries, Perkins, and Ehrenfeld used saphenous vein arteriovenous fistulas to replace factor VIII in hemophiliacs (226:665, 1973). During the past year, at the M. D. Anderson Hospital and Tumor Institute in Houston, we have been creating arteriovenous fistulas at the wrist in patients with a diagnosis of acute leukemia. These patients often present a problem similar to that in hemophiliacs. With continuous intravenous chemotherapy in the face of need for frequent venipunctures to monitor blood chemistries, these patients rapidly "run out of veins." The search for a suitable vein through which to administer medication then becomes an agonizing experience for the patient and a frustrating one for the physician. By creating these fistulas as soon as the diagnosis is made, we are able to establish suitable fistulas in the wrist before the veins have become thrombosed. We have not found it necessary to use saphenous vein
Psychiatric Side Effects of Prescription and Over-the-Counter Medications: Recognition and Management
Authors: William A. Scheftner
Journal: Annals of Internal Medicine (1998)

Medical Writings1 December 1998Psychiatric Side Effects of Prescription and Over-the-Counter Medications: Recognition and ManagementWilliam A. Scheftner, MDWilliam A. Scheftner, MDRush Medical College, Chicago, IllinoisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-11_Part_1-199812010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Psychiatric Side Effects of Prescription and Over-the-Counter Medications: Recognition and Management; Brown TM, Stoudemire A. 443 pages. Washington, DC: American Psychiatric Pr; 1998. $75.00. ISBN 0880488689. Order phone 800-368-5777.Field of medicine: Internal medicine (including subspecialties) and psychiatry.Format: Hardcover book.Audience: The authors aim the book broadly to “clinical scientists … patients, physicians, and pharmacologists.” I believe that it was written for medical students, psychiatric residents, primary care residents, and subspecialty fellows and their attendings. Because of professional judgment issues, it is only secondarily useful to patients and their relatives. It is particularly helpful to anyone involved with consultation ... Author, Article, and Disclosure InformationAffiliations: Rush Medical College, Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1998Volume 129, Issue 11_Part_1Page: 919-920KeywordsAdverse reactionsAntioxidantsDrug interactionsDrug therapyInternetScientistsSub-specialty careToxicity ePublished: 15 August 2000 Issue Published: 1 December 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Mechanisms imposing the Vβ bias of Vα14 natural killer T cells and consequences for microbial glycolipid recognition
Authors: Datsen G. Wei, Shane A. Curran, Paul B. Savage, Luc Teyton, Albert Bendelac
Journal: The Journal of Experimental Medicine (2006)

Mouse and human natural killer T (NKT) cells recognize a restricted set of glycosphingolipids presented by CD1d molecules, including self iGb3 and microbial α-glycuronosylceramides. The importance of the canonical Vα14-Jα18 TCR α chain for antigen recognition by NKT cells is well recognized, but the mechanisms underlying the Vβ8, Vβ7, and Vβ2 bias in mouse have not been explored. To study the influences of thymic selection and the constraints of pairing with Vα14-Jα18, we have created a population of mature T cells expressing Vα14-Jα18 TCR α chain in CD1d-deficient mice and studied its recognition properties in vitro and in vivo. Transgenic cells expressed a diverse Vβ repertoire but their recognition of endogenous ligands and synthetic iGb3 was restricted to the same biased Vβ repertoire as expressed in natural NKT cells. In contrast, α-GalCer, a synthetic homologue of microbial α-glycuronosylceramides, was recognized by a broader set of Vβ chains, including the biased NKT set but also Vβ6, Vβ9, Vβ10, and Vβ14. These surprising findings demonstrate that, whereas Vβ8, Vβ7, and Vβ2 represent the optimal solution for recognition of endogenous ligand, many Vβ chains that are potentially useful for the recognition of foreign lipids fail to be selected in the NKT cell repertoire.
Intercurrent complications in chronic alcoholic men admitted to the intensive care unit following trauma
Authors: C. D. Spies, B. Neuner, T. Neumann, S. Blum, C. Müller, H. Rommelspacher, A. Rieger, C. Sanft, M. Specht, L. Hannemann, H. W. Striebel, W. Schaffartzik
Journal: Intensive Care Medicine (1996)
SEGMENTAL SPINE MOBILITY IN MEMBERS OF POLISH WOMEN'S VOLLEYBALL NATIONAL TEAM
Authors: J Lewandowski, M Ogurkowska
Journal: British Journal of Sports Medicine (2014)

Background Accurate knowledge of the body build of top sports level volleyball player's is an important information as it is the basis for designation of model body build parameters, body proportions, and build type for a given playing position. Objective The main objectives of this study are to define angle values of physiological curvature and segmental spine mobility of the women's volleyball national team members. Design In order to obtain a complete picture of the female players' profile, to-date studies would need to be extended by knowledge on spondylometric characteristics of women playing volleyball professionally. Setting Studies of somatic and spondylometric characteristics were performed using the tensometric electrogoniometry system. Percentile ranks of somatic and spondylometric characteristics of the female player subject were devised. Participants The material includes 12 female players of Polish women's volleyball national team aged 20–27. The control group comprised female players from clubs competing in the Polish Women's Volleyball League. Main outcome measurements Although volleyball is considered a no-contact sports discipline, the player's body – including the spine – is exposed to loads related to performing various elements of the game. In particular, major loads with vertical direction are related to the player's jumping to attack or block, and may be the cause of deformations. Spondylometric characteristics of the female player subjects are slightly different from those of athletes in other sports disciplines where jumping ability is the leading feature. Results In the elite of Polish female volleyball players lumbar lordosis is dominant (33% above normal values), then cervical lordosis, while thoracic kyphosis is significantly flattened. Range of segmental spine mobility in most cases is lower than the adopted normal values. Significant forward flexion movement limitation in the thoracic section was observed. No functional symmetrisation of the subjects was observed.
Epidemic Transmission of Enterically Transmitted Non-A, Non-B Hepatitis in Mexico, 1986-1987
Authors: Oscar Velazquez
Journal: JAMA (1990)

Outbreaks of acute hepatitis occurred in Huitzililla and Telixtac, two rural villages 70 miles south of Mexico City, Mexico, in late 1986. The first outbreak began in Huitzililla in June of that year, 1 month after the start of the rainy season. A census revealed 94 icteric case subjects, for an attack rate of 5%; two women died. Attack rates were higher for persons older than 15 years (10%) than for younger persons. A case-control study showed that illness was highly associated with water-related factors. The second outbreak began in August 1986 in Telixtac. There were 129 case subjects, for an attack rate of 6%; one woman died. Epidemiologic findings were similar to those in Huitzililla, except that most disease transmission was not linked to unsafe water sources. None of 62 case subjects in Huitzililla and only 2 of 53 case subjects in Telixtac tested had serological evidence for recent infection with hepatitis A or B. Two of eight stool samples from Huitzililla and one of eight stool samples from Telixtac were positive by immune electron microscopy for 32- to 34-nm viruslike particles similar to those seen in cases of enterically transmitted non-A, non-B hepatitis from Asia. To our knowledge, these investigations document for the first time the epidemic transmission of enterically transmitted non-A, non-B hepatitis virus in the Americas. (<i>JAMA</i>. 1990;263:3281-3285)
Microcirculation and Traditional Chinese Medicine
Authors: Xiu Rui-Juan
Journal: JAMA (1988)

THROUGHOUT their long history, the Chinese people have had a rich culture. Their ancient achievements are known to everyone. Porcelain, paper, and natural silk all originated in China and were spread throughout the world. However, China's enduring contributions to civilization are not limited to astronomy, printing, or other inventions. A wealth of experience in the art of healing, accumulated over thousands of years, has enabled China to achieve notable results in this field as well. And recently these results have become increasingly recognized by the rest of the world. In this article I would like to show that traditional Chinese medicine has been, in its own way, incidentally related to the microcirculation. The development of Chinese medicine into what it is today has been a long process. More than 600 000 years ago, Peking Man knew how to use fire to stay warm and to ward off wild animals so