Bromergocryptine and the Galactorrhea-Amenorrhea Syndrome
Authors: LAURENCE E. STEMPEL
Journal: Annals of Internal Medicine (1976)

Comments1 September 1976Bromergocryptine and the Galactorrhea-Amenorrhea SyndromeLAURENCE E. STEMPEL, M.D.LAURENCE E. STEMPEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-401 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the May issue, Spark and associates (Ann Intern Med 84:532-537, 1976) described the successful treatment of the galactorrhea-amenorrhea syndrome with bromergocryptine. Fifteen women, including four with pituitary tumors, received the drug; galactorrhea remitted in all, and ovulatory menses resumed in 14 of the 15. Four women, two with pituitary tumors, became pregnant while taking the drug.This article is disturbing for several reasons. First, the teratogenicity of bromergocryptine has not been adequately studied. Although preliminary reports indicate that it is not teratogenic in rats or rabbits (1), relatively few women have thus far become pregnant while...References References1. ROLLANDSCHELLEKENSLEQUIN RLR: Successful treatment of galactorrhea and amenorrhea and subsequent restoration of ovarian function by a new ergot alkaloid 2-Brom-α-ergocryptine. Clin Endocrinol 3:155-165, 1974 CrossrefMedlineGoogle Scholar2. CORRODIFUXEHÖKFELT HKT: Effect of ergot drugs on central catecholamine neurons: evidence for a stimulation of central dopamine neurons. J Pharm Pharmacol 25:409-412, 1973 CrossrefMedlineGoogle Scholar3. DEL POZOVARGAWYSS ELH: Clinical and hormonal response to bromocriptin (CB-154) in the galactorrhea syndromes. J Clin Endocrinol Metab 39:18-26, 1974 CrossrefMedlineGoogle Scholar4. CARMEL P: Neurologic surgery in pregnancy, in Surgical Disease in Pregnancy, edited by BARBER HRK, GRABER EA. Philadelphia, W. B. Saunders Co., 1974, pp. 208-209 Google Scholar5. ENOKSSONLUNDBERGSJÖSTEDT PNS: Influence of pregnancy on visual fields in suprasellar tumours. Acta Psychiatr Neurol Scand 36:524-538, 1961 CrossrefGoogle Scholar6. SPEROFFGLASSKASE LRN: Clinical Gynecologic Endocrinology and Infertility. Baltimore, The Williams and Wilkins Co., 1973, p. 108 Google Scholar7. HEKMATPANAH J: Pituitary tumors. Surg Clin North Am 49:163-178, 1969 CrossrefMedlineGoogle Scholar8. SHEARMANTURTLE RJ: Secondary amenorrhea with inappropriate lactation. Am J Obstet Gynecol 106:818-827, 1970 CrossrefMedlineGoogle Scholar1. SANDOZ CF Pharmaceuticals: Personal communication Google Scholar2. KAJTARTOMKIN TG: Emergency hypophysectomy in pregnancy after induction of ovulation. Br Med J 4:88-90, 1971 CrossrefMedlineGoogle Scholar3. SWYERLITTLEHARRIES GVB: Visual disturbance in pregnancy after induction of ovulation. Br Med J 4:90-91, 1971 CrossrefMedlineGoogle Scholar4. GEMZELL C: Induction of ovulation in infertile women with pituitary tumors. Am J Obstet Gynecol 121:311-315, 1975 CrossrefMedlineGoogle Scholar5. THORNERBESSERJONES MGA: Bromocriptine treatment of female infertility: report of 13 pregnancies. Br Med J 4:694-697, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAURENCE E. STEMPEL, M.D.Affiliations: 1490 Slade Avenue Columbus, OH 43220 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe safety of bromocriptine in hyperprolactinaemic female infertility: a literature review 1 September 1976Volume 85, Issue 3Page: 401-403KeywordsDrugsPituitary tumorsPregnancyRabbits ePublished: 1 December 2008 Issue Published: 1 September 1976 PDF downloadLoading ...