tbuckley/cabot-search huggingface dataset:
Posterior Embryotoxon in Cholestasis of Infancy
Authors: O. BERNARD
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 March 1981Posterior Embryotoxon in Cholestasis of InfancyO. BERNARD, M.D., Y. BOKOBZA, M.D.O. BERNARD, M.D.Search for more papers by this author, Y. BOKOBZA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-3-416_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent issue Riely and associates (1) reported the presence of a posterior embryotoxon in five adults and children presenting with the "syndromatic" type of paucity of interlobular bile ducts or arteriohepatic dysplasia (2). We have found this sign in 13 out of 15 children with this syndrome. Riely and associates further suggested that assessing the presence of a posterior embryotoxon could be useful in the accurate diagnosis of prolonged cholestatic jaundice in infants. We wish therefore to report our experience with slit-lamp examination in childhood cases of cholestasis.From 1 April 1980 to 1 October...References1. RIELYCOTLIERJENSENKLATSKIN CEPG. Arteriohepatic dysplasia: a benign syndrome of intrahepatic cholestasis with multiple organ involvement. Ann Intern Med. 1979;91:520-7. LinkGoogle Scholar2. ALAGILLEODIEVREGAUTIERDOMMERGUES DMMJ. Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental and sexual development and cardiac murmur. J Pediatr. 1975:86:63-71. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: O. BERNARD, M.D.; Y. BOKOBZA, M.D.Affiliations: Hôpital de Bicêtre Bicêtre France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Alagille syndrome (arteriohepatic dysplasia).ALAGILLE'S SYNDROMEXanthomas in the Watson-Aiagille syndromeArteriohepatic dysplasia: phenotypic features and family studies 1 March 1981Volume 94, Issue 3Page: 416-417KeywordsBile ductsChildrenDysplasiaInfants ePublished: 1 December 2008 Issue Published: 1 March 1981 PDF downloadLoading ...
Response to Activated Protein C and Cerebrovascular Disease
Authors: Matthew P. Jones
Journal: Annals of Internal Medicine (1997)

Letters15 May 1997Response to Activated Protein C and Cerebrovascular DiseaseMatthew P. Jones, MD and Barbara Alving, MDMatthew P. Jones, MDWalter Reed Army Medical Center, Washington, DC 20307-5001Washington Hospital Center, Washington, DC 20010Search for more papers by this author and Barbara Alving, MDWalter Reed Army Medical Center, Washington, DC 20307-5001Washington Hospital Center, Washington, DC 20010Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-10-199705150-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The most common inherited hypercoagulable state results from a mutation in factor V (factor V Leiden, 1691G → A), which causes factor Va to be “resistant” to inhibition by activated protein C (APC). This disorder is evaluated by a plasma assay that measures the ratio of the activated partial thromboplastin time with and without APC or by DNA analysis for the single point mutation of the factor V gene. A major goal of hemostasis laboratories has been to develop a plasma assay for resistance to APC that is sensitive and specific for factor V Leiden, as assessed ...References1. Dahlback B. Factor V: Q506 and a negative APC-resistance test: Modified APC-resistance test offers increased sensitivity and specificity for the FV:Q506 allele [Letter]. Thromb Haemost. 1995; 74:1380-1. Google Scholar2. Trossaert M, Conard J, Horellou MH, Elalamy I, Samama MM. The modified APC resistance test in the presence of factor V deficient plasma can be used in patients without oral anticoagulant [Letter]. Thromb Haemost. 1996; 75:521-2. Google Scholar3. van der Bom JG, Bots ML, Haverkate F, Slagboom E, Meijer P, de Jong PT, et al. Reduced response to activated protein C is associated with increased risk for cerebrovascular disease. Ann Intern Med. 1996; 125:265-9. Google Scholar4. Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med. 1995; 332:912-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Matthew P. Jones, MD; Barbara Alving, MDAffiliations: Walter Reed Army Medical Center, Washington, DC 20307-5001Washington Hospital Center, Washington, DC 20010 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1997Volume 126, Issue 10Page: 832-833KeywordsAtrial premature contractionBlood plasmaCerebrovascular diseasesFactor V LeidenMyocardial infarctionPartial thromboplastin timePoint mutationProteinsReproducibilitySpecificity ePublished: 15 August 2000 Issue Published: 15 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Transsphenoidal Microsurgery for Cushing Disease
Authors: Thomas J. Mampalam
Journal: Annals of Internal Medicine (1988)

We report cumulative results of the transsphenoidal microsurgical treatment of Cushing disease in 221 patients: 173 patients had selective adenomectomy, 25 had total hypophysectomy, 6 had partial hypophysectomy, and 12 had exploration only. Five patients were excluded from analysis because intraoperative technical difficulties precluded exposure of the pituitary gland. The selection of candidates for transsphenoidal exploration was based on endocrinologic criteria. Magnetic resonance imaging was the preferred radiologic test. Selective venous sampling of adrenocorticotropic hormone further refined the diagnosis when endocrinologic and radiologic procedures were not definitive. Remission of disease was achieved in 164 of 216 (76%) patients analyzed (95% CI, 69 to 81). Among patients with histologic confirmation of adenomas, the percentage having remission was significantly higher (P < 0.001) in patients with microadenomas than in patients with macroadenomas and in patients with intrasellar adenomas than in patients with extrasellar extension of their adenoma or perforation of the sellar floor by adenoma (P < 0.001). Five patients had an ectopic source of adrenocorticotropic hormone secretion. Two patients had diffuse pituitary hyperplasia. Complications occurred in 9.3% of the patients, including two deaths that were apparently unrelated to surgery (CI, 5.4 to 13). The results indicate that transsphenoidal surgery is the preferred treatment for most patients with Cushing disease.
Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells.
Authors: T J Braciale, K L Yap
Journal: The Journal of Experimental Medicine (1978)

This report examines the requirement for infectious virus in the induction of influenza virus-specific cytotoxic T cells. Infectious influenza virus was found to be highly efficient at generating both primary and secondary cytotoxic T-cell response in vivo. Inactivated influenza virus however, failed to stimulate a detectable cytotoxic T-cell response in vivo even at immunizing doses 10(5)-10(6)-fold higher than the minimum stimulatory dose of infectious virus. Likewise inactivated virus failed to sensitize target cells for T cell-mediated lysis in vitro but could stimulate a specific cytotoxic response from primed cells in vitro. Possible requirements for the induction of virus-specific cytotoxic T-cell responses are discussed in light of these observations and those of other investigators.
Quality of Care in Patients With Chronic Hepatitis C Virus Infection
Authors: Don C. Rockey
Journal: Annals of Internal Medicine (2011)

Letters1 February 2011Quality of Care in Patients With Chronic Hepatitis C Virus InfectionDon C. Rockey, MDDon C. Rockey, MDFrom University of Texas Southwestern Medical Center, Dallas, TX 75390.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-3-201102010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest Kanwal and colleagues' article (1) about quality of care of patients with chronic hepatitis C virus (HCV) infection. An important issue that they did not address in the treatment-related care quality indicator score was whether patients were appropriate candidates for treatment in the first place. The administrative data set used in the article is not likely to provide this information, although it is fundamental to the issue being addressed.Experienced practitioners deal with various issues in patients with chronic HCV infection and readily recognize that many patients have absolute or relative contraindications to ...References1. Kanwal F, Schnitzler MS, Bacon BR, Hoang T, Buchanan PM, Asch SM. Quality of care in patients with chronic hepatitis C virus infection: a cohort study. Ann Intern Med. 2010;153:231-9. [PMID: 20713791] LinkGoogle Scholar2. Bini E, Brau N, Ho S, Johnson D, Rossi SJ, Jeffers L. Current HCV therapies do not meet the needs of the majority of US veterans. Hepatology. 2001;34:A420. Google Scholar Author, Article, and Disclosure InformationAuthors: Don C. Rockey, MDAffiliations: From University of Texas Southwestern Medical Center, Dallas, TX 75390.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoQuality of Care in Patients With Chronic Hepatitis C Virus Infection Fasiha Kanwal , Mark S. Schnitzler , Bruce R. Bacon , Tuyen Hoang , Paula M. Buchanan , and Steven M. Asch Quality of Care in Patients With Chronic Hepatitis C Virus Infection Andrew H. Talal , David C. Perlman , and Don C. Des Jarlais Quality of Care in Patients With Chronic Hepatitis C Virus Infection Fasiha Kanwal , Bruce R. Bacon , and Steven M. Asch Metrics Cited byTree-based Claims Algorithm for Measuring Pretreatment Quality of Care in Medicare Disabled Hepatitis C Patients 1 February 2011Volume 154, Issue 3Page: 213KeywordsAntiviral therapyChronic hepatitis CConflicts of interestHealth care qualityInfectious hepatitisPatientsQuality indicatorsRNA ePublished: 1 February 2011 Issue Published: 1 February 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis
Authors: H. Sigmundsdottir, J.E. Gudjonsson, H. Valdimarsson
Journal: British Journal of Dermatology (2003)

Summary Background T lymphocytes are believed to play a role in the pathogenesis of psoriasis; > 80% of T lymphocytes that infiltrate psoriatic lesions express the surface glycoprotein cutaneous lymphocyte‐associated antigen (CLA), compared with < 20% in the blood. Exposure to ultraviolet (UV) B is an effective treatment for psoriasis. Objectives To compare the effects of UVB treatment of psoriasis on the expression of CLA and several other surface markers expressed by circulating T lymphocytes. Methods Peripheral blood mononuclear cells from psoriatic patients were stained for adhesion molecules and stimulated with streptococcal antigens before and once weekly during 3 weeks of UVB treatment. Results A marked and progressive decrease was observed during the treatment in expression of the CLA and the very late antigen‐4α by T cells; this decrease correlated closely with clinical improvement (Psoriasis Area and Severity Index). T‐cell expression of intercellular adhesion molecule‐1 was not significantly affected during the treatment and no change was observed in the activation markers CD25 and CD69 or lymphocyte proliferation after stimulation with streptococcal antigens or superantigens. Conclusions UVB treatment is associated with a marked reduction in the expression of skin‐homing molecules by circulating T cells. This may be relevant to the therapeutic effect of UVB in psoriasis.
Induction of neonatal tolerance by plasmid DNA vaccination of mice.
Authors: G Mor, G Yamshchikov, M Sedegah, M Takeno, R Wang, R A Houghten, S Hoffman, D M Klinman
Journal: Journal of Clinical Investigation (1996)

Plasmid DNA vaccines capable of preventing viral, bacterial, and parasitic infections are currently under development. Our labs have shown that a plasmid DNA vaccine encoding the circumsporozoite protein of the malaria parasite elicits protective immunity against live sporozoite challenge in adult BALB/c mice. We now find that the same DNA vaccine induces tolerance rather than immunity when administered to 2-5 d-old mice. Neonatally tolerized animals were unable to mount antibody, cytokine or cytotoxic responses when rechallenged with DNA vaccine in vitro or in vivo. Tolerance was specific for immunogenic epitopes expressed by the vaccine-encoded, endogenously produced antigen. Mice challenged with exogenous circumsporozoite protein produced antibodies against a different set of epitopes, and were not tolerized. These findings demonstrate important differences in the nature and specificity of the immune response elicited by DNA vaccines versus conventional protein immunogens.
Recovery after Coma
Authors: FRED PLUM
Journal: Annals of Internal Medicine (1976)

Comments and Correction1 August 1976Recovery after ComaFRED PLUM, M.D.FRED PLUM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-2-263_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Anecdotal but medically undocumented reports intermittently appear about good neurologic and mental recovery after prolonged coma due to cerebral anoxic-ischemic injury or head trauma. We are investigating such cases because of their profound humane and medicolegal implications, and we would appreciate hearing from physicians who know directly of such patients. We shall arrange to obtain necessary additional information in appropriate instances.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Neurology New York Hospital 525 East 68th Street New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1976Volume 85, Issue 2Page: 263-263KeywordsComaHead injuryHearing Issue Published: 1 August 1976 PDF DownloadLoading ...
Cat-scratch Fever
Authors: T. A. Brand, K. C. Finkel
Journal: BMJ (1956)

MULTIPLE MYELOMATOSISMEDICALSJOURNAL of all doubtful cases.A significant degree of anaemia is a usual finding in myelomatosis, but is rarely seen in uncomplicated cases of hyperparathyroidism. SummaryA case of multiple myelomatosis presenting with a spontaneous fracture is described.Hypercalcaemia, hypercalcuria, normal serum phosphorus in the presence of severe impairment of renal function, and an elevated urinary clearance of phosphate led to the diagnosis of hyperparathyroidism.The parathyroid glands were found to be normal, and at necropsy myelomatous replacement of two vertebral bodies, invasion of liver sinusoids, and myeloma kidney were found.This condition resembles hyperparathyroidism in that there may be an increased urinary excretion of phos- phate as well as hypercalcaemia and hypercalcuria.The possible causes of the hypercalcaemia are discussed.The differential diagnosis between multiple myelomatosis and hyperparathyroidism is considered.The most important point would appear to be to remember how closely the two diseases may resemble each other.Our thanks are due to Mr. Ian Fraser, who referred the patient to one of us (D.A. D. M.) and who, with Mr. E. Morrison, operated on the patient.The advice
Secator: A Program for Inferring Protein Subfamilies from Phylogenetic Trees
Authors: Nicolas Wicker, Guy René Perrin, Jean Claude Thierry, Olivier Poch
Journal: Molecular Biology and Evolution (2001)

With the huge increase of protein data, an important problem is to estimate, within a large protein family, the number of sensible subsets for subsequent in-depth structural, functional, and evolutionary analyses. To tackle this problem, we developed a new program, Secator, which implements the principle of an ascending hierarchical method using a distance matrix based on a multiple alignment of protein sequences. Dissimilarity values assigned to the nodes of a deduced phylogenetic tree are partitioned by a new stopping rule introduced to automatically determine the significant dissimilarity values. The quality of the clusters obtained by Secator is verified by a separate Jackknife study. The method is demonstrated on 24 large protein families covering a wide spectrum of structural and sequence conservation and its usefulness and accuracy with real biological data is illustrated on two well-studied protein families (the Sm proteins and the nuclear receptors).
THE INJECTION TREATMENT OF TUBERCULOUS JOINTS
Authors: LEONARD W. ELY
Journal: JAMA (1913)

The treatment of all joint diseases, whatever their cause, seems to follow certain well-defined lines and in rather definite order. The first and second expedients resorted to are external applications and internal medication. If these fail we turn to the third, incision and drainage. This appears logical. If a joint is swollen, painful and inflamed, we infer that there must be something inside that is causing the trouble, and that if we let this something out the disease will heal. Failing here in our efforts we resort to the fourth, aspiration and injection. Here again we seem to be on safe ground. If we can withdraw from the joint cavity the products of disease and then can inject some beneficent substance, we shall be able to cure the disease. If by any chance, after trying all these methods of cure, we have not found the specific sought for, we are
Abstract 13457: The Relation of Physical Activity With Accelerometry and Adipose Tissue Depots in a Community-Based Sample of Adults: The Framingham Third Generation Cohort
Authors: Joanne M Murabito, Alison Pedley, Joseph M Massaro, Ramachandran S Vasan, Nicole L Glazer, Udo Hoffman, Caroline S Fox
Journal: Circulation (2011)

Background: Physical inactivity is an important factor leading to obesity. We examined the relation between objectively measured physical activity by accelerometry and subcutaneous adipose tissue (...
Cancer guidelines from NICE aim to reduce variation in referral times
Authors: Zosia Kmietowicz
Journal: BMJ (2005)

New guidelines on referring patients with suspected cancer in England and Wales have been launched by the National Institute for Health and Clinical Excellence (NICE). Professor Peter Littlejohns, clinical and public health director at NICE and executive lead for the guidelines, said that the document “will help to ensure that people wherever they live in England and Wales, who present in primary care with suspected cancer will benefit from a consistent and coherent approach which is based on the best available evidence.”

The guidelines update previous recommendations from the Department of Health published in 2000, taking account of new evidence from research and from audits. They make recommendations on the diagnostic and referral process for the …
The Majority of H2-M3 Is Retained Intracellularly in a Peptide-Receptive State and Traffics to the Cell Surface in the Presence of <i>N</i>-Formylated Peptides
Authors: Nancy M. Chiu, Taehoon Chun, Miriam Fay, Manas Mandal, Chyung-Ru Wang
Journal: The Journal of Experimental Medicine (1999)

We used a new monoclonal antibody (mAb 130) to analyze the intracellular trafficking and surface expression of H2-M3, the major histocompatibility complex class Ib molecule that presents N-formylated peptides to cytotoxic T cells. M3 surface expression is undetectable in most cell types due to the paucity of endogenous antigen. M3 is induced on the cell surface by addition of high-affinity N-formylated peptides from mitochondria and listeria. Peptide-induced M3 expression is most efficient on antigen presenting cells. Basal and inducible expression of M3 is transporter associated with antigen processing (TAP)-dependent, distinguishing M3 from the class Ib molecules TL and CD1. Unlike the expression of class Ia molecules and a previously described M3/Ld chimera, surface expression of M3 cannot be rescued by lowered temperature, suggesting that the α3 domain and transmembrane region of M3 may control trafficking. Pulse–chase analysis and use of trafficking inhibitors revealed a pool of empty M3 in the endoplasmic reticulum or early Golgi apparatus. Addition of exogenous peptide allows maturation with kinetics matching those of Dd. The lack of endogenous N-formylated peptide allows discovery of novel pathogen-derived peptides in normal antigen presenting cells. The nonpolymorphic nature of M3 and its ability to present bacterial antigens rapidly and dominantly make it an attractive target for peptide vaccination strategies.
Second-Day Encephalography, with Particular Reference to the Size of the Ventricles
Authors: Richard Schatzki, Donald H. Baxter, Charles E. Troland
Journal: New England Journal of Medicine (1947)

THE literature contains a comparatively small number of publications concerning the appearance of the ventricles on the days following encephalography, although it is quite probable that a number of investigators have been interested in such follow-up studies without publishing them. Of the published reports, some were confined to the rate of absorption of air after encephalography,1 , 2 whereas others emphasized the importance of second-day studies for the demonstration of porencephalic cysts.3 , 4 Only a few observations were concerned with the size of the ventricles during follow-up studies, and those were quite contradictory. Schott and Eitel,5 as well as Reinberg,6 mention dilatation of . . .
Neutron activation analysis of trace elements in skin.
Authors: ANAT MOLOKHIA, BENJAMIN PORTNOY, ALAN DYER
Journal: British Journal of Dermatology (1979)

Selenium(Se) has been determined in skin by neutron activation analysis applying selective irradiation and cooling time, followed by measurement of the activity on a high resolution germanium lithium (Ge(Li)) detector. The levels and distribution of Se in normal abdominal and plantar skin, together with other available evidence, lead us to believe that it is an essential trace element in man. It is suggested that Se has an essential role in skin keratinization.
Every package needs a government health warning
Authors: T. Greenhalgh
Journal: BMJ (1996)

She lives in a nice house in a smart part of town. When she comes to see me she wears high boots and a coat with a mink collar and sits primly in the waiting room reading Country Life. She and I have two secrets. One is her age (mid-90s) and the other her income (none but her state pension). The house and coat were bought before she was widowed in the war, and she reads my magazines because she cannot afford her own.

She presented with a stiff neck (wear and tear, no doubt), so I referred her for physiotherapy. …
Transfusion therapy for erythropoietic protoporphyria
Authors: A. DOBOZY, M. CSATO, C. SIKLOSI, N. SIMON
Journal: British Journal of Dermatology (1983)

Five patients with erythropoietic protoporphyria, in whom beta-carotene treatment had proved unsuccessful, were treated on 5 or 6 occasions with washed, packed red blood cell transfusions. Following the transfusions, the photosensitivity and the protoporphyrin levels in the red blood cells decreased considerably. This treatment may be useful in reducing the high protoporphyrin level in patients with a rapidly deteriorating hepatic function.