tbuckley/cabot-search huggingface dataset:
Quality Comes Home
Authors: Michael D. Cantor
Journal: Annals of Internal Medicine (1997)

Letters15 May 1997Quality Comes HomeMichael D. Cantor, MD, JDMichael D. Cantor, MD, JDHebrew Rehabilitation Center for Aged, Boston, MA 02131Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-10-199705150-00041 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:One of the most difficult tasks we face is improving the quality of health care for the elderly. Dr. Berwick's account of his father's illness [1] is an unfortunately common story of poor care of an older person. Geriatric syndromes such as polypharmacy, decubiti, and delirium are treatable and avoidable, and their ubiquity demonstrates that more attention should be paid to the special needs of the elderly.First, we need to emphasize continuity of care. One way to achieve the “integration of experience” Dr. Berwick recommends is to use multidisciplinary teams that provide services across the spectrum ...References1. Berwick DM. Quality comes home. Ann Intern Med. 1996; 125:839-43. Google Scholar2. Reinhardt UE. Spending more through ‘cost control’: our obsessive quest to gut the hospital. Health Aff (Milwood). 1996; 15:145-54. Google Scholar Author, Article, and Disclosure InformationAuthors: Michael D. Cantor, MD, JDAffiliations: Hebrew Rehabilitation Center for Aged, Boston, MA 02131 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1997Volume 126, Issue 10Page: 835KeywordsDeliriumElderlyGeriatricsHealth care qualityLong-term careMedicareParkinson disease ePublished: 15 August 2000 Issue Published: 15 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
TCT-230 Impact of Delay to reperfusion on Infarct Size and Clinical Outcomes in Patients with STEMI: The INFUSE-AMI Trial
Authors: Alejandra Guerchicoff, Sorin Brener, Martin Fahy, C. Michael Gibson, Akiko Maehara, Roxana Mehran, Gregg Stone, Bernhard Witzenbichler
Journal: Journal of the American College of Cardiology (2013)
Computerized Three-Dimensional Localization of Prostate Cancer Using Contrast-Enhanced Power Doppler and Clustering Analysis
Authors: Hilco van Moerkerk, Stijn W.T.P.J. Heijmink, Christina A. Hulsbergen-v.d. Kaa, Jelle O. Barentsz, J. Alfred Witjes
Journal: European Urology (2006)
A specific linkage between the incidence of <i>TP53</i> mutations and type of chromosomal translocations in B‐precursor acute lymphoblastic leukemia cell lines
Authors: Takeshi Inukai, Xiuru Zhang, Takeshi Kameyama, Yukiko Suzuki, Kazuhito Yoshikawa, Itaru Kuroda, Atsushi Nemoto, Koshi Akahane, Hiroki Sato, Kumiko Goi, Kazunori Nakamoto, Jun‐ichi Hamada, Mitsuhiro Tada, Tetsuya Moriuchi, Kanji Sugita
Journal: American Journal of Hematology (2010)

CIBMTR) held their 12th Annual Tandem Meeting this February in Orlando, Florida.This International Transplant Meeting brought together a record 2,570 attendees from 45 countries, and included the state of the art educational and plenary sessions and 478 oral and poster presentations.Recently, the American Journal of Hematology published a series of articles reviewing the ''Top 10 clinically oriented abstracts'' presented at the 2009 American Society of Hematology meeting [1].Given how well this series was received, we believed it would be worthwhile providing a similar review of relevant abstracts from this year's BMT meetings.There has been dramatic progress in this field that we believe is of great interest and importance to the hematology/oncology community.There was an incredible body of work presented and it is misleading to suggest that there is a ''top 10'' list.Many more abstracts than can be presented here are worthy of discussion and recognition and any exclusion of important studies is solely a reflection of space limitation rather than quality of work.We tried to pick abstracts that were important, novel, biologically interesting, and that address either changing or controversial areas in the field.All 10 abstracts are published in full in the February 2010 issue of Biology of Blood and Marrow Transplantation (volume 16, No. 2) and are identified here by their abstract number.Frequency of CD4 1 CD25 hi FOXP3 1 Regulatory T Cells Has Diagnostic and Prognostic Value As a Biomarker for Acute Graft-Versus-Host-Disease (#5)
Influence of glutathione S-transferase B (ligandin) on the intermembrane transfer of bilirubin. Implications for the intracellular transport of nonsubstrate ligands in hepatocytes.
Authors: S D Zucker, W Goessling, B J Ransil, J L Gollan
Journal: Journal of Clinical Investigation (1995)

To examine the hypothesis that glutathione S-transferases (GST) play an important role in the hepatocellular transport of hydrophobic organic anions, the kinetics of the spontaneous transfer of unconjugated bilirubin between membrane vesicles and rat liver glutathione S-transferase B (ligandin) was studied, using stopped-flow fluorometry. Bilirubin transfer from glutathione S-transferase B to phosphatidylcholine vesicles was best described by a single exponential function, with a rate constant of 8.0 +/- 0.7 s-1 (+/- SD) at 25 degrees C. The variations in transfer rate with respect to acceptor phospholipid concentration provide strong evidence for aqueous diffusion of free bilirubin. This finding was verified using rhodamine-labeled microsomal membranes as acceptors. Bilirubin transfer from phospholipid vesicles to GST also exhibited diffusional kinetics. Thermodynamic parameters for bilirubin dissociation from GST were similar to those for human serum albumin. The rate of bilirubin transfer from rat liver basolateral plasma membranes to acceptor vesicles in the presence of glutathione S-transferase B declined asymptotically with increasing GST concentration. These data suggest that glutathione S-transferase B does not function as an intracellular bilirubin transporter, although expression of this protein may serve to regulate the delivery of bilirubin, and other nonsubstrate ligands, to sites of metabolism within the cell.
Christian Scientists Claim Healing Efficacy Equal If Not Superior to That of Medicine
Authors: Andrew Skolnick
Journal: JAMA (1990)

IN THE WAKE of convictions of parents for what has been called the religiously motivated medical neglect of their children, the Christian Science Church is trying to persuade state legislatures that its particular form of healing by prayer is as least as effective as medicine. Child protection advocates suggest that this new "more secular strategy" is in response to the recent failure of some religious exemption statutes to protect church members from prosecution when their children die from medical neglect. While the church claims religious exemptions from provisions of child abuse and neglect laws are a First Amendment right, courts consistently have ruled that religious freedom does not allow parents to withhold life-saving medical care from children (<i>The Law's Response When Religious Beliefs Against Medical Care Impact on Children</i>. Sioux City, Iowa: CHILD, Inc; 1990). In the meantime, legislation recently adopted in Colorado, Texas, and Louisiana, and under consideration elsewhere,
Neck movements in ankylosing spondylitis and their responses to physiotherapy.
Authors: S L O'Driscoll, M I Jayson, H Baddeley
Journal: Annals of the Rheumatic Diseases (1978)

Cervical spine movements were compared in 35 patients with ankylosing spondylitis (AS) and matched controls. In AS there were limitations of all movements and particularly of lateral flexion. These limitations could not be correlated with any particular features of AS except radiological involvement of the lower apophyseal joints. In 25 patients there were significant improvements in all measurements after 3 weeks of intensive inpatient physiotherapy. After discharge the patients were encouraged to perform unsupervised physiotherapy and in 11 patients seen at 3 months the improvements in neck movements were either maintained or increased further. In contrast no changes in movements were found in 9 patients assessed 3 weeks and immediately before starting physiotherapy.
Ambulation in labour.
Authors: A M Flynn, J Kelly, G Hollins, P F Lynch
Journal: BMJ (1978)

In a randomised prospective study of 68 women in spontaneous labour half were allocated to an ambulant group and half to a recumbent group. The duration of labour was significantly shorter, the need for analgesia significantly less, and the incidence of fetal heart abnormalities significantly smaller in the ambulant group than in the recumbent group. Apgar scores at one and five minutes were also significantly greater in the ambulant group. More patients in the recumbent group required augmentations with oxytocic drugs. There was no statistically significant difference in the third stage loss in the two groups. Ambulation in labour should be encouraged: it may bring human benefits while allowing the advantages of hospital supervision.
F-18 FDG-PET Imaging in Adult T-Cell Leukemia Lymphoma
Authors: Naoto Watanabe, Jun Murakami, Keisuke Kameda, Hiroshi Kato, Yuichi Kamisaki, Kyo Noguchi, Hisashi Funada, Hikaru Seto
Journal: Clinical Nuclear Medicine (2008)

Adult T-cell leukemia lymphoma is extremely rare. We report a case of adult T-cell leukemia lymphoma involving lymph nodes and the liver. F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) imaging is a useful modality in detecting various tumors, including malignant lymphoma. We evaluated a patient with adult T-cell leukemia lymphoma using F-18 FDG PET imaging, which detected abnormal increased uptake in the left submandibular area, neck, clavicular area, axilla, mediastinum, liver, abdomen, and groin. The standardized uptake value of the highest FDG uptake was 20.5.
Diabetes and Nonrefractive Visual Impairment
Authors: David C. Musch, Thomas W. Gardner
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fantus Estimation of Urinary Chloride
Authors: H. L. Marriott
Journal: BMJ (1951)

BDIuTsoNAExploration was carried out, and the findings were those so well described, the rectus sheath having been ruptured.The deep epigastric vessels were intact, but it was seen that there were some small muscular branches still bleeding, and these were transfixed.The rupture had occurred high up in the rectus at the junction of the upper one-third and lower two-thirds.A clot was taken out, the rectus sheath sutured, and a drain left in the cavity.The wound took some time to heal, but eventually did so satisfactorily.
FUNGOUS INFECTIONS OF THE HANDS AND FEET
Authors: R. Hallam
Journal: BMJ (1928)

IMMUNIZATION AGAINST MEASLES.[MTRz:"iA& 835 institutiolns which 'for years previously lhad been com- pletely free from this disease, probably owing to the fact that most oif the children are recruited from unaffected rural districts, we found that immunity was practically non-existent.And so, unfortunately, the building up of a sufficient degree of immunity prov-ed a matter of no little difficulty, requiring indeed, as eventually became evident, a time interval more lengthy than previously observed.It remains to be seen whether the response to immunization work in scarlet fever will be found to run on similar lines.It is, I think, as yet hardly possible to estimate what may eventually p'rove to be its precise value as compared with
Specialised multidisciplinary team can solve problems of distance
Authors: A. Cabre, K. P Gibbin, M. Henley, R. N Nashed
Journal: BMJ (1995)

Editorial proves controversialED1ToR,-In their two year Medline search for studies on the results of cleft surgery Tony Markus and Peter Ward Booth found just one British study, and they criticise the lack of British studies.'Six studies on primary and secondary surgery and outcome analysis are noteworthy,2-7 as is a book on speech.8Citing just the Eurocleft study, which included two British centres, Markus and Ward Booth state that British results are poor.This is not true in other British studies.910The authors neglect to mention that the two centres with the best results in the Eurocleft study used different surgical techniques (none like Markus's) and high volume operators (none of them maxillofacial surgeons).On high volume operators Markus and Ward Booth are incoherent.They move from implying that specialist high volume operators are preferable to stating that high volume operators and large, centralised units do not guarantee good results, while high volume maxillofacial surgery exists in district hospitals, which are well placed to provide a comprehensive service.European countries, including Britain, have made advances in cleft surgery."Continental Europe may do it better"'-or it may not.Early cleft bone grafting was once strongly advocated in Germany, but further studies in, for example, Britain and Germany led to its being abandoned."For years the technique of delayed hard palate closure of Schweckendiek in Germany was considered to be good, until it was reported to give poor results in terms of speech.'2Other studiesfor example, one in Britain-had earlier shown worse speech after delayed hard palate closure.'2Two French cleft surgeons, Malek and Delaire, are known internationally.Delaire never kept detailed records and did not publish his results.Nevertheless, Markus uses Delaire's technique and states that it "results in better function and more normal growth and development."'There is no evidence for this in the references given.Markus labels his surgery functional surgery, as
New translocation involving homologous chromosome 3 in acute myelogenous leukemia (M2)
Authors: R S Verma, M da Costa, S K Gogineni, G Palermo
Journal: American Journal of Hematology (1993)

An apparent balanced translocation involving the long arms of homologous chromosomes is described for the first time in a patient with acute myelogenous leukemia (AML) (M2), i.e., 46,XY,t(3;3) (q21;q26). After reviewing the literature, it was noted that a breakpoint involving band 3q26 is a frequent anomaly in other translocations. Thus, we are tempted to hypothesize that 3q26 band may also play an important role in the pathogenesis of AML (M2).
TGF-β1 + EGF-Initiated Invasive Potential in Transformed Human Keratinocytes Is Coupled to a Plasmin/MMP-10/MMP-1–Dependent Collagen Remodeling Axis: Role for PAI-1
Authors: Cynthia E. Wilkins-Port, Qunhui Ye, Joseph E. Mazurkiewicz, Paul J. Higgins
Journal: Cancer Research (2009)

The phenotypic switching called epithelial-to-mesenchymal transition is frequently associated with epithelial tumor cell progression from a comparatively benign to an aggressive, invasive malignancy. Coincident with the emergence of such cellular plasticity is an altered response to transforming growth factor-beta (TGF-beta) as well as epidermal growth factor (EGF) receptor amplification. TGF-beta in the tumor microenvironment promotes invasive traits largely through reprogramming gene expression, which paradoxically supports matrix-disruptive as well as stabilizing processes. ras-transformed HaCaT II-4 keratinocytes undergo phenotypic changes typical of epithelial-to-mesenchymal transition, acquire a collagenolytic phenotype, and effectively invade collagen type 1 gels as a consequence of TGF-beta1 + EGF stimulation in a three-dimensional physiologically relevant model system that monitors collagen remodeling. Enhanced collagen degradation was coupled to a significant increase in matrix metalloproteinase (MMP)-10 expression and involved a proteolytic axis composed of plasmin, MMP-10, and MMP-1. Neutralization of any one component in this cascade inhibited collagen gel lysis. Similarly, addition of plasminogen activator inhibitor type 1 (SERPINE1) blocked collagen degradation as well as the conversion of both proMMP-10 and proMMP-1 to their catalytically active forms. This study therefore identifies an important mechanism in TGF-beta1 + EGF-initiated collagen remodeling by transformed human keratinocytes and proposes a crucial upstream role for plasminogen activator inhibitor type 1-dependent regulation in this event.
Correction of Dilutional Hyponatremia in Severe Chronic Heart Failure by Converting-Enzyme Inhibition
Authors: Milton Packer, Norma Medina, Madeline Yushak
Journal: Annals of Internal Medicine (1984)

To determine the effects of vasodilator and inotropic therapy on hyponatremia in patients with severe heart failure, we measured serum sodium concentration before and after treatment with captopril (70 patients), hydralazine (42 patients), prazosin (22 patients), and amrinone (19 patients), while diuretic dosages were kept constant. Serum sodium concentration increased only in hyponatremic patients treated with captopril (131.2 +/- 0.5 to 135.9 +/- 0. 5 SE ; p less than 0.001), but not during therapy with the other agents and not in patients with normal serum sodium concentration before treatment. Serum sodium began to rise 48 hours after the initiation of captopril therapy and reached its peak after 14 to 16 days. Correction of hyponatremia was related to functional interference with the renin-angiotensin system, but not to changes in renal function, serum potassium concentration, body weight, or the magnitude of hemodynamic or clinical improvement. These findings support experimental evidence that the renin-angiotensin system is important in the pathogenesis of hyponatremia in patients with severe heart failure treated with diuretics.
England gets five academic health science centres to compete on global stage
Authors: Z. Kmietowicz
Journal: BMJ (2009)

The health secretary, Alan Johnson, announced on 9 March that five academic health science centres are to be created in England, after peer review of the seven final applicants by an international panel of experts.

The successful centres are Cambridge University Health Partners, Imperial College, King’s Health Partners, Manchester AHSC, and University College London Partners. Bids from Oxford and Birmingham were unsuccessful.

In July 2007 the junior health minister Ara Darzi had called for …
Brain Scan Artifact From Saliva Contamination
Authors: N. H. Engbring
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The ready availability of technetium 99m for brain scanning recently has promoted its wider use in clinical medicine. The advantages of using this isotope are well known; however, certain disadvantages may not be appreciated. One of these disadvantages has been pointed out by Witcofski et al<sup>1</sup>and bears emphasis since it is a potential source of confusion or misdiagnosis. This is the artifact observed when there is extracranial contamination with saliva. <h3>Report of a Case:</h3> A 75-year-old woman who was comatose and hemiplegic because of a presumed cerebrovascular accident was referred for brain scan. She was given 7.7 mc of technetium 99m in the pertechnetate form (obtained from a sterile generator) intravenously. Scanning was begun one hour later and progressed from anterior to left lateral to right lateral views (Fig 1). Although there were no apparent abnormalities on the first two views, an area of intense
New findings concerning ventricular septation in the human heart. Implications for maldevelopment.
Authors: W H Lamers, A Wessels, F J Verbeek, A F Moorman, S Virágh, A C Wenink, A C Gittenberger-de Groot, R H Anderson
Journal: Circulation (1992)

BACKGROUND The mechanics involved in development of the inlet component of the morphologically right ventricle are, as yet, undecided. Some argue that this component is derived from the descending limb of the ventricular loop, and that the inlet and apical trabecular components of the muscular ventricular septum have separate developmental origins. Others state that the entirety of the right ventricle grows from the ascending limb of the loop, and that the muscular septum, apart from its outer component, has a unitary origin. We now have material from human embryos at our disposal, which, we believe, solves this conundrum. METHODS AND RESULTS We used a monoclonal antibody against an antigen to neural tissue from the chick to demarcate a ring of cells separating the descending (inlet) and ascending (outlet) limbs of the developing ventricular loop of the human heart. Preparation of serial sections of graded human embryos enabled us to trace the fate of this ring, and hence the formation of the inlet of the right ventricle, to the completion of cardiac septation. Eight embryos were studied, encompassing stages 14-23 of the Carnegie classification. The ring of cells initially separating the ascending and descending limbs of the ventricular loop were, at the conclusion of ventricular septation, located within the atrioventricular junction, sequestrated for the most part in the terminal segment of atrial myocardium. CONCLUSIONS Our study conclusively shows that the inlet component of the morphologically right ventricle is derived from the ascending limb of the embryonic ventricular loop, and that the inlet and apical trabecular components of the muscular septum are derived from the same primary ventricular septum.
1106-185 Growth hormone-releasing peptide can suppress myocardial oxidative stress and ameliorate progressive left ventricular remodeling in cardiomyopathic hamsters
Authors: Mitsunori Iwase, Sahoko Ichihara, Yosuke Kato, Aya Matsushita, Hiroaki Kanazawa, Katsunori Hashimoto, Koji Obata, Kohzo Nagata, Toyoaki Murohara, Mitsuhiro Yokota, Takasi Tsunematsu, Yoshihiro Ishikawa
Journal: Journal of the American College of Cardiology (2004)
The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency
Authors: Allen K. L. Cheung, David J. Gottlieb, Bodo Plachter, Sandra Pepperl-Klindworth, Selmir Avdic, Anthony L. Cunningham, Allison Abendroth, Barry Slobedman
Journal: Blood (2009)