tbuckley/cabot-search huggingface dataset:
THE POST-MORTEM STAINING OF BONE PRODUCED BY THE ANTE-MORTEM SHEDDING OF BLOOD
Authors: F. W. Jones
Journal: BMJ (1908)

POST-MORTEM BLOOD STAINS' W-iONE3.[Mna 9 28,-9.often both bones, and sometimes in both arms-has alrays-been exceedingly common in Egypt in com- prlWhrt With the incidence of other fractures.This is true of every period from the earliest known pre- hlatortk times up till the present.The Egyptians have always indtilged in fencing, both as an amusement and also as a serious method of attack; for both purposes they use the saboot, a very thick, heavy stick about 6 ft.l16g, which many Egyptian peasants habitually arry.No doubt the great majority of these fractures of the forearm were inflicted while the victim, with upraised am,was defending himself or herself; for a considerable number of women, especially in prehistoric times, have stiff6red from this injury.In the Anatomical Museum In the Citro School of Medicine there is an example of such a fraoture of the left forearm in a girl of the time of the twenty-sixth dynasty (about 600 B.O.),whosebodilyremains bear distinct traces, not only of the manner in which the injury was inflicted, but also of a possible reason for the fatAI attaok.whichhadbeen made upon her.Shewas a young woman less than 20 years of age and in the sixth month *Z."29. 3--Diagram to show the opening of the sutures at the base of the skull.(Illustrating Dr. Wood Jones's paper, p. 736.)of pregnancy; just when her condition was making itself evident she was murdered by a series of blows, one on ,the left forearm, another on the left shoulder breaking the acromion process, and others the fital blow, smashing the left side of the jaw, face, and cranium.*There Is, 'perhaps, no such common motive for murder In Egypt at the present day as the discovery by a ifather or brother of delinquency on the part of a daughter or sister.Thts ,case seem to have been an ancient instance of a drama of daily:ocuce in Egypt tooday.Thpn is-one curious feature common to both sets of
Poly(d,l-lactic acid) surfaces modified by silk fibroin: effects on the culture of osteoblast in vitro
Authors: Kaiyong Cai, Kangde Yao, Songbai Lin, Zhiming Yang, Xiuqiong Li, Huiqi Xie, Tingwu Qing, Laibao Gao
Journal: Biomaterials (2002)
Postpartum Hepatic Hemorrhage in the Syndrome of Hemolysis, Elevated Liver Enzymes, and Low Platelets: Diagnosis by Radiocolloid Scanning
Authors: HEE KYUNG LEE, JOSEPH SKARZYNSKI, ROBERTA HAYNES DE REGT, FELIX MCLYMONT
Journal: Clinical Nuclear Medicine (1988)

Three cases of postpartum hepatic hemorrhage in the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP) were diagnosed by Tc-99m sulfur colloid liver-spleen scanning. Two patients had follow-up scans. One showed rapid resolution of the hematoma on the repeat scan performed six days later, while the other showed delayed resolution on the repeat scan four weeks later. All patients received non-surgical supportive therapy with or without blood transfusion after delivery, and recovered well. Usefulness of radionuclide liver-spleen scanning in the diagnosis of peripartum hepatic hemorrhage and monitoring course of the disease is emphasized.
Pilot study of continuous co‐infusion of morphine and naloxone in children with sickle cell pain crisis
Authors: Josh Koch, Renee Manworren, Lynn Clark, Charles T. Quinn, George R. Buchanan, Zora R. Rogers
Journal: American Journal of Hematology (2008)

Patients with sickle cell disease experience painful crises that often require hospitalization for a continuous infusion of morphine that may cause significant pruritus. We conducted a pilot study to determine the feasibility of simultaneous continuous co-infusion of naloxone with morphine, test novel assessment instruments for pruritus, and explore whether pruritus could be reduced while maintaining effective analgesia. Patients with sickle cell disease and painful crisis requiring continuous infusion morphine received continuous co-infusion of naloxone at 0.25 (low dose) or 1.0 mcg/kg x hr (high dose). Pain scores were obtained using the FACES scale and a 100-mm visual analog scale (VAS). Itching was quantified by a modified VAS score. Evaluable data were obtained on 16 patients. Simultaneous co-infusion of naloxone and morphine was feasible, did not seem to reduce the analgesic efficacy of morphine, and was associated with no adverse effects. The high dose group reported a lower median "VAS worst itch" score than the low dose group (4.8 vs. 7.3, P = 0.08). Simultaneous continuous infusion of naloxone with morphine in pediatric patients with sickle cell disease and pain crisis was feasible and well tolerated. A quantitative pruritus score allowed us to systematically measure pruritus. Further evaluation by randomized, placebo-controlled study of 1 mcg/kg x hr naloxone in this setting is required.
GALLIUM-67 IMAGE CONTRAST
Authors: A. J. Kwan, R. E. Zimmerman, F. K. Keech, E. E. OʼConnor, W. D. Kaplan
Journal: Clinical Nuclear Medicine (1995)

Kwan, A. J.; Zimmerman, R. E.; Keech, F. K.; O'Connor, E. E.; Kaplan, W. D. Author Information
Idiotypic network connectivity and a possible cause of myasthenia gravis.
Authors: D S Dwyer, M Vakil, J F Kearney
Journal: The Journal of Experimental Medicine (1986)

Extensive idiotypic connectivity has been discovered between the antibodies composing the immune responses against the acetylcholine receptor (AChR) and alpha-1,3-dextran. The idiotypic connections form an elaborate network linking these disparate antigen systems, and there is an hierarchical organization of the antibodies in this network. The key anti-Ids that interconnect these two responses are more crossreactive, lower-affinity antibodies. Interestingly, 15% of patients with MG, which is caused by autoantibodies against the AChR, have serum antibodies against DEX. Control sera are negative for anti-DEX antibodies. Certain anti-DEX antibodies also bind to anti-AChR antibodies via idiotypic interactions. These findings suggest a model for the initiation of autoimmunity in MG. Antibodies made in response to DEX epitopes on the surface of certain bacteria would elicit the production of anti-Ids. However, some of these anti-Ids would also be autoantibodies against the AChR. Thus, is some circumstances, autoimmunity may develop as a consequence of the normal operation of regulatory idiotypic networks.
Microsatellite analysis in rheumatoid arthritis synovial fibroblasts
Authors: F. Kullmann
Journal: Annals of the Rheumatic Diseases (2000)

<h3>OBJECTIVES</h3> Rheumatoid arthritis (RA) is a chronic disease characterised by irreversible destruction of the affected joints. As aggressive transformed-appearing synovial fibroblasts are commonly found at the site of invasion of the rheumatoid synovium into the adjacent cartilage and bone, the presence of microsatellite instability (MSI) and expression of mismatch repair enzymes as a possible mechanism in the alteration of these cells was examined. <h3>METHODS</h3> DNA was extracted from the synovial fibroblasts and blood of 20 patients with long term RA undergoing joint replacement, and the presence of MSI was studied at 10 microsatellite loci. In addition, immunohistochemistry was performed to evaluate the expression of the two major mismatch repair enzymes (<i>hMLH1</i> and<i>hMSH2</i>) in rheumatoid synovium. <h3>RESULTS</h3> MSI could not be detected in any of the fibroblast cell populations derived from the 20 different rheumatoid synovial samples. In addition, strong expression of mismatch repair enzymes could be seen in numerous cells, including fibroblasts, throughout the synovium. <h3>CONCLUSIONS</h3> Applying the currently used and established markers for MSI, the data show for the first time that MSI does not appear to have an important role in alteration of rheumatoid synovial fibroblasts into an aggressive phenotype. On the other hand, strong mismatch repair enzyme synthesis in rheumatoid synovium supports the hypothesis of continuing DNA repair, presumably due to long term, inflammation induced DNA damage.
REPORT OF CASE OF TOTAL ADHERENT SOFT PALATE; OPERATION AND RECOVERY.Read in the Section on Laryngology and Otology, at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: J. E. SCHADLE
Journal: JAMA (1894)

Eighteen months since, James S. consulted me in reference to complete stenosis of the nasal passages and deafness which had existed for a period of seventeen years. On examination of the nasal passages they were found to contain polypoid growths varying in size, which by their presence seemed to annoy considerably the patient by creating a continuous flow of serous fluid from the nostrils and bringing on attacks of violent sneezing, which condition ceased soon after the tumors were removed. Inspection of the throat revealed partial obliteration of the pillars of the palate, entire loss of the uvula, and total adhesion of the velum palati to the posterior wall of the pharynx. What still remained of the soft palate consisted chiefly of cicatricial tissue as was evidenced by the firmness and density of the structure. After explaining to the patient the character of his trouble, informing him of the difficulty
LONGITUDINAL 2D STRAIN IS SUPERIOR TO EF IN DETECTING MYOCARDIAL IMPAIRMENT AND POSTINTERVENTIONAL IMPROVEMENT IN CARDIAC FUNCTION IN PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Aleksander Kempny, Gerhard-Paul Diller, Gerrit Kaleschke, Gregor Kerckhoff, Stefan Orwat, Monika Anna Stenzel, Julia Mascherbauer, Holger Reinecke, Helmut Baumgartner
Journal: Journal of the American College of Cardiology (2010)
Cost of free personal care for older people in Scotland doubled in eight years
Authors: I. Torjesen
Journal: BMJ (2013)

The cost of providing free personal and nursing care to people aged 65 or over in Scotland has more than doubled in eight years, from £219m (€250m; $330m) in 2003-04 to £458m in 2011-12, figures released by the Scottish government show.1

Most of the increased spending was the result of more people receiving services in their own homes and for longer each week, which the government said showed that the policy was successfully enabling more people with complex needs to remain in their own homes for longer.

The figures show that local authorities spent £347m in 2011-12 on providing free personal and nursing care to older people in their own homes—2.5 times the £133m spent in 2003-04. Meanwhile, local authority spending on free personal and nursing care for self …
The Incidence, Pattern, and Prognostic Value of Left Ventricular Myocardial Scar by Late Gadolinium Enhancement in Patients With Atrial Fibrillation
Authors: Tomas G. Neilan, Ravi V. Shah, Siddique A. Abbasi, Hoshang Farhad, John D. Groarke, John A. Dodson, Otavio Coelho-Filho, Ciaran J. McMullan, Bobak Heydari, Gregory F. Michaud, Roy M. John, Rob van der Geest, Michael L. Steigner, Ron Blankstein, Michael Jerosch-Herold, Raymond Y. Kwong
Journal: Journal of the American College of Cardiology (2013)
Omega Yes, Alpha No
Authors: Franz von Lichtenberg
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Dundee coronary risk-disk for management of change in risk factors.
Authors: H Tunstall-Pedoe
Journal: BMJ (1991)

OBJECTIVE--To devise a simplified system for grading and monitoring modifiable coronary risk in primary care, to be used with an action plan. METHODS--The risk equation came from 5203 men aged 40-59 in the United Kingdom heart disease prevention project, who had 331 coronary events over five years; the population rank (reading 1-100) was obtained by scoring 10,359 participants in the Scottish heart health study. Calculation of rank was embodied in the Dundee coronary risk-disk; the formula was tested against the Whitehall study; disk and action plan were evaluated in primary care. RESULTS--The system measures modifiable coronary risk from smoking, blood pressure, and blood cholesterol concentration by a sex and age related rank running from 1 (high risk, priority action) to 100 (low risk, general advice). The formula predicted outcome acceptably in the Whitehall study and is built into a circular slide rule. Only eight (11%) of 76 general practitioners and practice nurses surveyed already used risk factor scores. After evaluation most thought they should use one and proposed to incorporate the Dundee coronary risk-disk and the associated action plan into their routines. CONCLUSION--The Dundee coronary risk-disk readout of Dundee rank, standardised on a scale of 1 to 100 by age and sex, is a simple, valid means of assessing and monitoring modifiable coronary risk. It puts single risk factors (such as cholesterol concentration) in perspective and can aid selective testing. Understood by medical staff and patients, it should improve the efficiency and effectiveness of the high risk approach to coronary prevention.
Effect of Volume Expansion on Hemodynamics, Capillary Permeability and Renal Function in Conscious, Cirrhotic Rats
Authors: Carlos Caramelo, Dolores Fernandez-Muñoz, Juan C. Santos, Alicia Blanchart, Diego Rodriguez-Puyol, José M. López-Novoa, Luis Hernando
Journal: Hepatology (1986)

General and splanchnic hemodynamics (radioactive microspheres), renal function, spontaneous and histamine-mediated vasopermeability and albumin distribution space were studied in conscious control and nonascitic cirrhotic rats, before and after a moderate and sustained saline infusion (3% of body weight per 30 min + repletion of urinary losses). In basal conditions, cirrhotic rats showed lower fractional sodium excretion than did control rats (0.09 +/- 0.01 vs. 0.15 +/- 0.01%, p less than 0.005). In addition, cirrhotic animals showed higher cardiac output (161.4 +/- 12.8 ml per min) and lower total peripheral resistance (0.63 +/- 0.05 mm Hg . min per ml) and mean arterial pressure (102.9 +/- 3.9 mm Hg) than did control rats (cardiac output: 89.0 +/- 7.6; total peripheral resistance: 1.31 +/- 0.11; mean arterial pressure: 117.5 +/- 5.11; p less than 0.005). No differences in portal-systemic shunt rate or vasopermeability between both groups were observed. After saline infusion, fractional sodium excretion increased to 4.31 +/- 0.16% in controls but only 2.11 +/- 0.02% in cirrhotic animals. In this group, cardiac output decreased by 49.6 +/- 5.1% whereas mean arterial pressure and total peripheral resistance increased by 7.1 +/- 0.6 and 112 +/- 10%, respectively. In control rats, no significant hemodynamic changes were observed. Blood gases did not change after expansion in any group. Saline infusion induced an increase in histamine-mediated vasopermeability in cirrhotic rats but not in control rats. Also albumin distribution space increased more in cirrhotic than in control animals. Heart weight was higher in cirrhotic rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Synergistic Effects of Gemcitabine and Gefitinib in the Treatment of Head and Neck Carcinoma
Authors: Patrick Y. Chun, Felix Y. Feng, Ashley M. Scheurer, Mary A. Davis, Theodore S. Lawrence, Mukesh K. Nyati
Journal: Cancer Research (2006)

Although the combination of gemcitabine and radiation produces a high frequency of complete responses in the treatment of locally advanced head and neck cancer, substantial toxicity suggests that an improvement in the therapeutic index is required. The purpose of this study was to determine if gefitinib could improve the efficacy of gemcitabine and if drug schedule is important. We hypothesized that gemcitabine followed by gefitinib would be superior to the opposite order because of both cell cycle and growth factor signaling interactions. Using UMSCC-1 cells in vitro, we confirmed that gefitinib arrested cells in G(1) and suppressed phospho-epidermal growth factor receptor (p(Y845)EGFR) and that gemcitabine arrested cells in S phase and stimulated p(Y845)EGFR. The schedule of gemcitabine followed by gefitinib caused arrest of cells in S phase. Gefitinib suppressed gemcitabine-mediated p(Y845)EGFR stimulation. This schedule caused decreased p(S473)AKT, increased poly(ADP-ribose) polymerase cleavage, and increased apoptosis compared with gemcitabine alone. The schedule of gefitinib followed by gemcitabine also caused suppression of p(Y845)EGFR but arrested cells in G(1). This schedule in which gefitinib was used first was associated with stable levels of p(S473)AKT and minimal poly(ADP-ribose) polymerase cleavage and apoptosis. These results were reflected in experiments in nude mice bearing UMSCC-1 xenografts, in which there was greater tumor regression and apoptosis when animals received gemcitabine followed by gefitinib during the first week of therapy. These findings suggest that the schedule of gemcitabine followed by gefitinib may increase the therapeutic index over gemcitabine alone and, combined with clinical data, encourage exploration of combination of gemcitabine, EGFR inhibitors, and radiation.
Frail Older Adults and Palliative Care
Authors: Daniel Cormican, Peggy A. Seidman
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeted Disruption of the 3p12 Gene, <b> <i>Dutt1/Robo1</i> </b>, Predisposes Mice to Lung Adenocarcinomas and Lymphomas with Methylation of the Gene Promoter
Authors: Jian Xian, Alan Aitchison, Linda Bobrow, Gerard Corbett, Richard Pannell, Terence Rabbitts, Pamela Rabbitts
Journal: Cancer Research (2004)

The DUTT1 gene is located on human chromosome 3, band p12, within a region of nested homozygous deletions in breast and lung tumors. It is therefore a candidate tumor suppressor gene in humans and is the homologue (ROBO1) of the Drosophila axonal guidance receptor gene, Roundabout. We have shown previously that mice with a targeted homozygous deletion within the Dutt1/Robo1 gene generally die at birth due to incomplete lung development: survivors die within the first year of life with epithelial bronchial hyperplasia as a common feature. Because Dutt1/Robo1 heterozygous mice develop normally, we have determined their tumor susceptibility. Mice with a targeted deletion within one Dutt1/Robo1 allele spontaneously develop lymphomas and carcinomas in their second year of life with a 3-fold increase in incidence compared with controls: invasive lung adenocarcinomas are by far the predominant carcinoma. In addition to the mutant allele, loss of heterozygosity analysis indicates that these tumors retain the structurally normal allele but with substantial methylation of the gene's promoter. Substantial reduction of Dutt1/Robo1 protein expression in tumors is observed by Western blotting and immunohistochemistry. This suggests that Dutt1/Robo1 is a classic tumor suppressor gene requiring inactivation of both alleles to elicit tumorigenesis in these mice.
Monoclonal Antibody-Based Therapies: A New Dawn in the Treatment of Acute Lymphoblastic Leukemia
Authors: Hagop Kantarjian, Deborah Thomas, Alan S. Wayne, Susan O'Brien
Journal: Journal of Clinical Oncology (2012)

Article Tools Review Articles Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2012.41.6768 Journal of Clinical Oncology - published online before print August 13, 2012 PMID: 22891271 Monoclonal Antibody-Based Therapies: A New Dawn in the Treatment of Acute Lymphoblastic Leukemia Hagop KantarjianxHagop KantarjianSearch for articles by this author , Deborah ThomasxDeborah ThomasSearch for articles by this author , Alan S. WaynexAlan S. WayneSearch for articles by this author , Susan O'BrienxSusan O'BrienSearch for articles by this author Show More Hagop Kantarjian, Deborah Thomas, and Susan O'Brien, MD Anderson Cancer Center, Houston, TX; and Alan S. Wayne, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. https://doi.org/10.1200/JCO.2012.41.6768 First Page Full Text PDF Figures and Tables © 2012 by American Society of Clinical Oncology
445 rs4374383 SINGLE NUCLEOTIDE POLYMORPHISM OF MERTK GENE INFLUENCES THE PROGRESSION OF LIVER FIBROSIS IN THALASSEMIA MAJOR PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION
Authors: V. Calvaruso, F. Bronte, S. Grimaudo, A. Di Cristina, V. Di Marco
Journal: Journal of Hepatology (2013)
Triple Starr Valve Replacement
Authors: M. V. Braimbridge, A. J. Clement, A. H. Brown, E. Sabar, D. Mendel
Journal: BMJ (1969)

Of nine patients who have had triple valve replacements for organic rheumatic triple valve disease two died in the postoperative period from inadequate myocardial reserve, and a third died four months later from cerebral embolism originating from clot on the left atrial wall. The remainder are well and, except for one, leading normal lives. Though cardiac transplantation has been recommended and used successfully for triple valve disease by Cooley, it is suggested that the long-term outlook today of triple valve replacement is likely to be better than that of transplantation.
Quebec increases funding to fight infections in hospitals
Authors: David Spurgeon
Journal: BMJ (2005)

The Quebec government has announced that it will increase funding for hospitals' infection control programmes by $C20m (£8.6m; $16.1m; €12.4m). Meanwhile preliminary findings have indicated that Clostridium difficile infections in the province's hospitals have dropped substantially from levels in last year's outbreak.

The infection was said last June to have killed more Canadians than were killed by the 2003 outbreak of severe acute respiratory syndrome (SARS) ( BMJ 2004;328:1457).

Among 88 hospitals in the province, the median infection rate was 11.7 people per 10 000 hospital days from the end of …