Adverse Hemodynamic Effects of Phentolamine in Primary Pulmonary Hypertension
Authors: MURRAY L. COHEN
Journal: Annals of Internal Medicine (1981)

Brief Reports1 November 1981Adverse Hemodynamic Effects of Phentolamine in Primary Pulmonary HypertensionMURRAY L. COHEN, M.D., ITZHAK KRONZON, M.D.MURRAY L. COHEN, M.D., ITZHAK KRONZON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-5-591 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrimary pulmonary hypertension is a disease of unknown cause that presents with a progressive rise in pulmonary artery pressure leading almost inevitably to the development of right-sided heart failure and death. This disorder occurs most frequently in women during the second and third decade of life (1, 2).Increased pulmonary vascular resistance associated with an increased pulmonary artery pressure and normal left-sided pressure form the physiologic basis of the diagnosis (2). The decrease in pulmonary vascular resistance in response to vasodilators seen early in the course of the disease is lost as the disease progresses (3). Wagenvoort and Wagenvoort (1)...References1. WAGENVOORTWAGENVOORT CN. Primary pulmonary hypertension—a pathological study of the lung vessels in 156 clinically diagnosed cases. Circulation. 1970;42:1163-84. CrossrefGoogle Scholar2. FISHMANPIETRA AG. Primary pulmonary hypertension. Annu Rev Med. 1980;3:421-31. CrossrefGoogle Scholar3. KANEMOTOSASAMOTO NH. Pulmonary hemodynamics in primary pulmonary hypertension. Jap Heart J. 1979;20:395-405. CrossrefMedlineGoogle Scholar4. RUSKINHUTTER JA. Primary pulmonary hypertension treated with oral phentolamine. Ann Intern Med. 1979;90:772-4. LinkGoogle Scholar5. GOODMANGILMAN LA. The Pharmacological Basis of Therapeutics. New York: The MacMillan Company; 1966:556-8. Google Scholar6. TAYLORSUTHERLANDMACKENZIESTAUNTONDONALD SGGHK. The circulatory effect of intravenous phentolamine in man. Circulation. 1965;31:741-54. CrossrefMedlineGoogle Scholar7. TAYLORMACKENZIEGEORGEMCDONALD SGMA. Effects of adrenergic blockade on the pulmonary circulation in man. Br Heart J. 1965;27:627-39. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York University Medical Center New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTransection of the cervical sympathetic trunk inhibits the progression of pulmonary arterial hypertension via ERK-1/2 SignallingVasodilator responsiveness in idiopathic pulmonary arterial hypertension: identifying a distinct phenotype with distinct physiology and distinct prognosisPharmacotherapy for Idiopathic Pulmonary Arterial Hypertension During the Past 25 YearsAlpha-Adrenergic Blocking Drugs in Clinical MedicinePulmonary Hypertension and Selective Pulmonary Vasodilators in Acute Lung InjuryMedical treatment of primary pulmonary hypertension: A bridge to transplantation?Pharmacotherapy of Chronic Pulmonary Arterial Hypertension: Value and LimitationsSouthwestern Internal Medicine Conference: Primary Pulmonary HypertensionCardiovascular-Pulmonary Interaction in Chronic Obstructive Pulmonary Disease with Special Reference to the Pathogenesis and Management of Cor PulmonalePrimary pulmonary hypertension. Vascular structure, morphometry, and responsiveness to vasodilator agents.Long-term clinical results after vasodilator evaluation in patients with primary (unexplained) and secondary precapillary pulmonary hypertension: acute hemodynamic comparisons and long-term survivalPrimary pulmonary hypertensionα-Adrenergic BlockersManagement of Primary Pulmonary HypertensionThe effects of long term methyldopa in patients with hypoxic cor pulmonaleNatural history of pulmonary hemodynamics in primary pulmonary hypertensionA comparison of the acute hemodynamic effects of prostacyclin and hydralazine in primary pulmonary hypertensionCalcium Channel Blockers in Primary Pulmonary HypertensionVasodilator Therapy for Primary Pulmonary Hypertension Limitations and HazardsMILTON PACKER, M. D.Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertensionCalcium channel blockers in hypoxic pulmonary hypertensionTherapeutic application of calcium-channel antagonists for pulmonary hypertensionManagement of primary pulmonary hypertension.Adverse hemodynamic and clinical effects of calcium channel blockade in pulmonary hypertension secondary to obliterative pulmonary vascular diseaseVasodilator Therapy for Primary Pulmonary HypertensionHemodynamic effects of nifedipine versus hydralazine in primary pulmonary hypertensionTherapy of Pulmonary Heart DiseaseDrugs in the Treatment of Primary Pulmonary Arterial HypertensionOral Nifedipine in Chronic Cor Pulmonale Secondary to Severe Chronic Obstructive Pulmonary Disease (COPD)Acute Hemodynamic Effects of Nitroglycerin in Pulmonary HypertensionRONALD G. PEARL, M.D., MYER H. ROSENTHAL, M.D., JOHN S. SCHROEDER, M.D., J. P. A. ASHTON, C.P.T.Contrasting acute effects of vasodilators (nitroglycerin, nitroprusside, and hydralazine) on right ventricular performance in patients with chronic obstructive pulmonary disease and pulmonary hypertension: A combined radionuclide-hemodynamic studyCardiovascular Effects of Vasodilator Therapy for Pulmonary Arterial HypertensionEffects of Nifedipine on Ventilation/Perfusion Matching in Primary Pulmonary HypertensionDeleterious Effects of Hydralazine in Patients with Pulmonary HypertensionCorrection: Paper on Primary Pulmonary HypertensionRight Ventricular Unloading: Lessons from the LeftJOSEPH A. FRANCIOSA, M.D., HERBERT A. FISCHER, M.D. 1 November 1981Volume 95, Issue 5Page: 591-592KeywordsHeart diseasesHeart failureHemodynamicsPulmonary arteriesPulmonary diseasesPulmonary hypertensionPulmonary vascular diseasesPulmonary vascular resistanceVascular diseasesVasodilators Issue Published: 1 November 1981 PDF DownloadLoading ...