tbuckley/cabot-search huggingface dataset:
Vancomycin-Resistant Staphylococcus aureus
Authors: C.M.J.E. Vandenbroucke-Grauls
Journal: Annals of Internal Medicine (1996)

Letters15 November 1996Vancomycin-Resistant Staphylococcus aureusC.M.J.E. Vandenbroucke-Grauls, MD, PhDC.M.J.E. Vandenbroucke-Grauls, MD, PhDUniversity Hospital Vrije Universiteit, Amsterdam, the Netherlands.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-10-199611150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their paper on measures for control of vancomycin-resistant S. aureus, Edmond and colleagues [1] thoroughly review the measures that should be followed to prevent nosocomial transmission of these strains. However, they state that their proposals are based on the limited data available on the control and transmission of S. aureus. In the Netherlands, we have experience with control of methicillin-resistant S. aureus. Since 1988, ongoing surveillance by the National Institute of Public Health and Environmental Protection shows that in the Netherlands (a country that has 15 million inhabitants and about 150 hospitals), the number of cases ...References1. Edmond MB, Wenzel RP, Pasculle AW. Vancomycin-resistant Staphylococcus aureus: perspectives on measures needed for control. Ann Intern Med. 1996; 124:329-34. Google Scholar2. van Leeuwen WJ, Schot CS, Rost JA, Neeling AJ, van Klingeren B. Surveillance of Methicillin-Resistant Staphylococcus aureus in the Netherlands from 1992 to 1994. National Institute of Public Health and Environmental Protection Report no. 359002004; 1995. Google Scholar3. Vandenbroucke-Grauls CM. Epidemiology of staphylococcal infections: a European perspective. J Chemother. 1994; 6(Suppl 2):35-9. Google Scholar4. Management Policy for Methicillin-Resistant Staphylococcus aureus. Guideline of the Working Party Infection Prevention. No. 35a; 1995. Google Scholar Author, Article, and Disclosure InformationAffiliations: University Hospital Vrije Universiteit, Amsterdam, the Netherlands. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1996Volume 125, Issue 10Page: 859KeywordsEnvironmental healthEpidemiologyMicrobiologyPatient advocacyPrevention, policy, and public healthResearch laboratoriesStaphylococcus aureus Issue Published: 15 November 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Health Care Injustice Fuels Rage, Riots
Authors: Paul Cotton
Journal: JAMA (1992)

JUST HOURS before the now world-famous Rodney King verdict ignited this country's worst riots of this century, a meeting was held in Los Angeles, Calif, to address another perceived injustice.   days of violence that followed are reflecting a harsh light on what otherwise would have been obscure beginnings for the Los Angeles County Board of Supervisors' Task Force on Health Care Access, an earnest group with representation from virtually every pertinent interest group except underserved people and the minority physicians most likely to care for them.  Access to health care, which is abysmal nationwide, is perhaps poorest in Los Angeles County. Fully 27% of the population is completely uninsured, and fewer and fewer physicians are taking patients covered by Medical, the state's program for the poor, because they say its meager payments do not meet even their overhead costs.  The safety net is torn to pieces. There is widespread
Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD): The TRIPOD Statement
Authors: Gary S. Collins, Johannes B. Reitsma, Douglas G. Altman, Karel G.M. Moons
Journal: European Urology (2015)

Prediction models are developed to aid health care providers in estimating the probability or risk that a specific disease or condition is present (diagnostic models) or that a specific event will occur in the future (prognostic models), to inform their decision making. However, the overwhelming evidence shows that the quality of reporting of prediction model studies is poor. Only with full and clear reporting of information on all aspects of a prediction model can risk of bias and potential usefulness of prediction models be adequately assessed.
Reply to “On the cloning of animals from terminally differentiated cells”
Authors: Xiangzhong Yang, Tao Cheng, Li-Ying Sung, Shaorong Gao, Hongmei Shen, Hui Yu, Yifang Song, Sadie L Smith, David P Tuck, Kimiko Inoue, Sherman M Weissman
Journal: Nature Genetics (2007)
Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4
Authors: Pilar Ramos, Anthony N Karnezis, David W Craig, Aleksandar Sekulic, Megan L Russell, William P D Hendricks, Jason J Corneveaux, Michael T Barrett, Karey Shumansky, Yidong Yang, Sohrab P Shah, Leah M Prentice, Marco A Marra, Jeffrey Kiefer, Victoria L Zismann, Troy A McEachron, Bodour Salhia, Jaime Prat, Emanuela D'Angelo, Blaise A Clarke, Joseph G Pressey, John H Farley, Stephen P Anthony, Richard B S Roden, Heather E Cunliffe, David G Huntsman, Jeffrey M Trent
Journal: Nature Genetics (2014)
Angiotensinogen gene associated polymorphisms and risk of stroke in sickle cell anemia: Additional data supporting an association
Authors: Marc Romana, Jean‐Pierre Diara, Lydia Doumbo, Shanmugakonar Muralitharan, Rajendranath Ramasawmy, Lysiane Keclard, Vanessa Tarer, Vicky Chaar, Jacques Elion, Rajagopal Krishnamoorthy, John Clayton
Journal: American Journal of Hematology (2004)
Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.
Authors: P Billings, S J Burakoff, M E Dorf, B Benacerraf
Journal: The Journal of Experimental Medicine (1978)

The ability of cytotoxic T lymphocytes (CTL) induced in vitro to trinitrophenyl (TNP)-modified syngeneic cells to cross-reactively lyse a TNP allogeneic spleen target varies among inbred mouse strains. The cross-reactive CTL phenotype was found to be histocompatibility 2 (H-2) linked and to be dominant in F1 hybrid mice. All strains investigated demonstrated cross-reactivity except for some strains bearing portions of the H-2k haplotype. The gene(s) controlling this response maps to the K and/or I-A region of the H-2 complex. We have termed the immune response (Ir) gene responsible for controlling the specificity of CTL induced to TNP-modified syngeneic cells Ir-X-TNP.
Premature Mitral Valve Closure
Authors: W. R. MEADOWS, STELLA VAN PRAAGH, MEILUTE INDREIKA, J. T. SHARP
Journal: Circulation (1963)

The phenomenon of premature mitral valve closure is described in three patients with severe aortic insufficiency and related to absence of the first heart sound. The occurrence of premature mitral closure is favored by severe aortic regurgitation probably with increased impedance to left ventricular filling. Available evidence suggests that this phenomenon usually occurs in the more rapidly developing forms of aortic incompetence (bacterial endocarditis, post surgical, and traumatic rupture of the valve), that it is uncommon, and that it often implies a grave prognosis. It should be suspected when the apical first heart sound is absent in aortic incompetence.
417 VIRTUAL TOUCH ASSESSMENT OF LIVER STIFFNESS IN CHRONIC LIVER DISEASE: COMPARISON WITH TRANSIENT ELASTOGRAPHY
Authors: F. Piscaglia, V. Salvatore, R. Di Donato, A. Borghi, S. Gualandi, E. Peri, F. Conti, A. Cucchetti, P. Andreone, L. Bolondi
Journal: Journal of Hepatology (2010)
A simple grading system to guide the prognosis after hip fracture in the elderly.
Authors: R G Wallace, J H Lowry, N W McLeod, R A Mollan
Journal: BMJ (1986)

treatment, and 88 mm Hg after six months' treatment (p>05, paired l test; 95% confidence interval for the difference between means -3 to + 4 mm Hg).Similar stability was seen in the placebo group, in whom the corresponding diastolic pressures were 93, 92, and 92 mm Hg (p>030, paired t test; 95% confidence interval -5 to + 2 mm Hg).After six months' treatment the change in blood pressure from the pretreatment value was not significandy different between the two groups (diastolic: p=0A4 (unpaired t test), 95% confidence interval for the difference between means -3 to + 7 mm Hg; systolic: p=0-9 (unpaired t test), 95% confidence interval -9 to + 8 mm Hg).There was no significant difference in serum magnesium, potassium, sodium or creatinine concentrations between the two groups after six months' treatment (p>0 05, unpaired t test).
Lack of Estrogen Receptor-α Is Associated with Epithelial–Mesenchymal Transition and PI3K Alterations in Endometrial Carcinoma
Authors: Elisabeth Wik, Maria B. Ræder, Camilla Krakstad, Jone Trovik, Even Birkeland, Erling A. Hoivik, Siv Mjos, Henrica M.J. Werner, Monica Mannelqvist, Ingunn M. Stefansson, Anne M. Oyan, Karl H. Kalland, Lars A. Akslen, Helga B. Salvesen
Journal: Clinical Cancer Research (2013)

We hypothesized that estrogen receptor-α (ER-α) status in endometrial carcinomas, associated with poor prognosis, is reflected in transcriptional signatures suggesting targets for new therapy.Endometrial carcinoma samples in a primary investigation cohort (n = 76) and three independent validation cohorts (n = 155/286/111) were analyzed through integrated molecular profiling. Biomarkers were assessed by immunohistochemistry (IHC), DNA oligonucleotide microarray, quantitative PCR (qPCR), single-nucleotide polymorphism (SNP) array, and Sanger sequencing in the cohorts, annotated for comprehensive histopathologic and clinical data, including follow-up.ER-α immunohistochemical staining was strongly associated with mRNA expression of the receptor gene (ESR1) and patient survival (both P < 0.001). ER-α negativity associated with activation of genes involved in Wnt-, Sonic Hedgehog-, and TGF-β signaling in the investigation cohort, indicating epithelial-mesenchymal transition (EMT). The association between low ER-α and EMT was validated in three independent datasets. Furthermore, phosphoinositide 3-kinase (PI3K) and mTOR inhibitors were among the top-ranked drug signatures negatively correlated with the ER-α-negative tumors. Low ER-α was significantly associated with PIK3CA amplifications but not mutations. Also, low ER-α was correlated to high expression of Stathmin, a marker associated with PTEN loss, and a high PI3K activation signature.Lack of ER-α in endometrial cancer is associated with EMT and reduced survival. We present a rationale for investigating ER-α's potential to predict response to PI3K/mTOR inhibitors in clinical trials and also suggest EMT inhibitors to ER-α-negative endometrial carcinomas.
A Visit to the Doctor
Authors: Deborah Young Bradshaw
Journal: Annals of Internal Medicine (1999)

On Being a Patient19 October 1999A Visit to the DoctorDeborah Young Bradshaw, MDDeborah Young Bradshaw, MDSUNY Health Science Center at Syracuse; Syracuse, NY 13210 (Bradshaw)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-8-199910190-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The door opened without resistance, and I entered. The doctor's waiting room was decorated with the popular industrial plums, blues, and grays, but there was enough mahogany to impart a sense of reverence. The room was tasteful yet warm, and it reassured me. I was surprised to be greeted there by a patient of my own, a doctor himself. It was like looking into a mirror, with doctor doctoring doctor, doctoring doctor, receding into infinity. My patient was an elderly man, a retired army physician, refined and gentle, with a keen if fading intellect. I sat one chair away from ... Author, Article, and Disclosure InformationAffiliations: SUNY Health Science Center at Syracuse; Syracuse, NY 13210 (Bradshaw)Corresponding Author: Deborah Young Bradshaw, MD, 750 East Adams Street, Syracuse, NY 13210; e-mail, [email protected]hscsyr.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLife on the Receiving End: A Qualitative Analysis of Health Providers??? Illness Narratives 19 October 1999Volume 131, Issue 8Page: 627-628KeywordsChildrenGratitudeHead liceHearingHeartNursesRiversSyncopeSystematic reviewsTouch Issue Published: 19 October 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Campaign for real healthcare for real people
Authors: T. Delamothe
Journal: BMJ (2013)

Providing parity of care for hospital patients across the whole week is a goal that’s hard to oppose, and the Academy of Medical Royal Colleges has been working out the implications (doi:10.1136/bmj.f6716). Its survey suggests that most medical specialties would need to provide about six hours of consultant input per day to review 30 inpatients at the weekend.

But wait a minute, cries Anthony Cohn. Patients aren’t receiving anything like that on weekday ward rounds (doi:10.1136/bmj.f6451). “Experience and anecdote indicate that it is typical that 20 or more patients need to be seen in two hours—five minutes per patient on average, assuming all notes, radiographs, and results are immediately to hand. This compares poorly …
Human infection with avian influenza A(H7N9) virus re-emerges in China in winter 2013
Authors: E Chen, Y Chen, L Fu, Z Chen, Z Gong, H Mao, D Wang, M Y Ni, P Wu, Z Yu, T He, Z Li, J Gao, S Liu, Y Shu, B J Cowling, S Xia, H Yu
Journal: Eurosurveillance (2013)

Through a national surveillance system for unexplained pneumonia, a severe case of influenza A(H7N9) in a man in his mid-30s was identified in Zhejiang Province, China on 14 October 2013. Epidemiological and clinical findings were consistent with the patterns reported during the outbreak in spring 2013, and laboratory findings showed that the virus had 99.6% identity with earlier H7N9 viruses identified in humans in the spring except for five mutations in the NA gene.
MEDICAL ASSOCIATION OF THE STATE OF ALABAMA
Authors: Harry T. Inge
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reduction of ventricular arrhythmias by early intravenous atenolol in suspected acute myocardial infarction.
Authors: P R Rossi, S Yusuf, D Ramsdale, L Furze, P Sleight
Journal: BMJ (1983)

The effect of intravenous atenolol on ventricular arrhythmias in acute myocardial infarction was assessed in 182 patients admitted within 12 hours of the onset of chest pain. Ninety-five patients were randomised to receive 5 mg intravenous atenolol followed immediately by 50 mg by mouth and 50 mg 12 hours later, then 100 mg daily for 10 days; 87 patients served as controls. The treated patients had significantly fewer ventricular extrasystoles; 58 control patients (67%) had R-on-T extrasystoles compared with only 25 treated patients (26%) (2p less than 0.0001); repetitive ventricular arrhythmias were detected in 64 control patients (74%) and 55 treated patients (58%) (2p less than 0.05). Heart rate was significantly reduced from 77 +/- 1 beats/min at entry to 65 +/- 1 beats/min (2p less than 0.001) in the first hour after intravenous atenolol, and in addition the rate was significantly different from that in the control group. There was no difference in the incidence of heart failure, but fewer patients in the treated group received other antiarrhythmic agents or digoxin. These results show that early intravenous atenolol prevents ventricular arrhythmias in suspected acute myocardial infarction.
Discussion on banning advertising of cosmetic surgery needs to consider medical tourists
Authors: J. Hanefeld, N. Lunt, D. Horsfall, R. Smith
Journal: BMJ (2012)

The discussion on banning advertising of cosmetic surgery neglects an important aspect of safeguarding UK consumers from direct marketing by cosmetic surgery providers to the public1: an increasing number of UK patients travel abroad for cosmetic surgery.

In 2010, 63 000 UK residents travelled to access treatment abroad.2 Our research indicates that around 30% …
The Fifth Branch: Science Advisors as Policymakers
Authors: Ronald Andersen
Journal: JAMA (1991)

We learned in our civics classes that the federal government has three branches: executive, legislative, and judicial. In practice, observers of the governmental process have long recognized the importance of a fourth branch—the regulatory agencies such as the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA), which have much to do with interpreting laws, writing regulations, and enforcing them. The proliferation of science and technology and the resulting products and services have led these agencies to seek expert, scientific advice concerning health, safety, and environmental policy. Sheila Jasanoff views the scientific advisory process as so pervasive and influential that she has labeled it "the fifth branch." These scientific advisers play central roles in determining whether we should "eat supermarket apples, use hair spray, drive cars in inner cities, incinerate our wastes, generate nuclear energy, [or] release genetically engineered organisms into the environment" (p v). Despite this influence,
The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology
Authors: Aisling O’Hara Hall, Daniel P. Beiting, Cristina Tato, Beena John, Guillaume Oldenhove, Claudia Gonzalez Lombana, Gretchen Harms Pritchard, Jonathan S. Silver, Nicolas Bouladoux, Jason S. Stumhofer, Tajie H. Harris, John Grainger, Elia D. Tait Wojno, Sagie Wagage, David S. Roos, Philip Scott, Laurence A. Turka, Sara Cherry, Steven L. Reiner, Daniel Cua, Yasmine Belkaid, M. Merle Elloso, Christopher A. Hunter
Journal: Immunity (2012)
External Ureteral Compression to Identify the Origin of Hematuria
Authors: WILLIAM M. HAMBY
Journal: Annals of Internal Medicine (1964)

Article1 December 1964External Ureteral Compression to Identify the Origin of HematuriaWILLIAM M. HAMBY, M.D., LIONEL M. BERNSTEIN, M.D., PH.D.WILLIAM M. HAMBY, M.D.Search for more papers by this author, LIONEL M. BERNSTEIN, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-6-1104 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne difficulty in patients with hematuria has been localization of the bleeding site. The preparation and specialized skills required for cystoscopy prevent prompt performance of this procedure. Frequently it is not performed until after bleeding has stopped. Not knowing the origin of bleeding hinders further evaluation.A simple, safe, clinically practical technique whereby either or both ureters can be occluded for short periods of time by abdominal compression has been described (1). The purpose of this paper is to present data which show that the origin of genitourinary bleeding can be localized by unilateral urine sampling using external ureteral compression....Reference1. BERNSTEINHAMBY LMWM: Unilateral urine sampling utilizing external ureteral compression. New Eng. J. Med. 268: 1093, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM M. HAMBY, M.D.; LIONEL M. BERNSTEIN, M.D., PH.D.Affiliations: Chicago, IllinoisFrom the Renal Research Laboratory and the Medical Service, Veterans Administration West Side Hospital and the Department of Medicine, University of Illinois College of Medicine, Chicago, Ill.Requests for reprints should be addressed to William M. Hamby, M.D., Staff Physician, Medical Service, Veterans Administration West Side Hospital, 820 South Damen Ave., Chicago, Ill. 60612. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1964Volume 61, Issue 6Page: 1104-1108KeywordsCystoscopyHemorrhageHospital medicineMedical servicesResearch laboratoriesUreterUrine ePublished: 1 December 2008 Issue Published: 1 December 1964 PDF downloadLoading ...
Pulmonary Involvement in Rheumatoid Arthritis
Authors: Porfirio Cervantes-Perez
Journal: JAMA (1980)

Diffuse pulmonary affection in rheumatoid arthritis remains a controversial subject that requires further and more accurate investigation. All patients with rheumatoid arthritis attending a general hospital during a six-year period underwent clinical, radiological, and functional pulmonary evaluation and serological investigation. Twenty-five had an open lung biopsy for microscopic examination and immunofluorescence. The histopathological findings in this group were correlated with the clinical, radiological, functional, and serological altercations and with the clinical course of the rheumatoid process as well. Pulmonary affection in this series was a common finding, showing definite histopathological patterns and particular clinical features.
UK health secretary accuses BMA of distorting government proposals for polyclinics
Authors: Deborah Cohen
Journal: BMJ (2008)

Alan Johnson this week attacked the BMA for its “ludicrous misrepresentation” of UK government proposals for polyclinics, in a speech at the launch of a government report about health inequalities.

At the event, organised by the Institute for Public Policy Research, he described the opposition by the BMA and the Conservative party to the government plans as “a faint echo of their infamous double act 60 years ago, when they opposed the creation of the NHS itself.”

The speech followed a week of growing tension between the Department of Health and the BMA about polyclinics, including an article in the Observer newspaper by Alan Johnson accusing the …
Fighting Infection: Conquests of the 20th Century
Authors: Lester S. King
Journal: JAMA (1977)

In medicine, unfortunately, there is an all-too-prevalent attitude that anything more than 20 years old is of antiquarian interest only. However, if we can avoid this parochial viewpoint and learn to appreciate history, we can gain an insight that comes only from understanding the background, the problems, and the special difficulties. Dr Dowling's latest book provides just such an insight in regard to infectious diseases. He has personally played an important part in the development of antibioties, and his own experience provides a quality to the exposition that no mere study of sources could possibly generate. Furthermore, he brings a sound historical knowledge of medicine of the past century and a minute acquaintance with the literature relevant to his own research. This background, combined with an engaging literary style, results in a book both enjoyable and rewarding. Dowling does not try to cover all infectious diseases but wisely limits himself