tbuckley/cabot-search huggingface dataset:
Offending in psychiatric patients after discharge from medium secure units: Author's reply
Authors: A Maden
Journal: BMJ (2004)

EDITOR—Back seat drivers are the worst critics. Yes, we could have used additional measures of violent offending. The Macarthur study (cited in the paper) did that but cost $8m (£4.4m; €6.5m) for a similar sample size and 50% less follow up. I have offered to do the same thing over here for half the price but have had no takers …
Does Genetic Testing Really Improve the Prediction of Future Type 2 Diabetes?
Authors: A. Cecile J. W Janssens, Marta Gwinn, Subramony Subramonia-Iyer, Muin J Khoury
Journal: PLoS Medicine (2006)

I would like to thank PLoS Medicine for publishing Lacasse and Leo's important and methodical Essay that debunks the "chemical imbalance" advertisements for psychiatric drugs [1].Why would the United States Food and Drug Administration (FDA) approve such ads?Our human rights group, MindFreedom International, has been asking that question for a long time.On behalf of MindFreedom, US Senator Ron Wyden contacted the FDA for an explanation about why they approve such advertising.In their responsewhich took over one year to receive-the FDA could cite no scientifi c literature or studies.It turns out there's a good reason that the FDA can't fi nd any scientifi c evidence for the claims of a "chemical imbalance" in these ads: the scientifi c evidence in support of the serotonin hypothesis is very weak.Readers who would like more information about the psychiatric industry's advertising suggesting a "chemical imbalance" in depression may be interested in the following:(1) MindFreedom's debate with Pfi zer, manufacturer of Zoloft, available at http:⁄⁄www.mindfreedom.org/mindfreedom/pfi zerlies.shtml,and (2) a historic debate with the American Psychiatric Association resulting from MindFreedom's 2003 hunger strike, available at http:⁄⁄www.mindfreedom.org/mindfreedom/hungerstrike.shtml
Lymphocyte and complement abnormalities in splenectomized patients with hematologic disorders
Authors: Winfred C. Wang, Henry G. Herrod, William R. Valenski, Robert J. Watt
Journal: American Journal of Hematology (1988)

Abstract Twenty‐two patients, splenectomized 1 to 26 years earlier for hematologic disorders, were studied to determine possible defects in immunologic function or complement levels. Quantitation of B cells and T‐cell subsets revealed slight decreases in the proportions of CD3 and CD4 cells but normal or increased absolute numbers of all cell populations. IgM synthesis in vitro by peripheral blood mononuclear cells was markedly diminished, but IgG synthesis was normal. Fractionation studies, in which various B‐cell‐ and T‐cell‐enriched populations from controls and patients were combined, demonstrated diminished B‐cell function in the patients. Sickle cell patients, who were functionally asplenic, showed similar deficits. Complement levels in splenectomized and sickle cell patients in both the classical and alternative pathways were generally normal. A modest decrease in component H in the alternative pathway in splenectomized and sickle cell patients probably was not clinically significant. In summary, splenectomized patients have a diminished capacity for IgM synthesis that can be attributed primarily to defective B‐cell function. This may be partially responsible for their increased susceptibility to infection by encapsulated organisms.
Genital Human Papillomavirus Infection in Female University Students as Determined by a PCR-Based Method
Authors: Heidi M. Bauer
Journal: JAMA (1991)

The presence of genital human papillomavirus (HPV) was determined at cervical and vulvar sites using two methods, the Food and Drug Administration-approved ViraPap test and polymerase chain reaction (PCR) DNA amplification technology, in 467 women presenting to a university health service for a routine annual gynecologic examination. The PCR system afforded the sensitive detection of a broad spectrum of genital HPV types. Using PCR, we found that 46% of the study population was infected with HPV; the ViraPap test showed a prevalence of 11% infected. PCR analyses demonstrated that 69% of the HPV-positive women were infected at both genital sites. Subsequent HPV-type determination showed that 33% of the study population had HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, or other previously isolated types, and 13% had yet unidentified types. Almost all (92%) of the women diagnosed by Papanicolaou smear with condylomatous atypia or dysplasia (n = 12) were HPV positive. The PCR method proved to be an informative and rapid way to detect HPV in large numbers of clinical samples. Our results demonstrate that genital HPV infection is common among sexually active young women.
Effect of Early Cerebral Magnetic Resonance Imaging on Clinical Decisions in Infective Endocarditis
Authors: Xavier Duval
Journal: Annals of Internal Medicine (2010)

Background: Neurologic complications of endocarditis can influence diagnosis, therapeutic plans, and prognosis. Objective: To describe how early cerebral magnetic resonance imaging (MRI) affects the diagnosis and management of endocarditis in hospitalized adults. Design: Single-center prospective study between June 2005 and October 2008. (ClinicalTrials.gov registration number: NCT00144885) Setting: Tertiary care university hospital in France. Patients: 130 patients with endocarditis. Intervention: Cerebral MRI with angiography performed up to 7 days after admission and before any surgical intervention. Measurements: 2 experts jointly established the endocarditis diagnostic classification (according to Duke-modified criteria) and therapeutic plans just before and after MRI and then compared them. Results: Endocarditis was initially classified as definite in 77 patients and possible in 50 and was excluded in 3. Sixteen patients (12%) had acute neurologic symptoms. Cerebral lesions were detected by MRI in 106 patients (82% [95% CI, 75% to 89%]), including ischemic lesions in 68, microhemorrhages in 74, and silent aneurysms in 10. Solely on the basis of MRI results and excluding microhemorrhages, diagnostic classification of 17 of 53 (32%) cases of nondefinite endocarditis was upgraded to either definite (14 patients) or possible (3 patients). Endocarditis therapeutic plans were modified for 24 (18%) of the 130 patients, including surgical plan modifications for 18 (14%). Overall, early MRI led to modifications of diagnosis or therapeutic plan in 36 patients (28% [CI, 20% to 36%]). Limitation: Investigators did not assess whether the MRI-related changes in diagnosis and therapeutic plans improved patient outcomes or led to unnecessary procedures and increased costs. Conclusion: Cerebral lesions were identified by MRI in many patients with endocarditis but no neurologic symptoms. The MRI findings affected both diagnostic classifications and clinical management plans. Primary Funding Source: French Ministry of Health.
A Patient With a Preexisting (Nontoxic, Nonautonomous) Thyroid Nodule and Concurrent Thyroiditis Mimicking a Toxic Solitary Autonomous Thyroid Nodule on 99mTcO4 Scintigraphy
Authors: Wouter van der Bruggen, Christa van Schaik van de Mheen, Aart H. Mudde
Journal: Clinical Nuclear Medicine (2012)

A 40-year-old patient had been analyzed because of a solitary nodule in the thyroid, including thyroid scintigraphy with 99mTcO4 showing only slightly decreased uptake in the lower right lobe in an otherwise normal thyroid. Five years later, this patient presented with hyperthyroidism and a painful neck. This time thyroid scintigraphy showed single focal uptake in the lower right lobe and suppression of the remaining thyroid tissue, suggesting a toxic solitary autonomous nodule. Clinically, however, the patient was suffering from viral thyroiditis, and she recovered spontaneously. A specific pitfall of thyroid scintigraphy is discussed.
Pre-Excitation as a Cause of Appearance and Increased Intensity of Systolic Murmurs
Authors: JOHN M. BERGLAND, WARREN R. RUCKER, JOHN T. REEVES, BORYS SURAWICZ
Journal: Circulation (1966)

In three patients with a Wolff, Parkinson, White (WPW) pattern and systolic murmur, the murmur disappeared or decreased in intensity when the WPW pattern disappeared or became less pronounced. The accentuation of the murmur of tricuspid and mitral insufficiency suggests that pre-excitation may be responsible for an increase in regurgitant flow in patients with these lesions. A "functional" murmur may appear only during pre-excitation. The appearance or increased intensity of the murmur is presumably related to the altered patterns of ventricular activation and contraction accompanying the WPW pattern.
Sciatic Palsy in Premature Infants
Authors: Paul H. Curtiss
Journal: JAMA (1960)

Ten premature infants with partial sciatic palsy were followed-up for an average period of three years and four months. In all but one patient, recovery of a functional degree of dorsiflexion of the foot occurred in an average of four months. Six patients developed a mild, easily correctable equinovarus deformity, and all but one showed 1 to 2 cm. of shortening of the involved foot. In the absence of other demonstrable causes, the authors concluded that the sciatic nerve lesion originated in an inadvertent injury by an injecting needle or from a neurotoxic effect of the agent injected. The one constant finding in all cases was a history of intramuscular gluteal injections starting on the first day of birth. The ventrogluteal injection site is safer as suggested than the traditional dorsogluteal site.
BONE-MARROW TRANSPLANTATION FOR CHRONIC MYELOGENOUS LEUKAEMIA
Authors: JohnM. Goldman, MortimerM. Bortin, RichardE. Champlin, RogerH. Herzig, PhilipB. Mcglave, HansA. Messner, AlfredA. Rimm, Bruno Speck, RoyS. Weiner
Journal: The Lancet (1985)
Abstract 147: ER-α36 plays an important role in estrogen-dependent growth of gastric cancer cell line BGC823
Authors: Feng Zou, Hao Deng, Hongyan Zhen, Xuming Wang, Lijiang Liu
Journal: Cancer Research (2012)

Abstract Aims: We aimed to investigate the role of estrogen-development signal in growth of gastric cancer cell, and the expression and location change of new estrogen receptor ER-α36 in gastric cancer cell when dealt with estrogen. Methods: Gastric cancer BGC823 was chosen as research model and 17β- estradiol (E2) was used to deal with cell. Cell growth was examined by WST-1 method and assayed by microplate reader. ER-α36 expression in mRNA and protein level was assayed by RT-PCR and Western-blot methods and was quantitated. The location of ER-α36 in cell was examined by immunofluorenscence methods. Result: The cell numbers significantly increased in all E2 treatment groups compared with control group and the number of the cell was more at 48h than 24h in E2 treatment groups (p&amp;lt;0.05), but with E2 concentration increased, cell growth rate slowed down. ER-α36 mRNA expressions of all E2 treatment groups were more than that of control group at 24h and 48h, and had a concentration-dependent of E2 (p&amp;lt;0.05). ER-α36 protein expression had a concentration-dependent of E2 and was less at 48h than 24h in E2 treatment groups (p&amp;lt;0.05). E2 treatment groups’ protein expression were more than control group's at 24h (p&amp;lt;0.05), and were less than control group's at 48h (p&amp;lt;0.05). ER-α36 is localized on the membrane and cytoplasm of BGC823 cell, and its location did not change dealt with E2. Conclusion: E2 could promote the growth of BGC823 cell, and estrogen in different concentration may play different role in the growth regulation of gastric cancer. ER-α36 could response to estrogen-dependent signaling of growth and may transmit it through a membrane-based pathway in gastric cancer. There were regulations in transcription and translation of ER-α36 in gastric cancer. ER-α36 was an important estrogen receptor in gastric cancer and may be a potential predicted marker of gastric cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 147. doi:1538-7445.AM2012-147
Immunization against Diphtheria
Authors: G. Bousfield
Journal: BMJ (1942)

The concern for ensuring the competence of physical therapists subsequent to their entry into the profession led the Missouri Physical Therapy Association to develop a mechanism that could be used both to assess competence and to foster professional growth. A self-assessment system using a multimethod testing scheme was designed and named The Assessment Center. Participation in The Assessment Center enables individuals to assess voluntarily their own practice competence and to use the results of this assessment to plan educational pursuits that may enhance professional growth. The purpose of this article is to describe the structure and operations of The Assessment Center. Proposals for further development of the testing scheme and diffusion of the project9s concept are discussed.
Bilateral diaphragmatic paralysis presenting with orthopnoea and apparent radiological evidence of pulmonary embolism.
Authors: A Nisbet, W Kinnear, M J Ward
Journal: BMJ (1991)

with and budgeted for by social services for private property and by the housing department for council homes, the actual work usually being contracted out privately.For major structural adaptations costing over £500-1000-for example, concrete rampscouncil tenants receive a grant or partial grant from the department of environmental health, whereas those in privately owned property may receive a grant after undergoing a means test.The means test is applied to everyone living in the household.Those who "fail" the means test and pay for the adaptation themselves will have the payment they have made held in their favour should the need arise for an application to be made for a second adaptation in the future.Again, the actual work is contracted out privately.For a publicly used building, such as a church, the council may provide half the cost of a ramp, but local arrangements vary.No value added tax is payable on privately bought ramps if the user is chronically sick or disabled.Ramps and rails provide the keys to accessibility to many disabled people.Their value seems obvious, but evaluation of different types has been scarce.Sweeney et al studied several portable ramps available in the United Kingdom and found that subjects' preferences depended on whether they propelled themselves or were pushed by an attendant, the type of wheelchair, the visual ability of user and attendant, and their social needs.6They advised individual testing by each user of any ramp in the environment in which it would be used before purchase.A visit to the nearest disabled living centre should ensure that the most appropriate purchase is made.
Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination
Authors: Bo Qiao, Priscilla Sugianto, Eileen Fung, Alejandro del-Castillo-Rueda, Maria-Josefa Moran-Jimenez, Tomas Ganz, Elizabeta Nemeth
Journal: Cell Metabolism (2012)
Assiette de fruits et lierre en fleur dans un pot à la rose (Fruit Plate and Flowering Ivy in a Pot With a Rose)
Authors: M. Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
[141] LONG TERM FOLLOW-UP OF LIVER TRANSPLANTATION (OLT) FOR CHOLESTATIC AND AUTOIMMUNE END STAGE LIVER DISEASES
Authors: L. Blasone, S. Fagiuoli, M. Colledan, M. Strazzabosco, M. Lenzi, A. Floreani, P. Burra, U. Cillo, R. Merenda, M.F. Donato, G. Rossi, M. Salizzoni, A. Franchello, M. Rizzetto, G. Pinzello, L. De Carlis, P. Toniutto, E. Andorno
Journal: Journal of Hepatology (2007)
Abstract 3083: Dual-specificity phosphatase-2 (DUSP2) negatively control cyclooxygenase-2 (COX-2) expression in cancer cells
Authors: Shih-Chieh Lin, Shaw-Jenq Tsai
Journal: Cancer Research (2012)

Abstract Cyclooxygenase-2 (COX-2), an inducible form of cyclooxygenase, plays a crucial role in the development of cancer via its enzymatic product, prostaglandin E2 (PGE2). Clinical studies reveal that COX-2 is overexpressed in numerous types of cancers, and is associated with increase of angiogenesis, metastasis, and drug resistance. Although nonsteroidal anti-inflammatory drugs, COX-2 inhibitors, have been used for cancer therapy; they have serious side effects in many aspects. Therefore, to explore the underlying mechanism of COX-2 overexpression during cancer progression is critical for developing more efficient and safer way to block COX-2 function. Previously, we have found that the expression of dual-specificity phosphatase-2 (DUSP2), a MAPK-specific phosphatase, is markedly reduced in many kinds of cancers. Here, we identified that COX-2 was a potential downstream target gene of DUSP2. In vitro studies demonstrate that knockdown of DUSP2 significantly increases COX-2 expression and PGE2 production while overexpression of DUSP2 reduces those in cancer cells. Xenografted mouse study further reveals that levels of DUSP2 are reduced during cancer development, which is inversely correlated with COX-2 expression. Re-expression of DUSP2 during tumor progression inhibits COX-2 expression and suppresses tumor growth while knockdown of DUSP2 increases COX-2 expression and enhances tumor growth. These results implied that COX-2 overexpression was due to loss of DUSP2 expression in cancer. Furthermore, we found that hypoxia represses DUSP2 expression resulting in COX-2 overexpression. Taken together, we have demonstrated for the first time that aberrant expression of COX-2 during tumor development is regulated by hypoxia-mediated DUSP2 downregulation. Our data also suggest that DUSP2 is a good molecular target for cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3083. doi:1538-7445.AM2012-3083
Do-Not-Resuscitate Orders at a Teaching Hospital in Japan
Authors: Asato Fukaura, Hiroki Tazawa, Hiroaki Nakajima, Mitsuru Adachi
Journal: New England Journal of Medicine (1995)

The use of cardiopulmonary resuscitation (CPR) must be considered carefully, especially in the case of terminally ill and elderly patients.13 In Japan, most physicians (96 percent) are aware of do-not-resuscitate (DNR) orders,4 but unlike the situation in other countries,516 there has been comparatively little discussion here of DNR policy.4,17,18 There also seems to be inadequate use of DNR orders. We found, for example, that futile CPR is often performed at the time of death in patients with terminal lung cancer.4 We suspect that the reasons for the futile efforts at resuscitation include the lack of a . . .
Anterior Communicating Artery Aneurysms
Authors: Wylie McKissock
Journal: JAMA (1966)

To the Editor:—  Our first reaction on reading Anterior Communicating Aneurysms: A Rebuttal ( 195 : 115, 1966) was that had Drs. Pool and Colton been in law and  medicine, no reply would be necessary. One cannot rebut the evidence of a careful analysis of a statistically designed study involving 457 cases by presenting one table giving the ages of a miscellany of 68 cases which suggests only that a particular surgeon is the most important prognostic factor!  Drs. Pool and Colton describe their cases as favorable-risk patients, a point made only too obvious by the reasonable surgical results. It is impossible to equate these cases with our Category B series which we specifically designated as not deemed in immediate danger of death from the haemorrhage sustained. No surgeon with unimpaired critical faculties would assume that these groups were similar or that the results of treatment could be compared.  The felony
Quantification of Mitral Regurgitation by the Proximal Convergence Method Using Transesophageal Echocardiography
Authors: Min Pu, Pieter M. Vandervoort, Brian P. Griffin, Dominic Y. Leung, William J. Stewart, Delos M. Cosgrove, James D. Thomas
Journal: Circulation (1995)

Background Proximal flow convergence is a promising method to quantify mitral regurgitation but may overestimate flow when the flow field is constrained. This has not been investigated clinically, nor has a correction factor been validated. Methods and Results Eighty-five patients were studied intraoperatively with transesophageal echocardiography and divided into two groups: central convergence (no constraining wall) and eccentric convergence (at least one constraining wall). Regurgitant stroke volume (RSV) and orifice area (ROA) were calculated by ROA=2π r 2 V a /V p and RSV=ROA×VTI cw , where r and v a are the radius and velocity of the aliasing contour and v p and VTI cw are the peak and integral of regurgitant velocity. In eccentric convergence patients, convergence angle (α) was measured from two-dimensional Doppler color flow maps, and ROA and RSV were corrected by multiplying by α/180. For reference, RSV was the difference between thermodilution and pulsed Doppler stroke volumes. In central convergence patients (n=45), RSV ( r =.95, Δ=2.5±10.8 mL) and ROA ( r =.96, Δ=0.02±0.08 cm 2 ) were accurately calculated, but significant overestimation was noted in the eccentric convergence patients (n=40, ΔRSV=63.9±38.0 mL, ΔROA=0.54±0.31 cm 2 ), 68% of whom had leaflet prolapse or flail. ΔRSV was correlated with α ( r =–.69, P &lt;.001). After correction by α/180, overestimation was largely eliminated (ΔRSV=15.5±19.3 mL and ΔROA=0.14±0.14 cm 2 ) with excellent correlation for the whole group (RSV, r =.91; ROA, r =.95). Conclusions A simple geometric correction factor largely eliminates overestimation caused by flow constraint with the proximal convergence method and should extend the clinical utility of this technique.
Programmed cell death in amyotrophic lateral sclerosis
Authors: Christelle Guégan, Serge Przedborski
Journal: Journal of Clinical Investigation (2003)

Nonstandard abbreviations used: amyotrophic lateral sclerosis (ALS); copper/zinc superoxide dismutase (SOD1); pheochromocytoma-12 (PC-12); programmed cell death (PCD); extracellular signal-regulated kinase (ERK)