tbuckley/cabot-search huggingface dataset:
Cumberland Infirmary, Carlisle: Two Cases of Hemeralopia, Occurring in Cotton-Spinners
Authors: W.B. Page
Journal: BMJ (1846)

The -following case may be interesting to the younger members of our profession, and as it has been satis- factory to we, after reflecting on discussions latelv arising on the management of " placenta prveria," you will, if you, think it worthy, give it rooni in your Journal when convenient.On Tuesday last, the 24th of the nmonth, I was called to Susanna Newton, aged 25, pregniant for the fourth time.At ten a.m.I found the patient had been alarmed by a copious show without labour-pains.I directed her to bed, and on examination found the vagina and uterus little prepared for labour.She -was kept quiet and cool,, and I heard no inore of her tiHl three a.m. of the following day, when I went to her in haste.A. profuse flooding had occurred, with slight pains; I introduced my hand slowly, and with somne difficulty, into the vagina, and found the os uteri dilated to the size of a crown-piece, and a portion of the placenta
EFFECT OF URECHOLINE® ON THE STOMACH, INTESTINE AND URINARY BLADDER
Authors: I. F. STEIN
Journal: JAMA (1949)

Recent interest has been aroused in the drug urecholine®<sup>1</sup>(urethane of beta methylcholine chloride) by the demonstration of the stimulatory action of this drug on gastric motility following complete vagotomy. This action was first reported by Machella 2 and confirmed by Grimson,<sup>3</sup>Stein,<sup>4</sup>Smith<sup>5</sup>and Dragstedt.<sup>6</sup>Starr and Ferguson<sup>7</sup>have reviewed the early literature and have demonstrated the value of urecholine® in postoperative urinary retention. The stimulatory effect of urecholine® on intestinal motility was reported by Youmans 8 and has been further studied experimentally by Postlethwait.<sup>9</sup> <h3>METHOD</h3> The effect of urecholine® on the stomach was studied by means of kymographic tracing of gastric motility as well as clinical observations. A detailed report of the gastric motility studies was previously published.<sup>10</sup> The effect of urecholine® on intestinal motility was studied by clinical observation of patients with adynamic ileus. The effect of urecholine® on
P-selectin inhibition prevents early neutrophil activation but provides only modest protection against myocardial injury in dogs with ischemia and forty-eight hours reperfusion
Authors: Masazumi Arai, Yoshihiro Masui, Pascal Goldschmidt-Clermont, Anthony DiPaula, Cynthia Siu, Takeshi Kondo, Lewis C Becker
Journal: Journal of the American College of Cardiology (1999)

OBJECTIVES This study was designed to determine whether antibody neutralization of the adhesion protein P-selectin would prevent neutrophil activation and reduce myocardial reperfusion injury. BACKGROUND Although inhibition of P-selectin markedly reduces short-term myocardial injury after ischemia and reperfusion, it is unknown whether it can provide meaningful long-term protection and preserve left ventricular function. METHODS Closed-chest dogs underwent 90 min left anterior descending coronary artery occlusion and 48 h reperfusion, and were randomized to 1) a treatment group (n = 11) receiving 1 mg/kg of the blocking anti–P-selectin antibody PB1.3, or 2) a control group receiving 1 mg/kg PNB1.6 (nonblocking antibody against P-selectin, n = 7) or an equivalent volume of saline (n = 2) 10 min before reperfusion. Infarct size was assessed postmortem by triphenyl tetrazolium chloride staining. Contrast left ventriculography was used to measure left ventricular function. Activation of circulating polymorphonuclear neutrophils (PMNs) was assessed by an increase in surface CD18 expression. RESULTS Neutrophil activation was observed at 30 min after reperfusion in the control group, but was abolished in the treatment group. Infarct size was reduced about 25% in the treatment group after controlling for variations in ischemic blood flow (p = 0.003, by analysis of covariance). However, this protective effect was not associated with preservation of blood flow to the ischemic–reperfused myocardium, nor with any improvement in global or regional left ventricular function. CONCLUSIONS The anti–P-selectin antibody PB1.3 prevented early PMN activation, but had only a modest long-term infarct-limiting effect over 48 h reperfusion. Adhesion molecules other than P-selectin may mediate delayed PMN activation and accumulation in reperfused myocardium.
S50. Proffered paper: Complex tumour microenvironment screening platform captures biological responses of cancer therapeutics
Authors: H Layman, J Melrose, W Tang, N Brown, D Nguyen, A Melton, M Polokoff, E Berg, A O'Mahony
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts The tumour microenvironment consists of a heterogeneous population of cancer-associated fibroblasts, leaky vasculature, polarised and suppressed immune cells, and hyperproliferative, transformed and invasive epithelial cells. Capturing the complex phenotypic biology of the tumour
The Mental Health Commission
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1978)

Rosalynn Carter is to mental health as Jacqueline Kennedy was to antiques and Ladybird Johnson to flower beds along the highways.She is in favor of her interest, as they were in favor of theirs. And though the Constitution is silent on the authority to be vested in presidential kin, the reality of the matter is that first ladies are customarily accorded the right to do good — which means that they may exhort freely on matters that do not evoke serious partisan passions.In the current administration, this uxorial custom has now produced its first major product, the Report . . .
THE PAN-AMERICAN MEDICAL CONGRESS.
Authors: Charles A. L. Reed
Journal: JAMA (1892)

The Committee on Permanent Organization met at St. Louis, October 14, 15 and 16, 1891, and adopted a series of General Regulations for the permanent organization of the Pan-American Medical Congress, and a series of special regulations for the government of the first meeting, and recommended that the Incorporators adopt both series of regulations as the organic law of the Congress. Pursuant to such Regulations the following general officers were elected, viz.: William Pepper, M.D.,L.L.D., Philadelphia, Pa., President; Abraham M. Owen, A.M.,M.D., Evansville, Indiana, Treasurer; Charles A. L. Reed, M.D., Cincinnati, Ohio, Secretary General. International Executive Committee: Argentine, Dr. Pedro Lagleyze; Bolivia. Emilio de Tomassi; Brazil, Dr. Carlos Costa; British North America, Dr. James F. W. Ross; British West Indies, Dr. James A. De Wolf; Chili, Dr. Moises Amaral; Colombia, P. M. Ibañez; Costa Rica, Dr.D.Nuñez; Ecuador, Dr. Ricardo Cucalon; Gautemala, Dr. José Monteris; Haiti, Dr. D. Lamothe; Hawaii,-; Spanish
A third case of HOPP syndrome-confirmation of the phenotype
Authors: A.M. Brun, M.A.M. van Steensel
Journal: British Journal of Dermatology (2004)

Journal Article A third case of HOPP syndrome—confirmation of the phenotype Get access A.M. Brun, A.M. Brun Servicio de Dermatología, Hospital Ruiz y Páez, Ciudad Bolívar, Venezuela, and *Dermatology Department, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar M.A.M. Van Steensel M.A.M. Van Steensel Servicio de Dermatología, Hospital Ruiz y Páez, Ciudad Bolívar, Venezuela, and *Dermatology Department, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands M.A.M.van Steensel, E‐mail: mvst@sder.azm.nl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 5, 1 May 2004, Pages 1032–1033, https://doi.org/10.1111/j.1365-2133.2004.05939.x Published: 01 May 2004
Cross-Sectional Associations of Albuminuria and C-Reactive Protein With Functional Disability in Older Adults With Diabetes
Authors: Hsu-Ko Kuo, Soham Al Snih, Yong-Fang Kuo, Mukaila A. Raji
Journal: Diabetes Care (2011)

OBJECTIVE To examine the relationship between albuminuria, inflammation, and disability in older adults with diabetes. RESEARCH DESIGN AND METHODS Data were from 1,729 adults (≥60 years) with diabetes in the National Health and Nutrition Examination Survey, 1999–2008. Disability in activities of daily living (ADL), instrumental activities of daily living (IADL), leisure and social activities (LSA), general physical activities (GPA), and lower-extremity mobility (LEM) was obtained from self-reports. Urinary albumin-to-creatinine ratio (UACR) (mg/g) was categorized into normal (UACR &amp;lt;30 mg/g), microalbuminuria (UACR 30–300 mg/g), and macroalbuminuria (UACR &amp;gt;300 mg/g). C-reactive protein (CRP) levels were quantified by latex-enhanced nephelometry. RESULTS In the full-adjusted model, microalbuminuria was associated with disability in ADL, LSA, and LEM with corresponding odds ratios (ORs) (95% CIs) of 1.51 (1.16–1.98), 1.62 (1.23–2.14), and 1.34 (1.03–1.74), respectively, compared with participants without albuminuria. Macroalbuminuria was associated with disability in ADL, IADL, and LEM with corresponding ORs (95% CIs) of 1.94 (1.24–3.03), 1.93 (1.23–3.02), and 2.20 (1.38–3.49), respectively, compared with participants without albuminuria. Elevated CRP (&amp;gt;0.3 mg/dL) was associated with increased odds of disability in ADL and LEM, with corresponding ORs (95% CIs) of 1.28 (1.00–1.62) and 1.68 (1.34–2.11), respectively. Subjects with both albuminuria and elevated CRP had higher odds of disability than individuals with no albuminuria and normal CRP. CONCLUSIONS Albuminuria and inflammation were independent correlates for disability among older adults with diabetes. There was an interaction of albuminuria and elevated CRP on disability, suggesting that the presence of subclinical inflammation may amplify the effect of albuminuria on disability in older adults living with diabetes.
Kinetic studies on MSH and α2-adrenoceptor interaction on the Anolis melanophore
Authors: R. J. CARTER, SAM SHUSTER
Journal: British Journal of Dermatology (1982)

Journal Article Kinetic studies on MSH and α2‐adrenoceptor interaction on the Anolis melanophore Get access R. J. CARTER, R. J. CARTER Department of Dermatology, University of Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar SAM SHUSTER SAM SHUSTER Department of Dermatology, University of Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue s23, 1 November 1982, Pages 134–139, https://doi.org/10.1111/j.1365-2133.1982.tb01045.x Published: 01 November 1982
The toxicity of certain cereal proteins in coeliac disease
Authors: H. J. Cornell, R. R. W. Townley
Journal: Gut (1974)

Gliadins from wheat, rye, and oats, and from wheat glutenin were digested with pepsin, trypsin, and pancreatin and the products (PTC digests) chromatographed on sulphopropyl (SP) Sephadex. Fractions eluted near neutral pH from wheat, rye, and oats gliadin digests all had very similar amino acid composition, although the oats fraction was higher in sulphur-containing amino acids. The major amino acids present in all were glutamine/glutamic acid and proline. The amount of fraction eluted near neutral pH from oats gliadin digest was about 13% of that eluted from digests of wheat and rye gliadins. Moreover, the yield of gliadin from oatmeal was only 0.5% compared with 2.4% and 2.8% from rye and wheat flours respectively. The amount of fraction eluted from wheat glutenin digest was about 70% of that obtained from wheat and rye gliadin digests. The fractions eluted near neutral pH from all protein digests were defectively digested by remission coeliac mucosa, and D-xylose excretion tests with the fraction from the wheat gliadin digest (fraction 9) indicated that it is harmful to subjects with coeliac disease, whereas the other fractions of this digest gave no such evidence. The results of the present work indicate that counterpart fractions to fraction 9 obtained from wheat glutenin and rye and oats gliadins may also be important in the aetiology of coeliac disease.
Angiomyofibroblastoma of the vulva with a penile appearance
Authors: T. Watanabe, Y. Yoshida, O. Yamamoto
Journal: British Journal of Dermatology (2007)

Journal Article Angiomyofibroblastoma of the vulva with a penile appearance Get access T. Watanabe, T. Watanabe Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, 86 Nishi‐cho, Yonago 683‐8503, Japan E‐mail: tessin@grape.med.tottori‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Y. Yoshida, Y. Yoshida Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, 86 Nishi‐cho, Yonago 683‐8503, Japan E‐mail: tessin@grape.med.tottori‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar O. Yamamoto O. Yamamoto Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, 86 Nishi‐cho, Yonago 683‐8503, Japan E‐mail: tessin@grape.med.tottori‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 1, 1 July 2007, Pages 189–191, https://doi.org/10.1111/j.1365-2133.2007.07929.x Published: 01 July 2007
Insulin Treatment of Schizophrenia in Wartime
Authors: J. S. McGregor, R. A. Sandison
Journal: BMJ (1940)

may therefore be assumed that his heart was normal before the accident.Condition on Examination.-Thepatient was pale but not distressed.There were some abrasions and a slight swelling in the precordial region.The cardiac impulse was weak and there was a faint systolic thrill to be felt over the fourth intercostal space just to the left of the sternum.The apex beat was situated one-quarter of an inch internal to the nipple line in the fifth space.The area of cardiac dullness was not enlarged.There was a very loud blowing systolic murmur audible all over the praecordium and conducted round to the left base.It was maximum in the fourth space just to the left of the sternum.No second sound was audible except in the pulmonary area, where it could just be detected.The pulse was regular, 92 per minute, and of poor value, the blood pressure being 88/74.The klngs were clear.The electrocardiogram showed the RS-T complex elevated above the base line in all three leads-the elevation being maximum in Lead II-and a deep Q wave and inverted T wave in Lead III.He was kept at complete rest in bed and was given tab.digitalis folia 1/2 grain t.d.s.During the following week he ran a slight irregular temperature and had some cough.On April 21 the signs in the heart were unchanged, but the blood pressure had risen to 114/76.There was an area of impaired percussion note and diminished air entry at the right base and rales were heard at both bases.The liver edge could be felt one inch below the right lower costal margin in the nipple line, but there was no oedema.The electrocardiogram now showed that T, was of low voltage and that T2 was becoming inverted.The dose of digitalis was increased to 1 grain t.d.s.
USE OF CONTRAINDICATED ANTITHROMBOTIC MEDICATIONS IN THE CARDIAC CATHETERIZATION LABORATORY: INSIGHTS FROM THE VETERANS AFFAIRS CLINICAL ASSESSMENT, REPORTING, AND TRACKING PROGRAM
Authors: Geoffrey D. Barnes, Maggie Stanislawski, Anna E. Baron, Ehrin Armstrong, P. Michael Ho, Andrew Klein, Thomas Maddox, Brahmajee Nallamothu, John Rumsfeld, Thomas Tsai, Steven Bradley
Journal: Journal of the American College of Cardiology (2015)
Book Review The Costs of Poor Health Habits By Willard G. Manning, Emmett B. Keeler, Joseph P. Newhouse, Elizabeth M. Sloss, and Jeffrey Wasserman. 223 pp. Cambridge, Mass., Harvard University Press, 1991. $29.95. ISBN 0–674–17485–2 .
Authors: Frank A. Sloan
Journal: New England Journal of Medicine (1992)
Women doctors in urban general practice
Authors: C M Richards, N R Nutt, W. Coe, A. Wheeler
Journal: BMJ (1985)

not given the impression that this would be a welcome development.Although the radio- grapher did issue a report during the study, the system as it operates at Ealing and North- wick Park hospitals merely entails the radio- grapher placing a marker on the film packet if concerned about possible abnormality.
Phase I Trial of Weekly Docetaxel With Concurrent Three-Dimensional Conformal Radiation Therapy in the Treatment of Unfavorable Localized Adenocarcinoma of the Prostate
Authors: Parvesh Kumar, Michael Perrotti, Robert Weiss, Mary Todd, Susan Goodin, Kenneth Cummings, Robert S. DiPaola
Journal: Journal of Clinical Oncology (2004)

A phase I trial was conducted to determine the maximally tolerated dose (MTD) of concurrent weekly docetaxel and three-dimensional conformal radiation therapy (3-D CRT) in unfavorable localized adenocarcinoma of the prostate.Patients with unfavorable localized adenocarcinoma of the prostate underwent daily 3-D CRT to a total dose of 70.2 Gy at 1.8 Gy/fraction and concurrent docetaxel given once a week for 8 to 9 weeks. The initial weekly docetaxel dose level was 5 mg/m(2) and the docetaxel doses were escalated as follows: 8, 12, 16, 20, and 25 mg/m(2).Between January 2000 and August 2002, 22 men completed the chemoradiation therapy protocol. The dose-limiting toxicity was grade 3 diarrhea, which occurred in the first two patients treated at the 25 mg/m(2) docetaxel dose level. The MTD of weekly docetaxel was determined to be 20 mg/m(2). The overall incidence of grade 2 diarrhea and grade 2 dysuria was 36% and 23%, respectively. Seven (32%) and 15 (68%) patients did not experience any diarrhea or dysuria, respectively. No neutropenia or thrombocytopenia was observed. One patient required intermittent urinary catheterization 10 months postcompletion of therapy, which resolved without any surgical intervention. Seventeen patients remain in prostate-specific antigen remission. At a median follow-up interval of 8 months (range, 2 to 27 months), all patients are alive.Concurrent weekly docetaxel in conjunction with 3-D CRT is well tolerated with acceptable toxicity. The MTD of weekly docetaxel was determined to be 20 mg/m(2) with concurrent 3-D CRT.
Acute haemolysis due to concentrated dialysis fluid.
Authors: I Mulligan, P Parfrey, M E Phillips, E A Brown, J R Curtis
Journal: BMJ (1982)

Fatal acute haemolysis occurred in a 65-year-old man undergoing regular home haemodialysis for terminal renal failure. Circumstantial evidence indicating that the haemolysis resulted from exposure to concentrated dialysis solution was supported by in-vitro studies. Frank haemolysis in blood samples occurred at a dilution of greater than or equal to 1/2 of dialysis fluid. Osmotic fragility tests of surviving red blood cells showed 47% haemolysis at a dilution of 1/2 and greater than 90% haemolysis at a dilution of 1/1. Urgent design modifications to the proportionating machine are being undertaken to prevent such an accident recurring.
THE FRACTIONAL FLOW RESERVE-GUIDED SYNTAX SCORE FOR RISK ASSESSMENT IN MULTI-VESSEL CORONARY ARTERY DISEASE
Authors: Chang-Wook Nam, Fabio Mangiacapra, Robert Entjes, In-Sung Chung, Pim A.L. Tonino, Bernard De Bruyne, Nico H.J. Pijls, William F. Fearon
Journal: Journal of the American College of Cardiology (2011)
Cigarette Vending Machines
Authors: M. Goldman
Journal: BMJ (1971)

suggest that from the standpoint of long- term forward planning it may be the correct one, and it is noteworthy that in my ex- perience visitors from other countries are usually full of admiration for the general standard of care offered to all psychiatric in- patients in Britain.You refer to the paper by Anthea M. Hailey2 based on the Camberwell Register.She states that the composition of the long- stay group which she studied is changing and that the group is being replaced in part by "a large number of psycho-geriatric patients."She adds: ". . .elderly patients contribute half the new long-stay build- up . .."Yet when Mrs. Hailey concludes by asking whether present trends of care are in the right direction you appear, in effect, to support the view that it is correct for increasing numbers of the elderly confused to be accommodated in mental hospitals.I would join issue with this implication.At another point in her paper Mrs. Hailey states that ". . .hospital policies differ and the constitution of a long-stay group at any one time depends both on this and on avail- ability of alternative services in the locality."This is indeed true and, for example, one cannot help but notice that in the general
Diagnosis With Wood's Light
Authors: Kenneth M. Halprin
Journal: JAMA (1967)

For less than $100 any one can own a Wood's light; yet this diagnostic tool is not standard equipment in the physician's office. A Wood's light produces long-wave ultraviolet light with a maximum at a wavelength of 3,600 Angstrom units (by comparison, the sunburn range is 2,800 to 3,200 A, and visible light is greater than 4,000 A). Some chemical substances which absorb long-wave ultraviolet light will be excited by this lamp to emit light of a longer (visible) wavelength. When viewed under a Wood's light in a dark room, the substance will appear to have a characteristic color depending upon the wavelength of the emitted (fluorescent) light. The use of this fluorescence in the office diagnosis of several diseases will be discussed in this and the succeeding communication. The examination of the scalp of children for the presence of ringworm (tinea capitis) with the Wood's light is a simple,
Distal myocardial protection with intracoronary propranolol during percutaneous coronary intervention is widely applicable
Authors: Fen Wei Wang, Abdulfath Osman, Javier Otero, George A. Stouffer, Sergio Waxman, Adnan Afzal, Angelo Anzuini, Barry F. Uretsky
Journal: Journal of the American College of Cardiology (2003)
Mass peristalsis in the human colon after contact with oxyphenisatin
Authors: J. Ritchie
Journal: Gut (1972)

Colonic motility studies using time-lapse cinefluorography and intraluminal pressure recording before and after the introduction per rectum of a mixture of barium sulphate and oxyphenisatin solution show the different forms of movement of the colonic contents. Oxyphenisatin was found to be a selective actuator of a form of progressive mass propulsion indistinguishable from spontaneous mass peristalsis. Less than 0.5 mg distributed through the pelvic and distal descending colon was enough to produce a peristaltic response; larger quantities tended to increase the number of resulting movements.A standard dose of 4 mg of the drug was followed by mass peristalsis in 82% of the subjects in whom it came into adequate contact with colonic mucosa. The response usually took place within 20 minutes. The more sensitive the subject, the greater was the number of peristaltic responses and the shorter the interval before the response began. In 73% of the subjects who responded, the mass peristalsis came to a halt between 40 and 25 cm from the anal margin, and many of those in whom it extended farther appeared to have shortened distal colons. The likelihood of the drug giving rise to peristalsis diminished abruptly distal to about 45 cm from the anus; its effectiveness was greatest in the proximal descending colon.
GW25-e0735 Role of Wnt4/Dvl-1/ß-Catenin Signal Pathway in Balloon-Injured Carotid Artery Restenosis
Authors: Hua Junyi, Xu Yun, Jiang Xuhong, He Yuzhou, Ye Wu, Pan Zhimin
Journal: Journal of the American College of Cardiology (2014)