tbuckley/cabot-search huggingface dataset:
Five Year Study of Simultaneous Antimetabolites and Alkylating Agents in the Chemotherapy of Advanced Breast Carcinoma.
Authors: Ezra M. Greenspan
Journal: Annals of Internal Medicine (1965)

s1 May 1965Five Year Study of Simultaneous Antimetabolites and Alkylating Agents in the Chemotherapy of Advanced Breast Carcinoma.Ezra M. Greenspan, M.D., F.A.C.P.Ezra M. Greenspan, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1093_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNinety-eight patients with multifocal metastatic breast carcinoma were treated with simultaneous combinations of thio-triethylenephosphoramide (TEPA) plus methotrexate (TP + MTX), cyclophosphamide (Cytoxan®) (Cyt) plus 5 fluorouracil (FU), TP + MTX + FU, or Cyt + MTX + FU. Maintenance alkylating agent (Alk) therapy (TP or Cyt) and intermittent courses of metabolic inhibitors (MTX or 5 FU) were given for 1 to 2 years. Central nervous system (CNS), hepatic, and diffuse preterminal disseminated metastases were also treated with moderate prednisone dosage. Hematostimulative supportive therapy included aqueous crystalline testosterone to masculinization, and monthly vitamin B12.In a first group of 40 androgen-resistant... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Ezra M. Greenspan, M.D., F.A.C.P.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1093-1093KeywordsBreast cancerCentral nervous systemChemotherapeutic agentsChemotherapyCyclophosphamideMethotrexateTestosterone ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...
Leukemia Following Radioiodine Therapy of Hyperthyroidism
Authors: Sidney C. Werner
Journal: JAMA (1961)

POCHIN has recently analyzed the incidence of leukemia in patients previously given I<sup>131</sup>(an internal source of beta and gamma rays) for the therapy of hyperthyroidism.<sup>1</sup>The data were collected by questionnaire from those clinics in Great Britain which used the isotope therapeutically. Information was included which had been assembled by others in several additional countries where I<sup>131</sup>therapy is extensively employed. Eighteen cases of leukemia in hyperthyroid patients previously treated with I<sup>131</sup>were collected through May, 1960. Three cases were also recorded in which the onset of leukemia had preceded I<sup>131</sup>therapy and which might erroneously have been considered to have followed I<sup>131</sup>therapy had not a preliminary blood count been performed. Pochin concluded, "The present evidence, while giving no support to the idea that leukemia is induced by the radioiodine treatment of thyrotoxicosis, neither excludes such induction nor sets any upper
VITAMINS AND DISORDERS OF THE SKIN*
Authors: GODFREY BAMBER
Journal: British Journal of Dermatology (1942)

Journal Article VITAMINS AND DISORDERS OF THE SKIN Get access GODFREY BAMBER GODFREY BAMBER Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 54, Issue 6, 1 June 1942, Pages 163–173, https://doi.org/10.1111/j.1365-2133.1942.tb10667.x Published: 01 June 1942
Principles and Practice of Medical Therapy in Pregnancy
Authors: Edwin M. Gold
Journal: JAMA (1992)

This second edition of<i>Principles and Practice of Medical Therapy in Pregnancy</i>appears a scant six years after the first. I reviewed it then as probably the most complete compilation of therapy for medical conditions complicating pregnancy extant. Now, rewritten and updated, it continues as a truly extraordinary textbook of medicine developed expressly for both practicing obstetricians and internists. All organ systems and their relevant diseases affecting mother and fetus are discussed in depth, and each chapter presents an extensive bibliography updated in many instances to 1990. Edited by Dr Gleicher with the able assistance of five section editors, this is a volume of 1362 pages, with 213 chapters by 206 contributors, of whom 107 are obstetric specialists and 99 specialists in a wide variety of medical fields. Despite the diversity of authorship, the text is homogeneous in style, reader friendly, and therapeutically informative. Of particular merit are the sections
Serious Adverse Drug Effects — Seeing the Trees through the Forest
Authors: Jerry H. Gurwitz
Journal: New England Journal of Medicine (2006)

The medical community and the public have been buffeted by a steady stream of news linking the use of widely prescribed medications with serious health risks. The latest in this barrage of unsettling reports is an article by Park-Wyllie et al. that appears elsewhere in this issue of the Journal 1 regarding the association of the fluoroquinolone gatifloxacin with dysglycemia.The authors describe the findings of two population-based, nested case–control studies involving outpatients 66 years of age or older who had received treatment with various broad-spectrum antibiotics. The first study demonstrated a substantial increase in the risk of emergency department treatment . . .
Reaction to Tolmetin Explained
Authors: Nile R. Clark
Journal: JAMA (1980)

ABSTRACT To the Editor.— McCall and Cooper reported on an emergency room patient who experienced what was described as an anaphylactoid reaction to tolmetin sodium (243:1263, 1980). When I learned to my surprise that the case described was, in fact, that of a man who had been my patient for some time, I reviewed my records, and those of the emergency room, and talked with the patient concerning the incident. Since the actual events differed in several important respects from the report printed in JAMA, I feel compelled to set the record straight.Early in 1978, after the patient had been taking tolmetin intermittently for about five months with good results, he experienced a mild allergic reaction characterized by rash, and face and arm swelling; he had no respiratory distress. He presented himself to the emergency room and was treated intramuscularly with diphenhydramine hydrochloride (Benadryl) and dexamethasone. Recovery was uneventful. A
Transmission of psoriasis by allogeneic bone marrow transplantation and blood transfusion
Authors: X Li, J Li, L Wang, X Niu, R Hou, R Liu, Z Hao, C Wang, G Yin, K Zhang
Journal: Blood Cancer Journal (2015)

Psoriasis is an immune-mediated dermatological disease, with T-cells have an important role in its pathogenesis.Activated CD4 + and CD8 + lymphocytes infiltrate the dermis and epidermis, resulting in hyperkeratosis, parakeratosis, epidermal acanthosis, elongation of the rete ridges and vascular dilatation.Before allogeneic bone marrow transplantation (BMT), the immune system of the host is effectively eliminated by a preconditioning regimen, and any immune response after BMT is typically of donor origin. 1,2In the past 25 years, 430 patients with psoriasis who underwent BMT and subsequently achieved long-term remission of psoriasis have been reported in the literature. 3,46][7] We report two additional cases of patients who developed psoriasis after blood transfusion or allogeneic BMT.
The CMS Ruling on Venous Thromboembolism After Total Knee or Hip Arthroplasty
Authors: Michael B. Streiff
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
It's a Boy!
Authors: Hope K. Haefner
Journal: Annals of Internal Medicine (1994)

On Being a Doctor1 May 1994It's a Boy!Hope K. Haefner, MDHope K. Haefner, MDUniversity of Michigan Medical Center, Ann Arbor, MI 48109-0718.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-9-199405010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail One morning I did a repeated low-transverse cesarean section and delivered a healthy, 8-pound 13-ounce, male infant. Although deliveries are always exciting, this one had a deeper, more personal meaning. Three years before this cesarean section, few anticipated my ability to ever do surgery again.My problems started abruptly, on 14 December 1985, with a sweet unpleasant odor. I thought it was from the infant I was examining during a neonatology internship rotation, a requirement at that time for obstetric and gynecology residents. The nurse assured me that there was no foul odor, but I knew better. Rather than debate ... Author, Article, and Disclosure InformationAuthors: Hope K. Haefner, MDAffiliations: University of Michigan Medical Center, Ann Arbor, MI 48109-0718.Corresponding Author: Hope K. Haefner, MD, Division of Gynecology, Medical Professional Building D2202-0718, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0718. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1994Volume 120, Issue 9Page: 806KeywordsCesarean sectionFatigueInfantsMigraineResidencySleepSmellSurgeryTemporal lobeVomiting ePublished: 15 August 2000 Issue Published: 1 May 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Survival differences after stroke in a multiethnic population: follow-up study with the south London stroke register
Authors: Charles D A Wolfe, Nigel C Smeeton, Catherine Coshall, Kate Tilling, Anthony G Rudd
Journal: BMJ (2005)

<h3>Abstract</h3> <b>Objectives</b> To identify ethnic differences in survival after stroke and examine the factors that influence survival. <b>Design</b> Population based stroke register with follow-up. <b>Settings</b> South London stroke register. <b>Participants</b> 2321 patients with first stroke registered between January 1995 and December 2002. <b>Main outcome measures</b> Sociodemographic factors, risk factors for stroke and their management, severity of stroke, and acute service provision factors. Survival analysis with Kaplan-Meier curves, log rank test, and Cox9s proportional hazard model with stratification. <b>Results</b> In univariable analyses of survival, outcome was better for black people than white people (median 33.7 <i>v</i> 20.0 months). After stratification by socioeconomic status, type of stroke, and Glasgow coma score, and adjustment for other potential confounders, being black was generally associated with better survival, taking into account the interaction between ethnicity and age, and ethnicity and prior Barthel score. Of the risk factors for stroke considered, current smoking (hazard ratio 1.21, 95% confidence interval 1.01 to 1.45, P = 0.044), untreated atrial fibrillation (1.36, 1.08 to 1.72, P = 0.009), untreated diabetes (1.53, 1.05 to 2.22, P = 0.027), and treated diabetes (1.61, 1.27 to 2.03, P &lt; 0.001) were associated with reduced survival. <b>Conclusion</b> In general, black patients in a south London population with first ever stroke are more likely to survive than white patients, the exceptions being in those aged &lt; 65 and those with a prior Barthel score &lt; 15. Some pre-stroke risk factors that have the potential to be modified, including the appropriate treatment of existing health problems, have a strong impact on survival.
Hazardous air pollutants and asthma.
Authors: George D Leikauf
Journal: Environmental Health Perspectives (2002)

Asthma has a high prevalence in the United States, and persons with asthma may be at added risk from the adverse effects of hazardous air pollutants (HAPs). Complex mixtures (fine particulate matter and tobacco smoke) have been associated with respiratory symptoms and hospital admissions for asthma. The toxic ingredients of these mixtures are HAPs, but whether ambient HAP exposures can induce asthma remains unclear. Certain HAPs are occupational asthmagens, whereas others may act as adjuncts during sensitization. HAPs may exacerbate asthma because, once sensitized, individuals can respond to remarkably low concentrations, and irritants lower the bronchoconstrictive threshold to respiratory antigens. Adverse responses after ambient exposures to complex mixtures often occur at concentrations below those producing effects in controlled human exposures to a single compound. In addition, certain HAPs that have been associated with asthma in occupational settings may interact with criteria pollutants in ambient air to exacerbate asthma. Based on these observations and past experience with 188 HAPs, a list of 19 compounds that could have the highest impact on the induction or exacerbation of asthma was developed. Nine additional compounds were identified that might exacerbate asthma based on their irritancy, respirability, or ability to react with biological macromolecules. Although the ambient levels of these 28 compounds are largely unknown, estimated exposures from emissions inventories and limited air monitoring suggest that aldehydes (especially acrolein and formaldehyde) and metals (especially nickel and chromium compounds) may have possible health risk indices sufficient for additional attention. Recommendations for research are presented regarding exposure monitoring and evaluation of biologic mechanisms controlling how these substances induce and exacerbate asthma.
Blood Volume Determination, A Nuclear Medicine Test in Evolution
Authors: Donald Margouleff
Journal: Clinical Nuclear Medicine (2013)

The method for determining blood volume has evolved substantially since first attempts were made in the latter part of the nineteenth century with the exsanguination of animals. The now accepted methods are based on indicator dilution methodologies. First attempts utilized inert dyes such as Evans Blue and Cardiogreen. These were found to be impractical due, primarily, to their rapid clearance from the blood. For many years, the most accepted method for blood volume determination was the dual isotope technique. This procedure utilizes chromium 51 or 99mTc to label autologous red cells and radioiodine 125 or 131 to label human serum albumin (HSA). Plasma and red cell volumes are measured separately and the results "combined". The procedure requires on-site labeling of autologous red cells and HSA, and meticulous preparation of standards and doses. The complexity of this method leads to performance times of 6 to 8 hours. An FDA-approved single isotope method is now employed in over 60 major institutions. HSA is labeled with radioiodine 131 at an FDA radiopharmaceutical facility, and test doses and standards are provided to laboratories in kit form. The red cell volume is derived by a calculation utilizing the measured plasma volume and the value for the average whole-body hematocrit. All calculations are carried out by a dedicated microprocessor, and a final report is generated and printed. The results are compared with predicted normal values for male and female patients based on percentage deviation from normal weight. Preliminary results are available in 30 minutes and complete calculations in 90 minutes.
Hyposplenism in gastrointestinal disease.
Authors: A F Muller, P J Toghill
Journal: Gut (1995)

Leading article Hyposplenism in gastrointestinal diseaseThe hazards of living without a spleen were recognised by paediatricians in the early 1960s when they focused attention on the syndrome of fulminant sepsis occurring within the first two years of splenectomy.'We now
TWO CASES OF ACUTE SYPHILITIC APPENDICITIS
Authors: G. Evans, E. Rowlands
Journal: BMJ (1930)

ACUTE SYPHILITIC APPENDICITIS.normal.The lower half was replaced bv a cvst.A calculus about three-quarters of an inch long by half an inch wide was felt in the pelvis, The kidney was removed.Report on Kidn7ey and Cyst aftcr Removal.Fig. 4 is a skiagram of the specimen.The calculus is clearly slhown.No connexion between the pelvis of the kidney and the cyst could be demonstrated.It would appear that the stone and cyst were independent of each other.The calculus was composed of pure uric acid.Post-operatire Progress.-Thepatient made an uneventful recovery.When seen on October 11th he was feeling well, putting on weight, and had no urinary symptoms.The urine was normnal in colour, acid, clear, specific gravity 1018; no albumin, nio sugar; urea 2 per cent.; there was a deposit of mucus.The centrifuged deposit showed an occasional pus cell, sonie epithelial cells, and phosphate crystals.No organisms were seen.Cultures were sterile.CONCLUSIONs. 1.The passage of a ureteric catheter to the pelvis of the
Considering effect of liquids use on cortisol stressing hormones, epinephrine and norepinephrine while long time in hot weather
Authors: Mohammad Sajjadian, Hossein Shiasy, Seyed Ziae Moeini
Journal: British Journal of Sports Medicine (2010)

To study effect of liquids use on cortisol stressing while long time (90 min) practice in hot weather is the main purpose of this research. In this research, two arbitrary groups of students in football team at Islamic Azad University of Shoushtar were selected and tested namely test and control groups. The applied effect of eating carbohydrates while 90 min practice of bicycle riding in minutes of 26, 56 and 86 in test groups is studied; of course it was wanted from each group to control their diet. The applied results were analysed with SPSS and the main theoretical result is that using carbohydrate liquids while long time practicing in hot weather on football players has positive effect that should be valued in feeding diet of coaches.
ALCOHOL AS A CAUSATIVE FACTOR IN DISEASES OF THE CENTRAL NERVOUS SYSTEM.
Authors: T. D. CROTHERS
Journal: JAMA (1898)

Next to syphilis, alcohol is the most frequent cause of diseases of the brain. In many instances it is more virulent, rapid and pronounced in its effects and is now fully recognized as a poison of the narcotic class. Its general action on the system is seen in irritation, deranged functional activities, diminished force and narcosis. Some instances show marked narcosis from the beginning. The first effect of alcohol is to produce functional disturbance, and such poisons are called narcotic and neurotic, because their most conspicuous action is on the nervous system. Apparently this effect is transient, and the injury is supposed to be indicated by the repetition of the functional disturbances. A fatal dose acts like other tissue poisons, producing narcosis and necrosis. Alcohol while being carried to all parts of the body acts, like other poisons, on those parts which it reaches with the least amount of dilution,
Surgical treatment of primary hyperparathyroidism in the elderly.
Authors: D A Heath, A D Wright, A D Barnes, G D Oates, N J Dorricott
Journal: BMJ (1980)

Twelve patients aged over 70 with primary hyperparathyroidism (persistent hypercalcaemia and raised serum parathyroid hormone concentrations) underwent parathyroidectomy, which was well tolerated by all. After operation serum calcium concentrations returned to normal and the commonest symptoms before operation (muscle weakness, malaise, and mild to severe dementia), although not related in severity to the degree of hypercalcaemia, improved. Mental function was greatly improved. The findings suggest that primary hyperparathyroidism should be sought in any elderly patient with hypercalcaemia and that more such patients with the diagnosis should be considered for parathyroidectomy irrespective of age.
"THE DANGER OF PITUITARY EXTRACT"
Authors: Charles C. Haskell
Journal: JAMA (1923)

To the Editor:  —Through an abstract that appeared inThe Journal(May 12, 1923, p. 1418) our attention has been directed to the article of Pouliot and Truchard, criticizing our article: The Dangers of Pituitary Extract (The Journal, May 21, 1921, p. 1390). Unfortunately, we have not yet been able to secure a copy of the journal containing Pouliot and Truchard's paper; but, assuming that the abstract correctly represents it, we feel that the statements contained in it create an incorrect impression and should not be passed unchallenged.  In the abstract, it appears that the entire basis for the criticism of Pouliot and Truchard consists of the inadequacy of our case reports of clinical rupture of the uterus following the employment of pituitary solution. As a matter of fact, the mention of such cases in our paper was merely incidental, and constituted only a portion of the argument against the
Ramifications of adverse events in children in Australia
Authors: P. Collignon, P. Doshi, T. Jefferson
Journal: BMJ (2010)

Many serious adverse reactions to this year’s seasonal influenza vaccine have occurred across Australia, and its use remains suspended in children aged 5 years and under.1 2 3 Data released on 1 June 2010 show that 1 in every 110 young children vaccinated with the CSL vaccine had a febrile seizure.3

A previous H1N1 vaccine study published earlier this year showed that a …
Methylphenidate interaction with both anticonvulsants and ethyl biscoumacetate
Authors: L. K. Garrettson
Journal: JAMA (1969)

Therapeutic doses of methylphenidate hydrochloride, given for the minimal cerebral dysfunction syndrome, were found to raise the serum levels of primidone, diphenylhydantoin sodium, and phenobarbital in a child. In this patient, diphenylhydantoin levels rose from therapeutic to toxic levels and ataxia was produced. To explain this apparent inhibition of drug metabolism, experiments in four adult male volunteers were performed. Methylphenidate slowed the rate of disappearance of ethyl biscoumacetate from the serum. This suggests that enhanced anticoagulant action may occur in the presence of methylphenidate.
William Muir Connell Thomas Galla Mervin Glasser Charles Guy Pantin Syed Karamat Husain Zaidi
Authors: J. Connell
Journal: BMJ (2001)

After graduation he served in the Royal Air Force Volunteer Reserve as a medical officer.He entered general practice in Kilburnie and Glengarnock in 1948, and served the community of the Garnock Valley for the next 35 years despite advancing deafness.He was an
Spontaneous pneumothorax: Authors' reply
Authors: D. Seaton, K. Yoganathan, T. Coady, R. Barker
Journal: BMJ (1991)

treated initially by aspiration,' but their conclusion that the "finding of no pleural leak should avoid unnecessary tube drainage and permit early dis- charge, whereas had these patients been treated with an intercostal drain from the outset their hospital stay would inevitably be prolonged" is clearly not sufficient justification to purchase a flame ioniser as they suggest.Few people would drain all these patients from the outset-a trial aspiration followed by repeat radiograph the next day if the lung re-expanded would be more usual.