tbuckley/cabot-search huggingface dataset:
"THE MATERNITY WARD OF THE GENERAL HOSPITAL"
Authors: Rudolph W. Holmes
Journal: JAMA (1933)

<h3>To the Editor:</h3> —The contribution of Drs. DeLee and Siedentopf inThe Journal, January 7, offers irrefutable evidence of the fact that institutional care of parturients is accompanied by an increased incidence of morbidity and mortality over that of the community as a whole. They ignore the fact that practically all hospitals, whether they are called "general" or are conducted for some special field of medicine or obstetrics, are subject to the same laws of human necessity—the really sick enter them—therefore, the mortality rate is higher than for the community as a whole. When the specific cause of a disease is known (as diphtheria, varicella or tetanus), many influences operate to affect the incidence and virulence of the malady: the virulence of the bacterium, the resistance—immunity—of the individual, regional conditions, social and economic environment, climate, food and water supply, each has its weight. In such a complex problem as puerperal
Implementation of Mobile Health Tools
Authors: Kit Huckvale, Josip Car
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poor Patient Adherence May Undermine Aim of Continuous Glucose Monitoring
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RNAi screening of the kinome with cytarabine in leukemias
Authors: Raoul Tibes, James M. Bogenberger, Leena Chaudhuri, R. Tanner Hagelstrom, Donald Chow, Megan E. Buechel, Irma M. Gonzales, Tim Demuth, James Slack, Ruben A. Mesa, Esteban Braggio, Hongwei H. Yin, Shilpi Arora, David O. Azorsa
Journal: Blood (2012)
Trust and mistrust
Authors: N Mamode
Journal: BMJ (1994)

The hospital might close this week. At least, one of the largest and oldest clinical institutions in the country may soon only accept patients with life threatening conditions. Just three weeks since acquiring trust status and the start of the financial year, this is not another case of an empty purse, shoulders shrugged, and operations cancelled, but a decision by the porters, after weeks of vacillation, to finally hold a strike ballot. Threats by union leaders, widely reported by the local media, to close the hospital may be no more than political hyperbole, with a weather eye cast …
The PPAR-RXR Transcriptional Complex in the Vasculature
Authors: Jorge Plutzky
Journal: Circulation Research (2011)

The peroxisome proliferator-activated receptors (PPARs) and the retinoid X receptors (RXRs) are ligand-activated transcription factors that coordinately regulate gene expression. This PPAR-RXR transcriptional complex plays a critical role in energy balance, including triglyceride metabolism, fatty acid handling and storage, and glucose homeostasis: processes whose dysregulation characterize obesity, diabetes, and atherosclerosis. PPARs and RXRs are also involved directly in inflammatory and vascular responses in endothelial and vascular smooth muscle cells. New insights into fundamental aspects of PPAR and RXR biology, and their actions in the vasculature, continue to appear. Although RXRs are obligate heterodimeric partners for PPAR action, the part that RXRs, and their endogenous retinoid mediators, exert in the vessel wall is less well understood. Biological insights into PPAR-RXRs may help inform interpretation of clinical trials with synthetic PPAR agonists and prospects for future PPAR therapeutics. Importantly, the extensive data establishing a key role for PPARs and RXRs in energy balance, inflammation, and vascular biology stands separately from the clinical experience with any given synthetic PPAR agonist. Both the basic science data and the clinical experience with PPAR agonists identify the need to better understand these important transcriptional regulators.
Sir Thomas Browne: Selected Writings
Authors: Charles G. Roland
Journal: JAMA (1969)

William Osler once wrote that a liberal education may be had at a slight cost of time and money. His method was to delve, half an hour each night, into a few carefully selected classics from his bedside library. Modern self-educators will find this compilation by Keynes an excellent addition to<i>their</i>bedside library, and unquestionably an aid to a liberal education. Sir Thomas Browne is not an "easy" author, but the comprehension that follows careful reading is a particularly satisfying sensation, somewhat akin to working out a T. S. Eliot poem. And Browne is certainly worth the effort. No thoughtful physician can fail to be, in turn, amused, moved, and enlightened by "Religio Medici." Osler called his copy of this book the most precious in his library. Browne's style is somewhat spectacular by contemporary standards. But his writings abound in treasures: Where we desire to be informed, 'tis good
The Need for Intraoperative Parathyroid Hormone Monitoring During Radioguided Parathyroidectomy by Video-Assisted Thoracoscopy (VATS)
Authors: Jeffrey L. Wild, Tracey Weigel, Herbert Chen
Journal: Clinical Nuclear Medicine (2005)

Purpose: We report on a patient with primary hyperparathyroidism (1HPT) who had a preoperative Tc-99m sestamibi scan localizing a single parathyroid adenoma in the mediastinum. Methods: On removal of this hyperfunctioning adenoma by radioguided video-assisted thoracoscopic surgery (VATS), intraoperative PTH levels failed to decline in the appropriate manner consistent with curative resection. This prompted the surgical team to investigate further for a second adenoma, which revealed a 2 × 1-cm mass near the inferior border of the thyroid gland on the right lateral aspect of the trachea. Results: In the absence of intraoperative PTH monitoring, the operation would have been terminated after the removal of the mediastinal adenoma, leading to an incomplete surgical resection and persistent 1HPT. Conclusion: In our patient, curative resection was obtained and a second operation was avoided because of the use of intraoperative PTH monitoring. This case also emphasizes that although VATS was planned, in treating patients with 1HPT, one must also be prepared to perform a neck exploration.
Effect of administration of intestinal anthelmintic drugs on haemoglobin: systematic review of randomised controlled trials
Authors: Anjana Gulani, Jitender Nagpal, Clive Osmond, H P S Sachdev
Journal: BMJ (2007)

<b>Objective</b> To evaluate the effect of routine administration of intestinal anthelmintic drugs on haemoglobin. <b>Design</b> Systematic review of randomised controlled trials. <b>Data sources</b> Electronic databases and hand search of reviews, bibliographies of books, and abstracts and proceedings of international conferences. <b>Study selection</b> Included studies were randomised or quasi-randomised controlled trials using an intestinal anthelmintic agent in the intervention group, in which haemoglobin was evaluated as an outcome measure. Trials in which treatment for schistosoma (praziquantel) was given exclusively to the intervention group were excluded. <b>Results</b> The search identified 14 eligible randomised controlled trials. Data were available for 7829 subjects, of whom 4107 received an anthelmintic drug and 3722 received placebo. The pooled weighted mean difference (random effect model) of the change in haemoglobin was 1.71 (95% confidence interval 0.70 to 2.73) g/l (P&lt;0.001; test for heterogeneity: Cochran Q=51.17, P&lt;0.001; <i>I</i><sup>2</sup>=61% (37% to 76%)). With the World Health Organization9s recommended haemoglobin cut-offs of 120 g/l in adults and 110 g/l in children, the average estimated reduction in prevalence of anaemia ranged from 1.1% to 12.4% in adults and from 4.4% to 21.0% in children. The estimated reductions in the prevalence of anaemia increased with lower haemoglobin cut-offs used to define anaemia. <b>Conclusions</b> Routine administration of intestinal anthelmintic agents results in a marginal increase in haemoglobin (1.71 g/l), which could translate on a public health scale into a small (5% to 10%) reduction in the prevalence of anaemia in populations with a relatively high prevalence of intestinal helminthiasis.
What the Book Says
Authors: Chad D. Kollas
Journal: Annals of Internal Medicine (1997)

On Being a Patient1 August 1997What the Book SaysChad D. Kollas, MDChad D. Kollas, MDGeisinger Medical Center; Danville, PA 17822-3103Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-3-199708010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail May I please have something for pain?”“Well, I'll have to page the surgical intern on call. Nothing is ordered because you have the epidural.”“Thank you,” I called to the nurse as she left the room. The plain, institutional clock below the wall-mounted television read 8:00 p.m. My wife and I chatted idly while sitcoms played in the background. An hour passed. The pain grew worse. I pressed the nurse button on my hospital bed.“Has the surgical intern ordered anything for pain?”“Well, he checked the book and paged his senior resident. They said to give you this.”... Author, Article, and Disclosure InformationAffiliations: Geisinger Medical Center; Danville, PA 17822-3103Corresponding Author: Chad D. Kollas, MD, Department of General Internal Medicine, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822-3103. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1997Volume 127, Issue 3Page: 238-239KeywordsAnesthesiaAnestheticsBloodBlood pressureHemoglobinHypertensionHypotensionIntensive care unitsNursesSurgery Issue Published: 1 August 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Surfer's knots. Associated bone changes and medical problems
Authors: D. W. Gelfand
Journal: JAMA (1966)

SURF RIDING is largely confined to the beaches of California and Hawaii, but is now gaining in popularity on the east coast as well. The physical hazards of this very exhilarating sport are those expected from the use of a heavy fiber glass surfboard in a pounding surf. These hazards include a large assortment of cuts and bruises, and an occasional fatality produced by a rapidly moving board striking the head. In addition, regular devotees of the sport acquire surfers' knots, soft-tissue swellings on the dorsum of the foot and just below the knee.<sup>1</sup>Surfers' knots are produced at these points by kneeling for long periods of time on a floating surfboard while waiting for a wave. When the surfer kneels on the board, the feet are tucked under the buttocks with most of the body's weight brought to bear on the dorsum of the foot.<sup>2</sup> Bone changes
THE REGENERATION OF AUTOPLASTIC LYMPH NODE TRANSPLANTS
Authors: Henry L. Jaffe, Maurice N. Richter
Journal: The Journal of Experimental Medicine (1928)

The reticulum plays an important part in the regeneration of lymph nodes autoplastically transplanted into the abdominal wall of the albino rat. The necrosis which follows transplantation involves mainly the lymphocytes. A margin of lymphocytes is preserved only at the periphery. This may be due to early lymphatic connection with the marginal sinus of the node. The reticulum cells are apparently more resistant since for the most part they do not degenerate. There are three possible origins of the lymphocytes of the regenerated node. They may arise by proliferation of lymphocytes retained at the periphery of the plant. The presence of a few mitotic figures among lymphocytes in the marginal region confirms the possibility of this mode of origin. They may also be derived from lymphocytes brought into the transplant by the blood or lymph circulation. Though some lymphocytes are present in the marginal sinus, and an occasional lymphocyte is seen in the capillaries which enter at the hilus, we believe that this source of origin of the lymphocytes is negligible. On the other hand, the hyperplastic reticulum appears to be the important source of lymphocyte production. These may be derived from the reticulum directly as small lymphocytes, or may be formed through the intermediary stage of large lymphoid cells. This capacity is not limited to lymphatic reticulum, as small foci of lymphocyte formation are found in the connective tissue in the vicinity. of the transplants. The reticular origin of lymphoctes is most easily observed in the earlier stages of regeneration before the picture is obscured by the numerous small lymphocytes. Two structures in the regenerating node are directly traceable to the same structures of the transplanrt. These are the marginal sinus and the hilus. The marginal sinus of thef transplant is preserved, and is probably an important means by which lymphatic communication is established with the surrounding tissue. The hilus is the site of entry of the blood vessels, and the hilus of the regenerated node is the same as that of the transplant.
Anaphylaxis to Flucytosine in a Patient With AIDS
Authors: Shigemitsu Kotani
Journal: JAMA (1988)

<h3>To the Editor. —</h3> Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk of hypersensitivity reactions to trimethoprim-sulfamethoxazole.<sup>1-4</sup>The reason for this is not clear but may be explained by the abnormal immunoregulation in hosts infected with human immunodeficiency virus—1. We report herein a patient with AIDS who manifested anaphylactoid reactions on two occasions after ingestion of flucytosine. <h3>Report of a Case. —</h3> A 25-year-old man had been diagnosed as having hemophilia A at the age of 21 years. He had been infused with factor VIII concentrate in 1982 and in 1984 when he sustained traumatic injuries. Symptoms of AIDS began to appear in January 1986, with fever, exertional dyspnea, and diarrhea. On admission he was found to have oral candidiasis and right-sided retroauricular abscess that yielded<i>Nocardia</i>on culture. His chest roentgenograms showed a ground-glass appearance. Results of laboratory examination disclosed a lymphocyte count of 0.81 ×
Metformin: A Diabetes Drug for Cancer, or a Cancer Drug for Diabetics?
Authors: Matthew Martin, Richard Marais
Journal: Journal of Clinical Oncology (2012)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2012.42.1677 Journal of Clinical Oncology - published online before print May 7, 2012 PMID: 22565000 Metformin: A Diabetes Drug for Cancer, or a Cancer Drug for Diabetics? Matthew MartinxMatthew MartinSearch for articles by this author Richard MaraisxRichard MaraisSearch for articles by this author Show More The Institute of Cancer Research, London, United KingdomThe Paterson Institute for Cancer Research, Manchester, United Kingdom https://doi.org/10.1200/JCO.2012.42.1677 First Page Full Text PDF Figures and Tables © 2012 by American Society of Clinical Oncology
RAC Approves Policy for Single-Patient Use of Gene Therapy
Authors: S. Jenks
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article RAC Approves Policy for Single-Patient Use of Gene Therapy Get access Susan Jenks Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 4, 17 February 1993, Pages 266–267, https://doi.org/10.1093/jnci/85.4.266 Published: 17 February 1993
Epicardial Activation of Left Ventricular Wall Prolongs QT Interval and Transmural Dispersion of Repolarization
Authors: Jeffrey M. Fish, José M. Di Diego, Vladislav Nesterenko, Charles Antzelevitch
Journal: Circulation (2004)

Background— Epicardial pacing of the left ventricle (LV) has been shown to prolong the QT interval and predispose to the development of torsade de pointes arrhythmias. The present study examines the cellular basis for QT prolongation and arrhythmogenesis after reversal of the direction of activation of the LV wall. Methods and Results— A transmural ECG and transmembrane action potentials were simultaneously recorded from epicardial, M, and endocardial cells of arterially perfused canine LV wedge preparations. QT interval increased from 297.6±3.9 to 314.0±5.7 ms (n=12; P &lt;0.001) and transmural dispersion of repolarization (TDR) increased from 35.5±5.2 to 70.3±6.2 ms (n=12; P &lt;0.001) as pacing was shifted from endocardium to epicardium. Conduction time between M and epicardial cells increased from 12.1±1.2 to 24.2±1.5 ms (n=12; P &lt;0.001). Amplification of TDR was further accentuated in the presence of rapidly activating delayed rectifier potassium current blockers (E-4031 and cisapride), increasing from 50.5±7.6 to 86.1±6.2 ms (n=8; P &lt;0.01). Torsade de pointes arrhythmias could be induced during epicardial, but not endocardial, pacing of LV in the presence of rapidly activating delayed rectifier potassium current blockade. Conclusions— Reversal of the direction of activation of the LV wall, as occurs during biventricular pacing, leads to a prominent increase in QT and TDR as a result of earlier repolarization of epicardium and delayed activation and repolarization of the midmyocardial M cells. The increase in TDR creates the substrate for the development of torsade de pointes under long-QT conditions.
Mouse Model for Lowe Syndrome/Dent Disease 2 Renal Tubulopathy
Authors: Susan P. Bothwell, Emily Chan, Isa M. Bernardini, Yien-Ming Kuo, William A. Gahl, Robert L. Nussbaum
Journal: Journal of the American Society of Nephrology (2010)

The Lowe oculocerebrorenal syndrome is an X-linked disorder characterized by congenital cataracts, cognitive disability, and proximal tubular dysfunction. Both this syndrome and Dent Disease 2 result from loss-of-function mutations in the OCRL gene, which encodes a type II phosphatidylinositol bisphosphate 5-phosphatase. Ocrl-deficient mice are unaffected, however, which we believe reflects a difference in how humans and mice cope with the enzyme deficiency. Inpp5b and INPP5B, paralogous autosomal genes that encode another type II phosphoinositide 5-phosphatase in mice and humans, respectively, might explain the distinct phenotype in the two species because they are the closest paralogs to Ocrl and OCRL in their respective genomes yet differ between the two species with regard to expression and splicing. Here, we generated Ocrl(-/-) mice that express INPP5B but not Inpp5b. Similar to the human syndromes, all showed reduced postnatal growth, low molecular weight proteinuria, and aminoaciduria. Thus, we created an animal model for OCRL and Dent Disease 2 tubulopathy by humanizing a modifier paralog in mice already carrying the mutant disease gene.
Safety of Early Discharge for Medicaid Newborns
Authors: Uma R. Kotagal
Journal: JAMA (1999)

ContextNeonates are being discharged from the hospital more rapidly, but the risks associated with this practice, especially for low-income populations, are unclear.ObjectiveTo determine the impact of decreasing postnatal length of stay on rehospitalization rates in the immediate postdischarge period for Medicaid neonates.Design and SettingRetrospective, population-based cohort study using Ohio Medicaid claims data linked to vital statistics files from July 1, 1991, to June 15, 1995.ParticipantsA total of 102,678 full-term neonates born to mothers receiving Medicaid for at least 30 days after birth.Main Outcome MeasuresRehospitalization rates within 7 and 14 days of discharge, postdischarge health care use, and regional variations in length of stay and rehospitalization.ResultsThe proportion of neonates who were discharged following a short stay (less than 1 day after vaginal delivery, less than 2 days after cesarean birth) increased 185%, from 21% to 59.8% (P<.001) and the mean (SD) length of stay decreased 27%, from 2.2 (1.0) to 1.6 (0.9) days (P<.001), over the course of the study. The proportion of neonates who received a primary care visit within 14 days of birth increased 117% (P=.001). Rehospitalization rates within 7 and 14 days of discharge decreased by 23%, from 1.3% to 1.0% (P=.01), and by 19%, from 2.1% to 1.7% (P=.03), respectively. Short stay across the 6 regions of the state varied significantly over time (P<.001). Factors significantly associated with increased likelihood of rehospitalization within both 7 and 14 days of discharge were white race, shorter gestation, primiparity, earlier year of birth, lower 5-minute Apgar score, vaginal delivery, married mother, and region of the state.ConclusionOur data suggest that reductions in length of stay for full-term Medicaid newborns in Ohio have not resulted in an increase in rehospitalization rates in the immediate postnatal period.