tbuckley/cabot-search huggingface dataset:
The world's first international tobacco control treaty
Authors: A. B Gilmore
Journal: BMJ (2002)

heterogeneous nature of the condition and because most data derive from case reports or case series from single centres-large case control studies and randomised controlled trials are scant.The International Collaboration on Endocarditis has been conceived recently to develop a large global database of patients whose clinical, echocardiographic, and microbiological findings have been characterised by using standard methodology.The associated network of investigators and organisational infrastructure will provide the platform for large randomised trials to test therapeutic strategies. 12This resource offers the opportunity for major advances in our understanding and treatment of infective endocarditis over the next two decades and provides a model on which global collaboration in other disease areas is likely to be based.
Cutaneous Anthrax treated with Penicillin
Authors: A. M. Abrahams
Journal: BMJ (1945)

March 28.The C.S.F. was then clear and the cell count 3 lymphocytes per c.mm.; protein, 20 mg. per 100 c.cm.Apart from the usual nursing measures, the only treatment was a course of sulphadiazine starting on March 24 and finishing on March 27, a total of 21 g.being given. CommentaryIn this case an almost latent parotitis was followed three days later by a fairly severe orchitis, 36 hours after which meningo-encephalitis manifested itself.The unusual features were the low C.S.F.cell count, the rather high sugar, and the presence of papilloedema.The mental confusion, drowsiness, twitching of the facial muscles, and the C.S.F.findings indi- cated an encephalitis.The clinical evidence of cerebral and meningeal involvement would suggest much more extensive changes in the C.S.F.than were actually found.The cell count was only slightly raised and the protein was normal.In the case described by Coe (1945) the cell count varied from 90 to 100 per c.mm. Harris and Bethell (1938) found 740 cells per c.mm. in the C.S.F. of the case they reported.Synge (1930) describes a case with a C.S.F.cell count of 300 per c.mm.In the five cases reported by Frankland (1941) the C.S.F.cell -count varied from 230 to 1,078 per c.mm.None of these authors noted papilloedema in their cases, nor was it mentioned by Rolleston (1932).Price (1942), however, states that papill- oedema and even optic atrophy occur as a sequel.The high initial pyrexia and relative bradycardia found in our case conform to previous case reports in the literature.The parotitis was very mild, and its presence was revealed only by a further close questioning of the patient when it appeared to us that mumps alone could explain the presence of a coinci- dent meningo-encephalitis and orchitis.There was no history of any contact with another case of mumps.There was a high initial polymorphonucleosis, but as the orchitis subsided an absolute lymphocytosis developed, as is usual in mumps.Recovery was complete and rapid.We do not consider that it was influenced-to any extent by the use of sulphadiazine.Summary A case of mumps with a mild parotitis and a fairly severe orchitis and meningo-encephalitis is described.The case is unusual in that the C.S.F.cell count was only slightly raised and, apart from slight increase in sugar, the C.S.F. was otherwise chemically normal.Papilloedema was a feature of the case, but was not followed by any impairment of vision.
Scottish study will look at genetic and lifestyle causes of ill health in families
Authors: Bryan Christie
Journal: BMJ (2006)

One of the United Kingdom's largest family health studies has begun in Scotland. It will explore the causes of common diseases by tracking 50 000 people over the next 20 years.

The project, known as Generation Scotland, is a collaboration between the country's five medical schools, a number of biomedical research institutes, and the Scottish national health service. …
A Malawian child meets an English surgeon
Authors: R. Brueton
Journal: BMJ (2009)

I came across him by chance in a village in Malawi. His father had spent the three years of his son’s life trying to find a surgeon to operate on his club foot. He had been to Lilongwe, the capital, and to his local town, but to no avail. With only one Malawian orthopaedic surgeon and four expatriate orthopods, of whom I was one, serving the country’s population of 12 million, his chances were low.

That morning we had driven four hours from Blantyre on a good road to do an orthopaedic outpatient clinic in the hospital in his town, only to find that all the patients were waiting in a nearby village. In my naivety I decided to go on to this village, which apparently was only a one hour journey off road. It was at the end of the rainy season, and as we slipped off the muddy track into a ditch for a second time it dawned on me that they had not made it to the town because they could not travel. The sound of a four wheel drive in distress was music to the ears of the local children, who appeared from nowhere, …
<i>Strongyloides stercoralis</i>Hyperinfection
Authors: Stephen R Gorman, Donald E Craven
Journal: New England Journal of Medicine (2008)

A 46-year-old man from Cambodia presented with myalgias and an elevated creatine kinase. After 4 weeks of empirical therapy with oral corticosteroids, pulmonary hemorrhage, hypoxemic respiratory failure, and septic shock occurred.
Botulism in the United States: A Clinical and Epidemiologic Review
Authors: Roger L. Shapiro
Journal: Annals of Internal Medicine (1998)

Botulism is caused by a neurotoxin produced from the anaerobic, spore-forming bacterium Clostridium botulinum. Botulism in humans is usually caused by toxin types A, B, and E. Since 1973, a median of 24 cases of foodborne botulism, 3 cases of wound botulism, and 71 cases of infant botulism have been reported annually to the Centers for Disease Control and Prevention (CDC). New vehicles for transmission have emerged in recent decades, and wound botulism associated with black tar heroin has increased dramatically since 1994. Recently, the potential terrorist use of botulinum toxin has become an important concern. Botulism is characterized by symmetric, descending, flaccid paralysis of motor and autonomic nerves, usually beginning with the cranial nerves.Blurred vision, dysphagia, and dysarthria are common initial complaints. The diagnosis of botulism is based on compatible clinical findings; history of exposure to suspect foods; and supportive ancillary testing to rule out other causes of neurologic dysfunction that mimic botulism, such as stroke, the Guillain-Barre syndrome, and myasthenia gravis. Laboratory confirmation of suspected cases is performed at the CDC and some state laboratories. Treatment includes supportive care and trivalent equine antitoxin, which reduces mortality if administered early. The CDC releases botulism antitoxin through an emergency distribution system. Although rare, botulism outbreaks are a public health emergency that require rapid recognition to prevent additional cases and to effectively treat patients. Because clinicians are the first to treat patients in any type of botulism outbreak, they must know how to recognize, diagnose, and treat this rare but potentially lethal disease.
SKIN TESTS IN ATOPIC DISEASE
Authors: David Louis Engelsher
Journal: JAMA (1953)

To the Editor:  —The article Skin Tests in Atopic Disease inThe Journal, March 7, 1953, page 785, was very interesting; however, it contained statements that I believe require modification in three ways.  First, the routine allergy list in table 1 omits a very important allergen, horse serum. It is essential to know if a patient is sensitive to this substance, because of the possibility of giving it by injection via antitoxin. The knowledge that he reacts positively may prevent much future trouble. When the reaction is positive, I check on whether the patient has been immunized for tetanus and diphtheria, advising toxoid immunization if this has not been done. A certificate is given to the patient, if he is sensitive to horse serum, stating this condition, and, if he has been actively immunized, advising a booster injection, should the possibility of tetanus arise. If in addition to the booster
David John Woolford
Authors: Marcus Woolford
Journal: BMJ (2006)

​FormerFormer general practitioner Oakham, Rutland (b 1924; q The London Hospital 1949; MA, DObst RCOG), died from complications of myelodysplasia on 3 July 2005.



Figure 1



David served as a captain in the Royal Army Medical Corps and was stationed in Malaya, where he took part in the “Emergency of 1952” as a family medical officer, caring for the wives of Ghurkhas in the jungle. Later he was posted to a services mission in Burma, where he looked after the families of embassy staff. As well as being a general practitioner, he was medical and anaesthetics officer at Rutland Memorial Hospital and medical officer at Ashwell Prison. He also gave anaesthetics for the school dental officer for Rutland. He retired in 1991. He leaves a wife, Halina; three sons; and four grandchildren.
The treatment effect of alpha interferon in chronic hepatitis B is independent of pre-treatment variables. Results based on individual patient data from 10 clinical controlled trials
Authors: Kim Krogsgaard, Niels Bindslev, Erik Christensen, Antonio Craxi, Poul Schlichting, Solko Schalm, Vicente Carreno, Christian Trepo, Guido Gerken, Howard C. Thomas, Per Kragh Andersen, Helmer Ring-Larsen
Journal: Journal of Hepatology (1994)
GermOnline, a new cross-species community annotation database on germ-line development and gametogenesis
Authors: M Primig, C Wiederkehr, R Basavaraj, C Sarrauste de Menthière, L Hermida, R Koch, U Schlecht, H G Dickinson, M Fellous, J A Grootegoed, R S Hawley, B Jégou, B Maro, A Nicolas, T Orr-Weaver, T Schedl, A Villeneuve, D J Wolgemuth, M Yamamoto, D Zickler, N Lamb, R E Esposito
Journal: Nature Genetics (2003)
Payment of clinical research subjects
Authors: C. Grady
Journal: Journal of Clinical Investigation (2005)

Offering payment to clinical research subjects, in an effort to enhance recruitment by providing an incentive to take part or enabling subjects to participate without financial sacrifice, is a common yet uneven and contentious practice in the US. Concern exists regarding the potential for payment to unduly influence participation and thus obscure risks, impair judgment, or encourage misrepresentation. Heightening these concerns is the participation not only of adults but also of children in pediatric research trials. Thorough assessment of risks, careful eligibility screening, and attention to a participant's freedom to refuse all serve to reduce the possibility of compensation adversely affecting the individual and/or the study. Institutional review boards currently evaluate payment proposals with minimal guidance from federal regulations. Here, reasons for providing payment, payment models, ethical concerns, and areas for further research are examined.
Medical application of microencapsulating hybridoma cells in agarose microbeads `cytomedicine': therapeutic effect on IgG1 plasmacytosis and mesangio-proliferative glomerulonephritis in the interleukin 6 transgenic mouse
Authors: Naoki Okada, Hajime Miyamoto, Yoshihisa Kaneda, Yoko Yamamoto, Asao Katsume, Hiroyuki Saito, Keigo Yorozu, Otoya Ueda, Yasuo Tsutsumi, Shinsaku Nakagawa
Journal: Journal of Controlled Release (1997)
Points: Medicine and politics
Authors: M A R Freeman
Journal: BMJ (1987)

Dr Norman D Noah (16 May, p 1270) rightly draws attention to the comparatively limited information available on compulsory childhood immunisation and its impact in eastern European countries.He specifically mentions Czechoslovakia, a country which I recently visited as a medical geographer with a specific interest in vaccination uptake and the epidemiology of infectious disease.In Czechoslovakia virtual eradication ofmeasles seems to have been attained by a combination of compulsory childhood immunisation and the measures which Dr Noah commends: administrative methods, health education, and service delivery.Though immunisa-
Prevention of Acquired Immunodeficiency Syndrome
Authors: ARTHUR E. PITCHENICK
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 April 1983Prevention of Acquired Immunodeficiency SyndromeARTHUR E. PITCHENICK, M.D., MARGARET A. FISCHL, M.D.ARTHUR E. PITCHENICK, M.D.Search for more papers by this author, MARGARET A. FISCHL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-4-558_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the February 1982 issue, Reiner and associates (1) presented evidence for parenteral transmission of hepatitis B virus via sexual contact among homosexual men. They also referred to an unpublished study in which oral-anal and genital-anal intercourse among homosexual men correlated most strongly with serologic evidence of hepatitis B virus infection. The epidemiologic findings of acquired immunodeficiency syndrome are suggestive of a new infectious agent (perhaps a virus) that is transmissible via the blood and also sexually, similar to hepatitis B. In fact, a high percent of patients with the syndrome have antibody evidence of past infection...References1. REINERJUDSONBONDFRANCISPETERSEN NFWDN. Asymptomatic rectal mucosal lesions and hepatitis B surface antigen at sites of sexual contact in homosexual men with persistent hepatitis B virus infection: evidence for de facto parenteral transmission. Ann Intern Med. 1982;96:170-3. LinkGoogle Scholar2. FREIDMAN-KIENLAUBENSTEINRUBENSTEIN LP. Disseminated Kaposi's sarcoma in homosexual men. Ann Intern Med. 1982;96:693-700. LinkGoogle Scholar3. PITCHENIKFISCHLDICKINSON AMG. Opportunistic infections and Kaposi's sarcoma among Haitians: evidence of a new acquired immunodeficiency state. Ann Intern Med. 1983;98:277-84. LinkGoogle Scholar4. COREY L. Genital herpes: an overview and update. Helper. 1982;4(1):1-2. Google Scholar5. BARLOW D. The condom and gonorrhea. Lancet. 1977;2:811-2. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Miami School of Medicine Miami, FL 33101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTuberculosis And Nontuberculous Mycobacterial DiseaseCharacterization of Specific Immune Complexes in HIV-Related DisordersSafe sex in prophylaxis of AIDS 1 April 1983Volume 98, Issue 4Page: 558-559KeywordsAIDSBloodEpidemiologyHepatitis AHepatitis BHepatitis B virusHomosexuals Issue Published: 1 April 1983 PDF DownloadLoading ...
Interleukin-4 Production by Follicular Helper T Cells Requires the Conserved Il4 Enhancer Hypersensitivity Site V
Authors: Pandurangan Vijayanand, Grégory Seumois, Laura J. Simpson, Sarah Abdul-Wajid, Dirk Baumjohann, Marisella Panduro, Xiaozhu Huang, Jeneen Interlandi, Ivana M. Djuretic, Daniel R. Brown, Arlene H. Sharpe, Anjana Rao, K. Mark Ansel
Journal: Immunity (2012)
The Good Doctor
Authors: Shekinah Elmore
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The DamX protein of<i>Escherichia coli</i>and<i>Salmonella enterica</i>
Authors: Javier López-Garrido, Josep Casadesús
Journal: Gut Microbes (2010)

We recently showed that disruption of damX causes bile sensitivity in Salmonella enterica. The damX gene is part of an operon that contains genes with heterogeneous functions: DNA adenine methylation, biosynthesis of aromatic compounds, carbohydrate metabolism, and tRNA charging. The damX gene encodes a protein with a predicted size of 46 kDa. In Salmonella, DamX is found in the inner membrane of both dividing and non-dividing cells. The DamX protein contains a peptidoglycan-binding SPOR domain, and accumulates in the E. coli septal ring. E. coli mutants lacking DamX are bile-sensitive like their Salmonella counterparts.
Altered Proliferative Response by T Lymphocytes of Ly-6A (Sca-1) Null Mice
Authors: William L. Stanford, Salma Haque, Robert Alexander, Xuemei Liu, Anne M. Latour, H. Ralph Snodgrass, Beverly H. Koller, Patrick M. Flood
Journal: The Journal of Experimental Medicine (1997)

Ly-6A is a murine antigen which is implicated in lymphocyte activation and may be involved in activation of hematopoietic stem cells. Antibody cross-linking studies and antisense experiments have suggested that Ly-6A is a lymphocyte coactivation molecule. To better understand the function of Ly-6A, we used gene targeting to produce Ly-6A null mice which are healthy and have normal numbers and percentages of hematopoietic lineages. However, T lymphocytes from Ly-6A–deficient animals proliferate at a significantly higher rate in response to antigens and mitogens than wild-type littermates. In addition, Ly-6A mutant splenocytes generate more cytotoxic T lymphocytes compared to wild-type splenocytes when cocultured with alloantigen. This enhanced proliferation is not due to alterations in kinetics of response, sensitivity to stimulant concentration, or cytokine production by the T cell population, and is manifest in both in vivo and in vitro T cell responses. Moreover, T cells from Ly-6A–deficient animals exhibit a prolonged proliferative response to antigen stimulation, thereby suggesting that Ly-6A acts to downmodulate lymphocyte responses.
Posttranscriptional Silencing of Effector Cytokine mRNA Underlies the Anergic Phenotype of Self-Reactive T Cells
Authors: Alejandro V. Villarino, Shoshana D. Katzman, Eugenio Gallo, Omer Miller, Shuwei Jiang, Michael T. McManus, Abul K. Abbas
Journal: Immunity (2011)
Primary localized cutaneous amyloidosis: dermal amyloid deposits do not bind antibodies to amyloid A protein, prealbumin or fibronectin
Authors: S.M. BREATHNACH, B. BHOGAL, F.C. BEER, M.M. BLACK, M.B. PEPYS
Journal: British Journal of Dermatology (1982)

Journal Article Primary localized cutaneous amyloidosis: dermal amyloid deposits do not bind antibodies to amyloid A protein, prealbumin or fibronectin Get access S.M. BREATHNACH, S.M. BREATHNACH Institute of Dermatology, St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar B. BHOGAL, B. BHOGAL Institute of Dermatology, St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar F.C. DE BEER, F.C. DE BEER Immunological Medicine Unit, Department of Medicine, Royal Postgraduate Medical School, Du Cane Road, London W12 0HS Search for other works by this author on: Oxford Academic Google Scholar M.M. BLACK, M.M. BLACK Institute of Dermatology, St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar M.B. PEPYS M.B. PEPYS Immunological Medicine Unit, Department of Medicine, Royal Postgraduate Medical School, Du Cane Road, London W12 0HS Dr M.B.Pepys, Immunological Medicine Unit, Department of Medicine, Royal Postgraduate, Medical School, Du Cane Road, London W12 OHS. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 4, 1 October 1982, Pages 453–459, https://doi.org/10.1111/j.1365-2133.1982.tb00388.x Published: 01 October 1982 Article history Accepted: 05 April 1982 Published: 01 October 1982
1287 UNREVEALING A NOVEL ASSOCIATION OF CHOLESTEROL ESTER STORAGE DISEASE (CESD) &amp; NON ALCOHOLIC FATTY LIVER DISEASE(NAFLD)-A SIMILAR CLINICAL SPECTRUM WITH DIFFERENT ETIOLOGY A PROSPECTIVE CLINICAL STUDY
Authors: P.P. Basu, T. Nair, S. Farhat, S. Foustin, L. Ang, A. Anwarullah, M. Jafri, N. James Shah
Journal: Journal of Hepatology (2012)
Effect of prostaglandins on the adult rat stomach and intestine.
Authors: F Halter, A Baumgartner, H R Koelz, W H Reinhart
Journal: Gut (1987)

BACKGROUND--This study was designed to investigate the contribution of inhaled salbutamol to the increase in resting metabolic rate found in patients with chronic airflow limitation who were receiving bronchodilator therapy. METHODS--The resting metabolic rate of 10 normal subjects (age 20-47 years, weight 42-105 kg, seven men) was studied after inhalations of salbutamol or placebo. An open canopy method of indirect calorimetry was used to measure resting oxygen consumption (VO2) and resting carbon dioxide production (VCO2). Subjects inhaled two, four, eight, or 12 puffs (100 micrograms/puff) of salbutamol or placebo in a double blind manner. Recordings of VO2 and VCO2 were made after inhalation of the four doses of salbutamol or placebo, integrated over one hour, and compared. RESULTS--VO2 and VCO2 increased in a dose dependent manner after inhaled salbutamol with a maximum effect at five minutes after inhalation. After four puffs, VO2 was 203 and 188 ml/kg/h for salbutamol and placebo respectively. After eight puffs, VO2 was 207 and 185 and VCO2 was 167 and 155 ml/kg/h. After 12 puffs, VO2 was 220 and 190 with a VCO2 of 181 and 168 ml/kg/h. Twelve puffs of salbutamol increased the mean (SE) respiratory quotient from 0.85 (0.01) to 0.93 (0.04) at five minutes indicating an increase in ventilation in excess of metabolic demand. Mean heart rate increased in parallel with VO2. CONCLUSION--Inhaled salbutamol significantly increases resting metabolic rate in a dose dependent manner.
569 HUMAN-SCALE TRANSPLANTABLE LIVER GRAFT USING DECELLULARIZED WHOLE-ORGAN SCAFFOLD
Authors: H. Yagi, A. Soto-Gutierrrez, T. Hibi, Y. Abe, K. Tanaka, M. Kitago, H. Obara, O. Itano, M. Tanabe, Y. Kitagawa
Journal: Journal of Hepatology (2013)
Bioluminescence imaging of calvarial bone repair using bone marrow and adipose tissue-derived mesenchymal stem cells
Authors: Irene R. Dégano, Marta Vilalta, Juli R. Bagó, Annette M. Matthies, Jeffrey A. Hubbell, Helen Dimitriou, Paolo Bianco, Nuria Rubio, Jerónimo Blanco
Journal: Biomaterials (2007)