tbuckley/cabot-search huggingface dataset:
Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population
Authors: Ruth Frikke-Schmidt, Børge G. Nordestgaard, Gorm B. Jensen, Anne Tybjærg-Hansen
Journal: Journal of Clinical Investigation (2004)

Homozygosity for mutations in ABC transporter A1 (ABCA1) causes Tangier disease, a rare HDL-deficiency syndrome. Whether heterozygosity for genetic variation in ABCA1 also contributes to HDL cholesterol (HDL-C) levels in the general population is presently unclear. We determined whether mutations or single-nucleotide polymorphisms (SNPs) in ABCA1 were overrepresented in individuals with the lowest 1% (n=95) or highest 1% (n=95) HDL-C levels in the general population by screening the core promoter and coding region of ABCA1. For all nonsynonymous SNPs identified, we determined the effect of genotype on lipid traits in 9,259 individuals from the general population. Heterozygosity for ABCA1 mutations was identified in 10% of individuals with low HDL-C only. Three of 6 nonsynonymous SNPs (V771M, V825I, and R1587K) were associated with increases or decreases in HDL-C in women in the general population and some with consistent trends in men, determined as isolated single-site effects varying only at the relevant SNP. Finally, these results were consistent over time. In conclusion, we show that at least 10% of individuals with low HDL-C in the general population are heterozygous for mutations in ABCA1 and that both mutations and SNPs in ABCA1 contribute to HDL-C levels in the general population.
Failure of the Defensive Functions of the Ego in Dreams of Psychosomatic Patients
Authors: Harold L. Levitan
Journal: Psychotherapy and Psychosomatics (1981)

Four types of recurrent dreams regularly encountered in psychosomatic patients are presented. Three of the types of dreams demonstrate a total failure of the defensive functions of the ego. A fourth type demonstrates a nearly total failure. The implications for production of illness of this failure of defense in dreams are discussed.
Granulomatous Ulcer of the Nose Treated with Chloramphenicol
Authors: I. B. Sneddon, J. Colquhoun
Journal: BMJ (1952)

ACUTE BERIBERI COMPLICATING POLYSEROSmS BrBJOUsIn addition to the deficiency of vitamin B1 the temporary presence of hyperkeratosis and of some darkening of the skin suggest some deficiency of vitamin A and of nico- tinic acid.Both signs regressed completely after cure of the vitamin-B, deficiency and the taking of a normal diet.There were never any signs of riboflavin deficiency.ADDENDUM.-During 1951it became obvious that con- strictive pericarditis had developed.In consultation with Professor 1. G. W. Hill and Mr. M. Fallon it was decided to carry out pericardectomy, which was done on June 5, 1951.The patient made an uneventful recovery, and is now (January, 1952) attending school once more.Vitamin supplements were continued until the time of operation.Tuberculous tissue was found in the parietal pericardium removed at operation. SummaryA case of multiple vitamin deficiency presenting the clinical picture of acute beriberi is reported in a patient suffering from polyserositis, possibly of tuberculous origin.It is suggested that the toxic, process causing the polyserositis also produced the beriberi symptoms.No similar case has been discovered in the British literature.
The Rise and Fall of Primary Hyperparathyroidism: A Population-Based Study in Rochester, Minnesota, 1965-1992
Authors: Robert A. Wermers
Journal: Annals of Internal Medicine (1997)

Background: The introduction of routine measurement of serum calcium levels led to a sharp increase in the incidence of primary hyperparathyroidism in the early 1970s. Objective: To evaluate the trends in the incidence of primary hyperparathyroidism since the mid-1970s. Setting: Rochester and Olmsted County, Minnesota. Design: Population-based descriptive study. Patients: All residents of Rochester, Minnesota, who received an initial diagnosis of primary hyperparathyroidism between 1965 and 1992 were identified through the medical records linkage system of the Rochester Epidemiology Project. Included as persons having definite cases (92% of the total) were patients with pathologically confirmed hyperparathyroidism, hypercalcemia with inappropriately elevated parathyroid hormone levels, or hypercalcemia that had lasted for more than a year and had no cause other than primary hyperparathyroidism. Measurements: Incidence rates were calculated and directly standardized to the population structure of white persons in the United States in 1990. Results: From 1965 to June 1974 (the prescreening era), the age- and sex-adjusted incidence of primary hyperparathyroidism in Rochester was 15 cases per 100 000 person-years. After measurement of calcium levels was added to the automated serum chemistry panel in July 1974, the incidence increased to 112 per 100 000 person-years in 1975 and then decreased somewhat, reflecting a sweeping effect. Despite improved case ascertainment, however, the incidence rate has continued to decrease; in 1992, the incidence was 4 per 100 000 person-years. A few patients had complications that might have been caused by hyperparathyroidism (22% between 1965 and June 1974 and 6% thereafter), and survival was not impaired in either period. The maximum serum calcium levels did not change (P = 0.15). Conclusions: The progressive decrease in the incidence of primary hyperparathyroidism is unexpected and suggests a significant change in the epidemiology of this disease.
Burn hazard with cement.
Authors: N R Greening, J R Tonry
Journal: BMJ (1978)

associated-as is now becoming apparent.Indeed, the situation with regard to both B27 and B5 associations may vary in different parts of the world.In our patients with Behqet's triad, two out of four are B5 positive and one out of four is B27 positive.Of those with "definite" Behqet's disease (by the criteria of Mason and Barnes5), two out of 11 are B5 positive and only one out of 11 is B27 positive.The connection with the B5 antigen seems less strong than in Turkey but further work is necessary to clarify the position.The criteria of Mason and Barnes are valuable in indicating some measure of diagnostic certainty.Patients with the triad of symptoms undoubtedly have Behqet's syn- drome.But some patients satisfy their criteria at the "definite" level without the concurrence of mouth and genital ulceration which I would now regard as obligatory.Nor would I attach much importance to the presence or absence of a family history.Thus the stated prevalence rate of 0 064 per 10 000 can be only an estimate of the disorder's prevalence: it may be a slight overestimate.In any event it contrasts markedly with the Japanese finding of 1 in 10 000.
Outcome of planned home and planned hospital births in low risk pregnancies: prospective study in midwifery practices in the Netherlands
Authors: T A Wiegers, M J N C Keirse, J van der Zee, G A H Berghs
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To investigate the relation between the intended place of birth (home or hospital) and perinatal outcome in women with low risk pregnancies after controlling for parity and social, medical, and obstetric background. <b>Design</b>: Analysis of prospective data from midwives and their clients. <b>Setting</b>: 54 midwifery practices in the province of Gelderland, Netherlands. <b>Subjects</b>: 97 midwives and 1836 women with low risk pregnancies who had planned to give birth at home or in hospital. <b>Main outcome measure</b>: Perinatal outcome index based on "maximal result with minimal intervention" and incorporating 22 items on childbirth, 9 on the condition of the newborn, and 5 on the mother after the birth. <b>Results</b>: There was no relation between the planned place of birth and perinatal outcome in primiparous women when controlling for a favourable or less favourable background. In multiparous women, perinatal outcome was significantly better for planned home births than for planned hospital births, with or without control for background variables. <b>Conclusions</b>: The outcome of planned home births is at least as good as that of planned hospital births in women at low risk receiving midwifery care in the Netherlands.
817 IDENTIFICATION OF PROGRAMMED DEATH 1 (PD-1) AND ITS COGNATE LIGANDS (PD-L1, PD-L2) IN THE PEKIN DUCK AND EXPRESSION ANALYSIS IN THE DUCK HEPATITIS B MODEL
Authors: Q. Yao, K.P. Fischer, L. Tyrrell, K.S. Gutfreund
Journal: Journal of Hepatology (2012)
Dietary intake of calcium and postmenopausal bone loss.
Authors: J. C. Stevenson, M. I. Whitehead, M. Padwick, J. A. Endacott, C. Sutton, L. M. Banks, C. Freemantle, T. J. Spinks, R. Hesp
Journal: BMJ (1988)

The use of calcium supplements to prevent postmenopausal bone loss and hence osteoporosis is widespread, but the evidence for their efficacy, either alone or in combination with other treatments, is contradictory. Skeletal measurements and dietary intake of calcium were determined in 59 healthy postmenopausal women, most of whom were within five years of the menopause. No correlation was found between current intake of calcium and either total calcium in the body or the density of trabecular or cortical bone in the forearm or vertebral trabecular bone. Dietary intake of calcium did not influence the rate of postmenopausal bone loss in the 54 women who completed 12 months of active or placebo treatment. Even when extremes of calcium intake were examined no difference was found in bone measurements between the women with the highest and lowest intakes. The results of this study suggest that the bone density of women in the early menopause is not influenced by current dietary intake of calcium.
Abstract 5470: Safe and targeted anticancer therapeutic efficacy of a novel antioxidant-conjugated difluoro-diarylidenyl-piperidone (HO-3867) against ovarian cancer
Authors: Periannan Kuppusamy, K. Selvendiran, L. Tong, A. Bratasz, ML. Kuppusamy, NJ. Trigg, BK. Rivera, T. Kálai, K. Hideg
Journal: Cancer Research (2010)

Abstract The anticancer efficacy of a novel difluorodiarylidenyl piperidone (H-4073) and its N-hydroxypyrroline modification (HO-3867) against ovarian cancer is reported. Studies were performed using established human ovarian cancer cell lines (A2870, A2780cDDP, OV-4, SKOV3, PA-1 and OVCAR3, as well as in a murine xenograft tumor (A2780) model. Both compounds were comparably and significantly cytotoxic to A2780 cells. However, HO-3867 demonstrated a preferential toxicity towards ovarian cancer cells, while sparing healthy cells. HO-3867 induced G2/M cell-cycle arrest in A2780 cells by modulating cell-cycle regulatory molecules p53, p21, p27, cdk2 and cyclin, and promoted apoptosis by caspase-8 and caspase-3 activation. It also caused an increase in the expression of functional Fas/CD95 and decreases in STAT3 (Tyr705) and JAK1 phosphorylation. There was a significant reduction in STAT3 downstream target protein levels including Bcl-xL, Bcl-2, survivin, and vascular endothelial growth factor (VEGF), suggesting that HO-3867 exposure disrupted the JAK/STAT3 signaling pathway. In addition, HO-3867 significantly inhibited the growth of the ovarian tumors in a dosage-dependent manner without any apparent toxicity. We further analyzed of xenografted tumor tissues showed that HO-3867 inhibits pSTAT3 (Tyr705 and Ser727) and Jak1 and increased apoptotic markers of cleaved caspase-3 and PARP. The results clearly showed that HO-3867 exhibited significant cytotoxicity towards ovarian cancer cells by inhibiting the JAK/STAT3-signaling pathway. The study suggested that HO-3867 may be useful as a safe and effective anticancer agent for ovarian cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5470.
Abstract 2954: Novel interaction between FLIP/DAPK: role for RON in androgen-independent prostate cancer.
Authors: Izhar S. Batth, Jingjing Gong, A. Pratap Kumar
Journal: Cancer Research (2013)

Abstract Patients with Hormone refractory metastatic prostate cancer (HRPCA) have a 5-year survival of less than 30%. Therefore, it is imperative that new therapeutic strategies targeting advanced stage prostate cancer (PCA) be developed. 2-Methoxyestradio (2-ME2) is an endogenously produced compound that has been shown to successfully treat PCA. As part of our efforts in understanding its mechanism of action, we discovered that the tyrosine kinase RON (Recepteur ‘Origine Nantais) was a target for inhibition. RON Kinase has been previously shown to be upregulated in murine PCA. RON has also been reported to mediate cell migration, and invasion in various cancers. However, the precise role of RON signaling in prostate carcinogenesis is unclear. Our data revealed that RON is upregulated in HRPCA cell lines and human prostate tumors. Using genetic approaches we found novel, causal association between RON and FLICE-like inhibitory protein, also known as FLIP (a known target of 2-ME2), and an increase in Death Associated Protein Kinase (DAPK1). Interestingly, RON overexpression in early stage PCA cell lines induced the transcriptional activation of the Androgen Receptor (AR) and FLIP. Stimulation of RON with its ligand MSP (macrophage stimulating protein) also yielded heightened promoter activity of AR and its downstream target genes including PSA and FLIP. Functionally, these responses translated to increased cell migration in RON overexpressing cells and loss of this migratory potential with RON silencing. Interestingly, 2-ME2 treatment also reduced the migration of HRPCA cells. Migration in wild-type HRPCA cells is also sensitive to regulation with 2-ME2 treatment. Overall these data suggests that RON kinase is a major player in promoting advanced-stage prostate cancer in part due to its ability to regulate apoptosis through novel FLIP/DAPK1 interaction. Supported by NIH (CA 135451, APK). Citation Format: Izhar S. Batth, Jingjing Gong, A. Pratap Kumar. Novel interaction between FLIP/DAPK: role for RON in androgen-independent prostate cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2954. doi:10.1158/1538-7445.AM2013-2954
Allergy to Coriander A Case Report
Authors: Raimo Suhonen, Helena Keskinen, Fred Björkstén, Eero Vaheri, Antti Zitting
Journal: Allergy (1979)

After 3 years of occupational exposure to powdered coriander ‐ a spice ‐ a woman developed respiratory symptoms of immediate hypersensitivity. Skin tests, nasal and bronchial challenge tests and the RAST were positive to coriander. Column chromatography, enzymatic digestion of the fractions and skin testing suggested that the allergen is a protein.
Pollen Sensitivity in 100 Asthmatic Children
Authors: Lewis Webb Hill
Journal: New England Journal of Medicine (1948)

IT IS well known that pollen sensitivity is common in asthmatic children. The full importance of this, however, is not generally appreciated, and in most textbooks and other discussions of asthma in childhood more emphasis is given to such allergens as house dust, animal danders and foods than to pollens. In my experience pollen sensitization and the common infectious cold are the two most frequent causes of asthmatic attacks in children, and the number of cases that are helped by removal of a cat, a mattress or some food is small indeed when compared with those in which the attacks . . .
Direct Evidence That Initial Oxidative Stress Triggered by Preconditioning Contributes to Second Window of Protection by Endogenous Antioxidant Enzyme in Myocytes
Authors: Xiaobo Zhou, Xiaolin Zhai, Muhammad Ashraf
Journal: Circulation (1996)

Background We tested the hypothesis that late preconditioning is associated with increased antioxidant enzyme activity induced by initial oxidative stress. Methods and Results Isolated rat myocytes were preconditioned either with two cycles of 5 minutes of anoxia and 5 minutes of reoxygenation or with exogenous superoxide anion (O 2 − ) generated by reaction of xanthine oxidase with xanthine. Myocytes were allowed to recover for 60 minutes or 24 hours, after which they were subjected to 60 minutes of anoxia and 60 minutes of reoxygenation. After 60 minutes or 24 hours, the protection was evidenced by decreased O 2 − production, increased Mn superoxide dismutase (Mn-SOD) activity, increased cell viability, decreased LDH release, reduced malondialdehyde formation, high-energy phosphate preservation, and improved cell morphology in preconditioned and O 2 − -treated myocytes. Immediately after treatment with O 2 − or repetitive, brief anoxia, O 2 − production was increased in myocytes. Longer anoxia resulted in loss of Mn-SOD activity in anoxic controls 24 hours later, whereas it was significantly increased in preconditioned and O 2 − -treated myocytes. O 2 − production was inhibited in preconditioned and O 2 − -treated myocytes. Myocytes treated with Mn-SOD during short, intermittent anoxia exhibited decreased activity of Mn-SOD and increased O 2 − production 24 hours later. Mn-SOD activity in late preconditioning was considerably higher than that in classic preconditioning. Conclusions These results suggest that a burst of oxygen free radicals generated during the initial periods of brief, repetitive anoxia increases myocardial antioxidant activity 24 hours later and that it contributes to the late cardioprotective effect of preconditioning.
Training and reaccreditations in general practice
Authors: G C S Reynolds
Journal: BMJ (1994)

EDITOR, - Once again the Royal College of General Practitioners has sold the profession down the river.1 When questioned about the demands of the government quangos of family health services authorities and trusts that general practitioners should spend 11 years in training to meet the quango's requirements the president of the college agrees that “general practitioners should be brought up to speed to cope with the modern situation.”

The half of graduates who are women would have to be fully trained before having children. As locums would have to …
Psychosomatic Studies of Allergic Disorders
Authors: Yukihiro Agg, Hideki Teshima, Shoji Nagata, Sadahisa Inoue, Yujiro Ikemi
Journal: Psychotherapy and Psychosomatics (1979)

It is generally conceded that allergic disorders occur in individuals who have a hereditary or congenital allergic constitution. Clinical symptoms of allergic disorders, however, often disappear due to changes of the individuals' life situations and/or their adaptive patterns. In a comparative study of allergic predisposition in students with allergic disorder (asthmatics) and students who had become completely free from childhood asthma for more than 3 years, without specific treatment, there was no significant difference in allergic predisposition between the two groups. The same tendency was also found between adult patients with allergic disorder (asthmatics) and persons who had shown complete remission for more than 3 years, having had psychosomatic treatment. These findings suggest that allergic predisposition does not influence the prognosis of allergic disorders as much as do socio-psychological factors. It is thought that the effect of psychosomatic treatment reconditions these socio-psychological factors which disturb homeostatic balance and which facilitate the clinical manifestation based on the allergic predisposition.
Population-based study of non-typable Haemophilus influenzae invasive disease in children and neonates
Authors: T.J. Falla, D.W.M. Crook, W.A.G. Kraak, W.W. Nichols, E.C. Anderson, J.Z. Jordens, M.P.E. Slack, S.R.M. Dobson, E.R. Moxon, D. Mayon-White
Journal: The Lancet (1993)
Effects of Cyclic GMP‐Agonists on Ciclosporin‐Induced Suppression of Human Lymphokine Production
Authors: M. Svenson, K. Bendtzen
Journal: Allergy (1985)

Ciclosporin (Cs) inhibits the elaboration of the lymphokine leukocyte migration inhibitory factor (LIF) from human blood mononuclear cells (MNC) stimulated with recall antigen. This inhibition was counteracted by 3 × lO ‐5 M dibutyryl‐cyclic GMP and 8‐bromo‐eyclic GMP and by the cyclic GMP‐agonists, sodium nitroprausside (NaNPr), ascorbic acid (As A), sodium azide (NaN 3 ) and carbacholine. Using 5 × 10 ‐5 M NaNPr, 1 × 10 ‐3 M NaN 3 , or 3 × 10 ‐3 M As A, 25–50‐, 4–8‐ and 2–3‐fold elevations of MNC and T‐lymphocyte cyclic GMP‐levels were obtained independently of the presence of Cs. NaNPr was the most potent of these three cyclic GMP‐agonists in counteracting the effect of Cs. The results indicate that intracellular cyclic GMP is a major factor involved in the reversal of Cs induced inhibition of LIF‐production. None of the cyclic GMP‐analogues or ‐agonists by themselves possessed Interleukin 1‐like activity, measured by their ability to induce LIF‐production by macrophage‐depleted T‐lymphocytes challenged by recall antigen.
Breast Cancer Screening
Authors: Harold C. Sox
Journal: Annals of Internal Medicine (2003)

Letters15 April 2003Breast Cancer ScreeningHarold C. Sox, MDHarold C. Sox, MDEditor(Sox)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-8-200304150-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Kopans raises a familiar question: Why do people refer to age 50 as a significant age for breast cancer screening when it has no biological significance? The answer is that this age is a proxy for the occurrence of natural menopause. Ideally, the clinical trials of breast cancer screening would have reported their results according to menopausal status at the time of screening but, to my knowledge, they did not. Dr. Kopans points out that there are no data that indicate a relationship between screening results and menopause. The reader should note that no data does not ...References1. Miller AB, To T, Baines CJ, Wall C. The Canadian National Breast Screening Study-1: breast cancer mortality after 11 to 16 years of follow-up. A randomized screening trial of mammography in women age 40 to 49 years. Ann Intern Med. 2002;137:305-12. [PMID: 12204013] LinkGoogle Scholar2. Nystrm L, Andersson I, Bjurstam N, Frisell J, Nordenskjld B, Rutqvist LE. Long-term effects of mammography screening: updated overview of the Swedish randomised trials. Lancet. 2002;359:909-19. [PMID: 11918907] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Editor(Sox) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Canadian National Breast Screening Study-1: Breast Cancer Mortality after 11 to 16 Years of Follow-up: A Randomized Screening Trial of Mammography in Women Age 40 to 49 Years Anthony B. Miller , Teresa To , Cornelia J. Baines , and Claus Wall Screening Mammography for Younger Women: Back to Basics Harold Sox The Canadian National Breast Screening Study-1: Breast Cancer Mortality after 11 to 16 Years of Follow-up: A Randomized Screening Trial of Mammography in Women Age 40 to 49 Years Anthony B. Miller , Teresa To , Cornelia J. Baines , and Claus Wall Breast Cancer Screening Daniel B. Kopans Metrics Cited ByReferences 15 April 2003Volume 138, Issue 8Page: 690KeywordsBreast cancerBreast cancer screeningClinical trial reportingMenopause ePublished: 15 April 2003 Issue Published: 15 April 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...