tbuckley/cabot-search huggingface dataset:
Principles of Clinical Neurology
Authors: Alexander T. Ross
Journal: JAMA (1965)

This is a lucid, fluent, well-organized textbook on the principles of neurological diagnosis with concise accounts of the more commonly encountered disorders of the nervous system. Emphasis is placed on the anatomy, physiology, and pathophysiology operative in diseases of the peripheral and central nervous systems as well as in those disorders of muscle seen by the neurologist. Application of these principles, within the context of the clinical disorders discussed, provides a structure for their better understanding. The book is not, nor does the author claim it to be, encyclopedic. The discussions of neurological conditions likely to be encountered by students and clinicians are informative and not burdened by distracting detail. Ancillary diagnostic procedures reflect current knowledge and experience. The photographic reproduction of radiograms is excellent. Suggestions for treatment are practical, and, where no specific therapy is known, this is frankly acknowledged. The author achieves his purpose of providing principles which
Photochemotherapy and topical nitrogen mustard in the treatment of mycosis fungoides
Authors: ANTHONY DU VIVIER, DOROTHY I. VOLLUM
Journal: British Journal of Dermatology (1980)

Eight patients with mycosis fungoides limited to the skin have been treated with either topical nitrogen mustard alone or in combination with photochemotherapy. This regime does not prevent contact sensitization to nitrogen mustard but will clear sanctuary sites of disease which may develop when photochemotherapy is used alone.
Right Pulmonary Vein Occlusion Detected by Ventilation -Perfusion Lung Scanning
Authors: MICHAEL F. HARTSHORNE, JOHN M. BAUMAN, MICHAEL A. CAWTHON, MICHAEL HUGGINS
Journal: Clinical Nuclear Medicine (1985)

Absence of perfusion of a right lung was initially misinterpreted as pulmonary embolic disease. Pulmonary angiography revised this diagnosis to obstruction of the right pulmonary vein.
Computerized Management of the Outpatient Diabetic
Authors: Robert E. Bolinger
Journal: JAMA (1971)

Examination of a semi-automated management system for the outpatient diabetic includes criteria for its performance, and a management module based on information obtained at the patient visit along with examples of the output prescription. The changes in insulin recommended by the computer agreed with those of the physician in most instances (<i>r</i>= 0.98), and in no instance did the computer make hazardous recommendations.
Extraversion, sexual experience, and sexual emotions
Authors: John Marshall Townsend
Journal: Behavioral and Brain Sciences (1999)

Sex differences in motivation and emotional reactions to casual sex suggest that the links to extraversion, constraint, impulsivity-sensation seeking, and sexual behavior differ for men and women. Because both testosterone and dominance, and dominance and number of sex partners appear to correlate in men but not in women, it is plausible that testosterone is involved in the creation and maintenance of these sex differences in linkage among the behavioral subsystems involved in sexuality and extraversion.
Self-induced paraffinoma in a schizophrenic patient
Authors: Marina Rodríguez-Martín, Miguel Sáez-Rodríguez, Jose Luis Carrasco, Ana Carnerero, Roberto Cabrera, Nuria Pérez-Robayna, Desiré Díaz Melián, Rosalba Sánchez, Marta García Bustínduy, Antonio Noda
Journal: Journal of the American Academy of Dermatology (2007)
Electrocardiographic Characteristics of Acute Coronary Syndromes with Culprit Lesion Localized in the Circumflex Artery
Authors: Burcak Kilickiran Avci, Ece Yurtseven, Sevgi Ozcan, Barıs Ikitimur, Bilgehan Karadag, Vural Ali Vural, Zeki Ongen
Journal: Journal of the American College of Cardiology (2013)
COMPLICATIONS AND DEGENERATIONS OF UTERINE FIBROMYOMATA.A PATHOLOGIC AND STATISTICAL STUDY OF TWO HUNDRED AND EIGHTY CASES.
Authors: ELLICE M'DONALD
Journal: JAMA (1904)

<h3>INTRODUCTION.</h3> Recent discussions in the surgical and gynecologic branches of the American, British and French medical organizations indicate a renewed interest in the question of treatment of uterine fibromyomata. This is due largely to facts brought forth as the result of the systematic routine pathologic examination of all fibroid tumors. The frequency with which fibroid tumors present degenerations and are accompanied by complications has upset the classical teaching in regard to prognosis and treatment of these growths. More particularly has interest been stimulated in regard to the so-called "malignant degenerations," as is evidenced by the prominent place which carcinoma and sarcoma occupy in recent publications on myoma. At present, however, the results of pathologic studies are not definitely collected, and there is a lack of statistical comparison. The importance of bringing together such results is evident, for the question of operative interference and extent of operation must depend on information
1056 MK-7009 SIGNIFICANTLY IMPROVES RAPID VIRAL RESPONSE (RVR) IN COMBINATION WITH PEGYLATED INTERFERON ALFA-2A AND RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C (CHC) GENOTYPE 1 INFECTION
Authors: M.P. Manns, E. Gane, M. Rodriguez-Torres, A. Stoehr, C.-T. Yeh, R. Wiedmann, P. Hwang, E. Quirk, J. Silber, A. Lee
Journal: Journal of Hepatology (2009)
Imaging allergen-invoked airway inflammation in atopic asthma with [18F]-fluorodeoxyglucose and positron emission tomography
Authors: I.K Taylor, M Hayes, B.J O'Connor, H.A Jones, J.M.B Hughes, N.B Pride, A.A Hill, K.M O'Shaughnessy, C.G Rhodes, T Jones, R.W Fuller
Journal: The Lancet (1996)
"Double Fistula" Bronchopleural and Pleurocutaneous During Radioxenon Study
Authors: EDWARD B. CRONIN, NAZLI ERBAY, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1997)

A woman had a right pneumonectomy, complicated 5 years later by an anaerobic infection with a following"blowout" of the bronchial stump; an empyema developed. A muscle graft was used to close the bronchial stump. An Eloesser flap was created to allow drainage of the empyema. She was later admitted with respiratory distress. A ventilation lung scan was performed with Xe-133. This showed the results of a "double fistula," with passage of radioxenon into the right pleural space and then out of the body through the Eloesser flap.
Assessment of anti-stratum corneum antibody titres in pustulosis palmaris et plantaris
Authors: K. DANNO, H. OKAMOTO, S. IMAMURA AND, S. OFUJI
Journal: British Journal of Dermatology (1982)

Titres of anti-stratum corneum (SC) antibodies, determined by an indirect immunofluorescence (IF) technique, were significantly higher on average in pustulosis palmaris et plantaris (PPP) and pompholyx than in normal controls. By a complement IF technique, the antibodies fixed complement (C3) in high titer in PPP, but to a much lesser degree in pompholyx and normal controls. Direct IF microscopy studies showed the deposition of IgG and C3 in the SC in some of the biopsy specimens of the pustular lesions. These findings suggest that in PPP anti-SC antibodies may be involved at least in part in activation of the complement system and the subsequent accumulation of polymorphonuclear leukocytes.
Magical Medicine: A Nigerian Case-Study
Authors: Wayne Callaway
Journal: JAMA (1972)

The modern physician in Africa often experiences great frustration in the face of his patients' continued reliance upon traditional practices and practitioners. Dr. MacLean's monograph should help him understand what he is up against. Based upon interviews, questionnaires, and first-hand observations that the author carried out in the early 1960's,<i>Magical Medicine</i>surveys the various forms of medical care available to the inhabitants of Ibaden, Nigeria. The author outlines the beliefs underlying traditional concepts of health and disease, and describes how illness might be interpreted in the daily life of a Yoruba family. She presents data regarding Ibaden's hospitals, beds, Westerntrained physicians, traditional practitioners, etc. (Unfortunately, eight years and the Biafran war have brought important changes in the factors she attempted to measure.) The remainder of the book catalogues various folk remedies and the conditions for which they are prescribed; class differences in the use of traditional practices; and reasons
Full results on risks of epoetin emerge 14 years after major dialysis study
Authors: K. Epstein
Journal: BMJ (2012)

More than 14 years after the publication of a major clinical trial of the use of epoetin alfa in patients undergoing haemodialysis, a new analysis of contemporaneous data obtained under the US Freedom of Information Act has found that researchers under-reported serious adverse effects and overstated the benefits of high doses of the drug. Epoetin alfa was later shown in other studies to pose a risk of heart attack and death.

The new retrospective analysis, published in March in the International Society of Nephrology’s journal Kidney International ,1 raises questions about whether the medical profession and US authorities had been misled by what seems to have been an incomplete report on experimental results and whether enough scientific transparency and regulatory oversight accompanied the development of new drugs and devices.

Specifically, the original study, called the normal haematocrit trial, which was published in August 1998 in the New England Journal of Medicine and was the largest comparison of epoetin ever …
Hepatic haemangiomas: possible association with female sex hormones
Authors: V Glinkova
Journal: Gut (2004)

The association of hepatic haemangiomas with female sex hormones is not entirely clear. We prospectively evaluated the impact of female sex hormones on the natural history of liver haemangiomas.We followed 94 women with 181 haemangiomas diagnosed by ultrasound for a period of1-17 years (mean 7.3 (5.5) years). The location, number, size, and ultrasonographic pattern of the lesions were evaluated. Patients were also evaluated by questionnaire for gynaecological and reproductive history. We compared the change in number and size of haemangiomas in patients who received or did not receive exogenous hormonal treatment.Age at first period was inversely associated with the size of haemangiomas (r = 0.181, p = 0.015) while age at menopause was positively correlated with the number of haemangiomas detected at first ultrasound (r = 0.542, p<0.0001). During follow up, no change in the ultrasonographic pattern or number of haemangiomas was observed. An increase in the size of the lesions was demonstrated in 5/22 (22.7%) hormone therapy exposed patients compared with 7/72 (9.7%) controls. Three variables (ultrasonographic pattern, number of haemangiomas, and hormone therapy) predicted whether or not a given haemangioma would increase in size. A hypoechoic pattern increased the risk of progression while a hyperechoic pattern decreases that risk (p = 0.003). The number of haemangiomas was inversely associated with the likelihood of progression (p = 0.006) and hormone therapy increased the risk of haemangioma enlargement (p = 0.05).Hepatic haemangiomas seem to be influenced by both endogenous and exogenous female sex hormones although significant enlargement occurs only in a minority of patients. Consequently, routine liver ultrasound follow up in women with hepatic haemangiomas receiving hormone therapy appears appropriate.
Mental Health Theme Issue
Authors: Richard M. Glass
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
the question of the assumed givenness of the singularity of the target
Authors: edmond wright
Journal: Behavioral and Brain Sciences (2005)

interesting as the experiments are, their relevance to the real-life situation is rendered questionable by the unthinking use of given singularities as target objects. the evolutionary process does not respect what one agent takes to be a singular referent. a “singling” from the continuum is rather a varying feature of the necessity to track what is rewarding in it.
Title for Painting Corrected
Authors: Nicholas Nickou
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I must disagree with the title,<i>Prefontaine Winning Half-Mile</i>, for the cover illustration of the July 12 issue ofThe Journal. This was more likely either the 5 km or 10 km event, which were more the choice of the great Prefontaine. He was outstanding from 1 to 6 miles, but not in the half-mile. The two runners in the lead were most likely Tracy Smith and Frank Shorter.
IMMUNIZATION OF GUINEA PIGS WITH A MODIFIED STRAIN OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS
Authors: Erich Traub
Journal: The Journal of Experimental Medicine (1937)

A strain of choriomeningitis virus which was highly virulent for guinea pigs, as isolated from a naturally infected white mouse, has been markedly attenuated for guinea pigs by serial intracerebral passage through white mice. The change of virulence occurred before the 8th serial passage. The modified virus as a rule produces fever in guinea pigs but no other symptoms, and the infection is followed by a very solid immunity. Parallel passages of the same strain through guinea pigs have maintained its high virulence for this species but slightly reduced its pathogenicity for mice. These observations indicate that the differences in virulence for guinea pigs noted before (1, 2) with different strains of choriomeningitis virus obtained from infected stock mice may be due not only to differences in the susceptibility of guinea pigs but also to variations in the virulence of the virus. A marked degree of resistance was demonstrable in several guinea pigs on the 4th, 8th, and 10th day after injection with modified virus, when antivirus could not yet be detected in the serum. Circulating antivirus appears therefore to play a secondary part in their immunity, which seems to be closely associated with the tissues as in mice.
New thoughts for the Health Education Council
Authors: B. Bailey, D. A Player
Journal: BMJ (1983)

<h3>Background</h3> Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-acquired pneumonia (VAP). However, successful validation of the usefulness of potential markers in this setting is exceptionally rare. <h3>Objectives</h3> We sought to validate the capacity for specific host inflammatory mediators to exclude pneumonia in patients with suspected VAP. <h3>Methods</h3> A prospective, multicentre, validation study of patients with suspected VAP was conducted in 12 intensive care units. VAP was confirmed following bronchoscopy by culture of a potential pathogen in bronchoalveolar lavage fluid (BALF) at &gt;10<sup>4</sup> colony forming units per millilitre (cfu/mL). Interleukin-1 beta (IL-1β), IL-8, matrix metalloproteinase-8 (MMP-8), MMP-9 and human neutrophil elastase (HNE) were quantified in BALF. Diagnostic utility was determined for biomarkers individually and in combination. <h3>Results</h3> Paired BALF culture and biomarker results were available for 150 patients. 53 patients (35%) had VAP and 97 (65%) patients formed the non-VAP group. All biomarkers were significantly higher in the VAP group (p&lt;0.001). The area under the receiver operator characteristic curve for IL-1β was 0.81; IL-8, 0.74; MMP-8, 0.76; MMP-9, 0.79 and HNE, 0.78. A combination of IL-1β and IL-8, at the optimal cut-point, excluded VAP with a sensitivity of 100%, a specificity of 44.3% and a post-test probability of 0% (95% CI 0% to 9.2%). <h3>Conclusions</h3> Low BALF IL-1β in combination with IL-8 confidently excludes VAP and could form a rapid biomarker-based rule-out test, with the potential to improve antibiotic stewardship.
Abstract 1297: DDAIP improves the pharmacokinetic profile of PrevOnco® in different species: Comparison of DDAIP, CMC and PEG-300/400 formulations in mice, beagle dogs and cynomolgus monkeys
Authors: Kevin Dines, Francesca Incardona, Mohamed Hachicha, Richard Martin, Bassam Damaj
Journal: Cancer Research (2011)

Abstract Our study in the accompanying abstract demonstrates that a low dose of PrevOnco® in combination with doxorubicin was efficacious in a liver cancer model. In this study we investigated the pharmacokinetic profile of PrevOnco® when formulated with 20% DDAIP or 20% PEG-300 in mice, dogs and cynomolgus monkeys. The goal was to evaluate the potential of formulation in DDAIP to increase PrevOnco® exposure in vivo. Methods: PK plasma analyses of PrevOnco® administered orally at 100 mg/Kg in 1% carboxy methyl cellulose (CMC) or in 10% PEG-400 were evaluated in nude mice. 20% PEG-300 and 20% DDAIP formulations were evaluated in mice (100 mg/Kg), dogs (5 mg/Kg) and monkeys (5 mg/Kg). Results: Compared to 20% PEG-300, administration of PrevOnco® in 20% DDAIP induced 7-fold, 8-fold and 2-fold improvements in AUC in mice, dogs and cynomolgus monkeys, respectively. In mice, Cmax reached 4,700 ng/mL in DDAIP compared to 1,000 ng/mL in PEG-300 formulation. PrevOnco® levels were detectable up to 4 hours in DDAIP compared to 2 hrs in PEG-300. In dogs, PrevOnco® in 20% PEG-300 formulation had a Cmax of 125 ng/mL at Tmax = 1 hr. This concentration was maintained up to 2 hrs with levels undetectable at 4 hrs. PrevOnco® in 20% DDAIP formulation had a Cmax of 1,600 ng/mL at Tmax=1 hr and T1/2=3hrs. AUC values were 3,941 and 477 for DDAIP and PEG, respectively. In monkeys, PrevOnco® plasma levels following 5 mg/Kg oral administration reached a Cmax of 120 ng/mL in 20% DDAIP and 90 ng/mL in 20% PEG-400. Tmax was 1 hour and 0.5 hour while AUCs were 390 versus 154 (both DDAIP vs. PEG-400). Conclusion: Formulating with DDAIP increased plasma levels of PrevOnco® following oral administration in mice, dogs and monkeys. Thus, DDAIP facilitated higher Cmax and AUC values as well as a longer T1/2. DDAIP formulation will allow a lower dose of PrevOnco® to be used while maintaining efficacy and reducing cytotoxicity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1297. doi:10.1158/1538-7445.AM2011-1297
Regulating Firearm Advertisements That Promise Home Protection
Authors: Jon S. Vernick, Stephen P. Teret, Daniel W. Webster
Journal: JAMA (1997)

Firearms are a consumer product responsible for 38500 deaths in the United States in 1994. Like other products, firearms are advertised. In the absence of rules governing the design of firearms, regulating the way guns are advertised may be a useful public health intervention. Some gun advertisements include messages suggesting that bringing a handgun into the home is generally protective for the occupants of the home. The best available scientific information contradicts this message. Given this disjunction, regulating those advertisements may be an appropriate response. Under federal law, the Federal Trade Commission (FTC) has authority to prohibit advertisements that are "deceptive" or "unfair." Under the FTC's deception analysis, the focus is on whether consumers are misled by an advertisement. For a finding of unfairness, the FTC looks for advertisements that may cause substantial injury to consumers. Under either analysis, a strong argument can be made that firearm advertisements promising home protection are unlawful. On February 14, 1996, several organizations sent separate petitions to the FTC asking it to consider the issues raised by firearm advertisements that promise home protection. The FTC is still reviewing the information presented. There are no First Amendment or Second Amendment impediments to FTC regulation of deceptive firearm advertising under the US Constitution.
Rising HIV-Related Mortality in Young Americans
Authors: Sten H. Vermund
Journal: JAMA (1993)

In this issue ofTHE Journal, Selik et al<sup>1</sup>report that disease attributable to the human immunodeficiency virus (HIV) was the No. 1 cause of death among young men 25 to 44 years of age in 64 US cities in 1990. Nationwide, HIV infection was the second leading cause of death in men aged 25 to 44 years. In Florida, for example, HIV infection was the leading cause of death for young men statewide in 1990, and HIV infection led all other causes of death in the cities of Hialeah, Hollywood, Fort Lauderdale, Miami, Orlando, St Petersburg, and Tampa. Nationwide, cities reporting HIV infection as the No. 1 cause of young male deaths were as diverse as Arlington, Va; Baton Rouge, La; Columbia, SC; Indianapolis, Ind; Jackson, Miss; Minneapolis, Minn; Pasadena, Calif; Raleigh, NC; Springfield, Mo; Stamford, Conn; and Syracuse, NY. Among women aged 25 See also p 2991.
The Necessity for Adding Albumin to Serum in Crossmatching
Authors: Morten Grove-Rasmussen, Lamar Soutter
Journal: New England Journal of Medicine (1953)

THE "serum method" of crossmatching has been described in detail by Soutter, Allen and Emerson.1 According to the authors: "This method has not failed to demonstrate high-titered 'albumin-active' anti-Rh in a serum regardless of the possible presence of prozone, when ordinary Rh-positive bloods were used."Recently, in work with the serum of a person highly sensitized to the Rh factor, the "serum method" of crossmatching failed to disclose incompatibility with Rh-positive blood. Because of this experience and a subsequent similar one, we consider it essential to withdraw the statement quoted above, particularly because the "serum method" is now being widely . . .
The Creation of Adam: Divine Funster Decrees We Are What We Eat: Chicken?-Reply
Authors: F. L. Meshberger
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal