tbuckley/cabot-search huggingface dataset:
The Mating-induced Release of Prolactin: A Unique Neuroendrocine Response*
Authors: JOSEPH W. GUNNET, MARC E. FREEMAN
Journal: Endocrine Reviews (1983)

I. Introduction IN THE RAT, the corpus luteum is formed on the morning of estrus in response to the surge of luteinizing hormone released on the previous day, proestrus. However, unlike other mammals whose corpora lutea secrete increasing amounts of progesterone for several days (1), the newly formed corpora lutea of the rat secrete progesterone for only 2 days after formation (2, 3). In the absence of all other input, the corpora lutea subsequently fail and progesterone secretion wanes (3). It has long been appreciated that rodent corpora lutea could be maintained by either coital stimulation (4) or injection of pituitary extracts containing prolactin (PRL) activity (5, 6). An overwhelming literature now indicates that the mating stimulus induces the release of PRL which in turn “rescues” the corpora lutea of the cycle and prolongs the ability of these structures to secrete progesterone (3, 7–11). The mating stimulus or copulomimetic stimuli applied to the uterine cervix with a glass rod or appropriately...
Action of a Pyrimido-pyrimidine Compound on Platelet Behaviour in Vitro
Authors: C. D. Forbes, G. P. McNicol, A. S. Douglas
Journal: BMJ (1969)

A pyrimido-pyrimidine compound (RA433) was found in vitro to be a significantly more potent inhibitor of platelet behaviour than the previously available pyrimido-pyrimidine compound RA8-dipyridamole. In a turbidimetric system RA433 inhibits platelet aggregation induced by adenosine diphosphate, collagen, and noradrenaline; further, in a glass-bead-column technique it is a powerful inhiitor of platelet adhesiveness.
THE RACIAL FACTOR IN BASAL METABOLISM
Authors: EDWARD L. TURNER
Journal: JAMA (1926)

During the last three or four years, various investigators have called attention to the fact that the basal metabolism standards, as based on the Harris and Benedict, and the Aub and Du Bois prediction tables, cannot be used everywhere without certain modifications and corrections. In a report of some work done on Chinese students four years ago, Earle<sup>1</sup>states that the metabolic rate of the Chinese was set at a lower level than that of western subjects. Yano<sup>2</sup>states that low metabolism is probably a characteristic of the Japanese race, and Takahira<sup>3</sup>also reports an average metabolic rate of Japanese somewhat lower than that expected according to the American prediction tables. In two recent papers, MacLeod, Crofts and Benedict<sup>4</sup>have brought up the question of the racial factor as playing a rôle in metabolic rate. These investigators performed experiments on nine young Chinese and Japanese women
Interferon alfa down-regulates CD81 in patients with chronic hepatitis C
Authors: Bernd Kronenberger, Brigitte Rüster, Robert Elez, Stephan Weber, Albrecht Piiper, Jung-Hun Lee, Kurt W. Roth, Stefan Zeuzem
Journal: Hepatology (2001)

CD81 protein has been shown to bind hepatitis C virus (HCV) envelope 2 (E2) glycoprotein in vitro and may act as a (co)receptor for HCV. Regulation of CD81 expression by interferon alfa (IFN-alpha) and ribavirin could thereby affect the response to antiviral therapy. In the present study, the effects of IFN-alpha and ribavirin on CD81 protein and CD81 mRNA were assessed in peripheral blood lymphocytes (PBL) and isolated human hepatocytes by fluorescence-activated cell sorter (FACS) analysis and real-time polymerase chain reaction (PCR), respectively. In addition, regulation of CD81 in PBL was investigated in 10 patients treated with combination therapy. Incubation with IFN-alpha (50 U/mL) down-regulated total CD81 in PBL (81.7 +/- 11.6% of control; P =.003) and in isolated human hepatocytes (91.6 +/- 8.1% of control; P =.034). Incubation with IFN-alpha with and without ribavirin (2.2 microg/mL) significantly reduced cell surface-associated CD81 protein (83.9 +/- 10.3% of control; P =.003). PBL of untreated patients chronically infected with HCV had significantly higher levels of total CD81 protein compared with PBL obtained from healthy donors (631.1 +/- 93.3 vs. 538.9 +/- 95.2 relative fluorescence units [RFU]; P =.030). Pretreatment cell surface-associated CD81 protein was lower in patients infected with genotype HCV-3 than those infected with HCV-1 (111.8 +/- 15.0 vs. 162.0 +/- 41.3 RFU; P =.019). Furthermore, cell surface-associated CD81 protein was lower 4 weeks after initiation of therapy in patients with an initial virologic response compared with initial virologic nonresponders (110.5 +/- 8.5 vs. 139.8 +/- 27.5 RFU; P =.057). In conclusion, IFN-alpha and ribavirin regulate CD81 expression in vitro and in vivo. CD81 expression correlates with HCV genotype and initial virologic response in patients with chronic hepatitis C.
OnabotulinumtoxinA Improves Health-Related Quality of Life in Patients With Urinary Incontinence Due to Idiopathic Overactive Bladder: A 36-Week, Double-Blind, Placebo-Controlled, Randomized, Dose-Ranging Trial
Authors: Clare J. Fowler, Stephen Auerbach, David Ginsberg, Douglass Hale, Piotr Radziszewski, Tomasz Rechberger, Vaishali D. Patel, Jihao Zhou, Catherine Thompson, Jonathan W. Kowalski
Journal: European Urology (2012)
Abstract 9446: Usefulness of Platelet Retention Assay for Diagnosing Acute Coronary Syndromes and Predicting Clinical Outcome in Patients with Chest Pain and/or Shortness of Breath
Authors: Keita Sano, Wataru Sugamata, Juntaro Deyama, Manabu Uematsu, Daisuke Fujioka, Takamitsu Nakamura, Yukio Saito, Yoshinobu Kitta, Jyn-ei Obata, Ken-ichi Kawabata, Kiyotaka Kugiyama
Journal: Circulation (2011)

Measurement of platelet retention rate (PRR) using a collagen-coated bead column and whole blood as a sample is a new point-of-care assay that reflects platelet aggregate formation. We have previously reported an equivalency of the PRR assay with PFA-100 and light-transmission aggregometry to assess the platelet function. This assay is very simple, low-cost performance and takes &lt; 5 min for all procedure. We tested the hypothesis that the PRR assay may be useful for early diagnosing acute coronary syndromes (ACS) and predicting clinical outcome in patients with chest pain and/or shortness of breath of uncertain origin. Methods and Results: The citrated whole blood (1.5 ml) in a syringe was passed through a column with collagen-coated beads (0.1-0.2 mm diameter) using a syringe pump. The PRR in the column was calculated by difference between platelet counts in the blood samples before and after the passage. As retention rate rises, so does platelet aggregability. The PRR was measured at admission in the 129 consecutive patients who were admitted for chest pain and/or shortness of breath of recent onset (&lt; 24 hrs). Of the enrolled patients, 59 (45%) patients had the discharge diagnosis of ACS, and the remaining 70 patients (55%) had non-ACS. The high PRR (&gt;30%, as determined by ROC analysis) provided 78% of sensitivity and 79% of specificity in identifying ACS patients, and the addition of PRR increased the diagnostic power of troponin T (TropT) and CKMB (AUC; combination with PRR 0.80 and 0.91 vs. without PRR 0.62 and 0.80, respectively, p &lt; 0.01). Cardiac events recurred after discharge in 16 patients (1 cardiac death, 1 non-fatal MI, and 14 coronary revascularization) during 1-year follow-up period. The higher PRR had a significant predictive value of the future events, that was independent of use of anti-platelet medications, TropT, C-reactive protein, brain natriuretic peptide (HR 2.2, 95% CI 1.3-71.9, p &lt; 0.01). The addition of PRR increased the predictive ability of TropT (AUC; combination with PRR: 0.80 vs. without PRR 0.62, p &lt; 0.01). Conclusions: In triage of patients with chest pain and/or shortness of breath, the platelet retention rate assay may be useful for fast diagnosis of ACS and early risk stratification along with other conventional biomarkers.
Limited Joint Mobility in Childhood Diabetes: Family Studies
Authors: Arlan L Rosenbloom, Janet H Silverstein, William J Riley, Noel K Maclaren
Journal: Diabetes Care (1983)

We examined 204 persons with insulin-dependent diabetes mellitus (IDDM), aged 7–23 yr, and 336 of their first-degree relatives, to determine whether there is a genetic component to the development of limited joint mobility. Simple and multiplex pedigrees with IDDM were studied along with normal controls. Only 1 of 90 normal controls had joint stiffness. Among 225 nondiabetic parents of children with IDDM, 7 (3%) had joint limitation, compared with 42 (21%) of children and youth with IDDM. Only 1 of 108 nondiabetic siblings of diabetic probands had limitation. Three parents had adult-onset diabetes and all had limited joint mobility. None of the 8 nondiabetic relatives with joint limitation had diabetic probands with joint involvement; 5 of these 8 tested were negative for islet cell auto-antibodies. There were 11 IDDM multiplex families with at least one member having joint limitation. The concordance rate for limited joint mobility of persons with diabetes for more than 5 yr who were over 12 yr of age was 56%, not different from the 48% frequency in patients with IDDM who met these age and duration criteria. Thus, evidence that limited joint mobility is a metabolic consequence of diabetes includes the virtual absence of limitation among first-degree relatives of probands, including probands with joint stiffness, and that the frequency of joint involvement is not increased in first-degree relatives of patients with IDDM. Furthermore, two brothers with pancreatic hypoplasia and a non-HLA-associated form of IDDM were affected with limited joint mobility. Nonetheless, the expression of this complication must be influenced by host factors, since not all persons with IDDM develop it, and those who do have variable ages of onset without correlation to control measures.
Not all noni liquid dietary supplements are created equal
Authors: 'Afa Kehaati Palu, None BrettWest, None Jarakae Jensen
Journal: American Journal of Hematology (2005)

To the Editor: Imatinib mesylate has tremendously changed the clinical course of chronic myeloid leukemia (CML).Higashi and co-workers reported two CML patients who had imatinib-sensitive blast crisis immediately after discontinuation of the drug due to neutropenia in a recent issue of the this journal [1].Herein we report two CML cases that developed extramedullary collection of myeloblasts during the imatinib treatment.
Bacteremia in Febrile Children Seen in a “Walk-in” Pediatric Clinic
Authors: John E. MCGowan, Lorna Bratton, Jerome O. Klein, Maxwell Finland
Journal: New England Journal of Medicine (1973)

Abstract In an effort to identify high-risk children blood for culture was obtained in children whose temperature was 38.3°C or higher when they were seen in the pediatric walk-in clinic. Clinically important bacterial pathogens were identified in the blood from 31 of 708 children in a three-month period. Diplococcus pneumoniae and Haemophilus influenzae were the most frequent of seven species identified. The data suggest that in this setting, a blood culture provides valuable help in establishing the specific bacteriologic diagnosis in febrile children without focal signs of infection. Bacteremia was most frequent in children seven to 12 months old (p<0.001) and was associated with a white-cell count of 20,000 or more (p<0.01)and a temperature of 39.4°C or higher (p<0.01). (N Engl J Med 288:1309–1312, 1973)
Functional Redundancy of the Nuclear Factor κB Inhibitors IκBα and IκBβ
Authors: Janet D. Cheng, Rolf-Peter Ryseck, Ricardo M. Attar, Donna Dambach, Rodrigo Bravo
Journal: The Journal of Experimental Medicine (1998)

The transcription factor NF-kappaB is sequestered in the cytoplasm by the inhibitor proteins of the IkappaB family. Each member of the IkappaB exhibits structural and biochemical similarities as well as differences. In an effort to address the functional redundancy of two closely related IkappaB molecules, IkappaBalpha and IkappaBbeta, we generated knock-in mice by replacing the IkappaBalpha gene with the IkappaBbeta gene. The knock-in mice do not express IkappaBalpha, but express a T7-tagged IkappaBbeta under the promoter and regulatory sequence of ikba. Unlike the IkappaBalpha-deficient mice, which display severe postnatal developmental defects and die by postnatal day 8, homozygous knock-in mice survive to adulthood, are fertile, and exhibit no apparent abnormalities. Furthermore, thymocytes and embryonic fibroblasts from the knock-in animals exhibit an inducible NF-kappaB response similar to that of wild-type animals. These results indicate that IkappaBalpha and IkappaBbeta share significant similarities in their biochemical activity, and that they acquired their different functions from divergent expression patterns during evolution.
The Role of Physicians in the Future of Quality Management
Authors: D Blumenthal, A M Epstein
Journal: New England Journal of Medicine (1996)

Previous articles in this series discussed alternative ways to define the quality of health care,1 state-of-the-art methods for measuring and improving quality,2,3 the origins of the quality debate,4 and the implications of capitated payment arrangements for the quality of care.5 Many readers may remain unsure, however, about how efforts to measure and manage quality in our health care system will evolve, and about how physicians should respond. In this concluding article in the series, we review some likely near-term developments in society's continuing efforts to improve the quality of care, and we discuss their implications for physicians and their . . .
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2
Authors: Natalie J. Foot, Hazel E. Dalton, Linda M. Shearwin-Whyatt, Loretta Dorstyn, Seong-Seng Tan, Baoli Yang, Sharad Kumar
Journal: Blood (2008)
Subacute and long term effect of swimming training on blood pressure in young and old spontaneously hypertensive rats
Authors: K. NOMA, H. RUPP, R. JACOB
Journal: Cardiovascular Research (1987)

Journal Article Subacute and long term effect of swimming training on blood pressure in young and old spontaneously hypertensive rats Get access KENJI NOMA, KENJI NOMA From the Physiology Institute II, University of Tübingen, Tübingen, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar HEINZ RUPP, HEINZ RUPP From the Physiology Institute II, University of Tübingen, Tübingen, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar RUTHARD JACOB RUTHARD JACOB From the Physiology Institute II, University of Tübingen, Tübingen, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 12, December 1987, Pages 871–877, https://doi.org/10.1093/cvr/21.12.871 Published: 01 December 1987 Article history Accepted: 04 February 1987 Accepted: 06 June 1987 Published: 01 December 1987
Analysis of predictive factors for the outcome of complete lymph node dissection in melanoma patients with metastatic sentinel lymph nodes
Authors: Christian Kunte, Till Geimer, Jens Baumert, Birger Konz, Matthias Volkenandt, Michael Flaig, Thomas Ruzicka, Carola Berking, Monika-H. Schmid-Wendtner
Journal: Journal of the American Academy of Dermatology (2011)
Drugs for Emotional Disorders
Authors: Leo E. Hollister
Journal: JAMA (1975)

EMOTIONAL disorders, or what is termed "mental illness," may be both more frequent and more incapacitating than any other disease or disorder. Exact determinations of frequency are impossible, as many, if not most, instances are either unrecognized or unreported. A recent survey estimated that in any given year 15% of adults (about 20 million people) may suffer serious depressive symptoms.<sup>1</sup>Yet this is only one of many emotional disorders. At any given moment, almost 2 million people are under some formal treatment for emotional disorders, and psychiatrists now outnumber pediatricians and obstetricians. Most treatment is given by nonpsychiatrists, with probably one half of all visits to family or personal physicians being based on a primary or secondary emotional disorder. The degree of incapacity varies greatly. Where I live, suicides, accidents (often a pseudosuicide), and alcoholism (cirrhosis of the liver) rank high among the ten leading causes of death. Excluding
Biofeedback and Family Practice Medicine
Authors: Henry H. Stonnington
Journal: JAMA (1985)

<b>Biofeedback: Principles and Practice for Clinicians,</b>edited by John V. Basmajian, ed 2; 390 pp, with illus, $38.50, Baltimore, Williams &amp; Wilkins Co, 1983. The regular well-trained, knowledgeable internist and surgeon know what to expect after prescribing medications, fluids and electrolytes, surgical procedures, exercises, and nutritional advice. The physician is in control and makes things happen. When people mention biofeedback, hypnosis, self-regulation, and cybernetics, physicians commonly become defensive, mention quackery, and become uncomfortable. We are only now beginning to acknowledge the physiological basis and, therefore, the therapeutic value of mind control of bodily functions. The general population, too, is uncomfortable with the idea and would much rather go to a physician and say, "Heal me, Doctor." The idea that the patient is the one to do the healing, the self-regulating, is as difficult for the patient as it is for the physician. Both these books are excellent, and they complement
Anesthesia and Uncommon Pediatric Diseases
Authors: M. T. Clarke
Journal: JAMA (1987)

Dr Jordan Katz and colleagues in the Department of Anesthesia, University of California, San Diego, in 1981 presented the second edition of their book<i>Anesthesia and Uncommon Diseases: Pathophysiologic and Clinical Correlations</i>.<sup>1</sup>The first edition, published in 1973, had met a need in the anesthesia community for a compilation of the best basic science and clinical information then available regarding anesthetic management of uncommon medical and surgical conditions. The second edition, an update and expansion, recognized increasing subspecialization in anesthesiology and hence the need for a reference source regarding conditions that may have become uncommon for an individual practitioner. At about the same time, Dr David J. Steward, who was then chief of anesthesia at The Hospital for Sick Children, Toronto (he is now anesthetist-in-chief at British Columbia's Children's Hospital, Vancouver), produced his excellent<i>Manual of Pediatric Anesthesia</i>.<sup>2</sup>Both editions (1979 and 1985) are augmented by an appendix,
Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation
Authors: Cheuk Him Man, Tsz Kan Fung, Christa Ho, Heron H. C. Han, Howard C. H. Chow, Alvin C. H. Ma, William W. L. Choi, Si Lok, Alice M. S. Cheung, Connie Eaves, Yok Lam Kwong, Anskar Y. H. Leung
Journal: Blood (2012)
Increased levels of inflammatory cytokines in human skin lymph derived from sodium lauryl sulphate-induced contact dermatitis
Authors: T. HUNZIKER, C.U. BRAND, A. KAPP, E.R. WAELTI, L.R. BRAATHEN
Journal: British Journal of Dermatology (1992)

A superficial peripheral lymph vessel draining the skin of the upper and medial part of the foot was cannulated on the lower leg of six healthy human volunteers. After 2 days an irritant contact dermatitis was induced by application of 10% sodium lauryl sulphate to the area of skin drained by the lymph vessel. Three days later the spontaneously regressing skin reaction was treated with clobetasol propionate. Lymph was collected twice daily for 7 days, and the levels of various cytokines (IL‐1α, IL‐1β, IL‐2 and soluble IL‐2 receptors. IL‐6, IL‐8, TNF‐α, GM‐CSF) were determined by ELISA technique. In the majority of the volunteers all cytokines examined were detected in several lymph samples, with the exception of IL‐lα and IL‐8. In parallel with the clinical symptoms of the contact dermatitis the levels of IL‐6 and TNF‐α increased 8–l0‐fold, whereas for IL‐1β, IL‐2, IL‐2 receptors, and GM‐CSF there was a delayed, 2–3‐fold increase. These results suggest that cytokines, in particular IL‐6 and TNF‐α, may actively participate in the immunological reactions in the skin and in the regional lymph nodes during contact dermatitis.
Signaling Control by Epidermal Growth Factor Receptor and MET: Rationale for Cotargeting Strategies in Lung Cancer
Authors: Eric B. Haura, Matthew A. Smith
Journal: Journal of Clinical Oncology (2013)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2013.50.8234 Journal of Clinical Oncology - published online before print October 7, 2013 PMID: 24101046 Signaling Control by Epidermal Growth Factor Receptor and MET: Rationale for Cotargeting Strategies in Lung Cancer Eric B. HauraxEric B. HauraSearch for articles by this author , Matthew A. SmithxMatthew A. SmithSearch for articles by this author Show More H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL https://doi.org/10.1200/JCO.2013.50.8234 First Page Full Text PDF Figures and Tables © 2013 by American Society of Clinical Oncology
Abstract LB-172: Transgene presence in patients’ tumors following tumor-targeted nanodelivery
Authors: Kathleen F. Pirollo, John J. Nemunaitis, Neil N. Senzer, Leanne Sleer, Esther H. Chang
Journal: Cancer Research (2010)

Abstract Discussant: William F. Benedict, UT M. D. Anderson Center, Houston, TX. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-172.
Exogenous nitric oxide inhibits in vivo platelet adhesion following balloon angioplasty
Authors: P. H Groves, W. J Penny, H. A Cheadle, M. J Lewis
Journal: Cardiovascular Research (1992)

The aim was to investigate the effects of an exogenous source of nitric oxide on in vivo platelet adhesion at the site of endothelial denudation after balloon angioplasty.The study group consisted of 12 anaesthetised Large White pigs. Pigs were randomised to receive SIN-1 (3-morpholino-sydnonimine), an exogenous donor of nitric oxide, or placebo before and during balloon induced vessel wall injury. Platelet deposition was quantified using the injection of autologous 111indium labelled platelets. Platelet function was also monitored by the measurement of bleeding time and ex vivo whole blood aggregometry.Superficial vessel wall injury was confirmed histologically and platelet monolayer formation was demonstrated by scanning electron microscopy. Platelet deposition at the site of endothelial denudation was markedly reduced following SIN-1 administration compared to placebo: 1.266(SEM 0.063) v 1.732(0.060) log platelets x 10(5).cm-2, p = 0.001. SIN-1 raised platelet cyclic GMP concentration, from 4.47(2.48) to 6.14(2.44) pg.platelet-1 (p less than 0.01) and prolonged the bleeding time, from 135(5) to 202(6) s (p = 0.001), but had non-significant effects on ex vivo whole blood aggregometry.Exogenous nitric oxide, through the activation of platelet soluble guanylate cyclase, inhibits platelet adhesion in vivo following balloon angioplasty.