tbuckley/cabot-search huggingface dataset:
VALUE OF VACCINATION AGAINST INFLUENZA
Authors: Benjamin S. Paschall
Journal: JAMA (1918)

<h3>To the Editor:</h3> —I cannot resist the impulse to reply to your editorial on "Serums and Vaccines in Influenza" (The Journal, Oct. 26, 1918, p. 1408). The medical profession, quite justly proud of its conservatism, is sometimes guilty of carrying it to extremes. We rarely seem to be willing to take an assumption at its face value. Your editorial begins by saying that "we have as yet no specific serum or other specific means for the cure of influenza." Quite true; but our present knowledge of two most important biologic laws, namely, the extraordinary variation under changing environments of certain species of bacteria, together with the even more marked morphologic changes in the same species under various abnormal conditions, should allow us to predict with a certain degree of accuracy the results of a given series of procedures. The identity of the influenza bacillus may fairly be assumed. The evidence
Influence of Atrial Fibrillation on Outcome Following Mitral Valve Repair
Authors: Eric Lim, Clifford W. Barlow, A. Reza Hosseinpour, Christopher Wisbey, Kate Wilson, Willis Pidgeon, Susan Charman, John B. Barlow, Francis C. Wells
Journal: Circulation (2001)

To investigate the outcome of patients in atrial fibrillation (AF) following mitral valve repair, clinical and echocardiographic follow-up was undertaken in 400 consecutive patients who underwent mitral valvuloplasty from 1987 to 1999.The main indications for surgery were degenerative (81.4%), endocarditis (7.1%), rheumatic (6.6%), ischemic (4.6%), and traumatic (0.3%) mitral valve disease. After excluding 6 paced patients and 1 patient in nodal rhythm, we compared the outcomes of 152 patients in AF against 241 patients in sinus rhythm. For patients in AF versus those in sinus rhythm, more AF patients were older (mean age 67.2+/-8.8 versus 61.9+/-11.8 years, respectively; P<0.001), more were assigned to a poorer New York Heart Association (NYHA) class (77.6% versus 66.0% in NYHA III/IV, respectively; P=0.01), and more demonstrated impaired ventricular function (78.9% versus 46.2% with moderate or severe impairment, respectively; P<0.001). For patients in AF versus those in sinus rhythm, there was no difference in 30-day mortality (2.0% versus 2.1%, respectively; P=0.95), repair failure (5.4% versus 3.6%, respectively; P=0.41), stroke (5.4% versus 2.2%, respectively; P=0.11), or endocarditis (2.3% versus 0.9%, respectively; P=0.27) on follow-up at a median of 2.8 years (interquartile range 1.1 to 6.0). On echocardiography, the proportion of patients with mild regurgitation or worse was 13.3% (AF patients) versus 10.8% (patients in sinus rhythm) (P=0.70). Patients in AF versus those in sinus rhythm had lower survival at 3 years (83% versus 93%, respectively) and 5 years (73% versus 88%, respectively). Univariate analysis identified factors affecting survival as AF (P=0.002), age >70 years (P=0.041), and poor ventricular function (P<0.001). However, by use of a multivariate model, only poor ventricular function remained significant (P=0.01).AF does not affect early outcome or durability of mitral repair. The onset of AF may be indicative of disease progression because of its association with poor left ventricular function.
Ligand-Modified Vesicular Stomatitis Virus Glycoprotein Displays a Temperature-Sensitive Intracellular Trafficking and Virus Assembly Phenotype
Authors: Ghiabe H Guibinga, Frederick L Hall, Erlinda M Gordon, Erkki Ruoslahti, Theodore Friedmann
Journal: Molecular Therapy (2003)

The production of potentially targetable VSV-G-pseudotyped retrovirus vectors has been hampered by inadequate understanding of the structure–function relationships of the VSV-G protein. In these studies we demonstrate assembly and production of MLV-based and HIV-1-based vector particles using VSV-G proteins modified by the insertion of a peptide ligand into a site corresponding to amino acid position 24 of the native VSV-G molecule. The inserted ligand represents the decapeptide encoding the collagen-binding domain of von Willebrand factor. We have used deconvolution microscopy to demonstrate that the modified VSV-G molecules sequester in perinuclear structures and are unavailable for assembly of infectious virus particles at the cell surface under standard tissue culture conditions at 37°C. In contrast, at a lower permissive temperature of 30°C, the modified VSV-G protein traffics appropriately to the cell surface and participates in useful titers. Furthermore, VSV-G-pseudotyped MLV-based and HIV-1-based vectors displaying the collagen-binding domain demonstrate a statistically significant increased attachment to a collagen matrix as indicated by an ELISA-like cell binding assay and by a focus transduction assay.
STAPHYLOCOCCUS LUGDUNENSIS: A RARE BUT DESTRUCTIVE CAUSE OF INFECTIVE ENDOCARDITIS WITH ECHOCARDIOGRAPHIC AND CLINICAL FEATURES SIMILAR TO STAPHYLOCCOCCUS AUREUS INFECTIVE ENDOCARDITIS
Authors: Marwa Sabe, Nabin Shrestha, Steven Gordon, Venu Menon
Journal: Journal of the American College of Cardiology (2012)
Milk as Obstipant
Authors: Thrift G. Hanks
Journal: JAMA (1974)

To  Editor.—  The absence of reference to cow's milk in Dietary Fiber and Disease (229:1068, 1974) is surprising in an article dealing with the amount of time necessary for  passage of intestinal content through  alimentary tract, and to  bulk and consistency of   Ingestion of cow's milk is a common cause of constipation in infants, teen-agers, and middle-aged adults, and of obstipation and fecal impaction in  elderly. Except where, uncommonly, milk ingestion is associated with diarrhea, it can increase  consistency of stools dramatically. In young women who returned to normal bowel habits by elimination of milk and addition of fruit and vegetable fiber to their diet, soft bulky stools and absence of constipation is readily achieved. On adding milk to  fiber regimen, constipation often returns, as does  appearance of dense, compacted stools. Among elderly persons, while obstipation may have multiple associations, many
Sudden Cardiac Death
Authors: M J Davies
Journal: BMJ (1994)

Mark E Josephson Blackwell Scientific, £69.50, pp 432 ISBN 0-86542-199-4

Descriptions of an elephant by observers permitted to examine only one aspect of the beast differ greatly. The same restraint applies to this book. The individual contributions are excellent reviews of some aspects of sudden death, but little attempt has been made to integrate them into an overall view.

The first sentence of the preface states that sudden death is the leading cause of death in the United States. It is in fact the leading mode of death; …
An Electrocardiographic Pattern Associated with Mitral Valve Deformity in Marfan's Syndrome
Authors: DORRANCE BOWERS
Journal: Circulation (1961)

A collected series of 5 patients with Marfan's syndrome is reported in whom S-T depression and T-wave inversion in electrocardiographic leads II, III, and aV F were associated with necropsy-proved deformity of the mitral valve.
Cross-Indexed File for Medical Literature
Authors: DUKE H. BAKER
Journal: Annals of Internal Medicine (1974)

Letters1 April 1974Cross-Indexed File for Medical LiteratureDUKE H. BAKER, M.D., RICHARD H. BRASHEAR, M.D.DUKE H. BAKER, M.D.Search for more papers by this author, RICHARD H. BRASHEAR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-4-557 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Jeghers (1) emphasized the importance of a personal filing system in self-education, and recently several papers concerning filing systems have been published (2-5).Our somewhat different method for filing and retrieving medical literature is designed to meet the individual needs of those physicians and paramedical personnel involved in self-education, patient care, teaching, and research. The system (Figure 1) is based on a personalized index that develops and expands in response to the growth and change of the user's interests. References (reprints, monographs, abstracts, and so forth) are listed under several topic categories, thus incorporating the dimension of...References1. JEGHERS H: Medical care, education and research. Philosophy and technics of self-education of the medical student and physician. N Engl J Med 271:1297-1301, 1964 CrossrefMedlineGoogle Scholar2. FULLER E: A system for filing medical literature. Based on a method developed by Dr. Maxwell M. Wintrobe. Ann Intern Med 68:684-693, 1968 LinkGoogle Scholar3. ALARCÓN RD: A personal medical reference index. Lancet 1:301-305, 1969 CrossrefMedlineGoogle Scholar4. ULTMANN J: More on duplicate abstracts and filing (letter). Ann Intern Med 68:710-712, 1968 LinkGoogle Scholar5. GAEKEGAEKE RM: Filing medical literature. A textbook-integrated system. Ann Intern Med 78:985-987, 1973 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Indiana University School of Medicine PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe electronic information revolution and how to exploit itThe Personal Information CenterTreatment of postoperative ureteral stricture by catheter dilation: A forgotten procedureA Literature Filing System for the Clinical PharmacistMechanical Sorting of AbstractsDAVID MILLS, M.D. 1 April 1974Volume 80, Issue 4Page: 557-559KeywordsAllied health care professionalsPatients Issue Published: 1 April 1974 PDF downloadLoading ...
Unexpected hepatotoxicity after priming and treatment with molgramostim (rhGM-CSF) in acute myeloid leukemia during induction chemotherapy
Authors: Per Boye Hansen, Hans E. Johnsen, Jens Otto Lund, Mogens Sandbjerg Hansen, Niels Ebbe Hansen
Journal: American Journal of Hematology (1995)

Abstract The effect of supplementing induction chemotherapy with recombinant human granulocyte‐macrophage colony‐stimulating factor (rhGM‐CSF) was studied in a randomized trial of 18 patients with acute myeloid leukemia (AML). Ten patients received rhGM‐CSF, starting on day one to three before chemotherapy and continued for a maximum of 21 days after the start of induction treatment. Unexpected adverse effects of rhGM‐CSF and chemotherapy combination included a transient decline in plasma coagulation factors II, VII, and X (5 of 5 patients) and an increased transcapillary escape rate of albumin (in 3 of 3 patients tested). The decline in coagulation factors was prevented in subsequent patients by prophylactic treatment with vitamin K. Although the small number of patients studied may not allow a definite conclusion, caution with regard to liver function should be shown in combining rhGM‐CSF with intensive chemotherapy. ©1995 Wiley‐Liss, Inc.
Increased dispersion of “refractoriness” in patients with idiopathic paroxysmal atrial fibrillation
Authors: Anand R. Ramdat Misier, Tobjas Opthof, Norbert M. van Hemel, Jo J.A.M. Defauw, Jacques M.T. de Bakker, Michiel J. Janse, Frans J.L. van Capelle
Journal: Journal of the American College of Cardiology (1992)
Interactive Medical Cases — A New<i>Journal</i>Feature
Authors: Graham T. McMahon, Caren G. Solomon, John J. Ross, Joseph Loscalzo, Edward W. Campion
Journal: New England Journal of Medicine (2009)

Educators have long recognized that learning is enhanced and retention improves when the educational material is relevant and engaging and includes interaction. Building on the increasing capacity of the online environment, we are pleased to launch this week a new series of Interactive Medical Cases at NEJM.org. The interactive cases are an extension of the Clinical Problem-Solving cases that we publish each month. These articles present clinical cases that are diagnostic puzzles. In the articles published in print, an expert clinician discussant responds to sequential clinical information as a case unfolds, eventually reaching a diagnosis. The interactive cases are designed . . .
On a Case of Gastrostomy: With Remarks on the Operation
Authors: T. F. Chavasse
Journal: BMJ (1884)

JO7REL l1mb.i electricity acts is to conserve the nerve-force, which is the strength of life, in the centres ; at the same time sensibly relievi -that most distressing feeling of exhaustion, which is, in itself, a fruitfl :eouree of mischief in .theemergency-by the mental depression it .poduces,and the consequent loss of.the aid of the cerebral centres in prolonging life.it is probably needless to point out that the patient :r,n be fed with a wooden spoon or porcelain feeder, ordinary care meing taken not to make contact, by any conductor, with the ground.Obviously, this suggestion only rates to an adjunct to the treatment of fever, in an emergency which arises in no small proportion of cases, and which is most embarassng to the practitioner, as well as perilous to the patient It is, hoWever, of nore than sufficient promise to war- rant a triaL
Temporal arteritis--dysphagia and a normal ESR
Authors: P. Watson
Journal: JAMA (1984)

To the Editor.—  Temporal arteritis (TA) may be seen in unusual ways.1,2This patient's case is reported because of its singular nature, particularly the prominent dysphagia. Earlier treatment might have prevented the subsequent tragic visual loss.  Report of a Case.—  A 66-year-old woman sustained blindness in the left eye four days before to admission. On admission, she had the funduscopic findings of central retinal artery occlusion on the left. She had not suffered headache, myalgia, weight loss, fever, malaise, or jaw claudication. Her only other complaint was discomfort on swallowing of two weeks' duration, to such a degree that she took only tepid fluids. The superficial temporal artery was nontender and weakly palpable bilaterally. Her ESR (Westergren) was 18 and 4 mm/hr on separate occasions, measured within an hour of the blood sample being taken. She was not anemic. On the second hospital day she complained of transient obscuration
Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function
Authors: Isabelle Dunand-Sauthier, Marie-Laure Santiago-Raber, Leonardo Capponi, Charles E. Vejnar, Olivier Schaad, Magali Irla, Queralt Seguín-Estévez, Patrick Descombes, Evgeny M. Zdobnov, Hans Acha-Orbea, Walter Reith
Journal: Blood (2011)
Review of social service organisation needed?
Authors: J. R Cypher
Journal: BMJ (1980)

Nor do I agree with him that money, fame, and power are the usual motives behind such forgeries.There is, however, a long tradition among scientists of faking results in order to establish a pet theory, and those like Cyril Burt who have followed it include Haekel, Mendel, Kammering, Blondlot, Dubois, and (I believe) Teilhard de Chardin.To my mind, Malcolm Bowden's book Ape Man: Fact or Fallacy ?4 has irrevocably implicated Teilhard not only in the Piltdown forgery, but also in manufacturing evidence concerning Pekin and Java Man.Teilhard's motive was to establish the rather potty theory of evolution spelled out in "The Phenomenon of Man."The esteem that this book was held in and his own continuing high reputation must make him a candidate for the title of "Faker of the Century.
Microalbuminuria: associations with height and sex in non-diabetic subjects.
Authors: M M Gould, V Mohamed-Ali, S A Goubet, J S Yudkin, A P Haines
Journal: BMJ (1993)

OBJECTIVES--To study the association(s) between microalbuminuria and cardiovascular risk factors in non-diabetic subjects. DESIGN--Patients aged 40-75 years were randomly selected from a general practice list and invited to participate. SETTING--Health centre in inner city London. SUBJECTS--Of those invited, 1046 out of 1671 (62.6%) attended. Subjects were excluded for the following reasons: not being white (44); urinary albumin excretion rate &gt; 200 micrograms/min (3); having a urinary infection (5); taking penicillamine or angiotensin converting enzyme inhibitors (7); older than 75 (2); having diabetes (25); missing data on glucose concentration (1). MAIN OUTCOME MEASURES--Glucose tolerance test results, albumin excretion rate from overnight and timed morning collections of urine; blood pressure; height. RESULTS--Mean albumin excretion rate was significantly lower in women than men (mean ratio 0.8, 95% confidence interval (0.69 to 0.91)). Mean albumin excretion rate was significantly associated with age, blood pressure, and blood glucose concentration (fasting, 1 hour, and 2 hour) in men and inversely with height. Men who had microalbuminuria in both samples were significantly shorter (by 5 cm (1.3 to 9.3 cm)) than those who had no microalbuminuria in either sample when age was taken into account. In the case of women only systolic pressure was significantly associated with albumin excretion rate. CONCLUSIONS--Microalbuminuria and short stature in men are associated. Cardiovascular risk has been associated with both of these factors and with lower birth weight. The inverse association of microalbuminuria with height is compatible with the suggestion that factors operating in utero or early childhood are implicated in cardiovascular disease. The higher prevalence of microalbuminuria in men compared with women may indicate that sex differences in cardiovascular risk are reflected in differences in albumin excretion rate.
Pulmonary emboli in young adults.
Authors: C. A. Loehry
Journal: BMJ (1966)

Case histories were examined of all in-patients at St. Thomas Hospital (London) 1954-1964 who were diagnosed as pulmonary emboli and who were under the age of 40.  In 62 of 94 cases examined additional features were present which predisposed the individual to thromboembolic disease.  The remaining 32 cases were idiopathic.  None of the female patients had been taking oral contraceptives and it is suggested that reports linking thromboembolic disease to oral contraceptives may simply reflect the increased incidence of this disease among young people.(AUTHORS MODIFIED)
Salty and Bitter Taste
Authors: Thomas Trannel
Journal: JAMA (1991)

<h3>To the Editor.</h3> —Regarding Dr Henkin's discussion of phantogeusia,<sup>1</sup>we recently evaluated 17 consecutive patients presenting to the Smell &amp; Taste Treatment and Research Foundation with this chemosensory complaint. All patients underwent extensive chemosensory testing, neurologic and psychiatric examinations, and psychological testing including the Minnesota Multiphasic Personality Inventory type II, the Millon Clinical Multiaxial Inventory type II, and the Beck Depression Inventory. Whereas Henkin described anxiety and depression in idiopathic phantogeusia, we found no indication of depression in this group with average Beck scores of 8.5. The complaint of phantogeusia did suggest, however, that the<i>Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised</i>classification of generalized anxiety disorder was present. Since γ-aminobutyric acid (GABA) abnormality exists in generalized anxiety disorder,<sup>3</sup>it is possible that a common pathogenic mechanism causes both states. Therefore, we recommend adding clonazepam to the suggested treatments of this condition, which, in our
Maternal Death from Pre-eclampsia: Post-mortem Caesarean Section
Authors: L. J. German
Journal: BMJ (1962)

MBJouRNA identical with that causing human cutaneous leish- maniasis in British Honduras-namely, L. brasiliensis mexicana.The joint presence of these infected animals and infected Phlebotomus species in an area where numerous persons have developed cutaneous leishmaniasis clearly indicates that the disease in British Honduras is a zoonosis, with the rodent population acting as a reservoir of infection for man.This would account for the restriction of " bay-sore " or " chiclero's ulcer " to those people who spend much of their time in densely forested regions.The epidemiology of the disease is likely to prove the same in the neighbouring countries of Mexico, Guatemala, and Honduras.A more detailed account of these studies is in preparation.
High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure
Authors: Keiko Maeda, Takayoshi Tsutamoto, Atsuyuki Wada, Naoko Mabuchi, Masaru Hayashi, Takashi Tsutsui, Masato Ohnishi, Masahide Sawaki, Masanori Fujii, Takehiro Matsumoto, Masahiko Kinoshita
Journal: Journal of the American College of Cardiology (2000)
Interrelationships of Hyperinsulinism and Hypertriglyceridemia in Young Patients with Coronary Heart Disease
Authors: MANUEL TZAGOURNIS, ROSS CHILES, JOSEPH M. RYAN, THOMAS G. SKILLMAN
Journal: Circulation (1968)

Fasting serum lipid levels, glucose tolerance, and immunoreactive insulin concentrations of 50 young patients with coronary heart disease (CHD) and 30 control subjects were evaluated to study the interrelationships of these metabolic factors. Abnormalities in one or more of these factors could be shown in 90% of the patients and 20% of the control subjects. Thirty-four of the 50 patients had elevated cholesterol or triglyceride levels, or both, 30 had abnormally elevated or delayed insulin responses after glucose, and 17 had abnormal glucose tolerance. A significant correlation existed between serum triglyceride and insulin concentrations. When insulin levels were reduced by phenformin, triglyceride concentrations fell toward normal. These findings indicate that carbohydrate, insulin, and lipid abnormalities are rather prevalent in patients with CHD. Excessive insulin secretion secondary to mild glucose intolerance probably induces hepatic synthesis of triglycerides and hypertriglyceridemia. Dietary alterations or pharmacological agents may help to control some of the metabolic abnormalities associated with premature CHD.