Serum Thyrotropin and the Assessment of Thyroid Status
Authors: David A. Ehrmann
Journal: Annals of Internal Medicine (1989)

Editorials1 February 1989Serum Thyrotropin and the Assessment of Thyroid StatusDavid A. Ehrmann, MD, David H. Sarne, MDDavid A. Ehrmann, MDSearch for more papers by this author, David H. Sarne, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-3-179 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince their relatively recent introduction into clinical practice, sensitive immunoassays for serum thyrotropin have enhanced the ability of clinicians to firmly establish diagnoses which were once difficult or impossible to confirm with conventional thyrotropin assays. Despite the excellent ability of the latter to identify patients with primary hypothyroidism, their ability to differentiate euthyroid from hyperthyroid patients was limited because of assay insensitivity. Immunometric assays for thyrotropin differ from the conventional radioimmunoassay; rather than labeling the antigen component of the antigen-antibody complex, two separate monoclonal antibodies, each directed at a different epitope of the thyrotropin molecule, are used. This two-site or...References1. SethKellettCaldwell JHG. A sensitive immunoradiometric assay for serum thyroid stimulating hormone: a replacement for the thyrotrophin releasing hormone test? Br Med J. 1984;289:1334-6. CrossrefMedlineGoogle Scholar2. McBrideThibeaultRodgerson JRD. Thyrotropin as measured by a sensitive immunoradiometric assay. Clin Chem. 1985;31:1865-7. CrossrefMedlineGoogle Scholar3. MartinoBambiniBartalena EGL. Human serum thyrotrophin measurement by ultrasensitive immunoradiometric assay as a first-line test in the evaluation of thyroid function. Clin Endocrinol (Oxf). 1986;24:141-8. CrossrefMedlineGoogle Scholar4. HennesseyEvaulTsengBurmanWartofsky JJVKL. 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Google Scholar19. KahnWeintraubCsakoZweig BBGM. Factitious elevation of thyrotropin in a new ultrasensitive assay: implications for the use of monoclonal antibodies in "sandwich" immunoassay. J Clin Endocrinol Metab. 1988;66:526-33. CrossrefMedlineGoogle Scholar20. GowKellettSethSweetingToftBeckett SHJVAG. Limitations of new thyroid function tests in pregnancy. Clin Chim Acta. 1985;152:325-33. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: David A. Ehrmann, MD; David H. Sarne, MDAffiliations: University of Illinois at Chicago Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInvestigationsCanine thyrotropin β-subunit gene: cloning and expression in Escherichia coli, generation of monoclonal antibodies, and transient expression in the Chinese hamster ovary cellscDNA cloning of canine common α gene and its co-expression with canine thyrotropin β gene in baculovirus expression system☆Ultrasonographic and Doppler Study of the Thyroid Gland in Graves’ Disease Before and After Treatment with Antithyroid DrugsULTRASONOGRAPHIC AND DOPPLER STUDY OF THE THYROID GLAND IN GRAVES' DISEASE BEFORE AND AFTER TREATMENT WITH ANTITHYROID DRUGSAdvances in thyroid orbitopathyEffects of subclinical hyperthyroidism on renal handling of water and electrolytes in patients with nodular goiterEffective laboratory Evaluation of Thyroid StatusSudden death associated with undiagnosed Graves' diseaseAnalytical and clinical performance of six sensitive thyrotrophin kits 1 February 1989Volume 110, Issue 3Page: 179-181KeywordsAntigensHypothyroidismImmunoassaysInterleukinsMonoclonal antibodiesRadioimmunoassaysThyroidThyroid-stimulating hormone ePublished: 1 December 2008 Issue Published: 1 February 1989 Copyright & Permissions© 1989 American College of PhysiciansPDF downloadLoading ...