tbuckley/cabot-search huggingface dataset:
Action of novel CD37 antibodies on chronic lymphocytic leukemia cells
Authors: G Krause, M Patz, P Isaeva, M Wigger, I Baki, V Vondey, S Kerwien, M Kuckertz, R Brinker, J Claasen, L P Frenzel, C-M Wendtner, K-H Heider, M Hallek
Journal: Leukemia (2011)
Ticagrelor Increases Adenosine Plasma Concentration in Patients With an Acute Coronary Syndrome
Authors: Laurent Bonello, Marc Laine, Nathalie Kipson, Julien Mancini, Olfa Helal, Julien Fromonot, Vlad Gariboldi, Jocelyne Condo, Franck Thuny, Corinne Frere, Laurence Camoin-Jau, Franck Paganelli, Françoise Dignat-George, Regis Guieu
Journal: Journal of the American College of Cardiology (2013)
THE SCOPE OF CAESAREAN SECTION: AN ANALYSIS OF 295 CASES OF THE CLASSICAL OPERATION
Authors: F. Ivens
Journal: BMJ (1928)

h2 D~.-2tTw S4?S L CASARHI 8gOWIOQ.urge the value of the cardiac.sigl " in these cases, and of the necessity for the search for " occult blood," and forx-r.ay investigation.(;G.tiie or Duodenal Ulcer or their Sefitels.-Apartfrom the unicommoni cases in which cancer supervenes in ulcer, theree is usually less difficulty here than with chronic gastriti §; for canlcer is rare at the earlier ages wheis ulcer is imost common.The duration of ulcer is often much loliger than that of canicer, and the symptoms,tend to lisoappear and to rec ur.Paini in ulcer is usually more seVere thail in catncer, but lcss coiitinuous, more aggravated by food, more relieved by vomiting.Al)etite in ulcer generally remains good, although the patieiit may refrain froai catinig for fear of causinig pain.Tenderness dver the
Nonadherent: A Four-Letter Word
Authors: Erin N. Wilmer
Journal: Annals of Internal Medicine (2013)

On Being a Doctor5 February 2013Nonadherent: A Four-Letter WordErin N. Wilmer, BSErin N. Wilmer, BSFrom University of Florida College of Medicine, Gainesville, Florida.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-3-201302050-00016 Audio Reading - “Nonadherent: A Four-Letter Word” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Nonadherent: A Four-Letter Word," by E.N. Wilmer. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Do you have any idea how frustrating you were? You refused to take certain medications; contested every blood draw; limited all your responses to “yes,” “no,” or “I don't know.” Nonadherence in the form of missed dialysis appointments was the reason that you were admitted to the hospital in the first place. Don't you realize that? Why do you refuse to take care of yourself? Do you not trust us? Do you not care?And who was that strange man who delivered a “package” to your room and told you that next time you have to pay for the gas ... Author, Article, and Disclosure InformationAffiliations: From University of Florida College of Medicine, Gainesville, Florida.Corresponding Author: Erin N. Wilmer, BS, University of Florida College of Medicine, PO Box 101375, Gainesville, FL 32610; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Nonadherent: A Four-Letter Word” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Nonadherent: A Four-Letter Word," by E.N. Wilmer. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 5 February 2013Volume 158, Issue 3Page: 217KeywordsAntiretroviral therapyBirthBloodCocaineDrugsForecastingHeartMedical dialysisPharynxSuicide ePublished: 5 February 2013 Issue Published: 5 February 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Conquering rheumatoid arthritis. The latest breakthroughs and treatments: Thomas Lee. (Pp 250, $20.) Amherst, New York: Prometheus Books, 2001. ISBN 1-57392-886-0
Authors: E M Veys
Journal: Annals of the Rheumatic Diseases (2002)

Guidelines for the treatment of osteoarthritisGuidelines for the treatment of osteoarthritis (OA) have several purposes, but a major one relates to its use by regulatory or medical insurance agencies that use it to help guide their response to requests for drugs to treat patients.Data have recently been published which record the efficacy of non-steroidal antiinflammatory drugs (NSAIDs) over paracetamol (acetaminophen) and report patients' preferences for NSAIDs rather than paracetamol in the treatment of OA. [1][2][3][4][5][6][7] Furthermore, inflammation is a common accompaniment of moderate to severe OA. [8][9][10] Therefore it would seem appropriate to consider the use of NSAIDs as the primary treatment in the group of patients with OA with moderate to severe pain or inflammation as part of their disease.The EULAR Guidelines state that paracetamol is the first line of treatment for all patients with OA, 11 despite the recent evidence that NSAIDs are more efficacious than paracetamol and that paracetamol is associated with more gastrointestinal toxicity than was previously thought. 12ould it not be more appropriate to suggest that patients who have moderate to severe pain and/or OA with inflammatory components be given NSAIDs as the first line of treatment, leaving paracetamol for symptomatic use in those patients with lesser degrees of pain or lack of overt inflammation?
Letter: "Caecal squelch" and appendicitis.
Authors: B V Palmer
Journal: BMJ (1975)

The very fit man had the highest rise, from 0 9 to 10 9 ,ug/I.In contrast, the level in the older Greek runner remained virtually un- changed (0-8 and 1-0 ,g/l).Our investigation confirms the significant rise of plasma GH previously reported after physical exercise.'-3This work is one of a series of studies on the effects of physical exercise on plasma hormones and muscular metabolism.We hope to find tests to distinguish in advance between men who are fit enough to run the marathon and those for whom it may be dangerous.4That such tests may be necessary has already been demonstrated by the case of Philippides, the dispatch-runner who died on arrival at Athens after the Battle of Marathon on 22 September 490 BC.
Cutaneous type of adult T cell leukemia/lymphoma in a French West Indian woman
Authors: Antoine Gessain, Isabelle Moulonguet, Béatrice Flageul, Pascal Perrin, Catherine Capesius, Marie-Françoise D’Agay, Christian Gisselbrecht, François Sigaux, Jean Civatte
Journal: Journal of the American Academy of Dermatology (1990)
Effectiveness of anonymised information sharing and use in health service, police, and local government partnership for preventing violence related injury: experimental study and time series analysis
Authors: C. Florence, J. Shepherd, I. Brennan, T. Simon
Journal: BMJ (2011)

<b>Objective</b> To evaluate the effectiveness of anonymised information sharing to prevent injury related to violence. <b>Design</b> Experimental study and time series analysis of a prototype community partnership between the health service, police, and local government partners designed to prevent violence. <b>Setting</b> Cardiff, Wales, and 14 comparison cities designated "most similar" by the Home Office in England and Wales. <b>Intervention</b> After a 33 month development period, anonymised data relevant to violence prevention (precise violence location, time, days, and weapons) from patients attending emergency departments in Cardiff and reporting injury from violence were shared over 51 months with police and local authority partners and used to target resources for violence prevention. <b>Main outcome measures</b> Health service records of hospital admissions related to violence and police records of woundings and less serious assaults in Cardiff and other cities after adjustment for potential confounders. <b>Results</b> Information sharing and use were associated with a substantial and significant reduction in hospital admissions related to violence. In the intervention city (Cardiff) rates fell from seven to five a month per 100 000 population compared with an increase from five to eight in comparison cities (adjusted incidence rate ratio 0.58, 95% confidence interval 0.49 to 0.69). Average rate of woundings recorded by the police changed from 54 to 82 a month per 100 000 population in Cardiff compared with an increase from 54 to 114 in comparison cities (adjusted incidence rate ratio 0.68, 0.61 to 0.75). There was a significant increase in less serious assaults recorded by the police, from 15 to 20 a month per 100 000 population in Cardiff compared with a decrease from 42 to 33 in comparison cities (adjusted incidence rate ratio 1.38, 1.13 to 1.70). <b>Conclusion</b> An information sharing partnership between health services, police, and local government in Cardiff, Wales, altered policing and other strategies to prevent violence based on information collected from patients treated in emergency departments after injury sustained in violence. This intervention led to a significant reduction in violent injury and was associated with an increase in police recording of minor assaults in Cardiff compared with similar cities in England and Wales where this intervention was not implemented.
Selection of Valves for TAVR
Authors: E. Murat Tuzcu, Samir R. Kapadia
Journal: JAMA (2014)

Transcatheter aortic valve replacement (TAVR) was first performed in 2002.1 Since then, a tremendous amount of progress with this innovative technology has resulted in widespread adoption of this procedure for treatment of aortic valve disease. More than 10 000 TAVRs were performed in the United States alone since Food and Drug Administration (FDA) approval of the first device in 2011.2 Contrary to Europe, where 10 different valves have been approved by the European Union, in the United States all except a few hundred cases have been performed using only 2 valves. These 2 distinctly different transcatheter valve systems have gone through a series of developments. However, the fundamental characteristics of the valves remain unchanged.
Suicidal Compromises: Psychopathy and Rehabilitation
Authors: H. Wilson
Journal: BMJ (1942)

DELAY IN UNION OF FRACTURES MICAL JOURNAL9the femur in children treated by suspension, where complete immobilization is impossible.The following are typical examples of seventeen patients treated adequately in non-padded plaster cases for fracture of the tibia and fibula.These reports illustrate the slowness of union which is so often caused by this form of treatment, and suggest a simple method by which union may be hastened.Cases of Slow Union in Non-padded Plaster Case 1.-This patient, a sergeant, had a fracture of the tibia and fibula in the lower third of the leg, treated by fixation in a non-padded plaster, which included the knee-joint.Reduction gave little trouble, as the fracture line was almost transverse, and the patient walked in the cast after two weeks' recumbency.After the third cast had been removed twenty-two weeks later there was no clinical or x-ray sign of union, movement being free at the site of fracture.The x-ray photographs showed almost perfect apposition of the fractured surfaces without sclerosis of the bone ends and with a slight degree of decakification.A calliper splint and a cloth boot were applied, and in this apparatus the patient walked about freely and without pain.After eight weeks, union was complete clinically and almost complete radiologically.Case 2.-Fracture of both bones in the same region; reduction was excellent, and a non-padded plaster cast was applied.In this the patient walked continuously, starting three weeks after its application; but on removal of the second cast eighteen weeks later the conditions present were almost identical with those of the first patient.A calliper splint and a cloth boot were applied, and in nine weeks union was complete both clinically and radiologically.Case 3.-A gunner aged 27 had a simple fracture of both bones of the leg-fracture long transverse-reduced and put in non-padded plaster.Eighteen weeks later, when the second plaster was removed, non-union was apparent.Radiographs showed perfect apposition, no sclerosis of the bone ends, and no sign of new callus formation.A calliper splint and a cloth
Skin Immunoglobulins in Systemic Lupus Erythematosus.
Authors: John S. Percy
Journal: Annals of Internal Medicine (1968)

s1 May 1968Skin Immunoglobulins in Systemic Lupus Erythematosus.John S. Percy, M.D., Charley J. Smyth, M.D., F.A.C.P.John S. Percy, M.D.Search for more papers by this author, Charley J. Smyth, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1141_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn order to establish the diagnostic specificity of gamma globulin deposition at the dermal-epidermal interface in the clinically normal skin in systemic lupus erythematosus (SLE), 150 skin biopsies have been studied using immunofluorescent techniques.The biopsies investigated were from patients with SLE, rheumatoid arthritis, other connective tissue diseases, glomerulonephritis, and malignant diseases as well as from clinically normal persons. Cryostat sections of skin samples obtained by punch biopsy were stained for globulin using a fluorescein-conjugated anti-human globulin preparation. Wherever possible, the globulins present were identified using specific antisera, and in these cases the immunoglobulin type of the antinuclear factor was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1141-1141KeywordsBiopsyConnective tissue diseasesGlobulinsGlomerulonephritisLupus erythematosusRheumatoid arthritisSpecificity Issue Published: 1 May 1968 PDF DownloadLoading ...
Approval given for trials of AIDS vaccine
Authors: D. Josefson
Journal: BMJ (1998)

The Food and Drug Administration in the United States has approved final phase clinical trials for the world's first AIDS vaccine.

The vaccine, known as AIDSVAX, is based on gp120, an HIV envelope glycoprotein that interacts with and binds to T cell surface receptors. It is manufactured by VaxGen, a subsidiary of Genentech.

The vaccine will be tested on 5000 US volunteers who have tested negative for HIV but are at high risk of contracting AIDS through sexual contact, and on 2500 volunteers from Thailand who are injecting drug users. These …
Decreased first-pass metabolism of labetalol in chronic liver disease.
Authors: M Homeida, L Jackson, C J Roberts
Journal: BMJ (1978)

The effect of chronic liver disease on the rate of elimination and extent of "first-pass" metabolism of labetalol was studied. Pharmacokinetic measurements were made after both oral and intravenous administration to seven healthy subjects and to 10 patients with chronic liver disease. Plasma half life was similar in the two groups. Plasma concentrations were considerably higher in the patients than in the healthy subjects after oral administration but similar after intravenous injection. Thus the bioavailability of labetalol was increased in liver disease due to reduced first-pass metabolism. Bioavailability in the group of patients correlated negatively with serum albumin concentration. There were falls in supine heart rate and blood pressure which tended to be greater after oral administration in the patients with liver disease, suggesting an exaggerated response related to the increased bioavailability. Oral dosage requirements of labetalol and possibly other drugs susceptible to first-pass metabolism are reduced in the presence of liver disease.
A man with intermittent fever and arthralgia
Authors: S. M Knight, D. P M Symmons
Journal: Annals of the Rheumatic Diseases (1998)

Case reportA 44 year old, previously healthy, white man, who was a milk depot manager, was referred to a general physician in November 1991 with a 16 month history of febrile episodes, lasting for three or four days, which recurred approximately every six weeks.During the episodes his temperature rose to 40°C, he felt flu-like and had aching limbs and profuse night sweats.He had no other symptoms of note and in particular no rash, no weight loss, no joint swelling, and no gastrointestinal or genitourinary symptoms.There was a family history of thyroid disease.He smoked 15-20 cigarettes a day.He had been on holiday to Tunisia in 1987, the Greek islands in 1990 and Portugal in 1991.He weighed 81.2 kg.No abnormalities were found on examination.Initial investigations focused on screening for infection.Full blood count, erythrocyte sedimentation rate, renal function, liver function, thyroid function, chest radiography, and computed tomography of the abdomen were normal.Blood cultures were negative, as were a Mantoux test and early morning urine analysis for tuberculosis.He also had negative serology for syphilis, brucella, toxoplasma, and leptospirosis.In May 1992 the febrile episodes became more frequent and he was referred for a second opinion to an infectious diseases unit.The differential diagnosis included an occult infection and a connective disease.An infection screen was again negative.Rheumatoid factor, antinucleur antibodies, and ds-DNA antibodies were negative and immunoglobulin concentrations were normal.It was suggested that he might have adult onset Still's disease.
Randomised controlled trials with full factorial designs
Authors: P. Sedgwick
Journal: BMJ (2012)

Researchers explored the effectiveness of three interventions in preventing falls among older people. The three interventions were group based exercise, home hazard management, and vision improvement. A randomised controlled trial with a full factorial design was used. The control treatment was no intervention. The study design allowed the effectiveness of each intervention to be evaluated plus exploration of their effects when combined. The researchers recruited 442 participants aged 70 years and over living at home in an urban community in Melbourne, Australia. The main outcome measure was self reported time to first fall after randomisation.1 The researchers reported that group based exercise was the most effective single intervention in reducing the number of falls. Falls were further reduced by the addition of home hazard management or vision management, or both. How many treatment groups were there in the above randomised controlled trial that incorporated a full factorial design?
EFFECTS OF SHORT-TERM EPITHELIAL RETICULAR CELL AND WHOLE ORGAN THYMUS GRAFTS IN NEONATALLY THYMECTOMIZED MICE
Authors: Esther F. Hays, Paul F. Alpert
Journal: The Journal of Experimental Medicine (1969)

Neonatally thymectomized mice were implanted with thymus grafts composed of epithelial reticular cells for periods of 7 and 14 days. Regardless of whether the grafts were placed immediately after thymectomy, or at 3 wk of age, there was little recovery of the lymphocyte depletion and impaired immunologic responsiveness, characteristically found in a neonatally thymectomized host. The findings were similar in animals studied at 2 months or 2 wk after graft removal. Many of the short-term remnant grafts were populated with lymphocytes and had attained the morphologic appearance of thymus by 14 days. A lesser degree of lymphocyte depletion and impaired responsiveness to SRBC occurred if thymectomy was delayed until 7 days of age, if remnant grafts were removed after 2 months, and if intact neonatal thymus was used for the short-term grafts. Complete normality was found in some of the animals in all of these groups. These observations suggest a direct role for mature thymus lymphocytes in reconstituting the neonatally thymectomized host and indicate that epithelial cell function is to direct the maturation of cells that ultimately behave as thymus lymphocytes.
Three quarters of guideline panellists have ties to the drug industry
Authors: I. Torjesen
Journal: BMJ (2013)

Two sisters developed gastrointestinal malabsorption with pain and unsteady gait due to polyneuropathy at age 15. Both had ophthalmoplegia, neurogenic EMG, and COX-negative muscle fibers. One patient had low muscle complex I–IV activity, multiple mtDNA deletions, and depletion, but no thymidine phosphorylase (TP) or dNT-2 gene mutations. TP activity and brain MRI were normal. The condition resembles mitochondrial neurogastrointestinal encephalomyopathy, except for the absence of leukoencephalopathy, and is likely caused by a nuclear DNA mutation that disrupts intergenomic signaling.
Low prevalence of antibodies to hepatitis C virus (HCV) as assessed by a second generation assay in community-acquired acute non-A, non-B hepatitis (CA-NANBH)
Authors: N. Tassopoulos, A. Hatzakis, V. Miriagou, I. Delladetsima, M. Koutelou, J. Chrispeels, H. Troonen
Journal: Journal of Hepatology (1991)