Polycystic Kidney Disease and Angiotensin-converting Enzyme Inhibitors
Authors: Michael Bursztyn
Journal: Annals of Internal Medicine (1992)

Letters1 July 1992Polycystic Kidney Disease and Angiotensin-converting Enzyme InhibitorsMichael Bursztyn, MDMichael Bursztyn, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-1-90_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Chapman and colleagues (1) described a situation where renal ischemia may bring about reversible acute renal failure when challenged with angiotensin-converting enzyme (ACE) inhibitors—the case of autosomal-dominant polycystic kidney disease (ADPKD) with massive cystic involvement, mostly concomitant with diuretic treatment. Over the years, I have treated with ACE inhibitors several ADPKD patients with mild renal insufficiency and hypertension who did not show such untoward effects; I wonder how frequently Chapman and coworkers encountered this complication. This finding is important in determining the relative risk for such a complication. Are Chapman and colleagues suggesting that we should refrain...References1. ChapmanGahowSchrier APR. Reversible renal failure associated with angiotensin-converting enzyme inhibitors in polycystic kidney disease. Ann Intern Med. 1991;115:769-73. LinkGoogle Scholar2. ChapmanJohnsonGahowSchrier AAPR. The renin-angiotensin-aldoesterone system and autosomal dominant polycystic kidney disease. N Engl J Med. 1990;323:1091-6. CrossrefMedlineGoogle Scholar1. ChapmanGabowSchrier APR. Reversible renal failure associated with angiotensin-converting enzyme inhibitors in polycystic kidney disease. Ann Intern Med. 1991;115:769-73. LinkGoogle Scholar2. Hollenberg N. Medical therapy of renovascular hypertension: efficacy and safety of captopril in 269 patients. Cardiovasc Rev Rep. 1983;4:852-76. Google Scholar3. WaeberSchallerWautersBrunner BMJH. Deterioration of renal function in hypertensive patient with scleroderma despite blood pressure normalization with Captopril. Klin Wochenschr. 1984;62:728-30. CrossrefMedlineGoogle Scholar4. ChapmanJohnsonGabowSchrier AAPR. The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease. N Engl J Med. 1990;323:1091-6. CrossrefMedlineGoogle Scholar5. WatsonMacnicolAllanWright MAPA. Effects of angiotensin converting enzyme inhibition in adult polycystic kidney disease. Kidney Int. 1992;41:206-10. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hadassah University Hospital Jerusalem 91240, Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMechanisms and management of hypertension in autosomal dominant polycystic kidney diseaseAntihypertensive drugs 1 July 1992Volume 117, Issue 1Page: 90-90KeywordsACE inhibitorsAcute renal failureAngiotensin converting enzymeAngiotensin converting enzyme inhibitorDiureticsHypertensionPolycystic kidney diseaseRelative riskRenal ischemia Issue Published: 1 July 1992 PDF DownloadLoading ...