Long-Delayed Localization of a Cardiac Functional Paraganglioma With<i>SDHC</i>Mutation
Authors: Frederic Illouz, Frederic Pinaud, Jean-Louis De Brux, Patrice Rodien, Delphine Mirebeau-Prunier
Journal: Annals of Internal Medicine (2012)

Letters7 August 2012Long-Delayed Localization of a Cardiac Functional Paraganglioma With SDHC MutationFrederic Illouz, MD, Frederic Pinaud, MD, Jean-Louis De Brux, MD, Delphine Mirebeau-Prunier, and Patrice Rodien, PhDFrederic Illouz, MDFrom CHU Angers, 49933 Angers Cedex 09, France; and Université Angers, 49933 Angers Cedex 09, France.Search for more papers by this author, Frederic Pinaud, MDFrom CHU Angers, 49933 Angers Cedex 09, France; and Université Angers, 49933 Angers Cedex 09, France.Search for more papers by this author, Jean-Louis De Brux, MDFrom CHU Angers, 49933 Angers Cedex 09, France; and Université Angers, 49933 Angers Cedex 09, France.Search for more papers by this author, Delphine Mirebeau-PrunierFrom CHU Angers, 49933 Angers Cedex 09, France; and Université Angers, 49933 Angers Cedex 09, France.Search for more papers by this author, and Patrice Rodien, PhDFrom CHU Angers, 49933 Angers Cedex 09, France; and Université Angers, 49933 Angers Cedex 09, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-3-201208070-00026 SectionsSupplemental MaterialAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This article has been corrected. The original version (PDF) is appended to this article as a supplement.Background: Paragangliomas and pheochromocytomas are rare tumors that can be located in the head, neck, thorax, or abdomen. Only a few cardiac paragangliomas have been reported.Objective: To describe what we believe to be the first cardiac paraganglioma in a patient with mutation of subunit C of the succinate dehydrogenase gene (SDHC).Case Report: In 1984, physicians admitted a 32-year-old man with paroxysmal hypertension (220/130 mm Hg) with headaches. He had a medical history of occlusion of a left retinal vein in 1971 ...References1. Opocher G, Schiavi F. Genetics of pheochromocytomas and paragangliomas. Best Pract Res Clin Endocrinol Metab. 2010;24:943-56. [PMID: 21115163] CrossrefMedlineGoogle Scholar2. Erickson D, Kudva YC, Ebersold MJ, Thompson GB, Grant CS, van Heerden JA, et al. Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab. 2001;86:5210-6. [PMID: 11701678] CrossrefMedlineGoogle Scholar3. Gupta N, Karwande S, Gupta S. Primary cardiac pheochromocytoma. J Am Coll Cardiol. 2009;53:732. [PMID: 19232909] CrossrefMedlineGoogle Scholar4. Schiavi F, Boedeker CC, Bausch B, Peçzkowska M, Gomez CF, Strassburg T, et al; European-American Paraganglioma Study Group. Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene. JAMA. 2005;294:2057-63. [PMID: 16249420] CrossrefMedlineGoogle Scholar5. Burnichon N, Rohmer V, Amar L, Herman P, Leboulleux S, Darrouzet V, et al; PGL. NET network. The succinate dehydrogenase genetic testing in a large prospective series of patients with paragangliomas. J Clin Endocrinol Metab. 2009;94:2817-27. [PMID: 19454582] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From CHU Angers, 49933 Angers Cedex 09, France; and Université Angers, 49933 Angers Cedex 09, France.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCorrection: Long-Delayed Localization of a Cardiac Functional Paraganglioma With SDHC Mutation Metrics Cited ByComprehensive review of evaluation and management of cardiac paragangliomasSuccinate Dehydrogenase Gene Mutations in Cardiac ParagangliomasCardiac ParagangliomasSDHC Mutations are Associated with Cardiac Paragangliomas: A Case Report of a Patient With a Dopamine-Secreting Tumor and Review of the LiteratureThe Clinical Phenotype of SDHC -Associated Hereditary Paraganglioma Syndrome (PGL3)Correction: Long-Delayed Localization of a Cardiac Functional Paraganglioma With SDHC Mutation 7 August 2012Volume 157, Issue 3Page: 222-223KeywordsComputed axial tomographyGenetic testingGermline mutationHead and neck tumorsHypertensionMagnetic resonance imagingPheochromocytomaPositron emission tomographyThoraxVeins ePublished: 7 August 2012 Issue Published: 7 August 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...