tbuckley/cabot-search huggingface dataset:
Studies on the Mechanism of Action of Insulin in Alloxan-diabetic Rats.
Authors: Alfred Gellhorn
Journal: Annals of Internal Medicine (1965)

s1 May 1965Studies on the Mechanism of Action of Insulin in Alloxan-diabetic Rats.Alfred Gellhorn, M.D., F.A.C.P., William Benjamin, M.D.Alfred Gellhorn, M.D., F.A.C.P.Search for more papers by this author, William Benjamin, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1078_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInsulin has been demonstrated to produce many changes in metabolism in the normal and diabetic organism with such complex interrelationships that the fundamental site or sites of action of the hormone are not yet fully known. Evidence, however, from studies of isolated tissues as well as the intact animal have revealed specific stimulatory actions of insulin on glucose transport across certain cell membranes, intracellular glucose phosphorylation, glycogen synthetase, de novo synthesis of fatty acids from acetate, and mono-unsaturated fatty acid synthesis from saturated fatty acids. Since in most of these instances increased enzyme activity has followed the insulin administration, studies... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Alfred Gellhorn, M.D., F.A.C.P.; William Benjamin, M.D.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlterazioni lipidemiche nel diabete mellitoDiabetic Lipemia 1 May 1965Volume 62, Issue 5Page: 1078-1079KeywordsCell membranesEnzymesFatty acidsGlucoseGlycogensHormonesInsulinLigases ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...
916 Systemic administration of an adenovirus encoding a truncated, soluble dominant negative VEGF (FLK-1/KDR) receptor in a murine tumor model for liver metastasis of colorectal cancer
Authors: V SCHMITZ, T HILBERT, C DZIENISOWIVZ, E RASKOPF, C RABE, T SAUERBRUCH, W CASELMANN
Journal: Hepatology (2003)
Postural Ophthalmodynamometry in Carotid Artery Occlusive Disease
Authors: Raul G. Calderon
Journal: JAMA (1963)

Ophthalmodynamometry measures relative pressure of the retinal arteries and constitutes a rapid and safe test for internal carotid artery occlusive disease. A comparison of the retinal artery pressures when the patient is standing with those or when he is sitting or in a supine position enhances the sensitivity and diagnostic usefulness of the test. The effect of posture on the retinal artery pressure was measured in 58 patients, 20 with carotid artery occlusive disease, 18 with intracranial cerebrovascular disease, and 20 with miscellaneous conditions. The greatest value of postural ophthalmodynamometry was the detection of chronic and bilateral, as well as early, carotid artery occlusive disease. Six cases illustrate the significance of the results.
Should relatives be allowed to watch resuscitation?
Authors: S Adams, M Whitlock, R Higgs, P Bloomfield, P J Baskett
Journal: BMJ (1994)

Should relatives be allowed to watch resuscitation?The sudden death ofsomeone after an accident at a public event can be difficultfor relatives to cope with.Doctors' attention isfocused on the patient, and the needs of relatives are often unheard.Sarah Adams describes herfeelings when her brother died afterfallingfrom his horse at the Windsor international three day event, and a doctor who was on duty at the event gives his view.We asked an anaesthetist who was a member ofthe Resuscitation Council, a cardiologist who runs a resusucitation training course, and a generalpractitioner with a special interest in ethics to comment on Sarah Adams's wish to be present during attempts to resuscitate her brother.
Book Review Primary Immunodeficiency Diseases: A Molecular and Genetic Approach Second edition. Edited by Hans D. Ochs, C.I. Edvard Smith, and Jennifer M. Puck. 726 pp., illustrated. New York, Oxford University Press, 2007. $175. 978-0-19-514774-2
Authors: Thomas A. Fleisher, Mark Ballow
Journal: New England Journal of Medicine (2007)
A SIMPLE AND RAPID TEST FOR ALBUMIN AND OTHER URINARY PROTEINS
Authors: WILLIAM G. EXTON
Journal: JAMA (1923)

While it is true that albuminuria does not always denote renal disease, the inescapable fact remains that albuminuria is almost always the earliest sign of nephritis; and it is generally discoverable months or even years before the symptomatology, the blood chemistry or the most sensitive of renal function tests become diagnostic.<sup>1</sup>Neither clinical nor insurance medicine has as yet taken as thorough cognizance of the importance of minimal amounts of albumin or of the relation of dilution of the specimen to amount of albumin as statistics justify, and chiefly because the albumin tests in common use do not enable one to make precise distinctions between truly persistent and genuinely intermittent albuminurias. <h3>VALUE OF VARIOUS TESTS</h3> As a matter of technical practice, we are accustomed to the use of criteria which are not truthfully informative. For instance, if one uses Heller's test as the criterion, as many do, one is
Affirmative Action, Cuban Style
Authors: Fitzhugh Mullan
Journal: New England Journal of Medicine (2004)

“I feel as if I'm standing on the backs of all my ancestors. This is a huge opportunity for me,” Teresa Glover, a 27-year-old medical student, told me during a recent visit to her medical school. “Nobody in my family has ever had the chance to be a doctor.” Glover's mother is a teacher, and her father a dispatcher for the New York subway system. Her background is a mix of African American, Barbadian, and Cherokee. She graduated from the State University of New York at Plattsburgh. “I wanted to be a doctor, but I wasn't sure how to get . . .
THE EARLY CELLULAR RESPONSE TO ACUTE MYOCARDIAL INFARCTION IS MEDIATED BY CD34+CD45- AND CD14+KDR+ CELLS
Authors: Gareth J. Padfield, Olga Tura, Elizabeth Freyer, G.R. Barclay, Marc Turner, David E. Newby, Nicholas L. Mills
Journal: Journal of the American College of Cardiology (2011)
Propranolol and Epinephrine-Reply
Authors: David M. Kornhauser
Journal: JAMA (1981)

In Reply.—  As Dr Stotter has indicated, a drug interaction between propranolol and epinephrine can occur. Increases in blood pressure (BP) and bradycardia have been described in patients receiving propranolol after receiving intravenous epinephrine 1 and after insulin-induced hypoglycemia. 2 In the latter instance, endogenous epinephrine secreted in response to the hypoglycemia is thought to be responsible for provoking the hypertension. Dr Stotter indicates the postulated mechanism.  Therapy for anaphylaxis is generally directed at reversing bronchoconstriction and supporting the BP. Usually, both epinephrine and fluids are administered to reverse the hypotension. However, careful titration of the BP in this emergency situation is difficult. While patients receiving propranolol might be more sensitive to the pressor effects of epinephrine, I expect that the BP could be maintained at safe levels by adjusting the rate of fluid administration.
A genetic contribution to inflammatory bowel disease in Iceland: A genealogic approach
Authors: Inga Reynisdottir, Daniel F. Gudbjartsson, Johann Heidar Johannsson, Ileana Manolescu, Kristleifur Kristjansson, Kari Stefansson, Jeffrey Gulcher, Sigurdur Bjornsson
Journal: Clinical Gastroenterology and Hepatology (2004)
Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis.
Authors: P M Chavassieux, M E Arlot, C Reda, L Wei, A J Yates, P J Meunier
Journal: Journal of Clinical Investigation (1997)

Treatment effects on bone quality and remodeling was assessed in postmenopausal women with osteoporosis treated with oral alendronate. One transiliac bone biopsy was obtained from 231 women at either 24 mo (n = 11) or 36 mo (n = 120) from the start of treatment with alendronate at doses of between 5 and 20 mg/d, or placebo. 64 biopsies at 24 mo (31 from the placebo group and 33 alendronate-treated patients) and 95 biopsies at 36 mo (40 from the placebo group and 55 alendronate-treated patients) provided adequate cancellous tissue, and were analyzed by histomorphometry. Mineral apposition rate was unaffected by treatment. At 24 and 36 mo, osteoid thickness, volume, and surface significantly decreased. At each of the doses studied, mineralizing surface and activation frequency significantly decreased at each time point (e.g., -92% and -87%, respectively, for the 10 mg daily dose after 2 yr). These diminutions were of the same magnitude for each dose at 24 mo, and for the two highest doses at 36 mo. A significant increase in wall thickness accompanied by a reduction in erosion depth was detected in biopsies obtained at 24 mo. These findings confirm that mineralization is normal, and trabecular bone turnover markedly decreased in patients receiving long-term dosing with alendronate. The findings also suggest that the observed increases in bone mineral density could result both from a reduction in the remodeling space due to a decreased activation frequency and a possible trend to a positive bone balance. In addition, further studies focused on a possible increase in the degree of mineralization of bone are required.
Adoptive transfer of IL13Rα2-specific T cells for the treatment of glioblastoma: building on clinical achievements with second-generation CARs
Authors: Christine E Brown, Renate Starr, Araceli Naranjo, Brenda Aguilar, Wen-Chung Chang, Julie Ostberg, Charles Warden, Yate-Ching Yuan, Massimo D'Apuzzo, Michael E Barish, Behnam Badie, Michael C Jensen, Stephen J Forman
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts The prognosis of patients with high-grade glioma remains grim despite improvements in standard therapies including surgery, radiation and chemotherapy. Immunotherapy approaches targeting brain tumors offer promise over conventional treatments by harnessing the potency and
Recoding can lead to inaccessible structures, but avoids capacity limitations
Authors: Graeme S. Halford
Journal: Behavioral and Brain Sciences (1997)

The distinction between uninformed learning (type-1) and learning based on recoding using prior information (type-2) helps to clarify some long-standing psychological problems, including misunderstanding of mathematics by children, the need for active construction of concepts in cognitive development, and the difficulty of configural learning tasks. However, an alternative to recoding some type-2 tasks is to represent the input as separate dimensions, which are processed jointly. This preserves the original structure, but is subject to processing capacity limitations.
Status of Legislation and Regulatory Control of Public Health Pesticides in Countries Endemic with or at Risk of Major Vector-Borne Diseases
Authors: Graham Matthews, Morteza Zaim, Rajpal Singh Yadav, Agnes Soares, Jeffrey Hii, Birkinesh Ameneshewa, Abraham Mnzava, Aditya Prasad Dash, Mikhail Ejov, Soo Hian Tan, Henk van den Berg
Journal: Environmental Health Perspectives (2011)

Legislation and regulation of pesticides used in public health are essential for reducing risks to human health and the environment.
Abstract 1249: ERK1/2 targeting with magnolin as a chemopreventive agent
Authors: Cheol-Jung Lee, Mee-Hyun Lee, Ji-Young Lee, Ji Hong Song, Yong-Yeon Cho
Journal: Cancer Research (2014)

Abstract Mitogen activated protein kinases (MAPKs) play a key role in cell proliferation, cell cycle progression and cell transformation, and activated Ras/ERKs/RSK2 signaling pathways have been widely identified in many solid tumors. In this study, we found that magnolin, a compound found in Magnolia species, directly targeted and inhibited ERK1 and ERK2 kinase activities with IC50 values of 87 nM and 16.5 nM by competing with ATP in an active pocket, respectively. Further, we demonstrated that magnolin inhibited EGF-induced p90RSKs phopshorylation at Thr359/Ser363, but not ERKs phosphorylation at Thr202/Tyr204, resulted in inhibition of cell proliferation by suppression of G1/S cell cycle transition. Additionally, p38 kinases, Jun N-terminal kinases, and Akts did not involved magnolin-mediated inhibitory signaling. Magnolin targeting on ERK1 and 2 activities suppressed the phosphorylation of RSK2 and downstream target proteins including ATF1 and c-Jun and AP-1, a dimer of Jun/Fos, and the transactivation activities of ATF1 and AP-1. Notably, ERKs inhibition by magnolin suppressed EGF-induced anchorage-independent cell transformation and colony growth of RasG12V- harboring A549 human lung cancer cells and NIH3T3 cells stably expressing RasG12V in soft agar. Taken together, these results demonstrated that magnolin might be a naturally occurring chemoprevention and therapeutic agent capable of inhibiting cell proliferation and transformation by targeting ERK1 and ERK2. Citation Format: Cheol-Jung Lee, Mee-Hyun Lee, Ji-Young Lee, Ji Hong Song, Yong-Yeon Cho. ERK1/2 targeting with magnolin as a chemopreventive agent. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1249. doi:10.1158/1538-7445.AM2014-1249
BCL2 expression in chronic lymphocytic leukemia: lack of association with the BCL2 −938A&gt;C promoter single nucleotide polymorphism
Authors: Aneela Majid, Olga Tsoulakis, Renata Walewska, Stefan Gesk, Reiner Siebert, D. Ben J. Kennedy, Martin J. S. Dyer
Journal: Blood (2007)
Variations in Anxiety Levels during Pregnancy and Psychosocial Factors in Relation to Obstetric Complications
Authors: Renzo Rizzardo, Guido Magni, Carla Cremonese, Rosaria Talamo Rossi, Michele Cosentino
Journal: Psychotherapy and Psychosomatics (1988)

Patterns of variation of state and trait anxiety during pregnancy and after delivery were studied prospectively in relation to some obstetrical and neonatal disturbances. Specific pregnancy anxiety, social support, and coping style were also evaluated. State anxiety in the 3rd month was significantly higher among women with obstetric complications and oscillated during the course of pregnancy, with significantly higher levels in the 3rd and 9th months. No such variations were found in the women with uncomplicated pregnancies. None of the other psychosocial variables examined were related to complications.
Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice
Authors: Hiroshi Kawasaki, Keisuke Nagao, Akiharu Kubo, Tsuyoshi Hata, Atsushi Shimizu, Hideaki Mizuno, Taketo Yamada, Masayuki Amagai
Journal: Journal of Allergy and Clinical Immunology (2012)
Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay
Authors: Nam D. Tran, Xiaoming Liu, Ziying Yan, Duane Abbote, Qinshi Jiang, Eric B. Kmiec, Curt D. Sigmund, John F. Engelhardt
Journal: Molecular Therapy (2003)

Traditional RNA-DNA chimeric oligonucleotides (chimeraplasts), composed of a continuous stretch of RNA and DNA residues in a duplex conformation, have been shown to correct single-base mutations in episomal and genomic DNA both in vitro and in vivo. In the current study, we have compared the efficiency of single-base pair correction between a traditionally designed chimeraplast (covalently linked duplex) and hybrid chimeraplasts (noncovalent duplexes formed from stretches of RNA and DNA nucleotides synthesized individually and hybridized in vitro). Six hybrid chimeraplasts of identical length were constructed with various lengths of target homology and strand location of the desired nucleotide change. These constructs were evaluated for their ability to correct a point mutation in the gene encoding recombinant enhanced green fluorescent protein (eGFP) that rendered the protein nonfluorescent. A plasmid encoding this mutant eGFP gene and a chimeraplast were co-introduced directly into the nuclei of primary fibroblasts by microinjection. As shown by the recovery of eGFP fluorescence, three of the six hybrid chimeraplasts demonstrated the ability to mediate gene correction (0.4–2.4%). Covalent joining of RNA and DNA strands in chimeraplasts was not necessary for correction of DNA mutations. However, the strand placement of the desired nucleotide change and the length of nonhomologous sequences flanking target nucleotides played a crucial role in the efficiency of chimeraplast-mediated gene correction. Despite the ability of certain chimeraplast designs to correct point mutations in episomal plasmids, targeted correction of integrated copies of the mutant eGFP transgene was unsuccessful in primary fibroblasts. These results demonstrate that, although chimeraplasts are fairly effective at targeting episomal DNA in primary cells, further optimization is required to increase the efficiency for targeting integrated genes.
Dysphagia and Esophageal Dilatation
Authors: George F. Zinninger
Journal: JAMA (1966)

Dr. Zinninger: This 75-year-old white man had been in excellent health all of his life until two months before admission to the hospital when he developed a sensation of food sticking in his midesophagus. He had occasionally vomited undigested food. Results of the physical examination were not remarkable. A barium examination of the esophagus at another hospital showed partial esophageal obstruction (Fig 1). <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Wyman, do you have any comments on this? Dr. Stanley M. Wyman: There is an irregularity in the wall of the lower esophagus (Fig 2). It seems to be real and rather constant. There is so much retained material in the esophagus, however, that it is difficult to be certain whether or not this irregularity is real or simply the result of adherent material. The examination should be repeated after esophageal lavage. The lower part of the esophagus tapers in a
A Case of Dysmenorrh a in Which the Tincture of Cannabis Indica Was Employed, with Some Observations upon That Drug
Authors: B. Barrow
Journal: BMJ (1847)

CANNABIS INDICA IN DYSMENORRHCEA.rheumatism, the extension or repression of which disease is, perbaps, one of its most frequently exciting cause.The symptoms from the first were well marked, and require no comment.Upon what the permanent irregularity of the pulse in the right radial artery depended, I am not prepared to say, the stethoscope did not indicate either cardiac or arterial disease; it arose, in all probability, from local pressure upon the artery, but in what part of its course this obtained, repeated examination failed to elicit.
Endothelium-dependent blunted membrane potential responses to ATP-sensitive K+ channel modulators in aortae from rats with cirrhosis
Authors: Philippe Lahaye, Laura Fouassier, Khalid A Tazi, Andrea De Gottardi, Jean-François Fléjou, Carine Chagneau, Jean-Pierre Rona, Chantal Housset, Jürg Reichen, Didier Lebrec, Richard Moreau
Journal: Journal of Hepatology (1999)
Book: Prevention of Micronutrient Deficiencies: Tools for Policy Makers and Public Health Workers
Authors: Z. A. Bhutta
Journal: BMJ (1998)

Johnathan Cape £17.99, pp 292 ISBN 0224 06 0309 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> This is a little gem of a book which, in spite of its small size, contains a vast amount of information. It is a compilation of recommendations and background papers by the Committee on Micronutrient Deficiencies, Food, and Nutrition; the International Health Boards of the US National Institute of Medicine, and other experts, who met in December 1996. There is considerable interest in, and confusion about, micronutrient malnutrition, much of which is subclinical. Even when data on prevalence … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Selection of Patients with Acute Myocardial Infarction for Thrombolytic Therapy
Authors: David W. M. Muller
Journal: Annals of Internal Medicine (1990)

Purpose: To critically review the current recommendations regarding the eligibility of patients with myocardial infarction for thrombolytic therapy. Data Identification: Relevant studies published from January 1980 to January 1990 were identified through a computerized search of the English-language literature using MEDLINE and by a manual search of the bibliographies of all identified articles. Study Selection: All randomized, controlled trials of intravenous thrombolysis in acute myocardial infarction and unstable angina were reviewed. Smaller, observational studies and previous review articles were included when relevant to the discussion. Data Extraction: Key data were extracted from each article, including the proportions of patients eligible for thrombolysis, the reasons for exclusion from thrombolytic therapy, and the clinical outcomes of patients treated and of those excluded from treatment. The validity of certain exclusion criteria was examined using subgroup analysis from the large, randomized mortality trials of intravenous thrombolysis and observations from smaller, nonrandomized studies. Results of Data Synthesis: To date, relatively few patients with myocardial infarction have been considered eligible for fibrinolytic therapy. In this group, both early and late mortality have been significantly reduced. Patients excluded from thrombolysis, however, continue to have a high early mortality. The data suggest that the potential benefits of this treatment might be extended to selected high-risk subgroups. In particular, the risk-benefit ratio may favor the inclusion of otherwise healthy elderly patients; certain patients presenting more than 6 hours after the onset of symptoms; and patients with a history of controlled systolic hypertension or brief, nontraumatic cardiopulmonary resuscitation. The data do not support the use of fibrinolytic therapy as primary treatment in patients with unstable angina or suspected myocardial infarction in the absence of confirmatory electrocardiographic changes. Conclusions: The full potential of thrombolytic therapy to alter the natural history of acute myocardial infarction can only be realized through the continued evaluation of selection criteria and the identification and treatment of the greatest possible number of eligible patients.