tbuckley/cabot-search huggingface dataset:
Coronary thrombolysis with Desmodus salivary plasminogen activator in dogs. Fast and persistent recanalization by intravenous bolus administration.
Authors: W Witt, B Maass, B Baldus, M Hildebrand, P Donner, W D Schleuning
Journal: Circulation (1994)

DSPA (Desmodus salivary plasminogen activator) is a new thrombolytic agent corresponding to a natural plasminogen activator discovered in the saliva of the vampire bat Desmodus rotundus. Compared with tissue plasminogen activator (TPA), DSPA, produced in a recombinant cell line, is more fibrin cofactor dependent than TPA.The thrombolytic properties of DSPA and TPA were compared in a canine model of copper coil-induced coronary thrombosis. All dogs received heparin 200 IU/kg IV and SC. Whereas controls did not reperfuse within 180 minutes (none of six), intravenous bolus administration of DSPA at 25, 50, and 100 micrograms/kg resulted in a 100% incidence (6 of 6) of recanalization within 37, 23, and 18 minutes, respectively. TPA at 63 and 125 micrograms/kg reopened the coronaries in 33% (two of six) and 50% (three of six) of cases within 40 minutes. Eighty-three percent (5 of 6) of the arteries were still patent 3 hours after 50 and 100 micrograms/kg DSPA, whereas only 20% (one of five) of all coronaries originally recanalized with both doses of TPA were still open at 3 hours. Plasma levels of alpha 2-antiplasmin decreased significantly only with 125 micrograms/kg TPA. The clearance of DSPA (2.3 to 3.5 mL.min-1.kg-1) was lower compared with TPA (11.4 to 20 mL.min-1.kg-1) due to a prolonged terminal half-life.In a canine coronary thrombosis model, DSPA exhibited higher potency and recanalized coronary arteries faster and with a lower incidence of reocclusion than TPA. Its properties may translate into a higher efficacy in patients compared with available thrombolytic agents. The long half-life of DSPA may allow for single bolus administration in the treatment of acute myocardial infarction.
Influence of long term physical activity on selected skinfold variables of national level male sports persons
Authors: Dhananjoy Shaw, Seema Kaushik
Journal: British Journal of Sports Medicine (2010)

The aim of present investigation were: (1) to describe the selected skinfold variables of male students of University of Delhi that is, national level sports persons; and (2) to study the effect of long term physical training programme on selected skinfold variables of national level sports persons that is, male volunteers from University of Delhi. The sample size for the study was 90 having three groups of male (namely progressive load or intensive training, constant load or moderate training, no load or control sedentary group); each group having 30 samples (the mean age was 20.04 ± 0.49 years). The variables included skinfold measurements at biceps, triceps, forearm, subscapular, suprailiac, thigh and calf. Standard landmarks and measurement protocols were followed to measure the selected variables as described by various authors. Mean, SD and analysis of covariance were applied to test the variability of covariance as the effect of conditioning programme on selected groups (progressive load or intensive training, constant load or moderate training, no load or sedentary group); at different stages of testing that is, test-1, test-2, test-3, test-4 (intermittent stages of testing) in a longitudinal experimental paradigm of 18 weeks on selected variables of male. The paired t test comparison for mean difference was done as post-hoc analysis. The findings documents that the F-ratios were significant at 0.05 level, which were confirmed by post-hoc analysis at certain intersects of training stages and groups. The level of significance chosen for testing the hypothesis was 0.05. The study concluded that a long term physical activity had a positive effect on selected skinfold variables of national male sports persons that is, male volunteers from University of Delhi.
Increased Threshold for Spike-Timing-Dependent Plasticity Is Caused by Unreliable Calcium Signaling in Mice Lacking Fragile X Gene Fmr1
Authors: Rhiannon M. Meredith, Carl D. Holmgren, Meredith Weidum, Nail Burnashev, Huibert D. Mansvelder
Journal: Neuron (2007)
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias
Authors: N Carbuccia, V Trouplin, V Gelsi-Boyer, A Murati, J Rocquain, J Adélaïde, S Olschwang, L Xerri, N Vey, M Chaffanet, D Birnbaum, M J Mozziconacci
Journal: Leukemia (2009)
New Synthetic Agent for the Induction of Ovulation: Preliminary Trials in Women
Authors: A. Klopper, M. Hall
Journal: BMJ (1971)

A new compound in the triphenylethylene series has been tested for its effect in causing ovulation in secondary amenorrhoea. Twenty patients were given a total of 40 courses of treatment and ovulation resulted in 16 instances. Three patients became pregnant. Probably this compound can induce ovulation in suitable subjects.
Anaphylaxis with clonal mast cells in normal looking skin – a new entity?
Authors: A. Bretterklieber, C. Beham‐Schmid, G. J. Sturm, A. Berghold, R. Brezinschek, W. Aberer, E. Aberer
Journal: Allergy (2015)

Patients with elevated basal tryptase (sBT) >15 μg/l and anaphylaxis may have an underlying mastocytosis. A monoclonal mast cell activation syndrome with aberrant mast cells (MC) at extracutaneous sites has been described in patients with severe hypotension or anaphylaxis.As MC in patients with elevated sBT might be altered in the skin as well, we studied MC in normal neck skin in anaphylaxis and urticaria patients with elevated sBT.A mean of 93.1 (SD 19.1) MC/mm² was counted in normal neck skin in 14 patients with anaphylaxis, 84.0 (SD 13.6) in seven patients with urticaria, 142.0 (SD 24.0) in two patients with eczema, 124.4 (SD 43.2) in five patients with systemic mastocytosis (SM) in comparison with autopsy skin (39.1 MC/mm², SD 12.4). In five of 14 (35.7%) of the anaphylaxis and three of five (60%) SM patients more than 25% of MC were spindle shaped and expressed CD25 antigen.We could show for the first time that the normal skin can harbour clonal MC in anaphylaxis patients. Analogous to the criteria for mastocytosis, we suggest a skin score criteria including an elevated number of MC, spindle shape, CD25 expression, c-Kit mutation and sBT values >20 μg/l. In patients with anaphylaxis and elevated sBT, skin should be biopsied and, as with the approach for mastocytosis diagnosis in the bone marrow, MC should be analysed for their number, clonality and c-Kit mutation. This approach should be confirmed in further studies. Patients with aberrant skin MC should be handled as mastocytosis patients.
Alendronate Approved for Bone Disorders
Authors: Stuart L. Nightingale
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype.
Authors: M Tsai, L S Shih, G F Newlands, T Takeishi, K E Langley, K M Zsebo, H R Miller, E N Geissler, S J Galli
Journal: The Journal of Experimental Medicine (1991)

Mast cell development is a complex process that results in the appearance of phenotypically distinct populations of mast cells in different anatomical sites. Mice homozygous for mutations at the W or S1 locus exhibit several phenotypic abnormalities, including a virtual absence of mast cells in all organs and tissues. Recent work indicates that W encodes the c-kit tyrosine kinase receptor, whereas S1 encodes a c-kit ligand that we have designated stem cell factor (SCF). Recombinant or purified natural forms of the c-kit ligand induce proliferation of certain mast cell populations in vitro, and injection of recombinant SCF permits mast cells to develop in mast cell-deficient WCB6F1-S1/S1d mice. However, the effects of SCF on mast cell proliferation, maturation, and phenotype in normal mice in vivo were not investigated. We now report that local administration of SCF in vivo promotes the development of connective tissue-type mast cells (CTMC) in the skin of mice and that systemic administration of SCF induces the development of both CTMC and mucosal mast cells (MMC) in rats. Rats treated with SCF also develop significantly increased tissue levels of specific rat mast cell proteases (RMCP) characteristic of either CTMC (RMCP I) or MMC (RMCP II). These findings demonstrate that SCF can induce the expansion of both CTMC and MMC populations in vivo and show that SCF can regulate at least one cellular lineage that expresses c-kit, the mast cell, through complex effects on proliferation and maturation.
Lactation from Axillary Tail of Breast
Authors: J. P. Roux
Journal: BMJ (1955)

BRUCELLOSIS AS HAZARD OF TRANSFUSION concurrently with exposure to infection through the blood of an individual known to have been in the bacteriaemic stage of the disease. SummaryA case of brucellosis diagnosed 13 weeks after transfusion with blood from a donor in the bacteriaemic stage of the disease is described.If accepted, it is the first time that such an infection has been reported in this country, but such cases have been confirmed in Mexico.Its occurrence illustrates the importance of question- ing prospective donors about their health and rejecting those who might be in the incubation stage of an infectious disease.The insidious onset of symptoms in undulant fever and the delay which may occur in the development of the antibody response are demonstrated.
744-1 Endogenous Nitric Oxide Attenuates Myocardial Inotropic Responses in Ischemic Myocardium of the Canine Heart
Authors: Koichi Node, Masafumi Kitakaze, Kazuo Komamura, Hiroaki Kosaka, Yuji Okuyama, Hiroharu Funaya, Michihiko Tada, Michitoshi Inoue, Masatsugu Hori, Takenobu Kamada
Journal: Journal of the American College of Cardiology (1995)
Botched execution could lead to legal challenges in death penalty states
Authors: O. Dyer
Journal: BMJ (2014)

US states that impose the death penalty are likely to face a slew of legal challenges and possible moratoriums after an Oklahoma execution that used a new drug cocktail was badly botched. Clayton Lockett awoke, spoke, and struggled several minutes after being pronounced unconscious and up to 16 minutes after being injected with the sedative midazolam.

Witnesses reported that the supervising doctor declared “it’s not working” at 16 minutes, as Lockett writhed and said, “Oh, man.” At this point the curtains of the execution chamber were drawn and the execution halted. But Lockett died of a heart attack 43 minutes after the injection.

The director of Oklahoma’s Department of Corrections, Robert …
Extensive Ossification in a Pulmonary Plasmacytoma
Authors: S. G. Kinare, G. B. Parulkar, S. R. Panday, P. K. Sen
Journal: Thorax (1965)

Extramedullary plasmacytomata form an interest- ing group of tumours, the nature and behaviour of which are still not well understood.The majority of such tumours are situated in the pharynx, upper respiratory tract, and conjunctiva (Hellwig, 1943).Less frequent sites have been the thyroid, intestine, ovary, and kidney.A study of the litera- ture available to us has revealed that so far 18 cases (Ackerman, 1953 ;
Biological influences on criminal behaviour
Authors: J F Soothill
Journal: BMJ (1995)

<b>1044</b> <h3><b>Learning Objectives</b></h3> Unique challenges facing battlefield injuries and neuroimaging, neuroimaging techniques for diagnosing mild TBI, novel PET agents and TBI. <h3></h3> The impact of Traumatic Brain Injury (TBI) on military servicemembers is significant with more than 300,000 Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) soldiers diagnosed with TBIs. The majority of TBIs are classified as ‘mild’ and the classification criteria for mild TBI is based on the following Department of Defense/Department of Veterans Affairs Clinical Practice Guideline: (1) brief loss of consciousness, (2) brief alteration of consciousness, (3) posttraumatic amnesia for 0 to 1 days, or (4) Glasgow Coma Score of 13-15, and (5) a normal non-contrast brain CT. The extent of mild TBI is not well understood and diagnosis is complicated by the varied symptoms that may also be observed in posttraumatic stress disorder (PTSD). The diffuse and subtle injury is typically not detected on conventional head CT studies and many soldiers are ineligible for magnetic resonance imaging (MRI) due to embedded metal fragments as a result of a blast injury. Early diagnosis and the development of an effective treatment for veterans with TBI is a top priority. Novel neuroimaging techniques using various positron emission tomography (PET) imaging agents may provide critical information for diagnosing and evaluating treaments for TBI. For example, TBI results in abnormalities in brain metabolism and cerebral blood flow, which results in a cascade of subtle changes including inflammation, reduced glucose utilization, transient ischemia, angiogenesis, amyloid plaque deposition, and increased DNA synthesis. Novel PET imaging agents may play an important role in diagnosing TBI. This presentation will discuss the role of PET neuroimaging in TBI along with unique challenges associated with translating bench to bedside in a military population
Book Review Meningiomas Edited by Ossama Al-Mefty. 630 pp., illustrated. New York, Raven Press, 1991. $135. Meningiomas and Their Surgical Management Edited by Henry H. Schmidek. 557 pp., illustrated. Philadelphia, W.B. Saunders, 1991. $175.
Authors: William H. Sweet
Journal: New England Journal of Medicine (1991)
Cancer Pain: Assessment and Management
Authors: Devi E. Nampiaparampil
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Participation in Research and Access to Experimental Treatments by HIV-Infected Patients
Authors: Allen L. Gifford, William E. Cunningham, Kevin C. Heslin, Ron M. Andersen, Terry Nakazono, Dale K. Lieu, Martin F. Shapiro, Samuel A. Bozzette
Journal: New England Journal of Medicine (2002)

Although there is concern that minority groups and women are underrepresented in research involving patients with human immunodeficiency virus (HIV) infection, the available data are inconclusive.
Standardization and CD-ROM-Reply
Authors: Richard K. Wertz
Journal: JAMA (1987)

<h3>In Reply.—</h3> I thank Dr Trail for his comments and compliment him on his knowledge of CD-ROM. The intent of my article was to provide physicians with an overview of this new technology and to avoid details that might be confusing and uninteresting. The medium of CD-ROM (the disks themselves) is totally standardized and therefore the drives that play the disks are also standardized. This situation stands in sharp contrast to that of other optical technologies, in which there continues to be lack of standardization of the medium. We are well aware of the split between videocassette recorders (Beta vs VHS) and videodisk systems (CED, Laser-Vision, and VHD). Such problems do not exist with CD-ROM, and this is the point. Dr Trail is correct in saying that there are levels of standardization beyond the physical level. Even though CD-ROM is standardized as a computer peripheral, personal-computer operating systems are not
Proceed With Caution: Predicting Genetic Risks in the Recombinant DNA Era
Authors: A. G. Motulsky
Journal: JAMA (1990)

Medical genetics is in its "golden age." Discoveries that elucidate a variety of genetic diseases are occurring rapidly. The definition of the basic defect in cystic fibrosis in 1989 is a spectacular example that is likely to lead to extensive genetic testing for the carrier state. A book that deals with the social and medical impact of genetic screening is therefore timely and welcome. Dr Holtzman is eminently qualified to write such a book, having spent most of his efforts over the last few years studying and pondering these issues. He starts out by providing the biologic background and explains how modern gene technology can be used in the diagnosis of genetic disease. While the molecular diagnosis of a given genetic defect is usually clear-cut, the resultant clinical manifestations often show variability in age of onset and severity. This axiom is particularly true for common diseases that depend upon interaction
Temporal arteriography. A new technique for the investigation of giant cell arteritis and polymyalgia rheumatica.
Authors: L A Gillanders, R W Strachan, D W Blair
Journal: Annals of the Rheumatic Diseases (1969)

The work which has led to this report was undertaken in an attempt to improve the diagnostic accuracy and thereby the treatment of giant cell arteritis and polymyalgia rheumatica.Whether these conditions are the same, related, or quite different diseases is a well-known problem; detailed studies have provided support for all three possibilities (Gordon, Rennie, and Branwood, 1964;
TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Authors: David J. Drasin, Anna L. Guarnieri, Deepika Neelakantan, Jihye Kim, Joshua H. Cabrera, Chu-An Wang, Vadym Zaberezhnyy, Pierluigi Gasparini, Luciano Cascione, Kay Huebner, Aik-Choon Tan, Heide L. Ford
Journal: Cancer Research (2015)

Epithelial-to-mesenchymal transition (EMT) is a dynamic process that relies on cellular plasticity. Recently, the process of an oncogenic EMT, followed by a reverse mesenchymal-to-epithelial transition (MET), has been implicated as critical in the metastatic colonization of carcinomas. Unlike governance of epithelial programming, regulation of mesenchymal programming is not well understood in EMT. Here, we describe and characterize the first microRNA that enhances exclusively mesenchymal programming. We demonstrate that miR-424 is upregulated early during a TWIST1 or SNAI1-induced EMT, and that it causes cells to express mesenchymal genes without affecting epithelial genes, resulting in a mixed/intermediate EMT. Furthermore, miR-424 increases motility, decreases adhesion, and induces a growth arrest, changes associated with a complete EMT that can be reversed when miR-424 expression is lowered, concomitant with an MET-like process. Breast cancer patient miR-424 levels positively associate with TWIST1/2 and EMT-like gene signatures, and miR-424 is increased in primary tumors versus matched normal breast. However, miR-424 is downregulated in patient metastases versus matched primary tumors. Correspondingly, miR-424 decreases tumor initiation and is posttranscriptionally downregulated in macrometastases in mice, suggesting the need for biphasic expression of miR-424 to transit the EMT-MET axis. Next-generation RNA sequencing revealed miR-424 regulates numerous EMT and cancer stemness-associated genes, including TGFBR3, whose downregulation promotes mesenchymal phenotypes, but not tumor-initiating phenotypes. Instead, we demonstrate that increased MAPK-ERK signaling is critical for miR-424-mediated decreases in tumor-initiating phenotypes. These findings suggest miR-424 plays distinct roles in tumor progression, potentially facilitating earlier, but repressing later, stages of metastasis by regulating an EMT-MET axis.
National Health Service breast screening programme results for 1991-2.
Authors: J Chamberlain, S M Moss, A E Kirkpatrick, M Michell, L Johns
Journal: BMJ (1993)

OBJECTIVES--To report the results of the NHS breast screening programme for the year March 1991 to April 1992. DESIGN--A report of statistics was derived from Körner (K62) returns and from the radiology quality assurance programme. MAIN OUTCOME MEASURES--Detection rates for breast cancer and small (&lt; or = 10 mm diameter) invasive cancer, benign biopsy rates, and recall and acceptance rates. RESULTS--The acceptance rate for screening across the United Kingdom was 71.3%. The referral rate for further investigation was 6.2% (regional 4.3-9.0%). The breast cancer detection rate was 6.2 cancers per 1000 women screened (5.1-9.0) and the detection rate of invasive cancers &lt; or = 10 mm was 1.4/1000 (1.0-2.3). 72% of screening programmes reached the target 70% acceptance rate, and 95% of programmes achieved a recall rate of less than 10%. 75% of programmes had a cancer detection rate of more than 5/1000, but only 32% had a detection rate for invasive cancers &lt; or = 10 mm of more than 1.5/1000. CONCLUSIONS--Overall, the results of the screening programme for the year 1991-2 can be regarded as extremely satisfactory, given the size and complexity of the operation.