tbuckley/cabot-search huggingface dataset:
Familial Iminoglycinuria
Authors: Leon E. Rosenberg, Joseph L. Durant, Louis J. Elsas
Journal: New England Journal of Medicine (1968)

Clinical, biochemical and genetic studies in a family with inherited, renal iminoglycinuria showed that the proband had a prominent renal tubular defect for reabsorption of glycine, proline and hydroxyproline. His parents and several relatives had hyperglycinuria only. No defect in intestinal absorption or transport of glycine or the imino acids was found in the proband. Familial iminoglycinuria is concluded to represent another specific inborn error of transport due to an autosomal mutation. Homozygotes for this mutation are believed to excrete abnormal quantities of the imino acids and glycine whereas heterozygotes excrete excessive glycine only. Glycine is reabsorbed by more than one renal transport system, and the biochemical mechanisms that control intestinal transport of glycine and the imino acids are not identical. The abnormal phenotype noted in iminoglycinuria is very probably due to more than a single abnormal genotype.
EU should strengthen protection against fake drugs, UK report says
Authors: Susan Mayor
Journal: BMJ (2006)

The European Union should strengthen penalties against companies trading in counterfeit drugs, a report from the School of Pharmacy at the University of London recommends. 

It also calls for better monitoring of trading of drugs and better provision of information to the public to try to combat the growing problem of counterfeit drugs. 

The report warns that counterfeiting, which has been a major problem for some years in developing countries, is now increasing in Europe. Recent World Health Organization statistics show that 30% of drugs supplied in developing countries are fake. 

The report documents cases showing that the problem applies to branded and generic products and ranges from the illegal use of copyrighted commercial brands to manufacture of fake drugs. 

In some East European countries, such as Russia, about 10% of drugs are counterfeit, the report notes. In West European countries, such as the United Kingdom, less than 1% (by value) of drugs …
Peter Wynne Harvey
Authors: Margaret Harvey
Journal: BMJ (2006)

​FormerFormer consultant pathologist Lancaster (b 1923; q Manchester 1946), died from Alzheimer's disease on 25 January 2006.



Figure 1



Peter Harvey was born in Birmingham but grew up in Manchester, where he went to medical school. He was appointed consultant pathologist at Blackpool in 1954 at an early age but moved to be head of the department in Lancaster in 1963. In addition to building up a modern department with the various subspecialties, Peter became progressively interested in the application of computing to pathology services when this was a new area. He was treasurer of the first international congress of the European Federation of Medical Informatics at Cambridge in 1978 and read papers at a number of international meetings. In all, he published over 30 papers. He leaves a wife, Margaret; three children; and four grandchildren.
OBSERVATIONS ON THE USE OF HYDEOCORTISONE OINTMENT.
Authors: JOHN K. MORGAN
Journal: British Journal of Dermatology (1955)

Journal Article OBSERVATIONS ON THE USE OF HYDEOCORTISONE OINTMENT. Get access JOHN K. MORGAN, M.R.C.P. JOHN K. MORGAN, M.R.C.P. Senior Registrar, Manchester and Salford Hospital for Skin Diseases Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 67, Issue 5, 1 May 1955, Pages 180–188, https://doi.org/10.1111/j.1365-2133.1955.tb12716.x Published: 01 May 1955
Pulmonary air embolism: radiological changes.
Authors: S Josephson, C O Ovenfors
Journal: Thorax (1969)

Proceedings of the Thoracic Society occluded pulmonary artery, the saturation fell only in those instances when a pressor response was obtained.On bilateral air injection the degree of unsaturation was quantitatively related to the rise in PA pressure.The saturation fell 6-21 % (average 14-3 %).In six experiments, arterial CO2 pressure changed less than ± 2 mm. Hg.During oxygen breathing, embolization lowered the arterial Po2 from 490 to 399 mm.Hg, corresponding to a shunt of 18 % of the cardiac output.This explains only part of the desaturation during air breathing.
The global shift: Shadows of identifiability
Authors: Colin T. Schmidt
Journal: Behavioral and Brain Sciences (2014)

Abstract The presence of overwhelming amounts of information in our big-data era society is growing. Globalisation is increasingly giving these solicitations (regarding information) a more social aspect causing behavioural changes. While restricting my focus on this aspect of the Bentley et al article, I address related medical questions and pin-point the conceptual interest of the roadmap given therein.
Clinical variation in X-linked dominant chondrodysplasia punctata (X-linked dominant ichthyosis)
Authors: L. Feldmeyer, B. Mevorah, K.H. Grzeschik, M. Huber, D. Hohl
Journal: British Journal of Dermatology (2006)

Conflicts of interest: None declared. Chondrodysplasia punctata is a heterogeneous group of skeletal dysplasias characterized by an anomaly of enchondral bone formation causing stippled calcifications that can be visualized radiologically or sonographically. The X‐linked dominant form (Conradi–Hünermann–Happle syndrome, CDPX2) occurs almost exclusively in women and is characterized by asymmetrical limb shortening and cataract as well as a transitory congenital dermatosis presenting as generalized erythroderma with segmental lesions of prominent follicular keratosis. Later, this congenital dermatosis regresses and leaves behind patchy or segmental atrophic skin lesions, mainly follicular atrophoderma. Scarring alopecia is often present. A diffuse, moderate ichthyotic scaling may persist.1, 2 The EBP gene, coding for a Δ8,Δ7‐sterol isomerase involved in cholesterol biosynthesis, was identified as the gene mutated in CDPX2.3, 4 To date, at least 45 disease‐causing mutations have been reported. The mutation spectrum included 15 nonsense, 16 missense, two deletion, seven frameshift, two splice‐site and three intronic mutations, distributed among the five exons as well as introns of the EBP gene, with a majority of mutations encountered in exons 2 and 4.
Translational Medical Research
Authors: Phil B. Fontanarosa, Catherine D. DeAngelis
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Absorption, hallucinations, and the continuum hypothesis
Authors: Joseph Glicksohn
Journal: Behavioral and Brain Sciences (2004)

The target article, in stressing the balance between neurobiological and psychological factors, makes a compelling argument in support of a continuum of perceptual and hallucinatory experience. Nevertheless, two points need to be addressed. First, the authors are probably underestimating the incidence of hallucinations in the normal population. Second, one should consider the role of absorption as a predisposing factor for hallucinations.
The vasodilator potency of atrial natriuretic peptide in man.
Authors: P Bolli, F B Müller, L Linder, A E Raine, T J Resink, P Erne, W Kiowski, R Ritz, F R Bühler
Journal: Circulation (1987)

The vasodilating potency of alpha-human atrial natriuretic peptide (alpha-hANP) was investigated in the forearms of 16 normotensive subjects, 22 to 48 (mean 28) years old, with the use of venous occlusion plethysmography. alpha-hANP, 0.005 to 1.5 micrograms/min/100 ml forearm volume (FAV), infused in nine dose steps into the brachial artery increased forearm blood flow (FAF; ml/min/100 ml FAV) from 2.8 +/- 0.4 (SEM) to a maximum of 9.6 +/- 1.1. Forearm vascular resistance (mean arterial pressure/FAF) decreased by 72%. The alpha-hANP dose that produced a 50% vasodilator response was 0.093 +/- 0.016 microgram/min/100 ml FAV (n = 11) and it resulted in a venous plasma concentration of ANP (pANP) of 115 +/- 7 pmol/liter (normal 2 to 80; radioreceptor assay). Intraindividually, the maximum dose of alpha-hANP induced an increase in FAF that was 60% of the maximum response to sodium nitroprusside (14.1 +/- 1.8). Combined infusions (n = 9) of maximum forearm vasodilator doses of alpha-hANP and nitroprusside increased FAF to 22.7 +/- 3.4; this additive vasodilator effect of alpha-hANP and nitroprusside is consistent with their different actions on the guanylate cyclase system. In man, the direct vasorelaxant effect of alpha-hANP occurs at concentrations within the upper normal range of pANP, suggesting a physiologic vasodilator role for alpha-hANP.
Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial
Authors: Mohammed Z H Farooqui, Janet Valdez, Sabrina Martyr, Georg Aue, Nakhle Saba, Carsten U Niemann, Sarah E M Herman, Xin Tian, Gerald Marti, Susan Soto, Thomas E Hughes, Jade Jones, Andrew Lipsky, Stefania Pittaluga, Maryalice Stetler-Stevenson, Constance Yuan, Yuh Shan Lee, Lone B Pedersen, Christian H Geisler, Katherine R Calvo, Diane C Arthur, Irina Maric, Richard Childs, Neal S Young, Adrian Wiestner
Journal: The Lancet Oncology (2014)
TCT-347 The Efficacy of cystatin C based glomerular filtration rate in the estimation of safe contrast media volume.
Authors: Hyuck-Jun Yoon, Yun-Kyeong Cho, Hyun-Ok Cho, Seung-Ho Hur, In-Cheol Kim, Hyungseop Kim, Yoon-Nyun Kim, Kwon-Bae Kim, Chang-Wook Nam, Hyoung-Seob Park
Journal: Journal of the American College of Cardiology (2013)
Radial Artery Bypass Grafts Have an Increased Occurrence of Angiographically Severe Stenosis and Occlusion Compared With Left Internal Mammary Arteries and Saphenous Vein Grafts
Authors: Umesh N. Khot, Daniel T. Friedman, Gosta Pettersson, Nicholas G. Smedira, Jianbo Li, Stephen G. Ellis
Journal: Circulation (2004)

Background— The radial artery has been increasingly used in CABG. However, angiographic outcome data have been limited. Methods and Results— We reviewed all coronary angiography procedures from February 1996 to October 2001 and selected patients with a radial artery bypass graft. Angiographic outcomes were divided into groups as (1) occluded, (2) severe disease (≥70% stenosis, or string sign), or (3) patent (&lt;70% stenosis). Multivariable analyses determined predictors of severe disease or occlusion. A total of 310 patients had a radial artery graft. Mean follow-up after coronary artery bypass grafting was 565±511 days. Radial artery grafts had a patency rate of 51.3%, which was significantly lower than that for left internal mammary arteries (90.3%, P &lt;0.0001) or saphenous vein grafts (64.0%, P =0.0016). Radial artery grafts had an occlusion rate of 33.7%, compared with 4.8% for left internal mammary arteries ( P &lt;0.0001), and had a severe stenosis rate of 15.1%, compared with 5.9% for saphenous vein grafts ( P =0.0003) and 4.8% for left internal mammary arteries ( P &lt;0.0001). Women had a worse overall radial artery patency rate than men (38.9% versus 56.1%, P =0.025). A radial artery graft was the most powerful multivariable predictor of severe stenosis or occlusion (χ 2 =28.87, P &lt;0.0001). Because of diseased radial artery grafts, 58 patients required subsequent percutaneous intervention, and 26 patients required repeat CABG. Conclusions— In patients predominantly presenting with signs and symptoms of myocardial ischemia after CABG, radial artery grafts have lower patency rates than left internal mammary artery and saphenous vein grafts. Selective use of the radial artery is warranted, particularly in women.
The Diversity of Life
Authors: Paul R. Epstein
Journal: JAMA (1993)

From his quiet perch deep in the heart of the Amazon, Edward O. Wilson draws us into the wondrous panoply of The Diversity of Life , as his new work is entitled. The observations of this eminent biologist resonate with those made by Charles Darwin over a century and a half before, as  fledgling naturalist stood on the Galapagos Islands, awestruck and, at the time, baffled by the variety of all things, living and inert. But while Darwin strove to understand that mystery of mysteries The Origin of the Species , Wilson grapples with their decline—a decline gathering steam as fossils of past eras are unearthed, consumed as fuel, and exhausted into the land, sea, and air. According to Professor Wilson, species extinction is now occurring at between 1000 and 10 000 times background rates, stretching over millennia; and the World Health Organization estimates  between one fourth and one half
Characterization of a developmental toxicity dose-response model.
Authors: E M Faustman, D G Wellington, W P Smith, C A Kimmel
Journal: Environmental Health Perspectives (1989)

The Rai and Van Ryzin dose-response model proposed for teratology experiments has been characterized for its appropriateness and applicability in modeling the dichotomous response data from developmental toxicity studies. Modifications were made in the initial probability statements to reflect more accurately biological events underlying developmental toxicity. Data sets used for the evaluation were obtained from the National Toxicology Program and U.S. EPA laboratories. The studies included developmental evaluations of ethylene glycol, diethylhexyl phthalate, di- and triethylene glycol dimethyl ethers, and nitrofen in rats, mice, or rabbits. Graphic examination and statistical evaluation demonstrate that this model is sensitive to the data when compared to directly measured experimental outcomes. The model was used to interpolate to low-risk dose levels, and comparisons were made between the values obtained and the no-observed-adverse-effect levels (NOAELs) divided by an uncertainty factor. Our investigation suggests that the Rai and Van Ryzin model is sensitive to the developmental toxicity end points, prenatal deaths, and malformations, and appears to model closely their relationship to dose.
ENCEPHALITIS IN ST. LOUIS
Authors: J. P. LEAKE
Journal: JAMA (1933)

During the five weeks from August 7 to September 10, inclusive, there have been reported in St. Louis City and St. Louis County 656 cases of encephalitis. It appears that the epidemic incidence for this area will not exceed a rate of about one case per thousand of population, and the reported extension of the infection to other places has thus far been remarkably slight. The case fatality rate will be about 20 per cent. Only 13 per cent of the cases have occurred among the 25 per cent of the population which is under 15 years of age, and 23 per cent of the patients have been in the age group 15 to 34 years, which comprises 35 per cent of the total population. The recovery rate in these two age groups has been relatively high, with about half as many deaths in proportion to the number of cases
Clinical Crossroads Update: A 65-Year-Old Man With Poorly Controlled Type 2 Diabetes Mellitus-Reply
Authors: Erin Hartman
Journal: JAMA (1997)

<h3>In Reply.</h3> —We asked Dr S, the patient's primary care physician, to reply: Dr S: Dr Saudek expresses important concerns, which I share. My follow-up notes on the patient were intended to be descriptive; they were not intended to imply any complacency on my part or on the patient's. He is at risk for serious complications, and he is fully aware of that risk, although I would respectfully suggest that Saudek's 27-story-fall metaphor is a bit hyperbolic since we cannot predict with any degree of certainty which, if any, complications he will develop. This patient is an educated man who has on his own explored the medical literature, has been evaluated by an ophthalmologist and a neurologist, has been treated by a respected vascular surgeon, and has willingly participated in an open discussion with our distinguished consultant, Dr Rubenstein. While he appreciates that all these members of his health care team are
Psychiatric study of patients with severe burn injuries.
Authors: A C White
Journal: BMJ (1982)

About two-thirds of a consecutive series of patients severely injured with burns followed up one year after discharge were found to have psychological sequelae. Duration of hospital stay and the presence of certain mental illnesses were related to the incidence and severity of psychological symptoms. This relation did not apply to the site of the burn and the existence of a claim for compensation. The incidence of post-traumatic neurosis in patients with burn injuries could be reduced by identifying and treating, soon after the accident, those who need psychiatric help.
The Occasion Fleeting
Authors: William B. Bean
Journal: JAMA (1960)

The title of Hugh Barber's "The Occasion Fleeting" comes from the best known Hippocratic aphorism. It deals with his medical career and presents a wise philosophical review of many of the changes which have come over the face of English medicine during the past fifty years. Although some items of the English and London scene are mainly of local interest, there is no problem in finding all kinds of items interesting to anyone concerned with the practice of medicine. The subjects range over a wide field of prechnical and clinical medical education: provincial and London hospitals; the influence of pathology, consultants, and specialists; family physicians; clinical skill; the spirit of the family doctor, relatives, and friends; sports; geriatrics; psychosomatic medicine, and annual "check-ups." It concludes with a series of charming essays entitled "Doctors' Dilemmas." Here is a welcome breath of fresh air for anyone whose olfactory fatigue with the dark
Surgery vs Orthosis vs Watchful Waiting for Hallux Valgus
Authors: Markus Torkki, Antti Malmivaara, Seppo Seitsalo, Veijo Hoikka, Pekka Laippala, Pekka Paavolainen
Journal: JAMA (2001)

ALLUX VALGUS IS A VERY COMmon foot deformation.Among those who wear shoes, 33% of adults have some degree of hallux valgus. 1 Although nonsurgical care is always the first option for a patient who has a hallux valgus deformity, 2 hallux valgus surgery is among the most common orthopedic operations in Western industrialized countries.It has been estimated that 209000 people in the United States undergo hallux valgus surgery every year. 3In Finland (population 5 million), the most common orthopedic operations in 1998 were knee arthroscopy (23 621 per year), hip arthroplasty (4424), extirpation of low back disk prolapse (4030), knee arthroplasty (3959), and correction of hallux valgus (3909). 4ore than 100 techniques have been introduced for correction of hallux valgus. 1 Distal metatarsal (chevron) osteotomy is widely used to correct mild or moderate hallux valgus. 5In uncontrolled case series, good clinical results have been reported in 80% to 90% of patients who have undergone the surgery. 6-8However, recurrences or undercorrections have been reported in 10% to 14% of the cases. 5,9,10onservative treatments aim to reduce the angle of the first metatarsal-great toe joint by either stretching contracted soft tissue around the joints with the use of night splints, and improving muscle strength by foot exercises or resolving abnormal function with insoles (orthoses). 11Orthoses are considered to be most effective in the early stages of hallux valgus. 12vidence for effectiveness of surgical and conservative treatments for patients with hallux valgus is very lim-ited.A recently published systematic review found only 12 randomized trials concerning surgical or conservative treatment of hallux valgus. 11None of the studies compared surgical treatment with any conservative treatment or with watch-
Major histocompatibility complex-restricted H-Y-specific antibodies and cytotoxic T lymphocytes may recognize different self determinants.
Authors: E Goulmy, A van Leeuwen, E Blokland, J J van Rood, W E Biddison
Journal: The Journal of Experimental Medicine (1982)

Previous studies have shown that influenza virus-immune cytotoxic T lymphocytes can recognize virus in conjunction with self HLA-A2 antigens. Nevertheless, the virus-infected target cells from one HLA-A2-positive male donor (designated M7) could not be lysed by the virus-immune cytotoxic lymphocytes from any HLA-A2-matched unrelated donors. Although extensive serological analyses showed no difference between the HLA-A2 antigens of donor M7 and other HLA-A2-positive donors, isoelectric focusing of the HLA-A2 molecule from donor M7 revealed a clear difference in the heavy polypeptide chains when compared with the HLA-A2 molecules of other donors. The present study demonstrates that the HLA-A2-restricted anti-H-Y cytotoxic T lymphocytes obtained from a female aplastic anaemia patient fail to lyse the male M7 target cells, whereas the HLA-A2-restricted anti-H-Y antibodies from the same patient react with the cells of donor M7. These results suggest that: (a) HLA-A2-restricted anti-H-Y antibodies can recognize self determinants on the HLA-A2 molecule that are distinct from those that are recognized by HLA-A2-restricted anti-H-Y cytotoxic T cells; and (b) HLA-restricted T and B cells may use different receptor repertoires for the recognition of foreign antigens such as H-Y.
Li Zhisui, MD
Authors: Joanne C. Gerstner
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal