Primary Aldosteronism Due to an Adrenal Carcinoma
Authors: MILTON G. CRANE
Journal: Annals of Internal Medicine (1965)

Case Studies1 September 1965Primary Aldosteronism Due to an Adrenal CarcinomaMILTON G. CRANE, M.D., F.A.C.P., JOHN J. HARRIS, M.D., F.A.C.P., RAYMOND HERBER, M.D.MILTON G. CRANE, M.D., F.A.C.P.Search for more papers by this author, JOHN J. HARRIS, M.D., F.A.C.P.Search for more papers by this author, RAYMOND HERBER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-3-494 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrimary aldosteronism is a syndrome characterized by hypokalemic alkalosis and hypertension. Benign adrenal cortical adenomas have been the cause of this syndrome in most of the patients reported in the literature. A few patients have had a malignancy as the cause of their defect. This is a case report of a patient with typical clinical and laboratory findings of primary aldosteronism caused by an adrenocortical carcinoma.CASE REPORTThe patient was a 64-year-old female (Figure 1) who was first seen at the White Memorial Clinic in April, 1963, for hypertension and weakness. The patient was first aware that she had...References1. CRANEHARRISHOLLOWAY MGJJJE: Exchangeable sodium and potassium in primary aldosteronism. J. Lab. Clin. Med. 61: 51, 1963. MedlineGoogle Scholar2. NEHERWETTSTEIN RA: Physicochemical estimation of aldosterone in urine. J. Clin. Invest. 35: 800, 1956. CrossrefMedlineGoogle Scholar3. HARRISCRANE JJMG: Urinary cortisol excretion as a test of adrenal cortical function. Metabolism 13: 45, 1964. CrossrefMedlineGoogle Scholar4. DREKTERHEISLERSCISMSTERNPEARSONMCGAVACK IJAGRSSTH: The determination of urinary steroids. I. The preparation of pigment-free extracts and a simplified procedure for the estimation of total 17-ketosteroids. J. Clin. 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ROMANIALBEAUX-FERNETCHABOTKELLERLARRIEU JDMJAH: Clinical, biological and anatomicopathologic study of case of hypermineralocorticism with peripheral edema and hypokalemia. Presse Med. 67: 1969, 1959. MedlineGoogle Scholar24. WESTKUMAGAISIMONSDOMINGUEZBERLINER CDLFELOVDL: Adrenocortical carcinoma with feminization and hypertension associated with a defect in 11β-hydroxylation. J. Clin. Endocr. 24: 567, 1964. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Department of Internal Medicine, School of Medicine, Loma Linda University, Loma Linda, Calif.This investigation was supported by research grants HE-4745 and HE-5758 and Career Development Award K3-GM-7627 from the U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Milton G. Crane, M.D., Loma Linda University, Loma Linda, Calif. 92354. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPathophysiology, Diagnosis, and Treatment of Mineralocorticoid DisordersAldosterone-Producing Adrenocortical CarcinomaIsolated primary aldosteronism in adrenocortical carcinoma: A case report and review of literatureMineralocorticoid Excess Secondary to Adrenal Cortical CarcinomaPure primary hyperaldosteronism due to adrenal cortical carcinomaPrimary aldosteronism due to adrenal carcinomasCarcinoma of the adrenal cortex causing primary hyperaldosteronism. A case report and review of the literatureThe treatment of low-renin (“primary”) hyperaldosteronismLow-renin (“primary”) hyperaldosteronismClinical, biochemical and pathological features of low-renin (“primary”) hyperaldosteronismNeoplasms of the Adrenal CortexThe Renin-Angiotensin SystemPerspectives on the renin-angiotensin-aldosterone system in hypertensionThe use of spironolactone in the diagnosis and the treatment of hypertension associated with mineralocorticoid excessThe regulation of aldosterone secretion in primary aldosteronismAldosterone: Physiological and pathophysiological variations in manReaction of fluoroolefins with salts of thiol acidsREFERENCESThe Control of Aldosterone Secretion and Its Relationship to the Diagnosis of HyperaldosteronismPrimary adrenocortical carcinoma causing aldosteronismAdrenalectomy in Cases of Severe Renal SclerosisSurgery of the Adrenal GlandAdrenalectomy for Lesions of the Adrenal Gland 1 September 1965Volume 63, Issue 3Page: 494-503KeywordsAdenomasClinical laboratoriesCortisolExcretionHypertensionLesionsMedical servicesResearch grantsResearch laboratories Issue Published: 1 September 1965 PDF downloadLoading ...