Chronic Diarrhea and Malabsorption Associated with Enteropathogenic Bacterial Infection in a Patient with AIDS
Authors: D P Kotler, J M Orenstein
Journal: Annals of Internal Medicine (1993)

Brief Reports15 July 1993Chronic Diarrhea and Malabsorption Associated with Enteropathogenic Bacterial Infection in a Patient with AIDSDonald P. Kotler, MD and Jan M. Orenstein, MD, PhDDonald P. Kotler, MDFrom St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, New York, and George Washington University School of Medicine, Washington, DC.Search for more papers by this author and Jan M. Orenstein, MD, PhDFrom St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, New York, and George Washington University School of Medicine, Washington, DC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-2-199307150-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Chronic diarrhea and weight loss are common in patients with the acquired immunodeficiency syndrome (AIDS) [1]. Although several infectious causes may be found, no cause is identified in as many as 50% of cases [1-4]. Other possible causes include as yet unidentified pathogens, the human immunodeficiency virus (HIV) itself [5], and noninfectious processes. We describe a patient who had evidence of chronic intestinal injury associated with enteropathogenic bacterial infection.Case ReportA 33-year-old white homosexual man with AIDS and Kaposi sarcoma was seen because of diarrhea of 3 months duration and 11 kg weight loss. He claimed 10 to 40 ...References1. Connolly GM, Shanson D, Hawkins DD, Webster JN, Gazzard BG. Non-cryptosporidial diarrhoea in human immunodeficiency virus (HIV) infected patients. Gut. 1989; 30:195-200. Google Scholar2. Rene E, Marche C, Regnier B, Saimot AG, Vilde JL, Perrone C, et al. Intestinal infections in patients with acquired immunodeficiency syndrome. A prospective study in 132 patients. Dig Dis Sci. 1989; 34: 773-80. Google Scholar3. Kotler DP. Intestinal and hepatic manifestations of AIDS. In: Stollerman GH, Harrington WJ, Lamont JT, Lennard JJ, Siperstein MD; eds. Advances in Internal Medicine Chicago: Yearbook Medical Publishers. 1988; 34:43-71. Google Scholar4. Smith PD, Lane HC, Gill VJ, Manischewitz JF, Quinnan GV, Fauci AS, et al. Intestinal infections in patients with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1988; 108:328-33. Google Scholar5. Ullrich R, Zeitz M, Heise W, L'age M, Hoffken G, Riecken EO. Small intestinal structure and function in patients infected with human immunodeficiency virus (HIV): evidence for HIV-induced enteropathy. Ann Intern Med. 1989; 111:15-21. Google Scholar6. Rothbaum RJ, Partin JC, Saalfield K, McAdams AJ. An ultrastructural study of enteropathogenic Escherichia coli infection in human infants. Ultrastruct Pathol. 1983; 4:291-304. Google Scholar7. Rothbaum R, McAdams AJ, Gianella R, Partin JC. A clinicopathologic study of enterocyte-adherent Escherichia coli: a cause of protracted diarrhea in infants. Gastroenterology. 1982; 83:441-54. Google Scholar8. Dougan G. Molecular characterization of bacterial virulence factors and the consequences for vaccine design. J Gen Microbiol. 1989; 135: 1397-406. Google Scholar9. Kotler DP, Tierney AR, Scholes JV. Intestinal plasma cell alterations in the acquired immunodeficiency syndrome. Dig Dis Sci. 1987; 32: 129-38. Google Scholar Author, Article, and Disclosure InformationAuthors: Donald P. Kotler, MD; Jan M. Orenstein, MD, PhDAffiliations: From St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, New York, and George Washington University School of Medicine, Washington, DC.Corresponding Author: Donald P. Kotler, MD, Section of Gastrointestinal Immunology, S&R 1301, St. Luke's-Roosevelt Hospital Center, 421 West 113th Street, New York, NY 10025.Grant Support: In part by grant AI21414 from the National Institutes of Health. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComplications of HIV/AIDS and other secondary immunodeficienciesEnteric Escherichia coli InfectionsOpportunistic disorders of the gastrointestinal tract in the age of highly active antiretroviral therapyThe pathology of malabsorption: current conceptsEnteropathogenic Escherichia coliLight microscopic and electron microscopic diagnosis of gastrointestinal opportunistic infections in HIV-positive patientsThe Histopathology of 103 Consecutive Colonoscopy Biopsies From 82 Symptomatic Patients With Acquired Immunodeficiency SyndromeDünndarmveränderungen bei AIDSDiagnosis and Treatment of Colonic Disease in AIDSDiarrheogenic bacterial enteritis in acquired immune deficiency syndrome: A light and electron microscopy study of 52 casesNatural history and prognosis of diarrhoea of unknown cause in patients with acquired immunodeficiency syndrome (AIDS).Enteroaggregative Escherichia coli As a Possible Cause of Diarrhea in an HIV-Infected PatientNutrition and HIV infectionWasting Syndrome: Nutritional Support in HIV InfectionBACTERIAL INFECTIONS IN HIV-INFECTED PATIENTSMorphologic Evaluation of the Pathogenesis of Bacterial Enteric Infections - Part IMorphologic Evaluation of the Pathogenesis of Bacterial Enteric Infections - Part II 15 July 1993Volume 119, Issue 2Page: 127-128KeywordsAIDSBacteriaBiopsyDiarrheaElectron microscopyInfantsLesionsToxinsWeight lossXylose ePublished: 15 August 2000 Issue Published: 15 July 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. 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