tbuckley/cabot-search huggingface dataset:
PTPN22 R620W may affect age at onset and survival of SSC patients
Authors: S. Kokkali, D. Hristova, H. Kirsten, P. Ahnert, N. Hunzelmann, P. Vaith, I. Melchers
Journal: Annals of the Rheumatic Diseases (2011)

<h3>Background and objectives</h3> The PTPN22 SNP rs2476601 (1858C→T, R620W) shows association with several autoimmune diseases including SSc. Here we analyse data from SSc patients concerning the time-dependent development of the disease from early to late stages, dependent on their R620W genotype. <h3>Materials and methods</h3> SSc patients (N=235, 81.3% female) were recruited in the University Medical Centers in Freiburg and Cologne. Genomic DNA was purified from peripheral blood. Genotyping was done applying single base extension and MALDI-TOF mass spectrometry (genoSNIP; Bruker Daltonics, Leipzig, Germany) or PCR and RFLP. Statistic analysis was performed using PASW Statistics 18.0. <h3>Results</h3> The means of age at onset of Raynaud phenomenon, skin involvement and organ involvement of all patients resembled published data.1 Of 232 patients genotyped, 19.8% carried the minor T allele and 80.2% did not. T-neg patients were older at onset of RP, skin and organ involvement than T-pos patients (RP: N=169, 47.3±14.7 years vs N=42, 41.3±14.6 years; skin involvement: N=162, 51.4±13.4 years vs N=40, 44.9±13.6 years; organ involvement: N=163, 53.5±12.9 years). These differences were significant for RP (p=0.019) and skin involvement (p=0.006). From 183 patients data on age at onset of RP, skin involvement and organ involvement were available, of whom 157 (85.8%) started with RP, followed by skin involvement and later on organ involvement. Also in this group, T-neg patients were older than T-pos. patients (RP: 48.5± 4.2 vs 40.6±14.3, p=0.004; skin involvement: 51.3±12.9 vs 44.8±13.8, p=0.011; organ involvement: 54.1±12.6 vs 49.1±14.0, p=0.048). In addition, we analysed the frequencies of T-pos patients dependent on the observation time between the age at last contact and the age at onset of RP (A), skin (B) or organ (C) involvement, again in the group of 157 patients. In all three comparisons (A, B and C) the percentages of T-pos patients increased continuously from short to long observation periods, indicating a possible positive effect of the presence of the minor T-allele on survival. <h3>Conclusions</h3> T-pos patients develop disease at an earlier age, but show no difference in progression time. The frequency of T-pos patients was higher in groups of patients observed for a longer period of time, implicating a longer survival period.
Joint Meeting of Advisory Committees
Authors: Jane E. Henney
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Which patients with chronic hepatitis B virus infection will respond to α-interferon therapy? A statistical analysis of predictive factors
Authors: Gary M. Brook, Peter Karayiannis, Howard C. Thomas
Journal: Hepatology (1989)

Twenty–one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given α–interferon for chronic hepatitis B virus infection. In those patients who had received a minimum of 90 million units per m 2 total dose over 12 weeks, a negative anti–human immunodeficiency virus antibody status (p &lt; 0.001), chronic active hepatitis on liver biopsy (p &lt; 0.005), high AST level (p &lt; 0.001), low hepatitis B virus DNA level (p &lt; 0.001) and a history of acute hepatitis (p &lt; 0.005) were all associated with an increased likelihood of response on univariate analysis. On stepwise logistic regression analysis, hepatitis B virus DNA, AST and a history of acute hepatitis predicted response independently (p &lt; 0.05). The most reliable combination of predictive factors was a negative anti–human immunodeficiency virus antibody status, with either a positive history of acute icteric hepatitis and AST &gt; 45 IU per liter or no history of acute icteric hepatitis and AST &gt; 85 IU per liter, which predicted response in 77% with a specificity of 79% (p &lt; 0.001). The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of &lt;2 years duration (p &lt; 0.001).
DISSEMINATED LUPUS ERYTHEMATOSUS WITH INVOLVEMENT OF THE SPINAL CORD
Authors: Philip G. Piper
Journal: JAMA (1953)

A review of the literature on involvement of the central nervous system in disseminated lupus erythematosus revealed no case of focal involvement of the spinal cord in addition to the other protean manifestations. Since Hebra and Kaposi and Bowen described mental changes associated with this disease, Daly and Sedgwick and Von Hagen have more completely summarized the clinical and pathological findings. They reported toxic delirium and coma in association with the anatomic alterations of diffuse nonspecific encephalitis, as well as vascular changes and thrombosis producing myelomalacia of the nervous parenchyma secondary to disturbances in the vascular supply. The following case is reported because of the unusual finding of vascular changes with thrombosis of the meningeal vessels resulting inischemic necrosis of the lumbar cord. REPORT OF A CASE A 19-year-old white girl who had disseminated lupus erythematosus was admitted to the University Hospitals for the sixth time on May 3, 1952.
Squamous Cell Carcinoma of the Prostate With Strong FDG Uptake on PET/CT
Authors: Aisheng Dong, Changjing Zuo, Jianping Lu, Yang Wang
Journal: Clinical Nuclear Medicine (2013)

Primary squamous cell carcinoma (SCC) of the prostate is a rare aggressive neoplasm with a poor prognosis. A 60-year-old man presented with urinary frequency and interrupted urination for 4 months. Serum prostate-specific antigen and SCC antigen were elevated. T2-weighted MR images showed a hyperintense lesion in the central area of the prostate. FDG PET/CT showed strong FDG uptake of the lesion with SUVmax of 15.5. Prostate biopsy revealed moderate differentiated SCC. This case indicates SCC of the prostate should be considered in the differential diagnosis of abnormal prostate FDG accumulation (especially with elevated SCC antigen level).
IgE against HIV proteins in clinically healthy children with HIV disease
Authors: Elizabeth A. Secord, Gary I. Kleiner, Dominick L. Auci, Tamar Smith-Norowitz, Seto Chice, Anna Finkielstein, Maya Nowakowski, Senih Fikrig, H.G. Durkin
Journal: Journal of Allergy and Clinical Immunology (1996)
Socioeconomic determinants of health: Community marginalisation and the diffusion of disease and disorder in the United States
Authors: R. Wallace, D. Wallace
Journal: BMJ (1997)

<h3>Abstract</h3> This article describes the cascading diffusion of "inner city problems" of disease and disorder in the United States–from the huge marginalised inner city communities of the largest municipalities, first along national travel routes to smaller cities, and then from central cities into surrounding more affluent suburbs–following the pattern of the daily journey to work. Public policies and economic practices which increase marginalisation act to damage the "weak ties" of the community social networks which bind central city neighbourhoods into functioning units. Spreading disease and disorder can be interpreted as indices of the resulting social disintegration, which is driven by policy. This "failure of containment" in the United States should serve as a warning for cities in Europe against reducing the municipal and other services that they provide to "unpopular" subpopulations.
Cytochemical “normal” and “abnormal” eosinophils in acute leukemias
Authors: Vincenzo Liso, Giuseppe Troccoli, Giorgina Specchia, Maddalena Magno
Journal: American Journal of Hematology (1977)

Eosinophilic leukocytes may accompany a great variety of disorders and different types of acute leukemias. The most striking morphologic feature of eosinophils is their specific granules, but morphology alone often is insufficient to differentiate normal from abnormal eosinophils. Cytochemically, the eosinophils were considered "normal" when they did not contain alkaline phosphatase, chloroacetate esterase, toluidine blue metachromasia, Astra blue positivity, and specific PAS-positive granules, but did have peroxidase and cyanide-resistant peroxidase activities, Sudan black positivity and moderate naphthol-AS esterase or alpha-naphthyl esterase and acid phosphatase positivities. In seven cases of acute leukemias (two acute myeloblastic and five myelomonocytic), in contrast with their normal behaviour, the eosinophils show "abnormal" cytochemical positivities consisting of chloroesterase activity, PAS and Astra blue positivities of the specific granules, toluidine blue metachromasia, and cyanide-resistant peroxidase of a few specific granules. Cytochemical investigations may provide additional criteria for evaluating the abnormality of the eosinophilic cell in leukemias.
Cyclophosphamide Prevents Systemic Keratinocyte Growth Factor-induced Up-Regulation of Surfactant Protein A after Allogeneic Transplant in Mice
Authors: SHUXIA YANG, ANGELA PANOSKALTSIS-MORTARI, DAVID H. INGBAR, SADIS MATALON, SHA ZHU, ERNESTO R. RESNIK, CATHERINE L. FARRELL, DAVID L. LACEY, BRUCE R. BLAZAR, IMAD Y. HADDAD
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

We reported that systemic keratinocyte growth factor (KGF) given before bone marrow transplantation (BMT) prevents allogeneic T cell-dependent lung inflammation assessed on Day 7 post-BMT, but the antiinflammatory effects of KGF were impaired in mice injected with both T cells and conditioning regimen of cyclophosphamide (Cy). Intratracheal KGF is known to stimulate the expression of surfactant protein A (SP-A), an oxidant-sensitive T cell immunomodulator produced by alveolar type II cells. We hypothesized that systemic KGF up-regulates SP-A after allogeneic BMT, and the addition of Cy may interfere with the ability of KGF to enhance SP-A production. The subcutaneous administration of recombinant human KGF (5 mg/kg on Days -6, -5, and -4 pre-BMT) increased SP-A protein and mRNA in allogeneic T cell-recipient irradiated mice measured on Day 7 post-BMT. In contrast, the same KGF treatment in irradiated mice given T cells and Cy failed to up-regulate SP-A mRNA and protein expression. In mixed lymphocyte reaction experiments designed to simulate the in vivo model, the addition of human SP-A (5-50 microg) to alloactivated T cells suppressed the production of interleukin-2 in a dose-dependent fashion. We conclude that the systemic pre-BMT injection of KGF in recipients of allogeneic T cells up-regulates SP-A, which may contribute to the early antiinflammatory effects of KGF. The protective KGF-mediated SP-A production is abolished in mice given alloreactive T cells plus Cy.
Reverse remodeling and enhancedadrenergic reserve from passive externalsupport in experimental dilated heart failure
Authors: W.Federico Saavedra, Richard S Tunin, Nazareno Paolocci, Takayuki Mishima, George Suzuki, Charles W Emala, Pervaiz A Chaudhry, Petros Anagnostopoulos, Ramesh C Gupta, Hani N Sabbah, David A Kass
Journal: Journal of the American College of Cardiology (2002)
Radionuclide and hemodynamic assessment of left ventricular functional reserve in patients with left ventricular aneurysm and congestive cardiac failure. Response to exercise stress and isosorbide dinitrate.
Authors: J D Stephens, D S Dymond, R A Spurrell
Journal: Circulation (1980)

The hemodynamic response to exercise stress was assessed in 17 patients with left ventricular (LV) aneurysm, demonstrated by contrast left ventriculography, and congestive cardiac failure (CCF) before and after sublingual isosorbide dinitrate (ISDN). Radionuclide ventriculography was performed at rest and during exercise in 14 patients. ISDN increased mean exercise LV stroke work index (LVSWI) from 31 to 39 g-m/m2 (p less than 0.001) and reduced mean exercise LV filling pressure from 38 to 25 mm Hg (p less than 0.001). Using the combined criteria of LVSWI and ejection fraction of the contractile section of the left ventricle (EFCS), no patient with rest EFCS of less than 40% achieved a good absolute response to exercise in LV performance with or without ISDN. Of the six patients with rest EFCS greater than or equal to 40% only three achieved a good response. While rest EFCS less than 40% indicates poor LV functional reserve, good LV functional reserve is not always indicated by rest EFCS greater than or equal to 40%.
Comparison of Four Early Posttherapy Imaging Changes (EPTIC; RECIST 1.0, Tumor Shrinkage, Computed Tomography Tumor Density, Choi Criteria) in Assessing Outcome to Vascular Endothelial Growth Factor–Targeted Therapy in Patients With Advanced Renal Cell Carcinoma
Authors: Katherine M. Krajewski, Mengye Guo, Annick D. Van den Abbeele, Jeffrey Yap, Nikhil Ramaiya, Jyothi Jagannathan, Daniel Y.C. Heng, Michael B. Atkins, David F. McDermott, Fabio A.B. Schutz, Ivan Pedrosa, Toni K. Choueiri
Journal: European Urology (2011)
CMR Assessment of Myocarditis in Patients With Cardiac Symptoms During H1N1 Viral Infection
Authors: Sophie Mavrogeni, Costas Bratis, Anastasia Kitsiou, Genovefa Kolovou, Menelaos N. Manoussakis, Evangelia Papadopoulou, Anastasios Magoutas, Gregory Pavlides
Journal: JACC. Cardiovascular imaging (2011)
Reply: Adjunctive vitamin E treatment in Wilson disease and suggestions for future trials
Authors: Roderick H. J. Houwen, Francisca H. H. Linn, Karel J. van Erpecum
Journal: Hepatology (2010)

We have read with interest the suggestion by Shen and Ji to include vitamin E in future therapeutic trials of zinc in patients with hepatic manifestations of Wilson disease (WD). We do endorse this suggestion for any patient with acute liver failure due to WD or other diseases due to copper overload.1 In these patients, hepatocyte apoptosis is induced by activation of the Fas pathway through oxidative damage.2 Inhibition of this devastating effect of copper overload through the restoration of the intracellular oxidative balance by vitamin E supplementation would probably be beneficial and outbalance potential side effects. We have some hesitation, however, about accepting the suggestion of potential benefits of vitamin E in patients with chronic liver damage due to WD. As Shen and Ji rightly point out, the results of vitamin E and other antioxidants in many chronic diseases are disappointing3 and might even be detrimental,4 as we have described for patients with cystic fibrosis, for example.5 Before the introduction of another intervention with a questionable effect, it is necessary to first properly describe, in a substantial number of patients, the results of decoppering medications that are already available, such as trientine, zinc, and D-penicillamine. Up to January 2008, well-described evidence for efficacy in hepatic WD had been published for only 57 patients on D-penicillamine, 9 patients on zinc, and none on trientine.6 Because prospective randomized trials are not available, a retrospective analysis of patients on any of these medications, like the analysis that we performed for exclusive zinc monotherapy,7 will aid physicians in choosing the optimal medication for their patients with hepatic or neurological WD. Roderick H. J. Houwen*, Francisca H. H. Linn §, Karel J. van Erpecum , * Department of Pediatrics, University Medical Center, Utrecht, The Netherlands, Department of Neurology, University Medical Center, Utrecht, The Netherlands, Departments of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands, § Department of Neurology, Central Military Hospital, Utrecht, The Netherlands.
Influence of dietary protein supplements on the formation of bacterial metabolites in the colon.
Authors: B Geypens, D Claus, P Evenepoel, M Hiele, B Maes, M Peeters, P Rutgeerts, Y Ghoos
Journal: Gut (1997)

BACKGROUND: To evaluate the influence of increased dietary protein intake on bacterial colonic metabolism in healthy volunteers. METHODS: Short chain fatty acids, ammonia, and volatile organic compounds in faecal samples, and phenols in the urine of five volunteers were measured after one week of basal nutrient intake and and after one week of a diet supplemented with a protein rich food (Fortimel; Nutricia, Zoetermeer, The Netherlands). Paired t tests and factor analysis were used for statistical analysis. RESULTS: Total energy and resistant carbohydrate intake remained unchanged in each study period. The percentage energy intake delivered as dietary protein, increased significantly (from 15.4% to 23.8%; p = 0.007) during supplement intake. A significant increase in faecal ammonia (p = 0.002), faecal valeric acid (p = 0.02), and urinary p-cresol (p = 0.04) was noted during supplementary protein intake. A total of 120 different volatile compounds were isolated from the faecal samples of which 10 increased significantly during dietary protein supplementation. The change in volatile pattern, especially for S containing metabolites, was clearly shown by a factor analysis model which made a distinction between the two dietary regimens for all volunteers. CONCLUSION: An increase in dietary protein leads to altered products formation by colonic metabolism, mainly reflected by an increase in faecal ammonia, faecal volatile S substances, and urinary p-cresol.
Vasopressin-independent renal urinary concentration: Increased rBSC1 and enhanced countercurrent multiplication
Authors: Mari Michimata, Kazuhiko Mizukami, Michiko Suzuki, Itsuro Kazama, Yohsuke Nakamura, Katsuya Suzuki, Teruyuki Yanagisawa, Yutaka Imai, Sei Sasaki, Mitsunobu Matsubara
Journal: Kidney International (2003)
Interpreting Bisphenol A Absorption in the Canine Oral Cavity: Gayrard et al. Respond
Authors: Véronique Gayrard, Marlène Z. Lacroix, Séverine H. Collet, Catherine Viguié, Alain Bousquet-Melou, Pierre-Louis Toutain, Nicole Picard-Hagen
Journal: Environmental Health Perspectives (2013)
Air ionisation and colonisation/infection with methicillin-resistant Staphylococcus aureus and Acinetobacter species in an intensive care unit
Authors: Kevin G Kerr, Clive B Beggs, Stephen G Dean, Judith Thornton, Judith K Donnelly, Neil J Todd, P Andrew Sleigh, Andleeb Qureshi, Charles C Taylor
Journal: Intensive Care Medicine (2006)
The Stable Nitroxide Tempol Facilitates Salivary Gland Protection during Head and Neck Irradiation in a Mouse Model
Authors: Joseph M. Vitolo, Ana P. Cotrim, Anastasia L. Sowers, Angelo Russo, Robert B. Wellner, Stanley R. Pillemer, James B. Mitchell, Bruce J. Baum
Journal: Clinical Cancer Research (2004)

Abstract Purpose: Radiotherapy is commonly used to treat a majority of patients with head and neck cancers. The long-term radiation-induced reduction of saliva output significantly contributes to the posttreatment morbidity experienced by these patients. The purpose of this study was to test the ability of the stable-free radical Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), an established radioprotector, to prevent radiation-induced salivary hypofunction in mice. Experimental Design: The heads of C3H mice were exposed to a range of single radiation doses with or without an i.p. injection of 275 mg/kg Tempol 10 min before treatment. Salivary gland output was assessed 8 weeks postirradiation. Results: Radiation caused a dose-dependent reduction in salivary flow in this model. Tempol treatment alone significantly reduced radiation-induced salivary hypofunction. The combination of Tempol with mouth/nose shielding showed essentially complete radiation protection at 15 Gy and ∼75% protection at 17.5 Gy. Conclusions: This study demonstrates for the first time that significant radioprotection of the salivary glands is possible with Tempol in C3H mice.
Inhibition of Receptor Signaling and of Glioblastoma-derived Tumor Growth by a Novel PDGFRβ Aptamer
Authors: Simona Camorani, Carla L Esposito, Anna Rienzo, Silvia Catuogno, Margherita Iaboni, Gerolama Condorelli, Vittorio de Franciscis, Laura Cerchia
Journal: Molecular Therapy (2014)

Platelet-derived growth factor receptor β (PDGFRβ) is a cell-surface tyrosine kinase receptor implicated in several cellular processes including proliferation, migration, and angiogenesis. It represents a compelling therapeutic target in many human tumors, including glioma. A number of tyrosine kinase inhibitors under development as antitumor agents have been found to inhibit PDGFRβ. However, they are not selective as they present multiple tyrosine kinase targets. Here, we report a novel PDGFRβ-specific antagonist represented by a nuclease-resistant RNA-aptamer, named Gint4.T. This aptamer is able to specifically bind to the human PDGFRβ ectodomain (Kd: 9.6 nmol/l) causing a strong inhibition of ligand-dependent receptor activation and of downstream signaling in cell lines and primary cultures of human glioblastoma cells. Moreover, Gint4.T aptamer drastically inhibits cell migration and proliferation, induces differentiation, and blocks tumor growth in vivo. In addition, Gint4.T aptamer prevents PDGFRβ heterodimerization with and resultant transactivation of epidermal growth factor receptor. As a result, the combination of Gint4.T and an epidermal growth factor receptor-targeted aptamer is better at slowing tumor growth than either single aptamer alone. These findings reveal Gint4.T as a PDGFRβ-drug candidate with translational potential.