tbuckley/cabot-search huggingface dataset:
Abstract 4901: Polycomb group proteins in myelodysplastic syndromes and its progression to acute myeloid leukemia
Authors: Zi-Xing Chen, Hong-jie Shen, Jian-nong Cen, yuan-yuan Wang, Jun He, Xiao-fei Qi
Journal: Cancer Research (2010)

Abstract Polycomb group BMI-1 and EZH2 in addition to SALL4 and P16 were detected in 89 MDS bone marrow including 49 newly diagnosed MDS and 40 treated MDS by using qRT-PCR. We found the expression level of BMI-1, EZH2, SALL4 and P16 were remarkably higher than that in non-MDS cytopenias, such as iron-deficiency anemia (P&amp;lt;0.05). BMI1 expression level has an increasing tendency from MDS-RA to MDS-RAEB without statistically significant. On the contrary, the EZH2 expression level of MDS-RAEB is lower than that of MDS-RA (P&amp;lt;0.05). Although BMI1 expression level was down-regulated when MDS patients were in morphological remission, EZH2, SALL4 and P16 expression levels still remain abnormally high level (P&amp;lt;0.05). We also found that BMI-1 expression level in MDS CD34+ cells was correlated with International Prognostic Scoring System (IPSS) score (R=0.712, P=0.012). BMI-1 had the highest positive rate in MDS-AML. To explore the function of BMI-1 and its possible role in the pathogenesis of MDS transformation into acute leukemia. We have cloned cDNA of BMI-1 and transfected into U937, K562 leukemic cells mediated by MSCV retroviral vector. The viability In vitro of BMI1 transfected cell was higher than control and BMI1 transfected cell also inhibited As2O3-induced apoptosis. Furthermore, BMI1 repressed the expression of EZH2, PTEN and P16 in U937, and repressed the expression of EZH2 and PTEN in K562. Our results provide evidence suggesting that the clonal disorder of MDS patients remained in molecular aberration even after achieving clinical remission. The In vitro results suggest that BMI-1 may play a key role in MDS progression via P16 pathway or PTEN pathway. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4901.
TRYPANOSOMA CRUZI CRUZI IN THE TISSUES OF THE ARMADILLO
Authors: BOWMAN CORNING CROWELL
Journal: JAMA (1923)

In 1912, Chagas<sup>1</sup>reported finding<i>Trypanosoma cruzi</i>in the hind gut of<i>Triatoma geniculata</i>, which was collected in the burrows of the armadillo (<i>Tatusia novemcincta</i>) in the zone in which American trypanosomiasis is endemic. Following this he found the trypanosomes in the blood of the armadillo, from which he was able to infect guinea-pigs, and these presented all the phenomena of parasitization by<i>Trypanosoma cruzi</i>. Since then the trypanosome has been found in the blood of the armadillo in places far removed from human habitations. From these findings Chagas concluded that the armadillo is the vertebrate reservior of<i>Trypanosoma cruzi</i>. The trypanosome of the armadillo is carried by<i>Triatoma geniculata</i>, which accidentally frequents human residences, infecting human beings; and the human infection is carried on by<i>Triatoma megista. Triatoma infestans</i>and<i>Triatoma sordida</i>have also been found infected, and Chagas concluded that several kinds of blood-sucking insects may act
Buying Health Care, the Individual Mandate, and the Constitution
Authors: Sara Rosenbaum, Jonathan Gruber
Journal: New England Journal of Medicine (2010)

In Rashomon, a classic film that explores the concept of truth, director Akira Kurosawa presents a story about a single incident retold by four narrators, leaving the audience to figure out what is real. Litigation has a Rashomon-like quality to it: two sides meet in a courtroom and each presents its case, arguing not only that abstract legal principles favor its cause, but equally important, that its version of the event that gave rise to the dispute should be the filter through which the court decides the matter.Three separate cases raising constitutional challenges to the Affordable Care Act . . .
Physiology of Canine Intraventricular Conduction and Endocardial Excitation
Authors: ROBERT J. MYERBURG, KRISTINA NILSSON, HENRY GELBAND
Journal: Circulation Research (1972)

The sequence of conduction through the intraventricular conducting system and endocardial muscle was studied by microelectrode mapping of large areas of isolated canine ventricular tissue. We found that most of the endocardium of the right ventricular free wall is activated simultaneously whereas the left endocardial muscle is activated in an apex-to-base sequence. Right septal activation is from apex to base, and the left septum is activated first at the junction of the middle and lower thirds of the septum and then as a bidirectional wave front toward the apex and the base. These right-left differences occur because the sites of impulse input into muscle on the right encompass the entire free wall, base of the papillary muscle, and the lowermost septum, and on the left are primarily limited to the lower ventricular cavity, lower septum, and bases of the papillary muscles. These patterns of left ventricular excitation relate to the presence of a functionally continuous ring of conducting tissue formed by a merger of the major divisions of the left bundle branch on the upper left ventricular free wall. The "ring" itself is electrophysiologically isolated from muscle, but connects to a network of subendocardial conducting tissue extending to the apex and having input to muscle only in its lower portions.
Immunisation triggering rheumatoid arthritis?
Authors: A S Jawad, D G Scott
Journal: Annals of the Rheumatic Diseases (1989)

<h3>Abstract</h3> Deciding between two equally appealing options can take considerable time. This observation has puzzled economists and philosophers, because more deliberation only delays the reward. Here we show that this seemingly irrational behavior is explained by the constructive use of memory. Using functional brain imaging in humans, we show that how long it takes to decide between two familiar food items is related to activity in the hippocampus, within specific regions shown to be associated with the retrieval of long-term memories. Moreover, we show that value is partially constructed during deliberation to resolve preference, and this constructive process changes behavior and brain responses. These results render memory as a supplier of evidence in value-based decisions, resolving a central paradox of choice.
Rate of Sedimentation of Red Cells as a Clinical Test
Authors: E. Scott
Journal: BMJ (1938)

preparations are available, when a true substitutive therapy can be-carried out, the most hopeful preparation seems to be the serum gonadotropic hormone alone or combined with the urinary gonadotropic hormone.No differentiation has been made between primary and secondary amenorrhoea, as it has been found that when congenital defects are excluded the findings are com- parable in both types, and therefore the treatment is similar.The prognosis is just as favourable in primary as in secondary amenorrhoea.Summary 1.The investigation required in a case of amenorrhoea is detailed, and some consideration is given to the value of each procedure.2. The primary and secondary factors responsible for the inhibition of menstruation are discussed.3. The results of treatment based on the investigation findings are presented.
The role of in vivo confocal microscopy in the diagnosis of eyelid margin tumors: 47 cases
Authors: Elisa Cinotti, Jean Luc Perrot, Nelly Campolmi, Bruno Labeille, Marine Espinasse, Damien Grivet, Gilles Thuret, Philippe Gain, Catherine Douchet, Fabien Forest, Maher Haouas, Frédéric Cambazard
Journal: Journal of the American Academy of Dermatology (2014)
Treating Stella: the story comes first
Authors: D. Loxterkamp
Journal: BMJ (2014)

Radiolabeled peptides are of increasing interest in nuclear oncology. Special emphasis has been given to the development of peptides labeled with positron emitters. Among these, <sup>68</sup>Ga deserves special attention, because it is available from an inhouse generator rendering <sup>68</sup>Ga radiopharmacy independent of an onsite cyclotron. <sup>68</sup>Ga has a half-life of 68 min and decays by 89% through positron emission. The parent, <sup>68</sup>Ge, is accelerator produced and decays with a half-life of 270.8 d by electron capture. Currently, at least 1 commercial and several in-house generators are available. <sup>68</sup>Ge is strongly absorbed on metal oxides or organic material, making a <sup>68</sup>Ge-breakthrough highly unlikely. Several groups continue to further develop generators to remove cationic impurities from the eluate. Several bifunctional chelators based on 1,4,7-triazacyclononane-<i>N,N′,N″</i>-triacetic acid and 1,4,7,10-tetraazacyclododecane-<i>N,N′,N″,N‴-</i>tetraacetic acid (DOTA) macrocycles are available for coupling to peptides and other biomolecules. In addition to these hydrophilic chelators, a lipophilic tetradentate S<sub>3</sub>N ligand was developed. Radiopeptides for <sup>68</sup>Ga labeling have been developed and tested preclinically for the targeting of somatostatin receptors, the melanocortin 1 receptor, and the bombesin receptor. Clinical studies were performed with <sup>68</sup>Ga-DOTA,Tyr<sup>3</sup>-octreotide, localizing neuroendocrine tumors with higher sensitivity than <sup>111</sup>In-diethylenetriaminepentaacetic acid-octreotide. In addition, <sup>68</sup>Ga-DOTA-based bombesin derivatives are being investigated with some success in patients with prostate cancer. <b>Conclusion:</b> Generator-produced <sup>68</sup>Ga and the development of small chelator-coupled peptides (and other small biomolecules) may open a new generation of freeze-dried, good manufacturing practice–produced, kit-formulated PET radiopharmaceuticals similar to <sup>99</sup>Mo-/<sup>99m</sup>Tc-generator–based, <sup>99m</sup>Tc-labeled radiopharmaceuticals.
Destiny of the Republic: A Tale of Madness, Medicine and the Murder of a President
Authors: Dennis Rosen
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapid quantitative assay of ADAMTS13 activity on an automated coagulation analyzer: Clinical applications and comparison with immunoblot method
Authors: Mary Ann Knovich, Heather L. Lawson, Martha H. Burke, Thomas P. McCoy, John Owen
Journal: American Journal of Hematology (2008)

Facile assays for ADAMTS13, the metalloprotease that is absent or impaired in thrombotic thrombocytopenic purpura, could allow for timely diagnosis and management of this potentially fatal hematologic disorder; unfortunately, available assays employ methodologies that restrict use to only a few reference laboratories, resulting in reporting delays. Measurement of ADAMTS13 on an automated analyzer could allow widespread accessibility by routine clinical laboratories. We adapted a previously published technique to demonstrate that ADAMTS13 activity could be measured on an Instrumentation Laboratory automated coagulation analyzer after plasma digestion of a commercial source of von Willebrand factor (VWF). Results were obtained using a commercially available immunoturbidimetric assay for residual VWF activity. Samples from 114 patients with suspected thrombotic microangiopathy were analyzed by both standard immunoblot and our new semiautomated method with excellent agreement, particularly at the clinically relevant low levels of ADAMTS13 activity. This new method is semiautomated and offers quantitative results within 2 hr; our modifications allow for widespread applicability on instrumentation already in use by routine clinical laboratories.
Effects of inflammatory disease on plasma oxprenolol concentrations.
Authors: M J Kendall, C P Quarterman, H Bishop, R E Schneider
Journal: BMJ (1979)

When single oral doses of oxprenolol were given to three healthy subjects on three separate occasions under standardised conditions the plasma concentration-time curves for each subject were closely similar. In two of the subjects, however, a mild illness led to a dramatic, temporary increase in the peak plasma concentration and area under the plasma concentration-time curve (AUC). This effect of inflammatory disease was confirmed by comparing a group of patients with an erythrocyte sedimentation rate (ESR) of over 20 mm in the first hour with a group whose ESR was below this value. The mean peak plasma concentration and AUC were significantly higher in the group with a raised ESR. This may be related to altered concentrations of one of the acute-phase proteins. Thus it is concluded that plasma oxprenolol concentrations are raised in inflammatory disease, but further work is needed to determine the mechanism of this increase.
Antiphospholipid antibodies (aPL) in systemic lupus erythematosus. Are they specific tools for the diagnosis of aPL syndrome?
Authors: A Ghirardello, A Doria, A Ruffatti, A M Rigoli, P Vesco, A Calligaro, P F Gambari
Journal: Annals of the Rheumatic Diseases (1994)

OBJECTIVE--Antiphospholipid antibody (aPL) specificity for aPL-related events was evaluated in systemic lupus erythematosus (SLE). METHODS--A study was carried out on 105 patients affected with SLE comparing the prevalence of lupus anticoagulant (LA) and IgG and IgM anticardiolipin antibodies (aCL) between patients with and without features of antiphospholipid syndrome (APS). Antiphospholipid antibody profile was subsequently evaluated in the aPL positive patients with and without aPL-related events, thus excluding the patients with complications of APS possibly due to factors other than aPL. RESULTS--LA showed a strong association with thrombosis and livedo reticularis, and IgG aCL with thrombosis and neurological disorders, while no clinical features were associated with IgM aCL. A considerable number of aPL positive patients with no aPL-related manifestations was also observed, suggesting the low specificity of aPL assays (54.4%). When studying the 60 aPL positive patients, LA was specific (91.3%) for the diagnosis of aPL-related thrombosis, whereas aCL were not specific, although IgG aCL mean levels were higher in patients with arterial thrombosis than in those without APS features. CONCLUSIONS--LA but not aCL positivity is a specific tool for the diagnosis of thrombotic complications due to aPL in SLE.
Enhanced Coronary Vasoconstriction to Endothelin-BReceptor Activation in Experimental Congestive Heart Failure
Authors: Charles R. Cannan, John C. Burnett, Amir Lerman
Journal: Circulation (1996)

Background Endothelin (ET), a coronary vasoconstrictor, mediates its activity through the specific receptors ET-A and ET-B, which may demonstrate different activity under pathophysiological conditions. Thoracic inferior vena cava constriction (TIVCC) is an experimental model of congestive heart failure that is characterized by a decrease in cardiac output and an increase in circulating ET concentrations. The present study was designed to test the hypothesis that experimental heart failure altered coronary vascular responsiveness to ET-A– and ET-B–receptor stimulation in vivo. Methods and Results ET-1 was infused at a rate of 2 ng/kg per minute into the left circumflex coronary artery in normal dogs (n=5) and in dogs subjected to TIVCC (TIVCC dogs, n=6). Similarly, sarafotoxin, an ET-B–receptor agonist, was infused at the same dosage in normal (n=5) and TIVCC (n=6) dogs. Intracoronary infusion of ET-1 significantly decreased coronary blood flow and increased coronary vascular resistance in normal dogs; this effect was significantly attenuated in TIVCC compared with normal dogs. The percent changes in coronary blood flow and coronary vascular resistance in the TIVCC compared with the normal dogs was −11±8% versus −48±7% ( P &lt;.01) and 29±10% versus 105±23% ( P &lt;.01), respectively. There was no significant effect on coronary blood flow, coronary vascular resistance, or coronary artery diameter in normal dogs that received an intracoronary infusion of sarafotoxin. In contrast, the administration of intracoronary sarafotoxin in TIVCC compared with normal dogs resulted in significant percent changes in coronary blood flow and coronary vascular resistance (−31±4% versus −7±3% [ P &lt;.001] and 53±12% versus 12±8% [ P &lt;.02], respectively). Conclusions The present study demonstrates an attenuated coronary vasoconstrictor response to ET-1 with an enhanced vasoconstrictor response to sarafotoxin and suggests an alteration in coronary ET receptor sensitivity in experimental heart failure.
Atrial natriuretic peptide concentrations in pre-eclampsia.
Authors: J K Thomsen, T L Storm, G Thamsborg, M de Nully, B Bodker, S Skouby
Journal: BMJ (1987)

The concentration of plasma immunoreactive atrial natriuretic peptide is positively associated with right atrial and pulmonary capillary wedge pressure, suggesting that blood volume and hence atrial pressure govern its release. Expansion of plasma volume is a central physiological adjustment in normal pregnancy. Conversely, pregnancies complicated by pre-eclampsia are associated with a reduction in plasma volume and central venous pressure. A study was therefore undertaken to test the hypothesis that plasma atrial natriuretic peptide concentrations are low in pre-eclampsia owing to deficient secretion. Concentrations of the peptide were measured by a specific radioimmunoassay. The mean plasma immunoreactive atrial natriuretic peptide concentration in healthy pregnant women (n = 22; third trimester) was higher (56 (1 SD 29) ng/l) than in 25 young, non-pregnant controls (37 (19) ng/l). Concentrations in patients suffering from mild pre-eclampsia (n = 9) were higher (127 (60) ng/l) than in normal pregnant women, and in patients with severe pre-eclampsia (n = 6) concentrations were higher still (392 (225) ng/l). Despite failure of plasma volume expansion and low central venous and pulmonary capillary wedge pressures in pre-eclampsia this condition is associated with greatly increased plasma concentrations of plasma immunoreactive atrial natriuretic peptide, which increase still further with the severity of the disease. These findings are clear evidence that atrial pressure may not be the principal determinant of the release of the natriuretic peptide in pre-eclampsia.
Cardiac Catheterization and Angiocardiography: An Introductory Manual
Authors: David H. Spodick
Journal: JAMA (1970)

In a compact and handsomely illustrated manual of 172 pages, the authors transcend their declared purpose of providing cardiology trainees with a background in radiology and radiologists with a background in hemodynamics. They provide not only a down-to-earth "how to do it" course in cardiac, arterial, and venous catheterization, but also clear guidelines to the interpretation of results. The attention to detail, particularly regarding technical problems and anomalous results, is one of its strongest features. Only rarely are there omissions (eg, a meticulous discussion of venous catheter insertion omits mention of ligatures). The illustrated descriptions of manipulation of catheters in the right and left portions of the heart, with accompanying line drawings, are as close to the real thing as a text can get. The authors have not restricted themselves to pressure measurement only but include the use of phonocardiographic catheters and electrode catheters for diagnosis and pacing. Supplementing the
THE PREVENTION OF RICKETS IN PREMATURE INFANTS
Authors: HENRY J. GERSTENBERGER
Journal: JAMA (1926)

It is conceded that premature infants and twins are more susceptible to the development of rickets,<sup>1</sup>spasmophilia<sup>2</sup>and anemia<sup>3</sup>than are full term normal infants. The minerals calcium and iron are known to be deposited in greater amounts during the later months of pregnancy, and consequently it has been realized that infants born earlier than full term possess a smaller and an inadequate mineral stock and soon after birth run short,<sup>4</sup>even though they are breast fed. This condition has been accepted generally as the reason, or at least the principal reason, for the increased incidence of the diseases mentioned above in premature and twin infants. Another cause offered by some is that many premature infants suffer from what is termed "debility"; that is, as a whole they are less efficient human machines, and consequently present pathologic conditions sooner and with greater facility, and in severer
Metabolic Problems Related to Prolonged Dialytic Maintenance of Life in Oliguria
Authors: John F. Maher
Journal: JAMA (1961)

Hemodialysis has maintained some patients with acute renal failure through periods of extreme catabolism and prolonged oliguria. Of 37 patients who survived with the aid of 1 to 6 hemodialyses, the duration of oliguria ranged from 7 to 34 days, and among patients who did not survive one was maintained for 181 days despite true oliguria. Metabolic problems that arise under these conditions include defective wound healing, crystallization of oxalates in the renal parenchyma, a general decline in the nitrogenous fractions of endogenous metabolism, an abnormal amino acid pattern, and nutritional deficiences. Data from a number of cases illustrate the problems that need to be solved when a patient is maintained through a prolonged period of oliguria.