AGRANULOCYTOSIS ASSOCIATED WITH PROMAZINE ADMINISTRATION: REPORT OF THREE CASES
Authors: GERALD L. GLASER
Journal: Annals of Internal Medicine (1958)

Article1 February 1958AGRANULOCYTOSIS ASSOCIATED WITH PROMAZINE ADMINISTRATION: REPORT OF THREE CASESGERALD L. GLASER, M.D., DONALD A. ADAMS, M.D.GERALD L. GLASER, M.D.Search for more papers by this author, DONALD A. ADAMS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-2-372 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChlorpromazine has been widely administered for several years. Two of the most serious complications reported from its use are jaundice and agranulocytosis. Forty-five cases of the latter were collected in a report in 1956,1 and several more have been added since, with an estimated incidence of less than 0.3%. Other reviews of this problem have appeared recently in the literature.2, 3Promazine† has been increasingly popular since the early favorable reports of its use in May, 1956.4, 5It differs structurally from chlorpromazine only in the absence of a chloride radical in the 2-position of the phenothiazine ring. Reports of...Bibliography1. : Blood dyscrasias associated with chlorpromazine therapy, J. A. M. A. 160: 287 (Jan. 28) 1956. Google Scholar2. ShickVirks GJ: Agranulocytosis associated with chlorpromazine therapy, New England J. Med. 255: 798 (Oct. 25) 1956. CrossrefMedlineGoogle Scholar3. PlatzerGlaser RFGL: Agranulocytosis due to chlorpromazine, New York State J. Med. 57: 1424 (Apr. 15) 1957. MedlineGoogle Scholar4. FazekasSchultzSullivanShea JFJDPDJG: Management of acutely disturbed patients with promazine (Sparine), J. A. M. A. 160: 46 (May 5) 1956. CrossrefGoogle Scholar5. Mitchell EH: Treatment of acute alcoholism with promazine (Sparine), J. A. M. A. 160: 44 (May 5) 1956. CrossrefMedlineGoogle Scholar6. WoodwardSolomon DJJD: Fatal agranulocytosis occurring during promazine (Sparine) therapy, J. A. M. A. 162: 1308 (Dec. 1) 1956. CrossrefMedlineGoogle Scholar7. ChiricoCarfagnoLytel ASF: Agranulocytosis after promazine therapy: report of a case, New England J. Med. 256: 899 (May 9) 1957. CrossrefMedlineGoogle Scholar8. DaussetNennaBrecy JAH: Leukoagglutinins. V. Leukoagglutinins in chronic idiopathic or symptomatic pancytopenia and in paroxysmal nocturnal hemoglobinuria, Blood 9: 696 (July) 1954. CrossrefMedlineGoogle Scholar9. Myant NB: Treatment of thyrotoxicosis by radioiodine, in Therapeutic use of artificial radioisotopes, edited by Hahn, P. F., 1956, p. 148, John Wiley and Sons, Inc., London. Google Scholar10. FeldmanBertonePanthel PEJH: Fatal agranulocytosis during treatment with Pacatal, Am. J. Psychiat. 113: 842 (Mar.) 1957. CrossrefMedlineGoogle Scholar11. KrackeParker RRFP: The etiology of granulocytopenia (agranulocytosis), J. Lab. and Clin. Med. 19: 799 (May) 1934. Google Scholar12. Dameshek W: Hemotoxic reactions to drugs, Postgrad. Med. 16: 369, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 1, 1957.From the Department of Medicine, Strong Memorial Hospital, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.Requests for reprints should be addressed to Gerald L. Glaser, M.D., 28 Strathallan Park, Rochester, N. Y.†Sparine—Wyeth Laboratories, Inc., Philadelphia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhenothiazine BibliographiesPhenothiazine und Azaphenothiazine als HeilmittelAgranulocytosis and Jaundice during Therapy with Meprobamate and PromazineAGRANULOCYTOSIS FOLLOWING THERAPY WITH PHENOTHIAZINE DERIVATIVES 1 February 1958Volume 48, Issue 2Page: 372-379KeywordsAntibioticsAsthmaBronchitisChloridesChlorpromazineDentistryDiarrheaEmphysemaHospital medicinePhenothiazine Issue Published: 1 February 1958 PDF downloadLoading ...