tbuckley/cabot-search huggingface dataset:
Improved fold width and increased acid secretion after eradication of the organism in Helicobacter pylori associated enlarged fold gastritis.
Authors: Y Yasunaga, Y Shinomura, S Kanayama, M Yabu, T Nakanishi, Y Miyazaki, Y Murayama, J J Bonilla-Palacios, Y Matsuzawa
Journal: Gut (1994)

This study examined the effects of eradication of Helicobacter pylori (H pylori) infection on gastric mucosal morphology and acid secretion. Sixteen H pylori positive patients with enlarged gastric body folds were divided into two groups: (a) patients with moderate enlargement (fold width: 6 to 10 mm, n = 8) and (b) patients with severe enlargement (> 10 mm, n = 8). After successful treatment, gastric body fold width was reduced in both groups (p < 0.01) with an associated decrease in inflammatory infiltrates in the body mucosa (p < 0.01 and p < 0.05). Basal acid output and tetragastrin stimulated maximal acid output (mean (SEM)) in all 16 patients significantly increased from 1.1 (0.5) to 2.9 (0.9) mmol/h (p < 0.05) and from 5.4 (1.3) to 18.7 (2.3) mmol/h (p < 0.01), respectively, with a significant decrease in fasting serum gastrin concentrations, from 127.1 (16.1) to 59.6 (3.8) pg/ml (p < 0.01). The increase in acid secretion after eradication of H pylori was more noticeable in the severe group, who had shown lower acid secretion and higher serum gastrin concentrations (p < 0.05) before eradication, than the increase seen in the moderate group. The decreases in ammonia nitrogen content seen after eradication were significant in basal (from 0.91 (0.17) to 0.37 (0.08) mmol/h, p < 0.05) and stimulated gastric secretions (from 1.57 (0.19) to 0.37 (0.13) mmol/h, p < 0.01), although these changes were too small to explain the increases in basal acid output and maximal acid output. These results suggest that inflammation of the gastric body mucosa caused by H pylori infection is associated with enlarged gastric body folds and inhibition of acid secretion in H pylori positive patients with enlarged gastric body folds.
Polyelectrolyte multilayers functionalized by a synthetic analogue of an anti-inflammatory peptide, α-MSH, for coating a tracheal prosthesis
Authors: Philippe Schultz, Dominique Vautier, Ludovic Richert, Nadia Jessel, Youssef Haikel, Pierre Schaaf, Jean-Claude Voegel, Joelle Ogier, Christian Debry
Journal: Biomaterials (2004)
Measuring Health-Related Quality of Life in Patients With Hepatobiliary Cancers: The Functional Assessment of Cancer Therapy–Hepatobiliary Questionnaire
Authors: Nancy Heffernan, David Cella, Kimberly Webster, Linda Odom, Mary Martone, Steven Passik, Marilyn Bookbinder, Yuman Fong, William Jarnagin, Leslie Blumgart
Journal: Journal of Clinical Oncology (2002)

This is the first report on the development and initial validation of the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) questionnaire, a 45-item self-report instrument designed to measure health-related quality of life (HRQL) in patients with hepatobiliary cancers. The FACT-Hep consists of the 27-item FACT-G, which assesses generic HRQL concerns, and the newly validated 18-item Hepatobiliary Subscale (HS), which assesses disease-specific issues.The development of the HS followed a four-phase process of item generation, item reduction, scale construction, and reliability/validity testing. Two independent samples were studied: item generation (sample 1; n = 30) and reliability/validity testing (sample 2; n = 51).In sample 2, all subscales and aggregated scores showed high internal consistency at initial assessment (Cronbach's alpha range, 0.72 to 0.94) and retesting (Cronbach's alpha range, 0.81 to 0.94). Measurement stability over a 3- to 7-day period was also high for all aggregated scales (test-retest correlation range, 0.84 to 0.91; intraclass correlation coefficient range, 0.82 to 0.90). Convergent and divergent validity were demonstrated by examining relationships between FACT subscales and mood, social support, and social desirability. Finally, when performance status and treatment status were used to divide sample 2, the HS differentiated groups to a degree comparable to the Physical and Functional Well-Being subscales of the FACT-G, thereby contributing favorably to a 32-item Trial Outcome Index. In addition to the 18 validated, scored items in the HS, seven treatment-related items may be appended, if clinically indicated, as a separate subscale.The 45-item FACT-Hep can be used independently as a brief measure of disease-related symptoms and functioning. Alone or paired with the FACT-G, the HS has promise for use in assessing the disease-specific HRQL of patients with hepatobiliary cancers.
Suspension of non-viable fungal spores as a standard for platelet counting.
Authors: R K Archer, M Archer, B V Allen
Journal: BMJ (1977)

In the search among biological particles for a standard for counting human platelets, a strain of Absidia corymbifera was found to have spores that resembled platelets. After fixing in formalin and autoclaving the spores had a similar mean cell volume to that of human platelets. A suspension of these killed spores was tested in 100 laboratories and gave consistent results as a standard for human platelet counting. The Absidia corymbifera standard can be used in electronic counting methods but not in sedimentation methods, as the spores will be removed by centrifugation.
Not everyone agrees with new mammographic screening guidelines designed to end confusion
Authors: A. S. King
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide’s anti-leukemic activity
Authors: P A Spagnuolo, R Hurren, M Gronda, N MacLean, A Datti, A Basheer, F-H Lin, X Wang, J Wrana, A D Schimmer
Journal: Leukemia (2013)
Aspergillus endocarditis in the era of new antifungals: Major role for antigen detection
Authors: Sébastien Rivière, Olivier Lortholary, Jocelyn Michon, Marie-Elisabeth Bougnoux, Jean-Luc Mainardi, Boualem Sendid, Stéphane Bretagne, Agnès Lefort
Journal: Journal of Infection (2013)
Website of the week: Disciplined doctors
Authors: B. Twisselmann
Journal: BMJ (2002)

The Harold Shipman inquiry marks a further shift towards a greater spirit of consumerism. Patients are unlikely to be so trusting ever again. But how can consumers find out whether a practising doctor has violated the law, has been disciplined, or has been struck off for committing a professional offence?

For US consumers at least, the internet makes this fairly easy. The latest online venture in giving access to information about disciplined doctors comes from the group Public Citizen. At www.questionabledoctors.org the group has published a portion of its database of doctors who have been disciplined by state medical boards and federal governments for medical incompetence, misprescribing drugs, sexual misconduct, criminal convictions, ethical lapses, and other offences. Questionable Doctors provides detailed information on some 6700 physicians in California, Connecticut, Hawaii, Illinois, Indiana, Maine, Massachusetts, Michigan, New Hampshire, Ohio, Rhode Island, Texas, and Vermont, and more states will be soon coming online. For a fee, consumers may visit the site to obtain the information they are after. A doctor's name can be searched and sample reports may be accessed before paying the fee. Timely updates of disciplinary information as it becomes available are planned. When all states are available online, patients will be able to cross check their doctor's record nationwide.

Another source of public listings of disciplined doctors in the United States is through state boards of medical examiners (www.advocateweb.org/hope/disciplineddoctors.asp). Or one can try a search engine such as www.google.com using the keywords “  State Medical Board.” This throws up finds such as the New York State Health Department's site on professional misconduct and physician discipline (www.health.state.ny.us/nysdoh/opmc/main.htm). Health Information (www.staticfilter.com/healthinfo.htm) provides links to sites with a variety of useful consumer information, such as how to find the best (but not the worst!) doctor in a particular area.

In the United Kingdom, the General Medical Council (www.gmc-uk.org/) provides a list of registered doctors, albeit with a disclaimer that the absence of a name does not necessarily mean that the doctor is unregistered. Further information can be obtained from the GMC by telephone or email inquiry.
Studies reject aspirin for prevention of pre-eclampsia
Authors: H. Bower
Journal: BMJ (1998)

Three new studies have found that aspirin is of no benefit in preventing pre-eclampsia or in reducing the effects of pre-eclampsia in newborns. But despite the growing body of evidence many doctors continue to use the treatment routinely.

Reporting a randomised trial of 2539 women at high risk of pre-eclampsia, researchers from the National Institute of Child Health and Human Development in the United States said that the findings showed categorically that preventive treatment with aspirin does not work. No significant differences from placebo were found in the women, recruited …
RIGHT VENTRICULAR DYSFUNCTION IN PATIENTS WITH EXERCISE-INDUCED PULMONARY HYPERTENSION ASSOCIATED WITH CONNECTIVE TISSUE DISEASE
Authors: Hirotsugu Yamada, Yoshihito Saijo, Junko Hotchi, Shuji Hayashi, Mika Bando, Susumu Nishio, Yukina Hirata, Takayuki Ise, Shusuke Yagi, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata
Journal: Journal of the American College of Cardiology (2014)
Political diversity will improve social psychological science
Authors: José L. Duarte, Jarret T. Crawford, Charlotta Stern, Jonathan Haidt, Lee Jussim, Philip E. Tetlock
Journal: Behavioral and Brain Sciences (2014)

Abstract Psychologists have demonstrated the value of diversity – particularly diversity of viewpoints – for enhancing creativity, discovery, and problem solving. But one key type of viewpoint diversity is lacking in academic psychology in general and social psychology in particular: political diversity. This article reviews the available evidence and finds support for four claims: (1) Academic psychology once had considerable political diversity, but has lost nearly all of it in the last 50 years. (2) This lack of political diversity can undermine the validity of social psychological science via mechanisms such as the embedding of liberal values into research questions and methods, steering researchers away from important but politically unpalatable research topics, and producing conclusions that mischaracterize liberals and conservatives alike. (3) Increased political diversity would improve social psychological science by reducing the impact of bias mechanisms such as confirmation bias, and by empowering dissenting minorities to improve the quality of the majority's thinking. (4) The underrepresentation of non-liberals in social psychology is most likely due to a combination of self-selection, hostile climate, and discrimination. We close with recommendations for increasing political diversity in social psychology.
Inherited Germline T790M Mutation and Somatic Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Patients
Authors: Carmelo Tibaldi, Elisa Giovannetti, Enrico Vasile, Laura Boldrini, Marielle I. Gallegos-Ruiz, Ilaria Bernardini, Roberto Incensati, Romano Danesi, Federico Cappuzzo, Godefridus J. Peters, Gabriella Fontanini
Journal: Journal of Thoracic Oncology (2011)
THE EFFECT OF AMINO ACIDS ON SERUM AND URINE CREATINE
Authors: Charles M. Grossman
Journal: Journal of Clinical Investigation (1945)

There is now unequivocal evidence that creatine is formed from glycine, arginine, and methionine (1).It is equally well established that creatine can be transformed into creatinine and excreted in this form by the kidneys (2).Creatine is also concerned with the intermediary metabolism of carbohydrate.By a photometric modification of Folin's method, devised by Peters (3), Tierney and Peters (4) demonstrated that the serum of nor- mal men contained measurably significant amounts of creatine.They found that the serum creatine was elevated in patients with hyperthyroidism.Creatinuria was almost invariably associated with concentrations of serum creatine greater than 0.6 mgm.per cent, suggesting that creatine, pre- sumably filtered in the renal glomeruli,. is com- pletely reabsorbed in the tubules when its concen- tration in the serum is less than 0.6 mgm.per cent.The present paper deals with the serum creatine and creatine excretion in various pathological conditions and after certain induced physiological disturbances. METHODS
Squamous Cell Carcinoma of the Skin and Coal Tar Creosote Exposure in a Railroad Worker
Authors: Chris Carlsten, Stephen Carl Hunt, Joel D. Kaufman
Journal: Environmental Health Perspectives (2004)

A 50-year-old male railroad worker presented to his primary care physician with an erythematous, tender skin lesion on the right knee; a biopsy of this lesion revealed squamous cell carcinoma in situ. The site of the lesion was sun-protected but had been associated with 30 years of creosote-soaked clothing. In this article, we review dermal and other malignancies associated with creosote, along with creosote occupational exposures and exposure limits. This is a unique case, given the lack of other, potentially confounding, polyaromatic hydrocarbons and the sun-protected location of the lesion.
Torsades de Pointes
Authors: STEVEN R. LEVINE
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 February 1981Torsades de PointesSTEVEN R. LEVINE, M.D.STEVEN R. LEVINE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-2-276 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Smith and Gallagher (1) cite in their review the patient of Loeb and colleagues (2) as an example of torsade de pointes caused by hypomagnesemia alone. The paper to which they refer describes two patients who presented with ventricular fibrillation associated with hypomagnesemia. The electrocardiogram from Case 1 shows segments of ventricular tachycardia typical of torsade de pointes, but to attribute the arrhythmia to hypomagnesemia alone ignores several other potentially contributing factors. The patient was admitted because of convulsions that followed several weeks of excessive intake of alcohol and malnutrition. Physical examination showed aortic insufficiency. In addition,...References1. SMITHGALLAGHER WJ. "Les torsades de pointes": an unusual ventricular arrhythmia. Ann Intern Med. 1980;93:578-84. LinkGoogle Scholar2. LOEBPIETRASGUNNARTOBIN HRRJ Paroxysmal ventricular fibrillation in two patients with hypomagnesemia. Circulation. 1968;37:210-5. CrossrefGoogle Scholar3. LEVINECROWLEYHAI STH. Hypomagnesemia and ventricular tachycardia: a complication of ulcerative colitis and parenteral hyperalimentation in a nondigitalized noncardiac patient. Chest. In press. Google Scholar1. DESSERTENNE F. La tachycardie ventriculaire a deux foyers opposés variables. Arch Mal Coeur. 1966;59:263-72. MedlineGoogle Scholar2. SMITHGALLAGHER WJ. "Les torsades de pointes": an unusual ventricular arrhythmia. Ann Intern Med. 1980;93:578-84. LinkGoogle Scholar3. Editorial: Englais or Franglish: the case of les torsades de pointes. Ann Intern Med. 1980;93:632-3. LinkGoogle Scholar1. Editorial. Englais or Franglish: the case of les torsades de pointes. Ann Intern Med. 1980;93:632-33. LinkGoogle Scholar2. MARRIOTT H. Workshop in Electrocardiography. Oldsmar, Florida: Tampa Tracings; 1972:228, slide 250. Google Scholar3. SMITHGALLAGHER WJ. "Les torsades de pointes": an unusual ventricular arrhythmia. Ann Intern Med. 1980;93:578-84. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1981Volume 94, Issue 2Page: 276-277KeywordsAlcoholsArrhythmiaConvulsionsElectrocardiographyHypomagnesemiaMalnutritionVentricular fibrillationVentricular tachycardia Issue Published: 1 February 1981 PDF DownloadLoading ...
Oxfam warns countries not to copy Ghana's "flawed" health insurance scheme
Authors: P. Moszynski
Journal: BMJ (2011)

Ghana’s new health insurance scheme benefits far fewer people than is claimed and should not be held up by the World Bank as a model for expanding free universal healthcare in other low and middle income countries, says a new report by Oxfam.

Rather than two thirds of the population being covered by the scheme, as Ghana’s National Health Insurance Authority and the World Bank have claimed, less than a fifth of Ghanaians could be benefiting, the charity says. Its report claims that most people have to continue to pay out of their own pockets for their healthcare.

An Oxfam health policy adviser, Anna Marriott, told the …
Emergency treatment of high blood pressure with oral atenolol.
Authors: L T Bannan, D G Beevers
Journal: BMJ (1981)

Experimental studyRabbits (2-2-5 kg New Zealand white) were treated with sodium warfarin (daily subcutaneous injection), the dosage being adjusted until the BCR was raised to a steady level (at dose 0 40 0O04 mg), after which they were also treated with amiodarone chloride solution (Reckitt and Colman) 35 mg *VITK *VIT K 8CR' 2 (200mg da ily )-.M3krk-:3 -.1.-t 3 4 6 7 8 9 10 nD 1 2 3 4 5 6 7 89 10 ln 12 Days Effect of treatment with amiodarone on British corrected ratio of prothrombin times (BCR).given in daily subcutaneous injections for four days.Venous blood samples (ear vein) were collected in HEPES-buffered trisodium citrate solution for measurement of prothrombin time,' using both human and rabbit brain thromboplastin (Thromboplastin CAHS (UK) Ltd) and derivation of BCR.Results are given as mean I SE and compared by paired Student's t test.The addition of amiodarone resulted in a significant and striking increase in BCR from a stable level of 2 6±0 38 (n~5) before amiodarone, to 5 4±1 4 on day 1, 13 3±440 on day 2, and 6-2±0 59 (n=3, two rabbits having died from gastrointestinal haemorrhage) on day 3, using human thromboplastin; or from 1-9±0 21 to 4 0±111, 9 113-9, and 3 6140 45 respectively, using rabbit thromboplastin. CommentAlthough not yet released for general use in Britain, amiodarone is widely used abroad and under hospital supervision in Britain.It has valuable antiarrhythmic properties2 3 associated with prolongation of action potential duration as well as slowing of action potential upstroke and thus conduction velocity.4The need for special care in using amiodarone in combination with anticoagulant drugs has not been recognised.This case report and experimental study clearly indicate the need for great caution in this respect.The Committee for Safety in Medicine has in fact received some reports suggesting such an interaction (personal communication).Amiodarone is highly (>90%') protein bound in the blood.5A possible explanation of the interaction is therefore that it displaces warfarin from protein-binding sites.Alternatively it could influence warfarin metabolism.This has important therapeutic implications for its clinical use in combination with many drugs.
Chronic lung abscess due to Pasteurella multocida.
Authors: P Machiels, J P Haxhe, J P Trigaux, M Delos, J C Shoevaerdts, O Vandenplas
Journal: Thorax (1995)

Abstract A case of chronic lung abscess due to Pasteurella multocida presenting as a solitary pulmonary mass with a computed tomographic appearance suggestive of malignancy is described.
THE EFFECT OF RADIATION ON THE RESISTANCE OF RABBITS TO INFECTION WITH VIRULENT STAPHYLOCOCCI
Authors: A. Eidinow
Journal: BMJ (1929)

Urbiary Cases in Other Departmnents.1914.M. J., aged 54.Twenty-five year-s in works.Had urinary trouble, anld was sent to Ancoats Hospital and later to the Radium Institute.He died, and at necropsy was found to have had a Xnalignaiit growth of the prostate.1926-27 .K., aged 56.Twenty years' service: metaphenylene- diamine, di-niitro-toluol, benzidine.Had neoplasm of the bladder, and died in 1927.H. was employed at the same place, an-d same service.He also had neoplasm of the bladder and calculus.He died in 1926.'W. had the same twenty years' service as K. Was in hlospital for five weeks in 1919 with acute benzidine toxaeimlia.Died in 1927 witli growvth of the bladder.1922.W. T. was engaged for nearly thirty years in the same service as the last three cases.He complained of pain, and blood was present in the urine.He was admitted to Crumpsall Infirmary, anid died.Pos.it-mnortem examination disclosed lymphosarcoma of the abdomen invading the bladder.N., aged 56, had nearly thirty years' service; at first for some years in the warehouse at the wvorks.He was for ten years on the sulplhuric acid plant; later on metaphenylenediamine.For the last ten years lie was weighing barrels of Iinislhed (dyes.At necropsy he was fouind to have extelnsive growth of the bladder.1924.W. and D., young men of 25 to 30 years of age, of short service; emploved in grinding diphenylguanidine.They had serious urinary pain, btl nlo lhaemorrhages.They left the works, and their Turther history is not known.1924.R. J., aged 42, was employed in the works for five years.He died in Crescent Road Hospital with malignant growth of the bladder.S. w-as employed for many years in drying finislhed dyes in stoves, nmainly of triphenylmethane type.He had dysuria and blood in urine in 1925.Was operated on for papilloma at the Royal Infirmlary.He is still living, but not at work.1926-27 W., a big, 16 st.man of 30.Was employed on niaphtha- lene iiitermlle(liatees-sulplionations, nitrations, and reductions; Had pain, anld bloo(d was present in the urine.He was seen an-d treated by Mr. Macalpine.No neoplasm was found.He i9 now workinig as a. mechanic, and is well.1927. A. lhad dysuria anid blood in uirinie.He was wori orinon cyanide crushing; ino coninexioin established.He is quite well.1928.T., aged 60, has liad fifteeeni years' $service oni azo colounr.He had blood in the urinie and was treated by-his owvn docitol.He is well and st-ill at work.The urine-s of several of the above emplo7ees were anatysro, but yielded nio evidence of toxic, bodies.Non-u-1'inor' (nC's.1920.Incog.; employed oni various produnets; had caircinoma of the caecum.