tbuckley/cabot-search huggingface dataset:
Making Amends misses the point
Authors: Michael Baum
Journal: BMJ (2004)

EDITOR— Making Amends says that NHS staff should inform patients of negligent acts.1 2 The chief medical officer's sweetening of the proposed duty of candour with an exemption from disciplinary action if reporting issues of patient safety is well intentioned but wrong.

Every doctor tries to do his or her best to provide good quality care to his or her patients. As doctors, …
Introduction to Cerebral Angiography
Authors: Samuel M. Wolpert
Journal: JAMA (1981)

While computed tomography has made a major impact in the diagnosis of neurological disease, the need for cerebral angiography, though decreased, remains. Angiography is still of prime importance in the diagnosis of cerebrovascular disease, aneurysms, and arteriovenous malformations. In planning therapy, the neurosurgeon needs to know about the nature of brain tumors and their specific vascular displacements and encasements. This information can be obtained only by cerebral angiography. The topic of this book is therefore appropriate, and the book fulfills a need. At our teaching hospital, the residents, when using the book in conjunction with a busy clinical schedule, found it of considerable benefit in providing the basic reading and knowledge necessary to their work. After an initial chapter in which the technical aspects of cerebral angiography are discussed, the book's structure corresponds with an analysis of specific arteries and veins, rather than disease processes or lesions within specific lobes
Effects of Stepwise Ablation of Chronic Atrial Fibrillation on Atrial Electrical and Mechanical Properties
Authors: Yoshihide Takahashi, Mark D. O’Neill, Méléze Hocini, Patricia Reant, Anders Jonsson, Pierre Jaïs, Prashanthan Sanders, Thomas Rostock, Martin Rotter, Frédéric Sacher, Stephane Laffite, Raymond Roudaut, Jacques Clémenty, Michel Haïssaguerre
Journal: Journal of the American College of Cardiology (2007)
Patients Go Online Seeking Support, Practical Advice on Health Conditions
Authors: Bridget M. Kuehn
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glucagon-like Peptide 1–Based Drugs and Pancreatic Safety—Reply
Authors: Sonal Singh
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Molecular Endocrinology of Hydroxysteroid Dehydrogenases*
Authors: Trevor M. Penning
Journal: Endocrine Reviews (1997)

I. Introduction II. 3β-Hydroxysteroid Dehydrogenase/Ketosteroid Isomerase (3β-HSD/KSI) A. Physiological and pharmacological significance B. Cloning and expression of the 3β-HSD/KSI cDNAs C. Structure, regulation, and tissue-specific expression of the 3β-HSD/KSI genes D. 3β-HSD deficiencies III. 17β-Hydroxysteroid Dehydrogenases A. Physiological and pharmacological significance B. Cloning and expression of the 17β-HSD cDNAs C. Structure, regulation, and tissue-specific expression of the 17β-HSD genes D. 17β-HSD deficiency IV. 11β-Hydroxysteroid Dehydrogenases A. Physiological and pharmacological significance B. Cloning and expression of the 11β-HSD cDNAs C. Structure, regulation, and tissue-specific expression of the 11β-HSD genes D. 11β-HSD deficiency V. 3α-Hydroxysteroid Dehydrogenases A. Physiological and pharmacological significance B. Cloning and expression of the 3α-HSD cDNAs C. Structure, regulation, and tissue-specific expression of the 3α-HSD genes D. 3α-HSD deficiencies VI. 20α-Hydroxysteroid Deh...
Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma
Authors: Noboru Mitsuhashi, Hiroaki Shimizu, Masayuki Ohtsuka, Yasuo Wakabayashi, Hiroshi Ito, Fumio Kimura, Hiroyuki Yoshidome, Atsushi Kato, Yuji Nukui, Masaru Miyazaki
Journal: Hepatology (2003)

Human hepatocellular carcinoma (HCC) is a hypervascular tumor but the mechanisms underlying the process of angiogenesis are not fully understood. Angiopoietins (Ang) have been recently identified as ligands for Tie-2 receptor and are thought to be important factors in vascular maturation and stability during angiogenesis. In this study, we investigated the expression of Ang-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) in surgically resected specimens from 46 patients with HCC to determine their potential role in tumor angiogenesis and its progression. VEGF messenger RNA (mRNA) was significantly up-regulated in HCC compared to normal liver tissue from patients with hepatic metastases. No differences were found between HCC and adjacent liver tissue. Meanwhile, Ang-2 mRNA expression in HCC was significantly increased when compared to adjacent liver tissue. On the other hand, Ang-1 and Tie-2 mRNA expression in HCC was not different from that in adjacent liver tissue. Immunohistochemical staining also showed increased Ang-2 protein in HCC. Furthermore, a high Ang-2/1 mRNA ratio in HCC was closely associated with tumor portal vein invasion, tumor diameter, and the microvessel density level as assessed by CD34 immunostaining. With regard to prognosis, the survival time for patients in the high Ang-2/1 mRNA ratio group was significantly poorer when compared with the low Ang-2/1 mRNA ratio group. In conclusion, an increased expression of Ang-2/1 in the presence of VEGF may play a critical role in promoting tumor angiogenesis and progression in human HCC.
Chemotherapeutic Failure: Resistance or Insensitivity?
Authors: Albert S. Braverman
Journal: Annals of Internal Medicine (1993)

Immunocyte and germ cell neoplasms, often curable by chemotherapy, arise from normal tissues most vulnerable to the effects of cytotoxic drugs; generalizing from these results to treating other tumors with such agents may not be entirely valid. Our limited success in treating epithelial neoplasms may be due to insensitivity rather than to drug resistance. Well-designed attempts to overcome resistance have been unsuccessful. The acquired immunodeficiency syndrome has not confirmed the putative role of immune surveillance in the pathogenesis of most neoplasms. The limited success of the most elaborate immunotherapies suggests that they, too, are nonspecific cell-killing techniques. Immunologic and cytotoxic drug therapies deserve further investigation but on a smaller scale.Neoplastic cell molecular biology, unknown when these therapies were developed, is being rapidly elucidated and may make it possible to treat malignancies by modulating cell physiology. Success of therapies based on the advances, in molecular biology, is not more uncertain than that of traditional treatments. Differentiation-induction techniques have already induced remissions in patients with acute promyelocytic leukemia and squamous cell carcinomas.
Long-Acting Methods of Contraception
Authors: Herbert B. Peterson, Kathryn M. Curtis
Journal: New England Journal of Medicine (2005)

A healthy, multiparous 23-year-old woman requests advice about contraception. Her last child was conceived while she was using oral contraceptives, which she took irregularly. She wants no more children and desires a highly effective and long-acting method of contraception. She is sexually active in a monogamous relationship and was treated for gonococcal cervicitis at the age of 16 years. She has normal menses. Findings on pelvic examination are normal. What contraceptive methods are appropriate for her?
Temporal Phases of Activity-Dependent Plasticity and Memory Are Mediated by Compartmentalized Routing of MAPK Signaling in Aplysia Sensory Neurons
Authors: Justin L. Shobe, Yali Zhao, Shara Stough, Xiaojing Ye, Vickie Hsuan, Kelsey C. Martin, Thomas J. Carew
Journal: Neuron (2009)
GAS NEUROSIS SYNDROME
Authors: HAROLD S. HULBERT
Journal: American Journal of Psychiatry (1920)

1. Gas neurosis syndrome is similar to the non-concussion type of so-called "shell shock" or war neurosis, and is found in those who have been exposed to gas warfare. 2. The symptoms of this functional neurosis are various degrees of physical movements related to altered or increased respiration, anxiety, altered consciousness and involuntary motor movements. If the disorder is clearly recognized and correctly diagnosed, early and suitable treatment will cause recovery. 3. Its severity is not in proportion to the organic damage from being gassed, but is in proportion to the make-up and military maladjustment of the individuals affected. 4. Pathological emphasis on gas warfare in the training of soldiers and in popular education of civil communities, as well as inadequate military mental hygiene of those participating in warfare, exaggerates the idea of risk, makes the soldiers discontented, and predisposes them to incapacitating neuroses.
Colour word trouble
Authors: B. A. C. Saunders, J. van Brakel
Journal: Behavioral and Brain Sciences (1999)

In reply to Wierzbicka's advocacy of semantic primitives we argue that talk of the semantic primitives (like to see ) repeats the fallacies addressed in the target article at a higher level. In reply to Malcolm's plea for a Wittgensteinian grammar of colour words, we argue that he uses words like “we” and “us” too easily, falling into the trap of “silly relativism.” In reply to McManus's science of word counts, we reiterate the nineteenth-century criticism that this method is based on an illegitimate application of seemingly rigorous statistical methods.
NHS reorganisations: who's kicking whom, who's protesting?: More patient choice with less doctor choice is bad for everybody
Authors: Amit Patel
Journal: BMJ (2006)

EDITOR—Hawkes provides a clear account of the barrage of politically motivated changes the NHS in England has ever had to endure.1 This outstanding article cuts through political correctness, pointing out the true motivations for recent government policy—money, power, and control.

The rushed implementation of proposed …
Testing for BRCA1 in Hereditary Breast Cancer-Reply
Authors: Timothy J. Triche
Journal: JAMA (1995)

<h3>In Reply.</h3> —OncorMed provides service for the early detection and treatment of cancer through molecular genetics. This service is provided through physicians, geneticists, and genetic counselors. We share Dr Vance's concerns that the public be educated as to the risks, benefits, advantages, and current limitations of genetic testing. Our marketing material, which is available to physicians and genetic counselors, reflects this concern. We agree with Vance that commercial companies should not be immune to technical and ethical responsibilities involved in genetic testing. All of the physicians and scientists at OncorMed come from academic backgrounds and retain academic affiliations. We work with physicians, bioethicists, medical geneticists, and patient advocates to assure that our services meet the highest standards of quality and integrity. We regret that Vance interprets our position otherwise or that any of our company information would create a difficulty for her or her associates in what is already a
UK strategy to help increase clean water supplies worldwide
Authors: R. MacDonald
Journal: BMJ (2001)

One billion of the world's people have only dirty water to drink, and a third lack sanitation, a recent report from the Department for International Development has said, supporting the provision of clean water as a fundamental right for all.

Its strategy paper Addressing the Water Crisis is Britain's response to the United Nations' development targets of halving by the year 2015 the proportion of people who have no access to clean water or hygienic sanitation.

The paper has spelt out the health risks from dirty water. Water related diseases, such as cholera, typhoid, dysentry, …
A randomised trial of three methods of giving information about prenatal testing
Authors: J G Thornton, J Hewison, R J Lilford, A Vail
Journal: BMJ (1995)

<h3>Abstrac</h3> <b>Objective</b>: To test the effect of extra non-directive information about prenatal testing, given individually or in a class. <b>Setting</b>: Antenatal clinics in a district general hospital and a university hospital. <b>Design</b>: Randomised controlled trial; participants allocated to control group or offer of extra information individually or in class. <b>Subjects</b>: 1691 women booking antenatal care before 15 weeks9 gestation. <b>Interventions</b>: All participants received the usual information about prenatal tests from hospital staff. Individual participants were offered a separate session with a research midwife in which prenatal screening was described in detail. Class participants were offered the same extra information in an early prenatal class. <b>Main outcome measures</b>: Attendance at extra information sessions; uptake rates of prenatal tests; levels of anxiety, understanding, and satisfaction with decisions. <b>Results</b>: Attendance at classes was lower than at individual sessions (adjusted odds ratio 0.45; 95% confidence interval 0.35 to 0.58). Ultrasonography was almost universally accepted (99%) and was not affected by either intervention. Uptake of cystic fibrosis testing, high in controls (79%), was lowered in the individual group (0.44; 0.20 to 0.97) and classes (0.39; 0.18 to 0.86). Uptake of screening for Down9s syndrome, already low (34%) in controls, was not further depressed by extra information in classes (0.99; 0.70 to 1.39) and was slightly higher in the individual group (1.45; 1.04 to 2.02). Women offered extra information had improved understanding and were more satisfied with information received; satisfaction with decisions about prenatal testing was unchanged. The offer of individual information reduced anxiety later in pregnancy. <b>Conclusions</b>: Ultrasonography is valued for non-medical reasons and chosen even by fully informed people who eschew prenatal diagnosis. The offer of extra information has no overall adverse effects on anxiety and reduces uptake of blood tests when background uptake rate is high (but not when it is already low). High uptake of prenatal blood tests suggests compliant behaviour and need for more information.
PREDICTING INDIVIDUAL DIFFERENCES IN PAIN AND FUNCTIONAL IMPAIRMENT AMONG PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: Kristofer J. Hagglund, William E. Haley, John D. Reveille, Graciela S. Alarcón
Journal: Arthritis & Rheumatology (1989)

Objective measures of disease activity (erythrocyte sedimentation rate and joint swelling), disease severity (radiographic ratings), and psychological variables (coping strategies and affective states) were used to predict the degree of pain and functional impairment that would be experienced by a group of 53 patients who had rheumatoid arthritis. The severity of disease demonstrated no significant relationship to measures of outcome. Multiple regression analyses revealed that psychological variables explained a substantial proportion of the variance in outcome scores, even after disease activity was taken into account. Our study highlights the discrepancies between biomedical measures of disease severity and activity and patient outcome in a rheumatoid arthritis population, and our observations suggest that some of these discrepancies may be explained by psychological variables.
The talisman effect
Authors: C. Ellis
Journal: BMJ (2010)

Early most mornings I shuffle into the kitchen to make coffee for the family. You may visualise the cupboard in our kitchen above the counter to my right. This is where the family’s store of vitamins is kept. There are numerous bottles of vitamins and minerals labelled from A all the way to Z. There is vitamin C and lots of vitamin Bs and then a whole lot of minerals such as zinc and magnesium and even selenium. Our …
Die Beziehung zwischen der psychotherapeutischen Technik und der Theorie der Psychotherapie
Authors: Johannes Cremerius
Journal: Psychotherapy and Psychosomatics (1974)

Beginning with the question: If one can manage even without a theoretical frame of reference, I shall discuss the necessity of a theoretical background for therapeutic activity. I shall next discuss the question: On which theory should we stand? Ultimately I shall examine the relationship between theory and technique, its advantages and risks. I shall give special concern to the question: What becomes of Man? (Both therapist and patient) in therapies conducted on a one-sided theoretically founded technique. A specific example – namely the transaction between therapist and patient concerning the aim of treatment, makes clear the imminent political implications resulting from a theoretically determined technique.
Powerless Groups—A Vector in Mental Health Education
Authors: RALPH CRAWSHAW
Journal: American Journal of Psychiatry (1969)

Because of the power orientation in the mental health education system, student compassion or emotional involvement with the patient, the student's most valuable asset, is often neglected in the struggle for grades. To help develop compassion in the student or professional, the author proposes formation of "powerless groups"—groups with common interests but no institutional responsibilities. Three such groups are examined.
Richard Alan Cobb
Authors: Carol Cobb
Journal: BMJ (2004)

Consultant surgeon Birmingham Heartlands and Solihull NHS Trust 1993-2004, honorary senior lecturer University of Birmingham, and honorary consultant surgeon Birmingham Children's Hospital (b Plymouth 1953; q St Thomas' Hospital Medical School, London, 1978; FRCS, MS), died from metastatic melanoma on 13 June 2004.

Richard trained in Derby, Southampton, Salisbury, Reading, Hammersmith, and Oxford. He was a past president of the Association of Surgeons in Training, and sat on the council of the Royal College of Surgeons of England and the Association of Coloproctology of Great Britain and Ireland. He was also a lieutenant in the Light Infantry, a fisherman, a sailor, a bread maker, a gardener, and a bridge player. He leaves a wife, Carol, and three children.
393 CHANGING OF GENOTYPES AND MOLECULAR EPIDEMIOLOGY OF SPREADING SUBGENOTYPE AE OF HEPATITIS B VIRUS AMONG PATIENTS WITH ACUTE HEPATITIS B IN JAPAN
Authors: Y. Tamada, H. Yatsuhashi, K. Yano, M. Nakamuta, N. Masaki, E. Mita, T. Komatsu, Y. Watanabe, T. Muro, M. Shimada, T. Hijioka, T. Sato, A. Komori, S. Abiru, K. Migita, M. Nakamura, H. Fujioka, H. Ishibashi
Journal: Journal of Hepatology (2011)
Treatment of Oral Ulceration
Authors: Peter Ashurt
Journal: British Journal of Dermatology (1968)

Journal Article Treatment of Oral Ulceration Get access Peter Ashurt Peter Ashurt Manchester and Salford Hospital for Skin Diseases, Quay Street, Manchester, 3 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 2, 1 February 1968, Page 124, https://doi.org/10.1111/j.1365-2133.1968.tb12276.x Published: 01 February 1968
Oral Contraceptives and Chlamydia Infections
Authors: Stanley A. Gall
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Before conclusions are drawn that oral contraceptives (OCs) do not protect against pelvic infections (PID) caused by<i>Chlamydia trachomatis</i>,<sup>1</sup>a somewhat more critical examination of the literature may be in order. The highest incidence of chlamydial infection has been shown to occur in women younger than 25 years<sup>2,3</sup>; the highest percentage of women using OCs is also in this age group.<sup>3,4</sup>Chlamydial infection is more common in single and divorced women than in married women,<sup>2,3,5</sup>in women whose partners have experienced recent nonspecific urethritis,<sup>5</sup>and is also associated with having more than one sex partner<sup>2</sup>and with nulliparity.<sup>2,3</sup> There is no correction for the effects of these apparent risk factors in any of the case-control studies cited by Washington et al<sup>1</sup>in which OC use has been associated with increased incidence of chlamydial infection. It is difficult to know
Endocrine Control of Body Composition in Infancy, Childhood, and Puberty
Authors: Johannes D. Veldhuis, James N. Roemmich, Erick J. Richmond, Alan D. Rogol, Jennifer C. Lovejoy, Melinda Sheffield-Moore, Nelly Mauras, Cyril Y. Bowers
Journal: Endocrine Reviews (2004)

Body composition exhibits marked variations across the early human lifetime. The precise physiological mechanisms that drive such developmental adaptations are difficult to establish. This clinical challenge reflects an array of potentially confounding factors, such as marked intersubject differences in tissue compartments; the incremental nature of longitudinal intrasubject variations in body composition; technical limitations in quantitating the unobserved mass of mineral, fat, water, and muscle ad seriatim; and the multifold contributions of genetic, dietary, environmental, hormonal, nutritional, and behavioral signals to physical and sexual maturation. From an endocrine perspective (reviewed here), gonadal sex steroids and GH/IGF-I constitute prime determinants of evolving body composition. The present critical review examines hormonal regulation of body composition in infancy, childhood, and puberty.
590 MICRO-RNA PROFILING IN HUMAN SERUM REVEALS ETIOLOGY-INDEPENDENT, COMPARTMENT-SPECIFIC ROLES OF MIR-571 AND MIR-652 IN LIVER CIRRHOSIS
Authors: C. Roderburg, D. Vargas Cardenas, M. Vucur, C. Trautwein, F. Tacke, T. Luedde
Journal: Journal of Hepatology (2012)