Treatment of Cyclosporine-Induced Gingival Hypertrophy
Authors: Emanuela Cecchin
Journal: Annals of Internal Medicine (1997)

Letters1 March 1997Treatment of Cyclosporine-Induced Gingival HypertrophyEmanuela Cecchin, MD, Fabrizia Zanello, MD, and Sergio De Marchi, MDEmanuela Cecchin, MDUniversity of Udine Medical School, 33100 Udine, Italy, Fabrizia Zanello, MDUniversity of Udine Medical School, 33100 Udine, Italy, and Sergio De Marchi, MDUniversity of Udine Medical School, 33100 Udine, ItalyAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-5-199703010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Gingival hypertrophy is a complication of cyclosporine therapy that affects one fourth to one third of patients receiving renal or cardiac transplants who receive traditional therapy [1]. The incidence of this adverse effect is lower with the new formulation of cyclosporine, which is based on a microemulsion technology [2]. The improvement of cyclosporine-associated gingival hypertrophy has been reported with metronidazole in transplant recipients [3, 4]. Cyclosporine is effective in the treatment of rheumatoid arthritis, but little is known about the prevalence of gingival hypertrophy and the treatment of this condition in patients with rheumatoid arthritis.A 40-year-old ...References1. Pernu HE, Pernu LM, Knuuttilia ML, Huttunen KR. Gingival overgrowth among renal transplant recipients and uraemic patients. Nephrol Dial Transplant. 1993; 8:1254-8. Google Scholar2. Milanes CL, Arminio A, Barrios Y, Garcia-Ramirez R, Herrera J, Leon I, et al. Safety in the switching traditional cyclosporin to microemulsion cyclosporin in stable renal transplant patients: cooperative study. Invest Clin. 1995; 36:183-96. Google Scholar3. Wong W, Hodge MG, Lewis A, Sharpstone P, Kingswood JC. Resolution of cyclosporin-induced gingival hypertrophy with metronidazole. Lancet. 1994; 343:986. Google Scholar4. Seymour HR, Goldsmith D, Sharpstone PS, Kingswood JC. Treatment of cyclosporin-induced gum hypertrophy. Nephrol Dial Transplant. 1996; 11:1434. Google Scholar5. Yamazaki K, Nakajima T, Hara K. Immunohistological analysis of T cell functional subsets in chronic inflammatory periodontal disease. Clin Exp Immunol. 1995; 99:384-91. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Udine Medical School, 33100 Udine, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMiscellaneous Drug-related Adverse EffectsTrial of metronidazole vs. azithromycin for treatment of cyclosporine-induced gingival overgrowthGastrointestinal side effects of drugsPathologic Quiz Case: Post–Lung Transplantation Patient With Bilateral Breast MassesDrug-Induced Gingival Hyperplasia in Transplant RecipientsPrevalence and Risk of Gingival Enlargement in Patients Treated With NifedipineMedically Induced Gingival HyperplasiaMedically Induced Gingival Hyperplasia: In ResponseCyclosporin 1 March 1997Volume 126, Issue 5Page: 409-410KeywordsCardiac transplantationCreatinineGram negative bacteriaImmune responseLymphocytesPathogenesisPeriodontal diseasesRenal transplantationRheumatoid arthritisSigns and symptoms Issue Published: 1 March 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...