tbuckley/cabot-search huggingface dataset:
Can Primary Care Physician–Driven Community Programs Address the Obesity Epidemic Among High-Risk Populations?
Authors: Regina M. Benjamin, Susan Z. Yanovski, Denise G. Simons-Morton
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Multiple Bronchostenoses due to Sarcoidosis
Authors: M. Honey, E. Jepson
Journal: BMJ (1957)

<h3>ABSTRACT</h3> SARS-CoV-2, the causative agent of the ongoing COVID-19, has spread worldwide since it was first identified in November 2019 in Wuhan. Since then, it was already demonstrated an exuberant inflammation, cytokine storm, endothelium dysfunction, platelets hyperactivation and aggregation, following T cell exhaustion leading to severe multi-organ damage and death of COVID-19 patients. Here, we sought to identify molecular biomarkers of disease severity in a Brazilian cohort of COVID-19 patients by measuring the serum levels of endogenous danger signals. Our data revealed that ICU patients that are critically ill, at the early hyperinflammatory phase of COVID-19 (around 12-25 days after hospital admission) display higher serum levels of the classical alarmin HMGB1. Serum levels of HMGB1 were positively correlated with cys-leukotrienes, D-dimer, AST, and ALT. Notably, we verified that HMGB1 levels above 125.4 ng/mL is the cut off that distinguishes the patients that are at higher risk of death. Serum levels of extracellular ATP, PGE<sub>2</sub>, LTB<sub>4</sub>, cys-LTs, and tissue factor were also elevated in the serum of ICU patients. In conclusion, we propose that serum levels of HMGB1 serve as prognostic biomarker of risk of death in patients suffering from severe COVID-19.
Intravitreal therapy for neovascular age-related macular degeneration and inter-individual variations in vitreous pharmacokinetics
Authors: Augustinus Laude, Lay Ean Tan, Clive G. Wilson, Gerassimos Lascaratos, Mohammed Elashry, Tariq Aslam, Niall Patton, Baljean Dhillon
Journal: Progress in Retinal and Eye Research (2010)
The gatekeeper and the wizard, redux
Authors: D. Kamerow
Journal: BMJ (2009)

An Old World fable exported to America (with apologies and homage to Nigel Mathers1 2 3)

Once upon a time, in a country far away, lived a great wizard with wondrous healing powers. He lived in a splendid castle on a hill overlooking the city. The wizard was clever. He knew how to use magic crystals to see inside people to find out what was wrong with them, and he had magic spells and potions to treat their illnesses. When sick people came to see the wizard, he often cured them or made them feel better and live longer. For his work he was paid handsomely.

Down the hill, in a nice big house, though not as grand as the wizard’s, lived a gatekeeper. An important part of her job was to decide who got to see the wizard. She was also clever, and she had magic potions as well. After …
THROMBOEMBOLIC COMPLICATIONS AND HAEMOSTATIC CHANGES IN CYCLOSPORIN-TREATED CADAVERIC KIDNEY ALLOGRAFT RECIPIENTS
Authors: Y Vanrenterghem, T Lerut, L Roels, J Gruwez, P Michielsen, P Gresele, M Colucci, H Deckmyn, J Arnout, J Vermylen
Journal: The Lancet (1985)
Fluorescein-enhanced Autofluorescence Thoracoscopy in Primary Spontaneous Pneumothorax
Authors: Marc Noppen, Grigoris Stratakos, Sylvia Verbanck, Jan D'Haese, Marc Meysman, Walter Vincken
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

The exact site of air leakage in a patient with primary spontaneous pneumothorax is difficult to determine and locate. In particular, the role of rupture of emphysema-like changes (blebs and bullae) versus that of enhanced porosity of lung parenchyma in the pathophysiology of primary spontaneous pneumothorax remains unclear. This is the first description of a patient with recurrent primary spontaneous pneumothorax in whom inhalation of aerosolized fluorescein followed by autofluorescence thoracoscopy allowed in vivo localization of various lung areas of extensive subpleural fluorescein accumulation which were not, or only partly, visibly abnormal during normal white light thoracoscopy. No air leak was present at the time of thoracoscopy. No emphysema-like changes were seen. Our findings suggest substantial areas of parenchymal abnormality that remain unnoticed by white light thoracoscopic inspection of the parenchymal surface. In this respect, fluorescein-enhanced autofluorescence thoracoscopy may become an exciting tool in the study of the pathophysiology of primary spontaneous pneumothorax, and could prove useful in clinical practice in determining the sites of surgical staple resection whenever this treatment modality is considered.
Long-term follow-up of high-dose treatment with autologous haematopoietic progenitor cell support in 693 patients with follicular lymphoma: an EBMT registry study
Authors: S Montoto, C Canals, A Z S Rohatiner, G Taghipour, A Sureda, N Schmitz, C Gisselbrecht, L Fouillard, N Milpied, C Haioun, S Slavin, E Conde, C Fruchart, A Ferrant, V Leblond, H Tilly, T A Lister, A H Goldstone
Journal: Leukemia (2007)
Wessex cardiac surgery follow-up survey: the quality of life after operation
Authors: J. K. Ross, A. E. Diwell, J. Marsh, J. L. Monro, D. J. P. Barker
Journal: Thorax (1978)

Differential images of ocular dominance, acquired by comparing responses to the two eyes, reveal dark and light bands where cortical cells are dominated by the right and left eyes. These include most (but not all) histochemically stained cytochrome oxidase blobs in their centers. Differential images of orientation, acquired by comparing responses to orthogonal orientations, reveal dark and light bands that are reminiscent of the "orientation columns" reported earlier, on the basis of 2-deoxyglucose (2DG) autoradiograms (Hubel et al., 1978). However, they are shorter and more fragmented because they do not include regions lacking selectivity for orientation. Even though these "bands" derive from orientation-selective areas, comparisons with differential images of other orientations reveal that regions along their centers prefer different orientations. Hence, the orientation preferences inferred from "bands" in single differential images, or single 2DG autoradiograms, are not necessarily incorrect. Interactions between ocular dominance and orientation were investigated by comparing differential images of orientation obtained with binocular and monocular stimulation, as well as by comparing differential images of ocular dominance obtained with different orientations. In both cases, the elicited interactions were minimal, indicating a remarkable and unexpected independence that subsequent experiments revealed arises, at least in part, from a lateral segregation of regions most selective for one eye and regions most selective for one orientation, in the centers and edges of ocular dominance columns. Since this can also be viewed as a lateral correlation between binocularity and orientation selectivity, it fits with the simultaneous emergence of these properties in layers receiving input from layer 4c, and suggests that each of these properties requires the other.
Antibiotic Prophylaxis of Infectious Complications with Endoscopic Retrograde Cholangiopancreatography. A Randomized Controlled Study
Authors: G. Sauter, B. Grabein, G. Huber, G. A. Mannes, G. Ruckdeschel, T. Sauerbruch
Journal: Endoscopy (1990)

Biliary sepsis represents a major percentage of fatal complications after endoscopic retrograde cholangiopancreatography. We performed a randomized controlled study to investigate the value of antibiotic prophylaxis, and to assess the frequency and source of infectious complications associated with ERCP. Ninety-six patients who underwent 100 endoscopic retrograde cholangiopancreatographies were included in the study. Half of the patients received antibiotic prophylaxis (Cefotaxime 2 g i.v. 15 min before the procedure). Bacteremia was detected in 2% of the patients receiving antibiotic prophylaxis, as compared with 16% (p less than 0.02) in the control group. In order to determine the source of bacteremia, bile samples and irrigation fluid from the suction channel of the endo-scope were obtained for bacteriological evaluation. Several lines of evidence suggested that bacteremia associated with ERCP was essentially caused by mucosal lesions of the oropharynx. Bacteremia was asymptomatic, with the exception of two patients who subsequently developed fever, but recovered rapidly under antibiotic therapy. The frequency of cholangitis following ERCP was not significantly reduced by antibiotic prophylaxis (4% vs. 2%). Recommendations for antibiotic prophylaxis are discussed.
CONSERVATIVE SURGERY OF THE PELVIC ORGANS AND THE LOWER ABDOMINAL WALL
Authors: FLOYD W. McRAE
Journal: JAMA (1910)

It is not my purpose to attempt to present anything new, but rather to discuss end-results in pelvic surgery from the viewpoint of a practical man who has kept in exceptionally close touch with his cases, prior to and following surgical operations. For fourteen years I did a very active general practice with a constantly increasing surgical element. For ten years now, I have limited my work to surgery and surgical consultations. I reside within 200 miles of where I was born in a community of Scotch settlers as clannish as native Scots; I am of Scotch extraction, a member of perhaps the most prolific and ramifying family of all those Scotch pioneers. A great deal of my surgery has been done on these relatives and life-time friends, thus enabling me to follow up my cases. Atlanta has been the field of my professional activities, her population nearly trebling during
TCTAP A-200 The Diffuse and Multi-vessel Coronary Artery Spasm Increase the Incidence of Recurrent Chest Pain During 3-year Clinical Follow up
Authors: Sang-Ho Park, Seung-Woon Rha, Won-Yong Shin, Dong-Kyu Jin, Byoung Geol Choi, Se Yeon Choi, Yoonjee Park, Akkala Raghavender Goud Hu Li, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
The Price of Alcohol
Authors: Robert C. Brook
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The Sept 19,1986, issue of<i>JAMA</i>included several excellent articles related to alcohol abuse and alcoholism. Your continuing effort to educate health professionals on one of our most serious health problems is much appreciated. However, I want to comment on a subject that was not discussed: the relationship between the retail price of alcohol and alcohol-related problems. Over the past several decades, the retail prices of alcoholic beverages in the United States have declined compared with disposable income and the prices of other consumer goods, including alternative beverages such as soft drinks. An important reason for this decline is that federal alcohol excise taxes and many state alcohol taxes are flat taxes that have lagged well behind inflation. Retail price is a powerful influence on population-wide alcohol consumption. Low prices stimulate higher levels of consumption. Higher levels of consumption are, in turn, associated with higher levels of
Adrenocortical Steroids and Tuberculosis
Authors: Irvin M. Golding, William Lester, George S. Berg
Journal: New England Journal of Medicine (1956)

RECENT widespread use of the adrenocortical substances has resulted in many optimistic reports regarding their efficacy and clinical applicability. The number of diseases for which these drugs are being given is increasing steadily, and the list of patients who are given courses of treatment with these potent agents is growing daily. Several new products and their derivatives demonstrate greater potency per milligram and are less likely to create electrolyte imbalances. There has been, however, no gross change in the other pharmacologic effects of such drugs. They exert an influence on carbohydrate metabolism, reduce inflammatory reactions, keep fever and its toxic . . .
67 LIVER CELL-SPECIFIC PPARg CONDITIONAL-NULL MICE ESTABLISH ANTI-INFLAMMATORY AND ANTI-FIBROGENIC PROPERTIES FOR THIS NUCLEAR RECEPTOR IN KUPFFER CELLS
Authors: E. Morán-Salvador, E. Titos, A. González-Périz, B. Rius, V. García-Alonso, C. López-Vicario, R. Miquel, Y. Barak, V. Arroyo, J. Claria
Journal: Journal of Hepatology (2012)
Transesophageal Echocardiography in High-Risk Patients with Atrial Fibrillation
Authors: Kwan-Leung Chan
Journal: Annals of Internal Medicine (1998)

Letters1 November 1998Transesophageal Echocardiography in High-Risk Patients with Atrial FibrillationKwan-Leung Chan, MD and Jonathan L. Halperin, MDKwan-Leung Chan, MDUniversity of Ottawa Heart Institute; Ottawa, Ontario K1Y 4E9, CanadaMount Sinai Medical Center; New York, NY 10029Search for more papers by this author and Jonathan L. Halperin, MDUniversity of Ottawa Heart Institute; Ottawa, Ontario K1Y 4E9, CanadaMount Sinai Medical Center; New York, NY 10029Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-9-199811010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the cogent comments of Drs. Tunick and Kronzon. Thoracic aortic plaque is associated with a high risk for stroke, both in patients with [1] and without [2, 3] atrial fibrillation. The magnitude of risk has been measured only within broad confidence limits, however, and seems to persist despite antithrombotic therapy with a low-intensity combination of warfarin and aspirin in patients with coexisting atrial fibrillation. The reduction in stroke among patients treated with higher-intensity anticoagulation with adjusted-dose warfarin may have been due to disappearance of thrombus in the left atrial appendage. This phenomenon, previously described in selected ...References1. Zabalgoitia M, Halperin JL, Pearce LA, Blackshear JL, Asinger RW, Hart RG. Transesophageal echocardiographic correlates of clinical risk of thromboembolism in nonvalvular atrial fibrillation. J Am Coll Cardiol. 1998; 31:1622-6. Google Scholar2. Amarenco P, Cohen A. Atherosclerotic disease of the aortic arch as a risk factor for recurrent ischemic stroke. N Engl J Med. 1996; 334:1216-21. Google Scholar3. Tunick PA, Rosenzweig BP, Katz ES, Freedberg RS, Perez JL, Kronzon I. High risk for vascular events in patients with protruding aortic atheromas: a prospective study. J Am Coll Cardiol. 1996; 23:1085-90. Google Scholar4. Collins LJ, Silverman DI, Douglas PS, Manning WJ. Cardioversion of nonrheumatic atrial fibrillation. Circulation. 1995; 92:160-3. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Ottawa Heart Institute; Ottawa, Ontario K1Y 4E9, CanadaMount Sinai Medical Center; New York, NY 10029 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1998Volume 129, Issue 9Page: 748KeywordsAortaAtrial fibrillationClinical trialsEchocardiographyForecastingLesionsStrokeThromboembolismThrombosisVascular diseases Issue Published: 1 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Finding of Right Hepatic Vein Focal Defect in Liver Scan of a Patient With Veno-Occlusive Disease
Authors: SUSUMU SHIOMI, TETSUO KUROKI, TAKUYA KITADA, SHINYA NAKAJIMA, KENZO KOBAYASHI, HIRONOBU OCHI
Journal: Clinical Nuclear Medicine (1993)

A 38-year-old woman hospitalized for delivery after treatment for infertility with lymphocyte transfusions from her husband developed severe hepatopathy. On the basis of findings in a hepatic specimen obtained by biopsy, the authors diagnosed hepatic veno-occlusive disease. In scintigrams that used Tc-99m phytate, a long, narrow defect was found that extended from the outer part of the right lobe of the liver to the junction of the hepatic veins and the inferior vena cava. In SPECT of the liver performed with Tc-99m phytate, the defect corresponded to the region of the right hepatic vein.
Thermography in assessing coronary artery saphenous graft patency and blood flow
Authors: F P SHABBO, G M REES
Journal: Cardiovascular Research (1982)

Infrared thermography has been used in 32 patients undergoing coronary artery saphenous bypass graft surgery in our department, in order to visualise graft patency and flow at the time of surgery. 16 of these patients also had flow measurements with the use of electromagnetic flow meters to one or more of their grafts, which had already been thermographed in order to establish a correlation between the two methods. This study has confirmed that grafts which show good flow by means of electromagnetic flow meters also have a good pictorial graft patency and flow with infrared thermography.
Type 1 Diabetes Is Not Associated With Increased Central Abdominal Obesity
Authors: Jerry R. Greenfield, Katherine Samaras, Lesley V. Campbell, Donald J. Chisholm
Journal: Diabetes Care (2003)

We read with interest the recent editorial by Sobel (1), wherein it is asserted that “intensive treatment of type 1 diabetes appears to increase central obesity.” We agree with Sobel that “the insulin resistance underlying type 2 diabetes and frequently manifested in those with type 1 diabetes may be the most powerful determinant of coronary disease” (1), but argue that insulin resistance in type 1 diabetes is unrelated to increased central abdominal adiposity.

Attention should be directed to our recent …
The Internist's Library
Authors: T. Mark Hodges
Journal: JAMA (1973)

To the Editor.—  I will not venture an interpretation of the recommendation of the American College of Physicians (226:352, 1973) any more than I will get embroiled in listsmanship (the art of compiling and defending lists of recommended works).  I would like to say, however, that if the cost of a personal library for the internist, or any health practitioner, is the inhibiting factor, then might not a small, regular contribution toward the support (or establishment of a local health-science library be a sensible alternative? This would provide reasonable assurance that books and journals would be available when needed.  Existing health-science libraries of all kinds are hard-pressed by rising costs, while many communities in the nation lack even a modicum of local medical library service.
PTH-063 Is Evening Endoscopy Cost Effective?
Authors: P Closier, C Hollywood
Journal: Gut (2014)

<h3>Introduction</h3> Currently in the UK we are seeing an increasing demand for endoscopy services that is set to continue to rise over the coming years.<sup>1</sup> Our aim as an endoscopy department is to deliver a patient focused service, and patient choice is an integral component of this. The option of evening endoscopy lists is a novel approach to widening patient choice for provided services whilst simultaneously working towards a 7 day working week. Our aim was to evaluate the success of evening lists in terms of attendance and endoscopic outcomes to ensure the most cost effective evening service whilst identifying potential areas for development. <h3>Methods</h3> We analysed data for scheduled evening endoscopy sessions (18.00 to 21.00) booked at Gloucestershire Royal Hospital over a 3 month period from April 2013. Information about pre-endoscopy fast, endoscopic results and non-attendance (DNA) rates was processed. <h3>Results</h3> 54 patients were listed for endoscopy, of these 18 (33%) endoscopies were inconclusive; 6 (35%) abandoned due to food bolus, with 9 (53%) non-attenders. Food bolus patients had fasting times between 6–8 h (as per protocol), but all had taken a substantial meal pre-fasting and 50% were diabetic. All non-attenders were booked for variceal surveillance. <h3>Conclusion</h3> Developing evening services is essential to meet user needs; however more guidance is needed to ensure cost effectiveness for the trust. In order to run the most efficient service we need a more specific target audience, excluding certain patient groups (variceal surveillance and diabetics) and prioritising others (2 week waits). Variceal surveillance patients had high DNA rates and would be more appropriate on a daytime list where a DNA can be replaced by an inpatient. Diabetics would benefit from morning lists, both for easier glycaemic control and to reduce food bolus (with a longer overnight fast). Improved patient fasting information is essential with specific guidance for pre-fasting meals, with focus on reducing ‘heavy’ foods, particularly rice based meals. Further work is needed to identify other areas for improvement and refine the service, and ultimately produce a protocol for evening endoscopy that is generalisable to UK endoscopy departments. <h3>Reference</h3> NHS Improvement. Rapid Review of Endoscopy Services, March 2012; www.improvement.nhs.uk <h3>Disclosure of Interest</h3> None Declared.
Cytomegalovirus Infection and the Postperfusion Syndrome
Authors: David J. Lang, James B. Hanshaw
Journal: New England Journal of Medicine (1969)

Virologic studies initiated retrospectively resulted in recovery of cytomegalovirus (CMV) from four patients with the postperfusion syndrome and from the urine of one of four donors of fresh blood. In all the patients virus was found in association with circulating leukocytes. Cytomegaloviremia persisted in the face of circulating antibody in three patients. Preoperative serums revaled no measurable CMV antibody in these patients. Complement-fixing antibody to CMV was detected after operation in all four cases and was accompanied or preceded by the appearance of specific anti-CMV macroglobulin. The results of the studies in these four patients with the postperfusion syndrome suggest that the CMV infections demonstrated were primary, and support the concept that this virus, associated with some febrile postperfusion illnesses, may be transmitted with fresh blood in the fraction rich in leukocytes.