tbuckley/cabot-search huggingface dataset:
Incidental Finding of Paraesophageal Hernia on Hepatobiliary Imaging
Authors: KIREN S. JAIN, BRUCE A. LUXON, HENRY M. GOODGOLD
Journal: Clinical Nuclear Medicine (1996)

A 78-year-old woman with a 2-year history of early satiety and vague abdominal pain underwent hepatobiliary scanning for evaluation of possible sphincter of Oddi or gallbladder dysfunction. The scan unexpectedly demonstrated activity within the thorax on delayed imaging, which suggested intrathoracic herniation of bowel or stomach. A follow-up upper gastrointestinal series confirmed a paraesophageal hernia. This case report illustrates a most unusual finding on hepatobiliary scanning that helped to diagnose paraesophageal hernia.
865 NOTCH1 FUNCTIONS AS A TUMOR SUPPRESSOR IN LIVER SINUSOIDAL ENDOTHELIAL CELLS AND ITS DISRUPTION LEADS TO HEPATIC ANGIOSARCOMA IN A DIETHYLNITROSAMINE-INDUCED CANCER MODEL
Authors: M.T. Dill, L. Tornillo, S. Rothweiler, L. Terracciano, M.H. Heim, D. Semela
Journal: Journal of Hepatology (2010)
Successful treatment of life-threatening cytomegalovirus infections with ganciclovir in cardiac transplant recipients
Authors: G.Martin Mullen, Paul J. O'Keefe, Alain Heroux, Maryl R. Johnson, Jeanne O'Sullivan, Roque Pifarre, John A. Robinson, Patrick J. Scanlon, Maria Rosa Costanzo-Nordin
Journal: Journal of the American College of Cardiology (1990)
Linkage of autosomal dominant familial dilated cardiomyopathy to chromosome 9
Authors: Maja Krajinovic, Bruno Pinamonti, Gianfranco Sinagra, Matteo Vatta, Giovanni Maria Severini, Jelena Milasin, Arturo Falaschi, Fulvio Camerini, Mauro Giacca, Luisa Mestroni
Journal: Journal of the American College of Cardiology (1996)
Dissection of the multifunctional “receptor-recycling” endocytic compartment of hepatocytes
Authors: Carlos Enrich, Albert Pol, Maria Calvo, Mònica Pons, Stefan Jäckle
Journal: Hepatology (1999)

The endocytic compartment is a complex intracellular heterogeneous organelle, which consists of an extensive network of tubulo-vesicular membranes extending from the cell surface to the perinuclear area.It is involved in the uptake, sorting, and processing of nutrients, metabolites, hormones, and growth factors; the maintenance of the characteristic distribution of the plasma membrane functional domains in polarized epithelial cells; and the recycling of receptors and ligands.Although the boundaries of the endocytic compartment are not completely defined, several probes, marker proteins, subcellular fractionation, and accurate morphological information have topologically delimited and characterized the ''early/sorting'' as well as the multivesicular ''late'' endosomes.However, the ''recycling endosomes,'' characterized by the enrichment in recycling receptors and depletion of ligands that are routed to lysosomes for degradation, lack a clear-cut definition and intracellular location.Recently, using isolated endosomes, progress has been made towards the biochemical and functional dissection of the endocytic compartment of the rat liver.The compartment of recycling emerges as a very complex fraction containing structures involved in recycling, transcytosis, and the caveolin cycle.The aim of this review is to emphasize the complexity of the ''receptor-recycling'' endocytic compartment in the hepatic trafficking pathways and put together the latest molecular data, which suggest that structures contained in this compartment might be also committed to shuttling the signal transduction machinery from the cell surface to the sorting endosomes.The hepatic cell is a useful experimental epithelial-tissue model for studying the endocytic pathways for 2 reasons: first, hepatocytes are highly active metabolically and contain
Galactorrhoea as side effect of domperidone.
Authors: P A Cann, N W Read, C D Holdsworth
Journal: BMJ (1983)

1395patient and several weeks later from the mother.Genital swabs from the mother were negative for Neisseria gonorrhoeae, Trichomonas vaginalis, and Candida.The baby was initially thought to have severe bronchopneumonia and was treated with parenteral flucloxacillin and amoxycillin, oxygen, and nasogastric feeding.His condition improved slowly.When the results of chlamydia culture became available treatment was changed to oral erythromycin.He recovered and was well at follow up.
Diseases of the Heart
Authors: Arthur J. Moss
Journal: JAMA (1966)

Dr. Friedberg has produced a monumental book. As sole author of this third, and extensively revised edition, Dr. Friedberg brings together by means of an extensive bibliography the latest clinical and research developments in the repidly expanding field of cardiology.  Among the many admirable features of this book is its completeness. This up-to-date volume is heavily referenced, and as a major improvement over the previous edition, all references since 1956 include the full title of the article. About one fifth of the book deals with various aspects of circulatory failure, and the author should be highly commended for unifying recent complex developments in this area into a lucid, clear, and all-encompassing presentation. Cardiac therapy, from open-heart surgery to pharmacotherapy with the newer diuretics such as ethycrinic acid, is well presented.  Only a few typographical errors were evident to this reviewer, but one serious one was noted in the doses of
Recognizing the Depressed Patient, with Essentials of Management and Treatment
Authors: John H. Raach
Journal: JAMA (1961)

This small volume is written primarily for the general practitioner or family physician, since these are the physicians who usually see a depressed patient first. To aid in recognizing these patients, the author has drawn on his vast experience as a psychiatrist. He gives a thorough discussion of the various types of depressive states with their manifold manifestations which mask and confuse the underlying condition. The discussion is illustrated with a few case histories, but, by and large, his thesis is developed by a very pleasant, readable style.  The work can be of considerable assistance in dusting off the cobwebs in the memory of the busy practitioner. Its message is full of hope for depressed patients when recognition is. made early and proper therapy commenced. There is a very helpful chapter discussing the various medications for treatment. These are the type of patients who can, in the vast majority of
Letter: What do community physicians do?
Authors: P Carson
Journal: BMJ (1976)

brain damage and continued excessive drink- ing represents a particularly serious threat to the lives of other road users, and if we are to take this threat seriously the assessment of convicted drunken drivers with the Hal- stead-Reitan test battery and the EMI-Scanner deserves our careful consideration not only as a possible index of current disability but also as a possible prognostic guide.I hope shortly to produce a six-year followup of our series of 33 alcoholics which may tell us whether the likelihood of relapse is related to objective indices of the extent of brain damage.
Mechanism of changes in left ventricular function after acute experimental coronary occlusion
Authors: G. SEDEK, B. LEWARTOWSKI
Journal: Cardiovascular Research (1973)

Ballooning of the ischaemic area, shortening of the circular segment length before ejection (SPE), dP/dt max, left ventricular systolic pressure (LVSP), and circular wall stress were recorded in the left ventricle of the dog heart during coronary occlusion. Occlusion of the artery was followed by quick development of ballooning paralleled by an increase in SPE and in the stress/LVSP ratio, and decrease in dP/dt max. It is concluded that deterioration of ventricular function was due to additional series elasticity provided by ischaemic muscle. This conclusion is mainly based on the increase in SPE parallel with the development of ballooning and decrease in dP/dt max. Stroke volume is additionally compromised by increase in afterload.
Mindfulness based therapy is as effective as antidepressants in preventing depression relapse, study shows
Authors: S. Mayor
Journal: BMJ (2015)

Mindfulness based cognitive therapy, which uses structured training to help people change how they think and feel about experiences, is as effective as long term antidepressant therapy at preventing relapse in depression, a large study comparing the two approaches has found.1

The UK study, reported in the Lancet , randomised 212 adults with recurrent depression to mindfulness based cognitive therapy or to maintenance antidepressants. They had all experienced three or more previous major depressive episodes and …
Primary care must have greater role in China's health system, says OECD
Authors: J. Zarocostas
Journal: BMJ (2010)

China’s spectacular economic growth in recent years has helped improve some health outcomes, such as deaths from infectious diseases, but has been accompanied by an increase in chronic diseases, an analysis by the Organisation for Economic Cooperation and Development says.

Despite the country’s increased wealth, serious problems remain in access to treatment, quality of care, and costs to people in poorer areas, the OECD’s report says.

“Improving health outcomes will require addressing a number of imbalances and incentive problems plaguing the healthcare system, in a context of rapidly rising demand for care,” it says.

At present the Chinese health system is not oriented to preventing chronic diseases, the report says, even though the trend worldwide has been to increase care at the primary level. In China patients prefer to go to hospitals, it says, as doctors in primary care are less qualified …
Orlistat Augments Postprandial Increases In Glucagon-Like Peptide-1 in Obese Type 2 Diabetic Patients
Authors: Taner Damci, Serap Yalin, Huriye Balci, Zeynep Osar, Ustun Korugan, Mucahit Ozyazar, Hasan Ilkova
Journal: Diabetes Care (2004)

We thank Horowitz et al. (1) for their comments on our article (2) on the effect of orlistat on postprandial glucose, insulin, and incretin levels. They raise criticisms regarding the increase in postprandial GLP-1 levels, asserting that it is …
Disseminated histoplasmosis in an English patient with diabetes mellitus.
Authors: A Jariwalla, B R Tulloch, H Fox, J Kelly, R Davies
Journal: BMJ (1977)

Histoplasma capsulatum is not endemic in Britain. We report a case of disseminated histoplasmosis in an English man who had not ventured out of northern Europe for 30 years. The disease presented as painful mouth ulcers and hepatosplenomegaly six months after he had developed maturity-onset diabetes. The origin of the infecting fungus may have been from within the United Kingdom or alternatively it may have existed as an intraoral saprophyte for over 30 years.
Anaphylactic Reaction to Dextrans
Authors: Elliott Michelson
Journal: New England Journal of Medicine (1968)

DEXTRANS have been used extensively as plasma expanders1 and for the treatment of venous thrombosis and emboli,2 traumatic occlusion of vessels,3 peripheral ischemia4 and arterial emboli.5 Despite a large clinical experience with this material in Europe and America, no serious reactions have been reported. The following three cases of severe and anaphylactic reactions followed the use of dextrans during a 12-month period in one community hospital.A 52-year-old woman was admitted to Sinai Hospital of Baltimore for chemotherapy after excision of a malignant melanoma of the left leg 3 weeks before. She had no known allergies. Two weeks after regional . . .
Clinical Experience of the Insulin Zinc Suspensions
Authors: J. M. Stowers, J. D. N. Nabarro
Journal: BMJ (1955)

One observer appeared to be biased against and/or the other towards finding abnormalities in the cotton- workers.The same observer bias occurred in taking histories of symptoms.The importance of observer error in epidemiological studies and possible methods of reducing it are briefly discussed.We are grateful to the Medical Research Council for a grant to study byssinosis.We have had much helpful advice and criticism from our colleagues inside the Department and others, particularly from Dr. J. C. Gilson and his colleagues in the Pneumoconiosis Research Unit, and from Dr. C. M.
Patient‐controlled analgesia versus continuous infusion of morphine during vaso‐occlusive crisis in sickle cell disease, a randomized controlled trial
Authors: Eduard J. van Beers, Charlotte F.J. van Tuijn, Pythia T. Nieuwkerk, Philip W. Friederich, Jan H. Vranken, Bart J. Biemond
Journal: American Journal of Hematology (2007)

Abstract Intravenous morphine is the treatment of choice for severe pain during vaso‐ occlusive crisis in sickle cell disease (SCD). However, side effects of morphine may hamper effective treatment, and high plasma levels of morphine are associated with severe complications such as acute chest syndrome. Furthermore, adequate dosing remains a problem since no objective measurement of pain severity exists and analgesia should be titrated upon the patient's reported pain. Patient‐controlled analgesia (PCA) may therefore be an interesting alternative since patients can titrate the level of analgesia themselves. In this randomized controlled study, the efficacy of intravenous morphine administration with PCA was compared with continuous infusion (CI) of morphine in patients with SCD during vaso‐occlusive crisis. Twenty five consecutive episodes of vaso‐occlusive crisis in 19 patients with SCD were included in the study. Patients in the PCA‐group had a markedly and significant lower mean and cumulative morphine consumption when compared with the patients in the CI‐group (0.5 mg/hr versus 2.4 mg/hr ( P &lt; 0.001) and 33 mg versus 260 mg ( P = 0.018, respectively). The mean daily pain scores were comparable (4.9 versus 5.3). The lower mean and cumulative morphine consumption in the PCA‐group led to significant less nausea and constipation during treatment when compared with the CI‐group (area under the curve, respectively, 11 versus 18 ( P = 0.045) and 30 versus 45 ( P = 0.021). Furthermore, a nonsignificant reduction in the duration of hospital admission of 3 days was observed in the PCA‐group. PCA results in adequate pain relief at a much lower morphine consumption and should considered to be the first choice in morphine administration to sickle cell patients admitted with vaso‐occlusive crisis. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
Phosphorylation of CREB Ser142 Regulates Light-Induced Phase Shifts of the Circadian Clock
Authors: Daniel Gau, Thomas Lemberger, Charlotte von Gall, Oliver Kretz, Nguyet Le Minh, Peter Gass, Wolfgang Schmid, Ueli Schibler, Horst W. Korf, Günther Schütz
Journal: Neuron (2002)
Noninvasive Diagnostic Techniques in Vascular Disease
Authors: Christopher K. Zarins
Journal: JAMA (1986)

Noninvasive Diagnostic Techniques in Vascular Disease is the third edition of a book that has surveyed and kept pace with the rapidly growing field of noninvasive vascular diagnosis. The first edition of the book appeared in 1978 at the time of the initial widespread clinical application of ultrasound and plethysmography to noninvasive vascular diagnosis. Since that time, there has been an explosive growth and expansion of the field, with the development of new techniques, the establishment of noninvasive diagnosis laboratories in most hospitals, and the acceptance of noninvasive vascular diagnosis in standard clinical practice. The second edition appeared in 1982, and now, only three years later, the third edition has arrived.  This third edition contains 87 chapters contributed by 75 authors and has 50 new chapters not present in the second edition. It is broad in scope and covers the fundamentals of measurement and instrumentation, the clinical application of established
Physical Disorder in 164 Admissions to a Mental Hospital
Authors: R. J. Phillips
Journal: BMJ (1937)

DHCELBJOURNAL 363 results may be obtained in the majority of cases, even in medial fractures and in very old patients.It is possible to obtain the fixation necessary for good union by means of the method of extra-articular osteo- synthesis just described.This method is capable of wide application, because it is not necessary to put the patient in plaster-of-Paris afterwards-a fact which reduces the risk of mortality.The after-treatment is thus very much simplified.The conservative treatment, as well as operative treatment with exposure of the fracture, should therefore be replaced by extra-articular osteosynthesis as the standard method.
Patent Foramen Ovale Is Not Associated with Hypoxemia in Severe Chronic Obstructive Pulmonary Disease and Does Not Impair Exercise Performance
Authors: Zarrin F. Shaikh, Julia L. Kelly, Dinesh Shrikrishna, Manuel de Villa, Michael J. Mullen, Nicholas S. Hopkinson, Mary J. Morrell, Michael I. Polkey
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

Rationale: Patent foramen ovale (PFO) may be disadvantageous in chronic obstructive pulmonary disease (COPD). It is unknown whether right-to-left shunting through PFO increases during exercise impairing exercise performance.Objectives: To determine whether (1) PFO prevalence is greater in hypoxemic versus less hypoxemic patients with COPD, (2) PFO is associated with clinically relevant impairment, and (3) right-to-left shunting increases during exercise and impairs exercise performance.Methods: Patients with COPD and age-matched control subjects underwent contrast transthoracic echocardiography and transcranial Doppler to identify PFO. Patients with COPD with no shunt and patients with large PFO underwent cardiopulmonary exercise tests with contrast transcranial Doppler, esophageal, and gastric balloon catheters.Measurements and Main Results: PFO prevalence was similar in 50 patients with COPD and 50 healthy control subjects (46% vs. 30%; P = 0.15). Large shunts were more common in patients with COPD (26% vs. 6%; P = 0.01). In an expanded COPD cohort, PFO prevalence was similar in 31 hypoxemic (Pao2 ≤ 7.3 kPa) and 63 less hypoxemic (Pao2 > 8.0 kPa) patients with COPD (39% vs. 52%; P = 0.27). Patients with intrapulmonary shunting had lower Pao2 than both patients with PFO and those with no right-to-left shunt (7.7 vs. 8.6 vs. 9.3 kPa, respectively; P = 0.002). Shunting significantly increased during exercise in patients with COPD with PFO. Endurance time at 60% Vo2max was 574 (178) seconds for patients with PFO and 534 (279) seconds for those without (P = ns).Conclusions: Hypoxemic patients with COPD do not have a higher prevalence of PFO. Patients with COPD with PFO do not perform less well either on a 6-minute walk or submaximal exercise testing despite increased right-to-left shunting during exercise.
Spacer inhalation technique and deposition of extrafine aerosol in asthmatic children
Authors: C. M. Roller, G. Zhang, R. G. Troedson, C. L. Leach, P. N. Le Souëf, S. G. Devadason
Journal: European Respiratory Journal (2006)

The aim of the present study was to measure airway, oropharyngeal and gastrointestinal deposition of 99m Tc-labelled hydrofluoroalkane-beclomethasone dipropionate after inhalation via a pressurised metered-dose inhaler and spacer (Aerochamber Plus TM ) in asthmatic children. A group of 24 children (aged 5–17 yrs) with mild asthma inhaled the labelled drug. A total of 12 children took five tidal breaths after each actuation (tidal group). The other 12 children used a slow maximal inhalation followed by a 5–10-s breath-hold (breath-hold group). Simultaneous anterior and posterior planar γ-scintigraphic scans (120-s acquisition) were recorded. For the tidal group, mean± sd lung deposition (% ex-actuator, attenuation corrected) was 35.4±18.3, 47.5±13.0 and 54.9±11.2 in patients aged 5–7 (n = 4), 8–10 (n = 4) and 11–17 yrs (n = 4), respectively. Oropharyngeal and gastrointestinal deposition was 24.0±10.5, 10.3±4.4 and 10.1±6.2. With the breath-hold technique, lung deposition was 58.1±6.7, 56.6±5.2 and 58.4±9.2. Oropharyngeal and gastrointestinal deposition was 12.9±3.2, 20.1±9.5 and 20.8±8.8. Inhalation of the extrafine formulation with the breath-hold technique showed significantly improved lung deposition compared with tidal breathing across all ages. Oropharyngeal and gastrointestinal deposition was markedly decreased, regardless of which inhalation technique was applied, compared with a previous paediatric study using the same formulation delivered via a breath-actuated metered-dose inhaler.
A Reusable Sensor for the Label‐Free Detection of Specific Oligonucleotides by Surface Plasmon Fluorescence Spectroscopy
Authors: Gilbert Nöll, Qiang Su, Björn Heidel, Yaming Yu
Journal: Advanced Healthcare Materials (2013)

The development of a reusable molecular beacon (MB)-based sensor for the label-free detection of specific oligonucleotides using surface plasmon fluorescence spectroscopy (SPFS) as the readout method is described. The MBs are chemisorbed at planar gold surfaces serving as fluorescence quenching units. Target oligonucleotides of 24 bases can be detected within a few minutes at high single-mismatch discrimination rates. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Randomized Comparison of Angioplasty of Complex Coronary Lesions at a Single Center
Authors: Nicolaus Reifart, Michel Vandormael, Mladen Krajcar, Stefan Göhring, Wolfgang Preusler, Franz Schwarz, Hans Störger, Manfred Hofmann, Johann Klöpper, Stefan Müller, Jürgen Haase
Journal: Circulation (1997)

Background The purpose of this study was to test whether coronary revascularization with ablation of either excimer laser or rotational atherectomy can improve the initial angiographic and clinical outcomes compared with dilatation (balloon angioplasty) alone. Methods and Results At a single center, a total of 685 patients with symptomatic coronary disease warranting elective percutaneous revascularization for a complex lesion were randomly assigned to balloon angioplasty (n=222), excimer laser angioplasty (n=232), or rotational atherectomy (n=231). The primary end point was procedural success (diameter stenosis &lt;50%, absence of death, Q-wave myocardial infarction, or coronary artery bypass surgery). The patients who underwent rotational atherectomy had a higher rate of procedural success than those who underwent excimer laser angioplasty or conventional balloon angioplasty (89% versus 77% and 80%, P= .0019), but no difference was observed in major in-hospital complications (3.2% versus 4.3% versus 3.1%, P= .71). At the 6-month follow-up, revascularization of the original target lesion was performed more frequently in the rotational atherectomy group (42.4%) and the excimer laser group (46.0%) than in the angioplasty group (31.9%, P= .013). Conclusions Procedural success of rotational atherectomy is superior to laser angioplasty and balloon angioplasty; however, it does not result in better late outcomes. The role of plaque debulking before balloon dilatation in percutaneous coronary revascularization remains to be fully defined.
A randomized controlled trial of α-interferon in acute postransfusion C hepatitis
Authors: L Viladomiu, A González, JC López-Talavera, J Genescá, H Allende, C Sánchez, JM Hernández, I Caragol, M Butt, JI Esteban, R Esteban, J Guardia
Journal: Journal of Hepatology (1990)