Cephaloridine and Penicillin G in the Treatment of Pneumococcal Pneumonia
Authors: BRUCE TEMPEST
Journal: Annals of Internal Medicine (1967)

Article1 June 1967Cephaloridine and Penicillin G in the Treatment of Pneumococcal PneumoniaA Comparative StudyBRUCE TEMPEST, M.D., ROBERT AUSTRIAN, M.D., F.A.C.P.BRUCE TEMPEST, M.D.Search for more papers by this author, ROBERT AUSTRIAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-6-1109 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough penicillin G remains the drug of choice for the treatment of pneumococcal infections in individuals not hypersensitive to it, the potential role of other antimicrobial agents in the management of such infections is of interest for two reasons. First, these agents may be useful as alternatives in the treatment of patients sensitive to penicillin G. Second, it is important to know whether they are comparably effective in eradicating pneumococcal infection unrecognized because of lack of facilities for bacteriologic study.Cephaloridine*is a semisynthetic derivative of cephalosporin C related chemically to cephalothin (1). Like cephalothin, it has a broad antimicrobial...References1. MUGGLETONO'CALLAGHANSTEVENS PWCHWK: Laboratory evaluation of a new antibiotic—cephaloridine (Ceporin). Brit. Med. J. 2: 1234, 1964. CrossrefMedlineGoogle Scholar2. BARBERWATERWORTH MPM Penicillinase-resistant penicillins and cephalosporins. Ibid., p. 344. Google Scholar3. KISLAKSTEINHAUERFINLAND JWBWM: Cephaloridine activity in vitro and absorption and urinary excretion in normal young men. Amer. J. Med. Sci. 251: 433, 1966. CrossrefMedlineGoogle Scholar4. APICELLAPERKINSSASLAW MARLS: Cephaloridine treatment of bacterial infections. Ibid., p. 266. Google Scholar5. COHENROMANSKYJOHNSON PGMJAC: Laboratory and clinical evaluation of cephaloridine in 78 patients, in Antimicrobial Agents and Chemotherapy, edited by HOBBY, G. L. American Society of Microbiology, Ann Arbor, 1965, p. 894. Google Scholar6. GONELLAOLEXYJACKSON JSVMGG: Cephaloridine treatment of bacterial infections. Ibid., p. 901. Google Scholar7. MURDOCHSPEIRSGEDDESWALLACE JMCFAMET: Clinical trial of cephaloridine (Ceporin), a new broad-spectrum antibiotic derived from cephalosporin C. Brit. Med. J. 2: 1238, 1964. CrossrefMedlineGoogle Scholar8. : II. Report of a drug reaction. Allergic reaction to cephalothin in patient with hypersensitivity. Bull. Hopkins Hosp. 118: 352, 1966. Google Scholar9. KABINSEISENSTEINCOHEN SABS: Anaphylactoid reaction to an initial dose of sodium cephalothin. JAMA 193: 165, 1965. CrossrefMedlineGoogle Scholar10. KABINSCOHEN SAS: Cephaloridine therapy as related to renal function, in Antimicrobial Agents and Chemotherapy, edited by HOBBY, G. L. American Society of Microbiology, Ann Arbor, 1965, p. 922. Google Scholar11. STEWARTHOLT GTRJ: Laboratory and clinical results with cephaloridine. Lancet 2: 1305, 1964. CrossrefMedlineGoogle Scholar12. KIRBY WM: Clinical status of cephalothin, in Antimicrobial Agents and Chemotherapy, edited by SYLVESTER, J. C. American Society of Microbiology, Ann Arbor, 1964, p. 274. Google Scholar13. BENNERBENNETTBRODIEKIRBY EJJVJLWM: Inactivation of cephalothin and cephaloridine by Staphylococcus aureus. J. Bact. 90: 1599, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BRUCE TEMPEST, M.D.; ROBERT AUSTRIAN, M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaFrom the Department of Research Medicine, University of Pennsylvania School of Medicine, and the Medical Service, Philadelphia General Hospital, Philadelphia, Pa.This work was supported by grant AI-05100-03, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Robert Austrian, M.D., Department of Research Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pa. 19104.*Provided through the courtesy of Dr. R. S. Griffith, Eli Lilly & Co., Indianapolis, Ind. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOptimal antibiotic therapy in bronchopulmonary infectionsDouble-Blind Comparison of Cefamandole and Penicillin in Pneumococcal PneumoniaThe Cephalosporin Group of AntibioticsA Review of the Clinical Use of Antimicrobial Agents in Patients with Renal and/or Hepatic Insufficiency II. the CephalosporinsA comparative trial of ampicillin and cephaloridine in acute chest infectionsCephalosporinsInfectious diseases. Annual review of significant publications. 1 June 1967Volume 66, Issue 6Page: 1109-1115KeywordsAllergy and immunologyAntimicrobialsDrugsHospital medicineInfectious diseasesMedical servicesPatientsPenicillinPneumonia ePublished: 1 December 2008 Issue Published: 1 June 1967 PDF downloadLoading ...