tbuckley/cabot-search huggingface dataset:
Book: Hitler's Gift: Scientists Who Fled Nazi Germany
Authors: A. Paton
Journal: BMJ (2001)

Jean Medawar, David Pyke Richard Cohen, £20, pp 268 ISBN 1 86066 172 6 Rating: ![Graphic][1]</img>![Graphic][2]</img> Within three months of Hitler coming to power in January 1933, virtually all Jews in state institutions, which included most universities, had been sacked. Anti-Semitism had been rife in Europe for years, but the scale of the purge was unprecedented; some of the best departments were decimated. William Beveridge, director of the London School of Economics and “father” of the NHS, and Lionel Robbins … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
A Convenient Ophthalmoscope for Students and Practitioners
Authors: A. H. Benson
Journal: BMJ (1885)

zoptr being bilateral, instead of on one side only, is not evep mentioned."IJnilateral herpes"' is the name by which it is sometimes known;and the recognition of the almost invaTiable rule of its attacking but one side of the trunk, extremTlities, or face, is of great diagnostic value in contrasting it with catarrhal or simple herpes, which attacks one or both sides indifferently.In the comparatively few instances on record of bilateral herpes zoster, the eruption, as in the above case, is not on exactly the same level; but the cutaneous nerves attacked on one side are on a higher or lower level than those on the other side.
1087. Adeno-Associated Virus-Mediated Transduction of VEGF165 Markedly Improves Functional Recovery of Infarcted Myocardium in Chronically Instrumented Dogs
Authors: Matteo Ferrarini, Nikola Arsic, Serena Zacchigna, Fabio Recchia, Lorena Zentilin, Mauro Giacca, Thomas Hintze
Journal: Molecular Therapy (2005)

Top of pageAbstract
We have previously found that the delivery of the VEGF165 cDNA into skeletal muscle using AAV vectors, not only stimulates angiogenesis and arteriogenesis, but also exerts a remarkable anti-apoptotic and pro-regenerative activity during severe ischemic injury. Based on these observations, the aim of the present study was to test whether rAAV-VEGF165 delivery into cardiac tissue, during the acute phase of myocardial infarction, exerts a protective effect on the injured myocardium and promotes long-term functional recovery. Acute infarction of the anterior LV wall was induced in twelve chronically instrumented dogs by permanent occlusion of the LAD coronary artery. Four hours after occlusion, using an echo-guided needle, we injected rAAV-VEGF (n= 6; 4x1012 viral particles per animal) or rAAV-LacZ (n=6) directly into the paradoxical segment. Hemodynamics, echocardiographic data and segmental shortening of the infarcted region were measured at baseline (pre-occlusion) and monitored repeatedly during the subsequent four weeks. Histological analysis was performed at the end of the study. LV and arterial systolic and mean pressure, LV dP/dtmax and ejection fraction were not significantly different between the two groups over time. In contrast, the indexes of contraction of the infarcted area displayed marked differences after the second week post-infarction: at four weeks, the fractional shortening was 75 |[plusmn]|18% and |[minus]|3 |[plusmn]|15% of baseline and regional shortening work was 54 |[plusmn]|15% and 0.8 |[plusmn]|15% of baseline in rAAV-VEGF165 vs. LacZ group, respectively (P<0.05). Histological analysis of the border regions between the infarcted and viable cardiac tissue showed a marked increase in the number of |[alpha]|-SMA-positive arterioles (50|[ndash]|120 |[mu]|m diameter; 68|[plusmn]|2.8 vs. 100|[plusmn]|3.8 vessels per 100x microscopic field in the LacZ and VEGF-treated animals respectively; p<0.05). In the same areas, few c-kit-positive cells (1|[ndash]|3 per field) were observed and these only in the VEGF-treated group. The histological analysis of transmural sections showed a significant improvement in myocardial viability in the VEGF group; in accordance, several troponin T-expressing cardiomyocytes displayed a clear nuclear positivity for the proliferation marker PCNA suggesting an ongoing process of active myocardial regeneration. Interestingly, in both groups of animals, the expression of the three main VEGF receptors (VEGFR-1, VEGFR-2 and NP-1) was clearly up-regulated in the border of the infarct. In particular, VEGFR-2 was found to be expressed diffusely on the surviving cardiomyocytes, reinforcing the notion of a possible direct role of VEGF in myocardial protection and/or regeneration.
The Ohio Cases not Leprosy.
Authors: Albert S. Ashmead
Journal: JAMA (1895)

New York, Nov. 7,1895. <h3>To the Editor:</h3> —You published in theJournal, November 2, an article in which Dr. McDougal asks, after describing two cases, "is this leprosy?" In my opinion they are not lepers. I inclose you a letter I wrote to Dr. McDougal. <h3>Dear Dr. McDougal:</h3> —Thanks for your information about the supposed leper cases, and for your article which you were kind enough to send me. I have written my opinion to Dr. Morrow, who had sent me the photograph of the cases. I do not consider them lepers. Colles law, I think, proves them to be syphilitic. Certainly if they were lepers, the mother would have been infected too. Yours truly,
Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case report
Authors: Martin Markowitz, Hiroshi Mohri, Saurabh Mehandru, Anita Shet, Leslie Berry, Roopa Kalyanaraman, Alexandria Kim, Chris Chung, Patrick Jean-Pierre, Amir Horowitz, Melissa La Mar, Terri Wrin, Neil Parkin, Michael Poles, Christos Petropoulos, Michael Mullen, Daniel Boden, David D Ho
Journal: The Lancet (2005)
Acute Brain Syndrome Associated with Lithium Therapy
Authors: PETER L. AGULNIK, ALBERTO DIMASCIO, PATRICIA MOORE
Journal: American Journal of Psychiatry (1972)

Three patients who were treated with lithium displayed symptoms resembling those of organic brain syndrome when their blood lithium levels were low. All patients' lithium levels were slow to rise. When lithium was stopped, the patients' blood levels began to rise and then fell, at which time their symptoms remitted. The authors postulate that this lithium toxicity may possibly be due to tissue lithium levels.
An Unusual First Impression of Skull Base Metastasis"The Sunglasses Illusion"
Authors: CHARLES W. SUTTER, BENEDICTO G. MASILUNGAN, DAVID K. SHELTON
Journal: Clinical Nuclear Medicine (1996)

A 64-year-old woman with breast carcinoma underwent a modified right mastectomy and axillary node dissection in 1991. The tumor was estrogen receptor positive and she was started on tamoxifen. The patient did well until 1994, when a painful left clavicular lump developed. A bone scan was performed, which revealed an unusual illusion—that of the appearance of "sunglasses." Lateral images confirm skull base metastasis as the etiology for the illusion.
First Americans Face Their Latest Challenge: Indian Health Care Meets State Medicaid Reform
Authors: Marsha F. Goldsmith
Journal: JAMA (1996)

AMERICAN INDIANS know a lot about "reform." If some people had had their way, Native American tribes would have been reformed out of existence a century ago. So it's not surprising that members of some 500 federally recognized tribes that remain are wary when talk in their locality turns to "health care reform." Gerald Hill, MD, a past president of the Association of American Indian Physicians, spoke about "The Indian Health Care System and State Health Care Reform" at the annual meeting of the National Rural Health Association last month in Minneapolis, Minn. He contrasted the Indians' aims—respect for and preservation of tribal sovereignty, continued delivery of culturally appropriate health care services, and maintenance and improvement of the Indian health care system funding base—with the states' desire to reduce Medicaid spending and improve the access of tribal members to other types of health insurance as well as to health services.
Staphylococcal Endocarditis in Parenteral Drug Abusers: Source of the Organism
Authors: CARMELITA U. TUAZON
Journal: Annals of Internal Medicine (1975)

Because approximately one third of persons injecting illicit drugs carry Staphylococcus aureus in their nose and throat or on the skin, we wondered if the carrier was the person in the drug-injecting population at risk of developing endocarditis. If so, patients with drug-related, staphylococcal endocarditis should have a very high carriage rate of the organism when first admitted to the hospital. Ten such patients were studied within 3 days of admission, and all were carriers of S. aureus. In each case, the phage type of the carried organism matched that of the organism recovered from the blood.
Erythrocyte Sodium-Hydrogen Exchange and Microalbuminuria in Type I Diabetes
Authors: Ottavio Giampietro, Elena Matteucci, Roberto Pedrinelli
Journal: Diabetes Care (1996)

OBJECTIVE To evaluate the relationship between sodium-hydrogen (Na+/H+) exchange and microalbuminuria (an abnormal urinary albumin/creatinine ratio in morning collections) in IDDM patients. RESEARCH DESIGN AND METHODS Amiloride-sensitive H+ efflux from cells acid loaded at pH 6.5 (defined as erythrocyte Na+/H+ exchange) was measured in normotensive IDDM patients with microalbuminuria and normal renal function (n = 16, serum creatinine &amp;lt; 106.1 μmol/l) and compared with both matched uncomplicated normoalbuminuric diabetic subjects and normal subjects (n = 16 each). RESULTS Erythrocyte Na+/H+ exchange was elevated to a similar extent in diabetic patients with and without microalbuminuria. Blood pressure and lipids were normal in both diabetic groups. Daily insulin requirement, blood glucose, and glycated hemoglobin were higher and retinopathy more frequent in microalbuminuric patients. CONCLUSIONS The abnormal erythrocyte Na+/H+ exchange of type I diabetic patients was unrelated to microalbuminuria and could not be ascribed to hypertension or dyslipidemia. Furthermore, the degree of metabolic control seemed to influence the progression of diabetic nephropathy, but not the abnormal antiport activity. The data imply that Na+/H+ exchange is an unlikely marker of nephropathy in type I diabetic patients.
One year on: hospital leaders say they are acting on Francis report
Authors: J. Wise
Journal: BMJ (2014)

Senior NHS staff have said that the 2013 report by Robert Francis QC added impetus to their efforts to put quality of care as a top priority, but they said that meeting financial goals and ensuring safe staffing levels were very difficult and would only get harder in the future.1

The Francis Report: One Year On explores the response of acute hospital trusts in England to last year’s damning report on the Mid Staffordshire NHS Foundation Trust.2 3 The new research, carried out by the health policy think tank the Nuffield Trust, is based on 48 in-depth interviews with senior staff at five case study hospitals and the responses of 53 hospital trusts …
Indomethacin serum concentrations in man. Effects of dosage, food, and antacid.
Authors: H W Emori, H Paulus, R Bluestone, G D Champion, C Pearson
Journal: Annals of the Rheumatic Diseases (1976)

In the use of anti-inflammatory compounds, sustained serum levels are thought to be related to drug efficacy. This study shows that frequent clinical administration of indomethacin can result in sustained serum levels of the drug and that food and antacid may have important modifying effects on serum indomethacin concentrations. After oral ingestion by fasting subjects, indomethacin rapidly appeared in the serum, usually reaching peak concentrations in 30 to 90 minutes. Food delayed and decreased the mean peak level; antacid delayed the peak and slightly enhanced subsequent concentrations. With multiple dose schedules plateau levels were reached after 24 hours. When a total daily dose of 150 mg was given as 25 mg every 4 hours peak concentrations were the same but fluctuations were smaller and average concentrations were higher than with a dosage of 50 mg every 8 hours.
GW25-e3549 Epidemiological survey of valvular heart disease in five years: Changes in prevalence, etiological spectrum and management in a single cardiovascular center of Southern China
Authors: Liu Fangzhou, Wu Shulin, Xue Yumei, Wei Wei, Zhan Xianzhang, Fang Xianhong, Liao Hongtao, Liu Yang, Lin Weidong, Liang Yan, Li Xin
Journal: Journal of the American College of Cardiology (2014)
Can We Identify Sources of Fine Particles Responsible for Exercise-Induced Ischemia on Days with Elevated Air Pollution? The ULTRA Study
Authors: Timo Lanki, Jeroen J. de Hartog, Joachim Heinrich, Gerard Hoek, Nicole A.H. Janssen, Annette Peters, Matthias Stölzel, Kirsi L. Timonen, Marko Vallius, Esko Vanninen, Juha Pekkanen
Journal: Environmental Health Perspectives (2006)

Epidemiologic studies have shown that ambient particulate matter (PM) has adverse effects on cardiovascular health. Effective mitigation of the health effects requires identification of the most harmful PM sources. The objective of our study was to evaluate relative effects of fine PM [aerodynamic diameter ≤ 2.5 μm (PM2.5)] from different sources on exercise-induced ischemia. We collected daily outdoor PM2.5 samples between autumn 1998 and spring 1999 in Helsinki, Finland. The mass of PM2.5 was apportioned between five sources. Forty-five elderly nonsmoking persons with stable coronary heart disease visited a clinic biweekly for submaximal exercise testing, during which the occurrence of ST segment depressions was recorded. Levels of PM2.5 originating from local traffic and long-range transport were associated with ST segment depressions > 0.1 mV, with odds ratios at 2-day lag of 1.53 [95% confidence interval (CI), 1.19–1.97] and 1.11 (95% CI, 1.02–1.20) per 1 μg/m3, respectively. In multipollutant models, where we used indicator elements for sources instead of source-specific PM2.5, only absorbance (elemental carbon), an indicator of local traffic and other combustion, was associated with ST segment depressions. Our results suggest that the PM fraction originating from combustion processes, notably traffic, exacerbates ischemic heart diseases associated with PM mass.
Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study.
Authors: M R Malinow, F J Nieto, M Szklo, L E Chambless, G Bond
Journal: Circulation (1993)

BACKGROUND Plasma levels of homocyst(e)ine are elevated in certain patients with occlusive arterial diseases. We extended these findings to asymptomatic adults. METHODS AND RESULTS We determined plasma homocyst(e)ine levels in 287 pairs of asymptomatic adults. Cases and controls were defined on the basis of intimal-medial thickness of the carotid wall as measured by B-mode ultrasound. Study subjects had no history of atherosclerotic disease and were selected from a probability sample of 15,800 men and women between 45 and 64 years old. Subjects with thickened intimal-medial carotid walls (cases) had higher plasma homocyst(e)ine levels than controls (p &lt; 0.001). The odds ratio for having a thickened carotid artery wall was 3.15 (p &lt; 0.001) for subjects in the top quintile of plasma homocyst(e)ine levels (&gt; 10.5 mumol/L) compared with those in the bottom quintile (&lt; 5.88 mumol/L). CONCLUSIONS The present study as well as observations on the common occurrence of elevated plasma homocyst(e)ine levels in patients with occlusive arterial diseases suggest that clinical trials should be conducted to determine whether normalization of hyperhomocyst(e)inemia may prevent progression of atherosclerosis.
The Utility of Preimmunization and Postimmunization Titers to 23 Serotypes of Streptococcus Pneumoniae in the Diagnosis of Specific Antibody Deficiency in Children
Authors: Andrew L. Kau, Maleewan Kitcharoensakkul, Avraham Beigelman, Leonard B. Bacharier
Journal: Journal of Allergy and Clinical Immunology (2015)
Treatment of Bechçet's Syndrome With Transfer Factor
Authors: Robert E. Wolf
Journal: JAMA (1977)

Six patients with Behçet's syndrome were treated with transfer factor (TF) from randomly selected donors. Mucocutaneous symptoms and signs were predominant at the time that TF injections were started. Three patients showed great improvement, one moderate improvement, and one was unresponsive to multiple injections of TF from different donors. One case was uninterpretable because of concomitant administration of high doses of prednisone and chlorambucil and brief treatment with TF. These results indicate that TF therapy may be beneficial in some patients with Behçet's syndrome and that a trial of TF is warranted at least in the absence of severe ocular or neurologic manifestations.
Three further cases of Lyme disease.
Authors: D E Bateman, J E White, G Elrington, N F Lawton, M F Muhlemann, R J Greenwood
Journal: BMJ (1987)

3 nouvelles observations de maladie de Lyme avec complications neurologiques en Angleterre. Les vecteurs du spirochete B. burgdorferi sont communs dans la region. Le diagnostic devrait etre envisage plus souvent. Efficacite du traitement par antibiotiques sauf peut etre pour les paralysies faciales
The Medical Profession in Denmark.
Authors: P. C. Clemensen
Journal: JAMA (1907)

Copenhagen, Denmark, Jan. 23, 1907. <h3>To the Editor:</h3> —I have thought it might be of interest to send a word toThe Journalfrom Copenhagen, as most American physicians who go to Europe seek some of the larger European cities for study and clinical observation, and only touch Copenhagen for a few hours to see the Finsen Light Institute. InThe Journal, April 12, 1902, I contributed an article on "Finsen's Phototherapy." I can say now from personal observation, that splendid results are obtained at the Finsen Institute with concentrated, cooled electric light. I have been especially impressed with the frequency of lupus vulgaris of the mucous surfaces of the nose, the hard palate and the pharynx. In treating these cases the same lamps are used as in the treatment of lupus of the skin, except that the light is passed through a reflector to the affected area. To Americans
Abstract 3814: Signet-ring cell gastric carcinoma has different epigenetic signature from poorly differentiated gastric carcinoma
Authors: Hyun Soo Kim, Hong Jun Park, Misuk Yang
Journal: Cancer Research (2011)

Abstract Background/Aim: Gastric cancer is divided into differentiated intestinal type and undifferentiated diffuse type by the most widely used Lauren's classification, which appear clearly as dissimilar clinical and epidemiological entities. Undifferentiated diffuse type gastric cancer is also classified into poorly differentiated carcinoma and signet-ring cell carcinoma (SRCC). However, recent evidences suggest early SRCC is an initial, differentiated form of diffuse gastric cancer that may evolve into poorly differentiated carcinoma (PDC). To test the hypothesis that molecular epigenetic signature of SRCC is different from that of PDC in early gastric carcinogenesis, we compared epigenetic methylation profile between SRCC and PDC and found unique epigenetic signature of SRCC. Methods: Six genes (GDNF, ROR-a, KLF7, MINT25, E-cadherin (CDH1), and LINE-1) were identified as sensitive molecular markers of early gastric cancer at a previous study. We evaluated the DNA methylation patterns of 4 gene promoters (GDNF, ROR-a, KLF7 and LINE-1(long interpersed nuclear element-1)) by bisulfite-PCR and pyrosequencing in primary tissues from 33 PDCs and 20 SRCCs as a test group. Then, the methylation status of the 6 genes including MINT25 and E-cadherin (CDH1) was next evaluated in endoscopically biopsied gastric cancer tissues from prospectively collected 21 PDCs and 22 SRCCs as a validation group. Results: In the test group, quantitative methylation levels of 3 genes (GDNF, ROR-a, and LINE-1) of SRCCs were significantly different from those of PDCs. MINT25, E-cadherin including the above 4 genes were next evaluated in the validation group. We confirmed the significant different levels of methylations of prospectively collected SRCCs from PDCs. Compared to PDCs, SRCCs showed the lower level of methylations for GDNF (17.7% vs. 31.0%, p = 0.001) and ROR-a (14.4% vs. 28.0%, p = 0.001) genes. Interestingly, however, the methylation level of E-cadherin was higher in SRCCs than that of PDCs (26.8% vs. 20.5%, p = 0.009). Methylaion levels of LINE-1 (63.0% vs. 60.5%), MINT25 (31.1% vs. 34.3%) and KLF7 (10.2% vs. 18.1%) in SRCCs were not significantly different from those of PDCs. Conclusion: Our results identified unique methylation patterns of SRCCs distinguished from PDCs, suggesting different molecular epigenetic signature of SRCC in gastric carcinogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3814. doi:10.1158/1538-7445.AM2011-3814
Fusion Imaging Between Myocardial Perfusion Single Photon Emission Computed Tomography and Cardiac Computed Tomography
Authors: Takeshi Nakaura, Daisuke Utsunomiya, Shinya Shiraishi, Seiji Tomiguchi, Koichi Kawanaka, Tsuyoshi Honda, Kazuo Awai, Yasuyuki Yamashita
Journal: Circulation (2005)
Sublingual House Dust Mite (hdm) Immunotherapy, In Children With Extrinsic Allergic Form Of Atopic Dermatitis. A Randomized Controlled Trial On Prevention Of Appearance Of Asthma Or Rhinitis
Authors: G.B. Pajno, L. Caminiti, D. Vita, C. Profazio
Journal: Journal of Allergy and Clinical Immunology (2010)
Intensive Glucose Control in Hyperglycemic Patients With Acute Coronary Syndromes
Authors: Paresh Dandona, William E. Boden
Journal: JAMA Internal Medicine (2013)

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