The Cimetidine-Lidocaine Interaction
Authors: ALBERT B. KNAPP
Journal: Annals of Internal Medicine (1983)

Short Papers1 February 1983The Cimetidine-Lidocaine InteractionALBERT B. KNAPP, M.D., WILLIAM MAGUIRE, M.D., Ph.D., GAD KEREN, M.D., ARTHUR KARMEN, M.D., BARRIE LEVITT, M.D., DENNIS S. MIURA, M.D., Ph.D., JOHN C. SOMBERG, M.D.ALBERT B. KNAPP, M.D.Search for more papers by this author, WILLIAM MAGUIRE, M.D., Ph.D.Search for more papers by this author, GAD KEREN, M.D.Search for more papers by this author, ARTHUR KARMEN, M.D.Search for more papers by this author, BARRIE LEVITT, M.D.Search for more papers by this author, DENNIS S. MIURA, M.D., Ph.D.Search for more papers by this author, JOHN C. SOMBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-2-174 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLidocaine is a widely used antiarrhythmic agent whose plasma clearance varies with changes in hepatic blood flow. Cimetidine, an H2-receptor antagonist, has been shown to decrease hepatic blood flow. To ascertain whether cimetidine affected serum lidocaine concentration, we studied 21 patients receiving lidocaine infusions and divided them into two groups. Fifteen patients received cimetidine, 300 mg every 6 hours, in addition to lidocaine; six patients received only lidocaine. In 14 of the 15 patients receiving both lidocaine and cimetidine, a rise in serum lidocaine levels was seen, whereas no change was noted in the control group. Six of the 15...References1. HOLLUNGER G. On the metabolism of lidocaine: I. The properties of the enzyme system responsible for the oxidative metabolism of lidocaine. Acta Pharmacol Toxicol (Copehn). 1960;17:356-64. CrossrefGoogle Scholar2. SUNGTRUANT CA. The physiologic disposition of lidocaine and its comparison in some respects with procaine. J Pharmacol Exp Ther. 1954;112:432-43. MedlineGoogle Scholar3. GEORGE C. Drug kinetics and hepatic blood flow. 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CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bronx, New York▸From the Division of Cardiology, Department of Medicine, and the Division of Clinical Pharmacology, Department of Molecular Pharmacology, Albert Einstein College of Medicine; Bronx, New York. 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FRANK, M.D., JOHN J. SEAMAN, D.P., KARL E. PEACE, PH.D., RALPH M. MYERSON, M.D., THOMAS J. HUMPHRIES, M.D.Cimetidine and LidocaineJ. ROBERT POWELL, PHARM. D. 1 February 1983Volume 98, Issue 2Page: 174-177KeywordsAttentionBlood flowBlood plasmaClinical pharmacologyHeartHospital medicineIntensive care unitsPharmacology Issue Published: 1 February 1983 Copyright & Permissions© 1983 American College of PhysiciansPDF downloadLoading ...