tbuckley/cabot-search huggingface dataset:
The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study
Authors: VM Whitehead, C Payment, L Cooley, SJ Lauer, DH Mahoney, JJ Shuster, M-J Vuchich, ML Bernstein, AT Look, DJ Pullen, B Camitta
Journal: Leukemia (2001)
Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study
Authors: C Visco, Y Li, Z Y Xu-Monette, R N Miranda, T M Green, Y Li, A Tzankov, W Wen, W-m Liu, B S Kahl, E S G d'Amore, S Montes-Moreno, K Dybkær, A Chiu, W Tam, A Orazi, Y Zu, G Bhagat, J N Winter, H-Y Wang, S O'Neill, C H Dunphy, E D Hsi, X F Zhao, R S Go, W W L Choi, F Zhou, M Czader, J Tong, X Zhao, J H van Krieken, Q Huang, W Ai, J Etzell, M Ponzoni, A J M Ferreri, M A Piris, M B Møller, C E Bueso-Ramos, L J Medeiros, L Wu, K H Young
Journal: Leukemia (2012)
Electrokymographic Studies in Insufficiency of the Aortic and Pulmonic Valves
Authors: HOWARD E. HEYER, ERNEST POULOS, JULIAN H. ACKER
Journal: Circulation (1950)

The following paper describes the results of electrokymographic studies performed on patients with proved aortic insufficiency. Alterations in the shape of the aortic ejection curve were found and were accompanied by a diminution or absence of the incisura in the presence of insufficiency of the aortic valves. Alterations in heart border motion of the ventricles were also found. The possible dynamic factors responsible for these changes are discussed and the clinical application of the electrokymograph to aortic and pulmonic valvular disease is pointed out.
Treatment of advanced mycosis fungoides/Sezary syndrome with fludarabine and potential adjunctive benefit to subsequent extracorporeal photochemotherapy
Authors: P. Quaglino, M.T. Fierro, G.L. Rossotto, P. Savoia, M.G. Bernengo
Journal: British Journal of Dermatology (2004)

Purine analogues [fludarabine monophosphate (FAMP); deoxycoformycin and 2-chlorodeoxyadenosine) and extracorporeal photochemotherapy (ECP) have been suggested to be active agents in advanced cutaneous T-cell lymphoma (CTCL) patients.To explore further the clinical efficacy and safety of FAMP monochemotherapy in advanced CTCL and to evaluate if the sequential association of ECP to FAMP in selected patients may improve the response rate (RR) and/or lengthen the remission duration.Forty-four CTCL patients [17 Sézary syndrome (SS); 26 mycosis fungoides (MF), stage IIB-IV or with peripheral blood involvement; one MF associated with lymphomatoid papulosis (LyP)] were enrolled in this pilot cohort study. All the patients received FAMP 25 mg m(-2) 5 days monthly; 19 patients (43.2%) underwent ECP after FAMP was discontinued. The majority of patients with erythrodermic CTCL or peripheral blood involvement underwent the combined FAMP-ECP schedule.After a median follow-up of 4.2 years, the overall FAMP RR was 29.5% (13/44); a higher RR was obtained in SS (35.3%) than in MF patients (25.9%). According to the treatment group, the RR of the FAMP-ECP group (63.2%) was significantly higher than that of the FAMP monotherapy group (24%; P=0.021). No statistically significant difference was found in time-to-progression (TTP) or survival by therapy group, even if the TTP of the patients treated with the FAMP-ECP combination therapy was higher (median 13 vs. 7 months). A decrease or a normalization in the CD4+CD26- circulating subset was observed in responding patients, paralleling the reduction in the circulating Sézary cells.FAMP confirms its clinical activity as a single agent in SS; conversely, FAMP results do not compare favourably with other therapeutic approaches for advanced stage MF patients. The sequential association of ECP after FAMP seems to increase the RR, even if future randomized studies are needed to confirm these results.
Treatment of Cryptococcal Meningitis in AIDS
Authors: Russell D. Wong
Journal: Annals of Internal Medicine (1990)

Letters15 December 1990Treatment of Cryptococcal Meningitis in AIDSRussell D. Wong, MD, Goetz Matthew B., MDRussell D. Wong, MDSearch for more papers by this author, Goetz Matthew B., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-12-992_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In their recent article, Larsen and colleagues (1) report that patients with AIDS who had acute cryptococcal meningitis responded more frequently to reatment with amphotericin B and flucytosine than to treatment with fluconazole. We believe, however, that further amplification of several points is necessary to determine the feasibility of such combination therapy in these patients and to better show the contribution of flucytosine.First, we are uncertain as to how frequently flucytosine dosing was interrupted because of the development of flucytosine toxicity; although the incidence of hepatitis, diarrhea, anemia, and thrombocytopenia is well described, there is no...References1. LarsenLealChan RML. Fluconazole compared with amphotericin plus flucytosine for cryptococcal meningitis in AIDS. Ann Intern Med. 1990;113:183-7. LinkGoogle Scholar2. ChuckSande SM. Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N Engl J Med. 1989;321:794-9. CrossrefMedlineGoogle Scholar3. ZugerLouieHolzman AER. Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1986;104:234-40. LinkGoogle Scholar4. KovacsKovacsPolis JAM. Cryptococcosis in the acquired immunodeficiency syndrome. Ann Intern Med. 1985;103:533-8. LinkGoogle Scholar1. StammDiasioDismukes ARW. Toxicity of amphotericin B plus flucytosine in 194 patients with cryptococcal meningitis. Am J Med. 1987;83:236-42. CrossrefMedlineGoogle Scholar2. LarsenLealChan RML. Fluconazole compared with amphotericin B plus flucytosine for cryptococcal meningitis in AIDS. Ann Intern Med. 1990;113:183-7. LinkGoogle Scholar3. BennettDismukesDuma JWR. A comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptococcal meningitis. N Engl J Med. 1979;301:126-31. CrossrefMedlineGoogle Scholar4. BozzetteLarsenChiu SRJ. Successful secondary prophylaxis of cryptococcal meningitis with fluconazole: a placebo-controlled trial. Program and Abstracts of the 30th Interscience Conference on Antimicrobial Agents and Chemotherapy, October 20-24, 1990, Atlanta, Georgia. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Sepulveda Veterans Affairs Medical Center Sepulveda, CA 91343 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1990Volume 113, Issue 12Page: 992-992KeywordsAIDSAmphotericinAnemiaCryptococcal meningitisDiarrheaHepatitisToxicity Issue Published: 15 December 1990 PDF DownloadLoading ...
Psoriasis after cord blood stem cell transplantation
Authors: T. Hubiche, C. Leaute-Labreze, S. Lepreux, Y. Perel, A. Taïeb
Journal: British Journal of Dermatology (2006)

Conflicts of interest: none declared. Sir, A 12‐year‐old girl with Kostman syndrome underwent an allogeneic cord blood transplantation (CBT) for an acute lymphoblastic leukaemia. Kostman syndrome (congenital neutropenia) was diagnosed at the age of 3 days following an ecthyma gangrenosum due to Pseudomonas aeruginosa. She had recurrent cutaneous/systemic infections during childhood. The frequency of infections decreased when a treatment with granulocyte–monocyte colony‐stimulating factor was begun. At the age of 12 years, an acute lymphoblastic leukaemia was diagnosed. Chemotherapy, including vincristine, daunorubicine, dexamethasone, aracytine, prednisolone, methotrexate, cyclophosphamide and adriamycine was begun. A CBT was performed 4 months later. The patient was HLA A02,29; B44,40; DRB1*0401,0801; DRB4*0103; DQB1*0301,0402 and the donor was HLA A02,00; B44,40; DRB1*0401,0801; DRB4*0103; DQB1*0301,0402. The conditioning regimen consisted of cyclophosphamide and fractioned total body irradiation. Despite a treatment with ciclosporin (25 mg kg−1 daily) and prednisone (1 mg kg−1 daily dose), an acute graft‐versus‐host disease (GVHD) appeared at day 20 with skin, liver and intestine involvement. A grade 2 GVHD was diagnosed on skin histology. Ciclosporin and prednisone were increased with an improvement of the symptoms. At day 77, the patient outgrew aplasia, the chimerism for blood cells was 100% donor type. Because of hypertension, ciclosporin was stopped on day 137 and replaced with mycophenolate mofetil (75 mg kg−1 daily) and atenolol (25 mg daily) treatment was begun. GVHD totally regressed and the immunosuppressive treatment was decreased and stopped at day 180. Five days later, the patient was examined because of the onset of erythroderma (Fig. 1). There were no histological arguments for an intestinal GVHD relapse and the liver enzymes were normal. The skin biopsy (Fig. 2) showed parakeratosis, epidermal hyperplasia, Munro–Sabouraud abcesses, and an inflammatory infiltrate around the dermal papillary capillaries; all the features were in strong favour of a diagnosis of erythrodermic psoriasis. Neither the patient's HLA antigens nor the donor's HLA antigens were associated with psoriasis and the patient had no history of psoriasis. Topical corticosteroid improved the skin symptoms. The patient died 1 month later of septicaemia.
CD74 interacts with APP and suppresses the production of Aβ
Authors: Shuji Matsuda, Yukiko Matsuda, Luciano D'Adamio
Journal: Molecular Neurodegeneration (2009)

Alzheimer disease (AD) is characterized by senile plaques, which are mainly composed of beta amyloid (Abeta) peptides. Abeta is cleaved off from amyloid precursor protein (APP) with consecutive proteolytic processing by beta-secretase and gamma-secretase.Here, we show that CD74, the invariant chain of class II major histocompatibility complex, interacts with APP and serves as a negative regulator of Abeta. CD74 resembles other APP interacters such as BRI2 and BRI3, since all of them reduce the level of Abeta. However, unlike BRIs, CD74 does not reduce the secretion of sAPPalpha or sAPPbeta. Interestingly, in HeLa cells, over expression of CD74 steers APP, but not Notch, to large vacuoles created by CD74.Taken together, we propose that CD74 inhibits Abeta production by interacting with and derailing normal trafficking of APP.
Hydrogels: Glacier Moraine Formation‐Mimicking Colloidal Particle Assembly in Microchanneled, Bioactive Hydrogel for Guided Vascular Network Construction (Adv. Healthcare Mater. 2/2015)
Authors: Min Kyung Lee, Max H. Rich, Artem Shkumatov, Jae Hyun Jeong, Marni D. Boppart, Rashid Bashir, Martha U. Gillette, Jonghwi Lee, Hyunjoon Kong
Journal: Advanced Healthcare Materials (2015)

On page 195 J. Lee, H. J. Kong, and colleagues demonstrate a new method to align microparticles releasing bioactive molecules in microchannels of a hydrogel, allowing the guiding of growth direction and spacing of vascular networks.
Resection of Non–Small Cell Lung Cancers Reverses Tumor-Induced Gene Expression Changes in the Peripheral Immune System
Authors: Andrew V. Kossenkov, Anil Vachani, Celia Chang, Calen Nichols, Shere Billouin, Wenhwai Horng, William N. Rom, Steven M. Albelda, Michael K. Showe, Louise C. Showe
Journal: Clinical Cancer Research (2011)

To characterize the interactions of non-small cell lung cancer (NSCLC) tumors with the immune system at the level of mRNA and microRNA (miRNA) expression and to define expression signatures that characterize the presence of a malignant tumor versus a nonmalignant nodule.We have examined the changes of both mRNA and miRNA expression levels in peripheral blood mononuclear cells (PBMC) between paired samples collected from NSCLC patients before and after tumor removal using Illumina gene expression arrays.We found that malignant tumor removal significantly changes expression of more than 3,000 protein-coding genes, especially genes in pathways associated with suppression of the innate immune response, including natural killer cell signaling and apoptosis-associated ceramide signaling. Binding sites for the ETS domain transcription factors ELK1, ELK4, and SPI1 were enriched in promoter regions of genes upregulated in the presence of a tumor. Additional important regulators included five miRNAs expressed at significantly higher levels before tumor removal. Repressed protein-coding targets of those miRNAs included many transcription factors, several involved in immunologically important pathways. Although there was a significant overlap in the effects of malignant tumors and benign lung nodules on PBMC gene expression, we identified one gene panel which indicates a tumor or nodule presence and a second panel that can distinguish malignant from nonmalignant nodules.A tumor presence in the lung influences mRNA and miRNA expression in PBMC and this influence is reversed by tumor removal. These results suggest that PBMC gene expression signatures could be used for lung cancer diagnosis.
The Teaching and Practice of Cardiac Auscultation during Internal Medicine and Cardiology Training: A Nationwide Survey
Authors: Salvatore Mangione
Journal: Annals of Internal Medicine (1993)

Objectives: To assess the time and importance given to cardiac auscultation during internal medicine and cardiology training and to evaluate the auscultatory proficiency of medical students and physicians-in-training. Study Design: A nationwide survey of internal medicine and cardiology program directors and a multicenter cross-sectional assessment of students' and housestaff's auscultatory proficiency. Setting: All accredited U.S. internal medicine and cardiology programs and nine university-affiliated internal medicine and cardiology programs. Participants: Four hundred ninety-eight (75.6%) of all 659 directors surveyed; 203 physicians-in-training and 49 third-year medical students. Interventions: Directors completed a 23-item questionnaire, and students and trainees were tested on 12 prerecorded cardiac events. Main Outcome Measures: The teaching and proficiency of cardiac auscultation at all levels of training. Results: Directors attributed great importance to cardiac auscultation and thought that more time should be spent teaching it. However, only 27.1% of internal medicine and 37.1% of cardiology programs offered any structured teaching of auscultation (P = 0.02). Programs without teaching were more likely to be large, university affiliated, and located in the northeast. The trainees' accuracy ranged from 0 to 56.2% for cardiology fellows (median, 21.9%) and from 2% to 36.8% for medical residents (median, 19.3%). Residents improved little with year of training and were never better than third-year medical students. Conclusions: A low emphasis on cardiac auscultation appears to have affected the proficiency of medical trainees. Our study raises concern about the future of this time-honored art and, possibly, other bedside diagnostic skills.
Possible morbidity in women from talc on condoms
Authors: C. S. Kasper
Journal: JAMA (1995)

<h3>In Reply.</h3> —OncorMed provides service for the early detection and treatment of cancer through molecular genetics. This service is provided through physicians, geneticists, and genetic counselors. We share Dr Vance's concerns that the public be educated as to the risks, benefits, advantages, and current limitations of genetic testing. Our marketing material, which is available to physicians and genetic counselors, reflects this concern. We agree with Vance that commercial companies should not be immune to technical and ethical responsibilities involved in genetic testing. All of the physicians and scientists at OncorMed come from academic backgrounds and retain academic affiliations. We work with physicians, bioethicists, medical geneticists, and patient advocates to assure that our services meet the highest standards of quality and integrity. We regret that Vance interprets our position otherwise or that any of our company information would create a difficulty for her or her associates in what is already a
The response of the renal and femoral vascular beds to coronary embolization in the dog
Authors: R. E. FALICOV, C. J. MILLS, I. T. GABE
Journal: Cardiovascular Research (1975)

Journal Article The response of the renal and femoral vascular beds to coronary embolization in the dog Get access RAUL E. FALICOV, RAUL E. FALICOV 1 From the MRC Cardiovascular Research Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 1Work carried out during tenure as John S. Guggenheim Foundation Fellow. Present address and address for reprints: The University of Chicago Hospitals, 950 East 59th Street, Chicago, Illinois, 60637, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar CHRISTOPHER J. MILLS, CHRISTOPHER J. MILLS From the MRC Cardiovascular Research Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 Search for other works by this author on: Oxford Academic PubMed Google Scholar IVOR T. GABE IVOR T. GABE From the MRC Cardiovascular Research Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 9, Issue 2, March 1975, Pages 151–160, https://doi.org/10.1093/cvr/9.2.151 Published: 01 March 1975
Continuous venovenous hemodiafiltration (CWHDF) with citrate anticoagulation in the treatment of a patient with acute renal failure, hypercalcemia, and thrombocytopenia
Authors: V. Šrámek, I. Novák, M. Matějovič, R. Rokyta, M. Nalos, P. Hora, H. Pittrová
Journal: Intensive Care Medicine (1998)
Chest Pain in Users of Video Display Terminals-Reply
Authors: Andrea Z. LaCroix
Journal: JAMA (1987)

In Reply.—  We are pleased to comment on the reanalysis of our data by Schnorr et al confirming the relationship of VDT use to chest pain among North Carolina telecommunications workers. Unfortunately, they have incorrectly summarized our reported findings. 1 Our investigation was restricted to 519 women employed as office workers, in contrast to the 827 subjects analyzed by Schnorr et al, which included both office workers and non—office workers. Chest pain symptomatology was classified by the London School of Hygiene Rose angina questionnaire. 2 We reported a twofold greater prevalence of angina among VDT users compared with nonusers (15.2% vs 7.7% [P =.01]), with VDT users defined as those using the VDT during half or more of their workday. We believe the lower prevalence rates reported by Schnorr et al (10.9% and 6.5% among VDT users and nonusers, respectively) are due to their inclusion of non—office workers in the
Family Records—A Plea for the Systematic Preservation of Exact Data—Answers Desired.
Authors: J. Madison Taylor
Journal: JAMA (1907)

1504Pine Street, Philadelphia, Aug. 23, 1907. <h3>To the Editor:</h3> —Historians are constantly hindered in their search for truth by the absence of exact records, especially as to the lives of individuals. Nowhere are these kept with completeness and exactitude. Even the courts of law, the county and municipal authorities, make only partial provision for the future in this particular. Even at the present enlightened time recourse is constantly had to the "family Bible," in which the custom prevails to place some account of births and deaths, which gives, at best, only names and ages, with possibly some fragmentary comments on acts. Clergymen do sometimes keep books containing registrations of marriages, births and baptisms, rendering a meager and irregular assistance. Old-time physicians were accustomed likewise to take account of some such data, also the more careful ones kept notes of illnesses. Not all physicians, even now, take careful notes of
New Zealand's Injury Prevention Research Unit: reducing sport and recreational injury.
Authors: D J Chalmers
Journal: British Journal of Sports Medicine (1994)

The Injury Prevention Research Unit was established in 1990 to reduce the incidence, severity and consequences of injury. Research into sport and recreational injury is one of five major areas of research being undertaken. National data sources have been used to estimate the overall size of the problem and to describe the nature and circumstances of injury associated with a variety of sport and recreational activities. Analytical studies are now being undertaken to identify significant risk and protective factors. Research activity is being directed toward the development, implementation and evaluation of preventive measures.
Hydrogen Sulfide Poisoning in a Hospital Setting
Authors: John W. Peters
Journal: JAMA (1981)

TOXICITY from hydrogen sulfide (H<sub>2</sub>S) has been experienced in industries involving petroleum refining, manufacturing of heavy water, tanning, vulcanization of rubber, manufacturing of rayon, and also in the fishing and refuse industries.<sup>1,2</sup>An episode of H<sub>2</sub>S poisoning occurred in an acute-care hospital, where H<sub>2</sub>S gas resulted from the reaction of a strong acid in an industrial cleaner with plaster of paris sludge in a cast room drain. <h3>Report of a Case</h3> A previously healthy 45-year-old man set out to clean the cast room drain trap of a community hospital with 90% sulfuric acid (H<sub>2</sub>SO<sub>4</sub>) solution. Previous efforts to clean the drain had been limited to mechanical means (snaking) because of the high sludge content. As the H<sub>2</sub>SO<sub>4</sub>solution was poured into the drain in a small basement cubicle, noxious fumes spread through the hospital and the workman
Direct Evidence of Nonuniform Distribution of Vagal Effects on Dog Atria
Authors: ISHIO NINOMIYA
Journal: Circulation Research (1966)

The duration of the monophasic action potential (APD), the interval between atrial beats and the delay time between excitation of the right and left atria of dogs were measured, using coaxial suction electrodes, before and during vagal stimulation. The effect of vagal stimulation on the degree of shortening of APD varied at different recording sites in the atrium, the shortening being more pronounced in the right than in the left atrium. Threshold and rate of recovery after cessation of stimulation varied throughout the atrium. The results indicate that the vagal effect is nonuniformly distributed over the atrium. The time difference between excitation of the right and left atria increased with vagal stimulation under the present experimental condition, suggesting that a reduction of synchrony of excitation occurred in the atrial myocardial fibers as a whole. The same conclusion was derived from analysis of the pattern of the P wave before and during vagal stimulation.
Clinical Tropical Diseases
Authors: Rodney C. Jung
Journal: JAMA (1961)

The authors frankly stated their aim in the preface to the first edition "to supply essential facts as dogmatically and concisely as we can." That they have succeeded in this aim makes this book perhaps the most useful, ounce for ounce, of textbooks in tropical medicine. The information in general is practical and clinically oriented. The scope is wide in view of the volume's small size. Coverage of Asian and African diseases seems somewhat more accurate than that of the American ones. Salmonellosis and South American blastomycosis are omitted. Some statements made unabashedly should certainly meet with disagreement; some will eventually prove to be incorrect. Since no references to literature are given, the book is not only dogmatic but also undocumented. While this was necessary to achieve the objective of the writers and the outcome is, in general, good, it does appear that the book might have been even more