Nephrotic Range of Proteinuria and Interferon Therapy
Authors: Kenneth S. Weiss
Journal: Annals of Internal Medicine (1992)

Letters15 February 1992Nephrotic Range of Proteinuria and Interferon TherapyKenneth S. Weiss, MDKenneth S. Weiss, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-4-347_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Nephrotic range proteinuria is a well-documented side effect of recombinant gamma interferon and all other interferons (1-3). The doses reported to cause this effect have been in the range of 0.25 mg/m2 to 1 mg/m2 body surface area (activity, 1 x 107 units per milligram of protein). I report a case of nephrotic-range proteinuria in a patient receiving therapy at a much lower dose.A 64-year-old man had wide excision and skin grafting for a Clark level-IV (11.2 mm-thick) malignant melanoma on his midback. He soon thereafter developed axillary adenopathy, consistent with metastatic melanoma. He agreed to...References1. BennettVogelzangRatain CNM. Severe toxicity (r-Ifn gamma) phase I trial of vinblastine (VLB) and recombinant gamma-interferon. Proc ASCO. 1986;5:223. Google Scholar2. SriskandianGarnerWatkinson KDJ. A toxicity study of recombinant interferon gamma given by intravenous infusion to patients with advanced cancer. Cancer Chemother Pharmacol. 1986;18:63-8. CrossrefMedlineGoogle Scholar3. GarnickReichRichie MSJ. Phase I/II study of interferon gamma (Immuneron) in advanced renal cell carcinoma (RCC) [Abstract]. J Urol. 1986;135:166A. Google Scholar4. SelbyKohnRaymond PJJ. Nephrotic syndrome during treatment with interferon [Letter]. Br J Med. 1985;290:1180. CrossrefMedlineGoogle Scholar5. SriskandianTeePettingale KDK. Nephrotic syndrome during treatment with interferon. Br Med J. 1985;290:1590-1. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kaiser Permanente Medical Center Cleveland, OH 44130 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedication-Associated Glomerular DiseaseMedication-Associated Glomerular DiseaseVascularite cutanée avec atteinte rénale compliquant un traitement par interféron bêta-1a pour une sclérose en plaquesNephrotoxicity of Interferon Alfa–Ribavirin Therapy for Chronic Hepatitis CINTERFERON-?? TREATMENT OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER IN RECIPIENTS OF SOLID ORGAN TRANSPLANTS1Thrombotic microangiopathy associated with alpha-interferon therapy for chronic myelocytic leukemiaInterferon-gamma (IFN-γ) and IL-4 expressed during mercury-induced membranous nephropathy are toxic for cultured podocytesNéphropathies secondaires aux interférons alpha: à propos de deux observationsMaladies auto-immunes et traitement par l'IFN-α: revue de la littérature à propos d'un cas d'hyperthyroïdieAntiviral drugsInterferon gamma 15 February 1992Volume 116, Issue 4Page: 347-347KeywordsBody surface areaInterferonsMelanomaMembrane proteinsProteinuriaSkin grafting Issue Published: 15 February 1992 PDF downloadLoading ...