tbuckley/cabot-search huggingface dataset:
The broader impact of walking to school among adolescents: seven day accelerometry based study
Authors: Leslie M Alexander, Jo Inchley, Joanna Todd, Dorothy Currie, Ashley R Cooper, Candace Currie
Journal: BMJ (2005)

differences in blood lipids, insulin, and leptin persist with increasing age these could be of public health importance.As the provision of school dinners has changed little in the past five years, 1 the differences could be of continuing relevance.However, the extent to which the differences reflect dissimilarities in the composition of school dinners and home provided school meals or other aspects of the dietary patterns and health behaviours of the two groups remains uncertain.Despite these uncertainties, we can draw two general conclusions.Firstly, the lower mean folate concentration seen among pupils eating school dinners suggests that new initiatives likely to increase the folate content of school dinners would be appropriate. 5 Secondly, the other differences seen suggest that the average health status of pupils eating school dinners is no worse-and may actually be better-than that of pupils eating meals provided from home.This suggests that efforts to improve the diet and nutrition of British children and adolescents will need to extend beyond school dinners to tackle overall dietary patterns and their societal determinants if they are to be successful.We are grateful to the research team members and to the participating schools and pupils.We thank P M Ueland and H Refsum (department of pharmacology, University of Bergen) for the measurement of serum folate.
GRAVE ABDOMINAL INJURIES WITHOUT EXTERNAL EVIDENCES OF TRAUMATISM.
Authors: R. HARVEY REED
Journal: JAMA (1902)

It has been my privilege during the last twenty years to have met with a class of grave abdominal injuries which has given little or no external evidences of traumatism. The patient in each instance has given a history of a severe injury which resulted in death in from 24 hours to 26 days after the traumatism. I will only report three of these cases in detail, as the others were practically duplicates and to make a full report would only take up valuable time without special advantage. The first of these cases which came to my notice occurred about fifteen years ago, in an unusually large, healthy man of some 36 years of age, who had charge of a planing mill in Crestline, Ohio. At the time the accident occurred, he was engaged in sawing palings with a buzz-saw. These palings were about three feet in length, some two
FDA raises concerns about ultra-long acting insulins given green light in Europe and Japan
Authors: I. Torjesen
Journal: BMJ (2012)

The US drug regulator has announced that it intends to take a close look at the cardiovascular safety of the ultra-long acting insulin degludec next week, because data had indicated that the drug was associated with “an excess risk for cardiovascular events” in comparison with other insulins, it said.

The Food and Drug Administration will assess the safety and efficacy of two products, insulin degludec (marketed as Tresiba) and the combination of insulin degludec and insulin aspart (Ryzodeg) for the treatment of type 1 and type 2 diabetes mellitus at a meeting on 8 November.

A document published by the FDA committee ahead of this meeting said, “This meeting will focus on the cardiovascular safety of two products, insulin degludec/insulin aspart [rDNA origin] and insulin degludec [rDNA origin], as meta-analyses …
RS3PE and ovarian cancer
Authors: M VINCI
Journal: Annals of the Rheumatic Diseases (2001)

A variety of rheumatological diseases are associated with malignancies; among these polymyositis-dermatomyositis, carcinomatous polyarthritis, and palmar fasciitis are the most common.1 2 Other associated diseases include reflex algoneurodystrophy—that is, shoulder-hand syndrome or Sudeck's atrophy. In 1985 a syndrome characterised by tenosynovitis of the sheaths of the tendons of hands, symmetrical distal synovitis, pitting oedema over the hand dorsum and the feet (less commonly over the pretibial region), and rheumatoid factor seronegativity was described.3 This syndrome, with generally benign prognosis, was reported during the 1990s, but only in 1994 were clinical criteria for diagnosis proposed.4 In a few cases this syndrome was associated with malignancies: one with endometrial adenocarcinoma, two with gastric carcinoma, four with prostatic carcinoma, and one with colic carcinoma.5-7 We report the case of a woman affected by remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) and concurrent ovarian carcinoma.

### CASE REPORT

In January 1995 a 69 year old woman was admitted to our institute with severe pain and stiffness of the shoulders, hips, and ankles lasting up to two months, which did not respond to cortisone (prednisone 15 mg/day). Laboratory findings showed inflammation was increased and tumour markers were all negative. Table 1 reports the laboratory data. Erythrocyte sedimentation rate, C reactive …
Court Intervention and the Diminution of Patients' Rights: The Case of Brother Joseph Fox
Authors: John J. Paris
Journal: New England Journal of Medicine (1980)

Quinlan, Saikewicz, Spring, Fox — names announced in headlines and flashed on TV screens — were patients whose terminal illnesses were removed from the privacy of the family and made the subject matter of protracted legal battles. Their cases raise anew the question of the court's role in termination of life-supporting treatments. The most recent of these cases, that of Brother Joseph Fox, is one of the most unsettling.Fox was an 83-year-old religious brother from Chaminade High School in Mineola, N.Y., who entered Nassau Hospital for a routine hernia operation. During the course of that operation, he had severe . . .
Telemetric Monitoring of the Electrocardiogram in Acute Myocardial Infarction.
Authors: Arthur Bernstein
Journal: Annals of Internal Medicine (1965)

s1 November 1965Telemetric Monitoring of the Electrocardiogram in Acute Myocardial Infarction.Arthur Bernstein, M.D., Edwin L. Rothfeld, M.D., Victor Parsonnet, M.D., I. R. Zucker, M.D.Arthur Bernstein, M.D.Search for more papers by this author, Edwin L. Rothfeld, M.D.Search for more papers by this author, Victor Parsonnet, M.D.Search for more papers by this author, I. R. Zucker, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-908_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA relay telemetric system has been developed for the continuous long term recording and monitoring of the electrocardiogram in patients with acute myocardial infarction. We feel that this apparatus is superior to other devices because it frees the patient from all mechanical and electrical contrivances that could contribute to his anxiety and discomfort. In essence, the system consists of a transistorized transmitter attached to the patient and a receiver designed to record the date on a dual-channel magnetic tape. The receiver has an arrhythmia detector sensitive to any change in R-R interval or R wave amplitude.We have monitored 32... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Newark, New Jersey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 908-908KeywordsAcute myocardial infarctionAnxietyArrhythmiaElectrocardiography Issue Published: 1 November 1965 PDF downloadLoading ...
Role of basic fibroblast growth factor in vascular lesion formation.
Authors: V Lindner, D A Lappi, A Baird, R A Majack, M A Reidy
Journal: Circulation Research (1991)

In the present study we investigated whether basic fibroblast growth factor (bFGF) plays a role in the proliferative response of smooth muscle cells (SMCs) to denuding injury. Rat carotid smooth muscle was found to express the mRNA for bFGF, and bFGF protein was found to be present in rat aorta by immunoblot analysis. Systemically administered bFGF was a potent mitogen for vascular SMCs in arteries denuded with a balloon catheter, increasing replication from 11.5% in controls to 54.8%. Denudation with a device (filament loop), which causes only minimal damage to medial SMCs, showed a similar increase in replication (1.3% versus 43.3%) after bFGF infusion. In unmanipulated vessels, however, SMCs were unresponsive to infused bFGF. Infusion of a "mitotoxin" (bFGF conjugated to saporin) caused a greater than 50% decrease in the number of viable SMCs in the arterial wall after balloon injury. Prolonged administration of bFGF (12 micrograms/day for 2 weeks) after balloon injury caused an approximately twofold increase in intimal thickening. These results show that bFGF, which is synthesized by the arterial wall, could be a potent mitogen for SMCs in vivo and suggest that any release of endogenous bFGF may be capable of stimulating SMC proliferation, which may subsequently lead to intimal lesion formation.
Enhancement of Hematopoietic Uptake by Granulocyte Colony-Stimulating Factor in Ga-67 Scintigraphy
Authors: HIROSHI KONDOH, SHIGEYUKI MURAYAMA, TAKAHIRO KOZUKA, TSUNEHIKO NISHIMURA
Journal: Clinical Nuclear Medicine (1995)

The authors report on two non-Hodgkin's lymphoma cases which showed markedly enhanced Ga-67 uptake of granulopoietlc area induced by recombinant human granulocyte colony-stimulating factor (rhG-CSF) administration. The rhG-CSF is a newly developed agent for reduction of infections, which stimulates the proliferation and differentiation of granulopoiesis. Use of rhGCSF is becoming increasingly frequent because the indications are so broad that most patients with intensive chemotherapy for malignancies benefit from undergoing this treatment. In this study, the results of the two cases were: 1) G-CSF enhanced the accumulation of Ga-67 citrate in the granulopoietic area; 2) the marked uptake of red marrow looked like involvement; and 3) in contrast, the involved area became relatively "cold." These findings should be considered in the interpretation of Ga-67 scintigraphy.
Food-Borne Infections and Intoxications.
Authors: J. Glenn Morris, Morris E. Potter
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hydantoins in the Treatment of Epilepsy
Authors: Matthew T. Moore
Journal: JAMA (1961)

<h3>To the Editor:—</h3> I wish to commend Drs. Low and Yahr<sup>1</sup>for their study in pursuing the pulmonary changes which may occur incidental to the use of hydantoin preparations in the treatment of epilepsy. To avoid any possible misinterpretation of the text of my article<sup>2</sup>it would be appropriate to correct the inference in the second paragraph of their article. In my series, all of the patients in whom roentgenographic evidence of pulmonary changes was found were asymptomatic. The x-ray changes in 4 of the cases, in which the radiologist reported "pulmonary fibrosis" or "increased bronchovascular markings," were fortuitous findings. At no time during the study was the hydantoin preparation discontinued since it was felt that, whatever the pulmonary change might be, it evidently was innocuous as well as asymptomatic. To deprive epileptics of the use of diphenylhydantoin would constitute a serious blow to the treatment of this
Response to Wang et al.
Authors: D. Altshuler
Journal: Journal of Clinical Investigation (2005)

We appreciate the opportunity to correct a typographical error in our commentary (1) “MEF2A sequence variants and coronary heart disease: a change of heart?”. Specifically, the number of nonsynonymous changes found in controls should have read “1 in 500,” not “0 in 500” as in our published article. (This is because the 21-nt deletion was seen in controls.) Based on the then-available counts (5/500 in cases and 1/500 in controls), the 2-tailed P value we provided (P > 0.2) is correct.

The accompanying letter from Weng et al. adds to and clarifies their recent study (2), providing more detailed information about ascertainment of variants in cases and controls. First, all exons were resequenced in cases, but only certain exons were resequenced in controls. Second, several additional missense changes were identified in both cases and controls. Taking these data into account, it appears that there have been 7 missense changes identified in cases and 5 in controls, including 3 found uniquely in cases, 1 found uniquely in controls, and 4 found in both groups. Moreover, the incomplete ascertainment in controls by Weng et al. (2) means that the current estimate of the frequency of MEF2A missense mutations in controls is a lower bound; additional missense changes in controls (which might have been found by more complete resequencing) would shift the combined data in the direction away from association between MEF2A variation and cardiac disease.

Finally, we note that the major prevailing bias in the association literature is publication bias; that is, there is a greater likelihood that positive claims of association will be published as compared with studies that provide no evidence of association (3). Counteracting this bias requires that we encourage the publication and dispassionate evaluation of all relevant data, whether or not the data support an association.
Comprehensive Health Care for the Elderly
Authors: Albert A. Fisk
Journal: JAMA (1983)

Health care for the elderly in the United States remains fragmentary and noncomprehensive despite concern for the needs of an expanding elderly population and a new emphasis on geriatrics. Model health care programs for the elderly have been few and not generally applicable to central city populations. A model health care program has been designed to offer a continuum of comprehensive, multidisciplinary health care to Milwaukee elderly. An acute care unit for the elderly, rehabilitation-oriented nursing home, outpatient clinic, home care service, outreach clinics, rehabilitation day hospital, Alzheimer's Disease Day Care program, and acute geriatric psychiatric unit have been developed and integrated into one continuum of care. The program serves chiefly the frail elderly, who are demonstrated to be markedly impaired physically, mentally, and socially, requiring the services of multiple professionals to enable the patients to achieve maximum independence. Alternatives to institutionalization are emphasized, and geriatric education and research programs are part of the model program.
S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: A study with isolated and perfused rat liver
Authors: R N Cincu, C M Rodriguez-Ortigosa, I Vesperinas, J Quiroga, J Prieto
Journal: Hepatology (1997)

Cysteinyl-leukotrienes can cause cholestasis and liver damage when administered at nanomolar concentrations. Using the isolated and perfused rat liver we analyzed whether S-adenosyl-L-methionine (SAMe) may protect this organ against the noxious effects of leukotriene-D4 (LTD4). We observed that a 2 nmol bolus of this compound decreased bile flow (-12.6% ± 1.6%, P &lt; .02), and bile salt excretion (-23.5% ± 2.2%, P &lt; .02; both compared with baseline values), caused the release of glutamic-oxaloacetic transaminase (GOT) and lactic dehydrogenase (LDH) to the hepatic effluent, and increased significantly the perfusion pressure as compared with a control group not receiving LTD4 (6.0 ± 1.1 vs. 0.2 ± 0.02 mm hg, respectively; P &lt; .001). The cholestatic effect of LTD4 was attenuated by infusion of SAMe which, at rates of 67 and 100 microg/min, totally prevented the decrease in bile salt excretion. Likewise, in SAMe infused livers, the release to the effluent of GOT and LDH was lower than in the group receiving LTD4 only, and was even lower than in the control group. We also found that the increase in perfusion pressure induced by LTD4 was prevented by SAMe in a dose-dependent manner. Of interest, SAMe increased the biliary excretion of the eicosanoid in a dose-related fashion. We conclude that SAMe reverts the cholestatic, cytotoxic, and hemodynamic effects of LTD4 on the liver, and that these protective effects might be partly because of a stimulation of the biliary excretion of the leukotriene.
Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation
Authors: Hana Raslova, Véronique Baccini, Lamya Loussaief, Béatrice Comba, Jérôme Larghero, Najet Debili, William Vainchenker
Journal: Blood (2005)
1088-122 Augmentation of glucose metabolism with perhexilline improves maximal oxygen consumption and quality of life in patients with nonischaemic dilated cardiomyopathy
Authors: Leong Lee, Ross Campbell, Rachel Field, Prasad Gunaruwan, Justin Taylor, Matthias Schmitt, John Horowitz, Michael Frenneaux
Journal: Journal of the American College of Cardiology (2004)
Man Versus Woman
Authors: CHARLES D. ARING
Journal: Annals of Internal Medicine (1970)

Perspective1 December 1970Man Versus WomanA Historical and Cultural FrameworkCHARLES D. ARING, M.D.CHARLES D. ARING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-6-1025 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe female woman is one of the greatest institooshuns of which this land can boste.—ARTEMUS WARD, Women's RightsWhen all roads led to Rome they nourished the heart of empire. Today, their far-flung facsimiles quicken the mindless miles. But often enough they degrade rather than nurture. Their noxiousness occasions wonder whether it might not be better at times to proceed more deviously and less directly by road and with more direction than deviousness in human affairs, if this is a choice needing to be made.One more highway, built to connect two arms of an asphalt octopus, wreaked desolation... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES D. ARING, M.D.Affiliations: Cincinnati, Ohio▸From the Department of Neurology, University of Cincinnati College of Medicine and the Cincinnati General Hospital, Cincinnati, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1970Volume 73, Issue 6Page: 1025-1031KeywordsHeartHospital medicineNeurology ePublished: 1 December 2008 Issue Published: 1 December 1970 PDF downloadLoading ...
Failure to Diagnose Acute Myocardial Infarction
Authors: Richard M. Zoraster
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The article written by Zarling and associates entitled "Failure to Diagnose Acute Myocardial Infarction" discussed the specialty of the responsible physician with respect to missing the diagnosis. They state that "among the non-internal medicine specialists, the diagnostic accuracy in class I was 0%." The definition of class I was "typical retrosternal chest pain with confirmatory enzymatic and/or ECG findings." When inspecting Table 3 included in the referenced article, we noted that there were no patients in class I for this group; therefore, the calculation of 0/0=0% is misleading. Another interpretation is that there was 100% accuracy in this group and, while no myocardial infarctions with "typical presentations" were missed by non-internal medicine physicians, the internists missed three of 27, or 11%.
The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma
Authors: Shwetal Mehta, Emmanuelle Huillard, Santosh Kesari, Cecile L. Maire, Diane Golebiowski, Emily P. Harrington, John A. Alberta, Michael F. Kane, Matthew Theisen, Keith L. Ligon, David H. Rowitch, Charles D. Stiles
Journal: Cancer Cell (2011)
Investigation of keratinocyte regulation of collagen I synthesis by dermal fibroblasts in a simple<i>in vitro</i>model
Authors: C.A. Harrison, F. Gossiel, A.J. Bullock, T. Sun, A. Blumsohn, S. Mac Neil
Journal: British Journal of Dermatology (2005)

Background Hypertrophic scarring and skin graft contracture are major causes of morbidity after burn injuries. A prominent feature is excessive fibroplasia with accumulation of increased fibrillar collagen relative to normal scar tissue. The application of split‐thickness skin grafts or cultured epithelial autografts to burn wounds is known to reduce scarring and contraction.
Nerve Conduction Velocity-Reply
Authors: Ernest W. Johnson
Journal: JAMA (1961)

To the Editor:—  Dr. Hodes' premise is that the conduction velocity of motor fibers in poliomyelitis patients is reduced, presumably because of selective destruction of large motor neurons. This premise was based on determinations in 26 chronic patients (presumptive diagnosis).  Our position is that the conduction velocity in poliomyelitis patients is within normal limits if correction is made for reduced temperatures. Our conclusion was based on a study of 96 patients with acute poliomyelitis (within 6 months of the onset). In 53 of these patients, diagnosis was made with stool isolation of virus or a rise in antibodies in the convalescent sera.  Dr. Hodes cites (out of context) 2 of our cases to show that we demonstrated reduced velocities, but he does not mention that these were unilateral in cool extremities in which the reduction in velocity corresponded to the reduction in temperature as compared with thenoninvolvedextremities—further proof
Ocular Damage in the Battered-baby Syndrome
Authors: A. S. Mushin
Journal: BMJ (1971)

Twelve out of 19 battered babies seen with ocular damage have permanent impairment of vision affecting one or both eyes. Ocular disease, especially retinal haemorrhage, is common in the battered-baby syndrome, and infants with this condition should always have a complete ophthalmic examination.
Lifebox: give a little, help a lot
Authors: I. H. Wilson, I. A. Walker
Journal: BMJ (2012)

In the 1980s pulse oximetry transformed the safety of anaesthesia in UK. For the first time anaesthetists in operating theatres could determine the oxygenation of unconscious patients accurately, rather than trying to estimate skin colour under green drapes with artificial light. Since most preventable deaths under anaesthesia involve hypoxia or hypotension, all UK hospitals purchased oximeters, and they rapidly became a universal standard. Initially oximeters were used in theatre, the anaesthetic room, and recovery but they rapidly spread to all areas of the hospital. Today arterial oxyhaemaglobin saturation (SpO2) is recorded almost as routinely as heart rate and blood pressure.

Anaesthesia in the UK is well resourced and safe, with mortality directly attributable to anaesthesia of around 1 in 200 000. The situation is completely different in poorer settings, where the mortality directly attributable to anaesthesia has …