Hypoxia in Polycythemia Vera
Authors: M. LERTZMAN
Journal: Annals of Internal Medicine (1964)

Article1 March 1964Hypoxia in Polycythemia VeraM. LERTZMAN, M.D., B. M. FROME, M.D., L. G. ISRAELS, M.D., R. M. CHERNIACK, M.D., F.A.C.P.M. LERTZMAN, M.D.Search for more papers by this author, B. M. FROME, M.D.Search for more papers by this author, L. G. ISRAELS, M.D.Search for more papers by this author, R. M. CHERNIACK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-3-409 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is generally considered that the demonstration of arterial oxygen unsaturation in a patient with polycythemia indicates a secondary rather than a primary cause for the increase in red cell mass (1-3). While hypoxia has been demonstrated in some patients with polycythemia vera (4-6) it has been attributed in these instances to co-existent cardiorespiratory disease (1, 6) or aging (7).The present study demonstrates that the arterial oxygen tension may be low in patients with polycythemia vera who have no demonstrable co-existent cardiorespiratory disease and presents evidence that the hypoxia may be the result of an abnormality of the pulmonary...References1. FISHERBEDDELLSEEBOHM JHGNPM: Differentiation of polycythemia vera and secondary polycythemia by arterial oxygen saturation and pulmonary function tests. J. Lab. Clin. Med. 50: 455, 1957. MedlineGoogle Scholar2. RATTOBRISCOECOMROEMORTON OWAJHJW: Anoxemia secondary to polycythemia and polycythemia secondary to anoxemia. Amer. J. Med. 19: 958, 1955. CrossrefMedlineGoogle Scholar3. WASSERMANDOBSONLAWRENCE LRRLJH: Blood oxygen studies in patients with polycythemia and in normal subjects. J. Clin. Invest. 28: 60, 1949. CrossrefMedlineGoogle Scholar4. LAWRENCE JH: Polycythemia. Physiology, Diagnosis and Treatment, Modern Medical Monographs. Grune and Stratton, New York, 1955. Google Scholar5. CASSELSMORSE DRM: The arterial blood gases, the oxygen dissociation curve, and the acid-base balance in polycythemia vera. J. Clin. Invest. 32: 52, 1953. CrossrefMedlineGoogle Scholar6. NEWMANFELTMANDEVLIN WAJAB: Pulmonary function studies in polycythemia vera. Amer. J. Med. 11: 706, 1951. CrossrefMedlineGoogle Scholar7. GRIEFENSTEINKINGLATCHCOMROE FERMSSJH: Pulmonary function studies in healthy men and women 50 years and older. J. Appl. Physiol. 4: 641, 1952. CrossrefMedlineGoogle Scholar8. WINTROBE MM: Clinical Hematology. Lea & Febiger, Philadelphia, 1961. Google Scholar9. MACGOVERNJONESSTEINBERG JJARAG: Hematocrit of capillary blood. New Eng. J. Med. 253: 308, 1955. CrossrefMedlineGoogle Scholar10. STORASLIKRIEGERFRIEDELLHOLDEN JPHHLWP: Use of radioactive iodinated plasma protein in study of blood volume. Surg. Gynec. Obstet. 91: 458, 1950. MedlineGoogle Scholar11. GIBSONEVANS JGWA: Clinical studies of the blood volume. 2. The relation of plasma and total blood volume to venous pressure, age and sex in ninety normal humans. J. Clin. Invest. 317: 16, 1937. Google Scholar12. STERLINGGRAY KSJ: Circulating red cell volume in man by radioactive chromium. J. Clin. Invest. 92: 1614, 1950. CrossrefGoogle Scholar13. CHAPLINMOLLISONVETTER HPLH: The body/venous hematocrit ratio: its constancy over a wide hematocrit range. J. Clin. Invest. 32: 1309, 1953. CrossrefMedlineGoogle Scholar14. LERTZMANJOHNSONMAMACOS MRJP: Unpublished data. Google Scholar15. BALDWINCOURNANDRICHARDS EDADW: Pulmonary insufficiency. I. Physiological classification, clinical methods of analysis, standard values in normal subjects. Medicine 27: 243, 1948. CrossrefMedlineGoogle Scholar16. LEUALLENFOWLER ECWS: Maximal mid-expiratory flow. Amer. Rev. Tuberc. 72: 783, 1955. Google Scholar17. COURNANDBALDWINDARLINGRICHARDS AEDRCDW: Studies on intrapulmonary mixture of gases. 1. The significance of the pulmonary emptying rate and a simplified open circuit measurement of residual air. J. Clin. Invest. 20: 681, 1941. CrossrefMedlineGoogle Scholar18. BRINKMANJOHNSDONOSORILEY GLCJHRL: A modification of the method of Riley, Proemmel and Franke for determination of oxygen and carbon dioxide tensions in blood. J. Appl. Physiol. 7: 340, 1954. CrossrefMedlineGoogle Scholar19. RILEYPROEMMELFRANKE RLDDRE: A direct method for determination of oxygen and carbon dioxide tension in blood. J. Biol. Chem. 161: 621, 1945. CrossrefMedlineGoogle Scholar20. SEVERINGHAUSBRADLEY JWAF: Electrodes for blood pO2 and pCO2 determinations. J. Appl. Physiol. 13: 515, 1958. CrossrefMedlineGoogle Scholar21. VAN SLYKENEILL DDJM: The determination of gases in blood and other solutions by vacuum extraction and manometric measurements. J. Biol. Chem. 61: 523, 1924. CrossrefGoogle Scholar22. SCHOLANDER PF: Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. Ibid., p. 235. Google Scholar23. BATESWOOLFPAUL DVCRGI: Chronic Bronchitis. Med. Serv. J. Canada 18: 211, 1962. MedlineGoogle Scholar24. FILLEYMACINTOSHWRIGHT GFDJGW: Carbon monoxide uptake and pulmonary diffusing capacity in normal subjects at rest and during exercise. J. Clin. Invest. 33: 530, 1954. CrossrefMedlineGoogle Scholar25. CHERNIACKCHERNIACK RML: Respiration in Health and Disease. W. B. Saunders Co., Philadelphia, 1961. Google Scholar26. RANKINMCNEILLFORSTER JRSRE: Diffusion characteristics of the pulmonary membrane and capillary bed in various diseases of the lungs and cardiovascular system. J. Clin. Invest. 35: 922, 1957. Google Scholar27. HARROPHEATH GAEH: Pulmonary gas diffusion in polycythemia vera. J. Clin. Invest. 4: 53, 1927. CrossrefMedlineGoogle Scholar28. Combined Staff Clinic Polycythemia. Amer. J. Med. 24: 132, 1958. MedlineGoogle Scholar29. FORSTER RE: Exchange of gases between alveolar air and pulmonary capillary blood: pulmonary diffusing capacity. Physiol. Rev. 37: 391, 1957. CrossrefMedlineGoogle Scholar30. BURGESSBISHOP JHJM: Pulmonary diffusing capacity and its subdivisions in polycythemia vera. J. Clin. Invest. 42: 997, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. LERTZMAN, M.D.; B. M. FROME, M.D.; L. G. ISRAELS, M.D.; R. M. CHERNIACK, M.D., F.A.C.P.Affiliations: Winnipeg, Manitoba,From the Departments of Medicine and Pediatrics, the University of Manitoba, and the Winnipeg General Hospital, Winnipeg, Manitoba, Canada.This work was supported by grants from the Medical Research Council of Canada, the American Thoracic Society, the Manitoba Heart Association, and the National Cancer Institute of Canada.Requests for reprints should be addressed to M. Lertzman, M.D., the Children's Hospital of Winnipeg, 685 Bannatyne Avenue, Winnipeg 3, Manitoba, Canada. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnesthesia for polycythemia veraSpezielle Pathophysiologie der AtmungPolyglobulie und Polycythaemia veraPolycythemia: Erythrocytosis and ErythremiaWILLIAM N. VALENTINE, M.D., F.A.C.P., THOMAS G. HENNESSY, M.D., EUGENE LANG, M.D., ROBERT LONGMIRE, M.D., ROBERT MCMILLAN, M.D., WILLIAM ODELL, M.D., F.A.C.P., JOSEPH F. ROSS, M.D., F.A.C.P., JAMES L. SCOTT, M.D., F.A.C.P., DANIEL H. SIMMONS, M.D., PH.D., F.A.C.P., KOUICHI R. TANAKA, M.D., F.A.C.P.Cor PulmonaleClassification of Polycythemic Disorders With Comments on the Diagnostic Value of Arterial Blood Oxygen AnalysisJOHN F. MURRAY, M.D.Die Differentialdiagnose der Erythrocyth�mien durch Untersuchung der Ferround Erythrocytenkinetik mit radioaktivem Eisen und Chrom 1 March 1964Volume 60, Issue 3Page: 409-417KeywordsAgingHeartHospital medicineHypoxiaOxygenPediatricsPolycythemiaPolycythemia veraPulmonary diseasesVentilation perfusion ePublished: 1 December 2008 Issue Published: 1 March 1964 PDF downloadLoading ...