Coombs'-positive Hemolytic Anemia in Hodgkin's Disease
Authors: ERIC EISNER
Journal: Annals of Internal Medicine (1967)

Article1 February 1967Coombs'-positive Hemolytic Anemia in Hodgkin's DiseaseERIC EISNER, M.D., ALLYN B. LEY, M.D., KLAUS MAYER, M.D., F.A.C.P.ERIC EISNER, M.D.Search for more papers by this author, ALLYN B. LEY, M.D.Search for more papers by this author, KLAUS MAYER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-2-258 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAnemia, more or less severe in intensity, occurs in the course of nearly all cases of Hodgkin's disease. Although the dominant defect is usually one of insufficient red cell production, a decreased erythrocyte life-span has been demonstrated in a number of studies (1-5); indeed, a recent report (6) suggests that a significantly shortened red cell survival is characteristic of the advanced stages of the disease. The mechanism of this increased rate of cell destruction is not known. The classical manifestations of hemolytic anemia are scant or absent. Evidences of markedly increased hemoglobin catabolism and of intense erythropoiesis are usually not...References1. BROWN GM: Pathogenesis of secondary anaemias. Canad. Med. Ass. J. 62: 472, 1950. MedlineGoogle Scholar2. HYMAN GA: Studies on anemia of disseminated malignant neoplastic disease. I. Hemolytic factor. Blood 9: 911, 1954. CrossrefMedlineGoogle Scholar3. VERLOOP MC: Anaemia in systemic diseases. Acta Med. Scand. 151: 367, 1955. CrossrefMedlineGoogle Scholar4. GIANNOPOULOSBERGSAGEL PPDE: The mechanism of anemia associated with Hodgkin's disease. Blood 14: 856, 1959. CrossrefMedlineGoogle Scholar5. DESFORGESROSSMOLONEY JFJDWC: Mechanisms of anemia in leukemia and malignant lymphoma. Amer. J. Med. 28: 69, 1960. CrossrefMedlineGoogle Scholar6. CLINEBERLIN MJNI: Anemia in Hodgkin's disease. Cancer 16: 526, 1963. CrossrefMedlineGoogle Scholar7. SINGERDAMESHEK KW: Symptomatic hemolytic anemia. Ann. Intern. Med. 15: 544, 1941. LinkGoogle Scholar8. BROWNMEYNELL RJMJ: Haemolytic anaemia associated with Hodgkin's disease. Lancet 2: 835, 1949. CrossrefGoogle Scholar9. WILCOX DR: Haemolytic anaemia and reticuloses. Brit. Med. J. 1: 1322, 1952. CrossrefMedlineGoogle Scholar10. WASSERMANSTATSSCHWARTZFUDENBERG LRDLH: Symptomatic and hemopathic hemolytic anemia. Amer. J. Med. 18: 961, 1955. CrossrefMedlineGoogle Scholar11. KYLEKIELYSTICKNEY RAJMJM: Acquired hemolytic anemia in chronic lymphocytic leukemia and the lymphomas. Arch. Intern. Med. (Chicago) 104: 61, 1959. CrossrefGoogle Scholar12. METTIER SR: Classification and treatment of the hemorrhagic states. JAMA 108: 83, 1937. CrossrefGoogle Scholar13. JAVIDHOROWITZ JHI: An improved technic for the quantitation of serum haptoglobin. Amer. J. Clin. Path. 34: 35, 1960. CrossrefMedlineGoogle Scholar14. EVANSDUANE RSRT: Acquired hemolytic anemia. I. The relation of erythrocyte antibody production to activity of the disease. II. The significance of thrombocytopenia and leukopenia. Blood 4: 1196, 1949. CrossrefMedlineGoogle Scholar15. EVANSTAKAHASHIDUANEPAYNELIN RSKRRC: Primary thrombocytopenic purpura and acquired hemolytic anemia. Evidence for a common etiology. Arch. Intern. Med. (Chicago) 87: 48, 1951. CrossrefGoogle Scholar16. DAUSSETCOLOMBANI JJ: The serology and the prognosis of 128 cases of autoimmune hemolytic anemia. Blood 14: 1280, 1959. CrossrefMedlineGoogle Scholar17. DACIE JV: The Haemolytic Anaemias, Congenital and Acquired. Part III. The Auto-Immune Haemolytic Anaemias, 2nd ed. Grune & Stratton, Inc., New York, 1962, p. 378. Google Scholar18. CROSBYRAPPAPORT WHH: Autoimmune hemolytic anemia. I. Analysis of hematologic observations with particular reference to their prognostic value. A survey of 57 cases. Blood 12: 42, 1957. CrossrefMedlineGoogle Scholar19. FUDENBERGBARRYDAMESHEK HHIW: The erythrocyte-coating substance in autoimmune hemolytic disease; its nature and significance. Blood 13: 201, 1958. CrossrefMedlineGoogle Scholar20. EVANSBINGHAMBOEHNI RSMP: Autoimmune hemolytic disease. Antibody dissociation and activity. Arch. Intern. Med. (Chicago) 108: 338, 1961. CrossrefMedlineGoogle Scholar21. CONSTANTOULAKISCOSTEASCHWARTZDAMESHEK MNRSW: Quantitative studies of the effect of red-blood-cell sensitization on in vivo hemolysis. J. Clin. Invest. 42: 1790, 1963. CrossrefMedlineGoogle Scholar22. EVANSWEISER RSRS: The serology of autoimmune hemolytic disease. Arch. Intern. Med. (Chicago) 100: 371, 1957. CrossrefGoogle Scholar23. ULTMANN JE: The role of the spleen in the hemolytic anemia of cancer patients. Cancer Res. 18: 959, 1958. MedlineGoogle Scholar24. RICHMONDLEY JAB: Unpublished observations. Google Scholar25. BRUSLEWIS ISM: The haptoglobin content of serum in haemolytic anaemia. Brit. J. Haemat. 5: 348, 1959. CrossrefMedlineGoogle Scholar26. OWENDEGRUCHYSMITH JAGCH: Serum haptoglobins in haemolytic states. J. Clin. Path. 13: 478, 1960. CrossrefMedlineGoogle Scholar27. NYMAN M: Serum haptoglobin: methodological and clinical studies. Scand. J. Clin. Lab. Invest. 11 (suppl. 39): 1, 1959. MedlineGoogle Scholar28. WHITTEN CF: Studies on serum haptoglobin: a functional inquiry. New Eng. J. Med. 266: 529, 1962. CrossrefMedlineGoogle Scholar29. AISENBERG AC: Hodgkin's disease—prognosis, treatment and etiologic and immunologic considerations. New Eng. J. Med. 270: 508, 565, 617, 1964. CrossrefMedlineGoogle Scholar30. JELLIFFENABARRO AMJD: Corticosteroids in the treatment of reticuloses. Brit. J. Radiol. 34: 577, 1961. CrossrefMedlineGoogle Scholar31. SIEVERSHARWERTH KHG: Zur therapie symtomatischer hämolytischer anämien. Acta Hemat. (Basel) 9: 208, 1953. CrossrefMedlineGoogle Scholar32. BOVE JR: Combined erythroid hypoplasia and symptomatic hemolytic anemia. Report of a case. New Eng. J. Med. 255: 135, 1956. CrossrefMedlineGoogle Scholar33. ROUSSELOTRELLAROTTINO LMAJA: Splenectomy for hypersplenism in Hodgkin's disease. A reappraisal. Amer. J. Surg. 103: 769, 1962. CrossrefGoogle Scholar34. JANDL JH: Current concepts in therapy. Hemolytic anemia. New Eng. J. Med. 268: 482, 1963. CrossrefMedlineGoogle Scholar35. LEWISSCHWARTZDAMESHEK FBRSW: X-radiation and alkylating agents as possible "trigger" mechanisms in the autoimmune complications of malignant lymphoproliferative disease. Clin. Exp. Immun. 1: 3, 1966. MedlineGoogle Scholar36. KAPLANSMITHERS HSDW: Auto-immunity in man and homologous disease in mice in relation to the malignant lymphomas. Lancet 2: 1, 1959. CrossrefMedlineGoogle Scholar37. TYLER A: Clues to the etiology, pathology, and therapy of cancer provided by analogies with transplantation disease. J. Nat. Cancer Inst. 25: 1197, 1960. MedlineGoogle Scholar38. GREENINKELASALLEN IMLB: Hodgkin's disease: a maternal-to-foetal lymphoid chimera? Lancet 1: 30, 1960. CrossrefGoogle Scholar39. SCHWARTZCOSTEA RSN: Autoimmune hemolytic anemia: clinical correlations and biological implications. Seminars Hemat. 3: 2, 1966. MedlineGoogle Scholar40. SCHWARTZBELDOTTI RSL: Malignant lymphomas following allogenic disease: transition from an immunological to a neoplastic disorder. Science 149: 1511, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERIC EISNER, M.D.; ALLYN B. LEY, M.D.; KLAUS MAYER, M.D., F.A.C.P.Affiliations: New York, New YorkFrom the Departments of Medicine, Memorial Hospital for Cancer and Allied Diseases and James Ewing Hospital, and the Division of Clinical Investigation, Sloan-Kettering Institute for Cancer Research, New York, N. Y.This study was supported in part by grants CA-03809-07 and CA-08748, National Cancer Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Allyn B. Ley, M.D., The New York Hospital-Cornell Medical Center, 525 E. 68th St., New York, N. Y. 10021. 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