Cytarabine-Induced Inflammation in the Seborrheic Keratoses of Leser-Trélat
Authors: Paul Kechijian, Neil S. Sadick, Joseph Mariglio, Philip Schulman
Journal: Annals of Internal Medicine (1979)

Brief Reports1 December 1979Cytarabine-Induced Inflammation in the Seborrheic Keratoses of Leser-TrélatPAUL KECHIJIAN, M.D., NEIL S. SADICK, M.D., JOSEPH MARIGLIO, M.D., PHILIP SCHULMAN, M.D.PAUL KECHIJIAN, M.D.Search for more papers by this author, NEIL S. SADICK, M.D.Search for more papers by this author, JOSEPH MARIGLIO, M.D.Search for more papers by this author, PHILIP SCHULMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-6-868 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe sign of Leser-Trélat is constituted by a rapid increase in the size and number of seborrheic keratoses in patients with internal malignancies. Recently, a patient with acute myelogenous leukemia presented with this sign. Further, the patient's seborrheic keratoses became inflamed during two separate courses of therapy with cytarabine. In each instance, the inflammation rapidly subsided after cytarabine was discontinued. This report documents this response and comments on its significance.The patient, a 66-year-old housewife, enjoyed good health until the onset of easy fatigability, bruisability, and general malaise; simultaneously, she noted increased numbers of seborrheic keratoses. These symptoms, which persisted...References1. Kierland R. Cutaneous signs of internal malignancy. South Med J. 1972;65:563-8. CrossrefMedlineGoogle Scholar2. CURTH H. How and why the skin reacts. Ann NY Acad Sci. 1974;230:435-42. CrossrefMedlineGoogle Scholar3. DANTZIG P. Sign of Leser-Trélat. Arch Dermatol. 1973;108:700-1. CrossrefMedlineGoogle Scholar4. LIDDELL K, WHITE J, and CALDWELL I. Seborrheic keratoses and carcinoma of the large bowel. Br J Dermatol. 1975;92:449-52. CrossrefMedlineGoogle Scholar5. HARRINGTON C. Leser-Trélat sign with porphyria cutanea tarda and malignant hepatoma. Arch Dermatol. 1976;112:730. Letter. CrossrefMedlineGoogle Scholar6. DOLL D, MCCAGH M, and WELTON W. Sign of Leser-Trélat. JAMA. 1977;238:236-7. CrossrefMedlineGoogle Scholar7. SAFAI B, GRANT J, and GOOD R. Cutaneous manifestations of internal malignancies (II): the sign of Leser-Trélat. Int J Dermatol. 1978;17:494-5. CrossrefMedlineGoogle Scholar8. GREER K, HAWKINS H, and HESS C. Leser-Trélat associated with acute leukemia. Arch Dermatol. 1978;114:1552. Letter. CrossrefMedlineGoogle Scholar9. LEVINE N and GREENWALD E. Mucocutaneous side effects of cancer chemotherapy. Cancer Treat Rev. 1978;5:67-84. CrossrefMedlineGoogle Scholar10. BERMAN A and BERMAN J. Efflorescence of new warts: a sign of onset of involution in flat warts. Br J Dermatol. 1978;99:179-182. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL KECHIJIAN, M.D.; NEIL S. SADICK, M.D.; JOSEPH MARIGLIO, M.D.; PHILIP SCHULMAN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEruptive Seborrheic Keratoses Are Associated With a Co-Occurring Malignancy in the Majority of Reported Cases: A Systematic ReviewTargetoid erythema surrounding multiple seborrheic keratoses induced by chemotherapy with gemcitabineInflamação de queratoses seborreicas múltiplas induzida por quimioterapia com gencitabinaEffets cutanéo-muqueux indésirables des chimiothérapies antitumoralesEffets cutanés indésirables des chimiothérapies antitumorales et des cytokinesCutaneous Reactions to Chemotherapy and their ManagementParaneoplastic pityriasis lichenoides in cutaneous lymphoma: case report and review of the literature on paraneoplastic reactions of the skin in lymphoma and leukaemiaEfectos cutáneos adversos de la quimioterapia antineoplásica y de las citocinasChemotherapy-induced inflammation in seborrheic keratoses mimicking disseminated herpes zosterMucocutaneous reactions to chemotherapyCytosine Arabinoside-Induced VasculitisSign of Leser-Tre´latLeser-Trélat Sign Associated with Sézary SyndromeMucocutaneous side effects of chemotherapyThe sign of Leser-Trélat: Does it exist?Linear seborrheic keratoses associated with underlying malignancyThe Sign of Leser-TrélatCutaneous Side Effects of Cancer ChemotherapyEruptive Lesions and MalignancyEruptive Lesions and MalignancyA CASE OF ADENOSQUAMOUS CARCINOMA OF GASTRO-ESOPHAGEAL JUNCTION WITH LESER-TR^|^Eacute;LAT SIGNNeutrophilic eccrine hidradenitis: A distinctive rash associated with cytarabine therapy and acute leukemiaTHE SIGN OF LESER-TRÉLATCentral nervous system toxicity of high-dose systemic cytosine arabinoside 1 December 1979Volume 91, Issue 6Page: 868-869KeywordsAcute myeloid leukemiaInflammation ePublished: 1 December 2008 Issue Published: 1 December 1979 PDF downloadLoading ...