tbuckley/cabot-search huggingface dataset:
INVESTIGATIONS ON SYPHILIS AS AFFECTING THE HEALTH OF THE COMMUNITY: A Summary of the Collective Examination of over 3,000 Cases by Clinical and Serological Methods
Authors: C. H. Browning
Journal: BMJ (1914)

ORAL 7Mlillk is an excellent item in the diet, btut it i.s not alws-ays easily ligested, and consequenitlv it slhould be we-ll (liluted; it slhould be boiled to get ri(d of tlho Bacilluts coli and otlher organisms.rlTlle following will serve an adtult in, tlle acute stage for twenty-four lhours: About 2 pints of miiillk, .2 or 3 pints of barley water, wh11ey, or plaini water, 6 or .8oz. of syrLup of glucose, 4 or 5 draclhimis of table salt, anid 1 draclhm of the glyceroplhosplhate of calciumill.If the syrup of gluicose be too swveet or imlawklisl, a iarter of a pound of sugar of mill can-be used.Later on Llie patient can have peptoiiized bread and milk or solmie inifants' food, broths, rav eggs, jellies, cocoa or coffee, and a few bisouits.He cani lhave cold water, wlhen lhe likes; votu can wait on thle desire o$ tlle patient for solid food.Be always careftul that the bowels are not loaded or distended.In conclusion, I wislh strongly to impress on you.that pneumonia slhould always be looked upon as a serious disease; remember that nlo matter hlow mild tlle case may at first appear, you caninot always foirecast lhow it ilmay develop, and every miiedical maln, in dealing witlh tllis affection, slhould feel tlle responsibility of a lu3man life in lii.lhands.It lhas been said that yqung ilmen kill tlleir patients anid old iiien allo-wv-.them to die.I wishi you..totake a different course and direc thlien into a lharbour, of safety.Early recognition and prompt treatment will save maDy a valuable life.
Early fundholders quit after cash crisis
Authors: A. Boulton
Journal: BMJ (1996)

One of the first general practices to join the government's fundholding scheme is to be the first to leave. The practice in Plympton, Devon, joined the scheme five years ago. All eight principals at the practice, which has 15000 patients, took a joint decision to leave in March 1996 after it became clear that recent government changes to the scheme had resulted in a cash crisis.

The practice claims that the government's actions mean that patient care would subsequently suffer. “We joined the scheme believing that it was in our patients' …
SPECIFIC TREATMENT OF HAY-FEVER DURING THE ATTACK
Authors: WARREN T. VAUGHAN
Journal: JAMA (1923)

The present treatment of autumnal hay-fever consists in graded prophylactic inoculations of that pollen extract to which the patient is most sensitive, at weekly or more frequent intervals, from the latter part of May until the onset of the pollen season. The inoculations are then discontinued. In a certain percentage of patients so treated, there ensues either complete freedom from hay-fever or great amelioration of symptoms. A not inconsiderable proportion, however, experience little or no improvement, and a few apparently develop more severe attacks than in the years in which they received no prophylactic treatment.  In those cases showing little or no improvement, Walker 1 states that pollen extract injections may be continued, but in smaller amounts, given at the same intervals (from five to seven days). He finds that in some cases the symptoms are made worse by the injection of pollen extract during the hay-fever season.  MacKenzie 2
Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation
Authors: Robert R. Jenq, Christopher G. King, Christine Volk, David Suh, Odette M. Smith, Uttam K. Rao, Nury L. Yim, Amanda M. Holland, Sydney X. Lu, Johannes L. Zakrzewski, Gabrielle L. Goldberg, Adi Diab, Onder Alpdogan, Olaf Penack, Il-Kang Na, Lucy W. Kappel, Jedd D. Wolchok, Alan N. Houghton, Miguel-Angel Perales, Marcel R. M. van den Brink
Journal: Blood (2008)
Medical and Psychosocial Factors in Enuretic Children Treated with Imipramine Hydrochloride
Authors: PAUL M. BINDELGLAS, GEORGE H. DEE, FRANCIS A. ENOS
Journal: American Journal of Psychiatry (1968)

One hundred enuretic children participated in a long-term evaluation of imipramine hydrochloride as a treatment for enuresis. In addition, 20 of these children and their parents were chosen for an intensive social-medical and psychological evaluation. The authors conclude that imipramine hydrochloride is safe and effective in the treatment of enuresis, although beneficial results are not usually dramatic and may occur only after a long period of time. A significant pattern of family interaction and a possible hereditary factor were observed within the families who were intensively studied.
PREDICTORS OF PCI IN PATIENTS UNDERGOING ELECTIVE CARDIAC CATHETERIZATION FOR CHRONIC ISCHEMIC HEART DISEASE
Authors: Auras R. Atreya, Senthil K. Sivalingam, Sonali Arora, Mohammad Amin Kashef, Paul Visintainer, Amir Lotfi, Michael B. Rothberg
Journal: Journal of the American College of Cardiology (2013)
Effect of Age and Diagnosis on Survival of Older Patients Beginning Chronic Dialysis
Authors: Colene Byrne
Journal: JAMA (1994)

<h3>Objective.</h3> —To assess the survival of elderly patients in the United States beginning chronic dialysis for end-stage renal disease caused by diabetes mellitus, hypertension, glomerulonephritis, polycystic kidney disease, and other causes. <h3>Design.</h3> —A secondary analysis of data obtained from the Health Care Financing Administration. <h3>Patients.</h3> —All Medicare end-stage renal disease patients 55 years of age or older (n=95 394) who began chronic dialysis treatment in the US between 1982 and 1987. <h3>Main Outcome Measures.</h3> —The 1-, 3-, and 5-year survival rates for each of six age strata and, within each strata, for each of the four most frequent causes of renal failure. <h3>Results.</h3> —Survival rates of dialysis patients fell precipitously, and much more rapidly for the study group than for the general population, as a function of advancing age. Older patients with diabetic nephropathy fared particularly badly, such that no patients with diabetic nephropathy aged 85 years or more survived 5 years. <h3>Conclusions.</h3> —Mortality rates of patients older than 55 years beginning chronic dialysis treatment increased dramatically as age at initiation of dialysis increased. Clinically meaningful survival data should prove useful to persons making decisions about the initiation of chronic dialysis. (<i>JAMA</i>. 1994;271:34-36)
219 THE RELATIONSHIP BETWEEN SEXUAL DYSFUNCTION (SD) AND QUALITY OF LIFE (QOL) IN MALE AFTER LIVER TRANSPLANTATION
Authors: A. Masier, A. Salonia, G. Germani, M. Gambato, E. De Martin, M. Senzolo, F.P. Russo, P. Boccagni, U. Cillo, G.C. Sturniolo, P. Burra
Journal: Journal of Hepatology (2008)
Enacting emotional interpretations with feeling
Authors: Giovanna Colombetti, Evan Thompson
Journal: Behavioral and Brain Sciences (2005)

This commentary makes three points: (1) There may be no clear-cut distinction between emotion and appraisal “constituents” at neural and psychological levels. (2) The microdevelopment of an emotional interpretation contains a complex microdevelopment of affect. (3) Neurophenomenology is a promising research program for testing Lewis's hypotheses about the neurodynamics of emotion-appraisal amalgams.
The Role of Gastrointestinal Endoscopy in a Developing Country
Authors: B. Al Nakib, S. Radhakrishnan, H. Al Liddawi, G.S. Jacob, A. Al Ruwaih
Journal: Endoscopy (1986)

Eight-thousand-six-hundred-and-eighty patients were examined endoscopically over a period of six years. Significant pathological lesions were detected in 79.6% of the cases. While duodenal ulcers were seen at the same frequency as in the West, the number of gastric ulcers were considerably fewer, the ratio of gastric to duodenal ulcer being 1:8.4. Gastric cancer was also observed less commonly than in the West, but gastric lymphoma constituted 21% of all gastric malignancies. By endoscoping all bleeders within 24 hours we were able to identify the source of bleeding in 90.9% of the cases, and a lesion was detected in 96.8%. Direct visualisation of the duodenal and jejunal mucosa supported by histological examination was of paramount importance in the early detection of Immunoproliferative Small Intestinal Disease (IPSID) and its differentiation from other diseases such as tuberculosis, bilharzial jejunitis and Crohn's disease which are seen in our population.
Spacer devices in the treatment of asthma
Authors: C. O'Callaghan, P. Barry
Journal: BMJ (1997)

hould the BMJ reject all studies that do not include informed consent?That's a simple question, and surely the answer should be equally simple-"Yes."Unfortunately, ethical questions rarely allow simple answers, and we want help with answering this one.This issue includes a cluster of material that relates to the question.We publish the materialincluding two studies in which informed consent was not sought-to encourage debate and to arrive at a deeper understanding if not a simple answer.Medical journals must consider the ethical aspects of all the material they publish, and medical editors are presented with ethical issues just as often as doctors-that is, every day.
Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α
Authors: Woo-Young Kim, Seung Hyun Oh, Jong-Kyu Woo, Waun Ki Hong, Ho-Young Lee
Journal: Cancer Research (2009)

Hypoxia-inducible factor-1 (HIF-1) has been suggested to play a major role in tumor radioresistance. However, the mechanisms through which irradiation regulates HIF-1alpha expression remain unclear. The purpose of this study was to investigate the mechanisms that mediate HIF-1 activation and thus radioresistance. Here, we show that irradiation induces survival and angiogenic activity in a subset of radioresistant lung cancer cell lines by elevating HIF-1alpha protein expression. Radiation induced HIF-1alpha protein expression mainly through two distinct pathways, including an increase in de novo protein synthesis via activation of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and stabilization of HIF-1alpha protein via augmenting the interaction between heat shock protein 90 (Hsp90) and HIF-1alpha protein. Whereas the PI3K/Akt/mTOR pathway was activated by irradiation in all the lung cancer cells examined, the Hsp90-HIF-1alpha interaction was enhanced in the resistant cells only. Inhibition of Hsp90 function by 17-allylamino-17-demethoxygeldanamycin or deguelin, a novel natural inhibitor of Hsp90, suppressed increases in HIF-1alpha/Hsp90 interaction and HIF-1alpha expression in radioresistant cells. Furthermore, combined treatment of radiation with deguelin significantly decreased the survival and angiogenic potential of radioresistant lung cancer cells in vitro. We finally determined in vivo that systemic administration of deguelin resulted in profound inhibition of tumor growth and angiogenesis when combined with radiation. These results provide a strong rationale to target Hsp90 as a means to block radiation-induced HIF-1alpha and thus to circumvent radioresistance in lung cancer cells.
Pain and Discomfort Associated With Film-Screen Mammography
Authors: B. B. Nielsen, C. Miaskowski, S. L. Dibble, B. Beber, N. Altman, C. B. McCoy
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Pain and Discomfort Associated With Film-Screen Mammography Get access Beverly B. Nielsen, Beverly B. Nielsen * 1School of Nursing and Sylvester Comprehensive Cancer Center, University of MiamiMiami, Fla *Correspondence to: Beverly B. Nielsen, R.N., Ed.D., P.O.Box 016960 (D-72), Sylvester Comprehensive Cancer Center, Miami, FL 33101 Search for other works by this author on: Oxford Academic PubMed Google Scholar Christine Miaskowski, Christine Miaskowski 2Department of Physiological Nursing, University of CaliforniaSan Francisco Search for other works by this author on: Oxford Academic PubMed Google Scholar Suzanne L. Dibble, Suzanne L. Dibble 2Department of Physiological Nursing, University of CaliforniaSan Francisco Search for other works by this author on: Oxford Academic PubMed Google Scholar Bernard Beber, Bernard Beber 3Department of Radiology and Sylvester Comprehensive Cancer Center, University of Miami Search for other works by this author on: Oxford Academic PubMed Google Scholar Norman Altman, Norman Altman 4Sylvester Comprehensive Cancer Center, University of Miami Search for other works by this author on: Oxford Academic PubMed Google Scholar Clyde B. McCoy Clyde B. McCoy 4Sylvester Comprehensive Cancer Center, University of Miami Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 23, 4 December 1991, Pages 1754–1756, https://doi.org/10.1093/jnci/83.23.1754 Published: 04 December 1991 Article history Received: 09 April 1991 Revision received: 26 August 1991 Accepted: 10 September 1991 Published: 04 December 1991
A METHOD OF TREATING FRACTURES OF THE SUPERIOR MAXILLA.
Authors: RAYMOND RUSS
Journal: JAMA (1905)

Although the body of the superior maxilla is not frequently broken, the surgeon occasionally finds fractures of the processes as the result of direct violence. The alveolar arch may be broken by a heavy fist blow, and the deformity which results is many times considerable and difficult to maintain in proper reduction. The ingenuity of the operator who treats these conditions in emergency practice is often taxed to the utmost. While it may be necessary for him at times to call a skilled dentist to his assistance, still it will be possible for him to treat nearly all these fractures single handed. I have previously laid stress on the fact that the oral functions should be maintained in fractures of the jaws. To reduce properly and to immobilize the fragments, to retain the power of speech and the ability to take food, and to avoid the dangers of sepsis by
Prevention of Melanoma With Regular Sunscreen Use
Authors: June K. Robinson, Michael Bigby
Journal: JAMA (2011)

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Entecavir treatment in patients with severe acute exacerbation of chronic hepatitis B
Authors: Vincent Wai-Sun Wong, Grace Lai-Hung Wong, Karen Kar-Lum Yiu, Angel Mei-Ling Chim, Shirley Ho-Ting Chu, Hoi-Yun Chan, Joseph Jao-Yiu Sung, Henry Lik-Yuen Chan
Journal: Journal of Hepatology (2010)
HEPATIC DYSFUNCTION IN DOGS FED DIETS CAUSATIVE OF BLACK TONGUE
Authors: C. P. Rhoads, D. K. Miller
Journal: The Journal of Experimental Medicine (1938)

1. The feeding to dogs of a diet lacking the vitamin B(2) (G) complex results in a lowered capacity of the liver to excrete intravenously injected bilirubin. 2. Normal function can be partly restored by supplementing the diet with liver extract. 3. Normal function can be completely restored by feeding a normal diet.
Papanicolaou Smear Testing in Elderly Women-Reply
Authors: Irene Gopaul
Journal: JAMA (1986)

<h3>In Reply.—</h3> Drs Kochersberger and Studenski raise important issues to be considered in designing strategies for screening and disease prevention in the elderly. We are completing a cost-effectiveness analysis of our cervical cancer screening program to address these questions. The analysis tests the effects of varying the uncertain parameters of the natural history of cervical cancer, Papanicolaou smear testing, and quality of life on the cost-effectiveness of the program. There is little information in the literature on cervical carcinoma that is specifically applicable to elderly women. Data do suggest that cervical cancer behaves in a more biologically aggressive manner in older women. The transition time between stages of cervical abnormalities has been observed to elapse four times more rapidly in elderly women compared with younger women.<sup>1</sup>Epidemiologic observations consistent with rapid disease progression in the elderly yield estimates of between three to nine years for progression from normal cervical
Accreditation: Protecting the Professional or the Consumer?
Authors: R. Robinson
Journal: BMJ (1995)

Ellie Scrivens Open University Press, £12.99, pp 184 ISBN 0335194915

Accreditation, in the sense that it is used in Ellie Scrivens's book, is a system of non-governmental self regulation in which an independent agency defines and monitors standards of quality in hospitals and other health service providers participating in the scheme. Its origins date from 1917 when it was first developed in the United States on the initiative of the medical profession. Since then models building on the American approach have been developed in Canada and Australia.

In Britain the development of accreditation has been …
Induction of IgE antibodies in mice and rhesus monkeys with recombinant birch pollen allergens: Different allergenicity of Bet v 1 and Bet v 2
Authors: Susanne Vrtala, Peter Mayer, Fatima Ferreira, Markus Susani, Alec H. Sehon, Dietrich Kraft, Rudolf Valenta
Journal: Journal of Allergy and Clinical Immunology (1996)
Vaginal delivery after caesarean section triples risk of uterine rupture
Authors: D. Josefson
Journal: BMJ (2001)

Women who have a vaginal delivery after a caesarean section face three times the risk of uterine rupture than those who have a second caesarean section, a new report has said ( New England Journal of Medicine 2001;345:3-8).

The study bolsters the old adage, “Once a caesarean section, always a caesarean section.” Moreover, the risk of rupture was five times greater …
The impact of the spending review on health and social care
Authors: D. J. Hunter
Journal: BMJ (2010)

A combination of spending cuts and NHS restructuring do not bode well for the future

The coalition government has finally wielded its long threatened axe with results that do not bode well for the NHS and social care.1 Spending on the NHS is to be slashed from an annual increase of 6% to 0.4% over the next four years, starting in April. Excluding the £15bn (€16.8bn; $23.6bn) to £20bn savings target, and with the promised modest increase amounting in practice to a cut in purchasing power once pay and other increases have been factored in, the key question is now whether what was announced by the chancellor will actually be implemented. By cutting public spending so far and so fast, the entire economic recovery may be at risk⇓.2



If a week is a long time in politics then four years is an eternity, and a great deal may (and can) yet happen to modify, or even derail, the government’s various plans for spending cuts and restructuring. At the same time, strategic health authorities, primary care trusts, and local authorities are rushing to make deep cuts, often ahead of the need to do so, which means that many of the half million public …
HERPES GESTATIONIS INFLUENCED BY AN ORAL CONTRACEPTIVE
Authors: JOHN K. MORGAN
Journal: British Journal of Dermatology (1968)

Journal Article HERPES GESTATIONIS INFLUENCED BY AN ORAL CONTRACEPTIVE Get access JOHN K. MORGAN JOHN K. MORGAN Department of Dermatology, South Tees‐side Hospital Group Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 7, 1 July 1968, Pages 456–458, https://doi.org/10.1111/j.1365-2133.1968.tb11981.x Published: 01 July 1968 Article history Accepted: 01 April 1968 Published: 01 July 1968
Evaluation of Treatment in Intermittent Claudication
Authors: J. T. Shepherd
Journal: BMJ (1950)

therefore plasma H2C03.The clinical counterpart of this physiological adjustment is the slow deep breathing on salicylate administration.It is realized that a single case has been cited as evidence of a possible common action of aspirin and cortisone, but on examination of our records of previous cases of acute rheumatism treated with sodium salicylate we find that frequent reference is made to puffiness of the face and acne-like lesions on the face, front of chest, and back.In fact, puffiness of the face may be observed in almost every patient receiving full therapeutic doses of salicylate, and it tends to be most pronounced in children.Most of these patients also had a reducing substance in the urine which was assumed to be a salicylate fallacy.However, addition of salicylic acid, sodium salicylate, and aspirin to normal urine in concentrations greater than we have ever encountered in the urine of patients under treatment failed to show any reduction of Benedict's solution.This does not exclude the presence of reducing substances other than glucose, but it may well be that the reductions pre- viously observed were partly if not wholly due to glucose.These retrospective observations suggest that the development of mild Cushing's syndrome during intensive sali- cylate treatment is not uncommon, but there are many points requiring further investigation before any final con- clusion may be drawn.Nevertheless, it is thought that this initial report is justified in view of the significance of the findings.SummaryThe clinical and metabolic effects of aspirin in the treat- ment of acute rheumatism resemnble closely those attributed to cortisone.A case is presented, and others referred to, in which the similarity in action of the two substances is further strengthened by the development under aspirin treatment of side-effects suggesting a mild Cushing's syndrome.The effects observed were rounding of the facial contours, acne, diminished glucose tolerance, glycosuria, and alteration of the mental state.Some important considerations arising out of this conception are discussed.We thank Professor J. W. McNee for his advice and generous help in providing
Facilitation of μ-Opioid Receptor Activity by Preventing δ-Opioid Receptor-Mediated Codegradation
Authors: Shao-Qiu He, Zhen-Ning Zhang, Ji-Song Guan, Hong-Rui Liu, Bo Zhao, Hai-Bo Wang, Qian Li, Hong Yang, Jie Luo, Zi-Yan Li, Qiong Wang, Ying-Jin Lu, Lan Bao, Xu Zhang
Journal: Neuron (2011)