Conjugal Graves Disease
Authors: Susana A. Ebner, Marie-Claude Badonnel, Lawrence K. Altman, Lewis E. Braverman
Journal: Annals of Internal Medicine (1992)

Brief Reports15 March 1992Conjugal Graves DiseaseSusana A. Ebner, MD, Marie-Claude Badonnel, PhD, Lawrence K. Altman, MD, Lewis E. Braverman, MDSusana A. Ebner, MDSearch for more papers by this author, Marie-Claude Badonnel, PhDSearch for more papers by this author, Lawrence K. Altman, MDSearch for more papers by this author, Lewis E. Braverman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-6-479 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyperthyroid Graves disease is an autoimmune disorder characterized by thyrotoxicosis, diffuse goiter, and antibodies directed against the thyrotropin (TSH) receptor, thyroglobulin (Tg), and thyroid peroxidase (TPO). The TSH receptor antibody is believed to stimulate the generation of cAMP in the thyroid, resulting in the increased synthesis and release of the thyroid hormones. The abnormal function of the immune system found in patients with this disease is strongly linked to a genetic predisposition. The incidence of thyroid disease among monozygotic twins is approximately 50%. This lack of complete concordance suggests that environmental factors, including infectious agents such asYersinia enterocolitica(1)...References1. ShenkmanBottone LE. Antibodies to Yersinia enterocolitica in thyroid disease. Ann Intern Med. 1976;85:735-9. LinkGoogle Scholar2. CiampolilloMariniMirakianBuscemaSchulzPujol-Borrell AVRMTR. Retrovirus-like sequences in Graves' disease: implications for human autoimmunity. Lancet. 1989;1:1096-100. CrossrefMedlineGoogle Scholar3. BrownlieHedleyBremner BJJ. Conjugal thyroid disease—six couples with thyrotoxicosis, one couple with hypothyroidism, and one couple with thyroid cancer. N Z Med J. 1980;91:246-8. MedlineGoogle Scholar4. Fernandez CastanerAngel PotauCabrer ReusErcilla MMJM. HLA antigens in a family with both parents and several siblings affected by Graves' disease. Acta Endocrinol. 1983;102:535-8. CrossrefMedlineGoogle Scholar5. Hoffenberg R. Aetiology of hyperthyroidism. I. Br Med J. 1974;3:452-5. CrossrefMedlineGoogle Scholar6. TunbridgeEveredHallAppletonBrewisClark WDRDMF. The spectrum of thyroid disease in a community: The Whickham survey. Clin Endocrinol. 1977;7:481-93. CrossrefMedlineGoogle Scholar7. WeissIngbarWinbladKasper MSSD. Demonstration of a saturable binding site for thyrotropin in Yersinia enterocolitica. Science. 1983;219:1331-3. CrossrefMedlineGoogle Scholar8. HumphreyMoscaBakerDrabickCarrBurke MJJJFD. Absence of retroviral sequences in Graves' disease. Lancet. 1991;337:17-8. CrossrefMedlineGoogle Scholar9. GaitanCookseyLeganMontalvoPino ERJJJ. Simple goiter and autoimmune thyroiditis: Environmental and genetic factors. Clinical Ecology. 1985;3:158-61. Google Scholar10. VagenakisWangBurgerMaloofBravermanIngbar ACAFLS. Iodide induced thyrotoxicosis in Boston. N Engl J Med. 1972;287:523-7. CrossrefMedlineGoogle Scholar11. WinsaAdamiBergströmGamstedtDahlbergAdamson BHRAPU. Stressful life events and Graves' disease. Lancet. 1991;338:1475-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Susana A. Ebner, MD; Marie-Claude Badonnel, PhD; Lawrence K. Altman, MD; Lewis E. Braverman, MDAffiliations: From the University of Massachusetts Medical Center, Worcester, Massachusetts. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGraves Disease and Gynecomastia in 2 RoommatesAn Interview with Lewis E. Braverman M.D.Infection and Endocrine Autoimmunity 15 March 1992Volume 116, Issue 6Page: 479-481KeywordsAntibodiesEndocrinologyGenetic predispositionPeroxidasesRenal diseasesThyroglobulinThyroidThyroid diseasesThyroid hormonesThyroid-stimulating hormone ePublished: 1 December 2008 Issue Published: 15 March 1992 PDF downloadLoading ...