Evidence of Hepatitis C Virus Viremia without Detectable Antibody to Hepatitis C Virus in a Blood Donor
Authors: Françoise Durand, Alain Beauplet, Patrick Marcellin
Journal: Annals of Internal Medicine (2000)

Letters4 July 2000Evidence of Hepatitis C Virus Viremia without Detectable Antibody to Hepatitis C Virus in a Blood DonorFrançoise Durand, MD, Alain Beauplet, MD, PhD, and Patrick Marcellin, MD, PhDFrançoise Durand, MDEtablissement Français du Sang-Bretagne; 35000 Rennes, France (Durand)Etablissement Français du Sang-Bretagne; 35000 Rennes, France (Beauplet)Hôpital Beaujon; 92110 Clichy, France (Marcellin)Search for more papers by this author, Alain Beauplet, MD, PhDEtablissement Français du Sang-Bretagne; 35000 Rennes, France (Durand)Etablissement Français du Sang-Bretagne; 35000 Rennes, France (Beauplet)Hôpital Beaujon; 92110 Clichy, France (Marcellin)Search for more papers by this author, and Patrick Marcellin, MD, PhDEtablissement Français du Sang-Bretagne; 35000 Rennes, France (Durand)Etablissement Français du Sang-Bretagne; 35000 Rennes, France (Beauplet)Hôpital Beaujon; 92110 Clichy, France (Marcellin)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-1-200007040-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In July 1999, the European Agency for Evaluation of Drugs recommended screening of plasma for hepatitis C virus (HCV) RNA by polymerase chain reaction (PCR). The Laboratoire Français du Fractionnement et des Biotechnologies started screening in January 1998. Of 2 million plasma units tested, 4 were positive. Three were obtained from donors who seroconverted for anti-HCV within 3 months, and 1 was obtained from a regular donor who remained seronegative for anti-HCV (18 months of follow-up).The latter donor is a 46-year-old woman who gave blood regularly (28 times from 1988 to 1997). She never received blood ...Reference1. Esteban JL, Gomez J, Martell M, Cabot B, Quer J, Camps J, et al . Transmission of hepatitis C virus by a cardiac surgeon. N Engl J Med. 1996;334:555-60. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Françoise Durand, MD; Alain Beauplet, MD, PhD; Patrick Marcellin, MD, PhDAffiliations: Etablissement Français du Sang-Bretagne; 35000 Rennes, France (Durand)Etablissement Français du Sang-Bretagne; 35000 Rennes, France (Beauplet)Hôpital Beaujon; 92110 Clichy, France (Marcellin) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEstablishment of a keratinocyte and fibroblast bank for clinical applications in JapanDescription of 15 DNA-positive and antibody-negative “window-period” blood donations identified during prospective screening for Babesia microtiOccult infection with hepatitis C virus: friend or foe?Seronegative Hepatitis C Virus Infection in a Child Infected via Mother-to-Child TransmissionInvestigation of post-transfusion infectionHow to assess risk: prospective studies and calculationsHigh levels of subgenomic HCV plasma RNA in immunosilent infectionsAntibodies to a novel antigen in acute hepatitis C virus infectionsProtective immunity against hepatitis C virus infectionRisk factors for HCV infection among blood donors confirmed to be positive for the presence of HCV RNA and not reactive for the presence of anti-HCVHCV viral load in anti-HCV-reactive donors and infectivity for their recipientsFollow-up of six blood donors highlights the complementary role and limitations of hepatitis C virus antibody and nucleic acid amplification testsA new HCV core antigen assay based on disassociation of immune complexes: an alternative to molecular biology in the diagnosis of early HCV infectionNucleic acid technology screening of Australian blood donors for hepatitis C and human immunodeficiency virus-1 RNA: comparison of two high-throughput testing strategiesHepatitis C Virus Viremia in HIV-Infected Individuals With Negative HCV Antibody TestsTrends in residual risk of transfusion-transmitted viral infections in France between 1992 and 2000The first case of HCV seroconversion in Portugal after the introduction of HCV NAT screeningEffect of Coexisting HIV-1 Infection on the Diagnosis and Evaluation of Hepatitis C VirusEffect of Coexisting HIV-1 Infection on the Diagnosis and Evaluation of Hepatitis C VirusBlood donors infected with the hepatitis B virus but persistently lacking antibodies to the hepatitis B core antigenProlonged antibody-negative HCV viremia in a US blood donor with apparent HCV transmission to a recipient 4 July 2000Volume 133, Issue 1Page: 74-75KeywordsBloodBlood banksBlood donorsBlood plasmaDrugsHepatitis C virusLymphocytesRNASerum albuminViremia ePublished: 15 August 2000 Issue Published: 4 July 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...