tbuckley/cabot-search huggingface dataset:
Echocardiographic Evaluation of Hemodynamics in Patients With Systolic Heart Failure Supported by a Continuous-Flow LVAD
Authors: Jerry D. Estep, Rey P. Vivo, Selim R. Krim, Andrea M. Cordero-Reyes, Barbara Elias, Matthias Loebe, Brian A. Bruckner, Arvind Bhimaraj, Barry H. Trachtenberg, Guha Ashrith, Guillermo Torre-Amione, Sherif F. Nagueh
Journal: Journal of the American College of Cardiology (2014)
Development of a novel therapeutic approach using a retinoic acid-loaded microneedle patch for seborrheic keratosis treatment and safety study in humans
Authors: Yasuhiro Hiraishi, Sachiko Hirobe, Hiroshi Iioka, Ying-Shu Quan, Fumio Kamiyama, Hideo Asada, Naoki Okada, Shinsaku Nakagawa
Journal: Journal of Controlled Release (2013)
939-81 Thrombolysis Enhanced by Ultrasound on Intracoronary Thrombus
Authors: Hirohito Sekiguchi, Kenji Hamano, Sunao Yoshizawa, Makoto Muto, Toshihiko Urushibara, Kotaro Kifune, Sumihiko Kudo, Masatada Hara, Hiroshi Furuhata, Tetsuo Okamura
Journal: Journal of the American College of Cardiology (1995)
Abstract 4608: Hydrogen sulfide-releasing aspirin inhibits the growth of leukemic Jurkat cells and modulates β-catenin expression
Authors: Zong Yuan Gan, Mitali Chattopadhyay, Ravinder Kodela, Daniel Boring, James A. Crowell, Khosrow Kashfi
Journal: Cancer Research (2011)

Abstract Introduction: Acute leukemia is the primary cause of cancer-related mortality in children. ß -catenin, a regulator of cell-cell adhesion and transcription, is expressed in T-acute lymphoblastic leukemia cells, tumor lines of hematopoietic origin and primary leukemia cells but not in normal peripheral blood T cells. ß -catenin may promote leukemia cell proliferation, adhesion, and survival. Hydrogen sulfide-releasing aspirin (HS-ASA) is a novel compound with significant potential for the control of cancer. It consists of a traditional ASA molecule covalently bound to an H2S-releasing moiety (5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione). Here we examined the effect of HS-ASA on the growth of Jurkat T-acute lymphoblastic leukemia cells and on the fate of ß -catenin. Methods: HS-ASA was synthesized and purified at our lab with 1H-NMR verification. Cell line: Jurkat T-leukemia. Quantification of cell growth: MTT assay. Cell kinetics: cell cycle phase distribution by flow cytometry; apoptosis by subdiploid (sub-G0/G1) peak in DNA content histograms; and proliferation by PCNA. ß-Catenin and caspase-3 expression was assayed by immunoblotting in cells treated with HS-ASA at 24 hr. Caspase-3 enzyme activity, and H2S levels was also measured. Results: 1) The IC50 for HS-ASA was 1.5 ± 0.2 µM, whereas that of ASA was &amp;gt;5000 µM strongly suggesting that HS-ASA is at least 3000-fold more potent than traditional ASA. 2) At 0.5xIC50, 1xIC50, and 2xIC50 the following observations were made: Proliferation was inhibited by 88 ± 2%, 63 ± 2%, 42 ± 3%; apoptosis was increased by 15 ± 2%, 39 ± 3%, 54 ± 4%; and cells in the G0/G1 phase increased dose-dependently whereas those in the S and G2/M phases decreased, suggesting a G0/G1 block. 3) HS-ASA dose-dependently reduced the levels of ß-catenin, whereas ASA up to 5 mM had no effect on ß-catenin expression. HS-ASA also increased caspase-3 protein levels and increased its activity dose-dependently, at 0 (no treatment), 0.5xIC50, 1xIC50, and 2xIC50 the values were 3.9 ± 0.3, 12.3 ± 0.5, 23.3 ± 0.7, and 42.6 ± 1.2 pmol/min/mg protein. H2S levels also increased as a function of HS-ASA concentration. Conclusion: HS-ASA strongly inhibits the growth of Jurkat T cells and causes inhibition of ß-catenin expression. These studies suggest one mechanism by which HS-ASA inhibits the growth of Jurkat T cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4608. doi:10.1158/1538-7445.AM2011-4608
Mechanism of Protein Kinase B Activation by Insulin/Insulin-Like Growth Factor-1 Revealed by Specific Inhibitors of Phosphoinositide 3-Kinase—Significance for Diabetes and Cancer
Authors: Ivana Galetic., Mirjana Andjelkovic., Roger Meier, Daniela Brodbeck, Jongsun Park, Brian A. Hemmings
Journal: Pharmacology & Therapeutics (1999)
What's Best in the Treatment of Stress Urinary Incontinence?
Authors: Rebecca G. Rogers
Journal: New England Journal of Medicine (2010)

A participant in a recent postgraduate course on urinary incontinence said to a panel of surgical experts: "Just tell us what surgery works well, without complications, so that we can take better care of our patients." Like most surgeons, the course participant was searching for the best operation for incontinence, one that had perfect success rates without complications. The panel made a complicated response to this simple request. Choosing the "best" surgery for stress urinary incontinence requires consideration of the goals, the needs, and the health of the patient, as well as the skill and training of the surgeon performing . . .
Long-Term Outcome of Complete Cytogenetic Responders After Imatinib 400 mg in Late Chronic Phase, Philadelphia-Positive Chronic Myeloid Leukemia: The GIMEMA Working Party on CML
Authors: Francesca Palandri, Ilaria Iacobucci, Giovanni Martinelli, Marilina Amabile, Angela Poerio, Nicoletta Testoni, Simona Soverini, Fausto Castagnetti, Antonio De Vivo, Massimo Breccia, Giorgina Specchia, Elisabetta Abruzzese, Bruno Martino, Daniela Cilloni, Giuseppe Saglio, Fabrizio Pane, Anna Marina Liberati, Gianantonio Rosti, Michele Baccarani
Journal: Journal of Clinical Oncology (2007)

Purpose Imatinib mesylate (IM) has rapidly become the front-line treatment of Philadelphia-positive (Ph-pos) chronic myeloid leukemia, but the number of patients who were treated and are being treated with IM second-line is still substantial. Patients and Methods We have monitored and analyzed the cytogenetic and molecular response to IM 400 mg/d in a cohort of 277 late chronic phase (LCP) patients who were resistant or intolerant to interferon-α and were observed for 48 to 79 months (median, 72 months). Results One hundred fifty-three patients (55%) achieved a complete cytogenetic response (CCgR). Seventy-seven percent of them were still in CCgR after 5 years. The rate of response loss did not increase over time. The 6-year progression-free survival and overall survival of these 153 complete cytogenetic responders were 90% and 91%, respectively. Molecular response was less than major in 21%, major in 78%, and complete in one patient only. Conclusion These data confirm that, in LCP the CCgR rate to IM is 50% to 60%, and show that CCgR is stable and is associated with a prolonged survival, even if leukemia continues to be molecularly detectable.
Lowering of fasting and food stimulated serum immunoreactive gastric inhibitory polypeptide (GIP) by glucagon.
Authors: R Ebert, R Arnold, W Creutzfeldt
Journal: Gut (1977)

The effect of intravenous glucagon infusion on serum levels of immunoreactive GIP (IR-GIP), insulin (IRI), gastrin (IRG), and on blood glucose has been investigated in six healthy volunteers in the fasting state and during ingestion of a mixed standard meal. Glucagon (500 ng/kg/min) lowered significantly serum levels of IR-GIP and IRG below the fasting values and increased the levels of IRI and blood glucose. Glucagon (50 ng/kg/min) infused 30 minutes before and continued 90 minutes after ingestion of a test meal abolished the IR-GIP response, suppressed significantly the IRG response, and left the IRI response unchanged. The same glucagon dose infused 60 minutes after ingestion of the test meal decreased significantly the raised levels of IR-GIP and IRG to fasting levels without changing IRI values. It is concluded that exogenous glucagon inhibits Gip release at the level of the GIP-producing cells.
Female-to-Male Transmission of HIV-Reply
Authors: Nancy S. Padian
Journal: JAMA (1992)

In Reply.  —Population-based generalizations from partner studies often are inappropriate. Partner studies evaluate the risk of transmission due to exposure rather than likelihood of exposure, so they cannot estimate frequency of transmission in populations as Drs Haverkos and Battjes implicitly propose. Likewise, because the distribution of known and unknown cofactors varies across study samples, one would expect heterogeneous transmission rates.  Another difference among studies could stem from how effectively the mode of transmission is ascertained. Although in their study De Vincenzi and Ancelle-Park report no differences in transmission rates according to the risk group of the index case, 1 68% of the female-to-male cases observed occurred among the partners of intravenous drug users (IVDU). It is often difficult to rule out drug use in sexual partners of IVDUs, making it problematic both to control for nonsexual exposures and to determine the true index case. Thirteen of the 14 concordant couples
Aromatase activity in the ovary and brain of the eastern mosquitofish (Gambusia holbrooki) exposed to paper mill effluent.
Authors: Edward F Orlando, William P Davis, Louis J Guillette
Journal: Environmental Health Perspectives (2002)

Studies have shown that female mosquitofish living downstream of a paper mill located on the Fenholloway River, Florida, have masculinized secondary sex characteristics, including altered anal fin development and reproductive behavior. Masculinization can be caused by exposure to androgens in the water or from an alteration in aromatase activity in the fish. We hypothesized that aromatase activity would be inhibited by a component(s) of the paper mill effluent. Aromatase inhibition could masculinize the hormonal profile and, subsequently, secondary sex characteristics of the exposed females. Therefore, we predicted that ovarian and brain aromatase activity would be lower in the female mosquitofish from the Fenholloway River compared with the reference site, the Econfina River. Adult females were collected and standard length, body mass, anal fin length, and segment number were measured. Ovarian and brain aromatase activity were determined using a tritiated water assay. Fenholloway females had masculinized anal fin development as indicated by an increase in the number of segments in the longest anal fin ray (p < 0.0001), yet the length of the ray did not differ between sites (p = 0.95). Fenholloway females exhibited higher ovarian (p = 0.0039) and brain (p = 0.0003) aromatase activity compared with reference site fish. These data do not support aromatase inhibition as the mechanism for masculinization, suggesting that the masculinization of the Fenholloway female mosquitofish is due to androgenic contaminants. Future studies should examine the relationship between aromatase enzyme activity and exposure to environmental androgens.
Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing‐Neel syndrome: Case report and review of the literature
Authors: Julio Delgado, Miguel Angel Canales, Beatriz Garcia, Javier Alvarez‐Ferreira, Antonio Garcia‐Grande, Fernando Hernandez‐Navarro
Journal: American Journal of Hematology (2002)

Abstract Waldenström's macroglobulinemia is a low‐grade lymphoma that produces monoclonal IgM. Central nervous system symptoms are frequent in Waldenström's macroglobulinemia, mostly associated with blood hyperviscosity. Nevertheless, central nervous system infiltration by malignant cells (Bing‐Neel syndrome) has rarely been reported. We describe the case of a 72‐year‐old man with Waldenstrom's macroglobulinemia and central nervous system infiltration by malignant cells with tumor formation. All similar cases reported in the literature are reviewed and the different therapeutic approaches discussed. Am. J. Hematol. 69:127–131, 2002. © 2002 Wiley‐Liss, Inc.
The future of purchasing
Authors: C Ham
Journal: BMJ (1994)

<h3>Abstract</h3> Infection with the mosquito-borne Chikungunya virus (CHIKV) causes acute or chronic arthritis in humans. Inflammatory responses mediated by monocytes, the primary target cells of CHIKV infection in the blood, are considered to play an important role in CHIKV pathogenesis. A recent study revealed that the acute phase of CHIKV infection is characterized by a monocyte-driven response, with an expansion of the intermediate monocyte (IM) subset. In this study, we adopted a previously established in vitro model of CHIKV infection in peripheral blood mononuclear cells, to elucidate the mechanism and relevance of IM expansion in CHIKV replication and associated inflammatory responses. Our data show that infectious but not replication-incompetent CHIKV increases the frequency of IM and to a lesser extent, non-classical (NM) monocytes while reducing the number of classical monocytes (CM). The increase of IM or NM frequency coincided with the activation of inflammatory response and occurred in the absence of lymphocytes implying that monocyte-derived cues are sufficient to drive this effect. Importantly, priming of monocytes with LPS prevented expansion of IM and NM but had no effect on viral replication. It did however alter CHIKV-induced cytokine signature. Taken together, our data delineate the role of IM in CHIKV infection-specific innate immune responses and provide insight for the development of therapeutic strategies that may focus on rewiring monocyte immune responses to prevent CHIKV-mediated arthralgia and arthritis.
Home Monitoring Service Improves Mean Arterial Pressure in Patients with Essential Hypertension
Authors: Mary A.M. Rogers, David Small, Debra A. Buchan, Carl A. Butch, Christine M. Stewart, Barbara E. Krenzer, Harold L. Husovsky
Journal: Annals of Internal Medicine (2001)

Technological advances in the distribution of information have opened new avenues for patient care. Few trials, however, have used telemedicine to improve blood pressure in patients with essential hypertension.To determine the efficacy of a telecommunication service in reducing blood pressure.Randomized, controlled trial.University-affiliated primary care outpatient clinics.121 adults with essential hypertension who were under evaluation for a change in antihypertensive therapy.A home service consisting of automatic transmission of blood pressure data over telephone lines, computerized conversion of the information into report forms, and weekly electronic transmission of the report forms to physicians and patients.24-hour ambulatory blood pressure monitoring at baseline and exit. The primary end point was change in mean arterial pressure from baseline to exit.Mean arterial pressure decreased by 2.8 mm Hg in patients receiving the home service and increased by 1.3 mm Hg in patients receiving usual care (P = 0.013 for the difference). Mean diastolic blood pressure decreased by 2.0 mm Hg for home service but increased by 2.1 mm Hg for usual care (P = 0.012 for the difference). Mean systolic blood pressure decreased by 4.9 mm Hg for home service and 0.1 mm Hg for patients receiving usual care (P = 0.047 for the difference). Among African-American patients, mean arterial pressure decreased by 9.6 mm Hg in those receiving home service and increased by 5.25 mm Hg in those receiving usual care (P = 0.047). Part of the decrease in blood pressure for home service was due to more frequent changes in the type or dose of antihypertensive medications.This telecommunication service was efficacious in reducing the mean arterial pressure of patients with established essential hypertension.
Leukocyte cell-derived chemotaxin 2 (LECT2)–associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States
Authors: Oana M. Mereuta, Jason D. Theis, Julie A. Vrana, Mark E. Law, Karen L. Grogg, Surendra Dasari, Vishal S. Chandan, Tsung-Teh Wu, Victor H. Jimenez-Zepeda, Rafael Fonseca, Angela Dispenzieri, Paul J. Kurtin, Ahmet Dogan
Journal: Blood (2014)
Clinicopathologic Correlations of Renal Biopsies in Hypertension with Pyelonephritis
Authors: JOSEPH C. MERRIAM, SHELDON C. SOMMERS, REGINALD H. SMITHWICK
Journal: Circulation (1958)

Analysis has been made of the responses to sympathectomy for hypertension and certain other aspects of 120 cases whose renal biopsies showed pyelonephritis as well as arteriolar nephrosclerosis. The sex incidence, mortality, average diastolic blood pressures, and post-operative kidney function tests differed from findings in larger hypertensive group without pathologic evidence of pyelonephritis.
NHS Commissioning Board needs targets for integrated care to become a reality, conference hears
Authors: C. White
Journal: BMJ (2012)

The right to integrated care should be enshrined in the NHS constitution if it is to become an integral part of the new NHS landscape and deliver much needed improvements in the quality of primary care provision, experts have claimed.

Speaking at a conference on the topic, organised by health policy think tank the King’s Fund on 10 January, its chief executive Chris Ham feared that the government’s response to the latest NHS Future Forum report on integrated care, published on Monday (http://healthandcare.dh.gov.uk/forum-report), was little more than hot air.

“There are lots of warm words and good intentions in the [Department’s] response, but very few specific credible commitments to actually do anything to make [it] a reality,” he said. Three things were needed, he suggested.

The mandate to the NHS Commissioning Board should include some …
Genetics and Cardiovascular Disease
Authors: Euan A. Ashley, Ray E. Hershberger, Colleen Caleshu, Patrick T. Ellinor, Joe G.N. Garcia, David M. Herrington, Carolyn Y. Ho, Julie A. Johnson, Steven J. Kittner, Calum A. MacRae, Gia Mudd-Martin, Daniel J. Rader, Dan M. Roden, Derek Scholes, Frank W. Sellke, Jeffrey A. Towbin, Jennifer Van Eyk, Bradford B. Worrall
Journal: Circulation (2012)

A lthough the power of family history to identify a genetic predisposition to disease has been appreciated for some time, it is only recently, through the development of efficient methods for molecular genotyping and specific genetic tests, that a detailed genetic evaluation could be used to influence clinical medicine.Indeed, the mapping of the human genome and the more recent development of high-throughput methodologies have the potential to entirely transform how we think about genetic predisposition to disease.This represents a great opportunity to improve human health.Yet these recent technological advances also create new moral, ethical, and legal challenges that must be addressed before the opportunities to improve human health can be fully realized.In the present report, we summarize the existing regulatory landscape with respect to the use of genetic information in clinical medicine and offer new policy recommendations designed to facilitate the safe incorporation of the latest technologies and research findings into the clinical domain.Specifically, we focus on areas in which genetic evaluation, including personal and family history, examination, counseling, and testing, has the potential to impact the practice of cardiovascular medicine and research.The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel.Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.
Employment problems and prospects for patients with inflammatory bowel disease.
Authors: R J Wyke, F C Edwards, R N Allan
Journal: Gut (1988)

A random sample of 170 patients (88 men) with chronic inflammatory bowel disease (75 ulcerative colitis) were first interviewed in 1978 about their employment status, problems at work, and influence of surgery. Surgery had been carried out on 120 and 53 had an ileostomy. After six years 144 (92%) of the 156 survivors replied to a follow up postal questionnaire. Of the initial sample, 122 (72%) were working and there were only three (1%) registered unemployed. After six years a similar proportion were working and only seven (5%) were unemployed. Continuity of employment was good with 57% in the same job. Changes in work because of health had been made by 72 patients mainly caused by bowel disease. After surgery 10% completely changed and 22% modified their work while a few had to retrain or retire. Panproctocolectomy and ileostomy resulted in more changes and longer time off work after surgery than colectomy and ileorectal anastomosis, with 35% and 17% respectively off work after one year. Problems at work, in particular general malaise and arthritis were experienced by 34 (28%) patients. Fewer problems were experienced by patients with a stoma who also had less sickness absence than those without a stoma. Colleagues and employers were usually supportive although some patients encountered discrimination especially those with a stoma or working in the food industry. Few patients had been counselled on their work. In general employment prospects and time off work were good and employers should be encouraged to take an optimistic and supportive role. Doctors should consider that convalescence after surgery may be longer than they perceive and must provide better counselling for patients.
Couples facing death. I-Psychosocial aspects.
Authors: A Stedeford
Journal: BMJ (1981)

Forty-one couples facing the prospect of separation by death were followed up from the time of admission to a continuing care unit through death of the patient to an interview with the bereaved spouse. Half the patients were found to have anxiety or depression or both, usually as a result of failure to cope with specific difficulties. These fell into four groups: unsatisfactory communication, direct effects of illness and treatment, failure to adjust lifestyles to changing circumstances, and pre-existing marital and family problems. This paper examines in detail the problems in the second and third groups. Support was offered to the patient and family in an attempt to help them to adjust and make the best use of their resources. The responses obtained suggest that some of the suffering of terminal illness can be relieved when psychosocial problems are recognised and appropriated help is given.