Postmenopausal Hormone Therapy and Cardiovascular Disease
Authors: Francine Grodstein, JoAnn E. Manson, Meir J. Stampfer
Journal: Annals of Internal Medicine (2001)

Letters18 December 2001Postmenopausal Hormone Therapy and Cardiovascular DiseaseFrancine Grodstein, ScD, JoAnn E. Manson, MD, and Meir J. Stampfer, MDFrancine Grodstein, ScDHarvard Medical School and Harvard School of Public Health; Boston, MA 02215Search for more papers by this author, JoAnn E. Manson, MDHarvard Medical School and Harvard School of Public Health; Boston, MA 02215Search for more papers by this author, and Meir J. Stampfer, MDHarvard Medical School and Harvard School of Public Health; Boston, MA 02215Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-12-200112180-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Kessler's attempt to further clarify the complicated decisions relating to HRT in postmenopausal women. However, we would like to stress that all such attempts (including our own) must be interpreted with great caution. Calculations such as those presented by Dr. Kessler will vary substantially depending on the individual woman's risk factors and assume that the relative risks applied are perfectly accurate and valid. In particular, the relative risk associated with 0.3 mg of estrogen and stroke in the Nurses' Health Study is based on relatively few stroke cases and thus is unstable (that is, the ...References1. Grady D, Rubin SM, Petitti DB, Fox CS, Black D, Ettinger B, et al . Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med. 1992;117:1016-37. [PMID: 1443971] LinkGoogle Scholar2. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, et al . Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA. 1998;280:605-13. [PMID: 9718051] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Francine Grodstein, ScD; JoAnn E. Manson, MD; Meir J. Stampfer, MDAffiliations: Harvard Medical School and Harvard School of Public Health; Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Prospective, Observational Study of Postmenopausal Hormone Therapy and Primary Prevention of Cardiovascular Disease Francine Grodstein , JoAnn E. Manson , Graham A. Colditz , Walter C. Willett , Frank E. Speizer , and Meir J. Stampfer Postmenopausal Hormone Therapy and Cardiovascular Disease Kenneth M. Kessler Postmenopausal Hormone Therapy and Cardiovascular Disease Carsten Otto and Klaus Parhofer Metrics 18 December 2001Volume 135, Issue 12Page: 1093-1094KeywordsCardiovascular diseasesHormonal therapyHormonesMedical risk factorsObstetrics and gynecologyOsteoporosisPulmonary embolismQuestionnairesRelative riskStroke ePublished: 18 December 2001 Issue Published: 18 December 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...