tbuckley/cabot-search huggingface dataset:
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia
Authors: Daniel C. Link, Ghada Kunter, Yumi Kasai, Yu Zhao, Tracie Miner, Michael D. McLellan, Rhonda E. Ries, Deepak Kapur, Rakesh Nagarajan, David C. Dale, Audrey Anna Bolyard, Laurence A. Boxer, Karl Welte, Cornelia Zeidler, Jean Donadieu, Christine Bellanné-Chantelot, James W. Vardiman, Michael A. Caligiuri, Clara D. Bloomfield, John F. DiPersio, Michael H. Tomasson, Timothy A. Graubert, Peter Westervelt, Mark Watson, William Shannon, Jack Baty, Elaine R. Mardis, Richard K. Wilson, Timothy J. Ley
Journal: Blood (2007)
Alteration of Endothelium-Dependent Hyperpolarizations in Porcine Coronary Arteries With Regenerated Endothelium
Authors: Catherine Thollon, Jean P. Bidouard, Christine Cambarrat, Isabelle Delescluse, Nicole Villeneuve, Paul M. Vanhoutte, Jean P. Vilaine
Journal: Circulation Research (1999)

The present study was designed to test the ability of regenerated endothelium to evoke endothelium-dependent hyperpolarizations. Hyperpolarizations induced by serotonin and bradykinin were compared in isolated porcine coronary arteries with native or regenerated endothelium, 4 weeks after balloon endothelial denudation. The experiments were performed in the presence of inhibitors of nitric oxide synthase (Nomega-nitro-L-arginine) and cyclooxygenase (indomethacin). The transmembrane potential was measured using conventional glass microelectrodes. Smooth muscle cells from coronary arteries with regenerated endothelium were depolarized in comparison with control coronary arteries from the same hearts. Spontaneous membrane potential oscillations of small amplitude or spikes were observed in some of these arteries but never in arteries with native endothelium. In coronary arteries from control pigs, both serotonin and bradykinin induced concentration-dependent hyperpolarizations. In the presence of ketanserin, 10 micromol/L serotonin induced a transient hyperpolarization in control coronary arteries. Four weeks after balloon denudation, the response to serotonin was normal in arteries with native endothelium, but the hyperpolarization was significantly lower in coronary arteries with regenerated endothelium. In control arteries, the endothelium-dependent hyperpolarization obtained with bradykinin (30 nmol/L) was reproducible. Four weeks after balloon denudation, comparable hyperpolarizations were obtained in coronary arteries with native endothelium. By contrast, in arteries with regenerated endothelium, the hyperpolarization to bradykinin became voltage-dependent. In the most depolarized cells, the hyperpolarization to bradykinin was augmented. The changes in resting membrane potential and the alteration in endothelium-dependent hyperpolarizations observed in the coronary arteries with regenerated endothelium may contribute to the reduced response to serotonin and the unchanged relaxation to bradykinin described previously.
Basic Radiology
Authors: Richard H. Chamberlain
Journal: JAMA (1970)

In modern medical practice, it has been estimated that between one third to one half of all crucial medical decisions are dependent on radiological information.<sup>1</sup>However, in view of the relatively expensive outlays required for equipment and supplies and the high level of professional training needed to extract full advantage from it, only approximately one sixth of the world's peoples has access to fully modern radiology, one sixth is rapidly approaching such development, and the remaining 2.5 billion persons are largely beyond its reach. It is high time to examine critically how to obtain the most benefit for the most people within feasible developments in diagnostic radiology. In view of the many elements to be considered, the approach of total systems engineering must be used. All over the world, including the United States, a large proportion of diagnostic x-ray films are of inferior quality.<sup>2</sup>They are uncertainly exposed,
Effect of late postoperative atrial septal defect closure on hemodynamic function in patients with a lateral tunnel fontan procedure
Authors: Micheal A. Kuhn, Jay M. Jarmakani, Hillel Laks, Juan C. Alejos, Lester C. Permut, Alvaro Galindo, Josephine B. Isabel-jones
Journal: Journal of the American College of Cardiology (1995)
REPRODUCIBILITY OF PLASMA AND EXTRACELLULAR FLUID VOLUME MEASUREMENTS IN CRITICALLY ILL PATIENTS
Authors: P. Ernest, C. D. Deane, N. G. Hartman, K. F. Cunningham, A. S. Belzberg, P. Dodek
Journal: Clinical Nuclear Medicine (1991)

Ernest, P.; Deane, C. D.; Hartman, N. G.; Cunningham, K. F.; Belzberg, A. S.; Dodek, P. Author Information
Defibrillators in Public Places — One Step Closer to Home
Authors: W Douglas Weaver, Mary Ann Peberdy
Journal: New England Journal of Medicine (2002)

At least 450,000 cases of unexpected cardiac arrest occur annually in the United States (Figure 1). The majority occur in places other than hospitals in people with recognized heart disease. However, the accurate identification of potential victims is not possible, and sudden death is often the initial manifestation of cardiac disease. Most such events occur at home, but up to a quarter occur in public places and are often witnessed by trained personnel who attempt resuscitation. Prompt defibrillation is the most important determinant of survival. Years ago, observations from a Seattle cardiac-rehabilitation program showed that the survival rate was almost . . .
Studies on Renin
Authors: Harry Goldblatt, Erwin Haas, Robert Haas
Journal: Circulation Research (1972)

We have devised a method of evaluation, in terms of Goldblatt units (GU), of the data obtained in various laboratories for the excretion of renin from canine and human kidneys. An average value of 1.3 x 10 -4 GU/min g -1 normal renal tissue resulted for both dog and man. A blood pressure increase of 18-45 mm Hg was induced in normal or nephrectomized, conscious or anesthetized dogs by the continuous infusion of homologous renin at even lower rates (0.25-0.50 x 10 -4 GU/min g -1 renal tissue), i.e., at 20-40% of the rate excreted by the kidney. This suggests that renin, even at its normal rate of excretion from the kidney, participates in the maintenance of normal blood pressure. The increase of blood pressure and of concentration of renin in the dog's blood was measured at infusion rates ( C ) of 0.0042, 0.0083, 0.0167, 0.0333, and 0.0667 GU/min. At each rate, after a fixed period of infusion ( t = 60 minutes), a constant fraction (54% of the infused renin) was retained in the circulation. From this and the results of infusion experiments carried out for 30, 60, and 120 minutes, the total amount of exogenous renin, R , present in the circulation at time t can be expressed as R = C/K (1 - e -Kt ). K = 0.0232 minutes -1 and represents the fraction of exogenous and, presumably, also endogenous renin that is being eliminated from the circulation of the normal dog per minute. Thus, the time required for removal of 50% of the renin from the blood is t ½ = log e 2/ K = 30 minutes.
Convulsions associated with prophylactic antimalarial drugs: implications for people with epilepsy.
Authors: D. R. Fish, M. L. Espir
Journal: BMJ (1988)

incidence of 1 in 7 5 compared with 1 in 160 men by age 25 as reported by Williamson.2Further evidence that these patients form a high risk group for torsion is provided by other authors who have noted a history of recurrent testicular pain before torsion in 29-50% of their patients.34Recognition of this diagnosis, its relation to acute torsion and urgent elective orchidopexy may improve testicular salvage rates.The occurrence of one case of torsion despite previous fixation with absorbable sutures suggests that fixation should be achieved with three non-absorbable sutures in addition to plication of the tunica vaginalis.
Treatment of biliary obstruction in selected patients by endoscopic ultrasonography (EUS)-guided transluminal biliary drainage
Authors: U. Will, A. Thieme, F. Fueldner, R. Gerlach, I. Wanzar, F. Meyer
Journal: Endoscopy (2007)

Endoscopic retrograde cholangiopancreatography (ERCP)-guided implantation of a biliary endoprosthesis or stent is the gold standard treatment for biliary obstructions. When the papilla cannot be traversed because there is pyloric or duodenal stenosis, or the catheter cannot be introduced, or because of previous gastrointestinal surgery (Billroth II gastric resection, Whipple procedure, gastrectomy with Roux-en-Y reconstruction), the alternative treatment is considered to be percutaneous transhepatic cholangiography and drainage (PTCD). The aim of the study was to investigate the further alternative of endoscopic ultrasound (EUS)-guided transgastric or transjejunal biliary drainage where PTCD failed or was declined, and particularly, the feasibility and outcome of this option.Over 3 years all appropriate consecutive patients (as defined above) were enrolled in this prospective, observational, single-center, case series study, and patient and intervention data were recorded. Feasibility was characterized by success rate (regression of cholestasis), and outcomes by complication rate, mortality, and follow-up findings.Between November 2002 and December 2005, eight patients (in 10 interventions) underwent this new biliary drainage procedure. The routes were transesophageal (n = 1), transgastric (n = 4), and transjejunal (n = 3, including a rendezvous technique with ERCP [n = 1]). The indications were cholestasis, arising from recurrent tumor growth (n = 5, 62.5%), that included gastric carcinoma after previous gastrectomy (n = 4) and a periampullary carcinoma after previous Whipple procedure (n = 1); arising from Klatskin tumor (n = 2, 25%); and from benign stenosis of a hepaticojejunostomy (n = 1, 12.5%). Five patients (62.5%) received a metal stent, and three (37.5%) had a plastic prosthesis (8.5-Fr double-pigtail). The technical success rate was 90% (9/10) and the clinical success rate was 88.9% (8/9). There was only one case of cholangitis (12.5%) and slight postinterventional pain, but no severe complications such as bleeding or perforation, and no mortality. During follow-up (range 4 weeks to 3 years) re-interventions were needed in two patients (20%) because of increasing cholestasis; these resulted in technical success and clinical improvement.EUS-guided transgastric or transjejunal biliary drainage is a reasonable, feasible and encouraging treatment option in selected patients as indicated, with a low peri-interventional risk. It broadens the therapeutic spectrum but still needs further evaluation and follow-up investigation.
RELATION OF FEDERAL, STATE AND MUNICIPAL GOVERNMENTS TO HOSPITAL MAINTENANCE
Authors: WILLIAM GERRY MORGAN
Journal: JAMA (1930)

In the capital city of the nation, where I have the privilege and good fortune to practice my profession, medical men are confronted with a situation which has to be met in other cities of our country but which I think prevails to a much greater degree in Washington than elsewhere; namely, providing hospitalization for a class of patients whose incomes are barely sufficient for the actual necessities of existence. When hospitalization for such individuals becomes necessary it entails a hardship and a crisis difficult for the majority of them to meet. It has been stated, and is borne out in fact, that 70 per cent ofour population face the bugbear of having to meet extra expenses annually on account of illnesses requiring expenditures sufficiently large to impose a serious financial burden. Of this number 50 per cent are hospitalized annually. If from the 70 per cent is deducted the
New Indirect Approach to the Therapeutic Use of Immunotoxins
Authors: O. Fodstad, G. Kvalheim, A. Pihl, A. Godal, S. Funderud
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article New Indirect Approach to the Therapeutic Use of Immunotoxins Get access Øystein Fodstad, Øystein Fodstad 3Insitute for Cancer Research, The Norwegian Radium HosopitalMontebello, 0310 Oslo 3, Norway. Search for other works by this author on: Oxford Academic PubMed Google Scholar Gunnar Kvalheim, Gunnar Kvalheim 3Insitute for Cancer Research, The Norwegian Radium HosopitalMontebello, 0310 Oslo 3, Norway. Search for other works by this author on: Oxford Academic PubMed Google Scholar Alexander Pihl, Alexander Pihl 3Insitute for Cancer Research, The Norwegian Radium HosopitalMontebello, 0310 Oslo 3, Norway. Search for other works by this author on: Oxford Academic PubMed Google Scholar Aslak Godal, Aslak Godal 3Insitute for Cancer Research, The Norwegian Radium HosopitalMontebello, 0310 Oslo 3, Norway. Search for other works by this author on: Oxford Academic PubMed Google Scholar Steinar Funderud Steinar Funderud 3Insitute for Cancer Research, The Norwegian Radium HosopitalMontebello, 0310 Oslo 3, Norway. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 6, 18 May 1988, Pages 439–443, https://doi.org/10.1093/jnci/80.6.439 Published: 18 May 1988 Article history Received: 11 February 1988 Accepted: 22 February 1988 Published: 18 May 1988
Results, Potential Effects, and Implementation Issues of the Resource-Based Relative Value Scale
Authors: William C. Hsiao
Journal: JAMA (1988)

This article presents the overall results of the Resource-Based Relative Value Scale (RBRVS) study. We present resource-based relative values for selected services in each of the 18 specialties we studied. We found that preservice and postservice work represents close to 50% of total work for invasive services and 33% of total work for evaluation/management services. We also found that the work per unit time (a measure of intensity) for invasive services is about three times that of evaluation/management. We developed a simple model and simulated an RBRVS-based fee schedule for the Medicare program under a "budget-neutral" assumption. Results for 30 commonly performed services show that office visit fees for evaluation/management services could rise by 70%, while some surgical fees could drop by 60%. We also simulated what the Medicare outlays would have been in 1986 for categories of medical services under an RBRVS-based fee schedule. We found that total Medicare payments for evaluation/management services would have increased by about 56%. Invasive, imaging, and laboratory services would have decreased by 42%, 30%, and 5%, respectively. We also discuss implementation issues related to an RBRVS-based fee schedule, such as the determination of a monetary conversion factor, practice costs, billing codes, and the need to evaluate the potential impacts of an RBRVS-based payment system on the cost and quality of health care. (<i>JAMA</i>1988;260:2429-2438)
Lean Body Mass Is Better Than Body Surface Area in Correcting GFR
Authors: Hongwei Si, Zhili Lei, Sijin Li, Jianzhong Liu, Jianhua Geng, Shengzu Chen
Journal: Clinical Nuclear Medicine (2012)

Purpose The Gates-based renography (gGFR) and plasma-based clearance rate (pGFR) are conventionally corrected with body surface area (BSA). Limited studies indicated that the lean body mass (LBM) might be better than BSA in correcting pGFR. Therefore, we suggest that LBM is also better in correcting gGFR and improve the correlation coefficient between gGFR and pGFR. Method During June 2009 and December 2010, the gGFR and pGFR of 63 patients with hydronephrosis were measured and corrected with BSA and LBM, respectively. The correlation and regression analyses were conducted to illustrate the power of BSA and LBM correction. Results In a paired t test, there was no significant difference between pGFR and gGFR in patients with stages 1 and 2, although this was significant in stages 3 and 4. However, neither LBM nor BSA correction could eliminate the difference. In all patients (N = 63), the correlation coefficient (r) between pGFR and gGFR was 0.794 (P <; 0.001). After the BSA and LBM correction, r was improved to 0.809 and 0.828, respectively. In all patients, the regression line of pGFRLBM − gGFRLBM was nearer to the original point and its slope closer to 1 than pGFRBSA − gGFRBSA and pGFR − gGFR. Similar results were found in the analysis of most stages and subgroups. Conclusions The commonsense of BSA correction should be seriously reevaluated. Lean body mass can better improve the correlation coefficient between paired GFRs than BSA can and it can be suitable in the correction.
New CAM Database Online
Authors: Brian Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In vivo examination of lentigo maligna and malignant melanoma in situ, lentigo maligna type by near-infrared reflectance confocal microscopy: Comparison of in vivo confocal images with histologic sections
Authors: Zeina S. Tannousa,b, Martin C. Mihma, Thomas J. Flottea, Salvador Gonzálezb
Journal: Journal of the American Academy of Dermatology (2002)
Naproxen in Rheumatoid Arthritis
Authors: ZUCKER NORMAN
Journal: Annals of Internal Medicine (1976)

Comments1 September 1976Naproxen in Rheumatoid ArthritisZUCKER NORMAN, M.D.ZUCKER NORMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-400 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to comment on "Naproxen in Rheumatoid Arthritis" (Ann Intern Med 83:470-475, 1975), since no letters have been published on it of yet.When representatives of drug companies visit me in my office, I must make decisions about the validity of their statements. I therefore generally ask for reprints of articles in major journals that are not wholly supported by the company's money. I am therefore quite disappointed to find an article in your journal (which I consider to be the best in the field and which I read from cover to cover) from Syntex Laboratories....References1. RODNANMCEWENWALLACE GCS (editors): Rheumatoid arthritis, in Primer on the Rheumatic Diseases. JAMA 224 (suppl): 696-697, 1973 Google Scholar2. BAYLE T: Salicylate therapy for rheumatoid arthritis, in Arthritis and Allied Conditions, 8th ed., edited by HOLLANDER JL, MCCARTY DJ. Philadelphia, Lea and Febiger, 1972, pp. 451-453 Google Scholar3. WOODBURY D: Analgesic-antipyretics, anti-inflammatory agents, and inhibitors of uric acid synthesis, in The Pharmacologic Basis of Therapeutics, 4th ed., edited by GOODMAN LG, GILMAN A. New York, The Macmillan Company, 1970, p. 326 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 2004 Main St., Suite 201 Forest Grove, OR 97116 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byP 1 September 1976Volume 85, Issue 3Page: 400-401KeywordsDrugsRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 September 1976 PDF downloadLoading ...
Differential Effects of Endothelin Receptor Activation on Cyclic Flow Variations in Rat Mesenteric Arteries
Authors: Kenichi Fujise, Lowell Stacy, Pamela Beck, Edward T.H. Yeh, Alice Chuang, Tommy A. Brock, James T. Willerson
Journal: Circulation (1997)

Background Cyclic flow variations (CFVs) represent repetitive cycles of platelet adherence–aggregation and vasoconstriction, followed by dislodgment of platelet thrombi and restoration of blood flow at the site of vascular injury. Although activation of endothelin A (ETA) and endothelin B (ETB) receptors leads to vasoconstriction and nitric oxide release, respectively, the roles of endogenous endothelin-1 (ET-1) and its receptors in CFVs are unknown. Methods and Results A side branch of a mesenteric artery of male Wistar rats was cannulated and a short segment of the artery was mechanically injured to induce CFVs. After 20 minutes of saline infusion, either saline (negative control), BQ-123 (ETA receptor antagonist, 10 μg/min), BQ-788 (ETB receptor antagonist, 10 μg/min), or sarafotoxin S6c (ETB receptor agonist, 10 ng/min) was infused for 20 minutes from the side branch into the injured arterial segment. Percent (%) luminal stenosis as well as proximal and distal vessel diameters were observed and quantitatively measured every minute using intravital video microscopy and a micrometer-calibrated video screen. Both BQ-123 and sarafotoxin S6c significantly reduced CFVs represented by the mean luminal stenosis (BQ-123=29±13% and sarafotoxin S6c=27±11% reduction, respectively; P &lt;.05 for both, compared with saline). In contrast, BQ-788 significantly increased CFVs (33±6% increase, P &lt;.05 compared with saline). Moreover, the inhibitory effect of sarafotoxin S6c on CFVs was completely abolished in the presence of N ω -nitro- l -arginine methyl ester (L-NAME) (a nitric oxide synthase inhibitor, 10 −5 mol/L) in superfusate over the arteries (16.1±5% increase, P =NS compared with saline in the presence of L-NAME). In addition, BQ-123 caused a significant increase in the diameter of the vessel distal to the injured segment (12±4% increase, P &lt;.05 compared with saline). Conclusions Endogenous ET-1 release from sites of vascular injury contributes to CFVs and vasomotor tone in the rat mesenteric artery CFV model. ETA and ETB receptors have differential roles in CFVs: ETA receptor antagonism and ETB receptor stimulation reduce CFVs, the latter at least partially through increased nitric oxide formation.