tbuckley/cabot-search huggingface dataset:
Experimental myocardial ischemia. IV. Shape and volume changes during "isolvolumetric relaxation" in normal and ischemic ventricles.
Authors: F X Van Houten, J R Serur, D M Borkenhagen, D F Adams, H L Abrams
Journal: Circulation (1980)

Shape and volume changes were studied in mongrel dogs between end-systole and mitral valve opening (MVO). Biplane left ventricular cineangiograms were performed at 200 frames/sec. The dogs were studied during the control state and during regional myocardial ischemia produced by balloon occlusion of the left anterior descending coronary artery. Outward wall motion, called pre-inflow relaxation (PIR), occurred in all 10 dogs in the control state, most frequently in the apical (seven of 10) and equatorial planes (seven of 10). PIR was seen less frequently during ischemia (13 of 40 measurements vs 19 of 40 measurements during control state), usually in the basal plane (five of 10). The ventricular volume between end-systole and MVO increased in all 10 dogs during the control state (mean increment 4.4 +/- 0.7 ml). Volume increased in eight of 10 dogs during ischemia (mean increment 3.0 +/+ 1.1 ml). The characteristic patterns of wall motion occurring between end-systole and MVO are altered by regional myocardial ischemia. During ischemia PIR occurs in segments of the myocardium with normal perfusion, but usually not in ischemic segments. Biplane ventricular volume between end-systole and MVO increased in 18 of 20 measurements (mean increment 3.6 +/- 0.9 ml).
Mechanisms of lumen enlargement during stenting of acute myocardial infarction lesions: A volumetric intravascular ultrasound study
Authors: Jun-ichi Kotani, Gary S. Mintz, Chalak O. Berzingi, Jerzy Pregowski, Lukasz Kalinczuk, Augusto D. Pichard, Lowell F. Satler, Ron Waksman, William O. Suddath, Kenneth M. Kent, Neil J. Weissman
Journal: Journal of the American College of Cardiology (2003)
Colostomies May Influence Patient Quality of Life More Than Poor Sphincter Function
Authors: Jacqueline Kerr, Jutta Engel, Dieter Hölzel, Bruce D. Minsky
Journal: Journal of Clinical Oncology (2002)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.02.142 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12228215 Colostomies May Influence Patient Quality of Life More Than Poor Sphincter Function Jacqueline KerrxJacqueline KerrSearch for articles by this author , Jutta EngelxJutta EngelSearch for articles by this author , Dieter HölzelxDieter HölzelSearch for articles by this author Bruce D. MinskyxBruce D. MinskySearch for articles by this author Show More Munich Cancer Registry, Ludwig Maximillians University, Munich, GermanyMemorial Sloan-Kettering Cancer Center, New York, NY https://doi.org/10.1200/JCO.2002.02.142 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical OncologyjcoJ Clin OncolJournal of Clinical OncologyJCO0732-183X1527-7755American Society of Clinical OncologyResponse15092002In Reply:I wish to thank Dr Kerr et al for sharing their quality-of-life (QOL) data. It is not unexpected that their experience differs from that of Grumann et al.1 In general, the more carefully sphincter function and QOL are examined, the more confusing and contradictory they become. It must be emphasized that although QOL tools are validated, they remain subjective. For example, one patient’s preference for bowel frequency and urgency in lieu of a permanent colostomy may be another patient’s anathema.Nonetheless, we need to continue to carefully evaluate functional end points in rectal cancer clinical trials. The data from Dr Kerr et al help us continue with these efforts, and I welcome their comments.REFERENCE1. Grumann MM, Noack EM, Hoffmann IA, et al: Comparison of quality of life in patients undergoing abdominoperineal extirpation or anterior resection for rectal cancer. Ann Surg 233:: 149,2001-156, Crossref, Medline, Google Scholar
Compound Fracture of the Femur, Erysipelas, Pyaemia; Amputation of the Thigh: Subsequent Exarticulation at the Hip: Complete Recovery
Authors: A. E. Barker
Journal: BMJ (1883)

lscem (d.e: 4,517 10.77 76 7.56 13 3.3 89 6.36 Ob~edc Macera(diseeof) .... .... 1,75 4.0 264 16
Accuracy of Precordial Percussion and Palpation
Authors: David H. Spodick
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Those of us long devoted to investigating and improving the quality of bedside diagnosis<sup>1</sup>always welcome articles like that of Dr Heckerling and colleagues<sup>2</sup>who evaluated precordial percussion and palpation using ultrafast computed tomography as a standard. Although appropriate statistical methods, particularly the receiver operator characteristic and the κ value, were used, one wonders whether the investigative method was appropriate for a fair evaluation of the techniques studied. My principal concern is this: was there a sufficient number of bedside investigators, especially since the second investigator evaluated an undefined subset of only 14 patients, compared with 103 patients by the principal investigator? Even with good concordance on their common 14 patients as indicated by the Landis-Koch observer agreement scale, should there not have been at least three observers, each blindly evaluating the entire series? Observer variability, even among recognized experts (analyzed elsewhere),<sup>3</sup>can be
Something From My Life
Authors: M. Wyrebek
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012
Authors: Tannaz Moin, Jinnan Li, O. Kenrik Duru, Susan Ettner, Norman Turk, Abigail Keckhafer, Sam Ho, Carol M. Mangione
Journal: Annals of Internal Medicine (2015)

Prediabetes affects 1 in 3 Americans. Both intensive lifestyle intervention and metformin can prevent or delay progression to diabetes. Over the past decade, lifestyle interventions have been translated across various settings, but little is known about the translation of evidence surrounding metformin use.
CD14 polymorphisms and serum CD14 levels through childhood: A role for gene methylation?
Authors: Monica Cheng Munthe-Kaas, Tale Mæhre Torjussen, Kristina Gervin, Karin C. Lødrup Carlsen, Kai Håkon Carlsen, Berit Granum, Hanne Sagsveen Hjorthaug, Dag Undlien, Robert Lyle
Journal: Journal of Allergy and Clinical Immunology (2010)
TCT-497 Arterial Media Preservation Associated with The Paradise Ultrasound Renal Denervation System: A Next generation Approach for Treating Resistant Hypertension
Authors: Elena Ladich, Leslie Coleman, Vincent Cabane, Kenichi Sakakura, Fumiyuki Otsuka, Peter Markham, Renu Virmani
Journal: Journal of the American College of Cardiology (2013)
A Fatal Case of Babesiosis in Missouri: Identification of Another Piroplasm That Infects Humans
Authors: Barbara L. Herwaldt
Journal: Annals of Internal Medicine (1996)

Objective: To characterize the etiologic agent (MO1) of the first reported case of babesiosis acquired in Missouri. Design: Case report, serologic testing, animal inoculations, and molecular studies. Setting: Southeastern Missouri. Patient: A 73-year-old man who had had a splenectomy and had a fatal case of babesiosis. Measurements: Serum specimens from the patient were assayed by indirect immunofluorescent antibody testing and immunoprecipitation for reactivity with antigens from various Babesia species. Whole blood obtained from the patient before treatment was inoculated into hamsters and jirds and into calves and bighorn sheep that had had splenectomy and were immunosuppressed with dexamethasone. Piroplasm-specific nuclear small-subunit ribosomal DNA was recovered from the patient's blood by using broad-range amplification with the polymerase chain reaction; a 144 base-pair region of the amplification product was sequenced; and phylogenetic analysis was done to compare MO1 with various Babesia species. Results: Indirect immunofluorescent antibody testing showed that the patient's serum had strong reactivity with Babesia divergens, which causes babesiosis in cattle and humans in Europe, but that it had minimal reactivity with B. microti and WA1, which are the piroplasms previously known to cause zoonotic babesiosis in the United States. Immunoprecipitations showed that MO1 is more closely related to B. divergens than to B. canis (a canine parasite). None of the experimentally inoculated animals became demonstrably parasitemic. Phylogenetic analyses, after DNA sequencing, showed that MO1 is most closely related to B. divergens (100% similarity). Conclusions: Although MO1 is probably distinct from B. divergens, the two share morphologic, antigenic, and genetic characteristics; MO1 probably represents a Babesia species not previously recognized to have infected humans. Medical personnel should be aware that patients in the United States can have life-threatening babesiosis even though they are seronegative to B. microti and WA1 antigen.
Robot-Assisted Uretero-Ureterostomy for Iatrogenic Lumbar and Iliac Ureteral Stricture: Technical Details and Preliminary Clinical Results
Authors: Nicolòmaria Buffi, Andrea Cestari, Giovanni Lughezzani, Piera Bellinzoni, Mattia Sangalli, Emanuele Scapaticci, Matteo Zanoni, Filippo Annino, Alessandro Larcher, Massimo Lazzeri, Patrizio Rigatti, Giorgio Guazzoni
Journal: European Urology (2011)
The Metabolic Derangements and Treatment of Diabetic Ketoacidosis
Authors: D W Foster, J D McGarry
Journal: New England Journal of Medicine (1983)

Diabetic ketoacidosis is a common illness among patients with diabetes. The exact prevalence is unknown, but in one community the rate was estimated to be 13.4 episodes per 1000 patient-years in young persons with diabetes.1 It remains a serious event, with mortality rates as high as 6 to 10 per cent.2 , 3 In children under 10 years of age, diabetic ketoacidosis accounts for 70 per cent of diabetes-related deaths.4 Death may be due to derangements that are directly attributable to ketoacidosis, to complications associated with the illness itself, or to abnormalities induced by treatment. Because a substantial percentage of deaths is . . .
Immunogenicity of Recombinant Yeast-Derived Hepatitis B Vaccine in Nonresponders to Perinatal Immunization
Authors: K. L. Tan
Journal: JAMA (1994)

Nonresponse to hepatitis B vaccine in the perinatal period occasionally occurs. This report documents the results of reimmunization of nonresponders to perinatal immunization.From a cohort of 1154 infants immunized with plasma-based vaccine in the perinatal period and followed up for more than 8 years, 45 nonresponders were identified. These children were reimmunized at 4 years of age. Each child received a yeast-derived recombinant hepatitis B vaccine on a 0-, 1-, and 5-month schedule, 33 children with 10-micrograms and 12 with 5-micrograms doses. Blood was sampled 1 month after the third vaccination and thereafter at 1, 2, and 4 years.The follow-up clinic where the cohort of children was regularly seen.Forty-five 4-year-old children who had no antibody to hepatitis B despite perinatal immunization.Antibody levels to hepatitis B surface antigen.Seroconversion with titers higher than 10 mIU/mL occurred in all children. More than 70% still had titers higher than 10 mIU/mL 4 years after vaccination.Nonresponders to perinatal hepatitis B vaccination respond well to subsequent vaccination.
Patterns of Depression in Chronic Illness
Authors: Nicholas A. Covino, Jerald F. Dirks, Robert A. Kinsman, John V. Seidel
Journal: Psychotherapy and Psychosomatics (1982)

An understanding of the existence and action of depression is essential to the medical management of patients with chronic illness. This study found thirteen unique patterns of depression in depressed persons being treated for chronic medical conditions. Of the 132 persons sampled, 96.2% fell clearly into one of these groups. The fact that these people manifested their clinical depression in such a variety of ways argues against a unilateral approach to the treatment of affective distress among those with a chronic medical illness. While patients manifest their affective distress in a variety of ways, self-esteem issues are significantly involved in almost half of the identified patterns.
South African doctors demand action on "unethical" colleagues
Authors: P. Sidley
Journal: BMJ (1999)

Several South African doctors are considering taking action to force the Health Professions Council to initiate an investigation into the conduct of the doctor who headed up the apartheid government's chemical and biological warfare programme.

They are also asking the council, which is the statutory body governing the medical, dental, and other health professions, to take action against a list of doctors implicated in unethical conduct in testimony before the Truth and Reconciliation Commission.

Dr Wouter Basson is a cardiologist who is being tried for …
Comparison of transesophageal echocardiography-detected thromboembolic risk markers in patients with chronic atrial fibrillation and atrial tachycardia according to the SPAF clinical risk stratification: a prospective study
Authors: Nadia Benyounes, Valérie Rozenberg, Lydia Djaouti, Charles Smadja, Mohammed Khirredine, Ariel Cohen
Journal: Journal of the American College of Cardiology (2002)
Angiotensin II-induced cardiac fibrosis in the rat is increased by chronic inhibition of nitric oxide synthase.
Authors: J Hou, H Kato, R A Cohen, A V Chobanian, P Brecher
Journal: Journal of Clinical Investigation (1995)

These studies were performed to determine if the effects of angiotensin II infusion on the development of cardiac fibrosis could be modified by the chronic inhibition of nitric oxide synthase activity. NG-nitro-L-arginine-methyl ester (L-NAME) was administered to adult Wistar rats in drinking water (40 mg/kg per d). Although blood pressure was maintained at hypertensive levels after 2 wk, cardiac hypertrophy or fibrosis did not occur. Angiotensin II, given for 3 d at a dose which induced little or no blood pressure elevation and minimal if any fibrosis, caused significant fibrosis when given to a rat pretreated for 2 wk with L-NAME. This marked fibrosis did not occur if angiotensin II was given shortly after L-NAME treatment was begun or briefly after discontinuation of L-NAME. The fibrosis that occurred with combined treatment was characterized by increased immunodetectable fibronectin, the presence of inflammatory cells within interstitial and perivascular regions, and increased steady state mRNA levels for matrix genes and atrial natriuretic protein. The data indicated a regulatory role for nitric oxide in modulating the angiotensin II-induced cardiac fibrosis and suggest a potentially important autocrine or paracrine role for nitric oxide in fibroblast proliferation.
Nigerian immunisation programme accused of distributing expired vaccines
Authors: A. Raufu
Journal: BMJ (2003)

Nigeria's immunisation programme has run into a controversy as the country's National Agency for Food and Drug Administration began investigating allegations that an expired antityphoid vaccine, Vivotif Berna, was distributed and administered in some parts of the country.

The vaccine, which was prepared in August 2002, carries an expiry date of 31 August 2003. But critics says that the vaccine stocks were kept too long in the stores of the National Programme on Immunisation before distribution began in the city of Jos and the surrounding area, in the centre of Nigeria, in late August 2003 and even up until the beginning …
Detecting bacteriuria in a primary maternal and child health care programme
Authors: K S Joseph, K N Brahmadathan, S. Abraham, A. Joseph
Journal: BMJ (1988)

Urinary tract infection in pregnancy has not been adequately dealt with in developing countries, though its consequences are well recognised. This is primarily because of constraints on resources coupled with a lack of technological infrastructure. An evaluation of the Griess test for the mass screening of urinary tract infection among antenatal women was carried out prospectively using a case-control method. The Griess test was found to be a valid, reliable, and economical screening test for urinary tract infection which can be integrated into a primary maternal and child health care programme.
Overcoming Resistance to Interferon-Induced Apoptosis of Renal Carcinoma and Melanoma Cells by DNA Demethylation
Authors: Frederic J. Reu, Soo In Bae, Leonid Cherkassky, Douglas W. Leaman, Daniel Lindner, Normand Beaulieu, A. Robert MacLeod, Ernest C. Borden
Journal: Journal of Clinical Oncology (2006)

Epigenetic editing of gene expression by aberrant methylation of DNA may help tumor cells escape attack from the innate and acquired immune systems. Resistance to antiproliferative effects and apoptosis induction by interferons (IFNs) was postulated to result from silencing of IFN response genes by promoter hypermethylation. Treatment of human ACHN renal cell carcinoma (RCC) and A375 melanoma cells with the DNA demethylating nucleoside analog 5-AZA-2'-deoxycytidine (5-AZA-dC) synergistically augmented antiproliferative effects of IFN- alpha (alpha) 2 and IFN-beta (beta). Either 5-AZA-dC or an antisense to DNA methyltransferase 1 (DNMT1) overcame resistance to apoptosis induction by IFNs with up to 85% apoptotic cells resulting from the combinations. No similar potentiation occurred in normal kidney epithelial cells. IFN response genes were augmented more than 10 times in expression by 5-AZA-dC. Demethylation by 5-AZA-dC of the promoter of the prototypic, apoptosis-associated IFN response gene XAF1 was confirmed by methylation-specific polymerase chain reaction. siRNA to XAF1 inhibited IFN-induced apoptosis; conversely, overexpression of XAF1 overcame resistance to apoptosis induction by IFN-beta. As occurred with apoptosis-resistant melanoma cells in vitro, tumor growth inhibition in the nude mouse of human A375 melanoma xenografts resulted from treatment with 5-AZA-dC in combination with IFN-beta, an effect not resulting from either single agent. The importance of epigenetic remodeling of expression of immune-modifying genes in tumor cells was further suggested by identifying reactivation of the cancer-testis antigens MAGE and RAGE in ACHN cells after DNMT1 depletion. Thus, inhibitors of DNMT1 may have clinical relevance for immune modulation by augmentation of cytokine effects and/or expression of tumor-associated antigens.
Course and prognosis of ulcerative colitis: Part III Complications
Authors: F. C. Edwards, S. C. Truelove
Journal: Gut (1964)

Part III ComplicationsOne of the outstanding features of ulcerative colitis is the diversity of complications of the disease.They fall logically into two main groups: local complications in and around the large bowel, and remote or systemic complications affecting distant parts of the body.Some of these complications are so dangerous that they make a substantial contribution to the con- siderable fatality due to this disease.Tables XXIV and XXV show the incidence of the main complications divided between 'first attack' cases and 'relapses', and further subdivided accord- ing to whether the complication occurred during the first referred attack or during the period of sub- sequent follow-up.'The right-hand column shows the overall incidence of these complications in our total series of 624 patients.This incidence must be regarded as an underestimate for two distinct reasons.First, in many cases we have had to rely purely on the case notes for our information, and some of the complications, especially minor ex- amples, may not have been recorded in all instances.Secondly, it can be seen from Tables XXIV and XXV that these complications are numerous during the course of follow-up and therefore some patients who have so far escaped complications are almost certain to have one or more in the future. LOCAL COMPLICATIONSISCHIO-RECTAL OR PARARECTAL ABSCESS Ischiorectal abscess is a common complication, about one in 25 of our whole series having had one so far.Such an abscess may form at any time, either in a first attack or in a relapse of long-established disease.Sometimes the abscess may appear when the colitis is clinically quiescent, although sigmoidoscopy will reveal that the rectum and lower colon are inflamed.An ischio-rectal abscess demands surgical drainage without delay.The abscess is often deep-seated so that formal surgery is required.It is one of the few 'The Tables are numbered consecutively in Parts I to IV inclusive.complications which are amenable to conservative surgery, leaving the colon intact.Illustrative case history Mr. W. L. was first seen at this hospital in 1955, when he presented in his first attack of ulcerative colitis, at the age of 34 years.There was evidence of disease affecting the bowel from the trans- verse colon onwards, but the attack was mild, and he responded well to treatment with local hydrocortisone.Three months later, after a recurrence of symptoms, he developed a very large ischio-rectal abscess.This was opened and drained without any complications, and he made a satisfactory recovery.Since then, there has been no recurrence of symptoms.