tbuckley/cabot-search huggingface dataset:
Lymphoproliferative disease in two sisters.
Authors: J V Garrett, R K Newton
Journal: BMJ (1979)

Serial serum HCG and AFP concentrations with details of combined modality treatment.Course A=vinblastine, bleomycin, methotrexate, and folinic acid.Course B= hydroxyurea, vincristine, methotrexate, folinic acid, cyclophosphamide, actinomycin D, adriamycin, and melphalan.Course C= vinblastine and bleomycin.Course D =vincristine, methotrexate, folinic acid, and cis-platinum.Course E=vincristine, methotrexate, folinic acid, and bleomycin.Course F-vincristine, actinomycin D
MD-Logic Overnight Control for 6 Weeks of Home Use in Patients With Type 1 Diabetes: Randomized Crossover Trial
Authors: Revital Nimri, Ido Muller, Eran Atlas, Shahar Miller, Aviel Fogel, Natasa Bratina, Olga Kordonouri, Tadej Battelino, Thomas Danne, Moshe Phillip
Journal: Diabetes Care (2014)

We evaluated the effect of the MD-Logic system on overnight glycemic control at patients' homes.Twenty-four patients (aged 12-43 years; average A1c 7.5 ± 0.8%, 58.1 ± 8.4 mmol/mol) were randomly assigned to participate in two overnight crossover periods, each including 6 weeks of consecutive nights: one under closed loop and the second under sensor-augmented pump (SAP) therapy at patients' homes in real-life conditions. The primary end point was time spent with sensor glucose levels below 70 mg/dL (3.9 mmol/L) overnight.Closed-loop nights significantly reduced time spent in hypoglycemia (P = 0.02) and increased the percentage of time spent in the target range of 70-140 mg/dL (P = 0.003) compared with nights when the SAP therapy was used. The time spent in substantial hyperglycemia above 240 mg/dL was reduced by a median of 52.2% (interquartile range [IQR] 4.8, 72.9%; P = 0.001) under closed-loop control compared with SAP therapy. Overnight total insulin doses were lower in the closed-loop nights compared with the SAP nights (P = 0.04). The average daytime glucose levels after closed-loop operation were reduced by a median of 10.0 mg/dL (IQR -2.7, 19.2; P = 0.017) while lower total insulin doses were used (P = 0.038). No severe adverse events occurred during closed-loop control; there was a single event of severe hypoglycemia during a control night.The long-term home use of automated overnight insulin delivery by the MD-Logic system was found to be a feasible, safe, and an effective tool to reduce nocturnal hypoglycemia and improve overnight glycemic control in subjects with type 1 diabetes.
Last Drill and Testament
Authors: Paula Tatarunis
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electronic patient‐reported outcome systems in oncology clinical practice
Authors: Antonia V. Bennett, Roxanne E. Jensen, Ethan Basch
Journal: CA A Cancer Journal for Clinicians (2012)

Patient-reported outcome (PRO) questionnaires assess topics a patient can report about his or her own health. This includes symptoms (eg, nausea, fatigue, diarrhea, pain, or frequent urination), physical functioning (eg, difficulty climbing stairs or difficulty fastening buttons), and mental health (eg, anxiety, fear, or worry). Electronic PRO (ePRO) systems are used in oncology clinical care because of 1) their ability to enhance clinical care by flagging important symptoms and saving clinicians time; 2) the availability of standardized methods for creating and implementing PROs in clinics; and 3) the existence of user-friendly platforms for patient self-reporting like tablet computers and automated telephone surveys. Many ePRO systems can provide actionable links to clinical care such as summary reports in a patient's electronic medical record and real-time e-mail alerts to providers when patients report acute needs. This review presents 5 examples of ePRO systems currently in use in oncology practice. These systems support multiple clinical activities, including assessment of symptoms and toxicities related to chemotherapy and radiation, postoperative surveillance, and symptom management during palliative care and hospice. Patient self-reporting is possible both at clinical visits and between visits over the Internet or by telephone. The implementation of an ePRO system requires significant resources and expertise, as well as user training. ePRO systems enable regular monitoring of patient symptoms, function, and needs, and can enhance the efficiency and quality of care as well as communication with patients.
Stathmin Overexpression Identifies High-Risk Patients and Lymph Node Metastasis in Endometrial Cancer
Authors: Jone Trovik, Elisabeth Wik, Ingunn M. Stefansson, Janusz Marcickiewicz, Solveig Tingulstad, Anne C. Staff, Tormund S. Njolstad, Ingrid Vandenput, Frederic Amant, Lars A. Akslen, Helga B. Salvesen
Journal: Clinical Cancer Research (2011)

Overexpression of the oncogen Stathmin has been linked to aggressive endometrial carcinoma and a potential for PI3Kinase inhibitors in this disease. We wanted to validate the prognostic value of Stathmin expression in a large prospective multicenter setting. As lymph node sampling is part of current surgical staging, we also aimed to test if Stathmin expression in endometrial curettage specimens could predict lymph node metastasis.A total of 1,076 endometrial cancer patients have been recruited from 10 centers to investigate the biological tumor marker Stathmin in relation to clinicopathologic variables, including lymph node status and survival. Stathmin immunohistochemical staining was carried out in 477 hysterectomy and 818 curettage specimens.Seventy-one percent of the patients (n = 763) were subjected to lymph node sampling, of which 12% had metastatic nodes (n = 94). Overexpression of Stathmin was detected in 37% (302 of 818) of the curettage and in 18% (84 of 477) of the hysterectomy specimens investigated. Stathmin overexpression in curettage and hysterectomy specimens were highly correlated and significantly associated with nonendometrioid histology, high grade, and aneuploidy. Stathmin analysis in preoperative curettage samples significantly correlated with, and was an independent predictor of, lymph node metastases. High Stathmin expression was associated with poor disease-specific survival (P ≤ 0.002) both in curettage and hysterectomy specimens.Stathmin immunohistochemical staining identifies endometrial carcinomas with lymph node metastases and poor survival. The value, as a predictive marker for response to PI3Kinase inhibition and as a tool to stratify patients for lymph node sampling in endometrial carcinomas, remains to be determined.
Companies in US pay up for silicone implants
Authors: J Roberts
Journal: BMJ (1994)

More than 25 000 lawsuits have forced three makers of silicone breast implants in the US to pay over $3bn (pounds sterling 2bn) towards a legal settlement fund that eventually will reach $4.75bn (pounds sterling 3.17bn). Since 1962 more than a million women in the US have been given breast implants, but the surgical procedure was banned in 1992 by the Food and Drug Administration FDA) after many women reported health problems. Medical …
Neurofibrosarcoma following radiotherapy for ankylosing spondylitis.
Authors: S J Bentley, P Davis, M I Jayson
Journal: Annals of the Rheumatic Diseases (1975)

Twenty-six years after radiotherapy to the spine for ankylosing spondylitis a patient developed a neurofibrosarcoma initially around the left sacroiliac joint. It is likely that this was a long-term complication of the radiotherapy.
Migration of 15 micron microspheres from infarcted myocardium
Authors: J. LEKVEN, K. S ANDERSEN
Journal: Cardiovascular Research (1980)

Journal Article Migration of 15 micron microspheres from infarcted myocardium Get access JON LEKVEN, JON LEKVEN * From the Surgical Research Laboratory, Haukeland Hospital, University of Bergen, Norway *Address for correspondence: Dr Jon Lekven, Surgical Research Laboratory, University of Bergen, Haukeland Hospital, N-5016 Bergen, Norway. Search for other works by this author on: Oxford Academic PubMed Google Scholar KNUT S ANDERSEN KNUT S ANDERSEN From the Surgical Research Laboratory, Haukeland Hospital, University of Bergen, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 14, Issue 5, May 1980, Pages 280–287, https://doi.org/10.1093/cvr/14.5.280 Published: 01 May 1980
Measurement of myocardial perfusion with positron emission tomography and generator-produced Copper-62-PTSM
Authors: Steven R. Bergmann, Carla J. Weinheimer, Pilar Herrero, Howard L. James, Marc E. Shelton, Joanne Markham, Carla J. Mathias, Mark A. Green, Michael J. Welch
Journal: Journal of the American College of Cardiology (1990)
Preclinical efficacy of MEK inhibition in Nras-mutant AML
Authors: Michael R. Burgess, Eugene Hwang, Ari J. Firestone, Tannie Huang, Jin Xu, Johannes Zuber, Natacha Bohin, Tiffany Wen, Scott C. Kogan, Kevin M. Haigis, Deepak Sampath, Scott Lowe, Kevin Shannon, Qing Li
Journal: Blood (2014)
Peripheral blood mononuclear cells of breast cancer patients can be reprogrammed to enhance anti-HER-2/neu reactivity and overcome myeloid-derived suppressor cells
Authors: Kyle K Payne, Christine K Zoon, Wen Wan, Khin Marlar, Rebecca C Keim, Mehrab Nasiri Kenari, Latif Kazim, Harry D Bear, Masoud H Manjili
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Barriers limiting the efficacy of adoptive cellular therapy (ACT) for breast cancer patients include immune suppression mediated by myeloid-derived suppressor cells (MDSC) and a low frequency of tumor-reactive memory T cells (Tm). Recently, we developed an ex vivo protocol to
Revolutionary Medical Journalism
Authors: Alfred Soffer
Journal: JAMA (1962)

<h3>To Sidney Shindell, M.D. (alias Benson):—</h3> After considerable thought, I venture to suggest these truths. As you know, there is a pattern in publishing house and scientific society press releases regarding new texts and journals. With a unanimity beyond dispute, sponsors of new publications suggest that their periodicals fulfill a unique need and are indispensable to the specialist or general practitioner. A journal of the type outlined by you and commended by many of us here can change this entire picture. Our effort would fulfill no need, perform no useful function, and, therefore, no problems or disputes could be created. The articles would not have to be read, meaning a considerable saving in time for the busy clinician or academician. Since no value could be attached to either the advertisements or the scientific content, most readers would soon suggest that the mailman leave their copies in the post office. This
Mousseau-Barbin tubes for benign strictures of the oesophagus
Authors: M. P. Holden, G. H. Wooler
Journal: Thorax (1971)

Two patients with benign strictures in the lower third of the oesophagus underwent insertion of Mousseau-Barbin tubes as palliative treatment for chronic dysphagia. The reasons for this particular form of treatment are discussed along with the unsatisfactory outcome.
Introductory Clerkships and the Community Hospital
Authors: Paul F. Griner
Journal: JAMA (1969)

As medical school-community hospital affiliations begin to flourish, it is likely that student assignments to the affiliate will be made at earlier stages of the curriculum. To this end, a number of prerequisites must be met in order to ensure a meaningful experience for the student. These include the definition of student goals and responsibilities; an informed and interested hospital administration and attending staff; proper communication of these aims to patients, house staff, and attending physicians; effective use of teaching talent (supplemented, when necessary, by the medical school); adequate student facilities; and resolution of logistic problems in the curriculum that tend to fragment the student's experience at the community facility. We have found some methods useful in resolving these difficulties.
The Disaster Preparedness Program: a new model for sustainable capacity building through civil-military collaboration
Authors: G Oravec, C Beadling
Journal: The Lancet Global Health (2015)

BackgroundThe Disaster Preparedness Program (DPP) is a partnership between The Center for Disaster and Humanitarian Assistance Medicine (CDHAM)—a part of the Uniformed Services University of the Health Sciences—and the United States Africa Command (USAFRICOM). The DPP aims to assist African partner nations to enhance their disaster preparedness and response capabilities. The programme takes a whole-of-government approach to disaster preparedness and response, with an emphasis on plan development and, in some cases, creation of an autonomous national disaster management agency.MethodsThe DPP worked with the Embassy and other US government stakeholders to identify key ministries involved in disaster preparedness. With DPP assistance, a technical team from the partner nation undertook a comprehensive assessment of their current disaster response capabilities. This information was used to construct a disaster management strategic work plan that identified specific gaps in disaster preparedness. A disaster simulation exercise was conducted with representatives from agencies and ministries involved in disaster response. They applied their existing structure, plans and resources to a scenario designed for their country by CDHAM in order to identify any additional shortfalls in the plan. The finalised work plan could then be used by the partner nation to prioritise and address immediate needs.FindingsSince 2009, CDHAM has worked with 16 partner nations. Ten countries have developed national pandemic influenza preparedness and response plans. By December, 2014, one country had used this plan to prevent the spread of Ebola, one country adapted this plan to a whole-of-government Ebola response, and six others are currently in the process of adopting this approach. Eight African armies have drafted "military support to civil authorities" disaster contingency plans, and one army has used this approach with Ebola. Ten countries have developed disaster management strategic work plans and are currently conducting activities in partnership with the US State Partnership Program, USAFRICOM, the Defense Threat Reduction Agency and the World Bank to fill gaps in their national disaster preparedness.InterpretationAlthough the work with the DPP is expected to enhance partner nations' preparedness and response to disasters, measuring the outcomes of these projects may take several years. The next phase of the DPP will focus on sustained support to local programmes while working with them to assess improvements in their response capabilities. As a result of these successful partnerships, CDHAM is now also playing a major role in assisting west African partner nations with Ebola preparedness activities.FundingInitially provided through USAID, but funding is now provided through the Defense Security Cooperation Agency's Overseas Humanitarian, Disaster, and Civic Aid.
CXCL13 Is Highly Produced by Sézary Cells and Enhances Their Migratory Ability via a Synergistic Mechanism Involving CCL19 and CCL21 Chemokines
Authors: Maria Cristina Picchio, Enrico Scala, Debora Pomponi, Elisabetta Caprini, Marina Frontani, Irene Angelucci, Antonella Mangoni, Cristina Lazzeri, Marie Perez, Daniele Remotti, Emanuela Bonoldi, Roberto Benucci, Giannandrea Baliva, Giuseppe Alfonso Lombardo, Monica Napolitano, Giandomenico Russo, Maria Grazia Narducci
Journal: Cancer Research (2008)

Abstract Chemokine and chemokine receptors expressed by normal and neoplastic lymphocytes play a key role in cell recruitment into skin and lymph nodes. The aim of this study was to get further insights into the role of chemokines in pathogenesis and progression of cutaneous T-cell lymphoma (CTCL) with particular regard to Sézary Syndrome (SS), a CTCL variant with blood involvement. Here, we show that functional CXCL13 homeostatic chemokine is strongly up-regulated in SS cells, well-detectable in skin lesions and lymph nodes, and measurable at high concentration in plasma of SS patients, at different levels during disease progression. Furthermore, we show that the addition of CXCL13 to CCL19 or to CCL21, the selective CCR7 agonists responsible for lymph node homing, strongly enhances the migration of CCR7+ SS cells. We also show that neutralization of the CCR7 receptor strongly impairs CCL19/21-induced chemotaxis of SS cells both in the absence or presence of CXCL13. Additional experiments performed to investigate the survival, adhesion, and metalloproteases secretion indicate that CXCL13 combined with CCL19 and CCL21 mainly affects the chemotaxis of SS cells. Our findings suggest that this newly described CXCL13 expression in SS represents a new pathogenetic mechanism of diagnostic significance. [Cancer Res 2008;68(17):7137–46]
Turning a blind eye:Why we don't test for blindness at the end of our trials
Authors: David L Sackett
Journal: BMJ (2004)

EDITOR—I write with reference to the paper by Fergusson et al.1 Asking patients or their clinicians at the end of a trial which drug they think they were taking confounds failures in blinding with successes in pre-trial hunches about efficacy.

Thirty years ago, at the end of the first ever trial of aspirin and sulfinpyrazone …
Subdural Haematoma and Effusion in Infancy
Authors: K. Till
Journal: BMJ (1968)

Analysis of 116 cases of subdural haematoma and effusion in infancy showed that in 40% trauma was involved and in 5% meningitis was an aetiological factor; in the remainder there was no known antecedent disease. Apart from retinal or subhyaloid haemorrhages there were no clinical features pathognomonic of the condition, though vomiting was the commonest presenting symptom and a tense fontanelle the commonest finding on examination. Treatment by subdural pleural shunt operation, which allows the fluid to drain into the chest, where it is absorbed, was found to be effective, and there is no longer any justification for the older method of removal of the subdural membrane by craniotomy.
Depth of Submucosal Invasion Does Not Predict Lymph Node Metastasis and Survival of Patients With Esophageal Carcinoma
Authors: Rami J. Badreddine, Ganapathy A. Prasad, Jason T. Lewis, Lori S. Lutzke, Lynn S. Borkenhagen, Kelly T. Dunagan, Kenneth K. Wang
Journal: Clinical Gastroenterology and Hepatology (2009)
Congenital Toxoplasmosis in Southeastern Brazil: Results of Early Ophthalmologic Examination of a Large Cohort of Neonates
Authors: Daniel Vitor Vasconcelos-Santos, Danuza O. Machado Azevedo, Wesley R. Campos, Fernando Oréfice, Gláucia M. Queiroz-Andrade, Éricka V. Machado Carellos, Roberta M. Castro Romanelli, José Nelio Januário, Luciana Macedo Resende, Olindo Assis Martins-Filho
Journal: Ophthalmology (2009)
STUDIES ON THE CONSERVATION OF EPIDERMAL SPECIFICITIES OF SKIN AND CERTAIN MUCOSAS IN ADULT MAMMALS
Authors: R. E. Billingham, Willys K. Silvers
Journal: The Journal of Experimental Medicine (1967)

To determine whether the factor(s) responsible for the conservation of epidermal specificities in adult guinea pigs and hamsters resides in the germinal layer of the epidermis or in the dermis, thin grafts of skin, possessing qualitatively distinct regional characteristics, were separated into their superficial epidermal and dermal components with the aid of trypsin. Dermis of one type was combined with epidermis of another to produce "recombinant" grafts which were then transplanted to small, full thickness cutaneous sites on the thorax of geneticaily compatible hosts. A variant of this procedure involved transplanting sheets of superficial epidermis of various types to shallow split thickness recipient areas in the skin of the thorax. All grafts were maintained for 100 days before they were excised and examined histologically. The results indicate that, whereas the dermis determines the kind of epidermis produced in recombinant grafts involving the ear, the sole of the foot, and the trunk, this is not the case in recombinants which include tongue, esophageal, or cheek pouch epithelia. The one exception to this occurred when tongue or esophagus epithelia were transplanted to split thickness beds in trunk skin. Here they appeared to produce an epidermis characteristic of their new location. It is believed that this exception is probably due to the fact that the native follicular epidermis present in trunk dermis made such a substantial contribution to the new superficial epidermis that it behaved overtly as body skin epidermis. Taken together, these results suggest that basal layer cells of the superficial epidermis of sole of foot skin, ear skin, and the hair-bearing skin of the general integument behave as if they are equipotential, and that in adult life maintenance of these particular epidermal specificities is the outcome of persistent specific inductive stimuli from the underlying dermis. The results of subsidiary experiments are reported which indicate that the epithelial component of mammary gland tissue is also pluripotential, being capable of producing, under appropriate conditions, a normal-looking, fully stratified superficial epidermis.