tbuckley/cabot-search huggingface dataset:
P7 Occupational eosinophilic constrictive bronchiolitis with asthma in a foam cutter caused by Soya bean products
Authors: J. Hoyle, K. Ballance, H. Francis, C. Pickering, R. Niven
Journal: Thorax (2010)

<h3>Introduction and background</h3> Soya bean dust is a recognised cause of asthma. More recently Soya bean has bean used in the manufacture of foam. The main market for this ‘environmentally friendly foam’ is for cot mattresses. We describe a case of occupational asthma with eosinophilic constrictive bronchioloitis caused by cutting foam manufactured using Soya bean. This is the first case in world literature to the authors′ knowledge where Soya bean induced respiratory allergy has been described in this way. <h3>Case description</h3> 26-year male smoker presents with a 3-month history of fatigue, 10 kg weight loss, cough and work related breathlessness. Soya-based foam had been introduced into the work place 6 months prior to presentation, which the subject cut with a band knife. No respiratory protection or ventilation was used. No previous allergies or asthma were known. Throat itch preceded symptom onset. Other workers complained of conjunctivitis. At presentation the subject was apyrexial, oxygen sats 88% air, CRP 0.7, peripheral eosinophils 1.6 (14%), WBC normal and FEV1 34% predicted. Vasculitis and HIV screening negative. HRCT confirmed constrictive bronchiolitis, which resolved after a course of oral steroids. Lung function returned to normal. The subject was re-introduced to work where a marked drop in FEV1 was documented (Abstract P7 Figure 1). Bronchoscopy showed mucus plugging with eosinophilic casts. Peripheral eosinophilia increased with general fatigue. Total IgE remained normal, IgE for <i>Aspergillus fumigatus</i> &lt;0.4. IgE for soya was 0.4, but slightly elevated for other cross reactants. Skin tests for Soya bean and husk were positive. The worker was redeployed away from the foam cutting area but still had occasional exposure and peak flow variability compatible with occupational asthma, with increased non-specific bronchial hyper-reactivity on histamine challenge. Lung function, eosinophil count and bronchial reactivity stabilised following removal of the foam from the factory and home. <h3>Conclusion</h3> Eosinophilic airway plugging, with severe air trapping, reversible airflow obstruction and peripheral eosinophilia resolved after removing Soya bean based foam products from the work area and home. Skin prick tests confirm Soya bean allergy. The syndrome described has not been reported previously and may have implications for the foam manufacturing industry.
Double Cardiac Arrest with Survival
Authors: B. L. Finer, B. O. Nylen
Journal: BMJ (1959)

tessalon.A severe headache also occurred in a patient given intravenous therapy.Naegeli (1956) has also found this symptom in patients treated with tessalon.We are unable to confirm the antitussive action of tessalon that has been reported (Giuliano and Rossa, 1955; Bucher, 1956, Herzog, 1956; Naegeli, 1956; Neumann, 1956; Simon, 1957; Shane et al., 1957).One patient noticed considerable relief from coughing while taking both the placebo and the drug, and another lost the desire to cough after intravenous administration of tessalon.All our patients, however, had a severe grade of dyspnoea with a relatively minor degree of cough. SummaryTessalon-a polyethylene glycol derivative of p-amino- benzoic acid-has been given intravenously in doses up to 45 mg.without causing symptoms or having any measurable effect on minute-volume, air flow, intrathoracic pressure, maximum breathing capacity, respiratory rate, pulse rate, and blood pressure in four normal subjects and 10 patients with chronic lung disease.A double-blind trial of tessalon in 23 patients with chronic pulmonary disease did not have any beneficial effect.We thank Dr.
Changes in Plasma Renin Activity Produced by Infusions of Dextran and Dextrose
Authors: P. T. Pickens, B. A. Enoch
Journal: Cardiovascular Research (1968)

The hypothesis that changes in plasma volume determine renin secretion has been tested by measurement, in normal human subjects, of plasma renin activity after intravenous infusion of dextran, after intravenous infusion of dextrose, and after oral administration of a thiazide diuretic. In these experiments a fall in haematocrit was accompanied by a fall in plasma renin activity and a rise in haematocrit by a rise in plasma renin activity.
Increased doses of clopidogrel or aspirin did not prevent cardiovascular events
Authors: David J. Moliterno
Journal: Annals of Internal Medicine (2011)

ACP Journal Club18 January 2011Increased doses of clopidogrel or aspirin did not prevent cardiovascular eventsDavid J. Moliterno, MDDavid J. Moliterno, MDUniversity of Kentucky, Lexington, Kentucky, USA (D.J.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-2-201101180-02007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationCURRENT-OASIS 7 Investigators, Mehta SR, Bassand JP, et al. Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. N Engl J Med. 2010;363:930-42. https://pubmed.ncbi.nlm.nih.gov/20818903Clinical Impact RatingsEmergency Med: Hospitalists: Cardiology: References1 King SB, Smith SC Jr, Hirshfeld JW Jr, et al. 2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice guidelines. J Am Coll Cardiol. 2008;51:172-209. [PMID: 18191745] Google Scholar2 Mehta S. The CURRENT OASIS 7 trial. Data presented at Hotline Session of the ESC Congress. 30 August 2009; Barcelona, Spain. Google Scholar3 Mehta SR, Tanguay JF, Eikelboom JW, et al. Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet. 2010;376:1233-43. [PMID: 20817281] Google Scholar4 von Beckerath N, Kastrati A, Wieczorek A, et al. A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days. Eur Heart J. 2007;28:1814-9. [PMID: 17272357] Google Scholar5 Price M. Standard versus high-dose clopidogrel according to platelet function testing after PCI: Results of the GRAVITAS Trial. American Heart Association Scientific Sessions Late-Breaking Clinical Trials, Chicago, Ill; 16 Nov 2010. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Kentucky, Lexington, Kentucky, USA (D.J.M.)This article was published at Annals.org on 4 January 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 January 2011Volume 154, Issue 2Page: JC1-7KeywordsAngiographyHemorrhageIschemiaMyocardial infarctionPercutaneous coronary interventionStrokeSurgery ePublished: 18 January 2011 Issue Published: 18 January 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Postprandial lipoprotein (a) response to a single meal containing either saturated or ω-3 polyunsaturated fatty acids in subjects with hypoalphalipoproteinemia
Authors: Angelo M. Scanu, Celina Edelstein, Gunther M. Fless, James Eisenbart, Michael Sitrin, Bahaa Kasawa, Janet Hinman
Journal: Metabolism (1992)
General practice and the care of children with HIV infection: 6 month prospective interview study
Authors: M. Boulton, E. Beck, S. Walters, D. Miller
Journal: BMJ (1999)

<h3>Abstract</h3> <b>Objectives:</b> To describe the use of primary care services by children infected with HIV and to explore the attitudes of their parents to the role of general practitioners in their children9s care. <b>Design:</b> A 6 month prospective study. Quantitative analysis of “contact diaries” kept by parents; qualitative analysis of face to face interviews with parents. <b>Participants:</b> Parents of children receiving care at a regional referral centre in London. <b>Results:</b> Twenty four families (80% response rate) were recruited to the study. In 19 families the mother was black African. Half the children had been diagnosed with symptomatic HIV infection, half with AIDS. All the children were registered with a general practitioner who knew of the child9s HIV infection. In five families there had initially been tensions in their relationship with their general practitioner but by the time of the study all but one family had established at least an “acceptable” relationship. Children with symptomatic HIV infection saw their general practitioner a mean of 7.5 times per patient year; for children with AIDS the figure was 5.8. Parents regarded the paediatric HIV team at the hospital as their primary source of medical care. Three factors constrained their use of general practice: their own anxieties about distinguishing “normal” symptoms from those related to HIV infection; their view that their general practitioner did not feel competent to treat HIV infected children; and their concerns about maintaining confidentiality in the surgery. <b>Conclusions:</b> Parents remain oriented towards the paediatric HIV team as their primary source of medical care and use general practice largely for routine prescriptions for their children. Any further development of the general practitioner9s role will need to build on existing relationships with specialist providers and take account of parents9 concerns. <h3>Key messages</h3> With appropriate help from the paediatric HIV team when necessary, all parents were willing to register with a local general practitioner and to disclose their child9s HIV infection Parents remained oriented towards the specialist paediatric HIV team as their main source of medical care and looked to the general practitioner largely for routine prescriptions Parents preferred to go directly to the paediatric HIV team when their child developed new symptoms because of their own uncertainty about how to distinguish between “normal” childhood symptoms and those related to HIV infection Parents were reluctant to consult their general practitioner because they observed that he or she did not feel competent to treat HIV infected children and because they were concerned about the difficulties of maintaining confidentiality in a busy surgery
Diabetic Diarrhea and Clonidine
Authors: Alberto Migliore
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 July 1988Diabetic Diarrhea and ClonidineAlberto Migliore, MD, Carlo Barone, MD, Raffaele Manna, MD, Aldo Virgilio Greco, MDAlberto Migliore, MD, Carlo Barone, MD, Raffaele Manna, MD, Aldo Virgilio Greco, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-2-170_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Fedorak and associates (1) have proposed the use of Clonidine, a specific alpha-2-adrenergic receptor agonist, for treating diabetic diarrhea. Diabetic diarrhea, a severe complication of long-term and poorly controlled disease, is often associated with autonomic and peripheral neuropathy. Experimental data have suggested that the loss of adrenergic innervation may play a role in impaired intestinal fluid and electrolyte absorption in diabetic patients with autonomic neuropathy (2). Stimulation of alpha-2-adrenergic receptors on enterocytes can reverse malabsorption and inhibit anion secretion.A 22-year-old man with poorly controlled insulin-dependent diabetes mellitus for 7 years had watery diarrhea (seven to eight...References1. Fedorak N, Field M, and Chang E. Treatment of diabetic diarrhea with Clonidine. Ann Intern Med. 1985;102:197-9. LinkGoogle Scholar2. Chang E, Bergenstal R, and Field M. Diabetic diarrhea: loss of adrenergic regulation of intestinal fluid and electrolyte transport. Gastroenterology. 1983;84:1121. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Alberto Migliore, MD; Carlo Barone, MD; Raffaele Manna, MD; Aldo Virgilio Greco, MDAffiliations: Catholic University Rome, Italy 00168 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTreatmentWhat about clonidine for diarrhoea? A systematic review and meta-analysis of its effect in humansDiarrheaThe Effect of Clonidine on Gastrointestinal Side Effects Associated with Ultra-Rapid Opioid DetoxificationDIABETES AND THE GASTROINTESTINAL TRACTLong-Term Complications of Diabetes Mellitus, Part II: Gastrointestinal and Infectiousα-AdrenoceptorsDiabetic diarrhea 15 July 1988Volume 109, Issue 2Page: 170-171KeywordsAnionsDiabetes mellitusDiarrheaDysenteryInsulinNeuropathyPeripheral neuropathy ePublished: 1 December 2008 Issue Published: 15 July 1988 PDF downloadLoading ...
Mechanisms regulating the renal excretion of sodium during pregnancy
Authors: Charles A. Robb, James O. Davis, J. Alan Johnson, Edward H. Blaine, Edward G. Schneider, John S. Baumber
Journal: Journal of Clinical Investigation (1970)

Observations were made on the relation of the renin-angiotensin-aldosterone system and renal hemodynamic function to sodium balance in 43 pregnant dogs. Daily balance studies revealed that about 30-40% of ingested sodium was retained during the last half of pregnancy; during the same period, potassium balance was also positive but to a lesser extent. For groups of pregnant dogs, plasma renin activity (n = 14) and aldosterone secretion (n = 19) were significantly higher than normal; however, in some animals one or both functions were normal even though sodium retention was present. In contrast, plasma renin substrate concentration was consistently elevated during pregnancy in seven dogs. In a group of nine dogs in which both aldosterone secretion and plasma renin activity were measured, aldosterone secretion was elevated in the three dogs with the highest values for plasma renin activity; in two of the remaining six animals aldosterone secretion was elevated but plasma renin activity was normal or only slightly increased. The sequestration of sodium and water into the uterine contents was defined quantitatively in this study but evidence was lacking to support the idea that such changes led to renin release. The glomerular filtration rate (GFR) was significantly elevated throughout pregnancy but a significant decrease from the high level of mid-pregnancy occurred during the last half of pregnancy; this decrease in GFR probably contributed to the sodium retention. Administration of a large dose of deoxycorticosterone acetate (DOCA) to dogs in late pregnancy produced marked sodium retention but "escape" from the sodium-retaining steroid occurred. The data demonstrate that although increased activity of the renin-angiotensin-aldosterone system was frequently present during pregnancy, a normal rate of aldosterone secretion occurred. This finding and the observed "escape" from DOCA suggest the existence of sodium-retaining mechanisms other than the mechanism provided by a high plasma level of aldosterone.
An urgent fax
Authors: R. Chaplin
Journal: BMJ (2001)

Recently, four faxes arrived in my office within 24 hours asking for urgent psychiatric community assessments. They all told separate stories of human misery and asked for emergency psychiatric consultations. It was clearly impossible to see all the patients immediately as I was the only senior psychiatrist covering the team. I therefore tried to call the referring doctors in order to prioritise the patients but could locate only one.

A fax is easy to send. Firstly, you dictate a letter (an …
Blood Radiation Dose After 131I Therapy of Thyrotoxicosis
Authors: M. Green, M. Fisher, H. Miller, G. M. Wilson
Journal: BMJ (1961)

A case of acute leukemia diagnosed 17 months after I/sup 131/ therapy for thyrotoxicosis is reported. In an attempt to assess the relationship between I/sup 131/ therapy and the subsequent developmeni of leukemia the radiation dose to the blood after a single therapeutic dose of I/sup 131/ was measured in l9l thyrotoxic patients. The mean irradiation to the blood was 8 rads per therapeutic dose. The irradiation dose to the blood is related to the amount of l/sup 131/ administered and the fraction passing into the plasma as proteinbound I/sup 131/. A nomogram taking into account these two factors was constructed from the measurements made on the 191 patients, so that the irradiation dose to the blood can be estimated in other patients treated by I/sup 131/ for thyrotoxicosis. The blood irradiation dose for complete treatment of the disease was estimated from the nomogram in 802 patients previously treated with I/sup 131/ . The mean dose was l6.6 rads, but in some patients receiving multiple treatments it was much greater, ranging up to 160 rads. The bone-marrow dose is estimated as 80% of the blood dose. Consideration of these results suggests that the risk of leukemogenesis is slight and doesmore » not contraindicate I/sup 131/ therapy of thyrotoxicosis. Nevertheless it is important to record all cases of leukemia occurring after I/sup 131/ therapy so that the validity of these conclusions may be examined. (auth)« less
Lack of Cyclophilin B in Osteogenesis Imperfecta with Normal Collagen Folding
Authors: Aileen M. Barnes, Erin M. Carter, Wayne A. Cabral, MaryAnn Weis, Weizhong Chang, Elena Makareeva, Sergey Leikin, Charles N. Rotimi, David R. Eyre, Cathleen L. Raggio, Joan C. Marini
Journal: New England Journal of Medicine (2010)

Osteogenesis imperfecta is a heritable disorder that causes bone fragility. Mutations in type I collagen result in autosomal dominant osteogenesis imperfecta, whereas mutations in either of two components of the collagen prolyl 3-hydroxylation complex (cartilage-associated protein [CRTAP] and prolyl 3-hydroxylase 1 [P3H1]) cause autosomal recessive osteogenesis imperfecta with rhizomelia (shortening of proximal segments of upper and lower limbs) and delayed collagen folding. We identified two siblings who had recessive osteogenesis imperfecta without rhizomelia. They had a homozygous start-codon mutation in the peptidyl-prolyl isomerase B gene (PPIB), which results in a lack of cyclophilin B (CyPB), the third component of the complex. The proband's collagen had normal collagen folding and normal prolyl 3-hydroxylation, suggesting that CyPB is not the exclusive peptidyl-prolyl cis-trans isomerase that catalyzes the rate-limiting step in collagen folding, as is currently thought.
Why people stay healthy
Authors: F. Eskin
Journal: BMJ (1997)

Introducing the postoperative care team Effective postoperative care remains surgeons' roleEditor-I am concerned that the suggestions made by David R Goldhill might be taken too seriously rather than remain a point for discussion. 1 Goldhill is right in his assertion that patients can fare badly in their postoperative course because of lack of attention by their attendants and lack of understanding of common postoperative complications.I believe, however, that he has missed the opportunity to lay the blame at the correct door.Surely it is the surgeons' role to carry out preoperative assessment, surgery, and effective postoperative care.If they choose to emphasise their importance in the operating theatre, delegating their other responsibilities to their trainees, the nurse practitioners, and the anaesthetists, why should we encourage this path?Undoubtedly, anaesthetists are fast becoming the new generalists, with an increasing role outside the operating theatre.These new skills and responsibilities include pain control, intensive care, and transoesophageal echocardiography, to name but a few.Some of my professional colleagues may relish even more diversification and abhor my comments.Goldhill implies that anaesthetists and postoperative care nurses will lead the postoperative care team; indeed, this is already happening in North America, where they have been sent to run preoperative assessment clinics by surgeons based in the operating room.If the surgical ward round in your hospital has become a quick look through the laboratory results and a glance at the chest radiograph before a rush to the changing rooms then I suggest that waiting for the confidential inquiry into perioperative deaths to point out the obvious is not the solution.
Who gets Creutzfeldt-Jakob disease?
Authors: R M Ridley, H F Baker
Journal: BMJ (1995)

Whenever an unusual case of Creutzfeldt-Jakob disease is reported in Britain someone asks: “Is this the beginning of the end--are we all going to die of BSE?” It is a commonly held view that the incubation period for spongiform encephalopathy in humans is at least one to two decades. This is a misconception. For kuru, when the dose of infectivity by the oral route was high the minimum incubation period was less than four years and the median ranged from less than five years to nine years (judged by the minimum ages at onset at the height of the epidemic).1However, the incubation period can be as long as 30 years (judged by the ages of the most recent cases).2

While experimental transmission …
Prostaglandin F2 alpha enhancement of capsaicin induced cough in man: modulation by beta 2 adrenergic and anticholinergic drugs.
Authors: G Nichol, A Nix, P J Barnes, K F Chung
Journal: Thorax (1990)

The effect of inhaled prostaglandin (PG) F2 alpha on the response to the inhaled tussive agent capsaicin was investigated in normal subjects. Seven subjects inhaled three breaths of four doses of capsaicin (0.3, 0.6, 1.2, and 2.4 nmol) before and immediately after inhaling PGF2 alpha (0.1 mumol) or placebo (0.15M NaCl) on separate days. The numbers of capsaicin induced coughs were greater after PGF2 alpha (mean 42.3 coughs) than after 0.15M sodium chloride (30.1). Visual analogue scores (0-10 on a 10 cm continuous scale) showed that capsaicin was more irritant after PGF2 alpha than after saline. Total respiratory resistance (Rrs), measured by the forced oscillation technique, was unaltered throughout the study. A double blind, placebo controlled study of the effects of inhaled salbutamol (200 micrograms, 0.6 mumol) and ipratropium bromide (40 micrograms, 0.1 mumol) on cough induced by capsaicin (2.4 nmol) and by PGF2 alpha (0.1 mumol) and on PGF2 alpha augmented, capsaicin induced coughing was performed in seven subjects. Neither drug had any effect on capsaicin induced coughing. Salbutamol reduced coughing due to PGF2 alpha (mean 7.7 coughs after salbutamol, 9.3 after placebo) but ipratropium bromide did not (mean 6.9 coughs after ipratropium bromide, 6.6 after placebo). Salbutamol also inhibited the augmentation of the capsaicin induced cough that followed inhalation of PGF2 alpha (mean augmentation 1.9 coughs after salbutamol, 4.1 after placebo), whereas ipratropium bromide did not (augmentation 1.7 coughs after ipratropium bromide, 2.7 after placebo). No changes in Rrs were seen after PGF2 alpha or either drug. Thus salbutamol reduces PGF2 alpha induced cough and the augmentation of capsaicin induced cough that follows PGF2 alpha.
Differential regulation of actin stress fiber assembly and proplatelet formation by α2β1 integrin and GPVI in human megakaryocytes
Authors: Siham Sabri, Martine Jandrot-Perrus, Jacques Bertoglio, Richard W. Farndale, Véronique Mansat-De Mas, Najet Debili, William Vainchenker
Journal: Blood (2004)
Experimental Validation of Circumferential, Longitudinal, and Radial 2-Dimensional Strain During Dobutamine Stress Echocardiography in Ischemic Conditions
Authors: Patricia Reant, Louis Labrousse, Stephane Lafitte, Pierre Bordachar, Xavier Pillois, Liliane Tariosse, Simone Bonoron-Adele, Philippe Padois, Claude Deville, Raymond Roudaut, Pierre Dos Santos
Journal: Journal of the American College of Cardiology (2008)
Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis
Authors: Rajkumar Noubade, Dimitry N. Krementsov, Roxana del Rio, Tina Thornton, Viswas Nagaleekar, Naresha Saligrama, Anthony Spitzack, Karen Spach, Guadalupe Sabio, Roger J. Davis, Mercedes Rincon, Cory Teuscher
Journal: Blood (2011)