tbuckley/cabot-search huggingface dataset:
"Medication concordance" is best helped by improving consultation skills
Authors: J. Chen
Journal: BMJ (1999)

E—“Medication concordance” is a term used to signify that the doctor and patient have come to a shared agreement about therapeutic goals.1 It is merely one end point; to have reached it the doctor would have had to develop a rapport with the patient, understood the illness in his or her terms, come to a shared understanding and agreement about the diagnosis, and imparted information about the proposed treatment and given alternative choices. The doctor should provide the patient with alternative professionals for …
The Safety of Medicines: Evaluation and Prediction
Authors: Robert C. Hastings
Journal: JAMA (1981)

Professor Folb is professor of pharmacology at the University of Cape Town and chief physician at Groote Schuur Hospital in Cape Town, South Africa, with research interests in mechanisms and animal models of drug toxicities. From this authoritative perspective the author has prepared a series of six informative essays describing and commenting on, in layman's language, the subject of drug safety. The underlying theme of the work is that no drug is completely safe and that everyday therapeutics always involves a risk-benefit assessment in clinical practice. The overriding principle in the development of new drugs should be reasonableness rather than wasteful overregulation (and disincentives to drug developers) in an attempt to assure the impossible: a completely safe medication. General principles of drug safety are defined in terms of preclinical animal studies and their extrapolation into early clinical trials of new drugs; these include teratogenic potential, drug dependence, carcinogenic potential, potential
The Myth of the Abortion Trauma Syndrome Revisited-Reply
Authors: Nada L. Stotland
Journal: JAMA (1993)

In Reply.  —The personal feelings of Drs Bishop, Josephson, Belding, and Dowling are telling, but their arguments are not. As for feelings, I personally share their dismay about abortion. I deplore the circumstances that all too often make women feel that abortion is their only real option. Like Dr Blake, my feelings focus on the physical and emotional health of women and their families, people who have already been born. I do not lack feelings for the conceptus, but I have stronger feelings about unwanted children, blighted lives, and the morbidity and mortality of illegal abortions.  However, scientific medicine is based on evidence, not feelings. The burden of proof for the designation of a disease lies on its proponents. Dr Koop, who was an outspoken opponent of abortion when selected as US Surgeon General, understood and observed this rule. No doubt some women are unhappy and some become or continue
Community-Oriented Primary Care-Reply
Authors: David E. Rogers
Journal: JAMA (1983)

<h3>In Reply.—</h3> I find Dr Robert Gillette's letter right on target in virtually all respects. Most important is his concern that preoccupation with high-technology treatment will tend to push out the less esoteric and less dramatic demands required for an effective physician to do his proper job in a community setting. I also thoroughly agree that primary care careers require that physicians be comfortable in dealing with ambiguity and human support systems, rather than simply treating well-differentiated disease per se. I would differ only with his view that today there are too many different kinds of "providers." All of the data suggest that we will never have enough of one kind of provider to do the primary or general-care job as adequately as we might wish. Thus, while I applaud the person- and family-oriented focus of family practitioners, it is my own view that all general physicians in front-line practices
Hemodynamic Effects of Orally Administered Isosorbide Dinitrate in Patients with Congestive Heart Failure
Authors: JOSEPH A. FRANCIOSA, ESTEBAN MIKULIC, JAY N. COHN, ERNESTO JOSE, ANASTACIA FABIE
Journal: Circulation (1974)

The efficacy of orally administered isosorbide dinitrate (IS) has been questioned. Recently vasodilators have been shown to lower left ventricular filling pressure (LVFP) and raise cardiac output in heart failure. In the present study oral IS was evaluated in 12 patients with high LVFP due to heart failure. After right heart catheterization, patients with LVFP &gt; 14 mm Hg were randomized double-blind to receive either 20 mg IS or placebo (P). Supine heart rate (HR), arterial pressure (BP), and LVFP were monitored for five hours. After this the alternate drug (P or IS) was given, followed by five more hours of monitoring. In the 12 patients after receiving IS, LVFP reached a peak reduction of 6.7 mm Hg (-26%, P &lt; 0.005) at 30 min. Significant reduction persisted for 4.5 hours. Blood pressure fell concomitantly with the LVFP. At 60 min HR was unchanged, systolic BP was reduced by 8.9 mm Hg (P &lt; 0.025) and diastolic BP by 6.3 mm Hg ( P &lt; 0.005). In the ten patients receiving P, control values were not significantly different from those given IS, and after receiving P, HR, BP, and LVFP failed to change significantly over the next five hours. Thus, oral IS produces a sustained reduction in LVFP and therefore merits further evaluation as chronic therapy for left ventricular failure.
THE GROWTH OF ADULT HUMAN SKIN IN VITRO
Authors: M. LEVINE
Journal: British Journal of Dermatology (1972)

Summary.— In this report we investigate the role of serum in organ culture of adult human skin. The migratory overgrowth of dermis by epidermal cells is shown to depend on the presence of high molecular weight (mol. wt.) components of serum. Regeneration of the epidermis after 19 days' incubation occurs in the presence of 10% whole serum in the growth medium. DNA synthesis is found to increase in long‐term incubations in medium including serum components but not in the presence of Minimal Essential Medium (MEM) only.
Direct-to-Consumer Advertising With Added Inducements
Authors: Marilyn C. Kincaid
Journal: JAMA (1992)

ABSTRACT To the Editor. —Recently, I saw an advertisement (Parade. August 11, 1991: 13-14) for the medication Tenormin (atenolol, ICI Pharma, Wilmington, Del) that was directed at patients. This full-color advertisement covered two pages and included a number of free and discounted goods and services that a Tenormin patient was eligible to receive. Some of the samples made sense for patients taking a cardioselective β-blocker, such as the low-fat recipes and the decaffeinated coffee. However, other goods such as Polaroid film and compact disks, of less obvious specific benefit to a patient on a prescription drug, were also featured.I have visions of patients coming to a physician's office demanding to be given a specific brand of medication so that they would be eligible to receive these product offers. That certainly appears to be the purpose of this ad, directed as it was to patients reading the Sunday magazine section of
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group
Authors: Libi Hertzberg, Elena Vendramini, Ithamar Ganmore, Gianni Cazzaniga, Maike Schmitz, Jane Chalker, Ruth Shiloh, Ilaria Iacobucci, Chen Shochat, Sharon Zeligson, Gunnar Cario, Martin Stanulla, Sabine Strehl, Lisa J. Russell, Christine J. Harrison, Beat Bornhauser, Akinori Yoda, Gideon Rechavi, Dani Bercovich, Arndt Borkhardt, Helena Kempski, Geertruy te Kronnie, Jean-Pierre Bourquin, Eytan Domany, Shai Izraeli
Journal: Blood (2009)
How is Cancer Treatment Chosen?
Authors: Robert J. Mayer, W. Bradford Patterson
Journal: New England Journal of Medicine (1988)

Multiple factors contribute to the process of deciding on a choice of treatment for the patient with cancer. Some of these factors, such as the histologic diagnosis, stage of disease, functional status, and pattern of metastatic spread, are attributes of the tumor and are fairly objective in nature. They represent the cornerstones on which both treatment recommendations and assessments of the efficacy of treatment have been based. Other factors are only indirectly related to the tumor and include the biases of the patient or physician with respect to various types of therapy, as well as the patient's age, degree of . . .
Diabetic Foot Ulcer: Amputation on Request?
Authors: Andrew Collier, Al Dowie, Sujoy Ghosh, Peter C. Brown, Iqbal Malik, Steven Boom
Journal: Diabetes Care (2011)

In 2000, a Scottish surgeon received significant publicity for amputating lower limbs from healthy patients who were thought to have a Body Integrity Identity Disorder (1). We present a type 1 diabetic patient with a recurrent foot ulcer who requested a lower-limb amputation. Although very different, this situation also created difficult ethical issues that we have attempted to address.

Peter C. Brown (aged 54 years) was diagnosed as having type 1 diabetes at age 21 years. Between early 2006 and November 2008, he had several admissions with a diabetic foot ulcer that partly resolved but never fully healed (2). By early November 2008 and after discussions with his family, he decided that he …
Cytotoxicity of silica nanoparticles through exocytosis of von Willebrand factor and necrotic cell death in primary human endothelial cells
Authors: Alexander T. Bauer, Elwira A. Strozyk, Christian Gorzelanny, Christoph Westerhausen, Anna Desch, Matthias F. Schneider, Stefan W. Schneider
Journal: Biomaterials (2011)
Immune Tolerance to Aspergillus fumigatus versus Allergic Bronchopulmonary Aspergillosis: roles of TSLP, OX40L, and Vitamin D
Authors: N. Nguyen, J.M. Pilewski, J.L. Kreindler, C. Steele, A. Ray, J.F. Alcorn, S.F. Ziegler, E. Hartigan, M. Kurs-Laskey, H. Rockette, J.K. Kolls
Journal: Journal of Allergy and Clinical Immunology (2010)
Reduction of Plasma Cholesterol Levels in Normal Men on an American Heart Association Step 1 Diet or a Step 1 Diet with Added Monounsaturated Fat
Authors: H N Ginsberg, S L Barr, A Gilbert, W Karmally, R Deckelbaum, K Kaplan, R Ramakrishnan, S Holleran, R B Dell
Journal: New England Journal of Medicine (1990)

Original Article from The New England Journal of Medicine — Reduction of Plasma Cholesterol Levels in Normal Men on an American Heart Association Step 1 Diet or a Step 1 Diet with Added Monounsaturated Fat
Rho Kinase–Mediated Vasoconstriction Is Important in Severe Occlusive Pulmonary Arterial Hypertension in Rats
Authors: Masahiko Oka, Noriyuki Homma, Laimute Taraseviciene-Stewart, Kenneth G. Morris, Donatas Kraskauskas, Nana Burns, Norbert F. Voelkel, Ivan F. McMurtry
Journal: Circulation Research (2007)

Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH). We have found previously that acute Rho kinase inhibition nearly normalizes PAH in chronically hypoxic rats that have no occlusive neointimal lesions. Here we examined whether Rho kinase–mediated vasoconstriction was also important in a rat model of severe occlusive PAH. Adult rats were exposed to chronic hypoxia (≈10% O 2 ) after subcutaneous injection of the vascular endothelial growth factor receptor inhibitor SUGEN 5416. Hemodynamic measurements were made in anesthetized rats after 2 weeks of hypoxia (early group) and 3 weeks of hypoxia plus 2 weeks of normoxia (late group). Both groups developed PAH, with greater severity in the late group. In the early group, intravenous fasudil was more effective than intravenous bradykinin, inhaled NO, or intravenous iloprost in reducing right ventricular systolic pressure. Despite more occlusive vascular lesions, fasudil also markedly reduced right ventricular systolic pressure in late-stage rats. Blood-perfused lungs from late-stage rats showed spontaneous vasoconstriction, which was reversed partially by the endothelin A receptor blocker BQ123 and completely by fasudil or Y-27632. Phosphorylation of MYPT1, a downstream target of Rho kinase, was increased in lungs from both groups of rats, and fasudil (intravenous) reversed the increased phosphorylation in the late group. Thus, in addition to structural occlusion, Rho kinase–mediated vasoconstriction is an important component of severe PAH in SUGEN 5416/hypoxia-exposed rats, and PAH can be significantly reduced in the setting of a severely remodeled lung circulation if an unconventional vasodilator is used.
The Compensation of Physicians Who Treat Patients Having Infusions at Home
Authors: Mark M. Applefeld
Journal: JAMA (1990)

To the Editor.—  Today's cost-conscious health care environment poses several dilemmas for physicians, one being when and how to send a patient home from the hospital. The diagnosis related group system, with its emphasis on designated lengths of stay, can result in patients being sent home quicker but sicker. Fortunately, with sophisticated, alternate-site health care services, many patients can now be treated at home. Home infusion therapy is a prime example of a cost-effective alternative to hospitalization for appropriate patients.  Unfortunately, physicians may not prescribe home infusion therapy for these patients. To many, home care represents loss of control—a feeling of no longer managing their patient. In addition, many physicians have concerns about possibilities of litigation should any adverse events occur when the patient is outside the traditional hospital setting. Discharging a patient to home care may also represent a significant loss of income. Thus, there is little incentive for
The study of blindness and technology can reveal the mechanisms of three-dimensional navigation
Authors: Achille Pasqualotto, Michael J. Proulx
Journal: Behavioral and Brain Sciences (2013)

Abstract Jeffery et al. suggest that three-dimensional environments are not represented according to their volumetric properties, but in a quasi-planar fashion. Here we take into consideration the role of visual experience and the use of technology for spatial learning to better understand the nature of the preference of horizontal over vertical spatial representation.
Survival is better indicator than mortality in geographic comparisons of health
Authors: P A West
Journal: BMJ (1998)

Outcome of pregnancy in women with insulin dependent diabetes Centralisation of care leads to better outcomeEditor-The finding of a persistently poor outcome of pregnancy in women with insulin dependent diabetes in two (northern) English regions is an important statement of the problem. 1 2 Both studies provide figures and show outcomes that are no different from those widely reported in the past.Unfortunately, neither give evidence of any degree of centralisation of obstetric or diabetic care, with on-site neonatal intensive care, although this is a proved means of improving the outcome of pregnancy for diabetic mothers. 3 The St Vincent declaration guidelines on the outcome of pregnancy, referred to in the accompanying editorial (p 263), are based on the Scandinavian reports held up as examples of good practice and state that "an interdisciplinary team should provide centralized diabetic pregnancy care in a hospital treating at least 20-30 cases a year.Pregnant diabetic
Measuring the Quality of Primary PCI for ST-Segment Elevation Myocardial Infarction
Authors: Frederick A. Masoudi
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Indication for Gleevec
Authors: Bernard A. Schwetz
Journal: JAMA (2002)

The FDA has approved imatinib mesylate capsules (Gleevec, Novartis Pharmaceutical Corp, East Hanover, NJ), an approved treatment for chronic myeloid leukemia, for the treatment of patients with unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST).
Note on Charcot's Joint Disease
Authors: R. R. Leeper
Journal: BMJ (1889)

THB BRZTI8XR MADICAL JOUJRNAL _ D. 14, low.feeling like malignant disease, but which proved to be the surface bf the pancres exposed by ulceration (see photograph).After pasing the inger well through the pylorus, I decided to close the stomach wound.This was done by a fine silk Lembert.'s suture with a reinforcing row outside the first.Convalescence was uncomplicated by any sickness, rise of tem- perature, or any other complication.The patient was fed for the hfrst three days on nutrient enemata, then on peptop ed food, and took solid food on the tenth day.She was a little sick (8 ounces) on the thirteenth day, but got up on the fifteenth day, and gradu- ally improved.She was tiek twice only in December, and was dicharged on January 1st, her weight at that date being 6 at. 5 lbs., or a gain of 9 lbs.since the operation.She still suffered at times, however, from epigastric pin.After her discharge from the hospital ehe continued well for three or f6ur montes, though there was occsional and slight sickness, and she walked out of doors.She tben, as she expressed it, began to suffer from the scanty suDplf of poor and indigestible food, and the pain and vomiting grauafly returned, and she died from exhaustion after an attak of diarbrea on September 20th, eleven months after operation.q I , ~~*Ca lty of stoniach laid open, showiit,l ltie projectiog ritig of the pylorus, ±k, and the ulceratedsur:aLes: A, pylorus; Is, utceated arets.2Post mnortetn Emamination.-Thisslhowed an absence of disease in any organ except the stomachl.This organ was much dilated, and lay almost entirelv to the left of thse mid line; stretching from the cicatrix on the abaominal wall to the anterior euirface of the stomach was a thin old adhesion.The pylorus was much thick- ened, and adherent to the under surface of the liver, and to the pancreas posterioriy.On opening the stomaclh, no sign of the incision in its walls could be seen, and, apart from the dilatation, 30 gr. always quieted him and produced sleep lasting some hours.CASE xiv.-Slitral disease.A middle-aged woman.30 gr. always produced sleep.CASE \x'.-Carcinoma of the pylorus.A woman sged 56.3gr.always' produced sleep better than morphine.CA-s xvI.-Chronic eczema.A man aged 40.30 gr. caused comfortable sleep.CAsE XvIr -Mitral regurgitstion and floating kidney.A woman aged 50.30 gr. produced sleep, altbough the floating kidney caused much pain.CASE XVITI.-Spasticparaplegia.A woman aged 56.20 gr.caused comfortable sleep.CASE xrx.-Phthisis, aortic disease, saturnine paralyia.A man aged 65. 20 gr.always produced sleep, but it took twelve hoursto act, so that if the medicine were given in tLe evening the pstient did not sleep duriog the night, but he slept all the next CASE ix.-Mitral regurgitation.An adult man.A severe cis'. 30gr. prodtuced comfort.utuesteel,.
Inflammatory Fibrous Histiocytoma: An Important Variant of Malignant Fibrous Histiocytoma Highly Responsive to Chemotherapy
Authors: MAN-CHIU POON
Journal: Annals of Internal Medicine (1982)

Inflammatory fibrous histiocytoma is a recently recognized variant of malignant fibrous histiocytoma. Patients managed with surgical excision or radiation therapy usually have had multiple recurrences, often with metastases. The disease is insidious but ultimately fatal. Four consecutive patients were treated with inflammatory fibrous histiocytoma with alkylating agents with or without anthracyclines and produced prolonged and sustained remissions. Inflammatory fibrous histiocytoma may be another highly chemotherapeutically responsive tumor that deserves active case identification for aggressive curative therapy.
Persistent parvovirus B19 infection and pure red cell aplasia in waldenström's macroglobulinemia: Successful treatment with high‐dose intravenous immunoglobulin
Authors: Marina Karmochkine, Eric Oksenhendler, Marianne Leruez‐Ville, Arnaud Jaccard, Frederic Morinet, Serge Herson
Journal: American Journal of Hematology (1995)
A CASE OF SECONDARY CARCINOMATOUS GROWTHS SIMULATING TUBERCULOUS HIP-JOINT DISEASE AND MILIARY TUBERCULOSIS
Authors: R. E. Lord, Chas. W. Buckley
Journal: BMJ (1906)

Txz IAnsu 9 the case but escaped observation.With regard to subjective senisationis, 17 cases alonie complainied of anly paini in the testis all(n 6 complained of pain in the scar.In nione could aily cause for tlle paini be discovered.Considerable difficulty was experienced in this part of the iniquiry, particularly wvitlh respect to objective paini oni account of imperfect educationi or dullness of thle individuals.The senisation of tlle testis wvas unialtered in 84 per cenit., definiitely iniereased in 9 per cenit., diminiishted in 5 per cenit., anid altogetlier lost in 2 per cenit.Twenity-six out of the 100 reported them- selves as nleitlher better nor worse for the oyerationl.At first sight this is disappoiniting, but it must be remem-
Spontaneous Extrusion of Hand Grenade Fragments From the Face 60 Years After Injury
Authors: P.-D. Ghislain
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal