tbuckley/cabot-search huggingface dataset:
Fluorine-18 FDG Dual-Head Gamma Camera Coincidence Imaging of Radiation Pneumonitis
Authors: PETER LIN, GEOFF DELANEY, JOHN CHU, HOSEN KIAT, NICK POCOCK
Journal: Clinical Nuclear Medicine (2000)

A 69-year-old man with inoperable stage I squamous cell carcinoma of the lung underwent a radical course of radiotherapy combined with platinum-based chemotherapy. Fluorine-18 fluorodeoxyglucose (FDG) imaging with a dual-head coincidence gamma camera system (Co-PET) diagnosed radiation pneumonitis 1 month after completion of radiotherapy, when the clinical and radiographic signs were atypical and more suggestive of carcinomatous lymphangitis. Treatment with oral steroids was begun based on FDG scan findings, with prompt clinical benefit as would be expected for radiation pneumonitis.
Prevention of Neonatal Group B Streptococcal Infection
Authors: David A. Eschenbach
Journal: New England Journal of Medicine (2002)

The highest annual death rate before the sixth decade of life occurs during the first year of life.1 Most deaths during the first year occur during the perinatal period, particularly between the onset of labor and 72 hours after birth. Infection, often acquired before birth, is one explanation. Because neonates have an immune response to microbes that is depressed relative to those of older children and adults, they have an increased risk of infection-related illness and death. Group B streptococci and Escherichia coli cause most cases of sepsis in neonates.Well-established risk factors for early-onset group B streptococcal sepsis (that . . .
AAP: Toxic Stress Threatens Kids’ Long-term Health
Authors: Bridget M. Kuehn
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increased F-18 FDG Pulmonary Uptake in Contrast Medium Aspiration on PET/CT Imaging
Authors: Eric Gontier, Jean-Louis Alberini, Myriam Wartski, Malik Al Nakib, Carine Corone, Alain-Paul Pecking
Journal: Clinical Nuclear Medicine (2005)

This case illustrates the possibility of increased FDG uptake in persistent lesions resulting from asymptomatic barium aspiration, which provokes a mild acute inflammatory and edematous reaction within hours, followed by macrophage accumulation, granulomatous inflammation, and fibrosis over succeeding days and months. Barium aspiration occurred during an esophagram 6 months before PET/CT scanning in a 54-year-old man who was seen for suspicion of recurrence of head and neck cancer. In case of minor aspiration, a simple cough is generally observed, but large amounts of barium aspiration can be fatal, especially in elderly people.
Chronic, Massive Thrombotic Obstruction of the Pulmonary Arteries
Authors: KENNETH M. MOSER, VERNON N. HOUK, ROBERT C. JONES, CHARLES C. HUFNAGEL
Journal: Circulation (1965)

Four patients with extensive, chronic pulmonary arterial thrombotic obstruction, are presented in whom thromboendarterectomy was attempted. The procedure was successful in two, both of whom are alive and well more than 2 years since surgery; it was unsuccessful in two, both of whom succumbed in the postoperative period. The clinical and laboratory diagnostic approach to such patients is discussed. Criteria for selection of operative candidates are reviewed and certain technical decisions considered. It is concluded that selected patients with chronic massive occlusion can be improved significantly by thromboendarterectomy, but further experience is required to improve criteria for the selection of surgical candidates. The poor experience with two patients in advanced right ventricular failure already has indicated that one essential factor in reducing surgical risk is diagnosis prior to overt cardiac decompensation.
Abstract 3407: Induction of G-protein coupled receptor-64 (GPR64) in Ewing Tumors supports angiogenesis and metastatic spread
Authors: Günther H. Richter, Annette Fasan, Sabine Rössler, Diana Löwel, Martin S. Staege, Stefan Burdach
Journal: Cancer Research (2010)

Abstract Metastatic spread in Ewing Tumors (ET) is mostly hematogenous and malignant features have been shown to correlate with hypoxia and angiogenesis. Our microarray analysis confirmed an endothelial signature of this tumor and revealed the G-protein coupled receptor-64 (GPR64), an orphan receptor with normal expression restricted to human epididymis, to be highly induced in ET. Down-regulation of GPR64 in ET lines by RNA interference did not reduce their proliferative capacity in vitro as measured by plastic adherence dependent proliferation or contact independent growth in colony forming assays. However, inhibition of GPR64 expression impaired endothelial differentiation of ET in tube forming assays. Furthermore, GPR64 suppression inhibited local tumor development and metastatic spread of ET in immuno-deficient Rag2−/−γC−/− mice. The observed inhibition of metastatic spread correlated with a reduced proteolytic activity and invasiveness of such cells in vitro. Further microarray analysis after GPR64 knock down revealed a GPR64-mediated induction of VGEF receptor 1 ligand Placental Growth Factor (PGF) in ET. PGF itself was found to be induced by EWS-FLI1 in mesenchymal stem cells. Subsequent repression of PGF expression resulted in a phenotype of ET similar to the one observed after GPR64 knock down. GPR64 induction in ET supports invasiveness and shapes angiogenesis by induction of critical effectors. It therefore seems to play a central role in the pathogenesis of this tumor. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3407.
Targeting interleukin 18 with interleukin 18 binding protein
Authors: C. A Dinarello
Journal: Annals of the Rheumatic Diseases (2000)

A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of the IL1 receptor type II. However, unlike soluble cytokine receptors, IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is a secreted protein and not cleaved from the cell surface. IL18BP is naturally occurring and was isolated from the urine of healthy subjects. Because IL18 is an important inducer of interferon γ (IFNγ), IL18BP suppresses the production of IFNγ resulting in reduced T-helper type 1 immune responses. There are four human and two mouse isoforms—resulting from mRNA splicing and found in various cDNA libraries. Each of these IL18BP isoforms have been expressed, purified and assessed for binding and neutralisation of IL18 biological activities. Two human IL18BP isoforms exhibited the greatest affinity for IL18 with a rapid on-rate, a slow off-rate and a dissociation constant (kDa) of 399 pM. The two other isoforms with an incomplete immunoglobulin domain were unable to neutralise IL18. The two human isoforms that possess a complete immunoglobulin domain, neutralise &gt;95% IL18 at a molar excess of two. Molecular modelling identified a large mixed electrostatic and hydrophobic binding site in the immunoglobulin domain of IL18BP, which could account for its high affinity binding to the ligand. These high affinity forms may be ideally suited for blocking IL18 in human disease. It is likely that preferential secretion of high affinity functional and non-functional isoforms of IL18BP affect the immune response and the outcome of disease.
Depressive Symptoms, Satisfaction With Health Care, and 2-Year Work Outcomes in an Employed Population
Authors: Benjamin G. Druss, Mark Schlesinger, Harris M. Allen
Journal: American Journal of Psychiatry (2001)

The relationship of depressive symptoms, satisfaction with health care, and 2-year work outcomes was examined in a national cohort of employees.A total of 6,239 employees of three corporations completed surveys on health and satisfaction with health care in 1993 and 1995. This study used bivariate and multivariate analyses to examine the relationships of depressive symptoms (a score below 43 on the Medical Outcomes Study Short-Form Health Survey mental component summary), satisfaction with a variety of dimensions of health care in 1993, and work outcomes (sick days and decreased effectiveness in the workplace) in 1995.The odds of missed work due to health problems in 1995 were twice as high for employees with depressive symptoms in both 1993 and 1995 as for those without depressive symptoms in either year. The odds of decreased effectiveness at work in 1995 was seven times as high. Among individuals with depressive symptoms in 1993, a report of one or more problems with clinical care in 1993 predicted a 34% increase in the odds of persistent depressive symptoms and a 66% increased odds of decreased effectiveness at work in 1995. There was a weaker association between problems with plan administration and outcomes.Depressive disorders in the workplace persist over time and have a major effect on work performance, most notably on "presenteeism," or reduced effectiveness in the workplace. The study's findings suggest a potentially important link between consumers' perceptions of clinical care and work outcomes in this population.
Paul Peter Carbone, MD
Authors: James A. Stewart
Journal: Journal of Clinical Oncology (2003)

Article Tools IN MEMORIAM Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.09.017 Journal of Clinical Oncology - published online before print September 21, 2016 Paul Peter Carbone, MD James A. StewartxJames A. StewartSearch for articles by this author Show More University of Wisconsin, Madison, WI https://doi.org/10.1200/JCO.2003.09.017 Full Text PDF Figures and Tables "Paul Peter Carbone, MD." Journal of Clinical Oncology, 21(22), pp. 4071–4072© 2003 by American Society of Clinical Oncology
The Quiet Therapies: Japanese Pathways to Personal Growth
Authors: Paul Chodoff
Journal: JAMA (1981)

The "Quiet Therapies" are a group of five Buddhist-based psychotherapies from Japan, so named by the author because they all require the client to spend time in some form of isolated introspection. To call them "psychotherapies" in the Western sense of that term, however, is somewhat misleading, since the purpose of these procedures is not to cure or ameliorate symptoms but rather to inculcate an uncomplaining acceptance so that a family and social contribution can be made by the sufferer in spite of symptomatic disability. The best known of the five is Morita psychotherapy, a regimen in which a period of isolated bed rest, during which the client cultivates memories and introspections and keeps a diary, is succeeded by gradually increasing amounts of useful activity and social interaction during brief interviews with a Morita therapist, whose injunctions and admonitions encourage proper social behavior. The patient is considered cured when he
Abstract 1541: M2 macrophages co-cultured with prostate cancer cells promote osteoblast differentiation mediated by BMP-2 and BMP-7.
Authors: Lihui Wang, Xin Huang, Jianhua Wang, Yi Lu
Journal: Cancer Research (2013)

Abstract Prostate cancers frequently metastasize to bone and cause predominantly osteoblastic lesions. When tumor cells metastasize to bone, they interact with the bone microenvironment. Bidirectional interactions between prostate cancer cells and bone microenvironment increase expression of cytokines, chemokines and adhesion molecules. These factors can be produced by tumor cells as well as bone marrow cells including osteoclasts, osteoblasts/stromal cells and macrophages. It has been demonstrated that M2 macropahge enhanced tumor growth, survival and metastasis. However, whether M2 macropahges play roles in prostate cancer-induced osteoblastic lesions, specifically in osteoblast differentiation is unknown. We initially isolated M2 macrophages from primary murine bone marrow cells culturing with IL-4 and IL-13. Then M2 macrophages were co-cultured with or without prostate cancer C4-2B or LNCaP cells at ratio 5:1. Then the conditioned media (CM) from M2 co-cultures were collected. We incubated murine bone marrow cells or MC3T3 E1 cells with different concentrations of the CM and performed Von Kossa Staining. We found that the co-cultured CM, but not the CM collected from either macrophages or prostate cancer cells, significantly induced bone marrow cells or MC3T3 E1 mineralization in vitro. This induction was partially blocked by anti-BMP-2 and anti-BMP-7 neutralizing antibodies. We further observed that the co-cultured CM significantly induced alkaline phosphatase (ALP) and osteocalcin (OCN) production. Finally, we determined the cytokine productions from the co-cultured CM by using ELISA. The production of BMP-2 and BMP-7 were detected. The conditioned media collected from M1 macrophage were used as corresponding and negative controls throughout the whole study. We concluded that M2 macrophages co-cultured with prostate cancer cells promote osteoblast differentiation mediated by BMP-2 and BMP-7. Supported by NSF projects 81171993 and 81272415; NSF key project 81130046; 973 Grant (2009CB918902); Guangxi projects 201201ZD004 and 2012GXNSFCB53004. Citation Format: Lihui Wang, Xin Huang, Jianhua Wang, Yi Lu. M2 macrophages co-cultured with prostate cancer cells promote osteoblast differentiation mediated by BMP-2 and BMP-7. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1541. doi:10.1158/1538-7445.AM2013-1541
Imaging jumps ahead with PETT
Authors: W. Check
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Magnetic resonance–guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells
Authors: Brad P Barnett, Aravind Arepally, Parag V Karmarkar, Di Qian, Wesley D Gilson, Piotr Walczak, Valerie Howland, Leo Lawler, Cal Lauzon, Matthias Stuber, Dara L Kraitchman, Jeff W M Bulte
Journal: Nature Medicine (2007)
A FRET‐Based Dual‐Targeting Theranostic Chimeric Peptide for Tumor Therapy and Real‐time Apoptosis Imaging
Authors: Kai Han, Yun Liu, Wei‐Na Yin, Shi‐Bo Wang, Qi Xu, Ren‐Xi Zhuo, Xian‐Zheng Zhang
Journal: Advanced Healthcare Materials (2014)

A FRET-based chimeric peptide is reported to mediate specific tumor cell uptaking and apoptosis. Importantly, this chimeric peptide is fluorescence quenched (OFF). Once the apoptosis is initiated and propagated, green fluorescence is lighted up rapidly (ON), achieving simultaneous tumor therapy and real-time apoptosis monitoring. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Effects of Atropine Mucate
Authors: W. N. Rollason
Journal: BMJ (1953)

<h3>Abstract</h3> An animal’s movements and internal state generate an “internal backdrop” of activity that is dynamically modulated. During behavior, this internal backdrop interacts with signals arising from incoming sensory stimuli and may have a substantial impact on task-related computations, like those underlying decision-making. To understand the joint effects of internal backdrop and task-imposed variables, we measured neural activity across the entire dorsal cortex of task-performing mice. We characterized internal backdrop using multiple measures of self-generated parameters including pupil diameter, whisking and body motion. Surprisingly, internal backdrop dominated neural activity across the entire cortex, dwarfing task-related variables and even sensory stimuli. Single neurons in frontal cortex were likewise dominated by internal backdrop. A linear model allowed us to account for multiple dimensions of internal backdrop and uncover hidden signatures of task-related activity. We show that complex, ongoing behavior fundamentally shapes neural activity throughout cortex and must be accounted for when studying decision-making. <h3>Highlights</h3> We imaged cortex-wide neural activity during auditory and visual decisions in mice. Cortical activity was surprisingly similar during sensory-guided versus random decisions. Movement and state variables vastly outperformed task variables in predicting neural activity. A linear model revealed hidden task-related activity in brain areas and single neurons.
Mobilized bone marrow stem cells accelerated reendothelialization, reduce vascular inflammation, and prevent restenosis after intravascular radiation
Authors: Hyun-Jai Cho, Hyo-Soo Kim, Dae-Hee Kim, Seil Oh, In-Ho Chae, Byung-Hee Oh, Myoung-Mook Lee, Young-Bae Park, Yun-Shik Choi
Journal: Journal of the American College of Cardiology (2003)
A further evaluation of the clinical use of specific IgE antibody testing in allergic diseases
Authors: L. Söderström, A. Kober, S. Ahlstedt, H. de Groot, C.‐E. Lange, R. Paganelli, M. H. W. M. Roovers, J. Sastre
Journal: Allergy (2003)

Background: The evaluation and interpretation of the results from blood tests measuring specific immunoglobulin E (IgE) antibody concentration is currently made using the dichotomized result from the test despite a quantitative result is obtained. It has been shown that different levels of IgE antibodies, assessed by blood test and skin prick test, may have a relation to presence of symptoms, implying that there is more information in a quantitative result than in the dichotomous – positive or negative. Objective: To investigate the clinical utility of quantification of IgE antibodies in the diagnosis of allergic patients and whether such procedure has any advantage to the presently dichotomously used sensitivity and specificity at a fixed cut‐off. Methods: Data from a previously published study (R. Paganelli, I.J. Ansoteugi, J. Sastre, C.‐E. Lange, M.H.W.M. Roovers, H. de Groot, N.B. Lindholm, P.W. Ewan, Allergy , 1998; 53) analysing diagnosis of allergic patients in four different clinics were re‐evaluated. In the original study consecutive patients with suspected IgE‐mediated allergy had been examined and evaluated according to the clinical routine at each clinic, using case history, physical examination, skin tests and laboratory tests, except the test to be evaluated, and given an ‘doctors’ allergen‐specific diagnosis’ as positive or negative. In the present study the relation between ‘doctors’ allergen‐specific diagnosis’, expressed as pos/neg, and the quantitative levels of specific IgE antibody concentration was analysed using a logistic regression model. This presentation of results was also compared with the more common characteristics of sensitivity and specificity, and also with Receiver–operator characteristics (ROC) curves. Results: The used logistic model described the relationship between allergen‐specific diagnosis in each study and the levels of IgE antibodies. The shape of the curve illustrated the physicians’ disposition for a positive diagnose in the study, in relation to the specific IgE antibody level. Differences in the shape of the curve was found both between allergens within clinics and between clinics for the same allergen. No association could be demonstrated between prevalence and shape of the curve. Conclusions: Conventional sensitivity/specificity figures or ROC concepts only use the qualitative statement of whether IgE is present or not. A risk assessment using the quantitative level of IgE antibody to an allergen increases the utility of the information in clinical context compared with a qualitative statement of whether IgE is present or not. The quantification demonstrated the link between specific IgE antibodies and allergic reactions. The use of objective, well performing quantitative tests should help improve diagnostic accuracy and might provide a way for the patient to understand and manage his or her daily situation and risk for reactions.