tbuckley/cabot-search huggingface dataset:
Kartagener's Syndrome with Motile Spermatozoa
Authors: Magni S. Jonsson, James R. McCormick, Concettina G. Gillies, Bernard Gondos
Journal: New England Journal of Medicine (1982)

Immotile cilia syndrome is an inherited disorder characterized by recurrent sinopulmonary infections, reduced fertility in women, and sterility due to immobile spermatozoa in men.1 , 2 When situs inversus is encountered — in about half the cases — the disorder is referred to as Kartagener's syndrome.The clinical effects of this syndrome are caused by the inability of ciliated structures to beat effectively.3 , 4 In the respiratory tract this inability presumably causes impaired clearance of mucus and inhaled particulates and results in the chronic infections of the sinuses and bronchial tree that are so characteristic of the disease. The genetic defect in ciliary . . .
Adhesion of human enterotoxigenic Escherichia coli to human mucus secreting HT-29 cell subpopulations in culture.
Authors: S Kerneis, M F Bernet, M H Coconnier, A L Servin
Journal: Gut (1994)

Enterotoxigenic Escherichia coli (ETEC) bearing the fimbrial colonisation factor antigens CFA/I, CFA/II, CFA/III, and the non-fimbrial antigen 2230 were tested for their ability to adhere to two cultured human intestinal HT-29 mucus secreting cell subpopulations. These populations are referred to as HT29-MTX and HT29-FU, which differ in the amount of secreted mucins and in their gastric or colonic mucin immunoreactivity respectively. Adherence of radiolabelled bacteria to cell monolayers infected apically was assessed. All ETEC strains adhered to the mucus secreting HT29-FU subpopulation, which secretes mucins of colonic immunoreactivity. Visualisation of bacteria by scanning electron microscopy showed that ETEC bound to the HT29-FU cells possessing a brush border, but not to the mucus and that ETEC binding developed as a function of cell differentiation. The adhesion of ETEC to cells possessing a brush border and to mucus secreting cells was also analysed by indirect immunofluorescence in HT29-MTX cells, which secrete mucins of gastric immunoreactivity. Fluorescein isothiocyanate labelling using specific anti-CFA/I antibody was used to show ETEC; rhodamine isothiocyanate labelling using a monoclonal antibody (designated M1) against purified human gastric mucus was used to detect secreted mucins, and rhodamine isothiocyanate labelling using a monoclonal antibody (designated 4H3) against human dipeptidylpeptidase IV was used to show cells possessing a brush border. Binding of bacteria colocalised with dipeptidylpeptidase IV of enterocytes and not with mucins.
Remission of Generalized Anxiety Disorder after 6 Months of Open-Label Treatment with Venlafaxine XR
Authors: Karl Rickels, Bijan Etemad, Moira A. Rynn, Falk W. Lohoff, Laura A. Mandos, Robert Gallop
Journal: Psychotherapy and Psychosomatics (2013)

Remission has become one of the leading outcome criteria in clinical trials. Data collected by this research group assessed the rate of remission after 6 months of treatment of generalized anxiety disorder (GAD) with venlafaxine XR, to search for predictors of remission and to define how early on in treatment later remission can be predicted.Two hundred sixty-eight patients with a GAD diagnosis enrolled into an open-label 6-month-treatment trial with venlafaxine XR (75-225 mg/day). Remission was defined by a Hamilton anxiety scale total score ≤7. Logistic regression approaches were used to find out how early on in treatment later remission could be predicted, as well as to determine predictors of remission. In addition, adverse events were also followed over time.While the total enrolled patient sample (n = 268) had a remission rate of 53%, 6-month completers (n = 159) had a remission rate of 79%. The only statistically significant predictor of remission, independent of baseline anxiety and depression levels, was a low Eysenck neuroticism score. The remission status outcome could best be predicted after 8 weeks of treatment when a CGI-I score of 1 or 2 predicted later remission with 78% accuracy and later nonremission with 91% accuracy. The incidence of adverse events decreased over the 6-month period, with sexual adverse events decreasing the least.The only significant predictor of remission was a low score on the Eysenck neuroticism scale. The earliest reliable prediction of later remission, based on improvement, could be made after 8 weeks of treatment with 91% accuracy.
Methotrexate vs. ciclosporin in the treatment of severe atopic dermatitis in children: a critical appraisal
Authors: T. Tsakok, C. Flohr
Journal: British Journal of Dermatology (2014)

Journal Article Methotrexate vs. ciclosporin in the treatment of severe atopic dermatitis in children: a critical appraisal Get access T. Tsakok, T. Tsakok Guy's and St Thomas' Hospital NHS Foundation Trust London U.K Search for other works by this author on: Oxford Academic Google Scholar C. Flohr C. Flohr Department of Paediatric Dermatology St John's Institute of Dermatology Guy's & St Thomas' Hospital NHS Foundation Trust and King's College London London U.K Correspondence Carsten Flohr. E‐mail: carsten.flohr@kcl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 3, 1 March 2014, Pages 496–498, https://doi.org/10.1111/bjd.12820 Published: 01 March 2014
A piece of my mind. Panic
Authors: E. Notini
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thyroid Function Screening in Psychiatric Patients
Authors: Kenneth L. Cohen
Journal: JAMA (1979)

Abnormalities in levels of total thyroxine and thyroxine binding capacity were common in a group of 480 newly admitted psychiatric patients. The estimated free thyroxine (EFT<sub>4</sub>) level was elevated in 43 patients (9%). In 27 of these patients, the level of EFT<sub>4</sub>became spontaneously normal, usually within a two-week period (acute "stress hyperthyroidism"). The level of EFT<sub>4</sub>was decreased in 42 patients (9%). In 16 of these patients, the level became spontaneously normal; the etiology of this apparent acute hypothyroidism is unclear. The yield of new cases of primary hyperthyroidism and hypothyroidism was low, but a presumptive diagnosis of secondary hypothyroidism was made in eight patients. In addition, nine patients with known thyroid disease were taking inadequate or excessive replacement therapy. Thyroid function screening tests are of value in psychiatric patients. (<i>JAMA</i>242:254-257, 1979)
Physical Injuries and Fatalities Resulting From the Oklahoma City Bombing
Authors: S. Mallonee, S. Shariat, G. Stennies, R. Waxweiler, D. Hogan, F. Jordan
Journal: JAMA (1996)

To provide an epidemiologic description of physical injuries and fatalities resulting from the April 19, 1995, bombing of the Alfred P. Murrah Federal Building in Oklahoma City.Descriptive epidemiologic study of all persons injured by the bombing and of all at-risk occupants of the federal building and 4 adjacent buildings. Data were gathered from hospital emergency and medical records departments, medical examiner records, and surveys of area physicians, building occupants, and survivors.All persons known to have been exposed to the blast.Characteristics of fatalities and injuries, injury maps, and injury rates by building location.A total of 759 persons sustained injuries, 167 persons died, 83 survivors were hospitalized, and 509 persons were treated as outpatients. Of the 361 persons who were in the federal building, 319 (88%) were injured, of whom 163 (45%) died, including 19 children. Persons in the collapsed part of the federal building were significantly more likely to die (153/175, 87%) than those in other parts of the building (10/186, 5%) (risk ratio [RR], 16.3; 95% confidence interval [CI], 8.9-29.8). In 4 adjacent buildings, injury rates varied from 38% to 100%; 3 persons in these buildings and 1 person in an outdoor location died. The most frequent cause of death was multiple injuries. Among survivors, soft tissue injuries, fractures, sprains, strains, and head injuries were most common; these injuries were most often caused by flying glass and other debris and collapsed ceilings.The Oklahoma City bombing resulted in the largest number of fatalities of any terrorist act in the United States, and there were 4 times as many nonfatal injuries as fatalities. Disaster management plans should include the possibility of terrorist bombing, and medical preparedness should anticipate that most injuries will be nonfatal. The role of building collapse in fatal injuries should be considered in the design of buildings at high risk of being bombed so as to reduce injuries.
Diabetes UK replies to Dr Aseem Malhotra
Authors: B. Young
Journal: BMJ (2013)

<h3>ABSTRACT</h3> Several Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) neutralising monoclonal antibodies (mAbs) have received emergency use authorisation by regulatory agencies for treatment and prevention of Coronavirus Disease 2019 (COVID-19), including in patients at risk for progression to severe disease. Here we report the persistence of viable SARS-CoV-2 in patients treated with sotrovimab and the rapid development of spike gene mutations that have been shown to confer high level resistance to sotrovimab <i>in vitro</i>. We highlight the need for SARS-CoV-2 genomic surveillance in at risk individuals to inform stewardship of mAbs use and prevent potential treatment failures.
The Cancer Diaspora: Metastasis beyond the Seed and Soil Hypothesis
Authors: Kenneth J. Pienta, Bruce A. Robertson, Donald S. Coffey, Russell S. Taichman
Journal: Clinical Cancer Research (2013)

Abstract Do cancer cells escape the confinement of their original habitat in the primary tumor or are they forced out by ecologic changes in their home niche? Describing metastasis in terms of a simple one-way migration of cells from the primary to the target organs is an insufficient concept to cover the nuances of cancer spread. A diaspora is the scattering of people away from an established homeland. To date, “diaspora” has been a uniquely human term used by social scientists; however, the application of the diaspora concept to metastasis may yield new biologic insights as well as therapeutic paradigms. The diaspora paradigm takes into account, and models, several variables including: the quality of the primary tumor microenvironment, the fitness of individual cancer cell migrants as well as migrant populations, the rate of bidirectional migration of cancer and host cells between cancer sites, and the quality of the target microenvironments to establish metastatic sites. Ecologic scientific principles can be applied to the cancer diaspora to develop new therapeutic strategies. For example, ecologic traps – habitats that lead to the extinction of a species – can be developed to attract cancer cells to a place where they can be better exposed to treatments or to cells of the immune system for improved antigen presentation. Merging the social science concept of diaspora with ecologic and population sciences concepts can inform the cancer field to understand the biology of tumorigenesis and metastasis and inspire new ideas for therapy. Clin Cancer Res; 19(21); 5849–55. ©2013 AACR.
Serum Cholesterol in Man: Diet Fat and Intrinsic Responsiveness
Authors: ANCEL KEYS, JOSEPH T. ANDERSON, FRANCISCO GRANDE
Journal: Circulation (1959)

Data obtained from a number of dietary experiments in man yield a formula by which the responses in serum cholesterol to changes in diet can be predicted. In this paper the reliability of this formula is tested and the effects of various types of fatty acids on serum cholesterol are investigated.
TCT-732 Predictors of Aortic Arch Type: Implications in Patients with Severe Aortic Stenosis Being Evaluated for Transcatheter Aortic Valve Replacement
Authors: Rajiv Tayal, Benjamin LeSar, Ahmed Seliem, Spas Kotev, Alan Weinberg, Afroditi Emporelli, Zafar Iqbal, Omar Hasan, Deepa Iyer, Gurinder Rana, Manjusha Anna, Humayun Iftikhar, Patricia Panfile, Marc Cohen, Najam Wasty
Journal: Journal of the American College of Cardiology (2013)
INSULIN FAT ATROPHY A TRAUMATIC ATROPHIC PANNICULITIS
Authors: H. Avery
Journal: BMJ (1929)

It is initeresting to consider what part the autonomic hypertropliy played in the overgrowth of the limb, Were they parts of the same pro-_cess, or were the hypertrophied sympathetic nerves responsible, evein partially, for the general- ized 'overgrowth of the limb, thrboughl disordered vasa-con- strictor anid secretory im-The patient's motlher (Fig. 4), who was abouit 40 yeals of age, was 5 feet in lheight, and her physique suggested aehondroplasia.The patient was hier only chiildl.Despite a certain degree of deformi ity .,,A,-: of helr infanit's limb at birth, therie was o spec4ial tr'ouble at the coefinement.She said that her parenits wer1e niorIi, but that her granidmiiother showed similar lesions to hers, w1-hichl consisted of over 2,000 minute cutaneous tunours and ... .. scattered subcuttaneous swell-I 1gs; freckles andtl patellh .)Igmnentation of the skin; FIG, 4.4'afieut's mother.and a diffuse swellinig on the dorsuna of thie riglht leg, whIiiel w-as stated to be similar to the initial le0ion dfeetiumg eri 80soil.
PERORAL ADMINISTRATION OF UNDECYLENIC ACID IN PSORIASIS
Authors: H. HARRIS PERLMAN
Journal: JAMA (1949)

In recent years, certain fatty acids have been found to exert antifungal activity on the human skin and to be valuable in both prevention and treatment of some of the superficial dermatomycoses. 1 As far as we have been able to discover, practically nothing is known to date about the pharmacologic, toxicologic and therapeutic potentialities of the oral administration of these acids. However, previous studies 2 appear to justify the assumption that a portion of an ingested amount of certain fatty acids may retain chemical characteristics in the fat of the tissue and in the sebum. The selection of an unsaturated acid appeared of special interest for the purposes of the present studies.  Our first attempts were designed to investigate the possibility that the oral administration of undecylenic acid might have a therapeutic effect on recalcitrant fungous infections, in particular on tinea capitis (Microsporon audouini) and on onychomycosis.  Preceding its
ANIMAL EXPERIMENTS WITH VON RUCK'S NEW TUBERCULOPROTEINS
Authors: R. S. CUMMINGS
Journal: JAMA (1913)

InThe Journal, May 18, 1912, appeared a preliminary announcement by Karl von Ruck 1 of his discovery of a tuberculin with which he asserted that he could produce immunity to tuberculosis in both man and animals.  Later he issued a pamphlet in which was given briefly his method of making this vaccine and the protocols of his experiments by which he demonstrated immunity. Also in another article 2 von Ruck discussed the subject in a little more elaborate way than that taken in his pamphlet.  His tuberculin, or vaccine as he termed it, contained in each cubic centimeter 10 mg. of protein of tubercle bacilli and a small amount of fatty extractives. In children this was injected in doses of from 0.05 c.c. to 0.6 c.c., depending on the age and number of doses given. One or two doses were given, but when two were used neither was so
Regional survey of femoral neck fractures.
Authors: S C Gallannaugh, A Martin, P H Millard
Journal: BMJ (1976)

In the South-west Thames Region 2619 patients (2105 women and 514 men) were discharged with a diagnosis of femoral neck fracture in 1974. The equivalent of a 250-bedded hospital was occupied throughout the year. The incidence, average length of stay, and mortality rate rose with increasing age and there were differences in these indices in the five health areas. These results confirm the enormous burden placed on the hospital service by patients with fracture of the femoral neck but suggest that differences in practice in the five areas may contribute to the size of the problem.
Lymphadenopathy Two Years Later
Authors: Paul E. Ogden
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 July 1990Lymphadenopathy Two Years LaterPaul E. Ogden, MDPaul E. Ogden, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-1-84_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In 1988, we reported what we believed to be an unusual reaction to fish oil supplementation (1). We described the case of a patient with tender cervical adenopathy in anterior and posterior cervical regions, fever, chills, myalgias, and an elevated sedimentation rate that resolved after lymph node biopsies and with discontinuation of fish oil supplementation. The patient reported resumption of symptoms when fish oil was resumed. The initial lymph node biopsies were reported as showing reactive hyperplasia with prominent histiocytosis. Cell surface markers were all negative.Subsequent events place our earlier diagnosis of reactive lymphadenopathy in question....Reference1. Ogden P, Piziak V, Cain P, Carpentier W, and Havemann D. Reactive lymphoid hyperplasia after omega-3 fatty acid supplementation [Letter]. Ann Intern Med. 1988;109:843-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Paul E. Ogden, MDAffiliations: Scott and White Memorial Hospital Temple, Texas 76508 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1990Volume 113, Issue 1Page: 84-84KeywordsBiopsyFeversLymph nodesMyalgiaOils ePublished: 1 December 2008 Issue Published: 1 July 1990 PDF downloadLoading ...
FDG-PET/CT scan of inflammatory spondylodiscitis lesions in ankylosing spondylitis, and short term evolution during anti-tumour necrosis factor treatment
Authors: D Wendling
Journal: Annals of the Rheumatic Diseases (2005)

hydrocephalus (fig 1).Because of the hydrocephalus, it was neurologically advisable not to perform a cerebrospinal fluid puncture.There was no indication of tuberculosis (chest x ray examination, tuberculin test, sputum culture) or any other infection.The neoplasia investigation was also negative.An anamnestic investigation showed that there was no need to use ibuprofen or sulindac.When the situation became life threatening we initiated immunosuppressive treatment with cyclophosphamide (100 mg/day), as well as intravenous steroids (100 mg) initially.The initial intravenous cortisone treatment relieved the headache symptoms.Follow up examinations for up to 1 year (every 3 months) showed remission of clinical and MRI findings with this treatment (fig 2).Stable partial remission occurred after 8 months, and oral administration of cyclophosphamide was stopped.Treatment to preserve remission was changed to azathioprine (100 mg).The prednisone dose was finally reduced to 5 mg.
Simple Weight-reducing Diet
Authors: H. L. Marriott
Journal: BMJ (1949)

Physician With Charge of Out-patients, Middlesex Hospital Fifteen years ago I devised a reducing diet, and have since used it for a large number of patients.The essential instructions are as follows:1. Eat or drink as much as you like (or can get) of Lean meat, poultry, game, rabbit, hare, liver, kidney, heart, sweetbread-cooked in any way, but without addition of flour, breadcrumbs, or thick sauces.Fish (not tinned), boiled or steamed only; no thick sauce.Eggs, boiled or poached only.Potatoes, boiled, steamed, or baked in skins, but not fried, roast, saut6, or " chips "; not potato powder.Other vegetables of all kinds (fresh, tinned, or dried) cooked in any way not involving the use of fat.Salad and tomatoes without oil or mayonnaise.Beetroot, radishes, watercress, parsley.Fresh fruit of any kind, including bananas.Also bottled fruit if bottled without sugar.Not tinned or dried fruits (including dates, figs, and raisins).Sour pickles, not sweet pickles or chutneys.Clear soup, broth, " bovril," " oxo," " marmite."Salt, pepper, mustard, vinegar, Worcester sauce (no other sauces).Saccharin for sweetening.Water, soda-water, and non-sweetened mineral waters.Tea and coffee (milk only as allowed below).2.You may have milk (not condensed) up to half a pint (284 ml.) daily.No cream.3.You may have three very small pieces of bread per day and take them either one at each main meal or all three at one meal as desired (" very small " means not exceeding 1 oz.- 28 g.).4. You may have nothing else whatever; particularly note that this means:No butter, margarine, fat, or oil (except for cooking meat, not fish).No sugar, jam, marmalade, honey, sweets, chocolate, cocoa.No puddings, ices, dried or tinned fruits, nuts.No bread (except as above), cake, biscuits, toast, patent reducing breads, cereals, oatmeal, "all-bran," " ryvita,"" vitawheat.