tbuckley/cabot-search huggingface dataset:
Afterload reduction with vasodilators and diuretics decreases mitral regurgitation during upright exercise in advanced heart failure
Authors: Lynne Warner Stevenson, Richard C. Brunken, Dalila Belil, Maleah Grover-McKay, Markus Schwaiger, Heinrich R. Schelbert, Jan H. Tillisch
Journal: Journal of the American College of Cardiology (1990)
Adult (Not Internal) Medicine
Authors: Alvin Lee Block
Journal: Annals of Internal Medicine (1998)

Letters1 June 1998Adult (Not Internal) MedicineAlvin Lee Block, MDAlvin Lee Block, MDNapa, CA 94559Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-11-199806010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In his editorial [1], Dr. Goldman offers some attractive reasons for replacing the term internal medicine with one that is more accurately descriptive and compatible with current health care delivery systems. But I am not yet persuaded.That some patients do not fully understand the nature and functioning of the internist is so, but Dr. Goldman's characterization of the numbers of patients who do understand as “the occasional patient” is, I respectfully suggest, literary hyperbole, intended to create interest and emphasis but lacking actual verification. If my informal sampling is the equivalent of Dr. Goldman's informal survey, ...References1. Goldman L. Adult (not internal) medicine [Editorial]. Ann Intern Med. 1997; 127:835-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: Napa, CA 94559 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPatient perceptions of the capabilities of internists: a multi-center survey11The opinions or assertions contained herein are the private views of the authors and not to be construed as official policy of the Department of the Army, the Department of Defense, or the Department of Veterans Affairs. 1 June 1998Volume 128, Issue 11Page: 957KeywordsHealth careHistory of medicine Issue Published: 1 June 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A 10 year single centre experience of percutaneous and endoscopic extraction of bile duct stones with T tube in situ.
Authors: E Nussinson, S R Cairns, D Vaira, J F Dowsett, R R Mason
Journal: Gut (1991)

A non-randomised single centre study of 226 consecutive patients referred over 10 years with retained common bile duct stones and a T tube in situ or a cholecystostomy tube are reported. Percutaneous extraction was attempted in 204 and endoscopic extraction in 68 patients. Percutaneous clearance was achieved in 158 (77.5%) patients and endoscopic clearance in 52 (76.5%) patients. Six of 153 (3.9%) patients followed after percutaneous treatment suffered major complications (pancreatitis, cholangitis, or tract perforation). Three of 67 (44%) patients followed after endoscopic treatment suffered major complications (pancreatitis, cholangitis, or bleeding). When the initial method of treatment failed, the alternative was used, resulting in an overall success rate of bile duct clearance of 94.3%. It is concluded that percutaneous and endoscopic methods of bile duct clearance in patients with a T tube in situ are equally effective, carrying similar complication rates. This study has helped to clarify the indications and efficacy of these alternative treatments.
HYPNOTISM IN THE TREATMENT OF DISEASE.
Authors: U. O. B. WINGATE
Journal: JAMA (1898)

From the earliest period in the history of the healing art, there has always been a strong tendency to accept any mysterious or unknown agency in the treatment of disease; more especially is this acceptance favored by the less learned in science, and among those afflicted there is always found a large clientage who are ready to be operated on by anything surrounded by mystery or pertaining in any way to the occult. Hypnotism, undoubtedly, owes to the mysticism that surrounds it its existence and practice. If it were better understood, no doubt it would be neglected and soon forgotten with the host of other agencies that have existed in the past and lost their charm as they became understood. To the scientific physician it fails to create confidence enough to be of much use, and its employment is now apparently largely in the hands of that class of practitioners
Acidaemia and Salicylate Poisoning in Adults
Authors: A. T. Proudfoot, S. S. Brown
Journal: BMJ (1969)

A review of the arterial acid-base status on admission to hospital of 62 adults with severe salicylate poisoning showed that arterial pH was normal or high in most patients, but low in 8. The mean plasma salicylate concentrations of the acidaemic and nonacidaemic patients were similar and the difference in arterial pH was associated with a marked fall in standard bicarbonate in the former group. No significant difference of Pco(2) between the two groups was found, and hence no simple relationship exists between hypocapnia and the development of acidaemia in salicylate poisoning. Acidaemia is shown to be associated with impaired consciousness and to carry a grave prognosis.
Comparison of 2 Methods for Calculating Adjusted Survival Curves From Proportional Hazards Models
Authors: William A. Ghali
Journal: JAMA (2001)

ContextAdjusted survival curves are often presented in medical research articles. The most commonly used method for calculating such curves is the mean of covariates method, in which average values of covariates are entered into a proportional hazards regression equation. Use of this method is widespread despite published concerns regarding the validity of resulting curves.ObjectiveTo compare the mean of covariates method to the less widely used corrected group prognosis method in an analysis evaluating survival in patients with and without diabetes. In the latter method, a survival curve is calculated for each level of covariates, after which an average survival curve is calculated as a weighted average of the survival curves for each level of covariates.Design, Setting, and PatientsAnalysis of cohort study data from 11 468 Alberta residents undergoing cardiac catheterization between January 1, 1995, and December 31, 1996.Main Outcome MeasuresCrude and risk-adjusted survival for up to 3 years after cardiac catheterization in patients with vs without diabetes, analyzed by the mean of covariates method vs the corrected group prognosis method.ResultsAccording to the mean of covariates method, adjusted survival at 1044 days was 94.1% and 94.9% for patients with and without diabetes, respectively, with misleading adjusted survival curves that fell above the unadjusted curves. With the corrected group prognosis method, the corresponding survival values were 91.3% and 92.4%, with curves that fell more appropriately between the unadjusted curves.ConclusionsMisleading adjusted survival curves resulted from using the mean of covariates method of analysis for our data. We recommend using the corrected group prognosis method for calculating risk-adjusted curves.
Modulation of Tthy alloantigen expression in the neonatal mouse. The Tthy-bearing thymocyte is a precursor for the peripheral cells expressing Tind and Tsu.
Authors: S K Keesee, F L Owen
Journal: The Journal of Experimental Medicine (1983)

The T cell alloantigen Tthyd appears on a subpopulation of thymocytes in mice bearing the Igh-1d or e heavy chain haplotype. Ontogenetic studies have suggested that this antigen precedes the appearance of two other T cell alloantigens in the same linkage group, Tindd and Tsud. The purpose of this study was to determine if the Tthy-bearing cell is a precursor for cells in the periphery expressing Tind and Tsu. CAL-20 mice were treated at 48-h intervals beginning on the day of birth with a monoclonal antibody recognizing Tthy. Tthy alloantigen expression, monitored by cytotoxicity assays, was found to be significantly depressed in the thymuses of treated animals; Tind and Tsu also failed to appear in the periphery. Treatment with anti-Tthy caused no significant changes in frequency or surface intensity in the expression of surface Ig. Thy-1.2, Thy-1.2, and Lyt-2.2, as studied by cytofluorograph analysis. We conclude that the T-thyd-bearing cells in the thymus represent a subpopulation that may be a precursor for Tindd- and Tsud-bearing cells. However, Tthyd-bearing cells are more mature than the Thy-1.2 common T cell precursor, pre-T.
Mortality in Patients With Hypovolemic Shock Treated With Colloids or Crystalloids—Reply
Authors: Djillali Annane, Sylvie Chevret
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epicardial excitation during ventricular pacing. Relative independence of breakthrough sites from excitation sequence in canine right ventricle.
Authors: G Arisi, E Macchi, C Corradi, R L Lux, B Taccardi
Journal: Circulation Research (1992)

In a previous investigation, epicardial recordings with 1,124 closely spaced electrodes revealed 20-35 breakthrough (BKT) sites and an equal number of separate wave fronts on the ventricular surface of exposed dog hearts during normal sinus rhythm. In the present study we tried 1) to determine whether ventricular pacing also produced multiple BKTs and wave fronts and 2) to determine whether the number and location of BKTs were, to some degree, independent of pacing site. The study mainly focused on right ventricular BKTs observed during right ventricular pacing. To test hypotheses 1 and 2 we identified many breakthrough sites during sinus rhythm in seven exposed dog hearts and then paced the heart from several BKT and non-BKT sites on the right ventricle. Epicardial potential maps and excitation time maps were obtained by using 1,124 epicardial electrodes covering the anterior right ventricle and part of the anterior left ventricle. A primary wave front spread radially for several centimeters from the pacing site, and no BKTs appeared in the areas covered by the primary wave front. In the remaining areas (secondary areas), multiple BKTs appeared; their number was close to that observed during sinus rhythm in the same areas (113 versus 115, respectively, in 12 paced beats). The majority of paced BKTs (83 out of 115, or 72%) occurred exactly at the same locations where they appeared during sinus rhythm. However, 30 right ventricular BKTs observed during sinus rhythm disappeared in the secondary areas and were replaced by approximately the same number of new BKTs. Many areas without BKTs in normal beats remained so in paced beats.(ABSTRACT TRUNCATED AT 250 WORDS)
Biomedical Ethics and the Law
Authors: Walter G. Gunn
Journal: JAMA (1977)

The past decade has seen an eruption of medical controversies that have puzzled physicians and laymen alike, the former because strategies required in their resolution are often outside the sphere of "routine" scientific thinking or model manipulation, the latter because these controversies often involve legal and philosophical concepts that have indistinct frontiers. This new book sketches five of such changing questions with a series of challenging background articles on each. All contributors are authorities in their fields. The subjects include abortion, mental illness, human experimentation, human genetics, and dying. Most of the papers are reprints from philosophical and sociological journals between 1969 and 1973. Their collection here offers a unified compilation of seed materials and a source book for students interested in exploring these topics. The editors provide an admirable selection of articles on the moral, ethical, and scientific background of human experimentation, including the rights of experimental subjects. It
Exercise-induced microvolt T-wave alternans in the congenital long QT syndrome
Authors: Kathryn A. Glatter, Michael J. Ackerman, Gioia Turitto, Nabil El-Sherif, Nitish Badhwar, Richard Hongo, George F. Van Hare, Matti Viitasalo, Melvin M. Scheinman
Journal: Journal of the American College of Cardiology (2002)
Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors
Authors: Scott Kaatz, Peter A. Kouides, David A. Garcia, Alex C. Spyropolous, Mark Crowther, Jim D. Douketis, Anthony K. C. Chan, Andra James, Stephan Moll, Thomas L. Ortel, Elizabeth M. Van Cott, Jack Ansell
Journal: American Journal of Hematology (2012)

The new oral anticoagulants dabigatran, rivaroxaban and apixaban have advantages over warfarin which include no need for laboratory monitoring, less drug-drug interactions and less food-drug interactions. However, there is no established antidote for patients who are bleeding or require emergent surgery and there is a paucity of evidence to guide the clinical care during these situations. Members of thrombosis and anticoagulation groups participating in the Thrombosis and Hemostasis Summit of North America formulated expert opinion guidance for reversing the anticoagulant effect of the new oral anticoagulants and suggest: routine supportive care, activated charcoal if drug ingestion was within a couple of hours, and hemodialysis if feasible for dabigatran. Also, the pros and cons of the possible use of four factor prothrombin complex concentrate are discussed.
The exam scam
Authors: D. K. Sokol
Journal: BMJ (2014)

Medical royal colleges and faculties have a duty to provide a fair and affordable exam appeal process



To the two certainties of death and taxes should be added, for doctors, professional exams.

My client was a registrar undergoing a second attempt at her specialty examinations. If she failed, the prospects of pursuing her specialty were bleak. She duly paid the examination fee of about £1000 (€1300; $1700). Unforeseen circumstances arose in the exam that affected her ability to concentrate. She narrowly failed the exam and appealed the decision. She was invited to appeal to the faculty by paying a fee of £2780. As the saying goes, “In England justice is open to all—like the Ritz.” Still, such was her conviction that she exhausted her savings to pursue the appeal.

Over 400 years ago the precursor to the Royal College of Physicians, the London College of Physicians, imprisoned a Dr Bonham …
Genetic control of specific immune suppression. I. Experimental conditions for the stimulation of suppressor cells by the copolymer L-glutamic acid50-L-tyrosine50 (GT) in nonresponder BALB/c mice.
Authors: P Debré, J A Kapp, B Benacerraf
Journal: The Journal of Experimental Medicine (1975)

In the present studies we have confirmed that the random copolymer of L-glutamic acid50-L-tyrosine50 (GT) fails to induce an antibody response in a large number of inbred strains of mice. Nevertheless, GT complexed to methylated bovine serum albumin (MBSA) elicits a GT-specific IgG PFC response in vivo. Furthermore, injection of BALB/c mice with 10 to 100 mug of GT specifically decreases their ability to develop anti-GT PFC responses to a subsequent challenge with GT-MBSA. GT-specific tolerance can be transferred to normal, syngeneic recipients by spleen cells or thymocytes of GT-primed animals. These results indicate that the stimulation of suppressor cells can be observed in nonresponder mice with another synthetic polypeptide besides GAT. Various parameters of GT-specific immunosuppression in BALB/c mice are described. The application of these techniques to the study of the genetic factors controlling the stimulation of specific immune suppression is discussed.
Abstract 453: Prognostic value of 18F-FDG PET/CT in nasopharyngeal carcinoma
Authors: Ying Huang, WeiWei Xiao, ShengFa Su, Yong Chen, Fei Han, Bin S. Teh, TaiXiang Lu
Journal: Cancer Research (2012)

Abstract Background: To investigate the prognostic value of pretreatment tumor maximal standardized uptake (SUVmax) values of 18F-FDG PET/CT in nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiotherapy (IMRT). Methods: Consecutive biopsy-proven, non-metastatic NPC patients undergoing pretreatment 18F-FDG PET/CT and receiving IMRT from 2002 to 2005 were retrospectively reviewed. SUVmax of primary tumor (SUVmax-T) and regional lymph nodes (SUVmax-N) was measured. Survival was estimated using the Kaplan-Meier method. Prognostic significance was assessed using univariate and multivariate analyses. Results: One hundred sixty-nine eligible patients were enrolled, with 132 male and 37 female. Median age was 42 years. The distribution of stages was 14 for I, 39 for II, 61 for III and 55 for IV. Median SUVmax-T was 4.0 and median SUVmax-N was 3.5. Median follow-up was 71 months. Thirty five patients died and distant metastasis was the main reason of death (71.4%). Among 134 living patients, most patients are disease free (92.6%). In univariate analysis, older age, advanced T stage, advanced N stage, advanced clinical stage, higher SUVmax-T and higher SUVmax-N were all associated with lower OS, DFS and DMFS (Table 1). Remarkably, multivariate analysis found SUVmax-T and SUVmax-N were significant prognostic factors for OS, DFS and DMFS, independent of T and N stage (Table 1). Conclusion: SUVmax-T and SUVmax-N have prognostic value for survivals in IMRT-treated NPC patients. High FDG uptake in primary tumor and regional lymph nodes are useful for the identification of patients at higher risk. Abbreviations: OS, overall survival; DFS, disease-free survival; DMFS, distant metastasis-free survival; uni, univariate analysis; multi, multivariate analysis Table 1. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 453. doi:1538-7445.AM2012-453
Abstract 1857: Intracellular protein GP128 is a novel tumor angiogenesis marker on gastric cancer cell lines and GI tissues: Ectopic expression on the cell surface defined by MS38-2.1 mAb
Authors: Ming Li, XueHua Chen, ShengCe Tao, XiaoLei Zhang, Jue Yin, JianYu Sun, YiPing Zhou, JianPeng Gao, YunCheng Liu, DongQing Zhang, WanBo Li, JingXin Hong, Jeffery E. Lee, BingYa Liu, ZhenQing Feng, Mason Lu
Journal: Cancer Research (2012)

Abstract Our aim is to generate monoclonal antibodies (mAbs) against novel markers on the cancer cell surface using an innovated high throughput screening (HTS) strategy. Mixed live cells from four gastric cancer cell lines (MKN45, SGC7901, BGC823 and MKN28) were used as the immunogen for A/J mice: spleen cells were then fused with mouse SP2/0 myeloma cells to generate monoclonal antibody hybridomas. The 16 highly positive hybridoma colonies were selected from 20,000 colonies in sixty-seven 96-well plates through screening using live cell (gastric cancer cells versus normal PBMC) staining and FACS-HTS technology. Protein-A affinity purified mAbs were used to define the antigens, which were confirmed as novel biomarkers on the cancer cell surface using microarray, mass and proteomic analyses. Protein microarray analysis with the MS38-2.1 mAb identified an intracellular protein GP128 (e.g., SPRR3) as the most likely a novel cancer biomarker. The immunohistochemical profiles of MS38-2.1 mAb in GI (gastric and colorectal) cancer tissues were found to be significantly higher (P&amp;lt;0.01) than those in normal GI tissues, and confirmed to be restricted to the small- and medium-sized blood vessels and the cancer cells. Human SPRR3 belongs to a family of small proline-rich repeat proteins that is normally expressed intracellularly. Our findings demonstrate that GP128, like SPRR3, could be ectopically expressed in the extracellular matrix in GI cancers. Conclusion: Our results demonstrate that the intracellular protein GP128 might play a role in gastrointestinal cancer development. This investigation also provides an example of identification of potential cancer biomarkers through a novel screening technique. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1857. doi:1538-7445.AM2012-1857
NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun
Authors: Hailing Liu, Chau R. Lo, Mark J. Czaja
Journal: Hepatology (2002)

Hepatocyte resistance to tumor necrosis factor α (TNF)-induced apoptosis is dependent on activation of the transcription factor nuclear factor κB (NF-κB). To determine the mechanism by which NF-κB protects against TNF toxicity, the effect of NF-κB inactivation on the proapoptotic c-Jun NH 2 -terminal kinase (JNK) signaling pathway was examined in the rat hepatocyte cell line RALA255-10G. Adenovirus-mediated NF-κB inactivation led to a prolonged activation of JNK and increased activating protein-1 (AP-1) transcriptional activity in response to TNF treatment. Inhibition of the function of the JNK substrate and AP-1 subunit c-Jun blocked cell death from NF-κB inactivation and TNF as determined by measures of cell survival, numbers of apoptotic and necrotic cells, and DNA hypoploidy. Inhibition of c-Jun function blocked mitochondrial cytochrome c release and activation of caspase-3 and -7. NF-κB therefore blocks the TNF death pathway through down-regulation of JNK and c-Jun/AP-1. In conclusion, sustained JNK activation that occurs in the absence of NF-κB initiates apoptosis through a c-Jun-dependent induction of the mitochondrial death pathway.
With HMOs—Well, Who Really Knows?
Authors: Deborah Smith Parker
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal