Autoimmune Neutropenia, Hemolytic Anemia, and Reticulocytopenia in Hodgkin's Disease
Authors: Alan B. Weitberg, David C. Harmon
Journal: Annals of Internal Medicine (1984)

Brief Reports1 May 1984Autoimmune Neutropenia, Hemolytic Anemia, and Reticulocytopenia in Hodgkin's DiseaseALAN B. WEITBERG, M.D., DAVID C. HARMON, M.D.ALAN B. WEITBERG, M.D.Search for more papers by this author, DAVID C. HARMON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-5-702 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVarious immunologic abnormalities have been described in patients with Hodgkin's disease, including autoimmune hemolytic anemia and immune thrombocytopenia (1-3). Autoimmune neutropenia, however, has only recently been documented in a patient with Hodgkin's disease (4). In this report, we describe the case of a patient who had autoimmune neutropenia, hemolytic anemia, and reticulocytopenia as the initial manifestations of a relapse of Hodgkin's disease.A 26-year-old man was transferred to the Massachusetts General Hospital with anemia, leukopenia, and fever. Eight years earlier, he had been treated with MOPP chemotherapy (mechlorethamine, vincristine, procarbazine, and prednisone) and maintenance vinblastine for stage IIIB Hodgkin's disease....References1. EISNER E, LEY A, and MAYER K. Coombs'-positive hemolytic anemia in Hodgkin's disease. Ann Intern Med. 1967;66:258-73. LinkGoogle Scholar2. JONES S. Autoimmune disorders and malignant lymphoma. Cancer. 1973;31:1092-8. CrossrefMedlineGoogle Scholar3. WADDELL C and CINO P. Immune thrombocytopenic purpura occurring in Hodgkin's disease after splenectomy: report of two cases and a review of the literature. Am J Hematol. 1979;7:381-7. CrossrefMedlineGoogle Scholar4. HUNTER J, LOGUE G, and JOYNER J. Autoimmune neutropenia in Hodgkin's disease: a case report [Abstract]. Clin Res. 1981;29:336A. Google Scholar5. HARMON D, WEITZMAN S, and STOSSEL T. A staphylococcal slide test for detection of antineutrophil antibodies. Blood. 1980;56:64-9. CrossrefMedlineGoogle Scholar6. HARMON D, WEITZMAN S, and STOSSEL T. The clinical spectrum of autoimmune neutropenia is determined by the selectivity of anti-neutrophil antibodies [Abstract]. Blood. 1981;58(suppl):89A. Google Scholar7. LEVINE A, THORNTON P, and FORMAN S. Positive Coombs test in Hodgkin's disease: significance and implications. Blood. 1980;55:607-10. CrossrefMedlineGoogle Scholar8. KRUSKALL M, WEITZMAN S, STOSSEL T, HARRIS N, and ROBINSON S. Lymphoma with autoimmune neutropenia and hepatic sinusoidal infiltration: a syndrome. Ann Intern Med. 1982;97:202-5. LinkGoogle Scholar9. GARRATTY G, PETZ L, WALLERSTEIN R, and FUDENBERG H. Autoimmune hemolytic anemia in Hodgkin's disease associated with anti-It. Transfusion. 1974;14:226-31. CrossrefMedlineGoogle Scholar10. MOORE J and LOGUE G. I and i antigens on normal and leukemic leukocytyes. Cancer. 1978;42:140-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALAN B. WEITBERG, M.D.; DAVID C. HARMON, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIf at first you don't succeed: Try, try againParaneoplastic autoimmune cytopenias in Hodgkin lymphomaClassification and Clinical Characteristics of Autoimmune Hemolytic AnemiasManagement of Autoimmune Hemolytic AnemiasThe Dual Association between Lymphoma and AutoimmunityAutoantibodies, Autoimmunity and CancerIMMUNE THROMBOCYTOPENIA AND HEMOLYTIC ANEMIA AS A PRESENTING MANIFESTATION OF HODGKIN DISEASELeukopenia, thrombocytopenia, and acute autoimmune hemolytic anemia associated with an unusual (type 2/4) Hodgkin's disease: Case reportImmune Thrombocytopenia and Hemolytic Anemia Associated with Hodgkin DiseaseProspective Evaluation of the Chemiluminescence Test for the Detection of Granulocyte Antibodies: Comparison with the Granulocyte Immunofluorescence TestHematologic manifestations of malignancyAutoimmune Phenomena in Lymphoid MalignanciesIdiopathic thrombocytopenic purpura and autoimmune hemolytic anemia in Hodgkin's diseaseAutoimmune neutropenia and Hodgkin's diseaseAUTOIMMUNITY TO INSULIN RECEPTOR AND HYPOGLYCAEMIA IN PATIENT WITH HODGKIN'S DISEASEAutoimmune thrombocytopenia and neutropenia after remission induction therapy for acute leukaemiaThrombocytopenic purpura as first manifestation of an inapparent Hodgkin's diseaseImmune Hemolytic Anemia in the AgedErythema nodosum heralding recurrent Hodgkin's disease 1 May 1984Volume 100, Issue 5Page: 702-703KeywordsChemotherapyFellowshipsFeversHematology and oncologyHemolytic anemiaHodgkin lymphomaIdiopathic thrombocytopenic purpuraMechlorethamineNeutropeniaProcarbazine ePublished: 1 December 2008 Issue Published: 1 May 1984 PDF downloadLoading ...