tbuckley/cabot-search huggingface dataset:
Conditional <i>Dicer</i> Gene Deletion in the Postnatal Myocardium Provokes Spontaneous Cardiac Remodeling
Authors: Paula A. da Costa Martins, Meriem Bourajjaj, Monika Gladka, Mara Kortland, Ralph J. van Oort, Yigal M. Pinto, Jeffery D. Molkentin, Leon J. De Windt
Journal: Circulation (2008)

Dicer, an RNAse III endonuclease critical for processing of pre-microRNAs (miRNAs) into mature 22-nucleotide miRNAs, has proven a useful target to dissect the significance of miRNAs biogenesis in mammalian biology.To circumvent the embryonic lethality associated with germline null mutations for Dicer, we triggered conditional Dicer loss through the use of a tamoxifen-inducible Cre recombinase in the postnatal murine myocardium. Targeted Dicer deletion in 3-week-old mice provoked premature death within 1 week accompanied by mild ventricular remodeling and dramatic atrial enlargement. In the adult myocardium, loss of Dicer induced rapid and dramatic biventricular enlargement, accompanied by myocyte hypertrophy, myofiber disarray, ventricular fibrosis, and strong induction of fetal gene transcripts. Comparative miRNA profiling revealed a set of miRNAs that imply causality between miRNA depletion and spontaneous cardiac remodeling.Overall, these results indicate that modifications in miRNA biogenesis affect both juvenile and adult myocardial morphology and function.
Erythropoietic protoporphyria and iron therapy
Authors: B.M. McClements, Ann Bingham, M.E. Callender, Elisabeth R. Trimble
Journal: British Journal of Dermatology (1990)

Journal Article Erythropoietic protoporphyria and iron therapy Get access B.M. McClements, B.M. McClements Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland Search for other works by this author on: Oxford Academic Google Scholar Ann Bingham, Ann Bingham Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland Search for other works by this author on: Oxford Academic Google Scholar M.E. Callender, M.E. Callender Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland Search for other works by this author on: Oxford Academic Google Scholar Elisabeth R. Trimble Elisabeth R. Trimble Department of Chemical Pathology, The Queen's University of Belfast Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 122, Issue 3, 1 March 1990, Pages 423–424, https://doi.org/10.1111/j.1365-2133.1990.tb08293.x Published: 01 March 1990
Alternative therapies could save the NHS money, says report commissioned by Prince Charles
Authors: Roger Dobson
Journal: BMJ (2005)

Many complementary treatments could make an important contribution to health care in the United Kingdom, says a report commissioned by the Prince of Wales and published this week.

Greater use of some complementary treatments could result in major savings in healthcare costs too, says the report, which calls for the National Institute for Health and Clinical Excellence to assess the cost effectiveness of such treatments.

“Despite …
Bevacizumab (BV) maintenance therapy significantly delays disease progression (PD) or death compared with placebo (PL) in the AVADO trial (BV + docetaxel [D] vs D + PL in 1st-line HER2-negative locally recurrent [LR] or metastatic breast cancer [mBC]).
Authors: P Fumoleau, R Greil, D Rayson, V Müller, S Barni, E Aleknavicius, E Tellez, C Wilson, DW Miles
Journal: Cancer Research (2009)

Abstract Abstract #903 Background: BV (Avastin®) is a monoclonal antibody to VEGF that significantly improved PFS and response rate when combined with 1st-line taxane chemotherapy (CTx) in two randomised phase III studies in patients (pts) with LR or mBC: E2100 (weekly paclitaxel ± BV) and double-blind, PL-controlled study AVADO (D ± two different BV doses). Preclinical data suggest that BV inhibits tumour neovascularisation and can limit tumour vascular regrowth. Both above trial protocols recommended BV use until PD, even after discontinuation of concomitant CTx. In the NO16966 trial in metastatic colorectal cancer, PFS was longer for pts continuing BV following cessation of CTx than for those where BV and CTx were stopped at the same time. We report results of an exploratory analysis of time to PD or death after cessation of D in pts in AVADO.&amp;#x2028; Methods: AVADO compared BV 7.5 or 15mg/kg + D 100mg/m2 with PL + D in 736 pts with inoperable LR or mBC, ECOG PS 0–1 and adequate LVEF. D and BV/PL were administered q3w, with D given for up to 9 cycles and BV/PL continued until PD or unacceptable toxicity.&amp;#x2028; Results: The table presents median time from discontinuation of D until PD or death in different subgroups in the AVADO study. Approximately 70% of pts in each arm discontinuing D went on to receive at least one dose of BV or PL before PD.&amp;#x2028; &amp;#x2028; Conclusions: Continuation of single-agent BV at either dose after discontinuation of D significantly delayed PD or death compared with single-agent PL. These results support the hypothesis that BV may inhibit tumour neovascularisation and progression following CTx and suggests that clinical benefit may be maximised by treatment with BV until progression. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 903.
Fatal Tetanus After Prophylaxis With Human Tetanus Immune Globulin
Authors: David M. Johnson
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Prophylaxis of tetanus is best accomplished by active immunization with tetanus toxoid. In the unimmunized, prophylaxis can be passively accomplished with human tetanus immune globulin. The recommended dose of human tetanus immune globulin is 250 units given intramuscularly at the time of the injury.<sup>1</sup>To our knowledge, there have been no reports of tetanus after prompt administration of human tetanus immune globulin, in the recommended dosage. We report a case of tetanus following prompt administration of 250 units of human tetanus immune globulin. <h3>Report of a Case:—</h3> A 45-year-old white man dropped a railroad tie on his left hand. That day, the patient's physician sutured the wound and gave him 250 units of tetanus immune globulin intramuscularly. There was no history of active immunization for tetanus, prior injury, or past military service. Three days later gangrene developed in the fourth finger of the left hand and
Intrauterine Devices Are Safe and Effective Contraceptives for Type I Diabetic Women: Further evidence
Authors: Renate Kimmerle, Lutz Heinemann, Michael Berger
Journal: Diabetes Care (1995)

IUDs provide safe and effective contraception for type I diabetic women.  Two prospective controlled trials with state-of-the-art copper IUDs in type I diabetic women have shown that IUDs are as safe and effective as in nondiabetic women.  There remains however a widespread belief among physicians that diabetic women are at higher risk of IUD-associated pelvic inflammatory disease (PID).  The authors report their findings from the evaluation of the use of IUDs among 808 women of mean age 31 years having diabetes for a mean period of 14 years.  94 current users of mean age 32 years (range 20-45 years) were identified.  70% were nullipara who had used the IUD for an average of 5 years (range 0.1-20 years).  Nine of these women were less than satisfied with IUD use due to their experience with IUD-associated pain and/or bleeding.  There were also 33 ex-users who had used the IUD for a mean 6 years.  This study found a 0.3 rate of accidental pregnancy per 100 person-years a 0.5 rate of PID and a 3.4 rate of pain and/or bleeding results well within the corresponding rates seen in large prospective studies of modern copper IUD use among nondiabetic women.
Fluid Replacement for Severe Hyponatremia
Authors: Michael L. Moritz
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FDA Seeks Comments on How to Enhance Food Safety
Authors: Stuart L. Nightingale
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interrelationships Between Cardiac Effects of Ouabain, Hypocalcemia and Hyperkalemia
Authors: ERNEST PAGE, JACK D. REAL
Journal: Circulation Research (1955)

In dogs anesthetized with pentobarbital, ventricular arrhythmias induced by ouabain were consistently reverted to sinus rhythm by acute lowering of the serum calcium. In ouabain-in-toxicated dogs, the depressed and shortened S-T segment was elevated and lengthened by induced hypocalcemia. Potassium administered concomitantly with ouabain exerted a protective effect against ouabain intoxication. Lowering of the serum calcium in animals showing moderately advanced potassium effects in their ECG precipitated acute, fatal potassium poisoning. Ouabain was capable of reversing the tachycardia and pulsus alternans due to hypocalcemia in the face of persistent hypocalcemic tetany.
Integrity in Scientific Research: Creating an Environment that Promotes Responsible Conduct
Authors: K. Okkenhaug
Journal: BMJ (2003)

Integrity (or lack of it) in scientific research is a hot topic, and getting hotter. A number of high profile cases of scientific misconduct in the medical press have put scientific research practices under the spotlight. Such cases reflect badly on the scientific community, undermine the public's trust in scientific progress, and jeopardise future funding for research. And it's not just a scientist's problem: patients suffer when they take part in badly designed clinical trials or are excluded from important new treatments that are delayed because of false promises based on …
The Use of Hypofractionated Whole Breast Irradiation in Treatment of Patients With Early-Stage Breast Cancer in the United States
Authors: Timur Mitin, Charlotte Dai Kubicky
Journal: JAMA Oncology (2015)

RESULTS Hypofractionated WBI increased from 10.6% (95% CI, 8.8%-12.5%) in 2008 to 34.5% (95% CI, 32.2%-36.8%) in 2013 in the hypofractionation-endorsed cohort and from 8.1% (95% CI, 6.0%-10.2%) in 2008 to 21.2% (95% CI, 18.9%-23.6%) in 2013 in the hypofractionation-permitted cohort. Adjusted mean total health care expenditures in the 1 year after diagnosis were $28 747 for hypofractionated and $31 641 for conventional WBI in the hypofractionationendorsed cohort (difference, $2894; 95% CI, $1610-$4234; P < .001) and $64 273 for hypofractionated and $72 860 for conventional WBI in the hypofractionation-permitted cohort (difference, $8587; 95% CI, $5316-$12 017; P < .001). Adjusted mean total 1-year patient out-of-pocket expenses were not significantly different between hypofractionated vs conventional WBI in either cohort.
EXPERIMENTAL HYPERGAMMAGLOBULINEMIA IN MINK
Authors: James B. Henson, John R. Gorham, Robert W. Leader, Bernard M. Wagner
Journal: The Journal of Experimental Medicine (1962)

Hypergammaglobulinemia in mink was produced by the injection of crude tissue suspensions from mink with spontaneous Aleutian disease. The initiating factor was found to be resistant to 0.3 per cent formalin for 2 weeks but not 40 weeks at 5°C. Foreign antigens as well as formalinized normal mink tissue from homologous and heterologous genotypes did not cause a detectable change in the serum protein values. Mink homozygous recessive for the Aleutian gene were found to be significantly more susceptible to the experimental disease. Possible pathogenetic mechanisms as well as similarities between the mink disease and certain immunologic and connective tissue diseases of man are discussed.
Metabolic effects of vanadyl sulfate in humans with non—insulin-dependent diabetes mellitus: In vivo and in vitro studies
Authors: Allison B. Goldfine, Mary-Elizabeth Patti, Lubna Zuberi, Barry J. Goldstein, Raeann LeBlanc, Edwin J. Landaker, Zhen Y. Jiang, Gail R. Willsky, C. Ronald Kahn
Journal: Metabolism (2000)
S80. Prolongation of T cell response by OX40 co-signalling CARS
Authors: H Abken
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Adoptive therapy of cancer with genetically redirected T cells showed spectacular efficacy in recent trials. A body of pre-clinical and clinical data indicate that young effector and central memory T cells perform superior in a primary anti-tumor response; repetitive antigen
Die menschliche Leber im Elektronenmikroskop: Untersuchungen an Leberpunktaten
Authors: Robert J. Stein
Journal: JAMA (1965)

During the past few years, numerous publications appeared describing the ultrastructure of animal and human livers. Also in the past two or three years, a number of excellent monographs were published dealing with the same subject. The publication of Cossel's monograph at this time only supplements the information already available; however, his extensive use of human material, normal and pathologic, places this volume in a class by itself. The electron micrographs are of good quality and the three dimensional drawings are excellent.  The volume contains 599 references which include almost all of the major publications in the field of hepatic ultrastructure.  It is only fair to point out that this book is not without certain imaginative concepts which have insufficient scientific basis. Cossel's description of mitochondrial changes and their relation to hepatic pathology and formation of new mitochondria by division of preexisting mitochondria lacks adequate experimental proof. It also should
Magnetic resonance imaging [MRI] or transesopha-geal echo [TEE] for anatomical mapping of thoracic aortic dissection?
Authors: Christoph A. Nienaber, Rolf Spielmann, Yskort v. Kodolitsch, Volker Siglow, Tilman Jaup, Walter Bleifeld
Journal: Journal of the American College of Cardiology (1991)
Relation of fingerprints and shape of the palm to fetal growth and adult blood pressure.
Authors: K M Godfrey, D J Barker, J Peace, J Cloke, C Osmond
Journal: BMJ (1993)

To examine how finger and palm prints are related to fetal growth and adult blood pressure.Follow up study of babies born around 50 years ago whose birth weight, placental weight, head circumference, and length at birth were recorded.Preston, Lancashire.139 men and women born in Sharoe Green Hospital in Preston during 1935-43 and still living in Lancashire.Finger and palm prints and current blood pressure.People who were thin at birth had more whorl patterns on their fingers. People who were short at birth in relation to their head circumference had longer hands and a narrower palmer angle. Mean systolic blood pressure was 8 mmHg higher (95% confidence interval 2 to 13; p = 0.01) in the 93 men and women with a whorl pattern on one or more fingers compared with the 46 who had no whorls. The greater the number of fingers with whorls the higher the systolic blood pressure. Whorls on the right hand were more strongly associated with higher systolic pressure than whorls on the left, mean systolic pressure rising by 2.2 mmHg (0.2 to 4.1; p = 0.03) for each additional whorl on the right hand. People with long hands and a narrow palmar angle also had higher systolic pressure. Again, these associations were stronger for the right hand. Mean systolic pressure rose by 0.49 mmHg (-0.03 to 1.01; p = 0.03) for each degree decrease in palmar angle on the right hand.Fingertip whorls and a narrow palmar angle are indelible markers of impaired fetal development at different stages in pregnancy. Both are associated with raised blood pressure in adult life.
Abstract PD01-02: Integration of Capecitabine into Anthracycline-and Taxane-Based Adjuvant Therapy for Triple-Negative Early Breast Cancer: Final Subgroup Analysis of the FinXX Study
Authors: H Lindman, P-L Kellokumpu-Lehtinen, R Huovinen, A Jukkola-Vuorinen, M Tanner, R Kokko, J Ahlgren, P Auvinen, P Bono, H Joensuu
Journal: Cancer Research (2010)

Abstract Background: Standard adjuvant chemotherapy regimens for patients with moderate-to-high risk early breast cancer typically contain a taxane, an anthracycline and cyclophosphamide. The randomised, phase III FinXX study aimed to investigate whether the integration of capecitabine into such a regimen enhances outcome. Here we present final 5-year exploratory analyses from the subgroup of patients with triple-negative early breast cancer (TNBC). Methods: Patients aged 18-65 years, with histologically confirmed invasive node positive breast cancer or node negative progesterone receptor negative breast cancer &amp;gt; 20 mm, and with a WHO performance status of 0 or 1, with no previous neoadjuvant chemotherapy were randomised. Patients received 3 x XT (capecitabine 900mg/m2 bid d1-15 + docetaxel 60mg/m2 d1)≥3 x CEX (cyclophosphamide 600mg/m2 d1, + epirubicin 75mg/m2 d1 + X 900mg/m2 bid d1-15, q3w) or 3 x T (80mg/m2 d1)≥3 x CEF (C 600mg/m2 d1, E 75mg/m2 d1, 5-FU 600mg/m2 d1, q3w). The primary endpoint was RFS, defined as the time from randomisation to the first time the patient is recorded as having disease recurrence or the date of death if the patient dies due to causes other than disease recurrence. Secondary endpoints included overall survival and safety. Results: Between January 2004 and May 2007, 1,500 women from Finland and Sweden were randomised (XT→CEX n=753, T→CEF n=747). Of these, 202 patients (13.5%) had TNBC (XT→CEX n=93, T→CEF n=109). After a median follow-up of 59 months, RFS was significantly improved in the TNBC XT→CEX arm versus control (HR 0.48, 95% CI 0.26-0.88; p=0.018). The following endpoints were also significant: 5-year RFS in patients with TNBC versus those without TNBC (HR 0.50, 95% CI 0.36-0.69; P&amp;lt;0.001); 5-year distant disease-free survival in TNBC patients receiving XT→CEX versus control (HR 0.51, p=0.035); overall survival in TNBC patients receiving XT→CEX versus control (HR 0.42, p=0.019). Conclusions: The FinXX trial is the first to report the efficacy of capecitabine in combination with anthracycline-/taxane-containing therapy in the adjuvant treatment of early breast cancer. The exploratory subgroup analysis shows that XT→CEX is more effective than T→CEF in triple-negative BC, a population with a high unmet need; XT→CEX versus control resulted in a significant improvement in RFS and OS after 5 years. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr PD01-02.
Directory Lists Overseas Service Opportunities for Physician Volunteers; Possible Factors Outlined for Consideration in Making Decision
Authors: Phil Gunby
Journal: JAMA (1987)

THE DIRECTORY on the following nine pages lists more than 100 organizations that offer US physicians long-term (abbreviated 1-t) and short-term (s-t) service opportunities overseas. (One other abbreviation used in some of the columns is y, for yes.) It was compiled in cooperation with the American Medical Association's Physicians' Placement Service, Division of Practice Development Services. Listing does not imply endorsement by the American Medical Association. Because an effort such as this cannot hope to include all overseas service opportunities for physicians, officials of any organization that might be listed in the future may supply the necessary information (using the directory on the following pages as a guide) to the AMA's Physicians' Placement Service, 535 N Dearborn St, Chicago, IL 60610. Physicians who find opportunities of interest in the following pages are reminded that—as with the 1984 directory—there are many related aspects to consider. Among these considerations are the following:
Pathophysiological role of changing atrial size and pressure in modulation of atrial natriuretic factor during evolving experimental heart failure
Authors: G. W Moe, C. Angus, R. J Howard, A. J De Bold, P. W Armstrong
Journal: Cardiovascular Research (1990)

Journal Article Pathophysiological role of changing atrial size and pressure in modulation of atrial natriuretic factor during evolving experimental heart failure Get access Gordon W Moe, Gordon W Moe Division of Cardiology, Department of Medicine, St Michael's Hospital, University of Toronto, 30 Bond St, Toronto, Ontario, Canada M5B1W8 Correspondence to: Dr Moe Search for other works by this author on: Oxford Academic PubMed Google Scholar Carmella Angus, Carmella Angus Division of Cardiology, Department of Medicine, St Michael's Hospital, University of Toronto, 30 Bond St, Toronto, Ontario, Canada M5B1W8 Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J Howard, Robert J Howard Division of Cardiology, Department of Medicine, St Michael's Hospital, University of Toronto, 30 Bond St, Toronto, Ontario, Canada M5B1W8 Search for other works by this author on: Oxford Academic PubMed Google Scholar Adolfo J De Bold, Adolfo J De Bold Division of Cardiology, Department of Medicine, St Michael's Hospital, University of Toronto, 30 Bond St, Toronto, Ontario, Canada M5B1W8 Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul W Armstrong Paul W Armstrong Division of Cardiology, Department of Medicine, St Michael's Hospital, University of Toronto, 30 Bond St, Toronto, Ontario, Canada M5B1W8 Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 7, July 1990, Pages 570–577, https://doi.org/10.1093/cvr/24.7.570 Published: 01 July 1990 Article history Received: 24 July 1989 Accepted: 08 March 1990 Published: 01 July 1990