tbuckley/cabot-search huggingface dataset:
Quantitative analysis of pulmonary vascular disease in complete transposition of the great arteries.
Authors: S Yamaki, F Tezuka
Journal: Circulation (1976)

Forty autopsy cases of complete transposition of the great arteries (TGA) and 22 autopsy cases of ventricular septal defect (VSD) were analyzed histologically for evidence of vascular damage due to pulmonary vascular disease (PVD). Positive correlations were generally observed between an index of pulmonary vascular disease (IPVD) and blood pressure of pulmonary circulation. No significant difference in IPVD was found between TGA and VSD in the first five months of life, when cases of each disease were compared at similar blood pressure levels. After that age, however, IPVD was much higher in TGA, and particularly severe PVD in this disease was demonstrated histologically. Morphometrical analysis of the pulmonary artery revealed hypertrophy of the muscular cost in response to elevated blood pressure. However, the progress of medial hypertrophy was retarded in TGA in the first five months, and medial thickness in arteries of cases of TGA older than five months was only 70% of that in VSD at the same blood pressure levels. Suppression of this process of reinforcement of the arterial wall in response to the stress of high pulmonary pressure was regarded as one of the important factors precipitating severe pulmonary vascular disease in transposition of the great arteries.
Inflammation-induced expression of sialyl Lewis X-containing glycan structures on alpha 1-acid glycoprotein (orosomucoid) in human sera.
Authors: T W De Graaf, M E Van der Stelt, M G Anbergen, W van Dijk
Journal: The Journal of Experimental Medicine (1993)

The glycosylation of the acute phase glycoprotein alpha 1-acid glycoprotein (AGP) in human sera is subject to marked changes during acute inflammation as a result of the cytokine-induced hepatic acute phase reaction. The changes described thus far comprise alterations in the type of branching of the carbohydrate structures as revealed by increased reactivity of AGP with concanavalin A. We now report on acute inflammation-induced increases in alpha 1--&amp;gt;3-fucosylated AGP molecules, as detected by the reactivity of AGP towards the fucose-binding Aleuria aurantia lectin (AAL) in crossed affino-immunoelectrophoresis of human sera. Laparotomy of women, for the removal of benign tumors of the uterus, was used as a model for the development of the hepatic acute phase response. Hugh increases were detected in the amounts of strongly AAL-reactive fractions of AGP, presumably containing three or more fucosylated N-acetyllactosamine units. At least part of these Lewis X-type glycans (Gal beta 1--&amp;gt;[Fuc alpha 1--&amp;gt;3]GlcNAc-R) appeared to be substituted also with an alpha 2--&amp;gt;3-linked sialic acid residue. This was revealed by the laparotomy-induced abundant staining of AGP with an antisialyl Lewis X monoclonal antibody (CSLEX-1) on blots of sodium dodecyl sulfate-polyacrylamide gels containing AGP isolated from the sera of a patient at various days after operation. It is concluded that acute inflammation induces a strong increase in sialyl Lewis X-substituted AGP molecules that persists at a high level throughout the inflammatory period. We postulate that these changes represent a physiological feedback response on the interaction between leukocytes and inflamed endothelium, which is mediated via sialylated Lewis X structures and the selectin endothelial-leukocyte adhesion molecule 1.
P72 Liver transplantation for familial amyloidosis; long-term data from the Familial Amyloid Polyneuropathy World Transplant Registry (FAPWTR)
Authors: A. Stangou, H. Wilczek, M. Larsson, O. Suhr, None Bo-G Ericzon
Journal: Gut (2011)

<h3>Introduction</h3> Liver transplantation (LT) is the only available treatment for familial amyloid polyneuropathy (FAP). The Familial Amyloid Polyneuropathy World Transplant Registry (FAPWTR), established shortly after LT was introduced as potential treatment for FAP in 1990, is a centralised service based in Karolinska Institute in Sweden for the collection, monitoring and analysis of international data on LT for FAP. <h3>Aim</h3> We present here the long-term FAPWTR results on the 20 years anniversary of LT for FAP. <h3>Results</h3> Between April 1990 and January 2010, data on 1782 liver transplant procedures and regular follow-up were reported to the FAP registry from 70 transplant centres in 18 countries. Annual international transplant activity for FAP has remained stable at 80–120 procedures since 1996. Among those 866 liver transplants were performed in Portugal, 216 in France, 130 in Sweden, followed by USA 79, UK 78, Brazil 77, Spain 74, Japan 65. The Mediterranean Val30Met transthyretin (TTR) mutation was identified in 83% of cases. A further 50 different variants were reported, collectively referred to as non-ValMet30, and additionally a dozen of non-TTR mutations such as Glu526Val and ApoA1 Gly26Arg. The Ser77Tyr and Thr60Ala mutations appear to be the commonest among non-Val30Met variants. Median age at LT was 38 years (range 21–72 years), 57% of patients were male. Median disease duration prior to transplantation was 3 years (range 0–30 years). Of patients in the Val30Met group 98% received isolated LT, while 11% of non-Val30Met cases required either simultaneous (9%) or sequential heart and liver transplant (2%). Overall 1-, 3-, 5-, and 10-year survival after LT in the entire FAP population including all variants was 86.9%, 81.8%, 77.6% and 71%. Five-year and 10-year survival in the Val30Met group was 80.9% and 73.4% respectively, significantly superior to 57.8% and 43.9% in the non-Val30Met group (p&lt;0.001). Commonest cause of death was cardiac related events (24%), followed by sepsis (23%) or liver related complications (14%). Disease duration prior to transplantation, initial presentation with autonomic rather than peripheral neuropathy, TTR mutation, and modified body mass index (mBMI) of &lt;600, indicating poor nutritional status, were identified as significant factors influencing survival after LT (p&lt;0.01). <h3>Conclusion</h3> Liver transplantation is rational and effective treatment for FAP with excellent long-term outcomes and 10-year survival &gt;70%. Type of mutation, nutritional status, disease duration and degree of autonomic involvement are significant prognostic factors.
Enhanced cholinergic cutaneous vasodilation in Raynaud's phenomenon.
Authors: F Khan, J D Coffman
Journal: Circulation (1994)

Vasodilator function was determined in patients with Raynaud's phenomenon during intra-arterial infusions of the endothelium-dependent and -independent vasodilators, methacholine and sodium nitroprusside, respectively. Reactive hyperemia, induced by 5 minutes of arterial occlusion with exercise, was also measured.Total blood flow was measured in the fingertip and forearm by venous occlusion plethysmography, and blood flow in the forearm skin was determined with laser Doppler flowmetry. Basal fingertip blood flow was not significantly different between control subjects and patients with Raynaud's phenomenon. Infusions of methacholine had no significant effect on fingertip blood flow in control subjects, whereas patients with Raynaud's phenomenon showed a significant increase in fingertip blood flow. Basal total forearm blood flow was significantly lower in patients with Raynaud's phenomenon than in control subjects. Infusions of methacholine and sodium nitroprusside produced dose-related increases in total forearm blood flow that were of similar magnitudes in the two groups, as were the reactive hyperemic responses. Laser Doppler measurements of forearm skin blood flow, however, showed a significantly greater vasodilator response to methacholine in patients with Raynaud's phenomenon than in control subjects. Infusions of sodium nitroprusside produced a relatively small vasodilator response in the skin of the forearm that was smaller than that to methacholine and not significantly different between the two groups.In Raynaud's phenomenon, a greater vasodilator response to infusions of methacholine in the fingertip, where changes in blood flow mainly reflect those of skin, and in the skin of the forearm may reflect increased responsiveness of cutaneous blood vessels to stimulation of the endothelium. The mechanism involved is unclear but may result from a general abnormality of blood vessels in the skin, which is related to the pathophysiology of cutaneous vasospasm.
Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion
Authors: Ghassan Mouneimne, Scott D. Hansen, Laura M. Selfors, Lara Petrak, Michele M. Hickey, Lisa L. Gallegos, Kaylene J. Simpson, James Lim, Frank B. Gertler, John H. Hartwig, R. Dyche Mullins, Joan S. Brugge
Journal: Cancer Cell (2012)
GP is suspended for failing to tell partners about insolvency
Authors: C. Dyer
Journal: BMJ (2010)

A former deputy chairman of the Scottish BMA’s GPs committee, whose financial affairs were in such a “dire state” that he was made insolvent, has been suspended for one month by the General Medical Council for dishonesty.

Stuart Scott, a GP from Aberdeen, has also been suspended from his part time role as clinical director of health and informatics at NHS Grampian.

The UK regulator held that Dr Scott was dishonest in failing to tell his partners at the Holburn practice in Aberdeen that he was insolvent after an order for sequestration of …
TCT-642 Association between Glycemic Variability and Coronary Tissue Characteristics in Patients with Acute Coronary Syndromes
Authors: Kozo Okada, Kiyoshi Hibi, Yasuhiro Honda, Masaomi Gobara, Shunsuke Kataoka, Toshiaki Ebina, Masami Kosuge, Yoshio Tahara, Kengo Tsukahara, Nobuhiko Maejima, Noriaki Iwahashi, Masaaki Konishi, Yasushi Matsuzawa, Eiichi Akiyama, Naoki Nakayama, Zenko Nagashima, Hiroyuki Suzuki, Satoshi Umemura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2013)
Cholesterogenesis, lipogenesis, cholesterol degradation to bile acids, and histopathology of the liver in LA/N-cp obese rats
Authors: M Somanchi, P Ghosh, R S Redman, M R Lakshman
Journal: Hepatology (1997)

Various lipid parameters were determined in lean control and LA/NIH-corpulent (LA/N-cp) rats, a normotensive strain showing metabolic characteristics associated with human Type IV hyperlipidemia. Hepatic and plasma total cholesterol, high density lipoproteins (HDL) cholesterol and triglycerides were significantly higher in the obese group than in the control group. Depending upon whether the data were expressed as per gram tissue or per organ, the rates of de novo fatty acid synthesis in the liver and adipose tissue were higher by 61% to 127% ( P &lt; .05) and 79% to 355% ( P &lt; .05), respectively, in the obese group compared with the lean control group. Similarly, hepatic rate of cholesterol synthesis was higher by 46% to 107% ( P &lt; .05) in the obese animals compared with the lean ones. In vivo hepatic rate of HDL 2 cholesterol degradation to bile acids was lower in the obese group by 48% to 63% ( P &lt; .05). This was confirmed in the perfused liver in spite of the fact that cholesterol uptake from HDL 2 was 3- to 4-fold higher in the obese group. These changes in lipid parameters of the obese animals were neither caused by hyperphagia because they were pair-fed with the control group nor caused by increased rate of food consumption because they were meal-fed. At the same time, all these lipid parameters were 17% to 20% higher in ad libitum-fed obese than in pair-fed obese group. Histopathological evaluation of the livers in the obese and control groups also showed prominent lipid droplets in the cytoplasm of the obese liver but not in the lean control liver. Thus, the possible causes of obesity in the LA/N-cp obese rats are higher synthetic rates of lipids coupled with lower rate of degradation of cholesterol to bile acids.
Could dancing be coupled oscillation? – the interactive approach to linguistic communication and dynamical systems theory
Authors: Erik Myin, Sonja Smets
Journal: Behavioral and Brain Sciences (2002)

Although we applaud the interactivist approach to language and communication taken in the target article, we notice that Shanker &amp; King (S&amp;K) give little attention to the theoretical frameworks developed by dynamical system theorists. We point out how the dynamical idea of causality, viewed as multidirectional across multiple scales of organization, could further strengthen the position taken in the target article.
THE ANGIOTRIBE IN ABDOMINAL SURGERY.
Authors: HUGH M. TAYLOR
Journal: JAMA (1900)

In the summer of 1899, it was my privilege to see the angiotribe used by Dr. Cleveland, of New York. This demonstration and the interesting paper in which he impressed the advantages of the angiotribe, its<i>modus operandi</i>, its technique, and the very satisfactory results attending its use by himself and others, prompted me, as soon as possible, to obtain an angiotribe and to use it in selected cases. A precaution, impressed by Dr. Cleveland, was borne out by my first experience in ordering an angiotribe. The first instrument I received was found sprung and imperfect, after having been used only once or twice. To stand the great strain upon it, fine workmanship in constructing the angiotribe is essential. We saw Dr. Cleveland break an instrument he was using, and this suggests the advisability of providing oneself with more than one angiotribe. The cost of the angiotribe—$18—is an item in
Primary Myocardial Disease.
Authors: N. O. Fowler
Journal: Annals of Internal Medicine (1961)

s1 May 1961Primary Myocardial Disease.N. O. Fowler, M.D., F.A.C.P., M. Gueron, M.D., D. T. Rowlands Jr., M.D.N. O. Fowler, M.D., F.A.C.P.Search for more papers by this author, M. Gueron, M.D.Search for more papers by this author, D. T. Rowlands Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1033_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis study describes 19 patients with congestive heart failure without clinical or pathologic evidence of a primary cause. Eighteen patients were autopsied; one had left ventricular biopsy at thoracotomy. Their ages were from 18 months to 68 years at death. Seven patients had heart failure for five years or more; three had heart failure for over 10 years. Seven patients were alcoholic and three had nutritional cirrhosis. Transient mitral or tricuspid systolic murmurs and apical protodiastolic gallop rhythm were common. Atrial fibrillation was present in seven patients. The electrocardiograms revealed abnormal left axis deviation in five and left bundle branch... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1033-1033KeywordsAlcoholicsAtrial fibrillationBiopsyCirrhosisElectrocardiographyHeart failureLongitudinal studiesNutritionSystolic ejection murmurThoracotomy ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
SWEAT REDUCING SUBSTANCES IN YEAST DERMATOSES
Authors: THEODORE CORNBLEET
Journal: JAMA (1935)

For a long time it has been suspected that yeast infections of the skin are associated with some error in carbohydrate metabolism. The condition is most prevalent among Jews, a people who are prone to difficulties in sugar metabolism. Moreover, yeasts require a ready supply of sugar to thrive. In addition, yeast infections are fairly common in diabetic patients and in the genital tract of diabetic women. In spite of this evidence, no carbohydrate metabolic error has been definitely linked with the majority of cases of moniliasis. Examination of the blood of most of the affected subjects has not shown it to have any deviations from the normal. Since it would indeed be surprising if any carbohydrate metabolic change should be present without showing itself in the blood, and none has been regularly found there, investigators have been discouraged from looking elsewhere. There are several reasons, however, for suspecting that
High incidence of lichen sclerosus in patients with squamous cell carcinoma of the penis
Authors: J. Powell, A. Robson, D. Cranston, F. Wojnarowska, R. Turner
Journal: British Journal of Dermatology (2001)

There is a well-documented association between lichen sclerosus (LS) and vulval carcinoma in women; however, until recently, there have only been anecdotal reports of penile squamous cell carcinoma (SCC) occurring in men with LS.The incidence of penile carcinoma occurring on a background of LS remains uncertain, and we wished to examine this possible association further.To address this, all the cases (n = 20) of penile SCC held on our pathology database (4 years) were examined. Histology was reviewed, blind to the clinical picture, for evidence of LS, applying strict histological criteria. Subsequently, clinical notes were reviewed for history of LS before the SCC presented, and history of previous circumcision, treatments, node involvement, metastases and death.In eight cases, evidence of LS was found in the excision specimen. Seven of these had well-differentiated SCC. In the 12 cases with no evidence of LS, only three were well differentiated. With case note review, seven had a history of LS (four with histological LS), sometimes preceding the SCC by 10 years. These all had well-differentiated SCC. Ten of the 20 patients are dead, seven from metastatic disease. Four deaths occurred in the 'well-differentiated LS' group, but only one from penile SCC metastatic disease.There appears to be a definite association between SCC of the penis and the presence of LS, similar to that reported between LS and vulval SCC in women. Of the 20 patients with penile SCC studied, 11 had a clinical history and/or histological evidence of LS. However, clinical presentation of the LS or need for circumcision may precede the SCC by many years. As follow-up is impractical, counselling at the time of diagnosis is very important, and it is essential that medical practitioners are aware of this association so that the subsequent risk from SCC is reduced.
Proposal for a consensus terminology in endoscopy: how should different endoscopic imaging techniques be grouped and defined?
Authors: H. Tajiri, H. Niwa
Journal: Endoscopy (2008)

In Japan, gastrointestinal endoscopy began with the introduction of the gastroscope, which prompted active clinical use of endoscopes in subsequent years [1]. After the gastroscope had been introduced into practice, various fiberscopes began to be used clinically. In 1984, electronic video endoscopes were also developed. Unlike fiberscopes in which light signals are directly observed, electronic video endoscopes convert electronic signals into images via semiconductor elements and allow various forms of electronic image processing and analysis.
Abstract 2881: E-FABP protects host from tumor development.
Authors: Yuwen Zhang, Enyu Rao, Bing Li
Journal: Cancer Research (2013)

Abstract Epidermal fatty acid-binding protein (E-FABP) is constitutively expressed in many immune cells, including dendritic cells, macrophages and T lymphocytes. However, the role of E-FABP in host immunity against tumor and cancer development is unknown. We hypothesize that E-FABP plays an essential role in host immune responses to ward off tumor challenges. Here we utilize a murine breast cancer model and E-FABP knockout mice to study the function of E-FABP in host immune responses to tumor challenges. It is found that implanted breast cancer cells develops much faster into tumor in E-FABP knockout mice than in wild type ones. It is also discovered that, when compared to wild type mice, F4/80+CD11c+ macrophages in tumor stroma from E-FABP knockout mice show a defective protective immune response to breast cancer cells. Moreover, tumors in E-FABP knockout mice contained much lower numbers of NK cells, CD8+ and CD4+ T cells than those in WT mice. All these results suggest E-FABP protects host from tumor development, implicating a significant role of E-FABP in host immunity against tumor formation. Citation Format: Yuwen Zhang, Enyu Rao, Bing Li. E-FABP protects host from tumor development. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2881. doi:10.1158/1538-7445.AM2013-2881
Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples
Authors: L-Y Shih, D-C Liang, C-F Huang, Y-T Chang, C-L Lai, T-H Lin, C-P Yang, I-J Hung, H-C Liu, T-H Jaing, L-Y Wang, T-C Yeh
Journal: Leukemia (2007)
George (“Steve”) Hargreaves Dunstone
Authors: Antony Cook, David Wood
Journal: BMJ (2007)

After qualifying, George (“Steve”) Hargreaves Dunstone served as a medical officer with the 1st/7th Gurkha Rifles in Malaya from 1949 to 1951. Subsequent surgical training in the northeast of England included posts in Newcastle upon Tyne and in Darlington, the latter being where he developed …
Modulation of the resorption and osteoconductivity of α-calcium sulfate by histone deacetylase inhibitors
Authors: Hong-Moon Jung, Gin-Ah Song, Yong-Keun Lee, Jeong-Hwa Baek, Hyun-Mo Ryoo, Gwan-Shik Kim, Phil-Hoon Choung, Kyung Mi Woo
Journal: Biomaterials (2009)