tbuckley/cabot-search huggingface dataset:
Sensory testing of recipes masking peanut or hazelnut for double‐blind placebo‐controlled food challenges
Authors: A. Ronteltap, J. Van Schaik, M. Wensing, F. J. Rynja, A. C. Knulst, J. H. M. De Vries
Journal: Allergy (2004)

In a double-blind placebo-controlled food challenge (DBPCFC), it is necessary that recipes comprising the allergen cannot be distinguished from placebo.We investigated whether the method of paired comparisons, a sensory difference test, could be used to test the suitability of recipes for a DBPCFC.We used two recipes, each with three concentrations of peanut or hazelnut flour. The recipe for peanut consisted of mashed potatoes with 2.7, 8.9, or 26.8 mg of peanut flour, and the recipe for hazelnut of oatmeal porridge with 74, 247, or 742 mg of hazelnut flour. Corresponding amounts of protein in the provided 15 g portions of each recipe were 0.7, 2.3, and 6.8 mg for peanut, and 11.6, 39, and 117 mg for hazelnut, respectively. Recipes were offered together with a placebo, and evaluated on sensory features by 81 healthy volunteers.The sensory test was easy to perform. Volunteers were not able to detect peanut flour in mashed potatoes, but they recognized hazelnut flour in oatmeal porridge on visual features.Sensory testing by means of the method of paired comparisons is a useful method to evaluate masking of foods for DBPCFC.
Immune Thrombocytopenia after Losartan Therapy
Authors: Sreenu Ada, Madhuri Yalamanchili, William Friedenberg
Journal: Annals of Internal Medicine (2002)

Letters15 October 2002Immune Thrombocytopenia after Losartan TherapySreenu Ada, MD, Madhuri Yalamanchili, MD, and William Friedenberg, MDSreenu Ada, MDGuthrie/Robert Packer Hospital; Sayre, PA 18840Search for more papers by this author, Madhuri Yalamanchili, MDGuthrie/Robert Packer Hospital; Sayre, PA 18840Search for more papers by this author, and William Friedenberg, MDGuthrie/Robert Packer Hospital; Sayre, PA 18840Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-8-200210150-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:An 82-year-old woman presented with nosebleeds and with easy bruising of 2 weeks' duration. She was not bleeding from any other site and had no history of similar symptoms. Other medical conditions included congestive heart failure and depression. Two weeks before presentation, she stopped taking quinapril and was switched to losartan because of cough. Other medications included nortriptyline and bumetanide, which she had been taking for more than 2 years. The patient had no history suggestive of infection; no history of chemotherapy, radiation, or malignancy; and no family history of any bleeding diatheses.On physical examination, the ... Author, Article, and Disclosure InformationAffiliations: Guthrie/Robert Packer Hospital; Sayre, PA 18840 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOlmesartan worsening known thrombocytopenia. A rare side effect of antihypertensive drugsAngiotensin II type 1 receptor blocker-induced immune thrombocytopenia: a case reportLosartan 15 October 2002Volume 137, Issue 8Page: 704KeywordsHemorrhageIdiopathic thrombocytopenic purpuraLymphocytesLymphoproliferative disorderMedical conditionsMonocytesNeutrophilsPlateletsResearch laboratoriesSplenomegaly ePublished: 15 October 2002 Issue Published: 15 October 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice
Authors: C. Bart Rountree, Shantha Senadheera, Jose M. Mato, Gay M. Crooks, Shelly C. Lu
Journal: Hepatology (2007)

Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the biosynthesis of S-adenosylmethionine. Hepatic MAT activity falls in chronic liver diseases, and mice lacking Mat1a are predisposed to liver injury and develop hepatocellular carcinoma (HCC) spontaneously by 18 months. The current work examined the hypothesis that liver cancer stem cells contribute to HCC in this model. Livers from 6- and 18-month-old Mat1a-knockout (KO) mice and their wild-type (WT) littermates were fractionated and isolated by flow cytometry. CD45- nonparenchymal (NP) cells were cultured using liver stem cell conditions. Cells were analyzed by real-time PCR and fluorescent immunohistochemistry (FIHC). Tumor formation was assessed by injecting 1 x 10(6) CD133+CD49f+ cells intraperitoneally into immune-deficient mice. The proportion of CD49f+ and CD133+ cells in the CD45-NP fraction increased 4.5- to 5.5-fold from 6 to 18 months in KO mice but not in their WT littermates. Compared to CD49f- cells from old KO mice, CD49f+ cells from the same animals had a markedly increased expression of several oncogenes. CD133+ cells with CD49f coexpression were selected in vitro and exhibited rapid growth, with the expression of biliary cytokeratins, alpha-fetoprotein, and c-Met by FIHC. Clonal expansion of single CD133+CD49f+ cells revealed maintenance of bipotency. After CD133+CD49f+ cells were injected into immune-deficient mice, 3 of the 8 mice developed tumors of liver epithelial cells after 6-8 weeks.Mat1a(-/-) mice have expansion of liver stem cells as they age. These cells have increased expression of several oncogenes and are tumorigenic in vivo. This is the first demonstration of adult liver stem cells possessing tumorigenic potential without the use of a carcinogen or manipulation of tumor-suppressor or oncogene expression.
Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner
Authors: Lijian Shao, Wei Feng, Hongliang Li, David Gardner, Yi Luo, Yong Wang, Lingbo Liu, Aimin Meng, Norman E. Sharpless, Daohong Zhou
Journal: Blood (2014)
On Medical Priority
Authors: R. Klein
Journal: New England Journal of Medicine (1969)

The article on Refsum's disease by Herndon, Steinberg and Uhlendorf in this issue of the Journal documents another step forward in knowledge about this rare and interesting disorder. The scientific merit of the demonstration of a disorder in phytanic acid oxidation is unquestioned. Yet in a nation confused about its priorities, we may well ask, "Are our efforts properly expended on such arcane ills rather than upon the many common ills of mankind?" What is the importance of this work for man, and what is its interest for the physician reader? Should it be published in this particular journal? Carried . . .
Data on IVF clinics show wide variation in success rate
Authors: R. Dobson
Journal: BMJ (2002)

Wide variations in the success rates of in vitro fertilisation clinics are shown in data released this Friday by the Human Fertilisation and Embryology Authority.

Some clinics are achieving a success rate as high as 46%, while the rate at others is as low as 10%.

The data also show that overall women starting in vitro fertilisation treatment are more likely to have a child than previously.

Figures supplied to the authority from clinics show that in 2000 and 2001 just over a fifth (21.8%) of in vitro fertilisation treatment cycles …
Bill introduced to thwart kidney brokerage
Authors: Phil Gunby
Journal: JAMA (1983)

Plans by Dr. Harvey Barry Jacobs to set up a brokerage mechanism to match persons wishing to sell and buy kidneys for transplantation have resulted in a bill before the U.S. House of Representatives that would prohibit sales of human organs. The bill, introduced by Congressman Albert Gore, Jr. (D-Tenn.), also calls for a National Center for Organ Transplantation to coordinate existing organ procurement agencies into a network. Jacobs, who has begun contacting hospital administrators about the costs of doing nephrectomies and transplantations, may move his brokerage abroad if the legislation passes.
The Guadalajara Dilemma
Authors: Robert H. Moser
Journal: JAMA (1975)

So much has been written about the "FMG [foreign medical graduate] Situation" that I hesitate to enter these formidable lists. Even the phrase "FMG" evokes emotion and suggests dichotomy. I dislike the phrase, but substitution of a euphemism will not make the problem go away. Clinicians of my generation have all worked with physicians educated abroad. I recall my days of residency and fellowship, enjoying felicitous association with young physicians from Greece, the Netherlands, the Philippines, Italy, the British Isles, Taiwan, France, and Mexico. Later, in the army we trained military medical officers from virtually every country friendly to the United States. I cannot recall any sense of concern about<i>where a</i>physician had trained; our chief interest was the man. Perhaps physicians educated abroad were more varied in background and clinical experience than a comparable group of US-educated physicians. But after a time, differences became less perceptible; I can
Hyperkalaemia in patients in hospital.
Authors: B Paice, J M Gray, D McBride, T Donnelly, D H Lawson
Journal: BMJ (1983)

Significant hyperkalaemia occurred in 406 out of 29 063 patients admitted to a major Scottish teaching hospital in one year (1.4%). Mortality was higher in these patients than in control patients and was strongly correlated with the severity of the hyperkalaemia. Overall seven deaths were directly due to hyperkalaemia (out of 58 deaths among patients with hyperkalaemia). Factors contributing to a poor prognosis were severity and speed of onset of hyperkalaemia and the presence of appreciable renal impairment. Patients with hyperkalaemia were older and more likely to be male; this trend was present in all diagnostic subcategories. Genitourinary disease, gastrointestinal disease, and cancer were significantly more common among the patients with hyperkalaemia than the controls. Hyperkalaemia due to drug treatment was invariably mild and non-fatal, whereas genitourinary disease was often associated with moderate to severe hyperkalaemia, which in two cases proved fatal. Use of electrocardiographic monitoring was rare, and although the treatment of hyperkalaemia was effective, it was often used when not required. Hyperkalaemia is a potential hazard in diabetic ketoacidosis, and use of potassium supplements should be carefully monitored during correction of the acidosis.
Collagenous colitis and coeliac disease.
Authors: E G Breen, C Farren, C E Connolly, C F McCarthy
Journal: Gut (1987)

one swallow to another in the same individual.Although there is a similar variation in manometric- ally recorded swallow wave profiles, it is our practice to record at least 10 swallows in each third of the oesophagus.Thus a 'freak' swallow is unlikely to affect the interpretation of manometry.To us, RT gives no additional information to what can be gleaned from a careful review of a recorded barium swallow, a test which would be done in any case in most patients presenting to us with dysphagia.Indeed, Lorber and Shay4 were using liquid barium transit measurement as long ago as 1955 in the assessment of dysphagia.To date, the published and presented work on RT has failed to convince us that it is a test which can justifiably claim its place along- side barium studies, endoscopy, oesophageal manometry, and 24 hour pH measurement, as clinic- ally useful tests of oesophageal function.
Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma
Authors: J Iqbal, T C Greiner, K Patel, B J Dave, L Smith, J Ji, G Wright, W G Sanger, D L Pickering, S Jain, D E Horsman, Y Shen, K Fu, D D Weisenburger, C P Hans, E Campo, R D Gascoyne, A Rosenwald, E S Jaffe, J Delabie, L Rimsza, G Ott, H K Müller-Hermelink, J M Connors, J M Vose, T McKeithan, L M Staudt, W C Chan
Journal: Leukemia (2007)
Practice Parameter: Simple Maneuver Is Best Therapy for Common Form of Vertigo
Authors: Mike Mitka
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The impact of major surgery on blood coagulation factors and thrombin generation
Authors: McDonald K. Horne, Paula K. Merryman, Ann M. Cullinane, Khanh Nghiem, H. Richard Alexander
Journal: American Journal of Hematology (2007)

Abstract We studied the blood coagulation system of 14 patients with metastatic malignancies before and after they had undergone major surgery. In addition to measuring a battery of coagulation factors, we assessed the function of the system with assays of whole blood thrombin generation. With the exceptions of factor VIII (fVIII), which increased, and fibrinogen and fIX, which did not change, the activities of all the pro‐ and anticoagulant proteins were significantly lower postoperatively. However, the thrombin generating capacity of the system was relatively preserved. Although the integral of thrombin activity over time was lower after surgery, the mean peak thrombin concentration was unchanged and the time to clot formation was shortened. Similar changes could be reproduced by lowering the concentrations of pro‐ and anticoagulant factors together in control blood samples. Therefore, simultaneous reductions in pro‐ and anticoagulant proteins postoperatively worked to maintain the functional integrity of the blood coagulation system. Am. J. Hematol., 2007. Published 2007 Wiley‐Liss, Inc.
Atrioventricular Conduction System in Left Bundle-Branch Block with Normal QRS Axis
Authors: DAVID S. CANNOM, BRUCE N. GOLDREYER, ANTHONY N. DAMATO
Journal: Circulation (1972)

In nine patients with left bundle-branch block (LBBB), normal QRS axis, and normal P-R interval, atrial, His bundle, and ventricular electrograms were recorded. The extrastimulus method was utilized to determine the relative refractoriness of the various components of the atrioventricular conducting system. The functional refractory period (FRP) of the A-V node was normal in all but one patient. In six patients, the effective refractory period (ERP) of the ventricular specialized conducting system (VSCS) was greater than the FRP of the A-V node. The differential refractoriness within the three components of the VSCS was determined. Before the ERP of the VSCS was reached, a leftward shift in the mean QRS axis was noted in all six patients, thus documenting participation of the left anterior division of the LBB in ventricular depolarization. We found no evidence that the left posterior division participated in ventricular activation and conclude that it is functionally silent in LBBB. Conduction abnormalities in the right bundle branch were demonstrated both by long H-V intervals and the fact that its ERP was prolonged. The increased refractoriness of all three divisions of the VSCS suggests that the conduction abnormalities producing evidence of LBBB on the surface are trifascicular in nature.
Acknowledge good intentions of researchers in CFS/ME
Authors: A. M. Santhouse
Journal: BMJ (2011)

There is an obvious paradox in wanting more research into chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) but rejecting research that is not liked, with claims that it is unscientific.1 “Science” is the application of the scientific method, and the sound rebuttals by the …
High-Output Cardiac Failure in Patients with Multiple Myeloma
Authors: W McBride, J D Jackman, R S Gammon, J T Willerson
Journal: New England Journal of Medicine (1988)

CARDIAC involvement in multiple myeloma has been associated with certain complications of severe or prolonged disease.1 Myocardial infiltration with amyloid has been well described as a cause of dilated or restrictive cardiomyopathy and congestive heart failure.2 , 3 The hyperviscosity syndrome induced by marked elevations of the circulating concentration of immunoglobulin in plasma-cell dyscrasias has likewise been associated with congestive heart failure.4 In addition, myocardial ischemia may occur as a result of one or more of these mechanisms combined with marked anemia in patients with multiple myeloma and underlying coronary artery disease. We describe three patients with well-defined multiple myeloma who were . . .
Major Problems in Childhood Cancer
Authors: W. I. Neikirk
Journal: JAMA (1974)

In their preface the editors state that the material in this book was selected on the basis of its clinical relevance and value to the practitioner. The chapters are clinically oriented and are not intended to be comprehensive reviews of the topics discussed. They have fulfilled this purpose admirably. The contributors, well selected, have carried out the stated purposes. They do not overlap in their coverage of material, and have adhered strictly to the clinical approach. The chapters are well titled, with appropriate headings. The format of each chapter is the same, starting with a brief but concise definition of the topic, with statistical information followed by the pathophysiology, clinical features, diagnostic approach, laboratory evaluation and treatment, and ending with the prognosis. Each topic is extremely well-referenced and has an up to date and comprehensive list at the end of each chapter. There are separate indices for authors and subject.
Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C
Authors: Salvatore Petta, Calogero Cammà, Concetta Scazzone, Claudio Tripodo, Vito Di Marco, Antonino Bono, Daniela Cabibi, Giusalba Licata, Rossana Porcasi, Giulio Marchesini, Antonio Craxí
Journal: Hepatology (2009)

25-Hydroxyvitamin D (25[OH]D) can potentially interfere with inflammatory response and fibrogenesis. Its role in disease progression in chronic hepatitis C (CHC) and its relation with histological and sustained virological response (SVR) to therapy are unknown. One hundred ninety-seven patients with biopsy-proven genotype 1 (G1) CHC and 49 healthy subjects matched by age and sex were consecutively evaluated. One hundred sixty-seven patients underwent antiviral therapy with pegylated interferon plus ribavirin. The 25(OH)D serum levels were measured by high-pressure liquid chromatography. Tissue expression of cytochrome (CY) P27A1 and CYP2R1, liver 25-hydroxylating enzymes, were assessed by immunochemistry in 34 patients with CHC, and in eight controls. The 25(OH)D serum levels were significantly lower in CHC than in controls (25.07 ± 9.92 μg/L versus 43.06 ± 10.19; P < 0.001). Lower levels of 25(OH)D were independently linked to female sex (P = 0.007) and necroinflammation (P = 0.04) by linear regression analysis. CYP27A1, but not CYP2R1, was directly related to 25(OH)D levels (P = 0.01), and inversely to necroinflammation (P = 0.01). Low 25(OH)D (odds ratio [OR], 0.942; 95% confidence interval [CI], 0.893–0.994) and cholesterol (OR, 0.981; 95%CI, 0.969–0.992) levels, older age (OR, 1.043; 95%CI, 1.002–1.085), high ferritin (OR, 1.003; 95%CI, 1.001–1.005), and necroinflammation (OR, 2.235; 95%CI, 1.014–4.929) were independently associated with severe fibrosis (F3–F4) by multivariate logistic analysis. Seventy patients (41%) achieved SVR. By multivariate analysis, hepatic steatosis (OR, 0.971; 95%CI, 0.944–0.999), lower cholesterol (OR, 1.009; 95% CI, 1.000–1.018), and 25(OH)D levels (OR, 1.039; 95%CI, 1.002–1.077) were independently associated with no SVR. Conclusion: G1 CHC patients had low 25(OH)D serum levels, possibly because of reduced CYP27A1 expression. Low vitamin D is linked to severe fibrosis and low SVR on interferon (IFN)-based therapy. (HEPATOLOGY 2010.)
Insulin-like Growth Factor-I Receptor Signaling Pathway Induces Resistance to the Apoptotic Activities of SCH66336 (Lonafarnib) through Akt/Mammalian Target of Rapamycin–Mediated Increases in Survivin Expression
Authors: Seung Hyun Oh, Quanri Jin, Edward S. Kim, Fadlo R. Khuri, Ho-Young Lee
Journal: Clinical Cancer Research (2008)

Abstract Although preclinical studies have suggested that farnesyltransferase inhibitors (FTI) have promising antitumor activity, clinical trials have shown that FTI activity in patients is actually limited. The mechanism that induces resistance to FTI treatment is still not fully understood. The FTI SCH66336 has been shown to induce apoptotic and antiangiogenic activities in a subset of head and neck squamous cell carcinoma (HNSCC) and non–small cell lung cancer (NSCLC) cell lines. We therefore investigated the mechanisms mediating resistance to the therapeutic activities of SCH66336 in HNSCC and NSCLC. Our various analyses showed that insulin-like growth factor-I receptor (IGF-IR) activation interferes with the antitumor activity of SCH66336 in HNSCC and NSCLC cells. Treatment with SCH66336 activated the IGF-IR/phosphatidylinositol 3-kinase/Akt pathway, leading to increased mammalian target of rapamycin (mTOR)-mediated protein synthesis of survivin in a subset of HNSCC and NSCLC cell lines that were insensitive to the apoptotic activities of the drug. Inhibition of IGF-IR, Akt, or mTOR or the knockdown of survivin expression abolished resistance to SCH66336 and induced apoptosis in the cells. Overexpression of survivin by the use of adenoviral vector protected SCH66336-sensitive HNSCC cells from the apoptotic activities of the drug. Our results suggest that expression of phosphorylated IGF-IR, phosphorylated Akt, phosphorylated mTOR, and survivin serves as biological markers of SCH66336 responsiveness in HNSCC and NSCLC cells and that SCH66336 induces survivin expression through an IGF-IR/Akt/mTOR–dependent pathway. Thus, combining inhibitors of IGF-IR, phosphatidylinositol 3-kinase/Akt, mTOR, or survivin with SCH66336 may be an effective anticancer therapeutic strategy for patients with HNSCC or NSCLC.
Severe Pulmonic Stenosis with Intact Ventricular Septum and Right Aortic Arch
Authors: WALTER J. GAMBLE, ALEXANDER S. NADAS
Journal: Circulation (1965)

Three cases with pulmonary stenosis, intact ventricular septum, and right aortic arch are presented, along with physiologic data. Two cases had infundibular stenosis and, in addition, an aberrant left subclavian artery. The third case was thought to have valvular stenosis. All three patients have been successfully operated upon and show good clinical results.