Acebutolol-Induced Pleuropulmonary Lupus Syndrome
Authors: N. BURGESS RECORD
Journal: Annals of Internal Medicine (1981)

Brief Reports1 September 1981Acebutolol-Induced Pleuropulmonary Lupus SyndromeN. BURGESS RECORD Jr., M.D.N. BURGESS RECORD Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-3-326 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDrug-induced antinuclear antibodies and systemic lupus erythematosus may result from various cardiovascular drugs (1). Practolol, an early beta-adrenergic blocker, produced a lupus-like syndrome (2).Among current beta-blockers, acebutolol seems most likely to induce antinuclear antibodies. Eight of nine acebutolol-treated patients developed antinuclear antibodies within 24 weeks (3). Three of these showed positive lupus cell preparations, but none developed clinical autoimmune disease. In a larger series, antinuclear antibodies were detected in 28.3% of 46 hypertensive patients treated with acebutolol, compared with 7.7% of 854 patients on other drugs (excluding methyldopa) (4). No clinical evidence of lupus-like syndrome was found. Among several...References1. WILSON J. Antinuclear antibodies and cardiovascular drugs. Drugs. 1980;19:292-305. CrossrefMedlineGoogle Scholar2. LEVYDAVID MD. Immune reactions associated with practolol therapy. Int J Clin Pharm. 1978;16:479-81. Google Scholar3. CODYCALABRESECLOUGHTARAZIBRAVO RLJRE. Development of antinuclear antibodies during acebutolol therapy. Clin Pharmacol Ther. 1979;25:800-5. CrossrefMedlineGoogle Scholar4. BOOTHBULLOCKWILSON RJJ. Antinuclear antibodies in patients on acebutolol. Br J Clin Pharm. 1978;9:515-7. CrossrefGoogle Scholar5. BENSAIDALDIGIERGUALDE JJN. Systemic lupus erythematosus syndrome induced by pindolol. Br Med J. 1979;1:1603-4. CrossrefMedlineGoogle Scholar6. GRIFFITHSRICHARDSON IJ. Lupus-type illness associated with labetalol. Br Med J. 1979;2:496-497. Letter. CrossrefMedlineGoogle Scholar7. HARRISONSISCAWOOD TTW. Propranolol-induced lupus syndrome? Postgrad Med. 1976;59(Jan):241-4. CrossrefMedlineGoogle Scholar8. LEECHASE SP. Drug-induced systemic lupus erythematosus: a critical review. Semin Arthritis Rheum. 1975;5:83-103. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPleurotoxic Drugs—an Update: Someone Else to Blame?Medikamentöse Therapie von Herz- und LungenerkrankungenDrug-Induced DiseaseDrug ReactionsAcebutolol-Induced Subacute Cutaneous Lupus ErythematosusDRUG AND ENVIRONMENTAL LUPUS: CLINICAL MANIFESTATIONS AND DIFFERENCESChapter 3 Health consequences of immunotoxic effectsA Case of Drug-Induced Pneumonitis Caused by CarvedilolBioactivationINTERACTIONS OF AUTONOMIC NERVOUS, NEUROENDOCRINE, AND IMMUNE SYSTEMS IN RHEUMATOID ARTHRITISDRUG-INDUCED AUTOIMMUNE DISORDERSDrug-related lupus syndromes and their relationship to spontaneously occurring systemic lupus erythematosusβ-BlockersBeta blockers may induce in C57BL/6 mice a polyclonal activation of lymphocytes which is not mediated by beta adrenergic receptorsLupus induit par un bêtabloquant : l'acébutololFièvre prolongée lors d'un traitement par acébutololAdverse Reactions and Interactions with β-Adrenoceptor Blocking DrugsAcebutolol: A Review of its Pharmacology, Pharmacokinetics, Clinical Uses, and Adverse EffectsSpecificity of Acebutolol-Induced Antinuclear AntibodiesQuinidine induced lupus syndrome 1 September 1981Volume 95, Issue 3Page: 326-327KeywordsAntinuclear antibodiesAutoimmune diseasesDrugsElectronic medical recordsLupus erythematosus Issue Published: 1 September 1981 PDF DownloadLoading ...