tbuckley/cabot-search huggingface dataset:
Paraproteins of familial MGUS/multiple myeloma target family-typical antigens: hyperphosphorylation of autoantigens is a consistent finding in familial and sporadic MGUS/MM
Authors: Sandra Grass, Klaus-Dieter Preuss, Stephan Thome, Dennis D. Weisenburger, Vinetta Witt, Jane Lynch, Florian Zettl, Lorenz Trümper, Natalie Fadle, Evi Regitz, Henry Lynch, Michael Pfreundschuh
Journal: Blood (2011)
The Patient Risk Tree
Authors: ROBERT W. LYONS
Journal: Annals of Internal Medicine (1982)

Ad Libitum1 April 1982The Patient Risk TreeROBERT W. LYONS, M.D.ROBERT W. LYONS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-4-523_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Patient Risk Tree is a computer program written by the Center for Disease Control for assigning probabilities of nosocomial infection to patients.Amos has diabetes.Carol has Cushing's disease.Frank is in his eighties,With an emphysematous wheeze.For each of them there is a leafAnd there is even a bud for me.Everyone of us has a placeSomewhere on the patient risk tree.As our bodies grow old and witheredThis tree will flourish and bloom.Some plants like the sunlight;This one likes the gloom.And in that last Autumnal windThat must come to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hartford, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1982Volume 96, Issue 4Page: 523-523KeywordsNosocomial infectionsSoftware tools ePublished: 1 December 2008 Issue Published: 1 April 1982 PDF downloadLoading ...
Thrombocytopenia and Sarcoidosis—Reply
Authors: Joseph R. Fontana
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice
Authors: Alberto Pinzon-Charry, Virginia McPhun, Vivian Kienzle, Chakrit Hirunpetcharat, Christian Engwerda, James McCarthy, Michael F. Good
Journal: Journal of Clinical Investigation (2010)

Development of a vaccine that targets blood-stage malaria parasites is imperative if we are to sustainably reduce the morbidity and mortality caused by this infection. Such a vaccine should elicit long-lasting immune responses against conserved determinants in the parasite population. Most blood-stage vaccines, however, induce protective antibodies against surface antigens, which tend to be polymorphic. Cell-mediated responses, on the other hand, offer the theoretical advantage of targeting internal antigens that are more likely to be conserved. Nonetheless, few of the current blood-stage vaccine candidates are able to harness vigorous T cell immunity. Here, we present what we believe to be a novel blood-stage whole-organism vaccine that, by combining low doses of killed parasite with CpG-oligodeoxynucleotide (CpG-ODN) adjuvant, was able to elicit strong and cross-reactive T cell responses in mice. Our data demonstrate that immunization of mice with 1,000 killed parasites in CpG-ODN engendered durable and cross-strain protection by inducing a vigorous response that was dependent on CD4+ T cells, IFN-gamma, and nitric oxide. If applicable to humans, this approach should facilitate the generation of robust, cross-reactive T cell responses against malaria as well as antigen availability for vaccine manufacture.
Body set up to increase numbers taking part in trials
Authors: Rebecca Coombes
Journal: BMJ (2004)

Body set up to increase numbers taking part in trials 365, 149 A new body was launched last week to get the NHS and industry working more closely together to increase the number of patients taking part in clinical trials.The UK Clinical Research Collaboration will bring together key players to speed up the development of medicines in five areas-Alzheimer's disease, stroke, diabetes, mental health, and children's medicine.Representatives from the NHS, industry, the Medical Research Council and other funding bodies, medical charities, and the National Institute for Clinical Excellence (NICE) will make up the new body.Using the successful National Cancer Research Networks organisation as a model, the collaboration will use an initial £24m ($44m; €36m) to set up similar research networks in the five new areas.
TCT-220 The impact of the supply area on the fractional flow reserve value in stable coronary artery disease
Authors: Yasutsugu Shiono, Takashi Kubo, Hiroshi Aoki, Teruaki Wada, Masahiro Takahata, Yuichi Ozaki, Makoto Orii, Kunihiro Shimamura, Kohei Ishibashi, Yamano Takashi, Takashi Tanimoto, Yasushi Ino, Tomoyoshi Yamaguchi, Kumiko Hirata, Toshio Imanishi, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2012)
Estrogenic Activity of Bisphenol A and 2,2-bis( <i>p</i> -Hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles
Authors: Sylvia C. Hewitt, Kenneth S. Korach
Journal: Environmental Health Perspectives (2010)

BackgroundInterest and concern regarding potentially estrogenic substances have resulted in development of model systems to evaluate mechanisms of such chemicals. Microarray studies have indicated that estradiol (E2)-stimulated uterine responses can be divided into early and late phases. Comparison of E2 uterine transcript profiles and those of other estrogenic chemicals of interest in vivo indicates mechanisms and activities of test compounds.ObjectivesWe compared transcript responses and mechanisms of response using mouse reproductive tracts after treatment with E2, estriol (E3), bisphenol A (BPA), and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE).MethodsUterine RNA from ovariectomized wild-type mice, estrogen receptor α (ERα) knockout (αERKO) mice, and mice expressing a DNA-binding–deficient ERα (KIKO) treated with E2, E3, BPA, or HPTE for 2 or 24 hr was analyzed by microarray. Resulting regulated transcripts were compared by hierarchical clustering and correlation analysis, and response patterns were verified by reverse-transcription real-time polymerase chain reaction (RT-PCR).ResultsBoth xenoestrogens, BPA and HPTE, showed profiles highly correlated to that of E2 in the early response phase (2 hr), but the correlation diminished in the later response phase (24 hr), similar to the known weak estrogen E3. Both xenoestrogens also mimicked E2 in samples from KIKO mice, indicating that they are able to utilize the indirect tethering mode of ERα signaling. No response was detected in ERα-null uteri, indicating that ERα mediates the responses.ConclusionOur study forms a basis on which patterns of response and molecular mechanisms of potentially estrogenic chemicals can be assessed.
Clinical vignette: Knee pain
Authors: M. Corbett
Journal: Annals of the Rheumatic Diseases (1985)

800 Farr, Symmons, Bacon patients was detected early and fell again after withdrawal of the drug.but hepatotoxicity may progress to acute focal hepatocellular necrosis' or chronic granulomatous hepatitis. 16The nausea, vomiting, flatulence, and abdominal pain experi- enced by patient 1 are well recognised early side effects of SASP due to the sulphonamide compo- nent and may not be directly associated with the rise in liver enzymes.The mechanism of SASP associated reactions in these two patients is probably due to a hypersensi- tivity reaction resulting from the sulphapyridine moiety of SASP.'2 6 and it may progress to cholestatic jaundice and hepatic injury.Thus early hepatotoxicity should be added to the list of possible complications of SASP thlerapy in RA.It is impor- tant to monitor liver function to detect and reverse this adverse reaction promptly.We airc grateful to Dr Lindia Blcc1cv and Miss R Laswrcncc foi-their help.
Nations with endemic malaria are urged to scrap taxes and tariffs on drugs and tests
Authors: J. Zarocostas
Journal: BMJ (2011)

Antimalaria advocacy groups have renewed calls for an end to taxes and tariffs on vital products used to fight the disease, including drugs, insecticide treated bed nets, and rapid diagnostic tests.

Awa Marie Coll-Seck, executive director of the Roll Back Malaria Partnership, welcomed all initiatives to make these products affordable and accessible. Eliminating the tariffs—which in some countries add 40% to 50% to the price of antimalarial products, would help slash costs and make them affordable and accessible to poor people, experts say.

Data collected by the Malaria Taxes and Tariffs Advocacy Project (M-TAP), a two …
Adynamic Ileus Following Induced Hypotension
Authors: Jen Wen Chen
Journal: JAMA (1985)

<h3>To the Editor.—</h3> During a study of the effects of nitroprusside-induced hypotension on surgical bleeding, we incidentally noticed the frequent occurrence of postoperative adynamic ileus in patients whose mean arterial systolic blood pressure (BP) was maintained at the 50- to 65-mm Hg range intraoperatively. <h3>Study.—</h3> Fifty consecutive patients scheduled for elective total hip replacement were divided into three groups according to their medical condition. Group 1 consisted of 26 healthy patients (American Standards Association physical status, 1 or 2) with no clinical evidence of cerebrovascular disease and with a resting diastolic BP of less than 100 mm Hg. Group 2 included 12 patients with known hypertension and a resting diastolic pressure of greater than 100 mm Hg but with no clinical evidence of cerebrovascular and/or renal disease (ASA physical status 2 or 3). Group 3 included 12 patients, all of whom were ASA physical status 3 or higher, who had
Plasma histamine and bronchial reactivity in allergic asthma
Authors: J. L. Corhay, Th. Bury, R. Louis, M. F. Radermecker
Journal: Allergy (1993)

Histamine is an important mediator of allergic inflammation and bronchial hyperresponsiveness (BHR), a hallmark of asthma. Studies on the relationship between plasma histamine and BHR in allergic asthmatic patients have yielded controversial results. We therefore measured plasma histamine and bronchial reactivity in 30 nonsmoker volunteers taking no medication. Eleven were normal subjects; 19 were stable, mildly allergic asthmatic patients. Venous blood was taken to measure blood cells and basal plasma histamine by radioimmunoassay. After blood sampling, all subjects underwent a measurement of PC20M (concentration of methacholine causing a 20% fall in FEV1). Mean plasma histamine levels were 0.21 +/- 0.1 ng/ml and 0.44 +/- 0.3 ng/ml in normal and asthmatic subjects, respectively (P < 0.05). We found a significant increase of blood eosinophils and basophils in asthmatic patients, and a positive correlation between plasma histamine and circulating basophils. PC20M was greater than 16 mg in normal volunteers, and mean PC20M was 2.1 +/- 2 mg/ml in asthmatic patients. PC20M did not correlate with plasma histamine levels, but it did so negatively with blood eosinophils. The increased plasma histamine concentration in mildly atopic asthmatic patients might be a consequence of the high basophil releasability of atopics and the higher basophil counts in allergic asthma. Plasma histamine is thus unlikely to be a determinant of BHR in asthma.
Academy rash. A probable epidemic of erythema infectiosum ('fifth disease')
Authors: C. Brass
Journal: JAMA (1982)

Over a few weeks, 69 children (13%) enrolled in a private school manifested an erythematous and migratory rash, most commonly on the extremities, along with fever or other systemic or respiratory symptoms. Fever lasted for a mean of four days, and rash, 11 days. Cases appeared in every grade from kindergarten through ninth, and the incidence peaked in the fifth through seventh grades. More boarding students were affected than day students. Secondary cases in households of affected children and among adults from the school were noted. Eighty-eight attempts at virus isolation were unsuccessful. The illnesses were consistent with erythema infectiosum, a disease of unknown etiology, which has occurred in epidemic form in schools and also in sporadic cases. (<i>JAMA</i>1982;248:568-572)
Effects of oral arsenic trioxide therapy on QT intervals in patients with acute promyelocytic leukemia: implications for long-term cardiac safety
Authors: Chung-Wah Siu, Wing-Yan Au, Cindy Yung, Cyrus R. Kumana, Chu-Pak Lau, Yok-Lam Kwong, Hung-Fat Tse
Journal: Blood (2006)
The Irritable Gut: Functional Disorders of the Alimentary Canal
Authors: Charles B. Clayman
Journal: JAMA (1979)

Following an introductory description of the neural, muscular, and hormonal role in intestinal motility, the author discusses the importance of healthy bowel habits and the role of dietary fiber in normal defecation. He then briefly tries to relate the response of the gut to emotions and the importance of sigmoidoscopy in the evaluation of the bowel. The chapters are short, and the explanations are brief—perhaps a bit too brief for the student or generalist interested in basic principles that will permit him to build his understanding of this important segment of gastroenterology from them. For the gastroenterologist the material is rather oversimplified. Discussion of practical clinical aspects of constipation, functional diarrhea, gas, and dyspepsia is replete with numerous pointers that will render diagnosis and management of their problems much easier. In his discussion of laxatives, the author, recognizing and acknowledging the inadequacy and inaccuracy of the classification, nevertheless uses it
"NOSTRUMS AND QUACKERY"
Authors: W. C. Rodgers
Journal: JAMA (1927)

<h3>To the Editor:</h3> —Will you permit an ignorant layman to make a suggestion? I want to suggest that every reputable physician in the United States have and keep constantly on the table in his waiting room Nostrums and Quackery. It will, no doubt, occur to you that one impatiently waiting for his turn will pick up and read a book, paper or magazine while thus marking time that he would not notice under different conditions. It seems to me that a book of this kind and subject would be really refreshing to a patient waiting his turn and that he would be in a peculiarly fitting state of mind to give attention to the practical, common-sense information about the medical frauds that lie in wait for the unsuspecting and ignorant. I believe that if the physicians of the country would adopt this plan,... patients would be pleasantly—not insistently—introduced to the
REACTIONS OF TTIE SMALL VESSELS IN THE EXTRA-EMBRYONIC MEMBRANES AND THE LIMB BUD OF THE DEVELOPING CHICK TO VASOACTIVE AGENTS
Authors: K. J. MOYNAHAN, N. SETHI, P. JOWETT
Journal: British Journal of Dermatology (1970)

Journal Article REACTIONS OF TTIE SMALL VESSELS IN THE EXTRA‐EMBRYONIC MEMBRANES AND THE LIMB BUD OF THE DEVELOPING CHICK TO VASOACTIVE AGENTS Get access K. J. MOYNAHAN, K. J. MOYNAHAN Department of Dermatology, Guy's Hospital Medical School, London Search for other works by this author on: Oxford Academic Google Scholar N. SETHI, N. SETHI Department of Dermatology, Guy's Hospital Medical School, London Search for other works by this author on: Oxford Academic Google Scholar P. JOWETT P. JOWETT Department of Dermatology, Guy's Hospital Medical School, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue s5, 1 May 1970, Pages 77–85, https://doi.org/10.1111/j.1365-2133.1970.tb07992.x Published: 01 May 1970
Cetaceans would be an interesting comparison group
Authors: Lori Marino
Journal: Behavioral and Brain Sciences (2001)

One of the mammalian groups absent from the Finlay et al. study is cetaceans (dolphins, whales, and porpoises). Inclusion of cetaceans would be useful for assessing the generalizability of the authors' conclusions. Recent findings suggest dolphins may differ from the general pattern observed by Finlay et al. I encourage Finlay and her colleagues to include developmental neurobiological data on cetaceans, when available.
Occupational Exposure to Blood among Medical Students
Authors: Patricia M. Tereskerz, Richard D. Pearson, Janine Jagger
Journal: New England Journal of Medicine (1996)

One of the most serious threats medical students face during their clinical training is the possibility of exposure to blood-borne pathogens, with the attendant risk of infection with the human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV). Yet the problem of exposure to contaminated blood among the estimated 50,000 medical students in the United States,1 about half of whom are receiving clinical training in the nation's 126 medical schools at a given time, has received little attention.213 The risk of percutaneous injury to health care workers has been well documented.1416 It is estimated . . .
The sociopath: Cheater or warrior hawk?
Authors: Kent G. Bailey
Journal: Behavioral and Brain Sciences (1995)

Abstract Mealey's excellent target article rests on several assumptions that may be questioned, including the overarching assumption that sociopathy reflects the failure of a small minority of males to cooperate with the larger group. I suggest that violent competition in ancestral bands – and not “cheating” in the “game” of cooperation – was the primary evolutionary precursor of sociopathy. Today's violent sociopath is far more a “warrior hawk” than a failed cooperator.
Efficient Gene Delivery and Selective Transduction of Glial Cells in the Mammalian Brain by AAV Serotypes Isolated From Nonhuman Primates
Authors: Patricia A Lawlor, Ross J Bland, Alexandre Mouravlev, Deborah Young, Matthew J During
Journal: Molecular Therapy (2009)

Adeno-associated viral (AAV) vectors have become the primary delivery agent for somatic gene transfer into the central nervous system (CNS). To date, AAV-mediated gene delivery to the CNS is based on serotypes 1-9, with efficient gene transfer to neurons only-selective and widespread transduction of glial cells have not been observed. Recently, additional endogenous AAVs have been isolated from nonhuman primate tissues. In this study, transduction obtained with AAV serotypes bb2, cy5, rh20, rh39, and rh43 was compared to that obtained with AAV8, another nonhuman primate isolate previously shown to perform well in mammalian brain. Titer-matched vectors encoding the enhanced green fluorescent protein (EGFP) reporter, driven by the constitutive CAG promoter, were injected into the hippocampus, striatum, or substantia nigra (SN) of adult rats. More widespread neuronal transduction was observed following infusion of cy5, rh20, and rh39 than observed with AAV8. Of interest, preferential transduction of astrocytes was observed with rh43. To optimize glial transduction, vector stocks driven by cell-specific promoters were generated-widespread and targeted transduction of astrocytes and oligodendrocytes was observed using rh43 and AAV8, driven by the glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP) promoters, expanding the utility of AAV for modeling and treating diseases involving glial cell pathology.
Reproducibility of tricuspid regurgitant jet velocity measurements in children and young adults with sickle cell disease undergoing screening for pulmonary hypertension
Authors: Robert I. Liem, Luciana T. Young, Amy S. Lay, Stephanie A. Pelligra, Richard J. Labotka, Alexis A. Thompson
Journal: American Journal of Hematology (2010)

Abstract The reproducibility of tricuspid regurgitant jet velocity (TRJV) measurements by Doppler echocardiography has not been subjected to systematic evaluation among individuals with sickle cell disease (SCD) undergoing screening for pulmonary hypertension. We examined sources of disagreement associated with peak TRJV in children and young adults with SCD. Peak TRJV was independently measured and interpreted a week apart by separate sonographers and readers, respectively, in 30 subjects (mean age, 15.8 ± 3.3 years) who provided 120 observations. We assessed intra‐/inter‐reader, intra‐/inter‐sonographer, sonographer‐reader, and within subject agreement using Intraclass Correlation Coefficient (ICC) and Cohen's kappa (κ). Agreement was examined graphically using Bland‐Altman plots. Although sonographers could estimate and measure peak TRJV in all subjects, readers designated tricuspid regurgitation nonquantifiable in 10–17% of their final interpretations. Intra‐reader agreement was highest (ICC = 0.93 [95% CI 0.86, 0.97], P = 0.0001) and within subject agreement lowest (ICC = 0.36 [95% CI 0.02, 0.64], P = 0.021) for single TRJV measurements. Similarly, intra‐reader agreement was highest (κ = 0.74 [95% CI 0.53, 0.95], P = 0.0001) and within subject lowest (κ = 0.14 [95% CI −0.17, 0.46], P = 0.38) when sonographers and readers categorized TRJV measurements. On Bland‐Altman plots, absolute differences in observations increased with higher mean TRJV readings for intra‐/inter‐reader agreement. Peak TRJV measurements in individual children and young adults with SCD are affected by several sources of disagreement, underscoring the need for methodological improvements that ensure reproducibility of this screening modality for making clinical decisions in this population. Am. J. Hematol., 2010. © 2010 Wiley‐Liss, Inc.
291Myocardial dysfunction in hypertrophic cardiomyopathy: primary effects of sarcomeric mutations versus secondary cardiomyocyte remodeling?
Authors: R Coppini, F Gentile, L Mazzoni, C Ferrantini, B Tosi, C Ferrara, J Tardiff, C Tesi, E Cerbai, C Poggesi
Journal: Cardiovascular Research (2014)

Introduction: In HCM human tissue, primary functional alterations at the level of the sarcomeres are associated with secondary changes of Ca2+ handling and membrane EP, leading to a pro-arrhythmogenic phenotype and alteration of myocardial relaxation (Circulation. 2013 Feb 5;127(5):575-84). The relative contribution of primary vs secondary alterations is still unknown.
Effect of Platelet Activating Factor on the Human Nasal Mucosa
Authors: Ulf Pipkorn, Göran Karlsson, Björn Bake
Journal: Allergy (1984)

In order to determine the effect of PAF‐acether on the vascular bed in the human nose, 11 healthy volunteers were studied. Rhinomanometry was performed to determine the effect on the capacitance vessels, and the 133 Xe wash‐out method enabled determination of the mucosal blood flow, regulated mainly by the resistance vessels. These measurements were made before and after topical administration of PAF‐acether in three different doses; 0.26 μg 2.6 μg and 26 μg per nostril. The results indicate that PAF‐acether induces a dose‐dependent vasoconstriction of the capacitance vessels and a reduction in mucosal blood flow. That PAF‐acether should be a principal mediator in the allergic reaction in the human nose is not supported by these findings.