tbuckley/cabot-search huggingface dataset:
Tumor Models (In Vivo/In Vitro)
Authors: T. A. Doucette, L.-Y. Kong, Y. Yang, J. Wei, J. Wang, G. N. Fuller, A. B. Heimberger, G. Rao, N. Ajewung, D. Kamnasaran, A. M. Katz, N. Amankulor, M. Squatrito, D. Hambardzumyan, E. C. Holland, J. Poschl, A. Lorenz, A. Von Bueren, S. Li, A. Peraud, J.-C. Tonn, J. Herms, M. Xiang, S. Rutkowski, H. Kretzschmar, U. Schuller, A. Studebaker, C. Raffel, Y. Aoki, R. Hashizume, T. Ozawa, N. Gupta, C. D. James, A. C. Navis, B. C. Hamans, A. Claes, A. Heerschap, P. Wesseling, J. W. Jeuken, W. P. Leenders, P. A. Agudelo, S. Williams, M. O. Nowicki, J. Johnson, P. K. Li, E. A. Chiocca, J. J. Lannutti, S. E. Lawler, M. S. Viapiano, J. Bergeron, A. Aliaga, B. Bedell, C. Soderquist, A. Sonabend, L. Lei, C. Crisman, J. P. Yun, J. Sisti, M. Castelli, J. N. Bruce, P. Canoll, M. Kirsch, A. Stelling, R. Salzer, C. Krafft, G. Schackert, G. Steiner, R. K. Balvers, S. K. van den Hengel, H. Wakimoto, R. C. Hoeben, S. Leenstra, C. M. Dirven, M. L. Lamfers, N. S. Sabha, S. Agnihotri, A. Wolf, A. von Deimling, S. Croul, A. Guha, U. S. Trojahn, A. Lenferink, B. Bedell, M. O'Connor-McCourt, H. Wakimoto, R. Kanai, W. T. Curry, S. Yip, Z. R. Barnard, G. Mohapatra, A. O. Stemmer-Rachamimov, R. L. Martuza, S. D. Rabkin, Z. A. Binder, V. Salmasi, M. Lim, J. Weingart, H. Brem, A. Olivi, G. J. Riggins, G. L. Gallia, Y. Rong, Z. Zhang, C. Gang, C. Tucker-Burden, E. Van Meir, D. J. Brat, R. K. Balvers, J. J. Kloezeman, A. Kleijn, P. J. French, C. M. Dirven, S. Leenstra, M. L. Lamfers, R. K. Balvers, J. J. Kloezeman, J. K. Spoor, C. M. Dirven, M. L. Lamfers, S. Leenstra, E. Bazzoli, E. I. Fomchenko, N. Schultz, C. Brennan, L. M. DeAngelis, E. C. Holland, S. D. Nimer, M. Squatrito, A. Mohyeldin, W. Hsu, S. R. Shah, H. Adams, P. Shah, L. Katuri, T. Kosztowski, D. M. Loeb, J.-P. Wolinsky, Z. L. Gokaskan, A. Quinones-Hinojosa, I. K. Daphu, H. Immervoll, R. Bjerkvig, F. Thorsen, V. Caretti, S. Idema, I. Zondervan, D. H. Meijer, T. Lagerweij, M. Barazas, W. Vos, B. Hamans, P. van der Stoop, E. Hulleman, P. van der Valk, M. Bugiani, P. Wesseling, W. P. Vandertop, D. Noske, G. J. Kaspers, C. Molthoff, T. Wurdinger, L. M. Chow, R. Endersby, X. Zhu, S. Rankin, C. Qu, J. Zhang, D. W. Ellison, S. J. Baker, V. Tabar, F. LaFaille, L. Studer
Journal: Neuro-Oncology (2010)
Lithium for Zidovudine-Induced Neutropenia in AIDS-Reply
Authors: Victor Herbert
Journal: JAMA (1989)

<h3>In Reply.—</h3> Drs Nathwani and Green are correct that the toxic effects of lithium are a real danger because of the polyinfections and frequent diarrhea of patients with acquired immunodeficiency syndrome (AIDS). We start with 300 mg of lithium carbonate twice daily, and only occasionally have to raise it to three times daily. We monitor serum lithium levels twice weekly for the first few weeks and reduce the dose if any serum lithium level reaches 1.40 mmol/L or if the patient reports a hand tremor or any other sign<sup>1</sup>of a toxic reaction to lithium. We strive for a serum level of 0.60 to 1.20 mmol/L (&gt;1.50 mmol/L signals a toxic effect).<sup>1</sup> Our experience is that lithium does not exacerbate erythrocyte macrocytosis in AIDS. In that connection, we find negative balance for vitamin B<sub>12</sub>and folate to be frequent in AIDS,<sup>2</sup>often being indicators of generalized
Assessment of psychological care in general practice.
Authors: D. Crossley, M. P. Myres, G. Wilkinson
Journal: BMJ (1992)

To pilot a method of assessing psychological care by general practitioners.Prospective examination of psychological care given in general practice by using general health questionnaire with predetermined quantifiable and case specific indices of outcome established at the original consultation.Rural general practice in Clwyd, North Wales.447 consecutive adult general practice attenders.Three month follow up consultation rates, one year retrospective consultation rates, continuity of care, changes in general health questionnaire scores at follow up, general satisfaction, and acceptability of outcome measures.The principal and trainee identified 72 patients with psychological problems, 46 of whom had new conditions. 133 patients scored over 6 on the 28 item general health questionnaire, 33 of whom were identified as new cases by the general practitioners. 62 patients were seen at follow up, including 23 patients identified by the questionnaire but not by the doctor. The doctors used diagnostic terms to describe the presenting condition in 38 cases. At three month follow up the general health questionnaire scores had fallen by more than 5 points in 22/39 patients identified and managed by doctors and 11/23 identified by the questionnaire. The agreed index of good outcome was almost or completely achieved by 20 of the 39 patients managed by doctors.Quantifiable methods of evaluating the quality of the structure, process, and outcome of psychological care can be achieved in general practice.
Avulsion of the upper limb.
Authors: J. A. Barclay
Journal: BMJ (1969)

The clinical features of the steroid " pseudo- rheumatism " were similar to those previously described.`-3Generalized aching, stiffness, and loss of strength and energy occurred in all.Aching in the upper arms and across the shoulders prevented sleep in three patients.Stiff- ness was especially noticeable in the morning on rising, and during the day following periods of
Esophagitis from Candida or Exophiala?
Authors: Mitchell S. Cappell
Journal: Annals of Internal Medicine (1991)

Letters1 July 1991Esophagitis from Candida or Exophiala?Mitchell S. Cappell, MD, PhD, Berj P. Armenian, MDMitchell S. Cappell, MD, PhDSearch for more papers by this author, Berj P. Armenian, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-1-69_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:We describe a patient with human immunodeficiency virus (HIV) infection who experienced odynophagia and who, at endoscopy, had a thin cheesy exudate caused by infection withExophiala jeanselmei, an opportunistic pathogen recently reported to cause other deep-seated infections in immunocompromised patients (1). Our report shows that this fungal infection may mimic the clinical presentation and endoscopic appearance of esophageal candidiasis. Recognizing infection withE. jeanselmeimay be important because the clinical response to therapy for this infection is not well characterized and may be different from that for candidiasis. Fungal cultures are required to differentiate between the...References1. Allred B. Subcutaneous phaeohyphomycosis due to Exophiala jeanselmei in an immunosuppressed patient: case report. N Z Med J. 1990;103:321-322. MedlineGoogle Scholar2. IwatsuMiyaji TM. Phaeomycotic cyst: a case with a lesion containing a wooden splinter. Arch Dermatol. 1984;120:1209-1211. CrossrefMedlineGoogle Scholar3. KerrPerfectCraven CJP. Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis. Ann Intern Med. 1983;99:334-7. LinkGoogle Scholar4. RoncoroniSmayevsky AJ. Arthritis and endocarditis from Exophiala jeanselmei infection [Letter]. Ann Intern Med. 1988;108:773. LinkGoogle Scholar5. HohlHolleyPrevostAjelloPadhye PPELA. Infections due to Wangiella dermatitidis in humans: report of the first documented case in the United States and a review of the literature. Rev Infect Dis. 1983;5:854-64. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School (Rutgers) New Brunswick, NJ 08903-0019 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNosocomial Fungemia Due to Exophiala jeanselmei var. jeanselmei and a Rhinocladiella Species: Newly Described Causes of Bloodstream InfectionPhaeohyphomycosis from Exophiala jeanselmei with Concomitant Nocardia asteroides Infection in a Renal Transplant Recipient: Case Report and Review of the Literature 1 July 1991Volume 115, Issue 1Page: 69-69KeywordsCandidaCandidiasisEndoscopyHIVHIV infectionsOpportunistic infectionsOpportunistic pathogens Issue Published: 1 July 1991 PDF DownloadLoading ...
Guidelines of the French Society of Digestive Endoscopy: Recommendations For Setting Up Cleaning And Disinfection Procedures In Gastrointestinal Endoscopy
Authors: R. Systchenko, B. Marchetti, J. N. Canard, L. Palazzo, T. Ponchon, J. F. Rey, D. Sautereau
Journal: Endoscopy (2000)

Since 1998 the Council of the French Society of Digestive Endoscopy has published standards for good practice in endoscopy. At present these recommendations appear to be the best way of arriving at optimal practice. Written by a group of experts and corrected by an even larger expert group, they are regularly updated in written form in order to help with decision making.
Medical history. Doctors of 1776-I.
Authors: J D Spillane
Journal: BMJ (1976)

It was hot and humid in Philadelphia in July 1776.Horseflies tormented the members of the Continental Congress as they met daily in the Statehouse where, all that year, pressure had been mounting in favour of independence.The city was one of some 38 000 people, larger than Bristol or Dublin, the second largest city in the English-speaking world.Only London was larger.'The population of the 13 colonies was about 3 000 000, and of the 3500 physicians no more than 400 of them held a degree of MB or MD and only 50 had graduated from the two American schools in Philadelphia and New York.2Earlier in the year the publication of Tom Paine's pamphlet Common Sense had exercised a stirring effect, encouraging the doubters, rallying the moderates, and explaining that liberty was not derived from the British constitution but was a right of all mankind.In Philadelphia, where it was printed, "It has fretted some folks here more than a little."3Rumours that German troops were among those arriving to invade the colonies of King George III stunned many and helped to cast the die.Then, on 1 July, news reached Congress that General Howe's invasion force had been sighted off New York: "a stupendous flotilla ... bigger than the Armada."tThe delegates had to decide how to meet this threat.There were the New England colonies (Maine, New Hampshire, Vermont, Connecticut, and Massachusetts); the middle colonies (New York, New Jersey, Maryland, and Rhode Island); and the southern colonies (Virginia, the Carolinas, and Georgia).
Endoscopic Evaluation of the Hypertrophic Pyloric Stenosis in Adult
Authors: M. Saito, H. Kuramitsu, H. Orihata, A. Hirayama, T. Takemoto
Journal: Endoscopy (1974)

Endoscopic evaluation of the hypertrophic pyloric stenosis in the adult was discussed on 10 of 19 cases in Japan including our 4 cases. Nine diffuse forms (by Skoryna) showed “protruded lesion, deformity, irregularity and stenosis of the pyloric ring, pyloric narrowing unaffected by anticholinergic agents, and irregular mucosal folds adjacent to the pylorus”. One focal form showed only a tumor like lesion on the lesser curvature of the pylorus. Associated gastric ulcers should be carefully observed. Frontal view type upper GI endoscope should be used for the diagnosis of the hypertrophic pyloric stenosis in the adult.
Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease
Authors: Kittipong Maneechotesuwan, Xin Yao, Kazuhiro Ito, Elen Jazrawi, Omar S. Usmani, Ian M. Adcock, Peter J. Barnes
Journal: PLoS Medicine (2009)

Peter Barnes and colleagues show that corticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that suppress Th2 cytokine expression. This novel mechanism of corticosteroid action may help explain the efficacy of corticosteroids in allergic diseases.
Abstract 2938: Inhibition of PI3K/AKT and MEK/ERK pathways act independently on p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma
Authors: Sreelatha Gopinath, Kiranmai Alapati, Rama Rao Malla, Christopher S. Gondi, Sanjeeva Mohanam, Dzung H. Dinh, Jasti S. Rao
Journal: Cancer Research (2011)

Abstract Cathepsin B and urokinase plasminogen activator receptor (uPAR) are overexpressed in gliomas. Deregulation of the G1 phase cell cycle machinery is a common feature of cancers. The abundance of cyclin-dependent kinase inhibitor p27Kip1 (p27) during the cell cycle determines whether cells will proliferate or become quiescent. In the present study, we carried out transfections using shRNA against cathepsin B and uPAR. We assessed cell cycle arrest using FACS analysis and used Western blot analysis to detect expression of ERK, AKT, p27, cyclin E, cyclin D, CDK4, CDK2, EGFR, β1 integrins, and the pocket proteins (p-Rb, p107 and p130). Specific inhibitors like Wortmanin (10 µM) and U0126 (10 µM) were used to further determine the roles of the AKT and ERK pathways. We used immunoprecipitation analysis to detect the respective interactions between EGFR and β1, p27 and CDK4, and p27 and CDK2. CHIP analysis was used to check for the recruitment of transcription factors FOXO3a, E2F1 and AP-1 to the p27 promoter. The results of the present study show that shRNA treatment efficiently downregulated expression of cathepsin B and uPAR and induced G0/G1 arrest through upregulation of p27. Downregulation of both p-ERK and p-AKT downstream of EGFR and β1 are involved, but independently, in p27 upregulation. Multiple transcription factors (namely, AP-1, E2F1 and FOXO3a) were involved in upregulation of p27 as determined by luciferase expression under the influence of promoter regions to which these transcription factors bind individually. Also, cathepsin B and uPAR downregulation reduced tumor growth and increased p27 nuclear expression in vivo. In summary, the reduction of p-ERK and AP-1, the increased expression of E2F1 and FOXO3a, and the reduced association of cyclin D-CDK4 and cyclin E-CDK2 complexes contributed to p27 upregulation as well as G0/G1 arrest induced by downregulation of cathepsin B and uPAR. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2938. doi:10.1158/1538-7445.AM2011-2938
Brachial plexus neuropathy after radiotherapy can be treated by specialist surgeons
Authors: L C Bainbridge
Journal: BMJ (1996)

EDITOR,—Neuritis is an unfortunate complication of radiotherapy,1 for which patients may be denied treatment. I have been told by several patients that their oncologist told them that the pain was untreatable. I have also been told by oncologists that the pain is due to tumour infiltration and is a sign …
Enteroviral infections in children with malignant disease: A 5-year study in a single institution
Authors: Maria A. Moschovi, Katerina Katsibardi, Maria Theodoridou, Athanassios G. Michos, Athanassios Tsakris, Nikolaos Spanakis, Fotini Tzortzatou-Stathopoulou
Journal: Journal of Infection (2006)
Lung abscess and reactive arthritis: rare complications of leptospirosis.
Authors: R J Winter, A Richardson, M J Lehner, B I Hoffbrand
Journal: BMJ (1984)

We also studied 10 fit women volunteers aged 21-36 two to four days before and six to eight days after the onset of menstruation.Height, weight, and leg volume were measured at the beginning and end of a working day, and leg symptoms at the end of the day were recorded.Almost every subject had lost height and weight after menstruation, but leg volume increased in some and decreased in others and the changes were not significant.The amount of leg swelling and severity of symptoms at the end of the day were no different before and after menstruation.There were no differences in basal leg volume and leg swelling between those taking oral contraceptives (n= 6) and those not. CommentWe found a significant increase in leg volume during the day in fit young adults, and almost three quarters of this swelling occurred in the morning.The legs that ached were those that swelled most.The increase in leg volume may be due to increased interstitial fluid and venous distension, and accumulation of metabolites or passive stretching of skin, fascia, and veins may cause aching.Body weight increases before menstruation due to salt and water retention induced by oestrogen and progesterone.1 2 An increase in total body water might result in greater leg volume.It is therefore surprising that in our study neither basal leg volume nor leg swelling were greater before menstruation.This finding may be related to the fact that none of our subjects experienced any premenstrual symptoms.
Audit of surgical practice in a community hospital.
Authors: D B Johnson
Journal: BMJ (1984)

The results of a prospective analysis of one year's surgery on inpatients in a busy community hospital showed that a high quality of surgery may be achieved with safety and low rates of complications. The results of a retrospective analysis of certain aspects of surgery was just as encouraging. Surgery that is performed in a community hospital is convenient for the patient, provides continuity of care by the general practitioner, and waiting list times are short. Surgical facilities can form an integral part of the comprehensive service provided by a community hospital and can lighten the caseload for minor surgery at the district general hospital. Close liaison between the two hospitals is essential.
Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2
Authors: Carlos M. Ferrario, Jewell Jessup, Mark C. Chappell, David B. Averill, K. Bridget Brosnihan, E. Ann Tallant, Debra I. Diz, Patricia E. Gallagher
Journal: Circulation (2005)

Background— Angiotensin-converting enzyme 2 (ACE2) has emerged as a novel regulator of cardiac function and arterial pressure by converting angiotensin II (Ang II) into the vasodilator and antitrophic heptapeptide, angiotensin-(1–7) [Ang-(1–7)]. As the only known human homolog of ACE, the demonstration that ACE2 is insensitive to blockade by ACE inhibitors prompted us to define the effect of ACE inhibition on the ACE2 gene. Methods and Results— Blood pressure, cardiac rate, and plasma and cardiac tissue levels of Ang II and Ang-(1–7), together with cardiac ACE2, neprilysin, Ang II type 1 receptor (AT 1 ), and mas receptor mRNAs, were measured in Lewis rats 12 days after continuous administration of vehicle, lisinopril, losartan, or both drugs combined in their drinking water. Equivalent decreases in blood pressure were obtained in rats given lisinopril or losartan alone or in combination. ACE inhibitor therapy caused a 1.8-fold increase in plasma Ang-(1–7), decreased plasma Ang II, and increased cardiac ACE2 mRNA but not cardiac ACE2 activity. Losartan increased plasma levels of both Ang II and Ang-(1–7), as well as cardiac ACE2 mRNA and cardiac ACE2 activity. Combination therapy duplicated the effects found in rats medicated with lisinopril, except that cardiac ACE2 mRNA fell to values found in vehicle-treated rats. Losartan treatment but not lisinopril increased cardiac tissue levels of Ang II and Ang-(1–7), whereas none of the treatments had an effect on cardiac neprilysin mRNA. Conclusions— Selective blockade of either Ang II synthesis or activity induced increases in cardiac ACE2 gene expression and cardiac ACE2 activity, whereas the combination of losartan and lisinopril was associated with elevated cardiac ACE2 activity but not cardiac ACE2 mRNA. Although the predominant effect of ACE inhibition may result from the combined effect of reduced Ang II formation and Ang-(1–7) metabolism, the antihypertensive action of AT 1 antagonists may in part be due to increased Ang II metabolism by ACE2.
Selected pesticide residues or metabolites in blood and urine specimens from a general population survey.
Authors: R S Murphy, F W Kutz, S C Strassman
Journal: Environmental Health Perspectives (1983)

The National Center for Health Statistics collaborated with the National Human Monitoring Program of the U.S. Environmental Protection Agency (EPA) in a four-year study to assess the exposure of the general population to selected pesticides through analysis of blood serum and urine specimens. Specimens were collected on a national probability half sample of persons 12-74 years of age from 64 locations across the United States comprising the sample areas in the Second Health and Nutrition Examination Survey (NHANES II) and analyzed for selected organochlorine, carbamate, chlorophenoxy and organophosphorus pesticides. Medical, nutritional and pesticide usage data are also available for each sample person. Preliminary results of the blood serum and urine analyses indicate that the general population is being exposed to some of these types of pesticides. Since 1970, EPA has conducted a national probability sampling of human adipose tissue. Specimens obtained on a survey design representative of the general population were analyzed for selected organochlorine pesticides and toxic chemicals. Findings from the 1978 survey also indicate exposure of the general population to some of these chemicals. Medical data collected from both surveys have yielded no overt correlations between health effects and residue levels. More intensive statistical analyses are underway to investigate the possible existence of more subtle relationships.
While Coping With This Season's Influenza, Experts Plan for Season Still to Come
Authors: Charles Marwick
Journal: JAMA (1988)

A NEW VARIANT of influenza virus is responsible for most of this winter's outbreaks. Unlike last winter, when most of the influenza was caused by the H1N1 form of the A virus, the current outbreaks are caused by the H3N2 form, which itself is significantly different antigenically from an H3N2 virus in circulation last year. (The two influenza A viruses are distinguished by two major antigenic glycoproteins on their surface—H for hemagglutinin and N for neuraminidase.)  The new variant was isolated in Sichuan, China, last April ( JAMA 1988;259:977). It is the virus responsible for an outbreak among passengers on a ship cruising Chinese and Korean waters last October. Passengers who had been vaccinated with the current influenza vaccine experienced the same attack rate as those who had not been immunized.  This is an unusual situation and we cannot conclude from this experience that the current influenza vaccine is failing to
Comparison of Limb and Precordial Vectorcardiographic Systems
Authors: ERNEST FRANK, GEORGE E. SEIDEN
Journal: Circulation (1956)

Two advanced types of vectorcardiographic systems have been applied to 104 miscellaneous patients for the purpose of comparing practical features and electric results. The 2 systems showed satisfactory average agreement, as expected, but there were marked individual differences in many cases. Despite corrections for torso shape and typical eccentric ventricle location, the limb electrode system yielded results significantly outside attainable limits, and hence is considered unsatisfactory for quantitative work despite its practical advantages.