tbuckley/cabot-search huggingface dataset:
Laparoscopic Repair of Paraesophageal Hernia
Authors: H. Athanasakis, A. Tzortzinis, J. Tsiaoussis, J.-S. Vassilakis, E. Xynos
Journal: Endoscopy (2001)

Surgical repair of paraesophageal hernia is mandatory, due to the risk of severe complications, and it can be accomplished via the laparoscopic route. This study presents the results of laparoscopic repair of paraesophageal hernia combined with anterior hemifundoplication.During a two-year period, ten consecutive patients with paraesophageal hernia (six men, four women; mean age 73, range 55-82) underwent laparoscopic treatment. Five patients presented with symptoms of gastroesophageal reflux, while another four reported lower chest pain. There was one patient in whom the paraesophageal hernia was manifested with upper gastrointestinal bleeding. Six patients had type III hiatal hernia. They all underwent esophagography, upper gastrointestinal endoscopy, stationary manometry, and 24-hour ambulatory pH-metry, preoperatively and within three months postoperatively. At laparoscopy, the hernia content was completely reduced, the sac excised, and the diaphragmatic crura approximated. The operation was completed with an anterior hemifundoplication. In three cases, a prosthetic mesh was applied to close the hiatal defect securely.Operating times ranged from 75 min to 125 min (mean 90 min). There were no postoperative deaths. One patient developed atelectasis, and another had empyema of the left pleura, treated with drainage and antibiotics. All patients but one were discharged on the second or third postoperative day. At the three-month follow-up examination, none of the patients had symptoms related to the paraesophageal hernia, gastroesophageal reflux, or fundoplication. Esophagography demonstrated restoration of normal anatomy at the gastroesophageal region, while esophageal motility was improved, and esophageal pH-metry showed no gastroesophageal reflux.Laparoscopic repair of paraesophageal hernias is a safe, technically feasible, and well tolerated procedure, which offers rapid and total relief of symptoms. The addition of an anterior hemifundoplication not only cures preexisting gastroesophageal reflux, but also prevents the development of postoperative gastroesophageal reflux.
ERYTHEMATOUS GROUP OF SKIN DISEASES WITH ESPECIAL REFERENCE TO ABDOMINAL PAIN
Authors: I. RIDGEWAY TRIMBLE
Journal: JAMA (1931)

Willan,<sup>1</sup>in 1808, was the first to describe a case of purpura associated with violent vomiting, excruciating pains in the bowels, and anasarcous swellings of the legs, thighs and hands. Schönlein,<sup>2</sup>in 1848, emphasized the arthritic and Henoch,<sup>3</sup>in 1868, the visceral manifestations. Osler,<sup>4</sup>in 1895, wrote of the constant association of various erythematous lesions of the skin with purpura and with abdominal pain and was criticized at the time for including such a varied group of cases under one head. It is generally agreed that his observations and his association were entirely correct. Furthermore, it is felt that the skin manifestations, especially erythema, urticaria, angioneurotic edema and purpura, the abdominal crises, the arthritic pains and the type of nephritis are manifestations of a single pathologic process. The present series includes thirteen children from the ages of 10 months to 12 years, observed at the Johns
Personnel Exposures Associated with the Therapeutic Use of Radium, Radon and Cobalt-60
Authors: Egilda DeAmicis, Russell F. Cowing
Journal: New England Journal of Medicine (1954)

BEFORE the protection problems of personnel exposed to radium, radon and cobalt-60 are considered it seems advisable to review some of the terminology that is generally used in conjunction with radioactive materials.The term radioisotope is applied to a material that has exactly the same chemical properties as a non-radioactive substance, the difference being that the radioisotope has different physical properties in that it emits radiation, which may be in the form of either particles or rays or both, depending on the specific isotope involved. The unit of dose for a radioisotope is the millicurie, which is an accepted rate . . .
1107 Induction of intestinal multidrug resistance-associated proteins 2 and 3 (MRP2, MRP3) by cholic acid (CA) and ursodeoxycholic acid (UDCA) in mice
Authors: G ZOLLNER, P FICKERT, M WAGNER, A FUCHSBICHLER, D SILBERT, J GUMHOLD, K ZATLOUKAL, H DENK, M TRAUNER
Journal: Hepatology (2003)
The Incidence of Scabies and its Apparent Dependence upon Subnormal Intelligence
Authors: G. A. Hodgson
Journal: BMJ (1941)

MEDICAL JOURN;AL that the presence of upper abdominal hyperaesthesia in an Army dyspeptic is sufficient to warrant hospital investigation.Summary Abdominal hyperaesthesia has been tested in 30 Army dyspeptics suspected of peptic ulceration.Its presence has coincided considerably with abnormal radiological findings.It is claimed that such a test may give R.A.M.C. officers in charge of troops some clear indication of which dyspeptic cases will require hospital investigation and which may be retained with the unit.
New pathways for medical education
Authors: D. C. Tosteson
Journal: JAMA (1991)

It is timely and encouraging to note the appearance, in this issue ofThe Journal, of an article on reform of medical education.<sup>1</sup>The editors deserve credit for featuring an article on medical education, and the authors merit praise for designing and carrying out a careful assessment of the opinions of teachers and administrators about reform. Dr Cantor and his coauthors conclude that there is "a restlessness among leaders of medical education" consulted in their survey. They note that "except for basic sciences faculty, a majority of educators stated that 'fundamental changes' are needed in medical student education in the United States." What are the origins of these feelings of concern in the minds of those who are responsible for educating the physicians for the future? The authors cite several criticisms that have been made of contemporary medical education. In my opinion, the prevalent anxiety of medical educators is
Racial Differences in Mortality Among Patients With Acute Ischemic Stroke
Authors: Ying Xian, Robert G. Holloway, Katia Noyes, Manish N. Shah, Bruce Friedman
Journal: Annals of Internal Medicine (2011)

Background: Black patients are commonly believed to have higher stroke mortality. However, several recent studies have reported better survival in black patients with stroke. Objective: To examine racial differences in stroke mortality and explore potential reasons for these differences. Design: Observational cohort study. Setting: 164 hospitals in New York. Participants: 5319 black and 18 340 white patients aged 18 years or older who were hospitalized with acute ischemic stroke between January 2005 and December 2006. Measurements: Influence of race on mortality, examined by using propensity score analysis. Secondary outcomes were selected aspects of end-of-life treatment, use of tissue plasminogen activator, hospital spending, and length of stay. Patients were followed for mortality for 1 year after admission. Results: Overall in-hospital mortality was lower for black patients than for white patients (5.0% vs. 7.4%; P < 0.001), as was all-cause mortality at 30 days (6.1% vs. 11.4%; P < 0.001) and 1 year (16.5% vs. 24.4%; P < 0.001). After propensity score adjustment, black race was independently associated with lower in-hospital mortality (odds ratio [OR], 0.77 [95% CI, 0.61 to 0.98]) and all-cause mortality up to 1 year (OR, 0.86 [CI, 0.77 to 0.96]). The adjusted hazard ratio was 0.87 (CI, 0.79 to 0.96). After adjustment for the probability of dying in the hospital, black patients with stroke were more likely to receive life-sustaining interventions (OR, 1.22 [CI, 1.09 to 1.38]) but less likely to be discharged to hospice (OR, 0.25 [CI, 0.14 to 0.46]). Limitations: The study used hospital administrative data that lacked a stroke severity measure. The study design precluded determination of causality. Conclusion: Among patients with acute ischemic stroke, black patients had lower mortality than white patients. This could be the result of differences in receipt of life-sustaining interventions and end-of-life care. Primary Funding Source: American Heart Association Founders Affiliate.
Journal impact factors for 2003: Thorax increases
Authors: J A Wedzicha
Journal: Thorax (2004)

The impact factor for Thorax is rising

Impact factors for journals for the year 2003 have recently been published and we are delighted that the impact factor for Thorax has risen to 4.188. It is now the second highest ranked conventional respiratory journal in terms of impact factor, behind the American Journal of Respiratory and Critical Care Medicine , and has overtaken the American Journal of Respiratory Cell and Molecular Biology . The impact factors for the main …
A prognostic model for short term adverse events in normotensive patients with pulmonary embolism
Authors: Mariette J. Agterof, Roger E.G. Schutgens, Noureddine Moumli, M.J.C. Eijkemans, René van der Griend, Ellen A.M. Tromp, Douwe H. Biesma
Journal: American Journal of Hematology (2011)

Abstract Risk stratification of patients with PE has gained interest in terms of the identification of patients in whom treatment on an outpatient base can be considered. Previous studies are of limited value due to their focus on adverse clinical events within several months after diagnosis of PE. We developed a prognostic model, based on easily accessible, clinical, and laboratory parameters, to predict adverse events during the first 10 days after the diagnosis of acute PE. We have analyzed the data of 210 outpatients with confirmed PE. Collected data included medical history, pulse rate, blood pressure, NT‐proBNP, and D‐dimer concentrations. The primary outcome was the occurrence of adverse clinical events in a 10 day follow‐up period. Our final prognostic model to predict short‐term adverse events consists of NT‐proBNP levels, D‐dimer concentrations, pulse rate, and the occurrence of active malignancy; the total score ranges from 0 to 37 points. Patients with a low score (no active malignancy, pulse rate &lt;90 bpm, NT‐proBNP &lt;500 pg/ml, and D‐dimer &lt;3,000 μg/l FEU) have a 10‐day adverse event risk &lt;1.5%. This risk increases to over 30% in patients with a maximum score, based on high pulse rate, D‐dimer concentrations, and NT‐proBNP levels. Our prognostic model, once prospectively validated in an independent sample of patients, can be used in the early risk stratification of PE to estimate the risk of adverse events and to differentiate between candidates for in‐ or out‐ hospital treatment. Am. J. Hematol. 2011. © 2011 Wiley‐Liss, Inc.
Safe and effective application of anti-TNF- in a patient infected with HIV and concomitant Crohn's disease
Authors: B Beltran, P Nos, G Bastida, M Iborra, M Hoyos, J Ponce
Journal: Gut (2006)

In his recent commentary, Pinzani discussed approaches to non-invasive evaluation of liver fibrosis and addressed some of the methods currently under investigation ( Gut 2006; 55 :310–12). We agree that liver histology is a surrogate end point and Pinzani emphasised the need for longitudinal studies based on hard clinical endpoints. However, he states “At present, CT and MR can indicate the presence of cirrhosis with high specificity but with very low sensitivity”. In reply, we wish to counter this statement and would like to present data from emerging technologies, including magnetic resonance spectroscopy (MRS), ultrashort echo time (UTE) MR imaging (MRI), and microbubble ultrasound.

We used 31P MRS in vivo to characterise hepatic fibrosis in chronic hepatitis C (CHC) infection.1 The phosphomonoester to phosphodiester (PME/PDE) ratio provided an index of cell membrane turnover and was found to correlate closely with disease severity, assessed by liver histology (Ishak system). A PME/PDE ratio ⩾0.3 provided a sensitivity and specificity of 82% and 81%, respectively, for the diagnosis of cirrhosis, comparable with many indirect serological markers. There was a monotonic increase in …
Number of offspring and maternal allergy
Authors: F. Forastiere, J. Sunyer, S. Farchi, G. Corbo, R. Pistelli, S. Baldacci, M. Simoni, N. Agabiti, C. A. Perucci, G. Viegi
Journal: Allergy (2005)

The consistent association seen between family size and childhood allergy has led to the 'hygiene hypothesis', namely that a lower frequency of infections in early childhood is associated with an increased risk of asthma and hay fever. Maternal atopy, however, is a strong predictor of childhood asthma and hay fever. If maternal atopy is inversely related to the number of siblings then the role of siblings in the development of childhood atopy, the basic tenet of the 'hygiene hypothesis', is challenged. We evaluated the association between number of pregnancies and number of live births with lifetime occurrence of maternal wheeze, asthma, allergic rhinitis, and allergic conjunctivitis in a cross-sectional study in four areas in Italy. A total of 1755 (35-74 year old) nonsmoking women filled a questionnaire on reproductive history as well as on lifetime occurrence of symptoms/diseases. The number of live births was inversely related to lifetime allergic rhinitis (P-value for trend=0.031) and allergic conjunctivitis (P-value for trend=0.011). The odds ratios for those with 4+ children (in comparison with those having 0-1) were: 0.53 (95% CI: 0.27-1.04) and 0.42 (95% CI: 0.22-0.81), respectively. A similar trend was seen for number of pregnancies, although not statistically significant. No association was found between number of pregnancies and number of live births with wheeze or asthma. The results may be interpreted as an indication that maternal atopy influences pregnancy outcomes or that pregnancy itself has an effect on maternal atopy.
Dietary Guidelines in the 21st Century—a Time for Food
Authors: Dariush Mozaffarian, David S. Ludwig
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors' reply to Cortese
Authors: L. Batstra, R. Thomas, G. Mitchell
Journal: BMJ (2013)

We recently expressed our concern that changing the age of onset criterion for attention-deficit/hyperactivity disorder (ADHD) from 7 to 12 years in the Diagnostic and Statistical Manual of Mental Disorders , fifth edition (DSM-5) might increase the risk of misdiagnosing pubertal restlessness and distractibility as ADHD.1 Cortese thinks that this is not supported by empirical evidence,2 and he refers to …
Optimizing the Impact of Drugs on Symptom Burden in Older People With Multimorbidity at the End of Life
Authors: Danijela Gnjidic, Sallie-Anne Pearson, Sarah N. Hilmer
Journal: JAMA Internal Medicine (2014)

To the Editor We commend Chaudhry et al1 on their excellent article that reported high prevalence of symptoms that negatively affect functioning and quality of life in a cohort of older community-dwelling people with multimorbidity and a life expectancy of less than 1 year.
Evolutionary Action Score of <i>TP53</i> Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients
Authors: Abdullah A. Osman, David M. Neskey, Panagiotis Katsonis, Ameeta A. Patel, Alexandra M. Ward, Teng-Kuei Hsu, Stephanie C. Hicks, Thomas O. McDonald, Thomas J. Ow, Marcus Ortega Alves, Curtis R. Pickering, Heath D. Skinner, Mei Zhao, Eric M. Sturgis, Merrill S. Kies, Adel El-Naggar, Federica Perrone, Lisa Licitra, Paolo Bossi, Marek Kimmel, Mitchell J. Frederick, Olivier Lichtarge, Jeffrey N. Myers
Journal: Cancer Research (2015)

Abstract TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC), with mutations occurring in over two thirds of cases; however, the predictive response of these mutations to cisplatin-based therapy remains elusive. In the current study, we evaluate the ability of the Evolutionary Action score of TP53-coding variants (EAp53) to predict the impact of TP53 mutations on response to chemotherapy. The EAp53 approach clearly identifies a subset of high-risk TP53 mutations associated with decreased sensitivity to cisplatin both in vitro and in vivo in preclinical models of HNSCC. Furthermore, EAp53 can predict response to treatment and, more importantly, a survival benefit for a subset of head and neck cancer patients treated with platinum-based therapy. Prospective evaluation of this novel scoring system should enable more precise treatment selection for patients with HNSCC. Cancer Res; 75(7); 1205–15. ©2015 AACR.
189 EFFECT OF IRON CHELATION THERAPY WITH DEFERASIROX (EXJADE®, ICL670) OR DEFEROXAMINE ON HEPATOCELLULAR INFLAMMATION AND LIVER FUNCTION IN PATIENTS WITH TRANSFUSIONDEPENDENT ANEMIA
Authors: Y. Deugnier, B. Turlin, M. Ropert-Bouchet, B. Rabault, P. Brissot
Journal: Journal of Hepatology (2008)
Abstract 4190: ADAM23: Biomarker for nonmelanoma skin cancer disease progression
Authors: Lisan S. Peng, Suzanne Regan
Journal: Cancer Research (2011)

Abstract The ADAMs (A Disintegrin and Metalloproteinase) comprise a family of multidomain transmembrane and secreted proteins involved in cytokine and growth factor release, proteolysis and cell adhesion. Multiple family members have been shown to play a role in cancer formation and disease progression. Decreased ADAM23 expression has been demonstrated in human breast, colon, gastric, head and neck, brain and pancreatic cancers and is believed to be associated with a more malignant or metastatic phenotype. Substantially more than 1 million cases of non-melanoma skin cancer (NMSC) occur annually in the United States according to the American Cancer Society. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the two major types of NMSC and most are related to chronic sun exposure. We have demonstrated by microarray analysis that ADAM23 expression is decreased in human keratinocytes chronically irradiated with a solar-simulated light source. Using a human SCC skin carcinogenesis model, we have demonstrated that decreased ADAM23 expression correlates with disease progression. Preliminary immunohistochemical analysis of human SCC samples also demonstrates decreased ADAM23 expression. We believe that ADAM23 may serve as a biomarker of human skin SCC disease progression. This may be important for earlier detection and for the possible development of targeted therapy that may serve as an alternative to potentially disfiguring surgical treatment. This work was supported in part by PHS grant CA27502 and CA23074 from the National Cancer Institute and the National Institutes of Health. It was also supported in part by start-up funds supplied by the Department of Medicine at the University of Arizona School of Medicine. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4190. doi:10.1158/1538-7445.AM2011-4190
Atlas of Rectoscopy and Colonoscopy
Authors: Phillip M. Berman
Journal: JAMA (1980)

<i>Atlas of Rectoscopy and Colonoscopy</i>is a concise, practical monograph. The quality of the written material, which is generously illustrated with schematic drawings, makes this much more than a picture book. Each brief section is adequately referenced with citations of the current American and European literature. The authors deal with every aspect of lower gastrointestinal (GI) tract endoscopy, including the indications for anoscopy, proctoscopy (10 to 12 cm), rectoscopy (30 cm), total colonoscopy, and the new fiberoptic sigmoidoscopy (65 to 105 cm). Other topics include the selection of equipment, patient preparation, technique of examinations, description of normal and abnormal findings, and potential complications and how to avoid them. Anal and proctologic problems are dealt with in relative depth and clarity. The highlight of this book is a series of 124 four-color photographs whose overall technical quality is unequaled in other endoscopic atlases and no doubt responsible for the $53.90 price
Antibodies to retroviral proteins in Sjogren's syndrome.
Authors: R Cattaneo, C Tosoni, M Franzini, N Manca, M Gelmi, A Turano, F Trotta, M Govoni
Journal: Annals of the Rheumatic Diseases (1993)

Antibodies to retrovi proteins in Sjogren's syndrome Sir: Recently, increased frequen( bodies to retroviral proteins has t in serum samples from patients wi Sj6gren's syndrome.Talal et al re presence of antibodies to p24 gag HIV-I in serum samples of 14 of (30%) with primary Sjogren's 4 Moreover, they found that two sa reacted with p17 protein.Coll et reported high prevalence (33%) of to p24 in 21 patients with primar syndrome.2In addition, they fox seven positive samples reactivity HIV-1 proteins namely, with samples), with p55 (six), and with No other studies have hitherto these interesting results.The aim of our study was to v findings in northern Italian pai primary Sj6gren's syndrome.We
[698] ALLELE AND GENOTYPE FREQUENCIES OF POLYMORPHIC CYP2E1, ADH2 AND ALDH2 IN A HUICHOL POPULATION
Authors: B.E. Bastidas-Ramirez, E. Zepeda-Carrillo, E. Gordillo-Bastidas, D. Gordillo-Bastidas, M. Gonzalez-Hita, J.I. Garcia-Banuelos, A. Panduro
Journal: Journal of Hepatology (2007)
Unacceptable face of private practice: prescription of controlled drugs to addicts.
Authors: T Bewley, A H Ghodse
Journal: BMJ (1983)

Self administered questionnaires completed by 69 out of 100 consecutive drug addicts attending two drug dependence clinics suggested that some private general practitioners were easily persuaded to prescribe controlled drugs. These drugs were usually methadone, dipipanone-cyclizine (Diconal), and methylphenidate (Ritalin). Numbers of new narcotic addicts notified to the Home Office confirmed the practice, which may lead to a severe spread of addiction, as occurred in the 1960s with heroin and cocaine. If the General Medical Council or a tribunal set up in accordance with the Misuse of Drugs Act 1971 cannot stop the practice, then the present licensing system should be extended to include all controlled drugs.
Acute Mediastinal Emphysema Complicating Eclampsia
Authors: Robert W. Kistner
Journal: New England Journal of Medicine (1951)

THE occurrence of acute mediastinal emphysema during labor and delivery is an unusual and sometimes puzzling complication. Numerous case reports of this entity have been described during the past fifty years, but simultaneously occurring convulsive eclampsia was noted in only a few instances. The incidence of this complication seems to have decreased (if case reports in the literature may be used as an index) during the last fifteen years, probably as a result of improvements in analgesia, anesthesia and "prophylactic" forceps.Gordon1 in 1927 noted that the midwife Louise Bourgeois, attending the Queen of France in 1617, recognized the condition . . .