tbuckley/cabot-search huggingface dataset:
Vocational training for general practice in inner London. Is there a dearth? And if so what's to be done?
Authors: T. Harris, T. Silver, E. Rink, S. Hilton
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To identify the nature and extent of any vocational training deficit within the London initiative zone and investigate the reasons. <b>Design</b>: Collation of statistics and postal questionnaire surveys. <b>Setting</b>: Thames regions inside and outside the London initiative zone. <b>Subjects</b>: General practice registrars, trainers, principals from non-training practices, and vocational training course organisers. <b>Main outcome measures</b>: Trends in numbers of general practice registrars, proportions of trainers, views on current vocational training in inner London. <b>Results</b>: Numbers of general practice registrars fell significantly between 1988 and 1993 within the London initiative zone and in England overall. The number of registrars within the zone fell by more than in the rest of the Thames regions, where the decline was not statistically significant. A lower proportion of principals were approved as trainers within the zone than in the rest of the Thames regions and England overall. In their responses to the survey (88% of inner London registrars responded and 81% of outer Thames registrars) registrars suggested that improving remuneration and personal safety would make training in London more attractive. Trainers and non-trainers (response rates 89% and 66% respectively) also suggested increasing remuneration for trainers together with more protected time for training. <b>Conclusions</b>: Less vocational training takes place within the London initiative zone than in the rest of the Thames regions and England overall, although there are discrepancies in official statistics. As well as specific recommendations for improving recruitment to vocational training in inner London, measures to tackle inner city deprivation should also remain high on the political agenda. <h3>Key messages</h3> Key messages The proportion of general practice principals who are approved trainers is lower in inner London than in the rest of the Thames regions or England Increased remuneration and improvements to personal safety are required to attract registrars to inner London Only 28% of inner London general practice registrars intend to become principals immediately on completion of their training Increased remuneration and protected time for training are required to encourage more principals to become trainers
Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells.
Authors: J S Marshall, I Leal-Berumen, L Nielsen, M Glibetic, M Jordana
Journal: Journal of Clinical Investigation (1996)

Mast cells have been implicated in a number of diseases involving chronic inflammation including asthma, rheumatoid arthritis, and inflammatory bowel diseases. They are a potent source of several cytokines, including IL-6 and TNF-alpha. Freshly isolated rat peritoneal mast cells will produce IL-6 in response to anti-IgE, LPS, PGE1, or PGE2; however, the mechanisms by which such cytokine production is regulated are poorly understood. IL-10 is recognized as an important immunoregulatory cytokine with effects on T cell development and the production of inflammatory cytokines. IL-10 has previously been described to enhance mast cell development in the context of IL-3 and IL-4. In the current study, we have examined the ability of IL-10 to modulate rat peritoneal mast cell IL-6 and TNF-alpha production in response to a variety of stimuli. We have observed that recombinant murine IL-10 can inhibit the production of both IL-6 and TNF-alpha by mast cells without altering the degree of histamine release in response to anti-IgE. Concentrations of IL-10 as low as 0.2 ng/ml were sufficient to inhibit IL-6 production by LPS- or anti-IgE-activated cells significantly. IL-10 also inhibited PGE1- and PGE2-induced IL-6 production. The relative potency of IL-10 as an inhibitor of mast cell IL-6 production was highly dependent upon the stimulus used, with a 10-fold difference in the IC50 for LPS- or anti-IgE-activated cells (0.21 ng/ml) and cells activated with a combination of LPS and PGE2 (2.29 ng/ml). This suggests that prostanoids may limit the ability of IL-10 to modulate mast cell IL-6 production in the context of inflammation. These data have important implications for the regulation of mast cell IL-6 in inflammatory diseases involving prostanoid production and the effects of treatment with cyclooxygenase inhibitors. Our results also demonstrate a dual role for IL-10 on mast cells as a growth factor and inhibitor of cytokine production.
965-50 Accumulation of Collagen in the Cardiac Interstitium of Dogs with Chronic Heart Failure is Associated with Decreased Capillary Density and Increased Oxygen Diffusion Distance
Authors: Hani N. Sabbah, Victor G. Sharov, Jane M. Cook, Hisashi Shimoyama, Michael Lesch, Sidney Goldstein
Journal: Journal of the American College of Cardiology (1995)
Suspension of GP over treatment of drug misuser is extended for 12 months
Authors: C. Dyer
Journal: BMJ (2013)

A Scottish GP who was suspended for six months last March for failings in his treatment of a drug misuser has been suspended for another 12 months.

Dennis Miller did not appear at the Medical Practitioners Tribunal Service hearing in Manchester, but his solicitors sent a letter inviting the panel to find his fitness to practise still impaired and suggesting further suspension of another six …
Inhibition of endothelial nitric oxide synthase induces and enhances myocardial fibrosis
Authors: Andrey Kazakov, Rabea Hall, Philippe Jagoda, Katrin Bachelier, Patrick Müller-Best, Alexander Semenov, Frank Lammert, Michael Böhm, Ulrich Laufs
Journal: Cardiovascular Research (2013)

AimsThe endothelial nitric oxide synthase (eNOS) contributes to cardiac remodelling. We studied the role of eNOS in the development of myocardial fibrosis during cardiac overload.
Alison Sarah Jane Prosser
Authors: R J. Burden
Journal: BMJ (2003)

A pioneer in radiology and one of the most skilled arteriographers of his time David Sutton was at the helm of the dramatic advances that took place in clinical radiology in the second half of the 20th century.His technical brilliance was combined with an analytical mind and a lucid literary styleboth of which he ascribed to the rigours of a classical education-and kept him at the forefront of radiological writing and publishing up to a few days before he died.He was born David Suchanitsky in Manchester to an impoverished Jewish immigrant family, who had fled persecution in Russia at the turn of the century.While he was a student at Manchester University, having won a scholarship there, the family name was changed to Sutton by deed poll.After qualifying, he served with the Royal Army Medical Corps in Burma for three and a half years, during which time his enthusiasm for radiology was born.After demobilisation he trained in London, at the Hospital for Nervous Diseases, Queen Square, intending to become a neuroradiologist.Dr James Bull had recently introduced the technique of percutaneous carotid angiography there, and David Sutton became the second person in the United Kingdom to practise this technique.While at Queen Square he wrote an MD thesis on the radiology of the aqueduct and fourth ventricle.He then moved to the Middlesex Hospital, where he developed the techniques of peripheral angiography and of placental angiography.In 1953 he became a consultant radiologist at St Mary's Hospital, Paddington, at a time when major strides in vascular surgery
Predictors of the Performance of Foreign Medical Graduates on the 1982 Certifying Examination in Internal Medicine
Authors: John J. Norcini
Journal: JAMA (1986)

This study describes a cohort of foreign medical school graduates (FMGs) who first sat for the American Board of Internal Medicine's (ABIM) 1982 certifying examination, compares their performance with that of US medical school graduates, describes differences between US citizen FMGs and alien FMGs, and examines which background factors predict success on the ABIM examination. Data for this study were derived by combining information retained by the Educational Commission for Foreign Medical Graduates with ABIM data. Most FMGs who took the 1982 ABIM certifying examination for the first time were educated in and citizens of Asia, but a sizable minority were US citizens educated in Europe. Scores and program directors' ratings were lower for FMGs than US medical school graduates, and they attended different types of training programs. United States citizen FMGs were very similar to alien FMGs. Foreign medical school graduates who did well on the ABIM examination had done well on the Educational Commission for Foreign Medical Graduates examination and were rated highly by their residency program director. (<i>JAMA</i>1986;256:3367-3370)
Loss of TCR-beta F1 and/or EZRIN expression is associated with unfavorable prognosis in nodal peripheral T-cell lymphomas
Authors: S M Rodríguez-Pinilla, M E C Sánchez, J Rodríguez, J F García, B Sánchez-Espiridión, L F Lamana, G Sosa, J C Rivero, J Menárguez, I B Gómez, F I Camacho, P R Guillen, C P S Orduña, G Rodríguez, C Barrionuevo, R Franco, M Mollejo, J F Marco, R D de Otazu, M A Piris
Journal: Blood Cancer Journal (2013)

Nodal peripheral T-cell lymphoma (nodal PTCL) has an unfavorable prognosis, and specific pathogenic alterations have not been fully identified. The biological and clinical relevance of the expression of CD30/T-cell receptor (TCR) genes is a topic under active investigation. One-hundred and ninety-three consecutive nodal PTCLs (89 angioimmunoblastic T-cell lymphomas (AITL) and 104 PTCL-unspecified (PTCL-not otherwise specified (NOS)) cases) were analyzed for the immunohistochemical expression of 19 molecules, involving TCR/CD30 pathways and the associations with standard prognostic indices. Mutually exclusive expression was found between CD3 and TCR-beta F1 with CD30 expression. Taking all PTCL cases together, logistic regression identified a biological score (BS) including TCR molecules (TCR-beta F1 and EZRIN) that separates two subgroups of patients with a median survival of 34.57 and 5.20 months (P<0.001). Multivariate analysis identified BS and the prognostic index for PTCL (PIT) score as independent prognostic factors. This BS maintained its significance in multivariate analysis only for the PTCL-NOS subgroup of tumors. In AITL cases, only a high level of ki67 expression was related to prognosis. A BS including molecules involved in the TCR signaling pathway proved to be an independent prognostic factor of poor outcome in a multivariate analysis, specifically in PTCL-NOS patients. Nevertheless, validation in an independent series of homogeneously treated PTCL patients is required to confirm these data.
AAV Genome Loss From Dystrophic Mouse Muscles During AAV-U7 snRNA-mediated Exon-skipping Therapy
Authors: Maëva Le Hir, Aurélie Goyenvalle, Cécile Peccate, Guillaume Précigout, Kay E Davies, Thomas Voit, Luis Garcia, Stéphanie Lorain
Journal: Molecular Therapy (2013)

In the context of future adeno-associated viral (AAV)-based clinical trials for Duchenne myopathy, AAV genome fate in dystrophic muscles is of importance considering the viral capsid immunogenicity that prohibits recurring treatments. We showed that AAV genomes encoding non-therapeutic U7 were lost from mdx dystrophic muscles within 3 weeks after intramuscular injection. In contrast, AAV genomes encoding U7ex23 restoring expression of a slightly shortened dystrophin were maintained endorsing that the arrest of the dystrophic process is crucial for maintaining viral genomes in transduced fibers. Indeed, muscles treated with low doses of AAV-U7ex23, resulting in sub-optimal exon skipping, displayed much lower titers of viral genomes, showing that sub-optimal dystrophin restoration does not prevent AAV genome loss. We also followed therapeutic viral genomes in severe dystrophic dKO mice over time after systemic treatment with scAAV9-U7ex23. Dystrophin restoration decreased significantly between 3 and 12 months in various skeletal muscles, which was correlated with important viral genome loss, except in the heart. Altogether, these data show that the success of future AAV-U7 therapy for Duchenne patients would require optimal doses of AAV-U7 to induce substantial levels of dystrophin to stabilize the treated fibers and maintain the long lasting effect of the treatment.
Hebiatric Psychosomatic Medicine
Authors: Mauricio Knobel
Journal: Psychotherapy and Psychosomatics (1979)

Adolescent disease should not be considered as something similar to infantile pathology or adult sicknesses. Special consideration must be given to the adolescent as such, taking into account the characteristics of adolescents as described in the 'Normal Adolescence Syndrome'. Symptom formation follows the same pattern as described elsewhere for children, adolescents and adults, but with very special differences in this stage of human development. Hysterical, hypochondriacal and psychotic types of psychosomatic illnesses can be described with the qualification of 'adolescent type'. Hebiatric medicine must be the specialized approach to illnesses in this developmental stage and must define its study object: the adolescent. Interviewing, clinical examination, diagnosis treatment and prognosis are of a specialized kind and the psychosomatic approach is also different. There are some more typical hebiatric pathologies that must be considered properly.
Severe Left Ventricular Dyssynchrony Is Associated With Poor Prognosis in Patients With Moderate Systolic Heart Failure Undergoing Coronary Artery Bypass Grafting
Authors: Martin Penicka, Jozef Bartunek, Otto Lang, Karel Medilek, Petr Tousek, Marc Vanderheyden, Bernard De Bruyne, Michaela Maruskova, Petr Widimsky
Journal: Journal of the American College of Cardiology (2007)
The geographic origin of<i>Helicobacter pylori</i>isolated from Costa Rican patients
Authors: Silvia E Molina-Castro, Dayana Herrera, Wendy Malespín-Bendaña, Vanessa Ramírez, Clas Une
Journal: Gut Microbes (2014)

Helicobacter pylori infects a significant proportion of the world population and it is associated with pathologies which include chronic atrophic gastritis, peptic ulcer, and gastric neoplasias such as gastric adenocarcinoma and MALT lymphoma. Costa Rica has a high prevalence of the infection and an elevated incidence of gastric cancer and its associated mortality. The global population structure for H. pylori has been established using a MLST scheme. The population structure of the strains of H. pylori circulating in Costa Rica is currently unknown. We characterized the geographical origin of 24 H. pylori isolates from Costa Rican patients. We identified 142 new alleles for the genes included in the scheme and in eight of the 24 isolates from Costa Rican patients, all seven alleles sequenced were described for the first time. Twenty-one isolates from Costa Rican patients group with hpEurope strains and the remaining three isolates grouped with hspWAfrica isolates (Bayesian posterior probability values above 0.70, P = 0.05, after 2 000 000 generations). The obtained result in the MLST analysis was not unexpected and reflects the genetic composition of the Costa Rican population.
Special care nurseries: admitting to a policy.
Authors: E Hey
Journal: BMJ (1983)

Few criteria exist for identifying which babies merit special nursing care, and many asymptomatic babies are offered such care unnecessarily. Birth weight is usually used to identify babies in need of special care at birth, but gestational age is a better discriminator. Babies of more than 35 weeks9 gestation do not normally require admission to a special care nursery. Those preterm babies who are admitted can usually be discharged at 37 weeks9 gestation even if they still weigh less than 2000 g.
Hypersthenuria and Carbenicillin
Authors: CLEMENT DEZIEL
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 November 1978Hypersthenuria and CarbenicillinCLEMENT DEZIEL, M.D.CLEMENT DEZIEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-723_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the paper by Zwelling and Balow in the August issue, "Hypersthenuria in High-Dose Carbenicillin Therapy" (Ann Intern Med89:225-226, 1978). The authors may be interested to learn that we previously reported this phenomenon (1). Further, we suggested that, as a bedside rule, when a patient with normal kidney function is receiving carbenicillin, his real specific gravity could be calculated by subtracting from the measured specific gravity a factor equal to six times the urine carbenicillin concentration; that concentration is obtained by dividing 80% of the daily carbenicillin load by the 24-h urine volume....Reference1. DEZIEL C, DAIGNEAULT B, MARC-AURELE J, ALBERT G, and BRODEUR A: High urine specific gravity induced by carbenicillin. Lancet 2:980, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CLEMENT DEZIEL, M.D.Affiliations: Hôpital du Sacré-Coeur Montreal, PQ H4J 1C5 Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1978Volume 89, Issue 5_Part_1Page: 723-723KeywordsAttentionKidneysUrine ePublished: 1 December 2008 Issue Published: 1 November 1978 PDF downloadLoading ...
THE RACIAL DISTRIBUTION OF ISOHEMAGGLUTININ GROUPS
Authors: JULIAN H. LEWIS
Journal: JAMA (1922)

According to our present understanding of human isohemagglutinins, there exist in the blood two types of specific agglutinating substances, which may be designated a and b. In the red cells there are two specific types of agglutininogenic substances, which may be called A and B. The agglutinin of Type a will agglutinate only cells containing the agglutininogenic substance A, and Agglutinin b will agglutinate only cells containing Agglutininogen B. Obviously, one type of agglutinin will occur only in the absence of its corresponding agglutininogen, a fact utilized in classifying samples of blood. A given specimen of blood may contain either one of these specific agglutinins, or both, or neither. This distribution of agglutinins and agglutininogens makes it possible to divide all samples of human blood into four different groups. One group contains both types of specific agglutininogens, but the serum contains no agglutinins. A second group contains Agglutinin b and
Abstract 5470: Pre-clinical characterization of ARGX-110: A neutralizing, humanized monoclonal antibody to the human CD70 antigen with enhanced ADCC properties.
Authors: Karen Silence, Hans De Haard, Torston Dreier, Peter Ulrichts, Mahan Moshir, Sofie Gabriels, Alain Thibault
Journal: Cancer Research (2013)

Abstract The expression of CD70 is normally restricted to activated B- and T- cells, as well as mature dendritic cells. Overexpression has been documented in a variety of solid and hematological tumors, where it is thought to play a role in evasion of immune surveillance. ARGX-110 is a defucosylated, humanized IgG1 monoclonal antibody that selectively targets and neutralizes CD70, a ligand of CD27. A detailed biological and functional characterization of ARGX-110 was carried out to support its clinical development for the treatment of cancers dependent on signaling through the CD70/CD27 axis. In competitive equilibrium binding experiments, ARGX-110 bound to human and cynomolgus monkey CD70 with affinities of approximately 0.4 nmol/L and 0.6 nmol/L, respectively. ARGX-110 inhibited in a dose-dependent fashion CD70/CD27-induced IL-8 release in Raji cells with IC50 values of 0.1 nmol/L. CD70 is minimally internalized (&amp;lt;40%) by most hematological cell lines, thus providing a plausible rationale to develop a therapeutic mAb designed to enhance ADCC. In cell depletion studies, ARGX-110 was associated with comparable to better cell lysis compared to Rituximab. Cell lysis by ARGX-110 was not dependent on the internalization rate of the ARGX-110/CD70 complex in hematological cell lines. Independence from CD70 copy numbers at the cell surface was also demonstrated. In a Burkitt lymphoma (CD70+ Raji cells) SCID mouse model, ARGX-110 administered intraperitoneally twice weekly at doses ranging from 0.001 to 10 mg/kg starting one day after inoculation resulted in a dose-response effect on animal survival. In cynomolgus monkeys, ARGX-110 did not demonstrate any toxicity upon repeated administration of high doses of 30 mg/kg. B, T and NK cell numbers remained unaltered. ARGX-110 is currently in phase I clinical trial for patients with CD70+ malignancies. Citation Format: Karen Silence, Hans De Haard, Torston Dreier, Peter Ulrichts, Mahan Moshir, Sofie Gabriels, Alain Thibault. Pre-clinical characterization of ARGX-110: A neutralizing, humanized monoclonal antibody to the human CD70 antigen with enhanced ADCC properties. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5470. doi:10.1158/1538-7445.AM2013-5470 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Vocal Cord Nodules in Children
Authors: Hugh H. Hussey
Journal: JAMA (1975)

You might call them "the screamers"—youngsters 4 or 5 years old in whom vocal cord nodules develop, with consequent raspiness or hoarseness of voice when used loudly and at high pitch. Toohill tells about them in the current issue of the<i>Archives of Otolaryngology</i>(101:591-595, 1975). The author describes 77 children; the number of boys exceeded that of girls by a ratio of 3:1. The peak age of incidence is between the ages of 5 and 10 years, with vocal cord nodules tending to develop in girls slightly earlier than in boys. Of the 77 children, one was an only child; 13 were the oldest in the families, and 63 had one or more older siblings. Toohill believes that the vocal cord nodules in children are invariably bilateral, although he was able to discover nodules on only one vocal cord in one patient. Although a number of the children had
Automated impedance-based energy adjustment for defibrillation: experimental studies.
Authors: R E Kerber, D McPherson, F Charbonnier, R Kieso, P Hite
Journal: Circulation (1985)

In defibrillation, current flow depends on the energy selected and the transthoracic impedance. If transthoracic impedance is high, current flow may be inadequate to defibrillate. We developed a method by which high transthoracic impedance is automatically compensated for by an increase in operator-selected energy when impedance is high. Transthoracic impedance was predicted in advance of the first shock by passing a low-level current between the defibrillator electrodes during the defibrillator charge cycle; a microprocessor monitored current flow and determined impedance. In 28 mongrel dogs we manipulated transthoracic impedance by placing glycerin-soaked gauze pads between the paddle electrodes and the chest. If the predicted impedance exceeded a preset value, the delivered energy was automatically increased by 40% or 100%. Using this impedance-based energy adjustment technique, we found significant improvements in current flow and success rate of shocks when energy was automatically increased to compensate for high transthoracic impedance. The use of transthoracic impedance as a basis for energy adjustment appears a promising technique to minimize the hazards of high electrical energy; it allows low-energy shocks in most patients while avoiding inappropriate low energies in patients with high impedance. Clinical trials are justified.