tbuckley/cabot-search huggingface dataset:
Permanent Pacemaker Insertion After CoreValve Transcatheter Aortic Valve Implantation
Authors: M.Z. Khawaja, R. Rajani, A. Cook, A. Khavandi, A. Moynagh, S. Chowdhary, M.S. Spence, S. Brown, S.Q. Khan, N. Walker, U. Trivedi, N. Hutchinson, A.J. De Belder, N. Moat, D.J. Blackman, R.D. Levy, G. Manoharan, D. Roberts, S.S. Khogali, P. Crean, S.J. Brecker, A. Baumbach, M. Mullen, J.-C. Laborde, D. Hildick-Smith
Journal: Circulation (2011)

Permanent pacemaker (PPM) requirement is a recognized complication of transcatheter aortic valve implantation. We assessed the UK incidence of permanent pacing within 30 days of CoreValve implantation and formulated an anatomic and electrophysiological model.Data from 270 patients at 10 centers in the United Kingdom were examined. Twenty-five patients (8%) had preexisting PPMs; 2 patients had incomplete data. The remaining 243 were 81.3±6.7 years of age; 50.6% were male. QRS duration increased from 105±23 to 135±29 milliseconds (P<0.01). Left bundle-branch block incidence was 13% at baseline and 61% after the procedure (P<0.001). Eighty-one patients (33.3%) required a PPM within 30 days. Rates of pacing according to preexisting ECG abnormalities were as follows: right bundle-branch block, 65.2%; left bundle-branch block, 43.75%; normal QRS, 27.6%. Among patients who required PPM implantation, the median time to insertion was 4.0 days (interquartile range, 2.0 to 7.75 days). Multivariable analysis revealed that periprocedural atrioventricular block (odds ratio, 6.29; 95% confidence interval, 3.55 to 11.15), balloon predilatation (odds ratio, 2.68; 95% confidence interval, 2.00 to 3.47), use of the larger (29 mm) CoreValve prosthesis (odds ratio, 2.50; 95% confidence interval, 1.22 to 5.11), interventricular septum diameter (odds ratio, 1.18; 95% confidence interval, 1.10 to 3.06), and prolonged QRS duration (odds ratio, 3.45; 95% confidence interval, 1.61 to 7.40) were independently associated with the need for PPM.One third of patients undergoing a CoreValve transcatheter aortic valve implantation procedure require a PPM within 30 days. Periprocedural atrioventricular block, balloon predilatation, use of the larger CoreValve prosthesis, increased interventricular septum diameter and prolonged QRS duration were associated with the need for PPM.
294 EVALUATION OF SERUM M30 AND M65 CELL DEATH MARKERS AS BIOMARKERS FOR DISEASE PROGRESSION IN PATIENTS WITH HBV-RELATED ACUTE-ON-CHRONIC LIVER FAILURE
Authors: B. Zhu, Z. Wan, Y. Rong, A. Zhang, H. Zang, S. You, L. Xiao, S. Xin
Journal: Journal of Hepatology (2013)
When Did Artificial Heart Implants Begin?-Reply
Authors: Virginia S. Cowart
Journal: JAMA (1988)

<h3>In Reply.</h3> —Early attempts to devise an artificial heart focused on the device as a bridge to transplantation and not as a permanent replacement. In 1969, Denton Cooley, MD, implanted an artificial heart in a 47-year-old patient who survived for 65 hours.<sup>1</sup>There were critics who said that the heart had been inadequately tested in animals and that the quality of life that the device could provide did not merit trial in a human.<sup>2</sup>In 1981, Cooley attempted a second implant. That patient was maintained for 54 hours before receiving a heart transplant; he died eight days later. In both instances, the question was whether the device was capable of sustaining life so that it could actually be considered an artificial heart. However, interest in developing a total artificial heart seems to date from about 1963<sup>3</sup>and, in that sense, Dr Hall is correct in saying that
Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma
Authors: Paul M. Barr, Thomas P. Miller, Jonathan W. Friedberg, Derick R. Peterson, Andrea M. Baran, Megan Herr, Catherine M. Spier, Haiyan Cui, Denise J. Roe, Daniel O. Persky, Carla Casulo, Jamie Littleton, Mark Schwartz, Soham Puvvada, Terry H. Landowski, Lisa M. Rimsza, Robert T. Dorr, Richard I. Fisher, Steven H. Bernstein, Margaret M. Briehl
Journal: Blood (2014)
Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction.
Authors: N Ashizawa, K Graf, Y S Do, T Nunohiro, C M Giachelli, W P Meehan, T L Tuan, W A Hsueh
Journal: Journal of Clinical Investigation (1996)

Angiotensin II (AII) is a critical factor in cardiac remodeling which involves hypertrophy, fibroblast proliferation, and extracellular matrix production. However, little is known about the mechanism by which AII accelerates these responses. Osteopontin is an acidic phosphoprotein with RGD (arginine-glycine-aspartate) sequences that are involved in the vascular smooth muscle cell remodeling process. We identified the presence of osteopontin mRNA and protein in cultured rat cardiac fibroblasts and its prominent regulation by AII (10(-11) M). Osteopontin message levels were increased fourfold (P < 0.01) and protein fivefold (P < 0.05) at 24 h after addition of AII (10(-7) M). This response was inhibited by the AT1 receptor blocker, losartan. Osteopontin mRNA levels were increased in hypertrophied ventricles from animals with renovascular hypertension (1.6-fold, P < 0.05) and aortic banding (2.9-fold, P < 0.05). To examine the function of osteopontin, we determined its effects on (a) the ability of cardiac fibroblasts to contract three-dimensional collagen gels and (b) cardiac fibroblast growth. A monoclonal antibody against osteopontin partially blocked AII-induced three-dimensional collagen gel contraction by cardiac fibroblasts (64+/-4 vs. 86+/-5% in the presence of antibody, P < 0.05), while osteopontin itself promoted contraction of the gels by fibroblasts (71+/-5%, P < 0.05 compared with control). Either a monoclonal antibody against beta3 integrin which is a ligand for osteopontin or the RGD peptide blocked both AII and osteopontin-induced collagen gel contraction. Thus, the osteopontin RGD sequence binds to beta3 integrins on the fibroblast to promote fibroblast binding to collagen. All induced a threefold increase in DNA synthesis of cardiac fibroblasts, which was completely blocked by antibodies against osteopontin and beta3 integrin, or by RGD peptide, but not by controls. Thus, All-induced growth of cardiac fibroblasts also requires osteopontin engagement of the beta3 integrin. Taken together, these results provide the first evidence that osteopontin is a potentially important mediator of AII regulation of cardiac fibroblast behavior in the cardiac remodeling process.
Remarks ON SOME POINTS IN THE TREATMENT OF NERVE INJURIES
Authors: J. Sherren
Journal: BMJ (1910)

THE importance of the early diagnosis and correct treat.ment of injury of one of the nerve trunks of a limb is difficult to over-estimate.Injury, for example, of the median, ulnar, or musculo-spiral nerves, unless com.pletely recovered from, leaves the patient permanently unfitted to follow any employment involving the full, skilled use of that limb.I have pointed out I that after primary suture of any one of these nerves recovery may be perfect, the part being restored to a condition indistinguishable from normal; that2 the same may occur after incomplete division; but, on the other hand, after secondary suture the prospect of complete recovery is not so good, and sensory recovery is rarely perfect.Considerable responsibility attaches to BEFEB:ENCES.
Pulmonary vascular dilatation and diffusion-dependent impairment of gas exchange in liver cirrhosis
Authors: AB Crawford, J Regnis, L Laks, P Donnelly, LA Engel, IH Young
Journal: European Respiratory Journal (1995)

To test the hypothesis that diffusion-limitation for oxygen is due to abnormal vascular dilatation and significantly contributes to the arterial hypoxaemia of liver cirrhosis requires an experimental approach that detects both diffusion-limitation for oxygen and the presence of abnormal dilatation of pulmonary vessels exposed to alveolar gas. We therefore studied the gas exchange of a 64 year old man with alcoholic liver cirrhosis and severe resting arterial hypoxaemia (arterial oxygen tension (Pa,O2) 7.5 kPa) whilst breathing air and 100% O2 using conventional blood gas (CBG) analysis, the multiple inert gas elimination technique (MIGET) and whole body scintigraphy (WBS) following the i.v. administration of radiolabelled boli of macroaggregates with a minimum diameter of 15 microM. During air breathing, there was a consistently positive difference between the arterial oxygen tension predicted by MIGET and that actually measured (P-M Pa,O2, average 0.9 kPa). During O2 breathing, P-M Pa,O2 became negative, (average -12.2 kPa), and shunt estimated by the O2 method (% of Q') was consistently less than that measured by MIGET. Whereas both O2 method and MIGET estimates of shunt never exceeded 25%, the WBS shunt was 40%, indicating that a substantial fraction of cardiac output flowed through abnormally dilated pulmonary vessels, some of which were exposed to alveolar gas and, hence, participated in gas exchange. Although our observations pertain to one subject, we believe they provide the most convincing in vivo evidence to date that abnormal dilatation of interalveolar vessels may, per se, result in a significant diffusion impairment for O2. Furthermore, in view of the consistently negative P-M Pa,O2 observed during oxygen breathing, we speculate that such abnormal vascular dilatation may also have produced a significant diffusive impairment of one or more of the less soluble inert gases used in the MIGET analysis.
Indications for the Performance of Intracranial Endovascular Neurointerventional Procedures
Authors: Philip M. Meyers, H. Christian Schumacher, Randall T. Higashida, Stanley L. Barnwell, Mark A. Creager, Rishi Gupta, Cameron G. McDougall, Dilip K. Pandey, David Sacks, Lawrence R. Wechsler
Journal: Circulation (2009)

The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel.Specifically, all members of the writing group are required to complete and
Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young Men
Authors: Amir Tirosh, Iris Shai, Dorit Tekes-Manova, Eran Israeli, David Pereg, Tzippora Shochat, Ilan Kochba, Assaf Rudich
Journal: New England Journal of Medicine (2005)

The normal fasting plasma glucose level was recently defined as less than 100 mg per deciliter (5.55 mmol per liter). Whether higher fasting plasma glucose levels within this range independently predict type 2 diabetes in young adults is unclear.
Impact of Feedback and Didactic Sessions on the Reporting Behavior of Upper Endoscopic Findings by Physicians and Nurses
Authors: Adil A. Abdalla, Bret T. Petersen, Beverly J. Ott, Mary Fredericksen, Cathy D. Schleck, Alan R. Zinsmeister, Kassandra M.J. Grunewald, Teresa Zais, Yvonne Romero
Journal: Clinical Gastroenterology and Hepatology (2007)
<i>JAK2</i> GGCC haplotype in <i>MPL</i> mutated myeloproliferative neoplasms
Authors: Daniela Pietra, Ilaria Casetti, Matteo C. Da Vià, Chiara Elena, Chiara Milanesi,, Elisa Rumi
Journal: American Journal of Hematology (2012)

JAK2 (V617F) is associated with a genetic predisposition to its acquisition,as it is preferentially found in subjects with a common constitutional JAK2 haplotype known as 46/1 or GGCC. A recent study suggests that a genetic predisposition to acquisition of MPL mutation may exist in sporadic patients, since an association was found with the JAK2 46/1 haplotype. We genotyped 509 patients with myeloproliferative neoplasms (MPN), 7% of which carrying a somatic mutation of MPL Exon 10. We found that the JAK2 GGCC haplotype was closely associated with JAK2 (V617F) (OR 1.84, P < 0.001) but not with MPL mutations (OR 0.98), suggesting a different genetic background for these molecular lesions.
A 69-Year-Old Woman With Left Main Coronary Artery Disease
Authors: Joseph P. Carrozza
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diversity and plasticity of self recognition during the development of multiple sclerosis.
Authors: V K Tuohy, M Yu, B Weinstock-Guttman, R P Kinkel
Journal: Journal of Clinical Investigation (1997)

Recent studies using murine animal model systems indicate that clinical progression of autoimmune disease may be due to the sequential accumulation of neoautoreactivity characterized by extensive plasticity of self recognition. In the present study, we addressed the question of whether a similar paradigm of self recognition is implicated in the development of multiple sclerosis (MS), a demyelinating disease with a presumed autoimmune etiology. Our approach was to determine serial changes over a 12-18-mo period in response to an epitope-mapping series of 265 12-mer peptides of myelin proteolipid protein (PLP) by patients with isolated monosymptomatic demyelinating syndromes (IMDS), a group of distinct clinical disorders with variable rates of progression to MS. Our data showed that an extensive array of proteolipid protein peptides could elicit autoreactivity. Moreover, differential autoreactive patterns were evident within IMDS patient subpopulations. Monocentric monophasic IMDS patients with no evidence of prior subclinical disease typically showed fully sustained autoreactivity characterized by extensive plasticity, epitope focusing, shifting, and spreading of responses to new self determinants. In contrast, multicentric monophasic IMDS patients with putative evidence of prior asymptomatic lesion formation typically showed partially sustained autoreactivity characterized by abrupt abrogation of responses to an extensive array of self determinants. No sustained autoreactivity was observed in normal control subjects or in patients with other neurologic diseases. Our results indicate that self recognition associated with the development of MS is a developmental process characterized by autoreactive diversity, plasticity, and instability.
Effect of Immunosuppressive Therapy on HBsAg-Positive Chronic Active Hepatitis in Relation to Presence or Absence of HBeAg and Anti-HBe
Authors: Evangelista Sagnelli, Felice Piccinino, Giuseppe Manzillo, Francesca M. Felaco, Pietro Filippini, Giuseppe Maio, Giuseppe Pasquale, Crescenzo M. Izzo
Journal: Hepatology (2007)

Two hundred and four patients with biopsy-proven HBsAg-positive chronic active hepatitis were treated for at least 2 years with azathioprine, prednisolone or a combination of both, or were untreated. Prevalences of HBeAg, anti-HBe, and anti-HBc were 26, 58, and 100%, respectively. Criteria for improvement or progression of disease were based on clinical, biochemical, and morphologic parameters. Prednisolone therapy and combination therapy did not modify the course of the disease in HBeAg-positive patients; azathioprine therapy may have been deleterious for these patients. Among HBeAg-negative patients, deterioration or death occurred more frequently in those who were untreated than in those who received the combination of azathioprine and prednisolone. Prednisolone therapy was of moderate effect, whereas azathioprine did not influence the outcome.
Epidemiology of Benign Breast Lesions: Lack of Association with Oral Contraceptive Use
Authors: Philip E. Sartwell, Federico G. Arthes, James A. Tonascia
Journal: New England Journal of Medicine (1973)

Women with benign breast lesions were compared with matched hospital controls to determine epidemiologic features and use of oral contraceptives and estrogens. There were 306 patients with cystic disease and related conditions, 71 with fibroadenoma and 39 with miscellaneous other lesions. In the cystic-disease group there was a deficit of postmenopausal women and women whose first pregnancy was under age 25. A history of use of oral contraceptives or estrogens was given no more frequently by patients with cystic disease and fibroadenoma than by their respective controls. Fewer patients with cystic disease (14) than controls (34) had used oral contraceptives for more than one year. These findings imply that use of oral contraceptives or estrogens has no role in the occurrence of benign breast neoplasms. The reproductive histories of patients with benign and malignant breast neoplasms appear similar in some respects.
Monoaminergic neurotransmission is altered in hepatitis C virus infected patients with chronic fatigue and cognitive impairment
Authors: K Weissenborn, J C Ennen, M Bokemeyer, B Ahl, U Wurster, H Tillmann, C Trebst, H Hecker, G Berding
Journal: Gut (2006)

The majority of patients with hepatitis C virus (HCV) infection suffer from disabling fatigue, cognitive dysfunction, and quality of life reduction. Meanwhile, there is increasing evidence that HCV infection can affect brain function. Recent studies have shown that fatigue and psychomotor slowing may resolve in patients with hepatitis C after treatment with ondansetron. This observation indicates alteration of serotonergic neurotransmission in HCV infected patients with chronic fatigue.Data from 20 HCV infected patients who were referred to our clinic because of disabling fatigue and cognitive decline of unknown cause were analysed retrospectively. Patients had undergone a diagnostic programme, including clinical and psychometric examination, electroencephalogram (EEG), magnetic resonance imaging of the brain, cerebrospinal fluid analysis, and I-123-beta-CIT (2beta-carbomethoxy-3-beta-(4-[(123)I]iodophenyl)tropane) single photon emission computerised tomography (SPECT) studies of serotonin and dopamine transporter binding capacity.All patients had pathological results on the fatigue impact scale. Two thirds of patients showed pathological attention test results. EEG, magnetic resonance imaging, and cerebrospinal fluid analysis were normal. Pathological dopamine transporter binding was present in 12/20 (60%) patients and pathological serotonin transporter binding in 8/19 (50%) patients. Patients with normal SPECT results did not significantly differ from controls with regard to psychometric test results. Interestingly, patients with both decreased serotonin and dopamine transporter binding showed significantly impaired performance in most of the tests applied. Comorbidity that could have impaired cerebral function was excluded in all patients.Our findings indicate alteration of serotonergic and dopaminergic neurotransmission in HCV infected patients with chronic fatigue and cognitive impairment.
Gravity inversion boots--a potential hazard
Authors: R. M. Klatz, R. M. Goldman
Journal: British Journal of Sports Medicine (1983)

Measures in Minutes3 4Pbt-kinion * Sigriatly higher than pmeusiwn keeWs (p<0C0).No sjndficant changes wer found between p-and paet-mversion.Intra-ocular pressure also rose in a similar fashion, on average from 20 mm Hg to 35 mm (Fig. 3).35 30 25 20.0 2 Pre-inversion Inversion Period Measured in Minutes 3 4 Post-inversion 0 2 3 Pre-inversion Inversion Period Measured in Minutes* Significantly different (pycOO1) from both pre-inversion and postvinversionNo differences were found between pre-and post-inversion values.* Significantly higher than preinversion levels (pC-00).No significant changes were found between pre-and postinversion.
Antemortem Donor Bilateral Nephrectomy: A Violation of the Patient's Best Interests Standard
Authors: Thomas M. Wertin, Mohamed Y. Rady, Joseph L. Verheijde
Journal: The American Journal of Bioethics (2012)

Click to increase image sizeClick to decrease image size Acknowledgments The opinions expressed here are those of the authors and do not reflect the position or policy of the Uniformed Services, Military Health System or US Department of Defense.
Survival differences among women with newly diagnosed stage IV and recurrent breast cancer.
Authors: S Dawood, B Kristine, GN Hortobagyi, S Giordano
Journal: Cancer Research (2009)

Abstract Abstract #2077 Background &amp;#x2028; The objective of this retrospective study was to determine whether differences in survival exist between women with newly diagnosed stage IV disease and those with recurrent breast cancer.&amp;#x2028; Methods&amp;#x2028; Women with newly diagnosed stage IV disease or recurrent breast cancer with distant metastases diagnosed between 1992 and 2007 were identified from the Breast Cancer Management System Database at UTMDACC. Among women with recurrent breast cancer, distant disease-free interval (DDFI) was defined as the time from diagnosis of primary breast cancer to the date of the first distant metastases. For all patients, overall survival (OS) was measured from the date of first distant metastases to the date of death from any cause or last follow-up. The Kaplan-Meier product limit method was used to estimate OS, and OS was compared across groups using log-rank statistic. Cox-proportional hazards models were fit to determine the association between stage IV breast cancer (recurrent versus newly diagnosed) and OS after controlling for other patient and tumor characteristics.&amp;#x2028; Results&amp;#x2028; The analysis included 3524 patients of whom 643 (18.2%) had newly diagnosed disease and 2881 (81.8%) had recurrent disease. Median follow-up was 19 months. Median OS among patients with newly diagnosed stage IV disease and recurrent disease was 39.2 and 27.2 months, respectively (p&amp;lt;0.0001). Patients with recurrent disease with DDFI &amp;lt; 5 years had worse OS compared to those with newly diagnosed disease (p&amp;lt;0.0001). Patients with DDFS &amp;gt;5years had better OS compared to those with newly diagnosed stage IV disease (p&amp;lt;0.005). In the multivariable model patients with recurrent disease had an increased risk of death compared to patients with newly diagnosed stage IV disease (HR=1.75, 95% CI 1.47-2.08, p&amp;lt;0.0001). When the multivariable model was stratified by DDFI, patients with recurrent disease with DDFI &amp;lt;5 years had 1.74 times the risk of death compare to those with newly diagnosed stage IV disease (95% CI 1.44-2.10, p&amp;lt;0.0001). The risk of death was not statistically different among patients with recurrent disease with DDFI &amp;gt;5 years compared to those with newly diagnosed stage IV disease (HR=1.11, 95% CI 0.88-1.41, p=0.38).&amp;#x2028; ConclusionThis large cohort study provides further insight into the natural history of recurrent and newly diagnosed stage IV breast cancer. Compared to women with newly diagnosed stage IV disease, those with recurrent disease whose DDFI was &amp;gt;5 years and &amp;lt;5 years had similar and worse OS respectively. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 2077.