tbuckley/cabot-search huggingface dataset:
TCT-736 Interim results of the JUPITER Registry on long-term performance and safety of the Transapical JenaValve
Authors: Stephan Ensminger, Utz Kappert, Ulrich Franke, Ardawan Rastan, Hendrik Treede, Florian Rueter, Walter Eichinger, Rudiger Lange, Thomas de Kroon, Friedhelm Beyersdorf, Olaf Wendler
Journal: Journal of the American College of Cardiology (2013)
Some Phases of the Problem of Smoking and Lung Cancer
Authors: Clarence C. Little
Journal: New England Journal of Medicine (1961)

MY object in discussing the subject of smoking in relation to lung cancer is quite different from that of Dr. Wynder. His purpose is to present data that have convinced him that smoking is a major — perhaps the major — cause of lung cancer. This he has done before many groups over a period of years. He does so with complete conviction and with enthusiasm. He professes little interest in the broad question of lung-cancer etiology outside smoking whereas the fact that the disease develops in non-smokers as well as in smokers seems of basic significance to me. One . . .
Torsion of the Normal Fallopian Tube Complicating Pregnancy
Authors: Renwick K. Caldwell
Journal: New England Journal of Medicine (1949)

BECAUSE torsion of the normal fallopian tube is a rare complication of pregnancy, the following case is added to those already on record.Mrs. J. B., a 23-year-old primigravida, was admitted to the hospital on July 30, 1948. Eleven days previously she experienced her first attack of pain in the right anterior portion of the abdomen. This pain began without a known precipitating cause, had no localizing signs or symptoms and disappeared when the patient remained in the upright position for 20 minutes. After this episode and until 2 days before admission, the pain recurred daily, appearing occasionally in the . . .
Can it work? Does it work? Is it worth it?
Authors: B. Haynes
Journal: BMJ (1999)

funding needs to be available for planning, implementing, and evaluating these projects. 14ithin the framework of community development, preventive health measures can be introduced into dam projects without detracting from their economic and agricultural benefits while increasing their overall benefits.The measures need to be simple, inexpensive, and involve community participation with the use of local staff and facilities.A combination of malaria control measures which incorporate local knowledge and fit local circumstances are more likely to succeed than following global recipes.Thus governments and aid agencies need to make a policy commitment to minimise the adverse health risks of dam projects by adopting an integrated package of environmental management strategies for vector control and effective public health interventions as part of community development activities.
Congenital Deficiency of Nitric Oxide Synthase 2 Protects Against Endotoxin-Induced Myocardial Dysfunction in Mice
Authors: Roman Ullrich, Marielle Scherrer-Crosbie, Kenneth D. Bloch, Fumito Ichinose, Hiroshi Nakajima, Michael H. Picard, Warren M. Zapol, Zenaide M. N. Quezado
Journal: Circulation (2000)

Background —Sepsis can be complicated by severe myocardial dysfunction and is associated with increased nitric oxide (NO) production by inducible NO synthase (NOS2). To investigate the role of NOS2 in endotoxin-induced myocardial dysfunction in vivo, we studied wild-type and NOS2-deficient mice. Methods and Results —Serial echocardiographic parameters of myocardial function were measured before and at 4, 7, 16, and 24 hours after an endotoxin challenge. Seven hours after challenge with either endotoxin or saline, systemic and left ventricular pressures were measured, and the first derivative of left ventricular developed pressure (dP/dt), slope of the end-systolic pressure–dimension relationship (Slope LVESPD ), and time constant of isovolumic relaxation (τ) were calculated. Endotoxin challenge in wild-type mice decreased left ventricular fractional shortening, velocity of circumferential shortening, dP/dt max , Slope LVESPD , and dP/dt min and increased time constant τ. Endotoxin-induced myocardial dysfunction was associated with increased ventricular NOS2 gene expression and cGMP concentrations. Seven hours after endotoxin challenge, NOS2-deficient mice had greater fractional shortening, dP/dt max , and Slope LVESPD than did endotoxin-challenged wild-type mice. Measures of diastolic function, dP/dt min and time constant τ, were preserved in endotoxin-challenged NOS2-deficient mice. After endotoxin challenge in wild-type mice, early (3-hour) inhibition of NOS2 with l - N 6 -(1-iminoethyl)lysine hydrochloride prevented, whereas later (7-hour) inhibition could not reverse, endotoxin-induced myocardial dysfunction. Conclusions —These results suggest that NOS2 is required for the development of systolic and diastolic dysfunction in murine sepsis.
Companion Encyclopedia of the History of Medicine
Authors: J Gabbay
Journal: BMJ (1994)

Ed W F Bynum, Roy Porter Routledge, £150, pp 1806 ISBN 0-415-04771-4

We should not ignore our history, but how can we learn about it when there is so much other pressure on our time? One of the most frustrating things about the history of medicine is the lack of any single overview that does the subject justice. The standard books that usually sit at the dusty end of the library do all the things that the modern historian abhors: they pluck medicine out of its social and historical context as if it had an existence separate from the people who engaged in it. They selectively glorify those aspects of the past that we now approve of even if they were irrelevant in …
Mental disorders in the developing world
Authors: L W Dunn, T O Adebowale, C Umapthy, I B Chaudry, S D Yangye, Y A Rahimi, R Omoigui, D Dighi-Deo, M N Siddiqi, P U Ikwuagwu, G Festumberhan, J A Ngowi, O Olayinka, D H Pepple, F M Ibitoye, O Obikoya
Journal: BMJ (1994)

EDITOR, - The issues raised by Melanie Abas and Jeremy Broadhead, particularly the suggestion about the use of local resources in developing intervention programmes, are relevant to mental health care delivery in the developing world.

Many developing countries, however, have other major health problems related to poverty and ignorance, …
Left Ventricular Thrombus
Authors: Imran Chaudry, Vasco Marques, Robert J. Ruffner
Journal: Circulation (1998)

A 37-year-old white man with a past medical history of mental retardation, hypertension, and insulin-dependent diabetes mellitus was admitted to a regional hospital with uncontrolled hypertension, nausea, and vomiting.Two days after admission, the patient developed ischemia in the right lower extremity, for which he underwent right femoral embolectomy.An echocardiogram revealed regional wall motion abnormalities and a large, loose thrombus in the left ventricular cavity, as shown in the figure .A coronary angiogram showed three-vessel disease.The patient subsequently underwent coronary artery bypass graft surgery and removal of the thrombus from the left ventricle.He was discharged on day 7 after surgery in stable condition.
Training for Obstetrics and Gynaecology
Authors: C. H. G. Macafee
Journal: BMJ (1967)

sory or perceptual changes.Will a flexible " law " forbid the possession of any drugs at all without a prescription ?There might be something to be said for this, whereas for the present policy of changing the law, or designating secret and in fact non-existent treatment centres, there is absolutely nothing to be said.It is time to examine comprehensively the attitude of our society to the flood of new chemicals that it is itself calling into exist- ence.What new kinds of drug action do we need ?If we will only specify them, our inventive and resourceful pharmaceutical industry is very likely to produce them.Meanwhile, it is apparent that we need hallucinogens, for they are what we are getting.Why ?We need scientific answers, not guesses themselves based on fantasies.Perhaps we should begin by asking that our legislators recognize this as the kind of ques- tion that matters, and that not until we have tried to answer it scientifically can there be any reasonable basis for changing the law, whether in the direction of increased flexibility or the reverse-I am, etc.,
Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B lymphoblastoid cell line.
Authors: M A Kennedy
Journal: The Journal of Experimental Medicine (1991)

The chromosome breakpoints of a translocation, t(2;14), from an Epstein-Barr virus-transformed human B lymphoblastoid cell line were isolated and analyzed. This unusual translocation arose as a result of the fusion of two immunoglobulin (Ig) variable (V) genes, one from the heavy chain cluster on chromosome 14, the other from the light chain (k) cluster on chromosome 2. The chromosome breaks occurred within the coding sequence of each gene, and there was no obvious evidence for lymphoid V(D)J recombinase involvement in the translocation. This suggests that breakage and rejoining of the involved V genes occurred by some process other than that which normally rearranges Ig genes.
Letter: Colour disturbance as a symptom.
Authors: A G Freeman
Journal: BMJ (1975)

with the same antigen since our source of material is the same.Hopefully, co-operative and collaborative efforts will accelerate the eventual realization of an effective human vaccine to protect against malaria.The pro- cess of achieving this end should not be exacerbated by deliberate or inadvertent downgrading or misrepresen,tation.
An analysis of the pacing strategy adopted by elite competitors in 2000 m rowing
Authors: S W Garland
Journal: British Journal of Sports Medicine (2004)

To determine the pacing strategies adopted by elite rowers in championship 2000 m races.Split times were obtained for each boat in every heavyweight race of the Olympic Games in 2000 and World Championships in 2001 and 2002, and the top 170 competitors in the British Indoor Rowing Championships in 2001 and 2002. Data were only included in subsequent analysis if there was good evidence that the athlete or crew completed the race in the fastest possible time. The remaining data were grouped to determine if there were different strategies adopted for on-water versus ergometer trials, "winners" versus "losers", and men versus women.Of the 1612 on-water race profiles considered, 948 fitted the inclusion criteria. There were no differences in pacing profile between winners and losers, and men and women, although on-water and ergometry trials showed a competitively meaningful significant difference over the first 500 m sector. The average profile showed that rowers performed the first 500 m of the race faster than subsequent sectors-that is, at a speed of 103.3% of the average speed for the whole race, with subsequent sectors rowed at 99.0%, 98.3%, and 99.7% of average speed for on-water rowing, and 101.5%, 99.8%, 99.0%, and 99.7% for ergometry.These data indicate that all athletes or crews adopted a similar fast start strategy regardless of finishing position or sex, although the exact pace profile was dependent on rowing mode. This strategy should be considered by participants in 2000 m rowing competitions.
Phosphorylated 4E-BP1 Is Associated with Poor Survival in Melanoma
Authors: Kathryn E. O'Reilly, Melanie Warycha, Michael A. Davies, Vanessa Rodrik, Xi K. Zhou, Herman Yee, David Polsky, Anna C. Pavlick, Neal Rosen, Nina Bhardwaj, Gordon Mills, Iman Osman
Journal: Clinical Cancer Research (2009)

Both phosphatidylinositol 3-kinase/AKT and RAS/mitogen-activated protein kinase signal transduction pathways mediate 4E-BP1 phosphorylation, releasing 4E-BP1 from the mRNA cap and permitting translation initiation. Given the prevalence of PTEN and BRAF mutations in melanoma, we first examined translation initiation, as measured by phosphorylated 4E-BP1 (p-4E-BP1), in metastatic melanoma tissues and cell lines. We then tested the association between amounts of total and p-4E-BP1 and patient survival.Seven human metastatic melanoma cells lines and 72 metastatic melanoma patients with accessible metastatic tumor tissues and extended follow-up information were studied. Expression of 4E-BP1 transcript, total 4E-BP1 protein, and p-4E-BP1 was examined. The relationship between 4E-BP1 transcript and protein expression was assessed in a subset of patient tumors (n = 41). The association between total and p-4E-BP1 levels and survival was examined in the larger cohort of patients (n = 72).4E-BP1 was hyperphosphorylated in 4 of 7 melanoma cell lines harboring both BRAF and PTEN mutations compared with untransformed melanocytes or RAS/RAF/PTEN wild-type melanoma cells. 4E-BP1 transcript correlated with 4E-BP1 total protein levels as measured by the semiquantitative reverse-phase protein array (P = 0.012). High levels of p-4E-BP1 were associated with worse overall and post-recurrence survival (P = 0.02 and 0.0003, respectively).Our data show that translation initiation is a common event in human metastatic melanoma and correlates with worse prognosis. Therefore, effective inhibition of the pathways responsible for 4E-BP1 phosphorylation should be considered to improve the treatment outcome of metastatic melanoma patients.
Urinary Concentrations of 2,4-Dichlorophenol and 2,5-Dichlorophenol in the U.S. Population (National Health and Nutrition Examination Survey, 2003–2010): Trends and Predictors
Authors: Xiaoyun Ye, Lee-Yang Wong, Xiaoliu Zhou, Antonia M. Calafat
Journal: Environmental Health Perspectives (2014)

2,4-Dichlorophenol (2,4-DCP), 2,5-dichlorophenol (2,5-DCP), and their precursors are widely used in industry and in consumer products. Urinary concentrations of these dichlorophenols (DCPs) have been measured as part of four National Health and Nutrition Examination Survey (NHANES) cycles in order to assess the exposure to these compounds or their precursors among the general U.S. population.
Antibody directed to determinants of a Moloney virus derived MCF GP70 recognizes a thymic differentiation antigen.
Authors: D A Johnson, J H Elder
Journal: The Journal of Experimental Medicine (1983)

We prepared an antiserum to a 14-amino-acid-long synthetic peptide derived from the published nucleotide sequence of a Moloney virus-derived MCF recombinant virus. This peptide is not found in the parental Moloney virus gp70 sequence or in other ecotropic viruses so far sequenced. When several tissues of the mouse were examined by Western blot analysis for related molecules, we found that thymocytes from 2-3-mo-old mice, but not splenic T cells or bone marrow cell extracts reacted with this probe. We found that the Mr 70,000 thymic glycoprotein recognized by the anti-peptide antiserum (81-TAg) was present at equivalent levels on peanut agglutinin positive thymocytes in all mouse strains tested. These results indicate that 81-TAg is a differentiation antigen that is related to the substituted portion of an MCF retrovirus.
The effects of tai chi class on subjective exercise experiences: a preliminary study in community sports centre settings
Authors: S Baltsezak, G Dilliway
Journal: British Journal of Sports Medicine (2011)

Background Exercise Referral Schemes (ERS) are aimed at local residents to encourage them to become physically active. General practitioners use ERS when they feel their patients can benefit from organised physical activity. Subjective psychological states that occur during and after exercise are likely predictors of whether individuals are willing to adopt and maintain lifestyles that include physical activity. Therefore if Tai Chi (TC) class improves psychological affect it could be included in the range of physical activities offered to the scheme participants. Objective This study examines short term effects of TC class on subjective well being of patients referred to ERS. Design Within subject comparison of changes in a pre-test post-test design. Interventions Subjective Exercise Experiences (SEES) were measured by validated questionnaire before and after the TC class. TC class consisted of warm up (10 min), learning TC techniques (25 min), performing Yang style eight steps form (7 min), and cool down (3 min). Brief Physical Activity and rate of perceived exertion (RPE) were also recorded by validated questionnaires. Setting Community Sports centre. Participants 13 TC-naive volunteers (mean age 47) were recruited via ERS. Results Mean RPE after TC class was 12.31 with 95% CI 10.7 to 13.8. Mean score for Positive well being improved from 15.1 to 20.5 (P-value 0.004), Mean score for Psychological distress decreased from to 12.7 to 9.4 (P-value 0.080), scores for Fatigue also decreased from 14.4 to 12.2 (P-value 0.21). Even though mean SEES scores showed improvements in all three categories, only improvements in Positive well being was very statistically significant. Conclusion This is the first study in the UK exploring psychological effects of TC on people taking part in ERS. The results demonstrate psychological benefits after participating in a single TC class. TC can be included in the range of physical activities offered by ERS.
Penile Prosthesis: Potential Value of Medical Psychiatric Assessment and Psychotherapy
Authors: Thomas D. Stewart
Journal: Psychotherapy and Psychosomatics (1985)

Impotence is often the expression of complex psychological and physiological dysfunction. Proper medical psychiatric assessment is essential to assure that treatment addresses the real problems. Advances in materials technology and surgical methods have made penile implants an increasingly popular solution for impotence. There are, however, other treatments which may provide relief. These include correction of endocrine dysfunction, change in medications, and psychotherapy. This article reviews the content of a proper medical work-up, prosthesis options, psychiatric assessment, and psychotherapeutic considerations in addressing this problem.
Focal Calcification of Heart Muscle; Case Report
Authors: VINCENT DE PAUL KING
Journal: Annals of Internal Medicine (1929)

Article1 March 1929Focal Calcification of Heart Muscle; Case ReportVINCENT DE PAUL KING, M.D.VINCENT DE PAUL KING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-9-936 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCalcium may be deposited within the cardiac tissue or precipitated directly into the endocardium. Healthy tissue never shows calcium salts deposited. Deposition of the calcium salts in dead or deteriorated tissue, however, is not very uncommon. (1) At first the process consists of a deposition of fine calcium granules, usually phosphates, within the broken up heart muscle fibers. These calcium granules may then coalesce, forming plaques, the latter gradually involving all elements of the heart substance. Scholtz (2) points out that there is no specific cause for this condition but that calcification can occur in the course of any pathological...References(1) CULLEN EK: So-called spontaneous focal myocarditis and the occurrence of calcification of the degenerate muscle fibrils. Johns Hopkins Hospital Bulletin, August, 1906, Vol. 17, p. 267. Google Scholar(2) SCHOLTZ T: Calcification of the heart; its roentgenological demonstration; review of the literature and theories on myocardial calcification. Arch. Int. Med. 34:32:1924. CrossrefGoogle Scholar(3) CASE JT: Pericarditis Calculosa. J. A. M. A. 80:236:1923. CrossrefGoogle Scholar(4) CUTLERSOSMAN ECMC: Calcification in heart and pericardium. American Journal Roentgenol. 12:312:1924. Google Scholar(5) WELLS HG: The pathology of the healed fibrous adhesions of the pericardium. Am. J. Med. Sc. 123:241:1902. CrossrefGoogle Scholar(6) WALDROP CP: Calcified nodules in bundle of His. Rev. Assoc. Med. Argent. 37:74:1924. Google Scholar(7) SCHOLTZ T: Radiographic demonstration of calcification of myocardium during life. J. Radiol. 5:131:1924. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memphis, Tennessee PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1929Volume 2, Issue 9Page: 936-940KeywordsCalciumCardiac musclesEndocardiumHeartMyocardiumPhosphatesSalts ePublished: 1 December 2008 Issue Published: 1 March 1929 PDF downloadLoading ...
A NEW COMBINED OPERATING AND OFFICE TABLE.
Authors: JOHN H. DOWNEY
Journal: JAMA (1906)

I have devised a new combination operating, office and fracture table, in which I have tried to arrange the traction in every desired direction that will hold the patient in a partially suspended and yet comfortable position. It gives the physician free access to his patient and allows him to apply a dressing or a plasterof-Paris splint to any part of the body. In Figure 1, the table is arranged for general surgery; it is just as good as any for general operating and can be easily arranged for office work. By dropping the lower portion of the top and placing the leg rests and stirrups in position it can be used for special operations about the vagina, uterus or rectum. Figure 2, shows the arrangement for treatment of fracture of the femur or fracture of the upper two-thirds of the tibia and fibula. In the latter the whirl arch
GASTROSTOMY BY A CIRCULAR VALVE METHOD.
Authors: EMANUEL J. SENN
Journal: JAMA (1896)

Gastrostomy, since it was first suggested by Egeberg in 1837 and performed by Sedillot in 1849, has undergone many transformations in the evolution of technique. The primitive operations as done by Sedillot, Fenger, Foster, Durham, Langenbeck, Krönlein and Verneuil, consisted simply in making the external incision through the abdominal wall and fastening the stomach in the wound with sutures or steel needles as a support, and then incising it. There naturally was no resistance to the stomach contents, the great obstacle to gastrostomy. The operation fell into ill repute and practically lay dormant until the present decade, when it was revived and received an impetus in the modern methods of Von Hacker, Hahn, Witzel, Ssabanajew and Frank, in the hope of rectifying the disagreeable features that are inevitable in a continual leakage of a gastric fistula. It is rather strange when we compare the great mortality attendant upon gastrostomy with