Heparin-Associated Thrombosis Without Thrombocytopenia
Authors: BRIAN K. PHELAN
Journal: Annals of Internal Medicine (1983)

Brief Reports1 November 1983Heparin-Associated Thrombosis Without ThrombocytopeniaBRIAN K. PHELAN, M.D.BRIAN K. PHELAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-5-637 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHeparin-associated thrombocytopenia is a recognized syndrome characterized by persistent thrombocytopenia after heparin administration and the occurrence of arterial thrombosis ( 1 ). The following case report shows that the thromboembolic complications can occur with normal absolute platelet counts as well.A 64-year-old woman had intra-aortic balloon insertion and right coronary angioplasty for unstable angina with a 90% right coronary artery occlusion. A nontransmural inferior infarction occurred after angioplasty. The patient had a superior mesenteric artery embolus requiring continuous-infusion heparin, 1000 U/h, as a result of the balloon pump. A massive transmural extension of her previous infarct occurred on day 7...References1. WEISMAN R and TOBIN R. Arterial embolism occurring during systemic heparin therapy. Arch Surg. 1958;76:219-27. CrossrefGoogle Scholar2. KELTON J and POWERS P. Heparin associated thrombocytopenia: an immune disorder. In: LUNDLAND RL, BROWN WV, MANN KG, ROBERTS HR, eds. Chemistry and Biology of Heparin. New York: Elsevier/North Holland; 1981:365-80. Google Scholar3. KAPSCH D, ADELSTEIN E, and SILVER D. Heparin induced thrombocytopenia. In: LUNDLAND RL, BROWN WV, MANN KG, ROBERTS HR, eds. Chemistry and Biology of Heparin. New York: Elsevier/North Holland; 1981:357-64. Google Scholar4. COLMAN R and SCHREIBER A. Effects of heterologous antibody on human platelets. Blood. 1976;48:119-31. CrossrefMedlineGoogle Scholar5. SABA H, SABA S, BLACKBURN C, HARTMAN R, and MASON R. Heparin neutralization of PGI2: effect upon platelets. Science. 1979-205-449-501. CrossrefMedlineGoogle Scholar6. HUSSEY C, BERNHARD V, MCLEAN M, and FOBIAN J. Heparin induced platelet aggregation: in vitro confirmation of thrombotic complications associated with heparin therapy. Ann Clin Lab Sci. 1979;9:487-93. MedlineGoogle Scholar7. BYGDEMAN S. Prevention and therapy of thromboembolic complications with dextran. Prog Surg. 1969;7:114-39. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BRIAN K. PHELAN, M.D.Affiliations: North Carolina Memorial Hospital University of North Carolina Chapel Hill, North Carolina. 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VADER, M.D. 1 November 1983Volume 99, Issue 5Page: 637-638KeywordsAngioplastyCoronary angioplastyHeparinInfarctionMesenteric arteriesPlateletsRight coronary arteryThrombosisUnstable angina ePublished: 1 December 2008 Issue Published: 1 November 1983 PDF downloadLoading ...