tbuckley/cabot-search huggingface dataset:
How do Physicians Think about Successful Aging?
Authors: Lauren Snow, Cynthia X. Pan
Journal: Annals of Internal Medicine (2004)

Letters18 May 2004How do Physicians Think about Successful Aging?Lauren Snow, BA and Cynthia X. Pan, MDLauren Snow, BAFrom Mount Sinai School of Medicine, New York, NY 10029.Search for more papers by this author and Cynthia X. Pan, MDFrom Mount Sinai School of Medicine, New York, NY 10029.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-10-200405180-00030-w1 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the supplement to the 2 September 2003 issue focused on successful aging (1). The articles dealt with various aspects of successful aging, including death and dying and a definition of successful aging that is not based primarily on longevity. One issue that was not addressed was how physicians themselves think about successful aging. Physicians' perception and frame of mind about successful aging probably affect the direction of patient care. We would like to share the results of our pilot study exploring how physicians think about successful aging.Physicians at our hospital in internal ...References1. Callahan CM, McHorney CA, Mulrow CD. Determinants of Successful Aging: Developing an Integrated Research Agenda for the 21st Century. Ann Intern Med.; 2003;139(5 Part 2):389-462. Google Scholar2. Rowe JW, Kahn RL. Successful Aging. New York: Random House; 1998. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Mount Sinai School of Medicine, New York, NY 10029. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSuccessful Aging and the Humility of Perspective Christopher M. Callahan and Colleen A. McHorney Successful Aging and the Humility of Perspective Christopher M. Callahan and Colleen A. McHorney Metrics Cited byThe Cultural Context of “Successful Aging” Among Older Women Weavers in a Northern Okinawan Village: The Role of Productive ActivityPhysician hearing loss 18 May 2004Volume 140, Issue 10Page: W-37KeywordsAgingDietElderlyGeriatricsHospital medicinePatientsPerceptionPilot studiesQuestionnaires ePublished: 18 May 2004 Issue Published: 18 May 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Quick fixes for research assessment exercise will not work
Authors: S. S. Leger
Journal: BMJ (2000)

EDITOR—Tomlinson challenges those who seek to abandon the research assessment exercise to propose a credible alternative for the accountable allocation of public money.1 Goldbeck-Wood quotes a patients' spokesman, Clive Wilkinson, as saying, “The public understands that research is essential; but it needs to be on their terms—not on the basis of what is comfortable to academics.”2

The research assessment …
Abstract 2961: The N-terminal projection domain of the microtubule associated protein tau inhibits TNFα signaling.
Authors: Shawon Debnath, Peter Hannon, Kristina Toropova, Nelson Nunez Rodriguez, Alejandra Alonso, Jimmie Eugene Fata
Journal: Cancer Research (2013)

Abstract Tumor Necrosis Factor-alpha (TNFα) is a multifunctional pro-inflammatory cytokine implicated in inducing both tumor promotion and tumor inhibition. This paradoxical effect can be partly explained by the fact that TNFα acts as a regulator of both proliferation and apoptosis; however the mechanisms and factors associated with how or whether a tumor cell responds to a microenvironment rich in TNFα have not been fully resolved. Here we provide evidence that the microtubule associate protein Tau inhibits TNFα signaling through its N-terminal domain and implicate it as a novel regulator of the cellular response to this key cytokine. Our findings indicate that over-expression of Tau in the human breast cancer cell lines MCF7, SkBr3 and in the pheochromocytoma cell line PC12 suppresses TNFα induced apoptosis evident in the control cells. TNFα induced cell apoptosis in control cells is triggered as early as 6 hrs post-treatment with hallmark features of cell shrinkage, membrane blebbing, disruption of tubulin architecture and caspase-3 activation. While over-expression of wild type full length Tau isoform in these cell lines, completely abrogates all TNFα associated apoptotic phenotypes. Aside from inhibiting TNFα induced apoptosis, Tau over-expression also interferes with TNFα induced NFκB activation. This is evident by a significant decrease in NFκB nuclear translocation in Tau over-expressed cells compared to controls. Suppression of TNFα signaling by Tau is not associated with its tubulin interaction since a truncated N-terminal projection domain lacking all microtubule binding domains still provides resistance to TNFα induced apoptosis and NFκB activation. These findings lead us to conclude that the functional domain of Tau that regulates TNFα response lies within its N-terminal region and current mechanistic studies indicate this region inhibits TNFα receptor clustering, which is needed for signaling. Our data provide direct evidence that the N-terminal domain of the microtubule associated protein Tau can inhibit TNFα signaling in tumor cells. These findings indicate a novel function for Tau and add to our knowledge of how a tumor cell responds to TNFα signaling. Citation Format: Shawon Debnath, Peter Hannon, Kristina Toropova, Nelson Nunez Rodriguez, Alejandra Alonso, Jimmie Eugene Fata. The N-terminal projection domain of the microtubule associated protein tau inhibits TNFα signaling. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2961. doi:10.1158/1538-7445.AM2013-2961 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
SOME POINTS IN THE SURGERY OF THE URETERS.
Authors: WELLER VAN HOOK
Journal: JAMA (1895)

An interesting work on ureteral surgery 1 has recently been published in Paris. The author devotes his entire attention to anatomy; to the methods of exposing the ureter for surgical treatment; to ureterotomy for removal of calculi and for the relief of stenosis, and to resection. Inasmuch as he omits the consideration of such important branches of the subject as diagnosis, the use of catheterization of the ureters for various purposes and the implantation of the ureters upon the skin, into the intestinal tract and into the bladder, his work must be regarded as a valuable and timely discussion of the topic touched upon, but not as the systematic treatise upon the general subject of surgical ureteral diseases which the title and the size of the volume lead one to expect.  The position assumed by the present writer upon a former occasion 2 in reference to the subjects of suturing
Variceal pressure is a factor predicting the risk of a first variceal bleeding: A prospective cohort study in cirrhotic patients
Authors: Frederik Nevens, Rami Bustami, Ilse Scheys, Emmanuel Lesaffre, Johan Fevery
Journal: Hepatology (1998)

Predictive criteria for a first variceal hemorrhage lack substantial accuracy. Cross-sectional studies suggest a close relationship between variceal pressure (VP) and the occurrence of variceal bleeding. In the present prospective cohort study, the significance of VP measurement for prediction of a first variceal bleed was assessed. Eighty-seven patients with cirrhosis and large esophageal varices who had never developed variceal bleeding were followed for 12 months. The endpoint of the study was the presentation or not of a variceal hemorrhage. Thirty-four patients (39%) were in Child's class A, 37 in class B (43%), and 16 in class C (18%). The median interval between endoscopic diagnosis of varices and the beginning of the study was 15 months. Twenty-eight patients (32%) developed a variceal hemorrhage with a bleeding-related mortality of 18% (n=5). The 1-year mortality overall was 16% (n=14). Variables predictive of a first bleed identified by Cox proportional hazards regression model were: the level of VP, the North Italian Endoscopic Club (NIEC) score, and the interval between the diagnosis of varices and the start of the study. By adding VP to NIEC, a significant gain in prognostic accuracy was obtained (P = .003). In conclusion, the present study provides evidence that the level of VP is a major predictive factor for variceal hemorrhage, and that it provides further prognostic information in addition to the NIEC index.
Sorafenib in Platinum-Treated Patients with Extensive Stage Small Cell Lung Cancer: A Southwest Oncology Group (SWOG 0435) Phase II Trial
Authors: Barbara J. Gitlitz, James Moon, Bonnie S. Glisson, H. Joachim Reimers, Martin J. Bury, Justin D. Floyd, Thomas K. Schulz, P. Kothai Sundaram, Christopher Ho, David R. Gandara
Journal: Journal of Thoracic Oncology (2010)
PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia
Authors: Martin Weisser, Ru-Fang Yeh, Guillemette Duchateau-Nguyen, Giuseppe Palermo, Tri Quang Nguyen, Xiaoyan Shi, Susanna Y. Stinson, Nancy Yu, Annika Dufour, Tadeusz Robak, Galina N. Salogub, Anna Dmoszynska, Philippe Solal-Celigny, Krzysztof Warzocha, Javier Loscertales, John Catalano, Loree Larratt, Viktor A. Rossiev, Isabelle Bence-Bruckler, Christian H. Geisler, Marco Montillo, Kirsten Fischer, Anna-Maria Fink, Michael Hallek, Johannes Bloehdorn, Raymonde Busch, Axel Benner, Hartmut Döhner, Nancy Valente, Michael K. Wenger, Stephan Stilgenbauer, David Dornan
Journal: Blood (2014)
Killing Forests to Cure Tobacco
Authors: Gerald M. Bordin
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The recent issue (Feb 28, 1986) devoted to the adverse human health aspects of cigarette smoking deserves great praise. The recently revised cigarette package and advertisement warnings will educate the general public regarding the risks of lung cancer, heart disease, emphysema, premature birth, fetal injury, low (fetal) birth weight, and elevated carbon monoxide levels. Recently, Dr C. Everett Koop, US Surgeon General, has even voiced concern about the synergy between cigarette smoking and occupational hazards and has attributed 340,000 premature deaths to cigarette smoking. But it must be noted that cigarettes take a nonhuman toll as well. According to Wachtel and McNeely, tobacco utilization is responsible for a significant rate of demise of forests (<i>International Wildlife</i>, January-February 1986, p 15). In fact, they state that outside North America, an acre of forest must be burned to cure an acre of tobacco. Most frightening is the fact that
TCT-609 Incidence, diagnosis and clinical outcomes of patients with impaired coronary vasoreactivity: insights from a protocol of systematic coronary artery spasm detection over ten years.
Authors: Helene Aelion, Aures Chaib, Marie Caroline Chenilleau, Stephane Manzo-Silberman, Julien Rosencher, Emmanuel Salengro, Patrick Schiano, Alain Cariou, Simon Weber, Olivier Varenne
Journal: Journal of the American College of Cardiology (2013)
PTU-010 Perforation or Mucosal Tear- a Classical Presentation of Collagenous Colitis with Mucosal Tear
Authors: M Rajaram, S Ramasamy, K Koss
Journal: Gut (2013)

<h3>Introduction</h3> In general, the colonic mucosa is macroscopically normal in collagenous colitis, although minor, non-specific abnormalities may be found. Significant endoscopic abnormalities, «mucosal tears» representing longitudinal mucosal lacerations, have been reported in a few patients with collagenous colitis (1). The colonoscopist should aware that the risk of perforation is likely to be increased when mucosal tears are present.A 56-year-old female patient was referred to the outpatient clinic with 6 weeks history of profuse watery diarrhoea. Her significant past medical history includes colonic polyps and polypectomy in 2000 and her last colonoscopy in 2003 was normal. Her drug history includes alendronic acid 70 mg once a week, hormone replacement therapy patches, solifenacin 5 mg once a day and loperamide 2 mg as required. Her initial blood investigations including FBC, Urea &amp; electrolytes, LFT, TFT, inflammatory markers, coeliac serology &amp; stool cultures were normal. Her colonoscopy revealed a mucosal tear at the splenic flexure and the biopsies confirmed collagenous colitis. <h3>Methods</h3> N/A <h3>Results</h3> N/A <h3>Conclusion</h3> The colonoscopy usually reveals a normal mucosa or mild mucosal edoema &amp; usually biopsies required to confirm the diagnosis. The mucosal tears on endoscopic insufflation are not uncommon with collagenous colitis.A postulated mechanism for the mucosal lacerations in collagenous colitis might be the rigid character of the collagen containing subepithelium, possibly in combination with endoscopic insufflation,leading to stretching of the mucosa and subsequent tearing (2) <h3>Disclosure of Interest</h3> None Declared <h3>References</h3> Colonic mucosal tears in collagenous colitis. Wickbom A, Lindqvist M, Bohr J, Ung KA, Bergman J, Eriksson S, Tysk C.SourceDivision of Gastroenterology, Department of Medicine, Orebro University Hospital, Orebro, Sweden. Collagenous colitis with mucosal tears on endoscopic insufflation: a unique presentation. M Cruz-Correa, F Milligan, F M Giardiello, <i>et al.</i><i></i> Gut 2002 51: 600 doi:10.1136/gut.51.4.600
Radioautographic study of human pulmonary tissues
Authors: G. Kury, L. H. Rev-Kury, H. W. Carter
Journal: Thorax (1969)

The radioautograms of human lungs were studied after <i>in vitro</i> incubation with tritiated thymidine. Our materials consisted of the lungs of 12 normal foetuses (crown-rump length varied from 7·5 to 16·5 cm.) and of 11 adults (32 to 68 years of age). In the foetal lungs the uptake of tritiated thymidine was highest in the epithelium surrounding small tubular spaces, forerunners of future bronchial epithelium, and in the undifferentiated mesenchyme. The percentage of labelled cells was scarce in the alveolar wall cells of adults (0·05% to 0·65%), was unrelated to age, and appeared to be most frequent in phagocytic elements (so-called alveolar cells). There was an uptake of tritiated thymidine in scattered free alveolar macrophages and in a few interstitial cells. The media and adventitia of blood vessels did not show labelling in most cases. The labelling of epithelium of bronchioles and respiratory bronchioles varied from 0·20% to 0·70%. The findings of other investigators in the study of cell turnover in the lungs of laboratory animals are discussed and compared with the data obtained in the present study.
Quality Improvement Organizations and Hospital Care
Authors: D. W. Bratzler
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4029: Sox9 functions downstream of Hedgehog-Gli1 in epithelial transformation
Authors: Wentao Deng, J. Michael Ruppert
Journal: Cancer Research (2010)

Abstract The Sonic Hedgehog (Shh) signaling pathway plays critical roles in cell fate specification during embryonic and fetal development and in adult tissues. The extracellular morphogen, Shh, signals through Gli family zinc finger transcription factors to regulate the expression of downstream target genes. Constitutive Shh-Gli signaling is implicated in the pathogenesis of several human cancers, including cutaneous basal cell carcinoma (BCC), prostate cancer and medulloblastoma. How Gli can signal through downstream genes to induce malignant transformation remains poorly understood. In this work, we performed microarray analysis to reveal the gene expression profile after tetracycline-regulated induction of Gli1 for 3 or 6 hours in cultured epithelial cells, identifying multiple known Shh target genes. Among the most rapidly induced genes was Sox9, a member of SRY family of transcription factors. Sox9 is essential for male sex determination and is a master regulator of chondrogenesis. Sox9 is also well established as a Shh-Gli target gene, but how it functions in Shh-Gli signaling is not well understood. We found that Sox9 mRNA and protein levels are greatly increased after short-term or long-term Gli1 expression in a rat culture model of epithelial cells, termed RK3E, and in mouse skin. As shown by reporter assays, Sox9 transcriptional activity was increased by approximately 18-fold in RK3E cells transformed by Gli1. To enable knockdown studies in rat cells, we defined the full-length rat Sox9 coding sequence. Subsequently, suppression of rat Sox9 by siRNA indicated an essential role for this Gli-regulated gene in malignant transformation of RK3E in vitro. Specifically, shRNA plasmids that suppress Sox9 could dramatically reduced the transforming activity of Gli1. In contrast, there was little effect on other transforming oncoproteins including H-Ras and ErbB2. These results establish Sox9 induction as an early response to Gli1, and demonstrate that induction of Sox9 is essential for transformation by Gli1. Further characterization of the Sox9 knockdown phenotype is in progress and will be presented. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4029.
Abstract 2947: Effects of Serial Levosimendan Infusions on Left Ventricular Remodeling and Plasma Biomarkers of Myocardial Injury and Neurohormonal Activation in Patients with Advanced Heart Failure
Authors: Dimitrios Farmakis, John Parissis, Vasiliki Bistola, Fotios Panou, Christoforos Komporozos, Kaliroi Kourea, Maria Nikolaou, Gerasimos Fillipatos, Dimitrios Kremastinos
Journal: Circulation (2006)

Background: Levosimendan is a novel inodilator that improves central hemodynamics and symptoms of patients with advanced heart failure (HF). The role, however, of repeated levosimendan infusions in...
Epidemiological approach to surgical management of the casualties of war
Authors: R M Coupland
Journal: BMJ (1994)

The nature of modern conflicts precludes adequate medical care for most people wounded in wars. The traditional military approach of echeloned care for those wounded on the battlefield has limited relevance. I present an alternative, epidemiological approach whereby some effective care may reach many more. For a surgical facility to have a positive impact by using surgical and anaesthetic competence there must be access to the wounded; security for staff and patients; and a functioning hospital infrastructure. These all depend on respect for the first Geneva convention. Early hospital admission for urgent surgery is not so important if there is adequate first aid beforehand. The hospitals of the International Committee of the Red Cross have provided surgical care for thousands of wounded people by fulfilling these conditions. People wounded in modern conflicts would fare better if these priorities were recognised and less emphasis was placed on the more spectacular aspects of surgical care that benefit only a few.
REPORT OF TWO INTERESTING CASES.
Authors: W. D. TRAVIS
Journal: JAMA (1899)

<h3>PECULIAR SEQUELÆ OF MEASLES.</h3> The first case I wish to report is that of Lizzie F., a German, aged 14 months. She was taken sick September 4, and admitted to the hospital three days later with a well-defined case of measles. Her temperature being 104.2 on admission, she was given phenacetin and whisky, and for an annoying cough she was given Stokes' mixture for several days. She was convalescent three days after entrance, but it being customary to keep patients in the hospital in all cases of contagious diseases until desquamation was complete, she remained in the convalescent ward for some time. On September 26 her temperature rose rapidly to 104.4 degrees, whereupon she was promptly isolated for observation. Her gums were considerably swollen from teething, and a very discrete rose-colored macular eruption was scattered over the body, but was not perceptible the following evening, the temperature having fallen to
THE PATHOLOGIC PHYSIOLOGY OF EXPERIMENTAL GANGRENOUS PANCREATITIS
Authors: LUCIA E. TOWER
Journal: JAMA (1926)

In this paper I present a brief preliminary report of a group of experiments, the object of which was, if possible, to obtain more information concerning the causes and the nature of the violent toxemia occurring in acute hemorrhagic pancreatitis. Ultimately, it was hoped, a more rational and effective treatment of the disease might be evolved than is now generally employed.  No attempt will be made here to discuss the literature on acute pancreatitis, or to describe the clinical manifestations of the disease. For this information the reader is referred to the recent very inclusive paper by Moynihan. 1 Suffice it to say that almost every conceivable method by which the pancreas could be seriously injured has been utilized to reproduce in animals the clinical picture of acute pancreatitis; all that is necessary is that a sufficient amount of pancreatic tissue be suddenly so devitalized that an extensive necrosis and
Abstract 13172: Critical Role of ROCK2 in Bone Marrow-derived Macrophages in Mediating Atherosclerosis
Authors: Qian Zhou, James K Liao
Journal: Circulation (2010)

Background: Rho kinases (ROCKs) are serine-threonine protein kinases that are involved in the regulation of the actin cytoskeleton. Recent studies suggest that ROCKs also play a pivotal role in car...