tbuckley/cabot-search huggingface dataset:
Abstract 1235: Human antibodies specific for a novel isoform of the macrophage migration inhibitory factor are potential therapeutics for prostate cancer.
Authors: Michael Thiele, Michael Freissmuth, Filza Hussain, Patrice Douillard, Dirk Völkel, Hartmut Ehrlich, Friedrich Scheiflinger, Randolf Kerschbaumer
Journal: Cancer Research (2013)

Abstract Macrophage migration inhibitory factor (MIF) was found to be upregulated in many cancers and to act in para- and autocrine loops within the tumor microenvironment. Thereby, MIF contributes to the modulation of cytokine patterns and triggers anti-apoptotic and pro-proliferative cell signaling events. MIF was also described as a pro-angiogenic factor promoting neoangiogenesis and vascularization. In prostate cancer, MIF mRNA and protein levels were shown to be increased and to contribute to tumor development. We have discovered a novel, previously unrecognized conformational isoform of MIF (designated ‘active MIF’) that is produced in diseases and cannot be detected in healthy subjects. A set of phage display derived human monoclonal anti-MIF antibodies neutralizing MIF biological activity in vitro and in vivo specifically recognize active MIF. In vitro, these antibodies elicited both, a growth inhibitory effect and a pro-apoptotic response on PC3 and DU145 prostate cancer cells by interfering with ERK1/2 and Akt/PKB signaling pathways and by promoting activation of caspase-3. Furthermore, the antibodies inhibited tumor cell invasion of PC3 cells in a transwell assay in a dose-dependent manner. In vivo, treatment with human antibodies specific for active MIF dose-dependently inhibited the growth of the human prostate cancer cell line PC3 xenografted into MF1 nude mice. New ELISA methods have been established to allow the detection of active MIF as well as non-active MIF in plasma samples. In the plasma of PC3 xenografted nude mice, we observed a reduction of active MIF upon antibody treatment. In addition we were able to prove the occurrence of active MIF in the plasma of prostate cancer patients (median 2445 pg/mL, p &amp;lt; 0.002 versus controls), whereas active MIF was not detectable in plasma from healthy donors. These studies demonstrate that active MIF represents a new target in prostate cancer, as well as a promising marker for disease activity or disease progression. The data further suggest that our fully human anti-MIF antibodies have a good potential for clinical use in oncology. Citation Format: Michael Thiele, Michael Freissmuth, Filza Hussain, Patrice Douillard, Dirk Völkel, Hartmut Ehrlich, Friedrich Scheiflinger, Randolf Kerschbaumer. Human antibodies specific for a novel isoform of the macrophage migration inhibitory factor are potential therapeutics for prostate cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1235. doi:10.1158/1538-7445.AM2013-1235
'Leaky' ryanodine receptors and sudden cardiac death
Authors: D. A. Brown, W. E. Cascio
Journal: Cardiovascular Research (2009)

Sudden cardiac death is a significant cause of mortality in the industrialized world, accounting for as much as 30% of deaths in high-risk populations.1 Despite the high incidence, the cellular mechanisms leading to fatal ventricular arrhythmias are not fully understood, thereby hindering the development of novel therapeutic strategies to mitigate this adverse outcome of myocardial infarction. Repolarization heterogeneities have been implicated as substrates for re-entrant arrhythmia, ultimately leading to ventricular fibrillation (VF).2 At the myocyte level, lability in action potential duration and beat-to-beat fluctuations in calcium (Ca2+) transients (Ca2+ alternans) have been observed in several different models as contributing factors to altered repolarization.3,4 Although the importance of intracellular Ca2+ alternans in the aetiology of ventricular arrhythmia is clear, little is known about which pathways in the cellular Ca2+ cycle are altered in VF-prone hearts.

Belevych et al. 5 provide … 

*Corresponding author. Tel: +1 252 744 0083, fax: +1 252 744 5884. E-mail address : casciow{at}ecu.edu
F-18 Fluorodeoxyglocose Positron Emission Tomography/Computed Tomography in the Diagnosis of Chronic Myopathic Sarcoidosis
Authors: Matthew James Loe, Rathan M. Subramaniam, Sanjay Kalra, Robert D. Tiegs, Brian P. Mullan, James P. Utz
Journal: Clinical Nuclear Medicine (2009)

Muscle involvement is a frequent histopathological feature of sarcoidosis, occurring in 50% to 80% of patients, but it is rarely symptomatic, and often, underreported. Although computed tomography and magnetic resonance imaging findings of muscular sarcoidosis have been described, the fluorodeoxyglucose positron emission tomography imaging characteristics have only recently been reported in a case of localized uptake in the lower extremities. We present a case of diffuse uptake within the most common clinical variant of symptomatic muscular sarcoidosis, chronic myopathy, showing significant uptake of F-18 fluorodeoxyglocose on a positron emission tomography/computed tomography fusion examination.
Scintigraphic Patterns of Veno-occlusive Disease in Liver Transplantation
Authors: Hanna Bernstine, Eytan Mor, Ziv Ben Ari, Alexander Belinki, Ruth Hardoff
Journal: Clinical Nuclear Medicine (2004)

Venous vascular complications in liver transplant recipients are rare. Diagnosis is usually based on clinical criteria and typical findings on liver biopsy. The scintigraphic patterns of posttransplant liver veno-occlusive disease are described, and the value of follow-up studies is suggested. The authors present 2 patients who developed posttransplantation hepatic veno-occlusive disease. The first patient had a severe form of the disease and a fatal outcome. The second patient had a mild to moderate form of this disorder with complete resolution following treatment.
Areawide Planning for Emergency Services
Authors: Robert M. Sigmond
Journal: JAMA (1967)

For areawide health planning to be effective, the distinction between emergency and non-emergency services must be recognized. At the same time, it is important that the significant interrelationships of these services be considered in initial planning. It might appear that areawide planning simply involves estimation of the relative volume of care requiring emergency and non-emergency treatment, with an allocation of resources and a configuration of services reflecting the estimated needs. Unfortunately, such planning is more complex. Current patient volume in emergency facilities already exceeds estimates of the need for "true" emergency care, as defined by physicians, and the volume is rising. Continued adaptation of emergency departments to the increasing demand will result in their gradual conversion into ever larger impersonal health supermarkets—into second-rate health centers, ill-adapted for either emergency services or general ambulatory care. Certain adjustments in the total system of providing health services could lead to a reduction in
False-negative Delayed Imaging in Meckel??s Diverticulum
Authors: IRWIN M. FEUERSTEIN, SURESH K. MUKHERJI, CLIFTON A. LEFTRIDGE, DAVID R. STEWART, HAROLD A. GOLDSTEIN
Journal: Clinical Nuclear Medicine (1985)

Scintigraphic scanning for ectopic gastric mucosa using Tc-99m pertechnetate has become the radiographic imaging method of choice in screening for Meckel's diverticulum. Delayed views have been advocated in scans that are normal or equivocal. A case of surgically proven Meckel's diverticulum is presented which demonstrated disappearance of activity after 3½ hours, suggesting a false-negative result. Other atypical features were delayed initial visualization (40 minutes postinjection despite pentagastrin and glucagon augmentation) and location in the left lower quadrant.
Abstract 5364: ATF3 contributes to the DNA damage response by regulating the histone acetyltransferase Tip60
Authors: Hongmei Cui
Journal: Cancer Research (2014)

Abstract Activating transcription factor 3 (ATF3) is a common stress mediator, and its expression is rapidly induced upon DNA damage. Although we have demonstrated that ATF3 can activate the tumor suppressor p53 and regulate expression of p53 target genes, the consequences of ATF3 induction by DNA damage remain elusive. Tat-interactive protein 60 (Tip60) belongs to the MYST family of histone acetyltransferase, and plays important roles in regulating chromatin remodeling, transcription, and the DNA damage response. While Tip60-mediated p53 acetylation promotes pro-apoptotic gene expression, Tip60 can also catalyze acetylation of ATM resulting in increased ATM kinase activity thereby mobilizing DNA repair machinery. Here we report that ATF3 can directly bind Tip60 and regulates its function in the DNA damage response. ATF3 binds Tip60 via its leucine zipper domain, and can increase Tip60 stability by blocking its ubiquitination. This effect is achieved through ATF3 binding to Tip60 as an ATF3 mutant devoid of Tip60 binding fails to block Tip60 ubiquitination and stabilize Tip60. Consistent with these results, knockdown of ATF3 expression decreases the level of Tip60 protein, but not its mRNA. Interestingly, ATM phosphorylation, a marker for ATM activation, is significantly suppressed in ATF3 knockdown cells. Therefore, we identified that ATF3 as a novel regulator of Tip60 in the DNA damage response. Our results suggest that, consistent with its tumor suppressor role, ATF3 may contribute to the DNA damage response by activating ATM signaling. Citation Format: Hongmei Cui. ATF3 contributes to the DNA damage response by regulating the histone acetyltransferase Tip60. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5364. doi:10.1158/1538-7445.AM2014-5364
THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI
Authors: Chandler A. Stetson
Journal: The Journal of Experimental Medicine (1956)

Suspensions of group A streptococci were subjected to mechanical disruption by shaking with glass beads. The supernatant solutions produced severe delayed inflammatory reactions on intradermal injection into normal rabbits. Intravenous injections caused systemic reactions characterized by fever, leucopenia, and peripheral vasomotor phenomena. These effects were more pronounced in rabbits which had previously been infected with group A streptococci. The local and generalized Shwartzman phenomena were reproduced with these crude streptococcal lysates, and the data suggest that streptococci possess an endotoxin similar to those of Gram-negative bacterial species.
A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.
Authors: N Nagvekar, A M Moody, P Moss, I Roxanis, J Curnow, D Beeson, N Pantic, J Newsom-Davis, A Vincent, N Willcox
Journal: Journal of Clinical Investigation (1998)

Myasthenia gravis (MG) is caused by helper T cell-dependent autoantibodies against the muscle acetylcholine receptor (AChR). Thymic epithelial tumors (thymomas) occur in 10% of MG patients, but their autoimmunizing potential is unclear. They express mRNAs encoding AChR alpha and epsilon subunits, and might aberrantly select or sensitize developing thymocytes or recirculating peripheral T cells against AChR epitopes. Alternatively, there could be defective self-tolerance induction in the abundant maturing thymocytes that they usually generate. For the first time, we have isolated and characterized AChR-specific T cell clones from two MG thymomas. They recognize extracellular epitopes (alpha75-90 and alpha149-158) which are processed very efficiently from muscle AChR. Both clones express CD4 and CD8alpha, and have a Th-0 cytokine profile, producing IL-4 as well as IFN-gamma. They are restricted to HLA-DP14 and DR52a; expression of these minority isotypes was strong on professional antigen-presenting cells in the donors' tumors, although it is generally weak in the periphery. The two clones' T cell receptor beta chains are different, but their alpha chain sequences are very similar. These resemblances, and the striking contrasts with T cells previously cloned from non-thymoma patients, show that thymomas generate and actively induce specific T cells rather than merely failing to tolerize them against self antigens.
LIGATION OF THE BROAD LIGAMENTS FOR UTERINE FIBRO MYOMATA—REPORT OF TWO CASES.
Authors: C. C. FREDERICK
Journal: JAMA (1895)

The various forms of treatment and the varied surgical operations for the removal of fibroid tumors of the uterus has, in the past decade, been one of the most prolific subject of discussion in medical circles and the end is not yet. Abdominal hysterectomy—supravaginal amputation, with or without the clamp, or extirpation through the vagina by morcellement, each have their advocates; while other operators of note advise women with uterine fibroids which are giving no special distress to leave them alone. A certain proportion of uterine myo-fibromas produce symptoms which necessitate some operative procedure for their relief. Often the distress is occasioned by the association of a pus tube or an ovarian abscess, the diseased appendages, not the tumor, being the cause of pain and ill health. Should an operator in such a case do a total extirpation? The operation done must fit the case and its varying conditions. If
RUPTURED SINUS OF VALSALVA ANEURYSM WITH SPONTANEOUS CLOSURE OF PERIMEMBRANOUS VENTRICULAR SEPTAL DEFECT: DIFFICULT DIAGNOSIS AND DISCREPANCIES IN MULTI-MODALITY IMAGING
Authors: Satish Chandraprakasam, Alok Saurav, Nachiket Patel, Gopi Sirineni, Mark Holmberg, Chandra Nair, William Biddle, Claire Hunter
Journal: Journal of the American College of Cardiology (2014)
Facial Stigmata and Their Powerful Effects in Literature and Life
Authors: Amy Thorne
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Cryoglobulinemia and Disease
Authors: EUGENE V. BARNETT
Journal: Annals of Internal Medicine (1970)

Serum globulins that precipitate on cooling and redissolve on warming may occur in a variety of clinically dissimilar disorders. In some cases their presence may be a manifestation of "immune-complex disease." A case of postperfusion syndrome apparently due to cytomegalovirus is presented; cryoglobulins and hemolytic anemia were present as part of the syndrome. This case focuses on the interrelationships of deoxyribonucleic acid (DNA) virus, autoimmunity, immune complexes, cryoglobulins, and glomerulonephritis. Studies of the composition of cryoglobulins from the serum of patients with essential cryoglobulinemia and from the synovial fluid of patients with rheumatoid arthritis, although providing no definitive answers, do relate DNA-like antigens and autoantibodies to cryoglobulins. The detection of cryoglobulins in the serum of patients with acute glomerulonephritis further supports the hypothesis that such proteins are the manifestation of immune-complex disease.
Continuing medical education in the 21st century
Authors: R. F Woollard
Journal: BMJ (2008)

Needs to recapture professionalism in lifelong learning

The relations between large bodies of money and the healing professions have often been ambiguous. Commercial interests have sought to influence the course and content of doctors’ education. On the other hand, foundations established through personal wealth have funded some of the principal reports and reflections that have shaped professional education. For example, the Carnegie Foundation supported Abraham Flexner’s 1910 report on the state of medical education in North America. This changed medical schools dramatically in terms of scientific education and commercial influence. As a result, more than 100 schools based on commercial interests closed in subsequent years. Over the following decades, the medical professional and academic communities established accreditation systems of setting standards and mutual site visits with audit, and later quality improvement. 

The interlinked Committee on the Accreditation of Canadian Medical Schools and Liaison Committee on Medical Education currently accredit approximately 150 undergraduate programmes in North America. These committees have profoundly affected undergraduate and postgraduate education by stimulating effective pedagogy devoted to producing dedicated, ethical, and skilled doctors for the future.

In Canada and the United States, respectively, the Committee on the Accreditation of Continuing Medical Education and the Accreditation Council for Continuing Medical Education attempt to do the same for continuing professional development in an environment more akin to the “wild west” that Abraham Flexner observed and excoriated 100 years ago.

The US based Josiah Macy Foundation recently sponsored a conference exploring the state of continuing education.1 The conference was attended by some of the leading developers of continuing education in the US. The resulting report’s reflections on the questionable scientific basis for the practices and content of much continuing education, emphasis on the welfare of doctors …
Cromolyn in Combined Gastrointestinal Allergy-Reply
Authors: Samuel A. Kocoshis
Journal: JAMA (1980)

<h3>In Reply.—</h3> We appreciate Dr Salberg's comments regarding our article. His concerns are legitimate, but we think that our criteria for patient selection, our type of challenge, and our documentation of positive responses remain valid. We agree that laboratory documentation of GI hypersensitivity reactions is helpful, but there are no simple laboratory tests that infallibly identify food sensitivity in children. While we agree the double-blind challenges advocated by Bock and colleagues (<i>J Allergy Clin Immunol</i>62:327, 1978) may establish some types of allergy, we disagree with Dr Salberg's implication that they have supplanted the criteria of Goldman and colleagues<sup>1</sup>for GI allergy. A cause-and-effect relationship between antigen exposure and clinical response underlies the concept of allergy. Objectivity and reproducibility are essential, but double-blind challenges provide only objectivity. Having independently inspected each patient's stool samples and having classified the consistency, besides asking for parents' assessments, we believe we were objective. Many
Antiarrhythmic effects of ACE inhibitors: a matter of faith or reality?
Authors: M. Pahor, G. Gambassi, P. Carbonin
Journal: Cardiovascular Research (1994)

Journal Article Antiarrhythmic effects of ACE inhibitors: a matter of faith or reality? Get access Marco Pahor, Marco Pahor Istituto di Clinica Medica, Cattedra di Gerontologia, Università Cattolica del Sacro Cuore, L.go A Gemelli 8, 00168 Rome, Italy: M Pahor, G Gambassi, P Carbonin. Correspondence to Professor Carbonin. Search for other works by this author on: Oxford Academic PubMed Google Scholar Giovanni Gambassi, Giovanni Gambassi Istituto di Clinica Medica, Cattedra di Gerontologia, Università Cattolica del Sacro Cuore, L.go A Gemelli 8, 00168 Rome, Italy: M Pahor, G Gambassi, P Carbonin. Correspondence to Professor Carbonin. Search for other works by this author on: Oxford Academic PubMed Google Scholar Pierugo Carbonin Pierugo Carbonin Istituto di Clinica Medica, Cattedra di Gerontologia, Università Cattolica del Sacro Cuore, L.go A Gemelli 8, 00168 Rome, Italy: M Pahor, G Gambassi, P Carbonin. Correspondence to Professor Carbonin. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 2, February 1994, Pages 173–182, https://doi.org/10.1093/cvr/28.2.173 Published: 01 February 1994 Article history Received: 14 May 1993 Accepted: 29 June 1993 Published: 01 February 1994
Spontaneous production of tumor necrosis factor alpha by Kupffer cells of MRL/lpr mice.
Authors: D B Magilavy, J L Rothstein
Journal: The Journal of Experimental Medicine (1988)

We report that freshly isolated, unstimulated Kupffer cells (KC) from MRL/lpr female mice in short-term culture spontaneously produce high levels of TNF-alpha. TNF production was first detected in KC cultures at age 6 wk and increased with the age of the mice. Moreover, the levels of spontaneous TNF production by KC directly correlated with the age of the MRL/lpr mice. Although TNF production by KC could be induced with C. parvum in vivo or LPS in vitro in all nonautoimmune C3H/HeN, BALB/c, DBA/2, C57B16 mice, the only other strain in which spontaneous TNF production by KC was observed was MRL/++ mice greater than 10 mo old.
Reduced Expression of Antimicrobial Palate, Lung and Nasal Epithelial Clone (PLUNC) protein in Polyps from Patients with Chronic Rhinosinusitis is Due to Decreased Number of Glands
Authors: S. Seshadri, M. Rosati, D. Lin, R. Carter, J. Norton, A. Kato, L. Suh, A. Peters, R. Chandra, K. Harris, H. Chu, D. Conley, B. Tan, L. Grammer, R. Kern, R. Schleimer
Journal: Journal of Allergy and Clinical Immunology (2011)
Lymphoscintigraphy Demonstrating Thoracic Duct Injury in an Infant With Hypoplastic Left Heart Syndrome
Authors: RENEE M. MOADEL-SERNICK, GREGORY A. CROOKE, LEONARD M. FREEMAN
Journal: Clinical Nuclear Medicine (2000)

Chylous effusion is an infrequent complication of cardiothoracic surgery and a less frequent complication of central line placement. The authors describe a novel application of lymphoscintigraphy showing thoracic duct injury in an infant after surgery for hypoplastic left heart syndrome.
Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease
Authors: Hae-Ki Min, Ashwani Kapoor, Michael Fuchs, Faridoddin Mirshahi, Huiping Zhou, James Maher, John Kellum, Russell Warnick, Melissa J. Contos, Arun J. Sanyal
Journal: Cell Metabolism (2012)