tbuckley/cabot-search huggingface dataset:
Open Supracondylar Fracture of the Humerus
Authors: Otto E. Aufranc
Journal: JAMA (1969)

<h3>Dr. William H. Simon:</h3> This was the first Children's Hospital admission for this 9 1/2-year-old white female. The patient had fallen from a horse, striking the left elbow, approximately one hour before admission. She had been taken to a neighboring hospital where a sterile dressing had been applied to the open wound at the elbow, and the extremity had been splinted with an inflatable splint. She was given tetanus toxoid and a narcotic and was referred to the Children's Hospital. Medical history included no known allergies and no prior surgery. The immunization program was up to date. By physical examination the ears, nose, and throat were normal. The lungs were clear and the heart was in sinus rhythm at 120 beats per minute. The left arm was encased in an air splint in full elbow extension. There was a 4-cm clean, transverse laceration in the antecubital fossa with the proximal
Relationship Between Environmental Tobacco Smoke Exposure and Carcinogen-Hemoglobin Adduct Levels in Nonsmokers
Authors: S. K. Hammond, J. Coghlin, P. H. Gann, M. Paul, K. Taghizadeh, P. L. Skipper, S. R. Tannenbaum
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Relationship Between Environmental Tobacco Smoke Exposure and Carcinogen-Hemoglobin Adduct Levels in Nonsmokers Get access S. Katharine Hammond, S. Katharine Hammond Department of Family and Community Medicine, University of Massachusetts Medical CenterWorcester, Mass. Correspondence to : S. Katharine Hammond, Ph.D., Department of Family and Community Medicine, University of Massachusetts Medical Center, 55 Lake Ave. N., Worcester, MA 01655. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jacalyn Coghlin, Jacalyn Coghlin Department of Family and Community Medicine, University of Massachusetts Medical CenterWorcester, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter H. Gann, Peter H. Gann Department of Family and Community Medicine, University of Massachusetts Medical CenterWorcester, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar Maureen Paul, Maureen Paul Department of Family and Community Medicine, University of Massachusetts Medical CenterWorcester, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar Koli Taghizadeh, Koli Taghizadeh Department of Chemistry and Division of Toxicology, Massachusetts Institute of TechnologyCambridge, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul L. Skipper, Paul L. Skipper Department of Chemistry and Division of Toxicology, Massachusetts Institute of TechnologyCambridge, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar Steven R. Tannenbaum Steven R. Tannenbaum Department of Chemistry and Division of Toxicology, Massachusetts Institute of TechnologyCambridge, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 6, 17 March 1993, Pages 474–478, https://doi.org/10.1093/jnci/85.6.474 Published: 17 March 1993 Article history Received: 09 September 1992 Revision received: 25 November 1992 Accepted: 02 December 1992 Published: 17 March 1993
Platelet Interaction with Polymerizing Fibrin
Authors: Stefan Niewiarowski, Erwin Rogoeczi, Gwendolyn J. Steward, Andrew F. Senyi, J. Fraser Mustard
Journal: Journal of Clinical Investigation (1972)

Interaction of washed pig, rabbit, or human platelets with fibrinogen was studied during its transition to fibrin using photometric, isotopic, and electron microscopic techniques. Untreated fibrinogen and fully polymerized fibrin had no detectable effect on platelets. Fibrinogen, incubated with low concentrations of reptilase or thrombin, formed intermediate products which readily became associated with platelets and caused their aggregation. Neutralization of the thrombin did not prevent this interaction. In the absence of fibrinogen, reptilase did not affect platelets. The interaction of polymerizing fibrin with platelets was accompanied by small losses of platelet constituents (serotonin, adenine nucleotides, platelet factor 4, and lactic dehydrogenase). This loss did not appear to be the result of the platelet release reaction. Inhibitors of the release reaction or of adenosine diphosphate (ADP)-induced aggregation did not prevent the interaction of platelets with polymerizing fibrin. Apyrase or prostaglandin E(1) (PGE(1)) reduced the extent of platelet aggregation by polymerizing fibrin, but the amount of protein associated with platelets was slightly increased. The interaction of polymerizing fibrin with platelets was completely inhibited by ethylenediaminetetraacetate (EDTA) or ethylene glycol bis (beta-aminoethyl ether) N, N,N',N'-tetraacetic acid (EGTA).Fibers formed in solutions of polymerizing fibrin were larger in the presence than in the absence of washed platelets, suggesting that platelets affect fibrin polymerization. The adherence of platelets to polymerizing fibrin may be responsible for the establishment of links between platelets and fibrin in hemostatic plugs and thrombi.
Effects of operation on left atrial size and the occurence of atrial fibrillation in patients with hypertrophic subaortic stenosis.
Authors: D C Watson, W L Henry, S E Epstein, A G Morrow
Journal: Circulation (1977)

The relation between left atrial size and atrial fibrillation was examined in 37 patients who had left ventriculomyotomy and myectomy at the National Heart and Lung Institute. Atrial fibrillation was present in 11 of 27 (41%) patients with an echocardiographically measured left atrial dimension greater than 45 mm. No patient with a left atrial dimension less than 45 mm had atrial fibrillation pre or postoperatively. Eleven of 13 patients less than 40 years of age with an abnormal preoperative left atrial dimension had a 10% or greater reduction in left atrial dimension postoperatively. A group of 21 patients 40 years of age or older had an abnormal left atrial dimension preoperatively, and no significant change postoperatively. These results indicate that left ventriculomyotomy and myectomy can produce a significant decrease in left atrial size in younger patients with idiopathic hypertrophic subaortic stenosis. It is hoped that the decrease in atrial size may reduce the risk of atrial fibrillation in these patients.
Cardiac MR perfusion image processing techniques: A survey
Authors: Vikas Gupta, Hortense A. Kirişli, Emile A. Hendriks, Rob J. van der Geest, Martijn van de Giessen, Wiro Niessen, Johan H.C. Reiber, Boudewijn P.F. Lelieveldt
Journal: Medical Image Analysis (2012)
High levels of 8-hydroxy-2′-deoxyguanosine appear in normal human epidermis after a single dose of ultraviolet radiation
Authors: N.U. AHMED, M. UEDA, O. NIKAIDO, T. OSAWA, M. ICHIHASHI
Journal: British Journal of Dermatology (1999)

Journal Article High levels of 8‐hydroxy‐2′‐deoxyguanosine appear in normal human epidermis after a single dose of ultraviolet radiation Get access N.U. AHMED, N.U. AHMED Department of Dermatology, Kobe University School of Medicine, 7‐5‐1, Kusunoki cho, Chuo‐ku, Kobe 650, Japan, Search for other works by this author on: Oxford Academic Google Scholar M. UEDA, M. UEDA Department of Dermatology, Kobe University School of Medicine, 7‐5‐1, Kusunoki cho, Chuo‐ku, Kobe 650, Japan, Masato Ueda E‐mail: mueda@ med.kobe‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar O. NIKAIDO, O. NIKAIDO Division of Radiation Biology, Faculty of Pharmaceutical Science, Kanazawa University, Kanazawa, Japan, Search for other works by this author on: Oxford Academic Google Scholar T. OSAWA, T. OSAWA Nagoya University School of Agriculture, Nagoya, Japan Search for other works by this author on: Oxford Academic Google Scholar M. ICHIHASHI M. ICHIHASHI Department of Dermatology, Kobe University School of Medicine, 7‐5‐1, Kusunoki cho, Chuo‐ku, Kobe 650, Japan, Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 140, Issue 2, 1 February 1999, Pages 226–231, https://doi.org/10.1111/j.1365-2133.1999.02653.x Published: 01 February 1999
Healthspeak for All Seasons
Authors: George Dunea
Journal: JAMA (1974)

THE Comprehensive Regional Ultimate Mediplan (CRUM) is a multiagency modular system that coordinates all provider programs aimed at special consumer targets. CRUM achieves its distinctive though complementary goals through a multifaceted system of facilities linked together by a computer network. Its activities are described in its weekly newsletter, the<i>Global Planner</i>, which is written in "Healthspeak," a language that abounds in clichés specially devised to satisfy the linguistic needs of Healthplanners. CRUM programs include strong educational components—patient education, doctor education, and nurse education—with regular symposia that feature prominent out-of-town speakers, and two-day workshops with separate sessions for doctors, nurses, and technicians. High-visibility CRUM buses—painted red and with distinctive signs in large letters—will bring doctors to patients, patients to doctors, and screen for early signs of disease. Outreach facilities will be set up in a grocery, a storefront, a factory, a church, or a tent, with teams of provider paramedical healthworker
Distal biliary stricture as a complication of sclerosant injection for bleeding duodenal ulcer.
Authors: W Luman, N Hudson, C P Choudari, M A Eastwood, K R Palmer
Journal: Gut (1994)

A patient undergoing repeated endoscopic injection therapy for important bleeding from a duodenal ulcer developed intestinal perforation followed by extrahepatic obstructive jaundice resulting from benign biliary stricture. It is proposed that these complications were a consequence of the use of ethanolamine oleate as part of the injection regimen and caution against the use of this material is needed, particularly as current clinical trials suggest that sclerosants offer no advantage over injection therapy with dilute adrenaline alone.
Evaluation of the Prognostic Significance of Perirenal Fat Invasion and Tumor Size in Patients with pT1–pT3a Localized Renal Cell Carcinoma in a Comprehensive Multicenter Study of the CORONA project. Can We Improve Prognostic Discrimination for Patients with Stage pT3a tumors?
Authors: Sabine D. Brookman-May, Matthias May, Ingmar Wolff, Richard Zigeuner, Georg C. Hutterer, Luca Cindolo, Luigi Schips, Ottavio De Cobelli, Bernardo Rocco, Cosimo De Nunzio, Andrea Tubaro, Ioman Coman, Michael Truss, Orietta Dalpiaz, Bogdan Feciche, Robert S. Figenshau, Kerry Madison, Manuel Sánchez-Chapado, Maria del Carmen Santiago Martin, Luigi Salzano, Giuseppe Lotrecchiano, Stefan Zastrow, Manfred Wirth, Petros Sountoulides, Shahrokh Shariat, Raphaela Waidelich, Christian Stief, Sven Gunia
Journal: European Urology (2015)
The Alveolar-Capillary Membrane and Pulmonary Edema
Authors: Jan P. Szidon, Giuseppe G. Pietra, Alfred P. Fishman
Journal: New England Journal of Medicine (1972)

CONVENTIONAL teaching, based on light microscopy, has dealt with the physiopathology of pulmonary edema in terms of a simple barrier separating pulmonary capillaries from the alveolar spaces. According to this simplistic view, pulmonary edema represents the extravasation of a filtrate of plasma directly from pulmonary capillaries into alveoli as the result of one of two alternative mechanisms: an imbalance of forces operating across a normal alveolar-capillary barrier so that reabsorptive forces cannot cope with the high transcapillary filtration rates; or, despite normal transcapillary forces, excessive passage of plasma filtrate out of the capillary because of a breakdown of the barrier. . . .
Effect of Folic Acid and B Vitamins on Cardiovascular Disease in Women
Authors: Ainur Akilzhanova
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NAD(P)H oxidase–dependent platelet superoxide anion release increases platelet recruitment
Authors: Florian Krötz, Hae Young Sohn, Torsten Gloe, Stefan Zahler, Tobias Riexinger, Thomas M. Schiele, Bernhard F. Becker, Karl Theisen, Volker Klauss, Ulrich Pohl
Journal: Blood (2002)
Book Review Prostate Cancer: Biology, Genetics, and the New Therapeutics (Contemporary Cancer Research.) Edited by Leland W.K. Chung, William B. Isaacs, and Jonathan W. Simons. 531 pp. Totowa, N.J., Humana Press, 2001. $145. 0-89603-868-8
Authors: Aria F. Olumi
Journal: New England Journal of Medicine (2002)
Fingerprint changes in dermatitis herpetiformis.
Authors: J Verbov, P J Kumar, R Marks
Journal: BMJ (1971)

nodes.This may well link up with the work done by Hawley et al.2 and Paile5 suggesting that some patients may do better because their cellular immune mechanisms are putting up resistance to the primary, and they may do well even if some metastases have reached a few local nodes.This is an important problem, because the surgeon at laparotomy who finds some palpable nodes near a resectable gastric tumour may well decide against radical local dis- section on the basis of an apparently hopeless prognosis ("glandular metastases").My study showed that where surgeons reported "malignant glands present," the histological findings in no less than 1: 3 patients were of OX or LTH status (and therefore a better prognosis).In other words, there are two reasons to continue with radical lymphatic surgery, even with palpable nodes.Firstly, they may be benign, and secondly, they may represent the minimal invasion and quite good prognosis situation.For those who can stand awful doggerel this may be sum- marized: "All that bulge are not maligne, Even be some so, do not pyne."May I also point out the fact that early diagnosis of gastric cancer, and greatly im- proved results in treatment, have been taken a stage further by the use of gastric cytology, with or without fibrescope collecting methodS.6 7-I am, etc.,
Brazil investigates drug's possible link with birth defects
Authors: J Rocha
Journal: BMJ (1994)

In Brazil, many women are using the synthetic prostaglandin misoprostol to induce abortion. Since abortion is illegal in Brazil, they take misoprostol without any medical supervision. It was introduced in Brazil in 1986 as a treatment for gastric ulcers. Its brand name is Cytotec. The prescription drug is widely available on the black market, where the price for 4 200-mg tablets begins at US$100. Use of the drug with failure to abort may be linked to birth defects. A geneticist and a neuropediatrician at the Children's Institute of the Sao Paulo Hospital das Clinicas are studying 9 children with congenital or neurological abnormalities. Physicians in other parts of Brazil are following another 30 children with the same circumstances. A physician in Porto Alegre is following 40 women who took misoprostol but did not abort. As of mid 1994, she had found 3 cases of congenital abnormalities. The Brazilian Society for Clinical Genetics is overseeing an epidemiologic study in 10 major maternity hospitals where researchers will examine all neonates and ask all mothers about the possible use of misoprostol. Staff at the genetics outpatient clinics of 6 leading hospitals are about to conduct a related study among mothers. Both of these studies run the risk of low reporting, since mothers may be disinclined to admit to criminal use of misoprostol. Almost 50% of all women who want pregnancy termination in Brazil use misoprostol. The abortion fails in about 33% of these cases. The evidence suggests an 8-10% risk of abnormalities among women who use misoprostol and experience abortion failure. Ministry of Health sources unofficially appreciate that misoprostol use is reducing the number of women hospitalized with infections caused by abortion attempts with sharp instruments, which in turn has reduced maternal mortality.
How accurately can direct and indirect inguinal hernias be distinguished?
Authors: D N Ralphs, A J Brain, D J Grundy, M Hobsley
Journal: BMJ (1980)

An inguinal hernia was clinically diagnosed as direct or indirect by paired surgeons of 134 occasions. When compared with the findings at operation the hernia was correctly diagnosed in 60 of 78 observations when it was indirect and in 33 of 56 when it was direct. The level of accuracy does not warrant continuing the practice of attempting to distinguish one type of inguinal hernia from another.
Effects of Growth Hormone Administration on Inflammatory and Other Cardiovascular Risk Markers in Men with Growth Hormone Deficiency
Authors: Gemma Sesmilo
Journal: Annals of Internal Medicine (2000)

Background: Growth hormone–deficient adults have increased cardiovascular mortality. Growth hormone replacement may affect cardiovascular risk. Inflammation plays an important role in atherosclerosis, and inflammatory markers are predictive of cardiovascular events. Objective: To investigate the effect of growth hormone replacement on inflammatory and other cardiovascular risk factors. Design: Randomized, single-blind, placebo-controlled trial. Patients: 40 men with adult-onset growth hormone deficiency. Intervention: Growth hormone or placebo given for 18 months at a dose adjusted for normal serum insulin-like growth factor I level. Measurements: Anthropometric, hemoglobin A1c, and central fat values were assessed every 6 months. Levels of glucose, insulin, insulin-like growth factor I, and lipids were measured at 1, 3, 6, 12, and 18 months. C-reactive protein, serum amyloid polypeptide A, interleukin-6, and lipoprotein(a) levels were determined at baseline and 6 and 18 months. Results: C-reactive protein and interleukin-6 levels decreased in growth hormone recipients compared with placebo recipients (differences between groups, −1.9 ± 0.6 mg/L [P = 0.0027] and −1.3 ± 0.5 ng/L [P = 0.013], respectively). Changes in serum amyloid polypeptide A levels between groups did not reach statistical significance (difference between groups, −2.4 ± 1.2 mg/L; P = 0.056). Serum cholesterol levels, low-density lipoprotein cholesterol levels, and ratios of total cholesterol to high-density lipoprotein cholesterol decreased in growth hormone recipients in the first 3 months compared with placebo recipients (differences between groups, −0.86 ± 0.17 mmol/L [−33.2 ± 6.6 mg/dL] [P < 0.001], −0.63 ± 0.20 mmol/L [−24.5 ± 5.9 mg/dL] [P < 0.001], and −0.56 ± 0.26 [P = 0.040], respectively), but the decrease was not maintained from month 6 to month 18. Lipoprotein(a) levels increased (difference between groups, 22.0 ± 8.0 mg/L; P = 0.0096). Short-term increases occurred in glucose levels, insulin levels, and insulin-to-glucose ratios (differences between groups, 0.54 ± 0.16 mmol/L [9.6 ± 2.8 mg/dL] [P = 0.0018], 37.9 ± 9.6 pmol/L [P < 0.001], and 6.0 ± 1.8 [P = 0.0025], respectively), but only the increase in glucose level was maintained over the long term (difference between groups, 0.56 ± 0.17 mmol/L [10.0 ± 3.1 mg/dL]; P = 0.0026). Hemoglobin A1c values did not change. Truncal fat–to–total fat ratios decreased (difference between groups, −0.018 ± 0.007; P = 0.0087). Conclusions: Long-term growth hormone replacement in men reduces levels of inflammatory cardiovascular risk markers, decreases central fat, and increases lipoprotein(a) and glucose levels without affecting lipid levels.
Effect of evidence based risk information on "informed choice" in colorectal cancer screening: randomised controlled trial
Authors: A. Steckelberg, C. Hulfenhaus, B. Haastert, I. Muhlhauser
Journal: BMJ (2011)

<b>Objective</b> To compare the effect of evidence based information on risk with that of standard information on informed choice in screening for colorectal cancer. <b>Design</b> Randomised controlled trial with 6 months’ follow-up. <b>Setting</b> German statutory health insurance scheme. <b>Participants</b> 1577 insured people who were members of the target group for colorectal cancer screening (age 50-75, no history of colorectal cancer). <b>Interventions</b> Brochure with evidence based risk information on colorectal cancer screening and two optional interactive internet modules on risk and diagnostic tests; official information leaflet of the German colorectal cancer screening programme (control). <b>Main outcome measure</b> The primary end point was “informed choice,” comprising “knowledge,” “attitude,” and “combination of actual and planned uptake.” Secondary outcomes were “knowledge” and “combination of actual and planned uptake.” Knowledge and attitude were assessed after 6 weeks and combination of actual and planned uptake of screening after 6 months. <b>Results</b> The response rate for return of both questionnaires was 92.4% (n=1457). 345/785 (44.0%) participants in the intervention group made an informed choice, compared with 101/792 (12.8%) in the control group (difference 31.2%, 99% confidence interval 25.7% to 36.7%; P&lt;0.001). More intervention group participants had “good knowledge” (59.6% (n=468) <i>v</i> 16.2% (128); difference 43.5%, 37.8% to 49.1%; P&lt;0.001). A “positive attitude” towards colorectal screening prevailed in both groups but was significantly lower in the intervention group (93.4% (733) <i>v</i> 96.5% (764); difference −3.1%, −5.9% to −0.3%; P&lt;0.01). The intervention had no effect on the combination of actual and planned uptake (72.4% (568) <i>v</i> 72.9% (577); P=0.87). <b>Conclusions</b> Evidence based risk information on colorectal cancer screening increased informed choices and improved knowledge, with little change in attitudes. The intervention did not affect the combination of actual and planned uptake of screening. <b>Trial registration</b> Current Controlled Trials ISRCTN47105521.
Impact of Glycemic Control on Survival of Diabetic Patients on Chronic Regular Hemodialysis: A 7-Year Observational Study
Authors: Miroslaw Śnit, Marek Dwornicki, Ewa Z⋅ukowska-szczechowska, Władysław Grzeszczak
Journal: Diabetes Care (2006)

In their Diabetes Care article, Oomichi et al. (1) stated that poor glycemic control is an independent predictor of poor prognosis of survival in patients on chronic regular dialysis. In the dialysis center of the Clinic of Internal Medicine, Diabetology and Nephrology in Zabrze, we have undertaken regular dialysis of ∼200 patients. We have recently published our experiences in regards to renal replacement therapy, especially concerning diabetic patients (2,3), but we have never analyzed the relationship between …