tbuckley/cabot-search huggingface dataset:
Quotations on the Wall
Authors: J. Willis Hurst
Journal: Annals of Internal Medicine (1999)

Medical Writings5 October 1999Quotations on the WallJ. Willis Hurst, MDJ. Willis Hurst, MDEmory University School of Medicine; Atlanta, GA 30322 (Hurst)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-7-199910050-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail My sixth-grade teacher, Miss Mary, loved quotations and encouraged me to collect and learn from them. As I grew older, I discovered a disturbing divergence of opinion among great thinkers about the value of quotations.Winston Churchill wrote the following sentences about quotations. Although he favored reading them, his first sentence is a bit disconcerting. “It is a good thing for an uneducated man to read books of quotations. Bartlett's Familiar Quotations is an admirable work, and I studied it intently. The quotations when engraved upon the memory give you good thoughts. They also make you anxious to read the ...References1. Churchill W. My Early Life: A Roving Commission. New York: Scribner; 1930:9. Google Scholar2. Cioran EM. Anathemas and Admirations. Howard R, tr. New York: Arcade; 1988:9. Google Scholar3. Emerson RW. Quotation and originality. In: Letters and Social Aims. 1876. Google Scholar Author, Article, and Disclosure InformationAuthors: J. Willis Hurst, MDAffiliations: Emory University School of Medicine; Atlanta, GA 30322 (Hurst)Note: Many of the quotations used in this essay can be found in Bartlett's Familiar Quotations, published by Little, Brown and Company in 1980, and Quotationary, written by Leonard Roy Frank and published by Random House in 1999. The exact sources of the quotations are listed in the references or under each quotation.Corresponding Author: J. Willis Hurst, MD, 1462 Clifton Road, NE, Suite 301, Atlanta, GA 30322. For reprint orders in quantities exceeding 100, please contact the Reprints Coordinator; phone, 215-351-2657; e-mail, reprints@mail.acponline.org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOn the Death of House Officers Faith Fitzgerald and T. Jock Murray Quotations on the Wall Harish Jasti Metrics Cited byUse of a Pre-Assessment Tool to Start a Meaningful Dialogue: New Paradigms in Library InstructionTranslating outcomes research into fiscal responsibility and knowledge management in health careQuotations on the WallHarish Jasti, MD 5 October 1999Volume 131, Issue 7 Page: 551-554 Keywords Electrocardiography Forecasting Heart Memory Running Shock Sleep Smell Taste Touch ePublished: 15 August 2000 Issue Published: 5 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hyperaemic hypoxia in venous ulceration
Authors: H. Partsch
Journal: British Journal of Dermatology (1984)

Journal Article Hyperaemic hypoxia in venous ulceration Get access H. Partsch, Dr H. Partsch, Dr Vascular Service, Hanusch‐Hospital, A‐1140 Vienna, Austria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 110, Issue 2, 1 February 1984, Pages 249–251, https://doi.org/10.1111/j.1365-2133.1984.tb07481.x Published: 01 February 1984
Validity of smokers' information about present and past cigarette brands--implications for studies of the effects of falling tar yields of cigarettes on health.
Authors: H Peach, D Shah, R W Morris
Journal: Thorax (1986)

Four hundred and twenty nine current smokers and ex-smokers who had provided details 12 years previously completed a self administered questionnaire about their present and past smoking habits, and two weeks later current smokers supplied an empty cigarette packet. The tar group and brand name of the current cigarette given on the questionnaire were compared with details on the packet, and the brand alleged to have been smoked 12 years ago was compared with that actually recorded at that time. Only 55% of "low middle" tar cigarettes as indicated by returned packets had been correctly identified in the questionnaire. The brand name was the same in the questionnaire and on the packet in 74% of cases. The recalled brand was confirmed by past records in only 49% of cases. It is concluded that current smokers should be asked to return an empty packet or packets of the cigarette brand or brands usually smoked with a self administered questionnaire and that follow up studies of populations for which brands of cigarette smoked were previously recorded might be more valid than studies relying on recall.
Encephalopathy Following Jejunoileostomy
Authors: Daniel B. Carr
Journal: JAMA (1982)

<h3>To the Editor.—</h3> In a recent article, Ayub et al described seven patients with intermittent encephalopathy after jejunoileostomy performed for morbid obesity (1981;246:970). Their patients complained of episodes of confusion, lethargy, and ataxia lasting a few hours to several days. Electroencephalography performed in two symptomatic patients demonstrated diffuse slowing that returned to normal after clinical recovery. A hyperchloremic metabolic acidosis was present in two patients, but it was not clear whether other patients were observed during their spells. <h3>Report of a Case.—</h3> We recently encountered a 36-year-old man who had a jejunoileostomy five years earlier. He complained of "spells" for one year, each consisting of somnolence, ataxia, irritability, and craving for water and food lasting up to several days.<sup>1</sup>Detailed neuroendocrine evaluation was normal. Electroencephalograms during two attacks demonstrated diffuse, high-voltage, slow-wave activity but were normal between attacks. A self-limited metabolic acidosis was observed to coincide with the onset
Positive Inotropic Effects by Uridine Triphosphate (UTP) and Uridine Diphosphate (UDP) via P2Y <sub>2</sub> and P2Y <sub>6</sub> Receptors on Cardiomyocytes and Release of UTP in Man During Myocardial Infarction
Authors: Anna-Karin Wihlborg, Johanna Balogh, Lingwei Wang, Catharina Borna, Ying Dou, Bhalchandra V. Joshi, Eduardo Lazarowski, Kenneth A. Jacobson, Anders Arner, David Erlinge
Journal: Circulation Research (2006)

The aim of this study was to examine a possible role for extracellular pyrimidines as inotropic factors for the heart. First, nucleotide plasma levels were measured to evaluate whether UTP is released in patients with coronary heart disease. Then, inotropic effects of pyrimidines were examined in isolated mouse cardiomyocytes. Finally, expression of pyrimidine-selective receptors (a subgroup of the P2 receptors) was studied in human and mouse heart, using real time polymerase chain reaction, Western blot, and immunohistochemistry. Venous plasma levels of UTP were increased (57%) in patients with myocardial infarction. In electrically stimulated cardiomyocytes the stable P2Y(2/4) agonist UTPgammaS increased contraction by 52%, similar to beta1-adrenergic stimulation with isoproterenol (65%). The P2Y6-agonist UDPbetaS also increased cardiomyocyte contraction (35%), an effect abolished by the P2Y6-blocker MRS2578. The phospholipase C inhibitor U73122 inhibited both the UDPbetaS and the UTPgammaS-induced inotropic effect, indicating an IP3-mediated effect via P2Y6 receptors. The P2Y14 agonist UDP-glucose was without effect. Quantification of mRNA with real time polymerase chain reaction revealed P2Y2 as the most abundant pyrimidine receptor expressed in cardiomyocytes from man. Presence of P2Y6 receptor mRNA was detected in both species and confirmed at protein level with Western blot and immunohistochemistry in man. In conclusion, UTP levels are increased in humans during myocardial infarction, giving the first evidence for UTP release in man. UTP is a cardiac inotropic factor most likely by activation of P2Y2 receptors in man. For the first time we demonstrate inotropic effects of UDP, mediated by P2Y6 receptors via an IP3-dependent pathway. Thus, the extracellular pyrimidines (UTP and UDP) could be important inotropic factors involved in the development of cardiac disease.
360 ASSOCIATION STUDY OF IFNAR2 AND IL10RB GENES WITH THE SUSCEPTIBILITY AND INTERFERON RESPONSE IN HBV INFECTION
Authors: Q.-M. Gong, X.-F. Kong, Z.-T. Yang, J. Xu, L. Wang, X.-H. Li, D.-H. Zhang, J.-H. Jiang, X.-X. Zhang
Journal: Journal of Hepatology (2009)
Developing a marker of exposure to xenoestrogen mixtures in human serum.
Authors: A M Soto, M F Fernandez, M F Luizzi, A S Oles Karasko, C Sonnenschein
Journal: Environmental Health Perspectives (1997)

It has been hypothesized that environmental estrogens may play a role in the increasing incidence of breast cancer, testicular cancer, and other problems of the reproductive system. While a single causal agent can be identified in cases in which humans have had occupational exposures, wildlife showing signs of reproductive damage have usually been exposed to a combination of endocrine disruptors that may act cumulatively. The development of appropriate biomarkers of cumulative exposure, and their measurement at developmental points where exposure is critical, are required to test the environmental estrogen hypothesis. Measuring levels of each of the xenoestrogens in blood is a better approximation of real exposure at the target organ level than inferring cumulative exposure by estimating from mass balance of dietary levels. However, the cumulative estrogenicity of mixtures cannot be directly concluded from individual xenoestrogen plasma levels. Two approaches may be used to assess total load: a) the development of methods to study mixtures of these xenoestrogens, to quantify their cumulative effects, and to begin to understand their interactions (i.e., additivity, synergy, antagonism, or independent action), so that plasma concentrations may be translated into units of activity such as "estradiol equivalents"; and b) the development of methods to separate xenoestrogens from ovarian estrogens in blood and to directly measure the estrogenic activity of the xenoestrogen extract using a bioassay. The cumulative activity may be used as a marker of exposure to xenoestrogens. This article reports the development of a method to extract and separate xenoestrogens from ovarian estrogens using human serum as a source, followed by using a bioassay for determination of the cumulative xenoestrogen load as "estradiol equivalents."
Choice and responsiveness for older people in the "patient centred" NHS
Authors: D. R Rowland
Journal: BMJ (2004)

New community care regulations mean that older people may not be able to choose where they are treated 

According to the health secretary, John Reid, a patient centred NHS driven by the principles of choice and competition will improve equitable access to health care in particular for the poor and disadvantaged. The patient, and not the provider, will be king while NHS provision will still be provided on the basis of equal treatment for equal need. But it is difficult to reconcile this vision of choice and equity with the Community Care (Delayed Discharge) Act, which comes into force in January 2004.

From January 2004 local authorities will be fined by the NHS for failing to arrange social care services for patients who are no longer appropriately situated in an acute hospital bed. Under the provisions of the Community Care Act social service departments will have a minimum of two days to assess the needs of a patient and arrange a suitable package of care—whether this be at home or in other forms of accommodation—or face a fine of £100 ($177; €142) for every day the patient remains in hospital. If on Monday at 2 pm an acute trust issues a notification to local …
The point prevalence of an abnormal ankle-brachial index in antiphospholipid antibody negative patients with livedo reticularis: a controlled study: Table 1
Authors: S Sangle, C Christodoulou, S Paul, G R V Hughes, D P D’Cruz
Journal: Annals of the Rheumatic Diseases (2008)

Livedo reticularis (livedo) is characterised by reticular cyanotic cutaneous discolouration surrounding a pale central area. Physiological livedo, also known as cutis marmorata, is common in young women on exposure to cold. Pathological livedo is characterised by a fixed broken pattern, which is occasionally associated with ulceration. Livedo is frequently seen in antiphospholipid (Hughes) syndrome (APS), and appears to be associated with a worse prognosis.1 A number of patients have recently been described who have many features of APS including thrombosis, livedo and pregnancy morbidity in the absence of antiphospholipid antibodies (aPL).2 Our aim was to assess the prevalence and …
Smoking resumption after lung transplantation: a sobering truth
Authors: R. Vos, K. De Vusser, V. Schaevers, A. Schoonis, V. Lemaigre, F. Dobbels, K. Desmet, B. M. Vanaudenaerde, D. E. Van Raemdonck, L. J. Dupont, G. M. Verleden
Journal: European Respiratory Journal (2010)

<h3>Abstract</h3> Nervous system development and plasticity involves changes in cellular morphology, making morphological analysis a valuable exercise in the study of nervous system development, function and disease. Morphological analysis is a time-consuming exercise requiring meticulous manual tracing of cellular contours and extensions. We have developed a software tool, called SMorph, to rapidly analyse the morphology of cells of the nervous system. SMorph performs completely automated Sholl analysis. It extracts 23 morphometric features based on cell images and Sholl analysis parameters, followed by Principal Component Analysis. SMorph is tested on neurons, astrocytes and microglia and reveals subtle changes in cell morphology. Using SMorph, we found that chronic 21-day treatment with antidepressant desipramine results in a significant structural remodeling in hippocampal astrocytes. Given the proposed involvement of astroglial structural changes and atrophy in major depression in humans, our results reveal a novel kind of structural plasticity induced by chronic antidepressant administration.
Dendritic cells in intestinal homeostasis and disease
Authors: Maria Rescigno, Antonio Di Sabatino
Journal: Journal of Clinical Investigation (2009)

DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.
Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family.
Authors: M M Newkirk, H Gram, G F Heinrich, L Ostberg, J D Capra, R L Wasserman
Journal: Journal of Clinical Investigation (1988)

The complete amino acid and nucleotide sequences of the variable regions of the heavy and light polypeptide chains of a human neutralizing IgGl anti-cytomegalovirus (CMV) antibody reveal a striking homology to IgM rheumatoid factors (RFs) of the Wa idiotypic family. The anti-CMV antibody and Wa RFs have in common VKIIIb, JKl, and VHIa gene segments but use different DH and JH gene segments. The anti-CMV antibody does not have RF activity and does not express the Wa idiotype. The Wa RFs do not have anti-CMV activity. A subset of Wa RFs, however, and the anti-CMV antibody do share several idiotypes on the VHIa and VKIIIb polypeptides. Since there are major differences in the antigen binding characteristics and some of the other expressed idiotypes, these data suggest that the D and J region amino acids are crucial to such specificities. Although the use of such highly homologous gene segments in different immune responses is well-documented in murine systems, these data represent the first such example in the human.
Valeur diagnostique de l'analyse du liquide de ponction des lésions kystiques pancréatiques prélevé sous échoendoscopie: étude prospective chez 114 patients
Authors: P Andrau, B Bournet, L Nogueira, J Moreau, J Escourrou, L Buscail
Journal: Endoscopy (2008)

Introduction: Les progrès de l'imagerie permettent la détection de lésions kystiques pancréatiques dont le caractère uniloculaire peut faire évoquer une lésion mucineuse. La décision opératoire est parfois difficile à prendre et l'analyse du liquide intrakystique prélevé sous échoendoscopie peut aider à cette décision. Le but de cette étude était: chez des patients porteurs de kystes pancréatiques uniloculaires, évaluer et valider dans notre centre de façon prospective la valeur de l'analyse du liquide de ponction sous échoendoscopique.
A Case of Loose Body in the Kneejoint due to Detachment of Articular Cartilage, with Remarks on the Frequency of Such an Occurrence
Authors: F. F. Burghard
Journal: BMJ (1892)

1YBL= Uo n& 1017 attack; in one, at the first remission.While the tem- peratures were 1000 and above the pulse and respiration rates were recorded, and these (averaged) stand in the ratio of 85.5 to 25 to an average temperature of 1010, the average ages of the subjects being somewhat over middle age.A s regards quality, the pulse was often full and strong at the beginning but soon degenerated, and dicrotism was of frequent occur- rence.In cardiac patients intermittency and irregularity were either induced or markedly aggravated.There were no examples of rash.Fatal Caases.-Fourcases ended fatally, the chief points of which are tabulated below:- S ~~Average.Mental Disease. BonoodilyDuraa) j , e Condition.Ilnes.0 F. 133 Melancholia Amenorrhcea; 4 days 103.50
Review says oseltamivir and zanamivir should be kept for epidemics of flu
Authors: Susan Mayor
Journal: BMJ (2006)

The neuraminidase inhibitors oseltamivir (Tamiflu) and zanamivir (Relenza) may be effective in serious epidemic or pandemic influenza but must be used together with infection control procedures, says a Cochrane review published last week. The review said that these drugs should not be used for seasonal flu but should be kept for serious epidemics and that other antivirals should not be used at all for flu.

The review, which was published online ahead of print publication on 19 January in the Lancet (www.thelancet.com, doi: 10.1016/S0140-6736(06)67970-1), analysed data from randomised controlled trials of both classes of antivirals currently used to prevent or treat flu: the M2 ion channel inhibitors, amantadine and rimantadine, and two of the newer neuraminidase inhibitors, zanamivir and …
Role of Functional Block Extension in Lesion-Related Atrial Flutter
Authors: Yasushi Tomita, Kunihiro Matsuo, Jayakumar Sahadevan, Celeen M. Khrestian, Albert L. Waldo
Journal: Circulation (2001)

Background —A line of block in the right atrium (RA) between the venae cavae is necessary to obtain classic atrial flutter (AFL). We tested the hypothesis that the location of that line of block would determine whether the AFL reentrant circuit would be due to single-loop reentry or figure-of-8 reentry. Methods and Results —Simultaneous mapping from 392 sites (both atria and the atrial septum) was performed in 13 normal dogs before and after creating a linear lesion on the RA free wall. The lesion was 1 to 1.5 cm anterior and parallel to the crista terminalis (7 dogs) or posterior and close to the crista terminalis region (6 dogs). Sustained AFL (&gt;2 minutes) was then induced. In 4 dogs with an anterior lesion, the AFL reentrant circuit traveled around the lesion (lesion reentry). In 9 dogs (3 with anterior lesions and 6 with posterior lesions), the AFL reentrant circuit included the anterior RA free wall, the atrial septum, and Bachmann’s bundle (single-loop reentry). In these 9 dogs, the fixed line of block was extended to the superior and/or inferior vena cava by a functional line of block, thereby preventing lesion reentry. No figure-of-8 reentry was induced. Conclusions —In this model, the location of a fixed line of block and its functional extension determine the type of AFL reentry. These data provide an explanation for the chronic AFL that occurs in some patients after surgical repair of congenital heart lesions.
The Reason I Am
Authors: Simona Gurzu
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
MUSCULOSKELETAL TESTING OF ORIENTEERS DURING PRE-PARTICIPATION EVALUATION AND ASSOCIATIONS WITH LIMB DOMINANCE AND INJURY HISTORY
Authors: L Linton, C Laura, S Tessa
Journal: British Journal of Sports Medicine (2014)

Background Limb dominance has often been associated with injury, but there is very little evidence for this in the literature for elite runners. Objective To test for differences in strength, flexibility and function between dominant and non-dominant sides of elite orienteers, to determine a relationship with injury history, and establish a correlation between test results. Design A standardized PPE of 45 tests customized to the specifics of middle distance runners was used to assess all variables. Setting Edinburgh University, Fitness Assessment Sports Injury Clinic. Participants All 17 National Level Orienteers participating in a High Performance program at Edinburgh University during 2011–12 were selected. All were well matched for age, training and competitive level. Interventions Testing took place pre-season. Subjects were assessed by their regular physiotherapist for limb dominance and injury history. The main researcher was blinded to this information and undertook the PPE testing. Main outcome measurements Muscle power was tested with HHD, flexibility using a goniometer, knee valgus angles using video analysis, core strength using pressure biofeedback. Results Non-dominant legs had significantly (P&lt;.01) greater knee valgus angle measured during single knee bend. Subjects had significantly increased thoracic spine rotation on the side they held their map whilst running. There was no relationship between retrospective injury history and limb dominance. In both dominant and non-dominant sides there were equally strong correlations (P&lt;.01) with functional tests, lower limb, hip, abdominal, and glut strength, and quadriceps and hip flexor flexibility. Conclusions Few tests showed a relationship with dominant or non-dominant legs. Data collected on specific tests showed associations that were similar on both sides indicating the bilateral nature of running but also the relationship between trunk muscles and the lower limb. Future study in this area should focus on whether interventions addressing these areas show improvement in function and reduction of injuries.