Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis
Authors: Serena Guiducci, Mirko Manetti, Marco Matucci-Cerinic
Journal: Annals of Internal Medicine (2011)

Letters5 July 2011Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic SclerosisSerena Guiducci, MD, Mirko Manetti, PhD, and Marco Matucci-Cerinic, MD, PhDSerena Guiducci, MDFrom University of Florence, 50139 Florence, Italy.Search for more papers by this author, Mirko Manetti, PhDFrom University of Florence, 50139 Florence, Italy.Search for more papers by this author, and Marco Matucci-Cerinic, MD, PhDFrom University of Florence, 50139 Florence, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-1-201107050-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Yun's observation that an immunosuppressive effect of expanded autologous MSCs may have contributed to the positive outcome in our patient with systemic sclerosis. Previous data suggest that subpopulations within MSCs may have an immunomodulating role in the host, without provoking immunologic responses from alloreactive T cells or other effector cells (1). Moreover, MSCs may also have a “regenerative” role, thus contributing to the repair of damaged vessels.Recent studies (2) have shown that MSCs derived from the bone marrow of patients with systemic sclerosis exhibit the same phenotypic, proliferative, and differentiation potential and immunosuppressive ...References1. Kassis I, Vaknin-Dembinsky A, Karussis D. Bone marrow mesenchymal stem cells: agents of immunomodulation and neuroprotection. Curr Stem Cell Res Ther. 2011;6:63-8. [PMID: 20955154] CrossrefMedlineGoogle Scholar2. Larghero J, Farge D, Braccini A, Lecourt S, Scherberich A, Foïs E, et al. Phenotypical and functional characteristics of in vitro expanded bone marrow mesenchymal stem cells from patients with systemic sclerosis. Ann Rheum Dis. 2008;67:443-9. [PMID: 17526552] CrossrefMedlineGoogle Scholar3. Meirelles Lda S, Fontes AM, Covas DT, Caplan AI. Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev. 2009;20:419-27. [PMID: 19926330] CrossrefMedlineGoogle Scholar4. Del Papa N, Quirici N, Soligo D, Scavullo C, Cortiana M, Borsotti C, et al. Bone marrow endothelial progenitors are defective in systemic sclerosis. Arthritis Rheum. 2006;54:2605-15. [PMID: 16868984] CrossrefMedlineGoogle Scholar5. Sorrell JM, Caplan AI. Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010;1:30. [PMID: 20863417] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Florence, 50139 Florence, Italy.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAutologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis Serena Guiducci , Francesco Porta , Riccardo Saccardi , Stefano Guidi , Lidia Ibba-Manneschi , Mirko Manetti , Benedetta Mazzanti , Simone Dal Pozzo , Anna Franca Milia , Silvia Bellando-Randone , Irene Miniati , Ginevra Fiori , Rossana Fontana , Laura Amanzi , Francesca Braschi , Alberto Bosi , and Marco Matucci-Cerinic Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis Jeong H. Yun Metrics 5 July 2011Volume 155, Issue 1Page: 65-66KeywordsAngiogenesisBone marrowCellsEndothelial cellsImmunosuppressivesMesenchymal stem cellsSclerodermaSystemic diseasesT cells ePublished: 5 July 2011 Issue Published: 5 July 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...