tbuckley/cabot-search huggingface dataset:
A case of leprosy with unusual cutaneous manifestations.
Authors: R. Lang, E. S. Benjamin, W. Gordon
Journal: British Journal of Dermatology (1965)

Journal Article A case of leprosy with unusual cutaneous manifestations. Get access R. Lang, R. Lang Cape Town Search for other works by this author on: Oxford Academic Google Scholar E. S. Benjamin, E. S. Benjamin Cape Town Search for other works by this author on: Oxford Academic Google Scholar W. Gordon W. Gordon Cape Town Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 8-9, 1 August 1965, Pages 470–472, https://doi.org/10.1111/j.1365-2133.1965.tb14679.x Published: 01 August 1965
Sampling strategies in nested case-control studies.
Authors: B Langholz, D Clayton
Journal: Environmental Health Perspectives (1994)

A stratified version of nested case-control sampling which we call "countermatching" is presented. This design uses data available for all cohort members to obtain a sample for collecting additional information in a case-control substudy. Hitherto the only stratified sampling design for such studies has involved matching of controls to cases with respect to confounding variables. However, in some situations, rather than sampling to make controls as similar as possible to cases, we might wish to make them as different as possible. This is achieved by the counter-matched design. Statistical analysis of counter-matched studies is straightforward using existing computer software. We investigate the use of the design when a surrogate measure of exposure is available for the full cohort, but accurate exposure data is to be collected only in a nested case-control study, and when exposure data are available for the whole cohort but data concerning important confounders are not. Asymptotic relative efficiency calculations indicate that a substantial efficiency gain relative to simple random sampling of controls can be expected in these situations. We also illustrate how the design might be implemented in practice.
Port Limon and Yellow Fever Reports.
Authors: Walter Wyman
Journal: JAMA (1901)

Treasury Department, Office of the Supervising Surgeon-General, Marine-Hospital Service, Washington, D. C., March 8, 1901. <h3>To the Editor:</h3> —InThe Journalof March 2, under "Correspondence," is a letter from Dr. Edmond Souchon, president of the Louisiana State Board of Health, which takes exception to some of the suggestions contained in a paper by Dr. Nicholas Senn, published inThe Journalof January 19. Dr. Souchon quotes Dr. Senn's suggestion of placing the port of New Orleans under the jurisdiction of the U. S. Marine-Hospital Service, etc., and makes the following statement: "This expression is most unfortunate, especially as coming so soon after the signal failure of the Marine-Hospital Service to recognize the existence of yellow fever in time at Port Limon last year. That service admitted the existence of the fever there several weeks only after the distinguished representative of the Louisiana State Board of Health, Dr. Will H.
REMOVAL OF A SAFETY PIN FROM THE STOMACH WITHOUT GASTROTOMY
Authors: W. Banks Huff
Journal: JAMA (1930)

The usual procedure for the removal of foreign bodies from the stomach is through a gastrotomy wound. It is my purpose in this article to describe a method by which it is possible to remove safety pins without making an opening into the stomach.  REPORT OF CASE  About 6 p. m., Nov. 14, 1929, while holding a girl, aged 6 months, in her arms, the mother was attracted by a peculiar noise made by the child as if she were strangling. She put a finger down the child's throat and was able to feel the tip of a safety pin, but could not grasp it. The child continued to show signs of choking for a few minutes, and breathed with difficulty. Then it became perfectly quiet and cried only when disturbed.  At the time of examination the child appeared to be in pain. The mouth and throat showed no evidence
Hair Analysis: What Does It Tell Us?
Authors: Paul Lazar
Journal: JAMA (1974)

In selected applications in forensic, clinical, or epidemiologic medicine, trace-metal hair analysis, along with other tests, is a useful tool. Nevertheless, present scientific knowledge does not support the use of metal levels in hair for broad, sophisticated, subtle diagnostic purposes (such as vitamin deficiencies, enzyme activity, and allergic states), and certainly, hair analysis is not desirable for routine use. The state of health of the body may be entirely unrelated to the physical and chemical condition of the hair. Hair can be mechanically damaged by rough drying procedures, brushing, combing, or pulling (as in the use of rollers). Chemically, hair can be altered during waving, straightening, dyeing, and bleaching; moreover, products such as "tonics," hair sprays, conditioning or grooming aids, or shampoos also influence the condition of the hair; lead, zinc, and selenium are deposited on the hair after the use of some of these preparations. There are not only
Lymphadenopathy-Associated Virus: From Molecular Biology to Pathogenicity
Authors: LUC MONTAGNIER
Journal: Annals of Internal Medicine (1985)

Recent data indicate that the lymphadenopathy-associated virus (LAV) is morphologically similar to animal lentiviruses, such as equine infectious anemia and visna viruses. This finding, together with the cross-reactivity of the core proteins of LAV with those of the equine infectious anemia virus and a similarity in genome structure and biological properties, allows LAV to be placed in the retroviral subfamily of Lentivirinae. Molecular data indicate a high degree of genetic variation of the virus, especially in the envelope gene, which have important implications for the origin of the virus (the T4 lymphotropism may be a recently acquired property) and for future immunization. Another problem is the role of viral infection in the induction of irreversible immunodeficiency. This syndrome occurs in a minority of infected persons, who generally have in common a past of antigenic stimulation and of immune depression before LAV infection.
Resuscitation of the newborn.
Authors: D G Moyes
Journal: BMJ (1980)

assess this.We should be told how many patients receiving long-term anti-inflammatory therapy were examined in order to find the 249 patients who had no gastric lesions at the initial endoscopy, incorrectly named the pretreatment endoscopy.If few were rejected this would support the view that the lesions are often transient.We do not accept the authors' reasons for not including a control group, and would suggest the use of paracetamol in a group with osteoarthrosis.This is an important area of work in which much more information is required, but we would reluctantly question the conclusions drawn by these workers.Further studies of better design should be undertaken.
Effects of relaxation on the delayed‐type hypersensitivity (DTH) reaction to diphenylcyclopropenone (DCP)
Authors: R. Zachariae, M. M. Jørgensen, S. Christensen, P. Bjerring
Journal: Allergy (1997)

Delayed‐type hypersensitivity (DTH) reactions to the experimental allergen diphenylcyclopropenone (DCP) were measured in four groups, which either trained (+) or did not train in relaxation (−) during the sensitization and/or the challenge phase. All groups consisted of high and low hypnotic susceptible subjects. While there were no differences in erythema, the mean induration of the group which trained in relaxation in both the sensitization and the challenge phase (+/+) was significantly greater than that of the group which trained in relaxation in the challenge phase only (−/+). Significant correlations were found between induration and hypnotic susceptibility scores, and between induration and degree of perceived relaxation during challenge. High hypnotic susceptible subjects experienced a higher degree of perceived relaxation and exhibited greater indurative and erythematous DTH reactions to DCP than low hypnotic susceptible subjects in all four experimental conditions. Though the mediating mechanisms remain unclear, our results suggest that relaxation may affect the DTH reaction, and support previous findings of higher psychophysiologic reactivity of high hypnotic susceptible subjects.
GMC clears surgeon of 22 charges
Authors: O. Dyer
Journal: BMJ (2001)

A UK consultant surgeon who had been accused of botching operations after which six patients died was cleared of serious professional misconduct last week after a long running inquiry by the General Medical Council.

Christopher Ingoldby, 54, is now free to return to work but remains out of a job after being sacked last summer by his employer, Pinderfields and Pontefract Hospitals NHS Trust, …
Seven Weeks to Better Sex
Authors: Marc Hale Hollender
Journal: JAMA (1995)

<b>Heterosexuality</b>, by William H. Masters, Virginia E. Johnson, and Robert C. Kolodny, 595 pp, with illus, paper, $16, ISBN 0-06-092600-7, New York, NY, HarperPerennial, 1994. <i>Seven Weeks to Better Sex</i>, a self-help book written in everyday language, is for couples seeking solutions to sexual problems. Dr Renshaw has drawn upon her rich clinical experience of almost a quarter of a century as director of the Loyola Sex Therapy Clinic to design this program. She acknowledges that no book can completely replicate the experience of attending a clinic, but she maintains that it is possible to derive substantial benefit from reading the book combined with exercises done at home. Dr Renshaw writes the way she speaks—animated and clear. Well-chosen case notes illustrate practically every point she makes. There is no jargon, and the few technical terms are defined immediately. Indebtedness is acknowledged to William Masters and Virginia Johnson, who developed many
Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357
Authors: Sorin Armeanu, Anita Pathil, Sascha Venturelli, Paolo Mascagni, Thomas S. Weiss, Martin Göttlicher, Michael Gregor, Ulrich M. Lauer, Michael Bitzer
Journal: Journal of Hepatology (2004)
Geriatric Bioscience: The Link Between Aging and Disease
Authors: William B. Hazzard
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immediate and delayed acupuncture reduced frequency and pain intensity of primary migraine or tension-type headaches
Authors: Gabriel Rada
Journal: Annals of Internal Medicine (2009)

ACP Journal Club20 January 2009Immediate and delayed acupuncture reduced frequency and pain intensity of primary migraine or tension-type headachesGabriel Rada, MDGabriel Rada, MDPontificia Universidad Católica de Chile, Santiago, Chile (G.R.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-2-200901200-02014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationJena S, Witt CM, Brinkhaus B, Wegscheider K, Willich SN. Acupuncture in patients with headache. Cephalalgia. 2008;28:969-79. https://pubmed.ncbi.nlm.nih.gov/18624803Clinical Impact RatingsGIM/FP/GP: Neurology: Reference1 Melchart D, Linde K, Fischer P, et al. Acupuncture for idiopathic headache. Cochrane Database Syst Rev. 2001;(1):CD001218. [PMID: 11279710] Google Scholar Author, Article, and Disclosure InformationAffiliations: Pontificia Universidad Católica de Chile, Santiago, Chile (G.R.)This article was published at Annals.org on 6 January 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 January 2009Volume 150, Issue 2Page: JC1-14KeywordsAcupunctureForecastingHealth insuranceHypertensionMeningoencephalitisMigraineNeurology ePublished: 20 January 2009 Issue Published: 20 January 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Epilepsy and Sports
Authors: Samuel Livingston
Journal: JAMA (1978)

<h3>To the Editor. —</h3> We would like to express our disapproval of the 1976 revision of the booklet<i>Medical Evaluation of the Athlete:</i>A<i>Guide</i>, which was prepared by the American Medical Association Committee on the Medical Aspects of Sports. We were stunned by its declaration that persons with a "convulsive disorder not completely controlled by medication" be automatically and summarily excluded from participation in collision (football, hockey, lacrosse, rugby), contact (baseball, basketball, soccer, wrestling), and noncontact (crew, cross-country, swimming, tennis, track, volleyball) sports. This prohibition is almost totally inconsistent with Committee statements of 1968 (206:1291, 1968) and 1974 (229:820, 1974). In 1968, the Committee stated that the epileptic patient whose seizures are under reasonable control "should be encouraged to participate in... any sports of interest with the exception of boxing, tackle football, ice hockey, diving, soccer, rugby, lacrosse, and other activities where chronic recurrent head trauma may occur." From
Synergistic Inhibition of Endochondral Bone Formation by Silencing Hif1α and Runx2 in Trauma-induced Heterotopic Ossification
Authors: Lin Lin, Qi Shen, Huijie Leng, Xiaoning Duan, Xin Fu, Changlong Yu
Journal: Molecular Therapy (2011)

Angiogenesis and osteogenesis are tightly coupled during bone development. We studied the effect of inhibition of Hif1α and Runt-related protein 2 (Runx2) on the formation of heterotopic ossification (HO). We constructed lentivirus vectors expressing Hif1α small interfering RNA (siRNA) and Runx2 siRNA. The inhibition of Hif1α function impaired osteoblast proliferation while osteoblasts differentiated normally. Osteoblasts lacking Runx2 proliferated normally while the differentiation was impaired. The osteoblast differentiation was significantly inhibited by co-Runx2 and Hif1α siRNA treatment. The formation of HO by inhibiting Runx2 and Hif1α in an animal model induced by Achilles tenotomy was investigated. The results showed that lacking of Runx2 and Hif1α could inhibit HO formation. Inhibition of Hif1α prevented HO formation only at the initial step and inhibition of Runx2 worked both at the initial step and after chondrogenesis. Angiogenesis and the expressions of osteogenic genes were downregulated in the Hif1α siRNA group. We found synergistic inhibition of endochondral bone formation by silencing Hif1α and Runx2. Our study provided new insight into the roles of Hif1α and Runx2 during the processes of endochondral bone formation, and had important implications for the new therapeutic methods to inhibit HO or to enhance bone formation.
Theophylline-Induced Behavior Change in Children
Authors: Bruce Bender
Journal: JAMA (1992)

To evaluate children who take theophylline for the presence of behavioral side effects and to determine whether the beliefs about these side effects held by their parents are supported by their own observations.A double-blind, placebo-controlled, randomized, crossover protocol. Under both study conditions the children completed tests that measured their attention, impulsivity, memory, activity level, and mood, while the parents rated their behavior.The subjects were 8- to 12-year-old children with asthma whose parents had observed adverse behavioral side effects while the children were taking theophylline. Among cited side effects were impulsivity, hyperactivity, altered mood, and impaired attention.No differences related to treatment could be detected from the parent questionnaires or from six of nine scores of the psychological evaluation of the children. The children, however, made fewer attention errors and showed a mild increase in anxiety and hand tremor of the dominant hand while they were receiving theophylline. All mean changes were small. No significant relationship was found between theophylline concentrations in the serum and degree of change in mood or attention. Eleven of 42 participants were disqualified for noncompliance during the study.Parental beliefs about the side effects experienced by their children are not supported by their own observations performed through a blinded protocol. These results are in conflict with reports of a high incidence of adverse behavioral side effects attributed to theophylline therapy.
HYPERSENSITIVENESS AND ANTIBODY FORMATION IN TUBERCULOUS RABBITS
Authors: Jules Freund, Elizabeth H. Laidlaw, James S. Mansfield
Journal: The Journal of Experimental Medicine (1936)

1. Rabbits infected with bovine tubercle bacilli develop hyper-sensitiveness to an intracutaneous injection of tuberculin. This sensitiveness appears from the 2nd to the 6th week after infection and increases rapidly thereafter. Tests, as a rule, show fluctuation in the intensity of the sensitization. Sensitization is followed by an interval of several weeks preceding death during which the animals fail to react. 2. Rabbits infected with bovine tubercle bacilli form antibodies that fix complement in the presence of tubercle bacilli. The antibodies appear after 2 weeks, increase during 6 to 10 weeks, and persist until the animals die. 3. In the later period of infection the skin fails to react to tuberculin at a time when the serum contains complement fixing antibodies.
CLINICAL INVESTIGATION OF CHLORPROMAZINE AND RESERPINE IN PRIVATE PSYCHIATRIC PRACTICE
Authors: A. E. BENNETT, F. R. FORD, R. E. TURK
Journal: American Journal of Psychiatry (1956)

One hundred and eighty private psychiatric patients received reserpine or chlorpromazine as well as standard psychiatric therapies. Of this number, 94 were hospitalized patients and 86 were office (ambulatory) patients. Results were disappointing from the standpoint of either drug producing a recovery, but encouraging in that they were superior to barbiturates in producing symptomatic improvement in anxiety, tension, manic and schizophrenic excitement, and mild insomnia. Depression per se was not alleviated by either drug. Usually, where one drug was found ineffective, so was the other. There were a few serious side-effects in our series: jaundice in 5 patients given chlorpromazine; 2 cases of cardiac collapse, and several cases of ankle and facial edema in those given reserpine. In general, neither reserpine nor chlorpromazine appeared to potentiate or interfere with standard psychiatric therapies. Six cases are singled out for special comment. In 2 cases of morphine addiction chlorpromazine administration prevented withdrawal symptoms. Alarming cardiac collapse occurred in 2 elderly patients on reserpine. In another case, exaggeration of former gastrointestinal symptoms appeared following reserpine administration. In the sixth case reserpine failed to control hypo-manic symptoms and probably potentiated postelectroshock confusion. The clinical nature of this study of private patients, the large proportion of whom were cases of depressive reactions, must be considered in the evaluation of results of the 2 drugs. From this clinical experience a study of the use of the drugs in selected cases is planned.
Wolfram Syndrome: Report of Four New Cases and a Review of Literature
Authors: L Fishman, R M Ehrlich
Journal: Diabetes Care (1986)

The Wolfram, or DIDMOAD, syndrome consists of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. Diabetes mellitus usually occurs as the first manifestation of this syndrome, followed by the development of optic atrophy, neurosensory hearing loss, and finally diabetes insipidus. We report on four cases with a review of the literature. The diabetes mellitus occurring in these patients is clinically indistinguishable rom classic type I diabetes mellitus. Two of three patients continue to have measurable C-peptide secretion 8 yr after onset of diabetes. Two of three patients with Wolfram syndrome had the HLA-DR2 antigen. Combining our cases with those described in the literature, 7 of 11 patients have the HLA-DR2 antigen. The preponderance of the HLA-DR2 antigen in the Wolfram syndrome is different from classic type I diabetes. This is further evidence of the genetic heterogeneity of diabetes mellitus. Although the Wolfram syndrome is rare, it should be considered in diabetic patients with unexplained optic atrophy and hearing loss or with polyuria and polydipsia in the presence of adequate blood sugar control.
A role for PKC in foam cell formation: reply
Authors: C.-S. Lin, L.-J. Ho, S.-P. Yang, J.-H. Lai
Journal: Cardiovascular Research (2012)

We would like to thank Drs Katka Szilagyi and Timo K. van den Berg for their interest and comments regarding our recent report.1 We also greatly appreciate sharing with their interesting and unpublished results about PKCδ.

Indeed, the approach with siRNA can result in changes in protein levels of certain untargeted genes that are unrelated to silencing of the targeted gene.2 However, in our study, we used different sequences of shRNAs or siRNAs against PKCδ which shared no cross-recognition with PKCβ in different cell models (THP-1 cells and human primary macrophages) and showed that knockdown of PKCδ reduced PKCβ protein expression. Interestingly, it has been shown that there is compensatory increases in PKCδ expression and activation in hearts of PKCɛ knock-out …