tbuckley/cabot-search huggingface dataset:
The Clinical Use of Sodium Fluoride F 18 in Bone Photoscanning
Authors: Norman F. Moon
Journal: JAMA (1968)

Thirty-eight patients were given 350μc to 750μc of sodium fluoride F 18. The nuclide was administered both orally and parenterally. Photoscans were performed in 35 cases, and point counts only were done in the other three. Diagnostic scans were found at all dosage levels given. Normal scans were found in cases of osteochondroma, soft-tissue sarcomas, rheumatoid spondylitis, Engelmann's disease, and aseptic necrosis of femoral heads. Abnormal scans were found in 25 cases including four cases of metastatic bone tumors in which roentgenograms were either normal or equivocal. The radionuclide has been found to be well tolerated. The radiation hazard with sodium fluoride F 18 is minimal, and serial scans have been performed successfully in several patients.
Ikaros family transcription factors in chronic and acute leukemia
Authors: Maja Matulic, Mladen Paradzik, Lipa Cicin‐Sain, Sanja Kapitanovic, Klara Dubravcic, Drago Batinic, Mariastefania Antica
Journal: American Journal of Hematology (2009)

Additional Supporting Information may be found in the online version of this article. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
EMOTIONAL REACTIONS OF AMERICAN SOLDIERS TO AN UNFAMILIAR DISEASE
Authors: JEROME D. FRANK
Journal: American Journal of Psychiatry (1946)

This survey indicates that patients suffering from unfamiliar diseases, of which schistosomiasis is an example, tend to develop emotional reactions which impede recovery, such as anxiety, resentment and confusion. To keep disability at a minimum, therapeutic efforts must be directed not only to overcoming the pathogenic agent but to maintaining the patient's confidence in the physician, and encouraging his expectation of return to useful activity.
Renal hemodynamic effects of l-arginine and sodium nitroprusside in heart transplant recipients
Authors: Jeanette Koller-Strametz, Michael Wolzt, Carola Fuchs, Dinah Putz, Wilfried Wisser, Christa Mensik, Hans-Georg Eichler, Günther Laufer, Leopold Schmetterer
Journal: Kidney International (1999)
Abstract A14: Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer
Authors: Aoife Ward, Aleksandra Balwierz, Jitao David Zhang, Moritz Kueblbeck, Stefan Wiemann, Thomas Hielscher, Yudi Pawitan, Ozgur Sahin
Journal: Clinical Cancer Research (2012)

Abstract Epithelial-mesenchymal transition (EMT) is an initiating event in tumor cell invasion and metastasis. It has been shown to occur in resistance to a range of cancer therapies, including tamoxifen. MicroRNAs (miRNAs) have been associated with EMT as well as resistance to standard therapies. To investigate the role of miRNAs in the development of resistance to tamoxifen as well as accompanying EMT-like properties, we established a tamoxifen resistant (TamR) model by continually exposing MCF-7 breast cancer cells to tamoxifen. In addition to the molecular changes known to be involved in acquired tamoxifen resistance, TamR cells displayed mesenchymal features and had increased invasiveness. Genome-wide miRNA microarray analysis revealed that miRNA-375 was among the top down-regulated miRNAs in resistant cells. Re-expression of miR-375 was sufficient to sensitize TamR cells to tamoxifen and partly reversed EMT. A combination of mRNA profiling, bioinformatic analysis, and experimental validation identified metadherin/MTDH as a direct target of miR-375. Knockdown of MTDH partially phenocopied the effects of miR-375 on the sensitivity to tamoxifen and the reversal of EMT. We observed an inverse correlation between the expression of miR-375 and its target MTDH in primary breast cancer samples, implying the pathological relevance of targeting. Finally, tamoxifen-treated patients with higher expression of MTDH had a shorter disease-free survival and higher risk of relapse. As most cancer-related deaths occur due to resistance to standard therapies and metastasis, re-expression of miR-375 or targeting MTDH might serve as potential therapeutic approaches for the treatment of tamoxifen resistant breast cancer.
INTEGUMENTARY ASSOCIATIONS OF PERNICIOUS ANAEMIA
Authors: RODNEY P. R. DAWBER
Journal: British Journal of Dermatology (1970)

Journal Article INTEGUMENTARY ASSOCIATIONS OF PERNICIOUS ANAEMIA Get access RODNEY P. R. DAWBER RODNEY P. R. DAWBER University Department of Dermatology and Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 3, 1 March 1970, Pages 221–223, https://doi.org/10.1111/j.1365-2133.1970.tb12428.x Published: 01 March 1970 Article history Accepted: 19 September 1969 Published: 01 March 1970
Biofeedback for pelvic floor dysfunction in constipation
Authors: G Bassotti, F Chistolini, F Sietchiping-Nzepa, G de Roberto, A Morelli, G Chiarioni
Journal: BMJ (2004)

<h3>Objective</h3> To present the postmortem neuropathologic report of a patient with a <i>CHCHD10</i> mutation exhibiting an amyotrophic lateral sclerosis (ALS) clinical phenotype. <h3>Methods</h3> A 54-year-old man without significant medical history or family history presented with arm weakness, slowly progressed over 19 years to meet the El Escorial criteria for clinically probable ALS with bulbar and respiratory involvement, and was found to have a <i>CHCHD10</i> p.R15L mutation. Postmortem neuropathologic examination took place including immunohistochemical staining with CHCHD10, and double immunofluorescence combining CHCHD10 with TDP43 and neurofilament was performed and the results were compared with normal controls and sporadic ALS cases. <h3>Results</h3> Postmortem examination of the <i>CHCHD10</i> mutation carrier showed severe loss of hypoglossal and anterior horn motor neurons, mild corticospinal tract degeneration, and a relative lack of TDP43 immunopathology. CHCHD10 immunohistochemistry for the 3 controls and the 5 sporadic ALS cases showed strong neuronal cytoplasmic and axonal labeling, with the <i>CHCHD10</i> mutation carrier also having numerous CHCHD10 aggregates within their anterior horns. These aggregates may be related to the CHCHD10 aggregates recently described to cause mitochondrial degeneration and disease in a tissue-selective toxic gain-of-function fashion in a CHCHD10 knock-in mouse model. The CHCHD10 aggregates did not colocalize with TDP43 and were predominantly extracellular on double immunofluorescence labeling with neurofilament. <h3>Conclusions</h3> The neuropathology of CHCHD10 mutated ALS includes predominantly lower motor neuron degeneration, absent TDP43 immunopathology, and aggregates of predominantly extracellular CHCHD10, which do not contain TDP43.
Studies on the Spread of Excitation through the Ventricular Myocardium
Authors: RAYMOND D. PRUITT, HIRAM E. ESSEX, HOWARD B. BURCHELL
Journal: Circulation (1951)

The speed at which the excitatory process spreads through a certain segment of the myocardial syncytium depends upon the orientation of the fibers in that segment to each other and to the point of origin of excitation. Spread down a strip of fibers of which the long axis is parallel to the long axis of the strip is rapid as compared with spread down a strip in which the fibers run at a right angle to the long axis of the strip. Endocardial activation is rapid, not because of the presence of Purkinje fibers, but because the subendocardial bands of myocardium form a network through which excitation can move rapidly along the long axis of the fibers. Spread across the septum in bundle-branch block and across the free wall of the left ventricle in the normally activated heart is slow because excitation is moving through fibers the long axis of which is prependicular to the advancing wave of excitation.
Hospital bed utilisation in the NHS and Kaiser Permanente
Authors: P Badrinath
Journal: BMJ (2004)

Editor—The NHS is a learning organisation, and the secretary of state for health recently warned the critics opposed to learning from other healthcare systems.1 Ham et al have been criticised for not presenting evidence for the conclusion that Kaiser's better bed utilisation is due to integration of care, active management, use of intermediate and self care, and leadership.2

According to the authors, one of them interviewed senior clinical and managerial staff and visited Kaiser facilities to gather data. It is hard to quantify this type of qualitative data. However, evidence shows that Kaiser's chronic care programme management has reduced emergency department visits.3 A randomised controlled trial in a Kaiser facility found that a multidisciplinary outpatient diabetes care management programme reduced both inpatient and outpatient utilisation.4 Kaiser is the market leader in providing and implementing self-management support for patients.5

In the 21st century the NHS should be open to new ideas and, with regard to Kaiser, should not throw the baby out with the bath water. To quote the health secretary, “To refuse to learn at all is to commit an institution to steady decline. The NHS is a strong powerful social force in British society. It has the capacity and the strength to learn from the market just as it has the capacity and strength not to copy it.”1

Political and managerial champions are as essential as clinical champions to deliver the best possible service, and we should not veto ideas simply because they originate from market economies.
David Alexander Pealing Cooke
Authors: D. Cooke, A. Elliott
Journal: BMJ (2002)

After working as an air raid precautions warden while at school, David Cooke joined the Royal Air Force as soon as he was able.He flew a full tour of 30 sorties before qualifying as a bomb disposal officer.Upon demobilisation in 1946 he went up to Liverpool University and, after qualifying, continued
Clinical Ophthalmology: A Systematic Approach
Authors: Benjamin H. Ticho
Journal: JAMA (1995)

While I was in medical school, my father, a general ophthalmologist practicing since the 1950s, often enticingly described his chosen field as a "gentleman's specialty." By this I think he referred to the delicacy of eye microsurgery, the intellectual crossroads of the organ between multiple branches of basic and clinical sciences, and the fact that ophthalmologists usually get good results. As usual, my father was right. He might have added, however, that ophthalmology is an artist's specialty. So much of ophthalmologic practice involves simple visual pattern recognition. I don't mean to minimize the cerebral machinations involved in deducing the cortical lesion responsible for a homonymous superior quadrantanopsia, or the technical skill required to peel a proliferative membrane off a diabetic's retina, or even the (often arduous) detective work required to figure out why a Medicare recipient doesn't like her new bifocal glasses. However, much of the challenging as well as
Capillary Anastomosis in Vena Caval Thrombosis
Authors: JONATHAN L. WILLIAMS, BETTY SIEG, LISA K. PREVATT
Journal: Clinical Nuclear Medicine (1986)

A 29-year-old woman presented with recurrent diffuse histiocytic lymphoma. Bilateral brachial venous catheters were placed for chemotherapy, which resulted in thrombotic occlusion of the superior vena cava. A lung scan with Tc-99m MAA (flow study and static images) demonstrated extensive collateral vessels in the upperthorax and trapping of particles in the right upper abdomen, anteriorly. A simultaneous liver scan with Tc-99m sulfur colloid (flow and delayed images) illustrated a normal liver with no other abnormal sites of tracer deposition. The accumulation of a lung imaging agent in the anterior abdominal wall was secondary to capillary anastomosis between the superior and inferior epigastric veins.
Cardiovascular Risk from Coxibs
Authors: M. J. Friedrich
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Making Sense of Asthma Genes
Authors: William Cookson, Miriam Moffatt
Journal: New England Journal of Medicine (2004)

There are two causes of asthma — the environment and genetic variants. Each cause accounts for about 50 percent of the risk of the disease. The power of the public databases and the methods of genotyping used in genetics mean that the discovery of genes and the genetic variation underlying the various forms of asthma is increasing quickly.Genetics concerns polymorphism (variation) in genes. The most obvious effects of polymorphisms appear when they alter protein coding sequences and cause mutations. However, most of the polymorphisms that cause common diseases alter gene function through more subtle mechanisms. Such mechanisms may affect . . .
Treatment of Down's Syndrome With the "U" Series of Drugs
Authors: Thomas S. Bumbalo, Henry V. Morelewicz, David L. Berens
Journal: JAMA (1964)

IN REPORTING RESULTS of his medical research and treatment of mongolism,<sup>1</sup>Turkel of Detroit summarized his results as follows: It was intended to bring the Mongoloid to a physical condition as nearly normal as possible using medication to favorably alter the inborn structural anomalies, something heretofore considered impossible. X-rays and photographs have demonstrated that it is possible when the "U" series of drugs are used. This first breakthrough in the medical treatment of mongoloids should now stimulate physicians to improve the treatment. In reporting the results of treatment of 60 patients with the "U" series of drugs to the Section of Medical Science at the Annual Meeting of the New Jersey Academy of Science on April 7, 1962, Turkel stated: Mongoloids and other types of physically and mentally retarded individuals can be brought to near-normalcy by the "U" series of drugs in a treatment which the physician can manage from his office while the patient remains at home.
Non-invasive prediction of pulmonary capillary wedge pressure
Authors: William L. Daley, Joseph Loscalzo, Christopher R. Gill, Joseph A. Vita, George E. Thibault, Costas T. Lambrew, Jonathan Freeman, G.V.R.K. Sharma, Patricia A. Woods, Kevin M. McIntyre
Journal: Journal of the American College of Cardiology (1991)
Inability to balance on one leg reflects risk of brain bleed, study shows
Authors: S. Mayor
Journal: BMJ (2014)

Being unable to balance on one leg for 20 seconds or longer is associated with early, asymptomatic changes to blood vessels in the brain that potentially indicate future stroke risk, a Japanese study of middle aged and older people has shown.1

“Our study found that the ability to balance on one leg is an important test for brain health,” said Yasuharu Tabara, the lead author and associate professor at the Center for Genomic Medicine at Kyoto University Graduate …
Medulloblastomics: the end of the beginning
Authors: Paul A. Northcott, David T. W. Jones, Marcel Kool, Giles W. Robinson, Richard J. Gilbertson, Yoon-Jae Cho, Scott L. Pomeroy, Andrey Korshunov, Peter Lichter, Michael D. Taylor, Stefan M. Pfister
Journal: Nature reviews. Cancer (2012)
Percutaneous Absorption of 1-Naphthol in Man
Authors: H. G. W. M. Hemels
Journal: British Journal of Dermatology (1971)

Journal Article Percutaneous Absorption of 1‐Naphthol in Man Get access H. G. W. M. Hemels H. G. W. M. Hemels Department of Dermatology University of Nijmegen Javastraat 104 Nijmegen The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue 5, 1 November 1971, Pages 494–495, https://doi.org/10.1111/j.1365-2133.1971.tb14064.x Published: 01 November 1971
Pre-eclampsia in pregnancies by different fathers: immunological studies.
Authors: J A Need
Journal: BMJ (1975)

Immunological studies were performed on a woman with severe pre-eclamptic toxaemia in a second pregnancy. This pregnancy followed a normal twin pregnancy by a different father four years earlier. Both fathers were also studied. In the mixed lymphocyte culture the patient's lymphocytes reacted eight times as strongly against father 2's cells as against those from father 1. If studies along these lines are performed when a women has toxaemic and non-toxaemic pregnancies by different fathers information may be obtained on immunogenetic aetiological factors which may be of more value than that derived from the study of large unselected populations.
Sociosexuality and sex ratio: Sex differences and local markets
Authors: John Lazarus
Journal: Behavioral and Brain Sciences (2005)

Operational sex ratio (OSR) is the correct sex ratio measure for predicting sociosexuality, but it is unclear whether this is the measure used. It would be valuable to know how OSR and sociosexuality correlate separately for males and females. The relationship between sociosexuality and OSR should also be examined with OSR measured at the local level of the mating market, where sex ratio must be having its psychological effects.
Localised pulmonary arteritis in rheumatoid disease
Authors: J Meier-Sydow
Journal: Thorax (1982)

Localised pulmonary artentis in rheumatoid disease SIR,-Drs JG Armstrong and RH Steele in their report "Localised pulmonary arteritis in rheumatoid disease" (April 1982, p313) write that acute fibrinoid arteritis local- ised to one area of the lung has not been described previ- ously as a manifestation of rheumatoid disease.May we draw your attention to our publications.?' 2 In these we described a case of a 56-year-old woman with seropositive rheumatoid arthritis and migrating pneumonia.The transthoracic biopsy revealed a necrotis- ing angiitis.The administration of corticosteroids resulted in a quick and complete cure of the pulmonary disease.We would consider this as a localised pulmonary manifestation of rheumatoid disease, although the localisation changed in the manner of a "migrating' infiltration.
The Diagnostic Doubts of Dr. Cabot
Authors: Oliver T. Osborne
Journal: JAMA (1913)

<h3>To the Editor:</h3> —Allow me to express my approval of Dr. Croftan's letter (The Journal, Jan. 11, 1913, p. 145) concerning Dr. Cabot's paper ("Diagnostic Pitfalls,"The Journal, Dec. 28, 1912, p. 2295). We all make mistakes, and we all have idiosyncrasies. Some men think it advisable to pose as pessimists concerning their own ability or accomplishments. They do not really desire people to rate them as they publicly rate themselves. We frequently see this pose in discussions, and sometimes among our patients, who are always running themselves down. They do not believe it themselves, and they really do not want any one else to believe it; often they are persons of ability. Only a small number of patients under treatment by any one physician die, and only a small proportion of those that die come to autopsy. If Dr. Cabot's findings were statistically correct, the majority of our patients
Expression of iNOS, eNOS, and peroxynitrite-modified proteins in experimental anti-myeloperoxidase associated crescentic glomerulonephritis
Authors: Peter Heeringa, Harry van Goor, Han Moshage, Pieter A. Klok, Minke G. Huitema, None Alie de Jager, Anja J. Schep, Cees G.M. Kallenberg
Journal: Kidney International (1998)
144 SUPPRESSION OF SERUM HCV RNA LEVELS DURING MAINTENANCE PEGINTERFERON (PEGIFN) ALFA-2A THERAPY AND CLINICAL OUTCOMES IN THE HALT-C TRIAL
Authors: M.L. Shiffman, C. Morishima, K.L. Lindsay, J.C. Hoefs, J.L. Dienstag, G. Szabo, W.M. Lee, E.C. Wright
Journal: Journal of Hepatology (2008)
The Treatment of Cancer Pain
Authors: Kathleen M. Foley
Journal: New England Journal of Medicine (1985)

ADVANCES in the diagnosis and treatment of cancer, coupled with an expanded understanding of the physiology, pharmacology, and psychology of pain perception, have led to improved care of the patient with pain from cancer.1 Improved methods of cancer diagnosis and treatment provide the best approach to managing pain by treating its cause. Before the start of antitumor therapy or when such therapy is unsuccessful or irreversible injury to bone, soft tissue, or nerve has occurred, however, adequate pain control is essential.Management of pain in patients with cancer requires specific expertise that includes a knowledge of the clinical pain syndromes . . .
DUAL CT AND MRI IN VIVO TRACKING OF STEM CELL THERAPY IN PERIPHERAL ARTERY DISEASE
Authors: Yibin Xie, Yingli Fu, Ronald Ouwerkerk, Steven M. Shea, Tina Ehtiati, Dorota Kedziorek, Gary Huang, Wesley D. Gilson, Meiyappan Solaiyappan, Robert Krieg, Dara L. Kraitchman
Journal: Journal of the American College of Cardiology (2010)
Asthma in medium altitude – exercise‐induced bronchoconstriction in hypobaric environment in subjects with asthma
Authors: S. Berntsen, T. Stensrud, F. Ingjer, A. Vilberg, K.‐H. Carlsen
Journal: Allergy (2005)

Background: Hypoxic gas inhalation has been reported to enhance airway responsiveness and results in bronchoconstriction in animal models and in humans with asthma. However, the data have so far been conflicting. The aim of the present study was to examine the effect of reduced barometric pressure on exercise‐induced bronchoconstriction (EIB) in subjects with asthma. Methods: Twenty subjects (10–45 years old, ♂/♀ = 13/7) with asthma (at least 10% reduction in forced expiratory volume in 1‐second postexercise) participated in exercise testing in barometric pressure corresponding to altitudes of 200 (normobaric) and 2500 (hypobaric) m above sea level in random order on separate days. Lung function was measured before and after exercise, as well as after inhalation of salbutamol. Heart rate, oxygen uptake ( ), arterial oxygen saturation (S p O 2 ), respiratory gas exchange ratio (RER) and minute ventilation ( ) were measured during exercise. Results: There was no difference in lung function after exercise. The and HR peak during exercise did not differ. The RER peak was higher ( P = 0.04) in hypobaric environment. The decreased 10.1% (7.2–13.0) [mean (95% confidence intervals)] ( P &lt; 0.001) from normobaric to hypobaric environment. At the same time, S p O 2 at decreased from 94.4 (92.2–96.6) to 85.6% (82.8–88.4) ( P &lt; 0.001). Conclusions: A barometric pressure corresponding to altitude of 2500 m did not increase EIB in subjects with asthma. The reduction in is most probably due to the lower S p O 2 in hypobaric environment.