tbuckley/cabot-search huggingface dataset:
Long-term T-cell reconstitution after hematopoietic stem-cell transplantation in primary T-cell–immunodeficient patients is associated with myeloid chimerism and possibly the primary disease phenotype
Authors: Marina Cavazzana-Calvo, Frédérique Carlier, Françoise Le Deist, Estelle Morillon, Pierre Taupin, David Gautier, Isabelle Radford-Weiss, Sophie Caillat-Zucman, Bénédicte Neven, Stephane Blanche, Rémi Cheynier, Alain Fischer, Salima Hacein-Bey-Abina
Journal: Blood (2007)
Home Delivery — Bringing Primary Care to the Housebound Elderly
Authors: Susan Okie
Journal: New England Journal of Medicine (2008)

Nurse practitioner Gail Metcalf toted her medical bag up the steep stairway of a triple-decker house in Dorchester, a low-income neighborhood of Boston, and greeted her patient, Mrs. E, a Jamaican woman in her mid-80s. Mrs. E, who is legally blind and has chronic obstructive pulmonary disease, hypertension, neuropathy, a thoracic aneurysm, and other medical problems, sank into a lift chair and began describing her symptoms as Metcalf examined her. Her back ached and her arms burned, she said, especially at night: “That's the time when it really comes on. Sometimes, I feel life is leaving me.”Mrs. E's agitation . . .
Retrospective review of care and outcomes in young adults with type 1 diabetes
Authors: C J Wills
Journal: BMJ (2003)

smoke but, as there are no data directly relating cotinine levels to risk of death, it is not possible to predict the likely effect of a reduction of this magnitude on the risk of sudden infant death.Our results also suggest that harm reduction measures short of a total ban on smoking in the home are likely to have little effect on the exposure of infants to tobacco smoke, but this requires verification with a larger sample.We thank the parents who participated; the health visitors, their managers, and staff in the child health departments of the NHS trusts who helped us to recruit our sample; and the nurses who collected the data.Contributors: See bmj.com
Renal and Perirenal Gas in a Diabetic Man
Authors: James F. Murphy, Herbert L. Fred, Victor Carlson
Journal: JAMA (1977)

<h3>History</h3> A 64-year-old diabetic man experienced back pain, fever, chills, and dyspnea for one week. On examination, his rectal temperature was 38 C; pulse rate, 120 beats per minute; and respiratory rate, 30/min. He had distended neck veins, a ventricular gallop, dullness to percussion at the base of each lung, peripheral edema, and tenderness in his right flank. Total leukocyte count was 19,900/cu mm; blood glucose concentration, 319 mg/100 ml; and BUN level, 88 mg/100 ml. Urine gave a 1 + glucose reaction and contained 70 to 100 WBCs and numerous bacilli per high power field. Cultures of blood and urine grew<i>Escherichia coli</i>. Roentgenographic studies include a chest film (Fig 1) and anteroposterior and lateral abdominal films (Fig 2 and 3). <h3>Diagnosis</h3> Emphysematous pyelonephritis with perinephric abscess and emphysematous cystitis. <h3>Comment</h3> The chest film depicts pulmonary vascular congestion, bilateral pleural effusions, infiltrates in both lower lobes, and gas partially outlining
Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma
Authors: A. G. Oehling, C. A. Akdis, A. Schapowal, K. Blaser, M. Schmitz, H.‐U. Simon
Journal: Allergy (1997)

The effect of systemic glucocorticoid therapy on immune parameters was studied in patients with bronchial asthma. Patients were divided into two groups: 1) those receiving oral glucocorticoid; 2) control patients who did not receive systemic glucocorticoid treatment. The glucocorticoid dose varied between 5 and 70 mg per day. Patients had been taking oral therapy for at least 1 year. Glucocorticoid treatment was associated with an increased frequency of respiratory tract infections. Therefore, we need to define immune parameters which may predict an increased risk of infections. In this study, we analyzed several surface markers on lymphocytes and monocytes by flow cytometry. A significant reduction of the ratio of peripheral blood CD4+ to CD8+ T cells was associated with the administration of oral glucocorticoids. Furthermore, the expression of the HLA-DR molecule on monocytes was reduced in patients with systemic glucocorticoid therapy compared to control patients. Moreover, the capacity to elaborate cytokines by peripheral blood mononuclear cells upon stimulation was greatly reduced after exposure to glucocorticoids in vivo and in vitro. In addition, the humoral immune response was affected, because reduced IgG, IgM, and IgA levels were observed in patients receiving oral glucocorticoids. These results indicate that systemic glucocorticoid treatment in patients with bronchial asthma is associated with cellular and humoral immunosuppression which results in an increased risk of bacterial and viral infections.
Effect of Acarbose on Carbohydrate and Lipid Metabolism in NIDDM Patients Poorly Controlled by Sulfonylureas
Authors: Gerald M Reaven, Claude K Lardinois, Michael S Greenfield, Herbert C Schwartz, Hendrick J Vreman
Journal: Diabetes Care (1990)

The ability of acarbose to lower plasma glucose concentration was studied in 12 patients with non-insulin-dependent diabetes mellitus (NIDDM) who were poorly controlled by diet plus sulfonylurea drugs. Patients were studied before and 3 mo after the addition of acarbose to their treatment program, and a significant improvement in glycemic control was noted. Although the decrease in fasting plasma glucose concentration was modest (12.0 +/- 0.8 to 10.8 +/- 0.3 mM), average postprandial plasma glucose concentration decreased by 3.4 mM. When acarbose therapy was discontinued in 5 patients, plasma glucose levels rapidly returned toward pretreatment levels. In addition to the improvement in glycemia, acarbose treatment also led to a significant reduction in HbA1c (7.4 +/- 0.2 to 6.4 +/- 0.2%, P less than 0.01) and triglyceride (2.4 +/- 0.1 to 2.1 +/- 0.1 mM, P less than 0.01) concentrations. Neither the plasma insulin response to meals nor insulin-stimulated glucose uptake improved with acarbose therapy, consistent with the view that acarbose improves glycemic control by delaying glucose absorption. Considerable individual variation was noted in the response to acarbose, and the results in 4 patients were dramatic, with striking reductions in both fasting and postprandial glucose concentrations. The addition of acarbose to patients with NIDDM not well controlled by sulfonylureas appears to have significant clinical benefit.
Chronic Obstructive Pulmonary Disease: A Growing but Neglected Global Epidemic
Authors: Peter J Barnes
Journal: PLoS Medicine (2007)

Chronic obstructive pulmonary disease (COPD) is a major and increasing global health epidemic that has received insuffi cient attention from the health-care profession, governments, and the pharmaceutical industry.Urgent action is now required to recognise the disease, predicted to soon become one of the major causes of death and disability, and to develop more effective prevention and treatment strategies. Chronic Obstructive Pulmonary Disease: A Growing but Neglected Global EpidemicPeter J.
A Day in the Life of a Corporate Retail Pharmacist
Authors: Tina Penick Brock
Journal: Annals of Internal Medicine (2014)

Letters7 January 2014A Day in the Life of a Corporate Retail PharmacistTina Penick Brock, EdDTina Penick Brock, EdDFrom University of California, San Francisco, San Francisco, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5000 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dore's essay (1) certainly represents a composite case of what can be wrong with the job of a “corporate retail” pharmacist; however, I contrast the account of his first pharmacy job with that of my own at Medical Center Pharmacy. It was in a small town in an underserved state, and the pharmacy was staffed by 2 pharmacists who had completed bachelor's degrees in pharmacy and a technician who trained via the apprenticeship model. It, too, had a mirrored wall left from the soda fountain days. But we had great rapport with the local medical community and ...Reference1. Dore DD. A day in the life of a corporate retail pharmacist. Ann Intern Med. 2013;159:366-7. [PMID: 24026322] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Tina Penick Brock, EdDAffiliations: From University of California, San Francisco, San Francisco, California.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L13-1072. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Day in the Life of a Corporate Retail Pharmacist David D. Dore Metrics 7 January 2014Volume 160, Issue 1 Page: 70 Keywords Conflicts of interest Health care Health care providers Life expectancy Patients Pharmacists Prevention, policy, and public health Technicians ePublished: 7 January 2014 Issue Published: 7 January 2014 PDF downloadLoading ...
Data Needed for National Study of Internal Medicine Manpower
Authors: ALVIN R. TARLOV
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 August 1981Data Needed for National Study of Internal Medicine ManpowerALVIN R. TARLOV, M.D.ALVIN R. TARLOV, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-2-236_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Internal medicine subspecialty fellowship training programs in the United States are listed in Directory of Training Programs in Internal Medicine: Residency and Subspecialty Fellowships, published by the Association of Professors of Medicine in Washington, 1979. The directory was distributed to all directors of approved residency training programs in internal medicine and to all directors of subspecialty fellowship training programs and has been used by residents and others who need information on the existence and location of the various programs.To update the listing for 1981-1982 we need the help of program directors to identify the beginning of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Chicago Chicago, IL 60637 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1981Volume 95, Issue 2Page: 236-236KeywordsFellowshipsResidencySub-specialty care Issue Published: 1 August 1981 PDF DownloadLoading ...
Fearful of Shadows
Authors: Charles Hamilton
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ST. GEORGE'S HOSPITAL: ENDOCARDITIS: ANAeMIA: REMARKABLE SLOWNESS OF PULSE: WITH REMARKS
Authors: G. G. Rogers
Journal: BMJ (1856)

My attention having been lately directed to endocarditis, I found the two following cases amongst my notes; and although a year has elapsed since their occurrence, they are not the less deserving of record.CASE I. (Under the care of Dr. BEXCE JOINES.)H
Useful information about rare inherited disorders
Authors: M. A Patton
Journal: BMJ (2003)

Rare disorders from Aarskog syndrome to the Zellweger syndrome do not appear in standard textbooks. Although individually rare, such inherited disorders number in thousands when considered together and form a significant proportion of disease. A patient with one of these disorders is likely to be seen in general practice from time to time. Fortunately for practitioners, several sources for reference now exist that could help in the management of patients and their families.

The charitable sector often provides a good source of information for both patients and professionals. The charity Contact a Family (www.cafamily.org.uk/) has pioneered this with its first directory, published in 1991.1 Hard copies on paper or on CD are available from the charity. This …
LEUCOPLAKIC VULVITIS AND ITS RELATION TO KRAUROSIS VULVAE AND CARCINOMA VULVAE
Authors: C. Berkeley, V. Bonney
Journal: BMJ (1909)

It was assamed that acid production, or bacterial activity, terminated as a result of the lactose (milk sugar) -contained in the milk having all become converted into lactic acid.To ascertain if the addition of lactose would accelerate acid production, two cultures were made, (a) containing two tablets in 100 c.cm. of milk, (b) con- taining two tablets in 100 c cm. of milk, with the addition of 4 grams of lactose; after seven days' incubation at 1000 F., the amount of lactic acid produced in (a) and (b) was found to be identical-namely, 3 12 per cent. in each sample.It therefore appears that the addition of milk sugar was unnecessary.Another question was, Does the curd or the whey contain the greater proportion of acid ?A sample of soured milk was examined, in which no separation of casein had occurred; it was afterwards heated in a flask or a water bath for a few minutes, until coagulation had taken place, for a sufficient quantity of whey to be obtained, and the -estimation of the acid in both instances was found to -correspond exactly. EFFECT OF TEMPERATURE.With a view of ascertaining the optimum temperature ,for the lactic acid organism, a sample of milk treated with 'the bacillus of Massol was divided into three parts, and ,the following results were obtained in the same length of iUme:Temperature.
United States Pharmacopeia Changes of Character
Authors: Chauncey D. Leake
Journal: JAMA (1965)

To the Editor:—  The tone of the publicity recently released by officials of the United States Pharmacopeia Revision Committee suggests that these officials may be inadvertently changing the character and function of our pharmacopeia.  Pharmacopeias originated in the 16th century for providing physicians, pharmacists, and public officials with reasonable standards by which commonly used drugs could be identified, their purity estimated, and adulteration detected. Drug manufacturers could then offer an implied warranty by labeling their products with the drug name followed by the pharmacopeial reference, eg, chloroform, USP  This would indicate that the product conformed to the specifications given inUSP XI. The pharmacopeia, by giving the accepted standards, would make it possible for physicians, pharmacists, or governmental officials to check the product, and thus would assure that the manufacturer was offering a product that truly conformed to the standard.  Pharmacopeial standards are important for commonly used drugs. The
Prophylaxis of Hemophilus influenzae Type b Disease
Authors: Jeffrey D. Band
Journal: JAMA (1984)

<h3>To the Editor.—</h3> We appreciate Drs Murphy and Osterholm sharing data from their recent abstracts on rates of secondary disease in day-care center contacts of a case of<i>Hemophilus influenzae</i>disease.<sup>1</sup>They interpret these findings as suggesting that, in analyzing the impact of rifampin for prevention of secondary disease in the collaborative study,<sup>2</sup>one should consider day-care centers and households separately. However, there is an appropriate way to analyze the data from the collaborative study that takes into consideration the possibility of different rates of secondary disease, as well as the small numbers in some of the categories. This exact test for combining 2×2 tables computes the overall efficacy of rifampin and its statistical significance while analyzing household contacts separately from day-care classroom contacts.<sup>3</sup>Stratified for site of exposure, the effect of rifampin was significant in the group of contacts as a whole (<i>P</i>=.028) and in
The Control of Hypertension
Authors: Morton D. Bogdonoff
Journal: JAMA (1973)

The treatment of arterial hypertension with a variety of drugs is reviewed by George Aagaard, MD, in a special summary designed to highlight the various pharmacologic options available to the physician. But the treatment of the patient, of course, is predicated on the fact that the individual already knows he has hypertension and wants the physician to do something about it. That state of affairs— clear identification of the existence of an elevated blood pressure and a firm commitment by both the patient and the physician to see to it that the blood pressure is lowered —is, unfortunately, not the rule, but rather the exception. Epidemiologic surveys repeatedly indicate that at least one half of all individuals who are found to have arterial hypertension do not know it at the time the survey is conducted. Thus, it has been argued that a prior consideration for those interested in treating hypertension
Minority Faculty and Academic Rank in Medicine
Authors: Anita Palepu
Journal: JAMA (1998)

Previous studies have found that fewer minority medical school faculty hold senior professorial ranks than do majority faculty and may not be promoted as rapidly.To determine whether minority faculty were as likely as majority faculty to have attained senior rank (associate professor or full professor) after adjusting for other factors that typically influence promotion.A self-administered mailed survey of US medical school faculty using the Association of American Medical Colleges database. The sample was stratified by department, graduation cohort, and sex.A stratified random sample of 3013 full-time faculty at 24 representative US medical schools. All underrepresented minority faculty at these schools were sampled.Attainment of senior academic rank (associate professor or full professor).Of 3013 faculty surveyed, 1807 (60.0%) responded, including 1463 white (81.0%), 154 black (8.5%), 136 Asian (7.5%), and 54 Hispanic (3.0%). Overall, 980 faculty (54%) had attained senior academic rank, including 47 (30.5%) of 154 black faculty, 59 (43.4%) of 136 Asian faculty, 22 (40.8%) of 54 Hispanic faculty, and 852 (58.3%) of 1463 white faculty. White faculty had significantly more first-authored and total peer-reviewed publications than the other groups. After adjusting for the medical school, department, years as medical school faculty, number of peer-reviewed publications, receipt of research grant funding, proportion of time in clinical activities, sex, and tenure status, we found that the odds ratios of holding senior rank relative to white faculty were 0.33 (95% confidence interval [CI], 0.17-0.63) for black faculty, 0.36 (95% CI, 0.12-1.08) for Hispanic faculty, and 0.58 (95% CI, 0.30-1.12) for Asian faculty.Minority faculty were less likely than white faculty to hold senior academic rank. This finding was not explained by potential confounders such as years as a faculty member or measures of academic productivity.
MANAGEMENT OF ACUTE DISORDERS OF THE BILIARY TRACT
Authors: William D. Holden
Journal: JAMA (1952)

Two years ago, Ogilvie,1in an address to the Western Surgical Association, stated that he had never seen a case of acute cholecystitis in which the gallbladder burst, nor had he heard of one in the wards of the hospital in which he had worked for 40 years. This is a rather striking statement from a surgeon with his experience, and it was used as part of his criticism of early cholecystectomy for acute cholecystitis.  There is no doubt that there has been a tremendous interest in this subject among the members of the medical profession in this country during the last 20 years. A good number of surgeons have advocated early operation in acute cholecystitis and have presented statistical data to corroborate and implement their proposal. This has provoked but a small amount of criticism. It becomes important to determine, now that several years have elapsed since early cholecystectomy
Suicide hotline to be set up for Australian doctors
Authors: C. Zinn
Journal: BMJ (1997)

A special hotline to help doctors at risk of committing suicide is a priority recommendation in a damning report into Australian doctors' mental health.

The joint report, from the New South Wales Department of Health and the state's branch of the Australian Medical Association, found that 21 known suicides since 1992 were only the “tip of the iceberg.”

It said that …
Precise cause of Smith-Lemli-Opitz syndrome found
Authors: T. Sheldon
Journal: BMJ (1998)

Researchers at Amsterdam's Academic Medical Center claim to have found the precise cause of Smith-Lemli-Opitz (SLO) syndrome, which affects between one in 20 000 and one in 40 000 babies, often resulting in multiple congenital abnormalities.

Results published in the latest issue of the American Journal of Human Genetics (1998;63:329-38) show that SLO syndrome is caused by mutations in the gene coding of enzyme 7 dehydrocholesterol reductase (7-DHCR), which stimulates the biosynthesis of cholesterol, lacking in all patients with the syndrome.

Researchers were able to identify …
Pulseless Disease due to Branchial Arteritis
Authors: BOHDAN J. KOSZEWSKI, THEODORE F. HUBBARD
Journal: Circulation (1957)

A case of pulseless disease or branchial arteritis is described and findings of arteriography and arterial biopsy are observed. The primary lesion seems to consist of an acute neutrophilic periarteritis progressing to panarteritis, causing arterial thrombosis. Later stages are characterized by fibroblastic hypertrophy of adventitia with lymphocytic and plasmacellular infiltrations. The anatomic changes are characteristic enough to regard the condition as an independent syndrome that can usually be well differentiated from other inflammatory and degenerative arterial diseases. The arteritis in this case seemed to respond to combined steroid and anticoagulant therapy.
A CASE OF RENAL TUBERCULOSIS.
Authors: JOHN C. SPENCER
Journal: JAMA (1906)

<h3>Patient.</h3> —F. M., male, aged 33, carpenter, native of the United States. <h3>Family History.</h3> —The cause of the father's death is unknown, although he lived to an advanced age. Mother died of mammary cancer. One brother died from pulmonary tuberculosis. <h3>Personal History.</h3> —The patient had gonorrhea in early youth. About twelve years ago he had apparently a first attack of appendicitis. Symptoms continued for about five days and then subsided. The patient has always been rather susceptible to "colds," with a vague history of having had one or two very persistent attacks. Six years ago he had a pleurisy with effusion, which necessitated my removing about 500 c.c. of clear fluid from the left pleural sac. Convalescence was uneventful. About four years ago I operated on him for perityphlitic abscess caused by ruptured and partly gangrenous appendix. During the first week fragments of a fecal concretion about the size and