tbuckley/cabot-search huggingface dataset:
Is There a Role for Peptide Receptor Radionuclide Therapy in Medullary Thyroid Cancer?
Authors: Fernanda Vaisman, Paulo Henrique Rosado de Castro, Flavia Paiva Proença Lobo Lopes, Daniel Barretto Kendler, Cencita H.N. Pessoa, Daniel Alves Bulzico, Douglas de Carvalho Leal, Bruno Vilhena, Mario Vaisman, Michel Carneiro, Rossana Corbo
Journal: Clinical Nuclear Medicine (2014)

Medullary thyroid cancer (MTC) is a rare but potentially life-threatening disease with limited therapeutic options. As a neuroendocrine tumor, MTC expresses somatostatin receptors, and therefore, somatostatin-labeled radiopharmaceuticals could be used to treat patients with MTC.The aims of this study were to evaluate tumor shrinkage after Lu-DOTATATE treatment, to analyze the impact on quality of life as accessed by the SF-36 questionnaire, and to demonstrate a possible prognostic role for In-DTPA-octreotide uptake in patients with MTC.Patients with progressive MTC underwent evaluation using In-DTPA-octreotide. Patients who demonstrated In-DTPA-octreotide uptake were treated with 4 cycles of 200 mCi of Lu-DOTATATE and were evaluated using CT scans over 8 to 12 months of treatment.Of the 16 patients initially enrolled, 9 (56.25%) had lesions that were observed in the In-DTPA-octreotide scans and were eligible for therapy with Lu-DOTATATE. Three patients had a partial response, 3 patients were classified as having stable disease and, 1 patient had a progressive disease. All responders indicated improvement in quality of life 6 to 12 months after therapy.Treatment with Lu-DOTATATE seems to be an alternative therapy for somatostatin receptor-positive tumors, with very mild adverse effects and quality-of-life improvement, at least during a short-term period. Further studies are needed to determine long-term benefits and to identify which patients are more likely to respond to this modality of therapy.
Some patients seem not to have been included in census
Authors: A. J Munro, M. Chambers, A. Marwaha
Journal: BMJ (2001)

EDITOR—Target payments to health authorities and primary care trusts are based on the number of people recorded as living in the area in the national census. Discrepancies between this figure and the number recorded as being on general practitioners' lists puts pressure on health authorities to have patients removed from lists if the authorities believe that they no longer live at the address at which they are registered.

Our …
Asia takes action on drug-resistant tuberculosis
Authors: David Brill
Journal: The Lancet Infectious Diseases (2008)

Africa and eastern Europe have largely dominated recent attention around strengthening tuberculosis control, but Asia could yet prove the decisive battleground in the international war on the disease. At a gathering of countries from WHO's Western Pacific Region (WPR) in Tokyo (July 22–24) Pieter van Maaren, regional advisor for tuberculosis (WHO, Manila, Philippines), accused Asian nations of complacency, saying: "if we are going to avoid a public-health disaster, we have to accelerate action".
Exacerbation of bleeding tendency in a patient with haemophilia A, during treatment with isotretinoin
Authors: G.M. Dootson, J. Keidan, J.A.R. Anderson
Journal: British Journal of Dermatology (1992)

Journal Article Exacerbation of bleeding tendency in a patient with haemophilia A, during treatment with isotretinoin Get access G.M. Dootson, G.M. Dootson Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar J. Keidan, J. Keidan Haematology, Queen Elizabeth Hospital King's Lynn, Norfolk PE30 4ET, UK Search for other works by this author on: Oxford Academic Google Scholar J.A.R. Anderson J.A.R. Anderson Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 2, 1 August 1992, Pages 186–187, https://doi.org/10.1111/j.1365-2133.1992.tb08056.x Published: 01 August 1992
Long-Term Outcome of Renal Transplant Recipients in the United States After Coronary Revascularization Procedures
Authors: Charles A. Herzog, Jennie Z. Ma, Allan J. Collins
Journal: Circulation (2004)

Retrospective studies in dialysis patients have reported increased survival after coronary artery bypass (CAB) compared with coronary artery stenting and PTCA. The purpose of this study was to compare the long-term outcome of renal transplant recipients after stent, PTCA, or CAB with or without internal mammary grafting (CAB [IMG+] or CAB [IMG-]).Renal transplant recipients hospitalized from 1995 to 1999 for first coronary revascularization procedure were retrospectively identified from the United States Renal Data System database. Event-free survival for the end points of all-cause death, cardiac death, acute myocardial infarction (AMI), and the combined end point of cardiac death or AMI was estimated by the life-table method. The impact of independent predictors on survival was examined in a comorbidity-adjusted Cox model. In-hospital mortality rate was 2.3% for 909 stent patients, 4.3% for 652 PTCA patients, 9.4% for 288 CAB (IMG-) patients, and 5.0% for 812 CAB (IMG+) patients. Two-year all-cause survival (+/-SE) was: stent, 82.5+/-2.8%; PTCA, 81.6+/-3.1%; CAB (IMG-), 74.4+/-5.4%; and CAB (IMG+), 82.7+/-2.8%. The relative risks of all-cause and cardiac death were not significantly different among revascularization groups. The relative risk of cardiac death or AMI (versus PTCA) was 0.90 (95% CI, 0.69 to 1.17) for stent, 0.80 (95% CI, 0.55 to 1.17) for CAB (IMG-), and 0.57 (95% CI, 0.42 to 0.76) for CAB (IMG+).Renal transplant recipients in the United States have comparable long-term survival after percutaneous and surgical coronary revascularization procedures. The most favorable long-term outcome occurs after surgical coronary revascularization.
Diseases of the Genito-Urinary Organs and the Kidney.
Authors: Robert Holmes Greene, Harlow Brooks
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Representation of overseas and women doctors
Authors: S. Roy-Chowdhury
Journal: BMJ (1982)

hospital sectors" should also be adopted.For, while no one should denigrate the British achievement in supporting people in their own homes, there can be no argument but that this virtue is abused when prolonged into necessity and where alternative (residential) care becomes desirable but is not available.Part III homes already accommodate many disabled and potentially disturbed residents.Given more staff, including more appropriately trained staff, it is likely that these local care centres would cater for all but a very few very difficult long-term patients/residents and facilitate family support of frail old people still in private households.The role of sheltered housing as a caring rather than a housing resource seems to us unproved,3 and money spent in this sector is less likely to influence the lives of the very impaired elderly that give rise to the greatest concern.
How do people choose between local and global bookkeeping?
Authors: George Ainslie
Journal: Behavioral and Brain Sciences (1996)

Abstract The matching law accounts for both addictive behavior and the usefulness of a person's evaluating choices in overall categories. To explain why overall bookkeeping, once learned, does not easily win out over local bookkeeping, another implication of matching is needed: intertemporal bargaining. The role of melioration, though probably important for new addiction is separate.
17-DMAG targets the nuclear factor-κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition
Authors: Erin Hertlein, Amy J. Wagner, Jeffrey Jones, Thomas S. Lin, Kami J. Maddocks, William H. Towns, Virginia M. Goettl, Xiaoli Zhang, David Jarjoura, Chelsey A. Raymond, Derek A. West, Carlo M. Croce, John C. Byrd, Amy J. Johnson
Journal: Blood (2010)
Psychological factors related to prehospital delay during acute myocardial infarction.
Authors: L W Kenyon, M W Ketterer, M Gheorghiade, S Goldstein
Journal: Circulation (1991)

Prior studies have had difficulty identifying factors that significantly explain patients' delay in responding to symptoms of acute myocardial infarction (AMI).We therefore examined factors affecting the time between symptom onset and hospital arrival for 103 AMI patients admitted to a Detroit metropolitan hospital between October 1989 and January 1990. Variables evaluated included demographic and medical history factors, psychological characteristics of somatic and emotional awareness, and type A behavior. The mean prehospital delay time was 9.0 +/- 10.8 hours (median, 5.0 hours; range, 0.25-62.0 hours). Delay time was not significantly associated with demographic or medical history categories or with type A behavior. Of study variables that can be identified prior to evolution of an AMI, somatic and emotional awareness were the only factors significantly predictive of delay time. Patients who were more capable of identifying inner experiences of emotions and/or bodily sensations sought treatment significantly earlier than patients with low emotional or somatic awareness (low emotional awareness median delay, 12.8 hours; high emotional awareness median delay, 3.8 hours; low somatic awareness median delay, 7 hours; high somatic awareness median delay, 4 hours).Variations in sensitivity to bodily sensations and emotions appear to play an important role in treatment seeking and thus potentially in treatment outcome for AMI patients. Assessment of these characteristics in patients with coronary risk factors could allow early identification of persons at risk of excessive delay in responding to symptoms of AMI.
Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis.
Authors: H W Murray, J Hariprashad
Journal: The Journal of Experimental Medicine (1995)

When administered at or near the initiation of experimental intracellular infection caused by Leishmania major, Toxoplasma gondii, or Cryptococcus neoformans, treatment with the immuno-regulatory cytokine interleukin 12 (IL-12), induces protective antimicrobial activity. In contrast, once infections are established, IL-12 exerts considerably less or no effect in the face of a suppressive Th2 cell-associated response (L. major) or rapidly progressive fatal infection (T. gondii). To test the efficacy of IL-12 in an established intracellular protozoal infection but under quite different immunologic conditions (Th1 cell response, acquired resistance), L. donovani-infected BALB/c mice were treated starting 2 wk after challenge coincident with the onset of the Th1 cell response. In this environment, 7 d of IL-12 treatment reduced liver parasite burdens by 47%, an effect comparable to that induced by exogenous interferon (IFN) gamma. The in vivo mechanism responsive to IL-12 was complex, and required both CD4+ and CD8+ T cells as well as natural killer cells and the action of multiple endogenous antileishmanial cytokines (IFN-gamma, IL-2, tumor necrosis factor alpha). Early treatment with IL-12 before the expression of the Th1 cell response was also effective and induced an accelerated, near-cure response via an IFN-gamma-dependent mechanism. These results extend the antimicrobial-inducing capacity of IL-12 beyond prophylaxis by indicating that IL-12 can exert clear-cut therapeutic activity in an established intracellular infection.
The Challenge of Quality Improvement in Surgical Care
Authors: David R. Urbach
Journal: JAMA Surgery (2015)

39. Pastor C, Artinyan A, VarmaMG, Kim E, Gibbs L, Garcia-Aguilar J. An increase in compliance with the Surgical Care Improvement Project measures does not prevent surgical site infection in colorectal surgery. Dis Colon Rectum. 2010;53(1): 24-30. 40. Helfrich CD, Damschroder LJ, Hagedorn HJ, et al. A critical synthesis of literature on the Promoting Action on Research Implementation in Health Services (PARIHS) framework. Implement Sci. 2010;5:82.
Target specific systemic delivery of TGF-β siRNA/(PEI-SS)-g-HA complex for the treatment of liver cirrhosis
Authors: Kitae Park, Sung Woo Hong, Wonhee Hur, Min-Young Lee, Jeong-A. Yang, Sung Woo Kim, Seung Kew Yoon, Sei Kwang Hahn
Journal: Biomaterials (2011)
The Current Status of Nuclear Medicine
Authors: Henry N. Wagner
Journal: JAMA (1963)

THE INVENTION of the compound microscope in 1830 was a milestone of special significance in medical history. Since that time improvements in medical diagnosis can be closely correlated with the invention of instruments, some of which have become practically indispensable. The field of ophthalmology may be used as an example. A few years after the invention of the ophthalmoscope by Helmholtz in 1851, Dr. Elkanah Williams of Cincinnati introduced this instrument into the United States. Shortly thereafter he limited his practice exclusively to ophthalmology and otology. The pattern of development of ophthalmology, the first of the medical specialities, has been duplicated many times in other special areas of medicine. First, new instruments are invented that facilitate medical diagnosis. In developing accuracy and skill in their use, physicians find that less and less of their time is spent in the practice of general medicine. Eventually they limit their practice to
THE ANTIGENIC COMPLEX OF STREPTOCOCCUS HÆMOLYTICUS
Authors: Rebecca C. Lancefield
Journal: The Journal of Experimental Medicine (1928)

1. The chemical and immunological characteristics of the species-specific substance (C) of Streptococcus haemolyticus are considered. (a) It seems to be a carbohydrate because considerably purified preparations of C resisted prolonged tryptic and peptic digestion and were negative for the ordinary protein color tests but gave positive Molisch reactions to the limit of the precipitin titer. One such "purified" lot, however, had 4.2 per cent nitrogen and only 28 per cent reducing sugars on hydrolysis. Whether the nitrogen was due to impurities or was combined in the C substance itself, as is true of the Type I pneumococcus specific polysaccharide, cannot be stated without more material. (b) The C substance forms precipitates with antibacterial sera prepared against heterologous, as well as against homologous hemolytic streptococci. These precipitates are typical discs like those formed by type-specific carbohydrates of other species of bacteria. C does not precipitate antinucleoprotein sera. (c) While there is only slight direct evidence that the C substance is not antigenic, there is considerable indirect proof that this is the case. It probably is a haptene in the sense of Landsteiner. 2. A discussion is included of the chemical and immunological relationships of all the serologically active substances so far identified in extracts of the hemolytic streptococcus.
NIDDM and Prevalence of Nasal <i>Staphylococcus aureus</i> Colonization: San Luis Valley Diabetes Study
Authors: Edward J Boyko, Benjamin A Lipsky, Rodney Sandoval, Ellen M Keane, Janet S Monahan, Roger E Pecoraro, Richard F Hamman
Journal: Diabetes Care (1989)

Previous studies of hospitalized and ambulatory patients have found a higher prevalence of Staphylococcus aureus nasal colonization in diabetic than nondiabetic subjects. We examined this association in a geographically based study among 551 residents of the San Luis Valley of Colorado and found no statistically significant increase in the relative risk of nasal S. aureus colonization in 188 non-insulin-dependent diabetic (NIDDM) versus 363 nondiabetic subjects (relative risk 1.3, 95% confidence limits 0.9–1.8). Adjustment for confounding by age, sex, ethnicity, county of residence, and frequency of hospitalizations or physician visits in the previous year did not affect the results. Among the diabetic subjects, S. aureus colonization was not associated with type of treatment for diabetes, level of glucose control, clinical duration of diabetes, or frequency of hospitalizations or physician visits in the previous year. In this population-based study, diabetes mellitus did not increase S. aureus nasal colonization, suggesting that factors other than diabetes mellitus may have caused the higher colonization rate found in previous clinic-based studies.
The Knight of Faith
Authors: Matthew D.S. Klein
Journal: Annals of Internal Medicine (1998)

On Being a Doctor15 June 1998The Knight of FaithMatthew D.S. Klein, MDMatthew D.S. Klein, MDBridgton, ME 04009Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-12_Part_1-199806150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “The Knights of the Infinite Resignation are easily recognized: their gait is gliding and assured. Those on the other hand who carry the jewel of Faith are likely to be delusive, because their outward appearance bears a striking resemblance to … Philistinism.”Soren Kierkegaard, Fear and TremblingA team of doctors was circled around a bed in the intensive care unit of the county hospital. The boy before them had just at that moment raised his head and disgorged a stream of blood into the air. It fell with a slap onto his white sheets and dripped off the side ... Author, Article, and Disclosure InformationAuthors: Matthew D.S. Klein, MDAffiliations: Bridgton, ME 04009Corresponding Author: Matthew D.S. Klein, MD, 103 South High Street, Building B, Bridgton, ME 04009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1998Volume 128, Issue 12_Part_1Page: 1040-1042KeywordsBloodBlood transfusionEmotionsFearHeartHemorrhageIntensive care unitsSurgeryUlcersVentilators ePublished: 15 August 2000 Issue Published: 15 June 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Spindle Cell Sarcoma Degeneration of Giant Cell Tumor of the Knee, Imaged With F-18 FDG PET-CT and Tc-99m MDP Bone Scan
Authors: William Makis, Marc Hickeson
Journal: Clinical Nuclear Medicine (2010)

Giant cell tumor is a benign but aggressive bone tumor that occurs in young adults ages 20 to 40, accounts for 20% of benign bone tumors, occurs mostly in the metaphyso-epiphyseal region of long bones, and is characterized by the presence of multinucleated giant cells. The risk of malignant degeneration is approximately 10%. We present a 46-year-old man with a history of recurrent giant cell tumor of the left tibial plateau, treated with total knee prosthesis in 2006. In 2008, he presented with knee pain, and a Tc-99m MDP bone scan showed increased uptake surrounding the knee prosthesis. A F-18 fluoro-deoxy-glucose positron emission tomography-computed tomography (FDG PET-CT) scan showed intense uptake in the soft tissue surrounding the distal left femur, as well as other skeletal and soft tissue sites of abnormal FDG uptake. The biopsy of the distal left femur revealed the presence of spindle cell sarcoma.
License in Germany.
Authors: Gustavus M. Blech
Journal: JAMA (1898)

<i>Detroit, Mich</i>., Dec. 20, 1897. <h3>To the Editor:</h3> —Dr. B. Becker's friendly corrections and suggestions concerning the licensing of physicians in Germany are to the point, but in some instances incorrect. While the subject is too unimportant to consume much of your space, once begun, I believe in finishing anything correctly. An American graduate in medicine, in order to matriculate at a German university needs possess no further documents than his diploma and passport. Whether or not an A.B. or A.M. degree of this country would be considered an equivalent by the German authorities of a<i>testimonium maturitatis</i>I am not prepared to say. Any physician desiring to leave this country for the sake of engaging in the practice of medicine in Germany where, by the way, there is absolutely no demand for a foreign physician, can get the necessary particulars by addressing either Seine Magnificenz p. t. Decanus der
Feeling Good and Doing Better: Ethics and Nontherapeutic Drug Use
Authors: Louis Lasagna
Journal: JAMA (1985)

Physicians should not be put off by the "pop" title of this book because it deals with an important issue— whether the public should be freer to use drugs for pleasure or to improve their performance over "the norm." The medical model has operated on the notion that drugs are fine for curing disease or alleviating the symptoms of illness but that bringing a person's functioning beyond medically defined levels of normalcy is not acceptable. Taking drugs for "recreational purposes" has generally been considered immoral, illegal, or both. Our society is, to be sure, magnificently inconsistent about these matters. We tolerate alcohol and cigarettes but not marijuana. Athletes can train to the point where their bodies and souls scream for surcease, sniff oxygen, and consume any outlandish regimen of food, vitamins, and minerals but can be disqualified even for taking antiasthma remedies, let alone anabolic steroids or amphetamines. What is
Successful Cardiac Massage, Open and Closed
Authors: Donald H. Dembo
Journal: JAMA (1967)

To the Editor:—  Shocket and Rosenblum present a most provocative account of successful open cardiac massage following unsuccessful closed-chest cardiopulmonary resuscitation inThe Journal( 200 : 333, 1967). They reported that 75 minutes of closed-chest massage sustained but failed to resuscitate a 32-year-old patient. This report among others demonstrates the need for high standards in closed-chest cardiopulmonary resuscitation. The authors report a common cause of failure in closed-chest cardiopulmonary resuscitation, that of inadequate attention to detail. Success requires prompt and adequately performed emergency measures ( for sustaining life ) and specific therapy for resuscitation, per se. The National Research Council has approved the high standards of both emergency and definitive therapy outlined by the American Heart Association's Committee on Closed-Chest Cardiopulmonary Resuscitation ( 198 :372, 1966).  Repeated administration of epinephrine at intervals of five minutes is strikingly effective in increasing perfusion pressure and, more importantly, the vigor of ventricular fibrillatory activity. The latter is