tbuckley/cabot-search huggingface dataset:
Stones, Crohn's disease and Meckel's diverticulum.
Authors: I C Harvey, H J White
Journal: BMJ (1976)

Stones, Crohn's disease, and Meckel's diverticulum Multiple faceted radio-opaque stones within the abdomen are usually situated in the gall bladder, and the incidence of gall stones is increased in patients with Crohn's disease.' Enteroliths may rarely be found in a Meckel's diverticulum,2 and there is an increased-incidence of Meckel's diverticulum in Crohn's disease.3Stones in a Meckel's diverticulum associated with Crohn's disease have not been reported, but we describe such a case. Case reportA 62-year-old man presented on 19 December 1974 with a two-week history of intermittent central abdominal pain radiating to the right hypochondrium.His only other symptoms were slight constipation and nocturia.He had a tender mobile mass in the right iliac fossa, but, apart from an enlarged prostate, no other abnormality was found.In view of this mass, a barium enema was performed on 23 December.Initial screening disclosed several flat, triangular, laminated stones in the right side of the abdomen, with two further stones in the left iliac fossa.The calibre and haustral pattern of the large bowel were normal throughout.The terminal ileum was abnormal, showing some dilatation with loss of mucosal pattern (see figure).. . ,~~~. .
Deceleration-dependent left bundle branch block: a spectrum of bundle branch conduction delay.
Authors: C Fisch, W M Miles
Journal: Circulation (1982)

DECELERATION ABERRANCY/Fisch and Miles management of the interaction between amiodarone on warfarin, and adjustment of the warfarin dose is a better solution.We recommend that the maintenance dose of warfarin be halved when amiodarone therapy is begun, irrespective of the dose of amiodarone pre- sCribed.
Training in Clinical Pharmacology and Experimental Therapeutics
Authors: John H. Moyer
Journal: JAMA (1967)

An unfortunate academic perspective concerning L therapeutics has been carried over from the past into the present. Many of our outstanding medical schools maintain the attitude that pathophysiology of medical diseases and the art and science of diagnosis are all-important in medical education, and that "any fool can treat." This may have been appropriate 40 years ago, when effective therapeutic agents were indeed few in number, but the concept is hardly applicable today. With the development of new and potent agents, the administration of these agents must become as specific and precise as the surgeon's knife, if maximum therapeutic benefit is to be obtained. An even more unfortunate corollary is the attitude of some who take great pride in considering themselves "therapeutic nihilists." Among these are a number of academicians who, by virtue of their position, have great influence on their students. As a result, many of our newly graduated
Cyclosporin A reduces CD4+CD25+ regulatory T-cell numbers in patients with atopic dermatitis
Authors: DirkJan Hijnen, Inge Haeck, Annemieke A. van Kraats, Evert Nijhuis, Marjolein S. de Bruin-Weller, Carla A.F.M. Bruijnzeel-Koomen, Edward F. Knol
Journal: Journal of Allergy and Clinical Immunology (2009)
Constitutive Expression of phVEGF <sub>165</sub> After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia
Authors: Iris Baumgartner, Ann Pieczek, Orit Manor, Richard Blair, Marianne Kearney, Kenneth Walsh, Jeffrey M. Isner
Journal: Circulation (1998)

Background —Preclinical studies have indicated that angiogenic growth factors can stimulate the development of collateral arteries, a concept called “therapeutic angiogenesis.” The objectives of this phase 1 clinical trial were (1) to document the safety and feasibility of intramuscular gene transfer by use of naked plasmid DNA encoding an endothelial cell mitogen and (2) to analyze potential therapeutic benefits in patients with critical limb ischemia. Methods and Results —Gene transfer was performed in 10 limbs of 9 patients with nonhealing ischemic ulcers (n=7/10) and/or rest pain (n=10/10) due to peripheral arterial disease. A total dose of 4000 μg of naked plasmid DNA encoding the 165-amino-acid isoform of human vascular endothelial growth factor (phVEGF 165 ) was injected directly into the muscles of the ischemic limb. Gene expression was documented by a transient increase in serum levels of VEGF monitored by ELISA. The ankle-brachial index improved significantly (0.33±0.05 to 0.48±0.03, P =.02); newly visible collateral blood vessels were directly documented by contrast angiography in 7 limbs; and magnetic resonance angiography showed qualitative evidence of improved distal flow in 8 limbs. Ischemic ulcers healed or markedly improved in 4 of 7 limbs, including successful limb salvage in 3 patients recommended for below-knee amputation. Tissue specimens obtained from an amputee 10 weeks after gene therapy showed foci of proliferating endothelial cells by immunohistochemistry. PCR and Southern blot analyses indicated persistence of small amounts of plasmid DNA. Complications were limited to transient lower-extremity edema in 6 patients, consistent with VEGF enhancement of vascular permeability. Conclusions —These findings may be cautiously interpreted to indicate that intramuscular injection of naked plasmid DNA achieves constitutive overexpression of VEGF sufficient to induce therapeutic angiogenesis in selected patients with critical limb ischemia.
Fifty Years in one Place.
Authors: D. Colvin
Journal: JAMA (1895)

Clyde, N. Y., April 30, 1895. <h3>To the Editor:</h3> —As you seem to desire, for some purpose, the photographs of the members of theAssociationI send mine with the announcement that the past winter completes my fifty-first year in practice—fifty years of married life, and fifty years residence in the same house. If any member of theAssociationcan boast of as many semi-centennial anniversaries of a like character, I would like to see his name in print. I also became a member of theAssociationat its meeting in New York City in 1864, the year of the election of its veteran founder, Dr. Davis, as President. Yours truly,
Late onset psychoses.
Authors: E Warren
Journal: BMJ (1972)

dialysis and non-dialysis group were com- parable for age and sex and whether the apparent differences in small numbers of patients was statistically significant.We studied the immediate effect of dialysis and found no significant difference in the peak acid output measured in the same 14 patients before and after dialysis,2 but on reviewing our data we find that the basal acid output was significantly reduced after dialysis (P<O.05).The peak acid output measures the parietal cell mass and perhaps its sensitivity to pentagastrin, but the changes in basal acid output, though less reproduceable, may reflect the changes in urea and electrolytes produced by dialysis.-Iam, etc.,
Atopic dermatitis management: comparing the treatment patterns of dermatologists in Japan, U.S.A. and U.K.
Authors: E.D. Baron, D. Barzilai, G. Johnston, M. Kawashima, M. Takigawa, H. Nakagawa, R.A.C. Graham-Brown, S.R. Stevens
Journal: British Journal of Dermatology (2002)

Summary Background The incidence of atopic dermatitis (AD) is increasing worldwide. No large‐scale study has previously compared the therapeutic management of this condition in different countries. Objectives The purpose of this study was to determine the treatment preferences of dermatologists in Japan, the U.S.A. and the U.K., and investigate their relationship with certain factors pertaining to the physician and his practice. Methods A questionnaire was sent to all registered members of dermatological societies in Japan, the U.S.A. and the U.K. Responses were collated and statistical analysis performed using χ2, Mantel–Haenszel and Breslow heterogeneity tests. Results Three thousand six hundred and eighty‐eight completed surveys were returned. U.S.A. and U.K. physicians were significantly more aggressive in prescribing systemic medications, such as steroids, antibiotics and immunosuppressants, compared with those in Japan. Japanese dermatologists also utilized topical steroids significantly less. The use of alternative remedies was highest in Japan. All three countries had a relatively high degree of optimism for topical immunosuppressants, but less so for other emerging therapies. Conclusions Both similarities and differences in the therapy of AD exist in the three countries studied. Factors related to the physician, patient population and culture may influence these observations.
Renal Disease in Hypertensive Blacks: MRFIT
Authors: David H. Stockwell
Journal: JAMA (1993)

<h3>To the Editor.</h3> —In their analysis of renal function data from the Multiple Risk Factor Intervention Trial (MRFIT), Walker et al<sup>1</sup>report that among all treated hypertensive patients and among those with controlled diastolic blood pressure (DBP, &lt;95 mm Hg), renal function improved in nonblack men, but declined in black men. We believe that these important conclusions should be treated cautiously. First, as the authors state, the study is limited by the inclusion of only a small number of blacks, and second, the study fails to account adequately for the possibility that major socioeconomic differences might confound what appear to be racial differences. Of the 5524 hypertensive men studied in MRFIT, only 463 were black. The importance of this limitation can be seen, for example, in the analysis of the influence of blood pressure control on renal function among blacks. Surprisingly, blacks whose blood pressure was controlled (DBP, &lt;95
Cardiovascular Magnetic Resonance Imaging for Valvular Heart Disease
Authors: Peter J. Cawley, Jeffrey H. Maki, Catherine M. Otto
Journal: Circulation (2009)

the last half century, clinicians have employed several means to advance our knowledge of the causes and consequences of valvular heart disease.Invasive cardiac catheterization provided valuable information about hemodynamics, 2-dimensional (2D) echocardiography (echo) allowed direct visualization of the valvular apparatus and cardiac chambers, and Doppler echocardiography afforded a noninvasive tool for assessing hemodynamics and disease severity.Echocardiography is now the standard tool for initial assessment and longitudinal evaluation of patients with valvular heart disease; however, echocardiography is limited in patients with poor acoustic windows and may be more operator dependent than other modalities, particularly for quantitation of disease severity.In the last 20 years, cardiovascular magnetic resonance (CMR) has emerged as an alternative noninvasive modality without ionizing radiation that is applicable to patients with valvular heart disease.CMR provides images of valve anatomy and allows quantitative evaluation of stenosis and regurgitation.CMR can also discern the consequences of the valvular lesion, including the effects of ventricular volume or pressure overload and alterations in systolic function.The purpose of the present review is to summarize the general principles of CMR and validate CMR as a tool for evaluation of valvular heart disease.
Potential adipokine involvement in systemic sclerosis
Authors: K. Frommer, M. Vasile, T. Schmeiser, O. Distler, S. Gay, V. Riccieri, A. Gunther, E. Roeb, U. Muller-Ladner, E. Neumann
Journal: Annals of the Rheumatic Diseases (2010)

Systemic sclerosis (SSc) is a chronic connective tissue disease characterised by excessive fibrosis resulting in its most noticeable symptom, the hardened skin. SSc also affects organs including the gastrointestinal (GI) tract, the vascular system, the lungs and the joints. We could previously show that profibrotic cytokines and infiltration of CD4 T lymphocytes are increased in the gastric wall (GW) of SSc patients. In rheumatoid arthritis (RA) we found that certain adipokines have immunomodulatory functions. We therefore analysed localisation of …
What Do Women Want? Comfy Shoes—Sometimes-Reply
Authors: Bernadine Z. Paulshock
Journal: JAMA (1993)

<h3>In Reply.</h3> —I certainly agree with Dr Balkin that the design of men's shoes has it all over women's for comfort and preservation of healthy feet. Men are always considered fashionably shod in shoes with roomy toes and low heels and women are not. I see signs of improvement in this, but total reform? Not in the foreseeable future. Most women prefer low heels, are more comfortable in flat shoes that do not have pointy toes, and wear them more frequently than they have in previous decades, but not yet, if ever, all of the time. When a woman is inaugurated president of the American Medical Association or of the United States, she will be not be wearing flat shoes with her inauguration outfit. I personally hope that along with an increased frequency of the appropriateness (fashionableness?) of low heels and roomier shoes—yes, more sensible shoes—also comes a trend to
Transcutaneous Oxygen Pressure Measurements on the Buttocks During Exercise to Detect Proximal Arterial Ischemia
Authors: Pierre Abraham, Jean Picquet, Bruno Vielle, Dominique Sigaudo-Roussel, Francine Paisant-Thouveny, Bernard Enon, Jean-Louis Saumet
Journal: Circulation (2003)

We sought to identify whether transcutaneous oxygen tension (tcPo2) measurements could be used to noninvasively detect lesions in the arterial network supplying blood flow to the hypogastric circulation.A study was undertaken in vascular patients with suspected (PC, n=43) and not with suspected (NPC, n=34) proximal ischemia. TcPo2 was measured on both buttocks and with a chest reference electrode. Arteriography on the right or left side was positive for stenoses (> or =75%) or occlusion of one or more of the following arteries: the aorta, the common iliac arteries, or the internal iliac arteries. The arteriography was compared with the resting tcPo2 values (REST) and with the minimal value (MIN) and maximal change from rest normalized to eventual chest changes (DROP) recorded during or after a treadmill test. REST, MIN, and DROP were, respectively, as follows in positive versus negative arteriograms (mean+/-SD; in mm Hg): 80.2+/-10.9 versus 78.6+/-11.5 (P>0.05), 55.2+/-20.0 versus 69.9+/-15.8 (P<0.001), and -31.8+/-17.6 versus -9.5+/-6.4 (P<0.0001) in PC and 78.9+/-14.0 versus 80.5+/-14.3 (P>0.05), 64.4+/-21.0 versus 75.1+/-14.6 (P<0.02), and -24.1+/-13.5 versus -8.7+/-4.8 (P<0.0001) in NPC. In PC and NPC respectively, with a cutoff point of -16 and -15 mm Hg, DROP showed, respectively, 83%/82% and 79%/86% sensitivity/specificity in the diagnosis of positive arteriograms.Proximal ischemia is a frequent finding in vascular patients. TcPo2 measurement on the buttocks during exercise is a sensitive and specific indicator for lesions in the arterial tree toward the hypogastric circulation. Potentially it could objectively assess the response to endovascular or surgical approaches to iliac lesions.
The community's response to mentally ill people
Authors: S. Sussman
Journal: BMJ (1997)

All societies have struggled with the impact of mental illness, and rejection and avoidance of mentally disabled people are common. Even when the mad have been accorded a place of honour, as in cultures that believe mentally ill people have been touched by the Great Spirit, they have remained outside the group and have been feared. Today this fear continues to obstruct moves towards caring more humanely for mentally ill people in the community. Many of those fears are unfounded and others may be allayed by sensible policy making.

Modern day psychiatry is empirically driven and biochemically oriented. After 400 years of development and reform many would say that, with all their flaws, psychiatric institutions provide relief and treatment to their patients. This judgment contrasts sharply with the anachronistic brouhaha of civil libertarians and the “consumer-survivor movement.” Community care …
CONGENITAL ECTODERMAL DEFECT WITH AMASTIA
Authors: Raymond Allen Osbourn
Journal: JAMA (1952)

Congenital ectodermal defect is a rare syndrome characterized by hypotrichosis, absence of sweat glands, absence of sebaceous glands, adontia or hypodontia, a characteristic facies, and, occasionally, absence of the mammary glands. About 80 such cases have been reported, but only 4 of these (all male) have had absence of the breasts and nipples.<sup>1</sup>The purpose of this report is to record a case of this variety. A brief consideration of the clinical appearance of patients with ectodermal defect (Fig. 1) reveals a great similarity in their appearance. The skin is thin, dry, and glossy, and the facies is somewhat suggestive of congenital syphilis. Frontal bossing is prominent, the supraorbital ridges are high and wide, the nasal bridge depressed, the lips thick and protruding, the teeth absent or deficient, and the nails normal or dystrophic. Cases have been reported of absence of mammary glands, chiefly in females, unassociated with
Case 22-1974
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Homayoun Kazemi, Gerald Nash
Journal: New England Journal of Medicine (1974)

Presentation of CaseA 77-year-old man was admitted to the hospital because of dyspnea.He was well until three years previously, when there was the onset of mild hoarseness. Fourteen months before entry exertional dyspnea developed, and on admission to another hospital a right pleural effusion was found. A bronchoscopic examination, a scalene-lymph-node biopsy and an open pleural biopsy were nondiagnostic. The pleural effusion cleared, and the patient felt well except for a persistent cough. One year before admission a bladder infection was found; nitrofurantoin was prescribed, one tablet daily on six days per week, and was taken until admission. . . .
Abstract 838: Distinct effects of S6K homologues on breast cancer cell survival.
Authors: Savitha Sridharan, Alakananda Basu
Journal: Cancer Research (2013)

Abstract The 40S ribosomal protein S6 kinase (S6K) acts downstream of the mammalian target of rapamycin (mTOR), which is an important target for cancer therapy. mTOR inhibitors are, however, of limited success, partly due to the activation of Akt caused by persistent inhibition of mTOR/p70 S6 kinase or S6K1 via a negative feedback loop. S6K exists as two homologs, S6K1 and S6K2. While both homologs are overexpressed in breast cancer, little is known about the function of S6K2. The objective of the present study is to determine whether S6K homologs perform redundant or distinct functions with respect to Akt activation and breast cancer cell survival. Silencing of S6K1 inhibited whereas knockdown of S6K2 potentiated cell death by various apoptotic stimuli, including tumor necrosis factor-alpha (TNF) and TNF-Related Apoptosis Inducing Ligand (TRAIL). In contrast to S6K1, depletion of S6K2 decreased Akt phosphorylation in MCF-7 and T47D cells. Ectopic expression of constitutively-active Akt in MCF-7 cells restored cell survival in S6K2-depleted cells. We have previously shown that activation of Akt induces downregulation of Bid via p53. Knockdown of S6K2 caused an increase in p53 and silencing of Bid blunted the ability of S6K2 deficiency to enhance TNF-induced apoptosis. Thus, our study demonstrates for the first time that the two homologs of S6K have distinct effects on Akt activation and cell survival and that S6K2 depletion enhanced cell death via the proapoptotic Bcl-2 family member Bid. Thus, targeting S6K2 may be an effective therapeutic strategy to treat cancers. (This work was supported by the grant CA71727 from the NCI). Citation Format: Savitha Sridharan, Alakananda Basu. Distinct effects of S6K homologues on breast cancer cell survival. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 838. doi:10.1158/1538-7445.AM2013-838
Mastery of Surgery
Authors: Daniel J. Kacey
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1006-45 Regression of Infarct-Related Coronary Lesions on Aggressive Lipid Lowering Treatment in Patients After Recovery from Acute Myocardial Infarction
Authors: Morimasa Takayama, Kazuo Munakata, Yoshifumi Tomita, Haruo Kaneko, Satohiro Kunmi, Hiroyuki Yokoyama, Yoshiki Kusama, Teruo Takano, Hirokazu Hayakawa
Journal: Journal of the American College of Cardiology (1995)
The Scintigraphic Visualization of a Lingual Thyroid After Excision of Associated Ectopic Thyroid Tissue
Authors: SYDNEY HEYMAN
Journal: Clinical Nuclear Medicine (1979)

The scintigraphic findings in a 2-year-old boy with both a lingual thyroid and ectopic thyroid tissue in the neck are presented. One day following excision of the neck mass, no functioning thyroid tissue was seen. However, one month later, the lingual gland was well visualized. The possible reason for this is discussed.