tbuckley/cabot-search huggingface dataset:
CURRENT THERAPY OF SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Edmund L. Dubois
Journal: JAMA (1960)

The current clinical concept of systemic lupus erythematosus is reviewed on the basis of a 10-year study of 400 patients treated with rest, salicylates, antimalarials, and corticosteroids. Particular attention was given to the therapeutic value and side-effects of the corticosteroids. Fifty patients received dexamethasone for periods up to 15 months. The maximum dose was 24 mg. per day for three weeks and the average maintenance dose was 2.7 mg. per day. Clinical improvement closely paralleled that obtained by other corticoids. Side-effects included edema (28%), hirsutism (28%), and insomnia (8%), and serial upper gastrointestinal roentgenograms performed in 28 patients revealed peptic ulcers in 5. There was a disappearance of all the clinical and laboratory abnormalities produced by the disease with the exception of long-standing renal involvement.
The Operated Stomach - Still a Precancerous Condition?
Authors: P. Hermanek, J.F. Riemann
Journal: Endoscopy (1982)

See also: LETTER TO THE EDITOREndoscopy 1984; 16(02): 81-81DOI: 10.1055/s-2007-1018540 See also: LETTER TO THE EDITOREndoscopy 1984; 16(02): 81-82DOI: 10.1055/s-2007-1018541
Prostate Stem Cell Antigen Is Overexpressed in Prostate Cancer Metastases
Authors: John S. Lam, Joyce Yamashiro, I. Peter Shintaku, Robert L. Vessella, Robert B. Jenkins, Steve Horvath, Jonathan W. Said, Robert E. Reiter
Journal: Clinical Cancer Research (2005)

Abstract Purpose: Prostate stem cell antigen (PSCA) is expressed by a majority of prostate cancers and is a promising therapeutic target. PSCA protein and mRNA expression was examined in prostate cancer bone, lymph node, and visceral metastases to assess the potential of PSCA as an immunotherapeutic target in advanced prostate cancer. Experimental Design: Immunohistochemical analysis of PSCA protein expression and quantitative mRNA expression analysis of PSCA was done on clinical specimens of prostate cancer bone, lymph node, and visceral metastases. PSCA protein and mRNA expression levels were quantified and compared between available matched pairs of bone and lymph node or visceral metastases. Results: Bone metastases stained with higher intensity of PSCA compared with lymph node or liver metastases in seven of eight (87.5%) matched pairs (P = 0.035). PSCA mRNA expression was equal or greater than that of LAPC-9, a PSCA expressing xenograft, in 12 of 24 (50%) cases of prostate cancer metastases and was significantly correlated with PSCA protein expression (σ = 0.84, P = 0.0019). Overall, PSCA protein expression was detected in 41 of 47 (87.2%), four of six (66.7%), and two of three (66.7%) cases of bone, lymph node, and liver metastases, respectively. Mean PSCA staining intensity was significantly higher in prostate cancer bone metastases compared with lymph node metastases (2.0 ± 0.02 versus 0.83 ± 0.31, P = 0.014). Conclusions: Prostate cancer metastases express PSCA. However, greater PSCA staining intensity and level of PSCA mRNA expression was associated with bone metastases compared with lymph node metastases. This study suggests that PSCA is a promising tumor marker and potential therapeutic target for patients with metastatic prostate cancer.
Uptake of 99mTc-Diphosphonate in Soft Tissue in Sickle Cell Anemia
Authors: MICHAEL J. GELFAND, MELINDA K. PLANITZ
Journal: Clinical Nuclear Medicine (1977)

Concentration of 99mTc-etidronate tin complex was noted in the soft tissues of a patient with sickle cell anemia, in a distribution that suggested uptake in skeletal muscle.
FDG PET for Imaging Pericardial Manifestations of Hodgkin Lymphoma
Authors: Inga Buchmann, Hannes Wandt, Andreas Wahl, Sven Norbert Reske
Journal: Clinical Nuclear Medicine (2003)

A 61-year-old man with Hodgkin lymphoma (mixed type), with lymph node manifestations and extranodal and bone marrow involvement in both supra- and infradiaphragmatic locations (stage 4), had dyspnea and tachycardia on echocardiography. There were pleural and pericardial effusions and thickening of the epicardium and pericardium. These findings and computed tomographic findings were suspicious for manifestations of Hodgkin lymphoma. The pericardial findings were demonstrated on F-18 fluorodeoxyglucose positron emission tomographic imaging.
Direct ovarian effects and safety aspects of GnRH agonists and antagonists
Authors: R. M. J. Janssens
Journal: Human Reproduction Update (2000)

In in-vitro fertilization programmes, gonadotrophin releasing hormone (GnRH) agonists are now routinely used in order to prevent the undesired pre-ovulatory spontaneous luteinizing hormone surge. The first publications are now appearing in which GnRH antagonists are used with the same purpose. More attention should be addressed to the safety aspects of these drugs. This review aims to summarize studies on direct ovarian effects of GnRH agonists and GnRH antagonists in non-primates and primates with respect to the functional and morphological aspects in-vitro as well as in-vivo. We conclude that there is a wide variety of functional and morphological effects of GnRH analogues on the ovary. The sometimes paradoxical effects indicate that a variety of factors may be involved in the various processes. Those factors are: (i) the type and dose of the analogue, (ii) the different regimens of administration, (iii) ovarian status at the time of exposure, (iv) ovarian cell types in in-vitro systems, (v) hormonal pre-treatment of these cultures, (vi) the type of hormonal stimulation added to the in-vitro culture, (vii) further methodological differences in the experiments and finally (viii) physiological variations in GnRH receptor abundance which depends on species and/or timing in the cycle. With the increasing number of patients using GnRH analogues in assisted reproduction treatments, there will be an increasing number of pregnancies exposed to these drugs. So far, there does not appear to be an increased risk of birth defects or pregnancy wastage in human pregnancies exposed to daily low-dose GnRH agonist therapy in the first weeks of gestation.
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver
Authors: Dennys E. Cintra, José R. Pauli, Eliana P. Araújo, Juliana C. Moraes, Cláudio T. de Souza, Marciane Milanski, Joseane Morari, Alessandra Gambero, Mário J. Saad, Licio A. Velloso
Journal: Journal of Hepatology (2008)
Early periportal sinusoidal fibrosis is an accurate marker of accelerated HCV recurrence after liver transplantation
Authors: Zoe Mariño, Laura Mensa, Gonzalo Crespo, Rosa Miquel, Miquel Bruguera, Sofía Pérez-del-Pulgar, Jaume Bosch, Xavier Forns, Miquel Navasa
Journal: Journal of Hepatology (2014)
Haemolytic Disease in One Dizygotic Twin
Authors: F. Stratton, F. A. Langley, U. Lister
Journal: BMJ (1945)

Absorption and ExcretionTo obtain some idea of the absorption and excretion of the drugs in man the blood concentrations were estimated at the end of the course of drug administration.For the purpose of comparison similar investigations were carried out in five patients who received similar dosages of sulphanilylguanidine (S.A.G.).The results are shown in Table III, from which it will be seen that the concentration of S.A.B. is roughly four times that of S.A.G. and that 20% of this is acetylated, as compared with 34% of S.A.G.With full dosage of S.A.A.B. the concentration is about 30%°O more than that of S.A.
CXCL13-Producing Follicular Helper T Cells in Human Breast Cancer
Authors: C. Gu-Trantien, E. Migliori, L. Buisseret, S. Garaud, J. Lodewyckx, H. Duvillier, C. Naveaux, D. Larsimont, K. Willard-Gallo
Journal: Annals of Oncology (2014)
IMPAIRED ENERGETICS AND HEART FAILURE: RATES OF ADENOSINE TRIPHOSPHATE TRANSFER THROUGH CREATINE KINASE PREDICT CLINICAL HEART FAILURE EVENTS AND DEATH
Authors: Gurusher S. Panjrath, Paul Bottomley, Shenghan Lai, Glenn A. Hirsch, Wu Katherine, Samer S. Najjar, Gary Gerstenblith, Robert G. Weiss
Journal: Journal of the American College of Cardiology (2013)
Fallacies or analyses?
Authors: Jennifer Church
Journal: Behavioral and Brain Sciences (1995)

Abstract To demonstrate that a fallacy is committed, Block needs to convince us of two things: first, that the concept of phenomenal consciousness is distinct from that of access consciousness, and second, that it picks out a different property from that of access consciousness. I raise doubt about both of these claims, suggesting that the concept of a phenomenal property is the concept of a property to which we have a special sort of access.
Frontiers in Nephrology
Authors: Euan A. Ashley, Joshua M. Spin, Raymond Tabibiazar, Thomas Quertermous
Journal: Journal of the American Society of Nephrology (2007)

Atherosclerosis is a complex multicellular disease that is responsible for pathology in various organ systems. The understanding of its initiation and progression has been enhanced in recent years by the application of high-throughput genomic tools such as the microarray. Increasing in genomic coverage, such tools allow a view of the disease unaffected by previous conjecture as to the primary signal of interest. New statistical tools and pathway modeling techniques have established definitively for the first time the central role of inflammation in this process. This article reviews the genomic literature relating to atherosclerosis from cell culture, animal models, and human tissues. In this comparison of these differing approaches, the available data are synthesized to reach a new understanding of the complex interplay between vascular wall and immune system components.
The emergence of Lyme disease
Authors: Allen C. Steere, Jenifer Coburn, Lisa Glickstein
Journal: Journal of Clinical Investigation (2004)

Since its identification nearly 30 years ago, Lyme disease has continued to spread, and there have been increasing numbers of cases in the northeastern and north central US. The Lyme disease agent, Borrelia burgdorferi, causes infection by migration through tissues, adhesion to host cells, and evasion of immune clearance. Both innate and adaptive immune responses, especially macrophage- and antibody-mediated killing, are required for optimal control of the infection and spirochetal eradication. Ecological conditions favorable to the disease, and the challenge of prevention, predict that Lyme disease will be a continuing public health concern.
Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody.
Authors: K W McIntyre, G J Stepan, K D Kolinsky, W R Benjamin, J M Plocinski, K L Kaffka, C A Campen, R A Chizzonite, P L Kilian
Journal: The Journal of Experimental Medicine (1991)

Recombinant human interleukin 1 receptor antagonist (IL-1ra) and 35F5, a neutralizing monoclonal antibody (mAb) to the type I mouse IL-1 receptor, were examined for their ability to bind to IL-1 receptors (IL-1Rs) on various types of mouse cells and to block immune and inflammatory responses to IL-1 in vitro and in mice. IL-1ra competed for binding of 125I-IL-1 alpha to type I IL-1R present on EL-4 thymoma cells, 3T3 fibroblasts, hepatocytes, and Chinese hamster ovary cells expressing recombinant mouse type I IL-1R. The IC50 values for IL-1ra binding (ranging from 2 to 4 ng/ml) were similar to those of IL-1 alpha. In contrast, IL-1ra bound with very low affinity (IC50 values ranging from 10 to 200 micrograms/ml) to cells expressing type II IL-1R, i.e., 70Z/3 pre-B cell line and polymorphonuclear leukocytes (PMN) derived from bone marrow and acute inflammatory exudates. The mAb 35F5 bound specifically to type I IL-1R; no inhibition of 125I-IL-1 alpha binding to cells having type II IL-1R was observed with very high concentrations of antibody. While neither IL-1ra nor 35F5 had intrinsic activity in bioassays using T helper D10.G4.1 cells and mouse thymocytes, both agents blocked the ability of IL-1 to stimulate proliferation of these cells. The effects of IL-1ra and 35F5 on acute inflammatory responses in mice were also evaluated. IL-1ra and 35F5 blocked the local accumulation of PMN after intraperitoneal injection of rIL-1 alpha. The response to IL-1 was inhibited when IL-1ra or 35F5 was administered simultaneously with or before administration of IL-1. IL-1ra and 35F5 also blocked PMN accumulation after intraperitoneal injection of lipopolysaccharide or proteose peptone, suggesting IL-1 is important in mediating responses to these agents. In addition, IL-1ra and 35F5 significantly blocked the ability of IL-1 to stimulate egress of PMN from bone marrow, to induce a transient neutrophilia, and to elevate serum levels of hepatic acute phase proteins, IL-6, and corticosterone. Thus, IL-1ra and 35F5 competitively inhibit the binding of IL-1 to the IL-1R on certain cell types. These two IL-1 receptor antagonists act to inhibit biological responses induced by IL-1 and other inflammatory agents.
NHS England announces 10m plan to expand GP workforce
Authors: J. Wise
Journal: BMJ (2015)

NHS England has announced a £10m (€13m; $15m) plan to boost the number of GPs by increasing recruitment and retention and by encouraging doctors to return to general practice. The money is part of the £1bn additional investment in primary care infrastructure announced last week, which will mostly be used to upgrade general practice premises and equipment.

The plan to increase the number of GPs is part of the NHS’s recent Five Year Forward View , which set out a specific commitment to tackle workforce issues.1 The raft of initiatives has been developed in collaboration with Health Education England, the Royal College of General Practitioners, and the BMA. The aim is …
Decreased Bone Density and Thyroxine
Authors: Hunter Heath
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I write to comment on the article by Paul et al<sup>1</sup>reporting decreased femoral bone mineral density in women taking thyroxine in replacement or suppressive doses. The study by Paul et al is interesting and provocative, but is neither definitive nor consonant with other findings. For example, for thyroxine to cause decreased cortical bone density in the femur but no change in the more labile, preponderantly trabecular spinal bone mineral density seems unlikely. One must be uneasy about the inclusion of patients who had earlier suffered from Graves' disease, because of its known effect on bone density. With respect to those patients who had Hashimoto's thyroiditis, some of them might have had accompanying thyrotoxicosis. There are other elements in the data suggesting that this could have been a case-selection phenomenon rather than a specific effect of thyroxine; for example, Paul et al found no differences between
PERI-PROCEDURAL MYOCARDIAL INFARCTION WAS NOT ASSOCIATED WITH INCREASED RISK OF LONG-TERM CARDIAC MORTALITY AFTER CORONARY BIFURCATION STENTING: RESULTS FROM THE COBIS (CORONARY BIFURCATION STENTING) REGISTRY
Authors: Pil Sang Song, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Sang Hoon Lee, Myung-Ho Jeong, Hyo-Soo Kim, In-Whan Seong, Ju-Young Yang, Seung Woon Rha, Yangsoo Jang, Jung Han Yoon, Seung-Jea Tahk, Ki Bae Seung, Seung-Jung Park, Hyeon-Cheol Gwon
Journal: Journal of the American College of Cardiology (2011)
Sudden Infant Death Syndrome
Authors: Torgils Aaneland
Journal: JAMA (1974)

To the Editor.—  With reference to the article about the investigation of Dr. Naeye (228:555, 1974), and others ( Br Med J 1:341, 1974), the following factors seem to be present in 90% to 100% of cases in which cot deaths occur: (1) the baby is lying in a horizontal position in bed; (2) the baby is quietly asleep for some hours; (3) the death is a silent and unexpected event; (4) the baby is clothed and the covers are wrapped around the child; (5) the child is helpless and somewhat weak; and (6) a greater or lesser degree of interstitial edema is found in the lungs. 1   The most reasonable explanation of cot deaths, according to these premises, is, I think, that the baby is drowned in its own body fluid. This body fluid is more abundant in newborn babies than in adults, and highly mobile. Interstitial edema in the
RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1
Authors: Carmen Garnacho, Vladimir Shuvaev, Anu Thomas, Lindsay McKenna, Jing Sun, Michael Koval, Steven Albelda, Vladimir Muzykantov, Silvia Muro
Journal: Blood (2008)
Thromboembolic Complications with the Indwelling Balloon-Tipped Pulmonary Arterial Catheter
Authors: Daniel J. Goodman, Alan K. Rider, Margaret E. Billingham, John S. Schroeder
Journal: New England Journal of Medicine (1974)

FLOW-directed balloon-tipped catheters for monitoring circulatory hemodynamics in critically ill patients have become increasingly used.1 Reported complications include atrial and ventricular dysrhythmias,2 rupture of the balloon,2 clot formation on the catheter tip,2 knotting,3 hemoptysis,4 and perforation of the pulmonary artery.5 In the case described below thrombus formation on a damaged area of endothelium in the pulmonary artery was associated with the use of a balloon-tipped catheter; subsequent pulmonary emboli and infarction were probably related to this complication.Case ReportsCase 1. A 54 year-old woman was admitted to Stanford University Hospital because of severe progressive cardiac failure. Physical examination revealed . . .
Evaluation of the Response to Selective Internal Radiation Therapy in Patients With Hepatocellular Cancer According to Pretreatment 99mTc-MAA Uptake
Authors: Ozlem N. Kucuk, Cigdem Soydal, Mine Araz, Elgin Ozkan, Gulseren Aras
Journal: Clinical Nuclear Medicine (2013)

Aim The aim of the study was to evaluate if there is a prognostic importance of pretreatment 99mTc-MAA uptake of liver lesion of patients who received 90Y selective internal radiation therapy (SIRT) treatment for hepatocellular cancer (HCC) or not. Methods Nineteen patients (5 female and 14 male patients; mean age, 64.5 ± 14.7 years; range, 57–73 years) who received SIRT treatment in our department for HCC between June 2008 and May 2011 were included in the study. All the patients have undergone 99mTc-MAA scintigraphy within 2 weeks' period before treatment for evaluation of presence of extrahepatic uptake. Patients were evaluated according to their lesions' 99mTc-MAA uptake patterns. Response to the treatment, presence of progression after treatment, and progression-free survival of all the patients were calculated. Results Treatment has been administered on the right and left lobes of the liver in 18 and 1 patient, respectively. The mean treatment dose was estimated as 1.4 + 1.0 GBq. In the pretreatment 99mTc-MAA scintigraphy, liver lesions of 5 patients were hypoactive, and 14 patients were hyperactive. In the hypoactive group, whereas 2 patients (40%) were responders to treatment, 3 were nonresponders (60%). In the hyperactive group, 8 (58%) and 6 (42%) patients were responders and nonresponders, respectively (P = 0.51). Disease progression was seen in 4 (80%) and 8 patients (58%) in the hypoactive group and hyperactive groups, respectively (P = 0.36). Progression-free survival of the hypoactive group was calculated as 8 ± 4.3 months and of the hyperactive group 11 ± 4.7 months (P = 0.22). Conclusions Despite the small number of patients, this study revealed that there is no significance between tumor response and progression rates of patients who received SIRT for HCC with or without pretreatment 99mTc-MAA uptake in liver lesions. Selective internal radiation therapy could be safely performed in patients who have hypoactive lesions in 99m Tc-MAA scintigraphy.
TRICHOPHYTON TONSURANS RINGWORM: A CONTRIBUTION TO THE EPIDEMIOLOGY AND RARE CLINICAL MANIFESTATIONS.
Authors: FREDERICK REISS
Journal: British Journal of Dermatology (1954)

Journal Article TRICHOPHYTON TONSURANS RINGWORM: A CONTRIBUTION TO THE EPIDEMIOLOGY AND RARE CLINICAL MANIFESTATIONS. Get access FREDERICK REISS, M.D. FREDERICK REISS, M.D. Department of Dermatology and Syphilology, N.Y. University Post‐Graduate Medical School (Dr. Marion B. Sulzberger, Chairman), and the Service of Dermatology and Syphilology of Bellevue Hospital (Dr. Frank C. Combes, Chief of Service) Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 66, Issue 7, 1 July 1954, Pages 239–243, https://doi.org/10.1111/j.1365-2133.1954.tb12626.x Published: 01 July 1954
Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism
Authors: Giovanni Musso, Maurizio Cassader, Franco De Michieli, Floriano Rosina, Fabio Orlandi, Roberto Gambino
Journal: Hepatology (2012)

Nonalcoholic fatty liver disease (NAFLD) ranges from simple steatosis (SS) to nonalcoholic steatohepatitis (NASH). Though liver-related risk seems confined to NASH, it is currently unclear whether NASH has a higher risk of cardiovascular disease (CVD) and diabetes than SS as a result of the coexistence of obesity and other cardiometabolic confounders. Adipose tissue is an emerging modulator of liver disease in NAFLD and of cardiometabolic disease in the general population. We evaluated in SS and NASH (1) glucose homeostasis and cardiovascular risk profile and (2) the effect of adipose tissue dysfunction, assessed in fasting conditions and postprandially, on liver injury, glucose and lipoprotein metabolism, and markers of early atherosclerosis. Forty nonobese, nondiabetic, normolipidemic biopsy-proven NAFLD patients (20 with SS and 20 with NASH) and 40 healthy subjects, matched for overall/abdominal adiposity and metabolic syndrome, underwent an oral fat load test, with measurement of plasma triglyceride-rich lipoproteins, oxidized low-density lipoproteins, adipokines, and cytokeratin-18 fragments, and an oral glucose tolerance test with minimal model analysis to yield glucose homeostasis parameters. Circulating endothelial adhesion molecules were measured, and adipose tissue insulin resistance (adipose IR) index and visceral adiposity index were calculated. Despite similar fasting values, compared to SS, NASH showed a more atherogenic postprandial lipoprotein profile, an altered adipokine response (i.e., higher resistin increase and an adiponectin fall), and hepatocyte apoptosis activation after fat ingestion. Adipose IR index, endothelial adhesion molecules, and hepatic insulin resistance progressively increased across NAFLD stages. NASH, but not SS, showed an impaired pancreatic β-cell function. On multiple regression analysis, adipose IR index and postprandial adiponectin independently predicted liver histology and altered cardiometabolic parameters. Conclusion: Adipose tissue dysfunction, including a maladaptive adipokine response to fat ingestion, modulates liver injury and cardiometabolic risk in NAFLD.
A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.
Authors: M Takata, T Kurosaki
Journal: The Journal of Experimental Medicine (1996)

Defects in the gene encoding Bruton's tyrosine kinase (Btk) result in a disease called X-linked agammaglobulinemia, in which there is a profound decrease of mature B cells due to a block in B cell development. Recent studies have shown that Btk is tyrosine phosphorylated and activated upon B cell antigen receptor (BCR) stimulation. To elucidate the functions of this kinase, we examined BCR signaling of DT40 B cells deficient in Btk. Tyrosine phosphorylation of phospholipase C (PLC)-gamma 2 upon receptor stimulation was significantly reduced in the mutant cells, leading to the loss of both BCR-coupled phosphatidylinositol hydrolysis and calcium mobilization. Pleckstrin homology and Src-homology 2 domains of Btk were required for PLC-gamma 2 activation. Since Syk is also required for the BCR-induced PLC-gamma 2 activation, our findings indicate that PLC-gamma 2 activation is regulated by Btk and Syk through their concerted actions.