Herpes Simplex Encephalitis
Authors: JOHN K. MILLER
Journal: Annals of Internal Medicine (1966)

Article1 January 1966Herpes Simplex EncephalitisReport of 20 CasesJOHN K. MILLER, M.D., F.A.C.P., FREDERICK HESSER, M.D., F.A.C.P., VICTOR N. TOMPKINS, M.D.JOHN K. MILLER, M.D., F.A.C.P.Search for more papers by this author, FREDERICK HESSER, M.D., F.A.C.P.Search for more papers by this author, VICTOR N. TOMPKINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-92 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development of methods for cultivation of viruses and of improved antigens makes possible improved etiologic identification in some of the encephalitides. It is increasingly recognized that most cases of herpes encephalitis present a diffuse lesion. However, the signs and symptoms, including those adduced by the angiogram and the electroencephalogram, may also simulate a brain abscess or brain tumor.This series is comprised of 20 patients observed during a 10-year period. The first five cases were fatal. Herpes simplex virus was isolated from the brain of four patients. In the fifth case, characteristic type A intranuclear inclusions with peripheralization...References1. HAYMAKERSMITHVAN BOGAERTDE CHENAS WMGLC: Pathology of viral disease in man characterized by nuclear inclusions, in Viral Encephalitis, edited by FIELDS, W. S., BLATTNER, R. J. Charles C Thomas, Publisher, Springfield, Ill., 1958, p. 95. Google Scholar2. DRACHMANADAMS DARD: Herpes simplex and acute inclusion-body encephalitis. Arch. Neurol. (Chicago) 7: 45, 1962. CrossrefMedlineGoogle Scholar3. MEYERJOHNSONCRAWFORDDASCOMBROGERS HMRTIPHENG: Central nervous system syndromes of "viral" etiology. A study of 713 cases. Amer. J. Med. 29: 334, 1960. 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CROUSECORIELLBLANKSCOTT HVLLHTF: Cytochemical studies on the intranuclear inclusion of herpes simplex. J. Immun. 65: 119, 1950. MedlineGoogle Scholar11. LEBRUN J: Cellular localization of herpes simplex virus by means of fluorescent antibody. Virology 2: 496, 1956. CrossrefMedlineGoogle Scholar12. MORGANELLISONROSEMOORE CSAHMDH: Structure and development of viruses as observed in the electron microscope. I. Herpes simplex virus. J. Exp. Med. 100: 195, 1954. CrossrefMedlineGoogle Scholar13. ACKERMANKURTZ WWH: The relation of herpes virus to host cell mitochondria. J. Exp. Med. 96: 151, 1952. CrossrefMedlineGoogle Scholar14. SMITH KO: Relationship between the envelope and the infectivity of herpes simplex virus. Proc. Soc. Exp. Biol. Med. 115: 814, 1964. CrossrefMedlineGoogle Scholar15. HUNTCOMER BPEO: Herpetic meningo-encephalitis accompanying cutaneous herpes simplex. Amer. J. Med. 19: 814, 1955. CrossrefMedlineGoogle Scholar16. BRUNELLDODD PAK: Isolation of Herpesvirus hominum from the cerebrospinal fluid of a child with bacterial meningitis and gingivostomatitis. J. Pediat. 65: 53, 1964. CrossrefMedlineGoogle Scholar17. MACCALLUMPOTTEREDWARDS FOJMDH: Early diagnosis of herpes-simplex encephalitis by brain biopsy. Lancet 2: 332, 1964. CrossrefMedlineGoogle Scholar18. SMITHLENNETTEREAMES MGEHHR: Isolation of the virus of herpes simplex and the demonstration of intranuclear inclusions in a case of acute encephalitis. Amer. J. Path. 17: 55, 1941. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Albany, New YorkFrom the Division of Laboratories and Research, New York State Department of Health, and the Department of Neurology and the Institute of Preventive Medicine, Albany Medical College, Albany, N. Y.This paper was presented at the Second Fall Meeting of the American College of Physicians, October 30, 1964, Buffalo, N. Y.Requests for reprints should be addressed to John K. Miller, M.D., Division of Laboratories and Research, New York State Department of Health, Albany, N. Y. 12201. 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The clinical pictureEncephalitis in childrenErkrankungen des ZNS bei Virusinfektionen und nach SchutzimpfungenENCEPHALITISEncephalitis in the Newborn Pup due to a Canine HerpesvirusHerpes simplex encephalitis: Brain biopsy andtreatment with 5-iodo-2′-deoxyuridineHerpes encephalitisCase 52-1967Herpesvirus Infections of the Human Central Nervous SystemEncephalitis: A Variable Syndrome in Response to Viral InfectionNeurosurgical Experiences with Herpes Simplex EncephalitisMyocarditis in young military personnelHERPES-SIMPLEX PARTICLES IN ACUTE NECROTISING ENCEPHALITISPLUGGING A PERSISTENT DUCTUSACUTE NECROTISING ENCEPHALITISViral Diseases of the Nervous SystemAcute necrotizing encephalitis: a problem in diagnosis.Infectious diseases. Annual review of significant publications.Herpes simplex virus infections.The neuropathological aspects of acute encephalomyelitisHerpes Simplex Encephalitis Treated with Systemic 5-Iodo-2′deoxyuridineC. JANE BREEDEN, A.B., THOMAS C. HALL, M.D., F.A.C.P., H. RICHARD TYLER, M.D. 1 January 1966Volume 64, Issue 1Page: 92-103KeywordsBrainEncephalitisHerpes simplexLesionsLeukocytosisNeurologyPreventive medicineProteinsResearch laboratoriesSigns and symptoms Issue Published: 1 January 1966 PDF DownloadLoading ...