tbuckley/cabot-search huggingface dataset:
A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
Authors: Stephen H. Petersdorf, Kenneth J. Kopecky, Marilyn Slovak, Cheryl Willman, Thomas Nevill, Joseph Brandwein, Richard A. Larson, Harry P. Erba, Patrick J. Stiff, Robert K. Stuart, Roland B. Walter, Martin S. Tallman, Leif Stenke, Frederick R. Appelbaum
Journal: Blood (2013)
Diagnostic value of a glass fibre‐based histamine analysis for allergy testing in children
Authors: H. Nolte, K. Storm, P. O. Schiøtz
Journal: Allergy (1990)

The aim of this study was to compare the diagnostic value of common allergy tests with basophil histamine release in 124 children with symptoms of asthma. The patients were evaluated by case history, skin prick test, RAST‐analysis, and basophil histamine release using a glass fibre‐based histamine assay to 10 common inhalant allergens. The bronchia] provocation test was used as a reference of “true” IgE‐mediated asthma. To compare the various diagnostic parameters each absolute test value was classified into a scoring system. The concordance between the tests varied between 85–97%. In general, the best concordance was found between basophil histamine release and RAST. Sensitivity, specificity and predictive values were calculated on the basis of 104 bronchial provocation tests. It was found that histamine release was the best single analysis, followed by RAST and prick testing. The sensitivity of RAST and histamine release was very high (1.00) for pollen and house dust mites. Histamine release showed a predictive value between 0.91 and 1.00 for pollen and house dust mites, thus indicating the possibility of omitting the bronchial provocation test. In the dander group histamine release gave the best sensitivity (0.91), however at the expense of specificity (0.64), whereas RAST and skin prick test gave a specificity of 1.00. In the mould group histamine release also showed the best diagnostic value. The combination of skin testing with histamine release or RAST was of no additional diagnostic help. It is concluded that the glass fibre‐based histamine analysis, which makes routine histamine release testing possible, is a reliable diagnostic test in children.
Bromocriptine Therapy and Hyperprolactinemia
Authors: JOSÉ M. LÓPEZ
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 June 1987Bromocriptine Therapy and HyperprolactinemiaJOSÉ M. LÓPEZ, M.D., CARLOS B. FARDELLA, M.D.JOSÉ M. LÓPEZ, M.D.Search for more papers by this author, CARLOS B. FARDELLA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-6-909_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Bromocriptine, acting as a dopaminergic agonist, reduces the secretion of prolactin by the pituitary gland (1) and can also reduce the size of prolactinomas through a reduction of cytoplasmatic cell volume and tumoral cell population (2, 3). The usual dose of bromocriptine as a treatment for prolactinomas is from 5.0 to 10.0 mg/24 h. We report the case of a man with a prolactinoma who drastically reduced his serum prolactin level when treated with minimal doses of bromocriptine.A 55-year-old man was seen in December 1983 because of lack of libido, but was otherwise asymptomatic. His serum...References1. VANCEEVANSTHORNER MWM. Bromocriptine. Ann Intern Med. 1984;100:78-91. LinkGoogle Scholar2. INDALLKOVACSHORVATHTHORNER GKEM. Human prolactin-producing adenomas and bromocriptine: a histological, immunocytochemical, ultrastructural and morphometric study. J Clin Endocrinol Metab. 1982;55:1178-83. CrossrefMedlineGoogle Scholar3. GENUOZUMIOHTAITOKAJIWARAMORI MTMAHS. Necrotic changes in prolactinomas after long term administration of bromocriptine. J Clin Endocrinol Metab. 1984;59:463-70. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Universidad Católica de Chile Casilla 114-D; Santiago Chile PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReversal of hypogonadotropic hypogonadism with tamoxifen in a patient with hyperprolactinemia resistant to dopamine agonists 1 June 1987Volume 106, Issue 6Page: 909-910KeywordsDopaminergicsPituitary glandProlactin Issue Published: 1 June 1987 PDF downloadLoading ...
Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin.
Authors: H Shimokawa, L L Aarhus, P M Vanhoutte
Journal: Circulation Research (1987)

To test the ability of regenerated endothelium to evoke endothelium-dependent relaxations, male Yorkshire pigs underwent balloon endothelial denudation of the proximal left anterior descending coronary artery. Endothelium-dependent responses were examined in vitro, in rings of coronary segments taken from the denuded area or from the proximal left circumflex coronary artery. The experiments were performed 8 days or 4 weeks after the denudation. Endothelial regrowth was confirmed by histologic examination 8 days after the denudation and by demonstrating the presence of endothelium-dependent relaxations to bradykinin; at that time aggregating platelets evoked normal endothelium-dependent responses. However, 4 weeks after the denudation, the relaxations to aggregating platelets were markedly depressed although continuous endothelial lining was present, and the endothelium-dependent responses to bradykinin, adenosine diphosphate, the Ca2+-ionophore A23187, platelet activating factor, and thrombin were unaltered. Four weeks after denudation, endothelium-dependent relaxations to serotonin were depressed. Higher concentration of serotonin induced endothelium-dependent contractions in quiescent rings with regenerated endothelium, suggesting that regenerated endothelial cells may produce endothelium-derived constricting factor(s) and release less endothelium-derived relaxing factor(s) when exposed to the monoamine. The endothelium-dependent relaxation to serotonin was not reduced by the S2-serotonergic antagonist ketanserin but prevented by the combined S1- and S2-serotonergic blocker methiothepin. The platelet-induced relaxation was due to released serotonin and adenine nucleotides in control left circumflex coronary arteries, but in left anterior descending coronary artery with regenerated endothelium, it was due solely to the latter. The platelet-induced contractions were due to activation of receptors on the smooth muscle cells. Four weeks after denudation, regenerated endothelial cells were morphologically different from native cells; they were elongated and cuboidal, and the number of the cells had increased twofold. At this state, eccentric myointimal thickening was present in the previously denuded portion. These experiments indicate that the protective role of endothelial cells against the vasoconstriction induced by aggregating platelets is depressed in the chronic regenerated state. A lack of responsiveness to serotonin appears to be the cause for the endothelial dysfunction.
Dextran in the Prophylaxis of Deep-Vein Thrombosis
Authors: David Bergqvist
Journal: JAMA (1987)

To the Editor.—  The article by Oster et al1entitled A Cost-effectiveness Analysis of Prophylaxis Against Deep-Vein Thrombosis in Major Orthopedic Surgery is an important document that clearly shows that thromboprophylaxis saves both lives and health care money. It is of great importance for all of us to spread this knowledge.  The authors did not consider dextran because of  significant rate of complications and because it had not been found to be cost-effective. I would like to make three comments because I believe that this view is in part based on a misconception:   In most of the studies on the prophylaxis of thrombosis using dextran, dextran 70 has been used. Although the available evidence suggests that dextran 40 and dextran 70 are equally effective in preventing thromboembolism, the overwhelming majority of studies used dextran 70. I agree with the authors that there has been no placebo-controlled study
Competition within and between encrusting clonal invertebrates
Authors: Leo W. Buss
Journal: Trends in Ecology & Evolution (1990)

Colonies of encrusting marine invertebrates are tractable models for the study of competition, because of the relative ease with which observations can be made on the frequency and outcome of overgrowth interactions. Studies of intraspecific competition have found that competition is predicated upon a genetically controlled recognition event, which results in either fusion or rejection. Data are rapidly accumulating in two model systems showing that fusion is associated with somatic cell parasitism and that rejection is associated with overgrowth. Thus, encounters between conspecifics define a choice: to compete at the level of the cell lineage or to compete at the level of the colony. Fusion-rejection genes act to control the units (or targets) of selection.
Abstract 4337: Selection of DNA aptamers for an ovarian cancer cell line using high-throughput sequencing.
Authors: Rebecca J. Whelan, Arvinder Kapur, Mildred Felder, Jeff Nie, Manish S. Patankar
Journal: Cancer Research (2013)

Abstract The mucin, MUC16, facilitates metastasis and immuneprotection of ovarian tumors. Therefore, agents that effectively target MUC16 expressing ovarian cancer cells will be useful for diagnostic and therapeutic applications. Here, we have utilized the Cell-based Systematic Evolution of Ligands by Exponential Enrichment (cell-SELEX) approach to generate high affinity single-stranded DNA (ssDNA) aptamers as agents for detection and treatment of MUC16-positive ovarian tumors. An ssDNA aptamer library composed of ∼100 trillion sequences was subjected to ten iterative rounds of negative and positive selection using the MUC16-knockdown and MUC16-positive ovarian cancer cell line, OVCAR-3. Aptamers from each round were amplified by asymmetric PCR and subjected to high throughput NextGen sequencing. Eight ssDNA aptamers enriched through the selection process were identified by bioinformatics analysis and their selectivity and affinity for MUC16-positive cells was determined by flow cytometry. Two of these aptamers (Apt-1 and Apt-8) showed significant binding to the MUC16-positive OVCAR-3 with a Kd of 24 and 28 nM, respectively. In contrast, Apt-1 and Apt-8 only weakly recognized the MUC16-knockdown OVCAR-3 cells. M-Fold analysis indicated that Apt-1 and Apt-8 had defined secondary structures resulting from ordered base pairing of the ssDNA. The inclusion of NextGen sequencing techniques has therefore allowed rapid identification of theranostic aptamers from an exhaustive library of ssDNA sequences. This study provides a streamlined method for development of theranostic aptamers that can be used to recognize and target MUC16 expressing ovarian cancer cells. Citation Format: Rebecca J. Whelan, Arvinder Kapur, Mildred Felder, Jeff Nie, Manish S. Patankar. Selection of DNA aptamers for an ovarian cancer cell line using high-throughput sequencing. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4337. doi:10.1158/1538-7445.AM2013-4337
Pneumocystis Pneumonia: From Bench to Clinic
Authors: Henry Masur
Journal: Annals of Internal Medicine (1989)

Pneumocystis carinii is an intriguing organism found almost exclusively in the lungs. Very little is known about this organism's biologic or epidemiologic character. Over the past two decades, P. carinii has been recognized with increasing frequency as a cause of pneumonia in cancer patients, transplant recipients, and patients infected with the human immunodeficiency virus (HIV). With the increased number of cases of P. carinii pneumonia and a greater emphasis on studying this organism, sophisticated immunologic, metabolic, and molecular biologic tools have been applied to enhance diagnosis, therapy, and prevention. Immunologic studies have identified specific antigens of human P. carinii, resulting in the development of new diagnostic tests and more specific serologic data. Metabolic studies have allowed screening and identification of new therapeutic and preventive drugs. The development of nucleic acid libraries has allowed enzymes and other proteins to be elaborated in large quantities, facilitating a wide range of studies. These new techniques have changed and will continue to change the ways that pneumocystis pneumonia is diagnosed, treated, prevented, and understood.
THE TEACHING OF TROPICAL MEDICINE
Authors: ALFRED C. REED
Journal: JAMA (1926)

The curriculum in American medical schools is in process of change. It is not necessary to review all the causes for dissatisfaction with medical education or the problems now seeking solution. In this period of change, however, it is to be noted that less essential subjects are being dropped, and general subjects are receiving more attention at the expense of special subjects. To produce good general practitioners is an aim constantly more in mind. It is interesting that in this changing situation, with increasing emphasis on sound training in fundamentals, attention to tropical medicine is rapidly advancing. We find courses, departments and entire schools where a few years ago the entire subject was unknown. Is this a sound tendency, and why is it being pushed? <h3>WHAT IS TROPICAL MEDICINE?</h3> Strictly speaking, there are remarkably few strictly tropical diseases. Most of the great plagues of the tropics are more or less
Studies on the Use of Dioxyline Phosphate in the Treatment of Angina Pectoris
Authors: RALPH C. SCOTT, VINCENT J. SEIWERT, NOBLE O. FOWLER, JOHNSON MCGUIRE
Journal: Circulation (1952)

Dioxyline phosphate, on the basis of pharmacologic studies, appeared to be worthy of trial in the treatment of the anginal syndrome. The patients were studied during a control period and during alternate periods of placebo and dioxyline phosphate administration. Exercise tolerance tests were performed during each of the three periods of observation. The dosage of dioxyline phosphate was 800 mg. per day orally. Five of the 12 patients with angina experienced fewer pains while taking dioxyline phosphate than they did during either the control period or the period of placebo administration. The low incidence of serious side reactions was a conspicuous feature of the study.
Reporting Adverse Reactions to Herbal Ingestants
Authors: Walter H. Lewis
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Increasing numbers of persons are purchasing plant materials for use as foods from an expanding health-food-store industry. Unfortunately, the American public is unaware of the potential dangers of certain of these products; they assume and are accustomed to the fact that goods purchased from retail stores generally have been tested and approved for human use. However, many newly available plant products have not been tested; their effects on the body are not fully understood, or their effects simply are unknown to the majority of casual purchasers.<sup>1</sup> Recent examples illustrate the ignorance of the public of the hazards inherent in certain herbal preparations. Chamomile (<i>Chamaemelum nobile</i>and<i>Chamomilla recutita</i>), one of the most popular herbal teas made from flower heads, may cause either anaphylactic shock<sup>2</sup>or allergic rhinitis in atopic persons known to be sensitive to ragweed pollen. Moreover, senna leaves, flower buds, and young pods
Tap water iontophoresis in palmoplantar hyperhidrosis
Authors: S.N. SHRIVASTAVA, GURMOHAN SINGH
Journal: British Journal of Dermatology (1977)

Plain tap water iontophoresis as a method of treatment of idiopathic palmo-plantar hyperhidrosis was evaluated. In the present study, different strengths of current were used for varying periods of time and the treatment was given 6 days a week, until the patients became euhidrotic. Whereas previous workers have used the two electrodes in separate pans, we, in one study, placed them in the same pan of tap water, so that electrolysis occurred at the electrodes on which palms or soles were resting, the current passing through the medium. It was observed that, irrespective of the method used, euhidrosis of palms or soles were achieved. The time and the amount of current required to produce euhidrosis were significantly greater with the single pan technique (average 14-1 sittings in Group I) as compared to the separate pan method (average 7-09 sittings in group II) (t = 3-41, P less than 0.01). The euhidrosis persisted for between 6 and 8 months (average 6-26 months). In our study 90% of the patients treated developed anhidrosis on both the anode and cathode treated palms or soles. In 10% of the subjects, the effect was, however, greater on the anodal side.
Tumors of the Patella
Authors: David C. Dahlin
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I appreciate Dr. Johanson's calling attention to my error. I was referring to the type of bones that are formed by a growing epiphyseal line. I wish I knew the genesis of the chondromas that occur in para-articular tissues. I believe that the chondroma that we saw attached to the patella had that origin. I hope that if Dr. Johanson encounters an osteocartilaginous exostosis of the patella he will let me know of it.
Neck Injury to Women in Automobile Accidents
Authors: Howell E. Wiggins
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Their statement that "the proportion (about 75%) of women with symptoms 6 to 26 months after the accident was as great in the groups not involved or no longer involved in litigation as in the group with pending litigation" is at substantial variance with the experience of other authors. In a series of 313 cases of rearend collisions treated by me and my associates from 1958 to 1962, the recovery period averaged 6.1 weeks. Prolongation of convalescence occurred in practically every instance in those patients with preexisting degenerative disk disease or arthritic changes in the cervical spine. Disability benefits, apart from litigation, may well influence the recovery of industrial employees, and it would be of interest to know how many of the 15 patients remaining symptomatic 6 to 20 months after the accident, either without suit or status of the litigation being unknown, continued to receive disability benefits
Continuous Deep Sedation in End-of-Life Care: Disentangling Palliation From Physician-Assisted Death
Authors: Tito B. Carvalho, Mohamed Y. Rady, Joseph L. Verheijde, Jason Scott Robert
Journal: The American Journal of Bioethics (2011)

Chervenak and McCullough (2011) acknowledge the importance of including pregnant women in biomedical research as a means of ensuring that pregnant women and their fetuses have timely access to safe...
Intramuscular injections and gas gangrene.
Authors: S. D. Rubbo, J. F. Gardner
Journal: BMJ (1968)

long-stay patients are acquired.But this process is ultimately self-limiting, and we are now facing the more difficult problem of discharging the aged and the more severely disabled younger patients.It is easy enough to reduce the number of beds still further by adopting rigid criteria for the retention of such patients in hospital.Many of them would indeed be better off outside hospital, provided that they received sufficient support and aftercare.Can we honestly say that they will get it ?In the All Saints' Group we are attempt- ing to offer a wide and flexible range of facilities, including day care, hostel accom- modation, industrial rehabilitation, and domiciliary visiting by doctors, social workers, and nurses.We try to review patients regu- larly at every stage of their programme of resocialization inside and outside hospital.
USE OF NON-AMLODIPINE CALCIUM CHANNEL BLOCKERS IS NOT ASSOCIATED WITH OUTCOMES IN OLDER PATIENTS WITH HEART FAILURE AND PRESERVED EJECTION FRACTION
Authors: Ali Ahmed, Kanan Patel, Inmaculada Aban, Thomas Love, Alexander Lo, Stefan D. Anker, Richard Allman, Meredith Kilgore, Mihai Gheorghiade, Dalane Kitzman, Gregg Fonarow
Journal: Journal of the American College of Cardiology (2013)
6-Mercaptopurine in the Management of Inflammatory Bowel Disease: Short- and Long-Term Toxicity
Authors: Daniel H. Present, Stephen J. Meltzer, Michael P. Krumholz, Anita Wolke, Burton I. Korelitz
Journal: Annals of Internal Medicine (1989)

We assess toxicity related to 6-mercaptopurine in the treatment of inflammatory bowel disease by reporting our experience with 396 patients (120 patients with ulcerative colitis, 276 with Crohn disease) observed over 18 years. Follow-up data for a mean period of 60.3 months were obtained for 90% of the patients. Toxicity directly induced by 6-mercaptopurine included pancreatitis in 13 patients (3.3%), bone marrow depression in 8 (2%), allergic reactions in 8 (2%), and drug hepatitis in 1 (0.3%). These complications were reversible in all cases with no mortality. Most cases of marrow depression occurred earlier in our experience, when the initial drug doses used were higher. Infectious complications were seen in 29 patients (7.4%), of which 7 (1.8%) were severe, including one instance of herpes zoster encephalitis. All infections were reversible with no deaths. Twelve neoplasms (3.1%) were observed, but only 1 (0.3%), a diffuse histiocytic lymphoma of the brain, had a probable association with the use of 6-mercaptopurine. Our data, showing a low incidence of toxicity in 396 patients, coupled with the previously demonstrated efficacy of 6-mercaptopurine in the treatment of inflammatory bowel disease, indicate that the drug is a reasonable alternative in the management of patients with intractable inflammatory bowel disease.
TCT-406 Renal Artery Trauma Induced By Four Different Renal Denervation Systems. A Multi-Modality Intra-Arterial Imaging Study
Authors: Antonios Karanasos, Nicolas M. Van Mieghem, Martin W. Bergmann, Jurgen Ligthart, Christian H. Heeger, Felix Zijlstra, Evelyn Regar, Joost Daemen
Journal: Journal of the American College of Cardiology (2014)
US psychiatrist is fired from radio programme for not disclosing drug company ties
Authors: J. H. Tanne
Journal: BMJ (2008)

Frederick Goodwin, an eminent US psychiatrist, has been fired as host of a popular radio programme after Senator Charles Grassley revealed that the doctor had received $1.2m (£0.8m; €0.9m) in speaking fees and $100 000 in expenses from GlaxoSmithKline since 2000 ( Congressional Record , 19 Nov, pp S10641-4, “Payments to Radio Host”) 

The award winning programme, The Infinite Mind , was carried on two satellite channels of National Public Radio (NPR). It was produced by an independent company, Lichtenstein Creative Media, in Cambridge, Massachusetts. Dr Goodwin began hosting the programme in 1998.

NPR issued a statement saying that all programmes on the satellite channels were “expected to adhere to the same code of ethics and practices that apply to programs produced and distributed by NPR. It appears that The Infinite Mind was in direct violation of that code, and is being removed from the channel.”

Bill Lichtenstein, head of the media company, denied that his company knew Dr Goodwin had ties to industry that put its programme in breach of NPR’s code. He said, “We were aware that Dr Goodwin had previously had involvement in the areas of education and research with pharmaceutical companies. However, what we were not aware of, at any time, until we received the call from Gardiner Harris at the New York Times on 20 November 2008, was that he had business and marketing relationships with pharmaceutical companies, even though he was required under his strict conflict of interest agreement that he signed to disclose those relationships to us . ”

Senator Grassley, an Iowa Republican, has been investigating financial links between doctors and drug companies for some time ( BMJ 2008;337:a2363, doi:10.1136/bmj.a2363; 2008;337:a2315, doi:10.1136/bmj.a2315; 2008;337:a2088, doi:10.1136/bmj.a2088; 2008;337:a930, doi:10.1136/bmj.a930; 2008;337:a929, doi:10.1136/bmj.a929; …