tbuckley/cabot-search huggingface dataset:
Null cell senescence and its potential significance to the immunobiology of aging.
Authors: J J Twomey, R J Luchi, N M Kouttab
Journal: Journal of Clinical Investigation (1982)

The null cell compartments of human bone marrow and mouse spleen were arbitrarily divided into three subpopulations based upon the ability of cells to acquire T or B cell membrane markers when incubated with poly A:U or ubiquitin. There was an accumulation of T cell precursors with congenital absence of the thymus. In contrast, T cell precursors were reduced and there was an accumulation of uninduced null cells with old age. These observations suggest that there is an intrinsic defect of null cell differentiation with a drift towards more differentiated precursors in T cell differentiation with aging. This could result in a diminution in the range of responses by their progeny, mature T lymphocytes.
420 Steatosis, oxidative stress and fibrosis in chronic hepatitis C
Authors: L FARTOUX, L SERFATYSR, G LEFEVRE, M CONTI, A POUJOLROBERT, J CAPEAU, R POUPON
Journal: Hepatology (2003)

Infections of bacteria and viruses induce host defense reactions known as innate responses that include the production of cytokines and chemokines. The production of type I interferon (IFN) is known to be induced by viral double-stranded (ds) RNA or bacterial lipopolysaccharide (LPS). Although important functions for the transcription factors NF-κB and interferon regulatory factor-3 (IRF-3) are indicated, the molecular signals leading to the activation of IFN genes have yet to be elucidated. We provide several lines of evidence that LPS and dsRNA trigger distinct intracellular signals upstream. Notably, our investigation revealed a critical function for TIRAP/MAL, a signaling adapter for Toll-like receptor (TLR) 4, in LPS-induced but not dsRNA-induced activation of IRF-3. These results highlight cross-talk between TLR-mediated and virus/dsRNA-induced signals resulting in activation of the IFN system.
<i>By the River</i>
Authors: Jeanette M. Smith
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Case of Osteo-Plastic Resection of the Foot by the Method of Mickulicz
Authors: W. MacCormac
Journal: BMJ (1888)

The velocity of the wind is not giveni but I may.say that in the interior of the^State what sailors cll a moderate gale" i8spr,actic- ally unknown.I have but .seldom.seen even a stiff, breeze" in the capital city.These facts and figures aYre submitted without extended comment.We who live in the Far.West are, perhaps, too apt to boast of our " glorious iclim;&te," bht those oly who have .exitUdfor years in less hospitable regions .can.hpprediate!what ittruly is.FPor persons.ofcomfortable or ample ,eme Californis.easy of access, and can be reached!in'eighteen,.dysfromiany point 'of departu're in the United Kingdom.' 'e 'jodrney can be, .made in comfort and even' luxury.By the.Rbyal Mail and FPaciie Mlail the trip oan be made'almost wholly by,sea, and for good sailors it is the easiest way to travel.
A new paradigm?
Authors: John D. Bonvillian, Francine G. P. Patterson
Journal: Behavioral and Brain Sciences (2002)

Shanker &amp; King argue for a shift in the focus of ape language research from an emphasis on information processing to a dynamic systems approach. We differ from these authors in our understanding of how this “new paradigm” emerged and in our perceptions of its limitations. We see information processing and dynamic systems as complementary approaches in the study of communication.
Hypoxia-Inducible Factor 1-Alpha Reduces Infarction and Attenuates Progression of Cardiac Dysfunction After Myocardial Infarction in the Mouse
Authors: Masakuni Kido, Lingling Du, Christopher C. Sullivan, Xiaodong Li, Reena Deutsch, Stuart W. Jamieson, Patricia A. Thistlethwaite
Journal: Journal of the American College of Cardiology (2005)
Primary Care Management of Non–English-Speaking Refugees Who Have Experienced Trauma
Authors: Sondra S. Crosby
Journal: JAMA (2013)

Refugees are a vulnerable class of immigrants who have fled their countries, typically following war, violence, or natural disaster, and who have frequently experienced trauma. In primary care, engaging refugees to develop a positive therapeutic relationship is challenging. Relative to care of other primary care patients, there are important differences in symptom evaluation and developing treatment plans.To discuss the importance of and methods for obtaining refugee trauma histories, to recognize the psychological and physical manifestations of trauma characteristic of refugees, and to explore how cultural differences and limited English proficiency affect the refugee patient-clinician relationship and how to best use interpreters.MEDLINE and the Cochrane Library were searched from 1984 to 2012. Additional citations were obtained from lists of references from select research and review articles on this topic.Engagement with a refugee patient who has experienced trauma requires an understanding of the trauma history and the trauma-related symptoms. Mental health symptoms and chronic pain are commonly experienced by refugee patients. Successful treatment requires a multidisciplinary approach that is culturally acceptable to the refugee.Refugee patients frequently have experienced trauma requiring a directed history and physical examination, facilitated by an interpreter if necessary. Intervention should be sensitive to the refugee's cultural mores.
Susceptibility to hepatitis A in patients with chronic liver disease due to hepatitis C virus infection: Missed opportunities for vaccination
Authors: Michael Shim, Inessa Khaykis, James Park, Edmund J. Bini
Journal: Hepatology (2005)

Abstract Hepatitis A virus (HAV) superinfection is associated with a high risk of liver failure and death in patients with underlying chronic liver disease. Although HAV vaccination is recommended for all patients with chronic hepatitis C virus (HCV) infection, little is known about adherence to these recommendations in clinical practice. The aims of this study were to determine the frequency of HAV testing and vaccination among patients with chronic HCV infection. We conducted a retrospective cohort study of 1,193 patients diagnosed with chronic HCV infection over a 1-year period. During 1,646 person-years of follow-up, patients were seen by their primary care provider a median of 10.0 times (interquartile range, 4.0-20.0). HAV antibody testing was performed in 640 subjects (53.6%), and 317 (49.5%) of those tested were susceptible (HAV antibody negative). Only 94 of the 1,193 patients (7.9%) received the HAV vaccine, including 26.8% of the 317 susceptible patients, 0.9% of the 323 patients who were already immune to HAV, and 1.1% of the 553 subjects who were never tested. Among the 94 vaccinated patients, 45 received only one dose of the vaccine. Three of the unvaccinated patients developed acute HAV infection during follow-up, and 1 of them died of acute liver failure. In conclusion , despite published recommendations to vaccinate against HAV in patients with chronic HCV infection, we found that HAV testing and vaccination rates were low in clinical practice. Public health programs to increase awareness about HAV vaccination in patients with chronic liver disease are needed. (Hepatology 2005.)
Understanding the Recent Growth in Medicare Physician Expenditures
Authors: John Holahan
Journal: JAMA (1990)

This study employs several large Health Care Financing Administration data sets for 1983 and 1985 to examine the recent growth in Medicare physician services. The study concludes that the recent growth (approximately 15% in real terms between 1983 and 1985) has been more rapid in areas with higher incomes per capita and suggests that this may be related to faster adoption and diffusion of new medical technologies in these areas. The volume of physician services had grown considerably faster for those specialists who utilize newer procedures and technologies than for those who do not. The study also provides evidence that the sharp increase in assignment rates in recent years because of the introduction of the physician participation program also contributed to the growth in physician services during this period. Medicare's prospective payment system, which controlled hospital payments and encouraged hospitals to become more efficient, had at most a small positive impact on the growth in Part B spending. Finally, the freeze on physicians' fees did not seem to have had a major impact on the volume of physician services. (<i>JAMA</i>. 1990;263:1658-1661)
Abstract 1378: Preclinical efficacy of the triple VEGFR inhibitor tivozanib (AV-951) in chimeric breast and lung tumor models
Authors: Yinghui Zhou, Tong Zi, Angela Bressel, Kristen Jesmer, Darren Potz, Anthony Monti, Joelle Brodeur, William Rideout, Maria Isabel Chiu, Murray O. Robinson, Joerg Heyer
Journal: Cancer Research (2010)

Abstract All solid tumors are thought to require neo-vascularization. Therefore pharmacologic inhibition of angiogenesis may represent an important component for treating many therapeutically challenging tumor types. One attractive anti-angiogenesis agent is the ATP competitive small molecule VEGFR inhibitor tivozanib (AV-951). Tivozanib exhibits picomolar inhibitory activity against all three VEGF receptors, a multi-day T1/2 in humans, and demonstrates robust clinical activity in renal cell carcinoma, the signal tumor type for VEGF pathway inhibition. To test preclinical efficacy of tivozanib in other cancer types, we chose primary mouse tumor models due to their ability to capture the complex heterotypic interactions between tumor cells and the microenvironments. Our mouse tumor model strategy involves stepwise genetic manipulation of embryonic stem (ES) cells and chimera formation to enable direct tumor induction in tissues containing both normal and engineered cells. A HER2 driven breast model as well as an allelic series of lung cancer models containing EGFR, KRAS, or HER2 oncogenes demonstrated that resultant adenocarcinomas arose within surrounding normal tissue and exhibited features of advanced malignancies. In this study, we tested the response of HER2 driven breast tumors as well as KRAS and EGFR driven lung tumors to the VEGFR inhibitor tivozanib in tumor bearing chimeric mice. We observed that although tivozanib treatment conferred significant survival benefit to the tumor bearing mice in all three models, it is not able to eradicate all tumor cells. Response to tivozanib in the breast model is much more heterogeneous than in the lung models, with some tumors exhibiting significant regression while others showing progression on treatment, either initially or after a period of response. In contrast, lung tumors showed more uniform response to tivozanib treatment initially, but tumors quickly grew back upon discontinuation of tivozanib treatment. These results indicate that both breast and lung cancer patients could potentially benefit from sustained anti-angiogenesis therapy, and combination of anti-angiogenesis with tumor targeting agents may be required for enduring efficacy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1378.
Orthogeriatric rehabilitation ward in Nottingham: a preliminary report.
Authors: R V Boyd, E Compton, J Hawthorne, J R Kemm
Journal: BMJ (1982)

patient took periodically.The presentation and clinical aspect in the form of an acute intravascular haemolytic episode, the small doses of drug sufficient to cause the attacks, the brief time lapse between administration and onset of symptoms, and the positive result of direct Coombs test, with notable components on the erythrocyte surface at the time of the attacks, all indicate that the mechanism responsible is of stibophen or "innocent bystander" type.2-5Nalidixic acid should therefore be added to the list of drugs responsible for immune haemolytic anaemia.
A NEW ELECTROCARDIOGRAPH
Authors: Andrew P. D'Zmura
Journal: JAMA (1931)

In 1926, the late Mr. Joseph W. Legg, research engineer of a large industrial company,<sup>1</sup>conceived the idea of applying the oscillograph, an instrument of precision used for many purposes in electrical engineering, to clinical medicine. Through the courtesy of Dr. T. Lyle Hazlett, medical director of the company, the opportunity was given to me to consult with Mr. Legg, and it was decided that the first application of his device would be to electrocardiography. The untimely death of Mr. Legg made it necessary for his associates Mr. Clare Anderson, Mr. H. T. Rights and Mr. R. H. Lewis to solve the technical details involved in adapting the oscillograph to a different range of sensitivity, conforming to the accepted standards used in electrocardiography. The outcome of this work has been a new electrocardiograph. It is a self-contained apparatus, weighing considerably less than any other cardiograph now available. This complete
Win or Lose, Internet Gambling Stakes Are High
Authors: Mike Mitka
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Analysis of Ambulance Accidents in Tennessee
Authors: Paul S. Auerbach
Journal: JAMA (1987)

In an effort to improve our program for ambulance crash and related injury prevention, we analyzed 102 consecutive ambulance accidents. Incidents reported included those that resulted in human injury or in which property damage exceeded $200. Multiple logistic regression was used to determine the association between circumstances reported at the time of the accidents and the risk of injury. Twenty-nine accidents contributed to a total of 65 injured victims, with one death. The variable most strongly associated with the probability of an injury-accident was use of a passenger restraint device. Darkness and occurrence at an intersection were variables showing increased risk, but were not statistically significant. The interaction of variables did not have a combined influence on the incidence of injury. The mean delay to hospital care after an accident was 9.4 minutes. Based on our data, we conclude that passenger restraints for both ambulance attendants and passengers should be mandatory, and we suggest that traffic signals be strictly heeded at intersections and speed limits in urban settings be obeyed. (<i>JAMA</i>1987;258:1487-1490)
Immune-Complex Disease in Typhoid and Paratyphoid Fevers
Authors: ZOHEIR FARID
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 September 1975Immune-Complex Disease in Typhoid and Paratyphoid FeversZOHEIR FARID, M.D., D.T.M. & H., GENE I. HIGASHI, M.D., SC.D., SAMIR BASSILY, M.D., WALTER F. MINER, M.D., M.P.H.ZOHEIR FARID, M.D., D.T.M. & H.Search for more papers by this author, GENE I. HIGASHI, M.D., SC.D.Search for more papers by this author, SAMIR BASSILY, M.D.Search for more papers by this author, WALTER F. MINER, M.D., M.P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-3-432_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The paper "Glomerulitis in Typhoid Fever" (Ann Intern Med81:210-213, 1974) and the comment "Immune-Complex Disease in Typhoid Fever" (Ann Intern Med82:720-721, 1975) are indeed most interesting and important. Few physicians are aware of the occurrence of the nephrotic syndrome inSalmonellainfections. Patients with schistosomiasis and chronicSalmonella typhiorSalmonella paratyphi Abacteremia with or without bacteriuria have features so characteristic that they form a distinct syndrome (1, 2) ; in Egypt, some of these patients develop classic nephrotic syndrome. In 1972, we published a report on five such patients and suggested that under...References1. FARIDBASSILYKENT ZSD: Chronic urinary salmonella carriers with intermittent bacteremia. J Trop Med Hyg 73:153-156, 1970 MedlineGoogle Scholar2. ROCHAKIRKHEAREY HJC: Prolonged salmonella bacteremia in patients with Schistosoma mansoni infection. Arch Intern Med 128:254-257, 1971 CrossrefMedlineGoogle Scholar3. FARIDHIGASHIBASSILY ZGS: Chronic salmonellosis, urinary schistosomiasis, and massive proteinuria. Am J Trop Med Hyg 21:578-581 1972 CrossrefMedlineGoogle Scholar4. HIGASHIFARIDBASSILY GZS: Nephrotic syndrome in Schistosoma mansoni complicated by chronic salmonellosis. Am J Trop Med Hyg 24: July, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ZOHEIR FARID, M.D., D.T.M. & H.; GENE I. HIGASHI, M.D., SC.D.; SAMIR BASSILY, M.D.; WALTER F. MINER, M.D., M.P.H.Affiliations: Division of Immunology Department of Tropical Medicine U.S. Naval Medical Research Unit No. 3 Cairo, Egypt PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySalmonella typhimurium infection leading to acute interstitial nephritisTyphoid and Paratyphoid Fever 1 September 1975Volume 83, Issue 3Page: 432-432KeywordsBacteremiaFeversGlomerulonephritisParatyphoidSalmonellaSchistosomiasisTyphoid ePublished: 1 December 2008 Issue Published: 1 September 1975 PDF downloadLoading ...
Urinary Estrogen Excretion in Men with Breast Cancer
Authors: Thomas L. Dao, Charles Morreal, Takuma Nemoto
Journal: New England Journal of Medicine (1973)

IN 1942 Farrow and Adair1 reported rapid progression of osseous metastases as a result of treatment with testosterone propionate in a male patient with cancer of the breast. In a second male patient, also with osseous metastases from an inoperable breast cancer, these authors performed a bilateral orchiectomy and obtained definite regression of the cancer, including marked decrease in the size of the ulcerative lesion of the breast, calcification of osteolytic bone metastases and complete relief of bone pain. The authors measured the urinary excretion of "estrogenic substance" and 17-ketosteroid before and after treatment and found a marked decrease in . . .
Gastrointestinal disorders in diabetes mellitus
Authors: S R Bloom
Journal: Gut (1986)

In conclusion, it seems that any benefit from raising gastric pH, in critically ill patients, must be balanced against possible problems of Gram-ve pneumonia, crossinfection and wound infection.Because this is the largest study on cimetidine usage in an intensive care unit, it might be valuable for the authors to review their data to ascertain if these problems were significant.
A Department of Health.
Authors: Liston H. Montgomery
Journal: JAMA (1898)

Chicago, July 28, 1898. <h3>To the Editor:</h3> —Congress adjourned, and with the knowledge presumably (see reports of Senator Gallinger and others, from personal observations made while investigating certain parts of Cuba last spring of the great need and urgent necessity of reform in sanitary matters among the unhappy people of that desolate island) or oversight, that legislation upon this all important topic was<i>apparently either relegated to the waste-basket, pigeon-holed or deferred</i>. Call it by whatever term we will. For years the writer, in his feeble efforts, has tried to use what influence he possessed to promulgate argument, why our government should establish a department of health, having at its head an efficient, painstaking, scientific medical secretary. A large majority, perhaps 90 to 95 per cent., of the medical profession throughout our country have favored this project. TheJournalhas repeatedly published the same views. The great majority, as just
Breast Cancer — Early Life Matters
Authors: Karin B. Michels, Walter C. Willett
Journal: New England Journal of Medicine (2004)

Despite improved treatment, mortality rates from breast cancer remain high, partly because of the increasing incidence of the disease. Understanding the causes of breast cancer could ultimately lead to its prevention. Many observations point to early life as a susceptible period in mammary carcinogenesis. Early menarche, late first delivery, and ionizing radiation during early life are documented risk factors. High stature, which to a certain extent is determined by childhood nutrition, has consistently been associated with an increase in the risk of breast cancer.1 Studies in animals also indicate that the mammary gland is most vulnerable to carcinogenic influences before . . .
Poetry and Medicine
Authors: Steven E. Hodes
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal