tbuckley/cabot-search huggingface dataset:
Too Clever Titles
Authors: RICHARD J. KENNEDY
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 February 1976Too Clever TitlesRICHARD J. KENNEDY, M.D., F.A.C.P.RICHARD J. KENNEDY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-2-225_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The title "Echocardiography Manifestation of 'False' Mitral Stenosis That Was" by Ticzon and colleagues in the October issue (Ann Intern Med83:503-505, 1975) is so cute that the logical question follows "that was what?" The article is really about true mitral stenosis with the echocardiographic manifestation of "false" mitral stenosis. Such a grammatical title of course is far from TV jargon and, while not having the commercial appeal of the original, is a more accurate summary of the article. Spare us such cuteness in the future.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 15 West 12th Street New York, New York 10011 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1976Volume 84, Issue 2Page: 225-225KeywordsEchocardiographyForecastingMitral stenosis ePublished: 1 December 2008 Issue Published: 1 February 1976 PDF downloadLoading ...
Summary of Analysts' discussion
Authors: M. S. Moss
Journal: British Journal of Sports Medicine (1976)

LAMBERT: Has anyone seen the presence of ergot or ergot-like materials in horse urine?In Ireland there is a lot of ergot material present in grass; we don't seem able to detect this compound.CHAPMAN: There still seems to be a very wide divergence in the volume of sample used for analysis.Jaggard says he takes 200 ml, we take 120 ml and yet Donike was taking 15 ml.Those people who take very much smaller amounts of urine or even go to the extent of analysing plasma, how wide is their screening procedure?Are you using a very much more limited screen by using the very much smaller volumes?
Rh genotyping: Avoiding false‐negative and false‐positive results among individuals of African ancestry
Authors: G.C. Ekman, R. Billingsly, M.J. Hessner
Journal: American Journal of Hematology (2001)

Abstract High homology, variant alleles, and silent alleles have made the development of completely reliable genotyping assays for the RHD and RHC alleles difficult. An RHD pseudogene ( RHD ψ) possessing a 37‐bp insertion within exon 4 is common among serologically RhD‐negative individuals of African descent and generates false‐positive results in previously reported RhD genotyping assays. Genotyping RhC is problematic due to exon 2 homology between RHD and RHC ; however, an RHC ‐specific 109‐bp insertion within intron 2 has been reported useful for genotyping. Primers flanking the exon 4 insertion point were used for detection of RHD and RHD ψ among a total of 231 serotyped individuals: 134 African American, 85 Caucasian, and 12 RhD serotype‐negative/genotype‐positive, D‐sensitized women. Primers flanking the RHC ‐specific intron 2 insertion were used to genotype 282 serotyped individuals (128 African American, 154 Caucasian) and were compared to RHC genotyping using the exon 1 RhC‐specific nt48 cytosine polymorphism. Complete correlation was observed between genotyping with the RHD ψ primer pair and serotyping among 219 individuals and 10/12 previous RHD false‐positive genotyping results were resolved. RHD ψ was detected in 19% ( n = 4/21) of RhD seronegative African Americans and 4.4% ( n = 5/113) of RhD seropositive African Americans. When using the 109‐bp intron 2 insertion for genotyping of RHC , a 23.9% ( n = 11/46) false‐negative rate was observed among African American RhCc serotyped heterozygotes. Utilization of the exon 1 nt48 cytosine for indirect genotyping of RHC yielded a 7.2% ( n = 4/55) and 56.3% ( n = 45/80) false‐positive rate among Rhcc Caucasians and African Americans, respectively. We conclude that these additional reactions, though not sufficient alone, can be useful supplements to existing Rh genotyping assays. Am. J. Hematol. 69:34‐40, 2002. © 2002 Wiley‐Liss, Inc.
Targeting coeliac disease serology
Authors: D. J. Unsworth, F. J. Smith, R. J. Lock
Journal: BMJ (2012)

We agree that testing first degree relatives of patients with coeliac disease (CD) for gluten enteropathy is worthwhile but caution against less targeted testing, especially in patients with non-specific symptoms.1

The prevalence of CD in England is estimated at 1.0-1.2%.2 3 Prevalence is higher in “at risk” groups: 5-6% in first degree relatives and 6% in people with type …
Increased urinary atrial natriuretic peptide-like immunoreactivity excretion but decreased plasma atrial natriuretic peptide concentration in patients with hyperosmolar-hyperglycemic nonketotic syndrome.
Authors: S J Shin, Y J Lee, P J Hsiao, J H Tsai
Journal: Diabetes Care (1999)

OBJECTIVE: This study was undertaken to measure urinary atrial natriuretic peptide-like immunoreactivity (ANP-LI) and plasma ANP concentration in patients with hyperosmolar-hyperglycemic nonketotic syndrome (HHNS) to investigate the change of renal ANP-LI and cardiac ANP synthesis in volume-depleted diabetic patients. RESEARCH DESIGN AND METHODS: The urine ANP-LI:creatinine ratio, plasma ANP level, and plasma renin activity (PRA) were measured in 12 patients with HHNS during the acute stage and after recovery, in 28 oral hypoglycemic agent (OHA)-treated type 2 diabetic patients, and in 23 normal subjects. ANP and PRA were measured by radioimmunoassay. RESULTS: These HHNS patients had severe hyperglycemia and hyperosmolality as well as increased blood urea nitrogen, creatinine, and PRA levels, as compared with normal subjects and OHA-treated type 2 diabetic patients. In these patients, the urinary ANP-LI:creatinine ratio (11.69 +/- 2.11 pmol/mmol) was significantly increased in comparison with the normal group (1.78 +/- 0.11 pmol/mmol) and OHA-treated diabetic patients (2.43 +/- 0.45 pmol/mmol), whereas plasma ANP concentration (5.12 +/- 0.72 pmol/l) was significantly lower than the corresponding values of the normal group (7.39 +/- 0.85 pmol/l) and OHA-treated diabetic patients (8.43 +/- 1.05 pmol/l). All of these abnormalities were significantly ameliorated after insulin, fluid, and electrolyte replacement. CONCLUSIONS: Our data show that urinary ANP-LI was significantly increased, whereas plasma ANP concentration was decreased, in the face of raised PRA in HHNS patients. This study indicates that renal ANP-LI substances and cardiac ANP may exhibit different responsiveness in diabetic patients with HHNS.
CASES ILLUSTRATING THE ADVANTAGES DERIVABLE FROM THE USE OF THE OPHTHALMOSCOPE
Authors: J. W. Hulke
Journal: BMJ (1854)

Xl with this she pesvered until she removed him from er my care.She then never said a word about the attack of fever, nor about her own stimulating treatment, though no doubt she continued it.In a short time she be- came tired of paying, and took the child to a physician, under whom he died on the 15th of March.REMARKS.The term " continued fever" has often been ob- jected to, at least in a comprehensive sense; nevertheless, until some really better term can be invented, I am perfectly content to retain it.If we refer to Dr. Watson's Lecture on tAe Practice of Physic-which, though a text-book for stu- dents, may with the greatest advantage
Intravenously Injected Human Fibroblasts Home to Skin Wounds, Deliver Type VII Collagen, and Promote Wound Healing
Authors: David T Woodley, Jennifer Remington, Yi Huang, Yingping Hou, Wei Li, Douglas R Keene, Mei Chen
Journal: Molecular Therapy (2007)

Patients with dystrophic epidermolysis bullosa (DEB) have incurable skin fragility, blistering, and multiple skin wounds because of mutations in the gene that encodes for type VII collagen (C7), which holds together the epidermal and dermal layers of human skin. The intradermal injection of gene-corrected DEB fibroblasts, recombinant C7 protein, or lentiviral vectors expressing C7 is a potential therapy for DEB. Nevertheless, severe DEB causes widespread wounds and treatment would require multiple injections. An alternative strategy might be to inject genetically engineered cells into the patient's circulation that home to the skin wounds and deposit the transgene product. In this study, we demonstrated that intravenously (IV) injected, molecularly engineered DEB fibroblasts (overexpressing human C7) homed to murine skin wounds and continuously delivered C7 at the wound site, where it incorporated into the skin's basement membrane zone and formed anchoring fibril structures. Wounds made on murine or grafted human skin demonstrated accelerated healing when the animals were IV injected with gene-corrected DEB fibroblasts. Our data demonstrate that abundant C7 promotes wound healing. This is also the first evidence that IV injected, molecularly engineered skin fibroblasts can deliver C7 to skin wounds. This strategy could be useful for treating DEB patients. Patients with dystrophic epidermolysis bullosa (DEB) have incurable skin fragility, blistering, and multiple skin wounds because of mutations in the gene that encodes for type VII collagen (C7), which holds together the epidermal and dermal layers of human skin. The intradermal injection of gene-corrected DEB fibroblasts, recombinant C7 protein, or lentiviral vectors expressing C7 is a potential therapy for DEB. Nevertheless, severe DEB causes widespread wounds and treatment would require multiple injections. An alternative strategy might be to inject genetically engineered cells into the patient's circulation that home to the skin wounds and deposit the transgene product. In this study, we demonstrated that intravenously (IV) injected, molecularly engineered DEB fibroblasts (overexpressing human C7) homed to murine skin wounds and continuously delivered C7 at the wound site, where it incorporated into the skin's basement membrane zone and formed anchoring fibril structures. Wounds made on murine or grafted human skin demonstrated accelerated healing when the animals were IV injected with gene-corrected DEB fibroblasts. Our data demonstrate that abundant C7 promotes wound healing. This is also the first evidence that IV injected, molecularly engineered skin fibroblasts can deliver C7 to skin wounds. This strategy could be useful for treating DEB patients.
Credentialing, Recertification, and Public Accountability
Authors: F. Michael Gloth
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic removal of a broken self-expandable metal stent using the stent-in-stent technique
Authors: P. Didden, E. Kuipers, M. Bruno, M. Spaander
Journal: Endoscopy (2012)

A 55-year-old man with dysphagia due to an unresectable distal esophageal adenocarcinoma underwent placement of a 15-cm partially covered self-expandable metal stent (SEMS), diameter 18 mm (Ultraflex; Boston Scientific, Natick, Massachusetts, USA). After 3 months, he presented with recurrent dysphagia. At endoscopy, the meshes of the SEMS had broken, leading to collapse of the SEMS and obstruction of the lumen ([Fig. 1]). Because the patient's clinical condition had improved and further treatment with chemotherapy or radiotherapy was considered, we decided to remove the SEMS using the stent-in-stent technique. A second SEMS, 17-cm long, fully covered, diameter 20 mm (Hanaro, M. I. Tech, Korea) was inserted, overlapping the full length of the first SEMS. After 2 weeks, on endoscopic examination, the loose struts of the disrupted SEMS had perforated the covering of the fully covered SEMS, and the radial pressure of the fully covered SEMS had succeeded in detaching the partially covered SEMS from the esophageal wall and tumor ([Fig. 2]). By pulling the proximal retrieval lasso of the fully covered SEMS, both SEMSs were extracted simultaneously without the need to exert much force.
Microvascular Transfer of Free Tissue for Closure of Bone Wounds of the Distal Lower Extremity
Authors: James W. May, G. Gregory Gallico, Frederick N. Lukash
Journal: New England Journal of Medicine (1982)

Extensive compound fractures of the distal lower extremity may result in chronic infection of the deep tissues and bone if primary healing does not occur. Treatment may require several operations and prolonged hospitalization. In an attempt to improve the management of such problems, 18 patients who had chronic bone-exposure wounds and four patients who had extensive compound fracture wounds of the distal lower extremity were treated with radical debridement, intravenous antibiotics, and microvascular transfer of vascularized tissues for immediate wound closure. All wounds healed, and there was no evidence of recurrent infection during a mean follow-up period of 19.3 months in the patients with chronic wounds and 16.3 months in those with acute wounds. In selected patients this free-tissue-transfer method of wound closure appears to have considerable advantages over conventional methods of management.
Healing Words: The Power of Prayer and the Practice of Medicine
Authors: J. Roberts
Journal: BMJ (1995)

Throughout history, healing and religion have been inseparable. Only in the past 400 years, especially in the West, have the two disjoined enough for George Eliot to write in Middlemarch, “It is seldom a medical man has true religious views--there is too much pride of intellect.”

Larry Dossey, a doctor in New Mexico, would rebut Eliot. Prayer, he says, is--and should be--integral to healing and to the practice of medicine. Before seeing patients each day, he takes time in his office to pray--or meditate, since he believes the two are the same. (He also repeatedly says that his prayers are his own and he would not reveal his beliefs to his patients.)

“Never once did I pray for specific outcomes-- for cancers to go away, for heart attacks to be healed, for diabetes …
THE EFFECT OF ACETYLCHOLINE ON THE HUMAN PULMONARY CIRCULATION UNDER NORMAL AND HYPOXIC CONDITIONS1
Authors: H. W. Fritts, P. Harris, R. H. Clauss, J. E. Odell, A. Cournand
Journal: Journal of Clinical Investigation (1958)

It is generally accepted that the tone of the peripheral arterioles plays an important part in regulating the systemic blood pressure in man.Whether the small vessels of the lungs exercise similar control over the pressure in the pulmonary artery is not so certain.This uncertainty has stemmed largely from the fact that the human pul- monary vessels have exhibited an erratic response to many vasoactive drugs (1-15).As a conse- quence, most physiologists have concluded either that the pulmonary vessels are incapable of in- trinsic changes in tone, or that the effect of such changes, if they occur, is less important in deter- mining the pulmonary arterial pressure than is the effect of mechanical factors alone.There is, however, considerable evidence to suggest that acute hypoxia increases the pul- monary vascular tone (16)(17)(18)(19)(20).This stimulus raises the pulmonary arterial pressure by a greater amount than might be expected to result from the increase in blood flow which occurs.Moreover, the pulmonary wedge and systemic pressures are not altered (19), and there is no consistent varia- tion in the central blood volume (19,21).From these observations it may be inferred that hypoxia constricts the vessels of the lungs.Active dilatation of these vessels has not been so adequately demonstrated.Most drugs which lower the pulmonary arterial pressure have a con- comitant action on the systemic pressure, and it
Gastrointestinal Series in Patients With Gallstones-Reply
Authors: Morton H. Leonard
Journal: JAMA (1978)

We do not oppose the performance of both an oral cholecystogram and an upper GI series in patients regarding whom differentiation between diseases involving the two systems is difficult. We would never suggest that a patient with classic peptic ulcer symptoms and gallstones not have a GI series.  We did not conclude that a GI series is unnecessary in patients with gallstones. What we did was examine the films of 100 patients defined in a particular way and demonstrate a potentially important abnormality by upper GI series in only four of them. In our patients, the GI series had a relatively low yield of identifying abnormalities in patients with gallstones in the absence of GI bleeding or suspicion of GI cancer.
High Altitude Illness
Authors: Lindsay B. Smith
Journal: JAMA (1977)

<h3>To the Editor.—</h3> In response to Dr Charles S. Houston's article entitled "High Altitude Illness: Disease with Protean Manifestations" (236:2193, 1976), may I say that I was fascinated by this phenomenon during the six years I served as director of the Methodist Hospital in La Paz, Bolivia (elevation 3,750 m). It was common to see patients with acute gastrointestinal mesenteric edema, cerebral edema, pulmonary edema, or a combination of the three. My own personal experience was limited to an inability to sleep well for about one week after arrival in the altitude. Several of the US Embassy and US AID personnel, as well as some of the missionaries stationed in La Paz, experienced repeated episodes of pulmonary edema each time they returned to La Paz from a lower altitude. Interestingly, it was a common problem among children during their adolescent years, even though several of them had been born in
Points from Letters: Prevention of Coronary Disease
Authors: T. J. Burke
Journal: BMJ (1971)

Analyzer.The conditions remained identical apart from increased concentration of indicator enzymes.3Normal ranges were determined for each system on blood drawn from healthy volunteers.The results are given in the Table .The range for asparate amino- transferase was much narrower with the LKB instrument, the upper limit of normal falling by 8 units.This was due to the standard deviation being virtually halved, since the mean was similar to the previous value.Instrument No.
BMJ tackles FDA's mote in eye while ignoring own beam
Authors: S. Senn
Journal: BMJ (2011)

Godlee implies that the US Food and Drug Administration (FDA) should be blamed for reversing its decision when it realises it has made a mistake.1 Only two months ago an FDA panel voted to withdraw the breast cancer drug bevacizumab, which had been given “accelerated approval” in 2008.2 Fast track approval: is that foreign to the medical press? Well, ’pon my soul, what …
AB0851 The effects of physiotherapy on respiratory functions and quality of life in ankylosing spondylitis patients
Authors: E. Bolac, H. Guler, A.D. Turhanoglu, S. Genc, C. Özer, N. Ustun
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Ankylosing spondylitis (AS) is a chronic inflammatory disease. AS causes restrictive respiratory disorder by limiting the expansion of the chest. <h3>Objectives</h3> Our study was planned to evaluate the effect of physiotherapy programme on pulmonary function tests and quality of life in Ankylosing spondylitis patients <h3>Methods</h3> Fourty AS patients (16 F,24 M) were enrolled in this study. The disease duration, morning stiffness, Schober tests, chest expansion, Erythrocyte Sedimentation Rate (ESR) and C Reactive Protein(CRP) were analyzed and recorded. On the first month of the study, a physiotherapy program was applied in the therapy unite 2 days in every week. A home program including range of motion strenghtening posture and, respiratory exercises 20-30 minutes in every day was prescribed. All the patients received an education and brochure about home exercise programme during the second and the thirth months. The pain was evaluated using visual analog scale (VAS). Disease activity was evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Pulmonary function tests (FEV1, FEV1/FVC, FVC) were performed with spirometry. Quality of life was evaluated by Health Asssesment Questionnaire Spondyloarthropaties (HAQS). <h3>Results</h3> The mean disease duration of the patients was 5.83±5.88. Pre and post exercise scores were calculated and compared for each parameter. VAS and BASDAI values significantly decreased after exercises (p=0.012, p=0.020 respectively), while Schober, FEV1 and FEV1/FVC values significantly increased after exercises (p=0.019, p=0.025, p=0.010 respectively). There was an improve in HAQS scores after the physiotherapy programme, however it was not statistically significant. <h3>Conclusions</h3> Our study showed that physiotherapy programme can be effective for the management of pain, disease activity and respiratory functions. <h3>References</h3> Karapolat H, Akkoc Y, Sari I, Eyigor S, Akar S, Kirazli Y, Akkoc N,Comparison of group-based exercise versus home-based exercise in patients with ankylosing spondylitis: effects on Bath Ankylosing Spondylitis Indices, quality of life and depression. Clin Rheumatol.2008 Jun;27(6):695-700. Lubrano E, D'Angelo S, Parsons WJ, Corbi G, Ferrara N, Rengo F, Olivieri IEffectiveness of rehabilitation in active ankylosing spondylitis assessed by the ASAS response criteria. Rheumatology (Oxford), 2007 Nov;46(11):1672-5. Analay Y, Ozcan E, Karan A, Diracoglu D, Aydin R. The effectiveness of intensive group exercise on patients with ankylosing spondylitis. Clin Rehabil, 2003 Sep;17(6):631 Fernández-de-Las-Peñas C, Alonso-Blanco C, Alguacil-Diego IM, Miangolarra-Page JCOne-year follow-up of two exercise interventions for the management of patients with ankylosing spondylitis: a randomized controlled trial. Am. J. Phys.Med.Rehabil, 2006 Jul;85(7):559-67. <h3>Disclosure of Interest</h3> None Declared