tbuckley/cabot-search huggingface dataset:
RT-20 * DELAYING RADIOTHERAPY IN 1p19q CO-DELETED AND PARTIALLY DELETED GLIOMAS
Authors: M. G. McNamara, H. Jiang, M. J. L. Fat, S. Sahebjam, T. R. Kiehl, J. Karamchandani, C. Coire, C. Chung, B.-A. Millar, N. Laperriere, W. P. Mason
Journal: Neuro-Oncology (2014)

BACKGROUND: Radiotherapy with procarbazine, lomustine and vincristine improves overall survival (OS) in patients with 1p19q codeleted anaplastic oligodendroglioma (AOD)/anaplastic oligoastrocytoma (AOA). This retrospective study investigates outcomes with upfront temozolomide (TMZ) deferring radiotherapy in 1p19q codeleted/partially deleted AOD, AOA, oligodendroglioma (OD) or oligoastrocytoma (OA). METHODS: Patients with 1p19q codeleted/partially deleted AOD, AOA, OD and OA were analyzed for OS and progression-free survival (PFS) using Kaplan-Meier method. RESULTS: A total of 106 patients (Dec 97-Dec 13) were included. Median age was 40 years (19-66), 58 (55%) male, performance status (PS) 0 in 80 (75%) patients. 1p19q status; codeleted in 66 (62%), incompletely codeleted in 27 (25%), 1p or 19q loss alone in 4 (4%) and 9 (8%) patients respectively. Reason for presentation was seizures in 79 (75%), frontal lobe tumor location in 62 (58%) and contrast enhancement in 50 (47%). Upfront treatment was given in 72 (68%) patients; TMZ alone in 52 (49%) was well tolerated with med 12 cycles (1-24). Median time to radiotherapy in 47 patients (44%), 34.7mo. Median time to radiotherapy in AOD, AOA, OD, OA was 22.4mo, 1.4mo, 43.2mo and 43.4 mo respectively, given in median 3rd line of treatment (range 2-4), 41.2 mo (16.3-93.2) in 9 patients with codeleted/incompletely codeleted AOD who received upfront TMZ alone. Median OS was not reached for all groups (median follow up 5.1yrs). Median time to treatment for 36 patients with 1p19q codeleted/partially deleted AOD/AOA treated with TMZ alone upfront was 49.5 days (range 9-2248), median PFS was 46.3 months. On multivariable analysis, PS 1 vs 0 (Hazard ratio [HR]2.78, 95%confidence interval[CI] 1.57-4.93, p < 0.001) and 1p19q codeletion/incomplete deletion vs 1p or 19q loss alone (HR0.36, 95%CI 0.18-0.74, p = 0.005) were prognostic for PFS. Isocitrate dehydrogenase-1 status is pending. CONCLUSION: Delaying radiotherapy in 1p19q codeleted/incompletely deleted AOD/AOA may be a treatment option.
Successful treatment of epidermolysis bullosa acquisita with mesalazine
Authors: B.N. Robinowitz, D.S. Towery, S.W. Meyers, W.J. Durick, J.W. Taira
Journal: British Journal of Dermatology (1997)

Journal Article Successful treatment of epidermolysis bullosa acquisita with mesalazine Get access B.N. Robinowitz, B.N. Robinowitz Universitiy of Oklahoma Health Sciences Center, Department of Dermatology. 619 N.E. 13th Street, Oklahoma City, OK 73104. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar D.S. Towery, D.S. Towery Universitiy of Oklahoma Health Sciences Center, Department of Dermatology. 619 N.E. 13th Street, Oklahoma City, OK 73104. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar S.W. Meyers, S.W. Meyers Universitiy of Oklahoma Health Sciences Center, Department of Dermatology. 619 N.E. 13th Street, Oklahoma City, OK 73104. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar W.J. Durick, W.J. Durick Universitiy of Oklahoma Health Sciences Center, Department of Dermatology. 619 N.E. 13th Street, Oklahoma City, OK 73104. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J.W. Taira J.W. Taira Universitiy of Oklahoma Health Sciences Center, Department of Dermatology. 619 N.E. 13th Street, Oklahoma City, OK 73104. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 1, 1 July 1997, Pages 154–155, https://doi.org/10.1111/j.1365-2133.1997.tb03725.x Published: 01 July 1997
I-123 MIBG Uptake in a Gastrointestinal Stromal Tumor (GIST)
Authors: Kottekkattu K. Balan, Luke I. Sonoda, Davina Pawaroo
Journal: Clinical Nuclear Medicine (2010)

I-123 metaiodobenzylguanidine (MIBG) scintigraphy is the examination of choice for visualizing tumor sites of pheochromocytoma. We report a middle-aged woman with incomplete Carney's Triad (association of pheochromocytoma/paraganglioma, gastrointestinal stromal tumor [GIST], and pulmonary chondromas) in whom a GIST was identified on the basis of its MIBG uptake. She had undergone surgical resection of a pheochromocytoma and postoperatively developed a mass in the epigastrium, which was thought to be recurrence. The lesion was MIBG-positive. However, following surgery, histologic examination of the specimen revealed findings suggestive of GIST.
Changes in technical regulations and drivers’ safety in top-class motor sports
Authors: G Lippi, G L Salvagno, M Franchini, G C Guidi
Journal: British Journal of Sports Medicine (2007)

Motor racing is a dangerous sport and an inherently risky activity. The organisers of top-class motor sports championships, Formula One and MotoGP, have agreed on a set of regulations to reduce speed and improve safety over the last 10 years. These changes include limitations in weight, fuel and engine capacity. Nevertheless, there is evidence that most of the restrictions that have been introduced over the past 10 years have failed slow down vehicles, since the lap times have decreased almost linearly from 1995 to 2006 and drivers continue to die or to sustain serious injuries that keep them away from competition. Therefore, new and efficient measures should be adopted, such as lowering the cornering speed, having heavier and safer vehicles, having barriers surrounding the track to protect both spectators and competitors better, and having innovative clothing and protective devices to defend key anatomical structures while minimising the hindrance to the rider.
Abstract 5307: VEGF downregulation by HSP90 inhibitor NVP-AUY922 visualized with 89Zr-bevacizumab PET in triple negative breast cancer (TNBC)
Authors: Anton Terwisscha van Scheltinga, Marjolijn Lub-de Hooge, Jos Kosterink, Hetty Timmer-Bosscha, Mikhail Akimov, Elisabeth de Vries, Carolien Schröder
Journal: Cancer Research (2011)

Abstract Zirconium-89 (89Zr) labeled bevacizumab visualizes tumor vascular endothelial growth factor (VEGF) excretion in vivo, and can therefore serve as a potential biomarker for targeted drugs affecting VEGF levels. TNBC is more dependent upon alternative routes for their maintenance, such as angiogenesis, than hormone receptor or HER2 positive breast cancer. HSP90 inhibitors are known to impact the angiogenesis pathway via degradation of HSP90 client proteins such as HIF1α and VEGFRs, and in vitro studies have shown that breast cancer cells (including TNBC) are sensitive to these compounds. The aim of this study was to image modulation of VEGF expression in response to HSP90 inhibition with NVP-AUY922, a highly potent non-geldamycin HSP90 inhibitor, in a mouse model with a TNBC xenograft. Methods: Three groups of animals were used in this study, a control (n = 6), treated (n = 7) and placebo (n = 6) group. Twenty-two days after inoculation of TNBC cell line MDA MB-231, all mice received co-injection of 89Zr-bevacizumab and Indium-111 (111In) labeled IgG as aspecific control. VEGF-PET was performed 144 h after tracer injection. Ex vivo biodistribution studies were performed in the control group after the first scan week, for the treatment and placebo group after the second scan week, which was after 3 weeks of treatment. The control group received no treatment, the treatment and placebo group received respectively 50 mg/kg NVP-AUY922 or vehicle every-third-day (q3d) administrated intraperitoneally. Treatment effect was verified with histological response. Results: VEGF-PET showed a decreased 89Zr-bevacizumab tumor uptake of 44% (P = 0.0021) after 3 weeks NVP-AUY922 treatment compared to the baseline scan. Placebo treated mice showed no significant difference in bevacizumab uptake. These in vivo imaging data were supported by ex vivo biodistribution data. IgG tumor uptake was in all groups consistent, indicating that there was no influence on tumor perfusion due to the anti-angiogenic treatment. VEGF downregulation in the tumors was shown by immunohistochemistry of VEGF-A. Conclusion: NPV-AUY922 downregulates VEGF in a TNBC mouse model. VEGF-PET using 89Zr-bevacizumab can be used in vivo to monitor downregulation of VEGF excretion in response to HSP90 inhibition, and can therefore potentially serve as biomarker for early HSP90 inhibition effect in TNBC. Supported by a grant of the Dutch Cancer Society. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5307. doi:10.1158/1538-7445.AM2011-5307
Redundancies in NHS trusts: effect on junior house officers
Authors: T Ind, C Gabriel, A Ditchfield, T Howes, T Bunch, H Diaz, H Sawert, S Burling, M Nualart, S Fan, A Hayes, C Hui, P Eweje, C Mcintyre, S Kelly
Journal: BMJ (1991)

I-Responses of 74 trainiees to questions about training, experience, and confidence in minor suirgical protceduires Minor surgical 'Iraining was (ainned Fccl procedures adequate experience contident
Ultrasonics in Ophthalmology: Diagnostic and Therapeutic Applications
Authors: Ephraim Friedman
Journal: JAMA (1968)

Ophthalmic ultrasonography, a new technique, can provide information about the normal and pathologic eye, and it has special value in eyes with opaque media. Acoustic waves with frequencies above the audible range can penetrate the eye, and the pattern of reflection from intraocular tissues can be recorded and studied. In addition, high energy ultrasound, when focused, has thermal and mechanical effects upon the eye, with potential therapeutic applications. During the past decade more than 300 scientific articles have been published on the ophthalmic uses of ultrasound. The attempt of Goldberg and Sarin to summarize this information must be applauded, despite limitations of the book as a reference text. It is a collection of papers of uneven quality. Most of the contributors are recognized authorities; some, including the editors, have had relatively brief experience in the field. Absent from the contributors is Gilbert Baum. Included in the book are chapters on
Women and Children Last — The Predictable Effects of Proposed Federal Funding Cuts
Authors: George J. Annas, Wendy K. Mariner
Journal: New England Journal of Medicine (2011)

Provisions of the budget resolution of the U.S. House of Representatives — now up for debate in the Senate — would cut funding for programs in family planning, nutritional assistance, and prenatal care, threatening the health of low-income women and children.
Initial results of combined anterior mitral leaflet extension and myectomy in patients with obstructive hypertrophic cardiomyopathy
Authors: Marcel J. Kofflard, Lex A. van Herwerden, David J. Waldstein, Peter Ruygrok, Eric Boersma, Meindert A. Taams, Folkert J. Ten Cate
Journal: Journal of the American College of Cardiology (1996)
Orthopedic Diseases: Physiology, Pathology, Radiology.
Authors: Louis Lichtenstein
Journal: JAMA (1963)

An authoritative treatise on the pathology of skeletal diseases has long been needed and the second edition of Aegerter and Kirkpatrick's<i>Orthopedic Diseases</i>is a noteworthy step in the right direction. Although their revised monograph is not without its faults, the authors are disarming in that they make no pretense at completeness or of originality. To enhance the clinical usefulness of the new edition, they have added many more roentgenograms, introduced a chapter on arthritis, amplified the discussion of certain metabolic disorders, and enlarged the section on developmental anomalies. The latter has actually become somewhat topheavy, occupying almost 100 pages of text out of some 700 pages in all. There has been an earnest attempt to integrate physiological and biochemical information with pathological observations, but it appears doubtful whether we know enough as yet about the molecular biology of skeletal diseases to use this approach effectively in a textbook dis
Cyclosporine A decreases rat skeletal muscle mitochondrial respiration in vitro.
Authors: J F Hokanson, J G Mercier, G A Brooks
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Cyclosporine A (CsA) is a potent immunosuppressant used to decrease organ rejection after transplantation surgery. Reported limitations to use of CsA have been hepatotoxicity and nephrotoxicity. Additionally, exercise capacity is much less than expected following transplantation even if arterial oxygen transport capacity is repaired. Purposes of the present study were to determine the effects of CsA on skeletal muscle mitochondrial respiration in vitro and to determine the site of the CsA skeletal muscle mitochondrial lesion. Mitochondria were isolated from rat hind limb muscle homogenates after differential centrifugation. Mitochondrial respiration was determined using a Rank oxygen polarograph at 37 degrees C in a sucrose and mannitol respiration medium. CsA inhibited maximal respiration (ADP stimulated) in the presence of succinate and rotenone by 18.3% and in the presence of malate and pyruvate by 34.7%. CsA decreased the rate of uncoupled respiration (addition of carbonyl cyanide p-trifluoromethozyphenylhydrazone) by 19.6% and 32.0% for succinate and rotenone, or pyruvate plus malate, respectively. No significant effect of CsA on ADP/O for either substrate was observed. We conclude that CsA inhibits maximal coupled and uncoupled skeletal muscle mitochondrial respiration in vitro. Moreover, although the effects of CsA were greater on electron flux through Complex I, mitochondrial lesions caused by CsA were not specific to either Complex I or Complex II of the electron transport chain (ETC). Poor exercise performance despite adequate arterial oxygenation and systemic and regional oxygen deliveries in transplant patients may be attributed, in part, to the effects of immunosuppressive therapy on ETC capacity of skeletal muscle mitochondria.
A Gain-of-Function TBX5 Mutation Is Associated With Atypical Holt–Oram Syndrome and Paroxysmal Atrial Fibrillation
Authors: Alex V. Postma, Judith B.A. van de Meerakker, Inge B. Mathijssen, Phil Barnett, Vincent M. Christoffels, Aho Ilgun, Jan Lam, Arthur A.M. Wilde, Ronald H. Lekanne Deprez, Antoon F.M. Moorman
Journal: Circulation Research (2008)

Holt-Oram syndrome (HOS) is a heart/hand syndrome clinically characterized by upper limb and cardiac malformations. Mutations in T-box transcription factor 5 (TBX5) underlie this syndrome. Here, we describe a large atypical HOS family in which affected patients have mild skeletal deformations and paroxysmal atrial fibrillation, but few have congenital heart disease. Sequencing of TBX5 revealed a novel mutation, c.373G>A, resulting in the missense mutation p.Gly125Arg, in all investigated affected family members, cosegregating with the disease. We demonstrate that the mutation results in normal Nkx2-5 interaction, is correctly targeted to the nucleus, has significantly enhanced DNA binding and activation of both the Nppa(Anf) and Cx40 promoter, and significantly augments expression of Nppa, Cx40, Kcnj2, and Tbx3 in comparison with wild-type TBX5. Thus, contrary to previously published HOS mutations, the p.G125R TBX5 mutation results in a gain-of-function. We speculate that the gain-of-function mechanism underlies the mild skeletal phenotype and paroxysmal atrial fibrillation and suggest a possible role of TBX5 in the development of (paroxysmal) atrial fibrillation based on a gain-of-function either through a direct stimulation of target genes via TBX5 or indirectly via TBX5 stimulated TBX3. These findings may warrant a renewed look at the phenotypes of families and individuals hitherto not classified as HOS or as atypical but presenting with paroxysmal atrial fibrillation, because these may possibly be the result of additional TBX5 gain-of-function mutations.
Reduced thymic output, cell cycle abnormalities, and increased apoptosis of T lymphocytes in patients with cartilage-hair hypoplasia
Authors: Miguel A. de la Fuente, Mike Recher, Nicholas L. Rider, Kevin A. Strauss, D. Holmes Morton, Margaret Adair, Francisco A. Bonilla, Hans D. Ochs, Erwin W. Gelfand, Itai M. Pessach, Jolan E. Walter, Alejandra King, Silvia Giliani, Sung-Yun Pai, Luigi D. Notarangelo
Journal: Journal of Allergy and Clinical Immunology (2011)
Can performance related pay work in the health service?
Authors: S Vallely
Journal: BMJ (1994)

Reviewing workload statistics for our department a couple of weeks ago I was not surprised to find that last year we performed almost twice the number of radiological examinations recommended by the Royal College of Radiologists. Since 1990 our outpatient workload has increased by 48%, our inpatient workload by 13%, and our accident and emergency work by 6%. Similar figures could be quoted by most other consultants in the health service. I asked a member of the NHS Executive what effect this workload would have on my remuneration if performance related pay for health care professionals was introduced. The reply came “That is a matter for local negotiation.” “What factors will determine performance related pay for doctors?” “A matter for local negotiation,” was the predictable retort.

Consultation is taking place between the executive and the profession and implementation is reported to be as early as September 1994. What is clear from the answers to my questions is that central guidance on the implementation process is likely to be couched in the vaguest possible terms with ample scope for local interpretation.

Do doctors have anything to fear from the introduction of performance related pay? If a fair, clearly constructed, centrally guided process …
Abstract 498: Anti-invasive potential of alginate microcapsule encapsulating TIMP 2-engineered cells against malignant glioma cells
Authors: Shin Jung, Young-il Jung, Woo-Youl Jang, Tae-Young Jung, Kyung-Sub Moon, In-Young Kim
Journal: Cancer Research (2012)

Abstract Objectives. 293T was genetically modified to secrete tissue inhibitor of metalloproteinase-2 (TIMP-2) (abbreviated as 293TIMP2 cells) and 293TIMP2 cells were encapsulated into alginate microcapsules to produce TIMP-2 protien continuously. Since TIMP-2 is known to inhibit matrix metalloproteinase-2 (MMP-2) expression of tumor cells, it could be inhibit invasion of tumor cells through extracellular matrix. The anti-invasive potential of the microcapsules was studied in vitro against U87MG glioma cells. Experimental. The TIMP-2 gene was transfected to 293T cells and the genetically engineered 293TIMP2 cells were encapsulted into alginate microcapsules. The released TIMP-2 protein was examined with Western blot analysis and the anti-invasive potential against U86MG glioma cells was tested with gelatin zymography for matrix metalloproteinase-2 (MMP-2) and a Matrigel assay for invasion. Results. Cell viability within the alginate microcapsules was properly maintained at a cell density of 5×106 cell density. Since polycationic polymers are helpful to maintain mechanical strength of microcapsules with good cell viability, alginate microcapsules were reinforced with chitosan (0.1 % wt/vol). Expression of TIMP-2 protein in cell lysate and the secreted TIMP-2 into conditioned media were confirmed with Western blot analysis. Alginate microcapsules encapsulating 293TIMP2 cells properly released TIMP-2 protein into the medium and the released TIMP-2 protein was effective in inhibiting MMP-2 expression and invasion of U87MG glioma cells. Conclusion. These results indicated that alginate microcapsules encapsulating 293TIMP2 cells are superior candidates for anti-invasive therapy of glioma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 498. doi:1538-7445.AM2012-498
Genetic similarity, human altruism, and group selection
Authors: J. Philippe Rushton
Journal: Behavioral and Brain Sciences (1989)

Abstract A new theory of attraction and liking based on kin selection suggests that people detect genetic similarity in others in order to give preferential treatment to those who are most similar to themselves. There are many sources of empirical and theoretical support for this view, including (1) the inclusive fitness theory of altruism, (2) kin recognition studies of animals raised apart, (3) assortative mating studies, (4) favoritism in families, (5) selective similarity among friends, and (6) ethnocentrism. Specific tests of the theory show that (1) sexually interacting couples who produce a child are genetically more similar to each other in blood antigens than they are either to sexually interacting couples who fail to produce a child or to randomly paired couples from the same sample; (2) similarity between marriage partners is most marked in the more genetically influenced of sets of anthropometric, cognitive, and personality characteristics; (3) after the death of a child, parental grief intensity is correlated with the child's similarity to the parent; (4) long-term male friendship pairs are more similar to each other in blood antigens than they are to random dyads from the same sample; and (5) similarity among best friends is most marked in the more genetically influenced of sets of attitudinal, personality, and anthropometric characteristics. The mechanisms underlying these findings may constitute a biological substrate of ethnocentrism, enabling group selection to occur.
Vectorcardiographic Investigations on the Auricles
Authors: RUDOLF WENGER, KLEMENS HUPKA, ERWIN WICK
Journal: Circulation (1955)

Vectorcardiography demonstrates very clearly the method of auricular activation and shows its spatial development. This is illustrated and discussed in this paper as it occurs in normal subjects, in a patient with an ectopic auricular pacemaker, and in patients with pulmonary heart disease. Changes similar to those seen in patients with cor pulmonale have been observed in dogs after partial occlusion of the pulmonary artery. Remarkable alterations of the auricular vectorcardiogram have been seen in patients with mitral heart disease after commissurotomy.