tbuckley/cabot-search huggingface dataset:
ANTI-ANTILEADERSHIP—VACCINE
Authors: JOHN H. LAWRENCE
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 September 1968ANTI-ANTILEADERSHIP—VACCINEJOHN H. LAWRENCE, M.D.JOHN H. LAWRENCE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-3-641_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:I have just read the article by Halstead Holman (Ann. Intern. Med. 68: 679, 1968) on antileadership vaccine in medical education that was taken from his Presidental Address at the 1967 meeting of the Western Association of Physicians. When, for the first time in the history of the Association, a Presidential Address was circulated to the membership, I wrote a letter to the President of the Association (and also circulated copies of it to the membership) pointing out that although I was in agreement with much of Dr. Holman's speech, I was very concerned about his inaccurate... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Donner Laboratory and Donner Pavilion University of California Berkeley, Calif. 94720 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1968Volume 69, Issue 3Page: 641-641KeywordsMedical educationVaccines Issue Published: 1 September 1968 PDF DownloadLoading ...
Honey in the treatment of infantile gastroenteritis.
Authors: I E Haffejee, A Moosa
Journal: BMJ (1985)

A clinical study was undertaken using honey in oral rehydration solution in infants and children with gastroenteritis. The aim was to evaluate the influence of honey on the duration of acute diarrhoea and its value as a glucose substitute in oral rehydration. The results showed that honey shortens the duration of bacterial diarrhoea, does not prolong the duration of non-bacterial diarrhoea, and may safely be used as a substitute for glucose in an oral rehydration solution containing electrolytes. The correct dilution of honey, as well as the presence of electrolytes in the oral rehydration solution, however, must be maintained.
Case 33-1982
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Angelo Eraklis, David L. Gang
Journal: New England Journal of Medicine (1982)

Presentation of CaseA 16-year-old boy was admitted to the hospital with the diagnosis of pancreatitis.He was in generally good health until three days earlier, when abdominal pain and vomiting developed shortly after a dinner of spaghetti. He slept poorly, and on the following morning the abdominal pain increased markedly. He was taken to another hospital, where the hematocrit was 45 per cent and the white-cell count 24,000. The glucose was 202 mg per 100 ml (11.2 mmol per liter), the bilirubin 1.5 mg per 100 ml (26 μmol per liter), the calcium 9.9 mg per 100 ml (2.5 . . .
Reducing Job Exposure to Blood-Borne Pathogens
Authors: Charles Marwick
Journal: JAMA (1989)

PROPOSED standards for reducing occupational exposure to blood-borne pathogens, including hepatitis B and human immunodeficiency viruses, are almost ready, according to the Occupational Safety and Health Administration (OSHA). John A. Pendergrass, assistant secretary of labor for OSHA, says one provision will require employers to make hepatitis B vaccine available. Speakers at the Third National Forum on Acquired Immunodeficiency Syndrome and Hepatitis B, held in Washington, DC, pointed out that only one third of health care workers are immunized despite the vaccine's being available since 1982. Last year there were 18 000 cases of hepatitis B among health care workers and nearly 300 deaths. The proposed standards will not be limited to health care workers. This broader scope is being proposed because it is exposure to potentially infectious materials, not specific occupation, that presents the risk, Pendergrass said. Employers will also be required to provide training and acceptable protective equipment such
Abstract 2669: Predicting glioblastoma recurrence using novel analysis of perfusion MRI.
Authors: Luke Macyszyn, Hamed Akbari, Xiao Da, Ragini Verma, Ronald Wolf, Michel Bilello, Elias Melhem, Donald O'Rourke, Christos Davatzikos
Journal: Cancer Research (2013)

Abstract Glioblastoma (GBM) is the most common and aggressive primary brain tumor in humans. Patients diagnosed with GBM have a poor prognosis, with less than 25% of patients surviving more than two years. Despite intensive, multimodality treatment with extensive surgical resection, radiotherapy, and chemotherapy, recurrence of GBM is inevitable. Thus far GBM research has focused mainly on classification of tumor subtypes, segmentation of enhancing and non-enhancing tumor tissue on MRI, and distinguishing treatment-related effects from recurrence. The purpose of this research is to utilize MR perfusion imaging along with advanced image analysis methods to predict specific areas of future recurrence in GBM. Forty patients with glioblastoma (WHO Grade IV), who subsequently experience recurrence, were utilized for this study. T1, T1CE, T2, FLAIR, and perfusion images were co-registered and regions of interest (ROIs) were drawn for each subject on imaging obtained prior to surgery in white matter, gray matter, CSF, edema, enhancing tumor, non-enhancing tumor and necrosis. Principal component analysis (PCA) was then employed to extract the uncorrelated variables that reflect the temporal dynamics of perfusion. Leave-one-out cross-validation was used when building the PCA model from a training set and testing it on new patients. The results demonstrate marked separation between edematous peritumoral regions and peritumoral regions that later recurred. Hence, this study indicates that imaging biomarkers predictive of tumor recurrence can be constructed using advanced imaging and analysis methods, potentially leading to the creation of a novel, and important, clinical tool. Citation Format: Luke Macyszyn, Hamed Akbari, Xiao Da, Ragini Verma, Ronald Wolf, Michel Bilello, Elias Melhem, Donald O'Rourke, Christos Davatzikos. Predicting glioblastoma recurrence using novel analysis of perfusion MRI. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2669. doi:10.1158/1538-7445.AM2013-2669 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
High number of additional genetic lesions in acute myeloid leukemia with t(8;21)/RUNX1-RUNX1T1: frequency and impact on clinical outcome
Authors: M-T Krauth, C Eder, T Alpermann, U Bacher, N Nadarajah, W Kern, C Haferlach, T Haferlach, S Schnittger
Journal: Leukemia (2014)
Ghostwriting Policies in High-Impact Biomedical Journals: A Cross-Sectional Study
Authors: Xavier Bosch, Cristina Hernández, Juan M. Pericas, Pamela Doti
Journal: JAMA Internal Medicine (2013)

Although sound authorship of biomedical journal articles relies on personal and professional integrity and accountability, recent controversies concerning ghostwriting and guest authorship have shown that this approach has limitations.1
Nosocomial Bacterial Meningitis
Authors: Diederik van de Beek, James M. Drake, Allan R. Tunkel
Journal: New England Journal of Medicine (2010)

Nosocomial bacterial meningitis is most often related to either complicated head trauma or invasive procedures, such as craniotomy, placement of ventricular catheters, intrathecal infusion of medications, or spinal anesthesia. In addition, metastatic infection from hospital-acquired bacteremia occasionally leads to meningitis. The conditions are associated with different pathogenetic mechanisms and a different spectrum of microorganisms, and therefore the choice of empirical antimicrobial therapy will vary according to the condition.
Intussusception of Vermiform Appendix in Allergic Children
Authors: R. G. Mitchell
Journal: BMJ (1955)

the localized molecular disruption there results a gradual spread towards the centre.The analogy to fatigue fractures in metals presents itself and would repay further study.It would be interesting to note whether the characters of the fractures in both types are similar.In those of metals the fracture is comparatively smooth at its outer zones where the surfaces have been rubbed together on innumerable occasions prior to the sudden spread of the fracture transversely, this suddenly fractured zone showing relative coarseness.Difficulty remains in affording an explanation for the predominance of this group of fatigue fractures of the fibula in females. SummaryA case of bilateral fatigue fractures of the fibula in a middle-aged woman is reported.Point tenderness, and pain at the same site when the ankle mortise was widened by everting the heels or dorsiflexing the foot, were features of the clinical findings.The site of the fractures was identical with that described by Burrows (1948) in women of middle age.Treatment advised was stirrup strapping and rest.
Carpal tunnel syndrome caused by amyloid containing beta 2 microglobulin: a new amyloid and a complication of long term haemodialysis.
Authors: J McClure, C J Bartley, P Ackrill
Journal: Annals of the Rheumatic Diseases (1986)

Three patients receiving long term haemodialysis treatment for chronic renal failure due to non-amyloid nephropathy developed the carpal tunnel syndrome requiring decompression surgery. The excised material contained amyloid, which by immunocytochemical techniques was shown to contain beta 2 microglobulin. This is, therefore, a new chemical form of amyloid whose deposition is likely to be the cause of osteoarticular and connective tissue disorders, which are being recognised with increasing frequency in patients receiving long term haemodialysis. Raised beta 2 microglobulin levels are known to occur in chronic renal failure, and the molecule is unable to cross conventional dialysis membranes. The importance of beta 2 microglobulin amyloidosis lies in the threat which it poses to the success of long term haemodialysis.
Clinical Forensic Medicine-Reply
Authors: Jane L. Uva
Journal: JAMA (1996)

In Reply.  —The letter from Drs Payne-James and Stark illustrates the international history of clinical forensic medicine. The United Kingdom has more than 40 years of experience in this arena compared with the mere 5-year initiation in the United States. The expansion of the definition of clinical forensic medicine, especially the application of the theory to concrete examples, is beneficial.  To increase the role of clinical forensic medicine in the United States, several obstacles must be overcome. Education of physicians on clinical forensic medicine and application of the techniques on living patients need to be encouraged. Acceptance of these techniques may require research for the benefits and possible complications of using clinical forensic medicine. With all of the changes in health care financing today, clinical forensic medicine will need to prove its economic benefits as a medical discipline vs only a theoretical perspective.  Although clinical forensic medicine is recognized worldwide,
Effect of Dipyridamole on the Incidence of Arterial Emboli After Cardiac Valve Replacement
Authors: JAY M. SULLIVAN, DWIGHT E. HARKEN, RICHARD GORLIN
Journal: Circulation (1969)

Dipyridamole is a vasodilator known to reduce platelet adhesiveness and aggregation. Either dipyridamole or a placebo was given in a daily dose of 400 mg as a random, blind trial to 100 patients who had undergone prosthetic cardiac valve replacement. Patients in both groups were anticoagulated with warfarin sodium. Fifty patients of the placebo group followed for 695 months had 18% incidence of systemic arterial embolism. Forty-two patients in the dipyridamole group were followed for 553 months. One patient exhibited clinical evidence of arterial embolism. Dipyridamole was discontinued shortly after surgery in eight patients followed for 119 months. Two of these patients developed cerebral emboli six months after discontinuation of treatment. It is tentatively concluded that the addition of dipyridamole to a program of anticoagulation reduces the incidence of postoperative arterial emboli originating on prosthetic cardiac valves in those patients who can tolerate the drug.
Use of an Overtube for Enteroscopy: Depth of Insertion
Authors: J. Bureš, S. Rejchrt
Journal: Endoscopy (2002)

We read with interest, in a recent issue, the paper by Taylor et al. entitled “Use of an Overtube for Enteroscopy - Does It Increase Depth of Insertion? A Prospective Study of Enteroscopy with and without an Overtube” [1].
He That Filches from Me My Good Name...
Authors: F. Ronchese
Journal: JAMA (1965)

<h3>To the Editor:—</h3> The paper entitled "Garlic-Clove Fibroma" (<i>JAMA</i><b>191</b>:1082-1083 [March 29] 1965) is most interesting. From the clinical appearance and the pathology my choice of a title would have been "Unusually Large Periungual Koenen's Tumor of Epiloia." A good sized one is illustrated by H. Blank (<i>JAMA</i><b>182</b>:183 [Oct 13] 1962).
The VPH-Physiome Project: Standards and Tools for Multiscale Modeling in Clinical Applications
Authors: Peter J. Hunter, Marco Viceconti
Journal: IEEE Reviews in Biomedical Engineering (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The revolution in molecular biology over the past 50 years has given us an extraordinarily detailed parts list for life, but little understanding of how the parts integrate into the physiological function of the healthy and diseased human body. In contrast, the engineering sciences, from a detailed knowledge of its components, have successfully explained how a plane actually flies. The key difference is the use of mathematical models based on physical principles and a systematic approach to knowledge management. In this review, we describe the efforts of the Virtual Physiological Human (VPH) Physiome Project to address the challenge of integrating molecular, cellular and tissue/organ structure and function through the use of multiscale modeling based on the development of community standards, open source tools and web-accessible databases. We illustrate two applications of the framework, one to cardiology and one to bone fracture prediction in the elderly. </para>
Effect of reduction of anticonvulsants on wellbeing.
Authors: E Fischbacher
Journal: BMJ (1982)

An attempt was made over a period of a year to reduce the number of anticonvulsants used to treat epilepsy in a hospital for the mentally handicapped. At least one drug was withdrawn for each of 20 patients, without loss of seizure control. Effect on wellbeing was assessed by a behavioural scale completed before and after withdrawal, and in the 20 cases of successful withdrawal wellbeing was significantly improved.
Government's demand for raids on abortion clinics cost 580 inspections and 1m, says regulator
Authors: H. Mooney
Journal: BMJ (2012)

The Care Quality Commission (CQC) has hit out against the government claiming it was forced to cancel hundreds of planned inspections of NHS hospitals after health secretary Andrew Lansley ordered it to carry out no notice spot checks on more than 300 abortion clinics in England last month ( BMJ 2012; 344:e2313, doi:10.1136/bmj.e2313).

A letter, published under the Freedom of Information Act, from the commission’s chair Dame Jo Williams to Department of Health officials, shows that fulfilling Lansley’s demand for the unannounced inspections has “clearly impacted on planned regulatory activity by the CQC.” …
Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides.
Authors: H Kasahara, M Itoh, T Sugiyama, N Kido, H Hayashi, H Saito, S Tsukita, N Kato
Journal: Journal of Clinical Investigation (1994)

Autoimmune myocarditis is considered to play a major role in the pathogenesis of dilated cardiomyopathy. A new autoimmune myocarditis model was attained by repeated immunization using murine cardiac C-protein with the immunological adjuvant, Klebsiella pneumoniae O3 lipopolysaccharide. For further analysis of a pathological epitope, the cDNA encoding C-protein was isolated; a fusion protein encoded by part of this cDNA induced myocarditis in SMA mice as well as in three other strains: DBA/1J (H-2q), O20/A (H-2pz1), and SJL (H-2s). The nucleotide sequence and its deduced amino acid analysis revealed that this protein had immunoglobulin-like and fibronectin-like repeats. This study provides a new animal model of autoimmune myocarditis which may shed light on the pathogenesis of dilated cardiomyopathy.
Letter: Streptokinase and heparin in treatment of pulmonary embolism.
Authors: D A Tibbutt, A A Sharp, J M Holt, G Miller, G Sutton
Journal: BMJ (1974)

formed first in patients with massive upper gastrointestinal haemorrhage.If this is un- successful in locating the bleeding point, then arteriography should follow.Vaso- constricting drugs may then be infused if the bleeding site is demonstrated.This may be either the definitive treatment or may allow the patient to undergo surgery in a more stable condition.Those patients in whom stress ulcers6 or varices can be domonstrated by endoscopy are particularly suitable candidates for selective vaso- constrictor infusions if other medical methods fail, since surgery is particularly hazardous in these patients.The performance of these procedures is dependent upon the availability of trained radiologists and technicians and the proper facilities.These requirements are becoming more easily met and are within the reach of most larger hospitals.We feel that the present place and future potential of angio- graphy in gastrointestinal bleeding need to be emphasized.-Weare, etc.,
Sympathetic Stimulation and Arrhythmias
Authors: Douglas P. Zipes
Journal: New England Journal of Medicine (1991)

For many years it has been recognized that sympathetic nervous stimulation can influence the development of cardiac arrhythmias in both normal and abnormal hearts, during ischemic and nonischemic states, and that β-adrenergic—receptor blockade or surgical interruption of the stellate ganglia can prevent these arrhythmias. The mechanism by which the autonomic nervous system precipitates or prevents the arrhythmias is not known. In this issue of the Journal, Meredith et al.1 provide information about the association between sympathetic stimulation and ventricular arrhythmias, demonstrating an almost fivefold increase in cardiac norepinephrine spillover in patients with reduced left ventricular function who had had . . .
Too much information
Authors: T. Dalrymple
Journal: BMJ (2009)

I once read a biography of Somerset Maugham, otherwise excellent, that told me more about his behaviour when demented than I thought I needed—or indeed had any right—to know. Maugham’s literary career was over, and revelations about his dementia could hardly cast any useful light on his work. Just because a fact is biographical does not mean that it should appear in a biography.

What, then, of John Bayley’s account of the dementia of his wife, Iris Murdoch, the philosopher and novelist? It is often touching and sometimes deeply moving, but at other times it tells me, at least, things I would rather not know. I don’t really …
CKIP-1 Inhibits Cardiac Hypertrophy by Regulating Class II Histone Deacetylase Phosphorylation Through Recruiting PP2A
Authors: Shukuan Ling, Qiao Sun, Yuheng Li, Luo Zhang, Pengfei Zhang, Xiaogang Wang, Chunyan Tian, Qi Li, Jinping Song, Hongju Liu, Guanghan Kan, Hongqing Cao, Zengming Huang, Jielin Nie, Yanqiang Bai, Shanguang Chen, Yinghui Li, Fuchu He, Lingqiang Zhang, Yingxian Li
Journal: Circulation (2012)

Sustained cardiac pressure overload-induced hypertrophy and pathological remodeling frequently leads to heart failure. Casein kinase-2 interacting protein-1 (CKIP-1) has been identified to be an important regulator of cell proliferation, differentiation, and apoptosis. However, the physiological role of CKIP-1 in the heart is unknown.The results of echocardiography and histology demonstrate that CKIP-1-deficient mice exhibit spontaneous cardiac hypertrophy with aging and hypersensitivity to pressure overload-induced pathological cardiac hypertrophy, as well. Transgenic mice with cardiac-specific overexpression of CKIP-1 showed resistance to cardiac hypertrophy in response to pressure overload. The results of GST pull-down and coimmunoprecipitation assays showed the interaction between CKIP-1 and histone deacetylase 4 (HDAC4), through which they synergistically inhibited transcriptional activity of myocyte-specific enhancer factor 2C. By directly interacting with the catalytic subunit of phosphatase 2A, CKIP-1 overexpression enhanced the binding of catalytic subunit of phosphatase-2A to HDAC4 and promoted HDAC4 dephosphorylation.CKIP-1 was found to be an inhibitor of cardiac hypertrophy by upregulating the dephosphorylation of HDAC4 through the recruitment of protein phosphatase 2A. These results demonstrated a unique function of CKIP-1, by which it suppresses cardiac hypertrophy through its capacity to regulate HDAC4 dephosphorylation and fetal cardiac genes expression.
Hypocalcaemia in pernicious anaemia.
Authors: G M Fairris, P D Mason, N Fairris
Journal: BMJ (1984)

were first reported by Ryan, but no details of the case were given3; and Rubino and Jackson described a patient who developed confusion and paranoia while receiving tocainide but only after the addition of propranolol to the treatment regimen.5Serum drug concentrations during toxic manifestations may vary widely in different subjects' and in our patients the concentrations of tocainide during toxicity were within the peak therapeutic range (5-15 mg/l, mean 10-3 mg/1).3In each case there was a 48 hour delay between initiating the final tocainide dose regimen and the onset of psychosis.This may be explained by an elimination half life ranging from 10 to 17 hours, which delays the onset of steady state peak drug concentrations and hence toxicity.High peak concentrations and toxi- city may be avoided by administering tablets with food4 and by careful prescription in the presence of propranolol5 and in patients with renal disease, since normally 40% of the unchanged drug is excreted in the urine.'We thank Mr M Stapleton for his help and Drs N Coulshed and E J Epstein for permission to report the cases.