tbuckley/cabot-search huggingface dataset:
Teaching and Training in the Psychiatric-Psychosomatic Consultation-Liaison Setting
Authors: M. Rigatelli, S. Ferrari, U. Uguzzoni, A. Natali
Journal: Psychotherapy and Psychosomatics (2000)

The consultation-liaison (C-L) psychiatrist is in an opportune position to undertake the tasks of education, training and assessment of performance as regards future physicians, psychiatrists, specialists in other branches and nurses. This paper describes the education and training programme in the Psychiatric-Psychosomatic C-L Service of Modena University Hospital.This programme consists of the following main activities: (1) daily group-case supervision, performed by the full-time psychiatrist together with the psychiatry residents of the C-L staff; (2) a bimonthly quality management meeting, which is part of a European project of measurement and improvement of quality of service; (3) weekly lectures on selected topics; (4) monthly tutorials in research techniques; (5) bimonthly presentations of literature reviews; (6) weekly clinical case conferences, which are the nucleus of the curriculum and which focus on the following main topics: 'the patients', 'the intervention' and 'the group', and (7) liaison meetings requested by non-psychiatric departments.A common denominator seen throughout the teaching and training activities of such a programme is the attitude of openness and effort toward integration which should be the C-L psychiatrist's distinguishing mark, in the context of the general hospital.
The Management of Geriatric Cardiovascular Disease
Authors: Charles Fisch
Journal: JAMA (1971)

The book by Dr. Harris says and does exactly what the author intended it to, namely, to "highlight the differences between the young and old cardiac patient." This is particularly true of parts 1 and 3 dealing with normal cardiovascular parameters of aging and special problems in old age. Part 2, which covers specific diseases of the heart, is an excellent summary of clinical cardiology and details the information essential for the management of the average patient with cardiac disease. The book focuses, as does no other standard book on cardiology, on the problems connected with age and particularly the old, and therein lies its main virtue. The text is extremely well written, the illustrations and tables well chosen, clear, and superbly reproduced. There are some minor points of potential difference of opinion. For example on page 30, the late systolic murmur preceded by a click is frequently due to
PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSES
Authors: R. Dulbecco, Marguerite Vogt
Journal: The Journal of Experimental Medicine (1954)

Plaques have been produced with the three types of poliomyelitis viruses on monolayer tissue cultures of monkey kidney and monkey testis. The number of plaques was proportional to the concentration of the virus. Each plaque originates, therefore, from a single virus particle, defined as the virus unit that is unseparable by dilution. The plaques are due to the specific action of the virus since they are suppressed by type-specific antiserum. Pure virus lines were established by isolating the virus population produced in single plaques. These derived virus lines had the same morphological, serological, and pathogenic properties as the parent strain. High titer virus stocks, with titers up to 7 x 10(8) plaque-forming particles per ml., were obtained.
UNUSUAL CASE OF UMBILICAL HERNIA: RUPTURE OF SKIN
Authors: W. J. McGrath
Journal: JAMA (1918)

Mrs. M., aged 78, whose family history was negative, had always been fairly well except for an umbilical hernia, beginning about forty years before, which had become quite large recently. The patient strained while at stool, causing a complete tear of the hernial coverings, including the skin, permitting 15 feet of the intestine and a large part of the omentum to escape from the abdomen. The patient was seen shortly after the accident by Drs. Kriebs and Thine. No attempt was made at this time to replace the herniated intestine and omentum, but the patient was given morphin hypodermically, and the mass was wrapped in gauze wet with physiologic sodium chlorid solution. About four hours elapsed between the time of the accident and the time I saw the patient. She was immediately placed on a kitchen table, and under light ether anesthesia the abdominal tear and the hernial ring were
Neuron-Derived Semaphorin 3A Is an Early Inducer of Vascular Permeability in Diabetic Retinopathy via Neuropilin-1
Authors: Agustin Cerani, Nicolas Tetreault, Catherine Menard, Eric Lapalme, Chintan Patel, Nicholas Sitaras, Felix Beaudoin, Dominique Leboeuf, Vincent De Guire, François Binet, Agnieszka Dejda, Flavio A. Rezende, Khalil Miloudi, Przemyslaw Sapieha
Journal: Cell Metabolism (2013)

The deterioration of the inner blood-retinal barrier and consequent macular edema is a cardinal manifestation of diabetic retinopathy (DR) and the clinical feature most closely associated with loss of sight. We provide evidence from both human and animal studies for the critical role of the classical neuronal guidance cue, semaphorin 3A, in instigating pathological vascular permeability in diabetic retinas via its cognate receptor neuropilin-1. We reveal that semaphorin 3A is induced in early hyperglycemic phases of diabetes within the neuronal retina and precipitates initial breakdown of endothelial barrier function. We demonstrate, by a series of orthogonal approaches, that neutralization of semaphorin 3A efficiently prevents diabetes-induced retinal vascular leakage in a stage of the disease when vascular endothelial growth factor neutralization is inefficient. These observations were corroborated in TgCre-Esr1/Nrp1flox/flox conditional knockout mice. Our findings identify a therapeutic target for macular edema and provide further evidence for neurovascular crosstalk in the pathogenesis of DR.
Startle Reactions to Air-Bag Restraints
Authors: H. Haskell Ziperman
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In his LETTER TO THE EDITOR (235:146, 1976), Mr Decker is incorrect in inferring that the subjects in our study, "Startle Reaction to Air-Bag Restraints," had been told to expect an extraordinary occurrence. They were told that something surprising<i>might occur</i>during some of the rides, but they had no idea that the vehicle used was air bagequipped. That they were startled was evident from the physiological data collected. As noted in our conclusions, "within the limitations of our test design, air-bag deployment or hood fly-up is not likely to produce such a severe startle reaction as to produce an increase in the incidence of accidents in a car in which such an event occurs."
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes
Authors: Sabine Endele, Georg Rosenberger, Kirsten Geider, Bernt Popp, Ceyhun Tamer, Irina Stefanova, Mathieu Milh, Fanny Kortüm, Angela Fritsch, Friederike K Pientka, Yorck Hellenbroich, Vera M Kalscheuer, Jürgen Kohlhase, Ute Moog, Gudrun Rappold, Anita Rauch, Hans-Hilger Ropers, Sarah von Spiczak, Holger Tönnies, Nathalie Villeneuve, Laurent Villard, Bernhard Zabel, Martin Zenker, Bodo Laube, André Reis, Dagmar Wieczorek, Lionel Van Maldergem, Kerstin Kutsche
Journal: Nature Genetics (2010)
Sulfur amino acid metabolism in cystinuria: A biochemical and clinical study of patients
Authors: Johannes Mårtensson, Torsten Denneberg, Åke Lindell, Ola Textorius
Journal: Kidney International (1990)

Sulfur amino acid metabolism was studied in 26 homozygotic cystinuric patients, some of whom received D-penicillamine, 2-mercaptopropionylglycine or N-acetylcysteine treatments in order to evaluate signs of cyst(e)ine deficiency. Decreased leukocyte glutathione and taurine levels, plasma cyst(e)ine and taurine concentrations and urinary inorganic sulfate, taurine, mercaptolactate and thiosulfate outputs were found in cystinuric patients, probably reflecting intracellular cyst(e)ine deficiency. An increased mercaptoacetate-cysteine mixed disulfide output was found, probably as result of a poor tubular reabsorption of this compound, as well as for cystine. Normal retinal function was recorded in all patients. During drug treatments, the excretion of most of the sulfur compounds in cystinurics was as those found in controls, probably reflecting an increased mobilization of cysteine. N-acetylcysteine treatment increased the excretion of cyst(e)ine and can thus not be recommended as stone preventive therapy in cystinuria.
THE EFFECT OF ADRENAL STEROIDS, CORTICOTROPIN, AND GROWTH HORMONE ON RESISTANCE TO EXPERIMENTAL INFECTIONS
Authors: Edward H. Kass, Marguerite M. Lundgren, Maxwell Finland
Journal: The Journal of Experimental Medicine (1954)

Cortisone acetate, hydrocortisone, and hydrocortisone acetate depress the resistance of mice to pneumococcal and influenza viral infections, although hydrocortisone acetate is somewhat less effective than the free alcohol, when given subcutaneously. Pituitary adrenocorticotropin, even in highly purified form and in oil and beeswax, does not significantly alter the resistance of mice to these experimental infections, even when given in doses which may cause profound eosinopenia, lymphopenia, and weight loss, and which are at the limit of tolerance of the animals. Corticosterone depresses resistance to pneumococcal infections significantly, but fails to alter resistance to influenza viral infections. The findings suggest that murine adrenals may produce one of the known adrenal steroids such as corticosterone along with another steroid, or may produce a steroid other than cortisone, hydrocortisone, or corticosterone. When resistance is decreased by adrenal steroids, survival time is invariably shortened, and the effect of the steroid hormones is frequently demonstrable within the 1st day after infection with pneumococci, making it unlikely that the depression of resistance that is seen is primarily due to depression of antibody formation. A single dose of 5 mg. of cortisone may cause depression of resistance and may decrease the survival time for 3 to 6 days afterward. Growth hormone (somatotropic hormone) in highly purified form, and in the doses used, did not overcome the weight loss induced by cortisone, but the animals treated with growth hormone and cortisone regained their lost weight more rapidly than those receiving cortisone alone. Growth hormone alone caused a slight increase in the rate of gain in weight over controls. Growth hormone alone did not increase resistance to infection, and did not increase the survival time, in mice infected with either pneumococci or influenza virus. Growth hormone in various dosages failed to overcome the effect of cortisone in depressing resistance to these infections. Cortisone, hydrocortisone, corticosterone, and corticotropin did not alter significantly the titers of influenza virus attained in the murine lungs during the first 2 days after infection, but cortisone and hydrocortisone markedly delayed the rate at which virus titers declined during the subsequent 6 days. Corticosterone and corticotropin delayed the rate at which the titers declined but slightly, and growth hormone had no apparent effect, as compared with controls. Growth hormone did not overcome the effect of cortisone and hydrocortisone on viral titers. No detectable antibody was found as late as 6 days after infection, in controls or in hormone-treated animals.
Walter B. Cannon: The Life and Times of a Young Scientist
Authors: Lester S. King
Journal: JAMA (1987)

A wobbly line separates biography from history. Telling a dramatic success story, such as that of Walter B. Cannon, is biography. Analyzing the circumstances, trends, and conflicts with which Cannon interacted is history. The present volume is a rare combination of both. Three authors, each with a different expertise, have collaborated on this book: Saul Benison, professor of history at the University of Cincinnati and well known as a medical historian; A. Clifford Barger, professor of physiology at the Harvard Medical School; and Elin L. Wolfe, archivist, working on the Cannon papers. The book rests on a staggering amount of primary source material. The depth of research will excite the admiration of all present and future historians. The presentation of data fits into a smooth contrapuntal scheme, in which problems of science, complexities of education, institutional organization and its special difficulties, and public relations all find an orderly exposition, integrated
An Official American Thoracic Society Clinical Policy Statement: Palliative Care for Patients with Respiratory Diseases and Critical Illnesses
Authors: Paul N. Lanken, Peter B. Terry, Horace M. DeLisser, Bonnie F. Fahy, John Hansen-Flaschen, John E. Heffner, Mitchell Levy, Richard A. Mularski, Molly L. Osborne, Thomas J. Prendergast, Graeme Rocker, William J. Sibbald, Benjamin Wilfond, James R. Yankaskas
Journal: American Journal of Respiratory and Critical Care Medicine (2008)
Does super efficient starch absorption promote diverticular disease?
Authors: J R Thornton, A Dryden, J Kelleher, M S Losowsky
Journal: BMJ (1986)

The amount of starch escaping absorption in the small intestine was measured in eight patients with symptomatic diverticular disease and eight controls. Unabsorbed starch was calculated from breath hydrogen measurements after a potato meal compared with the hydrogen response to lactulose. The proportion of unabsorbed starch was low in all the patients (mean 3.3%) and was only about a quarter of that in the controls (12.4%; p less than 0.01). These findings confirm that unabsorbed starch provides an important quantity of carbohydrate reaching the colon and suggest that super efficient starch absorption, by reducing this provision, may promote the development of diverticular disease.
Calsequestrin mutant D307H exhibits depressed binding to its protein targets and a depressed response to calcium
Authors: T HOULE, M RAM, S CALA
Journal: Cardiovascular Research (2004)

Objective: A point mutation in human cardiac calsequestrin (CSQ-D307H) is responsible for a form of polymorphic ventricular tachycardia (PVT). When overexpressed in heart cells, the mutated CSQ leads to diminished Ca2+ transients, consistent with defective regulation of intralumenal sarcoplasmic reticulum (SR) Ca2+.
TIPS vs. cyanoacrylate injection in the prevention of gastric variceal rebleeding
Authors: G. Lo
Journal: Endoscopy (2008)

I would like to thank Drs. Spahr et al. for their comments on our article regarding the prevention of gastric variceal rebleeding [1]. All of our patients received cyanoacrylate injection at index bleed. The numbers of patients with actively bleeding varices at index endoscopy were shown in Table 1: 13 patients (37 %) in the transjugular intrahepatic portosystemic shunt (TIPS) group and 14 patients (38 %) in the cyanoacrylate group. The mean time from enrollment to initial session of elective treatment was 14 days (range: 7 - 25 days) in the cyanoacrylate group and 4 days (range: 1 - 7 days) in the TIPS group. The mean time from enrollment to first session of elective treatment was thus longer in the cyanoacrylate group than in the TIPS group. This may be partly responsible for the striking difference in rebleeding rates between the two groups. Since all patients had already received cyanoacrylate injection at index bleed, we delayed the initial session of elective treatment in our cyanoacrylate group in order to avoid the occurrence of gastric ulcers induced by repeat cyanoacrylate injection after a short interval [2]. I agree that secondary prophylaxis of variceal bleeding should be started as soon as possible after control of acute hemorrhage. However, the appropriate interval between cyanoacrylate injections for acute treatment and for first elective therapy of gastric varices awaits further investigation. Our results showed the TIPS was more effective than cyanoacrylate injection in reducing variceal rebleeding, with smaller amounts of blood required and similar complication and survival rates. It is for this reason that we suggested that TIPS could be the choice of modality in the prevention of rebleeding from gastric varices. The following interpretation is also possible that although TIPS is more effective than cyanoacrylate injection in reducing gastric variceal bleeding, TIPS is an invasive procedure with the potential to induce hepatic encephalopathy, and hence TIPS should be reserved for patients in whom endoscopic treatment has failed - as in the recommendations in the policy statement by the American Association for the Study of Liver Diseases [3]. Whether TIPS should be the first choice for the prevention of gastric variceal rebleeding depends on the availability of local expertise, the complexity of the patient’s varices, (e. g., concomitant severe esophageal varices and gastric varices), and the patient’s preference. Since hepatic encephalopathy can usually be improved by administration of lactulose, and rebleeding from gastric varices is generally formidable with a high risk of mortality, the choice of TIPS instead of cyanoacrylate injection to prevent gastric variceal rebleeding appears to be the more logical choice. It is indeed the case that more controlled trials are required to verify the role of TIPS in the reduction of variceal rebleeding.
Bone X-ray examinations in patients treated with isotretinoin: a prospective study
Authors: L. Torok, S. Budai, M. Kasa, L. Kadar
Journal: British Journal of Dermatology (1988)

Journal Article Bone X‐ray examinations in patients treated with isotretinoin: a prospective study Get access L. Törok, L. Törok Dermatology Unit, Bács‐Kiskun County Hospital 6000 Keckskemét, Hungary Search for other works by this author on: Oxford Academic Google Scholar S. Budai, S. Budai Radiology Unit, Bács‐Kiskun County Hospital 6000 Keckskemét, Hungary Search for other works by this author on: Oxford Academic Google Scholar M. Kása, M. Kása Dermatology Unit, Bács‐Kiskun County Hospital 6000 Keckskemét, Hungary Search for other works by this author on: Oxford Academic Google Scholar L. Kádár L. Kádár Dermatology Unit, Bács‐Kiskun County Hospital 6000 Keckskemét, Hungary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 118, Issue 1, 1 January 1988, Pages 134–135, https://doi.org/10.1111/j.1365-2133.1988.tb01763.x Published: 01 January 1988
Does diagnostic method influence survival?
Authors: B. Bolsen
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neonatal screening strategy for cystic fibrosis using immunoreactive trypsinogen and direct gene analysis.
Authors: E Ranieri, R G Ryall, C P Morris, P V Nelson, W F Carey, A C Pollard, E F Robertson
Journal: BMJ (1991)

To assess the effectiveness of a two tier neonatal screening strategy for cystic fibrosis, which combines estimation of immunoreactive trypsinogen followed by direct gene analysis in dried blood spot samples collected at age 5 days.Prospective study of two tier screening strategy. The first tier of testing immunoreactive trypsinogen concentration was measured in dried blood spot samples from neonates aged 4-5 days. In the second tier direct gene analysis to detect cystic fibrosis mutations deltaF508 and deltaI506 was performed in those blood spot samples which produced the highest 1% of immunoreactive trypsinogen values. Direct gene analysis was also performed on blood spot samples from infants with suspected or confirmed meconium ileus, regardless of the immunoreactive trypsinogen value.The South Australian Neonatal Screening Programme, operating from the department of chemical pathology at Adelaide Children's Hospital. Subjects--All 12,056 neonates born in South Australia between December 1989 and June 1990. No selection criteria were applied.All infants found to have two recognised cystic fibrosis mutations on direct gene analysis were referred directly for clinical management, and those with one recognised cystic fibrosis mutation were recalled for a sweat test; their families were given genetic counselling.Direct or exclusion of cystic fibrosis by sweat testing of neonates identified as being at high risk of cystic fibrosis on screening and of those at minimum risk but whose subsequent clinical history raised suspicion about the disease.Of the 12,056 infants screened, 11,907 (98.8%) were reported as "cystic fibrosis not indicated" on the basis of low immunoreactive trypsinogen values. Of the 148 (1.23%) infants with raised immunoreactive trypsinogen values and one (0.008%) with meconium ileus, 132 (1.09%) were reported as cystic fibrosis not indicated, four (0.033%) were identified as having cystic fibrosis, and 13 (0.108%) were recalled for sweat testing after direct gene analysis for the presence of the deltaF508 and deltaI506 cystic fibrosis mutations. No cases of affected infants are known to have been missed to date.The strategy of measurement of immunoreactive trypsinogen followed by direct gene analysis is a highly specific neonatal screen for cystic fibrosis, requiring only 2.8 families to be contacted for every case of cystic fibrosis diagnosed.
Case for angioplasty to treat angina
Authors: Martyn R Thomas
Journal: BMJ (2007)

The COURAGE trial results show that patients with stable coronary artery disease who have a good quality of life while receiving medical treatment do not require an angioplasty.1 Coronary angioplasty in the United Kingdom is generally used to treat stable patients who have angina while receiving medical treatment. This trial therefore has little relevance to UK practice.

Of patients randomised, 43% …