tbuckley/cabot-search huggingface dataset:
A Pitfall in the Interpretation of Serum Iron Values
Authors: HASHIM HILAL
Journal: Annals of Internal Medicine (1967)

Diagnosis and Treatment1 May 1967A Pitfall in the Interpretation of Serum Iron ValuesHASHIM HILAL, M.D., PAUL R. MCCURDY, M.D., F.A.C.P.HASHIM HILAL, M.D.Search for more papers by this author, PAUL R. MCCURDY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-983 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMeasurement of the serum iron and the unsaturated iron binding capacity is a valuable adjunct in the diagnosis of iron deficiency anemia (1). A low percent saturation of serum transferrin is the best simple indicator of iron deficiency and helps to differentiate it from other conditions where the serum iron concentration may be low (2). Nevertheless, there are circumstances when the serum iron and the percent saturation of transferrin may be sharply reduced without true iron deficiency. For example, patients with inflammatory disease may have a low percent saturation of transferrin and hypochromic peripheral red cells and a reduced number...References1. WINTROBE MM: Clinical Hematology, 5th ed. Lea & Febiger, Philadelphia, 1961, p. 747. Google Scholar2. BAINTONFINCH DFCA: The diagnosis of iron deficiency anemia. Amer. J. Med. 37: 62, 1964. CrossrefMedlineGoogle Scholar3. HAWKINS CF: Value of serum iron levels in assessing effect of hematinics in the macrocytic anemias. Brit. Med. J. 1: 383, 1955. CrossrefMedlineGoogle Scholar4. MCCURDYDONOHOE PRRF: Pyridoxine-responsive anemia conditioned by isonicotinic acid hydrazide. Blood 27: 352, 1966. CrossrefMedlineGoogle Scholar5. RUBINWEISBERGERBOTTISTORZASLI DASREJP: Changes in iron metabolism in early chloramphenicol toxicity. J. Clin. Invest. 37: 1286, 1958. CrossrefMedlineGoogle Scholar6. HORRIGANHARRIS DLJW: Pyridoxine-responsive anemia: analysis of 62 cases, in Advances in Internal Medicine, vol. XII, edited by DOCK, W., SNAPPER, I. Year Book Medical Publishers, Inc., Chicago, 1964, p. 103. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HASHIM HILAL, M.D.; PAUL R. MCCURDY, M.D., F.A.C.P.Affiliations: Washington, D. C.From the Department of Medicine, Georgetown University School of Medicine, and the Georgetown and Howard Medical Divisions, D. C. General Hospital, Washington, D. C.Requests for reprints should be addressed to Paul R. McCurdy, M.D., D. C. General Hospital, 19th St. and Massachusetts Ave., SE, Washington, D. C. 20003. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCHAPTER 11: Summary to Section IIOxygen therapy in hypoxic chronic bronchitisIron deficiency anemias in childrenSignificance of Iron Measurements 1 May 1967Volume 66, Issue 5 Page: 983-988 Keywords Anemia Attention Cells Folic acid Hospital medicine Iron deficiency Iron deficiency anemia Lactobacillus Megaloblastic anemia ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
THE PRINCIPLES INVOLVED IN THE TREATMENT OF OBESITY
Authors: JAMES S. McLESTER
Journal: JAMA (1924)

To be thin is fashionable. Likewise, if not carried too far, it is conducive to comfort and longevity. It is not my purpose here to discuss the fatty dystrophies, such, for instance, as are believed to result from disease of the endocrine organs, but rather to confine myself to the treatment of ordinary obesity of moderate degree, the type which is best exemplified by that increase in weight which comes with the ease and contentment of middle age. It is this type which we encounter most often. Does the metabolism of the obese patient proceed along lines identical with that of the normal person? Probably not. Yet, in the well known experiment of Rubner<sup>1</sup>on two brothers, one of them fat and the other thin, it was definitely shown that the basal metabolic rate, per square meter of body surface, was the same in the two. We must conclude,
Prognostic Factors in Patients with Non–Muscle-Invasive Bladder Cancer Treated with Bacillus Calmette-Guérin: Multivariate Analysis of Data from Four Randomized CUETO Trials
Authors: Jesus Fernandez-Gomez, Eduardo Solsona, Miguel Unda, Luis Martinez-Piñeiro, Marcelino Gonzalez, Rafael Hernandez, Rosario Madero, Antonio Ojea, Carlos Pertusa, Jesus Rodriguez-Molina, Jose Emilio Camacho, Santiago Isorna, Mariano Rabadan, Ander Astobieta, Manuel Montesinos, Pedro Muntañola, Anabel Gimeno, Miguel Blas, Jose Antonio Martinez-Piñeiro
Journal: European Urology (2007)
<i>In Utero</i> Exposure to Maternal Tobacco Smoke and Subsequent Obesity, Hypertension, and Gestational Diabetes Among Women in The MoBa Cohort
Authors: Lea A. Cupul-Uicab, Rolv Skjaerven, Kjell Haug, Kari K. Melve, Stephanie M. Engel, Matthew P. Longnecker
Journal: Environmental Health Perspectives (2011)

Environmental factors influencing the developmental origins of health and disease need to be identified and investigated. In utero exposure to tobacco smoke has been associated with obesity and a small increase in blood pressure in children; however, whether there is a corresponding increased risk of conditions such as diabetes and hypertension during adulthood remains unclear.Our goal was to assess the association of self-reported in utero exposure to tobacco smoke with the prevalence of obesity, hypertension, type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) in women 14-47 years of age.We conducted a cross-sectional analysis of the Norwegian Mother and Child Cohort Study, which enrolled pregnant women in Norway from 1999 thorough 2008. Exposure to tobacco smoke in utero (yes vs. no) was ascertained on the baseline questionnaire (obtained at ~ 17 weeks' gestation); the outcomes were ascertained from the Medical Birth Registry of Norway and the questionnaire. Our analysis included 74,023 women.Women exposed to tobacco smoke in utero had 1.53 times the odds of obesity [95% confidence interval (CI): 1.45, 1.61] relative to those unexposed, after adjusting for age, education, and personal smoking. After further adjustment for body mass index, the odds ratio for hypertension was 1.68 (95% CI: 1.19, 2.39); for T2DM 1.14 (95% CI: 0.79, 1.65); and for GDM 1.32 (95% CI: 1.10, 1.58) among exposed compared with unexposed.Exposure to tobacco smoke in utero was associated with obesity, hypertension, and GDM in adult women. The possibility that the associations were attributable to unmeasured confounding cannot be excluded.
Properties of PEI-based Polyplex Nanoparticles That Correlate With Their Transfection Efficacy
Authors: Alexey V Ulasov, Yuri V Khramtsov, Georgiy A Trusov, Andrey A Rosenkranz, Eugene D Sverdlov, Alexander S Sobolev
Journal: Molecular Therapy (2010)

We have evaluated the key properties of the polyethylenimine (PEI)-polyethylene glycol (PEG)-TAT peptide polyplex nanoparticles including their behavior in cells and compared them with the transfection efficacy (TE) using 11 different cell lines. We found statistically significant positive correlation between TE and the share of 50–75 nm fraction in the whole mixture of nanoparticles estimated with atomic force microscopy. Variations in PEG/PEI and N/P ratios (PEI nitrogen to DNA phosphate ratio) enabled us to find their optimal combinations, which resulted in up to 100% TE for several cell lines. Surfaces of the TE dependence of both PEG/PEI and N/P turned out to be similar in appearance for all investigated cell lines, while maximum TEs were different. We investigated subcellular transport kinetics and unpacking of the polyplex nanoparticles labeled with quantum dots (plasmid DNA) and AlexaFluor647 (block-copolymer part) using Förster Resonance Energy Transfer approach. The results demonstrated clear and statistically significant positive correlation of TE with the cellular uptake rate of the nanoparticles and negative correlation with the rate constant of their unpacking within endo/lysosomal compartments in the living cells. We have evaluated the key properties of the polyethylenimine (PEI)-polyethylene glycol (PEG)-TAT peptide polyplex nanoparticles including their behavior in cells and compared them with the transfection efficacy (TE) using 11 different cell lines. We found statistically significant positive correlation between TE and the share of 50–75 nm fraction in the whole mixture of nanoparticles estimated with atomic force microscopy. Variations in PEG/PEI and N/P ratios (PEI nitrogen to DNA phosphate ratio) enabled us to find their optimal combinations, which resulted in up to 100% TE for several cell lines. Surfaces of the TE dependence of both PEG/PEI and N/P turned out to be similar in appearance for all investigated cell lines, while maximum TEs were different. We investigated subcellular transport kinetics and unpacking of the polyplex nanoparticles labeled with quantum dots (plasmid DNA) and AlexaFluor647 (block-copolymer part) using Förster Resonance Energy Transfer approach. The results demonstrated clear and statistically significant positive correlation of TE with the cellular uptake rate of the nanoparticles and negative correlation with the rate constant of their unpacking within endo/lysosomal compartments in the living cells.
Sex, Age, and Disease Affect Echocardiographic Left Ventricular Mass and Systolic Function in the Free-Living Elderly
Authors: Julius M. Gardin, David Siscovick, Hoda Anton-Culver, James C. Lynch, Vivienne Elizabeth Smith, H. Sidney Klopfenstein, William J. Bommer, Linda Fried, Daniel O’Leary, Teri A. Manolio
Journal: Circulation (1995)

Background Left ventricular (LV) hypertrophy, as measured by M-mode echocardiography, is an independent predictor of mortality and/or morbidity from coronary heart disease (CHD). LV global and segmental systolic dysfunction also have been associated with myocardial ischemia and cardiovascular morbidity and mortality. Echocardiographic data, especially two-dimensional, have not been available previously from multicenter-based studies of the elderly. This report describes the distribution and relation at baseline of echocardiographic LV mass and global and segmental LV wall motion to age, sex, and clinical disease category in the Cardiovascular Health Study (CHS), a cohort of 5201 men and women (4850 white) 65 years of age and older. Methods and Results M-mode LV mass adjusted for body weight increased modestly with age ( P &lt;.0001), increasing less than one gram per year increase in age for both men and women. After adjustment for weight, LV mass was significantly greater in men than in women and in participants with clinical CHD compared with participants with neither clinical heart disease nor hypertension (both P &lt;.001). Across all CHS age subgroups, the difference in weight-adjusted LV mass by sex was greater in magnitude than the difference related to clinical CHD. M-mode measurements of LV mass could not be made in 34% of CHS participants, and this was highly related to age (29% in the 65 to 69 year versus 50% in the 85+ year age group, P &lt;.001) and other risk factors. In participants with clinical CHD and with neither clinical heart disease nor hypertension, LV ejection fraction and segmental wall motion abnormalities were more prevalent in men than women (all P &lt;.001). Of interest, 0.5% of men and 0.4% of women with neither clinical heart disease nor hypertension had LV segmental wall motion abnormalities, suggesting silent disease, compared with 26% of men and 10% of women in the clinical CHD group ( P &lt;.0001). Multivariate analyses revealed male sex and presence of clinical CHD (both P &lt;.001) to be independent predictors of LV akinesis or dyskinesis. Conclusions Significant baseline relations were detected between differences in sex, prevalent disease status, and echocardiographic measurements of LV mass and systolic function in the CHS cohort. Age was weakly associated with LV mass measurements and LV ejection fraction abnormalities. These relations should be considered in evaluating the preclinical and clinical effects of CHD risk factors in the elderly.
BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2
Authors: Danilo Perrotti, Vincenzo Cesi, Rossana Trotta, Clara Guerzoni, Giorgia Santilli, Kenneth Campbell, Angela Iervolino, Fabrizio Condorelli, Carlo Gambacorti-Passerini, Michael A. Caligiuri, Bruno Calabretta
Journal: Nature Genetics (2001)
Case 7-1962
Authors: Robert S. Shaw
Journal: New England Journal of Medicine (1962)

Presentation of Case First admission. A sixty-two-year-old woman entered the hospital because of peripheral vascular disease.She had a long history of intermittent claudication, and four years before entry a transmetatarsal amputation was performed because of arteriosclerotic gangrene of the right first toe. One year later she was admitted to another hospital because of an episode of "indigestion" and was treated for coronary thrombosis. One year before admission, because of occlusion of the left superficial femoral and popliteal arteries, with impending gangrene of the left first toe, a left-common-femoral-to-popliteal arterial-by-pass Dacron-Teflon graft was inserted, and an endarterectomy of the left . . .
Loperamide toxicity in a child after a single dose.
Authors: N A Minton, P G Smith
Journal: BMJ (1987)

towards treating end stage renal failure in more elderly people and those with underlying diseases such as diabetes, and the less skilled they will be in diagnosing chronic renal failure.These findings suggest that intraregional variation should be examined more closely, as the findings may have implications for the organisation of treatment for end stage renal failure in the National Health Service.We thank the strategic planning group, renal interest group, and clinical and scientific services directorate of North West Thames Regional Health Authority.We are also particularly grateful to Julie Kelly for her excellent secretarial help.
The Diagnosis of Multiple Sclerosis
Authors: Sid Gilman
Journal: JAMA (1981)

Multiple sclerosis is an acquired disease of the CNS, characterized by neuropathologic changes in the white matter of the brain and spinal cord in random and multiple sites.<sup>1</sup>The disease essentially never affects the peripheral nervous system. The neuropathologic changes consist of loss of the myelin covering of axons in the form of demyelinative plaques.<sup>2</sup>The sites frequently affected account for the characteristic symptoms and signs, with disease of the optic nerves and chiasm causing visual disturbances, involvement of the cerebellum leading to gait and limb ataxia, and spinal cord lesions causing limb paresthesias and weakness as well as urinary and sexual disturbances. Many other sites commonly are affected as well. The disease is known to occur at as young an age as 6 years and at as old an age as 65 years. The onset occurs most frequently, however, during the second and third decades of life.
Ordering antimicrobial agents for hospitalized patients
Authors: C. M. Kunin
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Establishment and characterization of αs1-casein–specific T-cell lines from patients allergic to cow’s milk: Unexpected higher frequency of CD8+ T-cell lines
Authors: Haruyo Nakajima, Satoshi Hachimuraa, Shinya Nishiwakia, Toshiyuki Katsuki, Naoki Shimojo, Akio Ametani, Yoichi Kohno, Shuichi Kaminogawa
Journal: Journal of Allergy and Clinical Immunology (1996)
IMPACT OF CONTRAST-INDUCED NEPHROPATHY IN THREE DIFFERENT DEFINITIONS ON LONG-TERM MORTALITY AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH AND WITHOUT CHRONIC KIDNEY DISEASE: INSIGHTS FROM CREDO-KYOTO REGISTRY
Authors: Mitsuru Abe, Ryoji Taniguchi, Natsuhiko Ehara, Masaharu Akao, Yutaka Furukawa, Takeshi Morimoto, Toru Kita, Takeshi Kimura, None for the CREDO-Kyoto Investigators
Journal: Journal of the American College of Cardiology (2010)
Abstract 4998: Down-regulation of Hsulf-1 promotes tumorigenicity of ovarian cancer cells
Authors: Xiaoping He, Tsuyoshi Ohta, Viji Shridhar
Journal: Cancer Research (2010)

Abstract Human Sulfatase1 enzyme (HSulf-1) is down-regulated in a majority of ovarian cancer cell lines and primary tumors, but the functional consequence of this downregulation remains unclear. Here, we showed that down-regulation of HSulf-1 by RNA interference in OV202 ovarian cancer cells resulted in an elevated level of phosphorylated AKT. Conversely, over-expression of HSulf-1 in SKOV3 ovarian cancer cells led to decreased phosphorylation of AKT. When cells were treated with CDDP, OV202 cells with knockdown of HSulf-1 displayed more resistance to drug-induced apoptosis, with IC50 value 3-fold higher than cells with non-targeting shRNA, while SKOV3 cells with overexpression of HSulf-1 were more sensitive to drug-induced apoptosis compared to the control cells. Moreover, knockdown of HSulf-1 also endowed ovarian cancer cells with increased resistance to detachment-induced apoptosis (anoikis). Cell proliferation assays revealed that knockdown of HSulf-1 significantly accelerated cell proliferation of ovarian cancer cells in vitro. Importantly, when cells were injected subcutaneously, 7 of 8 (87.5%) nude mice developed tumors with HSulf-1 knockdown cells within 2 weeks. However, none of the mice injected with nontargeted control transduced cells (control group) developed tumors. Four weeks after injection, 8 of 8 (100%) nude mice developed tumors with HSulf-1 down-regulated cells, while only 2 of 5 (40%) mice had tumors in the control group. The average tumor weight was 4.2±2.7g per mice in HSulf-1 knockdown group, significantly higher than 0.6±0.3g per mice in the control group. Collectively, these results strongly suggest that down-regulation of HSulf-1 promotes tumorigenicity of ovarian cancer possibly due to elevated activation of AKT pathway. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4998.
Mothers are the key to reducing future inequalities in health
Authors: J. Wise
Journal: BMJ (1998)

The government should focus on improving the health of present and future mothers to reduce future inequalities in health, according to the forthcoming independent inquiry on inequalities in health, which is expected to be published in November.

Sir Donald Acheson, who was commissioned to chair the inquiry just over a year ago as part of the government's new health strategy, Our Healthier Nation , gave the first public account of the inquiry in his Harveian oration to the Royal College of Physicians last week. He said: “There is evidence that inequalities which we …
Cellular infiltration of the airways in asthma of varying severity.
Authors: M Synek, R Beasley, A J Frew, D Goulding, L Holloway, F C Lampe, W R Roche, S T Holgate
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

We have tested the hypothesis that airway infiltration by inflammatory cells reflects the severity of asthma by comparing the inflammatory cell infiltrates in fatal severe asthma and in subjects with mild to moderate asthma who died of unrelated causes. Sections of lung tissue from 25 fatal asthma cases and eight asthmatics who died of unrelated causes were immunostained by monoclonal antibodies (mAbs) using streptavidin-biotin peroxidase technique. The following cells were identified: mast cells (AA1:tryptase), eosinophils (EG1:stored cationic protein and EG2: secretory form of cationic protein), monocytes/macrophages (CD68), neutrophils (elastase), CD3+ and CD8+ T cells (CD3 polyclonal Ab and CD8+ mAb, respectively). Positive cells were counted in the epithelium and airway wall. The airways were divided into two groups: larger airways with internal perimeter (Pi) > 2 mm and smaller airways with Pi < 2 mm. All airways together were studied first, followed by larger and smaller airways examined separately. The numbers of intraepithelial CD3+ T cells were significantly lower in fatal asthma than in mild-moderate asthma both when all airways were considered (0.35 versus 0.86 cells/mm, p = 0.034) and in the larger airways alone (0.08 versus 1.05 cells/mm, p = 0.039). The numbers of EG1- and EG2-positive eosinophils infiltrating the airway wall of the larger airways were greater in fatal asthma than in mild-moderate asthma (78.2 versus 22.8 cells/mm2, p = 0.012 and 138.1 versus 31.7 cells/mm2, p = 0.022). In the smaller airways no significant difference was found between the two groups. We conclude that in fatal asthma there is a redistribution of CD3+ T cells away from the epithelium and proximal enhancement of the eosinophil inflammatory infiltrate. These findings have implications for the pathophysiology of asthma that results in death.
Cholesterol, Atherosclerosis, Ischemic Heart Disease, and Stroke
Authors: SEYMOUR DAYTON
Journal: Annals of Internal Medicine (1970)

Prospective epidemiologic studies have uniformly demonstrated that a high serum cholesterol level is predictive of increased risk of myocardial infarction or sudden death, but a relationship between cholesterol level and cerebral stroke has not been consistently found. Lowering of serum cholesterol concentrations may retard atherogenesis and delay some of its complications. A controlled clinical trial of a cholesterol-lowering diet in older men has resulted in a decreased combined incidence of myocardial infarction, sudden death, and cerebral infarction; the diet was more effective if started before age 66. Even though efforts to lower plasma cholesterol by pharmacologic inhibition of cholesterol biosynthesis have yielded discouraging results, there are sound reasons to attempt a new approach by inhibition of hepatic prenyl synthetase, the enzyme that catalyzes synthesis of farnesyl pyrophosphate.