tbuckley/cabot-search huggingface dataset:
A Study of the Interrelations of Rheumatoid Arthritis and Diabetes Mellitus
Authors: K. A. J. Jarvinen
Journal: Annals of the Rheumatic Diseases (1950)

In investigations on the interrelations of rheumatoid arthritis and the various endocrine disturbances, very little attention has been paid to diabetes mellitus.Thus, there exist only short notes on the occurrence of rheumatoid arthritis among diabetics (Wolf, 1936), and only the effects of an insulin treatment given to rheumatoid arthritis patients have been subjected to a closer examination (Copeman, 1946).A further reason for analysing the interrelations of rheumatoid arthritis and diabetes mellitus was that an increased secretion of the adrenocortical gluco- corticoids (as cortisone or Compound E) and of the antehypophyseal hormones (ACTH) is at present regarded as a feature of diabetes mellitus; and these hormones are those upon which the interest in rheumatoid arthritis is now concentrating.MaterialThe study comprises the rheumatoid arthritis and diabetes mellitus patients treated at the Third Medical Clinic of the University of Helsinki and in the medical wards of the Kivela Hospital during the 15-year period 1934-1948.Rheumatoid Arthritis Patients.-Therewere 1,008 in this group, of whom 725 were female and 283 male.The average age in the whole group was 48-7 years.Diabetes Mellitus Patients.-Therewere 766 altogether, of whom 490 were female and 276 male.The average age was 51 -6 years. Rheumatoid Arthritis and Diabetes Mellitus occurringin the same PatientIn the present series, 1 -3±0*36 per cent. of the rheumatoid arthritis patients were affected with diabetes mellitus, and 1*7±0*47 per cent. of the diabetes mellitus group suffered from rheumatoid arthritis.In order to know whether the present results show that these two diseases have a tendency either to occur together more often than is due to pure chance, or to avoid each other, the figures should be compared with the corresponding morbidity rates among similar population groups.According to earlier studies (Jarvinen, 1950) the frequency of rheumatoid arthritis in Helsinki is 0 94±0 35 per cent. in control material, corresponding in sex distribution with the diabetes group in question.However, the average age in this control group was only 36 years.In view of the studies of the age distribution 226 copyright.
Tc-99m LABELED ANTI-GRANULOCYTE ANTIBODY (AGA): PHARMACOKINETICS AND RADIATION DOSIMETRY
Authors: S Vallabhajosula, C J Palestro, P Chau, H Lipszyc, A Szatkowski, S J Goldsmith
Journal: Clinical Nuclear Medicine (1992)

Vallabhaiosula, S.; Palestro, C. J.; Chau, P.; Lipszyc, H.; Szatkowski, A.; Goldsmith, S. J.Author Information
A boronate-linked linear-hyperbranched polymeric nanovehicle for pH-dependent tumor-targeted drug delivery
Authors: Hui-zhen Jia, Jun-yi Zhu, Xu-li Wang, Han Cheng, Gang Chen, Yi-fang Zhao, Xuan Zeng, Jun Feng, Xian-zheng Zhang, Ren-xi Zhuo
Journal: Biomaterials (2014)
SUCCESSFUL OPERATION ON A STRANGULATED HERNIA OF THREE DAYS' DURATION UPON A MAN, 76 YEARS OLD, HAVING PARALYSIS OF THE LEFT SIDE.
Authors: ROBERT ANDREW KITTO
Journal: JAMA (1892)

Mr. Christian G. aged 76; Danish. Paralyzed on the entire left half of his body. The patient had a severe fit of sneezing, which was followed by protrusion of the gut through both rings into the scrotum. Family physician was called on the evening of the second day after the accident. He found the gut strangulated, and all efforts at reduction proved futile. Consultation was had, with the result that nothing could be done for him in consequence of his age and infirmity. I was asked to see the case, which was the evening of the third day following the accident, when I attempted to reduce the tumor under an anæsthetic, which proved to be impossible. Anxious relatives urged that something in the way of an operation be done to reduce his suffering. I agreed with them, and consented to operate at once. I called three assistants, and after a
Neutrophil elastase inhibitor ICI 200,880 protects against attenuation of coronary flow reserve and myocardial dysfunction following temporary coronary artery occlusion in the dog
Authors: J L Mehta, W W Nichols, F A Nicolini, J Hendricks, W H Donnelly, T G P Saldeen
Journal: Cardiovascular Research (1994)

Objective: Diminished coronary flow reserve and myocardial dysfunction following coronary artery occlusion and reperfusion have been attributed to neutrophil infiltration into the reperfused regions. Release of free radicals and elastase during reperfusion may also contribute to ischaemia-reperfusion induced changes. The aim of this study was to determine the effect of an elastase inhibitor on reperfusion induced attenuated coronary flow reserve and myocardial dysfunction. Methods: Anaesthetised dogs were subjected to 1 h of left anterior descending coronary artery occlusion and 2 h of reperfusion. Ten minutes before reperfusion, dogs were randomly given saline or the neutrophil elastase inhibitor ICI 200,880 (10 mg·kg−1) and treatment was continued for the next 70 min. While the regional myocardial shortening fraction and coronary blood flow responses to acetylcholine and glyceryl trinitrate were attenuated following coronary reperfusion in saline treated dogs, similar reductions were not observed in the ICI 200,880 treated dogs (p < 0.01). Histopathology showed myocardial injury and extensive neutrophil infiltration in the reperfused regions in saline treated animals. In contrast, neutrophil infiltration was minimal in the ICI 200,880 treated dogs, in spite of myocardial injury. Myeloperoxidase, an index of neutrophil infiltration, was increased (p < 0.02 v control regions) in the reperfused regions in saline treated dogs, but not in the ICI 200,880 treated dogs. Flow cytometry also showed diminished neutrophil infiltration and oxidative burst in reperfused myocardium of ICI 200,880 treated (v saline treated) dogs. Conclusions: The elastase inhibitor ICI 200,880 protects against ischaemia-reperfusion induced attenuated coronary flow reserve and myocardial dysfunction, and this protective effect is associated with decreased neutrophil infiltration into the reperfused regions.
Diffuse reticulum cell sarcoma of the gastrointestinal tract: a problem in diagnosis.
Authors: K W Heaton, J S Cornes, A E Read
Journal: Gut (1966)

EDITORIAL SYNOPSiS This unusual case extends the differential diagnosis of diffuse intestinal lesions by showing that reticuloses may present in this way.The reticuloses or malignant lymphomas sometimes involve the gastrointestinal tract.The disease is then usually confined to one portion of the gut, particularly the stomach or the ileum (Allen, Donaldson, Sniffen and Goodale, 1954;Skrimshire, 1955).In the case reported here the lymphoma extended continu- ously from the stomach to the rectum.The resulting radiological appearances produced great diagnostic difficulty. CASE REPORTThe patient, a woman aged 50 years, presented in May 1965 with a two-month history of diarrhoea and lower abdominal pain.She had lost two or three pounds in weight but had a good appetite and did not feel unwell.The only important past illness was pulmonary tuberculo- sis in 1945 from which she had made a good recovery.Examination showed a fit-looking, slightly built woman.There was no lymphadenopathy and the heart and lungs were clinically normal.Palpation of the abdo- men was difficult but there seemed to be an ill-defined mass on the right side.Rectal examination revealed only third-degree haemorrhoids.Sigmoidoscopy was normal.FIG. 1. Barium enema, showing irregular narrowing ofthe colon with loss of haustration.453
Genetic Counseling in Oncology
Authors: A. H. Buchanan, J. E. Stopfer
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Muscle fiber characteristics in postmenopausal women with normal or impaired glucose tolerance.
Authors: H Larsson, J R Daugaard, B Kiens, E A Richter, B Ahrén
Journal: Diabetes Care (1999)

OBJECTIVE: Muscle fiber characteristics are altered in type 2 diabetes. We studied whether these alterations also exist in impaired glucose tolerance (IGT) and whether they are determinants of insulin sensitivity and glucose tolerance in postmenopausal women. RESEARCH DESIGN AND METHODS: Percutaneous muscle biopsies from the vastus lateralis muscle were obtained from 77 postmenopausal women aged 57-59 years: 50 women with normal glucose tolerance (NGT) and 27 with IGT. The IGT group had a reduced insulin sensitivity compared with the NGT group (euglycemic-hyperinsulinemic clamp) (P = 0.003). RESULTS: The groups did not differ in muscle fiber composition, as judged by the percentage of type I, IIa, or IIx fibers. In contrast, the IGT group had increased size of the IIa (mean +/-SD 3,776+/-987 vs. 3,078+/-862 microm2, P = 0.002) and IIx fibers (2,730+/-1,037 vs. 2,253+/-672 microm2, P = 0.017). There was a trend for the capillary diffusion areas (the muscle area supplied by each capillary) to be larger in the IGT group for the IIa (1,132+/-286 vs. 1,013+/-240 microm2, P = 0.061) and IIx fibers (1,020+/-246 vs. 906+/-240 microm2, P = 0.058). In the entire group, insulin sensitivity correlated with the size of the type IIa fibers (r = -0.28, P = 0.013), but not with the percentages of muscle fiber types. In a multiple regression, insulin sensitivity was determined by body fat content and HDL cholesterol level, while the size of the IIa fibers was not included in the model. Glucose tolerance was independently predicted by the number of capillaries/type I fiber, as well as by insulin sensitivity and triglyceride levels. CONCLUSIONS: We conclude that although muscle fiber composition is not altered, women with IGT have larger type IIa and IIx muscle fibers and a trend for increased capillary diffusion areas for these fibers, compared with women with NGT. In the entire group, insulin sensitivity was determined mainly by body fat content, while muscle fiber capillarization may be of importance for glucose tolerance.
Vesico-colic Fistula
Authors: KOTTEK KATTU BALAN, MAIR CRITCHLEY
Journal: Clinical Nuclear Medicine (1997)

A 65-year-old man, who had a history of weight loss and frequent urinary tract infections, had carcinoma of the colon. He underwent a bone scan to exclude skeletal metastasis. The images performed at 3 hours did not show any evidence of bony lesion, but they did show activity in the large bowel continuous with the activity in the bladder, suggesting the presence of a vesicocolic fistula.
Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS).
Authors: D E Mosier, R A Yetter, H C Morse
Journal: The Journal of Experimental Medicine (1987)

Athymic nu/nu mice were found to be resistant to the immunodeficiency disease and lethality induced in normal mice by the injection of the LP-BM5 mixture of murine retroviruses (LP-BM5 MuLV). Susceptibility to disease induction was reconstituted by injection of nu/nu mice with purified, mature T lymphocytes. The extent of viral replication of both the ecotropic and mink cell focus forming (MCF) components of LP-BM5 MuLV was equivalent in both nu/nu and normal animals. Retrovirally-induced immunodeficiency disease in mice (MAIDS) is thus dependent upon the presence of functional T lymphocytes, and high virus titers in athymic mice have little or no effect on the immune system.
Tuberculosis and tumour necrosis factor-α inhibitor therapy: a report of three cases in patients with psoriasis. Comprehensive screening and therapeutic guidelines for clinicians
Authors: A. Perlmutter, A. Mittal, A. Menter
Journal: British Journal of Dermatology (2008)

Tumour necrosis factor (TNF)-alpha inhibitors, long used in rheumatology and gastroenterology, have made a significant impact on the therapy of psoriasis and psoriatic arthritis. TNF-alpha is an important cytokine in normal physiological processes such as the immune response to granulomatous infection. Inhibition of this process by TNF-alpha inhibitors has been reported to increase the susceptibility of patients to granulomatous infections such as Mycobacterium tuberculosis. Despite the numerous reported cases in the literature and appropriate warnings on the labels for the three currently approved TNF-alpha inhibitors, current guidelines do not address case-specific issues across the full spectrum of tuberculosis. The probability of developing active tuberculosis has been reported to be as much as seven times higher when recommendations are not followed. We report three cases of tuberculosis induced by TNF-alpha inhibitors despite a rigorous screening policy in our tertiary care psoriasis centre, and suggest tuberculosis-specific guidelines for clinicians using these agents based on a review of the literature.
Progressive Personality Changes and Hemiparesis in a Middle-aged Man
Authors: Robert G. Feldman
Journal: JAMA (1973)

<h3>Dr. Tarsy:</h3> A 46-year-old, right-handed drawbridge operator was admitted to the Boston Veterans Administration Hospital on July 27, 1970, because of personality changes of six months' duration and mild left hemiparesis of three months' duration. Six months earlier, he had had several minor automobile accidents, which were apparently due to inattention. In addition, because of repeated errors, one month prior to admission he had been forced to resubmit reports detailing ship passages beneath the drawbridge he operated. The patient's family had noted a decline in motivation; he became irritable as well and oblivious to criticism concerning his behavior. On the day of admission, he urinated against the front wall of the hospital. There was no history of memory loss, geographic disorientation, or difficulty with speech, but he did have a three-month history of drooping of the left corner of his mouth and diminished dexterity in his left hand.
Finally! A human pancreatic β cell line
Authors: Gordon C. Weir, Susan Bonner-Weir
Journal: Journal of Clinical Investigation (2011)

For decades, investigators have made numerous attempts to generate human pancreatic β cell lines that could be used to advance β cell biology, facilitate drug discovery, and provide a pathway to β cell replacement therapy for the treatment of diabetes. In this issue of the JCI, Ravassard and colleagues report that this has finally been achieved successfully with a multistep process that led to the generation of cells, which they termed EndoC-βH1 cells, that secreted insulin in response to glucose challenge.
LATE GADOLINIUM ENHANCEMENT AND ADVERSE CARDIAC EVENTS AT 1 YEAR FOLLOW-UP IN WOMEN WITH SIGNS AND SYMPTOMS OF ISCHEMIA AND NO OBSTRUCTIVE CORONARY DISEASE: A REPORT FROM THE WOMEN’S ISCHEMIA SYNDROME EVALUATION
Authors: Janet Wei, May Bakir, Louise Thomson, John Petersen, Quanlin Li, Erika Jones, Puja Mehta, Chrisandra Shufelt, Daniel Berman, Sheryl Kelsey, Eileen Handberg, George Sopko, Carl Pepine, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2015)
General practice records.
Authors: N M Maclean
Journal: BMJ (1978)

tricyclic and, if that should fail, of an MAO inhibitor.I have been impressed with the good response of about half of these very severely affected patients to such therapy.Elithorn' stated that migraine is "undeniably a hunting-ground for the drug-happy physician."This, of course, is true, but such a statement should not deter efforts to find an effective treatment for this distressing and persistent disorder.
Gamete intrafallopian transfer in older women: effect of limiting number of gametes transferred
Authors: C J Redgment, T Al-Shawaf, J G Grudzinskas, I L Craft
Journal: BMJ (1994)

The Human Fertilisation and Embryology Authority and its predecessors have restricted the maximum number of oocytes and embryos that can be transferred in gamete intrafallopian transfer and in vitro fertilisation to minimise the risk of multiple pregnancy. The current maximum of three practically eliminates the risk of quadruplet or higher order pregnancies.

Women in their fifth decade have reduced fecundity and an increased risk of miscarriage after spontaneous or assisted conception.1, 2 Because of this and the current restrictions we are concerned that such women might use donor oocytes from young women to overcome infertility, although they might have an acceptable chance of pregnancy if a flexible number of their own oocytes could be used. We therefore retrospectively assessed the effect of the restrictions on the outcome of gamete intrafallopian …
LICENSING OF FOREIGN MEDICAL GRADUATES IN THE UNITED STATES
Authors: CREIGHTON BARKER
Journal: JAMA (1949)

The licensing of graduates of European and other foreign medical schools, except those in Canada, has been a matter of grave concern to examining boards in a majority of our states for the last ten or a dozen years. Prior to that time, the number of graduates of foreign schools seeking settlement in this country was small, and often the candidates were of such unusual attainment that their coming here presented little question. However, coincidental with political changes in central Europe during the thirties, a substantial number of emigre physicians sought refuge in America, and licensing boards were faced with a new and complicated problem. At about the same time many American students went to Europe for medical education and returned here to practice. The Council on Medical Education of the American Medical Association has reported that from 1930 through 1947, 14,520 graduates of foreign schools, not including Canadian, were
Emerging therapies for food allergy
Authors: Corinne A. Keet, Robert A. Wood
Journal: Journal of Clinical Investigation (2014)

Food allergy is a common condition for which there are currently no approved treatments except avoidance of the allergenic food and treatment of accidental reactions. There are several potential treatments that are under active investigation in animal and human studies, but it is not yet clear what the best approach may be. Here, we review approaches that are currently in clinical trials, including oral, sublingual, and epicutaneous immunotherapy, immunotherapy combined with anti-IgE, and Chinese herbal medicine as well as approaches that are in preclinical or early clinical investigation, including modified protein immunotherapy, adjuvants, DNA vaccines, and helminth administration. We discuss the importance of fully exploring the risks and benefits of any treatment before it is taken to general clinical practice and the need for clarity about the goals of treatment.
The Hospital Bill That Medicare Won't Pay
Authors: Donald J. Dalessio
Journal: JAMA (1975)

FOR SOME time now, the intermediaries who administer Medicare have been sending notices to patients for whom payment for hospital services has been denied. It is their practice to send a mimeographed letter, unmodified and impersonal, no matter what the reason for the denial. An excerpt from that letter follows: Medicare will cover inpatient hospital services when the patient requires treatment or necessary diagnostic studies and these services can be furnished appropriately only while in the hospital. Since the services you received do not meet this requirement, no hospital insurance benefits can be paid for your stay. A determination has been made that you had no knowledge nor any way of knowing that the services you received during this stay were not medically necessary. However, the records show that this hospital knew or should have known that such a service would be considered non-covered. It has therefore been determined that
Public Attitudes and Perceptions About Health-Related Research
Authors: Mary Woolley, Stacie M. Propst
Journal: JAMA (2005)

Health-related research in the United States is funded by US citizens, either as taxpayers or as consumers. Public support is critical to the success of the research enterprise, and it is essential for stakeholders in research to pay attention to the public's views about the investment level in research and the nature of its conduct, as well as to understand the public's level of awareness and opinions about research to improve health. This article reviews key results from surveys concerning public attitudes and perceptions toward health-related research. Collectively, these data demonstrate that Americans rate research as a high national priority, and they strongly support greater investment by public and private funders.
Maximum Urine Concentration
Authors: B. E. Miles, A. Paton, H. E. de Wardener
Journal: BMJ (1954)

in the pulmonary area was split and there was a systolic murmur (grade 3) at the apex.The Kahn test was negative.X-ray examination showed general cardiac enlargement with no particular enlargement of the left auiicle.The liver section showed the changes of passive congestion only.E.C.G. showed auricular fibrillation and right bundle-branch block.Once again he responded to digitalis and mersalyl, and was discharged free from heart failure.
Bioassay of Thyroid Stimulating Hormone Using the Goldfish
Authors: W. N. Hutton, C. J. Hayter
Journal: BMJ (1970)

A new method for the bioassay of thyroid stimulating hormone using goldfish is described. The technique can detect thyroid stimulating substances in euthyroid unconcentrated plasma. Early results show that the method compares well with other techniques. Some evidence has been obtained which suggests that in primary myxoedema there may be some impairment of the thyropituitary “servo-mechanism” in older patients.
CD45 Deficiency Caused by Uniparental Disomy, a Novel Cause of Severe Combined Immunodeficiency
Authors: J.L. Roberts, R.H. Buckley, B. Luo, J. Pei, A. Lapidus, S. Peri, Q. Wei, J. Shin, R.E. Parrott, R. Dunbrack, J.R. Testa, X. Zhong, D.L. Wiest
Journal: Journal of Allergy and Clinical Immunology (2012)
The Coronary Care Unit Profile and Outcomes: What Has Changed in the Last Decade?
Authors: İlknur Çalpar, Osman Şükrü Karaca, Ahmet Büyük, Cem Bostan, Ahmet Yıldız, Murat Kazım Ersanlı, Seçkin Pehlivanoğlu, Rasim Enar
Journal: Journal of the American College of Cardiology (2013)