Cisplatin, Vinblastine, and Bleomycin for Endodermal Sinus Tumor of the Ovary
Authors: JULIAN L. LOKEY
Journal: Annals of Internal Medicine (1981)

Brief Reports1 January 1981Cisplatin, Vinblastine, and Bleomycin for Endodermal Sinus Tumor of the OvaryJULIAN L. LOKEY, M.D., J. JAY BAKER, M.D., NORMA A. PRICE, M.D., STANLEY H. WINOKUR, M.D.JULIAN L. LOKEY, M.D.Search for more papers by this author, J. JAY BAKER, M.D.Search for more papers by this author, NORMA A. PRICE, M.D.Search for more papers by this author, STANLEY H. WINOKUR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-1-56 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEndodermal sinus tumor of the ovary is a malignant germ cell neoplasm affecting young women and children that historically has been associated with an extremely poor prognosis. Surgery alone or in combination with radiation therapy has resulted in a 3-year actuarial survival of 13% (1). Postoperative combination chemotherapy has resulted in improved survivals (2-5). We report here preliminary results using cisplatin, vinblastine, and bleomycin (PVB) in two patients after unilateral salpingo-oophorectomy for stage Ia disease.Patient 1, a 28-year-old white woman, developed severe abdominal pain in the immediate postpartum period. Computerized axial tomography demonstrated a large abdominal mass. Laparotomy (26...References1. KURMANNORRIS RH. Endodermal sinus tumor of the ovary: a clinical and pathologic analysis of 71 cases. Cancer. 1976;84:2404-19. CrossrefGoogle Scholar2. SMITHRUTLEDGE JF. Advances in chemotherapy for gynecologic cancer. Cancer. 1975;36:669-74. CrossrefMedlineGoogle Scholar3. SLAYTONHRESHCHYSHYNSILVERBERG RMS. Treatment of malignant ovarian germ cell tumors: response to vincristine, actinomycin, and cyclophosphamide (preliminary report). Cancer. 1978;42:390-8. CrossrefMedlineGoogle Scholar4. FORNEYDISAIAMORROW JPC. Endodermal sinus tumor: a report of two sustained remissions treated postoperatively with a combination of actinomycin-D, 5-fluorouracil and cyclophosphamide. Obstet Gynecol. 1975;45:186-9. MedlineGoogle Scholar5. CANGIRSMITHVANEYS AJJ. Improved prognosis in children with ovarian cancers following modified VAC (vincristine sulfate, dactinomycin, and cyclophosphamide) chemotherapy. Cancer. 1978;42:1234-8. CrossrefMedlineGoogle Scholar6. SELLSOGAARDNORGAARD-PEDERSEN AHB. Serum alpha-fetoprotein as a marker for the effect of postoperative radiation therapy and/or chemotherapy in eight cases of ovarian endodermal sinus tumor. Int J Cancer. 1976;18:574-80. CrossrefMedlineGoogle Scholar7. EINHORNDONOHUE LJ. Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med. 1977;87:293-8. LinkGoogle Scholar8. NEIDHARDTMEMOMETZWISE JREH. Probable cure of advanced testicular cancers by intensive primary chemotherapy without maintenance. Proc Am Soc Clin Oncol. 1979;20:383 (C-382). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JULIAN L. LOKEY, M.D.; J. JAY BAKER, M.D.; NORMA A. PRICE, M.D.; STANLEY H. WINOKUR, M.D.Affiliations: Georgia Oncology Hematology Clinic Atlanta, Georgia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChemotherapy for malignant germ cell ovarian cancer in adult patients with early stage, advanced and recurrent diseaseCisplatin, Vinblastine and Bleomycin in Advanced and Relapsed Germ Cell Tumours of OvaryClinical Features and Management of Gynecologic Yolk Sac TumorsNondysgerminomatous tumors of the ovary treated with cisplatin, vinblastine, and bleomycin: Long-term resultsEndodermal sinus tumor of the ovary: A case series with flow cytometric DNA content analysisSuccessful therapy of metastatic embryonal carcinoma coexisting with gonadoblastoma in a patient with 46,XY pure gonadal dysgenesis (Swyer's syndrome)Delivery of a normal infant following cisplatin, vinblastine, and bleomycin (PVB) chemotherapy for malignant teratoma of the ovary during pregnancyAdjuvant chemotherapy in a pregnant patient with endodermal sinus tumor of the ovaryAggressive chemotherapy in endodermal sinus tumorLong-term survival after vinblastine, bleomycin, and cisplatin treatment in patients with germ cell tumors of the ovary: An updateChemotherapy of germ-cell ovarian tumours: First-line treatment with etoposide, bleomycin and cisplatin or carboplatinPregnancy following treatment of endodermal sinus tumor of the ovary with combination chemotherapy, including cis-platinumTreatment of malignant nondysgerminomatous germ cell tumors of the ovary with vinblastine, bleomycin, and cisplatinTreatment of malignant nondysgerminomatous germ cell tumors of the ovary with vincristine, dactinomycin, and cyclophosphamideThymic hyperplasia following successful chemotherapy. A report of two cases and review of the literatureVinblastine, bleomycin, and cisplatin in malignant germ cell tumors of the ovaryMalignant ovarian germ cell tumors: A review of thirty-six casesVincristine, dactinomycin, and cyclophosphamide in the treatment of malignant germ cell tumors of the ovary. A gynecologic oncology group study (a final report)Mediastinal germ cell tumors in childhoodModified VAB-3 combination chemotherapy of advanced and recurrent endodermal sinus tumors of the ovaryCisplatin, vinblastine, and bleomycin therapy of yolk sac (endodermal sinus) tumor of the ovaryMalignant germ cell tumors of the ovaryYolk Sac TumorEFFECTIVE TREATMENT OF MALIGNANT OVARIAN GERM-CELL TUMORS WITH CISPLATIN, VINBLASTINE, AND BLEOMYCIN (PVB)Extragonadal germ cell tumors of the head and neck region: Review of 16 casesCombination chemotherapy with cisplatin, vinblastine, and bleomycin for endodermal sinus tumor of the ovaryGerm Cell Tumors of the Ovary: Pathology, Behavior and TreatmentPulmonary Pseudotumours Following Chemotherapy for Endodermal Sinus Tumour of the Ovary 1 January 1981Volume 94, Issue 1Page: 56-57KeywordsAbdominal painChildrenCombination chemotherapyComputersGerm cellsLaparotomyOvariesRadiation therapySurgeryTomography ePublished: 1 December 2008 Issue Published: 1 January 1981 PDF downloadLoading ...