tbuckley/cabot-search huggingface dataset:
Vitamin D deficiency in elderly people.
Authors: C Nagant de Deuxchaisnes, J P Devogelaer
Journal: BMJ (1991)

to the new contract, I believe that it is important to acknowledge the impact of other improvements in the provision of primary care services.The improvement in the call system in Perth could be said to be the most significant change in service provision, which perhaps "kick started" the recent rise in coverage rates.Locally in South Glamorgan, where coverage is now 82%,' the increase in provision of cervical cytology in general practice started well before the new contract, aided by an improved call-recall scheme and the provision of improved training for practice nurses.In our practice we attributed coverage of over 80% in 1987 not only to the efficiency of the call system but also to the provision of a sensitive, flexible, and timely service.'Such qualities can more readily be provided in general practice than in a traditional cytology service based in a clinic.I do, however, concur with Dr Reid and col- leagues' comments about the need to modify the payment system.In particular I would strongly support the introduction of a "more extensive and graduated system of remuneration."This should provide improved rewards to those practices with high proportions of working class, immigrant, or mobile populations, where the task of improving coverage is most challenging and demands careful, sensitive, and time consuming work by the practice team.The present payment system often fails to reward such work, which requires diligent adherence to long established principles of primary care practice.
Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice
Authors: Bao Lu, Barbara J. Rutledge, Long Gu, Joseph Fiorillo, Nicholas W. Lukacs, Steven L. Kunkel, Robert North, Craig Gerard, Barrett J. Rollins
Journal: The Journal of Experimental Medicine (1998)

Monocyte chemoattractant protein 1 (MCP-1) is a CC chemokine that attracts monocytes, memory T lymphocytes, and natural killer cells. Because other chemokines have similar target cell specificities and because CCR2, a cloned MCP-1 receptor, binds other ligands, it has been uncertain whether MCP-1 plays a unique role in recruiting mononuclear cells in vivo. To address this question, we disrupted SCYA2 (the gene encoding MCP-1) and tested MCP-1–deficient mice in models of inflammation. Despite normal numbers of circulating leukocytes and resident macrophages, MCP-1−/− mice were specifically unable to recruit monocytes 72 h after intraperitoneal thioglycollate administration. Similarly, accumulation of F4/80+ monocytes in delayed-type hypersensitivity lesions was impaired, although the swelling response was normal. Development of secondary pulmonary granulomata in response to Schistosoma mansoni eggs was blunted in MCP-1−/− mice, as was expression of IL-4, IL-5, and interferon γ in splenocytes. In contrast, MCP-1−/− mice were indistinguishable from wild-type mice in their ability to clear Mycobacterium tuberculosis. Our data indicate that MCP-1 is uniquely essential for monocyte recruitment in several inflammatory models in vivo and influences expression of cytokines related to T helper responses.
Risks and Benefits of Phase 1 Oncology Trials, Revisited
Authors: Razelle Kurzrock, Robert S. Benjamin
Journal: New England Journal of Medicine (2005)

Cancer is the most common cause of death in the United States, with more than 500,000 people succumbing each year.1 Despite dramatic advances in the treatment of certain cancers, the vast majority of patients with metastases die from the cancer. These sobering facts have evoked an intensive and increasingly successful endeavor to unravel the mechanisms that drive the growth of cancer cells, an enterprise that has produced a large number of new drugs, especially agents aimed at particular molecules.Investigations of anticancer drugs follow a characteristic path: in vitro experiments are followed by studies in animals, and then there is . . .
Clinical examination, xeromammography, and fine-needle aspiration cytology in diagnosis of breast tumours.
Authors: J M Thomas, B M Fitzharris, W H Redding, J E Williams, P A Trott, T J Powles, H T Ford, J C Gazet
Journal: BMJ (1978)

The diagnostic accuracy of clinical examination, xeromammography, and fine-needle aspiration cytology was compared with definitive histological findings in 255 breast lumps excised during one year. When suitable aspirates were obtained for cytological examination the diagnostic accuracy of aspiration cytology was higher than clinical examination or xeromammography. A diagnostic accuracy of 99% was achieved when all three screening tests were in agreement. As well as confirming a clinical diagnosis of malignancy, cytology is useful in identifying malignancy when clinical findings suggest that the tumour is benign. The availability of accurate cytology has affected patient management in many ways. Xeromammography did not enhance the diagnostic accuracy of clinical examination and aspiration cytology in patients presenting with a breast lump and, as a procedure with potential hazard, the benefit of routine xeromammography is questionable when an efficient cytological service is available.
Topical tacrolimus in the treatment of symptomatic oral lichen planus: A series of 13 patients
Authors: Todd W. Rozycki, Roy S. Rogers, Mark R. Pittelkow, Marian T. McEvoy, Rokea A. el-Azhary, Alison J. Bruce, Joseph P. Fiore, Mark D.P. Davis
Journal: Journal of the American Academy of Dermatology (2002)
Abstract 1455: Novel role for the metastasis suppressor NM23-H1 in suppression of transendothelial migration toward CXCL12 gradient
Authors: Marián Novak, David M. Kaetzel
Journal: Cancer Research (2011)

Abstract Expression of the metastasis suppressor NM23-H1 is inversely correlated with the stage of tumor progression and metastasis in several leading malignancies including melanoma. Although multiple enzymatic activities and protein interactions have been described for this molecule, the precise mechanism by which NM23-H1 suppresses metastasis remains unknown. Metastasis of highly malignant cells toward their metastatic niche is facilitated by chemokine gradients which also guide specific populations of hematopoietic progenitor cells during their differentiation. One of the major homing factors for differentiating hematopoietic cells, as well as organospecific metastasis of melanoma cells is CXCL12 (SDF-1). Our previous in vivo tumor explant assays indicated that NM23-H1 suppresses dissemination of tumor cells from the primary site and their entry into or departure from circulation. Herein, we report that forced expression of NM23-H1 in the NM23-H1-deficient and highly invasive melanoma cell lines WM793 and 1205LU potently suppressed their ability to undergo transendothelial migration toward a CXCL12 gradient. Furthermore, we saw a dose-dependent increase in adhesion of NM23-H1 deficient cells to endothelia following the exposure to CXCL12, a process that was effectively blocked by forced expression of NM23-H1. We are currently investigating the molecular and signaling events triggered in melanoma models upon exposure to CXCL12 in order to determine the precise molecular mechanisms through which NM23-H1 disrupts CXCL12 mediated tumor cell dissemination. Our preliminary analysis of downstream signaling from the cognate receptor for CXCL12, CXCR4, indicate delayed kinetics of Akt phosphorylation in NM23-H1-expressing 1205LU cells as compared to their NM23-H1-deficient counterparts. Although NM23-H1 has been previously described as a negative regulator of the small GTPases Rac1 and Cdc42, their activation was unaffected by NM23-H1 status in 1205LU cells. These preliminary results suggest a novel role for NM23-H1 in regulating CXCL12 signaling in suppression of transendothelial migration, a critical step in melanoma metastasis Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1455. doi:10.1158/1538-7445.AM2011-1455
Does capsule endoscopy have a role in equivocal coeliac disease?
Authors: K. E. Evans, R. Sidhu, K. Drew, M. E. McAlindon, D. S. Sanders
Journal: Gut (2011)

<h3>Introduction</h3> Endomysial antibody (EMA) and tissue transglutaminase (tTG) antibody testing is used to investigate for coeliac disease. Demonstration of villous atrophy (VA) on small bowel biopsy in the presence of positive serology is considered the gold standard for diagnosis. Difficulty in diagnosis may arise for several reasons. A minority of patients with coeliac disease have antibody negative disease. Some patients with positive antibodies may have histological changes that fall short of VA (Marsh Grade 1 and 2 (MG1-2)). Finally, not all VA is caused by coeliac disease. The aim of this study was to assess the usefulness of capsule endoscopy (CE) in equivocal coeliac disease. <h3>Methods</h3> Data from all patients with equivocal coeliac disease who underwent CE between 2004 and 2010 in a tertiary gastroenterology department were analysed. Group 1: antibody negative VA; group 2: MG1-2; group 3: positive coeliac serology with normal duodenal biopsy; group 4: miscellaneous including strong family history, refusal of gastroscopy, and non- gastrointestinal presentation of probable coeliac disease. Demographic data, indication for CE, serology and histology were recorded. Videos were analysed by an experienced gastroenterologist blinded to the clinical data. Markers of coeliac disease such as scalloping, mosaic pattern and loss of folds were assessed. A diagnosis of coeliac disease was further supported by not only CE appearances but also combinations of HLA typing (DQ-2 or DQ-8), gluten challenge/response to a gluten free diet and in some cases repeat duodenal biopsy. <h3>Results</h3> 91 patients, 62 female, median age 47 years, (range 18–89 years) underwent CE. Indications were: coeliac serology negative VA (n=31), MG1-2 (n=25), positive coeliac serology with normal biopsy (n=8), miscellaneous (n=27).12/91 (13%) had features of coeliac disease on CE. In addition, there were 3 cases of Crohn9s disease (table 1). In patients with coeliac antibody negative VA CE secures a diagnosis of coeliac or Crohn9s in 9/31 (29%) significantly more than in other groups (p=0.0344). <h3>Conclusion</h3> CE may have a role in the assessment of patients with coeliac antibody negative villous atrophy. Its routine use is not supported in other causes of equivocal coeliac disease.
750. Coelectrotransfer to Spinal Cord of Three Plasmids Coding for Pain Killer Gene and Regulatory Factors of the Tetracycline-Inducible System To Achieve Tightly Regulated Expression, Inhibition of Thermal Hyperalgesia, and Mechanical Allodynia
Authors: Chung-Ren Lin, Chien-Cheug Liu, Yi-Shen Chen, H-T Huang
Journal: Molecular Therapy (2006)

We describe an approach employing intrathecal plasmid electrotransfer to deliver secretable forms beta-endorphin, which can produce profound and long lasting analgesia in neuropathic rats. A tetracycline-inducible system (Tet-On) composed of three plasmids coding, respectively, for the transgene, the tetracycline transcriptional activator rtTA, and the silencer tTS was employed. The regulation of beta-endorphin expression was first assessed in spinal neuronal culture, then we electrotranfected this plasmid into the spinal cord of mononeuropathic rats and evaluated the analgesic potential of this therapy in vivo by thermal and mechanical withdrawal latency. Intraperitoneal injections of doxycycline were made to elucidate the possible exogenous upregulation of transfected beta-endorphin gene expression in vivo. The levels of beta-endorphin were analysed by intrathecal microdialysis and RIA. We found that he expression of the transgene upon doxycycline stimulation was rapid, stable, and tightly regulated (no background expression) both in vitro and vivo. The beta-endorphin protein was secreted into CSF at a level of 45 pmol/L in dialysate, which was sufficient to inhibit neuropathic pain. In conclusion, we have shown that controllable expression of beta-endorphin can be obtained following intrathecal electrotransfer of a tetracycline-inducible, three-plasmid-based system. Beta-endorphin protein expression following intrathecal electrotransfer allweviates siatic nerve ligation-induced limb pain. Although physiological minute-to-minute beta-endorphin regulation may not be attained, this approach suffice as a sole or complementary treatment for chronic pain.
Training the female competitor: physiological aspects of fitness.
Authors: Y Koutedakis, N C Sharp
Journal: British Journal of Sports Medicine (1991)

No single parameter can disclose the state of physical fitness of elite female competitors.For such indi- viduals, fitness is a composite which varies markedly from one sport to another.It contains aspects of body size and composition, aerobic (general endurance) and anaerobic (local muscular endurance/speed) metabolism, together with aspects of muscle strength.Elements of joint mobility and dynamic balance may also be included.Thus, by obtaining regular laboratory data on key physiological parameters, areas of relative weakness may be detected and trained.In the current context, various compo- nents of fitness, their physiological assessment, and some comparative data are discussed.(V2, max), which correlate reasonably well with performance in endurance events, may rise to
Serum Lipids and Lipoproteins in Men after Myocardial Infarction compared with Representative Population Sample
Authors: ANDERS GUSTAFSON, DAG ELMFELDT, LARS WILHELMSEN, GÖSTA TIBBLIN
Journal: Circulation (1972)

A nonselected series of 229 postmyocardial infarction (MI) patients was studied for up to 2 years following hospitalization. Their lipoprotein patterns, serum cholesterol, and triglyceride values were compared to those of a random population sample of men at comparable ages. Hyperlipoproteinemia, cholesterol, and triglyceride elevations were more common in MI patients than in men in the random sample, occurring with greatest frequency in the younger patients. There was a trend toward higher mortality among patients with hyperlipoproteinemia. Types II A and B were very common in young patients. Serum cholesterol values were significantly higher in the youngest patients and serum triglycerides higher than in the controls in age groups ≦ 40, 46-50, and 51-55 years.
Measurement of lumbar spine motion in population studies.
Authors: I F Macrae, V Wright
Journal: Annals of the Rheumatic Diseases (1969)

Discussion.-PROF.I. M. Rorrr (Middlesex Hospital) suggested that any lymphocyte might become a "killer" if exposed to a non-specific stimulus such as an antigenantibody complex or aggrated gamma-globulin plus com- plement.DR. MACLENNAN agreed that this was a possible explanation.He produced experimental evidence which suggested that complement components were unlikely to play a significant part in his particular experiments.DR.M. K. JASANI (Horsham) asked if the increased cytotoxicity could be due to stimulation of lymphocytes by an antigen present in synovial fluid.DR. MACLENNAN thought that, in his series of experiments, this possibility could be excluded.
Contact Lenses Need Tender, Loving Care, Ophthalmologists Warn, or Infection May Result
Authors: Timothy F. Kirn
Journal: JAMA (1987)

THE RISE in number of<i>Acanthamoeba</i>keratitis cases appeared so suddenly that it took many ophthalmologists by surprise. The first case in the United States was reported in 1973 in a south Texas rancher. Then, between 1973 and 1984, 31 cases were reported, according to the Centers for Disease Control (CDC) in Atlanta (<i>MMWR</i>1986;35:405-408). And that figure does not include the recent cases being reported in this issue of<i>JAMA</i>. In these cases, contact lenses are the culprit. Ophthalmologists say that the convenience and comfort of soft contact lenses lead wearers to take them for granted and become lax in their care routines. Users may forget to take them out, or run water from the faucet on them when cleaning, or put a fallen contact in their mouth to moisten it before returning it to their eye. James McCulley, MD, chair of the Department of Ophthalmology, University of Texas
Curable Patient With Metastatic Colorectal Cancer: Balancing Effective Therapies and Toxicities
Authors: Katherine Van Loon, Alan P. Venook
Journal: Journal of Clinical Oncology (2014)

Article Tools ONCOLOGY GRAND ROUNDS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2013.53.5195 Journal of Clinical Oncology - published online before print February 10, 2014 PMID: 24516031 Curable Patient With Metastatic Colorectal Cancer: Balancing Effective Therapies and Toxicities Katherine Van LoonxKatherine Van LoonSearch for articles by this author , Alan P. VenookxAlan P. VenookSearch for articles by this author Show More Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA https://doi.org/10.1200/JCO.2013.53.5195 First Page Full Text PDF Figures and Tables © 2014 by American Society of Clinical Oncology
Supplementation with antioxidants and folinic acid for children with Down’s syndrome: randomised controlled trial
Authors: Jill M Ellis, Hooi Kuan Tan, Ruth E Gilbert, David P R Muller, William Henley, Robert Moy, Rachel Pumphrey, Cornelius Ani, Sarah Davies, Vanessa Edwards, Heather Green, Alison Salt, Stuart Logan
Journal: BMJ (2008)

<b>Objectives</b> To assess whether supplementation with antioxidants, folinic acid, or both improves the psychomotor and language development of children with Down’s syndrome. <b>Design</b> Randomised controlled trial with two by two factorial design. <b>Setting</b> Children living in the Midlands, Greater London, and the south west of England. <b>Participants</b> 156 infants aged under 7 months with trisomy 21. <b>Intervention</b> Daily oral supplementation with antioxidants (selenium 10 μg, zinc 5 mg, vitamin A 0.9 mg, vitamin E 100 mg, and vitamin C 50 mg), folinic acid (0.1 mg), antioxidants and folinic acid combined, or placebo. <b>Main outcome measures</b> Griffiths developmental quotient and an adapted MacArthur communicative development inventory 18 months after starting supplementation; biochemical markers in blood and urine at age 12 months. <b>Results</b> Children randomised to antioxidant supplements attained similar developmental outcomes to those without antioxidants (mean Griffiths developmental quotient 57.3 <i>v</i> 56.1; adjusted mean difference 1.2 points, 95% confidence interval −2.2 to 4.6). Comparison of children randomised to folinic acid supplements or no folinic acid also showed no significant differences in Griffiths developmental quotient (mean 57.6 <i>v</i> 55.9; adjusted mean difference 1.7, −1.7 to 5.1). No between group differences were seen in the mean numbers of words said or signed: for antioxidants versus none the ratio of means was 0.85 (95% confidence interval 0.6 to 1.2), and for folinic acid versus none it was 1.24 (0.87 to 1.77). No significant differences were found between any of the groups in the biochemical outcomes measured. Adjustment for potential confounders did not appreciably change the results. <b>Conclusions</b> This study provides no evidence to support the use of antioxidant or folinic acid supplements in children with Down’s syndrome. <b>Trial registration</b> Clinical trials NCT00378456.
CCR3-blocking antibody inhibits allergen-induced eosinophil recruitment in human skin xenografts from allergic patients
Authors: Olivier Fahy, Stephanie Senechal, Philippe Lassalle, Han Vorng, Monique Capron, Andrew F Walls, Alan R McEuen, Mark G Buckley, Qutayba A Hamid, Benoit Wallaert
Journal: Journal of Allergy and Clinical Immunology (2002)
A randomized study on Peg-interferon alfa-2a with or without ribavirin in liver transplant recipients with recurrent hepatitis C
Authors: Mario Angelico, Alessandra Petrolati, Raffaella Lionetti, Ilaria Lenci, Patrizia Burra, Maria Francesca Donato, Manuela Merli, Mario Strazzabosco, Giuseppe Tisone
Journal: Journal of Hepatology (2007)
Barbara Yvonne Wright
Authors: Geoff Brigden
Journal: BMJ (2007)

Professor of surgery who developed evidence based surgery and medical ethicsAlan Johnson rose rapidly through the ranks of academic surgery to become reader in surgery at Charing Cross Hospital in 1971, a post he held until moving to the chair in surgery in Sheffield in 1979.He combined excellence in surgical skills, sharp scientific aptitude, a rigorous approach to developing evidence based surgery, and a strong interest in medical ethics.He translated these interests into a body of published work which made an important contribution to the disciplines of gastroduodenal motility, hepatobiliary and upper gastrointestinal surgery, randomised surgical trials, and medical ethics.In total, he edited or authored 10 textbooks, over 35 book chapters, and almost 200 original publications.Two of his books were published after his retirement, including a text on surgical palliative care, and his last book, entitled Making Sense of Medical Ethics and written jointly with his son Paul, was completed a month before his death.He published prospective randomised trials evaluating the role of lithotripsy in the treatment of gallstones and a trial comparing laparoscopic with mini-and evaluated new techniques throughout his surgical career and latterly had been a pioneer in the surgical treatment of obesity.
TCT-754 Efficacy and Safety of Balloon Pulmonary Angioplasty for Peripheral Type Chronic Thromboembolic Pulmonary Hypertension
Authors: Yu Taniguchi, Noriaki Emoto, Hiroto Kinutani, Hiromasa Otake, Toshiro Shinke, Junya Shite, Kenichi Hirata
Journal: Journal of the American College of Cardiology (2012)
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
Authors: Katarzyna Mleczko-Sanecka, Guillem Casanovas, Anan Ragab, Katja Breitkopf, Alexandra Müller, Michael Boutros, Steven Dooley, Matthias W. Hentze, Martina U. Muckenthaler
Journal: Blood (2009)
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons
Authors: Hawon Cho, Young Duk Yang, Jesun Lee, Byeongjoon Lee, Tahnbee Kim, Yongwoo Jang, Seung Keun Back, Heung Sik Na, Brian D Harfe, Fan Wang, Ramin Raouf, John N Wood, Uhtaek Oh
Journal: Nature Neuroscience (2012)
Suppression of Lactation by Oral Oestrogen
Authors: G. L. Foss, P. Phillips
Journal: BMJ (1938)

ABORTUS INFECTION METHBRITISH 887 qlently five cases in one practitioner s practice must be considered most unusual.The age incidence is more or less in conformity with other people's findings.The sex incidence, however, is well worth noting: I had two males and three females, and another practitioner had one female-that is, four females and two males.Creed states