PROPHYLACTIC AND THERAPEUTIC DETOXICATION
Authors: GUSTAV J. MARTIN
Journal: Annals of Internal Medicine (1943)

Article1 January 1943PROPHYLACTIC AND THERAPEUTIC DETOXICATIONGUANIDINE, INDOLE AND HISTAMINE*GUSTAV J. MARTIN, E. H. RENNEBAUM, MARVIN R. THOMPSONGUSTAV J. MARTINSearch for more papers by this author, E. H. RENNEBAUMSearch for more papers by this author, MARVIN R. THOMPSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-1-57 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIndole, histamine and guanidine are representative examples of toxic chemicals produced endogenously. These compounds were considered as a group not only because of their endogenous origin but also because each is associated with diseases known to afflict the human body. No study of therapeutic and prophylactic detoxication would be complete without a consideration of these toxic metabolites. It is to be emphasized that each is a representative of a group of toxic substances and that there is a large number of additional groups of toxic metabolites.Histamine is formed through the action of putrefactive bacteria on histidine.1It has...Bibliography1. ACKERMANN D: Origin of bases in putrefaction, Ztschr. f. physiol. Chem., 1910, lx, 504. CrossrefGoogle Scholar2. HANKEKOESSLER MTKK: Studies of proteinogenous amines, Jr. Biol. Chem., 1924, lix, 879-889. CrossrefGoogle Scholar3. BEST CH: Disappearance of histamine from autolyzing lung tissue, Jr. Physiol., 1929, lxix, 256. CrossrefGoogle Scholar4. CANNON WB: Consideration of possible toxic and nervous factors in production of traumatic shock, Ann. Surg., 1934, c, 704. CrossrefGoogle Scholar5. BLALOCK A: Experimental shock, Arch. Surg., 1930, xx, 959. CrossrefGoogle Scholar6. MOONKENNEDY VHPJ: The pathology of shock, Arch. Path., 1932, xiv, 360. Google Scholar7. SPRIGGS E: Clinical study of headaches, Lancet, 1935, ii, 63. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIndolePhysiologische Chemie der Lebensvorgänge und OrganeThe Conjugates of D-Glucuronic Acid of Animal OriginThe Antitubercular Activity of D-Galacturonic Acid Isonicotinyl Hydrazone*THE PHARMACODYNAMICS OF HISTAMINEBIBLIOGRAPHYGeneral physical diagnosis 1 January 1943Volume 18, Issue 1Page: 57-71KeywordsBacteriaHistamineMetabolites ePublished: 1 December 2008 Issue Published: 1 January 1943 PDF downloadLoading ...