tbuckley/cabot-search huggingface dataset:
HOST GENETIC CONTROL OF RECOVERY FROM FRIEND LEUKEMIA VIRUS-INDUCED SPLENOMEGALY
Authors: Bruce Chesebro, Kathy Wehrly, Jack Stimpfling
Journal: The Journal of Experimental Medicine (1974)

The influence of the major mouse histocompatibility gene complex (H-2) on the response of mice to Friend leukemia virus was studied in F(1) congenic mice differing only at genes within the H-2 complex. F(1) mice which were H-2(b/b) had a high incidence of recovery from splenomegaly compared to H-2(b/d) or H-2(b/a) mice. In mice with recombinations within the H-2 complex a gene (designated RFV-1), responsible for the Friend virus recovery effect, was found to map near or within the D region of serologically detectable transplantation antigens. Because the incidence of recovery was much higher in F(1)H-2(b/b) mice than in parental H-2(b/b) mice, other non-H-2 host genetic factors also appear to be important to expression of recovery in H-2(b/b) F(1) mice. The mechanisms of action of these genes remain unknown.
All that glisters
Authors: M. E Black
Journal: BMJ (2009)

The doctor sat in front of a computer, concentrating hard as she considered how to explain a two year gap in her CV. Nothing unusual there, you might think. Many of us take career breaks, but this doctor’s illegal migration in search of a job in western Europe had gone badly wrong, and she had been trafficked and forced to have sex with 10 or more men a night while her young daughter waited without news in Moldova. I met her while helping organise entrepreneurship training for trafficked women in Belgrade. …
Differential irritant skin responses to topical retinoic acid and sodium lauryl sulphate: alone and in crossover design
Authors: I. EFFENDY, S. WELTFRIEND, S. PATIL, H. I. MAIBACH
Journal: British Journal of Dermatology (1996)

Topically applied all-trans retinoic acid (RA) is often associated with skin irritation. A detailed quantification of RA-induced functional changes in stratum corneum is, however, still limited. Using non-invasive bioengineering techniques of measurements of transepidermal water loss (TEWL), stratum corneum hydration and cutaneous blood flow (CBF), we quantified the irritant effects of 0.05% and 0.1% RA in ethanol on normal skin compared with 1% sodium lauryl sulphate (SLS) in water as a model irritant in a 24-h occlusive patch-test assay. Additionally, in order to document data possibly related to the mechanism of action, skin responses to both compounds applied in tandem was also investigated over 18 days. The extent of the irritant response to 0.05 and 0.1% RA, respectively, were similar, implying analogous irritation potency. While RA caused more intense scaling than SLS, other skin responses to RA were significantly weaker than those due to SLS. An increase in TEWL, on day 7, in RA-exposed sites indicates a secondary delayed impairment of the stratum corneum (SC) barrier. In a tandem-design assay, pretreatment with RA appeared to reduce the irritant effects of SLS on SC hydration and CBF. In contrast, pre-exposure to SLS showed a synergestic response in erythema, scaling and TEWL. Our results demonstrate that RA, like SLS, is capable of impairing SC water barrier function, which may be responsible, in part, for the irritation associated with its topical use. However, the distinctive biological responses to these compounds suggest a different mode of action of RA and SLS. In addition, the precise reason for the unique results observed in the tandem-design assays is not clear.
Detection of Intestinal Duplication on Tc-99m Pertechnetate Imaging
Authors: Ji-Gang Yang, Chun-Lin Li, Rui-Rui Hao, Lan-Fang Zou
Journal: Clinical Nuclear Medicine (2007)

An 8-year-old boy was hospitalized for recurrent painless bleeding. Tc-99m pertechnetate scintigraphy showed a peculiar pattern. At surgery, an interesting duplication with cystic dilatation and perforation was found. Tc-99m pertechnetate scintigraphy is used frequently to detect Meckel diverticulum in infants with lower gastrointestinal bleeding, because pertechnetate is concentrated actively by the gastric mucosa contained in some diverticula. Other conditions such as intestinal duplication with ectopic gastric mucosa also can be identified using this method.
“Right to die”: …but context of limited resources can be encountered in developed countries too
Authors: William O Tarnow-Mordi
Journal: BMJ (2005)

Right to die" Legal view of right to life and death could threaten philosophy of palliative careEditor-Grayling claims that the "right to life" means quite a rich life; withholding treatment with death as the result and giving treatment that causes death are indistinguishable; and death is the ultimate analgesic. 1 Grayling also implies that the double effect is widely abused.The EC Convention for the Protection of Human Rights and Fundamental Freedoms protects against intentional deprivation of life. 2 Quality of life is not mentioned, and terminating a life at a person's request is clearly not permitted."Right to life" is perhaps a "right not to be killed," in medicine, generally relating to survival and not assisted death.However, some interpret it as giving patients a right to cardiopulmonary resuscitation regardless of the clinical circumstances 3 ; extrapolation to all potential interventions at the life-death interface could have disastrous consequences for the medical profession.Patients obviously can wish for their life to be terminated without needing to explain why, and they arguably have a right to attempt suicide.However, a right to assisted dying equates to a right that somebody else will kill or help to kill them on request-very different from withholding treatment or the double effect.Withholding treatment relates to interventions unable to produce the desired benefit. 4 In palliative care withholding treatment does not directly cause death that arises from an irreversible and unsustainable pathological burden.And death without adequate analgesia is possibly the ultimate pain for everyone.Judicious use of analgesia is an essential part of good terminal care, and, in 15 years as a doctor, I have yet to see a death attributable to deliberate analgesic overdose by a doctor.Palliative care affirms life until the moment of death, regarding death from advanced incurable disease as a natural process. 5 It aims to relieve pain and other distressing symptoms, enhance remaining quality of life, and neither hasten nor postpone death.These human "death rights" should perhaps be protected by legislation.Ill-conceived legislative changes that take the right to life or the right to death beyond sensible limits or give certain doctors the right to kill on request could jeopardise palliative care.
EU working time directive will include the time doctors spend on call
Authors: R. Watson
Journal: BMJ (2003)

The hours doctors spend on call in hospitals—even if they are not treating patients—should be counted as part of their working time under European Union legislation, according to the top legal adviser to the European Court of Justice.

The advocate general, Mr Damaso Ruiz-Jarabo, gave his opinion in a case referred to the Luxembourg based court from Germany that could go a long way towards clarifying complex EU rules. Under European working time legislation …
Abstract LB-18: The Cullin 3 substrate adaptor DIP-2 mediates DAPK ubiquitination to control interferon responses
Authors: Che-Hung Shen, Yu-Ru Lee, Hsuan-Chung Ho, Wei-Chien Yuan, Chun-Hau Chen, Hsiu-Ming Shih, Ruey-Hwa Chen
Journal: Cancer Research (2010)

Abstract Death-associated protein kinase (DAPK) is a pro-apoptotic, calmodulin-regulated serine/threonine kinase and was originally identified based on its involvement in interferon- -induced cell death. Whether and how interferon-γ-signaling regulates the activity or expression of DAPK remains largely unexplored. In this study, we identify the BTB-Kelch protein DIP2 functions as a negative regulator of DAPK by potentiating the proteosomal degradation of DAPK. DIP2 binds DAPK and Cul3 via its Kelch repeats and BTB domain, respectively. The DIP2-Cul3-ROC1 E3 ligase complex promotes DAPK ubiquitination both in vivo and in vitro, and downregulation of endogenous DIP2 diminishes DAPK ubiquitination and biological functions. The DIP2-dependent DAPK ubiquitination is suppressed in cells receiving either interferon-α or interferon-γ, which induces an enrichment/sequestration of DIP2 in the PML nuclear bodies, thereby separating DIP2 from its substrate DAPK. Through disrupting the interaction of DAPK with its E3 ligase, interferon triggers the stabilization of pro-apoptotic DAPK, which contributes to the cell death-promoting function of interferon. This study not only identifies the DIP2-Cul3-ROC1 complex as an E3 ligase for DAPK ubiquitination, but also reveals the underlying mechanism of DAPK regulation by interferon. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-18.
Somatic Treatments in Psychiatry
Authors: Maurice A. Schiller
Journal: JAMA (1961)

This is really a third edition of the authors' previous volume<i>Shock Treatments, Psychosurgery and Other Somatic Treatments in Psychiatry</i>, last published in 1952. They consider this a new book because it opens with a new section of 118 pages devoted to pharmacotherapy. This runs the gamut of the phenothia<i>zines, Rauwolfia</i>alkaloids, other nonbarbituate tranquilizers, psychoanaleptic drugs, monoamine oxidase inhibitors, stimulant drugs, and psychomimetrics. This is an excellent encyclopedic summary of the literature on each drug, which includes the chemistry, physiological and pharmacological properties, clinical effects, psychological effects, dosage, indications, contraindications, side effects, and complications. The latter should be carefully studied because the side effects are numerous and many drugs potentiate others. Some are very toxic to the liver. For the more severe psychotic reactions, especially those depressions which do not respond to pharmacotherapy, the authors still advise the use of electric convulsive therapy. Complications of ECT are minimized.
Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-κB in AML carrying NPM1 mutations
Authors: D Cilloni, F Messa, V Rosso, F Arruga, I Defilippi, S Carturan, R Catalano, M Pautasso, C Panuzzo, P Nicoli, E Messa, A Morotti, I Iacobucci, G Martinelli, E Bracco, G Saglio
Journal: Leukemia (2008)
Vasculopathic Hepatotoxicity Associated With E-Ferol Syndrome in Low—Birth-Weight Infants
Authors: Kevin E. Bove
Journal: JAMA (1985)

A fatal syndrome characterized by progressive clinical deterioration with unexplained thrombocytopenia, renal dysfunction, cholestasis, and ascites developed in certain infants throughout the United States who had received E-Ferol, an intravenous vitamin E supplement. We reviewed the clinical course of all 36 infants from one (index) nursery who had received E-Ferol, which contains 25 units per milliliter of dl-alpha-tocopheryl acetate solubilized with 9% polysorbate 80 and 1% polysorbate 20. The syndrome was recognized in eight of the 36 infants; affected infants had a lower birth weight (less than 1,200 g) and had received a higher total dose of E-Ferol for longer periods than the unaffected cases. We reviewed autopsy-derived tissue from 20 infants (six from the index nursery and 14 from three other collaborating nurseries) who had received the intravenous vitamin E preparation in a reported dose of 25 to 137 units/kg/day for six to 45 days between October 1983 and March 1984. The hepatic histology in the affected cases indicated a progressive injury characterized initially by Kupffer cell exfoliation, central lobular accumulation of cellular debris, and centrally accentuated panlobular congestion. Prolonged exposure to E-Ferol was associated with progressive intralobular cholestasis, inflammation of hepatic venules, and extensive sinusoidal veno-occlusion by fibrosis. We propose that vasculocentric hepatotoxicity is the basis for the observed clinical syndrome that represents the cumulative effect of one or more of the constituents of E-Ferol.
The Sentinel Pile of Ball —Not Brodie
Authors: Richard Kelvin
Journal: JAMA (1968)

To the Editor:—  May I come to the rescue of your correspondent, Dr. Leon Banov, and also of your editor (200:331, 1967;203:56, 1968)?  The sentinel pile was not described by Sir Benjamin Brodie, and so it is not surprising that the 19th-century textbooks on rectal diseases make no mention of it in association with Brodie's name. The little torment was, however, described by Sir Charles Ball, professor of surgery at the University of Dublin. He first propounded his theory as to its causation in cases of fissure in his book,The Rectum and Anus: Their Diseases and Treatment. He repeated the substance of this theory in his next textbook,The Rectum, Its Diseases and Developmental Defects, published in 1908,1 mentioning in the preface that his previous book was now out of date and withdrawn from circulation. I have been unable to locate copies of either the first
Blindness due to the IgA variant of epidermolysis bullosa acquisita, and treatment with osteo-odonto-keratoprosthesis
Authors: N.H. Cox, M.A. Bearn, J. Herold, G. Ainsworth, C. Liu
Journal: British Journal of Dermatology (2007)

Conflicts of interest: none declared. Sir, We describe a woman who initially presented in 1994, at age 47 years, with numerous groups of blisters in an annular arrangement on the trunk, strongly suggestive of linear IgA disease (LAD). Biopsy with immunofluorescence confirmed intense linear dermoepidermal IgA deposition which was felt to support the diagnosis of LAD, although recent re‐evaluation using indirect immunofluorescence and salt‐split skin has shown that the binding of IgA is predominantly dermal, thus suggesting that she actually has IgA‐epidermolysis bullosa acquisita (IgA‐EBA). No cause or associated disease have become apparent over 12 years of follow‐up. Some therapeutic aspects of this patient were included in an earlier report of vitamin E prophylaxis for dapsone‐induced headache1 (her initial treatment was with dapsone) but her treatments and response are further documented here as they are remarkable for the lack of efficacy. Treatments (individually or in combination) have included dapsone (with vitamin E); sulfapyridine; numerous topical (including ocular, buccal and vaginal) and systemic (oral and pulsed intravenous) corticosteroids; emollients/lubricants; topical and oral antibiotics; ciclosporin; mycophenolate mofetil; cyclophosphamide; intravenous immunoglobulin (six courses of infusions, each 2 g kg−1 over 5 days); subconjunctival mitomycin C; and subcutaneous interferon alfa (3 MIU three times weekly). Azathioprine was suggested but refused. Interferon, used on the basis of a single report in a patient who also had hepatitis C,2 was the most effective agent but caused significant anaemia and had to be discontinued.
New guidance is launched to help doctors protect vulnerable adults
Authors: H. Mooney
Journal: BMJ (2011)

Doctors must take action to protect vulnerable adults and ensure that safeguards are put in place if they believe people are being abused or neglected, according to new guidance from the British Medical Association.

The toolkit—Safeguarding Vulnerable Adults—A Toolkit for GPs—highlights the obligation doctors have in protecting vulnerable adults. This includes identifying abusers, identifying systemic healthcare failures, and reporting poor performance by other healthcare professionals.

Commissioned by the Department of Health in response to the lack of clarity in an increasingly complex area the guidance stresses that safeguarding vulnerable adults must not be the same as …
Rediscovering monoamine oxidase inhibitors.
Authors: C. Bass, R. Kerwin
Journal: BMJ (1989)

be noted.Only with such detailed information will fair comparisons be possible.The real differences in surgical mortality that do exist between surgeons and centres may teach important lessons.One study compared mortality between a teaching hospital and its adjacent district hospital and led to a proper intensive care unit being provided in the district hospital. 14 The confidential inquiry into perioperative deaths emphasised the value of regular reviews of mortality for teaching and training and the importance of organisation.2Some types of surgery should undoubtedly be concentrated in fewer hands.The development of management protocols for procedures with a high mortality and the mandatory participation of senior medical and surgical staff is also inevitable. 15
Cancer organisation hits out at medical research funded by tobacco companies
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2006)

The Israel Cancer Association has called for an amendment to the World Health Organization's Framework Convention for Tobacco Control to bar the use of tobacco industry money for medical research. At present, no laws against such funding exist, but numerous institutions have voluntarily set restrictions, such as the US National Institutes of Health and cancer research organisations in Britain, South Africa, and Australia.

The association is asking for support for the idea from the nearly 120 countries that are sending delegates to Geneva in February for a meeting of those that ratified the framework convention. The association has proposed that Israel's health ministry instructs its delegates to raise such a proposal before WHO and has circulated …
Doctors needs tougher targets to reduce heart disease further, says watchdog
Authors: Z. Kmietowicz
Journal: BMJ (2009)

The healthcare watchdog is calling on GPs and primary care commissioners in England to increase their efforts to tackle heart disease and says there should be tougher targets for incentive payments.

A study by the Care Quality Commission on the performance of 8300 GP practices and 152 primary care trusts to cut deaths from heart disease and reduce inequalities found that death rates have fallen largely because of reductions in smoking and cholesterol levels.

The government has already met its target to cut total deaths among people under 75 by at least 40% by 2010 and is on track to meet …
Local synthesis of ϵ germline gene transcripts, IL-4, and IL-13 in allergic nasal mucosa after ex vivo allergen exposure
Authors: Lisa Cameron, Qutayba Hamid, Erin Wright, Yutaka Nakamura, Pota Christodoulopoulos, Shigeo Muro, Saul Frenkiel, François Lavigne, Stephen Durham, Hannah Gould
Journal: Journal of Allergy and Clinical Immunology (2000)
Applicants for senior medical positions in New Zealand
Authors: I. Powell
Journal: BMJ (1995)

EDITOR,—The New Zealand public health service is going through a process of rapid restructuring, and the employers of salaried senior medical staff are now known as crown health enterprises. Coupled with this change is New Zealand's unique industrial law. For example, there is no longer the lawful ability to negotiate national terms and conditions of employment, and what right employees have to …
751 The safety and efficacy of viramidine® plus pegylated interferon alpha-2B versus ribavirin plus pegylated interferon alpha-2B in therapy-naïve patients infected with HCV: Phase 3 results
Authors: Y. Benhamou, P. Pockros, M. Rodrieuez-Torres, S. Gordon, M. Shiffinan, Y. Lurie, N. Afdhal, K. Lamon, Y. Kim, B. Murphy
Journal: Journal of Hepatology (2006)
Defining early mycosis fungoides
Authors: Nicola Pimpinelli, Elise A. Olsen, Marco Santucci, Eric Vonderheid, Andreas C. Haeffner, Seth Stevens, Guenter Burg, Lorenzo Cerroni, Brigitte Dreno, Earl Glusac, Joan Guitart, Peter W. Heald, Werner Kempf, Robert Knobler, Stuart Lessin, Christian Sander, Bruce S. Smoller, Gladys Telang, Sean Whittaker, Keiji Iwatsuki, Erik Obitz, Masahiro Takigawa, Maria L. Turner, Gary S. Wood
Journal: Journal of the American Academy of Dermatology (2005)
Positron emission tomography and recovery following revascularization (PARR-1): the importance of scar and the development of a prediction rule for the degree of recovery of left ventricular function
Authors: Rob S.B Beanlands, Terrence D Ruddy, Robert A deKemp, Robert M Iwanochko, Geoffrey Coates, Michael Freeman, Claude Nahmias, Paul Hendry, Robert J Burns, Andre Lamy, Lynda Mickleborough, William Kostuk, Ernest Fallen, Graham Nichol
Journal: Journal of the American College of Cardiology (2002)
Representation of Psychosomatic Disturbances: Metaphor and Metonymy
Authors: Italo Carta, Massimo Clerici, Cecilia Pantò, Raffaele Papa, Carlo Lorenzo Cazzullo
Journal: Psychotherapy and Psychosomatics (1986)

The purpose of this study was to explore the expressive capacities of our psychosomatic patients. We invited them to represent their illness in a drawing through the design test. Following this, we investigated 43 patients affected with bronchial asthma, 30 patients affected with refractory massive obesity and compared them with a control group of 25 'normal' subjects (medical students in a situation where stress and anxiety were strongly suspected as they were awaiting to sit for an examination in the Medical School). The two patient groups showed quite relevant differences as to their own expressive modalities in the use of metaphor and metonymy, which are considered as the graphic representation means of the illness.