tbuckley/cabot-search huggingface dataset:
Endothelin receptor-A blockade decreases ventricular arrhythmias after myocardial infarction in rats
Authors: G BALTOGIANNIS, D TSALIKAKIS, A MITSI, K HATZISTERGOS, D ELAIOPOULOS, D FOTIADIS, Z KYRIAKIDES, T KOLETTIS
Journal: Cardiovascular Research (2005)

Endothelin-1 (ET-1) production increases during acute myocardial infarction (MI) and may contribute to the genesis of ventricular tachycardia (VT) and ventricular fibrillation (VF). However, the antiarrhythmic effects of ET-1 receptor blockade, examined shortly after MI, have been debated. In the present study, we examined the effects of such treatment on VT/VF during the first 24 h post-MI.Thirty-five Wistar rats (223+/-22 g) were randomly allocated to either the ET-1 receptor-A (ETA) antagonist BQ-123 (0.4 mg/kg, BQ-123 group, n=17), or normal saline (control group, n=18) and were subjected to coronary artery ligation. A single-lead electrocardiogram was continuously recorded for 24 h post-MI, using an implanted telemetry system, and episodes of VT/VF were analyzed. Monophasic action potential (MAP) recordings were obtained from the left (LV) and right (RV) ventricular epicardium at baseline, 5 min after treatment and 24 h post-MI.There were 15.94+/-19.35 episodes/h/rat of VT/VF in the control group and 1.66+/-2.22 in the BQ-123 group (p=0.010), resulting in a lower (p=0.030) arrhythmic mortality in treated animals. The mean episode duration was 7.40+/-7.16 s for the control group and 2.30+/-1.37 s for the BQ-123 group (p=0.011). The maximum decrease in VT/VF was observed during the 1st, 5th and 6th hours post-MI. In the control group, LV MAP duration increased 24 h post-MI, displaying an increased beat-to-beat variation, but remained unchanged in the BQ-123 group.Acute ETA blockade reduces the incidence of VT/V F during the first 24-h post-MI in the rat, through a decrease in the dispersion of repolarization.
Seven NHS regional directors appointed
Authors: L Beecham
Journal: BMJ (1994)

Seven of the eight regional directors who will head the NHS regional offices in England from 1 April have been appointed. The offices will replace the six existing management outposts and the 14 regional health authorities, which will be abolished in April 1996 (30 October 1993, p 1091).

Northern and Yorkshire: Professor Liam Donaldson, currently regional general manager and director of public health, Northern Regional Health Authority (RHA).

North West: Mr Robert Tinston, currently chief executive, Mersey RHA.

West Midlands: Mr Brian Edwards, currently chief executive, West Midlands RHA.

Trent: Mr Keith McLean, currently regional general manager, Yorkshire RHA.

Anglia and Oxford: Ms Barbara Stocking, currently chief executive, Oxford RHA.

North Thames: Mr Ronald Kerr, currently regional general manager, North West Thames RHA.

South Thames: Mr Chris Spry, currently chief executive, South West Thames RHA.

The post in the South and West office will be advertised. In the meantime Ms Penny Humphries, development director, Wessex RHA, will act as director.

Mr Ken Jarrold, chief executive, Wessex RHA, is the NHS's new human resources director. He was appointed after open competition with candidates from industry and commerce. He will work on the development pay strategy with the Treasury and the NHS with particular responsibility for determining local pay and conditions.

Mr Alisdair Liddell, currently regional general manager of East Anglian RHA, has been seconded from the NHS to be director of planning and performance management. He will have a lead role in developing and strengthening strategic planning in the NHS.

Juniors' hours survey must be utilised Junior doctors are determined that the results in the survey on hours of work must be used to ensure that the targets set out in the new deal are …
Improvement of Paraneoplastic Opsoclonus-Myoclonus after Protein A Column Therapy
Authors: Mathias Nitschke, Fred Hochberg, Edward Dropcho
Journal: New England Journal of Medicine (1995)

To the Editor: Some patients with cancer have a paraneoplastic syndrome of opsoclonus-myoclonus (``dancing eyes-dancing feet''), which may be caused by antibodies directed against antigens shared b...
Herpes zoster of the anogenital area affecting urination and defaecation
Authors: PETER D. FUGELSO, WILLIAM B. REED, SIDNEY B. NEWMAN, JUNE E. BEAMER
Journal: British Journal of Dermatology (1973)

Journal Article Herpes zoster of the anogenital area affecting urination and defaecation Get access PETER D. FUGELSO, PETER D. FUGELSO St Joseph's Hospital, Burbank Search for other works by this author on: Oxford Academic Google Scholar WILLIAM B. REED, WILLIAM B. REED St Joseph's Hospital, Burbank Search for other works by this author on: Oxford Academic Google Scholar SIDNEY B. NEWMAN, SIDNEY B. NEWMAN Department of Dermatology, Long Beach VA Hospital, California, U.S.A Search for other works by this author on: Oxford Academic Google Scholar JUNE E. BEAMER JUNE E. BEAMER Department of Dermatology, Long Beach VA Hospital, California, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 89, Issue 3, 1 September 1973, Pages 285–288, https://doi.org/10.1111/j.1365-2133.1973.tb02975.x Published: 01 September 1973 Article history Accepted: 23 February 1973 Published: 01 September 1973
Combinatorial Treatments That Overcome PDGFRβ-Driven Resistance of Melanoma Cells to V600EB-RAF Inhibition
Authors: Hubing Shi, Xiangju Kong, Antoni Ribas, Roger S. Lo
Journal: Cancer Research (2011)

(V600E)B-RAF mutation is found in 50% to 60% of melanomas, and the novel agents PLX4032/vemurafenib and GSK2118436 that inhibit the (V600E)B-RAF kinase achieve a remarkable clinical response rate. However, as might be expected, acquired clinical resistance to these agents arises in most melanoma patients. PLX4032/vemurafenib resistance that arises in vivo in tumor matched short-term cultures or in vitro in melanoma cell lines is not caused by acquisition of secondary mutations in (V600E)B-RAF but rather is caused by upregulating platelet-derived growth factor receptor β (PDGFRβ) or N-RAS which results in resistance or sensitivity to mitogen-activated protein (MAP)/extracellular signal-regulated (ERK; MEK) kinase inhibitors, respectively. In this study, we define a targeted combinatorial strategy to overcome PLX4032/vemurafenib resistance in melanoma cell lines or short-term culture where the resistance is driven by PDGFRβ upregulation, achieving synergistic growth inhibition and cytotoxicity. PDGFRβ-upregulated, PLX4032-resistant (PPRM) cell lines show dual phospho (p)-ERK and p-AKT upregulation, and their growth inhibitory responses to specific small molecule inhibitors correlated with p-ERK, p-AKT, and p-p70S6K levels. Coordinate inhibition of (V600E)B-RAF inhibition and the RTK-PI3K-AKT-mTORC axis led to functionally significant rebound signaling, illustrating a robust and dynamic network connectivity. Combined B-RAF, phosphoinositide 3-kinase (PI3K), and mTORC1/2 inhibition suppressed both immediate early and delayed compensatory signaling, resulting in a highly synergistic growth inhibitory response but less efficient cytotoxic response. In contrast, the combination of MEK1/2, PI3K, and mTORC1/2 inhibitors consistently triggered apoptosis in a highly efficient manner. Together, our findings offer a rational strategy to guide clinical testing in preidentified subsets of patients who relapse during treatment with (V600E)B-RAF inhibitors.
Discordant Findings Between Krypton-81 m Gas and Tc-99m Labeled Ultrafine Aerosol Lung Ventilation SPECT in Two Patients With Idiopathic Pulmonary Fibrosis
Authors: NAOYUKI WATANABE, TOMIO INOUE, SHINICHI TOMIOKA, TATSUO YAMAJI, KEIGO ENDO
Journal: Clinical Nuclear Medicine (1995)

Technegas, a newly developed ultra-fine dry dispersion of Tc-99m labeled carbon with a particle size of approximately 5 nm to 20 nm, possesses the properties for lung ventilation imaging using SPECT. The authors observed a discrepancy between krypton-81m gas and technegas lung ventilation SPECT in two patients with idiopathic pulmonary fibrosis who demonstrated heterogeneously decreased distribution of technegas without regions of high count density (focal hot spots) of tracer in their lungs in spite of the almost homogenous distribution of krypton-81m gas. This finding could be explained by the duration of radioactive gas inhalation. Technegas lung ventilation SPECT images reflected lung ventilation with tidal breathing. Conversely, Kr-81m gas lung ventilation SPECT images reflected not only lung ventilation, but also lung volumes. These two radioactive agents for lung ventilation SPECT show different findings.
Detection of Unsuspected Malignant Pleural Effusion by Bone Scan
Authors: HAROLD A. GOLDSTEIN, WARREN B. GEFTER
Journal: Clinical Nuclear Medicine (1984)

Technetium-99m phosphate compounds may occasionally accumulate in malignant pleural effusions. A case of metastatic pleural effusion first diagnosed by bone scan, prior to its clinical or roentgenographic detection, is reported.
Are pre-hospital deaths from accidental injury preventable?
Authors: L M Hussain, A D Redmond
Journal: BMJ (1994)

To determine what proportion of pre-hospital deaths from accidental injury--deaths at the scene of the accident and those that occur before the person has reached hospital--are preventable.Retrospective study of all deaths from accidental injury that occurred between 1 January 1987 and 31 December 1990 and were reported to the coroner.North Staffordshire.Injury severity score, probability of survival (probit analysis), and airway obstruction.There were 152 pre-hospital deaths from accidental injury (110 males and 42 females). In the same period there were 257 deaths in hospital from accidental injury (136 males and 121 females). The average age at death was 41.9 years for those who died before reaching hospital, and their average injury severity score was 29.3. In contrast, those who died in hospital were older and equally likely to be males or females. Important neurological injury occurred in 113 pre-hospital deaths, and evidence of airway obstruction in 59. Eighty six pre-hospital deaths were due to road traffic accidents, and 37 of these were occupants in cars. On the basis of the injury severity score and age, death was found to have been inevitable or highly likely in 92 cases. In the remaining 60 cases death had not been inevitable and airway obstruction was present in up to 51 patients with injuries that they might have survived.Death was potentially preventable in at least 39% of those who died from accidental injury before they reached hospital. Training in first aid should be available more widely, and particularly to motorists as many pre-hospital deaths that could be prevented are due to road accidents.
Transition From Residency to Practice
Authors: Karen E. Deveney
Journal: JAMA Surgery (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
The Acute Hemodynamic Effects of MitraClip Therapy
Authors: Robert J. Siegel, Simon Biner, Asim M. Rafique, Michael Rinaldi, Scott Lim, Peter Fail, James Hermiller, Richard Smalling, Patrick L. Whitlow, Howard C. Herrmann, Elyse Foster, Ted Feldman, Donald Glower, Saibal Kar
Journal: Journal of the American College of Cardiology (2011)
Efficacité de la radiofréquence (RF) dans le traitement du reflux gastro-oesophagien (RGO): résultats d'une étude prospective randomisée multicentrique
Authors: E Coron, G Cadiot, F Zerbib, P Ducrotté, V Sébille, F Ducrot, P Pouderoux, J Arts, M Le Rhun, S Sacher Huvelin, S Bruley des Varannes, JP Galmiche
Journal: Endoscopy (2008)

Introduction: Le RGO est une affection fréquente qui peut retentir lourdement sur la qualité de vie des patients. Chez les malades dépendant d'un traitement par inhibiteurs de pompe à proton (IPP), le recours à la chirurgie représente une alternative possible, mais qui comporte une morbidité non négligeable. La radiofréquence (RF) selon la méthode STRETTA est une modalité endoscopique consistant à administrer un courant de haute fréquence dans la région cardiale. Le but de cette étude prospective randomisée ouverte était de comparer l'efficacité de la RF à la prise d'IPP seule chez des patients atteints de RGO.
Book: The Evolution of Hypnotism
Authors: D. Healy
Journal: BMJ (2000)

Derek Forrest, Anthony Storr Black Ace Books, £29.95, pp 383 ISBN 1872988377 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> The story of hypnotism is a multilayered one, covering the birth of psychotherapy as well as considering the complex interactions between nature and nurture. It is also a political story. Many of the original mesmerists were signatories to the first declarations proclaiming the French revolution in 1789. Far from being surprising, this was almost to be expected in that mesmerism opened up the prospect … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Short-Term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes
Authors: Edmond A. Ryan, Sharleen Imes, Clarissa Wallace
Journal: Diabetes Care (2004)

We thank Yoshioka, Yoshida, and Yoshikawa (1) for their interest and comments on our article (2) on the use of a short course of intensive insulin therapy in newly diagnosed type 2 diabetic patients. We are pleased that they think this strategy has merit. Our study was an initial pilot study and did not include detailed measures of insulin sensitivity, and we acknowledge this in the article.

Yoshioka, Yoshida, and Yoshikawa make the point that insulin secretion increased equally …
Impact of the etiology of congestive heart failure on chronotropic reserve after exercise training
Authors: Daniel Curnier, Michel Galinier, Atul Pathak, Joëlle Fourcade, Marc Bousquet, Jean‐Marie Fauvel, Jean‐Michel Senard, Jean‐Pierre Bounhoure, Jean‐Louis Montastruc
Journal: European Journal of Heart Failure (2000)
Euthanasia and Physician-Assisted Suicide among Patients with Amyotrophic Lateral Sclerosis in the Netherlands
Authors: Jan H. Veldink, John H.J. Wokke, Gerrit van der Wal, J.M.B. Vianney de Jong, Leonard H. van den Berg
Journal: New England Journal of Medicine (2002)

Amyotrophic lateral sclerosis (ALS) is a disease that causes progressive paralysis leading to respiratory failure. Patients with ALS may consider physician-assisted suicide. However, it is not known how many patients, if given the option, would actually decide to end their lives by physician-assisted suicide or euthanasia nor at what stage of the disease they would choose to do so.
Prevention of cerebral vasospasm by vasodilatory peptide maxadilan following subarachnoid hemorrhage in rabbits
Authors: Toshihiko Kaminuma, Hiroaki Shimizu, Ishtiaq Ahmad, Nobuhiko Ochiai, Ritsuko Ehama, Manami Ohnuma, Takaaki Banba, Kazuo Watabe, Ethan A Lerner, Shigeki Imaizumi, Masahiro Tajima, Takashi Yoshimoto
Journal: Journal of Controlled Release (1998)
Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.
Authors: P Carmeliet, J M Stassen, L Schoonjans, B Ream, J J van den Oord, M De Mol, R C Mulligan, D Collen
Journal: Journal of Clinical Investigation (1993)

The effects of plasminogen activator inhibitor-1 (PAI-1) gene inactivation on hemostasis, thrombosis and thrombolysis were studied in homozygous PAI-1-deficient (PAI-1-/-) mice, generated by homologous recombination in D3 embryonic stem cells. Diluted (10-fold) whole blood clots from PAI-1-/- and from PAI-1 wild type (PAI-1+/+) mice underwent limited but significantly different (P < 0.001) spontaneous lysis within 3 h (6 +/- 1 vs 3 +/- 1%, respectively). A 25-microliters 125I-fibrin-labeled normal murine plasma clot, injected into a jugular vein, was lysed for 47 +/- 5, 66 +/- 3, and 87 +/- 7% within 8 h in PAI-1+/+, heterozygous PAI-1-deficient (PAI-1+/-), and PAI-1-/- mice, respectively (P = 0.002 for PAI-1+/+ vs PAI-1-/- mice). Corresponding values after pretreatment with 0.5 mg/kg endotoxin in PAI-1+/+ and PAI-1-/- mice, were 35 +/- 5 and 91 +/- 3% within 4 h, respectively (P < 0.001). 11 out of 26 PAI-1+/+ but only 1 out of 25 PAI-1-/- mice developed venous thrombosis (P = 0.004) within 6 d after injection of 10 or 50 micrograms endotoxin in the footpad. Spontaneous bleeding or delayed rebleeding could not be documented in PAI-1-/- mice after partial amputation of the tail or of the caecum. Thus, disruption of the PAI-1 gene in mice appears to induce a mild hyperfibrinolytic state and a greater resistance to venous thrombosis but not to impair hemostasis.
Screening for thyroid dysfunction in diabetics.
Authors: J Feely, T E Isles
Journal: BMJ (1979)

<b>Background:</b> Rigid bronchoscopy yields a unique challenge for mechanical ventilation. An uncuffed and rigid bronchoscope requires mechanical ventilation strategies not often used. Manual jet ventilation is the most common approach and gold standard. At our hospital, we previously used either manual jet or an LTV-1200 ventilator during rigid bronchoscopy. We recently started using the Philips Respironics V60 ventilator because of its capabilities to ventilate with a leak. The rigid bronchoscopy cases subjectively had better and more stable ventilation. The purpose of this study was to perform a bench evaluation of various leak conditions comparing the V60 to the manual jet for ventilation during simulated rigid bronchoscopy. <b>Methods:</b> We performed a bench evaluation of rigid bronchoscopy with an intubation mannikin airway attached to the Ingmar ASL-5000 test lung with a Novametrix NM3-NICO flow sensor between the mannikin airway and the ASL-5000. Normal apneic adult settings were used on the ASL-5000. The manual jet was tested at 40 and 60 PSI with two breath types, "Burst" - shortest but full actuation of the jet valve and "Hold" - full actuation until inspiration ended. The V60 was tested with I-Times of 0.6 seconds and 1 second, with a delta pressure of 20cm H<sub>2</sub>O and 30 cm H<sub>2</sub>O. Two different leak scenarios were tested: "Low Leak" - typical setup of the rigid bronchoscope with the silicon cap in place. "High Leak" - setup without silicon cap in place. Inspiratory tidal volume was collected with each of the different scenario combinations with the NM3 device. <b>Results:</b> See graphic for the results of the inspiratory volume delivered with each device for the different scenarios. <b>Conclusions:</b> While the manual jet produced similar results regardless of leak it also produced the widest variation in tidal volumes: volumes that would be too low to maintain stable gas exchange ("burst" breaths) and large tidal volumes that could cause lung injury ("hold" breaths). This is dependent on the duration of the actuation of the manual jet with no user feedback for breaths that are too large. The V60 produced reasonable breaths during low leak (~300 to 500 mL) and dropped to ~100 mL during high leak. The results of this bench show that the V60 may be better from a lung injury standpoint and should support the patient through rigid bronchoscopy if high leak situations are kept short.
The Oliver-Sharpey Lectures ON HEART FAILURE: Delivered before the Royal College of Physicians of London
Authors: J. Mackenzie
Journal: BMJ (1911)

In seeking for a suitable subject, I considered the type of lecture usually given before you, and I found that most of your lectures deal with observations made in labora- tories, or drawn from hospital experiences, and rarely, if ever, deal with practical observations derived from general practice.
Income level and asthma prevalence and care patterns.
Authors: D Erzen, K C Carriere, N Dik, C Mustard, L L Roos, J Manfreda, N R Anthonisen
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Manitoba has a universally accessible health-care system that records physician contacts and hospitalizations in such a way that they can be ascribed to individuals. We examined the prevalence of physician-diagnosed asthma, bronchitis, and airways obstruction (total respiratory morbidity [TRM]) in Winnipeg in 1988 and 1992, using place of residence to divide people into quintiles according to average family income. Physician office visits, hospitalizations, and consultation referrals were each examined. Three age groups: 0 to 14 yr, 15 to 34 yr, and > or = 35 yr were studied. The prevalence of TRM was greater in low- than in high-income quintiles. Asthma prevalence was unrelated to income in the younger age groups; in the older group asthma was more common in low-income groups, but was less strongly related to income than was TRM. Asthma prevalence increased over the years studied, but the increase was not related to income level. There was some evidence of income-related diagnostic bias in that low-income patients were more likely to be labeled with a related diagnosis in addition to asthma than were high-income patients. Low-income patients had more physician contacts than did high-income patients. In terms of physician office visits, care continuity did not differ among income quintiles. Low-income quintiles had more hospitalizations than did high-income quintiles, and differences were larger than could be accounted for by diagnostic bias; asthma was probably more severe in low-income quintiles. High-income quintiles had more consultation referrals than did low-income quintiles.