tbuckley/cabot-search huggingface dataset:
PATIENTS WITH A SYSTEMIC RIGHT VENTRICLE: WHO ARE AT RISK OF CLINICAL EVENTS?
Authors: Teun van der Bom, Michiel Winter, Maarten Groenink, Hubert Vliegen, Petronella Pieper, Arie van Dijk, Gertjan Sieswerda, Jolien Roos-Hesselink, Aeilko Zwinderman, Barbara Mulder, Berto Bouma
Journal: Journal of the American College of Cardiology (2013)
Meta‐analysis of symptomatic response attributable to the pacing component of cardiac resynchronization therapy
Authors: S.M. Afzal Sohaib, Zhongbo Chen, Zachary I. Whinnett, Sonia Bouri, Kenneth Dickstein, Cecilia Linde, David L. Hayes, Charlotte H. Manisty, Darrel P. Francis
Journal: European Journal of Heart Failure (2013)
Cyclooxygenase-2 Regulates Th17 Cell Differentiation during Allergic Lung Inflammation
Authors: Hong Li, J. Alyce Bradbury, Ryan T. Dackor, Matthew L. Edin, Joan P. Graves, Laura M. DeGraff, Ping Ming Wang, Carl D. Bortner, Shuichiro Maruoka, Fred B. Lih, Donald N. Cook, Kenneth B. Tomer, Anton M. Jetten, Darryl C. Zeldin
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Th17 cells comprise a distinct lineage of proinflammatory T helper cells that are major contributors to allergic responses. It is unknown whether cyclooxygenase (COX)-derived eicosanoids regulate Th17 cells during allergic lung inflammation.To determine the role of COX metabolites in regulating Th17 cell differentiation and function during allergic lung inflammation.COX-1(-/-), COX-2(-/-), and wild-type mice were studied in an in vivo model of ovalbumin-induced allergic inflammation and an in vitro model of Th17 differentiation using flow cytometry, cytokine assays, confocal microscopy, real-time polymerase chain reaction, and immunoblotting. In addition, the role of specific eicosanoids and their receptors was examined using synthetic prostaglandins (PGs), selective inhibitors, and siRNA knockdown.Th17 cell differentiation in lung, lymph nodes, and bronchoalveolar lavage fluid was significantly lower in COX-2(-/-) mice after ovalbumin sensitization and exposure in vivo. In vitro studies revealed significantly impaired Th17 cell differentiation of COX-2(-/-) naive CD4(+) T cells with decreased Stat3 phosphorylation and RORγt expression. Synthetic PGF(2α) and PGI(2) enhanced Th17 cell differentiation of COX-2(-/-) CD4(+) T cells in vitro. The selective COX-2 inhibitor, NS-398, and PGF(2α) receptor and PGI(2) receptor siRNA knockdown significantly decreased Th17 cell differentiation in vitro. Administration of synthetic PGs restored accumulation of Th17 cells in lungs of allergic COX-2(-/-) mice in vivo.COX-2 is a critical regulator of Th17 cell differentiation during allergic lung inflammation via autocrine signaling of PGI(2) and PGF(2α) through their respective cell surface receptors.
Temporal Trends in Event Rates After Q-Wave Myocardial Infarction
Authors: Ursula C. Guidry, Jane C. Evans, Martin G. Larson, Peter W. F. Wilson, Joanne M. Murabito, Daniel Levy
Journal: Circulation (1999)

Background —Short-term (&lt;30 day) mortality after Q-wave myocardial infarction (MI) has declined over the decades, but it is unclear if rates of long-term sequelae after Q-wave MI have improved. Methods and Results —In 546 Framingham Heart Study subjects (388 men with a mean age of 60 years; 158 women with a mean age of 69 years) with an initial recognized Q-wave MI from 1950 through 1989, we investigated time trends in risk for coronary heart disease (CHD) death (n=199), all-cause mortality (n=287), reinfarction (n=108), and congestive heart failure (CHF; n=121). With 1950 through 1969 as the reference period, hazards ratios (HRs) for these outcomes were determined for the 1970s and 1980s. Trend analyses across the 3 time periods were performed for each outcome. Compared with the 1950 through 1969 reference period, the HRs for CHD death were lower in subsequent decades (1970 through 1979: HR, 0.69; 95% CI, 0.49 to 0.98; 1980 through 1989: HR, 0.48; 95% CI, 0.33 to 0.72). All-cause mortality also declined (1970 through 1979: HR, 0.70; 95% CI, 0.0.52 to 0.94; 1980 through 1989: HR, 0.59; 95% CI, 0.43 to 0.81). There were no significant temporal changes in the risks for recurrent MI or CHF. Conclusions —Substantial reductions in risk of CHD death and all-cause mortality occurred over these 4 decades, coincident with improvements in post-MI therapies. The absence of a decline in CHF incidence may be due to improved post-MI survival of individuals with depressed left ventricular systolic function who are at high risk for CHF.
Advances in Biomedical Engineering
Authors: Linda G. Griffith
Journal: JAMA (2001)

The most visible contributions of biomedical engineering to clinical practice involve instrumentation for diagnosis, therapy, and rehabilitation. Cell and tissue engineering also have emerged as clinical realities. In the next 25 years, advances in electronics, optics, materials, and miniaturization will accelerate development of more sophisticated devices for diagnosis and therapy, such as imaging and virtual surgery. The emerging new field of bioengineering-engineering based in the science of molecular cell biology-will greatly expand the scope of biomedical engineering to tackle challenges in molecular and genomic medicine.
Doctors as patients: postal survey examining consultants and general practitioners adherence to guidelines
Authors: M. Forsythe, M. Calnan, B. Wall
Journal: BMJ (1999)

<h3>Abstract</h3> <b>Objectives:</b> To examine the adherence by senior NHS medical staff to the BMA guidelines on the ethical responsibilities of doctors towards themselves and their families. <b>Design:</b> Postal semistructured questionnaire. <b>Setting:</b> Four randomly selected NHS trusts and three local medical committees in South Thames region. <b>Subjects:</b> Consultants and principals in general practice. <b>Main outcome measures:</b> Personal use of health services. <b>Results:</b> The response rate was 64% (724) for general practitioners and 72% (427) for consultants after three mailings. Most (1106, 96%) respondents were registered with a general practitioner, although little use was made of their services. 159 (26%) general practitioners were registered with a general practitioner in their own practice and 80 (11%) admitted to looking after members of their family. 73 (24%) consultants would never see their general practitioner before obtaining consultant advice. Most consultants and general practitioners admitted to prescribing for themselves and their family. Responses to vignettes for different health problems indicated a general reluctance to take time off, but there were differences between consultants and general practitioners and by sex. Views on improvements needed included the possibility of a "doctor9s doctor," access to out of area secondary care, an occupational health service for general practitioners, and regular health check ups. <b>Conclusion:</b> The guidelines are largely not being followed, perhaps because of the difficulties of obtaining access to general practitioners outside working hours The occupational health service should be expanded and a general practitioner service for NHS staff piloted. <h3>Key messages</h3> Senior doctors are not following the BMA guidelines on looking after their own and their families9 health They seem very reluctant to consult their general practitioner They prefer to self treat, carry on working, and consult informally Potential barriers to access should be removed in order to improve their health
Health symptoms during midlife in relation to menopausal transition: British prospective cohort study
Authors: G. D. Mishra, D. Kuh
Journal: BMJ (2012)

<b>Objective</b> To characterise symptoms experienced by women during the transition into natural menopause, to classify women into distinct symptom profiles or trajectories, and to relate these profiles to sociodemographic factors and health behaviours. <b>Design</b> Nationally representative cohort study. <b>Setting</b> England, Scotland, and Wales. <b>Participants</b> 695 women followed-up since birth in 1946 and annually from age 47 to 54 who experienced natural menopause and reported on 20 common health symptoms. <b>Main outcome measure</b> Longitudinal profiles for reported bothersome symptoms. <b>Results</b> Of 20 individual symptoms, 18 formed into four stable symptom groups: psychological, somatic, vasomotor, and sexual discomfort. Using latent class analyses, all except the somatic group of symptoms showed a clear relation with the timing of menopause for some women. A small proportion of women (10%, n=63) had a severe psychological symptom profile that peaked at or in the year after menopause. For vasomotor symptoms, 14% of women (n=83) had the early severe profile that also peaked around early postmenopause and then declined noticeably; 11% (n=67) had the late severe profile of bothersome symptoms that increased rapidly in perimenopause and remained high for four years or more after menopause. Women were less likely to have a profile for severe vasomotor symptoms if they were from a non-manual social class (odds ratio 0.79, 95% confidence interval 0.57 to 1.01) or had degree level qualifications (0.37, 0.18 to 0.77). The 14% of women (n=85) who had the late severe profile for sexual discomfort showed a similar increase in symptoms until menopause, with symptoms persisting after menopause. Married women were more likely to have the late severe or late moderate profile than women of other marital status (2.40, 1.30 to 4.41). Four profiles each were identified for somatic symptoms (mild, moderate, severe, and very severe), although these did not vary by chronological age or age at menopause. <b>Conclusion</b> Profiles for psychological, vasomotor, and sexual discomfort symptoms relative to age at menopause could help health professionals to tailor their advice for women with natural menopause.
European Commission bans Egyptian seeds over E coli fears
Authors: A. Tuffs
Journal: BMJ (2011)

The European Commission has banned the import of fenugreek seeds from Egypt after they were identified as the most likely source of the recent outbreak of Escherichia coli , which killed 48 people across Europe.

The ban was brought in after a report from the European Food Safety Authority last week that said that “one lot of fenugreek seeds imported from Egypt and used to produce sprouts is the most likely common link between the two outbreaks” (www.efsa.europa.eu/en/supporting/pub/176e.htm).

The authority recommends that the European Commission should …
Dengue and Hemorrhagic Fever
Authors: David M. Morens, Anthony S. Fauci
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Indications and Limitations in the Management Algorithm of Patients With Esophageal Adenocarcinoma
Authors: P. Marco Fisichella
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Effect of thoracic irradiation on hepatocyte growth factor in rats lung and in bronchoalveolar lavage fluid of patients with thoracic malignancies
Authors: H Yamazaki, E Takeuchi, JT Tang, S Fukushima, T Inoue, K Shinkawa, Y Watanabe, E Tanaka, T Teshima, S Ozeki, M Koizumi, M Ito, H Nakamura, T Inoue
Journal: European Respiratory Journal (1997)

This study aimed to examine the physiological role of hepatocyte growth factor (HGF) after thoracic irradiation. We analysed the changes of HGF protein levels in rat lung following 12 Gy of whole thoracic irradiation. Bronchoalveolar lavage fluid (BALF) was then collected from 11 patients (10 lung cancer and one oesophageal cancer) after completion of radiation therapy. One month after irradiation, the HGF protein level in the lungs of irradiated rats decreased (p&lt;0.05), followed by a remarkable elevation in HGF protein levels 2 (p&lt;0.05) and 3 months (nonsignificant) after irradiation accompanied by the clinical appearance of radiation pneumonitis. Finally, HGF protein levels in the lung returned to their original level 6 months after thoracic irradiation. In humans, HGF protein levels in the BALF in the limited irradiated area were lower than those obtained from unirradiated areas (p&lt;0.05). In conclusion, hepatocyte growth factor production is transiently suppressed in the irradiated area after irradiation.
Receptors in Breast Cancer
Authors: Marc E. Lippman, Joseph C. Allegra
Journal: New England Journal of Medicine (1978)

Estrogen Receptor and Endocrine Therapy of Breast CancerSINCE the pioneering work of George Beatson,1 who induced tumor regressions in patients with advanced breast cancer by oophorectomy, it has been appreciated that some human breast cancers will respond to endocrine manipulations. It is established that patients who respond to such endocrine therapies have not only palliation of their disease but increased survival as well. Unfortunately, no more than about a third of unselected patients with metastatic breast cancer will have objective tumor regressions after initiation of endocrine therapy. Thus, if endocrine therapies are applied nonselectively, the majority of patients will . . .
2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells
Authors: Andrew J. Steele, Archibald G. Prentice, A. Victor Hoffbrand, Birunthini C. Yogashangary, Stephen M. Hart, Mark W. Lowdell, Edward R. Samuel, Janet M. North, Elisabeth P. Nacheva, Anastasios Chanalaris, Panagiotis Kottaridis, Kate Cwynarski, R. Gitendra Wickremasinghe
Journal: Blood (2009)
Abnormal lymphocyte function is secondary to drug-induced autoimmunity.
Authors: S Pugh, B Pelton, E B Raftery, A M Denman
Journal: Annals of the Rheumatic Diseases (1976)

Abnormal lymphocyte function has been frequently reported in patients with connective tissue diseases but its significance has been uncertain. Sequential studies of lymphocyte function were carried out in patients receiving the beta-adrenergic blocking drug practolol (Eraldin) both before and during the development of autoimmune complications. No evidence was obtained that abnormal lymphocyte function presaged the onset of autoimmunity, and when these tests did show deficient responses these could be correlated with disease activity in general.
Generalized Pneumocystis carinii Infection with Severe Idiopathic Hypoproteinemia
Authors: STIG JARNUM
Journal: Annals of Internal Medicine (1968)

A case is reported of generalized Pneumocystis carinii infection. The patient, a 54-year-old man, developed pulmonary symptoms after he had felt extremely weak for more than 1 year. Because of radiological suspicion of a pulmonary cyst or abscess a lobectomy was performed. Microscopic examination showed Pneumocystis carinii pneumonia. Five months later the patient died from generalized Pneumocystis carinii infection. At autopsy numerous small abscesses were found in which the pneumocyst could be demonstrated. Hypoproteinemic edema developed 2 months before death. An extreme hypoalbuminemia was demonstrated (serum albumin, 0.2 g/100 ml), and there was a strongly reduced serum concentration of immunoglobulin (Ig)G but normal concentrations of IgA and IgM. Using 125I-albumin, a greatly increased turnover of albumin was demonstrated, as in proteinlosing states. However, there was no abnormal loss of plasma protein, in particular none in the gastrointestinal tract (normal 59Fe-iron-dextran test).
Ectopic Production of MDA-7/IL-24 Inhibits Invasion and Migration of Human Lung Cancer Cells
Authors: Rajagopal Ramesh, Isao Ito, Began Gopalan, Yuji Saito, Abner M Mhashilkar, Sunil Chada
Journal: Molecular Therapy (2004)

We have previously observed the suppression of lung tumor growth in response to overexpression of melanoma differentiation-associated gene-7 (MDA-7)/interleukin-24 (IL-24; approved gene symbol IL24) in vitro and in vivo. MDA-7/IL-24 exerts its tumor-suppressive effects by multiple mechanisms, including the activation of the caspase cascade and the inhibition of angiogenesis. In this study, we used an adenoviral vector (Ad-mda7) to examine the effect of the ectopic production of MDA-7/IL-24 on cell migration and invasion by human non-small-cell lung carcinoma cells. Lung tumor cells (H1299 and A549) treated in vitro with Ad-mda7 migrated and invaded less than cells treated with phosphate-buffered saline (PBS) or Ad-Luc (vector control). MDA-7/IL-24 inhibited migration and invasion by down-regulating the production of phosphatidylinositol 3-kinase/protein kinase B, focal adhesion kinase, and matrix metalloproteinase-2 and -9 relative to PBS and Ad-Luc. Furthermore, tumor cells treated with Ad-mda7 ex vivo or with DOTAP:Chol–mda7 complex in vivo formed significantly fewer tumors in an experimental lung metastasis model. These results show that MDA-7/IL-24 inhibits invasion and migration by lung cancer cells by down-regulating proteins associated with these processes, resulting in reduced metastasis. Thus, Ad-mda7 should be considered a therapeutic agent that can inhibit primary tumor growth and prevent metastasis.
Effects of N-acetylcysteine administration in hepatic microcirculation of rats with biliary cirrhosis
Authors: Ying-Ying Yang, Kuei-Chuan Lee, Yi-Tsau Huang, Ying-Wen Wang, Ming-Chih Hou, Fa-Yauh Lee, Han-Chieh Lin, Shou-Dong Lee
Journal: Journal of Hepatology (2008)
CARCINOSIS OF BRAIN AND SPINAL CORD.
Authors: WALTER TIMME
Journal: JAMA (1907)

This case is of rather more than usual interest inas-much as no diagnosis of the true lesion in the brain had been made before death. Five or six eminent neurologists at various times saw and carefully examined the patient in the course of the last two years, and their diagnoses varied from a "pure hysteria" to "neuritis based on morphinism." Only in a single instance did the opinion come near the truth. This was at a consultation about two years ago, at which it was maintained that the patient suffered from a metastatic tumor of the cord. It is only just to state that this latter diagnosis was, I believe, arrived at by exclusion and not directly from any symptoms. Nothing was stated of any possible brain involvement at any time. When it is seen how greatly the cerebral cortex had been interfered with, one can but wonder at the
Management of Brachial Plexus Palsies
Authors: Robert Iacono
Journal: JAMA (1982)

To the Editor.—  The article Functional Recovery and Orthopedic Management of Brachial Plexus Palsies (1981;246:2467) by M. Mark Hoffer, MD, subcategorizes 15 of 37 patients with no motor or sensory return. All experienced pain, nine in which pain was chronic and refractory to attempted therapies, including amputation and shoulder fusion. Undoubtedly these patients suffered brachial plexus avulsion and resultant deafferentation pain syndrome. Although conventional medical and surgical therapies are of little value, the contemporary technique of (spinal) dorsal root entry zone lesions relieves this central pain syndrome in more than two thirds of cases. 1 It is unfortunate to discuss rehabilitation but overlook an effective treatment for this neurosurgical disorder occurring in 40% of the avulsion group.
Scientific Evidence in the Courtroom -- The Death of the Frye Rule
Authors: George J. Annas
Journal: New England Journal of Medicine (1994)

In one of the most anticlimactic cases in recent years, the Supreme Court ruled on the last day of its 1992-1993 term that federal judges should admit all relevant scientific testimony and evidence that is “reliable”1. The result was so uncontroversial that both sides in the case said they were satisfied; because the result was also so vague, it will probably be years before its effect can be accurately ascertained. The facts of the case, Daubert v. Merrell Dow Pharmaceuticals, Inc.,1 are somewhat more interesting than its prosaic legal conclusion.Bendectin, an antinausea drug prescribed to a total of . . .
First and second degree atrioventricular block in oxpentifylline overdose.
Authors: I Sznajder, Y Bentur, U Taitelman
Journal: BMJ (1984)

Une tentative de suicide chez une femme de 22 ans. (4 a 6 g d'oxpentifylline). Bradycardie extreme, hypolkaliemie, bloc AV. Efficacite du traitement: lavages gastriques, charbon active, potassium, sous monitoring