Sjögren's Syndrome, Lymphoproliferation, and Renal Tubular Acidosis
Authors: NORMAN TALAL
Journal: Annals of Internal Medicine (1971)

Editorial Notes1 April 1971Sjögren's Syndrome, Lymphoproliferation, and Renal Tubular AcidosisNORMAN TALAL, M.D.NORMAN TALAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-4-633 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn Sjögren's syndrome, a connective tissue disease related to rheumatoid arthritis and systemic lupus erythematosus, the infiltration of salivary and lacrimal glands by lymphocytes and plasma cells eventually results in severe oral and ocular dryness. The earliest infiltrates are found around the small intralobular ducts. Ductal cells become hyperplastic, giving rise to the characteristic "epimyoepithelial islets." Hypergammaglobulinemia is often present, as well as antisalivary duct antibodies, rheumatoid factor, and antinuclear and other presumed autoantibodies.Lymphoid infiltrates sometimes involve other organs such as lung, liver, skeletal muscle, and kidney. These infiltrates may appear benign or malignant, depending on their extent, invasive...References1. MORRISFUDENBERG RH: Impaired renal acidification in patients with hypergammaglobulinemia. Medicine (Balt) 46:57-69, 1967 CrossrefMedlineGoogle Scholar2. SHEARNTU MW: Latent renal tubular acidosis in Sjogren's syndrome. Ann Rheum Dis 27:27-32, 1968 CrossrefMedlineGoogle Scholar3. TALALZISMANSCHUR NEP: Renal tubular acidosis, glomerulonephritis and immunologic factors in Sjogren's syndrome. Arthritis Rheum 11:774-786, 1968 CrossrefMedlineGoogle Scholar4. SHIOJIFURUYAMAONODERA RTS: Sjogren's syndrome and renal tubular acidosis. Amer J Med 48:456-463, 1970 CrossrefMedlineGoogle Scholar5. SAITOFURUYAMASHIOJI HTR: Polyacrylamide gel electrophoretic and immunochemical studies on urinary proteins in Sjogren's syndrome, with special reference to tubular proteinuria. Tohoku J Exp Med 101:205-214, 1970 CrossrefMedlineGoogle Scholar6. PASTERNACKLINDER AE: Renal tubular acidosis: an immunopathological study on four patients. Clin Exp Immun 7:115-123, 1970 MedlineGoogle Scholar7. MASONGOLDING AP: Hyperglobulinemic renal tubular acidosis: a report of nine cases. Brit Med J 3:143-146, 1970 CrossrefMedlineGoogle Scholar8. TALALASOFSKYLIGHTBODY NRP: Immunoglobulin synthesis by salivary gland lymphoid cells in Sjogren's syndrome. J Clin Invest 49:49-54, 1970 CrossrefMedlineGoogle Scholar9. SHEARNTUSTEPHENS MWB: Virus-like structures in Sjogren's syndrome. Lancet 1:568, 1970 CrossrefMedlineGoogle Scholar10. GRIMLEYTALAL PN: Unpublished observations Google Scholar11. TALAL N: Imunologic and viral factors in the pathogenesis of systemic lupus erythematosus. Arthritis Rheum. In press Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Arthritis & Rheumatism Branch National Institute of Arthritis and Metabolic Diseases National Institutes of Health Bethesda, Md. 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PRESCRIPTIONSalivary gland immunoglobulin and rheumatoid factor synthesis in Sjögren's syndromeRenal acidosisGeneralized auto-immune diseasesRenal Tubular Acidosis in LeprosyDAVID J. DRUTZ, M.D., ROBERT A. GUTMAN, M.D. 1 April 1971Volume 74, Issue 4Page: 633-634KeywordsConnective tissue diseasesHypergammaglobulinemiaKidneysLiverLungsLupus erythematosusLymphocytesPlasma cellsRheumatoid arthritisSkeletal muscles Issue Published: 1 April 1971 PDF downloadLoading ...