tbuckley/cabot-search huggingface dataset:
Alzheimer's disease and the beta amyloid gene.
Authors: P J Harrison
Journal: BMJ (1991)

infection: confidential counselling showed that 24 prisoners were HIV positive compared with an original estimate of two.'6The official figure for the number of HIV positive inmates in English prisons is 58.17At any time, however, there is a total of 45 000 prisoners; if 10% were estimated to be drug users8 and 5-10% of these were estimated to be HIV positive'3 this would mean that there were 225 to 450 seropositive drug users in prison.This estimation does not include homosexual inmates.HIV and AIDS have highlighted the lack of adequate medical care in the prison system, and a radical overhaul of prison medical services has been recommended.''" But even with good medical care, prisons were never meant to be 1 Adsisorv Couincil on the Misuse oft Drugs.AIDS and drug misuse, parl I. London:
Connective tissue origin of the amyloid-related protein SAA.
Authors: E Linder, R F Anders, J B Natvig
Journal: The Journal of Experimental Medicine (1976)

Protein SAA is a serum protein related to the major constituent of secondary amyloid fibrils, protein AA, and has been suggested to be a precursor of the amyloid protein AA. In the present study, the origin of SAA was investigated by studying human fetal tissues and cultured human fetal fibroblasts with the indirect immunofluorescence technique. Anti-SAA antibodies reacted strongly with cultured fibroblasts producing a fine fibrillary cytoplasmic staining and with extracellular fibrils in loose connective tissues and vessel walls. The reactions were specifically inhibited by absorption with degraded amyloid material, isolated protein AA, isolated protein SAA, and sera from patients with elevated levels of SAA. In contrast, no inhibition was seen with amyloid fibril material devoid of AA protein or by human sera in which SAA was not detectable by double-diffusion tests. These observations showed that SAA-like material is produced by fibroblasts and indicate that it is a normal constituent of developing extracellular connective tissue fibers.
To Dad, on Your Deathbed
Authors: Maureen Tolman Flannery
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Left axis deviation: a spectrum of intraventricular conduction block.
Authors: G Das
Journal: Circulation (1976)

The effects of left axis shift (greater than -30 degrees) on intraventricular conduction time (IVCT) were studied in 63 subjects in whom electrocardiograms before and after appearance of the left axis shift were available. Subjects with electrocardiographic evidence of left or right ventricular hypertrophy, left or right bundle branch block, myocardial infarction, pre-excitation and those receiving antiarrthymic drugs were excluded. The IVCT increased by an average of 25 msec when the QRS axis shifted to -30 degrees or beyond. When the individual AQRS was related to the IVCT a linear correlation (r = -0.8) was observed. It appears that a continuum relation between the AQRS and the IVCT exists throughout the counterclockwise range of +90 degrees to -90 degees. In all leftward shifts in AQRS from from +90 degrees there is a prolongation in IVCT. Our observations indicate that all leftward shifts in AQRS, including the extreme left axis shift (left anterior hemiblock), represent a spectrum of intraventricular conduction block.
Impact of haplotypes of TNF in the natural course of infective endocarditis
Authors: E. Giannitsioti, G. Damoraki, C. Rokkas, T. Tsaganos, A. Fragou, S. Kannelaki, S. Athanasia, E.J. Giamarellos-Bourboulis
Journal: Clinical Microbiology and Infection (2013)
UV Radiation and Skin Cancer: The Science behind Age Restrictions for Tanning Beds
Authors: Charles W. Schmidt
Journal: Environmental Health Perspectives (2012)

Every year, millions of people climb in various states of undress into warm, glowing tanning beds, where during a typical 2-to 15-minute session they'll absorb a controlled dose of ultraviolet (UV) radiation at an intensity up to two to three times stronger than the sunlight striking the equator at noon.The tanning industry has grown rapidly since the 1980s, 1 rising to an estimated 28 million users in the United States. 2 This rise has been accompanied by an increase in diagnoses of skin cancer.The reasons behind the rising skin cancer diagnoses remain open to debate.Some experts attribute the rise to more frequent skin cancer screening, whereas others blame environmental and behavioral risk factors, particularly changes in UV exposure.In this latter context, UV-emitting Focus
Role psychologique de l’acte medical en cardiologie
Authors: J.L. Jullien
Journal: Psychotherapy and Psychosomatics (1972)

The heart is the ideal target for psychosomatic pathology, since if this 'motor' stops, death follows. In coronary disease, the evil reputation of which has been made public by the news media, the patient wants the cardiologist to take over his fear of death, whereas the cardiologist is faced with his own death in the form of sudden death in general. His narcissism towards his therapeutic powers and his domination of the patient, upon whom he imposes a new way of life, is accompanied by a certain sadism which serves to conceal his vulnerability. In cardiac surgery, more spectacularly, the patient's narcissistic wishes are fulfilled, as well as his masochism, for he will have to undergo difficult times (in reanimation); he will take advantage of this to tyrannize those around him. The cardiologist will find his anxiety concentrated on the choice of the correct moment for the operation, at which he will be confronted, not by sudden death but by the risk of death he himself determines – a veritable 'Russian roulette' with all the macabre attraction of suicide.
Patients' Views of Direct Access to Specialists
Authors: Hava Tabenkin, Revital Gross, Shuli Brammli, Pesach Shvartzman
Journal: JAMA (1998)

Surveys carried out among users of medical services can be a useful tool for health care organizations in designing proper services. Specifically, patients' views of direct access to specialists can be useful to health organizations considering the gatekeeper model.To assess patients' opinions about direct access to specialists and referral to specialists through their primary care physician.An intercept survey, in which patients were interviewed at the randomly selected service provision sites, was carried out in 3 districts in Israel during 1995. A total of 1445 and 1289 patients were interviewed in primary care and specialty clinics, respectively.Primary care and specialty clinics in 3 regions in Israel serving 750000 members of Kupat Holim Clalit, Israel's largest sick fund.Hebrew-speaking members of Kupat Holim Clalit who visited the primary care or specialty clinics in the 3 regions during the study period.Rate of preferences for direct access to specialists and preferences for referral through primary care physician.Fifty-two percent of the respondents preferred direct access to specialists, while 48% preferred a referral from their primary care physician. Multivariate logistic regression analysis indicated that the preference for direct access was significantly lower among patients older than 45 years (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.62-0.91); patients whose primary care physician was a specialist in family medicine (OR, 0.80; 95% CI, 0.67-0.97); and patients who were satisfied with their primary care physician (OR, 0.34; 95% CI, 0.27-0.44). Preference for direct access was significantly higher among more highly educated patients (OR, 1.38; 95% CI, 1.16-1.65) and patients residing in Jerusalem (OR, 2.46; 95% CI, 2.05-2.95) and those younger than 45 years who were dissatisfied with their family physician or a primary care physician who was not board certified. If direct access was not available, 33% of respondents would leave the sick fund and 48% would remain; 19% did not know.Informing sick fund members, particularly the younger and more educated among them, about the advantages of consulting with the primary care physician, as well as providing specialty training in family medicine to primary care physicians, may reduce patients' preference for direct access to specialists.
Film or Digital Mammographic Screening?
Authors: D. David Dershaw
Journal: New England Journal of Medicine (2005)

The report by Pisano et al.1 of the results of the Digital Mammographic Imaging Screening Trial (DMIST) in this issue of the Journal adds important information that physicians will use to assess the value of a new technique in mammographic screening: digital-image acquisition and storage. Moreover, the report by Berry et al.,2 also in this issue of the Journal, adds evidence to the already abundant data that support the role of mammographic screening in reducing breast-cancer mortality. The latter report reminds us that the technical aspects of mammography influence the quality of breast-cancer screening.Some of the benefits of digital . . .
The Cambridge Cholera Fungus
Authors: C. S. Roy
Journal: BMJ (1887)

IN your issue of December 23 (p. 171) appears a letter from Dr. E. Klein, in which that gentleman attempts to show that the micro-organisms found by Dr. Graham Brown, Mr. Sherrington, and myself in the substance of the mucous membrane of the small intestine in cases of Cholera asiatica are nothing more than “common mould (probably aspergillus),” which has grown on and into the tissue during the process of hardening. We were and are, however, perfectly well acquainted with the fact that imperfectly preserved animal tissues are liable to be invaded by various forms of fungi, and took, therefore, precautions which we believe to be ample to prevent such contamination of our material. Moreover, the presence of the micro-organisms in certain parts of the tissues only, their absence in others or on the surface of the specimens, the fact that their presence in the part is accompanied by anatomical changes which could not have taken place during the process of hardening, and, most of all, the characters of the micro-organisms themselves, render such an hypothesis as that brought forward by Dr. Klein absolutely unacceptable.
FRACTURE OF THE MONTH — ONE YEAR
Authors: Edwin F. Cave
Journal: JAMA (1961)

As we review the "Fracture of the Month" presented by the Massachusetts General Hospital Fracture Clinic during the past year, we are impressed by the fact that these contributions represent a team effort, including members of the resident staff, as well as visiting orthopedic and plastic surgeons. The cases chosen have, on the whole, been difficult problems in management, and by reviewing the protocols the reader can observe that there has been far from unanimity of opinion as to the best methods to employ in treatment. This is as it should be. Such differences of opinion promote lively discussions by which we learn a great deal. Physicians who embark upon postgraduate teaching assume a responsibility which may be even greater than that undertaken by instructors of the undergraduate, because of the fact that much post-graduate instruction must be done by correspondence and, also, because some postgraduate students have more or
Surgical Management of Crohn's Colitis
Authors: George E. Block
Journal: New England Journal of Medicine (1980)

Surgical Management of Crohn's ColitisCROHN'S disease is not necessarily limited to the small bowel, as previously believed, but may also involve the colon.1 Colonic lesions may be present with ileal involvement, or the colon may be the only site. Disease of the colon and rectum presents special problems to the surgeon because of the propensity for recurrence, the frequent unavailability of distal gut for a satisfactory anastomosis, or the presence of perineal sepsis. At the University of Chicago Medical Center guidelines for the surgical treatment of Crohn's colitis have been based on our experience and that reported by others. . . .
&lt;emph type="ital"&gt;The Cannon Shot&lt;/emph&gt;
Authors: Thomas B. Cole
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peer Review and Federal Regulations
Authors: Robert Steinbrook
Journal: New England Journal of Medicine (2004)

Federal regulations that affect science and health are frequently controversial. Whether the topic is air pollution, stem-cell research, clean needles for injection-drug users, or pharmaceutical advertising, powerful economic and social interests are often at stake. It is hard to dispute the view that federal regulations — or the information disseminated by the federal government, more generally — should be based on data of the highest quality. It is far more difficult, however, for scientists and government officials to agree about how to achieve this goal and to keep political considerations from trumping science when policies are created. Former president Bill . . .
Altered polarity and expression of H+-ATPase without ultrastructural changes in kidneys of Dent's disease patients
Authors: Pierre Moulin, Takashi Igarashi, Patrick Van Der Smissen, Jean-Pierre Cosyns, Pierre Verroust, Rajesh V. Thakker, Steven J. Scheinman, Pierre J. Courtoy, Olivier Devuyst
Journal: Kidney International (2003)
Abstract 3260: Primary cilia are lost early in prostate cancer progression
Authors: Nadia Hassounah, Kimberly McDermott, Raymond Nagle
Journal: Cancer Research (2012)

Abstract Prostate cancer is the most prominently diagnosed cancer in men, aside from non-melanoma skin cancer, and the second leading cause of cancer related deaths in men in the U.S. Little is known about the role of primary cilia in prostate cancer progression, so our goal is to elucidate this role. Primary cilia are microtubule-based organelles present on many mammalian cell types and help the cell sense the extracellular environment. Various signaling pathways important in development involve primary cilia, such as the Hedgehog (Hh) and Wingless/Int (Wnt) pathways, and these pathways are known to be misregulated in prostate cancer. Dysfunction of primary cilia is the cause of numerous ciliopathies, such as polycystic kidney disease and Bardet-Biedl syndrome, and has been linked to cancers, like basal cell carcinoma and medulloblastoma. We hypothesize that primary cilia suppress prostate tumorigenesis, and cilia loss promotes prostate cancer by altering cell signaling pathways like Hh and canonical Wnt. To test this hypothesis, we looked in human prostate cancers at cilia, Hh and canonical Wnt signaling. Human prostate tissue from prostate cancer patients was stained for ciliary proteins (acetylated and gamma tubulin). The expressions of these proteins were analyzed using confocal microscopy and compared between adjacent normal, hyperplastic, prostatic intraepithelial neoplasia (PIN), malignant and perineural invasion areas of each patient's tissue. As a control, normal prostate tissue from bladder cancer patients who underwent prostatectomies as part of treatment was used. A marked decrease in the percentage of ciliated cells in cancer and PIN was observed compared to normal prostate tissue. Higher grade cancer (Gleason sum α7) also had fewer cilia than lower grade (Gleason sum = 6). We are currently investigating Hh and canonical Wnt signaling activity in serial sections of the tissue used to analyze primary cilia. The expressions of Beta-Catenin, a protein used to measure canonical Wnt signaling activity, and Gli1, a transcription factor used as a readout of Hh activity, are being analyzed based on expression levels and localization within the cell, and correlated to primary cilia data. Thus far, our results suggest a role of primary cilia in promoting prostate cancer progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3260. doi:1538-7445.AM2012-3260
Bryan Frederick Warren
Authors: S. Hughes, H. Rigby
Journal: BMJ (2013)

Bryan Frederick Warren came from humble beginnings in Cheshire to be one of the most influential gastrointestinal pathologists of his time. Educated at state schools in Nantwich, Bryan was the first boy in his village to go to grammar school and university. The villagers were rightly proud of him as he had grown up with a severe disability. At the age of 6 Bryan developed Crohn’s disease, which was to severely influence his life, shape his career, and eventually bring about his premature death. At times the young Bryan could barely walk to school because of his severe perianal disease. Swimming, riding bicycles, and many other normal schoolboy activities were impossible for him, but this may have been his inspiration to enter medicine. It was only through sheer determination and extra hard work that he achieved the grades needed despite a severe flare of his disease during his A levels. Bryan planned a career in medical gastroenterology, but he switched to pathology after trouble with the MRCP exam and never looked back.

During his training in Liverpool and Bristol, …
Human cardiosphere-seeded gelatin and collagen scaffolds as cardiogenic engineered bioconstructs
Authors: Isotta Chimenti, Giuseppe Rizzitelli, Roberto Gaetani, Francesco Angelini, Vittoria Ionta, Elvira Forte, Giacomo Frati, Olivier Schussler, Andrea Barbetta, Elisa Messina, Mariella Dentini, Alessandro Giacomello
Journal: Biomaterials (2011)
Clinical Screening as Compared with DNA Analysis in Families with Multiple Endocrine Neoplasia Type 2A
Authors: Cornelis Lips, Rudy M. Landsvater, Jo Hoppener, Rolf A. Geerdink, Geert Blijham, Joke M. Jansen-Schillhorn van Veen, Adriaan van Gils, Mireille J. de Wit, Richard A. Zewald, Marianne Berends, Frits A. Beemer, Joanneke Brouwers-Smalbraak, Rumo Jansen, Hans Kristian Ploos van Amstel, Theo van Vroonhoven, Thea M. Vroom
Journal: New England Journal of Medicine (1994)

Multiple endocrine neoplasia type 2A (MEN-2A) is characterized by medullary thyroid carcinoma in combination with pheochromocytoma and sometimes parathyroid adenoma. Missense mutations in the RET proto-oncogene are associated with MEN-2A. Their detection by DNA analysis allows the identification of carriers of the gene, in whom the risk of medullary thyroid carcinoma is 100 percent. We compared the reliability of biochemical tests with that of DNA analysis in identifying carriers of the MEN2A gene.
Distributed neural blackboards could be more attractive
Authors: André Grüning, Alessandro Treves
Journal: Behavioral and Brain Sciences (2006)

The target article demonstrates how neurocognitive modellers should not be intimidated by challenges such as Jackendoff's and should explore neurally plausible implementations of linguistic constructs. The next step is to take seriously insights offlered by neuroscience, including the robustness allowed by analogue computation with distributed representations and the power of attractor dynamics in turning analogue into nearly discrete operations.
Artists Always Sign Their Work
Authors: Maxon Buscher
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal