tbuckley/cabot-search huggingface dataset:
P68 Surgery for mesothelioma: the case for macroscopic complete resection
Authors: K. K. W. Lau, A. Nakas, D. A. Waller
Journal: Thorax (2010)

<h3>Objective</h3> The role for radical surgery for Malignant Pleural Mesothelioma (MPM) remains controversial. There are advocates of less radical ‘debulking surgery’ who argue against the need for removal of diaphragm and pericardium because of increased morbidity. We test the hypothesis that survival is increased by the more radical operations intended to remove all visible tumour and achieve macroscopic complete resection (MCR). <h3>Methods</h3> Over a 13-year period, 362 patients underwent therapeutic surgery for MPM: in-group MCR: 232 (64%) patients underwent either extra-pleural pneumonectomy (135 patients (37%)) or radical pleurectomy-decortication (97 patients (27%)) with resection of diaphragm and pericardium. Whilst in group D: 130 (36%) underwent debulking surgery leaving macroscopic tumour in situ (55 patients (15%) by thoracotomy and 75 patients (21%) by VATS). The patients in the MCR group were younger (mean age 57.9 vs 66.1, p&lt;0.0001) and more had epithelioid subtype (167 (72%) vs 86 (66.2%), p&lt;0.0001). We compared the hospital outcomes and overall survival between these two groups. <h3>Results</h3> The mean length of stay was longer in group MCR than in group D (16.0 days vs 9.6 days, p&lt;0.0001) but 30-day mortality was similar (12 (5.2%) vs 8 (6.2%), p=0.811). In univariate analysis, overall survival was significantly longer in the MCR group (mean survival 22 months vs 13 months, p&lt;0.0001). A similar benefit was observed for the epithelioid pathological subgroup (mean survival 25.8 months vs 16.6 months, p&lt;0.0001). Cox regression showed that surgery intended to achieve MCR was associated with a significantly reduced hazard of death after adjusting for age and pathological subtype (HR 0.72, 95% CI 0.55 to 0.93, p=0.014). <h3>Conclusions</h3> Surgery to increase survival in mesothelioma should be based on an intent to achieve macroscopic complete resection. This strategy should form the basis of future trials to evaluate the role of surgery in this disease.
Certains aspects spécifiques de la psychothérapie des névroses à l’hôpital de jour
Authors: Jerzy W. Aleksandrowicz
Journal: Psychotherapy and Psychosomatics (1978)

Case Reports| February 16 2010 Certains aspects spécifiques de la psychothérapie des névroses à l'hôpital de jour Subject Area: Psychiatry and Psychology Jerzy W. Aleksandrowicz Jerzy W. Aleksandrowicz Département de Psychothérapie à la Chaire de Psychiatrie de l'Académie de Médecine de Cracovie, Cracovie Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 93–96. https://doi.org/10.1159/000287106 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Jerzy W. Aleksandrowicz; Certains aspects spécifiques de la psychothérapie des névroses à l'hôpital de jour. Psychother Psychosom 31 December 1978; 29 (1-4): 93–96. https://doi.org/10.1159/000287106 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Special Report on Laetrile: The NCI Laetrile Review
Authors: Neil M. Ellison, David P. Byar, Guy R. Newell
Journal: New England Journal of Medicine (1978)

Abstract The National Cancer Institute, in response to widespread public interest, undertook a retrospective analysis of Laetrile treatment. Only cases thought to have shown objective benefit from Laetrile were solicited by mail request to 385,000 physicians and 70,000 other health professionals and by direct contact with pro-Laetrile groups. Although it is estimated that at least 70,000 Americans have used Laetrile, only 93 cases were submitted for evaluation. Twenty-six of these Laetrile cases had to be eliminated because of insufficient documentation, and an equal number of conventionally treated cases selected from the Institute's files were added to the records to be analyzed. A panel of 12 oncologists, who had no knowledge of the actual treatments given, was then asked to evaluate the results of 160 courses of treatment (68 Laetrile, 68 chemotherapy, 24 "no treatment") in the abstracted records from 93 patients. The panel judged six Laetrile courses to have produced a response (two complete and four partial). These results allow no definite conclusions supporting the anti-cancer activity of Laetrile. The National Cancer Institute will use the data in deciding if further study is needed.
Unified Effort in Scientific Lobbying Makes Progress
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Unified Effort in Scientific Lobbying Makes Progress Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 19, 3 October 1990, Pages 1529–1530, https://doi.org/10.1093/jnci/82.19.1529 Published: 03 October 1990
Joint pain in hereditary multiple exostoses
Authors: D. J. Bruce, D. Whitwell, H. Pandit
Journal: BMJ (2015)

A 72 year old man who had never undergone joint surgery was referred to an orthopaedic clinic because of pain and stiffness in his right hip, which had been gradually worsening for many years. He was known to have hereditary multiple exostoses but was otherwise well. He had not noticed any recent new bony lumps. Pelvic radiography was performed (fig 1⇓).



Fig 1 Anterioposterior pelvic radiograph of the patient





### 1. What abnormalities does the radiograph show?

#### Short answer

Bilateral osteoarthritis (right worse than left) and polyostotic multiple bone exostoses, with extensive surrounding mineralisation into the soft tissues.

#### Long answer 

The radiograph (fig 2⇓) shows bilateral osteoarthritis (right worse than left) and polyostotic multiple bone exostoses, with extensive surrounding mineralisation into the soft tissues.



Fig 2 Anterioposterior pelvic radiograph showing bilateral osteoarthritis (right worse than left) and polyostotic multiple bone exostoses (arrows), with extensive surrounding mineralisation into the soft tissues (asterisk)



Osteochondromas are the most common bone tumour, comprising up to half of benign bone growths. They are composed of cortical and medullary bone in continuity with that of the underlying bone, with a hyaline cartilage cap. The long bones of the lower limb are most commonly affected, although lesions can be seen in the upper limbs, scapular bone, pelvis, spine, and head.1 2 The nature of osteochondromas is unclear, and many clinicians treat them as if they were tumours. However, recent studies suggest that they consist of a non-clonal mixture of cells and are not true cancers.3 The lesions arise by separation of a fragment of the epiphyseal growth plate that herniates through the periosteal bone cuff surrounding the growth plate …
New NHS pay scheme shows no productivity gains but did not add extra costs
Authors: A. McGauran
Journal: BMJ (2009)

<h3>Background</h3> Young people with mental health challenges present a major global challenge. More than half of adults with mental disorders experience their onset before age 14, but early detection and intervention may change this course. Shared care with mental health professionals in general practitioner (GP) offices has demonstrated its potential for improvement in these conditions. <h3>Aim</h3> To investigate whether shared care with mental health professionals in GP offices increases the detection of youth’s mental health disorders and is associated with a decrease in use of unspecified symptom diagnoses, as a whole and stratified by patient and physician gender and age, and type of consulting physician. <h3>Design and setting</h3> This was a stratified cluster-randomised controlled trial with data extraction from electronic records. Two GP offices were recruited from each of three boroughs. Each borough had 3–8 GP offices. One GP office was randomised to the intervention group and the other to the control group. <h3>Method</h3> We used generalised linear mixed models to assess whether the intervention helped GPs identify more International Classification of Primary Care 2 diagnoses of depression, anxiety and unspecified symptoms in youth. <h3>Results</h3> Over a 18-month period between between 2015 and 2017, the intervention helped GPs identify more youth with anxiety (p=0.002 for interaction), but not depression. The increase was most significant among the patients’ regular GPs, less when patients met other GPs and least among external substitute physicians. The frequency of diagnoses with unspecified symptoms decreased in the intervention arm. <h3>Conclusion</h3> Shared care with mental health professionals located in GP office contributed to increased detection of youth with anxiety symptoms. The increase was most prominent when the primary care physician was the patient’s regular GP. GPs need to pay greater attention to detecting anxiety in youth and embrace shared care models, thereby contributing to reduced mental health disorders in this age group. <h3>Trial registration number</h3> NCT03624829; Results.
The pacing stress test reexamined: Correlation of pacing-induced hemodynamic changes with the amount of myocardium at risk
Authors: Raymond G. McKay, Julian M. Aroesty, Gary V. Heller, Kenneth J. Silverman, J. Anthony Parker, Ann V. Als, Patricia C. Come, Gerald M. Kolodny, William Grossman
Journal: Journal of the American College of Cardiology (1984)
Digoxin in Heart Failure
Authors: Thomas W. Smith
Journal: New England Journal of Medicine (1993)

Although two centuries of anecdotal clinical evidence support the use of cardiac glycosides for the treatment of heart failure, controversy has surrounded their efficacy and appropriate indications. Early in this century, two of the founders of the clinical discipline of cardiology, Sir James Mackenzie in London and Henry Christian in Boston, had sharply differing views that have tended to persist in the United Kingdom and the United States, respectively. Mackenzie advocated the use of digitalis only in patients with supraventricular tachyarrhythmias, such as atrial fibrillation, whereas Christian believed that “digitalis . . . has a striking effect on those changes . . .
WHO says SARS outbreak is over, but fight should go on
Authors: F. Fleck
Journal: BMJ (2003)

The World Health Organization said on 5 July that the global outbreak of severe acute respiratory syndrome (SARS) had been contained, but it urged health authorities across the world not to be complacent, because the world was not yet free of the disease.

WHO removed Taiwan, where the last SARS case was detected and the patient isolated on 15 June, from a list of areas of recent transmission that travellers are advised to avoid.

WHO officials said the patient in Taiwan had passed two consecutive incubation periods of 10 days without passing …
Cycle length alternation in circus movement tachycardia using an atrioventricular accessory pathway. A study of the role of the atrioventricular node using a computer model of tachycardia.
Authors: D L Ross, W R Dassen, E J Vanagt, P Brugada, F W Bär, H J Wellens
Journal: Circulation (1982)

The possible role of the atrioventricular nodal (AVN) function curve during tachycardia as a cause of cycle length alternation was investigated using a computer model of circus movement tachycardia utilizing an atrioventricular accessory pathway. Two types of AVN function curves during tachycardia were entered into the computer: straight lines of various gradients and representative examples of patient-based AVN function curves obtained during clinical electrophysiologic studies. Perturbations of the tachycardia model were induced by introducing a short cycle, by suddenly prolonging a conduction interval, or by moving the AVN function curve relative to that in stable tachycardia. Using the straight line AVN function curves, stable, sustained cycle length alternation could be induced by perturbation of the tachycardia cycle if the gradient of the line was -1 (slope = 45 degrees). If the gradient was more than -1 (slope less than 45 degrees), the perturbation was damped. If the gradient was less than -1 (slope greater than 45 degrees), the perturbation was amplified, leading to termination of tachycardia by block in the AVN. Similar but more complex responses to perturbation of tachycardia were found using patient-based AVN function curves. Thus, sustained cycle length alternation and amplification or damping of perturbation could be produced. Using physiologic AVN function curves, the response to perturbation of tachycardia depended on the interrelationship of the shape of the AVN function curve, the location of the cycle length of tachycardia on the curve, the magnitude and direction of the perturbation, and the AVN effective refractory period. We conclude that cycle length alternation during tachycardia may be explained by the characteristics of a single antegrade AVN function curve without postulating the presence of additional AVN pathways. The stability of circus movement tachycardias depends on the interaction of several variables.
FURTHER STUDIES OF THE INTRACELLULAR BACTERIAL TOXINS.
Authors: VICTOR C. VAUGHAN
Journal: JAMA (1904)

For the past eight years much of my time, so far as it could be given to research work, has been devoted to a study of the intracellular toxins of bacteria, and the purpose of this paper is to briefly state what I have accomplished along this line, and to formulate the theoretical conceptions that have grown out of this investigation. In this work I have been aided by several most competent assistants and students, all of whom have labored without any remuneration worthy of mention, except that which comes to everyone who engages in scientific research intelligently and conscientiously. In 1896 Perkins and I<sup>1</sup>reported the presence in a toxicogenic bacterium found in poisonous ice cream of an active body that proved to be soluble in alcohol, and in this respect, at least, as we shall see later, similar to the toxins which we have recently been studying.
Association Between Diabetes and Mental Disorders in Two American Indian Reservation Communities
Authors: Luohua Jiang, Janette Beals, Nancy R. Whitesell, Yvette Roubideaux, Spero M. Manson
Journal: Diabetes Care (2007)

A rapidly growing body of research exists on the association between diabetes and mental disorders (1–6). Yet, limited information is available regarding mental disorders among ethnic minorities with diabetes, particularly American Indians. We examined the association of mental disorders and diabetes in two American Indian populations using data from a large community-based psychiatric epidemiological study.

The American Indian Service Utilization, Psychiatric Epidemiology, Risk and Protective Factors Project (AI-SUPERPFP) was conducted in two American Indian reservation communities. The methods are described in greater detail in a previous report (7) and on the study's Web site (http://www.uchsc.edu/ai/ncaianmhr/research/superpfp.htm). Data were collected between 1997 and 1999 from enrolled members of Southwest and Northern Plains tribes. To allow direct comparisons to the National Comorbidity Survey (8), only those who were aged 15–54 years at the time of sampling were included. For confidentiality purposes, we use the general descriptors of Northern Plains and Southwest rather than specific tribal names. Among those located and determined eligible, 76.8% in the Northern Plains and 73.7% in the Southwest tribes agreed to participate ( n = 3,084; 1,638 Northern Plains and 1,446 Southwest).

Self-reported diabetes status was assessed by the question “Did a doctor, medicine man, or other health care professional ever tell you that you …
Research on Major Depression
Authors: Thomas R. Insel, Dennis S. Charney
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dutch research community is shocked by cases of scientific misconduct
Authors: T. Sheldon
Journal: BMJ (2011)

Disciplinary action against a third professor in as many weeks has sparked soul searching among the Dutch medical research community.

Rotterdam’s Erasmus Medical Center recently dismissed Don Poldermans, a prominent professor of perioperative cardiovascular care, for “serious violations of scientific integrity” in his research.

His dismissal came weeks after the publication of a report by the Universities of Tilburg, Amsterdam and Groningen which found Diederik Stapel, professor of cognitive social psychology, guilty of ”unprecedented” fraud.( BMJ 2011;343: d7201, doi:10.1136/bmj.d7201)

Now Radboud University Nijmegen has “reprimanded for unprofessional conduct” its professor of social psychology Roos Vonk. Though not guilty of fraud, the design of a study in which she collaborated with …
Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma
Authors: Jin‐Ping Lai, Dalbir S. Sandhu, Chunrong Yu, Tao Han, Catherine D. Moser, Kenard K. Jackson, Ruben Bonilla Guerrero, Ileana Aderca, Hajime Isomoto, Megan M. Garrity‐Park, Hongzhi Zou, Abdirashid M. Shire, David M. Nagorney, Schuyler O. Sanderson, Alex A. Adjei, Ju‐Seog Lee, Snorri S. Thorgeirsson, Lewis R. Roberts
Journal: Hepatology (2008)

It has been shown that the heparin-degrading endosulfatase, sulfatase 1 (SULF1), functions as a liver tumor suppressor, but the role of the related sulfatase, sulfatase 2 (SULF2), in liver carcinogenesis remains to be elucidated. We investigated the effect of SULF2 on liver tumorigenesis. Expression of SULF2 was increased in 79 (57%) of 139 hepatocellular carcinomas (HCCs) and 8 (73%) of 11 HCC cell lines. Forced expression of SULF2 increased HCC cell growth and migration, whereas knockdown of SULF2 using short hairpin RNA targeting SULF2 abrogated HCC cell proliferation and migration in vitro. Because SULF1 and SULF2 desulfate heparan sulfate proteoglycans (HSPGs) and the HSPG glypican 3 (GPC3) is up-regulated in HCC, we investigated the effects of SULF2 on GPC3 expression and the association of SULF2 with GPC3. SULF2-mediated cell growth was associated with increased binding of fibroblast growth factor 2 (FGF2), phosphorylation of extracellular signal-regulated kinase and AKT, and expression of GPC3. Knockdown of GPC3 attenuated FGF2 binding in SULF2-expressing HCC cells. The effects of SULF2 on up-regulation of GPC3 and tumor growth were confirmed in nude mouse xenografts. Moreover, HCC patients with increased SULF2 expression in resected HCC tissues had a worse prognosis and a higher rate of recurrence after surgery. Conclusion: In contrast to the tumor suppressor effect of SULF1, SULF2 has an oncogenic effect in HCC mediated in part through up-regulation of FGF signaling and GPC3 expression. (HEPATOLOGY 2008.)
Transatlantic Conference on Clinical Trial Guidelines in Peripheral Arterial Disease
Authors: Karl-Heinz Labs, John A. Dormandy, Kurt A. Jaeger, Claus-Steffen Stuerzebecher, William R. Hiatt
Journal: Circulation (1999)

Abstract —Guidelines for the clinical development of drugs in peripheral arterial disease (PAD) have been issued by the Food and Drug Administration for the United States and by the regulatory agency of the European Union for Europe. With increasing globalization, transatlantic cooperation in drug research and development is essential for the future and would be substantially facilitated by the existence of transatlantic guidelines. A conference was held in Basel, Switzerland, in November 1997 to discuss the scientific background of the existing guidelines on the basis of published evidence and the extensive knowledge of clinical investigators and experienced regulators. The meeting was attended by 52 invited experts from the United States and Europe, as well as by representatives from the 2 regulatory authorities. The main conclusions from the meeting are presented and may serve as a reference for the future development of transatlantic guidelines for the evaluation of pharmacotherapy in PAD.
WHITEHEAD'S OPERATION FOR HAEMORRHOIDS
Authors: E. S. Bishop
Journal: BMJ (1909)

AFrr'a twenty years' experience of various 'the cure of haemorrhoids, I have no hesitation recom--mending Whitehead's operation as at once -effective, the least painful, and the safest method, necessary for success that certain precautions taken beforehand, and that the technique should carefully carried out.The condition being one which is frequent, abundant opportunities have occurred during mentioned both for the trial of the many recommended in surgical works and journals, estimation of final results.In the early days of my surgical practice clamp and cautery method, later the method ligature, ,occasionally other plans, such as injection carbolic acid, ignipuncture, etc., but for many yeare all been abandoned in favour of the method introduced Mr. Whitehead, which has given me 'satisfactory results.