tbuckley/cabot-search huggingface dataset:
P3-07-10: Sentinel Lymph Node Navigation Surgery Using Combination of Indocyanine Green Fluorescence and Blue Dye for Breast Cancer Patients.
Authors: M Takahashi, T Hayashida, H Jinno, Y Kitagawa
Journal: Cancer Research (2011)

Abstract Background: Sentinel lymph node (SLN) biopsy is now widely accepted for staging the axilla in breast cancer patients. Several methods are presently used to detect SLNs. Combined use of blue dye and radiocolloid has previously been described as a superior method for detecting SLNs in breast cancer patients, but radiocolloid is not generally available in Japan. SLN detection guided by indocyanine green (ICG) fluorescence could emerge as a new and effective method for SLN biopsy. The aim of this study was to evaluate SLN biopsy using combination of ICG fluorescence and blue dye methods for breast cancer patients. Material and Methods: We enrolled 75 patients with clinically node-negative breast cancer. An isosulfan blue dye solution (5ml) was injected subcutaneously just above the tumor and in the periareolar area after the induction of anesthesia. The injection site was massaged for five minutes and ICG (2ml) was then injected subcutaneously just above the tumor and in the periareolar area before starting the surgical procedure. Subcutaneous lymphatic channels draining from the areola to the axilla were visualized with a fluorescence imaging system (Photodynamic Eye: PDE, Hamamatsu Photonics Corporation, Japan) under fluorescence within several minutes. SLNs were dissected under direct visualization supported by fluorescence and dye navigation and diagnosed by intraoperative frozen section with hematoxylin and eosin staining. Any patient with a positive SLN underwent immediate axillary lymph node dissection (ALND). Results: SLNs were detected in all 75 patients. The fluorescence imaging identified 2.6 SLNs in 74 (98.7%) of 75 patients. The blue dye identified 1.6 SLNs in 68 (90.1%) of 75 patients. Twelve of the 75 (16.0%) patients had metastatic SLNs and ALND was immediately performed. No metastasis revealed in any non-SLN in eight of these 12 patients. Metastatic SLNs were detected by the ICG fluorescence and not by blue dye in four of these 12 patients. Discussion: The combination of ICG fluorescence and blue dye method had two advantages: it could reveal lymph flow on the surface before we determined the skin incision line; and it had a high SLN detection rate. In hospitals where radioisotopes are unavailable, a combination of the two methods would be advantageous. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-07-10.
Histomorphological reaction of bone to different concentrations of phagocytosable particles of high-density polyethylene and Ti-6Al-4V alloy in vivo
Authors: S.B. Goodman, J.A. Davidson, Y. Song, N. Martial, V.L. Fornasier
Journal: Biomaterials (1996)

Wear debris has been implicated in the pathogenesis of loosening and osteolysis of total joint replacements by stimulating a foreign body and chronic inflammatory reaction capable of bone resorption. Whether increasing concentrations of wear particles have an adverse biological effect on bone has not been elucidated. We performed a histomorphological and semi-quantitative morphometric analysis of the reaction of bone to different concentrations of phagocytosable particles of high-density polyethylene (HDPE) and titanium 6-aluminium 4-vanadium alloy (Ti-6Al-4V) implanted in the rabbit tibia. The Ti-6Al-4V particles had a diameter of 4.0 ± 4.4 μm (mean ± SD); the HDPE particles averaged 4.7 ± 2.1 μm. Suspensions of 106–109 particles per ml were mixed in saline, sterilized, and introduced through a drill hole into the proximal tibia of 30 mature female rabbits. Controls included drilled, but non-implantable limbs. The animals were killed at 16 weeks and histological sections were made of the implant area. Histomorphological assessment was carried out using an interactive image analysis system. The parameters assessed included the presence of histiocytes, foreign body giant cells and inflammatory cells, the location and number of particles, the presence of haematopoeitic elements, fat or necrosis of the marrow, whether healing of the cortical window had taken place, and whether there was evidence of formation or resorption of bone by the periosteum, cortex and marrow. A semi-quantitative rating system was employed. Phagocytosable particles of Ti-6Al-4V and HDPE, in concentrations of 106–109 particles per ml, evoked a histiocytic reaction without extensive fibrosis, necrosis or granuloma formation. This reaction occurred without disturbing the normal repair processes of bone formation and resorption to the surgical insult. A clear dose-response effect on the histological parameters assessed in this study was not noted. Using the present model, by 16 weeks, a similar 'one time' particle load could be accommodated. The ongoing generation of particulate debris over a more extended period of time might be necessary before the remodelling processes of bone would be disturbed.
The Status of Blacks in Medicine
Authors: Louis W. Sullivan
Journal: New England Journal of Medicine (1983)

Of interest to those in medicine and the other health professions is a study recently completed by the Association of Minority Health Professions Schools.1 The members of this association are from eight predominantly black health-professions schools: Morehouse School of Medicine (Atlanta), Charles R. Drew Medical School (Los Angeles), Meharry Medical College, Meharry Dental School (Nashville), Tuskegee Institute School of Veterinary Medicine (Tuskegee, Ala.), the Colleges of Pharmacy at Texas Southern University (Houston), Xavier University (New Orleans), and Florida Agricultural and Mechanical University (Tallahassee).The study provides a current perspective on the poor health status of blacks in the United States. . . .
GP who ran an out of hours locum service has most GMC charges dismissed
Authors: C. Dyer
Journal: BMJ (2014)

A GP who was suspended for nearly four years and faced serious charges by the General Medical Council (GMC) has won a ruling that his fitness to practise is not impaired, after most of the allegations against him were thrown out or found to be not proved.

Ravi Sondhi, who ran a south London out of hours locum service called Croydoc, faced allegations that he dishonestly took unauthorised advances totalling £100 000 (€125 000, $170 000) from the service, failed to provide good clinical care, and dishonestly represented to fellow directors the level of doctor coverage provided.

Sondhi was suspended on an interim basis by the GMC in January 2010. The suspension was renewed periodically until September 2013 when a High Court judge refused to renew …
ACUTE HEPATIC COMA TREATED BY CROSS-CIRCULATION WITH A BABOON AND BY REPEATED EXCHANGE TRANSFUSIONS
Authors: S.J. Saunders, J. Terblanche, S.C.W. Bosman, G.G. Harrison, R. Walls, R. Hickman, J. Biebuyck, D. Dent, S. Pearce, C.N. Barnard
Journal: The Lancet (1968)
Fever of Undetermined Origin
Authors: George A. Jacoby, Morton N. Swartz
Journal: New England Journal of Medicine (1973)

ONE of the most challenging problems in medicine is that presented by the patient with prolonged undiagnosed fever. It is important to recognize that the majority of such obscure fevers ultimately prove to be due to atypical manifestations of commoner diseases rather than to exotic illnesses. Although fever of undetermined origin is not a new problem, it has assumed increasing importance in the past 10 to 15 years because of the availability of newer therapeutic approaches.DefinitionIn their classic monograph on "fever of unexplained origin," Petersdorf and Beeson1 established certain criteria that have effectively delineated this entity: an illness . . .
Elevated serum concentrations of cardiac troponin T in acute allograft rejection after human heart transplantation
Authors: Thomas J Dengler, Rainer Zimmermann, Klaus Braun, Margit Müller-Bardorff, Jörg Zehelein, Falk-Udo Sack, Philipp A Schnabel, Wolfgang Kübler, Hugo A Katus
Journal: Journal of the American College of Cardiology (1998)
OSTEOPROTOGERIN AND OSTEOPONTIN SERUM LEVELS ARE ASSOCIATED WITH ARTERIAL WALL PROPERTIES AND WITH THE SEVERITY OF CORONARY ARTERY DISEASE
Authors: Konstantinos Maniatis, Gerasimos Siasos, Dimitris Tousoulis, Evangelos Oikonomou, Marina Zaromitidou, Stamatios Kioufis, Antigoni Miliou, Charalambos Vlachopoulos, Manolis Vavuranakis, Constantina Aggeli, Aris Plastiras, Athanasios Papavassiliou, Christodoulos I Stefanadis
Journal: Journal of the American College of Cardiology (2013)
Effects of Combined Insulin-Sulfonylurea Therapy in type II Patients
Authors: Moira S Lewitt, Vincent KF Yu, George C Rennie, John N Carter, Geoffrey M Marel, Dennis KS Yue, Michael J Hooper
Journal: Diabetes Care (1989)

We conducted a double-blind crossover study to determine which patient characteristics best predict a beneficial response to combined insulin-glyburide therapy. Glyburide (15 mg/day) or placebo was added to the treatment regimen of 31 insulin-treated type II (non-insulin-dependent) diabetic subjects. During glyburide therapy, there was a significant improvement in glycemic control with a reduction in glycosylated hemoglobin from 9.9 ± 1.3 to 9.1 ± 1.3% (P &amp;lt; .001). Patients who responded had higher fasting C-peptide levels (P &amp;lt; .001) and shorter durations of insulin therapy (P &amp;lt; .01) than those who did not respond. Glyburide withdrawal was associated with a &amp;gt; expected deterioration in glycemic control. Patients on insulin therapy for &amp;gt; 8 yr are unlikely to benefit significantly from the addition of glyburide to their treatment regimen.
Sonographic and Scintigraphic Detection of a Bile Leak in a Post-cholecystectomy Patient Recognition of the Tail Sign
Authors: ROBERT J. RIENZO, GEORGE TYLER, DONALD E. MOREL
Journal: Clinical Nuclear Medicine (1983)

Hepatobiliary scintigraphy using Tc-99m HIDA derivates is used primarily for the diagnosis of acute cholecystitis and for demonstration of biliary tract patency. Ultrasound is usually employed for diagnosing cholelithiasis and biliary tree dilatation, as well as identifying focal lesions in the liver. These two complementary modalities are also useful in the evaluation of post-cholecystectomy patients. We present a case of a bile leak, diagnosed by these two modalities.
T Cell-Induced Late Phase Asthmatic Response in Mice
Authors: Akio Mori, Satoshi Kouyama, Akemi Abe, Miyako Yamaguchi, Yo Iijima, Chihiro Mitsui, Chiyako Oshikata, Hidenori Tanimoto, Yuma Fukutomi, Kiyoshi Sekiya, Masami Taniguchi, Yuji Maeda, Mamoru Ohtomo, Maki Hasegawa, Kazuo Akiyama, Takayuki Ohtomo, Osamu Kaminuma
Journal: Journal of Allergy and Clinical Immunology (2013)
Visualization of cardiac valve motion in man during external chest compression using two-dimensional echocardiography. Implications regarding the mechanism of blood flow.
Authors: J A Werner, H L Greene, C L Janko, L A Cobb
Journal: Circulation (1981)

Five patients who underwent cardiopulmonary resuscitation (CPR) were studied by two-dimensional echocardiography to assess valve motion. The mitral valve remained open throughout the entire compression-release cycle of CPR. The aortic valve opened during the compression phase of CPR and closed during the release phase. The pulmonic valve moved toward the closed position during the compression phase and the valve leaflets opened during release. Tricuspid valve leaflets never completely apposed, even during maximum chest compression, and they were widely open during release. Left ventricular dimensions did not change appreciably during CPR. These findings support the theory that forward blood flow during CPR depends on a generalized increase in intrathoracic pressure and not on direct compression of the heart itself. The left heart appears to act as a conduit for passage of blood, and mitral valve closure is not necessary for forward blood flow during CPR.
Intensive Therapy Preserves Insulin Secretion
Authors: Roy C. Gumpel
Journal: Annals of Internal Medicine (1998)

Letters1 December 1998Intensive Therapy Preserves Insulin SecretionRoy C. Gumpel, MDRoy C. Gumpel, MDPawcatuck, CT 06379Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-11_Part_1-199812010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I see near-identical objectives and conclusions in the Diabetes Control and Complications Trial Research Group's article [1] and writings of J.M. Brush, but the former did not cite the latter. Were Brush's studies not conducted in a different era, he could have coauthored the current paper.His studies were done at a time when there were two conflicting schools of thought about management of diabetes: one chemical, championed by the Joslin School, and one clinical, followed by Tolstoi and his group. Brush occupied center stage more than 50 years ago with his intensive therapy for residual insulin ...References1. Effect of intensive therapy on residual β-cell function in patients with type 1 diabetes in the Diabetes Control and Complications Trial. A randomized, controlled trial. The Diabetes Control and Complications Trial Research Group. Ann Intern Med. 1998; 128:517-23. Google Scholar Author, Article, and Disclosure InformationAffiliations: Pawcatuck, CT 06379 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInsulin Secretion in Type 1 Diabetes 1 December 1998Volume 129, Issue 11_Part_1Page: 913-914KeywordsExerciseGlucoseHyperglycemiaHypoglycemiaInsulinInsulin secretionInsulin signalingType 1 diabetesType 2 diabetesUrine Issue Published: 1 December 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Points from letters: Punched feature cards
Authors: R J Draper
Journal: BMJ (1976)

4) Teaching and administrative duties.(5) A "flexibility factor," so dear to the hearts of our junior colleagues, should apply equally to consultants.(6) A "continuity factor" could also be brought in for the fact that consultants, whether officially on or off duty, still carry responsibility for patients in their care and expect to be called in if anything goes wrong.The pension scheme would also need to be revised, but this is perhaps a separate matter.
The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria
Authors: Maria Staevska, Todor A. Popov, Tanya Kralimarkova, Cvetelina Lazarova, Steliana Kraeva, Dora Popova, Diana S. Church, Vasil Dimitrov, Martin K. Church
Journal: Journal of Allergy and Clinical Immunology (2010)
ENLARGEMENT OF A SPLENCULUS TO THE SIZE OF A NORMAL SPLEEN: AFTER REMOVAL OF A RUPTURED SPLEEN TEN YEARS PREVIOUSLY
Authors: W. M. Eccles, G. D. Freer
Journal: BMJ (1921)

ENLARGEMENT OF A SPLENCULUS AFTER SPLENECTOMY.rMETDHAEJ2OT1tA 515 from a consideration of those factors whicll we here discuss.At tlle same time it may be wvise to utter a word of warning against the indiscriminate and uncontrolled use of tllis powverful remedy.It is a remedy of whliclh we still have muclh too little knowledge; it is one wlhich,
Galactorrhea, Gynecomastia, and Hypothyroidism in a Man
Authors: MOHAMMED A. ARNAOUT
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 May 1987Galactorrhea, Gynecomastia, and Hypothyroidism in a ManMOHAMMED A. ARNAOUT, M.D., THOMAS L. GARTHWAITE, M.D., ARNOLD J. KRUBSACK, M.D., Ph.D., THAD C. HAGEN, M.D.MOHAMMED A. ARNAOUT, M.D.Search for more papers by this author, THOMAS L. GARTHWAITE, M.D.Search for more papers by this author, ARNOLD J. KRUBSACK, M.D., Ph.D.Search for more papers by this author, THAD C. HAGEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-779_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Galactorrhea occurs rarely in men and most cases are reported in patients with prolactin-secreting pituitary tumors (1, 2). The occurrence of hyperprolactinemia and galactorrhea in the presence of hypothyroidism is well documented in women (1, 3). We report the occurrence of galactorrhea and gynecomastia, both of which resolved after thyroxine replacement therapy, in a man with occult hypothyroidism.A 59-year-old white man with seronegative rheumatoid arthritis was referred to our endocrinology clinic for the evaluation of progressive painful swelling of both breasts that had occurred during the previous 2 months. This swelling had followed an episode of...References1. KLEINBERGNOELFRANTZ DGA. Galactorrhea: a study of 235 cases, including 48 with pituitary tumors. N Engl J Med. 1977;296:589-600. CrossrefMedlineGoogle Scholar2. FINNMOUNT JL. Galactorrhea in males with tumors in the region of the pituitary gland. J Neurosurg. 1971;35:723-7. CrossrefMedlineGoogle Scholar3. EDWARDSFORSYTHBESSER CIG. Amenorrhea, galactorrhea, and primary hypothyroidism with high circulating levels of prolactin. Br Med J. 1971;3:462-4. CrossrefMedlineGoogle Scholar4. JACOBSSNYDERUTIGERDAUGHADAY LPRW. Prolactin response to thyrotropin-releasing hormone in normal subjects. J Clin Endocrinol Metab. 1973;36:1069-73. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Medical College of Wisconsin, and Veterans Administration Medical Center Milwaukee, WI 53295 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAdenohypophyseal Function in Dogs with Primary Hypothyroidism and Nonthyroidal Illness 1 May 1987Volume 106, Issue 5Page: 779-780KeywordsEndocrinologyHypothyroidismInflammationPituitary tumorsRheumatoid arthritisThyroxine Issue Published: 1 May 1987 PDF DownloadLoading ...
Laxative induced magnesium poisoning in a 6 week old infant.
Authors: L H Alison, D Bulugahapitiya
Journal: BMJ (1990)

1982, was controlled with metformin 500 mg twice daily.At laparotomy the duodenal nodule was resected and the liver appeared clear.Histology confirmed a non-argyrophilic, non-argentophilic, trabecular carcinoid tumour which had not invaded the muscularis propria.A urinary screen for 5hydroxyindole acetic acid gave a negative result.Although carcinoid tumours are the most common primary tumour of the small intestine, duodenal carcinoids are rare.'In the case of gastric carcinoids gastrin may play a part as it appears to act as a trophic hormone.2The relation between drug induced hypergastrinaemia and carcinoids remains the subject of much debate.'Carcinoid tumours found in patients with chronic atrophic gastritis or pernicious anaemia,4 or in rats given long term H2 antagonists, appear to be confined to the gastric fundus.5Nevertheless, the occurrence of such an unusual tumour in a patient receiving long term treatment with ranitidine leads us to suspect that the two may be interrelated.Neither the manufacturer nor the Committee on Safety of Medicines is aware of any previous reports of such an association.1 Barclay I'HC, Schapira DVI.Malignant tumours of the small
Review: Current evidence shows no overall benefit of aspirin for primary prevention of cardiovascular disease in diabetes
Authors: Michael LeFevre
Journal: Annals of Internal Medicine (2010)

Source Citation De Berardis G, Sacco M, Strippoli GF, et al. Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials. BMJ. 2009;339:b4531. 19897665
Bcl-xL–inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets
Authors: Simone M. Schoenwaelder, Kate E. Jarman, Elizabeth E. Gardiner, My Hua, Jianlin Qiao, Michael J. White, Emma C. Josefsson, Imala Alwis, Akiko Ono, Abbey Willcox, Robert K. Andrews, Kylie D. Mason, Hatem H. Salem, David C. S. Huang, Benjamin T. Kile, Andrew W. Roberts, Shaun P. Jackson
Journal: Blood (2011)
Regulation of platelet-derived growth factor ligand and receptor gene expression by alpha-thrombin in vascular smooth muscle cells.
Authors: H Okazaki, M W Majesky, L A Harker, S M Schwartz
Journal: Circulation Research (1992)

Since the expression of genes for platelet-derived growth factor (PDGF)-A and PDGF beta-receptor are reciprocally regulated in vascular wall cells after balloon injury, we have investigated the ability of specific vasoactive molecules or growth factors to reproduce the injury pattern of gene expression in cultured rat smooth muscle cells (SMCs) and assessed the effect of inactivating alpha-thrombin on injury-induced expression of PDGF-A mRNA by vascular wall cells in vivo. The molecules investigated, to which vascular SMCs may be locally exposed after mechanical injury, included vasoactive factors (alpha- and beta-adrenergic agonists, serotonin, histamine, angiotensin II, and endothelin) and growth factors (PDGF-AA, PDGF-BB, basic fibroblast growth factor, insulin-like growth factor, epidermal growth factor, and alpha-thrombin). In cultured rat SMCs, only alpha-thrombin (0.1-100 nM), among these compounds, produced the pattern of transiently increased PDGF-A and decreased PDGF beta-receptor mRNA. PDGF-B chain mRNA levels remained undetectable in these cultured SMCs. The dependence of these changes in gene expression on the proteolytic activity of alpha-thrombin was shown by the interruption of altered gene expression or DNA synthesis after incubating the cultured SMCs with covalently inactivated alpha-thrombin using D-Phe-Pro-Arg chloromethyl ketone, a synthetic direct active-site irreversible inhibitor of alpha-thrombin. Continuous intravenous infusion of this synthetic antithrombin into baboons for 6 hours (100 nmol/kg per minute maintaining constant plasma levels of 3.0 +/- 0.5 microns/ml) after inducing balloon-catheter arterial injury also prevented the threefold increase in expression of PDGF-A mRNA characteristically exhibited by untreated mechanically injured vessels.(ABSTRACT TRUNCATED AT 250 WORDS)
High-resolution Fourier-Domain Optical Coherence Tomography and Microperimetric Findings After Macula-off Retinal Detachment Repair
Authors: Allison J. Smith, David G. Telander, Robert J. Zawadzki, Stacey S. Choi, Lawrence S. Morse, John S. Werner, Susanna S. Park
Journal: Ophthalmology (2008)
A major immunogen in Schistosoma mansoni infections is homologous to the heat-shock protein Hsp70.
Authors: R Hedstrom, J Culpepper, R A Harrison, N Agabian, G Newport
Journal: The Journal of Experimental Medicine (1987)

A 70,000 mol wt protein of Schistosoma mansoni was shown to be a major immunogen that invariably elicited an antibody response in infected humans. The universality of the response to this abundant antigen was confirmed in experimental animals and included the antibody response associated with the protective irradiated cercarial vaccine. We identified the 70,000 mol wt antigen as an S. mansoni homologue of the major eukaryotic heat-shock protein hsp70 by DNA sequence analysis of a cDNA insert from a lambda gt11 clone expressing the antigen and located the immunodominant epitope near the COOH-terminus of the molecule. The antigenic relationship of hsp70 to schistosome infections suggested an important role for this protein in parasite development and pathogenesis.