tbuckley/cabot-search huggingface dataset:
Where does the gene for hemochromatosis lie in relation to HLA-A? Gasparini P, Borgato L, Piperno A, Girelli D, Olivier O, Gottadi E, Roetto A, Dianzani I, Fargion S, Schinala G, Cappellini MD, Gandini G, Pignatti PF, Fiorelli G, De Sandre G, Camaschella C. Linkage analysis of 6p21 polymorphic markers and the hereditary hemochromatosis: Localization of the gene centromeric to HLA-F. Hum Mol Gene 1993;2:571–576
Authors: E Jazwinska
Journal: Hepatology (1994)
Tc-99m MDP Scintigraphy in a Case of Idiopathic Calcinosis Cutis
Authors: Anish Bhattacharya, Vikas Prasad, Eluvathingal Jose Thomas, Baljinder Singh, Bhagwant Rai Mittal
Journal: Clinical Nuclear Medicine (2005)

An 11-year-old boy presented with a 7-year history of waxing and waning papulonodular lesions on the extremities. A Tc-99m methylene diphosphonate (MDP) whole-body bone scan showed multiple areas of irregularly increased uptake in the skin and subcutaneous tissues on the posterior aspect of both lower extremities. Skin biopsy demonstrated deposition of calcium salts in the dermis, confirming a diagnosis of calcinosis cutis.
Direct Regulation of Gata3 Expression Determines the T Helper Differentiation Potential of Notch
Authors: Derk Amsen, Andrey Antov, Dragana Jankovic, Alan Sher, Freddy Radtke, Abdallah Souabni, Meinrad Busslinger, Brent McCright, Thomas Gridley, Richard A. Flavell
Journal: Immunity (2007)
Relationship Between Estrogen Levels, Use of Hormone Replacement Therapy, and Breast Cancer
Authors: Graham A. Colditz
Journal: JNCI Journal of the National Cancer Institute (1998)

We sought to determine the strength of the evidence suggesting that estrogen and postmenopausal replacement hormones play a role in the development of breast cancer. We reviewed the existing English language literature in MEDLINE on hormones and breast cancer, including reports on cell proliferation and endogenous hormone levels, as well as epidemiologic studies of the relationship between the use of postmenopausal hormones and the risk of breast cancer in women. A factor that increases the probability that cancer will develop in an individual has been defined as a cancer cause. The Hill criteria for demonstrating a link between environmental factors and disease were used to review the evidence for a causal relationship between female hormones and breast cancer. We found evidence of a causal relationship between these hormones and breast cancer, based on the following criteria: consistency, dose-response pattern, biologic plausibility, temporality, strength of association, and coherence. The magnitude of the increase in breast cancer risk per year of hormone use is comparable to that associated with delaying menopause by a year. The positive relationship between endogenous hormone levels in postmenopausal women and risk of breast cancer supports a biologic mechanism for the relationship between use of hormones and increased risk of this disease. The finding that the increase in risk of breast cancer associated with increasing duration of hormone use does not vary substantially across studies offers further evidence for a causal relationship. We conclude that existing evidence supports a causal relationship between use of estrogens and progestins, levels of endogenous estrogens, and breast cancer incidence in postmenopausal women. Hormones may act to promote the late stages of carcinogenesis among postmenopausal women and to facilitate the proliferation of malignant cells. Strategies that do not cause breast cancer are urgently needed for the relief of menopausal symptoms and the long-term prevention of osteoporosis and heart disease.
The Influence of Hypermagnesemia on Serum Calcium and Parathyroid Hormone Levels in Human Subjects
Authors: Ina N. Cholst, Susan F. Steinberg, Pamela J. Tropper, Harold E. Fox, Gino V. Segre, John P. Bilezikian
Journal: New England Journal of Medicine (1984)

We measured serum concentrations of calcium and parathyroid hormone in seven pregnant women who were receiving intravenous magnesium sulfate for the suppression of premature labor. After administration of magnesium sulfate, the mean (+/- S.E.M.) serum magnesium level rose rapidly from the normal base-line level of 2.0 +/- 0.2 mg per deciliter to 6.1 +/- 0.4 mg per deciliter (0.8 +/- 0.1 to 2.5 +/- 0.2 mmol per liter) (P less than 0.001) at 30 minutes and remained markedly elevated. Concentrations of total and ionized calcium fell gradually in all subjects from normal base-line concentrations, 8.6 +/- 0.2 and 4.4 +/- 0.1 mg per deciliter (2.2 +/- 0.1 and 1.1 +/- 0.03 mmol per liter), respectively, into the hypocalcemic range, reaching a nadir of 7.6 +/- 0.2 and 3.9 +/- 0.1 mg per deciliter (1.9 +/- 0.1 and 0.98 +/- 0.03 mmol per liter), respectively, at three hours (P less than 0.001). Parathyroid hormone levels fell rapidly in response to magnesium infusion, from 13.1 +/- 2.5 to 7.8 +/- 0.7 pg per milliliter at 30 minutes, and were significantly below base-line levels for two hours despite frank hypocalcemia. These results suggest that hypermagnesemia rapidly decreases the secretion of parathyroid hormone in vivo in human subjects and that parathyroid hormone levels remain depressed despite concomitant hypocalcemia. The results also suggest that the hypocalcemia associated with hypermagnesemia may be due in part to the suppressive effects of hypermagnesemia on parathyroid hormone secretion.
PERFORATING GASTRIC ULCER.WITH RECOVERY AFTER OPERATION.
Authors: J. J. GOODWIN
Journal: JAMA (1904)

H. K., aged 22 years, previous to March 6, 1904, never had any stomach symptoms. He occasionally used alcoholic stimulants. For his supper the evening of March 5 he ate a quantity of baked beans, and at 1 a. m., March 6, he indulged in another meal of baked beans. The second meal did not taste right and he was taken sick and vomited in a few minutes after eating it. This was followed by severe abdominal pain, and pain in both shoulders. I saw him two hours later, when he was having considerable pain, with mucus vomiting. An enema that had been administered failed to secure an action of the bowels. He was tender all over the abdomen; pulse and temperature were normal. Dr. W. P. Bowers saw the patient with me, but a positive diagnosis could not be made. Exploration was urged, and assented to by the family.
<i>Vicia faba</i> agglutinin, the lectin present in broad beans, stimulates differentiation of undifferentiated colon cancer cells
Authors: M Jordinson, I El-Hariry, D Calnan, J Calam, M Pignatelli
Journal: Gut (1999)

Dietary lectins can alter the proliferation of colonic cells. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding.To examine the effects of dietary lectins on differentiation, adhesion, and proliferation of colorectal cancer cells.Differentiation was assessed in three dimensional gels, adhesion by aggregation assay, and proliferation by 3H thymidine incorporation. The role of the epithelial cell adhesion molecule (epCAM) was studied using a specific monoclonal antibody in blocking studies and Western blots. The human colon cancer cell lines LS174T, SW1222, and HT29 were studied.The cell line LS174T differentiated in the presence of Vicia faba agglutinin (VFA) into gland like structures. This was inhibited by anti-epCAM monoclonal antibody. Expression of epCAM itself was unaffected. VFA as well as wheat germ agglutinin (WGA) and the edible mushroom lectin (Agaricus bisporus lectin, ABL) significantly aggregated LS174T cells but peanut agglutinin (PNA) and soybean agglutinin (SBA) did not. All lectins aggregated SW1222 and HT29 cells. Aggregation was blocked by the corresponding sugars. Aggregation of cells by VFA was also inhibited by anti-epCAM. VFA, ABL, and WGL inhibited proliferation of all the cell lines; PNA stimulated proliferation of HT29 and SW1222 cells. In competition studies all sugars blocked aggregation and proliferation of all cell lines, except that the addition of mannose alone inhibited proliferation.VFA stimulated an undifferentiated colon cancer cell line to differentiate into gland like structures. The adhesion molecule epCAM is involved in this. Dietary or therapeutic VFA may slow progression of colon cancer.
Familial dilated cardiomyopathy: another risk factor for anthracycline‐induced cardiotoxicity?
Authors: Maarten P. van den Berg, Karin Y. van Spaendonck‐Zwarts, Dirk J. van Veldhuisen, Jourik A. Gietema, Aleida Postma, J. Peter van Tintelen
Journal: European Journal of Heart Failure (2010)
Tools, drugs, and signals in the road from evolution to money
Authors: Federico Sanabria
Journal: Behavioral and Brain Sciences (2006)

The problem of the biology of money is twofold: It subsumes both the identification of behavioral mechanisms that account for the power of money as an incentive, and the elucidation of the phylogeny of such mechanisms. The drugs–tool distinction, as articulated by Lea &amp; Webley (L&amp;W) in their fascinating synthesis, is a welcome step toward their solution. Compared to the direct invocation of instinctual drives, however, conditioning processes provide a conceptually and empirically clearer road from evolution to money.
Immunological cross‐reactivity of hemoglobins in the Diptera familiy Chironomidae
Authors: X. BAUR, V. LIEBERS, G. MAZUR, W.‐M. BECKER, S. L. KAGEN, K. KAWAI
Journal: Allergy (1991)

Polyclonal human IgE antibodies of patients sensitized to one species of the Diptera family Chironomidae as well as polyclonal rabbit anti‐ Chi t I hyperimmune serum recognize antigenic sites present in nearly all of the 33 species of this insect family. Evolutionary distantly related genera usually show weaker antibody binding. According to the pattern of reactivity of rabbit anti‐ Chi t I ‐component III, expression of the epitopes of this molecule varies considerably in the genera Chironomus and Glyptotendipes; it appears to be almost totally absent in all other species. Of five monoclonal antibodies raised against Chi t I ‐component III, two recognize an epitope which is expressed in nearly all closely related species. Three monoclonal antibodies recognize epitopes which are expressed in only a few species of the same genus. Our results demonstrate the presence of common as well as species‐specific epitopes in chironomid hemoglobins which behave as potent inhalant allergens.
Points: Vocational training for general practice
Authors: A Demetriou
Journal: BMJ (1980)

Hyperlipidaemia advances and retreatsDr A LEWIS (London WlN 1FJ) writes: How long will it be before the hazards of eating dairy foods (23 August, p 564) are remembered with amusement like those of eating meat.This dangerous stuff (especially red meat) "caused" kidney disease, hypertension, rheumatism, and gout because it was a source of uric acid and urea, with which these conditions were thought to be associated. Drugs and rheumatoid arthritisDr JACK BOURNE (Hornchurch, Essex) writes: In his letter on the effect of corticosteroids on the manifestations of rheumatoid arthritis,
Hematology: Physiologic, Pathophysiologic, and Clinical Principles
Authors: Fred Rosner
Journal: JAMA (1976)

Within the past five years, a large number of hematology textbooks have been published. Linman's text ranks among the best. The book is somewhat shorter (1,055 pp) than its three major competitors. Wintrobe (1,896 pp), Williams (1,480 pp) and Hardisty and Weatherall (1,540 pp). The double-column format allows space for maximum information. The book is more up-to-date than Williams (1975 vs 1972) and is far cheaper ($34.95) than Hardisty and Weatherall's<i>Blood and Its Disorders</i>($89). Linman's new text is an expanded version of his earlier book<i>Principles of Hematology</i>(Macmillan Co, 1966). Remarkable is the fact that, except for the chapter on monoclonal gammopathies, the entire book was written by a single author. This is a distinct advantage, since the style of the book is uniform, and unnecessary duplication and overlap are avoided. Linman's<i>Hematology</i>is a clinically oriented reference volume, whose goal is to provide descriptions of disease
Roles, risks, and responsibilities in maternity care: trainees' beliefs and the effects of practice obstetric training.
Authors: L. F. Smith
Journal: BMJ (1992)

<h3>Objectives &amp; Background</h3> How much does alcohol contribute to the demands on the Emergency Department (ED)? York is a popular tourist destination, particularly amongst hen and stag parties. But a quarter of the resident population have previously been identified as higher risk drinkers. So therefore, how much does alcohol contribute to the pressures on York ED? Additionally, clinical coding of alcohol within the ED is anecdotally unreliable. How true is this? We therefore undertook an alcohol needs assessment within York ED looking at general demographics, reasons for attendance and evidence of alcohol linked to the attendance. We also looked at the discrepancy between how much the ED was paid for these patients by commissioners and the actual cost to the acute trust. <h3>Methods</h3> We randomly selected 1 week per quarter in 2011 and hand searched every ED record for evidence of alcohol-related attendance. We also included patients for whom it was felt alcohol was highly likely although not directly mentioned. We undertook a concordance assessment around the alcohol question and achieved 94%. <h3>Results</h3> The 4 randomly selected weeks amounted to a 5,704 patient sample, 7.2% of the total number of attendances in 2011. 9.8% of attendances were alcohol-related (553 patients) Between 21:00 and 09:00, this rose to 19.7% Alcohol was involved in 45% of mental health attendances The alcohol group was heavily over-represented in the patients removed by police (100%), refusing treatment (55%) and leaving prior to their treatment (41%) 10.3% of alcohol-related attendees remained in the ED for &gt;4hours compared with 5.9% of non-alcohol-related attendees 62.8% of alcohol-related attendees were living within the City of York 18% of all ambulance journeys were due to alcohol Although 553 patients had evidence of alcohol in their attendance, it was only coded as such in 46 computer records If these figures are extrapolated to cover the annual patient population, the discrepancy between what the commissioners pay and the true cost of these patients is £552,431 <h3>Conclusion</h3> Alcohol poses a disproportionate burden on York Emergency Department and Yorkshire Ambulance Service. With pressures on staffing, the 4 hour standard and ambulance turnaround times at an all-time high, how different would the ED be if the alcohol burden were reduced? This needs assessment fuels the argument for an 9invest to save9 attitude to reduce alcohol-related attendance.
Agiolax®Bolus in the Esophagus
Authors: T. Sauerbruch, O. Kuntzen, W. Unger
Journal: Endoscopy (1980)

Two cases of intermittent obstruction of the esophagus by the laxative Agiolax, proven by endoscopy and barium swallow, are described. The patients took an overdose of one and two tablespoons of Agiolax, respectively; they had no disorders of the esophagus. Symptoms of obstruction subsided spontaneously after 24 and 36 hours respectively.
Epigenetic Mechanisms of Depression
Authors: Eric J. Nestler
Journal: JAMA Psychiatry (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
VALUE OF THE BROMINE TEST FOR DIAGNOSIS OF PREGNANCY
Authors: G. H. Dodds
Journal: BMJ (1930)

sle wi-as 7 y-ears of age, wh-lieni she liadl a slow feverv with extreme weakness and purpura; she was confinetl to bed for miiany weeks, an1d sli(I nievel coml)letely recovered lher strength, though lhet gelneral healtil was good aild no medical attention was requliredl till slhe was, about 35 years
Pain in the Chest
Authors: Henry I. Russek
Journal: JAMA (1965)

Good medical practice requires not only the exclusion of a cardiac disorder (if none exists), but accurate diagnosis and treatment as well. Too often the "problem" patient is shuttled from one specialist to another when accurate diagnosis could have been made by careful interrogation and attention to fundamentals of examination. In the standard textbooks of cardiology, the differential diagnosis of chest pain often occupies about four pages; Dr. Wehrmacher has written 400 on the subject without exceeding the limits of concise and pertinent presentation. Moreover, his clear and refreshing style, methodical approach, and obvious talent for teaching have imparted a rare quality to this valuable work. Indeed, an expectedly tedious "dissection" of chest pain has been transformed into an absorbingly interesting, lucid, and authoritative treatise for the practicing physician. The author, in regarding the examining doctor as a detective sifting the clues, demonstrates that "solving the mystery is both a
The Asthma Control Test and Asthma Control Questionnaire for assessing asthma control: Systematic review and meta-analysis
Authors: Chun E. Jia, Hong Ping Zhang, Yan Lv, Rui Liang, Yun Qiu Jiang, Heather Powell, Juan Juan Fu, Lei Wang, Peter Gerard Gibson, Gang Wang
Journal: Journal of Allergy and Clinical Immunology (2012)
Hypertriglyceridemia Enhances Monocyte Binding to Endothelial Cells in NIDDM
Authors: Nicoline Hoogerbrugge, Anton Verkerk, Marloes L Jacobs, Pieter TE Postema, Johan F Jongkind
Journal: Diabetes Care (1996)

OBJECTIVE The mechanisms by which diabetes leads to rapidly progressive atherosclerosis are not fully understood. Adherence of monocytes to the arterial wall is an early event in the development of atherosclerotic lesions. RESEARCH DESIGN AND METHODS The binding of freshly isolated monocytes from patients with NIDDM, IDDM, and healthy control subjects to a monolayer of endothelial cells obtained from human umbilical vein was investigated. RESULTS Endothelial adherence of monocytes from normolipidemic patients with IDDM (15.8 ± 4.5%) or NIDDM (16.9 ± 4.6%) was comparable to that of monocytes from a control population (15.3 ± 3.5%). In patients with NIDDM with a serum triglyceride concentration &amp;gt; 2.5 mmol/l, the percentage of cells that adhere to endothelial cells in vitro was significantly increased (23.3 ± 3.1%). Glycemic control did not correlate with monocyte adherence. The presence of symptomatic atherosclerotic disease, age, or sex was not associated with a change in monocyte binding in vitro. CONCLUSIONS The results suggest that in NIDDM hypertriglyceridemia should be treated to reduce the high risk for atherosclerosis.
One in four multiple pregnancies at London clinic resulted from fertility treatment overseas
Authors: R. Dobson
Journal: BMJ (2009)

Fertility treatment outside the United Kingdom was responsible for more than a quarter of fertility treated multiple pregnancies (more than two embryos) seen at one UK specialist clinic.

Over 11 years 109 women were treated at a specialist multiple pregnancy clinic at University College Hospital, London. Of these, 94 (86%) were conceived with fertility treatment, 24 (26%) of them overseas ( BJOG doi:10.1111/j.1471-0528.2009.02294.x).

Reasons women gave for seeking treatment overseas included the high cost of and slow access to local treatment in the UK and the limited number …
Intussuscepted sigmoid adenocarcinoma diagnosed via endoscopic ultrasonography
Authors: D. Brenner, R. Kwon
Journal: Endoscopy (2008)

Intussusceptions are rare occurrences in which a proximal bowel segment invaginates into the distal lumen. Usually neoplastic, a lead point can be identified in 70–90 % of cases by either abdominopelvic CT (CTAP) or transabdominal ultrasonography [1]. We describe the use of endoscopic ultrasound to identify a malignant lead point in a colonic intussusception.
A likelihood method for the detection of selection and recombination using nucleotide sequences
Authors: N. C. Grassly, E. C. Holmes
Journal: Molecular Biology and Evolution (1997)

Different regions along nucleotide sequences are often subject to different evolutionary forces. Recombination will result in regions having different evolutionary histories, while selection can cause regions to evolve at different rates. This paper presents a statistical method based on likelihood for detecting such processes by identifying the regions which do not fit with a single phylogenetic topology and nucleotide substitution process along the entire sequence. Subsequent reanalysis of these anomalous regions may then be possible. The method is tested using simulations, and its application is demonstrated using the primate psi eta-globin pseudogene, the V3 region of the envelope gene of HIV-1, and argF sequences from Neisseria bacteria. Reanalysis of anomalous regions is shown to reveal possible immune selection in HIV-1 and recombination in Neisseria. A computer program which implements the method is available.
Influence of the status of the renin-angiotensin system on the effect of cilazapril on neointima formation after vascular injury in rats.
Authors: J P Clozel, R K Müller, S Roux, W Fischli, H R Baumgartner
Journal: Circulation (1993)

BACKGROUND Angiotensin converting enzyme (ACE) inhibition has been shown to prevent neointima formation after vascular injury in rats. However, clinical results evaluating restenosis after angioplasty have been negative. The goal of the present study was to evaluate the influence of the renin-angiotensin system (RAS) status on the effect of ACE inhibition on neointima formation. METHODS AND RESULTS Arterial injury was produced by ballooning the left carotid artery of rats, and neointima formation was evaluated by morphometry 2 weeks after ballooning. The effects of cilazapril were assessed in four experimental groups: normotensive rats, spontaneously hypertensive rats, hypertensive rats with a renal artery stenosis induced by clipping (two-kidney, one-clip rats), and hypertensive rats with uninephrectomy, high salt intake, and administration of deoxycorticosterone (DOCA). In parallel groups of rats, measurement of plasma renin activity was made in order to characterize (at least at the plasma level) the status of the RAS. As expected, renal artery stenosis markedly increased plasma renin activity, and DOCA decreased it to undetectable levels. Cilazapril had a marked preventive effect on neointima formation in normotensive rats, spontaneously hypertensive rats, and two-kidney, one-clip rats but was ineffective in DOCA rats. CONCLUSIONS We conclude that the status of the RAS has a major influence on the effect of cilazapril on neointima formation after vascular injury.