tbuckley/cabot-search huggingface dataset:
Abstract 1569: Antitumor activity of SR16388 against human multiple myeloma in vitro and in vivo
Authors: Wan-Ru Chao, Yihui Shi, Dominic Dinh, Carol Hou, Lidia Sambucetti
Journal: Cancer Research (2010)

Abstract Multiple myeloma (MM) is the cancer of plasma cells that derive from a clonal disorder of terminally differentiated B cells in the bone marrow. MM is generally thought to be refractory against chemotherapeutics and is incurable. Development of novel agents for the treatment of this disease is urgently needed. Previous studies have indicated that MM cells express estrogen receptors (ERs), and anti-estrogens such as ICI 182,780 and Tamoxifen have demonstrated inhibitory effects on proliferation of MM cell lines as well as on MM cells isolated from patients. MM cells also over-express proangiogenic factors such as VEGF to induce angiogenesis and support their growth and survival. At SRI International, we have developed a steroidal anti-angiogenic molecule (SR16388) that potently inhibits angiogenesis in lung and prostate cancers, and it also binds to ER-α and ER-ß with high affinities in the nanomolar range. In this study, we examined the in vitro and in vivo effects of SR16388 on growth of MM cells. In RPMI-8226 multiple myeloma cells, SR16388 inhibited cell proliferation with an IC50 value of 0.9 µM. Cell cycle analysis revealed that SR16388 arrested the RPMI-8226 cells in G2 phase. In an in vivo murine xenograft model, SR16388 significantly inhibited the growth of RPMI-8226 tumors at the dose levels of 50 and 100 mg/kg with P &amp;lt; 0.05 and P &amp;lt; 0.02 respectively in a dose dependent manner. We are currently examining the molecular effects of SR16388 that contribute to its anti-proliferative and anti-angiogenic effects on MM and other human tumor types. Based on our in vitro and in vivo data, we believe that SR16388 is a promising new therapeutic molecule for the treatment of MM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1569.
Intravenous amiodarone in cardioversion of new-onset atrial fibrillation
Authors: Jacek Cybulski, Henryk Danielewicz, Piotr Kulakowski, Andrzej Budaj, Janusz Maciejewicz, Teresa Kawka-Urbanek, Leszek Ceremuzynski
Journal: Journal of the American College of Cardiology (2003)
Sister chromatid exchange and chromosome aberration rates in a group of psoriatics before and after a course of PUVA treatment
Authors: M. J. W. FAED, L. WILLIAMSON, S. PETERSON, T. LAKSHMIPATHI, B. E. JOHNSON, W. FRAIN-BELL
Journal: British Journal of Dermatology (1980)

Blood was cultured and chromosome preparations were examined for sister chromatid exchanges and chromosome aberrations in eighteen patients receiving photochemotherapy with 8-MOP and UV-A for the treatment of psoriasis, both before starting treatment and again 6 months later. The UV-A was administered both by means of low output (irradiance: 1.1--2.25 mW/cm2) and high output (irradiance: 6.1--7.6 mW/cm2) UV-A radiation cubicles. Irrespective of the intensity of irradiation or the total dose of UV-A administered there was no evidence of chromosome damage in lymphocytes following treatment.
Prospective Multicenter Evaluation of the Direct Flow Medical Transcatheter Aortic Valve
Authors: Joachim Schofer, Antonio Colombo, Silvio Klugmann, Jean Fajadet, Federico DeMarco, Didier Tchétché, Francesco Maisano, Giuseppe Bruschi, Azeem Latib, Klaudija Bijuklic, Neil Weissman, Reginald Low, Martyn Thomas, Christopher Young, Simon Redwood, Michael Mullen, John Yap, Eberhard Grube, Georg Nickenig, Jan-Malte Sinning, Karl Eugen Hauptmann, Ivar Friedrich, Michael Lauterbach, Michael Schmoeckel, Charles Davidson, Thierry Lefevre
Journal: Journal of the American College of Cardiology (2013)
Vitamin D — Solar Rays, the Milky Way, or Both?
Authors: John G. Haddad
Journal: New England Journal of Medicine (1992)

Adequate vitamin D stores are essential for normal skeletal mineralization and growth. The vitamin is now known to be a prohormone that undergoes successive hydroxylation in the liver and kidney. The first hydroxylation yields 25-hydroxyvitamin D (25(OH)D), and the second the active hormone, 1,25-dihydroxyvitamin D (l,25(OH)2nd). This hormone travels in blood to intracellular receptors that regulate gene transcription and thereby stimulates intestinal absorption of calcium and enterocyte differentiation, regulates osteoblast and hematopoietic-cell functions, and suppresses the activity of the parathyroid gland.1 Without adequate reserves of the vitamin, insufficient l,25(OH)2D is produced, leading to poor calcium absorption, soft (undermineralized) . . .
The Presenile Dementias
Authors: Charles M. Poser
Journal: JAMA (1975)

A PROGRESSION of peculiarities that may be as harmless as the faux pas of the absent-minded professor or as tragic as the deterioration of King Lear forms the spectrum of what in its fully developed form is called dementia. Simply defined, it is intellectual disintegration. The manifestations of dementia vary considerably, reflecting the mental, social, and emotional resources of a person before his illness began. Unfortunately, it often strikes the individual at the height of his productivity. The first symptom of the condition may be a decrease in expected level of functioning, and thus the disease may be very closely tied to the patient's work or professional status. It is important to note that the symptoms that usher in the process of dementia differ little from those that occur in normal people who are exhausted, anxious, or under severe pressure. Thus, a frequent early complaint is that the patient is
TO IDENTIFY INTRINSIC RISK FACTORS FOR GROIN/HIP INJURIES AMONG ACADEMY LEVEL RUGBY UNION PLAYERS: A PROSPECTIVE COHORT STUDY
Authors: J Ryan, K McCreesh, N DeBurca
Journal: British Journal of Sports Medicine (2014)

Background Groin/Hip injuries are among the top 6 most commonly cited injuries in Rugby Union (RU). These injuries have increased significantly since 2002 moving from 16th to 4th place in the most common training injuries in 2012 RU annual audit. Objective To identify intrinsic risk factors for groin/hip injuries in an academy level RU population. Design Prospective cohort study design. Players were tested pre,mid and end season by primary investigator (PI) with team physiotherapists collecting injury data. Setting Testing was carried out in University of Limerick and two Irish RU provincial training grounds. Participants 43 players were recruited using dissemination of information leaflets and objective discussion. Inclusion criteria: Academy level RU players from 2011/2012 provincial teams, over 18 years of age, fluent in English with written consent. Exclusion criteria: Injured or non-consenting players. Risk factor assessment Hip adductor squeeze strength, hip abductor/adductor isometric strength, passive and active internal/external hip rotation ROM, hip abduction ROM, adductor flexibility, groin palpation and quality of single leg squat were examined. Anthropometric data was collected using questionnaires. Team physiotherapists recorded injuries using OSCIS grading system. Hypothesis was formulated prior to testing. Results Incidence of groin/hip injuries was 21%. Non-modifiable risk factors identified were previous injury and smaller player height. Modifiable risk factors identified included; lower isometric squeeze strength, reduced dominant leg and bilateral mean adductor flexibility, greater dominant and non-dominant hip internal rotation ROM and positive tenderness of adductor origin musculature. Conclusions This study succeeded its objective. This is of significant importance clinically due to high injury incidence leading to missed training/matches and associated costs. Future research should call on the rugby community to implement these identified risk factors in the development of a screening tool for groin/hip injuries and examine its efficiency at reducing the incidence of injury thus taking the next step in groin/hip injury prevention.
Cooperative Study of Hospital Frequency and Character of Transient Ischemic Attacks
Authors: Dennis E. Futty
Journal: JAMA (1977)

All patients (1,328) suspected of having transient ischemic attacks (TIA) who came to six institutions during a 21-month period were identified. Symptoms and symptom complexes were related to the clinical diagnoses by cross-tabulation, factor analysis, and discriminant analysis. The diagnoses obtained by the discriminant analysis program were comparable to those of reviewing clinical neurologists. Symptoms of importance in the vertebral-basilar system (VBS) were bilateral visual blurring, diplopia, ataxia, and dizziness; In either carotid system (CAS), ipsilateral monocular visual disturbance anc contralateral weakness or sensory complaints; in the left CAS, language disturbances; and in those whose ultimate diagnosis was not TIA, loss of consciousness, confusion, and bilateral leg weakness. Patients with VBS TIAs have symptoms common to conditions that are not TIA and have a greater variety of symptoms and more combinations of symptoms than CAS TIA.
Encephalopathy With Hepatorenal Alterations
Authors: Roy N. Barnett
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Jabbour et al and Winograd (<b>194</b>:1245, 1247, 1965), report cases of fatal encephalopathy in children, with degenerative changes in liver and kidneys, similar in character, and resembling others reported in recent years from Australia. In 1946 entirely similar cases were seen in Connecticut and New York following rectal suppository administration of the diallylacetic acid salt of bismuth (<b>135</b>:28, 1947). There were three deaths and one survival. The compound was withdrawn from the market at that time, and could not be responsible for the recent cases. However, the past experience may furnish a lead. It demonstrated a class of chemical compounds capable of causing toxic encephalopathy and fatty change of the liver and kidneys in very small doses, namely the allyl compounds.
Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study
Authors: Kanetee Busiah, Séverine Drunat, Laurence Vaivre-Douret, Amélie Bonnefond, Albane Simon, Isabelle Flechtner, Bénédicte Gérard, Nathalie Pouvreau, Caroline Elie, Revital Nimri, Liat De Vries, Nadia Tubiana-Rufi, Chantal Metz, Anne-Marie Bertrand, Sylvie Nivot-Adamiak, Marc de Kerdanet, Chantal Stuckens, Farida Jennane, Pierre-François Souchon, Claire Le Tallec, Christelle Désirée, Sabrina Pereira, Aurélie Dechaume, Jean-Jacques Robert, Moshe Phillip, Raphaël Scharfmann, Paul Czernichow, Philippe Froguel, Martine Vaxillaire, Michel Polak, Hélène Cavé
Journal: The Lancet Diabetes & Endocrinology (2013)
Deaths From Asphyxia Among Fishermen
Authors: Roger I. Glass
Journal: JAMA (1980)

On July 19, 1978, two crewmen aboard a shrimp trawler died and the captain was hospitalized after being exposed to a toxic atmosphere in the ship's hold. Examination of the Coast Guard records of deaths at sea since 1970 led to the identification of 11 incidents involving 32 deaths by asphyxia. All deaths occurred in the unventilated holds of ships in warm waters and during warm months of the year. Asphyxia in the unventilated holds of ships is an underrecognized hazard. We recommend that fishermen be informed of this hazard, that ships' holds be ventilated before they are entered, and that safety protocols be provided to rescuers of persons found unconscious in a ship's hold. (<i>JAMA</i>244:2193-2194, 1980)
Growth and Development of an Infant Receiving All Nutrients Exclusively by Vein
Authors: Douglas W. Wilmore
Journal: JAMA (1968)

An infant weighing 2,300 gm (5 lb 1 oz) with atresia of the small bowel from the ligament of Treitz to within 3 cm of the ileocecal junction, and partial atresia of the colon, declined postoperatively to 1,816 gm (4 lb) despite vigorous but conventional supportive care. A 30% solution containing all required nitrogen, calories, and essential nutrients was then infused continuously into the superior vena cava for 44 days when gastrointestinal dysfunction precluded enteral feeding. During the period when nutrition was given entirely intravenously, normal growth and development accompanied increases of 5.0 cm (1.9 in) in head circumference, 6.3 cm (2.5 in) in length, and 1,447 gm (3 lb 3 oz) in weight.
David G Simons
Authors: N. Stafford
Journal: BMJ (2010)

Set a record with a balloon flight 19 miles above Earth



The US Air Force’s Major David G Simons was exhausted, aching, and sweaty after 36 hours crammed in a tiny metal capsule hanging from a huge helium filled balloon 19 miles (31 km) above Earth. It was 20 August 1957, and he should have landed hours before, but dangerous thunderclouds swirling below had postponed his descent.

The capsule’s air regeneration system was not working properly, and the carbon dioxide level was high. Ground observers in radio contact noticed that the 35 year old was speaking at a quarter of normal speed.

No doubt a brave man, Simons later admitted, “At this point I was approaching panic. If I were not a physician, perhaps I would have panicked. But I knew what was causing my rising apprehension. One symptom of carbon dioxide poisoning is panic. And the terrific heat compounded that. I stopped to look at my problem as dispassionately as I could. I gave myself a short lecture.”

The balloon flight, part of the Operation Man High research programme, was a giant first step toward manned space flights. Simons had been hermetically sealed in …
Bone Scintigraphy in Costo-Iliac Impingement Syndrome
Authors: Jan L. Madsen
Journal: Clinical Nuclear Medicine (2008)

A syndrome of back pain caused by impingement of the lowest ribs against the iliac crest has been described in patients with osteoporotic vertebral fractures and loss of height of the patient. A case is presented of an 81-year-old woman with a long history of osteoporosis with compression fractures of several thoracic and lumbar vertebrae. She presented with progressive lower back pain and weight loss. Bone scintigraphy revealed increased uptake in the lower ribs on both sides compatible with the costo-iliac impingement syndrome. There were no signs of bone metastases.
The effect of relaxation and mental imagery on self-efficacy, competitive anxiety and sportive performance
Authors: Maryam Karimian, Fateme Kashefolhagh, Mohammad Sadegh Dadashi, Zahra Chharbaghi
Journal: British Journal of Sports Medicine (2010)

The purpose of this study was efficacy of relaxation training and imagery training (motivational general – mastery imagery) on self-efficacy, competitive anxiety and performance in (skate) athletes. The procedure of this study is experimental (pretest, post-test with control group). So that, 75 skate adolescence athletes in three group (relaxation training, imagery training and control group) randomly displaced. The instruments of study are self-efficacy, competitive anxiety and performance scales. For group 1 relaxation training and for group 2 imagery training applied and for group 3 not applied any training. Results of analysis of variance indicated that meaningful different between three groups in post-test scores of self efficacy, competitive anxiety and sportive performance (p&lt;0.05). That means, the scores of self efficacy and performance in group 2 (mental imagery training) higher than group 1 and in group 1 higher than group 3 (control group), and the scores of competitive anxiety in group 1 lower than group 2 and in group 2 lower than group 3.
HLA-DR typing in coeliac disease: evidence for genetic heterogeneity.
Authors: A Ellis, C J Taylor, M Dillon-Remmy, J C Woodrow, R B McConnell
Journal: BMJ (1984)

Sixty nine propositi from a family study of coeliac disease were typed for HLA-DR antigens. Sixty three (91%) were found to carry the antigen DR3, which was a significantly greater proportion (p = 9.6 X 10(-24] than among the 168 controls (26%). Concurrently 42 children with the disease were DR typed. Not only was the frequency of DR3 significantly increased in these patients (86% versus 26% in controls; p = 3.1 X 10(-12] but so also was the frequency of DR7 (patients 60%, controls 29%; p = 5.8 X 10(-4]. When those propositi whose coeliac disease presented before the age of 20 were combined with the childhood coeliac group and a comparison made between these patients and the remainder of the propositi, all of whom presented when they were older than 20, the childhood onset group had a significant excess of DR7 (p = 2.2 X 10(-3] and a significant deficiency of DR2 (p = 3.5 X 10(-3]. These findings indicate that childhood coeliac disease and adult coeliac disease are genetically heterogeneous.
The reactivity of Bw4+ HLA-B and HLA-A alleles with KIR3DL1: implications for patient and donor suitability for haploidentical stem cell transplantations
Authors: Bree A. Foley, Dianne De Santis, Els Van Beelen, Louise J. Lathbury, Frank T. Christiansen, Campbell S. Witt
Journal: Blood (2008)
Marriage and Divorce — Doctors and Advertising — Searching for the Virus
Authors: John Lister
Journal: New England Journal of Medicine (1956)

IN England and Wales in 1954, there were 27,471 divorces, compared with 4735 in 1937. This high incidence of broken marriages is a matter of concern to all who are interested in the stability of modern society, and the Royal Commission on Marriage and Divorce, appointed in 1951, has just published its report.The Commission has pointed out that the social and economic emancipation of women has enhanced the quality expected of marriage and at the same time has created new strains and added to the risk of breakdown. Nevertheless, in countries where the focal point of society is still . . .
Renal function tests: what do they mean? A review of renal anatomy, biochemistry, and physiology.
Authors: W O Berndt
Journal: Environmental Health Perspectives (1976)

Renal physiology, biochemistry, and anatomy are reviewed. For the most part, those aspects of these disciplines will be discussed which relate directly to the question of the evaluation of nephrotoxicity. In addition, emphasis is placed on those procedures and techniques which are useful in the evaluation of nephrotoxicity. A detailed discussion of histological and anatomical considerations is not given, since this is probably the least useful criterion for evaluation of renal damage. This information is intended as background for the remainder of the symposium which will be directed toward an understanding of specific nephrotoxicity phenomena.
The Adolescent Viewpoint
Authors: Tina L. Cheng
Journal: JAMA (1995)

Although most adolescents are healthy, adolescence is the age group in which mortality rates have increased most dramatically in recent decades.<sup>1,2</sup>Many engage in risky behaviors that can affect their health. Unintentional injury, homicide, and suicide are the leading causes of death for teens, and as many as one in four adolescents are at risk for substance abuse, sexually transmitted diseases, early unintended pregnancy, and school failure.<sup>3,4</sup>These preventable health problems make the availability of certain health services—including reproductive health services, diagnosis and treatment of sexually transmitted disease and human immunodeficiency virus (HIV), and mental health and substance abuse services—critically important for this age group. When these services are not accessible to youth, the result is missed opportunities for prevention. See also p 1913. Although American adolescents face major threats to their health, formidable barriers exist in seeking care. Adolescents and young adults have the lowest rate of
The causes of childhood leukaemia
Authors: Heather O Dickinson
Journal: BMJ (2005)

Delayed exposure to infection may trigger leukaemia after prenatal damage to DNA 

A bout one child in 2000 develops leukaemia before the age of 15: most cases are acute lymphoblastic leukaemia.1 Childhood leukaemia is a biologically diverse disease, so several pathways to its development are possible. All probably combine genetic susceptibility and exposure to external risk factors at a time when the child is vulnerable.

Children with Down's syndrome and certain other genetic syndromes are much more susceptible to leukaemia, but such conditions are involved in relatively few cases.2 Bigger babies3 and boys1 have a slightly higher risk.

Many external factors have been reported as associated with an increased risk of childhood leukaemia.4 Some may be causal, but some may merely be correlated with the actual cause. Other apparent associations may be due to chance or bias: researchers doing case-control studies often have difficulty selecting controls who are representative of the population. Factors are more likely to be causal if they are biologically plausible, are seen consistently in different populations, and have a dose-response relation to the risk of leukaemia.

In the 1950s a very large case-control study of childhood cancer in the United Kingdom found that radiography of a mother's abdomen during pregnancy increased her baby's risk of developing childhood leukaemia by …
Privacy in clinical information systems in secondary careCommentary: Let's discuss wider social and professional issuesCommentary: Organisational and cultural aspects are also important
Authors: Ian Denley, Martin Gardner, Rory O'Conor, Simon Weston Smith
Journal: BMJ (1999)

Lapatinib, an oral breast cancer drug, has recently been reported to be a mechanism-based inactivator of cytochrome P450 (P450) 3A4 and also an idiosyncratic hepatotoxicant. It also was suggested that formation of a reactive quinoneimine metabolite was possibly involved in mechanism-based inactivation (MBI) and/or hepatotoxicity. We investigated the mechanism of MBI of P450 3A4 by lapatinib. LC-MS analysis of P450 3A4 after incubation with lapatinib did not exhibit any peak corresponding to irreversible modifications. The enzymatic activity inactivated by lapatinib was completely restored by the addition of potassium ferricyanide. These results indicate that the mechanism of MBI by lapatinib is quasi-irreversible and mediated via metabolic-intermediate (MI) complex formation. This was verified by the increase of a signature Soret absorbance at around 455 nm. Two amine oxidation products of the metabolism of lapatinib by P450 3A4 were characterized: <i>N</i>-hydroxy lapatinib (M3) and the oxime form of <i>N</i>-dealkylated lapatinib (M2), suggesting that a nitroso or another related intermediate generated from M3 is involved in MI complex formation. In contrast, P450 3A5 was much less susceptible to MBI by lapatinib via MI complex formation than P450 3A4. Also, P450 3A5 had a significantly lower ability than 3A4 to generate M3, consistent with <i>N</i>-hydroxylation as the initial step in the pathway to MI complex formation. In conclusion, our results demonstrate that the primary mechanism for MBI of P450 3A4 by lapatinib is not irreversible modification by the quinoneimine metabolite, but quasi-irreversible MI complex formation mediated via oxidation of the secondary amine group of lapatinib.
Kaposi's sarcoma in kidney transplant recipients treated with cyclosporin
Authors: P. L. BENCINI, L. MARCHESI, T. CAINELLI, C. CROSTI
Journal: British Journal of Dermatology (1988)

We report the clinical and histological features and the course of Kaposi's sarcoma in three transplant patients treated with cyclosporin. Four months after cyclosporin treatment was stopped the lesions in all three patients had completely healed.