tbuckley/cabot-search huggingface dataset:
Management of obstructed balloon catheters.
Authors: G G Browning, L Barr, A G Horsburgh
Journal: BMJ (1984)

Failure of a balloon catheter to deflate is not uncommon and prevents its removal. Methods of overcoming the problem include traction, bursting the balloon by overinflation, dissolving it with solvents, puncturing it percutaneously with a needle, or puncturing it with a wire stylet passed through the catheter. All except the last technique have major disadvantages and are of questionable safety. Transcatheter puncture of the balloon was used in 16 patients to remove obstructed balloon catheters without any technical difficulty, distress to the patient, or complication. The procedure is safe, simple, and does not require an anaesthetic. If necessary it could be performed safely by nursing or paramedical staff without the patient having to be admitted to hospital. It is the method of choice for the management of this problem.
Terminal cancer care and patients' preference for place of death: a prospective study.
Authors: J Townsend, A O Frank, D Fermont, S Dyer, O Karran, A Walgrove, M Piper
Journal: BMJ (1990)

OBJECTIVE--To assess the preference of terminally ill patients with cancer for their place of final care. DESIGN--Prospective study of randomly selected patients with cancer from hospital and the community who were expected to die within a year. Patients expected to live less than two months were interviewed at two week intervals; otherwise patients were interviewed monthly. Their main carer was interviewed three months after the patient9s death. SETTING--District general hospital, hospices, and patients9 homes. MAIN OUTCOME MEASURE--Stated preferred place of final care; actual place of death; reason for final hospital admission for those in hospital; community care provision required for home care. RESULTS--Of 98 patients approached, 84 (86%) agreed to be interviewed, of whom 70 (83%) died during the study and 59 (84%) stated a preferred place of final care: 34 (58%) wished to die at home given existing circumstances, 12 (20%) in hospital, 12 (20%) in a hospice, and one (2%) elsewhere. Their own home was the preferred place of care for 17 (94%) of the patients who died there, whereas of the 32 patients who died in hospital 22 (69%) had stated a preference to die elsewhere. Had circumstances been more favourable 67% (41) of patients would have preferred to die at home, 16% (10) in hospital, and 15% (9) in hospice. CONCLUSION--With a limited increase in community care 50% more patients with cancer could be supported to die at home, as they and their carers would prefer.
Tumour necrosis factor alpha blockade is associated with sustained regression of carotid intima-media thickness for patients with active psoriatic arthritis: a 2-year pilot study
Authors: Lai-Shan Tam, Edmund K Li, Qing Shang, Brian Tomlinson, Martin Li, Ying-Ying Leung, Woon Pang Kuan, Lai-Wa Kwok, Tena K Li, Yaner Zhu, Emily W Kun, Gabriel Yip, Cheuk-Man Yu
Journal: Annals of the Rheumatic Diseases (2010)

We have reported that psoriatic arthritis (PsA) patients without overt cardiovascular diseases have evidence of premature atherosclerosis as indicated by an increased carotid intima-media thickness (IMT).1 Whether an increase in IMT reflects current (but reversible) inflammation of the vessel wall rather than more permanent structural vessel changes in PsA has never been assessed. We undertook a prospective, observational study to determine whether a 12-week treatment of tumour necrosis factor alpha (TNFα) blockers may reduce IMT in patients with active PsA, and whether the changes in IMT can be sustained in patients who were continued on long-term TNFα blockers.

Twenty consecutive PsA patients with active disease were recruited to receive TNFα blockers. After 12 weeks, nine patients continued (group 1) while 11 patients discontinued TNFα blockers due to financial constraints (group 2). Twenty PsA patients who were naive to TNFα blockers were recruited as controls (group 3). Patients …
An ACE in the Hole for Patients With Advanced Chronic Kidney Disease?
Authors: Meyeon Park, Chi-yuan Hsu
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction
Authors: Lian Xu, Zachary R. Hunter, Guang Yang, Yangsheng Zhou, Yang Cao, Xia Liu, Enrica Morra, Alessandra Trojani, Antonino Greco, Luca Arcaini, Marzia Varettoni, Jennifer R. Brown, Yu-Tzu Tai, Kenneth C. Anderson, Nikhil C. Munshi, Christopher J. Patterson, Robert J. Manning, Christina K. Tripsas, Neal I. Lindeman, Steven P. Treon
Journal: Blood (2013)
Intraamniotic interleukin-1 accelerates surfactant protein synthesis in fetal rabbits and improves lung stability after premature birth.
Authors: K Bry, U Lappalainen, M Hallman
Journal: Journal of Clinical Investigation (1997)

Intraamniotic infection is associated with increased IL-1 activity in amniotic fluid, increased incidence of preterm labor, and with decreased incidence of respiratory distress syndrome in infants born prematurely. We hypothesized that an elevated IL-1 in amniotic fluid promotes fetal lung maturation. On day 23 or 25 of gestation (term 31 d), either IL-1alpha (150 or 1,500 ng per fetus) or its antagonist IL-1 receptor antagonist (IL-1ra, 20 microg) was injected to the amniotic fluid sacs in one uterine horn, whereas the contralateral amniotic sacs were injected with vehicle. Within 40 h, IL-1alpha caused a dose-dependent increase in surfactant protein-A (SP-A) and SP-B mRNAs (maximally, fivefold), without affecting lung growth or increasing inflammatory cells in the lung. Both genders, and upper and lower lung lobes were similarly affected. IL-1ra did not modify SP-A, -B, or -C mRNA. IL-1 increased the intensity of staining of alveolar type II cells for SP-B, and the concentrations of SP-B, -A, and disaturated phosphatidylcholine in bronchoalveolar lavage. The dynamic lung compliance and the postventilatory expansion of lungs were increased two- to fourfold after IL-1alpha treatment. In fetal lung explants, IL-1alpha increased the expression of SP-A mRNA. IL-1 in amniotic fluid in preterm labor may promote lung maturation and thus be part of a host-defense mechanism that prepares the fetus for extrauterine life.
Local analgesic effect of endogenous opioid peptides
Authors: C. Stein, A.H.S. Hassan, K. Lehrberger, C. Stein, J. Giefing, A. Yassouridis
Journal: The Lancet (1993)

Opioids produce analgesia by interacting with local opioid receptors in peripheral inflamed tissue. This study investigated whether endogenous ligands of these receptors are present in synovia and whether such opioid peptides can inhibit pain by activation of intra-articular opioid receptors. Samples of synovium from 8 patients undergoing arthroscopic knee surgery were examined by immunohistochemistry for the presence of beta-endorphin, met-enkephalin, and dynorphin. All tissue samples showed synovitis. Inflammatory cells stained strongly for beta-endorphin and met-enkephalin but not for dynorphin. To find out whether blockade of intra-articular opioid receptors affected pain, we randomly assigned 22 patients undergoing arthroscopic knee surgery to receive naloxone (0.04 mg) intra-articularly (n = 10) or intravenously (n = 12); each patient received a placebo injection into the other site. Postoperative pain was assessed by visual analogue scale, a numerical rating scale, the McGill pain questionnaire, and supplementary analgesic consumption during the next 24 h. All pain scores were higher in the intra-articular naloxone group than in the intravenous naloxone group. The differences were significant (p < 0.05) during the first 4 h. Supplementary analgesic consumption was significantly higher in the intra-articular group (52.5 [14.0] vs 15.6 [8.0] mg diclofenac, p < 0.05). Opioid peptides are present in inflamed synovial tissue and can inhibit pain after knee surgery through an action specific to intra-articular opioid receptors. These findings expand the gate control theory of pain and suggest new approaches such as the development of peripherally acting opioid analgesics without central side-effects.
I-131 LYM-1 MONOCLONAL ANTIBODY IN THE PRETREATMENT EVALUATION AND THERAPY OF PATIENTS WITH B-CELL NON-HODGKIN'S LYMPHOMA
Authors: D. A. Podoloff, J. L. Murray, P. W. McLaughlin, D. J. Macey, F. F. Cabanillas, R. E. Wendt, W. F. Broussard
Journal: Clinical Nuclear Medicine (1997)

Podoloff, D. A.; Murray, J. L.; McLaughlin, P. W.; Macey, D. J.; Cabanillas, F. F.; Wendt, R. E.; Broussard, W. F. Author Information
<i>BJSM</i>education to improve your ECG reading skills
Authors: Babette M Pluim, Jonathan A Drezner
Journal: British Journal of Sports Medicine (2014)

The ‘ECG Learning modules’ on the BJSM Education website (http://bjsm.bmj.com/site/education/index.xhtml) will teach you to interpret ECGs so you can differentiate benign ECG changes seen in athletes from pathological patterns. Why is this important?

Sudden death from cardiac conditions is the leading cause of mortality in athletes during sport.1 Most disorders that increase risk of sudden cardiac death (SCD) can be identified by abnormal findings on a 12-lead ECG. Whether used for the diagnostic evaluation of cardiovascular-related symptoms, a family history of inheritable cardiac disease or premature SCD, or for the screening of asymptomatic athletes, ECG interpretation is …
A 35-Year-Old Woman Experiencing Difficulty With Breastfeeding, 18 Months Later
Authors: Tom Delbanco
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impaired suppressor activity in children affected by coeliac disease.
Authors: C Pignata, R Troncone, G Monaco, M Ciriaco, E Farris, G Carminati, S Auricchio
Journal: Gut (1985)

Immunoregulatory cells were enumerated in 19 coeliac disease children on a gluten free diet by means of monoclonal antibodies that define total T lymphocytes (T3), helper/inducer T cells (T4), suppressor/cytotoxic T cells (T8) and monocytes (M1), as well as by means of surface receptors for Fc fragments of IgM and IgG (T mu and T gamma, respectively). In addition, suppressor cell function was assessed in 17 coeliac disease patients by examining the ability of concanavalin-A (Con-A)-activated suppressor cells to inhibit autologous cell response to mitogenic stimulus as compared with age-matched controls. No statistically significant differences were found in the percentages of subsets defined by monoclonal antibodies between coeliac disease patients and age-matched controls, whereas coeliac disease patients had a significant decrease of the subpopulation bearing membrane receptor for Fc fragment of IgG. Mean value was 8.5% in coeliac patients versus 13.4% in age-matched controls. In the functional assay, mononuclear cells from 10 out of 17 coeliac disease patients either totally or partially failed to suppress responder cells after Con-A-activation. This defect is not related to HLA-DR status, because no difference was found between patients-HLA-matched and unmatched normal individuals. In this assay, mononuclear cells of three coeliac disease patients with low suppressor activity were able to inhibit responder cells to the same extent as controls, when indomethacin was used to block prostaglandin production in the induction phase of Con-A-activated suppressor cells. Our results suggest that an abnormality in immunoregulation may play a role in the pathogenesis of coeliac disease.
Clustering of multiallele DNA markers near the Huntington's disease gene.
Authors: M E MacDonald, S V Cheng, M Zimmer, J L Haines, A Poustka, B Allitto, B Smith, W L Whaley, D M Romano, J Jagadeesh
Journal: Journal of Clinical Investigation (1989)

Five highly informative multiallele restriction fragment length polymorphisms (RFLPs) of value for preclinical diagnosis of Huntington's disease (HD) have been genetically characterized. One RFLP was uncovered by expansion of the D4S43 locus while three others are at D4S111 and D4S115, loci defined by NotI-linking clones. The final marker, D4S125, represents a recently discovered VNTR locus. All four loci map closer to the HD gene and to the telomere than D4S10, the original linked marker for HD. In combination with two multiallele RFLPs previously identified for D4S43 and another linked locus, D4S95, these five new multiallele markers will dramatically improve the speed and accuracy of predictive testing in HD, and increase its applicability by maximizing the chances of an informative test for anyone with appropriate family structure.
Listen to me.
Authors: S. Kahtan, P. Fitton
Journal: BMJ (1993)

Kathy died 18 months ago.She was 28 years old.She had cerebral palsy and a severe learning disability from birth.When she was 4 she developed juvenile rheumatoid arthritis; at 9 she began to suffer from grand mal seizures which became progressively more difficult to control.In her teens Kathy became extremely ill with collagenous colitis.Towards the end of her life Kathy could not speak or walk, and she needed constant attention.At times her colitis was so severe that she had to be fed tiny amounts of liquid formula every 10 minutes through a nasogastric tube."There never seemed to be a suitable opportunity to explain the positive aspects of Kathy's life."Kathy's death was a tragedy to her parents.
694 MICRORNA EXPRESSION PROFILES IN LIVER TISSUES FROM RAT FED HIGH FAT/HIGH CARBOYDRATE DIET MAY HELP TO ELUCIDATE MOLECULAR PATHOGENESIS OF NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: A. Alisi, A. Masotti, L. Da Sacco, F. Piemonte, R. Devito, A. Alterio, G. Bruscalupi, S. Leoni, G.F. Bottazzo, V. Nobili
Journal: Journal of Hepatology (2009)
Randomized, Controlled Trial of Diabetic Patient Education: Improved Knowledge Without Improved Metabolic Status
Authors: Zachary T Bloomgarden, Wahida Karmally, M Jane Metzger, Milton Brothers, Charles Nechemias, John Bookman, Daniel Faierman, Fredda Ginsberg-Fellner, Elliot Rayfield, W Virgil Brown
Journal: Diabetes Care (1987)

We randomized 749 insulin-treated patients on the rolls of the Mount Sinai Medical Center Diabetes Clinic in a controlled trial of diabetic patient education; 345 agreed to participate, of whom 165 were assigned to the education group and 180 to the control group. Cognitive scores increased from 5.3 ± 1.6 to 5.8 ± 1.6 in the education group, but there was no change in the control group, whose score was 5.3 ± 1.7 before and after the intervention (P = .0073). HbA1c fell from 6.8 ± 2.1 to 6.1 ± 2.0% in the education group and from 6.6 ± 2.0 to 6.3 ± 2.0% in the control group, an insignificant difference (P = . 1995). The fasting blood glucose decreased from 223 ± 94 to 179 ± 73 mg/dl in the education group and from 199 ± 81 to 185 ± 76 mg/dl in the controls (P = .1983). Triglycerides, high- and low-density lipoprotein cholesterol, and insulin dosage also failed to show significant variation among groups.
THE INTRA-GASTRIC REAGENT CAPSULE—A SIMPLE DEVICE FOR TESTING THE GASTRIC REACTIONS.
Authors: FENTON B. TURCK
Journal: JAMA (1898)

A ready and convenient method of ascertaining the condition of the gastric secretions in disorders of the stomach has not hitherto been satisfactorily afforded by the appliances at our command. The inconveniences of the stomach-tube have caused resort to other devices, all of which have been more or less unsatisfactory, and have failed to receive general approval and adoption; the sponge tester of Spallanzani and Edinger,<sup>1</sup>Einhorn's<sup>2</sup>silver bucket, Spaeth's<sup>3</sup>pith pellets, etc., are all of them in their way imperfect in their performance, and otherwise objectionable. The tube itself is a disagreeable appliance, and in certain hysteric and nervous patients almost an impracticable one, at least without such compulsory measures as are used with the insane, so that its employment is often given up, to the doctor's discomfiture and the patient's disadvantage. It has, moreover, its actual dangers, and a very formidable list of conditions in
Recurrent SMARCA4 mutations in small cell carcinoma of the ovary
Authors: Petar Jelinic, Jennifer J Mueller, Narciso Olvera, Fanny Dao, Sasinya N Scott, Ronak Shah, Jian Jiong Gao, Nikolaus Schultz, Mithat Gonen, Robert A Soslow, Michael F Berger, Douglas A Levine
Journal: Nature Genetics (2014)
Paper-Chase
Authors: Gary L. Horowitz
Journal: JAMA (1983)

During the past three years, from terminals within Beth Israel Hospital, Boston, 3,654 persons used a computer program called Paper-Chase to search the medical literature. While performing 39,022 searches, these persons had 1,976,421 references displayed and selected 449,690 of them for printing. Throughout this period, the program underwent continual modification. Each year the number of searches increased—from 10,678 to 11,541 to 16,803. Each year the percentage of new users who were unsuccessful decreased—from 16 to 13 to 11. By the end of the third year, 549 people had completed 20 or more searches. Paper-Chase enables people to search the medical literature themselves, and thus provides a new experience in computerized bibliographic retrieval. When made available without charge in a teaching hospital, Paper-Chase is widely used. (<i>JAMA</i>1983;250:2494-2499)
Criminal Abortion: A Study in Medical Sociology
Authors: George E. Hall
Journal: JAMA (1964)

More than 25 years have elapsed since Dr. Bourne, an eminent London obstetrician, was found not guilty after having performed an abortion on a 14-year-old girl who had become pregnant after a particularly brutal rape. In this country no state has specifically legalized an abortion for pregnancy resulting from rape or incest. It is extremely likely, however, that many victims of such crimes have been aborted upon the medical, or more accurately psychiatric, opinion that the operation is necessary to preserve the patient's life. Our society tends to express vigorous condemnation of criminal abortion until confronted with a personally or socially unacceptable pregnancy. This book is not an emotional diatribe. It is, rather, an interesting and, at times, penetrating study of attitudes toward abortion—attitudes of the public, of religious groups, of physicians and medical organizations, of coroners and medical examiners, of police, of "patients," and of abortionists themselves. It reports
Recommendations on Predictive Testing for Germ Line p53 Mutations Among Cancer-Prone Individuals
Authors: Frederick P. Li, Judy E. Garber, Stephen H. Friend, Louise C. Strong, Andrea F. Patenaude, Eric T. Juengst, Philip R. Reilly, Pelayo Correa, Joseph F. Fraumeni
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Recommendations on Predictive Testing for Germ Line p53 Mutations Among Cancer-Prone Individuals Get access Frederick P. Li, Frederick P. Li Search for other works by this author on: Oxford Academic PubMed Google Scholar Judy E. Garber, Judy E. Garber Search for other works by this author on: Oxford Academic PubMed Google Scholar Stephen H. Friend, Stephen H. Friend Search for other works by this author on: Oxford Academic PubMed Google Scholar Louise C. Strong, Louise C. Strong Search for other works by this author on: Oxford Academic PubMed Google Scholar Andrea F. Patenaude, Andrea F. Patenaude Search for other works by this author on: Oxford Academic PubMed Google Scholar Eric T. Juengst, Eric T. Juengst Search for other works by this author on: Oxford Academic PubMed Google Scholar Philip R. Reilly, Philip R. Reilly Search for other works by this author on: Oxford Academic PubMed Google Scholar Pelayo Correa, Pelayo Correa Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph F. Fraumeni Joseph F. Fraumeni Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 15, 5 August 1992, Pages 1156–1160, https://doi.org/10.1093/jnci/84.15.1156 Published: 05 August 1992 Article history Received: 06 April 1992 Revision received: 05 June 1992 Accepted: 10 June 1992 Published: 05 August 1992
Exhibition pulls together images of blood over 2000 years
Authors: A. Ferriman
Journal: BMJ (2001)

An exhibition of 160 works devoted to the emotional, social, cultural, and scientific aspects of blood over the past 2000 years has opened in Frankfurt, Germany.

Using paintings, manuscripts, photographs, and engravings from museums in Britain, Austria, Germany, the United States, and Russia, it looks at how artists in different times have expressed their understanding of …
Receptor Binding of Biosynthetic Human Insulin on Isolated Pig Hepatocytes
Authors: Steen Gammeltoft
Journal: Diabetes Care (1981)

Biosynthetic human insulin (BHI) and pancreatic human insulin were compared with respect to receptor binding in a heterologous assay system: displacement of pork A14-125I-monoiodoinsulin from receptors on pig hepatocytes. The concentrations of human insulin giving half-maximal displacement were identical for both preparations, i.e., 0.5 nM. Their relative potency was 1.01 ± 0.14 (SD, N = 5), suggesting that biosynthetic and pancreatic human insulin exert the same biologic activity.