Unusual Synovial Fluid Findings in Reiter's Syndrome
Authors: Thomas J. Pekin, Theodore I. Malinin, Nathan J. Zvaifler
Journal: Annals of Internal Medicine (1967)

Article1 April 1967Unusual Synovial Fluid Findings in Reiter's SyndromeTHOMAS J. PEKIN JR., M.D., THEODORE I. MALININ, M.D., NATHAN J. ZVAIFLER, M.D.THOMAS J. PEKIN JR., M.D.Search for more papers by this author, THEODORE I. MALININ, M.D.Search for more papers by this author, NATHAN J. ZVAIFLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-4-677 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptReiter's syndrome is recognized as the symptom complex of nongonococcal urethritis, conjunctivitis, arthritis, and, frequently, mucocutaneous lesions. The clinical aspects of the syndrome have been well investigated (1, 2), but the synovial fluid changes thus far reported have revealed little other than the noninfectious, inflammatory nature of the synovitis. This paper reports two unusual findings in the synovial fluid from patients with Reiter's syndrome: hemolytic complement (C′) levels higher than those found in the synovial fluid from other types of joint diseases, and the presence of macrophages containing polymorphonuclear leukocytes.MATERIALS AND METHODSPATIENT MATERIALThe subjects of this study...References1. WEINBERGERROPESKULKABAUER HWMWJPW: Reiter's syndrome, clinical and pathologic observations. A long term study of 16 cases. Medicine (Balt.) 41: 35, 1962. CrossrefMedlineGoogle Scholar2. MONTGOMERYPOSKEBARTONFOXWORTHYBAKER MMRMEMDTLA: The mucocutaneous lesions of Reiter's syndrome. Ann. Intern. Med. 51: 99, 1959. LinkGoogle Scholar3. MALININPEKINBAUERZVAIFLER TITJHNJ: Vacuoles in synovial fluid leukocytes. Amer. J. Clin. Path. 45: 728, 1966. CrossrefMedlineGoogle Scholar4. BLOCHBUNIM KJJJ: Simple rapid and diagnostic test for rheumatoid arthritis—bentonite flocculation test. JAMA 169: 307, 1959. CrossrefMedlineGoogle Scholar5. PEKINZVAIFLER TJNJ: Hemolytic complement in synovial fluid. J. Clin. Invest. 43: 1372, 1964. CrossrefMedlineGoogle Scholar6. FOSTIROPOULOSAUSTENBLOCH GKFKJ: Total hemolytic complement (C′H50) and second component of complement (C2HU) activity in serum and synovial fluid. Arthritis Rheum. 8: 219, 1965. CrossrefMedlineGoogle Scholar7. HEDBERG H: The depressed synovial complement activity in adult and juvenile rheumatoid arthritis. Acta Rheum. Scand. 8: 289, 1965. Google Scholar8. FISHMICHAELGEWURZGOOD AJAFHRA: Immunopathologic changes in rheumatoid arthritis synovium. Arthritis Rheum. 9: 267, 1966. CrossrefGoogle Scholar9. ZVAIFLER NJ: A speculation on the pathogenesis of joint inflammation in rheumatoid arthritis. Arthritis Rheum. 8: 289, 1965. CrossrefMedlineGoogle Scholar10. MCCARTY DJ: Crystal-induced inflammation: syndromes of gout and pseudogout. Geriatrics 18: 467, 1963. MedlineGoogle Scholar11. SCHACHTERBARNESJONESENGLEMANMEYER JMGJPEPKF: Bedsonia isolation studies in human arthritis. Arthritis Rheum. 9: 538, 1966. Google Scholar12. AMORCOSTEDELBARRE BFF: Sur l'origine virale possible du syndrome oculo-uréthrosynovial. Presse Med. 73: 1825, 1965. MedlineGoogle Scholar13. NORTONLEWISZIFF WLDM: Light and electron microscopic observations on the synovitis of Reiter's syndrome. Arthritis Rheum. 9: 747, 1966. CrossrefMedlineGoogle Scholar14. TAICHMANURIUHARAMOVAT NSTHZ: Ultrastructural alterations in the local Schwartzman reaction. Lab. Invest. 14: 2160, 1965. MedlineGoogle Scholar15. SPEIRSSPEIRS RSEE: Cellular localization of radioactive antigen in immunized and non-immunized mice. J. Immun. 90: 561, 1963. MedlineGoogle Scholar16. MURAMATSUMORITASOHMURA STY: Cellular kinetics of phagocytic cells in immunized x-irradiated mice. J. Immun. 95: 1134, 1965. MedlineGoogle Scholar17. FISHMANADLER MFL: Antibody formation initiated in vitro. II. Antibody synthesis in x-irradiated recipients of diffusion chambers containing nucleic acid derived from macrophages incubated with antigen. J. Exp. Med. 117: 595, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS J. PEKINJR., M.D.; THEODORE I. MALININ, M.D.; NATHAN J. ZVAIFLER, M.D.Affiliations: Washington, D. C.From the Department of Medicine, Division of Rheumatic Diseases and Department of Research Pathology, Georgetown University Medical Center, Washington, D. C.This study was supported in part by grants AM-O 5042 and AM-O 5140, the U. S. Public Health Service, Washington, D. C., and funds from The Arthritis Foundation of Metropolitan Washington and from the National Foundation.This paper was presented in part at the XI International Congress of Rheumatology, Mar del Plata, Argentina, December 7, 1965.Requests for reprints should be addressed to Thomas J. Pekin, Jr., M.D., Division of Rheumatic Diseases, Georgetown University Medical Center, 3800 Reservoir Rd., N.W., Washington, D. C. 20007. 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Clinical, synovial fluid, and biopsy studiesExamination of Synovial FluidImmunoelectrophoretic assay for synovial fluid C3 with correction for synovial fluid globulinJoint fluid cytology in Reiter's disease.Heberden Society: combined meeting with the British Orthopaedic Research Society, London, March, 1978 [abstracts]Laboratory diagnosis of rheumatoid arthritis. Prospective study of 85 patients.Morbus ReiterReiter's Syndrome in Childhood: A Sequel to Traveler's DiarrheaEffects of prednisolone in an experimental model of arthritis in the rabbit.Nineteenth rheumatism review. Part-IIIJoints and Joint FluidMorphologic studies of mononuclear cells of human synovial fluid 1 April 1967Volume 66, Issue 4 Page: 677-684 Keywords Arthritis Conjunctivitis Lesions Medical services Neutrophils Reactive arthritis Rheumatic fever Rheumatology Synovial fluid ePublished: 1 December 2008 Issue Published: 1 April 1967 PDF downloadLoading ...