tbuckley/cabot-search huggingface dataset:
Secondary syphilis: a clinico-pathological review
Authors: E. ABELL, R. MARKS, E.WILSON JONES
Journal: British Journal of Dermatology (1975)

The histological appearances found in biopsies from fifty-seven patients with secondary syphilis have been correlated with the clinical morphology of the eruptions. Considerable variation of histological pattern was encountered, and the frequency with which some of the classically described changes were found to be absent or inconspicuous is stressed. Of particular interest were the findings that, in nearly one-quarter of the biopsies, plasma cell infiltration was either absent or very sparse, and that vascular damage was seen in less than half. Where present, the vessel changes were almost entirely confined to swelling of the endothelial cells. Proliferation of the endothelial cells was most uncommon. The epidermis was very frequently involved in the inflammatory process. Exocytosis, spongiosis, parakeratosis, and acanthosis were the most frequent changes. No consistent histological difference between papular and papulo-squamous lesions could be found but macular lesions demonstrated more superficial and less intense dermal infiltration as well as less severe epidermal involvement. In late secondary lesions, the infiltrate became granulomatous, but in other respects the duration of the exanthem could not be correlated with the pathology. The differential diagnosis from pityriasis lichenoides and other inflammatory dermatoses is discussed and the value of histopathology in the diagnosis of secondary syphilis is emphasized.
Elizabeth Pryce-Jones
Authors: A. South
Journal: BMJ (2014)

Elizabeth Pryce-Jones (“Liz,” but known to her colleagues as “PJ”) had a larger than life, charismatic personality. She showed fierce loyalties, held strong opinions, delighted in the company of children and dogs, and had a passion for medicine.

A great extrovert, inclined to flamboyance of dress, she enlivened any gathering with an inexhaustible fund of stories and a keen sense of humour.

Paediatric practice occupied most of her working life. She was an astute diagnostician with a somewhat unconventional view of medicine. Her referral letters were legendary and would by today’s standards be …
Beclomethasone Dipropionate Steroid Aerosol in Treatment of Perennial Allergic Asthma in Children
Authors: H. M. Brown, G. Storey
Journal: BMJ (1973)

Thirty-one chronic perennial asthmatics aged from 2½ to 16 years were treated with beclomethasone dipropionate pressurized aerosols for up to 20 months. Of these, 16 patients dependent on oral corticosteroid or corticotrophin for up to 11 years were successfully transferred to this treatment, with one exception. Steroid withdrawal symptoms were slight. Loss of weight, disappearance of Cushingoid features, and resumption of growth indicated lack of systemic side effects. Fifteen others inadequately controlled on bronchodilators or disodium cromoglycate, were also effectively treated, and no clinical evidence of adrenal suppression was noted.
Familiarity breeds contempt
Authors: T. Dalrymple
Journal: BMJ (2008)

In his essay How the Poor Die , published in 1946, George Orwell describes his admission to a hospital in Paris, which he coyly calls Hopital X, in 1929, when he had pneumonia. He is treated unceremoniously, with cupping and a mustard plaster; the people applying these useless treatments do not bother with such refinements as informed consent—or indeed consent of any kind. The patients are lucky to get what they are given.

Orwell relates how the doctors and medical students exchange hardly a word with the patients and certainly do not acknowledge their common humanity. The students tremble with excitement as …
Another AIDS Report Ready
Authors: Phil Gunby
Journal: JAMA (1988)

ANOTHER STUDY GROUP report on acquired immunodeficiency syndrome (AIDS)—from a joint committee of the Institute of Medicine and National Academy of Sciences—now is available for purchase (National Academy Press, [202] 334-3313). Entitled<i>Confronting AIDS: Update 1988</i>, it is the follow-up to a report issued 21 months earlier and is critical of what it calls "the absence of strong federal leadership" in combating AIDS, although it praises the work of Surgeon General C. Everett Koop, MD. The report calls for a national commission on AIDS and human immunodeficiency virus (HIV). The Presidential Commission on the HIV Epidemic (see accompanying article) is scheduled to be dissolved. The report also says more than $1 billion may be needed annually to control spread of HIV infection. The eight-member committee has been chaired by Theodore Cooper, MD, Upjohn Company, Kalamazoo, Mich.
Ethical Issues in the Implantation of the Total Artificial Heart
Authors: F. Ross Woolley
Journal: New England Journal of Medicine (1984)

IN June 1980 researchers at the University of Utah requested that the institutional review board approve a protocol to implant a total artificial heart in a living patient. In our experience, never has a request for a single experimental protocol raised so many ethical questions. The culmination of the efforts of the review board and the research surgical team to develop a process that would adequately inform the patient and to protect his or her rights occurred on December 2, 1982, with the implantation of a total artificial heart in Dr. Barney B. Clark.The application to an institutional review . . .
Tc-99m HMPAO Tomography Using a Three- Headed SPECT System Equipped with Lead Fanbeam Collimators
Authors: R DIERCKX, A DOBBELEIR, J J MARTIN, P P DE DEYN
Journal: Clinical Nuclear Medicine (1993)

The authors present oblique, coronal, and sagittal tomographic slices of a normal Tc-99m HMPAO study. In addition, some major topographic reference points are given. The images shown demonstrate the high spatial resolution (FWHM 7.3 mm) obtained with a three-headed rotating SPECT system, equipped with lead fanbeam collimators.
Assessment of Asymptomatic Coronary Artery Disease in Apparently Uncomplicated Type 2 Diabetic Patients
Authors: Carmine Gazzaruso, Adriana Garzaniti, Stefano Giordanetti, Colomba Falcone, Emanuela De Amici, Diego Geroldi, Pietro Fratino
Journal: Diabetes Care (2002)

OBJECTIVE—In patients with uncomplicated diabetes, there is low probability of finding significant coronary artery disease (CAD) by noninvasive tests. Therefore, screening for its presence is not justified, and it is important to find reliable predictors of silent CAD to identify patients with uncomplicated diabetes for further screening. The relationship between lipoprotein(a) [Lp(a)], apolipoprotein(a) [apo(a)] polymorphism, and silent CAD has never been studied. We investigated the association of Lp(a) and apo(a) polymorphism with angiographically documented asymptomatic CAD in type 2 diabetic patients without evident complications. RESEARCH DESIGN AND METHODS—A total of 1,323 diabetic patients without any clinical and electrocardiographic evidence of CAD were evaluated. Of 121 patients with highly positive results of exercise electrocardiography (ECG) (n = 30) or positive results on exercise thallium scintigraphy (n = 91), 103 subjects showed angiographically documented CAD (CAD group). Of 1,106 patients with negative results on exercise ECG, 103 subjects without CAD (NO CAD group) were selected and matched by age, gender, and duration of diabetes to patients in the CAD group. In patients in the NO CAD group, results of exercise ECG, 48-h ambulatory ECG, and stress echocardiography were negative for CAD. RESULTS—The CAD group had higher Lp(a) levels (21.7 ± 17.7 vs. 15.2 ± 19.0 mg/dl; P = 0.0093) than the NO CAD group, and a percentage of subjects had at least one small apo(a) isoform (68.9 vs. 29.1%; P = 0.0000) higher than the NO CAD group. Logistic regression analysis showed that apo(a) phenotypes (odds ratio [OR] 8.13, 95% CI 3.65–21.23), microalbuminuria (5.38, 2.44–11.88), smoking (2.72, 1.31–5.64), and Lp(a) levels (2.41, 1.15–5.03) were predictors of asymptomatic CAD. CONCLUSIONS—Our investigation reports the first evidence of an independent association of Lp(a) and apo(a) polymorphism with asymptomatic CAD. This suggests that Lp(a) levels and apo(a) phenotypes could be used together with other risk factors as markers of asymptomatic CAD in patients with diabetes.
Platelet Sequestration in Widespread Pulmonary Hemangiolymphangiectasia Demonstration by lndium-111 Labeled Platelets
Authors: SUNG M. KIM, CHAN H. PARK, MATHEW L. THAKUR
Journal: Clinical Nuclear Medicine (1987)

A thrombocytopenic patient with pulmonary hemangiolymphangiectasia proven by biopsy, was studied for platelet sequestration with ln-111-labeled autologous platelets. The 24-hour scan showed diffuse increased uptake throughout both lung fields, indicating platelet sequestration by the diffuse pulmonary hemangiolymphangiectasia.
Apolipoprotein &amp;isin;4 and coronary artery disease
Authors: M.N. Payne, E. Green, M.R. Walker, J.M. Beattie, R.G. Murray, A.F. Jones, JeanP. O'Malley, D.Roger Illingworth, P.De Knijff, H. Jansen, K.I. Lie, L.M. Havekes
Journal: The Lancet (1992)
Albumin transport characteristics of rat aorta in early phase of hypertension.
Authors: A Tedgui, R Merval, B Esposito
Journal: Circulation Research (1992)

The effects of early-stage hypertension on the macromolecular transport characteristics of the aorta have been investigated in rats 1 week after the ligature of the abdominal aorta between the two renal arteries. The animals were left untreated or treated for 1 week with an angiotensin converting enzyme inhibitor (enalapril, 6 mg/kg per day). Blood pressure of a subgroup of hypertensive rats was acutely lowered to a normal level by injection of enalaprilat (1.5 mg/kg) at the time of the experiment. 131I-Albumin and 125I-albumin were injected 90 minutes and 5 minutes, respectively, before the rats were killed. The transmural distribution of the relative tissue concentrations across the wall was obtained using a serial frozen-section technique. Short-term albumin uptake permitted calculation of apparent endothelial permeability coefficients, and 90-minute uptake was used to estimate the steady-state albumin distribution within the media. The effect of early-stage hypertension on the characteristics of the arterial macromolecular transport depended on the aortic site; the ascending aortic arch appeared not to be affected. In the thoracic and abdominal aorta, the endothelial permeability coefficients increased significantly in hypertensive rats. This increase was not a direct effect of the arterial pressure, since the values were not significantly different when the pressure was acutely normalized. The 90-minute albumin concentration in the media was enhanced in hypertensive rats and returned to the normal value by acutely lowering the blood pressure, indicating that the increase observed in hypertensive rats resulted from a direct effect of pressure, possibly increased pressure-driven convection and/or pressure-induced stretching of the wall. Treatment by angiotensin converting enzyme inhibitor prevented hypertension and protected against its effects in hypertensive animals.
Cost-Effectiveness of Aspirin Treatment in the Primary Prevention of Cardiovascular Disease Events in Subgroups Based on Age, Gender, and Varying Cardiovascular Risk
Authors: Jacoba P. Greving, Erik Buskens, Hendrik Koffijberg, Ale Algra
Journal: Circulation (2008)

Background— Aspirin is effective for the primary prevention of cardiovascular events, but it remains unclear for which subgroups of individuals aspirin is beneficial. We assessed the cost-effectiveness of aspirin separately for men and women of different ages with various levels of cardiovascular disease risk. Methods and Results— A Markov model was developed to predict the number of cardiovascular events prevented, quality-adjusted life-years, and costs over a 10-year period. Event rates were taken from Dutch population data, and the relative effectiveness of aspirin was taken from a gender-specific meta-analysis. Sensitivity analyses and Monte Carlo simulations were conducted to evaluate the robustness of the results. In 55-year-old persons, aspirin prevented myocardial infarctions in men (127 events per 100 000 person-years) and ischemic strokes in women (17 events per 100 000 person-years). Aspirin implies a net investment and a quality-adjusted life-year gain in men 55 years of age; the incremental cost-effectiveness ratio was 111 949 euros per quality-adjusted life-year (1 euro=$1.27 as of June 2007). Aspirin was cost-effective for 55- and 65-year-old men with moderate cardiovascular risk and men 75 years of age (10-year cardiovascular disease risk &gt;10%). Conversely, aspirin was beneficial for women 65 years of age with high cardiovascular risk and women 75 years of age with moderate cardiovascular risk (10-year cardiovascular disease risk &gt;15%). Results were sensitive to drug treatment costs, effectiveness of aspirin treatment, and utility of taking aspirin. Conclusions— Aspirin treatment for primary prevention is cost-effective for men with a 10-year cardiovascular disease risk of &gt;10% and for women with a risk of &gt;15%. This occurs much later in life for women than men. Therefore, opportunities for the primary prevention of aspirin seem limited in women, and a differentiated preventive strategy seems warranted.
Violaceous Plaques and Breast Tenderness in a 71-Year-Old Breast Cancer Survivor
Authors: Sarah Yagerman, Melissa Pulitzer, Philip Spencer, Ashfaq Marghoob
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Lupus-like autoimmune syndrome after levodopa and benserazide.
Authors: G Massarotti, E Cassi, A Passaleva
Journal: BMJ (1979)

introduction of 100 U/ml insulin is difficulty in measuring small doses, but this does not seem to be a problem with modern disposable syringes, even though it might be with the current British Standard glass syringe.Twenty (51),,) patients had previously
Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4
Authors: Jianlin Chen, John R. Hartono, Reji John, Michael Bennett, Xin Jin Zhou, Yanxia Wang, Qingqing Wu, Pamela D. Winterberg, Glenn T. Nagami, Christopher Y. Lu
Journal: Kidney International (2011)
Hyperprolactinemia, Galactorrhea, and Atenolol
Authors: Shih-Tseng Lee
Journal: Annals of Internal Medicine (1992)

Letters15 March 1992Hyperprolactinemia, Galactorrhea, and AtenololShih-Tseng Lee, MDShih-Tseng Lee, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-6-522_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Hyperprolactinemia and galactorrhea have been induced by various drug preparations (1-5). A computer search of the literature uncovered no report of such a complication induced by atenolol, and we therefore report this case.A 38-year-old woman was found to have essential hypertension in July 1988. Her systolic blood pressures were between 180 and 150 mm Hg and her diastolic pressures were between 110 and 120 mm Hg before the administration of antihypertensive medication. Her menarche was at 15 years of age, and her menstrual history was normal. She had not received any regular medication before this time....References1. BoydReichlinTurskoy ASR. Galactorrhea-ammenorrhea syndrome: diagnosis and therapy. Ann Intern Med. 1977;87:165-75. LinkGoogle Scholar2. AonoShiojiKinugasa TTT. Clinical and endocrinological analyses of patients with galactorrhea and menstrual disorders due to sulpiride or metoclopramide. J Clin Endocrinol Meta. 1978;47:675-80. CrossrefGoogle Scholar3. GluskinStrasbergShah LBJ. Verapamil-induced hyperprolactinemia and galactorrhea. Ann Intern Med. 1981;95:66-7. LinkGoogle Scholar4. FearringtonRandRose ECJ. Hyperprolactinemia-galactorrhea induced by verapamil. Am J Cardiol. 1983;51:1466-7. CrossrefMedlineGoogle Scholar5. GioiaAsnis PG. Serial plasma prolactine levels in neuroleptic-induced galactorrhea: a case report. J Clin Psychiatry. 1988;49:29-31. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Shih-Tseng Lee, MDAffiliations: Taipei Municipal Chung Hsaio Hospital Nankang, Taipei Taiwan, Republic of China PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBeta-adrenoceptor antagonistsDrugs Used to Treat Hypertension, Heart Failure, and Angina PectorisENDOCRINE AND METABOLIC ADVERSE EFFECTS OF NON-HORMONAL AND NON-METABOLIC DRUGSAtenolol-Induced Breast Pain in a Woman with HypertensionBeta-adrenoceptor antagonistsβ-Adrenoceptor antagonists and antianginal drugsAtenolol 15 March 1992Volume 116, Issue 6Page: 522-522KeywordsBlood pressureComputersDrugsHypertensionMenarche ePublished: 1 December 2008 Issue Published: 15 March 1992 PDF downloadLoading ...
IgE antibodies against bovine serum albumin in a case of eosinophilic gastroenteritis
Authors: J. Verdaguer, M. Corominas, J. Bas, A. Valls, M. Mestre, A. Romeu, L. Gonzalez, E. Massip, E. Buendia
Journal: Allergy (1993)

Eosinophilic gastroenteritis is a disease characterized histologically by an eosinophilic infiltration of the gut. The cause of this disease remains unclear, although both food allergy and food intolerance have been implicated in its pathogenesis. We report the case of a 22‐year‐old man in whom gastrointestinal symptoms first appeared in childhood, with involvement of mucosa and muscularis layers of stomach and bowel. He presented high IgE blood levels, and his prick test was positive to bovine, pig, and lamb sera. Immunoblots from calf, pig, and lamb sera, incubated with the patient's serum and revealed by autoradiography, demonstrated the presence of a 65‐kDa protein band that was recognized by IgE antibodies but not by IgG. This band corresponded to bovine serum albumin, while IgE did not show reactivity with human albumin. These data suggest a possible role for IgE‐mediated hypersensitivity mechanisms in the pathogenesis of eosinophilic gastroenteritis.
ETA Receptor Blockade Induces Tubular Cell Proliferation and Cyst Growth in Rats with Polycystic Kidney Disease
Authors: Berthold Hocher, Philipp Kalk, Torsten Slowinski, Michael Godes, Alexander Mach, Sophia Herzfeld, Doreen Wiesner, Petra Clara Arck, Hans-H. Neumayer, Benno Nafz
Journal: Journal of the American Society of Nephrology (2003)

ABSTRACT. Tissue concentrations of ET-1 are markedly elevated in the kidneys of Han:Sprague-Dawley (Han:SPRD) rats, a model of human autosomal dominant polycystic kidney disease (ADPKD). This study analyzed whether disease progression might be attenuated by endothelin receptor antagonists. Heterozygous Han:SPRD rats received an ETA receptor antagonist (LU 135252), a combined ETA/ETB receptor antagonist (LU 224332), or placebo for 4 mo. Glomerulosclerosis, protein excretion, and GFR remained unchanged, whereas interstitial fibrosis was enhanced by both compounds. BP was not reduced by both compounds in Han:SPRD rats. Renal blood flow (RBF) decreased in ADPKD rats treated with the ETA receptor antagonist. Long-term ETA receptor blockade furthermore increased markedly the number of renal cysts (ADPKD rats, 390 ± 119 [cysts/kidney section ± SD]; LU 135252-treated APKD rats, 1084 ± 314; <i>P</i> &lt; 0.001), cyst surface area (ADPKD rats, 7.97 ± 2.04 [% of total section surface ± SD]; LU 135252-treated ADPKD rats, 33.83 ± 10.03; <i>P</i> &lt; 0.001), and cell proliferation of tubular cells (ADPKD rats, 42.2 ± 17.3 [BrdU-positive cells/1000 cells]; LU 135252-treated ADPKD rats, 339.4 ± 286.9; <i>P</i> &lt; 0.001). The additional blockade of the ETB receptor attenuated these effects in Han:SPRD rats. Both endothelin receptor antagonists had no effect on BP, protein excretion, GFR, and kidney morphology in Sprague-Dawley rats without renal cysts. It is concluded that ETA receptor blockade enhances tubular cell proliferation, cyst number, and size and reduces RBF in Han:SPRD rats. This is of major clinical impact because endothelin receptor antagonists are upcoming clinically used drugs. E-mail: berthold.hocher@charite.de
Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels
Authors: Kumpei Tanisawa, Hirokazu Taniguchi, Xiaomin Sun, Tomoko Ito, Zhen-Bo Cao, Shizuo Sakamoto, Mitsuru Higuchi
Journal: Metabolism (2014)
FORCIBLE ALVEOLAR EXPANSION IN THE TREATMENT OF CONSUMPTION.
Authors: W. H. WEAVER
Journal: JAMA (1895)

In the search for a cure for this most deadly of diseases, it seems that experimentation has been directed entirely toward the discovery of some wonderful specific, (to the exclusion of the simple truths of physics,anatomy, physiology and pathology). All the energies of the profession and of manufacturing chemists have been spent in the vain hope of finding this specific,—to their great pecuniary advantage. Now that the specific hunters in Germany and elsewhere have about lost themselves in the mazes of organic chemistry, it might be profitable to work over some old knowledge in these branches, which has been at a discount for some time past. A classic paper on this subject was read in the Philadelphia County Medical Society, by Dr. Thos. J Mays, and appeared in the<i>New York Medical Journal</i>, March 10, 1888, entitled, "Apex Expansion vs. Pure Air in Pulmonary Consumption." Concerning the cure of consumption,