Another Side to Statin-Related Side Effects
Authors: Hans Knoblauch
Journal: Annals of Internal Medicine (2010)

Letters6 April 2010Another Side to Statin-Related Side EffectsHans Knoblauch, MD, Verena Schoewel, MD, Adrian Rosada, MD, Simone Spuler, MD, and Wolfram Kress, PhDHans Knoblauch, MDFrom Charité University Medicine, 13125 Berlin, Germany, and Julius-Maximilian University, 97070 Würzburg, Germany., Verena Schoewel, MDFrom Charité University Medicine, 13125 Berlin, Germany, and Julius-Maximilian University, 97070 Würzburg, Germany., Adrian Rosada, MDFrom Charité University Medicine, 13125 Berlin, Germany, and Julius-Maximilian University, 97070 Würzburg, Germany., Simone Spuler, MDFrom Charité University Medicine, 13125 Berlin, Germany, and Julius-Maximilian University, 97070 Würzburg, Germany., and Wolfram Kress, PhDFrom Charité University Medicine, 13125 Berlin, Germany, and Julius-Maximilian University, 97070 Würzburg, Germany.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-7-201004060-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Millions of persons take statins to reduce cardiovascular risk, and about 5% of those who take statins develop skeletal muscle symptoms and increased creatine kinase levels (1). A variant in the gene SLCO1B1 increases susceptibility for this side effect by 5-fold (2). We reasoned that variants in other genes could occur in patients who were referred to us because of increased levels of creatine kinase and muscle pain or cramps.Objective: To describe 3 patients in whom statin treatment unmasked an underlying muscle disorder.Case Report: A 70-year-old salesman with no history of skeletal muscle disorders received simvastatin for ...References1. Joy TR, Hegele RA. Narrative review: statin-related myopathy. Ann Intern Med. 2009;150:858-68. [PMID: 19528564] LinkGoogle Scholar2. Link E, Parish S, Armitage J, Bowman L, Heath S, Matsuda F, et al; SEARCH Collaborative Group. SLCO1B1 variants and statin-induced myopathy—a genomewide study. N Engl J Med. 2008;359:789-99. [PMID: 18650507] CrossrefMedlineGoogle Scholar3. Day JW, Ranum LP. Genetics and molecular pathogenesis of the myotonic dystrophies. Curr Neurol Neurosci Rep. 2005;5:55-9. [PMID: 15676109] CrossrefMedlineGoogle Scholar4. Ranum LP, Cooper TA. RNA-mediated neuromuscular disorders. Annu Rev Neurosci. 2006;29:259-77. [PMID: 16776586] CrossrefMedlineGoogle Scholar5. Dolley G, Lamarche B, Després JP, Bouchard C, Pérusse L, Vohl MC. Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study. Mol Genet Metab. 2009;97:149-54. [PMID: 19329342] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Charité University Medicine, 13125 Berlin, Germany, and Julius-Maximilian University, 97070 Würzburg, Germany.Note: Drs. Knoblauch and Schoewel contributed equally.Grant Support: By the German Research Foundation (KFO 192).Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNarrative Review: Statin-Related Myopathy Tisha R. Joy and Robert A. Hegele Correction: Another Side to Statin-Related Side Effects Metrics Cited ByStatin-Associated Myopathy: Emphasis on Mechanisms and Targeted TherapyDiagnostik und Therapie von statinassoziierten MuskelsymptomenStatin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogueNeuromuscular Complications of Statin TherapyStatin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle ComponentsCorrection: Another Side to Statin-Related Side EffectsThe role of vitamin D and SLCO1B1 gene polymorphism in statin-associated myalgias 6 April 2010Volume 152, Issue 7Page: 478-479KeywordsConnective tissueElectrophysiological techniquesHypercholesterolemiaMusclesMyalgiaMyotonic dystrophyProteinsSkeletal musclesStatins ePublished: 6 April 2010 Issue Published: 6 April 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...