tbuckley/cabot-search huggingface dataset:
Soft filamentous woven polyester arterial prosthesis from China
Authors: Rao Tian-Jian, Pan Chin, Robert Guidoin, Daniel Marceau, Paul-Emile Roy, Martin King, Brigitta Badour, Rui Jusheng, Cheng Haimin, Li Cilan, Qian Xiaoping, Lin Chenhua
Journal: Biomaterials (1991)
TCT-165 Evaluation of Long-term Vascular Responses to Fluorocopolymer coated Self-Expanding low-dose Paclitaxel-eluting Stent in Porcine Ilio-femoral Model
Authors: Dongming Hou, Barbara Huibregtse, William Stoffregen, Gordon Kocur, Cory Hitzman, Elizabeth Stejskal, John Heil, Keith Dawkins
Journal: Journal of the American College of Cardiology (2012)
Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism
Authors: Huazhang An, Hongmei Xu, Minghui Zhang, Jun Zhou, Tao Feng, Cheng Qian, Runzi Qi, Xuetao Cao
Journal: Blood (2005)
Spine-Related Expenditures and Self-reported Health Status
Authors: John Ratliff
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Staphylococcus aureus Leukotoxin ED Targets the Chemokine Receptors CXCR1 and CXCR2 to Kill Leukocytes and Promote Infection
Authors: Tamara Reyes-Robles, Francis Alonzo, Lina Kozhaya, D. Borden Lacy, Derya Unutmaz, Victor J. Torres
Journal: Cell Host & Microbe (2013)
Inhibitory effect of pyruvate on release of glutathione and swelling of rat heart mitochondria
Authors: A. Bindoli, E. Barzon, M.P. Rigobello
Journal: Cardiovascular Research (1995)

Pyruvate prevents the permeability transition of rat heart mitochondria induced by the system calcium ions + phosphate or by the dithiol reagent phenylarsenoxide and measured as swelling. Since swelling induced by the latter is relieved by the dithiol 2,3-dimercaptopropanol (BAL), it is inferred that the effect of pyruvate might be mediated by the reduction of lipoic acid. In isolated mitochondria, pyruvate also exerts a protective effect when calcium + phosphate-induced swelling is exacerbated by hypoxic conditions. These results agree with our previous observations that pyruvate markedly prevents the loss of cytosolic and mitochondrial glutathione after ischemia or ischemia followed by reperfusion.
Noninvasive evaluation of exercise training in college-age men.
Authors: T D Adams, F G Yanowitz, A G Fisher, J D Ridges, K Lovell, T A Pryor
Journal: Circulation (1981)

The purpose of this study was to assess noninvasively the effects of intense aerobic training on cardiac structure and function in a group of healthy, college-age men (25 experimental and 11 control, mean age 22 years). Echocardiographic, electrocardiographic (ECG), and fitness measurements were obtained before and after a 3-month endurance training program and compared with similar measurements obtained in nonexercising subjects. The supervised training program consisted of 50-minute jogging sessions 5 days a week at 85% of maximal heart rate. Compared with the control group, echocardiography after training showed an increase in left ventricular (LV) end-diastolic dimension (p less than 0.05). LV posterobasal wall thickness, septal wall thickness and ejection fraction did not change significantly. ECG measurements revealed a decrease in resting heart rate (p less than 0.05) and an increase in R-wave voltage in leads V5 and V6 (p less than 0.01). The measured maximal oxygen consumption increased by 16% (p less than 0.001). These data indicate that intense aerobic training in college-age men results in a significant increase in resting LV end-diastolic dimension and volume. The increase in maximal stroke volume associated with exercise training may be partially explained by these changes in cardiac dimensions.
Association of Dietary Intake of Soy, Beans, and Isoflavones With Risk of Cerebral and Myocardial Infarctions in Japanese Populations
Authors: Yoshihiro Kokubo, Hiroyasu Iso, Junko Ishihara, Katsutoshi Okada, Manami Inoue, Shoichiro Tsugane
Journal: Circulation (2007)

Background— Soy and isoflavones have been proposed to reduce the risk of cardiovascular risk factors, but their potential as preventatives for cardiovascular disease remains uncertain. We investigated the association of soy and isoflavone intake with risk of cerebral and myocardial infarctions (CI and MI). Methods and Results— To examine the association of soy and isoflavone intake with the risk of CI and MI, we studied 40 462 Japanese (40 to 59 years old, without cardiovascular disease or cancer at baseline). They completed a food-frequency questionnaire (1990–1992) and received follow-up to 2002. After 503 998 person-years of follow-up, we documented incidence of CI (n=587) and MI (n=308) and of mortality for CI and MI combined (n=232). For women, the multivariable hazard ratios and 95% confidence limits for soy intake ≥5 times per week versus 0 to 2 times per week were 0.64 (0.43 to 0.95) for risk of CI, 0.55 (0.26 to 1.09) for risk of MI, and 0.31 (0.13 to 0.74) for cardiovascular disease mortality. Similar but weaker inverse associations were observed between intake of miso soup and beans and risk of cardiovascular disease mortality. The multivariable hazard ratios for the highest versus the lowest quintiles of isoflavones in women were 0.35 (0.21 to 0.59) for CI, 0.37 (0.14 to 0.98) for MI, and 0.87 (0.29 to 2.52) for cardiovascular disease mortality. An inverse association between isoflavone intake and risk of CI and MI was observed primarily among postmenopausal women. No significant association of dietary intake of soy, miso soup, and beans and isoflavones with CI or MI was present in men. Conclusions— High isoflavone intake was associated with reduced risk of CI and MI in Japanese women. The risk reduction was pronounced for postmenopausal women.
CNS Effects or Mitral Commissurotomy
Authors: Murray E. Jarvik
Journal: JAMA (1964)

<h3>To the Editor:—</h3> I should like to second the letter of Klein and Pollack (<i>JAMA</i><b>188</b>:1017 [June 15] 1964) concerning the communication, "Psychological Deficits With Mitral Commissurotomy," by Herbert and Movius (<i>JAMA</i><b>187</b>:767 [March 7] 1964). The effects of practice are manifested almost universally when the same or similar psychological tests are repeated. The lack of a control group makes the results of the study clearly inconclusive. If the conclusions of the authors lead to complacency on the part of surgeons and anesthesiologists, incalculable harm could result with the use of cardiopulmonary bypass.
Blood Pressure Responses to the Valsalva Maneuver in Cardiac Patients with and without Congestive Failure
Authors: WALTER E. JUDSON, J. D. HATCHER, ROBERT W. WILKINS
Journal: Circulation (1955)

Compensated cardiac patients, like normal subjects, on performing the Valsalva maneuver show a decrease in systolic, diastolic, and pulse pressures during the blowing effort and a characteristic hypertensive overshoot after the release of the strain. Cardiac patients in congestive failure show the "failure response" with a maintenance of the systolic, diastolic, and pulse pressures during the expiratory strain and an absence of the overshoot afterwards. Experimental and clinical observations in patients indicate that this "failure response" is due to elevation of the right ventricular diastolic pressure, which interferes with the normal obstruction of venous return during the blowing effort of the Valsalva maneuver.
Intracoronary ultrasound imaging: Correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty
Authors: John McB. Hodgson, Karan G. Reddy, Randeep Suneja, Ravi N. Nair, Edward J. Lesnefsky, Helen M. Sheehan
Journal: Journal of the American College of Cardiology (1993)
Proton pump inhibitor use and risk of adverse cardiovascular events in aspirin treated patients with first time myocardial infarction: nationwide propensity score matched study
Authors: M. Charlot, E. L. Grove, P. R. Hansen, J. B. Olesen, O. Ahlehoff, C. Selmer, J. Lindhardsen, J. K. Madsen, L. Kober, C. Torp-Pedersen, G. H. Gislason
Journal: BMJ (2011)

<b>Objective</b> To examine the effect of proton pump inhibitors on adverse cardiovascular events in aspirin treated patients with first time myocardial infarction. <b>Design</b> Retrospective nationwide propensity score matched study based on administrative data. <b>Setting </b>All hospitals in Denmark. <b>Participants</b> All aspirin treated patients surviving 30 days after a first myocardial infarction from 1997 to 2006, with follow-up for one year. Patients treated with clopidogrel were excluded. <b>Main outcome measures</b> The risk of the combined end point of cardiovascular death, myocardial infarction, or stroke associated with use of proton pump inhibitors was analysed using Kaplan-Meier analysis, Cox proportional hazard models, and propensity score matched Cox proportional hazard models. <b>Results </b>3366 of 19 925 (16.9%) aspirin treated patients experienced recurrent myocardial infarction, stroke, or cardiovascular death. The hazard ratio for the combined end point in patients receiving proton pump inhibitors based on the time dependent Cox proportional hazard model was 1.46 (1.33 to 1.61; P&lt;0.001) and for the propensity score matched model based on 8318 patients it was 1.61 (1.45 to 1.79; P&lt;0.001). A sensitivity analysis showed no increase in risk related to use of H<sub>2</sub> receptor blockers (1.04, 0.79 to 1.38; P=0.78). <b>Conclusion </b>In aspirin treated patients with first time myocardial infarction, treatment with proton pump inhibitors was associated with an increased risk of adverse cardiovascular events.
The Reemerging HIV/AIDS Epidemic in Men Who Have Sex With Men
Authors: Harold W. Jaffe, Ronald O. Valdiserri, Kevin M. De Cock
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Monitoring Anesthetic Care: New Directions
Authors: Edward A. Brunner
Journal: JAMA (1989)

The article by Cheney et al<sup>1</sup>in this issue ofThe Journalrepresents a unique approach to the study of the outcome of medical care. A database of more than 1000 medical malpractice lawsuits related to anesthetic care was assembled from the closed claims files of 17 insurance companies willing to cooperate with the Committee on Professional Liability of the American Society of Anesthesiologists, under whose auspices the study was conducted. This is not the first time that the resource of malpractice closed claims has been used to evaluate the outcome of medical care. Caplan et al,<sup>2</sup>in a study of the first 900 closed insurance claims from the current database, identified 14 cases of sudden unexpected cardiac arrest during spinal anesthesia accompanied by heavy sedation. Previously, the National Association of Insurance Commissioners, in cooperation with member societies of the Council of Medical Specialty Societies, conducted an extensive
Wartime Activities of the Army Medical Department
Authors: Norman T Kirk
Journal: New England Journal of Medicine (1946)

IT IS a distinct privilege to be present at this annual meeting of the Tufts Medical Alumni Association. I look back with pleasant memories to about a year ago when I was present at the commissioning exercises of the graduating class of Tufts College Medical School and also those of Harvard and Boston universities. I thoroughly enjoyed renewing old acquaintances and making new friends on that occasion, and I am happy to be with you again tonight.I am aware of the great contribution that the Tufts Medical Alumni Association and the Tufts College Medical School have made in this . . .
European parliament agrees rules on cross border healthcare
Authors: R. Watson
Journal: BMJ (2011)

From 2013 people living in European Union countries will be able to receive reimbursable healthcare in another EU country, as long as the type of treatment and costs involved would normally be covered in their own national health jurisdiction.

The European parliament agreed the conditions for benefiting from this right in legislation adopted on 19 January. The new rules are designed to clarify the situation for patients and health services after a series of judgments by the European Court of Justice over the past decade opened the door to receiving medical care abroad.

Francoise Grossetete, the French MEP who steered the legislation through the parliament, said afterwards, “Patients …
Does house dust mite aggravate atopic eczema?
Authors: P.G. Norris, O. Schofield, R.D.R. Camp
Journal: British Journal of Dermatology (1987)

The significance of reports1,2, that topical application of house dust mite (HDM) to abraded or excoriated uninvolved skin of patients with atopic eczema can provoke an eczema‐like reaction is controversial. We have therefore studied 17 adult in‐patients with atopic eczema who demonstrated positive prick tests to Bencard HDM solution. One ml of Bencard HDM solution was applied, under a crepe bandage, daily for 5 days to an untreated 10 cm2 mildly eczematous area behind one knee, and diluent only, similarly, to the other knee in a double‐blind fashion. Test sites were assessed daily for itch using a visual analogue scale and for severity of erythema, papules and excoriation using a 3‐point grading system. Comparing these parameters between active and control sites for each patient, local worsening of eczema in response to HDM was marked in 5/17, moderate in 3/17 and mild in 4/17 subjects, while mild deterioration with diluent only occurred in 3/17. Mean area of active eczema increased by 6 26 ± 8 4 cm2 (± SD) at HDM‐treated and by 0 5 ±1.5 cm2 at control sites (P≤0.01; paired t‐test). Further patients exposed to Bencard horse hair extract, to which they were prick‐test negative, in place of HDM, showed no reaction. These results indicate that HDM can exacerbate pre‐existing atopic eczema.
Oral Treatment With α-Lipoic Acid Improves Symptomatic Diabetic Polyneuropathy
Authors: Dan Ziegler, Alexander Ametov, Alexey Barinov, Peter J. Dyck, Irina Gurieva, Phillip A. Low, Ullrich Munzel, Nikolai Yakhno, Itamar Raz, Maria Novosadova, Joachim Maus, Rustem Samigullin
Journal: Diabetes Care (2006)

OBJECTIVE—The aim of this trial was to evaluate the effects of α-lipoic acid (ALA) on positive sensory symptoms and neuropathic deficits in diabetic patients with distal symmetric polyneuropathy (DSP). RESEARCH DESIGN AND METHODS—In this multicenter, randomized, double-blind, placebo-controlled trial, 181 diabetic patients in Russia and Israel received once-daily oral doses of 600 mg (n = 45) (ALA600), 1,200 mg (n = 47) (ALA1200), and 1,800 mg (ALA1800) of ALA (n = 46) or placebo (n = 43) for 5 weeks after a 1-week placebo run-in period. The primary outcome measure was the change from baseline of the Total Symptom Score (TSS), including stabbing pain, burning pain, paresthesia, and asleep numbness of the feet. Secondary end points included individual symptoms of TSS, Neuropathy Symptoms and Change (NSC) score, Neuropathy Impairment Score (NIS), and patients’ global assessment of efficacy. RESULTS—Mean TSS did not differ significantly at baseline among the treatment groups and on average decreased by 4.9 points (51%) in ALA600, 4.5 (48%) in ALA1200, and 4.7 (52%) in ALA1800 compared with 2.9 points (32%) in the placebo group (all P &amp;lt; 0.05 vs. placebo). The corresponding response rates (≥50% reduction in TSS) were 62, 50, 56, and 26%, respectively. Significant improvements favoring all three ALA groups were also noted for stabbing and burning pain, the NSC score, and the patients’ global assessment of efficacy. The NIS was numerically reduced. Safety analysis showed a dose-dependent increase in nausea, vomiting, and vertigo. CONCLUSIONS—Oral treatment with ALA for 5 weeks improved neuropathic symptoms and deficits in patients with DSP. An oral dose of 600 mg once daily appears to provide the optimum risk-to-benefit ratio.
Treating depression in later life
Authors: Carolyn Chew-Graham, Robert Baldwin, Alistair Burns
Journal: BMJ (2004)

<h3>Abstract</h3> Mutant isocitrate-dehydrogenase-1 (IDH1-R132H; mIDH1) is a hallmark of adult gliomas. Lower grade mIDH1 gliomas are classified into two molecular subgroups: (i) 1p/19q co-deletion/TERT-promoter mutations or (ii) inactivating mutations in α-thalassemia/mental retardation syndrome X-linked (<i>ATRX</i>) and <i>TP53.</i> This work, relates to the gliomas' subtype harboring mIDH1, <i>TP53</i> and <i>ATRX</i> inactivation. IDH1-R132H is a gain-of-function mutation that converts α-ketoglutarate into 2-hydroxyglutarate (D-2HG). The role of D-2HG within the tumor microenvironment of mIDH1/mATRX/mTP53 gliomas remains unexplored. Inhibition of 2HG, when used as monotherapy or in combination with radiation and temozolomide (IR/TMZ), led to increased median survival (MS) of mIDH1 glioma bearing mice. Also, 2HG inhibition elicited anti-mIDH1 glioma immunological memory. In response to 2HG inhibition, PD-L1 expression levels on mIDH1-glioma cells increased to similar levels as observed in wild-type-IDH1 gliomas. Thus, we combined 2HG inhibition/IR/TMZ with anti-PDL1 immune checkpoint-blockade and observed complete tumor regression in 60% of mIDH1 glioma bearing mice. This combination strategy reduced T-cell exhaustion and favored the generation of memory CD8<sup>+</sup>T-cells. Our findings demonstrate that metabolic reprogramming elicits anti-mIDH1 glioma immunity, leading to increased MS and immunological memory. Our preclinical data supports the testing of IDH-R132H inhibitors in combination with IR/TMZ and anti-PDL1 as targeted therapy for mIDH1/mATRX/mTP53 glioma patients. <h3>Brief Summary</h3> Inhibition of 2-Hydroxyglutrate in mutant-IDH1 glioma in the genetic context of ATRX and TP53 inactivation elicits metabolic-reprograming and anti-glioma immunity.
A MODEL TO DESCRIBE THE PHARMACOKINETICS OF I-131 B72.3 MONOCLONAL ANTIBODY IN COLON CANCER PATIENTS
Authors: R Reilly, C DeAngelis, H Stern, J Kirsh, S Gallinger, M Papa, S Houle
Journal: Clinical Nuclear Medicine (1991)

S of the Society of Nuclear Medicine in Canada and Prairie Provinces Chapter, SNM Conjoint Meeting: PDF Only
Journal club summary page
Authors: Benjamin Prudon
Journal: Thorax (2013)

Completion of a full treatment programme for the management of tuberculosis is pivotal in achieving successful disease treatment and preventing development of drug resistant disease. In this study (Epidemiol Infect 2013;141:1223–1231), investigators compared characteristics of patients in the UK between 2001 and 2007 who completed TB therapy to those who were lost to follow-up. Factors associated with an increased risk of loss to follow-up included being male; adjusted odds ratio (aOR 1.29); having sputum smear-positive disease (aOR 1.25), and arriving in the UK within two years (aOR 3.58) particularly those of White ethnic origin (aOR 6.39).

This Europe-wide study (BMJ 2013;346:f2450 doi:10.1136/bmj.f2450) of patients presenting to primary care with acute cough investigated the additional benefit of adding either CRP or procalcitonin concentrations to clinical features for predicting the diagnosis of pneumonia. Data from 2820 patients were analysed, and 140 (5%) were identified as having pneumonia. The optimal combination of clinical prediction items included absence of rhinorrhoea and presence …
Acute Adenopathy in a Young Man
Authors: Leonard S. Gottlieb
Journal: JAMA (1973)

A26-year-old Portuguese man was brought to Boston City Hospital in a delirious and febrile state. He had painful inguinal swellings of twoweeks' duration. His history was obtained through interpreters. The patient had emigrated from his native Portugal to Angola six years prior to admission and had worked there as a farm laborer. Nine months ago, he entered the United States and has worked since as a machinist. The patient's health was excellent until two weeks prior to admission, when he reported to the emergency area of Boston City Hospital after the abrupt appearance of a tender mass in his right groin. Penicillin tablets were prescribed, and he was referred to the outpatient department for follow-up. He was seen there twice, once when he noted fever, chills, and the appearance of a similar mass in his left inguinal region, and again on the day of admission. On each occasion he was