tbuckley/cabot-search huggingface dataset:
The Diabetes Prevention Program and the Metabolic Syndrome
Authors: Trevor J. Orchard, Marinella Temprosa, Robert Ratner
Journal: Annals of Internal Medicine (2005)

Letters4 October 2005The Diabetes Prevention Program and the Metabolic SyndromeTrevor J. Orchard, MD, Marinella Temprosa, MS, and Robert Ratner, MDTrevor J. Orchard, MDFrom University of Pittsburgh, Pittsburgh, PA 15213; George Washington University, Rockville, MD 20852; and Medstar Research Institute, Hyattsville, MD 20783.Search for more papers by this author, Marinella Temprosa, MSFrom University of Pittsburgh, Pittsburgh, PA 15213; George Washington University, Rockville, MD 20852; and Medstar Research Institute, Hyattsville, MD 20783.Search for more papers by this author, and Robert Ratner, MDFrom University of Pittsburgh, Pittsburgh, PA 15213; George Washington University, Rockville, MD 20852; and Medstar Research Institute, Hyattsville, MD 20783.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-7-200510040-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank our correspondents for their interesting letters concerning sleep-related breathing disorder and fatty liver as related to the metabolic syndrome. In terms of sleep-related breathing disorder, we unfortunately have no specific data to provide but agree this is an interesting field for future study. We do, however, have data concerning liver enzymes. Although these were not provided in our most recent report because they do not form part of the National Cholesterol Education Program's definition of the metabolic syndrome, we consider this topic so relevant and important that a full, separate paper is in preparation to address ... Author, Article, and Disclosure InformationAffiliations: From University of Pittsburgh, Pittsburgh, PA 15213; George Washington University, Rockville, MD 20852; and Medstar Research Institute, Hyattsville, MD 20783.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized Trial Trevor J. Orchard , Marinella Temprosa , Ronald Goldberg , Steven Haffner , Robert Ratner , Santica Marcovina , Sarah Fowler , and The Diabetes Prevention Program and the Metabolic Syndrome Priscilla S. Sarinas and Daniel S. Dube The Diabetes Prevention Program and the Metabolic Syndrome Frank A. Anania , Samir Parekh , and Aasma Shaukat Metrics 4 October 2005Volume 143, Issue 7Page: 545-546KeywordsBreathingCholesterolConflicts of interestDiabetes preventionEnzymesFatty liverForecastingLiverMetabolic syndrome ePublished: 4 October 2005 Issue Published: 4 October 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
THE WAE AGAINST THE VENEREAL DISEASES IN FRANCE.
Authors: THEODORE TUFFIER
Journal: JAMA (1906)

The question of venereal prophylaxis is the order of the day in our country; from all sides medical men, statesmen and even literary men are combining their efforts to contend against this scourge. New measures are being studied and our<i>Société de Prophylaxie</i>, composed of internalists, surgeons, obstetricians, the most eminent members of the school of law and the principal police officials, meets once a month to consider important matters relative to the subject. This society has been productive of definite results. The system in use in France is composed of two separate branches—absolutely different—that is, the police and the medical service. Government surveillance is exercised in reference to houses of prostitution as well as to the so-called free prostitutes who are registered at police headquarters. The inmates of all houses are examined once a week, the others are obliged to report to the examiner once in two weeks. A
840-4 Failing fontan circulation necessitating transplantation: A clinicopathologic correlation
Authors: Fotios A Mitropoulos, Hillel Laks, Jacques Neelankavil, Juan Alejos, John S Child, Vivek Allada, Stacey Drant, Jon Kobashigawa, Jonah Odim, Michael Fishbein, Mark Plunkett
Journal: Journal of the American College of Cardiology (2004)
Parathyroid Hormone as a Trophic Hormone for 1,25-Dihydroxyvitamin D<sub>3</sub>, the Metabolically Active Form of Vitamin D
Authors: H. F. DeLuca
Journal: New England Journal of Medicine (1972)

Well known to the clinician is the fact that hypoparathyroid patients require large amounts of vitamin D or its close analogue, dihydrotachysterol, for the maintenance of reasonable plasma calcium concentrations. Not so well recognized is the fact that the presence of vitamin D or its metabolites is required for the parathyroid hormone to carry out its well known bone calcium mobilization function in the elevation of serum calcium concentration.1 Finally, hypoparathyroid patients who are resistant to massive amounts of vitamin D have been described.2 From these facts it seems clear that the bone function of both the parathyroid hormone and . . .
Patch testing with preservatives, antimicrobials and industrial biocides. Results from a multicentre study
Authors: None Schnuch, None Geier, None Uter, None Frosch
Journal: British Journal of Dermatology (1998)

Journal Article Patch testing with preservatives, antimicrobials and industrial biocides. Results from a multicentre study Get access A. Schnuch, A. Schnuch Information Network of Departments of Dermatology (IVDK)/Univ.‐Hautklinik, von Siebold Str. 3, D‐37075 Göttingen, Germany, Search for other works by this author on: Oxford Academic Google Scholar J. Geier, J. Geier Information Network of Departments of Dermatology (IVDK)/Univ.‐Hautklinik, von Siebold Str. 3, D‐37075 Göttingen, Germany, Search for other works by this author on: Oxford Academic Google Scholar W. Uter, W. Uter Department of Dermatology, University of Osnabrück, Germany, Search for other works by this author on: Oxford Academic Google Scholar P.J. Frosch P.J. Frosch Department of Dermatology, Dortmund/University of Witten‐Herdecke, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 138, Issue 3, 1 March 1998, Pages 467–476, https://doi.org/10.1046/j.1365-2133.1998.02126.x Published: 01 March 1998
Asymmetric Septal Hypertrophy (ASH) in Infancy
Authors: BARRY J. MARON, JESSE E. EDWARDS, WALTER L. HENRY, CHESTER E. CLARK, GLEEN J. BINGLE, STEPHEN E. EPSTEIN
Journal: Circulation (1974)

Clinical and pathologic observations were made in four infants who died with asymmetric septal hypertrophy in the first five months of life. One of these infants was stillborn and the other three were aged 1½ months, 4½ months, and 5 months at the time of their deaths. The three live-born infants demonstrated severe congestive heart failure and cardiac enlargement. The clinical features present in these three infants during life suggested a variety of other congenital cardiac malformations, including congenital mitral regurgitation, pulmonary stenosis, and endocardial fibroelastosis. In each of the four infants the ventricular septum was markedly hypertrophied and was thicker than the postero-basal left ventricular wall; septal to postero-basal free wall thickness ratios ranged from 1.8 to 2.6. Moreover, the septum of each infant contained a disordered arrangement of hypertrophied cardiac muscle cells. In three of the infants the myocardial cellular abnormalities were less marked in the left ventricular free walls than in the ventricular septum. In the fourth infant disorganized cardiac muscle cells were distributed widely in both the ventricular septum and left ventricular free wall; the clinical findings suggested the absence of left ventricular outflow obstruction in this infant. Asymmetric septal hypertrophy was documented in one first degree relative of each infant. It is concluded that asymmetric septal hypertrophy is a genetically transmitted disease that may present clinically in infancy and lead to infant death. Furthermore, the characteristic pathologic feature of asymmetric septal hypertrophy in adults, a disproportionately thickened ventricular septum containing numerous hypertrophied and disorganized cardiac muscle cells, can be present at birth.
The effect of PUVA treatment on acid hydrolases in human polymorphonuclear leukocytes
Authors: S. GRUNER, W. DIEZEL, A. ZWIRNER, G-M. MULLER, R. BAEHR, N. SONNICHSEN
Journal: British Journal of Dermatology (1987)

The activity of intracellular acid hydrolases in polymorphonuclear leukocytes (PMNL) from psoriatic patients and normal control subjects was determined. No significant differences between healthy and psoriatic individuals were detected, but a slight decrease in acid hydrolase activity was found in PMNL of psoriasis patients during PUVA therapy. PUVA treatment of PMNL in vitro at intensities that may be achieved in situ in the epidermis led to intracellular inactivation of acid hydrolases, which was not due to secretion of the enzymes or cell damage. The decrease in PMNL hydrolase activity appeared to be evoked by PUVA-generated reactive oxygen species because reduced glutathione prevented this decrease. The activity of free extracellular acid hydrolases was not affected by PUVA, and the superoxide production of PUVA-treated PMNL was increased. These results suggest that intracellular inactivation of acid hydrolases and possibly other lysosomal enzymes in PMNL or monocytes infiltrating the epidermis may contribute to the antipsoriatic activity of PUVA therapy.
CASE OF ARTIFICIAL ANUS IN THE LOIN
Authors: J. R. Humphreys
Journal: BMJ (1856)

nearly every plae in the Gulf, and was much interested in what I heard and saw.Probably, in the course of a fewyears, this part will be better known, should it become, as proposed, one of the routes to India.It may be mentioned, in con- clusion, that of the slaves brought into the Gulf from the shores of the Red Sea and Arabia, but one in ten survives, of those on whom the operation of castration is performed- a fact significant in more ways than one of the uncivilised state of these psas 4'the globe.4f CASE OF ARTIFICIAL AuS IN THE LOIN.By 3. R. HWMPHREYS, Esq., Slhrewsbury.ON September 11th, 1856, I was requested by Dr. Henry Johnson to see a patient of his, for the purpose of opening the colon in the loin, to relieve an obstruction of the bowels.Mrs. W., a thin haggard looking woman, aged 63, had not had a motion of her bowels for the last ten days.She complained of constant and most distressing pain of the belly, which was tympauitic; and the distended colon was plainly seen throughout most of its course.There was a
Doctors to face disciplinary action over Irish hepatitis C scandal
Authors: D. Payne
Journal: BMJ (1998)

The Irish Medical Council's fitness to practice committee is to begin a disciplinary examination of the role of several doctors criticised by an official Tribunal of Inquiry into the country's hepatitis C scandal. More than 1000 mothers were infected through contaminated anti-D immunoglobulin in the mid-1970s.

The tribunal, which reported last March, put responsibility for the contamination squarely on the senior medical staff of the Blood Transfusion Service Board. The tribunal specifically named …
Efficacy and safety of tabalumab, an anti-B-cell-activating factor monoclonal antibody, in patients with rheumatoid arthritis who had an inadequate response to methotrexate therapy: results from a phase III multicentre, randomised, double-blind study
Authors: Josef S Smolen, Michael E Weinblatt, Désirée van der Heijde, William F C Rigby, Ronald van Vollenhoven, Clifton O Bingham, Melissa Veenhuizen, Anne Gill, Fangyi Zhao, Wendy J Komocsar, Pierre-Yves Berclaz, Robert Ortmann, Chin Lee
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> Randomised, double-blind, placebo-controlled study to evaluate efficacy and safety of tabalumab in patients with rheumatoid arthritis (RA) with inadequate responses to methotrexate (MTX-IR). <h3>Methods</h3> 1041 patients with moderate–severe RA despite ongoing MTX enrolled in a 52-week study evaluating subcutaneous tabalumab 120 mg every four weeks (120/Q4W) or 90 mg every two weeks (90/Q2W) versus placebo. Primary endpoints were American College of Rheumatology 20% (ACR20) response rate and Health Assessment Questionnaire-Disability Index change from baseline at 24 weeks and modified Total Sharp Score (mTSS) change at 52 weeks. <h3>Results</h3> There were no significant differences in ACR20 responses at week 24 or mTSS change from baseline at week 52 among treatment groups. Declines were seen in CD20+ B cells and immunoglobulin levels in tabalumab groups, but not placebo: B cells (−15.0%, −18.8%, 5.3%, in the 120/Q4W, 90/Q2W, and placebo groups, respectively); IgM (−16.3%, −19.4%, −0.1%), IgA (−11.4%, −4.7%, 1.2%) and IgG (−8.6%, −7.8%, 0.1%). Discontinuations due to adverse events were similar between groups. Numerically more serious infections were reported in tabalumab groups (1.7%, 0.6%, 0.3%); numerically more injection-site reactions were reported in the 90/Q2W group (2.3%, 4.3%, 2.3%). <h3>Conclusions</h3> Neither clinical efficacy nor significant safety signals were observed with tabalumab despite evidence of biological activity. This study was terminated early due to insufficient efficacy. <h3>Trial registration number</h3> NCT01198002.
Neuro-Ophthalmology: Diagnosis and Management
Authors: Walter M. Jay
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prostate Cancer in a Transgender Woman 41 Years After Initiation of Feminization
Authors: Rebecca A. Miksad, Glenn Bubley, Paul Church, Martin Sanda, Neil Rofsky, Irving Kaplan, Amiel Cooper
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tetrahydroaminoacridine and Phencyclidine Intoxication
Authors: Maurice S. Albin
Journal: JAMA (1978)

<h3>To the Editor.—</h3> During the past year the press and television have reported an alarming increase in drug abuse due to the intake of phencyclidine (PCP, "angel hair," "peace pill") because of its relatively easy manufacture and availability. The symptoms from phencyclidine intoxication can consist of excessive vocalization (including screaming, crying, and irrational speech), severe excitation, delirium, hallucinations, and paranoia. We have found that intravenous tetrahydroaminoacridine hydrochloride (THA) is effective in attenuating many of these responses in the animal model.<sup>1,2</sup>Unfortunately, the National Institute of Drug Abuse has not found our grant applications meritorious enough to merit funding, and we have not been able to continue with our investigative efforts. In light of the spread of phencyclidine use in the drug scene, we believe it is important to mention to interested physicians that THA can be obtained for human use under an Investigational New Drug Application as prescribed by
John Patrick Acton Weaver
Authors: R. H. MacDougall
Journal: BMJ (2011)

John Patrick Acton Weaver came to Scotland to join Professor Sir Donald Douglas’ surgical academic team in the University of St Andrews at Dundee in 1967. He gave outstanding service to that flourishing surgical unit, to the university, and to the health service. This was particularly so when the surgical unit moved to the new Ninewells Hospital and Medical School, and during the period when Sir Donald Douglas was president of the Royal College of Surgeons of Edinburgh. Patrick ran the unit. His surgical interests evolved into urology, and he subsequently became NHS consultant urological surgeon in 1976, …
New Views on the Psychodynamics of Schizophrenia
Authors: SILVANO ARIETI
Journal: American Journal of Psychiatry (1967)

Although he reaffirms the importance of early life experiences in the development of schizophrenia, the author emphasizes the essential role played by later experiences involving what Freud called the secondary process. Preschizophrenic panic occurs when the archaic infantile thought process and its original content are reactivated by later conceptual conclusions, with a resulting unacceptable image of the self. The psychosis then becomes a defense against the terrifying and injurious self-image.
High Rate of Mutations in the Hepatitis B Core Gene During the Immune Clearance Phase of Chronic Hepatitis B Virus Infection
Authors: H Bozkaya, B Ayola, A S F Lok
Journal: Hepatology (1996)

Cross–sectional studies reported that hepatitis B core gene mutations are associated with active liver disease and responsiveness to interferon therapy. In view of the heterogeneity in published sequences, it is not possible to tell whether the differences in sequences observed were true mutations that developed during the course of infection. We conducted a longitudinal study to determine the rate of hepatitis B core gene mutations and the timing of these mutations in relation to hepatitis B virus replication, activity of liver disease, hepatitis B virus replication, activity of liver disease, hepatitis B e antigen (HBeAg) seroconversion, and interferon therapy. Serial sera from 55 patients with chronic hepatitis B infection were analyzed by direct sequencing of the hepatitis B precore/core gene to identify the nucleotide and amino acid changes that emerged during during follow–up. Patients who remained HBeAg positive and had normal amino transferase levels (Group I) maintained higher serum hepatitis B virus (HBV) DNA levels but significantly lower rates of both nucleotide and amino acid changes during follow–up compared with patients who remained HBeAg positive but had elevated aminotransferase levels (Groups II) and patients who cleard HBeAg (Group III). The rates of nucleotide and amino acid changes in Groups I, II, III patients were: 0.4 +/– 0.1, 1.9 +/– 0.3, and 2.4 +/– 0.4/nucleotide position/year; and 0.04 +/– 0.02, 0.21 +/– 0.05, and 0.38 +/– 0.07/codon/year, respectively. Most of the amino acid changes in Groups II and III patients occured during or shortly after flares in amino transferase levels, before HBeAg seroconversion. Similar rates of nucleotide and amino acid changes were found in interferon treated versus untreated patients, and in responders versus nonresponders. There was no difference in the location or nature of the hepatitis B core gene mutations between patients with and without HBeAg seroconversion, interferon treated versus untreated patients, and interferon responders versus nonresponders. In summary, changes in the hepatitis B core gene sequence was rarely detected in patients who were still in the immune tolerant phase but very high rates of changes were found during the immune clearance of chronic hepatitis B infection. Interferon therapy did not induce a higher rate or specific pattern of mutations in the hepatitis B core gene. Response to interferon therapy in HBeAg positive patients was unrelated to the number or location of hepatitis B core gene mutations.
Editors and advertisements. What responsibility do editors have for the advertisements in their journals?
Authors: D. Rennie
Journal: JAMA (1991)

Drug advertisements figure heavily in clinical journals. Indeed, the inclusion of ads directed toward the prescribing physician practically defines the journals as being clinical. Such ads merit particular scrutiny because the person they try to reach, the physician, is not the one who has to pay for the product. Goldstein,<sup>1</sup>in a witty and perceptive Commentary, questions whether the judgment of editors of clinical journals is affected by the fact that their journals are supported in part by money paid to them by pharmaceutical companies to publish ads for drugs. He draws a parallel between the editors' acceptance of ads and physicians' accepting gifts from drug company representatives. Indeed, he gives a partial, but impressively long, list of the freebies he has himself received: not, perhaps, the best stance from which to question the practices of others, but disarmingly honest. Having concluded that there is a problem with journals,
Painful Swelling of the Finger
Authors: Frederick A. J. Kingery
Journal: JAMA (1964)

A 22-YEAR-OLD pediatric nurse suddenly developed severe pain and swelling of the distal portion of the right index finger (Fig 1). This appeared to have its origin at the site of a superficial abrasion acquired four days before while cleaning some instruments in a pediatric nursery. Multiple deep vesicles and pustules rapidly appeared on a broad erythematous base. The most striking feature was the pain, which required narcotics for relief. Regional axillary nodes were enlarged and tender. Her temperature was 100.6 F (38.1 C). The white blood cell count was diminished to 2,300 cells per cubic millimeter with a normal differential. A smear of the cells at the base of a vesicle (Tzanck Test) shows intranuclear inclusion bodies (Fig 2). Bacterial and fungal cultures were negative. The finding of inclusion bodies on the Tzanck smear establishes the viral etiology of the lesion. Further questioning uncovers the fact that some of
Tumour of Both Frontal Lobes
Authors: J. Russell
Journal: BMJ (1881)

THE BRITISH MEDICAL 7OURNAL inferior vena cava to the heart, and how almost immediately underneath the right auricle we have the fibrous opening in the diaphragm for the passage of this vessel, there seems good reason for the opinion, so generally entertained, of the great danger of a complete dislocation of the heart to the right side; the inferior vena cava must be verY seriously interfered with, and hence the dread of sudden death in tZese cases seems only reasonable.In my opinion, however, the great danger of this condition rests on the rapidity of the dislocation; for, if the effusion only increase very gradually, the heart, like every other organ in the