tbuckley/cabot-search huggingface dataset:
Incident &lt;EMPH TYPE="ITAL"&gt;Chlamydia trachomatis&lt;/EMPH&gt; Infections Among Inner-city Adolescent Females
Authors: G R Burstein, C A Gaydos, M Diener-West, M R Howell, J M Zenilman, T C Quinn
Journal: JAMA (1998)

Context.-Adolescents are at highest risk for infection with Chlamydia trachomatis, an important preventable cause of pelvic inflammatory disease and subse- quent tubal factor infertility in US women.Current guidelines for delivery of adolescent primary care services recommend yearly chlamydia screening for those adolescent females considered to be at risk.Objectives.-To describe the epidemiology of prevalent and incident chlamydia infection among adolescent females to assess the appropriate interval for chlamydia screening and to define risk factors that would identify adolescent females to target for screening.Design.-Prospective longitudinal study.Patients.-Aconsecutive sample of 3202 sexually active females 12 through 19 years old making 5360 patient visits over a 33-month period, January 1994 through September 1996.Setting.-Baltimore, Md, family planning, sexually transmitted disease, and school-based clinics.Intervention.-Testing for C trachomatis by polymerase chain reaction.Main Outcome Measures.-Prevalenceand incidence of C trachomatis infections; predictors of positive test result for C trachomatis.Results.-Chlamydia infection was found in 771 first visits (24.1%) and 299 repeat visits (13.9%); 933 adolescent females (29.1%) had at least 1 positive test result.Females who were 14 years old had the highest age-specific chlamydia prevalence rate (63 [27.5%] of 229 cases; P=.01).The chlamydia incidence rate was 28.0 cases per 1000 person-months (95% confidence interval, 24.9-31.5 cases).The median time was 7.2 months to a first positive chlamydia test result and 6.3 months to a repeat positive test result among those with repeat visits.Independent predictors of chlamydia infection-reason for clinic visit, clinic type, prior sexually transmitted diseases, multiple or new partners, or inconsistent condom use-failed to identify a subset of adolescent females with the majority of infections.Conclusions.-Ahigh prevalence and incidence of C trachomatis infection were found among adolescent females.We, therefore, recommend screening all sexually active adolescent females for chlamydia infection every 6 months, regardless of symptoms, prior infections, condom use, or multiple partner risks.
Temporal Trends, Practice Patterns, and Treatment Outcomes for Infected Upper Urinary Tract Stones in the United States
Authors: Jesse D. Sammon, Khurshid R. Ghani, Pierre I. Karakiewicz, Naeem Bhojani, Praful Ravi, Maxine Sun, Shyam Sukumar, Vincent Q. Trinh, Keith J. Kowalczyk, Simon P. Kim, James O. Peabody, Mani Menon, Quoc-Dien Trinh
Journal: European Urology (2012)
Paradigm, parameter, paralysis of mind.
Authors: N W Goodman
Journal: BMJ (1993)

Mission statement."A shining beacon, guiding every action " Promote positive health: ostentatiously do something that is good for you, like going jogging or eating brown bread?Can you promote negative health?Purchasing intelligence: a contradiction in terms.Resettlement plans: move clients/residents/patients out of the institutions where they have lived for years and that they probably regard as their homes.Seamless care: care will be seamless when LAs do everything that HAs think they should.And vice versa.Until then, the holes in the seams will still need patching up.Share: tell; pass the problem on to someone else."I would like to share this with you" never means their last Rolo.Smooth take off: no discernible change.Targeted briefs: Y fronts.Tight deadline: 12 noon today, or yesterday.Top down, bottom up (not a strip wash in a youth hostel): involving the whole organisation.Trolley wait: it's not the trolley we're concerned about, but the patient on
Physician Payment: Fee for Time
Authors: John H. Lossing
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Reimbursement for physician services based on time is not a good idea. Like Medicare and Medicaid it would assist physicians in cheating, and eventually patients would have to pay with their time and diminished access to physicians. Despite assertions to the contrary, it is impossible to guess how long a new or return appointment will take. Some patients require, and some demand, more time. A physician would lose 25 minutes for each patient who only consumes 5 minutes of a scheduled 30-minute return visit. If a physician schedules all patients for 5 minutes, he or she could be running 4 hours late at the end of the day. The only fair way to handle this will be to stop scheduling any appointments at all and handle all patients on a walk-in basis, like a barber shop. Since Medicare precludes side contracts with patients, even millionaire attorneys would
Abstract 797: Kinase activity profiling of tumor tissues of different origin
Authors: Rob Ruijtenbeek, Liesbeth Houkes, Arzu Umar, Jeannette Oosterwijk-Wakka, Rik de Wijn, Victor Thijssen, John Martens, Anne-Marie Dingemans, Egbert Oosterwijk, Riet Hilhorst
Journal: Cancer Research (2010)

Abstract Introduction: Many new anti-cancer drugs target kinase activity. Unfortunately, methods to monitor the drug effects at the enzymatic level in patient derived tumor tissue are lacking. Here, a novel molecular profiling method for application in biomarker discovery is presented. This method is based on measuring kinase activities in tumor tissue extracts, and involves assessment of inhibition by a drug of interest. This ex vivo activity-based approach is enabled by dynamic peptide microarrays. These arrays comprise of peptides, which are known substrates for phosphorylation by protein kinases. Here we investigated the applicability of this approach in the classification of multiple tumors of different origin. Method: Patient-derived fresh frozen tissues of different tumor types (24 breast cancer (BC), 14 non-small cell lung cancer (NSCLC), 12 renal cell carcinomas (RCC)) were used for extraction of total protein in lysis buffer. Dependent on the tissue source, 6 slices of 10 µm were sufficient for 20-100 microarray analyses. Equal amounts of total protein were analyzed for kinase activity on dynamic PamChip peptide microarrays. These arrays comprised 144 or 256 different peptides. A PamChip96 plate format was used, enabling 96 microarray incubations per run. Protein amounts ranging from 1 − 5 µg were used per microarray analysis. Tumor extracts were analysed in the presence and absence of kinase inhibitor drugs (RCC: sorafenib and sunitinib, NSCLC: gefitinib). Results: We show here that from different tumors kinase activity profiles could be generated reproducibly (10-15% CV for selected peptides). Control experiments showed protein concentration and ATP dependency. In the RCC experiments different phosphorylation profiles were obtained when the non-tumor tissue was compared to tumor tissue derived from the same patient, showing higher kinase activities in the latter. In addition, inhibitor dependent modulation of the peptide phosphorylations was observed (sorafenib vs. sunitinib). Furthermore, differential kinase activity profiles were obtained that could be correlated to different patient subgroups (BC) or clinical data (long vs. short term survivors; NSCLC). Conclusion: A novel molecular profiling approach was successfully applied for classification of different tumors. This approach is based on detection of kinase activities as well as inhibition of kinase activity in tumor tissues. Application of this method in the discovery of biomarkers for diagnosis, prognosis or prediction of drug response is foreseen. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 797.
NOTE ON A LITTLE-KNOWN BOOK ON THE SKIN.
Authors: GEORGE PERNET
Journal: British Journal of Dermatology (1926)

Journal Article NOTE ON A LITTLE‐KNOWN BOOK ON THE SKIN. Get access GEORGE PERNET, M.D. GEORGE PERNET, M.D. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 38, Issue 1, 1 January 1926, Pages 27–28, https://doi.org/10.1111/j.1365-2133.1926.tb13156.x Published: 01 January 1926
Unusual Patterns of I-131 Accumulation
Authors: M Ozguven, Seyfettin Ilgan, A Ozgur Karacalioglu, Nuri Arslan, Emel Ozturk
Journal: Clinical Nuclear Medicine (2004)

Nonphysiologic I-131 uptake detected on images is usually interpreted as suggesting functioning thyroid metastases. However, extrathyroidal I-131 accumulation does not always imply thyroid cancer metastases and has been reported on many occasions, including various nonthyroidal neoplasms and contamination by body secretions. To avoid unnecessary therapeutic interventions, it is extremely important to distinguish properly false-positive sites of I-131 localization. The authors report 2 examples of unusual false-positive I-131 whole-body scans in papillary thyroid carcinoma caused by chronic sialadenitis of a submandibular gland and a maxillary mucous retention cyst. False-positive uptake and contamination sources were elucidated by careful examination of the patients and further imaging studies
Acute hemodynamic effects of biventricular DDD pacing in patients with end-stage heart failure
Authors: Christophe Leclercq, Serge Cazeau, Hervé Le Breton, Philippe Ritter, Philippe Mabo, Daniel Gras, Dominique Pavin, Arnaud Lazarus, Jean-Claude Daubert
Journal: Journal of the American College of Cardiology (1998)
Methylenetetrahydrofolate Reductase Gene Polymorphisms: Genomic Predictors of Clinical Response to Fluoropyrimidine-Based Chemotherapy in Females
Authors: Laia Paré, Juliana Salazar, Elisabeth del Rio, Montserrat Baiget, Albert Altés, Eugenio Marcuello, David Paez, Agustí Barnadas
Journal: Journal of Clinical Oncology (2008)

The article by Zhang et al 1 provides evidence that A1298C polymorphism in methylenetetrahydrofolate reductase (MTHFR) has a role as a prognostic marker in female patients with metastatic colon cancer treated with fluorouracil (FU) -based chemotherapy.The authors stated that further studies are needed to confirm these findings.Recently, we reported a study in 94 patients with metastatic colorectal cancer who received FU and oxaliplatin chemotherapy as first-line treatment. 2The aim of the study was to ascertain whether polymorphisms 677 C Ͼ T and 1298 A Ͼ C in the MTHFR gene could be used as genomic predictors of clinical outcome in this group of patients.Our results showed a lack of predictive value of these two MTHFR polymorphisms in this cohort.As we did not perform a stratified analysis by sex in our study, Zhang et al's results 1 prompted us to replicate their sex-specific analysis in our series of patients.We analyzed the previously studied population enlarged with 93 additional patients who met the inclusion and exclusion criteria defined in our previous study.Our present cohort comprised a total of 187 patients, 67 women (36%) and 120 men (64%).There were no statistically significant differences between the two populations-males and females-regarding location of the primary tumor, number of metastatic sites, WBC at diagnosis, Eastern Cooperative Oncology Group performance status, phosphatase alkaline levels, or global clinical assessment risk according to Kohne et al's classification. 3Age was significantly different in the two groups (median age, 62 years for women and 67 years for men; P ϭ .004).The MTHFR polymorphisms were tested as previously described. 2For MTHFR C677T polymorphism, 38% of patients had the C/C genotype (71 of 187 patients), 51% of patients had the C/T genotype (95 of 187 patients), and 11% of patients had the T/T genotype (21 of 187 patients).For MTHFR A1298C polymorphism, 46.5% of patients had the A/A genotype (87 of 187), 46.5% had the A/C genotype (87 of 187), and 7% had the homozygous C/C genotype (13 of 187 patients).We found no differences in overall survival (OS) related to the MTHFR C677T or MTHFR A1298C markers when the analysis was performed without taking into account the variable sex.When the statistical analysis was stratified by sex, we found no differences in OS in men or women groups according to the MTHFR C677T polymorphism.However, when the patient population was separated by sex,
Early Discharge of Newborns-Reply
Authors: Lenna L. Liu, David K. Shay, Robert L. Davis, Alvin H. Novack, Conrad J. Clemens
Journal: JAMA (1997)

In Reply  —Drs Cass and Volk suggest that an NNT analysis is a necessary adjunct to the interpretation of our study. While we agree that this provides valuable information to physicians, health care organizations, and policymakers, interpretation of NNT results will also vary depending on one's viewpoint (patient, provider, or payer) and the outcome in question. With regard to inclusion of the  discharge group, we elected not to include this group because their LOS overlapped with both early- and late-discharge groups. Given this misclassification, an estimate of the effect of intermediate discharge would be misleading. Cass and Volk are correct in pointing out the increased risk among newborns discharged the day following birth but within 24 hours. We believe that this highlights the importance of careful evaluation of newborns born late in the day who are discharged early the next morning. Furthermore, it illustrates the necessity of expanding the definition of
Mass vaccination programme aimed at eradicating measles, mumps, and rubella in Sweden: first experience.
Authors: B Christenson, M Bottiger, L Heller
Journal: BMJ (1983)

General vaccination with a combined measles, mumps, and rubella vaccine was introduced in Sweden in 1982. The immunisation schedule comprises two vaccine injections, given at 18 months and 12 years of age, respectively. A controlled field study was carried out in 150 children aged 18 months using two different batches of the vaccine. Seroconversion was seen in 96% against measles, 93% against mumps, and 99% against rubella--the same rates with both vaccine lots. Nevertheless, a difference was noted between the two batches with respect to postvaccination reactions. Fever and rash were recorded mainly five to 12 days after vaccination. Moderate fever (38.5-39.4 degrees C) was observed in 22 children, high fever (greater than or equal to 39.5 degrees C) in 33, and rash in 35. Preliminary results obtained by follow up of routinely vaccinated schoolchildren aged 12 indicated considerably lower rates of fever and rash during the postvaccination period, occurring in 3-10% of cases only. These findings show that complete eradication of measles, mumps, and rubella in Sweden is entirely practicable by the mass vaccination programme and that side effects of vaccination are likely to be few and mild.
Acute Effects of High-Fat Meals Enriched With Walnuts or Olive Oil on Postprandial Endothelial Function
Authors: Berenice Cortés, Isabel Núñez, Montserrat Cofán, Rosa Gilabert, Ana Pérez-Heras, Elena Casals, Ramón Deulofeu, Emilio Ros
Journal: Journal of the American College of Cardiology (2006)
Erythropoietin regulates endothelial progenitor cells
Authors: Ferdinand H. Bahlmann, Kirsten de Groot, Jens-Michael Spandau, Aimee L. Landry, Barbara Hertel, Thorsten Duckert, Sascha M. Boehm, Jan Menne, Hermann Haller, Danilo Fliser
Journal: Blood (2003)
Biomarkers for Detecting and Risk-Stratifying Chronic Kidney Disease—Reply
Authors: Carmen A. Peralta, Michael G. Shlipak
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE VESICULAR MURMUR AND ITS RELATION TO PULMONARY HEALTH AND DISEASE.
Authors: THOMAS NEIL McLEAN
Journal: JAMA (1901)

My purpose in this writing is to individualize this one and only ausculatory sign as the criterion of pulmonary health, its absence as the positive proof of either functional or organic disease, also suggestions as to the most successful method of restoration and its application to the treatment of pulmonary tuberculosis. In the auscultation of the normally acting healthy chest, two sounds are heard on inspiration, totally different in production, location and character. The first is the bronchial sound, caused by the friction of the inrushing tidal air, through the convective system of tubes, and is, in varying quality and pitch, always present in health and disease. It is first in regard to the time of its production in the inspiratory act, and, during the first eight to twelve years of life, is the only sound heard in health, the pulmonary system being as yet incomplete. The tidal air does
Radiology in Disorders of the Liver, Biliary Tract and Pancreas: With Special Reference to the Use of Angiography in the Diagnosis of Resectable Tumors
Authors: Constantin Cope
Journal: JAMA (1982)

This beautiful radiological atlas illustrates modern diagnostic concepts that are used in the evaluation of hepatobiliary and pancreatic diseases. Tumor screening, done by scintigraphy, ultrasound, and computed tomography, is followed by a combination of percutaneous transhepatic cholangiography (PTC), endoscopic retrograde cholangiopancreatography (ERCP), and high-quality visceral angiography for more definitive diagnosis and staging. From his extensive experience with pancreatic biliary disease, Dr Ariyama reports an unusually high degree of success (over 90%) with retrograde cannulation of the bile duct and the pancreatic duct, all without morbidity, a remarkable feat of technical wizardry. Unfortunately, clinical and technical details are not described in the text, but most can be found from the bibliography. Useful diagnostic information is given in the presentation of large series of hepatomas and biliary tract malignancies. Ariyama has made an important contribution in the early diagnosis of pancreatic carcinoma by championing the free and early use of ERCP and
Successful Immunosuppressive Treatment of High-Titer Postpartum Factor VIII Inhibitor
Authors: Joyce M. Annichino-Bizzacchi
Journal: Annals of Internal Medicine (1993)

Letters1 December 1993Successful Immunosuppressive Treatment of High-Titer Postpartum Factor VIII InhibitorJoyce M. Annichino-Bizzacchi, MD, Tanya F. G. S. Machado, MD, and Valder R. Arruda, MDJoyce M. Annichino-Bizzacchi, MDSearch for more papers by this author, Tanya F. G. S. Machado, MDSearch for more papers by this author, and Valder R. Arruda, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-11-199312010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In a recent report, Lian and colleagues [1] described the effectiveness of combined cyclophosphamide, vincristine, and prednisone (CVP) therapy after antigenic stimulation with factor VIII to eradicate factor VIII inhibitor. We report the use of this regimen in a nonhemophilic woman with high-titer postpartum antibody against factor VIII that was resistant to other treatments.A 45-year-old nonhemophilic black woman was first seen at the hospital in September 1990. She had a 10-year history of recurrent postpartum bleeding, characterized by epistaxis, ecchymoses, hematomas, and post-traumatic or spontaneous hemarthrosis. No history of previous bleeding or familial history of bleeding ...References1. Lian EC, Larcada AF, Chiu AY. Combination immunosuppressive therapy after factor VIII infusion for acquired factor VIII inhibitor. Ann Intern Med. 1989; 110:774-8. Google Scholar2. Green D, Lechner K. A survey of 215 non-hemophilic patients with inhibitors to factor VIII. Throm Haemost. 1981; 45:200-3. Google Scholar3. Michiels JJ, Bosh LJ, van der Plas PM, Abels J. Factor VIII inhibitor postpartum. Scand J Haematol. 1978; 20:97-107. Google Scholar4. Herbst KD, Rapaport SI, Kenoyer DG, Stanton W, Feinstein DI. Syndrome of an acquired inhibitor od factor VIII responsive to cyclophosphamide and prednisone. Ann Intern Med. 1981; 95:575-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClotting Disorders 1 December 1993Volume 119, Issue 11Page: 1149-1150KeywordsAntigensCyclophosphamideHemarthrosisHemorrhageImmunosuppressivesPregnancy ePublished: 15 August 2000 Issue Published: 1 December 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Road traffic and respiratory health of children.
Authors: K Perrett
Journal: BMJ (1993)

ED1TOR,-MY editorial on retinopathy of pre- maturity mentioned antioxidants in general, both regarding aetiology and prevention.Several anti- oxidant mechanisms have certainly been described previously,' but owing to restriction of space vitamin E was the only antioxidant specifically mentioned in the editorial.I agree that trans- ferrin also is very interesting.Further research concerning the relation of iron and transferrin concentrations in extremely premature children and development of retinopathy of prematurity, as well as the possible preventive effects of transferrin on retinopathy ofprematurity, will be welcomed.