tbuckley/cabot-search huggingface dataset:
Deaths from asthma.
Authors: K. N. Palmer, M. L. Diament
Journal: BMJ (1968)

asthmatic patient's restlessness and irrational behaviour is due to his anoxaemia and hypercarbia and can be safely relieved only by adequate ventilation.So far as the actual management of status asthmaticus is concerned, I am again highly surprised to see so many experts putting such great accent on the use of corticosteroids without mention of the fundamental approach of hydration of the patient in status asthmaticus.This is im- perative if we are to encourage the thinning out and eventual expectoration of the dried- up secretions and mucous plugs.Undetected respiratory infections have been reported as one of the causes of death in bronchial asthma, and a high index of suspicion with prompt and adequate institution of an appropriate antibiotic therapy could save many lives.Finally, close follow-up of the clinical pic- ture as well as frequent evaluation of the level of blood gases and the availability of a team of trained personnel for possible assisted respiration is invaluable if we are to do all in our power to save these patients.-Iam, etc.,
Effect of the <i> <scp>FTO</scp> </i> rs9930506 polymorphism on obesity and the main clinical outcomes in patients with psoriasis
Authors: P. Coto‐Segura, L. González‐Lara, N. Eiris, J. Santos‐Juanes, R. Queiro, E. Coto
Journal: British Journal of Dermatology (2014)

Funding sources: this work was supported by a grant from the Spanish Instituto de Salud Carlos III–European FEDER funds (grant PI 13/00680). Conflicts of interest: none declared. Dear Editor, It is a well‐established fact that psoriasis is associated with comorbidities such as obesity, diabetes mellitus and metabolic syndrome.1 2 3 A recent meta‐analysis showed a higher frequency of obesity among patients with psoriasis compared with controls, and patients with severe psoriasis have a greater risk for obesity than those with mild psoriasis.4 The fat mass and obesity‐associated gene (FTO) has been associated with body mass index (BMI) and obesity in different populations.5 6 7 A linkage disequilibrium block defined by single nucleotide polymorphisms (SNPs), such as rs9930506 in intron 1, showed the strongest association with BMI. FTO is a nucleic acid demethylase ubiquitously expressed, with the highest levels seen in the brain hypothalamic nuclei, a region that regulates energy homeost‐asis. We hypothesized that the rs9930506 SNP could be also linked to differences in BMI and other metabolic traits among patients with psoriasis. In addition, we sought to determine whether this FTO polymorphism was a genetic determinant of the risk for arthritis and disease severity in our patients.
CD14-Deficient Mice Are Protected Against Lipopolysaccharide-Induced Cardiac Inflammation and Left Ventricular Dysfunction
Authors: Pascal Knuefermann, Shintaro Nemoto, Arunima Misra, Naoki Nozaki, Gilberto Defreitas, Sanna M. Goyert, Blase A. Carabello, Douglas L. Mann, Jesus G. Vallejo
Journal: Circulation (2002)

Background— The molecular mechanisms responsible for sepsis-induced myocardial dysfunction remain undefined. CD14 mediates the inflammatory response to lipopolysaccharide (LPS) in various organs including the heart. In this study we investigated the role of CD14 in LPS-induced myocardial dysfunction in vivo. Methods and Results— Wild-type and CD14-deficient (CD14-D) mice were challenged with Escherichia coli LPS. Myocardial tumor necrosis factor, interleukin-1β (IL-1β), and NOS2 induction was measured before and 6 hours after LPS challenge. Echocardiographic parameters of left ventricular function were measured before and 6 hours after LPS administration. LPS challenge induced a significant increase in myocardial tumor necrosis factor and IL-1β mRNA and protein expression in wild-type mice. In contrast, mRNA and protein levels for TNF and IL-1β were significantly blunted in CD14-D mice. An increase in NOS2 protein was noted within 6 hours of LPS provocation only in the hearts of wild-type mice. This was associated with an increase in ventricular cGMP levels. Activation of nuclear factor-κB was observed within 30 minutes of LPS in the hearts of wild-type mice but not in CD14-D mice. In wild-type mice, LPS significantly decreased left ventricular fractional shortening, velocity of circumferential shortening, and dP/dt max . LPS-treated CD14-D mice maintained normal cardiac function. Conclusions— These results suggest that CD14 is important in mediating the proinflammatory response induced by LPS in the heart and that CD14 is necessary for the development of left ventricular dysfunction during LPS-induced shock in vivo.
Potassium transport by the isolated perfused kidney.
Authors: P Silva, B D Ross, A N Charney, A Besarab, F H Epstein
Journal: Journal of Clinical Investigation (1975)

Rat kidneys perfused outside of the body with an artificial medium are able to increase their fractional excretion of potassium in response to a rising concentration of potassium in the medium but never show net secretion of potassium. By contrast, isolated perfused kidneys from chronically potassium-loaded rats regularly secrete potassium in excess of the amount filtered. Ouabain completely blocks the secretion of potassium by these isolated kidneys, suggesting that Na-K-ATPase mediates potassium secretion by potassium-adapted rats. Neither sodium deprivation, pretreatment with deoxycorticosterone, nor pretreatment with methylprednisolone prepared the kidney to secrete potassium, despite stimulation of Na-K-ATPase activity in cortex or outer medulla. Potassium loading was the only maneuver tested that increased the activity of Na-Katpase in the inner medulla (white papilla) and also produced potassium secretion by the isolated kidney. Surgical ablation of the papilla abolished the net secretion of potassium normally seen in perfused kidneys of potassium-adapted rats, thus underlining the importance of the papilla in the process of potassium adaptation.
A Tribute to Edward Huth, Editor
Authors: John R. Ball
Journal: Annals of Internal Medicine (1990)

Editorials15 June 1990A Tribute to Edward Huth, EditorFREEJohn R. Ball, MD, JDJohn R. Ball, MD, JDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-12-893 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis symposium is intended as a tribute to Ed Huth, a tribute combining three elements of high importance to Ed: words, the medical journal, and his friends and colleagues.A symposium in which papers are given, words spoken, was chosen as the proper vehicle because words have been Ed's instrument and he has done much to uphold the value of explicitness and clarity of expression. In an era in which even popular music is consumed in video form, the written word remains most powerful in keeping honest the debate of complex matters.The topic of the symposium—the medical journal—was easily...References1. Case K. Introduction of meritorious award winner. CBE Views. 1987;4:54. Google Scholar2. Huth E. Medical Style and Format: An International Manual for Authors, Editors, and Publishers. Philadelphia: ISI Press; 1987. Google Scholar3. Huth E. How to Write and Publish Papers in the Medical Sciences. 2d ed. Philadelphia: ISI Press; 1990. Google Scholar4. . Uniform requirements for manuscripts submitted to biomedical journals. Ann Intern Med. 1979;90:95-9. LinkGoogle Scholar5. Davies N. Edward J. Huth to retire: the search begins for his successor. Ann Intern Med. 1988;109:611. LinkGoogle Scholar6. Huth E. J. R. Elkinton and the editorial road. Ann Intern Med. 1971;75:128-30. LinkGoogle Scholar7. Huth E. What has become of the cuspidor? Ann Intern Med. 1964;60:163-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John R. Ball, MD, JDAffiliations: American College of Physicians PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIn Memoriam: Dr. Edward J. Huth Christine Laine Metrics Cited byIn Memoriam: Dr. Edward J. HuthChristine Laine, MD, MPH 15 June 1990Volume 112, Issue 12Page: 893-895 ePublished: 1 December 2008 Issue Published: 15 June 1990 PDF downloadLoading ...
Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus.
Authors: A Kretz-Rommel, S R Duncan, R L Rubin
Journal: Journal of Clinical Investigation (1997)

A side effect of therapy with procainamide and numerous other medications is a lupus-like syndrome characterized by autoantibodies directed against denatured DNA and the (H2A-H2B)-DNA subunit of chromatin. We tested the possibility that an effect of lupus-inducing drugs on central T cell tolerance underlies these phenomena. Two intrathymic injections of procainamide-hydroxylamine (PAHA), a reactive metabolite of procainamide, resulted in prompt production of IgM antidenatured DNA antibodies in C57BL/6xDBA/2 F1 mice. Subsequently, IgG antichromatin antibodies began to appear in the serum 3 wk after the second injection and were sustained for several months. Specificity, inhibition and blocking studies demonstrated that the PAHA-induced antibodies showed remarkable specificity to the (H2A-H2B)-DNA complex. No evidence for polyclonal B cell activation could be detected based on enumeration of Ig-secreting B cells and serum Ig levels, suggesting that a clonally restricted autoimmune response was induced by intrathymic PAHA. The IgG isotype of the antichromatin antibodies indicated involvement of T cell help, and proliferative responses of splenocytes to oligonucleosomes increased up to 100-fold. As little as 5 microM PAHA led to a 10-fold T cell proliferative response to chromatin in short term organ culture of neonatal thymi. We suggest that PAHA interferes with self-tolerance mechanisms accompanying T cell maturation in the thymus, resulting in the emergence of chromatin-reactive T cells followed by humoral autoimmunity.
Diagnosis of lymphogranuloma venereum from biopsy samples
Authors: I M C Martin
Journal: Gut (2006)

Objective This study investigated the diagnostic value of medical thoracoscopy in patients with the absence or a small amount of pleural effusion. <b>Methods:</b> From July 2019 to January 2020, 10 patients confirmed absence or a small amount of pleural effusion by CT scan were included in the study. MTs were performed without inducing a pneumothorax and ultrasound guidance. The operation process, clinical manifestations and pathological results were analyzed. <b>Results:</b> A total of 10 patients (median age 51.70±8.92 years) were included in the study, including 4 males and 6 females. There were 4 cases without pleural effusion and 6 cases with minimal pleural effusion. 9 patients were diagnosed pathologically, another one was diagnosed as nonspecific pleurisy, 7 of them were diagnosed as malignant tumor. There was no serious adverse reactions and serious complication during and after the operation. A small amount of bleeding occurred in one case, no bleeding and hemoptysis during and after the operation. Slight pain around incision site occurred in two cases, and only one patient had a fever after the operation. The drainage tube was normally removed within 12 hours in nine patients, 1 patient delayed extubation due to drainage of pleural fluid. <b>Conclusions:</b> For patients with pleural disease without pleural effusion or a small amount of pleural effusion, when the pleural biopsy by other procedures is at an increased risk of complications, medical thoracoscopy could be valuable and safe.
SOME COMPLICATIONS RESULTING FROM RECTAL OPERATIONS.
Authors: WILLIAM M. BEACH
Journal: JAMA (1899)

To sacrifice the minimum tissue and preserve the perfect function of an organ is the highest art in an operation for the eradication of disease. This proposition is especially germane to operative measures involving the anorectal region, for the reason that the mutilation of a single anatomic structure may determine disastrous sequences in the health and comfort of the patient. The notion is wide-spread in the profession, and taught by proctologic writers, that bold incisions and dissections of this region entail no permanent loss of function, trusting to the reparative processes of Nature to restore perfect order out of chaos. Legitimate surgery of the anus and rectum involves the consideration of certain anatomic landmarks that must not be disregarded. Martin writes: "The three typical visible topographic features of the anal rectum are the white line of Hilton, the pecten of Stroud, or anal pilasters and the linea dentata." The integumentary
Transfusion-transmitted hepatitis E in Germany, 2013
Authors: D Huzly, M Umhau, D Bettinger, T Cathomen, F Emmerich, P Hasselblatt, H Hengel, R Herzog, O Kappert, S Maassen, E Schorb, C Schulz-Huotari, R Thimme, R Unmüssig, J J Wenzel, M Panning
Journal: Eurosurveillance (2014)

The reported IgG seroprevalence against hepatitis E virus (HEV) in German blood donations is 6.8%, and HEV RNA detected in 0.08%, but documented evidence for HEV transmission is lacking. We identified two donations from a single donor containing 120 IU HEV RNA/mL plasma and 490 IU/mL. An infectious dose of 7,056 IU HEV RNA was transmitted via apheresis platelets to an immunosuppressed patient who developed chronic HEV. Further, transmission was probable in an immunocompetent child.
Dose ranging, expanded acute toxicity and safety pharmacology studies for intravenously administered functionalized graphene nanoparticle formulations
Authors: Shruti Kanakia, Jimmy D. Toussaint, Sayan Mullick Chowdhury, Tanuf Tembulkar, Stephen Lee, Ya-Ping Jiang, Richard Z. Lin, Kenneth R. Shroyer, William Moore, Balaji Sitharaman
Journal: Biomaterials (2014)
The flip-flop HuR: part of the problem or the solution in fighting cancer?
Authors: Jacqueline C. Shultz, Charles E. Chalfant
Journal: Journal of Clinical Investigation (2011)

Chronic inflammation has long been appreciated to play a critical role in tumor development and maintenance. Among the mechanisms involved in coordinating the initiation and resolution of inflammation are those responsible for modifying mRNA stability and/or translation. Several studies have linked the RNA-binding protein HuR, which increases mRNA stability, with malignant transformation. However, in this issue of the JCI, Yiakouvaki et al. compellingly demonstrate in mice that increased HuR activity in myeloid cells has a protective role in the onset of pathologic intestinal inflammation (i.e., colitis) and colitis-associated cancer (CAC). These observations highlight the need to understand the roles of HuR in distinct cell populations in vivo and suggest that enhancing HuR activity may be of clinical benefit in protecting against pathologic inflammation and cancer.
Silent Myocardial Ischemia
Authors: David A. Silverstein
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 December 1988Silent Myocardial IschemiaDavid A. Silverstein, MDDavid A. Silverstein, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-11-923 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In his article on silent myocardial ischemia, Dr. Cohn (1) clearly describes the mechanisms, diagnosis, and prognosis of this condition. In his recommendations for screening and management, however, he ignores his conclusion that the benefits of treatment remain unproved. Although the benefits of treatment are unproved, the potential for doing harm is great, particularly in patients with type 1 (asymptomatic) ischemia.Cohn recommends screening exercise tests for asymptomatic persons with two or more risk factors for coronary artery disease. For persons with positive test results that show less than 2 mm of ST depression, he recommends confirmation...References1. Cohn P. Silent myocardial ischemia. Ann Intern Med. 1988;109:312-7. LinkGoogle Scholar2. Kannel W. Some lessons in cardiovascular epidemiology from Framingham. Am J Cardiol. 1976;37:269-82. CrossrefMedlineGoogle Scholar3. DetranoFroelicher RV. A logical approach to screening for coronary artery disease. Ann Intern Med. 1987;106:846-52. LinkGoogle Scholar4. PassamaniDavisGillespieKillip EKMT. A randomized trial of coronary artery bypass surgery: survival of patients with a low ejection fraction. N Engl J Med. 1985;312:1665-71. CrossrefMedlineGoogle Scholar1. Cohn P. Silent myocardial ischemia. Ann Intern Med. 1988;109:312-7. LinkGoogle Scholar1. BermanRozanskiKnoebel DAS. The detection of silent ischemia: cautions and precautions. Circulation. 1987;75:101-5. CrossrefMedlineGoogle Scholar2. DetranoFroelicher RV. A logical approach to screening for coronary artery disease. Ann Intern Med. 1987;106:846-52. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDiagnosis of silent myocardial ischemia using ambulatory electrocardiographic monitoring with pedometer, analysis of heart rate, and ST loop in ambulatory electrocardiogramSilicon Nitride in Compound Semiconductor Field Effect TransistorsAn update to silent myocardial ischemia: Pathophysiological, diagnostic, and therapeutic approaches 1 December 1988Volume 109, Issue 11Page: 923-924KeywordsExerciseIschemiaMedical risk factorsStable coronary artery disease Issue Published: 1 December 1988 PDF DownloadLoading ...
STUDIES OF DNA-INDUCED HERITABLE ALTERATION OF MAMMALIAN CELLS
Authors: Ellen Borenfreund, Yuji Honda, Mildred Steinglass, Aaron Bendich
Journal: The Journal of Experimental Medicine (1970)

An intercellular interaction between mouse Ehrlich ascites tumor and non-malignant Chinese hamster cells occurred when these were co-cultured. That the intercellular processes which formed had emanated from the EA cells was revealed by immunofluoroscopy using anti-EA antiserum, and by direct microscopic examination. A passage of DNA from the EA to the CH cells was also observed. On long-term co-culture, new cell forms arose which were isolated, cloned, and propagated. They showed a CH karyotype and had acquired oncogenic potential and the ability to synthesize murine-specific antigens. These same heritable properties were also acquired by CH cells following their exposure to DNA isolated from EA cells.
Precordial Movement in Pulmonary Stenosis.
Authors: Ernest Craige
Journal: Annals of Internal Medicine (1965)

s1 May 1965Precordial Movement in Pulmonary Stenosis.Ernest Craige, M.D., F.A.C.P., Roland Schmidt, M.D.Ernest Craige, M.D., F.A.C.P.Search for more papers by this author, Roland Schmidt, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1072_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrecordial movements along the left sternal border have been recorded in normal children and in children with congenital heart disease in an effort to improve the accuracy of diagnosis by external, nontraumatic methods. Displacement tracings were obtained by means of an Infraton capacitance transducer or a piezo-electric method, with excellent response in the ultra low frequency range.The normal record, based on a study of 60 children, showed: (1) an initial outward movement during ventricular contraction which had a duration of 0.25 second or less; (2) a succeeding inward movement that exceeded the initial outward movement in magnitude; (3) a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Ernest Craige, M.D., F.A.C.P.; Roland Schmidt, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1072-1073KeywordsChildrenCongenital heart diseaseStenosis ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...
"Epilepsy of Syphilitic Origin."
Authors: Theodore Diller
Journal: JAMA (1905)

Pittsburg, June 9, 1905.  To the Editor:  —The statement of Dr. John T. Moore inThe Journal, June 10, p. 1855, that practically all authorities agree that epilepsy, coming on during adult life, unless directly traceable to injury, should be regarded as syphilitic in character ought not to pass without protest. Certainly the possibility of syphilis should be carefully considered; but there are other causes, among them innocent arteriosclerosis certainly may be reckoned and it would be wrong to give prolonged antisyphilitic treatment in all cases of epilepsy in which the attacks first appear in adult life and which are not traceable to injury.
Cardiac Disease, Hepatic Disease, and Hepatitis B Antigen
Authors: Alan B. Miller, David M. Waggoner
Journal: Annals of Internal Medicine (1973)

Letters1 August 1973Cardiac Disease, Hepatic Disease, and Hepatitis B AntigenALAN B. MILLER, M.D., DAVID M. WAGGONER, M.D.ALAN B. MILLER, M.D.Search for more papers by this author, DAVID M. WAGGONER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-2-276_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The association of heart disease with infectious hepatitis is well known, but recent reviews (1, 2) fail to mention any relation of cardiac disease to hepatic disease associated with hepatitis B antigen (HB Ag). The presence of HB Ag correlates with long incubation or serum hepatitis. We recently saw two patients with documented cardiac abnormalities and HB Ag.Patient K.A., a 42-year-old white man, was admitted to Cleveland Metropolitan General Hospital with a 2-week history of nausea, dark urine, anorexia, an 8-lb weight loss, and diffuse joint pain. He denied any history of previous heart disease, transfusions,...References1. SUNSMITH NW: Hepatitis associated with myocarditis. N Engl J Med 274:190-193, 1966 CrossrefMedlineGoogle Scholar2. BELL H: Cardiac manifestations of viral hepatitis. JAMA 218:387-391, 1971 CrossrefMedlineGoogle Scholar3. BLUMBERGSUTNICKLONDON BAW: Australian antigen and hepatitis. N Engl J Med 283:349-354, 1970 CrossrefMedlineGoogle Scholar4. LEBOUVIER G: The heterogenicity of Australian antigen. J Infect Dis 123:671-675, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHepatobiliary disease: Medical emergenciesImmunopathogenesis of the Extrahepatic Manifestations of Hepatitis B Virus InfectionImmunopathogenesis of the extrahepatic manifestations of hepatitis B virus infection 1 August 1973Volume 79, Issue 2Page: 276-276KeywordsAntigensCardiovascular therapyHeart diseasesHepatitisHepatitis BInfectious diseasesInfectious hepatitisNauseaUrineWeight loss Issue Published: 1 August 1973 PDF DownloadLoading ...