tbuckley/cabot-search huggingface dataset:
Peptide Dendrimer–Doxorubicin Conjugate‐Based Nanoparticles as an Enzyme‐Responsive Drug Delivery System for Cancer Therapy
Authors: Chengyuan Zhang, Dayi Pan, Kui Luo, Wenchuan She, Chunhua Guo, Yang Yang, Zhongwei Gu
Journal: Advanced Healthcare Materials (2014)

Peptide dendrimers have shown promise as an attractive platform for drug delivery. In this study, mPEGylated peptide dendrimer–doxorubicin (dendrimer–DOX) conjugate‐based nanoparticle is prepared and characterized as an enzyme‐responsive drug delivery vehicle. The drug DOX is conjugated to the periphery of dendrimer via an enzyme‐responsive tetra‐peptide linker Gly‐Phe‐Leu‐Gly (GFLG). The dendrimer–DOX conjugate can self‐assemble into nanoparticle, which is confirmed by dynamic light scattering, scanning electron microscopy, and transmission electron microscopy studies. At equal dose, mPEGylated dendrimer–DOX conjugate‐based nanoparticle results in significantly high antitumor activity, and induces apoptosis on the 4T1 breast tumor model due to the evidences from tumor growth curves, an immunohistochemical analysis, and a histological assessment. The in vivo toxicity evaluation demonstrates that nanoparticle substantially avoids DOX‐related toxicities and presents good biosafety without obvious side effects to normal organs of both tumor‐bearing and healthy mice as measured by body weight shift, blood routine test, and a histological analysis. Thus, the mPEGylated peptide dendrimer–DOX conjugate‐based nanoparticle may be a potential nanoscale drug delivery vehicle for the breast cancer therapy.
Wide Complex Tachycardia and Adenosine
Authors: Joseph L. Schuller, Paul D. Varosy, Duy Thai Nguyen
Journal: JAMA Internal Medicine (2013)

A 46-year-old African American woman with a history of palpitations presented to the emergency department with right chest discomfort and a racing pulse. A 12-lead electrocardiogram (ECG) was obtained (Figure 1). She had a recent echocardiogram showing a structurally normal heart.
Flow cytometric immunobead assay for the detection of BCR–ABL fusion proteins in leukemia patients
Authors: F Weerkamp, E Dekking, Y Y Ng, V H J van der Velden, H Wai, S Böttcher, M Brüggemann, A J van der Sluijs, A Koning, N Boeckx, N Van Poecke, P Lucio, A Mendonça, L Sedek, T Szczepański, T Kalina, M Kovac, P G Hoogeveen, J Flores-Montero, A Orfao, E Macintyre, L Lhermitte, R Chen, K A J Brouwer-De Cock, A van der Linden, A L Noordijk, W M Comans-Bitter, F J T Staal, J J M van Dongen
Journal: Leukemia (2009)
Case of Rupture of the Uterus: Abdominal Section: Subsequent Pregnancies
Authors: S. S. Dyer
Journal: BMJ (1865)

Britith Medical Journal-3t ORIGINAL POX)t C. portion of the blood, that the practice of giving opium and other astringents, to arrest the intestinal discharges will continue more or less, in spite of W4re and disa~pointmeut,' until it can be clearly s1own that the state of collapse haa an entirely different origins and eause from that which the theory in question assumes.[To be continued.
Depot-Specific Differences and Insufficient Subcutaneous Adipose Tissue Angiogenesis in Human Obesity
Authors: Olga Gealekman, Nina Guseva, Celia Hartigan, Sarah Apotheker, Matthew Gorgoglione, Kunal Gurav, Khanh-Van Tran, Juerg Straubhaar, Sarah Nicoloro, Michael P. Czech, Michael Thompson, Richard A. Perugini, Silvia Corvera
Journal: Circulation (2011)

Background— Adipose tissue expands in response to excess caloric intake, but individuals prone to deposit visceral instead of subcutaneous adipose tissue have higher risk of metabolic disease. The role of angiogenesis in the expandability of human adipose tissue depots is unknown. The objective of this study was to measure angiogenesis in visceral and subcutaneous adipose tissue and to establish whether there is a relationship between obesity, metabolic status, and the angiogenic properties of these depots. Methods and Results— Angiogenic capacity was determined by quantifying capillary branch formation from human adipose tissue explants embedded in Matrigel, and capillary density was assessed by immunohistochemistry. Subcutaneous adipose tissue had a greater angiogenic capacity than visceral tissue, even after normalization to its higher initial capillary density. Gene array analyses revealed significant differences in expression of angiogenic genes between depots, including an increased subcutaneous expression of angiopoietin-like protein 4, which is proangiogenic in an adipose tissue context. Subcutaneous capillary density and angiogenic capacity decreased with morbid obesity, and subcutaneous, but not visceral, adipose tissue angiogenic capacity correlated negatively with insulin sensitivity. Conclusions— These data imply that subcutaneous adipose tissue has a higher capacity to expand its capillary network than visceral tissue, but this capacity decreases with morbid obesity. The decrease correlates with insulin resistance, suggesting that impairment of subcutaneous adipose tissue angiogenesis may contribute to metabolic disease pathogenesis.
Sports drinks adverts are banned for false claims
Authors: D. Cohen
Journal: BMJ (2014)

An advertising campaign claiming that the sports drink Lucozade Sport “hydrates and fuels you” better than water has been banned across the UK.

The Advertising Standards Authority received 63 complaints—including one from the Natural Hydration Council—about the television and poster adverts featuring Real Madrid’s Gareth Bale and the captain of Harlequin’s rugby union team, Chris Robshaw, saying they breached the advertising code.

The television advertisement showed two groups of men, one drinking water and the other drinking Lucozade Sport, running on treadmills while being monitored by technicians.

A voiceover then said: “At the limits of your ability you need to replace the electrolytes you lose in sweat, keep …
Acute Surgical Emergencies of the Abdomen in Pregnancy
Authors: Edward Hamlin, Marshall K. Bartlett, Judson A. Smith
Journal: New England Journal of Medicine (1951)

THE experiences of the Boston Lying-in Hospital with acute surgical emergencies from 1916 to 1939 have been reported.§ Because of the subsequent introduction of newer methods of therapy and in order to answer questions concerning the effect of pregnancy on acute abdominal conditions and the effect of acute abdominal conditions on pregnancy, it has been thought advisable to add the experiences of the Boston Lying-in Hospital with acute surgical emergencies for the years 1939–1948 to those already published.As in the previous report, ectopic pregnancies and traumatic ruptures of the uterus during delivery have been excluded.Table 1 lists the various acute . . .
The cancer emperor's new clothes: Australia's historic legislation for plain tobacco packaging
Authors: S. Chapman, B. Freeman
Journal: BMJ (2010)

The Australian government has announced one of the most important chronic disease prevention policies ever adopted. From 2012 all tobacco products will be sold in standardised plain packs (see News, BMJ 2010;340:c2401, doi:10.1136/bmj.c2401). The opposition Liberal party is not opposing the move. Plain packs will be uniform in colour, shape, and texture of paper. Pictorial health warnings will remain and may increase in size, and brands will be differentiated only by their names in a small, standard font (figure⇓). The legislation comes after other recent Australian state legislation banning the retail display of tobacco products.



Cigarettes themselves may also be incorporated into the regulations, so that coloured or perfumed papers and filters and different shapes such as slimline and mini-cigarettes would be outlawed. With a worldwide domino effect common in tobacco control, this vanguard decision may bring down the curtain on a century of the tobacco industry packaging carcinogenic, addictive products in attractive, beguiling boxes. The cancer emperor will soon have no clothes.

Although drugs have long been sold in packs devoid …
MALARIAL THERAPY IN DEMENTIA PARALYTICA
Authors: H. R. UNSWORTH
Journal: JAMA (1930)

The De Paul Sanitarium in New Orleans, an institution for the treatment of nervous and mental disorders, is advantageously situated in regard to climate and for securing malarial organisms. Rarely is it necessary to wait any prolonged period of time before obtaining the tertian type of organisms used in this work. It is also noteworthy that we get cases that are not of the usual state institutional type; that is, dilapidated patients, but also cerebrospinal syphilitic patients who are just beginning to manifest psychic symptoms of dementia paralytica and in whom serologic examination reveals early changes in the paretic zone in the colloidal gold test. On account of this wide variance in the grade of patients with dementia paralytica it has given me an opportunity to conclude distinctly that malarial therapy is undoubtedly best in these early cases and that little improvement may be expected from those in the late
p-Cresol: cause of ink-induced hair depigmentation in mice
Authors: WALTER B. SHELLEY
Journal: British Journal of Dermatology (1974)

p‐Cresol has been identified as the active chemical in a laundry‐ink responsible for the previously reported contact depigmentation of hair in agouti CBA/J mice. p‐Cresol has been shown to induce depigmentation of both skin and hair in agouti as well as black mice. In the agouti mice there were bands and whorls, as well as plaques of white hair. However, the most striking finding was an occult hair depigmentation wherein the new hair shafts were white except for the tips. Such pigment‐loss was not apparent on surface examination of the fur, becoming evident only on parting the hairs. All of these patterned hair pigment losses have been related to a unique sensitivity of the follicular melanocytes to the toxic effect of p‐cresol during the earliest days of new hair formation, that is, during the initial anagen phase.
Relationship of one form of human histamine-releasing factor to connective tissue activating peptide-III.
Authors: M L Baeza, S R Reddigari, D Kornfeld, N Ramani, E M Smith, P A Hossler, T Fischer, C W Castor, P G Gorevic, A P Kaplan
Journal: Journal of Clinical Investigation (1990)

We have previously reported purification of three forms of histamine-releasing factors (HRFs) from mixtures of streptokinase-streptodornase stimulated human mononuclear cells and platelets with apparent molecular masses of 10-12, 15-17, and 40-41 kD (1989. J. Clin. Invest. 83:1204-1210). We have also prepared mouse MAbs against the 10-12-kD HRF (1989. J. Allergy Clin. Immunol. 83:281). Affinity-purified 10-12-kD HRF appears as a broad band upon polyacrylamide gel electrophoresis in the presence of SDS. We determined the NH2-terminal amino acid sequence of the top and bottom halves of this broad band. Sequence analysis revealed striking homology between this HRF and connective tissue activating peptide-III (CTAP-III), a platelet-derived 8-10-kD protein known to cause mitogenesis and extracellular matrix formation in fibroblast cultures. 19 of 21 NH2-terminal residues in the top half of the HRF band were identical to the NH2-terminal sequence of CTAP-III. 20 of 21 NH2-terminal residues in the bottom half were identical to the NH2-terminal sequence of neutrophil-activating peptide-2, which is derived from CTAP-III by proteolytic cleavage between residues 15 and 16. Purified CTAP-III also released histamine from basophils. Rabbit antiserum raised against either native or recombinant CTAP-III recognized affinity-purified HRF in immunodot blot assays, and MAb against HRF recognized CTAP-III in both dot blot and microtiter plate based immunoassays. These data demonstrate the first structural, functional, and immunologic relationship between one form of human HRF and a previously described cell product.
Tweaking Proposed Food Safety Rules
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergy to the coffee plant
Authors: I G Axelsson
Journal: Allergy (1994)

Occupational respiratory allergy to green coffee beans in coffee roastery workers is well established. I now report on a 50‐year‐old female atopic patient sensitized to the coffee plant used for indoor decoration. The symptoms were rhinitis and conjunctivitis on exposure to the plant. Investigation showed a positive skin prick test, RAST, and rhinoconjunctival provocation test to coffee leaf allergen extract. However, the commercially available RAST disk for green coffee beans seems to be appropriate for diagnosing allergy to the potted coffee plant.
Including care home residents in clinical research is fraught
Authors: Arnold G Zermansky
Journal: BMJ (2005)

EDITOR—Funders need to take account of issues related to including older people in clinical trials,1 but including care home residents poses additional problems.

We have just completed a large clinical trial of a pharmacist conducting clinical medication reviews of elderly residents of care homes. Obtaining consent presented particular problems in this population with an average age of 85 and a standardised mini-mental state test score of 13. Even those …
Treatment of External Auditory Canal
Authors: B. G. McKibben
Journal: JAMA (1961)

<h3>To the Editor:—</h3> I should like to elaborate on the answer given by Dr. Fowler for the Question and Answer regarding the external auditory canal (<b>JAMA 176</b>:1066 [June 24] 1961). I am fully in accord with what he has said, but believe that it should be pointed out that the temperature of the water which is used to lavage the ear canal should be approximately body temperature. It is quite possible that the reader would think that warm water might by 105°F., and this, of course, would probably give the patient a caloric response with dizziness and possibly nausea and vomiting.
Effects of pretreatment with inhaled methoxamine on bronchial responses to histamine in asthmatic subjects
Authors: TT Phan-Puibaraud, J Regnard, M Monchi, J Dall'Ava-Santucci, A Lockhart, AT Dinh-Xuan
Journal: European Respiratory Journal (1995)

The underlying mechanisms of bronchial obstruction in asthma are complex. Both bronchospasm and bronchial oedema are thought to play pivotal roles in asthma, but their respective importance in a given asthmatic individual is unknown. To address this question, we assessed the effects of pretreatment with inhaled methoxamine, a potent alpha 1-adrenoceptor agonist, on bronchial response to inhaled histamine in 10 asthmatic subjects. The study was conducted according to a double-blind, cross-over, randomized and placebo-controlled design. In each subject, dose-response curves for the effects on forced expiratory volume in one second (FEV1) of serially doubling doses of inhaled histamine were obtained on three different days, 15 min after pretreatment with either methoxamine (10 mg) or duplicated placebo. Histamine, first dose 100 micrograms (543 nmol), was delivered by a breath-activated dosimeter every 5 min. FEV1 was measured in triplicate after each dose and the largest value was retained. There was no difference in baseline and prechallenge FEV1 after placebo and methoxamine. Mean coefficient of variation of decrease in FEV1 induced by histamine on the two placebo days was 6.7 +/- 2%. On average, the bronchial responses to histamine were not modified by pretreatment with methoxamine as compared to placebo (delta FEV1 = 0.83 +/- 0.14 l on methoxamine versus 0.85 +/- 0.11 l and 0.86 +/- 0.13 l on the two placebo days).(ABSTRACT TRUNCATED AT 250 WORDS)
P544 CLINICAL USEFULLNESS OF PRIMOVIST-MRI ON INITIAL STAGING WORKUP IN HEPATOCELLULAR CARCINOMA PATIENTS WHO ARE CANDIDATES FOR CURATIVE TREATMENTS ON LIVER DYNAMIC CT
Authors: Y.-J. Jin, J.-W. Lee, H.J. Chung, Y.S. Kim, S.G. Cho, Y.S. Jeon
Journal: Journal of Hepatology (2014)
The Post-Physician Era: Medicine in the 21st Century
Authors: Philip C. Anderson
Journal: JAMA (1977)

Even the monthly science fiction magazines demand more intellectual insight, a more mature viewpoint, and a better logical projection than this tiresome offering. Reviving a discussion popular 20 years ago, Maxmen predicts that physicians soon will become extinct, to be replaced by a giant system of computers assisted by inexpensive medics who can solve the enormous and ugly problems of the present-day medical system. If Maxmen understood these enormous problems and could show sympathy and much more humor, then the book might have become a pleasant fantasy or even a satire, but he achieves much less impact with this unsubstantiated, cultish forecast. A more sophisticated intellect could scald present-day politicians, consumers, and medical leaders with criticism based on the methods of forecasting and analysis and could include some useful understanding of incentives, governmental authority, comparable projected costs, alternative futures, and workable methods of implementation or control. A valid tradition of
Altered properties of erythrocytes in the aged
Authors: Nechama S. Kosower
Journal: American Journal of Hematology (1993)

Abstract Erythrocytes in the aged have a decreased life span. The properties of the red blood cells of old individuals are compared to those of the cells of young individuals. In young individuals, removal of the normal erythrocyte at the end of its lifespan is determined by a signal(s) due to (1) modified phospholipids, (2) modified carbohydrate residues, and/or (3) modified proteins. Similar changes may occur in the erythrocytes of old individuals but at a greater rate. In particular, the enhanced degradation of band 3 protein by calpain may provide a senescence signal. © 1993 Wiley‐Liss, Inc.
The Treatment of Glaucoma by the Application of Ice
Authors: H. Greenway
Journal: BMJ (1880)

doubt, be something interesting; but, as yet, I have been unable to find the paper.Next to Dr. Budd's works upon cholera and typhoid, his communica- tions and his pamphlet on scarlet fever and on cattle-plague and its prevention will perhaps be considered most important; and I have a reference to a paper published on cattle-plague in the Medical Timies and Gazetle for I865.He was undoubtedly the originator of the plan that was, after long discussion and much severe criticism of the author of it, adopted all through the country, and made compulsory by an Act of the Privy Council.He was a member of the Commission of the Privy Council on the Cattle-Plague.His views on cattle-plague were largely discussed in one society, and for a long time he was connected with the pole-axe and the lime-pit in the minds of many.For this, and for much other work of a public character, which will continue to confer immense benefits upon mankind, I have long been of opinion, and I have often heard the same opinion expressed by others, that Dr. Budd more than earned one of those pensions which are given by a grateful country to unusual services.But Dr. Budd died
Critical Values in Medical Education
Authors: Richard H. Moy
Journal: New England Journal of Medicine (1979)

I AM sure that an excellent case could be made by some unfriendly person that there are no critical values in medical education, only those priorities assigned by physicians and deans out of an instinct for self-preservation. Acknowledging ownership of the adjective "critical," I must then admit two biases or assumptions from which values and issues derive that are of importance to me. These assumptions are: first, that there is a need for physicians, and second, that education makes a difference. I will expand on these two assumptions and present implications that I believe are important for the curriculum, the . . .
Flaws Documented, Reforms Debated at Congress on Journal Peer Review
Authors: Paul Cotton
Journal: JAMA (1993)

RESEARCH is revealing much room for improvement in the long-concealed world of medical journal peer review. A host of shortcomings, from bias and error to poor readability and a lack of clear standards, were documented in studies presented at the Second International Congress on Peer Review in Biomedical Publication, held in Chicago, Ill. See also p 2856. The meeting, sponsored by the American Medical Association, was designed "to stimulate research, not rehash editorial opinion," says congress director Drummond Rennie, MD, Deputy Editor (West),<i>JAMA</i>, Chicago, Ill. "We are looking closely for information we can put into practice" to improve "and, if necessary, reinvent" medical journals, says George D. Lundberg, MD, Editor,<i>JAMA</i>. <h3>Need for Standards</h3> Despite Rennie's call to focus on research, calls for establishing standards peppered the meeting. Speakers cited a need for clear statements of the types of reasons papers are rejected, what is expected from reviewers, how
A Comprehensive Survey of Healthcare Professionals and Asthma Patients Offering Insight on Current Treatment Gaps and Emerging Device Options (C.H.O.I.C.E.) Study: Patient Perception of Symptom Control
Authors: N.K. Ostrom, R.A. Nathan, R. Lanier, R. Anolik, G. Colice, P. Marcus, J. Schwartz, D.E. Geller, M. Blaiss
Journal: Journal of Allergy and Clinical Immunology (2010)
A Computational Workflow to Identify Allele-Specific Expression and Epigenetic Modification in Maize
Authors: Xiaoxing Wei, Xiangfeng Wang
Journal: Genomics Proteomics & Bioinformatics (2013)

Abstract Allele-specific expression refers to the preferential expression of one of the two alleles in a diploid genome, which has been thought largely attributable to the associated cis-element variation and allele-specific epigenetic modification patterns. Allele-specific expression may contribute to the heterosis (or hybrid vigor) effect in hybrid plants that are produced from crosses of closely-related species, subspecies and/or inbred lines. In this study, using Illumina high-throughput sequencing of maize transcriptomics, chromatic H3K27me3 histone modification and DNA methylation data, we developed a new computational framework to identify allele-specifically expressed genes by simultaneously tracking allele-specific gene expression patterns and the epigenetic modification landscape in the seedling tissues of hybrid maize. This approach relies on detecting nucleotide polymorphisms and any genomic structural variation between two parental genomes in order to distinguish paternally or maternally derived sequencing reads. This computational pipeline also incorporates a modified Chi-square test to statistically identify allele-specific gene expression and epigenetic modification based on the Poisson distribution.