tbuckley/cabot-search huggingface dataset:
Anti-CD137 Monoclonal Antibody Administration Augments the Antitumor Efficacy of Dendritic Cell-Based Vaccines
Authors: Fumito Ito, Qiao Li, Andrew B. Shreiner, Ryuji Okuyama, Maria N. Jure-Kunkel, Seagal Teitz-Tennenbaum, Alfred E. Chang
Journal: Cancer Research (2004)

Abstract In weakly and poorly immunogenic tumor models, we examined the effects of stimulating CD137 (4-1BB) in vivo by administering anti-CD137 monoclonal antibody after tumor lysate-pulsed dendritic cell (TP-DC) vaccination. TP-DC subcutaneous vaccination induced a transient up-regulation of CD137 on T cells and natural killer (NK) cells within vaccine-primed lymph nodes (VPLNs). In established pulmonary and subcutaneous tumor models, anti-CD137 synergistically enhanced tumor regression after TP-DC vaccination. In the subcutaneous tumor model, the combined therapy resulted in improved survival. Combined therapy also resulted in improved local control of subcutaneous tumor after surgical resection. Anti-CD137 polarized the cytokine release of VPLNs and spleen cells in response to tumor antigen toward a type 1 (interferon-γ) versus a type 2 (interleukin-4) profile. Cell depletion and the use of knockout animals identified that CD8+, CD4+, and NK cells were involved in the tumor rejection response and that CD8+ cells had the major effector role. Anti-CD137 administration resulted in increased proliferation of adoptively transferred OT-1 CD8+ T cells in the VPLNs of mice inoculated with B16-OVA TP-DCs. Polarization toward type 1 (interferon-γ) versus type 2 (interleukin-4) was also observed with the OT-1 cells from VPLNs and spleen cells after anti-CD137 injections. This polarization effect was abrogated by the in vivo depletion of NK cells. These findings indicate that the adjuvant effect of anti-CD137 given in conjunction with TP-DC vaccination is associated with the polarization of T effector cells toward a type 1 response to tumor antigen and is mediated via NK cells.
Enhanced repair of large osteochondral defects using a combination of artificial cartilage and basic fibroblast growth factor
Authors: Aki Fukuda, Ko Kato, Masahiro Hasegawa, Hitoshi Hirata, Akihiro Sudo, Kenshi Okazaki, Kaoru Tsuta, Yasuo Shikinami, Atsumasa Uchida
Journal: Biomaterials (2004)
INTRACORONARY CARDIOSPHERE-DERIVED CELLS AFTER MYOCARDIAL INFARCTION: MAGNETIC RESONANCE IMAGING ANALYSIS OF REGENERATION AND DETERMINANTS OF EFFICACY IN THE FINAL 1-YEAR RESULTS OF THE CADUCEUS TRIAL
Authors: Konstantinos Malliaras, Ke Cheng, Rachel R. Smith, Edwin Wu, Robert Bonow, Adam Mendizabal, Gary Gerstenblith, Peter V. Johnston, Karl Schuleri, Albert C. Lardo, Linda Marbán, Rajendra Makkar, Eduardo Marbán
Journal: Journal of the American College of Cardiology (2013)
Serum electrolyte concentrations and hydration status are not associated with exercise associated muscle cramping (EAMC) in distance runners
Authors: M P Schwellnus, J Nicol, R Laubscher, T D Noakes
Journal: British Journal of Sports Medicine (2004)

Objectives: To determine whether acute exercise associated muscle cramping (EAMC) in distance runners is related to changes in serum electrolyte concentrations and hydration status. Methods: A cohort of 72 runners participating in an ultra-distance road race was followed up for the development of EAMC. All subjects were weighed before and immediately after the race. Blood samples were taken before the race, immediately after the race, and 60 minutes after the race. Blood samples were analysed for glucose, protein, sodium, potassium, calcium, and magnesium concentrations, as well as serum osmolality, haemoglobin, and packed cell volume. Runners who suffered from acute EAMC during the race formed the cramp group (cramp, n = 21), while runners with no history of EAMC during the race formed the control group (control, n = 22). Results: There were no significant differences between the two groups for pre-race or post-race body weight, per cent change in body weight, blood volume, plasma volume, or red cell volume. The immediate post-race serum sodium concentration was significantly lower (p = 0.004) in the cramp group (mean (SD), 139.8 (3.1) mmol/l) than in the control group (142.3 (2.1) mmol/l). The immediate post-race serum magnesium concentration was significantly higher (p = 0.03) in the cramp group (0.73 (0.06) mmol/l) than in the control group (0.67 (0.08) mmol/l). Conclusions: There are no clinically significant alterations in serum electrolyte concentrations and there is no alteration in hydration status in runners with EAMC participating in an ultra-distance race.
Immunohistochemical Distribution of Glucagon, Substance P and Vasoactive Intestinal Polypeptide in Hepatic Vasculature of the Rat
Authors: Yutaka Sasaki, Takenobu Kamada, Norio Hayashi, Nobuhiro Sato, Akinori Kasahara, Hideyuki Fusamoto, Sadao Shiosaka, Masaya Tohyama, Yahe Shiotani
Journal: Hepatology (1984)

The distribution of immunoreactive glucagon, substance P (SP) and vasoactive intestinal polypeptide (VIP)-like structures was investigated in the rat liver, with special reference to the hepatic vasculature by means of the indirect immunofluorescence method. Immunoreactive structures of glucagon were seen in the walls of the portal vein, hepatic artery and hepatic vein, but not in the central vein. Immunoreactive glucagon was localized in the smooth muscle cells of these blood vessels. SP and VIP-like immunoreactive (SPI and VIPI) structures were seen in the neuronal elements. In the porta hepatis, thick, compact SPI and VIPI fibers, which were dissociated from their fiber bundles, reached the tunica adventitia where they were distributed. No SPI and VIPI structures were seen in the tunica media or the tunica interna. No SPI- and VIPI-containing cell bodies could be detected in the liver. These observations suggest that these peptides may have an important role in the neural regulation of hepatic hemodynamics.
At a Cocktail Party With the Vietnamese Ambassador to the United States
Authors: Robert S. McKelvey
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MIGRATION OF A BULLET TERMINATING IN THE EPIDIDYMIS
Authors: John F. Hogan
Journal: JAMA (1931)

A patient was admitted to the South Baltimore General Hospital, July 15, 1930, with a history of having been shot while attempting to escape from a police officer four days prior to admission. On examination, a small round wound was found in the right gluteal region on a line with the fifth segment of the sacrum and about 4 cm. from its right border, another about 2 cm. from that, and a third just to the left of the left border of the fifth sacral segment. The first wound was the first port of entry of the bullet, the second wound a port of exit; then the bullet ricocheted over the sacrum and reentered the body in the same plane, that is, about a centimeter to the left of the left border of the fifth sacral segment, and took a course through the perineum, terminating in the lower part of
Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics
Authors: Stephane Belin, Homaira Nawabi, Chen Wang, Shaojun Tang, Alban Latremoliere, Peter Warren, Hubert Schorle, Ceren Uncu, Clifford J. Woolf, Zhigang He, Judith A. Steen
Journal: Neuron (2015)
Rich countries accused of breaking promises on debt
Authors: D. Logie
Journal: BMJ (2000)

As the people of Africa struggle to overcome famine, floods, and AIDS, criticism mounted last week that promises on debt cancellation made in Cologne last year by the World Bank and the International Monetary Fund are not being delivered.

Global finance ministers at the meetings of the International Monetary Fund and World Bank in Washington, DC, said that only five countries so far—Uganda, Bolivia, Mauritania, Tanzania, and Mozambique—will meet the requirements necessary to receive cancellation by April under the terms of the enhanced Highly …
Haemoperitoneum associated with a ruptured gall bladder.
Authors: P Atkins
Journal: BMJ (1967)

the estimation was performed.Jarnum and Jensen (1966) demonstrated protein-losing enteropathy in their patient.Five of the reported cases have had a fatal outcome (Cronkhite and Canada, 1955 ; Martini and Ddlle, 1961; Johnston, Vosburgh, Wiens, and Walsh, 1962 ; Jarnum and Jensen, 1966), usually within 18 months of the onset of the diarrhoea.Spontaneous clinical and biochemical remissions occurred in one patient ( Kennedy and Hirson, 1961).Two were improved by removal of the polypi-one by a gastrectomy (Manousus and Webster, 1966) and the other by a hemicolectomy (Zdansky and Riederer, 1963).Jejunal diverticulosis and pancreatic disease have not been previously reported in this condition and it is possible that these may be part of the syndrome.Jejunal diverticulosis is a well-recognized cause of intestinal malabsorption.Booth, Babouris, Hanna, and MacIntyre (1963) drew attention to the not uncommon finding of hypomagnes- aemia, which was present in 15 out of 42 cases of intestinal malabsorption of various causes reported in their series.An interesting feature in the present case is the presentation with paraesthesiae and convulsions due to hypocalcaemia and hypo- magnesaemia, and the later development of more generalized malabsorption despite symptomatic improvement and weight gain after treatment with oral supplements and broad-spectrum antibiotics.
David Ian Hewitt Simpson
Authors: A. J. H. Simpson
Journal: BMJ (2011)

Experience of the peroral, hydraulic, multiple, small-bowel biopsy instrument is recorded and compared with reported experience of other peroral biopsy instruments. It is concluded that, in routine clinical practice, there is no particular danger associated with this instrument despite warnings to the contrary. Furthermore, biopsies are obtained at least as quickly as with other instruments and with great reliability. Since this instrument also enables multiple, precisely located biopsies to be taken from various levels of the small intestine, it could be considered the instrument of choice for peroral jejunal biopsy.
TENTH INTERNATIONAL MEDICAL CONGRESS.Read before the Cambridge Society for Medical Improvement, October 27, 1890.
Authors: AUGUSTUS P. CLARKE
Journal: JAMA (1890)

Your Secretary has requested me to report what proved of interest to me during my recent trip to the Tenth International Medical Congress. In accepting this invitation I am not unaware that much has been written in regard to the Congress, but the interest manifested at Berlin in the healing art was so great, I am sure that any observation or information, though from a point somewhat remotely connected, would not be unacceptable. Before reaching Berlin I was enabled to attend as a delegate the meeting of the British Medical Association which opened on July 29, being one week earlier than usual so as not to interfere with the International meeting. The meeting at Birmingham was instructive and full of interest, and I have no doubt was a fair exponent of the views and practice which prevail in Great Britain. There was, however, a noticeable absence from this meeting
Step-by-step progress toward understanding the hepatitis C virus RNA helicase
Authors: David N. Frick, Hartmut Jaeschke, Kevin Mullen, Darius Moradpour
Journal: Hepatology (2006)

Helicases are a ubiquitous class of enzymes involved in nearly all aspects of DNA and RNA metabolism. Despite recent progress in understanding their mechanism of action, limited resolution has left inaccessible the detailed mechanisms by which these enzymes couple the rearrangement of nucleic acid structures to the binding and hydrolysis of ATP. Observing individual mechanistic cycles of these motor proteins is central to understanding their cellular functions. Here we follow in real time, at a resolution of two base pairs and 20 ms, the RNA translocation and unwinding cycles of a hepatitis C virus helicase (NS3) monomer. NS3 is a representative superfamily-2 helicase essential for viral replication, and therefore a potentially important drug target. We show that the cyclic movement of NS3 is coordinated by ATP in discrete steps of 11 +/- 3 base pairs, and that actual unwinding occurs in rapid smaller substeps of 3.6 +/- 1.3 base pairs, also triggered by ATP binding, indicating that NS3 might move like an inchworm. This ATP-coupling mechanism is likely to be applicable to other non-hexameric helicases involved in many essential cellular functions. The assay developed here should be useful in investigating a broad range of nucleic acid translocation motors.
Clinical and Angiographic Characteristics of Exertion-Related Acute Myocardial Infarction
Authors: Satyendra Giri, Paul D. Thompson, Francis J. Kiernan, Jonathan Clive, Daniel B. Fram, Joseph F. Mitchel, Jeffrey A. Hirst, Raymond G. McKay, David D. Waters
Journal: JAMA (1999)

Context Vigorous physical exertion transiently increases the risk of acute myocardial infarction (MI), but little is known about the clinical characteristics of exertionrelated MI.Objective To compare the clinical and angiographic characteristics of patients who had an exertion-related acute MI vs those who experienced an MI not related to exertion. Design and SettingProspective observational cohort study of patients with an acute MI referred to a tertiary care hospital for primary angioplasty.Patients Of 1048 patients with acute MI, 640 (64 who experienced an exertionrelated MI and 576 who did not) were selected for treatment with primary angioplasty and admitted between August 1995 and November 1998.Main Outcome Measures Clinical characteristics of the patients, including their habitual physical activity (determined by the Framingham Physical Activity Index and the Lipid Research Clinic Physical Activity Questionnaire), angiographic findings during coronary angiography, and the relative risk (RR) of MI during exertion. ResultsPatients who experienced exertion-related MI were more frequently men (86% vs 68%), hyperlipidemic (62% vs 40%), and smokers (59% vs 37%), were more likely to present with ventricular fibrillation (20% vs 11%), Killip classification III or IV heart failure (44% vs 22%), single-vessel disease (50% vs 28%), and a large thrombus in the infarct artery (64% vs 35%) and were more likely to be classified as having very low or low activity (84% vs 66%).The RR of experiencing an MI during exertion was 10.1 times greater than the risk at other times (95% confidence interval [CI], 1.6-65.6),with the highest risk among patients classified as very low active (RR, 30.5; 95% CI, 4.4-209.9)and low active (RR, 20.9; 95% CI, 3.1-142.1). ConclusionThese results show that exertion-related MIs occur in habitually inactive people with multiple cardiac risk factors.These individuals may benefit from modest exercise training and aggressive risk-factor modification before they perform vigorous physical activity.
983-38 Occlusion of Large Atrial Septal Defects with a Centering Buttoned Device: Early Clinical Experience
Authors: Eleftherios B. Sideris, Jung Han Yoon, Chuan-Rong Chen, Maurice Leung, Rajeev Lochan, Anne-Marie Worms, Bernhard Meier, Christian Rey
Journal: Journal of the American College of Cardiology (1995)
Course of patients discharged early after myocardial infarction.
Authors: A D Gelson, P H Carson, H H Tucker, R Phillips, M Clarke, G D Oakley
Journal: BMJ (1976)

Two hundred and seventy-one (76%) out of 358 survivors of infarction were discharged by the eighth hospital day, and 251 (93%) of them survived to six weeks after discharge. Six of the 20 patients who died between discharge and six weeks did so after readmission and 14 died as outpatients. All these patients who died at home had transmural infarction and four had diabetes. In inpatients successful resuscitation occurred mainly within the first 48 hours, with only three successful long-term results from all the patients who suffered arrest later. This suggests that more prolonged inpatient care would not have reduced the late mortality. These figures justify continuing with an early discharge policy for most patients, but coronary care should probably be more prolonged for patients with diabetes.
Portraits from Memory: 25--Professor Robert Cruickshank, CBE (1899-1974)
Authors: J. Howie
Journal: BMJ (1988)

likely to be between 68% and 77%.8This, however, was before the advent of chorionic villus biopsy, with its advantages of first trimester detection of fetal abnormalities.It would probably be wise to plan for a rate of use of at least 80% by the year 2001 and to have facilities in place for some 70 000 prenatal cytogenetic analyses.
Do Lipid-Lowering Agents Provide a Greater Reduction in Cardiovascular Events among Patients with Diabetes?
Authors: Anil K. Gollapudi
Journal: Annals of Internal Medicine (2008)

Letters2 December 2008Do Lipid-Lowering Agents Provide a Greater Reduction in Cardiovascular Events among Patients with Diabetes?Anil K. Gollapudi, MDAnil K. Gollapudi, MDFrom W.G. “Bill” Hefner Veterans Affairs Medical Center, Salisbury, NC 28144.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-11-200812020-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The U.S. Preventive Services Task Force (USPSTF) no longer recommends routine screening for type 2 diabetes mellitus in adults with hyperlipidemia (1). This recommendation seems to have been based, at least in part, on an analysis of the secondary prevention trials, which showed that lipid treatment reduced the incidence of coronary heart disease (CHD) events by about the same relative percentage among those with type 2 diabetes mellitus and those without.Because the incidence of major CHD events is higher in adults with type 2 diabetes mellitus than in those without, one would expect that patients with ...Reference1. U. S. Preventive Services Task Force. Screening for type 2 diabetes mellitus in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2008;148:846-54. [PMID: 18519930] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From W.G. “Bill” Hefner Veterans Affairs Medical Center, Salisbury, NC 28144.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Type 2 Diabetes Mellitus in Adults: U.S. Preventive Services Task Force Recommendation StatementDo Lipid-Lowering Agents Provide a Greater Reduction in Cardiovascular Events among Patients with Diabetes? Ned Calonge and Diana Petitti Metrics 2 December 2008Volume 149, Issue 11Page: 841KeywordsConflicts of interestCoronary heart diseaseDiabetes preventionHyperlipidemiaLipidsType 2 diabetes ePublished: 2 December 2008 Issue Published: 2 December 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Oil-in-Water Emulsion Adjuvant with Influenza Vaccine in Young Children
Authors: Timo Vesikari, Markus Knuf, Peter Wutzler, Aino Karvonen, Dorothee Kieninger-Baum, Heinz-Josef Schmitt, Frank Baehner, Astrid Borkowski, Theodore F. Tsai, Ralf Clemens
Journal: New England Journal of Medicine (2011)

We studied the effect of the adjuvant MF59, an oil-in-water emulsion, on the efficacy of trivalent inactivated influenza vaccine (TIV) in 4707 healthy children 6 to less than 72 months of age who had not previously been vaccinated against influenza. The children were randomly assigned to three study groups, each of which received the assigned vaccines in two doses, 28 days apart, during two consecutive influenza seasons. Two of the groups were given age-appropriate doses of TIV either with or without the MF59 adjuvant, and the third group was given control (noninfluenza) vaccines to assess their absolute and relative efficacy against influenza-like illness, as confirmed by means of polymerase-chain-reaction (PCR) assay.
Awareness of symptoms could eliminate 5600 late cancer diagnoses in England each year
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Age, sex, and income as well as the type of cancer influence the stage at which patients’ cancer is diagnosed, a study has found.

Eliminating these demographic inequalities would help improve the chances of a cure for up to 5600 patients in England with seven common cancers each year, the researchers have estimated.

For the study, published in the Annals of Oncology , researchers from the University of Cambridge and the Eastern Cancer Registration and Information Centre examined data on the stage at diagnosis of nearly 100 000 patients with any of 10 different cancers, …
Staphylococcal Bacteremia and Altered Host Resistance
Authors: LEIGHTON E. CLUFF
Journal: Annals of Internal Medicine (1968)

The demographic, clinical, pathogenetic, and microbiologic features of 185 consecutive patients with staphylococcal bacteremia recognized at Johns Hopkins Hospital from 1952 to 1965 are reviewed to isolate features responsible for and characteristic of staphylococcal sepsis. Bacteremia was commonest in the very young and very old. The overall mortality was 42%. A source of sepsis was usually found, with skin trauma and postoperative wound infection the commonest causes. Intravenous cutdowns and plastic catheters were significant sites for the origin of staphylococcal sepsis. Seventy-five percent of the patients studied had significant associated illnesses accompanying the bacteremia that adversely influenced the outcome. Arteriosclerotic cardiovascular disease, diabetes mellitus, and lymphoma-leukemia were present in many patients singly or in combination, and the role of associated illness in altering the host response to this infection is discussed. Twenty-five patients had Staphylococcus albus bacteremia, and although the characteristics of infection did not differ from S. aureus bacteremia, the mortality rate was 28%. Most staphylococci were phage typed. There were no strains associated with increased mortality, specific origin of sepsis, or type of associated illness.