Humoral Hypercalcemia Associated with a Uterine Fibroid
Authors: Keyvan Ravakhah
Journal: Annals of Internal Medicine (1999)

Letters20 April 1999Humoral Hypercalcemia Associated with a Uterine FibroidKeyvan Ravakhah, MD, Alina Gover, MD, and Beejadi N. Mukunda, MDKeyvan Ravakhah, MDMeridia Huron Hospital; Cleveland, OH 44112 (Ravakhah)Meridia Huron Hospital; Cleveland, OH 44112 (Gover)Meridia Huron Hospital; Cleveland, OH 44112 (Mukunda), Alina Gover, MDMeridia Huron Hospital; Cleveland, OH 44112 (Ravakhah)Meridia Huron Hospital; Cleveland, OH 44112 (Gover)Meridia Huron Hospital; Cleveland, OH 44112 (Mukunda), and Beejadi N. Mukunda, MDMeridia Huron Hospital; Cleveland, OH 44112 (Ravakhah)Meridia Huron Hospital; Cleveland, OH 44112 (Gover)Meridia Huron Hospital; Cleveland, OH 44112 (Mukunda)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-8-199904200-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Humoral hypercalcemia of benignancy is a recently described syndrome characterized by hypercalcemia induced by parathyroid hormone-related protein (PTHrP) produced by a benign tumor (1). Four cases have been reported, one each caused by ovarian dermoid cysts, intestinal leiomyoma, mammary hyperplasia, and pheochromocytoma (1-4). Uterine fibroids show relative overexpression of the PTHrP gene (5).A 73-year-old woman who had had an asymptomatic uterine fibroid for 38 years presented with weakness of 2 weeks' duration. She was lethargic and dehydrated. Her abdomen was distended by a large, firm mass. The serum calcium level was 16.7 mg/dL (normal, 8.4 to ...References1. Knecht TP, Behling CA, Burton DW, Glass CK, Deftos LJ. The humoral hypercalcemia of benignancy. A newly appreciated syndrome. Am J Clin Pathol. 1996;105:487-92. CrossrefMedlineGoogle Scholar2. Rathaus M, Bernheim JL, Griffel B, Bernheim J, Taragan R, Gutman A. Leiomyoma of the small bowel with hypercalcemia: presence of a substance with parathormone activity. Nouv Pressue Med. 1978;8:3245-6. Google Scholar3. Khosla S, van Heerden JA, Gharib H, Jackson IT, Danks J, Hayman JA, et al . Parathyroid hormone-related protein and hypercalcemia secondary to massive mammary hyperplasia [Letter]. N Engl J Med. 1990;322:1157. CrossrefMedlineGoogle Scholar4. Kimura S, Nishimura Y, Yamaguchi K, Nagasaki K, Shimada K, Uchida H. A case of pheochromocytoma producing parathyroid hormone-related protein and presenting with hypercalcemia. J Clin Endocrinol Metab. 1990;70:1559-63. CrossrefMedlineGoogle Scholar5. Weir EC, Goad DL, Daifotis AG, Burtis WJ, Dreyer BE, Nowak RA. Relative overexpression of the parathyroid hormone-related protein gene in human leiomyomas. J Clin Endocrinol Metab. 1994;78:784-9. MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Meridia Huron Hospital; Cleveland, OH 44112 (Ravakhah)Meridia Huron Hospital; Cleveland, OH 44112 (Gover)Meridia Huron Hospital; Cleveland, OH 44112 (Mukunda) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEctopic Prolactin Secretion From a Uterine LeiomyomaGynecological neoplasms associated with paraneoplastic hypercalcemiaSuspected Hypercalcemia of Benignancy Associated with Canine Vaginal LeiomyomaBenign Uterine DiseasesUnusual presentation of uterine leiomyomaHypercalcemia Due to PTHrPOverview of Latest Evidence on Uterine FibroidsBenign Uterine DiseasesPTHrP-associated hypercalcemia of pregnancy resolved after delivery: a case reportΝον-Islet Cell Tumor Hypoglycemia Associated With Uterine LeiomyomataParathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephromaBenign Uterine DisordersThyroid Follicular Adenoma Producing Parathyroid Hormone-related Protein with a Normal Serum Calcium LevelHumoral Hypercalcemia of Benignancy Secondary to Parathyroid Hormone-Related Protein Secreting Uterine LeiomyomaHypercalcemia during Pregnancy, Puerperium, and Lactation: Review and a Case Report of Hypercalcemic Crisis after Delivery Due to Excessive Production of PTH-related Protein (PTHrP) without Malignancy (Humoral Hypercalcemia of Pregnancy)Giant pilomatricoma associated with hypercalcaemia and elevated levels of parathyroid hormone-related proteinHypercalcemia associated with a uterine leiomyoma: a case report and review of the literatureA Parathyroid Hormone–Related Protein–Secreting Metastatic Epithelioid LeiomyosarcomaTreatment of uterine fibroids 20 April 1999Volume 130, Issue 8Page: 702KeywordsCalciumHypercalcemiaParathyroid hormoneProteinsSerum albuminSurgeryThoraxTotal abdominal hysterectomyUrineVitamin D Issue Published: 20 April 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...