tbuckley/cabot-search huggingface dataset:
Cortical Vein Air Emboli With Gyriform Infarcts
Authors: Daniel Lai, Tudor G. Jovin, Ashutosh P. Jadhav
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Relationship Between the Ballistocardiogram and the Movement of Blood from the Left Ventricle in the Dog
Authors: P. J. Winter, D. C. Deuchar, M. I. M. Noble, D. Trenchard, A. Guz
Journal: Cardiovascular Research (1967)

This study was undertaken to investigate the possible relation between myocardial contractility and the pattern of the head-foot force ballistocardiogram. Dogs previously prepared with implanted aortic flowmeters were studied on a specially constructed ballistocardiograph. A direct relationship was found between the amplitude of the early systolic waves of the ballistocardiogram and myocardial contractility as measured by the peak acceleration of blood from the left ventricle.
Eye-movement control in reading: Models and predictions
Authors: Eyal M. Reingold
Journal: Behavioral and Brain Sciences (2003)

It is argued here that a critical prediction of the E-Z Reader model is that experimental manipulations that disrupt early encoding of visual and orthographic features of the fixated word without affecting subsequent lexical processing should influence the processing difficulty of the fixated word without producing any processing effect on the next word. This prediction is explained and illustrated.
Abstract 2513: Arsenic trioxide induces depolymerization of microtubules in an acute promyelocytic leukemia cell line
Authors: Young Joo Min, Seung Joo Cha, Hee-Soon Lee, Jin Ho Baek, Min Jae Park, Hawk Kim, Jae-Hoo Park, Keon Uk Park, Jong-Ho Won
Journal: Cancer Research (2010)

Abstract Arsenic trioxide (ATO) treatment has been used in recent decades to achieve clinical remission in patients with acute promyelocytic leukemia (APL). The biological basis for ATO treatment has been explained as being mediated through anti-proliferation, anti-angiogenesis, and apoptosis in both APL and solid tumor cells. Arsenic trioxide has been shown to affect microtubules such that dysfunction of the cellular cytoskeleton is induced, which ultimately leads to cell death. In this study, we reported that ATO disrupts tubulin assembly and results in microtubule dysfunction, inducing cell death in an APL cell line. ATO markedly enhanced the depolymerization of microtubules. Analysis of posttranslational modifications of microtubules also revealed that ATO decreased modified forms of the polymerized tubulin portion in adose-dependent manner. Immunocytochemical investigation showed that ATO changed the cellular microtubule network and inhibited the formation of polymerized microtubules. These alterations in microtubules suggest that ATO increases the depolymerized form of tubulin in the cells, potentially through its effect on the attenuation of spindle dynamics. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2513.
Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease
Authors: Dan Xia, Hirotaka Watanabe, Bei Wu, Sang Hun Lee, Yan Li, Evgeny Tsvetkov, Vadim Y. Bolshakov, Jie Shen, Raymond J. Kelleher
Journal: Neuron (2015)
A POSITION OF MAXIMUM COMFORT IN CASES OF RECTAL DISEASE
Authors: J. F. Montague
Journal: JAMA (1925)

Whenever it becomes necessary to confine a patient suffering from rectal disease to bed, it will be of comfort to the patient and of value to the physician to know that there<i>is</i>a posture which will afford maximum ease. The patient, lying in bed in the ordinary position with a pillow at the head, is theoretically lying level, yet he actually lies, because of the sagging of the bed, in such a manner that the anal and rectal region are considerably lower than the rest of the body. It can be readily seen that this dependent position by gravity alone does much to increase the local congestion already in progress. This induces an extensive edema of the perianal skin and anal canal, which adds considerably to the distress of the patient. Furthermore, in the ordinary prone position, the distribution of the weight of the viscera of the pelvis and
Biology of Colorectal Cancer Liver Metastasis
Authors: Chul Ho Cho, Robert Radinsky
Journal: Liver Cancer (1998)

Metastasis—the spread of malignant tumor cells from a primary neoplasm to distant parts of the body where they multiply to form new growths—is a major cause of death from cancer. The treatment of metastatic cancer poses a major problem to clinical oncologists because the presence of multiple metastases makes complete eradication by surgery, irradiation, or drugs nearly impossible. For most tumors, including colorectal carcinoma, the presence of liver metastasis renders the patient essentially incurable. A better understanding of the biology of liver metastases and the molecular events leading to the metastatic phenotype is essential if new and innovative therapeutic approaches are to be developed to treat this disease.
Treatment of the Minimally Slipped Capital Femoral Epiphysis
Authors: Lawrence C. Mozan
Journal: JAMA (1968)

The three most widely accepted methods for treatment of minimally slipped capital femoral epiphysis were compared with respect to efficacy, degree of technical difficulty, and subsequent complications. Findings and conclusions are based upon a series of cases from the orthopedic department of the Chicago Wesley Memorial Hospital and cases reported in the literature over the past 20 years.
Novel Biochemical Diagnostic Method for Aortic Dissection
Authors: Toru Suzuki, Hirohisa Katoh, Masafumi Watanabe, Masahiko Kurabayashi, Katsuhiko Hiramori, Shingo Hori, Masakiyo Nobuyoshi, Hiromitsu Tanaka, Kazuhisa Kodama, Hikaru Sato, Shin Suzuki, Yasuhiro Tsuchio, Yoshio Yazaki, Ryozo Nagai
Journal: Circulation (1996)

Aortic dissection is one of the most common aortic catastrophes. Although newer diagnostic methods as exemplified by image diagnostic techniques have greatly improved the diagnosis of aortic dissection, the diagnosis is still frequently missed today because the signs and symptoms of the disease are at times obscure. A reliable biochemical diagnostic method for aortic dissection would be beneficial.A novel biochemical diagnostic method for diagnosis of aortic dissection was developed that uses an immunoassay of monoclonal antibodies to smooth muscle myosin heavy chain. A prospective study was conducted to ascertain the usefulness of the method in the diagnosis of aortic dissection. Twenty-seven patients with aortic dissection admitted within the first 24 hours after onset were enrolled. Serial assay of serum smooth muscle myosin heavy chain showed significant elevations within the first 24 hours after onset of aortic dissection, with levels exceeding 10 ng/mL, with subsequent rapid reductions. The sensitivity of the assay within the first 12 hours was 90% with a specificity of 97%. Analysis of 65 patients with acute myocardial infarction showed that the method could accurately differentiate myocardial infarction from aortic dissection.The immunoassay of serum smooth muscle myosin heavy chain is a rapid and reliable biochemical method in the diagnosis of aortic dissection. The potential use of the method in clinical medicine is promising.
As Long as Life: The Memoirs of a Frontier Woman Doctor
Authors: Jane M. Orient
Journal: JAMA (1995)

Things were different in New York City in Mary Rowland's day. When Dr Rowland "talked a bit smart" to a policeman warning her off the horse trail in Central Park, he said he had to scold someone occasionally to keep from going crazy. Dr Rowland's response to an episode of probable sexual harassment was to say, "Mister, you get going or I'll shove you in the gutter." The man's reply: "Oh, excuse me, madam, I've made a mistake." The practice of medicine was vastly different too. Doctors had to know how to extract teeth and how to use the reins to control a runaway team of horses. Medical payment records, kept in pen and ink, had entries such as "by potatoes, 17.05." Medical science sometimes had little to offer, yet ingenuity and common sense accomplished much. We might even consider reviving a long-forgotten idea (quarantine) used to contain epidemics such
Toxic Psychosis Following Nondialytic Therapy of Chronic Renal Failure
Authors: Stephen A. Ockner
Journal: JAMA (1971)

The clinical status of two patients with chronic renal failure had deteriorated because of protracted vomiting. Intravenous repletion of fluids and electrolytes produced a marked improvement in uremic symptoms and azotemia. However, within two and four days, respectively, of this improvement, transient toxic psychosis occurred. The pathogenesis of this psychosis was felt to be similar to that responsible for the striking central nervous system symptoms which frequently occur in association with dailysis or spontaneously during the diuretic phase of acute renal failure.
Study of Chromosomes in the Newborn after Ultrasonic Fetal Heart Monitoring in Labour
Authors: M. Lucas, M. Mullarkey, U. Abdulla
Journal: BMJ (1972)

The effect of continuous-wave ultrasound on the chromosomes of newborn infants has been investigated. Twenty-four women were studied during labour. The fetal heart was monitored by a Sonicaid FM2 monitor applied to the abdomen, and continuous monitoring undertaken for intervals varying from 1 hour 5 minutes to 9 hours 25 minutes. There was no increase in the number of chromosome aberrations in cultures of blood taken from the insonated babies when compared with controls.
Education of Residents
Authors: Leonard S. Stein
Journal: JAMA (1981)

To the Editor.—  The rigorous research design and careful data collection and interpretation used by Pinkerton et al (1980;244:2183) admirably replicate previous reports that mere transmission of information in episodic learning rarely changes clinical behavior. 1 Their interpretations, however, do not fully explore the medical education issues they address.  The authors describe an educational intervention as consisting only of a videotape. In fact, the full learning activity included at least six steps: (1) chart audit to identify learning need, (2) transmission of relevant information via videotape, (3) pretesting and post-testing to assess gain of factual information, (4) further chart audit to see if information gained was being translated into clinical performance, (5) feedback to learners when chart audit showed no adoption of the fluoridation protocol, and (6) personal supervision of each resident. The result was a successful learning experience: 90.7% of pediatric patients assigned to these residents were ingesting the
Hepatitis C virus load and survival among injection drug users in the United States
Authors: Michie Hisada, Nilanjan Chatterjee, Zeynep Kalaylioglu, Robert J. Battjes, James J. Goedert
Journal: Hepatology (2005)

Persons chronically infected with hepatitis C virus (HCV), some of whom may be coinfected with HIV and human T-lymphotropic virus type II (HTLV-II), are at high risk for end-stage liver disease (ESLD). We evaluated whether ESLD death was associated with premorbid HCV RNA level or specific HCV protein antibodies among persons with or without HIV/HTLV-II coinfection in a cohort of 6,570 injection drug users who enrolled in 9 US cities between 1987 and 1991. We compared 84 ESLD descendents and 305 randomly selected cohort participants with detectable HCV RNA, stratified by sex, race, HIV, and HTLV-II strata. Relative hazard (RH) of ESLD death was derived from the proportional hazard model. Risk of ESLD death was unrelated to the intensity of antibodies against the HCV c-22(p), c-33(p), c-100(p), and NS5 proteins, individually or combined, but it increased with HCV RNA level (RHadj= 2.26 per log10 IU/mL, 95% CI: 1.45-5.92). The association between HCV RNA level and ESLD death remained significant after adjustment for alcohol consumption (RHadj= 2.57 per log10 IU/mL, 95% CI: 1.50-8.10). Deaths from AIDS (n = 45) and other causes (n = 43) were unrelated to HCV RNA (RHadj= 1.14 and 1.29 per log10 IU/mL, respectively). HIV infection was not associated with ESLD risk in multivariate analyses adjusted for HCV RNA. Men had an increased risk of ESLD death in unadjusted analyses (RH = 1.92, 95% CI: 1.15-3.56) but not in multivariate analysis (RHadj= 0.98, 95% CI: 0.48-2.88). Non-black patients were at increased risk for ESLD death (RHadj= 2.76, 95% CI: 1.49-10.09). In conclusion, HCV RNA level is a predictor of ESLD death among persons with chronic HCV infection. (HEPATOLOGY 2005.)
Incidental Rectus Abdominis Muscle Visualization during Bone Scanning
Authors: HIRAM RIVERA-LUNA, ETHAN J. SPIEGLER
Journal: Clinical Nuclear Medicine (1991)

A 31-year-old man was referred for a bone scan as part of an evaluation of a 2-month history of left thoracic cage pain. Four days before the examination, he competed with some friends at sit-ups and after that had noted soreness of his anterior abdomen. A bone scan was performed following the intravenous administration of 20 mCi (740 MBq) of Tc-99m MDP and revealed noticeable extraosseous accumulation of the tracer in the rectus abdominis muscle bilaterally. No abnormality was found in the left thorax at the site of chest pain.
Lipopolysaccharide-induced hepatic injury is enhanced by polychlorinated biphenyls.
Authors: A P Brown, A E Schultze, W L Holdan, J P Buchweitz, R A Roth, P E Ganey
Journal: Environmental Health Perspectives (1996)

After intravenous administration of bacterial lipopolysaccharide (LPS) to rats, polymorphonuclear neutrophils (PMNs) rapidly accumulate in the liver, and midzonal hepatic necrosis is prominent by 6 hr. PMNs are required for the development of hepatic injury in rats. Certain polychlorinated biphenyls (PCBs) can activate PMNs, resulting in production of superoxide anion (O2-.) and release of cytolytic factors from granules. This raises the possibility that PCB exposure might enhance PMN-mediated tissue injury, such as LPS-induced hepatotoxicity. We treated female Sprague-Dawley rats with a minimally toxic dose of LPS in saline (2 mg/kg, intravenous) and 90 min later exposed them to Aroclor 1248 (50 mg/kg, intraperitoneal), a mixture of PCBs. The animals were killed 6 hr after LPS administration, and hepatic injury was assessed. Neither LPS nor Aroclor 1248 alone produced liver injury. Co-treatment with LPS and Aroclor 1248 resulted in pronounced liver injury as demonstrated from increased activities of alanine aminotransferase and isocitrate dehydrogenase in plasma. Histological evaluation indicated increased severity of hepatic necrosis in rats receiving both LPS and Aroclor 1248. Hepatic accumulation of PMNs, normally observed after LPS, was not altered by co-exposure to PCBs. Aroclor 1248 stimulated rat PMNs in vitro to produce O2-. and to degranulate. In addition, PMN-mediated cytotoxicity to isolated rat hepatocytes in culture was increased upon addition of Aroclor 1248. PCBs activate PMNs in vitro and increase PMN-dependent hepatocellular damage in vitro and after LPS treatment in vivo. PCBs may act in vivo as an additional inflammatory stimulus to activate PMNs to become cytotoxic, resulting in increased tissue injury.
Identification of somatostatin receptors in human cirrhosis and hepatocellular carcinoma
Authors: Hendrik Reynaert, Krista Rombouts, Karine Hellemans, Alain Vandermonde, J.M. Lazou, Daniel Urbain, Paulette Bioulac-Sage, Jean Rosenbaum, Albert Geerts
Journal: Journal of Hepatology (2002)
Left ventricular function at 3 months after successful thrombolysis. Impact of reocclusion without reinfarction on ejection fraction, regional function, and remodeling.
Authors: A Meijer, F W Verheugt, M J van Eenige, C J Werter
Journal: Circulation (1994)

BACKGROUND After successful thrombolysis for acute myocardial infarction, reocclusion is observed in about 30% of patients after 3 months and usually occurs without reinfarction. We studied the impact of reocclusion without reinfarction on global and regional left ventricular function and on remodeling during that period. METHODS AND RESULTS The patients for this analysis constituted a subset of those enrolled in the APRICOT-trial, which was designed to study the efficacy of antithrombotics on the prevention of reocclusion. Patients were selected who had a left anterior descending- or right coronary artery-related myocardial infarction, had an angiographically patent infarct-related vessel when studied &lt; 48 hours after intravenous thrombolysis, and underwent repeat cardiac catheterization at 3 months. Paired contrast ventriculograms of quality sufficient to analyze regional wall motion, global ejection fraction, and ventricular volumes were analyzed in 129 patients. Enzymatic infarct size and baseline left ventricular function as well as other baseline characteristics were similar in patients with (n = 34) and without (n = 95) reocclusion. Ejection fraction improved in anterior infarction without reocclusion from 47 +/- 10% to 54 +/- 13% (P = .0001) but not with reocclusion (baseline, 48 +/- 13%; 3 months, 48 +/- 16%). No improvement was seen in inferior infarction with or without reocclusion. Persistent patency allowed preservation of end-systolic volume index (ESVI) at 3 months (37 +/- 14 mL/m2) to baseline level (38 +/- 13 mL/m2), with a better chance for improvement of &gt; 10 mL/m2 without reocclusion in those with baseline values &gt; 40 mL/m2. After reocclusion, in contrast, ESVI increased from 37 +/- 14 to 43 +/- 20 mL/m2 (P = .08). Comparable mean changes of ESVI in response to persistent patency or reocclusion were seen in anterior versus inferior infarction. Recovery of infarct zone contractility was impaired by reocclusion, both in terms of abnormality of segment shortening and expressed in the number of segments showing abnormal wall motion. In anterior but not in inferior infarction, infarct zone contractility was better with good collaterals to the reoccluded artery compared with poor collaterals. CONCLUSIONS After successful thrombolysis for acute myocardial infarction, reocclusion without reinfarction withholds salvaged myocardium from regaining contractility. This has deleterious consequences for regional and global left ventricular function and for remodeling. To further optimize prognosis in patients after thrombolysis, future research should focus on the prevention of reocclusion and should evaluate revascularization therapy in patients with reocclusion.
Body Mass Index, Surgery, and Risk of Venous Thromboembolism in Middle-Aged Women
Authors: Lianne Parkin, Siân Sweetland, Angela Balkwill, Jane Green, Gillian Reeves, Valerie Beral
Journal: Circulation (2012)

Background— Obesity and surgery are known risk factors for venous thromboembolism (VTE), but there is limited information about the independent effects of obesity on the incidence of postoperative VTE. We linked questionnaire data from the Million Women Study with hospital admission and death records to examine the risk of VTE in relation to body mass index (BMI) both in the absence of surgery and in the first 12 weeks following an operation. Methods and Results— Overall, 1 170 495 women (mean age, 56.1 years) recruited in 1996 to 2001 through the National Health Service Breast Screening Programme in England and Scotland were followed for an average of 6 years, during which time 6438 were admitted to hospital or died of VTE. The adjusted relative risks of VTE increased progressively with increasing BMI and women with a BMI ≥35 kg/m 2 were 3–4 times as likely to develop VTE as those with a BMI 22.5 to 24.9 (relative risk 3.45 [95% CI 3.09–3.86]). Overweight and obese women were more likely than lean women to be admitted for surgery and also to develop postoperative VTE. During a 12-week period without surgery, the incidence rates of VTE per 1000 women with a BMI &lt;25 and ≥25 were 0.10 (0.09–0.10) and 0.19 (0.18–0.20); the corresponding rates in the 12 weeks following day and inpatient surgery were, respectively, about 4 and 40 times higher. Conclusions— VTE risk increases with increasing BMI and the associated excess risk is much greater after surgery than without surgery.
Morphometric analysis of blood vessels in synovial membranes obtained from clinically affected and unaffected knee joints of patients with rheumatoid arthritis.
Authors: O FitzGerald, M Soden, G Yanni, R Robinson, B Bresnihan
Journal: Annals of the Rheumatic Diseases (1991)

Synovial tissues from inflamed and noninflamed knee joints of 13 patients with untreated rheumatoid arthritis were examined for vascular proliferation and morphological alteration of endothelial cells. Perivascular mononuclear cell infiltration and increased thickness of the synovial lining layer were noted in tissues from inflamed and noninflamed joints of patients with rheumatoid arthritis; vascular proliferation and morphological alteration of endothelial cells to resemble high endothelial venules were seen only in tissues from inflamed joints of patients with rheumatoid arthritis. These observations suggest that the migration of mononuclear cells from the peripheral blood to the perivascular areas and lining layer occurs before vascular proliferation and morphological alteration of endothelial cells.
HIV-1–infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase
Authors: Andrew N. Harman, Marianne Kraus, Chris R. Bye, Karen Byth, Stuart G. Turville, Owen Tang, Sarah K. Mercier, Najla Nasr, Josh L. Stern, Barry Slobedman, Christoph Driessen, Anthony L. Cunningham
Journal: Blood (2009)
Verapamil-induced secondary erythermalgia
Authors: J.P.H. DRENTH, J.J. MICHIELS, T. JOOST, V.D. VUZEVSKI
Journal: British Journal of Dermatology (1992)

Summary A 59-year-old man developed red, swollen and warm feet accompanied by intermittent burning pain during treatment for cardiac failure and arrhythmias with several drugs including verapamil. The condition gradually worsened until there was persistent disabling burning pain and severe erythema and swelling of the feet. Aspirin and other analgesics were ineffective in relieving the discomfort. Histopathology of punch biopsies showed a mild perivascular mononuclear infiltrate and moderate perivascular oedema. Within 2 weeks of stopping verapamil the burning pain, erythema, and swelling of the feet had resolved. The clinical features and subsequent course are consistent with a diagnosis of erythermalgia secondary to verapamil.