Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding
Authors: Mohammed S. Khuroo, Mehnaaz S. Khuroo
Journal: Annals of Internal Medicine (2004)

Letters6 July 2004Managing Patients with Nonvariceal Upper Gastrointestinal BleedingMohammed S. Khuroo, MD, DM, DRCP(Edin) and Mehnaaz S. Khuroo, MDMohammed S. Khuroo, MD, DM, DRCP(Edin)From King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia; and Sri-Ramachandra Medical College and Research Institute, Porur Chennai, India.Search for more papers by this author and Mehnaaz S. Khuroo, MDFrom King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia; and Sri-Ramachandra Medical College and Research Institute, Porur Chennai, India.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-1-200407060-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The members of the Nonvariceal Upper GI Bleeding Consensus Conference Group recommended an intravenous bolus followed by continuous infusion of proton-pump inhibitors to decrease rebleeding in patients who have undergone successful endoscopic therapy (1). The group commented on the excellent safety profile of proton-pump inhibitors.We conducted a meta-analysis of randomized, controlled trials that compared proton-pump inhibitors with placebo or H2-receptor antagonists in patients with upper gastrointestinal bleeding (2). Of the 175 articles screened, 26 controlled trials involving 4670 patients were analyzed. Five outcome measures were used to assess the effects of proton-pump inhibitors in the selected ...References1. Barkun A, Bardou M, Marshall JK. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2003;139:843-57. [PMID: 14623622] LinkGoogle Scholar2. Khuroo MS, Khuroo MS, Farhat KLC, Kagevi IE. Treatment with proton-pump inhibitors in acute nonvariceal upper gastrointestinal bleeding: a meta-analysis. J Gastroenterol Hepatol. [In press]. Google Scholar3. Hasselgren G, Lind T, Lundell L, Aadland E, Efskind P, Falk A, et al . Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Results of a placebo-controlled multicenter study. Scand J Gastroenterol. 1997;32:328-33. [PMID: 9140154] CrossrefMedlineGoogle Scholar4. Schaffalitzky de Muckadell OB, Havelund T, Harling H, Boesby S, Snel P, Vreeburg EM, et al . Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers. Randomized double-blind placebo-controlled multicentre study. Scand J Gastroenterol. 1997;32:320-7. [PMID: 9140153] CrossrefMedlineGoogle Scholar5. McCabe RD, Young DB. Evidence of a K(+)-H(+)-ATPase in vascular smooth muscle cells. Am J Physiol. 1992;262:H1955-8. [PMID: 1320341] MedlineGoogle Scholar6. Christensen PB, Albertsen KE, Jensen P. Renal failure after omeprazole [Letter]. Lancet. 1993;341:55. [PMID: 8093302] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Mohammed S. Khuroo, MD, DM, DRCP(Edin); Mehnaaz S. Khuroo, MDAffiliations: From King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia; and Sri-Ramachandra Medical College and Research Institute, Porur Chennai, India. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoConsensus Recommendations for Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding Alan Barkun , Marc Bardou , John K. Marshall , and Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding Alan Barkun , Marc Bardou , and John K. Marshall Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding Angelo Andriulli , Vito Annese , and Gioacchino Leandro Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding Kenneth M. Kessler Metrics 6 July 2004Volume 141, Issue 1Page: 79-80KeywordsDeath ratesHemorrhageMortalityOdds ratioSafetySafety studiesSmooth musclesSurgeryUlcersVasoconstriction ePublished: 6 July 2004 Issue Published: 6 July 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...