tbuckley/cabot-search huggingface dataset:
Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis
Authors: Wan-Ting Chen, Chun-Chih Tseng, Kyle Pfaffenbach, Gary Kanel, Biquan Luo, Bangyan L. Stiles, Amy S. Lee
Journal: Hepatology (2013)

Liver cancer is one of the most common solid tumors, with poor prognosis and high mortality. Mutation or deletion of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is strongly correlated with human liver cancer. Glucose-regulated protein 94 (GRP94) is a major endoplasmic reticulum (ER) chaperone protein, but its in vivo function is still emerging. To study the role of GRP94 in maintaining liver homeostasis and tumor development, we created two liver-specific knockout mouse models with the deletion of Grp94 alone, or in combination with Pten , using the albumin-cre system. We demonstrated that while deletion of GRP94 in the liver led to hyperproliferation of liver progenitor cells, deletion of both GRP94 and PTEN accelerated development of liver tumors, including both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), suggestive of progenitor cell origin. Furthermore, at the premalignant stage we observed disturbance of cell adhesion proteins and minor liver injury. When GRP94 was deleted in PTEN-null livers, ERK was selectively activated. Conclusion : GRP94 is a novel regulator of cell adhesion, liver homeostasis, and tumorigenesis. (HEPATOLOGY 2014;59:947–957)
Molecular Subtype Profile Reveals Therapy Predictive Power.
Authors: F. de Snoo, O. Krijgsman, P. Roepman, R. Bender, A. Glas
Journal: Cancer Research (2009)

Abstract BackgroundClassification of breast cancers into molecular subtypes may be important for accurate selection of therapy for patients. Here we report the respective chemotherapy responsiveness of the molecular subtypes profile defined Luminal, ERBB2 and Basal type.MethodsAn 80-gene subtype profile was developed based on a series of 200 samples with concordant ER, PR and Her2 receptor IHC and single gene readout status. Previously we reported the excellent validation of the profile classification using 784 samples. Here we report a second in silico validation consisting of 133 samples (Hess et al, JCO, 2006) which tested the profile as a predictor of pathological Complete Response (pCR) in these patients treated with T/FAC neoadjuvant chemotherapy.ResultsIn the 133 publicly available samples the profile classified 62% (82) as Luminal-type, 18% (24) as ERBB2-type and 20% (27) as Basal-type. These results were consistent with percentages found in the training and validation cohorts (n=1079; 295 training and 784 validation samples); 66% (712) Luminal-type, 18% (194) as ERBB2-type and 16% (173) Basal-type. Chemotherapy response was measured by pathological Complete Response (pCR) at the time of surgery In the Luminal-type subgroup 9% (7) of patients showed pCR, in the ERBB2-type subgroup 50% (12) of patients had a pCR and in the Basal-type subgroup 56% (15) of patients had a pCR.ConclusionsThe developed multi-gene profile can classify breast cancer tumors into Luminal-, ERBB2- and Basal-type subgroups. Within the subgroups, a significant difference in chemotherapy response, as measured by pCR, is observed. Implementation of this knowledge may improve the clinical management of breast cancer patients, by enabling the physician to decide who is most likely to benefit from chemotherapy or endocrine therapy prior to surgery. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6131.
Pneumocystis pneumonia in HIV antibody positive patients.
Authors: R Rodriguez-Roisin, J A Barbera, J Roca
Journal: Thorax (1994)

Pneumocystis pneumonia in HIV antibody positive patientsThe impression was given by DrJ Sauleda and colleagues (February 1994;49:112-5) that the significant decrease in Sao, observed in pa- tients with PNeu,nwoystis canonii pneumonia
Beyond “pardonable errors by subjects and unpardonable ones by psychologists”
Authors: X. T. Wang
Journal: Behavioral and Brain Sciences (2000)

Violations and biases relative to normative principles of rationality tend to occur when the structure of task environments is novel or the decision goals are in conflict. The two blades of bounded rationality, the structure of task environments and the computational capacities of the actor, can sharpen the conceptual distinctions between the sources of the normative and descriptive gap.
THE PREVENTION OF PELVIC DISEASE BEFORE AND DURING PUBERTY.
Authors: W. H. HUMISTON
Journal: JAMA (1902)

So intimate is the association between the normal functional life and soundness of mind and body in the young woman, that my part of this discussion resolves itself largely into the subject of general hygiene. However interesting the résumé of authorities upon proper diet, dress, posture and exercise (both mental and physical) might prove, yet I shall consider but a few points of more specific character. The first question which one naturally asks is: "What are the pathologic conditions of the uterus and its adnexa whose causative factors may be traced to the period leading up to and beyond puberty?" 1, retroversions and retroflexions of the uterus; 2, endometritis; 3, metritis; 4, sclerotic and cystic degeneration of the ovaries. <h3>1. Displacements.</h3> —Goodell has related a number of cases of sudden misplacements of the uterus caused by the making of a misstep, or by jumping from the high old-fashioned stage coaches
Sarcoidosis mimicking cholangiocarcinoma
Authors: O. Nehls, H. Hass, P. Weber, S. Dette, U. Lauer, H.-P. Schlemmer, M. Oehlert, M. Gregor, B. Klump
Journal: Endoscopy (2006)

A 68-year-old man was admitted to hospital in May 2002 because of weight loss of 12 kg within 1 year. Blood tests showed elevated aspartate aminotransferase 224 U/l (normal range < 22), alanine aminotransferase 365 U/l (normal range < 24), alkaline phosphatase 513 U/l (normal range 60 - 170), γ-glutamyl transpeptidase 1.031 U/l (normal range < 28), total serum bilirubin 2.2 mg/dl (normal range < 1.0), direct serum bilirubin 1.8 mg/dl (normal range < 1), and serum angiotensin-converting enzyme 21 U/l (normal range < 20). There were no abnormalities regarding viral hepatitis markers, antibody profiles, or the CA 19 - 9 value. The patient had been diagnosed with sarcoidosis 5 years previously.
Acquired Dysgammaglobulinemia
Authors: Fred S. Rosen, James A. Bougas
Journal: New England Journal of Medicine (1963)

THE immune globulins can be separated into three classes on the basis of their electrophoretic and ultracentrifugal properties.1 The largest group is the gamma2 globulin, which sediments in the ultracentrifuge with a sedimentation constant of 7 Svedbergs (7S). Two minor components of the immune globulins both have gamma1-globulin mobility but are distinguished by the fact that they have either 7S or 19S sedimentation constants. In congenital and acquired agammaglobulinemia all three classes of immune globulin are absent from the serum.2 A number of male children have been described in whose serum virtually no 7S gamma globulin is . . .
Hepatitis C virus infection in medical personnel after needlestick accident
Authors: Takehiro Mitsui, Keiko Iwano, Kazuo Masuko, Chikao Yamazaki, Hiroaki Okamoto, Fumio Tsuda, Takeshi Tanaka, Shunji Mishiro
Journal: Hepatology (1992)

Hepatitis C virus infections in medical personnel after needlestick accidents have been documented generally by detection of seroconversion to a hepatitis C virus nonstructural region antigen, c100-3 (a marker of infection). We tested for hepatitis C virus core-derived antibodies and genomic RNA in addition to c100-3 antibody in 159 cases of needlestick exposure that did not involve patients positive for HBsAg. Of these we found 68 cases with index patients positive for both hepatitis C virus RNA and antibodies and members negative for antibodies to HCV core or c100-3 before the needlestick accidents. Seven of these medical personnel became infected with hepatitis C virus after the accidents. Their hepatitis was generally subclinical or self-limited and transient, except for one patient in whom liver enzyme elevation persisted along with the antibodies. In our study, the risk of hepatitis C virus transmission from a single needlestick accident with hepatitis C virus RNA-positive blood was 10%, considerably higher than the 4% estimated in a previous study. We found that donor blood with antibody to an hepatitis C virus core-derived peptide with enzyme-linked immunosorbent assay optical densities greater than 2.0 carried a significant risk of transmitting hepatitis C virus to needlestick victims. No hepatitis C virus seroconversions occurred in medical personnel exposed to hepatitis C virus antibody-negative or hepatitis C virus RNA-negative blood; however, one such exposure resulted in a very mild non-A, non-B, non-C hepatitis.
Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes and a History of Stroke or Transient Ischemic Attack
Authors: Stefan K. James, Robert F. Storey, Nardev S. Khurmi, Steen Husted, Matyas Keltai, Kenneth W. Mahaffey, Juan Maya, Joao Morais, Renato D. Lopes, Jose C. Nicolau, Prem Pais, Dimitar Raev, Jose L. Lopez-Sendon, Susanna R. Stevens, Richard C. Becker
Journal: Circulation (2012)

Background— Patients with acute coronary syndromes and history of stroke or transient ischemic attack (TIA) have an increased rate of recurrent cardiac events and intracranial hemorrhages. Methods and Results— We evaluated treatment effects of ticagrelor versus clopidogrel in patients with acute coronary syndrome with and without a history of prior stroke or TIA in the PLATelet inhibition and patient Outcomes (PLATO) trial. Of the 18 624 randomized patients, 1152 (6.2%) had a history of stroke or TIA. Such patients had higher rates of myocardial infarction (11.5% versus 6.0%), death (10.5% versus 4.9%), stroke (3.4% versus 1.2%), and intracranial bleeding (0.8% versus 0.2%) than patients without prior stroke or TIA. Among patients with a history of stroke or TIA, the reduction of the primary composite outcome and total mortality at 1 year with ticagrelor versus clopidogrel was consistent with the overall trial results: 19.0% versus 20.8% (hazard ratio, 0.87; 95% confidence interval, 0.66–1.13; interaction P =0.84) and 7.9% versus 13.0% (hazard ratio, 0.62; 95% confidence interval, 0.42–0.91). The overall PLATO-defined bleeding rates were similar: 14.6% versus 14.9% (hazard ratio, 0.99; 95% confidence interval, 0.71–1.37), and intracranial bleeding occurred infrequently (4 versus 4 cases, respectively). Conclusions— Patients with acute coronary syndrome with a prior history of ischemic stroke or TIA had higher rates of clinical outcomes than patients without prior stroke or TIA. However, the efficacy and bleeding results of ticagrelor in these high-risk patients were consistent with the overall trial population, with a favorable clinical net benefit and associated impact on mortality. Clinical Trial Registration— URL: http://www.clinicatrials.gov . Unique identifier: NCT00391872.
Defining conditions that lead to the retention of water: The importance of the arterial sodium concentration
Authors: Mohammad A. Shafiee, Andre F. Charest, Surinder Cheema-Dhadli, Daniel N. Glick, Olga Napolova, Jamshid Roozbeh, Elena Semenova, Asheer Sharman, Mitchell L. Halperin
Journal: Kidney International (2005)
Interaction of licorice on glycyrrhizin pharmacokinetics.
Authors: G Cantelli-Forti, F Maffei, P Hrelia, F Bugamelli, M Bernardi, P D'Intino, M Maranesi, M A Raggi
Journal: Environmental Health Perspectives (1994)

The effects of components of aqueous licorice root extract (LE) on the pharmacokinetics of glycyrrhizin (G) and glycyrrhetic acid (GA) were investigated in rats and humans. The aim of this work was to define the role of pharmacokinetics in G toxicity. In the procedure, G and GA were detected in biological fluids by means of recently improved HPLC methods. Significantly lower G and GA plasma levels were found in rats and humans treated with LE compared to the levels obtained with those in which G alone was administered. The pharmacokinetic curves showed significant differences in the areas under the plasma-time curve (AUC), Cmax, and Tmax parameters. The data obtained from urine samples are in agreement with the above results and confirm a reduced bioavailability of G present in LE compared to pure G. This should be attributed to the interaction during intestinal absorption between the G constituent and the several components in LE. The modified bioavailability could explain the various clinical adverse effects resulting from the chronic oral administration of G alone as opposed to LE.
A piece of my mind. A thin green line
Authors: S. Waters
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aspirin as Prophylaxis against Colorectal Cancer
Authors: Aaron J. Marcus
Journal: New England Journal of Medicine (1995)

The article by Giovannucci et al. in this issue of the Journal 1 promises an important advance in cancer prevention. An analysis of the incidence of colorectal cancer among women participating in the Nurses' Health Study according to whether they did or did not use aspirin on a regular basis showed a statistically significant reduction in the incidence of colorectal cancer among women who took four to six aspirin tablets per week for more than 10 years. Known risk factors for colorectal cancer, such as diet, did not influence the results. Moreover, the reduction among women ingesting aspirin was not due . . .
Nitric oxide reduces nontransferrin-bound iron transport in HepG2 cells
Authors: Donatella Barisani, Gaetano Cairo, Enrico Ginelli, Anna Marozzi, Dario Conte
Journal: Hepatology (1999)

Nitric oxide (NO) donors S–nitroso–N–acetylpenicillamine (SNAP) and sodium nitroprusside (SNP) modulate iron regulatory protein (IRP) activity and may, therefore, affect iron uptake through transferrin receptor expression. However, iron also enters the cell as nontransferrin–bound iron (NTBI), and the aim of this study was to evaluate the effects of NO donors on NTBI transport in HepG2 cells, a model of liver physiology. Incubation with SNP and SNAP led to a time– and concentration–dependent reduction in Fe 3+ and Fe 2+ uptake, thus indicating an effect on the transporter rather than on the reductase. In terms of Fe 2+ uptake, no variations in the Michaelis–Menten constant ( K m ) and a reduction in maximum uptake ( V max ) (50, 33, and 16.6 fmol/μg protein/min in control, SNP–, and SNAP–treated cells, respectively) were detected, which suggested a decrease in the number of putative NTBI transport protein(s). Gel shift assays showed that IRP activity was reduced by SNP and slightly increased by SNAP. Northern blot analysis of transferrin receptor messenger RNA (mRNA) levels showed variations similar to those observed for IRPs, but both NO donors increased L–ferritin mRNA levels and had no effect on the stimulator of Fe transport (SFT) mRNA. In conclusion, NO donors significantly reduce NTBI transport in HepG2 cells, an effect that seems to be IRP and SFT independent. Moreover, the reduction in NTBI uptake after NO treatment suggests that this form of iron may play a minor role in the increased hepatic iron stores observed in inflammation or that other liver cells are more involved in this pathological condition.
Prostaglandins and Platelets
Authors: J F Mustard, R L Kinlough-Rathbone, M A Packham
Journal: Annual Review of Medicine (1980)

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is ...Read More
Abstract 533: MicroRNA486-5p is a KRas target involved in promoting cell proliferation in lung cancer
Authors: Mateus N. Aoki, Amanda C. P. Salviatto, Tatiana C. C. Lobo, Ana Cláudia O. Carreira, Mari C. Sogayar, Daniela S. Basseres
Journal: Cancer Research (2014)

Abstract KRAS-induced lung cancer is a very common disease, for which there are currently no effective therapies. Direct targeting of KRAS has failed in clinical trials and intense efforts are underway to identify KRAS targets that play a crucial role in oncogenesis. One promising KRAS-regulated pathway that has so far been overlooked is the microRNA pathway. Even though many microRNAs that regulate expression of KRAS are known, microRNAs regulated by oncogenic KRAS remain largely unknown. Our goal was to identify microRNAs regulated by oncogenic KRAS in lung cells that could contribute to the oncogenic phenotype. Due to a reported positive correlation between microRNA486-5p (miR-486-5p) expression and the presence of KRAS mutations in colon cancer specimens, we decided to investigate in lung cells whether KRAS regulates miR-486-5p. For that purpose we used an immortalized human primary lung epithelial cell line (SALEB) and its isogenic KRAS-transformed counterpart (SAKRAS), as well as lung cancer cell lines with either gain-of-function or loss-of-function of KRAS. We found, in all models tested, a positive correlation between expression of oncogenic KRAS and expression of miR-486-5p. We also found a negative correlation between expression of oncogenic KRAS and expression of miR-486-5p targets, including FoxO1, a tumor suppressor. In order to evaluate how miR-486-5p affects Ras-induced oncogenic properties, we transfected miR-486-5p inhibitor oligonucleotides into KRAS-positive lung cancer cell lines H358 and A549. Inhibition of miR-486-5p expression leads to reduced growth in clonogenic assays and reduced MTT viability. This reduction is not associated with increased cell death, but, as measured by 3H-Thymidine incorporation, it is associated with decreased cell proliferation. Interestingly, transfection of miR-486-5p double-stranded RNA mimic oligonucleotides into KRAS negative lung cancer cell line H1703 or into H358 cells with loss of function of KRAS by RNA interference leads to enhanced proliferation and clonogenicity. Taken together, these results indicate, not only that miR-486-5p is a KRAS target in lung cancer, but also that miR-486-5p acts as an oncomiR contributing to KRAS-induced cell proliferation. Further understanding of miR-486-5p targets could uncover novel pathways for KRAS-induced lung cancer therapy design. Citation Format: Mateus N. Aoki, Amanda C. P. Salviatto, Tatiana C. C. Lobo, Ana Cláudia O. Carreira, Mari C. Sogayar, Daniela S. Basseres. MicroRNA486-5p is a KRas target involved in promoting cell proliferation in lung cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 533. doi:10.1158/1538-7445.AM2014-533
WHICH INDEXES OF MICROCIRCULATORY RESISTANCE AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION ARE LARGER DECREASED BY INTRACORONARY NICORANDIL? NORMAL INDEX OF MICROCIRCULATORY RESISTANCE LEVEL ?
Authors: Noritoshi Ito, Shinsuke Nanto, Ken Nagao, Kei Nishiyama, Yasuji Doi, Yuma Kurozumi, Daisuke Tonomura, Tomoaki Natsukawa, Hirotaka Sawano, Daisaku Masuda, Shizuya Yamashita, Noriaki Yamada, Ken-ichiro Okada, Yasuyuki Hayashi, Tatsuro Kai, Toru Hayashi
Journal: Journal of the American College of Cardiology (2011)
Abstract C78: Integrin αvβ3 drives stemness in the pregnant and neoplastic mammary gland
Authors: Jay Desgrosellier, Jacqueline Lesperance, Laetitia Seguin, David Cheresh
Journal: Cancer Research (2013)

Abstract Carcinoma cell expression of the integrin αvβ3 is associated with enhanced tumorigenicity and metastasis in a diverse array of human tumors. Here, we reveal αvβ3 expression in a subset of CD44+CD24-/low cancer stem cells in human breast tumor biopsies. In fact, αvβ3 is both necessary and sufficient to account for stem-like properties in breast tumor cells, suggesting that αvβ3 may contribute to mammary stem (MaSC)/progenitor cell behavior. While αvβ3 is a luminal progenitor marker in the virgin murine mammary gland, we noted a dramatic, but transient, increase in αvβ3 levels that defined the mammary stem cell pool at mid-pregnancy. Genetic deletion of β3 surprisingly had no effect on luminal progenitor behavior or ductal morphogenesis. In contrast, β3 was specifically required for MaSC clonogenicity and alveologenesis at mid-pregnancy, yet had no influence on MaSCs in the virgin gland. These findings reveal an unexpected role for αvβ3 in driving mammary stemness during pregnancy that may be related to the stem-like properties, and high metastatic potential associated with αvβ3 expression in human breast cancers. Citation Format: Jay Desgrosellier, Jacqueline Lesperance, Laetitia Seguin, David Cheresh. Integrin αvβ3 drives stemness in the pregnant and neoplastic mammary gland. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr C78.
(4) Scleroderma with primary biliary cirrhosis
Authors: R. Clayton, R.J. Cairns, M. Feiwel
Journal: British Journal of Dermatology (1974)

Journal Article (4) Scleroderma with primary biliary cirrhosis Get access R. Clayton, R. Clayton St Bartholomew's Hospital, Kent and St Mary's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar R.J. Cairns, R.J. Cairns St Bartholomew's Hospital, Kent and St Mary's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar M. Feiwel M. Feiwel St Bartholomew's Hospital, Kent and St Mary's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue s10, 1 July 1974, Pages 41–42, https://doi.org/10.1111/j.1365-2133.1974.tb12507.x Published: 01 July 1974