Benign Hypercalcemia and "Benign Hypocalcemia" in the Same Family
Authors: PAUL BANNISTER
Journal: Annals of Internal Medicine (1986)

Brief Report1 August 1986Benign Hypercalcemia and "Benign Hypocalcemia" in the Same FamilyPAUL BANNISTER, M. D., M.R.C.P., PETER SHERIDAN, M.D., M.R.C.P., JOHN DIBBLE, M.D., R. BRIAN PAYNE, M.D.PAUL BANNISTER, M. D., M.R.C.P.Search for more papers by this author, PETER SHERIDAN, M.D., M.R.C.P.Search for more papers by this author, JOHN DIBBLE, M.D.Search for more papers by this author, R. BRIAN PAYNE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-217 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFamilial benign hypercalcemia, first described in 1972 by Foley and colleagues (1), is an autosomaldominant condition characterized by asymptomatic hypercalcemiawithout hypercalciuria. Its clinical and pathogenetic features have been reviewed recently (2). Wedescribe results of a study in another family with benign hypercalcemia, some of whose second-generation offspring were found to have hypocalcemia.A 51-year-old woman had cervical spondylosis and C5 root compression. Biochemical screening showed the following serum concentrations: calcium, 2. 77 mmol/L; inorganic phosphate, 1.08 mmol/L; and albumin, 44 g/L. Repeated serum calcium estimations ranged from 2.72 to 2.84 mmol/L. Serum parathyroid hormone concentrations were normal. We evaluated...References1. FOLEYHARRISONARNAUDHARRISON THCH. Familial benign hypercalcemia. J Paediatr. 1972;81:1060-7. CrossrefMedlineGoogle Scholar2. LAWHEATH WH. Familial benign hypercalcemia (hypocalciuric hypercalcemia): clinical and pathogenetic studies in 21 families. Ann Intern Med. 1985;102:511-9. LinkGoogle Scholar3. PAYNECARVERMORGAN RMD. Interpretation of serum total calcium: effects of adjustment for albumin concentration on frequency of abnormal values and on detection of change in the individual. J Clin Pathol 1979;32:5 3-60. Google Scholar4. FOGH-ANDERSEN N. Ionized calcium analyzer with a built-in pH correction. Clin Chem. 1981;27:1264-7. CrossrefMedlineGoogle Scholar5. KENNYGLEN AA. Tests of phosphate reabsorption. Lancet. 1973;2:158. CrossrefMedlineGoogle Scholar6. PAYNEJONESWALKEREVANS RDAR. Clustering of serum calcium and magnesium concentrations in siblings. Clin Chem. 1986;32:349-50. CrossrefMedlineGoogle Scholar7. BUTLERPAYNEGUNNBURNSPATERSON SRIJC. Correlation between serum ionised calcium and albumin concentrations in two hospital populations. Br Med J [Clin Res]. 1984;289:948-50. CrossrefMedlineGoogle Scholar8. ATTIEGILLSTOCKSPIEGELDOWNSLEVINEMARX MJJARMS. Urinary calcium excretion in familial hypocalciuric hypercalcemia: persistence of relative hypocalciuria after induction of hypoparathyroidism. J Clin Invest. 1983;72:667-76. CrossrefMedlineGoogle Scholar9. DIBBLESHERIDANHAMPSHIREHARDYLOSOWSKY JPRGM. Evidence for secondary hyperparathyroidism in the osteomalacia associated with chronic liver disease. Clin Endocrinol. 1982;15:373-83. CrossrefGoogle Scholar10. MANNINGHENDYPAPAPOULOUSO'RIORDAN RGSJ. Development of homologous immunological assay for human parathyroid hormone. J Endocrinol. 1980;85:161-70. CrossrefMedlineGoogle Scholar11. MENKOBIJVOETFRONEN FOJ. Familial benign hypercalcemia: study of a large family. Q J Med. 1983;52:120-40. MedlineGoogle Scholar12. MARXATTIELEVINESPIEGELDOWNSLASKER SMMARR. The hypocalciuric or benign variant of familial hypercalcemia: clinical and biochemical features in fifteen kindreds. Medicine (Baltimore). 1981;60:397-412. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. James's University Hospital Seacroft Hospital Leeds England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLate-Onset Neonatal Hypocalcemia as an Unusual Presentation in an Offspring of a Mother with Familial Hypocalciuric HypercalcemiaSignificant developmental elevation in serum parathyroid hormone levels in a large kindred with familial benign (hypocalciuric) hypercalcemiaMineral Metabolism 1 August 1986Volume 105, Issue 2Page: 217-219KeywordsAlbuminsAttentionCalciumHospital medicineHypercalcemiaHypocalcemiaParathyroid hormonePathogensPhosphates Issue Published: 1 August 1986 PDF downloadLoading ...