tbuckley/cabot-search huggingface dataset:
Phosphoinositide 3-kinase/AKT Signaling Can Promote AIB1 Stability Independently of GSK3 Phosphorylation
Authors: Macarena Ferrero, Álvaro Avivar, María Carmen García-Macías, Jaime Font de Mora
Journal: Cancer Research (2008)

Abstract The transcriptional coactivator AIB1 is an oncogene overexpressed in different types of tumors, including breast cancer. Although the subcellular compartimentalization of AIB1 seems to be intimately linked to abnormal proliferation, the molecular mechanisms that regulate its subcellular distribution are not well defined. Here, we report that the nuclear accumulation and half-life of AIB1 vary between cancer cell lines. Using these differences as an experimental model, our results reveal that alterations to the Akt signaling pathway and nuclear export determine the stability of AIB1 and nuclear content of this coactivator. Moreover, our results show that AIB1 is degraded in the nucleus by the proteasome in an ubiquitin-dependent manner. However, this process does not require phosphorylation by GSK3, thereby revealing an alternative mechanism for regulating the turnover of AIB1. We define a new region at the carboxy terminus of AIB1 that is required for proteasome-dependent transcriptional activation and is preceded by a PEST domain that is required for adequate protein turnover. Based on differences in Akt signaling and the subcellular distribution of AIB1 between different cell lines, our results suggest that dysregulation of nuclear shuttling and proteasomal degradation may modulate the oncogenic potential of AIB1. [Cancer Res 2008;68(13):5450–9]
Hepatocyte function within a stacked double sandwich culture plate cylindrical bioreactor for bioartificial liver system
Authors: Lei Xia, Talha Arooz, Shufang Zhang, Xiaoye Tuo, Guangfa Xiao, Thomas Adi Kurnia Susanto, Janani Sundararajan, Tianming Cheng, Yuzhan Kang, Hee Joo Poh, Hwa Liang Leo, Hanry Yu
Journal: Biomaterials (2012)
Kinetocardiogram, Phonocardiogram, and Arterial Pulse Waves During Acute Hemodynamic Changes
Authors: ROBERT C. DADDARIO, EDWARD D. FREIS
Journal: Circulation (1966)

The effects of drugs that produce known hemodynamic alterations were assessed on externally recorded pulse waves, heart sounds, and the relationship of these to each other and to the electrocardiogram. The shape of the carotid pulse and the carotid-femoral pulse-wave transmission time difference showed changes that could be related to alterations in central arterial distensibility. The ratio of the second to the first positive inflection, and of the incisura to the first positive inflection of the carotid pulse wave, increased following use of drugs which raised mean arterial pressure and decreased after those which lowered blood pressure. The carotid-femoral transmission time difference decreased with vasopressor agents, increased with amyl nitrite and hexamethonium, and showed no consistent change after isoproterenol. Left ventricular ejection time, measured from the carotid pulse, changed in relation to heart rate, increasing with cardiac slowing and decreasing when the rate accelerated. The ejection time index remained unchanged except for a slight increase following amyl nitrite and a decrease after hexamethonium. Alterations in isovolumic contraction time approximately paralleled changes in diastolic pressure. The ratio of diastolic pressure to isovolumic contraction time provides an index of the rate of rise of left ventricular pressure. The quotient of diastolic pressure divided by isovolumic contraction time increased with adrenergic stimulation (isoproterenol) and decreased after ganglion blockade. It was not significantly changed by angiotensin II, methoxamine, or amyl nitrite. The interval between the onset of QRS and the beginning of the first heart sound (Q-S 1 ), shortened considerably after isoproterenol and moderately following amyl nitrite. It increased after hexamethonium and remained essentially unchanged following angiotensin II or methoxamine. These results suggest that the Q-S 1 interval may reflect ventricular contractility in the absence of mitral valvular disease. The amplitude of the first heart sound appeared to be a sensitive indicator of ventricular contractility increasing with isoproterenol and amyl nitrite, decreasing with hexamethonium and remaining unchanged following use of angiotensin II or methoxamine.
THE REDUCTION OF HYPERCALCEMIA IN CASES OF POLYCYTHEMIA VERA BY PHENYLHYDRAZINE 1
Authors: George E. Brown, Grace M. Roth
Journal: Journal of Clinical Investigation (1928)

The range of variation in serum calcium is relatively narrow in health and in most diseases.The accepted normal level is from 9 to 11 mgm.for each 100 cc. of serum or plasma.Lowered values for serum calcium have been found in tetany (parathyroid), rickets, nephritis, osteomalacia and sprue; elevated values are rare.High values have been found by Wells in terminal acidosis and by Coates and Raiment in gout, averaging 19 mgm.for each 100 cc. of serum; these data, however, have been questioned by Cameron.Horowitz has reported values as high as 16.8 mgm.for each 100 cc. of serum in cases of acute gout, and values as high as 16.2 mgm. in five of fourteen cases of arthritis deformans.Hench found that the serum calcium was normal in four cases of gout and in twenty-five cases of infectious arthritis.The calcium content of the whole blood in healthy subjects has been found by Kramer and Tisdall (16) to vary from 5.3 to 6.8 mgm.for each 100 cc. of blood.Calcium is absent, or present in small amounts, in the corpuscles of the blood.The calcium content of the whole blood and of the serum in cases of polycythemia vera has not been carefully studied, probably because of the relative rarity of the disease.Rabinowitch (18), employing McCallum's gravimetric method (quantitative determination of calcium as calcium oxide) found lowered serum calcium in two cases of polycythemia vera.
39 Valopicitabine (NM283), alone or with peginterferon, compared to peg interferon/ribavirin (pegifn/RBV) re-treatment in hepatitis patients with prior non-response to PEGIFN/RBV: Week 24 results
Authors: N. Afdhal, C. O Brien, E. Godofsky, M. Rodriguez-Torres, S.C. Pappas, P. Pockros, E. Lawitz, N. Bzowej, V. Rustgi, M. Sulkowski, K. Sherman, I. Jacobson, G. Chao, S. Knox, K. Pietropaolo, N. Brown
Journal: Journal of Hepatology (2006)
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
Authors: Bo Liu, Nicholas C. Nicolaides, Sanford Markowitz, James K.V. Willson, Ramon E. Parsons, Jin Jen, Nickolas Papadopolous, Päivi Peltomäki, Albert de la Chapelle, Stanley R. Hamilton, Kenneth W. Kinzler, Bert Vogelstein
Journal: Nature Genetics (1995)
Where next for China?: User fees increase China's health challenges
Authors: Saroj A Jayasinghe
Journal: BMJ (2006)

Where next for China?Rising inequalities in health and wealth are biggest challenge Editor-I write with reference to the editorial by Liu. 1 Life expectancy in China doubled from 35 to 71 years between 1949 and 2001. 2 China's human development index has been rising steadily, and it ranked 85th among countries with an index of 0.755 in 2003. 2According to China's human development report, the national Gini coefficient for income distribution rose to 0.45 in 2002 from 0.3 in 1982. 2 The average income of the highest income tenth is 11 times that of the lowest tenth? 2Disparities in health indicators between urban and rural areas are widening.Life expectancy is 75.2 years for urban residents and 69.6 for rural residents. 2The human development index is 0.816 in urban areas and 0.685 in rural areas.Rural infant mortality at 34% and maternal mortality at 61.9 per 100 000 births are nearly double that in urban areas (14% and 33.1/100 000, respectively).Rural areas have only 2.4 medical personnel per 1000 residents, compared with 5.2 per 1000 residents in urban areas.Regional disparities are widespread, with the western regions faring the worst.Life expectancy for rural residents is less than 65 in Tibet, Yunnan, and Guizhou.Maternal mortality is also highest in the western regions.Tibet ranked lowest in terms of life expectancy (65.81 years), literacy (47%), and human development index (0.562). 2 The region has the lowest number of doctors and hospital beds in China.Only 15% of the entire population of China can afford medical insurance. 2Only 2% of rural migrant workers currently have unemployment insurance. 2Coercive public health policies include forced abortions. 3hina's ambitious aim of building a society in which people are not rich but have adequate food, clothing, and basic necessities for a decent life 2 will require addressing these widening disparities, prioritising health opportunities for all, and acknowledging the inherent, instrumental and constructive 4 roles of freedom in achieving these goals.
Stimulatory effects of dibutyryl cyclic adenosine monophosphate on cytokine production by keratinocytes and fibroblasts
Authors: L-J. Zhou, I. Ono
Journal: British Journal of Dermatology (2000)

Background Clinical studies have shown that ointment containing dibutyryl cyclic adenosine monophosphate (DBcAMP) promotes wound healing. Objectives We aimed to elucidate the mechanisms of the beneficial effect of DBcAMP in wound healing. Methods An investigation was made of the effects of DBcAMP on in vitro cytokine release from cultured keratinocytes and fibroblasts derived from normal human skin. Results DBcAMP stimulated keratinocyte proliferation through increased interleukin (IL)-6 production by fibroblasts, and transiently enhanced production of transforming growth factor (TGF)-β1 by fibroblasts at an early stage of incubation. DBcAMP also stimulated fibroblast proliferation, resulting in further increases in IL-6 and TGF-β1. Conclusions We conclude that this series of stimulative actions on cytokine secretion, together with the facilitation of cell proliferation, contribute to the effects of DBcAMP on the healing of skin ulcers.
Sudden Death During Treatment with Tranylcypromine
Authors: A. M. Womack
Journal: BMJ (1963)

In the present case, although the initial symptoms were severe enough to suggest a diagnosis of encephalitis, recovery was rapid and uneventful, and the patient did not have any sequelae.There were no signs of parenchymal damage to any organ, no anorexia, no albuminuria, and no casts.It is salutary to remember the usefulness of a detailed industrial history.Without it the diagnosis would have remained obscure, and suspicion would not have been focused on the leaking valve.Its adequate repair certainly prevented further cases.I wish to thank Dr. D. M. Freeman for permission to report the case and for
Emphysematous Pyelonephritis as Seen on Technetium-99m DTPA Renal Imaging
Authors: ROGER N. LEEKAM, LALITHA SHANKAR, T ARNOLD BAYLEY
Journal: Clinical Nuclear Medicine (1987)

A Tc-99m DTPA scan performed on a woman with emphysematous pyelonephritis showed a large reniform photon deficient area in the region of the affected kidney. Though radioisotope scanning in renal emphysema has been reported, this finding has not been previously described.
TCT-713 A Minimalist Approach to Trans-Catheter Aortic Valve Implantation, With Limited Use of Computerised Tomography, Transoesophageal Echocardiography and General Anaesthesia - In-Hospital, 30 Day and One Year Outcomes
Authors: James A. Cockburn, Adam de Belder, David Hildick-Smith, Nevil Hutchinson, Ganesh Manoharan, Mark S. Spence, Uday Trivedi
Journal: Journal of the American College of Cardiology (2013)
Efficacy of Influenza Vaccination in HIV-Infected Persons
Authors: Sybil A. Tasker, John J. Treanor, William B. Paxton, Mark R. Wallace
Journal: Annals of Internal Medicine (1999)

Background: Although influenza vaccination is recommended in persons infected with HIV-1, its efficacy is unknown. Objective: To assess the immunogenicity, efficacy, and risks associated with influenza vaccination in persons infected with HIV-1. Design: Randomized, double-blind, placebo-controlled trial. Setting: Outpatient military clinic. Patients: 102 patients with HIV-1 infection. Intervention: Influenza vaccine (n = 55) or saline placebo (n = 47). Measurements: Influenza antibody titers, CD4+ cell counts, and plasma HIV-1 RNA levels at baseline, 1 month after immunization, and 3 months after immunization; viral cultures from persons presenting with respiratory illness; and respiratory symptom interview. Results: Twenty-three placebo recipients (49%) and 16 vaccine recipients (29%) reported respiratory symptoms (P = 0.04). Ten placebo recipients but no vaccine recipients had laboratory-confirmed symptomatic influenza (P < 0.001) (protective efficacy, 100% [95% CI, 73% to 100%]). No effect on plasma HIV-1 RNA levels or CD4+ cell counts was noted. Conclusion: Influenza vaccination is highly effective in HIV-1-infected persons and does not seem to be associated with substantial changes in viral load or CD4 cell count.
Nafcillin Concentration in Cerebrospinal Fluid During Treatment of Staphylococcal Infections
Authors: JAMES G. KANE
Journal: Annals of Internal Medicine (1977)

The nafcillin concentration of simultaneous cerebrospinal fluid (CSF) and serum specimens from nine patients being treated with parenteral nafcillin for staphylococcal infection were measured. Marked variations in the ratio of CSF/serum nafcillin concentration were observed. However, the concentration of nafcillin in the CSF was greater than the minimum lethal concentration (MLC) for Staphylococcus aureus in eight of the nine patients. In five patients with CSF pleocytosis, the nafcillin concentration was three to 100 times the MLC. These results support the recommendation to use nafcillin in doses of at least 100 to 200 mg/kg body weight-day for treatment of meningitis caused by S. aureus.
Tc-99m DTPA-HSA SPECT in a Case of Hemangioma of the Spleen
Authors: HITOYA OHTA, MAKOTO TSUCHISAKI, YASUHIRO MIHARA, HIDEYO TAKEDA, TOSHIKATSU TANIGUCHI, TOMOO KONIBUCHI
Journal: Clinical Nuclear Medicine (1995)

Primary splenic tumors are extremely rare. The authors report the successful diagnosis of splenic hemangioma with radionuclide blood pool scintigraphy.
New “knitted” EGIS esophageal stent allows atraumatic inside-out removal by inversion
Authors: J. Suntharanathan, D. Edwards, D. Mullan, D. Martin, H.-U. Laasch
Journal: Endoscopy (2013)

Modern esophageal stents can be extracted by capture of a purse string. Under traction, braided stents lengthen and narrow. However, strictures are often friable, and extraction can cause hemorrhage or perforation.
PULMONARY VEIN ISOLATION FOR PAROXYSMAL ATRIAL FIBRILLATION CONCOMITANT WITH AORTIC VALVE REPLACEMENT AND/OR CORONARY ARTERY BYPASS GRAFTING: IMPACT OF DILATED LEFT ATRIUM ON LATE OUTCOME
Authors: Satoshi Kainuma, Masataka Mitsuno, Koichi Toda, Shigeru Miyagawa, Hiroyuki Nishi, Yasushi Yoshikawa, Satsuki Fukushima, Kazuhiro Taniguchi, Toshiki Takahashi, Osamu Monta, Hajime Matsue, Yuji Miyamoto, Takayoshi Ueno, Toru Kuratani, Yoshiki Sawa
Journal: Journal of the American College of Cardiology (2013)
Five year prospective study of HIV infection in the Edinburgh haemophiliac cohort.
Authors: R J Cuthbert, C A Ludlam, J Tucker, C M Steel, D Beatson, S Rebus, J F Peutherer
Journal: BMJ (1990)

OBJECTIVE--To identify measures of immune state that reflect the course of HIV related disease in order to predict deterioration of symptoms and assess response to treatment. DESIGN--Five year longitudinal clinical and laboratory study. SETTING--Regional haemophilia centre, university virology laboratory, and Medical Research Council laboratory. PATIENTS--32 Patients with haemophilia A exposed to a single batch of HIV contaminated factor VIII concentrate from the Scottish National Blood Transfusion Service in 1984 who were followed up regularly in Edinburgh (31) or abroad (one). MAIN OUTCOME MEASURES--Counts of circulating T cell subsets (CD4 and CD8); plasma beta 2 microglobulin, neopterin, and IgA concentrations; and delayed type hypersensitivity to multiple skin test antigens. RESULTS--18 Patients who seroconverted after exposure had received significantly more contaminated factor VIII than the 14 who did not (mean 43 (range 9-109) v 15 (3-30) phials, p less than 0.01). The two groups were not distinguishable by other criteria before exposure. The group that seroconverted subsequently showed a progressive fall in mean circulating CD4 lymphocytes and an increase in plasma beta 2 microglobulin and neopterin concentrations. From 1987 patients in this group also showed an increase in mean circulating CD8 lymphocytes and in plasma IgA concentration, neither of which was seen in patients who did not seroconvert. Patients with HIV antibody who developed Centers for Disease Control category IV symptoms within five years after infection showed more extreme changes in all measures, except CD8 lymphocyte count, than those whose symptoms remained in categories II and III. Skin test reactivity declined to barely detectable levels in all patients positive for HIV antibody. CONCLUSIONS--Serial estimates of circulating CD4 lymphocytes and of plasma beta 2 microglobulin concentration are the most reliable measures of disease progression; of these, beta 2 microglobulin concentration seems to be the better predictor of impending serious symptoms. High IgA concentrations reflect rather than predict disease state. Individual variation in most measures is such that a wide range of measurements should be used in assessing the effects of trial treatment in HIV infected patients without symptoms.
Adherence to a metal, polymer and composite by Staphylococcus aureus and Staphylococcus epidermidis
Authors: C.C.P.M. Verheyen, W.J.A. Dhert, J.M.A. de Blieck-Hogervorst, T.J.K. van der Reijden, P.L.C. Petit, K. de Groot
Journal: Biomaterials (1993)
Alterations in the Patterns of Insulin Secretion Before and After Diagnosis of IDDM
Authors: Niall M O'Meara, Jeppe Sturis, Kevan c Herold, Diane M Ostrega, Kenneth S Polonsky
Journal: Diabetes Care (1995)

OBJECTIVE To study the natural history of β-cell dysfunction in an individual who developed insulin-dependent diabetes mellitus (IDDM) over a 13-month period while under observation. RESEARCH DESIGN AND METHODS Insulin secretion rates (ISR) in response to intravenous glucose and mixed meals were estimated by deconvolution of C-peptide levels. RESULTS When fasting glucose and glycosylated hemoglobin concentrations were still within the normal range, insulin secretory responses to intravenous glucose infusion were reduced, but 80- to 100-min secretory oscillations could still be detected. Sequential glucose infusion studies over a 3-month period demonstrated a progressive reduction in insulin secretion. The tight temporal coupling between ultradian oscillations in ISR and glucose observed in nondiabetic subjects was lost. In response to mixed meals, the oscillatory pattern of secretion was preserved, but the magnitude of the secretory responses was reduced. CONCLUSIONS Our results indicate that despite the lower absolute secretory rates, ultradian ISR oscillations persist in the period before and immediately after the onset of IDDM in this subject, but they are less tightly coupled to glucose than in nondiabetic subjects.
Birch Pollen Asthma in The Netherlands
Authors: H. D. Oei, F. T. M. Spieksma, P. L. B. Bruynzeel
Journal: Allergy (1986)

The occurrence of birch pollen asthma is related to high birch pollen concentrations in the air, and therefore this type of asthma is rather common in Scandinavia. High birch pollen concentrations are rare in The Netherlands, but in the spring of 1984 extremely high levels were reached, whereas the concentrations of alder and hazel pollen were very low. During this period nine pollinosis patients known to the allergist developed asthmatic complaints. The appearance and disappearance of the asthmatic symptoms in these patients showed strong correlation with the course of the birch pollen concentration in the air, which strongly suggests that birch pollen asthma can occur in The Netherlands. The significance of this finding may be that this type of asthma can be observed regularly when the birch pollen concentrations are very high. This may also hold for other western European countries.
Stimulation of sarcolemmal sodium-hydrogen exchange in cardiac myocytes as a mediator of the positive inotropic action of 1 adrenergic agonists
Authors: M. C Capogrossi
Journal: Cardiovascular Research (1995)

Journal Article Stimulation of sarcolemmal sodium-hydrogen exchange in cardiac myocytes as a mediator of the positive inotropic action of α1 adrenergic agonists Get access Maurizio C Capogrossi Maurizio C Capogrossi Laboratory of Cardiovascular Science, Gerontology Research Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 2, February 1995, Pages 276–277, https://doi.org/10.1016/S0008-6363(96)88582-8 Published: 01 February 1995
AHA adds public education as top priority.
Authors: S D Ballin, J Johnson
Journal: Circulation (1994)

T o reduce death and disability from cardiovascu- lar diseases, including heart attack and stroke, the American Heart Association (AHA) sup- ports and promotes community and public educational programs.Programs stress disease prevention by pro- moting healthy lifestyles for young people and by en- couraging everyone to eat balanced nutritious meals that are low in fats, to not use tobacco, to control high blood pressure, and to be physically active.To that end, the AHA spent $62.3 million in 1992 to 1993.AHA educational and community service programs are of- fered in US schools, various worksites, and the commu- nities.AHA interactive educational and community programs reached 38.4 million persons in 1992 to 1993.Specifically, AHA school-site programs, offered from preschool through the 12th grade, involved 18.3 million children (one third of all US school children).To ensure that the public is properly informed about disease prevention and health promotion, the AHA has added public education as a priority.Disease preven- tion and health promotion activities include uniform health education curricula; funding for disease preven- tion health programs of the Centers for Disease Control and Prevention, the National Heart, Lung, and Blood Institute, and the Office on Smoking and Health; and physical fitness and exercise.The AHA is working with volunteer groups to ensure that comprehensive health education is included and adequately funded in health care reform legislation, in the Reauthorization of Elementary and Secondary Ed- ucation Act, and in Goals 2000, a framework for edu- cation reform.The AHA is pleased that some health care reform bills in Congress have included comprehensive school health education.Comprehensive school health educa- tion is a critical component of preventive health serv- ices.However, comprehensive health education is only part of the whole comprehensive school health program.To ensure that children develop the essential knowledge and skills they will need to maintain their health and the health of their future families, we must promote both a comprehensive school health program and a healthy school environment.A comprehensive school health program must focus on tobacco-free school environments, nutritious and healthy school meals, physical fitness activities, employee wellness programs, and a comprehensive school health education curricula.Moreover, comprehensive school health programs must ensure that schoolwide policies support and reinforce what is taught in the classroom.