tbuckley/cabot-search huggingface dataset:
A ONE YEAR PROSPECTIVE STUDY ON ANKLE STABILITY AND LANDING TECHNIQUE: THE OCCURRENCE OF ANKLE AND KNEE INJURIES IN ELITE BALL TEAM ATHLETES
Authors: H van der Does, M Brink, K Lemmink
Journal: British Journal of Sports Medicine (2014)

Background In team sports lower extremity injuries account for over 50% of all injuries, indicating the importance of early detection of athletes at risk. Objective Investigating the predictive value of ankle stability and landing technique at baseline for ankle and knee injury occurrence during the consecutive season in indoor team sport athletes. Design Prospective longitudinal cohort study. Setting (Sub-)elite level basketball, korfball or volleyball athletes. Participants Out of 58 athletes 42 athletes (age: 22.2±3.9 yr, height: 184.5±11.8 cm, mass: 79.0±15.2 kg) met the inclusion criteria; being ≥18 years, performed baseline measurement and completion of season. Risk factor assessment Athletes performed the Single-Leg Jump-Landing (SLJL) test and the Landing Error Scoring System (LESS) Jump at baseline. SLJL test resulted in a dynamic stability index (DSI) in medial-lateral (ml), anterior-posterior (ap) and vertical (v) direction for frontal, diagonal and lateral jump direction. High DSI indicates poor stability. The LESS determines an athlete's landing technique; high score represents poor landing technique. Main outcome measurements Ankle and knee injuries were registered according to the FIFA registration system. Results 9 ankle injuries and 7 knee injuries were reported. Athletes that reported an ankle injury scored a significant (P≤.05) higher DSI compared to non-injured athletes in diagonal ap (0.072±0.01 vs 0.066±0.01), diagonal v (0.350±0.06 vs 0.305±0.05) and lateral ap (0.057±0.01 vs 0.047±0.01) direction. Athletes that reported a knee injury scored a non-significant higher LESS score (7.46±1.38) compared to non-injured athletes (6.20±2.0). Conclusions Athletes who sustained an ankle injury during the season showed higher DSI at baseline. Athletes with a knee injury showed tendency toward poorer landing technique. Both tests seem feasible to screen athletes at baseline giving insight in high-risk athletes. Prevention programs could be implemented preventing these athletes from sustaining an injury.
Ultrasound scanning and 99mTc sulphur colloid scintigraphy in diagnosis of Budd-Chiari syndrome.
Authors: P R Powell-Jackson, J Karani, R J Ede, H Meire, R Williams
Journal: Gut (1986)

Ultrasound scanning and 99mTc sulphur colloid scintigraphy are widely used in the diagnosis of the Budd-Chiari syndrome and have been compared at the time of presentation in 18 patients in whom the diagnosis was subsequently confirmed by histology and hepatic venography. Ultrasound was diagnostic in 16 (87%). The findings seen most often included hepatic vein abnormalities, caudate lobe hypertrophy with decreased reflectivity and compression of the inferior vena cava. Additional information not shown by scintigraphy included intracaval tumour, or thrombosis, and concomitant portal vein thrombosis. Although scintigraphic abnormalities were present in all patients, only in three (17%) was the 9classical9 appearance of increased uptake and/or enlargement of the caudate lobe present. In one patient with nonspecific abnormalities on ultrasound, scintigraphy gave a positive diagnosis and it is in such cases that scintigraphy should continue to be used.
Phorate Exposure and Incidence of Cancer in the Agricultural Health Study
Authors: Rajeev Mahajan, Matthew R. Bonner, Jane A. Hoppin, Michael C.R. Alavanja
Journal: Environmental Health Perspectives (2006)

We recently reported a link between use of the organophosphate pesticide phorate and risk of prostate cancer among applicators with a family history of prostate cancer in the Agricultural Health Study (AHS).This finding, together with findings of associations between other organophosphate pesticides and cancer more broadly, prompted us to examine phorate exposure and overall cancer incidence in the AHS. Adding 3 years of follow-up and using more detailed exposure information allowed us to see whether the prostate cancer finding held.The AHS is a prospective study of licensed restricted-use pesticide applicators from North Carolina and Iowa. To our knowledge, this is the largest examination of workers occupationally exposed to phorate. Pesticide exposure and other information was collected using two self-administered questionnaires completed from 1993 to 1997. Poisson regression was used to calculate rate ratios (RR) and 95% confidence intervals (CI), adjusting for potential confounders.Phorate use was not related to the incidence of all cancers combined or to any individual cancer, although we had insufficient numbers to study non-Hodgkin lymphoma or leukemia, which have been linked to organophosphates in other studies. Although prostate cancer risk was not significantly related to phorate use overall or among those without a family history, the risk tended to increase among applicators with a family history of prostate cancer. The interaction RR was 1.53 (95% CI, 0.99-2.37).The observed statistical interaction suggests a gene-environment interaction between family history and phorate exposure in the incidence of prostate cancer, but other explanations are also possible.
Origin of Intestinal Atresia of Newborn
Authors: S. Jerome Dickinson
Journal: JAMA (1964)

Current concepts of the pathogenesis of intestinal atresia of the newborn cast considerable doubt on the classical theory of failure of recanalization. Clinical and experimental evidence make it probable that atresias are the consequence of intrauterine abdominal catastrophes occurring late in fetal life. This concept is illustrated by a case report, and the technical advantages of early operations and the use of a reservoir attachment to a decompressing ileostomv are discussed.
P341Hydrogen sulphide treatment of human adipose derived stem cells increases their proliferation, decreases their mitochondrial activity and enhances their antioxidant defenses
Authors: L Kiss, A Csizmazia, ZS Benko, G Marosi, U Schumacher, E Dongo
Journal: Cardiovascular Research (2014)

Purpose: The potential of cell-based therapies in diseases involving ischemia-reperfusion is greatly hampered by the excessive loss of the administered cells in the harsh, oxidative environment. Our earlier studies indicated that preconditioning of human adipose derived stem cells (ASC) with the hydrogen sulphide donor sodium sulphide (NaHS) increased their survival and efficacy in an in vitro model of cell-based therapy for myocardial infarct. Our current aim was to better understand the mechanism of action of sodium sulphide on ASCs.
Elevated mitochondrial gene expression during rat liver regeneration after portal vein ligation*1
Authors: Yasuhiro Shimizu, Hiroshi Suzuki, Yuji Nimura, Shigemi Onoue, Masato Nagino, Masashi Tanaka, Takayuki Ozawa
Journal: Hepatology (1995)

We explored the molecular basis of mitochondrial energy production during rat liver regeneration after portal vein ligation. Ligation of the left branch of the portal vein induces an increase in the weight of the nonligated lobe, counterbalancing the reduced weight of the ligated lobe. Using this model, we investigated changes in mitochondrial DNA-binding proteins, mitochondrial DNA, and mitochondrial messenger RNA (mRNA) in rat hepatocytes of the nonligated lobes. The amount of mitochondrial DNA-binding protein increased maximally (200% to 300% of the preoperative level) at 12 hours after the operation, before an increase (390%) in mitochondrial DNA content at 24 hours, and parallel to an increase (240%) in mitochondrial mRNA levels at 12 hours. These results suggest that the energy supply for liver regeneration is achieved through enhancement of mitochondrial DNA replication as well as transcription, in which the mitochondrial DNA-binding proteins probably play regulatory roles. We also found that in the nonligated lobes, mRNA levels of hepatocyte growth factor increased to a detectable level only 12 hours after the operation. These molecular biochemical data help explain why preoperative portal vein embolization, which is a modification of portal vein branch ligation, is an effective method to prevent posthepatectomy liver failure.
Portal hypertension and variceal bleeding: An AASLD single topic symposium
Authors: Norman D. Grace, Roberto J. Groszmann, Guadalupe Garcia-Tsao, Andrew K. Burroughs, Luigi Pagliaro, Robert W. Makuch, Jaime Bosch, Gregory V. Stiegmann, Michael J. Henderson, Roberto de Franchis, Judith L. Wagner, Harold O. Conn, Juan Rodes
Journal: Hepatology (1998)
OBSERVATIONS OF THE MECHANISM AND EFFECTS OF ARTERIOVENOUS FISTULAS ON CARDIOVASCULAR HEMODYNAMICS BY CARDIAC CATHETERIZATION
Authors: Rajeeve Subbiah, Aditya Bakhshi, Brian O&apos;Murchu, Matthew McClure, Eric Schwartz, Alfred Bove, David Fiss, Michael Brown, Nelson Wolf, Riyaz Bashir, Sheila Weaver, Jesse Goldman
Journal: Journal of the American College of Cardiology (2012)
Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver
Authors: Laura N. Cruz, Mateus T. Guerra, Emma Kruglov, Albert Mennone, Celia R. S. Garcia, Ju Chen, Michael H. Nathanson
Journal: Hepatology (2010)

Multidrug resistance associated protein 2 (Mrp2) is a canalicular transporter responsible for organic anion secretion into bile. Mrp2 activity is regulated by insertion into the plasma membrane; however, the factors that control this are not understood. Calcium (Ca2+) signaling regulates exocytosis of vesicles in most cell types, and the type II inositol 1,4,5-triphosphate receptor (InsP3R2) regulates Ca2+ release in the canalicular region of hepatocytes. However, the role of InsP3R2 and of Ca2+ signals in canalicular insertion and function of Mrp2 is not known. The aim of this study was to determine the role of InsP3R2-mediated Ca2+ signals in targeting Mrp2 to the canalicular membrane. Livers, isolated hepatocytes, and hepatocytes in collagen sandwich culture from wild-type (WT) and InsP3R2 knockout (KO) mice were used for western blots, confocal immunofluorescence, and time-lapse imaging of Ca2+ signals and of secretion of a fluorescent organic anion. Plasma membrane insertion of green fluorescent protein (GFP)-Mrp2 expressed in HepG2 cells was monitored by total internal reflection microscopy. InsP3R2 was concentrated in the canalicular region of WT mice but absent in InsP3R2 KO livers, whereas expression and localization of InsP3R1 was preserved, and InsP3R3 was absent from both WT and KO livers. Ca2+ signals induced by either adenosine triphosphate (ATP) or vasopressin were impaired in hepatocytes lacking InsP3R2. Canalicular secretion of the organic anion 5-chloromethylfluorescein diacetate (CMFDA) was reduced in KO hepatocytes, as well as in WT hepatocytes treated with 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA). Moreover, the choleretic effect of tauroursodeoxycholic acid (TUDCA) was impaired in InsP3R2 KO mice. Finally, ATP increased GFP-Mrp2 fluorescence in the plasma membrane of HepG2 cells, and this also was reduced by BAPTA. Conclusion: InsP3R2-mediated Ca2+ signals enhance organic anion secretion into bile by targeting Mrp2 to the canalicular membrane. Hepatology 2010
Lipid Raft–Specific Knockdown of Src Family Kinase Activity Inhibits Cell Adhesion and Cell Cycle Progression of Breast Cancer Cells
Authors: Taro Hitosugi, Moritoshi Sato, Kazuki Sasaki, Yoshio Umezawa
Journal: Cancer Research (2007)

Abstract Src family kinase (SFK) is known to control various cell functions, but the significance of the location of its activation was largely unknown. We herein revealed that SFK activation occurs in lipid rafts. Based on this finding, we have developed a lipid raft–targeted SFK inhibitory fusion protein (LRT-SIFP) that inhibits the SFK activity in lipid rafts. LRT-SIFP has a peptide inhibitor of SFK and a lipid raft–targeting sequence in which two cysteine residues are palmitoylated for clustering in lipid rafts. LRT-SIFP was found to inhibit cell adhesion and cell cycle progression of human breast cancer cell lines MCF-7 and MDA-MB231. On the other hand, the cell functions of MCF-7 cells were found to be not affected with a previously developed peptide inhibitor of SFK that lacks the lipid raft–targeting sequence. In addition, when we replaced the targeting sequence of LRT-SIFP with the consensus sequence for geranylgeranylation to make LRT-SIFP unable to cluster in lipid rafts, this mutated LRT-SIFP did not show any effect on the above cell functions of MCF-7 cells. Furthermore, in contrast to the breast cancer cell lines, LRT-SIFP did not show any inhibitory effect on cell adhesion and cell cycle progression of human normal cell line HEK293. The present lipid raft–specific knockdown of SFK activity would potentially be useful for selective cancer therapy to prevent tumorigenesis and metastasis of breast cancer cells. [Cancer Res 2007;67(17):8139–48]
PHYSICAL EXAMINATION FINDINGS IN FIBROMUSCULAR DYSPLASIA: A REPORT OF THE UNITED STATES REGISTRY FOR FIBROMUSCULAR DYSPLASIA
Authors: Stacey L. Poloskey, Jeffrey Olin, James Froehlich, Xiaokui Gu, J. Michael Bacharach, Bruce Gray, Mark Grise, Michael Jaff, Soo Hyun Kim, Eva Kline-Rogers, Pamela Mace, Alan Matsumoto, Robert McBane, Thom Rooke, Heather Gornik
Journal: Journal of the American College of Cardiology (2012)
Alexithymia, ‘pensée opératoire’ and Predisposition to Coronopathy
Authors: M. Defourny, P. Hubin, D. Luminet
Journal: Psychotherapy and Psychosomatics (1976)

The 'behavioral pattern A' and the 'B' pattern in selected groups of male populations in the framework of a prospective and predictive study of a large population of civil service employees is compared. The Personality Inventory of Lazare, Klerman and Armor and the auto-questionnaire of Bortner were used to differentiate the 'A' and 'B' group populations. Selected cards from Murray's TAT seem more appropriate in this respect and demonstrate the lack of efficiency of certain questionnaires in areas of psychosomatic research. Moreover the selected TAT card responses provide some evidences of 'pensée opératoire' or alexithymia in 'A' group subjects whatever its metapsychological implication.
Fatal Pneumonia in Children
Authors: Joan Stephenson
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fortuitous Imaging of a Primary Adrenocortical Carcinoma With Tc-99m HDP
Authors: ELMER J. PACHECO, ALBERT J. MORENO, CARLOS JIMENEZ, ALAN CARPENTER, STEVEN STEINBAUM, KERRY BRADY
Journal: Clinical Nuclear Medicine (1995)

The importance of evaluating nonfunctional adrenal masses in the right clinical setting is discussed. A 60-year-old man was initially diagnosed of having a localized lung carcinoma. Metastatic work-up showed an adrenal mass that was not deemed to be related to the lung primary. Although biochemical testing revealed that the adrenal mass was nonfunctional, adrenal scintigraphy was not performed. On resection, the lung neoplasm was shown to be a poorly differentiated adenocarcinoma. Radiologic follow-up of the adrenal finding was recommended. A year later, the patient presented with an abdominal mass that was visualized by bone scintigraphy and, on resection, proved to be adrenocortical carcinoma. In retrospect, the lung mass was a metastasis of an adrenocortical carcinoma.
Drug Deaths Decrease
Authors: Cyril H. Wecht
Journal: JAMA (1972)

To the Editor.—  Throughout the United States, most major metropolitan areas have witnessed an increase during the past five years in deaths due to the abuse of drugs and chemicals. This had been true in the greater Pittsburgh metropolitan area until this year.  Beginning in 1967, we witnessed a progressive increase in drug abuse deaths; from eight deaths in 1967 to a high of 64 in 1971. For the first seven months of 1972, we have observed a reverse in this trend, with 12 deaths recorded. This represents a reduction of 83% from the corresponding period in 1971. We have not recorded a death in the past 19 months from glue sniffing, solvent sniffing, aerosol inhalation, or cough syrup abuse.  We attribute this reduction in drug deaths during 1972 to reduction in the availability of hard narcotics (related to police efforts), chemical discouragement (addition of oil of mustard to glue),
PATIENT-PROSTHESIS MISMATCH ON OCTOGENARIANS AFTER AORTIC VALVE REPLACEMENT: IMPACT ON EARLY AND LATE MORTALITY
Authors: Buu-Khanh Lam, Elsayed Elmestekawy, Harry Lapierre, Diem T. Tran, Marc Ruel, Thierry G. Mesana
Journal: Journal of the American College of Cardiology (2011)
Mutations in NHLRC1 cause progressive myoclonus epilepsy
Authors: Elayne M Chan, Edwin J Young, Leonarda Ianzano, Iulia Munteanu, Xiaochu Zhao, Constantine C Christopoulos, Giuliano Avanzini, Maurizio Elia, Cameron A Ackerley, Nebojsa J Jovic, Saeed Bohlega, Eva Andermann, Guy A Rouleau, Antonio V Delgado-Escueta, Berge A Minassian, Stephen W Scherer
Journal: Nature Genetics (2003)
Relation between phenotype and banal melanocytic naevi.
Authors: J S English, A J Swerdlow, R M MacKie, C J O'Doherty, J A Hunter, J Clark, D J Hole
Journal: BMJ (1987)

In a study of risk factors for the development of melanocytic naevi in relation to the pathogenesis of malignant melanoma 197 white adults were examined by four dermatologists and naevus counts correlated with several other features. Highly significant associations were found between large numbers of banal acquired melanocytic naevi and the ability to tan easily without burning (skin types 3 and 4; relative risk 4.6), brown or hazel eyes (relative risk 3.5), green or grey eyes (relative risk 3.5) and brown or black hair (relative risk 3.7). No significant associations with numbers of naevi were shown for parity or use of oral contraceptives or other steroid hormones. This is the first study to find any relation between melanocytic naevi and phenotypic factors in a white population.
Long-Term Dipeptidyl-Peptidase 4 Inhibition Reduces Atherosclerosis and Inflammation via Effects on Monocyte Recruitment and Chemotaxis
Authors: Zubair Shah, Thomas Kampfrath, Jeffrey A. Deiuliis, Jixin Zhong, Colleen Pineda, Zhekang Ying, Xiaohua Xu, Bo Lu, Susan Moffatt-Bruce, Rekha Durairaj, Qinghua Sun, Georgeta Mihai, Andrei Maiseyeu, Sanjay Rajagopalan
Journal: Circulation (2011)

Background— Dipeptidyl-peptidase 4 (DPP-4) inhibitors are increasingly used to accomplish glycemic targets in patients with type II diabetes mellitus. Because DPP-4 is expressed in inflammatory cells, we hypothesized that its inhibition will exert favorable effects in atherosclerosis. Methods and Results— Male LDLR −/− mice (6 weeks) were fed a high-fat diet or normal chow diet for 4 weeks and then randomized to vehicle or alogliptin, a high-affinity DPP-4 inhibitor (40 mg · kg −1 · d −1 ), for 12 weeks. Metabolic parameters, blood pressure, vascular function, atherosclerosis burden, and indexes of inflammation were obtained in target tissues, including the vasculature, adipose, and bone marrow, with assessment of global and cell-specific inflammatory pathways. In vitro and in vivo assays of DPP-4 inhibition (DPP-4i) on monocyte activation/migration were conducted in both human and murine cells and in a short-term ApoE −/− mouse model. DPP-4i improved markers of insulin resistance and reduced blood pressure. DPP-4i reduced visceral adipose tissue macrophage content (adipose tissue macrophages; CD11b + , CD11c + , Ly6C hi ) concomitant with upregulation of CD163. DPP-4 was highly expressed in bone marrow–derived CD11b + cells, with DPP-4i downregulating proinflammatory genes in these cells. DPP-4i decreased aortic plaque with a striking reduction in plaque macrophages. DPP-4i prevented monocyte migration and actin polymerization in in vitro assays via Rac-dependent mechanisms and prevented in vivo migration of labeled monocytes to the aorta in response to exogenous tumor necrosis factor-α and DPP-4. Conclusion— DPP-4i exerts antiatherosclerotic effects and reduces inflammation via inhibition of monocyte activation/chemotaxis. These findings have important implications for the use of this class of drugs in atherosclerosis.
Diminished Tc-99m HMPAO Pulmonary Uptake in Ex-Smokers
Authors: WEI-JEN SHIH, JONG-KANG LEE, JOHN COUPAL, YIH-LOON LAI, FRANK GRUNWALD, HANS BIERSACK
Journal: Clinical Nuclear Medicine (1995)

Normally, there is no localization of Tc-99m HMPAO in the lungs. Tc-99m uptake in smokers' lungs has been reportedly higher than in nonsmokers. Thus, the lung uptake may be used as a barometer of cigarette smoking. To assess whether there is a decrease in pulmonary uptake of Tc-99m HMPAO after cessation of smoking, the authors investigated the lung uptake of 31 male ex-smokers in comparison to smokers and nonsmokers. Anterior and posterior images were taken 10 minutes after intravenous injection of 20–25 mCl of Tc-99m HMPAO. Regions-of-interest over the liver and lungs in the anterior view were calculated. Duration of abstinence from smoking ranged from 5 months to 50 years. The mean lung/liver uptake in ex-smokers was 0.489 · 0.019 (sem). In a previous report, the mean lung/liver ratio for smokers (N = 30) was 0.805 · 0.040 (sem) and 0.408 · 0.019 (sem) for nonsmokers (N = 25). Compared with smokers, the lung/liver uptake ratio of ex-smokers was significantly lower (P < 7 x 10−9). The lung/liver uptake ratio of ex-smokers was significantly higher than that of nonsmokers (P < 0.005). The authors conclude that pulmonary Tc-99m HMPAO uptake of smokers is significantly diminished after quitting smoking. However, the lung uptake of ex-smokers is higher than that of non-smokers. The uptake in the lung induced by smoking appears to be partially reversible after the cessation of smoking.
The Role of Vascular Dynamics in the Development of Atherosclerosis
Authors: Meyer Texon
Journal: JAMA (1965)

This report identifies the inception and progressive pathology of atherosclerosis resulting from the effects of hydraulic forces inherent in the circulatory system.<sup>1</sup>Vascular dynamics relates the effect of hydraulic forces to the biological response of blood vessels. The forces and principles involved are directly comparable to those which prevail in all hydraulic systems with due regard to local conditions of flow and hydraulic characteristics.<sup>2</sup>The laws of fluid mechanics are fully applicable to the hydrobiological conditions found in the human circulatory system, and the composite effects of their operation are both prerequisite and conducive to atherosclerosis. Previous reports<sup>3,4</sup>have correlated atherosclerotic lesions found at autopsy with their localization in the circulatory system as determined by hydraulic forces. Rigid and flexible model hydraulic systems built to simulate the specifications of human blood vessels with respect to pulsatile flow, volumetric flow, velocity of flow, and anatomical geometry confirm the