tbuckley/cabot-search huggingface dataset:
Idiopathic Intracranial Hypertension—Reply
Authors: Michael Wall, Michael McDermott, Mark Kupersmith
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis and management of hereditary haemochromatosis
Authors: M. A. v. Bokhoven, C. T. B. M. v. Deursen, D. W. Swinkels
Journal: BMJ (2011)

Hereditary haemochromatosis is an autosomal recessive disorder with a genetic prevalence of 0.4% in northern Europeans but a much lower clinical penetrance Those affected are at increased risk of cirrhosis of the liver and hepatocellular carcinoma Symptoms are often non-specific at presentation and include fatigue and arthropathy If transferrin saturation and serum ferritin are raised, test for C282Y mutation of the HFE gene First degree relatives of patients with clinically overt haemochromatosis can be screened for C282Y and H63D polymorphisms Regular phlebotomy is the main treatment, although newly developed therapeutic approaches show promise Hereditary haemochromatosis is an autosomal recessive genetic disease in which increased intestinal absorption of iron causes accumulation in tissues, primarily the liver, sometimes leading to organ damage.Liver deposits may result in cirrhosis and even death.A systematic review has shown that about 0.4% of people of northern European descent have the genetic mutation that increases the risk of developing haemochromatosis,1 but the clinical penetrance of the mutation is much lower than the genetic prevalence.Symptoms and signs are initially non-specific, so the disease is often diagnosed at a late stage when substantial organ damage has already occurred.The challenge is to avoid both overdiagnosis and underdiagnosis.Since the discovery of the genetic mutation, new knowledge has come to light on the pathophysiology and course of the disease.This has led to new recommendations on diagnosis and treatment.In addition, new treatments are under evaluation.We review 1 2 3 9/16/21, 11:11 AM Diagnosis and management of hereditary haemochromatosis | The BMJ https://www.bmj.com/content/342/bmj.c7251.full.print2/12 evidence from experimental and observational studies, systematic reviews, and guidelines to summarise for the general reader the clinical presentation, diagnosis, including early screening options, and management of hereditary haemochromatosis. Sources and selection criteriaInitially, we made an extensive search of Medline, Embase, and the Cochrane Library for papers published until December 2009 using both MESH headings and free text related to hereditary haemochromatosis.In addition, we retrieved national and international guidelines and checked the references of the papers that we obtained.The overall methodological quality of the papers was low.Although many reviews were available, they were mostly narrative.The more recent literature seems to be of better quality.
Inhibition of nuclear factor kappa B activation and inducible nitric oxide synthase transcription by prolonged exposure to high glucose in the human keratinocyte cell line HaCaT
Authors: K. Nakai, Y. Kubota, H. Kosaka
Journal: British Journal of Dermatology (2004)

Background In human skin, inducible nitric oxide synthase (iNOS) appears to be a key enzyme during wound healing and has roles in protection from infection. We speculated that diabetic skin complications such as delayed wound healing and skin infection were due to iNOS activity altered by high glucose in skin keratinocytes. Objectives The purpose of this study was to see how high levels of glucose affect iNOS activity in the human keratinocyte cell line (HaCaT). Methods HaCaT cells were exposed to high glucose for 1 day or 10 days. We measured nitric oxide (NO) end product nitrite in the culture medium using the Griess reagent, and intracellular tetrahydrobiopterin (BH4, a cofactor of NOS) content by using high-performance liquid chromatography, analysed the expression level of iNOS mRNA by the reverse transcriptase-polymerase chain reaction method and evaluated the DNA binding activity of nuclear factor kappa B (NF-κB) by enzyme-immunoassay. Results Short-term exposure (1 day) to a high level of glucose increased BH4 and iNOS activity at the post-translational level. However, long-term exposure (10 days) to high glucose downregulates NF-κB binding activity and inhibits iNOS transcription and its activity. Conclusions Pretreatment with high glucose for 10 days down-regulated NF-κB activity and inhibited iNOS transcription and NO production, implying the involvement of a deficiency in NO synthesis in both skin infection and impaired wound healing in diabetic patients.
Diastolic vibration of the interventricular septum in aortic insufficiency.
Authors: G D Cope, J A Kisslo, M L Johnson, S Myers
Journal: Circulation (1975)

The echocardiograms of 46 patients with aortic insufficiency which manifested typical high frequency vibrations of the anterior mitral valve leaflet were reviewed. All patients had overt clinical evidence of aortic insufficiency which was confirmed by angiography in 17 cases. In 17 cases (eight of whom underwent catheterization and angiography), high frequency diastolic vibrations of the interventricular septum of similar frequency to those on the anterior mitral leaflet were observed. This finding was not seen in 100 control echocardiograms from patients without clinical evidence of aortic insufficiency, and represents a previously undescribed echocardiographic manifestation of this lesion.
Severe hypotension after first dose of enalapril in heart failure.
Authors: J G Cleland, H J Dargie, H McAlpine, S G Ball, J J Morton, J I Robertson, I Ford
Journal: BMJ (1985)

The new, long acting converting enzyme inhibitor enalapril was given to 26 patients with moderate to severe heart failure. In 23 cases the mean systolic blood pressure fell from 120 (SD 22) to 108 (25) mm Hg without adverse effects. Profound hypotension with severe bradycardia and sweating, however, occurred in three patients, most pronounced two to four hours after the first dose. The haemodynamic and biochemical changes in these patients were similar to those seen in patients with severe symptomatic hypotension after the first dose of the converting enzyme inhibitor captopril, except that with enalapril the changes occurred later and were longer lasting. Evidence of myocardial damage and reversible renal failure was seen in one patient, and acute reversible deterioration in renal function occurred in one other. In patients with heart failure converting enzyme inhibitors should be administered initially under strict medical supervision with appropriate facilities available for dealing with occasional profound hypotension.
Bronchial atresia with corresponding segmental pulmonary emphysema
Authors: L. K. Lacquet, M. Fornhoff, R. Dierickx, N. Buyssens
Journal: Thorax (1971)

This paper presents a 13-year-old boy suffering from congenital bronchial atresia of the anterior and apicoposterior segments of the left upper lobe with corresponding emphysema, and emphysema with bronchial atresia in the anterobasal segment of the left lower lobe. The aetiology of congenital localized emphysema is not always clear. In the group with a demonstrable check-valve mechanism, which permits air to enter but not to leave the lung, there is either internal stenosis or external compression of the bronchus. The condition is called idiopathic if no cause can be identified, but in some of these cases microscopical examination has disclosed alveolar fibrosis which prevents the rigid alveoli from collapsing on expiration. In these cases the check-valve mechanism exists at an alveolar level. In the small group of rare cases of bronchial atresia, air which enters through a collateral ventilation cannot be expired by the same route, and in these cases there is likewise a check-valve mechanism at an alveolar level; this is associated with the occurrence of localized emphysema, characterized by the presence of normal bronchial ramifications which arise from a bronchial sac with a blind proximal ending. The bronchial atresia is believed to occur after the 15th week of intrauterine life, probably as a result of vascular insufficiency. A preoperative diagnosis is possible on the basis of a plain chest radiograph, which shows the localized emphysema as well as an abnormal hilus shadow representing the mucus-filled blind bronchial stump; the diagnosis can be established also by a bronchogram, which shows a filling defect in the affected part of the lung. Surgical treatment is indicated.
1159-193 Simvastatin combined with ramipril improved endothelium-dependent vasodilation and fibrinolysis potential and reduced oxidant stress and inflammation markers in hypercholesterolemic patients
Authors: Kwang K Koh, Seung H Han, Jeong Y Ahn, Woong C Kang, Wook-Jin Chung, Tae H Ahn, Eak K Shin
Journal: Journal of the American College of Cardiology (2004)
Cryoablation of Non-valvular Paroxysmal Atrial Fibrillation does not Change Tissue Doppler Derived Left Ventricular Diastolic Parameters in Short Term
Authors: Cansın Tulunay Kaya, Siamak Mousavi, Başar Candemir, Ali Timuçin Altın, Aydan Ongun, Mustafa Kılıçkap, Ömer Akyürek, Muharrem Güldal, Celal Kervancıoğlu, Çetin Erol
Journal: Journal of the American College of Cardiology (2013)
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
Authors: Varun K Gupta, Lisa Scheunemann, Tobias Eisenberg, Sara Mertel, Anuradha Bhukel, Tom S Koemans, Jamie M Kramer, Karen S Y Liu, Sabrina Schroeder, Hendrik G Stunnenberg, Frank Sinner, Christoph Magnes, Thomas R Pieber, Shubham Dipt, André Fiala, Annette Schenck, Martin Schwaerzel, Frank Madeo, Stephan J Sigrist
Journal: Nature Neuroscience (2013)
Results from a Genome-wide Search for Predisposing Genes in Sarcoidosis
Authors: MANFRED SCHÜRMANN, PHILIPP REICHEL, BERTRAM MÜLLER-MYHSOK, MAX SCHLAAK, JOACHIM MÜLLER-QUERNHEIM, EBERHARD SCHWINGER
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Sarcoidosis is a systemic disease of granulomatous inflammation and unknown etiology. An inherited predisposition is involved, and many candidate susceptibility genes have been tested in association studies. We have applied the more general strategy of genome-wide microsatellite linkage analysis to identify chromosomal regions that contribute to the risk of sarcoidosis. On the basis of 225 microsatellite markers tested in 63 families with affected siblings (138 patients) and multipoint nonparametric linkage (NPL) analysis, we found the most prominent peak (six adjacent markers including D6S1666; NPL score = 2.99; p = 0.001) at the major histocompatibility complex (MHC). Six minor peaks (p < 0.05) were found on chromosomes 1 (D1S1665 ), 3 (D3S1766 ), 7 (D7S821 and D7S3070), 9 (D9S934), and the X chromosome (DXS6789). A subset of nine families with more than two affected siblings (30 patients) contributed little to the peak at the MHC (D6S1666; NPL score = 0.79; p = 0.21). Our results point to locus heterogeneity of susceptibility to sarcoidosis, with a major effect of the MHC.Keywords:
Efficacy and safety overview of a new inhaled corticosteroid, QVAR (hydrofluoroalkane-beclomethasone extrafine inhalation aerosol), in asthma
Authors: Jennifer A.Vanden Burgt, William W. Busse, Richard J. Martin, Stanley J. Szefler, David Donnell
Journal: Journal of Allergy and Clinical Immunology (2000)
Murder of the Newborn: A Psychiatric Review of Neonaticide
Authors: PHILLIP J. RESNICK
Journal: American Journal of Psychiatry (1970)

The author believes that the killing of a newborn baby is a separate entity from other filicides, differing in regard to the diagnosis, motives, and legal disposition of the murderer. Whereas most filicides are committed for "altruistic" reasons, most neonaticides are carried out simply because the child is not wanted. The author notes the different psychological characterisctics of mothers who commit these two crimes. Legal considerations and the present status of neonaticide are also discussed.
Points from Letters: Alcohol and Road Accidents
Authors: J. A. Coden
Journal: BMJ (1964)

Until benzidine was taken off the market because of carcinogenic risks to those engaged in its manufacture the test most widely used was the Gregersen slide-test.'It was in general use on the Continent and in America, and was becoming more generally used in this country.It was recommended in many of the textbooks.5In general practice and in hospital side- wards there are obvious objections to tests, such as the test-tube benzidine and ortho- tolidine tests commonly employed in clinical laboratories, which may give positive results with gum-bleeding and after the eating of meats in moderate amount.Ogilvie, who was the first in this country to describe the Gregersen slide-test,8 affirmed that with it a blue or green-blue colour appearing within 30 seconds is proof of the presence of occult blood irrespective of the patient's diet, with the obvious exceptions of foods with a high blood-pigment concentration such as liver, black pudding, and bone-marrow.Now it is recognized that salicylates also should be withheld.Bockus' employs the Gregersen slide-test as a routine procedure.Benzidine is now produced under safe con- ditions of manufacture and is again on the market.Put up in waxed paper the powders will last indefinitely.The Greger- sen slide-test is cheap and simple and can be performed just as quickly as the tablet tests.Its reliability has been widely proved over the years, and it should be finding its way back into our hospital side-rooms and our consulting-rooms.-Iam, etc., Edinburgh 9. S. LIPETZ.
The Pelican and After: A Novel About Emotional Disturbance
Authors: Sara C. Charles
Journal: JAMA (1984)

This is an autobiographical novel about a young man who spent the greater part of his latency and adolescent periods at Bruno Bettelheim's Orthogenic School in Chicago. He apparently was identified as having the "mind of a murderer" at age 8 years, and the novel depicts his conflicts, fantasies, and struggles to neutralize his suicidal, homicidal, and sexually aggressive impulses. The story is a sad one indeed—of a young child who sees himself as having little worth, lacking the positive qualities needed for interaction with other persons, and whose perception of himself is always tinged by his experience and his history. The exact precipitant of his entry into the school is unclear, but he seems convinced that the security afforded by the walls of the school is needed protection for the impulses that plague him. The major portion of the book is set within the environment of the school peopled
Risk of Death Associated With Nesiritide in Patients With Acutely Decompensated Heart Failure
Authors: Keith D. Aaronson, Jonathan Sackner-Bernstein
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ON THE INHERITANCE OF INSANITY
Authors: K. Pearson
Journal: BMJ (1905)

in French and by Dr. Deighton of Cambridge, the party was conducted to the Casino, where there was a vocal and orchestral concert, into which the National Anthems of both countries were introduced, and the visitors left next morning by the new train-de-luxe for Paris, with very pleasing and grateful remembrances of their delightful welcome.Vi8its to Biarritz, Pau, Cautereta, and Sai8es.Another party of medical men and ladies left Paris on the morning of May 14th on a visit to Biarritz, Pau, Cauterets, and Salies.The party, numbering forty, travelled in special cars, and every arrangement had been so carefully thought out that the journey was performed without undue fatigue.Biarritz was reached in the evening, and the town was illuminated in honour of the visitors, who were taken in carriages to the Casino, passing through cheering crowds.At the Casino the Mayor of Biarritz and the medical practi- tioners entertained the party to a vin d'honneur.The morning of May 15th was spent in driving about the vicinity of Biarritz, and at mid-day a banquet was held in the old palace of the Empress Eugenie.In the afternoon the guests left for Pau, where they were accorded a coriial reception by the Municipality, and afterwards attended a splendid banquet at the Winter Palace.Surgeon-General Keogh, in the course of a speech delivered on this occasion, took the opportunity of expressing the thanks of the party for the hospitality and many kindnesses they had received.On the morning of May i6th the guests were taken in motors to visit the town of Pau and the country round.-Shortly after mid-day they left for Cauterets, where they spent ,some time in making an excursion to the waterfalls on the way to the Lac de Gaube.In the evening a banquet was held in their honour at Cauterets.On May I7th the party left for Lourdes, where they spent one hour and then departed for Salies de Bearn.In the evening a magnificent reception was much enjoyed, and many speeches were delivered.On May 13th Arcachon was reached, and a short time was spent in this noted health resort, after which most of the party returned to Paris.The courtesy of Dr. Meillon of Cauterets, who accompanied the travellers from Paris, was greatly appreciated.
Mental images: Always present, never there
Authors: Fred W. Mast
Journal: Behavioral and Brain Sciences (2005)

Recent research on visual mental imagery plays an important role for the study of visual hallucinations. Not only are mental images involved in various cognitive processes, but they also share many processes with visual perception. However, we rarely confuse mental images with percepts, and recent neuroimaging studies shed light on the mechanisms that are differently activated in imagery and perception.
Prevalence of Human Immunodeficiency Virus Infection in Ethnic Minority Homosexual/ Bisexual Men
Authors: M. Samuel, W. Winkelstein
Journal: JAMA (1987)

To the Editor.—  Recently, ethnic minorities, particularly blacks, have been reported to be disproportionately represented among the total of US cases of acquired immunodeficiency syndrome. 1,2 However, to date, no human immunodeficiency virus (HIV) seroprevalence data have been reported for homosexual/bisexual men who are members of ethnic minorities. If risk factors for infection differ between ethnic groups, strategies for research and epidemic control could be importantly affected.  Study.—  In San Francisco, 1034 single men 25 through 54 years of age have been recruited via an area probability sample for prospective study of the epidemiology and natural history of acquired immunodeficiency syndrome and HIV infection (the San Francisco Men's Health Study). 3 Of the study cohort, 800 classified themselves as homosexual/bisexual; of these, 100 belong to ethnic minority groups.      Table 1 shows the composition of the cohort according to ethnicity and prevalence of HIV infection at the time of entry into
MECHANISM OF ACTION OF ACCELERANTS ON SKIN PENETRATION
Authors: A.C. ALLENBY, N.H. CREASEN, J.A.G. EDGINTON, J.A. FLETCHER, C. SCHOCK
Journal: British Journal of Dermatology (1969)

Journal Article MECHANISM OF ACTION OF ACCELERANTS ON SKIN PENETRATION Get access A.C. ALLENBY, A.C. ALLENBY Search for other works by this author on: Oxford Academic Google Scholar N.H. CREASEN, N.H. CREASEN Search for other works by this author on: Oxford Academic Google Scholar J.A.G. EDGINTON, J.A.G. EDGINTON Search for other works by this author on: Oxford Academic Google Scholar J.A. FLETCHER, J.A. FLETCHER Search for other works by this author on: Oxford Academic Google Scholar C. SCHOCK C. SCHOCK Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue s4, 1 August 1969, Pages 47–55, https://doi.org/10.1111/j.1365-2133.1969.tb16061.x Published: 01 August 1969
Abstract A04: HOXB13 regulates androgen receptor expression in prostate cancer
Authors: Shuangling Chen, William B. Isaacs
Journal: Cancer Research (2013)

Abstract The androgen receptor (AR), a member of the nuclear receptor superfamily of ligand-regulated transcription factors, plays a pivotal role in the initiation and progression of prostate cancer. HOXB13, a prostate-specific homeodomain-containing transcription factor, interacts with AR to regulate the cellular response to androgens (Norris et al. Mol Cell 2009). The overexpression of HOXB13 in LNCaP and VCaP cells led to an increased expression of AR at the mRNA and protein levels; upon the reduction of endogenous HOXB13 by siRNA in LNCaP cells and VCaP cells, the amount of AR decreased at the mRNA and protein levels. Conversely, when AR was knocked down with siRNA in LNCaP cells, the level of HOXB13 proteins increased but not mRNA level, indicating that HOXB13 promotes the expression of AR, and AR promotes HOXB13 degradation. HOXB13 promoting AR expression might be one of the mechanisms by which HOXB13 regulates AR function. Note: This abstract was not presented at the conference. Citation Format: Shuangling Chen, William B. Isaacs. HOXB13 regulates androgen receptor expression in prostate cancer. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr A04.