tbuckley/cabot-search huggingface dataset:
The Utilization of Technetium-99m CPI as a Myocardial Perfusion Imaging Agent in Exercise Studies
Authors: S T BENJAMIN SIA, B LEONARD HOLMAN, STEPHEN CAMPBELL, JOHN LISTER-JAMES, ROBERT J. ENGLISH, JAMES F. KRONAUGE, ALAN DAVISON, ALLUN G. JONES
Journal: Clinical Nuclear Medicine (1987)

Myocardial perfusion imaging with Tc-99m carbomethoxyisopropylisonitrile (CPI) was compared with TI-201 imaging in 22 patients who were assessed for coronary artery disease. There was agreement between Tc-99m CPI and TI-201 imaging for detecting segmental myocardial ischemia and fixed defects in 185/198 (93%) of left ventricular segments. There was also an excellent correlation between the two tracers for the detection of coronary artery disease (18/22 patients). Myocardial clearance of the isonitrile complex was slow, and there was no redistribution into ischemic regions; the normal to ischemic myocardial ratio remained relatively constant over time. Reinjection at rest was used to distinguish transient ischemia from infarction. The isonitrile complex was excreted rapidly via the hepatobiliary system. After 3 hours, background activity was reduced to about 20% of the initial activity. Tc-99m CPI appears comparable to TI-201 thallous chloride for detecting coronary artery disease. Tc-99m CPI may be useful as a myocardial imaging agent because there is no myocardial redistribution, myocardial clearance is slow, and clearance from background tissues is rapid.
Allergic patients do not comply with doctors' advice to stop owning pets
Authors: S. Coren
Journal: BMJ (1997)

Doctors should work towards elimination of all firearms and knivesEditor-With the publication of the Cullen report into the shooting of several children at a school in Scotland 1 and the cross party support in parliament to increase the controls on handguns, the moment is ripe for the medical profession to pursue a new health campaign.Over the past three or four decades the profession has had some success in raising public awareness of the risks of cigarette smoking and through that, probably, in saving lives.The reduction of the suicide rate is an objective of the Health of the Nation for England, yet suicide rates are still rising among young men. 2 Homicide is a major political issue.Weapons, especially firearms and knives, contribute to both these forms of premature death.Elimination of all firearms and knives that are surplus to domestic and industrial requirements would not solve either problem entirely, but it would make an important contribution.We believe that the profession, through the BMA and one or two royal colleges (particularly the Royal College of Psychiatrists), could develop policies about weapons control.The prime minister has already indicated that he would introduce controls on knives if a workable definition for the surplus ones was drawn up.
1115-67 The medicine, angioplasty, or surgery study (MASS II): Quality of life of patients with symptomatic multivessel coronary disease-24 months of follow-up
Authors: Myrthes Emy Takiuti, Dirceu Carrara, Shirley A.B Hiscock, Desiderio Favarato, Neusa H Lopes, Whady A Hueb, Sergio A Oliveira, Jose A.F Ramires
Journal: Journal of the American College of Cardiology (2004)
Patterns of Gallium Uptake in Amebic Liver Abscesses
Authors: RAMESH C. VERMA, CAROLINE NGO, ISSA YAGHMAI
Journal: Clinical Nuclear Medicine (1989)

Imaging with Ga–67 and Tc–99m sulfur colloid was performed in ten patients with amebic liver abscesses. The most common imaging pattern appeared to be with the sharp identification of a “rim” sign on delayed Ga–67 imaging, from 48–72 hours.
Resistance of infant leukemia with MLL rearrangement to tumor necrosis factor-related apoptosis-inducing ligand: a possible mechanism for poor sensitivity to antitumor immunity
Authors: T Inukai, X Zhang, M Goto, K Hirose, K Uno, K Akahane, A Nemoto, K Goi, H Sato, K Takahashi, H Honna, K Kagami, K Nakamoto, H Yagita, K Okumura, T Koyama-Okazaki, S Nakazawa, K Sugita
Journal: Leukemia (2006)
PTH-157 The use of a Faecal Calprotectin in Routine Clinical Practice can help avoid Dilema and Significantly Reduce Unnecessary Colonoscopy
Authors: M W Johnson, T Cacciattolo, S Shieh, K Lithgo, T Price
Journal: Gut (2013)

<h3>Introduction</h3> The new faecal calprotectin (FC) assessment kits are capable of differentiating between organic and functional bowel disease with a 93% sensitivity and 96% specificity (Rheenen. BMJ.2010). Where the diagnosis is unclear, FC can be used to spare unnecessary invasive colonoscopy. Functional (Irritable bowel syndrome - IBS) symptoms occur in 60% of ulcerative colitis (UC) and 40% of Crohn’s disease patients (Keohane. AJG. 2010). This can cause a notoriously difficult management dilemma, which in turn can lead to over treatment of presumed flares in the inflammatory bowel disease (IBD). <h3>Objectives</h3> 1) To assess the ability of FC in differentiating between functional and organic disease where the diagnosis was uncertain, and to review the number of potentially unnecessary colonoscopies that could be spared. 2) To assess the management outcome in symptomatic IBD patients when using FC to determine IBS from inflammatory symptoms. <h3>Methods</h3> Over a 6month period FC data was collected from both new gastroenterology referral patients and known IBD patients, where a colonoscopy was being considered because of diagnostic uncertainty about whether they were suffering from organic or functional (IBS) symptoms. A retrospective review was them performed to assess the diagnostic and management outcome. <h3>Results</h3> In total 100 FC assessments were performed in new referral patients and 44 in known IBD patients where there had been a diagnostic dilemma. In the new patients colonoscopy was spared in 70% (70/100), including 55/63 with normal FC (&lt; 60), 6/7 with borderline FC (60–100), and 9/30 with high FC (&gt; 100). Some of these patients did however opt for a CT cologram were positive findings were seen in 0/6 of those with normal FC, 1/2 (1 diverticular disease) with borderline FC, and 7 (2 normal, 4 diverticular disease, 1 cancer) with high FC. Despite normal FC results 6 new patients went on to have a colonoscopy, 5 of which were normal and 1 demonstrated a low grade dysplastic tubular adenoma. In the IBD patients colonoscopy was spared in 84% (37/44), including 13/14 with normal FC, 8/9 with borderline FC and 16/21 with high FC. In the IBD cohort the FC changed management in 10/14 with normal results, 4/9 with borderline results and 16/21 with high results. <h3>Conclusion</h3> With the increasing demand being made on colonoscopy throughout UK, a greater utilisation of faecal calprotectin into clinical practise could help safely relieve some of this burden. Faecal calprotectin can be strongly influential in the management of known IBD patients, and provides confidence for clinicians to focus in on treating functional bowel symptoms and tailor down escalating management regimes in those with normal results. <h3>Disclosure of Interest</h3> None Declared.
Lasers and psoriasis
Authors: P.V. Harrison
Journal: British Journal of Dermatology (1986)

Journal Article Lasers and psoriasis Get access P.V. Harrison P.V. Harrison Beaumont Hospital, Slyne Road, Lancaster LAi 2JF, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue 3, 1 September 1986, Page 386, https://doi.org/10.1111/j.1365-2133.1986.tb05758.x Published: 01 September 1986
Food‐dependent exercise‐induced anaphylaxis: a report of two cases and determination of wheat‐γ‐gliadin as the presumptive allergen
Authors: E. Morita, Y. Yamamura, S. Mihara, Y. Kameyoshi, S. Yamamoto
Journal: British Journal of Dermatology (2000)

Water/salt‐insoluble wheat proteins have been identified as the most frequent allergenic foodstuffs in patients with food‐dependent exercise‐induced anaphylaxis (FDEIA) in Japan. However, the specific allergenic proteins in wheat‐dependent exercise‐induced anaphylaxis have not been well defined. Challenge testing, skin testing and a fluoroenzyme immunoassay were used for diagnosis in two patients suspected by history of having wheat‐dependent exercise‐induced anaphylaxis. Gel chromatography and IgE immunoblotting followed by N‐terminal amino acid sequencing were used to identify the allergenic wheat protein. The challenge test revealed that both patients had FDEIA. The skin tests and the immunoassay results suggested that wheat gluten was the allergen in both patients. Gel chromatography of wheat gluten revealed that the antigens had molecular weights ranging from 40 to 250 kDa. IgE immunoblotting and subsequent N‐terminal amino acid sequencing revealed that wheat‐γ‐gliadin was the antigen predominantly bound by IgE in the two patients.
Safety of aclidinium bromide/formoterol fumarate fixed dose combination (FDC) in COPD: Pooled analyses of three phase III studies
Authors: Stephanie Korn, Edward Kerwin, James F. Donohue, Pomy Shrestha, Anne Leselbaum, Alejhandra Lei
Journal: European Respiratory Journal (2014)

Background 

Two 24-week Phase III studies (ACLIFORM and AUGMENT) and a 28-week AUGMENT extension study assessed the efficacy and safety of twice-daily (BID) aclidinium/formoterol FDC in patients with moderate or severe COPD.

Aim 

To assess adverse events (AEs) in a pooled analysis of the three Phase III studies.

Method 

These were randomized, double-blind, placebo- and active-controlled studies. Patients received placebo, formoterol 12 µg, aclidinium 400 µg, FDC 400/6 µg or FDC 400/12 µg BID. Patients who continued into the extension study from AUGMENT remained on the same treatment. AEs were monitored.

Results 

The pooled placebo-controlled safety population included 3398 patients (mean age 64 years; 61% male; 49% current smoker; 59% moderate COPD).

Overall, the frequency and severity of AEs and the number of deaths was comparable across groups (Table). Additionally, the only AEs reported by ≥3% of patients, and with a frequency ≥0.5% higher in either FDC group versus placebo, were nasopharyngitis, headache, urinary tract infection, sinusitis and nausea. Discontinuations due to AEs were most common with placebo. COPD exacerbation was the only AE leading to discontinuation in ≥1% of patients in any group and was more frequent with placebo (2.3%) than FDC (1.0–1.9%).

Conclusions 

Overall, the safety profile of FDC BID was comparable with placebo and with the individual monotherapies.

![Figure][1]  [1]: pending:yes
Orange-bolus Obstruction
Authors: P. M. Binns
Journal: BMJ (1961)

MBRICJLM M_ c4 omUthe various approaches to the treatment of disease I think we should all bear in mind that we will not be suffering from the side-effects, the risks, nor footing the bill.Pinel wrote,3 " My faith in pharmaceutical pre- parations was gradually lessened, and my scepticism went at length so far as to induce me never to have recourse to them, until moral remedies had completely failed."However much our beliefs and impressions of treatment are biased by our personal needs, drug-firm persuasion, and the climate of contemporary opinion, we still have to explain the remarkable results obtained by Brown and Conolly in England, Todd, Wood- ward, and Butler in America, and others long before tranquillizers, barbiturates, deep insulin, E.C.T., and leucotomy were known.
Plantar malignant melanoma in a white Caucasian population
Authors: P.K. DWYER, R.M. MACKIE, D.C. WATT, T.C. AITCHISON
Journal: British Journal of Dermatology (1993)

Fifty‐one white Caucasian patients from the west of Scotland, with stage I primary malignant melanoma arising on the plantar surface were studied. Subungual lesions were excluded from the study. Clinical and pathological features were related to survival, and compared with a group of 239 cases of clinical stage 1 melanoma of the lower limb, excluding the foot, collected in the same geographical area over the same period of time (1979–84). The average age of patients with plantar melanoma was 67 years and was significantly older than those with leg melanomas, in whom the mean age was 53 years.
Definitions in palliative care
Authors: I G Finlay, R V H Jones
Journal: BMJ (1995)

EDITOR,--The recent correspondence about palliative care services for cardiology fails to differentiate between the three distinct yet interacting aspects of palliative care.

The palliative approach is relevant to all patients with incurable conditions. It emphasises the importance of considering psychosocial and spiritual aspects as well as the purely physical. It includes consideration of family and domestic carers. Most specialties and all general practitioners look after patients with life threatening disease; attention …
Smaller caliber renal arteries are a novel feature of uromodulin-associated kidney disease
Authors: Aleksander Prejbisz, Lorenz Sellin, Elżbieta Szwench-Pietrasz, Magdalena Woznowski, Ilona Michałowska, Dirk Blondin, Dariusz Sajnaga, Jorg T. Epplen, Mieczysław Litwin, Gabriele Dekomien, Magdalena Januszewicz, Udo Helmchen, Joanna Matuszkiewicz-Rowińska, Marcin Adamczak, Andrzej Więcek, Andrzej Januszewicz, Lars C. Rump
Journal: Kidney International (2015)
THE TREATMENT OF DIPHTHERIA.
Authors: DOWLING BENJAMIN
Journal: JAMA (1896)

To thread one's way through the enormous and conflicting mass of statistics that have been published in regard to the treatment of diphtheria by means of antitoxin, or serum therapy, is an undertaking to appall the stoutest heart. By patience and application we may observe a few facts, however, standing prominently and seemingly substantial enough to remain as useful monuments to guide us through the wilderness of uncertainties to some safe vantage ground. <h3>THE RESULTS IN PRIVATE PRACTICE.</h3> A study of the results of the antitoxin treatment in private practice presents much greater difficulties, for obvious reasons, than does the study of the same subject in institutional practice. Exactly what the results have been can not be ascertained, as it is not possible to obtain the personal and private statistics of each individual physician as to its results and his death rate; nor would it be wise, since such results
CLINICAL USE OF EXTRACORPOREAL OXYGENATION WITH OXYGENATOR-PUMP
Authors: James A. Helmsworth
Journal: JAMA (1952)

Oxygenation of the blood, elimination of carbon dioxide, and maintenance of circulation by means of a pump that has the effect of ventricular contractions constitute the objectives in mechanical substitution for the lungs and heart. A review of the physiological details involved in the development of substitutes for the lungs and the heart is beyond the scope of this report and will therefore not be attempted. Furthermore, the contributions of Kolff, Jongbloed, Bjork, Gibbon, and Dennis have already furnished answers to many of the basic problems involved in extracorporeal oxygenation and circulation. Recent reports of work done in this field seem to have led many practitioners to believe that the use of a mechanical heart-lung machine for total by-pass during intracardiac surgery is an imminent possibility. However, the logical steps in the evolution of such physiological-mechanical systems must still include experiments designed to measure the machine's effects when used on
Degeneracy in the Army.
Authors: Eugene S. Talbot
Journal: JAMA (1900)

Chicago, Oct. 4, 1900. <h3>To the Editor:</h3> —<i>The American Journal of Insanity</i>for July contains an article by Dr. Charles E. Woodruff on "Degeneracy in the Army," and remarks anent army musicians that "with the high musical sense there seems to be a liability of inferiority in some other ways, for they possess physical stigmata in far greater proportion than does the average soldier. They have to be managed by entirely different rules of discipline." What is true of army musicians is also true of musicians in state institutions for defective classes, etc. The most degenerate individuals of an institution are usually to be found among the members of the band. In many cases they are the most difficult to manage. A notable illustration is that of the band at the New York State Reformatory at Elmira. At one time more than two-thirds of the band were dressed in
THE EPIDEMIOLOGY OF A RABBIT RESPIRATORY INFECTION
Authors: Leslie T. Webster
Journal: The Journal of Experimental Medicine (1924)

100 adult rabbits taken at random from The Rockefeller Institute animal house were examined clinically, anatomically, and bacteriologically for evidence of respiratory infection. 58 of these rabbits proved to have snuffles; 42 were free of the disease. Bacterium lepisepticum was the predominating organism in the nasal flora of 55 of the 58 rabbits showing snuffles. This organism was also cultured from the nasal passages of eight normal rabbits. Bacillus bronchisepticus was associated with Bacterium lepisepticum in the nasal flora of eight rabbits with snuffles. It was also cultured from the nares of twenty-two normal rabbits. Fifteen normal rabbits showed neither Bacterium lepisepticum nor Bacillus bronchisepticus.
Clinical Testing of New Drugs
Authors: Vincent J. Gagliardi
Journal: JAMA (1965)

ABSTRACT The book reflects growing concern with the need for better testing of new drugs. The need is felt in two main areas. In preclinical testing broader and more predictive animal toxicity tests should be used, including those designed to show teratogenicity. In clinical investigations there should be better study-design and attention to clinical pharmacology. The goals are, to insure that drugs do what they are supposed to do and that their limitations are fully explored.Participating in drug evaluation in general, and contributing to this book in particular, are personnel associated with research, the pharmaceutical industry, clinical investigators, statisticians, and regulatory agencies. Twenty-one contributors have written 27 chapters which tell what happens to a drug from inception to reception. Each observes his field, comments on the limitations (which are often the limitations of science itself), and indicates what improvements can be made. There is some repetition and overlap, but in
Management of Medical Problems in Pregnancy — Inflammatory Bowel Disease
Authors: Robert M. Donaldson
Journal: New England Journal of Medicine (1985)

WHETHER diagnosed as Crohn's disease or ulcerative colitis, chronic nonspecific inflammatory bowel disease is particularly likely to afflict young adults. It is therefore not at all unusual to encounter women with inflammatory bowel disease who are pregnant or would like to become pregnant. The care of such patients frequently raises difficult questions, because all aspects of inflammatory bowel disease — its diagnosis, complications, and treatment — have serious implications for the pregnant patient. During pregnancy, the patient requires particularly rigorous care, but the basic principles of caring for such patients do not change. Indeed, they should be followed more closely . . .
Taxes and Subsidies to Improve Diet—Reply
Authors: Dariush Mozaffarian, Kenneth S. Rogoff, David S. Ludwig
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radial Keratotomy in the 1990s and the PERK Study
Authors: Perry S. Binder
Journal: JAMA (1990)

When radial keratotomy was introduced into the United States, the procedure was performed using razor blade fragments whose extension was determined by sighting on a linear scale block; up to 24 or more incisions of various length per eye were used. As with any new procedure, significant complications occurred. The technique was declared "a risky procedure of unproven long-term success."<sup>1</sup>The Prospective Evaluation of Radial Keratotomy (PERK) Study was begun in March 1982 as a nine-center trial with 10 participating surgeons that was designed to determine the outcome of a single standardized technique for simple (no astigmatism) myopia.<sup>2</sup>About the time the PERK Study began, current surgical procedures were just being applied by the majority of radial keratotomy surgeons (diamond blades, ultrasonic measurement of corneal thickness, reduction of the length and number of incisions to ⩽16).<sup>3</sup>In this issue ofThe Journal, Waring and coworkers<sup>4</sup>provide
Prescribing of drugs for use outside their licence in palliative care: survey of specialists in the United Kingdom
Authors: H. Pavis, A. Wilcock
Journal: BMJ (2001)

A quarter of all prescriptions in palliative medicine are for licensed drugs that are used for unlicensed indications or that are given by an unlicensed route. Such prescriptions may affect two thirds of inpatients in specialist palliative care units. 1 2 Doctors have been recommended to record in the patient's notes the reason for prescribing outside the licence; to explain, where possible, the position to the patient (and carers, if appropriate) in sufficient detail to allow informed consent to be given; and to inform other professionals involved in the care of the patient of such prescribing, so that misunderstandings are avoided.3 Given the widespread use of drugs outside their licence in palliative care, strict adherence to these recommendations may be impractical. In view of the implications of these …