tbuckley/cabot-search huggingface dataset:
High frequency of MYD88 mutations in vitreoretinal B-cell lymphoma: a valuable tool to improve diagnostic yield of vitreous aspirates
Authors: Irina Bonzheim, Sabrina Giese, Christoph Deuter, Daniela Süsskind, Manfred Zierhut, Maria Waizel, Peter Szurman, Birgit Federmann, Janine Schmidt, Leticia Quintanilla-Martinez, Sarah E. Coupland, Karl Ulrich Bartz-Schmidt, Falko Fend
Journal: Blood (2015)
Type A or B Behavior?
Authors: Ernest H. Friedman
Journal: JAMA (1974)

<h3>To the Editor.—</h3> In a previous letter (219:385, 1972), I noted that the personality stereotype described by the type A behavior pattern of Meyer Friedman and colleagues yielded inconsistent findings in their prospective study of coronary artery disease. Now, reevaluation has occurred from within. At the annual meeting of the American Psychosomatic Society on March 31, 1974, in Philadelphia, Jenkins, Zyzanski, and Rosenman called for a redefinition of type A. Their new description of the coronaryprone personality is that of an individual who is noncompetitive with his peers, in contrast with their original description of an individual with a profound inclination and eagerness to compete, with persistent desire for recognition and advancement. This revised profile is consistent with characterization of the coronary candidate as a phlegmatic individual (type B in the style of response) with low self-esteem (<i>Exercise Testing and Exercise Training in Coronary Heart Disease</i>. New York, Academic Press,
Beta-Blockers to Prevent Gastroesophageal Varices in Patients with Cirrhosis
Authors: Roberto J. Groszmann, Guadalupe Garcia-Tsao, Jaime Bosch, Norman D. Grace, Andrew K. Burroughs, Ramon Planas, Angels Escorsell, Juan Carlos Garcia-Pagan, David Patch, Daniel S. Matloff, Hong Gao, Robert Makuch
Journal: New England Journal of Medicine (2005)

Nonselective beta-adrenergic blockers decrease portal pressure and prevent variceal hemorrhage. Their effectiveness in preventing varices is unknown.We randomly assigned 213 patients with cirrhosis and portal hypertension (minimal hepatic venous pressure gradient [HVPG] of 6 mm Hg) to receive timolol, a nonselective beta-blocker (108 patients), or placebo (105 patients). The primary end point was the development of gastroesophageal varices or variceal hemorrhage. Endoscopy and HVPG measurements were repeated yearly.During a median follow-up of 54.9 months, the rate of the primary end point did not differ significantly between the timolol group and the placebo group (39 percent and 40 percent, respectively; P=0.89), nor were there significant differences in the rates of ascites, encephalopathy, liver transplantation, or death. Serious adverse events were more common among patients in the timolol group than among those in the placebo group (18 percent vs. 6 percent, P=0.006). Varices developed less frequently among patients with a baseline HVPG of less than 10 mm Hg and among those in whom the HVPG decreased by more than 10 percent at one year and more frequently among those in whom the HVPG increased by more than 10 percent at one year.Nonselective beta-blockers are ineffective in preventing varices in unselected patients with cirrhosis and portal hypertension and are associated with an increased number of adverse events. (ClinicalTrials.gov number, NCT00006398.)
Preservation of the Neurovascular Bundles Is Associated with Improved Time to Continence After Radical Prostatectomy But Not Long-term Continence Rates: Results of a Systematic Review and Meta-analysis
Authors: Fairleigh Reeves, Patrick Preece, Jada Kapoor, Wouter Everaerts, Declan G. Murphy, Niall M. Corcoran, Anthony J. Costello
Journal: European Urology (2014)
Intravenous Potassium Chloride Therapy-Reply
Authors: Margaret J. Bia
Journal: JAMA (1982)

ABSTRACT In Reply.— With respect to Dr Fribourg's questions to us, we did mean to say that we would infuse as much as 80 to 100 mEq/L of potassium per hour to suppress the ventricular irritability in a patient with profound hypokalemia (less than 2 mEq/L). If this is done by two peripheral infusions containing 40 to 50 mEq of potassium per liter, we agree that this represents a large volume load. However, most patients with such profound hypokalemia also have substantial volume contraction from either vomiting or excessive diuretics. In addition, if the fluid is given as D5W, it will be distributed over totalbody water (ie, over 42 L in a 70-kg person), which will leave less than 10% of each liter in the intravascular space. We would like to state that such a clinical situation, ie, one where hypokalemia is so profound as to cause ventricular irritability,
Multicenter Phase II Study of Nordic Fluorouracil and Folinic Acid Bolus Schedule Combined With Oxaliplatin As First-Line Treatment of Metastatic Colorectal Cancer
Authors: Halfdan Sørbye, Bengt Glimelius, Åke Berglund, Tone Fokstuen, Kjell Magne Tveit, Morten Brændengen, Dagfinn Øgreid, Olav Dahl
Journal: Journal of Clinical Oncology (2003)

Purpose This Nordic multicenter phase II study evaluated the efficacy and safety of oxaliplatin combined with the Nordic bolus schedule of fluorouracil (FU) and folinic acid (FA) as first-line treatment in metastatic colorectal cancer. Patients and Methods Eighty-five patients were treated with oxaliplatin 85 mg/m 2 as a 2-hour infusion on day 1, followed by a 3-minute bolus injection with FU 500 mg/m 2 and, 30 minutes later, by a bolus injection with FA 60 mg/m 2 every second week. The same doses of FU and FA were also given on day 2. Results Fifty-one of 82 assessable patients achieved a complete (n = 4) or partial (n = 47) response, leading to a response rate of 62% (95% CI, 52% to 72%). Nineteen patients showed stable disease, and 12 patients had progressive disease. Thirty-eight of the 51 responses were radiologically confirmed 8 weeks later (confirmed response rate, 46%; 95% CI, 36% to 58%). The estimated median time to progression was 7.0 months (95% CI, 6.3 to 7.7 months), and the median overall survival was 16.1 months (95% CI, 12.7 to 19.6 months) in the intent-to-treat population. Neutropenia was the main adverse event, with grade 3 to 4 toxicity in 58% of patients. Febrile neutropenia developed in seven patients. Nonhematologic toxicity consisted mainly of neuropathy (grade 3 in 11 patients and grade 2 in another 27 patients). Conclusion Oxaliplatin combined with the bolus Nordic schedule of FU+FA (Nordic FLOX) is a well-tolerated, effective, and feasible bolus schedule as first-line treatment of metastatic colorectal cancer that yields comparable results compared with more complex schedules.
Prevention of Cardiovascular Disease
Authors: M. F. Graham
Journal: JAMA (1973)

<h3>To the Editor.—</h3> At a recent American Heart Association Conference on Cardiovascular Disease Epidemiology, a commentator on a paper relating to blood pressures in children implied that pediatricians as a group are somewhat remiss when it comes to doing routine blood pressure determinations on their patients. It is unfortunate that such a premise, though unsubstantiated by actual data, is probably valid, and the mere fact that suspicions exist should be disturbing to pediatricians. In a day when cardiovascular disease is the number one health problem confronting our nation, it is equally lamentable to surmise that the average pediatrician does not routinely inquire, even cursorily, into such familial disorders as strokes, hypertension, myocardial disease, diabetes, lipid disorders, and gout; nor is he likely to screen for hyperlipidemias, hyperglycemia, or hyperuricemia when family histories warrant. Pathogenetically speaking, cardiovascular disease is a pediatric disease. Its earliest footprints on aortal intimae appear in early
Letter from Peru: Peru revisited
Authors: H. Veeken
Journal: BMJ (1995)

“Twelve years I have been away from my village, twelve years; that is a long time, you know.” The old man looks at me as if he expects that I cannot grasp the suffering he went through. Maybe I cannot, but the picture speaks for itself. His village, Umaro, had sparkled in the valley when we approached it from the mountain. The descent by car was spectacular, as was the bridge we had to cross by foot. The bridge was made of two cables suspended from one side of the river to the other. Across the wires were planks, but many were missing and, worse, some were so rotten that we dared not tread on them; we had to jump, with the turbulent stream 20 metres below.

The village had once been a prosperous place, but now only remnants of this past, overgrown by weeds, remained. The old man shows us around. “The church has no roof, only the walls stand, but the bell shines in the sun,” he says proudly. “It has been stolen twice, but we retrieved it.”

Umaro, a small village in the middle of the Andes, is an example of the situation faced by returnees. Twelve years ago the residents were forced to leave their village, owing to the attacks of the “terrucos” (terrorists of Sendero Luminoso). “Over 60 of my people have died,” he tells me as we walk on. “After four attacks there was no other way than to leave our village. I moved with my family to Ayacucho, others to Lima or Ica, but we stayed in contact. We always wanted to return; it is not easy to leave your place when you are 70,” he says.

“How long have you been back?” I ask him.

“We returned one year ago,” he answers, …
Mammography Adherence and Psychological Distress Among Women at Risk for Breast Cancer
Authors: C. Lerman, M. Daly, C. Sands, A. Balshem, E. Lustbader, T. Heggan, L. Goldstein, J. James, P. Engstrom
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Mammography Adherence and Psychological Distress Among Women at Risk for Breast Cancer Get access Caryn Lerman, Caryn Lerman Fox Chase Cancer CenterPhiladelphia, Pa Correspondence to: Caryn Lerman, Ph.D., Fox Chase Cancer Center, 510 Township Line Rd., Cheltenham, PA 19012. Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary Daly, Mary Daly Fox Chase Cancer CenterPhiladelphia, Pa Search for other works by this author on: Oxford Academic PubMed Google Scholar Colleen Sands, Colleen Sands Fox Chase Cancer CenterPhiladelphia, Pa Search for other works by this author on: Oxford Academic PubMed Google Scholar Andrew Balshem, Andrew Balshem Fox Chase Cancer CenterPhiladelphia, Pa Search for other works by this author on: Oxford Academic PubMed Google Scholar Edward Lustbader, Edward Lustbader Fox Chase Cancer CenterPhiladelphia, Pa Search for other works by this author on: Oxford Academic PubMed Google Scholar Tracy Heggan, Tracy Heggan Fox Chase Cancer CenterPhiladelphia, Pa Search for other works by this author on: Oxford Academic PubMed Google Scholar Lori Goldstein, Lori Goldstein Fox Chase Cancer CenterPhiladelphia, Pa Search for other works by this author on: Oxford Academic PubMed Google Scholar Joan James, Joan James Fox Chase Cancer CenterPhiladelphia, Pa Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul Engstrom Paul Engstrom Fox Chase Cancer CenterPhiladelphia, Pa * See "Notes" section following "References." Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 13, 7 July 1993, Pages 1074–1080, https://doi.org/10.1093/jnci/85.13.1074 Published: 07 July 1993 Article history Received: 31 December 1992 Revision received: 26 March 1993 Accepted: 08 April 1993 Published: 07 July 1993
Can three incongruence tests predict when data should be combined?
Authors: C. W. Cunningham
Journal: Molecular Biology and Evolution (1997)

Advocates of conditional combination have argued that testing for incongruence between data partitions is an important step in data exploration. Unless the partitions have had distinct histories, as in horizontal gene transfer, incongruence means that one or more data support the wrong phylogeny. This study examines the relationship between incongruence and phylogenetic accuracy using three tests of incongruence. These tests were applied to pairs of mitochondrial DNA data partitions from two well-corroborated vertebrate phylogenies. Of the three tests, the most useful was the incongruence length difference test (ILD, also called the partition homogeneity test). This test distinguished between cases in which combining the data generally improved phylogenetic accuracy (P > 0.01) and cases in which accuracy of the combined data suffered relative to the individual partitions (P < 0.001). In contrast, in several cases, the Templeton and Rodrigo tests detected highly significant incongruence (P < 0.001) even though combining the incongruent partitions actually increased phylogenetic accuracy. All three tests identified cases in which improving the reconstruction model would improve the phylogenetic accuracy of the individual partitions.
Orthotopic Liver Transplantation for Alcoholic Cirrhosis
Authors: Thomas E. Starzl
Journal: JAMA (1988)

Fifteen patients with Laennec's cirrhosis underwent orthotopic liver transplantation between 1963 and the end of 1979. The first eight patients died perioperatively or within two months, but four of the next seven patients had long survival; three are still alive after 11 to 14 years. After the introduction of cyclosporine therapy, 41 more patients with alcoholic cirrhosis were treated with liver transplantation from 1980 to June 1987. The one-year survival is 73.2%, and, after one to three years, 28 (68%) of the recipients are living. Of the 35 patients in the combined old and new series who lived for six months or longer, only two returned to alcohol abuse. Social and vocational rehabilitation has been the rule in these recipients who were selected primarily because of urgency of need, because they or their families insisted on treatment, and because they and their families thereby committed themselves to long-standing programs of alcoholism care.
Cerebral Microbleeds in Lupus Anticoagulant-Hypoprothrombinemia Syndrome
Authors: Ashutosh P. Jadhav, Nima Aghaebrahim, Brian T. Jankowitz, Tudor G. Jovin
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
MORE ON RESIDENCY TRAINING
Authors: SELVAN DAVISON
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 July 1969MORE ON RESIDENCY TRAININGSELVAN DAVISON, M.D., F.A.C.P.SELVAN DAVISON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-1-214 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In these days of confusion and anxious attempts to alter medical school and resident training curricula I have long felt that there is considerable danger of "throwing out the baby with the bath water." In this vein, I found a recent article in your journal (Ann. Intern. Med. 70: 621, 1969) by Dr. William Engstrom very illuminating.I should like to add my strongest support to his views and urge that they be seriously discussed and considered in our councils....Reference1. STEAD EA: The limitations of teaching. Pharos, April, 1969. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SELVAN DAVISON, M.D., F.A.C.P.Affiliations: 6 E. 86th St. New York, N. Y. 10028 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1969Volume 71, Issue 1Page: 214-216KeywordsResidencyVeins ePublished: 1 December 2008 Issue Published: 1 July 1969 PDF downloadLoading ...
Promoting hand washing, stroke prevention, and tobacco control are recognised at BMJ Group award ceremony
Authors: N. Hawkes
Journal: BMJ (2009)

The best in medicine and health care was celebrated in London on 2 April, when 10 exceptional individuals and teams won BMJ Group awards in the inaugural year of the competition to reward excellence.

Identifying best practice—a familiar subject to BMJ readers—was the theme of the evening, which was cosponsored by the Health Foundation, an independent charity that works to improve the quality of health care in the United Kingdom and beyond. Fiona Godlee, editor of the BMJ , said it had been heartening to receive so many impressive nominations and to learn that so much was happening to promote excellence in health care.

Martin Marshall, the Health Foundation’s director of clinical quality, said that he saw the awards as an opportunity to “inspire, motivate, and support people in health care to achieve the highest possible quality.” The foundation was proud to sponsor the awards, said Professor Marshall. “They are a great opportunity to celebrate the expertise and commitment of those who work so hard in the health service to deliver high quality care for patients.”

The comedian, writer, and presenter Sandi Toksvig, who chaired proceedings at the Marriott Hotel in Grosvenor Square, Mayfair, made no such bold claims. She admitted to no expert knowledge of health care but said she had been reading the BMJ to get herself in the right mood. “Boy, is that a scary publication,” she said. “I read one article about the risks of oesophageal cancer from drinking tea in northern Iran. That’s very specific indeed. I’ve decided I’m not drinking tea there again.”

Ten awards were given, culminating in the Lifetime Achievement award, given to Judith Mackay, a leader in the battle to control tobacco and a woman once described by the tobacco industry as “one of the three most dangerous people in the …
A dietary portfolio approach to cholesterol reduction: Combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia
Authors: David J.A. Jenkins, Cyril W.C. Kendall, Dorothea Faulkner, Edward Vidgen, Elke A. Trautwein, Tina L. Parker, Augustine Marchie, George Koumbridis, Karen G. Lapsley, Robert G. Josse, Lawrence A. Leiter, Philip W. Connelly
Journal: Metabolism (2002)
Problem-Oriented Approach to Practice-Reply
Authors: Henry M. Tufo
Journal: JAMA (1977)

In addition to the marked decrease in hospital use, there was concomitant decrease in the use of all services (visits, laboratory, x-ray) during the same years. Since we provided organized ambulatory services, we were not surprised to see a drop in hospital use. However, serial reductions in use and expenditures for ambulatory services of the magnitude described in this publication have not, to our knowledge, been reported. Situational, social, and psychological problems do make up a large percentage of the total problems seen in comprehensive primary care; however, it is unlikely that such decreases in use and expenditures could have been due solely to changes in the approach to caring for these problems. We would agree with Dr Paul that awareness and competency in treating emotional problems is fundamental to both improving the quality of care and controlling expenditures for care. Physicians will vary in their interest and
Combined Thyroxine and Triiodothyronine for Thyroid Replacement Therapy
Authors: S. Taylor, M. Kapur, R. Adie
Journal: BMJ (1970)

Tablets containing 50μg. of thyroxine and 15μg. of triiodothyronine have been used to treat patients with hypothyroidism of varied aetiology. Following total thyroidectomy a daily dose of three tablets—that is, 150μg. of thyroxine and 45μg. of triiodothyronine—maintained patients in a euthyroid state and produced a protein-bound iodine level within the normal range. The preparation is preferable to dried thyroid because of uniformity of activity and speed of action, and when the patient is clinically euthyroid the P.B.I. falls within the normal range.
Characterization of Diesel Exposure and Wheezing in Infants: the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS)
Authors: P.H. Ryan, G.K. LeMasters, P. Biswas, S. Hu, D.I. Bernstein, J. Lockey, M. Villareal, G.K. Khurana Hershey, S. Grinshpun
Journal: Journal of Allergy and Clinical Immunology (2007)
CT CORONARY ANGIOGRAPHY IS FEASIBLE FOR THE ASSESSMENT OF CORONARY ARTERY DISEASE IN CHRONIC DIALYSIS PATIENTS, DESPITE HIGH CALCIUM SCORES
Authors: Maurits Buiten, Mihaly de Bie, Andre Gaasbeek, J.M.J. Boogers, Cornelis Roos, Joanne Schuijf, J. Krol, Anton Rabelink, Jeroen Bax, Martin Schalij, Johan Jukema
Journal: Journal of the American College of Cardiology (2012)
Specificity Spillover at the Hormone Receptor — Exploring Its Role in Human Disease
Authors: Franklin H. Epstein, Judith E. Fradkin, Richard C. Eastman, Maxine A. Lesniak, Jesse Roth
Journal: New England Journal of Medicine (1989)

IN some disease states, one or more manifestations of hormonal excess may be caused by the interaction of one hormone with the receptor for a different hormone. When one receptor is activated by a signal designed for another, the event is termed a "specificity spillover."1 , 2 Such a spillover, or cross reaction, is not random, but occurs between two hormones with a similar structure. The effects observed are determined not by the hormone that is present, but by the receptor that is activated. A given hormone has a primary affinity for its own receptor, but it may also retain an affinity . . .
An animal model of congestive (dilated) cardiomyopathy: dilatation and hypertrophy of the heart in the chronic stage in DBA/2 mice with myocarditis caused by encephalomyocarditis virus.
Authors: A Matsumori, C Kawai
Journal: Circulation (1982)

To investigate whether lesions that develop in the chronic stage of viral myocarditis are similar to those seen in congestive (dilated) cardiomyopathy, we studied myocarditis in inbred strains of DBA/2 mice infected with encephalomyocarditis (EMC) virus. Myocardial necrosis with calcification appeared on day 4. Thereafter, myocardial necrosis became more extensive and mononuclear cell infiltration was evident and was most marked on day 14. On day 90, cellular infiltration had decreased and myocardial fibrosis was prominent. At this stage, the heart weight was significantly greater in the infected mice than in the controls (0.190 +/- 0.028 g vs 0.122 +/- 0.013 g, mean +/- SD) (p less than 0.001) and the cavity dimensions of the left ventricle were larger (1.67 +/- 0.29 mm vs 1.11 +/- 0.20 mm) (p less than 0.001). The diameters of myocardial fibers of the right ventricle, the interventricular septum and the left ventricle were significantly larger than those of the controls (right ventricle, 16.6 +/- 1.8 vs 13.4 +/- 1.5 micrometer; interventricular septum, 17.8 +/- 1.5 vs 13.8 +/- 1.5 micrometer; left ventricle, 19.4 +/- 1.7 vs 14.8 +/- 1.1 micrometer) (p less than 0.001). This study demonstrates that in viral myocarditis in the chronic stage, lesions develop that resemble those seen in congestive cardiomyopathy.