Rheumatic Fever in Children and Adolescents: A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae: I. Description of the Investigative Techniques and of the Population Studied
Authors: HARRISON F. WOOD
Journal: Annals of Internal Medicine (1964)

Article1 February 1964Rheumatic Fever in Children and AdolescentsI. Description of the Investigative Techniques and of the Population StudiedHARRISON F. WOOD, M.D., RITA SIMPSON, B.A., ALVAN R. FEINSTEIN, M.D., ANGELO TARANTA, M.D., ESTHER TURSKY, R.N., GENE STOLLERMAN, M.D., F.A.C.P.HARRISON F. WOOD, M.D., RITA SIMPSON, B.A., ALVAN R. FEINSTEIN, M.D., ANGELO TARANTA, M.D., ESTHER TURSKY, R.N., GENE STOLLERMAN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-6 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis report describes the selection and allocation of patients, the laboratory techniques, and certain related results in a long-term epidemiologic study of prophylaxis against streptococcal infections and recurrences of rheumatic fever. Begun by Irvington House on May 1, 1954, this study has tested three different antistreptococcal agents, with careful statistical design and control, in a population of 431 children and adolescents who had previously had one or more unequivocal attacks of rheumatic fever. Observation of the patients receiving these prophylactic agents was maintained for 5 calendar years and was continued for some of them through a sixth year, ending April...References1. STOLLERMANRUSOFFHIRSCHFELD GHJHI: I. Prophylaxis against group A streptococci in rheumatic fever: Use of single monthly injections of benzathine penicillin G. New Eng. J. Med. 252: 787, 1955. CrossrefMedlineGoogle Scholar2. GAVRINTURSKYALBAMFEINSTEIN JREBAR: Rheumatic fever in children and adolescents: a long-term epidemiologic study of subsequent prophylaxis, streptococcal infections, and clinical sequelae. II. Maintenance and preservation of the population. Ann. Intern. Med. 60: (Feb. Supp.) 18, 1964. LinkGoogle Scholar3. 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RAMMELKAMPWANNAMAKERDENNY CHLWFW: Epidemiology and prevention of rheumatic fever. Bull. NY Acad. Med. 28: 321, 1952. MedlineGoogle Scholar13. RAMMELKAMPHOUSERHAHNWANNAMAKERDENNYECKHARDT CHHBEOLWFWGC: The prevention of rheumatic fever, in Rheumatic Fever. A symposium held at the University of Minnesota on November 29-30 and December 1, 1951, under the sponsorship of the Minnesota Heart Association. Edited by THOMAS, L., University of Minnesota Press, Minneapolis, 1952, 304-315. Google Scholar14. WOODSTOLLERMANFEINSTEINHAASHIRSCHFELDRUSOFFTARANTA HFGHARRCIJA: A controlled study of three methods of prophylaxis against streptococcal infection in a population of rheumatic children. I. Streptococcal infections and recurrences of acute rheumatic fever in the first two years of the study. New Eng. J. Med. 257: 394, 1957. CrossrefMedlineGoogle Scholar15. JOHNSONSTOLLERMANGROSSMANMCCULLOCH EEGHDJH: Streptococcal infections in adolescents and adults after prolonged freedom from rheumatic fever. I. Results of the first three years of the study. New Eng. J. Med. 263: 105, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARRISON F. WOOD, M.D.; RITA SIMPSON, B.A.; ALVAN R. FEINSTEIN, M.D.; ANGELO TARANTA, M.D.; ESTHER TURSKY, R.N.; GENE STOLLERMAN, M.D., F.A.C.P.Affiliations: Irvington-on-Hudson, New YorkFrom Irvington House, Irvington-on-Hudson, New York, and the Department of Pediatrics and Medicine, New York University School of Medicine, New York.This work was supported in part by the National Heart Institute grant H-1595 (C-1-6), American Heart Association, New York Heart Association, Westchester Heart Association, Wyeth Laboratories, Sullivan County Heart Chapter, and the Genesee County Heart Chapter.Part of the work done by Dr. Taranta was during his tenure of an Advanced Research Fellowship of the American Heart Association.Dr. Wood is currently with the Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut. Dr. Feinstein is with the Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut. Dr. Stollerman is with the Department of Medicine, Northwestern University School of Medicine, Chicago, Illinois.Requests for reprints should be addressed to Harrison F. Wood, M.D., Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven 11, Connecticut. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPoor long-term adherence to secondary penicillin prophylaxis in children with history of rheumatic feverEnzyme-linked immunosorbent assay for group A Streptococcal anti-DNase B in human sera, using recombinant proteins - Comparison to the DNA methyl green micromethodRheumatic Fever and Rheumatic Heart DiseaseAdherence to Medications: Insights Arising from Studies on the Unreliable Link Between Prescribed and Actual Drug Dosing HistoriesDrug ReactionsA pilot study of penicillin prophylaxis for neuropsychiatric exacerbations triggered by streptococcal infectionsWhy has Patient Compliance become Important?REFERENCESHEART: Prophylaxis in Rheumatic and Nonrheumatic Mitral InsufficiencyStreptococcal Infections—The Pharmacist's ResponsibilitiesLong-Term Prognosis of Rheumatic Fever Patients Receiving Regular Intramuscular Benzathine PenicillinThe Role of Tonsils in Predisposing to Streptococcal Infections and Recurrences of Rheumatic FeverRheumatic Fever in SiblingsClinical effects of recurrent attacks of acute rheumatic fever: a prospective epidemiologic study of 105 episodesRheumatic Fever in Children and Adolescents A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae II. Maintenance and Preservation of the PopulationJOSEPH B. GAVRIN, M.S.W., ESTHER TURSKY, R.N., BERTHA ALBAM, M.S.W., ALVAN R. FEINSTEIN, M.D.Rheumatic Fever in Children and Adolescents A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae III. Comparative Effectiveness of Three Prophylaxis Regimens in Preventing Streptococcal Infections and Rheumatic RecurrencesHARRISON F. WOOD, M.D., ALVAN R. FEINSTEIN, M.D., ANGELO TARANTA, M.D., JEANNE A. EPSTEIN, M.D., RITA SIMPSON, B.A.Rheumatic Fever in Children and Adolescents A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae IV. Relation of the Rheumatic Fever Recurrence Rate per Streptococcal Infection to the Titers of Streptococcal AntibodiesANGELO TARANTA, M.D., HARRISON F. WOOD, M.D., ALVAN R. FEINSTEIN, M.D., RITA SIMPSON, B.A., EDITH KLEINBERG, B.S.Rheumatic Fever in Children and Adolescents A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae V. Relation of the Rheumatic Fever Recurrence Rate per Streptococcal Infection to Pre-existing Clinical Features of the PatientsANGELO TARANTA, M.D., EDITH KLEINBERG, B.S., ALVAN R. FEINSTEIN, M.D., HARRISON F. WOOD, M.D., ESTHER TURSKY, R.N., RITA SIMPSON, B.A.Rheumatic Fever in Children and Adolescents A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae VI. Clinical Features of Streptococcal Infections and Rheumatic RecurrencesALVAN R. FEINSTEIN, M.D., MARIO SPAGNUOLO, M.D., HARRISON F. WOOD, M.D., ANGELO TARANTA, M.D., ESTHER TURSKY, R.N., EDITH KLEINBERG, B.S.Rheumatic Fever in Children and Adolescents A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae VII. Cardiac Changes and SequelaeALVAN R. FEINSTEIN, M.D., HARRISON F. WOOD, M.D., MARIO SPAGNUOLO, M.D., ANGELO TARANTA, M.D., SARAN JONAS, M.D., EDITH KLEINBERG, B.S., ESTHER TURSKY, R.N. 1 February 1964Volume 60, Issue 2_Part_2Page: 6-17KeywordsAdolescentsChildrenEpidemiologyFellowshipsHeartPediatricsProphylaxisRheumatic feverStreptococcal infections ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...