Encephalitis Associated with Herpes Simplex Virus
Authors: WILLIAM E. RAWLS
Journal: Annals of Internal Medicine (1966)

Article1 January 1966Encephalitis Associated with Herpes Simplex VirusWILLIAM E. RAWLS, M.D., PETER J. DYCK, M.D., DONALD W. KLASS, M.D., HUGH D. GREER III, M.D., ERNEST C. HERRMANN JR., PH.D.WILLIAM E. RAWLS, M.D., PETER J. DYCK, M.D., DONALD W. KLASS, M.D., HUGH D. GREER III, M.D., ERNEST C. HERRMANN JR., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-104 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFive patients with fatal encephalitis have come under our observation in a 2-year period. Herpes simplex virus was isolated from the brain in all of these cases. The neurologic picture could be separated into those features common to encephalitis and features related to focal cerebral hemisphere disturbance. The nonspecific symptoms consisted of headache, fever, nuchal rigidity, delirium, and coma. Focal seizures, hemiparesis, aphasia, conjugate eye deviation, and focal electroencephalographic (EEG) and angiographic abnormalities indicated a more focal involvement of the cerebral hemisphere. These focal features in the presence of central nervous system infection made the distinction from cerebral abscess difficult....References1. MEYERJOHNSONCRAWFORDDASCOMBROGERS HMRTIPHENG: Central nervous system syndromes of "viral" etiology: a study of 713 cases. Amer. J. Med. 29: 334, 1960. CrossrefMedlineGoogle Scholar2. SMITHLENNETTEREAMES MGEHHR: Isolation of the virus of herpes simplex and the demonstration of intranuclear inclusions in a case of acute encephalitis. Amer. J. Path. 17: 55, 1941. MedlineGoogle Scholar3. ZARAFONETISSMADELADAMSHAYMAKER CJJEJWW: Fatal herpes simplex encephalitis in man. Amer. J. Path. 20: 429, 1944. MedlineGoogle Scholar4. WHITMANWALLWARREN LMJJ: Herpes simplex encephalitis: a report of two fatal cases. JAMA 131: 1408, 1946. CrossrefMedlineGoogle Scholar5. FASTIERALEXANDER LBWS: The isolation of herpes virus from a fatal case of encephalitis. New Zeal. Med. J. 49: 566, 1950. MedlineGoogle Scholar6. LITTLEAKIN SCJM: Meningoencephalitis due to virus of herpes simplex: report of case. J. Med. Ass. Alabama 20: 115, 1950. Google Scholar7. GINDERWHORTON DRCM: Herpes simplex encephalitis. J. Pediat. 39: 298, 1951. CrossrefMedlineGoogle Scholar8. DRAHEIMDE RODANICHE JHE: Herpes simplex encephalitis: report of a case. Amer. J. Clin. Path. 22: 1077, 1952. CrossrefMedlineGoogle Scholar9. PEARSONBUTT HEEM: Hemorrhagic herpetic encephalitis. Amer. J. Clin. Path. 26: 1174, 1956. CrossrefMedlineGoogle Scholar10. HAYMAKERSMITHVAN BOGAERTDE CHENAR WMGLC: Pathology of viral disease in man characterized by nuclear inclusions: with emphasis on herpes simplex and subacute inclusion encephalitis, in Viral Encephalitis: A Symposium. Fifth Annual Scientific Meeting of the Houston Neurological Society Texas Medical Center, Houston, Texas, edited by FIELDS, W. S., BLATTNER, R. J. Charles C Thomas, Publisher, Springfield, Ill., 1958, pp. 95-201. Google Scholar11. KERENYIFAULKENERPETITE NRE: Herpes simplex encephalitis: a fatal case. Canad. Med. Ass. J. 81: 1011, 1959. MedlineGoogle Scholar12. PAVRIJADHAVWEBBGEORGE KMJKS: Herpes simplex encephalitis: isolation of virus from a fatal case in south India. Indian J. Med. Res. 51: 223, 1963. MedlineGoogle Scholar13. MACCALLUMPOTTEREDWARD FOJMDH: Early diagnosis of herpes-simplex encephalitis by brain biopsy. Lancet 2: 332, 1964. CrossrefMedlineGoogle Scholar14. PIERCEPORTNOYLEEDSMORRISONWEHRLE NFBNERLPF: Encephalitis associated with herpes simplex infection presenting as a temporal-lobe mass: report of 2 cases with survival. Neurology 14: 708, 1964. CrossrefMedlineGoogle Scholar15. DRACHMANADAMS DARD: Herpes simplex and acute inclusion-body encephalitis. Arch. Neurol. (Chicago) 7: 45, 1962. CrossrefMedlineGoogle Scholar16. SCHNELLDYCKBOWIEKLASSTASWELL RGPJEJDWHF: Infectious mononucleosis: neurologic and EEG findings. Unpublished data. Google Scholar17. ROVITSIGLER RLMH: Hyponatremia with herpes simplex encephalitis: possible relationship of limbic lesions and ADH secretion. Arch. Neurol. (Chicago) 10: 595, 1964. CrossrefMedlineGoogle Scholar18. RADERMECKER J: Systématique et électroen-céphalographie des encéphalites et encéphalopathies. Electroenceph. Clin. Neurophysiol. Supplement 5: 1956, 239 pp. Google Scholar19. BORNSTEINSER BI: Epileptiforme Anfälle bei Herpes simplex recidivans. Confin. Neurol. 14: 1, 1954. CrossrefMedlineGoogle Scholar20. CHATRIANSHAWLEFFMAN GECH: The significance of periodic lateralized epileptiform discharges in EEG: an electrographic, clinical and pathological study. Electroenceph. Clin. Neurophysiol. 17: 177, 1964. CrossrefGoogle Scholar21. SCOTT TF: The herpes virus group, in Viral and Rickettsial Infections of Man, 3rd ed., edited by RIVERS, T. M., HORSFALL, F. L., JR. J. B. Lippincott Co., Philadelphia, 1959, pp. 757-772. Google Scholar22. BURNETWILLIAMS FMSW: Herpes simplex: a new point of view. Med. J. Aust. 1: 637, 1939. CrossrefGoogle Scholar23. WHITE JG: Fulminating infections with herpes-simplex virus in premature and newborn infants. New Eng. J. Med. 269: 455, 1963. CrossrefMedlineGoogle Scholar24. BECKERNAUDÉKIPPSMCKENZIE WWTAD: Virus studies in disseminated herpes simplex infections: association with malnutrition in children. S. Afr. Med. J. 37: 74, 1963. MedlineGoogle Scholar25. JOHNSON RT: The pathogenesis of herpes virus encephalitis. I. Virus pathways to the nervous system of suckling mice demonstrated by fluorescent antibody staining. J. Exp. Med. 119: 343, 1964. CrossrefMedlineGoogle Scholar26. SCHMIDTRASMUSSEN JRAF: Activation of latent herpes simplex encephalitis by chemical means. J. Infect. Dis. 106: 154, 1960. CrossrefMedlineGoogle Scholar27. SHEARERFINCH MLSM: Periodic organic psychosis associated with recurrent herpes simplex. New Eng. J. Med. 271: 494, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM E. RAWLS, M.D.; PETER J. DYCK, M.D.; DONALD W. KLASS, M.D.; HUGH D. GREERIII, M.D.; ERNEST C. HERRMANNJR., PH.D.Affiliations: Rochester, MinnesotaFrom the Sections of Medicine, Neurology, Physiology, and Microbiology, Mayo Clinic and Mayo Foundation, Rochester, Minn.Dr. Rawls is presently Public Health Research Fellow, Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Tex.Requests for reprints should be addressed to Section of Publications, Mayo Clinic, Rochester, Minn. 55902. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDistinguishing Features Common to Dual Fatal Herpes Simplex Virus Infections That Occur in Both a Pregnant Woman and Her Newborn InfantMolecular analysis of clinical isolates of acyclovir resistant herpes simplex virusHERPES SIMPLEX VIRUS ENCEPHALITIS IN PREGNANCYEEG and pathologic findings in patients undergoing brain biopsy for suspected encephalitisVerlauf und Therapie der viralen MeningoenzephalitisRecent Developments in Antiviral ChemotherapyEarly diagnosis of herpes simplex encephalitis in childhoodTrial with Human Leucocyte Interferon and Vidarabine in Herpes Simplex Virus Encephalitis: Diagnostic and Therapeutic ProblemsAcute EncephalitisPara-infectious encephalopathies in childhood EEG-aspects and familial occurrenceHerpesvirus hominisHerpes simplex encephalitis in pregnancyDiagnosis of viral disease and the advent of antiviral drugsImmunofluorescence staining for the diagnosis of herpes encephalitisHerpes- und verwandte VirenPeriodic complexes in herpes simplex encephalitis. A clinical and experimental studyThe clinical features of herpes simplex encephalitis (acute necrotizing encephalitis)Herpes Simplex Encephalitis: A light and electron microscopic study in a fatal casePsychopathologie der Encephalitis vom temporalen TypAcute Viral EncephalitisIsotope encephalography in the management of acute herpesvirus encephalitisTHE ELECTROENCEPHALOGRAM IN HERPES-SIMPLEX ENCEPHALITISOn the Role of Viruses in Acute Infectious Diseases of the Central Nervous System: Clinical and Laboratory Studies on Hospitalized PatientsThree Suspected Cases of Herpes Simplex Virus EncephalitisViral infections of the skin and mouth: A selected reviewDiagnosis and treatment of herpes encephalitisHerpetic infection in adultsTHE EFFECT OF IODO-DEOXYURIDINE ON HERPES SIMPLEX VIRUS ENCEPHALITIS IN ANIMALS AND MANELECTROENCEPHALOGRAPHY IN DIAGNOSIS OF HERPES-SIMPLEX ENCEPHALITISHerpes encephalitisENCEPHALITISEncephalitis in the Newborn Pup due to a Canine HerpesvirusHerpes simplex encephalitis: Brain biopsy andtreatment with 5-iodo-2′-deoxyuridineHerpesvirus Infections of the Human Central Nervous SystemNeurosurgical Experiences with Herpes Simplex EncephalitisExperimental herpes simplex encephalitis Electroencephalographic, clinical, virologic, and pathologic observations in the rabbitBrain scan in a patient with herpes simplex encephalitisPLUGGING A PERSISTENT DUCTUSACUTE NECROTISING ENCEPHALITISViral Diseases of the Nervous SystemAcute necrotizing encephalitis: a problem in diagnosis.The neuropathological aspects of acute encephalomyelitis 1 January 1966Volume 64, Issue 1Page: 104-115KeywordsComaElectroencephalographyEncephalitisEpileptic seizuresHeadachesHerpes simplexMicrobiologyNeurologyPrevention, policy, and public healthVirology ePublished: 1 December 2008 Issue Published: 1 January 1966 PDF downloadLoading ...