Thyrotrophin Radioimmunoassay: Another Test of Thyroid Function
Authors: ROBERT D. UTIGER
Journal: Annals of Internal Medicine (1971)

Editorials1 April 1971Thyrotrophin Radioimmunoassay: Another Test of Thyroid FunctionROBERT D. UTIGER, M.D.ROBERT D. UTIGER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-4-627 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe two concepts that secretion of thyrotrophin (TSH) from the pituitary is a major determinant of thyroid secretion and that the circulating thyroid hormone concentration in turn regulates TSH secretion have been well established for many years. An additional hormonal determinant of TSH secretion is the hypothalamic factor, thyrotrophin-releasing hormone (TRH). Nevertheless, only recently, with the application of the highly sensitive and specific radioimmunoassay method to the measurement of TSH in plasma or serum, has it been possible to assess quantitatively the role of TSH in the maintenance of thyroid secretion and the effect of thyroid hormones or other factors...References1. ODELLWILBERUTIGER WJR: Studies of thyrotropin physiology by means of radioimmunoassay. Recent Progr Hormone Res 23:47-85, 1967 MedlineGoogle Scholar2. UTIGER R: Thyrotropin in blood, in Clinical Endocrinology 11, edited by ASTWOOD E, CASSIDY C. New York, Grune & Stratton, Inc. 1968, pp. 25-39 Google Scholar3. RAUDODELL HW: The radioimmunoassay of human thyrotropin. Brit J Hosp Med 2:1366-1374, 1969 Google Scholar4. NICOLOFFFISHERAPPLEMAN JDM: The role of glucocorticoids in the regulation of thyroid function in man. J Clin Invest 49:1922-1929, 1970 CrossrefMedlineGoogle Scholar5. WILBERUTIGER JR: The effect of glucocorticoids on thyrotropin secretion. 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ADAMSKENNEDYUTIGER DTR: Serum thyrotropin concentrations: measurements by bioassay and immunoassay in iodine deficiency and other states, in Proceedings of the VI International Thyroid Congress, Vienna, June 1970 Google Scholar11. GLATSTEINELTRINGHAMKRISS EJJ: Serum TSH and thyroid function following x-ray therapy in patients with malignant lymphoma (abstract). Clin Res 18:168, 1970 Google Scholar12. FLEISCHERBURGUSVALE NRW: Preliminary observations on the effect of synthetic thyrotropin releasing factor on plasma thyrotropin levels in man. J Clin Endocr 31:109-112, 1970 CrossrefGoogle Scholar13. HALLAMOSGARRY RLR: Thyroid stimulating hormone response to synthetic thyrotropin releasing-hormone in man. Brit Med J 2:274-277, 1970 CrossrefMedlineGoogle Scholar14. HERSHMANPITTMAN JJ: Response to synthetic thyrotropin-releasing hormone in man. J Clin Endocr 31:457-460, 1970 CrossrefMedlineGoogle Scholar15. HAMILTONADAMSMALOOF CLF: Hyperthyroidism due to thyrotropin-producing pituitary chromophobe adenoma. New Eng J Med 283:1077-1080, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Pennsylvania School of Medicine Philadelphia, Pa. 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