tbuckley/cabot-search huggingface dataset:
Abstract 4880: CASZ1, a neuroblastoma tumor suppressor gene, is epigenetically silenced by EZH2
Authors: Chunxi Wang, Chanwook Woo, Zhihui Liu, Jun Wei, Young Song, Lifeng Wang, Javed Khan, Kai Ge, Carol J. Thiele
Journal: Cancer Research (2010)

Abstract Casz1 is a C2H2 Zn-finger transcriptional factor that localizes to a region of LOH on Chr1p36.22 in tumors of Neuroblastoma patients who have a poor prognosis. Moreover, high CASZ1 expression is found in tumors of patients with a good prognosis while tumors from patients with a poor prognosis express low levels of CASZ1 (58 patients, p= 2.07×10-6). Studies indicate that CASZ1 functions as a tumor suppressor gene. Our finding that treatment of NB cells with HDAC inhibitors results in a 10-fold increase in CASZ1 expression suggests that epigenetic silencing contributes to the functional loss of CASZ1 expression from the remaining Chr1p36.22 allele. In studying the mechanism of CASZ1 epigenetic silencing, we found a bivalent chromatin modification region around the CASZ1 Transcription Start Site (TSS) that contains both a H3K27 methylation mark as well as an H3K4 methylation mark. The H3K27 methylation is thought to be a gene repressive marker, which is catalyzed by Polycomb repressor complex 2 (PRC2) proteins. PRC2 contains three core components, EZH2, EED and SUZ12, in which EZH2 (enhancer of zeste 2) is a methyltransferase catalyzing H3K27 methylation. Using Chromatin Immunoprecipitation (ChIP) we identified a 5-fold decrease in binding of EZH2, EED and SUZ12 to the bivalent region after HDAC inhibitor treatment. Consistent with decreased PRC2 binding is the finding of decreased tri-methylation of H3K27 and an increase in H3K4me3, a histone mark associated with transcriptionally active genes. The changes in histone modifications are associated with the activation of the CASZ1 gene. RNA silencing of EZH2 also leads to increases in CASZ1 expression. Consistent with this, CASZ1 expression is also up-regulated (3- fold) in EZH2 knockout MEFs compared to EZH2 wild type MEFs. This indicates that CASZ1 expression on the remaining allele is silenced by epigenetic modifications mediated by EZH2. High expression of EZH2 and EED are also found in tumor samples of neuroblastoma patients with a poor prognosis (58 patients, p=2.6×10-3 for EED and p=5.87×10-4 for EZH2). This is consistent with a model in which aberrant epigenetic gene silencing of the tumor suppressor gene CASZ1 contributes to neuroblastoma tumorigenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4880.
ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT
Authors: C CECONI, K FOX, W REMME, M SIMOONS, M BERTRAND, G PARRINELLO, C KLUFT, A BLANN, D COKKINOS, R FERRARI
Journal: Cardiovascular Research (2006)

EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease [EUROPA] demonstrates reduction in cardiovascular mortality and myocardial infarction for a possible vascular and antiatherosclerotic effect of angiotensin-converting enzyme (ACE) inhibition with perindopril. Our objective was to study the effect of perindopril on endothelial function and to verify its link to risk and occurrence of cardiovascular events.Blood from 1200 EUROPA patients was withdrawn at baseline and after 1 year of treatment with either perindopril or placebo to measure von Willebrand factor and from 45 healthy subjects and 87 EUROPA patients to study endothelial function at the cellular level by cultivating in vitro human umbilical vein endothelial cells. In this setting, we determined protein expression/activity of endothelial nitric oxide synthase and the rate of apoptosis. Plasma levels of angiotensin II, bradykinin, tumor necrosis factor alpha, and nitrite/nitrate were also measured.The occurrence of cardiovascular events was related to von Willebrand factor at baseline (P = 0.013) that also significantly decreased after 1 year's treatment (P < 0.001). Perindopril upregulated 19% and 27% protein expression/activity of endothelial nitric oxide synthase (P < 0.05) as well as reduced the rate of apoptosis by 31% (P < 0.05). There was also a significant reduction in levels of angiotensin II, increase in bradykinin, reduction in tumor necrosis factor alpha, and increase in nitrite/nitrate (P < 0.05 for all).Abnormal endothelial function occurs in patients with coronary artery disease, and this can be counteracted by angiotensin-converting enzyme inhibition with perindopril. These effects could contribute, at least in part, to explaining the results of the main EUROPA Study.
Successful Treatment of Fetal Congestive Heart Failure Secondary to Tachycardia
Authors: John T. Harrigan, John J. Kangos, Anju Sikka, Kenneth R. Spisso, Narayanan Natarajan, David Rosenfeld, Sherwin Leiman, Donald Korn
Journal: New England Journal of Medicine (1981)

FETAL cardiac arrhythmia is being detected with increasing frequency as a result of continuous electronic monitoring of the fetal heart rate. Most of these cases have been recognized during labor, and a few have been identified during the early antepartum period.1 2 3 4 5 6 Most fetal cardiac arrhythmias have had a favorable outcome,2 3 4 but among the reported adverse neonatal sequelae is persistence of a supraventricular tachycardia in the newborn with or without subsequent congestive heart failure.2 , 5 , 7 We report a case of fetal tachycardia in which congestive heart failure developed in utero. The problem was identified at 26 weeks' gestation and treated successfully by . . .
Abstract 1368: Genome-wide screening of DNA methylation markers to predict the presence of lymph node metastasis in esophageal squamous cell carcinoma
Authors: Ken-ichi Kozaki, Hiroaki Nagata, Kousuke Tanimoto, Naoto Fujiwara, Seiya Imoto, Daisuke Ichikawa, Satoru Miyano, Tatsuyuki Kawano, Eigo Otsuji, Johji Inazawa
Journal: Cancer Research (2014)

Abstract Lymph node metastasis (LNM) of esophageal squamous cell carcinoma (ESCC) is well-known to be an early event that is associated with poor prognosis of ESCC patients. In the last few years, tumor-specific aberrations in DNA methylation of CpG islands around promoter regions of tumor-related genes have been investigated as possible biomarkers for early diagnosis, treatment and prognosis of human cancers. But, there are few DNA methylation markers that can predict the presence of LNM in patients with ESCC. To identify DNA methylation markers correlated with LNM of ESCC, we performed a genome-wide screening of DNA methylation status in a discovery cohort of 67 primary ESCC tissues and their paired normal esophageal tissues by Illumina Infinium HumanMethylation450 BeadChip (covers more than 450,000 CpG sites). In this screening, we focused on some differentially methylated regions (DMRs), which were significantly associated with LNM of ESCC, as prime candidates for DNA methylation markers. In addition, these significant relationships were also confirmed by quantitative bisulfite pyrosequencing analysis in the same discovery cohort. Consequently, these results led us to consider that our selected DMRs might be useful epigenetic biomarkers for the prediction of the presence of LNM in primary ESCC cases. Therefore, we are continuing further analyses of these DMRs in an independent external validation cohort of ESCC patients. Citation Format: Ken-ichi Kozaki, Hiroaki Nagata, Kousuke Tanimoto, Naoto Fujiwara, Seiya Imoto, Daisuke Ichikawa, Satoru Miyano, Tatsuyuki Kawano, Eigo Otsuji, Johji Inazawa. Genome-wide screening of DNA methylation markers to predict the presence of lymph node metastasis in esophageal squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1368. doi:10.1158/1538-7445.AM2014-1368
(17) Disseminate and recurrent infundibulo-folliculitis
Authors: C.B. Archer, E. Cronin, F.M. Pope
Journal: British Journal of Dermatology (1985)

Journal Article (17) Disseminate and recurrent infundibulo‐folliculitis Get access C.B. Archer, C.B. Archer ST John's Hospital for Diseases of the Skin, London WC2 Search for other works by this author on: Oxford Academic Google Scholar E. Cronin, E. Cronin ST John's Hospital for Diseases of the Skin, London WC2 Search for other works by this author on: Oxford Academic Google Scholar F.M. Pope F.M. Pope Northwick Park Hospital, Middlesex Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Page 62, https://doi.org/10.1111/j.1365-2133.1985.tb13032.x Published: 01 July 1985
Genital and anorectal mucosal melanoma is associated with cutaneous melanoma in patients and in families
Authors: H. Cazenave, E. Maubec, H. Mohamdi, F. Grange, B. Bressac-de Paillerets, F. Demenais, M.F. Avril
Journal: British Journal of Dermatology (2013)

Journal Article Genital and anorectal mucosal melanoma is associated with cutaneous melanoma in patients and in families Get access H. Cazenave, H. Cazenave Service de Dermatologie APHP Hôpital Bichat Paris France Search for other works by this author on: Oxford Academic Google Scholar E. Maubec, E. Maubec Service de Dermatologie APHP Hôpital Bichat Paris FranceINSERM, UMR946, Genetic Variation and Human Diseases Unit Paris FranceUniversité Paris Diderot, PRES Sorbonne Paris Cité Institut Universitaire d'Hématologie Paris France Correspondence Eve Maubec. E‐mail: eve.maubec@bch.aphp.fr Search for other works by this author on: Oxford Academic Google Scholar H. Mohamdi, H. Mohamdi INSERM, UMR946, Genetic Variation and Human Diseases Unit Paris FranceUniversité Paris Diderot, PRES Sorbonne Paris Cité Institut Universitaire d'Hématologie Paris France Search for other works by this author on: Oxford Academic Google Scholar F. Grange, F. Grange Service de Dermatologie Centre Hospitalier Universitaire Robert Debré Reims France Search for other works by this author on: Oxford Academic Google Scholar B. Bressac‐de Paillerets, B. Bressac‐de Paillerets INSERM, UMR946, Genetic Variation and Human Diseases Unit Paris FranceService de Génétique Département de Biopathologie Institut de Cancérologie Gustave Roussy Villejuif France Search for other works by this author on: Oxford Academic Google Scholar F. Demenais, F. Demenais INSERM, UMR946, Genetic Variation and Human Diseases Unit Paris FranceUniversité Paris Diderot, PRES Sorbonne Paris Cité Institut Universitaire d'Hématologie Paris France Search for other works by this author on: Oxford Academic Google Scholar M.F. Avril M.F. Avril Service de Dermatologie APHP Hôpital Cochin Paris FranceUniversité Paris Descartes Paris France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 169, Issue 3, 1 September 2013, Pages 594–599, https://doi.org/10.1111/bjd.12421 Published: 01 September 2013
Percutaneous Catheterization of the Axillary Vein
Authors: F. H. N. Spracklen, F. Niesche, P. W. Lord, E. M. M. Besterman
Journal: Cardiovascular Research (1967)

A comparatively simple method of catheterizing the “central venous space” and right side of the heart by percutaneous puncture of the axillary vein is described. The method has been attempted in 50 patients. It was successful in 45 cases. No significant complications have occurred in this small series.
Persistence of long, thin chrysotile asbestos fibers in the lungs of rats.
Authors: P G Coin, V L Roggli, A R Brody
Journal: Environmental Health Perspectives (1994)

The distribution of inhaled mineral fibers in the lung determines the site and severity of disease caused by the fibers. Some of our recent work has described the fate of inhaled asbestos fibers in rodents. After a brief inhalation exposure, asbestos fibers are deposited primarily at the first alveolar duct bifurcations, and fibrotic lesions are initiated. These sites of deposition occur as close to the visceral pleura as 220 micron. Several studies have suggested that short fibers are cleared from the lung more efficiently than long ones, and our data support this view. Our laboratory has shown that aerosolized chrysotile fibers longer than 16 microns can be deposited in the peripheral lung parenchyma of rats, and the measured clearance rate of these fibers is not significantly different from zero. Chrysotile, but no amphibole, fibers split longitudinally, so that the number of retained chrysotile fibers > or = 16 microns in length increases over time. We have not observed significant changes in chemical composition of chrysotile fibers up to 30 days post-deposition in the rat. Nor have we observed translocation of chrysotile fibers from the "central" regions of the lung toward the subpleural regions. However, 1 month after a single 3-hr exposure to chrysotile asbestos, the longest, most pathogenic fibers persist throughout the lung parenchyma. These retained fibers have the potential to cause disease in both parenchyma and pleura.
Coffee Intake and Serum Lipids in Men
Authors: Karl F. Weyrauch
Journal: JAMA (1985)

To the Editor.—  In view of the possible effect of coffee creamer on plasma lipoprotein concentrations, I was surprised to find no attempt to quantify creamer intake in the population studied by Williams et al. 1   Perhaps comparison of the data for the drinkers of black coffee and for those using milk, half and half, or nondairy creamer would help clarify this relationship.
Clinical Significance of Tolerant Strains of Staphylococcus aureus in Patients with Endocarditis
Authors: K. R. RAJASHEKARAIAH
Journal: Annals of Internal Medicine (1980)

We have studied 50 cases of endocarditis and 54 cases of bacteremia due to Staphylococcus aureus to ascertain the clinical significance of the newly described phenomenon of tolerance. In 32 of the patients with endocarditis and 35 of those with bacteremia strains were classified as tolerant (minimum bactericidal concentration/minimum inhibitory concentration greater than or equal to 16). Patients with endocarditis due to a tolerant strain responded less favorably than did patients with a sensitive strain. A larger number of patients with a tolerant strain had prolonged fever (58% versus 19%), a higher mean number of complications (1.6 versus 0.73), a greater number of intensive-care unit admissions (66% versus 33%), and a higher mortality (25% versus 11%). In contrast there was no difference in response to therapy in bacteremic patients without endocarditis having sensitive and tolerant strains. We conclude that infection with a tolerant organism adversely influences the outcome of staphylococcal endocarditis.
An Intrapericardial Tumbling Bullet
Authors: Joseph A. Abbott
Journal: JAMA (1973)

<h3>To the Editor.—</h3> A bullet that enters the pericardium usually passes somewhat centrally, entering cardiac muscle or intracardiac chambers and severely damaging the heart.<sup>1-4</sup>Some bullets come to rest within the pericardial space per se, and little, if any, cardiac damage results.<sup>5</sup>A case in which a bullet entered the pericardial space, only minimally traumatizing the myocardial wall, is reported herein. This case was unusual in that the bullet was not anchored by structures adjacent to the pericardium and, thus, frequently changed its position and orientation within the cardiac silhouette. A continuous change in the position of the bullet, observed by fluoroscopy and sequential chest roentgenograms proved to be the diagnostic key to the location of the missile. <h3>Report of a Case.—</h3> A 23-year-old motorcyclist was admitted to the San Francisco General Hospital on Aug 28, 1971, following a Saturday night brawl in which he sustained four gunshot
Shortening of Achilles Reflex Time After Exercise
Authors: Maurice Verdy
Journal: JAMA (1968)

Achilles reflex time (ART) has been advocated for assessing thyroid function in outpatients. The effect of exercise on ART was studied in 20 patients, six of whom were healthy, six were hospitalized for unrelated medical reasons, and eight had hypothyroidism. Control recordings with the subjects at rest were made. Following exercise there was significant shortening of ART in both euthyroid and hypothyroid groups. Shortened ART is significant clinically, since simultaneously prolonged ART of hypothyroid patients is in the normal range.
Riboflavin Status in PUVA Patients
Authors: Daniel N. Sauder
Journal: JAMA (1979)

<h3>To the Editor.—</h3> A recently developed method for controlling psoriasis vulgaris employs a phototoxic chemical, 8-methoxypsoralen and long-wave ultraviolet (UV) light in the A range of 320 to 390 nm.<sup>1</sup>The method is called PUVA (for psoralen and UVA). Equipment for delivering the UVA provides UV light with peak intensity at 360 nm but also emits considerable light of longer wavelengths. The vitamin riboflavin is degraded by light in the 425-nm range.<sup>2</sup>Riboflavin deficiency has been caused in neonates treated with phototherapy (415 to 465 nm) for hyperbilirubinemia.<sup>2</sup>We wondered whether PUVA therapy might also result in riboflavin deficiency. Ten patients with psoriasis who were receiving PUVA therapy had their riboflavin levels assessed by the method of erythrocyte glutathione reductase activity.<sup>3</sup>These patients were receiving 40 mg of 8-methoxypsoralen orally, followed after two hours by whole-body irradiation with UVA (along with the inevitable longer wavelengths of
Organizing Organized Medicine Through a Planning and Development Framework (PADFRAME)
Authors: George Stuehler
Journal: JAMA (1977)

PHYSICIANS must substantially expand their societal role beyond self-regulation. Some physicians and other persons have long recognized this need and have urged organized medicine to action. In his 1970 Shattuck Lecture, Dr C. Rollins Hanlon<sup>1</sup>suggested that the difficult priority decisions that must be made concerning the development of health resources should be made by competent professionals in medicine. He argued that expanded roles for organized medicine and inspired leadership in it not only would enhance public respect for organized medicine, but also would be the essential responses to the new political coalitions forming in the health field. In 1971, Dr George Himler<sup>2</sup>underscored the need for effective participation of organized medicine in the formative phase of a system of health care and identified the need for organized medicine to develop flexibility and toughness in promoting the enlightened self-interest of medicine. However, frustrated with the ability of organized
New Approaches for Inflammatory Bowel Disease
Authors: Faruk Hadziselimovic
Journal: JAMA (1990)

<h3>To the Editor. —</h3> We have read Paul Cotton's excellent review article, "New Approaches May Aid Patients With Inflammatory Bowel Disease,"<sup>1</sup>and we would like to report our preliminary results with interferon alpha-2a (Roferon-A/Roche) for treating children with severe, therapy-refractive inflammatory bowel disease: one girl with ulcerative colitis and two boys with Crohn's disease. The patients have received 3 million U of interferon alpha-2a subcutaneously three times a week for a period of 4 to 6 months. The treatment significantly ameliorated the clinical symptoms in all patients: urgency and bloody diarrhea, as well as abdominal pains after 4 weeks. The girl with ulcerative colitis is now in full remission with normal bowel movements and no bloody diarrhea and has a normal life-style. Both boys with Crohn's disease have gained weight, and their perianal fistulas have healed with their achievement of complete clinical and histological remission. The rationale for treating
The Role of Physicians to Stamp Out Smoking
Authors: William G. Phillips
Journal: JAMA (1991)

To the Editor.—  Dr Escobedo and colleagues 1 have reinforced the sad fact that smoking is indeed a plague of old and young alike. It is ironic that the data in their study, acquired from 18- to 35-year-old respondents, reveal that for many in that age group, tobacco has already become a self-abusing habit. Few doubt or are unaware that tobacco abuse starts for many early in the second decade of life when impressionable minds find consolation in peer acceptance. Taking this one logical step further, what impact can we make to change the status quo? As physicians, we must translate our anger against this epidemic into a united voice that mandates a healthier future for all concerned.  Americans of any age can stop smoking. Over the last quarter century, almost half of all living Americans who ever smoked have quit, and per capita cigarette consumption has fallen every year
Reference values for pulmonary function tests of Japanese-American men aged 71 to 90 years.
Authors: D S Sharp, P L Enright, D Chiu, C M Burchfiel, B L Rodriguez, J D Curb
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Pulmonary function was assessed by spirometry in 3,076 elderly Japanese-American men of the Honolulu Heart Program (HHP) cohort. The assessment was done with a stringent quality assurance program that adhered to American Thoracic Society (ATS) recommendations for spirometry. Less than 6% of the participants were unable to perform three acceptable spirometry maneuvers. A "healthy" subgroup of 528 men between the ages of 71 and 90 yr was identified by excluding almost all smokers and subjects with lung disease and other factors negatively influencing FEV1. Reference equations and normal ranges for FEV1, FVC, and the FEV1/FVC ratio were derived from the healthy group. Use of prediction equations from the Cardiovascular Health Study (CHS) of elderly European-American men consistently overpredicted FVC by 0.3 to 0.4 L and FEV1 by 0.15 L. Men in the HHP were on average 11 cm shorter than those in the CHS. Use of a prediction equation derived from the HHP cohort when the men in the cohort were on average 22.6 yr younger consistently overpredicted FEV1 by 0.2 to 0.3 L. These results underscore the importance of using prediction equations appropriate to the ethnicity, age, and height characteristics of the subjects being studied.
Health Manpower: Numbers, Distribution, Quality
Authors: ROBERT G. PETERSDORF
Journal: Annals of Internal Medicine (1975)

Although the "health care crisis" was thought solvable by simply increasing the number of physicians, this has turned out not to be the case. The major problems in physician manpower are geographic maldistribution with a sparsity of physicians in the rural areas and the inner city and an overproduction of specialists. Certain changes in undergraduate and postgraduate medical education have contributed to this maldistribution. There is good evidence that there is an overproduction of surgeons and of medical subspecialists such as cardiologists. Much of the excess subspecialization can be laid at the foot of graduate training programs. The role of the specialty boards in affecting career choices and with them health manpower is analyzed. Some solutions to solve the geographic and specialty maldistribution problems are suggested. It is clear that more primary care physicians including general internists, family physicians, and pediatricians are needed.