The Effect of Small Doses of Stable Iodine in Patients with Hyperthyroidism
Authors: ROBERT VOLPÉ
Journal: Annals of Internal Medicine (1962)

Article1 April 1962The Effect of Small Doses of Stable Iodine in Patients with HyperthyroidismROBERT VOLPÉ, M.D., F.R.C.P.(C), MACALLISTER W. JOHNSTON, M.D., F.R.C.P.(C)ROBERT VOLPÉ, M.D., F.R.C.P.(C), MACALLISTER W. JOHNSTON, M.D., F.R.C.P.(C)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-577 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe administration of stable iodine to hyperthyroid patients has long been known to produce at least temporary clinical benefit. Iodine was used in the treatment of toxic goiter as early as 1840 by von Basedow (1) and in 1854 by Stokes (2). Although Trousseau (3) disagreed with the earlier enthusiasm, in 1868 he convincingly described the beneficial effect of iodine in hyperthyroidism after he had accidentally prescribed tincture of iodine instead of tincture of digitalis to a hyperthyroid patient. In spite of his success with this case, he continued to look upon iodine as a dangerous drug for this disease....References1. VON BASEDOW CA: Exophthalmos durch Hypertrophie des Zellgewebes in der Augenhoehle. Wschr. Ges. Heilk. 6: 197, 1840. Google Scholar2. STOKES W: Diseases of the Heart and Aorta, Hodges and Smith, Dublin, 1854, p. 278. Google Scholar3. TROUSSEAU A: Lectures on Clinical Medicine, vol. 1, lecture XIX, Exophthalmic goitre of Graves' disease, New Sydenham Society, London, 1868, p. 587. Google Scholar4. CHEADLE WB: Exophthalmic goitre. Report of cases treated with iodine. St. George's Hosp. Rep. 4: 175, 1869. Google Scholar5. CHEADLE WB: Exophthalmic goitre. Report of six cases treated with iodine. St. George's Hosp. Rep. 7: 81, 1875. Google Scholar6. MARINELENHART DC: The pathological anatomy of the human thyroid gland. Arch. Intern. Med. 7: 506, 1911. CrossrefGoogle Scholar7. NEISSER E: Ueber Jodbehandlung bei Thyreotoxikose. Berlin Klin. Wschr. 57: 461, 1920. 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CrossrefMedlineGoogle Scholar37. WOLFFCHAIKOFF JIL: Plasma inorganic iodide as a homeostatic regulator of thyroid function. J. Biol. Chem. 174: 555, 1948. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto,From the Department of Medicine, University of Toronto, The Medical Service, Toronto General Hospital, and the Clinical Investigation Unit, Sunnybrook (D.V.A.) Hospital, Toronto, Canada.Presented at the annual meeting of the Royal College of Physicians and Surgeons of Canada, Toronto, Ontario, Canada, January 18-20, 1962.Supported by grants from the National Research Council of Canada.Requests for reprints should be addressed to Robert Volpé, M.D., Department of Medicine, University of Toronto, Toronto, Canada. 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