Preventing Tetanus in Patients with Wounds
Authors: DAVID W. FRASER
Journal: Annals of Internal Medicine (1976)

Editorials1 January 1976Preventing Tetanus in Patients with WoundsDAVID W. FRASER, M.D.DAVID W. FRASER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-1-95 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo-thirds of recent tetanus cases in this country have followed puncture wounds, lacerations, and crush injuries (1-3). These are the cases that the physician caring for the wounded patient seeks to prevent. Rapid, thorough debridement continues to be of central importance in treating the wound to prevent proliferation ofClostridium tetani. Guidelines for administering passive and active immunization to the injured patient have evolved during the past two decades with our increasing knowledge of the immune response to fluid and adsorbed tetanus toxoid and with the introduction of human tetanus immune globulin. Smith, Laurence, and Evans (4) recently published revised...References1. : Tetanus Surveillance. Report No. 2, 1967, 1 April 1969 Google Scholar2. : Tetanus Surveillance. Report No. 3, 1968-1969, 31 March 1970 Google Scholar3. : Tetanus Surveillance. Report No. 4, 1970-1971, 31 March 1974 Google Scholar4. SMITHLAURENCEEVANS JDD: Prevention of tetanus in the wounded. Br Med J 2:453-455, 1975 CrossrefGoogle Scholar5. : Diphtheria and tetanus toxoids and pertussis vaccine. Morbid Mortal Week Rep 21(25 suppl):5-7, 1972 Google Scholar6. VOLKGOTTSHALLANDERSON VRH: Antigenic response to booster dose of diphtheria and tetanus toxoids. Public Health Rep 77:185-194, 1962 CrossrefMedlineGoogle Scholar7. GOTTLIEBMCLAUGHLINLEVINE SFL: Long-term immunity to tetanus-a statistical evaluation and its clinical implications. Am J Public Health 54:961-971, 1964 CrossrefGoogle Scholar8. IPSEN J: Changes in immunity and antitoxin level immediately after secondary stimulus with tetanus toxoid in rabbits. J Immunol 86:50-55, 1961 MedlineGoogle Scholar9. LEVINEMCCOMBDWYER LJR: Active-passive tetanus immunization: choice of toxoid, dose of tetanus immune globulin and timing of injections. N Engl J Med 274:186-190, 1966 CrossrefMedlineGoogle Scholar10. EDSALLELLIOTTPEEBLES GMT: Excessive use of tetanus toxoid boosters. JAMA 202:111-113, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID W. FRASER, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInactivation and Activation of Biologically Active MoleculesLeg ulcersTetanus prophylaxis following ocular injuriesPrinciples of emergency wound managementMisuse of tetanus immunoprophylaxis in wound careThe use of an immunoenzymatic assay for the estimation of tetanus antitoxin in human sera: a comparison with seroneutralization and indirect haemagglutinationTetanus Complicating Elective Surgery Two Cases following Female SterilizationTetanusImmunity to Tetanus in FinlandTetanusTetanusEmergency department treatment, triage and transfer protocols for the burn patientClostridial InfectionsDrugs Spotlight Program Immunization for the InternistDAVID RIMLAND, M.D., JOHN E. McGOWAN Jr., M.D., JONAS A. SHULMAN, M.D. 1 January 1976Volume 84, Issue 1Page: 95-97KeywordsClostridiumGlobulinsImmune responseLacerationsTetanusToxoidsVaccination and immunization ePublished: 1 December 2008 Issue Published: 1 January 1976 PDF downloadLoading ...