tbuckley/cabot-search huggingface dataset:
Prasugrel reduced ischemic outcomes more than did clopidogrel in patients receiving stents for ACS
Authors: William B. Hillegass
Journal: Annals of Internal Medicine (2008)

Source Citation Wiviott SD, Braunwald E, McCabe CH, et al. Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial. Lancet. 2008;371:1353-63. 18377975
The relationship of patient selection to prognosis following aortocoronary bypass.
Authors: M J Conley, A S Wechsler, R W Anderson, H N Oldham, D C Sabiston, R A Rosati
Journal: Circulation (1977)

Operative mortality for the first 787 patients who underwent aortocoronary bypass at Duke University Medical Center was 9.7%. Within 699 patients who underwent elective bypass only, operative mortality was 8.8% before January 1, 1972, and 5.4% subsequently. This apparent variation in operative mortality over time was largely a consequence of changing patterns of patient selection, i.e., a two- to three-fold decrease in the prevalence of ventricular dysfunction. Since January 1, 1972, operative mortality for 444 patients with mild or no heart failure who underwent elective bypass only was 5.0%. The 55 patients with left main disease had 12.7% operative mortality. In the 192 patients without left main disease who had one- or two-vessel disease, operative mortality was 1.0%, whereas, 197 patients with three-vessel disease had a 6.6% operative mortality. The 103 patients with three-vessel disease less than 50 years of age underwent operation with a 2.9% mortality. Although these results demonstrate that selected patients may undergo operation with a mortality approaching 1%, it is not clear that only such low risk patients should be offered surgery. Accurate estimates of benefits and risks of aortocoronary bypass surgery are necessary in the management of specific patients.
Changes in the cervical spine in Association Football players
Authors: O. Sortland, A. T. Tysvaer, O. V. Storli
Journal: British Journal of Sports Medicine (1982)

Forty-three former players for the National Football Team of Norway were examined clinically and radiologically for degenerative changes in the cervical spine. Compared with men of the same age groups the onset of degeneration was 10-20 years earlier and the frequency of degeneration was significantly higher. Degenerative changes were not especially high in “headers”, but this group had a higher frequency of subjective complaints and clinical findings such as reduced cervical movements.
INITIAL LOADING THERAPY OF CILOSTAZOL IMPROVED ANTIPLATELET RESPONSIVENESS IN PATIENT WITH PERCUTANEOUS CORONARY INTERVENTION
Authors: Moo Hyun Kim, Long H. Yu, Jung H. Kim, Sun Y. Park, Tae H. Park, Kwang S. Cha, Young D. Kim, Jin Y. Han
Journal: Journal of the American College of Cardiology (2010)
Diffuse Polyclonal B-Cell Lymphoma during Primary Infection with Epstein–Barr Virus
Authors: James E. Robinson, Nathaniel Brown, Warren Andiman, Karen Halliday, Uta Francke, Marie F. Robert, Maria Andersson-Anvret, Dorothy Horstmann, George Miller
Journal: New England Journal of Medicine (1980)

ALTHOUGH most primary infections with Epstein–Barr virus (EBV) in childhood are silent or associated with mild nonspecific illness, a few are recognized as infectious mononucleosis, a lymphoproliferative disease that is usually self-limited.1 Atypical lymphocytosis, a hallmark of infectious mononucleosis, is largely due to the proliferation of T lymphocytes, which are presumably reactive to EBV-infected lymphocytes in peripheral blood and lymph nodes.2 EBV can induce resting B lymphocytes to proliferate indefinitely in vitro,3 but whether virus–infected cells also proliferate in vivo has remained controversial.4 EBV is found in two types of cancer in human beings, Burkitt's lymphoma and nasopharyngeal carcinoma, which . . .
Glutathione S-Transferase Mu 1 (GSTM1) Gene Associated with Allergic Rhinitis in a Food Allergy Cohort
Authors: Sheva K. Chervinskiy, Lisa Smeester, Michael D. Kulis, David B. Peden, Brian P. Vickery, Rebecca C. Fry
Journal: Journal of Allergy and Clinical Immunology (2015)
Reflections on Medical Journals
Authors: Jerome P. Kassirer
Journal: Annals of Internal Medicine (2002)

Letters17 December 2002Reflections on Medical JournalsJerome P. Kassirer, MDJerome P. Kassirer, MDTufts Univeristy School of Medicine; Boston, MA 02111; Yale University School of Medicine; New Haven, CT 06520Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-12-200212170-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Despite these protestations, achieving transparency by checklist is simply an inadequate substitute for high-quality editing and peer review. The authors' data supporting the use of CONSORT are weak, as they acknowledge openly in the only reference they provide (1). It will take much better evidence than this to convince me that ossifying research reports with checklists and flow charts improves medical care rather than serves the requirements of evidence-based gurus in their aerial palaces of meta-analysis (2).Reference1. Moher D, Jones A, Lepage L. Use of the CONSORT statement and quality of reports of randomized trials: a comparative before-and-after evaluation. JAMA. 2001;285:1992-5. [PMID: 11308436] CrossrefMedlineGoogle Scholar2. Reference not provided. Google Scholar Author, Article, and Disclosure InformationAffiliations: Tufts Univeristy School of Medicine; Boston, MA 02111; Yale University School of Medicine; New Haven, CT 06520 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReflections on Medical Journals: Has Progress Made Them Better? Jerome P. Kassirer Reflections on Medical Journals David Moher , Kenneth F. Schulz , Douglas G. Altman , and Drummond Rennie Metrics 17 December 2002Volume 137, Issue 12Page: 1012KeywordsChartsPeer reviewResearch reporting guidelines ePublished: 17 December 2002 Issue Published: 17 December 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
P2-13-08: A Retrospective Study on Surveillance Behaviour and Prophylaxis after Genetic Testing for Hereditary Breast and Ovarian Cancer among High-Risk Chinese Females.
Authors: A Kwong, ATW Chu
Journal: Cancer Research (2011)

Abstract Background Research in the West has shown that the uptake rates of surveillance and prophylaxis may be different in BRCA mutation carriers and non carriers and this may vary between different ethnicities. To date there is limited comprehensive data available for the behavioural pattern of Asian cohorts. The present on-going study is the first to investigate the behavioural impact and medical compliance of Chinese high risk females who had undergone BRCA1/2 genetic testing up to 1.5 years after genetic testing. Methods: 88 females with personal or family breast and/or ovarian cancer history who had BRCA1/2 genetic testing performed by the Hong Kong Hereditary Breast Cancer Family Registry were surveyed by a face-to-face or telephone interview. Sociodemographic information, genetic test results, pre-and post-testing surveillance practice, chemoprevention methods used and attitudes towards clinical management were obtained. Retrieval of medical records was performed using a prospective database. Results: 39 carriers and 49 noncarriers of a BRCA 1/2 mutations were interviewed. 82.1% of carriers and 79.6% noncarriers had breast and/or ovarian cancer prior to testing. The uptake rate of breast surveillance by eligible carriers (85.2%) and noncarriers (71.1%) remained high after knowing the test results. 12.8% and 15.4% of the eligible carriers had prophylactic contralateral mastectomy and salpingo-oophorectomy respectively, while 5.1% chose to have both procedures within 1.5 years of knowing the genetic test result. Significantly more carriers (85.7%) than noncarriers (49%) underwent ovarian surveillance (p= 0.004). 25.6% of carriers and 26.5% of noncarriers with breast cancer history chose Western chemoprevention methods, while no carriers without breast cancer history chose such methods. 34.7% of carriers (30.8% of noncarriers) used Chinese herbal medicine as complementary prevention treatment after knowing the genetic test result. Clinicians’ advice was perceived as the major reason of choosing a particular surveillance or preventative strategy. Conclusions: As population-based breast screening is unavailable in Hong Kong, the relatively high uptake rate of breast screening among noncarriers may be the result of enhancement in health-consciousness due to prior personal or family cancer experience. Proper education by clinicians is crucial to increase uptake of high risk screening. Traditional Chinese herbal medicine methods are commonly used as a form of prevention. A longitudinal prospective study will contribute to the understanding of attitude-change towards clinical management of this Chinese population who may have different cultural beliefs. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-13-08.
Electromechanical Correlations in Hypertrophic Subaortic Stenosis
Authors: MICHAEL D. KLEIN, VIRENDRA MATHUR, HAROLD D. LEVINE, RICHARD GORLIN
Journal: Circulation (1968)

Six of 14 patients with hemodynamically proven subaortic stenosis (SAS) showed electrocardiographic patterns consistent with myocardial infarction. Analysis of the 0.02-sec horizontal plane vector allowed discrimination between true myocardial infarction and SAS. In SAS this vector was shifted anteriorly and to the right consistent with septal hypertrophy and increased left-to-right early septal forces. Cineangiographic studies of left ventricular contraction revealed a unique pattern also consistent with septal hypertrophy disproportionately greater than that of the ventricular free wall. No correlation existed between maximal instantaneous vectorial voltage, and either the peak left ventricular pressure or the pressure gradient within the left ventricular outflow tract. Striking increases in vectorial forces in SAS may be related to dystrophic changes within the myocardial mass and may not be attributable to simple hypertrophy secondary to hemodynamic obstruction.
Frequencies and patterns of bone marrow involvement in non‐hodgkin lymphomas: Observations on the value of bilateral biopsies
Authors: Barry S. Coller, Bruce A. Chabner, Harvey R. Gralnick
Journal: American Journal of Hematology (1977)

Abstract Pretreatment bone marrow biopsies and aspirations from 85 consecutive patients with non‐Hodgkin lymphoma were reviewed. All patients had at least one adequate biopsy. Criteria for involvement with lymphoma were clearly defined. The frequencies and morphologic patterns of involvement correlated with the lymph node diagnoses assigned according to Rappaport's classification. Diffuse, well‐differentiated lymphocytic and diffuse mixed lymphocytic‐histiocytic lymphoma were most frequently involved (100%), followed by diffuse, poorly differentiated lymphocytic (56%), nodular, poorly differentiated lymphocytic (39%), diffuse undifferentiated (33%), diffuse histiocytic (25%), and nodular mixed lymphocytic‐histiocytic lymphoma (23%). Each of the histologic subtypes tended to have an identifiable pattern of bone marrow involvement. Most striking was a predominance of paratrabecular localization of lymphoma in patients with nodular, poorly differentiated lymphocytic lymphoma. Biopsies were superior to both clot sections and aspirate smears in making the diagnosis of lymphoma in all subtypes, but discrepancies were more common in the nodular than in the diffuse lymphomas. A total of 52 pretreatment bilateral bone marrow biopsies from patients with non‐Hodgkin lymphoma were reviewed for concordance of diagnoses. In five patients, one biopsy was positive for lymphoma while the other was negative. Four of the five patients had histiocytic lymphoma, and the other had nodular mixed lymphoma. In two of these patients the bone marrow examination obviated the need for more invasive procedures to establish stage IV disease. We concluded that bone marrow biopsies are necessary for staging non‐Hodgkin lymphomas and that bilateral biopsies are most useful in the histiocytic subclass.
Adjuvant trastuzumab for breast cancer: Advent of pharmacogenetics raises many issues
Authors: Hazel Thornton
Journal: BMJ (2005)

<h3>Introduction</h3> Acute myocardial infarction (AMI) remains a major cause of mortality and morbidity worldwide despite the latest therapeutic advances designed to decrease myocardial injury. Preclinical and emerging clinical evidence show that the intracoronary injection of autologous bone marrow mononuclear cells (BMCs) following AMI leads to improvement in left ventricular ejection function (LVEF). In this clinical trial we will for the first time assess the effect of early (&lt;24 h) infusion of autologous BMCs following AMI on cardiac function. <h3>Methods and analysis</h3> REGENERATE-AMI is a double-blind, randomised, multicentre, placebo-controlled trial to determine whether early (&lt;24 h) intracoronary infusion of BMCs improves LVEF after AMI. The study will enrol 100 patients presenting with an anterior AMI demonstrating anterior regional wall motion abnormality. Patients will be randomised to receive intracoronary infusion of BMCs or placebo (0.9% saline). Primary endpoint will be change in LVEF at 1 year compared to baseline, measured by cardiac MRI. Secondary endpoints at 6 months include the change in global LVEF relative to baseline measured by quantitative left ventriculography and echocardiography, as well as major adverse cardiac events which is also measured at 1 year. <h3>Ethics and dissemination</h3> The study will be performed in agreement with the Declaration of Helsinki and is approved by local ethics committee (NRES Committee London West London: 07/Q0603/76). <h3>Trial registration</h3> http://clincialtrials.gov (NCT00765453). The results of the trial will be published according to the CONSORT statement and will be presented at conferences and reported in peer-reviewed journals.
Fate mapping of IL-17-producing T cells in inflammatory responses
Authors: Keiji Hirota, João H Duarte, Marc Veldhoen, Eve Hornsby, Ying Li, Daniel J Cua, Helena Ahlfors, Christoph Wilhelm, Mauro Tolaini, Ursula Menzel, Anna Garefalaki, Alexandre J Potocnik, Brigitta Stockinger
Journal: Nature Immunology (2011)
Characterization of benign and malignant melanocytic skin lesions using optical coherence tomography in vivo
Authors: Thilo Gambichler, Philipp Regeniter, Falk G. Bechara, Alexej Orlikov, Remus Vasa, Georg Moussa, Markus Stücker, Peter Altmeyer, Klaus Hoffmann
Journal: Journal of the American Academy of Dermatology (2007)
Clinical Utility of a Multigated Modified Anterior Projection in the Detection of Left Ventricular Inferior and Apical Wall Motion Abnormalities
Authors: JOSEPH F. POLAK, JESUS A. BIANCO, ANDREW J. KEMPER, DONALD E. TOW
Journal: Clinical Nuclear Medicine (1982)

Recent evidence indicates that the left anterior oblique projection (LAO) multigated radionuclide ventriculogram (RVG) underestimates presence and extent of apical and inferior left ventricular (LV) wall motion abnormalities. We investigated, prospectively, the sensitivity and specificity of a modified anterior projection (MAP), which incorporates cephalad tilting. Thirty-three consecutive patients undergoing cardiac catheterization suspected to have coronary artery disease were studied with RVG, using both the MAP and LAO views. LAO views were analyzed using the ejection fraction image (REFI), and the regional ejection fraction (REF) of the inferoapical region. The MAP studies were analyzed using stroke volume image (SVI) to evaluate apical and inferior LV regions. Results were as follows: Both intraobserver and interobserver variabilities were comparable to those of conventional angiographic studies used in detection of apical and inferior asynergy. It is concluded that the multigated MAP offers additional information about abnormalities of the LV inferior and apical regions.
Hypertension in Systemic Necrotizing Vasculitis
Authors: J. L. LEJONC
Journal: Annals of Internal Medicine (1980)

Letters1 July 1980Hypertension in Systemic Necrotizing VasculitisJ. L. LEJONC, M.D., I. MACQUIN, M.D., P. BROCHARD, M.D., A. SCHAEFFER, M.D.J. L. LEJONC, M.D.Search for more papers by this author, I. MACQUIN, M.D.Search for more papers by this author, P. BROCHARD, M.D.Search for more papers by this author, A. SCHAEFFER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-1-150_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Drs. White and Schambelan (1) reported in the February 1980 issue two cases of hypertension with hyperreninemia complicating systemic necrotizing vasculitis. In one case, hypertension was easily controlled with captopril during the time that evidence of healing of renal vasculitis was obtained, likely due to cyclophosphamide and prednisone. Therefore, the authors advocated the use of captopril as an effective antihypertensive agent in such patients. Because hypertension was present, however, in the initial stages of the disease, some degree of hypertension control related to improvement in the underlying disease process cannot be fully ruled out. Indeed, Fauci and...References1. WHITESCHAMBELAN RM. Hypertension, hyperreninemia, and secondary hyperaldosteronism in systemic necrotizing vasculitis. Ann Intern Med. 1980;92(Part 1):199-201. LinkGoogle Scholar2. FAUCIKATZHAYNESWOLFF APBS. Cyclophosphamide therapy of severe systemic necrotizing vasculitis. N Engl J Med. 1979;301:235-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. L. LEJONC, M.D.; I. MACQUIN, M.D.; P. BROCHARD, M.D.; A. SCHAEFFER, M.D.Affiliations: Hôpital Henri Mondor Créteil France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCocaine-associated cerebral vasculitisHypertension and Angiographic Findings in Necrotizing VasculitisRICHARD H. WHITE, M.D., MORRIS SCHAMBELAN, M.D. 1 July 1980Volume 93, Issue 1_Part_1Page: 150-150KeywordsCyclophosphamideHypertensionPatient advocacyVasculitis ePublished: 1 December 2008 Issue Published: 1 July 1980 PDF downloadLoading ...
Mites as Allergens in House Dust
Authors: Richard A. Kern
Journal: JAMA (1970)

To the Editor.—  The Editorial (212: 1514, 1970) on the Mitey Allergen in House Dust, commits the commonest of fallacies in human reasoning: generalization from the particular. That mites constituteanactive, evenanimportant factor involved in house dust sensitivity is an established fact: but not that it istheactive principle of house dusts.  If mites weretheactive principle, thenallpatients sensitive to house dust would react toeveryhouse dust extract that is a proven cause of clinical allergy in a particular patient. This is certainly not the case.  House dusts are obviously conglomerates, with compositions that vary as much as do the people who live in the houses. Different patients may be sensitive to different specific components, and not necessarily to some common components, such as mites, or animal hair (wool) that are present in many or most dusts.  Thus, in my experience, of
The Effect of a Physician Partner Program on Physician Efficiency and Patient Satisfaction
Authors: David B. Reuben, Janine Knudsen, Wendy Senelick, Eve Glazier, Brandon K. Koretz
Journal: JAMA Internal Medicine (2014)

Despite the advantages of electronic health records, concerns have been raised about the amount of computer time spent documenting care1 and its adverse effects on the physician-patient relationship. Using scribes to reduce physician documentation time has resulted in improved satisfaction among urologists2 and increased productivity among Emergency Department physicians3 and cardiologists4. Although scribes have been used in primary care,5 their effects have received little formal evaluation.

We created a new position, a Physician Partner (P2), to facilitate patient care during the office visit and tested this in two practices at an academic medical center to determine its effect upon physician efficiency and patient satisfaction.
P266 Late ventilation is associated with high in-hospital mortality in patients hospitalised with acute exacerbations of COPD
Authors: J. Steer, G. J. Gibson, S. C. Bourke
Journal: Thorax (2011)

<h3>Background</h3> Patients with severe acute exacerbations of COPD (AECOPD) often require treatment with non-invasive ventilation (NIV). The BTS audit reported that patients who develop respiratory acidosis and require NIV after 24 h in hospital have a high mortality risk but this relationship has not been investigated prospectively.1 <h3>Methods</h3> Consecutive patients hospitalised with AECOPD and receiving assisted ventilation (NIV or IPPV) were identified. Demographic information, time from admission to commencement of ventilation, arterial blood gases at admission and at time of development of respiratory acidosis (if different), and outcomes of treatment were recorded. <h3>Results</h3> 195 of 920 patients admitted with AECOPD were initially treated with NIV and four were ventilated invasively. Mean (SD) age was 73.6 (9.8) years, and most: were female (61.4%); had experienced frequent exacerbations in the previous year (median 3, IQR 1–4); were of normal weight (mean (SD) BMI 25.1 (7.0) kg/m<sup>2</sup>); and had severe airflow obstruction (mean (SD) FEV<sub>1</sub> 38.1 (16.1) % predicted). 27.6% of patients had received NIV previously for treatment of AECOPD, and 81 (40.7%) patients had coexistent pneumonia on admission. Median duration of ventilation was 4 days (IQR 1.5–5) and four of the patients who initially received NIV progressed to invasive ventilation. 49 (24.6%) patients died in-hospital. The risk of death increased with longer time from hospital admission to ventilation commencement (Abstract P266 figure 1), with more than 60% of patients who required ventilation after day 2 of their hospital admission not surviving to discharge. <h3>Conclusion</h3> Mortality in AECOPD is particularly high in patients who deteriorate and require ventilation after day 2 of the admission. The time from admission to needing ventilation (NIV or IPPV) should inform clinicians considering the prognosis of patients hospitalised with AECOPD.
Renal Transplantation Update
Authors: RICHARD N. FINE
Journal: Annals of Internal Medicine (1984)

Various factors affect the outcome of renal transplants in humans. Matching for HLA-A, -B, and -DR histocompatibility antigens improves survival rates for renal allografts from first cadaver donors. Zero-HLA-A- and -B-antigen-mismatched grafts and two-HLA-DR-antigen-matched grafts do better, although results differ depending on the recipient's primary renal disease. Pretransplant third-party blood transfusions significantly improve survival rates of cadaver donor allografts. The mechanism of this beneficial effect has not been identified; however, blood transfusions probably do not "select out" high responders among potential recipients by stimulating the production of lymphocytotoxic antibodies. Cyclosporine has been heralded as a potent, nonspecific immunosuppressive agent that will significantly improve renal allograft survival rates. The selectivity of cyclosporine's effect on T lymphocytes is advantageous; however, its side effects, especially nephrotoxicity, may limit its usefulness. Attention to the potential surgical complications of renal transplantation can significantly reduce morbidity and mortality.