tbuckley/cabot-search huggingface dataset:
Obituary Listing
Authors: Douglas Beall
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ANTIDOTAL ACTION OF SODIUM SUCCINATE IN THE MESCALINE PSYCHOSIS
Authors: IAN STEVENSON, ANDREW J. SANCHEZ
Journal: American Journal of Psychiatry (1957)

1. Sodium succinate was found to have a definite antidotal effect on the mescaline psychosis in each of 12 subjects. 2. The effect varied greatly in different subjects. Moreover, the effect was rather transient and there was little shortening of the total duration of mescaline effect. 3. The most plausible hypothesis of the succinate effect is that succinate provides a substrate for oxidation in the brain tissues when the oxidation of other substrates, e.g., glucose, lactate and pyruvate has been depressed by the mescaline.
Cognitive and Behavioural Treatment of Hypochondriasis
Authors: Theo K. Bouman, Sako Visser
Journal: Psychotherapy and Psychosomatics (1998)

&lt;b&gt;Background:&lt;/b&gt; This study investigates the feasibility and effectiveness of time-limited treatment protocols based upon cognitive and behavioural interventions. &lt;b&gt;Method:&lt;/b&gt; Seventeen patients with DSM-IV diagnoses of hypochondriasis were offered 12 1-hour sessions of either ‘pure’ cognitive or ‘pure’ behavioural (i.e. exposure in vivo and response prevention) treatment. Patients were used as their own controls by observing a 4-week period without interventions before and after treatment. &lt;b&gt;Results:&lt;/b&gt; Patients in both treatment conditions improved on specific measures of hypochondriasis (Kellner’s Illness Attitude Scales) and depression. These changes took place during the active treatment period, whereas in the control periods scores remained unchanged. Furthermore, no differential treatment effectiveness could be demonstrated. &lt;b&gt;Conclusions:&lt;/b&gt; Cognitive and behavioural interventions seem to be active ingredients in the treatment of hypochondriasis, although the contribution of nonspecific factors (e.g. patient motivation, therapist attitudes, and the therapeutic relationship) requires further study.
Sequential Uptake Patterns of Technetium-99m Pyrophosphate in Hepatoma
Authors: Shin-Hwa Yeh, Ren-Shyan Liu, Chen-Hui Chuang, Yang-Te Tsai
Journal: Clinical Nuclear Medicine (1985)

Sequential liver scintiphotography with Tc-99m pyrophosphate (PYP) was used to prospectively evaluate its uptake patterns in hepatoma. The scintiphotos and time-activity curves of 40 cases were analyzed. Two distinct patterns of tumor activity were noted: gradual but complete extraction and trapping of Tc-99m PYP in hepatoma in 38% of the patients (group 1), and absence of subsequent Tc-99m PYP uptake in hepatoma after initial blood pool activity in 62% of the patients (group 2). Since extraction and trapping of Tc-99m PYP occur approximately in two fifths of the patients with hepatoma, we conclude that Tc-99m PYP liver scintigraphy is not worthwhile supplementing the conventional radionuclide studies for diagnosing hepatoma, even in the selected patients in the countries where the prevalence of hepatoma is high.
Do Oral Contraceptives Prevent Rheumatoid Arthritis?-Reply
Authors: Deborah J. del Junco
Journal: JAMA (1986)

In Reply.—  To explore the possibility that the lack of a protective effect in our data was a result of serious underascertainment of oral contraceptive use in our control group, we turned to an external standard for comparison, ie, estimates of the percentages of current oral contraceptive use among white, married US females derived from cross-sectional surveys conducted in 1965,1973,1976, and 1982. 1,2 At the time of assessment for oral contraceptive exposure, the range in age for our control population was 17 to 49 years and the range in calendar year was 1960 to 1983. The US data were divided into two age strata (ie, 15 to 29 and 30 to 44 years), which enabled us to compute an  percentage of current oral contraceptive use adjusted (albeit rather crudely) to the age and time-period distribution of our controls. For the entire control group of 182 women, the overall expected
The George Washington Plan
Authors: Thomas M. Peery
Journal: JAMA (1969)

I wish to describe a plan having the same primary objective as the three plans previously presented, but organized entirely within an existing medical school and its related hospitals. Its primary objective is, of course, to increase the output of physicians. This plan is the outgrowth of an observation made in 1958 by our dean, John Parks, MD, that the basic science portion of the medical curriculum is really the limiting factor in the expansion of classes in most medical schools. Most medical schools are located in large cities, which have hospital facilities that are not fully used for undergraduate medical education. Clerkship opportunities can ordinarily be expanded twofold without too much difficulty. By contrast, most basic science departments have no bench space in their teaching laboratories to add a single student. To expand these facilities would, in most instances, require a major building program. And yet the classrooms and
AVOIDANCE OF ANENCEPHALIC AND SPINA BIFIDA BIRTHS BY MATERNAL SERUM-ALPHAFETOPROTEIN SCREENING
Authors: M.A. Ferguson-Smith, H.A. Rawlinson, H.M. May, H.A. Tait, J.D. Vince, A.A.M. Gibson, H.P. Robinson, J.G. Ratcliffe
Journal: The Lancet (1978)
Case 28-1976
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Peter M. Yurchak, John T. Fallon
Journal: New England Journal of Medicine (1976)

Presentation of CaseA nine-year-old girl was admitted to the hospital because of congenital heart disease.She was born of the fifth pregnancy of a mother aged 33 years. At two months of gestation rupture of the spleen occurred after minor abdominal trauma, and the mother underwent splenectomy under spinal anesthesia at another hospital. A postoperative wound infection was treated with unknown antibiotics over an interval of several weeks. Vaginal delivery of a breech presentation was induced two weeks early. There was a transient decrease in the fetal heart rate during delivery, but the child cried spontaneously and appeared active . . .
US survey favours acknowledging medical study ghostwriters
Authors: J. H. Tanne
Journal: BMJ (2009)

Pharma Marketing News , a US online journal, found that three quarters of respondents to a small survey of its readers thought that drug companies’ use of professional writers to write articles for medical journals was acceptable as long as it was clear who wrote the article and who endorsed the content (www.pharma-mkting.com).

John Mack, the journal’s publisher, wrote, “‘Ghostwriting’ in and of itself may not be objectionable, but when sponsored by pharmaceutical companies that distribute medical journal articles on off-label indications to physicians it becomes a huge marketing compliance and ethics concern.”

The US Food and Drug Administration earlier …
Drugs as allergens
Authors: M. A. Smal, B. A. Baldo, D. G. Harle
Journal: Allergy (1988)

The combining site specificities of IgE antibodies that react with the oral antibacterial agent trimethoprim and found in the sera of two subjects who experienced anaphylaxis after taking the drug, were investigated. Hapten inhibition studies with some close analogues of trimethoprim and a range of other structurally related compounds showed that the allergenic determinant complementary to the IgE antibodies in the serum of one of the subjects was the 3,4-dimethoxybenzyl group. The complementary allergenic structure recognized by the IgE antibodies in the serum from the second subject comprised both the trimethoxybenzyl and diaminopyrimidine rings of trimethoprim. Thus, as with thiopentone, but unlike the neuromuscular blocking drugs, the trimethoprim molecule has more than one determinant each with the capacity to provoke IgE formation, interact with the antibody combining site and provoke drug-induced allergic reactions. The general approach set out here employing carefully selected structural analogues in hapten inhibition studies should be invaluable for confirming specificity and identifying allergenic determinants in IgE antibody-mediated allergic drug reactions.
The cellular source of creatine kinase in patients with toxic epidermal necrolysis
Authors: A. Zemtsov
Journal: British Journal of Dermatology (1995)

Journal Article The cellular source of creatine kinase in patients with toxic epidermal necrolysis Get access A. Zemtsov A. Zemtsov Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Ball Memorial Hospital Muncie, IN 47303, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 3, 1 March 1995, Pages 487–488, https://doi.org/10.1111/j.1365-2133.1995.tb08696.x Published: 01 March 1995
Ethical Experimentation In Human Subjects
Authors: Denis Abelson
Journal: JAMA (1967)

To the Editor:—  Much publicity has recently been given to the ethical problems of human experimentation. This, at least, has had the laudable result of making physicians concerned with these matters think carefully before planning even such minor procedures as venipunctures or administration of tracer doses of 131 I in normal subjects. It is therefore particularly shocking to read ( 199 :897, 1967) that, in healthy young college women, about one sixth of the blood volume was removed each week until the hemoglobin concentration remained below 10 gm/100ml.  The inconvenience or harm to which the subjects are exposed cannot be dissociated entirely from the anticipated benefit to the community. Without the inoculation of volunteers with malaria in Australia, our war effort in Southeast Asia would have been largely nullified. With these considerations in mind, I quote from the article in question:  After being made anemic by repeated phlebotomy, the anemia was
Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn’s disease
Authors: Erik J. Schoon, Simona Bollani, Peter R. Mills, Eran Israeli, Dieter Felsenberg, Sverker Ljunghall, Tore Persson, Louise Haptén-White, Hans Graffner, Gabriele Bianchi Porro, Morten Vatn, Reinhold W. Stockbrügger
Journal: Clinical Gastroenterology and Hepatology (2005)
Dermatitis herpetiformis in children: a long‐term follow‐up study
Authors: K. Hervonen, T.T. Salmi, K. Kurppa, K. Kaukinen, P. Collin, T. Reunala
Journal: British Journal of Dermatology (2014)

Journal Article Dermatitis herpetiformis in children: a long‐term follow‐up study Get access K. Hervonen, K. Hervonen Department of Dermatology and Tampere University Hospital PO Box 2000 33521 Tampere FinlandSchool of Medicine andUniversity of Tampere Tampere Finland Search for other works by this author on: Oxford Academic Google Scholar T.T. Salmi, T.T. Salmi Department of Dermatology and Tampere University Hospital PO Box 2000 33521 Tampere FinlandSchool of Medicine andUniversity of Tampere Tampere Finland Search for other works by this author on: Oxford Academic Google Scholar K. Kurppa, K. Kurppa Tampere Center for Child Health Research University of Tampere Tampere Finland Search for other works by this author on: Oxford Academic Google Scholar K. Kaukinen, K. Kaukinen School of Medicine andUniversity of Tampere Tampere FinlandGastroenterology and Alimentary Tract Surgery Tampere University Hospital PO Box 2000 33521 Tampere FinlandDepartment of Medicine Seinäjoki Central Hospital Seinäjoki Finland Search for other works by this author on: Oxford Academic Google Scholar P. Collin, P. Collin Gastroenterology and Alimentary Tract Surgery Tampere University Hospital PO Box 2000 33521 Tampere Finland Search for other works by this author on: Oxford Academic Google Scholar T. Reunala T. Reunala Department of Dermatology and Tampere University Hospital PO Box 2000 33521 Tampere FinlandSchool of Medicine andUniversity of Tampere Tampere Finland Correspondence: Timo Reunala. E‐mail: timo.reunala@uta.fi Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 5, 1 November 2014, Pages 1242–1243, https://doi.org/10.1111/bjd.13047 Published: 01 November 2014
Fatal Hand-Foot-and-Mouth Disease in an Adult Caused by Coxsackievirus A7
Authors: David A. Baker
Journal: JAMA (1979)

HAND-foot-and-mouth disease occurs almost exclusively in children and is usually benign and self-limited. It is caused primarily by coxsackievirus A16,<sup>1</sup>although coxsackieviruses A5, A9, and A10 have also been implicated.<sup>2,3</sup>We recently treated a woman who had classic hand-foot-and-mouth disease, which then progressed to pancarditis and fatal pneumonia. The causative agent was coxsackievirus A7. <h3>Report of a Case</h3> A 29-year-old woman was admitted to the Medical Center Hospital of Vermont with fever, a maculopapular rash on her arms and legs, a sore throat with small vesicles on the pharynx, vesicles on the vaginal mucosa, and abdominal pain. Her illness had begun two days earlier, with pleuritic discomfort exacerbated by deep breathing. The next day a papular rash appeared on her arms and legs. The pleuritic pain worsened, she became febrile, and she noted conjunctival redness. The papular rash had progressed, becoming papulovesicular and involving her thighs, hands, and
Carotid and femoral ultrasound morphology screening and cardiovascular events in low risk subjects: a ten-year follow-up study (the CAFES-CAVE study)
Authors: Lucrezia Incandela, Andrew N. Nicolaides, Maria Teresa De Sanctis, Giovanni Belcaro, Andrea Di Renzo, Ganesh Ramaswami, Maura Griffin, Marco Bucci, Giuseppe Martines, Mike Sabetai, Surinder Dhanjil, Piergiorgio Ferrari, George Geroulakos, Antonio Barsotti
Journal: Journal of the American College of Cardiology (2002)
Erratum to “The influence of BMP-2 and its mode of delivery on the osteoconductivity of implant surfaces during the early phase of osseointegration” [Biomaterials 28 (2007) 2677–2686]
Authors: Yuelian Liu, Lukas Enggist, Alexander F. Kuffer, Daniel Buser, Ernst B. Hunziker
Journal: Biomaterials (2007)
Effects of Dietary Manipulations in Diabetic and Hyperlipidemic Subjects.
Authors: Burt Cochran
Journal: Annals of Internal Medicine (1964)

s1 October 1964Effects of Dietary Manipulations in Diabetic and Hyperlipidemic Subjects.Burt Cochran Jr., M.D., Russell L. Poucher, M.D.Burt Cochran Jr., M.D.Search for more papers by this author, Russell L. Poucher, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-813_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA clinician charged with care of the patient with the combined problems of (1) diabetes mellitus and refractory hyperlipidemia, (2) diabetes mellitus and resistant obesity, or (3) hyperlipidemic xanthomatosis and coronary artery disease may make a choice of several dietary prescriptions. Selected adults with these clinical problems were studied under both hospital and outpatient conditions. Diabetic patients were subjected to the following dietary manipulations: (a) isocaloric and supplemental avocado feeding up to 35% of total calories, (b) total and partial isocaloric substitution of a high polyunsaturated and high total fat formula and (c) total fast (zero caloric intake). Nondiabetic hyperlipidemic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 813-813KeywordsDiabetes mellitusFatsHyperlipidemiaObesityOutpatient clinicsPatientsStable coronary artery disease Issue Published: 1 October 1964 PDF DownloadLoading ...
Predictive Value of Postoperative Glycosuria After Partial Elective Pancreatectomy in Focal Congenital Hyperinsulinism
Authors: Naziha Khen-Dunlop, Carmen Capito, Vassili Valayannopoulos, Caroline Elie, Maria-Joao Ribeiro, Jacques Rahier, Francis Jaubert, Jean-Jacques Robert, Yves Aigrain, Pascale de Lonlay, Claire N. Fékété
Journal: Diabetes Care (2008)

Congenital hyperinsulinism (CHI) is the most frequent cause of persistent hypoglycemia in infants (1). Early diagnosis and management are mandatory to prevent permanent brain damage. Two main forms are distinguished based on anatomical and genetic characteristics: the focal and the diffuse forms (2). In focal forms, the complete removal of the lesion allows the cure of the disease, but residual affected tissue may be left behind. This situation, observed in about 15% of cases, often necessitates additional surgery (3). We evaluated the value of detecting postoperative glycosuria as a predictor of successful surgery for focal CHI.

The study included 51 children operated on for focal …
810 PERCUTANEOUS LASER ABLATION FOR HEARLY-STAGE HEPATOCELLULARCARCINOMA IN SO-CALLED HIGH- RISK LOCATIONS: A RETROSPECTIVE COMPARISON WITH NO HIGH-RISK LOCATIONS LESIONS FOR SAFETY, EFFECTIVENESS AND LONG-TERM OUTCOME
Authors: A. Petrolati, Z. Rossi, C.M. Pacella
Journal: Journal of Hepatology (2009)
Post-vagotomy Diarrhoea: its Cause and Prevention
Authors: H. Burge, P. A. Clark
Journal: BMJ (1959)

A follow-up is presented of cases of x-ray negative haematemesis and/or melaena.Among 142 patients followed up for three to eight years there were 33 (23%) in whom a positive diagnosis was subsequently made and which may have explained the original episode.The diagnoses subsequently made were chronic gastric ulcer in 4, duodenal ulcer in 17, carcinoma of stomach in 4, carcinoma of colon in 3, carcinoma of pancreas in 1, carcinoma of small intestine in 2, Meckel's diverticulum in 1, hereditary haemorrhagic telangiectasia in 1.Among the less common causes special attention is drawn to pseudoxanthoma elasticum, von Willebrand's disease, diverticulosis of the colon, and the Mallory- Weiss syndrome.Aspirin is thought to play a very significant aetiological part.The method of investigation of these cases is discussed in detail.
No More Routine Catheterization for Valvular Heart Disease?
Authors: R.O. Brandenburg
Journal: New England Journal of Medicine (1981)

Should cardiac catheterization continue to be a routine procedure in patients undergoing surgery for valvular heart disease? Since the introduction of valvular heart surgery over three decades ago, the clinical assessment of a patient with valvular heart disease in most institutions has routinely been followed by cardiac catheterization if cardiac surgery has been anticipated. The presentation by Martin St. John Sutton and his associates in this issue of the Journal suggests that routine cardiac catheterization is unnecessary for valve replacement and that the procedure can be reserved for selected situations.1 Their 305 patients, who underwent valve replacement during 1978, were . . .
On the Causes of Pulmonary Consumption
Authors: J. Turnbull
Journal: BMJ (1859)

patient's admission, in consequence cf the pressure to which it had been subjected.A small quiantity of brandy and water was adlministered upon the completion of the operation, and shortly afterwards the following draught:-R Tinctura3 opii aTxxv; retheris ehlorici itxv; aquas Siss.8 P.M. Reaction had taken place in the limb; and the foot was now warmer than the left.The skin was hot; piulse 156.January 28tlh.He had lhad no unfavourable symptoms; pulse 120.The right foot was still the warmer.R Tincturme ferri sesquichloridi nix; aqums 5i.M. Fiat haustus ter die sumendus.January Q29th.He vomited this morning, after taking the iron; but, in other respects, he was doing well.Pulse 106.January :30th.The wound was dressed this morning.It looked healthy; there was a free secretion of laudable pus.The sponges were removed, and the edges of the wound were brought together by long pieces of the water-strapping pretty tightly applied, the, flannel bandaage being replaced as before.February 1 st.The wound was lookinig very healthy.The ligature whliichl was placed on the small artery came away.He was ordered to have some fowl for hiis dinner.Febriaryv 3rd.The lower of the two ligatures placed around the femolal artery came awav this morning; that above was still firm.The wound was looking as healtlhy as coul(d be.February 5th.The ligatture on the proximal end of the artery came away to-day (tenith day).The wound continued to look perfectly lhealthy; the man was gainiing strength and colour, and ate two chops, and took a pint of porter daily.
The "Oily" Paper Bag and Hyperventilation
Authors: David J. Riley
Journal: JAMA (1974)

To the Editor.—  Treating acute psychogenic hyperventilation by rebreathing into a paper bag restores arterial carbon dioxide pressure (PCO2) to normal, and leads to relief of symptoms. We compared the retention of CO2during rebreathing in three different types of bags to determine their clinical usefulness. A plain paper bag, a paraffin-treated (oily) paper bag, and a clear plastic bag of the same size (No. 12) were tested. Bag gas was sampled continuously through a small catheter, and CO2concentration was measured with an infrared CO2analyzer. With the bag held tightly over the mouth and nose, a subject hyperventilated at a constant rate, and the rise in bag CO2was recorded. When the plain paper bag was used, CO2reached a plateau of 43±7 (mean±SD) mm Hg after 15 to 20 breaths. In contrast, CO2rose slightly faster in the oily paper
Published Trials of Nonmedicinal and Noninvasive Therapies for Hip and Knee Osteoarthritis
Authors: David W. Puett
Journal: Annals of Internal Medicine (1994)

To review the efficacy of nonmedicinal, noninvasive therapies in hip and knee osteoarthritis.Search of English-language literature from 1966 through 1993 using MEDLINE by cross-referencing "osteoarthritis" (therapy subheadings) with "controlled trial," "comparative study," or "trial(s)."Fifteen controlled trials of diathermy (deep heat), exercise, acupuncture, transcutaneous electrical nerve stimulation, topically applied capsaicin, low-energy laser, and pulsed electromagnetic fields were found. No experimental studies of superficial heat and cold, orthotic devices, vibration, or weight loss were identified.Exercise reduces pain and improves function in patients with osteoarthritis of the knee. No support exists in the literature for pre-exercise ultrasound treatment. Single, well-designed studies suggest that topically applied capsaicin and laser treatment reduce pain associated with knee osteoarthritis. Data on the other three therapies were sparse (transcutaneous electrical nerve stimulation, pulsed electromagnetic fields) or inconsistent (acupuncture).More data are needed to determine the optimal exercise regimen for treating knee osteoarthritis and to evaluate the role of topical capsaicin, laser therapy, acupuncture, transcutaneous electrical nerve stimulation, and pulsed electromagnetic fields. No data specifically address the role of any of these therapies in hip osteoarthritis.