tbuckley/cabot-search huggingface dataset:
An Evaluation of Clinical and Laboratory Findings in Male Subjects on Long-Term, Low-Fat, Low-Protein Diets
Authors: Cesar A. Caceres, Juan B. Calatayud, Harold H. Orvis, Isa A. Fawal, Raymond Thomas, George A. Kelser, Sidney Abraham, Arthur Anderson
Journal: New England Journal of Medicine (1963)

IN preceding reports1 , 2 data were presented indicating that a group of Trappist monks, subsisting on a diet low in calories, cholesterol, animal fat and protein, did not have serum cholesterol values significantly below those expected for normal males in this country. A second evaluation of the same group was carried out two years later to characterize the serum lipids in these subjects further. The purpose of this paper is to report the additional and composite data and to evaluate the results.Materials and MethodsThirty of 39 previously studied subjects were available for both evaluations. Nine subjects of the original . . .
Response to Letter Regarding Article, “Cardiovascular Death and Nonfatal Myocardial Infarction in Acute Coronary Syndrome Patients Receiving Coronary Stenting Are Predicted by Residual Platelet Reactivity to ADP Detected by a Point-of-Care Assay: A 12-Month Follow-Up”
Authors: Rossella Marcucci, Anna Maria Gori, Rita Paniccia, Betti Giusti, Serafina Valente, Cristina Giglioli, Piergiovanni Buonamici, David Antoniucci, Rosanna Abbate, Gian Franco Gensini
Journal: Circulation (2009)
Could you <i>think</i> Carruthers’ ideas without having to <i>speak</i> them? <i>Talk</i> with yourself if you want to have any <i>thought</i> on that
Authors: Carlos Molina
Journal: Behavioral and Brain Sciences (2002)

First, the importance of language in cognition is recognized. Nevertheless, this does not necessarily imply that the locus of thought is natural language (words, syntax, phonology). Then, difficulties with some of Carruthers’ hypotheses are stated: Is an account based on LFs capable of dealing with the complexities involved in what we call thought? Finally, mention of the issue of language production is made.
An additional heterogeneity hypothesis
Authors: Guy Dove
Journal: Behavioral and Brain Sciences (2010)

Abstract In this commentary, I make three points concerning Machery's response to neo-empiricism. First, his methodological critique fails to remove the threat that neo-empiricism poses to his conceptual eliminativism. Second, evidence suggests that there are multiple semantic codes, some of which are not perceptually based. Third, this representational heterogeneity thwarts neo-empiricism but also raises questions with respect to how we should “do without concepts.”
Extra funds announced to fight cancer in Europe
Authors: R. Watson
Journal: BMJ (2002)

The European Union will spend £400m (£253m; $392m) on cancer research over the next four years, it was announced at a recent one day cancer conference in Brussels.

The move is part of efforts to fight a disease that kills 750000 people in the European Union every year. The funds will be targeted primarily at practical measures designed to break down compartmentalised national systems and help to create a European focus on cancer research.

Announcing details of the new funding, the research commissioner, Philippe Busquin, said …
European group targets overuse of antibiotics
Authors: Rory Watson
Journal: BMJ (2006)

A new pan-European network aimed at addressing the growing problem of resistance to antibiotics used to treat lower respiratory tract infections begins work this week.

The project, which is coordinated by the University of Antwerp in Belgium and funded with a grant of €11.5m (£8m; $14m) from the European Union, brings together partners from 14 countries and involves 13 primary care networks.

Participants in the project, which is called genomics to combat resistance against antibiotics in community acquired lower respiratory tract illness in Europe, or GRACE, have described it as unique, in …
Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts
Authors: Slaven Erceg, Pilar Monfort, Mariluz Hernández‐Viadel, Regina Rodrigo, Carmina Montoliu, Vicente Felipo
Journal: Hepatology (2005)

Patients with liver disease with overt or minimal hepatic encephalopathy show impaired intellectual capacity. The underlying molecular mechanism remains unknown. Rats with portacaval anastomosis or with hyperammonemia without liver failure also show impaired learning ability and impaired function of the glutamate-nitric oxide-cyclic guanine monophosphate (glutamate-NO-cGMP) pathway in brain. We hypothesized that pharmacological manipulation of the pathway in order to increase cGMP content could restore learning ability. We show by in vivo brain microdialysis that chronic oral administration of sildenafil, an inhibitor of the phosphodiesterase that degrades cGMP, normalizes the function of the glutamate-NO-cGMP pathway and extracellular cGMP in brain in vivo in rats with portacaval anastomosis or with hyperammonemia. Moreover, sildenafil restored the ability of rats with hyperammonemia or with portacaval shunts to learn a conditional discrimination task. In conclusion, impairment of learning ability in rats with chronic liver failure or with hyperammonemia is the result of impairment of the glutamate-NO-cGMP pathway. Moreover, chronic treatment with sildenafil normalizes the function of the pathway and restores learning ability in rats with portacaval shunts or with hyperammonemia. Pharmacological manipulation of the pathway may be useful for the clinical treatment of patients with overt or minimal hepatic encephalopathy.
Intestinal Absorption of Hemoglobin Iron-Heme Cleavage by Mucosal Heme Oxygenase
Authors: Steven B. Raffin, Choong H. Woo, Kenneth T. Roost, David C. Price, Rudi Schmid
Journal: Journal of Clinical Investigation (1974)

Hemoglobin and myoglobin are a major source of dietary iron in man. Heme, separated from these hemoproteins by intraluminal proteolysis, is absorbed intact by the intestinal mucosa. The absorbed heme is cleaved in the mucosal cell releasing inorganic iron. Although this mucosal heme-splitting activity initially was ascribed to xanthine oxidase, we investigated the possibility that it is catalyzed by microsomal heme oxygenase, an enzyme which converts heme to bilirubin, CO, and inorganic iron.
THE KOLMER COMPLEMENT FIXATION AS A SPECIFIC TEST FOR SYPHILIS
Authors: F. W. HARTMAN
Journal: JAMA (1924)

The complement fixation test for syphilis, initiated by Wassermann, has been made the subject of such exhaustive investigation and so many thorough statistical studies that it is practically impossible to find any new avenue of approach. Indeed, we find it difficult to say anything of this laboratory procedure without repeating, verbatim, the words of other workers. Lacking certain knowledge of the specific complement binding substances present in the tissues of the syphilitic individual, we cannot yet attain our goal in the diagnosis of syphilis. Facing the fact that antigens prepared from the causative organism are entirely unsatisfactory and that the tissue extract antigens in common use are in no possible way biologically specific; and, further, since the complement binding substance is most abundant at the height of the infection, as opposed to the antibody production in bacterial dis eases, it seems logical to consider the procedure in the light of
Evaluation should have included long term follow up of the mothers
Authors: G. Barrett, C. R Victor
Journal: BMJ (1996)

EDITOR,—We agree with the recommendations in P J Danielian and colleagues' paper and the accompanying editorial that a large randomised controlled trial is required to determine which is the safest and most acceptable mode of delivery in breech presentation at term.1 2 We are concerned, however, that the discussion, particularly in the editorial, does not mention the need for long term follow up of the mother.

The authors …
Impact of JAK2V617F mutation status, allele burden, and clearance after allogeneic stem cell transplantation for myelofibrosis
Authors: Haefaa Alchalby, Anita Badbaran, Tatjana Zabelina, Guido Kobbe, Joachim Hahn, Daniel Wolff, Martin Bornhäuser, Christian Thiede, Herrad Baurmann, Wolfgang Bethge, York Hildebrandt, Ulrike Bacher, Boris Fehse, Axel R. Zander, Nicolaus Kröger
Journal: Blood (2010)
Heart Failure on the Rise
Authors: Rebecca Voelker
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adiponectin regulates albuminuria and podocyte function in mice
Authors: Kumar Sharma, Satish RamachandraRao, Gang Qiu, Hitomi Kataoka Usui, Yanqing Zhu, Stephen R. Dunn, Raogo Ouedraogo, Kelly Hough, Peter McCue, Lawrence Chan, Bonita Falkner, Barry J. Goldstein
Journal: Journal of Clinical Investigation (2008)

Increased albuminuria is associated with obesity and diabetes and is a risk factor for cardiovascular and renal disease. However, the link between early albuminuria and adiposity remains unclear. To determine whether adiponectin, an adipocyte-derived hormone, is a communication signal between adipocytes and the kidney, we performed studies in a cohort of patients at high risk for diabetes and kidney disease as well as in adiponectin-knockout (Ad–/–) mice. Albuminuria had a negative correlation with plasma adiponectin in obese patients, and Ad–/– mice exhibited increased albuminuria and fusion of podocyte foot processes. In cultured podocytes, adiponectin administration was associated with increased activity of AMPK, and both adiponectin and AMPK activation reduced podocyte permeability to albumin and podocyte dysfunction, as evidenced by zona occludens–1 translocation to the membrane. These effects seemed to be caused by reduction of oxidative stress, as adiponectin and AMPK activation both reduced protein levels of the NADPH oxidase Nox4 in podocytes. Ad–/– mice treated with adiponectin exhibited normalization of albuminuria, improvement of podocyte foot process effacement, increased glomerular AMPK activation, and reduced urinary and glomerular markers of oxidant stress. These results suggest that adiponectin is a key regulator of albuminuria, likely acting through the AMPK pathway to modulate oxidant stress in podocytes.
Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions
Authors: A. Tinker, A. R G Lindsay, A. J Williams
Journal: Cardiovascular Research (1993)

Objective: The aim was to perform a theoretical and experimental study of the possible variations in Ca2+ current through the open cardiac sarcoplasmic reticular Ca2+ release channel under the ionic conditions associated with physiological and pathophysiological states. Methods: The sheep cardiac sarcoplasmic reticular Ca2+ release channel was purified and reconstituted into planar phospholipid bilayers for study under voltage clamp conditions. Single channel current-voltage relationships were measured under putative physiological conditions with 1, 5, and 10 mM intraluminal Ca2+. The mathematics of a computer model based on Eyring rate theory were extended to include the interactions of three permeant ions. Results: A model used previously to describe ionic conduction under simpler ionic conditions was able to predict the interaction of Ca2+, Mg2+, and K+ in the probable physiological range over the voltage range of interest. The predicted Ca2+ current under ionic conditions proposed to occur at the end of diastole is sensitive to relatively small changes in holding potential which suggests the need for adequate charge compensation across the sarcoplasmic reticular membrane. Theoretically, it was predicted that variations in intraluminal Ca2+, such as may occur in Ca2+ overload and other conditions, and variations in cytosolic Mg2+, which may occur in myocardial stunning, may significantly affect Ca2+ flux through the open Ca2+ release channel. Conclusions: Variations in permeant ion concentration such as may occur in physiological and pathophysiological states may significantly affect the quantity of Ca2+ released from the cardiac sarcoplasmic reticulum. Cardiovascular Research 1993;27:1820-1825
HLA-DR and tuberculin tests in rheumatoid arthritis and tuberculosis.
Authors: G M Bahr, M A Sattar, J L Stanford, M A Shaaban, B Al Shimali, Z Siddiqui, M Gabriel, M Al Saffar, A Shahin, T D Chugh
Journal: Annals of the Rheumatic Diseases (1989)

Responses to four new tuberculins were found to be significantly reduced in 46 patients with rheumatoid arthritis in comparison with a control group of 79. Except for tuberculin itself, the same was found in 111 patients with tuberculosis. In common with patients with tuberculosis and leprosy, those with rheumatoid arthritis did not respond to common mycobacterial (group i) antigen. Three DR haplotypes were found to have significant effects on skin test responsiveness of the rheumatoid patients but had little or no effect on that of the patients with tuberculosis and none on that of the healthy control group. Rheumatoid patients with the HLA-DR4 haplotype had significantly greater responses to all four reagents than did non-DR4 patients, but their responses to leprosin A and scrofulin remained significantly lower than those of the control group. Possession of HLA-DR3 haplotype was associated with skin test positivity approaching normal, but the sizes of responses were reduced. Possession of DR7 was associated with an unexpected reduction in skin test positivity, especially in the case of tuberculin. These results support the hypothesis that mycobacteria, or autoantigens cross reactive with mycobacteria, may be involved in the aetiology of rheumatoid arthritis. The results also show that the regulation and specificity of responsiveness to mycobacterial antigens are different in patients with rheumatoid arthritis with different HLA-DR haplotypes.
THE USE OF BLOOD-AGAR IN THE ROUTINE EXAMINATION OF MILK SEDIMENTS
Authors: F. W. HACHTEL
Journal: JAMA (1913)

With the ever-increasing evidence of the relationship between milk and the spread of various infections with members of the streptococcus group, methods for their detection in milk and for distinguishing the different types present have been devised. The direct examination of the stained sediment, originally employed as a means of discovering inflammation of the udder, has been used in an attempt to separate pathogenic and harmless streptococci. Thus, Lewis<sup>1</sup>differentiates these organisms according to the length of the chain and irregularities in the size of the individual cocci. Ruediger,<sup>2</sup>however, believes that these are unreliable grounds of distinction, while Heinemann,<sup>3</sup>Miller,<sup>4</sup>Hiss and Zinsser<sup>5</sup>and Jordan<sup>6</sup>all state that it is impossible to differentiate with any certainty nocuous from innocuous types. Surely it may be stated that the bacterioscopic method is unsatisfactory for this purpose. Attempts have also been made to distinguish between varieties
INFARCT-RELATED ARTERY PATENCY AFTER EARLY ABCIXIMAB ADMINISTRATION INFLUENCES 1-YEAR MORTALITY IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION TRANSFERRED FOR PRIMARY PCI (DATA FROM EUROTRANSFER REGISTRY)
Authors: Tomasz Rakowski, Zbigniew Siudak, Artur Dziewierz, Ralf Birkemeyer, Magnus Janzon, Wademar Mielecki, Krzysztof Zmudka, Jacek S. Dubiel, Dariusz Dudek
Journal: Journal of the American College of Cardiology (2011)
The Human Skin as a Source of Mima-Herellea Infections
Authors: David Taplin, Gerbert Rebell, Nardo Zaias
Journal: JAMA (1963)

BACTERIA of the<i>Mima-Herellea</i>group were not recognized as distinct and remained undescribed until 1942, when De Bord<sup>1</sup>suggested the name<i>Mimeae</i>for a new tribe of gram-negative, nonmotile organisms which resembled Neisseria morphologically, but differed in biochemical characteristics. He named the two new organisms<i>Mima polymorpha</i>and<i>Herellea vaginicola.</i> During subsequent years, other authors reported similar organisms but gave them different names so that the situation became extremely confusing. Synonyms for bacteria in this group include "B5W,"<sup>2</sup><i>Bacterium anitratum</i>,<sup>3</sup><i>Moraxella glucidolytica</i>,<sup>4</sup><i>Achromobacter lwoffi</i>,<sup>5</sup>and<i>Acinetobacter anitratum</i>.<sup>6</sup>Reviews of the literature are given by Rosebury in 1962<sup>7</sup>and Daly et al in 1962.<sup>8</sup> Presumably due to the uncertain taxonomic position of these bacteria, they were not included in the seventh edition of<i>Bergey's Manual of Determinative Bacteriology</i>. This, combined with the confusing variety of synonyms, resulted in failure to identify this group
THE PRESENT STATUS OF OPERATIONS FOR CANCEROUS UTERI.
Authors: HOWARD A. KELLY
Journal: JAMA (1900)

We are one and all curious creatures of habit and victims of fancy. For example, if a little epidemic of smallpox claims a dozen victims or so, everybody is horror-sticken and large numbers of people are vaccinated as a precautionary measure. This is because smallpox is associated with a horrible disfiguring eruption. Thousands of victims die year by year of typhoid fever, in many of our large cities—notably in Philadelphia, through a long series of years—at a time in the world's history when it has long been shown that about one in a hundred thousand is what may be considered an average death-rate in well-regulated communities, and the most public interest that can be aroused is an occasional little spasmodic flutter in the newspapers. And this goes on indefinitely when every child knows that pure water will stop the disease, and when the pure water is within reach. The same
The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia–reperfusion injury in mice
Authors: Manchang Liu, Narsa M. Reddy, Elizabeth M. Higbee, Haranatha R. Potteti, Sanjeev Noel, Lorraine Racusen, Thomas W. Kensler, Michael B. Sporn, Sekhar P. Reddy, Hamid Rabb
Journal: Kidney International (2013)
Reproducibility of clinical and hemodynamic parameters during pacing stress testing in patients with angina pectoris.
Authors: U Thadani, J R Lewis, T M Mathew, R O West, J O Parker
Journal: Circulation (1979)

The reproducibility of clinical and hemodynamic events during two successive pacing periods separated by a 20-minute interval was evaluated in 33 patients with stable angina pectoris.Continuous pacing with stepwise increase in pacing rate was assessed in 19 patients and discontinuous pacing in which pacing was temporarily interrupted at each rate was evaluated in the other 14 patients.During continuous pacing, the group values for pacing rates that induced angina, the pacing time to angina, ST-segment depression, rate-pressure product, cardiac output and left ventricular end-diastolic pressure (LVEDP) were similar during the two pacing periods, but postpacing LVEDP was lower after the second pacing period (p < 0.05).During the second pacing period, angina could not be reproduced at the same pacing rates in four patients and postpacing LVEDP varied by 5 mm Hg or more in 10 of the 19 patients.During discontinuous pacing, the group mean values for pacing rates that induced angina and the pacing time to angina were higher (p < 0.05), and cardiac output lower (p < 0.05) during the second pacing period, while rate-pressure product, ST-segment depression, and LVEDP were similar during the two pacing periods.During the second pacing study, angina could not be induced at the same pacing rates in six patients and the postpacing LVEDP varied by 5 mm Hg or more in three of the 14 patients.The results show that continuous pacing is preferable to discontinuous pacing.With continuous pacing, the group values for the clinical and many of the hemodynamic parameters were reproducible.We recommend the demonstration of the reproducibility of events during pacing in studies in which the effects of therapeutic in- terventions are being assessed, especially in a small number of patients.
Comment on: Cohen et al. Effects of Gastric Bypass Surgery in Patients With Type 2 Diabetes and Only Mild Obesity. Diabetes Care 2012;35:1420–1428
Authors: John G. Kral
Journal: Diabetes Care (2013)

Cohen et al. (1) are to be commended for their observational study of 30 patients with longstanding diabetes and BMI 30–35 kg/m2 who were followed for 6 years after laparoscopic Roux-en-Y gastric bypass (LRYGB). The study appropriately challenges using threshold levels to determine indications for treatment based on a continuous variable, BMI (size), which in itself is not a measure of any disease (unlike blood pressure, fasting plasma glucose, or triglycerides).

Several items require clarification:

1.  National Institutes of Health Consensus Development Conferences such as the Gastrointestinal Surgery for Severe Obesity conference in 1991 do not “bound” or “set limits” for treatments: they provide recommendations based on presented evidence. However, third- …
Myocardial potassium uptake and catecholamine release during cardiac sympathetic nerve stimulation
Authors: O. ELLINGSEN, O. A VENGEN, S. E KJELDSEN, I. EIDE, A. ILEBEKK
Journal: Cardiovascular Research (1987)

Journal Article Myocardial potassium uptake and catecholamine release during cardiac sympathetic nerve stimulation Get access ØYVIND ELLINGSEN, ØYVIND ELLINGSEN ** From the Institute for Experimental Research, University of Oslo, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar ØYSTEIN A VENGEN, ØYSTEIN A VENGEN ** From the Institute for Experimental Research, University of Oslo, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar SVERRE E KJELDSEN, SVERRE E KJELDSEN †From the Medical Department, Ullevaal Hospital, Oslo, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar IVAR EIDE, IVAR EIDE †From the Medical Department, Ullevaal Hospital, Oslo, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar ARNFINN ILEBEKK ARNFINN ILEBEKK ** From the Institute for Experimental Research, University of Oslo, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 12, December 1987, Pages 892–901, https://doi.org/10.1093/cvr/21.12.892 Published: 01 December 1987 Article history Received: 18 February 1987 Accepted: 25 June 1987 Published: 01 December 1987