tbuckley/cabot-search huggingface dataset:
Abstract 2431: IGF1R/IR axis is a novel treatment target in ER-negative breast cancer.
Authors: Kazuharu Kai, Kimie Kondo, Naoto Ueno
Journal: Cancer Research (2013)

Abstract Background/Hypothesis: Insulin growth factor-1 receptor (IGF1R) and insulin receptor (IR) are overexpressed in a subpopulation of breast cancers (BCs). However, the clinical significance of IGF1R/IR is not fully understood, especially in ER-negative BC, which is aggressive and lacks molecularly targeted therapies. The objective of this study was to rationally develop treatment strategies for ER-negative BC with IGF1R/IR inhibitor. Method: We treated 6 ER-negative BC cell lines that express IGF1R/IR and have p53 mutations, a genetic hallmark of ER-negative BC, with KW2450, a dual tyrosine-kinase inhibitor against IGFR/IR. Western blot analysis was performed to confirm IGF1R, IR, or phosphor-IGFR/IR expression. To evaluate growth-inhibition effect, Cell-titer-blue assay and xenograft model were performed in vitro and in vivo. For apoptosis assay, Annexin V staining and western blotting of cleaved-caspase 8 and -PARP were performed. The amounts of intracellular reactive oxygen species (ROS) were measured as a candidate marker in predicting the efficacy of KW2450. Result: The values of IC50 are shown in the table. In cell-cycle analysis, all 6 cell lines treated with KW2450 accumulated in the G2/M phase and underwent cell death (sub-G1) in a dose-dependent manner. MCF7 and ZR15.1 cells, which have wild-type p53, had the same response to KW2450, which suggests that this phenotype is independent of p53 function. We attributed this cell death to apoptosis following apoptosis assay using one of the most sensitive cell lines, MDA-MB-468. We found that ROS accumulation correlated with a susceptibility to cell death at the dose of 0.5 μm, as shown below. In the xenograft model, we used SUM149 cells, a widely-used model, and saw a significant tumor growth-inhibitory effect at 20 or 40 mg/kg/day compared with vehicle control. Conclusion: ER-negative BCs that express IGF1R or IR are sensitive to KW2450. ROS accumulation with KW2450 treatment may be a good predictive marker of patient benefit from KW2450 treatment. Molecular/genetic profiles and IC50s to KW-2450 in breast cancer cell lines, TN; triple-negative Cell line SUM149 MDA-MB-231 MDA-MB-468 BT-549 HCC70 SUM190 Subtype TN TN TN TN TN HER2+ p53 genotype M237I R280K R273H R249S R248Q Q317stop IC50 (μM) 0.23 0.35 0.27 0.28 0.26 1.72 % of dead cells 8.1 ± 0.2 7.3 ± 0.5 27.3 ± 0.9 NA NA NA % of ROS+ cells 3.6 ± 0.8 5.9 ± 0.4 62.5 ± 4.6 NA NA NA Citation Format: Kazuharu Kai, Kimie Kondo, Naoto Ueno. IGF1R/IR axis is a novel treatment target in ER-negative breast cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2431. doi:10.1158/1538-7445.AM2013-2431
Update in Pulmonary Diseases
Authors: Martin J. Tobin
Journal: Annals of Internal Medicine (2005)

Updates15 February 2005Update in Pulmonary DiseasesMartin J. Tobin, MDMartin J. Tobin, MDFrom Loyola University Medical Center and Hines Veterans Affairs Hospital, Maywood, Illinois.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-4-200502150-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This year's Update in Pulmonary Diseases incorporates articles on the following topics: mechanical ventilation, obstructive lung disease, and pulmonary infection.Mechanical VentilationPhysician Training Did Not Provide Adequate Education on Mechanical Ventilation Cox CE, Carson SS, Ely EW, et al. Effectiveness of medical resident education in mechanical ventilation. Am J Respir Crit Care Med. 2003;167:32-8. [PMID: 12406827]Only 37% of critically ill patients receive care from an intensive care specialist. National surveys show that 67% of patients admitted to intensive care units remain in the care of their primary physicians and that 59% of general internists in practice use mechanical ventilation.Cox ...Reference1. Mehta S, Jay GD, Woolard RH, Hipona RA, Connolly EM, Cimini DM, et al. Randomized, prospective trial of bilevel versus continuous positive airway pressure in acute pulmonary edema. Crit Care Med. 1997;25:620-8. [PMID: 9142026] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Loyola University Medical Center and Hines Veterans Affairs Hospital, Maywood, Illinois.Grant Support: By a Merit Review grant from the Veterans Affairs Research Service.Disclosures: None disclosed.Corresponding Author: Martin J. Tobin, MD, Division of Pulmonary and Critical Care Medicine, Hines Veterans Affairs Hospital, Route 111N, Hines, IL 60141; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKv7 Channels in Lung DiseasesTidal Volume Reduction in Patients with Acute Lung Injury When Plateau Pressures Are Not High 15 February 2005Volume 142, Issue 4Page: 283-288KeywordsExerciseLungsNoninvasive ventilationPneumoniaPulmonary diseasesSurgeryTidal volumeVentilators ePublished: 15 February 2005 Issue Published: 15 February 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
UK based Iraqi doctor named as health minister
Authors: Owen Dyer
Journal: BMJ (2007)

Iraqi doctors last week gathered in London with representatives of international relief agencies to discuss health policy and humanitarian aid efforts in their wartorn country. The Iraq Health Crisis Conference, organised by the health charity Medact, also heard from Sabah Sadik, a psychiatrist from Kent, whom the Iraqi government has named as the country's next health minister.

Dr Sadik, currently the medical director of Kent and Medway NHS and Social Care Partnership Trust, is expected to leave Britain this summer to start his new job. He is the sole nominee for the post vacated by Ali al-Shemari, one of six …
The Asthma Disease Activity Score: A discriminating, responsive measure predicts future asthma attacks
Authors: Steven Greenberg, Nancy Liu, Amarjot Kaur, Mani Lakshminarayanan, Yijie Zhou, Linda Nelsen, Davis F. Gates, Wen-Ling Kuo, Steven S. Smugar, Theodore F. Reiss, Neil Barnes, Anne Fuhlbrigge, Henry Milgrom, Michael Schatz, Barbara Knorr
Journal: Journal of Allergy and Clinical Immunology (2012)
A comparison of astemizole and chlorpheniramine in dermographic urticaria
Authors: L.B. KRAUSE, SAM SHUSTER
Journal: British Journal of Dermatology (1985)

Journal Article A comparison of astemizole and chlorpheniramine in dermographic urticaria Get access L.B. KRAUSE, L.B. KRAUSE University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K. Search for other works by this author on: Oxford Academic Google Scholar SAM SHUSTER SAM SHUSTER University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 112, Issue 4, 1 April 1985, Pages 447–453, https://doi.org/10.1111/j.1365-2133.1985.tb02319.x Published: 01 April 1985 Article history Accepted: 04 September 1984 Published: 01 April 1985
Fas gene promoter polymorphisms in primary Sjogren's syndrome
Authors: C G Mullighan
Journal: Annals of the Rheumatic Diseases (2003)

Fas mediated apoptosis may be important in the pathogenesis of primary Sjögren's syndrome (pSS).To examine genetic variation in the promoter region of the Fas gene in pSS.Two single nucleotide polymorphisms at positions -1377(G/A) and -670(G/A) in the Fas gene promoter were genotyped by PCR-SSP in 101 patients with pSS and 108 Caucasoid controls.No significant differences in allele or genotype frequencies were detected between the patients with pSS and controls. However, significant associations were observed with Ro/La autoantibody negative patients, who display milder and later onset disease. The -670A allele was more frequent in Ro/La autoantibody negative patients than in Ro/La autoantibody positive patients (p = 0.04).This study does not confirm an earlier report of an association between pSS and the Fas promoter -670G allele. However, the results suggest that genetically determined variability in Fas expression may modulate Ro/La autoantibody responses in patients with pSS.
Dermatomyositis presenting in pregnancy
Authors: A. HARRIS, M. WEBLEY, M. USHERWOOD, S. BURGE
Journal: British Journal of Dermatology (2006)

We report the onset of dermatomyositis in a woman pregnant 38‐weeks who subsequently delivered a healthy infant. The disease improved rapidly following delivery. The association of dermatomyositis with pregnancy is unusual, and fetal outcome may be adversely affected.
MULTI ELECTRODE RENAL SYMPATHETIC DENERVATION IMPROVES HEART RATE DYNAMICS IN PATIENTS WITH DRUG-RESISTANT HYPERTENSION
Authors: Konstantinos P. Tsioufis, Vasilios Papademetriou, Dimitris Tsiachris, Kyriakos Dimitriadis, Alexandros Kasiakogias, Athanasios Kordalis, Velissarios Antonakis, Anna Kefala, Ioannis Kallikazaros, Elizabeth Oi-Yan Lau, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2014)
The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial
Authors: Peter W. Hunt, Nancy S. Shulman, Timothy L. Hayes, Viktor Dahl, Ma Somsouk, Nicholas T. Funderburg, Bridget McLaughlin, Alan L. Landay, Oluwatoyin Adeyemi, Lee E. Gilman, Brian Clagett, Benigno Rodriguez, Jeffrey N. Martin, Timothy W. Schacker, Barbara L. Shacklett, Sarah Palmer, Michael M. Lederman, Steven G. Deeks
Journal: Blood (2013)
Analysis of trends in cancer mortality in England and Wales during 1951-80 separating changes associated with period of birth and period of death.
Authors: C Osmond, M J Gardner, E D Acheson
Journal: BMJ (1982)

Cancer mortality rates in England and Wales were analysed so to describe simultaneously changes affecting successive generations--that is, associated with period of birth--as well as changes associated with the period of which the deaths took place. When mortality from all cancers was considered the analysis implied that, contrary to a widely held view, the rate of death from cancer had been declining in each sex in successive generations. For men the decline had occurred in generations born since 1900, whereas for women the peak came in the 1925 birth group. On the other hand, there had been little decline in the rates associated with period of death. Five examples of cancers of specific organs for which the trends contrasted are shown.
Colonoscopy - Is Sedation Necessary And Is There Any Role For Intravenous Propofol?
Authors: G. D. Bell, J. E. Charlton
Journal: Endoscopy (2000)

Colonoscopy remains a difficult and at times frustratingly lengthy procedure, and it has been suggested that a trainee endoscopist may need to perform over 200 supervised examinations to become reasonably proficient [1]. The passage of a flexible endoscope along a floppy, highly distensible and mobile length of bowel frequently causes painful looping of the instrument [2]. As stated in a recent edition of a standard textbook, “some stretching of peritoneal attachments is inevitable, at least transiently, during colonoscopy. This may cause gnawing or acute unpleasant visceral pain. Coupled with the sensation of rectal fullness simulating the desire to defaecate, this makes a slow examination difficult to bear for some patients …” [3].
Doctors should be able to pursue joint career in medicine and management, report says
Authors: Zosia Kmietowicz
Journal: BMJ (2008)

A new career pathway that lets doctors straddle the worlds of clinical medicine and management in the NHS is needed to allow doctors’ careers to flourish in today’s healthcare system, a new report says.

The role of doctors is changing, states the report from the healthcare think tank the King’s Fund and the Royal College of Physicians, and other health professionals are taking responsibility from doctors for managing some aspects of patients’ care.

Consultations about the meaning of medical professionalism with more than 400 doctors at 10 events in England …
Prolonged Immunological Disorder Terminating in Hematological Malignancy: A Human Analogue of Animal Disease?
Authors: ROSALINE R. JOSEPH
Journal: Annals of Internal Medicine (1970)

A patient developed monoclonal gammopathy, autoimmune phenomenon, and acute leukemia in that sequence over a 7-year period. A comparison is made with Aleutian mink disease as well as with the autoimmune and lymphomatous disorders observed in New Zealand black mice.
Drug eluting stents match bypass surgery for mortality in registry study, but trial shows higher event rate
Authors: S. Mayor
Journal: BMJ (2015)

Percutaneous coronary intervention (PCI) with second generation drug eluting stents is associated with similar mortality as coronary artery bypass grafting (CABG) in patients with multi-vessel coronary artery disease, the results of a real world registry study have shown,1 but a randomised trial found a higher event risk.2

The observational registry study,1 reported in the New England Journal of Medicine , compared 9223 patients who underwent PCI using everolimus eluting stents with 9223 patients who underwent CABG. The two groups were selected from a New York registry of 34 819 …
Definition of Microalbuminuria in First-Morning and Random Spot Urine in Diabetic Patients
Authors: Tetsuya Babazono, Chieko Takahashi, Yasuhiko Iwamoto
Journal: Diabetes Care (2004)

Measurement of albumin excretion in a 24-h urine collection has long been the “gold standard” for quantitative evaluation of albuminuria in diabetic patients; however, collection errors due to improper timing and missed samples may lead to significant over- and underestimation of albuminuria. For convenience and consistency, the American Diabetes Association (1) and the National Kidney Foundation (2) have recently recommended measurement of albumin-to-creatinine ratio (ACR) in a random spot urine collection for diagnosis of microalbuminuria. Microalbuminuria is diagnosed if ACR ranges between 30 and 300 mg/g creatinine. The guidelines recommended using a first-morning sample because of the potentially …
Mania and the Use of Lithium: A Three-Year Study
Authors: EDWARD J. LYNN, AARON SATLOFF, DAVID C. TINLING
Journal: American Journal of Psychiatry (1971)

The authors focus on the problem of differential diagnosis between mania and schizophrenia and also upon the toxic aspects of lithium therapy. An approach to the diagnostic evaluation of the psychotic patient is urged that recognizes several positive criteria for mania and schizophrenia and relates them to the temporal sequence of the diagnostic process. Diagnostic confusion regarding delirium in patients on lithium and the problems of weekend coverage and supervision by personnel unfamiliar with lithium treatment are seen as special problems that must be dealt with to prevent severe toxic reactions.
Medical treatment at the Glastonbury Festival. Costs are predictable.
Authors: C Howes
Journal: BMJ (1993)

<h3>ABSTRACT</h3> <h3>Objective</h3> chronic inflammation and immune dysregulation are crucial mechanisms for atherosclerosis in rheumatoid arthritis (RA). Recent evidence suggests a link via humoral responses against high-density lipoproteins (HDL). However, their specificity, clinical relevance and emergence along disease course are unknown, especially during the earliest phases of RA. <h3>Methods</h3> IgG and IgM serum levels of antibodies against HDL (anti-HDL) and Apolipoprotein A1 (anti-ApoA1) were measured in 82 early RA patients, 14 arthralgia individuals and 96 controls. Established RA patients (n=42) were included for validation. Atherosclerosis and vascular stiffness were measured by Doppler-ultrasound. Lipoprotein content, particle numbers and size were measured by H-NMR. Cytokines were measured by immunoassays. A cardiometabolic-related protein panel was evaluated using high- throughput targeted proteomics. <h3>Results</h3> anti-HDL and anti-ApoA1 responses were increased in early RA compared to controls (both p&lt;0.001) and were comparable to established disease. Only anti-ApoA1 antibodies were increased in arthralgia. IgG anti-HDL and anti-ApoA1 were associated with unfavourable lipoprotein traits in RA and arthralgia, respectively. A similar picture was observed for inflammatory mediators. No associations with clinical features or risk factors were found. IgG anti-HDL were independently associated with atherosclerosis occurrence in early RA, and outperformed patient stratification over conventional algorithms (mSCORE) and their anti-ApoA1 counterparts. Anti-HDL antibodies correlated with proteins involved in immune activation, remodelling, and lipid metabolism pathways in early RA. <h3>Conclusion</h3> humoral responses against HDL particles are an early event along arthritis course, although quantitative and qualitative differences can be noticed among stages. These differences informed distinct capacities as biomarkers and underlying pathogenic circuits.
VORTEX FLOW FORMATION IN PATIENTS AFTER TETRALOGY OF FALLOT REPAIR WITH PULMONARY REGURGITATION UTILIZING 3-DIMENSIONAL PHASE ENCODED VELOCITY MAPPING - A CLUE TO POWER LOSS, POOR EXERCISE PERFORMANCE AND BETTER SURGERY
Authors: Mark A. Fogel, Kartik Sundareswaran, Matthew Harris, Elizabeth Goldmuntz, Ajit Yoganathan
Journal: Journal of the American College of Cardiology (2010)
HIV positive doctors deserve support
Authors: R. Drew, G. Foster
Journal: BMJ (1997)

The display and analysis of functional brain images often benefit from head rotational correction and centering. An automated method was developed to align brain PET images into a standard three-dimensional orientation. The algorithm performs transverse and coronal rotational correction as well as centering of a brain image set. Optimal rotational correction and centering are determined by maximizing a bilateral hemispheric similarity index, the stochastic sign change criterion. Testing of this algorithm on simulated symmetrical brain image sets showed errors less than 1.0 degree and 0.5 pixels for rotational correction and centering, respectively. With actual PET data, the algorithm results correlated well with those obtained by visual inspection. Testing on asymmetrical brain image sets with simulated lesions indicated that performance of the algorithm is not sensitive to focal asymmetries. This automated method provides objective, reproducible image alignment into a standard orientation and facilitates subsequent data analysis techniques for functional brain images.
Services for disabled people are "unacceptably poor"
Authors: Z. Kmietowicz
Journal: BMJ (2000)

The NHS has promised to upgrade equipment and services for disabled people after a critical report by the Audit Commission.

Many of the four million older and disabled people living in England and Wales receive a service that is “unacceptably poor,” according to the report. Patients often wait longer than six months to be fitted with a hearing aid but because of the poor quality of the hearing aids or misunderstood instructions a third are used rarely or never. Many people who need artificial …
Liver transplantation in patients with hepatitis B virus infection: Outcome in asian versus white patients
Authors: Eng-Kiong Teo, Steven-Huy Han, Norah Terrault, Velimir Luketic, Donald Jensen, Emmet B. Keeffe, Anna S.F. Lok
Journal: Hepatology (2001)

Previous studies have found that Asian patients transplanted for hepatitis B virus (HBV) infection had worse outcomes than white patients. The aim of this study was to compare outcomes in Asian and white patients listed for liver transplantation for HBV infection. Data of all patients with HBV infection listed for liver transplantation between January 1996 and June 1998 from 20 centers in North America were collected using a survey. Total patients enrolled were 325 (171 whites, 126 Asians, 28 other races). There was no difference in demographics, liver biochemistry, and HBV replicative status between Asians and whites at the time of listing. More Asians had hepatocellular carcinoma and fewer Asians had hepatitis C or D virus coinfection. At the time of this survey, 70 Asians (55%) and 99 whites (58%) had been transplanted. Actuarial 2–year survival posttransplantation for Asians (88%) and whites (92%) was similar. Recurrent HBV infection occurred in 8 (11%) Asians and 12 (12%) whites. Five patients with recurrent HBV infection died, 4 of whom were Asian. Actuarial 2–year survival for Asians versus whites with recurrent HBV infection was 60% versus 90% ( P = .04). In this large cohort of patients, overall survival and recurrent HBV infection posttransplantation were comparable between Asians and whites. However, Asians with recurrent HBV infection posttransplantation had significantly higher mortality.
Mass Screening for the Detection of β-Thalassemia Trait.
Authors: Peter McPhedran
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Mass Screening for the Detection of β-Thalassemia Trait.Peter McPhedran, M.D., Jack Weinstein, M.D., Marshall G. Barnes, M.D., Gloria Geloso, A.S.Peter McPhedran, M.D.Search for more papers by this author, Jack Weinstein, M.D.Search for more papers by this author, Marshall G. Barnes, M.D.Search for more papers by this author, Gloria Geloso, A.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-823_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe detection of sickle-cell trait for the purpose of genetic counseling is important enough to justify mass screening programs. The detection of β-thalassemia trait is important both for genetic counseling and for the diagnosis of anemia, but detection methods have been too cumbersome for mass screening. We have previously shown that microcytosis identified by the Model S Coulter Counter (Coulter Electronics, Inc., Hialeah, Florida) is a useful clue to the diagnosis of β-thalassemia trait, and we have recently completed a large screening program for microcytosis. Between March 1971 and October 1972, 1000 patients (about 1% of those having blood counts... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Peter McPhedran, M.D.; Jack Weinstein, M.D.; Marshall G. Barnes, M.D.; Gloria Geloso, A.S.Affiliations: New Haven, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Laboratory Evaluation of Microcytic Red Blood CellsThe diagnosis of beta-thalassemia trait: A review 1 May 1973Volume 78, Issue 5 Page: 823-823 Keywords Anemia Blood counts Genetic counseling ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...