tbuckley/cabot-search huggingface dataset:
Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome
Authors: Mathieu Lemaire, Véronique Frémeaux-Bacchi, Franz Schaefer, Murim Choi, Wai Ho Tang, Moglie Le Quintrec, Fadi Fakhouri, Sophie Taque, François Nobili, Frank Martinez, Weizhen Ji, John D Overton, Shrikant M Mane, Gudrun Nürnberg, Janine Altmüller, Holger Thiele, Denis Morin, Georges Deschenes, Véronique Baudouin, Brigitte Llanas, Laure Collard, Mohammed A Majid, Eva Simkova, Peter Nürnberg, Nathalie Rioux-Leclerc, Gilbert W Moeckel, Marie Claire Gubler, John Hwa, Chantal Loirat, Richard P Lifton
Journal: Nature Genetics (2013)
Infectious Diseases in the Pediatric Intensive Care Unit
Authors: Mark D. Widome
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME TOXEMIAS IN RELATION TO THE PRODUCTION OF NERVOUS AND MENTAL DISEASES.
Authors: SAMUEL BELL
Journal: JAMA (1904)

There is to-day no specialty in the field of medicine which presents more difficulties and dissensions among alienists and other scientific investigators than the satisfactory diagnosis, comprehension and treatment of disorders relating to the nervous system. Although more than two centuries have elapsed since Hippocrates prepared a foundation for the science of psychiatry, a rational and universally acceptable conception of diseases presenting symptoms referable to disorder in nerve structure or function, has not been reached. It can not be denied, however, that, when the cause of a certain morbid process is discovered, the treatment of the case can be made more rational and effective. If we as clinicians, would be more thorough and studious in the consideration and investigation of a case, instead of treating it along general text-book rules, the treatment and progress of the disease would resolve itself into a more rational and less difficult problem. I am
SOME REMARKS ON MALIGNANT GROWTHS.
Authors: EDWIN KLEBS
Journal: JAMA (1897)

The expression "malignancy" is now reserved for such pathologic new formations that will often return after removal and form metastases, if not entirely removed. As the first depends upon incomplete removal, mostly depending on dissemination of tumorgerms in the various forms of the primary growth, the latter property only is the true feature of malignant tumors. To clear up the nature of this property is a task of the highest scientific and practical importance, and it seems always convenient to review our notions on these points, even though they are not wholly conclusive. At least, such an examination of facts will show the way for further investigation and secure the practitioner and pathologic investigator from mistakes, by removing misunderstandings. Separating the infectious tumors from the organoid growths, in the second part of my "General Pathology" (1889) I think I have placed the question somewhat clearer. The organoid tumors spread by
IL15RA Drives Antagonistic Mechanisms of Cancer Development and Immune Control in Lymphocyte-Enriched Triple-Negative Breast Cancers
Authors: Pierfrancesco Marra, Sumi Mathew, Anita Grigoriadis, Yin Wu, Fernanda Kyle-Cezar, Johnathan Watkins, Mamunur Rashid, Emanuele De Rinaldis, Sonya Hessey, Patrycja Gazinska, Adrian Hayday, Andrew Tutt
Journal: Cancer Research (2014)

Despite its aggressive nature, triple-negative breast cancer (TNBC) often exhibits leucocyte infiltrations that correlate with favorable prognosis. In this study, we offer an explanation for this apparent conundrum by defining TNBC cell subsets that overexpress the IL15 immune receptor IL15RA. This receptor usually forms a heterotrimer with the IL2 receptors IL2RB and IL2RG, which regulates the proliferation and differentiation of cytotoxic T cells and NK cells. However, unlike IL15RA, the IL2RB and IL2RG receptors are not upregulated in basal-like TNBC breast cancer cells that express IL15RA. Mechanistic investigations indicated that IL15RA signaling activated JAK1, STAT1, STAT2, AKT, PRAS40, and ERK1/2 in the absence of IL2RB and IL2RG, whereas neither STAT5 nor JAK2 were activated. RNAi-mediated attenuation of IL15RA established its role in cell growth, apoptosis, and migration, whereas expression of the IL15 cytokine in IL15RA-expressing cells stimulated an autocrine signaling cascade that promoted cell proliferation and migration and blocked apoptosis. Notably, coexpression of IL15RA and IL15 was also sufficient to activate peripheral blood mononuclear cells upon coculture in a paracrine signaling manner. Overall, our findings offer a mechanistic explanation for the paradoxical association of some high-grade breast tumors with better survival outcomes, due to engagement of the immune stroma.
Assessment of maternal toxicity, embryotoxicity and teratogenic potential of sodium chlorite in Sprague-Dawley rats.
Authors: D Couri, C H Miller, R J Bull, J M Delphia, E M Ammar
Journal: Environmental Health Perspectives (1982)

Groups of up to 13 pregnant rats were individually caged. Body weight, food and water consumption were recorded at days 1, 8, 15 and 22 of gestation and the dams were treated on days 8-15 with sodium chlorite, 0.1%, 0.5% or 2% in drinking water or by injection of 10, 20, or 50 mg/kg IP or by gavaging with 200 mg/kg. To prevent ingestion of stillborn pups some dams were sacrificed at day 22. Other dams were allowed to deliver at term. Fetuses were weighed, measured and examined for soft tissue and skeletal malformations. Sodium chlorite, 20 or 50 mg/kg daily IP or gavaging with 200 mg/kg, caused vaginal and urethral bleeding. Doses of 10, 20 or 50 mg/kg daily IP caused 0, 50 and 100% mortality of dams, respectively. No deaths were caused by sodium chlorite in the drinking water, but the dams' body weight, water and food consumption decreased during all treatments except 0.1% in the drinking water. Blood smears from the dams injected IP or drinking 2% sodium chlorite showed irregular, bizarre and ruptured erythrocytes. Injection of 10 or 20 mg/kg or drinking 2% resulted in decreased litter size and increased stillbirths and resorption sites. Drinking 0.1% or 0.5% sodium chlorite did not produce any significant embryotoxicity. With all treatments, no significant gross soft tissue or skeletal malformations were observed. Postnatal growth of the pups was not affected by any treatment of the dams during the gestation period.
Light‐heavy chain deposition disease progressing to multiple myeloma
Authors: Danai Daliani, Donna Weber, Raymond Alexanian
Journal: American Journal of Hematology (1995)

Abstract Light chain deposition disease (LCDD) and light and heavy chain deposition disease (LHCDD) are rare clinical entities that have been associated with multiple myeloma, with monoclonal gammopathy of unknown significance (MGUS), or without any detectable protein abnormality. Renal failure is common, the diagnosis is difficult and prolonged survival is rare. The first patient with LHCDD and MGUS who progressed to multiple myeloma after 11 years is presented. A rising level of monoclonal IgA immunoglobulin, bone marrow plasmacytosis, and the presence of multiple bone marrow lesions on magnetic resonance imaging provided the first evidence of disease evolution. When management of serious complications permits a long survival, some patients with LCDD or LHCDD will develop multiple myeloma.
The physicochemical basis of cholesterol gallstone formation in man
Authors: William H. Admirand, Donald M. Small
Journal: Journal of Clinical Investigation (1968)

The concentrations of bile salt, lecithin, and cholesterol were determined on each of 66 samples of gall bladder bile from patients with cholesterol gallstones and 25 samples of normal gall bladder bile. When these three constituents were plotted simultaneously on triangular coordinates, a complete separation of the normal and "abnormal" bile was achieved. This separation was the result of an increase in the quantity of cholesterol relative to the amounts of bile salts and lecithin contained in the bile from patients with cholesterol gallstones. An in vitro model system was constructed (on triangular coordinates) that allows prediction of the maximum amount of cholesterol that can be solubilized in solutions containing varying proportions of bile salt and lecithin. When the bile data were compared with the solubility of cholesterol derived from the model system, normal biles were found to be less than saturated with cholesterol, whereas biles from patients with cholesterol gallstones were saturated and in some cases contained insoluble cholesterol in the form of microcrystals. It is suggested that the physical state of bile (i.e., the presence or absence of insoluble cholesterol) is determined by the relative concentrations of bile salt, lecithin, and cholesterol, and the other biliary constituents do not appear to significantly effect the solubility of cholesterol in bile.
Common Prescribing Errors
Authors: Timothy S. Lesar
Journal: Annals of Internal Medicine (1992)

Letters15 September 1992Common Prescribing ErrorsTimothy S. Lesar, PharmDTimothy S. Lesar, PharmDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-6-537_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: From 1 April 1991 to 31 March 1992, we detected 118 instances of the prescribing of an inappropriate dosage form of a drug available as both a "standard" and a "controlled" release product. This number compares with only 19 such errors in 1987 (1). All errors were averted before drug dispensing from the pharmacy.The drugs involved were diltiazem (32 errors), nifedipine (27), verapamil (23), theophylline (14), propranolol (5), morphine (4), procainamide (4), isosorbide (3), albuterol (3), divalproex (2), and disopyramide (1). The most common type of error was prescribing the standard-release dosage form (or not specifying...References1. LesarBricelandDelcoureCrilly-ParmaleeMasta-GornickPohl TLKJVH. Medication prescribing errors in a teaching hospital. JAMA. 1990;263:2329-34. CrossrefMedlineGoogle Scholar2. VitilloLesar JT. Preventing medication prescribing errors. DICP Ann Pharmacother. 1991;25:1388-94. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Albany Medical Center Hospital Albany, NY 12208 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevention of prescription errors by computerized, on-line surveillance of drug order entryMedication errors: considerations for nurse prescribersThe role of perception in Medication Errors : Implications for Non-Technological InterventionsPrescribing errors involving medication dosage formsnoncompliance-with-prescription-writing-requirements-and-prescribing-errors-in-an-outpatient-departmentCauses of prescribing errors in hospital inpatients: a prospective study 15 September 1992Volume 117, Issue 6Page: 537-538KeywordsDrugsMorphine Issue Published: 15 September 1992 PDF downloadLoading ...
LUNG IMPEDANCE MONITORING IN THE OUTPATIENT CLINIC PREDICT HOSPITALIZATIONS OF PATIENTS WITH DECOMPENSATED HEART FAILURE AND ENABLES EARLY THERAPY TO PREVENT HOSPITALIZATIONS
Authors: Michael Shochat, Avraham Shotan, Mark Kazatsker, Vladimir Gurovich, Ilia Shochat, Elena Naiman, Iris Dahan, Aya Asif, David Blondheim, Yaniv Levy, Simcha Meisel
Journal: Journal of the American College of Cardiology (2011)
Randomised controlled trial of the READER method of critical appraisal in general practice
Authors: D. MacAuley, E. McCrum, C. Brown
Journal: BMJ (1998)

<h3>Abstract</h3> <b>Objective:</b> To evaluate the READER model for critical reading by comparing it with a free appraisal, and to explore what factors influence different components of the model. <b>Design:</b> A randomised controlled trial in which two groups of general practitioners assessed three papers from the general practice section of the <i>BMJ</i>. <b>Setting:</b> Northern Ireland. <b>Subjects:</b> 243 general practitioners. <b>Main outcome measures:</b> Scores given using the READER model (Relevance, Education, Applicability, Discrimination, overall Evaluation) and scores given using a free appraisal for scientific quality and an overall total. <b>Results:</b> The hierarchical order for the three papers was different for the two groups, according to the total scores. Participants using the READER method (intervention group) gave a significantly lower total score (P⩽0.01) and a lower score for the scientific quality (P⩽0.0001) for all three papers. Overall more than one in five (22%), and more men than women, read more than 5 articles a month (P⩽0.05). Those who were trainers tended to read more articles (P⩽0.05), and no trainers admitted to reading none. Overall, 58% (135/234) (68% (76/112) of the intervention group) believed that taking part in the exercise would encourage them to be more critical of published articles in the future (P⩽0.01). <b>Conclusion:</b> Participants using the READER model gave a consistently lower overall score and applied a more appropriate appraisal to the methodology of the studies. The method was both accurate and repeatable. No intrinsic factors influenced the scores, so the model is appropriate for use by all general practitioners regardless of their seniority, location, teaching or training experience, and the number of articles they read regularly.
Assisted reproduction increases risk of birth defects, study says
Authors: S. Gottlieb
Journal: BMJ (2002)

Babies born through assisted reproduction may have a nearly 1 in 10 risk of major birth defects—twice the risk among babies born naturally.

Fertility experts were quick to caution that these findings contradict smaller studies that failed to find any increased risk of birth defects from the procedures. They said new studies would be needed to confirm the 1 in 10 risk.

In a study published in the New England Journal of Medicine (2002;346:725-30) Dr Jennifer Kurinczuk, at the time a researcher at the Institute for Child Health Research at the University of Western Australia in Perth, and colleagues looked at the rate of major defects in babies …
Acute effects of surgery on emotion and personality of brain tumor patients: surgery impact, histological aspects, and recovery
Authors: Fabio Campanella, Franco Fabbro, Tamara Ius, Tim Shallice, Miran Skrap
Journal: Neuro-Oncology (2015)

Cognitive effects of brain surgery for the removal of intracranial tumors are still under investigation. For many basic sensory/motor or language-based functions, focal, albeit transient, cognitive deficits have been reported low-grade gliomas (LGGs); however, the effects of surgery on higher-level cognitive functions are still largely unknown. It has recently been shown that, following brain tumors, damage to different brain regions causes a variety of deficits at different levels in the perception and interpretation of emotions and intentions. However, the effects of different tumor histologies and, more importantly, the effects of surgery on these functions have not been examined. The performance of 66 patients affected by high-grade glioma (HGG), LGG, and meningioma on 4 tasks tapping different levels of perception and interpretations of emotion and intentions was assessed before, immediately after, and (for LGG patients) 4 months following surgery. Results showed that HGG patients were generally already impaired in the more perceptual tasks before surgery and did not show surgery effects. Conversely, LGG patients, who were unimpaired before surgery, showed a significant deficit in perceptual tasks immediately after surgery that was recovered within few months. Meningioma patients were substantially unimpaired in all tasks. These results show that surgery can be relatively safe for LGG patients with regard to the higher-level, more complex cognitive functions and can provide further useful information to the neurosurgeon and improve communication with both the patient and the relatives about possible changes that can occur immediately after surgery.
Effect of hyperoxia on bronchial response to inhaled methacholine
Authors: A. Wollner, L. Ben‐Dov, E. Bar‐Yishay
Journal: Allergy (1991)

Bronchial reactivity to methacholine (MCH) under normoxic and hyperoxic conditions was studied in a double-blind controlled study in 10 normal subjects and nine asthmatic patients. The normal volunteers were challenged while breathing dry, 21% and 100% O2, and the maximal percent falls in forced expired volume in is (FEV1) following inhalation of the highest concentration of MCH (64 mg/ml) were 8 +/- 5% and 9 +/- 8%, respectively; P = NS. The asthmatic patients had their MCH challenge breathing the same gas composition and the provocative concentrations that caused a 20% fall in FEV1 (PC20) were 0.18 mg/ml (range 0.06-5.73) and 0.25 mg/ml (range 0.07-8.49), respectively, which were statistically not significantly different. We conclude that in humans, 100% O2 does not affect bronchial reactivity to MCH.
Areas of Responsibility in Maternal and Child Care
Authors: John R. Evrard
Journal: JAMA (1966)

<h3>To the Editor:—</h3> The Division on Maternal and Child Welfare of the State Medical Society of Wisconsin in cooperation with the Division of Maternal and Child Health of the Wisconsin State Board of Health has since 1952 conducted a survey of all deaths associated with pregnancy and the postpartum period. Death certificates are coded so that the names of patients, attending physicians, and hospitals are known only to the persons coding and to the interviewer. Where death is due to obstetric causes, data are secured by personal interview with the attending physician and a review of his office and hospital records. The interviews are done by board-certified obstetricians. The Maternal Mortality Study Committee consists of obstetricians, a pathologist, an anesthesiologist, a generalist, and the director of the Division of Maternal and Child Health of the state board of health. In the last five years the hospital maternal and child health
A Systematic Review and Meta-Analysis of Utility-Based Quality of Life in Chronic Kidney Disease Treatments
Authors: Melanie Wyld, Rachael Lisa Morton, Andrew Hayen, Kirsten Howard, Angela Claire Webster
Journal: PLoS Medicine (2012)

Melanie Wyld and colleagues examined previously published studies to assess pooled utility-based quality of life of the various treatments for chronic kidney disease. They conclude that the highest utility was for kidney transplants, with home-based automated peritoneal dialysis being second.
VACCINATION.The Address of Section on State Medicine, Illinois State Medical Society, 1894.
Authors: WM. E. QUINE
Journal: JAMA (1894)

Vaccination was introduced to the attention of the medical profession by Edward Jenner in 1798, as the result of twenty years of investigation. During the century preceding, according to the estimates of our most authoritative statisticians, smallpox, "the most terrible of all the ministers of death," destroyed in Europe alone 50,000,000 human lives. Think of it. Five hundred thousand deaths every year from the most loathsome pestilence known to man; thirteen hundred deaths every day; nearly a death every minute for a hundred years! If it be true, as is believed by enlightened people the world over, that universal vaccination and revaccination, efficiently done, can put an end to the desolation and horror of epidemics of smallpox and possibly eradicate the disease altogether, it would appear that the discoverer of vaccination is the greatest benefactor that mankind has known. Alexander was great. CÆsar was great. Hannibal was great. Napoleon was
Studying the Effectiveness of Palliative Care
Authors: Eduardo Bruera
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Government confirms plan for long term care commission, but details remain sketchy
Authors: L. Eaton
Journal: BMJ (2010)

England’s health secretary, Andrew Lansley, has confirmed that the coalition government plans to hold a commission on the funding of care and support for elderly and disabled people. The commission, first announced in the coalition’s programme for government in May, will be asked to report in a year.

It will include the thorny issue of whether people should be forced to sell their homes to pay for their care. But the exact details of the commission’s remit and membership have yet to be finalised, to the concern of campaigners.

A spokeswoman for Age UK said that the charity was concerned that it doesn’t yet know who will be on the commission. “We haven’t had any news about what exactly the commission is going to be looking at,” she said, and she …
Femoral osteochondral fracture--a non-contact injury in martial arts? A case report.
Authors: C E Mbubaegbu, A J Percy
Journal: British Journal of Sports Medicine (1994)

A report of a case of osteochondral fracture of the lateral femoral condyle in a patient doing a karate kick. The problems related to fixation of osteochondral fragments with protruding screws are highlighted and the suitability of Herbert screw fixation noted.