Insulin Combination Therapy in Type 2 Diabetes Mellitus
Authors: Yusuf Hassan
Journal: Annals of Internal Medicine (2004)

Letters20 April 2004Insulin Combination Therapy in Type 2 Diabetes MellitusYusuf Hassan, MD, Gaurav Gupta, and Saira Hassan, MDYusuf Hassan, MDFrom University of Texas Southwestern Medical School, Garland, TX 75040, and Dallas Veterans Affairs Medical Center, Dallas, TX 75216.Search for more papers by this author, Gaurav GuptaFrom University of Texas Southwestern Medical School, Garland, TX 75040, and Dallas Veterans Affairs Medical Center, Dallas, TX 75216.Search for more papers by this author, and Saira Hassan, MDFrom University of Texas Southwestern Medical School, Garland, TX 75040, and Dallas Veterans Affairs Medical Center, Dallas, TX 75216.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-8-200404200-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Fritsche and colleagues (1) concluded that risk for nocturnal hypoglycemia was lower when glimepiride was combined with morning or bedtime insulin glargine than when it was combined with neutral protamine Hagedorn (NPH) insulin. They also stated that morning insulin glargine provided better glycemic control than bedtime insulin glargine or bedtime NPH insulin.It is important to understand some of the limitations of this study, the most important being the lack of blinding. Hypoglycemia was defined as a blood glucose level less than 4.2 mmol/L (<75 mg/dL), symptomatic or asymptomatic. In addition, while there was no difference in ...References1. Fritsche A, Schweitzer MA, Häring HU. Glimepiride combined with morning insulin glargine, bedtime neutral protamine hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes. A randomized, controlled trial. Ann Intern Med. 2003;138:952-9. [PMID: 12809451] LinkGoogle Scholar2. Sackett DL, Haynes RB, Guyatt GH, Tugwell P. A Basic Science for Clinical Medicine. 2nd ed. Boston: Little, Brown; :201-20. Google Scholar Author, Article, and Disclosure InformationAuthors: Yusuf Hassan, MD; Gaurav Gupta; Saira Hassan, MDAffiliations: From University of Texas Southwestern Medical School, Garland, TX 75040, and Dallas Veterans Affairs Medical Center, Dallas, TX 75216. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGlimepiride Combined with Morning Insulin Glargine, Bedtime Neutral Protamine Hagedorn Insulin, or Bedtime Insulin Glargine in Patients with Type 2 Diabetes Andreas Fritsche , Matthias Axel Schweitzer , and Hans-Ulrich Hring , and the 4001 Study Group*Insulin Combination Therapy in Type 2 Diabetes Mellitus Nasser Mikhail and Soma Wali Insulin Combination Therapy in Type 2 Diabetes Mellitus Andreas Fritsche , Hans-Ulrich Häring , and Matthias Axel Schweitzer Metrics 20 April 2004Volume 140, Issue 8Page: 666KeywordsAbsolute risk reductionBloodGlucoseHemoglobinHypoglycemiaInsulinProtaminesRelative riskType 2 diabetes ePublished: 20 April 2004 Issue Published: 20 April 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...