Human Gamma Globulin
Authors: HUGH FUDENBERG
Journal: Annals of Internal Medicine (1963)

Review1 January 1963Human Gamma GlobulinGenetic Control and Its Relation to DiseaseHUGH FUDENBERG, M.D., E. C. FRANKLIN, M.D.HUGH FUDENBERG, M.D.Search for more papers by this author, E. C. FRANKLIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-171 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe existence of genetically determined differences in certain serum proteins, comparable to genetic variations in blood type, eye color, and other hereditary traits, has become apparent in recent years. Evidence of such intraspecies heterogeneity was provided by the observations of Cumley and Irwin in 1942 (1) and confirmed by Thompson, Foster, Gowen, and Tauber in 1954 (2). In the past 5 years, hereditary differences in several groups of proteins in normal human serum have been definitely delineated. Different types of haptoglobin and of transferrin, for example, can be readily detected by dissimilarities in their electrophoretic behavior in starch gel (3-5)....References1. CUMLEYIRWIN RWMR: Immunogenetic studies of species: segregation of serum components in back-cross individuals. Genetics 27: 177, 1942. CrossrefMedlineGoogle Scholar2. THOMPSONFOSTERGOWENTAUBER SJFJWOE: Hereditary differences in serum proteins of normal mice. Proc. Soc. Exp. Biol. Med. 87: 315, 1954. CrossrefMedlineGoogle Scholar3. SMITHIES O: Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem. J. 61: 629, 1955. CrossrefMedlineGoogle Scholar4. SMITHIESWALKER ONF: Notation for serum-protein groups and the genes controlling their inheritance. Nature (Lond.) 178: 694, 1956. CrossrefMedlineGoogle Scholar5. SMITHIES O: Variations in human serum β-globulins. Nature (Lond.) 180: 1482, 1957. CrossrefMedlineGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: San Francisco, CaliforniaFrom the Departments of Medicine of the University of California School of Medicine, San Francisco, California, and the New York University School of Medicine, New York, New York.Supported by grants H-5997, A-2594, A-1431, and A-5141, United States Public Health Service, and by funds from the Northern California Chapter of the Arthritis and Rheumatism Foundation, and the Committee on Research, University of California School of Medicine, San Francisco.Presented as a basic science lecture at the Forty-third Annual Meeting of The American College of Physicians, Philadelphia, Pennsylvania, April 9-13, 1962.Requests for reprints should be addressed to Hugh Fudenberg, M.D., Department of Medicine, University of California Medical Center, San Francisco, California. 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