tbuckley/cabot-search huggingface dataset:
THE ACTION OF NITRATE OF SILVER UPON THE MUCOUS MEMBRANE OF THE THROAT AND NOSE.
Authors: CARL SEILER
Journal: JAMA (1883)

[Read to the Section on Ophthalmology, Otology, and Laryngology.] It is not my intention to present an exhaustive essay to the Section, but simply to make a few remarks concerning the action of the silver salt upon the mucous membrane, and to record some observations made by myself, with the hope of giving rise to a discussion on this interesting subject. We are all familiar with the popular notion that nitrate of silver is a caustic, and is held in abhorrence by the patients, and used sparingly and in weak solutions by the physician in dealing with inflammations of the mucous membrane of the throat and nose. It may, therefore, be startling to you when I make the statement, the conclusion arrived at from clinical experience and microscopical examination of the tissue, that nitrate of silver, solid or in solution, is not a caustic—<i>i. e.</i>, it does not destroy the
Isolated Right Ventricular Hypoplasia with Atrial Septal Defect or Patent Foramen Ovale
Authors: MARVIN A. SACKNER, MORTON J. ROBINSON, WILLIAM L. JAMISON, DAVID H. LEWIS
Journal: Circulation (1961)

With the rare exception of connective-tissue replacement of the right ventricular myocardium ("parchment heart"), underdevelopment of the right ventricle, as a clinical entity, has been related to tricuspid atresia or stenosis, pulmonary atresia and certain cases of transposition of the great vessels. This report is concerned with four cases, aged 2 months to 39 years, in which a diminutive right ventricle was not dependent on these factors. Three cases occurred in the same family and, in association with atrial septal defect, produced distinctive clinical and hemodynamic features. Right-sided heart failure predominated, dyspnea was mild to moderate, and cyanosis was present in association with clinical, electrocardiographic, and roentgenographic evidence of left ventricular enlargement. Cardiac catheterization and venous angiocardiography showed a bidirectional interatrial shunt, normal pulmonary arterial pressure, no pressure gradient across the pulmonic and tricuspid valves, and a diminutive right ventricle. Anastomosis of the superior vena cava to the right pulmonary artery and closure of the atrial septal defect may ameliorate the hemodynamic disturbance.
A Diet by Any Other Name Is Still About Energy
Authors: Linda Van Horn
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polymer Fume Fever in a Printing Works
Authors: J. A. Barlas
Journal: BMJ (1967)

MEDICBOU 567unconventional advice or resort to selftreatment, at least in the first instance.It is my practice to ask all patients who attend my clinics without the knowledge of their general practitioner if I may write to their doctor informing him of the diagnosis and the treatment I have prescribed, but the vast majority refuse to give me permission to do this ; they are embarrassed, apologetic, but adamant.The usual answer is, " I should be too ashamed," or " I know my doctor far too well to tell him anything about this."Young unmarried patients are rarely ashamed of their sexual activities, but this does not often apply to the older and usually married patient.It is difficult to see, therefore, how one is treating a group of patients " almost as criminals " (to quote Dr.
Systemic interleukin 1 administration suppresses arachidonic acid-induced ear oedema in the mouse
Authors: O. BÄCK, R.C. NEWTON, J.J. HUANG, T.J. LINNA
Journal: British Journal of Dermatology (1989)

Recombinant human interleukin 1 beta (IL-1β), given intraperitoneally to mice as a single injection, significantly suppressed the development of arachidonic acid (AA)-induced ear oedema. This effect was noted 2 h after administration and for at least 5 days afterwards. IL-Iβ was effective in the dose range of 250 ng-20 μg/mouse. Injection of IL-1βper se resulted in erythema of the ears, and thus, IL-1β has the capacity not only to induce and augment but also to suppress inflammatory responses. Indomethacin administered as subcutaneously-implanted pellets did not influence the IL-1β induced-ear erythema, but suppressed to some extent the eflect of IL-1β on the AA-induced ear oedema.
Acute oedema blisters: a report of 13 cases
Authors: M. Bhushan, R.J.G. Chalmers, N.H. Cox
Journal: British Journal of Dermatology (2001)

The development of bullae accompanying acute oedema is a commonly observed clinical sign but has been rarely reported in the literature.To document the clinical features and increase awareness of this entity.Retrospective case note review of 13 inpatient consultation cases seen in two dermatology departments.Oedema blisters appear to be related to the speed of development rather than the degree of oedema, and respond rapidly to the reduction of the underlying oedema.Recognition of oedema blisters is important as they respond quickly and completely to treatment of the underlying oedema.
Hormone Use and Abuse by Athletes
Authors: Dilip R. Patel
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CELL INTERACTIONS IN THE PRIMARY IMMUNE RESPONSE IN VITRO: A REQUIREMENT FOR SPECIFIC CELL CLUSTERS
Authors: Donald E. Mosier
Journal: The Journal of Experimental Medicine (1969)

Mouse spleen cells were found to associate in cell clusters during the primary immune response to sheep erythrocytes in vitro. About 10% of the cell clusters had the following unique properties; (a) they contained most, if not all, antibody-forming cells, (b) they contained only cells forming antibody to one antigen when cell cultures were immunized with two antigens, (c) the cells in clusters reaggregated specifically after dispersion, and (d) the specific reaggregation of clusters appeared to be blocked by antibody to the antigen. The integrity of cell clusters was required for the proliferation of antibody-forming cells, and prevention of clustering by mechanical means or by excess antibody blocked the immune response. Antibody and antigenic determinants on the surfaces of cells probably provide the basis for interaction. The unique microenvironment of cell clusters was essential for the primary immune response in vitro.
Imaging of Diseases of the Chest Edited by Peter Armstrong, Alan G. Wilson, Paul Dee, and David M. Hansell, St. Louis, Mosby-Year Book, Inc., 1994, 971 pages
Authors: Gerard W. Moskowitz
Journal: Clinical Nuclear Medicine (1995)

Director, Division of Nuclear Medicine University of Medicine and Dentistry of New Jersey New Jersey Medical School 150 Bergen Street UH-H-141 Neward, NJ 07103
Chronic infarct‐related artery occlusion is associated with a reduction in capillary density. Effects on infarct healing
Authors: Marek Prech, Stefan Grajek, Andrzej Marszalek, Maciej Lesiak, Marek Jemielity, Aleksander Araszkiewicz, Tatiana Mularek‐Kubzdela, Andrzej Cieslinski
Journal: European Journal of Heart Failure (2005)
COMPARISONS OF 3D- AND 2D-MEASUREMENT TECHNIQUES AND OBSERVATIONAL REAL-TIME ASSESSMENT OF FRONTAL PLANE KNEE CONTROL IN A VERTICAL DROP JUMP LANDING
Authors: K Steffen, T Kroken, T Krosshaug
Journal: British Journal of Sports Medicine (2014)

Background Poor frontal plane knee control is suggested to be a risk factor for anterior cruciate ligament injuries. Both 3D motion analysis and less complex methods, such as 2D video analysis and subjective assessments, have been used to assess frontal plane knee motion. However, the agreement between all three methods has not been investigated. Objective To determine the agreement between 3D and 2D motion analysis and real-time observational assessment of frontal plane knee control in a vertical drop jump (VDJ) landing. Design Observational study. Setting Research laboratory. Participants 119 Norwegian female elite handball players. Risk factor assessment Players performed a VDJ during which movement was recorded with a 3D motion analysis system, a digital video camera, and real-time observational screening in frontal plane. Main outcome measurements 3D and 2D knee-to-ankle separation ratios were calculated to assess frontal plane knee control. A physiotherapist independently scored the knee control as “good”, “reduced” or “poor”. All variables were assessed at peak knee flexion. Results Correlations between 3D and 2D knee-to-ankle-separation ratios and 2D and 3D versus real-time observation ranged from 0.63 to 0.75. Mean 3D and 2D knee-to-ankle-separation ratios were significantly lower for players being scored with “poor” compared to those with “reduced” or “good” frontal knee control. Conclusion Compared with the “gold standard” (3D analysis), both 2D motion analysis and real-time observations seem to be feasible tests to assess frontal knee control. The injury predictive value of the VDJ screening test remains to be answered.
Effect of Hypertension and Cardiac Hypertrophy on Coronary Artery Morphology in Sudden Cardiac Death
Authors: Allen P. Burke, Andrew Farb, You-hui Liang, John Smialek, Renu Virmani
Journal: Circulation (1996)

Epidemiological studies have shown that hypertension and left ventricular hypertrophy (LVH) increase the risk of sudden cardiac death (SCD) in patients with severe coronary artery disease (CAD). However, autopsy studies comparing the morphological substrates for SCD in normotensives and hypertensives are lacking.Heart weight and coronary plaque morphology were prospectively compared in SCD in 36 hypertensive and 63 normotensive individuals. The frequency of CAD was similar in hypertensives (69%, n = 25) and normotensives (73%, n = 46). In 71 hearts with CAD, acute coronary thrombi were present in 76% of normotensives versus 36% of hypertensives (P = .002), LVH was present in 64% of hypertensives versus 33% of normotensives (P = .01) and in 72% of hypertensives with one-vessel disease versus 17% of normotensives with one-vessel disease (P = .0005), and a healed or acute infarct without acute thrombus was present in 36% of hypertensives versus 9% of normotensives (P = .007). Heart weight was higher in all cases of plaque rupture (519 +/- 109 g) than eroded plaque (381 +/- 92 g, P = .0002). In contrast to hypertensives, normotensive hearts with severe CAD showed a stepwise increase in heart weight with one-, two-, and three-vessel disease (P = .01).Severe CAD is present in most SCD in hypertensive and normotensive individuals, but acute thrombi are more common in normotensives. LVH is an important contributing mechanism of SCD in hypertensives, especially in cases of one-vessel disease. LVH is associated with plaque rupture and extent of disease in SCD in normotensives with severe CAD.
The Value of Noninvasive Measurements in Hypertension
Authors: Richard B. Devereux
Journal: JAMA (1990)

High blood pressure is a strong risk factor for cardiovascular disease, but the incidence of morbid events is low for most individuals with hypertension and is not evenly distributed among them. Consequently, treatment guided solely by blood pressure levels may not be sufficiently intensive for high-risk patients, while patients at low risk may be exposed to drug side effects without deriving benefit. This situation may have contributed to the disappointing results of studies of antihypertensive drugs. Although high-risk patients can be identified by traditional measures such as electrocardiographic left ventricular (LV) hypertrophy, fewer than 1% of adults had this abnormality in a recent report from Framingham.<sup>1</sup> This situation has been altered by the development of accurate noninvasive methods of measuring LV muscle mass<sup>2</sup>and carotid atherosclerosis.<sup>3</sup>Studies of patients with hypertension from Cornell<sup>4,5</sup>and middle-aged and older members of the general population in Framingham<sup>1,6</sup>have
Impact of Nutritional Support on Functional Status During an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Authors: HELGA SAUDNY-UNTERBERGER, JAMES G. MARTIN, KATHERINE GRAY-DONALD
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

The impact of oral nutritional supplementation during an acute exacerbation of COPD on functional status was assessed through measuring change in lung function, strength testing, and general well-being. Subjects hospitalized for an acute exacerbation of COPD (n = 33) were randomized to extra nutritional support or the regular hospital care. They consumed an additional 10 kcal/kg/d. Outcome measures were measured at 2 wk as change scores. Forced vital capacity (% predicted) improved in the treatment group as compared with the control group ( + 8.7% versus − 3.5%, p = 0.015), and change in FEV1 was in the same direction but not significantly different (p = 0.099). There were no changes in handgrip strength or respiratory muscle strength, but there was a trend towards more improvement in the general well-being score ( + 11.96 versus − 10.25, p = 0.066). Almost all subjects were in negative nitrogen balance, indicating muscle wasting. The degree of muscle wasting was strongly correlated with the dose of corticosteroids (r = 0.73, p < 0.005). In conclusion, it is difficult to prevent important muscle wasting in patients with COPD treated with corticosteroids, but some small gains were observed with increased dietary intake. Saudny-Unterberger H, Martin JG, Gray-Donald K. Impact of nutritional support on functional status during an acute exacerbation of chronic obstructive pulmonary disease.
Hypothyroidism after treatment with sodium iodide I-131. Incidence and relationship to antithyroid antibodies, long-acting thyroid stimulator (LATS), and infiltrative ophthalmopathy
Authors: G. Burke
Journal: JAMA (1969)

Treatment of hyperthyroidism with sodium iodide I 131 has been implicated as a stimulus to long-acting thyroid stimulator (LATS) production and ophthalmopathy. To evaluate this postulate, we reviewed data of 484 thyrotoxic patients treated with this drug. The incidences of hypothyroidism at one, five, and eight years were 31%, 44%, and 54%, respectively. Of 94 patients with ophthalmopathy, only 19 showed exacerbation unrelated to posttherapy thyroid function after treatment with sodium iodide I 131. In the serum of 25 of 60 patients, LATS was detected, but no evidence of131I-induced LATS formation was seen six weeks to 30 months after treatment. However, elevated antithyroid-antibody titers were noted within six months of treatment, particularly in patients in whom hypothyroidism was developing. There was no correlation between LATS and ophthalmopathy or between LATS and antithyroid antibodies. These data indicate that LATS formation does not result from thyroid injury, but suggest that hypothyroidism which develops after treatment with sodium iodide I 131 is a manifestation of thyroid autoimmune disease.
A conserved idiotype and antibodies to retroviral proteins in systemic lupus erythematosus.
Authors: N Talal, R F Garry, P H Schur, S Alexander, M J Dauphinée, I H Livas, A Ballester, M Takei, H Dang
Journal: Journal of Clinical Investigation (1990)

22 of 61 systemic lupus erythematosus (SLE) patients produced antibodies to the p24 gag protein of HIV-1 demonstrated by Western blotting. 20 of these 22 patients (91%) also express the 4B4 idiotype (Id 4B4) previously identified on a human anti-Sm monoclonal antibody called 4B4. This represents an enrichment for this Id (seen in only 52% of SLE patients generally). Eight of these 22 SLE patients also have anti-Sm antibody activity. Sm partially inhibits the antibody binding of p24 gag suggesting immunologic cross-reactivity between the retroviral antigen p24 gag and the autoantigen Sm. Anti-Id 4B4 also inhibits p24 gag antibody binding by as much as 40%. Finally the monoclonal antibody 4B4 showed cross-reactivity to Sm and p24 gag. The following points emerge from our studies: (a) SLE patients make antibodies to p24 gag of HIV-1, (b) there is a relationship between immunity to p24 gag and a conserved idiotype, and (c) anti-Sm antibodies can cross-react with p24 gag.
Mechanistic Associations of a Mild Phenotype of Immunodysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome
Authors: Fabrizio De Benedetti, Antonella Insalaco, Antonella Diamanti, Elisabetta Cortis, Flaminia Muratori, Andrea Lamioni, Rita Carsetti, Roberto Cusano, Rita De Vito, Lucia Perroni, Manuela Gambarara, Massimo Castro, Gian Franco Bottazzo, Alberto G. Ugazio
Journal: Clinical Gastroenterology and Hepatology (2006)
Radioselenium in Duodenal Aspirate as an Assessment of Pancreatic Exocrine Function
Authors: G. R. Youngs, J. E. Agnew, G. E. Levin, I. A. D. Bouchier
Journal: BMJ (1971)

A new test of pancreatic exocrine function is described in which radioselenium is measured in duodenal aspirate after an intravenous injection of (75)Se-selenomethionine and administration of a Lundh test meal. Duodenal (75)Se activity gave good separation between normals and subjects with disease of the exocrine pancreas and correlated well with trypsin levels in the aspirate.
Isotopic indices as a measure of inflammation in rheumatoid arthritis.
Authors: H Berry, E C Huskisson
Journal: Annals of the Rheumatic Diseases (1974)

Assessment of inflammation in rheumatoid arthritis (RA) has been studied in several different ways.Hart and Huskisson (1972) considered morning stiffness to be a reflection of inflammation with the disadvantage of being subjective.Boardman and Hart (1967) used proximal interphalangeal joint circumference which is at least objective, but may not be responsive to anti-inflammatory therapy, for example in patients with long-standing or 'burnt-out' disease.Dick, Neufeld, Prentice, Woodburn, Whaley, Nuki, and Buchanan (1970) found that external count rates over single inflamed joints were greater than those over normal joints.They used technetium 99 (99Tc), an isotope with a half-life of 6 hours, and showed reduction in counts after treatment with anti-inflammatory drugs.In a previous study, Huskisson, Berry, Browett, and Balme (1973) showed, no relationship between technetium count over a single joint and any other measurement, arguing that reduction in count rate over a single joint could not be equated with anti-inflammatory effect.These authors also used an index based on counts over both wrists and knees, and in a small study there was a significant correlation with arti- cular index.
Prognostic significance of paraproteinaemia in rheumatoid arthritis.
Authors: C Kelly, G Baird, H Foster, H Hosker, I Griffiths
Journal: Annals of the Rheumatic Diseases (1991)

The incidence of lymphoma and myeloma is increased in rheumatoid arthritis (RA), though the reasons for this are incompletely understood. The predictive value of monoclonal gammopathy in RA for the later development of lymphoproliferative malignancy was assessed. A serum paraprotein was discovered in 23 patients (14 female) with a median age of 58 years and a median duration of RA of six years. The paraprotein was quantified and further investigations, including a bone marrow examination and skeletal survey, were undertaken to study the possible development of a lymphoproliferative disorder. Secondary Sjögren's syndrome was noted in 12 patients. The paraprotein was monoclonal in 21 patients and was classed as IgG (12 cases), IgA (six cases), or IgM (three cases). Biclonal paraproteins were seen in two patients. Free light chains were found in the urine of eight patients. Bone marrow abnormalities were found in 13 subjects. The bone marrow was abnormal in four of six patients with an IgA paraprotein, in two of three with an IgM paraprotein but in only five of 12 patients with an IgG paraprotein. Patients were followed up for a median of four years, and five patients with an abnormal bone marrow developed myeloma, of whom three had an IgA lambda paraprotein. Two other patients developed non-Hodgkin's lymphoma. Extra-articular bone erosions were seen in four patients, three of whom developed myeloma, but the presence of urinary free light chains was not specific for the development of malignancy. Paraproteinaemia in RA indicates monoclonal B cell proliferation and carries a high risk of malignant transformation.
Impairment of the Growth of Plasmodium Falciparum in HbEE Erythrocytes
Authors: Ronald L. Nagel, Carmen Raventos-Suarez, Mary E. Fabry, Herbert Tanowitz, Didier Sicard, Dominique Labie
Journal: Journal of Clinical Investigation (1981)

HbE is a β-chain mutant frequently found among inhabitants of Southeast Asia and surrounding territories. We find that Plasmodium falciparum multiplies more slowly in erythrocytes from individuals homozygous for HbE than in cells from HbA individuals. In contrast, this parasite grows normally in erythrocytes heterozygous for HbE. This is the first direct evidence that suggests what has been suspected on the basis of circumstantial data, that HbE-containing erythrocytes might be advantageous to the carrier in regions with endemic malaria.