tbuckley/cabot-search huggingface dataset:
LOCAL AND SPINAL ANESTHESIA IN GYNECOLOGY AND OBSTETRICS
Authors: GEORGE GELLHORN
Journal: JAMA (1913)

That there is in surgery a field for anesthesias other than by way of the ordinary ether drop-method is so indisputable a premise that I need not waste the few moments at my disposal with argumentation. Suffice it to say that there are no statistics in existence which give a true picture of the alleged harmlessness of the open ether-inhalation narcosis. The exact number of fatalities due to ether will never be known, nor has the rôle of ether in the causation of postoperative complications which endanger life and health of the patients ever been exhaustively considered. few men have the courage to publish their failures, and the medical journals, as Sellheim remarks, "serve as a medium for recounting accidental success rather than the reverse." Of the large number of new modes of anesthesia and modifications of old ones, gynecology has been particullarly benefited by the two methods which I wish to discuss more in detail—local and spinal anesthesia. We know both from clinical observations and anatomic researches that the cervix
Cutaneous carcinoma arising in erosive pustular dermatosis of the scalp
Authors: C. R. LOVELL, R. R. M. HARMAN, J. W. B. BRADFIELD
Journal: British Journal of Dermatology (1980)

Journal Article Cutaneous carcinoma arising in erosive pustular dermatosis of the scalp Get access C. R. LOVELL, C. R. LOVELL Department of Dermatology, Bristol Royal Infirmary, Bristol BS2 8HW Search for other works by this author on: Oxford Academic Google Scholar R. R. M. HARMAN, R. R. M. HARMAN Department of Dermatology, Bristol Royal Infirmary, Bristol BS2 8HW Search for other works by this author on: Oxford Academic Google Scholar J. W. B. BRADFIELD J. W. B. BRADFIELD Department of Histopathology, Bristol Royal Infirmary, Bristol BS2 8HW Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 103, Issue 3, 1 September 1980, Pages 325–328, https://doi.org/10.1111/j.1365-2133.1980.tb07252.x Published: 01 September 1980
Oxygen dependency of epidermal growth factor receptor binding and DNA synthesis of rat hepatocytes
Authors: Tetsuro Hirose, Hiroaki Terajima, Akira Yamauchi, Koichi Kinoshita, Keizou Furuke, Takashi Gomi, Yasuhiro Kawai, Shigeru Tsuyuki, Yoshiaki Nakamura, Iwao Ikai, Takashi Taniguchi, Takashi Inamoto, Yoshio Yamaoka
Journal: Journal of Hepatology (1997)
Autologous Blood Transfusion
Authors: Paul J. Schmidt
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Report H of the American Medical Association's Council on Scientific Affairs<sup>1</sup>will assist greatly in establishing regular usage for autologous blood transfusions. The idea of using your own blood for yourself has long appealed to the prospective recipient and has been advocated by blood bankers. The involvement of the clinician in using the service is necessary for success. There is correction needed in the COUNCIL REPORT about the most practical option, ie, predeposit autologous blood. The Council advocates that donated blood undergo "ABO and Rh group testing, antibody screening, and screening for hepatitis B surface antigen and human T-cell lymphotropic virus type III (HTLV-III) antigen." The last words are in error, since testing for the HTLV-III antigen is not done. The available blood bank test of the donor blood is for the antibody to the HTLV-III antigen, not the antigen itself. In addition, the Council has
Iron-deficiency Anaemia in North-West Indian Soldiers
Authors: M. Hynes, M. Ishaq, T. L. Morris
Journal: BMJ (1945)

Little work has been done on iron-deficiency anaemia in India, and that entirely on the rice-eating labourer. Although anaemia is universal in this class (Macdonald, 1939; Napier and Das Gupta, 1942), it is scarcely improved by iron (Napier and Das Gupta. 1936; Bhave and Bopaiya, 1942). Even heavy hook worm infestation does not always increase anaemia in these people, although labourers with severe anaemia, whether macrocytic or microcytic, are more commonly heavily infested than their fellows (Napier arid Billimoria, 1937; Napier and Das Gupta, 1937: Napier and Majumdar, 1938; Hare, 1940). The discovery, reported in this paper, of widespread mild iron deficiency anaemia in North-West Indian soldiers is therefore of some interest. Material and Methods This work was-carried out in the district of Peshawar (North West Frontier Province) from Feb. to June, 1944. Some 1,400 men from six regiments were examined. All were natives of North-West India, and included Sikhs and Mohammedans from Patiala; Mohammedans, Jats, and Hindus from Rajputana; Mohammedans, Sikhs, Jets, and Gujars from the Punjab; and Pathans. The men were unselecteu, and all were regarded by their units as fit for active service. All had served more than one year, and two-thirds were in their second or third year of service. Only the capillary blood haemoglobin of most of the men was estimated, but full haematocrit determinations were done on venous blood from 341 men. These latter were selected accord ing to their (capillary blood) haemogLobin values, with weight ing of the higher and lower haemoglobin classes; but they were in all other respects representative of the whole group.
Evidence of persistent neurologic injury following thrombotic thrombocytopenic purpura
Authors: Spero R. Cataland, Marie A. Scully, James Paskavitz, Paul Maruff, Leslie Witkoff, Ming Jin, Nicholas Uva, James C. Gilbert, Haifeng M. Wu
Journal: American Journal of Hematology (2010)

Despite improvements in our understanding of the pathophysiology of thrombotic thrombocytopenic purpura (TTP), little data exist regarding the long-term sequelae following a diagnosis of TTP. We present the results of a comprehensive evaluation of neurologic injury that included a magnetic resonance imaging (MRI), a neurocognitive testing, and an evaluation of health-related quality of life. Twenty-seven patients with a history of idiopathic TTP functioning normally in their activities of daily living were recruited from existing patient cohorts at both the Ohio State University (n 5 12) (Columbus) and the University College London Hospitals (n 5 15) (London, UK). Nine of 23 (39%) of the MRI studies were abnormal; 17/27 (63%) patients demonstrated neurocognitive impairment, particularly in tests of visual learning and memory. Health-related quality of life scores were also significantly lower than age- and gender-matched US norms for both the composite mental component score and physical component score. These data suggest that the prevalence of neurologic findings in TTP patients in remission is quite high and is largely undetected by routine clinical evaluations. Further longitudinal study will be required to define the risk for neurologic injury and the long-term prognosis in patients previously diagnosed with TTP.
Evolution of Abnormalities in Left Ventricular Function After Acute Myocardial Infarction.
Authors: M. I. Broder
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Evolution of Abnormalities in Left Ventricular Function After Acute Myocardial Infarction.M. I. Broder, M.D., E. Rodriguera, M.D., J. N. Cohn, M.D., F.A.C.P.M. I. Broder, M.D., E. Rodriguera, M.D., J. N. Cohn, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-817_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe evolution of hemodynamic changes in acute myocardial infarction was investigated in 12 patients using left ventricular catheterization and ultrasoundcardiography. All patients had rales and ventricular gallops at the initial study within 24 hr after acute myocardial infarction (study 1) but showed no evidence of heart failure at restudy 3 weeks later (study 2). Cardiac index rose from an average of 2.50 liters/min/m2in study 1 to 3.15 liters/min/m2in study 2 (P< 0.01), and right atrial pressure fell from an average of 9.4 mm Hg in study 1 to 5.3 mm Hg in study 2 (P< 0.002).... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byShock in acute myocardial infarction: Evolution of physiologic therapyBiventricular dynamics during quantitated anteroseptal infarction in the porcine heartRelationship of Pulmonary Artery to Left Ventricular Diastolic Pressures in Acute Myocardial InfarctionHeart Failure Complicating Acute Myocardial InfarctionIMPROVED LEFT VENTRICULAR FUNCTION DURING NITROPRUSSIDE INFUSION IN ACUTE MYOCARDIAL INFARCTION 1 May 1971Volume 74, Issue 5Page: 817-818KeywordsAcute myocardial infarctionCatheterizationHeart failureHemodynamicsLongitudinal studies Issue Published: 1 May 1971 PDF downloadLoading ...
Comparison of the Acute Cardiopulmonary Effects of Oral Albuterol, Metaproterenol, and Terbutaline in Asthmatics
Authors: James D. Wolfe
Journal: JAMA (1985)

The acute cardiopulmonary effects of oral albuterol, 4 mg, metaproterenol sulfate, 20 mg, and terbutaline sulfate, 5 mg, were compared over eight hours in 20 moderate to severe asthmatics. The magnitude and time course of bronchodilation following albuterol and terbutaline were comparable. Albuterol and terbutaline had a duration of action of at least eight hours and produced significantly greater bronchodilation than metaproterenol from six to eight hours. Metaproterenol produced a greater degree of bronchodilation than albuterol and terbutaline 30 minutes after drug dosing. Significantly fewer patients receiving albuterol experienced one or more central nervous system or musculoskeletal side effects than patients receiving terbutaline. These findings imply possible therapeutic advantages of oral albuterol and terbutaline with respect to dosing frequency, while the more rapid onset of oral metaproterenol suggests that it may have an advantage when used on an as-needed basis.
Why believe in beliefs?
Authors: Mark H. Bickhard
Journal: Behavioral and Brain Sciences (2004)

A central pillar of Carpendale &amp; Lewis's (C&amp;L's) argument is Wittgenstein's later work on language. I suggest that this support is not as strong as might be wished, and offer an alternative approach to their conclusion that language learning, especially of folk psychology, involves a socially embedded constructivism.
Lehrbuch der biographischen Analyse: Theorie und Praxis lebensgeschichtlich orientierter Krankheitsbetrachtung und Krankenbehandlung
Authors: H. L. Gordon
Journal: JAMA (1964)

Karl Jaspers, in his<i>Allgemeine Psychopathologie</i>, said that every disease leads to a biography and every physician should be a biographer. The biographical anamnesis seeks to uncover the original and acquired causes, conditions, and dispositions acting in the patient and the environment. In Freudian psychoanalysis the biography consists primarily of a description of the dreams. Organic diseases have no contraindication for a sickness biography, for the biographical anamnesis can contribute to the understanding of bodily and mental shortcomings. According to Clauser, life reactions to illness are divided into coincidental, dissident, and divergent; all that is abnormal in human life, including birth anomalies, and physical, emotional, and moral factors are all interrelated. On one side of longitudinal charts, the author displays human anomalies and relates them, on the other side of the chart, to events in the life of the individual. The relationship is sometimes fantastic and arbitrary and cannot always
ABC of major trauma. Radiological assessment--I.
Authors: N M Perry, M D Lewars
Journal: BMJ (1990)

The mainstay of radiological investigation of trauma in the resuscitation room is the plain radiograph, which is available in all accident and r ~i emergency departments.Many immediate management decisions can be made with the aid of such radiographs, which show possible causes of cardiorespiratory compromise and detail any major bone or soft tissue injury.The development of pneumothorax, haemothorax, or early signs of aortic rupture may be clearly shown.Radiological investigation should not interfere with the mechanics of resuscitation or be allowed to delay appropriate surgery.The experienced radiographer is an invaluable member of the emergency team.He or she can advise on the effects that positioning and resuscitation procedures may have on the images produced and give guidance as to possible delays caused by various radiographic techniques.Unnecessary exposure of the patient and, particularly, of members of staff to damaging ionising radiation must be avoided.Every radiograph should have a purpose.The quality of each image will depend on the time and effort taken to produce it.Full radiological evaluation may be deferred in patients with peripheral injuries that are not life threatening, particularly if there are other patients with trauma to be assessed.Two important-considerations in cases of major trauma are whether recognised focal injury has had hidden consequences and whether there is clinically occult damage that has been signalled early by radiography.For example, a rib or sternal fracture may be clinically quite apparent, but there may be an underlying haemopericardium; likewise a pneumothorax or
Livedo reticularis and neurological lesions
Authors: D.J. THOMAS, J.D.T. KIRBY, K.E. BRITTON, D.J. GALTON
Journal: British Journal of Dermatology (1982)

SUMMARY

Two patients with extensive livedo reticularis have developed multiple severe neurological lesions over a 6-year period. The possible pathogenesis is discussed.



The presence of livedo reticularis has been described in conjunction with many diseases (Rook, Wilkinson & Ebling, 1979). A rare association between this condition and neurological syndromes has also been reported (Sneddon, 1965; Quimby & Perry, 1980). We report two cases which add further support to this association.
The SUPPORT project and improving care for seriously ill patients
Authors: T. J. Prendergast
Journal: JAMA (1996)

To the Editor.  —The investigators of the Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments (SUPPORT) 1 are to be commended for meticulous research and their commitment to improving the care of seriously ill patients. Unfortunately, SUPPORT was based on at least 3 assumptions, each of which can be questioned.  Their first assumption is that patients want information to compute expected values and make a maximally informed choice. In SUPPORT, patients and their families reported satisfaction with their care, even while they noted that physicians had failed to discuss prognosis. The medical literature suggests that patients seek information without necessarily wanting to make a decision; when they do wish to decide about end-of-life issues, they may not be computing expected values. 2-4 Information sharing is not an adequate model for understanding patient preferences, and it is a poor strategy for changing outcomes.  Another assumption is that
Abstract 1099: Aza-derivatives of resveratrol are potent inhibitors of macrophage migration inhibitory factor (MIF)
Authors: Yoshihiko Fujita, Rafiqul Islam Islam, Hideharu Kimura, Kazuko Matsumoto, Kazuyuki Furuta, Tomoyuki Nagai, Kanae Kudo, Hiroyasu Kaneda, Daisuke Tamura, Kazuko Sakai, Keiichi Aomatsu, Tokuzo Arao, Tadashi Okawara, Kazuto Nishio
Journal: Cancer Research (2011)

Abstract Resveratrol (3, 4’, 5-trihydroxy-trans-stilbene), a natural phytoalexin found in grapes and wine, has an anti-proliferative activity in human-derived cancer cells. In our study, we used a conventional condensation reaction between aldehydes and amines to provide a number of aza-resveratrol (3, 4’, 5-trihydroxy-trans- aza-stilbene) derivatives in an attempt to screen for compounds with resveratrol's action but with increased potency. Aza-resveratrol and its hydroxylated derivative (3, 4, 4’, 5-tetrahydroxy-trans- aza-stilbene) showed a more enhanced anti-proliferative effect than resveratrol in an MCF-7 breast carcinoma cell line. To identify the cellular targets of the aza derivatives of resveratrol, we conjugated the latter aza-stilbene compound with epoxy-activated agarose and performed an affinity purification. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, was identified as a major target protein in MCF-7 cell lysates using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS). The aza-resveratrol and its hydroxylated derivative, but not resveratrol, were also found to be potent inhibitors of MIF tautomerase activity, which may be associated with their inhibitory effects on MIF bioactivity for cell growth. Such inhibitors may lead to the development of drugs for the treatment of cancer and, possibly, inflammatory and autoimmune diseases. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1099. doi:10.1158/1538-7445.AM2011-1099
New Directions in the Treatment of Acute Lymphoblastic Leukemia in Children
Authors: Alvin M. Mauer
Journal: New England Journal of Medicine (1986)

The era of effective chemotherapy for acute lymphoblastic leukemia in children began almost four decades ago with an article in the Journal in which Sydney Farber and his coworkers1 described their results with aminopterin. In the two decades that followed, other drugs were introduced and found to be effective as single agents and even more effective in combination. By the beginning of the 1970s, combined drug therapy with central nervous system prophylaxis was resulting in long-term disease-free survival and apparent cure in more than half the cases of acute lymphoblastic leukemia in children.2 For his important contributions to this accomplishment, . . .
BIVALIRUDIN VERSUS HEPARIN WITH OR WITHOUT GLYCOPROTEIN IIB/IIIA INHIBITORS IN STEMI PATIENTS UNDERGOING PRIMARY PCI: A POOLED ANALYSIS OF PATIENT-LEVEL DATA FROM THE HORIZONS-AMI AND EUROMAX TRIALS
Authors: Philippe Gabriel Steg, Roxana Mehran, Patrick Goldstein, Bernhard Witzenbichler, Arnoud van't Hof, Giulio Guagliumi, Christian W. Hamm, Philippe Genereux, Peter Clemmensen, Helen Parise, Stuart Pocock, Bernard J. Gersh, Debra Bernstein, Efthymios N. Deliargyris, Gregg W. Stone, Hôpital Bichat
Journal: Journal of the American College of Cardiology (2014)
Juvenile Congenital Pernicious Anemia
Authors: Denis R. Miller, Gerald E. Bloom, Richard R. Streiff, Albert F. LoBuglio, Louis K. Diamond
Journal: New England Journal of Medicine (1966)

JUVENILE "congenital" pernicious anemia is characterized by vitamin B12 deficiency appearing in early life as the result of a congenital lack of gastric intrinsic factor with no other apparent abnormality of the stomach or its secretions. This is in contrast to the far more frequent adult form of pernicious anemia, in which achlorhydria and gastric atrophy are uniformly present. Furthermore, serum antibodies to intrinsic factor and gastric parietal cells, commonly detected in the adult syndrome, are conspicuously absent in the patients with juvenile "congenital" pernicious anemia.1 , 2 The juvenile "congenital" form resembles the adult form, however, in that the defective . . .
1005. Expression of Porcine α(1-3)galactosyltransferase in Non-Human Primate Hematopoietic Progenitors Following Simian Immunodeficiency Virus Mediated Gene Transfer
Authors: Lorenzo Benatuil, John Iacomini
Journal: Molecular Therapy (2006)

Background. Preformed anti-donor antibodies are believed to play a significant role in chronic allograft rejection. We have shown that genetic engineering of autologous bone marrow stem cells, can be used to establish B cell tolerance in mice. Here we examined the ability of simian immunodeficiency virus vector (SIV) to transduce hematopoietic CD34+ progenitor cells from non-human primates and achieve expression of αGT in these cells. Methods. CD34+ progenitors were purified from bone marrow (BM) of Rhesus macaques. After 36 h of stimulation with SCF, Flt3-L, and hTPO, cells were exposed to amphotropic SIV vector carrying the gene encoding the αGT enzyme (SIV-αGT), or enhanced green fluorescent protein (SIV-GFP) to achieve different multiplicities of infection (MOIs) for 24 h. After transduction, CD34+ cells were suspended in methylcellulose medium to perform Colony-forming unit (CFU) assays. Cell surface staining and flow cytometry were used to analyze αGal epitopes or GFP expression on the surface of transduced CD34+ cells as well as in CFUs. Results. CD34+ progenitors were readily transduced with amphotropic enveloped SIV vector carrying the gene encoding either αGT or GFP. Infection of CD34+ cells with SIV-αGT using MOI of 1, 3, 5 or 10 resulted in 35.6 ± 2.9%, 50.5 ± 5.8%, 55.6 ± 5.8% and 58.8 ± 5.4% of cells expressing αGal, respectively. Infection of CD34+ cells with SIV-GFP using an MOI of 1, 3, 5 or 10 resulted in 47.9 ± 2.4%, 55.4 ± 6.3%, 67.4 ± 2.4% and 76.0 ± 6.6% of cells expressing GFP, respectively. MOIs greater than 5 did not augment the transduction efficiency and MOIs greater than 10 decreased viability. Infection with SIV-αGT for more than 24 h did not improve the transduction efficiency. In all cases, mock-transduced cells remained negative for αGal or GFP expression. There was no significant difference in the numbers, frequency or size of CFUs observed following infection with both vector or mock-transduced cells. The transduction efficiency of CD34+ cells with SIV-αGT was similar to the frequency of CFUs expressing αGal. Conclusion. These data demonstrate that rhesus macaque CD34+ BM cells can be efficiently transduced with amphotropic enveloped SIV vector carrying the gene encoding αGT. The transduction efficiency was similar to that observed using viruses carrying the marker gene GFP. Using the transduction conditions described, the majority of transduced cells expressing αGal or GFP remained CD34+. Knowing that the SIV vectors represent a reliable system to evaluate gene transfer in a non-human primate, it may be possible to use SIV-αGT vector and genetic engineering of BM in primates in order to establish expression of and tolerance to αGal. This approach could be an important way to avoid preformed anti1-donor antibody response in allotransplantation.
Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver
Authors: Jan Plock, Steffen Frese, Adrian Keogh, Sonja Bisch-Knaden, Erick Ayuni, Nadia Corazza, Christian Weikert, Stephan Jakob, Dominique Erni, Jean-François Dufour, Thomas Brunner, Daniel Candinas, Deborah Stroka
Journal: Journal of Hepatology (2007)
The Politics of Risk: A Human Rights Paradigm for Children’s Environmental Health Research
Authors: Maura A. Ryan
Journal: Environmental Health Perspectives (2006)

A human rights paradigm for environmental health research makes explicit the relationship between poor health and poverty, inequality, and social and political marginalization, and it aims at civic problem solving. In so doing, it incorporates support for community-based, participatory research and takes seriously the social responsibilities of researchers. For these reasons, a human rights approach may be better able than conventional bioethics to address the unique issues that arise in the context of pediatric environmental health research, particularly the place of environmental justice standards in research. At the same time, as illustrated by disagreements over the ethics of research into lead abatement methods, bringing a human rights paradigm to bear in the context of environmental health research requires resolving important tensions at its heart, particularly the inescapable tension between ethical ideals and political realities.
Abstract 1661: Pacemaker Or Implantable Cardioverter-defibrillator Related Infection : Prospective Evaluation Of Diagnosis Criteria And Of An Algorithm Of Management.
Authors: Didier Klug, Frederic Wallet, Christelle Marquie, Anne-Sophie Polge, Georges Fayad, Rene Courcol, Salem Kacet
Journal: Circulation (2007)