tbuckley/cabot-search huggingface dataset:
Sulphasalazine in ankylosing spondylitis: a double blind controlled study in 60 patients.
Authors: M Dougados, P Boumier, B Amor
Journal: BMJ (1986)

Sulphasalazine has been reported to be effective in ankylosing spondylitis with peripheral arthritis, but its efficacy in spondylitis is unknown. Thus 60 patients with active ankylosing spondylitis without peripheral arthritis or gastrointestinal symptoms were randomly allocated to one of two therapeutic groups. One group received 2 g sulphasalazine daily for six months and the other a placebo. Thirteen patients (six given placebo and seven given sulphasalazine) dropped out of the trial and were considered to be treatment failures. After six months9 follow up efficacy was rated as good or very good by 15 of the 30 patients given sulphasalazine and by only six of the 30 given placebo (p less than 0.02). Furthermore, in the patients given sulphasalazine the daily consumption of non-steroidal anti-inflammatory drugs, functional index, and plasma IgG concentrations had fallen significantly. These data suggest that sulphasalazine may be a safe and effective treatment for spondylitis in ankylosing spondylitis.
Paracrine Factors of Human Fetal MSCs Inhibit Liver Cancer Growth Through Reduced Activation of IGF-1R/PI3K/Akt Signaling
Authors: Yulyana Yulyana, Ivy A W Ho, Kian Chuan Sia, Jennifer P Newman, Xin Yi Toh, Berwini B Endaya, Jerry K Y Chan, Massimiliano Gnecchi, Hung Huynh, Alexander Y F Chung, Kiat Hon Lim, Hui Sun Leong, Narayanan Gopalakrishna Iyer, Kam Man Hui, Paula Y P Lam
Journal: Molecular Therapy (2015)

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death in the world. The multikinase inhibitor sorafenib only demonstrated marginal improvement in overall survival for advanced disease prompted the search for alternative treatment options. Human mesenchymal stem cells (MSCs) have the ability to home to tumor cells. However, its functional roles on the tumor microenvironment remain controversial. Herein, we showed that conditioned media derived from human fetal MSC (CM-hfMSCs) expressed high level of the insulin growth factor binding proteins IGFBPs and can sequester free insulin-like growth factors (IGFs) to inhibit HCC cell proliferation. The inhibitory effect of IGFBPs on IGF signaling was further evident from the reduction of activated IGF-1R and PI3K/Akt, leading eventually to the induction of cell cycle arrest. We also demonstrated that CM-hfMSCs could enhance the therapeutic efficacy of sorafenib and sunitinib. To the best of our knowledge, this is the first report to show that CM-hfMSCs has a tumor-specific, antiproliferative effect that is not observed with normal human hepatocyte cells and patient-derived matched normal tissues. Our results thus suggest that CM-hfMSCs can provide a useful tool to design alternative/adjuvant treatment strategies for HCC, especially in related function to potentiate the effects of chemotherapeutic drugs.
Expanded operational concept of high risk groups and its role in standard setting.
Authors: E J Calabrese
Journal: Environmental Health Perspectives (1983)

The role of the knowledge of high risk groups in the standard-setting process is examined. The overall conclusion is that many potential high risk segments of the population have not been studied adequately and that this deficiency in our knowledge markedly reduces the ability of decision makers to derive appropriate regulatory decisions by either ignoring the potential health effects or applying potentially excessive and expensive safety factors.
Decreased cardiovascular and extrahepatic cancer-related mortality in treated patients with mild HFE hemochromatosis
Authors: Edouard Bardou-Jacquet, Jeff Morcet, Ghislain Manet, Fabrice Lainé, Michèle Perrin, Anne-Marie Jouanolle, Dominique Guyader, Romain Moirand, Jean-François Viel, Yves Deugnier
Journal: Journal of Hepatology (2014)
Treatment of Dumping Syndrome
Authors: S. Bank, P. Keller, I. N. Marks, I. G. O'Reilly
Journal: BMJ (1964)

coincidental, must result from a failure of aseptic techniques.Any interference in a patient with a foetal death has some risk, and this risk must be weighed against that of conservative treat- nent.At a scientific meeting of the Royal College of Obstetricians and Gynaecologists Dr. Geoghegan, of Dublin, reported a maternal death resulting from amniotic embolus immediately after abdominal amni- otomy in a patient with polyhydramnios; this must also be recognized as a rare but definite risk of the procedure.If induction of labour is thought necessary in a patient with foetal death intravenous oxytocin is probably the safest initial procedure.How- ever, induction may fail in these circum- stances, and it would still seem reasonable to use intra-amniotic hypertonic glucose or saline rather than prolong oxytocin therapy for more than two days.-Weare, etc.,
Embryo Specimens Wanted.
Authors: C. M. Jackson
Journal: JAMA (1905)

Columbia, Mo., Sept. 26, 1905. <h3>To the Editor:</h3> —I am making a collection of human embryos, which are preserved permanently for research work in human embryology. Any specimens (especially of the earlier stages), which your readers may be able to contribute would be thankfully received. The best general preservative is 10 per cent. formalin or the strongest alcohol.
Growth Properties of Cardiac Stem Cells Are a Novel Biomarker of Patients’ Outcome After Coronary Bypass Surgery
Authors: Domenico D’Amario, Antonio M. Leone, Antonio Iaconelli, Nicola Luciani, Mario Gaudino, Ramaswamy Kannappan, Melissa Manchi, Anna Severino, Sang Hun Shin, Francesca Graziani, Gina Biasillo, Andrea Macchione, Costantino Smaldone, Giovanni Luigi De Maria, Carlo Cellini, Andrea Siracusano, Lara Ottaviani, Massimo Massetti, Polina Goichberg, Annarosa Leri, Piero Anversa, Filippo Crea
Journal: Circulation (2013)

The efficacy of bypass surgery in patients with ischemic cardiomyopathy is not easily predictable; preoperative clinical conditions may be similar, but the outcome may differ significantly. We hypothesized that the growth reserve of cardiac stem cells (CSCs) and circulating cytokines promoting CSC activation are critical determinants of ventricular remodeling in this patient population.To document the growth kinetics of CSCs, population-doubling time, telomere length, telomerase activity, and insulin-like growth factor-1 receptor expression were measured in CSCs isolated from 38 patients undergoing bypass surgery. Additionally, the blood levels of insulin-like growth factor-1, hepatocyte growth factor, and vascular endothelial growth factor were evaluated. The variables of CSC growth were expressed as a function of the changes in wall thickness, chamber diameter and volume, ventricular mass-to-chamber volume ratio, and ejection fraction, before and 12 months after surgery. A high correlation was found between indices of CSC function and cardiac anatomy. Negative ventricular remodeling was not observed if CSCs retained a significant growth reserve. The high concentration of insulin-like growth factor-1 systemically pointed to the insulin-like growth factor-1-insulin-like growth factor-1 receptor system as a major player in the adaptive response of the myocardium. hepatocyte growth factor, a mediator of CSC migration, was also high in these patients preoperatively, as was vascular endothelial growth factor, possibly reflecting the vascular growth needed before bypass surgery. Conversely, a decline in CSC growth was coupled with wall thinning, chamber dilation, and depressed ejection fraction.The telomere-telomerase axis, population-doubling time, and insulin-like growth factor-1 receptor expression in CSCs, together with a high circulating level of insulin-like growth factor-1, represent a novel biomarker able to predict the evolution of ischemic cardiomyopathy following revascularization.
Enhancement of ultraviolet-induced apoptosis by NF-kappaB decoy oligonucleotides
Authors: S. Yokoyama, H. Nakano, T. Yamazaki, K. Tamai, K. Hanada, G. Takahashi
Journal: British Journal of Dermatology (2005)

A decoy strategy utilizing oligonucleotides (ODN) containing the specific binding sequence of a certain transcription factor has been developed and is considered to be a potential new class of antigene therapy. However, the application of this new therapeutic modality to skin diseases has not been fully documented.The aim of this work was to examine the effects of the nuclear factor (NF)-kappaB decoy ODN on UV-elicited skin change.Mouse keratinocyte Pam 212 cells were transfected with NF-kappaB decoy ODN to examine the effects of the decoy ODN on ultraviolet (UV) B-induced apoptosis. Tape-stripped rat dorsal skin was treated with an ointment containing NF-kappaB decoy ODN for the examination of the in vivo impact of the decoy ODN on sunburned cell (SBC) formation and UVB erythema.NF-kappaB decoy ODN specifically induced apoptosis of Pam 212 cells and SBC formation was significantly enhanced by topical NF-kappaB decoy ODN ointment, while UV-induced erythema was not affected.These data suggest that enhancement of UV-induced apoptosis by NF-kappaB decoy ODN may play a cancer-preventive role by further eliminating photodamaged keratinocytes.
In multiple myeloma, bone‐marrow lymphocytes harboring the same chromosomal abnormalities as autologous plasma cells predict poor survival
Authors: Carina S. Debes Marun, Andrew R. Belch, Linda M. Pilarski
Journal: American Journal of Hematology (2012)

Chromosomal abnormalities in plasma cells (PCs) from multiple myeloma (MM) provide a clonal signature to identify malignant cells. BM-lymphocytes from MM aspirates, defined by stringent criteria, were screened for the same chromosomal abnormalities as autologous PCs, including translocations, deletions, and amplifications. For 200 MM patients, we evaluated BM mononuclear cells to identify lymphocytes and autologous PCs on the same slide, followed by interphase fluorescence in situ hybridization to characterize their chromosomal abnormalities. Of all patients having a given chromosomal abnormality(s) in PCs, 45% showed that same abnormality(s) in 2-37% (median = 5%) of BM-lymphocytes. Most translocations, amplifications, and deletions found in MM PCs were also detected in lymphocytes, above the healthy-donor "cut-off." In patients having chromosomally abnormal CD20(-) PCs, chromosomally abnormal lymphocytes were found among CD20+ cells confirming them as B cells. Exceptions were amplification of 1q21 or p53 deletion, which characterize PCs but were undetectable in BM-lymphocytes, suggesting that processes leading to these abnormalities may be exclusive to PCs. For a set of 75 patients whose BM-lymphocytes and PCs were analyzed by all six probe sets, 58% of those with abnormal PC also had abnormal BM-lymphocytes harboring from one to five different abnormalities. Confirming the clinical significance of chromosomally abnormal BM-lymphocytes, MM patients having abnormalities in both lymphocytes and PC had significantly worse survival than those with abnormalities only in PC (HR = 2.68). The presence of at least one chromosomal abnormality in BM-lymphocytes appears to have greater clinical significance than particular abnormalities. Chromosomally abnormal BM-lymphocytes correlate with poor outcome and by extrapolation with more aggressive disease.
Abstract 4368: Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses
Authors: Suvendu Das, Eliana Sarrou, Melanie Cassella, Nikki Feirt, Mihaela Skobe
Journal: Cancer Research (2012)

Abstract The lymphatic vessels are thought to contribute to metastasis primarily by serving as a transportation system. It is widely believed that tumor cells enter lymph nodes passively, by the flow of lymph. Here, we demonstrate that lymph node lymphatic sinuses control tumor cell entry into the lymph node. In vitro, tumor migration to lymphatic endothelium (LECs) was inhibited by blocking CCR8 or CCL1. Recombinant CCL1 promoted migration of CCR8+ tumor cells. Pro-inflammatory mediators TNF-α, IL-1α and LPS increased CCL1 production by LECs as well as tumor cell migration to LECs. Blocking studies showed that CCL1 is a key molecule mediating tumor cell chemotaxis to inflamed lymphatic endothelium. In mouse and human tissues CCL1 protein was detected in lymph node lymphatic sinuses, but not in the peripheral lymphatics. In addition, CCR8 was strongly expressed by human malignant melanoma. In a mouse model, blocking CCR8 function decreased lymph node metastasis. Notably, inhibition of CCR8 led to the arrest of tumor cells in the collecting lymphatic vessels at the junction with the lymph node subcapsular sinus. These data identify a novel function for CCL1/CCR8 in metastasis and lymph node LECs as a critical check-point for entry of metastases into the lymph nodes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4368. doi:1538-7445.AM2012-4368
Heating Polyunsaturated Fats
Authors: EDWARD R. PINCKNEY
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 October 1970Heating Polyunsaturated FatsEDWARD R. PINCKNEY, M.D., F.A.C.P.EDWARD R. PINCKNEY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-4-657_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: For the past 2 months (May and June 1970) the ANNALS has noted in its Medical News section the series of publications prepared by the National Heart and Lung Institute entitled "Dietary Management of Hyperlipoproteinemia."In these publications, designed to help physicians guide changes in diet for persons with high levels of cholesterol (or other fats in the blood) as measured by laboratory tests, there are specific statements to the effect that "polyunsaturated" fats (or oils) should be used in "broiling, baking, or frying . . ." and in "popping corn." It does seem to me that... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Box P Beverly Hills, Calif. 90213 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe potential toxicity of excessive polyunsaturates 1 October 1970Volume 73, Issue 4Page: 657-658KeywordsDietFatsHeartHematologic testsHypercholesterolemiaLaboratory testsLungsOils Issue Published: 1 October 1970 PDF DownloadLoading ...
Aetiology of Gravitational Ulcers of the Leg
Authors: S. T. Anning
Journal: BMJ (1949)

The term  gravitational ulcer, first used by Dickson Wright (1931), refers to those chronic ulcers which occur on the lower half of the leg associated with one or more of the following: oedema, cyanosis, induration, sclerosis, pigmentation, loss of hair, eczema, and varicose veins of the affected limb. These are signs of chronic impairment of the venous drainage of the leg. The importance of gravity in the cause of this condition was stressed by Brodie (1846)* and by Hilton (1863). Brodie called such ulcers  varicose, and they have long been thought to be due to varicose veins. Gay (1868) was probably the first to show, by clinical observation and careful dissection, that many were due to obstruction of trunk veins, deep and superficial, and that varicose veins often play no part. Gay's work seems to have been forgotten or has been neglected, and the view that varicose veins are the main or only cause has persisted (McPheeters, 1928). Dickson Wright (1931) and Homans (1939) held this opinion, though both believed that some gravitational ulcers were due to thrombosis of deep veins. However, in a series of 432 patients with leg ulcers Birger (1941) found that throm bosis was the chief factor. Nilz?n (1945) thought that cer tainly 41% or possibly 56% of such ulcers were caused by previous thrombosis, Bauer (1946) that 80-90% and Birger (1947) that 40% were due to this cause. The belief that varicose veins play a major part in the aetiology of these ulcers has affected treatment, which until the last few years has concentrated attention on such superficial varicose veins as might be present. Allen, Barker, and Hines (1946) considered that chronic venous insufficiency or stasis of the venous blood flow was due to obstruction of one of the main veins of the limb, particularly the ilio-femoral, as the result of thrombo phlebitis, neoplastic invasion, or external pressure ; incom petency of valves of the ilio-femoral vein resulting from thrombophlebitis without permanent obstruction of the vein ; or varicose veins of primary type (i.e., developing spontaneously), particularly those of long standing or considerable extent.
Edge of Smile or Brink of Guffaw? Clergyman/Linebacker Contemplates Draft of 1516-Reply
Authors: M. Therese Southgate
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology of illness during the super 14 rugby tournament - a prospective cohort study
Authors: M Schwellnus, W Derman, M Lambert, C Redhead, T Page
Journal: British Journal of Sports Medicine (2011)

Background There is some evidence suggesting that medical illness can account for a significant proportion of consultations by a team physician travelling with a group of elite athletes. The Super 14 Rugby tournament is conducted over a 3 months period and involves intercontinental travel. Objective The purpose of this study was to determine the incidence of medical illness in rugby players participating in the 2010 Super 14 Rugby tournament. Setting 2010 Super 14 Rugby tournament. Participants A cohort of elite rugby players from eight Super 14 rugby teams (average squad size of 30 players) was recruited. Assessment All players completed a pre-competition questionnaire pertaining to personal details, training history, personal general medical history and medication. Players were then followed daily over the 3 month competition period (total of 20 836 player days). Team physicians completed a daily medical illness and treatment log using a newly developed illness coding system based on the ICD10 codes (100% compliance). Information included the daily squad size and illness details (system affected, final diagnosis, symptoms, treatment and training/match days lost). Main outcome measurement Incidence of illness (illness per 1000 player days). Results The overall incidence of illness in the cohort was 21.4 per 1000 player days. The highest incidence (per 1000 player days) of illness by system was in the respiratory system (6.6), gastro-intestinal system (5.9) and the dermatological system (4.7). Respiratory tract illness accounted for 31% of all illness followed by the gastro-intestinal system (28%) and the dermatological system (22%). Conclusion Medical illness is common in elite rugby players participating in an international tournament over a 3-month period. Respiratory tract, gastro-intestinal tract and dermatological illness accounted for over 80% of these illnesses.
Reduction of Dislocated Shoulders Using Methocarbamol
Authors: Raymond G. Tronzo
Journal: JAMA (1963)

THE SUCCESSFUL CLOSED REDUCTION of a traumatic dislocation of the hip using injectable methocarbamol as a muscle relaxant was reported previously.<sup>1</sup>The interest inspired led to the present study in which an attempt was made to assess the therapeutic usefulness of an injectable muscle relaxant as an adjunct in the closed reduction of dislocated shoulders. <h3>Methods and Materials</h3> A total of 49 dislocation cases are reported in this paper. For the sake of uniformity, only cases involving dislocations of the shoulder were included in the study, and all cases with associated fracture other than a simple undisplaced tuberosity fracture were excluded on the grounds of this obviously uncontrollable variable. The injury was found predominately in males 34- to 50-yr-old. Although the over-all age range of patients in this study was from 16 to 81 yr, the upper age limit may be distorted due to the large number of city
Viral illness and the postpericardiotomy syndrome. A prospective study in children.
Authors: M A Engle, J B Zabriskie, L B Senterfit, W A Gay, J E O'Loughlin, K H Ehlers
Journal: Circulation (1980)

Postoperative fever and pericardial-pleural reaction, designated postpericardiotomy syndrome (PPS), is a common complication of cardiac surgery involving entry into the pericardium. To determine whether the etiology of PPS is viral or immunologic, we undertook a prospective, triple-blind study of consecutive long-term survivors of intrapericardial surgery in the pediatric age group. We evaluated clinical evidence of syndrome and concurrent appearance of antiheart antibody (AHA) by indirect immunofluorescence and antiviral antibody (AVA) by complement fixation in sera preoperatively and serially postoperatively. Incidence of PPS was 27% overall in 400 subjects, but only 3.5% in infants younger than 2 years of age. AHA in high titer appeared in all patients with PPS. A fourfold or greater rise in titer to AVA was found in 70% of these but in only 5% of those with negative AHA and no PPS. AVA rise, tested in 280 consecutive patients, was to no single one of the eight viruses studied (adenovirus, cytomegalovirus, and coxsackievirus B 1-6). Instead, the rise and fall, consistent with antiviral response to a recent infection, was exhibited usually to one but occasionally to two or more viruses, and the viral prevalence changed from year to year, as did that in the community. The study suggests that concurrent fresh or reactivated viral illness plays a role in triggering the immunologic response that characterizes the PPS.
Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-β–treated alloreactive T cells that do not induce graft-versus-host disease
Authors: Vassiliki A. Boussiotis, Zong-Ming Chen, Jay C. Zeller, William J. Murphy, Alla Berezovskaya, Satwant Narula, Maria G. Roncarolo, Bruce R. Blazar
Journal: Blood (2001)
The importance of gene-centring microarray data
Authors: Therese Sørlie, Eldrid Borgan, Simen Myhre, Hans Kristian Vollan, Hege Russnes, Xi Zhao, Gro Nilsen, Ole Christian Lingjærde, Anne-Lise Børresen-Dale, Einar Rødland
Journal: The Lancet Oncology (2010)