tbuckley/cabot-search huggingface dataset:
The Pill Bottle Desiccant and Noncompliance
Authors: Jerome K. Roth
Journal: JAMA (1980)

<h3>To the Editor.—</h3> The article by Muhletaler et al (1980;243:1921) describes serious consequences (partial gastrointestinal obstruction) of a phenomenon that, according to our recent clinical experience, may be more widespread than realized. Among the vast number of patients treated in the outpatient urology clinics at Charity Hospital of New Orleans, occasionally a patient will urgently require a specific medication. The physician may harbor serious doubt as to whether the patient will, in fact, fill the prescription. Noncompliance may be because of either monetary reasons or lack of understanding of the scope of his or her illness. In these cases, samples of the particular medication are often given to the patient. On several occasions during the past few months, patients have returned for follow-up stating strict compliance with their dosage schedules, yet not having used all of the medication given to them for the particular period. It was only after one
Uncomplicated Exudative Synovitis
Authors: E. C. ROBICHAUX
Journal: Annals of Internal Medicine (1928)

Article1 January 1928Uncomplicated Exudative Synovitis(With Report of Two Cases)E. C. ROBICHAUX, M.D.E. C. ROBICHAUX, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-7-513 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptYour attention is invited to the report of two rare types of monoarticular exudative synovitis. Neither was intimately associated with acute or chronic arthritis of whatever kind, nor the immediate result of acute or chronic traumatism. One was definitely intermittent and recurrent in type, the other occurred but the one time. The etiology in both is admittedly obscure.Case I. M. L.; aged 40; weight 220; manufacturer. Admitted October 1926 complaining of swollen knee. He was seen in three separate attacks at long intervals between. Despite the years which separated them, each attack had the main characteristics of the other....References(1) DANCE : Archives générales de Médecine, 1831, p. 190. Google Scholar(2) PERRIN M: Un cas curieux de contracture partielle intermittente, et épanchement de sérosite dans plusieurs articulations, J. de Med., 1845, p. 82. Google Scholar(3) MACLELLAND R: Two cases of intermittent Hydrops articulorum, Lancet 1:463, 1919. CrossrefGoogle Scholar(4) BENDA T: Intermitterende Gelenk Wassersucht. Allgem. Med. Central-Ztg. 106:483, 1900. Google Scholar(5) OSLER W: Principles and Practice of Medicine, Fifth Edition, p. 1118. Google Scholar(6) ELY : Inflammation of Bones and Joints, Vol. I, p. 110. 1923. Google Scholar(7) MUTCH N: Arthritis and Infection of the Digestive Tract, M. J. & Rec. (Supp) 121:625. 1925. KEEN'S SURGERY: p. 301. TURNBULL, J. A.: Food Allergens in connection with arthritis. Boston, M. & J. Surg. J. 191:438. 1924. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Excelsior Springs, Missouri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1928Volume 1, Issue 7Page: 513-516KeywordsArthritisEtiologyKnees Issue Published: 1 January 1928 PDF downloadLoading ...
Aspirin with Bypass Surgery — From Taboo to New Standard of Care
Authors: Eric J. Topol
Journal: New England Journal of Medicine (2002)

Until a few years ago, we did not understand the pivotal role of platelets in orchestrating the process of inflammation. The discovery in 1998 that CD40 ligand is shed from activated platelets to directly initiate inflammation of the vessel wall1 was a seminal event. It led to a new understanding of the function of platelets, clarifying that, in addition to their well-established function of governance of homeostasis, platelets also have the integrated role of principal modulator of inflammation. Not only do platelets account for 90 percent of the CD40 ligand in the body, but they contain and produce key inflammatory . . .
Botulinum A Toxin and Detrusor Sphincter Dyssynergia: A Double-Blind Lidocaine-Controlled Study in 13 Patients with Spinal Cord Disease
Authors: Marianne de Sèze, Hervé Petit, Philippe Gallien, Mathieu-Panchoa de Sèze, Pierre-Alain Joseph, Jean-Michel Mazaux, Michel Barat
Journal: European Urology (2002)
On the Mechanism of Cardiac Glycoside Action
Authors: LINDA STOWRING, WILLIAM J. BOWEN, PATRICK MATTINGLY, MANUEL MORALES
Journal: Circulation Research (1966)

A study has been made of the effect of ouabain and other cardiac glycosides on a faithful model of contraction, viz. the "superprecipitation" which occurs when ATP is added to a suspension of purified myosin B. Structural changes during superprecipitation were followed by a turbidity method, and rates of ATP utilization with a pH stat. At "optimal" concentrations (ca. 10 -9 M and 10 -3 M) these substances approximately double the structural and the ATP utilization rates of the myosin B system, but at no concentration do they affect the ATPase of myosin A. In the one case studied, cardioactivity of the substance appeared to parallel its effect in our test system.
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo
Authors: Petter S. Woll, Una Kjällquist, Onima Chowdhury, Helen Doolittle, David C. Wedge, Supat Thongjuea, Rikard Erlandsson, Mtakai Ngara, Kristina Anderson, Qiaolin Deng, Adam J. Mead, Laura Stenson, Alice Giustacchini, Sara Duarte, Eleni Giannoulatou, Stephen Taylor, Mohsen Karimi, Christian Scharenberg, Teresa Mortera-Blanco, Iain C. Macaulay, Sally-Ann Clark, Ingunn Dybedal, Dag Josefsen, Pierre Fenaux, Peter Hokland, Mette S. Holm, Mario Cazzola, Luca Malcovati, Sudhir Tauro, David Bowen, Jacqueline Boultwood, Andrea Pellagatti, John E. Pimanda, Ashwin Unnikrishnan, Paresh Vyas, Gudrun Göhring, Brigitte Schlegelberger, Magnus Tobiasson, Gunnar Kvalheim, Stefan N. Constantinescu, Claus Nerlov, Lars Nilsson, Peter J. Campbell, Rickard Sandberg, Elli Papaemmanuil, Eva Hellström-Lindberg, Sten Linnarsson, Sten Eirik W. Jacobsen
Journal: Cancer Cell (2014)
Vasculitis and Melphalan
Authors: Michael W. Skehan
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Of the many complications associated with cancer chemotherapy, vasculitis is not included. We report a case of apparent melphalan (Alkeran)-induced vasculitis. <h3>Report of a Case.—</h3> A 52-year-old woman came to the Oncology Department of the Geisinger Medical Center for evaluation of a malignant pleural effusion. A primary lesion was ultimately discovered at laparotomy as an adenosquamous carcinoma of the ovary. Three weeks after surgery, therapy was begun with melphalan, 1 mg/kg over four days per month. On the third day of her first cycle, painful discoloration of the left second toe developed. She denied trauma, prior complaints in the toe, or claudication. Other medications included bisacodyl (Dulcolax), yellow phenolphthalein (Ex-Lax), and levorphanol tartrate (Levo-Dromoran) when needed. The only known allergy was to penicillin. On examination, there was reticulated cyanosis of the digit, with a 2-cm extension onto the dorsum of the foot with slight involvement of the
The Disconnect between China's Public Health and Public Security Responses to Injection Drug Use, and the Consequences for Human Rights
Authors: Stephen Koester
Journal: PLoS Medicine (2008)

This Perspective discusses the following new study published in PLoS Medicine: Cohen JE Amon JJ (2008) Health and human rights concerns of drug users in detention in Guangxi Province China. Based on their review of Chinese government legislation and policy documents and using interviews with recently detained injection drug users and officials in Guangxi Province Elizabeth Cohen and Joseph Amon find evidence of antinarcotics policies and practices that may compromise the health and human rights of drug users.
Canadian doctors support new stance on dying with dignity as legislative changes loom
Authors: B. Kermode-Scott
Journal: BMJ (2014)

Delegates at the Canadian Medical Association’s (CMA) general council meeting have overwhelmingly backed moves to modify the association’s existing policy on physician assisted death.

At the meeting in Ottawa on 19 August, 91% of delegates voted to adopt an advisory resolution presented by the CMA’s board of directors that said it “supports the right of all physicians, within the bounds of existing legislation, to follow their conscience when deciding whether to provide medical aid in dying.”

The decision recognised likely impending changes to Canada’s legislation surrounding “dying in dignity.” Euthanasia and assisted suicide are currently illegal in Canada under its criminal code, but in June 2014 Quebec became the first Canadian province to adopt right to die legislation. When it comes into force, Quebec’s Bill 52 will …
Primary Sjögren's Syndrome and Other Autoimmune Diseases in Families
Authors: JOHN D. REVEILLE
Journal: Annals of Internal Medicine (1984)

The relationships of human leukocyte antigen (HLA) and heavy chain immunoglobulin (Gm) haplotypes to disease and autoantibody expression were examined in six large kindreds, each having one or more members with primary Sjögren's syndrome. Various other autoimmune diseases and autoantibodies occurred among the 117 relatives in these families. The HLA and Gm haplotypes did not necessarily segregate persons into those with Sjö7gren's syndrome, other autoimmune disorders, or serologic abnormalities, but HLA alleles DR3 and DR2 occurred in significant excess in relatives with Sjögren's syndrome, irrespective of HLA haplotype. Segregation analysis suggested a Mendelian dominant genetic defect common to the many autoimmune diseases and serologic reactions that was not linked to HLA or Gm. A significant effect of female sex was also documented. These studies suggest that Sjögren's syndrome results from the interaction of several HLA-linked and non-HLA-linked genes.
Rabeprazole Is Effective in Treating Laryngopharyngeal Reflux in a Randomized Placebo-Controlled Trial
Authors: Paul K.Y. Lam, Manwa L. Ng, Ting K. Cheung, Birgitta Y.H. Wong, Victoria P.Y. Tan, Daniel Y.T. Fong, William I. Wei, Benjamin C.Y. Wong
Journal: Clinical Gastroenterology and Hepatology (2010)
Social prognosis in patients with ulcerative colitis.
Authors: C Hendriksen, V Binder
Journal: BMJ (1980)

One hundred and twenty-two randomly selected patients with ulcerative colitis (28 of whom had undergone colectomy) were interviewed to obtain data on the quality of their family, emotional, social, and professional lives. They were compared with an age- and sex-matched group of patients with acute conditions from the same area. The two groups were similar in marital status, the frequency of severe family or sexual problems, leisure activities, physical and earning capacity, the incidence of mental disorders before the interview, and intake of alcohol and psychopharmacological drugs. A higher proportion of the patients with colitis had had a higher education and belonged to higher socioeconomic groups than the controls, and this difference had been present at the time of diagnosis. These results show that patients with ulcerative colitis seem to adapt themselves well to their condition and suffer few social or professional disabilities.
Kidney-to-Liver Ratio A Simple Scintigraphic Parameter for Routine Individual Renal Function Assessment in Children
Authors: BABINGTON C. K. YUNG, SAMUEL SOSTRE
Journal: Clinical Nuclear Medicine (1994)

DTPA renography is commonly used for measuring relative renal function. However, in patients with bilateral renal disease or solitary kidneys, split function studies are of no value. Available techniques to quantify individual renal function are either time consuming or inaccurate. The authors validate the kidney-to-liver ratio at 3 minutes (K3/L3) as an index of renal function, showing excellent correlation with GFR. Normal K3/L3 ranges were then computed in 113 pediatric kidneys (age 2 days to 16 years) and 24 adults. Indicative of renal maturation, the K3/L3 rapidly rose from a value of 1.32 at birth to 2.02 at 6 months. Subsequently, it increased slowly to reach a peak of 2.34 at age 2, followed by gradual decline to adult values after age 5. This decrease is due likely to continued growth of the hepatic blood pool after renal maturation. GFR followed the same maturation pattern to reach a plateau around 2 years of age. K3/L3 reflects individual kidney function, and it requires no blood sampling or urine collection. By establishing normal values at different stages of maturity, this method provides identification and quantification of renal dysfunction in infants, children, and adults.
Fluoxetine for Treatment of Anorexia Nervosa—Reply
Authors: B. Timothy Walsh, Christina A. Roberto, Allan S. Kaplan, Wendi Rockert
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CARDIAC FAILURE AND RHYTHM OF THE HEART
Authors: Phillip Hallock
Journal: JAMA (1942)

<h3>To the Editor:—</h3> A brief note appearing in Tonics and Sedatives inThe Journal, May 30, was entitled "Get Together Boys" (contributed by a "Colleague"). The contradiction which this title called attention to does have a serious as well as a more humorous aspect, and it is because of the former that we wish to publish this explanatory note. The contradiction referred to occurred in volume 4 of the<i>New International Clinics</i>(1941). On page 4 Keefer states that "the vast majority of patients with heart failure regardless of its cause show a normal cardiac rhythm." On page 165 of the same volume, Hallock, Larson and Watson state that "it is generally agreed that the majority of cases of cardiac failure are accompanied by auricular fibrillation." This statement was based on the statistics of Mackenzie (1913) and Lewis (1937) with respect, however, to severe congestive heart failure. In writing this
CORRELATION BETWEEN CRANIAL COMPUTED TOMOGRAPHIC SCANS AT DIAGNOSIS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKAEMIA AND CENTRAL NERVOUS SYSTEM RELAPSE
Authors: Momcilo Jankovic, Carlo De Grandi, Roberto Colella, Alma Lippi, Vico Vecchi, Giuseppe Scotti, Federica Zanetto, Maria Teresa Di Tullio, Orietta Scattolin, Riccardo Riccardi
Journal: The Lancet (1988)
Longitudinal melanonychia and pseudo-Hutchinson sign associated with amlodipine
Authors: M.J. Sladden, N.J. Mortimer, J.E. Osborne
Journal: British Journal of Dermatology (2005)

Journal Article Longitudinal melanonychia and pseudo‐Hutchinson sign associated with amlodipine Get access M.J. Sladden, M.J. Sladden Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K. E‐mail: m.sladden@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar N.J. Mortimer, N.J. Mortimer Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K. E‐mail: m.sladden@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar J.E. Osborne J.E. Osborne Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K. E‐mail: m.sladden@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 1, 1 July 2005, Pages 219–220, https://doi.org/10.1111/j.1365-2133.2005.06668.x Published: 01 July 2005
Abstract 3680: Comparison of risk of advanced cervical lesions among women with first detection of atypical squamous cells, atypical glandular cells, and low-grade squamous intraepithelial lesions by Pap smear
Authors: Yun-Yuan Chen, San-Lin You, Shin-Lan Koong, Chi-An Chen, Chien-Jen Chen
Journal: Cancer Research (2011)

Abstract The study aimed to examine the incidence of invasive cervical cancer (ICC), cervical carcinoma in situ (CIS), and cytologic high-grade squamous intraepithelial lesions (HSIL) or more severe cytologic lesions among women detected their first atypical squamous cell undetermined of significance (ASC), atypical glandular cells (AGC), and low-grade squamous epithelial lesions (LSIL), and to estimate the associations between the subsequent follow-up attending and risks of developing cervical cancer. National cervical cancer screening program in Taiwan has been implemented since 1995, all screening records are mandatory to report, and a centralized screening database has been established as well. The first cytologic abnormalities, included 110,561 ASC cases, 8,339 AGC cases, and 45,671 LSIL cases, and cytologic HSIL or above lesions were identified from Taiwan cervical cancer screening registry. Women received Pap smear or biopsy in one year after their first cytologic abnormalities were considered have attended subsequent follow-up. Cervical cancers were ascertained from national cancer registry in Taiwan until Dec, 31st, 2007. Hazard ratios were estimated by Cox's proportional hazards model, and cumulative incidences were estimated by Nelson-Aalen method. There was at least 14% reduction of CIS and 23% reduction of ICC if women attended screening two years before their first abnormalities, and at least 32% reduction of CIS and 58% reduction of ICC if they attended screening within two years. Follow-up attending for the first abnormality significantly reduced 13% to 53% of cytologic HSIL occurrence, 40% to 49% of CIS occurrence, and 52% to 71% of ICC occurrence. AGC is the most clinical significant lesion compared with ASC and LSIL, and is suggestive to include in the positivity follow-up system. Compared to LSIL, ASC is less risky to develop cytologic HSIL, similar risk to develop CIS, and possesses more risk to develop ICC. Subsequent follow-up attendance for their first abnormality and previous negative smear detection were inversely associated with cervical cancer occurrence. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3680. doi:10.1158/1538-7445.AM2011-3680
ABNORMAL ANKLE-BRACHIAL INDEX PREDICTS AN ABNORMAL STRESS TEST BUT DOES NOT CORRELATE WITH ISCHEMIC BURDEN
Authors: Mehdi H. Shishehbor, Rayan Yousefzai, Lillian H. Batizy, Manuel D. Cerqueira, Wael A. Jaber, Richard Grimm, Heather L. Gornik, Esther S. Kim, Penny L. Houghtaling, Sridhar Venkatachalam, Bruce H. Gray, John R. Bartholomew, Eugene H. Blackstone
Journal: Journal of the American College of Cardiology (2011)
VARIATION IN PERIOPERATIVE MANAGEMENT OF NORWOOD SURGERY IN THE PEDIATRIC HEART NETWORK'S SINGLE VENTRICLE RECONSTRUCTION TRIAL
Authors: Richard G. Ohye, Gail D. Pearson, Minmin Lu, Jonathan Kaltman, Christopher Caldarone, Christopher Derby, Carolyn Dunbar-Masterson, J. William Gaynor, Jeffrey P. Jacobs, A.K. Kaza, Sara K. Pasquali, John F. Rhodes, Mark Scheurer, Eric Silver, Lynn A. Sleeper, Sarah Tabbutt, James S. Tweddell, Karen Uzark, Winfield Wells, Jane Newburger
Journal: Journal of the American College of Cardiology (2011)
Etanercept for severe psoriasis and psoriatic arthritis: observations on combination therapy: reply from author
Authors: N.J. Lowe
Journal: British Journal of Dermatology (2002)

Sir, I thank doctors Davison, Bunker and Basarab for their comments on our recent publication about combination therapy with etanercept in psoriasis.1 I share similar concerns to theirs regarding the safety of tumour necrosis factor (TNF) blocking drugs in psoriasis. We did discuss long‐term safety concerns in the concise communication. One of the questions that needs resolving on longer‐term etanercept therapy is the potential risk of malignancy. The paper by Smith and Skelton2 raises the definite need for routine skin cancer examination as the risk of skin malignancy may be greater with psoriasis than rheumatoid arthritis because of frequent past use of phototherapy. This paper had not been published at the time of our submission. Other potential risks with TNF blocking agents include reactivation of tuberculosis, herpes zoster and demyelinating disease. The two currently available TNF blocking drugs etanercept and infliximab interact at different receptor binding sites, via different cell‐mediated events, and have different routes and frequency of delivery. It remains to be seen if there is a different risk of malignancy between these two drugs.
Inducible ventricular arrhythmias in a naturally occurring model of cardiomyopathy
Authors: A. DUNNIGAN, G. R NOREN, S. EINZIG, D. G BENDITT, N. A STALEY, D W. BENSON
Journal: Cardiovascular Research (1984)

This study examined inducibility of ventricular tachyarrhythmias in turkeys with and without naturally occurring dilated cardiomyopathy. Using a transvenously positioned electrode catheter, 32 cardiomyopathy and 12 control unsedated turkeys aged 2 to 4 months were studied by right ventricular endocardial extrastimulus testing at basic pacing cycle lengths of 200 and 170 ms with both 1 and 2 extrastimuli and burst pacing at progressively shorter cycle lengths (200 to 100 ms). Following study, a dilatation index (determined as the ratio of left ventricular endocardial and epicardial diameter at level of the apex-base midpoint) was utilized to assess the functional severity of cardiomyopathy. All control turkeys had a dilatation index less than 0.3. In cardiomyopathic turkeys, dilatation index was normal (less than 0.3) in 3/32, showed mild to moderate dilatation in 25/32 (0.3 to 0.6), and severe dilatation in 4/32 (greater than 0.6). Results showed no difference in right ventricular effective or functional refractory periods between control and cardiomyopathic turkeys. Control turkeys had no inducible ventricular tachyarrhythmias, but 16/32 cardiomyopathic turkeys (p less than 0.005) had inducible ventricular tachyarrhythmias, consisting most frequently of two beats of rapid ventricular tachycardia supervened by ventricular fibrillation. In the cardiomyopathic turkeys, inducible tachyarrhythmias occurred in 1/3 with normal dilatation index, in 11/25 with mild to moderate dilatation, and in 4/4 with severe dilatation. Thus, inducibility of ventricular tachyarrhythmias in cardiomyopathic turkeys is closely associated with increasing ventricular dilatation, but does not correlate with altered right ventricular refractoriness. This model may be suitable for studying the relationship between ventricular tachyarrhythmias and cardiomyopathy.
Clinical Effectiveness of Boron Neutron Capture Therapy for a Recurrent Malignant Peripheral Nerve Sheath Tumor in the Mediastinum
Authors: Masayoshi Inoue, Chun Man Lee, Koji Ono, Minoru Suzuki, Toshiteru Tokunaga, Yoshiki Sawa, Meinoshin Okumura
Journal: Journal of Thoracic Oncology (2010)