The Central Nervous System in Leukemia
Authors: JOHN P. PHAIR
Journal: Annals of Internal Medicine (1964)

Article1 November 1964The Central Nervous System in LeukemiaJOHN P. PHAIR, M.D., ROBERT E. ANDERSON, M.D., HIDEO NAMIKI, M.D.JOHN P. PHAIR, M.D.Search for more papers by this author, ROBERT E. ANDERSON, M.D.Search for more papers by this author, HIDEO NAMIKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-863 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis report describes the central nervous system lesions in 165 cases of leukemia autopsied at the Atomic Bomb Casualty Commission (ABCC). Primary emphasis is placed upon the pathogenesis of intracerebral hemorrhage (1-7). The present study strongly implicates a grossly elevated leukocyte count (> 50,000/mm3) in the genesis of such lesions. Thrombocytopenia, while of some significance, appears to be of secondary importance. Additional correlations are made between central nervous system pathology and age, type of leukemia, and antileukemic therapy.Two unique features characterize the group of persons studied. Some were exposed to varying amounts of ionizing radiation at the time of...References1. SCHWABWEISS RSS: The neurologic aspect of leukemia. Amer. J. Med. Sci. 189: 766, 1935. CrossrefGoogle Scholar2. MOORETHOMASSHAWFREIREICH ELBRE: The central nervous system in acute leukemia. Arch. Intern. Med. (Chicago) 105: 451, 1960. CrossrefMedlineGoogle Scholar3. GROCHSAYREHECK SNGPFJ: Cerebral hemorrhage in leukemia. Arch. Neurol. (Chicago) 2: 439, 1960. CrossrefMedlineGoogle Scholar4. LEIDLERRUSSELL FWO: The brain in leukemia: a clinicopathologic study of 20 cases with a review of the literature. Arch. Path. (Chicago) 40: 14, 1945. Google Scholar5. WELLSSILVER CERT: The neurologic manifestations of acute leukemia: a clinical study. Ann. Intern. Med. 46: 439, 1957. LinkGoogle Scholar6. 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National Academy of Sciences-National Research Council under a grant from the U. S. Atomic Energy Commission administered in cooperation with the Japanese National Institute of Health of the Ministry of Health and Welfare.)Requests for reprints should be addressed to Robert E. Anderson, M.D., Atomic Bomb Casualty Commission, Hijiyama Park, Hiroshima, Japan. 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