tbuckley/cabot-search huggingface dataset:
P142Gadd45 gamma regulates cardiomyocytes death and post-myocardial infarction left ventricular remodeling
Authors: A Lucas, J Mialet-Perez, F Lezoualc′h, A Parini, M Marber, P Sicard
Journal: Cardiovascular Research (2014)

Background: Postinfarction remodeling is accompanied and influenced by perturbations in oxidative stress status and MAPK signaling. The Growth arrest and DNA-damage-inducible 45 (Gadd45) proteins are small acidic proteins involved in modulation of MAPK activities. Despite its relationship with p38 MAPK and intense interest in the cancer field, little is known about the role of Gadd45 in the heart. Our aim is to explore the potential contribution of Gadd45 gamma (γ) isoform to the acute and late phase of heart failure after myocardial infarction (MI).
COMMON WHIPLASH INJURIES OF THE NECK
Authors: James R. Gay
Journal: JAMA (1953)

Interest in whiplash injury of the neck was aroused by the frequency in which this type of injury was encountered in neurosurgical practice and by the chronic nature of the symptoms that were observed after an accident that appeared to be of little consequence. In our experience, most of the accidents that involved a whiplash injury of the neck were caused by a collision in which one vehicle was rammed from behind by another vehicle. Since it has been estimated<sup>1</sup>that about 15% of all automobile accidents resulting in death, injury, or property damage are caused by a rear-end collision, it occurred to us that whiplash injuries might be encountered frequently in general medical practice. However, very little information on this subject has been published in textbooks or in the current medical literature. <h3>PERSONS STUDIED</h3> Fifty persons who suffered a whiplash injury of the neck between the years 1948
Immediate Partial Gastrectomy for Perforated Peptic Ulcer
Authors: B. C. Rowlands, P. A. King
Journal: BMJ (1955)

five elective partial gastrectomies were performed at the University Surgical Unit for severe recurrent symptoms following simple closure of a perforated peptic ulcer.The simple closure antedated the ultimate resection by periods varying from six months to three years.Impressed with the inconvenience to the patients of disabling symptoms in the intervening period and of the increased technical difficulties at the time of the second opera- tion, it was decided to treat certain selected cases of perforated peptic ulcers by immediate partial gastrectomy.
FUNCTIONAL IMAGING OF TUMOR PROTEOLYSIS
Authors: Bonnie F. Sloane, Mansoureh Sameni, Izabela Podgorski, Dora Cavallo-Medved, Kamiar Moin
Journal: The Annual Review of Pharmacology and Toxicology (2005)

▪ Abstract The roles of proteases in cancer are now known to be much broader than simply degradation of extracellular matrix during tumor invasion and metastasis. Furthermore, proteases from tumor-associated cells (e.g., fibroblasts, inflammatory cells, endothelial cells) as well as tumor cells are recognized to contribute to pathways critical to neoplastic progression. Although elevated expression (transcripts and proteins) of proteases, and in some cases protease inhibitors, has been documented in many tumors, techniques to assess functional roles for proteases require that we measure protease activity and inhibition of that activity rather than levels of proteases, activators, and inhibitors. Novel techniques for functional imaging of protease activity, both in vitro and in vivo, are being developed as are imaging probes that will allow us to determine protease activity and in some cases to discriminate among protease activities. These should be useful clinically as surrogate endpoints for therapies that alter protease activities.
Prevalence of the coexistence of left ventricular false tendons and premature ventricular complexes in apparently healthy subjects: A prospective study in the general population
Authors: Michihiro Suwa, Yuzo Hirota, Kiyotaka Kaku, Yutaka Yoneda, Akiko Nakayama, Keishiro Kawamura, Kazuhide Doi
Journal: Journal of the American College of Cardiology (1988)
Radionuclide Venography in Subclavian Vein Thrombosis Complicating Parenteral Nutrition
Authors: ALAN H. MAURER, FRANCIS C. AU, LEON S. MALMUD, R ROBERT HARWICK
Journal: Clinical Nuclear Medicine (1984)

Subclavian vein thrombosis and thrombophlebitis are common complications of subclavian vein catheterization for parenteral nutrition. We report two cases that demonstrate that radionuclide venography can be used to diagnose subclavian vein obstruction before classic clinical signs develop.
Management of Common Pulmonary Diseases
Authors: William S. Schwartz
Journal: JAMA (1962)

Summary Report of the 21st Research Conference on Pulmonary Diseases of the Veterans Administration and the Armed Forces THE 21ST RESEARCH CONFEBENCE on Pulmonary Diseases of the Veterans Administration and the Armed Forces met in St. Louis, Jan. 22-25, 1962. The change in the name of the conference from Chemotherapy of Tuberculosis, last year, reflects the increasing interest in nontuberculous pulmonary diseases. Fifty-two papers were presented, and these will be summarized along with pertinent comments which occurred during the discussion periods; however, the names of the individual authors will not be mentioned. Contributors included representatives from the cooperating Veterans Administration and Armed Forces hospitals, consultants, and guests. This is the tenth in a series of such reports. Pulmonary Tuberculosis <i>Steroid Therapy</i>—The first study, in which 8 Veterans Administration hospitals cooperated, was designed to determine the effect of steroid therapy on the incidence of favorable roentgenographic change, the disappearance of tubercle bacilli
Pneumothorax During Surgery
Authors: Irving E. Gilbert
Journal: JAMA (1967)

<h3>To the Editor:—</h3> In the ANESTHESIA PROBLEM OF THE MONTH (<b>198</b>:655, 1966), "Pneumothorax During Surgery," a description is given of a bilateral pneumothorax occurring as surgery was beginning. Obviously, from the protocol, no definitive surgery had been initiated when the pneumothorax occurred. This case was very splendidly handled; however, I wonder about the judgment displayed in going ahead with the surgery after the very major complication of bilateral pneumothorax had occurred. It seems to me that sounder judgment would have been to consider the tracheostomy as a first stage, to treat the pneumothorax, and then, returning at a later date, to perform the definitive surgery as the second stage of the operation. I should appreciate Dr. Hamilton's comments.
Acquired von willebrand disease: Correction of hemostatic defect by high‐dose intravenous immunoglobulins
Authors: A. Delmer, M. H. Horellou, J. M. Bréchot, J. Prudent, F. Potevin, C. Lecrubier, C. Girard‐Longhini, M. Samama, R. Zittoun
Journal: American Journal of Hematology (1992)

Abstract High‐dose intravenous immunoglobulins (ivIG) were used in a 57‐year‐old patient with acquired von Willebrand disease in order to correct a hemostatic defect before pneumonectomy for lung carcinoma. IvIG induced a rapid and complete correction of factor VIII (F VIII) and von Willebrand factor (vWF) and allowed surgery without additional factor coverage. F VIII and vWF returned to baseline values within 10 days after ivIG. © 1992 Wiley‐Liss, Inc.
Decrease in CD3−CD8 and Vγ9/Vδ2 TCR+ T cell count and low perforin expression is associated with an impairment of natural killer cell activity in hepatitis C virus (HCV) infection. The enhancing effects of interferonα 2B treatment
Authors: G. Pár, A. Pár, D. Rukavina, M. Horányi, J. Szekeres-Bartho, G. Hegedüs, M. Paál, Gy. Mózsik
Journal: Journal of Hepatology (2000)
Drug Metabolism and Variability among Patients in Drug Response
Authors: Grant R. Wilkinson
Journal: New England Journal of Medicine (2005)

Differences in drug responsiveness are common, often leading to challenges in optimizing the dosage regimen for a particular patient. Recent advances provide a rational framework for understanding many interpatient differences in drug disposition and their clinical consequences. This article focuses on the cytochrome P-450 enzymes, a superfamily of microsomal drug-metabolizing enzymes that play an important role in oxidative drug metabolism.
SEPARATION OF HUMAN LYMPHOID CELLS INTO G1, S, AND G2 CELL CYCLE POPULATIONS BY USE OF A VELOCITY SEDIMENTATION TECHNIQUE
Authors: Lloyd K. Everson, Donald N. Buell, G. Nicholas Rogentine
Journal: The Journal of Experimental Medicine (1973)

Human lymphoid tissue culture cells can be separated according to cell size and corresponding cell cycle phase with a velocity sedimentation centrifugation method employing a continuous 5–20% wt/wt Ficoll gradient. A 7-fold increase in streaming limit was achieved by placing a buffer zone of isosmolar 5% Ficoll on top of the gradient before application of the cell load. The various pooled populations of cells from upper, middle, and lower areas of the gradient were characterized using autoradiographic, TCA-precipitable 3H]thymidine incorporation, and Fuelgen microspectrophotometric methods. The upper range of the gradient contains cells in the G1 cell cycle phase; the lower range, cells in the G2 phase; cells found in the middle of the gradient belong largely to the S phase of the cell cycle. These gradient-separated cell pools contained relatively little contamination with cells from other phases of the cell cycle and, when explanted from the gradient into fresh growth media, showed growth patterns characteristic of synchronized cell populations. This system of cell separation provides a useful tool for investigating the relationship of the cell cycle to surface membrane and metabolic characteristics in human lymphoid cell culture systems.
A Basic Lesson Relearnt: The singing histopathologist
Authors: I. Neale
Journal: BMJ (1997)

David was not a frequent attender at surgery on his own behalf. With his marching gait and handlebar moustache, I would see him striding around the practice area dispensing Royal British Legion aid and support to my patients. One day, however, he came to tell me that he was dying. He demonstrated his jaundice with a wry smile and then proffered the diagnosis–cancer of the bile duct. “It runs in my family, my father died of it,” he said …
Intracellular pH and role of Na+/H+ exchange during ischaemia and reperfusion of normal and diabetic rat hearts
Authors: N. Khandoudi, M. Bernard, P. Cozzone, D. Feuvray
Journal: Cardiovascular Research (1990)

Journal Article Intracellular pH and role of Na+/H+ exchange during ischaemia and reperfusion of normal and diabetic rat hearts Get access Nassirah Khandoudi, Nassirah Khandoudi Correspondence to: Professor Feuvray Search for other works by this author on: Oxford Academic PubMed Google Scholar Monique Bernard, Monique Bernard Search for other works by this author on: Oxford Academic PubMed Google Scholar Patrick Cozzone, Patrick Cozzone Search for other works by this author on: Oxford Academic PubMed Google Scholar Danielle Feuvray Danielle Feuvray Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 11, November 1990, Pages 873–878, https://doi.org/10.1093/cvr/24.11.873 Published: 01 November 1990 Article history Received: 03 January 1990 Accepted: 18 May 1990 Published: 01 November 1990
Depressive Symptoms and Diabetes
Authors: David E. Kemp
Journal: JAMA (2008)

To the Editor: In their longitudinal cohort study, Dr Golden and colleagues 1 reported an inverse association between impaired fasting glucose and depressive symptoms; a positive association was identified between treated type 2 diabetes and the development of depressive symptoms.A complementary analysis showed a significantly higher incidence of type 2 diabetes among participants with elevated depressive symptoms.However, the authors did not report whether there was an association between baseline depressive symptoms and the incidence of impaired fasting glucose.This is important because early identification of prediabetes and sub-sequent intervention with lifestyle modifications or pharmacotherapy (eg, metformin) may reduce the onset of type 2 diabetes. 2
Induction of antigen spread after sipuleucel-T treatment and its association with improved clinical outcome
Authors: Debraj GuhaThakurta, Li-Qun Fan, Tuyen Vu, Nadeem A Sheikh, James B Trager
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts An effective cancer immunotherapy that triggers immune-mediated lysis of tumor cells, may lead to the priming of T or B lymphocytes against tumor antigens distinct from the initial target/s of the therapy. This is referred to as antigen or epitope spread. Evidence of antigen
His Electrogram Alternans Reveal Dual Atrioventricular Nodal Pathway Conduction During Atrial Fibrillation
Authors: Youhua Zhang, Saroja Bharati, Kent A. Mowrey, Todor N. Mazgalev
Journal: Circulation (2003)

Traditional tools to study dual-pathway atrioventricular nodal (AVN) electrophysiology are not applicable in subjects with permanent atrial fibrillation (AF). The presence of fast-pathway (FP) and slow-pathway (SP) wavefronts and their possible modification remain uncertain in this condition. We demonstrated previously that His electrogram (HE) alternans can determine whether the FP or the SP reaches the His bundle on a beat-by-beat basis. We have now applied this novel index to monitor dual-pathway conduction and the effects of SP modification during AF.In 12 rabbit AVN preparations, HE alternans were confirmed during a standard A(1)A(2) pacing protocol. During AF, in 9 of the 12 hearts, HE alternans indicated the presence of dual pathways. Successful SP modification guided by the HE alternans eliminated the SP, resulting in a predominantly FP conduction during AF in all hearts. This increased the average His-His interval (204+/-14 versus 276+/-51 ms, P<0.001). Morphological studies revealed that SP modification damaged only the posterior extension of the AVN.We have demonstrated for the first time in rabbits that HE alternans permit "visualization" of dual-pathway electrophysiology and confirmed the presence of both FP and SP wavefronts during AF. This novel index has been used in a selective SP ablation that resulted in a significant slowing of the ventricular rate. HE alternans provide a new insight into the mechanisms of AVN conduction and could guide AVN modification for ventricular rate control in AF clinically.
Abstract 3162: Assessing the therapeutic and diagnostic potential of human thymidine kinase 1 in leukemia
Authors: Dagoberto Estevez, Robert A. Whitehurst, Daniel W. Sharp, Richard A. Robison, Kim L. O'Neill
Journal: Cancer Research (2011)

Abstract Thymidine Kinase 1 (TK1), a salvage pathway enzyme responsible for recycling thymine in cells for use in DNA replication and repair, is normally tightly regulated by the cell cycle; however research studies have shown that it is over-expressed and unregulated in cancer cells. Studies linking TK1 localization to the plasma membrane of lymphoma cells have suggested that this enzyme could also be used as a molecular target for cancer diagnosis and therapy. Previous research in our laboratory showed that TK1 located on the plasma membrane of different cancer cell lines had high enzymatic activity. This study was performed to support the eventual possibility of targeting TK1 for cancer diagnosis and immunotherapy in leukemias expressing high levels of TK1 on their plasma membrane. TK1 levels on plasma membrane were analyzed using a BD FACSCanto flow cytometry on lymphoblastoid cells derived from Burkitt's lymphoma (Raji cells), acute T cell leukemia (Jurkat cells), myeloblastic cells derived from promyelocytic leukemia (HL-60 cells), and normal lymphocytes from healthy individuals. Analysis was performed on unpermeabilized cells in exponential growth phase using both a mouse monoclonal anti-TK1 Ab and a rabbit polyclonal anti TK-1 Ab. Cells were incubated with human FcR blocking reagent to eliminate non-specific binding to Fc receptors. Permeabilized cells were excluded using propidium iodide staining. Using an IgG Isotype control we were able to select proper gating (0% binding). TK1 surface expression was compared to expression of sodium potassium ATPase, a common plasma membrane marker, and pan-leukocyte marker CD45. Results confirmed high levels of TK1 expression on cancer cell lines analyzed. Flow cytometry analysis showed that binding of the mouse monoclonal anti-TK1 Ab and rabbit polyclonal anti-TK1 Ab were 93.4% (SEM=1.05, N = 19) and 99.5 % (SEM=0.67, N=19) in Raji cells; 71.1% (SEM=3.41, N=19) and 89.4 % (SEM=2.74, N=19) in HL-60 cells; 63% (SEM=1.23, N=26) and 88.6% (SEM=1.81, N=27) in Jurkat cells. Lymphoblastoid cells showed significantly higher TK1 expression when compared to that of lymphocytes obtained from healthy individuals 9.9% (SEM=2.39, N=7) and 14.9% (SEM=2.43, N=3). When induced with pokeweed mitogen there was no increase in TK1 expression on the plasma membrane of normal dividing lymphocytes 7.9% (SEM=0.54, N=3) and 10.63% (SEM=2.89, N=3). Fluorescence microscopy observations provided more evidence of TK1 association with the plasma membrane of cancer cells. These results suggest that membrane-bound TK1 has potential for both diagnosis and immunotherapy in human leukemia. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3162. doi:10.1158/1538-7445.AM2011-3162
Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy
Authors: Sean M. Bagshaw, Stephen Lapinsky, Sandra Dial, Yaseen Arabi, Peter Dodek, Gordon Wood, Paul Ellis, Jorge Guzman, John Marshall, Joseph E. Parrillo, Yoanna Skrobik, Anand Kumar
Journal: Intensive Care Medicine (2008)
Small Renal Mass
Authors: Inderbir S. Gill, Monish Aron, Debra A. Gervais, Michael A.S. Jewett
Journal: New England Journal of Medicine (2010)

A 65-year-old man with a history of well-controlled hypertension presents for a follow-up visit after an incidental finding of a small mass in the right kidney on an abdominal computed tomographic scan (ordered to evaluate lower-quadrant pain, which has since resolved). The mass is 3.2 cm, anterior, heterogeneous, and solid, and is in the right renal hilum near the main renal artery, vein, and ureter; the left kidney appears normal. The patient feels well, his physical examination is unremarkable. His serum creatinine level is 1.2 mg per deciliter. How should this patient be further evaluated and treated?
Memory CD4+CCR5+ T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1
Authors: Madeleine J. Bunders, Chris M. van der Loos, Paul L. Klarenbeek, John L. van Hamme, Kees Boer, Jim C. H. Wilde, Niek de Vries, Rene A. W. van Lier, Neeltje Kootstra, Steven T. Pals, Taco W. Kuijpers
Journal: Blood (2012)
Early diagnosis and successful treatment of small-intestinal carcinoid tumor: useful combination of capsule endoscopy and double-balloon endoscopy
Authors: H. Yamagishi, H. Fukui, K. Shirakawa, T. Oinuma, H. Hiraishi, A. Terano, T. Fujimori, T. Nakamura
Journal: Endoscopy (2007)

A 38-year-old man with bloody stools underwent esophagogastroduodenoscopy and colonoscopy. However, no bleeding point was detected and therefore, bleeding in the small intestine was considered likely.
Acetazolamide
Authors: Jean-Paul Richalet, Maria Rivera, Patrick Bouchet, Eduardo Chirinos, Igor Onnen, Olivier Petitjean, Annick Bienvenu, Francçoise Lasne, Stéphane Moutereau, Fabiola León-Velarde
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Chronic mountain sickness or Monge's disease is characterized by an excessive polycythemia in high-altitude dwellers, with a prevalence of 5 to 18% above 3,200 m. To date, no pharmacologic treatment is available.We evaluated the efficacy of acetazolamide in the treatment of chronic mountain sickness and the importance of nocturnal hypoxemia in its pathophysiology.A double-blind placebo-controlled study was performed in three groups of patients from Cerro de Pasco, Peru (4,300 m), treated orally for 3 weeks with placebo (n = 10), 250 mg of acetazolamide (n = 10), or 500 mg of acetazolamide (n = 10), daily.Acetazolamide decreased hematocrit by 7.1% (p < 0.001) and 6.7% (p < 0.001), serum erythropoietin by 67% (p < 0.01) and 50% (p < 0.001), and serum soluble transferrin receptors by 11.1% (p < 0.05) and 3.4% (p < 0.001), and increased serum ferritin by 540% (p < 0.001) and 134% (p < 0.001), for groups treated with 250 and 500 mg of acetazolamide, respectively. Acetazolamide (250 mg) increased nocturnal arterial O(2) saturation by 5% (p < 0.01) and decreased mean nocturnal heart rate by 11% (p < 0.05) and the number of apnea-hypopnea episodes during sleep by 74% (p < 0.05). The decrease in erythropoietin was attributed mainly to the acetazolamide-induced increase in ventilation and arterial O(2) saturation.Acetazolamide, the first efficient pharmacologic treatment of chronic mountain sickness without adverse effects, reduces hypoventilation, which may be accentuated during sleep, and blunts erythropoiesis. Its low cost may allow wide development with a considerable positive impact on public health in high-altitude regions.
Candida Blastospores and Pseudohyphae in Blood Smears
Authors: Joseph Portnoy, Paul L. Wolf, Margaret Webb, Jack S. Remington
Journal: New England Journal of Medicine (1971)

THE most common fungi responsible for systemic infection in the compromised host are species of candida.1 2 3 4 5 In a recent review of a total experience with deep fungal infections in an inpatient population at Stanford, 58 per cent were reported to be caused by candida species, and all occurred in patients with serious underlying disorders.5 Despite an awareness of the great frequency of systemic candida infections in this type of patient, the diagnosis was made before autopsy in only about 50 per cent of the cases.Our observation of pseudohyphae and blastospores in smears of peripheral venous blood and central-venous-pressure (CVP) . . .
Myocardial thallium-201 uptake and long-term functional recovery after myocardial infarction with reperfusion therapy
Authors: Takao Mori, Katsumi Minamiji, Takatoshi Hayashi, Tooru Yamasaki, Akira Takarada, Shigeki Itoh, Hiroyuki Kurogane, Yutaka Yoshida
Journal: Journal of the American College of Cardiology (1990)