tbuckley/cabot-search huggingface dataset:
Increased wheezing risk with diesel exposure among children of younger mothers
Authors: Paloma I. Beamer, Nathan Lothrop, Debra A. Stern, Dean Billheimer, Anne L. Wright, Fernando D. Martinez
Journal: European Respiratory Journal (2015)

Lower respiratory tract illnesses (LRIs) are the largest cause of mortality among young children worldwide [1], and are associated with altered lung function, immune system development and respiratory disease in adulthood [2, 3]. Several studies have demonstrated associations between wheezing LRIs in early life and exposure to diesel traffic related air pollutants (D-TRAP) [1, 4, 5]. We, along with others, have previously demonstrated that younger maternal age at birth is also a risk factor for wheezing LRIs in the first year of life [6, 7]. Why children of younger mothers are more susceptible is unknown, but both altered responses to environmental challenges in their offspring due to maternal immaturity [6] and increased socioeconomic and environmental risks have been proposed as causes [8]. Association of wheeze with diesel pollution exposure is stronger in children of younger mothers <http://ow.ly/KMHTy>
Correctional Health Care Systems and Collaboration With Academic Medicine
Authors: Newton E. Kendig
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ventricular Tachycardia Treated with External Electric Countershock
Authors: Malcolm N. Blumenthal, David A. Berman, Carl S. Alexander
Journal: JAMA (1963)

ABSTRACT VENTRICULAR TACHYCARDIA is usually adequately controlled by various medications—procainamide hydrochloride and quinidine being the most effective. Recently external electric countershock has been recommended for patients failing to respond to drugs.1 This is a report of a man with a recent myocardial infarction who developed refractory ventricular tachycardia which was treated by external electric countershock.Report of a Case A 73-yr-old male had an acute posterior myocardial infarction in November, 1960. After an uncomplicated hospital course he was discharged on 5 mg of warfarin sodium daily. He remained well until May 25, 1962, at which time he suddenly developed dull, nonradiating lower anterior chest pain and upper abdominal pain of increasing severity. On May 28, 1962, because of pain and tachycardia, he was hospitalized. An electrocardiogram showed changes suggestive of ventricular tachycardia. The prothrombin content was 12% (38 sec with control of 14 sec); blood urea nitrogen was 21 mg%;
Second Bacteriological Study from a Maternity Hospital
Authors: F. Marsh
Journal: BMJ (1958)

MEDICAL JOURNAL_ least) from the animal killed into enough rats (six at least), otherwise light infections can easily be missed.In our opinion Ashcroft inoculated too little blood into too few rats; this may be the reason why he isolated so few strains from such a comparatively large sample of animals.Ex- periments of this kind must be designed with a broad sweep on a large scale and may have to be continued for a con- siderable time.
Indicator Measurement System.
Authors: Richard Koss, Deborah Nadzam, Jerod M. Loeb
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE OCCASIONAL CLINICAL RESEMBLANCE OF BLASTOMYCOSIS AND SYPHILIS TO SPOROTRICHOSIS
Authors: RICHARD L. SUTTON
Journal: JAMA (1913)

Prior to the publication of the classical studies of Schenck and Smith<sup>1</sup>in 1898, the cutaneous lesions of sporotrichosis were usually ascribed to syphilis, tuberculosis or coccic cellulitis, and even at this time the true nature of the condition often is not recognized. Blastomycetic dermatitis seldom simulates either sporotrichosis or syphilis, although its resemblance to tuberculosis verrucosis cutis is often so close as to require cultural differentiation. Of the following histories, that of sporotrichal infection is quite typical, and the one of syphilis fairly so; but the distribution and character of the lesions in the case of blastomycosis are somewhat unusual, and the entire clinical picture rather a puzzling one. <h3>Case 1.</h3> —E. W., housewife, colored, aged 46, was admitted to the skin clinic of the University of Kansas in November, 1911. The cutaneous history of the family was negative. The patient was a native of Alabama, and a
HEMATOPORPHYRIN TREATMENT OF SEVERE DEPRESSIONS
Authors: D. Louis Steinberg
Journal: American Journal of Psychiatry (1936)

1. Reports in the literature of the use of hematoporphyrin in the depressed psychoses were for the most part favorable. 2. There are by no means clear theories as to the physiological action of the drug. 3. Experiments with laboratory animals indicated a definite influence on the weight and an increased response to stimuli. 4. Laboratory studies had shown a tendency of the drug to elevate the blood count and to reduce the calcium level. 5. Fourteen patients in all were treated adequately with hematoporphyrin. 6. Two patients responded well, one of whom relapsed after a period of six weeks. The other continued to adjust on a low level. 7. Laboratory examinations failed to disclose any specific influence on the blood picture except a tendency to lowered cholesterol levels. 8. Our results do not warrant the use of this therapy in preference to any of the old armamentarium used in the treatment of depressed psychoses. 9. The use of this drug did not produce any deleterious toxic reaction.
RECTAL PARALDEHYDE AS A PRELIMINARY TO TONSILLECTOMY IN CHILDREN
Authors: M. Sourasky
Journal: BMJ (1930)

RECTAL PARALDEHYDE IN TONSILLECTOMY.[ITi.uOtmX993 two paintings a week, and, if this does not suffice, 1 per cent.mercuroclroine drops are given to tlhe patient to be instilled twice a day, but of late we hlave come to rely more and mnore on thle painting and to discard the drops wher-e possible, as they are cer-tainly mIessy " 'e use( by aniy patien-t who is not carefuil.We believe that every type of conjunctivitis is benefited by sct painting the.con-
Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy
Authors: George Haddad, Pavel Zhabyeyev, Maikel Farhan, Lin Fu Zhu, Zamaneh Kassiri, David C. Rayner, Bart Vanhaesebroeck, Gavin Y. Oudit, Allan G. Murray
Journal: Blood (2014)
Differential expression of the cell adhesion molecules ICAM-1, VCAM-1, and E-selectin in normal and posttransplantation myocardium. Cell adhesion molecule expression in human cardiac allografts.
Authors: J W Tanio, C B Basu, S M Albelda, H J Eisen
Journal: Circulation (1994)

BACKGROUND Cell adhesion molecules (CAMs) have been implicated in cardiac allograft rejection. However, previous studies have used qualitative analysis of immunohistochemical data and did not exclude patients with infection or malignancy. METHODS AND RESULTS We analyzed 40 endomyocardial biopsy specimens from 25 cardiac transplant patients and 8 specimens from patients undergoing cardiac surgery. Patients with evidence of infection or malignancy were excluded. Specimens were stained with monoclonal antibodies against ICAM-1, E-selectin, VCAM-1, and PECAM-1 (which labels all vessels). ICAM-1 expression was assessed by counting ICAM-1-positive vessels and dividing by the total number of vessels (measured by PECAM staining). Specimens were scored as positive or negative for VCAM-1 and E-selectin. We also determined whether serum-soluble ICAM-1 levels (sICAM) correlated with rejection by evaluating 145 serum specimens from 48 cardiac transplant patients and 8 specimens from patients undergoing diagnostic cardiac catheterization. ICAM-1 was present on 50% to 60% of vessels in normal and nonrejecting specimens. Specimens with histologically significant rejection (focal moderate, moderate, or severe) had an increased percentage of ICAM-1-positive vessels: focal moderate, 77%; moderate/severe, 92% (P &lt; .01). E-selectin expression did not differ between groups. VCAM-1 frequently was not present on rejecting specimens. No correlation was noted between sICAM levels and the presence or absence of rejection. CONCLUSIONS (1) ICAM-1 expression is strongly correlated with histologically significant cardiac allograft rejection. (2) The use of PECAM-1 staining as a vascular marker permits quantitative analysis of ICAM-1 expression. (3) VCAM-1 and E-selectin are not consistently increased during cardiac allograft rejection. (4) sICAM levels do not accurately reflect endomyocardial biopsy results.
DESCRIPTION OF A NEW ANOPHELES.
Authors: C. S. LUDLOW
Journal: JAMA (1902)

In carrying on the work on the mosquitoes of the Philippine Islands lately begun in connection with the study of tropical diseases by the Medical Department, U. S. A.,* some very interesting points have already developed. The<i>Stegomyia fasciata</i>, Fabricius, has been sent in from nearly every post where collections have been made, and five species of anopheles, one of which— a new species—is described below, were collected between Sept. 1 and Oct. 5, 1901.<i>Culex fatigans</i>Weid. is of course common and another mosquito which the English surgeons have in the last year proven a carrier of the embryo of<i>filaria nocturna, Panoplites (Mansonia) Africanus</i>, Theobald, was taken in large numbers in and near Manila. <h3>ANOPHELES PHILIPPINENSIS.—Ludlow.</h3><h3>Female:</h3> Head very dark brown, with white creamy (yellowish) scales scattered on top, and more thickly toward the front, long white tuft in front, a few yellowish scales on the sides,
Erectile Function and Naltrexone
Authors: JAY A. GOLDSTEIN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 November 1986Erectile Function and NaltrexoneJAY A. GOLDSTEIN, M.D.JAY A. GOLDSTEIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-5-799_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The male patient with erectile dysfunction who has had normal findings on urologic, endocrinologic, and hemodynamic evaluations is usually referred for sexual counseling with his partner or, possibly, for individual psychotherapy. When these approaches are not helpful, he may be classed as having "idiopathic" dysfunction and be left with the choices of papaverine injection, penile prosthesis insertion, or no further medical treatment. Treatment with naltrexone might provide another alternative.Seven middle-aged men had not been able to achieve a firm erection or ejaculation for a minimum of 2 years. After extensive workup, they were classed as having...Reference1. BERENDSENGOWER HA. Opiate-androgen interactions in drug-induced yawning and penile erections in the rat. Neuroendocrinology. 1986;42:185-90. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAY A. GOLDSTEIN, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Phase 2a Multicenter, Double‐Blind, Placebo‐Controlled, Crossover Trial to Investigate the Efficacy, Safety, and Toleration of CP‐866,087 (a High‐Affinity Mu‐Opioid Receptor Antagonist) in Premenopausal Women Diagnosed with Female Sexual Arousal Disorder (FSAD)Sexual inactivity results in reversible reduction of LH bioavailabilityPharmacological Aspects of Erectile DysfunctionMale Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and TreatmentNaltrexone-Induced Augmentation of Sexual Response in MenOral, Transdermal, and Transurethral Therapies for Erectile DysfunctionOral treatments for erectile dysfunctionNeurotransmetteurs cérébraux et contrôle du comportement sexuel masculinPharmacology of erection: Agents which initiate and terminate erectionPractical management of erectile dysfunctionNew Treatments for Erectile ImpotencePharmacological Enhancement of Human Sexual BehaviorFacteurs psychologiques et conjugaux de l'impuissance: Toujours d'actualiteNeuroendocrine control of male reproductive function. The opioid system as a model of control at multiple sitesEndorphins in male impotence: Evidence for naltrexone stimulation of erectile activity in patient therapyAssessment of erectogenic properties of apomorphine and yohimbine in man. 1 November 1986Volume 105, Issue 5Page: 799-799KeywordsEjaculationErectile dysfunctionHemodynamics ePublished: 1 December 2008 Issue Published: 1 November 1986 PDF downloadLoading ...
Survey of skin disorders in the urban black population of South Africa*
Authors: M. DOGLIOTTI
Journal: British Journal of Dermatology (1975)

Numerous and different methods of survey have been suggested and developed in recent years, but none of them appears to be entirely satisfactory. Insufficient classification, inadequate follow-up, incongruous rotation of investigators, notable variations in attendance, racial differences of the population submitted to statistical study, and other minor factors may account for possible errors and differences in evaluating the findings. We have conducted a survey, over a 3-year period, of the incidence of skin diseases affecting our urban black population, living in the township of Soweto (800,000 inhabitants) and attending our dermatological service at Baragwanath Hospital. Although this population is made up of a dozen different ethnic groups, they are fully urbanized and live under similar conditions and according to similar customs. We believe that the statistical data derived from these patients represent a significant expression of a uniform community.
Commentaries on the Cardiovascular Controversy by A A M Wilde
Authors: A A M Wilde
Journal: Cardiovascular Research (1994)

Journal Article Commentaries on the Cardiovascular Controversy by A A M Wilde Get access A A M Wilde A A M Wilde Department of Cardiology and Experimental Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 6, June 1994, Pages 928–929, https://doi.org/10.1093/cvr/28.6.928 Published: 01 June 1994
Serial Cardiac Catheterizations and Exercise Hemodynamics after Correction of Tetralogy of Fallot
Authors: J. DAVID BRISTOW, FRANK E. KLOSTER, MARTIN H. LEES, VICTOR D. MENASHE, HERBERT E. GRISWOLD, ALBERT STARR
Journal: Circulation (1970)

Eleven patients had right heart catheterization an average of 13 mo after total correction of tetralogy of Fallot, and the procedures were then repeated an average of 7 years postoperatively. In the intervening time there was generally no important change in the pressure gradient between the right ventricle and pulmonary artery or in right ventricular systolic pressure. Mean right atrial pressure tended to fall with time. Arteriovenous oxygen difference at rest was lower at the second study, and the resting cardiac output was generally normal. One patient with a persistent ventricular septal defect had progressive hemodynamic deterioration between the two studies. Exercise performance up to 10 years postoperatively was also assessed. The relationship between oxygen consumption and cardiac output was usually normal, but exercise magnified the right heart's filling pressure abnormalities. In the absence of an easily demonstrable ventricular septal defect, right heart hemodynamics were either stable or improved up to 10 years postoperatively. The exercise response of cardiac output was usually normal at moderate work loads.
Building a rational foundation for neural transplantation
Authors: Hasker P. Davis, Bruce T. Volpe
Journal: Behavioral and Brain Sciences (1995)

Abstract The neural transplantation research described by Sinden and colleagues provides part of the rationale for the clinical application of neural transplantation. The authors are asked to clarify their view of the role of the cholinergic system in cognition, to address extrahippocampal damage caused by transient forebrain ischemia, and to consider the effects of delayed neural degeneration in their structure-function analysis.
Wilms' Tumor 1 and Signal Transducers and Activators of Transcription 3 Synergistically Promote Cell Proliferation: A Possible Mechanism in Sporadic Wilms' Tumor
Authors: Yu Rong, Long Cheng, Hongxiu Ning, Jizhen Zou, Yuanjiang Zhang, Fang Xu, Li Liu, Zhijie Chang, Xin-Yuan Fu
Journal: Cancer Research (2006)

Abstract Transcription factor Wilms' tumor 1 (WT1) was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells, suggesting a potential oncogenic function of WT1. It is important to understand molecular mechanisms underlying these dual functions of WT1 in tumorigenesis. In the current study, we report a synergistic role for signal transducers and activators of transcription 3 (STAT3) and WT1 in tumor development, including Wilms' tumor. STAT3 interacts with WT1 through its conserved domains both in vitro and in vivo. When STAT3 is activated, expression of WT1 enhances STAT3 transcriptional activity. Overexpression of WT1 and STAT3CA in NIH 3T3 increases the expression level of STAT3 target genes, including cyclin D1 and Bcl-xL, which results in an advantage of cell proliferation. Our results suggest that in the presence of activated STAT3, WT1 promotes cell proliferation instead of suppressing cell proliferation. Strikingly, STAT3 translocates to the nucleus and interacts with WT1 in a variety of primary Wilms' tumor cells, raising the hypothesis that WT1 and activated STAT3 in Wilms' tumor accelerate tumorigenesis. (Cancer Res 2006; 66(16): 8049-57)
Abstract 5594: ALK-driven lung cancer: Potential therapeutic strategies for treatment and prevention of drug resistance
Authors: Amanda B. Pilling, Anh T. Le, Aik-Choon Tan, Jihye Kim, Katherine R. Singleton, Lynn E. Heasley, Barbara Helfrich, James DeGregori, Robert C. Doebele
Journal: Cancer Research (2012)

Abstract The identification of oncogenic molecular drivers in non-small cell lung cancer (NSCLC) has allowed biologically targeted therapies to improve clinical outcomes in the treatment of NSCLC. ALK gene rearrangements are observed in a sub-set of NSCLC patients who demonstrate high response rates to treatment with the oral kinase inhibitor, crizotinib. Unfortunately, disease progression is inevitable, either through intrinsic or acquired resistance. A recently completed series of crizotinib-resistant, ALK+ NSCLC patients by our group demonstrates two broad categories of resistance: (1) continued reliance on ALK signaling (via secondary mutations in the ALK kinase domain or ALK gene fusion copy number gain) or (2) loss of reliance on ALK signaling (e.g. via reliance on alternate oncogene signaling). Here we investigate potential therapeutic strategies when ALK signaling is retained. In an effort to minimize drug resistance to crizotinib in ALK+ NSCLC, we performed a genome-wide shRNA synthetic lethal screen to identify genes whose depletion synergizes with crizotinib in ALK+ NSCLC lines. We identified several genes involved in nucleotide synthesis and DNA metabolism, including dihydrofolate reductase (DHFR) and the trifunctional enzyme encoded by GART, which are substrates for inhibition with pemetrexed. Indeed, ALK+ NSCLC cell lines show increased sensitivity to pemetrexed in vitro. Identification of this cellular process as critical for ALK+ NSCLC is also consistent with clinical data demonstrating that patients with ALK+ NSCLC exhibit an increased clinical benefit on pemetrexed compared to other molecular subgroups of NSCLC. We also identified genes involved in chaperone function in our synthetic lethal screen. As such, we investigated whether proper folding and prevention of degradation was essential for continued reliance on ALK signaling. Both non-mutated EML4-ALK wild-type and EML4-ALK containing kinase domain mutations (including a novel mutation, G1269A) are sensitive to HSP inhibition with 17AAG. By identifying critical cellular processes in ALK+ lung cancer and employing therapies that target these pathways, improved treatment strategies can be derived to treat and prevent resistance in this molecular subtype of NSCLC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5594. doi:1538-7445.AM2012-5594
The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study
Authors: Bruno Girolami, Paolo Prandoni, Piero M. Stefani, Cinzia Tanduo, Paola Sabbion, Petra Eichler, Roberto Ramon, Giovannella Baggio, Fabrizio Fabris, Antonio Girolami
Journal: Blood (2003)
Chemokines of the α, β-subclass inhibit human basophils' responsiveness to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1
Authors: Piotr Kuna, Sesha R. Reddigari, Doreen Rucinskia, Thomas J. Schall, Allen P. Kaplan
Journal: Journal of Allergy and Clinical Immunology (1995)
SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK
Authors: Yutaka Okawa, Teru Hideshima, Paul Steed, Sonia Vallet, Steven Hall, Ken Huang, John Rice, Amy Barabasz, Brianna Foley, Hiroshi Ikeda, Noopur Raje, Tanyel Kiziltepe, Hiroshi Yasui, Sotaro Enatsu, Kenneth C. Anderson
Journal: Blood (2008)