tbuckley/cabot-search huggingface dataset:
General Health Checks in Adults
Authors: Roger M. Cass
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
CYSTIC OVARY IN THE PELVIS
Authors: E. L. Gowlland
Journal: BMJ (1911)

CYSTIC OVARY IN THE PELVIS.tOCT. 7, I9II, ptoms, wliiclh do not, lhowever, outlast tlle local irritation at the seat of contact, absence of pyrexia and mialaise, and the non-involvemenlt of the lymlphatic glanids.The abun- dant exaluples which could be adduced of remote vascular
Epicardial strains in embryonic chick ventricle at stages 16 through 24.
Authors: L A Taber, H Sun, E B Clark, B B Keller
Journal: Circulation Research (1994)

Embryonic cardiac development depends, in part, on the local biomechanical environment. Tracking the motions of microspheres attached to the embryonic chick ventricle, we computed two-dimensional epicardial strains at Hamburger-Hamilton stages 16, 18, 21, and 24 (2.5, 3.5, 4.0, and 4.5 days, respectively, of a 21-day incubation period). First, in a cross-sectional study, strains were measured in separate embryos at each stage (n &gt; or = 19 per stage). Then, in a longitudinal study, strains were measured serially on the same heart, with the eggs resealed and reincubated between successive stages (n &gt; or = 4 per stage). Although the heart undergoes major changes in mass, morphology, and loading during the studied stages, both studies showed that peak circumferential and longitudinal strains relative to end diastole were similar in magnitude (0.13 to 0.16) and did not change significantly across the stage range. The peak principal strains also showed no significant changes, with magnitudes of approximately 0.11 and 0.18. The shear strains were small, and their signs varied from one heart to another. These results suggest that wall strain is maintained within a relatively narrow range during primary cardiac morphogenesis.
Gifts from Physicians or Their Families
Authors: Fannie Hall Leslie
Journal: JAMA (1963)

<h3>To the Editor:</h3> —As a doctor's wife, I would prefer to pay a nominal fee and feel as free to call upon doctors as the ailing public does. As it is, I think twice or three times before consulting one, since I particularly dislike having taken up—for free—his time, should my ailment prove not to have justified it. But this apparently isn't in the cards, and so every now and then I find myself having sent a gift, of more or less value, as the only way in which to express my appreciation. And all too frequently, after as much as a month has gone by, I am still wondering, Did he or didn't he get it? Possibly the store delivered it to the wrong address, in which instance I should not pay their bill. Or maybe it got there all right but the receptionist just placed it on a
The essentiality of folate for the maintenance of deoxynucleotide precursor pools, DNA synthesis, and cell cycle progression in PHA-stimulated lymphocytes.
Authors: S J James, B J Miller, D R Cross, L J McGarrity, S M Morris
Journal: Environmental Health Perspectives (1993)

The fidelity and progression of DNA synthesis is critically dependent on the correct balance and availability of the deoxynucleoside triphosphate (dNTP) precursors for the polymerases involved in DNA replication and repair. Because folate-derived one-carbon groups are essential for the de novo synthesis of both purines and pyrimidines, the purpose of this study was to determine the effect of folate deprivation on deoxynucleotide pool levels and cell cycle progression. Primary cultures of phytohemagglutin (PHA)-stimulated splenocytes were used as the cellular model. T-cells and macrophages were purified from spleen cell suspensions obtained from F344 rats and recombined in culture. The cells were harvested after a 66-hr incubation with PHA and analyzed for nucleotide levels by reverse-phase HPLC with diode array detection. The proportion of cells in the different phases of the cell cycle was determined by bivariate flow cytometric measurement of bromodeoxyuridine (BrdU) incorporation and DNA content (propidium iodide staining). PHA-stimulated T-cells cultured in medium lacking folate and methionine manifested significant decreases in the deoxynucleotides dCTP, dTMP, dGTP, and dATP relative to cells cultured in complete medium. The reduction in dNTP pools was associated with a decrease in the corresponding ribonucleotide pools. Flow cytometric analysis revealed a 2-fold increase in S and G2/mitosis (G2/M) DNA content in PHA-stimulated cells cultured in the medium lacking folate and methionine, which suggests a delay in cell cycle progression. These alterations in DNA content were accompanied by a 5-fold decrease in BrdU incorporation relative to PHA-stimulated cells cultured in complete medium.(ABSTRACT TRUNCATED AT 250 WORDS)
Scientific Notation for Hemoglobin Munchausen
Authors: Joseph W. Weaver
Journal: JAMA (1974)

<h3>To the Editor.—</h3> At considerable expenditure of effort and money our laboratory has been able to complete the amino acid sequence in hemoglobin Munchausen discovered by Dr. John Lindenbaum.<sup>1</sup>We believe the standard scientific nomenclature<sup>2</sup>should be as follows: Hgb Munchausen α<sub>2</sub>β<sub>2</sub><sup>6glu→glu</sup>
Real-Life Use of Cetuximab in 1st-Line Treatment of Unresectable Metastatic Colorectal Cancer (MCRC) and Outcomes After Surgical Resection of Metastases: Updated Data from the Erebus Cohort
Authors: D. Smith, A. Sa-cunha, M. Rouyer, E. François, E. Mitry, A. Monnereau, J. Jové, E. Bignon, A. Balestra, P. Noize, N. Moore, A. Fourrier-Reglat
Journal: Annals of Oncology (2014)
STUDIES ON THE TRANSFER OF LYMPH NODE CELLS
Authors: T. N. Harris, Susanna Harris, Henry D. Beale, J. J. Smith
Journal: The Journal of Experimental Medicine (1954)

Cells of the popliteal lymph node were teased 3 days after the injection of Shigella paradysenteriae into the hind foot pads of rabbits. These cells were transferred to normal and x-irradiated recipients. It was noted that the serum titers of dysentery agglutinins in irradiated recipients were higher than in normal recipients. This was represented both in a higher peak: titer and a tendency to remain higher for a longer period than in normal animals. Recipients were x-irradiated within 1 hour after receiving cells of the lymph node prepared as indicated above. The serum titers of these recipients were markedly reduced in comparison with those of non-irradiated control animals. If the irradiation of the recipients followed the transfer of cells by a day, however, this difference was much smaller and in the case of a 2 day interval after the transfer of the lymph node cells the irradiation appeared to have no effect on the resulting serum titer.
Host immune response and variations in the virus genome: pathogenesis of liver damage caused by hepatitis B virus.
Authors: N V Naoumov, A L Eddleston
Journal: Gut (1994)

Host immune response and variations in the virus genome: pathogenesis of liver damage caused by hepatitis B virus Recent understanding of the mechanisms responsible for liver damage during an infection with hepatitis B virus has changed significantly with the application of molecular biological techniques, the formulation of new concepts for T cell recognition of viral antigens, and experience with orthotopic liver transplantation.Infection with hepatitis B virus (HBV) is associated with a wide spectrum of liver damage ranging from fulminant acute hepatitis to chronic HBV carriers with minimal hepatic changes or liver cirrhosis.This variation in liver damage was thought to be due to variations in the intensity of the host immune response to the virus.1 From a virological point of view two major subgroups of chronic HBV carriers were identified -HBeAg seropositive with active HBV replication, and patients seropositive for anti-HBe, characterised by the absence of virus replication.In the early phase of chronic infection HBV carriers are HBeAg seropositive with a high level of virus replication, but with minimal liver damage.2This immunotolerant phase is particularly long in cases with vertical transmission of HBV.With time there is a gradual loss of the immune tolerance to the virus, manifested by the onset of the active phase of chronic HBV infection.Histological examination of the liver shows chronic lobular, chronic persistent or chronic active hepatitis and an increase in serum amino- transferase activity.HBeAg and HBV-DNA are still present in the serum as markers of ongoing virus replication.The duration of this active phase has an important impact in determining whether a transformation of the normal liver architecture into a liver cirrhosis will follow.The immune pressure is concentrated on hepatocytes supporting HBV replication and eventually may eliminate these cells, leading to seroconversion to anti- HBe, undetectable HBV replication, and no hepatic inflammation.Recent knowledge has challenged this conventional concept of the immunopathogenesis of HBV related liver diseases.Immunology has made huge conceptual advances.It has been shown that T lymphocytes do not recognise large protein antigens but small peptide fragments of 8-16 amino acid residues, presented on July 22, 2023 by guest.
Electrohydraulic lithotripsy with peroral choledochoscopy.
Authors: J. W. Leung, S. S. Chung
Journal: BMJ (1989)

OBJECTIVE--To determine the efficacy of peroral electrohydraulic lithotripsy performed with an extra large duodenoscope (outside diameter 14.8 mm) and a choledochoscope with a diameter of 4.1 mm (Olympus "mother and baby" endoscope system) in the removal of very large stones from the common bile duct. DESIGN--Prospective study of patients with giant stones in the common bile duct that were resistant to extraction by conventional means. SETTING--Endoscopy unit at a university hospital. PATIENTS--Four women and one man aged 48-82 (mean 66.4 years) with a total of nine stones in their common bile ducts ranging from 2.2 to 3.6 cm in diameter. INTERVENTIONS--Peroral electrohydraulic lithotripsy was performed after intravenous sedation and under antibiotic cover. Two endoscopists took part in each procedure, coordination being achieved by means of a video monitor. The procedures were performed with a Lithotron EL-23 lithotripter and a 3 French lithotripsy probe inserted through the choledochoscope under direct vision. MAIN OUTCOME MEASURE--Complete clearance of the common bile duct confirmed by occlusion cholangiography. RESULTS--All nine stones (mean minimal diameter 2.6 cm; mean maximal diameter 3.1 cm) were successfully fragmented by electrohydraulic lithotripsy, allowing subsequent extraction with the aid of endoscopy and clearance of the common bile duct. A median of three (range two to five) sessions of endoscopic retrograde cholangiopancreatography were required to achieve complete clearance of the ducts. Patients stayed a median of eight days in hospital after lithotripsy (range eight to 14). There were no complications. CONCLUSION--Peroral electrohydraulic lithotripsy offers a safe and effective alternative for the management of patients with large stones in the common bile duct.
Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10
Authors: T C A Tolboom
Journal: Annals of the Rheumatic Diseases (2002)

Matrix metalloproteinases (MMPs) have a pivotal role in the destruction of cartilage in rheumatoid arthritis (RA), which is mediated by the fibroblast-like synoviocytes (FLS).To examine the in vitro invasiveness of synoviocytes obtained from inflamed joints of patients with arthritis in relation to the expression of MMP 1-14, 17, 19, cathepsin-K, the tissue inhibitors of matrix metalloproteinases TIMP-1 and TIMP-2 by FLS.FLS were derived from 56 patients (30 with RA, 17 with osteoarthritis (OA), and nine with avascular necrosis (AVN)). Invasive growth of FLS through an artificial matrix (Matrigel) was measured in a transwell system. The number of cells that migrated through the matrix were counted. Proliferation rate was determined by counting the FLS after seven days of culturing. Expression of MMPs, cathepsin-K and TIMPs was investigated with reverse transcriptase-polymerase chain reaction and related to the expression of a household gene, beta-actin.FLS from RA showed greater invasive growth than FLS from OA and AVN. The median number of cells that grew through the matrix membrane was 4788 for RA, significantly higher than the number for OA, 1875 (p<0.001) and for AVN, 1530 (p=0.014). The median rate of proliferation of RA FLS was 0.27 per day compared with OA 0.22 per day (p= 0.012) and AVN 0.25 per day, but there was no correlation between the rate of proliferation and invasive growth in vitro. FLS from RA and OA that expressed MMP-1, MMP-3, or MMP-10 were significantly more invasive (median number of invasive cells: 3835, 4248, 4990, respectively) than cells that did not express these MMPs (1605, p=0.03; 1970, p=0.004; 2360, p=0.012, respectively). There was also a significant relationship between the expression of MMP-1 and MMP-9 and the diagnosis RA (both p=0.013). The expression levels of mRNA for MMP-1 and MMP-2 correlated with the protein levels produced by the synoviocytes as measured by an enzyme linked immunosorbent assay (ELISA).FLS of RA invade more aggressively in a Matrigel matrix than OA and AVN FLS; this is not because of a higher rate of proliferation of RA FLS. The significant correlation between the expression of MMP-1, MMP-3, and MMP-10 and invasive growth in a Matrigel transwell system suggests that these MMPs play a part in the invasive growth of FLS obtained from patients with RA.
Synergy of understanding dermatologic disease and epidermal biology
Authors: John R. Stanley
Journal: Journal of Clinical Investigation (2012)

Dermatologic disease, although seldom life threatening, can be extremely disfiguring and interfere with the quality of life. In addition, as opposed to other organs, just the aging of skin and its adnexal structure the hair follicle can result in cosmetic concerns that affect most of us. The articles in this dermatology Review Series demonstrate recent progress in understanding the cell biology and molecular pathophysiology of the epidermis and hair follicles, which harbor keratinocyte and melanocyte stem cells. They reveal a dynamic relationship between research and clinical care: knowledge of dermatologic disease has facilitated the understanding of the biology of the epidermis and, in turn, progress in basic science has informed our understanding of disease. This type of synergy is a profound strength of clinical research of the type that the JCI is dedicated to publishing.
Pneumococcal pneumonia. A misleading diagnosis for audit studies
Authors: E. W. Saitz
Journal: JAMA (1978)

IN PREPARATION for a joint audit study, four community hospitals reviewed their statistics of patients discharged with a primary diagnosis of pneumonia during the past two calendar years. The total number of discharges was determined for each of the different International Classification of Diseases Adapted (ICDA) codes for pneumonia. In most persons, the cause of the pneumonia was not specified, but there were 48 cases of pneumococcal pneumonia from all hospitals during the two years. This seemed to be an unusually high number of reported cases for a group of small hospitals. Therefore, a special study of pneumococcal pneumonia was conducted along with a general study of pneumonia. Two screening criteria were used for the pneumococcal pneumonia study, which included (1) abnormal chest roentgenogram, ie, compatible with pneumonia anytime during admission, and (2) positive sputum culture for pneumococci. Of the 48 records coded as a primary discharge diagnosis of pneumococcal
PERIODIC HEALTH EXAMINATION
Authors: RICHARD E. WINTER
Journal: Annals of Internal Medicine (1965)

Letters and Comments1 April 1965PERIODIC HEALTH EXAMINATIONRICHARD E. WINTER, M.D.RICHARD E. WINTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-853 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In my opinion, the publication of "An Evaluation of the Periodic Health Examination" in the December issue of ANNALS OFINTERNALMEDICINEhas performed a minor disservice to the medical profession and a major disservice to the public. When this paper was presented at the New York Academy of Medicine, the majority of the audience was vociferous in their criticism of the paper, both on the grounds of scientific soundness and conclusions reached. Since physicians are capable of sophisticated judgments of medical presentations, the effect was minor. However, we all know that the lay public is not... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York City, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1965Volume 62, Issue 4Page: 853-854 Issue Published: 1 April 1965 PDF DownloadLoading ...
Complement and immunoglobulins in synovial fluid from synovectomized patients with rheumatoid arthritis.
Authors: O J Mellbye, B Naes, E Munthe
Journal: Annals of the Rheumatic Diseases (1976)

In order to see if the complement (C) consumption and conversion, which are typical of rheumatoid joints, continue after synovectomy, 23 knee joints in which synovectomy had been performed from 4-5 to 6-5 years previously, were studied. The mean ratio of the concentration of C3, C4, and C5 in synovial fluid to that in palsma of the same patient was significantly lower than the corresponding ratio for the total protein content. This was found both in joints with active arthritis and in joints without clinical signs of arthritis, and in both seropositive and seronegative patients. Conversion products of C3 were found in 7 of the synovial fluids. The study thus indicated that the complement alterations in synovectomized joints are very similar to those in nonsynovectomized rheumatoid joints. In one synovial fluid agarose electrophoresis showed multiple sharp bands in the gamma region. By crossed immunoelectrophoresis some bands seemed to contain IgG with one type of light chains only. In plasma of the same patients the bands were much weaker, indicating local production of oligoclonal IgG in the joint.
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner
Authors: W. Wei-Lynn Wong, James E. Vince, Najoua Lalaoui, Kate E. Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine O’Reilly, Philipp J. Jost, James M. Murphy, Warren S. Alexander, Andreas Strasser, David L. Vaux, John Silke
Journal: Blood (2014)
Abstract 3188: Evaluation of clonal origin of malignant mesothelioma/polyclonal origin of malignant mesothelioma
Authors: Sabahattin Comertpay, Rosanna Mezzapelle, Mika Tanji, Oriana Strianese, Harvey I. Pass, Tracey Weigel, Joseph Friedberg, Paul Sugarbaker, Thomas Krausz, Ena Wang, Giovanni Gaudino, Haining Yang, Amy Powers, Barbara Parsons, Sandra Pastorino, Michele Carbone
Journal: Cancer Research (2014)

Abstract Tumors are generally thought to be monoclonal in origin, although this paradigm stemmed decades ago mostly from the study of hematopoietic malignancies and sarcomas. The clonal origin of malignant mesothelioma, a deadly cancer resistant to the current therapies, has never been investigated before. We used the HUMARA (human androgen receptor) assay to examine the pattern of clonality in 14 sporadic and 2 familial Malignant Mesotheliomas (MM). Of 16 specimens studied, 14 were informative and nearly all (13/14) revealed two electrophoretically distinct methylated HUMARA alleles, indicating a polyclonal origin for these tumors. This discovery has important clinical implications, in that an accurate assessment of tumor clonality is key to the design of novel molecular strategies for the treatment of MM. Citation Format: Sabahattin Comertpay, Rosanna Mezzapelle, Mika Tanji, Oriana Strianese, Harvey I. Pass, Tracey Weigel, Joseph Friedberg, Paul Sugarbaker, Thomas Krausz, Ena Wang, Giovanni Gaudino, Haining Yang, Amy Powers, Barbara Parsons, Sandra Pastorino, Michele Carbone. Evaluation of clonal origin of malignant mesothelioma/polyclonal origin of malignant mesothelioma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3188. doi:10.1158/1538-7445.AM2014-3188
A CASE OF FRACTURE OF THE RADIUS TREATED BY EARLY MASSAGE AND MOVEMENT
Authors: J. P. Hastings
Journal: BMJ (1909)

irregular for some minutes after he had walked up and, down a flight of eleven stairs.Inhalation of oxygen markedly lessened the irregularity.Double the climb, in fact, did not have the effect of a single climb without oxygen.In mitral stenosis we have a condition of oxygen want very like that which occurs at high altitudes.