Long-Term Adjuvant Therapy with Tamoxifen in Breast Cancer: How Long Is Long?
Authors: DOUGLASS C. TORMEY
Journal: Annals of Internal Medicine (1987)

Editorials1 May 1987Long-Term Adjuvant Therapy with Tamoxifen in Breast Cancer: How Long Is Long?DOUGLASS C. TORMEY, M.D., Ph.D.DOUGLASS C. TORMEY, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-762 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe article by Fisher and colleagues in this issue ( 1 ) presents data suggesting that long-term adjuvant therapy with the antiestrogen tamoxifen improves the prognosis after surgery for patients with operable node-positive breast cancer. These results were obtained in an extension of their earlier randomized trial that compared a 2-year regimen of Lphenylalanine mustard and fluorouracil with the same regimen plus tamoxifen in patients who had had mastectomy and axillary dissection (2). The addition of tamoxifen in that trial led to a longer time to recurrence.The study reported in this issue consisted of the evaluation of an additional...References1. FISHERBROWNWOLMARK BAN. Prolonging tamoxifen therapy for primary breast cancer: findings from the National Surgical Adjuvant Breast and Bowel Project. Ann Intern Med. 1987;106:649-54. LinkGoogle Scholar2. FISHERREDMONDBROWN BCA. Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer; 5-year results from the National Surgical Adjuvant Breast and Bowel Project Trial. J Clin Oncol. 1986;4:459-71. CrossrefMedlineGoogle Scholar3. TORMEYGRAYTAYLORKNUIMANOLSONCUMMINGS DRSMJF. Postoperative chemotherapy and chemohormonal therapy in women with node-positive breast cancer. NCI Monogr. 1986;1:75-80. Google Scholar4. GOLDHIRSCHGELBER AR. Adjuvant treatment for early breast cancer: the Ludwig breast cancer studies. NCI Monogr. 1986;1:55-70. Google Scholar5. BAUMBRINKLEYDOSSETT MDJ. 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Author, Article, and Disclosure InformationAffiliations: University of Wisconsin Clinical Cancer Center Madison, Wiscon-sin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGynecologic complications associated with long-term adjuvant tamoxifen therapy for breast cancerThe role of tamoxifen in the treatment and prevention of breast cancerAdjuvant Antiestrogen Therapy for Breast Cancer: Past, Present, and FutureLong-term adjuvant tamoxifen therapy for breast cancer: The prelude to preventionBreast cancerClinical experience in the use of the antioestrogen tamoxifen in the treatment of breast cancerOptimisation of antioestrogen therapy: laboratory and clinical conceptsBone mineral density in women with breast cancer treated with adjuvant tamoxifen for at least two years 1 May 1987Volume 106, Issue 5Page: 762-764KeywordsBreast cancerRandomized trialsSurgery Issue Published: 1 May 1987 PDF DownloadLoading ...