tbuckley/cabot-search huggingface dataset:
Sequencing and Combining Systemic Therapies for Pancreatic Neuroendocrine Tumors
Authors: Matthew H. Kulke
Journal: Journal of Clinical Oncology (2015)

Article Tools ONCOLOGY GRAND ROUNDS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2014.59.0927 Journal of Clinical Oncology - published online before print April 13, 2015 PMID: 25870092 Sequencing and Combining Systemic Therapies for Pancreatic Neuroendocrine Tumors Matthew H. KulkexMatthew H. KulkeSearch for articles by this author Show More Program in Neuroendocrine and Carcinoid Tumors, Dana-Farber Cancer Institute, Boston, MA https://doi.org/10.1200/JCO.2014.59.0927 First Page Full Text PDF Figures and Tables © 2015 by American Society of Clinical Oncology
Serum adiponectin is related to plasma high-density lipoprotein cholesterol but not to plasma insulin-concentration in healthy children: the FLVS II study
Authors: Adrien Kettaneh, Barbara Heude, Jean-Michel Oppert, Philipp Scherer, David Meyre, Jean-Michel Borys, Pierre Ducimetiere, Marie-Aline Charles
Journal: Metabolism (2006)
Expression profiling of liver cell lines expressing entire or parts of hepatitis C virus open reading frame
Authors: H Aizaki
Journal: Hepatology (2002)

Although hepatitis C virus (HCV) is a causative agent of liver diseases, its mechanism of pathogenesis is still unclear, mainly because of the lack of adequate cell culture systems to support HCV infection and replication. In this report, we describe development and characterization of human hepatoma cell lines constitutively expressing entire (Hep394) or parts (Hep352, Hep3294) of the HCV open reading frame (ORF). The viral and cellular proteolytic machinery involved in the viral precursor processing was consistently functional, and processed HCV proteins were synthesized in these established cell lines. By using a cDNA microarray analysis coupled with semiquantitative reverse-transcription polymerase chain reaction (RT-PCR), we identified 12 genes up-regulated and 4 genes down-regulated in Hep394 cells. With regard to genes related to cell growth regulation, we found up-regulation of forkhead transcription factor FREAC-1, poly (A) binding protein PABP2, and Ras suppressor Rsu-1. Another category of changes in gene expression includes MHC antigens, which play an important role in the T-cell-mediated immune reaction in the liver. In conclusion, functional genomic approaches comparing expression among the different cell lines expressing parts of the HCV genome may promote our understanding of the molecular basis of pathogenicity of HCV infection. (HEPATOLOGY2002;36:1431–1438).
Scientists “reprogramme” skin cells to create embryonic stem cells
Authors: Geoff Watts
Journal: BMJ (2007)

The drug industry is "burying its head in the sand" when dealing with health in developing countries and denying poorer people access to life saving drugs, a report claims this week.A critical report by the international agency Oxfam says that the drug industry is refusing to change the way it does business in poor countries, despite promising that it would, and is undermining its own future.Oxfam's report looks at the world's top 12 drug companies, including their drug pricing policies, their record in developing drugs that are relevant to health care in poor countries, and their stance on protecting intellectual property rights.The report says that the industry shows various shortcomings, including:• Failure to implement a systematic and transparent tiered pricing policy that is based on people's ability to pay • Continuing to neglect research and development concerning diseases that affect developing countries, and • Inflexibility in protecting intellectual property, which includes challenging poor countries in court to stop them using legal safeguards to protect public health.Oxfam interviewed 12 companies in preparing the report: Abbott, AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Eli Lilly, Johnson & Johnson, Merck, Novartis, Pfizer, Roche, Sanofi-Aventis, and Wyeth
Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation
Authors: Emily Blyth, Leighton Clancy, Renee Simms, Chun K. K. Ma, Jane Burgess, Shivashni Deo, Karen Byth, Ming-Celine Dubosq, Peter J. Shaw, Kenneth P. Micklethwaite, David J. Gottlieb
Journal: Blood (2013)
Invariant NKT Cells Recognize Ragweed Pollen Lipid and Promote Humoral and Cellular Immune Response in a Mouse Model of Allergic Rhinitis
Authors: Mohamed Elfatih Bashir, Abu Bekr Mohamed, Marwa Eltayeb, Fuad M. Baroody, Jayant M. Pinto, Robert M. Naclerio
Journal: Journal of Allergy and Clinical Immunology (2013)
US Supreme Court refuses to intervene in “right to die” case
Authors: Fred Charatan
Journal: BMJ (2005)

The parents of Terri Schiavo, the brain damaged Florida woman who has been on a life support machine since a cardiac arrest 15 years ago, have had to abandon their attempt to save their daughter's life after the US Supreme Court last week refused to hear an emergency appeal from them.

The Supreme Court's decision effectively endorsed a decision by a Florida judge on Tuesday 22 March, which was supported by a panel of appeal judges the next day, …
The Christian Hospital Swindle.
Authors: W. A. Evans
Journal: JAMA (1903)

Chicago, June 3, 1903. <h3>To the Editor:</h3> —The Medicolegal Committee of the Chicago Medical Society wish to make the following statement to the profession of the United States: On Sunday, May 17, Dr. J. B. Murphy brought the Christian Hospital of Chicago to our attention. Dr. Murphy had returned from Washington that morning. In his mail he had found a letter dated May 12, offering him the presidency of the Christian Hospital. This letter was written on a letter head bearing his name as president. In the same mail were a large number of letters from physicians of the far west and southwest, some of which were dated as early as the 12th, calling his attention to the hospital and enclosing various advertising items bearing his name as president. In the main the accompanying letters are very considerate in tone, occasionally one was abusive. On Monday the committee consulted their
Immunogenetic Factors in Skin Cancer
Authors: J. Wayne Streilein
Journal: New England Journal of Medicine (1991)

The malignant degeneration of normal tissues is a multifactorial process in which elements in the host and the environment conspire to produce clinical cancer. Except under rather rare circumstances, no element alone is sufficient. It is generally believed that the relative contributions of host and environment vary considerably both among tumor types and among individual patients. In the case of skin cancer, there is information implicating both host and environmental factors, although that information is still incomplete. From the environmental standpoint, ultraviolet B (UVB) radiation in sunlight is known to make an essential and critical contribution to the development of . . .
Fundamental Approach to Surgical Problems
Authors: A. P. Hovnanian
Journal: JAMA (1962)

This timely reminder to the medical profession describes the patient as a whole, rather than by systems or regional anatomical segments. Emphasis is placed on the basic functional and anatomic pathogenesis of illnesses. The "whys" in the genesis of diseases, treatment, complications, and prognoses are stressed, rather than the "how," "what," "when," or "where." This book deals mainly with discipline of the mind, going beyond facts and findings, looking for underlying reasons which trigger these phenomena. The introduction by Dr. Warner F. Bowers should be read by all medical students as well as by young residents who are starting the long period of learning the art of surgery. The philosophy underlying the book is unreservedly recommended to all who have a role in teaching our present-day surgical students.
Health Planning — Demise or Reformation?
Authors: Henry A. Foley
Journal: New England Journal of Medicine (1981)

For the past three years, I was privileged to serve as administrator of the Health Resources Administration, which was located within the Department of Health and Human Services. I assumed the position two months after Secretary Joseph Califano issued the proposed resource standards of the National Guidelines for Health Planning and the debate about the appropriateness of the standards had commenced. A few of my major responsibilities were to salvage those guidelines, to represent the Carter administration in its efforts to renew the legislation authorizing the National Health Planning and Resources Development Act, and to ensure the continued implementation of . . .
Barrier effects of hyperosmolar signaling in microvascular endothelium of rat lung.
Authors: R Ragette, C Fu, J Bhattacharya
Journal: Journal of Clinical Investigation (1997)

We determined the effects of hyperosmolarity on lung microvascular barrier properties by means of the split-drop technique in single venular capillaries of the isolated, blood-perfused rat lung. Using isosmolar and hyperosmolar test solutions (colloid osmotic pressure = 21 cm H2O), we quantified transcapillary flux at a fixed absorptive capillary pressure, and the capillary hydraulic conductivity (Lp). Loss of barrier function was indicated in flux reversal from isosmolar absorption to hyperosmolar filtration (P < 0. 01), and by hyperosmolarity-induced Lp increase (P < 0.01). Barrier recovery after a 1-min hyperosmolar exposure was delayed > 25 min. The flux reversal was blocked by the tyrosine kinase inhibitors genistein and MDC (P < 0.01). Genistein also inhibited the Lp increase (P < 0.01). Immunoblots of hyperosmolarity-exposed, cultured rat lung microvascular endothelial cells (RLMEC) and of endothelial cells freshly harvested from lungs given hyperosmolar infusions indicated a genistein-inhibitable enhancement of protein tyrosine phosphorylation. Immunoprecipitation studies indicated tyrosine phosphorylation of the mitogen activated protein kinases (MAPK) ERK1 and ERK2 and the adaptor protein Shc in lysates of RLMEC exposed to hyperosmolar conditions. We conclude that in lung venular capillaries hyperosmolarity deteriorates barrier properties, possibly by inducing tyrosine phosphorylation of endothelial proteins.
External Shunts and Internal Fistulas
Authors: KARL D. NOLPH
Journal: Annals of Internal Medicine (1971)

Editorial Notes1 June 1971External Shunts and Internal FistulasKARL D. NOLPH, M.D., F.A.C.P.KARL D. NOLPH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-6-1008 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChronic intermittent extracorporeal hemodialysis became practical with the development of the external arteriovenous shunt by Quinton, Dillard, and Scribner in 1960 (1). With the use of these Teflon, later Silastic-Teflon and recently all Silastic, cannulae, thousands of patients have received this life-sustaining therapy in the past decade. Uncomplicated shunts have minimal effects on cardiac output and, aside from the inconvenience of avoiding trauma or wetting of the shunt area, are well tolerated. Mean shunt survival has been reported by some centers to be as high as 12 to 14 months (2).Yet the shunt that made chronic dialysis possible has...References1. QUINTONDILLARDSCRIBNER WDB: Cannulation of blood vessels for prolonged hemodialysis. Trans Amer Soc Artif Intern Organs 6:104-113, 1960 MedlineGoogle Scholar2. PENDRASSMITH JM: The silastic teflon arterio-venous cannula. Trans Amer Soc Artif Intern Organs 12:222-228, 1966 MedlineGoogle Scholar3. FAROOKIGERGELYMCANINCH MNL: External arteriovenous shunts for intermittent long term hemodialysis: five years experience. Canad Med Ass 103:1371-1374, 1970 MedlineGoogle Scholar4. THOMAS G: Large vessel appliquè arteriovenous shunt for hemodialysis. A new concept. Amer J Surg 120:244-248, 1970 CrossrefMedlineGoogle Scholar5. BRESCIACIMINOAPPEL MJK: Chronic hemodialysis using venipuncture and a surgically created arteriovenous fistula. New Eng J Med 275:1089-1092, 1966 CrossrefMedlineGoogle Scholar6. MERRILLSCHUPAKCAMERON JEE: Hemodialysis in the home. JAMA 190:468-470, 1964 CrossrefMedlineGoogle Scholar7. Editorial: Hemodialysis using an arteriovenous fistula. New Eng J Med 275:1134-1135, 1966 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Missouri Medical Center Columbia, Mo. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVascular access for hemodialysis: A perpetual challengeSepticemia in Patients on Chronic HemodialysisJAY F. DOBKIN, M.D., MICHAEL H. MILLER, M.D., NEAL H. STEIGBIGEL, M.D., F.A.C.P.Blood flow in end-to-side arteriovenous fistulas and saphenous vein graftsBlood Loss from Cannulation Sites during Haemodialysis 1 June 1971Volume 74, Issue 6Page: 1008-1009KeywordsCardiac outputFistulasMedical dialysis Issue Published: 1 June 1971 PDF downloadLoading ...
New Developments in Cardiothoracic Surgery
Authors: Donald G. Mulder
Journal: JAMA (1977)

New and innovative developments in cardiothoracic surgery include the pulmonary effects of certain inotropic drugs, the role of patent ductus closure in neonatal respiratory distress syndrome, the use of immunostimulating agents as adjuvants in the treatment of cancer of the lung, ingenious operative procedures to correct transposition of the great vessels and aortic stenosis, and improved methods to protect and assist the heart during cardiac operations. (<i>JAMA</i>237:2315-2317, 1977)
Metabolite profiles and the risk of developing diabetes
Authors: Thomas J Wang, Martin G Larson, Ramachandran S Vasan, Susan Cheng, Eugene P Rhee, Elizabeth McCabe, Gregory D Lewis, Caroline S Fox, Paul F Jacques, Céline Fernandez, Christopher J O'Donnell, Stephen A Carr, Vamsi K Mootha, Jose C Florez, Amanda Souza, Olle Melander, Clary B Clish, Robert E Gerszten
Journal: Nature Medicine (2011)
Spirulina and Vitamin B12
Authors: V. Herbert, G. Drivas
Journal: JAMA (1982)

<h3>To the Editor.—</h3> A current health food fad involves tablets of<i>Spirulina</i>,<sup>1</sup>a genus of blue-green algae belonging to the family Oscillatoriaceae of the division Cyanophyta,<sup>2</sup>represented in the health food literature to contain large amounts of vitamin B<sub>12</sub>. We subjected three popular brands of 500-mg<i>Spirulina</i>tablets to both the<i>United States Pharmacopeia</i>microbiologic assay for vitamin B<sub>12</sub>and the vitamin B12 radioassay method we recently applied to multivitamin pills.<sup>3</sup> The results are given in the Table. Microbiologic assay would lead one to believe that 500-mg<i>Spirulina</i>tablets contain about 0.25 to 1 μg of vitamin B<sub>12</sub>per tablet, but radioassays, using R binder to measure the total of (cobalamins plus cobalamin analogues) and intrinsic factor to measure cobalamins alone (ie, "true B<sub>12</sub>"), suggest that more than 80% of what appears to be "vitamin B<sub>12</sub>" by microbiologic assay is in fact
PRESS RELEASE OF THE WEEK
Authors: P. MacNair
Journal: BMJ (1995)

Apress release from the Birth Defects Foundation on 30 November 1994 anounced a “major genetic break-through for Noonan syndrome.” The announcement, which covered the successful mapping of the gene for Noonan syndrome and other related syndromes, continued, “An 18 year personal odyssey by a British housewife has lead to a major breakthrough in medical science which offers hope for the future for thousands of parents around the world.” The release resulted in widespread coverage in local and national newspapers and on television and radio.

The press release itself contained no direct explanation as to why mapping …
How to Perform a Lumbar Puncture
Authors: Stephen Piwinski, Wendell Johnson, Michelle Kawasaki
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combining CD19 Redirection and Alloanergization to Generate Tumor-Specific Human T Cells for Allogeneic Cell Therapy of B-Cell Malignancies
Authors: Jeff K. Davies, Harjeet Singh, Helen Huls, Dongin Yuk, Dean A. Lee, Partow Kebriaei, Richard E. Champlin, Lee M. Nadler, Eva C. Guinan, Laurence J.N. Cooper
Journal: Cancer Research (2010)

Abstract Allogeneic hematopoietic stem-cell transplantation can cure some patients with high-risk B-cell malignancies, but disease relapse following transplantation remains a significant problem. One approach that could be used to augment the donor T-cell–mediated antitumor effect is the infusion of allogeneic donor–derived T cells expressing a chimeric antibody receptor (CAR) specific to the B-cell antigen CD19. However, the use of such cells might result in toxicity in the form of graft-versus-host disease mediated by CD19-specific (CD19-CAR) T cells possessing alloreactive endogenous T-cell receptors. We therefore investigated whether nonalloreactive tumor-specific human T cells could be generated from peripheral blood mononuclear cells of healthy donors by the combination of CD19 redirection via CAR expression and subsequent alloanergization by allostimulation and concomitant blockade of CD28-mediated costimulation. Alloanergization of CD19-CAR T cells resulted in efficient and selective reduction of alloresponses in both CD4+ and CD8+ T cells, including allospecific proliferation and cytokine secretion. Importantly, T-cell effector functions including CAR-dependent proliferation and specific target cytolysis and cytokine production were retained after alloanergization. Our data support the application of CD19 redirection and subsequent alloanergization to generate allogeneic donor T cells for clinical use possessing increased antitumor activity but limited capacity to mediate graft-versus-host disease. Immunotherapy with such cells could potentially reduce disease relapse after allogeneic transplantation without increasing toxicity, thereby improving the outcome of patients undergoing allogeneic transplantation for high-risk B-cell malignancies. Cancer Res; 70(10); 3915–24. ©2010 AACR.
Hydrogen Sulfide Improves Neutrophil Migration and Survival in Sepsis via K<sup>+</sup><sub>ATP</sub>Channel Activation
Authors: Fernando Spiller, Maria I. L. Orrico, Daniele C. Nascimento, Paula G. Czaikoski, Fabrício O. Souto, José C. Alves-Filho, Andressa Freitas, Daniela Carlos, Marcelo F. Montenegro, Alberto F. Neto, Sergio H. Ferreira, Marcos A. Rossi, John S. Hothersall, Jamil Assreuy, Fernando Q. Cunha
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Rationale: Recovering the neutrophil migration to the infectious focus improves survival in severe sepsis. Recently, we demonstrated that the cystathionine γ-lyase (CSE)/hydrogen sulfide (H2S) pathway increased neutrophil recruitment to inflammatory focus during sterile inflammation.Objectives: To evaluate if H2S administration increases neutrophil migration to infectious focus and survival of mice.Methods: Sepsis was induced by cecal ligation and puncture (CLP).Measurements and Main Results: The pretreatments of mice with H2S donors (NaHS or Lawesson's reagent) improved leukocyte rolling/adhesion in the mesenteric microcirculation as well as neutrophil migration. Consequently, bacteremia levels were reduced, hypotension and lung lesions were prevented, and the survival rate increased from approximately 13% to approximately 80%. Even when treatment was delayed (6 h after CLP), a highly significant reduction in mortality compared with untreated mice was observed. Moreover, H2S pretreatment prevented the down-regulation of CXCR2 and l-selectin and the up-regulation of CD11b and G protein–coupled receptor kinase 2 in neutrophils during sepsis. H2S also prevented the reduction of intercellular adhesion molecule–1 expression in the endothelium of the mesenteric microcirculation in severe sepsis. Confirming the critical role of H2S on sepsis outcome, pretreatment with dl-propargylglycine (a CSE inhibitor) inhibited neutrophil migration to the infectious focus, enhanced lung lesions, and induced high mortality in mice subjected to nonsevere sepsis (from 0 to ∼80%). The beneficial effects of H2S were blocked by glibenclamide (a ATP-dependent K+ channel blocker).Conclusions: These results showed that H2S restores neutrophil migration to the infectious focus and improves survival outcome in severe sepsis by an ATP-dependent K+ channel–dependent mechanism.
Evidence for hydroxyl radical generation by human Monocytes.
Authors: S J Weiss, G W King, A F LoBuglio
Journal: Journal of Clinical Investigation (1977)

A number of highly reactive oxygen species have been implicated in the oxygen-dependent mechanisms involved in bactericidal activity of phagocytic leukocytes. Hydrogen peroxide and superoxide, two agents known to occur during phagocytosis, are thought to interact to generate hydroxyl radical, singlet oxygen, and other potentially reactive molecules. Using an assay system of ethylene generation from methional, cell preparations of human monocytes were demonstrated to generate hydroxyl radical or a similar agent during phagocytosis of zymosan particles. The generation of ethylene was impaired by agents which reduce superoxide or hydrogen peroxide concentrations as well as by agents reported to be hydroxyl radical scavengers. The ethylene generation did not appear to be dependent on myeloperoxidase in that azide enhanced ethylene generation. Monocytes from a patient with chronic granulomatous disease failed to generate ethylene during phagocytosis. This assay technique may be useful in exploring the metabolic events integral to the bactericidal and inflammatory activity of phagocytic leukocytes.
Targeting Human Epidermal Growth Factor Receptor 2: It Is Time to Kill Kinase Death Human Epidermal Growth Factor Receptor 3
Authors: Javier A. Menendez, Ruth Lupu
Journal: Journal of Clinical Oncology (2007)

Rather than subjecting a 10-year-old boy with advanced differentiated thyroid carcinoma to bronchoalveolar lavage for exclusion of miliary tuberculosis, we would have endeavored to extirpate the papillary thyroid carcinoma en bloc from the thyroid bed at the initial operation in an effort to preclude eventual tracheal, esophageal, and recurrent laryngeal nerve invasion 3 and to maximize the effectiveness of radioiodine therapy.In experienced hands, complete resection of a papillary thyroid carcinoma extending into the juxtathyroidal tissue is often feasible at the initial operation, resulting in sustained local control in the neck.Conversely, the long-term effectiveness of radioiodine therapy on gross residual disease in the thyroid bed of patients with differentiated thyroid carcinoma remains unclear.