tbuckley/cabot-search huggingface dataset:
Diseases in Wax: The History of the Medical Moulage
Authors: S. L Gilman
Journal: BMJ (1995)

Thomas Schnalke, trans Kathy Spatschek Quintessence, pounds sterling138, pp 226 ISBN 0 86715 306 7

In the late 1980s the question of what would be the best way of representing the human body for teaching and research was solved by researchers at the National Library of Medicine in Bethesda, Maryland. They decided to “build” the Visible Man and (eventually) the Visible Woman out of data bits. How can you be absolutely accurate and absolutely realistic? Here is the formula: take a real body (in this case that of an executed criminal), scan it by nuclear magnetic resonance, and make the data available on the Internet. This is the “cutting edge” of body imaging of the 1990s, but like all cutting edges it has a history.

Thomas Schnalke, an assistant professor of the history of medicine at Erlangen-Nuremberg, has presented a prehistory of the Visible Body project without being aware of it. His history of the medical wax moulage is a first rate introduction to the rationale and methods for creating highly realistic, accurate images of the body.

Schnalke's study discusses the origins of this technique within religious imagery. He focuses …
SUBCONVULSIVE ELECTRIC SHOCK TREATMENT OF THE PSYCHOSES
Authors: WALTER ANDERSON THOMPSON
Journal: American Journal of Psychiatry (1942)

In conclusion, subconvulsive electric shock treatment by faradic current may be recommended for those patients who are disturbed, destructive, combative or otherwise difficult to manage. It has been used only in chronic cases but I believe if used early in the course of the disease, it will aid in preventing development of these bad habits. The beneficial effects appear to be on a reality basis and due to the associated discomfort. It must not be used as punishment and careful watch against employment of it as such is to be guarded against. It aids in eliminating restraint, reducing destruction and preventing accidents.
Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes
Authors: Patrick J. Hanley, Conrad Russell Young Cruz, Barbara Savoldo, Ann M. Leen, Maja Stanojevic, Mariam Khalil, William Decker, Jeffrey J. Molldrem, Hao Liu, Adrian P. Gee, Cliona M. Rooney, Helen E. Heslop, Gianpietro Dotti, Malcolm K. Brenner, Elizabeth J. Shpall, Catherine M. Bollard
Journal: Blood (2009)
RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression
Authors: Ramesh S Yadava, Carla D Frenzel-McCardell, Qing Yu, Varadamurthy Srinivasan, Amy L Tucker, Jack Puymirat, Charles A Thornton, Owen W Prall, Richard P Harvey, Mani S Mahadevan
Journal: Nature Genetics (2007)
713 ASSOCIATION OF INTERLEUKIN-18 (IL-18), TUMOR NECROSIS FACTOR-α (TNF-α) AND INTERFERON-γ (IFN-γ) GENES POLYMORPHISMS WITH SEVERITY OF LIVER FIBROSIS IN BRAZILIAN PATIENTS WITH CHRONIC HEPATITIS B
Authors: S.C. Ferreia, S.G.F. Chacha, F.F. Souza, A. Teixeira, N.H. Deghaide, C.T. Mendes, E.C. Castelli, M. Secaf, S. Rodrigues, M.G. Villanova, L.N. Ramalho, S. Zucoloto, E.A. Donadi, A.L. Martinelli
Journal: Journal of Hepatology (2010)
Chronic Cor Pulmonale Associated with Lipoid Pneumonia
Authors: James F. Casey
Journal: JAMA (1961)

The case history reveals several attacks of bronchopneumonia and later cardiac failure. The lipoid etiology was not suspected until autopsy, when special stains showed the presence of mineral oil in the pulmonary parenchyma. Cardiopulmonary studies and blood gas determinations were undertaken. This paper includes a review of literature of lipoid pneumonia and a discussion of the clinical symptomatology. The most unusual aspect of the case was the relationship between lipoid pneumonia and cor pulmonale. Lipoid pneumonia has rarely been reported among the numerous causes of cor pulmonale.
African‐American factor VII‐deficient variants in Georgia (FVII variants)
Authors: Jonathan S. Krauss, Anthony Matthews, Joyce Oliver, Alton Lightsey, Mary H. Jonah, Cary G. Pantazis
Journal: American Journal of Hematology (1994)

Abstract We studied African‐American Factor (FVII)‐deficient variants and carriers in Georgia by measuring their levels of FVII antigen (FVIIAG) and FVII procoagulant (FVIIC). Factor VIIAG was determined using enzyme‐linked immunoassay (ELISA), whereas FVIIC was measured in two ways: 1) by fibrin clotting methods that employed human recombinant (HRFVIIC), human placental (HPFVIIC), rabbit brain (RBFVIIC), and bovine brain (BBFVIIC) thromboplastins; and 2) by an amidolytic method (AMFVIIC). Prothrombin time tests (PT) were also performed by standard methods. These 4 FVII‐deficient patients and 3 carriers demonstrated the following results: PT: 18.2 ± 6.5 sec; FVIIAG: 73.0 ± 14.9; HRFVIIC: 30.6 ± 20.3%; HPFVIIC: 30.5 ± 21.4%; RBFVIIC: 25.3 ± 21.4%; BBFVIIC: 30.6 ± 17.5%; AMFVIIC: 44.1 ± 18.3. We conclude that a group of clinically mild African‐American FVII‐deficient variants exists in Georgia. This group is characterized by the presence of FVIIAG and decreased FVIIC, using a variety of thromboplastins; an excellent correlation was noted for both human thromboplastins. © 1994 Wiley‐Liss, Inc.
Chlordiazepoxide (Librium) and Tests of Thyroid Function
Authors: F. Clark, R. Hall
Journal: BMJ (1970)

The effect of chlordiazepoxide (Librium) on thyroid function was examined in 14 euthyroid patients who required the drug for psychiatric reasons and in six patients with clinically mild thyrotoxicosis. There was no significant difference in results from tests of thyroid iodide trapping (thyroid radioiodine uptake, thyroid clearance, and absolute iodine uptake) or of thyroid hormone release (protein-bound iodine, T3 resin uptake, and free thyroxine index) carried out before and during treatment with the drug over a four-week period. It is suggested that chlordiazepoxide need not be withdrawn before thyroid status and function are assessed in any patient taking the drug.
[618] OPTIMAL PRETREATMENT VIRAL LOAD CUT-OFF TO PREDICT TREATMENT OUTCOME IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH PEGINTERFERON o-2b PLUS RIBAVIRIN
Authors: M. Martinot-Peignoux, M.P. Ripault, S. Maylin, N. Boyer, N. Giuily, C. Castelnau, T. Asselah, M. Marcellin
Journal: Journal of Hepatology (2007)
Role of Endogenous Estrogen in Regulating Airway Hyperresponsiveness Induced by Allergen Inhalation Without Adjuvant
Authors: S. Matsubara, C.H. Swasey, A. Dakhama, J.E. Loader, H. Ohnishi, A. Joetham, A. Balhorn, N. Miyahara, K. Takeda, E.W. Gelfand
Journal: Journal of Allergy and Clinical Immunology (2007)
Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident
Authors: None Takashi lto, None Toshio Seyama, S. Iwamoto, None Terumi Mizuno, NikolaiD. Tronko, IgorV. Komissarenko, EbgenyD. Cherstovoy, None Yukio Satow, None Nobuo Takeichi, None Kiyohiko Dohi, None Mitoshi Akiyama
Journal: The Lancet (1994)
GLOMERULAR PERMEABILITY
Authors: Marilyn G. Farquhar, Steven L. Wissig, George E. Palade
Journal: The Journal of Experimental Medicine (1961)

Ferritin was used as a tracer to investigate pathways and mechanisms for transfer across the various layers of the glomerular capillary wall. Kidney tissue, fixed at intervals of 2 minutes to 2 hours following an intravenous injection of ferritin, was examined by electron microscopy. The observations confirmed the existence of three distinct and successive layers in the glomerular capillary wall (the endothelium, the basement membrane, and the visceral epithelium). In addition, they demonstrated a number of new structural features: namely (a) discrete fibrils in the subendothelial spaces; (b) a characteristic, highly elaborate, cytoplasmic organization in the visceral epithelium; and (c) special structures resembling "desmosomes" in the slits between foot processes. In animals sacrificed at short time intervals (2 to 15 minutes) following ferritin administration, ferritin molecules were found at high concentration in the lumen and endothelial fenestrae, at low concentration in the basement membrane, and in very small numbers within the epithelium. Later (1 to 2 hours), the tracer particles were still present in the lumen and within endothelial fenestrae, and, in addition, had accumulated on the luminal side of the basement membrane, especially in the axial regions of the vessels. Larger numbers of ferritin molecules were also found in the epithelium-in invaginations of the cell membrane at the base of the foot processes, and in various membrane-limited bodies (vesicles, multivesicular bodies, vacuoles, and dense bodies) present within the cytoplasm. These observations suggest that the endothelial fenestrae are patent and that the basement membrane is the main filtration barrier. Since the basement membrane has no demonstrable pores, it is probably not a simple sieve but presumably is a gel-like structure with two fine fibrillar components embedded in an amorphous matrix. Both the epithelium and endothelium may be concerned with building and maintaining this structure. Finally, the intracellular accumulation of particles in the epithelium suggests that the latter acts as a monitor that recovers, at least in part, the small amounts of protein which normally leak through the filter.
Renal effects in cirrhotic patients with avid sodium retention of atrial natriuretic factor injection during norepinephrine infusion
Authors: Salvatore Badalamenti, Gianmario Borroni, Elettra Lorenzano, Pierluigi Incerti, Francesco Salerno
Journal: Hepatology (1992)

The administration of atrial natriuretic factor to patients with cirrhosis, and avid sodium retention causes marked hypotension and blunted kidney responses. To evaluate whether the unresponsiveness of the kidney is caused by a fall in mean blood pressure below a critical value for the renal blood perfusion pressure (80 mm Hg), we studied nine such patients and compared the effects of synthetic atrial natriuretic factor alone (1 micrograms/kg as a bolus) with those of an atrial natriuretic factor combination with infused norepinephrine titrated to raise baseline blood pressure by 15 to 20 mm Hg (182 to 625 ng/kg/min). The administration of atrial natriuretic factor during norepinephrine infusion caused a fall in mean blood pressure to values not less than 80 mm Hg in eight of nine patients, with a slight natriuresis (greater than 5 mumol/min) in five patients but no changes in the other four. The mean urinary sodium output was markedly lower than that previously observed after atrial natriuretic factor injection into normal subjects and into cirrhotic patients without avid sodium retention. Unlike sodium excretion, urine flow rate and free water clearance (which were not affected by atrial natriuretic factor alone) were markedly improved by the coadministration of norepinephrine and atrial natriuretic factor. In four additional patients we studied the urinary electrolyte excretion during a low-dose infusion of atrial natriuretic factor (20 ng/kg/min) to which an infusion of norepinephrine titrated to maintain blood pressure over 80 mm Hg was added. In only one of these four patients urinary sodium output consistently increased during atrial natriuretic factor infusion, and the output increased even more when norepinephrine was added.(ABSTRACT TRUNCATED AT 250 WORDS)
527. Pharmaceutical Plasmid Manufacturing: Development of Economical and Innovative Process Solutions
Authors: Joachim Schorr, Markus Mueller, Juergen Hubbuch, Andreas Frerix
Journal: Molecular Therapy (2006)

The commercialisation of plasmid DNA for gene therapy and DNA vaccination applications will be dependent on the availability of large scale manufacturing technology that allows reasonable Cost- of-Goods in a manufacturing scenario.Here, we present the outcome of process development studies based on the objective to design a price efficient process without compromising on product quality or compliance.Those studies lead to an economical and robust vacuum-based pre-clarification technique, able to remove the shear sensitive KDS precipitate from crude bacterial lysate before loading onto the QIAGEN™ anion exchange resin. A follow on one step chromatography run results in pharmaceutical grade DNA.We also have developed an Aqueous-Two-Phase-Separation (ATPS) step. Using ATPS can further refine the plasmid intermediate to even higher purity specifications for e.g. high-dosage plasmid applications. ATPS has economical benefits in the field of large-scale plasmid manufacturing due to the unique selectivity achieved, combined with low cost of goods. The new ATPS-System is able to deplete an excess of open circular (oc) plasmid topoisomers and genomic host DNA from the plasmid preparation.The combination of ATPS and the QIAGEN one step anion exchange chromatography process enables pharmaceutical grade plasmid production at reduced time-in-the-facility, capital investment and product loss without any compromise on target specifications. The commercialisation of plasmid DNA for gene therapy and DNA vaccination applications will be dependent on the availability of large scale manufacturing technology that allows reasonable Cost- of-Goods in a manufacturing scenario. Here, we present the outcome of process development studies based on the objective to design a price efficient process without compromising on product quality or compliance. Those studies lead to an economical and robust vacuum-based pre-clarification technique, able to remove the shear sensitive KDS precipitate from crude bacterial lysate before loading onto the QIAGEN™ anion exchange resin. A follow on one step chromatography run results in pharmaceutical grade DNA. We also have developed an Aqueous-Two-Phase-Separation (ATPS) step. Using ATPS can further refine the plasmid intermediate to even higher purity specifications for e.g. high-dosage plasmid applications. ATPS has economical benefits in the field of large-scale plasmid manufacturing due to the unique selectivity achieved, combined with low cost of goods. The new ATPS-System is able to deplete an excess of open circular (oc) plasmid topoisomers and genomic host DNA from the plasmid preparation. The combination of ATPS and the QIAGEN one step anion exchange chromatography process enables pharmaceutical grade plasmid production at reduced time-in-the-facility, capital investment and product loss without any compromise on target specifications.
Prophylactic Probiotic May Prevent Colic in Newborns
Authors: Anita Slomski
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Functional Significance of the Human Coronary Collateral Circulation.
Authors: Pantel S. Vokonas
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971The Functional Significance of the Human Coronary Collateral Circulation.Pantel S. Vokonas, M.D., Richard H. Helfant, M.D., Richard Gorlin, M.D., F.A.C.P.Pantel S. Vokonas, M.D.Search for more papers by this author, Richard H. Helfant, M.D.Search for more papers by this author, Richard Gorlin, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-822_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical importance of arteriographically demonstrable collaterals was studied in 61 patients and compared with 58 patients without collaterals. Both groups had significant stenosis (greater than 90%) of one coronary artery with less than 50% stenosis of remaining vessels. A slightly but insignificantly (P< 0.2) higher prevalence of normal resting electrocardiograms occurred in the collaterals group (22 of 61 patients) compared with those without collaterals (16 of 58 patients). However, 26 of 33 subjects with collaterals had a positive two-step exercise test compared with 14 of 29 without collaterals (P< 0.05), and 26 of 37 patients in the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 822-822KeywordsCoronary arteriesElectrocardiographyExerciseStenosis Issue Published: 1 May 1971 PDF downloadLoading ...
Abstract LB-71: Poke, Tweet, Share, Tag: A New Generation of Cancer Advocacy
Authors: Leslie Hammersmith
Journal: Cancer Research (2011)

Abstract After a diagnosis of cancer, a whole new, lasting identity imprints itself on you, especially if you're still young. Cancer in young adults brings a set of unique issues, including dealing with a delayed diagnosis, having access to clinical trials, finding age-appropriate peer support, feelings of isolation, and finding some kind of balance between survivorship and feeling cured. Encouraging, supporting and educating a generation of young advocates and survivors requires the attention of the medical community and mentoring from experienced advocates. Building credibility within the scientific community is crucial to establishing the influence of a community of survivors typically underrepresented. Significant challenges exist for the medical community to be effective disseminators of cancer research information to generations 40 years and under. It also takes time for the young advocate to understand the many facets of engagement as a patient advocate. This poster will describe the experiences of a young breast cancer survivor, diagnosed at age 36, as she discovers how becoming an advocate for young women dealing with breast cancer in her community connected her to the science, politics, and ethics of the medical community. Generational expectations combined with professional and cultural differences between the young patient and medical community lead her to find ways to help educate her medical providers, cancer clinics, and fellow patients. The disappointment of finding that many research studies have not considered the issues unique to breast cancer in younger women and the revelation that awareness of breast cancer in women under 40 is minimal inspired her to seek out ways to increase her understanding of the science and improve her understanding of how the medical teams work. This poster will also discuss other opportunities for young advocates to add value to the science of cancer research and its impact on the patient. These opportunities include volunteering as a Patient Advocate with NCCTG through her local Cancer Center, serving as the patient advocate who reviews all research protocols being considered for deployment in her area, seeking out valuable professional development opportunities such as programs through Research Advocacy Network's Research Advocate Institute, and establishing a local affiliate of Young Survival Coalition to link communities of survivors with national resources and education. Through pokes, tweets, tagging, and sharing, she uses media to connect the experience of the young survivor to the science of accelerating progress against cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-71. doi:10.1158/1538-7445.AM2011-LB-71
Assessment of patients aged over 75 in general practice.
Authors: J. Tremellen
Journal: BMJ (1992)

To evaluate the assessment scheme for people aged 75, to establish doctors' and nurses' views on the value of the assessment scheme, and to seek patients' opinions on elderly assessments.Data on the assessment process were collected from individual practices. Questionnaires were sent to doctors and practice nurses undertaking assessments and to a sample of elderly patients.31,565 patients aged 75 and over and all doctors registered with Wiltshire Family Health Services Authority, as well as practice nurses assessing elderly patients. A 2% random sample of elderly patients was selected to answer questions on patient satisfaction.Numbers of patients accepting the invitation for assessment, who carried out the assessments and where, what unmet needs were identified, and by whom.20,192 patients (64%) accepted the assessment offer. Doctors carried out 8786 assessments and nurses 10,779. Although 12,317 (61%) were carried out in the home, nurses did most domiciliary assessments (7122/11,883). Nurses with extra qualifications identified the highest number of unmet needs (400/1000 visits). 155 of 228 (68%) doctors thought assessments unnecessary whereas 25 of 48 (52%) of nurses thought them important. 93% of patients found assessment useful.Doctors see no merit in the scheme; most undertake assessments opportunistically and pick up few new problems. Nurses who see it as important require further training to fit them to do home visits confidently. Patients who were assessed found it worth while. The case for developing a specialist community nurse for elderly people should be investigated.