tbuckley/cabot-search huggingface dataset:
Hypertrophic Cardiomyopathy and Human Leukocyte Antigen Linkage
Authors: John R. Darsee, Steven B. Heymsfield, Donald O. Nutter
Journal: New England Journal of Medicine (1979)

To determine whether hypertrophic cardiomyopathy is associated with a human leukocyte antigen (HLA) phenotype, we tissue-typed 70 unrelated afflicted patients and 86 of their asymptomatic family members (from nine separate kindreds). Forty-five per cent of the white patients had B-12 antigen as compared to 23 per cent in matched control subjects; 69 per cent of black patients had a B 5-complex antigen as compared to 33 per cent in matched controls. Patients with a B-12 or B5-complex antigen were nonhypertensive and had family members with the disease. Patients without these antigens were severely hypertensive and had no affected family members. Linkage analysis of six families revealed a lod score of 7.7 for asymmetric septal hypertrophy and the HLA region of chromosome 6.
Specific skin lesions in a patient with Niemann-Pick disease
Authors: M. TOUSSAINT, W.-I. WORRET, M. DROSNER, K.-H. MARQUARDT
Journal: British Journal of Dermatology (1994)

We report a patient with Niemann‐Pick disease who developed papular lesions on the face. These showed ultrastructural findings typical of this disorder. Specific skin lesions such as these are an extremely rare manifestation of Niemann‐Pick disease.
Critical Diagnostic Pathways in Radiology: An Algorithmic Approach
Authors: Guillermo C. Geisse
Journal: JAMA (1982)

With the advent of new technology, the complexity and interrelationship of multiple diagnostic procedures currently available can be a continuous source of confusion, particularly since many of the modalities can achieve similar results. In radiology, this technological explosion has revolutionized the specialty. Because of the cost, complexity, and similarity of the results of some of these procedures, many hospitals have developed algorithms for a rational and cost-effective use of the available modes. The editors have compiled algorithms for 28 common clinical problems by 40 distinguished authors who represent many of the leading institutions in this country and Great Britain. The authors first analyze the clinical and laboratory findings of a given problem. Then, the available diagnostic or imaging modalities are described, ranging from the simpler to the more complex techniques. At the end of the chapter, one or several algorithms, depending on the problem, are developed. In general, the text
Training General Internists and “STARS”
Authors: Sheila Feit
Journal: Annals of Internal Medicine (1995)

Letters1 January 1995Training General Internists and “STARS”Sheila Feit, MD and Mort Rubinstein, MDSheila Feit, MDSyosset, NY 11791Search for more papers by this author and Mort Rubinstein, MDSyosset, NY 11791Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-1-199501010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We were amused to learn of the latest training track designations at the University of California [1]. Most medicine trainees will be in “general internal medicine” and the rest, in the STAR program. Those who are chosen for a fourth year of specialization after general training (largely to learn procedures) are guaranteed faculty appointments (presumably, generalists are not).Annals seems to advocate producing more general internists. Wouldn't you rather be a “STAR”?References1. Fogelman AM. Strategies for training generalists and subspecialists. Ann Intern Med. 1994; 120:579-83. Google Scholar Author, Article, and Disclosure InformationAffiliations: Syosset, NY 11791 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1995Volume 122, Issue 1Page: 72-73 Issue Published: 1 January 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
US and Germany give late support to WHO tobacco accord
Authors: F. Fleck
Journal: BMJ (2003)

<h3>Background</h3> Little is known about burns in Iraq. This study was undertaken to investigate epidemiology of burn injuries in Sulaymaniyah province with 1.7 million people. <h3>Methods</h3> A prospective study from November 2007 to November 2008 involving all patients attending for a new burn injury. <h3>Results</h3> 2975 patients were recruited (male 52%, female 48%; median age 18 years). All-age incidence of burns was 389/100 000 person-years (pys) and 1044/100 000 pys in preschool children. The mechanisms of injury included scalds (53%), flame (37%), contact (7%), chemical (1%), electrical (1%) and explosives (1%). Most burns occurred at home (83%; male 68%, female 96%). There were 884 admissions (43/100 000 pys) with a significantly higher admission rate in females (males 37, females 49) and the highest rate in preschool children (95/100 000 pys). Flame injuries accounted for most women admissions (91%) and scalds for most child admissions (84%). Overall mortality was 8/100 000 pys (males 2, females 14). Median total body surface area (TBSA) burnt was 18% and median hospital stay was 8 days. In-hospital mortality was 28%. Adjusted ORs for death were 36.4 (95% CI 15.9 to 83.3) for TBSA burnt ≥40%; 5.4 (95% CI 1.7 to 18.5) for age of 60 and over; 3.6 (95% CI 1.7 to 7.3) for inhalation injury; 5.6 (95% CI 2.5 to 12.9) for self-inflicted burns and 3.0 (95% CI 1.3 to 6.8) for autumn season. <h3>Conclusion</h3> Burns are an important public health problem in Sulaymaniyah with higher morbidity in children and mortality in women. Preventive interventions are needed focusing on childhood scalds and flame injuries in women.
Integrated detection and population-genetic analysis of SNPs and copy number variation
Authors: Steven A McCarroll, Finny G Kuruvilla, Joshua M Korn, Simon Cawley, James Nemesh, Alec Wysoker, Michael H Shapero, Paul I W de Bakker, Julian B Maller, Andrew Kirby, Amanda L Elliott, Melissa Parkin, Earl Hubbell, Teresa Webster, Rui Mei, James Veitch, Patrick J Collins, Robert Handsaker, Steve Lincoln, Marcia Nizzari, John Blume, Keith W Jones, Rich Rava, Mark J Daly, Stacey B Gabriel, David Altshuler
Journal: Nature Genetics (2008)
The race against time
Authors: S. Vaisrub
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Challenge to the Health-Insurance Industry
Authors: Benson B. Roe
Journal: New England Journal of Medicine (1982)

BY now it is difficult to argue against the proposition that the cost of health care is too high. The question is, What can be done about it? More to the point, Who is capable of doing something about it?Although the problem has received substantial attention in both the professional and popular press, organized medicine's only response has been the "voluntary effort." This position, which might be described as the hope that physicians will exercise self-restraint to cure the problem, is, of course, exactly what has not worked so far.One convenient excuse for neglecting the problem is the . . .
Evidence-Based Recommendations for Cancer Fatigue, Anorexia, Depression, and Dyspnea
Authors: Sydney M. Dy, Karl A. Lorenz, Arash Naeim, Homayoon Sanati, Anne Walling, Steven M. Asch
Journal: Journal of Clinical Oncology (2008)

Purpose The experience of patients with cancer often involves symptoms of fatigue, anorexia, depression, and dyspnea. Methods We developed a set of standards through an iterative process of structured literature review and development and refinement of topic areas and standards and subjected recommendations to rating by a multidisciplinary expert panel. Results For fatigue, providers should screen patients at the initial visit, for newly identified advanced cancer, and at chemotherapy visits; assess for depression and insomnia in newly identified fatigue; and follow up after treatment for fatigue or a secondary cause. For anorexia, providers should screen at the initial visit for cancer affecting the oropharynx or gastrointestinal tract or advanced cancer, evaluate for associated symptoms, treat underlying causes, provide nutritional counseling for patients undergoing treatment that may affect nutritional intake, and follow up patients given appetite stimulants. For depression, providers should screen newly diagnosed patients, those started on chemotherapy or radiotherapy, those with newly identified advanced disease, and those expressing a desire for hastened death; document a treatment plan in diagnosed patients; and follow up response after treatment. For general dyspnea, providers should evaluate for causes of new or worsening dyspnea, treat or symptomatically manage underlying causes, follow up to evaluate treatment effectiveness, and offer opioids in advanced cancer when other treatments are unsuccessful. For dyspnea and malignant pleural effusions, providers should offer thoracentesis, follow up after thoracentesis, and offer pleurodesis or a drainage procedure for patients with reaccumulation and dyspnea. Conclusion These standards provide a framework for evidence-based screening, assessment, treatment, and follow-up for cancer-associated symptoms.
785 INNATE SIGNALING BY HEPATITIS C VIRUS IS RIG-I AND MDA5 DEPENDENT AND MODULATED BY NS5A DOMAIN II
Authors: M.-S. Hiet, O. Bauhofer, M. Zayas-Lopes, A. Ruggieri, F. Eberle, Y. Tanaka, P. Schirmacher, V. Lohmann, M. Binder, R. Bartenschlager
Journal: Journal of Hepatology (2012)
Clinical trial of a bedside CK-MB/myoglobin panel for the early diagnosis of acute myocardial infarction
Authors: P. Liu, E. Yu, S. Polsky, I. Wheller, E. Wang, P. Cho, Y. Gawad, M. Iwanochko, P. McLaughlin, A.S. Detsky
Journal: Journal of the American College of Cardiology (1998)
Correlation of the Antemortem Coronary Arteriogram and the Postmortem Specimen
Authors: ZEEV VLODAVER, ROBERT FRECH, ROBERT A. VAN TASSEL, JESSE E. EDWARDS
Journal: Circulation (1973)

Correlative studies were carried out on the coronary arteriograms made during diagnostic procedures and on the specimens obtained at necropsy in 10 cases of coronary heart disease. Of the 134 segments of coronary arteries available for both studies, 44 (33%) were given false-negative arteriographic diagnosis of obstructive atherosclerosis. Factors which may underlie this discrepancy include (1) radiographic technic, (2) projection used, (3) a slitlike lumen adjacent to the atheroma, (4) comparison of severely obstructed segments involved but less severely obstructed, and (5) misinterpretation from the specimen of obstruction present in life.
Immunoelectronmicroscopic differentiation of linear IgA bullous dermatosis of adults with coexistence of IgA and IgG deposition from bullous pemphigoid
Authors: Atsuko Adachi, Masahiro Tani, Shuho Matsubayashi, Koichi Shibata, Tatsuya Horikawa, Yozo Murata, Kimiko Kumano
Journal: Journal of the American Academy of Dermatology (1992)
Fight against malaria slowed in 2012 as funding fell
Authors: A. Gulland
Journal: BMJ (2012)

Recent gains in combating malaria are being threatened by a shortfall in funding, a report by the World Health Organization has warned.

New funding is urgently needed, it says, because the largest source of money to fight the disease, the Global Fund to Fight Aids, Tuberculosis and Malaria, has dried up over the past few years, says the World Malaria Report 2012 .1 In 2009 the Global Fund disbursed $1bn (£0.6bn; €0.8bn), but this fell to just over $500m in 2011. Its funding is projected to increase over the next few years.

Total funding for malaria control (domestic and international) is projected to remain at less than $2.7bn between 2013 and 2015, substantially below the $5.1bn needed to achieve universal coverage of antimalarial …
Written information for treating minor illness
Authors: D A Fitzmaurice
Journal: BMJ (2001)

General practice pp 1214, 1218 

Written information, particularly in the form of leaflets, has usually been seen as an adjunct to verbal information in the treatment of specific illnesses, such as back pain.1 Two papers in this week's BMJ take this concept a stage further and investigate the use of patient information leaflets as prophylaxis against patients presenting with symptoms of minor illness. 2 3 This exploration is welcome because, although leaflets are widely used, there is little evidence about their usefulness.

Written information may complement verbal messages, thus enhancing concordance and encouraging behaviour change.4 Patients will vary in the quantity of information they want, and the professional has a duty to deliver it at an appropriate level for each patient, while the Patients Charter's also states that patients have a right to be as informed as they wish.5 The quality of the written information, however, is not always ideal. One study showed that the British …
Need for immediate computed tomography in older people with coagulopathy and minor brain injury
Authors: P. Chiquito-Lopez, O. Bannon
Journal: BMJ (2014)

National Institute for Health and Care Excellence (NICE) head injury guidelines 2014 consider the use of warfarin alone as an indication for computed tomography (CT) of the head within eight hours of a minor brain injury (Glasgow coma scale >12). The guidelines exclude the use of antiplatelet agents as an indication for early imaging.1 2 However, NICE did not appraise the following publications on the use of clopidogrel in elderly people with a …
Aid after disasters: Evidence for psychosocial services needs strengthening
Authors: Debarati Guha-Sapir, Wilbert van Panhuis, Joel Lagoutte
Journal: BMJ (2005)

EDITOR—The editorial by van Ommeren et al on aid after disasters is right on the mark.1 The psychosocial component in emergency relief action has increased recently. Donors clearly feel morally bound to provide funding for psychosocial relief, although many aid providers are not necessarily qualified for these services, in the process discrediting those who are.

From an epidemiological perspective, the …
A Laboratory Year for Clinicians?
Authors: Gregory P. Wanger
Journal: JAMA (1982)

Recently there has been a movement by the American Board of Pathology to reestablish a clinical internship year for pathology residency programs. The intent is to broaden pathologists' experience and facilitate interaction with their peers in clinical medicine. As residents in pathology, we believe the emphasis is misplaced and ask instead: Why not a laboratory year for the clinician?  In our clinical experience (a former family practice resident and an American Board of Internal Medicine-certified internist), we have recognized the increasing reliance on laboratory tests for defining, diagnosing, and managing disease. As pathologists, however, we are confronted with the overuse and the misuse of laboratory tests. Inappropriate use of the laboratory can adversely affect the cost of medical care as well as the quality of that care. Clinical skills seem to have taken a back seat. Routine admission batteries on many services are now the norm. In our institution, for
THE LYMPHATICS OF THE DENTAL REGION
Authors: FREDERICK B. NOYES
Journal: JAMA (1918)

In place of the usual review of the progress of dental science and art, in the year past, which is given in a chairman's address, your chairman has decided to present a report of the work done in the Histological Laboratory of the College of Dentistry of the University of Illinois in the last three years. Two years ago, at the Detroit session, the first of this work was reported to this section. First, I want to say that the technical work has been done by Dr. Dewey, in my laboratory, and she has prepared the review of the literature. <h3>THE LYMPHATIC SYSTEM</h3> Schweitzer<sup>1</sup>deserves the credit of first demonstrating, by injection, the presence of lymphatic vessels in the dental pulp and peridental membrane. Our work has corroborated his results, and filled out some of the gaps in his findings, especially in showing through its entire extent the drainage
Europe's life expectancy rises by five years, but health inequalities remain
Authors: A. Gulland
Journal: BMJ (2013)

Life expectancy increased by five years to 76 years between 1980 and 2010 across the World Health Organization’s Europe region, but major health inequalities remain, says WHO.

WHO’s European Health Report 2012 describes this gain in life expectancy as a “major success” for the 53 countries of the region, which extends to Israel in the south and Kazakhstan in the east.1 It predicts that average life expectancy at birth will increase to nearly 81 years by 2050. However, average life expectancy at birth differs widely between countries, ranging from 82.2 years in Switzerland to 68.7 years in Kazakhstan.

The difference between men and women remains, with women’s life expectancy reaching an average of 80 years in 2010, while men averaged …
Anthralin: chemical instability and glucose-6-phosphate dehydrogenase inhibition
Authors: D. CAVEY, J.C. CARON, B. SHROOT
Journal: British Journal of Dermatology (1981)

Journal Article Anthralin: chemical instability and glucose‐6‐phosphate dehydrogenase inhibition Get access D. CAVEY, D. CAVEY Centre International de Recherches Dermatologiques, Sophia Antipolis, 06565 Valbonne Cédex France Search for other works by this author on: Oxford Academic Google Scholar J.C. CARON, J.C. CARON Centre International de Recherches Dermatologiques, Sophia Antipolis, 06565 Valbonne Cédex France Search for other works by this author on: Oxford Academic Google Scholar B. SHROOT B. SHROOT Centre International de Recherches Dermatologiques, Sophia Antipolis, 06565 Valbonne Cédex France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue s20, 1 August 1981, Pages 15–19, https://doi.org/10.1111/j.1365-2133.1981.tb00992.x Published: 01 August 1981
Postmenopausal Bone Loss Is Prevented by Treatment with Low-Dosage Estrogen with Calcium
Authors: BRUCE ETTINGER
Journal: Annals of Internal Medicine (1987)

Bone mass was measured prospectively in 73 women during the period immediately after menopause. By comparing the rates of loss at three skeletal sites, we assessed the protective effects of calcium supplements given alone or combined with low-dosage estrogen therapy. After 2 years of follow-up, spinal trabecular mineral content, measured by quantitative computed tomography, decreased by a mean of 9.0% (p = 0.002 compared with baseline) in untreated women and a mean of 10.5% (p = 0.0001) in women given calcium supplements alone. By contrast, women given conjugated estrogens, 0.3 mg/d, with calcium supplements showed an insignificant increase of 2.3%. Significant losses of a lesser magnitude were seen in the appendicular cortical skeleton of women not receiving therapy and in those receiving calcium alone, but no significant changes were observed in women receiving estrogen with calcium.
Should treatment for heart failure with preserved ejection fraction differ from that for heart failure with reduced ejection fraction?
Authors: P. Jong, R. McKelvie, S. Yusuf
Journal: BMJ (2010)

Heart failure with preserved ejection fraction (HF-PEF) accounts for about half of all cases of heart failure.1 Population based studies have shown that patients with HF-PEF have high rates of mortality (20-30% risk at one year)2 3 and readmission to hospital (30% risk at 60-90 days),4 which are similar to the rates for patients with heart failure with reduced ejection fraction (HF-REF). When compared with patients with HF-REF, those with HF-PEF are older, more often female, and more likely to have hypertension and atrial fibrillation, but are less likely to have coronary artery disease.2 3 Identifying patients with HF-PEF can be difficult, however, because heart failure presents in many different ways and the diagnostic criteria that define this syndrome are complex.5 The guideline from National Institute for Health and Clinical Excellence has proposed detailed guidance on diagnosis.6 In practice, the diagnosis of HF-PEF is often made in patients with symptoms and signs of heart failure who have preserved left ventricular ejection fraction. Furthermore, the evidence that supports treatment for HF-PEF is much weaker than that supporting treatment for HF-REF. To date, results from existing clinical trials of HF-PEF have been largely inconclusive, and treatments that have been shown to reduce morbidity and mortality in patients with HF-REF showed either no or only marginal benefits in patients with HF-PEF.

To clarify whether treatments that are beneficial in HF-REF may also be beneficial in HF-PEF, we searched Medline, Embase, and the Cochrane Library for all adequately powered randomised controlled trials of treatments for chronic heart failure (HF-PEF or HF-REF) that had reported both mortality and admission to hospital as their primary outcomes. We found no meta-analyses of treatments for HF-PEF, so we depended on studies that would provide the most robust and unbiased estimates of the …
Lisa H.: The True Story of an Extraordinary and Courageous Woman
Authors: Joseph E. Murray
Journal: JAMA (1986)

This book is the biography of a woman who was born with severe facial neurofibromatosis. Subjected to social and psychic hurts from infancy, she underwent 16 operations by age 21 years, five in the most recent two years. These latter operations received national attention, because the public relations department of the hospital contacted a sensitive reporter who interviewed the patient and her family and friends. He later recorded the deliberations and observed the operations performed by the dedicated and skilled team of physicians who attempted to correct the conditon. The cruel insults by adults in public areas like shopping centers and buses, the physical abuse by children in playgrounds, Lisa's almost nightly silent tears, and the anguish of her devoted family are all delicately, albeit painfully, recorded. Halloween, Valentine's day, and school dances always intensified her plight. On the positive side are the love, devotion, and care given by her
Fractured Shaft of Fcmur Complicated by Multiple Systemic Emboli
Authors: W. Laurence
Journal: BMJ (1952)

AGRANULOCYTOSISRr general weakness which had persisted ever since.Her appetite had deteriorated during the last three months.In March she had a short course of sulphonamides for a septic finger, and again ten days later for a boil on her back
Spectrum of Alcohol-Induced Myocardial Damage Detected by Indium-111–Labeled Monoclonal Antimyosin Antibodies
Authors: Manel Ballester, Vicens Martí, Ignasi Carrió, Damià Obrador, Conxa Moya, Guillem Pons-Lladó, Lluis Bernà, Ruben Lamich, Maria Rosa Aymat, Manel Barbanoj, Josep Guardia, Francesc Carreras, Claudi Udina, Josep M Augé, Jaume Marrugat, Gaietà Permanyer, Josep M Caralps-Riera
Journal: Journal of the American College of Cardiology (1997)