tbuckley/cabot-search huggingface dataset:
Primary cutaneous follicle center lymphoma of the arm with a novel chromosomal translocation t(12;21)(q13;q22): A case report
Authors: Tomislav M. Jelic, Paula K. Berry, Steven J. Jubelirer, Lisa Plumley, Paul H. Hartel, Oscar C. Estalilla, Ho-Huang Chang
Journal: American Journal of Hematology (2006)

We report a reciprocal translocation between the long arms of chromosomes 12 and 21, t(12;21)(q13;q22), in a patient with primary cutaneous follicle center lymphoma. Follicle center lymphoma of the skin and follicle center cell lymphoma of the lymph node are morphologically and immunophenotypically very similar. However, the clinical behavior and prognosis of these tumors are different due to the molecular basis of these malignancies. Follicle center cell lymphoma of the lymph node is determined by the presence of a unique translocation between chromosomes 14 and 18, t(14;18)(q32;q21), BCL-2-JH gene rearrangement, that is not present in primary cutaneous follicle center lymphomas. Chromosomal translocations in the primary skin lymphomas have not been previously reported. We hope that our discovery of a new translocation t(12:21)(q13q22) will encourage further investigation into the molecular basis of this translocation and other cytogenetic abnormalities in primary cutaneous B-cell lymphomas. Am. J. Hematol. 81:448–453, 2006. © 2006 Wiley-Liss, Inc.
Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A2
Authors: Jintang Sun, Yan Zhang, Meixiang Yang, Yun Zhang, Qi Xie, Zewu Li, Zhaogang Dong, Yongmei Yang, Biping Deng, Alei Feng, Weixu Hu, Haiting Mao, Xun Qu
Journal: Cellular and Molecular Immunology (2009)
Serum concanavalin-A binding in rheumatoid arthritis.
Authors: M F Martin, P A Dieppe, H E Jones, C Warren, J Whicher, J Kohn
Journal: Annals of the Rheumatic Diseases (1982)

A nephelometric assay of concanavalin-A binding of serum acute phase proteins (con-A binding) has been used in cross-sectional and sequential studies of disease activity in rheumatoid arthritis (RA). Con-A binding correlated well with blood viscosity, C-reactive protein, and other individual acute phase reactants in patients with active RA. Twenty-four patients were treated for 6 months with D-penicillamine and assessed clinically and seriologically. Clinical improvement was accompanied by significant falls in both C-reactive protein and con-A binding, although the serological changes did not always occur in parallel in individual patients. The advantages of this simple, cheap assay of acute phase proteins are discussed.
Increasing Incidence of Thyroid Cancer in the United States, 1973-2002
Authors: Louise Davies, H Gilbert Welch
Journal: JAMA (2006)

Increasing cancer incidence is typically interpreted as an increase in the true occurrence of disease but may also reflect changing pathological criteria or increased diagnostic scrutiny. Changes in the diagnostic approach to thyroid nodules may have resulted in an increase in the apparent incidence of thyroid cancer.To examine trends in thyroid cancer incidence, histology, size distribution, and mortality in the United States.Retrospective cohort evaluation of patients with thyroid cancer, 1973-2002, using the Surveillance, Epidemiology, and End Results (SEER) program and data on thyroid cancer mortality from the National Vital Statistics System.Thyroid cancer incidence, histology, size distribution, and mortality.The incidence of thyroid cancer increased from 3.6 per 100,000 in 1973 to 8.7 per 100,000 in 2002-a 2.4-fold increase (95% confidence interval [CI], 2.2-2.6; P<.001 for trend). There was no significant change in the incidence of the less common histological types: follicular, medullary, and anaplastic (P>.20 for trend). Virtually the entire increase is attributable to an increase in incidence of papillary thyroid cancer, which increased from 2.7 to 7.7 per 100,000-a 2.9-fold increase (95% CI, 2.6-3.2; P<.001 for trend). Between 1988 (the first year SEER collected data on tumor size) and 2002, 49% (95% CI, 47%-51%) of the increase consisted of cancers measuring 1 cm or smaller; 87% (95% CI, 85%-89%) consisted of cancers measuring 2 cm or smaller. Mortality from thyroid cancer was stable between 1973 and 2002 (approximately 0.5 deaths per 100,000).The increasing incidence of thyroid cancer in the United States is predominantly due to the increased detection of small papillary cancers. These trends, combined with the known existence of a substantial reservoir of subclinical cancer and stable overall mortality, suggest that increasing incidence reflects increased detection of subclinical disease, not an increase in the true occurrence of thyroid cancer.
A1.11 T cells in the infrapatellar fat pad of osteoarthritis patients as a source of IL-6 in the joint
Authors: AJ de Jong, JC Kwekkeboom, SN Andersen, M Kloppenburg, REM Toes, A Ioan-Facsinay
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> The infrapatellar fat pad (IFP) is an adipose tissue organ present in the knee next to the synovium and cartilage, thereby constituting a potential player in the pathological processes in the osteoarthritic joint. Obesity-associated changes occur in IFP and this supports the hypothesis that IFP could mediate the association between obesity and the development and progression of osteoarthritis (OA). Interestingly, these changes were observed in the stromal vascular fraction (SVF) rather than adipocytes. As this fraction contain many different types of immune cells, we characterised the SVF of the IFP in OA patients phenotypically and functionally. <h3>Materials and methods</h3> IFP samples were obtained from knee OA patients (N = 43) undergoing joint replacement surgery (58.1% women; mean (SD) age 66.4 years (10.9); mean (SD) BMI 29.2 kg/m<sup>2</sup> (5.7)). The SVF was isolated and cells were characterised based on surface markers expression and cytokine production using flow cytometry. <h3>Results</h3> Characterisation of the SVF of IFP showed the presence of various immune cells in this tissue, whereby macrophages and T cells were most abundant. Interestingly, flow cytometry analyses of <i>ex vivo</i> cytokine production by different cells revealed a subpopulation of CD4<sup>+</sup> T cells that were able to produce IL-6 without further stimulation. These IL-6 producing CD4<sup>+</sup> T cells expressed CD69, indicating recent activation. Upon polyclonal stimulation, CD4<sup>+</sup> T cells were able to secrete IFNγ, TNFα, and IL-4. However, IL-6 producing CD4<sup>+</sup> T cells did not secrete these cytokines. Furthermore, chemokine receptor expression revealed that these IL-6 producing T cells could not be categorised as conventional T helper 1 (Th1), Th2, Th17 or Tfh cells. These data indicate that IL-6-secreting T cells are a distinct population of T cells. Finally, we have also studied whether these IL-6 producing T cells are also present in other tissues. Indeed, we have found these cells also in sc adipose tissues and synovium of OA patients, but only at low frequencies in blood. <h3>Conclusion</h3> In conclusion, we have found a novel population of CD4<sup>+</sup> T cells which secrete IL-6 directly <i>ex vivo</i> and are in an activated state, indicating that these CD4<sup>+</sup> T cells might recognise adipose tissue antigens and could be involved in the inflammatory processes present in human adipose tissue. Moreover, they are a source of IL-6 in the OA joint, thereby potentially contributing to joint inflammation.
Abstract 181: Hepatic retinoid signaling in mouse hepatocarcinogenesis models.
Authors: Yohei Shirakami, William S. Blaner, Masahito Shimizu, Hisataka Moriwaki, Mitsuru Seishima
Journal: Cancer Research (2013)

Abstract Retinoids are known to possess anti-cancer effects and a clinical trial of a synthetic retinoid for hepatocellular carcinoma (HCC) is ongoing recently in Japan. Hepatic retinoid metabolism is usually impaired during development of liver diseases. Loss of retinoid-containing lipid droplets upon hepatic stellate cell (HSC) activation is one of the first events in the development of liver diseases and retinoid stores are progressively lost from HSCs leading to hepatic fibrosis, cirrhosis, and HCC. In the present study, we employed two types of genetically-modified mice for investigating hepatic retinoid metabolism and signaling in diethylnitrosamine (DEN)-induced mouse hepatocarcinogenesis models. One is lecithin:retinol acyltransferas (LRAT) knockout (KO) mouse which lacks HSC lipid droplets and has much less hepatic retinoid stores, and the other is a transgenic mouse which expresses dominant negative form of retinoic acid receptor (dnRAR) to block retinoid signaling in the liver. Male 15 day-old mice were given intraperitoneal injections of DEN (25 mg/kg body weight). Eight-month-old DEN-treated Lrat KO mice showed lower liver tumor incidence and dnRAR transgenic mice showed higher incidence than that of respective control mice. In the acute phase after DEN injection, dnRAR transgenic mice exhibited higher hepatic levels of inflammatory cytokines. Two days after DEN injection, lower serum levels of alanine aminotransferase and decreased hepatic levels of cyclin D1 were observed in Lrat KO mice. Lrat KO mice also exhibited increased levels of retinoic acid-responsive genes, including p21, lower levels of cytochrome P450 enzymes required for DEN-bioactivation, and higher levels of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT). Our results indicate that Lrat KO mice, instead of almost no hepatic retinoid storage, are less susceptible to DEN-induced hepatocarcinogenesis due to increased hepatic retinoid signaling which is accompanied by higher expression of p21 in the liver. In conclusion, retinoid signaling plays a key role in these hepatocarcinogenesis models. Citation Format: Yohei Shirakami, William S. Blaner, Masahito Shimizu, Hisataka Moriwaki, Mitsuru Seishima. Hepatic retinoid signaling in mouse hepatocarcinogenesis models. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 181. doi:10.1158/1538-7445.AM2013-181
Formation of Charcot-Leyden crystals by human basophils.
Authors: S J Ackerman, G J Weil, G J Gleich
Journal: The Journal of Experimental Medicine (1982)

Charcot-Leyden crystals (CLC) are currently believed to be unique to the eosinophil and a hallmark of active eosinophilic inflammation or proliferation. The distinctiveness of the CLC to the eosinophil was questioned in 1965 by Archer and Blackwood (9), but their demonstration of CLC formation in basophils was ignored and later dismissed (1) as being the result of eosinophil contamination of basophil-enriched cell suspensions. We reexamined this question and showed that basophils obtained from the peripheral blood of normal individuals form CLC and that basophils contain a protein that is immunochemically indistinguishable from eosinophil CLC protein. These conclusions are based upon the findings that (a) crystal formation in basophils was demonstrated by specific histochemical staining of crystal-containing cells in highly enriched basophil suspensions prepared by fluorescence-activated cell sorter (FACS) purification of surface IgE-positive cells, (b) that enrichment for surface IgE-positive cells (primarily basophils) by the FACS also enriched for cells staining positively by immunofluorescence for eosinophil CLC protein, and (c) that CLC protein was measured by radioimmunoassay in cell extracts prepared from purified basophil suspensions containing 97-99% basophils and absolutely no contaminating eosinophils. These basophil extracts contained a protein immunochemically indistinguishable from eosinophil CLC protein. Based upon these findings, the CLC or the protein comprising the crystal (lysophospholipase) can no longer be considered as distinctive to the eosinophil. We must now consider the possibility that the presence of CLC in tissues, sputum, or stool may also represent basophil involvement in disease processes.
Role of the granuloma in recurrent Crohn's disease.
Authors: R E Glass, W N Baker
Journal: Gut (1976)

The clinical significance of sarcoid-like granulomata in recurrent Crohn's disease has been investigated in 90 patients. The recurrence rate for non-granulomatous disease was double that of granulomatous disease. In granulomatous disease, involvement of the mesenteric lymph nodes did not affect the recurrence rate. This suggests that sarcoid-like granulomata reflect the patients' immune response and support the view that excision of the lymphatic drainage en bloc with affected bowel is not indicated.
Segregation Analysis of Pulmonary Function among Families in the Framingham Study
Authors: RACHEL J. GIVELBER, NAT N. COUROPMITREE, DANIEL J. GOTTLIEB, JANE C. EVANS, DANIEL LEVY, RICHARD H. MYERS, GEORGE T. O'CONNOR
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Familial aggregation of cross-sectional pulmonary function was examined in 5,003 subjects from 1,408 families participating in the Framingham Study. Subjects, who were members of either the Original Cohort (recruited from 1948 to 1952) or the Offspring Cohort (recruited from 1971 to 1974), underwent spirometry at a mean age of 53 yr. The effects of age, height, weight, and smoking status on FEV1 were evaluated through linear-regression analysis, with separate models for men and women in each cohort. The gender- and cohort-specific standardized residual FEV1 from these models was used as the phenotypic variable in familial correlation and segregation analyses to assess inheritance patterns. In models that assumed no major gene determining FEV1, correlation of pulmonary function was greater for mothers and offspring than for fathers and offspring ( ρ [mo] = 0.190, ρ [fo] = 0.112; p = 0.06), and sibling correlation exceeded parent–offspring correlation ( ρ [sib] = 0.225; p < 0.01). By comparison with a general model, in which transmission probabilities and residual familial correlations are arbitrary, models that imposed a Mendelian gene were rejected (p < 0.001). A model with no parent–offspring transmission of a major factor, but with residual familial correlation, provided as good a fit as the general model, suggesting that environmental and/or polygenic genetic influences determine FEV1.
Polypodium Fern Wreaths (Hagnaya)
Authors: Walter B. Shelley
Journal: JAMA (1985)

SOLVING the mystery of an unexplained dermatitis calls not only for informed curiosity on the part of the physician, but also for careful detective work on the part of a well-instructed patient. In this instance, the combination of these two avenues of inquiry led to an awareness of a new vector for skin disease. <h3>Report of a Case</h3> A 21-year-old man presented with a pruritic erythematous eruption of the volar forearms, lower parts of the legs, and eyelids, present with increasing severity for 12 days. It had appeared suddenly within hours of returning from vacation to his work in a wholesale florist supply shop. Severe pruritus had prevented him from working for the past six days. He had worked for six years in this shop, with only one prior attack of dermatitis occurring four months previously. The cause had remained unexplained and he had been treated successfully with intramuscular steroid
Changes in bone mineral density in patients with recent onset, active rheumatoid arthritis
Authors: M Guler-Yuksel, J Bijsterbosch, Y P M Goekoop-Ruiterman, J K de Vries-Bouwstra, H M J Hulsmans, W M de Beus, K H Han, F C Breedveld, B A C Dijkmans, C F Allaart, W F Lems
Journal: Annals of the Rheumatic Diseases (2007)

<h3>Objectives:</h3> We examined the effects of four different treatment strategies on bone mineral density (BMD) in patients with recently diagnosed, active rheumatoid arthritis (RA) and the influence of disease-related and demographic factors on BMD loss after 1 year of follow-up in the BeSt trial. <h3>Methods:</h3> BMD measurements of the lumbar spine and total hip were performed in 342 patients with recent onset RA at baseline and after 1 year. Multivariable regression analyses were performed to determine independent associations between disease and demographic parameters and BMD loss after 1 year. <h3>Results:</h3> Median BMD loss after 1 year was 0.8% and 1.0% of baseline in the spine and the hip, respectively. No significant differences between the treatment groups, including corticosteroids and the anti-tumour necrosis factor-α infliximab, were observed with regard to BMD loss after 1 year of treatment. Joint damage at baseline and joint damage progression according to the Sharp–van der Heijde score were independently associated with more BMD loss after 1 year. The use of bisphosphonates independently protected against BMD loss. <h3>Conclusions:</h3> After 1 year of follow-up in the BeSt study, we did not find differences in BMD loss between the four treatment strategies, including high doses of corticosteroids and anti-tumour necrosis factor-α. Joint damage and joint damage progression are associated with high BMD loss, which emphasises that BMD loss and erosive RA have common pathways in their pathogenesis.
Reply to Baiocchi et al.
Authors: J. Ichikawa, S. Tanabe
Journal: Endoscopy (2004)

We are grateful for the comments and discussion provided by Baiocchi et al. with regard to the treatment of type 1 gastric carcinoid tumors. Rappel et al. [1] and Soga [2] have reported metastasis in a few patients with gastric carcinoids associated with type A gastritis. Soga [2] also showed that the rate of metastasis is directly related to the size and depth of the tumors. On the basis of these reports, we believe that endoscopic mucosal resection (EMR) can be used to treat type 1 carcinoids associated with hypergastrinemia in patients who do not have more than three to five tumors measuring 1 cm or less at their widest diameter. After EMR, we carry out a histopathological assessment of the resected specimens and recommend additional surgery in patients who have invasion of the muscularis propria, vascular invasion, or residual tumor.
Association between voting patterns and mortality remains
Authors: G. D. Smith, D. Dorling
Journal: BMJ (1997)

Editor—We reported on the association between voting patterns and mortality in England and Wales during the 1983, 1987, and 1992 British general elections.1 There was a strong negative association between voting Conservative and mortality and a strong positive association between voting Labour and mortality; there was a weaker negative association between voting Liberal Democrat and mortality and a weaker positive association between abstention and mortality. The recent general election, in which a Labour government was elected with a large majority, has been interpreted as reflecting a breakdown of …
Drug Spotlight on Shock
Authors: GEORGE N. AAGAARD
Journal: Annals of Internal Medicine (1974)

Editorial Notes1 September 1974Drug Spotlight on ShockGEORGE N. AAGAARD, M.D.GEORGE N. AAGAARD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-3-399 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe management of shock is under the Drug Spotlight this quarter. Drugs play only a secondary role in this emergency, but, properly used, they may sustain life while efforts are made to correct the cause of shock, be it hemorrhage, trauma, anaplylaxis, extensive burns, or a severe infection. One or more of the following questions may be the focal point on which you may gather data as you study the management of shock in your hospital.1. Were efforts made to detect and correct, if present, hypovolemia, acidosis, electrolyte disturbance, or hypoxia?2. Was central venous pressure monitored as a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE N. AAGAARD, M.D.Affiliations: American Society for Clinical Pharmacology and Therapeutics Department of Medicine, School of Medicine University of Washington Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1974Volume 81, Issue 3Page: 399-399KeywordsBurnsDrugsHemorrhageHypoxiaShock ePublished: 1 December 2008 Issue Published: 1 September 1974 PDF downloadLoading ...
P Values Versus Means and Standard Errors In Reporting Data
Authors: James R. Boen
Journal: JAMA (1969)

<h3>To the Editor:—</h3> From my experience as a statistical consultant to research physicians, it appears that most (research physicians) consider the<i>P</i>value to be the main concept of statistics. Perhaps this is due to the semantic attractiveness of the phrases "statistical significance" and "statistical tests." "Significance" in medicine means something like "importance" while tests are the most objective procedures a physician performs. To many nonstatisticians the statement "My data are statistically significant" sounds like "If I took my data to a statistician he would agree with my conclusions." "Statistical significance," ironically, is merely a technical phrase to a statistician having little to do with importance or his total judgment; "tests" to a statistician are no more objective than anything else he does. As semantically attractive as are the aforementioned phrases about significance and tests, "estimation" has a very unscientific connotation to most nonstatisticians, suggesting off-hand guessing. In fact, the
The Diagnosis of Nonfunctioning Pheochromocytoma The Role of I-123 MIBG Imaging
Authors: SIMONE MAUREA, SECONDO LASTORIA, ALBERTO CUOCOLO, LUIGI CELENTANO, MARCO SALVATORE
Journal: Clinical Nuclear Medicine (1995)

A patient with an asymptomatic nonsecreting left adrenal pheochromocytoma concentrated I-123 MIBG. Iodine-123 MIBG scintigraphy showed abnormal uptake in the left adrenal bed. The authors conclude that I-123 MIBG imaging may allow the in vivo diagnosis of non-functioning pheochromocytomas when there is no clinical evidence of disease and other laboratory measurements are not helpful for tumor diagnosis.
Myocardial Clearance of Tc-99m Hexakis- Methoxy-2-Methylpropyl Isonitrile (MIBI) in Patients with Coronary Artery Disease
Authors: MAJA FRANCESCHI, JEAN GUIMOND, ROBERT E. ZIMMERMAN, MICHEL V. PICARD, ROBERT J. ENGLISH, PAULO A. CARVALHO, SABAH S. TUMEH, B LEONARD HOLMAN
Journal: Clinical Nuclear Medicine (1990)

Myocardial clearance of the new cationic, lypophilic myocardial perfusion agent, Tc-99m-hexakis-2-methoxy-2-methylpropyl isonitrile (MIBI) was studied in nine patients with coronary artery disease. Regional time-activity curves were determined from serial postexercise myocardial SPECT images after a single dose of Tc-99m MIBI. There were significant differences between the clearance rates from normal and ischemic myocardium. Tc-99m MIBI washout from normal myocardium was 27 +/- 8% by 6 hours after injection. Clearance from mild myocardial defects (initial activity greater than 60% of the activity in normal myocardium) was 16% by 6 hours in six patients. No washout was detected by 6 hours in the three patients with severe myocardial defects. The ratio between the activity in ischemic and normal myocardium increased from 0.70 +/- 0.08 to 0.80 +/- 0.13 and 0.84 +/- 0.13 at 4 and 6 hours after injection in the patients with mild defects. In the patients with large defects, the ratio increased from 0.42 +/- 0.09 to 0.54 +/- 0.07 at 6 hours. It is concluded that, while redistribution is substantially slower than with Tl-201, image interpretation and data evaluation should be approached cautiously when imaging is delayed 4 hours or more after injection of Tc-99m MIBI. Quantitative techniques aimed at evaluating the extent and intensity of myocardial ischemia will be particularly affected.