Leukopenia, Bone Pain, and Bone Necrosis in Patients with Acute Leukemia
Authors: BOYD A. NIES
Journal: Annals of Internal Medicine (1965)

Article1 April 1965Leukopenia, Bone Pain, and Bone Necrosis in Patients with Acute LeukemiaA Clinicopathologic ComplexBOYD A. NIES, M.D., DONALD W. KUNDEL, M.D., LOUIS B. THOMAS, M.D., EMIL J FREIREICH, M.D.BOYD A. NIES, M.D., DONALD W. KUNDEL, M.D., LOUIS B. THOMAS, M.D., EMIL J FREIREICH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-698 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral recent studies have demonstrated the occurrence of bone necrosis in acute leukemia (1-4). Kundel, Brecher, Bodey, and Brittin (1) recently have studied a group of patients with acute lymphocytic leukemia and increased bone marrow reticulin, in which six patients were also found to have bone and marrow necrosis. Their results suggested that the clinical course of this group was characterized by bone pain, long periods of leukopenia, and poor response to therapy. Bone necrosis was found to occur much more frequently in acute lymphocytic leukemia than in acute myelogenous leukemia.In order to determine if the above suggested features...References1. KUNDELBRECHERBODEYBRITTIN DWGGPGM: Reticulin fibrosis and bone infarction in acute leukemia: Implications for prognosis. Blood 23: 526, 1964. CrossrefMedlineGoogle Scholar2. THOMASFORKNERFREIBESSESTABENAU LBCEEBEJR: The skeletal lesions of acute leukemia. Cancer 14: 608, 1961. CrossrefMedlineGoogle Scholar3. GRIFFITHS DL: Bone changes in blood diseases in Modern Trends in Blood Diseases, edited by WILKINSON, J. F., Butterworth and Co., Ltd., London, 1955, p. 1. Google Scholar4. HASHIMOTOYUMOTOHAMADAKIKUCHI MTTM: Bone marrow in acute leukemia. Kyushu J. Med. Sci. 12: 197, 1961. MedlineGoogle Scholar5. BISEL HF: Criteria for the evaluation of response to treatment in acute leukemia. Blood 11: 676, 1956. Google Scholar6. MCFARLANDDAMESHEK CWW: Biopsy of bone marrow with the Vim-Silverman needle. JAMA 166: 1464, 1958. CrossrefMedlineGoogle Scholar7. CONRADCROSBY MEWH: Bone marrow biopsy: modification of the Vim-Silverman needle. J. Lab. Clin. Med. 57: 642, 1961. Google Scholar8. FREIREICHGEHANSULMANBOGGSFREI EJEADDRE: The effect of chemotherapy on acute leukemia in the human. J. Chronic Dis. 14: 593, 1961. CrossrefMedlineGoogle Scholar9. SILVERSTEINKELLY MNPJ: Leukemia with osteoarticular symptoms and signs. Ann. Intern. Med. 59: 637, 1963. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BOYD A. NIES, M.D.; DONALD W. KUNDEL, M.D.; LOUIS B. THOMAS, M.D.; EMIL J FREIREICH, M.D.Affiliations: Bethesda, MarylandFrom the National Cancer Institute and the Clinical Center, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. 20014.Requests for reprints should be addressed to Emil J Freireich, M.D., Leukemia Service, Medicine Branch, National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. 20014. 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