Ranitidine-Induced Granulocytopenia: Recurrence with Cimetidine Administration
Authors: ALAN F. LIST
Journal: Annals of Internal Medicine (1988)

Brief Reports1 April 1988Ranitidine-Induced Granulocytopenia: Recurrence with Cimetidine AdministrationALAN F. LIST, M.D., DAVID H. BEAIRD, M.D., THOMAS KUMMET, M.D.ALAN F. LIST, M.D.Search for more papers by this author, DAVID H. BEAIRD, M.D.Search for more papers by this author, THOMAS KUMMET, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-566 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDrug-induced granulocytopenia occurs infrequently with Cimetidine administration (1). Ranitidine hydrochloride, the newest H2-antagonist in use, has gained widespread application because of its longer dosing interval and relative lack of serious adverse reactions (2). We report a case of reversible, ranitidine-induced granulocytopenia with bone marrow findings simulating those of acute promyelocytic leukemia that recurred after Cimetidine was administered.A 61-year-old white man was hospitalized with fever and granulocytopenia on 10 October 1986. Five months earlier a craniotomy was done with partial resection of a grade IV astrocytoma. Postoperatively, the patient received 5000 rad wholebrain irradiation and phenytoin therapy, 300 mg daily,...References1. MCGUIGAN J. A consideration of the adverse effects of Cimetidine. Gastroenterology. 1981;80:81-92. CrossrefGoogle Scholar2. ZELDIS J, FREIDMAN L, and ISSELBACHER J. Ranitidine: a new H2-receptor antagonist. N Engl J Med. 1983;309:1368-73. CrossrefMedlineGoogle Scholar3. HERRERA A, SOLAL-CELIGNY P, DRESCH C, VALLIN J, and BERNADES P. Ranitidine [Letter]. N Engl J Med. 1984;310:1604-5. Google Scholar4. SHIELDS L, FILES J, DOLL D, and GREENBERG B. Ranitidine and agranulocytosis [Letter]. Ann Intern Med. 1986; 104:128. LinkGoogle Scholar5. FELDMAN E and ISENBERG J. Effects of metiamide on gastric acid hypersecretion, steatorrhea and bone marrow function in a patient with systemic mastocytosis. N Engl J Med. 1976;295:1178-9. CrossrefMedlineGoogle Scholar6. FLEISCHER D and SAMLOFF I. Cimetidine therapy in a patient with metiamide-induced agranulocytosis [Letter]. N Engl J Med. 1977;296:342. CrossrefMedlineGoogle Scholar7. GESPACH C and ABITA J. Human polymorphonuclear neutrophils: pharmacological characterization of histamine receptors mediating the elevation of cyclic-AMP. Mol Pharmacol. 1982;21:78-85. MedlineGoogle Scholar8. SAWUTZ D, KALINYAK K, WHITSETT J, and JOHNSON C. Histamine H2 receptor desensitization in HL-60 human promyelocyte leukemia cells. J Pharmacol Exp Ther. 1984;231:1-7. MedlineGoogle Scholar9. GROSS S and WORTHINGTON-WHITE D. Cimetidine suppression of CFU-C in males. Am J Hematol. 1984;17:279-86. CrossrefMedlineGoogle Scholar10. SAZIE E and JAFFE J. Severe granulocytopenia with Cimetidine and Phenytoin [Letter]. Ann Intern Med. 1980;93:151-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALAN F. LIST, M.D.; DAVID H. BEAIRD, M.D.; THOMAS KUMMET, M.D.Affiliations: Phoenix Veterans Administration Medical Center and Good Samaritan Medical Center Phoenix, Arizona PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistamine receptor 2 blockade selectively impacts B and T cells in healthy subjectsRanitidine Inhibition of Breast Tumor Growth Is B Cell Dependent and Associated With an Enhanced Antitumor Antibody ResponseRanitidine modifies myeloid cell populations and inhibits breast tumor development and spread in miceThe impact of ranitidine on monocyte responses in the context of solid tumorsAgranulocytosis Associated with Initiation of Famotidine TherapyIs Clozapine Safe in the Elderly?Ranitidine-induced photosensitivityRanitidine-associated autoimmune hemolytic anemia in a health maintenance organization populationThe growth capacity of hematopoietic progenitor cells in severe neutropenia induced by famotidineChemical Agents Which Suppress Myelopoiesis: Agranulocytosis and LeukemiaSafety profile of long-term H2-antagonist therapyCimetidine induced pancytopeniaGastrointestinal drugsMechanism of Ranitidine Associated AnemiaReversible Hematologic Suppression during Ranitidine TreatmentAgranulocytosis after ranitidine administrationHaematological Adverse Effects of Histamine H2-Receptor Antagonists 1 April 1988Volume 108, Issue 4Page: 566-567KeywordsAdverse reactionsBone marrowDrug administrationDrugsFeversGlioblastoma multiformeHematology and oncology ePublished: 1 December 2008 Issue Published: 1 April 1988 PDF downloadLoading ...