Monoamine-oxidase Inhibitor Reactions Simulating Phenochromocytoma Attacks
Authors: HERBERT F. R. PLASS
Journal: Annals of Internal Medicine (1964)

Case Studies1 November 1964Monoamine-oxidase Inhibitor Reactions Simulating Phenochromocytoma AttacksHERBERT F. R. PLASS, M.D.HERBERT F. R. PLASS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-924 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMonoamine-oxidase (MAO) inhibitors have been increasingly prescribed for depression since 1959. Informal estimates state that under current practices 40% of hospitalized psychiatric patients receive them at some time. Many ambulatory patients receive them as well, perhaps a greater total number than patients in institutions. Adverse reactions must be uncommon in view of the great number of treated patients, yet there have been many reports of severe reactions recently.Tranylcypromine (Parnate®) was recommended about 1960 in the U. S. A. as the most useful of these drugs (1). This compound resembles the sympathomimetic amines in chemical structure. Its ability to potentiate...References1. SCHIELEBENSON BCWM: Anti-depressive medications. a guide for the general physician. Postgrad. Med. 28: 101, 1960. CrossrefMedlineGoogle Scholar2. SPENCERSMITH GTSE: Dangers of monoamine oxidase inhibition. Brit. Med. J. 5332: 750, 1962. Google Scholar3. LONDONMILNE DRMD: Dangers of monoamine oxidase inhibitors. Brit. Med. J. 5321: 1752, 1962. CrossrefGoogle Scholar4. VAN ROSSUM JM: Potential danger of monoamine oxidase inhibitors and alpha methyldopa. Lancet 1: 950, 1963. CrossrefMedlineGoogle Scholar5. CLARK JA: Side effects of tranylcypromine. Lancet 1: 618, 1961. CrossrefGoogle Scholar6. LURIESALZER MLHM: Tranylcypromine (Parnate) in the ambulatory treatment of depressed patients. Amer. J. Psychiat. 118: 152, 1961. CrossrefMedlineGoogle Scholar7. BLACKWELL B: Tranylcypromine. Lancet 1: 167, 1963. Google Scholar8. BLACKWELL B: Tranylcypromine. Lancet 2: 414, 1963. CrossrefGoogle Scholar9. SOLLMAN TA: Manual of Pharmacology, W. B. Saunders Co. Philadelphia, 1957. Google Scholar10. BLACKWELL B: Hypertensive crisis due to monamine oxidase inhibitors. Lancet 2: 849, 1963. CrossrefMedlineGoogle Scholar11. ASATOORLEVIMILNE AMAJMD: Letters to editor. Lancet 2: 733, 1963. CrossrefMedlineGoogle Scholar12. VAN SLYKEHART LLEB: Presence of tyramine in cheddar cheese. Amer. Chem. J. 30: 8, 1903. Google Scholar13. TAYLOR DC: Alarming reaction to pethidine in patients on phenelzine. Lancet 2: 401, 1962. CrossrefGoogle Scholar14. COHEN RA (MODERATOR): Clinical Staff Conference (NIH). The Metabolism of the catecholamines (clinical implications). Ann. Intern. Med. 56: 960, 1962. LinkGoogle Scholar15. SCHAYER RW: Increase of tyramine elimination after administered tyramine, by treatment with monoamine-oxidase inhibitors. Proc. Soc. Exp. Biol. Med. 84: 60, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the Department of Internal Medicine, University of Minnesota Medical School, Minneapolis, Minn.Requests for reprints should be addressed to Herbert F. R. Plass, M.D., 1935 Medical Arts Bldg., Minneapolis, Minn. 55402. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAdverse Drug Reactions in Patients with Phaeochromocytoma 1 November 1964Volume 61, Issue 5_Part_1Page: 924-927KeywordsAdverse reactionsDrugsHypertension Issue Published: 1 November 1964 PDF DownloadLoading ...