The Standardization of Desiccated Thyroid
Authors: N. R. STEPHENSON
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 July 1967The Standardization of Desiccated ThyroidN. R. STEPHENSON, PH.D.N. R. STEPHENSON, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-211 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAccording to USP XVII, desiccated thyroid must contain not less than 0.17 and not more than 0.23% iodine in thyroid combination and must be "free from iodine in inorganic or any form of combination other than that peculiar to the thyroid gland." The source of the material is not specified, but it is described as being obtained "from domesticated animals that are used for food by man." However, Stasilli and Kroc (1) reported that porcine thyroid preparations had significantly more goiter prevention activity than those prepared from a bovine source. This observation, confirmed by Wiberg and associates (2), drew attention...References1. STASILLIKROC NRRL: Biologic activity of pork and beef thyroid preparations. J. Clin. Endocr. 16: 1595, 1956. CrossrefGoogle Scholar2. WIBERGDEVLINSTEPHENSONCARTERBAYNE GSWFNRJRAJ: A comparison of the thyroxine: tri-iodothyronine content and biological activity of thyroid from various species. J. Pharm. Pharmacol. 14: 777, 1962. CrossrefMedlineGoogle Scholar3. LEMIEUXTALMAGE RJM: The determination of liothyronine and thyroxine in thyroid preparations. J. Pharm. Pharmacol. 18: 94, 1966. CrossrefMedlineGoogle Scholar4. WILLIAMSMEISTERFLORSHEIM ADLWH: Chemical identification of defective thyroid preparations. J. Pharm. Sci. 52: 833, 1963. CrossrefMedlineGoogle Scholar5. KOLOGLUSCHWARTZCARTER SHLAC: Quantitative determination of the thyroxine, triiodothyronine, monoiodotyrosine and diiodotyrosine content of desiccated thyroid. Endocrinology 78: 231, 1966. CrossrefMedlineGoogle Scholar6. DEVLINWATANABE WFH: Thyroxin-triiodothyronine concentrations in thyroid powders. J. Pharm. Sci. 55: 390, 1966. CrossrefMedlineGoogle Scholar7. DEVLINSTEPHENSON WFNR: The chemical determination of liothyronine and thyroxine in enzymic hydrolysates of pork thyroid. J. Pharm. Pharmacol. 14: 597, 1962. CrossrefMedlineGoogle Scholar8. PILEGGIGOLUBLEE VJOJND: Determination of thyroxine and triiodothyronine in commercial preparations of desiccated thyroid and thyroid extract. J. Clin. Endocr. 25: 949, 1965. CrossrefGoogle Scholar9. SOFIANIDESMELONIALGERCANARY TCREJJ: Separation and quantitative recovery of iodinated amino acids and iodide by thin layer chromatography. Proc. Soc. Exp. Biol. Med. 123: 646, 1966. CrossrefMedlineGoogle Scholar10. MACGREGOR AG: Why does anybody use thyroid B.P.? Lancet 1: 329, 1961. CrossrefMedlineGoogle Scholar11. CATZGINSBURGSALENGER BES: Clinically inactive thyroid U.S.P. A preliminary report. New Eng. J. Med. 266: 136, 1962. CrossrefMedlineGoogle Scholar12. WILLIAMSMEISTERFAIRCLOTHFLORSHEIM ADLMWH: Significance of phosphorus-nitrogen ratio in U.S.P. thyroid. J. Pharm. Sci. 53: 1415, 1964. CrossrefMedlineGoogle Scholar13. WOOLSELENKOW MSHA: Physiologic combinations of synthetic thyroid hormones in myxedema. Clin. Pharmacol. Ther. 6: 710, 1965. CrossrefMedlineGoogle Scholar14. SELENKOWWOOL HAMS: A new synthetic thyroid hormone combination for clinical therapy. Ann. Intern. Med. 67: 89, 1967. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of National Health and Welfare Ottawa, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLiothyronine and Desiccated Thyroid Extract in the Treatment of HypothyroidismHistorical and Current Perspective in the Use of Thyroid Extracts for the Treatment of HypothyroidismComparative clinical pharmacology of thyroid hormones 1 July 1967Volume 67, Issue 1Page: 211-212KeywordsFoodThyroidUnited States pharmacopeia Issue Published: 1 July 1967 PDF DownloadLoading ...