tbuckley/cabot-search huggingface dataset:
Pure Red-Cell Aplasia of 10 Years' Duration Due to Persistent Parvovirus B19 Infection and Its Cure with Immunoglobulin Therapy
Authors: Gary Kurtzman, Norbert Frickhofen, Janice Kimball, Douglas W. Jenkins, Arthur W. Nienhuis, Neal S. Young
Journal: New England Journal of Medicine (1989)

PARVOVIRUS B19 is the etiologic agent of transient aplastic crisis, an acute episode of bone marrow failure in persons with underlying hemolysis.1 , 2 In tissue-culture studies, parvovirus B19 infects3 and replicates4 in erythroid progenitor cells. The pathophysiologic basis of acute marrow failure in patients is viral tropism and cytotoxicity for erythroid progenitor cells.5 , 6 In experimental7 and natural8 infections, the infection is terminated with the development of specific antibodies, which neutralize the activity of the virus in vitro.9 In the immunocompromised host who is unable to produce neutralizing antibody,10 an infection with parvovirus B19 can persist and cause chronic bone marrow failure, . . .
Does Juvenile Temporal Arteritis Exist?-Reply
Authors: J. T. Lie
Journal: JAMA (1976)

If by arteritis is meant inflammation of an artery , 1 then it is correct, semantically, to refer to any form of inflammation of the temporal artery as temporal arteritis . The condition first described by us was an inflammatory lesion of the temporal arteries, though it differed from the classic temporal arteritis (more correctly, granulomatous giant cell arteritis of the temporal artery occurring almost exclusively in the aged) both clinically and histopathologically. The qualifying word  was used in our communication to avoid confusion with the well known entity of (granulomatous giant cell) temporal arteritis (of the aged), since our four patients were two young adults and two children. To us, juvenile temporal arteritis does not mean the occurrence of the classic (granulomatous giant cell) temporal arteritis occurring in young adults or children, but quite a separate and distinct clinicopathologic entity. Should the peculiar inflammatory lesion of the temporal
Abstract 4888: The effect of chromatin structure in regulation of telomere length in telomerase negative ALT cells
Authors: A Ra Jung, Hye Ryun Kim, Bong-Kyeong Oh, Hei-Cheul Jeung, Hyun Cheol Chung, Sun Young Rha
Journal: Cancer Research (2010)

Abstract Telomeres are DNA-protein complexes at the ends of linear eukaryotic chromosomes and composed of tandem repeats of a TTAGGG sequence ending in a 3′ single-stranded overhang, or the G-strand overhang. And telomeres confer chromosomal stability protecting chromosome ends. Most immortalized human cell lines maintain and extend their telomere by activating telomerase. A small number of cells maintain and extend their telomere lengths without telomerase by homologous recombination of telomeres and this mechanism is called as alternative lengthening of telomere (ALT). There are many factors involved in telomere regulation. Recently, it has been known that chromatin structure is closely related to regulation of telomere length. Maintaining telomere length is important process in tumorigenesis and it has been suggested that telomeres are important target for cancer therapy. However, in ALT cells the effect of chromatin structure on regulation of telomere length is not understood. In this study, we induced change of chromatin structure by treating Trichostatin A (TSA), Histone deacetylase inhibitor, in ALT cells. Then, we measured APBs (ALT associated PML bodies) patterns, T-SCE (Telomere Sister Chromatid Exchange) frequency and telomere lengths. APBs patterns were analyzed by FISH (Fluorescence in situ hybridization) combined IF (Immunofluorescence staining). We compared the number of APBs in ALT cells with or without TSA. In GM 847 (ALT cell), APBs positive cells were found to be more frequent in GM 847 with TSA (63/100) compared to GM 847 without TSA (30/100) (p&amp;lt;0.001). A similar result was found in other ALT cell line, WI38-VA13. APB positive cells were more frequent in WI38-VA13 with TSA (38/100) compare to WI38-VA13 without TSA (18/100), (p&amp;lt;0.001). T-SCE frequency was determined by CO-FISH (Chromosome Orientation-FISH). Increse of T-SCE frequency was found in GM 847 with TSA (262/1026, 25.5%) compared to GM 847 without TSA (215/1026, 20.9%), (p&amp;lt;0.001). Telomere length was determined by telomere-FISH. Decrease of telomere length was found in GM 847 with TSA (telomere intensity mean 25.11%) compared to GM 847 without TSA (telomere intensity mean 29.8%), (p&amp;lt;0.001). This study demonstrated a close association between chromatin structure and telomere recombination in ALT cells and this result might provide insight into the mechanism of regulation of telomere length in telomerase-negative cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4888.
Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids
Authors: Claudio J. Villanueva, Mara Monetti, Michelle Shih, Ping Zhou, Steve M. Watkins, Sanjay Bhanot, Robert V. Farese
Journal: Hepatology (2009)

Nonalcoholic fatty liver disease, characterized by the accumulation of triacylglycerols (TGs) and other lipids in the liver, often accompanies obesity and is a risk factor for nonalcoholic steatohepatitis and fibrosis. To treat or prevent fatty liver, a thorough understanding of hepatic fatty acid and TG metabolism is crucial. To investigate the role of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), a key enzyme of TG synthesis, in fatty liver development, we studied mice with global and liver-specific knockout of Dgat1. DGAT1 was required for hepatic steatosis induced by a high-fat diet and prolonged fasting, which are both characterized by delivery of exogenous fatty acids to the liver. Studies in primary hepatocytes showed that DGAT1 deficiency protected against hepatic steatosis by reducing synthesis and increasing the oxidation of fatty acids. In contrast, lipodystrophy (aP2-SREBP-1c436) and liver X receptor activation (T0901317), which increase de novo fatty acid synthesis in liver, caused steatosis independently of DGAT1. Pharmacologic inhibition of Dgat1 with antisense oligonucleotides protected against fatty liver induced by a high-fat diet. Conclusion: Our findings identify a specific role for hepatic DGAT1 in esterification of exogenous fatty acids and indicate that DGAT1 contributes to hepatic steatosis induced by this mechanism. (HEPATOLOGY 2009.)
Mortality in workers exposed to electromagnetic fields.
Authors: S Milham
Journal: Environmental Health Perspectives (1985)

In an occupational mortality analysis of 486,000 adult male death records filed in Washington State in the years 1950-1982, leukemia and the non-Hodgkin's lymphomas show increased proportionate mortality ratios (PMRs) in workers employed in occupations with intuitive exposures to electromagnetic fields. Nine occupations of 219 were considered to have electric or magnetic field exposures. These were: electrical and electronic technicians, radio and telegraph operators, radio and television repairmen, telephone and power linemen, power station operators, welders, aluminum reduction workers, motion picture projectionists and electricians. There were 12,714 total deaths in these occupations. Eight of the nine occupations had PMR increases for leukemia [International Classification of Diseases (ICD), seventh revision 204] and seven of the nine occupations had PMR increases for the other lymphoma category (7th ICD 200.2, 202). The highest PMRs were seen for acute leukemia: (67 deaths observed, 41 deaths expected; PMR 162), and in the other lymphomas (51 deaths observed, 31 deaths expected; PMR 164). No increase in mortality was seen for Hodgkin's disease or multiple myeloma. These findings offer some support for the hypothesis that electric and magnetic fields may be carcinogenic.
Transfemoral plug closure of patent ductus arteriosus. Experiences in 61 consecutive cases treated without thoracotomy.
Authors: K Sato, M Fujino, T Kozuka, Y Naito, S Kitamura, S Nakano, C Ohyama, Y Kawashima
Journal: Circulation (1975)

We successfully closed the isolated patent ductus arteriosus in 58 of 61 consecutive patients using the transfemoral-catheter method originally introduced by Porstmann in 1968. To perform this technique more safely and reliably, some instrumental and technical improvements were made. The indications for this method have been expanded to include the cylindrical or window-type ductus as well as the conical-shaped ductus. Classification into three groups of the configuration of the ductus by angiography has been useful in selecting the shape of the closing plug. Whenever feasible, we consider the catheter technique to be the method of choice to close the ductus.
MicroRNA Regulates the Expression of Human Cytochrome P450 1B1
Authors: Yuki Tsuchiya, Miki Nakajima, Shingo Takagi, Takao Taniya, Tsuyoshi Yokoi
Journal: Cancer Research (2006)

Abstract MicroRNAs (miRNA) are small noncoding RNAs that regulate gene expression through translational repression or mRNA cleavage. Here, we found that cytochrome P450 (CYP), a superfamily of drug-metabolizing enzymes, is a target of miRNA. Human CYP1B1, which is highly expressed in estrogen target tissues, catalyzes the metabolic activation of various procarcinogens and the 4-hydroxylation of 17β-estradiol. CYP1B1 protein is abundant in cancerous tissues. We identified a near-perfect matching sequence with miR-27b in the 3′-untranslated region of human CYP1B1. Luciferase assays revealed that the reporter activity of the plasmid containing the miR-27b recognition element was decreased in MCF-7 cells (miR-27 positive) but not in Jurkat cells (miR-27b negative). Exogenously expressed miR-27b could decrease the luciferase activity in Jurkat cells. In MCF-7 cells, the antisense oligoribonucleotide for miR-27b restored the luciferase activity and increased the protein level and enzymatic activity of endogenous CYP1B1. These results suggested that human CYP1B1 is post-transcriptionally regulated by miR-27b. The expression levels of miR-27b and CYP1B1 protein in breast cancerous and adjacent noncancerous tissues from 24 patients were evaluated. In most patients, the expression level of miR-27b was decreased in cancerous tissues, accompanied by a high level of CYP1B1 protein. A significant inverse association was observed between the expression levels of miR-27b and CYP1B1 protein. Thus, the decreased expression of miR-27b would be one of causes of the high expression of CYP1B1 protein in cancerous tissues. This is the first study to show that miRNAs regulate not only essential genes for physiologic events but also drug-metabolizing enzymes. (Cancer Res 2006; 66(18): 9090-8)
Exposure and Effect Assessment of Aerosolized Red Tide Toxins (Brevetoxins) and Asthma
Authors: Lora E. Fleming, Judy A. Bean, Barbara Kirkpatrick, Yung Sung Cheng, Richard Pierce, Jerome Naar, Kate Nierenberg, Lorraine C. Backer, Adam Wanner, Andrew Reich, Yue Zhou, Sharon Watkins, Mike Henry, Julia Zaias, William M. Abraham, Janet Benson, Amy Cassedy, Julie Hollenbeck, Gary Kirkpatrick, Tainya Clarke, Daniel G Baden
Journal: Environmental Health Perspectives (2009)

In previous studies we demonstrated statistically significant changes in reported symptoms for lifeguards, general beach goers, and persons with asthma, as well as statistically significant changes in pulmonary function tests (PFTs) in asthmatics, after exposure to brevetoxins in Florida red tide (Karenia brevis bloom) aerosols.In this study we explored the use of different methods of intensive ambient and personal air monitoring to characterize these exposures to predict self-reported health effects in our asthmatic study population.We evaluated health effects in 87 subjects with asthma before and after 1 hr of exposure to Florida red tide aerosols and assessed for aerosolized brevetoxin exposure using personal and ambient samplers.After only 1 hr of exposure to Florida red tide aerosols containing brevetoxin concentrations > 57 ng/m(3), asthmatics had statistically significant increases in self-reported respiratory symptoms and total symptom scores. However, we did not see the expected corresponding changes in PFT results. Significant increases in self-reported symptoms were also observed for those not using asthma medication and those living >/= 1 mile from the coast.These results provide additional evidence of health effects in asthmatics from ambient exposure to aerosols containing very low concentrations of brevetoxins, possibly at the lower threshold for inducing a biologic response (i.e., toxicity). Consistent with the literature describing self-reported symptoms as an accurate measure of asthmatic distress, our results suggest that self-reported symptoms are a valuable measure of the extent of health effects from exposure to aerosolized brevetoxins in asthmatic populations.
A STUDY OF CANCER IMMUNITY BY THE METHOD OF CULTIVATING TISSUES OUTSIDE THE BODY
Authors: Robert A. Lambert, Frederic M. Hanes
Journal: The Journal of Experimental Medicine (1911)

1. Sarcoma cultivated in plasma from immune animals grows quite as vigorously as in plasma from normal and tumor-bearing animals, thus affording further proof of the absence of specific cytolytic substances in the body fluids of animals immune to transplantable cancer. 2. Animals may be successfully inoculated with sarcoma cultivated in vitro, although, in the case of rat sarcoma, there is evidence of diminished virulence. 3. Subcultures of sarcoma cultivated in vitro may be made by transferring to fresh plasma the original piece of tissue, or a portion of the outgrowth. The duration of life of sarcoma cells under these conditions seems dependent only on a renewal of the medium.
PRACTICAL CONSIDERATIONS IN THE MANAGEMENT OF MALIGNANT BONE TUMORS
Authors: H. R. McCarroll
Journal: JAMA (1953)

No single problem in the field of orthopedic surgery has been more bewildering than the diagnosis and treatment of malignant bone tumor. This situation has resulted from confusion in the classification of bone neoplasms and from the often hopeless attitude expressed regarding cure. Accurate classification of bone tumors is impossible from a purely clinical standpoint, and the aid of an excellent bone pathologist must be sought in order to properly evaluate each individual case. The confusion has been further increased by the fact that these tumors represent one of the most difficult problems with which the pathologist must cope. Primary malignant bone tumors are rare, and few pathologists can qualify as experts in the field. This results in many mistaken diagnoses, which, in turn, have often resulted in the administration of erroneous definitive therapy. Treatment cannot be intelligently planned or recommended unless an accurate diagnosis is available. How then should
Letter: Cancer--attack or retreat?
Authors: J. E. McShulskis
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
928 ELEVATED ADIPONECTIN SERUM LEVELS IN PATIENTS WITH CHRONIC ALCOHOL ABUSE RAPIDLY DECREASE DURING ALCOHOL WITHDRAWAL
Authors: C. Buechler, A. Schaeffler, C. Dorn, M. Johann, M. Neumeier, P. Koehl, T.S. Weiss, N. Wodarz, P. Kiefer, C. Hellerbrand
Journal: Journal of Hepatology (2008)
Effects of reperfusion and superoxide dismutase on myocardial infarct size in a closed chest pig model
Authors: U. Naslund, S. Haggmark, G. Johansson, K. Pennert, S. Reiz, S. L Marklund
Journal: Cardiovascular Research (1992)

Journal Article Effects of reperfusion and superoxide dismutase on myocardial infarct size in a closed chest pig model Get access Ulf Näslund, Ulf Näslund Corresponce to Dr Näslund. Search for other works by this author on: Oxford Academic PubMed Google Scholar Sören Häggmark, Sören Häggmark Search for other works by this author on: Oxford Academic PubMed Google Scholar Göran Johansson, Göran Johansson Search for other works by this author on: Oxford Academic PubMed Google Scholar Kjell Pennert, Kjell Pennert Search for other works by this author on: Oxford Academic PubMed Google Scholar Sebastian Reiz, Sebastian Reiz Search for other works by this author on: Oxford Academic PubMed Google Scholar Stefan L Marklund Stefan L Marklund Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 2, February 1992, Pages 170–178, https://doi.org/10.1093/cvr/26.2.170 Published: 01 February 1992 Article history Received: 24 April 1991 Accepted: 07 October 1991 Published: 01 February 1992
A WORKING CLASSIFICATION OF THE CAUSES OF STERILITY
Authors: SAMUEL R. MEAKER
Journal: JAMA (1928)

During the last fourteen years there have been three noteworthy advances in the field of sterility: postcoital examination, a better comprehension of metabolic factors, and the Rubin test of tubal patency. The result is first of all an increased knowledge of etiology, and in consequence more accurate diagnosis and more successful treatment.  The outline herewith presented sets forth the causes of sterility as they are understood today in the light of this recent progress. There are six major requisites of fertility; since each of them may fail of fulfilment in numerous details, the causes of sterility fall naturally into six main groups.  I have entitled this paper a working classification of the causes of sterility because it may be turned to practical use in two ways. First, a complete listing of possible causes insures that nothing will be overlooked in the investigation of cases. My associates and I have developed
Measles Immunization of 2-Year-Olds in a Rural Southern State
Authors: Sandor Feldman
Journal: JAMA (1994)

To assess the measles vaccine coverage of 2-year-old children living in Mississippi during the national measles epidemic of 1989 and 1990.Survey of 2-year-olds randomly selected from the 1987 birth cohort. The status of measles-mumps-rubella (MMR) vaccination was determined by medical record reviews and family contacts.A predominantly rural state in the southeastern United States with a large black minority population (35%) and a low per capital income ($9827 to $12,899). Approximately 80% of MMR immunizations are given by public health service nurses working in nine health districts.A total of 2450 preschool-aged children representing 6% of the 1987 birth cohort (n = 41,279). Three hundred forty-one children were considered ineligible, leaving 2109 in the final sample.Confirmed vaccination by the age of 2 years. Rates of immunization were calculated for the entire state, its health districts, and subgroups based on population density, per capita income, type of clinic visited, and race.The statewide immunization rate was 87% (95% confidence interval, 86% to 88%). Among the nine health districts, rates varied from 79% to 97% (median, 88%). They were similar for white and black children in each health district and within the state as a whole. The level of vaccine coverage was significantly higher in districts with lower population densities (89% vs 85%, P = .02) and in those with higher per capita incomes (89% vs 86%, P = .03). There were four minor outbreaks of measles during 1989 and 1990; half of the cases occurred in unimmunized children too young to receive the MMR vaccine.A high rate of measles immunization is attainable among 2-year-olds living in a rural state with a large black minority population and limited economic resources.
Geographical analysis of cardiovascular mortality: a cautionary note
Authors: S J Pocock, A G Shaper
Journal: BMJ (1980)

are exceptionally difficult to make from geographical data.3(3) Furthermore, the analysis of data for towns need not provide any useful guide to the results obtained by analysing the same data at the individual level.The aggregation of data for individuals into towns creates all manner of spurious geographical associations, which statistical techniques are very adept at identifying.(4) Statistical analysis of geographical data suffers from a number of problems that have been completely ignored.In this respect the study
Fusion Protein Identified In Childhood Leukemia
Authors: J. Glover
Journal: JNCI Journal of the National Cancer Institute (1990)

Fusion Protein Identified In Childhood Leukemia Get access Janet Glover Janet Glover Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 16, 15 August 1990, Pages 1316–1317, https://doi.org/10.1093/jnci/82.16.1316 Published: 15 August 1990
Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: a multicenter, randomized, controlled trial from the SFGM-TC and GFLLC
Authors: Laurent Sutton, Sylvie Chevret, Olivier Tournilhac, Marine Diviné, Véronique Leblond, Bernadette Corront, Stéphane Leprêtre, Houchingue Eghbali, Eric Van Den Neste, Mauricette Michallet, Frédéric Maloisel, Krimo Bouabdallah, Didier Decaudin, Christian Berthou, Pauline Brice, Hugo Gonzalez, Elise Chapiro, Isabelle Radford-Weiss, Nathalie Leporrier, Karim Maloum, Florence Nguyen-Khac, Frédéric Davi, Julie Lejeune, Hélène Merle-Béral, Michel Leporrier
Journal: Blood (2011)