tbuckley/cabot-search huggingface dataset:
Esophageal tumor diagnosed by capsule endoscopy
Authors: A. Sánchez-Yagüe, A. Caunedo-Álvarez, R. Romero-Castro, J. Romero-Vázquez, A. Antúnez-Infante, F. Pellicer-Bautista, J. Herrerías-Gutiérrez
Journal: Endoscopy (2006)

A 74-year-old man was referred to our unit with a 3-year history of typical heartburn symptoms. His heartburn had became refractory to treatment with proton pump inhibitors in the 3 weeks prior to presentation but it was not accompanied by dysphagia, anemia, hematemesis, or weight loss. He was recommended to have an upper gastrointestinal endoscopy but he refused to undergo this examination. After much discussion, he was offered the option of esophageal capsule endoscopy, with the proviso that if any abnormal finding was observed he would require standard upper gastrointestinal endoscopy. The patient swallowed the video capsule (PillCam ESO; Given Imaging, Yoqneam, Israel) without problems and the study lasted for 20 minutes and 23 seconds, during which time the capsule did not pass into stomach (although capsule excretion was confirmed later). The capsule study revealed a polypoid lesion in the mid-esophagus (Figure [1], Video 1), as well as mucosa distal to the polyp that resembled gastric mucosa and was consistent with a diagnosis of Barrett’s esophagus.
Expression of the l-fucose moiety on epidermal keratinocytes in psoriasis induced by the Koebner phenomenon: a sequential study
Authors: MADALENE C. Y. HENG, SIANG YANG HENG, SUNI G. ALLEN
Journal: British Journal of Dermatology (2008)

Journal Article Expression of the l‐fucose moiety on epidermal keratinocytes in psoriasis induced by the Koebner phenomenon: a sequential study Get access MADALENE C. Y. HENG, MADALENE C. Y. HENG Division of Dermatology, Department of Medicine, UCLA San Fernando Valley Internal Medicine Program, Veterans Administration Medical Center, Sepulveda, California, U.S.A. Madalene C.Y. Heng. UCLA School of Medicine, Chief, Division of Dermatology, Veterans Administration Medical Center, 16111. Plummer St. Sepulveda, CA 91343, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar SIANG YANG HENG, SIANG YANG HENG Division of Dermatology, Department of Medicine, UCLA San Fernando Valley Internal Medicine Program, Veterans Administration Medical Center, Sepulveda, California, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar SUNI G. ALLEN SUNI G. ALLEN Division of Dermatology, Department of Medicine, UCLA San Fernando Valley Internal Medicine Program, Veterans Administration Medical Center, Sepulveda, California, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 126, Issue 6, 1 June 1992, Pages 575–581, https://doi.org/10.1111/j.1365-2133.1992.tb00102.x Published: 01 June 1992
Impact of high-throughput screening in biomedical research
Authors: Ricardo Macarron, Martyn N. Banks, Dejan Bojanic, David J. Burns, Dragan A. Cirovic, Tina Garyantes, Darren V. S. Green, Robert P. Hertzberg, William P. Janzen, Jeff W. Paslay, Ulrich Schopfer, G. Sitta Sittampalam
Journal: Nature Reviews Drug Discovery (2011)
Scintigraphic Visualization of an Epigastric Sentinel Node in Recurrent Breast Cancer After Lumpectomy and Postoperative Radiation Therapy
Authors: Renata Milardovic, Ivan Castellon, Christopher Mills, M Erkan Altinyay, Barbara Raphael, Hussein M. Abdel-Dayem
Journal: Clinical Nuclear Medicine (2006)

Sentinel node imaging and biopsy have become standard procedures for staging early breast cancer. Positive sentinel lymph node (SLN) biopsy necessitates the need for axillary lymph node dissection (ALND). Failure to visualize a sentinel lymph node in recurrent breast cancer after treatment by surgery, chemotherapy, and high-dose postoperative radiation therapy is almost the case in every patient. The reason for failure to visualize the sentinel node is the fibrosis that follows high-dose radiotherapy and blocks the lymphatics preventing spread of the tumor cells to the lymph nodes. Alternative pathways for the drainage of lymph from the breast are developed in these patients. We have previously reported on the alternative pathways of lymphatics to the contralateral axilla, supraclavicular area, and also reported on the development of intramammary lymph nodes. In this report, we are presenting another alternative pathway of lymphatics to the region of the epigastrium below the lower end of the sternum.
Alpha-fetoprotein in Abortion
Authors: M. Seppala, E. Ruoslahti
Journal: BMJ (1972)

The clinical value of maternal serum alpha-fetoprotein (AFP) as a guide to the outcome of threatened abortion was assessed. After the thirteenth week of gestation, abortion occurred more frequently (10/12) in women with abnormal serum AFP levels than in those (2/12) whose AFP concentrations were within the normal range. Low levels were present in women with blighted ovum and high concentrations were associated with intrauterine fetal death. In legal first and second trimester abortions, the circulating maternal AFP levels in postabortion samples were often higher than before abortion, irrespective of whether abortion was performed instrumentally or induced with prostaglandins. Maternal serum AFP levels provide a new means for prediction of the outcome of threatened abortion.
Arginine, an indispensable amino acid for patients with inborn errors of urea synthesis.
Authors: S W Brusilow
Journal: Journal of Clinical Investigation (1984)

The role of arginine as an essential amino was evaluated in four children with one of the deficiencies of carbamyl phosphate synthetase, ornithine transcarbamylase, argininosuccinate synthetase, and argininosuccinase. Within 15-68 h after arginine deprivation nitrogen accumulated as ammonium or glutamine or both, but glutamine was quantitatively the largest nitrogen accumulation product. Concomitantly plasma and urinary urea levels decreased. Resumption of arginine intake (or citrulline in the case of ornithine transcarbamylase deficiency) promptly led to correction of the hyperammonemia, hyperglutaminemia and hypoargininemia. Ornithine was an unsatisfactory substitute for arginine. Arginine deprivation did not interfere with carbamyl phosphate synthesis as manifested by orotic aciduria. It is concluded that arginine is an indispensable amino acid for children with inborn errors of ureagenesis and its absence results in the rapid onset of symptomatic hyperammonemia.
New Museum Dedicated to Semmelweis
Authors: K. Farkas, S. Fekete, A. Palla
Journal: BMJ (1965)

BRIT reaction to oral phenoxymethylpenicillin in 1957.1Regarding treatment of any anaphylactoid reaction, I am sure prompt recognition is vital, and I am equally sure that prompt administration of adrenaline is the correct initial course because it is effective, acts quickly, and every doctor carries it in his bag.-Iam, etc., Leeds 17.
259 THE EFFECT OF BRANCHED-CHAIN AMINO ACIDS FOR REDUCTION OF LIVER FIBROSIS AND LIVER CANCER IN DIETHYLNITROSAMINE-INDUCED RAT MODEL OF HEPATOCELLULAR CARCINOMA WITH LIVER CIRRHOSIS
Authors: J.H. Cha, S.H. Bae, H.L. Kim, E.S. Choi, N.I. Han, Y.S. Lee, E.S. Jung, J.Y. Choi, S.K. Yoon
Journal: Journal of Hepatology (2012)
`Benadryl" for Penicillin Urticaria
Authors: R. R. Willcox
Journal: BMJ (1946)

Case 8.-Primipara, aged 25.Delivered at another hospital and admitted 9/5/46 on account of an infected perineal laceration, for which she was being treated with sulphamezathine.The baby was not admitted.10/5/46: T. 1000 F. (37.80 C.); P. 100.Tender flushed left breast.Lactation suppressed with stilboestrol.Peni- cillin begun and sulphamezathine discontinued.11/5/46: T. 100°F.(37.80 C.); P. 104.Slight flush and tenderness over an area the size of a penny.12/5/46: T. 99.60 F. (37.550C.); P. 86.Breasts normal.15/5/46: T. 980 F. (36.70 C.); P. 80. Penicillin dis- continued.Total dosage, 500,000 Oxford units.Case 9.-Para-3, aged 32.5/6/46: Normal delivery.Breast- feeding begun.12/6/46: T. 99.60 F. (37.550C.); P. 90.Outer and lower quadrant of left breast flushed and tender.Penicillin started.13/6/46: T. 97.6°F.(36.40 C.); P. 88. Flush almost gone.Slight tenderness.14/6/46: T. 97.80 F. (36.550C.); P. 86.Breast normal.18/6/46: T. 970 F. (36.10 C.); P. 80. Penicillin dis- continued.Total dosage, 500,000 Oxford units.Case 1O.-Para-2, aged 26.9/6/46: Normal delivery.Breast- feeding begun.17/6/46: T. 1000 F. (37.80 C.); P. 120.Flush, tenderness, and induration in inner and lower quadrant of right breast.Penicillin started.18/6/46: T. 98°F.(36.7°C.);P. 110.Severe pain in breast.Stilboestrol 3 mg.As breast-feeding did not increase the pain it was continued.19/6/46: T. 970 F. (36.10 C.); P. 84.Flush decreased.Localized hardening the size of a walnut.20/6/46: T. 97.6°F.(36.40 C.); P. 84.Breast normal. 22/6/46: T. 97.60 F. (36.40 C.); P. 72.Penicillin discontinued.Total dosage, 500,000 Oxford units.
Monkey Stressed, Monkey Drinks
Authors: Joan Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Purine and Pyrimidine Ribosides on an Isolated Frog Ventricle Preparation
Authors: MARGARET H. COOK, ERNEST A. GREENE, VICTOR LORBER
Journal: Circulation Research (1958)

Various purine and pyrimidine ribosides, with the exception of adenosine, have been found to exhibit a positive inotropic effect on an isolated strip of frog ventricle. In a preparation responding maximally to one compound, the addition of a second compound led to a further increase in tension. This relationship was found to apply among the members of a given group (purine or pyrimidine) paired in various combinations, as well as in experiments pairing purine against pyrimidine riboside. Adenosine showed brief stimulation followed by depression, pure depression or no effect.
Abstract 3879: YAP (Yes-associated protein), a proposed tumor suppressor in breast cancer, is regulated by cyclin D1
Authors: Sophie Lehn, Nicholas P. Tobin, Göran Landberg
Journal: Cancer Research (2010)

Abstract In breast cancer, cyclin D1 over-expression and amplification has been linked to a worse prognosis. Conversely, lower levels of cyclin D1 have also been correlated to an unfavorable outcome. We have in our previous studies observed that lower levels of cyclin D1 correlate to a more migratory phenotype of breast cancer cells. In order to specifically delineate the possible effectors downstream of cyclin D1, we performed a whole-genome microarray experiment where cyclin D1 was downregulated in MDA-MB-231 cells. To avoid selecting for pure cell cycle-dependent changes, the cell cycle-related binding partners of cyclin D1; cyclin-dependent kinases 4 and 6 (Cdk4/6), were also downregulated and included in the microarray experiment. One of the top downregulated genes upon cyclin D1 silencing was YAP, a recently proposed tumor suppressor gene implicated in regulation of breast cancer cell migration. We set out to clarify the link between cyclin D1 and YAP, both in an in vitro setting and by examining the expression of the two proteins in a clinical material of 179 primary invasive breast cancers. To validate the microarray results, cyclin D1 and Cdk4/6 protein levels were transiently silenced up to 96 h in MDA-MB-231 and MCF-7 breast cancer cells using siRNA, and YAP protein levels were observed by western blot. The clinical material was stained using YAP and cyclin D1 antibodies, and intensity of the signal was scored. Also, chromogenic in situ hybridization was performed allowing for assessment of amplification of the CCND1 gene. Transient downregulation of cyclin D1 in MDA-MB-231 and MCF-7 cells resulted in decreased YAP protein levels, as predicted by the microarray results. Downregulation of Cdk4/6 did not result in decreased YAP levels. In the clinical material, cyclin D1 intensity was inversely correlated to YAP intensity (Spearman's rho −0.220, P=0.031). Amplification of CCND1 was significantly correlated to none or low intensity of YAP expression. We conclude that on protein level, the silencing of cyclin D1 decreases levels of YAP independently of cyclin D1's cell cycle-dependent association with Cdk4/6. On the chromosomal level, CCND1 gene amplification is correlated to loss of YAP expression which might explain the inverse correlation seen between cyclin D1 and YAP in the clinical material. Studies to further characterize the link between cyclin D1, YAP and migration are ongoing. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3879.
Book: Ritalin Nation: Rapid-Fire Culture and the Transformation of Human Consciousness
Authors: S. R Wilkinson
Journal: BMJ (2001)

Richard DeGrandpre W W Norton, £9.95, pp 284 ISBN 0 393 32025 1 Rating: ![Graphic][1]</img> If children's behaviour becomes “out of hand” it is understandable that parents may seek a diagnosis to explain it away. There are several to hand. Ritalin Nation looks at one such diagnosis—attention deficit disorder. Richard DeGrandpre proposes that US culture has medicalised child development and that attention deficit disorder is a child strategy for coping with … [1]: /embed/inline-graphic-1.gif
The Enzyme-Linked Immunosorbent Assay Method for IgG Antibody to Purified Protein Derivative in Cerebrospinal Fluid of Patients with Tuberculous Meningitis
Authors: Steve B. Kalish, Robert C. Radin, Doris Levitz, C. Raymond Zeiss, John P. Phair
Journal: Annals of Internal Medicine (1983)

Three patients with culture-proven Mycobacterium tuberculosis meningitis were studied. Analysis of cerebrospinal fluid with an enzyme-linked immunosorbent assay (ELISA) method measuring IgG antibody to purified protein derivative rapidly yielded positive results, whereas results of acid-fast smears were negative and cultures took several weeks before growth appeared. We did serial studies of cerebrospinal fluid and sera from one patient. Initially, greater amounts of IgG antibody to purified protein derivative were present in the cerebrospinal fluid than in the serum. The antibody level in the cerebrospinal fluid paralleled the patient's clinical course, cerebrospinal fluid cell count, protein level, and glucose level. Cerebrospinal fluid samples from 33 hospitalized control patients were negative for antibody to purified protein derivative. The ELISA method measuring IgG antibody to purified protein derivative should be evaluated as a means of early diagnosis and management of patients with suspected tuberculous meningitis.
EFFECT OF RECENT ANTIGEN PRIMING ON ADOPTIVE IMMUNE RESPONSES
Authors: J. Sprent, J. F. A. P. Miller
Journal: The Journal of Experimental Medicine (1973)

When spleen, mesenteric lymph node, or Peyer's patch cells from mice primed 24 h before with either sheep erythrocytes (SRC) or horse erythrocytes (HRC) were transferred together with both SRC and HRC to irradiated mice, antibody responses measured 7 days later were very low to the priming antigen but high to the other antigen. This was demonstrated either by measuring numbers of antibody-forming cells in spleen or levels of hemagglutinins in serum. Specific unresponsiveness of the transferred cells was evident in both the 19S and 7S responses. It was observed only when strict experimental conditions were followed: (a) the cell donors had to be primed with not less than 109 erythrocytes given intravenously; (b) the cells had to be transferred between 1 and 2 days after antigen priming; (c) antibody responses in the recipients were measured within 7 days of cell transfer, i.e., partial recovery was evident by 11 days; (d) the transferred cells had to be challenged in the recipients within 1 day after cell transfer: when challenge was delayed for 5 days or longer, responsiveness returned. The failure of cells from recently primed donors to respond to the priming antigen on adoptive transfer could be overcome by supplementing with normal spleen cells, but not with thymus alone or bone marrow alone. This implied that unresponsiveness occurred at the levels of both T and B lymphocytes, and was not due to a suppressive influence exerted by T cells. Further work is in progress to determine the mechanism of this transient state of specific unresponsiveness.
EFFECTS OF RHEOLYTIC THROMBECTOMY AND MANUAL THROMBUS ASPIRATION ON INFARCT SIZE AND MICROVASCULAR OBSTRUCTION DURING PRIMARY ANGIOPLASTY: SMART–MRI SUBSTUDY
Authors: Nazario Carrabba, Guido Parodi, Akiko Maehara, Silvia Pradella, Angela Migliorini, Renato Valenti, Stefano Colagrande, Gary Mintz, David Antoniucci
Journal: Journal of the American College of Cardiology (2013)
Diagnosis of Trauma
Authors: Bharti R. Patel
Journal: JAMA (1983)

To the Editor.—  In reference to a question regarding potential complications after injuries sustained by a patient in a vehicular accident (QUESTIONS AND ANSWERS, 1982;248:1510), we offer the following comments. As stated by Dr Ben Eiseman, injuries to the thorax and abdomen by hitting against the steering wheel may cause substantial intrathoracic and intraabdominal trauma in a patient who may exhibit stable clinical status and normal vital signs.  The potential injuries cited included rupture of the liver or spleen, traumatic rupture of the diaphragm, severed subclavian artery, ruptured aorta, and pulmonary and myocardial contusions. All of these injuries are fraught with the potential of serious consequences if not recognized and treated. One would like either to document or rule out the presence of these injuries in the least invasive manner and in as short a duration as possible.  Depending on the available facilities at the treatment center, a combination of
Abstract 2143: Inhibiting fatty acid synthase for chemoprevention of chemically induced colorectal tumors
Authors: Hajime Orita, Sigekazu Tanaka, Hiroshi Maekawa, Mutsumi Sakurada, Tomonori Kushida, Tomoaki Ito, Masahiro Miyazaki, Toshihiko Shiroishi, Koichi Sato
Journal: Cancer Research (2014)

Abstract Purpose: Fatty acid synthase (FAS) is overexpressed in colorectal cancer, and we have investigated the potential use of FAS inhibitors for chemoprevention of colorectal cancer. Experimental Design: Expression of FAS was evaluated in human colorectal lesions and in murine models of colorectal tumorigenesis [AOM and DSS induced colorectal tumors in mice]. Then, the ability of pharmacologic inhibitors of FAS to prevent development of the murine tumors was investigated. Results: Immunohistochemical studies show that human colorectal cancers express high levels of FAS compared with normal tissues, suggesting that FAS might be a target for intervention in colorectal carcinogenesis. FAS is also expressed at high levels in chemically induced murine colorectal tumors, and the numbers and sizes of those murine tumors are significantly reduced by treating carcinogen-exposed mice with berberine include, Chinese traditional drug, Kampo. Conclusions: We conclude that increased levels of FAS are common in human colorectal cancer. Based on studies in mouse models, it seems that inhibiting FAS is an effective strategy in preventing and retarding growth of colorectal tumors that have high expression of this enzyme. Citation Format: Hajime Orita, Sigekazu Tanaka, Hiroshi Maekawa, Mutsumi Sakurada, Tomonori Kushida, Tomoaki Ito, Masahiro Miyazaki, Toshihiko Shiroishi, Koichi Sato. Inhibiting fatty acid synthase for chemoprevention of chemically induced colorectal tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2143. doi:10.1158/1538-7445.AM2014-2143
The European Panel on Appropriateness of Gastrointestinal Endoscopy (EPAGE): Project and Methods
Authors: None Vader, None Burnand, None Froehlich, None Dubois, None Bochud, None Gonvers
Journal: Endoscopy (1999)

Following the introdcution of the fiberoptic gastroscope in the sixties and of the colonoscope in the early seventies, endoscopy has gradually supplanted gastrointestinal radiography as the initial diagnostic study for the majority of patients with suspected gastrointestinal pathology, except for conditions such as suspected small bowel disease, which are not readily accessible to endoscopic evaluation. Upper and lower gastrointestinal endoscopies together now represent the most frequent procedures performed in the US health care system, totaling almost 5 000 000 procedures in 1996 [1].
1166 Multi-center evaluation of the versant® HBV DNA 3.0 assay: assessment of analytical and clinical performance
Authors: J YAO, M BELD, L OON, C SHERLOCK, J GERMER, S MENTING, S THOE, L MERRICK, R ZIERMANN, J SURTIHADI
Journal: Hepatology (2003)

Tombusviruses, which are small plus-strand RNA viruses of plants, require the viral-coded p33 replication co-factor for template selection and recruitment into replication in infected cells. As presented in the accompanying paper [Shapka, N., Stork, J., Nagy, P.D., 2005. Phosphorylation of the p33 replication protein of Cucumber necrosis tombusvirus adjacent to the RNA binding site affects viral RNA replication. J. Virol. 343, 65–78.], p33 can be phosphorylated in vitro at serine and threonine residues adjacent to its arginine–proline-rich RNA binding site. To test the effect of phosphorylation on p33 function, in this paper, we used phosphorylation-mimicking aspartic acid mutants of Cucumber necrosis virus (CNV) p33 and in-vitro-phosphorylated p33 in gel mobility shift experiments. We found that phosphorylation inhibited the ability of p33 to bind to the viral RNA. In contrast, the nonphosphorylation-mimicking alanine mutants of p33 bound to viral RNA as efficiently as the nonphosphorylated wild type p33 did. In vitro assays with purified CNV replicase preparations revealed that phosphorylation-mimicking mutants of p33 did not support the assembly of functional CNV replicase complexes in yeast, a model host. Based on these results, we propose that the primary function of reversible phosphorylation of p33 is to regulate the RNA binding capacity of p33, which could affect the assembly of new viral replicase complexes, recruitment of the viral RNA template into replication and/or release of viral RNA from replication. Thus, phosphorylation of p33 might help in switching the role of the viral RNA from replication to other processes, such as viral RNA encapsidation and cell-to-cell movement in infected hosts.