tbuckley/cabot-search huggingface dataset:
Risk Factors for Airflow Obstruction in Recipients of Bone Marrow Transplants
Authors: JOAN G. CLARK
Journal: Annals of Internal Medicine (1987)

Obstructive lung disease is a complication of bone marrow transplantation. To identify risk factors we analyzed pulmonary function tests of 281 adult patients 1 year after marrow transplantation. The forced expiratory volume at 1 second divided by the forced vital capacity (FEV1/FVC) was used to measure airflow rates. Factors associated with a lower year-1 FEV1/FVC (%) included increased age (p less than 0.0001), male gender (p = 0.02), cigarette smoking (p = 0.01), lower FEV1/FVC before transplantation (p less than 0.0001), HLA-nonidentical grafts (p = 0.001), chronic graft-versus-host disease (p = 0.0002), and immunosuppressive therapy with methotrexate (p = 0.01). There was no significant association between the year-1 FEV1/FVC and underlying disease, dose of conditioning irradiation, or development of acute graft-versus-host disease. Linear multivariate regression analysis, after controlling for the FEV1/FVC before transplantation, shows both chronic graft-versus-host disease and administration of methotrexate independently associated with decrements in the year-1 FEV1/FVC. The combined occurrence of chronic graft-versus-host disease and methotrexate also was strongly associated with decreases in the year-1 FEV1/FVC, indicating an interaction of these risk factors.
Dynamic Radiology of Swallowing Disorders
Authors: O. Ekberg, R. Olsson
Journal: Endoscopy (1997)

Dysphagia is a common symptom from the oral cavity, pharynx and esophagus, and its causes may be morphological or functional. A biphasic barium swallow is the best way of evaluating these patients. Using a careful clinical history, and by tailoring the examination to the individual case, the radiologist is usually able to pinpoint the cause of the patient's complaints and suggest further diagnostic procedures and treatment.
Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus
Authors: Toshimitsu Yatagai, Shoichiro Nagasaka, Ataru Taniguchi, Mitsuo Fukushima, Tomoatsu Nakamura, Akira Kuroe, Yoshikatsu Nakai, Shun Ishibashi
Journal: Metabolism (2003)
Pitfalls of I-131 Whole Body Scan Interpretation
Authors: Demetrios J. Agriantonis, Lance Hall, Michael A. Wilson
Journal: Clinical Nuclear Medicine (2008)

Whole body iodine scans are routinely performed in the nuclear medicine department as part of the management of differentiated thyroid carcinoma. Similarly, radioactive iodine has a well-established role as an adjunct to thyroidectomy in the treatment of these patients. A thorough understanding of the normal, benign, and pathologic biodistribution of iodine is imperative for the nuclear medicine physician. This knowledge leads to the accurate determination of the presence of metastatic or recurrent carcinoma, and may even facilitate the accurate detection of an undiagnosed condition. Above all, correct image interpretation avoids unnecessary therapeutic doses. The authors describe 2 unusual examples of false positive findings in fluid-filled cavities that showcase the variety of nonmalignant entities one may encounter when interpreting metastatic surveys.
Early Results and Late Developments of the Waterston Anastomosis
Authors: DANIEL J. TAY, MARY ALLEN ENGLE, KATHRYN H. EHLERS, AARON R. LEVIN
Journal: Circulation (1974)

The early results and late developments are presented of a consecutive series of 36 patients who underwent anastomosis of the ascending aorta to right pulmonary artery during a six-year period for a variety of congenital malformations associated with cyanosis and severe pulmonary stenosis or atresia. Twenty-six were infants under one year of age, and 16 of these were under one month of age at the time of operation. The early operative mortality of 22% was related to the severity of the anomaly and the young age of the patient. There were no early deaths in those aged three months or more. If the anastomosis was patent, symptomatic relief was good. However, the long-term mortality was 53%. Except for one baby who died of an associated congenital anomaly, the deaths were related to some consequence of the Waterston anastomosis that was unforeseen at the time of its employment. These included obliteration of the anastomosis, kinking of the anastomosis with partial or complete interruption of continuity between right and left pulmonary arteries, obliteration of the right pulmonary artery, progressive severe obstruction to right ventricular outflow and decreased flow to the left lung, as well as the complications of an excessive shunt with cardiac failure and pulmonary vascular obstructive disease. One or more subsequent palliative operations were required in nine symptomatic patients. Of the ten children with tetralogy of Fallot who underwent later open-heart repair, four died because of the difficulty in takedown of the Waterston and relief of the acquired stenosis or atresia of the right pulmonary artery and of the right ventricular outflow tract and hypoplasia of the left pulmonary artery. This mortality rate of 40% in these tetralogies contrasts with a concurrent mortality rate of less than 5% in a consecutive series of 50 patients with a tetralogy who had not had a previous Waterston procedure. We believe that this form of palliation should be reserved for those symptomatic, cyanotic newborns who are candidates for palliative rather than reparative surgery and who are not suitable for a Blalock-Taussig or Potts anastomosis.
Protection of factor Xa from neutralization by the heparin-antithrombin complex.
Authors: J M Teitel, R D Rosenberg
Journal: Journal of Clinical Investigation (1983)

We have studied the accessibility of Factor Xa to neutralization by the heparin-antithrombin complex within plasma and whole blood. This serine protease was detected by measuring the concentrations of activation fragments (F2/F1+2) cleaved from prothrombin. The levels of F2/F1+2) were quantitated by means of a sensitive and specific radioimmunoassay. Our findings indicate that the binding of Factor Xa to "activated" platelets but not to phospholipid micelles results in the protection of the above enzyme from inactivation by the heparin-antithrombin complex. This sequestration of Factor Xa is not affected by the liberation of platelet release proteins or the molecular heterogeneity of the mucopolysaccharide preparations used. The magnitude of enzyme protection is strongly correlated with the extent of prothrombin activation at the time of heparin addition. On this basis, we suggest that high in vivo rates of thrombin generation may lead to the sequestration of Factor Xa on the platelet surface and hence allow this serine protease to resist the action of heparin until the complex is cleared from the circulation.
Rigid adhesive strapping tape: the effect of storage conditions on load, elongation and stiffness
Authors: S Gordon, J Mulligan
Journal: British Journal of Sports Medicine (2010)

A variety of rigid adhesive strapping tape is used widely for the prevention and conservative management of musculoskeletal injuries. There is limited information regarding intrinsic mechanical properties of different brands of tape and no information is available about the effect of storage temperature on these mechanical properties. Hence, comparison of intrinsic mechanical properties of currently available tape is required to assist consumers in the selection of tape storage conditions according to specific mechanical properties of tape. Six adhesive rigid tapes commonly available in Australia were selected. Two configurations of tape were tested to mimic an ankle strapping configuration. All testing was conducted in a climate and humidity controlled laboratory. At initial testing, eight samples of each configuration, of each tape were loaded-to-failure using a densitometer. A roll of each tape was then stored for 1 month under two conditions; in the refrigerator and in a sports bag in a car. All tapes were then retested. The intrinsic ability of each configuration to resist vertical tensile force was assessed by measuring tensile load and elongation at failure. Tape stiffness was determined using Young's modulus, the modulus of elasticity. Significant differences in tensile load and elongation to failure existed at initial testing and after storage when comparing different tapes. Significant changes in mechanical properties also occurred within tapes when comparing initial and post storage measures. To ensure tape quality is maintained, further research is needed to establish if the intrinsic mechanical properties of tape alter on-field tape performance and to determine how environmental and climatic storage variables influence the physical and chemical components of tape to enable selection of optimal storage conditions to maximise on-field performance.
Ranitidine and cimetidine
Authors: T. J. Humphries
Journal: JAMA (1984)

To the Editor.—  It is to be expected that a review of the recently approved H2-receptor antagonist, ranitidine, include reference to cimetidine, the pioneer drug in this group.  We believe, however, that in so doing, in his recent article on ranitidine appearing inThe Journal, Strum1has rendered a disservice not only to cimetidine but to the readers as well. The data he has chosen to present, plus his selection of contrasts and comparisons of the two drugs, have resulted in an unfairly balanced article to the detriment of cimetidine and one that is misleading in regard to both drugs. This imbalance is most prominent in the sections of the article dealing with efficacy and adverse effects.  In the Pharmacokinetics section, Dr Strum's discussion of a 100-mg dose of ranitidine seems irrelevant inasmuch as ranitidine is available only as a 150-mg tablet. He does not mention whether the data
Polyarteritis Nodosa-Induced Quadriplegia
Authors: David L. Smith, Julie A. Kim, Bennet Wang
Journal: Annals of Internal Medicine (1995)

Letters1 May 1995Polyarteritis Nodosa-Induced QuadriplegiaDavid L. Smith, Julie A. Kim, and Bennet WangDavid L. SmithOregon Health Sciences University, Portland, OR 97207., Julie A. KimOregon Health Sciences University, Portland, OR 97207., and Bennet WangOregon Health Sciences University, Portland, OR 97207.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-9-199505010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:An abrupt onset of quadriplegia without central nervous system or sensory impairment signifies a severe disturbance of lower motor neurons, peripheral nerves, neuromuscular junctures, or muscle fibers. If diffusely tender muscles are present in this setting, a drug-induced, toxic, metabolic, infectious, or inflammatory myopathy is suspected. Rhabdomyolysis occurs when skeletal-muscle cell integrity is substantially disrupted, dispersing cellular contents into vascular channels [1]. Marked elevation of serum creatine kinase levels and evidence of urinary myoglobin are hallmark features of rhabdomyolysis. Surgical factors associated with rhabdomyolysis are diverse; for rheumatic diseases, only forms of polymyositis are reported to cause ...References1. Gabow PA, Kaehny WD, Kelleher SP. The spectrum of rhabdomyolysis. Medicine (Baltimore). 1982; 61:141-51. Google Scholar2. Kagen LJ. Myogloblinemia and myoglobinuria in patients with myositis. Arthritis Rheum. 1971; 14:457-64. Google Scholar3. Kernohan JW, Woltman HW. Periarteritis nodosa. A clinicopathologic study with special reference to the nervous system. Arch Neurol Psych. 1938; 34:655-86. Google Scholar4. Haimovici H. Muscular, renal and metabolic complications of acute arterial occlusions: myonephropathic-metabolic syndrome. Surgery. 1979; 85:461-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: Oregon Health Sciences University, Portland, OR 97207. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAutoimmune and Inflammatory DisordersDiplopia and MyalgiaTransesophageal Echocardiography for Quantifying Size of Patent Foramen Ovale in Patients With Cryptogenic Cerebrovascular Events 1 May 1995Volume 122, Issue 9Page: 731-732KeywordsCreatine kinaseMuscle biopsiesMuscle cellsMusclesMyalgiaNecrosisRhabdomyolysisTendonsUrineVascular diseases Issue Published: 1 May 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
No Appointment Necessary? Ethical Challenges in Treating Friends and Family
Authors: Katherine J. Gold, Edward B. Goldman, Leslie H. Kamil, Sarah Walton, Tommy G. Burdette, Kathryn L. Moseley
Journal: New England Journal of Medicine (2014)

The authors discuss the ethical issues that can arise when physicians provide medical care to family members or friends, and they review the professional guidelines with respect to these cases.
RELATIONS OF PATHOLOGY.
Authors: LUDVIG HEKTOEN
Journal: JAMA (1904)

Ostwald, the inspiring interpreter of the great principles of science, states:  We have just passed through a period in which all sciences have been isolated, a period of specialization, and we find ourselves in an epoch in which the synthetic factors in science are gaining a constantly increasing significance. . . . Everywhere the individual sciences seek points of contact with one another; everywhere the investigator determines the value which his special results may have in the solving of the general problems. In short, all sciences are tending to be philosophical. Nowhere is this tendency toward fundamental explanation so great as in biology.  PATHOLOGY A DIVISION OF BIOLOGY.  Disease is the common lot of all forms of life—high as well as low, animal as well as vegetable—and it is the special province of pathology, the science of disease, to study life in its abnormal forms and
Abstract 4785: Identification of HSP105 as a novel non-Hodgkin lymphoma (NHL) restricted antigen
Authors: Serenella M. Pupa, Roberta Zappasodi, Italia Bongarzone, Antonello Cabras, Gaia C. Ghedini, Lorenzo Castagnoli, Francesca Micciché, Massimo A. Gianni, Massimo Di Nicola
Journal: Cancer Research (2010)

Abstract We recently reported that vaccination using dendritic cells (DCs) loaded with killed autologous tumor cells in relapsed indolent NHL patients induced objective clinical responses that correlate with multifaceted immunological responses. In particular, since responders (R) showed tumor-restricted humoral immunity in autologous setting, we exploited antibody (Ab) repertoires from vaccinated patients to evaluate whether the observed antibody responses was directed to indolent NHL-shared antigens (ags). Immunohistochemistry and flow-cytometric analyses of biotinylated Immunoglobulins (Igs) from vaccinated patients’ serum samples preadsorbed on normal isolated B cells in the attempt to decrease Abs cross-reacting with normal auto-ags showed that only post-vaccine serum Ig of responders specifically reacted with higher intensity on allogeneic NHL tumors (either long term cell cultures or primary tumors from the same series) compared to matched biotinylated Igs from control samples (pre-vaccine serum from responders, pre- and post-vaccine serum from non-responders and healthy donors). In addition, only Abs contained in post-vaccine serum from R significantly inhibited NHL DOHH2 cells growth strongly suggesting the presence of therapeutic Abs in their serum samples. These findings indicate that Igs from R recognize tumor cell-surface associated molecules different from patient-specific idiotypes and support the potential expression of novel NHL-restricted ags. As a step toward identifying NHL-restricted ags as potential novel therapeutic targets, we applied a properly modified serological proteome analysis (SERPA) using as target DOHH2 cells and as probes pre- and post-vaccine Ab repertoires from our series. Proteins, fractionated using an OFFGEL IPG strip (pH 3-10), were separated on SDS-PAGE and then immunoblotted with pre- and post-vaccine Igs from R and controls. Differential hybridization analyses have revealed some potential candidate tumor-associated antigens which include heat shock protein 105 (HSP105), whose immunological role has been already proved in solid tumors. Preliminary data indicate that HSP105 is also expressed on cell membrane from different tumor B cell lines and experiments are in progress to evaluate its potential implication in tumor growth control. Partially supported by AIRC. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4785.
The New Sentinel Network — Improving the Evidence of Medical-Product Safety
Authors: Richard Platt, Marcus Wilson, K. Arnold Chan, Joshua S. Benner, Janet Marchibroda, Mark McClellan
Journal: New England Journal of Medicine (2009)

In 2007, Congress directed the Food and Drug Administration (FDA) to create a new postmarketing surveillance system that will, by 2012, be using electronic health data from 100 million people to prospectively monitor the safety of marketed medical products.1 This new system is intended to complement existing systems of "spontaneous" adverse-event reporting. In May 2008, the FDA announced the Sentinel Initiative, which would "access the capabilities of multiple, existing data systems (i.e., electronic health record systems, medical claims databases)."2 The network of data systems is intended both to detect signals (i.e., higher-than-expected rates of adverse outcomes) and to confirm signals, . . .
Activated platelets signal chemokine synthesis by human monocytes.
Authors: A S Weyrich, M R Elstad, R P McEver, T M McIntyre, K L Moore, J H Morrissey, S M Prescott, G A Zimmerman
Journal: Journal of Clinical Investigation (1996)

Human blood monocytes adhere rapidly and for prolonged periods to activated platelets that display P-selectin, an adhesion protein that recognizes a specific ligand on leukocytes, P-selectin glycoprotein-1. We previously demonstrated that P-selectin regulates expression and secretion of cytokines by stimulated monocytes when it is presented in a purified, immobilized form or by transfected cells. Here we show that thrombin-activated platelets induce the expression and secretion of monocyte chemotactic protein-1 and IL-8 by monocytes. Enhanced monokine synthesis requires engagement of P-selectin glycoprotein-1 on the leukocyte by P-selectin on the platelet. Secretion of the chemokines is not, however, directly signaled by P-selectin; instead, tethering of the monocytes by P-selectin is required for their activation by RANTES (regulated upon activation normal T cell expressed presumed secreted), a platelet chemokine not previously known to induce immediate-early gene products in monocytes. Adhesion of monocytes to activated platelets results in nuclear translocation of p65 (RelA), a component of the NF-kappaB family of transcription factors that binds kappaB sequences in the regulatory regions of monocyte chemotactic protein-1, IL-8, and other immediate-early genes. However, expression of tissue factor, a coagulation protein that also has a kappaB sequence in the 5' regulatory region of its gene, is not induced in monocytes adherent to activated platelets. Thus, contact of monocytes with activated platelets differentially affects the expression of monocyte products. These experiments suggest that activated platelets regulate chemokine secretion by monocytes in inflammatory lesions in vivo and provide a model for the study of gene regulation in cell-cell interactions.
Reactive Lymphoid Hyperplasia after Omega-3 Fatty Acid Supplementation
Authors: Paul Ogden
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 November 1988Reactive Lymphoid Hyperplasia after Omega-3 Fatty Acid SupplementationPaul Ogden, MD, Veronica K. Piziak, MD, PhD, Phillip T. Cain, MD, W.R. Carpentier, BSN, MS, David F. Havemann, MDPaul Ogden, MDSearch for more papers by this author, Veronica K. Piziak, MD, PhDSearch for more papers by this author, Phillip T. Cain, MDSearch for more papers by this author, W.R. Carpentier, BSN, MSSearch for more papers by this author, David F. Havemann, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-10-843_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In recent years, omega-3 fatty acid (fish oil) supplementation has been widely studied for various reasons. It has been assumed that taking supplemental fish oil is innocuous; in fact, fish oil capsules are sold without Food and Drug Administration restrictions. We observed an unusual reaction to fish oil capsules not previously reported.In November 1987, a 68-year-old white woman enrolled in a randomized study of fish oil dosage. Except for hyperlipidemia, she was healthy. She was only taking vitamin supplements. She was randomly assigned to receive three Super EPA-600 capsules daily (Pharmacaps, Inc., Elizabeth, New Jersey). She...References1. Fish oil for prevention of atherosclerosis. Med Lett Drugs Ther. 1982;24:99-100. MedlineGoogle Scholar2. Fish oil for the heart. Med Lett Drugs Ther. 1987;29:7-9. MedlineGoogle Scholar3. GlauberWallaceGriverBrechtel HPKG. Adverse metabolic effect of omega-3 fatty acids in non-insulin-dependent diabetes mellitus. Ann Intern Med. 1988;108:663-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Scott and White Memorial Hospital Temple, TX 76508 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLymphadenopathy Two Years LaterPaul E. Ogden, MD8 Cardiovascular effects of ω-3 polyunsaturated fatty acids (fish oils) 15 November 1988Volume 109, Issue 10Page: 843-844KeywordsFatty acidsFood and Drug AdministrationHyperlipidemiaOils Issue Published: 15 November 1988 PDF DownloadLoading ...