tbuckley/cabot-search huggingface dataset:
Adequate pain relief is important in non-malignant conditions
Authors: L. A M Northcote
Journal: BMJ (1998)

EDITOR—All doctors must recognise the importance of adequate pain relief for non-malignant conditions,1 to which exactly the same principles apply as in the relief of malignant pain. There seems to be widespread reluctance to treat non-malignant pain with opiates, and yet surely pain is pain and deserves treating; this means giving whatever dose of whatever analgesic is required to relieve it.

There is no reason to withhold opiates if milder …
Reflex control of arterial blood pressure
Authors: J. T SHEPHERD
Journal: Cardiovascular Research (1982)

Journal Article Reflex control of arterial blood pressure Get access JOHN T SHEPHERD JOHN T SHEPHERD From the Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 16, Issue 7, July 1982, Pages 357–383, https://doi.org/10.1093/cvr/16.7.357 Published: 01 July 1982
Urethral Diverticulum in the Female
Authors: R. W. Weinberg, P. R. G. Gordon
Journal: BMJ (1967)

Laboratory (S.E.R.L.) at Baldock is to be congratulated on its development work on neutron generator tubes.It is no easy task to increase the output of D-T (deuteriumtritium) tubes, and the Baldock tubes with their present output of 10" neutrons per second and a tube life of the order of 100 hours or so are considerably better than simi- lar tubes developed in other countries.
Alterations in Serum Thyroid Hormonal Indices with Colestipol-Niacin Therapy
Authors: LINDA CASHIN-HEMPHILL
Journal: Annals of Internal Medicine (1987)

A serial blood-lipid-lowering study at the University of Southern California yielded unexpected findings on routine thyroid function monitoring. After 1 year of combined colestipol and niacin therapy, patients had reduced total serum thyroxine (T4) levels and increased triiodothyronine uptake ratios, an indicator of apparent decreases in thyroxine-binding globulin levels. Calculation of the free T4 index partially but not completely corrected for the apparent decrease in thyroxine-binding globulin, as determined by a relatively small decrease in the free T4 index compared with a large decrease in T4. Sequential sampling, using three separate methods, showed reduced thyroxine-binding globulin levels. The mechanism for these changes is unknown, but the fact that these patients were essentially euthyroid needs emphasis because the use of combined colestipol and niacin therapy is becoming more widespread.
Peripheral Nerve Involvement in Adult and Pediatric Patients With Central Nervous System Inflammatory Disease
Authors: Matteo Gastaldi, Enrico Marchioni
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
THE RAPID ESTIMATION OF THE QUANTITY OF CHLOROFORM VAPOUR PRESENT IN MIXTURES OF CHLOROFORM VAPOUR AND AIR
Authors: A. D. Waller, V. Geets
Journal: BMJ (1903)

Paris, 1846. 9 Loc. cit., Section III, p. 290. 10Med. Chir* Trans. xlLoc. cit., p. 30. 1* A natomy for Artists. * 3 Anatomy for Art Students, by Professor Arthur Thomson, and edition, 189g, pp. 37,121. 14 Topographische Anatomie, Zweiter Band, 1896, p. 185. 15 Curvature of the Spine, 2nd edition, p. 41. 16 Anatomie Artistique, 1890. 17 Loc. cit., p. 171. 18Loc cit., Part VII, Book I, p. 339. 19 British Medical Journal, March 5th, 1892. 0 British Medical Journal, March 5th, 1892.
STUDIES IN ASCORBIC ACID WITH ESPECIAL REFERENCE TO THE WHITE LAYER. I. DESCRIPTION OF METHOD AND COMPARISON OF ASCORBIC ACID LEVELS IN WHOLE BLOOD, PLASMA, RED CELLS, AND WHITE LAYER 12
Authors: Rose Lubschez
Journal: Journal of Clinical Investigation (1945)

Considerable data have accumulated on ascorbic acid levels in blood plasma (1), but reported data on the level of ascorbic acid in the white cell- platelet layer are limited (1 to 4).This is due to technical difficulties and to the quantity of blood required for a single determination.Estimations of ascorbic acid in whole blood have also been advocated as a means of reflecting the level in the white cell-platelet layer (6).Data on the relationship between the ascorbic acid level in the red cells and the plasma have also been presented (2, 7, 8).In this study, a relatively simple method is pre- sented which permits analysis of ascorbic acid levels in whole blood, plasma, red cells, and white layer in a single 4.5 ml.specimen of venous blood, together with analyses of ascorbic acid concentra- tions in whole blood, plasma, red cells, and white cell layer.A. METHODS
Estimation of sinoaortic baroreceptor heart rate reflex sensitivity and latency in man: a new microcomputer assisted method of analysis
Authors: S. A SMITH, T. J STALLARD, W. A LITTLER
Journal: Cardiovascular Research (1986)

A new method for analysing baroreflex sensitivity has been developed. It obviates the mathematical bias inherent in earlier methods and in addition provides a direct measurement of reflex latency. Sensitivity results obtained using this method in 25 patients with a wide range of ages and resting blood pressures were similar to, but consistently lower than, those achieved with the Oxford method. Baroreflex latency results ranged from 650 to 2900 ms (mean(SD) 1084(427) ms) and were reproducible within individuals. Sensitivity results were inversely related to age and resting systolic blood pressure. Reflex latency was not related to these variables or to resting heart rate or reflex sensitivity. This method was able to identify inadequate starting data and greatly reduced the analysis time.
Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer
Authors: Toru Hiraga, Shinae Kizaka-Kondoh, Kiichi Hirota, Masahiro Hiraoka, Toshiyuki Yoneda
Journal: Cancer Research (2007)

Abstract Hypoxia is a common feature of solid tumors and is associated with their malignant phenotype. The transcription factor hypoxia-inducible factor-1 (HIF-1) is a major regulator of adaptation to hypoxia and is implicated in the malignant progression of cancers. Here, we studied whether hypoxia and HIF-1 expression contribute to the development of bone metastases using a well-characterized animal model of bone metastasis in MDA-MB-231 human breast cancer cells. To study the role of hypoxia in bone metastases, we tested the effects of the fusion protein (TOP3), the oxygen-dependent degradation domain of HIF-1α fused with HIV-TAT, and procaspase-3. TOP3 selectively induced apoptosis in hypoxic tumor cells in vitro and significantly reduced bone metastases in vivo. We next examined the role of HIF-1 in bone metastases by establishing MDA-MB-231 cells overexpressing constitutively active or dominant-negative HIF-1α (MDA/CA-HIF or MDA/DN-HIF, respectively). Bone metastases of MDA/CA-HIF were significantly increased with elevated number of CD31-positive blood vessels. In contrast, bone metastases were significantly reduced in MDA/DN-HIF. Because the progression of osteolytic bone metastases is due in part to the imbalance between bone formation and bone resorption, we examined the effects of hypoxia and HIF-1 on the differentiation of osteoblasts and osteoclasts. Hypoxia and CA-HIF overexpression markedly inhibited osteoblastic differentiation, whereas hypoxia increased osteoclast-like cell formation. In conclusion, these results suggest that tumor-associated hypoxia and HIF-1 expression promote the progression of bone metastases in breast cancer. Our results also suggest that hypoxia and HIF-1 lead to the development of osteolytic bone metastases by suppressing osteoblast differentiation and promoting osteoclastogenesis. [Cancer Res 2007;67(9):4157–63]
Novel organism associated with chronic diarrhoea in AIDS
Authors: AveryS Hart, MarkT Ridinger, Ramesh Soundarajan, CarynS Peters, AndreaL Swiatlo, FrankE Kocka, R.P.H Logan, R.J Polson, V.S Kitchen, J.R.W Harris, J.H Baron, A.J Pinching
Journal: The Lancet (1990)
Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine.
Authors: W Lewis, J F Simpson, R R Meyer
Journal: Circulation Research (1994)

Zidovudine (azidothymidine [AZT]) inhibits human immunodeficiency virus replication and reduces the severity of acquired immunodeficiency syndrome. A limiting side effect of AZT is a mitochondrial cardiac and skeletal myopathy in which the pharmacologically active derivative of AZT (AZT triphosphate) plays a critical role. The present study determined biochemical mechanisms of AZT-induced mitochondrial toxicity and identified AZT triphosphate as an inhibitor of DNA polymerase-gamma in vitro. Inhibition kinetics were defined using purified bovine cardiac mitochondrial DNA polymerase-gamma and AZT triphosphate in vitro. The Km for deoxythymidine triphosphate was 0.8 +/- 0.3 mumol/L. AZT triphosphate incubation with DNA polymerase-gamma in vitro resulted in mixed kinetics with a competitive Ki of 1.8 +/- 0.2 mumol/L and a noncompetitive Ki' of 6.8 +/- 1.7 mumol/L. These Ki and Ki' values were strikingly higher than values for retroviral reverse transcriptase but lower than values for other cellular DNA polymerases. These data support previous molecular and morphological findings in clinical AZT mitochondrial myopathy and in models of AZT myopathy in vivo. Biochemical findings suggest that inhibition of mitochondrial DNA polymerase-gamma may be integral to the pathogenesis of AZT-induced myopathy.
Replication studies in various ethnic populations do not support the association of the HIF-2α SNP rs17039192 with knee osteoarthritis
Authors: Masahiro Nakajima, Dongquan Shi, Jin Dai, Aspasia Tsezou, Minghao Zheng, Paul E Norman, Atsushi Takahashi, Shiro Ikegawa, Qing Jiang
Journal: Nature Medicine (2011)
Measuring adrenal function in out-patients using topical corticosteroids
Authors: C.G. SPARKES
Journal: British Journal of Dermatology (1976)

A number of studies describing the effects on pituitary adrenal function of topically applied corticosteroids are reviewed. It is concluded that the adrenal function of the majority of out-patients is little affected by treatment with correctly prescribed topical corticosteroids. However, where patients need brief periods of treatment with large quantities of potent topical corticosteroids for extensive disease, clinicians should be aware of the possibility of transient adrenal suppression.
A new radiofrequency thermal balloon catheter for pulmonary vein isolation
Authors: Kazushi Tanaka, Shutaro Satake, Shigeru Saito, Saeko Takahashi, Yoshitaka Hiroe, Yusuke Miyashita, Shinji Tanaka, Michio Tanaka, Yoshio Watanabe
Journal: Journal of the American College of Cardiology (2001)
Therapeutic Effect of Lenalidomide in a Novel Xenograft Mouse Model of Human Blastic NK Cell Lymphoma/Blastic Plasmacytoid Dendritic Cell Neoplasm
Authors: Alice Agliano, Ines Martin-Padura, Paola Marighetti, Giuliana Gregato, Angelica Calleri, Celia Prior, Miriam Redrado, Alfonso Calvo, Francesco Bertolini
Journal: Clinical Cancer Research (2011)

Blastic natural killer (NK) cell lymphoma/blastic plasmacytoid dendritic cell neoplasm (BNKL) is a rare and aggressive neoplasia characterized by infiltration of blast CD4(+)/CD56(+) cells in the skin, the bone marrow, and peripheral blood. Currently, more efforts are required to better define molecular and biological mechanisms associated with this pathology. To the best of our knowledge, no mouse model recapitulated human BNKL so far.Primary bone marrow cells from a BNKL patient were injected in nonobese diabetes/severe combined immunodeficient interleukin (IL) 2rγ(-/-) mice with the intent to generate the first BNKL orthotopic mouse model. Moreover, because of the lack of efficient treatments for BNKL, we treated mice with lenalidomide, an immunomodulatory and antiangiogenic drug.We generated in mice a fatal disease resembling human BNKL. After lenalidomide treatment, we observed a significant reduction in the number of peripheral blood, bone marrow, and spleen BNKL cells. Tumor reduction parallels with a significant decrease in the number of circulating endothelial and progenitor cells and CD31(+) murine endothelial cells. In mice treated with lenalidomide, BNKL levels of active caspase-3 were significantly augmented, thus showing proapoptotic and cytotoxic effects of this drug in vivo. An opposite result was found for proliferating cell nuclear antigen, a proliferation marker.Our BNKL model might better define the cellular and molecular mechanisms involved in this disease, and lenalidomide might be considered for the future therapy of BNKL patients.
Accurate systolic wall thickening by nuclear magnetic resonance imaging with tissue tagging: Correlation with sonomicrometers in normal and ischemic myocardium
Authors: Joao A.C. Lima, Richmond Jeremy, William Guier, Sophie Bouton, Elias A. Zerhouni, Elliot McVeigh, Maurice B. Buchalter, Myron L. Weisfeldt, Edward P. Shapiro, James L. Weiss
Journal: Journal of the American College of Cardiology (1993)
Lichen Planus and Liver Disease
Authors: O. Epstein
Journal: British Journal of Dermatology (1984)

Journal Article Lichen Planus and Liver Disease Get access O. Epstein O. Epstein Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue 4, 1 October 1984, Pages 473–475, https://doi.org/10.1111/j.1365-2133.1984.tb06612.x Published: 01 October 1984
Doctors sued for uninterest, say researchers in US
Authors: J. Roberts
Journal: BMJ (1994)

Doctors who seem hurried and uninterested are at risk of being sued even if they practise good quality medicine, said researchers in the US last week. A team led by researchers from Vanderbilt University in Nashville, Tennessee, examined the malpractice records of obstetricians in Florida during 1987 and found that those who had higher levels of satisfaction among their patients also had lower rates of malpractice claims filed against them.

The study, published in JAMA, the Journal of the American Medical Association (1994;272:1583-7), was done …
Candida Albicans Infected Aortic Graft Detected by lndium-111 Oxine Labeled White Blood Cells
Authors: GARY G. WINZELBERG
Journal: Clinical Nuclear Medicine (1984)

A 74-year-old hypertensive male underwent a dacron graft repair for a ruptured lower thoracic aortic aneurysm. Four weeks later, fever developed with blood cultures positive for Candida Albicans. An indium-111 oxine white cell scan showed increased uptake in the graft. Chest CT demonstrated a large low attenuation mass surrounding the aortic graft. The mass had abnormal gas collection within it and abutted against the left mainstem bronchus. The patient's fever and positive cultures resolved on therapy, but the infected aneurysm ruptured into the left bronchus with fatal massive hemoptysis. This case demonstrates the utility of ln-111 oxine scanning in a patient with a fungal infected aortic graft.
Left Ventricular Hypertrophy Regression and Atrial Fibrillation Incidence
Authors: Mark H. Hyman
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THERMODILUTION-DERIVED CORONARY BLOOD FLOW PATTERN IMMEDIATELY AFTER CORONARY INTERVENTION AS A PREDICTOR OF MICROCIRCULATORY DAMAGE AND MID-TERM CLINICAL OUTCOMES AFTER ACUTE MYOCARDIAL INFARCTION
Authors: Masashi Fukunaga, Kenichi Fujii, Daizo Kawasaki, Kojiro Miki, Kenji Kawai, Tsuyoshi Nakata, Masahiko Shibuya, Mitsumasa Ohyanagi, Tohru Masuyama
Journal: Journal of the American College of Cardiology (2012)
Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis
Authors: Geoffrey C. Farrell, Claire Z. Larter
Journal: Hepatology (2006)

Nonalcoholic steatohepatitis (NASH), the lynchpin between steatosis and cirrhosis in the spectrum of nonalcoholic fatty liver disorders (NAFLD), was barely recognized in 1981. NAFLD is now present in 17% to 33% of Americans, has a worldwide distribution, and parallels the frequency of central adiposity, obesity, insulin resistance, metabolic syndrome and type 2 diabetes. NASH could be present in one third of NAFLD cases. Age, activity of steatohepatitis, and established fibrosis predispose to cirrhosis, which has a 7- to 10-year liver-related mortality of 12% to 25%. Many cases of cryptogenic cirrhosis are likely endstage NASH. While endstage NAFLD currently accounts for 4% to 10% of liver transplants, this may soon rise. Pathogenic concepts for NAFLD/NASH must account for the strong links with overnutrition and underactivity, insulin resistance, and genetic factors. Lipotoxicity, oxidative stress, cytokines, and other proinflammatory mediators may each play a role in transition of steatosis to NASH. The present “gold standard” management of NASH is modest weight reduction, particularly correction of central obesity achieved by combining dietary measures with increased physical activity. Whether achieved by “lifestyle adjustment” or anti-obesity surgery, this improves insulin resistance and reverses steatosis, hepatocellular injury, inflammation, and fibrosis. The same potential for “unwinding” fibrotic NASH is indicated by studies of the peroxisome proliferation activator receptor (PPAR) - γ agonist “glitazones,” but these agents may improve liver disease at the expense of worsening obesity. Future challenges are to approach NAFLD as a preventive public health initiative and to motivate affected persons to adopt a healthier lifestyle. (Hepatology 2006;43:S99-S112.)
Ryanodine sensitive calcium release channel from left ventricle, septum, and atrium of canine heart
Authors: L. Xu, A. H Cohn, G. Meissner
Journal: Cardiovascular Research (1993)

Objective: The aim was to consider the possibility that functionally distinct forms of the ryanodine sensitive calcium release channel are expressed in different regions of heart. Methods: Membranous fractions enriched in ryanodine binding activity were isolated from canine left ventricular free wall, interventricular septum, and atrium. Ryanodine receptors (RyR) were purified by sucrose density gradient centrifugation, following solubilisation of sarcoplasmic reticular membranes with the detergent Chaps. Single channel currents were measured, upon reconstitution of sarcoplasmic reticular vesicles and the purified RyR into planar lipid bilayers. Results: Ryanodine sensitive Ca2+ release channels from three different regions of canine heart displayed the same [3H]ryanodine binding and single channel characteristics. Conclusions: The left ventricular free wall, septum, and atrium of canine heart may express functionally related, if not identical, ryanodine receptor/Ca2+ release channels. Cardiovascular Research 1993;27:1815-1819
Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Authors: Simon Junankar, Gemma Shay, Julie Jurczyluk, Naveid Ali, Jenny Down, Nicholas Pocock, Andrew Parker, Akira Nguyen, Shuting Sun, Boris Kashemirov, Charles E. McKenna, Peter I. Croucher, Alexander Swarbrick, Katherine Weilbaecher, Tri Giang Phan, Michael J. Rogers
Journal: Cancer Discovery (2014)

Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton. However, because bisphosphonates bind rapidly to bone mineral, the exact mechanisms of their antitumor action, particularly on cells outside of bone, remain unknown. Here, we used real-time intravital two-photon microscopy to show extensive leakage of fluorescent bisphosphonate from the vasculature in 4T1 mouse mammary tumors, where it initially binds to areas of small, granular microcalcifications that are engulfed by tumor-associated macrophages (TAM), but not tumor cells. Importantly, we also observed uptake of radiolabeled bisphosphonate in the primary breast tumor of a patient and showed the resected tumor to be infiltrated with TAMs and to contain similar granular microcalcifications. These data represent the first compelling in vivo evidence that bisphosphonates can target cells in tumors outside the skeleton and that their antitumor activity is likely to be mediated via TAMs.Bisphosphonates are assumed to act solely in bone. However, mouse models and clinical trials show that they have surprising antitumor effects outside bone. We provide unequivocal evidence that bisphosphonates target TAMs, but not tumor cells, to exert their extraskeletal effects, offering a rationale for use in patients with early disease.
Treatment of Herpes Zoster with ACTH
Authors: David H. Appelman
Journal: New England Journal of Medicine (1955)

HERPES zoster is usually a benign condition followed by spontaneous recovery. However, it may have serious complications when it occurs in elderly patients or when it involves the eye. There is no specific treatment. It is in older patients with extensive involvement, and in those with herpes zoster ophthalmicus, that innumerable remedies have been tried, with no relief of the excruciating pain in the acute stage of the disease and no prevention of serious complications and sequelae. For this reason, it seemed worth while to report on the successful treatment of herpes zoster with ACTH in 4 such patients. Other . . .