tbuckley/cabot-search huggingface dataset:
MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
Authors: Ramiro Garzon, Shujun Liu, Muller Fabbri, Zhongfa Liu, Catherine E.A. Heaphy, Elisa Callegari, Sebastian Schwind, Jiuxia Pang, Jianhua Yu, Natarajan Muthusamy, Violaine Havelange, Stefano Volinia, William Blum, Laura J. Rush, Danilo Perrotti, Michael Andreeff, Clara D. Bloomfield, John C. Byrd, Kenneth Chan, Lai-Chu Wu, Carlo M. Croce, Guido Marcucci
Journal: Blood (2009)
Mononuclear cell subpopulations in the skin defined by monoclonal antibodies after HLA-identical sibling marrow transplantation
Authors: K. ATKINSON, V. MUNRO, E. VASAK, J. BIGGS
Journal: British Journal of Dermatology (1986)

Mononuclear cell subpopulations present in the skin of 36 recipients of HLA‐identical sibling marrow transplants were defined by immunoperoxidase using a battery of monoclonal antibodies to cell surface differentiation antigens. The T4‐positive (T4+) (helper‐inducer T cells), T8+ (cytotoxic‐suppressor T cells) and the T6+ (Langerhans cells) decreased in number early post transplant and returned towards normal numbers from day 42 onwards. There was no evidence that either the T4+ or the T8+ subset was involved in cell‐to‐cell contact damage in acute graft‐versus‐host disease (GVHD). The paucity of lymphoid cell infiltration of the epidermis in acute GVHD suggested the possibility of a soluble factor being responsible for basal layer damage. In patients with chronic GVHD there was no evidence of T4+ lymphocyte involvement, but T8+ lymphocytes were present in increased numbers, suggesting a role for the T8+ population in the skin lesions of chronic GVHD, or possibly a reflection of the pattern of T4+ and T8+ cell reconstitution in the blood post‐transplant. Finally, our study provided no evidence that B1+ (B cells), Leu 7+ (natural killer cells), OKM1+(histiocytes) or OKT10+ cells were involved in cell‐to‐cell contact damage in either acute or chronic GVHD.
A METHOD OF DETERMINING OCULAR DOMINANCE
Authors: A. C. DURAND
Journal: JAMA (1910)

The question of a dominant eye does not seem to be considered of any consequence by the medical profession or even by its ophthalmologists. Probably few, indeed, realize that one eye is chosen unconsciously for the more rapid, accurate, and delicate visual perceptions, just as the dextral hand is chosen by the right-handed for the performance of all the more delicate and expert tasks, especially in learning them. The significance of ocular dominance in its relation to sport has been brought out by a newspaper reporter, and in its relation to right-handedness and left-handedness, by an oculist in a volume so entitled. The value of the determination of the dominant eye in refraction needs further outworking and rating, but a simpler method of making the test than the one to be suggested could scarcely be found.  The idea of ocular dominance is by no means a new one. Ioan Baptista
Erythema elevatum diutinum with primary Sjögren syndrome associated with IgA antineutrophil cytoplasmic antibody
Authors: S. Shimizu, Y. Nakamura, Y. Togawa, N. Kamada, N. Kambe, H. Matsue
Journal: British Journal of Dermatology (2008)

Journal Article Erythema elevatum diutinum with primary Sjögren syndrome associated with IgA antineutrophil cytoplasmic antibody Get access S. Shimizu, S. Shimizu Department of Dermatology, Chiba University Graduate School of Medicine, 1‐8‐1 Inohana, Chuo‐ku, Chiba 260‐8670, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Nakamura, Y. Nakamura Department of Dermatology, Chiba University Graduate School of Medicine, 1‐8‐1 Inohana, Chuo‐ku, Chiba 260‐8670, Japan Correspondence: Yuumi Nakamura. E‐mail: yuumi@yamanashi.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Y. Togawa, Y. Togawa Department of Dermatology, Chiba University Graduate School of Medicine, 1‐8‐1 Inohana, Chuo‐ku, Chiba 260‐8670, Japan Search for other works by this author on: Oxford Academic Google Scholar N. Kamada, N. Kamada Department of Dermatology, Chiba University Graduate School of Medicine, 1‐8‐1 Inohana, Chuo‐ku, Chiba 260‐8670, Japan Search for other works by this author on: Oxford Academic Google Scholar N. Kambe, N. Kambe Department of Dermatology, Chiba University Graduate School of Medicine, 1‐8‐1 Inohana, Chuo‐ku, Chiba 260‐8670, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Matsue H. Matsue Department of Dermatology, Chiba University Graduate School of Medicine, 1‐8‐1 Inohana, Chuo‐ku, Chiba 260‐8670, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 3, 1 September 2008, Pages 733–735, https://doi.org/10.1111/j.1365-2133.2008.08676.x Published: 01 September 2008
Intrauterine Pressure and Fetal Heart Rate in Labor
Authors: Tom P. Barden, Richard W. Stander
Journal: JAMA (1963)

IN RECENT YEARS advances and refinements in the capabilities of complex electronic equipment have given great impetus to the study of the physiology of pregnancy. Most investigators have concentrated their efforts on specific areas of uterine or fetal physiology. At Indiana University Medical Center a primary effort has been the study of relationships between fetal heart rate and intrauterine pressure during labor. Fetal prognosis has long been based on fetal heart rate; however, the clinical practice of determining fetal heart rate by auscultation and averaging beats for a period of time does not reflect beat-to-beat variations. Continuous auscultation is impractical because of the interference created by uterine contractions and movement of the abdominal musculature. Many investigators have utilized methods of indirect fetal electrocardiography, and by plotting fetal heart rate as related to uterine contractions, they have added significantly to the knowledge of fetal cardiac function during labor. Such electrocardiograms, obtained
Toward Innovative Models of Health Care and Financing
Authors: Katharine R. Bazinsky, Laura Herrera, Joshua M. Sharfstein
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Single genetic mutations can account for melanocytic naevi
Authors: R.W. Blewitt
Journal: British Journal of Dermatology (2005)

Background The nature of melanocytic naevi is unknown notwithstanding their considerable significance for clinician and pathologist and despite the wealth of existing knowledge about melanocyte biology. Objectives To investigate how far a simple mutational model can explain the clinical and pathological features of melanocytic naevi, in particular their pattern of onset and frequency. Methods I have constructed a model of the development of the adult melanocyte population from a single stem cell. The total cutaneous melanocyte population in a human adult is already known, as well as the range of spontaneous mutation rates at a given gene site. For each cycle of mitosis during the post stem‐cell expansion of the melanocyte population, I calculate the accumulated number of cells likely to be mutated at a particular (although unknown) gene site. The results are interpreted in the light of a hypothesis that each of these mutant melanocytes will go on to form a melanocytic naevus. Comparisons are made with neurofibromas, occurring in type 1 neurofibromatosis and as sporadic lesions. Results A single genetic mutation in melanocyte precursors is found to be sufficient to explain the clinical and pathological features of melanocytic naevi. Conclusions I propose that melanocytic naevi are a consequence of single spontaneous genetic mutations which inevitably occur during the development of the adult population of cutaneous melanocytes.
Relative Erythrocythemia (Polycythemia) and Polycystic Kidney Disease, with Uremia
Authors: Dale G. Friend, Robert G. Hoskins, Maurice W. Kirkin
Journal: New England Journal of Medicine (1961)

RECENTLY polycythemia or erythrocythemia apparently associated with renal disease of several diverse types, including hydronephrosis,1 , 2 hypernephroma3 4 5 6 7 8 9 and renal adenoma10 and fibromyxoma,3 has been noted. To the best of our knowledge only 2 reports are available concerning the association of erythrocythemia and polycystic kidney disease.3 , 11 We recently studied a patient with polycystic kidney disease who presented originally as a diagnostic problem exhibiting a high blood urea nitrogen concentration, proteinuria, hypertension and a normal hematocrit. A normal hematocrit in the face of significant uremia was sufficiently unusual to prompt a study of the frequency of this association. It is the purpose of . . .
Artificial Heart Implants Began Five Years Ago
Authors: Virginia S. Cowart
Journal: JAMA (1987)

THIS WEEK marks not only the 20th year of heart transplants, but the fifth anniversary of the first artificial heart implant. William DeVries, MD, who implanted the first artificial heart in Barney Clark, DDS, Dec 1 to 2 (overnight), 1982, says he is still looking for a suitable patient to continue the artificial heart program at Humana Hospital, Louisville, adding that such a patient would not be a candidate for transplantation. This would probably mean someone over age 60 years whose heart is in poor condition but who is relatively healthy otherwise. "Humana is very strong in its commitment to us," DeVries says. He adds that he also has Food and Drug Administration approval to continue. DeVries likens the state of the art in artificial heart technology to the heart transplantation program before cyclosporine. "It's still developmental and experimental," he says, "but there is a place for another mode of
Decreased Cytotoxic Lymphocyte Counts in Alexithymia
Authors: Ratnin Dewaraja, Takeshi Tanigawa, Shunichi Araki, Akinori Nakata, Noriyuki Kawamura, Yukihiro Ago, Yuji Sasaki
Journal: Psychotherapy and Psychosomatics (1997)

Alexithymia is a psychological trait characterized by a difficulty in verbalizing feelings, which has been associated with a number of illnesses, including bronchial asthma and cancer.In order to understand how psychological variables such as alexithymia affect physical health, we compared the lymphocyte subsets of men (n = 97, mean 30.6) rated as high and low alexithymic when measured by the Toronto Alexithymia Scale (TAS). We analyzed our data by considering alexithymia a categorical variable, using TAS scores of 62 and below, and 74 and above, and by considering alexithymia a continuous variable, using the mean TAS score (64.01) separating high from low alexithymia.When alexithymia was considered a categorical variable, highly alexithymic men had significantly lower numbers of the most cytotoxic natural killer (NK) subset, (CD57-CD16+ cells). When alexithymia was considered a continuous variable, in addition to the NK subset, killer effector T cell (CD8+CD11a+ cells) count was also significantly lower. These results were obtained after controlling for possible effects of smoking and alcohol intake.These results suggest that the negative modulation of cellular immunity, especially the cytotoxic lymphocytes, may be one mechanism which, combined with other factors that have a negative effect on the immune system such as stress, results in the association between alexithymia and ill health. It is suggested that future studies should, in addition to cell counts, attempt to identify the effects of psychological variables on the cytolytic activity of cytotoxic lymphocytes. Furthermore, follow-up studies should monitor the subjects over the years to demonstrate that alexithymia-mediated negative modulation of the immune system results in clinical pathologies.
Abstract 3284: Genome-wide association study identifies new susceptibility loci of epithelial ovarian cancer in Han Chinese
Authors: Lian Li, Kexin Chen, Rongyu Zang, Quen Hao, Zhibin Hu, Dongxin Lin, Ding Ma, Weihua Jia, Hongbing Shen, Qingyi Wei
Journal: Cancer Research (2014)

Abstract Ovarian cancer is the leading cause of cancer death of gynecological malignancies in the world. To identify risk genetic variants for epithelial ovarian cancer (EOC), we performed a three-stage genome-wide association study (GWAS) in Han Chinese women. We scanned 900,015 single nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls of Chinese women. Forty-one promising SNPs were selected for replication in an independent sample set of 960 EOC cases and 1,799 controls of Chinese women. We further evaluated four significant loci in an additional replication population (492 EOC cases and 1,004 controls of Chinese women) and finally identified two new susceptibility loci at 9q22.33 (rs1413299 in COL15A1, Pmeta = 1.88 × 10-8) and 10p11.21 (rs1192691 near ANKRD30A, Pmeta = 2.62 × 10-8). In addition, two other loci at 12q14.2 (rs11175194 in SRGAP1, Pmeta = 1.14 × 10-7) and 9q34.2 (rs633862 near ABO and SURF6, Pmeta = 8.57 × 10-7) were consistently replicated (P&amp;lt;0.05 in all three stages). These results advance our understanding of the genetic susceptibility to EOC in Han Chinese. Citation Format: Lian Li, Kexin Chen, Rongyu Zang, Quen Hao, Zhibin Hu, Dongxin Lin, Ding Ma, Weihua Jia, Hongbing Shen, Qingyi Wei. Genome-wide association study identifies new susceptibility loci of epithelial ovarian cancer in Han Chinese. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3284. doi:10.1158/1538-7445.AM2014-3284
Parents' Roles in Decision Making for Children With Cancer in the First Year of Cancer Treatment
Authors: Jennifer W. Mack, Joanne Wolfe, E. Francis Cook, Holcombe E. Grier, Paul D. Cleary, Jane C. Weeks
Journal: Journal of Clinical Oncology (2011)

To evaluate the extent to which parents of children with cancer are involved in decision making in the ways they prefer during the first year of treatment.We conducted a cross-sectional survey of 194 parents of children with cancer (response rate, 70%) in their first year of cancer treatment at the Dana-Farber Cancer Institute and Children's Hospital (Boston, MA) and the children's physicians. We measured parents' preferred and actual roles in decision making and physician perceptions of parents' preferred roles.Most parents (127 of 192; 66%) wanted to share responsibility for decision making with their children's physician. Although most parents (122 of 192; 64%) reported that they had their preferred role in decision making, those who did not tended to have more passive roles than they wished (47 of 70; 67%; P < .001). Parents were no more likely to hold their ideal roles in decision making when the physician accurately identified the parents' preferred role (odds ratio [OR], 1.04; P = .92). Parents were less likely to hold more passive roles than they wished in decision making when they felt that physician communication (OR, 0.39; P = .04) and information received (OR, 0.45; P = .04) had been of high quality. Parents who held more passive roles than they wished in decision making were less likely to trust their physicians' judgments (OR, 0.46; P = .03).Most parents of children in their first year of cancer treatment participate in decision making to the extent that they wish; although, nearly one fourth hold more passive roles than desired. High-quality physician communication is associated with attainment of one's preferred role.
Ethical Aspects of Banking Placental Blood for Transplantation
Authors: Jeremy Sugarman
Journal: JAMA (1995)

Transplantation of blood cells harvested from the umbilical cord immediately after birth has been effective in repopulating the bone marrow. These placental blood transplantations may be safer than conventional bone marrow transplantations and may suspend the need to harvest bone marrow, a process fraught with difficulties. Further understanding and advancement of this emerging technology require developing large banks of placental blood. In this article, we examine some of the ethical issues associated with placental blood banking, including (1) questions about ownership of the tissue, (2) the necessity and nature of obtaining informed consent from parents for harvesting placental blood and the information-gathering process associated with it, (3) obligations to notify parents and children of the results of medical testing for infectious diseases and genetic information, (4) matters of privacy and confidentiality related to such information, and (5) the need for fair and equitable harvesting of and access to placental blood. (<i>JAMA</i>. 1995;274:1783-1785)
Abstract 5067: An expressed retrogene of master embryonic stem cell factor OCT4 alters prostate cancer susceptibility
Authors: Joan Breyer, Daniel Dorset, Travis Clark, Kevin Bradley, Tiina Wahlfors, Kate McReynolds, William Maynard, Sam Chang, Michael Cookson, Joseph Smith, Johanna Schleutker, William Dupont, Jeffrey R. Smith
Journal: Cancer Research (2014)

Abstract Genetic association studies of prostate and other cancers have identified a major risk locus at chromosome 8q24, but a causal gene and a mechanism for cancer predisposition has remained elusive. The locus harbors the POU5F1B retrogene and several non-coding RNA genes, and is also proximal to the MYC oncogene. The open reading frame of the retrogene is preserved with 96% identity to that of the parent POU5F1 gene on chromosome 6, encoding the master embryonic stem cell factor Oct4. We observed that 8q24 risk alleles are significantly correlated with reduced expression of the POU5F1B retrogene in normal prostate tissue. The alleles were not correlated with the expression of MYC or other flanking genes in normal prostate tissue. Predicted deleterious POU5F1B missense germline variants were also associated with risk of prostate cancer. Thus, two independent lines of genetic evidence support a potential causal role for POU5F1B in the transformation of normal prostate tissue. A plausible hypothesis of POU5F1B function is dysregulation of Oct4; POU5F1 is transcriptionally regulated by the encoded Oct4 transcription factor. The POU5F1B retrogene on 8q24 and POU5F1 on 6p21 were significantly co-expressed. These results suggest that a pathway critical to self-renewal of embryonic stem cells may also have a role in the origin of cancer. Note: This abstract was not presented at the meeting. Citation Format: Joan Breyer, Daniel Dorset, Travis Clark, Kevin Bradley, Tiina Wahlfors, Kate McReynolds, William Maynard, Sam Chang, Michael Cookson, Joseph Smith, Johanna Schleutker, William Dupont, Jeffrey R. Smith. An expressed retrogene of master embryonic stem cell factor OCT4 alters prostate cancer susceptibility. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5067. doi:10.1158/1538-7445.AM2014-5067
The influence of secretin on ion transport in the human jejunum
Authors: T. Hicks, L. A. Turnberg
Journal: Gut (1973)

Using a triple-lumen tube perfusion technique in normal human subjects secretin (2U/kg/hour intravenously) was shown to reduce the absorption of sodium, potassium, and chloride in the most proximal 30 cm of jejunum but it had no effect on bicarbonate absorption. This effect was not due to an artefact produced by the entry of secretin-stimulated, bicarbonate-rich, pancreatic juice into the test segment. Absorption of sodium chloride and water was stimulated rather than inhibited by higher bicarbonate concentrations and the effect of secretin was obvious even when this factor was controlled by adjusting the bicarbonate concentrations of the test fluids. Secretin did not influence ion transport in the mid-jejunum. It is suggested that the effects described may indicate a physiological role for secretin in the intestine where it could prevent the too rapid dehydration of upper jejunal contents which might interfere with adequate mixing and digestion.
Abstract 3476: Combined blockade of IGF-I receptor and VEGF for gastric cancer
Authors: Yasushi Adachi, Hiroyuki Yamamoto, Hua Li, Hirokazu Ohashhi, Masanori Ii, Yoshiaki Arimura, Takao Endo, Yasuo Kato, David P. Carbone, Kohzoh Imai, Yasuhisa Shinomura
Journal: Cancer Research (2010)

Abstract Background Insulin-like growth factor-I receptor (IGF-IR) signaling is required for tumorigenicity and tumor progression of gastrointestinal (GI) cancers. We have shown successful therapy for GI cancers using adenoviruses expressing dominant negative IGF-IR (IGF-IR/dn). On the other hand, IGF-IR signaling affects on vascular endotherial growh factor (VEGF) expression in some tumors. Here, we sought to evaluate the roles of IGF-IR on tumor angiogenesis and lymphangiogenesis and to develop targeting therapy for gastric cancer. Methods The impact of IGF signals on VEGF-A/C expression in gastric cancer cell was assessed. The effects of IGF-IR/dn alone and with bevacizumab on angiogenesis / lymphangiogenesis in mouse xenogfarts were assessed. Results IGFs induced expressions of VEGFs and up-regulated in vitro vascular vessel formation. IGF-IR/dn reduced those expressions and vascular formation. IGF-IR/dn down-regulated tumor size on mice via inhibiting both angiogenesis and lymphangiogenesis. The combination of IGF-IR/dn and bevacizumab was highly effective against tumors on mice. This combination reduced the expression of VEGF and induced apoptosis in the murine tumors most of all. Conclusions IGF-IR is involved in angiogenesis and lymphangiogenesis in gastric cancer. Targeting IGF-IR alone and with blocking VEGF may have therapeutic utility of prevention for gastric cancer progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3476.
Scintigraphy in Disseminated Coccidioidomycosis
Authors: ALBERT J. MORENO, JEROME L. BILLINGSLEY, MICHAEL N. LUNDY, JERRY M. BROWN, GORDON D. GRAHAM, TOMMY J. BROWN
Journal: Clinical Nuclear Medicine (1983)

MORENO, ALBERT J. M.D.; BILLINGSLEY, JEROME L. M.D.; LUNDY, MICHAEL N. M.D.; BROWN, JERRY M. M.D.; GRAHAM, GORDON D. M.D.; BROWN, TOMMY J. D.O. Author Information