tbuckley/cabot-search huggingface dataset:
Implantable Cardioverter-Defibrillators in patients with arrhythmogenic right ventricular Dysplasia/Cardiomyopathy
Authors: Ariel Roguin, Chandra S Bomma, Khurram Nasir, Harikrishna Tandri, Crystal Tichnell, Cynthia James, Julie Rutberg, Jane Crosson, Philip J Spevak, Ronald D Berger, Henry R Halperin, Hugh Calkins
Journal: Journal of the American College of Cardiology (2004)
Shall The Journal be Removed to Washington?
Authors: William T. Akins
Journal: JAMA (1891)

<h3>To the Editor:</h3> —Deeply interested in every move likely to contribute to the enhancement of material and scientific interests ofThe Journalwe regard as the exponent of the best literary and scientific culture of the first, best and largest medical organization of our country, I cannot but enter my personal protest against the removal of the "plant" and editorial management ofThe Journalfrom Chicago to Washington, D. C. Certainly no man of broad scholarship, literary and scientific culture, can find one incontrovertible argument in favor of the contemplated change. In every element of material advantage, and facilities for ready and quick distribution, no city in our country, when we regardThe Journal's constituency, is comparable to Chicago. And I feel assured no man will have the temerity to deny us such a measure of classical, special and general scholarship as render secure the best educational interests of
Providing Medical Care With Reduced Numbers of Residents
Authors: John Whyte
Journal: JAMA (1997)

Driven by the need to reduce the number of practicing physicians, the impact of international medical graduates (IMGs) is being examined more closely than ever. The AMA, along with 5 other groups, recently proposed elimination of the J-1 waiver, which allows IMGs to practice in an underserved area of the United States instead of returning to their home countries.<sup>1</sup>The Council on Graduate Medical Education proposed extending the J-1 visa return-home period from 2 to 5 years,<sup>2</sup>while eliminating Medicare funding for training IMGs. Congress, however, reauthorized the existing J-1 waiver in an add-on to the 1996 budget. Motivating proposals to reduce the number of IMGs is the dramatic increase in their number during the past 8 years. From 1988 to 1996, the number of IMGs in residency programs increased from 71000 to 77000.<sup>2</sup>The increase in IMGs is believed to be exacerbating physician oversupply. However, supporters
LYMPHANGIOGRAPHY IN DERMATOLOGY
Authors: Munro Dd, Craig O, Feiwel M
Journal: British Journal of Dermatology (1969)

Journal Article LYMPHANGIOGRAPHY IN DERMATOLOGY Get access DOWLING D. MUNRO, DOWLING D. MUNRO The Departments of Dermatology and Radiology, St Mary's Hospital, London, W.2 Search for other works by this author on: Oxford Academic Google Scholar OSCAR CRAIG, OSCAR CRAIG The Departments of Dermatology and Radiology, St Mary's Hospital, London, W.2 Search for other works by this author on: Oxford Academic Google Scholar MICHAEL FEJWEL MICHAEL FEJWEL The Departments of Dermatology and Radiology, St Mary's Hospital, London, W.2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 9, 1 September 1969, Pages 652–660, https://doi.org/10.1111/j.1365-2133.1969.tb16203.x Published: 01 September 1969 Article history Accepted: 30 January 1969 Published: 01 September 1969
Dioxin Revisited: Developments Since the 1997 IARC Classification of Dioxin as a Human Carcinogen
Authors: Kyle Steenland, Pier Bertazzi, Andrea Baccarelli, Manolis Kogevinas
Journal: Environmental Health Perspectives (2004)

In 1997 the International Agency for Research on Cancer (IARC) classified 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; the most potent dioxin congener) as a group 1 carcinogen based on limited evidence in humans, sufficient evidence in experimental animals, and extensive mechanistic information indicating that TCDD acts through a mechanism involving the aryl hydrocarbon receptor (AhR), which is present in both humans and animals. The judgment of limited evidence in humans was based primarily on an elevation of all cancers combined in four industrial cohorts. The group 1 classification has been somewhat controversial and has been challenged in the literature in recent years. In this article we review the epidemiologic and mechanistic evidence that has emerged since 1997. New epidemiologic evidence consists primarily of positive exposure-response analyses in several of the industrial cohorts, as well as evidence of excesses of several specific cancers in the Seveso accident cohort. There are also new data regarding how the AhR functions in mediating the carcinogenic response to TCDD. The new evidence generally supports the 1997 IARC classification.
Osteogenesis Imperfecta — Managing Brittle Bones
Authors: Joan C. Marini
Journal: New England Journal of Medicine (1998)

Osteogenesis imperfecta is an autosomal dominant disorder of the connective tissue, which is also known as “brittle-bone disease” because it renders those affected susceptible to fractures after minimal trauma. Clinically and biochemically, osteogenesis imperfecta is a generalized disorder of the connective tissue, characterized by various combinations of blue sclerae, triangular facies, macrocephaly, hearing loss, defective dentition, barrel chest, vertebral compression and scoliosis, progressive limb deformity and bowing, joint laxity, and varying degrees of growth retardation.The currently accepted classification of the disease includes four types defined according to clinical and radiographic features, with some overlap among them.1 Type I is . . .
Abstract SY23-02: Nanotechnology and single cell proteomics as a diagnostic tool
Authors: James R. Heath, Wei Wei, Young Shik Shin, Min Xue, Jing Zhou, Alex Sutherland, Jing Yu
Journal: Cancer Research (2014)

Abstract Single-cell functional proteomics assays can connect genomic information to biological function through the use of quantitative and multiplex protein measurements. Tools for single-cell proteomics have developed rapidly over the past 5 years, and are providing approaches for directly elucidating phospho-protein signaling networks in cancer cells, or for capturing high-resolution snapshots of immune system function in cancer patients participating therapies that involve immune system engineering and manipulation. We discuss advances in single cell proteomics platforms, with an emphasis the types of data that can be obtained, and how analysis of that data can provide deep insights into either designing therapies, or understanding patient responses to therapies. I will provide illustrative examples of how microchip-based single cell functional proteomics platforms are being applied to both fundamental biology and clinical studies. Citation Format: James R. Heath, Wei Wei, Young Shik Shin, Min Xue, Jing Zhou, Alex Sutherland, Jing Yu. Nanotechnology and single cell proteomics as a diagnostic tool. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr SY23-02. doi:10.1158/1538-7445.AM2014-SY23-02
Abstract P1-11-17: Neglected and Non-Neglected Locally Advanced Breast Cancer: Effects of Neoadjuvant Chemotherapy and Survival
Authors: NS El Saghir, NS El Asmar, M Abboud, ZK Nachef, HF Mikdashi, MA Hjeij, J Abbas, G. Abi Saad
Journal: Cancer Research (2010)

Abstract Background: Locally advanced breast cancer is a frequent clinical entity that compromises a biologically heterogeneous group that can also be divided chronologically by the duration between onset of symptoms and presentation for medical care. Methods: Retrospective review of all patients with locally advanced breast cancer (LABC) treated in a general oncology practice between 1997 and 2007. Patients with LABC at presentation and have available follow-up were included. Patients were staged or restaged according to AJCC 7th edition. Patients were divided between two groups: those who presented within 3 months of onset of symptoms and signs of disease (non-neglected) and those who presented after more than 3 months (neglected). DFS was calculated from time of diagnosis till time of distant recurrence or last follow-up. Overall survival was calculated from time of diagnosis till time of last follow-up or death. Study was approved by IRB of the American University of Beirut. Data was entered and analyzed using SPSS. Survival was calculated and estimated according to Kaplan Meier method. Results: Total number of patients with LABC was 109 pts. Median age at diagnosis was 48 yrs (Range: 21-78 y). Hormone receptors were positive in 71% of cases. Number of neglected cases at presentation were 61 patients and non-neglected 48. Pre-operative therapy, adjuvant chemotherapy, hormonal therapy and radiation therapy were conformal with standard current guidelines. Neoadjuvant chemotherapy was given in 24% (27/109) of all cases. Adjuvant trastuzumab was used starting June 2005. Patients were followed closely every three months and compliance with therapy was excellent. Overall Survival (OS) of all patients was 68% at 5 years and 34% at 10 years. Median Survival was 100 months for non-neglected and 62 months for neglected disease (P: 0.06) Survival data Conclusions: Locally advanced disease confers a bad prognosis and poor outcome in patients with breast cancer. Patients who present within 3 months of onset of symptoms have a better survival than those who present with neglected disease. Neglected disease, even though not necessarily biologically aggressive, continues to have an adverse effect on survival. Survival continues to decline between 5 and 10 years. Additional patient demographics and tumor characteristics as well as shorter delays at presentation will be presented. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P1-11-17.
Syphilitic aortic insufficiency. Its increased incidence in the elderly
Authors: T. A. Prewitt
Journal: JAMA (1970)

Fifty-six patients with aortic insufficiency, presumably syphilitic in origin, were encountered among 345 patients with a history of syphilis in a municipal clinic and hospital population. Little physical handicap and relative longevity characterized the involved patients. Of the syphilitic patients, 33% (9 of 27) of those over 70 years of age had aortic insufficiency, while only 7% (5 of 70) of those under 70 years of age were so involved. The venereal disease research laboratory test for syphilis was nonreactive in 30% (17) of these patients, whereas the more sensitive fluorescent treponemal antibody-absorption test was nonreactive in only 1.9% (1 of 53) of those with aortic insufficiency.
Effect of Low-calcium Diet on Urinary Calcium in Osteoporosis
Authors: S. D. Bhandarkar, B. E. C. Nordin
Journal: BMJ (1962)

retention are already suffering from a severe cardiovascular or respiratory disease.We shall always be faced with the problem of selection of cases for prostatectomy from among ageing men whose health is seriously impaired.If after three or four weeks of the best medical treatment improvement has occurred and morale is high, operation should be safe and is worth undertaking even though the patient's expectation of life is very limited.Between our first and second series of cases we abandoned the permanent suprapubic cystostomy in the treatment of urinary retention and we have not regretted it, for it is a token of the surgeon's despair.An indwelling Riches suprapubic or Gibbons urethral catheter, if carefully managed, can be retained for many weeks, and it leaves the way clear for a safe prostatectomy. SummaryTwo series of 200 cases each of urinary retention due to prostatic obstruction have been analysed.About 64% of each of these came to prostatectomy.Two- thirds of the remainder in each series died without being fit for operation.After an eight-year interval the mortality of those selected for prostatectomy fell from 15.5% to 6.2%.Infection and haemorrhage, major causes of death in those who underwent operation in the first series, played a much less significant part in the second series.Cardiovascular, respiratory, and cerebrovascular disorders, which often precipitate urinary retention, have become the most frequent causes of death after prostatectomy.They also account for the majority of deaths of those with urinary retention who never become fit for surgical treatment.We would like to acknowledge the work of three ward sisters-Miss M. Armstrong, Miss E. M. Brown, and Miss E. S. Stewart-without whose kindness and skill so many old men would never have regained their health.We also
BALKAN (ENDEMIC) NEPHROPATHY AND A TOXIN-PRODUCING STRAIN OF PENICILLIUM VERRUCOSUM VAR CYCLOPIUM: AN EXPERIMENTAL MODEL IN RATS
Authors: J.M. Barnes, R.L. Carter, G.C. Peristianis, P.K.C. Austwick, F.V. Flynn, W.N. Aldridge
Journal: The Lancet (1977)
Acute Lymphoblastic Leukemia And Histiocytic Medullary Reticulocytosis
Authors: Vaughan P. Simmons
Journal: JAMA (1975)

<h3>To the Editor —</h3> Dr David Shreiner's article was very interesting and has stimulated me to make the following comments. The chest roentgenogram showed an anterosuperior mediastinal mass that varied in size from time to time. The nature of the mass and its origin were not defined except to indicate that the mass was composed of malignant histiocytes. I suggest that the mass may have been of thymic origin and that it was the source of the abnormal cells, rather than a depository for them.<sup>1-3</sup> The illustrations of "erythrophagocytosis" may represent such a phenomenon, but I call attention to the possibility that the globules may not be red blood cells at all, but retained or phagocytosed glycoprotein globules secreted by these cells or others of the plasma cell line. The similarity of such globules to red blood cells has often deceived me and confused many other investigators in the
Protein Kinase Casein Kinase 2 Mediates Inhibitor-κB Kinase and Aberrant Nuclear Factor-κB Activation by Serum Factor(s) in Head and Neck Squamous Carcinoma Cells
Authors: Ming Yu, Jason Yeh, Carter Van Waes
Journal: Cancer Research (2006)

Abstract We showed previously that the signal transcription factor nuclear factor-κB (NF-κB) is aberrantly activated and that inhibition of NF-κB induces cell death and inhibits tumorigenesis in head and neck squamous cell carcinomas (HNSCC). Thus, identification of specific kinases underlying the activation of NF-κB could provide targets for selective therapy. Inhibitor-κB (IκB) kinase (IKK) is known to activate NF-κB by inducing NH2-terminal phosphorylation and degradation of its endogenous inhibitor, IκB. Casein kinase 2 (CK2) was previously reported to be overexpressed in HNSCC cells and to be a COOH-terminal IKK, but its relationship to NF-κB activation in HNSCC cells is unknown. In this study, we examined the contribution of IKK and CK2 in the regulation of NF-κB in HNSCC in vitro. NF-κB activation was specifically inhibited by kinase-dead mutants of the IKK1 and IKK2 subunits or small interfering RNA targeting the β subunit of CK2. CK2 and IKK kinase activity, as well as NF-κB transcriptional activity, was shown to be serum responsive, indicating that these kinases mediate aberrant activation of NF-κB in response to serum factor(s) in vitro. Recombinant CK2α was shown to phosphorylate recombinant IKK2 as well as to promote immunoprecipitated IKK complex from HNSCC to phosphorylate the NH2-terminal S32/S36 of IκBα. We conclude that the aberrant NF-κB activity in HNSCC cells in response to serum is partially through a novel mechanism involving CK2-mediated activation of IKK2, making these kinases candidates for selective therapy to target the NF-κB pathway in HNSCC. (Cancer Res 2006; 66(13): 6722-31)
Modulation of hepatic ferrochelatase activity by dietary manipulation of mitochondrial phospholipid fatty acyl groups†
Authors: Ann M. Kools, James G. Straka, Hazel D. Hill, Dorothy I. Whitmer, Ralph T. Holman, Joseph R. Bloomer
Journal: Hepatology (1989)

Ferrochelatase is an enzyme bound to the inner mitochondrial membrane, which is important in heme biosynthesis. Activity of purified ferrochelatase is affected by the presence of certain fatty acids. In the present study, we examined whether the activity of ferrochelatase is altered by dietary manipulation of the composition of mitochondrial membrane phospholipid fatty acylgroups. Rats were fed diets containing triolein, safflower or menhaden oil as 5% (w/w) of the diet. After 3 weeks, the animals were killed and liver mitochondria were isolated. Phospholipid fatty acid composition and ferrochelatase activity were assayed in the isolated mitochondria. Marked differences were seen. The proportion of oleic acid was highest in the triolein oil-fed group, that of linoleic and arachidonic acid was highest in the safflower oil-fed group and the proportion of eicosapentaenoic acid was highest in the menhaden oil-fed group. Ferrochelatase activity was greatest in the triolein oilfed group and lowest in the menhaden oil-fed group regardless of whether the mitochondria were intact, sonicated or sonicated and treated with Tween 20. Mixing of mitochondria from menhaden oil-fed rats with triolein oil resulted in a significant increase in ferrochelatase activity. Membrane fluidity and activities of the mitochondrial membrane enzymes succinic dehydrogenase and cytochrome oxidase did not differ among the groups. We conclude that dietary manipulation of mitochondrial membrane phospholipid fatty acyl group composition can directly modulate hepatic ferrochelatase activity. This has potential application in the treatment of protoporphyria, the genetic disorder in which ferrochelatase activity is deficient.
962-64 Determination of Extent of Viable Myocardium within Infarct-Related Arterial Perfusion Beds Using Intracoronary Tc-99m-Sestamibi Injection
Authors: Jeffrey I. Leavitt, Chanh Syravanh, Joseph A. Vita, Martha Nykiel, Donald E. Tow, Thomas P Rocco
Journal: Journal of the American College of Cardiology (1995)
Molecular Features of Follicular Variant Papillary Carcinoma of Thyroid: Comparison of Areas With or Without Classical Nuclear Features
Authors: Guven Guney, Gaye Guler Tezel, Kemal Kosemehmetoglu, Engin Yilmaz, Serdar Balci, Reyhan Ersoy, Bekir Cakir, Gulnur Guler
Journal: Endocrine Pathology (2013)
Indications for Bishydroxycoumarin (Dicumarol) in Acute Myocardial Infarction
Authors: HENRY I. RUSSEK, BURTON L. ZOHMAN, ALEXANDER A. DOERNER, ALLEN S. RUSSEK, LAVERE G. WHITE
Journal: Circulation (1952)

Many physicians find it difficult to decide whether or not a patient sustaining a mild episode of acute myocardial infarction should be treated with anticoagulant drugs. The Committee for the Evaluation of Anticoagulants in the Treatment of Coronary Occlusion with Myocardial Infarction (American Heart Association) has recommended the employment of such therapy in patients with this disease, unless contraindications to anticoagulant therapy exist. Data are presented to show that in "good risk" patients treated conservatively without anticoagulants, the mortality rate and incidence of thromboembolism are strikingly low. Consequently, even the maximum benefit theoretically obtainable from the employment of dicumarol in these cases is not sufficient to justify the hazard entailed in its use. It is therefore recommended that anticoagulants be employed only in the more serious attacks of the disease.
Length of storage of red blood cells does not affect outcome in critically ill children
Authors: Martin C. J. Kneyber, Roel P. Gazendam, Dick G. Markhorst, Frans B. Plötz
Journal: Intensive Care Medicine (2008)

Sir: Length of red blood cell (RBC) storage has been proposed a contributing factor to adverse outcome after RBC transfusion. This may be explained by an impaired ability to transport or deliver oxygen, or the presence of leukocytes in stored RBC preparations producing potential deleterious pro-inflammatory mediators or bioactive lipids [1]. We hypothesized that length of RBC storage might explain our previously observed independent association between RBC transfusion and increased mortality, duration of mechanical ventilation (MV) and length of paediatric intensive care unit (PICU) stay in critically ill children [2]. For each time a patient was transfused in our previous study, length of RBC storage was retrieved from our hospital’s blood bank [2]. Since we observed a dose-outcome relation between the number of RBC transfusions and mortality, we separately looked at single transfusion and multiple transfusions. The effect of RBC transfusion on oxygenation was assessed by the oxygenation index (OI, mean airway pressure times FiO2 divided by PaO2) and PaO2/FiO2 ratio. RBC preparations were leukocyte-depleted, but not irradiated. Statistical analysis was performed using the Student t-test; linear regression analysis was applied to study correlations. P  0.05 was accepted as statistically significant. Data of 295 patients were studied, of whom 67 (22.7%) were transfused; 39 (58.2%) were transfused only once, the remaining 28 received multiple transfusions at different time intervals (range 2–14) (Table 1). Seventeen (5.8%) patients died. The mean length of RBC storage was 16.7 ± 0.6 days [25–75% interquartile range (IQR) 9–23 days]. Length of RBC storage was comparable between survivors and non-survivors. This remained after comparing single versus multiple transfusions. Differences in OI and PaO2/FiO2 ratio between the first day and fifth day after transfusion, duration of MV and length of PICU stay were not correlated with length of RBC storage. Our findings indicate that our previous reported observed independent association between transfusion of leucocyte-depleted RBC preparations and increased morbidity in critically ill children could not be explained by length of RBC storage. Mortality was also not influenced by length of RBC storage, although our study might not be powered to detect this. To our knowledge, although the issue of RBC transfusion has been extensively studied in critically ill adults, no other paediatric data on length of RBC storage and outcome in critically ill children have been reported. Results from retrospective and prospective