The Felty Syndrome and G-CSF-Associated Thrombocytopenia and Severe Anemia
Authors: Theodore Wun
Journal: Annals of Internal Medicine (1993)

Letters15 February 1993The Felty Syndrome and G-CSF-Associated Thrombocytopenia and Severe AnemiaTheodore Wun, MDTheodore Wun, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-4-199302150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The Felty syndrome is the triad of rheumatoid arthritis, splenomegaly, and neutropenia. The use of recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) in patients with the Felty syndrome has yielded variable results [1, 2]. This is the second reported application of rG-CSF in a patient with the Felty syndrome [3].A 51-year-old white man with seropositive rheumatoid arthritis and absolute neutrophil counts ranging from 0.055 to 0.2 × 109/L for 10 years was referred for frequent sinopulmonary and skin infections. Examination showed splenomegaly and stigmata of rheumatoid arthritis; bone marrow examination was hypercellular with a left-shifted myeloid line consistent ...References1. Joseph G, Neustadt DH, Hamm J, Kellihan M, Hadley T. GM-CSF in the treatment of Felty syndrome. Am J Hematol. 1991; 37:55-6. Google Scholar2. Hazenberg BPC, Van Leeuwen MA, Van Rijswijk MH, Stern AC, Vallenga E. Correction of granulocytopenia in Felty's syndrome by granulocyte-macrophage colony-stimulating factor. Simultaneous induction of interleukin-6 release and flare-up of the arthritis (Letter). Blood. 1989; 74:2769-70. Google Scholar3. Ito T, Miyairi Y, Kuwabara T, Dan K, Nomura T. Granulocyte-colony stimulating factor corrects the granulocytopenia of Felty's syndrome (Letter). Am J Hematol. 1992; 41:318-9. Google Scholar4. Lieschke GJ, Burgess AW. Granulocyte colony-stimulating factor and granulocyte-macrophage colony stimulating factor. N Engl J Med. 1992; 327:28-35. Google Scholar5. Lindemann A, Herrmann F, Oster W, Haffner G, Meyenburg W, Souza LM, et al. Hematologic effects of recombinant human granulocyte colony-stimulating factor in patients with malignancy. Blood. 1989; 74:2644-51. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAn "impossible" harvest–GCSF-induced immune thrombocytopenia in an autologous stem cell transplant recipient with multiple myelomaFilgrastim induced thrombocytopeniaG-CSF-induced severe thrombocytopenia in a healthy donorSevere thrombocytopenia related to filgrastim mobilization in a healthy donorGranulocyte colony-stimulating factor (G-CSF)CYTOKINES AND CYTOKINE MODULATORSG-CSF-induced thrombocytopenia in a healthy donorProfound thrombocytopenia related to G-CSFGranulocyte colony-stimulating factor (G-CSF)Treatment of severe neutropenia due to Felty's syndromeor systemic lupus erythematosus with granulocyte colony-stimulating factorRe: Adverse Effect on Bone Marrow Protection of Prechemotherapy Granulocyte Colony-Stimulating Factor SupportReactivation of rheumatoid arthritis and development of leukocytoclastic vasculitis in a patient receiving granulocyte colony-stimulating factor for felty's syndromeSustained response in Felty's syndrome to prolonged administration of recombinant human granulocyte-macro-phage colony-stimulating factor (rhGM-CSF)Flare of arthritis with successful treatment of Felty's syndrome with granulocyte colony stimulating factor (GCSF)CD4+ T Cell-Ediated Leukopenia of Felty's Syndrome Successfully Treated with Granulocyte-Colony-Stating Factor and MethotrexateGranulocyte colony-stimulating factorCytokines and biological response modifiers in the treatment of infection 15 February 1993Volume 118, Issue 4Page: 318-319KeywordsBone marrowFelty syndromeGranulocyte colony stimulating factorNeutrophilsRheumatoid arthritisSkin infectionsSkin reactionSpleenSplenomegalyUltrasound imaging Issue Published: 15 February 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...