tbuckley/cabot-search huggingface dataset:
Senile Vaginitis Treated with Dienoestrol Cream
Authors: R. Murdoch, W. P. Black
Journal: BMJ (1959)

VENTRICULAR TACHYCARDIA WITH THYROTOXICOSIS MEDICBJOAn alternative mechanism of thyroid hormone acting directly on the myocardium, shortening the refractory period, warrants consideration.Summary A case history is described of a woman aged 31 with thyrotoxicosis who developed ventricular tachycardia.No recognized cause for this arrhythmia could be found.Our thanks are due to Dr. M.
Toxicity of Indomethacin
Authors: Hans L. Popper
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The article "Toxicity of Indomethacin" (<b>200</b>:552, 1967) deserves comment and critical objections. First, there is not the slightest proof in the reported case that the attack of acute pancreatitis was due to the indomethacin which the patient had been taking without ill effects for more than three months. Post hoc is not necessarily propter hoc. In the comment the author writes, "We ruled out biliary disease [as etiologic factor] because of a normal gallbladder series." This, however, is not mentioned in the report of the case, just as the gastrointestinal series taken two weeks after the onset is mentioned only in the comment. The author, moreover, does not seem to realize that a normal biliary tract, by x-ray or by inspection, (as published by me and others years ago) does not rule out a common channel between common bile duct and pancreatic duct, this common channel
Abstract 5776: Discovery of AMG 900, a highly selective, orally bioavailable inhibitor of aurora kinases with efficacy in preclinical antitumor models and activity against multidrug-resistant cells
Authors: Stephanie Geuns-Meyer, Victor J. Cee, Holly L. Deak, Bingfan Du, Brian L. Hodous, Hanh N. Nguyen, Philip R. Olivieri, Karina Romero, Laurie B. Schenkel, Vinod F. Patel, Xuhai Be, Tammy L. Bush, Grace Chung, Patrick Eden, Liyue Huang, Richard Kendall, Min-Hwa Jasmine Lin, Robert Radinsky, Beth Ziegler, Marc Payton
Journal: Cancer Research (2010)

Abstract The aurora family of serine/threonine kinases (Aurora-A, -B, -C) regulate cell-cycle progression in mammalian cells. Whereas aurora kinase C function appears restricted to meiosis in males, aurora kinases A and B are essential for proper chromosome congression, segregation, and cytokinesis during mitosis. Aurora kinases A and B have been implicated in tumorigenesis, with overexpression levels correlating to clinical staging of cancers and poor prognosis. Thus, these mitotic kinases have become the subject of much interest as targets for anticancer therapy. N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-phenyl-1-phthalazinamine was a key aurora kinase inhibitor lead, possessing oral bioavailability in rats that was lacking in the anthranilamide compounds from which it was derived. This phthalazine compound possessed a key feature that was deemed important to maintain in a clinical candidate: potency against a model multidrug resistant (MDR) cell line (MES-SA Dx5) commensurate with its activity against a cell line that does not overexpress P-gp (HeLa). Improved in vivo potency was desired, as measured by suppression of the phosphorylation of the aurora kinase B substrate Histone H3 on Ser10 six hours after dosing. SAR from targeting this improvement in in vivo activity uncovered a delicate balance between protein binding, pharmacokinetic parameters, and cell potency in MES-SA Dx5 cells. AMG 900 was identified as a suitable candidate for clinical development based on its low single digit nanomolar potency against MDR cell lines, robust PD response (with complete suppression of Histone H3 phosphorylation at six hours), and high selectivity against other kinases. Oral administration of AMG 900 at a well-tolerated dose of 4 mg/kg BID inhibited tumor growth (83% TGI; p &amp;lt; 0.0001) in an HCT116 xenograft model. AMG 900 is currently undergoing phase 1 clinical evaluation in patients with advanced solid tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5776.
Pulmonary function and health-related quality of life in a sample of long-term survivors of the acute respiratory distress syndrome
Authors: G. Schelling, C. Stoll, C. Vogelmeier, T. Hummel, J. Behr, H.-P. Kapfhammer, H.-B. Rothenhäusler, M. Haller, K. Durst, T. Krauseneck, J. Briegel
Journal: Intensive Care Medicine (2000)
Diffuse, Intense Lung Uptake on a Bone Scan
Authors: JAMES P. STRAIN, THOMAS C. HILL, J. ANTHONY PARKER, KEVIN J. DONOHOE, GERALD M. KOLODNY
Journal: Clinical Nuclear Medicine (2000)

Purpose Clinical and scintigraphic findings are described in a patient with unexpected diffuse lung uptake on bone scan after a heroin overdose. Methods The patient’s Tc-99m MDP bone scan is reviewed along with the pertinent clinical history and laboratory findings. Results Marked diffuse and symmetric lung uptake is present on bone scintigraphy in a patient with a history of acute renal failure and a markedly elevated calcium-phosphate product but normal renal function and laboratory values at the time of the examination. Conclusions The incidental observation of metastatic calcification by bone scintigraphy is important, because it may aid in the diagnosis of a previously unsuggested elevated calcium-phosphate product, renal failure, or both. Furthermore, the intensity of tracer localization on bone tracer–specific imaging may help evaluate the activity of the metastatic calcification process.
Unanswered questions about higher potency statins and the risk of new diabetes
Authors: J. J. Brugts
Journal: BMJ (2014)

Dormuth and colleagues conclude that the use of higher potency statins is associated with a moderate increase in new onset diabetes compared with lower potency drugs.1

I have several comments on this article.

Firstly, the authors categorised simvastatin 40 mg as a higher potency statin. This is one of the most commonly prescribed statins and in my opinion not one …
Intra-articular injections in capsulitis
Authors: F. E Bruckner
Journal: BMJ (1991)

instructions, Fenem, New York), but, given the circumstances in which it would most rewardingly be used-cardiac arrests, resuscitation on the ward or in the emergency room, and resuscitation outside hospital by paramedical staff-this is not enough.The device has been shown to be ineffective when wet2; when very cold; when contaminated with lignocaine, atropine, adrenaline, or bicarbonate
SEROLOGICALLY DEFINED AND LYMPHOCYTE-DEFINED COMPONENTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE MOUSE
Authors: Fritz H. Bach, Michael B. Widmer, Marilyn L. Bach, Jan Klein
Journal: The Journal of Experimental Medicine (1972)

The mixed leukocyte culture (MLC) test is an in vitro model of the recognition phase of the homograft response. For the most part, activation in MLC is dependent on differences of the major histocompatibility complex (MHC). Our present studies in the mouse suggest that activation is primarily associated with differences of genetic regions of the MHC other than those which control the serologically defined (H-2) antigens. These differences do not lead to cytotoxic or agglutinating antibody formation despite extensive immunization; we have called these differences lymphocyte-defined (LD) differences. The strongest stimulation in MLC is associated with differences of the Ir region. It is possible that the Ir product is the T cell receptor and that it is this same molecule which can act as the stimulatory agent in MLC. Other possibilities are discussed.
Prognostic Factors of Severe<i>Legionella</i>Pneumonia Requiring Admission to ICU
Authors: MUSTAFA EL-EBIARY, XAVIER SARMIENTO, ANTONI TORRES, SANTIAGO NOGUÉ, EDUARD MESALLES, MARÍA BODÍ, JORDI ALMIRALL
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Despite the fact that the epidemiology of community-acquired pneumonia and nosocomial Legionella infection is well known, there are no specific reports dealing with severe cases of Legionella pneumophila pneumonia admitted to intensive care units. We undertook a prospective study upon 84 patients with a reliable diagnosis of L. pneumophila pneumonia that required ICU admission. The study assessed the prognostic factors, clinical, radiological and outcome variables of both nosocomial (n = 33) and community-acquired (n = 51) cases of L. pneumophila pneumonia. The following variables were more common in nosocomial acquired as compared to community-acquired Legionella pneumonia: Chronic obstructive pulmonary disease (COPD) (64 versus 41%), cardiac disease (39 versus 10%), chronic renal failure (21 versus 4%), alcoholism (54 versus 18%), septic shock (33 versus 16%), and unilateral chest X-ray involvement (61 versus 39%). The crude mortality rate in this study was 30% (25 of 84) with no differences when comparing mortality between nosocomial (9, 27%) to community-acquired (16, 31%) types. The univariate analysis showed that cardiac disease, diabetes mellitus, creatinine ⩾ 1.8 mg/dl, septic shock, chest X-ray extension, mechanical ventilation, hyponatremia ⩽ 136 mEq/L, Pa CO2 /Fi O2 < 130, and blood urea levels ⩾ 30 mg/dl were factors related to poor outcome. On the other hand, the following two variables were related to better outcome: adequate treatment for Legionella and pneumonia improvement. The logistic regression analysis demonstrated that APACHE II score > 15 at admission (RR: 11.5; 95% CI 1.75 to 76.1; p = 0.025), and serum Na levels ⩽ 136 (RR: 21.3; 95% CI 1.11 to 408; p = 0.023), were the only independent factors related to death. On the other hand, improving pneumonia is associated with better outcome in Legionnaires' disease than for patients not having improving pneumonia (RR: 0.019; 95% CI: 0.036 to 0.106; p < 0.0001). A better understanding of the prognostic factors in cases of severe Legionella pneumonia will optimize our therapeutic approach in this disease and help to decrease both its mortality and morbidity rates. El-Ebiary M, Sarmiento X, Torres A, Nogué S, Mesalles E, Bodı́ M, Almirall J. Prognostic factors of severe Legionella pneumonia requiring admission to ICU.
Autopathography: the patient's tale
Authors: J. K Aronson
Journal: BMJ (2000)

Regulations to control of exposure to silica have existed in Australia since the 1930s, but hazard awareness is imperfect. To highlight the dangers of exposure to respirable silica dust, we describe a case of silicosis in a 52 year man whose exposure to silica was cutting and polishing engineered stone kitchen and bathroom countertops. The man presented with breathlessness, later complicated by bilateral spontaneous pneumothoraces requiring tube thoracostomies, and now requires lung transplantation. An Australian man worked as a stone cutter for &gt;20 years. Conditions were dusty. He used a paper mask irregularly in the later years. There was no health screening and only minimal dust extraction measures. He smoked 20 cpd for 20 years. He noticed breathless and cough in 2006 and was diagnosed with emphysema; after haemoptysis he was referred for specialist advice and tuberculosis was excluded. Lung function showed severe airflow obstruction with gas trapping and a DLCO of 40% predicted. A lung biopsy confirmed silicosis. CT is shown. He subsequently presented with bilateral non-contemporaneous pneumothoraces. This is the first case of silicosis associated with engineered stone described from Australia. This shows that silicosis still occurs despite occupational health &amp; safety regulations in developed countries. Such regulations are only as good as their implementation.
Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma
Authors: L Fouillard, M Bensidhoum, D Bories, H Bonte, M Lopez, A-M Moseley, A Smith, S Lesage, F Beaujean, D Thierry, P Gourmelon, A Najman, N-C Gorin
Journal: Leukemia (2003)
Extemporaneous Formulation Of Topical Corticosteroids
Authors: Kenneth H. Burdick
Journal: JAMA (1970)

To the Editor.—  Dr. Caldwell correctly and accurately summarizes the study we reported on the extemporaneous formulation of a corticosteroid formulation recommended in the literature. As he clearly perceives, there was little chance that Fischer's suggested prescription for triamcinolone could approach the activity of commercial triamcinolone acetonide creams. The lack of uniformity in these compounded prescriptions did prompt our comments on the possibility of vehicle effects on drug availability. As an industrial pharmacist, we are sure Dr. Caldwell is aware that such effects are well documented in the literature. There was, however, no intent to question the competence of the highly trained, professional people who serve as our community pharmacists. The article, instead, singles out a specific instance where the physician and pharmacist may innocently collaborate to present to the patient a medicament much less active than what is readily available commercially. We hoped that, as a consequence of this
Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project
Authors: Wing-yan Au, Dennis D. Weisenburger, Tanin Intragumtornchai, Shigeo Nakamura, Won-Seog Kim, Ivy Sng, Julie Vose, James O. Armitage, Raymond Liang
Journal: Blood (2008)
Possible modes of action of dobutamine in dog femoral and pulmonary arteries
Authors: H. MORISHITA, T. FURUKAWA
Journal: Cardiovascular Research (1980)

Possible mechanisms involved in the action of dobutamine on blood vessels in isolated strips of dog artery were investigated and compared with noradrenaline, dopamine, and isoprenaline. In femoral strips, noradrenaline, dopamine, and dobutamine induced a dose-dependent contraction which was blocked by phenoxybenzamine. In strips previously contracted by KCl, after pretreatment with phenoxybenzamine, dobutamine induced a further contraction while isoprenaline produced a dose-dependent relaxation. However, dobutamine and isoprenaline elicited a dose-dependent relaxation in strips contracted by noradrenaline without phenoxybenzamine. This isoprenaline-induced relaxation was completely blocked by propranolol but the dobutamine-induced relaxation was in part attenuated by propranolol. In pulmonary strips, noradrenaline and dopamine elicited a dose-dependent contraction which was blocked by phenoxybenzamine, whereas dobutamine did not act on the strips. beta-Blockade by propranolol tended to potentiate the dobutamine-induced contraction of femoral strips, but did not affect the responses of pulmonary artery to dobutamine. In pulmonary arteries, the contractile responses to noradrenaline were antagonised by dobutamine. The results obtained here indicate that dobutamine exerts vascular actions by several different modes, such as an alpha-adrenergic agonistic and antagonistic action, an extremely weak beta 2 agonistic action, and a non-adrenergic contractile action.
HEMORRHAGES IN SKIN LESIONS OF GUINEA PIGS FOLLOWING INTRAVASCULAR INJECTION OF TOXINS (SHWARTZMAN PHENOMENON)
Authors: Jules Freund
Journal: The Journal of Experimental Medicine (1934)

1. Filtrates from B. coli, B. typhosus, or meningococci injected into the skin of guinea pigs do not produce visible inflammation. When these injections are followed by intravascular injections of the same material, hemorrhages do not occur in the skin. 2. Guinea pigs sensitized to horse serum react with redness and edema to 0.1 or 0.01 cc. of horse serum injected into the skin, and subsequent intravascular injection of typhoid filtrate does not produce hemorrhage at the site of the reaction to horse serum. 3. When guinea pigs are injected into the skin with diphtheria toxin and these injections are followed by intravascular injection of filtrates from B. typhosus, hemorrhage occurs in the skin at the site of the reaction to diphtheria toxin. 4. When silver nitrate is injected into the skin of guinea pigs, redness, edema, and necrosis follow, and in a few guinea pigs small areas of hemorrhage can also be noticed. About half of the guinea pigs that have received an intravascular injection of typhoid filtrate react with hemorrhage at the site of the injection of silver nitrate.
Free Thyroxine and Free Thyroxine Index In Women Taking Oral Contraceptives
Authors: MARILYN A. SWANSON, THOMAS R. CUSTER, CATHLEEN M. SUEY
Journal: Clinical Nuclear Medicine (1981)

This study compares the accuracy of the free thyroxine index and free serum thyroxine radioassay in evaluating the metabolic status of 36 euthyroid women, 17 of whom were taking oral contraceptive drugs. Results indicate that the free thyroxine index does not uniformly compensate for estrogen-induced elevations in total serum thyroxine concentrations and that the free serum thyroxine is the test of choice in assessing the functional thyroid status of women taking oral contraceptive drugs.
Global public health and the information superhighway Epidemiologists are using the internet
Authors: M White, T Ostbye, M Smith, R Jones, S Kinn, J Sarangi, G Evans, R E LaPorte, S Akazawa, E Boostrom, M Campos, T Gamboa, R Gooch, H Lee, I Libman, E Marler, K Roko, F Sauer, N Tajima, W Wiebe
Journal: BMJ (1994)

EDITOR, — Ronald LaPorte and colleagues presented an impressive, though not unrealistic vision of an electronic future for public health.1 Many of us in public health have used Internet in some of the ways suggested.

In 1990 an electronic network for research and teaching in public health was established among epidemiologists in Hungary, Canada, Norway, Israel, and Australia.2 In 1991, to facilitate a European Community funded TEMPUS (Trans European Mobility Programme for University Studies) project aimed at developing education for a new public health in Hungary, we set up a listserver at the University of Western Ontario, Canada, linking 16 partners in six countries.3 This electronic mailing list has provided a mode of communication between partners, enabling rapid transfer of information and discussion of the project, as well as development of presentations and publications.

More recently, in Newcastle, a listserver has been set up as a part of the Mailbase system open to academics in public health.4 This list facilitates the sharing of information (on workshops, seminars, conferences, research grants, new ideas, etc) and promotes links, collaborative working, joint problem solving, and mutual support. It was initially intended for those working in the United Kingdom, but the membership has grown rapidly over 18 months and has spread to the rest of Europe and North America. At the outset the list was easily accessible only to academics, but the opening up of the information superhighway1 heralds the possibility of a much wider membership for the list, including those working in health services (such as public health physicians in Britain) and others in public sector and non- governmental organisations.

Electronic communication, especially computer conferencing, has also been used as a tool for distance education in epidemiology and biostatistics,5 breaking the isolation that is often felt by …
Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers
Authors: LiLi Jiang, Michelle KY Siu, Oscar GW Wong, Kar Fai Tam, Eric W-F Lam, Hextan YS Ngan, Xiao-Feng Le, Esther SY Wong, Hoi Yan Chan, Annie NY Cheung
Journal: Molecular Cancer (2010)

FBI-1 (factor that binds to the inducer of short transcripts of human immunodeficiency virus-1) is a member of the POK (POZ and Kruppel) family of transcription factors and play important roles in cellular differentiation and oncogenesis. Recent evidence suggests that FBI-1 is expressed at high levels in a subset of human lymphomas and some epithelial solid tumors. However, the function of FBI-1 in human ovarian cancers remains elusive.In this study, we investigated the role of FBI-1 in human ovarian cancers, in particularly, its function in cancer cell invasion via modulating membrane type 1-matrix metalloproteinase (MT1-MMP). Significantly higher FBI-1 protein and mRNA expression levels were demonstrated in ovarian cancers samples and cell lines compared with borderline tumors and benign cystadenomas. Increased FBI-1 mRNA expression was correlated significantly with gene amplification (P = 0.037). Moreover, higher FBI-1 expression was found in metastatic foci (P = 0.036) and malignant ascites (P = 0.021), and was significantly associated with advanced stage (P = 0.012), shorter overall survival (P = 0.032) and disease-free survival (P = 0.016). In vitro, overexpressed FBI-1 significantly enhanced cell migration and invasion both in OVCA 420 and SKOV-3 ovarian carcinoma cells, irrespective of p53 status, accompanied with elevated expression of MT1-MMP, but not MMP-2 or TIMP-2. Moreover, knockdown of MT1-MMP abolished FBI-1-mediated cell migration and invasion. Conversely, stable knockdown of FBI-1 remarkably reduced the motility of these cells with decreased expression of MT1-MMP. Promoter assay and chromatin immunoprecipitation study indicated that FBI-1 could directly interact with the promoter spanning ~600 bp of the 5'-flanking sequence of MT1-MMP and enhanced its expression in a dose-dependent manner. Furthermore, stable knockdown and ectopic expression of FBI-1 decreased and increased cell proliferation respectively in OVCA 420, but not in the p53 null SKOV-3 cells.Our results suggested an important role of FBI-1 in ovarian cancer cell proliferation, cell mobility, and invasiveness, and that FBI-1 can be a potential target of chemotherapy.
PWE-185 Use of Deep Sedation for a Percutaneous Gastropexy Service in a District General Hospital
Authors: N Siddique, C Nunes, A F Muller
Journal: Gut (2013)

<h3>Introduction</h3> All patients with head and neck cancer referred for nutritional support with enteral feeding to our unit undergo direct puncture gastropexy placement as per the British Society of Gastroenterology guidelines published in 2010<sup>1</sup>. On introduction of the new technique we observed that standard sedation with intravenous pethidine and midazolam often led to patients tolerating the procedures poorly and occasionally to the procedures being abandoned. Therefore a decision was made to continue these procedures with ‘deep’ sedation supervised with a consultant anaesthetist using remifentanil, midazolam and diamorphine. We present our data for the 18months until January 2013 using deep sedation. <h3>Methods</h3> The details of all patients attending for gastropexy procedures in East Kent between June 2011 and 11th January 2013 were reviewed to assess the type of sedation used, patient comfort (measured using the modified Gloucester score and assessed by the endoscopy nursing staff post-procedure) and complications. <h3>Results</h3> 35 patients (M: 31, F: 10, mean age 61, range 43yrs- 72yrs) underwent gastropexy procedures under deep sedation. The mean time taken to perform the procedure under deep sedation was 23.3 minutes +/- standard deviation of 4.6minutes. Range from 14–29 minutes. A total of 27 patients reported no discomfort and were resting comfortably throughout the procedure. 4 cases recorded to have experienced one or two episodes of mild discomfort but had tolerated the procedure well and 4 cases of minimal discomfort were reported, again the procedure was well tolerated. There were no reported complications (immediate or late). <h3>Conclusion</h3> Patients with head and neck cancers undergoing gastropexy procedures tolerate these procedures far better under deep sedation. We would recommend that such an approach improves the welfare of our patients and recommend its use to colleagues. <h3>Disclosure of Interest</h3> None Declared. <h3>Reference</h3> Westaby<i> et al.</i> The Provision of a Percutaneously Placed Enteral Feeding Tube Service. Gut 2010; 59: 1592- 1605