Hepatopulmonary Syndrome in Noncirrhotic Portal Hypertension
Authors: Binay K. De, Sambit Sen, Ranjan Sanyal
Journal: Annals of Internal Medicine (2000)

Letters6 June 2000Hepatopulmonary Syndrome in Noncirrhotic Portal HypertensionBinay K. De, MD, Sambit Sen, MBBS, and Ranjan Sanyal, MBBSBinay K. De, MDInstitute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (De)Institute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (Sen)Institute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (Sanyal)Search for more papers by this author, Sambit Sen, MBBSInstitute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (De)Institute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (Sen)Institute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (Sanyal)Search for more papers by this author, and Ranjan Sanyal, MBBSInstitute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (De)Institute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (Sen)Institute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (Sanyal)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-11-200006060-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hepatopulmonary syndrome (HPS), which consists of intrapulmonary vascular dilatation and impaired oxygenation in the setting of liver dysfunction or portal hypertension (1, 2), has predominantly been reported in patients with cirrhosis. We evaluated the frequency of this syndrome in noncirrhotic portal hypertension (1, 3).Twenty-five consecutive patients (16 men) with biopsy-proven noncirrhotic portal hypertension (24 with noncirrhotic portal fibrosis and 1 with portal-vein thrombosis) without cardiopulmonary disease were screened by air contrast–enhanced echocardiography. When results were positive, arterial blood gas analysis and pulmonary function tests were conducted. The HPS was diagnosed by positive contrast echocardiogram and a ...References1. Castro M, Krowka MJ. Hepatopulmonary syndrome. A pulmonary vascular complication of liver disease. Clin Chest Med. 1996;17:35-48. CrossrefMedlineGoogle Scholar2. Abrams GA, Nanda NC, Dubovsky EV, Krowka MJ, Fallon MB. Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: a new approach. Gastroenterology. 1998;114:305-10. CrossrefMedlineGoogle Scholar3. Abrams GA, Fallon MB. The hepatopulmonary syndrome. Clin Liver Dis. 1997;1:185-200. CrossrefMedlineGoogle Scholar4. Krowka MJ, Tajik AJ, Dickson ER, Wiesner RH, Cortese DA. Intrapulmonary vascular dilatations (IPVD) in liver transplant candidates. Screening by two-dimensional contrast-enhanced echocardiography. Chest. 1990;97:1165-70. CrossrefMedlineGoogle Scholar5. Rodriguez-Roisin R, Barbera JA. Hepatopulmonary syndrome: is NO the right answer? Gastroenterology. 1997;113:682-4. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Binay K. De, MD; Sambit Sen, MBBS; Ranjan Sanyal, MBBSAffiliations: Institute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (De)Institute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (Sen)Institute of Post Graduate Medical Education and Research; Calcutta, India 700 020 (Sanyal) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHipertensión portal idiopática no cirróticaHepatopulmonary Syndrome in children: a comparative study of non-cirrhotic vs. cirrhotic portal hypertensionEvaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the american association for the study of liver diseases, american society of transplantation and the north american society for pediatric gastroenterology, hepatoloIdiopathic noncirrhotic portal hypertensionHepatopulmonary syndrome in patients with Schistosoma mansoni periportal fibrosisHepatopulmonary syndrome: an updateLe syndrome hépatopulmonaireComparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in miceRelationship between vasoactive intestinal peptide and intrapulmonary vascular dilatation in children with various liver diseasesHepatopulmonary syndrome occurring after orthotopic liver transplantationREGIONAL AND SYSTEMIC HEMODYNAMIC DISTURBANCES IN CIRRHOSIS 6 June 2000Volume 132, Issue 11Page: 924KeywordsFibrosisGas analysisLiverLiver diseasesNitric oxidePathogenesisPortal hypertensionPulmonary functionPulmonary hypertensionThrombosis ePublished: 15 August 2000 Issue Published: 6 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...