tbuckley/cabot-search huggingface dataset:
Parathyroid Hyperplasia May Be Missed by Double-phase Tc-99m Sestamibi Scintigraphy Alone
Authors: ELISA M. CHEN, FRED S. MISHKIN
Journal: Clinical Nuclear Medicine (1997)

The authors report two cases of parathyroid imaging with double-phase Tc-99m sestamibi used in conjunction with Tc-99m pertechnetate that detected parathyroid hyperplasia when the wash out rate of MIBI from the glands paralleled normal thryoid tissue. Routine use of thyroid images for comparison may avoid this pitfall. The authors also observed that Tc-99m sestamibi has early uptake in brown tumors.
A call I never made
Authors: Anil Pandit
Journal: BMJ (2004)

When I was working as a resident in Patan Hospital, Kathmandu, on one busy on-call day, I was called by the emergency room resident to see a patient with possible myocardial infarction. The patient was being treated for congestive heart disease and had fainted that morning. His vital signs were stable and an electrocardiogram showed ST segment elevation and widened QRS complex, which were new findings. I made a quick diagnosis of acute myocardial infarction while chemistries were pending. I called an intensive care resident to find out if any beds could be arranged, but no beds were available. I decided to transfer the patient to the Heart …
Evidence and belief in ADHD
Authors: M. Zwi
Journal: BMJ (2000)

Attention deficit hyperactivity disorder (ADHD) generates controversy. Some believe that it does not exist, whereas others see the reluctance of clinicians to diagnose and treat it as denying effective health care to children.1 Epidemiological studies show that 3-5% of children of school age may be classified as having attention deficit hyperactivity disorder.2 No validated diagnostic test exists to confirm the clinical diagnosis.

It is a complex neurodevelopmental constellation of problems rather than a single disorder. The core symptoms are inattention, hyperactivity, and impulsivity. These are also, however, normal behavioural traits present in unaffected children. The extent to which each causes disability varies and should be seen within the context of a child's developmental level. For example, an active 3 year old, impulsive and frequently interrupting of others, differs from a disruptive, unfocused 8 year old who is unable to cope educationally. Yet both may display core symptoms. Also, it is important to establish that symptoms exist …
The Coronary Care Unit Turns 25: Historical Trends and Future Directions
Authors: THOMAS H. LEE
Journal: Annals of Internal Medicine (1988)

In the 25 years since the introduction of coronary care units the management of acute myocardial infarction has become oriented toward reducing infarct size and treating ongoing ischemia. The coronary care unit has been widely accepted as the standard of care for patients with acute myocardial infarction and has been considered appropriate for monitoring patients with acute chest pain until acute myocardial infarction is diagnosed or excluded. However, rising health care costs have created pressures to increase the efficiency of coronary care units. Possible strategies seek to decrease resource use by identifying low-risk patients for initial triage or early transfer to lower levels of care. The application of management algorithms and the development of intermediate care units as alternative triage sites for low-risk patients may be important future trends as a distinction is made between intensive coronary care and careful coronary observation.
USE AND OUTCOMES OF ANTIARRHYTHMIC THERAPY IN PATIENTS WITH ATRIAL FIBRILLATION RECEIVING ORAL ANTICOAGULATION: RESULTS FROM THE ROCKET AF TRIAL
Authors: Benjamin Steinberg, Anne Hellkamp, Yuliya Lokhnygina, Jonathan Halperin, Guenter Breithardt, Rod Passman, Graeme Hankey, Manesh Patel, Richard Becker, Daniel Singer, Scott Berkowitz, Christopher Nessel, Kenneth Mahaffey, Keith Fox, Robert Califf, Jonathan Piccini
Journal: Journal of the American College of Cardiology (2014)
Demonstration of Therapeutic Effect in a Patient with Myocardial Bridge by Exercise-Myocardial SPECT Imaging
Authors: KENICHI NAKAJIMA, JUNICHI TAKI, HISASHI BUNKO, NORIHISA TONAMI, AKIRA TADA, ICHIRO NANBU, KINICHI HISADA, MICHIO KAWASUJI, TAKASHI IWA
Journal: Clinical Nuclear Medicine (1985)

Myocardial bridge is generally considered to be a benign disorder involving the left anterior descending artery (LAD). In this paper, myocardial SPECT (single photon emission computed tomography) images in a patient who had myocardial bridging of the LAD are presented. Coronary arteriography demonstrated systolic compression of the LAD and a TI-201 stress SPECT study showed myocardial ischemia at peak exercise. After surgical decompression of the LAD, a TI-201 stress study showed normal perfusion. Stress TI-201 perfusion imaging provided objective evidence that a myocardial bridge was the cause of symptomatic myocardial ischemia, and was useful for the evaluation of the patient after therapy.
ON UNUNITED FRACTURES
Authors: G. W. Beresford
Journal: BMJ (1921)

rNUNITED FRACTURES.THz Baiinm 6_ MI LA Should a blood count be made, the combination may be present of enlarged cervical and otlher lymphatic glands, enlarged liver and spleen, togetlher with a certain degree of leucocytosis and a greatly increased percentage of lympho- cytes.Succh a group of phenomena was actually present in ono of our cases, and naturally suggested the possibility of acute leukaemia.It is not uncommon in the early
Natural and Postoperative History of 475 Patients with Proved Isolated Ventricular Septal Defects.
Authors: J. Gerard Mudd
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Natural and Postoperative History of 475 Patients with Proved Isolated Ventricular Septal Defects.J. Gerard Mudd, M.D., Vallee L. Willman, M.D., Leonard Fagan, M.D., Yavuz Aykent, M.D.J. Gerard Mudd, M.D.Search for more papers by this author, Vallee L. Willman, M.D.Search for more papers by this author, Leonard Fagan, M.D.Search for more papers by this author, Yavuz Aykent, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-820_5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOf the 475 patients with isolated ventricular septal defect diagnosed over the past 18 years by catheterization and cineangiography, 285 were observed for their natural history, and 190 had surgery. The unoperated patients were divided into two groups: those with pulmonary artery systolic pressure less than 50 mm Hg and those with pulmonary artery systolic pressure greater than 50. In the first group 238 patients have been observed 1 to 17 years and have shown no evidence of deterioration. Serial catheterization in 59 patients showed no progression of hypertension or shunt. Nine patients had spontaneous closure. Of 47 patients with... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. Gerard Mudd, M.D.; Vallee L. Willman, M.D.; Leonard Fagan, M.D.; Yavuz Aykent, M.D.Affiliations: St. Louis, Mo. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5 Page: 820-820 Keywords Catheterization Hypertension Pulmonary arteries Surgery Systolic pressure Ventricular septal defects ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
A METHOD FOR THE PRESERVATION OF CLEANLINESS ON PLASTER-OF-PARIS CASTS
Authors: Paul W. Greeley
Journal: JAMA (1934)

To the Editor:—  Members of the profession who use to any extent plaster-of-paris casts universally find that sooner or later the plaster becomes soiled. This is true especially with children, who during their activities ruin the clean appearance of the cast as it was originally applied. Parents as well as the patients themselves are constantly asking to have a new cast or the old one cleaned in order to make a more presentable appearance. Cleaning is, of course, practically impossible and one is loath to apply new casts.  This problem was recently solved for me by a patient. I have investigated the literature and have been unable to find the method described, although it is so simple that I would hardly feel fair in calling it original.  A cast had been applied to this man's hand, wrist and forearm for the care of a fractured carpal scaphoid bone. Shortly after
The Middle Time
Authors: Michael Aylward
Journal: Annals of Internal Medicine (2006)

On Being a Doctor7 February 2006The Middle TimeMichael Aylward, MDMichael Aylward, MDFrom the University of Minnesota, Minneapolis, MN 55453.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-3-200602070-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The people on the road just do not understand the need to drive a little faster, to brake a little less, and, generally, to get out of my way. Frustration and resentment are not too far under my skin after 30-odd hours of wakefulness and decision making.I barrel around a circular on-ramp that straightens out and immediately splits into 3 highways. I curse the confusing design as I drive by a single-file line of traffic to my right. Sheep, I think, they are all sheep, lining up good and early to keep me from getting home, getting to bed. ... Author, Article, and Disclosure InformationAffiliations: From the University of Minnesota, Minneapolis, MN 55453.Corresponding Author: Michael Aylward, MD, University of Minnesota, 420 Delaware Street SE, MMC 391, Minneapolis, MN 55453; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 February 2006Volume 144, Issue 3Page: 217KeywordsAnxietyChronic obstructive pulmonary diseaseDecision makingMemoryShouldersSleepSmellSweat ePublished: 7 February 2006 Issue Published: 7 February 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
<i>Pneumocystis carinii</i>in Hypopharyngeal Material
Authors: James W. Erchul, Lloyd P. Williams, Pearse P. Meighan
Journal: New England Journal of Medicine (1962)

RARELY has the clinical diagnosis of pneumonia due to Pneumocystis carinii been confirmed by ante-mortem demonstration of the organism in biologic material. It is therefore pertinent to report a case in which this organism was found in hypopharyngeal contents obtained before death. Since a number of case reports and reviews are available, a comprehensive survey will not be attempted.The clinical course combined with the so-called typical x-ray appearance of the chest is the usual means by which pneumocystis pneumonia has been suspected clinically. Few authors discuss the possibility of confirming the diagnosis by finding the organism in clinical material. . . .
Commentaries on the Cardiovascular Controversy by A Bril
Authors: A. Bril
Journal: Cardiovascular Research (1994)

Journal Article Commentaries on the Cardiovascular Controversy by A Bril Get access Antoine Bril Antoine Bril SmithKline Beecham Laboratoires Pharmaceutiques, Saint-Grégoire, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 6, June 1994, Page 926, https://doi.org/10.1093/cvr/28.6.926 Published: 01 June 1994
A NEW METHOD FOR THE RADICAL CURE OF VARICOSE VEINS.Read in the Section of Surgery and Anatomy, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: ERNEST LA PLACE
Journal: JAMA (1893)

Varicose veins of the lower extremities are among the most persistent and tormenting afflictions of adult age, not only because of our comparative ignorance of the absolute causes of the condition in the majority of cases, but especially because in the few cases where the cause can be clearly made out, it is almost a matter of impossibility to remove it. Varicose veins are produced either by an increased blood pressure within the veins, or by a diminished resistance of the vessel walls, or both. Whatever be the special cause, the eventual result is nearly always the same—a permanent state of dilatation and consequent thinning out of the walls of the veins on account of the sluggish circulation and increased blood pressure. We know how this condition reaches its climax in a rupture of the vein, giving a serious hemorrhage on the one hand, or if the affected vessels be
BMA guidance on assisted suicide violates human rights, barrister says
Authors: C. Dyer
Journal: BMJ (2012)

The BMA’s guidance to doctors whose patients request assisted suicide is “wrong,” and the General Medical Council’s draft guidelines on the issue would be unlawful if brought into effect, a leading health law barrister has told the High Court in London.

The BMA guidance advises doctors to “avoid all actions that might be interpreted as assisting, facilitating, or encouraging a suicide attempt” and gives examples such as advising patients on what constitutes a fatal dose or on antiemetics in relation to a planned overdose.

Philip Havers QC said that the BMA’s guidance, issued in July 2010, “discourages acts that do not, in fact, amount to an offence, acts that may be commendable and, most tellingly, acts the discouragement of which may violate the fundamental human rights of others.”

Havers is asking three senior judges to rule that the policy of the director of public prosecutions for England and Wales on prosecuting assisted suicide and …
US judge strikes down age restrictions for "morning after" contraceptives
Authors: M. McCarthy
Journal: BMJ (2013)

A federal judge has ordered the US Food and Drug Administration (FDA) to make levonorgestrel based emergency contraceptives, the so called “morning after” pills, available over the counter without age restrictions.

Before the ruling, the FDA had approved sale of the contraceptives to women aged 17 years and older without prescription, but required those aged 16 and younger to obtain a prescription before they could purchase the drug.

The FDA approved the emergency contraceptive, Plan B, as a prescription drug in 1999. This formulation consisted of two pills containing 0.75 mg each of the …
Cardiovascular Disease in Racial and Ethnic Minorities
Authors: Ruth Falik
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract C66: Impacts of ERK signaling on the regulation of antioxidant enzymes and ROS levels in human lung cancer cells exposed to lead acetate
Authors: Jia-Ling Yang, Chun-Yu Wang
Journal: Cancer Research (2011)

Abstract Lead compounds (Pb) are widespread environmental contaminants that have been evaluated as group 2A carcinogens. Recently, we showed that EGFR activation is an immediate response to Pb as a primary upstream molecule to initiate SFK and PKCα activation, and subsequently links to the Ras→Raf-1→MKK1/2→EKK signaling cascade. Also, activation of this signaling plays a defensive role against Pb genotoxicity. Here, we explore whether Pb disturbs the intracellular levels of antioxidant enzymes and reactive oxygen species (ROS), and whether ERK signaling modulates the oxidative stress elicited by Pb in CL3 human non-small-cell lung adenocarcinoma cells. We found that Pb lowered the protein levels of glutathione peroxidase-1 (GPX1) and catalase, yet it induced superoxide dismutase 2 (SOD2). The phenomena were reverted upon ERK inactivation or depletion. By contrast, forced expression of the MKK1/2→ERK signaling decreased GPX1 and catalase, but enhanced SOD2 protein levels. The activities of GPX1 and catalase, but not SOD2, were declined in Pb-treated cells, and blockage of ERK activation partially rescued the decreased GPX1 activity. On the other hand, Pb elevated intracellular ROS, and ERK inactivation further enhanced its levels. The antioxidant N-acetyl-cysteine markedly prevented the cytotoxicity of Pb during ERK inactivation. These results suggest that ERK activation could mediate in scavenging ROS toxicants following Pb; yet, this signaling also participates in down-regulation of GPX1 and catalase as well as up-regulation of SOD2 at the protein levels, which probably enhances the intracellular H2O2. Thus, ERK exhibits dual and opposing roles in modulating oxidative stress caused by Pb. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr C66.
Ambulatory Care of Patients With Left Ventricular Assist Devices
Authors: C. Schmid, D. Hammel, M. C. Deng, M. Weyand, H. Baba, T. D. T. Tjan, G. Drees, N. Roeder, C. Schmidt, H. H. Scheld
Journal: Circulation (1999)

Left ventricular assist devices (LVAD) have revolutionized the treatment of patients with acute and chronic heart failure as they provide a high quality of life. We report on our experience with patients receiving ambulatory care after LVAD implantation.Since July 1995, 46 patients with a mean age of 45+/-11 years underwent implantation of an electrically driven LVAD with portable controller and batteries. Sixteen (35%) patients bridged >30 days were treated in part on an outpatient basis. After LVAD implantation, they were treated in the hospital for 86+/-32 days (range 40 to 153 days). Afterward, they received ambulatory care for 74+/-76 days (range 2 to 301 days, total experience 1206 days). In 13 cases, the outpatient treatment was interrupted by 1.7+/-1.7 readmissions, for a total of 32+/-42 days (median 19 days). Reasons for readmission included systemic or drive line infections (incidence 0.0066 per outpatient day), suspected or true thromboembolic events (incidence 0.0066 per outpatient day), and suspected malfunction of the LVAD. One patient supported as alternative to transplantation died after cerebral bleeding after 244 days, 1 patient with a history of acute myocarditis had ventricular fibrillation during LVAD assist while being at home for 177 days and died in a low output state, 10 patients were given transplantation after a mean support interval of 206+/-88 days, and 4 patients currently await heart transplantation.Outpatient treatment after LVAD implantation is feasible, and severe complications are uncommon.
Free Software and Physician Profiling—Reply
Authors: Robert Hogan
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serendipity in Clinical Investigation
Authors: John Eager Howard
Journal: JAMA (1969)

Serendipity is one of my favorite words. Not only is it euphonious but its meaning carries overtones and innuendos of precise yet ephemeral nature, as so many French words do, and so few do in our own language. The word was invented by Horace Walpole; but, with its wide popularity, the original meaning has often been corrupted to signify everything from accidental discovery to<i>serene stupidity</i>. Walpole's letter to Horace Mann on the derivation of the word and its meaning makes delightful reading, and I shall quote some excerpts: Serendipity, a very expressive word, which, as I have nothing better to tell you in this letter, I shall endeavor to explain to you; you will understand it better by the derivation than by the definition. I once read a silly fairy tale, called the Three Princes of Serendip: as their hignesses travelled, they were always making discoveries, by accidents and
Humors of Tumors: Potential for Interaction Between Cancer Type and Treating Oncologist's Personality?
Authors: Craig P. Carden, Ian R. Judson
Journal: Journal of Clinical Oncology (2008)

between the vascular endothelial growth factor (VEGF) and ER pathways. 3 Estrogen receptors are expressed in the majority (61% to 79%) of ovarian cancers, with endometrioid and serous types having the highest ER expression. 4 There is precedence for the use of antiestrogen therapy in ovarian cancer but, unfortunately, most studies have not considered ER status of the tumor.In an earlier study that did, tamoxifen (40 mg/d) demonstrated an 18% response rate in 105 patients.Of the nine patients who had a complete response, eight patients (89%) had tumors that were ER-positive. 5 In a more recent study of 42 patients with ER-positive ovarian cancers, the nonsteroidal aromatase inhibitor, letrozole, produced a response in nine patients (17%). 6 Therefore, if disrupting a pathway, such as VEGF, is desirable in tumors with an intact ER pathway, as seen in breast and ovarian cancers, simultaneously blocking its crosstalk partner, ER, may be even more desirable.In that regard, estradiol can induce hypoxiainducible factor 1-␣ (HIF-1␣) and its downstream target gene, VEGF-A, in ovarian tumor cells. 7 Estradiol would be targeted by the antiestrogen and VEGF by bevacizumab, for dual inhibition of the two cross-talking pathways, a relatively less costly regimen.If vascular occlusion is a concern, since both tamoxifen and bevacizumab have such an association, perhaps one of the multitargeting tyrosine kinase inhibitors could be used as the VEGFR blocking agent in place of the latter.These oral agents do not appear to have such adverse effects and would give a completely oral regimen.