tbuckley/cabot-search huggingface dataset:
838. 10 Year Follow-Up of 146 Advanced Stage NSCLC Patients Who Received Adenoviral Based Therapy
Authors: John Nemunaitis, Been Pappen, Rosemarie Arzaga, Casey Cunningham, Neil Senzer
Journal: Molecular Therapy (2006)

We report the first long-term follow-up of adenoviral vector based therapeutics patients who previously received anticancer therapy. Over the period of 10/26/95 to 8/15/05 146 patients with stage IIIB/ IV NSCLC were treated as out patients. Patients participated in 1 of 8 adenoviral based therapeutic trials involving 6 different agents. All were evaluable for long term unexpected toxic effect and survival. The study agent and number of patients is as follows: Bystander GVAX, 35; GVAX, 53; Adenoviral p53, 51; Onyx 015, 5; TNFeride, 1; MDA7, 1. Early safety and activity results have previously been reported in the literature(see below). Male/female ratio was 55%/45%, and median age was 60 years (19–85 years). No long term unexpected toxicity was reported. Overall mean survival was 334 days (95% CI: 269 to 400), median survival was 199 (95% CI: 168 to 320) days. No difference in survival was demonstrated by gender (Log Rank, p = 0.187) or age (Log Rank, p = 0.392). Survival at 1 year and at 2 years for patients <60 years and > 60 years respectively was 32% and 16% vs. 27% and 5%. These results are consistent with expected survival described in the literature of similar advanced stage NSCLC patients over the same time period and suggest no evidence of long term adverse effect related to adenoviral vector therapy. Four patients remain alive more than 3 years after treatment. 1.Nemunaitis J, Jahan T, Ross H, et al. Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX® vaccine in advanced-stage non-small-cell lung cancer. Cancer Gene Therapy 2006 Jan 6; [epub ahead of print]. 2.Cunningham CC, Chada S, Merritt J, et al: Clinical and Local Biological Effects of an Intratumoral Injection of mda-7 (INGN 241) in Patients with Advanced Carcinoma; a Phase I Study. Molecular Therapy 2005 Jan; 11(1):149–59. 3.Nemunaitis J, Sternman D, Juhn K, et al. Phase I/II Study of GMCSF Gene- Modified Autologous Tumor Vaccine (GVAX) in Early and Advanced Stage Non Small Cell Lung Cancer. Journal of the National Cancer Institute 2004; 96: 326–331. 4.Senzer N, Mani S, Rosemurgy A, et al. TNFerade Biologic, an Adenovector with a radiation- inducible promoter, carrying the Human Tumor Necrosis Factor Alpha Gene: A phase I study in Patients with Solid Tumors. Journal of Clinical Oncology 2004 Feb; 22(4):592–601. 5.Nemunaitis J, Cunningham C, Buchanan A, et al: Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: Safety, feasibility and biological activity. Gene Therapy 8(10):746–59, 2001 May. 6.Nemunaitis J, Swisher G, Timmons T, et al: Adenovirus-mediated p53 gene transfer in sequence with Cisplatin to tumors of patients with non-small cell lung cancer. Journal of Clinical Oncology 18(3):609–622, 2000. 7.Swisher SG, Roth JA, Nemunaitis J, et al. Adenoviral-mediated p53 gene transfer in advanced non-small cell lung cancer. J Natl Cancer Inst 91(9):763–771, 1999. May.
"Failed back surgery syndrome"
Authors: L. Talbot
Journal: BMJ (2003)

An inappropriate diagnostic label may exacerbate the discomfort of patients who develop persistent and disabling symptoms after back surgery

Every general practitioner has one–a patient who has had back surgery but hasn't improved. Around 2000 cases of failed back surgery syndrome are produced each year in the United Kingdom.1–3 This is an uncomfortable statistic, and it is an uncomfortable condition to manage. Patients are often young and were previously active but now face chronic pain for years. They come from the surgeons but are no longer surgical candidates. They have been through the gamut of orthopaedic, neurological, and radiological opinions followed by physiotherapy, occupational therapy, and possibly clinical psychology, funnelling them inexorably towards the pain clinic. Unfortunately, they fare badly there too, with just over one in three patients achieving more than 30% pain relief.

I know about this dreary path at first hand. Nowadays, we may increasingly be questioning the advisability of surgery for prolapsed disc, but not operating can also produce long term disability. Comparison of the UK rate of spinal surgery with that in other …
Improving the management of chronic disease
Authors: R. Smith
Journal: BMJ (2003)

The NHS is trying out a new system of caring for people with chronic disease, designed to prevent hospital admission. Professor Robert Kane evaluated an American version of the system 

“In effect, we're practising 19th century medicine in the 21st century,” said Robert Kane, professor in long term care and ageing at the University of Minnesota, with emotion, even anger, when I spoke to him recently. “Most health care is concerned with patients with chronic disease, particularly as they age, and yet we still have a system built around individual care events, like office visits and hospital admissions. The epidemiology is out of synch with the system. We need chronic disease management.”

Why hasn't the system changed? “In the United States,” answers Kane, “health care is 15% of the economy. There are too many vested interests. Doctors are conservative and their teachers are even more conservative. Then there's no consumer demand for change.”

Kane's interest in improving systems of care began when he did some research in nursing homes in the 1970s, when he was working at the University of Utah. One of his colleagues, the professor of family medicine …
Catheter positions in congenital cardiac malformations.
Authors: R M Taketa, D J Sahn, A L Simon, S J Pappelbaum, W F Friedman
Journal: Circulation (1975)

Biplane cineangiocardiograms were examined from a population of patients with diverse forms of congenital heart disease and examples were selected to illustrate catheter positions which may help define and elucidate the anatomy of simple and complex cardiac lesions. Familiarity with the appearance of these typical and atypical catheter positions may be of considerable aid in the course of hemodynamic study and in the evaluation of cineangiocardiograms. The editors suggest that each figure be evaluated as an unknown before reading the caption.
Textbook of Pediatric Emergency Medicine
Authors: Marc S. Nelson
Journal: JAMA (1994)

With the publication of the third edition of their textbook in pediatric emergency medicine, editors Gary Fleisher and Stephen Ludwig have created the most comprehensive book to date for health care providers who manage pediatric emergencies. This very excellent textbook was significantly expanded and improved since their last edition in 1988. There are new chapters on prehospital care and pediatric interhospital transport. The latter is a particularly useful addition, as more and more children are being transferred to tertiary care facilities where they can benefit from the specialty services (medical, nursing, rehabilitation, and so forth) those hospitals provide. Many are victims of trauma, which remains the leading cause of death for children over the age of 1 year. Unlike the previous edition, which included trauma in the section on surgical emergencies, this new edition has a separate section on trauma, making it easier to access information and, perhaps more significantly,
THE STATUS OF DRUGLESS HEALERS IN THE UNITED STATES
Authors: JOHN R. NEAL
Journal: JAMA (1941)

With the world aflame with the spirit of war it may seem of little moment and of minor concern to discuss such a prosaic subject as the status of drugless healers in the United States. Past experience, however, suggests that it is during times when international affairs absorb public interest and thought or in times of national stress when public attention is focused on large specific problems of economics or on general governmental matters that successful efforts are frequently made to break down the legal and other conventional barriers which protect a civilized society from ill conceived and unpractical reforms. That drugless healers recognize the psychologic advantages of seeking favor in times of general stress or in periods of governmental transition and are alert to put forward energetic efforts to gain ground under such circumstances was well illustrated in Illinois recently. On the death of the governor, the lieutenant governor
Abstract S4-1: FinXX Final 5-Year Analysis: Results of the Randomised, Open-Label, Phase III Trial in Medium-to-High Risk Early Breast Cancer
Authors: H Joensuu, P-L Kellokumpu-Lehtinen, R Huovinen, A Jukkola-Vuorinen, M Tanner, R Kokko, J Ahlgren, P Auvinen, P Bono, H Lindman
Journal: Cancer Research (2010)

Abstract Background: The randomised, phase III FinXX trial (NCT00114816) investigated whether the integration of capecitabine (X) into a sequential docetaxel (T)→cyclophosphamide + epirubicin + 5-FU (CEF) adjuvant regimen might improve clinical outcome for patients with medium-to-high risk early breast cancer. The planned interim analysis after a median follow-up of 3 years found a significant recurrence-free survival (RFS) benefit with the X-containing regimen versus control (3-year RFS rate: 93% XTP→ukkalaCEX vs 89% T→CEF; hazard ratio 0.66 [95% CI: 0.47-0.94]; p=0.020) [Lancet Oncol 2009;10:1145-51]. Here we present final 5-year RFS data, the primary endpoint of the study. Methods: Eligible patients were aged 18-65 years, had a WHO performance status of 0 or 1 and histologically confirmed invasive breast cancer at medium-to-high risk of recurrence, defined as regional node-positive disease or node-negative disease with primary tumour diameter greater than 20mm and negative progesterone receptor assay. Previous neoadjuvant chemotherapy was not permitted. Patients were randomised in a 1:1 ratio to receive 3 cycles of T→3 cycles of CEF (T→CEF; T 80mg/m2 d1, q3w→C 600mg/m2 d1, E 75mg/m2 d1, F 600mg/m2 d1, q3w) or 3 cycles of XT→3 cycles of CEX (XT→CEX; X 900mg/m2 bid d1-15 + T 60mg/m2 d1, q3w→C 600mg/m2 d1, E 75mg/m2 d1, X 900mg/m2 bid d1-15, q3w). The primary endpoint was RFS, defined as the time from randomisation to the first time the patient is recorded as having disease recurrence or the date of death if the patient dies due to causes other than disease recurrence; secondary endpoints were overall survival and safety. Results: Between January 2004 and May 2007, 1,500 women from Finland and Sweden were randomised to T→CEF (n=747) or XT→CEX (n=753). Final analysis of the primary endpoint will be presented after a median follow-up of 5 years and approximately 200 events. Data are expected in October 2010. Conclusions: The FinXX trial was the first to report the efficacy and safety of X in combination with anthracycline/taxane-containing therapy in the adjuvant treatment of early breast cancer. Final efficacy data are expected in October 2010. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr S4-1.
Torsion Ballistocardiography: With Special Reference to Patterns in Surgically Amenable Cardiovascular Diseases
Authors: KURT R. REISSMANN, E. GREY DIMOND
Journal: Circulation (1953)

The recoil forces generated in the circulatory system were converted into a momentum (torque) by using a table supported by a single steel bar in its center. With such a torsion ballistocardiograph, information can be obtained on the site of origin of the forces and on their direction, because the amplitude of the table is proportional to the product force times lever arm (distance from the center of rotation), and the latter can be varied by placing the subject in various positions relative to the center of rotation. The limitations of ballistocardiography in general arise mainly from the complexity of the system of three oscillators (heart, body, table) in which the elastic and damping properties of the body are presently unknown. These limitations are discussed.
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
Authors: Jodi Meyerowitz, Sarah J Parker, Laura J Vella, Dominic CH Ng, Katherine A Price, Jeffrey R Liddell, Aphrodite Caragounis, Qiao-Xin Li, Colin L Masters, Takashi Nonaka, Masato Hasegawa, Marie A Bogoyevitch, Katja M Kanninen, Peter J Crouch, Anthony R White
Journal: Molecular Neurodegeneration (2011)

TDP-43 proteinopathies are characterized by loss of nuclear TDP-43 expression and formation of C-terminal TDP-43 fragmentation and accumulation in the cytoplasm. Recent studies have shown that TDP-43 can accumulate in RNA stress granules (SGs) in response to cell stresses and this could be associated with subsequent formation of TDP-43 ubiquinated protein aggregates. However, the initial mechanisms controlling endogenous TDP-43 accumulation in SGs during chronic disease are not understood. In this study we investigated the mechanism of TDP-43 processing and accumulation in SGs in SH-SY5Y neuronal-like cells exposed to chronic oxidative stress. Cell cultures were treated overnight with the mitochondrial inhibitor paraquat and examined for TDP-43 and SG processing.We found that mild stress induced by paraquat led to formation of TDP-43 and HuR-positive SGs, a proportion of which were ubiquitinated. The co-localization of TDP-43 with SGs could be fully prevented by inhibition of c-Jun N-terminal kinase (JNK). JNK inhibition did not prevent formation of HuR-positive SGs and did not prevent diffuse TDP-43 accumulation in the cytosol. In contrast, ERK or p38 inhibition prevented formation of both TDP-43 and HuR-positive SGs. JNK inhibition also inhibited TDP-43 SG localization in cells acutely treated with sodium arsenite and reduced the number of aggregates per cell in cultures transfected with C-terminal TDP-43 162-414 and 219-414 constructs.Our studies are the first to demonstrate a critical role for kinase control of TDP-43 accumulation in SGs and may have important implications for development of treatments for FTD and ALS, targeting cell signal pathway control of TDP-43 aggregation.
605 SYSTEMATIC PSYCHIATRIC INTERVENTION IN CHRONIC HEPATITIS C PATIENTS TREATED BY PEG- INTERFERON A2B AND RIBAVIRIN: RANDOMIZED MULTICENTER PROSPECTIVE STUDY
Authors: C. Guillemard, C. Cognard, A.-L. Bretagne, S. Elfadel, C. Even, É. Beaujard, T. Collet, L. Lion, J.-P. Toudic, D. Cohen, I. Ollivier-Hourmand, F. Chastang, T. Dao
Journal: Journal of Hepatology (2009)
Principles of Biliary Lithotripsy. Edited by Alexander S. Cass and Leroy H. Stahlgren, 104 pp. Mount Kisco, New York: Futura Publishing Co., 1989. $25.00
Authors: Richard E. Hernandez
Journal: Hepatology (1990)

HepatologyVolume 11, Issue 6 p. 1093-1094 Book ReviewFree Access Principles of biliary lithotripsy. Edited by Alexander S. Cass and Leroy H. Stahlgren, 104 pp. Mount Kisco, New York: Futura Publishing Co., 1989. $25.00 Richard E. Hernandez M.D., Richard E. Hernandez M.D. Tulane University School of Medicine New Orleans, Louisiana 70112Search for more papers by this author Richard E. Hernandez M.D., Richard E. Hernandez M.D. Tulane University School of Medicine New Orleans, Louisiana 70112Search for more papers by this author First published: June 1990 https://doi.org/10.1002/hep.1840110635AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume11, Issue6June 1990Pages 1093-1094 RelatedInformation
Drug-Induced Blood Dyscrasias
Authors: Charles M. Huguley
Journal: JAMA (1964)

GRANULOCYTOPENIA is the most common hematological adverse reaction to drugs. If infection develops as a result of severe neutropenia (agranulocytosis), the mortality rate is 20% to 50% even with early and appropriate treatment. Only a few drugs are likely to produce this reaction, but these few do so often enough to demand caution in their use. By appropriate observation of patients receiving these drugs, agranulocytosis can be readily recognized and the number of deaths greatly reduced. The drugs most frequently associated with the development of agranulocytosis are listed in the Table. The<i>mechanism</i>by which drugs produce agranulocytosis is not known. In many instances of agranulocytosis associated with the administration of aminopyrine or sulfonamides, it has been possible to demonstrate antibodies in the patient's serum; these antibodies agglutinate leukbcytes in the presence of the drug. In cases of agranulocytosis associated with other drugs, such as the phenothiazines and the antithyroid
Abstract A25: Array-based comparative genomic hybridization of hepatocellular carcinoma reveals a unique genomic aberration pattern in tumors with poor prognosis
Authors: Stephanie Roessler, Lori Long, Anuradha Budhu, Yidong Chen, Xuelian Zhao, Robert Walker, Hu-Liang Jia, Qing-Hai Ye, Lun-Xiu Qin, Zhao-You Tang, Kent Hunter, Snorri Thorgeirsson, Paul Meltzer, Xin Wang
Journal: Cancer Research (2009)

Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Like most solid tumors, HCC is very heterogenous in its clinical presentation and genetic makeup, due to genomic instability. The poor survival of HCC patients is partly due to inefficient treatment regimens and the lack of accurate prognostic subgroup stratifications. The discovery of genomic changes in other cancer types has led to the development of novel specific therapies, underscoring the importance of understanding molecular mechanism and tumor biology to provide the best therapy for each cancer patient. To this end, we performed high-resolution array-based comparative genomic hybridization of 76 HCC clinical specimens (cohort1) to search for genetically disrupted genes associated with outcome. In agreement with previous publications, recurrent gains and losses were associated with 1q, 6p, 8q and 4q, 8p, 13q, 16, 17p, respectively. However, only deletions of a few distinct loci on 1p,4q, 8p and 9p were associated with survival (FDR&amp;lt;0.05). Of the 419 genes which mapped to regions of loss, analysis of cohort1 revealed that gene expression and DNA copy number of 134 genes (31.98%) were significantly correlated (Pearson coefficient r&amp;gt;0.3, p&amp;lt;0.001). Next, we built a 10-gene-survival signature based on the expression of these 134 genes utilizing cohort1 as a training and testing set with validation in an independent cohort2 (N=180). Kaplan-Meier survival analysis revealed that the 10-gene signature was able to predict survival outcome in tumor tissue (log-rank p=0.008) but not in paired non-tumor samples of cohort2 (log-rank p=0.421). Cox proportional hazards regression analysis controlling for potentially confounding clinical covariates showed that the 10-gene signature was significantly associated with a 2.1-fold increased risk of death. In addition, the 10-gene signature was able to predict survival in three publicly available breast cancer cohorts. In this study, we found a 10-gene signature that allows for the stratification of patients with poor prognosis in HCC and breast cancer. Ongoing functional analysis of the genes in this signature may lead to the discovery of HCC subtype-specific drugs that might be used for personalized therapy. Citation Information: Cancer Res 2009;69(23 Suppl):A25.
Treatment Without Consent: Law, Psychiatry and the Treatment of Mentally Disordered People Since 1845
Authors: U. Schuklenk
Journal: BMJ (1996)

Phil Fennell Routledge, £50, pp 356 ISBN 0 415 07787 7

Nearly 50 years after the Nuremberg Code set modern rules for ethical standards in medical research and practice, the issue of how to treat mentally disordered people in an ethically acceptable manner still causes controversy. Phil Fennell's book provides an excellent overview of the history of treatment without consent and the importance attached to first person voluntary informed consent in medical practice. It describes how drugs have replaced mechanical restraint, with the notable exception of electroconvulsive therapy. Not coincidentally perhaps, Fennell …
“Through a Glass Darkly”: Researcher Ethnocentrism and the Demonization of Research Participants
Authors: John A. Lynch
Journal: The American Journal of Bioethics (2011)

“I am a man / More sinn’d against than sinning.”—King Lear, Act 3, Scene 2, lines 59–60 In Shakespeare's play, Lear rails against his daughters who have abandoned him and asks the gods for vengeanc...
Blood Flow, Needle Size and Hemolysis — Examining an Old Wives' Tale
Authors: Gerald Moss, Charles Staunton
Journal: New England Journal of Medicine (1970)

TO avoid hemolysis during blood sampling, the admonition has been, "Use a larger bore needle." Theoretically, experimentally and in our clinical experience, the reverse is true. To test this hypothesis, an experimental determination of the relation between needle size and hemolysis was performed.MethodsThe blood to be examined was drawn from a dog whose stable, circulating red cells were "tagged" with 51Cr (25,000 to 100,000 cpm per milliliter) as previously described.† Hemolysis was calculated from the appearance of the radioactive label in the serum or plasma.The external jugular vein was catheterized under anesthesia with 5 cm (2 in) . . .
Clinical and pathological heterogeneity in cutaneous gamma-delta T-cell lymphoma: a report of three cases and a review of the literature
Authors: S.E. MUNN, J.M. McGREGOR, A. JONES, P. AMLOT, M.H.A. RUSTIN, R. RUSSELL JONES, S. WHITTAKER
Journal: British Journal of Dermatology (1996)

Cutaneous gamma-delta (γδ) T-cell lympboma is rare. Eleven cases have been reported to date including four cases of mycosis fungoides (MF). two of pagetoid reticulosis and five of pleomorphic cutaneous T-cell lymphoma (CTCL). We report three further cases of cutaneous γδ T-cell lymphoma: one of ME. one of a pleomorpbic CTCL and one of a subcutaneous T-cell iymphoma. Combined data suggest that although cutaneous γδ T-cell iymphomas do not appear to comprise a single clinicopathoiogical entity, they may be associated with aggressive clinical behaviour and a poor prognosis.
Dipolar Electrode in Heart Block
Authors: I. Richard Zucker
Journal: JAMA (1963)

It was determined that employment of the Newark Beth Israel Hospital (NBIH) intracardiac dipolar electrode for temporary cardiac pacing in preparation of patients for permanent pacemaker implantation or other operation is a dependable and easily performed procedure. The dipolar electrode was found most effective when positioned at any site in the right ventricle where the lowest driving voltage is required. Endocardial contact was not necessary. The optimal distance between electrodes was 1 cm or less, the need thus being obviated for an external indifferent electrode. Endocardial or myocardial damage was not demonstrated. Subsequent major operation was uneventful when cardiac rate and rhythmicity were controlled. Confidence of the patient was markedly improved. Poor-risk patients were well supported. Patients were ambulatory. Formation of clot on the positive pole of a tripolar or coaxial catheter was not demonstrated in animals.