Successful Treatment of Hypoglycemia Using Glucagon in a Patient with an Extrapancreatic Tumor
Authors: Naguib A. Samaan
Journal: Annals of Internal Medicine (1990)

Brief Reports1 September 1990Successful Treatment of Hypoglycemia Using Glucagon in a Patient with an Extrapancreatic TumorNaguib A. Samaan, MD, PhD, Frank K. Pham, BS, Rena V. Sellin, MD, Jose F. Fernandez, MD, Robert S. Benjamin, MDNaguib A. Samaan, MD, PhDSearch for more papers by this author, Frank K. Pham, BSSearch for more papers by this author, Rena V. Sellin, MDSearch for more papers by this author, Jose F. Fernandez, MDSearch for more papers by this author, Robert S. Benjamin, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-5-404 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe mechanism of hypoglycemia in extrapancreatic tumors remains controversial, and no treatment has been established. Some investigators have suggested that the hypoglycemia may, in part, be the result of growth-hormone deficiency and, if so, that treatment with growth hormone might be beneficial (1-3). This theory, however, has not been tested. We recently had the opportunity to evaluate both the mechanism of and the treatment options for hypoglycemia in a patient with a severe case resulting in meningeal sarcoma with retroperitoneal and liver metastases. We found that although growth-hormone deficiency was present, growth-hormone treatment was not effective; continuous intravenous glucagon administration,...References1. DaughadayEmanueleBrooksBarbatoKapadiaRotwein WMMAMP. Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. N Engl J Med. 1988;319:1434-6. CrossrefMedlineGoogle Scholar2. AxelrodRon LD. Insulin-like growth factor II and the riddle of tumor-induced hypoglycemia. N Engl J Med. 1988;319:1477-9. CrossrefMedlineGoogle Scholar3. RonPowersPandianGodineAxelrod DAMJL. Increased insulin-like growth factor II production and consequent suppression of growth hormone secretion: a dual mechanism for tumor-induced hypoglycemia. J Clin Endocrinol Metab. 1989;68:701-6. CrossrefMedlineGoogle Scholar4. FurlanettoUnderwoodVan WykHandwerger RLJS. Serum immunoreactive somatomedin-C is elevated in late pregnancy. J Clin Endocrinol Metab. 1980;47:695-8. CrossrefGoogle Scholar5. DavenportSvobodaKoerberVan WykClemmons MMKJD Underwood LE. Serum concentrations of IGF 2 are not changed by short term fasting and refeeding. J Clin Endocrinol Metab. 1988; 67:1231-6. CrossrefMedlineGoogle Scholar6. DaughadayParkerBorowskyTrivediKapadia WKSBM. Measurement of s'omatomedin-related peptides in fetal, neonatal, and maternal rat serum by insulin-like growth factor (IGF)-I radioimmunoassay activity RRA after acid-ethanol extraction. Endocrinology. 1982;110:575-81. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University of Texas M. D. Anderson Cancer Center, Houston, Texas. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRefractory Hypoglycemia Controlled by Sorafenib in Solitary Fibrous TumorIntensive Care of the Cancer PatientDiagnosis and Management of Nonislet Cell Tumor HypoglycemiaParaneoplastic Syndromes: Elements of Interest for the UrologistMetabolic Emergencies in OncologyMalignant insulinomaReproduction of Features of the Glucagonoma Syndrome with Continuous Intravenous Glucagon Infusion as Therapy for Tumor-Induced HypoglycemiaEndocrinology and systemic diseaseDifficult InsulinomaHepatic and pulmonary metastases from a meningeal hemangiopericytoma and severe hypoglycemia due to abnormal secretion of insulin-like growth factorTumor Hypoglycemia Linked to IGF-IIGlucocorticoid therapy suppresses abnormal secretion of big IGF-II by non-islet cell tumours inducing hypoglycaemia (NICTH)Hepatoma With Severe Non-Islet Cell Tumor HypoglycemiaThe role of glucagon administration in the diagnosis and treatment of patients with tumor hypoglycemiaTumour-induced hypoglycaemia: A case reportNon-islet-cell tumor associated with hypoglycemia in a child: Successful long-term therapy with growth hormoneInsulinlike growth factor binding proteins and tumor hypoglycemiaPrevention with glucocorticoids of extrapancreatic tumour-hypoglycaemia as a result of increased ‘big’ insulin-like growth factor IIIslet Cell Tumors of the PancreasTumour-induced hypoglycaemia: A case reportInsulin-like growth factors and non-islet cell tumor hypoglycemiaHypoglycaemia in the adultAlleviation of Non-Islet Cell Tumour Hypoglycaemia by Growth Hormone Therapy is Associated with Changes in IGF Binding Protein-3Tumor Secretion of Growth FactorsTumours producing hypoglycaemia 1 September 1990Volume 113, Issue 5Page: 404-406KeywordsCancer treatmentEndocrinologyGlucagonGrowth hormoneHypoglycemiaLiverSarcoma Issue Published: 1 September 1990 PDF DownloadLoading ...