tbuckley/cabot-search huggingface dataset:
Bertram W. Sippy and Ulcer Disease Therapy
Authors: Geoffrey M. Zucker
Journal: JAMA (1983)

This issue ofThe Journalreprints Bertram W. Sippy's article on "Gastric and Duodenal Ulcer: Medical Cure by an Efficient Removal of Gastric Juice Corrosion." That such commemoration is appropriate can be appreciated only when Sippy's role in the history of peptic ulcer disease is recognized. From our present perspective, it is hard to imagine the confusion and conflict surrounding the etiology, pathogenesis, and treatment of ulcers that existed at the end of the 19th century. Both in America and Europe, differing theories existed as to the nature of the illness and its treatment. Sippy's report was the culmination of years of observation and clinical practice, and by virtue of the force of his personality, his perseverance, and the correctness of his therapy, his name is remembered to this day. <h3>Brief History of Ulcer Disease</h3> The historical beginnings of the understanding of ulcer of the stomach and duodenum are obscured
Restoration of normal coronary hemodynamics and myocardial metabolism after percutaneous transluminal coronary angioplasty.
Authors: D O Williams, R S Riley, A K Singh, A S Most
Journal: Circulation (1980)

Regional coronary blood flow and myocardial metabolism were evaluated in a patient who underwent percutaneous transluminal coronary angioplasty (PTCA). Angioplasty increased coronary luminal diameter and reduced trans-stenotic gradient. Before PTCA, angina pectoris developed during sustained rapid atrial pacing and was associated with abnormal lactate metabolism and a mild increase in coronary flow and myocardial oxygen consumption. After PTCA, angina was absent during pacing and lactate extraction was preserved. Coronary flow and oxygen consumption were increased to a greater degree than before PTCA. The temporal response of changes in coronary blood flow due to an abrupt increase in heart rate was also evaluated. Floow reached peak value more rapidly after PTCA. These observations suggest that PTCA may result in improved regional coronary blood flow and restoration of normal flow regulatory mechanism and myocardial metabolism.
Abstract 2383: MicroRNA-519c suppresses HIF-1α expression and tumor angiogenesis
Authors: Shih-Ting Cha, Pai-Sheng Chen
Journal: Cancer Research (2010)

Abstract Hypoxia-inducible factor (HIF)-1α is widely considered to be one of the key regulators of tumor angiogenesis. The upstream regulation is complex and involves several growth factors, cytokines and hypoxia. Herein, we identified miR-519c as a hypoxia independent regulator of HIF-1α, acting through direct binding to HIF-1α 3′UTR and leading to reduced tumor angiogenesis. Over expression of miR-519c resulted in a significant decrease of HIF-1α protein levels and reduced the tube formation of HUVEC cells and similarly, antagomir inhibition of miR-519c increased the level of HIF-1α protein and enhanced angiogenic activity, suggesting an important role of miR-519c in HIF-1α-mediated angiogenesis. In consistence with the over-expression of miR-519c in cancer patients with better prognosis, mice injected with miR-519c over-expressing cells exhibited dramatically reduced HIF-1α level, followed by suppressed tumor angiogenesis, growth, and metastasis. In addition, we found that hepatocyte growth factor (HGF), a known HIF-1α inducer, reduced miR-519c levels in an Akt-dependent pathway. This regulation is post-transcriptional and may mediate by suppressing miR-519c maturation. Taken together, our findings provide the first evidence that miR-519c is a pivotal regulator of tumor angiogenesis and, moreover, micro environmental HGF contributes to regulating miR-519c biogenesis in cancer cells. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2383.
Predictors of Restenosis After Coronary Stent Implantation
Authors: Christophe Bauters, Edouard Hubert, Alain Prat, Karim Bougrimi, Eric Van Belle, Eugène P McFadden, Philippe Amouyel, Jean-Marc Lablanche, Michel Bertrand
Journal: Journal of the American College of Cardiology (1998)
Commentary: Summary statistics of poor quality studies must be treated cautiously
Authors: J. A Berlin
Journal: BMJ (1997)

Objective: To evaluate the immunogenicity and reactogenicity of a new triple S recombinant hepatitis B vaccine in a cohort of healthy people in whom currently licensed hepatitis B vaccines had persistently not induced an immune response.Design: Single centre, randomised, double blind, dose-response study.Setting: Research vaccine evaluation centre at a teaching hospital.Subjects: 100 healthcare workers aged 18-70 years with a history of failure to seroconvert after at least four doses of a licensed hepatitis B vaccine containing the S component.Intervention: Each subject was randomly allocated two doses of 5, 10, 20, or 40 g of a new hepatitis B vaccine two months apart.Main outcome measures: Immunogenicity of the four doses.Seroconversion and seroprotection were defined as an antibody titre > 10 IU/l and > 100 IU/l respectively against an international antibody standard.Results: 69 subjects seroconverted after a single dose of the vaccine.After the booster vaccination one other subject seroconverted, bringing the overall seroconversion rate to 70%.Fifteen subjects given 5 g of vaccine, 19 given 10 g, 16 given 20 g, and 20 given 40 g seroconverted.Seroconversion rates in the four antigen dose groups were 60% (15/25), 76% (19/25), 64% (16/25), and 80% (20/25).After the booster dose there was no significant dose-response effect on the overall seroconversion rate, although the small sample size meant that a clinically important dose-response could not be ruled out. Conclusion:A single dose of 20 g of the vaccine was as effective as two doses of either 40 g or 20 g of this vaccine formulation in terms of seroconversion, seroprotection, and geometric mean titres.
68Ga-DOTATATE-PET/CT Positive Metastatic Lymph Node in a 69-Year-Old Woman With Merkel Cell Carcinoma
Authors: Christina Schneider, Max Schlaak, Marc Bludau, Birgid Markiefka, Matthias C. Schmidt
Journal: Clinical Nuclear Medicine (2012)

We report the case of a 69-year-old woman with a Merkel cell carcinoma (MCC) in whom subsequent lymph node metastasis was first diagnosed by 68Ga-Dotatate-PET/CT followed by histopathological confirmation. MCC is an extraordinarily rare and aggressive neuroendocrine tumor of dermal origin with a high rate of postoperative recurrence. Owing to its rarity, the diagnosis of MCC remains a significant challenge. In our case, 68Ga-Dotatate-PET/CT proved clinically useful for diagnosing the lymph node metastasis of a MCC.
Radiographic changes in early rheumatoid disease.
Authors: A Brook, M Corbett
Journal: Annals of the Rheumatic Diseases (1977)

We have studied the radiological features in 94 patients with early rheumatoid disease followed prospectively for 5 years. The changes appeared very early and occurred in up to 71-3% of patients. Erosive changes occurred in the feet much more commonly than in the hands and considerably earlier. Erosive changes were present before there was joint-space loss. Frequent x-ray examination of feet and hands in the first 2 years after presentation is required if we are to identify patients at risk for serious joint damage.
Anticonvulsant effects of leptin in epilepsy
Authors: Sabrina Diano, Tamas L. Horvath
Journal: Journal of Clinical Investigation (2007)

Secreted from adipose tissue at levels proportional to fat stores, the hormone leptin is a critical regulator of the hypothalamic machinery that controls feeding and energy metabolism. Despite the critical role of leptin in the maintenance of energy homeostasis, no leptin-based therapeutic approaches have emerged to combat metabolic disorders such as obesity or diabetes. In this issue of the JCI, Xu et al. report a robust influence of leptin, beyond its role in metabolism, on hippocampal neuronal processes implicated in the etiology of epileptic seizures, learning, and memory (see the related article beginning on page 272). They show, in two rodent seizure models, that leptin administered directly to the brain or nasal epithelium suppresses seizures via direct effects on glutamate neurotransmission in the hippocampus. These observations suggest that leptin may have therapeutic potential in the treatment of epilepsy and strengthen the notion that peripheral metabolic hormones such as leptin play important roles in the regulation of higher brain functions.
The Evolution of Trial Registries and Their Use to Assess the Clinical Trial Enterprise
Authors: Kay Dickersin, Drummond Rennie
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanisms of the Fasting-Induced Increase in Insulin Binding to Rat Adipocytes
Authors: Jerrold M. Olefsky, Masashi Kobayashi
Journal: Journal of Clinical Investigation (1978)

Fasting leads to an increase in the ability of adipocytes to bind insulin, and this was accounted for by an increase in the affinity of the receptors for insulin without any change in the number of receptors per cell. Binding affinity can increase because of a decrease in the dissociation rate constant (k(d)), an increase in the association rate constant (k(a)), or both. Kinetic studies demonstrated that fasting leads to a striking decrease in the rate at which insulin dissociates from its receptor, and the near two-fold prolongation of the time at which 50% of the bound (125)I-insulin dissociates (28+/-4 vs. 50+/-5 min) correlated quite well with the two-fold increase in binding affinity. On the other hand, the rate at which insulin associates with its receptor was essentially unchanged. Negatively cooperative interactions between receptors were readily demonstrated in cells from control and fasting animals, and the magnitude and sensitivity of this effect was the same in both groups of cells. It seemed likely that during fasting a change in the concentration of some substrate or hormone could lead to these effects on insulin binding. However, in vitro attempts to recreate the substrate and hormonal changes which occur in fasting produced no evidence to support this idea.(a) fasting leads to an increase in the ability of adipocytes to bind insulin because of an increase in binding affinity; (b) this increase in the affinity of the receptor for insulin was primarily accounted for by a decrease in the rate at which insulin dissociates from its receptors; and (c) fasting did not appreciably alter the negatively cooperative interactions displayed by adipocyte insulin receptors.
Detrended fluctuation analysis of genome-wide copy number profiles of glioblastomas using array-based comparative genomic hybridization
Authors: Yukiko Nakahara, Tetsuya Shiraishi, Hiroaki Okamoto, Toshihiro Mineta, Tsuyoshi Oishi, Kohsuke Sasaki, Kazuo Tabuchi
Journal: Neuro-Oncology (2004)

We examined whole genomic aberrations of biopsied samples from 19 independent glioblastomas by array-based comparative genomic hybridization analysis. The highest frequencies of copy number gains were observed on RFC2 (73.3%), EGFR (63.2%), and FGR, ELN, CDKN1C, FES, TOP2A, and ARSA (57.9% each). The highest frequencies of copy number losses were detected on TBR1 (52.6%), BMI1 (52.6%), EGR2 (47.4%), DMBT1 (47.4%), MTAP (42.1%), and FGFR2 (42.1%). The copy number gains of CDKN1C and INS and the copy number losses of TBR1 were significantly correlated with longer survival of patients. High-level amplifications were identified on EGFR, SAS/CDK4, PDGFRA, MDM2, and ARSA. These genes are assumed to be involved in tumorigenesis or progression of glioblastomas. The first attempts to apply detrended fluctuation analysis to copy number profiles by considering the reading direction as the time axis demonstrated that higher long-term fractal scaling exponents (α2) correlated well with longer survival of glioblastoma patients. The present study indicates that array-based comparative genomic hybridization analysis has great potential for assessment of copy number changes and altered chromosomal regions of brain tumors. Furthermore, we show that nonlinear analysis methods of whole genome copy number profiles may provide prognostic information about glioblastoma patients.
Management of Critically Ill Patients
Authors: Ata Mahmoodpoor, Samad E. J. Golzari
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Les Savants Ne Sont Pas Curieux
Authors: Charles L. Squier
Journal: JAMA (1965)

To the Editor:—  In the April 12, 1965, issue ofThe Journal(192: 94) you reprinted a sonnet by Merrill Moore (not Merril) and gave his dates as (1903-). Unfortunately, Dr. Moore, whose sonnet begins Doctors must die, too..., died in 1957. According to his own diagnosis, Dr. Moore suffered from a compulsive addiction to the sonnet and wrote from two to five a day in his sonnetorium. The quality of many of his sonnets is such that he will be remembered in the history of the sonnet in English for something more than his remarkable prolificacy.
Coronary Sinus Blood Flow in Trepopneic Angina: Case Report
Authors: R. M. MILLS
Journal: Annals of Internal Medicine (1976)

Letters1 March 1976Coronary Sinus Blood Flow in Trepopneic Angina: Case ReportR. M. MILLS, M.D., G. H. MUDGE JR., M.D., MICHAEL LESCH, M.D., F.A.C.P.R. M. MILLS, M.D., G. H. MUDGE JR., M.D., MICHAEL LESCH, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-3-295 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTrepopnea refers to the preference for a particular recumbent position and a dislike of others. In 1937, Wood and Wolferth (1) introduced the term and reported their extensive observations of trepopnea in 52 patients with heart disease, including 3 with positional angina pectoris.We have studied a patient with coronary artery disease in whom the left lateral decubitus position induced angina. Cardiac catheterization was done using a thermodilution coronary sinus blood flow catheter, thus obtaining measurements of coronary blood flow in various body positions.A 41-year-old married practical nurse, gravida 6, para 4, was referred for cardiac catheterization and coronary...References1. WOODWOLFERTH FC: The tolerance of certain cardiac patients for various recumbent positions (trepopnea). Am J Med Sci 193:354-378, 1937 CrossrefGoogle Scholar2. GANZTAMURAMARCUS WKH: Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation 64:181-195, 1971 CrossrefGoogle Scholar3. VAN DEVANTERMILLSLESCH SRM: Thennodilution measurement of coronary sinus blood flow during cardiopulmonary bypass. Surg Forum 26:225-227, 1975 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Massachusetts Medical School Worcester, Massachusetts 01605 Cardiovascular Division Peter Bent Brigham Hospital Harvard Medical School Boston, Massachusetts 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe lateral decubitus position may affect gastric emptying through an autonomic mechanism: the skin pressure-vegetative reflex [letter]Right Lateral Decubitus Position via Skin Pressure Vegetative Reflex May Prevent Anxiety, Adverse Autonomic Reactions, and Syncope in Blood DonorsForced unilateral nostril breathing: A technique that affects brain hemisphericity and autonomic activityEffects of supine and lateral positions on cardiac output and intracardiac pressures: an experimental study. 1 March 1976Volume 84, Issue 3Page: 295-296KeywordsAnginaBlood flowCardiovascular therapyCatheterizationCathetersNursesStable coronary artery disease Issue Published: 1 March 1976 PDF DownloadLoading ...
The Protective Efficacy of Haemophilus b Polysaccharide Vaccine
Authors: Eugene D. Shapiro
Journal: JAMA (1988)

To assess the protective efficacy of the<i>Haemophilus</i>b polysaccharide vaccine, a case-control study was conducted in Connecticut, Dallas County, and greater Pittsburgh. Seventy-six children 24 to 72 months of age who had<i>H influenzae</i>type b isolated from normally sterile sites from August 1985 through July 1987 were enrolled. For each case two controls, matched by age and place of residence, were randomly selected from the records of all live births in the area. Antecedent receipt of the<i>Haemophilus</i>b polysaccharide vaccine was ascertained from the records of all physicians and clinics at which the subjects received medical care. Overall, 12% of the cases and 39% of the controls had received the vaccine. The estimate of the protective efficacy of the vaccine was 88% overall (95% confidence interval, 74% to 96%) and 91% (95% confidence interval, 71% to 99%), 92% (95% confidence interval, 76% to 99%), and 81% (95% confidence interval, 45% to 96%) in Connecticut, Dallas County, and greater Pittsburgh, respectively. The estimates were not substantially affected by adjusting with logistic regression for differences between the cases and controls in race and the attendance of group day care. We conclude that the<i>Haemophilus</i>b polysaccharide vaccine is highly effective in these areas among children who receive the vaccine when they are 24 months of age or older. (<i>JAMA</i>1988;260:1419-1422)
Combined Immunodeficiencies: Clinical, Immunological Features And Outcome Of 56 Cases From A Single Institution
Authors: A. İkincioğulları, F. Doğu, C. Aytekin, F.E. Çipe, M. Yüksek, G. Bozdoğan, A. Yıldıran, D. Güloğlu, E. Babacan
Journal: Journal of Allergy and Clinical Immunology (2010)
Porphyria Precipitated by Fasting
Authors: Kermit B. Knudsen, Marshall Sparberg, Frank Lecocq
Journal: New England Journal of Medicine (1967)

A VARIETY of chemotherapeutic drugs, such as barbiturates, sulfonamides, estrogens and griseofulvin, may precipitate the acute onset of symptoms in patients with acute intermittent porphyria.1 Toxic porphyria in human beings and experimental porphyrinuria in animals have been induced by exposure to several different chemicals.1 , 2 Caloric reduction may have a profound influence on both experimental porphyrinuria and spontaneous acute intermittent porphyria in human beings. The incidence of allylisopropylacetamide-induced porphyria in rats was increased by a reduction of the carbohydrate and protein content of the diet, with a high percentage of porphyrinuria occurring during starvation.2 Welland et al.3 described increased excretion of . . .
Attenuation of γδTCR Signaling Efficiently Diverts Thymocytes to the αβ Lineage
Authors: Mariëlle C. Haks, Juliette M. Lefebvre, Jens Peter H. Lauritsen, Michael Carleton, Michele Rhodes, Toru Miyazaki, Dietmar J. Kappes, David L. Wiest
Journal: Immunity (2005)
Abstract 2803: A pooled analysis of circulating 25(OH)D and upper gastrointestinal cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
Authors: Christian C. Abnet, Yu Chen, Wong-Ho Chow, Yu-Tang Gao, Kathy J. Helzlsouer, Loic Le Marchand, Marjorie L. McCullough, James M. Shikany, Xiao-Ou Shu
Journal: Cancer Research (2010)

Abstract Upper gastrointestinal (UGI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but are uncommon in Western countries. While it is clear that vitamin D plays important roles in human health, only one prospective study has examined the association between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and risk of UGI cancers. This study examines the association in eight prospective cohort studies from China, Finland, and the USA that are part of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. 25(OH)D concentrations in serum or plasma were measured from 1065 UGI cancer cases and 1066 age-, sex-, race-, and season of blood draw-matched controls. In controls, the median (interquartile range) of circulating 25(OH)D was 39.1 (25.8-56.7) nmol/L, while in cases it was 39.4 (26.3-56.1). 25(OH)D exposure was categorized as six clinically defined categories. A meta-analytic approach showed no significant heterogeneity of effect among the included studies. In multivariate-adjusted models, circulating 25(OH)D concentration was not significantly associated with UGI cancer risk. Compared to the referent group, 50 to &amp;lt;75 nmol/l, those in the lowest (&amp;lt;25 nmol/L) or highest (&amp;gt;=100 nmol/L) categories had odds ratios (95% confidence intervals (CI)) of 0.90 (0.65-1.24) and 0.81 (0.39-1.69), respectively. Subgroup analysis by race showed that among Asians, being in the lowest category was associated with a statistically significant decreased risk of UGI cancer with odds ratio (95% CI) = 0.53 (0.31-0.91) compared to the referent group, but no association in Caucasians, odds ratio (95% CI) = 0.98 (0.67-1.44). Never smokers with concentrations &amp;lt;25 nmol/L were also at lower risk of UGI cancers with odds ratio (95% CI) = 0.55 (0.31-0.96). These results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to lower risk of these highly fatal cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2803.