tbuckley/cabot-search huggingface dataset:
Systemic and cutaneous plasmacytosis with multiple skin lesions and polyclonal hypergammaglobulinaemia: significant serum interleukin-6 levels
Authors: A. KODAMA, M. TANI, K. HORI, T. TOZUKA, T. MATSUI, M. ITO, S. NAKAO, T. FUJITA, H. KOBAYASHI
Journal: British Journal of Dermatology (1992)

Journal Article Systemic and cutaneous plasmacytosis with multiple skin lesions and polyclonal hypergammaglobulinaemia: significant serum interleukin‐6 levels Get access A. KODAMA, A. KODAMA Department of Dermatology, Kobe University School of Medicine, 5 Kusunoki‐cho, 7 chome, Chuo‐ku, Kobe 650, Japan Search for other works by this author on: Oxford Academic Google Scholar M. TANI, M. TANI Department of Dermatology, Kobe University School of Medicine, 5 Kusunoki‐cho, 7 chome, Chuo‐ku, Kobe 650, Japan Dr M. Tani Search for other works by this author on: Oxford Academic Google Scholar K. HORI, K. HORI Department of Dermatology, Kobe National Hospital, 1 Nishiochiai, 3 chome, Suma‐ku, Kobe 654, Japan Search for other works by this author on: Oxford Academic Google Scholar T. TOZUKA, T. TOZUKA Department of Internal Medicine, Kobe University School of Medicine, Japan Search for other works by this author on: Oxford Academic Google Scholar T. MATSUI, T. MATSUI Department of Internal Medicine, Kobe University School of Medicine, Japan Search for other works by this author on: Oxford Academic Google Scholar M. ITO, M. ITO Department of Internal Medicine, Kobe University School of Medicine, Japan Search for other works by this author on: Oxford Academic Google Scholar S. NAKAO, S. NAKAO Department of Internal Medicine, Kobe University School of Medicine, Japan Search for other works by this author on: Oxford Academic Google Scholar T. FUJITA, T. FUJITA Department of Internal Medicine, Kobe University School of Medicine, Japan Search for other works by this author on: Oxford Academic Google Scholar H. KOBAYASHI H. KOBAYASHI Kobayashi Dermatology Clinic, Suma‐ku, Kobe 654, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 1, 1 July 1992, Pages 49–53, https://doi.org/10.1111/j.1365-2133.1992.tb14827.x Published: 01 July 1992
Rectal biopsy in patients presenting to an infectious disease unit with diarrhoeal disease.
Authors: R J Dickinson, H M Gilmour, D B McClelland
Journal: Gut (1979)

<i>BACKGROUND AND PURPOSE:</i> Our purpose was to evaluate the visualization of the artery of Adamkiewicz (AKA) and the anterior spinal artery (ASA) by using multi-detector row CT. Preoperative detection of the AKA and ASA is important for prevention of ischemic complications of thoracoabdominal aortic surgery. <i>METHODS:</i> Data from contrast-enhanced CT of the abdomen of 19 consecutive patients with known or suspected liver disease were evaluated. The scanning range was set from the level of the diaphragm to the lower edge of the liver. After bolus injection of contrast material (100 mL of iohexol, 350 mgI/mL, 5 mL/s), arterial phase scans were obtained by using a four-channel multi-detector row CT scanner. The scanning parameters included a detector row configuration of 4 × 2 mm, a pitch of 5:1, a gantry rotation speed of 0.5 s, 120 kVp, and 150 mAs. Arterial phase coronal multiplanar reconstruction scans obtained parallel to the spinal cord were evaluated by two neuroradiologists. The detectability of ASA and AKA was analyzed. <i>RESULTS:</i> The AKA was visualized on the scans of 13 of 19 patients (68%). The segmental level of AKA origin ranged from T10 to L2. The AKA originated from the left side in nine patients (69%) and the right side in four patients (31%). The ASA was visualized on the scans of all patients (100%). For 16 of the 19 patients, the ASA was detected in its full length from the cranial edge of the scan range. However, the ascending branch of the ASA distal to the junction of the AKA was not detected for the remaining three patients. <i>CONCLUSION:</i> The AKA and ASA can be visualized by using multi-detector row CT with the use of IV administered contrast material. Multi-detector row CT could be a useful tool in the evaluation of spinal vascular structures.
Systemic lupus erythematosus without clinical renal abnormalities: renal biopsy findings and clinical course.
Authors: J R O'Dell, R C Hays, S J Guggenheim, J C Steigerwald
Journal: Annals of the Rheumatic Diseases (1985)

The extent and significance of renal biopsy abnormalities in patients with systemic lupus erythematosus (SLE) without clinical renal abnormalities is controversial. We report 11 consecutive SLE patients who were biopsied without clinical renal abnormalities. All 11 patients had mesangial changes either by light microscopy or by immunofluorescent staining, and none had changes of focal or diffuse proliferative glomerulonephritis. Additionally none had deterioration of renal function during the mean follow-up period of 6.3 years.
Allogeneic bone marrow transplantation in a 7-year-old girl with congenital erythropoietic porphyria: a treatment dilemma
Authors: S.M. Taibjee, O.E. Stevenson, A. Abdullah, C.Y. Tan, P. Darbyshire, C. Moss, H. Goodyear, A. Heagerty, S. Whatley, M.N. Badminton
Journal: British Journal of Dermatology (2007)

Congenital erythropoietic porphyria (CEP, Günther's disease) has a very variable phenotype. In the more severely affected, bone marrow transplantation (BMT) is potentially curative, but is not without risks. We describe a 7‐year‐old girl with CEP characterized by severe photosensitivity but only mild anaemia, in whom the difficult decision to proceed with allogeneic BMT was made after discussion in a multidisciplinary team. She has shown successful engraftment, accompanied by biochemical and clinical resolution of her metabolic disease. She remains well 3 years later, the oldest patient with CEP receiving BMT to survive beyond 12 months. However, she has experienced significant morbidity including florid cutaneous graft‐versus‐host disease with postinflammatory hypopigmentation. Her case is important in highlighting the delay in diagnosis not uncommon in this condition and the complex decision‐making process involved in proceeding with BMT.
Bacterial and Mycotic Infections of Man
Authors: George L. Fite
Journal: JAMA (1965)

First sponsored by the National Foundation for Infantile Paralysis, and designed for the student and practitioner, this standard work has enjoyed much respect and usefulness. The new fourth edition, now published independently, adds 11 new chapters designed to strengthen the theoretical basis of microbiology. The topics include chemical anatomy, genetics, bacterial metabolism, host-resistance, effects of phagocytic cells, humoral factors, and others designed to interest and attract the reader. These, together with the three final chapters on treatment, prevention, and epidemiology, account for the 25% enlargement of the volume. Excellent new articles appear on cholera,<i>Mycoplasma</i>infections, and the micrococci. Some articles, such as those on<i>Pasteurella</i>and<i>Brucella</i>, are thoroughly revised. Others unfortunately are not, having only small additions inserted here and there, and minor editing, where updating was seriously needed. Better presentation in some areas would have made a better book. Fortunately much is first-rate, and the faults are
A piece of my mind. Hold me
Authors: M. H. Bell
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Features of mesenchymal transition in the airway epithelium from chronic rhinosinusitis
Authors: C. Hupin, S. Gohy, C. Bouzin, M. Lecocq, M. Polette, C. Pilette
Journal: Allergy (2014)

Chronic rhinosinusitis (CRS) defines a group of disorders characterized by persistent inflammation of the sinonasal tract. Epithelial changes and structural remodelling are present, but whether epithelial differentiation is altered remains uncertain.To evaluate the differentiation state of the sinonasal epithelium in CRS, sinonasal biopsies from patients with CRS with nasal polyps (CRSwNP) or CRS without nasal polyps (CRSsNP), or with allergic rhinitis (AR), as compared to controls, were processed by immunohistochemistry and RT-qPCR for terminal differentiation (E-cadherin, high molecular weight cytokeratins (Hmw CK) and CK5, vimentin) and lineage differentiation (ß-tubulin IV+ ciliated cells, MUC5AC+ goblet cells, p63 + basal cells). Findings were correlated with subepithelial fibrosis and clinical CT score.Expression of E-cadherin was decreased at protein and mRNA levels in CRSwNP and CRSsNP, as compared to controls. Staining for Hmw CKs was also reduced in CRSwNP and CRSsNP, and CK5 mRNA was decreased in CRSwNP. These features were not due to changes in lineage specification, but associated with increases in vimentin-expressing epithelial cells. In addition, vimentin expression correlated with the basement membrane thickening and with CT score, as well as with tissue eosinophils.Features of epithelial dedifferentiation towards a mesenchymal phenotype are observed in CRSwNP and CRSsNP and correlate with airway fibrosis and inflammation.
A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cells
Authors: Hironori Tsujimoto, Satoshi Ono, Atsushi Matsumoto, Toshinobu Kawabata, Manabu Kinoshita, Takashi Majima, Shuichi Hiraki, Shuhji Seki, Lyle L. Moldawer, Hidetaka Mochizuki
Journal: Journal of Hepatology (2006)
Effect of coronary blood flow on thallium-201 uptake and washout.
Authors: H Nishiyama, R J Adolph, M Gabel, S J Lukes, D Franklin, C C Williams
Journal: Circulation (1982)

Myocardial uptake and washout of thallium-201 (201TI) were studied in an experimental dog model in which regional blood flow to the posterior wall was varied by transient 2-minute occlusion of the circumflex coronary artery to produce transient ischemia and reactive hyperemia. Thallium-201 myocardial activity in a region of interest was determined continuously after i.v. administration by a gamma camera and computer program. Activity in the posterior wall was compared with that in the anterior wall in the same dog and the posterior wall of control dogs. Thallium-201 uptake was directly related to blood flow. With reactive hyperemia, there was a rapid and absolute increase in uptake followed by rapid washout; with ischemia, there was slow and decreased uptake followed by a slow washout. The calculated myocardial activity during washout in both ischemic and hyperemic areas approached values in control dogs long after blood flow had returned to baseline levels. Significant differences in washout slopes were found between the three groups of dogs (-0.156%/min in control dogs, -0.244%/min after reactive hyperemia, and -0.076%/min after transient ischemia, with half-washout times of 5.3 hours, 3.4 hours and 11.0 hours, respectively). These data suggest that both the initial decrease in activity in the ischemic area and the initial excess in the hyperemic area are corrected by different washout rates of ischemic and hyperemic cells during redistribution.
Atlas of Adult Physical Diagnosis
Authors: Kellene Eagen
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Organization in Oregon—Further Discussion.
Authors: George F. Wilson
Journal: JAMA (1906)

Portland, Ore., Feb. 10,1900. <h3>To the Editor:</h3> —Obedient to the call of its president, the City and County Medical Society of Portland, Ore., convened Jan. 3, 1906, to take action on a letter written by Dr. McCormack toThe Journalof the American Medical Association under the caption, "Oregon Practically an Unorganized State," and also on an editorial which appeared in the same issue ofThe Journalbased on the letter in question. The meeting of the society was the largest and most representative in its history, and the discussion which took place was general and of the most animated character. The consensus of thought at the meeting was unanimous and the opinion prevailed that Dr. McCormack by his letter toThe JournalandThe Journalby its editorial did grievous wrong to the profession of Oregon and to its organized societies by publishing the aforesaid letter and editorial and
Parity is not a generalisation problem
Authors: R. I. Damper
Journal: Behavioral and Brain Sciences (1997)

Uninformed learning mechanisms will not discover “type- 2” regularities in their inputs, except fortuitously. Clark &amp; Thornton argue that error back-propagation only learns the classical parity problem – which is “always pure type-2” – because of restrictive assumptions implicit in the learning algorithm and network employed. Empirical analysis showing that back-propagation fails to generalise on the parity problem is cited to support their position. The reason for failure, however, is that generalisation is simply not a relevant issue. Nothing can be gleaned about back-propagation in particular, or learning in general, from this failure.
Weaning from mechanical ventilation with pressure support in patients failing a T-tube trial of spontaneous breathing
Authors: Eric Ezingeard, Eric Diconne, Stéphane Guyomarc’h, Christophe Venet, Dominique Page, Pierre Gery, Régine Vermesch, Monique Bertrand, Juliette Pingat, Bernard Tardy, Jean-Claude Bertrand, Fabrice Zeni
Journal: Intensive Care Medicine (2005)
Abstract B30: Selective small molecule AXL inhibitor BGB324 overcomes acquired drug resistance in non-small cell lung carcinoma models.
Authors: Katarzyna Wnuk-Lipinska, Gro Gausdal, Tone Sandal, Robin Frink, Stefan Hinz, Monica Hellesøy, Lavina Ahmed, Hallvard Haugen, Hallvard Haugen, Liang Xiao, Magnus Blø, David Micklem, John Minna, Rolf Brekken, Longen Zhou, James Lorens
Journal: Clinical Cancer Research (2014)

Abstract Axl is a member of the TAM (Tyro3, Axl and Mer) family of receptor tyrosine kinases that regulate multiple cellular responses including cell survival, proliferation, and migration. Axl expression is associated with a variety of human cancers including non-small cell lung carcinoma (NSCLC), and is predictive of poor patient overall survival. Axl is induced by the epithelial-to-mesenchymal transition (EMT) gene program in cancer cells. Axl signaling is required to maintain EMT-associated features including invasiveness, metastasis, and can confer resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), as well as other chemotherapeutic agents. BGB324 is a potent, reversible and selective small molecule inhibitor of Axl that has recently entered into phase I clinical trials. We evaluated the effects of BGB324 on NSCLC cells in in vitro 3D assays and in mouse xenograft models, in combination with targeted and chemotherapeutic agents. BGB324 in combination with EGFR TKI erlotinib demonstrated a synergistic anti-proliferation effect on NCI-H1299 (mesenchymal, EGFR wild-type, erlotinib-resistant) human NSCLC cells in 3D culture. In mouse xenograft models using NCI-H1299 cells BGB324 treatment significantly enhanced the antitumor acitivity of Docetaxel. Similarly, using the mesenchymal NSCLC cell line A549 (EGFR wild-type), the combination of BGB324 with either erlotinib or anti-VEGF agent bevacizumab showed synergistic or additive anti-tumour activity. Furthermore, in HCC827 (EGFR mutant, erlotinib-sensitive) human NSCLC xenograft model, addition of BGB324 treatment strikely delayed the emergence of acquired resistance to erlotinib. Taken together, these data suggest the first-in-class selective Axl inhibitor BGB324 can overcome acquired resistance in in vivo models of NSCLC. Studies in human NSCLC patient-derived xenograft models and mechanisms of action are in progress. Citation Format: Katarzyna Wnuk-Lipinska, Gro Gausdal, Tone Sandal, Robin Frink, Stefan Hinz, Monica Hellesøy, Lavina Ahmed, Hallvard Haugen, Hallvard Haugen, Liang Xiao, Magnus Blø, David Micklem, John Minna, Rolf Brekken, Longen Zhou, James Lorens. Selective small molecule AXL inhibitor BGB324 overcomes acquired drug resistance in non-small cell lung carcinoma models. [abstract]. In: Proceedings of the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer; 2014 Jan 6-9; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2014;20(2Suppl):Abstract nr B30.
The role of ventriculoatrial interval and preexcitation index in the diagnosis of supraventricular tachycardia mechanism
Authors: T.J. Lobo, P.A. Friedman, R.F. Rea, S.C. Hammill, W.-K. Shen, M.S. Stanton, T.M. Munger, M.J. Osborn, D.L. Packer
Journal: Journal of the American College of Cardiology (1998)
THE DETECTION OF THE MENTALLY DEFECTIVE AMONG IMMIGRANTS
Authors: C. P. KNIGHT
Journal: JAMA (1913)

It will be the purpose of this paper to discuss, not the detection of the insane, but the detection of the idiot, the imbecile and the feeble-minded seeking admission to this country. In this day of large immigration there is scarcely a ship coming into the port of New York which does not carry among its passengers a mental defective of some degree. One of the duties of the medical officer detailed for line inspection in immigration work is to detect such cases and detain them for further mental diagnosis. One can readily see the difficulties presented by the admixture of races coming on each ship and the want of time for conducting such examinations. Aliens of the cabin class are examined on shipboard on the way from quarantine to the docks. The examination is especially difficult, owing to the lack of accommodations, of light, of space, to the excessive
Incompetent Patients with Limited Care in the Absence of Family Consent
Authors: Troyen A. Brennan
Journal: Annals of Internal Medicine (1988)

To understand the factors that distinguish terminally ill, incompetent patients who are given do-not-resuscitate status by physicians against the wishes of the patient's family, I reviewed the charts of 20 such patients (cases) seen in consultation by the ethics committee at the Massachusetts General Hospital over 10 years. I also compared this group of patients with 105 patients who received do-not-resuscitate status with family consent over 3 months in 1986. Socioeconomic factors were similar between cases and controls. Selected prehospitalization characteristics such as history of alcohol or substance abuse, depression, dementia, or other psychiatric diseases were rarely present in the ethics committee group. However, these patients were likely to be incontinent (90%), incapable of any self-care (80%), and have low Glasgow Coma Scale scores (mean, 9.4). The ethics committee cases were relatively young (mean, 63.6 years), were in the hospital for a long period before a do-not-resuscitate decision was reached (mean, 48.2 days), were frequently admitted to intensive care units (75%), and often received ventilatory (70%) and pressor medication (50%) support. Eighty percent of the ethics committee cases died in the hospital. The control do-not-resuscitate patients were much less sick and received much less invasive support. This research suggests that the ethics committee at the study hospital was not redefining the principles of medical ethics that underlie decisions not to resuscitate when it recommended limited care in the absence of family consent, but rather was recommending such limitations only for patients in whom it appeared further care was futile.
Interleukin-1 expression by neutrophils in rheumatoid arthritis.
Authors: J A Quayle, S Adams, R C Bucknall, S W Edwards
Journal: Annals of the Rheumatic Diseases (1995)

OBJECTIVE--To determine if neutrophils from blood and synovial fluid of patients with rheumatoid arthritis and other joint arthropathies express interleukin-1 beta mRNA. METHODS--RNA was isolated from neutrophils from patient and control blood, and synovial fluid of patients, probed in northern blots, and quantified by densitometry. It was also isolated and analysed from control blood neutrophils after incubation in vitro with granulocyte macrophage colony stimulating factor (GM-CSF). RESULTS--Neutrophils from the synovial fluid of patients with rheumatoid arthritis contained low levels of mRNA for interleukin-1 beta--between 0.1 and 2% of those observed during stimulation of control neutrophils with GM-CSF for one hour. Higher levels (4-40% of the maximal GM-CSF values) were observed in blood neutrophils from patients with rheumatoid arthritis. CONCLUSIONS--Neutrophils contribute to the cytokine network in rheumatoid arthritis. In some circumstances, activation of transcription may occur within the circulation of these patients.
Safety and transcervical endometrial resection
Authors: J.J. Beutler, H.A. Koomans, F. Parramón, J.M. Fernández, C. Hernández, R. Garcia, W. Ricart, A. Villalonga, WillemM. Ankum, Jan Vonk, G.L.S. Rankin
Journal: The Lancet (1995)