tbuckley/cabot-search huggingface dataset:
PTU-127 The impact of surgery on health related quality of life in ulcerative colitis: Abstract PTU-127 Figure 1
Authors: P Swinburn, H Elwick, K Bean, A Curry, S Patel, K Bodger, A Lloyd
Journal: Gut (2012)

<h3>Introduction</h3> Surgery is perceived as curative for ulcerative colitis but may not restore full health. Health-related QoL in ulcerative colitis is often measured using disease-specific instruments (eg, the Inflammatory Bowel Disease Questionnaire, IBD-Q) and less commonly using generic instruments (eg, EuroQol EQ5D). The generic approach measures QoL on a common "utility" scale ranging from 0 (dead) to 1 (full health). This allows for more useful comparison of impaired QoL relative to a healthy population or to individuals with other diseases. To examine the impact on surgery on patients9 QoL, this study captured data on both disease-specific and generic QoL on patients post-colectomy where published data are limited, as well as patients without colectomy. Utility scores of patients across the full spectrum of disease severity in UC were also evaluated. <h3>Methods</h3> 230 UC patients (including 30 post-surgery patients) were recruited along with 100 age and gender matched controls. Participants completed an online survey which comprised the Simple Clinical Colitis Activity Index, EuroQol EQ-5D and the IBD-Q. Basic sociodemographic and clinical data were also collected. Disease severity was categorised using established cut-off values for the IBD-Q. EQ-5D utility scores were compared across disease severity, among post-surgery patients vs non-surgery patients, and among post-surgery patient vs controls. <h3>Results</h3> EQ-5D utility scores demonstrate a clear relationship with disease severity as categorised by the IBDQ (<i>ANOVA</i> F(2,329)=5.544, p=0.004) with post-surgery patients reporting poorer QoL than non-surgery patients (p=0.016) or controls (p=0.03). Those with the most severe disease report values comparable to colorectal cancer (Tappenden, 2007). <h3>Conclusion</h3> Global QoL (utilities) among post-surgical patients was significantly poorer than both age and gender matched population controls and patients in remission or with mildly active colitis, suggesting that identification of effective new drug therapies for severe disease remains the goal for optimising long term QoL. <h3>Competing interests</h3> P Swinburn Grant/Research Support from: Abbott Laboratories Ltd, H Elwick Grant/Research Support from: Abbott Laboratories Ltd, K Bean: None Declared, A Curry: None declared, S Patel: None declared, K Bodger Consultant for: Abbott Laboratories Ltd, A Lloyd Grant/Research Support from: Abbott Laboratories Ltd. <h3>Reference</h3> 1. <b>Tappenden P</b>, Chilcott J, Eggington S, <i>et al.</i> Option appraisal of population-based colorectal cancer screening programmes in England. <i>Gut</i> 2007;<b>56</b>:677–84.
Hormonal Control of Pancreatic Growth
Authors: David L. Mainz, Owen Black, Paul D. Webster
Journal: Journal of Clinical Investigation (1973)

Investigations have outlined pancreatic secretory and synthetic responses to gastrointestinal hormones. However, there is little information concerning hormonal influences on pancreatic growth. These studies were designed to examine effects of chronic administration of bethanechol and cholecystokinin-pancreozymin (CCK-PZ) on the pancreas. Male albino rats were given saline, bethanechol, 6 mg/kg, or CCK-PZ, 20 U/kg, intraperitoneally twice daily and killed after 5 days. The following changes were studied; pancreatic weight; RNA, DNA, and protein content; and [(14)C]thymidine incorporation into DNA. Bethanechol administration was associated with a 20% increase in pancreatic weight and a 33% increase in mg protein/100 mug DNA. In bethanechol-treated groups, amounts of DNA/gram body weight and incorporation of [(14)C]thymidine into DNA were similar to controls. CCK-PZ administration was associated with a 71% increase in pancreatic weight and a 38% increase in mg protein/100 mug DNA. In CCK-PZ-treated groups, amounts of DNA/gram body weight were increased by 42% and [(14)C]thymidine incorporation into DNA was increased by 185%. These studies indicate that bethanechol administration was associated with increases in pancreatic cell mass (hypertrophy). CCK-PZ administration was associated with increases in cell mass and cell numbers (hypertrophy and hyperplasia). This information suggests the importance of CCK-PZ in maintaining pancreatic functional integrity. Although bethanechol and CCK-PZ elicit similar secretory responses, their mode of action on the cell, at least as far as growth influences are concerned, appears to be different.
Association and cosegregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats.
Authors: M Volpe, G Iaccarino, C Vecchione, D Rizzoni, R Russo, S Rubattu, G Condorelli, U Ganten, D Ganten, B Trimarco, K Lindpaintner
Journal: Journal of Clinical Investigation (1996)

While hypertension is a major risk factor for stroke, it is not its sole determinant. Despite similar blood pressures, spontaneously hypertensive rats (SHR) do not share the predisposition to cerebrovascular disease typical of stroke-prone spontaneously hypertensive rats (SHRSP). We investigated vascular function in male SHR and SHRSP as well as in SHRSP/SHR-F2 hybrid animals. Animals were maintained on the appropriate dietary regimen necessary for the manifestation of stroke. Among the hybrid animals, a group of stroke-prone and a group of stroke-resistant rats were selected. Blood pressure was similar in all groups. Endothelium-independent vascular reactivity tested on isolated rings of thoracic aorta and basilar artery after death showed similar contractile and dilatory responses to serotonin and nitroglycerin, respectively, in all groups. In contrast, endothelium-dependent relaxation, in response to acetylcholine or substance P, was markedly reduced in SHRSP compared with SHR. Similarly, reduced vasodilatory responses were present in aortae of F2 rats that had suffered a stroke when compared with SHR or F2 rats resistant to stroke. The observed association and cosegregation of stroke with significant and specific impairment of endothelium-dependent vasorelaxation among SHRSP and stroke-prone F2 hybrids, respectively, suggest a potential causal role of altered endothelium-dependent vascular relaxation in the pathogenesis of stroke.
Early Recognition of Potentially Fatal Necrotizing Fasciitis
Authors: Ivan Stamenkovic, P. Daniel Lew
Journal: New England Journal of Medicine (1984)

Necrotizing fasciitis is a rare, rapidly progressing soft-tissue infection. Early clinical recognition is difficult, and there is often a fatal delay in appropriate treatment. We evaluated the use of frozen-section biopsies for the rapid diagnosis of this disease in its early stages. Nineteen cases of necrotizing fasciitis were studied over a 13-year period. In all eight cases in which frozen-section biopsy was performed within zero to four days (average, 21 hours) after the onset of symptoms, histologic study confirmed the diagnosis, and surgical débridement was immediately performed. Only one patient died. In 11 patients, the diagnosis was made on clinical grounds, and surgical therapy was delayed for 1 to 15 days (average, 6) after the onset of symptoms because of failure to recognize the disorder immediately. Eight patients died (P<0.02). Our study indicates that rapid performance of frozen-section soft-tissue biopsy early in the evolution of a suspect lesion may provide a definitive and life-saving diagnosis. (N Engl J Med 1984; 310:1689–93.)
"Missed pill" conception: fact or fiction?
Authors: M A Shaw, D J Back, M C L. Orme, S F M Grimmer
Journal: BMJ (1985)

We also doubt whether, after missing a pill at the start of a packet, the normal practice of taking wo pills would increase the risk of ovulation.This is because a good dose of progestogen as well as oestrogen is thereby given, and Yuzpe et al have shown that a similar regimen is a good postcoital contraceptive even during spontaneous cycles.)
Modification of the Substrate for Maintenance of Idiopathic Human Atrial Fibrillation
Authors: Sabine Ernst, Michael Schlüter, Feifan Ouyang, Afsaneh Khanedani, Riccardo Cappato, Joachim Hebe, Marius Volkmer, Matthias Antz, Karl-Heinz Kuck
Journal: Circulation (1999)

Background —Catheter ablative techniques to modify the substrate to maintain atrial fibrillation (AF) require the creation of continuous radiofrequency current-induced ablation lines. This study was designed to assess the efficacy and safety of nonfluoroscopic mapping in this setting. Methods and Results —A total of 45 consecutive patients with idiopathic AF were studied. The first 13 underwent ablation confined to the left atrium by creating a circular line isolating the pulmonary vein ostia and a second line connecting the former with the mitral annulus. Subsequently, 12 of these patients underwent a procedure confined to the right atrium (RA), where attempts were made to create an isthmus line between the inferior vena cava and the tricuspid annulus, an anterior line connecting the tricuspid annulus with the superior vena cava, and an intercaval line between the ostia of the inferior and superior venae cavae. In the last 32 patients, only the RA approach was performed. Technical difficulties prevented the creation of the intended left atrial line pattern: all patients experienced recurrences. A 100% recurrence rate was also observed after subsequent RA ablation, despite creation of a complete line pattern in 4 of 12 patients. Of the final 32 patients, AF recurred in 94%; a complete ablation line pattern had been achieved in 18 patients (56%), 16 of whom had recurrences. Conclusions —The electroanatomically-guided creation of extended radiofrequency current lesions is technically feasible only in the RA. However, procedural success in the RA does not suppress recurrences of AF in the majority of patients.
Reply to the Letter to the Editor “Critical appraisal of the Minimal Clinical Recommendations (MCR) of the European Society for Medical Oncology (ESMO): challenges for a European framework for the development of clinical practice guidelines”,by B. Fervers, T. Philip andG. P. Browman (Ann Oncol 2002; 13: 1507–1509)
Authors: R. Stahel
Journal: Annals of Oncology (2002)
GW25-e4320 A prospective randomized controlled study on Median sternotomy closure with titanium plate fixation in high risk patients
Authors: Huang Zhifeng, Zheng Shaoyi, Lai Wen, Mai Mingjie, Chen Xinquan, Liu Zuan, Chen Huade, Chen Han-Xi, Ma Lianghua, Li Hanhua
Journal: Journal of the American College of Cardiology (2014)
Obama vows to pursue health reform plans despite new focus on banks
Authors: J. H. Tanne
Journal: BMJ (2010)

In his state of the union speech last week, President Barack Obama waited until he was well into his hour long speech before discussing health reform as he emphasised instead plans aimed at improving the US economy and increasing jobs. When the president did get round to the subject of heath cover he called for “everyone to take another look at the plan we’ve proposed [on health reform]” to ensure more people have access to healthcare insurance.

The president spoke before a joint session of Congress. A state of the union speech discussing the current state of the nation is required by the Constitution and is traditionally given every year in January.

His chief of staff, Rahm Emanuel, told the New York Times …
Metronomic cyclophosphamide: An alternative treatment for hepatic epithelioid hemangioendothelioma
Authors: Zaher Lakkis, Stefano Kim, Eric Delabrousse, Marine Jary, Thierry Nguyen, Georges Mantion, Bruno Heyd, Catherine Lassabe, Christophe Borg
Journal: Journal of Hepatology (2013)

Hepatic epithelioid hemangioendothelioma is a rare liver mesenchymatous tumor with an epithelial aspect developed from endothelial cells with a lack of validated therapeutic options at metastatic stage. Metronomic chemotherapy has been described as an anti-angiogenic therapy leading to the depletion of circulating endothelial progenitors. We report the results of two patients treated for metastatic hemangioendothelioma with metronomic cyclophosphamide chemotherapy. Following initiation of metronomic cyclophosphamide chemotherapy (50mg once a day continuously), the two patients exhibited significant clinical improvement and decrease in metastasis size without any clinically relevant side-effect. Metronomic cyclophosphamide could be proposed as a new therapeutic option to treat metastatic hepatic epithelioid hemangioendothelioma.
Human basophils interact with memory T cells to augment Th17 responses
Authors: Keiko Wakahara, Nobuyasu Baba, Vu Quang Van, Philippe Bégin, Manuel Rubio, Pasquale Ferraro, Benoît Panzini, Ramses Wassef, Raymond Lahaie, Yves Caussignac, Raja Tamaz, Carole Richard, Geneviève Soucy, Guy Delespesse, Marika Sarfati
Journal: Blood (2012)
Safer treatment doses for low molecular weight heparins: summary of a safety report from the National Patient Safety Agency
Authors: T. Lamont, D. Cousins, C. Rosario
Journal: BMJ (2010)

Low molecular weight heparins such as enoxaparin are used to prevent and treat venous thromboembolism and to treat acute coronary syndromes. These medicines are given parenterally by intravenous or subcutaneous injection. They offer advantages over regular unfractionated heparin: they are seen as effective,1 with a low risk of heparin induced thrombocytopenia; patients are likely to spend less time in hospital because of the long duration of action and, where appropriate, subcutaneous administration. In the UK, low molecular weight heparins are considered the treatment of choice and are increasingly being used including outside hospital. Indicative figures for prescribing in England in 2008/092 suggest that over a third (1.1 million) of all enoxaparin doses of 60 ml or greater were prescribed in the community.

However, different clinical indications require different doses and frequency. For instance doses for treatment depend on the patient’s weight, unlike the standard doses given for prophylactic use. Underdosing can increase the risk of a further thromboembolic event, while overdosing can increase the risk of bleeding. Accurate dosing and careful monitoring is needed, particularly for those with renal impairment, because low molecular weight heparins are excreted through the kidneys.

Concerns about inconsistent use of prophlyaxis for venous thromboembolism has led to high-profile guidelines by the UK’s National Institute for Health and Clinical Excellence.3 But clinicians may be less aware of the potential for harm from errors in treatment doses. A recent audit of 16 hospitals in Wales showed that weight was not recorded in almost half of patients receiving low …
Stroke Care Within the Golden Hour
Authors: Kyle Fischer, Vince McDonough
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Abstract 2246: Steam distilled ginger extract inhibits endometrial cancer cell proliferation by activating P53 and causing apoptosis.
Authors: Yang Liu, Rebecca J. Whelan, Bikash R. Pattnaik, Kai David Ludwig, Rosalina V. Landeros, Enkateswar Subudhi, Helen Rowland, Nicholas Claussen, Noah Zucker, Shitanshu Uppal, David M. Kushner, Mildred Felder, Manish S. Patankar, Arvinder K. Kapur
Journal: Cancer Research (2013)

Abstract Phenolic compounds present in dry ginger powder or solvent extracts of ginger roots induce cell cycle arrest and apoptosis in skin, breast, prostate, colon, and ovarian cancer cells. Another class of bioactive compounds, the terpenes, can be isolated by steam distillation of the ginger rhizomes. In this study, we examine the anti-cancer properties of Steam Distilled Ginger Extracts (SDGE) on endometrial cancer cells. SDGE at an IC-50 of 1.5 micrograms/ml inhibited the proliferation of two endometrial cancer cell lines, ECC-1 and Ishikawa. Decreased proliferation of Ishikawa and ECC-1 cells was a direct result of SDGE-induced-apoptosis as demonstrated by Annexin V FITC staining and increased expression of cleaved caspase 3. GC-MS analysis allowed us to identify 22 distinct terpenes in SDGE. Gingerols and other non-terpene phenolic compounds were not present in SDGE. Neral and Geranial constituted 25-35% of the total SDGE terpenes and were found to inhibit endometrial cancer cell proliferation. On the other hand, camphene and α-pinene, which together constitute 10% of SDGE, showed no effect on the proliferation of ECC-1 and Ishikawa cells. SDGE at concentrations as low as 25 nanograms/ml caused a rapid increase in intracellular calcium levels and an approximate decrease of 20% in the mitochondrial membrane potential. Ser-15 of p53 was phosphorylated after a 15 minute treatment of the cancer cells with SDGE (250 nanograms/ml). This activation of p53 was associated with a 90% decrease in Bcl2, whereas no effect was observed on Bax. Pifithrin-α, an inhibitor of p53, attenuated the anti-cancer effects of SDGE that result from apoptosis. In addition, SDGE (1.5 microgram/ml) was unable to induce apoptosis in the p53-negative ovarian cancer cell line, SKOV3. Our data therefore indicates that specific terpenes present in SDGE are highly efficient in controlling the growth of p53-expressing cancer cells. We therefore propose that SDGE and its constituent bioactive terpenes should be further investigated as anti-cancer agents. Citation Format: Yang Liu, Rebecca J. Whelan, Bikash R. Pattnaik, Kai David Ludwig, Rosalina V. Landeros, Enkateswar Subudhi, Helen Rowland, Nicholas Claussen, Noah Zucker, Shitanshu Uppal, David M. Kushner, Mildred Felder, Manish S. Patankar, Arvinder K. Kapur. Steam distilled ginger extract inhibits endometrial cancer cell proliferation by activating P53 and causing apoptosis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2246. doi:10.1158/1538-7445.AM2013-2246
The Offensive Wrist
Authors: MARK L. JACKSON, C RICHARD GOLDFARB, F ONGSENG
Journal: Clinical Nuclear Medicine (1986)

Fencing between injection of Tc-99m MDP and imaging resulted in a diffuse increase in radioactivity in the asymptomatic wrist of a right-handed fencer. Repeat study two weeks later showed normal distribution of radiopharmaceutical. At that time, the athlete was fenced into the patient waiting area between injection and scan.
Coffee Drinking and Myocardial Infarction
Authors: A.L. Klatsky
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Much of the letter by Jick et al concerns our attempt to explain the variation among studies. As our Table 4 clearly indicated, the listing of proportions of "heavy" coffee-drinkers in various studies was made without precise equilibration of the number of cups of coffee drunk per day. Many persons who answered "yes" to the question "Have you usually, in the past year, drunk more than six cups of coffee per day?" may have imprecisely interpreted the query as "<i>six or more</i>cups per day?" Therefore, we thought that the comparison was appropriate. However, we now agree that a strict interpretation categorizes our positive responders as drinking seven or more cups of coffee per day. Such categorization is closer to Paul's<sup>1</sup>200 or more cups per month group that included only 7% of controls. The new Framingham Heart Study data, presented by Jick et al, suggest
Beware renal adverse effects of anti-vascular endothelial growth factor treatment
Authors: L. Keir, F. v. Moorsel, M. A. Saleem, A. Richards
Journal: BMJ (2012)

Treatment based on antibodies to vascular endothelial growth factor (VEGF) has dramatically improved the management of wet age related macular degeneration.1 The debate surrounding the off label use of bevacizumab versus ranibizumab raised many issues. However, we were worried by the lack of a caution regarding the potential renal side effects associated with this class of drugs.

VEGF is important in maintaining renal glomerular integrity and …
Physician Ownership of Physical Therapy Services
Authors: Jean M. Mitchell
Journal: JAMA (1992)

To evaluate the effects of physician ownership of freestanding physical therapy and rehabilitation facilities on utilization, charges, profits, and three measures of service characteristics for physical therapy treatments.Statistical comparison by physician joint venture ownership status of freestanding physical therapy and comprehensive rehabilitation facilities providing physical therapy treatments in Florida.A total of 118 outpatient physical therapy facilities and 63 outpatient comprehensive rehabilitation facilities providing services in Florida during 1989. The data from the facilities were collected under a legislative mandate.Visits per patient, average revenue per patient, percent operating income, percent markup, profits per patient, licensed therapist time per visit, and licensed and nonlicensed medical worker time per visit.Visits per patient were 39% to 45% higher in joint venture facilities. Both gross and net revenue per patient were 30% to 40% higher in facilities owned by referring physicians. Percent operating income and percent markup were significantly higher in joint venture physical therapy and rehabilitation facilities. Licensed physical therapists and licensed therapist assistants employed in non-joint venture facilities spend about 60% more time per visit treating physical therapy patients than licensed therapists and licensed therapist assistants working in joint venture facilities. Joint ventures also generate more of their revenues from patients with well-paying insurance.Our results indicate that utilization, charges per patient, and profits are higher when physical therapy and rehabilitation facilities are owned by referring physicians. With respect to service characteristics, joint venture firms employ proportionately fewer licensed therapists and licensed therapist assistants to perform physical therapy, so that licensed professionals employed in joint venture businesses spend significantly less time per visit treating patients. These results should be of interest to the medical profession, third-party payers, and policymakers, all of whom are concerned about the consequences of physician self-referral arrangements.