tbuckley/cabot-search huggingface dataset:
THU0575 Long-Term QOL Evaluation with AIMS-2 in Patients with Rheumatoid Arthritis - Two-Year Evaluation in Patients Receiving Treatment with Biologicals
Authors: M. Kaneko, S. Honjo
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> According to the T2T recommendation, the primary target in the treatment of rheumatoid arthritis (RA) is to achieve the state of clinical remission, and the desired treatment target should be maintained throughout the remaining course of the disease.1) To date, reports have been published on cases where clinical remission was maintained with the use of biologicals, etc.,2) but there have been few reports published on cases where QOL of the patients was maintained as well. <h3>Objectives</h3> The present study was designed to evaluate whether or not QOL was maintained in patients with RA remaining in the state of clinical remission or low disease activity, using AIMS-2 (Arthritis Impact Measurement Scales version 2) as a tool for QOL evaluation. <h3>Methods</h3> The investigation using AIMS-2 was carried out between May and August in 2011 and 2012, involving patients with RA remaining in the state of clinical remission or low disease activity while receiving treatment with biologicals at our clinic. <h3>Results</h3> Cooperation with the investigation for the 2-year period was obtained from 153 RA patients. The biological preparations used were etanercept (62 cases), infliximab (39 cases), tocilizumab (21 cases), abatacept (16 cases), adalimumab (14 cases) and golimumab (1 case). The mean score of each AIMS-2 item in 2012 differed little from that in 2011, allowing us to confirm that QOL was also maintained in these patients. The score for pain, which is one of the factors known to markedly reduce QOL, improved from 9.8 to 9.0, and this was the only parameter showing a significant difference between the years 2011 and 2012 (P=0.002).(Table) <h3>Image/graph:</h3> <h3>Conclusions</h3> The results of this investigation allowed us to confirm that QOL was also maintained in patients with RA in whom treatment with biologicals maintained the state of clinical remission or low disease activity for a long period of time. According to the EULAR recommendations for the role of the nurse in the management of chronic inflammatory arthritis, nurses should participate in comprehensive disease management to control disease activity, to reduce symptoms and to improve patient-preferred outcomes.3) We believe that one of the approaches possibly contributing to long-term maintenance of QOL is that nurses proactively participate in QOL assessment with AIMS-2, etc. and to have close contact with individual RA patients; to facilitate early detection of abnormalities and changes in responses to treatment and to take early countermeasures on the basis of these findings. <h3>References</h3> Josef S Smolen, et al. Ann Rheum Dis 2010;69:631-637 Josef S Smolen, et al. Ann Rheum Dis 2012;71(Suppl3):367 Yvonne van Eijl-Hustings, et al. Ann Rheum Dis 2012;71:13-19 <h3>Disclosure of Interest</h3> None Declared
349 RELATION BETWEEN NON-INVASIVE LIVER FIBROSIS TESTS AND CIRRHOSIS COMPLICATIONS
Authors: G. Roquin, S. Bertrais, J. Boursier, A. Pascaud, H. Common, C. Givel, S. Casant, A. Blanchi, M. Domecq, J. Brethomeau, N. L'Hirondel, A. de Geyer, C. Vinciguerra, I. Fouchard-Hubert, F. Oberti, P. Calès
Journal: Journal of Hepatology (2011)
Effects of cellulose derivatives and poly(ethylene oxide)–poly(propylene oxide) tri-block copolymers (Pluronic®surfactants) on the properties of alginate based microspheres and their interactions with phagocytic cells
Authors: Argaw Kidane, Paul Guimond, Tzu Chi Rob Ju, Margaret Sanchez, Janet Gibson, Adam North, Harm HogenEsch, Terry L. Bowersock
Journal: Journal of Controlled Release (2002)
Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat.
Authors: H Koto, J C Mak, E B Haddad, W B Xu, M Salmon, P J Barnes, K F Chung
Journal: Journal of Clinical Investigation (1996)

We studied the in vivo mechanism of beta-adrenergic receptor (beta-AR) hyporesponsiveness induced by intratracheal instillation of interleukin-1beta (IL-1beta, 500 U) in Brown-Norway rats. Tracheal and bronchial smooth muscle responses were measured under isometric conditions ex vivo. Contractile responses to electrical field stimulation and to carbachol were not altered, but maximal relaxation induced by isoproterenol (10(-6)-10(-5) M) was significantly reduced 24 h after IL-1beta treatment in tracheal tissues and to a lesser extent, in the main bronchi. Radioligand binding using [125I]iodocyanopindolol revealed a 32+/-7% reduction in beta-ARs in lung tissues from IL-1beta-treated rats, without any significant changes in beta2-AR mRNA level measured by Northern blot analysis. Autoradiographic studies also showed significant reduction in beta2-AR in the airways. Isoproterenol-stimulated cyclic AMP accumulation was reduced by IL-1beta at 24 h in trachea and lung tissues. Pertussis toxin reversed this hyporesponsiveness to isoproterenol but not to forskolin in lung tissues. Western blot analysis revealed an IL-1beta-induced increase in Gi(alpha) protein expression. Thus, IL-1beta induces an attenuation of beta-AR-induced airway relaxation through mechanisms involving a reduction in beta-ARs, an increase in Gi(alpha) subunit, and a defect in adenylyl cyclase activity.
Polymorphonuclear Neutrophils Move into the Fast Lane in Chronic Obstructive Pulmonary Disease
Authors: Takahiro Nakajima, Caroline A. Owen
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Polymorphonuclear Neutrophils Move into the Fast Lane in Chronic Obstructive Pulmonary DiseaseChronic obstructive pulmonary disease (COPD) is characterized by an abnormal inflammatory response of the lung to inhaled noxious particles and gases.The main risk factor for
A critical assessment of an open circuit technique for measuring oxygen consumption
Authors: C. T. KAPPAGODA, R. J. LINDEN
Journal: Cardiovascular Research (1972)

Journal Article A critical assessment of an open circuit technique for measuring oxygen consumption Get access C. T. KAPPAGODA, C. T. KAPPAGODA From the Cardiovascular Unit, Department of Physiology, University of Leeds, Leeds 2 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. J. LINDEN R. J. LINDEN From the Cardiovascular Unit, Department of Physiology, University of Leeds, Leeds 2 Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 6, Issue 5, September 1972, Pages 589–598, https://doi.org/10.1093/cvr/6.5.589 Published: 01 September 1972
Perloff’s Clinical Recognition of Congenital Heart Disease
Authors: Thomas M. Bashore
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply to N. Lathia et al
Authors: Nicole M. Kuderer, David C. Dale, Jeffrey Crawford, Gary H. Lyman
Journal: Journal of Clinical Oncology (2010)

Lathia et al comment on our meta-analysis of granulocyte colony-stimulating factor (G-CSF) primary prophylaxis reported in Journal of Clinical Oncology in 2007, demonstrating significant reductions in infection-related mortality, all-cause early mortality, and febrile neutropenia in patients randomly assigned to receive primary G-CSF prophylaxis compared with those receiving secondary G-CSF prophylaxis or untreated controls. Among the 17 eligible randomized controlled trials, relative risk for febrile neutropenia was 0.54 (95% CI, 0.43 to 0.67) overall and 0.61 (95% CI, 0.53 to 0.72) for filgrastim. Despite the use of different statistical programs and exclusion of certain trials, Lathia et al arrived at estimates of treatment effect nearly identical to ours. To consider all relevant studies, we included the study by Zinzani et al, because it reported clinically relevant infections during the period of neutropenia, a better approximation for febrile neutropenia than the alternative of including all neutropenic events. As Lathia et al confirm, removal of the Zinzani et al study from the meta-analysis would not only reduce heterogeneity but also have no clinically meaningful impact on estimated treatment effect, nor would it alter any study conclusions. No significant heterogeneity was observed in filgrastim studies, regardless of the inclusion of the study by Zinzani et al. In addition, because Zinzani et al reported no meaningful beneficial effect of G-CSF on early mortality or infection-related mortality, inclusion of this study in the meta-analysis is the more conservative approach. For each trial using a 2 2 factorial design, rather than assessing the visual effect of point estimates as Lathia et al suggest, we formally assessed interaction between randomization strata. Statistically significant interaction between subgroups was determined by comparing the ratio of the difference in the natural logarithm of relative risks and the SE of the difference in log relative risks with the standard normal distribution. Significant interaction was observed for survival between chemotherapy and G-CSF assignments in the Osby et al study but not in the Fossa et al study. Therefore, separate comparisons of the results for the Osby et al study were included. Although we recognize that investigators may differ in their approaches to the analysis in this circumstance, no meaningful differences in effect estimates were observed with either approach. The minimal differences in estimated rates for the two studies noted by Lathia et al are most likely attributable to rounding differences, use of differing statistical programs, and varying presence of updated study information. Overall, it is gratifying that Lathia et al have essentially replicated and confirmed the results of our meta-analysis.
Reovirus-induced liver disease in severe combined immunodeficient (SCID) mice. A model for the study of viral infection, pathogenesis, and clearance.
Authors: A George, S I Kost, C L Witzleben, J J Cebra, D H Rubin
Journal: The Journal of Experimental Medicine (1990)

Adult severe combined immunodeficient (SCID) mice can be infected by the oral route with reovirus, and a systemic infection can be established. Infectious virus is recovered from all internal organs, and the mice die in 4-6 wk. Chronic, discrete inflammatory lesions appear in the liver of infected mice, and are associated with hepatocytes containing demonstrable levels of viral antigen. The adoptive transfer of Peyer's patch (PP) cells from congenic mice before infection protects the SCID mice against disease and death. Immune donor PP cells can be distinguished from nonimmune cells by their ability to contain and resolve infection by 1 wk after challenge.
Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man.
Authors: J S Flier, M Mueckler, A L McCall, H F Lodish
Journal: Journal of Clinical Investigation (1987)

We used the complementary DNA for the human hepatoma Hep G2 glucose transporter to determine the distribution of glucose transporter messenger RNA (mRNA) in rat and human tissues. Under stringent hybridization conditions, a single 2.8-kilobase (kb) transcript is seen in all rat and human tissues examined. The mRNA is most abundant in brain, and is especially enriched in the brain microvascular fraction. The mRNA abundance in rat muscle and fat is 5% that in brain. Rat liver (both adult and fetal) and human liver have very little 2.8-kb mRNA, but it is abundant in cultured human fibroblasts and EB virus-transformed lymphoblasts. The same size mRNA is present in leg muscle of two type II diabetic patients. A very homologous glucose transporter mRNA is expressed in both insulin-sensitive and -insensitive tissues of rat and man. Hepatocytes, which have abundant glucose transport, may express a homologous but nonidentical glucose transporter.
The Bowman Lecture on the Relation of Certain Diseases of the Eye to Gout
Authors: J. Hutchinson
Journal: BMJ (1884)

<b>Background:</b> Little is known about the effect of surgical training on outcomes in thoracic surgery. The impact of surgeon training on outcomes following lung resection was examined, focusing on lobectomy as a marker operation. <b>Methods:</b> 328 consecutive patients who underwent lobectomy at our institution between 1 October 2001 and 30 June 2003 were studied. Data were collected prospectively during the patient’s admission as part of routine clinical practice and validated by a designated audit officer. Patient characteristics and postoperative outcomes were compared between trainee led and consultant led operations. <b>Results:</b> In 115 cases (35.1%) the operation was performed by a trainee thoracic surgeon as the first operator. There were no significant differences in patient characteristics between the two groups. In-hospital mortality was similar for operations led by trainees and consultants (3.5% and 2.8%, respectively; p&gt;0.99). Outcomes in the two groups did not differ significantly with respect to respiratory, cardiovascular, renal, neurological, chest infection, bleeding, and gastrointestinal complications. Survival rates at 1 year were 82.6% for procedures led by trainees compared with 81.7% for procedures led by consultants (p = 0.83). <b>Conclusions:</b> With appropriate supervision, trainee thoracic surgeons can perform lobectomies safely without compromising short or intermediate term patient outcome.
Time series prediction of plasma hormone concentration. Evidence for differences in predictability of parathyroid hormone secretion between osteoporotic patients and normal controls.
Authors: K Prank, S J Nowlan, H M Harms, M Kloppstech, G Brabant, R D Hesch, T J Sejnowski
Journal: Journal of Clinical Investigation (1995)

Recent evidence links osteoporosis, a disease of bone remodeling, to changes in the dynamics of parathyroid hormone secretion. We use nonlinear and linear time series prediction to characterize the secretory dynamics of parathyroid hormone in both healthy human subjects and patients with osteoporosis. Osteoporotic patients appear to lack the periods of high predictability found in normal humans. Our results may provide an explanation for why an intermittent administration of parathyroid hormone is effective in restoring bone mass in osteoporotic patients.
Cellular distribution of bronchus-associated lymphoid tissue in rheumatoid arthritis.
Authors: A Sato, H Hayakawa, H Uchiyama, K Chida
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Bronchus-associated Lymphoid tissue (BALT) has been reported to be present in the lungs of patients with rheumatoid arthritis (RA). However, little is known about the structure and cellular distribution of BALT in this disease, so we investigated these points using immunohistochemical methods. The subjects were eight RA patients with BALT in biopsy specimens and a histologic diagnosis of follicular bronchiolitis. Seven patients had cough and purulent sputum, and four patients had positive sputum cultures. BALT was histologically composed of four distinct regions, which were the lymphoepithelium, the dome area, the follicular area, and the parafollicular area. Surface IgM+ B cells were predominant in the follicular area, whereas IgA+ cells were scattered in the dome and parafollicular areas. T cells were mainly found in the parafollicular area (CD4+ > CD8+), and most of them expressed the T Cell receptor alpha beta (alpha beta TCR). These findings were similar to those described previously for BALT in diffuse panbronchiolitis, which manifests as a chronic respiratory infection. The present study indicated that extrinsic stimulation as well as alterations of the immune response are involved in the development of BALT in RA, although the exact mechanism requires further clarification.
Toward Evidence-Based Medical Statistics. 2: The Bayes Factor
Authors: Steven N. Goodman
Journal: Annals of Internal Medicine (1999)

Bayesian inference is usually presented as a method for determining how scientific belief should be modified by data. Although Bayesian methodology has been one of the most active areas of statistical development in the past 20 years, medical researchers have been reluctant to embrace what they perceive as a subjective approach to data analysis. It is little understood that Bayesian methods have a data-based core, which can be used as a calculus of evidence. This core is the Bayes factor, which in its simplest form is also called a likelihood ratio. The minimum Bayes factor is objective and can be used in lieu of the P value as a measure of the evidential strength. Unlike P values, Bayes factors have a sound theoretical foundation and an interpretation that allows their use in both inference and decision making. Bayes factors show that P values greatly overstate the evidence against the null hypothesis. Most important, Bayes factors require the addition of background knowledge to be transformed into inferences--probabilities that a given conclusion is right or wrong. They make the distinction clear between experimental evidence and inferential conclusions while providing a framework in which to combine prior with current evidence.
Improved reliability of lymphoma diagnostics via PCR-based clonality testing: — Report of the BIOMED-2 Concerted Action BHM4-CT98-3936
Authors: J H J M van Krieken, A W Langerak, E A Macintyre, M Kneba, E Hodges, R Garcia Sanz, G J Morgan, A Parreira, T J Molina, J Cabeçadas, P Gaulard, B Jasani, J F Garcia, M Ott, M L Hannsmann, F Berger, M Hummel, F Davi, M Brüggemann, F L Lavender, E Schuuring, P A S Evans, H White, G Salles, P J T A Groenen, P Gameiro, Ch Pott, J J M van Dongen
Journal: Leukemia (2006)
The therapeutic effect of histone deacetylase inhibitor PCI-24781 on gallbladder carcinoma in BK5.erbB2 mice
Authors: Takuya Kitamura, Kevin Connolly, Lynnsie Ruffino, Tetsuo Ajiki, Aline Lueckgen, John DiGiovanni, Kaoru Kiguchi
Journal: Journal of Hepatology (2012)
Abnormal Pulmonary Granuloma Formation in Osteopontin-deficient Mice
Authors: ANTHONY W. O'REGAN, JASON M. HAYDEN, STEVEN BODY, LUCY LIAW, NIALL MULLIGAN, MARGO GOETSCHKES, JEFFREY S. BERMAN
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Osteopontin is a novel cytokine that is expressed in pulmonary granulomatous disease such as sarcoidosis and tuberculosis. It can regulate macrophage and T cell migration, activation, and cytokine expression, yet its role in granuloma formation and evolution is unknown. We induced hypersensitivity pulmonary granulomas by embolizing Schistosoma mansoni eggs to the lungs of osteopontin-deficient (null mutant) mice and osteopontin-sufficient (wild-type control) mice. Granulomas from osteopontin-null animals were smaller at early time points and contained remarkably few macrophages and macrophage-derived epithelioid cells and giant cells. T cell accumulation was unaffected by osteopontin deficiency. These results demonstrate that osteopontin regulates macrophage accumulation during pulmonary granuloma formation, and may explain the impaired ability of osteopontin-deficient hosts to control mycobacterial disease.
Mediterranean Diet Inversely Associated With the Incidence of Metabolic Syndrome: the SUN Prospective Cohort
Authors: Miguel A. Martínez-González, Arancha Tortosa, Francisco Javier Basterra-Gortari, Maira Bes-Rastrollo
Journal: Diabetes Care (2008)

We appreciate the comments raised by Giugliano, Ceriello, and Esposito (1) on our study (2). When we wrote that participants in the highest score of the Mediterranean food pattern had lower levels of risk factors, we meant in terms of comparisons between extreme values (score = 0 vs. score = 9), not grouped categories (as shown in Table 1 of our study). Average levels of factors (all of them considerably below the cut-off point for the metabolic syndrome) across grouped …
Occupational dermatitis related to chromium and cobalt: experience of dermatologists (EPIDERM) and occupational physicians (OPRA) in the U.K. over an 11-year period (1993?2004)
Authors: P. Athavale, K.W. Shum, Y. Chen, R. Agius, N. Cherry, D.J. Gawkrodger
Journal: British Journal of Dermatology (2007)

Chromium and cobalt (and their compounds) are well recognized as being important causes of occupational contact dermatitis (OCD), particularly of the hands, although their exact contribution to occupational hand dermatitis varies between different studies. In some European studies, cases of chromium-related dermatitis have decreased following the addition of ferrous sulphate to cement to reduce the amount of available chromium.To examine, using data from the U.K. occupational skin surveillance schemes, the proportionate reported incidence and changing trends in OCD considered to be related to chromium and cobalt for the 11-year period from February 1993 to December 2004.Surveillance data collected by the two British occupational health surveillance schemes, EPIDERM and OPRA, from February 1993 to December 2004 were studied. These are occupational health surveillance schemes in the U.K. to which physicians voluntarily and anonymously report new cases of skin disease suspected to be work related.Over the 11-year period, dermatologists reported 22 184 cases of OCD, comprising 77% of all types of occupational skin diseases that were disclosed. Chromium was recorded as being thought to play a role in 1226 (6%) of these, with cobalt identified as being likely to be implicated in 823 (4%). The numbers fluctuated on a year-on-year basis but there were no overall trends during the period of study. The male/female ratio was 5 : 1 for chromium and 1 : 1 for cobalt. Overall, the male/female ratio for OCD was 1.4 : 1. The rates of dermatitis believed to be related to both metals generally increased with age. In women, the highest rate for chromium was seen in the > 60 years age group, whereas conversely, for cobalt the rate decreased with age. For chromium-related OCD the most common occupations were builders and building contractors, bricklayers, construction workers and plasterers. For cobalt-related OCD, the commonest occupations were hairdressers/barbers, builders/building contractors, retail cash/checkout operators, machine operatives and domestic cleaners. Occupational physicians reported 15 016 cases of OCD (82% of all occupational skin diseases reported by them) for the period May 1994-December 2004. Of these, only 38 cases were thought to be related to chromium and 30 to cobalt (25 of the latter were processing labourers).In this series, chromium was reported by dermatologists as potentially being involved in 6% of all cases of OCD in the U.K., and cobalt in 4%. Our data support the view that chromium-related dermatitis has an onset in later working life and often affects those in the building trades, whereas cobalt-related dermatitis seems to have an earlier onset and may affect a wide range of employments.