tbuckley/cabot-search huggingface dataset:
Paul Francis Dorian Naylor
Authors: C. P E Naylor
Journal: BMJ (2009)

Dr Paul F D Naylor, emeritus professor of dermatology at the University of London and former senior physician in the Department of Dermatology at St Thomas’ Hospital, died peacefully aged 84 on 9 May 2009 at a nursing home in Hingham, Norfolk, close to where he and his wife lived.

Paul Francis Dorian Naylor grew up in south Yorkshire, initially in Rotherham and later in the village of Laughton-en-le-Morthen on a small holding, for which he retained a deep affection. His parents, both schoolteachers, kindled his passions for learning, nature, gardening, photography, and woodwork. Besides being a headmaster, his father was a singer and conductor, so it was probably from him that Paul inherited a lifelong love of music.

Paul and his elder brother, Granville, went to Rotherham Grammar School. Inspired by visiting Granville at Cambridge, Paul was determined to follow his brother’s lead. It was a source of enormous family pride when Paul, like his brother, won a state scholarship to Gonville and Caius College in 1942. At Cambridge, Paul excelled academically, winning college prizes and in 1945 graduating with a double first class honours degree in medical sciences. The same year Paul began his clinical studies at St Thomas’s Hospital Medical School, qualifying as a doctor in 1948. His first appointments were at St Thomas’s Hospital, first as a casualty medical officer, and then as house physician to the …
ROLE OF THE PEDIATRICIAN IN PREVENTION OF NEEDLESS NEONATAL DEATHS
Authors: Stewart H. Clifford
Journal: JAMA (1953)

The pediatrician responsible for the newborn in an obstetric hospital has three major obligations. First, he must apply all available knowledge to the protection and care of his charges so that they may survive the hazards of this dangerous period of life without future handicaps. Secondly, he must strive, with the help of all allied disciplines, to extend the boundaries of present knowledge to the end that fetal and neonatal morbidity and mortality can be reduced. Thirdly, he must disseminate this special knowledge through every available medium so that babies everywhere may benefit. A revision of the American Academy of Pediatrics' manual "Standards and Recommendations for Hospital Care of Newborn Infants—Full Term and Premature" is about to be published 1 and should be made the bible of the newborn service. This manual contains standards that must be met by every hospital, irrespective of size or resources, attempting to care for
Left Ventricular Pacing Minimizes Diastolic Ventricular Interaction, Allowing Improved Preload-Dependent Systolic Performance
Authors: R.A. Bleasdale, M.S. Turner, C.E. Mumford, P. Steendijk, V. Paul, J.V. Tyberg, J.A. Morris-Thurgood, M.P. Frenneaux
Journal: Circulation (2004)

Left ventricular (LV) pacing improves hemodynamics in patients with heart failure. We hypothesized that at least part of this benefit occurs by minimization of external constraint to LV filling from ventricular interaction.We present median values (interquartile ranges) for 13 heart failure patients with LV pacing systems implanted for New York Heart Association class III/IV limitation. We used the conductance catheter method to measure LV pressure and volume simultaneously. External constraint was measured from the end-diastolic pressure-volume relation recorded during inferior vena caval occlusion, during LV pacing, and while pacing was suspended. External constraint to LV filling was reduced by 3.0 (4.6 to 0.6) mm Hg from 4.8 (0.6 to 7.5) mm Hg (P<0.01) in response to LV pacing; effective filling pressure (LV end-diastolic pressure minus external constraint) increased by 4.0 (2.2 to 5.8) mm Hg from 17.7 (13.3 to 22.6; P<0.01). LV end-diastolic volume increased by 10 (3 to 11) mL from 238 (169 to 295) mL (P=0.01), whereas LV end-systolic volume did not change significantly (-1 [-2 to 3] mL from 180 [124 to 236] mL, P=0.97), which resulted in an increase in stroke volume of 11 (5 to 13) mL from 49 (38 to 59) mL (P<0.01). LV stroke work increased by 720 (550 to 1180) mL . mm Hg from 3400 (2110 to 4480) mL . mm Hg (P=0.01), and maximum dP/dt increased by 120 (2 to 161) mm Hg/s from 635 (521 to 767) mm Hg/s (P=0.03).This study suggests a potentially important mechanism by which LV pacing may produce hemodynamic benefit. LV pacing minimizes external constraint to LV filling, resulting in an increase in effective filling pressure; the consequent increase in LV end-diastolic volume increases stroke volume via the Starling mechanism.
Rhabdomyolysis
Authors: Thomas D. Wooldridge
Journal: JAMA (1978)

HYPOPHOSPHATEMIA may result in a number of pathologic conditions. Fuller et al<sup>1</sup>have called attention to the fact that rhabdomyolysis may be precipitated by hypophosphatemia, particularly when accompanied by strenuous muscle work. In our patient, severe hypophosphatemia occurred secondary to parathyroidectomy and calcium replacement, resulting in an episode of rhabdomyolysis. Parathyroidectomy is frequently required by patients receiving longterm hemodialysis for control of renal osteodystrophy. To the best of our knowledge, rhabdomyolysis has not previously been reported as a complication of parathyroidectomy and calcium supplementation. <h3>Report of a Case</h3> A 33-year-old woman receiving long-term hemodialysis was admitted to the University of Mississippi Medical Center on March 27, 1977, for parathyroidectomy. Membranous glomerulonephritis was diagnosed in 1959, requiring long-term hemodialysis in June 1973. Her course was complicated by severe hypertension, and in October 1973 she underwent a bilateral nephrectomy for uncontrollable hypertension. During the patient's dialysis course, her serum inorganic phosphorus
NEW ORAL ANTICOAGULANTS AND GASTROINTESTINAL BLEEDING: INSIGHTS FROM META-ANALYSES AND TRIAL SEQUENTIAL ANALYSES OF RANDOMIZED CLINICAL TRIALS
Authors: Partha Sardar, Saurav Chatterjee, James DiNicolantonio, Jrn Wetterslev, Christian Gluud, Sripal Bangalore
Journal: Journal of the American College of Cardiology (2014)
Safety of Atrial Defibrillation Shocks Synchronized to Narrow and Wide QRS Complexes During Atrial Pacing Protocols Simulating Atrial Fibrillation in Dogs
Authors: Edward T. Keelan, David Krum, John Hare, Kashef Mughal, Huagui Li, Masood Akhtar, Mohammad R. Jazayeri
Journal: Circulation (1997)

Background The potential ventricular proarrhythmic effect of atrial defibrillation shocks (ADS) remains a concern with automatic internal atrial defibrillation. Optimal R-wave synchronization alone may not be sufficient to prevent the induction of ventricular fibrillation (VF). Methods and Results The proarrhythmic effect of ADS synchronized to normally conducted QRS complexes (NQRS) and to supraventricular complexes with left or right bundle-branch block (L/RBBB) was investigated in a canine atrial pacing study. Short-long-short, single premature, and burst pacing protocols from the high right atrium were performed at baseline, during isoproterenol infusion, and after intravenous procainamide. The ADS were delivered between decapolar catheters in the coronary sinus and lateral right atrium. They were initially delivered 20 milliseconds (ms) after the end of the last conducted QRS complex and then scanned decrementally through that complex until VF was induced. For NQRS complexes, VF occurred only when the ADS were delivered at or before the onset of the QRS complex and never during the complex itself. In the presence of LBBB or RBBB, VF was induced by ADS delivered at the onset of or within the first 45 ms of the QRS complex in 16 animals. The longest RR (VV) intervals preceding ADS-induced VF were 345 ms at baseline and 380 ms after procainamide. Conclusions In this study, ADS synchronized to NQRS complexes appeared to be safe regardless of the preceding RR interval. In the presence of LBBB or RBBB, RR intervals preceding the ADS of &gt;345 ms at baseline and &gt;380 ms in the presence of procainamide would have been required to avoid VF. Alternatively, ADS delivered 50 ms after the onset of the RV electrogram appeared to be safe in all circumstances regardless of the preceding RR interval.
HID and KID syndromes are associated with the same connexin 26 mutation
Authors: M. Van Geel, M.A.M. Van Steensel, W. Kuster, H.C. Hennies, R. Happle, P.M. Steijlen, A. Konig
Journal: British Journal of Dermatology (2002)

Summary Background Keratitis–ichthyosis–deafness (KID) syndrome is a debilitating ectodermal dysplasia that predisposes patients to develop squamous cell carcinomas in addition to leading to profound sensory deafness and erythrokeratoderma. We recently demonstrated that KID can be caused by a specific missense mutation in connexin 26 (GJB2). Another syndrome, called hystrix-like ichthyosis–deafnesss (HID) syndrome, strongly resembles the KID syndrome. These disorders are distinguished mainly on the basis of electron microscopic findings. We hypothesized that KID and HID syndromes may be genetically related. Objective To demonstrate by mutation analysis that HID and KID syndromes are genetically indistinguishable. Methods DNA was extracted from paraffin-embedded tissue samples of the first HID syndrome patient described in the literature. Since the KID syndrome mutation abolishes an AspI restriction site, we were able to screen the patient's DNA by polymerase chain reaction and subsequent restriction enzyme analysis. Results Restriction analysis of the connexin 26 gene in HID syndrome demonstrated the presence of the KID syndrome mutation that we previously described. This result was confirmed by direct DNA sequencing. Conclusions We show that KID and HID syndromes are identical at the molecular level and confirm the clinical impression that these syndromes are one and the same. That previous clinical reports made a distinction may be a consequence of sampling artefacts; alternatively, genetic background effects such as the presence of concurrent mutations in other skin-expressed genes may modify the phenotype.
Charter for General Practice — Cost of Hospital Building — Drug-Industry Inquiry — Exploits of Goldie
Authors: John Lister
Journal: New England Journal of Medicine (1965)

THE dispute between the general practitioners and the Government has not yet been resolved, but a three-month truce appears to have been declared during which negotiations can take place.After the British Medical Association had rejected the recommendation of the Review Body that would have granted an additional £5,500,000 to the central pool on condition that the money was distributed to doctors providing the best office accommodations and secretarial services the Minister asked the Review Body to clarify certain points. The result was a revised recommendation that the £5,500,000 should be granted unconditionally. This concession led to a relaxation of . . .
Teacher launches case against primary care trust over refusal to pay for treatment
Authors: C. Dyer
Journal: BMJ (2009)

A trainee teacher with primary refractory Hodgkin’s lymphoma has launched a High Court action against her primary care trust, NHS Surrey, which has refused to pay for her treatment with an unlicensed drug.

Philippa Bigham, aged 28, from Frimley, Surrey, has been given a prognosis of two years’ survival without a bone marrow transplantation. But her medical team at the …
PSYCHIATRIC, COMMUNITY AND RACIAL INTEGRATION IN A GENERAL HOSPITAL
Authors: HAROLD H. MORRIS, KENNETH E. APPEL, JOHN L. PROCOPE
Journal: American Journal of Psychiatry (1963)

A description of 5 years' experience involving a cooperative effort is presented. The chief cooperating agencies involved are the State and City governments, a community general hospital, and the Department of Psychiatry of a large university. This cooperation has worked rather smoothly with some administrative problems. Integrating a large psychiatric service in a community general hospital has not worked smoothly. Community-hospital cooperation has proceeded, but can be developed much more extensively. Race relationships within the Department of Psychiatry have been the subject of special scrutiny, and the results of a pilot survey in this area are given. This preliminary survey has included some of the social and diagnostic characteristics of the patient population, and ways in which patients are treated psychiatrically. These figures are presented in terms of race and sex as applied to patients selected for intensive psychotherapy, electroshock, transfers to other hospitals, outpatient clinic referrals, discharges against medical advice, readmissions to the service, and length on the service.
Magnetic Resonance–Based Assessment of Global Coronary Flow and Flow Reserve and Its Relation to Left Ventricular Functional Parameters
Authors: J. Schwitter, T. DeMarco, S. Kneifel, G. K. von Schulthess, M. Ciopor Jörg, Hakan Arheden, S. Rühm, K. Stumpe, A. Buck, W. W. Parmley, T. F. Lüscher, C. B. Higgins
Journal: Circulation (2000)

Background —Measurement of coronary sinus blood flow (CSF) by phase-contrast magnetic resonance (PC-MR) imaging at rest and during hyperemia may allow noninvasive assessment of global coronary hemodynamics. Methods and Results —Sixteen healthy volunteers (age, 22 to 32 years) were examined with MR and PET in random order within 1 to 2 days. At rest and during hyperemia (dipyridamole 0.56 mg/kg), CSF was measured by a cine PC-MR technique (temporal resolution, 40 ms; spatial resolution, 1.25×0.8 mm 2 ), and myocardial blood flow (MBF) was measured by [ 13 N]NH 3 PET. PET and MR agreed closely for coronary flow reserve (CFR; mean difference, 2.2±14.7%; Bland-Altman method). CSF divided by either total left ventricular mass or an estimate of drained myocardium (LVM drain ) correlated highly with PET flow data ( r =0.93 and 0.95, respectively) and with measures of oxygen demand, ie, heart rate, afterload-corrected fiber shortening, and peak systolic stress determined by MR (overall correlation coefficients, 0.81 and 0.87, respectively, multivariate analysis). CSF/LVM drain did not differ significantly from PET-derived MBF (difference, 3.6±16.6%). In orthotopic heart transplant recipients (n=9), CFR was reduced and blood supply-demand relationships at rest were shifted toward higher flows ( P &lt;0.0001). Conclusions —This integrated MR approach allows comprehensive assessment of autoregulated and hyperemic coronary flow and is suitable for serial measurements in patients. In transplanted hearts, elevated resting flow is the major cause of reduced CFR.
Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients
Authors: Fabienne Venet, Chun-Shiang Chung, Hakim Kherouf, Anne Geeraert, Chistophe Malcus, Françoise Poitevin, Julien Bohé, Alain Lepape, Alfred Ayala, Guillaume Monneret
Journal: Intensive Care Medicine (2008)
"Invalidity" due to chronic bronchitis and emphysema: how real is it?
Authors: S J Pearce, V Posner, A J Robinson, J R Barton, J E Cotes
Journal: Thorax (1985)

Hospital discharges and deaths attributed to chronic bronchitis and emphysema have fallen in recent years while the number of those receiving invalidity benefit for these conditions has remained constant. One hundred and fifty seven such persons were invited to take part in this study, in which the diagnosis, degree of respiratory impairment, and other factors contributing to disability were reviewed. The scope for rehabilitation was considered. One hundred subjects agreed to take part; 96 were men and 70 were over 60 years. In only 67 was the main diagnosis chronic bronchitis and emphysema. There was a bimodal distribution of functional impairment, most being severely disabled, but in 20 the FEV1 was within the normal range. Among these asthma was more common and psychological factors were important. Economic factors contributed to "invalidity," especially among those with a normal FEV1. For 32 of the 57 who had declined to take part some information was available from hospital records. The findings in this group were similar. There was little scope for rehabilitation in the group as a whole as motivation was poor. Less than half had ever seen a chest physician. Specialist assessment before invalidity benefit is claimed is probably desirable.
New uncertainties in prenatal screening for neural tube defect.
Authors: R Harris, A P Read
Journal: BMJ (1981)

and increasing numbers of students denied university places, no arguments can justify spending £15m of public money in this way, to say nothing of the appalling wastage of more than l1Om of valuable assets at Charterhouse Square.To behave with such reckless abandon at this time of crisis within the universities of this country is surely immoderate.
Cardiac Performance After Diagnostic Coronary Arteriography
Authors: SHAHBUDIN H. RAHIMTOOLA, GERALD T. GAU, MAURICE J. RAPHAEL
Journal: Circulation (1970)

Cardiac performance was assessed before and after diagnostic coronary arteriography in 19 patients with heart disease. There was no significant change in cardiac output, heart rate, stroke volume, hemoglobin, hematocrit, and mean systemic arterial pressure. Left ventricular (LV) filling pressure and mean pulmonary artery pressure increased temporarily. The increased left ventricular filling pressure was accompanied by an increase of LV work performed in a few patients; in the remainder the left ventricle performed less work. In four dogs, selective left coronary arteriography resulting in increased ventricular filling pressure, was accompanied by an increase of left ventricular end-diastolic (V ED ) and stroke volumes; the ejection fraction and heart rate remained unchanged. If the animal studies (increased V ED accompanying increased ventricular filling pressure) can be applied to patients with heart disease, the alteration of left ventricular function can be considered on the basis of the Frank-Starling mechanism. To cope with the temporary depression of its function, the left ventricle of patients with heart disease utilized the Frank-Starling mechanism resulting in an adequate (essentially unchanged) cardiac output from an increased left ventricular filling pressure. The normal left ventricle of the dog, stressed more than is appropriate clinically, shows an increased stroke volume accompanying the increased end-diastolic volume.
Type 1 Diabetes and Arterial Dysfunction in Asymptomatic Chinese Adults
Authors: Kam S. Woo, Ping Chook, Wing B. Chan, Woon Y. So, Clive S. Cockram, David S. Celermajer
Journal: Diabetes Care (2001)

Lettersnondiabetic siblings of type 1 diabetic patients and therefore correlated with plasma concentrations of Lp(a) and fibrinogen.Cases of hyponatremia have been correlated with inflammation ( 14) and increased plasma interleukin Ϫ6 concentration (15).These findings are consistent with our hypothesis of an association among inflammatory markers, oxidative stress, and susceptibility to type 1 diabetes.Moreover, the familiarly overactive NHE could be viewed independently as further evidence for the presence in these families of a redox disequilibrium in which oxidation seems to be dominant.
Myasthenia and Prostaglandin E_1
Authors: DAVID F. HORROBIN
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 April 1979Myasthenia and Prostaglandin E1DAVID F. HORROBIN, M.A., D.PHIL., B.M.DAVID F. HORROBIN, M.A., D.PHIL., B.M.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-4-719_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I was interested in the report of a myastheriialike syndrome induced by penicillamine (1) in the December 1978 issue. The rapid onset and reversal were particularly striking.My group has recently shown that penicillamine stimulates the formation of material with the properties of prostaglandin E1 (2, 3). Prostaglandin E1 infusion into humans rapidly produces subjective and objective muscle weakness, reversed on stopping the infusion. There is some evidence that an allosteric site at the acetyl choline receptor on the electric organ may be occupied by a prostaglandin (4).Prostaglandin E1seems to be a highly potent stimululator...References1. ATCHESONWARD SJ: Ptosis and weakness after start of D-penicillamine therapy. Ann Intern Med 89:939-940, 1978 LinkGoogle Scholar2. CUNNANEZINNERHORROBINMANKU SHDM: Copper inhibits responses to noradrenaline but not potassium. Interactions with prostaglandins E1, E(q), I, and penicillamine. Can J Physiol Pharmacol, in press. Google Scholar3. HORROBIN D: Prostaglandins: Physiology, Pharmacology and Clinical Significance. Montreal, Eden Press, 1978, p. 144 Google Scholar4. HORROBINMANKUALLYMORGANKARMALI DMARR: Quinacrine as a prostaglandin antagonist. Biochem Biophys Res Comm 76:1188-1193, 1977 CrossrefMedlineGoogle Scholar5. ZURIER R: Prostaglandins, inflammation and immune responses. Prostaglandins Ther 5:1-2, 1979 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Institut de Recherches Cliniques de Montréal Montréal, PQ H2W 1R7, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMiastenia grave induzida por D-penicilamina em paciente com esclerose sistêmica progressivaPenicillamine-induced myasthenia gravis in progressive systemic sclerosisMyotonic dystrophy: A disease caused by functional zinc deficiency due to an abnormal zinc-binding ligand? 1 April 1979Volume 90, Issue 4Page: 719-719KeywordsMusclesProstaglandin Issue Published: 1 April 1979 PDF DownloadLoading ...
Manifestation of atopy is not related to patient's month of birth
Authors: T. Schafer, B. Przybilla, J. Ring, B. Kunz, A. Greif, K. Überla
Journal: Allergy (1993)

The first months of life may be an important period for allergic sensitization. Several studies suggest a relationship between the month of birth (MB) and the development of skin sensitivity to aeroallergens or the manifestation of an atopic disease. In 1988 and 1989 we investigated a population of 1066 Bavarian preschool children aged 5-6 years. Skin prick tests were performed with common aeroallergens (grass pollen, birch pollen, house-dust mite, cat epithelia). The personal history of atopic disease (atopic eczema, allergic rhinitis, bronchial asthma) was recorded by a questionnaire, and the presence of overt atopic disease was documented by a personal examination. Positive prick test reactions to the above-mentioned aeroallergens were found in 15.4%, 9.2%, 12.2%, and 10.4% of the subjects, respectively; lifetime prevalence of manifest atopic disease was 22.2% for atopic eczema, 11.7% for allergic rhinitis, and 4.5% for asthma. The MB distributions of children reacting to aeroallergens or of those with atopic diseases were compared with those of subjects with corresponding negative findings. Chi-square tests were performed for each aeroallergen and each of the atopic diseases separately. No significant differences among the MB distributions were found (P > 0.3). Thus, in this coherent group, MB correlated neither to allergic sensitization nor to manifest atopic disease.
TIME AND COST EFFECTIVENESS OF SEPARATE ACQUISITION REST THALLIUM STRESS TECHNETIUM SESTAMIBI DUAL ISOTOPE MYOCARDIAL PERFUSION SPECT: COMPARISON TO SINGLE ISOTOPE SPECT IMAGING USING EITHER THALLIUM OR TECHNETIUM SESTAMIBI
Authors: G Silagan, H Kiat, K Van Train, M Hyun, J Friedman, DS Berman
Journal: Clinical Nuclear Medicine (1993)