tbuckley/cabot-search huggingface dataset:
Glycosylation of CD44 negatively regulates its recognition of hyaluronan.
Authors: S Katoh, Z Zheng, K Oritani, T Shimozato, P W Kincade
Journal: The Journal of Experimental Medicine (1995)

Although CD44 is expressed on a wide variety of cell types, few of them use it to recognize the ligand hyaluronan (HA). A glycosylation-defective clone of Chinese hamster ovary cells (Lec 8) bound HA, demonstrating that complete processing of glycoproteins with addition of a full complement of sialic acid is not required. On the contrary, subsequent findings revealed that complex sugars on CD44 can actually inhibit ligand recognition. Two subclones of wild-type Chinese hamster ovary cells with similar amounts of surface CD44 were isolated on the basis of HA binding and found to differ with respect to CD44 size as well as staining with fluorescent lectins. Treatment of the nonbinding clone with tunicamycin reduced the size of the protein and allowed the cells to recognize HA via CD44. This function was also induced by treatment with deglycosylating enzymes (either a mixture of endoglycosidase F and N-glycosidase F or neuraminidase alone). A possible role for glycosylation in regulation of adhesion was then sought with a series of normal and transformed murine cells. Disruption of glycosylation or treatment with deglycosylating enzymes did not induce ligand binding in an interleukin 7-dependent pre-B cell line, and splenic B cells also appeared to be in an inactive state. Some normal B cells acquired the ability to recognize HA after stimulation with lipopolysaccharide or interleukin 5 and had distinctive surface characteristics (loss of immunoglobulin D and acquisition of CD43). An additional subset of activated cells might have been in a transitional state, because the cells bound ligand after neuraminidase treatment. The ligand-binding ability of a purified CD44-immunoglobulin fusion protein dramatically increased after neuraminidase treatment. Thus, differential glycosylation of this molecule is sufficient to influence its recognition function. Cell adhesion involving HA can be regulated by multiple mechanisms, one of which involves variable glycosylation of CD44.
GW25-e5175 Point-of-care sensitive cardiac troponin I in the rapid triage of chest pain patients in emergency department
Authors: Ye Zi, Huang Ying-Xiong, Zheng Zi-Yu, Zhan Hong, Xu Jia, Jiang Peng, Liao Xiao-Xing, Li Xin
Journal: Journal of the American College of Cardiology (2014)
751. Magnetic Microbubbles: New Carriers for Localized Gene and Drug Delivery
Authors: Dialekti Vlaskou, Olga Mykhaylyk, Riccardo Giunta, Iva Neshkova, Nicole Hellwig, Florian Kroetz, Christian Bergemann, Christian Plank
Journal: Molecular Therapy (2006)

In order to overcome limitations to gene delivery and therapy associated with insufficient vector accumulation at target sites and to increase drug targeting efficiency, we combined the advantages of magnetic drug targeting with microbubble technology. Microbubbles are currently used clinically as contrast agents in ultrasound (US) diagnostics and experimentally as drug or nucleic acid carriers. Localized delivery, drug release and tissue penetration can be achieved by local application of ultrasound leading to microbubble disruption. We have developed perfluoropropane-filled microbubbles containing a high load of superparamagnetic nanoparticles along with an active agent (nucleic acid or drug) in a lipid or denatured albumin shell. For this purpose, magnetic nanoparticles with suitable surface coatings, such as detergents, are required. The magnetic retention of the bubbles at a given flow rate is tremendously improved compared to the same quantity of magnetic nanoparticles in suspension. In cell culture, magnetic microbubbles are sedimented on target cells by magnetic force and bubble disruption and gene delivery is triggered by the application of US of 1 MHz. Biodistribution experiments upon tail vein injection in mice demonstrated the highest nucleic acid deposition when a magnetic field was applied to a target area such as a lung lobe in combination with ultrasound. Similarly, using a dorsal skin chamber model in mice and intravital fluorescence microscopy, we have demonstrated the localized delivery of plasmid DNA, synthetic antisense oligonucleotides and siRNA to the vasculature and surrounding tissue within the chamber by applying a suitable magnetic gradient field to the target area in combination with US. Without magnetic field or US application, no localized delivery was feasible. We have demonstrated the therapeutic potential of the technique with subcutaneous administration of magnetic microbubbles carrying the VEGF gene in a skin flap model. The combination of magnetic field and ultrasound yielded the highest blood perfusion and tissue survival of the skin flap area in comparison to controls with reporter genes or with the VEGF gene in the absence of magnetic field and/or ultrasound. Our results indicate that magnetic microbubbles are highly promising drug carriers that can be remote-controlled within the blood circulation by two independent physical forces. Magnetic microbubbles loaded with appropriate agents can considerably improve drug deposition and the site specificity of delivery. In particular, magnetic microbubbles may offer a combination of therapeutic intervention with molecular imaging (US diagnostics, MRI).
Revisiting the Revisited Football Team Hepatitis Outbreak
Authors: Gary N. Fox
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Friedman et al<sup>1</sup>assume that lack of IgM antibody to hepatitis A virus (anti-HAV) excludes acute infection with this virus. In their comments, the authors attempt to reconcile their new data with the old, but do not include as a possibility that some individuals developed acute hepatitis A virus infections without detectable IgM anti-HAV. Indeed, the results clearly indicate that two team members whose initial IgG anti-HAV test results were negative later developed persistent IgG anti-HAV without demonstrating detectable IgM anti-HAV. In addition, another 11 subjects, whose initial IgG anti-HAV was undetectable, and who never exhibited IgM anti-HAV, demonstrated positive IgG anti-HAV "on the only or last determination." While these individuals may have had transient IgG due to administration of immune globulin, we are not told the duration of IgG persistence. Based on the data presented, these cases might also represent HAV infections (with IgG seroconversion)
Immunoglobulin M Type of Autoantibodies to Oxidized Low-Density Lipoprotein Has an Inverse Relation to Carotid Artery Atherosclerosis
Authors: Jarkko Karvonen, Markku Päivänsalo, Y. Antero Kesäniemi, Sohvi Hörkkö
Journal: Circulation (2003)

Background— Lipoprotein oxidation plays an important part in atherogenesis. Autoantibodies to oxidation-specific epitopes of LDL occur in plasma and atherosclerotic lesions of humans and animals. The potential role of these autoantibodies in atherogenesis still remains unsolved. We studied the relationship between different isotypes of autoantibodies to copper-oxidized LDL and malondialdehyde-modified LDL (MDA-LDL) and carotid artery intima-media thickness (IMT) in a population-based cohort of 1022 middle-aged men and women. In addition, we studied the relation of C-reactive protein (CRP) to IMT. Methods and Results— The levels of IgM, IgG, and IgG2 autoantibodies binding to MDA-LDL and copper-oxidized LDL were determined in plasma samples by chemiluminescence-based ELISA. IMT and the number of plaques were measured ultrasonographically. The subjects were divided into tertiles for antibody titers. We found an inverse association between IMT and IgM autoantibody titers to MDA-LDL that remained statistically significant after adjusting for age, gender, LDL cholesterol, systolic blood pressure, CRP, and smoking. CRP was not independently associated with IMT. Conclusions— These results show that IgM autoantibodies to MDA-LDL have an inverse association with carotid atherosclerosis. The possible implications of this finding are discussed.
Respiratory symptoms in older people and use of domestic gas appliances
Authors: L Dow, L Phelps, L Fowler, K Waters, D Coggon, S T Holgate
Journal: Thorax (1999)

<h3>BACKGROUND</h3> Studies in children and young women have indicated an increased risk of respiratory illness in association with the use of domestic gas appliances, possibly caused by oxides of nitrogen generated when gas is burned. It is not known whether risks are similarly increased in older subjects. <h3>METHODS</h3> A questionnaire about respiratory symptoms in the past year and potential risk factors for respiratory disease was mailed to 6000 men and women aged 65 years and older who were selected at random from the lists of general practices in North Bristol, UK. Associations between symptoms and the use of gas appliances were examined by logistic regression with adjustment for age, sex, social class, and smoking habits. <h3>RESULTS</h3> Questionnaires were completed by 4792 (80%) of those mailed. The most common symptoms were exercise induced breathlessness, wheeze, or chest tightness (51%); wheeze (27%); morning phlegm (20%); and daytime breathlessness at rest (19%). In an analysis that included all subjects only weak associations were found with use of gas appliances, odds ratios all being 1.2 or less. The risks associated with use of a gas hob tended to be higher in women, with odds ratios of 1.36 (95% CI 1.01 to 1.83) for wheeze and 1.33 (95% CI 0.56 to 3.17) for morning chest tightness, but were lower than had been reported previously in younger women. <h3>CONCLUSION</h3> The absence of stronger associations cannot readily be explained by bias or confounding. Gas cookers and fires are unlikely to be an important cause of respiratory illness in the elderly. If they do cause such illness, the largest risks are likely to be in women who use gas hobs.
IL-7 and IL-15 allow the generation of suicide gene–modified alloreactive self-renewing central memory human T lymphocytes
Authors: Shin Kaneko, Sara Mastaglio, Attilio Bondanza, Maurilio Ponzoni, Francesca Sanvito, Luca Aldrighetti, Marina Radrizzani, Simona La Seta-Catamancio, Elena Provasi, Anna Mondino, Toshiro Nagasawa, Katharina Fleischhauer, Vincenzo Russo, Catia Traversari, Fabio Ciceri, Claudio Bordignon, Chiara Bonini
Journal: Blood (2008)
Family Care of the Insane.
Authors: Geo. P. Sprague
Journal: JAMA (1903)

Lexington, Ky., March 16, 1903. <h3>To the Editor:</h3> —Your editorial in the last number ofThe Journal, on family care of the harmless insane, leads me to suppose that you do not know that it has been continuously in use in Massachusetts since 1885. It was due, I believe, to the efforts of Dr. Henry R. Stedman of Boston, who wrote a most exhaustive paper on the subject. The matter was reviewed at the last meeting of the American Medico-Psychological Association.
Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer
Authors: Robert Gryfe, Hyeja Kim, Eugene T.K. Hsieh, Melyssa D. Aronson, Eric J. Holowaty, Shelley B. Bull, Mark Redston, Steven Gallinger
Journal: New England Journal of Medicine (2000)

Colorectal cancer can arise through two distinct mutational pathways: microsatellite instability or chromosomal instability. We tested the hypothesis that colorectal cancers arising from the microsatellite-instability pathway have distinctive clinical attributes that affect clinical outcome.
Closing In on Polio
Authors: Joan Stephenson
Journal: JAMA (2001)

A global effort to eradicate poliomyelitis by 2005 is 99% complete, according to new figures released by the Global Polio Eradication Initiative. Fewer than 3500 cases were reported in 2000, down from the estimated 350 000 annual cases in 1988, when the program began.
Vascular Access in Patients Receiving Hemodialysis
Authors: Raymond J. Tesi
Journal: JAMA (1997)

To the Editor.  —The article on vascular access by Hirth et al1and the Editorial by Chertow2suggest that surgeons and nephrologists are not serving the best interests of their patients by the excessive use of polytetrafluoroethylene (PTFE) grafts in creating vascular access for chronic hemodialysis. We agree that physicians exert a critical influence on the choice of an AVF over a PTFE graft. Hirth et al1calculate that 25% of surgeons accounted for 95% of all AVFs. Unfortunately, the critical statistic needed to support their
Creutzfeldt–Jakob Disease in a Young Adult with Idiopathic Hypopituitarism
Authors: T K Koch, B O Berg, S J De Armond, R F Gravina
Journal: New England Journal of Medicine (1985)

Medical Intelligence from The New England Journal of Medicine — Creutzfeldt–Jakob Disease in a Young Adult with Idiopathic Hypopituitarism — Possible Relation to the Administration of Cadaveric Human Growth Hormone
UK study reveals double the risk of ill health in Gulf war veterans
Authors: S. Mayor
Journal: BMJ (1999)

British soldiers who served in the 1991Gulf war have reported twice the rate of illness as control groups who served elsewhere, according to the largest epidemiological study into the issue (Lancet 1999;353:169-78, 179-82). But the range of symptoms reported—including headache, fatigue, asthma, and arthritis—was similar between the groups, leading researchers to conclude that going to the Gulf did not lead to a specific illness.

The study compared responses to detailed questionnaires that were sent to 4250servicemen who served in the Gulf war with those from two …
Mortality higher at for-profit hospitals
Authors: J. H. Tanne
Journal: BMJ (2002)

Patients in for-profit hospitals in the United States are more likely to die than those in non-profit hospitals, a new systematic review and meta-analysis says. The study, by researchers at McMaster University in Hamilton, Ontario, and the University of Buffalo, New York, has been published in the Canadian Medical Association Journal (2002;166:1399-406).

Besides the implications for the United States, the study fuels debate in Canada over whether private, for-profit hospitals should be allowed to enter the marketplace in an overhaul of Canada's national health insurance plan. The Commission on the Future of …
More on Dietary Sodium and Blood Pressure-Reply
Authors: Alexander G. Logan
Journal: JAMA (1997)

<h3>In Reply.</h3> —Dr Stamler and colleagues state that we made several factually incorrect statements in our letter to<i>JAMA</i>, which was written in response to letters commenting on our recent meta-analysis of randomized controlled trials of dietary sodium restriction. They cite examples of errors based on information contained in articles that were not yet published at the time our meta-analysis and our letter were published, and then conclude incredulously that our viewpoint is biased. Our comment on the Intersalt study results stems from statements made in the 1988 article.<sup>1</sup>For example, the original Intersalt report states that there was no relationship between median sodium excretion and prevalence of hypertension when the 4 geographically isolated populations were excluded.<sup>1</sup>We can only take such statements at face value. The critical point in TOHP surely is the primary prevention of hypertension by dietary means rather than changes in BP at selected intervals; this
Effectiveness of the particle repositioning maneuver for benign positional vertigo following traumatic brain injury
Authors: Donna Ouchterlony, Alicja Michalak, Jane Topolovec-Vranic, John A Rutka, Cheryl Masanic
Journal: British Journal of Sports Medicine (2013)

Objective The purpose of this pilot project was to explore the clinical presentation of benign positional vertigo (BPV) in patients with mild or moderate traumatic brain injury (TBI) and to determine if a non-invasive bedside intervention, the Particle Repositioning Maneuver (PRM) would be effective in treating BPV. Design Observational, cohort prospective study, with repeated measures of three groups of patients diagnosed with TBI. Setting Subjects were recruited from an out-patient clinic specialising in the management of TBI in a large, urban, academic hospital. Participants 56 subjects with mild to moderate TBI: 21 patients with BPV, 23 with non-specific dizziness, and 12 without any form of dizziness. Intervention Patients were assessed at baseline and at 1, 5, 9 weeks and 3 months post-enrollment. BPV was confirmed by the administration of the Dix-Hall Pike Maneuver to patients with dizziness at each assessment and those positive for BPV received PRM treatment. Outcome Measures Demographic and injury-related data were collected and the Dizziness Handicap Inventory (DHI) and Short-Form Health Survey (SF-36) were administered at each assessment. Mean difference in DHI scores between baseline and follow-ups were assessed. Results DHI scores were significantly reduced in the BPV group (20.6; p&lt;0.01) and dizziness symptoms had resolved in 52% of patients. A significant improvement on the SF-36 physical component scores was found for the BPV group (increasing from 38.1 at baseline to 45.7 at 3 months; p&lt;0.01) Conclusions Our pilot study demonstrated both significantly improved dizziness symptoms and physical wellbeing for BPV patients who received PRM treatment. Competing interests None.
Psoriasis, razoxane and a cutaneous B-cell lymphoma
Authors: R.B. MALLETT, J.A. LANGTRY, J.I. HARPER, R.C.D. STAUGHTON
Journal: British Journal of Dermatology (1987)

Journal Article Psoriasis, razoxane and a cutaneous B‐cell lymphoma Get access R.B. MALLETT, R.B. MALLETT Department of Dermatology, Westminster Hospital, London SW1, U.K. Dr R.B.Mallett. Search for other works by this author on: Oxford Academic Google Scholar J.A. LANGTRY, J.A. LANGTRY Department of Dermatology, Westminster Hospital, London SW1, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.I. HARPER, J.I. HARPER Department of Dermatology, Westminster Hospital, London SW1, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.C.D. STAUGHTON R.C.D. STAUGHTON Department of Dermatology, Westminster Hospital, London SW1, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 116, Issue 2, 1 February 1987, Pages 243–244, https://doi.org/10.1111/j.1365-2133.1987.tb05820.x Published: 01 February 1987
Further evidence for an association between psoriasis, Crohn's disease and ulcerative colitis
Authors: VICTORIA M.YATES, G. WATKINSON, A. KELMAN
Journal: British Journal of Dermatology (1982)

To test the hypothesis that psoriasis is associated with Crohn's disease and ulcerative colitis, 204 patients with inflammatory bowel disease (116 with Crohn's disease and 88 with ulcerative colitis) and 204 age and sex matched controls were interviewed and examined. The prevalance of psoriasis in Crohn's disease (II.2%) and in ulcerative colitis (5.7%), was significantly greater than in the control group (1.5%). The prevalence of psoriasis in first degree relatives of patients with inflammatory bowel disease was also increased. It is suggested that there is a relationship between psoriasis, ankylosing spondylitis, sacroiliitis, peripheral arthropathy and inflammatory bowel disease, which may be explained by common genetic factors.
Benign Tongue FDG Uptake in a Patient With Tardive Dyskinesia
Authors: Jeffrey M. Levsky, Nataraj Shanmugam, Suman Jana
Journal: Clinical Nuclear Medicine (2008)

Fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography (F-18 FDG PET-CT) is the modality of choice for diagnosis, staging, and restaging of many malignancies. The importance of eliminating false positives cannot be underestimated because they can dramatically alter the clinical course. We present a case of benign uptake in the tongue secondary to tardive dyskinesia in a 62-year-old woman referred for staging of ductal carcinoma of the breast who was concurrently receiving oral therapy for schizoaffective disorder. This case emphasizes the importance of direct clinical interview and adequate history taking in the formulation of an appropriate diagnosis.
506 THE RAS INHIBITOR FARNESYLTHIOSALICYLIC ACID INHIBITS THE GROWTH OF HEPATOCARCINOMA CELL LINES IN VITRO AND IN VIVO
Authors: N. Charette, V. Lannoy, C. De Saeger, I. Leclercq, Y. Horsmans, P. Stärkel
Journal: Journal of Hepatology (2009)
Getting research findings into practice: When to act on the evidence
Authors: T. A Sheldon, G. H Guyatt, A. Haines
Journal: BMJ (1998)

This is the second in a series of eight articles analysing the gap between research and practice Series editors: Andrew Haines and Anna Donald There is increasing interest in providing evidence based health care—that is, care in which healthcare professionals, provider managers, those who commission health care, the public, and policymakers consistently consider research evidence when making decisions. 1 2 Purchasers, for example, should be able to influence the organisation and delivery of care (such as for cancer3 and stroke services4) and the type and content of services (such as using chiropractic for back pain or dilatation and curettage and drug treatment for menorrhagia5). Policymakers should ensure that policies on treatment reflect and are consistent with research evidence, and that the incentive structure within the health system promotes cost effective practice. They must also ensure that there is an adequate infrastructure for monitoring changes in practice and for producing, gathering, summarising, and disseminating evidence. Clinicians determine the day to day care patients receive in healthcare systems, and user groups (for example, patients, their families, and their representatives) are also beginning to play an important role in influencing healthcare decisions.6 The factors described below should be considered when deciding whether to act on or promote the implementation of research findings. #### Summary points