tbuckley/cabot-search huggingface dataset:
The Prognosis of Essential Hypertension Treated Conservatively
Authors: MAURICE SOKOLOW, DOROTHEE PERLOFF
Journal: Circulation (1961)

Four hundred thirty-nine consecutive patients (143 men and 296 women) with essential hypertension were followed on conservative therapy for a minimum of 5 years or until death. The initial blood pressure taken by a standard method and the presence and degree of vascular involvement at the time of registration were recorded on all patients. On the basis of these observations, each patient was classified in one of four classes of over-all hypertensive severity. At the end of the 5-year follow-up period, 161 patients were dead, 78 men and 83 women. The higher mortality among men was significant and was apparent after the first year of follow-up. A progressive rise in 5-year mortality was observed with increasing degrees of initial blood pressure elevation, fundal involvement, cardiac size by radiogram, and electrocardiographic evidence of left ventricular hypertrophy, as well as with progressively higher classification of over-all hypertensive severity. Patients with mild hypertension and minimal cardiovascular impairment (class I) had an 11 per cent 5-year mortality, while patients with malignant hypertension, renal failure, or congestive heart failure (class IV) had an 84 per cent 5-year mortality. Early deaths in patients with mild hypertension were found to be largely due to atherosclerotic complications or noncardiovascular causes. Possible explanations for long survivals in patients with advanced vascular involvement on initial examination are discussed. The increased mortality of men over women was attributed in part to greater severity of disease on initial registration and in part to a higher incidence of coronary atherosclerosis. The mortality in patients with headache, dizziness, and nervous tension was found to be a factor of the associated vascular complication rather than of the symptoms alone. Patients with clinical obesity were found to have a lower over-all mortality than patients who were not obese. The prognostic value of a standardized initial blood pressure measurement is stressed and is discussed in the light of previous work by Perera, Smirk, and Gilchrist. The prognostic data were presented as a framework against which the long-term treatment of mild and moderate hypertension can be tested.
Early palliative care improved quality of life in patients with newly diagnosed metastatic NSCLC
Authors: Bob Arnold
Journal: Annals of Internal Medicine (2010)

ACP Journal Club21 December 2010Early palliative care improved quality of life in patients with newly diagnosed metastatic NSCLCBob Arnold, MDBob Arnold, MDUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA (B.A.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-12-201012210-02003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationTemel JS, Greer JA, Muzikansky A, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med. 2010;363:733-42. https://pubmed.ncbi.nlm.nih.gov/20818875Clinical Impact RatingsGIM/FP/GP: Hospitalists: Reference1 National Consensus Project. National Consensus Project for quality palliative care. www.nationalconsensusproject.org/ (accessed 13 Oct 2010). Google Scholar Author, Article, and Disclosure InformationAuthors: Bob Arnold, MDAffiliations: University of Pittsburgh, Pittsburgh, Pennsylvania, USA (B.A.)This article was published at Annals.org on 7 December 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEarly palliative care for patients with metastatic cancer 21 December 2010Volume 153, Issue 12Page: JC6-3KeywordsAnxietyChemotherapyHealth information technologyLung and intrathoracic tumorsNon small cell lung cancerPalliative carePatientsQuality of lifeSurvival analysis ePublished: 21 December 2010 Issue Published: 21 December 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
TREATMENT OF CARBUNCLE.
Authors: JOHN PHILLIPS
Journal: JAMA (1898)

TheJournalof Dec. 12, 1896, p. 1226, contained an article by W. E. Shaw, M.D., of Cincinnati, on the "Conservative Treatment for Carbuncle." My own observations have been so entirely different from the teachings of this article that I am constrained to make a most decided protest against this plan of no treatment, or next to none, of this most formidable disease. It was the fortune of the writer, in the autumn of 1865, to suffer from a large and most painful carbuncle, located centrally on the back, overlapping both scapulæ, which was aggravated by attending to professional duties for a week after the disease had made its appearance, not only at home but during the same time making three trips in a buggy a distance of twenty-two miles, returning home in the evening much chilled. By this time I was obliged to go to bed and remain there
Trends in Use of Implantable Cardioverter-Defibrillator Therapy Among Patients Hospitalized for Heart Failure
Authors: Sana M. Al-Khatib, Anne S. Hellkamp, Adrian F. Hernandez, Gregg C. Fonarow, Kevin L. Thomas, Hussein R. Al-Khalidi, Paul A. Heidenreich, Stephen Hammill, Clyde Yancy, Eric D. Peterson
Journal: Circulation (2012)

Prior studies have demonstrated low use of implantable cardioverter defibrillators (ICDs) as primary prevention, particularly among women and blacks. The degree to which the overall use of ICD therapy and disparities in use have changed is unclear.
Recent developments in lymphocyte activation: linking kinases to downstream signaling events
Authors: James L. Clements, Gary A. Koretzky
Journal: Journal of Clinical Investigation (1999)

The role of protein-protein interaction domains in signal transduction has been a topic of intensive study for the last ten years.Many of these studies have focused on the role of protein-protein interactions in signaling downstream of receptor and nonreceptor tyrosine kinases.However, recent evidence has pointed to the extensive role of proteinprotein interaction domains in the localization and scaffolding of signaling molecules.In the continuation of this Perspective series from the March 1999, no.6, issue, two articles discuss the role of protein-protein interactions in signaling downstream of tyrosine kinases.Clements and Koretzky highlight new insights into signaling by lymphocytes, while Virkamäki, Ueki, and Kahn examine the role of protein-protein interactions in insulin signaling and insulin resistance.In the previous issue, Schillace and Scott provided an overview of targeting in signal transduction by protein kinases and phosphatases, while Fanning and Anderson explored PDZ domains, important for receptor targeting and clustering in a variety of cell systems. SERIES on protein-protein interaction domains in signal transduction
A glass of water and somewhere to whinge
Authors: R. Smith
Journal: BMJ (1996)

Almost 10 years ago the United States Office of Technology Assessment predicted that the time would come when authors of scientific papers would communicate directly with readers through electronic networks. Scientific journals would not be needed. Ten years ago few people had heard of the Internet and even fewer people were connected to it. Now many millions of people are connected, and the number increases rapidly everyday. The network is in place for the academy's prediction to come true.

Why would authors want to go directly to readers? Speed. To avoid interference from editors and other …
Richter's Syndrome Findings on Ga-67 and Bone Marrow Imaging
Authors: MORDECHAI LORBERBOYM, CHUN K. KIM, NATHANIEL WISCH
Journal: Clinical Nuclear Medicine (1996)

A 65-year-old man with a history of chronic lymphocytic leukemia had enlarging lymph nodes in the inguinal region that did not respond to the usual chemotherapy. A biopsy revealed a large cell immunoblastic lymphoma(type B). A Ga-67 scan at that time revealed multiple sites of uptake in soft tissues and bones. A bone marrow scan clarified the findings in the long bones.
Abstract 3422: Synthetic lethal siRNA screening reveals novel modifiers of insulin-like growth factor-1 receptor (IGF1R) inhibitor activity in childhood sarcomas
Authors: Jenny Potratz, Darren Saunders, Daniel Wai, C Patrick Reynolds, Jonathan D. Buckley, Robert J. Arceci, Gregory H. Reaman, Timothy J. Triche, Heribert Jürgens, Michael Pollak, Poul HB Sorensen
Journal: Cancer Research (2010)

Abstract The insulin-like growth factor-1 receptor (IGF1R) is emerging as a therapeutic target in many cancers including Ewing family tumors and other childhood sarcomas, where IGF1R blocking antibodies show promising anti-tumor activity in some but not all patients. A key question remains as to what underlies IGF1R inhibitor sensitivity versus resistance. IGF1R mutations have to date not been found in these tumors. Instead, we hypothesize that compensatory signaling circuits by-passing targeted IGF1R inhibition are involved. We performed synthetic lethal siRNA screens in Ewing family tumor cell lines to study the IGF1R signaling axis and related protein tyrosine kinase networks in the presence and absence of sub-lethal doses of an IGF1R kinase inhibitor, with the goal of identifying siRNAs that restored full inhibitor activity. This strategy revealed (1) that Ewing sarcoma and rhabdomyosarcoma cells are exquisitely sensitive to loss of distal IGF1R signaling components such as the ribosomal protein S6 (RPS6); (2) IGF1R inhibitors fail to block RPS6 activation in resistant cell lines; and (3) that siRNA knock-down of certain protein tyrosine kinases such as the MET family receptor MST1R restores inhibitor efficacy, even in highly drug resistant cell lines. Moreover, we confirmed MST1R expression in childhood sarcomas and found that loss of MST1R blocks downstream RPS6 activation when combined with IGF1R inhibition in vitro. Taken together, we present an approach in principle applicable to any promising drug of interest. We demonstrate that key signaling effectors of the IGF1R axis in childhood sarcomas represent distal pathway proteins such as RPS6, and we identify the MST1R receptor tyrosine kinase as a potential therapeutic target whose knock-down markedly enhances sensitivity to IGF1R inhibition in high-risk sarcoma cell types, including resistant lines. These data underscore the importance of fully understanding protein tyrosine kinase networks for successful implementation of kinase inhibitor strategies. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3422.
Adverse Drug Reactions and Associated Deaths
Authors: William R. Barclay
Journal: JAMA (1976)

Two articles that deal with adverse drug reactions (ADR), one by Nelson S. Irey in this issue ofThe Journal(p 575) and one in the<i>Archives of Internal Medicine</i>,<sup>1</sup>merit special attention because they present data that contradict conclusions arrived at by a Senate subcommittee in 1974—conclusions that received wide attention in the public press. The problem of ADR is well known to most physicians and is the subject of many published papers that include case reports, statistical studies, reviews, editorials, and philosophical dissertations. In spite of this large extant literature, it is important to add information from carefully performed studies such as the two referred to here. The paper by Irey from the Armed Forces Institute of Pathology, Registry of Tissue Reactions to Drugs, classifies 827 autopsied cases of adverse drug reactions and finds that only 25 or 3.0% were due to therapeutic errors and should therefore
SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation
Authors: Ichiko Kinjyo, Toshikatsu Hanada, Kyoko Inagaki-Ohara, Hiroyuki Mori, Daisuke Aki, Masanobu Ohishi, Hiroki Yoshida, Masato Kubo, Akihiko Yoshimura
Journal: Immunity (2002)
211. Development of Helper-Dependent Adenovirus (HDAd) Vectors for Gene Therapy in the Mouse Model for Glycogen Storage Disease Type Ia (GSD-Ia)
Authors: Dwight D. Koeberl, Lopamudra Banerjee, Baodong Sun, Andrew Bird, Y.T. Chen, Kazuhiro Hiro, Lawrence Chan
Journal: Molecular Therapy (2006)

Objective: The deficiency of glucose-6-phosphatase (G6Pase) underlies glycogen storage disease type Ia (GSD-Ia, also known as von Gierke disease; MIM 232200), an autosomal recessive disorder of metabolism associated with life-threatening hypoglycemia and growth retardation. Regulation of G6Pase at the level of transcription occurs in response to glucose and insulin levels. We investigated the hypothesis that G6Pase expression with an HDAd vector containing a glucose-response promoter would correct hypoglycemia and prolong survival in GSD-I mice. Methods: An HDAd vector containing the PEPCK promoter driving G6Pase expression was administered intravenously (5 × 1012 vector particles/kg) to 2 week-old affected G6Pase-KO mice. Results: Survival was prolonged following HDAd vector administration to a median of 7 months, in contrast to untreated affected mice that did not survive past 3 weeks of age. Early loss of affected mice was related to the kinetics of HDAd vector-mediated transgene expression, because G6Pase levels increased >10-fold between 3 days and 28 weeks post-administration (p<0.05). Growth was normalized following HDAd vector administration, whereas untreated, affected mice initially weighed approximately 50% as much as unaffected littermates. Mice that received the HDAd vector encoding G6Pase had normal blood glucose (164 +/- 29 mg/dl), in contrast to non-fasting, untreated G6Pase-KO mice which were hypoglycemic (31 +/- 19 mg/dL) (p < 0.005). Hypercholesterolemia was resolved completely following HDAd vector administration. Glucose supplementation was discontinued at 1 month of age for treated mice, even though untreated mice could only be sustained through twice daily glucose injections. Glycogen content was decreased in the liver following HDAd vector administration, consistent with liver-targeted transduction following intravenous injection of the HDAd vector. Conclusions: The efficacy of G6Pase expression with the HDAd vector in GSD-Ia mice was established by prolonged survival, correction of fasting hypoglycemia, correction of growth retardation, and reduction of liver glycogen content. The efficacy of HDAd vector-mediated G6Pase expression initiated during mid-infancy is highly relevant to GSD-Ia patients, for whom the diagnosis is typically established several months following birth.
The Possibility That Multiple Mucocutaneous (Palisaded Encapsulated and Nonencapsulated) Neuromas May Be a Distinct Entity
Authors: Noriyuki Misago, Keiichiro Joh, Hidenobu Soejima, Yutaka Narisawa
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
THE RELATION BETWEEN THE INGESTION OF COLOSTRUM OR BLOOD SERUM AND THE APPEARANCE OF GLOBULIN AND ALBUMIN IN THE BLOOD AND URINE OF THE NEW-BORN CALF
Authors: Paul E. Howe
Journal: The Journal of Experimental Medicine (1924)

The coincidence of the appearance of euglobulin and pseudo-globulin I in the blood and urine of the new-born calf following the ingestion of colostrum and the absence of these proteins when milk is fed support the inference that the proteinuria of the new-born calf is due to the ingestion of colostrum. In this passage the proteins are in part unaltered. The absorption and excretion of the proteins of blood serum have been observed. The high protein content of the feces of young calves-during the first few days-is to be ascribed, in part at least, to ingested colostrum.
Pneumatic dilatation in achalasia.
Authors: I W Fellows, A L Ogilvie, M Atkinson
Journal: Gut (1983)

To assess the value of pneumatic dilatation of the cardia, 63 patients with achalasia have undergone a total of 107 Rider-Moeller dilatations over the last six years. There was a marked improvement in swallowing immediately after dilatation in all but two patients, there were no deaths attributable to the procedure and serious complications were rare (1.6% of patients). The first 50 cases have been followed from nine to 73 months after their initial dilatation (mean follow-up 29.7 months). Twenty nine patients (58%) have not required a further dilatation, 19 patients (38%) required between one and three further dilatations and two patients (4%) required four more dilatations. Continuing need for further dilatation was significantly greater in those patients aged under 45 years than in those aged 45 or more at the time of their initial dilatation (p less than 0.001). Cardiomyotomy was necessary in five patients (10%), because of poor response to pneumatic dilatation; all five cases were under 45 years old at their initial dilatation. Pneumatic dilatation is a safe and effective treatment for achalasia, particularly in the older patient, and in our opinion should be the initial treatment for all patients with achalasia, reserving surgical cardiomyotomy for those who do not respond to several dilatations.
The basement membrane zone in lichen sclerosus: an immunohistochemical study
Authors: P. MARREN, D. DEAN, M. CHARNOCK, F. WOJNAROWSKA
Journal: British Journal of Dermatology (1997)

The alteration in expression of basement membrane zone (BMZ) components in lichen sclerosus was investigated by immunohistochemical staining of skin biopsies from seven patients with histologically confirmed disease compared with controls. Monoclonal antibodies and polyclonal sera directed against proteins of the hemidesmosomes, anchoring fibrils, lamina lucida, lamina densa and BMZ collagens were used. Characteristic histological appearances at the dermo-epidermal junction were reflected in widespread alterations in antigen expression in the epidermal basement membrane and the papillary dermis. Expression of the proteins which constitute the structural scaffold (collagen IV and VII) were increased in lichen sclerosus. Expression of hemidesmosomal proteins which mediate adhesion and cell to matrix interaction (alpha 6 beta 4 and bullous pemphigoid antigen) and expression of anchoring filament components were markedly reduced, suggesting that the epidermal cells are exposed to selective damage.
Helicobacter pylori: comparison of DNA fingerprints provides evidence for intrafamilial infection.
Authors: K B Bamford, J Bickley, J S Collins, B T Johnston, S Potts, V Boston, R J Owen, J M Sloan
Journal: Gut (1993)

Although a high prevalence of antibodies to Helicobacter pylori has been documented within families, culture and DNA typing of strains from infected children and their parents has not been evaluated. This study aimed to analyse H pylori infection within family groups. Endoscopy, gastric biopsy, and H pylori culture were performed on all eight parents of four children who presented with dyspepsia and who had a positive H pylori culture. All biopsy specimens were cultured on Columbia based blood agar under microaerophilic conditions for four days. The DNA from each strain was extracted and electrophoretic patterns were compared after digestion with restriction endonucleases Hae III or Hind III. Ribotyping using a biotinylated cDNA probe prepared from 16S and 23S rRNA of H pylori NCTC 11638 was also used. Seven of the parents were positive for H pylori on urease testing, histology, and on culture. DNA typing showed the same or a similar strain to be present in at least two family members in three of the four family groups. In family 1, the mother, father, and child all had an identical strain; in family 2, father and son had a similar related strain; father and mother had the same strain in family 3; and all strains were unique in family 4. These data provide evidence for either intrafamilial cross infection or a common source of infection within family groups.
29 BUDESONIDE 3 MG TID IN THE TREATMENT OF AUTOIMMUNE HEPATITIS (AIH) IN ADOLESCENTS, A SUBGROUP ANALYSIS OF THE EUROPEAN AIH-BUC-STUDY
Authors: M. Woynarowski, A. Nemeth, Y. Baruch, S. Koletzko, M. Melter, B. Rodeck, C. Strassburg, M. Proels, M.P. Manns
Journal: Journal of Hepatology (2011)
African Americans and HIV/AIDS: Understanding and Addressing the Epidemic
Authors: Eve D. Mokotoff
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal