tbuckley/cabot-search huggingface dataset:
Authors' reply to Whitehouse and Fabre
Authors: L. J. O'Doherty, A. Taft, K. Hegarty, J. Ramsay, L. L. Davidson, G. Feder
Journal: BMJ (2014)

Unlike Whitehouse, we do not think that our findings will “discourage health professionals from identifying and signposting” as long as they receive regular and sustained training and resources on identification and appropriate responses.1 2 We are definitely not saying that clinicians should sit back and wait for disclosures of intimate partner violence.

We agree with Fabre that case finding …
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
Authors: Till Strowig, Cagan Gurer, Alexander Ploss, Yi-Fang Liu, Frida Arrey, Junji Sashihara, Gloria Koo, Charles M. Rice, James W. Young, Amy Chadburn, Jeffrey I. Cohen, Christian Münz
Journal: The Journal of Experimental Medicine (2009)

Many pathogens that cause human disease infect only humans. To identify the mechanisms of immune protection against these pathogens and also to evaluate promising vaccine candidates, a small animal model would be desirable. We demonstrate that primary T cell responses in mice with reconstituted human immune system components control infection with the oncogenic and persistent Epstein-Barr virus (EBV). These cytotoxic and interferon-γ–producing T cell responses were human leukocyte antigen (HLA) restricted and specific for EBV-derived peptides. In HLA-A2 transgenic animals and similar to human EBV carriers, T cell responses against lytic EBV antigens dominated over recognition of latent EBV antigens. T cell depletion resulted in elevated viral loads and emergence of EBV-associated lymphoproliferative disease. Both loss of CD4+ and CD8+ T cells abolished immune control. Therefore, this mouse model recapitulates features of symptomatic primary EBV infection and generates T cell–mediated immune control that resists oncogenic transformation.
Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats
Authors: Yutaka Nakaya, Noriko Ishimura, Eiko Takishita, Akira Takahashi
Journal: Metabolism (2002)
Effect of short-term hormone replacement in the treatment of obstructive sleep apnoea in postmenopausal women.
Authors: P A Cistulli, D J Barnes, R R Grunstein, C E Sullivan
Journal: Thorax (1994)

BACKGROUND--Women appear to be increasingly susceptible to snoring and sleep disordered breathing after the menopause. This observation, coupled with the considerable sex difference in sleep apnoea, may be explained on the basis of a protective effect of female hormones. This study was carried out to determine whether hormone replacement therapy has a role in the management of obstructive sleep apnoea in postmenopausal women. METHODS--The effect of short-term (mean (SE) 50 (3) days) hormone replacement therapy with either oestrogen alone or in combination with progesterone on sleep disordered breathing was investigated in 15 postmenopausal women with moderate obstructive sleep apnoea. The effect of treatment on the ventilatory response to hypoxia and hypercapnia was assessed in 10 patients. RESULTS--There was no reduction in the clinical severity of obstructive sleep apnoea after hormone treatment despite an increase in the serum oestrogen level from 172 (23) to 322 (33) pmol/l. There was a small but clinically insignificant reduction in the apnoea/hypopnoea index during REM sleep from 58 (6) to 47 (7). There was no difference in response between the oestrogen only group and the oestrogen plus progesterone group. Hypercapnic ventilatory responsiveness did not change with hormone treatment, but an change with hormone treatment, but an increase in hypoxic ventilatory responsiveness was observed. CONCLUSIONS--These data indicate that short-term hormone replacement is unlikely to have an effective role in the clinical management of postmenopausal women with obstructive sleep apnoea. The observed reduction in the apnoea/hypopnoea index during REM sleep, however, suggests that longer term treatment, or the use of higher doses, may have an effect.
Metabolic Syndrome Does Not Detect Metabolic Risk in African Men Living in the U.S.
Authors: Ugochi J. Ukegbu, Darleen C. Castillo, Michael G. Knight, Madia Ricks, Bernard V. Miller, Barbara M. Onumah, Anne E. Sumner
Journal: Diabetes Care (2011)

Metabolic risk and metabolic syndrome (MetSyn) prevalence were compared in Africans who immigrated to the U.S. and African Americans. If MetSyn were an effective predictor of cardiometabolic risk, then the group with a worse metabolic risk profile would have a higher rate of MetSyn.Cross-sectional analyses were performed on 95 men (39 Africans, 56 African Americans, age 38 ± 6 years [mean ± SD]). Glucose tolerance was determined by oral glucose tolerance test, visceral adipose tissue (VAT) was determined by computerized tomography, and MetSyn was determined by the presence of three of five factors: central obesity, hypertriglyceridemia, low levels of HDL cholesterol, hypertension, and fasting hyperglycemia.MetSyn prevalence was similar in Africans and African Americans (10 vs. 13%, P = 0.74), but hypertension, glycemia (fasting and 2-h glucose), and VAT were higher in Africans.African immigrants have a worse metabolic profile than African Americans but a similar prevalence of MetSyn. Therefore, MetSyn may underpredict metabolic risk in Africans.
Eosinophil cationic protein in inflammatory synovial effusions as evidence of eosinophil involvement.
Authors: R Hallgren, A Bjelle, P Venge
Journal: Annals of the Rheumatic Diseases (1984)

Eosinophils are seldom noted in inflammatory synovial fluids but are reported to infiltrate the synovial tissue in inflammatory arthritides. To elucidate a possible role for eosinophils in inflammatory joint reactions the concentrations of eosinophil cationic protein (ECP)--a specific granule protein from eosinophils--were measured by radioimmunoassay in 90 synovial fluids from patients with various inflammatory arthritides (rheumatoid arthritis, reactive and crystal arthritides, Reiter9s disease and psoriatic arthropathy). In the same specimens lactoferrin was measured as an indicator of neutrophil-involved inflammation. In comparison with the normal circulating levels of ECP and lactoferrin the measured synovial fluid concentrations of both proteins were considerably raised in all patient groups with inflammatory joint diseases in contrast to patients with non-inflammatory arthritides. There was a striking positive correlation between the ECP and lactoferrin synovial fluid concentrations. These data indicate that eosinophil activation is prominent in inflammatory joint reactions and is linked to the activation of neutrophils. The regulation of degranulation or secretion by eosinophils is unknown. Our in-vitro studies showed that peripheral blood isolated neutrophils as well as eosinophils degranulated when exposed to IgG complexes. However, eosinophil degranulation was modest compared with neutrophil degranulation. These data suggest that neutrophil phagocytosis of, for example, immune complexes may be one major mechanism in neutrophil degranulation but that other factors determine the appearance of eosinophil products in inflammatory synovial effusions. The possible modulatory or harmful role of eosinophils in inflammatory joint disease can at present only be speculated on.
Is microsomal triglyceride transfer protein the missing link in abetalipoproteinemia? Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M, Schmitz J, Gay G, Rader DJ, Gregg RE. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science 1992; 258: 999–1001
Authors: R Hamilton
Journal: Hepatology (1993)
Offspring from artificial insemination demand fathers' details
Authors: C. Dyer
Journal: BMJ (2000)

A British brother and sister who were conceived by artificial insemination with donor semen are to launch a test case at the High Court in London to try to find out details of their biological fathers.

The civil liberties group Liberty is mounting the challenge to the ban on donor identification in the Human Fertilisation and Embryology Act on behalf of Adam Rose, aged 34, his sister Joanna, aged 28, and several other adults born as a result of artificial insemination.

The case is expected to be one of the first to be launched after …
Cutaneous Richter syndrome: a better place to transform?
Authors: J. Kluk, M. Moonim, A. Duran, J. Costa Rosa, J. Cabeçadas, R. Alvarez, M. Cravo, S. Whittaker, A. Robson
Journal: British Journal of Dermatology (2014)

Journal Article Cutaneous Richter syndrome: a better place to transform? Get access J. Kluk, J. Kluk Skin Tumour Unit 2nd Floor, Block C, South Wing St. John's Institute of Dermatology St Thomas' Hospital Westminster Bridge Road London SE1 7EH U.K Correspondence Justine Kluk. E‐mail: justine.kluk@gstt.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar M. Moonim, M. Moonim Department of Histopathology 2nd Floor, North Wing St Thomas' Hospital Westminster Bridge Road London SE1 7EH U.K Search for other works by this author on: Oxford Academic Google Scholar A. Duran, A. Duran Department of Haematology Queen Elizabeth Hospital Stadium Road London SE18 4QH U.K Search for other works by this author on: Oxford Academic Google Scholar J. Costa Rosa, J. Costa Rosa Serviço de Anatomia Patológica Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Professor Lima Basto 1099‐023 Lisboa Portugal Search for other works by this author on: Oxford Academic Google Scholar J. Cabeçadas, J. Cabeçadas Serviço de Anatomia Patológica Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Professor Lima Basto 1099‐023 Lisboa Portugal Search for other works by this author on: Oxford Academic Google Scholar R. Alvarez, R. Alvarez Departmento de Hematologia Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Professor Lima Basto 1099‐023 Lisboa Portugal Search for other works by this author on: Oxford Academic Google Scholar M. Cravo, M. Cravo Serviço de Dermatologia Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Professor Lima Basto 1099‐023 Lisboa Portugal Search for other works by this author on: Oxford Academic Google Scholar S. Whittaker, S. Whittaker Skin Tumour Unit 2nd Floor, Block C, South Wing St. John's Institute of Dermatology St Thomas' Hospital Westminster Bridge Road London SE1 7EH U.K Search for other works by this author on: Oxford Academic Google Scholar A. Robson A. Robson Dermatopathology Department St John's Institute of Dermatology 2nd floor, South Wing Staircase C St Thomas' Hospital Westminster Bridge Road London SE1 7EH U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 2, 1 February 2015, Pages 513–521, https://doi.org/10.1111/bjd.13193 Published: 01 February 2015
Liver sinusoidal endothelial cells and liver regeneration
Authors: Laurie D. DeLeve
Journal: Journal of Clinical Investigation (2013)

Liver sinusoidal endothelial cells (LSECs) have long been noted to contribute to liver regeneration after liver injury. In normal liver, the major cellular source of HGF is the hepatic stellate cell, but after liver injury, HGF expression has been thought to increase markedly in proliferating LSECs. However, emerging data suggest that even after injury, LSEC expression of HGF does not increase greatly. In contrast, bone marrow progenitor cells of LSECs (BM SPCs), which are rich in HGF, are recruited to the liver after injury. This Review examines liver regeneration from the perspective that BM SPCs that have been recruited to the liver, rather than mature LSECs, drive liver regeneration.
Occupational alopecia or alopecia areata?
Authors: Antonella Tosti, Bianca Maria Piraccini, Wilma F. Bergfeld, Francisco Camacho, Rodney P.R. Dawber, Rudolf Happle, Elise A. Olsen, Vera H. Price, Alfredo Rebora, Jerry Shapiro, Rod Sinclair, Dominique VanNeste, David A. Whiting
Journal: Journal of the American Academy of Dermatology (2002)
Intranasal Oxytocin in Obstetrics
Authors: Charles H. Hendricks
Journal: JAMA (1961)

Brief exposures to synthetic oxytocin, applied intranasally as a spray, were used in 74 cases of induced labor, 138 cases for enhancement of labor, 39 cases for testing sensitivity to oxytocin, and 15 cases for enhancement of prelabor. The purpose was to obtain a mild stimulation of uterine activity, usually for 15 to 20 minutes. The method of application is remarkably simple, and the authors recommend it as having a wide degree of safety in determining the degree of labor readiness of a patient at term, in inducing labor (in combination with amniotomy), and especially in combating mild degrees of secondary inertia which appear during labor.
The Medical Realities of Civil Defense
Authors: Leonard B. Greentree
Journal: New England Journal of Medicine (1971)

Abstract The lack of meaningful stockpiles of critical and strategic medical supplies at the local community level seriously compromises effective medical care of the millions of civilian casualties to be expected in the event of a nuclear attack on the United States. Although critical medical supplies as well as packaged disaster hospitals are maintained in 12 supply depots in the country, the efficient use of these supplies appears hampered by inadequate plans for their mobilization, distribution and application during emergency conditions. Equally wanting are supplies and equipment to protect civilians against the possible effects of chemical and biologic weapons. In contrast, the Soviet Union is believed to have a complete program of civil defense against both types of warfare.
A METHOD FOR THE RAPID PREPARATION OF ANTIMENINGITIS SERUM
Authors: Harold L. Amoss, Martha Wollstein
Journal: The Journal of Experimental Medicine (1916)

Potent antimeningitis serum can be safely produced in the horse by the method of three successive intravenous inoculations of living meningococci and parameningococci repeated at stated intervals. Sudden and alarming symptoms and sudden death are avoided by employing first a desensitizing injection and then by adjusting the doses according to the febrile reaction and by making the highly diluted injections slowly. Horses undergoing this process of immunization remain in good condition and may even gain in weight. Specific immune bodies appear in the serum early and rise rapidly. By inoculating alternately several strains of living meningococci and parameningococci, and the autolyzed products of each, a polyvalent serum of high titer can be produced in 8 to 12 weeks instead of in the 10 months required by the subcutaneous method. The serum produced by this rapid method has been employed therapeutically in America, England, France, and some other countries. It is highly desirable to isolate meningococci from many sources and test the strains against the polyvalent serum. Strains which are not agglutinated in high dilution in such a serum should be included subsequently in the lot of strains used for immunization.
The Significance of Immunoassayable Insulin in Urine
Authors: Arthur H. Rubenstein
Journal: JAMA (1969)

Although a great deal of information is available regarding levels of circulating plasma insulin, not much is known of its extravascular and intracellular concentrations. A number of recent studies have measured insulin in bile, cerebrospinal fluid, and lymph, while this report is concerned with the usefulness and significance of urinary insulin in health and some disease states. There are certain advantages in measuring insulin in urine. It reflects average serum levels over an extended period of time and is useful in situations in which repeated blood sampling is impractical, such as the newborn. Measurement of urine insulin is feasible in insulin-requiring diabetic patients for their serum antibodies do not usually pass the glomerulus. Finally, urine or lymphatic insulin may be a more valid reflection of the tissue concentration than the intravascular levels. <h3>Methods</h3><h3>Assay Technique.—</h3> Before sensitive immunologic methods were available, complicated extraction and purification techniques were necessary for the
Neck Radiation and Hyperparathyroidism
Authors: DENNIS A. TAYLOR
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 December 1978Neck Radiation and HyperparathyroidismDENNIS A. TAYLOR, M.D., FRED J. PALMER, M.D., THOMAS M. SAWYERS, M.D.DENNIS A. TAYLOR, M.D.Search for more papers by this author, FRED J. PALMER, M.D.Search for more papers by this author, THOMAS M. SAWYERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-6-1012_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have read with interest the recent reports of apparent radiation-induced hyperparathyroidism (1, 2). The reported fraction of hyperparathyroidism associated with radiation therapy to the neck is 14% to 30% (3, 4). Parathyroid lesions have included adenomas and hyperplasia.We have reviewed 66 cases of hyperparathyroidism seen by us over the last 4 years. Of the 66 patients, 44 (67%) were women (mean age, 55 years; range, 28 to 78 years) and 22 (33%) were men (mean age, 53 years; range, 36 to 65 years). Six patients (9%) had received antecedent radiation therapy to the neck, one...References1. SCHACHNERHALL SA: Parathyroid adenoma and previous head-and-neck irradiation. Ann Intern Med 88:804, 1978 LinkGoogle Scholar2. CHRISTENSSON T: Hyperparathyroidism and radiation therapy. Ann Intern Med 89:216-217, 1978 LinkGoogle Scholar3. TISSELLCARLSSONLINDBERGRAGNHULT LSSI: Autonomous hyperparathyroidism—a possible late complication of neck radiotherapy. Acta Chir Scand 142:367-373, 1976 MedlineGoogle Scholar4. PALOYANLAWRENCEPRINZPICKLEMANBRAITHWAITEBROOKS EARJSM: Radiation-associated hyperparathyroidism (letter). Lancet 1:949, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kaiser Foundation Hospital Fontana, CA 92335 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHyperparathyroidism after radioactive iodine therapyHyperparathyroidism following irradiation of benign diseases of the head and neckAssociation between primary hyperparathyroidism and previous irradiation 1 December 1978Volume 89, Issue 6Page: 1012-1013KeywordsAdenomasHyperparathyroidismLesionsParathyroidRadiation therapy Issue Published: 1 December 1978 PDF DownloadLoading ...
Abstract LB-100: Discovery of HM61713 as an orally available and mutant EGFR selective inhibitor
Authors: Kwang-Ok Lee, Mi Young Cha, Mira Kim, Ji Yeon Song, Jae-Ho Lee, Young Hoon Kim, Young-Mi Lee, Kwee Hyun Suh, Jeewoong Son
Journal: Cancer Research (2014)

Abstract Introduction: Activating mutations of EGFR are well known as oncogenic driver mutations in lung adenocarcinoma. Currently, EGFR TKIs including Gefitinib and Erlotinib are used as the first line therapy in NSCLC patients harboring EGFR activating mutations. However, drug resistance caused by T790M mutation limits the efficacy of these 1st generation EGFR TKIs. Currently, some of the next generation EGFR TKIs are under investigation for the treatment of lung cancer patients having T790M mutation. In our current presentation, to obtain HM61713, an EGFR mutant selective inhibitor, as a clinical candidate and the evaluation of HM61713 for mutant EGFR cancer model will be introduced. Method: Novel analogues were designed and synthesized to find active compounds for the T790M mutation as well as EGFR activating mutations with good selectivity over wild- type EGFR. Finally, HM61713 was selected as a clinical candidate through multi-optimization processes including both in vitro and in vivo pharmacologcal studies. Results: HM61713 was designed as an irreversible kinase inhibitor having a Michael acceptor, which covalently binds to a cysteine residue near the kinase domain of mutant the EGFR. In a cell wash out test, HM61713 inhibited phospho-EGFR for a long duration with a half-life of over 24 hours. From in vitro study, HM61713 showed potent activities for H1975 (L858-T790M) and HCC827 (exon 19 del.) with GI50 values of 9.2 nM and 10 nM, respectively. Instead, it showed low potency for H358 (wild type EGFR NSCLC) with GI50 of 2,225 nM. In xenograft studies using H1975 and HCC827, HM61713 resulted in good efficacy without showing any side effects. Conclusion: HM61713 showed excellent in vitro and in vivo activities for H1975 harboring L858R-T790M mutation as well as HCC827 having exon 19 deletion mutation with selectivity over wild-type EGFR. Currently, HM61713 is undergoing phase I study (NCT01588145) for NSCLC patients after the failure of 1st generation EGFR TKIs in Korea. Citation Format: Kwang-Ok Lee, Mi Young Cha, Mira Kim, Ji Yeon Song, Jae-Ho Lee, Young Hoon Kim, Young-Mi Lee, Kwee Hyun Suh, Jeewoong Son. Discovery of HM61713 as an orally available and mutant EGFR selective inhibitor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-100. doi:10.1158/1538-7445.AM2014-LB-100
BMA calls on G8 governments to address “brain drain”
Authors: Susan Mayor
Journal: BMJ (2005)

The BMA and the Royal College of Nursing are calling on the leaders of the eight most industrialised nations to take action to reduce the exodus of healthcare workers from developing countries, as part of what they consider an essential step in improving the health of people living there.

The chairman of the BMA, James Johnson, and general secretary of the royal college, Beverly Malone, warned, in letters sent last week to Prime Minister Tony Blair and the chancellor of the exchequer, Gordon Brown, that the migration of healthcare workers from …
Thyroid Cancers with Benign-Looking Sonographic Features Have Different Lymph Node Metastatic Risk and Histologic Subtypes According to Nodule Size
Authors: Dong Yeob Shin, Young Ki Lee, Kwang Joon Kim, Kyeong Hye Park, Sena Hwang, Se Hee Park, Eun-Kyung Kim, Hyeong Ju Kwon, Eun Jig Lee
Journal: Endocrine Pathology (2014)
Cardiac myosin light and heavy chain isotypes in tetralogy of Fallot
Authors: L. M AUCKLAND, S. J LAMBERT, P. CUMMINS
Journal: Cardiovascular Research (1986)

Journal Article Cardiac myosin light and heavy chain isotypes in tetralogy of Fallot Get access LUCY M AUCKLAND, LUCY M AUCKLAND From the Molecular Cardiology Unit, Department of Cardiovascular Medicine. University of Birmingham, Birmingham Search for other works by this author on: Oxford Academic PubMed Google Scholar SIMON J LAMBERT, SIMON J LAMBERT From the Molecular Cardiology Unit, Department of Cardiovascular Medicine. University of Birmingham, Birmingham Search for other works by this author on: Oxford Academic PubMed Google Scholar PETER CUMMINS PETER CUMMINS From the Molecular Cardiology Unit, Department of Cardiovascular Medicine. University of Birmingham, Birmingham Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 20, Issue 11, November 1986, Pages 828–836, https://doi.org/10.1093/cvr/20.11.828 Published: 01 November 1986