tbuckley/cabot-search huggingface dataset:
Structure of Genetic and Environmental Risk Factors for Symptoms of<i>DSM-IV</i>Borderline Personality Disorder
Authors: Ted Reichborn-Kjennerud, Eivind Ystrom, Michael C. Neale, Steven H. Aggen, Suzanne E. Mazzeo, Gun Peggy Knudsen, Kristian Tambs, Nikolai O. Czajkowski, Kenneth S. Kendler
Journal: JAMA Psychiatry (2013)

Previous studies have indicated that the psychopathological dimensions of borderline personality disorder (BPD) are influenced by a unitary liability factor. However, to our knowledge, the underlying etiological nature of the individual criteria for BPD as defined by the DSM-IV has not been explored.To determine the structure of genetic and environmental risk factors for the symptoms of BPD.Multivariate twin study with BPD criteria assessed by personal interview within a general community setting. Participants included 2794 young adults from the Norwegian Institute of Public Health Twin Panel.The 9 criteria for BPD assessed by the Structured Interview for DSM-IV Personality.A common pathway model dominated by 1 highly heritable (55%) general BPD factor that strongly influenced all 9 BPD criteria (standardized path coefficients, 0.53-0.79) fit the data best. The model also included 2 additional common liability factors, mainly influencing criteria reflecting the affective and interpersonal dimensions. Both of these were mostly influenced by environmental liability factors (heritability, 29.3% and 2.2%). With 1 exception (criterion 2, unstable and intense relationships), the specific criteria were strongly influenced by environmental factors. Five of the 9 criterion-specific genetic effects were either 0 or negligible.These results indicate that most of the genetic effects on the individual BPD criteria derive from 1 highly heritable general BPD factor, whereas the environmental influences were mostly criterion specific.
"Swallowed" Endotracheal Tube
Authors: R. Binning
Journal: BMJ (1967)

the Luntz series are in fact cases listed in Wright's account under the headings " Ocular Hypertension " and " Possible Early Glau- coma," with a combined prevalence of 3 %.The Luntz series clearly excluded any cases of true glaucoma, and indeed all patients with any history of previous eye disease.As the authors give no criteria for their diagnosis of glaucoma, it is impossible to say to what ex- tent their findings can be compared with either survey.They certainly cannot be compared with both.The literature of glaucoma abounds in such comparisons of in- compatible data.It is depressing also to note that the defi- ciencies of a single measurement of ocular pressure as a means of detecting glaucoma still do not appear to be fully appreciated.This aspect of the problem is discussed in the same symposium and more fully in the account of the Royal Society of Medicine's 1966 Annual Symposium on Presymptomatic Screening.2It would be interesting to know if the authors have read these papers and are aware of the objections to tonometric screen- ing.-I am, etc.,
Points: Impact of cuts in acute beds on services for patients
Authors: A. Clark
Journal: BMJ (1987)

Professor D C Carter (7 March, p 593) com- ments on the treatment of hepatic metastases by surgical debulking, but the value of hepatic arterial embolisation is not mentioned.'2In our experience, when vascular endocrine metastases are detected in the liver, providing that the intrahepatic portal veins are patent, hepatic arterial embolisation can provide
Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment
Authors: M.P. Morelli, M.J. Overman, A. Dasari, S.M.A. Kazmi, T. Mazard, E. Vilar, V.K. Morris, M.S. Lee, D. Herron, C. Eng, J. Morris, B.K. Kee, F. Janku, F.L. Deaton, C. Garrett, D. Maru, F. Diehl, P. Angenendt, S. Kopetz
Journal: Annals of Oncology (2015)
Osteopetrosis: Nuclear Medicine Pathophysiologic Correlation
Authors: CHRISTOPHER J. PALESTRO, DEBORA FINEMAN, ROBERT W. SOLOMON, CHUN K. KIM, STANLEY J. GOLDSMITH
Journal: Clinical Nuclear Medicine (1989)

The authors present the case of a 28-year-old woman with osteopetrosis who underwent multiple nuclear medicine procedures, making it possible for the nuclear medicine pathophysiologic correlales in this unusual disease to be studied.
Silicone Rubber Suction Tubing
Authors: Richard R. Jackson
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Most operating room suction tubing is either natural rubber (amber, gum, latex) or a natural-synthetic combination (as red rubber). These products soften, darken, and become gummy after 50 to 75 steam autoclavings and must be discarded. Disposable plastic tubing is very acceptable; however, in our opinion is too expensive for routine use. Medical-grade silicone tubing is ideal, but its price is prohibitive. It can be reused indefinitely, since it is unaffected by the heat of steam autoclaving. Silicone tubing is used in industry. The commercial grade contains fillers so the price of the product is markedly reduced. Our seven-room operating suite is equipped with commercial-grade silicone tubing one-quarter inch inside diameter by one-eighth inch wall thickness. It is unaffected by autoclaving, having a working temperature range of —60 F to +500 F. It does not stick to suction tubes after autoclaving, as do natural rubber products. Some
Abstract 3194: Epidermal growth factor receptor variant type III induces angiopoietin like 4 expression through mitogen activated protein kinase pathway and promotes tumor angiogenesis in malignant glioma
Authors: Yasufumi Katanasaka, Fumiaki Koizumi
Journal: Cancer Research (2010)

Abstract Epidermal growth factor receptor variant III (EGFRvIII) is the most common mutation of EGFR in glioblastomas (GBMs) and is present in approximately 50% of GBMs with EGFR gene amplification and overexpression. This variant lacks the exon 2 to 7 (the extracellular ligand-binding domain) and results in a constitutively active form of the receptor. EGFRvIII has been shown to promote tumor progression in mouse models. Since it is assumed that EGFRvIII alters the tumor microenvironment, we examined the involvement of EGFRvIII in tumor angiogenesis in GBMs. For this purpose, we transfected cDNA for wild type EGFR or EGFRvIII into human glioma LN229 cells with retroviral vector (LN229-WT or LN229-vIII, respectively). The growth of LN229-vIII-tumors was significantly accelerated compared with that of LN229-WT-tumors. The microvessel density in LN229-vIII-tumors dramatically increased compared with that in LN229-WT-tumors. To study molecular mechanism of the EGFRvIII-induced angiogenesis, real time PCR analysis of angiogenesis-related molecules was performed. The analysis revealed that the expression level of angiopoietin like 4 (Angptl4) was significantly increased in LN229-vIII compared with LN229-WT in vitro. The mRNA expression of Angptl4 was remarkably increased in LN229-vIII-tumors. These results were confirmed at the protein level in vitro and in vivo. We then investigated which the signal pathway is associated with EGFRvIII-induced Angptl4 expression. MEK inhibitor U0126 remarkably inhibited Angptl4 mRNA expression in LN229-vIII, indicating that MAPK signal pathway could be an important pathway for the transcription. In summary, EGFRvIII may induce Angptl4 expression through MAPK signal pathway and strongly promote tumor angiogenesis in malignant glioma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3194.
Mycoplasma pneumoniae infections.
Authors: M C Jones
Journal: BMJ (1972)

As acute gastritis most commonly results from extrinsic irritants, it seems reasonable to postulate that the levo-dopa may have been the cause of the bleeding in this man's case.The rarity of this complication, and its occurrence in our patient without any pre- vious evidence of gastric disorder, suggests an idiosyncratic response as a possible mechanism.-I am, etc.,
The age of entitlement
Authors: Des Spence
Journal: BMJ (2005)

“ I f I fulfil this oath and do not violate it, may it be granted to me to enjoy life… if I transgress it and swear falsely, may the opposite of all this be my lot.” My thumping hangover didn't help on my graduation day. I flushed, sweated, and suppressed wave on wave of nausea. I was a cloaked polyester angel alongside 200 other gowned students in a large university hall. We stood, electricity crackling, and recited an oath before we were ushered through for graduation—I can't remember what we said or even if it was in English—but we glibly took that oath. A friend turned and said, “It's all Greek to me,” and we both laughed. Now in these faithless days the notion of an oath or even of vocation have little relevance. We are a detached and fractionated profession; conversations focus on “time limited contracts,” no payment, no work, study leave, and so on, and a sense of entitlement pervades everywhere.

> We have tarnished our profession, and it is little wonder that our …
The Smallpox Story: In Word and Pictures
Authors: Anthony J. Martel
Journal: JAMA (1989)

The conquest of an infectious disease by vaccination is a story that can reward the reader from both a historical and scientific perspective. The worldwide eradication of smallpox, with the elimination of the necessity of vaccination, inspires the hope in everyone that other diseases, eg, polio, no longer would cause illness. It was with this mind-set that I approached Dr Behbehani's story. Each of this paperback book's six chapters is carefully subdivided into distinct sections, giving an organized approach and easy reference to specific topics. Selected references are listed at the end of each chapter. As stated in the title, the book contains pictures, which are black-and-white and, unfortunately, many times not of the best quality. Extensive captions are present under each picture and sometimes are too lengthy. A six-page index at the end of the book completes the very orderly format. Chapter 1, "The Early Period," covers in chronological
Effect of Digitalis in Patients Receiving Reserpine
Authors: BERNARD LOWN, LEE EHRLICH, BERNARD LIPSCHULTZ, JOHN BLAKE
Journal: Circulation (1961)

RECENTLY, we encountered an unusual response to digitalis.A patient with rheumatic valvular disease, congestive heart failure, and atrial fibrillation exhibited simul- taneously evidence regarded by some as due to underdigitalization and by others as the result of overdigitalization.During mild exer- tion, the ventricular rate accelerated from 70 to 140 beats per minute with development of a pulse deficit suggesting inadequate digitalization.At the same time, however, this patient developed ventricular bigeminy with multi- form complexes suggesting digitalis intoxica- tion (fig.1).In order to clarify this anoma- lous situation, a digitalis tolerance test was performed with acetyl strophanthidin.'The first small increment of acetyl strophanthidin provoked ventricular bigeminal rhythm (fig.2), a response consistent with digitalis over- dosage.Mild exercise immediately following the test, however, again accelerated the rate to 140, a response compatible with underdigitalization.Thus the paradox of apparent co- existing evidence suggesting both overdigitalization as well as underdigitalization remained unsolved.This patient was receiving many medications.With the exception of reserpine, which was being administered in a daily oral dose of 1.0 mg., none of the other drugs appeared likely to alter the response to digitalis.A search of the literature did not reveal sig- nificant information concerning the effects of reserpine upon the digitalized state.The pres- ent study was therefore undertaken to deter- mine (1) whether reserpine alters the toxic
Effect of Topical Indomethacin on Allergen‐Induced Dual Skin Reactions
Authors: W. Dorsch, X. Baur
Journal: Allergy (1980)

Twelve asthmatics with dual bronchial and skin reactions after allergen challenge received topical treatment with a 5%‐indomethacin cream half an hour before and up to 7h after intradermal allergen and histamine injections. The erythema during the first 20 min of the wheal and flare reaction (WFR) was not affected, neither were the diameters of wheals and flares. 40 to 60 min after injection we observed a marked reduction of the erythema in histamine‐and allergen‐tested skin areas of 10 Patients. This effect lasted up to the 5th h alter injection of high allergen doses. During the hilly developed late cutaneous reactions (LCR) no effect 0f indomethacin on the erythema was observed, the edema of LCR was only insignificantly reduced. These results suggest that the erythema in LCR between the 1st and 4th is caused, at least in part, by local formation of prostaglandins.
Don't forget other medical suppliers
Authors: D. Summers
Journal: BMJ (2011)

Lifestyle or static allocation funds are designed to expose investors to a certain level of risk. The asset allocation is constant and does not change over time. The fund manager’s job is to ensure that the level of risk does not exceed the fund’s target risk. These funds have also been become the popular investment choices in several 401(k) and IRA pension plans. This study looks at the absolute and risk-adjusted performance of three lifestyle mutual fund categories (aggressive, moderate, and conservative) from January 1994 to August 2017 and compares them with various stock and bond benchmark indexes. We find that lifestyle mutual funds have underperformed benchmark indexes and index funds with lower absolute and risk-adjusted performance from January 1994 to August 2017. We also compute the seven-factor alpha (Carhart four factors plus excess returns of FTSE All-World ex US, Barclays Aggregate Bond Index, and Citi World Government Bond Index) during this time period. We find that all three categories of lifestyle funds have negative net alpha during the entire period. Gross alphas for all three lifestyle fund categories are negative, but insignificantly different from zero. These results indicate that lifestyle mutual funds are successful in security selection but charge fees to deliver outperformance that are too high.
Bcr/Abl expression stimulates integrin function in hematopoietic cell lines.
Authors: G Bazzoni, N Carlesso, J D Griffin, M E Hemler
Journal: Journal of Clinical Investigation (1996)

Cell adhesion to the extracellular matrix is largely mediated by adhesion molecules of the integrin family and is often diminished upon oncogenic transformation. However, we show here that the chronic myelogenous leukemia oncogene Bcr/Abl has positive effects on VLA-4 and VLA-5 integrin function. The presence of Bcr/Abl in the GM-CSF- or IL-3-dependent hematopoietic cell lines MO7e, 32D, and BaF/3 enhanced cell binding to both soluble and immobilized fibronectin. The effect was due to enhanced function of the VLA-5 integrin fibronectin receptor and not to increased surface expression. In parallel, Bcr/Abl stimulated cell adhesion to the VLA-4 integrin ligand VCAM-1. Stimulation of VLA-5 function directly correlated with induction of Bcr/Abl tyrosine kinase activity in a temperature-sensitive kinase mutant. Thus, Bcr/Abl stimulates integrin-dependent cell adhesion, by a mechanism involving increased ligand binding, with the tyrosine kinase activity of Bcr/Abl likely playing a key role. Consistent with these results, hematopoietic precursor cells from chronic myelogenous leukemia patients also showed increased adhesion to fibronectin.
Myosin Light Chain Kinase (MYLK) Variants that Confer Increased Risk of Sepsis and Acute Lung Injury are Associated with Asthma and Associated Phenotypes
Authors: L. Gao, A. Grant, P. Chi, P. Gao, M. Stockton, H. Watson, N.N. Hansel, G. Diette, G. Dunston, R.A. Mathias, A. Togias, R. Brower, J. Sevransky, J.P. Maloney, M. Moss, C. Shanholtz, J.G.N. Garcia, T.H. Beaty, K.C. Barnes
Journal: Journal of Allergy and Clinical Immunology (2007)
Public Policy Governing Organ and Tissue Procurement
Authors: Howard M. Nathan
Journal: Annals of Internal Medicine (1996)

Letters1 February 1996Public Policy Governing Organ and Tissue ProcurementHoward M. NathanHoward M. NathanDelaware Valley Transplant Program; Philadelphia, PA 19130Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-3-199602010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The study by Siminoff and colleagues [1] is significant; however, it overlooks the role of the organ procurement organization (OPO) in offering the option of organ donation to the families.A survey of OPOs done last year by the Association of Organ Procurement Organizations showed that when hospital staff approached families and offered the option of donation, the consent rate was about 46%. This figure is consistent with those of Siminoff and colleagues' study. However, when a coordinator from the OPO was on site and involved in requesting donation, the consent rate was about 71%.Former Pennsylvania ...REFERENCE1. Siminoff LA, Arnold RM, Caplan AL, Virnig BA, Seltzer DL. Public policy governing organ and tissue procurement in the United States. Results from the National Organ and Tissue Procurement Study. Ann Intern Med. 1995; 123:10-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Howard M. NathanAffiliations: Delaware Valley Transplant Program; Philadelphia, PA 19130 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProcurement and Allocation of Solid Organs for Transplantation 1 February 1996Volume 124, Issue 3Page: 374KeywordsLegislationPublic policy ePublished: 15 August 2000 Issue Published: 1 February 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evaluation of revised IPSS cytogenetic risk stratification and prognostic impact of monosomal karyotype in 783 patients with primary myelodysplastic syndromes
Authors: Naseema Gangat, Mrinal M. Patnaik, Kebede Begna, Taxiarchis Kourelis, Ryan A Knudson, Rhett P. Ketterling, Janice M. Hodnefield, Curtis A. Hanson, Animesh Pardanani, Ayalew Tefferi
Journal: American Journal of Hematology (2013)

Cytogenetic classification by the revised international prognostic scoring system (IPSS‐R) and the prognostic value of monosomal karyotype (MK) were assessed in 783 patients with primary myelodysplastic syndromes (MDS). At 22 months median follow‐up, 562 (72%) deaths were recorded. Percentages of patients with IPSS‐R “very good,” “good,” “intermediate,” “poor,” and “very poor” cytogenetic categories was 5, 63, 18, 4, and 10%, respectively. The corresponding median survivals were 21, 40, 24, 18, and 6.5 months and the inter‐group differences (good vs. very good/intermediate/poor vs. very poor; P &lt; 0.01) or similarities (very good vs. intermediate vs. poor; P = 0.79) were not significantly modified in multivariable analysis. Results were similar when analysis was restricted to 602 patients managed by supportive care. MK adversely affected survival in both poor and very poor karyotype groups ( P &lt; 0.01). In conclusion, we were unable to confirm the prognostic superiority of IPSS‐R‐very good karyotype or prognostically distinguish between very good, intermediate and poor karyotypes. Furthermore, we show additional prognostic information from MK in poor/very poor karyotype. Am. J. Hematol. 88:690–693, 2013. © 2013 Wiley Periodicals, Inc.
METAPHEN AS A GERMICIDE AND SKIN DISINFECTANT
Authors: GEORGE W. RAIZISS
Journal: JAMA (1930)

The disinfection of the skin of the patient and the hands of the surgeon is still a fundamental problem in operative surgery. Recently, the question of skin disinfection again came under discussion. Interesting work was done by Simmons<sup>1</sup>on the bactericidal action of mercurochrome-220 soluble and iodine solution in skin disinfection. The author determined the relative bactericidal action of various solutions of mercurochrome and iodine on certain pathogenic bacteria which frequently act as skin contaminants. He concludes that tincture of iodine-U. S. P. is far superior to any solution of mercurochrome for use on unbroken skin for disinfection purposes. Rodriguez<sup>2</sup>reported the effect of mercurochrome and iodine on the mucous membrane of the mouth, and his conclusions were that "the 5 per cent mercurochrome solution in alcohol and the mercurochrome-alcohol-acetone preparations possess decided advantages over the aqueous solution, but fail in too large a proportion of cases to
STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS
Authors: René J. Dubos
Journal: The Journal of Experimental Medicine (1939)

In the first paper of this series, a description was given of a cell-free extract, obtained from autolysates of a particular strain of a soil bacillus, which selectively inhibits the growth of all the Gram-positive microorganisms so far tested, and exerts on them a bactericidal effect in vitro. In the present study it is shown that the same agent protects white mice against infection with large numbers of virulent pneumococci. It also exerts a curative effect when administered to mice several hours after injection of the infecting organisms. The degree of protection afforded, and the minimal effective dose of bactericidal agent, are approximately the same for all virulent pneumococci, irrespective of type specificity. The bactericidal agent is entirely ineffective against infection with virulent Friediänder bacilli (type B). This agrees with the fact that the agent does not affect Gram-negative bacilli in vitro. The protective action exerted by the bactericidal agent against experimental pneumococcus infection depends upon the same mechanism which determines its bactericidal effect in vitro.
Review: Current drug treatments do not reduce mortality in idiopathic pulmonary fibrosis
Authors: Randolph J. Lipchik
Journal: Annals of Internal Medicine (2011)

Source Citation Raghu G, Collard HR, Egan JJ, et al; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: Idiopathic pulmonary fibrosis: Evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183:788-824. 21471066
Realizing the Potential of Carotid Artery Stenting
Authors: Gary S. Roubin, Sriram Iyer, Amir Halkin, Jiri Vitek, Christina Brennan
Journal: Circulation (2006)

Carotid artery stenting, compared with carotid endarterectomy, is emerging as an effective and less invasive method of revascularization for extracranial carotid artery stenosis. Carotid stenting is established as the treatment of choice for certain high-risk patient subsets, and ongoing clinical trials are evaluating this method across a broader clinical spectrum, including asymptomatic patients. For carotid stenting to reach its full potential, an acceptable risk of periprocedural complications, particularly in low-risk patients, must be ensured (the "3% rule"). The present article provides an in-depth review of carotid stenting, with special emphasis on the process of risk stratification pertaining to clinical, anatomic, and procedural considerations necessary to optimize procedural safety and patient outcomes.
Spain to ban drinking in the street
Authors: X. Bosch
Journal: BMJ (2002)

The Spanish government is to ban drinking of alcohol in the street and the sale of alcoholic drinks to people aged under 18. The aim is to reduce alcohol misuse among Spanish teenagers and to tackle the nationwide fashion known as “el botellon,” in which young people gather in streets and squares to drink overnight at weekends.

The measure was announced earlier this month by the home secretary, Mariano Rajoy, at the opening of a three day congress on young people, night, and alcohol, held in Madrid under the auspices of the National Plan on Drugs, based at the Home Office.

Mr Rajoy said that the …