tbuckley/cabot-search huggingface dataset:
The Physician-Computer Connection: A Practical Guide to Physician Involvement in Health Care Information Systems
Authors: Bryan P. Bergeron
Journal: Annals of Internal Medicine (1997)

Medical Writings15 July 1997The Physician-Computer Connection: A Practical Guide to Physician Involvement in Health Care Information SystemsBryan P. Bergeron, MDBryan P. Bergeron, MDHarvard Medical School, Boston, MassachusettsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-2-199707150-00053 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Physician-Computer Connection: A Practical Guide to Physician Involvement in Health Care Information SystemsBria WF II, Rydell RL. 124 pages. Chicago: American Hospital Publishing; 1996. $42.50. ISBN 1556481667. Order phone 800-242-2626.Field of medicine: Medical informatics.Format: Softcover book.Audience: All physicians who plan, implement, or use health care information systems, regardless of their technical background. It is a must-read for those involved in health care informatics and hospital administration.Purpose: To provide physicians with a practical, administrative-level guide on how best to take an active, influential role in the development or selection of health care information systems, whether ... Author, Article, and Disclosure InformationAffiliations: Harvard Medical School, Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1997Volume 127, Issue 2Page: 175-176KeywordsClinical decision support systemsCommunication in health careForecastingHealth careHealth informaticsHealth information technologyInformation technologyInternetPatientsTelemedicine ePublished: 15 August 2000 Issue Published: 15 July 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
An unusual variant of granulomatous adnexotropic cutaneous T-cell lymphoma
Authors: A. Garcovich, S. Garcovich, G. Massi
Journal: British Journal of Dermatology (2003)

Sir, A 40‐year‐old man reported the slow progressive appearance, during the previous 6 years, of pruritic erythematous lesions on the trunk, buttock, abdomen, axilla, genital area and forearm (Fig. 1a). Lesions consisted of follicular papules, comedones, milia and cysts. Lesional areas were alopecic (Fig. 1b), and diffuse alopecia was also present on the scalp and beard area, along with comedones and cysts. The patient reported severe skin dryness, especially in the involved areas. No impairment of salivary or lacrimary function was noted. Serological and haematological tests were all normal or negative. Because of the diffuse presence of cysts and comedones, a diagnosis of chloracne had been made in another institution; the clinical diagnosis was confirmed histologically by the presence of infundibular cysts and a granulomatous foreign body reaction to keratin scales. A further biopsy was performed: the most striking histological feature was a lymphocytic infiltrate involving eccrine glands and coils along with a characteristic epithelial hyperplasia (Figs 1c,d). This picture fits perfectly with that reported in the literature1–3 as being characteristic of syringolymphoid hyperplasia, also known as syringotropic mycosis fungoides or syringotropic cutaneous T‐cell lymphoma (CTCL). The hair follicles were involved by the lymphocytic infiltrate in a manner similar to that of the eccrine glands. Follicles were surrounded by a dense lymphocytic infiltrate, with extensive exocytosis. Occasional Pautrier microabscesses were evident in the follicular sheath. This pattern is that of pilotropic mycosis fungoides, a form of folliculotropic CTCL.4–8 Many follicles were entirely transformed into bizarre undifferentiated basaloid structures5 resembling a neoplasm with follicular differentiation, such as basal cell carcinoma, trichoblastoma or cutaneous lymphadenoma. Numerous infundibular cysts were present, scattered throughout the specimens.
Dietary pattern and 20 year mortality in elderly men in Finland, Italy, and the Netherlands: longitudinal cohort study
Authors: P. Huijbregts, E. Feskens, L. Rasanen, F. Fidanza, A. Nissinen, A. Menotti, D. Kromhout
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To investigate the association of dietary pattern and mortality in international data. <b>Design:</b> Cohort study with 20 years9 follow up of mortality. <b>Setting:</b> Five cohorts in Finland, the Netherlands, and Italy. <b>Subjects:</b> Population based random sample of 3045 men aged 50-70 years in 1970. <b>Main outcome measures:</b> Food intake was estimated using a cross check dietary history. In this dietary survey method, the usual food consumption pattern in the 6-12 months is estimated. A healthy diet indicator was calculated for the dietary pattern, using the World Health Organisation9s guidelines for the prevention of chronic diseases. Vital status was verified after 20 years of follow up, and death rates were calculated. <b>Results:</b> Dietary intake varied greatly in 1970 between the three countries. In Finland and the Netherlands the intake of saturated fatty acids and cholesterol was high and the intake of alcohol was low; in Italy the opposite was observed. In total 1796 men (59%) died during 20 years of follow up. The healthy diet indicator was inversely associated with mortality (P for trend &lt;0.05). After adjustment for age, smoking, and alcohol consumption, the relative risk in the group with the healthiest diet indicator compared with the group with the least healthy was 0.87 (95% confidence interval 0.77 to 0.98). Estimated relative risks were essentially similar within each country. <b>Conclusions:</b> Dietary intake of men aged 50-70 is associated with a 20 year, all cause mortality in different cultures. The healthy diet indicator is useful in evaluating the relation of mortality to dietary patterns. <h3>Key messages</h3> Studying dietary patterns instead of single nutrients in relation to mortality takes into account the intercorrelation of nutrients in the diet A healthy diet, as measured by an indicator based on WHO recommendations, is associated with a reduction of 13% after 20 years in all cause mortality for men aged 50-70 The dietary pattern as a whole is more important than specific dietary components with respect to survival among older people The WHO dietary recommendations for the prevention of chronic diseases seem to be effective The healthy diet indicator is useful for evaluating the relation of dietary patterns and mortality in a cross cultural setting
486 Regression of lymphoma after treatment of hepatitis C virus infection
Authors: S. Lepkov, E. Genrisova, R. Oskanova, V. Volinkina, S. Kosyra, N. Kondrateva, N. Folaleeva, I. Nikitin, G. Storojakov, E. Sholohova, E. Demina
Journal: Journal of Hepatology (2004)
Keep libel laws out of science
Authors: F. Godlee
Journal: BMJ (2009)

I hope all readers of the BMJ are signed up to organised scepticism. It’s not a blog, but it could be. It’s one of the four principles of good science as articulated by Robert Merton nearly 70 years ago. The other three—communalism, universalism, and disinterestedness—are no less important, but I had to turn to Wikipedia to remind me what they were. Merton defined organised scepticism as the requirement that scientific claims be exposed to critical scrutiny before they are accepted.

This wasn’t a new idea. Tony Delamothe reminds us (doi:10.1136/bmj.b2771) that the motto of the Royal Society translates as “Take …
The intestinal microbiome, probiotics and prebiotics in neurogastroenterology
Authors: Delphine M. Saulnier, Yehuda Ringel, Melvin B. Heyman, Jane A. Foster, Premysl Bercik, Robert J. Shulman, James Versalovic, Elena F. Verdu, Ted G. Dinan, Gail Hecht, Francisco Guarner
Journal: Gut Microbes (2012)

The brain-gut axis allows bidirectional communication between the central nervous system (CNS) and the enteric nervous system (ENS), linking emotional and cognitive centers of the brain with peripheral intestinal functions. Recent experimental work suggests that the gut microbiota have an impact on the brain-gut axis. A group of experts convened by the International Scientific Association for Probiotics and Prebiotics (ISAPP) discussed the role of gut bacteria on brain functions and the implications for probiotic and prebiotic science. The experts reviewed and discussed current available data on the role of gut microbiota on epithelial cell function, gastrointestinal motility, visceral sensitivity, perception and behavior. Data, mostly gathered from animal studies, suggest interactions of gut microbiota not only with the enteric nervous system but also with the central nervous system via neural, neuroendocrine, neuroimmune and humoral links. Microbial colonization impacts mammalian brain development in early life and subsequent adult behavior. These findings provide novel insights for improved understanding of the potential role of gut microbial communities on psychological disorders, most particularly in the field of psychological comorbidities associated with functional bowel disorders like irritable bowel syndrome (IBS) and should present new opportunity for interventions with pro- and prebiotics.
Adaptive Mechanisms and Leukemia-Reply
Authors: Carl G. Kardinal
Journal: JAMA (1978)

<h3>In Reply.—</h3> Dr Glickman raises several valid issues in his letter. However, the object of our study was to identify the adaptive coping mechanisms of adult acute leukemia patients in remission. It indeed was determined that return to the hospital was a stress-provoking situation associated with the inescapable realization of the presence of the disease. From a practical standpoint of patient management, we are now attempting to administer leukemia maintenance chemotherapy on an outpatient basis whenever possible so that the patient can continue a reasonably normal life-style. Patients with malignant diseases do form a hospital family and show a great deal of true concern for each other.<sup>1</sup>This is an important part of their support system. They tend to visit each other in their homes, help each other with their hobbies, and communicate openly with regard to the nature of their disease. A grief reaction experienced by the group
Noninvasive Determination of Infarct Artery Patency By Cine Magnetic Resonance Angiography
Authors: W. Gregory Hundley, Geoffrey D. Clarke, Charles Landau, Richard A. Lange, John E. Willard, L. David Hillis, Ronald M. Peshock
Journal: Circulation (1995)

Background In survivors of myocardial infarction, restoration of antegrade flow in the infarct artery reduces morbidity and mortality. At present, coronary artery patency must be assessed invasively with contrast angiography. A noninvasive method of evaluating infarct artery patency would be useful in managing survivors of infarction. This study was performed to determine whether magnetic resonance (MR) imaging could reliably assess infarct artery patency in this patient population. Methods and Results Eighteen survivors of myocardial infarction (11 men and 7 women, aged 35 to 74 years) who were consecutively referred for cardiac catheterization underwent contrast coronary angiography and cine MR coronary angiography. Sequential overlapping images of the infarct artery were acquired with cine MR during 15- to 20-second periods of breath-holding. In each study, proximal, middle, and distal segments of infarct arteries were classified as having antegrade, collateral, or no flow. The infarct artery was the left anterior descending in 10 patients, the right anterior descending in 7, and the circumflex in 1. When compared with the results of contrast angiography, MR imaging correctly identified the presence or absence of antegrade flow in the infarct artery of all 18 patients. In addition, cine MR coronary angiography with presaturating pulses correctly established the presence or absence of collateral filling of the distal portion of occluded arteries in 6 of 7 subjects. Conclusions In survivors of myocardial infarction, cine MR coronary angiography can reliably determine the patency and direction of flow in the infarct artery.
Prolonged action of pindolol.
Authors: P D Nigam, A S Malhotra
Journal: BMJ (1973)

ing they may fear, rightly or wrongly, that he will be unsym-pathetic, and even remove them fromn his list.However, whatever reservations one may have about the Department's circular-and we have many-the mere fact that guidance has been issued represents a victory for the Patients Association.-Iam, etc.,
Personal statement syndrome
Authors: Trisha Greenhalgh
Journal: BMJ (2004)

My friend's 12 year old son wanted to give up music lessons. Sure, said his dad, but tell me why. Didn't he like the teacher? Was there too much pressure? Had he stopped enjoying the violin? “Dad,” replied the child, “I never liked music, but I reckon I'm good enough now to put it on my CV.”

Last month, I attended a school concert and heard a 17 year old play a concerto by …
Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2
Authors: Hee Jeong Kong, Min Jung Park, SunHwa Hong, Hyun Jung Yu, Young Chul Lee, Young Hyun Choi, JaeHun Cheong
Journal: Hepatology (2003)

Hepatitis B virus X protein (HBx) is a transcriptional coactivator that plays a significant role in the regulation of genes involved in inflammation and cell survival. A recently identified cellular coactivator, activating signal cointegrator 2 (ASC–2), is enriched in liver cancer cells and associates with many transcription factors that are active in hepatocytes. The tissue colocalization of these 2 proteins, in view of their similar regulatory functions, led us to examine whether HBx and ASC–2 cooperate in transcriptional activation of gene expression. Glutathione S –transferase (GST) pull–down assays and mammalian 2–hybrid analysis show that the transactivation domain of HBx interacts with the C–terminal domain of ASC–2. In fact, these 2 proteins associated in a ternary complex that included the transcriptional activator retinoid X receptor (RXR). Mechanistically, on expression of HBx, the half–life of the ASC–2 coactivator is observed to increase in concordance with the observed increase in ASC–2–dependent coactivation of transcription. In conclusion, these results show that HBx stabilizes the cellular coactivator ASC–2 through direct protein–protein interaction, affecting the regulation of genes actively transcribed in liver cancer cells.
Targeted Delivery of Small Interfering RNA: Approaching Effective Cancer Therapies
Authors: Kathleen F. Pirollo, Esther H. Chang
Journal: Cancer Research (2008)

Three of the primary requirements for the development of effective dual-targeting therapeutic modalities for the treatment of cancer are the tumor-targeted delivery of the therapeutic molecules of interest to the tumor site(s) in the body (both primary and metastatic), passage of the molecular therapeutic through the cell membrane, and targeting specifically a growth or apoptotic pathway. However, lack of efficient targeted delivery, low transfection efficiency, instability to nucleases, poor tissue penetration, and nonspecific immune stimulation have hindered the translation of small interfering RNA (siRNA) into clinical applications. The development of a systemically administered, tumor-specific immunoliposome nanocomplex with high transfection efficiency could overcome these limitations and thus realize the potential of siRNAs to become effective anticancer clinical modalities.
Quantitative DNA. Comparative studies of a cellular marker for bronchogenic carcinoma
Authors: R. L. Teplitz
Journal: JAMA (1983)

During the course of induction of bronchogenic carcinoma in a colony of standard-bred beagles, serial cytologic and biopsy material was obtained under direct bronchoscopy. Cytological changes followed the sequence from metaplasia to carcinoma, closely simulating those features observed in humans, but with subtle differences characterized as species variations. Quantitative DNA done by image analysis correlated directly with the severity of cytologic atypia and also corresponded well with data obtained from humans. Equivalent studies in human bronchogenic carcinoma have shown similar results and strongly suggest that graded hyperploidy accurately reflects atypia in the lung and qualifies as an interspecies tumor marker.
Atopic dermatitis in adolescent boys is associated with greater psychological morbidity compared with girls of the same age: the Young-HUNT study
Authors: M. Saunes, I. Smidesang, T.L. Holmen, R. Johnsen
Journal: British Journal of Dermatology (2007)

Background Having atopic dermatitis (AD) as well as other chronic diseases is often associated with reduced mental health. Adolescents with AD are thought to be especially vulnerable, but few studies have included an ample number of young people. Objectives To study self‐reported mental distress among boys and girls 13–19 years of age with AD compared with mental distress among healthy adolescents as well as mental distress among adolescents with other chronic diseases or complaints, such as headache, neck or shoulder pain, asthma, allergy and rhinitis. Methods The Young‐HUNT study was conducted as a cross‐sectional, population‐based survey in 1995–97. All students in Nord‐Trondelag County, Norway, aged 13–19 years were invited, and some 89% participated. A questionnaire on mental and somatic health, life‐style and social conditions was completed during one school hour. Results A total of 4384 girls and 4433 boys participated. The prevalence of mental distress was higher among older teenagers, and more than every fourth girl aged 17–19 reported mental distress. Although more girls than boys reported mental distress, AD, headache and neck or shoulder pain, the odds for reporting both AD and mental distress were higher for boys [odds ratio (OR) = 2·1 (1·6–2·9)] compared with girls [OR = 1·3 (1·1–1·6)]. A corresponding sex difference in reporting mental distress was also seen for some other chronic diseases or complaints. Conclusions In adolescents aged 13–19 years there was a strong and significant association between self‐reported mental distress and AD as well as headache and neck or shoulder pain for both sexes. Although boys reported fewer complaints as AD, they perceived the complaints a heavier burden than did the girls.
The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10.
Authors: K Sastry, G A Herman, L Day, E Deignan, G Bruns, C C Morton, R A Ezekowitz
Journal: The Journal of Experimental Medicine (1989)

The human mannose-binding protein (MBP) plays a role in first line host defense against certain pathogens. It is an acute phase protein that exists in serum as a multimer of a 32-kD subunit. The NH2 terminus is rich in cysteines that mediate interchain disulphide bonds and stabilize the second collagen-like region. This is followed by a short intervening region, and the carbohydrate recognition domain is found in the COOH-terminal region. Analysis of the human MBP gene reveals that the coding region is interrupted by three introns, and all four exons appear to encode a distinct domain of the protein. It appears that the human MBP gene has evolved by recombination of an ancestral nonfibrillar collagen gene with a gene that encodes carbohydrate recognition, and is therefore similar to the human surfactant SP-A gene and the rat MBP gene. The gene for MBP is located on the long arm of chromosome 10 at 10q11.2-q21, a region that is included in the assignment for the gene for multiple endocrine neoplasia type 2A.
Company challenges melatonin sales ban
Authors: C. Dyer
Journal: BMJ (1996)

A pharmaceutical company that makes melatonin–hailed by the United States media as a miracle “anti-aging” product–is to challenge the Medicines Control Agency's ban on over the counter sales in Britain.

Pharma-Nord, based in Morpeth, Northumberland, will seek leave this month for a High Court judicial review of the ban. The agency claims that the product, which is made from soya beans, has medicinal properties and should not be sold without …
Weight Loss, Exercise, or Both and Physical Function in Obese Older Adults
Authors: Dennis T. Villareal, Suresh Chode, Nehu Parimi, David R. Sinacore, Tiffany Hilton, Reina Armamento-Villareal, Nicola Napoli, Clifford Qualls, Krupa Shah
Journal: New England Journal of Medicine (2011)

Obesity exacerbates the age-related decline in physical function and causes frailty in older adults; however, the appropriate treatment for obese older adults is controversial.In this 1-year, randomized, controlled trial, we evaluated the independent and combined effects of weight loss and exercise in 107 adults who were 65 years of age or older and obese. Participants were randomly assigned to a control group, a weight-management (diet) group, an exercise group, or a weight-management-plus-exercise (diet-exercise) group. The primary outcome was the change in score on the modified Physical Performance Test. Secondary outcomes included other measures of frailty, body composition, bone mineral density, specific physical functions, and quality of life.A total of 93 participants (87%) completed the study. In the intention-to-treat analysis, the score on the Physical Performance Test, in which higher scores indicate better physical status, increased more in the diet-exercise group than in the diet group or the exercise group (increases from baseline of 21% vs. 12% and 15%, respectively); the scores in all three of those groups increased more than the scores in the control group (in which the score increased by 1%) (P<0.001 for the between-group differences). Moreover, the peak oxygen consumption improved more in the diet-exercise group than in the diet group or the exercise group (increases of 17% vs. 10% and 8%, respectively; P<0.001); the score on the Functional Status Questionnaire, in which higher scores indicate better physical function, increased more in the diet-exercise group than in the diet group (increase of 10% vs. 4%, P<0.001). Body weight decreased by 10% in the diet group and by 9% in the diet-exercise group, but did not decrease in the exercise group or the control group (P<0.001). Lean body mass and bone mineral density at the hip decreased less in the diet-exercise group than in the diet group (reductions of 3% and 1%, respectively, in the diet-exercise group vs. reductions of 5% and 3%, respectively, in the diet group; P<0.05 for both comparisons). Strength, balance, and gait improved consistently in the diet-exercise group (P<0.05 for all comparisons). Adverse events included a small number of exercise-associated musculoskeletal injuries.These findings suggest that a combination of weight loss and exercise provides greater improvement in physical function than either intervention alone. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT00146107.).
Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold
Authors: Kian-Ngiap Chua, Wei-Seng Lim, Pengchi Zhang, Hongfang Lu, Jie Wen, Seeram Ramakrishna, Kam W. Leong, Hai-Quan Mao
Journal: Biomaterials (2004)