Successful Management with Intravenous Immunoglobulins of Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Undetermined Significance
Authors: Neeraj Agarwal, Mary M. Klix, C. Patrick Burns
Journal: Annals of Internal Medicine (2004)

Letters6 July 2004Successful Management with Intravenous Immunoglobulins of Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Undetermined SignificanceNeeraj Agarwal, MD, Mary M. Klix, MD, and C. Patrick Burns, MDNeeraj Agarwal, MDFrom University of Iowa Hospitals and Clinics, Iowa City, IA 52242., Mary M. Klix, MDFrom University of Iowa Hospitals and Clinics, Iowa City, IA 52242., and C. Patrick Burns, MDFrom University of Iowa Hospitals and Clinics, Iowa City, IA 52242.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-1-200407060-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Editor's Note:The lead author of the following Clinical Observation was one of a dozen Associates of the American College of Physicians selected to present a clinical vignette at the 2003 Annual Session in Philadelphia. We are proud to present this case report through a special arrangement with the Council of Associates of the College.TO THE EDITOR:Background: While congenital von Willebrand disease is common (1% of the population), its acquired form is relatively rare and accounts for only up to 5% of patients with clinical von Willebrand disease (1). It usually occurs in elderly patients who often present with ...References1. Kumar S, Pruthi RK, Nichols WL. Acquired von Willebrand's syndrome: a single institution experience. Am J Hematol. 2003;72:243-7. [PMID: 12666134] CrossrefMedlineGoogle Scholar2. Federici AB, Rand JH, Bucciarelli P, Budde U, van Genderen PJ, Mohri H, et al . Acquired von Willebrand syndrome: data from an international registry. Thromb Haemost. 2000;84:345-9. [PMID: 10959711] CrossrefMedlineGoogle Scholar3. Vincentelli A, Susen S, Le Tourneau T, Six I, Fabre O, Juthier F, et al . Acquired von Willebrand syndrome in aortic stenosis. N Engl J Med. 2003;349:343-9. [PMID: 12878741] CrossrefMedlineGoogle Scholar4. Kumar S, Pruthi RK, Nichols WL. Acquired von Willebrand disease. Mayo Clin Proc. 2002;77:181-7. [PMID: 11838652] CrossrefMedlineGoogle Scholar5. Federici AB, Stabile F, Castaman G, Canciani MT, Mannucci PM. Treatment of acquired von Willebrand syndrome in patients with monoclonal gammopathy of uncertain significance: comparison of three different therapeutic approaches. Blood. 1998;92:2707-11. [PMID: 9763553] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Iowa Hospitals and Clinics, Iowa City, IA 52242. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcquired Von Willebrand SyndromeSplenic Marginal Zone Lymphoma with Acquired von Willebrand Syndrome Diagnosed via Splenic BleedingLong-term remission of acquired von Willebrand syndrome associated with multiple myeloma using bortezomib and dexamethasone therapyDistinct mechanisms account for acquired von Willebrand syndrome in plasma cell dyscrasiasMaintaining hemostasis in acquired von Willebrand syndrome: a review of intravenous immunoglobulin and the importance of rituximab dose schedulingAcquired Disorders of Platelet FunctionSystemic manifestations of monoclonal gammopathyRituximab et traitement des maladies auto-immunes et inflammatoires systémiquesIs rituximab effective in acquired von Willebrand syndrome?Acquired Disorders of Platelet Function 6 July 2004Volume 141, Issue 1Page: 83-84KeywordsAntibodiesAntigensAutoantibodiesBlood plasmaHemorrhageIntravenous immunoglobulinPartial thromboplastin timeResearch laboratoriesThrombinvon Willebrand disease ePublished: 6 July 2004 Issue Published: 6 July 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...