tbuckley/cabot-search huggingface dataset:
PULMONARY LESIONS IN HODGKIN'S DISEASE
Authors: Robert Charr
Journal: JAMA (1941)

The case of Hodgkin's disease which we present was interesting in that hemoptysis was one of the symptoms and in that the disease was almost entirely limited to the right lung. <h3>REPORT OF CASE</h3><h3>History.—</h3> A white woman aged 23 was admitted to the White Haven Sanatorium in March 1940. She complained of pain in the right side of the chest, dyspnea, cough, expectoration and hemoptysis. The illness began in July 1939 with pain in the right side of the chest. Soon dyspnea began. Cough and expectoration with occasional hemoptysis followed. <h3>Physical Examination.—</h3> Nutrition and color were poor. The cervical lymph nodes were palpable on both sides. The chest showed signs of effusion on the right side with displacement of the heart toward the left. The abdomen showed no masses or ascites. The blood pressure was 108 systolic and 70 diastolic. The temperature was 99 to 102 F.,
Efficacy of interferon treatment for patients with chronic hepatitis C: Comparison of response in cirrhotics, fibrotics, or nonfibrotics
Authors: Gregory T. Everson, Donald M. Jensen, John R. Craig, Dirk J. van Leeuwen, Vincent G. Bain, Murray N. Ehrinpreis, Donald Albert, Tenshang Joh, Karsten Witt
Journal: Hepatology (1999)

Chronic hepatitis C patients (472 patients) were treated with consensus interferon (CIFN) or interferon (IFN) alfa-2b for 6 months in a large multicenter trial. Efficacy was assessed by clearance of hepatitis C virus (HCV) RNA using reverse transcription polymerase chain reaction (RT-PCR) (&lt;100 copies/mL), normalization of serum alanine aminotransferase (ALT), and histological improvement. The purpose of these analyses was to compare these efficacy parameters in nonfibrotics, fibrotics, and cirrhotics. Patients with chronic HCV and cirrhosis showed the same benefit from IFN treatment as noncirrhotic patients when efficacy was assessed by clearance of serum HCV RNA or by histological benefit. Sustained HCV RNA response rates were similar when measured among nonfibrotic (11%), fibrotic (13%), and cirrhotic (11%) patients. Improvement in histologic activity index (HAI) scores was noted among all 3 groups. Cirrhotic patients had a lower sustained ALT response rate (12%) than did nonfibrotic patients (23%). Ninety percent of nonfibrotics, but only 71% of fibrotics and 67% of cirrhotics, who sustained a virological response normalized their ALT. This suggests that cirrhotic patients may clear the hepatitis C virus without normalization of ALT levels. The pattern of both HCV RNA clearance over time and ALT decrease was similar among nonfibrotics, fibrotics, and cirrhotics. Tolerability to IFN therapy was similar among the 3 groups except that more cirrhotics required dose reduction because of thrombocytopenia. In patients with cirrhosis, ALT levels may be a less appropriate endpoint in the measurement of response to therapy. We conclude that liver cirrhosis should not be a reason for excluding patients from therapy because both cirrhotic and fibrotic HCV patients benefit from IFN therapy not only by clearance of virus but by improvements in liver histology.
Correction: Prevalence and Causes of Blindness and Low Vision in Southern Sudan
Authors: Jeremiah Ngondi, Francis Ole-Sempele, Alice Onsarigo, Ibrahim Matende, Samson Baba, Mark Reacher, Fiona Matthews, Carol Brayne, Paul M Emerson
Journal: PLoS Medicine (2007)

In PLoS Medicine, volume 3, issue 12, doi:10.1371/journal.pmed.0030477:

In the Methods and Findings section of the Abstract, the figures 18/60 in the following sentence are incorrect and should read 6/18 to be consistent with what is in the main text of the article:

“Prevalence of blindness (presenting VA of less than 3/60 in the better eye) was 4.1% (95% confidence interval [CI], 3.4–4.8); prevalence of low vision (presenting VA of at least 3/60 but less than 18/60 in the better eye) was 7.7% (95% CI, 6.7–8.7); whereas prevalence of monocular visual impairment (presenting VA of at least 18/60 in better eye and VA of less than 18/60 in other eye) was 4.4% (95% CI, 3.6–5.3).”

Please note that this error does not change the data or the conclusions in the paper. It is an error in the abstract only.
Cutaneous lymphadenoma: a case report and review of the literature
Authors: R. BOTELLA, R.M. MACKIE
Journal: British Journal of Dermatology (1993)

Journal Article Cutaneous lymphadenoma: a case report and review of the literature Get access R. BOTELLA, R. BOTELLA Department of Dermatology, University of Glasgow, Glasgow G12 HQQ, Scotland, UK Search for other works by this author on: Oxford Academic Google Scholar R.M. MACKIE R.M. MACKIE Department of Dermatology, University of Glasgow, Glasgow G12 HQQ, Scotland, UK Professor R.M. MacKie. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 128, Issue 3, 1 March 1993, Pages 339–341, https://doi.org/10.1111/j.1365-2133.1993.tb00181.x Published: 01 March 1993 Article history Accepted: 11 September 1992 Published: 01 March 1993
CHAUCER AND DERMATOLOGY.
Authors: J. D. ROLLESTON
Journal: British Journal of Dermatology (1933)

Journal Article CHAUCER AND DERMATOLOGY. Get access J. D. ROLLESTON, MD., F.R.C.P., F.S.A. J. D. ROLLESTON, MD., F.R.C.P., F.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 45, Issue 2, 1 February 1933, Pages 62–65, https://doi.org/10.1111/j.1365-2133.1933.tb10142.x Published: 01 February 1933
Hepatocyte collagen production in vivo in normal rats.
Authors: M Chojkier
Journal: Journal of Clinical Investigation (1986)

Although hepatocytes produce collagen in vitro, their contribution to hepatic collagen synthesis in vivo is unknown. To answer this question, we injected rats intraperitoneally with [3H]proline and [14C]ornithine. [3H]Proline labeled prolyl-t-RNA in both hepatocytes and nonparenchymal cells. In contrast, [14C]ornithine was rapidly converted to [14C]arginine via the urea cycle only in hepatocytes, labeling arginyl-t-RNA. Approximately 60% of the 14C in albumin and transferrin was present as arginine while the remainder was found in proline and related amino acids. As expected for proteins that have the same proline/arginine ratio and that are produced solely by the hepatocyte, the [3H]proline/[14C]arginine ratio was very similar in albumin and transferrin. Conversely, in nonparenchymal cells a negligible percentage of 14C was present as arginine. A sizeable percentage of the 14C in hepatic collagen was present as arginine; given the greater proline(+hydroxyproline)/arginine ratio in hepatic collagen, our data indicate that in normal rats, hepatocytes contribute most of newly synthesized hepatic collagen.
Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells
Authors: Amanda L. Blasius, Winfried Barchet, Marina Cella, Marco Colonna
Journal: The Journal of Experimental Medicine (2007)

Lymphoid organs contain a B220+CD11c+NK1.1+ cell population that was recently characterized as a novel dendritic cell (DC) subset that functionally overlaps with natural killer (NK) cells and plasmacytoid DCs (PDCs). Using Siglec-H and NK1.1 markers, we unambiguously dissected B220+CD11c+ cells and found that PDCs are the only professional interferon (IFN)-α–producing cells within this heterogeneous population. In contrast, B220+CD11c+NK1.1+ cells are a discrete NK cell subset capable of producing higher levels of IFN-γ than conventional NK cells. Unlike DCs, only a minute fraction of B220+CD11c+NK1.1+ cells in the spleen expressed major histocompatibility complex class II ex vivo or after stimulation with CpG. Consistent with being a NK cell subset, B220+CD11c+NK1.1+ cells depended primarily on interleukin 15 and common cytokine receptor γ chain signaling for their development. In terms of function, expression of distinctive cell surface receptors, and location in lymphoid organs, NK1.1+B220+CD11c+ appear to be the murine equivalent of human CD56bright NK cells.
Management of acute and chronic HCV infection in persons with HIV coinfection
Authors: Mark S. Sulkowski
Journal: Journal of Hepatology (2014)

Due to shared routes of transmission, acute and chronic infection with hepatitis C virus is common among persons living with HIV infection in many regions of the world. In the era of effective antiretroviral therapy, acute HCV infection has been increasingly recognized in HIV-infected persons, particularly men who have sex with men, and liver disease, including hepatocellular carcinoma, has emerged as a leading cause of morbidity and mortality in those with chronic HCV infection, particularly older adults with long-standing coinfection. Over the past decade, the foundation for the management of acute and chronic HCV infection has been interferon alfa. However, due the high burden of treatment-related side effects and low likelihood of sustained virologic response, the impact of treatment with peginterferon/ribavirin on the burden of HCV disease in has been limited. However, the anticipated availability of safe, tolerable and highly efficacious interferon-free, oral HCV direct-acting antiviral combination therapies promise to dramatically change the management of acute and chronic HCV infection in HIV-infected persons. Preliminary data from studies of such oral DAA regimens in HIV/HCV coinfected patients suggest that coinfection with HIV will not impair HCV cure with these regimens. Indeed, in the coming era of high effective oral HCV DAA treatments, the only special feature concerning treatment of acute and chronic HCV infection in HIV-infected patients may be drug interactions between the antiretroviral drugs for HIV infection and direct-acting antiviral drugs for HCV infection.
SANITARY MOTES AND BEAMS.Opening Address of the Section on Hygiene, Climatology and Demography, Pan-American Medical Congress, by the President.
Authors: ALBERT L. GIHON
Journal: JAMA (1893)

"And why beholdest thou the mote that is in thy brother's eye, but considerest not the beam that is in thine own eye?"—(St. Luke, vi., 41-42.) These words of the Teacher of humanity which "the Beloved Physician" of the first century has recorded, are an appropriate text for the opening address in the important Section with whose conduct I have been charged in this Congress. Time was—and that no long time—when Hygeia, the neglected Cinderella of the medical family, slunk unnoticed among menials. Now that she graces the salon her proud sisters caress her and suitors court her favor. As an old admirer of this fair mistress whose colors I have worn through youth and manhood, I may be pardoned the personal exultation that I have lived to see her suzeraine. The ascendency of hygiene has greatened and glorified medicine without dimming the luster of any other branch, but though
Dopamine Receptor Agonist Drugs and Impulse Control Disorders
Authors: Howard D. Weiss, Gregory M. Pontone
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma
Authors: C Renné, K Willenbrock, J I Martin-Subero, N Hinsch, C Döring, E Tiacci, W Klapper, P Möller, R Küppers, M-L Hansmann, R Siebert, A Bräuninger
Journal: Leukemia (2007)
Expanded<i>C9ORF72</i>Hexanucleotide Repeat in Depressive Pseudodementia
Authors: Kevin F. Bieniek, Marka van Blitterswijk, Matthew C. Baker, Leonard Petrucelli, Rosa Rademakers, Dennis W. Dickson
Journal: JAMA Neurology (2014)

Expanded hexanucleotide repeats in C9ORF72 are a common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. Repeat expansions have also been detected infrequently in other disorders, including Alzheimer disease, dementia with Lewy bodies, and parkinsonian disorders.
Employment status and health after privatisation in white collar civil servants: prospective cohort
Authors: J. E Ferrie
Journal: BMJ (2001)

<h3>Abstract</h3> <b>Objectives:</b> To determine whether employment status after job loss due to privatisation influences health and use of health services and whether financial strain, psychosocial measures, or health related behaviours can explain any findings. <b>Design:</b> Data collected before and 18 months after privatisation. <b>Setting:</b> One department of the civil service that was sold to the private sector. <b>Participants:</b> 666 employees during baseline screening in the department to be privatised. <b>Main outcome measures:</b> Health and health service outcomes associated with insecure re-employment, permanent exit from paid employment, and unemployment after privatisation compared with outcomes associated with secure re-employment. <b>Results:</b> Insecure re-employment and unemployment were associated with relative increases in minor psychiatric morbidity (mean difference 1.56 (95% confidence intervals interval 1.0 to 2.2) and 1.25 (0.6 to 2.0) respectively) and having four or more consultations with a general practitioner in the past year (odds ratio 2.04 (1.1 to 3.8) and 2.39 (1.2 to 4.7) respectively). Health outcomes for respondents permanently out of paid employment closely resembled those in secure re-employment, except for a substantial relative increase in longstanding illness (2.25; 1.1 to 4.4). Financial strain and change in psychosocial measures and health related behaviours accounted for little of the observed associations. Adjustment for change in minor psychiatric morbidity attenuated the association between insecure re-employment or unemployment and general practitioner consultations by 26% and 27%, respectively. <b>Conclusions:</b> Insecure re-employment and unemployment after privatisation result in increases in minor psychiatric morbidity and consultations with a general practitioner, which are possibly due to the increased minor psychiatric morbidity.
Doctors, Drugs, and Driving — Tort Liability for Patient-Caused Accidents
Authors: George J. Annas
Journal: New England Journal of Medicine (2008)

The author discusses the case of Coombes v. Florio, in which the Massachusetts Supreme Judicial Court overturned a trial judge's ruling to dismiss a lawsuit against a physician whose patient was the driver in a car accident that resulted in the death of a child. The trial judge had ruled that physicians' responsibilities were restricted to their patients, whereas the court ruled that the victim of a car accident can sue the driver's physician if the physician has failed to inform the patient about medication side effects that may impair driving.
Cardiovascular Actions of Sodium Nitroprusside in Animals and Hypertensive Patients
Authors: IRVINE H. PAGE, A. C. CORCORAN, H. P. DUSTAN, THEODORE KOPPANYI
Journal: Circulation (1955)

Certain chemical and pharmacological properties of sodium nitroprusside, a cheap, readily available chemical, have been described. It is a powerful hypotensive agent when given intravenously tohypertensive patients. It is no more effective than the sodium thiocyanate into which it is converted when given by mouth. Prolonged infusion has proved highly effective in the treatment of hypertensive encephalopathy.
Prescribed drug therapy and near-fatal asthma attacks
Authors: C Burgess, N Pearce, R Thiruchelvam, R Wilkinson, C Linaker, K Woodman, J Crane, R Beasley
Journal: European Respiratory Journal (1994)

Inhaled fenoterol has been associated with an increased risk of death in severe asthmatics, when compared to other adrenoceptor agonists. It is plausible that fenoterol may also increase the risk of near-fatal attacks. We have conducted a case-control study to investigate this hypothesis. The cases comprised Intensive Care Unit (ICU) admissions for asthma in the Wellington region during 1977-1988. For each of these cases, two age-matched controls were selected from asthma admissions to the same hospital during the same period. For the 155 cases and 305 controls, information on prescribed drug therapy was collected from the hospital admission records. The relative risk of a near-fatal asthma attack in patients prescribed inhaled fenoterol was 2.00 (95% confidence interval (CI) 1.35-2.97). An increased risk was also observed for oral theophylline (odds ratio (OR) = 1.88; 95% CI 1.26-2.79). For the 65 cases and 104 controls who had a previous admission for asthma in the previous 12 months, information relating to the previous admission was also collected; an increased risk was once again observed for inhaled fenoterol (OR = 2.18; 95% CI 1.10-4.33) and for oral theophylline (OR = 1.18; 95% CI 0.99-3.57). No other asthma drugs showed significantly increased risks. Although the ICU admission cases had generally been prescribed more asthma drugs than the hospital admission controls, and appeared to have more severe asthma, it is possible that the findings reported here are influenced by confounding by severity. We nevertheless estimate that our findings are consistent with the hypothesis that fenoterol increases the risk of near-fatal asthma attacks, and that they complement previous findings on fatal asthma attacks.(ABSTRACT TRUNCATED AT 250 WORDS)
Mechanisms of Coronary Microcirculatory Dysfunction in Patients With Aortic Stenosis and Angiographically Normal Coronary Arteries
Authors: Kim Rajappan, Ornella E. Rimoldi, David P. Dutka, Ben Ariff, Dudley J. Pennell, Desmond J. Sheridan, Paolo G. Camici
Journal: Circulation (2002)

Background — Development of left ventricular hypertrophy in aortic stenosis (AS) is accompanied by coronary microcirculatory dysfunction, demonstrated by an impaired coronary vasodilator reserve (CVR). However, evidence for regional abnormalities in myocardial blood flow (MBF) and the potential mechanisms is limited. The aims of this study were to quantitatively demonstrate differences in subendocardial and subepicardial microcirculation and to investigate the relative contribution of myocyte hypertrophy, hemodynamic load, severity of AS, and coronary perfusion to impairment in microcirculatory function. Methods and Results — Twenty patients with isolated moderate to severe AS were studied using echocardiography to assess severity of AS, cardiovascular magnetic resonance to measure left ventricular mass (LVM), and PET to quantify resting and hyperemic (dipyridamole 0.56 mg/kg) MBF and CVR in both the subendocardium and subepicardium. In the patients with most severe AS (n=15), the subendocardial to subepicardial MBF ratio decreased from 1.14±0.17 at rest to 0.92±0.17 during hyperemia ( P &lt;0.005), and subendocardial CVR (1.43±0.33) was lower than subepicardial CVR (1.78±0.35; P =0.01). Resting total LV blood flow was linearly related to LVM, whereas CVR was not. Increase of total LV blood flow during hyperemia (mean value, 89.6±59.6%; range, 17% to 233%) was linearly related to aortic valve area. The decrease in CVR was related to severity of AS, increase in hemodynamic load, and reduction in diastolic perfusion time, particularly in the subendocardium. Conclusions — CVR was more severely impaired in the subendocardium in patients with LVH attributable to severe AS. Severity of impairment was related to aortic valve area, hemodynamic load imposed, and diastolic perfusion rather than to LVM.
AN EXPERIMENTAL STUDY OF DIATHERMY
Authors: Ronald V. Christie, Carl A. L. Binger
Journal: The Journal of Experimental Medicine (1927)

The principles governing the passage of high frequency currents through various conductors have been discussed and exemplified in experiments done on both non-living and living bodies. In Part I it was shown: (1) That the current takes the path of least electrical resistance rather than the shortest path; (2) that maximal heating occurs at the point of greatest concentration of the lines of current flow. In a homogeneous medium with parallel electrodes maximal heat production occurs in those portions of the medium adjoining the electrodes and the heat gradient is from without inward. Under these circumstances maximal heating never occurs at the center. In discussing the localization of heat not only the electrical resistance and current concentration, but also the cooling effect, must be considered. In experiments on the dog's cadaver no evidence of the so called "skin effect" could be demonstrated. This is in contradistinction to the findings of Bettman and Crohn, but the discrepancy is explained on the basis of what we believe to be a technical error in their work. The finding of no "skin effect" is in agreement with the conclusions of Dowse and Iredell, based on both experimental and theoretical considerations. In Part II three types of experiments were performed on the anesthetized dog. The conclusions to be derived from them are these: (1) The heat gradient of the body is reversed during diathermy and heating occurs from without inward; (2) deep heating during diathermy is greater than that which results from the application of local heat to the skin; (3) the lung can be heated by diathermy in spite of simultaneous cooling of the chest wall. These experiments we regard as satisfactory evidence of the passage of the current through the interior of the body.
New Technologies in Metabolic Bone Disease
Authors: R. E S Gray
Journal: Annals of the Rheumatic Diseases (1991)

It is encouraging to note that blind and disabled people who are unable to use 'phone books will not have to pay for calls to directory inquiries when British Telecom introduces a charge in 1991, but they will benefit nevertheless from new lower call charges being introduced at the same time.Under the new arrangements blind and disabled people will first have to register with British Telecom using a free linkline number 0800 919195.After certification by a health or community worker they will be issued with a card with large print or braille if necessary.A new three digit number will be set up linking calls to a special bureau in Sheffield specifically designed to answer their inquiries.They will then have to give their PIN number and name.As soon as their PIN has been validated they can ask for their two directory inquiry searches as at present.