The Newer Penicillins
Authors: HAROLD J. SIMON
Journal: Annals of Internal Medicine (1962)

Article1 September 1962The Newer PenicillinsII. Clinical Experiences with Methicillin and OxacillinHAROLD J. SIMON, M.D., PH.D., LOWELL A. RANTZ, M.D., F.A.C.P.HAROLD J. SIMON, M.D., PH.D.Search for more papers by this author, LOWELL A. RANTZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-3-344 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction of penicillin revolutionized the treatment of Gram-positive coccal infections. Mortality from pneumococcal and beta hemolytic streptococcal infections became a rarity. Staphylococcal infections also responded to penicillin therapy with almost uniform regularity initially, but the incidence of penicillin resistant infections began to rise even before 1950. As many as 90 per cent of staphylococcal infections seen in hospital settings were associated with penicillin resistant strains by the mid-1950's (1). Treatment was based on combinations of bacteriostatic drugs or on the use of toxic agents which were difficult to administer (2).Treatment failures were not always due to antimicrobial resistance...References1. ELEK SD: Staphylococcus Pyogenes and Its Relation to Disease, E. S. Livingstone, Ltd., London, 1959, p. 506. Google Scholar2. FINLAND M: Recapitulation and discussion, in Antibiotic Therapy for Staphylococcal Diseases. Antibiotic Monographs No. 12, ed. by Welch, H., and Finland, M., Medical Encyclopedia, Inc., New York, 1959, p. 187. Google Scholar3. KEENEMINGHEWCLUFF WRBHLE: Studies of the epidemiology of staphylococcal infection. III. Clinical factors in susceptibility to staphylococcal disease. New Engl. J. Med. 265: 1128, 1961. CrossrefMedlineGoogle Scholar4. ELEK SD: Staphylococcus Pyogenes and Its Relation to Disease, E. S. Livingstone, Ltd., London, 1959, p. 455. Google Scholar5. SIMONRANTZ HJLA: The newer penicillins. I. Bacteriological and clinical-pharmacological investigations with methicillin and oxacillin. Ann. Intern. Med. 57: 335, 1962. LinkGoogle Scholar6. SIMONRANTZ HJLA: Untoward reactions to antimicrobial agents. Ann. Rev. Med. 12: 111, 1961. CrossrefGoogle Scholar7. JEVONS MP: Correspondence. Celbenin-resistant staphylococci. Brit. Med. J. 1: 124, 1961. CrossrefGoogle Scholar8. BARBER M: Methicillin-resistant staphylococci. J. Clin. Path. 14: 385, 1961. CrossrefMedlineGoogle Scholar9. MCELFRESHHUANG AENN: Bone-marrow depression resulting from the administration of methicillin with a comment on the value of serum iron determination. New Engl. J. Med. 266: 246, 1962. CrossrefGoogle Scholar10. DOYLE J: Personal communication. Google Scholar11. HEWITTFINEGOLDMONZON WLSMOT: Untoward side effects with dimethoxyphenylpenicillin. Abstract of paper presented at the First Interscience Conference on Antimicrobial Agents and Chemotherapy, New York City, October 31-November 2, 1961. Google Scholar12. MER-29 and warnings on other drugs. The Medical Letter 4: 7, 1962. Google Scholar13. DOUTHWAITETRAFFORD AHJA: A new synthetic penicillin. Brit. Med. J. 2: 687, 1960. CrossrefMedlineGoogle Scholar14. DOUTHWAITETRAFFORDMCGILLEVANS AHJADAIE: Methicillin. Brit. Med. J. 2: 6, 1961. CrossrefMedlineGoogle Scholar15. A symposium on the new dimethoxyphenyl penicillin: early laboratory and clinical experience with particular reference to resistant staphylococcal disease. State University of New York, Upstate Medical Center, Syracuse, New York, September 7, 1960. Google Scholar16. ALLENROBERTSKIRBY JDEWM: Staphylococcal septicemia treated with methicillin. New Engl. J. Med. 266: 111, 1962. CrossrefMedlineGoogle Scholar17. WOODLEYHALL DWWH: The treatment of severe staphylococcal infections with vancomycin. Ann. Intern. Med. 55: 235, 1961. LinkGoogle Scholar18. SIMON HJ: Die Therapie Schwere Resistenter Staphylokokken-Infektionen. (in German) Praxis 50: 1179, 1961. MedlineGoogle Scholar19. BURNETT JW: Management of pyogenic cutaneous infections. New Engl. J. Med. 266: 164, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Palo Alto, CaliforniaFrom the Division of Infectious Disease, Department of Medicine, Stanford University School of Medicine, Palo Alto, California.Aided by grant E-3371 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Public Health Service.Dr. Simon is a Fellow of the Arthritis and Rheumatism Foundation.Requests for reprints should be addressed to Harold J. Simon, M.D., Stanford Medical Center, 300 Pasteur Drive, Palo Alto, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAgranulocytosis associated with chronic oral administration of cloxacillin for suppression of staphylococcal osteomyelitisNeutropenia after penicillins: Toxic or immune-mediated?Nafcillin Therapy for Staphylococcus aureus EndocarditisOxacillin-induced neutropenia in childrenβ-Lactam-Antibiotica (Penicilline (P), Cephalosporine (C))Granulocytopenia associated with carbenicillinMethicillin: Critical Appraisal after a Decade of ExperienceThe Isoxazolyl Penicillins: Oxacillin, Cloxacillin, and DicloxacillinQuinacillinHematuria and Proteinuria Associated with Methicillin AdministrationComplications associated with antibiotic therapyAnnotationsNewer Antimicrobial Agents Having Current or Potential Clinical ApplicationThe New PenicillinsThe Treatment of Staphylococcal InfectionsThe Newer Penicillins I. Bacteriological and Clinical Pharmacological Investigations with Methicillin and OxacillinHAROLD J. SIMON, M.D., PH.D., LOWELL A. RANTZ, M.D., F.A.C.P. 1 September 1962Volume 57, Issue 3Page: 344-362KeywordsArthritisInfectious diseasesPenicillinPyelonephritisPyodermaStaphylococcal infectionStreptococcal infectionsSuperinfectionsToxic agentsUrticaria Issue Published: 1 September 1962 PDF DownloadLoading ...