Esophageal Exfoliative Cytology
Authors: WALTER C. MACDONALD
Journal: Annals of Internal Medicine (1963)

Article1 September 1963Esophageal Exfoliative CytologyA Neglected ProcedureWALTER C. MACDONALD, M.D., LLOYD L. BRANDBORG, M.D., LILIAN TANIGUCHI, CYRUS E. RUBIN, M.D.WALTER C. MACDONALD, M.D.Search for more papers by this author, LLOYD L. BRANDBORG, M.D.Search for more papers by this author, LILIAN TANIGUCHISearch for more papers by this author, CYRUS E. RUBIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-3-332 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe remarkable accuracy of exfoliative cytology of the esophagus has been reported by a number of authors (1-6) and the relative simplicity of the technique repeatedly emphasized (1-3). The diagnostic limitations of radiology, esophagoscopy, and biopsy are admitted; yet there has been a reluctance to accept esophageal cytology as a routine procedure. Failure of many centers to adopt the technique suggests that further evidence of its value is needed. This paper provides additional data regarding the accuracy and usefulness of esophageal exfoliative cytology.METHODWhile collection of cells from the esophagus is relatively simple, it must be done carefully if...References1. RUBIN CE: Newer advances in the exfoliative cytology of the gastrointestinal tract. Ann. NY Acad. Sci. 63: 1377, 1956. CrossrefMedlineGoogle Scholar2. RUBIN CE: Exfoliative cytology of the esophagus. CA 10: 90, 1960. Google Scholar3. GEPHARTGRAHAM TR: The cellular detection of carcinoma of the esophagus. Surg. Gynec. Obstet. 108: 75, 1959. MedlineGoogle Scholar4. RASKINKIRSNER HFJB: Application of exfoliative cytology to benign and malignant diseases of the stomach and esophagus. Amer. J. Dig. Dis. 6: 978, 1961. CrossrefMedlineGoogle Scholar5. KLAYMAN MI: The diagnosis of esophageal carcinoma by exfoliative cytology, including two cases of cardiospasm associated with carcinoma of the esophagus. Ann. Intern. Med. 43: 33, 1955. LinkGoogle Scholar6. MESSELT OT: Results of the cytologic diagnosis of esophageal cancer by smears from material obtained by esophagoscopy. Acta Un. Int. Cancr. 16: 1364, 1960. Google Scholar7. RUBINBENDITT CEEP: A simplified technique using chymotrypsin lavage for the cytological diagnosis of gastric cancer. Cancer 8: 1137, 1955. CrossrefMedlineGoogle Scholar8. RUBINMACDONALDBRANDBORGTANIGUCHI CEWCLLL: Cytology of the esophagus and stomach, in A Manual of Cytotechnology, National Committee for Careers in Medical Technology, Service Printing Co., Wichita Falls, Texas, 1962. Google Scholar9. JOHNSONKOSSPAPANICOLAOUSEYBOLT WDLGGJF: Cytology of esophageal washings; evaluation of 364 cases. Cancer 8: 951, 1955. CrossrefMedlineGoogle Scholar10. IMBRIGLIALOPUSNIAK JEMS: Cytologic examination of sediment from the esophagus in a case of intra-epidemial carcinoma of the esophagus. Gastroenterology 13: 457, 1949. MedlineGoogle Scholar11. MERENDINOMARK KAHV: An analysis of one hundred cases of squamous cell carcinoma of the esophagus. Part II. With special reference to its theoretical curability. Surg. Gynec. Obstet. 94: 110, 1952. MedlineGoogle Scholar12. STEINER PE: Etiology and histogenesis of esophageal cancer. Cancer 9: 436, 1956. CrossrefMedlineGoogle Scholar13. ELLIS FG: The natural history of achalasia of the cardia. Proc. Roy. Soc. Med. 53: 663, 1960. CrossrefMedlineGoogle Scholar14. LINDVALL N: Hypopharyngeal carcinoma in sideropenic dysphagia. Acta Radiol. 39: 17; 1953. CrossrefMedlineGoogle Scholar15. BENEDICT EB: Carcinoma of the esophagus developing in benign stricture. New Eng. J. Med. 224: 408, 1941. CrossrefGoogle Scholar16. WYNDERBROSS ELIJ: A study of etiological factors in cancer of the esophagus. Cancer 14: 389, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, WashingtonFrom Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington.This investigation was supported by research grant NC-FIDB CS 9350 (C1-C7) from the Field Investigations and Demonstrations Branch, National Cancer Institute, National Institutes of Health, United States Public Health Service. The work of Dr. MacDonald was supported by an indirect traineeship in Gastroenterology, 2A-5099, from the National Institute of Arthritis and Metabolic Diseases, National Cancer Institute, National Institutes of Health, United States Public Health Service. The work of Dr. Brandborg was supported by a direct traineeship, NC-FIDB-T, from the Field Investigations and Demonstrations Branch, National Cancer Institute, National Institutes of Health, United States Public Health Service.Requests for reprints should be addressed to Walter C. MacDonald, M.D., Department of Medicine, Vancouver General Hospital, Vancouver, B. C., Canada. 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