tbuckley/cabot-search huggingface dataset:
Granulocyte Colony-Stimulating Factor and Acute Myocardial Infarction
Authors: Wolf-Rüdiger Schäbitz, Sigrid Nikol, Armin Schneider
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations
Authors: John C. Riches, Conor J. O’Donovan, Sarah J. Kingdon, Fabienne McClanahan, Andrew J. Clear, Donna S. Neuberg, Lillian Werner, Carlo M. Croce, Alan G. Ramsay, Laura Z. Rassenti, Thomas J. Kipps, John G. Gribben
Journal: Blood (2014)
Legionnaires' Disease: Indirect Fluorescent Antibody Test in Diagnosis
Authors: GARY L. LATTIMER
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 May 1980Legionnaires' Disease: Indirect Fluorescent Antibody Test in DiagnosisGARY L. LATTIMER, M.D.GARY L. LATTIMER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-5-708_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: During the past 2 years, evidence has been accumulated to suggest that the indirect fluorescent antibody (FA) test for diagnosing Legionnaires' disease lacks specificity (1-4). Results of indirect FA staining ofLegionella pneumophilaserogroup 1 and the "Legionella-like agents" TATLOCK, HEBA, and WIGA, reported by Hébert and colleagues (5), further document the nonspecificity of this test. Even though the last three agents are not genetically related toL. pneumophila, convalescent sera from guinea pigs infected with TATLOCK, HEBA, and WIGA gave distinct staining ofL. pneumophila. However, guinea pigs infected withL. pneumophiladid not stain TATLOCK...References1. TSAIFRASER TD. The diagnosis of Legionnaires' disease. Ann Intern Med. 1978;89:413-4. Editorial. LinkGoogle Scholar2. ORMSBEEPEACOCKLATTIMERPAGEFISET RMGLP. Legionnaires' disease: antigenic peculiarities, strain differences, and antibiotic sensitivities of the agent. J Infect Dis. 1978;138:260-4. CrossrefMedlineGoogle Scholar3. LATTIMERCEPIL GB. Legionnaires' disease serology: effect of antigen preparation on specificity and sensitivity of the indirect fluorescent antibody test. J Clin Pathol. In Press. Google Scholar4. WILKINSONFARSHYFIKESCRUCEYEALY HCBDL. Measure of immunoglobulin G-, M-, and A-specific titers against Legionella pneumophila and inhibition of titers against nonspecific, Gram-negative bacterial antigen in the direct immunofluorescence test for Legionellosis. J Clin Microbiol. 1979;10:685-9. CrossrefMedlineGoogle Scholar5. HÉBERTMOSSMCDOUGALBOZEMANMCKINNEYBRENNER GCLFRD. The rickettsia-like organisms TATLOCK (1943) and HEBA (1959): bacteria phenotypically similar to but genetically distinct from Legionella pneumophila and the WIGA bacterium. Ann Intern Med. 1980;92:45-52. LinkGoogle Scholar6. . Legionnaires' disease—United States. Morbid Mortal Weekly Rep. 1978;27:439-41. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDisseminated Tuberculosis Caused by Mycobacterium intracellulare (Update)Concurrent Antibody Rises to C psittaci and L pneumophila in a Patient with Psittacosis 1 May 1980Volume 92, Issue 5Page: 708-708KeywordsGuinea pigsLegionella pneumophilaLegionellosisSpecificityStaining Issue Published: 1 May 1980 PDF downloadLoading ...
Abstract 2104: MicroRNA-101 promotes estrogen independent growth and confers tamoxifen resistance in ER positive breast cancer cells
Authors: Mohit Sachdeva, Hailong Wu, Peng Ru, Larn Hwang, Vuong Trieu, Yin Yaun Mo
Journal: Cancer Research (2010)

Abstract MicroRNAs function as key gene regulators capable of silencing gene expression at the posttranscriptional level. It is estimated that over 1/3 protein coding genes are under control of microRNAs. For example, estrogen receptor (ER) is negatively regulated by microRNAs such as miR-22 and miR-206, and a consequence of this suppression causes resistance to tamoxifen, a commonly used clinical anticancer drug for treatment of breast cancer. However, it is not clear whether microRNAs play any role in the estrogen independent growth, leading to intrinsic tamoxifen resistance. In this study, we use an in vivo selection system against a microRNA library. We first infect the ER positive MCF-7 cells with the pooled library and then orthotopically inject them into female nude mice without supplement of estrogen. As expected, MCF-7 cells infected with the library form tumors whereas those infected with vector control form no tumors. Further experiments show that a number of microRNAs including miR-101 are enriched. Importantly, miR-101 alone is able to promote estrogen independent growth and causes tamoxifen resistance. Unlike those microRNAs that confer tamoxifen resistance by targeting ER, miR-101 has no effect on ER expression or its activity. Of considerable interest, miR-101 suppresses cell growth in normal medium, but it promotes cell survival in estrogen free medium. Finally, we show that miR-101 is able to activate Akt in part due to suppression of Magi-2, a scaffold protein involved in regulation of pTEN activity. Hence, direct suppression of Magi-2 by miR-101 would provide a molecular link for miR-101-mediated activation of Akt through suppression of the pTEN activity. Taken together, these results demonstrate a novel function of miR-101. As a result, miR-101 may serve as a biomarker for the subpopulation of ER positive breast cancer patients who are intrinsically resistant to tamoxifen, and furthermore, it may serve as a novel therapeutic target for overcoming the resistance. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2104.
Philip William Hutton
Authors: S. Hutton
Journal: BMJ (2010)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Philip William Hutton Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Reduction of Lower Extremity Clinical Abnormalities in Patients with Non-Insulin-Dependent Diabetes Mellitus
Authors: Debra K. Litzelman
Journal: Annals of Internal Medicine (1993)

Objective: To evaluate the effect of a patient, healthcare provider, and systems intervention on the prevalence of risk factors for lower extremity amputation in patients with non–insulin-dependent diabetes. Design: Blinded, randomized, controlled trial. Setting: Academic general medicine practice. Participants: Of the 395 patients with non–insulin-dependent diabetes who underwent the initial patient assessment, 352 completed the study. Intervention: The 12-month intervention was multifaceted. Patients received foot-care education and entered into a behavioral contract for desired self-foot care, which was reinforced through telephone and postcard reminders. Health care providers were given practice guidelines and informational flow sheets on foot-related risk factors for amputation in diabetic patients. In addition, the folders for intervention patients had special identifiers that prompted health care providers to 1) ask that patients remove their footwear, 2) perform foot examinations, and 3) provide foot-care education. Results: Patients receiving the intervention were less likely than control patients to have serious foot lesions (baseline prevalence, 2.9%; odds ratio, 0.41 [95% CI, 0.16 to 1.00]; P = 0.05) and other dermatologic abnormalities. Also, they were more likely to report appropriate self-foot-care behaviors, to have foot examinations during office visits (68% compared with 28%; P < 0.001), and to receive foot-care education from health care providers (42% compared with 18%; P < 0.001). Physicians assigned to intervention patients were more likely than physicians assigned to control patients to examine patients' feet for ulcers, pulses, and abnormal dermatologic conditions and to refer patients to the podiatry clinic (10.6% compared with 5.0%; P = 0.04). Conclusions: An intervention designed to reduce risk factors for lower extremity amputations positively affected patient self-foot-care behavior as well as the foot care given by health care providers and reduced the prevalence of lower extremity clinical disease in patients with diabetes.
<i>BRCA1</i> and <i>BRCA2</i> Genetic Testing in Hispanic Patients: Mutation Prevalence and Evaluation of the BRCAPRO Risk Assessment Model
Authors: Kristen J. Vogel, Deann P. Atchley, Julie Erlichman, Kristine R. Broglio, Kaylene J. Ready, Vicente Valero, Christopher I. Amos, Gabriel N. Hortobagyi, Karen H. Lu, Banu Arun
Journal: Journal of Clinical Oncology (2007)

The BRCAPRO model, used to predict a family's likelihood of carrying a BRCA1 or BRCA2 mutation, was designed using mutation frequencies of white and Ashkenazi Jewish populations, and may not be applicable to other populations. BRCAPRO was recently validated in African Americans, although has yet to be examined in Hispanics. This retrospective study reports the mutation frequency and spectrum of BRCA1 and BRCA2 mutations in a Hispanic population and evaluates the BRCAPRO model in Hispanics.A descriptive analysis of mutation frequency and spectrum was performed for Hispanic patients who underwent BRCA1 and BRCA2 genetic testing at a single institution. For comparative analysis of the BRCAPRO risk model, Hispanic patients who underwent comprehensive analysis were compared with white controls using area under the receiver operating characteristic curves (AUROC).Fourteen Hispanic individuals who underwent comprehensive analysis were identified to carry a mutation in BRCA1 or BRCA2 (17.9%; 95% CI, 10.2% to 28.3%) and seven individuals had a variant of uncertain significance (9.0%; 95% CI, 12.0% to 30.8%). A total of eight different mutations and three variants were observed within the entire Hispanic population. When evaluating the performance of the BRCAPRO model, the AUROC for Hispanics was 0.774 (95% CI, 0.63 to 0.90), compared with the AUROC of 0.770 (95% CI, 0.65 to 0.89) for whites.Deleterious BRCA1 and BRCA2 mutations occur at considerable frequency within the Hispanic population, many of which have been identified previously in other ethnic populations. The BRCAPRO model appears to perform equally well in Hispanics as in whites.
VITAMIN K FOR THE NEWBORN
Authors: I. Newton Kugelmass
Journal: JAMA (1942)

<h3>To the Editor:—</h3> Is administration of vitamin K to the newborn of clinical value? This question has been answered guardedly by Sanford and associates inThe Journalof February 28 but confidently by Quick in a communication toThe Journalof March 21. The difference of opinion represents the chasm between a clinical and a chemical evaluation of the problem. Not all hemorrhagic manifestations in the newborn are due to acute hypothrombinemia, and not all cases of "hemorrhagic disease of the newborn" are due to diminution in blood prothrombin. The clotting mechanism may be defective in platelets, leading to thrombocytopenic purpura; in platelet function, leading to thrombopathy; in fibrinogen, leading to fibrinogenopenia; in vascular resistance, leading to allergic, infectious or toxic purpura. The clotting mechanism may be normal, and yet bleeding may occur from vascular injury incident to the birth process. In the past, hemorrhagic disease of the newborn was
Angiographic Estimation of Right Ventricular Volume in Man
Authors: RICHARD D. GENTZLER, MICHAEL F. BRISELLI, JAMES H. GAULT
Journal: Circulation (1974)

Although the feasibility of angiographic estimation of right ventricular (RV) volume (V) has been demonstrated, no method has been validated by comparison with independent measurements of volume, and none has been applied to the systematic analysis of RVV characteristics in man. In the present study, postmortem casts of the human RV were used to determine a regression analysis for RVV for biplane frontal and lateral films by the Simpson's rule technique (true volume = 0.749 calculated volume, r = 0.99, see 3.7 ml, for casts ranging in volume from 20 to 115 ml). This method was then employed to estimate RVV from biplane cineangiograms of 32 patients. The validity of RVV measurements in vivo was corroborated by close correlation of stroke volumes estimated independently by angiographic and indicator dilution methods ( r = 0.98, see 4.1 ml). In nine patients with normal RV hemodynamics RV end-diastolic volume (EDV) averaged 81 ml/m 2 (range 63 to 101 ml/m 2 ); ejection fraction (EF) averaged 0.51 (range 0.40 to 0.66), values generally lower than the normal left ventricular EF. Of 14 patients with elevated RV systolic pressure (&gt; 45 mm Hg), normal RV function was evidenced in eight by normal levels of EF and EDV; in the remaining six patients, EF was reduced and EDV was elevated, suggesting that dilatation occurred in these patients as a function of depressed RV myocardial performance. In six patients with left-to-right shunts RV EDV was also increased; however, in these patients normal levels of EF were observed, indicating that the accommodation to volume overload was accomplished through the Starling mechanism. Finally, in six of 13 patients with reduced levels of cardiac output, RV EDV was increased and EF reduced, signifying that impaired RV myocardial function contributed to depression of over-all cardiac performance. It is concluded that the biplane angiographic method provides a practical, accurate means of quantitating RVV characteristics, including the magnitude of volume overload as well as the level of RV myocardial performance.
Letter by Kronish et al Regarding Article, “Residual Arachidonic Acid–Induced Platelet Activation via an Adenosine Diphosphate–Dependent but Cyclooxygenase-1– and Cyclooxygenase-2–Independent Pathway: A 700-Patient Study of Aspirin Resistance”
Authors: Ian M. Kronish, Nina Rieckmann, Daichi Shimbo, Karina W. Davidson
Journal: Circulation (2007)
Condom most popular method of contraception in girls under 16
Authors: Annabel Ferriman
Journal: BMJ (2001)

Half the girls aged under 16 years who attended family planning clinics in 2000-1 chose to use the male condom as their primary method of contraception, and four out of 10 chose the contraceptive pill.

Although many women now rely on their GPs for contraceptive services, a total of 1.3 million women …
Update on the Methods of the U.S. Preventive Services Task Force: Insufficient Evidence
Authors: Diana B. Petitti
Journal: Annals of Internal Medicine (2009)

The U.S. Preventive Services Task Force (USPSTF) seeks to provide reliable and accurate evidence-based recommendations to primary care clinicians. However, clinicians indicate frustration with the lack of guidance provided by the USPSTF when the evidence is insufficient to make a recommendation. This article describes a new USPSTF plan to commission its Evidence-based Practice Centers to collect information in 4 domains pertinent to clinical decisions about prevention and to report this information routinely. The 4 domains are potential preventable burden, potential harm of the intervention, costs (both monetary and opportunity), and current practice. The process and rationale used to select these domains are presented, along with examples of how clinicians might use the information to guide clinical decision making when evidence is insufficient.
Abstract 4213: Defining the role of NF-kB as a target for omega-3 fatty acids in prostate cancer
Authors: Kaitlin A. Whelan, David Cavazos, Linda A. deGraffenried
Journal: Cancer Research (2011)

Abstract Background: Docosahexaenoic acid (DHA), an omega-3 fatty acid, has been shown to enhance anticancer chemotherapies, but the specific mechanisms by which it promotes its anti-cancer effects remain unclear. Recent studies from our laboratory suggest that one important mechanism may be through modulation of NF-κB activity. NF-κB can alter cells by promoting cell proliferation and inflammation, inhibiting apoptosis, and facilitating metastasis. Preliminary data indicate a strong correlation between p65 retention in the cytoplasm and response to omega-3 fatty acids under conditions of androgen deprivation and/or oxidative stress. We hypothesize that regulation of p65 localization in response to cellular stress is an important mechanism by which DHA sensitizes prostate cells to anti-cancer therapies. Methods: To elucidate the relationship between DHA, NF-κB and prostate cancer, we created a stable LNCaP cell line with constitutively active NF-κB, using a shRNA plasmid to knockout IκBα, the inhibitory protein retaining p65 in the cytoplasm. shRNA was stably transfected into LNCaP cells under G418 drug selection, and NF-κB activity assessed by luciferase reporter assays. Results: NF-κB activity in the shRNA IκBα knockout clones was four times greater than that in the vector only control clones. Preliminary data suggest that DHA is not as effective at sensitizing cells to therapeutic agents in cells expressing constitutively active NF-κB due to IκBα inhibition compared to cells expressing normally regulated NF-κB. Studies are on-going to further define the role of NF-κB cellular localization in mediating the anti-cancer effects of DHA in prostate cells. Conclusions: Our preliminary data indicate that cellular localization of the p65 subunit of NF-κB is an important mechanism by which the omega-3 fatty acids DHA sensitize prostate cells to anti-cancer therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4213. doi:10.1158/1538-7445.AM2011-4213
A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib
Authors: Timothy Hansen, Anthony J. Little, Jeffrey J. Miller, Michael D. Ioffreda
Journal: JAMA Dermatology (2013)

<h3>Importance</h3>Nilotinib, a recently approved multitargeted tyrosine kinase inhibitor targeting the BCR-Abl translocation involved in chronic myelogenous leukemia, reportedly produces alopecia according to the package insert, but clinical and histologic descriptions of the alopecia are lacking.<h3>Observations</h3>A 33-year-old woman with chronic myelogenous leukemia developed widespread alopecia involving scalp and body hair within weeks after starting nilotinib therapy. Biopsies revealed perifollicular lymphocytic inflammation and evidence of follicular injury but normal hair density, consistent with a nonscarring alopecia.<h3>Conclusions and Relevance</h3>Nilotinib therapy may induce perifollicular inflammation and widespread persistent alopecia. We present the first clinical and histologic description of this potential adverse effect. Further investigation into the underlying mechanism of this adverse effect may produce insights into the hair growth cycle as well as potential therapeutic targets.
Sickle cell anemia with few painful crises is characterized by decreased red cell deformability and increased number of dense cells
Authors: Samir K. Ballas
Journal: American Journal of Hematology (1991)

Abstract The frequency and severity of the painful sickle cell crisis vary greatly among affected patients. Aside from a high level of Hb F(&gt;20%) there is no established parameter which may modulate the clinical severity of the disease. In this paper we describe two groups of adult patients with homozygous SS and present their characteristics. The division into these two groups was on the basis of relatively low RBC deformability (≤37% of control) and high RBC deformability (&gt;65% of control) in the steady state. None of the patients had α‐gene deletion and all had Hb F level &lt;6.0%. Each patient was followed for a minimum of 3 years. The number of dense cells was quantitated by centrifugation on discontinuous Stractan gradient. RBC deformability index in isotonic medium (DI 290) was determined by ektacytometry and expressed as % of control. The patients with low RBC deformability had significantly less painful crises and more leg ulcers than those patients with high RBC deformability. The average number of dense cells was 22.2% and 9.8% of total circulating cells in the first and second group respectively. Moreover, the group with high red cell deformability had 33% mortality during the study period whereas no deaths occurred in the group with low RBC deformability. The data indicate that there is a subset of patients with SS who have relatively few painful crises despite low Hb F level. We wish to designate these by the acronym MIDDD syndrome: Mild disease as far as painful crises are concerned, I ncreased number of D ense cells, and D ecreased red cell D eformability. In addition these patients have high incidence of leg ulcers, have low incidence of urinary tract infection, and less mortality. Cellular factors seem to contribute to the incidence of painful crises.
A Broader Role for Advance Medical Planning
Authors: Muriel R. Gillick
Journal: Annals of Internal Medicine (1995)

Advance planning for future illness should be broadened from medical care in the event of incompetence to all medical care for the elderly. To plan effectively, patients need an assessment of their overall medical condition: whether they are robust, frail, demented, or dying. They need to understand the kinds of complications often engendered by aggressive treatment, given their underlying status. Given information about their circumstances and their capacity to withstand medical interventions, patients, together with their physicians, need to formulate broad goals for medical care. There are significant barriers to implementing this scheme, but pressure from patients, structural changes in the practice of medicine that create incentives for planning, and educational strategies, including videotaped interviews and role-playing exercises, can facilitate this form of preventive medicine.