tbuckley/cabot-search huggingface dataset:
Prognosis in Myocardial Infarction
Authors: WILLIAM E. BODEN
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 July 1975Prognosis in Myocardial InfarctionWILLIAM E. BODEN, M.D.WILLIAM E. BODEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-1-118 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their paper in the January issue (Ann Intern Med82:35-39, 1975), "Supraventricular Arrhythmias in Acute Myocardial Infarction: Prognostic Importance of Clinical Setting; Mechanism of Production," Dr. Cristal and his associates conclude that "the presence of supraventricular arrhythmias in acute myocardial infarction was associated with a high mortality rate" and, more specifically, that "this increased mortality is confined to those patients with damage to the anterior wall and did not affect the outcome of patients with infarction in the inferior-posterior wall." I am not certain the authors can legitimately conclude that the increased incidence of mortality observed...References1. DESANCTISBLOCKHUTTER RPA: Tachyarrhythmias in myocardial infarction. Circulation 45:681-702, 1972 CrossrefMedlineGoogle Scholar2. LOWNKLEINHERSHBERG BMP: Coronary and precoronary care. Am J Med 46:705-724, 1969 CrossrefMedlineGoogle Scholar3. JAMES T: Pericarditis and the sinus node. Arch Intern Med 110:305-312, 1962 CrossrefMedlineGoogle Scholar4. THADANICHOPRAABER UMC: Pericarditis after acute myocardial infarction. Br Med J 2:135-137, 1971 CrossrefMedlineGoogle Scholar5. JAMES T: Myocardial infarction and atrial arrhythmias. Circulation 47:399-407, 1973 MedlineGoogle Scholar6. SILVERTSSENHOELBAY EBG: Electrocardiographic atrial complex and acute myocardial infarction. Am J Cardiol 31:450-456, 1973 CrossrefMedlineGoogle Scholar7. LIUGREENSPANPICCIRILLO CGR: Atrial infarction of the heart. Circulation 23:331-338, 1961 CrossrefMedlineGoogle Scholar1. CRISTALFREIDBERG NL: The atriogram: a bedside method for recording high grain P waves. Chest 65:554-555, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Intern in Medicine University Hospital Boston, Massachusetts 02118 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1975Volume 83, Issue 1Page: 118-120KeywordsAcute myocardial infarctionArrhythmiaDeath ratesInfarctionMortalityMyocardial infarction Issue Published: 1 July 1975 PDF DownloadLoading ...
Calciferol in Tuberculous Peritonitis with Disseminated Tuberculosis
Authors: P. Ellman, K. H. Anderson
Journal: BMJ (1948)

MEDICAL JOURNALto three times, water was drawn in to capacity and expelled, as dilute dye solution, into a measuring cylinder.The dilute dye, after making up to a measured volume, was compared Table showing the Eflect of Increasing Concentrations of Spirit on the E.S.R. (mm./1 hr.) Amount of Spirit in 1-25 ml. of Citrated Blood No. 0 0 01 ml.0-02 ml.0 03 ml.0 04 ml.
Removal of a Teratomatous "Twin"
Authors: V. Pennell, L. C. Martin
Journal: BMJ (1940)

case r-eported here is that the second fracture occurred two months after the first, and the sequence of events (that is, fracture followed by callus formation) is well illustrated.The condition does not appear to be so generally well known as it ought to be.It has been-confused with osteoma, syphilitic periostitis, and sarcoma, and mistaken diagnosis has had unfortunate sequelae.Thus Watson Jones (1940) cites a case in which a wife instituted divorce proceedings, as she was told the lesion was a syphilitic periostitis.Straus (1932) reports a case in which the entire second metatarsal was excised because of an erroneous diagnosis of sarcoma.Dodd (1933) reports the case of a woman who had a classical Lisfranc amputa- tion of the right foot performed for a march fracture of the second metatarsal mistakenly diagnosed as a sarcoma.Such errors should not occur if due attention is paid to the various x-ray appearances which may be seen, especially that of a spindle-shaped mass of callus or bone on the shaft of the metatarsal, without a line of fracture.The clinical history with absence of trauma is characteris- tic.Treatment consists in the application of a walking plaster for a month, followed by strapping and foot exercises.The prognosis is good.My thanks are due to Dr. W.
Effect of diuretics on allergen-induced contractions of passively sensitized human bronchi in vitro.
Authors: I Pavord, E Holland, D Baldwin, A Tattersfield, A Knox
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Inhaled furosemide has been shown to protect subjects with asthma from bronchoconstriction induced by a wide variety of stimuli, including allergen, but the mechanism of action is controversial. We have used an in vitro model of allergen-induced bronchoconstriction to examine the effects of furosemide and other ion transport inhibitors. Human bronchial rings were passively sensitized by incubation with serum from an atopic donor and were challenged with Dermatophagoides pteronyssinus. Allergen-challenged bronchial rings developed bronchoconstriction which was effectively inhibited by the cysteinyl-leukotriene antagonist ICI 198,615 (10(-7) M) and to a lesser extent by terfenadine (10(-5) M). Assessed over 60 min furosemide 10(-6), 10(-5), and 10(-4) M inhibited contractions by a mean (95% confidence interval [CI]) 7.9% (-23.5, 39.3%, p > 0.05), 44.2% (12.9, 75.2%, p < 0.01), and 86.9% (55.5, 118.3%, p < 0.001) respectively (n = 5). The same concentrations of bumetanide inhibited contractions by 21.5% (-8.4, 51.4%, p > 0.05), 13.6% (-16.3, 43.4%, p > 0.05) and 51.6% (21.7, 81.4%, p < 0.01) respectively (n = 5). The sodium transport inhibitor amiloride and the anion transport inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) were without effect (both 10(-4) M; n = 4). Furosemide increased PGE2 production by the bronchial rings by 134% (95% CI 53, 259%). Indomethacin (3 x 10(-6) M) blocked the furosemide-induced increase in PGE2 production and reduced the protection afforded by 10(-4) M furosemide against allergen-induced contractions from 67.9% to 34.7% (mean difference 33.2%; 95% CI 9.7, 56.6%; p < 0.01; n = 8).(ABSTRACT TRUNCATED AT 250 WORDS)
On WHO's essential medicines process and transparency
Authors: N. Magrini, J. Robertson, K. d. Joncheere, L. Bero
Journal: BMJ (2014)

Barbui and Purgato have critiqued the processes used to select WHO’s list of essential medicines and provided suggestions on how it could be improved.1

As mentioned, reforms in 2001 substantially changed the way that the expert committee reviews submissions, introducing systematic evidence synthesis and appraisal as a requirement, along with an assessment of comparative cost and cost effectiveness. In addition, WHO made the processes transparent, with all submitted data and reviews publicly available, and introduced opportunities for public comment.

The authors raise three major issues regarding …
Ultrasound in the screening of patients with cirrhosis with large varices.
Authors: M Cottone, E Sciarrino, M P Marceno, A Maringhini, G D'Amico, M Traina, M Amuso, L Pagliaro
Journal: BMJ (1983)

Les etudes faites chez 164 malades atteints de cirrhose sans ascite montrent la valeur des ultrasons dans le depistage des varices. L'examen des veines mesenteriques est particulierement interessant, plus que celui des veines porte et splenique. Cet examen inoffensif semble utile et evite des endoscopies plus traumatisantes
MMR vaccination and autism 1998
Authors: A. Nicoll, D. Elliman, E. Ross
Journal: BMJ (1998)

News p 724 

The media excitement and public concern after a Lancet report linking measles, mumps, and rubella (MMR) vaccine with autism1 kindles a sense of deja vu. It is highly reminiscent of similar scares over pertussis in the 1970s,2 which resulted in much suffering and many deaths from pertussis both in Britain and internationally. 2 3

Britain's vaccination programme has hugely reduced the incidence of diphtheria, haemophilus meningitis, measles, polio, pertussis, congenital rubella, and tetanus.4 As the incidence of these diseases has fallen vaccine safety has assumed greater importance, especially in parents' minds. Any safety issue requires cool scientific consideration.3 Here the hypothesis is that MMR leads to a non-specific gut condition permitting the absorption of non-permeable peptides, which in turn cause serious developmental disorders.1 Supportive evidence consists of cases referred to a gastroenterology group. The data published comprises 11 boys and one girl, each with bowel abnormalities and serious developmental regression (nine had autism). In eight children parents reported regression starting shortly after the children received MMR.1

An editorial accompanying the article and a recent review by the World Health Organisation list …
Air pollution and daily mortality in Seoul and Ulsan, Korea.
Authors: J T Lee, D Shin, Y Chung
Journal: Environmental Health Perspectives (1999)

The relationship between air pollution and daily mortality for the period 1991-1995 was examined in two Korean cities, Seoul and Ulsan. The observed concentrations of sulfur dioxide (SO2; mean = 28.7 ppb), ozone (O3; mean = 29.2 ppb), and total suspended particulates (TSP; mean = 82.3 microg/m3) during the study period were at levels below Korea's current ambient air quality standards. Daily death counts were regressed separately in the two cities, using Poisson regression on SO2, O3, and/or TSP controlling for variability in the weather and seasons. When considered singly in Poisson regression models controlling for seasonal variations and weather conditions, the nonaccidental mortality associated with a 50-ppb increment in a 3-day moving average of SO2 concentrations, including the concurrent day and the preceding 2 days, was 1.078 [95% confidence interval (CI), 1.057-1.099] for Seoul and 1.051 (CI, 0.991-1.115) for Ulsan. The rate ratio was 1.051 (CI, 1.031-1.072) in Seoul and 0.999 (CI, 0. 961-1.039) in Ulsan per 100 microg/m3 for TSP, and 1.015 (CI, 1. 005-1.025) in Seoul and 1.020 (0.889-1.170) in Ulsan per 50 ppb for 1-hr maximum O3. When TSP was considered simultaneously with other pollutants, the TSP association was no longer significant. We observed independent pollution effects on daily mortality even after using various approaches to control for either weather or seasonal variables in the regression model. This study demonstrated increased mortality associated with air pollution at both SO2 and O3 levels below the current World Health Organization recommendations.
Inhibition of respiratory syncytial virus replication by vector-derived small interfering RNAs against NS1 protein*1
Authors: W. Zhang, H. Yang, H.San Juan, R. Singam, X. Kong, G. Hellerman, R.F. Lockey, M.E. Peeples, S.S. Mohapatra
Journal: Journal of Allergy and Clinical Immunology (2004)
Two-dimensional echocardiographic--surgical correlation in Ebstein's anomaly: preoperative determination of patients requiring tricuspid valve plication vs replacement.
Authors: A Shiina, J B Seward, A J Tajik, D J Hagler, G K Danielson
Journal: Circulation (1983)

Two-dimensional echocardiographic features were correlated with surgical findings in 25 patients with Ebstein's anomaly (age 7 days to 71 years). There was excellent agreement between echocardiographic and surgical findings. Echocardiographic observations of anterior leaflet tethering and restriction of motion, as well as small functional right ventricle, were the strongest noninvasively obtained indicators for valve replacement surgery. Plication/annuloplasty (plastic repair) was performed in 17 patients. This group differed from the group needing valve-excision surgery in that the anterior leaflet was elongated, was not tethered, and showed large excursion. These observations support the use of two-dimensional echocardiography as an excellent means for preoperative anatomic assessment of Ebstein's anomaly. This method allowed us to determine which patients were amenable to tricuspid valve excision or plastic repair. A noninvasively derived index of anatomic severity is proposed for easier recognition of patient subgroups.
Diagnosis of Herniated Lumbar Disk with Computed Tomography
Authors: Glenn A. Meyer, Victor M. Haughton, Alan L. Williams
Journal: New England Journal of Medicine (1979)

THE indications for computed tomography (CT) in patients with low back and leg pain are expanding as the resolution of the scanners improves. CT is already the procedure of choice for diagnosing lumbar stenosis1 , 2 and facet joint disease.3 In 25 patients scanned in our institution, we have found CT effective in diagnosing unoperated cases of herniated nucleus pulposus. The purpose of this paper is to describe the technique for extending CT to the diagnosis of lumbar disk herniations and to emphasize its value to the surgeon and the patient. In a number of instances we have not only eliminated an . . .
Rosai–Dorfman Disease
Authors: Andrew Tan Eik Hock, Mark Tan Ming Long, Kesavan Sittampalam, David Ng Chee Eng
Journal: Clinical Nuclear Medicine (2010)

Sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease is a rare clinicopathological entity that typically affects young adults, with patients presenting frequently with fever and painless cervical adenopathy. It can mimic lymphoproliferative diseases, and FDG PET/CT typically demonstrates significant FDG avidity in areas of disease. We report a case of a young Chinese woman presenting with pyrexia and painless cervical adenopathy, for which FDG PET/CT performed as part of the diagnostic process demonstrated FDG avid lesions in both nodal and extranodal sites.
Trace Elements in Sickle Cell Disease
Authors: Ananda S. Prasad
Journal: JAMA (1976)

Trace elements in 84 adult patients (38 men and 46 women) with sickle cell disease (SCD) were reflected in clinical and biochemical data. Height was retarded in six men and five women. Eighty percent of the SCD patients in this sample were below the 50th percentile from the normal mean for weight. Twenty-eight men showed a lack of facial and body hair, and five additional subjects showed only scanty facial hair. Whereas zinc in plasma, red blood cells, and hair was decreased, the excretion of zinc in urine was increased in SCD patients as compared to the controls. We believe that one of the mechanisms accounting for zinc deficiency in SCD may be hyperzincuria and that growth retardation and hypogonadism in men so commonly seen in SCD may be related to zinc deficiency.
Improving Volitional Competence Is Crucial for the Efficacy of Psychosomatic Therapy: A Controlled Clinical Trial
Authors: Simon Forstmeier, Heinz Rueddel
Journal: Psychotherapy and Psychosomatics (2007)

&lt;i&gt;Background:&lt;/i&gt; Although skills of will (volitional competences), such as self-motivation or emotion regulation, are particularly necessary for patients with psychiatric and psychosomatic disorders, it is unknown whether volitional deficits can be reduced and thereby the efficacy of psychotherapy increased. We investigated the effect of a group therapy for improving volitional competence in an inpatient rehabilitation program. &lt;i&gt;Methods:&lt;/i&gt; In a controlled clinical trial, patients from a rehabilitation clinic participated either in the volition group therapy in addition to the standard cognitive behavioral therapy (volition group, VG) or in the standard cognitive behavioral therapy (standard group, SG). Patients were tested for volitional competence, depressive symptoms, total psychiatric symptomatology, and physical complaints prior to, at the end of inpatient therapy and after 6 months of follow-up (n = 242). &lt;i&gt;Results:&lt;/i&gt; At the end of inpatient therapy, better improvement in volitional competence was observed in the VG than in the SG [e.g. self-motivation: effect size (ES) 0.96 vs. 0.39; ANCOVA: F(1, 209) = 16.58; p &lt; 0.001]. Patients with greater volitional improvements had a better rehabilitation outcome. In the VG, depressive symptoms as well as total psychiatric symptomatology decreased significantly more than in the SG [ES: 1.18 vs. 0.87, F(1, 207) = 4.68, p &lt; 0.05, and ES 1.12 vs. 0.73, F(1, 205) = 4.68, p &lt; 0.05, respectively], but not physical complaints [ES: 0.62 vs. 0.48, F(1, 207) = 1.08, n.s.]. &lt;i&gt;Conclusions:&lt;/i&gt; Effect size increased in patients with initially low volitional competence and high motivation to participate in a volitional training. These results might lead to a more systematic assessment and training of volitional competence.
Epidemic Tuberculosis
Authors: Joel J. Alpert, Edward Brett
Journal: New England Journal of Medicine (1963)

TUBERCULOSIS has diminished considerably as a major health problem. Yet a reservoir of infection remains, particularly in large urban communities.1 Periodic explosive epidemics are proof enough of this reservoir,2 and children continue to be particularly susceptible to disease from patients with unrecognized active cases. Past experience has shown that tuberculosis in a child usually requires an intimate exposure to an open case.3 This source is most likely to be within the family, and a careful search can be rewarding in as high as 95 per cent of those under one and 87 per cent of those under two years of . . .
Interleukin 2 trial will try to spark flagging immunity of AIDS patients
Authors: Charles Marwick
Journal: JAMA (1983)

The National Institutes of Health is initiating a phase I clinical trial of the lymphokine interleukin 2 (IL-2) that it hopes may revive the immunologic systems of patients with acquired immune deficiency syndrome (AIDS). Behind this approach lie some basic research findings by a number of groups into the immunologic characteristics of the disease. For example, Gerald V. Quinnan, MD, chief of the Division of Virology in the office of biologics of the Food and Drug Administration, and his associates, including Alain H. Rook, MD, have found that cytotoxic T lymphocytes from patients with AIDS have a marked depression in their ability to respond to viral infection. (Cytotoxic T lymphocytes are cells especially primed to kill only cells specifically infected by a "priming" agent.) In addition, the investigators have found that natural killer (NK) cells from patients with AIDS are depressed in activity compared with NK cells from normal persons.
Oesophageal Obstruction and Coma Due to Nodular Goitre
Authors: A. G. Beckett, A. G. Ellerker
Journal: BMJ (1957)

TUBERCULOUS PLEURAL EFFUSIONSJBOUrn 865 it is possible that all subsequent development of tuber- culosis will be prevented.The superiority of this long-term chemotherapy has become very widely recognized in other forms of tuberculosis (Hoyle et al., 1955; Borthwick, 1956; Ross and Kay, 1956).It is disappointing that residual pleural thickening was as common among those treated with chemotherapy as among those treated without.Possibly early aspiration (Mackay-Dick and Rothnie, 1954) or the administration of corticosteroids (Sors and Trocmd, 1954; Brdil et al., 1955) migbt lessen this complication, which nevertheless did not cause any disability to patients so affected in this series. Conclusions and SmmaryAnti-tuberculosis chemotherapy should be given to all patients with primary tuberculous pleural effusions.Its chief effect is to prevent the development of subsequent forms of tuberculosis: for complete suppression it is probable that treatment should last for at least one year.It is less effective in the early manifestations of the effusion, and does not reduce the incidence of residual pleural thickening.The frequency of post-primary tuberculosis following the use of chemotherapy in primary tuberculous effusions has been assessed in only two published series.In the present investigation 56 patients with such effusions and without obvious parenchymatous foci at the time have been followed, most of them for over five years.Thirty-two were treated with bed-rest alone and in nine (28%) subsequent forms of tuberculosis developed.Twenty-four had received chemotherapy for periods of from two and a half to six months in addition; in most, daily streptomycin and para-aminosalicylic acid were given.Only two patients (8%) developed forms of tuberculosis later.Residual pleural thickening was equally common in both groups.Chemotherapy had little effect upon the early mani- festations, but there was bias in the original selection of cases.I am grateful to the physicians of the London Chest Hospital, under whose care these patients were, and particularly to Dr. E. H. Hudson, Dr. N. L. Rusby, and Dr. J. Smart for their interest.I am indebted to many physicians and hospitals for their help in the follow-up.The above investigations
PRIOR SMOKING STATUS, CLINICAL OUTCOMES, AND THE COMPARISON OF TICAGRELOR WITH CLOPIDOGREL IN ACUTE CORONARY SYNDROMES &amp;ndash; INSIGHTS FROM THE PLATELET INHIBITION AND PATIENT OUTCOMES (PLATO) TRIAL
Authors: Jan Hein Cornel, Richard Becker, Shaun Goodman, Steen Husted, Hugo Katus, Anwar Santoso, Philippe Steg, Robert Storey, Marius Vintila, jie sun, Jay Horrow, Lars Wallentin, Robert Harrington, Stefan James
Journal: Journal of the American College of Cardiology (2012)
A Concept of Community Health Services
Authors: Samuel B. Kirkwood
Journal: New England Journal of Medicine (1958)

AS do all activities, community health services demand a periodic evaluation — which is likely to be of most value if it is stimulated by a combination of healthy dissatisfaction and vision. A concept of services for the future, however, is implemented only by dedicated individuals working together. What an evaluation might show and who the individuals might be are worthy of examination.It is always difficult to give a satisfactory categorical definition of public health. It is easier — and more revealing — to study, as examples, a series of episodes in the history of public-health practice.Toward the . . .
AUSCULTATORY PERCUSSION AS A DIAGNOSTIC METHOD
Authors: C. T. Sharpe
Journal: JAMA (1941)

<h3>To the Editor:—</h3> When auscultatory percussion is used as a routine it will be found to be accurate for locating the apex of the heart. It is also of advantage in examination of the lungs. The simplicity of the method and its ready adaptability plus its assured accuracy should warrant its wide usage, especially by the keen diagnostician. To locate the apex of the heart the stethoscope is held on the manubrium sterni, and light percussion is made beginning at the midaxillary line in the fifth left interspace. A definite change in sound will be detected as soon as the percussion reaches the left border of the heart. After the border of the heart is ascertained in each interspace, the distance to the right and left of the midsternal line may be recorded in centimeters. Auscultatory percussion is of advantage also in examining the upper part of the chest anteriorly
1118-83 Pathological features found postmortem in 53 patients with cardiac rupture complicating acute myocardial infarction
Authors: Satoshi Yasuda, Yasuhide Asaumi, Hiroyuki Okumura, Yoritaka Otsuka, Isao Morii, Atsushi Kawamura, Chikao Yutani, Hiroshi Nonogi, Shunichi Miyazaki
Journal: Journal of the American College of Cardiology (2004)
KRAS-G12C Mutation Is Associated with Poor Outcome in Surgically Resected Lung Adenocarcinoma
Authors: Ernest Nadal, Guoan Chen, John R. Prensner, Hiroe Shiratsuchi, Christine Sam, Lili Zhao, Gregory P. Kalemkerian, Dean Brenner, Jules Lin, Rishindra M. Reddy, Andrew C. Chang, Gabriel Capellà, Felipe Cardenal, David G. Beer, Nithya Ramnath
Journal: Journal of Thoracic Oncology (2014)