Leukopenia and Thrombocytopenia Caused by Thiazolidinediones
Authors: Colleen Digman, Andreas K. Klein, Anastassios G. Pittas
Journal: Annals of Internal Medicine (2005)

Letters20 September 2005Leukopenia and Thrombocytopenia Caused by ThiazolidinedionesColleen Digman, MD, Andreas K. Klein, MD, and Anastassios G. Pittas, MDColleen Digman, MDFrom Tufts-New England Medical Center, Boston, MA 02111., Andreas K. Klein, MDFrom Tufts-New England Medical Center, Boston, MA 02111., and Anastassios G. Pittas, MDFrom Tufts-New England Medical Center, Boston, MA 02111.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-6-200509200-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Thiazolidinediones are orally administered drugs used to control hyperglycemia in patients with type 2 diabetes mellitus (1). Although mild dilutional anemia is often seen with thiazolidinedione therapy, no adverse effects of thiazolidinedione on leukocytes or platelets have been described.Objective: To report the first case, to our knowledge, of a patient who developed leukopenia and thrombocytopenia while taking currently approved thiazolidinediones, rosiglitazone, and pioglitazone, given sequentially.Case Report: A 50-year-old woman with a long-standing history of type 2 diabetes mellitus presented with fatigue in the summer of 2003. Her diabetes had been diagnosed in 1988 and ...References1. Pittas AG, Greenberg AS. Thiazolidinediones in the treatment of type 2 diabetes. Expert Opin Pharmacother. 2002;3:529-40. [PMID: 11996632] CrossrefMedlineGoogle Scholar2. Trontell A. Expecting the unexpected—drug safety, pharmacovigilance, and the prepared mind. N Engl J Med. 2004;351:1385-7. [PMID: 15459298] CrossrefMedlineGoogle Scholar3. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239-45. [PMID: 7249508] CrossrefMedlineGoogle Scholar4. Akbiyik F, Ray DM, Gettings KF, Blumberg N, Francis CW, Phipps RP. Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. Blood. 2004;104:1361-8. [PMID: 15130939] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tufts-New England Medical Center, Boston, MA 02111.Disclosures: Consultancies: A.G. Pittas (Takeda); Honoraria: A.G. Pittas (Takeda). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA pilot dose finding study of pioglitazone in autistic childrenNeutropenia in 6 cases of childhood onset type 1 diabetes and its possible mechanismsClinical and molecular characterization of a severe form of partial lipodystrophy expanding the phenotype of PPARγ deficiencyPeroxisome proliferator-activated receptors, metabolic syndrome and cardiovascular diseaseBone-marrow adipocytes as negative regulators of the haematopoietic microenvironmentPeroxisome Proliferator‐Activated Receptor γ Modulation for the Treatment of Type 2 DiabetesExisting and potential therapeutic approaches targeting peroxisome proliferator-activated receptors in the management of Type 2 diabetesToday's challenges and tomorrow's opportunities: ligands to peroxisome proliferator-activated receptors as therapies for type 2 diabetes and the metabolic syndromeInvestigational PPAR-γ agonists for the treatment of Type 2 diabetesGlitazonas e síndrome metabólica: mecanismos de ação, fisiopatologia e indicações terapêuticasCurrent awareness: Pharmacoepidemiology and drug safetyRosiglitazone-induced immune thrombocytopeniaPathological Gambling Associated with Drug Therapy?: Blood Dyscrasias Associated with Thiazolidinediones: Olanzapine Can Cause Metabolic Problems if Used in Mentally Healthy Patients: Flecainide-Induced Neuropathy: Acute Psychosis with an OTC Cold Medicine: Topiramate-Induced Psychosis: SIADH – Caused by SSRI or Nicotine?: Fentanyl Patch AdvisoryRecent Publications on Medications and Pharmacy 20 September 2005Volume 143, Issue 6Page: 465-466KeywordsAdverse reactionsBone marrowFatigueHematocritNeutrophilsPlateletsResearch laboratoriesSerum proteinsSigns and symptomsType 2 diabetes ePublished: 20 September 2005 Issue Published: 20 September 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...