tbuckley/cabot-search huggingface dataset:
Pleural disease during treatment with bromocriptine in patients previously exposed to asbestos
Authors: G Hillerdal, J Lee, A Blomkvist, A Rask-Andersen, M Uddenfeldt, H Koyi, E Rasmussen
Journal: European Respiratory Journal (1997)

Bromocriptine, which is used in the treatment of Parkinson's disease, can cause adverse pleuropulmonary reactions. Exposure to asbestos can result in similar lesions. Fifteen patients with former exposure to asbestos, who developed pleural fibrosis after treatment with bromocriptine, were observed independently in Sweden (11 patients) and Australia (four patients). The patients complained of malaise, often associated with weight loss, dyspnoea, and a disturbing cough. Laboratory values included increased erythrocyte sedimentation rate and a low haemoglobin level. Lung function tests showed a restrictive lung function defect. Chest radiographs showed bilateral pleural fibrosis, with small amounts of fluid in some cases. Soon after bromocriptine was withdrawn, the patients improved clinically, and the laboratory values returned to normal. However, in most cases, pleural fibrosis and a restrictive lung function defect persisted to some extent. In conclusion, in patients who develop pleuropulmonary fibrosis whilst being treated with bromocriptine, former exposure to asbestos should be investigated. Conversely, when pleural changes develop in a patient on bromocriptine and with prior exposure to asbestos, the possible causative role of the drug should be discussed. Special follow-up may be indicated when bromocriptine is planned in a patient with previous asbestos exposure, and if symptoms or signs of pleural fibrosis develop, bromocriptine withdrawal should be considered.
Empirical Versus Tested Antitachycardia Pacing in Implantable Cardioverter Defibrillators
Authors: Anselm Schaumann, Friederike von zur Mühlen, Bernhard Herse, Bernd-Dieter Gonska, Heinrich Kreuzer
Journal: Circulation (1998)

Background —Implantable cardioverter-defibrillators (ICDs) reduce the risk of sudden cardiac death. The objective of this study was to evaluate whether testing of antitachycardia pacing (ATP) for induced ventricular tachycardias (VTs) at predischarge examination can predict ATP success during follow-up. Methods and Results —The study covers 200 consecutive patients who received ICD implants from June 1991 through December 1995. All underwent electrophysiological testing. In 54 patients (ATP tested, group T), ATP terminated induced VTs successfully. In 146 patients (empirically programmed ATP, group E), only ventricular fibrillation could be induced, including 18 with unsuccessful ATP attempts for induced VTs. Disregarding the results of ATP testing, the same ATP scheme was programmed in all patients: three attempts of autodecremental ramp with 81% of the VT cycle length, with 8 to 10 pulses. During a follow-up of 20.4±10 months, 95% of 3819 spontaneous VTs were successfully terminated with ATP in 42 patients of group T. In group E, 90% of 1346 spontaneous VTs in 81 patients were terminated with ATP. Acceleration after ATP occurred in 2% in group T versus 5% in group E. The success for all episodes in individual patients was ≥90% in &gt;60% of the ATP tested and empirically programmed patients. Conclusions —The results of this 200-patient prospective study comparing tested versus empirical ATP show high success (95% versus 90%) for VT termination, with low rates of acceleration. ATP is safe and very effective and should be programmed “on” in all patients regardless of the predischarge EP inducibility.
Functional assessment of myoblast transplantation for cardiac repair with magnetic resonance imaging
Authors: Ewout J. van den Bos, Richard B. Thompson, Anja Wagner, Heiko Mahrholdt, Yoshihisa Morimoto, Louise E.J. Thomson, Lynn H. Wang, Dirk J. Duncker, Robert M. Judd, Doris A. Taylor
Journal: European Journal of Heart Failure (2005)
Conserved Gene Expression Programs Integrate Mammalian Prostate Development and Tumorigenesis
Authors: Colin Pritchard, Brig Mecham, Ruth Dumpit, Ilsa Coleman, Madhuchhanda Bhattacharjee, Qian Chen, Robert A. Sikes, Peter S. Nelson
Journal: Cancer Research (2009)

Abstract Studies centered at the intersection of embryogenesis and carcinogenesis have identified striking parallels involving signaling pathways that modulate both developmental and neoplastic processes. In the prostate, reciprocal interactions between epithelium and stroma are known to influence neoplasia and also exert morphogenic effects via the urogenital sinus mesenchyme. In this study, we sought to determine molecular relationships between aspects of normal prostate development and prostate carcinogenesis. We first characterized the gene expression program associated with key points of murine prostate organogenesis spanning the initial in utero induction of prostate budding through maturity. We identified a highly reproducible temporal program of gene expression that partitioned according to the broad developmental stages of prostate induction, branching morphogenesis, and secretory differentiation. Comparisons of gene expression profiles of murine prostate cancers arising in the context of genetically engineered alterations in the Pten tumor suppressor and Myc oncogene identified significant associations between the profile of branching morphogenesis and both cancer models. Further, the expression of genes comprising the branching morphogenesis program, such as PRDX4, SLC43A1, and DNMT3A, was significantly altered in human neoplastic prostate epithelium. These results indicate that components of normal developmental processes are active in prostate neoplasia and provide further rationale for exploiting molecular features of organogenesis to understand cancer phenotypes. [Cancer Res 2009;69(5):1739–47]
Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma
Authors: E Terpos, M Politou, R Szydlo, E Nadal, S Avery, E Olavarria, E Kanfer, J M Goldman, J F Apperley, A Rahemtulla
Journal: Leukemia (2004)
Abstract 827: Identification of the insulin-like growth factor 2 mRNA binding protein (IGF2BP1) as an important regulator of cIAP1 translation and apoptosis in rhabdomyosarcomas.
Authors: Mame Daro Faye, Tyson Graber, Stephanie Langlois, Kyle Cowan, Martin Holcik
Journal: Cancer Research (2013)

Abstract Rhabdomyosarcoma, a neoplasm characterized by undifferentiated myoblats-like cells, is the most common soft tissue sarcoma of childhood and represents 3-4% of all childhood cancers. IGF2BP1 is an oncofetal protein that was first identified in the rhabdomyosarcoma RD cell line and was shown to be overexpressed in a variety of cancers. Our group has previously identified IGF2BP1 as a potential translation modulator of the cellular inhibitor of apoptosis protein 1 (cIAP1), a key regulator of the NFκB signaling pathway and of caspase-8 mediated cell death in mammalian cells. In this study, we report that IGF2BP1 and cIAP1 expression is upregulated in a panel of rhabdomyosarcoma cell lines. We also show that IGF2BP1 is a positive regulator of cIAP1 translation, specifically through an internal ribosome entry site (IRES) mechanism. Finally, we report that altering the levels of cIAP1 in two rhabdomyosarcoma cell lines, RH36 and RH41, either by IGF2BP1 knock-down or by a Smac mimetic coumpound, sensitizes these cells to TNFα-mediated cell death. Our results identify IGF2BP1 and cIAP1 as important regulators of apoptosis in rhabdomyosarcomas. Citation Format: Mame Daro Faye, Tyson Graber, Stephanie Langlois, Kyle Cowan, Martin Holcik. Identification of the insulin-like growth factor 2 mRNA binding protein (IGF2BP1) as an important regulator of cIAP1 translation and apoptosis in rhabdomyosarcomas. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 827. doi:10.1158/1538-7445.AM2013-827
Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease.
Authors: P Holvoet, G Perez, Z Zhao, E Brouwers, H Bernar, D Collen
Journal: Journal of Clinical Investigation (1995)

The murine monoclonal antibody mAb-1H11 raised against malondialdehyde (MDA)-modified LDL, was used to detect cross-reacting material in human atheromatous tissue and in plasma. MDA-modified LDL levels in plasma were 0.19 +/- 0.02 mg/dl (mean +/- SEM) in 44 control subjects, 0.24 +/- 0.02 mg/dl in 15 patients with chronic stable angina pectoris (P = NS vs LDL cholesterol matched controls), 1.4 +/- 0.1 mg/dl in 60 patients with acute myocardial infarction (P < 0.001 vs controls), and 0.86 +/- 0.11 mg/dl in 22 patients with carotid atherosclerosis (P < 0.001 vs controls). Modified LDL, isolated from pooled LDL of 10 patients, showed a higher electrophoretic mobility on agarose gels, a higher content of thiobarbituric acid reactive substances, and a higher cholesterol/protein ratio than native LDL and had a similar reactivity (antigen/protein ratio) in the assay as the in vitro MDA-modified LDL used for calibration. Its apo B-100 moiety was not fragmented. Uptake of this modified LDL by macrophages resulted in foam cell generation. In conclusion, elevated plasma levels of atherogenic MDA-modified LDL may be a marker for unstable atherosclerotic cardiovascular disease.
Normality and reliability in the clinical assessment of backache.
Authors: G Waddell, C J Main, E W Morris, R M Venner, P S Rae, S H Sharmy, H Galloway
Journal: BMJ (1982)

Article abstract-We examined five individuals and obtained information concerning six other members from two unrelated families, nearly all of whom developed chorea after age 50 (one patient developed chorea at age 40). The severity of chorea progressed in all patients and became disabling in some individuals approximately 15 years after onset. Cognitive impairment was absent or minimal. All five examined patients were cognitively normal, even 10 to 30 years following the onset of chorea. Formal neuropsychometric testing demonstrated mild cognitive impairment in two individuals. Nevertheless, all patients were able to maintain employment or carry on with their usual household tasks until chorea was severe. One individual first became demented 30 years after the onset of chorea. Neuroimaging (with CT or MRI) in four patients failed to demonstrate significant caudate or putaminal atrophy 8 to 15 years following the onset of chorea. Three other family members (who were not available for examination) were said to have suffered chorea (without any mental decline) beginning after age 50, with subsequent survival of 20 years (in one) and 30 years (in two). Given this constellation of history and findings, three experienced neurologists and two medical geneticists concluded that these patients had a familial chorea syndrome distinct from Huntington9s disease (HD). However, genetic analysis of the trinucleotide (CAG) repeat length associated with HD (in 4p16.3) determined repeat lengths of 44 and 46 in four patients tested (within the HD range). We conclude that these patients have HD and that such families represent further convincing examples of significant phenotypic variation for HD. <b>NEUROLOGY 1995;45: </b> 443-447
Ischemic Hepatitis from Aortic Dissection
Authors: Bruce R. Leslie
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 March 1989Ischemic Hepatitis from Aortic DissectionBruce R. Leslie, MD, Lionel H. Head, MD, John C. Scharfenberg, MDBruce R. Leslie, MDSearch for more papers by this author, Lionel H. Head, MDSearch for more papers by this author, John C. Scharfenberg, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-6-495_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The diagnosis of aortic dissection may be complicated by a patient's unusual presentation ( 1 ). We report a case of aortic dissection in which the most prominent abnormalities were due to hepatic ischemia.A 5 3-year-old man was hospitalized for nausea and repetitive vomiting of sudden onset that were followed by dull periumbilical pain. His blood pressure was 240/130 mm Hg, and he had epigastric, periumbilical, and right upper quadrant abdominal tenderness. The aspartate aminotransferase level was 1220 U/L; alanine aminotransferase, 1502 U/L; lactate dehydrogenase, 2626 U/L; alkaline phosphatase, 66 U/L; and total bilirubin, 14 µmol/L....References1. DeSanctisDoroghaziAustenBuckley RRWM. Aortic dissection. N Engl J Med. 1987;317:1060-7. CrossrefMedlineGoogle Scholar2. CelloSleisenger JM. The liver in systemic conditions. In: Zakim D, Boy er TD, eds. Hepatology: A Textbook of Liver Disease. Philadelphia: W. B. Saunders; 1982:1230-1. Google Scholar3. HirstJohnsKirne AVS. Dissecting aneurysm of the aorta: a review of 505 cases. Medicine (Baltimore). 1958;37:217-79. CrossrefMedlineGoogle Scholar4. SlaterDeSanctis ER. The clinical recognition of dissecting aortic aneurysm. Am J Med. 1976;60:625-33. CrossrefMedlineGoogle Scholar5. Mudge G. Case records of the Massachusetts General Hospital. N Engl J Med. 1985;312:1560-7. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ochsner Clinic New Orleans, LA 70121 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDevelopment and Validation of a Diagnostic Model to Predict the Risk of Ischemic Liver Injury After Stanford A Aortic Dissection SurgeryHypoxic hepatitis: a challenging diagnosisHypoxic Liver InjuryThe Liver and Vascular SurgeryType I acute aortic dissection accompanied by ischemic enterocolitis due to blood flow insufficiency in the superior mesenteric arteryMalperfusion of the Thoracoabdominal Vasculature in Aortic Dissection 15 March 1989Volume 110, Issue 6Page: 495-495KeywordsAlanine aminotransferaseBilirubinBlood pressureHepatitis AIschemiaLactate dehydrogenaseNauseaPhosphatasesSerum glutamic oxaloacetic transaminaseVomiting Issue Published: 15 March 1989 PDF downloadLoading ...
Post‐kala‐azar dermal leishmaniasis with mucosal involvement in a kidney transplant recipient: treatment with liposomal amphotericin B
Authors: None Roustan, None JimÉnez, None GutiÉrrez‐Solar, None Gallego, None Alvar, None PatrÓN
Journal: British Journal of Dermatology (1998)

Post-kala-azar dermal leishmaniasis (PKDL) is a rare clinical variant of cutaneous leishmaniasis. It is very common in the Indian subcontinent and less frequent in East Africa, but exceptional in the American and European continents. We have observed a case of PKDL in a renal transplant recipient. No systemic symptoms were present. The patient was treated with liposomal amphotericin B. We emphasize the unusual aspects of this case: the appearance of PKDL in Europe, its relationship with immunosuppression, the severe mucosal involvement and the excellent response to liposomal amphotericin B, a newly described treatment for the disease.
121 MICROBIAL EPIDEMIOLOGY, RISK FACTORS AND OUTCOME OF SBP IN CIRRHOTIC PATIENTS WITH ASCITES
Authors: T. Reiberger, P. Schwabl, T. Bucsics, K. Soucek, B.A. Payer, A. Blacky, A. Hirschl, A. Ferlitsch, M. Peck-Radosavljevic
Journal: Journal of Hepatology (2012)
Inhibition of anaphylatoxin C3a- and C5a- but not nerve stimulation- or Noradrenaline-dependent increase in glucose output and reduction of flow in Kupffer cell-depleted perfused rat livers
Authors: G P Puschel, A Nolte, H L Schieferdecker, E Rothermel, O Gotze, K Jungermann
Journal: Hepatology (1996)

In isolated in situ perfused rat livers, infusion of anaphylatoxins C3a and C5a, activation peptides of the complement system, as well as stimulation of sympathetic hepatic nerves have been shown to increase hepatic glucose output and to reduce hepatic flow. These effects were mediated via an at least partially prostanoid–dependent intercellular signalling chain between nonparenchymal cells and hepatocytes. Kupffer cells have been implicated as the source of prostanoids in the anaphylatoxin–dependent signalling chain and Ito cells in the nerve stimulation–dependent signalling chain, because anaphylatoxins and noradrenaline increased prostanoid synthesis in isolated Kupffer and Ito cells, respectively. To further corroborate this hypothesis, anaphylatoxins were infused and hepatic nerves were stimulated in perfused rat livers in which Kupffer cells had been largely depleted by treatment of the animals with gadolinium chloride. Native human anaphylatoxin C3a (nhC3a) and recombinant rat anaphylatoxin C5a (rrC5a) increased prostanoid formation as well as glucose output and reduced flow in perfused rat liver. In Kupffer cell–depleted rat livers, the nhC3a– and rrC5a–mediated prostanoid formation was nearly abolished, and the increase in glucose output and the reduction of flow were reduced to between 30% and 50% (area under the curve [AUC]) of control livers. In contrast, stimulation of hepatic nerves increased glucose output and reduced flow to a similar extent in Kupffer cell–depleted livers as in control livers. These results indicate that Kupffer cells were not involved in the prostanoid–mediated nerve stimulation–dependent increase in glucose output and reduction of flow. Kupffer cells seemed, however, to be at least one major source of the anaphylatoxin–mediated prostanoid formation and, consequently, stimulation of glucose release and flow reduction in perfused liver. Because the metabolic and hemodynamic anaphylatoxin effects were not completely blocked in livers of gadolinium–treated animals, either Kupffer cells may not have been entirely eliminated, or yet another nonparenchymal cell type and mediator might be involved in the anaphylatoxin–elicited intercellular communication between nonparenchymal cells and hepatocytes.
The Teaching Nursing Home
Authors: Edmund H. Duthie
Journal: JAMA (1982)

ALTHOUGH the teaching nursing home concept has received wide dissemination since publication of an article by Butler, 1 a number of teaching nursing homes already exist in one form or another throughout the country. Some of these programs were shaped from limited resources through innovative thinking and personal energy. As often occurs in academic spheres, however, planned programs are not initiated until funding becomes available. In this article we present one medical school's attempt, by using existing resources, to incorporate fully a nursing home into a geriatric teaching program.  The Medical College of Wisconsin (MCW) is a private, free-standing medical school located in Milwaukee. Milwaukee is an industrial city with a population of almost 700,000,14% of whom are older than 60 years. The Medical College has no single university teaching hospital in which to train its 800 undergraduate students and more than 500 house staff but relies on a group
The Shortage of Hospital Nurses: A New Perspective
Authors: LINDA H. AIKEN
Journal: Annals of Internal Medicine (1981)

There appears to be a critical shortage of hospital nurses in the United States, despite a 15-year national effort to bring the supply of nurses into balance with increased demand. Careful review of supply and requirement data does not provide an adequate explanation for the persistent shortage, and common misconceptions about the nature of the nurse shortage have clouded the debate. Several popular explanations for the shortage do not appear to be valid. Evidence strongly favors the explanation that the shortage has been caused by the depression of nurses' incomes relative to incomes of other workers. The present wage structure has both short- and long-term effects on the shortage of nurses; allowing nurses salaries to rise to levels of comparable workers may be the only solution.
Hemoglobin Titusville, a low oxygen affinity variant hemoglobin, in a family of Northern European background
Authors: Hong‐yuan Luo, Ian Irving, John Prior, Erna Lim, Shawn H. Eung, Timothy P. Skelton, Wendy N. Erber, Martin H. Steinberg, David H.K. Chui
Journal: American Journal of Hematology (2004)

Abstract We report the second case of Hb Titusville in a family of Northern European background. This variant hemoglobin caused by an α‐globin gene mutation has decreased oxygen affinity. Correct diagnosis is clinically important to spare affected individuals extensive investigations into other causes of low oxygen saturation in peripheral blood. Am. J. Hematol. 77:384–386, 2004. © 2004 Wiley‐Liss, Inc.
Intellectual disability and cognitive ability in Darier disease: Swedish nation-wide study
Authors: M. Cederlöf, R. Karlsson, H. Larsson, C. Almqvist, P.K.E. Magnusson, K. Nordlind, M. Landén, P. Lichtenstein
Journal: British Journal of Dermatology (2015)

Journal Article Intellectual disability and cognitive ability in Darier disease: Swedish nation‐wide study Get access M. Cederlöf, M. Cederlöf Department of Medical Epidemiology and Biostatistics Karolinska Institute Stockholm Sweden Correspondence Martin Cederlöf. E‐mail: martin.cederlof@ki.se Search for other works by this author on: Oxford Academic Google Scholar R. Karlsson, R. Karlsson Department of Medical Epidemiology and Biostatistics Karolinska Institute Stockholm Sweden Search for other works by this author on: Oxford Academic Google Scholar H. Larsson, H. Larsson Department of Medical Epidemiology and Biostatistics Karolinska Institute Stockholm Sweden Search for other works by this author on: Oxford Academic Google Scholar C. Almqvist, C. Almqvist Department of Medical Epidemiology and Biostatistics Karolinska Institute Stockholm SwedenLung and Allergy Unit Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden Search for other works by this author on: Oxford Academic Google Scholar P.K.E. Magnusson, P.K.E. Magnusson Department of Medical Epidemiology and Biostatistics Karolinska Institute Stockholm Sweden Search for other works by this author on: Oxford Academic Google Scholar K. Nordlind, K. Nordlind Department of Medicine Karolinska Institute Stockholm Sweden Search for other works by this author on: Oxford Academic Google Scholar M. Landén, M. Landén Department of Medical Epidemiology and Biostatistics Karolinska Institute Stockholm SwedenInstitute of Neuroscience and Physiology University of Gothenburg Gothenburg Sweden Search for other works by this author on: Oxford Academic Google Scholar P. Lichtenstein P. Lichtenstein Department of Medical Epidemiology and Biostatistics Karolinska Institute Stockholm Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 1, 1 July 2015, Pages 155–158, https://doi.org/10.1111/bjd.13740 Published: 01 July 2015
Bilateral Tibial Osteomyelitis in a Patient with Sickle Cell Anemia
Authors: PURUSHOTHAM VELUVOLU, DOUGLAS WENDLAND, THOMAS L. SELL, JOHN G. WEIR, RICHARD W. MILLER, ANDREA GILBERT
Journal: Clinical Nuclear Medicine (1992)

A case of bilateral tibial osteomyelitis in a young black woman with a history of multiple sickle cell crises, suspected of having acute Infarction, is presented. Although the radiographs are inconclusive, bone and gallium studies suggested osteomyelitis with follow-up delayed bone scan consistent with successful antibiotic treatment.