Beta-Adrenergic Receptor Blockade Propranolol and Related Drugs
Authors: STEPHEN E. EPSTEIN
Journal: Annals of Internal Medicine (1967)

Editorials1 December 1967Beta-Adrenergic Receptor Blockade Propranolol and Related DrugsSTEPHEN E. EPSTEIN, M.D., EUGENE BRAUNWALD, M.D., F.A.C.P.STEPHEN E. EPSTEIN, M.D.Search for more papers by this author, EUGENE BRAUNWALD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1333 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPropranolol, the first beta-adrenergic receptor blocking agent to receive approval from the Food and Drug Administration for marketing, will soon be available for general use in the United States. Because of the mass of information that has accumulated relating to the physiological, metabolic, and clinical effects of this type of pharmacologic agent (1), great interest has developed in the clinical application of beta-adrenergic receptor inhibition. However, the widespread enthusiasm attendant upon the imminent availability of drugs that can specifically block beta receptors should be tempered. Although these agents have been shown to have considerable therapeutic efficacy, there is ample evidence...References1. EPSTEINBRAUNWALD SEE: Beta-adrenergic receptor blocking drugs. Mechanisms of action and clinical applications. New Eng. J. Med. 275: 1106, 1175, 1966. CrossrefMedlineGoogle Scholar2. EPSTEINROBINSONKAHLERBRAUNWALD SBFRLE: Effects of beta-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man. J. Clin. Invest. 44: 1745, 1965. CrossrefMedlineGoogle Scholar3. EPSTEINBRAUNWALD SEE: The effect of beta adrenergic blockade on patterns of urinary sodium excretion: studies in normal subjects and in patients with heart disease. Ann. Intern. Med. 65: 20, 1966. LinkGoogle Scholar4. GRANTKEELANKERNOHANLEONARDNANCEKIEVILLSINCLAIR RHPRJJCLK: Multicentre trial of propranolol in angina pectoris. Amer. J. 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COHENBRAUNWALD LSE: Amelioration of angina pectoris in idiopathic hypertrophic subaortic stenosis with beta-adrenergic blockade. Circulation 35: 847, 1967. CrossrefMedlineGoogle Scholar21. HONEYCHAMBERLAINHOWARD MDAJ: The effect of beta-sympathetic blockade on arterial oxygen saturation in Fallot's tetralogy. Circulation 30: 501, 1964. CrossrefMedlineGoogle Scholar22. ABRAMSONARKYWOEBER EARAKA: Effects of propranolol on the hormonal and metabolic responses to insulin-induced hypoglycaemia. Lancet 2: 1386, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEPHEN E. EPSTEIN, M.D.; EUGENE BRAUNWALD, M.D., F.A.C.P.Affiliations: Cardiology Branch National Heart Institute National Institutes of Health Bethesda, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLimitation of Work Performance in Normal Adult Males in the Presence of Beta-Adrenergic BlockadeLong-term propranolol therapy for angina pectorisHerz und Grosse GefässeCirculatory effects of practololHerz und Grosse Gefässe52 Factors That Can Affect Blood Glucose LevelsPhysiology and pharmacology of the coronary circulation and myocardium, particularly in relation to coronary artery diseaseAntihypertensive Agents 1962–1968Chapter 8 Angina Pectoris and Antianginal Agents 1 December 1967Volume 67, Issue 6Page: 1333-1337KeywordsDrug administrationDrug marketingDrugsFood and Drug Administration ePublished: 1 December 2008 Issue Published: 1 December 1967 PDF downloadLoading ...