Angiotensin-Converting Enzyme Inhibitors for Secondary Erythrocytosis
Authors: Fadi Fakhouri, Jean-Pierre Grünfeld, Olivier Hermine, Richard Delarue
Journal: Annals of Internal Medicine (2004)

Letters16 March 2004Angiotensin-Converting Enzyme Inhibitors for Secondary ErythrocytosisFadi Fakhouri, MD, Jean-Pierre Grünfeld, MD, Olivier Hermine, MD, PhD, and Richard Delarue, MDFadi Fakhouri, MDFrom Hôpital Necker, 75015 Paris, France.Search for more papers by this author, Jean-Pierre Grünfeld, MDFrom Hôpital Necker, 75015 Paris, France.Search for more papers by this author, Olivier Hermine, MD, PhDFrom Hôpital Necker, 75015 Paris, France.Search for more papers by this author, and Richard Delarue, MDFrom Hôpital Necker, 75015 Paris, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-6-200403160-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Secondary erythrocytosis is related to an inappropriate secretion of erythropoietin. It has been reported in the setting of chronic hypoxia, neoplasia, and renal transplantation and more rarely in patients with cystic renal diseases. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists have proved to be an alternative to phlebotomy and hydroxyurea in patients with secondary erythrocytosis related to renal transplantation (1), chronic pulmonary disease (2), and altitude (3).Objective: To report what we believe to be the first successful use of ACE inhibitors in patients with erythrocytosis associated with cystic kidney diseases.Case Reports: Patient ...References1. Vlahakos DV, Marathias KP, Agroyannis B, Madias NE. Posttransplant erythrocytosis. Kidney Int. 2003;63:1187-94. [PMID: 12631334] CrossrefMedlineGoogle Scholar2. Vlahakos DV, Marathias KP, Kosmas EN. Losartan reduces hematocrit in patients with chronic obstructive pulmonary disease and secondary erythrocytosis [Letter]. Ann Intern Med. 2001;134:426-7. [PMID: 11242510] LinkGoogle Scholar3. Plata R, Cornejo A, Arratia C, Anabaya A, Perna A, Dimitrov BD, et al . Angiotensin-converting-enzyme inhibition therapy in altitude polycythaemia: a prospective randomised trial. Lancet. 2002;359:663-6. [PMID: 11879862] CrossrefMedlineGoogle Scholar4. Mrug M, Stopka T, Julian BA, Prchal JF, Prchal JT. Angiotensin II stimulates proliferation of normal early erythroid progenitors. J Clin Invest. 1997;100:2310-4. [PMID: 9410909] CrossrefMedlineGoogle Scholar5. Wang AY, Yu AW, Lam CW, Yu LM, Li PK, Goh J, et al . Effects of losartan or enalapril on hemoglobin, circulating erythropoietin, and insulin-like growth factor-1 in patients with and without posttransplant erythrocytosis. Am J Kidney Dis. 2002;39:600-8. [PMID: 11877580] CrossrefMedlineGoogle Scholar6. Glicklich D, Burris L, Urban A, Tellis V, Greenstein S, Schechner R, et al . Angiotensin-converting enzyme inhibition induces apoptosis in erythroid precursors and affects insulin-like growth factor-1 in posttransplantation erythrocytosis. J Am Soc Nephrol. 2001;12:1958-64. [PMID: 11518790] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Hôpital Necker, 75015 Paris, France. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLosartan Reduces Hematocrit in Patients with Chronic Obstructive Pulmonary Disease and Secondary Erythrocytosis Demetrios V. Vlahakos , K.P. Marathias , and E.N. Kosmas Metrics Cited byBlood pressure medicationsCase 23-2010Antihypertensive Medications and AnemiaAnemia in heart failure-A concise review 16 March 2004Volume 140, Issue 6Page: 492-493KeywordsACE inhibitorsAttentionErythropoiesisErythropoietinHematocritKidneysPolycythemiaRenal diseasesRenal transplantationVeins ePublished: 16 March 2004 Issue Published: 16 March 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...