Hyponatremia in Rocky Mountain Spotted Fever: Role of Antidiuretic Hormone
Authors: LISA G. KAPLOWITZ
Journal: Annals of Internal Medicine (1983)

Brief Reports1 March 1983Hyponatremia in Rocky Mountain Spotted Fever: Role of Antidiuretic HormoneLISA G. KAPLOWITZ, M.D., GARY L. ROBERTSON, M.D.LISA G. KAPLOWITZ, M.D., GARY L. ROBERTSON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-334 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRocky Mountain spotted fever is a systemic vasculitis caused by the invasion of vascular endothelial cells by Rickettsia rickettsii. Increased vascular permeability occurs because of endothelial injury often resulting in decreased intravascular volume, hypotension, and in some patients, edema. In its more advanced stages the disease frequently involves several organ systems.Although hyponatremia has been reported widely in Rocky Mountain spotted fever, occurring in over 50% of patients in some series, its mechanism is not known (2). In our study antidiuretic hormone (ADH) levels were elevated relative to plasma hypo-osmolality in four patients with Rocky Mountain spotted fever and hyponatremia....References1. WALKERBRADFORD DW. The current status of Rocky Mountain spotted fever in childhood. In: ROSENBERG HS, BERNSTEIN J, eds. Perspective in Pediatric Pathology. New York: Masson; 1981:35-61. Google Scholar2. KAPLOWITZFISCHERSPARLING LJP. Rocky Mountain spotted fever: a clinical dilemma. In: REMINGTON JS, SWARTZ MN, eds. Current Clinical Topics in Infectious Diseases 2. New York: McGraw-Hill Book Company; 1981:89-108. Google Scholar3. ROBERTSONMAHRATHARSINHA GEST. Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma. J Clin Invest. 1973;52:2340-52. CrossrefMedlineGoogle Scholar4. ORMSBEEPEACOCKGERLOFFTALLENTWIKE RMRGD. Limits of rickettsial infectivity. Infect Immun. 1978;19:239-45. CrossrefMedlineGoogle Scholar5. WALKERCAINOLMSTEAD DBP. Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia rickettsii in cutaneous lesions. Am J Clin Pathol 1978;69:619-23. CrossrefMedlineGoogle Scholar6. ROBERTSONAYCINENAZERBE GPP. Neurogenic disorders of osmoregulation. Am J Med. 1982;72:339-53. CrossrefMedlineGoogle Scholar7. SZATALOWICZARNOLDCHAIMOVITZBICHETBERLSCHRIER VPCDTR. Radioimmunoassay of plasma arginine vasopressin in hyponatremic patients with congestive heart failure. N Engl J Med. 1981;305:263-6. CrossrefMedlineGoogle Scholar8. BICHETSZATALOWICZCHAIMOVITZSCHRIER DVCR Role of vaspressin in abnormal water excretion in cirrhotic patients. Ann Intern Med. 1982;96:413-7. LinkGoogle Scholar9. ZERBESTROPESROBERTSON RLG. Vasopressin function in the syndrome of inappropriate antidiuresis. Ann Rev Med. 1980;31:315-27. CrossrefMedlineGoogle Scholar10. SEXTONCLAPP DJ. Inappropriate antidiuretic hormone secretion: occurrence in a patient with Rocky Mountain spotted fever. Arch Intern Med. 1977;137:262-3. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of North Carolina Chapel Hill, North Carolina University of Chicago Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMurine TyphusTickborne Diseases in Children in the United StatesRocky Mountain Spotted Fever and Other RickettsiosesCase 14-2018: A 68-Year-Old Woman with a Rash, Hyponatremia, and UveitisDiagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis — United StatesRickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)RICKETTSIAL AND EHRLICHIAL DISEASESPathogenesis, Immunity, Pathology, and Pathophysiology in Rickettsial DiseasesThe Order RickettsialesRocky Mountain spotted feverMechanism of low serum sodium levels in Mediterranean spotted feverBiological Variations in 412 Patients with Mediterranean Spotted FeverMurine typhus and spotted fever in israel in the eighties: Retrospective analysisRickettsiosis-associated hyponatremiaSkin InfectionsRocky mountain spotted feverMyocardial disease in Rocky Mountain spotted fever: Clinical, functional, and pathologic findings 1 March 1983Volume 98, Issue 3Page: 334-335KeywordsAntidiuretic hormoneEdemaEndothelial cellsHyponatremiaHypotensionMean corpuscular volumeRickettsiaRocky Mountain spotted feverVascular permeabilityVasculitis Issue Published: 1 March 1983 PDF DownloadLoading ...