tbuckley/cabot-search huggingface dataset:
Functional Identification of Histamine H <sub>3</sub> -Receptors in the Human Heart
Authors: Michiaki Imamura, Nahid Seyedi, Harry M. Lander, Roberto Levi
Journal: Circulation Research (1995)

Abstract Norepinephrine release contributes to ischemic cardiac dysfunction and arrhythmias. Because activation of histamine H 3 -receptors inhibits norepinephrine release, we searched for the presence of H 3 -receptors directly in sympathetic nerve endings (cardiac synaptosomes) isolated from surgical specimens of human atria. Norepinephrine was released by depolarization with K + . The presence of H 3 -receptors was ascertained because the selective H 3 -receptor agonists ( R )α-methylhistamine and imetit reduced norepinephrine release, and the specific H 3 -receptor antagonist thioperamide blocked this effect. Norepinephrine release was exocytotic, since it was inhibited by the N-type Ca 2+ -channel blocker ω-conotoxin and the protein kinase C inhibitor Ro31-8220. Functional relevance of these H 3 -receptors was obtained by showing that transmural electrical stimulation of sympathetic nerve endings in human atrial tissue increased contractility, an effect blocked by propranolol and attenuated in a concentration-dependent manner by ( R )α-methylhistamine. Also, thioperamide antagonized the effect of ( R )α-methylhistamine. Our findings are the first demonstration that H 3 -receptors are present in sympathetic nerve endings in the human heart, where they modulate adrenergic responses by inhibiting norepinephrine release. Since myocardial ischemia causes intracardiac histamine release, H 3 -receptor–induced attenuation of sympathetic neurotransmission may be clinically relevant.
VOMITING IN INFANCY
Authors: T. M. Ling
Journal: BMJ (1929)

A JHE ZXom 197 the amount of glycosuria is said to be usually constant and inidepelndenit of diet an-d the level of the blood sugar.This has niot been true, however, in mny experience of nion- diabetic renal glycosuria.In two of these diabetics the lowered threshold lhas remained constant for five years, and in nione, observed over sliorter periods, has it been found to vary.Theire iS every reason to thinlk, therefore, that the peculiarityis a permanlent one, as renal glycosuria seems to be.IL addition to these eight cases, a lowered threshold appealed temporarily during pregnancy in two diabetic womleni, but became normal again after labour.Practical Importance of tflc Con(lition.These cases seem, on the whole, to follow the same course as diabetes wvith a norimal renial threshold.They have niot seemed more liable to ketosis than other cases, because they htave not lost sutfficient sugar in the iurinie to affect miiateri- aily the ketogenic-antiketogenic ratio of the diet as fed.Butt oue of the pregnant womiien, wlho was losin-g some 30 grams of sugar a day by the thiu mliontlh of pregnanicy owinig to the low threshold, excreted more ketone bodies than previously.The fasting blood sugar level might have beeni expected to be lower tlhan usual from the loss of sugar, but this was not noticeable.However, two of tlhe youngest patienits, who had for y-ears after the original discovery of their diabetes paid little attenitioni to their condition, seemed to deteriorate much less rapidly than the usual careless juvenile diabetic.One of these patients gave little heed to diet for seven years, was thirsty, anid had a blood suigar of niearly 0.3 per cent.when tested, and yet became rapidly controlled on1 diet without in-suiliin, and has remained so since.Another, a girl of 12, had diabetes for seven years witlhouit any marked progression, and always responded at once to dietetic treatment.it seems possible that the low leak point acted in these cases as a safety v alve, which tenided, by the loss of sugar in-the urine, to lower the blood sugar and relieve the strain on the islet cells.This is miy
Report calls for improved systems for employing locums
Authors: S. Chaudhry
Journal: BMJ (2001)

Hospitals should adopt better procedures for checking the qualifications and experience of locum consultants and monitoring their performance, a new report said last week.The Commission for Health Improvement (CHI) asked the Department of Health to consid-er establishing a national database to allow trusts to access doctors' qualifications and to equip all locums with a "passport to practise" through a "smart card" that records their employment history and qualifications.Trusts also needed to ensure
Reducing mortality in myocardial infarction
Authors: Jonathan N Townend, Sagar N Doshi
Journal: BMJ (2005)

command the necessary resources.Matters would improve if the MHRA could require companies to undertake specific studies as a condition of renewal of a marketing authorisation.The last health select committee report on the pharmaceutical industry was published on the day World War I was declared, 12 and its far sighted recommendations such as the registration of all manufacturers, remedies, and therapeutic claims, were ignored in the aftermath.The current wide ranging report correctly identifies many areas of pharmaceutical influence, and the distortions they introduce.The report does not identify the resources to assure that an independent David triumphs over the pharmaceutical Goliath.Unbiased clinical trials, objective drug data, and perfect pharmacovigilance are desirable but probably illusory and certainly expensive.
Abstract 5326: Quantitative molecular profiling of biomarkers for pancreatic cancer with quantum dots
Authors: Peter C. Searson, Kwan Hyi Lee
Journal: Cancer Research (2011)

Abstract The detection of cancer biomarkers is important for diagnosis, disease stage forecasting, and clinical management. Since tumor populations are inherently heterogeneous, a key challenge is the quantitative profiling of membrane biomarkers, rather than secreted biomarkers, at the single cell level. The detection of cancer biomarkers is also important for imaging and therapeutics since membrane proteins are commonly selected as targets. Many methods for detection of membrane proteins yield ensemble averages and hence have limited application for analysis of heterogeneous populations or single cells. Fluorescence-based methods allow detection at the single cell level, however, photobleaching presents a major limitation in obtaining quantitative information. Quantum dots overcome the limitations associated with photobleaching, however, the development of quantum dot – antibody (QD-Ab) conjugates that allow quantitative profiling of biomarkers has remained challenging. Here we demonstrate quantitative in vitro profiling and multiplexing of molecular biomarkers associated with precursor lesions of pancreatic adenocarcinoma using QD-Ab conjugates. We demonstrate quantitative spatial profiling of several biomarkers for pancreatic cancer, including mesothelin, prostate stem cell antigen, and claudin-4 in several pancreatic cancer cell lines and a normal pancreas cell line. We also show tumor targeting in a mouse model. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5326. doi:10.1158/1538-7445.AM2011-5326
455 APOLIPOPROTEIN H IS STRONGLY ASSOCIATED WITH IL28B SNP GENOTYPE AND PREDICTS VIRAL CLEARANCE IN BOTH ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION
Authors: M.E. Laird, A. Mohsen, R. Saleh, D. Duffy, L. Le Fouler, M. El-Daly, M. Rafik, M. Abdel-Hamid, M.K. Mohamed, P. Bonnard, V. Mallet, S. Pol, M. Albert, A. Fontanet
Journal: Journal of Hepatology (2013)
Psychosocial factors and relapse of schizophrenia
Authors: T Davies
Journal: BMJ (1994)

Schizophrenia follows a relapsing course for life in most sufferers. In one study almost 80% of patients relapsed repeatedly, and at five years half showed persistent handicap.1 Relapse takes a toll on patients and their families and imposes a financial burden on hospital and community services.2

Some patients relapse while taking maintenance medication,3,4 and this stimulated a search for other contributory factors which has now led to an emerging consensus.*RF 5-10* What are the psychosocial factors, how do they operate, and what interventions are effective?

The chance of relapse in patients with schizophrenia living at home depends heavily on the emotional environment provided by the family.11 The concept of expressed emotion has evolved as an index of the quality of this environment.*RF 11-13* Expressed emotion covers many of the emotional responses by a key relative, usually the spouse or parent, towards the patient. The key relative's level of expressed emotion is classed as high or low on the basis of the frequency of critical comments and the intensity of hostility and emotional overinvolvement elicited during a structured interview …
A piece of my mind. Mary-go-round
Authors: C. M. Callahan
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Genie in the Bottle
Authors: Michael Bernstein
Journal: Annals of Internal Medicine (1998)

On Being a Patient1 April 1998The Genie in the BottleMichael Bernstein, MDMichael Bernstein, MDMurray Hill, NJ 07974Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the fall of 1992, my 1-year-old granddaughter developed classic erythema infectiosum. Her face took on the typical “slapped cheek” appearance, and she developed fever and malaise. I suspected that her parvovirus B19 would in all likelihood infect her grandfather, and it did: I developed fever and severe joint pains. Even after these symptoms disappeared, however, I felt poorly and could never seem to recover from an increasing sense of fatigue that persisted and even worsened. In 6 weeks, my hemoglobin concentration decreased to 10 g (possibly due to the parvovirus), and I lost 22 pounds. I had no appetite, ... Author, Article, and Disclosure InformationAffiliations: Murray Hill, NJ 07974Corresponding Author: Michael Bernstein, MD, 19 Warren Place, Murray Hill, NJ 07974. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 595-596KeywordsExerciseFallsFearFeversGrowth hormoneHormonesNauseaNeurosurgerySurgeryVision Issue Published: 1 April 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Prospective study of drug reporting by general practitioners for an elderly population referred to a geriatric service.
Authors: W J Gilchrist, Y C Lee, H C Tam, J B Macdonald, B O Williams
Journal: BMJ (1987)

A prospective study was carried out in which the drug history of patients which was provided by general practitioners was compared with the drugs found by geriatricians in patients' homes in 700 referrals to geriatricians. Drug compliance was not assessed. The drug history appeared to be accurate in one third of referrals. Underreporting of medication was common and increased as the number of prescribed drugs increased. Roughly one fifth of patients had at least one potential drug interaction. Keeping careful prescription records, regular review, and accurate reporting of medication should reduce drug associated morbidity in elderly patients.
PREDICTION OF MAJOR ADVERSE CARDIAC EVENTS USING GLOBAL LONGITUDINAL STRAIN ON SPECKLE TRACKING TRANSTHORACIC ECHOCARDIOGRAPHY IN HYPERTROPHIC CARDIOMYOPATHY PATIENTS: A STUDY WITH A MEDIAN OF 29 MONTHS FOLLOW-UP
Authors: Koya Ozawa, Nobusada Funabashi, Hiroyuki Takaoka, Yoshio Kobayashi
Journal: Journal of the American College of Cardiology (2014)
P68. A new EGFR - EpCAM bispecific antibody enhances the efficacy of adoptive T-cell therapy in a murine gastric tumour model
Authors: S Kobold, J Steffen, S Grassmann, R Castoldi, J Schmollinger, C Sustmann, G Nierderfellner, C Klein, C Bourquin, S Endres
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts A limiting step for adoptively transferred tumour-specific T cells is their recruitment from the blood circulation to the proximity of tumour cells and subsequent engagement in direct tumour cell contact. We hypothesised that a bispecific antibody recruiting T cells to a target
Studies of Erythropoiesis in Man Before and After Bilateral Nephrectomy.
Authors: William F. Denny
Journal: Annals of Internal Medicine (1967)

s1 May 1967Studies of Erythropoiesis in Man Before and After Bilateral Nephrectomy.William F. Denny, M.D. (Associate), William J. Flanigan, M.D.William F. Denny, M.D. (Associate)Search for more papers by this author, William J. Flanigan, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1049_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSix patients undergoing preparation for renal transplantation were used in observing the effect of bilateral nephrectomy and splenectomy on erythropoietic mechanisms. All patients were chronically anemic, azotemic, and required periodic transfusions for maintenance of hematocrit levels of 20 to 22%. Simultaneous determinations of ferrokinetic data and red cell survival were carried out using a dual isotope technique. Erythropoietin assays were done by a bioassay using polycythemic mice and59Fe. The effect of the patient's plasma on both exogenous and endogenous erythropoietin was assessed. Erythropoietin activity was absent before (0.37% ± 0.07 SE of the mean) and after nephrectomy (0.42% ±... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tucson, Arizona, and Little Rock, Arkansas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1049-1049KeywordsBioassays and physiological analysisBlood plasmaErythropoiesisErythropoietinHematocritNephrectomyRenal transplantationSplenectomy Issue Published: 1 May 1967 PDF downloadLoading ...
Insulin-Degrading Enzyme Inhibition, a Novel Therapy for Type 2 Diabetes?
Authors: Safia Costes, Peter C. Butler
Journal: Cell Metabolism (2014)

The insulin-degrading enzyme (IDE) has been identified as a type 2 diabetes and Alzheimer's disease susceptibility gene, though its physiological function remains unclear. Maianti et al. (2014) now propose that an IDE inhibitor may be a promising therapeutic strategy for type 2 diabetes.
Photosensitivity to Sunlight from Use of Sulphonamides
Authors: E. Rosen
Journal: BMJ (1948)

BMEDICAL JOURALwere given by mouth for 7 days.By this time the patient was much better though still weak.Temperature was subnormal throughout and there were no joint pains or joint involvement.The pulse was not much affected.There was no special skin reaction at the site of the injections.Trinitrin did not seem to relieve the chest pain.The bowels were not affected.No previous penicillin either by mouth or injection had been administered.Although the chest pain strongly suggested a cardiac origin, particularly the first attack (position of pain, sense of constriction, some radiation to the neck), yet I am not at all certain that it might not be due to an allergic reaction in the upper abdomen in the region of the diaphragm.Which organ caused continuous pain in this case must, however, be a matter of conjecture.It is noteworthy that in the last 20 years the patient has had three attacks of severe epigastric pain lasting about 1-2 hours, probably allergic in origin.This case differs from the two others recently reported in, the absence of a raised temperature and of joint involvement.Also it differs in the presence of chest pain and of, greater gastric disturbance.The onset of severe symptoms took place 221 days after the first injection.-Iam, etc.,
Prevention of Rh-Hemolytic Disease.
Authors: Cyril A. Clarke
Journal: Annals of Internal Medicine (1968)

s1 May 1968Prevention of Rh-Hemolytic Disease.Cyril A. Clarke, F.R.C.P.Cyril A. Clarke, F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1166_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past few years, principally in the United Kingdom, the United States, and Germany, numerous papers have appeared demonstrating that it is possible usually to prevent Rh isoimmunization by giving incomplete anti-D (Rh°) antibody (as anti-D gamma globulin) to previously unsensitized women within 72 hr of the birth of an Rh-positive ABO compatible baby. The passive antibody probably protects against immunization either by coating and thereby inactivating Rh-positive fetal cells that have leaked across the placenta at or near delivery or by a central feedback mechanism by which the passive antibody inhibits the activity of the antibody-producing cells.The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Liverpool, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1166-1166KeywordsBirthCellsGlobulinsPlacenta Issue Published: 1 May 1968 PDF DownloadLoading ...
Early physiological and biological features in three animal models of induced acute lung injury
Authors: Josefina López-Aguilar, María Elisa Quilez, Octavi Martí-Sistac, Carolina García-Martín, Gemma Fuster, Ferranda Puig, Carlos Flores, Jesús Villar, Antonio Artigas, Lluís Blanch
Journal: Intensive Care Medicine (2009)
Renal and Metabolic Effects of Insulin Lispro in Type 2 Diabetic Subjects With Overt Nephropathy
Authors: Piero Ruggenenti, Claudio Flores, Claudio Aros, Bogdan Ene-Iordache, Roberto Trevisan, Cosimo Ottomano, Giuseppe Remuzzi
Journal: Diabetes Care (2003)

OBJECTIVE—To assess whether the insulin analog lispro may antagonize the renal effects of IGF-1, a mediator of glomerular hyperfiltration involved in the progression of diabetic and nondiabetic chronic nephropathies. RESEARCH DESIGN AND METHODS—In a randomized crossover study, we compared the renal and metabolic responses to regular or lispro insulin (0.1 units/kg body wt) administered after a euglycemic clamp and 5 and 30 min before a standard meal to 11 type 2 diabetic patients with macroalbuminuria. RESULTS—Two- and four-hour postprandial changes (vs. preprandial euglycemia) in glomerular filtration rate (GFR) followed a significantly different trend (5.8 ± 5.0 vs. −6.3 ± 4.7, P &amp;lt; 0.05; and 11.0 ± 6.8 vs. 0.7 ± 5.1%, P &amp;lt; 0.05) after regular insulin and lispro injection, respectively. After lispro, postprandial GFR changes were negatively correlated (r = −0.48, P = 0.0001) with plasma insulin concentration. After regular insulin, renal plasma flow increased in parallel with a decrease in renal vascular resistances. Both changes were fully prevented by lispro. Postprandial blood glucose maximum concentration (278 ± 16 vs. 240 ± 16 mg/dl, P &amp;lt; 0.01) and area under the curve (79,381 ± 19,237 vs. 72,810 ± 16,211 mg/dl per min, P &amp;lt; 0,05) were significantly lower after insulin lispro than after regular insulin injection, respectively, despite comparable postprandial insulin profiles. Changes in total and gluconeogenic amino acids followed a similar trend. Changes in blood glucose and plasma amino acids did not correlate with concomitant changes in GFR. CONCLUSIONS—In overt nephropathy of type 2 diabetes, lispro prevents glomerular hyperfiltration and offsets the renal effects of meal or meal-associated hyperglycemia by mechanisms possibly related to IGF-1 antagonism.
Multilineage Potential of Cells From the Artery Wall
Authors: Yin Tintut, Zeni Alfonso, Trishal Saini, Kristen Radcliff, Karol Watson, Kristina Boström, Linda L. Demer
Journal: Circulation (2003)

Background— In diabetes or atherosclerosis, ectopic bone, fat, cartilage, and marrow often develop in arteries. However the mechanism is unknown. We have previously identified a subpopulation of vascular cells (calcifying vascular cells, CVC), derived by dilutional cloning of bovine aortic medial cells, and showed that they undergo osteoblastic differentiation and mineralization. We now show that CVC have the potential to differentiate along other mesenchymal lineages. Methods and Results— To determine the multilineage potential of CVC, molecular and functional markers of multiple mesenchymal lineages were assessed. Chondrogenic potential of CVC was evidenced by expression of types II and IX collagen and cytochemical staining for Alcian blue. Leiomyogenic potential of CVC was evidenced by the expression of smooth muscle-α actin, calponin, caldesmon, and myosin heavy chain. Stromogenic potential of CVC was evidenced by the ability to support growth of colony-forming units of hematopoietic progenitor cells from human CD34 + umbilical cord blood cells for a period of 5 weeks. Adipogenic potential was not observed. CVC were immunopositive to antigens to CD29 and CD44 but not to CD14 or CD45, consistent with other mesenchymal stem cells. CVC retained multipotentiality despite passaging and expansion through more than 20 to 25 population triplings, indicating a capacity for self-renewal. Conclusions— These results suggest that the artery wall contains cells that have the potential for multiple lineages similar to mesenchymal stem cells but with a unique differentiation repertoire.
Ischemic Responses Predictive of Coronary Death
Authors: David H. Spodick
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In my editorial on exercise testing (234:745, 1975), I did not indicate the work of David Scherf, the pioneer whose work not only preceded that of Dr Master, but who also worked out a more scientific work challenge. Dr Scherf introduced the exercise test for the evaluation of carotid disease in 1932. A review of this appeared in<i>Ergebnisse der Gesamten Medizin</i>(20:237, 1935), with later reference in the<i>American Heart Journal</i>(43:927, 1952). I think that recognition is due to this contribution of Dr Scherf, who has already done so much pioneering in the fields of arrhythmias and clinical cardiology.