tbuckley/cabot-search huggingface dataset:
A Nonthrombogenic, Nonanticoagulant-Dependent Mitral Valve Prosthesis
Authors: TREVELYAN E. PALMER, ELIZABETH V. LAUTSCH, MIGUEL E. SANMARCO, JULIO C. DAVILA
Journal: Circulation (1967)

Thromboembolism stems from incompletely covered foreign body which is in physical continuity with tissue. Cardiac valve prostheses which remain partially exposed show, at the tissue-to-prosthesis junction, incomplete healing which is characterized by continuing granulation and proliferating immature unstable scar tissue, from which thrombosis originates and propagates. The principle of complete encapsulation with healthy granulation tissue, maturation into stable fibrous tissue without inflammation, covered by a normal antithrombogenic endothelial surface, is a more logical approach than [see Figure in the PDF file] methods which attempt to prevent thrombosis by altering the character of the surface of the exposed foreign body or the blood coagulation mechanism. A valve is described which functions eminently satisfactorily as a replacement for the calf mitral valve.
Cost-effectiveness and the Management of Pharyngitis-Reply
Authors: Roy M. Poses
Journal: JAMA (1987)

<h3>In Reply.—</h3> Dr Fox correctly points out that the original decision algorithm of Tompkins et al,<sup>1</sup>strictly interpreted, applied to populations with differing rates of throat culture positivity and not to individuals stratified by preculture probability of a positive test. Other work by Tompkins' group,<sup>2</sup>however, applied this algorithm to individual patient care decisions. Also, in their 1977 article,<sup>1</sup>Tompkins et al cited successful efforts to assign individual patients to high and low culture-rate groups and suggested that "use of selected clinical findings may be an appropriate method for clinicians to choose cost-effective treatment for their patients." Thus, even in low-prevalence populations such as ours, there will be patients whose probability of streptococcal disease is sufficiently high to warrant a throat culture, or treatment without prior culture. Regarding Dr Fox' suggestion that testing for antistreptococcal antibodies would have enabled us to detect carriers at low cost, it
Medical Student Transfers
Authors: Kim R. Geisinger
Journal: JAMA (1978)

To the Editor.—  I read with keen interest the timely and poignant article by Charles C. Edwards, MD (239:2463, 1978). I completely agree with him that various agencies of the federal government have confiscated the decision-making process for medical education, and that this is due, in part, to relatively weak professional leadership. I would like to share with the readers ofThe Journala personal experience that emphasized this unfortunate development.  Last year, I began working at the University of Michigan and hoped that my wife, who was a sophomore medical student in an out-of-state medical school, would transfer to this fine institution at that time. After some rather lengthy and vigorous attempts at this transfer, we were informed by the dean's office here that under no circumstances would this medical school accept transfers into the junior year. At least in part, this was based on their claim that there
Velocity field of a Bjork-Shiley valve prosthesis: influence of the disc orientation
Authors: D FARAHIFAR, H BODARD, F CASSOT, R PELISSIER
Journal: Cardiovascular Research (1987)

Journal Article Velocity field of a Björk-Shiley valve prosthesis: influence of the disc orientation Get access D FARAHIFAR, D FARAHIFAR † From the Unité de Cardiologie Expérimentale U–175 INSERM, Marseilles, France Address for correspondence and reprints: Dr D Farahifair. Unité INSERM 210, Faculté de Médecine, Chemin de Vallombrose, 06034 Nice, Cedex, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar H BODARD, H BODARD † From the Unité de Cardiologie Expérimentale U–175 INSERM, Marseilles, France Search for other works by this author on: Oxford Academic PubMed Google Scholar F CASSOT, F CASSOT † From the Unité de Cardiologie Expérimentale U–175 INSERM, Marseilles, France Search for other works by this author on: Oxford Academic PubMed Google Scholar R PELISSIER R PELISSIER ** From the Institut de Mécanique des Fluides, Marseilles, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 2, February 1987, Pages 90–98, https://doi.org/10.1093/cvr/21.2.90 Published: 01 February 1987 Article history Received: 19 November 1985 Accepted: 30 October 1986 Published: 01 February 1987
Coronary Stent Thrombosis in the Current Drug-Eluting Stent Era: Insights From the ERACI III Trial
Authors: Alfredo E. Rodriguez, Juan Mieres, Carlos Fernandez-Pereira, Cesar F. Vigo, Maximo Rodriguez-Alemparte, Daniel Berrocal, Liliana Grinfeld, Igor Palacios
Journal: Journal of the American College of Cardiology (2005)
Genistein Represses Telomerase Activity via Both Transcriptional and Posttranslational Mechanisms in Human Prostate Cancer Cells
Authors: Shankar Jagadeesh, Satoru Kyo, Partha P. Banerjee
Journal: Cancer Research (2006)

Abstract Genistein, the most abundant isoflavone present in soybean has antiproliferative effects on a variety of cancer cells, including prostate cancer. However, the molecular mechanism of antiproliferative effects of genistein is not entirely understood. Because the activation of telomerase is crucial for cells to gain immortality and proliferation ability, we examined the role of genistein in the regulation of telomerase activity in prostate cancer cells. Here, we show that genistein-induced inhibition in cell proliferation is associated with a reduction in telomerase activity. Using reverse transcriptase-PCR and hTERT promoter activity assays, we showed that genistein decreased hTERT expression and transcriptional activity dose-dependently. Using various deleted hTERT promoter constructs, we defined that the hTERT core promoter is enough to observe the genistein-induced repression of hTERT transcriptional activity. Because c-Myc is involved in transcriptional regulation of hTERT, c-Myc expression was examined. A dose-dependent decrease in c-Myc message and proteins was observed with genistein treatment. These results indicate that genistein represses hTERT transcriptional activity via the down-regulation of c-Myc expression. However, genistein-induced repression of hTERT transcriptional activity was not blocked by the mutation of c-Myc at the hTERT promoter, suggesting that additional factors are involved in genistein-dependent repression of telomerase activity. Interestingly, we observed that genistein down-regulates the activation of Akt thereby phosphorylation of hTERT and inhibits its translocation to the nucleus. These results show for the first time that genistein represses telomerase activity in prostate cancer cells not only by repressing hTERT transcriptional activity via c-Myc but also by posttranslational modification of hTERT via Akt. (Cancer Res 2006; 66(4): 2107-15)
MALT lymphoma and Kaposi Sarcoma in an HIV‐negative patient
Authors: Aurora Mirabile, Liliana Devizzi, Alessandro M. Gianni, Antonello Cabras, Antonino Carbone
Journal: American Journal of Hematology (2010)

A 77-year-old caucasian man presented on March 2005 with important epigastric pain without any other significant history of gastritis. Patient refers a history of cutaneous Kaposi's sarcoma (KS) treated since 1974 with surgical excision or oncovorin topical injection. He underwent endoscopic evaluation showing a 1.5-cm ulcerated area at the gastric angulus, associated with edematous and erythematous nodular mucosa (Fig. 1).
Mucocutaneous sarcoidosis treated with mycophenolate mofetil
Authors: D.J. Kouba, D. Mimouni, A. Rencic, C.H. Nousari
Journal: British Journal of Dermatology (2003)

Sir, We appreciate the astute observation of Dr Altschuler in bringing to our attention the article by Kilmartin et al.1 Indeed, we were not aware of their single patient who apparently had sarcoidal uveitis successfully treated with mycophenolate mofetil (MMF) rescue therapy (our Medline search for ‘sarcoidosis’ and ‘mycophenolate mofetil’ did not yield this reference). However, as presented in Table 1 of our original article,2 we document the first description of MMF utilized in the treatment of five patients with histologically proven, refractory cutaneous sarcoidosis, all of whom also had concurrent systemic disease. This unique observation is important for the practising dermatologist treating cutaneous sarcoidosis, as the potential morbidity and mortality of long‐term steroid use may eclipse that of the disease being treated.
Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: A TNF-α/IL-6-dependent mechanism
Authors: Nazia Selzner, Markus Selzner, Yinghua Tian, Zakiyah Kadry, Pierre-Alain Clavien
Journal: Hepatology (2002)

New strategies of partial liver transplantation such as cadaveric split or living related liver transplantation have been developed to overcome organ shortage. Thus, studies on the ability of small partial grafts to regenerate to normal size while maintaining adequate function have become important. Here, we evaluated the effects of cold preservation on hepatocyte proliferation and function in a novel model of partial liver transplantation in rats. Lewis rats subjected to 70% liver resection (control) were compared with rats that underwent total hepatectomy and 30% partial liver transplantation (recipient). Livers were preserved at 4°C for 30 minutes, 10 hours, or 16 hours in University of Wisconsin solution. Seventy percent liver resection was associated with 100% survival, whereas 30-minute, 10-hour, and 16-hour preservation before 30% transplantation resulted in 80%, 40%, and 20% animal survival, respectively. Prolonged time of cold preservation (10 and 16 hours) was associated with a dramatic decrease of all markers of regeneration ( P &lt; .05). Tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) levels were also significantly decreased in recipient rats compared with the control group. Finally, pretreatment of recipients with recombinant IL-6 (rIL-6) normalized all markers of regeneration and significantly improved survival in the 10-hour group (90% vs. 40%; P &lt; .05). In conclusion, sustained periods of cold preservation significantly impaired TNF-α and IL-6 production, the regenerative ability of the liver, and animal survival. rIL-6 reversed impaired regeneration in the 10-hour cold ischemia group and suggests a primary role of nonparenchymal cells in modulating hepatocyte proliferation in the ischemic liver.
Clomiphene Therapy in Hypogonadotrophism with Defective Olfaction
Authors: HOMARD R. NANKIN
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 October 1970Clomiphene Therapy in Hypogonadotrophism with Defective OlfactionHOMARD R. NANKIN, M.D., JAMES B. FIELD, M.D., PHILIP TROEN, M.D.HOMARD R. NANKIN, M.D.Search for more papers by this author, JAMES B. FIELD, M.D.Search for more papers by this author, PHILIP TROEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-4-660 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Clomiphene citrate administered to normal men for 6 days (50 mg every 6 hr) increases circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (1). There was either no change or an inadequate increase in blood levels of gonadotropins when a 6-day course of clomiphene was given to men who had deficient olfactory acuity and hypogonadotrophic hypogonadism (1). Boyar (Ann Intern Med71:1127-1131, 1969) described an anosmic man with hypogonadotrophism who failed to respond to the standard 6-day test, but the continued administration of clomiphene (50 mg/day) for an additional 26 days was associated with an increase of...References1. BARDINROSSRIFKIND CGA: Studies of the pituitary-leydig cell axis in young men with hypogonadotrophic hypogonadism and hyposmia: comparison with normal men, prepuberal boys, and hypopituitary patients. J Clin Invest 48:2046, 1969 CrossrefMedlineGoogle Scholar2. NANKINDRASH HA: Unpublished observations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Pittsburgh School of Medicine Montefiore Hospital and Presbyterian-University Hospital Pittsburgh Pa. 15213 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFunctional MRI of Congenital Hyposmia: Brain Activation to Odors and Imagination of Odors and TastesFAMILIAL KALLMANN'S SYNDROME WITH AUTOSOMAL DOMINANT INHERITANCE, VARIABLE GONADOTROPIN DEFICIENCY AND SUBTLE COLOR VISION DEFECTSHypothalamic and pituitary function in hypogonadotropic hypogonadism8 Endocrine laboratory findings in pubertal disturbancesOlfactory Status and Response to Clomiphene in Male Gonadotrophin DeficiencyCARLOS R. HAMILTON JR., M.D., ROBERT I. HENKIN, M.D., GORDON WEIR, M.D., BERNARD KLIMAN, M.D.Delayed puberty, eroticism, and sense of smell: A psychological study of hypogonadotropinism, osmatic and anosmatic (Kallmann's syndrome) 1 October 1970Volume 73, Issue 4Page: 660-661KeywordsBloodFollicle stimulating hormoneFollicle-stimulating hormoneGonadotropinsHypogonadismLuteinizing hormone ePublished: 1 December 2008 Issue Published: 1 October 1970 PDF downloadLoading ...
Idiopathic Facial Nerve Paralysis and Acute Myocardial Infarction
Authors: W. E. KRAUS
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 August 1986Idiopathic Facial Nerve Paralysis and Acute Myocardial InfarctionW. E. KRAUS, M.D., E. W. MASSEY, M.D.W. E. KRAUS, M.D.Search for more papers by this author, E. W. MASSEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-304_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We write to report three cases of idiopathic peripheral facial nerve paralysis (Bell's palsy) occurring in temporal association with acute myocardial infarction. We calculate the probability of observing three such cases by chance in rapid succession to be small (p < 0.001), and want to draw attention to a potentially important association.Patient 1: A 59-year-old man with hypertension and diabetes mellitus had a subendocardial myocardial infarction. Neurologic findings were normal. Cardiac catheterization, with intravenous streptokinase and percutaneous transluminal coronary angioplasty, was done for evaluation of persistent angina. On the third hospital day, the patient developed paresthesias...References1. PULETTIZINGALESBORGIA MLC. Le complicanze neurologiche nella fase acuta dell' infarto miocardico. G Ital Cardiol. 1981;11:728-35. MedlineGoogle Scholar2. MCALLENMARSHALL PJ. Cerebrovascular incidents after myocardial infarction. J Neurol Neurosurg Psychiatry. 1977;40:951-5. CrossrefMedlineGoogle Scholar3. LAVINWEISSMAN PB. 'Bell's palsy' in accelerated hypertension. Postgrad Med. 1985;77:165-8. CrossrefMedlineGoogle Scholar4. HAUSERKARNESANNISKURLAND WWJL. Incidence and prognosis of Bell's palsy in the population of Rochester, Minnesota. Mayo Clin Proc. 1971;46:258-64. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Duke University Medical Center Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAcute Myocardial Infarction and Facial PalsyJORDI CARRATALA, M.D., XAVIER PINTO, M.D., ANTONI MARTINEZ-AMENOS, M.D., Ph.D. 1 August 1986Volume 105, Issue 2Page: 304-305KeywordsAcute myocardial infarctionAnginaCatheterizationDiabetes mellitusFacial nerveHypertensionMyocardial infarctionParalysisPercutaneous transluminal coronary angioplasty Issue Published: 1 August 1986 PDF DownloadLoading ...
The man did fine, but what about the wahoo?
Authors: J. Hoffman
Journal: JAMA (1992)

<h3>To the Editor.</h3> —An axiom used by the media states that it is news only if "man bites dog." We are presenting a case of "fish bites man," which was given prominent local news coverage. A 69-year-old man was fishing off the Mexican coast of Baja California, when a wahoo, approximately 150 cm long and weighing 22.5 kg, jumped from the water and bit him on his nondominant left upper extremity. The two sites of injury were a superficial laceration to the ulnodorsal border of the hand and a 10-cm laceration to the distal one third of the dorsal forearm. Emergency first aid treatment was given at a Mexican clinic in Baja California, and further treatment was performed at our hospital. At the time of surgery, the tendon of the extensor carpi ulnaris was found to have a 2-cm segmental defect and there was laceration of the extensors of the
MRI-Guided Biopsy of the Prostate Increases Diagnostic Performance in Men with Elevated or Increasing PSA Levels after Previous Negative TRUS Biopsies
Authors: Aristotelis G. Anastasiadis, Matthias P. Lichy, Udo Nagele, Markus A. Kuczyk, Axel S. Merseburger, Joerg Hennenlotter, Stefan Corvin, Karl-Dietrich Sievert, Claus D. Claussen, Arnulf Stenzl, Heinz-Peter Schlemmer
Journal: European Urology (2006)
Risk of Serious Infections and Malignancies With Anti-TNF Antibody Therapy in Rheumatoid Arthritis
Authors: Sarah K. Okada, Jeffrey N. Siegel
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reconstructing microbial communities
Authors: Mihai Pop
Journal: Genome biology (2011)

Deep exome resequencing is a powerful approach for delineating patterns of protein-coding variation among genes, pathways, individuals and populations.We analyzed exome data from 2,440 individuals of European and African ancestry as part of the National Heart, Lung, and Blood Institute's Exome Project, the aim of which is to discover novel genes and mechanisms that contribute to heart, lung and blood disorders.Each exome was sequenced to a mean coverage of 116×, allowing detailed inferences about the population genomic patterns of both common variation and rare coding variation.We identifi ed more than 500,000 single nucleotide variations, the majority of which were novel and rare (76% of variants had a minor allele frequency of less than 0.1%), refl ecting the recent dramatic increase in the size of the human population.The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and purifying selection in shaping patterns of proteincoding variation and the diff erential signatures of population structure from rare and common variation.This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health.
Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer
Authors: Kevin Spring, Farida Ahangari, Shaun P. Scott, Paul Waring, David M. Purdie, Philip C. Chen, Kevin Hourigan, Jonathan Ramsay, Peter J. McKinnon, Michael Swift, Martin F. Lavin
Journal: Nature Genetics (2002)
Abstract P1-12-02: Results of a phase 2, multicenter, single-arm study of eribulin mesylate as first-line therapy for locally recurrent or metastatic HER2-negative breast cancer
Authors: L Vahdat, L Schwartzberg, S Glück, J Rege, J Liao, D Cox, J O'Shaughnessy
Journal: Cancer Research (2012)

Abstract Background: Eribulin mesylate is a novel nontaxane microtubule dynamics inhibitor that is approved in patients (pts) with metastatic breast cancer (MBC) who have previously received at least two chemotherapeutic regimens for MBC. We are reporting a preliminary planned analysis (first 6 cycles of treatment) of a phase 2 study that evaluates efficacy and safety of eribulin as first-line therapy for HER2-negative MBC. Methods: Pts with measureable HER2-negative locally recurrent or MBC with at least 12 months since prior neoadjuvant or adjuvant chemotherapy received eribulin mesylate at 1.4 mg/m2 IV on days 1 and 8 of each 3-week cycle. Endpoints include objective response rate (ORR) (primary), safety, progression free survival (PFS), time to response (TTR), and duration of response (DOR). Tumor assessments were evaluated every 6 weeks for the first 6 cycles and every 6–12 weeks thereafter per RECIST 1.1. Results: 54 of 56 enrolled pts had at least 1 post-baseline assessment. The median number of cycles delivered was 7 (range 1,21). Pt characteristics: median age, 56 yrs (range 31–85); ECOG of 0, 32 (57%); 29% had de novo stage IV; 38/56 (68%) had prior neo/adjuvant (45% had anthracycline and 45% taxane, the majority of which were given together). Seventy percent have visceral disease (45% liver, 38% lung); 41 (73%) have estrogen receptor-positive (ER) disease and 12 (21%) have triple negative (TN) (ER−/PR−/HER2−) disease. Objective response data are found in Table 1. The most common treatment-related AEs are reported in Table 2. Treatment-related serious AEs occurred in 5 (9%) pts, neutropenia (4%), and febrile neutropenia (5%). Five pts stopped study therapy due to adverse events. Fourteen pts remain on study treatment. Conclusions: The preliminary results of this first-line study suggest that eribulin has antitumor activity in ER+/HER2− and TN MBC with an acceptable safety profile. Further exploration of this treatment as part of neo/adjuvant therapy is warranted. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-12-02.