tbuckley/cabot-search huggingface dataset:
Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies
Authors: M Lemaire, M D'Huyvetter, T Lahoutte, E Van Valckenborgh, E Menu, E De Bruyne, P Kronenberger, U Wernery, S Muyldermans, N Devoogdt, K Vanderkerken
Journal: Leukemia (2013)
Papillomavirus invades esophagus, incidence seems to be increasing
Authors: Marsha F. Goldsmith
Journal: JAMA (1984)

Infection of the esophagus by human papillomavirus (HPV)—an agent that some studies have linked to the development of intraepithelial neoplasia and invasive squamous cell carcinoma in other body areas (<i>Cancer Res</i>1979;39:1074-1082,<i>Int J Gynecol Pathol</i>1982; 1:75-94)—was reported for what is believed to be the first time at the recent meeting of the International Academy of Pathology in San Francisco. And, the principal investigator told<i>JAMA</i>MEDICAL NEWS, incidence of the virus, which is acquired either congenitally or through sexual transmission, may be increasing because of an apparent growing prevalence of oral-genital sexual intercourse. The study continues. The investigator, Barbara Winkler, MD, assistant professor of pathology, State University of New York at Stony Brook School of Medicine, told the group that while hyperplastic and papillomatous lesions of the esophagus have been mentioned sporadically in the literature since the early 1920s, the incidence of true squamous papillomas of the esophagus
Authoritarianism as a group-level adaptation in humans
Authors: Sven van de Wetering
Journal: Behavioral and Brain Sciences (1996)

Abstract Wilson &amp; Sober's discussion of group selection is marred by the absence of plausible examples of human group-level behavioral adaptation. The trait of authoritarianism is one possible example of such an adaptation. It reduces within-group variance in reproductive success, manifests itself more strongly in response to group-level threat, and is found in a variety of cultures.
The Surgical Neonate: Evaluation and Care
Authors: Robert J. Touloukian
Journal: JAMA (1986)

<i>The Surgical Neonate</i>, by Filston and Izant, is the second edition of a soft-cover text "written specifically for the pediatric and general surgery house officer rotating through the Pediatric Surgical Service." Divided into the sections "General Management of the Neonate," "Recognition of Major Newborn Congenital Anomalies," and "Management Outline of Common Pediatric Surgical Problems," the book is planned to enable the house officer to recognize the major congenital anomalies and manage affected patients. The initial section is heavily oriented toward parenteral fluid and electrolyte management and the methods for supporting intravenous therapy. The case examples and the practical guidelines used, particularly the "Quadrant Scheme" for estimating third-space losses, have an immediate practical application in writing the postoperative orders. The discussion of total parenteral nutrition could be strengthened by using similar case examples demonstrating the interrelationship of fluid volume, electrolytes, and caloric requirements. An emphasis on peripheral parenteral nutrition vs centrally
NEAR FATAL REACTION TO TRANSFUSION WITH DRIED HUMAN PLASMA SOLUTION
Authors: S. H. Polayes
Journal: JAMA (1942)

The following case is reported in support of our contention that, except in dire emergencies, cross matching tests should be performed with the patient's blood prior to each and every transfusion, whether whole blood or plasma is used. A. N., aged 29, white, a housewife, was admitted in labor to the Prospect Heights Hospital on July 1, 1941. In her early months of pregnancy she had suffered from persistent vomiting, which, however, subsided with the usual therapy. On admission to the hospital she stated that labor had begun at 4 a. m. that day and that the membranes had ruptured two hours later. The essential observations on physical examination were as follows: The patient was in active labor with the fetus in the left occipito-anterior position. The vital signs were normal. There was a functional mitral presystolic murmur. A blood count showed the following: red blood cells 4,340,000 per cubic
The Role of Lysosomes and Proteases in Hormone Secretion and Degradation
Authors: BRUCE S. CHERTOW
Journal: Endocrine Reviews (1981)

In endocrine cells, complex relationships exist between the lysosome and hormone secretion. These relationships may have developed from a common evolutionary origin. As lysosomal and secretory systems evolved, diverse functional relationships developed between them. From a basic intracellular "digestive" role, lysosomes and their proteolytic enzymes developed new and varied origins and functions in hormone processing, release, and intraand extracellular degradation. 1.1 Proteolytic enzymes and hormone availability Hormone effects are a function of the availability of hormone at target receptors. Proteolytic enzymes can have an important role in regulating the availability of hormone by: 1) increasing the intracellular production of secreted forms from precursors, 2) facilitating release or exocytosis, 3) decreasing intracellular concentrations by degradation of excessive intracellular hormone, 4) inactivation or activation of hormone by proteolytic enzymes in serum, and 5) degradation of hormone in target tissues (Table 1). Interrelationships between lysosomal enzymes and secretory pathways are shown in Fig. 1.
Direct current cardioversion. Effect on creatine kinase, lactic dehydrogenase and myocardial isoenzymes
Authors: J. A. Reiffel
Journal: JAMA (1978)

Creatine kinase (CK), lactic dehydrogenase (LDH), and more recently their isoenzyme determinations (CK-MB and LDH1) have been useful adjuncts in verification of myocardial injury. To determine whether DC cardioversion affects these serum enzyme levels, we recorded total CK, total LDH, CK-MB, and LDH1 levels serially during 24 hours following elective DC cardioversion in 18 patients without cardiac ischemia. New postcardioversion elevations in total CK and total LDH levels were small and occasional: CK (one of 18 patients), LDH (four of 18 patients). Elevations of CK-MB or LDH1 following cardioversion did not develop in any of the patients. Therefore, new CK-MB or LDH1 elevations associated with arrhythmias must result from myocardial damage to DC cardioversion.
Functional and Surgical Anatomy of the Hand
Authors: Robert A. Chase
Journal: JAMA (1966)

For those of us who have turned to Emanuel B. Kaplan's<i>Functional and Surgical Anatomy of the Hand</i>as the modern, classical source, the new and expanded edition is a welcome addition to our libraries. The work is scholarly and detailed, reflecting a depth of study and experience that could only be encompassed by someone of Emanuel Kaplan's intellectual tenacity and seniority. There is an expanded section on the interrelationships of intrinsic and extrinsic musculature in coordinate function of the digits which is both concise and clear. The addition of new, cinematographic demonstrations, mechanical analyses, and electromyographic studies has confirmed the contributions of the integrated muscles in this complex organ. Kaplan's zeal in understanding all of kinesiology has bestowed upon us such contributions as his monumental translation of Duchenne's<i>Physiologie des mouvements</i>, many scholarly papers on the hand, the first edition of<i>Functional and Surgical Anatomy of the Hand</i>, and
Abstract LB-34: 3-Dimensional air-liquid interface organoid culture of primary human tumor biopsies
Authors: James T. Neal, Michael Cantrell, Paul Rack, Calvin J. Kuo
Journal: Cancer Research (2014)

Abstract The application of primary organoid cultures to cancer modeling holds promise for combining the accurate multilineage differentiation and physiology of in vivo systems with the facile in vitro manipulation of transformed cell lines. We have previously described a single air-liquid interface culture method that can be used to engineer oncogenic mutations into primary epithelial/mesenchymal organoids from mouse colon, stomach, and pancreas (Ootani et al., Nature Medicine 15(6):701-6 (2009); Li et al., in press). We have recently modified this methodology to allow the robust long-term 3-dimensional culture of a wide variety of primary neoplasms from human biopsy samples. These primary tumor organoids accurately recapitulate the architecture and histopathology of the tumors from which they were derived, including epithelial and mesenchymal compartments. These tumor organoids can be further passaged into 96-well format to enable a variety of genetic and pharmacologic manipulations with the overall goal of enabling mechanistic studies of tumorigenesis and obtaining clinically actionable information regarding chemosensitivity and resistance to therapy. Citation Format: James T. Neal, Michael Cantrell, Paul Rack, Calvin J. Kuo. 3-Dimensional air-liquid interface organoid culture of primary human tumor biopsies. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-34. doi:10.1158/1538-7445.AM2014-LB-34
Architect of DSM-5 rejects claims it will lead to labelling of more people as mentally ill
Authors: I. Torjesen
Journal: BMJ (2013)

The man responsible for the long awaited fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) has rebuffed criticism that the updated manual medicalises everyday life traumas by classifying them as psychiatric conditions and that it would increase the prevalence of certain disorders as a result.

David Kupfer, professor of psychiatry at the University of Pittsburgh and chairman of the DSM-5 task force, said, “The suggestions [have been] that we were medicalising grief, we were increasing the incidence of depression, and that was all for the good of American companies that use medications as their way of making money.”

He added …
Simple precautionary measures can reduce numbers of falls in hospital
Authors: Owen Dyer
Journal: BMJ (2007)

Cyclo-oxygenase-2 (COX 2) inhibitors should be used only as the last choice after other types of non-steroidal anti-inflammatory drugs (NSAIDs) to relieve chronic pain in people with heart disease or at high risk of it, the American Heart Association has recommended.Its statement, published online in Circulation on 26 February (http://circ.ahajournals.orgdoi:10.1161/circulationaha.106.181424), was designed to end any remaining confusion about the cardiovascular risk of these agents.The association has recommended a stepped approach to treatment.The first step should be non-pharmacological approaches, such as physical therapy and weight loss, for patients with known cardiovascular disease or with risk factors for ischaemic heart disease.Drug treatment should start with agents with the lowest reported risk of cardiovascular events, before other agents are prescribed, and at each step account should be taken of the risk-benefit balance.First line drug choices include paracetamol (acetaminophen), aspirin, tramadol, and short term use of other narcotic analgesics.If these fail to achieve adequate pain control, the next option is non-acetylated salicylates, such as naproxen.The association recommended NSAIDs that aren't COX 2 inhibitors if pain is still inadequately controlled, then NSAIDs with some COX 2 activity as the next step, and lastly COX 2 selective NSAIDs.The committee considered the risk of all three of these classes to be sufficiently high to require that patients taking them should be monitored regularly for sustained hypertension (or worsening of prior blood pressure control), oedema, worsening renal function, or gastrointestinal bleeding.See pp 436, 450. Save COX 2 inhibitors till last for cardiac patientsUK NEWS HFEA allows women to donate eggs for research, p445 World NEWS repeal law that puts "FdA on the payroll of the industry", p447 bmj.comUK government defeated on community treatment forms
Medicare Rules &amp; Regulations: A Survival Guide to Policies, Procedures and Payment Reform
Authors: LouAnn Schraffenberger
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes7 September 1999Medicare Rules & Regulations: A Survival Guide to Policies, Procedures and Payment ReformLouAnn Schraffenberger, MBA, RRALouAnn Schraffenberger, MBA, RRAUniversity of Illinois at Chicago School of Biomedical and Health Information Sciences, Chicago, Illinois. (Schraffenberger)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-5-199909070-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Knaus DL. 370 pages. Los Angeles: PMIC; 1998. $49.95. ISBN 1570661243. Order phone 800-633-7467.Field of medicine: Practice management, medical coding and billing, and Medicare.Format: Softcover book.Audience: Physicians, practice managers, financial and business managers, medical coders, and billers.Purpose: To provide physician practices and others with the information they need to bill Medicare Part B for services to Medicare beneficiaries.Content: Ten chapters address Medicare regulations, information on being a participating or nonparticipating physician, and what Medicare generally covers as the primary or secondary payer. A comprehensive chapter on Medicare coding requirements for many types of Medicare Part ... Author, Article, and Disclosure InformationAffiliations: University of Illinois at Chicago School of Biomedical and Health Information Sciences, Chicago, Illinois. (Schraffenberger) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 September 1999Volume 131, Issue 5Page: 400KeywordsHealth careHealth information technologyMedicareSoftware tools Issue Published: 7 September 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Country Doctor's Notebook
Authors: Chris Bird
Journal: BMJ (2007)

In 1916 Mikhail Bulgakov, 24 years old and fresh from medical school in Kiev, was posted to a snowbound rural clinic in northwestern Russia, “thirty-two miles from the nearest electric light,” to fill a gap left by doctors serving on the eastern front. In his semi-fictionalised account, A Country Doctor's Notebook , the young medic spends the journey to the remote hospital on rutted tracks, worrying about how he will cope with tracheotomies and obstructed labour (he has seen only two normal deliveries at medical school), fretting over his youthful appearance, and urging himself to walk, not run.

He doesn't have to wait long …
ONE-YEAR OUTCOMES OF EVEROLIMUS-ELUTING STENTS VERSUS 1ST AND 2ND GENERATION DRUG-ELUTING STENTS FOR THE TREATMENT OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Kyounghoon Lee, Tae Hoon Ahn, Yae-min Park, Kwen-chul Shin, Myeong Gun Kim, Woong Chol Kang, Seung Hwan Han, Eak Kyun Shin
Journal: Journal of the American College of Cardiology (2011)
Final Results of an EORTC-GU Cancers Group Randomized Study of Maintenance Bacillus Calmette-Guérin in Intermediate- and High-risk Ta, T1 Papillary Carcinoma of the Urinary Bladder: One-third Dose Versus Full Dose and 1 Year Versus 3 Years of Maintenance
Authors: Jorg Oddens, Maurizio Brausi, Richard Sylvester, Aldo Bono, Cees van de Beek, George van Andel, Paolo Gontero, Wolfgang Hoeltl, Levent Turkeri, Sandrine Marreaud, Sandra Collette, Willem Oosterlinck
Journal: European Urology (2012)
Sex differences in occupation may affect height associations
Authors: G. Der
Journal: BMJ (2002)

EDITOR—Power et al use data from the national child development study to show that height is related to both social position and social mobility.— They also try to measure the effect of changes in social structure on inequalities in height by comparing two simple summary measures of the relation of height to social class at age 7 (1965) and at age 33 (1991), separately for men and women. They describe the differences in …
Training in paediatrics and child health.
Authors: J K Lloyd
Journal: BMJ (1979)

Reis (24 February, p 559) draws attention to the gross discrepancy in the remuneration accorded to ophthalmic opticians and ophthalmic medical practitioners under the general ophthalmic service.Very politely he regards this state of affairs as a "great peculiarity."Might I suggest that it is more like a scandal.It is true that ophthalmic medical practitioners have very little industrial muscle but this gross discrepancy must cease.Can nothing be done about it ?
Immune Mechanisms in Renal Disease
Authors: William A. Briggs
Journal: JAMA (1983)

This is a very exciting book for graduate and postgraduate students of renal immunology and the pathophysiology of glomerular injury in glomerulonephritis. For this treatise, the editors tapped the expertise of most of the leading investigators in the field of immunologically mediated renal disease, particularly glomerulonephritis and its effects on glomerular structure and function. The result is a handy summary of works from multiple disciplines, which are important to a broad understanding of the immunopathology and pathophysiology of renal disease, but that have not been previously focused within a single reference source.  Despite the complexity of much of the material, the authors and editors succeeded in providing a reference that will be readily readable by persons of varying levels of training and investigative sophistication. The contents of the book are remarkably up to date, considering the rapidity with which this field of knowledge is expanding. The book will represent a
Role of Hormones, Genes, and Environment in Human Cryptorchidism
Authors: Carlo Foresta, Daniela Zuccarello, Andrea Garolla, Alberto Ferlin
Journal: Endocrine Reviews (2008)

Abstract Cryptorchidism is the most frequent congenital birth defect in male children (2–4% in full-term male births), and it has the potential to impact the health of the human male. In fact, although it is often considered a mild malformation, it represents the best-characterized risk factor for reduced fertility and testicular cancer. Furthermore, some reports have highlighted a significant increase in the prevalence of cryptorchidism over the last few decades. Etiology of cryptorchidism remains for the most part unknown, and cryptorchidism itself might be considered a complex disease. Major regulators of testicular descent from intraabdominal location into the bottom of the scrotum are the Leydig-cell-derived hormones testosterone and insulin-like factor 3. Research on possible genetic causes of cryptorchidism has increased recently. Abundant animal evidence supports a genetic cause, whereas the genetic contribution to human cryptorchidism is being elucidated only recently. Mutations in the gene for insulin-like factor 3 and its receptor and in the androgen receptor gene have been recognized as causes of cryptorchidism in some cases, but some chromosomal alterations, above all the Klinefelter syndrome, are also frequently involved. Environmental factors acting as endocrine disruptors of testicular descent might also contribute to the etiology of cryptorchidism and its increased incidence in recent years. Furthermore, polymorphisms in different genes have recently been investigated as contributing risk factors for cryptorchidism, alone or by influencing susceptibility to endocrine disruptors. Obviously, the interaction of environmental and genetic factors is fundamental, and many aspects have been clarified only recently.
Watershed Infarcts, Tc-99m HMPAO SPECT and CT Correlation Case Reports
Authors: TIMOTHY SULLIVAN, JAVIER VILLANUEVA-MEYER, CHING-KUAN LIU, ROBERT GIOMBETTI, ISMAEL MENA
Journal: Clinical Nuclear Medicine (1991)

We report on the use of Tc-99m hexamethylpropylene amineoxime (HMPAO) in watershed infarcts in five patients who had focal neurologic symptoms. Good correlation between Tc-99m HMPAO and CT was found in two patients. In three patients only Tc-99m HMPAO SPECT in a watershed distribution showed a perfusion abnormality that explained the clinical findings. Tc-99m HMPAO SPECT may be more sensitive than CT in the detection of infarctions in the watershed distribution.
Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation
Authors: Sherrie J. Divito, Zhiliang Wang, William J. Shufesky, Quan Liu, Olga A. Tkacheva, Angela Montecalvo, Geza Erdos, Adriana T. Larregina, Adrian E. Morelli
Journal: Blood (2010)
OBESITY IN YOUNG ADULT MEN AND RISK OF TYPE II DIABETES, CARDIOVASCULAR MORBIDITY, OR DEATH BEFORE 55 YEARS OF AGE: A DANISH 33-YEAR FOLLOW-UP STUDY
Authors: Morten Schmidt, Sigrun A. Johannesdottir, Stanley Lemeshow, Timothy Lash, Sinna P. Ulrichsen, Hans Erik Boetker, Henrik Toft Soerensen
Journal: Journal of the American College of Cardiology (2013)
Suicide: Guidelines for Assessment, Management, and Treatment
Authors: L. D. Hankoff
Journal: JAMA (1993)

This multiauthored volume of 16 chapters was designed, according to its editor, "to address the current lacunae in our training efforts in the study of suicide." The work is thus to serve as an introduction and educational text for aspirants in the still evolving field of suicidology. A model training program is offered, and the hope is expressed that a separate professional specialty of suicidology will receive proper recognition. Such a specialty is multidisciplinary and spans many fields of knowledge beyond psychiatry and psychology. The present work makes no effort at a comprehensive review of suicide but rather seeks to point up key issues as a basis for further learning. For example, under the heading "Social Populations" are separate chapters on children, adolescents, and the elderly, and there is no attempt to cover other known high-risk populations such as American Indians. The chapters on treatment focus on the techniques of
The Therapeutic Use of the Sulphites.
Authors: De Pietra Santa
Journal: JAMA (1894)

Paris, Feb. 19, 1894. A M. le RédacteurJournal of the American Medical Associationà Chicago: <h3>Très Honoré Confrère:</h3> Je viens de lire dans votre numéro du 3 févruar une etude très intèressante, du Dr. Joseph Jones sur les<i>sulphites et hyposulphites</i>. M' e' tant moimème beaucoup occupè de le question. Je vous príeraís de vouloir bien faíre parvenir à value collaborateur le Volume "traitement rationnel de la Phthisic Pulmonaíre," qui contient un chapitre important sur le<i>Médication Sulfitée</i>. Cette lecture lui permetra è une prochaine occasion se mentionnen mon nom parmi les partisants de la method. Veullez agreèr avec mes remercíments anticipes l'assurance des mes sentiments très confraternals. [TRANSLATION.] " I read in your number of February 3 a very interesting study by Dr. Joseph Jones, on the sulphites and HYPOsulphites. " I have myself been much occupied with this question. I beg you to bring before your collaborator the book
Management of Dog Bite Wounds
Authors: Michael S. Lehv
Journal: JAMA (1981)

To the Editor.—  I must strongly disagree with Dr Callaham in his article on the treatment of dog bite wounds (1980;244:2327). The author states that all dog bite wounds should be debrided and the edges excised wherever anatomy permits. He further states that this will not only decrease infection but make for  smaller scar and easier repair.  While it may be true that debridement will help to prevent infection in approximately 10% of dog bite wounds, such treatment is probably deleterious in the other 90%. Excision of the edges of an incisional wound will convert it to an elliptic, excisional defect. Linear closure of such a defect must always produce a scar that is longer than the original incisional wound. Furthermore, the tension at right angles to the wound edges must always be greater than that across the original incisional wound. As such, the wound becomes not easier but