tbuckley/cabot-search huggingface dataset:
New Inactivated Polio Vaccine Expected Soon
Authors: Charles Marwick
Journal: JAMA (1990)

A NEW (to the United States at any rate) inactivated poliomyelitis vaccine is likely to become available before the end of the year. If the new inactivated vaccine is licensed, it will become the primary agent for use in those patients in whom live-virus oral polio vaccine is contraindicated or who prefer to be immunized with the inactivated vaccine, replacing the currently licensed, enhanced inactivated polio vaccine made by Connaught Laboratories Inc, Swiftwater, Pa. The two vaccines are similar in safety, immunogenicity, and efficacy. Their great advantage is that there is no incidence of vaccine-associated paralysis as occurs in rare instances with the oral live-virus vaccine. <h3>Cultivated on Different Cells</h3> Indeed, the only real difference between the two vaccines is the cells on which the vaccine virus is cultivated. The currently licensed product is grown on human diploid cells; the new agent is grown on VERO cells, a monkey kidney
India plans joint project with World Bank to improve safe water supply
Authors: S. Bagcchi
Journal: BMJ (2013)

India’s Ministry of Drinking Water and Sanitation has launched a new initiative to provide a safe water supply for drinking, cooking, and other domestic purposes in rural areas of the country.1

A safe water supply in rural areas is an important health related issue in India. WaterAid, an international, non-profit organisation headquartered in the United Kingdom, said, “It is estimated that around 37.7 million Indians are affected by waterborne diseases annually, 1.5 million children are estimated to die of diarrhoea alone and …
SHORT TERM RESULTS OF TRANSCATHETER AORTIC VALVE IMPLANTATION: GLOBAL AND REGIONAL SYSTOLIC LEFT AND RIGHT VENTRICULAR FUNCTION EVALUATED BY ECHOCARDIOGRAPHY EXTENDED WITH TISSUE DOPPLER IMAGING
Authors: Lena M. Helin, éva Tamás, Farkas Vánky, Niels Erik Nielsen, Jan Engvall, Eva Nylander
Journal: Journal of the American College of Cardiology (2010)
Medical Ethics: Supervision of the Ethics of Clinical Investigations in Institutions: Report of R.C.P. Committee
Authors: M. L. Rosenheim
Journal: BMJ (1967)

As for research, the important focus in Britain as in any other country must be on finding why people become addicts and on discovering how they can be aided to recovery: the most profitable focus is likely to be on the society and the person rather than on the drug.Addiction research is nothing special: it is part medical and psychiatric research, and if the experts become isolated.work will suffer.The study of schizophrenia, of the alcoholic, of the recidivist, exploration of the effective elements within psychotherapy, the wide and general field of psychopharmacology-all this is germane.If there is one final lesson to be learnt from all of those who have been grappling with the problem of drug addiction in America for years, it is that discussion in these highly charged and disturbing matters should remain open-that rationality should prevail.This paper is based on the experience of an eight-week trip to the U.S.A. and on discussions held with many people who with the greatest generosity and courtesy gave their time.
Fliegen als ein Befreiungserlebnis
Authors: E. Haisch
Journal: Psychotherapy and Psychosomatics (1955)

Research Articles| January 20 2010 Fliegen als ein Befreiungserlebnis: Eine psychotherapeutische Studie Subject Area: Psychiatry and Psychology E. Haisch E. Haisch Konstanz Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1955) 3 (3): 251–258. https://doi.org/10.1159/000278490 Article history Published Online: January 20 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation E. Haisch; Fliegen als ein Befreiungserlebnis: Eine psychotherapeutische Studie. Acta Psychotherapeutica et Psychosomatica 1 March 1955; 3 (3): 251–258. https://doi.org/10.1159/000278490 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1955Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Large Intravenous Dosage of Thiamine
Authors: N.T. Pollitt
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I have read with considerable interest Dr. Haunz's answer to "MD, Florida" [<b>201</b>:901, 1967] but am rather concerned that large intravenous doses of thiamine hydrochloride, ie, 100 mg daily for seven days, are recommended. Doses of this vitamin<i>given on its own</i>are liable to induce anaphylactoid reactions, and there are at least six fatal cases published in the world literature. However, from experience in the United Kingdom, when such large doses of thiamine hydrochloride are given intravenously<i>with other members of the B complex</i>(eg, in the treatment of certain psychiatric emergencies) the risk of such reactions is negligible. I would agree with your contributor that prolonged thiamine deficiency could be a possible reason for apparent carbohydrate dyspepsia, but I would like to suggest, with respect, that estimation of erythrocyte transketolase activity inThe Journal(<b>187</b>:762, 1967) is a more specific indicator of thiamine
Blood Pressure Measurement in Childhood Epidemiological Studies
Authors: Matthew W. Gillman, Nancy R. Cook
Journal: Circulation (1995)

Background Accurate measurement of blood pressure in childhood epidemiological studies requires standardized conditions, valid instruments, and multiple measurements. Methods and Results We used published literature and our own data to make recommendations on the reduction of biases caused by various technical factors, to discuss the advantages and disadvantages of selected measurement devices, and to evaluate the optimal number of visits and measurements per visit for accurate estimation of a child’s blood pressure level. The conditions under which blood pressure is measured should be standardized. This includes training and certification to minimize observer biases; equipment factors such as use of an appropriate cuff bladder size, subject factors such as minimizing activities before and during the reading, environmental factors such as accounting for the time of day and ambient temperature, and technique factors such as recording both the fourth and fifth Korotkoff sounds. The choice of instrument for measuring blood pressure depends on the goals of the study and the resources available to the investigators. Conclusions Although relatively economical and easy to use, the standard mercury sphygmomanometer is subject to the bias resulting from knowledge of earlier readings. The random-zero sphygmomanometer overcomes this bias, but it is more expensive and difficult to use and may underestimate blood pressure levels. In contrast to auscultatory devices, automated oscillometric devices are not subject to observer biases. They are gaining wider use and may be especially appropriate for younger children. However, they are expensive, and each model requires validation before use in epidemiological studies. Ambulatory blood pressure monitoring represents a potentially useful technique for future epidemiological studies. Multiple measurements are vital in estimating a child’s blood pressure, and the number of visits, days or weeks apart, is at least as important as the number of measurements per visit.
Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998)
Authors: T P Loughran, L Zickl, T L Olson, V Wang, D Zhang, H L M Rajala, Z Hasanali, J M Bennett, H M Lazarus, M R Litzow, A M Evens, S Mustjoki, M S Tallman
Journal: Leukemia (2014)
Long-term administration of a sucrose-rich diet to normal rats: Relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreas
Authors: Y.B. Lombardo, S. Drago, A. Chicco, P. Fainstein-Day, R. Gutman, J.J. Gagliardino, C.L. Gomez Dumm
Journal: Metabolism (1996)
Perinatal Infectious Diseases
Authors: Leslie L. Barton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GP based primary care is only just starting to emerge in China
Authors: J. Parry
Journal: BMJ (2010)

If China used GPs instead of hospitals to deliver primary health care, one in five deaths that are due to preventable risk factors could potentially be averted, say researchers at the University of Sydney. 

Such a system would also help to get the best results from China’s ¥850bn (£81bn; €98bn; $125bn) health reform package now under way, but there are few signs that the idea is being embraced, observers say.

Hypertension accounts for 11.7% of deaths in China, while smoking and physical inactivity account for 7.9% and 6.8%, respectively. “Primary care is better placed than large hospitals to monitor risk factors such as high blood pressure, smoking, diet, exercise, and other lifestyle changes,” said Lyndal Trevena, head of the Office for Global Health at Sydney Medical School. “Many of the most effective strategies to address these risk factors can be implemented in primary …
SC-18 * DOES INVOLVEMENT OF THE NEURAL STEM CELL COMPARTMENT INFLUENCE OUTCOMES IN ADULT LOW GRADE GLIOMAS? A RETROSPECTIVE REVIEW OF 95 CASES
Authors: J. Marsh, G. Ziel, A. Diaz, R. Byrne
Journal: Neuro-Oncology (2014)

PURPOSE: To assess the rate of neural stem cell compartment (NSC) involvement in World Health Organization (WHO) grade II gliomas treated at our institution, and whether involvement of NSC at presentation influenced outcomes. METHODS AND MATERIALS: 95 cases were reviewed. Rates of NSC involvement were assessed at presentation and (where applicable) recurrence and/or transformation. We further assessed whether NSC involvement influenced overall survival (OS), rate of recurrence (RR), rate of transformation (RT) to high grade glioma (HGG, WHO grade 3-4), time to recurrence (TTR), overall survival from time of recurrence (OSR), and overall survival from time of transformation (OST). Mean outcomes were compared using paired student t test, whereas incident rates were compared using Fisher's Exact Test. RESULTS: Mean duration of follow up was 48.6 months (60.8 months for survivors). NSC was involved in 77/95 cases (81.1%).20/25 recurrent tumors involved NSC (80%), and 20/22 transformed cases involved NSC (90.9%). 22/25 recurrent tumors had transformed to HGG (88%), and 19/22 recurrent HGG involved NSC (86.4%). There were trends toward worse mean OS for NSC+ patients: all cases (46.3 vs. 57.7 mos., p.31), recurrent cases (61 vs. 81.3 mos., p.25), and transformed cases (61.7 vs. 92 mos., p.36). There was shorter mean TTR (37.2 vs. 52.2 mos., p.54), OSR (29.6 vs. 41.2 mos., p.52), and OST (30.1 vs. 50.3 mos., p.52) in NSC+ patients, but differences were not statistically significant. CONCLUSIONS: We found high rates of NSC involvement in our adult WHO grade II glioma patients at presentation, and also at the time of recurrence and/or transformation to high grade disease. We identified a trend toward worse outcomes in tumors involving NSC, but differences did not reach statistical significance, possibly due to our limited number of patients. Involvement of NSC at presentation does not appear to influence rates of recurrence.
Predictors of group 5 grass‐pollen allergens in settled house dust: comparison between pollination and nonpollination seasons
Authors: B. Fahlbusch, D. Hornung, J. Heinrich, L. Jäger
Journal: Allergy (2001)

Background: Some sensitive pollen‐allergic patients may experience perennial symptoms, and for these patients it is vitally important to know the concentration of grass‐pollen allergens in their homes. The main objective of this study was to detect predictors associated with high grass allergen concentration in settled house dust during and outside the grass pollination season. Methods: We detected group 5 grass‐pollen allergens in dust samples from randomly selected homes of three counties in the region of Sachsen‐Anhalt: Hettstedt ( n =183), Zerbst ( n =152), and Bitterfeld ( n =119). Dust samples were collected from the floors of living rooms (LR) and children's rooms (CR) from April 1996 to March 1998. Results: Phl p 5 was detected in settled house dust in 91% of the homes. The range was between undetectable (&lt;30 ng/m 2 ) and 4300 ng Phl p 5/m 2 sampling area during grass pollination, and 1300 ng Phl p 5/m 2 outside the pollination season, respectively. We observed a partially higher concentration of indoor allergenic activity several weeks after the grass‐pollen peak. A positive association was found between Phl p 5 levels and total dust amounts throughout the year. Thus, we assume that grass allergens accumulate in settled house dust. During pollination, the Phl p 5 levels are 1.8 times higher in homes where vacuuming of carpets takes place only once a week or less than in those vacuumed daily. Furthermore, higher concentrations of Phl p 5 in settled floor dust can be expected in homes located within suburban areas (mean ratio [MR] 1.74) and prefabricated slab buildings (MR=1.54). Conclusions: Quite high levels of Phl p 5 accumulate in settled house dust even during periods when no grass pollen is present in the atmosphere. The removal of dust by frequent cleaning reduces the indoor exposure to grass allergens. Such information is essential to train patients in allergen avoidance.
THE HEMAGGLUTINATING FRACTION OF HUMAN SERUMS
Authors: RUFUS L. HOLT
Journal: JAMA (1922)

The chronic roentgen dermatitis belongs to the affec¬ tions in which the prophylaxis means all and therapy nothing."SUMMARY 1.A roentgen toxemia appears insidiously, but nev¬ ertheless-may cause serious disturbances and even roentgen cachexia.To avoid it, the roentgen technic ought to be accommodated to the general condition of the patient.2. A renal function test should be made before irradiation.3. Plenty of water by mouth, proctoclysis, hypo- dermoclysis, mild cathartics, diuretics and blood trans¬ fusion eventually, preceded by venesection, help to dilute and eliminate the toxic material.4. Irritating drugs should not be applied to the skin for three weeks after irradiation.
Tuberculous meningitis and resistance to isoniazid
Authors: B. Blomberg, N. Langeland
Journal: BMJ (2010)

Higher case fatality rate should prompt prudent use of antituberculous drugs

In the linked study (doi:10.1136/bmj.c4451), Vinnard and colleagues assess whether initial resistance to isoniazid is associated with death during the treatment of tuberculous meningitis.1 Central nervous system tuberculosis accounts for about 1% of the estimated 9.4 million annual cases of tuberculosis worldwide.2 Tuberculous meningitis is a medical emergency and in the past was usually lethal, although better chemotherapy, starting with streptomycin in 1947, has improved survival dramatically.3 Nonetheless, even with modern treatment almost a third of patients die, and case fatality rate approaches two thirds in patients with HIV.4 Half of those who survive have neurological sequelae.5

Because delayed treatment increases case fatality rate,6 it is unfortunate that tuberculous meningitis is so difficult to diagnose. In high income countries, patients may die because of the delay in diagnosis—culture of Mycobacterium tuberculosis requires special medium and takes many weeks. In developing countries, clinicians make a presumptive diagnosis by combining clinical data and simple laboratory results,7 but they struggle to confirm the diagnosis …
Monoallelic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia
Authors: P Van Vlierberghe, H B Beverloo, J Buijs-Gladdines, E R van Wering, M Horstmann, R Pieters, J P P Meijerink
Journal: Leukemia (2007)
SPOROTRICHOSIS
Authors: GEORGE M. LEWIS
Journal: Annals of Internal Medicine (1934)

Article1 February 1934SPOROTRICHOSISREPORT OF A CASE ORIGINATING IN NEW YORK *GEORGE M. LEWIS, M.D., J. HOMER CUDMORE, M.D., F.A.C.P.GEORGE M. LEWIS, M.D.Search for more papers by this author, J. HOMER CUDMORE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-8-991 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a recent publication, Hopkins and Benham1reviewed the incidence of sporotrichosis in New York State, and found that only one culturally proved case had been reported previous to their communication. The first case was presented by Howard Fox2before the New York Academy of Medicine in 1921. The patient was a sailor and probably acquired the disease in the tropics. The two cases reported by Hopkins and Benham1included one observed by Osborne in Buffalo in 1928, and one studied by them in New York City in 1929. The second case probably developed the infection in Monticello, New York....Bibliography1. HOPKINSBENHAM JGRW: Sporotrichosis in New York State, New York State Jr. Med., 1932, xxxii, 595-601. Google Scholar2. FOX H: Case presentation, Arch. Dermat. and Syph., 1932, v, 531. Google Scholar3. TURRELL GH: Sporotrichosis, Long Island Med. Jr., 1911, v, 484-488. Google Scholar4. LAPOWSKY B: Sporotrichosis, Jr. Cutan. Dis., 1919, xxxvii, 281. Google Scholar5. WISE F: Case presentation, Arch. Dermat. and Syph., 1921, iv, 268. Google Scholar6. WALZER A: Case presentation, Arch. Dermat. and Syph., 1931, xxiii, 349. Google Scholar7. MOUNT LB: Sporotrichosis, with report of a rather unusual case, Arch. Dermat. and Syph., 1932, xxv, 528-534. CrossrefGoogle Scholar8. LAWLESS TK: The diagnosis of sporotrichosis, Arch. Dermat. and Syph., 1930, xxii, 381-388. CrossrefGoogle Scholar9. FOERSTER HR: Sporotrichosis, an occupational dermatosis, Jr. Am. Med. Assoc., 1926, lxxxvii, 1605-1609. CrossrefGoogle Scholar10. BENHAMKESTEN RWB: Sporotrichosis; its transmission to plants and animals, Jr. Infect. Dis., 1932, i, 437-458. CrossrefGoogle Scholar11. JACOBSON HP: Fungous diseases: a clinico-mycological text, 1932, Chas. C. Thomas, Springfield, Illinois, p. 132. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE M. LEWIS, M.D.; J. HOMER CUDMORE, M.D., F.A.C.P.Affiliations: New York, N. Y.*Received for publication August 4, 1933.From the Department of Dermatology and Syphilology, New York Post-Graduate Medical School and Hospital, Columbia University, Dr. George M. MacKee, Director; and the Manhattan General Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExperimental sporotrichosis in Syrian hamstersSporotrichosis 1 February 1934Volume 7, Issue 8Page: 991-999KeywordsArmed forcesDermatologySporotrichosis ePublished: 1 December 2008 Issue Published: 1 February 1934 PDF downloadLoading ...
The Non‐Specific Enhancement of Allergy
Authors: Magnus Dahlbäck, Håkan Bergstrand, Romain Pauwels, Herve Bazin
Journal: Allergy (1983)

SD rats were sensitized by an i.p. injection of 1 μg or 10 μg ovalbumin (OA) together with 10 mg Silica gel. At the indicated time alter sensitization, allergic response capacity of the animals was estimated by measuring changes in intratracheal pressure induced by an i.v. injection of 0.3 mg OA (low challenge dose) or 5 mg OA (high challenge dose). Animals given 1 μg OA in Silica gel showed no response capacity at 14, 35 or 47–48 days after sensitization. Animals injected with 10 μg OA showed a clear‐cut response with a peak at 14 days; at 7 weeks after immunization the response capacity had faded almost completely. Specific OA‐IgE antibody and total IgE serum levels were examined by radioimmunoassay, A slight increase in OA‐IgE antibody was recorded in animals in injected 14 days before test with 10 μg ovalbumin and Silica gel; animals given 1 μg OA and Silica showed no OA‐IgE antibody. Five weeks after sensitization, some animals of each group were injected i.p. with 100 mg alum, B. pertussis vaccine (2 ml of Perthydral®), or saline, all injections being made without any further antigen addition. 12–13 days after such an injection, alum‐treated animals showed high response capacity at bronchial anaphylatic tests and high OA‐IgE antibody levels but comparably low levels of total IgE. Animals injected with B. pertussis , on the other hand, showed high response capacity at bronchial anaphylactic tests and OA‐IgE antibody levels) but high total IgE‐antibody levels. The bronchial anaphylactic response in the B. Pertussis ‐injected animals but not the alum‐injected animals was significantly correlated to serum IgG 2a antibody levels. These results show that injection of alum or B. pertussis vaccine without antigen can precipitate/enhance anaphylactic response capacity and production of specific and nonspecific IgE and IgG 2a .