tbuckley/cabot-search huggingface dataset:
A COMPARISON OF ANTISEPTIC AND NON-ANTISEPTIC METHODS IN SURGERY.
Authors: DUDLEY P. ALLEN
Journal: JAMA (1883)

continued to drink spirits more or less freely.The subsequent history is not noted.Case X.-Ascites referable to thrombosis of portal vein.Tapping ten times within three months.No return of the dropsy, and the patient in fair health eleven years afterward.Diet of milk and ginger¬ bread.This patient, a man 45 years of age, of good habits, came under my observation, in private prac¬ tice, eleven years ago.He had been ill for several weeks, his symptoms having been supposed to denote thrombosis of the portal vein.I may mention that the patient's wife, a very intelligent woman, had en¬ deavored to s'tudy her husband's case by reading medical books, and the reason of my being called in consultation was the advocacy of tapping in my notes on the Practice of Medicine.The abdomen was greatly distended.Owing to the feebleness of the patient, it had been deemed hazardous to resort to tapping.This measure, however, at my sugges¬ tion, was at once employed, and notable, immediate relief followed.Within three months the patient was tapped ten times, The aggregate amount of liquid removed was about 350 pounds.After the last tapping there was only a moderate accumulation of liquid, and this gradually disappeared.The patient slowly recovered, and for the past ten years he has had fair health.His aspect is healthy, and he is accustomed to walk from four to six miles daily.During the period when the tappings were repeat¬ ed, and for more than a year afterward, this patient confined his diet strictly to milk and gingerbread.These articles have constituted the greater part of his diet ever since.He has taken neither fish nor fowl nor meat of any kind.He is accustomed to take, in addition to the milk and gingerbread, rice, oys¬ ters, eggs and asparagus.On one occasion he was led to indulge for several days in the luxury of eating boiled green Indian corn.This was followed by a moderate return of the ascites, which disappeared un¬ der the use of diuretics.After this experience he resolved to stick to the diet to which he had become habituated.Case XL.-Case of supposedportal'thrombosis. Tap¬ ping repeated ten times.Complete recovery.This patient, a man aged 47, came under my ob¬ servation in private practice, in March, 1880.His illness began in December, 1880.He was then in Kansas.He was there considered to have malarial fever and inflammation of the liver and spleen.Between December 8 and 27 he had three attacks of naematemesis and became greatly prostrated.Following this, ascites developed, and oedema of the lower limbs.On February 3, 1881, he was.tapped for the first time, and twenty quarts of liquid re¬ moved.He was again tapped February 17, and March 2.He was then brought to Hoboken, N. J., and was seen by me, in consultation with Dr. T. R. Varick, of Jersey City.
The Risk of Ectopic Pregnancy after Tubal Sterilization
Authors: Herbert B. Peterson, Zhisen Xia, Joyce M. Hughes, Lynne S. Wilcox, Lisa Ratliff Tylor, James Trussell
Journal: New England Journal of Medicine (1997)

Tubal sterilization is an increasingly common method of contraception in the United States. Although pregnancy after sterilization is uncommon, it can occur and may be ectopic. We used data from the U.S. Collaborative Review of Sterilization to estimate the risk of ectopic pregnancy in women who had undergone the common types of tubal sterilization.
Review of David H. Brendel,<i>Healing Psychiatry—Bridging the Science/Humanism Divide</i><sup>1</sup>
Authors: Nada Gligorov
Journal: The American Journal of Bioethics (2007)

"Review of David H. Brendel, Healing Psychiatry—Bridging the Science/Humanism Divide 1 ." , 7(11), pp. 52–53 Notes 1.Cambridge, MA: MIT Press, 2006. 178 pp. $26.00, hardcover.
Heparan Sulfate Proteoglycans Mediate a Potent Inhibitory Signal for Migration of Vascular Smooth Muscle Cells
Authors: Noriyuki Koyama, Michael G. Kinsella, Thomas N. Wight, Ulf Hedin, Alexander W. Clowes
Journal: Circulation Research (1998)

Migration of vascular smooth muscle cells (SMCs) is a key step in vascular remodeling and formation of pathological lesions in diseased arteries and may be controlled by extracellular matrix (ECM) and by factors that regulate ECM composition, such as platelet-derived growth factor (PDGF). In culture, PDGF-AB and -BB enhance but PDGF-AA (although having no effect alone) suppresses SMC migration stimulated by other PDGF isoforms. To determine whether the migration-inhibitory mechanism of PDGF-AA was mediated by ECM composition, we examined baboon SMC migration in a Boyden chamber assay using filters coated with different ECM proteins. PDGF-AA suppressed the PDGF-BB-induced migration of baboon SMCs on a filter coated with basement membrane proteins (Matrigel) and fibronectin but failed to inhibit cell migration on a type I collagen (Vitrogen)-coated filter. Fibronectin and fibronectin fragments that contain heparin-binding domains permitted PDGF-AA inhibition of cell migration, but a fragment lacking heparin-binding domains did not. Treatment of SMCs with heparin lyases II and III, but not with chondroitin ABC lyase, diminished the PDGF-AA-mediated inhibition of migration. PDGF-AA stimulated accumulation of proteoglycan (PG) in the cell layer more potently than did PDGF-BB, whereas the turnover of cell layer PG was unaffected by either PDGF-AA or -BB. Northern blot analysis revealed that PDGF-AA increased syndecan-1 mRNA expression more than did PDGF-BB, whereas both PDGF isoforms decreased perlecan expression. The changes in cell migration and PG synthesis induced by PDGF-AA were accompanied by changes in the morphology of SMCs. PDGF-AA dramatically induced the spreading of SMCs, whereas the heparin lyase treatment of PDGF-AA-stimulated cultures diminished cell spreading. The data suggest that PDGF-AA selectively modifies heparan sulfate PG accumulation on SMCs and thereby influences the interactions of SMCs with heparin-binding ECM proteins. These interactions, in turn, generate signals that suppress SMC migration.
Long term prognosis of children born to lupus patients
Authors: A Murashima
Journal: Annals of the Rheumatic Diseases (2003)

To determine the long term prognosis of children of patients with systemic lupus erythematosus (SLE).Children of patients with SLE were invited to attend our clinic for physical examination and laboratory tests. A total of 195 children (aged 4 months to 26 years; male = 82, female = 113) were examined in 1991, 1995, 1997, and 1998.Two cases were diagnosed as SLE at the first visit and were excluded from the second visit. A significantly higher percentage (52/195 (27%)) of patients were positive for antinuclear antibodies (ANA) at a cut off serum dilution of 1/40 compared with controls (4/57 (7%)). ANA were detected more frequently in female subjects than in men (p<0.05). Forty four subjects were examined on more than two occasions. Nine of the 10 patients who were positive for ANA at the second visit were girls aged 4-8 years. The incidence of anti-DNA and antiphospholipid antibodies in children of patients with SLE was similar to that in the controls.The finding that children, especially girls, born to maternal lupus patients had a high positive rate for ANA suggests that a genetic factor is involved in SLE pathogenesis. Longitudinal observation of these patients may provide important clinical information and clues to the pathogenesis of SLE.
Abstract C51: c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion, proliferation, survival, and drive metastatic progression
Authors: Sourik S. Ganguly, Leann S. Fiore, Jonathan T. Sims, J Woodrow Friend, DivyaMani Srinivasan, Matthew Thacker, Michael L. Cibull, Wang Chi, Rina Plattner
Journal: Cancer Research (2013)

Abstract Despite 40 years of clinical trials, there has been little improvement in one-year survival rates for patients with metastatic melanoma, and the disease is essentially untreatable if not cured surgically. The paucity of chemotherapeutic agents that are effective for treating metastatic melanoma indicates a dire need to develop new therapies. Here, we found a previously unrecognized role for Abl kinases in melanoma progression. We demonstrate that Abl kinases (c-Abl, Arg) are activated in human melanoma cell lines, in primary melanomas (60%), and in a subset of benign nevi (33%). Using siRNA and pharmacological approaches, we show that c-Abl/Arg activation is functionally relevant because it is required for melanoma cell proliferation, survival, matrigel-invasion and single-cell 3D invasion. Moreover, active c-Abl transcriptionally upregulates MMP-1, and using rescue approaches we show that c-Abl promotes invasion via a STAT3-MMP-1 pathway. Conversely, active Arg drives invasion in a STAT3-independent manner, and upregulates MMP-3 and MT1-MMP, in addition to MMP-1. Paradoxically, c-Abl and Arg also increase expression of TIMP-1, a negative regulator of MMPs, both at the transcript and protein level via a STAT3-dependent pathway. In addition to negatively regulating MMPs, TIMPs also have anti-apoptotic functions, and high TIMP-1 expression is correlated with decreased survival and a poor clinical outcome in breast and colon cancer patients. Currently, we are in the process of testing whether c-Abl and Arg promote survival via induction of TIMP-1. Most importantly, we found that Abl kinases not only promote in vitro processes important for melanoma progression, but also promote metastasis in vivo, as inhibition of c-Abl/Arg with nilotinib dramatically inhibits lung colonization/metastasis in a mouse model using two different melanoma cell lines. Taken together, these data identify Abl kinases as critical, novel, drug targets in metastatic melanoma, and indicate that nilotinib may useful in preventing metastasis in patients with melanomas harboring active Abl kinases. Citation Format: Sourik S. Ganguly, Leann S. Fiore, Jonathan T. Sims, J Woodrow Friend, DivyaMani Srinivasan, Matthew Thacker, Michael L. Cibull, Wang Chi, Rina Plattner. c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion, proliferation, survival, and drive metastatic progression. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr C51.
A novel mutation of the protein C gene with a frameshift deletion of 3 base pair F (3380AGG) in exon 6 in type 1 deficiency associated with arterial and venous thrombosis
Authors: Toru Takahashi, Kenji Shinohara, Ryohei Nawata, Machiko Wakiyama, Naotaka Hamasaki
Journal: American Journal of Hematology (1999)

Forming Assay From CD34 + Bone Marrow Cells Serum a BFU-E/10 2 CD34 + cells Control 1 50.2 ± 4.6 Control 2 48.5 ± 14.1 Before chemotherapy 24.4 ± 6.2 b After chemotherapy 50.5 ± 6.5 Values are means ± SD of triplicate cultures.a Control 1; normal AB serum, Control 2; serum from a patient with AILD-T without PRCA.b Significantly decreased compare with controls (P < 0.05).
Decreased Pulmonary and Tracheal Smooth Muscle Expression and Activity of Type 1 Nitric Oxide Synthase (nNOS) after Ovalbumin Immunization and Multiple Aerosol Challenge in Guinea Pigs
Authors: ABDOULAYE SAMB, MARINA PRETOLANI, ANH-TUAN DINH-XUAN, HAKIMA OUKSEL, JACQUES CALLEBERT, CONSTANZA LISDERO, MICHEL AUBIER, JORGE BOCZKOWSKI
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Pharmacological evidence supports a role of a transient decreased endogenous nitric oxide (NO) synthesis in ovalbumin (OVA)-induced early airway hyperresponsiveness in guinea pigs. However, no data are available regarding the expression and activity of the constitutive NO synthases (cNOS; NOS1 and NOS3, nNOS and eNOS, respectively) in this model. Therefore, we evaluated cNOS activity (conversion of L-[3H]arginine to L-[3H]citrulline in the presence of Ca2+ and calmodulin), nitrate and nitrite (NOx) concentration (modified Griess method), and NOS1 and NOS3 protein expression (Western blot) in lung homogenates and in the tracheal smooth muscle from OVA-immunized and multiple aerosol-challenged guinea pigs (six challenges, once daily). The expression and activity of the inducible NOS isoform (NOS2), the levels of exhaled NO, and the in vivo airway reactivity were also determined. Constitutive NOS activity and NO(x) concentration were significantly lower 6 h after the last OVA challenge as compared with saline exposure, being similar at 24 h. Expression of NOS1 paralleled cNOS activity, which was reduced 6, but not 24 h after OVA challenge. The decrease in NOS1 expression was accompanied by a significant decrease in the amounts of exhaled NO and by a maximal airway hyperresponsiveness to histamine. The levels of NOS3 were not modified at the two time points evaluated, and no NOS2 expression and activity were found at any time point. Similar modifications were observed in the tracheal smooth muscle. We conclude that OVA stimulation in immunized guinea pigs induced a transient reduction in NOS1 protein expression and activity in the respiratory system, which probably participates in airway hyperresponsiveness.
THE TREATMENT OF SYCOSIS BARBAE, WITH SPECIAL REFERENCE TO RELAPSES
Authors: BRIAN RUSSELL
Journal: British Journal of Dermatology (1947)

Journal Article THE TREATMENT OF SYCOSIS BARBAE, WITH SPECIAL REFERENCE TO RELAPSES Get access BRIAN RUSSELL, M.D., M.R.C.P BRIAN RUSSELL, M.D., M.R.C.P Skin Department, London Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 59, Issue 8-9, 1 August 1947, Pages 294–300, https://doi.org/10.1111/j.1365-2133.1947.tb10909.x Published: 01 August 1947
1050. Mouse Embryonic Endothelial Progenitor Cells Home to Atherosclerotic Lesions after Intravenous Delivery
Authors: Ba-bie Teng, Eva Zsigmond, Kathyjo Jackson
Journal: Molecular Therapy (2006)

The integrity of the endothelial monolayer plays a critical role in preventing the pathogenesis of atherosclerosis. This study was designed to investigate whether mouse embryonic endothelial progenitor cells (eEPCs) participate in endothelial repair and limit atherosclerotic lesion formation.
TRPC channels, an overarching Ca2+ paradigm in the developing heart
Authors: Y. Qu, M. Boutjdir
Journal: Cardiovascular Research (2011)

This editorial refers to ‘A key role of TRPC channels in the regulation of electromechanical activity of the developing heart’ by J. Sabourin et al. , pp. 226–236, this issue .

It is well established that in the adult mammalian heart, small amounts of Ca2+ entry via voltage-dependent sarcolemmal Cav1.2 L-type Ca2+ channels can trigger the release of a significant amount of Ca2+ from the sarcoplasmic reticulum (SR) that is followed by muscle contraction, a process known as excitation–contraction (EC) coupling.1 However, for the developing mammalian and avian hearts, earlier studies proposed that EC coupling relies essentially on transsarcolemmal influx of Ca2+ through L-type Ca2+ channels, mainly Cav1.2, and that the contribution of the SR is minimal.2 In the embryonic chick heart, Ca2+ channel density is maximal at 3 days and decreases at 17 days,3 whereas Ca2+ channel density is low in the foetal heart and increases with development in guinea-pig,4 rabbit,5 and human,6 consistent with the need for additional Ca2+ entry through other sarcolemmal voltage-dependent proteins such as the T-type Ca2+ channel, the Cav1.3 L-type Ca2+ channel, and the Na/Ca2+ exchanger (NCX).2,6–8 Other candidate channels …
Pleasure and Quality of Life
Authors: I. Robertson
Journal: BMJ (1996)

Ed D M Warburton, N Sherwood John Wiley, £39.95, pp 326 ISBN 0471 96511 1

Did you read the title of this book? Please read it again. Now put the BMJ down and spend 30 seconds thinking what it might be about: Family? Sorry, no. Friendship? Er, not this time. Sex? Definitely not. Music? No way. Wealth and poverty? Nope. Sport, recreation, or hobbies? No. Housing and availability of health care? Ditto. Participation in the arts? Not quite. The effects of pain and chronic disability on the quality of people's lives? Come on! Get relevant! Stop asking all these silly questions and get to …
Measurement issues in environmental epidemiology.
Authors: M Hatch, D Thomas
Journal: Environmental Health Perspectives (1993)

This paper deals with the area of environmental epidemiology involving measurement of exposure and dose, health outcomes, and important confounding and modifying variables (including genotype and psychosocial factors). Using examples, we illustrate strategies for increasing the accuracy of exposure and dose measurement that include dosimetry algorithms, pharmacokinetic models, biologic markers, and use of multiple measures. Some limitations of these methods are described and suggestions are made about where formal evaluation might be helpful. We go on to discuss methods for assessing the inaccuracies in exposure or dose measurements, including sensitivity analysis and validation studies. In relation to measurement of health outcomes, we discuss some definitional issues and cover, among other topics, biologic effect markers and other early indicators of disease. Because measurement error in covariates is also important, we consider the problems in measurement of common confounders and effect modifiers. Finally, we cite some general methodologic research needs.
Epidermoid Cyst of Cecum
Authors: N. Candreviotis
Journal: JAMA (1965)

To the Editor:—  Recently I have had the opportunity to observe the third reported case of epidermoid cyst in the cecum. Only two other references were found in the literature. 1,2   A 27-year-old woman had been complaining of intermittent pain in the right lower abdominal quadrant for one year. A diagnosis of chronic appendicitis was made and the patient was operated on, but the appendix was normal. The pain persisted. On x-ray examination a right ovarian cyst was diagnosed, and the patient was operated on for the second time; the right ovary was normal. However, the cecum was markedly enlarged; it was excised along with the appendix and the adjacent part of the ileum. The postoperative course was normal.  Grossly, the surgical specimen (kept in the museum of the pathology department, No. 4025/1964/72,-847) consisted of the cecum with the appendix and the adjacent part of the ileum, the latter being
I'm Grateful for Breakfast
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2001)

Ad Libitum6 February 2001I'm Grateful for BreakfastJack Coulehan, MDJack Coulehan, MDSetauket, NY 11733 (Coulehan)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-3-200102060-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I, too, have arrived early for breakfastat the artists' colony. The frail womanwho never works without an assistant's helpstruggles to her seat beside me, carryinga plate of cantaloupe that she puts downand then turns back to get a second plate,which she places carefully beside the first.“Look at that! I have two plates of fruit.”resemble apricot pits in a dish... Author, Article, and Disclosure InformationAffiliations: Setauket, NY 11733 (Coulehan)Corresponding Author: Jack Coulehan, MD, 4 Townsend Court, Setauket, NY 11733. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 February 2001Volume 134, Issue 3Page: 202KeywordsCoffeeMilkShouldersTouchVision ePublished: 6 February 2001 Issue Published: 6 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Liver Tumors and Oral Contraceptives
Authors: Janet K. Baum
Journal: JAMA (1975)

To the Editor.—  I was both amused and annoyed at an article in the MEDICAL NEWS section ofThe Journal(231:451, 1975) concerning the possible association of hepatic cell adenomas and oral contraceptives.  In 1970 when I wrote the first paper on the subject, on the basis of three cases, I submitted it toThe Journalfor publication. It was rejected with a comment to the effect that the possible relationship was ridiculous and that possibly I should write up the case histories as interesting case reports and forget about the rest of the article.  In 1973, after I had seen four more cases, I rewrote the article and submitted to Lancet; it was published in the Oct 27, 1973, issue.  I am glad to see that editors ofThe Journalhave finally recognized the possible significance of this problem. It was somewhat discouraging, however, to note that the author of
Psychological Aspects of Non-Cardiac Chest Pain
Authors: A.W. Serlie, R.A.M. Erdman, J. Passchier, R.W. Trijsburg, F.J. ten Cate
Journal: Psychotherapy and Psychosomatics (1995)

Approximately 30% of patients visiting a cardiologist for the first time with complaints of chest pain appear to have normal coronary arteries. These patients generally have a higher prevalence of atypical chest pain, are relatively young, often female, in most cases suffer from panic disorder and have high scores on depression and anxiety scales. In this article some of the recent studies conducted in this particular line of research are reviewed and some possible explanations for the relationship between complaints and non-cardiac findings are presented. Furthermore, the ability of predicting non-cardiac chest pain from psychological factors and a range of follow-up studies are discussed. Finally the possibilities of treating cardiac phobia are mentioned.
Myocardial contrast echocardiography with a new calibration method can estimate myocardial viabilityin patients with myocardial infarction
Authors: Akio Yano, Hiroshi Ito, Katsuomi Iwakura, Ryusuke Kimura, Kouji Tanaka, Atsunori Okamura, Shigeo Kawano, Tohru Masuyama, Kenshi Fujii
Journal: Journal of the American College of Cardiology (2004)
Abstract 3890: Induction of cell cycle arrest and apoptosis in mantle cell lymphoma by AZD5438, a novel cyclin-dependent kinase inhibitor
Authors: Wann-Cheng Lo, Jim Growcott, David P. LeBrun, Peter A. Greer
Journal: Cancer Research (2010)

Abstract Mantle cell lymphoma (MCL) is recognized as a distinct subtype of B-cell lymphoma and it is characterized by cyclin D1 over-expression, which is caused by t(11;14)(q13;q32) translocation and unregulated cell cycle progression driven by increased cyclin-dependent kinase (CDK) activity. Accordingly, small inhibitors for CDKs represent a potential therapy for MCL. We are investigating a selective small molecule CDK inhibitor, AZD5438, which has nanomolar ranges of IC50 for cyclin E/CDK2, cyclin A/CDK2, cyclin B1/CDK1 and cyclin T/CDK9 and comparing its anti-tumor effects with a pan-CDK inhibitor, Flavopiridol. We hypothesize that inhibition of CDK1/2 by AZD5438 may lead to G1/S and G2 arrest, and therefore inhibit tumor cell proliferation and induce apoptosis in MCL. In Jeko-1 MCL cell lines, AZD5438 has shown both time- and dose-dependent inhibition of cell proliferation, inhibition of the phosphorylation of CDK substrates, and cell cycle arrest in G1 phase. The EC50 for AZD 5438 is 1μM as determined by inhibition of cell viability. We further developed an in vivo MCL xenograft assay: first, to guide the optimization of dosage and dosing schedule for clinical use; and second, to explore the selectivity and potency of this drug using phospho-histone H3 (Ser10) flow cytometry and phosopho-Rb (Ser249/Thr252) immunoblotting as our drug efficacy monitoring system. Recently we have established GFP transduced Jeko-1 cells and inoculated them into 8 to 12 week-old, immune-compromised NOD SCID mice. Investigations of AZD5438 drug dosage in this xenograft model are ongoing. Ultimately, this project is aimed at improving the treatment for MCL patients and reducing the toxic responses to the standard chemotherapeutic regimes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3890.