tbuckley/cabot-search huggingface dataset:
Statistical Indiscretion-Reply
Authors: Albert T. Derivan
Journal: JAMA (1983)

<h3>In Reply.—</h3> The study referred to in the previous letter is the first double-blind investigation of these drugs for the treatment of status epilepticus, and we are pleased that Dr Lee found only a minor statement that displeased him. Diazepam attained wide use for treatment of status without any controlled trials, and our study was designed to determine if lorazepam was as effective and safe as current treatment. The favorable outcome of our study has permitted other trials designed to determine the duration of action of lorazepam to proceed. Thus, while our study did not demonstrate a statistically significant difference between the two drugs, we believe, as does Dr Relman,<sup>1</sup>that "there is need also for preliminary but provocative new data" to be reported. The readers ofThe Journal, we believe, are aware of the implications of trends that have not achieved statistical significance and will be anticipating further
A semiautomatic tissue doppler-based tei index computation for evaluation of left ventricular function: A validation study in sheep with mitral regurgitation
Authors: Xiaokui Li, Xiang-Ning Li, Crispin H. Davies, Michael Jones, Ikuo Hashimoto, Arthur D. Zetts, Gordon K. Mack, Rosemary A. Rusk, David J. Sahn
Journal: Journal of the American College of Cardiology (2003)
Genetic and Molecular Basis of Cardiac Arrhythmias: Impact on Clinical Management Parts I and II
Authors: Silvia G. Priori, Jacques Barhanin, Richard N. W. Hauer, Wilhelm Haverkamp, Habo J. Jongsma, André G. Kleber, William J. McKenna, Dan M. Roden, Yoram Rudy, Ketty Schwartz, Peter J. Schwartz, Jeffrey A. Towbin, Arthur M. Wilde
Journal: Circulation (1999)

Abstract —Genetic approaches have succeeded in defining the molecular basis of an increasing array of heart diseases, such as hypertrophic cardiomyopathy and the long-QT syndromes, associated with serious arrhythmias. Importantly, the way in which this new knowledge can be applied to managing patients and to the development of syndrome-specific antiarrhythmic strategies is evolving rapidly because of these recent advances. In addition, the extent to which new knowledge represents a purely research tool versus the extent to which it can be applied clinically is also evolving. The present article represents a consensus report of a meeting of the European Working Group on Arrhythmias. The current state of the art of the molecular and genetic basis of inherited arrhythmias is first reviewed, followed by practical advice on the role of genetic testing in these and other syndromes and the way in which new findings have influenced current understanding of the molecular and biophysical basis of arrhythmogenesis.
Putting It Together: AIDS and the Millennium Development Goals
Authors: Robert Hecht, Anita Alban, Kate Taylor, Sarah Post, Nina B Andersen, Ryan Schwarz
Journal: PLoS Medicine (2006)

One of the most important and visionary global actions of recent years was the September 2000 commitment by 189 governments worldwide to [make] the right to development a reality for everyone and to [free] the entire human race from want. The movement to achieve sustainable reductions across all dimensions of extreme poverty has reached an unprecedented level with efforts primarily focused  and measured against the Millennium Development Goals. To date progress toward achieving these goals has been mixed: in some regions such as East Asia most countries have made important gains across the board and are thus on track or better for reaching many MDG targets. But in other regions most notably in sub-Saharan Africa a large number of countries are far behind and appear unlikely to reach or even come close to reaching their goals for 2015. The reasons for this are complex and often interlinked but one stands out as a major overarching threat to development: HIV/AIDS which kills more people than any other infectious disease and is the fourth-leading cause of death worldwide. The severe health impacts of AIDS are well documented. But AIDS also affects countries fundamental economic and social development performance and exerts detrimental effects  many of the other MDGs. AIDS will make it difficult if not impossible for many countries to achieve their MDG targets.   (excerpt)
TCT-838 Radial access in the very elderly
Authors: Leticia Blazquez, Felipe Hernandez, Lola Villagraz, Sandra Mayordomo, Jurado-Roman Alfonso, Carolina Granda, Julio García-Tejada, M. Teresa Velazquez, Agustin Albarran, Juan C. Tascon
Journal: Journal of the American College of Cardiology (2014)
US agrees to cheap drug imports--as Florida officials break fake drugs ring
Authors: F. Charatan
Journal: BMJ (2003)

In a move to cut the cost of prescription drugs in the United States, the House of Representatives last week passed (by 243 to 186) a bill permitting Americans to import cheaper drugs from Canada and Europe.

   ![][1] 

Chellie Pingree, Maine Democratic US Senate candidate, meets Norman Quirion, who claims he saved $2500 a year buying his drugs in Canada

Credit: MICHAEL C YORK/AP

The bill requires the Food and Drug Administration to establish a system allowing the import of FDA approved drugs from FDA approved facilities …

 [1]: /embed/graphic-1.gif
Empyema complicating a Pneumothorax Treated with Penicillin
Authors: L. A. Quirk
Journal: BMJ (1945)

MEDICAL JOUAL 11It is not suggested that penicillin alone was responsible for the happy issue.It is well recognized that the immunity responses may so alter that the outcome of such an illness may well transpire to be other than that first envisaged.Nevertheless I am convinced that penicillin in this instance achieved all that was expected of it, whereas in comparable illnesses of previous outbreaks the intensive use of sulphonamides failed to prevent several fatalities.With the probability of further virulent smallpox reaching our ports, it may well fall to others to confirm the impressions gained from the treatment of this patient.
Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting
Authors: Fanny Langlet, Barry E. Levin, Serge Luquet, Massimiliano Mazzone, Andrea Messina, Ambrose A. Dunn-Meynell, Eglantine Balland, Amelie Lacombe, Daniele Mazur, Peter Carmeliet, Sebastien G. Bouret, Vincent Prevot, Bénédicte Dehouck
Journal: Cell Metabolism (2013)
Managing violence in psychiatric hospitals.
Authors: C Stark, B Kidd
Journal: BMJ (1991)

nursing staff who give dialysis to a patient who is HIV positive?Although Ms Edwards's letter states that nurses who follow the standard guidelines "'will be protected from the risk of transmission of HIV," some of the expert advice we have received is that the possibility of a needlestick injury remains and, given the size of the needles and the blood volumes involved, the chances of such an injury from an HIV positive patient causing infection in the nurse may be significant.It might also seem sensible that HIV positive patients regularly receiving haemodialysis should be given dialysis in a separate facility, as is done for hepatitis B positive patients, and this obviously will require that these issues have been fully discussed with all members of the nursing staff.I understand that the Department of Health will soon be issuing some further guidelines about HIV testing, but it seems that these will be rather neutral and, once again, not of much help to the clinicians actually having to deal with the issue.Similarly, ex cathedra statements from the Royal College ofNursing about this complex and sensitive topic are unlikely to be of much practical guidance unless they provide the stimulus for the wide ranging debate about these issues which is required.
Suspected Pneumocystis carinii pneumonia with a negative induced sputum examination. Is early bronchoscopy useful?
Authors: L Huang, F M Hecht, J D Stansell, R Montanti, W K Hadley, P C Hopewell
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

In U.S. patients with the acquired immunodeficiency syndrome (AIDS), Pneumocystis carinii pneumonia is the most frequent AIDS-defining opportunistic infection. Sputum induction and bronchoscopy are effective techniques for obtaining specimens used to identify P. carinii although debate continues over their optimal use, specifically whether to perform bronchoscopy after a negative induced sputum examination for P. carinii. To evaluate the usefulness of bronchoscopy in this situation, we reviewed all cases of suspected P. carinii pneumonia in which sputum induction for P. carinii was performed at San Francisco General Hospital during a 4-yr period. Bronchoscopy, performed after a negative induced sputum examination, yielded a diagnosis in 50.5% of evaluations. The most frequent diagnoses were P. carinii pneumonia (192), tracheobronchial Kaposi's sarcoma (93), tuberculosis (28), and Cryptococcus neoformans pneumonia (9). Bronchoscopy provided either the only or an earlier diagnosis in 64.3% of tuberculosis cases. Bronchoscopy with BAL was free of complications, and, importantly, a negative BAL examination for P. carinii allowed physicians to discontinue empiric P. carinii pneumonia treatment in 95%. In patients with suspected P. carinii pneumonia with a negative induced sputum examination for P. carinii, early bronchoscopy with BAL should be performed.
Eradication of Brucellosis
Authors: W. R. Kerr, J. Rankin
Journal: BMJ (1963)

it produces any incidence of cardiac arrest in non- burned patients.On the other hand there is evidence that in burned patients the incidence of cardiac arrest during induction is 1:2091 and 1:250.2There are now 18 recorded instances of cardiac arrest during induction in burned patients, and furthermore five patients suffered two episodes of cardiac arrest on different occasions.A review of these cases suggested that there may be a distorted pharmacological response rather than an exaggerated reaction to intubation.Dr. Pooler may well be right in suggesting that sympathetic overactivity may be the explanation in some cases, and since it is known that suxamethonium can produce sympathetic and parasympathetic stimulation I believe that burned patients may have an idiosyncrasy to this drug and no evidence has yet been produced to deny this suggestion.Whatever the mechanism, however, I believe that it is important to entertain this possibility and it was hoped that by drawing attention to this fact we would decrease the incidence and not increase it as Dr. Langton Hewer suggests.Dr. Azzopardi's impression of the increased incidence of cardiac arrest associated with anaesthesia can be appreciated if the techniques he describes are fairly common practice, as he suggests, but can this impression really be substantiated ?Dr. Ayre's suggestion that the period of apnoea following suxamethonium between pulmonary ventila- tion with the mask and with an endotracheal tube in situ may be of importance is interesting, but my observations in this centre suggest that 20-25 seconds is a more realistic time for the average anaesthetist in the average case.Unless there is considerable pulmonary pathology this period of time will not produce hypoxia, since it is of shorter duration than one circulation time.-Iam, etc.
Medical Expert Testimony: Advanced Syllabus for Healthcare Professionals
Authors: Alan G. Williams
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biliary repair and carcinogenesis are mediated by IL-33–dependent cholangiocyte proliferation
Authors: Jun Li, Nataliya Razumilava, Gregory J. Gores, Stephanie Walters, Tatsuki Mizuochi, Reena Mourya, Kazuhiko Bessho, Yui-Hsi Wang, Shannon S. Glaser, Pranavkumar Shivakumar, Jorge A. Bezerra
Journal: Journal of Clinical Investigation (2014)

Injury to the biliary epithelium triggers inflammation and fibrosis, which can result in severe liver diseases and may progress to malignancy. Development of a type 1 immune response has been linked to biliary injury pathogenesis; however, a subset of patients with biliary atresia, the most common childhood cholangiopathy, exhibit increased levels of Th2-promoting cytokines. The relationship among different inflammatory drivers, epithelial repair, and carcinogenesis remains unclear. Here, we determined that the Th2-activating cytokine IL-33 is elevated in biliary atresia patient serum and in the livers and bile ducts of mice with experimental biliary atresia. Administration of IL-33 to WT mice markedly increased cholangiocyte proliferation and promoted sustained cell growth, resulting in dramatic and rapid enlargement of extrahepatic bile ducts. The IL-33-dependent proliferative response was mediated by an increase in the number of type 2 innate lymphoid cells (ILC2s), which released high levels of IL-13 that in turn promoted cholangiocyte hyperplasia. Induction of the IL-33/ILC2/IL-13 circuit in a murine biliary injury model promoted epithelial repair; however, induction of this circuit in mice with constitutive activation of AKT and YAP in bile ducts induced cholangiocarcinoma with liver metastases. These findings reveal that IL-33 mediates epithelial proliferation and suggest that activation of IL-33/ILC2/IL-13 may improve biliary repair and disruption of the circuit may block progression of carcinogenesis.
Association of the PRO12ALA polymorphism of the PPAR-γ2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects
Authors: L. Niskanen, V. Lindi, A. Erkkilä, K. Sivenius, J. Luoma, S. Ylä-Herttuala, M. Laakso, M.I.J. Uusitupa
Journal: Metabolism (2003)
EFFECT OF THE INJECTION OF BILE ON THE CIRCULATION
Authors: John H. King, Hugh A. Stewart
Journal: The Journal of Experimental Medicine (1909)

1. We have confirmed previous work which shows that the injection of bile increases the tone of the vagus nerve, and that this action can be abolished after the administration of atropine. 2. We have found that the amount of bile salts in a lethal dose of pig's bile for dog's will, if inejcted alone, produce neither a fall in blood pressure nor a slowing in rate. 3. We have found that the amount of pigment in a lethal dose of the bile will, if injected alone, cause death with slowing of the heart and lowering of blood pressure. 4. We have found that the bile pigment in combination with calcium or sodium is less toxic than uncombined pigment. 5. We have found that in experimentally produced jaundice the calcium content of the blood is increased, while that of the liver, muscle and brain are decreased. 6. We are of the opinion that increase in calcium in the blood is a protective mechanism against the circulating pigments of obstructive jaundice.
INFECTION OF A PEACOCK WITH ERYSIPELOTHRIX RHUSIOPATHAE, FOLLOWED BY A CASE OF HUMAN ERYSIPELOID.
Authors: AVERIL W. GREENER
Journal: British Journal of Dermatology (1939)

Journal Article INFECTION OF A PEACOCK WITH ERYSIPELOTHRIX RHUSIOPATHÆ, FOLLOWED BY A CASE OF HUMAN ERYSIPELOID. Get access AVERIL W. GREENER, Dip.Bact.(London), M.R.C.V.S. AVERIL W. GREENER, Dip.Bact.(London), M.R.C.V.S. Research Institute in Animal Pathology, Royal Veterinary College, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 51, Issue 8-9, 1 August 1939, Pages 372–376, https://doi.org/10.1111/j.1365-2133.1939.tb10809.x Published: 01 August 1939
Mechanisms of Hepatocarcinogenicity of Peroxisome-Proliferating Drugs and Chemicals
Authors: B G Lake
Journal: The Annual Review of Pharmacology and Toxicology (1995)

Over the past two decades, deadly coronaviruses, with the most recent being the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019 pandemic, have majorly challenged public health. The path for virus invasion into humans and other ...Read More
255 What is the place for intra-arterial injection of 131I-labeled-iodized oil (LIPIOCIS®) in palliative treatment of hepato-cellular carcinoma?
Authors: E. Germain, M.N. Hilleret, C. Sengel, J.P. Vuillez, J.P. Zarski, V. Leroy
Journal: Journal of Hepatology (2006)
URTICARIA DUE TO COLD
Authors: Richard L. Sutton
Journal: JAMA (1934)

To the Editor:—  Under current comment, September 29, you discuss physical allergy, noting the reporting of cases of urticaria due to cold in 1905 by Fraser and by Osler. I would call attention to an article on the etiology of urticaria by George Henry Fox in 1883 ( J. Cutan. & Ven. Dis.  1 :108, 1883).  He wrote: Munchmeyer ( Berl. klin. Wchnschr. , May 17, 1875) relates the case of a soldier who suffered from urticaria upon every exposure to a cold wind. It usually appeared in the form of three large circular wheals upon the cheeks and chin. Ungar ( Berl. klin. Wchnschr. , Nov. 28, 1881) reports the case of a patient who, after a short stay in the open air, suffered from an extensive eruption of urticaria, followed in a few minutes by an attack of bronchial asthma. Upon return to a warm atmosphere, the shortness of breath gradually subsided and
REPORT CXVI. THE INFLUENCE OF THE UNSATURATED FATTY ACIDS IN TUBERCULOSIS
Authors: O. T. Williams, Chas. E. P. Forsyth
Journal: BMJ (1909)

by tuberculous disease elsewhere-for example, larynx, bones, or glands.In the last 18 cases examined we had previously demonstrated tubercle bacilli in the sputum.The result of these examinations is tabulated below, along with the age, lung condition, and duration of illness of each patient.In every case four slides were pre- pared, and each slide was examined for at least an hour.
Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome
Authors: Katiuchia Uzzun Sales, Andrius Masedunskas, Alexandra L Bey, Amber L Rasmussen, Roberto Weigert, Karin List, Roman Szabo, Paul A Overbeek, Thomas H Bugge
Journal: Nature Genetics (2010)
Radioisotope Photoscanning as a Diagnostic Aid in Cardiovascular Disease
Authors: N. David Charkes, David M. Sklaroff
Journal: JAMA (1963)

RADIOISOTOPE scanning of the heart and aorta was first described by Rejali et al in 1958<sup>1</sup>and has subsequently been shown to be a safe, simple, and useful procedure for the diagnosis of pericardial effusion and aortic aneurysm.<sup>2-5</sup>Since beginning our studies early in 1961 we have used I131 human serum albumin (IHSA) and I 131-sodium iodipamide (Cholografin sodium) as scanning agents. The latter is preferable because its rapid clearance by the liver<sup>5-7</sup>delivers a whole-body radiation dose less than 5% of that of an equal amount of IHSA,<sup>5</sup>the agent used in the original investigations.<sup>1</sup> We have employed a commercial scanner for these studies.<sup>8</sup>This instrument utilizes a pulse-height analyzer and background cut-off circuit, with contrast enhancement of the remaining pulses. Isotope distribution is displayed as black or grey dots on a clear roentgen film, the shading being related to the radioisotope concentration
Cholecystectomy in Patient with Pacemaker
Authors: Carl W. Walter
Journal: JAMA (1971)

<h3>To the Editor.—</h3> A basic answer to "Cholecystectomy in Patient with Endocardial Demand Pacemaker" (<b>217</b>:832, 1971) is that cholecystectomy can be accomplished safely without the use of electrocautery. That technique is a nonessential convenience to the surgeon. Where increased risk is suspected, good judgement dictates omission of the questioned technique.
Alphavirus-based Vaccines Encoding Nonstructural Proteins of Hepatitis C Virus Induce Robust and Protective T-cell Responses
Authors: Peng Peng Ip, Annemarie Boerma, Joke Regts, Tjarko Meijerhof, Jan Wilschut, Hans W Nijman, Toos Daemen
Journal: Molecular Therapy (2013)

An absolute prerequisite for a therapeutic vaccine against hepatitis C virus (HCV) infection is the potency to induce HCV-specific vigorous and broad-spectrum T-cell responses. Here, we generated three HCV vaccines based on a recombinant Semliki Forest virus (rSFV) vector expressing all- or a part of the conserved nonstructural proteins (nsPs) of HCV. We demonstrated that an rSFV vector was able to encode a transgene as large as 6.1 kb without affecting its vaccine immunogenicity. Prime-boost immunizations of mice with rSFV expressing all nsPs induced strong and long-lasting NS3-specific CD8(+) T-cell responses. The strength and functional heterogeneity of the T-cell response was similar to that induced with rSFV expressing only NS3/4A. Furthermore this leads to a significant growth delay and negative selection of HCV-expressing EL4 tumors in an in vivo mouse model. In general, as broad-spectrum T-cell responses are only seen in patients with resolved HCV infection, this rSFV-based vector, which expresses all nsPs, inducing robust T-cell activity has a potential for the treatment of HCV infections.