Multiple Autoimmune Diseases with Bilateral Optic Atrophy and Lipodystrophy
Authors: WENDELL A. WILSON
Journal: Annals of Internal Medicine (1978)

Brief Reports1 July 1978Multiple Autoimmune Diseases with Bilateral Optic Atrophy and LipodystrophyWENDELL A. WILSON, M.D., M.R.C.P., J. G. PATRICK SISSONS, M.B., M.R.C.P., OWEN S. MORGAN, M.D., M.R.C.P., F.A.C.P.WENDELL A. WILSON, M.D., M.R.C.P.Search for more papers by this author, J. G. PATRICK SISSONS, M.B., M.R.C.P.Search for more papers by this author, OWEN S. MORGAN, M.D., M.R.C.P., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-1-72 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is much interest in the lipoatrophic syndromes and their relation to autoimmune disorders, complement, and antibodies to membrane receptors (1-4). We report here the case of a patient with an unusual form of localised lipodystrophy characterized by bilateral symmetrical lipoatrophy within the third lumbar dermatome. Over 20 years this patient successively developed thyrotoxicosis, myasthenia gravis, and idiopathic thrombocytopenic purpura and also had bilateral optic atrophy and sensorineural deafness.Our patient was first admitted to the University Hospital of the West Indies in 1955, at age 16, with palpitations, weight loss, and dyspnoea of 5 years' duration. Three years earlier...References1. OSEIDBECK-NIELSENPEDERSENSØVIK SHOO: Decreased binding of insulin to its receptor in patients with congenital generalized lipodystrophy. N Engl J Med 296:245-248, 1977 CrossrefMedlineGoogle Scholar2. ALARCÓN-SEGOVIARAMOS-NIEMBRO DF: Association of partial lipodystrophy and Sjögren's syndrome (letter). Ann Intern Med 85:474-475, 1976 LinkGoogle Scholar3. SISSONSWESTFALLOWSWILLIAMSBOUCHERAMOSPETERS JRJDBND: The complement abnormalities of lipodystrophy. N Engl J Med 294:461-465, 1976 CrossrefMedlineGoogle Scholar4. ROONEY P: Case of lipodystrophy. Br Med J 1:464, 1970 CrossrefMedlineGoogle Scholar5. SHELLEYIZUMI WA: Annular atrophy of the ankles. Arch Dermatol 102:326-329, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of the West Indies Kingston Jamaica PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySubcutaneous FatLipodystrophy following hepatitis infection: A causative relationship?Krankheiten des subkutanen FettgewebesPartial Lipodystrophy, Polycystic Ovary Syndrome and Proteinuria: A Common Link to Insulin Resistance?Barraquer-Simons lipodystrophy, Raynaud's phenomenon and cutaneous vasculitisPartial lipodystrophy, mesangiocapillary glomerulonephritis, and complement dysregulationPartial Lipodystrophy Associated with Juvenile Dermatomyositis: Report of Two CasesKrankheiten des subkutanen FettgewebesA case of partial face-sparing lipodystrophy combining features of generalized lipodystrophyJuvenile dermatomyositis associated with partial lipoatrophyPartial lipodystrophy in coeliac disease.Systemic lupus erythematosus in a patient with partial lipodystrophyAnnular atrophic connective tissue panniculitis of the anklesAssociation maladie de Basedow et purpura thrombopénique auto-immunLupus Erythematosus PanniculitisMiscellaneous Conditions Associated with Arthritis in ChildrenThe histopathology of localized lipoatrophyTOTAL LIPODYSTROPHY - A REPORT OF A CASE WITH PERIPHERAL NEUROPATHY and GLOMERULONEPHRITIS 1 July 1978Volume 89, Issue 1Page: 72-73KeywordsAntibodiesAtrophyAutoimmune diseasesDeafnessIdiopathic thrombocytopenic purpuraLipodystrophyMyasthenia gravisWeight loss Issue Published: 1 July 1978 PDF downloadLoading ...