tbuckley/cabot-search huggingface dataset:
Adenosine-related Ventricular Asystole
Authors: Patrick L. McCollam
Journal: Annals of Internal Medicine (1993)

Letters15 February 1993Adenosine-related Ventricular AsystolePatrick L. McCollam, MD, Walter E. Uber, MD, and Adrian B. Van Bakel, MDPatrick L. McCollam, MDSearch for more papers by this author, Walter E. Uber, MDSearch for more papers by this author, and Adrian B. Van Bakel, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-4-199302150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Currently, no published guidelines address the administration of adenosine by central venous access [1]. We describe three patients who received 3 or 6 mg (0.035 to 0.097 mg/kg) of adenosine and experienced heart block or ventricular asystole lasting from 3 to 21 seconds (see Table 1 below). A fourth exhibited no adverse effects after 3 mg (0.033 mg/kg) of adenosine. All were patients in intensive care who received adenosine diagnostically. None had known conduction abnormalities. Two were heart transplant recipients experiencing severe rejection.Table 1. Patient Characteristics* Potential drug interactions with adenosine may ...References1. Faulds D, Chrisp P, Buckley MM. Adenosine. An evaluation of its use in cardiac diagnostic procedures, and in the treatment of paroxysmal supraventricular tachycardia. Drugs. 1991; 41:596-624. Google Scholar2. Pelleg A, Porter S. The pharmacology of adenosine. Pharmacotherapy. 1990; 10:157-74. Google Scholar3. Watt AH, Bernard MS, Webster J, Passani SL, Stephens MR, Routledge PA. Intravenous adenosine in the treatment of supraventricular tachycardia: a dose-ranging study and interaction with dipyridamole. Br J Clin Pharmacol. 1986; 21:227-30. Google Scholar4. Ellenbogen KA, Thames MD, DiMarco JP, Sheehan H, Lerman BB. Electrophysiological effects of adenosine in the transplanted human heart: evidence of supersensitivity. Circulation. 1990; 81:821-8. Google Scholar5. Sellers TD, Kirchhoffer JB, Modesto TA. Adenosine: a clinical experience and comparison with verapamil for the termination of supraventricular tachycardias. In: Pelleg A, Michelson EL, Driefus LS; eds. Cardiac Electrophysiology and Pharmacology of Adenosine and ATP. New York: Liss; 1987:283-99. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUnmasking Adenosine: The Purinergic Signalling Molecule Critical to Arrhythmia Pathophysiology and ManagementTachyarrhythmienProarrhythmic Effects of Adenosine: One Decade of Clinical DataLife-threatening alterations in heart rate after the use of adenosine in atrial flutterIs adenosine really safe? 15 February 1993Volume 118, Issue 4Page: 315-316KeywordsAdenosineAdverse reactionsDrug interactionsDrugsEffective doseHeartPatientsTachycardiaTransplantation Issue Published: 15 February 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
THE THERAPEUTIC VALUE OF MASSAGE IN ACUTE DISEASES.
Authors: JAY W. SEAVER
Journal: JAMA (1905)

The question of nutrition underlies the activity of every organ and tissue of the body. In general, we may say that nutrition is dependent on circulation, and that this is adouble process, or rather a single nutrient current that becomes divided into two in thecapillary regions. At the point of division it is not only distributed by two entirely distinct sets of tubes, but the rate of flow is widely different, as is the quality of the contained nutrient stream. The blood is ordinarily looked on as the great nutrient tissue of the body. It has its well-defined cells which carry on individual functions of widely different character, according to the nature of the corpuscle, but the intervening plasma, or stroma substance, lying between these cells, is the carrier of most of the nutrition that the various structures of the body need, as it
Clinical efficacy of high-dose dexamethasone with maintenance dexamethasone/alpha interferon in patients with primary systemic amyloidosis: results of United States Intergroup Trial Southwest Oncology Group (SWOG) S9628
Authors: Madhav V. Dhodapkar, Mohamad A. Hussein, Erik Rasmussen, Alan Solomon, Richard A. Larson, John J. Crowley, Bart Barlogie
Journal: Blood (2004)
Worldwide study links two new genetic variants to breast cancer
Authors: S. Mayor
Journal: BMJ (2015)

A worldwide study analysing DNA from 100 000 women has identified two new genetic variants associated with raised risk for the most common form of breast cancer.

Researchers analysed DNA from just over 43 000 European women with breast cancer and a similar number of controls, as well as from 5795 women of Asian ancestry with breast cancer and 6624 matched controls. Fine mapping analysis identified two genetic variants on a recently …
The Muscles of the Eyeball, and the Nervous Influences which regulate their Actions
Authors: H. Lee
Journal: BMJ (1851)

MOST of the voluntary actions of our bodies are performed by us with reference only to the end which we have in view, while we generally remain unmindful of the mechanism by means of which they are pro- duced; and with respect to the involuntary motions, which are the most important of all, provision is made for their continuance day after day, quite independently of our will, or even of our consciousness.Each muscular fibre employed in the former set of movements is under the influence of, and guided by, common sensation, or what may be termed the muscular sense.Thlis may be appreciated by, and may act in concert with, the 'will.Thus we are quite conscious of tlle amount of effort made in endeavouring to raise a weight, although we do not move it.This sense it is which gives us the knowledge of the exact amount of force required in different muscles, in order that thev may concur in producing any movement of the body.If this sense is impaired, or ceases to act in conjunction with the will, the muscles act irregularly, imperfectly, or not at all.When, for instance, the nerve of sensation has been paralysed in the head of a horse, the lower lip will hang, and the animal will be unable to eat its food, because it does notfeel the amount of effort required in the several muscles to produce a combined action.Or, again, when a person loses sensation in his lower extremities, although the power of motion is unimpaired, yet will he be unable to walk, because he has no means of knowing or of indicating to each muscle the exact share which it should take in balancing his body.This sense may, however, be supplied by another under certain circumstances.Thus, well-known cases have occurred, in which the power of sensation was lost in the hand or arn, and in which anything placed in the hand would drop, the muscles receiving no intimation of the amount of action requiired of them.But, in such instances, if the eye were kept fixed on the object, it could be retained VOL.rIt.
Hydroxymethylglutaryl Coenzyme A Reductase Inhibitors Modify the Inflammatory Response of Human Macrophages and Endothelial Cells Infected With <i>Chlamydia pneumoniae</i>
Authors: H. Kothe, K. Dalhoff, J. Rupp, A. Müller, J. Kreuzer, M. Maass, H. A. Katus
Journal: Circulation (2000)

Background —In patients with atherosclerosis, hepatic hydroxymethylglutaryl coenzyme A reductase (CSE) inhibitors may reduce the activation of inflammation. Because Chlamydia pneumoniae infection has been linked to coronary artery disease through the induction of plaque inflammation, we investigated whether cerivastatin affects the infection rate of human macrophages and endothelial cells (ECs) and their proinflammatory activation after chlamydial infection. Methods and Results —Macrophages were collected from the alveolar compartment of 6 volunteers and 10 patients with chronic bronchitis. ECs were obtained from 10 umbilical cords. The C. pneumoniae strain CWL was incubated with macrophages or ECs in the presence and absence of the CSE inhibitor cerivastatin. The infection rate was determined by immunofluorescence microscopy. The release of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), and tumor necrosis factor (TNF)-α was quantified by ELISA. The release of oxygen radicals was determined by ferricytochrome assay. Infection rates were tendentially lower after the preincubation of macrophages with CSE inhibitors (17.2% versus 9.3% and 18.2% versus 10.4%, respectively; P= NS). The secretion of MCP-1, IL-8, and TNF-α by infected macrophages from volunteers increased. Coincubation with cerivastatin resulted in significantly lower MCP-1 and IL-8 production, whereas the release of TNF-α remained unaffected. Similar effects regarding chemokine release were observed in ECs. Conclusions —CSE inhibitors modify the inflammatory response of human immune cells to C. pneumoniae . This finding could be relevant for the therapeutic potential of CSE statins in patients with atherosclerosis and C. pneumoniae infection.
Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients
Authors: Ayano Fujita, Masaru Ihira, Ryota Suzuki, Yoshihiko Enomoto, Hiroko Sugiyama, Ken Sugata, Sadao Suga, Yoshizo Asano, Hiroshi Yagasaki, Seiji Kojima, Kimikazu Matsumoto, Koji Kato, Tetsushi Yoshikawa
Journal: Journal of Infection (2008)
Continuous Monitoring for Ventricular Arrhythmias During Exercise Tests
Authors: Elliott Antman
Journal: JAMA (1979)

Exercise stress testing is being increasingly used to verify exercise-induced arrhythmia and to aid in assessing antiarrhythmic drug efficacy. The true prevalence of ventricular arrhythmia during exercise testing is underestimated by means other than continuous monitoring. We compared the yield of ventricular premature beats (VPBs) between a continuous recording system ("trendscription") and intermittent monitoring among 39 patients undergoing a total of 50 consecutive exercise studies. By intermittent monitoring, 22 (44%) of 50 of the exercise tests demonstrated VPBs; with trendscription, 31 (62%) exhibited such arrhythmia. Most striking, however, was a sixfold increase in the disclosure of complex and repetitive forms of VPBs (56 vs nine episodes). Thus, this form of monitoring presents a cost-efficient, on-line method that allows concentration on the patient during exercise as well as clear recording of all arrhythmic events.
Analysis of Results of Kidney Transplantation
Authors: Ramon Patel, John P. Merrill, William A. Briggs
Journal: New England Journal of Medicine (1971)

MANY kidney-transplant recipients have preformed antileukocyte antibodies as a result of previous blood transfusions, kidney transplants or pregnancy.1 When these antibodies are specific for the donor's leukocytes (as indicated by a positive crossmatch test of the recipient's serum and the donor's cells), immediate failure of the transplant is highly probable.2 , 3 Even if these cases are excluded, however, it is our clinical impression that results of kidney transplantation in sensitized recipients are inferior to those in unsensitized recipients. Our analysis of 84 kidney transplants in 79 recipients performed between February 2, 1966, and December 18, 1970, appear to support this impression. . . .
Highlights of the 1988 EDUCATION ISSUE
Authors: Anne E. Crowley
Journal: JAMA (1988)

Eighty-eight years ago, when<i>JAMA</i>first published an EDUCATION ISSUE, little or no attention was being given to medical school entrance requirements or to the qualifications of teachers in medical schools. The 1901 publication of data on medical education in the United States showed the need for improvement in standards. During the intervening years, medical education has seen many changes. In 1988, the medical education community is concerned about physician competence, ie, what elements of professional knowledge, skills, behavior, and attitudes make for a competent physician. The editorial by Dr Martini argues for a redefinition of<i>professional competence</i>and for an assessment of the mechanisms for evaluating competence. <h3>Medical School Enrollment</h3> The number of applicants to US schools accredited by the Liaison Committee on Medical Education for the 1987-1988 academic year decreased by 3 200 individuals. Of the 28123 applicants, 17027 students were accepted by at least one school for
The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice
Authors: Chiara Bacchelli, Karen F. Buckland, Sylvie Buckridge, Ulrich Salzer, Pascal Schneider, Adrian J. Thrasher, H. Bobby Gaspar
Journal: Journal of Allergy and Clinical Immunology (2011)
The ESC Textbook of Intensive and Acute Cardiac Care
Authors: David P. Strum
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluating the Outcome from Intensive Care
Authors: LAWRENCE B. TILIS
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 August 1986Evaluating the Outcome from Intensive CareLAWRENCE B. TILIS, M.D.LAWRENCE B. TILIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-307_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I found the article by Knaus and colleagues (1) fascinating to say the least. I am concerned, however, that no mention was made of the physicians who were involved in the treatment of the patients. The article seems to assume that the quality of the physician involved was equal in all the institutions. I am not certain that this conclusion is justified and wondered how the analysis handled this problem....Reference1. KNAUS W, DRAPER E, WAGNER D, and ZIMMERMAN J. An evaluation of outcome from intensive care in major medical centers. Ann Intern Med. 1986;104:410-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAWRENCE B. TILIS, M.D.Affiliations: 10 North Main Street; Pittsford, NY 14534 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1986Volume 105, Issue 2Page: 307-308KeywordsPatients ePublished: 1 December 2008 Issue Published: 1 August 1986 PDF downloadLoading ...
Laminectomy for Complete Paraplegia Produced by Angular Curvature of the Spine
Authors: A. Gray
Journal: BMJ (1895)

LAMINECTOMY.'It_ [TMt,7:=T 807 2 inches posteriorly to the meatus.The mastoid region itself appeared healthy, and was not tender on percussion.On the right side the meatus was full of pus, the membrana tympani was perforated, and there was an extremely tender elastic swelling the size of a split walnut behind the mastoid process, but here again the mastoid region itself was normal -and not tender.There was no swelling nor tenderness in the neck or in the course of the internal jugular vein of either side.No evidence of septic pneumonia, bronchitis, or vis- ceral disease was found.The diagnosis of suppurative otitis media, with extension into the mastoid cells of each side, was made, and in addi- tion, and of most immediate importance, septic thrombosis -of one lateral sinus, but beyond the fact of the falling in of the posterior wall of the right meatus there were no sym- -ptoms indicating on which side the disease was more serious or which sinus was thrombosed.The patient was anasthetised and the head shaved.The *extent of the swelling on the left side was then seen moreclearly.An incision was made through its lowest part over the postero-inferior angle of the parietal bone, and pus and -blood clot escaped.The floor of the cavity was composed of
Doctors' retainer scheme in Scotland: time for change?
Authors: A. Douglas, I. McCann
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objectives</b>: To describe the present doctors9 retainer scheme in Scotland and ascertain the need for change. <b>Design</b>: Semistructured postal questionnaires to current and past members of the doctors9 retainer scheme and general practitioner employers. <b>Setting</b>: Scotland, October to December 1994. <b>Subjects</b>: 152/160 current and 104/124 former members responded together with 101/118 general practitioner employers. <b>Results</b>: 93% of members currently working in general practice were either vocationally trained or had previously worked as principals. 84% of current members held postgraduate qualifications. 73% of former members had left the scheme within 4 years and 72% of current members had been with the scheme for 4 years or less. 66% of current members said that the scheme prevented them from leaving medicine. Both members and employers were dissatisfied with the current limit of two working sessions per week, 77% of employers wanting it increased. 61% of current members would not have joined the scheme if suitable part time work had been available and 46% of those would have preferred to work flexibly, up to 5 sessions per week. 52% of members do not receive BMA rates of pay and, of those, 46% work more than 3.5 hours per session. <b>Conclusion</b>: The scheme appears to be appreciated and would be more so if inconsistencies in pay and conditions were addressed. An increase in the permitted number of weekly sessions would enable these highly qualified doctors to maintain their skills and confidence.
Antibiotic prophylaxis of neonatal group B streptococcal infections.
Authors: C Van Oppen, R Feldman
Journal: BMJ (1993)

We should probably see that again; bring it back next week."The "it" was presumably the wound rather than the child, but the woman was upset that she had no time to ask if her child would be all right.In the second case a woman asking questions about her leg ulcer was told, "Look, dear, you go away and make up your mind what you want done, and then we might be able to help you."When the NHS was founded, people were grateful to have access to free health care and accepted not being treated as equals.But we should be further on in the long march from paternalism.The NHS reforms and the patient's charter are designed to try to make the health service more customer or patient oriented, but structural reforms and exhortations will never be enough on their own.Deeper, cultural changes are needed, and total quality management-with its insistence that only the patient can define quality-is the way forward.This should be familiar to doctors.The first lesson we learn at medical school is to listen to the patient.
THE PSYCHIATRIST AND THE RELEASE OF PATIENT INFORMATION
Authors: MARC H. HOLLENDER
Journal: American Journal of Psychiatry (1960)

In this article the relationship of the hospital psychiatrist and the agencies requesting information and/or recommendations concerning patients has been examined. Two questions immediately arose: 1. Whose agent is the psychiatrist? and 2. Is he oriented to therapy or to public service or does he believe that he can encompass both objectives? The types of requests for information and recommendations were enumerated. It has apparently been assumed that many requests are reasonable and should be answered. The problem then was to determine which ones were reasonable and to decide how they should be answered. It was suggested that the first issue should be that of questioning whether the psychiatrist should supply any information. This was then considered in terms of its effect on psychotherapy. Obviously, therapy will be altered if the patient sees the psychiatrist as a possible informer as well as a helper. If information is supplied, is it really useful? This brings us face to face with the issue of how well predictions can be made in instances involving many variables, some known but many unknown, which can be arranged in an exceedingly large number of combinations. Some comments were, also, made on the misleading effect of labelling. The expectation that requests would be answered and the practice of complying, in part, stems from the general practice of medicine. Too little attention has been paid to significant social factors. It was suggested that psychiatrists might be seduced to claim that they possessed special ability to foretell the future. As a result "educated" guesses might be dispensed as facts. During a period of hospitalization, the patient's family might have to be provided with information to participate in immediate decision-making. This stands in sharp contrast, however, to making decisions about the patient's ability to work or attend school after he has left the hospital and is assuming responsibility for his own welfare.
Difference in life expectancy between rich and poor is widening
Authors: K. Abbasi
Journal: BMJ (1997)

Men in affluent Cambridge and Surrey live almost seven years longer than men in Manchester, Liverpool, and in inner London, according to a study published this week. The data also showed that although women live longer than men in all areas the difference is most marked in poorer parts of the country.

Researchers from the National Institute of Epidemiology at the University of Surrey analysed mortality data for English health authorities from 1984–94 and found …
Dynamics of Thymus-Colonizing Cells during Human Development
Authors: Rima Haddad, Fabien Guimiot, Emmanuelle Six, Frederic Jourquin, Niclas Setterblad, Edmond Kahn, Micael Yagello, Cecile Schiffer, Isabelle Andre-Schmutz, Marina Cavazzana-Calvo, Jean Claude Gluckman, Anne-Lise Delezoide, Françoise Pflumio, Bruno Canque
Journal: Immunity (2006)