tbuckley/cabot-search huggingface dataset:
Common skin cancers in porokeratosis
Authors: E. Maubec, P. Duvillard, A. Margulis, B. Bachollet, G. Degois, M-F. Avril
Journal: British Journal of Dermatology (2005)

Journal Article Common skin cancers in porokeratosis Get access E. Maubec, E. Maubec Departments of Dermatology, *Pathology and †Surgery, Institut Gustave Roussy, Villejuif, France E‐mail: eve.maubec@bch.ap‐hop‐paris.fr Search for other works by this author on: Oxford Academic Google Scholar P. Duvillard, P. Duvillard Departments of Dermatology, *Pathology and †Surgery, Institut Gustave Roussy, Villejuif, France E‐mail: eve.maubec@bch.ap‐hop‐paris.fr Search for other works by this author on: Oxford Academic Google Scholar A. Margulis, A. Margulis Departments of Dermatology, *Pathology and †Surgery, Institut Gustave Roussy, Villejuif, France E‐mail: eve.maubec@bch.ap‐hop‐paris.fr Search for other works by this author on: Oxford Academic Google Scholar B. Bachollet, B. Bachollet Departments of Dermatology, *Pathology and †Surgery, Institut Gustave Roussy, Villejuif, France E‐mail: eve.maubec@bch.ap‐hop‐paris.fr Search for other works by this author on: Oxford Academic Google Scholar G. Degois, G. Degois Departments of Dermatology, *Pathology and †Surgery, Institut Gustave Roussy, Villejuif, France E‐mail: eve.maubec@bch.ap‐hop‐paris.fr Search for other works by this author on: Oxford Academic Google Scholar M‐F. Avril M‐F. Avril Departments of Dermatology, *Pathology and †Surgery, Institut Gustave Roussy, Villejuif, France E‐mail: eve.maubec@bch.ap‐hop‐paris.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 6, 1 June 2005, Pages 1389–1391, https://doi.org/10.1111/j.1365-2133.2005.06639.x Published: 01 June 2005
Chronic Central Serous Chorioretinopathy Is Associated with Genetic Variants Implicated in Age-Related Macular Degeneration
Authors: Eiko K. de Jong, Myrte B. Breukink, Rosa L. Schellevis, Bjorn Bakker, Jacqueline K. Mohr, Sascha Fauser, Jan E.E. Keunen, Carel B. Hoyng, Anneke I. den Hollander, Camiel J.F. Boon
Journal: Ophthalmology (2014)
Chronic Infections and the Risk of Carotid Atherosclerosis
Authors: Stefan Kiechl, Georg Egger, Manuel Mayr, Christian J. Wiedermann, Enzo Bonora, Friedrich Oberhollenzer, Michele Muggeo, Qingbo Xu, Georg Wick, Werner Poewe, Johann Willeit
Journal: Circulation (2001)

Chronic infections have been implicated in the pathogenesis of atherosclerosis, yet from an epidemiological perspective, this concept remains controversial.The Bruneck Study is a prospective population-based survey on the pathogenesis of atherosclerosis. In 826 men and women 40 to 79 years old (1990 baseline), 5-year changes in carotid atherosclerosis were thoroughly assessed by high-resolution duplex scanning. The presence of chronic respiratory, urinary tract, dental, and other infections was ascertained by standard diagnostic criteria. Chronic infections amplified the risk of atherosclerosis development in the carotid arteries. The association was most pronounced in subjects free of carotid atherosclerosis at baseline (age-/sex-adjusted odds ratio [95% CI] for any chronic infection versus none, 4.08 [2.42 to 6.85]; P:<0.0001) and applied to all types of chronic (bacterial) infections. It remained independently significant after adjustment for classic vascular risk attributes and extended to low-risk individuals free of conventional risk factors. Among subjects with chronic infections, atherosclerosis risk was highest in those with a prominent inflammatory response. Markers of systemic inflammation, such as soluble adhesion molecules and circulating bacterial endotoxin, and levels of soluble human heat-shock protein 60 and antibodies to mycobacterial heat-shock protein 65 were elevated in subjects with chronic infections and predictive of an increased risk of atherosclerosis.The present study provides solid evidence for a role of common chronic infections in human atherogenesis. Induction of systemic inflammation and autoimmunity may be potential pathophysiological links.
Fever of Unknown Origin
Authors: Donald M. Vickery
Journal: JAMA (1977)

FEVER of unknown origin (FUO) has been regarded as a supreme diagnostic puzzle. This reputation may be undeserved, since there is a tendency to group under this heading many specific syndromes that include fever as one of their symptoms. The term "FUO" should be reserved for a syndrome in which the fever is prolonged and there are no other specific signs or symptoms that would define a separate syndrome. The first criterion is recognized generally, but neglect of the second has resulted in the implication that fevers associated with polyarthritis, abdominal pain, or rash are all FUOs and may be approached similarly. A third criterion, that the fever is undiagnosed after routine diagnostic tests, is sometimes applied but is too vague to be satisfactory. The algorithms presented here provide a logical, step-by-step approach to the FUO syndrome. The essential features of this approach are (1) limitation of associated symptoms to
Modifiable barriers to adherence to inhaled steroids among adults with asthma: It's not just black and white
Authors: Andrea J. Apter, Ray C. Boston, Maureen George, A.Lorraine Norfleet, Thomas Tenhave, James C. Coyne, Kathleen Birck, Susan T. Reisine, Andrew J. Cucchiara, Harold I. Feldman
Journal: Journal of Allergy and Clinical Immunology (2003)
A Unique Subset of Epithelial Ovarian Cancers with Platinum Sensitivity and PARP Inhibitor Resistance
Authors: Raphael Ceccaldi, Kevin W. O'Connor, Kent W. Mouw, Adam Y. Li, Ursula A. Matulonis, Alan D. D'Andrea, Panagiotis A. Konstantinopoulos
Journal: Cancer Research (2015)

Platinum and PARP inhibitor (PARPi) sensitivity commonly coexist in epithelial ovarian cancer (EOC) due to the high prevalence of alterations in the homologous recombination (HR) DNA repair pathway that confer sensitivity to both drugs. In this report, we describe a unique subset of EOC with alterations in another DNA repair pathway, the nucleotide excision repair (NER) pathway, which may exhibit a discordance in sensitivities to these drugs. Specifically, 8% of high-grade serous EOC from The Cancer Genome Atlas dataset exhibited NER alterations, including nonsynonymous or splice site mutations and homozygous deletions of NER genes. Tumors with NER alterations were associated with improved overall survival (OS) and progression-free survival (PFS), compared with patients without NER alterations or BRCA1/2 mutations. Furthermore, patients with tumors with NER alterations had similar OS and PFS as BRCA1/2-mutated patients, suggesting that NER pathway inactivation in EOC conferred enhanced platinum sensitivity, similar to BRCA1/2-mutated tumors. Moreover, two NER mutations (ERCC6-Q524* and ERCC4-A583T), identified in the two most platinum-sensitive tumors, were functionally associated with platinum sensitivity in vitro. Importantly, neither NER alteration affected HR or conferred sensitivity to PARPi or other double-strand break-inducing agents. Overall, our findings reveal a new mechanism of platinum sensitivity in EOC that, unlike defective HR, may lead to a discordance in sensitivity to platinum and PARPi, with potential implications for previously reported and ongoing PARPi trials in this disease.
Direct measurement of hepatic indocyanine green clearance with near-infrared spectroscopy: Separate evaluation of uptake and removal
Authors: H Shinohara, A Tanaka, T Kitai, N Yanabu, T Inomoto, S Satoh, E Hatano, Y Yamaoka, K Hirao
Journal: Hepatology (1996)

We continuously measured hepatic absorbance of indocyanine green (ICG) using near-infrared (NIR) spectroscopy after intravenous bolus injection in rabbits. Hepatic ICG concentration was obtained by subtracting out the absorbance of hemoglobin and other pigments within the liver. Two exponential rate constants, the first reflecting the dye uptake from plasma to the hepatocytes, and the second representing the dye removal from the liver by cytoplasmic transport and biliary excretion, were determined by fitting the time-course curve of hepatic ICG concentration to a two-compartment model with irreversible transfer between the two compartments, as defined by the double-exponential equation: [ICG]liver(t) = -A exp(-alpha t) + B exp(-beta t). The results showed that treatment with bilirubin, a competitive inhibitor of ICG uptake, caused a decrease in alpha. Treatment with either colchicine, which is toxic to microtubules, or with ouabain, an inhibitor of Na+,K(+)-ATPase, caused a decrease in beta. These results were compatible with the kinetic model. This new method was then used in liver-injured rabbits inflicted with hemorrhagic shock and ischemia-reperfusion, to show that the first rate constant is primarily affected by hepatic microcirculatory condition, and the second refers closely to parenchymal liver damage. In another series of partial liver ischemia-reperfusions, it was possible to simultaneously and separately monitor the ICG profiles of post-ischemic and nonischemic areas. Thus, the kinetic analysis of hepatic ICG concentration curves, as directly measured by NIR spectroscopy, led to the separate evaluation of different clearance process of ICG in the liver, suggesting the advanced utility as a comprehensive liver function test.
Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C
Authors: Pierre-Yves Bochud, Tao Cai, Kathrin Overbeck, Murielle Bochud, Jean-François Dufour, Beat Müllhaupt, Jan Borovicka, Markus Heim, Darius Moradpour, Andreas Cerny, Raffaele Malinverni, Patrick Francioli, Francesco Negro
Journal: Journal of Hepatology (2009)
Mechanisms of lymphocyte adhesion to human vascular endothelial cells in culture. T lymphocyte adhesion to endothelial cells through endothelial HLA-DR antigens induced by gamma interferon.
Authors: J Masuyama, N Minato, S Kano
Journal: Journal of Clinical Investigation (1986)

The effects of interferons (IFNs) on lymphocyte adhesion to cultured human vascular endothelial cells (EC) were investigated using an in vitro assay. Endothelial cells obtained from umbilical vein were first cultured at a low density with a conditioned medium (CM) from 12-O-tetra decanoylphorbol 13-acetate-concanavalin A (TPA-Con A) stimulated human peripheral blood lymphocytes (PBL), or with recombinant (r) gamma interferon (IFN-gamma) or r alpha interferon (IFN-alpha), and then were incubated with freshly isolated PBL. Natural IFN-gamma in the TPA-Con A CM and rIFN-gamma (12.5-500 U/ml) induced major histocompatibility complex-class II antigens (HLA-DR, HLA-DP, and HLA-DQ) and significant lymphocyte adhesion to the EC, whereas rIFN-alpha did not. The lymphocyte adhesion to the EC and the expression of DR antigens on the EC were well correlated in terms of both kinetics and the dose-response pattern of rIFN-gamma. When EC expressing I region associated (Ia) antigen were preincubated with monoclonal anti-DR antibody before the addition of lymphocytes, the lymphocyte adhesion was significantly inhibited in both allogeneic and syngeneic combinations, whereas anti-HLA-DP, anti-HLA-DQ, and anti-HLA-ABC antibodies did not inhibit the binding at all. Cell fractionation experiments indicated that the majority of lymphocytes adhering to Ia-expressed EC were Leu-3+ T cells, whose binding was again almost completely inhibited by anti-DR antibody. Moreover, anti-Leu-3a, but not anti-Leu-2a, antibody effectively inhibited the T cell adhesion to the EC. These results strongly suggest that the interaction of the Leu-3(T4) receptor of T cells with IFN-gamma-induced DR antigens on EC plays a central role in the selective adhesion of Leu-3+ T cell to EC.
P3-07-31: Intra-Operative Assessment of Sentinel Lymph Nodes in Breast Cancer with Touch Imprint Cytology (TIC) in 460 Consecutive Patients.
Authors: M Iqbal, G Shetty, S Randhawa, F Sandhu, N Chachlani, J Simon, S Harries, L Jones, D Clarke
Journal: Cancer Research (2011)

Abstract Background Sentinel node biopsy (SNB) accurately predicts the axillary lymph node status in patients with breast cancer. The sentinel lymph node (SLN) is evaluated by routine histology, requiring 3–5 days for the results and a second operation if the SLN is positive. However a second operation can be avoided if a reliable intraoperative assessment of the SLN was available. The techniques used for intra-operative assessment of the SLN include frozen section, touch imprint cytology (TIC) and more recently molecular biology assays. The aim of this study was to evaluate the accuracy of TIC in the assessment of the SLN. Methods: A prospective study to include 460 patients with breast cancer who underwent SNB and had the sentinel node assessed intra-operatively with TIC. The SLN was bisected and a touch imprint was made on to a slide. The imprint was stained with Giemsa stain. Permanent sections were evaluated with H&amp;E and immunohistochemical staining. The TIC results were compared with the final histology of the SLN. Results: 766 SLN's were harvested from 460 patients (Mean - 1.66). Of the 460 patients, TIC was falsely negative in 50(24%) patients. No patients had false positive results. Negative predictive value was 87%. The accuracy rate was 89%. 94 patients were positive on histology. TIC was positive in 44 patients and negative in 50. The sensitivity, specificity and positive predictive value of TIC was 47%, 100% and 100% respectively. By acting on the results of TIC, 44 patients (47%) had an axillary clearance at the primary operation and were thus spared a second operation. Conclusion: TIC in our cohort of 460 patients and 766 sentinel lymph nodes had an accuracy rate of 89% and specificity of 100%. Our study compares favourably with published literature, confirming that TIC is a simple, quick, reliable and reproducible technique that can be used for intra operative assessment of the SLN. A sensitivity of 47% means that about half of the SLN positive patients were spared a second operation. We had hoped that with more experience, our sensitivity would improve but since this has not been the case we are now moving towards molecular biology assays (OSNA) to assess the SN intra-operatively. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-07-31.
Right heart function during left heart assist and the effects of volume loading in a canine preparation.
Authors: D J Farrar, P G Compton, H Dajee, J D Fonger, J D Hill
Journal: Circulation (1984)

A significant fraction of patients in whom mechanical left ventricular assist devices are implanted for refractory cardiac failure after open heart surgery have had the complication of right heart failure. To evaluate the effects of left ventricular assistance and pressure unloading on right ventricular function, we performed experiments in the normal hearts of open-chest, anesthetized, large mongrel dogs. We compared right ventricular function before and after left ventricular-to-aortic bypass with a roller pump at right atrial pressure levels of 1, 3, 5, and 7 mm Hg produced by volume loading. No significant changes were found in cardiac output or stroke volume over this range of right atrial pressures when comparing that before to that during left ventricular bypass, which at a right atrial pressure of 1 mm Hg reduced peak left ventricular pressure from 96 +/- 6 to 15 +/- 9 mm Hg and at a right atrial pressure of 5 mm Hg reduced it from 113 +/- 3 to 29 +/- 12 mm Hg, while maintaining aortic pressure. There was no evidence of right ventricular failure under these conditions: (from before to during bypass) at a right atrial pressure of 1 mm Hg cardiac output was 3.4 +/- 0.4 to 3.7 +/- 0.6 liter/min and stroke volume was 28 +/- 5 to 33 +/- 6 ml; during volume loading at a right atrial pressure of 7 mm Hg cardiac output was 5.6 +/- 0.6 to 5.7 +/- 0.7 liter/min and stroke volume was 47 +/- 5 to 52 +/- 5 ml.(ABSTRACT TRUNCATED AT 250 WORDS)
Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway.
Authors: J S Koh, W Lieberthal, S Heydrick, J S Levine
Journal: Journal of Clinical Investigation (1998)

Lysophosphatidic acid (LPA) is the smallest and structurally simplest of all the glycerophospholipids. It occurs normally in serum and binds with high affinity to albumin, while retaining its biological activity. The effects of LPA are pleiotropic and range from mitogenesis to stress fiber formation. We show a novel role for LPA: as a macrophage survival factor with potency equivalent to serum. Administration of LPA protects macrophages from apoptosis induced by serum deprivation, and protection is equivalent to that with conventional survival factors such as macrophage colony stimulating factor. The ability of LPA to act as a survival factor is mediated by the lipid kinase phosphatidylinositol 3-kinase (PI3K), since LPA activated both the p85-p110 and p110gamma isoforms of PI3K and macrophage survival was blocked completely by wortmannin or LY294002, two mechanistically dissimilar inhibitors of PI3K. pp70(s6k), a downstream kinase activated by PI3K, also contributes to survival, because inhibitors of pp70(s6k), such as rapamycin, blocked macrophage survival in the presence of LPA. Modified forms of LPA and phospholipids, such as phosphatidylcholine and phosphatidylethanolamine, had no survival effect, thereby showing the specificity of LPA. These results show that LPA acts as a potent macrophage survival factor. Based on striking similarities between our LPA and serum data, we suggest that LPA is a major noncytokine survival factor in serum.
THE SPECIFICITY OF OXIDIZED AND REDUCED PROTEINS OF THE OCULAR LENS
Authors: E. E. Ecker, L. Pillemer
Journal: The Journal of Experimental Medicine (1940)

Oxidized and reduced proteins were prepared from the ocular lenses of sheep, swine, chicken and fish (pike). The proteins were prepared under conditions designed to avoid denaturation and to produce relatively pure compounds. Serologic studies revealed that species specificity is demonstrable in the proteins from chicken and fish lenses, but in the more closely related species (swine and sheep) this characteristic is not so evident. Serologic differences may be detected in the lens preparations from a single species, depending on the redox state of the protein.
Consensus on cancer therapy.
Authors: D. Newling
Journal: BMJ (1988)

due to various compounds such as barbiturates, organophosphates, and antihistamines'.Like Dr D G Menezies and his colleagues, we had to face the problem of pulmonary aspiration of the charcoal (13 August, p 459); three of our patients developed this complication and died, despite the prior administration of parenteral metoclopramide and ranitidine.To overcome this problem in the next six patients with reduced consciousness we passed a cuffed endotracheal tube before starting treatment with charcoal.The endotracheal tube was retained for the next 48 hours, and since then we have not encountered a problem with aspiration.
Disruption of theArnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice
Authors: Sun Hee Yim, Yatrik Shah, Shuhei Tomita, Douglas H. Morris, Oksana Gavrilova, Gilles Lambert, Jerrold M. Ward, Frank J. Gonzalez
Journal: Hepatology (2006)

Vascular endothelial cells (ECs) play a critical role in angiogenesis and organogenesis, especially in embryonic liver development. Hypoxia-inducible transcription factors (Hifs) are a key trigger of hypoxic signals, a primary stimulus of angiogenesis. The aryl hydrocarbon receptor nuclear translocator (Arnt), also called Hif-1β, serves as an obligate heterodimerization partner of Hif-1α and Hif-2α. Using Cre-Lox technology, the mouse Arnt gene was specifically disrupted in endothelial cells. The resulting mice, designated ArntΔEC, developed impaired hepatic vasculature, liver necrosis, and degenerative lesions in cardiac myocytes at the late embryonic stage (E16.5-E18.5), leading to approximately 90% neonatal lethality. Low serum glucose, downregulation of glucose transporter-1 and glucose-6-phosphatase mRNA, and hepatocyte proliferation were observed in ArntΔEC embryos. Magnetic resonance imaging on E16.5 embryonic livers revealed that ArntΔEC mice had a significant volume of avascular region. ArntΔEC mice that survived to the adult stage were fertile, showed normal behavioral activity, but had smaller livers with mild portal fibrosis, dilated blood vessels, abnormal collagen accumulation, and remarkable iron deposition. ArntΔEC mice had reduced adiposity, impaired serum lipid homeostasis, and a higher respiratory exchange ratio, indicating they utilized relatively more carbohydrates than their ArntF/F counterparts. In conclusion , endothelial Arnt plays a pivotal role in embryonic liver development. Adult ArntΔEC mice carrying embryonic hepatic defects developed what was possibly an early stage of cirrhosis with consequences of limited oxygen availability and altered lipid metabolism.
Sulfadoxine-pyrimethamine for uncomplicated falciparum malaria: Treatment failure and resistance in Malawi remain subject for debate
Authors: P Ringwald
Journal: BMJ (2004)

EDITOR—The methods applied to enhance the interpretation of the data by Plowe et al deserve comment.1

The World Health Organization has developed several standardised protocols to assess the efficacy of antimalarial drugs, which are intended to determine treatment failures and not resistance patterns of the parasite. Recently, WHO published a revised protocol, giving clear indications of outcome classifications and the target groups (children under 5 years …
Extensive Xanthomas and Severe Subclinical Atherosclerosis in Homozygous Familial Hypercholesterolemia
Authors: Viviane Z. Rocha, Ana P.M. Chacra, Wilson Salgado, Marcio Miname, Luciana Turolla, Ana C.M. Gagliardi, Expedito E. Ribeiro, Ricardo P.S. Rocha, Luiz F.R. Avila, Alexandre Pereira, Edna R. Nakandakare, Raul D. Santos
Journal: Journal of the American College of Cardiology (2013)
Arsenic, Organic Foods, and Brown Rice Syrup
Authors: Brian P. Jackson, Vivien F. Taylor, Margaret R. Karagas, Tracy Punshon, Kathryn L. Cottingham
Journal: Environmental Health Perspectives (2012)

Rice can be a major source of inorganic arsenic (Asi) for many sub-populations. Rice products are also used as ingredients in prepared foods, some of which may not be obviously rice based. Organic brown rice syrup (OBRS) is used as a sweetener in organic food products as an alternative to high-fructose corn syrup. We hypothesized that OBRS introduces As into these products.We determined the concentration and speciation of As in commercially available brown rice syrups and in products containing OBRS, including toddler formula, cereal/energy bars, and high-energy foods used by endurance athletes.We used inductively coupled plasma mass spectrometry (ICP-MS) and ion chromatography coupled to ICP-MS to determine total As (Astotal) concentrations and As speciation in products purchased via the Internet or in stores in the Hanover, New Hampshire, area.We found that OBRS can contain high concentrations of Asi and dimethyl-arsenate (DMA). An "organic" toddler milk formula containing OBRS as the primary ingredient had Astotal concentrations up to six times the U.S. Environmental Protection Agency safe drinking water limit. Cereal bars and high-energy foods containing OBRS also had higher As concentrations than equivalent products that did not contain OBRS. Asi was the main As species in most food products tested in this study.There are currently no U.S. regulations applicable to As in food, but our findings suggest that the OBRS products we evaluated may introduce significant concentrations of Asi into an individual's diet. Thus, we conclude that there is an urgent need for regulatory limits on As in food.