tbuckley/cabot-search huggingface dataset:
Abstract 4864: Aroma terpenes prevent UVB-induced sunburn in Skh1 mouse skin.
Authors: Ahmed N. Uddin, Ivica Labuda, Feng Wu, KamMeng Tchou-Wong, Fredric J. Burns
Journal: Cancer Research (2013)

Abstract Understanding how aroma terpenes prevent sunburn and/or skin cancer in mice could lead to more effective and safer ways of blocking sun damage to human skin. In our previous study, β-damascenone, an aroma terpene, protected against sunburn by activating both keratinocyte and sebaceous gland pathways that fortified and thickened the cornified envelope and sebum layers of mouse epidermis. In the current study, the sunburn preventive activity of d-limonene was examined to confirm that these related compounds work similarly. In addition to sunburn, immunohistochemical analyses of proliferation (PCNA) and a damage-response gene N-Myc Down Regulated Gene 1 (NDRG1) were investigated in control versus d-limonene-treated Skh-1 mice. The mice were treated either topically on the dorsum or orally with different concentrations of d-limonene in liponate (100%, 10%, 1% and 0%) followed by exposure of the dorsum to solar simulation ultraviolet radiation (UVR) of 1.5 kJ/m2 from fluorescent ‘sunlamps’. Either 4 topical 5 μL doses or a single dose of 20 μL (0.95 μg/g body weight) of 100% d-limonene provided complete protection from UVR-induced sunburn. The protection was less but still significant at 10% d-limonene but was absent at 1% d-limonene in comparison to UVR alone. PCNA-labeling showed a marked proliferation increase of epidermal basal cells, outer root sheath cells of hair follicles and sebaceous gland cells by separate exposures to d-limonene and UVR relative to controls. The combined treatment of d-limonene followed by UVR produced fewer PCNA-positive cells in epithelial tissue relative to UVR-only mice. The NDRG1 protein (an indirect measure of DNA damage) was overwhelmingly (∼85% of keratinocytes) induced by UVR indicating heavy DNA damage. The UVR-induced NDRG1 index remained at ∼85% at 1% d -limonene, but was significantly reduced at 10% d-limonene to ∼24% and to less than 1% at 100% d -limonene indicating nearly complete elimination of cellular damage as a pure compound; a finding that is consistent with complete sunburn prevention. The thickness of the cornified envelope plus sebum layers nearly doubled within 5 days after administration of the d-limonene corresponding to the time of UVR application. Overall the results indicate that d-limonene protected against sunburn by activating keratinocyte/sebaceous gland-based pathways that fortified and thickened the cornified envelope plus sebum layers on the skin surface by releasing elevated levels of UVR-absorbing proteins that decreased UVR dose to underlying cutaneous tissues. Citation Format: Ahmed N. Uddin, Ivica Labuda, Feng Wu, KamMeng Tchou-Wong, Fredric J. Burns. Aroma terpenes prevent UVB-induced sunburn in Skh1 mouse skin. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4864. doi:10.1158/1538-7445.AM2013-4864
In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor
Authors: Magdalena H. Menhofer, Dominik Bartel, Johanna Liebl, Rebekka Kubisch, Johanna Busse, Ernst Wagner, Rolf Müller, Angelika M. Vollmar, Stefan Zahler
Journal: Cardiovascular Research (2014)

AimsInhibiting angiogenesis is a major approach in tumour therapy. To combat angiogenesis, the tubulin cytoskeleton has emerged as an interesting target in many pre- and clinical studies. Contrarily, the actin cytoskeleton has been largely neglected as a potential drug target in angiogenesis. However, due to the development of drug resistances, new therapeutic strategies are always needed in tumour treatment. Therefore, the therapeutic potential of actin-binding small molecules is of particular interest.
The Pathology of Hepatic Iron Overload: A Free Radical–Mediated Process?
Authors: Bruce R. Bacon, Robert S. Britton
Journal: Hepatology (1990)

HepatologyVolume 11, Issue 1 p. 127-137 Special ArticleFree Access The pathology of hepatic iron overload: A free radical-Mediated Process? Bruce R. Bacon, Corresponding Author Bruce R. Bacon Section of Gastroenterology and Hepatology, Department of Medicine, Louisiana State University School of Medicine, Shreveport, Louisiana 71130–3932Section of Gastroenterology and Hepatology, Louisiana State University School of Medicine, 1501 Kings Highway, Shreveport, Louisiana 71130–3932===Search for more papers by this authorRobert S. Britton, Robert S. Britton Section of Gastroenterology and Hepatology, Department of Medicine, Louisiana State University School of Medicine, Shreveport, Louisiana 71130–3932Search for more papers by this author Bruce R. Bacon, Corresponding Author Bruce R. Bacon Section of Gastroenterology and Hepatology, Department of Medicine, Louisiana State University School of Medicine, Shreveport, Louisiana 71130–3932Section of Gastroenterology and Hepatology, Louisiana State University School of Medicine, 1501 Kings Highway, Shreveport, Louisiana 71130–3932===Search for more papers by this authorRobert S. Britton, Robert S. Britton Section of Gastroenterology and Hepatology, Department of Medicine, Louisiana State University School of Medicine, Shreveport, Louisiana 71130–3932Search for more papers by this author First published: January 1990 https://doi.org/10.1002/hep.1840110122Citations: 284AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume11, Issue1January 1990Pages 127-137 ReferencesRelatedInformation
Functional redundancy of PI3K isoforms in conventional T cells provides a selective Treg-targeting strategy through inhibition of PI3K-delta isoform
Authors: Shamim Ahmad, Mikayel Mkrtichyan, Rasha Abu Eid, Rajeev Shrimali, Atbin Doroodchi, Samir N Khleif
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Increased regulatory T cell (Treg) numbers within tumors and circulation of cancer patients, observed in early studies, implied their involvement in pathogenesis and disease progression. Also, Treg increase in cancer patients have been associated with reduced survival and
Asiatic Schistosomiasis
Authors: Lyman O. Warren
Journal: New England Journal of Medicine (1947)

THE following case of acute Asiatic schistosomiasis was unique in that an opportunity was afforded to follow the clinical course with repeated sigmoidoscopies and serial roentgenograms from the onset of symptoms to the termination of a course of treatment — a period of sixty days. More informative accounts of the disease are given by Billings, Winkenwerder and Hunninen,1 Thomas and Gage,2 Faust et al.3 and others.4 A 19-year-old soldier of Italian descent was admitted to the 117th Station Hospital on Leyte, Philippine Islands, on December 19, 1945, with a chief complaint of "hives." He stated that about 30 days previously . . .
Diagnosis of autosomal recessive lamellar ichthyosis with mutations in the TGM1 gene
Authors: P.B. Cserhalmi-Friedman, L.M. Milstone, A.M. Christiano
Journal: British Journal of Dermatology (2001)

Autosomal recessive lamellar ichthyosis (ARLI) is a clinically and genetically heterogeneous disorder. In many cases, mutations in the transglutaminase 1 gene (TGM1) have been identified, however, other clinically indistinguishable cases have been linked to chromosomes 2, 3 and 19. Previous studies have failed to establish any correlation between clinical characteristics and genetic mutations.To investigate the molecular basis of ARLI in 10 patients with the typical clinical presentation of the disorder.We performed polymerase chain reaction and direct sequencing-based mutation screening in all of these patients, and TGM1 immunofluorescence microscopy and in vitro enzyme activity assays in selected patients.Mutation screening revealed 14 mutations, four of which have been previously described. While immunofluorescence microscopy was negative in patients with non-sense mutations or out-of-frame insertions or deletions, the results were variable in cases with mis-sense mutations and in cases with no mutations in the TGM1 gene. In vitro enzyme activity assays gave results consistent with the mutation data.Our findings support the importance of mutation screening in the evaluation of ARLI.
Polyvariant mutant cystic fibrosis transmembrane conductance regulator genes. The polymorphic (Tg)m locus explains the partial penetrance of the T5 polymorphism as a disease mutation.
Authors: H Cuppens, W Lin, M Jaspers, B Costes, H Teng, A Vankeerberghen, M Jorissen, G Droogmans, I Reynaert, M Goossens, B Nilius, J J Cassiman
Journal: Journal of Clinical Investigation (1998)

In congenital bilateral absence of the vas deferens patients, the T5 allele at the polymorphic Tn locus in the CFTR (cystic fibrosis transmembrane conductance regulator) gene is a frequent disease mutation with incomplete penetrance. This T5 allele will result in a high proportion of CFTR transcripts that lack exon 9, whose translation products will not contribute to apical chloride channel activity. Besides the polymorphic Tn locus, more than 120 polymorphisms have been described in the CFTR gene. We hypothesized that the combination of particular alleles at several polymorphic loci might result in less functional or even insufficient CFTR protein. Analysis of three polymorphic loci with frequent alleles in the general population showed that, in addition to the known effect of the Tn locus, the quantity and quality of CFTR transcripts and/or proteins was affected by two other polymorphic loci: (TG)m and M470V. On a T7 background, the (TG)11 allele gave a 2.8-fold increase in the proportion of CFTR transcripts that lacked exon 9, and (TG)12 gave a sixfold increase, compared with the (TG)10 allele. T5 CFTR genes derived from patients were found to carry a high number of TG repeats, while T5 CFTR genes derived from healthy CF fathers harbored a low number of TG repeats. Moreover, it was found that M470 CFTR proteins matured more slowly, and that they had a 1.7-fold increased intrinsic chloride channel activity compared with V470 CFTR proteins, suggesting that the M470V locus might also play a role in the partial penetrance of T5 as a disease mutation. Such polyvariant mutant genes could explain why apparently normal CFTR genes cause disease. Moreover, they might be responsible for variation in the phenotypic expression of CFTR mutations, and be of relevance in other genetic diseases.
Pernicious anaemia and Campylobacter like organisms; is the gastric antrum resistant to colonisation?
Authors: J F Flejou, P Bahame, A C Smith, R W Stockbrugger, J Rode, A B Price
Journal: Gut (1989)

Gastric biopsies from 86 patients with pernicious anaemia were examined for Campylobacter like organisms with particular attention to those showing an antral gastritis in addition to the usual pattern of body gastritis. All the patients had chronic atrophic gastritis in the body but Campylobacter like organisms were found at this site in only three patients. Thus the Type A pattern of gastritis (autoimmune) seen in patients with pernicious anaemia is only rarely associated with Campylobacter like organisms. Forty four of these patients had biopsies from body and antrum, 16 showed an antral gastritis of whom only one had Campylobacter like organism present. Twenty five of this latter group of patients were rebiopsied after five years. There was no change in the pattern of gastritis, and the same single patient remained colonised. The frequency of an antral gastritis in patients with pernicious anaemia was 36% yet the frequency of antral colonisation by Campylobacter like organisms was very low (6%). These results show that, as in the body, Campylobacter like organisms are not associated with gastritis when it occurs at this site in pernicious anaemia. The antral gastritis that may accompany body gastritis in pernicious anaemia seems more likely therefore to be an extension of primary type A body gastritis (autoimmune) rather than a secondary type B (chronic) gastritis and, it is argued, the antrum may exhibit resistance to colonisation.
The Flowers Report and the Institute of Dermatology
Authors: A. Lyell
Journal: BMJ (1980)

activity (p 29; Fox et al2), a finding not con- sistent with-the data of McClusky's et al.3 Thus there is no consensus regarding the relationship between the presence or absence of HLA-B27 and disease severity in Reiter's syndrome.This is an important issue since it would appear that knowledge of HLA status does not provide the physician with useful prognostic information, a topic discussed more fully elsewhere.'
Pseudohypoparathyroidism: defective excretion of 3′,5′-AMP in response to parathyroid hormone
Authors: Lewis R. Chase, G. Leland Melson, G. D. Aurbach
Journal: Journal of Clinical Investigation (1969)

Urinary excretion of cyclic adenosine 3',5'-monophosphate (3',5'-AMP) was tested in normal subjects and patients with pseudohypoparathyroidism, idiopathic hypoparathyroidism, surgical hypoparathyroidism, and pseudopseudohypoparathyroidism under basal conditions and after a 15 min infusion of purified parathyroid hormone. Basal excretion of the nucleotide was less than normal in the patients with hypocalcemic disorders and greater than normal in pseudopseudohypoparathyroidism. Parathyroid hormone caused a marked increase in excretion of 3',5'-AMP in all subjects except those with pseudohypoparathyroidism; nine patients with this disorder did not respond to the hormone and four showed a markedly deficient response. Radioimmunoassay showed that parathyroid hormone circulated in increased amounts in plasma from patients with pseudohypoparathyroidism and became undetectable when serum calcium was increased above 12 mg/100 ml. Suppression of parathyroid hormone secretion by induction of hypercalcemia did not alter the deficient response to exogenous hormone. The results indicate that: (a) parathyroid hormone circulates in abnormally high concentrations in pseudohypoparathyroidism and secretion of the hormone responds normally to physiological control by calcium; (b) testing urinary excretion of 3',5'-AMP in response to infusion of purified parathyroid hormone appears to be an accurate and sensitive index for establishing the diagnosis of pseudohypoparathyroidism; and (c) the metabolic defect of the disorder can be accounted for by a lack of or defective form of parathyroid hormone-sensitive adenyl cyclase in bone and kidney.
Endoscopic retrograde cholangiopancreatography. Diagnosis of cholelithiasis in patients with normal gallbladder x-ray and ultrasound studies
Authors: R. P. Venu
Journal: JAMA (1983)

The combination of a normal oral cholecystogram and ultrasound study of the gallbladder is considered adequate evidence to exclude cholelithiasis as a cause of biliarylike pain. We examined 206 patients with biliarylike pain and normal findings on cholecystogram and ultrasound study of the gallbladder by endoscopic retrograde cholangiopancreatography (ERCP). Of the 195 patients who had successful ERCP, 32 patients (group 1) had mild, transient abnormalities in liver function tests and 163 (group 2) had normal liver function test results. Small gallstones were demonstrated on ERCP examination in 25 of 32 group 1 patients and in four of 163 group 2 patients, all confirmed at surgery or endoscopic sphincterotomy. In conclusion, despite negative results on cholecystogram and ultrasound study of the gallbladder, patients with biliarylike pain and abnormal liver function test results should be evaluated further by diagnostic ERCP examination. (<i>JAMA</i>1983;249:758-761)
A prospective cohort study of incident maintenance dialysis in children: An NAPRTC study11The North American Pediatric Renal Transplant Cooperative Study (NAPRTCS) is a voluntary collaborative effort comprising over 150 pediatric renal disease treatment centers in the United States, Canada, Mexico and Costa Rica. It is supported by major, unrestricted educational grants from Novartis, AMGEN, and Genentech. Participating NAPRTCS Centers are listed in the most recent NAPRTCS Annual Report […
Authors: Mary B. Leonard, Lynn A. Donaldson, Martin Ho, Denis F. Geary
Journal: Kidney International (2003)
Temporary Intestinal Occlusion Induced by a ”Patency Capsule” in a Patient with Crohn’s Disease
Authors: G. Gay, M. Delvaux, V. Laurent, N. Reibel, D. Regent, G. Grosdidier, J.-F. Roche
Journal: Endoscopy (2005)

A 26-year-old woman was admitted for the investigation of abdominal symptoms related to ileal Crohn's disease. The patient had been diagnosed 3 years previously with systemic sclerosis, and had been experiencing digestive complaints for 6 months. A first computed tomography (CT) scan showed ileal intestinal mucosal alterations, associated with a sclerolipomatosis and suspicion of ileal stenosis. An ileocolonoscopy was then performed and showed ulcers in the terminal ileum with nonspecific inflammatory changes found on biopsies, both suggesting the diagnosis of Crohn's disease. The patient was admitted for M2A capsule endoscopy, in order to clarify the respective roles of systemic sclerosis and Crohn's disease with regard to the symptoms and secondarily to determine the anatomical extent of the Crohn's lesions. A patency capsule was administered, for detection of intestinal stenosis before capsule endoscopy was done. At 30 hours after capsule ingestion, the patient complained of abdominal pain and nausea and experienced intestinal obstruction due to the blockage of the patency capsule in the ileal stenosis. The capsule dissolved after 76 hours and the patient then improved. After a few days, the patient underwent ileocecal resection. Pathological examination of the surgical specimen confirmed the presence of an ileal stenosis 17 cm in length. In some circumstances a patency capsule may dissolve slowly, leading to transitory intestinal obstruction requiring medical intervention. It should thus be used cautiously under clinical surveillance in patients with Crohn's disease.
FALLING DROP METHOD FOR SPECIFIC GRAVITY
Authors: William F. Hamilton
Journal: JAMA (1942)

<h3>To the Editor:—</h3> In recent years much interest has developed in the clinical applications of the falling drop method for specific gravity, the chief of which were first pointed out by us inThe Journal, Jan. 8, 1927, page 91. Their usefulness has been recognized in large measure because of the notable studies of shock by Dr. John Scudder. Clinical interest in the densiometric method has led to the appearance in the literature of a considerable number of so-called "improvements." Modifications of the method, deriving from various sources, are leading to its abuse by the employment of procedures which detract from its sensitivity. Alluring suggestions, such as "elimination of standards and nomograms," militate against the accuracy of the method. Standard drops of pure potassium sulfate solutions are of constant composition and eliminate the vagaries due to the use of oils as the medium through which the drops fall. Vagaries occur
Cinema smoking encourages the habit in adolescents
Authors: A Rajasekaran
Journal: Thorax (2003)

▴ Dalton MA, Sargent JD, Beach ML, et al . Viewing smoking in movies positively influences smoking initiation among adolescents. Lancet2003;362:4999 [OpenUrl][1] Many studies have linked tobacco marketing with an increased uptake of smoking in adolescents. In this longitudinal study 3547 students aged 10–14 years who attended schools in Vermont and New Hampshire, USA and who had never smoked previously were assessed for exposure to smoking in cinemas. Fifty movies were randomly … [1]: {openurl}?query=rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx
Cost-effectiveness analysis of a disease management program in chronic heart failure: DIAL trial-- G.E.S.I.C.A. investigators
Authors: Hugo O. Grancelli, Carola Zambrano, Ricardo D. Dran, Silvina Ramos, Saul Soifer, Armando Buso, Daniel Ferrante, Sergio Varini, Daniel Nul, Hernan C. Doval
Journal: Journal of the American College of Cardiology (2003)
The Epidemiology of the Gastrointestinal Randomized Clinical Trial
Authors: Erik Juhl, Erik Christensen, Niels Tygstrup
Journal: New England Journal of Medicine (1977)

Abstract Has the randomized clinical trial (RCT), generally accepted as the method of choice for evaluation of most treatments, obtained a footing in gastroenterology? Among 35,228 citations on gastroenterologic therapy indexed in MEDLARS 1964–1974 306 (0.9 per cent) were RCT's. During the decade their frequency rose significantly (P<0.05) from 0.3 per cent in 1964 to 1.7 per cent in 1973. The "typical" RCT was a double-blind two-group comparison of a new and an established drug on the symptoms of peptic ulcer; 50 patients were followed for six weeks, and the number of dropouts was unknown. The new drug was found to be more effective. It is postulated that the RCT's in gastroenterology are quantitatively and qualitatively insufficient and that co-ordinated planning of RCT's and uninhibited publication of statistically proved negative results may help to ensure that the patient with gastrointestinal disease receives the best available treatment. (N Engl J Med 296:20–22, 1977
IFN-Producing Killer Dendritic Cells Are Antigen-Presenting Cells Endowed with T-Cell Cross-Priming Capacity
Authors: Maria Pletneva, Hongni Fan, Jang-June Park, Vedran Radojcic, Chunfa Jie, Yanxing Yu, Camie Chan, Alec Redwood, Drew Pardoll, Franck Housseau
Journal: Cancer Research (2009)

Abstract IFN-producing killer dendritic cells (IKDC) represent a recently discovered cell type in the immune system that possesses a number of functions contributing to innate and adaptive immunity, including production of type 1 and 2 IFNs, interleukin (IL)-12, natural killing, and ultimately antigen presentation to naïve T cells. Here, we compared in vitro and in vivo responses of mouse IKDC, conventional dendritic cells (DC), and natural killer (NK) cells to murine cytomegalovirus infection and found distinct functions among these cell subsets. Upon recognition of infected fibroblasts, IKDC, as well as NK, produced high level of IFN-γ, but unlike NK, IKDC simultaneously produced IL-12p40 and up-regulated MHC class II (MHC-II) and costimulatory molecules. Using MHC-II molecule expression as a phenotypic marker to distinguish activated IKDC from activated NK, we further showed that highly purified MHC-II+ IKDC but not NK cross-present MHC class I–restricted antigens derived from MCMV-infected targets to CD8+ T cells in vitro and in vivo. Our findings emphasize the unique nature of IKDC as a killer antigen-presenting cell directly linking innate and adaptive immunity. [Cancer Res 2009;69(16):6607–14]
A case of Reye syndrome with rotavirus infection accompanied with high cytokines
Authors: Hiroaki Ioi, Hisashi Kawashima, Shigeo Nishimata, Yoshiaki Watanabe, Gaku Yamanaka, Yasuyo Kashiwagi, Naoto Yamada, Kazumitsu Tsuyuki, Kouji Takekuma, Akinori Hoshika, Masayoshi Kage
Journal: Journal of Infection (2005)