tbuckley/cabot-search huggingface dataset:
CLINICAL SIGNIFICANCE OF PRECEDING ANGIOGRAPHICAL FINDINGS IN PATIENTS WITH VERY LATE STENT THROMBOSIS AFTER SIROLIMUS ELUTING STENT IMPLANTATION
Authors: Takeshi Tada, Kazushige Kadota, Mitsuru Yoshino, Koshi Miyake, Haruki Eguchi, Noriyuki Ohashi, Yuki Hayakawa, Naoki Saito, Suguru Ohtsuru, Daiji Hasegawa, Yoshikazu Shigemoto, Seiji Habara, Hiroyuki Tanaka, Hiroyuki Tanaka, Shingo Hosogi, Yasushi Fuku, Naoki Saito, Harumi Kato, Hiroyuki Yamamoto, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2011)
Combination of oncolytic adenoviral therapy with chemotherapy for enhanced breast cancer cell killing.
Authors: MA Stoff-Khalili, A Nedeljkovic-Kurepa, JS Jung, BV Glover, B Wappenschmidt, K Rhiem, K Bosse, P Mallmann, DT Curiel, RK Schmutzler, MJ Mathis
Journal: Cancer Research (2009)

Abstract Abstract #2129 Oncolytic adenoviruses are emerging agents for treatment of cancer by tumor-restricted virus replication, cell lysis and virus spread. A promising oncolytic adenovirus agent, known as Ad5-24-RGD, harbors a 24-bp deletion in the E1A gene that abrogates the binding of E1A to the retinoblastoma tumor suppressor (Rb) and presents enhanced infectivity of primary cancer cells due to insertion of an Arg-Gly-Asp (RGD) motif into the fiber knob. Thus, Ad5-24-RGD has improved cancer cell infection efficiency due to expanded tropism toward alpha-v integrins. It also replicates selectively in cancer cells with Rb/p16 mutations. As with conventional therapy regimes, oncolytic virotherapy, by itself, has limited success in complete tumor eradication in both preclinical animal models and clinical studies. Combination of anticancer agents with different modes of action remains a mainstay in cancer treatment. We undertook one approach towards this end by combining oncolytic adenoviral therapy with chemotherapy. In this study, we investigated a combination treatment of breast cancer cells with Ad5-4-RGD and Docetaxel, a microtubule-stabilizing taxane that is being used in the clinic for the treatment of breast and prostate cancers and small cell carcinoma of the lung. Our results indicate a synergistic effect between Docetaxel and Ad5-24-RGD in breast cancer cell killing at a lower dose than either agent alone. These results suggest that viral replication was not inhibited by this chemotherapy treatment and that chemotherapy could reduce the amount of viral particles needed to help eradicate the tumor. Administration of lower viral loads would simultaneously improve safety and decrease immunogenicity of the vector. Likewise lower doses of chemotherapy agents would decrease toxicity and side effects. The inclusion of oncolytic adenoviruses into multimodal cancer treatment together with chemotherapy has a potential to become powerful therapeutic regimen. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 2129.
Comparison of the Effects on Renin Release of Beta Adrenergic Antagonists with Differing Properties
Authors: Michael A. Weber, Gordon S. Stokes, Judith M. Gain
Journal: Journal of Clinical Investigation (1974)

Continuous 6-h infusions of the beta adrenergic blockers d,l-propranolol or oxprenolol significantly reduced plasma renin activity (PRA) and mean blood pressure in the resting rabbit and prevented the stimulatory effects of isoproterenol on renin release and heart rate. These actions were due to blockade of beta receptors, for the inactive isomer, d-propranolol, had no effect. Despite sustained high plasma concentrations of d,l-propranolol (0.2 μg/ml) in the unstimulated animal, PRA did not fall below 36% of control values, suggesting that basal renin secretion is maintained partly by factors other than beta adrenergic mechanisms.
Brock's injuries of the Brain and Spinal Cord, and Their Coverings
Authors: Julian T. Hoff
Journal: JAMA (1974)

The medical literature on trauma of the central nervous system (CNS) has expanded substantially since the last edition of Brock's text was published 14 years ago. Although the current volume resembles its predecessor in format and general subject matter, it is commendably longer and less speculative. Forty contributors, nine of whom are emeritus professors, write from extensive clinical experience emphasizing practical approaches to CNS injuries. Their 26 chapters range from standard discussions of fractures, edema, hematomas, and the like, to thoughtful appraisals of the psychological sequelae of head injury. The analysis of simulation and malingering by Miller and Cartlidge constitutes a particularly refreshing component of a textbook on trauma. Added variety is provided by chapters on boxing, injuries of childbirth, and electrical shock. Most authors have attempted to incorporate new ideas into traditional concepts. Their works are generally well written and substantiated by lengthy lists of references. Other authors had
INFLUENCE OF DIET ON BLOOD GROUPING
Authors: JOHN HARPER
Journal: JAMA (1922)

ing repeatedly with alcohol and ether, the rats gained for a very short time or not at all, the cessation of growth occurring without evident ophthalmia.In all cases, if loss of weight on diets low in the A factor was allowed to proceed longer than a week, pulmonary affections, sore feet, diarrhea and extreme emaciation folloAved, and death could not be prevented by feeding
Usefulness of Complete Blood Counts as a Case-finding Tool in Medical Outpatients
Authors: Sigmund Rüttimann, Désirée Clémençon, Ulrich C. Dubach
Journal: Annals of Internal Medicine (1992)

To determine the usefulness of routine complete blood counts as a case-finding tool in medical outpatients.Prospective evaluation in a consecutive, unselected cohort.A university-based outpatient clinic providing primary and referral care in general internal medicine.A total of 595 patients (mean age [+/- SD], 40 +/- 15 years) making their initial clinic visit.A complete blood count was done in all patients. Components of the complete blood count that were not indicated for diagnostic or management purposes at the initial visit were classified as routine tests.The number and nature of new diagnoses leading to new patient management; the number of additional visits and diagnostic tests precipitated by positive results.Of the 2378 tests done, 1540 (65%) were routine tests. The percentages of abnormal test results for the four hematologic test components were as follows: leukocyte count, 7.6%; hemoglobin, 5.8%; mean corpuscular volume (MCV) of red blood cells, 7.9%; and platelet count, 4.5%. In only three patients (0.5%) was a new diagnosis made that led to a new management strategy (treatment of iron deficiency). Further work-up was unprofitable in 14 patients (2.4%). Two additional visits were necessary because of abnormal results on routine tests. No abnormality-associated clinical disease developed during a 15-month follow-up period in patients with unexplained abnormal results on routine hematologic tests.The routine complete blood count has limited usefulness as a case-finding tool and has a minimal effect on care in middle-aged medical outpatients.
Analysis of adherence to peak flow monitoring when recording of data is electronic
Authors: H. K Reddel
Journal: BMJ (2002)

Value of butterburAlthough the effects of butterbur have been linked to its constituents, [5][6][7] we set out to test whether its clinical effects in seasonal allergic rhinitis were comparable to those of antihistamines as judged separately and blindly by patients and their doctors.The results showed that the effects of the two treatments are similar.The trends in favour of butterbur in some measures need to be confirmed in future prospective trials.With regard to safety, butterbur was well tolerated and did not have the sedative effects associated with antihistamines.We believe butterbur should be considered for treating seasonal allergic rhinitis, particularly in cases where the sedative effects of antihistamines need to be avoided.
Expression of isoforms of nitric oxide synthase in collagenous colitis
Authors: E A B Cameron
Journal: Gut (2002)

Hypomagnesaemia due to malabsorption is not always responsive to oral magnesium oxide supplementation aloneWe read with interest the Gut File report by Dr Ross and colleagues of hypomagnesaemia due to malabsorption, eventually responding to oral magnesium oxide supplementation (Gut 2001;48:857-8).Our experience however has been different.For the past seven years we have managed a 65 year old woman with short bowel syndrome (right hemicolectomy for Duke's C colorectal carcinoma and thereafter a terminal ileal resection for abscess formation).High ileostomy output was initially difficult to manage (after excluding infection, secreting gut hormone tumours by normal hormone levels, and despite dietary and pharmacological modifications).Clinical signs of hypomagnesaemia and hypocalcaemia ensued.An initial trial with magnesium glycerophosphate (September 1992 to December 1993) was insufficient to sustain her serum magnesium levels requiring frequent "top ups" of intravenous magnesium. 1In December 1993, she was switched to magnesium oxide supplementation but despite this the frequency of intravenous magnesium "top ups" were not reduced.Compliance was not deemed to be an issue with our patient.Since then we have managed this woman while still taking magnesium oxide supplements with almost 3-6 monthly (fig 1) intravenous magnesium replacement through a peripheral line and have avoided insertion of a Hickman line and all its associated complications. 2 While we agree that a trial of magnesium oxide is prudent and until the pharmacokinetics are better understood, this preparation may not be sufficient, especially in patients with extensive resection of the small bowel, as demonstrated in our patient.
Costs and Benefits of Lead Screening-Reply
Authors: Thomas Matte
Journal: JAMA (1993)

In Reply.  —We agree with the suggestion of Pantell et al that information on the effectiveness and cost of measures to prevent morbidity should be used in formulating recommendations. However, we feel that their discussion of screening for childhood lead poisoning ignores some important facets of this complex issue.  The cursory cost-effectiveness analysis by Pantell et al has a number of limitations. First, they imply that $3396 would be too much to spend to find a lead-poisoned child, given the size of the effect of lead on IQ. In fact, on the basis of the effect of lead exposure on IQ and educational attainment, it has been estimated that preventing an increase of 0.48 μmol/L (10 μg/dL) in a child's blood lead level would produce an average increase of $11470 in the net present value of that child's expected lifetime earnings. 1 Pantell et al also exclude the costs of
Effect of Antihypertensives on Sexual Function and Quality of Life: The TAIM Study
Authors: Sylvia Wassertheil-Smoller, M. Donald Blaufox, Albert Oberman, Barry R. Davis, Charles Swencionis, Maura O'Connell Knerr, C. Morton Hawkins, Herbert G. Langford
Journal: Annals of Internal Medicine (1991)

Objective: To evaluate treatment of mild hypertension using combinations of diet and low-dose pharmacologic therapies. Design: Multicenter, randomized, placebo-controlled clinical trial. Setting: Three university-based tertiary care centers. Patients: Patients (697) 21 to 65 years of age with diastolic blood pressure between 90 and 100 mm Hg as well as weight between 110% and 160% of ideal weight. Intervention: Patients were stratified by clinical center and race and were randomly assigned to one of three diets (usual, low-sodium and high-potassium, weight loss) and one of three agents (placebo, chlorthalidone, and atenolol). Measurements: Changes in measures of sexual problems, distress, and well-being after 6 months of therapy were analyzed. Main Results: Low-dose chlorthalidone and atenolol produced few side effects, except in men. Erection-related problems worsened in 28% (95% CI, 15% to 41%) of men receiving chlorthalidone and usual diet compared with 3% (CI, 0% to 9%) of those receiving placebo and usual diet (P = 0.009) and 11% (CI, 2% to 20%) of those receiving atenolol and usual diet (P > 0.05). The weight loss diet ameliorated this effect. The low-sodium diet with placebo was associated with greater fatigue (34%; CI, 23% to 45%) than was either usual diet (18%; CI, 10% to 27%; P = 0.04) or weight reduction (15%; CI, 7% to 23%; P = 0.009). The low-sodium diet with chlorthalidone increased problems with sleep (32%; CI, 22% to 42%) compared with chlorthalidone and usual diet (16%; CI, 8% to 24%; P = 0.04). The weight loss diet benefited quality of life most, reducing total physical complaints (P < 0.001) and increasing satisfaction with health (P < 0.001). Total physical complaints decreased in 57% to 76% of patients depending on drug and diet group, and were markedly decreased by weight loss. Conclusion: In general, low-dose antihypertensive drug therapy (with chlorthalidone or atenolol) improves rather than impairs the quality of life; however, chlorthalidone with usual diet increases sexual problems in men.
The Pure-Food Bill Board of Experts.
Authors: V. C. Vaughan
Journal: JAMA (1906)

Ann Arbor, Mich., March 18, 1906. <h3>To the Editor:</h3> —Your editorial stricture on the provision in the amendment to Section 9 of the Hepburn bill providing for the appointment of a board of experts to pass on the wholesomeness or unwholesomeness of preservatives would be just if it were true, but you were laboring under a misapprehension when you made your editorial statement. You say that the decision of the board is final and that there is no appeal to the courts or to the Secretary of Agriculture. This is all wrong. The board of experts is selected by the Secretary of Agriculture, and he is instructed by the law to appoint disinterested men; the Secretary fixes the compensation allowed members of the board and he may accept or reject their findings. The Secretary of Agriculture, and he alone, is given the authority to render decisions, and even his decisions
The Prediction of Diabetic Neuropathic Plantar Foot Ulceration by Liquid-Crystal Contact Thermography
Authors: Susan J Benbow, Ah W Chan, David R Bowsher, Gareth Williams, Ian A Macfarlane
Journal: Diabetes Care (1994)

OBJECTIVE To assess whether the development of plantar foot ulceration could be predicted from the mean plantar foot temperature (MFT), as assessed by liquid-crystal contact thermography (LCT), in patients with peripheral neuropathy. RESEARCH DESIGN AND METHODS Fifty patients with painful diabetic sensorimotor neuropathy were studied prospectively. Initially, 30 patients had no significant peripheral vascular disease (PVD) (ankle:brachial systolic blood pressure ratio &amp;gt;1.0). LCT was used to assess the MFT from eight standard plantar sites. RESULTS Initial MFT was higher in the patients without PVD (28.2 ± 2.9°C, mean ± SD) than in patients with PVD (25.6 ± 1.9°C, P &amp;lt; 0.001) and in nondiabetic control subjects (25.7 ± 2.1°C, P &amp;lt; 0.001). At review, on average 3.6 (range 3.0–4.1) years later, 11 patients had died (6 of whom had PVD), and one was lost to follow-up. Six patients (seven feet) from the group without PVD had developed neuropathic plantar foot ulcers. The initial MFT was significantly higher in these seven feet (30.5 ± 2.6°C) than in the 38 feet of the 19 survivors in this group (27.8 ± 2.3°C, P &amp;lt; 0.01). Only one patient with PVD developed a plantar ulcer, although four required foot surgery for ischemie feet. CONCLUSIONS LCT is a simple, inexpensive, and noninvasive method of identifying the neuropathic foot at increased risk of ulceration. Patients with high plantar foot temperatures are at increased risk of neuropathic foot ulceration. A normal or low MFT in the neuropathic foot is a marker of PVD, which confers an increased risk of ischemie foot disease.
Images in cardiovascular medicine. An unusual case of right-sided heart failure.
Authors: C M Gaos, P J Hogan, S Wilansky
Journal: Circulation (1993)

A 57-year-old man with a history of coronary artery disease and chronic obstructive pulmonary disease was admitted to another hospital with progressive dyspnea, ascites, edema, and mild jaundice.He was transferred to St. Luke's Episcopal Hospital for further evaluation.Biplane transesophageal echocardiography (TEE) revealed an extensive tumor mass in the right atrium and left atrium (Fig 1,A) with obstruction of the superior vena cava.TEE-guided biopsy of the superior vena cava mass revealed histology of large-cell lymphoma (B-cell type).At 6-month follow-up, after appropriate chemotherapy, repeat TEE showed almost total resolution of the tumor bulk, with only a small residual mass seen in the right atrium (Fig 1 ,B).
Inability of Bone and Gallium Imaging to Differentiate Acute Gouty Arthritis from Septic Arthritis
Authors: IZZIE BOXEN
Journal: Clinical Nuclear Medicine (1986)

The results of Tc-99m imidodiphosphate (Tc-99m IDP) bone imaging and Ga-67 imaging are shown for a proven case of acute gouty arthritis. The results are indistinguishable from those for septic arthritis, and therefore should not be used to differentiate these two conditions.
Efficacy Of Omalizumab In Patients With Chronic Idiopathic/Spontaneous Urticaria With Different Background Therapy: Post Hoc Analysis Of Asteria I, Asteria II, and Glacial Studies
Authors: Jonathan A. Bernstein, Sarbjit S. Saini, Marcus Maurer, Hsin-Ju Hsieh, Hubert Chen, Janice Canvin, Thomas B. Casale, Allen P. Kaplan, Karin Rosen
Journal: Journal of Allergy and Clinical Immunology (2014)
DOCHEZ SCARLET FEVER ANTITOXIN IN THIRTY-ONE CASES
Authors: R. H. GRAHAM
Journal: JAMA (1925)

I have observed thirty-one cases treated with unconcentrated scarlet fever serum by the Dochez method. In the thirty-one patients treated, twenty-one developed serum disease. These reactions ranged in severity from slight urticarial eruptions to a generalized edema, and the temperatures as high as 105 F. Six of the cases showed anaphylaxis in the first hour. Eighteen cases either occurred or recurred from the second to the seventh day. Nine patients had an elevation of temperature from 100 to 105 F.  The following are typical of two cf the more severe cases of serum disease:  Case 1.  —A girl, aged 5 years, was exposed to scarlet fever; she was given 3 c.c. of unconcentrated scarlet fever serum. Three days later, she developed symptoms of marked generalized edema and urticaria. Accompanying these were nausea, aching pains in the extremities and a temperature ranging from 100 to 104.2 F. These symptoms subsided gradually
Acetate absorption and metabolism in the rabbit hindgut.
Authors: J F Marty, M Y Vernay, G M Abravanel
Journal: Gut (1985)

Acetate disappearance from the loops of the hindgut in the rabbit was evaluated by measuring variations in the concentration of acetate in caecocolonic loops and differences in the arterial and venous plasma. In vivo metabolism in gut and liver tissues was studied after introduction of (1-14C) acetate into caecocolonic loops. The rate of disappearance from the loops was quantitatively significant and showed little variation irrespective of the location in the hindgut. Hindgut tissue metabolised acetate and the intensity of the metabolism varied with the segment studied. The distal position of the gut showed by far the highest acetate uptake. Radioactivity was found in a certain number of free amino acids, organic acids, and sugars. Acetate was mainly converted into aspartate and glutamate. These can be considered as 'stock forms' which can be diverted either towards oxidative metabolism or towards protein synthesis.
Cholelithiasis in Identical Twins
Authors: John H. Kennard
Journal: New England Journal of Medicine (1955)

A SURVEY of the literature concerning cholelithiasis reveals no agreement on the probable etiology of this common disease. Several authors have postulated a congenital familial factor that predisposes to this condition, and a familial occurrence has been reported on several occasions.1 2 3 4 I have been able to find only one reference to cholelithiasis occurring in identical twins. Tesler,4 in 1946, reported apparent cholelithiasis in female, identical twins aged nineteen, 1 of which was proved by operation; the other had a typical history, and x-ray study showed "a poorly functioning gallbladder with radiolucent shadows suggestive of calculi."As further evidence of a . . .
Perspectives of commissioners and cancer specialists in prioritising new cancer drugs: impact of the evidence threshold
Authors: R. Foy, J. So, E. Rous, J H. Scarffe
Journal: BMJ (1999)

The provision of high quality cancer services is a major priority for the NHS.1 However, greater budgetary pressures are being placed on specialist hospitals and health authorities by several factors: Christie Hospital NHS Trust in Manchester provides specialist cancer care to a population of 4.5million people from North Wales to Cumbria. The trust's drug budget of £4 million accounted for 18% of the total income from patient services in 1996-7,creating an obvious focus for annual negotiations with commissioning health authorities. Historical underfunding of the trust's drug budget, relative to that of other oncology centres, further supported the trust's case for increased resources. Clinicians highlighted the paradox whereby only 1% of the annual NHS drug budget (£58 million) was allocated to cytotoxic drugs for treating a disease that would affect at least one in three of the population, while £200 million was spent on treating constipation.2–4 The trust was concerned that individual health authorities within its catchment area would negotiate different contracts, resulting in inequitable access to new developments, as has previously occurred with cancer treatments.5 A Greater Manchester consortium of six health authorities was established, partly as a response to this and partly to develop more efficient commissioning. The consortium, responsible for purchasing around two thirds of services from the hospital, also advised neighbouring health authorities in the catchment area. It soon became clear that the trust's proposed developments could not be met in full from available resources and the consortium agreed to set priorities in funding drug developments. This paper describes our joint experiences in prioritising drug proposals for 1997-8. ### Summary points
Action of serum on the output of secretory glycoproteins from human bronchi in vitro.
Authors: I P Williams, B Rich, P S Richardson
Journal: Thorax (1983)

The effect on mucin output of placing dilute serum from healthy donors in contact with the luminal surface of human airway has been studied. Bronchi were dissected from lungs removed at operation. Mucins, radiolabelled biosynthetically, were collected from the luminal aspect of the bronchi, which were mounted in Ussing chambers. Serum added to the luminal aspect of the tissue, at dilutions ranging from 1:100 to 1:10 of Krebs-Henseleit solution, consistently increased the output of radiolabelled mucins. The concentrations of serum tested in these experiments lie within the range commonly found in sputum coughed from the lungs of those with inflamed airways. Serum diluted to 1:2500, which is roughly the concentration found in the normal human airway, had little or no effect on bronchial secretion. Increased leakage of serum into the inflamed airways is suggested as one of the stimuli that increase bronchial secretion.