tbuckley/cabot-search huggingface dataset:
Abstract 5492: The effects of whole body hyperthermia on tumor growth by a novel far infrared emitter
Authors: Hirotsugu Uemura, Hiroshi Ushida, Chiori Asahi, Yuka Miyazaki, Kazuhiro Yoshikawa, Marco A. De Velasco
Journal: Cancer Research (2010)

Abstract Whole body hyperthermia (WBH) has been used alone or as an adjunct to radio- and/or chemotherapy for the treatment of various malignant diseases. The therapeutic effect of WBH in these conditions has been hypothesized to involve direct or indirect activation of the immune system and heat shock proteins (HSPs). In this study, we investigate the effects of hyperthermia in vitro and in vivo using BioRubber (BR, Yamamoto Bio-Technology Inc., Anaheim, CA), a revolutionary far infrared emitter on tumor growth. BR is a pliable state-of-the-art biomaterial that emits FIR in the 4-25μm spectral ranges. For the in vitro experiments, cell growth assays and cell cycle analysis was performed in a total of twelve different cancer cell lines (HeLa, bladder, prostate and renal) sandwiched between BR. BR had no inhibitory effects on any of the tumor cells grown in vitro. To determine the effects of BR therapy on tumor and normal tissue in vivo, KU7/GFP-bearing nude mice were housed in cages lined with BR for 28 days. Tumor size and core body temperature were recorded weekly. The core body temperatures of mice exposed to BR increased significantly by 1oC (P&amp;lt;0.05) after 2 weeks of exposure to BR. Although not significant, tumors of mice exposed to BR showed a clear tendency in tumor size reduction. Tumors were collected and anlyzed for histopathology, TUNEL and PCNA immunohistochemical analysis. Proliferation and apoptotic rates in tumors from mice exposed to BR were similar to control mice. Further histopathological analysis showed that BR-exposed tumors had remarkable granulocyte infiltration accompanied by increased necrosis. This suggest that BR exposure was indeed able to induce and sustain mild hyperthermia in vivo with reduced tumor growth. However, no direct inhibitory on the tumor cells resulted form BR-induced hyperthermia but rather appeared to have been an indirect effect of immuno-stimulation achieved from sustained WBH. To further investigate the immunological component of hyperthermia-induced immune response, a syngeneic tumor model was carried out using mouse RENCA cells in immunocompetent and immunodeficient mice. Similar tumor growth inhibitory effects were seen in both immunocompetent and immunodeficient mice thus suggesting an innate immune response as a result of sustained WBH. Together, these data suggest that BR may be a promising biomaterial in for use hyperthermia therapy: however, more research has to be conducted to elucidate the specific mechanisms involved in immuno-stimulation and whether the effects from BR-induced hyperthermia can be maximized with combination therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5492.
Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats.
Authors: R B Nussenblatt, M M Rodrigues, W B Wacker, S J Cevario, M C Salinas-Carmona, I Gery
Journal: Journal of Clinical Investigation (1981)

Cyclosporin A (CS-A), a selective inhibitor of T lymphocytes, is reported here to prevent S antigen (S-Ag) induced uveitis in Lewis rats. The S-Ag, found in all mammalian retinas, is uveitogenic under experimental conditions and patients with certain uveitic entities demonstrate cell mediated responses to this antigen. Daily treatment with CS-A (10 mg/kg) begun on the same day as S-Ag immunization totally inhibited the development of the uveitis in this experimental autoimmune model. Moreover a greater CS-A dose (40 mg/kg) efficiently prevented the disease process when therapy was started 7 d after S-Ag immunization. Anti-S-Ag antibody titers were observed to be similar in rats either protected or not protected with CS-A. Our data support strongly the need for T cell participation in this disease model. Since ocular inflammatory disease is an important cause of visual impairment, the data further suggest that CS-A may be useful in the treatment of patients with intractable uveitis.
A Crisis in Australian Medicine
Authors: David Green, Peter A. Castaldi
Journal: New England Journal of Medicine (1985)

IN June 1984, physicians in New South Wales (NSW), Australia, voted overwhelmingly to resign from public hospitals, and by July 2, 1559 resignations had been received by hospital administrators. These resignations were in defiance of government legislation banning doctors who resigned from rejoining the public-hospital system for seven years. The factors precipitating this confrontation between the medical profession and the government had their origin in the enabling legislation for Medicare, the government-financed system of public health care introduced in Australia on February 1, 1984.BackgroundThe Australian health care system is organized along both public and private lines. Although most . . .
WHAT IS A NORMAL PELVIS?
Authors: HERBERT THOMS
Journal: JAMA (1934)

It may be surprising at first glance that the question of what constitutes a normal female pelvis should be presented as a subject for consideration. However, in the light of recent studies, I am of the opinion that this query does offer a basis for serious discussion.  In modern textbooks on obstetrics the normal female pelvis is differentiated from the normal male pelvis by characteristics of size and shape, which are generally recognized and which do not require delineation. One of the chief differences noted is the shape and size of the superior strait or inlet. In the normal male pelvis this plane is described as more or less round, with practically equal anteroposterior and transverse diameters. On the other hand, in the normal female pelvis the plane of the superior strait is described as more oval, the transverse diameter averaging 13 cm. and the anteroposterior 11 cm.  Four facts
ANALYSIS OF PROGNOSTIC VALUE OF PERFORIN IN ENDOMYOCARDIAL BIOPSIES OF PATIENTS WITH DILATED INFLAMMATORY CARDIOMYOPATHY
Authors: Felicitas Escher, Uwe Kuehl, Dirk Lassner, Wolfgang Poller, Carsten Tschoepe, Heinz-Peter Schultheiss
Journal: Journal of the American College of Cardiology (2013)
Abstract 3509: Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents
Authors: Rui Zhang, Xing Wu, Lynn Guziec, Frank Guziec, Jack C. Yalowich, Gaik-Lean Chee, Brian B. Hasinoff
Journal: Cancer Research (2010)

Abstract Anticancer drugs that bind to DNA and inhibit DNA-processing enzymes represent an important class of anticancer drugs. Combilexin molecules, which combine DNA minor groove binder and intercalator functionalities, have the potential for increased DNA binding affinity and increased cytotoxicity due to their dual mode of DNA binding. In this study DNA minor groove binder netropsin analogs containing either a mono-N-methylpyrrole carboxamide or two units of N-methylpyrrole carboxamide linked to DNA intercalating anthrapyrazoles were synthesized. Two of the hybrid molecules which possessed bis-methylpyrrole moities and amine head groups displayed submicromolar cytotoxicity towards K562 human leukemia cells. The synthesized hybrids were also evaluated for DNA binding by measuring the increase in DNA melting temperature, for DNA topoisomerase IIα-mediated double strand cleavage of DNA, for inhibition of DNA topoisomerase IIα decatenation activity, and for inhibition DNA topoisomerase I relaxation of DNA. Several of the compounds stabilized the DNA-topoisomerase IIα covalent complex, indicating that they acted as topoisomerase IIα poisons. The results indicate that the hybrid agents have higher affinity for DNA than the parent compounds. In conclusion, a novel group of compounds combining DNA intercalating anthrapyrazoles and minor groove binding netropsin analogs have been designed, synthesized and biologically evaluated as possible novel anticancer agents. Support: CIHR, a Canada Research Chair in Drug Development, National Institutes of Health grant CA090787 to J.C.Y., the Dishman Foundation at Southwestern University and the Robert A. Welsh Foundation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3509.
Notes on the use of historical controls.
Authors: I Yoshimura, K Matsumoto
Journal: Environmental Health Perspectives (1994)

The principles and methods of incorporating historical controls in four cases (C1, stable control; C2, rare occurrence of responses; C3, small group size; C4, historical control as a reference) are discussed. Two points are emphasized: one is that the historical control should be regarded as a given condition and the other is that the historical control should be used conservatively. Incorporating historical controls is recommended only when it is advantageous under the conditional evaluation of the performance and even in the conservative use of controls. For case C1, adjusting the critical value for the Cochran-Armitage trend test is proposed. For case C2, a modified conditional trend test proposed by Yanagawa et al. is appreciated as a proper procedure. For case C3, a conservative use of interblock information is discussed. The incorporation of the historical control is not recommended for case C4.
ROENTGEN RAY INTOXICATION
Authors: S. L. Warren, G. H. Whipple
Journal: The Journal of Experimental Medicine (1923)

The x-ray has a specific effect upon the epithelium lining the crypts and covering the villi of the small intestine. A suitable dose of x-ray will destroy this epithelium in large measure, leaving empty crypts and naked villi exposed to swarms of bacteria in the intestine. Subsequently one does not observe an overwhelming invasion of the tissues, lymph, and blood by intestinal bacteria. It seems obvious therefore that the intestinal epithelium is not the all important barrier which protects the tissues from invasion by intestinal bacteria.
Fatal Intestinal Obstruction Following Injection Treatment of an Inguinal Hernia
Authors: Knowles B. Lawrence
Journal: New England Journal of Medicine (1948)

THE injection treatment of hernia is now so little practiced in regular surgical circles in New England that its results, favorable or unfavorable, are rarely observed. This report deals with a patient in whom a complete obstruction of the small intestine was attributable to the inflammatory reaction and adhesions produced by the injection treatment of an inguinal hernia.Case ReportH. J., a 57-year-old man, was admitted to the Burbank Hospital, Fitchburg, Massachusetts, on June 5, 1946, complaining of abdominal distention and constipation of 2 days' duration. This patient had had a reducible right inguinal hernia for several years and . . .
Book Review The Alternative Medicine Handbook: The complete reference guide to alternative and complementary therapies By Barrie R. Cassileth. 340 pp. New York, W.W. Norton, 1998. $25. 0-393-04566-8 Alternative Medicine and Ethics (Biomedical Ethics Reviews.) Edited by James M. Humber and Robert F. Almeder. 220 pp. Totowa, N.J., Humana Press, 1998. $49.50. 0-89603-440-2
Authors: Avrum Bluming
Journal: New England Journal of Medicine (1998)
Community models of mental care warrant more governmental support
Authors: Malcolm W Battersby
Journal: BMJ (2004)

Although developed countries are relatively well resourced there is an unmet demand for mental health services, particularly for anxiety disorders and depression. A similar and escalating demand exists for services for other forms of chronic illness too, such as diabetes secondary to obesity. In both, the potential of community care is increasingly recognised.

The core elements that emerge from the models McKenzie et al describe are community involvement in the planning and delivery of services, harnessing social support, and providers with a diversity of skill levels in stepped services.1 Replicating these models in wealthy countries would require overcoming considerable barriers in the form of system inertia, multiple funders, funding that creates disincentives to provide alternative services, …
Regional Medical Programs and Office of Management and Budget — Parallel Philosophies
Authors: Morton C. Creditor, Dexter Nelson
Journal: New England Journal of Medicine (1973)

Abstract The Regional Medical Program is being phased out although the Program process is consistent with the apparent strategies of the administration as implied in the explanation for the fiscal 1974 health budget. The Regional Medical Program is a decentralized policy and decision-making process responsive to local need as determined by a broadly based expert constituency. In spite of an original emphasis on categorical disease, it has demonstrated flexible capability for addressing major health issues on a comprehensive basis. We recommend that the Program process be used on behalf of mechanisms such as revenue sharing that will be established and administered at state and local level to replace the federal subsidy programs from which support is being withdrawn. (N Engl J Med 289:239–242, 1973)
CASE OF HYDROCEPHALUS IN A CHILD, SIX MONTHS OLD, IN WHICH THE HEAD WAS TAPPED EIGHT TIMES
Authors: J. D. Brown
Journal: BMJ (1854)

Sw bom gradually ehausted, ad did not Iong suve the fotion of the second abscess.Unfortunately a poat hfr exmintion could not be obtained.In this case thee was t dullness on percusson over a considerable portion of the right side, and only slight respiratory murmur could be heard anteriorly at the upper part of the chest, in the subclavicular space, and posteriorly near the spine.Dr.An cites two cases of thoracentesis for acute (pu- rulent) pleurisy by Dr. Trousseau, but both terminated fatally at last, which was not remarkable, as they were complicated with other serious affections.Dr. Trousseau
A PILOT STUDY OF LEFT VENTRICULAR EJECTION FRACTION RESERVE DURING REGADENOSON RUBIDIUM-82 MYOCARDIAL PERFUSION IMAGING AND THE MAGNITUDE OF ISCHEMIA AND CAD
Authors: Edward Hsiao, Bilal Ali, Ron Blankstein, Raymond Kwong, Marcelo Di Carli, Sharmila Dorbala
Journal: Journal of the American College of Cardiology (2010)
Medulloblastoma Cerebelli
Authors: Franc D. Ingraham, Orville T. Bailey, Wiley F. Barker
Journal: New England Journal of Medicine (1948)

SINCE the first description of medulloblastoma cerebelli was published by Bailey and Cushing1 in 1925, this rapidly growing tumor of the cerebellum has been recognized as occurring most often in children and leading to the abrupt onset of increased intracranial pressure and cerebellar dysfunction. Evidence has accumulated, however, that this typical syndrome is not always found in patients with medulloblastoma cerebelli and also that certain other tumors of the cerebellum give clinical symptoms indistinguishable from those of medulloblastoma. It is well known that medulloblastomas are much more successfully treated by irradiation than by radical extirpation. The place of surgery in . . .
Bacterial induction of autoantibodies to β2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome
Authors: Miri Blank, Ilan Krause, Mati Fridkin, Nathan Keller, Juri Kopolovic, Iris Goldberg, Ana Tobar, Yehuda Shoenfeld
Journal: Journal of Clinical Investigation (2002)

The antiphospholipid syndrome (APS) is characterized by the presence of pathogenic autoantibodies against beta2-glycoprotein-I (beta2GPI). The factors causing production of anti-beta2GPI remain unidentified, but an association with infectious agents has been reported. Recently, we identified a hexapeptide (TLRVYK) that is recognized specifically by a pathogenic anti-beta2GPI mAb. In the present study we evaluated the APS-related pathogenic potential of microbial pathogens carrying sequences related to this hexapeptide. Mice immunized with a panel of microbial preparations were studied for the development of anti-beta2GPI autoantibodies. IgG specific to the TLRVYK peptide were affinity purified from the immunized mice and passively infused intravenously into naive mice at day 0 of pregnancy. APS parameters were evaluated in the infused mice on day 15 of pregnancy. Following immunization, high titers of antipeptide [TLRVYK] anti-beta2GPI Ab's were observed in mice immunized with Haemophilus influenzae, Neisseria gonorrhoeae, or tetanus toxoid. The specificity of binding to the corresponding target molecules was confirmed by competition and immunoblot assays. Naive mice infused with the affinity-purified antipeptide Ab's had significant thrombocytopenia, prolonged activated partial thromboplastin time and elevated percentage of fetal loss, similar to a control group of mice immunized with a pathogenic anti-beta2GPI mAb. Our study establishes a mechanism of molecular mimicry in experimental APS, demonstrating that bacterial peptides homologous with beta2GPI induce pathogenic anti-beta2GPI Ab's along with APS manifestations.
Reviews and Notes: Oncology: Cancer &amp;amp; Natural Medicine: A Textbook of Basic Science and Clinical Research
Authors: Sigmund B. Kahn
Journal: Annals of Internal Medicine (1996)

Literature of Medicine1 September 1996Reviews and Notes: Oncology: Cancer & Natural Medicine: A Textbook of Basic Science and Clinical ResearchSigmund B. KahnSigmund B. KahnAllegheny University Hospitals—Center City, Philadelphia, PA 19102Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00042 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail J Boik. 315 pages. Princeton, MN: Oregon Med Pr; 1995. $45.00. ISBN 0-9648280-0-6. Order phone 612-389-0768.I was reluctant to review this book; its title suggested that it might be another treatise on the benefits of unproven methods in the treatment of cancer. But the scientific method is supposed to make no judgments about a hypothesis, save that the issue be testable, and, given the book's subtitle, I decided to give it a try. I'm glad I did, because I was rewarded with much information about many of the remedies that some patients find in the health food store. However, ... Author, Article, and Disclosure InformationAffiliations: Allegheny University Hospitals—Center City, Philadelphia, PA 19102 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1996Volume 125, Issue 5Page: 429-430KeywordsAcupunctureCancer geneticsCancer treatmentComplementary and alternative medicineFoodHIVHealth information technologyPathogenesisResearch designTraditional Chinese medicine ePublished: 15 August 2000 Issue Published: 1 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Binding Site for TRAF2 and TRAF3 but Not for TRAF6 Is Essential for CD40-Mediated Immunoglobulin Class Switching
Authors: Haifa H Jabara, Dhafer Laouini, Erdyni Tsitsikov, Emiko Mizoguchi, Atul K Bhan, Emanuela Castigli, Fatma Dedeoglu, Vadim Pivniouk, Scott R Brodeur, Raif S Geha
Journal: Immunity (2002)
Unwalkable Neighborhoods, Poverty, and the Risk of Diabetes Among Recent Immigrants to Canada Compared With Long-Term Residents
Authors: Gillian L. Booth, Maria I. Creatore, Rahim Moineddin, Peter Gozdyra, Jonathan T. Weyman, Flora I. Matheson, Richard H. Glazier
Journal: Diabetes Care (2012)

This study was designed to examine whether residents living in neighborhoods that are less conducive to walking or other physical activities are more likely to develop diabetes and, if so, whether recent immigrants are particularly susceptible to such effects.We conducted a population-based, retrospective cohort study to assess the impact of neighborhood walkability on diabetes incidence among recent immigrants (n = 214,882) relative to long-term residents (n = 1,024,380). Adults aged 30-64 years who were free of diabetes and living in Toronto, Canada, on 31 March 2005 were identified from administrative health databases and followed until 31 March 2010 for the development of diabetes, using a validated algorithm. Neighborhood characteristics, including walkability and income, were derived from the Canadian Census and other sources.Neighborhood walkability was a strong predictor of diabetes incidence independent of age and area income, particularly among recent immigrants (lowest [quintile 1 {Q1}] vs. highest [quintile 5 {Q5}] walkability quintile: relative risk [RR] 1.58 [95% CI 1.42-1.75] for men; 1.67 [1.48-1.88] for women) compared with long-term residents (Q1 to Q5) 1.32 [1.26-1.38] for men; 1.24 [1.18-1.31] for women). Coexisting poverty accentuated these effects; diabetes incidence varied threefold between recent immigrants living in low-income/low walkability areas (16.2 per 1,000) and those living in high-income/high walkability areas (5.1 per 1,000).Neighborhood walkability was inversely associated with the development of diabetes in our setting, particularly among recent immigrants living in low-income areas.
Abstract 3276: Identifying cross-phenotype inflammatory effects in cancer
Authors: Keston Aquino-Michaels, Vasya Trubetskoy, Hae Kyung Im, Nancy Cox
Journal: Cancer Research (2014)

Abstract Through genome-wide association studies we now better understand many of the genetic factors contributing to cancer. However, the overlap between cancer associated loci and inflammation associated loci remains poorly understood. Inflammation has long been considered the underlying basis to several complex traits and plays well-established roles in elevating risk to various cancer types. In fact, genome-wide association studies have identified loci associated with inflammatory biomarkers and risk of cancer. Therefore we sought to test cross-phenotype genetic effects between cancer and inflammation biomarkers. While genome-wide significant loci on their own typically account for very little of the measured narrow-sense heritability, polygenic approaches show greater promise to account for the missing heritability of complex traits. Therefore we built polygenic signatures from inflammatory biomarker genome-wide association studies. Preliminary analysis of a case control pancreatic cancer dataset (304 cases/1425 controls) where we applied seven inflammatory signatures indicates that polygenic scores built from IL-10 and C-reactive protein (CRP) are significant predictors of case control status. Importantly the directions of effect for IL-10 and CRP are consistent with the canonical roles of these proteins. We extended this approach to a breast cancer dataset (1082 cases/1086 controls) where we found that polygenic scores built from CRP are significant predictors of case control status. In both the pancreatic and breast cancer datasets CRP polygenic scores decrease risk of case status. This approach will not only inform us of the cancers with overlapping inflammatory effects, but also allow us to identify the components of the immune system that mediate cancer risk. Ultimately this understanding may lead to the use of anti-inflammatory medication for individuals at risk for a particular cancer. Therefore this research addresses cancer prevention by studying the inflammatory genetic component to risk. Citation Format: Keston Aquino-Michaels, Vasya Trubetskoy, Hae Kyung Im, Nancy Cox. Identifying cross-phenotype inflammatory effects in cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3276. doi:10.1158/1538-7445.AM2014-3276