tbuckley/cabot-search huggingface dataset:
Coombs'-Positive Hemolytic Disease in Malaria
Authors: MARVIN M. ADNER
Journal: Annals of Internal Medicine (1968)

In a study of 131 soldiers evacuated from Vietnam with drug-resistant Plasmodium falciparum malaria, 4 patients were found with a positive direct antiglobulin test of the immunoglobulin (Ig) G type. In three patients the positive Coombs' tests seemed temporally related to the administration of quinine for relapsed malaria and were associated with hemolysis. Two of these patients had a quinine-related dermatitis, one developed blackwater fever within hours after the initiation of quinine therapy, and another had a panagglutinin in quinine-free red cell eluates. The fourth patient had compensated hemolysis and a positive direct Coombs' test which seemed unrelated to quinine therapy. The indirect Coombs' test was negative in all subjects, and no antiquinine antibodies were found in sera or red cell eluates from these patients. Coombs'-positive hemolytic disease is an unusual complication of malarial infections. Clinical observations in man suggest that quinine has a causal role in the hemolytic reaction. The mechanism by which this drug-induced hemolysis occurs is not known.
Rheumatology: A Primary Care Approach
Authors: S. Hull
Journal: Annals of the Rheumatic Diseases (1983)

The first quarter of the 230 or so pages is devoted to 'A M. Rothschild.Pp. 416.£41-75.Yorke Medical: new look at rheumatoid arthritis'.This is a stimulating and New York. 1983.informative, if somewhat indigestible, dissertation by T. Bitter of Lausanne, in support of more precise diagnostic This volume aims to help the primary care physician provide criteria and more aggressive drug therapy in rheumatoid continuing care for his rheumatological patients.The title arthritis.The use of drug combinations, their mode of could be misleading to the English reader, in that 'primary action, and the semantic and conceptual questions raised by care' in the United States is given by a wide variety of rheumatoid-factor-negative polyarthritis, are all discussed.
Mixing Politics and Zen
Authors: James L. Reinertsen
Journal: Annals of Internal Medicine (2004)

Letters6 April 2004Mixing Politics and ZenJames L. Reinertsen, MDJames L. Reinertsen, MDFrom Institute for Healthcare Improvement, Boston, MA 02215.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-7-200404060-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The purpose of my short essay was to place the issue of “using the science we know, reliably,” squarely on our professional agenda as physicians by connecting it directly to a strongly held professional value: autonomy. That using the science we know would improve patient outcomes and would also increase the time physicians desperately need to perform the artful custom-crafting of care that each patient requires resonates deeply with another core professional value, that of patient-centered altruism. These are the keywords for an internal professional debate, and perhaps for a much-needed revitalization of medicine. They were not intended ... Author, Article, and Disclosure InformationAffiliations: From Institute for Healthcare Improvement, Boston, MA 02215. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoZen and the Art of Physician Autonomy Maintenance James L. Reinertsen Mixing Politics and Zen W. Harry Horner Metrics 6 April 2004Volume 140, Issue 7Page: 585KeywordsDrug safetyEvidence based medicinePatientsSafety ePublished: 6 April 2004 Issue Published: 6 April 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Occupational Exposure Risks in Individuals with PI*Z α<sub>1</sub>-Antitrypsin Deficiency
Authors: ANNYCE S. MAYER, JAMES K. STOLLER, BECKI BUCHER BARTELSON, A. JAMES RUTTENBER, ROBERT A. SANDHAUS, LEE S. NEWMAN
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

We obtained questionnaire and spirometry data from 128 alpha(1)-antitrypsin (alpha(1)AT)-deficient individuals with phenotype PI*Z to examine the relationship between chronic respiratory symptoms, airflow limitation, treatment requirements, and semiquantitative estimates of occupational exposure to dust, fumes, smoke, and gas. After adjusting for age, smoking, and prior lower respiratory tract infections, increased prevalence of chronic cough (OR = 4.69, 95% CI = 1.57-13.74, p = 0.006) and having left a job due to breathlessness (OR = 2.72, 95% CI = 1.07-6.92, p = 0.036) were seen in individuals reporting high mineral dust exposure compared with those with no exposure. Subjects reporting high mineral dust exposure also had significantly lower FEV(1) (31% predicted for high exposure versus 36% for low and 40% for unexposed, p = 0.032). The excess risk of chronic cough seen with occupational fumes or smoke exposure disappeared after adjusting for mineral dust exposure, but the association with lower FEV(1)/FVC ratio persisted (p = 0.022). Personal tobacco use was a significant risk factor for most outcome measures, but no interaction with occupational exposure was seen. These results suggest that occupational inhalational exposures are independently associated with respiratory symptoms and airflow limitation in severely alpha(1)AT-deficient individuals.
Campylobacter pylori, duodenal ulcer disease, and gastrin.
Authors: S. Levi, C. T. Dollery, S. R. Bloom, J. Calam, T. M. Cox, H. J. Hodgson, M. S. Losowsky, M. B. Pepys, N. A. Wright, O. M. Wrong
Journal: BMJ (1989)

Campylobacterpylori is a gram negative spiral bacterium that produces a powerful urease that splits urea with the production ofammonia.By neutralising intragastric pH with ammonia C pylori is able to colonise the stomach and survive conditions unsuitable for other bacteria.We present a patient who illustrates the relation between C pylori and plasma gastrin concentration and whose duodenal ulcer disease was healed only after treatment was aimed at eradication of C pylon.
Ventricular tachycardias arising from the aortic sinus of valsalva: an under-recognized variant of left outflow tract ventricular tachycardia
Authors: Logan Kanagaratnam, Gery Tomassoni, Robert Schweikert, Stephen Pavia, Dianna Bash, Salwa Beheiry, Mark Niebauer, Walid Saliba, Mina Chung, Patrick Tchou, Andrea Natale
Journal: Journal of the American College of Cardiology (2001)
Endoscopic diverticulotomy by harmonic scalpel (Ultracision): an experimental model
Authors: F. Hondo, F. Maluf-Filho, J. Giordano-Nappi, R. Duarte, R. Kuga, E. Grecco, M. Srougi, P. Sakai
Journal: Endoscopy (2009)

Treatment of Zenker's diverticulum by flexible endoscopy is considered to be feasible and safe [1]. Bleeding and perforation remain the main complications of endoscopic incision of Zenker's diverticulum [2]. The harmonic scalpel (Ultracision) ([Fig. 1]) has been employed in laparoscopic surgery [3] and provides adequate and accurate hemostasis. The concept of a harmonic scalpel involves coaptive coagulation in which vessels are tamponaded and sealed by a protein coagulum or desiccated tissue, or both. Coagulation with the ultrasonically activated scalpel blade is always coaptive, and vessels are sealed by a denatured protein coagulum [3].
Switching prescription drugs to over the counter: Chicken and egg scenario is possible
Authors: Magnus Hird
Journal: BMJ (2005)

EDITOR—Cohen et al suggest that prescription drugs become candidates for switching to being available over the counter if they meet three criteria: use for non-chronic conditions, easy to self diagnose, low potential for misuse.1 Whether this is the policy of drug regulators is unclear.

Perhaps this view is drawn from examination of current over the counter products? …
Film: Dirty Pretty Things
Authors: A. Ellis
Journal: BMJ (2002)

Directed by Steven Frears UK release date: 13 December US release scheduled for April 2003 ——————— Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> This gritty British film centres on a hotel night porter who finds a human heart blocking the toilet in one of the guest rooms. The story builds up a complex and desperate picture of asylum seekers in the United Kingdom. Okwe (played by Chiwetel Ejiofor) is a Nigerian doctor working in London (as a taxi driver by day and a hotel porter by night). He doesn't like to sleep and grinds away in a daily quest … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Imaging Tumors of the Central Nervous System and Extracranial Head and Neck
Authors: H. R. Harnsberger, W. P. Dillon
Journal: CA A Cancer Journal for Clinicians (1987)

Both CT and MRI address the pertinent clinical issues in the management of patients with squamous cell carcinoma of the upper aerodigestive tract and neck, and are crucial to staging, treatment, and follow-up. By combining the clinical assessment of primary mucosal extent with the objective information provided by CT or MRI about deep tissue extension of the primary tumor and any nodal metastases, accurate assessment of the actual pretreatment primary tumor and nodal stages is possible. With this objective picture of tumor extent, decisions about surgery and radiotherapy can be made for primary and recurrent tumors, as well as for nodal metastases.
The control of Staphylococcus epidermidis biofilm formation and in vivo infection rates by covalently bound furanones
Authors: E.B.H. Hume, J. Baveja, B. Muir, T.L. Schubert, N. Kumar, S. Kjelleberg, H.J. Griesser, H. Thissen, R. Read, L.A. Poole-Warren, K. Schindhelm, M.D.P. Willcox
Journal: Biomaterials (2004)
ACCF/ACR/AHA/NASCI/SCMR 2010 Expert Consensus Document on Cardiovascular Magnetic Resonance
Authors: W. Gregory Hundley, David A. Bluemke, J. Paul Finn, Scott D. Flamm, Mark A. Fogel, Matthias G. Friedrich, Vincent B. Ho, Michael Jerosch-Herold, Christopher M. Kramer, Warren J. Manning, Manesh Patel, Gerald M. Pohost, Arthur E. Stillman, Richard D. White, Pamela K. Woodard
Journal: Circulation (2010)
A SIMPLE METHOD OF APPROXIMATING THE PROPER RATION FOR A DIABETIC PATIENT
Authors: J. H. KELLOGG
Journal: JAMA (1923)

The difficulty in arranging the ration, or bill of fare, in a new case of diabetes is to know where to begin. The ordinary "cut and try" method often involves a great waste of time and may work to the serious disadvantage of the patient. This method is clumsy and unscientific, and is about as reasonable as would be the action of a tailor if, instead of measuring his customer for a coat, he should make a guess as to the dimension of the garment, make and try it on, and if he found it a misfit, make another, and if he found this a misfit, proceed to make still another, so continuing until by gradual approximations a proper fit might in time be attained, and then charging up to the patient the total cost of the time and material employed in wasteful experimentation. All competent internists who have had
Compatibility of Normal Renal Function With Aging
Authors: Jack Lapides
Journal: JAMA (1967)

Serum creatinine and 15-minute phenolsulfonphthalein excretion levels were obtained on 1,000 male and female patients, ranging from 25 to 94 years of age. The renal function tests were used to estimate each patient's glomerular and tubular activity in a quantitative fashion. Correlation of kidney function with the patient's age revealed that one third of the patients 65 years or older had normal glomerular and tubular function. More than two thirds of the elderly individuals demonstrated normal glomerular function.
Detection of Hemangiomas Using Whole-body Imaging with Technetium-99m Labeled RBCs
Authors: JEREMY J. HOLLERMAN, MARC A. BERNSTEIN, JERRY W. FROELICH, GEORGE SCHKUDOR
Journal: Clinical Nuclear Medicine (1986)

Hemangiomas are easily, quickly and relatively noninvasively detected using whole-body imaging with Tc-99m labeled RBCs. A case in which this method was used to confirm known lesions and detect additional unsuspected lesions is described. This method can also be useful in the detection and evaluation of other types of vascular malformations, such as arteriovenous communications. The lesions must be of sufficient size and flow to be seen. Applications include the examination of patients known to have one vascular malformation in a search for additional lesions and the screening of relatives of patients with familial conditions that include hemangiomas.
Guidelines for Computer Modeling of Diabetes and Its Complications
Authors: Adrian Bagust, Philip McEwan
Journal: Diabetes Care (2005)

The ADA consensus panel guidelines for computer modeling (1) may create a misleading and unduly optimistic view of modeling for general readers. Repeated use of the terms “accurate” and “reliable” suggests that models are capable of generating precise predictions of long-term clinical outcomes and costs. Sadly, models do no more than encompass our current understanding (and ignorance) of a disease, its treatment , and its natural history. Despite powerful computers and sophisticated software, no model generates new data—it merely combines existing findings within a framework of …
A study of 72 patients with contact allergy to tioconazole
Authors: H. HEIKKILÄ, S. STUBB, S. REITAMO
Journal: British Journal of Dermatology (1996)

Over a 3 1/2 year period, from 1991 to 1994, we detected contact allergy to tioconazole in 72 patients by epicutaneous testing. During this period, tioconazole was included in the standard series of epicutaneous tests. Except for the first 6 months, the incidence of positive patch test reactions to tioconazole was over 1% of patients tested for contact allergy. As well as those tested with the standard series, 18 additional patients with tioconazole allergy were detected by direct testing with an imidazole patch test series. Of the various imidazole derivatives, tioconazole was the most important contact allergen. About half of patients with contact hypersensitivity to tioconazole, had additional contact allergies detected by the standard series. Men and women were equally affected. The present study suggests that tioconazole is an important contact allergen, which should be included into the patch test series in countries where it is used as a topical antifungal agent.
THE ACUTE EFFECTS OF PASSIVE SMOKING ON MEAN PLATELET VOLUME LEVELS IN HEALTHY VOLUNTEERS
Authors: Mikail Yarlýoglues, Mehmet Gungor Kaya, Ibrahim Ozdogru, Ali Dogan, Idris Ardic, Orhan Dogdu, Abdurrahman Oguzhan, Ali Ergin
Journal: Journal of the American College of Cardiology (2011)
First-in-Human Evaluation of Anti–von Willebrand Factor Therapeutic Aptamer ARC1779 in Healthy Volunteers
Authors: James C. Gilbert, Tia DeFeo-Fraulini, Renta M. Hutabarat, Christopher J. Horvath, Patricia G. Merlino, H. Nicholas Marsh, Judith M. Healy, Sleiman BouFakhreddine, Thomas V. Holohan, Robert G. Schaub
Journal: Circulation (2007)

Background— ARC1779 is a therapeutic aptamer antagonist of the A1 domain of von Willebrand Factor (vWF), the ligand for receptor glycoprotein 1b on platelets. ARC1779 is being developed as a novel antithrombotic agent for use in patients with acute coronary syndromes. Methods and Results— This was a randomized, double-blind, placebo-controlled study in 47 healthy volunteers of doses of ARC1779 from 0.05 to 1.0 mg/kg. Pharmacodynamic effects were measured by an ELISA for free vWF A1 binding sites and by a platelet function analyzer. In terms of pharmacokinetics, the concentration-time profile of ARC1779 appeared monophasic. The observed concentration and area under the curve were dose proportional. The mean apparent elimination half-life was ≈2 hours, and mean residence time was ≈3 hours. The mean apparent volumes of distribution (at steady state and during terminal phase) were approximately one half the blood volume, suggesting that ARC1779 distribution is in the central compartment. The mean clearance ranged from ≈10% to ≈21% of the glomerular filtration rate, suggesting that renal filtration may not be a major mechanism of clearance of ARC1779. Inhibition of vWF A1 binding activity was achieved with an EC 90 value of 2.0 μg/mL (151 nmol/L) and of platelet function with an EC 90 value of 2.6 μg/mL (196 nmol/L). ARC1779 was generally well tolerated, and no bleeding was observed. Adverse events tended to be minor and not dose related. Conclusions— This is the first-in-human evaluation of a novel aptamer antagonist of vWF. ARC1779 produced dose- and concentration-dependent inhibition of vWF activity and platelet function with duration of effect suitable for the intended clinical use in acute coronary syndromes.
Inability to Assess Breath Sounds During Air Medical Transport by Helicopter
Authors: Richard C. Hunt
Journal: JAMA (1991)

This study assessed the capabilities of a traditional and an amplified stethoscope used by flight nurses to assess breath sounds during air medical transport in an MBB BO-105 helicopter. We developed a normal breath sound model using a prerecorded tape of breath sounds interspersed with segments without breath sounds; the recorder had been placed in the chest wall of a resuscitation training manikin. Flight nurses completed control listening sessions in a quiet environment and experimental sessions during flight using a traditional stethoscope for half of the sessions and an amplified stethoscope for the remaining half. In the quiet environment, flight nurses accurately reported the presence or absence of breath sounds in 110 (92%) of 120 trials. During helicopter flight, none of the flight nurses heard breath sounds during any of the recorded segments with either the traditional stethoscope or the amplified stethoscope. We conclude that flight nurses are unable to hear normal breath sounds using a traditional or amplified stethoscope during flight in a medically configured MBB BO-105 helicopter. Improved stethoscopes, innovative methods of listening, and reduction of aircraft noise are potential solutions to the problems of breath sound assessment during air medical transport. (<i>JAMA</i>. 1991;265:1982-1984)
Histamine releasing factor (TCTP) is an auto-reactive IgE-binding antigen in patients allergic to Cladosporium herbarum*1
Authors: C. Holler, B. Simon-Nobbe, V. Wally, R. Crameri, K. Richter, A. Hartl, J. Thalhamer, C. Ebner
Journal: Journal of Allergy and Clinical Immunology (2004)
The International Hippocratic Foundation of Cos
Authors: Chauncey D. Leake
Journal: JAMA (1961)

<h3>To the Editor:—</h3> Word has been received of the organization of the International Hippocratic Foundation of Cos. This program was proposed in 1959 by Professor Spyridon Oeconomos of Athens and after considerable international negotiation was formulated in August, 1960, in connection with 17th International Congress of the History of Medicine, which met in Athens and Cos. The International Hippocratic Foundation of Cos is legally constituted under the patronage of Paul, King of the Hellenes, and the Greek government. The aims of the organization are to maintain and extend the rationalistic ideals and standards of Hippocratic medicine, to develop a humanized medicine with the purpose of improving human well-being, and to establish an international center for historical study in medicine at Cos. Membership in the International Hippocratic Foundation of Cos is open to anyone holding a diploma of a faculty of medicine who will make a modest contribution of a dollar
Chronic Fatigue Syndrome
Authors: Todd Janus
Journal: JAMA (1991)

<h3>To the Editor.—</h3> Gold et al<sup>1</sup>studied chronic fatigue syndrome and EBV. At enrollment of study subjects, all were negative for the antibody to human immunodeficiency virus. However, they fail to mention if any of the subjects converted to positive for the antibody while enrolled in the project (mean duration, 11.3 months, with a range of 3 to 21 months). Did any subjects seroconvert during the follow-up, and, if so, did this play a role in patient outcome?
The Diagnosis Game
Authors: Edward L. Parsons
Journal: JAMA (1972)

<h3>To the Editor.—</h3> I was appalled by the article by Drs. Schneiderman and Muller entitled "The Diagnosis Game" (<b>219</b>:333, 1972). We have become excessively gadget-oriented in recent years; one of the greatest criticisms of our profession is our apparent loss of human contact with our patients. This little game with the computer, although of considerable value I am sure, can have only one major effect upon developing medical students: a dehumanizing of clinical medicine. In strict terms of medical education, a student who places laboratory tests above a careful history and physical examination (which adds much subtle emotional and observational information not easily programmed into a computer!) is not my idea of a doctor.
Ewing's Sarcoma–Like Tumors Originate from EWS-FLI-1-Expressing Mesenchymal Progenitor Cells
Authors: Nicolo Riggi, Mario-Luca Suvà, Ivan Stamenkovic
Journal: Cancer Research (2006)

In Response: 

Our study was directed toward identifying a primary cell that is permissive for EWS-FLI-1-mediated transformation. Following the observation that EWS-FLI-1 transforms primary mouse mesenchymal progenitor cells (MPC) to form Ewing's sarcoma–like tumors ( [1][1]), we tested these
PHARMACOLOGY IN THE WAR
Authors: TORALD SOLLMANN
Journal: JAMA (1918)

It is the problem of the war for a country to meet and to defeat not only the human enemy, but the forces of nature. Severe necessity arises in many forms, in many new garbs. That, however, brings out one of the compensations of the war: Necessity is the mother of invention, of conservation, of efficiency. The happy-go-lucky ways of peace no longer suffice. Every form of human endeavor is forced to the supreme effort. Let us see what part the subjects of pharmacology and therapeutics have played and can play in the struggle. What in particular our own country has done and can do in this field. The very opening of the war emphasized the problems of infections. The brilliant successes of serum therapy have robbed infections of much of their terror; but there was still far too much that remained unsolved. There was still a large scope for
Two-Year Statin Therapy Does Not Alter the Progression of Intima-Media Thickness in Patients With Type 2 Diabetes Without Manifest Cardio-vascular Disease: Response to Beishuizen et al.
Authors: Arrigo F.G. Cicero, Antonio V. Gaddi, Giuseppe Derosa
Journal: Diabetes Care (2005)

We thank Cicero et al. (1) for their comments on our article (2). We measured intima-media thickness (IMT) at baseline and after 1 and 2 years. Thus, the assertion by Cicero et al. that we “should have concluded that 15.4 months of treatment with 0.4 mg cerivastatin…is not efficacious in reducing IMT progression in type 2 diabetic subjects” cannot, in our view, be drawn from the data as gathered. Although the level of LDL cholesterol was significantly higher during 20-mg simvastatin treatment compared with 0.4-mg cerivastatin treatment (2.56 …
Clinical and magnetic resonance imaging features of cricket bowler’s side strain
Authors: D Humphries, M Jamison
Journal: British Journal of Sports Medicine (2004)

The clinical features of 10 cases of lateral trunk muscle injury in first class cricket pace bowlers are described. Typically the injury occurs during a single delivery, is associated with considerable pain, and prevents the bowler from continuing. The clinical picture is typical of a muscular or musculotendinous injury. The most consistent clinical tests were focal tenderness on palpation and pain with resisted side flexion towards the painful side. The magnetic resonance image in 70% of cases was consistent with an injury to the internal oblique, the external oblique, or the transversalis muscles at or near their attachments to one or more of the lowest four ribs. The injury occurs on the non-bowling arm side. Recovery can be prolonged. The injury was a recurrence in six of the 10 cases. The biomechanics of the injury are not yet understood.