tbuckley/cabot-search huggingface dataset:
Language Acquisition in Relation to Cumulative Posttraumatic Stress Disorder Symptom Load over Time in a Sample of Resettled Refugees
Authors: Hans Peter Söndergaard, Töres Theorell
Journal: Psychotherapy and Psychosomatics (2004)

&lt;i&gt;Objective:&lt;/i&gt; To study the effects of symptoms of posttraumatic stress disorder (PTSD), depression and dissociation as well as cumulative symptom load on language learning during the introduction phase in resettled refugees. &lt;i&gt;Method:&lt;/i&gt; Participants were resettled refugees of Iraqi origin. They were assessed by means of a structured interview for PTSD at baseline as well as self-rating questionnaires. Language acquisition was studied by means of register data from the school system. Five levels of language proficiency were recorded. Self-reported symptom scores for PTSD, depression and dissociation (Impact of Events Scale-22, Hopkins Symptom Checklist-25, Dissociative Experiences Scale) were measured at four time points during 9 months immediately after resettlement. In 49 participants in a longitudinal study, data regarding progress in language studies were accessible. &lt;i&gt;Results:&lt;/i&gt; The results of the study indicate that the speed of language acquisition – the number of levels taken during the study, adjusted to hours of school presence – is related to the cumulative PTSD symptom load over time (Events Scale-22), but is not related neither to the symptom load of depression and dissociation, nor to the number of previous school years. &lt;i&gt;Conclusion:&lt;/i&gt; The study shows that the symptom load of PTSD during the follow-up period is significantly inversely related to the speed of language acquisition in refugees. This implies that treatment as well as preventive measures against worsening of PTSD symptoms are important in order to minimise harmful post-migration stress for the facilitation of integration.
Guidelines for Training in Gallstone Lithotripsy
Authors: David L. Earnest, James R. Adwers, William D. Carey, William J. Casarella, Seymour Katz, Peter M. Loeb, David L. Nahrwold, Seymour M. Sabesin, James C. Thompson, Jack A. Vennes
Journal: Annals of Internal Medicine (1991)

Position Paper1 June 1991Guidelines for Training in Gallstone LithotripsyDavid L. Earnest, MD, James R. Adwers, MD, William D. Carey, MD, William J. Casarella, MD, Seymour Katz, MD, Peter M. Loeb, MD, David L. Nahrwold, MD, Seymour M. Sabesin, MD, James C. Thompson, MD, Jack A. Vennes, MDDavid L. Earnest, MDSearch for more papers by this author, James R. Adwers, MDSearch for more papers by this author, William D. Carey, MDSearch for more papers by this author, William J. Casarella, MDSearch for more papers by this author, Seymour Katz, MDSearch for more papers by this author, Peter M. Loeb, MDSearch for more papers by this author, David L. Nahrwold, MDSearch for more papers by this author, Seymour M. Sabesin, MDSearch for more papers by this author, James C. Thompson, MDSearch for more papers by this author, Jack A. Vennes, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-11-977 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExtracorporeal shock-wave lithotripsy potentially offers advantages as a treatment in selected patients with biliary tract stone disease. Representatives of the following eight professional societies (listed alphabetically) have prepared recommendations for training in gallstone lithotripsy: the American Association for the Study of Liver Disease, the American College of Gastroenterology, the American Gastroenterological Association, the American Society for Gastrointestinal Endoscopy, the American College of Radiology, the American College of Surgeons, the American Lithotripsy Society, and the Society for Surgery of the Alimentary Tract. Developed through a consensus process, the recommendations are based on data compiled from replies to a questionnaire about lithotripsy... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1991Volume 114, Issue 11Page: 977-979KeywordsBiliary systemDiagnostic radiologyEndoscopyGastroenterology and hepatologyInterleukinsLiver diseasesQuestionnairesSurgeonsSurgeryTreatment guidelines Issue Published: 1 June 1991 Copyright©1991 American College of PhysiciansPDF DownloadLoading ...
Sanfilippo A Syndrome SULFAMIDASE DEFICIENCY IN CULTURED SKIN FIBROBLASTS AND LIVER
Authors: Reuben Matalon, Albert Dorfman
Journal: Journal of Clinical Investigation (1974)

The Sanfilippo A syndrome is an autosomal recessive mucopolysaccharidosis characterized clinically by severe mental retardation and biochemically by storage in tissue and excretion in urine of excessive amounts of heparan sulfate. Since sulfamide groups are present in heparan sulfate, a sulfamidase deficiency could explain the impaired degradation of this polysaccharide. To investigate the enzymic basis of this disease, assays for sulfamidase were performed. Extracts of cultured fibroblasts and post-mortem liver were prepared by suspension of tissues in acetate: NaCl buffer, pH 4.5, containing Triton X-100 (Rohm and Haas Co., Philadelphia, Pa.), sonication, and centrifugation at 10,000 g. The supernatant fluid was incubated with [(35)S]-N-sulfated heparin. The release of inorganic sulfate after 18 h of incubation was determined by chromatography on Sephadex G-25. The liver and fibroblast extracts of patients with the Sanfilippo A syndrome showed a deficiency of sulfamidase. The quantity of heparan sulfate in fibroblasts derived from patients with Sanfilippo A, Hurler's and Hunter's diseases was found to be 7-10%, while it was about 1.25% of the total glycosaminoglycans in fibroblasts of normal controls.
Potential Role for Androgen-Deprivation Therapy and Pelvic Radiation Therapy in Node-Positive Postprostatectomy Prostate Cancer
Authors: David F. Jarrard, Michael L. Blute, Mark A. Ritter
Journal: Journal of Clinical Oncology (2014)

Article Tools ONCOLOGY GRAND ROUNDS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2014.57.8302 Journal of Clinical Oncology - published online before print October 20, 2014 PMID: 25332250 Potential Role for Androgen-Deprivation Therapy and Pelvic Radiation Therapy in Node-Positive Postprostatectomy Prostate Cancer David F. JarrardxDavid F. JarrardSearch for articles by this author Michael L. Blute JrxMichael L. Blute JrSearch for articles by this author , Mark A. RitterxMark A. RitterSearch for articles by this author Show More University of Wisconsin School of Medicine and Public Health; University of Wisconsin Carbone Comprehensive Cancer Center; and University of Wisconsin, Madison, WIUniversity of Wisconsin School of Medicine and Public Health; University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI https://doi.org/10.1200/JCO.2014.57.8302 First Page Full Text PDF Figures and Tables © 2014 by American Society of Clinical Oncology
Idiopathic giant oesophageal ulcer in an immunocompetent patient. The efficacy of thalidomide treatment
Authors: S OLLIVIER, J BONNET, M LEMANN, J-C COFFIN, R MODIGLIANI, R JIAN, P BERTHEAU, J-F FLEJOU
Journal: Gut (1999)

#### Background

Idiopathic oesophageal ulcers have only been described in patients with acquired immunodeficiency syndrome (AIDS). We report the first case occurring in an immunocompetent patient.

##### Case history

A 52 year old man presented with a one year history of odynophagia, retrosternal chest pain, dysphagia, and a 10 kg weight loss. He had no history of gastrointestinal disease and had not taken drugs. An upper endoscopy, performed shortly after symptom onset, showed a 3 cm solitary oesophageal ulcer with smooth and irregular margins 3 cm above the gastro–oesophageal junction. Biopsy samples showed acute and chronic inflammation without any fungal or viral particles. Despite three months on a proton pump inhibitor, symptoms and endoscopic findings did not change. Oesophageal manometry and pH metry were normal, and endoscopic …
A commitment to protect health and save lives
Authors: F. Godlee
Journal: BMJ (2012)

At what age are surgeons safest? In France, according to Antoine Duclos and colleagues, it’s between 35 and 50 years old (doi:10.1136/bmj.d8041). The authors looked prospectively at thyroid operations performed in five high volume centres and found an increased risk of permanent complications when operations were done by less experienced surgeons and those in practice for more than 20 years. This finding has a certain face validity, but the authors recommend caution in interpreting their results. They looked at only one type of operation and used a cross sectional …
Endoscopic submucosal dissection for residual rectal polyps embedded in tissue scar: a “rescue therapy” to prevent surgical intervention?
Authors: F. Azzolini, F. Biolchini, R. Sassatelli, L. Camellini, F. Decembrino, V. Iori, C. Tioli, G. Sereni, G. Bedogni
Journal: Endoscopy (2008)

The authors report a case of a 48-year-old Caucasian woman with a 3.5 cm residual polyp embedded in tissue scar, as a result of three endoscopic piecemeal resection sessions of a 10 cm sessile polyp of the lower rectum, previously diagnosed from biopsy as tubulous-villous adenoma with high-grade dysplasia.
Selection and “freedom” in biology and psychology
Authors: Julian C. Leslie
Journal: Behavioral and Brain Sciences (1999)

Rose provides a coherent account of how a number of simplifying assumptions apparently come together to support neurogenetic determinism, or “ultra-Darwinism.” This view, he demonstrates, is deeply flawed. He proposes instead that we must take account of the interaction of processes that determine our developmental trajectory at every stage. Unfortunately, he associates this defensible position with the claim that this gives freedom of action to humans. The implications of this for the interpretation of his general thesis are discussed.
Acute Pericarditis after Smallpox Vaccination
Authors: Vito F. Cangemi
Journal: New England Journal of Medicine (1958)

THE serous surfaces of the body are peculiarly sensitive to a variety of noxious agents so that their involvement is a common, and often the predominant, clinical feature of some other underlying pathologic process. The pericardium shares this characteristic, and it is therefore not surprising to find acute pericarditis in such diseases as rheumatic fever, bacterial infections and uremia. In a review of 96 cases of acute pericarditis Reeves1 reported rheumatic fever in 40.67 per cent, bacterial infections in 19.8 per cent, uremia in 11.5 per cent, benign nonspecific pericarditis of unknown etiology in 10.4 per cent, tuberculosis in 7.3 . . .
Lithium Carbonate for Recurrent Fever and Neutropenia
Authors: Robert H. Gerner
Journal: JAMA (1981)

THERE are several well-described, although not necessarily distinct, febrile, noninfectious, recurrent illnesses with normal-intervening intervals as follows: intermittent hydrarthrosis, familial Mediterranean fever (FMF), cyclic neutropenia (cyclic hematopoiesis), and periodic hypothalamic discharge. Although many of these disorders have been recognized for years, they are often misdiagnosed and frequently are discovered only after long and difficult diagnostic evaluation.<sup>1</sup>No specific origins characterize these disorders, and effective drug therapy is available for only two of these disorders: colchicine for FMF<sup>2</sup>and prednisone for cyclic neutropenia.<sup>3</sup>We report a case of recurrent fever and neutropenia that responded to therapy with lithium carbonate. The control of human body temperature is complicated and has recently been reviewed.<sup>4</sup>In patients with recurrent fevers, the following causes might be found: abnormal production or release of endogenous pyrogen from host phagocytic cells; abnormalities of the hypothalamic thermoregulatory center's response to endogenous pyrogen; or abnormalities of
764. RNA and Codon Optimized HIV Candidate Vaccines - from Bench to Clinical Trials
Authors: Ralf Wagner, Petra Mooij, Sunita Balla, Jens Wild, Kurt Bieler, Hans Wolf, Frank Notka, Jonathan Heeney, Giuseppe Pantaleo
Journal: Molecular Therapy (2005)

As recently demonstrated, extensive codon-usage modifications increased the overall GC content of late HIV transcripts by almost 30%, enhanced the nuclear stability of viral RNAs and resulted in a constitutive export of these RNAs into the cytoplasm. Besides, codon-usage modifications tremendously supported Rev-independent viral gene expression and significantly increased the safety of related vaccine constructs by reducing the risk for recombination events and avoiding untranslated 5' sequence elements that include otherwise indispensable and undesired packaging signals.
Review of child health targets shows progress, but coordination needs to improve
Authors: Susan Mayor
Journal: BMJ (2007)

The United Kingdom is improving its health services for children—particularly in specialised services such as neonatal care and mental health—and for pregnant women, a three year review has concluded. The review says that more resources and better coordination among service providers are needed to achieve the targets in a national 10 year plan for child health.

The review assessed progress in achieving the recommendations in the national service framework for children, young people, and maternity services, published in 2004, which set standards for all organisations that provide services to children.

Although the review found that the UK is one of the safest countries in the world in which to give birth, it calls for a greater focus on disadvantaged women and for …
Influence of Cyclosporin and Prednisolone on RAGE, S100A8/A9, and NFκB Expression in Human Keratinocytes
Authors: Nadia Djerbi, Piotr J. Dziunycz, Dominic Reinhardt, Guergana Iotzova-Weiss, Jürg Hafner, Severin Läuchli, Lars E. French, Günther F. L. Hofbauer
Journal: JAMA Dermatology (2013)
Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers
Authors: Andrea Boni, Pawel Muranski, Lydie Cassard, Claudia Wrzesinski, Chrystal M. Paulos, Douglas C. Palmer, Luca Gattinoni, Christian S. Hinrichs, Chi-Chao Chan, Steven A. Rosenberg, Nicholas P. Restifo
Journal: Blood (2008)
Radioiodine for Thyroid Cancer — Is Less More?
Authors: Erik K. Alexander, P. Reed Larsen
Journal: New England Journal of Medicine (2012)

In this issue of the Journal, Schlumberger et al.1 and Mallick et al.2 describe the administration of radioiodine (iodine-131) after total thyroidectomy in patients with low-risk thyroid cancer. Postsurgical treatment has long played an important role in the management of this increasingly common cancer.2 In the United States, the incidence nearly tripled (from 2.7 to 7.7 cases per 100,000) from 1973 through 2002.3 Similar increases have been reported in Europe.4 Such increases appear to result largely from more frequent radiologic detection and subsequent fine-needle aspiration of small thyroid nodules, leading to the diagnosis of low-risk thyroid cancer.Guidelines of the . . .
Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-center type B-cell lymphomas: a clinicopathologic analysis of cases included in the German BFM (Berlin-Frankfurt-Münster) Multicenter Trial
Authors: Ilske Oschlies, Wolfram Klapper, Martin Zimmermann, Matthias Krams, Hans-Heinrich Wacker, Birgit Burkhardt, Lana Harder, Reiner Siebert, Alfred Reiter, Reza Parwaresch
Journal: Blood (2006)
Microelectronics, radiation, and superconductivity.
Authors: M Gochfeld
Journal: Environmental Health Perspectives (1990)

Among the costs of technology are health hazards that face employees and consumers. New advances in the highly competitive field of microelectronics involve exposure to a variety of hazards such as gallium arsenide. Small high-technology industries appear unprepared to invest in health and safety. Although stray electromagnetic fields are not a new development, researchers are beginning to assemble data indicating that such fields pose a significant cancer risk under certain circumstances. Data have been obtained on fields associated with power lines on the one hand and consumer products on the other. Although not conclusive, the data are sufficient to warrant carefully designed research into the risks posed by electromagnetic fields. Because the scientific issues require research, there is a need to make basic social value decisions that will determine which technologies will be developed and which ones may be set aside because of their danger at the present time.
Arbitrariness and conventionality: actions speak louder than words
Authors: Emma Stapleton
Journal: BMJ (2007)

When patients present with balance symptoms, it's essential to find out exactly what their symptoms are. Patients complaining of dizziness could mean vertigo, dysequilibrium, light-headedness, presyncope, or something entirely different. And when patients report that they suffer from vertigo, there's every possibility that they're using the term to mean something other than the clinical definition—a sensation of spinning or motion.

When a deaf patient signs that he has vertigo he touches his index finger to his forehead, then moves his hand in small circles next to his head. The meaning is obvious. The intention is similarly clear when a deaf patient signs …
Susan Jean England Kerr
Authors: L. Foreman
Journal: BMJ (2003)

Former general practitioner Hampshire (b 1949; q Birmingham 1973), died from breast cancer on 2 October 2002.

After house jobs in Kidderminster and Portsmouth, Susan ran her father's general practice for five months when he had open heart surgery. A spell as a ship's surgeon on a refrigerated cargo ship to New Zealand introduced Sue to her future husband, chief engineer John Griffiths. She worked as a locum in many parts of New Zealand before returning to the United Kingdom and doing her vocational training. She eventually joined a practice covering Milford and some of Lymington on the edge of the New Forest. Sue was passionate about wildlife, flora, and fauna and was knowledgeable about fungi and orchids in particular. She leaves a husband, John, and two sons.
Progress in Medical Defense Against Nerve Agents
Authors: Michael A. Dunn
Journal: JAMA (1989)

For nearly 50 years, nerve agents have constituted a serious threat that has stimulated extensive efforts to develop effective medical countermeasures. Recent progress in producing pharmacologic defenses suggests that humans can be largely protected from the lethal and prolonged incapacitating effects of these compounds on a chemical battlefield. Current research on new approaches to binding and inactivating nerve agents may further decrease their potential as a threat against protected persons. (<i>JAMA</i>. 1989;262:649-652)
PELVIC TILT: RELIABILITY OF MEASURING THE STANDING POSITION AND RANGE OF MOTION IN ADOLESCENT ATHLETES
Authors: F Fourchet, O Materne, A Rajeb, C Horobeanu, A Farooq
Journal: British Journal of Sports Medicine (2014)

Background Standing pelvic posture remains a common assessment in sports therapy. The palpation technique assessing the relative position of the anterior and posterior superior iliac spines is widely used to quantify the asymmetry in pelvic position, but the reliability of this approach in adolescent athletes is not determined. Objective The aim of the present study was to examine the inter-rater and intra-rater reliability of palpation meter (PALM) measures for assessing standing pelvic tilt in adolescent athletes. Design Test-retest study. Setting Sports academy physiotherapy laboratory. Participants A group of highly-trained adolescent multi-sport athletes (n=75, age=14.9±1.7 yr) training in a national sports academy. Interventions On two occasions (10 min apart), two physiotherapists took the measurements of standing neutral pelvic tilt, anterior pelvic tilt and posterior pelvic tilt using the PALM. In each position an average of three measurements was taken by each examiner, alternatively for each side. Main outcome measurements: Reliability of standing pelvic tilt measures was assessed by calculating the between-session and the between-physiotherapists differences expressed as Cohen's d and the standard error of measurement (SEM: CV). Results All measured parameters showed good inter-rater and intra-rater reproducibility. The standardized differences between two trials or two physiotherapists was trivial with Cohen's d&lt;0.2 in each case. Most importantly the SEM was low when comparing measurements of neutral and anterior pelvic tilts positions between physiotherapists (CV≤15.8% and CV≤8.8% respectively) and between sessions (CV≤14.0% % and CV≤7.3% respectively), but not regarding posterior tilt position (CV≥38.9% between physiotherapists and CV≥24.8% between sessions). Conclusions The present method for assessing neutral and anterior standing pelvic tilt measurements has a good reliability level and may integrate longitudinal screening and clinical examination routines in young athletes. However, posterior pelvic tilt measurements should be cautiously interpreted due to lower measurements' reliability.
Phacomatosis pigmentokeratotica associated with hypophosphataemic rickets, pheochromocytoma and multiple basal cell carcinomas
Authors: J. Bouthors, M-C. Vantyghem, S. Manouvrier-Hanu, B. Soudan, E. Proust, R. Happle, F. Piette
Journal: British Journal of Dermatology (2006)
Evidence of Artemisinin-Resistant Malaria in Western Cambodia
Authors: Harald Noedl, Youry Se, Kurt Schaecher, Bryan L. Smith, Duong Socheat, Mark M. Fukuda
Journal: New England Journal of Medicine (2008)

To the Editor: Although artemisinins are potent and rapidly acting antimalarial drugs, their widespread use for treating patients with Plasmodium falciparum malaria raises the question of emerging drug resistance. 1,2Artemisinin monotherapy should not be used in areas where malaria is endemic; it requires an extended administration period and may lead to treatment failure, most frequently because of problems with compliance.Recent reports of high failure rates associated with artemisinin-based combination therapy, as well as in vitro drug-susceptibility data, suggest the possibility of clinical artemisinin resistance along the Thai-Cambodian border. 3,4 We studied the potential emergence of artemisinin resistance using in vivo, in vitro, molecular, and pharmacokinetic methods specifically designed to address the question of potential artemisinin resistance.We randomly assigned, in a ratio of 2:1, 94 adults from Battambang Province presenting with uncomplicated P. falciparum malaria (100 to 100,000 parasites per microliter) to receive either highdose artesunate therapy (4 mg per kilogram of body weight per day, orally, for 7 days) (60 pa-