tbuckley/cabot-search huggingface dataset:
Cardiac atria and ventricles contain different inducible adrenaline synthesising enzymes
Authors: H H Elayan, B P Kennedy, M G Ziegler
Journal: Cardiovascular Research (1990)

Study objective – The aim of the study was to investigate adrenaline synthesis in atrial and ventricular homogenates. Design – The study involved the use of a new assay which measures the rate at which tissue homogenates convert noradrenaline into adrenaline, or dopamine into N-methyldopamine. This was coupled with a sensitive assay for tissue catecholamines in an investigation of ventricular and atrial homogenates from rats exposed to adrenal demedullation and chemical depletion of cardiac catecholamines. Measurements and results – Atrial and ventricular homogenates from 12 male Sprague-Dawley rats were investigated. Atrial adrenaline forming activity resembled adrenal phenylethanolamine-N-methyltransferase (PNMT) in its relatively high affinity for noradrenaline, substrate specificity for noradrenaline over dopamine, and inhibition by the PNMT inhibitor SKF 29661. Ventricular tissue non-specifically methylated both noradrenaline and dopamine, and was less inhibited by SKF 29661. Adrenal demedullation induced activity of ventricular adrenaline forming enzyme. Conclusions – The cardiac atria and ventricles contain different inducible adrenaline forming enzymes. About one third of cardiac adrenaline may be synthesised by the heart itself. The ventricular enzyme can synthesise adrenaline from noradrenaline, and N-methyldopamine from dopamine.
Management of recurrent malignant pleural effusion in the United Kingdom: survey of clinical practice.
Authors: L G McAlpine, G Hulks, N C Thomson
Journal: Thorax (1990)

Malignant pleural effusions are often symptomatic and tend to recur after simple aspiration. Pleurodesis may prevent recurrence of the effusion; many agents and techniques have been described. A questionnaire was sent to 448 clinicians in the United Kingdom to determine how pleurodesis is performed in practice. There was a 56% overall response, with replies from 101 respiratory physicians, 88 general physicians, 29 thoracic surgeons, and 35 general surgeons. General surgeons saw few cases of malignant pleural effusion and rarely performed pleurodesis. A patient with recurrent malignant pleural effusion would usually be managed with pleurodesis by 76 (76%) respiratory physicians, 26 (30%) general physicians, and 23 (81%) thoracic surgeons; a further 29 (33%) general physicians would refer such patients to another specialist. Most medical pleurodesis were performed by junior staff, whereas consultant thoracic surgeons were more likely to be concerned with the procedure. All the thoracic surgeons used an intercostal tube drain, usually with suction. An intercostal tube drain was used routinely by only 54 (54%) of the respiratory physicians and 28 (32%) general physicians. Thoracic surgeons preferred talc for pleurodesis whereas physicians most commonly used tetracycline. The variety of methods in use supports the need for randomised, controlled studies to determine the most effective technique of pleurodesis.
Precipitation of Verapamil in an Intravenous Line
Authors: ROBERT TUCKER
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 December 1984Precipitation of Verapamil in an Intravenous LineROBERT TUCKER, M.S., R.Ph., JOHN F. GENTILE, M.D.ROBERT TUCKER, M.S., R.Ph.Search for more papers by this author, JOHN F. GENTILE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-6-880_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a letter in the October 1982 issue, Bar-Or and associates (1) reported a case in which an intravenous line of 0.45% NaCl was established. Sodium bicarbonate had been added to the primary intravenous solution and verapamil, 5 mg, was injected through the intravenous line. An immediate precipitate was seen in the line distal to the point of injection.We wish to report a similar incident with verapamil injection in a patient at our institution with the antibiotic nafcillin sodium (Unipen; Wyeth Laboratories; Philadelphia, Pennsylvania). Precipitation occurred on three occasions involving three different...References1. BAR-ORKULIGMARXROSEN DKJP. Precipitation of verapamil [Letter]. Ann Intern Med. 1982;97:619. LinkGoogle Scholar2. CUTIE M. Verapamil precipitation [Letter]. Ann Intern Med. 1983;98:672. LinkGoogle Scholar3. CUTIE M. Compatibility of verapamil hydrochloride injection with commonly used additives. Am J Hosp Pharm. 1982;40:1205-7. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pontiac General Hospital Pontiac, MI 48053 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPlasma Compatibility of Injectables: Comparison of Intravenous U-74006F, a 21-Aminosteroid Antioxidant, with Dilantin Brand of Parenteral Phenytoin 1 December 1984Volume 101, Issue 6Page: 880-880KeywordsAntibioticsBicarbonatesRisk managementSodiumSodium chloride Issue Published: 1 December 1984 PDF downloadLoading ...
Adult Fibroelastosis with Congenital Tricuspid Stenosis
Authors: EDGAR V. ALLEN, RAYMOND D. PRUITT, HANS POPPER, DANIEL S. KUSHNER, BENJAMIN GASUL
Journal: Circulation (1956)

as one of the regular weekly clinical-pathologic exercises of the Hospital.The conferences are modeled after the Cabot prototype, the case being presented by the clinicians as an unknown for discussion.In order to preserve the spirit and spontaneity of the original conference, editing has been limited largely to making the material more suitable for publication, selection of pertinent photomicrographs for reproduction, and docu- mentation of pathologic interpretations by appropriate references.CLINICAL DATA AND DiScUSSION DR.BENJAMIN GASUL: A 39-year-old Ameri- can-born married white male clerk was ad- mitted to Cook County Hospital in November 1954 with complaints of blueness, severe short- ness of breath, marked weakness, abdominal distention, and incoherence for 1 day.He had been well until 1951, when he had the first episode leading to 4 admissions to another hos- pital, summarized as follows:October 1951.The patient's right foot sud- denly became cold, blue, and pulseless.An embolectomy was performed but gangrene en- sued and a supracondylar femoral amputation was done.Perhaps we should stop to analyze this very serious mode of onset of illness.This man, perfectly well for 36 years, suddenly de- veloped a cold, blue, pulseless foot.This could mean arteriosclerosis with a local thrombus, a thromboangiitis obliterans, or a diabetic arterio-
Right ventricular hypertrophy is an important determinant of right ventricular infarction complicating acute inferior left ventricular infarction
Authors: Mervyn B. Forman, B. Hadley Wilson, James R. Sheller, Harry A. Kopelman, William K. Vaughn, Renu Virmani, Gottlieb C. Friesinger
Journal: Journal of the American College of Cardiology (1987)
Language and the Physician's Art
Authors: Sydney Louis
Journal: JAMA (1979)

OUR goal is to characterize the alteration in attitudes toward physicians during the last 20 to 30 years as reflected in some of the patterns of language usage regarding "the physician." Much of the world is perceived through the categories of our language, and the realities in that world are bound up in a nexus of words. The words we use to mark off the reality of the physician set up linkages with ideas and images and hence may come to re-create in our belief, thought, and action new realities and a new vocabulary of the physician. These new words and the new reality to which the physician is bound reflect the many social, cultural, and historical changes that have occurred since World War II and have already come to modify behavior and patterns of expectation regarding the physician. <h3>The Physician as Healer</h3> The<i>Random House Dictionary</i>defines "physician" as
Tories want to free NHS of political interference
Authors: Michael Day
Journal: BMJ (2007)

The Conservative party plans to free the health service from political interference by handing over control of the day to day running of the NHS in England to an independent NHS board.

The radical plan appears in a white paper that will form the basis of the party's health policy at the next general election.

Launching the document last week, the Tory leader David Cameron said that, in addition to the planned NHS board, a pledge to scrap national targets and devolve more power to doctors would further enhance the independence of the NHS.

The shadow health secretary, Andrew Lansley, said, “We need a service where the government …
Altered left atrial compliance after atrial appendectomy. Influence on left atrial and ventricular filling.
Authors: B D Hoit, Y Shao, L M Tsai, R Patel, M Gabel, R A Walsh
Journal: Circulation Research (1993)

Previous studies have shown regional differences in atrial distensibility. We studied 12 open-chest dogs to test the hypothesis that left atrial compliance is decreased after removal of the left atrial appendage and to determine the effect of altered atrial compliance on atrial reservoir and conduit function. Sonomicrometer crystal pairs were used to measure the long- and short-axis diameters of the left atrium over a wide range of intracardiac pressures and volumes obtained by intravenous hetastarch infusion both before and after suture ligation of the left atrial appendage (appendectomy). Pulmonary venous flow was measured with an ultrasonic flowmeter, and transmitral flow velocities were measured with transesophageal Doppler echocardiography. After appendectomy, the diastolic pressure-volume relation was shifted upward and to the left in six of seven dogs. The mean dynamic stiffness constant of the left atrial diastolic pressure-volume relation was significantly greater after appendectomy than before (0.20 +/- 0.11 [mean +/- SD] versus 0.14 +/- 0.08 ml-1, p &lt; 0.01); the mean y intercept was slightly, but significantly, less after appendectomy (0.6 +/- 0.3 versus 1.3 +/- 0.6 mm Hg, p &lt; 0.05). The left atrial reservoir volume (maximum minus minimum left atrial volume) was significantly less after appendectomy at matched left atrial pressures. The systolic to diastolic flow integral ratio of pulmonary venous flow (JFTI/KFTI), an index of the relative reservoir to conduit functions of the left atrium, increased significantly with volume infusion only before appendectomy; at matched left atrial pressure, JFTI/KFTI was significantly less afterwards.(ABSTRACT TRUNCATED AT 250 WORDS)
The suitability of sunglasses used by patients following ingestion of psoralen
Authors: H. MOSELEY, N.H. COX, R.M. MACKIE
Journal: British Journal of Dermatology (1988)

We have investigated the types of eyewear which patients on photochemotherapy have obtained, and determined their suitability for providing adequate protection. Fifty-eight pairs of sunglasses from 53 patients were assessed. Spectral transmission was measured between 200 nm and 800 nm at 10 nm intervals. Thirty-eight pairs of glasses (66%) were found to be satisfactory. Particularly high UV transmission was recorded in 11 cases (19%), highlighting the need for increased awareness of the problem of ensuring that suitable protective eyewear is used.
Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia
Authors: Hong-Hu Zhu, Ya-Zhen Qin, Xiao-Jun Huang
Journal: New England Journal of Medicine (2014)

Although resistance to arsenic trioxide in patients with acute promyelocytic leukemia is very rare, mutations in PML at the site of arsenic binding appears to be the main mechanism of resistance.
Double-blind Trial of Linoleate Supplementation of the Diet in Multiple Sclerosis
Authors: J. H. D. Millar, K. J. Zilkha, M. J. S. Langman, H. P. Wright, A. D. Smith, J. Belin, R. H. S. Thompson
Journal: BMJ (1973)

Seventy-five patients in London and Belfast with multiple sclerosis were given daily supplements of a vegetable oil mixture containing either linoleate or oleate for two years in a double-blind control trial. Relapses tended to be less frequent and were significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.
Mechanisms of antibody-dependent cellular cytotoxicity: the use of effector cells from chronic granulomatous disease patients as investigative probes.
Authors: P Katz, C B Simone, P A Henkart, A S Fauci
Journal: Journal of Clinical Investigation (1980)

The present study characterized the antibody-dependent cellular cytoxicity (ADCC) of leukocyte effector cells (neutrophils, lymphocytes, and monocytes) from normal subjects and from chronic granulomatous disease (CGD) patients. CGD phagocytic cells (neutrophils and monocytes) had depressed ADCC activity against antibody-coated human erythrocyte (HRBC) targets in suspension cultures indicative of abnormal intracellular postphagocytic killing. However, when phagocytosis was prevented by using a monolayer of antibody-coated HRBC targets, CGD monocytes, neutrophils, and lymphocytes exhibited normal ADCC activity. Similarly, antibody-coated HRBC targets in suspension could be lysed normally by CGD effector cells when phagocytosis was inhibited by the addition of in vitro colchicine. Extracellular lysis of autologous antibody-coated lymphoid cell targets in suspension was mediated normally by CGD effector cells. Thus, standard ADCC against HRBC targets in suspension is predominantly indicative of postphagocytic killing and, as such, is dependent upon a normal post-phagocytic respiratory burst of oxidative metabolism which is deficient in CGD neutrophils and monocytes. Extracellular killing of sensitized targets does not appear to be dependent upon the generation of hydrogen peroxide (H2O2) ANd/or superoxide (02-) and is normal in CGD neutrophils and monocytes. Hence, by employing CGD leukocytes as investigative probes in ADCC, fundamental mechanisms of intracellular vs. extracellular expression of cytotoxicity have been delineated.
Hypofibrinogenemia in Scrub Typhus
Authors: David Chernof
Journal: New England Journal of Medicine (1967)

HYPOFIBRINOGENEMIA has recently been demonstrated in Rocky Mountain spotted fever.1 This report documents hypofibrinogenemia in another rickettsial disease, scrub typhus.A 22-year-old man was admitted, to the 85th Evacuation Hospital, South Vietnam, on June 15, 1966, with a 4-day history of fever. A blood smear revealed plasmodia (species unidentified), and quinine and pyrimethamine (Daraprim) were given. Despite continuation of quinine he remained febrile upon arrival at the United States Army Hospital, Camp Zama, Japan on June 22.On admission the temperature was 104°F., the pulse 80, and the respirations 18. The blood pressure was 110/70. There was an erythematous maculopapular . . .
Artificial insemination by donor.
Authors: J S Scott
Journal: BMJ (1973)

be traced.Thus the work of Bernstein and others in Britain and America on the importance of early language stimulation, with which we are fully familiar, is not applicable to the present group of children.May we suggest that all of us who are genuinely concerned with language develop- ment in young children join together in tackling this important problem rather than widening divisions of opinion by criticizing large-scale screening procedures in a national survey which, though inevitably crude, did produce useful information hitherto unavail- able.-Weare, etc.
USEFULNESS OF BIOMARKERS FOR PROGNOSTICATION OF OUTCOME WITH EARLY INVASIVE OR NONINVASIVE TREATMENT IN NON-ST-ELEVATION ACUTE CORONARY SYNDROMES &amp;ndash; A SUBSTUDY FROM THE PROSPECTIVE RANDOMIZED PLATELET INHIBITION AND PATIENT OUTCOMES (PLATO) TRIAL
Authors: Lars Wallentin, Stefan James, Evangelos Giannitsis, Hugo Katus, Richard Becker, Christopher Cannon, Jan cornel, H&aring;kan Emanuelsson, Steen Husted, Robert Harrington, Philippe Steg, Robert Storey, Lisa Wernroth, Agneta Siegbahn
Journal: Journal of the American College of Cardiology (2012)
The relation between reproductive and reconstructive processing of memory content
Authors: Harry P. Bahrick
Journal: Behavioral and Brain Sciences (1996)

Abstract Quantitative losses of memory content imply replicative processing; correspondence losses imply reconstructive processing. Research should focus on the relationship between these processes by obtaining accuracy- and quantity-based indicators of memory within the same framework. This approach will also yield information about the effects of task and individual-difference variables on loss and distortion, as well as the time course of each process.
CELERY ITCH: DERMATITIS DUE TO CELERY IN VEGETABLE CANNING.
Authors: S. A. HENRY
Journal: British Journal of Dermatology (1933)

Journal Article CELERY ITCH: DERMATITIS DUE TO CELERY IN VEGETABLE CANNING. Get access S. A. HENRY, M.A., M.D.Cantab., D.P.H.Cantab. S. A. HENRY, M.A., M.D.Cantab., D.P.H.Cantab. H.M. Medical Inspector of Factories Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 45, Issue 7, 1 July 1933, Pages 301–309, https://doi.org/10.1111/j.1365-2133.1933.tb10182.x Published: 01 July 1933
Evaluation of hepatitis B virus polymerase gene mutations in hepatitis-B-E-antigen-negative patients receiving lamivudine therapy
Authors: H. Akkiz, Y. Ergun, M. Sandikci, S. Colakoglu, M. Serin, M. Oksuz, F.Y. Isiksal, F. Kocak, B. Abayli
Journal: Journal of Hepatology (2003)
Prostaglandins inhibit renal ammoniagenesis in the rat.
Authors: E R Jones, T R Beck, S Kapoor, R Shay, R G Narins
Journal: Journal of Clinical Investigation (1984)

We describe the inhibitory effect of prostaglandins (PGs) on in vivo rat renal ammonia synthesis. The influence of systemic pH upon urinary PG excretion and ammoniagenesis was also investigated. Finally, PG production by incubated rat renal cortical slices was suppressed to investigate the PG-ammonia interplay in the absence of changes in renal blood flow, glomerular filtration rate, ambient electrolyte concentrations or extrarenal hormonal factors. In vivo ammonia synthesis doubled and PG excretion fell by 44% in normal rats, after intravenous administration of 1 mg/kg of meclofenamate. Higher doses of meclofenamate further augmented ammonia production and further reduced PG excretion. PG depletion was also associated with an increase in fractional excretion of ammonia (FENH3) that was independent of changes in urine flow rate or pH. Acute metabolic acidosis (AMA) increased total ammonia synthesis but also stimulated PG production. Administration of meclofenamate to rats with mild AMA markedly reduced urinary PG excretion, further augmented ammonia synthesis, and significantly increased the FENH3. Inhibition of stimulated PG synthesis during severe AMA did not increase ammoniagenesis or FENH3. Acute metabolic alkalosis did not alter production of PGs or ammonia, but reduced the FENH3 by 42%. Meclofenamate nearly normalized the FENH3 but stimulated synthesis to a lesser degree than was seen in nonalkalotic rats that received meclofenamate. Inhibition of PG synthesis in incubated rat renal cortical slices also stimulated ammoniagenesis. Conversely, stimulation of PG synthesis decreased ammonia production and acidification of the incubation medium increased prostaglandin F2 alpha production. Thus, in vitro findings support the in vivo results. We conclude that PGs inhibit ammonia synthesis in normal rats and in those undergoing mild AMA. Severe acidosis overrides this inhibitory effect of PGs, whereas metabolic alkalosis suppresses the stimulatory effect of PG synthesis inhibition.
Nucleotide regulation of ATP sensitive potassium channels
Authors: A. Terzic, R. T Tung, Y. Kurachi
Journal: Cardiovascular Research (1994)

Journal Article Nucleotide regulation of ATP sensitive potassium channels Get access André Terzic, André Terzic Division of Cardiovascular Diseases, Department of Internal Medicine, Guggenheim 7F, Mayo Clinic, Rochester, MN 55905, IJSA: A Terzic, R T Tung, Y Kurachi. Correspondence to Dr Kurachi. Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert T Tung, Robert T Tung Division of Cardiovascular Diseases, Department of Internal Medicine, Guggenheim 7F, Mayo Clinic, Rochester, MN 55905, IJSA: A Terzic, R T Tung, Y Kurachi. Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshihisa Kurachi Yoshihisa Kurachi Division of Cardiovascular Diseases, Department of Internal Medicine, Guggenheim 7F, Mayo Clinic, Rochester, MN 55905, IJSA: A Terzic, R T Tung, Y Kurachi. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 6, June 1994, Pages 746–753, https://doi.org/10.1093/cvr/28.6.746 Published: 01 June 1994 Article history Received: 16 December 1993 Accepted: 28 January 1994 Published: 01 June 1994
Acquired Aplastic Anemia
Authors: Neal S. Young
Journal: Annals of Internal Medicine (2002)

In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes. The aberrant immune response may be triggered by environmental exposures, such as to chemicals and drugs or viral infections and, perhaps, endogenous antigens generated by genetically altered bone marrow cells. In patients with post-hepatitis aplastic anemia, antibodies to the known hepatitis viruses are absent; the unknown infectious agent may be more common in developing countries, where aplastic anemia occurs more frequently than it does in the West. The syndrome paroxysmal nocturnal hemoglobinuria (PNH) is intimately related to aplastic anemia because many patients with bone marrow failure have an increased population of abnormal cells. In PNH, an entire class of proteins is not displayed on the cell surface because of an acquired X-chromosome gene mutation. The PNH cells may have a selective advantage in resisting immune attack. In contrast, the disease myelodysplasia can be confused with aplasia and can also evolve from aplastic anemia. The occurrence of cytogenetic abnormalities in patients years after presentation implies that genomic instability is a feature of this immune-mediated disease. Aplastic anemia can be effectively treated by stem-cell transplantation or immunosuppressive therapy. Transplantation is curative but is best used for younger patients who have histocompatible sibling donors. Antithymocyte globulin and cyclosporine restore hematopoiesis in approximately two thirds of patients. However, recovery of blood cell count is often incomplete, recurrent pancytopenia requires retreatment, and some patients develop late complications (especially myelodysplasia).
Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils
Authors: Shinji Higa, Toru Hirano, Mayumi Kotani, Motonobu Matsumoto, Akihito Fujita, Masaki Suemura, Ichiro Kawase, Toshio Tanaka
Journal: Journal of Allergy and Clinical Immunology (2003)
A HEIGHTENED PLATELET RESPONSE TO CLOPIDOGREL BY POINT-OF-CARE TESTING PREDICTS BLEEDING OUTCOMES IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION. RESULTS OF ARMYDA-BLEEDS (ANTIPLATELET THERAPY FOR REDUCTION OF MYOCARDIAL DAMAGE DURING ANGIOPLASTY-BLEEDING STUDY)
Authors: Elisabetta Ricottini, Giuseppe Patti, Vincenzo Vizzi, Annunziata Nusca, Domenico Grieco, Vincenzo Pasceri, Germano Di Sciascio
Journal: Journal of the American College of Cardiology (2011)