Hydroxyurea-Induced Leg Ulcers Treated with Apligraf
Authors: Francisco Flores, William A. Eaglstein, Robert S. Kirsner
Journal: Annals of Internal Medicine (2000)

Letters7 March 2000Hydroxyurea-Induced Leg Ulcers Treated with ApligrafFrancisco Flores, MD, William A. Eaglstein, MD, and Robert S. Kirsner, MDFrancisco Flores, MDUniversity of Miami; Miami, FL 33136 (Flores)University of Miami; Miami, FL 33136 (Eaglstein)University of Miami; Miami, FL 33136 (Kirsner), William A. Eaglstein, MDUniversity of Miami; Miami, FL 33136 (Flores)University of Miami; Miami, FL 33136 (Eaglstein)University of Miami; Miami, FL 33136 (Kirsner), and Robert S. Kirsner, MDUniversity of Miami; Miami, FL 33136 (Flores)University of Miami; Miami, FL 33136 (Eaglstein)University of Miami; Miami, FL 33136 (Kirsner)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-5-200003070-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hydroxyurea is an antineoplastic agent commonly used to treat myeloproliferative disorders. We report on a 74-year-old woman with a history of chronic myelocytic leukemia who was treated with hydroxyurea. During therapy, the patient developed a cutaneous ulcer on her right lateral malleolus that was accompanied by severe pain and burning at the ulcer site. Malleoli ulcers have been uncommonly reported in patients receiving hydroxyurea (1, 2). Postulated mechanisms of hydroxyurea-induced ulcers include inhibition of DNA synthesis and subsequent keratinocyte cell death. A typical feature of hydroxyurea-induced ulcer is a poor response to standard ulcer therapeutic agents, such ...References1. Best PJ, Daoud MS, Pittelkow MR, Petitt RM. Hydroxyurea-induced leg ulceration in 14 patients. Ann Intern Med. 1998;128:29-32. LinkGoogle Scholar2. Weinlich G, Schuler G, Greil R, Kofler H, Fritsch P. Leg ulcers associated with long-term hydroxyurea therapy. J Am Acad Dermatol. 1998;39:372-4. CrossrefMedlineGoogle Scholar3. Eaglstein WH, Falanga V. Tissue engineering and the development of Apligraf, a human skin equivalent. Clin Therapeutics. 1997;19:894-905. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Francisco Flores, MD; William A. Eaglstein, MD; Robert S. Kirsner, MDAffiliations: University of Miami; Miami, FL 33136 (Flores)University of Miami; Miami, FL 33136 (Eaglstein)University of Miami; Miami, FL 33136 (Kirsner) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAtorvastan, Apsirin and Hydorxyurea for an Effective and Low-Cost Treatment in High-Risk Polycythemia VeraCommon, But Neglected: A Comprehensive Review of Leg Ulcers in Sickle Cell DiseaseAtypical wounds. Best clinical practice and challengesLeg ulcer induced by hydroxycarbamide in sickle cell disease: What is the therapeutic impact?The Role of Stem Cell Therapeutics in Wound HealingCutaneous ulcers associated with hydroxyurea therapyAtypical ulcersEmerging Adverse Cutaneous Drug ReactionsA multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinomaUlzerationen unter Therapie mit HydroxyharnstoffA Case Report of the Eradication of Pseudomonas aeruginosa from Leg Ulcer in a Patient with Essential ThrombocythemiaThe role of fibroblasts in tissue engineering and regenerationA review of a bi-layered living cell treatment (Apligraf�) in the treatment of venous leg ulcers and diabetic foot ulcersUpdate on Tissue-Engineered Biological DressingsUpdate on Tissue-Engineered Biological DressingsCutaneous Tissue Engineering and Lower Extremity Wounds (Part 2)Leg ulcer in a patient associated with hydroxyurea therapyHydroxyurea-Induced Skin Ulcerations in Patients with Chronic Myeloproliferative DisordersEvaluation of Tissue-Engineered Skin (Human Skin Substitute) and Secondary Intention Healing in the Treatment of Full Thickness Wounds after Mohs Micrographic or Excisional SurgeryEvaluation of Tissue-Engineered Skin (Human Skin Substitute) and Secondary Intention Healing in the Treatment of Full Thickness Wounds after Mohs Micrographic or Excisional SurgeryEffective Management of Difficult Surgical Defects Using Tissue-Engineered SkinEffective Management of Difficult Surgical Defects Using Tissue-Engineered SkinEffective Management of Difficult Surgical Defects Using Tissue-Engineered SkinCurrent AwarenessHydroxycarbamide 7 March 2000Volume 132, Issue 5Page: 417-418KeywordsAntibioticsChemotherapyChronic myelocytic leukemiaDNA synthesisFood and Drug AdministrationKeratinocytesMyeloproliferative disordersPainPatient advocacyUlcers ePublished: 15 August 2000 Issue Published: 7 March 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...