tbuckley/cabot-search huggingface dataset:
Prevalence of Alcohol and Other Drug Problems Among Physicians
Authors: Joan M. Brewster
Journal: JAMA (1986)

Extreme statements regarding the prevalence of problems with alcohol and other drugs among physicians have often been made without firm empirical support. The data that are available can be categorized as follows: license and disciplinary actions, known or registered addicts, mortality rates, hospital admissions and treatment populations, and surveys of selected groups of physicians. Because of difficulties in interpreting each type of data, it must be concluded that the prevalence of drug problems among physicians is unknown. A previously unpublished survey of Ontario physicians found that the proportion who have been treated for problems with alcohol and other drugs is not greater than that in the general population. Indeed, when alcohol and other drugs are considered together, physicians may not be unusually likely to have such problems.
SUPRALIMUS™ BIOABSORBABLE-POLYMER SIROLIMUS-ELUTING STENT TECHNOLOGY IN PATIENTS WITH ACUTE CORONARY SYNDROME: TWO-YEAR RESULTS OF THE PROSPECTIVE, MULTICENTER, E-SERIES REGISTRY.
Authors: Jose de Ribamar Costa, Alexandre Abizaid, Bruno Machado, Maurício Prudente, Pritesh Parikh, George Ximenes, Edmur Araújo, álvaro Matheus, Ricardo Costa, Fausto Feres, Andréa Abizaid, Expedito Ribeiro, None on behalf of E-SERIES investigators
Journal: Journal of the American College of Cardiology (2010)
The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages
Authors: Taylor W. Starnes, David A. Bennin, Xinyu Bing, Jens C. Eickhoff, Daniel C. Grahf, Jason M. Bellak, Christine M. Seroogy, Polly J. Ferguson, Anna Huttenlocher
Journal: Blood (2014)
Abstract 4806: Breast carcinoma DNA methylation profiles are associated with tumor size, alcohol intake, and folate intake
Authors: Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman, Carmen J. Marsit, Shichun Zheng, Margaret R. Wrensch, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas, Lawrence H. Kushi, Marilyn L. Kwan, John K. Wiencke
Journal: Cancer Research (2010)

Abstract The cornerstones of breast cancer prognosis and management are tumor size and axillary lymph node involvement. We investigated both individual genes and overall patterns of methylation in relation to these and other tumor characteristic along with environmental exposure variables. The Illumina GoldenGate methylation bead-array platform was used to measure 1413 autosomal CpG loci associated with 773 cancer-related genes in 162 FFPE primary breast tumors (AJCC stage I-IV) from the Pathways Study. From CpG locus-by-locus tests, the strongest methylation associations (based on the number of CpG loci with Q-values &amp;lt; 0.05) were for tumor grade (209 loci), tumor size (74 loci), estrogen receptor status (183 loci), progesterone receptor status (69 loci), and triple negative status (130 loci). Unsupervised clustering, using a recursively partitioned mixture model (RPMM), of all autosomal CpG loci across all tumors resulted in eight distinct methylation profile classes, and class membership was significantly associated with patient race (P &amp;lt; 0.02) and tumor size (P &amp;lt; 0.001). Using multinomial logistic regression to adjust for potential confounders, patient age, alcohol intake, total dietary folic acid intake, and tumor size were all significantly associated with tumor methylation profile (all P &amp;lt; 0.0001). Furthermore, there were opposite trends of methylation for increasing alcohol and folate intake, which were associated with decreased and increased methylation, respectively. Lymph node status, tumor grade, estrogen receptor status and tumor histology were not associated with methylation class in the multinomial model. In an RPMM of tumors from postmenopausal patients only, methylation class membership was significantly associated with estrogen receptor status (P &amp;lt; 0.03). Selected CpG loci were validated with Sequenom EpiTYPER methylation analysis and methylation of several candidate genes were associated with silencing of gene expression. Taken together, these data demonstrate strong associations between both specific gene methylation and overall DNA methylation profiles and tumor characteristic and patient exposure history. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4806.
THE DIAGNOSIS OF PHTHISIS
Authors: F. Rees
Journal: BMJ (1916)

I~~~-M ICAL JOUnN'-AL far as I can renmember, a single failure.The procedure was also circulated by the then Surgeon-General for the information aud guidance of all medical officers I must, lhowever, state that when I first came home fromii India in 1905 fxng-3skin grafting by my method (whlich is that now described by Captain Kendall) was given a trial at the Radcliffe Infirmary in Oxford by one of the surgeons, Lieutenant-Colonel Dodds-Parker, now senior surgeon of the 3id Southern General Hospital, which I have the honour to command.It proved a complete failure.In my opinion this failure resulted from the epidermal cells of the British frog failing to accommodate themselves to the normal body temperature of the human being.In this view tlhe 1ate Professor Jenkinson of this university concured, and he made experiments to endeavour to aceclimatize tadpoles to the abnormally high temperature, but withont success.It is encouraging to learn that Captain Kendall has met witlh success in his frog skin in France, in view of the failure witlh English frogs above mentioned.-Iam, etc.,
Gastrointestinal complications of pelvic radiotherapy: are they of any importance?
Authors: J Andreyev
Journal: Gut (2005)

Radiation induced bowel damage affects 6000 individuals annually in the UK, with a negative impact on quality of life. Our understanding of how to treat these patients is dismally lacking an evidence base. Fibrosis seems to be the unifying underlying cause for most symptoms. Progress in understanding the development and treatment of fibrosis in these patients might have important consequences for patients with other causes of fibrosis in the gastrointestinal tract
1000 Genomes Project Finds Substantial Genetic Variation Among Populations
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Research on the Fetus
Authors: Thomas D. Maher
Journal: JAMA (1974)

To the Editor.—  The COMMENTARY covered everything from German measles to the Scopes trial—everything, that is, except abortus research.  The investigators in the Boston case ( New Engl J Med 288:1219, 1973) administered drugs to human fetuses in utero, drugs that were therapeutic neither for mother nor fetus. Proposed National Institutes of Health guidelines would prohibit such activity, but not autopsies and not organ or tissue donation. The Helsinki Declaration restricted nontherapeutic research on live human subjects, particularly those in a dependent position, when the research is harmful. The issue, then, is whether we are going to violate this principle in the name of progress.
APPENDICITIS OBLITERANS.Read before the Chicago Academy of Medicine, March 16, 1894.
Authors: N. SENN
Journal: JAMA (1894)

The successful surgical treatment of peritonitis caused by infective lesions of the appendix vermiformis constitutes the most brilliant chapter of modern aggressive surgery. The surgeons have taught physicians by scientific research, as well as by lessons learned from clinical experience, that peritonitis, in the majority of cases, is a secondary affection, and that its successful treatment depends largely upon the detection and removal of the primary cause. The present large amount of knowledge concerning appendicitis and its complications is largely the result of the work of American surgeons. The European surgeons are slow in accepting the teachings and practice, as developed and promulgated in this country, but in the near future they will have to submit to the most convincing proof—the results of clinical experience. During the last five years so much literature on the surgical treatment of inflammatory affections of the appendix has accumulated that this subject has become
Absence of oats toxicity in adult coeliac disease
Authors: U. Srinivasan, N. Leonard, E. Jones, D. D Kasarda, D. G Weir, C. O'Farrelly, C. Feighery
Journal: BMJ (1996)

Incidence of acute lymphoblastic leukaemia in young children increased with the "entropy" attributable to migration into their districts of resi- dence * Population mixing even at relatively low levels may be important in the aetiology of childhood leukaemia * The results provide further epidemiological evi- dence that childhood leukaemia might be a rare response to infection * Previous studies finding increased incidence in more affluent areas may have been indirectly observing a population mixing effect SOCIOECONOMIC STATUSWe are grateful to regional cancer registries, regional children's tumour registries, the UK Children's Cancer Study Group, the Clinical Trial Service Unit, and OPCS for providing notifications of cases of childhood leukaemia.We thank the many people who have worked on the National Registry of Childhood Tumours, particularly
Identification of Cyclin B1 as a Shared Human Epithelial Tumor-Associated Antigen Recognized by T Cells
Authors: Henry Kao, Jarrod A. Marto, Thomas K. Hoffmann, Jeffrey Shabanowitz, Sydney D. Finkelstein, Theresa L. Whiteside, Donald F. Hunt, Olivera J. Finn
Journal: The Journal of Experimental Medicine (2001)

We eluted peptides from class I molecules of HLA-A2.1(+) breast adenocarcinoma and loaded reverse phase high-performance liquid chromatography (HPLC) fractions onto dendritic cells to prime naive CD8(+) T cells. Fractions that supported growth of tumor-specific cytotoxic T lymphocytes were analyzed by nano-HPLC micro-ESI tandem mass spectrometry. Six HLA-A2.1-binding peptides, four 9-mers (P1-P4) differing in the COOH-terminal residue, and two 10-mers (P5 and P6) with an additional COOH-terminal alanine, were identified in one fraction. Peptide sequences were homologous to cyclin B1. We primed CD8(+) T cells from another HLA-A2.1(+) healthy donor with synthetic peptides and generated P4-specific responses. We also detected memory T cells specific for one or more of these peptides in patients with breast cancer and squamous cell carcinomas of the head and neck (SCCHN). T cells from one patient, restimulated once in vitro, could kill the tumor cell line from which the peptides were derived. Immunohistochemical analysis of tumor lines and tissue sections showed cyclin B1 overexpression and aberrant localization in the cytoplasm instead of the nucleus. Sequencing genomic DNA and cDNA corresponding to P1-P6 region showed that differences in COOH-terminal residues were not due to either DNA mutations or errors in transcription, suggesting a high error rate in translation of cyclin B1 protein in tumors.
TGIF Governs a Feed-Forward Network that Empowers Wnt Signaling to Drive Mammary Tumorigenesis
Authors: Ming-Zhu Zhang, Olivier Ferrigno, Zhe Wang, Mutsuko Ohnishi, Céline Prunier, Laurence Levy, Mohammed Razzaque, Williams C Horne, Damian Romero, Guri Tzivion, Frédéric Colland, Roland Baron, Azeddine Atfi
Journal: Cancer Cell (2015)
Conscientious objection in medicine: Author did not meet standards of argument based ethics
Authors: Frank A Chervenak, Laurence B McCullough
Journal: BMJ (2006)

EDITOR—Savulescu's account of conscientious objection in medicine is a bold statement that requires all obstetricians to perform abortions, regardless of any moral convictions that they may have to the contrary.1 Unfortunately, he violates the standards of argument based ethics.2 3

He claims that professional commitments, what should be provided to patients, are based on law and the just management of …
The global cigarette
Authors: N. Gray
Journal: BMJ (1996)

The time is ripe for a serious attempt to reduce the tar and nicotine content of cigarettes worldwide. Progress against tobacco associated disease, described in the BMJ as early as 19501 and decisively quantified in 1994,2 has been painfully slow. As smoking increases in less developed countries the global burden of avoidable disease will soar.3 There are no satisfactory excuses for ignoring any available measures which can minimise this.

At an individual level, the dose of carcinogen reaching the lung is determined by the number of cigarettes smoked over time, the tar content of the cigarette, the degree of inhalation (which may well depend on the nicotine content), and the size of the butt which is left. At a global level, mortality from lung cancer is determined by the same parameters and by the number of smokers in the world.

Since the 1980s it has been accepted that reducing …
The Nostrum and Other Evils.
Authors: T. B. Moore
Journal: JAMA (1906)

Canon City, Colo., March 28, 1906. <h3>To the Editor:</h3> —In all that has been said about the nostrum and proprietary-medicine question, it seems to me that the real remedy has not been emphasized as it should be. If every physician would get right and keep right, these evils would soon cease to exist; and no one need to go to extremes in the matter, either. There are comparatively few "ethicals," and it is easy to select them. Those made by reputable manufacturing houses and whose ingredients are well known, and for which no extravagant claims are made, should be the only ones prescribed. We all condemn "counter prescribing" and yet keep on prescribing proprietaries and help the druggist to do a wholesale business in that line. Why not stop it, and stop it right now? Another thing: How long are we going to subscribe for, contribute to and read medical
A NOVEL TECHNIQUE TO IDENTIFY TRANSPORT TEMPLATES IN THE HUMAN LEFT VENTRICLE USING DOPPLER ECHOCARDIOGRAPHY AND COMPUTATIONAL MODELING
Authors: Shawn C. Shadden, Sahar Hendabadi, Yolanda Benito, Raquel Yotti, Javier Bermejo, Juan Carlos del Alamo
Journal: Journal of the American College of Cardiology (2013)
Physician Utilization Disparities Between the Uninsured and Insured
Authors: Chris Hafner-Eaton
Journal: JAMA (1993)

This study examines the associations between lack of health insurance coverage and physician utilization for the chronically ill, acutely ill, and well nonelderly populations in the United States.Cross-sectional data from the 1989 National Health Interview Survey, conducted by the National Center for Health Statistics, were analyzed for the nonelderly population using a correlational, two-group design (N = 102,055). Analytic models, using multiple logistic regression, were tested to predict the odds and likelihood of physician utilization for the uninsured and insured in the three subpopulations (ie, chronically ill, acutely ill, and well), controlling for health status, number of conditions, and geographic, sociodemographic, and economic factors. Disparities in utilization were then calculated between the uninsured and insured for each subpopulation.The nonelderly uninsured were consistently less likely than the insured to have received any health care within 12 months. Moreover, there were differential effects of being uninsured on utilization depending on whether an individual was chronically ill, acutely ill, or well. Whereas chronically ill and well uninsured persons were half as likely to have seen a physician as their insured counterparts (odds ratio, 0.50), acutely ill uninsured persons were almost two thirds as likely to receive physician care (odds ratio, 0.62). Thus, the disparity in physician utilization between the uninsured and insured was larger for the chronically ill and well than for the acutely ill; uninsured acutely ill were less likely to go without care. Of the three populations, those in the well population had average disparities with the largest magnitude (40%), compared with disparities of the chronically ill (20%) and acutely ill (10%).These disparities represent large inequities in utilization of care by the uninsured, particularly for the chronically ill and well. Whether these disparities result from lower access or individual choice cannot be determined from this study. When viewed in light of other studies examining the impact of utilization on health status, these results provide support for the development of comprehensive health insurance packages with universal coverage and better inclusion of chronic and preventive care models in benefit packages.
Controlling the Metabolic Roller Coaster in Diabetes
Authors: Anne R. Cappola, Edward H. Livingston
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Tissue need" and limb collateral arterial growth. Skeletal contractile power and perfusion during collateral development in the rat.
Authors: A J Paskins-Hurlburt, N K Hollenberg
Journal: Circulation Research (1992)

Among the factors that might influence collateral arterial growth after arterial occlusion, the capacity to deliver blood flow in relation to metabolic need and work performance are obvious candidates. In this study in rats after superficial femoral artery ligation, we assessed collateral arterial growth (by arteriography), basal and peak limb blood flow during acetylcholine-induced vasodilation (by electronic drop counting), pressure-flow relations, and contractile power of the gastrocnemius muscle (force transduction during sciatic nerve stimulation) at intervals over 3 months after superficial femoral artery ligation. Basal and peak blood flow and muscle contractile power were clearly reduced 1 week after ligation but had returned to normal by 3 weeks. Major collateral arterial growth, however, progressed between 3 weeks and 3 months. The limb perfusion pressure-blood flow relation was still altered at 3 weeks, with blunting of the normal autoregulation, and became more normal by 3 months after superficial femoral artery ligation. Collateral arterial growth continues after blood flow adequate to maintain work performance has been restored and may reflect a response to more subtle abnormalities involving distal pressure delivery, evident in altered pressure-flow relations.
BERYLLIUM POISONING REGISTRY
Authors: Harriet L. Hardy
Journal: JAMA (1953)

To the Editor:—  A man-made illness of considerable interest has been reported in the medical literature in this country since 1943 under various titles, in general referring to its association with exposure to certain beryllium compounds. As the years go by, more cases appear from a variety of industrial and research operations using beryllium compounds. With funds supplied by the Atomic Energy Commission, it is planned to develop a beryllium case registry at the Massachusetts General Hospital. The purpose of the registry is to facilitate a study of the epidemiology of this disease, an evaluation of the beryllium hazard of incriminated operations, and dissemination of knowledge of the clinical course of beryllium poisoning, especially in relationship to its medical management. The material collected is to be available for study, and from time to time data will be sent to participating physicians summarizing facts that have been established.  This description is
RESIDUAL INFECTION OF THE JAWS
Authors: R. S. Taylor
Journal: BMJ (1934)

LM,EDICAL JOUJRN4AL2. The method has been put to a very severe test, inasmuch as all cases that were not suitable, or were in too bad a condition, for suprapubic prostatectomy were, provided they were not moribund, treated by it.3. The immediate and remote complications and results are described.4. Normal relief was obtained in 50 per cent. of the cases, and this standard of relief has been maintained for over five years.By using a little discrimination in the selection of cases, and with increasing experience, the proportion of cases enjoying normal relief would probably exceed 80 per cent.5. The death rate directly attributable to operation by this technique is very low, even when the worst possible risks are dealt with.By eliminating the very bad risks it can probably be reduced to less than 1 per cent.
Sinus arrest during treatment with amiodarone.
Authors: W N Brodine, J DeSantis
Journal: BMJ (1982)

pressures than those studied in the non-drug studies.The blood pressures before treatment of patients in the drug and non-drug studies were not significantly different (systolic blood pressure, t=0 69, df 98; diastolic blood pressure, t=0 43, df 109).In conclusion, we suggest that rather than see the outcome of our analysis primarily in terms of non-pharmacological treatments being shown to be less effective than drug treatments, the most important outcome is that several non-drug treatment modalities can be seen to have produced substantial and lasting reduction in blood pressure.These benefits are perhaps overall not as great as those of the drug studies, but are significantly greater than those of the placebo studies and are of appreciable clinical importance.We would certainly agree that many mildly hypertensive patients might be treated effec- tively by non-drug techniques, and indeed have concluded that: "Weight loss, progressive muscle relaxation, and yoga could provide competitive alternatives to step 1 drug treat- ment," and should be considered by the doctor.