tbuckley/cabot-search huggingface dataset:
The Doctor is sick
Authors: F. J Bowden
Journal: BMJ (2009)

In his opening lecture to first year medical students, one of my friends shows an excerpt from the 1991 film The Doctor, which is based on the real life experience of an American surgeon. The film stars William Hurt who, when we first meet him, displays the stereotypical features of the macho surgeon—clinical acumen coated in arrogant self assuredness. He is a doctor who focuses on the disease in the person, rather than the person in the disease. When he is himself diagnosed with throat cancer we watch his journey from detached technician to vulnerable patient and, finally, to rejuvenated human being. The students enjoy the clip and usually offer undertakings never to behave like the unreconstructed Hurt. But as any wise teacher knows, instructional inputs do not automatically translate into learning.

The “doctor-as-patient” piece is an occasional offering in medical literature and popular among the profession. One premise of these stories is that doctors have a unique insight into the medical system and are able to describe their symptoms with more clarity …
Artesunate-clindamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products
Authors: Orazio Luca Strusi, Pedro Barata, Daniela Traini, Paul M. Young, Salvatore Mercuri, Gaia Colombo, Fabio Sonvico, Ruggero Bettini, Paolo Colombo
Journal: Journal of Controlled Release (2010)
The Flicker Fusion Frequency and Its Response to Nitroglycerin in Normal Subjects and in Patients with Cardiovascular Disease
Authors: ANCEL KEYS, ERNST SIMONSON
Journal: Circulation (1952)

Krasno and Ivy have claimed that the change after sublingual nitroglycerin in the frequency at which a flickering light appears to fuse (f.f.f.) sharply differentiates between cardiovascular normals and patients with coronary and/or hypertensive disease and that this test may be useful in detecting and evaluating such disease. On the basis of a detailed analysis of the original publication and of data on 304 men these claims are denied. Indications for further study of flicker phenomena are discussed and fiducial norms are presented.
Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1–related food allergens
Authors: Beatrice Jahn-Schmid, Astrid Radakovics, Dirk Lüttkopf, Stephan Scheurer, Stefan Vieths, Christof Ebner, Barbara Bohle
Journal: Journal of Allergy and Clinical Immunology (2005)
Melittin-grafted HPMA-oligolysine based copolymers for gene delivery
Authors: Joan G. Schellinger, Joshuel A. Pahang, Russell N. Johnson, David S.H. Chu, Drew L. Sellers, Don O. Maris, Anthony J. Convertine, Patrick S. Stayton, Philip J. Horner, Suzie H. Pun
Journal: Biomaterials (2012)
An Address ON THE CLINICAL MEASUREMENT OF DIASTOLIC BLOOD PRESSURE AND CARDIAC STRENGTH: Opening Address of the Winter Session at the North-East London Post-Graduate College, October 27th, 1910
Authors: L. Brunton
Journal: BMJ (1910)

AND GENTLBMRN,-I thank you for the honour you have done me in asking me to address you to-night, and also for the choice of subject which you have given me.I am informed that you would like me to speak on the clinical aspects of bloodw pressure, a subject in which I am particularly interested.It is said, and I believe with truth, thatwhen a man grows old he reverts to the subjects of which he was fond in his youth, and on the 25th of next month it will be exactly forty-five years since I made my first experiment on blood pressure under the guidance of my friend, the late Professor Arthur Gamgee.At that time instruments for recording blood pressure were very few in number altogether, and there was not such a thing in the three kingdoms.The apparatus that I used was not a recording one, and was of the very simplest kind.It was a crude imitation of Marey's haemodynamometer, and consisted of a pomatum bottle, half filled with mercury, and with three holes bored through the cork.In the first of those was fixed an upright tube, about 8in.long, in which the mercury oscillated freely, and gave the maximum and minimum pressures.The second was similar in size, but had a constriction at one part, so that the mercury oscillated very little in it, and thus the mean pressure was indicated.The third tube was bent, and communicated with the artery.The instrument was very crude, but was neverthe-
Pediatric Infectious Diseases: Principles and Practice
Authors: Leslie L. Barton
Journal: JAMA (1996)

Jenson and Baltimore's<i>Pediatric Infectious Diseases: Principles and Practice</i>is an important addition to the burgeoning library of pediatric infectious disease books. It is also a volume refreshing both in its format and in its attempt to fight "the problem of bloated books—bibliobesity" (<i>New York Times</i>, July 30, 1995). Written for primary care practitioners as well as for infectious disease specialists, the book has a syndrome-oriented approach. Each chapter is clearly and concisely written and extremely well organized. Discussions logically flow from disease definition to epidemiology, pathogenesis, clinical signs and symptoms, diagnosis, treatment, prognosis, and prevention. The references are up-to-date and adequate and contain both reviews and key articles. There are general topic sections—including microbial pathogenesis, diagnostic methods, disease prophylaxis, and treatment—and system-oriented ones—including respiratory, cardiovascular, and gastrointestinal infections and infections in the neonate and immunocompromised host. This volume is meant to be comprehensive without being encyclopedic. Despite 64
Effect of large doses of etretinate (TigasonR) on enzymes of the rat kidney
Authors: S. GUTSCHMIDT, D. TSAMBAOS
Journal: British Journal of Dermatology (1982)

Journal Article Effect of large doses of etretinate (Tigason®) on enzymes of the rat kidney Get access S. GUTSCHMIDT, S. GUTSCHMIDT Department of Gastroenterology and Internal Medicine Search for other works by this author on: Oxford Academic Google Scholar D. TSAMBAOS D. TSAMBAOS Department of Dermatology, University Medical Centre Steglitz, The Free University Berlin, Hindenburgdamm 30,1000 Berlin 45, West Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 2, 1 August 1982, Pages 251–252, https://doi.org/10.1111/j.1365-2133.1982.tb00350.x Published: 01 August 1982
Points from Letters: Mental Retardation
Authors: G. Dutton
Journal: BMJ (1964)

Third Stage of Labour SIR,-Placental separation is a leisurely process and I cannot agree that it is usually complete very soon after the birth of the baby.Mr. D. G. Bonham (28 December, p. 1620) recommends that no woman should be allowed a normal third stage but that ergometrine should always be given with the crowning of the head.The spasm thus induced interferes with the normal mechanism of separation and predisposes to retention of the placenta.He would have us counter these evils by early cord traction.Thus he claims a reduction in the primary post-partum haemorrhage (P.P.H.) rate at a cost only of a rather smaller rise in the manual removal rate.So Homo sapiens knows best.Mother Nature should take a refresher course at U.C.H.Primary P.P.H. is defined as a loss of 568 ml. of " blood " during the first 24 hours.Any pupil midwife knows that the measured loss includes widely varying and often sub-
Epidemiologic approaches to persons with exposures to waste chemicals.
Authors: P J Landrigan
Journal: Environmental Health Perspectives (1983)

Evaluation of disease in populations exposed to hazardous waste dumps requires: documentation of the chemicals in a dump; assessment of the materials released from the dump into environmental media; tracing of the probable routes of human exposure (groundwater, air, direct contact, or occupational); development, when possible, of individual exposure estimates and/or direct biological assessment of absorption; precise definition of the subpopulations at highest risk of exposure; and the employment of specific and sensitive health outcome indicators. Demonstration of dose-response relationships between chemical exposure and disease provides the most compelling evidence for a chemical etiology of illness in exposed populations. Interpretation of apparently negative data must be cautious, given the small size of most high-risk populations and the usual brevity of exposures.
SAWDUST BEDS FOR THE HELPLESS UNTIDY INSANE
Authors: William R. Thompson
Journal: JAMA (1927)

Dr. F. G. LaRue, superintendent for the Eastern State Hospital at Lexington, Ky., noticed in the quarterly report for July of the Department of Public Welfare of Illinois a short description of sawdust beds, in use in a hospital in Bauch, Germany, for the helpless, untidy insane. This class of patients is the most troublesome of all in any hospital, and any provision that adds to their comfort and makes their care easier is worth installing.  He at once had them installed in the Eastern State Hospital for this class of patients, and the results have been so satisfactory after more than a year's trial that I feel that all hospitals should know of them. So far as I know, this is the only hospital in this country using them.  At present, there are thirty-four of these beds in use, and every one in charge, including the attendants, is highly
IN VIVO DETOXIFICATION OF ENDOTOXIN BY THE RETICULOENDOTHELIAL SYSTEM
Authors: T. Wiznitzer, N. Better, W. Rachlin, N. Atkins, E. D. Frank, J. Fine
Journal: The Journal of Experimental Medicine (1960)

Evidence is presented that The normal RES extracts endotoxin from the circulation and inactivates it very rapidly. When the RES has been damaged, whether by a blockading agent, such as thorotrast, or by a reversible degree of hemorrhagic shock, it cannot extract more than a small per cent of the amount of the endotoxin the normal system can extract. Of that fraction of endotoxin which is extracted, very little is detoxified. An organ like the kidney, which does not contain a significant amount of RE tissue, does not extract more than an insignificant percentage of the injected amount, and therefore does not detoxify endotoxin. Since dephosphorylation is a process concurrent with detoxification, and does not occur in an organ which does not extract or inactivate a significant amount of injected endotoxin, it is probable that this process is an indirect index of detoxification. Within the time limits of these experiments, plasma alone does not inactivate endotoxin.
Intrapleural Tetracycline for Recurrent Pneumothorax
Authors: John R. Corboy
Journal: JAMA (1991)

<h3>To the Editor.—</h3> The recent study by Light et al<sup>1</sup>on the use of intrapleural tetracycline to prevent recurrent spontaneous pneumothorax is an excellent example of a statistically significant improvement in outcome associated with an overall persistently poor outcome. Although it was true that 41% of untreated patients had recurrence, so did an astounding 25% of men treated with a drug that caused severe chest pain in over half. Even patients with primary pneumothorax (who presumably were younger and healthier) had a 10.5% recurrence rate with treatment. Thoracotomy with pleural abrasion is associated with a low risk of serious complications, with the risk greatest in elderly patients with chronic obstructive pulmonary disease, but typically carries a recurrence rate of less than 1%.<sup>2</sup>Thus, a blanket recommendation to attempt intrapleural installation of tetracycline to prevent recurrent spontaneous pneumothorax is unjustified. Given that treatment with intrapleural tetracycline still results in
Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen
Authors: Lesley-Ann Sutton, Efterpi Kostareli, Anastasia Hadzidimitriou, Nikos Darzentas, Athanasios Tsaftaris, Achilles Anagnostopoulos, Richard Rosenquist, Kostas Stamatopoulos
Journal: Blood (2009)
Racial differences in cardiac structure and function in essential hypertension
Authors: J Mayet, M Shahi, R A Foale, N R Poulter, P S Sever, S A M Thom
Journal: BMJ (1994)

To assess racial differences in cardiac structure and function in patients presenting with previously untreated hypertension.Untreated black patients with hypertension were compared with untreated white patients matched for age and sex. Both groups had similar body mass indices, blood pressures, and reported duration of hypertension.Cardiovascular risk factor clinic for outpatients.36 men and 22 women with untreated essential hypertension.Variables of heart structure and function on cross sectional and Doppler echocardiography.The black patients had a significantly greater interventricular septal thickness (mean 1.23 (95% confidence interval 1.14 to 1.33) v 1.09 (1.02 to 1.16) cm; P = 0.02) and posterior wall thickness (mean 1.14 (1.07 to 1.22) v 0.96 (0.88 to 1.03) cm; P = 0.001) than the white patients, although left ventricular internal diameter was not significantly different (mean 4.90 (4.68 to 5.12) v 4.82 (4.64 to 5.01) cm; P = 0.59). This resulted in a significantly greater left ventricular mass index (mean 151 (137 to 164) v 120 (107 to 133) g/m2; P = 0.001) and relative wall thickness (mean 0.47 (0.43 to 0.51) v 0.40 (0.37 to 0.42) cm; P = 0.004) in the black patients. Comparison of Doppler measures of left ventricular diastolic function showed a significantly longer isovolumic relaxation time in black patients (mean 107 (98 to 116) v 92 (83 to 101) ms; P = 0.02) compared with white patients, although peak early to atrial filling ratios were similar in both groups (mean 1.14 (0.95 to 1.32) v 1.04 (0.94 to 1.15); P = 0.37).Among previously untreated hypertensive patients, black subjects compared with white subjects have significantly higher left ventricular mass index and relative wall thickness, as well as more impairment of left ventricular function during diastole.
Research is no longer attractive
Authors: R. I G Holt
Journal: BMJ (2008)

<h3>Abstract</h3> BAP1 is a ubiquitin hydrolase whose deubiquitinase activity is mediated by polycomb group-like protein ASXL2. Cancer-related mutations/deletions of <i>BAP1</i> lead to loss-of-function either by directly targeting the catalytic (UCH) or ULD domains of BAP1, the latter disrupts binding to ASXL2, an obligate partner for BAP1 enzymatic activity. However, the biochemical and biophysical properties of the domains involved in forming the enzymatically active complex are unknown. Here we investigate the molecular dynamics, kinetics and stoichiometry of these interactions. We demonstrate that the BAP1 and ASXL2 domain/proteins or protein complexes produced in either bacteria or baculovirus are structurally and functionally active. The interaction between BAP1 and ASXL2 is direct, specific, and stable to <i>in vitro</i> biochemical and biophysical manipulations as detected by isothermal titration calorimetry, GST association, and optical biosensor assays. Association of the ASXL2-AB box greatly stimulates BAP1 deubiquitinase activity. A stable ternary complex can be formed comprised of the BAP1-UCH, BAP1-ULD, and ASXL2-AB domains. Binding of the BAP1-ULD domain to the ASXL2-AB box is rapid, with fast association and slow dissociation rates. Stoichiometric analysis revealed that one molecule of the ULD domain directly interacts with one molecule of the AB Box. Real-time kinetics analysis of ULD/AB protein complex to the UCH domain of BAP1, based on SPR, indicated that formation of the ULD/AB complex with the UCH domain is a single-step event with fast association and slow dissociation rates. These structural and dynamic parameters implicate the possibility for future small-molecule approaches to reactivate latent wild-type UCH activity in BAP-mutant malignancies.
Human endurance--mind or muscle?
Authors: D. E. Taylor
Journal: British Journal of Sports Medicine (1978)

Two investigations have been carried out. The first studied the effects of autonomic blockade on the cardiovascular response to a step test, a 50% maximum isometric grip test and a Valsalva manoeuvre: the step test was of 5 minutes duration and the other two for as long as possible. beta adrenergic blockade by propanolol diminished the blood pressure and pulse rate response to both the step test and isometric grip. The pulse rate response to the step test was also affected by cholinergic blockade with atropine. The response to the Valsalva test showed a cholinergic blockade effect of pulse rate alone and a blood pressure response alone on alpha adrenergic blockade by phenoxybenzamine. The second studied psychological stressing on physical and mental ability. A potential 'punishment' situation increased the blood pressure and pulse rate response to isometric grip while decreasing the time for which it could be maintained. A potential 'reward' situation increased both the maximum grip and the time for which 50% grip could be maintained. It is concluded that psychological factors can affect performance dependant on whether the situation is perceived as one of 'reward' or 'punishment'. A factor in the mediation of the adverse response is an inappropriate response of the autonomic nervous system.
718. PTD-Fusion Peptide as a Delivery Vehicle for siRNA To Target HIV Reservoirs
Authors: Ashok Chauhan, Avindra Nath, Daivd Levy, Suzanne Gartner
Journal: Molecular Therapy (2006)

Viral reservoirs are established early during an HIV infection; remain unaffected by highly active antiretroviral therapy (HAART) for their whole life and virus reemerge after treatment failure or interruption in treatment. It is often proposed that the brain serves as an important HIV reservoir. While macrophages/microglia (MM) in the brain undergoes a productive infection following virus entry, HIV infection in astrocytes becomes dormant after a brief period of viral replication. Given their lifespan and low rate of turnover, astrocytes may harbor the viral genome for long periods of time. In the presence of HAART, viral transcription and translation proceeds normally in the infected cells, except that virus is not assembled into fully infectious particles. Moreover, HIV infected macrophages sustain viral replication for their whole life and may be responsible for rebound of the virus in antiviral treatment interruption or failures. To reduce the impact of viral proteins, viral replication and emergence of drug resistance, inhibition of HIV transcription is of the utmost importance. To inhibit HIV transcription and replication we used Tat siRNA to target HIV in latently infected monocytic, HIV infected primary macrophages and astrocytic (SVGA) LTR-GFP reporter cells. We used a peptide based approach to deliver siRNA. Peptide based transduction of siRNA was very efficient in macrophages and astrocytes without any toxicity as compared to Lipofectamine 2000 and PEI transfection reagents. Tat siRNA strongly inhibited Tat mediated LTR transactivation activity up to 120 hrs in SVGA- LTR-GFP reporter cells in a dose dependent manner (0.4 μM–0.1 μM). Further, Tat siRNA strongly inhibited TNF-α reactivated HIV in latently HIV infected monocytic cells (THP89) for 72 hrs. To verify further whether Tat siRNA can inhibit HIV infection in primary macrophages, therefore, we established HIV infection in macrophages and then Tat siRNA was transduced on 2nd day post infection. In different experiments, we observed strong inhibition of HIV replication from day 12 to day 21 post infection in macrophages using Tat-siRNA. Conclusion: HIV transcription and replication is strongly inhibited by Tat-siRNA in cells which acts as a long term reservoir of HIV in the human body.
ABC of colorectal diseases. Tropical colonic diseases.
Authors: B. K. Mandal, P. F. Schofield
Journal: BMJ (1992)

J in tropicalIn this age of increasing foreign travel it is quite possible for a patient presenting with diarrhoea to be suffering from a tropically acquired chia coli infection.Unless an accurate travel history is taken the diagnosis may be delayed with a resultant increase in morbidity caused by inappropriate treatment.
Extensive fixed drug eruption due to the Japanese herbal drug 'kakkon-to'
Authors: N. Fujimoto, S. Tajima
Journal: British Journal of Dermatology (2003)

Journal Article Extensive fixed drug eruption due to the Japanese herbal drug ‘kakkon‐to’ Get access N. Fujimoto, N. Fujimoto Department of Dermatology, National Defence Medical College, 3–2 Namiki, Tokorozawa, Saitama 359–8513, Japan E‐mail: nfujimo@me.ndmc.ac.jp Search for other works by this author on: Oxford Academic Google Scholar S. Tajima S. Tajima Department of Dermatology, National Defence Medical College, 3–2 Namiki, Tokorozawa, Saitama 359–8513, Japan E‐mail: nfujimo@me.ndmc.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 6, 1 December 2003, Pages 1303–1305, https://doi.org/10.1111/j.1365-2133.2003.05676.x Published: 01 December 2003
COMPLETE VERSUS CULPRIT LESION REVASCULARIZATION DURING PRIMARY PERCUTANEOUS INTERVENTION (PCI) WITH ST-ELEVATION MYOCARDIAL INFARCTION (STEMI): A COMPREHENSIVE META-ANALYSIS OF RANDOMIZED CONTROL TRIALS
Authors: Navkaranbir S. Bajaj, Himanshu Aggarwal, Saurabh Gaba, Pankaj Arora, Vikas Bhatia, Ankit Mehra, Gopal Ghimire, Brigitta Brott
Journal: Journal of the American College of Cardiology (2015)
Metabolic Syndrome in Adolescence
Authors: Stamatis P. Efstathiou, Irini I. Skeva, Evi Zorbala, Evangelos Georgiou, Theodore D. Mountokalakis
Journal: Circulation (2012)

There are well-established predisposing factors for the development of metabolic syndrome (MetS) in childhood or adolescence, but no specific risk profile has been identified as yet. The Prediction of Metabolic Syndrome in Adolescence (PREMA) study was conducted (1) to construct a classification score that could detect children at high risk for MetS in adolescence and (2) to test its predictive accuracy.In the derivation cohort (1270 children), data from natal and parental profile and from initial laboratory assessment at 6 to 8 years of age were used to detect independent predictors of MetS at 13 to 15 years of age according to the International Diabetes Federation definition. In the validation cohort (1091 adolescents), the discriminatory capacity of the derived prediction score was tested on an independent adolescent population. MetS was diagnosed in 105 adolescents in the derivation phase (8%), whereas birth weight <10th percentile (odds ratio, 6.02; 95% confidence interval, 2.53-10.12, P<0.001), birth head circumference <10th percentile (odds ratio, 4.15; 95% confidence interval, 2.04-7.14, P<0.001), and parental overweight or obesity (in at least 1 parent; odds ratio, 3.22; 95% confidence interval, 1.30-5.29, P<0.01) were independently associated with diagnosis of MetS in adolescence. Among adolescents in the validation cohort (86 [8%] with MetS), the presence of all these 3 predictors predicted MetS with a sensitivity of 91% and a specificity of 98%.The coexistence of low birth weight, small head circumference, and parental history of overweight or obesity may be useful for detection of children at risk of developing MetS in adolescence.