tbuckley/cabot-search huggingface dataset:
Malignant proliferating trichilemmal tumour and CAV (cisplatin, adriamycin, vindesine) treatment
Authors: I. Hayashi, T. Harada, M. Muraoka, M. Ishii
Journal: British Journal of Dermatology (2004)

Journal Article Malignant proliferating trichilemmal tumour and CAV (cisplatin, adriamycin, vindesine) treatment Get access I. Hayashi, I. Hayashi Department of Plastic and Reconstructive Surgery, Osaka City University Graduate School of Medicine, Asahi 1‐4‐3, Abeno, Osaka 545‐8585, Japan E‐mail: izumineko@med.osaka‐cu.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Harada, T. Harada Department of Plastic and Reconstructive Surgery, Osaka City University Graduate School of Medicine, Asahi 1‐4‐3, Abeno, Osaka 545‐8585, Japan E‐mail: izumineko@med.osaka‐cu.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Muraoka, M. Muraoka Department of Plastic and Reconstructive Surgery, Osaka City University Graduate School of Medicine, Asahi 1‐4‐3, Abeno, Osaka 545‐8585, Japan E‐mail: izumineko@med.osaka‐cu.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Ishii M. Ishii Department of Plastic and Reconstructive Surgery, Osaka City University Graduate School of Medicine, Asahi 1‐4‐3, Abeno, Osaka 545‐8585, Japan E‐mail: izumineko@med.osaka‐cu.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 1, 1 January 2004, Pages 156–157, https://doi.org/10.1111/j.1365-2133.2004.05670.x Published: 01 January 2004
The right to food security
Authors: V. Shatrugna, R. Srivatsan
Journal: BMJ (2012)

Communities must push back against global policy decisions that fuel Third World hunger 

The report from the Right to Food and Nutrition Watch published during October 2012 considered the effects of globalised food policies on populations in the Third World.1 It offered a very different perspective on food insecurity than that provided by official United Nations/World Bank documents. The authors of the report considered food security in light of social determinants of nutrition, such as food availability, agricultural policy, land transactions, cropping patterns, and agricultural finance. The report focused on the lack of accountability of large food producers that also own vast tracts of land to the people who face hunger and who have a right to food. Their damning indictment is that “the right to food of people around the planet has primacy over the need to fuel cars and economies in the European Union or North America.”

The report included a review of the progress of the Committee on World Food Security (an international body set up by the UN) after it was reformed in 2009 to include people’s organisations. The report stressed the importance of keeping the right to food as a benchmark in policy decisions. The World Trade Organization routinely …
A case of optic atrophy possibly induced by quinoline in acrodermatitis enteropathica
Authors: ANTONIO GARCIA-PEREZ, CARMEN CASTRO, ANTONIO FRANCO, RICARDO ESCRIBANO
Journal: British Journal of Dermatology (2006)

A 2‐year‐old girl with acrodermatitis enteropathica, developed optic atrophy during quinoline treatment (600 mg/day, later gradually increased to 1700 mg/day; a total dose of 280 g was given). The optic atrophy developed rapidly 9 months after the start of the quinoline treatment. The right eye was blinded and developed a convergent strabismus. Eight months after the quinoline had been stopped, the left eye began a slow and partial recovery of vision with an improvement in the appearance of the optic disc.
Fairbank's Atlas of General Affections of the Skeleton
Authors: Reginald R. Cooper
Journal: JAMA (1977)

Soon after its publication 25 years ago, the first edition of this text rapidly gained a worldwide reputation as the standard repository of weird and wonderful skeletal growth and developmental disorders. The physician who encountered a patient with one of these uncommon disturbances optimistically reached for Fairbank's Atlas , knowing that he would likely find a case report to help him make the diagnosis. Those accustomed to this habit will warmly welcome the updated second edition.  T. J. Fairbank could not have chosen a more qualified person to be his co-writer than Ruth Wynne-Davies. Her interest in skeletal dysplasias and genetics superbly qualifies her to revise portions of the book that had become dated in the light of recent advancements.  The authors have made some rather substantial changes in this edition, yet they preserve much of the valuable format of the first edition. They wisely included descriptions of newly described dysplasias
Stem cells in human neurodegenerative disorders — time for clinical translation?
Authors: Olle Lindvall, Zaal Kokaia
Journal: Journal of Clinical Investigation (2010)

Stem cell–based approaches have received much hype as potential treatments for neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in animal models of neurodegenerative diseases can improve function by replacing the lost neurons and glial cells and by mediating remyelination, trophic actions, and modulation of inflammation. Endogenous neural stem cells are also potential therapeutic targets because they produce neurons and glial cells in response to injury and could be affected by the degenerative process. As we discuss here, however, significant hurdles remain before these findings can be responsibly translated to novel therapies. In particular, we need to better understand the mechanisms of action of stem cells after transplantation and learn how to control stem cell proliferation, survival, migration, and differentiation in the pathological environment.
The Evolution of Preventive Medicine in the United States Army, 1607-1939
Authors: Paul E. Steiner
Journal: JAMA (1969)

This unofficial history describes the origins and development of principles and practices designed to prevent disease and preserve the life of soldiers. It correlates the military discoveries and advances with the knowledge derived from public health and preventive medicine. The army had a big stake in preventive medicine. Many of its essential operations were formerly attended with great risk. Universities assembled 10,000 youths in dormitories every fall, usually with impunity; armies collected similar numbers of the same age in barracks or in camp, and epidemics promptly followed. The differences concerned factors in preventive medicine and epidemiology, which were discovered only gradually. The author shows that army medicine contributed richly to the solution of these and other problems. Source material is scanty prior to the Revolution but increases greatly with time and wars. The progress, slow for over two centuries, exploded with the microbiological era. A number of old administrative orders,
95 HEPATOCYTES SPECIFIC DELETION OF C-MET LEADS TO THE DEVELOPMENT OF SEVERE NON-ALCOHOLIC-STEATOHEPATITIS (NASH) IN A MURINE NASH MODEL
Authors: F. Schumacher, D.C. Kroy, M. Hatting, N. Gassler, M.V. Boekschoten, M. Muller, K.L. Streetz, C. Trautwein
Journal: Journal of Hepatology (2012)
Maternal Alcohol Consumption and Birth Weight
Authors: James L. Mills
Journal: JAMA (1984)

The relationship between maternal alcohol drinking during pregnancy and birth weight was examined using prospectively collected data from 31,604 pregnancies. The percentage of newborns below the tenth percentile of weight for gestational age increased sharply with increasing alcohol intake. After adjustment for other risks, a reduction in mean birth weight was seen in drinkers compared with nondrinkers, ranging from 14 g in those drinking less than one drink each day to 165 g in those drinking three to five drinks each day. The adjusted odds ratio for producing a small-for-dates newborn compared with nondrinkers ranged from 1.11 in those drinking less than one drink daily to 1.96 in those drinking three to five drinks daily. Consuming at least one to two drinks daily was associated with a substantially increased risk of producing a growth-retarded infant. Conversely, consuming less than one drink daily had a minimal effect on intrauterine growth and birth weight.
Response to Activated Protein C and Cerebrovascular Disease
Authors: Johanna G. van der Bom
Journal: Annals of Internal Medicine (1997)

Letters15 May 1997Response to Activated Protein C and Cerebrovascular DiseaseJohanna G. van der Bom, MD, Michiel L. Bots, MD, PhD, and Cornelis Kluft, PhDJohanna G. van der Bom, MDErasmus University Medical School, Rotterdam, the NetherlandsTNO Prevention and Health, Leiden, the NetherlandsSearch for more papers by this author, Michiel L. Bots, MD, PhDErasmus University Medical School, Rotterdam, the NetherlandsTNO Prevention and Health, Leiden, the NetherlandsSearch for more papers by this author, and Cornelis Kluft, PhDErasmus University Medical School, Rotterdam, the NetherlandsTNO Prevention and Health, Leiden, the NetherlandsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-10-199705150-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Jones and Alving's comments offer us the opportunity to further emphasize the difference between the APC response test and DNA analysis for factor V Leiden mutation. We agree that diagnosis of factor V Leiden mutation by DNA assay is the gold standard and that initial screening for factor V Leiden mutation is best performed by the APC response test with addition of factor V-deficient plasma. We would, however, like to emphasize that factor V Leiden mutation is but one determinant of the response to APC. Ranges of the response to APC are broad, indicating that other factors determine ...REFERENCE1. Rosen S, Johansson K, Lindberg K, Dahlback B. Multicenter evaluation of a kit for activated protein C resistance on various coagulation instruments using plasmas from healthy individuals. Thromb Haemost. 1994; 72:255-60. Google Scholar Author, Article, and Disclosure InformationAuthors: Johanna G. van der Bom, MD; Michiel L. Bots, MD, PhD; Cornelis Kluft, PhDAffiliations: Erasmus University Medical School, Rotterdam, the NetherlandsTNO Prevention and Health, Leiden, the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1997Volume 126, Issue 10Page: 833KeywordsAtrial premature contractionBlood plasmaCerebrovascular diseasesCholesterolDNAFactor analysisFactor V LeidenReproducibility ePublished: 15 August 2000 Issue Published: 15 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evolutionary neuroscience: Limitations and prospects
Authors: Georg F. Striedter
Journal: Behavioral and Brain Sciences (2006)

Overall, most of the reviewers agree that Principles of Brain Evolution was a welcome addition to the field, and kindly describe it as carefully researched and lucidly written. Thereafter, they note some gaps – principally, adaptive scenarios, microevolutionary studies, and computational models. I here admit to those deficiencies but explain why they exist and how they might be filled. In addition, one commentator criticizes my analysis of hominin brain evolution, and another finds my principle of “large equals well-connected” to be inconsistent with the data. I rebut those two critiques. Hopefully, this process of critique and counterpoint will stimulate some readers to pursue the mentioned thoughts and to engage in new research.
Transcriptional regulation of autophagy in RAS-driven cancers
Authors: Ravi K. Amaravadi
Journal: Journal of Clinical Investigation (2015)

RAS-driven cancers exhibit variable dependency on autophagy for survival; however, it is not fully understood how. In this issue of the JCI, Cheong and colleagues demonstrate that RAS-dependent elevation of casein kinase 1α (CK1α) negatively regulates autophagy at the level of autophagy gene transcription. Moreover, combined inhibition of both CK1α and autophagy reduced proliferation of RAS-driven tumors. The results of this study provide insight into the connection between mutant RAS and autophagy, and suggest targeting CK1α as a potential therapeutic strategy to modulate autophagy in RAS-driven cancers.
A HELP TO HEMOGLOBIN DETERMINATION.
Authors: MATHEW A. REASONER
Journal: JAMA (1907)

The following method is suggested as a help to more accurate results with the Gower, Sahli and Haldanes hemoglobinometers. So far as I know it has not been otherwise described or used. The beginner will frequently have trouble in determining the exact point when the dilution tube reaches the standard color. This difficulty is due partly to reflections and the lens effect of the tube as well as to distractions of the surroundings and is, of course, increased in those having a defective color sense. I suggest the use of two mailing tubes 2½ inches in diameter and 14 inches long, coated black on the inside and one end covered (the objective) with black paper having a pin-hole orifice centrally located. Three inches back from this end, in each mailing tube, an opening is made which will just permit the standard and dilution tubes to enter at right angles (see illustration).
Prevention of Antibiotic Resistance in Hospitals
Authors: James R. Johnson
Journal: Annals of Internal Medicine (2002)

Letters15 January 2002Prevention of Antibiotic Resistance in HospitalsJames R. Johnson, MDJames R. Johnson, MDUniversity of Minnesota; Minneapolis, MN 55417Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-2-200201150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Kollef and Fraser (1) discussed adverse clinical outcomes associated with infections caused by antibiotic-resistant organisms. A factor other than unwitting undertreatment and enhanced virulence that may contribute significantly to such outcomes is the underlying status of the host. Many of the characteristics that predict acquisition of an antibiotic-resistant infection, such as prolonged hospital stay or prior receipt of antibiotics (for a previous infection), are markers for sicker hosts and hence themselves predict poor outcomes even in the absence of an antibiotic-resistant pathogen. Because patients cannot be randomly assigned to infection with a susceptible versus a resistant pathogen, ...Reference1. Kollef MH, Fraser VJ. Antibiotic resistance in the intensive care unit. Ann Intern Med. 2001;134:298-314. [PMID: 11182841] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Minnesota; Minneapolis, MN 55417 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAntibiotic Resistance in the Intensive Care Unit Marin H. Kollef and Victoria J. Fraser Prevention of Antibiotic Resistance in Hospitals Nina Singh and Victor L. Yu Prevention of Antibiotic Resistance in Hospitals Marin Kollef Metrics Cited ByNosocomial Antibiotic Resistance in GNB at the ICUsVerfassungstraditionen: Deutschland, Frankreich und Vereinigtes Königreich 15 January 2002Volume 136, Issue 2Page: 173KeywordsAntibiotic resistanceAntibioticsCohort studiesPathogens ePublished: 15 January 2002 Issue Published: 15 January 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Thyroid Hormone Understanding Branches Out: Insights into PBDE Impacts on Brain Development
Authors: Kellyn S. Betts
Journal: Environmental Health Perspectives (2011)

Polybrominated diphenyl ether (PBDE) flame retardants and their hydroxylated metabolites are structurally similar to thyroid hormone.A detailed study now provides one of the most insightful assessments to date of how environmentally relevant levels of PBDEs may impair brain development by interfering with thyroid hormone receptor (TR)-mediated transcription [EHP 119(2):168-175; Ibhazehiebo et al.].PBDEs were used for decades as flame retardants in a wide variety of consumer and household goods, and U.S. citizens are
Unusual Bone Scan Presentation in Osteomalacia: Symmetrical Uptake-A Suggestive Sign
Authors: BHURJI N. SINGH, STEWART M. SPIES, SHARAD P. MEHTA, B ADRIAN KESALA, JAMES L. QUINN
Journal: Clinical Nuclear Medicine (1978)

Osteomalacia presents radiographically as deossification, coarsening of the trabecular pattern, and pseudofractures. Contrary to the usual bone scan manifestation of osteomalacia, consisting of a generalized increase in periarticular radionuclide accumulation and pronounced costochondral junctional uptake, this report describes an unusual bone scan presentation with negative radiographic studies showing only some deossification. Symmetric distribution of the focal lesions is considered a suggestive sign of osteomalacia.
Expression of the α5 integrin gene in corneal epithelial cells cultured on tissue-engineered human extracellular matrices
Authors: Jennifer Lake, Karine Zaniolo, Manon Gaudreault, Patrick Carrier, Alexandre Deschambault, Richard Bazin, Lucie Germain, Christian Salesse, Sylvain L. Guérin
Journal: Biomaterials (2013)
Effects of an 18 week walking programme on cardiac function in previously sedentary or relatively inactive adults.
Authors: K Woolf-May, S Bird, A Owen
Journal: British Journal of Sports Medicine (1997)

OBJECTIVE: To investigate the effects of an 18 week walking programme upon cardiac function. METHODS: 29 sedentary or relatively inactive but otherwise healthy subjects (15 walkers and 14 controls, aged 40-68 years) completed the study. The walkers completed a progressive 18 week walking programme which required an estimated average energy expenditure of 900 kcal week-1 for the total duration of the study and 1161 kcal week-1 during the final six weeks. Walking was carried out at an intensity of 67.8 (SD 4.99)% of maximum oxygen consumption and 73.8(6.99%) of maximum heart rate. Before and after the intervention all subjects underwent an M mode echocardiogram, graded treadmill walking test, and step test for the assessment of aerobic fitness. RESULTS: After 18 weeks the results of the control group showed no change in any of the variables measured while the walkers showed a statistically significant increase in the velocity of relaxation of the longitudinal myocardial fibres of the left ventricle and a decrease in heart rate measured during the step tests, indicating an improvement in aerobic capacity. CONCLUSIONS: Walking promotes improvements in cardiovascular fitness. Moderate forms of exercise may improve cardiac function.
Book: Dobson's Complaint: The Story of the Chester Porphyria
Authors: H. Crimlisk
Journal: BMJ (1999)

Ed Giles R Youngs Royal College of Physicians, £18.50, pp 200 ISBN 1 86016 047 6 ——————— Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> There are many aspects of medical disorders that fascinate doctors: the application of the latest scientific techniques, complex biochemical mechanisms, the detective work involved in teasing out a complex history, the personal strengths that emerge when tragedy strikes, and the thrill of finding a new disorder. This book covers all these features and more about one of the rarer variants of porphyria—Chester porphyria, which results from a combination of the deficits found in the commoner acute intermittent porphyria and variegate … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Abstract LB-237: <i>In vitro</i> and <i>in vivo</i> characterization of CPI-267203, a potent Inhibitor of bromodomain-containing proteins
Authors: Emmanuel Normant, Richard Cummings, Steven Bellon, Christopher Bailey, Brian Albrecht, Michael Hewitt, Eneida Pardo, Robert Campbell, Hari Jayaram, Florence Poy, Peter Sandy, Pranoti Gangurde
Journal: Cancer Research (2012)

Abstract The transcription factor c-Myc regulates diverse biological processes including growth, proliferation, differentiation, quiescence, and senescence or apoptosis. c-Myc proto-oncogene overexpression has been implicated in the genesis of many human malignancies. Identification of compounds that selectively and potently inhibit the expression of c-Myc hence could be beneficial for the treatment of these diseases. We and others have recently shown that inhibiting the binding of bromodomain-containing proteins such as Brd4 to their acetylated histone substrates leads to the specific suppression of c-Myc transcription. We report here the characterization of CPI-267203, a potent, selective and competitive inhibitor of BET domain proteins (Brd4 IC50 = 26 nM and CBP IC50 = 6.0 uM). In vitro, this molecule inhibits IL-6 production (EC50 = 11 nM) induced by lipopolysaccharide (LPS) in acute monocytic leukemia cells (THP1) and c-Myc mRNA production (EC50 = 27 nM) in Burkitt lymphoma cells (Raji). c-Myc mRNA and protein levels decline as early as 4hrs after treatment with CPI-267203, leading to cell cycle arrest and apoptosis. In vivo, CPI-267203 has 84% oral bioavailability and a plasma half-life of 1.9 h. In a xenograft model of human acute myelogenous leukemia (MV4:11), CPI-267203 inhibits the production of c-Myc mRNA and protein, inhibits tumor growth, and triggers tumor apoptosis. Reduction of c-Myc protein levels can also be detected in the normal skin of treated animals, suggesting that the level of c-Myc in the skin might be a useful surrogate pharmacodynamic marker to aid clinical trials. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-237. doi:1538-7445.AM2012-LB-237
Saliva test could diagnose cancers
Authors: A. Berger
Journal: BMJ (2000)

Looking for mitochondrial genetic mutations in bodily fluid could be a promising new way to detect cancers. David Sidransky and his team from Johns Hopkins University School of Medicine in Baltimore, Maryland, have discovered that genetic mutations in mitochondrial cells from cancers are highly prevalent and easily detectable in urine, sputum, and bronchial secretions.

Professor Sidransky believes that this observation could provide a powerful molecular marker for non-invasive detection of cancer (Science 2000;287:2017-9).

Mitochondrial DNA is derived from …
Patient With iDEND Syndrome–Related Mutation
Authors: Ana M. Prado-Carro, Joan Calzada-Hernández, Silvia Marín, Roque Cardona-Hernandez, Josep Oriola, Marta Nicolás, Marta Ramon-Krauel
Journal: Diabetes Care (2014)

Mutations on the ATP-sensitive K+ (KATP) channel are the most common cause of permanent neonatal diabetes. Heterozygous gain-of-function mutations in KCNJ11 and ABCC8, encoding respectively for the Kir6.2 and sulfonylurea receptor 1 (SUR1) subunit of the KATP channel, account for the majority of cases of permanent neonatal diabetes (1). Kir6.2 is expressed in the pancreatic β-cell, but also in skeletal muscle, peripheral nerves, and especially in the brain. Specific KCNJ11 mutations also are associated with developmental delay and epilepsy, known as developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome, or in milder forms, intermediate DEND (iDEND). Sulfonylureas improve KATP channel function in the pancreatic β-cell and also in neuronal and muscle cells, and could potentially play a role in the treatment and/or prevention of such neurologic manifestations.

Our patient has a KCNJ11 mutation associated with iDEND syndrome and was successfully switched to glyburide early. The patient …