tbuckley/cabot-search huggingface dataset:
Increased Frequency of Apo E-ND Phenotype and Hyperapobetalipoproteinemia in Normolipidemic Subjects with Xanthelasmas of the Eyelids
Authors: PHILIPPE DOUSTE-BLAZY
Journal: Annals of Internal Medicine (1982)

Apolipoprotein E isomorphs in very low density lipoproteins and apolipoprotein B of low density lipoproteins were measured in the plasma of normolipidemic subjects with xanthelasmas of the eyelids and in appropriate control groups. All patients tested in the experimental group had an apolipoprotein EII to apolipoprotein EIII ratio typical of the heterozygous state for familial dysbetalipoproteinemia, a hyperapobetalipoproteinemia, or both. Some patients had concomitant atherosclerosis. This is the first report of an increased frequency of the apolipoprotein E-ND phenotype in normolipidemic xanthelasma. This condition should not be dismissed as benign; tissue lipid deposition in the absence of hyperlipidemia might be related to the presence of lipoproteins of abnormal composition with an enhanced atherogenic potential.
A CONTROLLED STUDY OF PERSONALITY RELATIONSHIPS IN MOTHERS OF SCHIZOPHRENIC MALE PATIENTS
Authors: CURTIS T. PROUT, MARY ALICE WHITE
Journal: American Journal of Psychiatry (1950)

1. Twenty-five mothers of hospitalized schizophrenic male patients (experimental group) and 25 mothers of nonhospitalized and nonschizophrenic males (control group) were interviewed and Rorschachs administered. There was little demonstrable difference in the life histories between these 2 groups, except a more frankly critical attitude and a more gregarious interest on the part of our control group. 2. The Rorschach data suggested a higher level of drive and a more outgoing adjustment in our control group. 3. The personality data evidenced a more ambitious, aggressive, and successful feeling as individuals, in the control mothers. This, we feel, had resulted in a more free and realistic relationship with their sons. 4. While on superficial examination it would appear that the patients' mothers are "overprotective and oversolicitous," they did not demonstrate these characteristics as such in this study. We feel that their lack of being persons in their own right may have caused them to live out their own emptiness in the lives of their stand-in sons, in so far as the sons had permitted this. 5. The therapeutic implication of this study is that an independent life for the mother is indicated in order for the son to have a life of his own. 6. This study provided no information as to how the sons had reacted to their mothers' attitudes, nor any estimate of what other stresses might have been significant in their illness. Furthermore, this study did not show that the observed differences were indigenous to schizophrenia.
Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease
Authors: Suk See De Ravin, Kol A. Zarember, Debra Long-Priel, King C. Chan, Stephen D. Fox, John I. Gallin, Douglas B. Kuhns, Harry L. Malech
Journal: Blood (2010)
Radiological Evaluation of Pott Puffy Tumor
Authors: Robert G. Wells
Journal: JAMA (1986)

THE POTT puffy tumor represents frontal osteomyelitis with subperiosteal (pericranial) abscess, secondary to frontal sinusitis. Sir Percival Pott, an English surgeon, recognized in 1760 that "inflammation of the dura mater and the formation of matter between it and the skull, in consequence of contusion, is generally indicated by one sign, a puffy, circumscribed indolent tumor of the scalp, and a spontaneous separation of the pericranium from the skull under such tumor."<sup>1</sup>Pott puffy tumor is one of several potential complications of infection of a frontal sinus. Although a significant decrease in the incidence of disease of the frontal sinuses has occurred since the advent of antibiotics, frontal sinusitis still occurs in clinical practice and may follow a clinical course not unlike that observed during the preantibiotic era. Cranial and intracranial extension from infection of a frontal sinus may cause osteomyelitis, cavernous sinus thrombosis, meningitis, subdural empyema, and subperiosteal, epidural,
Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester
Authors: Eliézer Jäger, Alessandro Jäger, Petr Chytil, Tomáš Etrych, Blanka Říhová, Fernando Carlos Giacomelli, Petr Štěpánek, Karel Ulbrich
Journal: Journal of Controlled Release (2012)
Age should be no barrier to surgery, says report
Authors: J. Wise
Journal: BMJ (2012)

Decisions about a patient’s suitability for surgery should be based on their overall health or biological age rather than their chronological age, warns a new report from the Royal College of Surgeons and the charity Age UK.1

The authors examined treatment rates across eight areas of surgery and looked at how these varied with age. Among the examples cited in the report was the finding that the incidence of breast cancer peaked in patients in the 85 years or more age group while the surgery rate peaked in the mid-60s and then fell sharply from the age of 70.

Similarly, the rate of elective knee replacement and hip replacement surgery for patients in their late 70s or more dropped consistently from 2008 …
You Are My Enemy
Authors: John T. Distelhorst
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P1045 ESTIMATING THE PROBABILITY OF RESPONSE TO PEG-INTERFERON THERAPY IN HBeAg-POSITIVE CHRONIC HEPATITIS B: THE EPIC-B STUDY
Authors: M.J. Sonneveld, V.W.-S. Wong, T. Piratvisuth, J.-D. Jia, S. Zeuzem, E. Gane, Y.-F. Liaw, Q. Xie, H.L.-Y. Chan, B.E. Hansen, H.L. Janssen
Journal: Journal of Hepatology (2014)
Reduction of telomeric repeats as a possible predictor for development of hepatocellular carcinoma: Convenient evaluation by slot-blot analysis
Authors: Osamu Isokawa, Takeshi Suda, Yutaka Aoyagi, Hirokazu Kawai, Takashi Yokota, Toru Takahashi, Kazuhiro Tsukada, Takeaki Shimizu, Shigeki Mori, Yoichi Abe, Yasafumi Suzuki, Minoru Nomoto, Yusaku Mita, Masahiko Yanagi, Hirotaka Igarashi, Hitoshi Asakura
Journal: Hepatology (1999)

Hepatocellular carcinoma (HCC) mainly arises from the liver with chronic inflammation. Because telomere reduction reflects replicative history in somatic cells, we analyzed the possibility that liver tissues surrounding HCC consist of the cells carrying substantial reduction of telomere. We studied 20 HCC and surrounding noncancerous liver tissues (SL) obtained by surgical resection, and 10 laparoscopically obtained needle biopsy specimens of the liver with chronic inflammation including no overt HCC (CI). Five liver tissues without chronic liver diseases (ND) were also examined. Extracted genomic DNAs were blotted on a nylon membrane, and probed at first with radio-labeled d(TTAGGG) 3 and reprobed with radio-labeled d(CCT) 7 . The intensity caused by d(TTAGGG) 3 was divided by that of d(CCT) 7 . The ratio was defined as telomeric repeats content (TC). Dilution experiments reproducibly revealed almost the same TC. The reduction rate of telomere length through aging estimated by regression analysis of TC was 0.62% per year. Concomitant analyses of TC and average telomere length revealed that both values were significantly correlated ( r = .45; P = .009). To compare TC in the liver with respect to chronic inflammation, the value was divided by TC in peripheral blood leukocytes (PBL) from the same donor. The ratio was defined as relative TC (RTC). There was a statistically significant decrease of RTC in CI compared with that in ND ( P = .03). Furthermore, RTC in SL was significantly lower than that in CI ( P = .0001). These observations suggest that RTC value in liver tissues may digitally indicate a replicative history of hepatocytes under chronic inflammation, and a risk of HCC development.
Left ventricular SERCA2a gene down‐regulation does not parallel ANP gene up‐regulation during post‐MI remodelling in rats
Authors: Fabrice Prunier, Ying Chen, Barnabas Gellen, Michéle Heimburger, Christine Choqueux, Brigitte Escoubet, Jean‐Baptiste Michel, Jean‐Jacques Mercadier
Journal: European Journal of Heart Failure (2005)
Procedures for obtaining informed consent: Authors' reply
Authors: R J Simes, M H N Tattersall
Journal: BMJ (1986)

The urge to demand, pour, and drink water at the time of an attack was encountered in 20 patients who had seizures with complex partial symptomatology. Two patients were studied with bitemporal stereotaxically implanted depth electrodes. Drinking was associated with electrographic and clinical seizures starting in the amygdala, hippocampus, and parahippocampal gyrus. Sometimes, this was the only clinical manifestation of an attack, and its significance would not have been recognized without depth recording. Ictal drinking was never encountered in patients without electroencephalographic evidence of temporal epileptic abnormality, and therefore seems to have localizing significance.
Gene Delivery of a Mutant TGFβ3 Reduces Markers of Scar Tissue Formation After Cutaneous Wounding
Authors: Simon N Waddington, Rachel Crossley, Vicky Sheard, Steven J Howe, Suzanne MK Buckley, Lynda Coughlan, David E Gilham, Robert E Hawkins, Tristan R McKay
Journal: Molecular Therapy (2010)

The transforming growth factor-β (TGFβ) family plays a critical regulatory role in repair and coordination of remodeling after cutaneous wounding. TGFβ1-mediated chemotaxis promotes the recruitment of fibroblasts to the wound site and their resultant myofibroblastic transdifferentiation that is responsible for elastic fiber deposition and wound closure. TGFβ3 has been implicated in an antagonistic role regulating overt wound closure and promoting ordered dermal remodeling. We generated a mutant form of TGFβ3 (mutTGFβ3) by ablating its binding site for the latency-associated TGFβ binding protein (LTBP-1) in order to improve bioavailability and activity. The mutated cytokine is secreted as the stable latency-associated peptide (LAP)-associated form and is activated by normal intracellular and extracellular mechanisms including integrin-mediated activation but is not sequestered. We show localized intradermal transduction using a lentiviral vector expressing the mutTGFβ3 in a mouse skin wounding model reduced re-epithelialization density and fibroblast/myofibroblast transdifferentiation within the wound area, both indicative of reduced scar tissue formation.
Thomas (“Tom”) John Parkinson
Authors: Charlotte J S Duff
Journal: BMJ (2006)

Organization Dr Lee Jong-wook continued the revival of the agency begun by his predecessor, Gro Harlem Brundtland.Having taken over from the formidable Norwegian in 2003, Dr Lee continued to push health to the top of the global political agenda, winning plaudits for his style, which was based on action not words.He entered office as the threat of severe acute respiratory syndrome was subsiding, and it was bird flu-a pandemic that has yet to emerge-that was to dominate much of his time as leader of WHO.However, in the long term it is likely to be his bold, if ultimately unattainable, pledges on HIV treatment that will be remembered.Apart from his expertise in public health Dr Lee was a consummate politician-a characteristic that raised a few eyebrows at the time of his candidature.A number of health experts remarked that Dr Lee had acted more like a politician than a scientist in his extensive lobbying for the top job.As part of his strategy to get elected he persuaded more than 50 members of the US Congress to write to the US government backing his candidacy.He also remarked in an interview later that year that "you can't make it to this position without being a politician."Conversely, some commentators thought that this poor public speaker with a modest demeanour would be out of his depth on the world stage.But he was soon able to build personal contacts with George Bush, Jacques Chirac, and China's president, Hu Jintao.This July he had been due to address the G8 summit in St Petersburg at the personal invitation of Vladimir Putin.Dr Lee understood that the steps he had publicly avowed he would take against infectious diseases and tobacco related illnessfrom which his father had died-would not be possible without the support of world leaders.He declared that tuberculosis, polio, malaria, and above all, AIDS, would be key battlegrounds during his leadership.He introduced the "3 by 5" campaign, in which WHO pledged that three million HIV patients-most of whom were in the developing world-would have access to
Reported sun exposure, attitudes to sun protection and perceptions of skin cancer risk: a survey of visitors to Cancer Research UK’s SunSmart campaign website
Authors: B.L. Diffey, Z. Norridge
Journal: British Journal of Dermatology (2009)

Journal Article Reported sun exposure, attitudes to sun protection and perceptions of skin cancer risk: a survey of visitors to Cancer Research UK's SunSmart campaign website Get access B.L. Diffey, B.L. Diffey Dermatological Sciences, Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne NE2 4HH, U.K. Correspondence: Brian Diffey. E‐mail: b.l.diffey@ncl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar Z. Norridge Z. Norridge Cancer Research UK, 61 Lincoln's Inn Fields, London WC2A 3PX, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 6, 1 June 2009, Pages 1292–1298, https://doi.org/10.1111/j.1365-2133.2009.09149.x Published: 01 June 2009
The Effect of Selective Intestinal Decontamination on the Hyperdynamic Circulatory State in Cirrhosis
Authors: Brindhesha Rasaratnam, David Kaye, Garry Jennings, Francis Dudley, Jaye Chin-Dusting
Journal: Annals of Internal Medicine (2003)

Peripheral vasodilatation is central to the pathogenesis of the accompanying hyperkinetic circulatory state and portal hypertension in cirrhotic patients. Selective intestinal decontamination with norfloxacin has been demonstrated to partially correct nitric oxide production in the forearm vasculature of cirrhotic patients.To examine the effects of selective intestinal decontamination on regional and systemic hemodynamics in cirrhotic patients.Randomized, double-blind, placebo-controlled, crossover study.Alfred Hospital, Melbourne, Australia.14 patients with alcohol-related cirrhosis and 14 matched healthy controls.Norfloxacin, 400 mg twice daily, for 4 weeks.Venous occlusion plethysmography was used to determine forearm blood flow. Cardiac output and the hepatic venous pressure gradient were determined after cardiac catheterization. Glomerular filtration rate was assessed by measuring inulin clearance. Serum levels of endotoxin were determined by chromogenic Limulus amebocytelysate assay.Norfloxacin significantly diminished serum endotoxin levels (average change, -2.14 EU/mL [95% CI, -3.6 to -0.68 EU/mL]). Derived systemic vascular resistance increased significantly with norfloxacin (2.94 units [CI, 0.74 to 5.11 units]) and was accompanied by an increase in mean arterial pressure (8.70 mm Hg [CI, 2.65 to 14.73]), a trend toward decreased cardiac output (-1.207 L/min [range, 0.05 to -2.37 L/min]), a decrease in forearm blood flow (-0.99 mL/100 mL per min [CI, -1.80 to -0.17 mL/100 mL per min]), and a trend toward reduced hepatic venous pressure gradient (-2.43 mm Hg [CI, -5.2 to 0.34 mm Hg]). Norfloxacin did not significantly alter glomerular filtration rate.Selective intestinal decontamination with norfloxacin partially reverses the hyperdynamic circulatory state in cirrhotic patients without harming splanchnic or renal hemodynamics.
Health needs assessment: Epidemiological issues in health needs assessment
Authors: R. Williams, J. Wright
Journal: BMJ (1998)

This is the second in a series of six articles describing approaches to and topics for health needs assessment, and how the results can be used effectively Series editor: John Wright The first article in this series explained the importance of health needs assessment in the context of planning and delivering health care to populations.1 It mentioned the "epidemiological approach" to health needs assessment—the traditional public health approach of describing need in relation to specific health problems using estimates of the incidence, prevalence, and other surrogates of health impact derived from studies carried out locally or elsewhere. This approach has been be extended to the consideration, alongside these measures, of the ways in which existing services are delivered and the effectiveness and cost effectiveness of interventions intended to meet the needs thus described (fig 1).2 This is a logical extension as there is little point in estimating the burden of ill health (except for determining priorities for future research) if nothing can be done to reduce it. Epidemiology has been defined as "the study of the distribution and determinants of health-related states or events in specific populations and the application of this study to control of health problems."3 It tends, for the most part, to use the "medical model" of health need, viewing need in terms of the occurrence of specific diseases and health related states rather than client groups. Descriptive epidemiology (as opposed to analytical epidemiology—the investigation of the determinants of health related states or events) describes the occurrence of disease in terms of person, place, and time:
Two-dimensional echocardiographic visualization of the left coronary artery in anomalous origin of the left coronary artery from the pulmonary artery. Pre- and postoperative studies.
Authors: E A Fisher, B Sepehri, B Lendrum, J Luken, S Levitsky
Journal: Circulation (1981)

Three young children with anomalous origin of the left coronary artery (LCA) from the pulmonary artery were studied by two-dimensional echocardiography. The LCA was shown to be in confluence with the left posterior aspect of th pulmonary artery root in the two patients studied preoperatively. In one of these patients, and in another patient 2 years after surgery, studied after direct surgical implantation of the LCA to the aorta, the LCA was shown to be confluent with the left anterior aspect of the aortic root. In all, the LCA could be followed beyond the branching point. This study demonstrates the feasibility of noninvasive diagnosis of anomalous origin of the LCA from the pulmonary artery by direct visualization with two-dimensional echocardiography.
Pediatric Care of the ICN Graduate
Authors: Jon F. Watchko
Journal: JAMA (1989)

Frank Oski, MD, chairman and Givens Professor of Pediatrics at The Johns Hopkins University School of Medicine, has stated on numerous occasions that neonatologists need to be "good farmers" as well as "good firemen"—tending their harvest of low-birth weight infants over the long growing season with great care. Efforts in this regard have focused on optimizing long-term neurodevelopmental, behavioral, and pulmonary outcomes. Guidelines to direct care givers in such endeavors have been numerous and have dated as far back as 1934 with the work of Hess and coworkers entitled The Physical and Mental Growth of<i>Prematurely Born Children</i>.<sup>1</sup>The most recent contribution to this growing literature is Roberta A. Ballard's<i>Pediatric Care of the ICN Graduate</i>. Dr Ballard's text is unique in its scope and comprehensiveness as well as its focus—that being the "critical post-hospital period of convalescence for the recipients of neonatal intensive care" (p xii). Chapters are
Swedes insured against adverse drug effects
Authors: S. Osterberg
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Interpretation of Laboratory Tests
Authors: Oscar D. Ratnoff
Journal: JAMA (1969)

In teaching clinical medicine, all of us are accustomed to moralize to our students that the good physician makes a diagnosis by listening to the patient's story and then examining him. The laboratory, we tell them, is a crutch with which we affirm our bedside impression. Of course, whatever the didactic value of such dogma, it is in essence a call for a return to that simpler life when we lived in a rural society and a good glass of beer cost a nickel. In reality, diagnosis can be based only upon objective evidence; all else is surmise. Whatever the history or physical examination reveals, it is study of the peripheral blood smear and bone marrow that affirms that the patient has chronic myeloid leukemia. Our clinical impressions tell us what to look for, but the laboratory tells us what we have found. When we are still without adequate laboratory
Practical implications of liver and heart iron load assessment by T2*‐MRI in children and adults with transfusion‐dependent anemias
Authors: Sarah Deborah Chirnomas, Marnix Geukes‐Foppen, Kristen Barry, Jennifer Braunstein, Leslie A. Kalish, Ellis J. Neufeld, Andrew J. Powell
Journal: American Journal of Hematology (2008)

Abstract This study examined the relationship between hepatic and myocardial iron concentration, assessed by T2*‐MRI in 66 patients (3–82 years) with transfusion‐dependent anemias and thalassemia intermedia, to determine whether hepatic iron levels alone suffice for chelation adjustments. We found a poor correlation between hepatic and myocardial iron ( r = 0.10, P = 0.43) and identified a subgroup (14%) with increased myocardial iron without a matched degree of hepatic hemosiderosis. Left ventricular ejection fraction was insensitive for detecting elevated myocardial iron. These findings were present in both adult and pediatric patients. We recommend therapeutic monitoring of iron burden by evaluation of both liver and myocardial iron with T2*‐MRI. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.