tbuckley/cabot-search huggingface dataset:
Combined Nerve and Tendon Injury in the Palm
Authors: Robert R. Rix
Journal: JAMA (1971)

To the Editor.—  In order to qualify as a mid-palm injury the distal cut end of the flexor profundus tendon must lie in the narrow zone between the digital sheath and the carpal tunnel, with the finger fully extended. This is not a common injury (about 10% of flexor tendon lacerations), but when it does occur it is a major problem because it is almost always accompanied by severance of one or more digital nerves.  There is no general agreement on handling combined nerve and tendon injuries in clean-cut wounds of the palm. Most authorities recommend immediate primary repair of both structures. While this is undoubtedly ideal treatment, it is also difficult to accomplish. If the nerve injury is repaired first, the manipulations incident to the tendon suture may endanger the delicate nerve repair. If the tendon injury is repaired first, and the finger is flexed to take the strain
Nephrotic syndrome during treatment with interferon.
Authors: P Selby, J Kohn, J Raymond, I Judson, T McElwain
Journal: BMJ (1985)

Adverse reactions develop in roughly one third of patients treated with gold, the proportion varying from 5",, to 80O, in several reported series.'Eosinophilia occurs in roughly 5O, of patients and has been directly correlated with the development of gold toxicity.2Vasomotor reactions to gold are not uncommon, but whether they indicate the development of more serious gold toxicity is unknown.Neurological complications, including peripheral neuropathy, myokymia, and a syndrome like the Guillain-Barre syndrome,3 have received little attention even in major textbooks of rheumatology.4Encephalopathy has been reported: McAuley et al described a patient who recovered fully one month after treatment with gold was stopped.0The severity of the illness in our patient, with residual neurological deficit nearly five months afterwards, shows the serious side effects that may occur during chrysotherapy.
Small Australian town is model for community campaigns against obesity
Authors: R. Moynihan
Journal: BMJ (2008)

The small town of Colac in rural Australia is attracting national and international attention for its approach to fighting childhood obesity, and reducing health inequalities.

Two hours west of Melbourne, with 11 000 inhabitants, Colac is the site of a long term community-wide campaign called Be Active Eat Well, funded by the state government of Victoria.

Colac, a small Australian town, is attracting national and international attention for its approach to fighting childhood obesity, and reducing health inequalities. Ray Moynihan talks to some of …
Viable Embryos from Injection of Round Spermatids into Oocytes
Authors: Jan Tesarik, Carmen Mendoza, Jacques Testart
Journal: New England Journal of Medicine (1995)

To the Editor: By injecting sperm into the cytoplasm of an oocyte1 it is now possible to achieve fertilization and pregnancy in cases of obstructive azoospermia or severe oligozoospermia and asthen...
Fiberoptic-Dye Dilution Method for Measurement of Cardiac Output
Authors: HENRY R. WAGNER, WALTER J. GAMBLE, WILLIAM H. ALBERS, PAUL G. HUGENHOLTZ
Journal: Circulation (1968)

A new method for the measurement of cardiac output has been tested in 69 patients undergoing catheterization of the right and left sides of the heart. It is based on the recently described fiberoptic hemoreflection method. In order to verify the validity of these measurements, correlations with stroke indices determined by the Fick principle and by biplane angiocardiography were also carried out. Details of the biplane angiocardiographic technique and of the fiberoptic calibration methods are given. Comparisons were carried out in 37 instances between the results after injections in the pulmonary artery (mean stroke index, 40.8 ml/m 2 ) and in the left ventricle (mean, 42.9 ml/m 2 ). Good agreement was found, r=0.930, with a mean difference of 2.1 ml/m 2 . Stroke indices by fiberoptics (FO) were first compared with those obtained by the standard Fick method. In 100 determinations the mean stroke index by FO was 45.7 ml/m 2 , and Fick 49.0 ml/m 2 (r=0.859; confidence limits, 0.77&lt; p &lt;0.93). Correlations were then carried out in 42 instances between stroke index by FO (mean, 49.1 ml/m 2 ) and by angiocardiography (mean, 48.2 ml/m 2 , r=0.799; confidence limits, 0.65&lt; p &lt;0.90). Various factors influencing the angiocardiographic method for determining stroke index are discussed. It is concluded, that the fiberoptic-indicator dilution method is an accurate system to determine cardiac output regardless of the site of injection (LV or PA). Its versatility, the lack of need for blood withdrawal, and the generally satisfactory agreement with angiocardiographic or standard Fick method recommend its general application when cardiac output determinations are required during the process of cardiac catheterization, provided sampling is carried out in the aorta.
Medical Registration in England.
Authors: A Yankee
Journal: JAMA (1889)

child suffered no more, I advised that nothing be done.I heard no more from the case until Janu¬ ary i, 1889, when the child was brought to me to examine a tender spot in the lumbar muscles, about .inch to the left of the spine and about 3 inches above the crest of the ilium.I found a
Dextropropoxyphene induced hepatotoxicity mimicking biliary tract disease.
Authors: M F Bassendine, K W Woodhouse, M Bennett, O F James
Journal: Gut (1986)

Three patients are described with recurrent jaundice, upper abdominal pain and rigors attributable to dextropropoxyphene hepatotoxicity. The diagnosis was established in each patient by rechallenge; post challenge hepatic histology is reported in two. Twelve previous patients with probable dextropropoxyphene hepatic toxicity have been described and are reviewed. In 10 of the 15 patients, a clinical diagnosis of gall stone disease was made. Liver function tests are usually hepatitic shortly after challenge, but more cholestatic after a few days. No fatalities have been described, but as dextropropoxyphene is widely available in many different analgesic preparations possible toxicity should be considered in patients with relapsing jaundice mimicking biliary disease, in whom gall stones have been excluded.
Sleep and Exertional Periodic Breathing in Chronic Heart Failure
Authors: Ugo Corrà, Massimo Pistono, Alessandro Mezzani, Alberto Braghiroli, Andrea Giordano, Paola Lanfranchi, Enzo Bosimini, Marco Gnemmi, Pantaleo Giannuzzi
Journal: Circulation (2005)

Sleep and exertional periodic breathing are proverbial in chronic heart failure (CHF), and each alone indicates poor prognosis. Whether these conditions are associated and whether excess risk may be attributed to respiratory disorders in general, rather than specifically during sleep or exercise, is unknown.We studied 133 CHF patients with left ventricular ejection fraction (LVEF) < or =40%. During 1170+/-631 days of follow-up, 31 patients (23%) died. Nonsurvivors had higher New York Heart Association class, ventilatory response (ve/vco2 slope), and apnea-hypopnea index (AHI) and lower peak vo2 (all P<0.01); lower LVEF and prescription of beta-blockers, and shorter transmitral deceleration time (all P<0.05). Exertional oscillatory ventilation (EOV), established by cyclic fluctuations in minute ventilation that persisted for > or =60% of exercise duration with an amplitude > or =15% of the average resting value, was significantly more frequent in nonsurvivors (42% versus 15%, P<0.01). Multivariable analysis selected AHI (hazard ratio [HR] 5.66, 95% CI 2.3 to 19.9, P<0.01), peak vo2 (HR 0.93, 95% CI 0.90 to 0.97, P<0.01), and beta-blocker prescription (HR 0.34, 95% CI 0.13 to 0.87, P<0.05) as predictors of cardiac events. The best cutoff for AHI was >30/h. EOV was significantly related to AHI >30/h (chi2 14.6, P<0.01): 78% of EOV patients showed AHI >30/h. Multivariable analysis, including breathing disorders alone (EOV, AHI >30/h) or in combination (EOV plus AHI >30/h), selected combined disorders as the strongest predictor of events (HR 6.65, 95% CI 2.6 to 17.1, P<0.01).In CHF, EOV is significantly associated with AHI >30/h. Although each breathing disorder alone is linked to total mortality, their combination has a crucial prognostic burden.
Importance of trial design in studies using high-dose intravenous immunoglobulin: reply from authors
Authors: C. Paul, L. Dubertret
Journal: British Journal of Dermatology (2003)

Journal Article Importance of trial design in studies using high‐dose intravenous immunoglobulin: reply from authors Get access C. Paul, C. Paul Department of Dermatology, Mulhouse General Hospital, 68100 Mulhouse, and Search for other works by this author on: Oxford Academic Google Scholar L. Dubertret L. Dubertret Department of Dermatology, Saint Louis University Hospital, 75010 Paris, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 148, Issue 6, 1 June 2003, Pages 1285–1286, https://doi.org/10.1046/j.1365-2133.2003.05373.x Published: 01 June 2003
A Child with WHIM Syndrome (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) and a Family History of Cervical Dysplasia Suggesting Generalized Susceptibility to Human Papilloma Virus Serotypes
Authors: L.E. Montelibano, K. Paris, R. Howes, R.U. Sorensen
Journal: Journal of Allergy and Clinical Immunology (2007)
Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss
Authors: Kevin D. Brown, Sadia Maqsood, Jing-Yi Huang, Yong Pan, William Harkcom, Wei Li, Anthony Sauve, Eric Verdin, Samie R. Jaffrey
Journal: Cell Metabolism (2014)
Nitric oxide does not mediate flow induced endothelium dependent arterial dilatation in the cat
Authors: A. M Melkumyants, S. A Balashov, A. N Klimachev, S. P Kartamyshev, V. M Khayutin
Journal: Cardiovascular Research (1992)

Objective: The aim was to determine whether the endothelium derived nitric oxide formed from L-arginine is the factor which mediates flow induced dilatation of conduit arteries. Methods: Changes in diameter of feline femoral artery caused by blood flow rate increases, acetylcholine, and ATP were recorded during perfusion with blood in situ before and after the inhibition of endothelium derived nitric oxide synthesis by NG-nitro-L-arginine methyl ester and NG-monomethyl-L-arginine. Fourteen anaesthetised cats of either sex, weight 2.6-3.9 kg, were used for the studies. Results: Intravenous administration of NG-nitro-L-arginine methyl ester and NG-monoethyl-L-arginine in doses 10 and 30 mg·kg−1 evoked a rise in mean systemic arterial pressure, constriction of the femoral artery, and considerable decrease in acetylcholine and ATP induced dilatation. However, it did not affect the dilator response induced by increased blood flow rate. Conclusions: Flow induced endothelium dependent arterial dilatation is not mediated by nitric oxide or, if nitric oxide is still released in response to flow rate increase, it has a source distinct from L-arginine.
Alzheimer's Disease, Apolipoprotein E4, and Gender
Authors: Haydeh Payami, Kim R. Montee, Jeffrey A. Kaye, Thomas D. Bird, Chang En Yu, Ellen M. Wijsman, Gerard D. Schellenberg
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Researchers at Duke University have shown that apolipoprotein<i>E4</i>(apo E) gene dosage correlates with increased risk of Alzheimer's disease (AD).<sup>1</sup>Their study included members of 42 families with late-onset AD (age at onset, &gt;60 years) with known apo E genotype and used Kaplan-Meier survival analysis to estimate the age-of-onset curves for subjects with zero, one, and two<i>E4</i>alleles. The resulting curves revealed a significant dosage effect, where each additional<i>E4</i>allele shifted the onset to an earlier age. We have performed a similar study, which included members of 52 families with late-onset AD (age at onset, &gt;60 years) with known apo E genotype and used Kaplan-Meier survival analysis to estimate the age-of-onset curves for subjects with zero, one, and two<i>E4</i>alleles. Our study included 252 individuals with known age and apo E genotype; 38 were younger than 60 years,
Early coronary reperfusion blunts the procoagulant response of plasminogen activator inhibitor-1 and von Willebrand factor in acute myocardial infarction
Authors: Felicita Andreotti, M.Carla Roncaglioni, David R. Hackett, Mohamed I. Khan, Tessa Regan, Agha W. Haider, Graham J. Davies, Cornelis Kluft, Attilio Maseri
Journal: Journal of the American College of Cardiology (1990)
The Cell-Intrinsic Requirement of Sox6 for Cortical Interneuron Development
Authors: Renata Batista-Brito, Elsa Rossignol, Jens Hjerling-Leffler, Myrto Denaxa, Michael Wegner, Véronique Lefebvre, Vassilis Pachnis, Gord Fishell
Journal: Neuron (2009)
Biodegradable Thermogelling Polymers: Working Towards Clinical Applications
Authors: Qing Qing Dou, Sing Shy Liow, Enyi Ye, Rajamani Lakshminarayanan, Xian Jun Loh
Journal: Advanced Healthcare Materials (2014)

As society ages, aging medical problems such as organ damage or failure among senior citizens increases, raising the demand for organ repair technologies. Synthetic materials have been developed and applied in various parts of human body to meet the biomedical needs. Hydrogels, in particular, have found extensive applications as wound healing, drug delivery and controlled release, and scaffold materials in the human body. The development of the next generation of soft hydrogel biomaterials focuses on facile synthetic methods, efficacy of treatment, and tunable multi-functionalities for applications. Supramolecular 3D entities are highly attractive materials for biomedical application. They are assembled by modules via various non-covalent bonds (hydrogen bonds, p-p stacking and/or van der Waals interactions). Biodegradable thermogels are a class of such supramolecular assembled materials. Their use as soft biomaterials and their related applications are described in this Review.
Who Adopts Improved Fuels and Cookstoves? A Systematic Review
Authors: Jessica J. Lewis, Subhrendu K. Pattanayak
Journal: Environmental Health Perspectives (2012)

The global focus on improved cookstoves (ICSs) and clean fuels has increased because of their potential for delivering triple dividends: household health, local environmental quality, and regional climate benefits. However, ICS and clean fuel dissemination programs have met with low rates of adoption.We reviewed empirical studies on ICSs and fuel choice to describe the literature, examine determinants of fuel and stove choice, and identify knowledge gaps.We conducted a systematic review of the literature on the adoption of ICSs or cleaner fuels by households in developing countries. Results are synthesized through a simple vote-counting meta-analysis.We identified 32 research studies that reported 146 separate regression analyses of ICS adoption (11 analyses) or fuel choice (135 analyses) from Asia (60%), Africa (27%), and Latin America (19%). Most studies apply multivariate regression methods to consider 7-13 determinants of choice. Income, education, and urban location were positively associated with adoption in most but not all studies. However, the influence of fuel availability and prices, household size and composition, and sex is unclear. Potentially important drivers such as credit, supply-chain strengthening, and social marketing have been ignored.Adoption studies of ICSs or clean energy are scarce, scattered, and of differential quality, even though global distribution programs are quickly expanding. Future research should examine an expanded set of contextual variables to improve implementation of stove programs that can realize the "win-win-win" of health, local environmental quality, and climate associated with these technologies.
German scientists demand a ban on tobacco additives
Authors: Annette Tuffs
Journal: BMJ (2005)

The German Cancer Research Centre (Deutsches Krebsforschungszentrum) last week demanded that certain additives used in tobacco products be banned because they increase the risk of cancer and tobacco addiction, particularly among children and young adults.

Experts from the centre, in Heidelberg, and from the Institute for Law and Economy in Hamburg presented two new publications that analysed internal tobacco industry documents concerning the composition of tobacco products and additives.

They told a press …
Shakespeare or Krebs?: Premedical Education
Authors: Harvey G. Ouzts, Hillary R. Newland
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 November 1985Shakespeare or Krebs?: Premedical EducationHARVEY G. OUZTS, M.D., HILLARY R. NEWLAND, M.D.HARVEY G. OUZTS, M.D.Search for more papers by this author, HILLARY R. NEWLAND, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-5-809_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The baccalaureate education of physicians, its emphasis on science and weakness in the humanities, has been criticized (1, 2). The major contention is that the college curriculum of physicians is narrow and oriented toward entry and performance in medical school, not toward education. These points are discussed in academic centers and generally represent the opinions of educators, university physicians, and medical students. However, the largest number of opinions is represented by the physicians in private practice, who spend less time teaching, writing, and researching. It is on this segment that we base our report.We surveyed the...References1. Physicians for the Twenty-First Century: The GPEP Report: Report of the Panel on the General Professional Education of the Physician and College Preparation for Medicine. Washington, D.C.: Association of American Medical Colleges; 1984. Google Scholar2. BARONDESS J. The GPEP Report: 1. Preparation for medical school [Editorial]. Ann Intern Med. 1985;103:138-9. LinkGoogle Scholar3. THOMAS L. Notes of a biology-watcher: how to fix the premedical curriculum. N Engl J Med. 1978;298:1180-1. CrossrefMedlineGoogle Scholar4. CREDITOR U and CREDITOR M. Curriculum choices of premedical students. J Med Educ. 1982;57:436-41. MedlineGoogle Scholar5. Undergraduate Majors, Emory University Medical School. Anlage, Newspaper of the Emory Medical Community. 1984;17(October):16. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARVEY G. OUZTS, M.D.; HILLARY R. NEWLAND, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFaculty ForumLiterature and medicine: a short course for medical students 1 November 1985Volume 103, Issue 5Page: 809-810KeywordsMedical education ePublished: 1 December 2008 Issue Published: 1 November 1985 PDF downloadLoading ...
Reproduction of epigastric pain of duodenal ulceration by adenosine.
Authors: A H Watt, D J Lewis, J J Horne, P M Smith
Journal: BMJ (1987)

Intravenous boluses of adenosine produced transient epigastric discomfort indistinguishable from spontaneous pain in five of six patients with endoscopically confirmed duodenal ulcer, an effect which was slightly but significantly antagonised by aminophylline. These findings may be relevant to the pathophysiology of peptic ulcer pain.
Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated With Autonomic Blood Pressure Regulation and Hypertension in a Sex-Dependent Fashion
Authors: Yuqing Chen, Fangwen Rao, Juan L. Rodriguez-Flores, Manjula Mahata, Maple M. Fung, Mats Stridsberg, Sucheta M. Vaingankar, Gen Wen, Rany M. Salem, Madhusudan Das, Myles G. Cockburn, Nicholas J. Schork, Michael G. Ziegler, Bruce A. Hamilton, Sushil K. Mahata, Laurent Taupenot, Daniel T. O'Connor
Journal: Journal of the American College of Cardiology (2008)
Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity
Authors: Evaggelia Liaskou, Marika Karikoski, Gary M. Reynolds, Patricia F. Lalor, Chris J. Weston, Nick Pullen, Marko Salmi, Sirpa Jalkanen, David H. Adams
Journal: Hepatology (2010)

Primary sclerosing cholangitis (PSC) and autoimmune hepatitis are hepatic complications associated with inflammatory bowel disease (IBD). The expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) on mucosal endothelium is a prerequisite for the development of IBD, and it is also detected on the hepatic vessels of patients with liver diseases associated with IBD. This aberrant hepatic expression of MAdCAM-1 results in the recruitment of effector cells initially activated in the gut to the liver, in which they drive liver injury. However, the factors responsible for the aberrant hepatic expression of MAdCAM-1 are not known. In this study, we show that deamination of methylamine (MA) by vascular adhesion protein 1 (VAP-1) [a semicarbazide-sensitive amine oxidase (SSAO) expressed in the human liver] in the presence of tumor necrosis factor α induces the expression of functional MAdCAM-1 in hepatic endothelial cells and in intact human liver tissue ex vivo. This is associated with increased adhesion of lymphocytes from patients with PSC to hepatic vessels. Feeding mice MA, a constituent of food and cigarette smoke found in portal blood, led to VAP-1/SSAO–dependent MAdCAM-1 expression in mucosal vessels in vivo. Conclusion: Activation of VAP-1/SSAO enzymatic activity by MA, a constituent of food and cigarette smoke, induces the expression of MAdCAM-1 in hepatic vessels and results in the enhanced recruitment of mucosal effector lymphocytes to the liver. This could be an important mechanism underlying the hepatic complications of IBD. (HEPATOLOGY 2011;53:661-672)
Ligation of the Main Pulmonary Artery and Systemic-Pulmonary Arterial Anastomosis
Authors: EUGENE BRAUNWALD, ANDREW G. MORROW, WILLIAM F. FRIEDMAN
Journal: Circulation (1966)

A new palliative operation is suggested for certain patients with transposition of the great arteries and ventricular septal defect. A systemic-pulmonary artery shunt is created, and the main pulmonary artery ligated. The operation converts transposition of the great arteries to a functional equivalent of truncus arteriosus with normal or nearly normal pulmonary blood flow, a malformation in which the functional derangement of the circulation is not as severe as it is in transposition. The hemodynamic consequences of the procedure were initially evaluated in two patients with pulmonary atresia and transposition, and both improved after shunts were created. The procedure was then carried out in a patient with transposition of the great arteries, ventricular septal defect, mild subpulmonic stenosis, and increased pulmonary blood flow. Postoperatively, the patient has exhibited considerable clinical improvement and significant elevation of arterial oxygen saturation.
Effect of Chromosome Location on Bacterial Mutation Rates
Authors: Richard Ellis Hudson, Ulfar Bergthorsson, John R. Roth, Howard Ochman
Journal: Molecular Biology and Evolution (2002)

In previous comparisons of enterobacterial sequences, synonymous substitution rates were higher in genes closer to the replication terminus, suggesting that mutation rates increase with distance from the replication origin. In order to directly test for the effects of chromosomal location on the rates of point mutations, we assayed the reversion rates of two lacZ alleles inserted at four positions in the Salmonella enterica chromosome. Mutation rates at an intermediate locus were significantly higher than those at loci nearer to and farther from the replication origin. The higher reversion rates at this locus were neither the result of an overall increase in mutation rates produced by the insertion at this location nor a function of the mutations' immediate neighbors, but rather a regional effect. At all loci, regardless of chromosome location, T·A → G·C transversions were more frequent than A·T → G·C transitions during the exponential phase.