tbuckley/cabot-search huggingface dataset:
Setting Health Care Priorities in Oregon-Reply
Authors: David C. Hadorn
Journal: JAMA (1991)

In Reply.  —I thank Drs Gillette and MacLean for their comments.  Neither the Oregon process nor the proposed necessary-care guideline approach excludes costs as a factor to be considered in setting priorities. Cost is the meta-factor, the very raison d'etre , for both processes. If resources were not limited, there would be no need to set priorities in the first place. Moreover, although the ultimate goal in Oregon is to expand access to necessary care, this elusive goal will not be reached unless and until costs are controlled.  Any method for setting health care priorities will succeed in constraining costs, provided that sufficient numbers of low-priority services are identified and removed from coverage under insurance plans. The point of my article is that attempting to identify these low-priority services using cost-effectiveness formulas, or by asking average people how much they would be willing to pay for specified services, will almost certainly
Outcomes after HLA-matched sibling transplantation or chemotherapy in children with acute lymphoblastic leukemia in a second remission after an isolated central nervous system relapse: a collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research
Authors: M Eapen, M-J Zhang, M Devidas, E Raetz, J C Barredo, A K Ritchey, K Godder, S Grupp, V A Lewis, K Malloy, W L Carroll, S M Davies, B M Camitta
Journal: Leukemia (2007)
ABC of one to seven. Health services for children: the community.
Authors: J Wilson
Journal: BMJ (1993)

Primary and secondary care servicesThe health services for children outside the hospital are provided by: * Primary care for all children 0 The primary care service for all children * Secondary care for children with problems 0 The specialist secondary care service for children referred with * Close liaison with social services and problems.educationClose liaison with the local authority social service and education departments is necessary to provide effective
Improper Insulin Compliance May Lead to Hepatomegaly and Elevated Hepatic Enzymes in Type 1 Diabetic Patients: Response to Yu and Howard
Authors: Dario Iafusco, Angela Zanfardino, Lucia D’Alessandro, Francesco Prisco
Journal: Diabetes Care (2004)

We read with interest the recent letter by Yu and Howard (1) describing recurrent episodes of hepatomegaly and pronounced elevation of liver enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) in type 1 diabetic patients with poor metabolic control and treated with high daily doses of insulin (1.3–2.2 units · kg−1 · day−1), considering the extra doses are to correct frequent hyperglycemia and/or diabetic ketoacidosis.

Here we describe similar experiences in our patients affected by autoimmune and nonautoimmune diabetes in the pediatric age range. In particular, …
Origins of the Uricosuric Response
Authors: Thomas H. Steele, Geoffrey Boner
Journal: Journal of Clinical Investigation (1973)

The acute effects of intravenous (i.v.) probenecid and chlorothiazide on renal urate handling were investigated in paired studies in normal men. Uricosuric responses to these agents were compared in the same subjects, both without and with pyrazinamide (PZA) pretreatment. Assuming that PZA selectively inhibits the tubular secretion of urate and that uricosuric agents act by increasing the excretion of filtered urate, then the uricosuric responses (the increment in urate excretion or clearance) should have been unaffected by PZA. Defined in this manner, however, uricosuric responses to probenecid and chlorothiazide were significantly decreased after PZA pretreatment. In order to determine whether PZA diminished other renal actions of chlorothiazide, changes in sodium and inorganic phosphorus excretion were examined. Chlorothiazide produced equivalent natriuretic and phosphaturic responses after PZA pretreatment, indicating that PZA does not interfere with at least some of the renal actions of chlorothiazide. In separate studies, PZA depressed urate excretion by at least 68% during the maintenance of chlorothiazide-induced natriuresis and phosphaturia, suggesting that chlorothiazide does not diminish the anti-secretory action of PZA. The results suggest that probenecid and chlorothiazide may derive their uricosuric properties by facilitating the excretion of both filtered and secreted urate. Possibly, increased excretion of secreted urate might occur through modulation of urate reabsorption at a site distal to tubular secretion, rather than by the direct acceleration of secretory transport. However, PZA-induced interference with the actions of probenecid and chlorothiazide on renal urate transport mechanisms cannot be excluded as a possible explanation for the present results.
Pregnancy Outcome in Type 1 Diabetic Women With Microalbuminuria
Authors: Pia Ekbom, Peter Damm, Bo Feldt-Rasmussen, Ulla Feldt-Rasmussen, Jens Mølvig, Elisabeth R. Mathiesen
Journal: Diabetes Care (2001)

To determine the influence of microalbuminuria on pregnancy outcome in women with type 1 diabetes.This prospective cohort study took place at the Obstetric Clinic at National University Hospital, Copenhagen, from January 1996 to February 2000. All Caucasian women with type 1 diabetes, unselected from the eastern part of Denmark, with a living fetus before 17 weeks of gestation on admission were asked to participate. For women with more than one delivery in the study period, only the first pregnancy was included. Of the remaining 246 women, 240 (98%) entered the study. They were categorized according to their urinary albumin excretion (normal urinary albumin excretion, <30 mg/24 h; microalbuminuria, 30-300 mg/24 h; or diabetic nephropathy, >300 mg/24 h) before pregnancy or in the first trimester.A total of 203 women (85%) had normal urinary albumin excretion, 26 (11%) had microalbuminuria, and 11 (5%) had diabetic nephropathy. Mean HbA(1c) at 2-6 weeks was 7.5% (SD 1.1), 8.1 (0.9), and 8.8 (1.3) (P < 0.001), respectively. Of all deliveries in women with normal urinary albumin excretion, microalbuminuria, and diabetic nephropathy, 35, 62, and 91% (P < 0.001), respectively, were preterm, and 2, 4, and 45% (P < 0.001), respectively, were small-for-gestational-age infants. Preeclampsia developed in 6, 42, and 64% of the women (P < 0.001), respectively. Category of urinary albumin excretion (P < 0.01) and HbA(1c) at 2-6 weeks (P < 0.05) were independently associated with preterm delivery.The prevalence of preterm delivery is considerably increased in women with microalbuminuria, mainly caused by preeclampsia. Classification according to urinary albumin excretion and metabolic control around the time of conception are superior to the White classification in predicting preterm delivery in women with type 1 diabetes.
Methylmercury and Neurodevelopment: Reanalysis of the Seychelles Child Development Study Outcomes at 66 Months of Age
Authors: Philip W. Davidson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An exaggerated erythema response to a cold pressure test in patients with cold urticaria
Authors: J.S. PASRICHA, K.C. NAYYAR
Journal: British Journal of Dermatology (1973)

Journal Article An exaggerated erythema response to a cold pressure test in patients with cold urticaria Get access J.S. PASRICHA, J.S. PASRICHA Department of Dermatology and Venereology, All India Institure of Medical Sciences, New Delhi‐16, India Search for other works by this author on: Oxford Academic Google Scholar K.C. NAYYAR K.C. NAYYAR Department of Dermatology and Venereology, All India Institure of Medical Sciences, New Delhi‐16, India Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 89, Issue 6, 1 December 1973, Pages 587–593, https://doi.org/10.1111/j.1365-2133.1973.tb07583.x Published: 01 December 1973 Article history Accepted: 08 May 1973 Published: 01 December 1973
Estimation of the Biliary Excretion of Different Cephalosporins Utilizing Retrograde Cholangio-Pancreatography (ERCP)
Authors: E.E. Ohnhaus, F. Halter, G. Lebek
Journal: Endoscopy (1981)

In the present study 21 patients undergoing retrograde cholangio-pancreatography (ERCP) were given cefamandole, cefazolin or cefaclor, and plasma and bile concentrations were measured. The cannulation of the common bile duct was possible in most of the patients investigated, but no bile could be obtained in 7 of them. In the patients in whom bile was obtained, concentrations comparable to other studies were estimated, despite a wide variation in the individual patients. In addition, cefaclor, which is not known to be excreted in the bile, showed sufficiently high inhibitory bile concentrations. Using ERCP for the estimation of bile concentrations of different drugs useful information can be obtained about the excretion of certain substances. However, for sophisticated pharmacokinetic studies, the method has certain limitations as compared with classical T-tube sampling.
ACQUIRED LINEAR NAEVUS SHOWING HISTOLOGICAL FEATURES OF KERATOSIS FOLLICULARIS
Authors: J. A. L. LEEMING
Journal: British Journal of Dermatology (1969)

SUMMARY.— The case is reported of a linear and zosteriform warty naevus of 3 years' duration in a woman aged 30. Biopsy showed the histological features of keratosis follicularis. The relationship between circumscribed dyskeratotic lesions and Darier's disease is discussed.
Dietary Iron Overload and Induced Lipid Peroxidation Are Associated With Impaired Plasma Lipid Transport and Hepatic Sterol Metabolism in Rats
Authors: Sylvain Brunet, Louise Thibault, Edgard Delvin, Wagner Yotov, Moïse Bendayan, Emile Levy
Journal: Hepatology (1999)

Although hemochromatosis is characterized by dramatic morphological and functional alterations in the liver, little is known about the effects of an excess of iron on lipid metabolism. Therefore, we determined the effect of chronic iron overload on plasma lipid profile and lipoprotein composition, as well as on hepatic cholesterol metabolism and biliary sterol output. Rats administered a diet enriched with 3% iron carbonyl for 12 weeks displayed a 30–fold increase in iron ( P &lt; .0001) and a 5–fold rise in malondialdehyde ( P &lt; .001) in the liver. When compared with pair–fed controls, iron–overload rats showed a significant increase in triglycerides ( P &lt; .005), free cholesterol ( P &lt; .006), cholesteryl ester ( P &lt; .007), and high–density lipoprotein (HDL)–cholesterol ( P &lt; .003). Triglyceride and cholesteryl ester enrichment, protein depletion, size increase, and apolipoprotein composition alterations characterized the very low density lipoprotein (VLDL) and HDL particles of iron–overload rats. Assessment of the activity of intracellular key enzymes for cholesterol homeostasis in these rats disclosed a reduction in 3–hydroxy–3–methylglutaryl coenzyme A (HMG–CoA) reductase (66%, P &lt; .005) and cholesterol 7α–hydroxylase (58%, P &lt; .0004) with an increment of acyl–CoA: cholesterol acyltransferase (62%, P &lt; .002). The lack of optimal enzymatic activity may be a result of marked membrane lipid peroxidation that brings about fluidity drop ( P &lt; .029) in microsomes of iron–overload rats (5.00 ± 0.013) versus controls (8.20 ± 0.03), reflected by polarization. A decline of the pool size of cholesterol and bile acids was noted in iron–overload rats during a 6–hour bile drainage. Our results show that experimental iron overload causes marked perturbations in plasma lipid transport and hepatobiliary sterol metabolism. Given the positive correlation of malondialdehyde with most of the altered parameters, iron–catalyzed lipid peroxidation may well be one of the involved mechanisms.
RISK FACTORS FOR LONG TERM-OUTOMES IN BALLOON VALVULOPLASTY FOR AORTIC STENOSIS
Authors: Shiraz Maskatia, Frank F. Ing, Henri Justino, Matthew A. Crystal, Charles E. Mullins, Raphael J. Mattamal, E. O’Brian Smith, Christopher J. Petit
Journal: Journal of the American College of Cardiology (2010)
Cardiovascular mass and ventricular function after celiprolol in Wistar-Kyoto and spontaneously hypertensive rats
Authors: S. Horinaka, E. D Frohlich
Journal: Cardiovascular Research (1992)

The effects of a new beta 1 adrenergic receptor blocking agent with beta 2 receptor agonistic properties on cardiovascular mass, left ventricular function, and aortic distensibility were studied in Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats.20 male SHR and 20 male WKY rats (10 treated and 10 untreated) aged 22 weeks were studied after three weeks of treatment. Cardiovascular mass was measured and left ventricular function was assessed using electromagnetic flowmetry while rapidly infusing whole blood at pharmacologically reduced mean arterial pressure and at pretreatment arterial pressure levels. Aortic distensibility was assessed by obtaining pressure-volume relationships in isolated aortic segments.Mean arterial pressure was reduced without changing cardiac output in SHR (p less than 0.01); it remained unchanged in WKY despite reduced cardiac output. Most noteworthy, and like no other agent studied to date, celiprolol significantly reduced both left and right ventricular as well as aortic mass in both WKY and SHR. Despite these similar mass reductions, celiprolol improved left ventricular function (p less than 0.01) and aortic distensibility (p less than 0.05) only in the SHR, a function maintained even when mean arterial pressure was increased abruptly to pretreatment levels.Unlike other beta receptor blockers (or any other agent studied in the SHR), celiprolol was effective in reducing mass of right and left ventricles and of aorta; decreasing mean arterial pressure through a fall in total peripheral resistance; and improving left ventricular function and aortic distensibility in the SHR. In contrast, while these structural changes were also produced in WKY, they were not associated with similar functional responses. These findings provide further support for the thesis of a structural and haemodynamic dissociation in antihypertensive therapy.
Prenatal Screening for Hepatitis B Antigen-Reply
Authors: Mark A. Kane
Journal: JAMA (1989)

<h3>In Reply.—</h3> Dr Ross questions two issues discussed in the ACIP<sup>1</sup>recommendations for routine HBsAg screening of pregnant women: the scientific justification that treatment for infants born to hepatitis B virus carrier mothers be initiated within 24 hours of birth and the feasibility of obtaining HBsAg test results within 24 hours for women who come to the hospital to deliver without prior HBsAg screening. The scientific basis of the need for rapid treatment of exposed infants stems from early studies of the efficacy of hepatitis B immune globulin (HBIG) in the prevention of perinatal hepatitis B virus transmission. One study showed that a single dose of HBIG had a 50% efficacy if given within the first 48 hours of life but had no efficacy if given later.<sup>2</sup>On the basis of this information, in all subsequent studies of HBIG and hepatitis vaccine researchers administered the HBIG as soon
Lost in transition? Between paediatric and adult services
Authors: Janet E McDonagh, Russell M Viner
Journal: BMJ (2006)

It's time to improve the transition of adolescents from paediatric to adult services 

P reventing adolescents becoming lost in the transfer between paediatric and adult health services is a major challenge for healthcare providers, paediatric and adult alike. Until recently British health services have largely ignored adolescents.1 But as increasing numbers of young people are surviving into adulthood with illnesses they developed in childhood, the need for transitional care appropriate to their age and development is becoming more obvious and acute.2 Adolescence is also a time when adult behaviours become established and therefore represents a window of opportunity to promote healthy behaviour and influence the public health burden of tomorrow's adults.1

Transitional care is a multidimensional, multidisciplinary process that addresses not only the medical needs of adolescents as they move from children's services to adult services but also their psychosocial, educational, and vocational needs. The need for such services has been shown by many surveys of young people with various chronic conditions and their care givers,3–6 and is supported by policy documents in the United Kingdom and United States.2–9 To date, however, there …
The Duke Longitudinal Studies of Normal Aging 1955-1980: Overview of History, Design, and Findings
Authors: Isadore Rossman
Journal: JAMA (1986)

This slim volume is essentially an overview and a partial summary of the quarter-century history of the Duke Longitudinal Project. With the working goal of delineating normative aging changes and being broadly conceived to be multidisciplinary in the data collection, the Duke experience also records some of the difficulties and hazards that longitudinal studies encounter. The investigator is hampered by the following: losing subjects to follow-up (the missing data problem); the emergence of better methods, which render older data obsolete; and the increasing difficulties of interviewing frail homebound or institution-bound subjects. Although the focus of interest was on the cognitive, psychiatric, and social aspects of aging, these could not, of course, be isolated from the medical and pathologic. Although the size of the study—270 subjects for the First and 502 for the Second Longitudinal Study—was doubtless sufficient for the first set of objectives, it was not adequate for other epidemiologic
Prevention of Virus Diseases in the Community
Authors: G. W. A. Dick
Journal: BMJ (1962)

Post-vaccinial encephalitis 22-4 11-0 26-5 5 3 Others.?2-7 ?0 Total | 18-4 5-3adult life-a highly significant difference.The presumed diminution of risk to an individual vaccinated in infancy and revaccinated as an adult-which was one of the pillars on which our policy was founded-can be seen to be fallacious.It is also often said that infant on 16 July
(10) Morphoea arising in a hypoplastic breast
Authors: David Goldin, R.H. Champion
Journal: British Journal of Dermatology (1975)

Journal Article (10) Morphoea arising in a hypoplastic breast Get access David Goldin, David Goldin Addenbrooke's Hospital, Cambridge Search for other works by this author on: Oxford Academic Google Scholar R.H. Champion R.H. Champion Addenbrooke's Hospital, Cambridge Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 93, Issue s11, 1 July 1975, Pages 44–45, https://doi.org/10.1111/j.1365-2133.1975.tb06792.x Published: 01 July 1975
Appropriateness of hospital referral for hypertension.
Authors: S Juncosa, R B Jones, S M McGhee
Journal: BMJ (1990)

OBJECTIVE--To examine the efficiency of referral to an outpatient clinic and particularly the differences between referrals from general practitioners practising in health centres and those from other general practitioners. DESIGN--Retrospective audit of referral letters and case notes by comparison with externally set standards of appropriateness of referrals over two years. SETTING--Outpatient hypertension clinic at Western Infirmary, Glasgow. PATIENTS--306 Consecutive new referrals of patients over two years (1 May 1986 to 30 April 1988), for whom case notes were available in 298. MAIN OUTCOME MEASURES--Congruence of referrals with each of two standards of appropriateness based on published opinion on specialist referral (standard 1 was stricter than standard 2) and completeness of referral letters. RESULTS--Of the 298 referrals, those from general practitioners accounted for 205, from other hospital departments 68, and from other sources 25. Overall, 84 referrals of the 205 from general practice met the first standard and 134 met the second, more lenient standard. 58 Referral letters from outside the hospital had some item missing. Referrals from general practitioners working in health centres (a fifth of the total) were significantly more likely to meet both standards (p less than 0.01) and to send a complete referral letter (p less than 0.001) than the 145 referred by other general practitioners. CONCLUSIONS--According to the standards used, general practitioners in health centres made more appropriate referrals, and further investigation is needed to identify the underlying factors responsible.
High titres of serum antinuclear antibodies, mostly directed against nucleolar antigens, are associated with the presence of coronary atherosclerosis
Authors: D J Grainger
Journal: Annals of the Rheumatic Diseases (2002)

Inappropriate inflammation is a key mechanism in the development of atherosclerosis. Antibodies against components of the atherosclerotic lesion, in particular, oxidised low density lipoprotein, have been described.To determine whether a systemic autoimmune response, characterised by the presence of high titres of antinuclear antibodies, is associated with the presence of coronary atherosclerosis.Serum was prepared from 40 subjects (aged 53-76) with at least 50% stenoses of three main coronary arteries (TVD subjects), and 30 subjects (aged 48-74) with no evidence of coronary atherosclerosis (NCA subjects) determined by coronary angiography.Antinuclear antibodies (ANA), characterised by immunofluorescent detection of human antibodies bound to HEp-2000 cells, were detected at a titre of at least 1/40 in 28 (70%) of the TVD subjects, but only five (17%) of the NCA patients (odds ratio 11.67 (95% confidence interval (CI) 3.91 to 17.82; p<0.001)). Most ANA positive TVD subjects had a pattern typical of antibodies directed against nucleolar antigens. The antigen has not yet been identified, but several common extractable antigens were excluded. The presence of ANA was not associated with incidence of prior myocardial infarction among the TVD group.The presence of ANA, commonly associated with autoimmune diseases, is substantially more prevalent among subjects with severe coronary atherosclerosis than those with normal coronary arteries. This association merits further assessment as a potentially useful indicator of increased risk of coronary heart disease.
Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412
Authors: Karl J. Aichberger, Matthias Mayerhofer, Karoline V. Gleixner, Maria-Theresa Krauth, Alexander Gruze, Winfried F. Pickl, Volker Wacheck, Edgar Selzer, Leonhard Müllauer, Hermine Agis, Christian Sillaber, Peter Valent
Journal: Blood (2006)