tbuckley/cabot-search huggingface dataset:
A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease
Authors: Irina A. Sergeeva, Ingeborg B. Hooijkaas, Ingeborg Van Der Made, Willeke M.C. Jong, Esther E. Creemers, Vincent M. Christoffels
Journal: Cardiovascular Research (2013)

AimThe expression of Nppa (ANF) and Nppb (BNP) marks the chamber myocardium in the embryo, and both genes serve as early and accurate markers for hypertrophy and heart failure. Non-invasive visualization of Nppa–Nppb expression in living mice would enable to evaluate the disease state during the course of time in heart disease models. We sought to develop a method to assess the pattern and level of Nppa and Nppb expression within living mice.
Respiratory Dysrhythmias during Sleep
Authors: Howard L. Bleich, Mary Jean Moore, Neil S. Cherniack
Journal: New England Journal of Medicine (1981)

NORMALLY, breathing by an undisturbed, awake person involves a smooth and regularly recurring sequence of inspiration and expiration without pauses. The rate and depth of breathing are regulated by a negative-feedback control system to maintain arterial partial pressures of carbon dioxide (PCO2) and oxygen (PO2) at relatively constant levels. Diseases of the lung or chest wall may produce hypoxemia and may raise or lower arterial PCO2, but they seldom affect the regularity of breathing. On the other hand, striking changes in the rhythm of breathing occur in disorders that severely disrupt the functioning of . . .
A SIMPLE, INEXPENSIVE AND EFFICIENT EXTENSION APPARATUS FOR TREATING FRACTURES OF THE TIBIA AND FIBULA
Authors: E. M. Stanton
Journal: JAMA (1923)

The principle of a screw-controlled extension apparatus rigidly attached to a divided plaster cast has long been used by a number of surgeons in the treatment of certain simple and compound fractures of both bones of the leg. The screw-extension apparatus so far described has been of a rigidly built type, often quite expensive and procurable only through instrument makers. This type of apparatus is usually not available when needed; and, when it is available, often the mechanical perfection of its construction tends to make it too rigid to be readily adapted to the exigencies of individual cases. The screw extension apparatus employed by me is so constructed that it can be readily fitted to any cast at any point from the ankle to the knee, and can be altered at will to meet any special requirements of individual cases. Figure 1 illustrates the general construction of the extension units.
The significance of Leu 8 negative T cells in lymphoid skin infiltrates: malignant transformation, selective homing or T-cell activation?
Authors: J.U. RIJLAARSDAM, D.M. BOORSMA, P. HAAN, S. SAMPAT, R. WILLEMZE
Journal: British Journal of Dermatology (1990)

The expression of Leu 8 was studied on skin biopsies from a large group of patients with benign and malignant skin disorders and correlated with the expression of T-cell differentiation antigens and activation markers. The effect of in vitro stimulation of peripheral blood T cells and T-cell subsets on the expression of Leu 8 antigen was also determined. In all the skin diseases studied an inverse relationship was found between the proportions of cells expressing Leu 8 and HLA-DR. A deficiency of Leu 8 positive cells was not specific for mycosis fungoides, but was also found in several reactive dermatoses. Stimulation of peripheral blood cells with phytohaemagglutinin (PHA), concanavalin A (Con A), and anti-CD3-PMA resulted in a considerable decrease of Leu 8 antigen expression on day 3 in both CD4+ and CD8+ T cells. These data suggest that the low proportion of Leu 8+ T cells in mycosis fungoides and several reactive skin disorders is not related to malignant transformation or selective homing of Leu 8- T cells, but probably results from local T-cell activation.
Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma
Authors: Sunitha Kakarla, Kevin KH Chow, Melinda Mata, Donald R Shaffer, Xiao-Tong Song, Meng-Fen Wu, Hao Liu, Lisa L Wang, David R Rowley, Klaus Pfizenmaier, Stephen Gottschalk
Journal: Molecular Therapy (2013)

Cancer-associated fibroblasts (CAFs), the principle component of the tumor-associated stroma, form a highly protumorigenic and immunosuppressive microenvironment that mediates therapeutic resistance. Co-targeting CAFs in addition to cancer cells may therefore augment the antitumor response. Fibroblast activation protein-α (FAP), a type 2 dipeptidyl peptidase, is expressed on CAFs in a majority of solid tumors making it an attractive immunotherapeutic target. To target FAP-positive CAFs in the tumor-associated stroma, we genetically modified T cells to express a FAP-specific chimeric antigen receptor (CAR). The resulting FAP-specific T cells recognized and killed FAP-positive target cells as determined by proinflammatory cytokine release and target cell lysis. In an established A549 lung cancer model, adoptive transfer of FAP-specific T cells significantly reduced FAP-positive stromal cells, with a concomitant decrease in tumor growth. Combining these FAP-specific T cells with T cells that targeted the EphA2 antigen on the A549 cancer cells themselves significantly enhanced overall antitumor activity and conferred a survival advantage compared to either alone. Our study underscores the value of co-targeting both CAFs and cancer cells to increase the benefits of T-cell immunotherapy for solid tumors.
Eosinophilia With <i>FIP1L1-PDGFRA</i> Fusion in a Patient With Chronic Myelomonocytic Leukemia
Authors: Victor Zota, Patricia M. Miron, Bruce A. Woda, Azra Raza, Sa A. Wang
Journal: Journal of Clinical Oncology (2008)

Eosinophilia With FIP1L1-PDGFRA Fusion in a Patient With Chronic Myelomonocytic LeukemiaA 67-year-old woman with a past medical history of alfathalassemia trait was referred to our medical center for evaluation of anemia, thrombocytopenia, and leukocytosis.CBC on admission revealed a WBC of 55.5 ϫ 10 9 /L, platelets 81 ϫ 10 9 /L, and hemoglobin 11.3 g/dL.The differential showed 86% neutrophils, 6% monocytes, 0.1% eosinophils, 0% basophils, 8% lymphocytes with 1% circulating blasts, and dysplastic granulocytes noted on the blood film.An enlarged spleen was discovered on physical examination, and confirmed by a computed tomography scan.The initial bone marrow (BM) examination revealed 95% cellularity with trilineage dysplasia.The BM aspirate smears showed 3% blasts, 4% monocytes, and less than 1% eosinophils.Study of 20 giemsa-trypsin-giemsabanded metaphase cells showed a normal female karyotype.The patient was diagnosed with myelodysplastic/myeloproliferative disease, with clinicopathologic features of atypical chronic myeloid leukemia and chronic myelomonocytic leukemia 1 (CMML-1).She was started on an experimental trial with combined thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid.Two months later, her peripheral monocyte proportion increased and exceeded 10%, with absolute monocytosis (up to 52.6 ϫ 10 9 /L).Her diagnosis met the criteria for CMML-1.Four months after the initial BM biopsy, she developed peripheral eosinophilia, with an absolute eosinophil count ranging from 1.5 to 4.2 ϫ10 9 /L.Her peripheral eosinophilia persisted for a period of 2 to 3 months under a close follow-up.BM biopsy now revealed a 100% cellularity with large clusters/small sheets of eosinophils (Fig 1A).The BM aspirate showed 4% blasts, 5% monocytes, and 10% eosinophils, including many eosinophilic precursors (Fig 1B).Conventional G-banding again showed a normal female karyotype.Fluorescent in situ hybridization (FISH) with a probe set containing FIP1L1 (green), CHIC2 (red) and PDGFRA (green) loci (MP Biomedicals, Solon, OH) was performed on interphase nuclei, and a hybridization pattern consistent with deletion of CHIC2 and fusion of FIP1L1-PDGFRA was observed in 16 of 100 nuclei.Figure 2 shows three nuclei containing abnormal fusion signals (arrows), with deletion of CHIC2 and a resultant FIP1L-PDGFRA (green/green) fusion.The patient was started on imatinib 400 mg orally daily, with a rapid resolution of her peripheral eosinophilia.However, her other hematologic indices showed no improvement.Imatinib was discontinued after 6 weeks.A repeated BM biopsy showed a 100% cellular marrow with only occasional eosinophils (Fig 1C).The BM aspirate revealed
84 IMPROVEMENT OF INTESTINAL PERMEABILITY AND REDUCING BACTERIAL TRANSLOCATION BY BETABLOCKER TREATMENT IS ASSOCIATED WITH A LOWER RISK OF VARICEAL BLEEDING
Authors: T. Reiberger, A. Ferlitsch, B.A. Payer, M. Mandorfer, B.B. Heinisch, H. Hayden, M. Trauner, M. Peck-Radosavljevic
Journal: Journal of Hepatology (2013)
State of the Art of Micro‐CT Applications in Dental Research
Authors: Michael V Swain, Jing Xue
Journal: International Journal of Oral Science (2009)

This review highlights the recent advances in X‐ray microcomputed tomography (Micro‐CT) applied in dental research. It summarizes Micro‐CT applications in measurement of enamel thickness, root canal morphology, evaluation of root canal preparation, craniofacial skeletal structure, micro finite element modeling, dental tissue engineering, mineral density of dental hard tissues and about dental implants. Details of studies in each of these areas are highlighted along with the advantages of Micro‐CT, and finally a summary of the future applications of Micro‐CT in dental research is given.
Hepatitis C virus infection and nodular prurigo
Authors: T. Yamamoto, A. Yokoyama
Journal: British Journal of Dermatology (1996)

Journal Article Hepatitis C virus infection and nodular prurigo Get access T. Yamamoto, T. Yamamoto Department of Dermatology, Tsuchiura Kyodo General Hospital, 11‐7, Manabe‐shinmachi, Tsuchiura‐city, Ibaraki, Japan. Search for other works by this author on: Oxford Academic Google Scholar A. Yokoyama A. Yokoyama Department of Dermatology, Tsuchiura Kyodo General Hospital, 11‐7, Manabe‐shinmachi, Tsuchiura‐city, Ibaraki, Japan. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 3, 1 September 1996, Page 499, https://doi.org/10.1111/j.1365-2133.1996.tb01535.x Published: 01 September 1996
Abstract 1082: IL27 promotes papilloma formation via inducing a pro-inflammatory milieu in the skin
Authors: Denada Dibra, Xueqing Xia, Melissa Newman, Camille Keenan, Shulin Li
Journal: Cancer Research (2014)

Abstract Ras activation plays an important role in Squamous Cell Carcinomas (SCC) development. Additionally, there is large evidence confirming the role of inflammation during cancer initiation. However, the interaction between inflammation and oncogene activation is poorly understood in tumorigenesis. We found that IL27 promotes papilloma formation in a 2 step skin carcinogenesis (DMBA followed by benzoyl peroxide) model where DMBA causes Ras mutation. Because K15-positive follicular stem cells contribute to papillomas in the two-step skin carcinogenesis model, we used an inducible oncogenic K-RasG12D under the K15 promoter, which marks follicular stem cells. Indeed, treating mice with IL27 increased papilloma incidence earlier in these K15-K-RASG12D mice. Mechanistically, we see that ETAR+ macrophages are significantly increased in IL27-treated K15-K-RasG12D mice. Additionally, the ETAR ligand ET1, and the downstream factor of ETAR, COX2, are upregulated in these K15-KRasG12D mice by IL27, suggesting that ET1/ETAR pathway is involved in IL27 mediated papilloma formation. Indeed, IL27-mediated papilloma formation was reversed by using the ETAR inhibitor ZD4054. Therefore, the data shown here suggest that IL27 drives accumulation of ETAR+ macrophages, ET1, and Cox-2 in the skin and ultimately causes faster papilloma formation in K-Ras mutated follicular stem cells. These findings propose an unrecognized role of IL27 during initiation of skin carcinogenesis. Citation Format: Denada Dibra, Xueqing Xia, Melissa Newman, Camille Keenan, Shulin Li. IL27 promotes papilloma formation via inducing a pro-inflammatory milieu in the skin. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1082. doi:10.1158/1538-7445.AM2014-1082
Clinical Crossroads: A 21-Year-Old Woman With Menstrual Irregularity-Reply
Authors: Ann J. Davis
Journal: JAMA (1997)

In Reply.  —I completely agree with Dr Fogarty that menstruation is a normal physiologic function and should be viewed as such. A video of Ms K, the patient, describing her problem was played prior to the discussion of the case. Ms K stated that her irregular cycles caused her to be anxious and were a source of aggravation. These terms were direct quotations from the patient.  While menstruation is a normal physiologic process, irregular menstruation may reflect abnormality. Abnormal menstrual cycling can and does cause anxiety in some patients.  Regarding Dr Littell's concerns, anticipatory patient counseling with regard to contraceptive adverse effects or menstrual changes is too often overlooked in family planning visits. In my view, it is critical to counsel patients regarding expected menstrual changes with depomedroxyprogesterone. In terms of the other potential adverse effects of depomedroxyprogesterone that Littell mentions (depression, weight gain, and osteoporosis), these are poorly documented or undocumented
Use of U-500 Regular Insulin in Type 2 Diabetes
Authors: Wafic S. Wafa, Mukhtar I. Khan
Journal: Diabetes Care (2006)

In a recent report in Diabetes Care , experience using U-500 regular insulin (U-500) in syndromic forms of insulin resistance was described (1). Due to its higher concentration, U-500 has pharmacokinetics that are believed to be similar to U-100 NPH insulin peaking later and lasting longer than U-100 regular insulin. These authors suggest that U-500 may be used in type 2 diabetic patients with severe insulin resistance who fail usual treatment (1). We report our experience using U-500 insulin in type 2 …
Low blood pressure, low mood?
Authors: J. A. Pilgrim, S. Stansfeld, M. Marmot
Journal: BMJ (1992)

OBJECTIVE--To determine whether a set of physical symptoms is associated with low blood pressure and to investigate the possible role of psychological factors in their occurrence. DESIGN--Analysis of data collected by questionnaire and physical screening from the first phase of the Whitehall II study, a cohort study of an employed population. SETTING--23 civil service departments in London. SUBJECTS--10,314 male and female London based civil servants aged between 35 and 55. MAIN OUTCOME MEASURES--Symptoms of dizziness-giddiness and unexplained tiredness; psychological functioning as measured by the 30 item general health questionnaire in which the response "no more than usual" to an item about disease was scored as indicating chronic illness. RESULTS--Dizziness-giddiness in men and unexplained tiredness in both men and women were significantly related to low systolic blood pressure. There was a highly significant inverse relation between general health questionnaire score and systolic blood pressure for both men and women, which persisted after controlling for potentially confounding variables, including age, body mass index, drug treatment, physical illness, and exercise. This association of low blood pressure with physical symptoms was no longer significant when general health questionnaire score was controlled for. CONCLUSIONS--There seems a strong relation between low systolic blood pressure and minor psychological dysfunction. Associated physical symptoms seem to be secondary to the primary disturbance in mental state.
Love Poem to Amelio Sanchez
Authors: Phillip J. Cozzi
Journal: Annals of Internal Medicine (1991)

Ad Libitum1 May 1991Love Poem to Amelio SanchezPhillip J. Cozzi, MDPhillip J. Cozzi, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-9-834_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI love you Mr. Sanchez for your beardhides animals that leave filth.I love you for your eyes,clear and green, are beautiful.Your glasses, missing an earpiece,ride at an angle on your nose.I love you for the stink that greets meat the length of your arm in handshake.I love you for your noncompliance,most clever and ignorant.The eviction papers, the sores on your backbreed in me affection and contempt.You are my utility.You turn me from introspectionand focus my eyes, blank and brown,on the twisting canyon of needthat... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 9219 Shields Brookfield, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1991Volume 114, Issue 9Page: 834-834 ePublished: 1 December 2008 Issue Published: 1 May 1991 PDF downloadLoading ...
Reversal of human allergen-specific CRTH2+ TH2 cells by IL-12 or the PS-DSP30 oligodeoxynucleotide
Authors: Francesco Annunziato, Lorenzo Cosmi, Roberto Manetti, Francesca Brugnolo, Paola Parronchi, Enrico Maggi, Kinya Nagata, Sergio Romagnani
Journal: Journal of Allergy and Clinical Immunology (2001)
Prevalence and risk factors of bacteriuria in cirrhotic patients: a prospective case-control multicenter study in 244 patients
Authors: Jean-François Cadranel, Jacques Denis, Arnaud Pauwels, Jean-Claude Barbare, Claude Eugène, Vincent di Martino, Etienne Poquet, Abdel Medini, Pierre Coutarel, Jean-Paul Latrive, Patrice Lemaître, Bruno Devergie
Journal: Journal of Hepatology (1999)
Lack of PTEN sequesters CHK1 and initiates genetic instability
Authors: Janusz Puc, Megan Keniry, Hong Shen Li, Tej K. Pandita, Atish D. Choudhury, Lorenzo Memeo, Mahesh Mansukhani, Vundavalli V.V.S. Murty, Zbigniew Gaciong, Sarah E.M. Meek, Helen Piwnica-Worms, Hanina Hibshoosh, Ramon Parsons
Journal: Cancer Cell (2005)
RETROVERSION OF THE UTERUS.A CLINICAL STUDY OF THE COMPLICATIONS, SYMPTOMS AND TREATMENT.
Authors: L. H. DUNNING
Journal: JAMA (1903)

The writer has found 112 recorded cases of retroversion of the uterus examined by him in his office practice from June 10, 1900, to Jan. 9, 1903. An accurate and fairly comprehensive record of these cases has been kept in his case book. Such essential points as were omitted in the original entry have been looked up and duly entered. A clinical study of these records was begun with the hope that the findings might be helpful in furnishing the writer with some positive indications for treatment of future cases. He has found the study profitable and herewith submits his findings, together with such remarks and conclusions as present themselves to him. Unfortunately, forty-three of the 112 cases whose histories are recorded were seen by the writer but once or twice, so he can say nothing regarding their subsequent course. Fifty-six cases in all were treated by the writer.
Repair of retrograde aortic dissection
Authors: D. Bregman
Journal: JAMA (1976)

To the Editor.—  The recent article by Bilgutay et al (236:465, 1976) describes the technique of using a Teflon tube or patch as part of the repair of the so-called type IV or retrograde aortic dissection occurring with femoral perfusion during cardiopulmonary bypass. Since most of us are now routinely using aortic perfusion, fortunately this complication is becoming very rare.  Of particular note is the method described by the authors to construct a coronary artery-saphenous vein bypass graft in this unusual situation by employing the subclavian to coronary artery route. We would like to call attention to a simpler approach described by Cooley et al, 1 in which the proximal anastomosis is constructed directly from the Teflon or Dacron tube. This technique can also be employed in any aortic root reconstructive procedure where it is necessary either to reimplant the coronary ostia or to revascularize the heart. 2
Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2 terminus.
Authors: L A Frohman, T R Downs, T C Williams, E P Heimer, Y C Pan, A M Felix
Journal: Journal of Clinical Investigation (1986)

The effect of plasma on degradation of human growth hormone-releasing hormone (GRH) was examined in vitro and in vivo using high performance liquid chromatography (HPLC), radioimmunoassay (RIA), and bioassay. When GRH(1-44)-NH2 was incubated with human plasma, the t1/2 of total GRH immunoreactivity was 63 min (RIA). However, HPLC revealed a more rapid disappearance (t1/2, 17 min) of GRH(1-44)-NH2 that was associated with the appearance of a less hydrophobic but relatively stable peptide that was fully immunoreactive. Sequence analysis indicated its structure to be GRH(3-44)-NH2. Identity was also confirmed by co-elution of purified and synthetic peptides on HPLC. Biologic activity of GRH(3-44)-NH2 was less than 10(-3) that of GRH(1-44)-NH2. After intravenous injection of GRH(1-44)-NH2 in normal subjects, a plasma immunoreactive peak with HPLC retention comparable to GRH(3-44)-NH2 was detected within 1 min and the t1/2 of GRH(1-44)-NH2 (HPLC) was 6.8 min. The results provide evidence for GRH inactivation by a plasma dipeptidylaminopeptidase that could limit its effect on the pituitary.
Health department consults on automatic substitution of generics
Authors: S. Mayor
Journal: BMJ (2010)

England’s Department of Health has launched a consultation on proposals for automatic generic substitution, in which pharmacists could dispense generic forms of drugs instead of branded versions even if the prescribing doctor or nurse has written a prescription for a brand.

The consultation report outlines three options. The first is to keep the current arrangements, in which pharmacists are required to dispense exactly what is written on a prescription and cannot substitute a generic version for a brand name drug without prior agreement with the prescriber. The second would allow substitution of generic equivalents but would specify a list of exempt products. The third option, preferred by the health department, would allow generic substitution of a specified group of products.

Under the third option all prescriptions would be dispensed as written except for …
Cesarean delivery is associated with celiac disease but not inflammatory bowel disease in children
Authors: Evalotte Decker, Mathias Hornef, Silvia Stockinger
Journal: Gut Microbes (2011)

The postnatal period represents a particularly dynamic phase in the establishment of the host-microbial homeostasis. The sterile protected intestinal mucosa of the fetus becomes exposed to and subsequently colonized by a complex and diverse bacterial community. Both, the exposure to microbial ligands and the bacterial colonization have been described to differ between neonates born vaginally or by cesarean delivery. These differences might influence the development of the mucosal immune system, the establishment of a stable intestinal host-microbial homeostasis, and ultimately contribute to the risk to acquire immune mediated diseases later in life. Indeed, an increased risk for atopic diseases such as allergic rhinitis and asthma was reported in children born by cesarean delivery. Our recent study described an association between cesarean delivery and celiac disease. Here we summarize the available information on postnatal microbial colonization and the influence of the mode of delivery on flora composition and host microbial homeostasis. We discuss possible consequences of the mode of delivery on epithelial barrier function and the establishment of the mucosal immune system and speculate on functional links between flora alterations and the development of inappropriate host immune responses that may contribute to enteric inflammatory diseases.
INCIDENCE OF TYPE 5 MYOCARDIAL INFARCTION BY THE THIRD UNIVERSAL DEFINITION
Authors: Shirjel Alam, Nick Spath, Marc Dweck, Anoop Shah, Scott Semple, Graham Mckillop, Saeed Mirsadraee, Renzo Pessotto, Vipin Zamvar, Nicholas Mills, David Newby, Peter Henriksen
Journal: Journal of the American College of Cardiology (2013)