Rejuvenation in Older Adults Receiving Oral Ghrelin
Authors: Markus Gaugg
Journal: Annals of Internal Medicine (2009)

Letters5 May 2009Rejuvenation in Older Adults Receiving Oral GhrelinMarkus Gaugg, MDMarkus Gaugg, MDFrom Kaiser Franz Josef Hospital, 1100 Vienna, Austria.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-9-200905050-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the study by Nass and colleagues (1). I would like to address some critical issues, with particular reference to adverse events.First, growing evidence suggests that IGF-I is a cytokine involved in promotion and induction of oncogenesis in different types of tumors, such as Ewing sarcoma (2), renal cell carcinoma (3), and adenocarcinoma of the gastrointestinal tract (for example, colorectal carcinoma [4] and cholangiocellular carcinoma). Why didn't the authors report the results of screening methods (fecal occult blood test, abdominal ultrasonography, colonoscopy) or staging of reported adverse events?Second, magnetic resonance imaging and ...References1. Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE, Clasey JL, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149:601-11. [PMID: 18981485] LinkGoogle Scholar2. Cironi L, Riggi N, Provero P, Wolf N, Suvà ML, Suvà D, et al. IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells. PLoS ONE. 2008;3:2634. [PMID: 18648544] CrossrefMedlineGoogle Scholar3. Jungwirth A, Schally AV, Pinski J, Groot K, Armatis P, Halmos G. Growth hormone-releasing hormone antagonist MZ-4-71 inhibits in vivo proliferation of Caki-I renal adenocarcinoma. Proc Natl Acad Sci U S A. 1997;94:5810-3. [PMID: 9159156] CrossrefMedlineGoogle Scholar4. Simmons JG, Ling Y, Wilkins H, Fuller CR, D'Ercole AJ, Fagin J, et al. Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth. Am J Physiol Gastrointest Liver Physiol. 2007;293:G995-1003. [PMID: 17823215] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Kaiser Franz Josef Hospital, 1100 Vienna, Austria.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults Ralf Nass , Suzan S. Pezzoli , Mary Clancy Oliveri , James T. Patrie , Frank E. Harrell Jr. , Jody L. Clasey , Steven B. Heymsfield , Mark A. Bach , Mary Lee Vance , and Michael O. Thorner Rejuvenation in Older Adults Receiving Oral Ghrelin Jim Webster Rejuvenation in Older Adults Receiving Oral Ghrelin Ralf M. Nass , Mary Lee Vance , and Michael O. Thorner Rejuvenation in Older Adults Receiving Oral Ghrelin Hernando Rafael Metrics 5 May 2009Volume 150, Issue 9Page: 654KeywordsAdverse eventsElderlyHematologic testsInsulin-like growth factorsMagnetic resonance imagingMusclesRenal cell carcinomaSarcomaSkeletal musclesUltrasound imaging ePublished: 5 May 2009 Issue Published: 5 May 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...