tbuckley/cabot-search huggingface dataset:
Functional beta3-adrenoceptor in the human heart.
Authors: C Gauthier, G Tavernier, F Charpentier, D Langin, H Le Marec
Journal: Journal of Clinical Investigation (1996)

Beta3-adrenoceptors are involved in metabolism, gut relaxation, and vascular vasodilation. However, their existence and role in the human heart have not been documented. We investigated the effects of several beta-adrenoceptor agonists and antagonists on the mechanical properties of ventricular endomyocardial biopsies. In the presence of nadolol, a beta1- and beta2-adrenoceptor antagonist, isoprenaline produced consistent negative inotropic effects. Similar negative inotropic effects also resulted from the action of beta3-adrenoceptor agonists with an order of potency: BRL 37344 > SR 58611 approximately CL 316243 > CGP 12177. The dose-response curve to BRL 37344-decreasing myocardial contractility was not modified by pretreatment with nadolol, but was shifted to the right by bupranolol, a nonselective beta-adrenoceptor antagonist. Beta3-adrenoceptor agonists also induced a reduction in the amplitude and an acceleration in the repolarization phase of the human action potential. Beta3-adrenoceptor transcripts were detected in human ventricle by a polymerase chain reaction assay. These results indicate that: (a) beta3-adrenoceptors are present and functional in the human heart; and (b) these receptors are responsible for the unexpected negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure.
Feeding of school children in a London borough.
Authors: A E Bender, M C Harris, A Getreuer
Journal: BMJ (1977)

A survey of 12 schools in a London borough showed that the protein and energy content of the average school meal was below the standard set by the Department of Health and Social Security for all age groups. Failure to meet the standards resulted from inadequate food purchases, poor menu planning and portion control, and several management problems. A 24-hour recall questionnaire showed that 5% of the pupils were "poorly" fed. These pupils were, however, no worse off than their "adequately" fed peers with regard to absences from school or academic attainment measured by reading quotient, but there was some slight difference in height and weight. The percentage of children having no breakfast increased from 4% in the infant schools to 21% in the senior schools. Two per cent of the senior pupils regularly ate no lunch.
AG73-modified Bubble liposomes for targeted ultrasound imaging of tumor neovasculature
Authors: Yoichi Negishi, Nobuhito Hamano, Yuka Tsunoda, Yusuke Oda, Batsuren Choijamts, Yoko Endo-Takahashi, Daiki Omata, Ryo Suzuki, Kazuo Maruyama, Motoyoshi Nomizu, Makoto Emoto, Yukihiko Aramaki
Journal: Biomaterials (2012)
Definition of rapid virologic response with a highly sensitive real-time PCR-based HCV RNA assay in peginterferon alfa-2a plus ribavirin response-guided therapy
Authors: Christoph Sarrazin, Mitchell L. Shiffman, Stephanos J. Hadziyannis, Amy Lin, Giuseppe Colucci, Hiroshi Ishida, Stefan Zeuzem
Journal: Journal of Hepatology (2010)
Splenectomy and the Thrombocytopenia of Systemic Lupus Erythematosus
Authors: PETER JACOBS
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 December 1986Splenectomy and the Thrombocytopenia of Systemic Lupus ErythematosusPETER JACOBS, LUCILLE WOOD, DAVID M. DENTPETER JACOBS, LUCILLE WOOD, DAVID M. DENTAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-6-971_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In 1985, Hall and colleagues (1) reported on 14 patients in whom platelet counts after splenectomy followed a different pattern from those in patients with idiopathic thrombocytopenic purpura treated in the same way. This experience differs from our own.In an analysis of 148 adults with immune thrombocytopenia (2), a subgroup of 8 patients with systemic lupus erythematosus responded to prednisone and subsequent splenectomy in a way that was indistinguishable from that of patients with the idiopathic variant. Two of the eight patients received only prednisone (1 mg/kg body weight · d). The first died at 3...References1. HALLMCCORMICKGREIPPMICHETMCKENNA SJPCC. Splenectomy does not cure the thrombocytopenia of systemic lupus erythematosus. Ann Intern Med. 1985;102:325-8. LinkGoogle Scholar2. JACOBSWOODDENT PLD. Results of treatment in immune thrombocytopenia. Q J Med. 1986;58:153-65. MedlineGoogle Scholar3. HAYESJACOBSWOODDENT MPLD. Splenic pathology in immune thrombocytopenia. J Clin Pathol. 1985;38:985-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Cape Town Leukaemia Centre Groote Schuur Hospital Cape Town South Africa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe diagnosis and management of the haematologic manifestations of lupusHaematological manifestations of lupusHematological Disorders in Patients with Systemic Lupus ErythematosusSplenectomy for thrombocytopenia associated with systemic lupus erythematosus in 11 Chinese patientsAutoimmune thrombocytopenia in primary antiphospholipidsyndrome and systemic lupus erythematosus: The response to splenectomyIntravenous gammaglobulin has no advantages over oral corticosteroids as primary therapy for adults with immune thrombocytopenia: A prospective randomized clinical trialHaematological manifestations of systemic lupus erythematosusIntermittent Cyclophosphamide for the Treatment of Autoimmune Thrombocytopenia in Systemic Lupus ErythematosusDimitrios T. Boumpas, MD, Shirin Barez, MD, John H. Klippel, MD, James E. Balow, MDThe comparison of gammaglobulin to steroids in treating adult immune thrombocytopenia 1 December 1986Volume 105, Issue 6Page: 971-972KeywordsBody weightIdiopathic thrombocytopenic purpuraLupus erythematosusPlateletsSplenectomy Issue Published: 1 December 1986 PDF DownloadLoading ...
Electrocardiographic QRS Axis Shift With Left Anterior Hemiblock
Authors: Gordon A. Ewy
Journal: JAMA (1971)

<h3>To the Editor.—</h3> This is, indeed, an interesting case. On two occasions their patient had normal conduction in the presence of hyperkalemia and abnormal or slowed conduction through the left anterior-superior division of the left bundle branch resulting in left axis deviation, with normal potassium levels. Later, this same patient showed left axis deviation with hyperkalemia that became normal following dialysis. There is a physiologic basis for decrease conduction with hyperkalemia,<sup>1</sup>and yet on occasion their patient had abnormal conduction through the left anterior superior division of the left bundle (LAH) with normal potassium levels. They conclude that there might be metabolic factors other than hyperkalemia that may account for the conduction delay. The ECGs with left axis deviation occurred when the heart rates were faster. Rate-related bundle branch block is well known,<sup>2</sup>and rate-related LAH is known to occur (Rosenbaum et al, 1969). A possible explanation for
Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes
Authors: Daniel Mucida, Mohammad Mushtaq Husain, Sawako Muroi, Femke van Wijk, Ryo Shinnakasu, Yoshinori Naoe, Bernardo Sgarbi Reis, Yujun Huang, Florence Lambolez, Michael Docherty, Antoine Attinger, Jr-Wen Shui, Gisen Kim, Christopher J Lena, Shinya Sakaguchi, Chizuko Miyamoto, Peng Wang, Koji Atarashi, Yunji Park, Toshinori Nakayama, Kenya Honda, Wilfried Ellmeier, Mitchell Kronenberg, Ichiro Taniuchi, Hilde Cheroutre
Journal: Nature Immunology (2013)
Evidence for an association between dehydroepiandrosterone sulfate and nonfatal, premature myocardial infarction in males.
Authors: L E Mitchell, D L Sprecher, I B Borecki, T Rice, P M Laskarzewski, D C Rao
Journal: Circulation (1994)

BACKGROUND Several studies indicate that endogenous hormones play a role in the etiology of coronary artery disease, either as independent risk factors or indirectly, via an effect on lipids, lipoproteins, or other heart disease risk factors. METHODS AND RESULTS The relation between endogenous hormone levels and premature (&lt; 56-year-old patients) myocardial infarction was assessed in a retrospective study involving 49 male survivors of premature myocardial infarction and 49 age-matched, volunteer male controls. Serum samples were obtained for each subject the morning after a &gt; or = 12-hour fast and frozen at -70 degrees C for subsequent hormonal analysis. Among the male patients, the average duration between the most recent myocardial infarction and blood sampling was 3.4 years (range, 0.7 to 19.2 years). Individuals reporting the use of any medications with the potential to alter lipid, lipoprotein, or hormone levels were excluded from these analyses. Dehydroepiandrosterone sulfate levels were significantly lower in the patients than in the control subjects. This association remained statistically significant even after accounting for the effects of total cholesterol, triglycerides, the ratio of total to high-density lipoprotein (HDL) cholesterol, HDL, apolipoprotein A-I, apolipoprotein A-II, apolipoprotein B, and body mass index. There were no significant differences in the levels of estradiol, testosterone, or free testosterone or the ratio of estradiol to testosterone between patients and control subjects. CONCLUSIONS Our conclusions are limited by the retrospective nature of this study. However, these data indicate that serum dehydroepiandrosterone sulfate levels are inversely related to premature myocardial infarction in males and that this association is independent of the effects of several known risk factors for premature myocardial infarction.
Norwegian doctor who has worked in Gaza is refused entry to Israel
Authors: O. Dyer
Journal: BMJ (2014)

A well known Norwegian anaesthesiologist who has helped to treat wounded people in Gaza during several wars has been barred from returning to the state and from entering Israel. 

Mads Gilbert, 67, has made repeated criticisms to international media about Israel’s blockade of Gaza and its military campaign. He was also one of 24 signatories of an “open letter for the people of Gaza” published in the Lancet this July, which was highly critical of Israel.1

Gilbert has worked as a visiting surgeon at Gaza’s main hospital, the Al-Shifa, during Operation Cast Lead in 2008-09, Operation Pillar of Defense in 2012, and Operation Protective Edge in 2014. During the first conflict, …
Was it a Case of Subacute Peritonitis?
Authors: J. Lue Sutherland
Journal: JAMA (1894)

Grand Island, Neb., Sept. 20, 1894. <h3>To the Editor:</h3> —I wish to report the following peculiar case and to ask the opinions of some of the many members of theAssociationas to the etiology and origin of the trouble: Mrs. D., aged 27, widow, almost three years; mother of three children, youngest 6 years and 8 months; aside from constipation of about eight years' standing, and an occasional sick headache, was considered healthy. Was taken with sharp colic pains in the stomach and upper abdomen on the morning of August 2. Saw her about 7 A.M. She located the onset of the pain in a small spot in the median line, just below the ensiform cartilage. She had eaten nothing hurtful. There was no tendency to vomiting, or diarrhea, and the temperature was normal. The pain was quickly subdued by a hypodermic of morphia one-fourth grain. Hot turpentine cloths
Possible involvement of SDF-1/CXCL12 in the pathogenesis of Degos disease
Authors: Jitlada Meephansan, Mayumi Komine, Satomi Hosoda, Hidetoshi Tsuda, Masaru Karakawa, Satoru Murata, Toshio Demitsu, Mamitaro Ohtsuki
Journal: Journal of the American Academy of Dermatology (2012)
Relationship between Scar Size and Characteristics by ce-CMR and Tpeak-Tend Interval in Post-MI Patients with Relatively Preserved LV Functions and Nonsustained Ventricular Tachycardia
Authors: Kivanc Yalin, Ebru Golcuk, Hakan Buyukbayrak, Ekrem Bilal Karaayvaz, Cansu Selcan Akdeniz, Ravza Yilmaz, Memduh Dursun, Ahmet Kaya Bilge, Kamil Adalet
Journal: Journal of the American College of Cardiology (2013)
Another Perfect Treadmill Test?
Authors: L. Thomas Sheffield
Journal: New England Journal of Medicine (1985)

IN 1980 Hollenberg et al. reported a means of scoring the electrocardiographic response to treadmill exercise, which resulted in a much better correlation with coronary angiographic results than was being reported in other comparative studies.1 They subsequently reported that this treadmill score accurately reflected the degree of revascularization after coronary artery bypass surgery.2 In this issue Hollenberg and colleagues report the results of tests in 377 asymptomatic, apparently healthy Air Force officers who had no overt coronary artery disease.3 Ten of the subjects judged to have the most risk factors for coronary artery disease, including the three with abnormal treadmill . . .
Bispecific antibodies targeting tumor-associated antigens and neutralizing complement regulators increase the efficacy of antibody-based immunotherapy in mice
Authors: P Macor, E Secco, N Mezzaroba, S Zorzet, P Durigutto, T Gaiotto, L De Maso, S Biffi, C Garrovo, S Capolla, C Tripodo, V Gattei, R Marzari, F Tedesco, D Sblattero
Journal: Leukemia (2014)
TCT-724 Low-Flow Low-Gradient Severe Aortic Stenosis by Echocardiography Does Not Reliably Predict Aortic Stenosis Classification by Invasive Hemodynamics
Authors: Troy M. LaBounty, Stanley Chetcuti, G Michael Deeb, Himanshu J. Patel, Paul M. Grossman, Anna Booher, Antonio Hernandez Conte, Rhonda Miyasaka, Smita Patel, Ella Kazerooni, David S. Bach
Journal: Journal of the American College of Cardiology (2013)
Hemochromatosis and ?HLA-H?: Definite!
Authors: E C Jazwinska, L W Powell
Journal: Hepatology (1997)

Hereditary hemochromatosis (HH), which affects some 1 in 400 and has an estimated carrier frequency of 1 in 10 individuals of Northern European descent, results in multi-organ dysfunction caused by increased iron deposition, and is treatable if detected early. Using linkage-disequilibrium and full haplotype analysis, we have identified a 250kb region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes. Within this region, we have identified a gene related to the MHC class I family, termed HLA-H, containing two missense alterations. One of these is predicted to inactivate this class of proteins and was found homozygous in 83% of 178 patients. A role of this gene in hemochromatosis is supported by the frequency and nature of the major mutation and prior studies implicating MHC class I-like proteins in iron metabolism.
<i>CD226</i> (<i>DNAM-1</i>) is associated with susceptibility to juvenile idiopathic arthritis
Authors: T H C M Reinards, H M Albers, D M C Brinkman, S S M Kamphuis, M A J van Rossum, H J Girschick, C Wouters, E P A H Hoppenreijs, R K Saurenmann, A Hinks, J A Ellis, E Bakker, W Verduijn, P Slagboom, T W J Huizinga, R E M Toes, J J Houwing-Duistermaat, R ten Cate, M W Schilham
Journal: Annals of the Rheumatic Diseases (2014)

Objectives Juvenile idiopathic arthritis (JIA) is considered a complex genetic autoimmune disease. We investigated the association of genetic variants previously implicated in JIA, autoimmunity and/or immunoregulation, with susceptibility to JIA. Methods A genetic association study was performed in 639 JIA patients and 1613 healthy controls of northwest European descent. Ninety-three single nucleotide polymorphisms (SNP) were genotyped in a candidate gene approach. Results of the entire JIA patient group (all subtypes) were compared with results obtained, alternatively, with a clinically homogeneous patient group including only oligoarticular and rheumatoid factor (RF) negative polyarticular JIA patients (n=493). Meta-analyses were performed for all SNPs that have been typed in other Caucasian JIA cohorts before. Results SNPs in or near PTPN22 , VTCN1 , the IL2-IL21 region, ANKRD55 and TNFA were confirmed to be associated with JIA (p&lt;0.05), strengthening the evidence for involvement of these genes in JIA. In the majority of these replicated SNPs, effect sizes were larger when analysing a homogeneous patient cohort than when analysing all subtypes. We identified two novel associations with oligoarticular and RF-negative polyarticular JIA: CD226 rs763361 (OR 1.30, 95% CI 1.12 to 1.51, p=0.0006) and CD28 rs1980422 (OR 1.29, 95% CI 1.07 to 1.55, p=0.008). Meta-analyses including reported studies confirmed the association of both SNPs with susceptibility to JIA (OR 1.16, p=0.001 and OR 1.18, p=0.001, for rs763361 and rs1980422, respectively). Conclusions The CD226 gene has been identified as novel association with JIA, and a SNP near CD28 as a suggestive association. Both genes are probable candidate risk factors, since they are involved in costimulation of T cells.
Spinal disease presenting as acute abdominal pain: report of two cases.
Authors: R Jooma, M J Torrens, R J Veerapen, H B Griffith
Journal: BMJ (1983)

Successive generations of surgeons have been taught the importance of considering spinal disease in the differential Lesions of the dorsal spine m diagnosis of abdominal pain1 but with the passing of tabes abdominal pain before the onset dorsalis as a clinical problem and the increasing rarity of infective and this may result in an inapproprih lesions of the spine the lesson seems to require reinforcing.WeIt is important to bear the syndr recently managed two patients with spinal lesions who initially particularly in diabetics and childrer presented with abdominal pain leading in both cases to an inappropriate surgical exploration before the onset of cord compression revealed the true nature of the problem. Case reportsCase 1-A 48 year old man with mild diabetes was admitted to hospital on 4 September 1982 with severe right hypochondrial pain and fever.His diabetes had been controlled by diet alone and he was well until three weeks before admission when he developed lower dorsal back pain which progressively increased in severity and became girdle-like with radiation to the front of the trunk, particularly on the right.In the three days before admission the anterior component of his pains became exacer- bated and in addition he had fever, sweating, and nausea.Though he looked unwell there were no unequivocal abdominal signs and he was observed for 24 hours.His haemoglobin concentration was 13 g/dl, the white cell count was 12-0 x 109/1, and the blood sugar concentration 12 5 mmol/l (225 mg/100 ml).His pains continued and in addition the abdomen distended with dilated loops of bowel seen on a radiograph.Treatment was started with metformin and he underwent an exploratory laparotomy which gave negative results.His back pain continued and he developed an abdominal wound infection but was allowed home, only to be readmitted on 29 September.On this occasion his dorsal pain radiated to the lower chest on the left and was associated with pain and weakness in the left leg.Deep venous thrombosis with pulmonary embolism was suspected and he was given anticoagulants.This treatment was discontinued two days later when findings of the chest x ray examination and a ventila- tion-perfusion scan failed to substantiate the diagnosis.The weakness of his leg became a paraparesis with extensor plantar responses.On 7 October he was noted to have a sensory level at D7 and was paraplegic and incontinent of urine.A myelogram now showed a complete block at D9; laminectomy was under- taken immediately, and an extradural abscess was evacuated.
THE TREATMENT OF LUPUS VULGARIS.
Authors: G. H. LANCASHIRE
Journal: British Journal of Dermatology (1931)

Journal Article THE TREATMENT OF LUPUS VULGARIS. Get access G. H. LANCASHIRE, M.D. G. H. LANCASHIRE, M.D. Physician, Manchester and Salford Hospital for Diseases of the Skin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 43, Issue 3, 1 March 1931, Pages 109–115, https://doi.org/10.1111/j.1365-2133.1931.tb09474.x Published: 01 March 1931
The problems that generate the rationality debate are too easy, given what our economy now demands
Authors: Selmer Bringsjord, Yingrui Yang
Journal: Behavioral and Brain Sciences (2003)

Stanovich &amp; West (S&amp;W), following all relevant others, define the rationality debate in terms of human performance on certain well-known problems. Unfortunately, these problems are very easy. For that reason, if System 2 cognition is identified with the capacity to solve them, such cognition will not enable humans to meet the cognitive demands of our technological society. Other profound issues arise as well.
Triamcinolone Injections In Herpes Zoster Lesions
Authors: Ervin Epstein
Journal: JAMA (1969)

To the Editor:—  In today's scientifically oriented medical world, new therapeutic maneuvers are not accepted without statistically significant series supported by valid controls. Yet, there are some instances in which the success of the therapy and the seriousness of the condition as measured by morbidity, disability, and even death make it mandatory that knowledge about a promising approach be brought to the attention of the practicing physician prior to the time that all scientific challenges can be met and conquered.  Herpes zoster is such a disease. While the condition is capricious in its response to treatment, postzoster neuralgia tends to be constant and therapeutically resistant. Feeling that it would be unwise to maintain silence in this matter, the following therapeutic suggestion is being made. Its value, or lack thereof, can be established only by usage in many patients by multiple practitioners. However, in my hands, this has superseded all other
Poetry to exercise the brain
Authors: Farhat Yaqub
Journal: The Lancet Neurology (2013)

The Little Book of Neuroscience Haikus contains more than 100 poems by Eric Chudler about the brain. Poetry seems like an innovative way to learn some facts about neuroscience, particularly for people who might not know much about the subject. Chudler has written these non-rhyming poems in the style of the Japanese haikus, consisting of three lines and 17 syllables—five, seven, and five. The poems are succinct and provide some salient information about different areas of the brain. All are followed by an explanation and a few are accompanied by simple illustrations.
Scoring posters at scientific meetings: first impressions count
Authors: P. E M Smith, G. Fuller, F. Dunstan
Journal: Journal of the Royal Society of Medicine (2004)

Many specialist societies present ‘best poster’ prizes, yet without generally agreed assessment methods. 31 posters at a neurology meeting were divided randomly into two sets; 14 neurologists, randomized into two groups, were each assigned one poster set. They ‘quick scored’ the first half, viewing posters for 10-15 seconds, and ‘detailed scored’ the others. 11 administrators and pharmaceutical representatives quick scored all posters. Neurologists’ quick score ranking correlated highly (r=0.75) with other neurologists’ detailed score ranking, and identified four of their six top-ranked posters. Correlations were strongest for presentation (r=0.65), message (r=0.65) and star-quality (r=0.64), but weak for facts (r=0.09), originality (r=0.15) or science (r=0.02). Non-neurologists could not identify the posters ranked highest by neurologists. We conclude that quick ranking by specialists can efficiently identify the best posters for more detailed assessment. On this basis we offer poster-scoring guidelines for use at scientific meetings.
The Central Clock in Patients With Parkinson Disease—Reply
Authors: Aleksandar Videnovic, David P. Breen, Roger A. Barker, Phyllis C. Zee
Journal: JAMA Neurology (2014)

In Reply We read with interest the letter to the editor by Fifel and DeBoer. Their comments focus on 3 published studies that shed light on circadian function in Parkinson disease (PD) and its possible link to frequently disrupted sleep-wake cycles in the PD population.