tbuckley/cabot-search huggingface dataset:
Acid hydrolases in psoriatic epidermis
Authors: P.D. Mier, Jose J.M.A. Hurk
Journal: British Journal of Dermatology (1976)

Journal Article Acid hydrolases in psoriatic epidermis Get access P.D. Mier, P.D. Mier Department of Dermatology, University of Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar José J.M.A. van den Hurk José J.M.A. van den Hurk Department of Dermatology, University of Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 94, Issue 2, 1 February 1976, Pages 219–220, https://doi.org/10.1111/j.1365-2133.1976.tb04373.x Published: 01 February 1976
Should Response to Preoperative Chemotherapy Affect Radiotherapy Recommendations After Mastectomy for Stage II Breast Cancer?
Authors: Jennifer R. Bellon, Julia S. Wong, Harold J. Burstein
Journal: Journal of Clinical Oncology (2012)

Article Tools ONCOLOGY GRAND ROUNDS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2012.44.3358 Journal of Clinical Oncology - published online before print October 1, 2012 PMID: 23032626 Should Response to Preoperative Chemotherapy Affect Radiotherapy Recommendations After Mastectomy for Stage II Breast Cancer? Jennifer R. BellonxJennifer R. BellonSearch for articles by this author , Julia S. WongxJulia S. WongSearch for articles by this author , Harold J. BursteinxHarold J. BursteinSearch for articles by this author Show More Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA https://doi.org/10.1200/JCO.2012.44.3358 First Page Full Text PDF Figures and Tables © 2012 by American Society of Clinical Oncology
Hepatic Injury in 12 Patients Taking the Herbal Weight Loss Aids Chaso or Onshido
Authors: Masayuki Adachi, Hidetsugu Saito, Hisashi Kobayashi, Yoshinori Horie, Shinzo Kato, Masahiro Yoshioka, Hiromasa Ishii
Journal: Annals of Internal Medicine (2003)

Background: The Chinese herbal dietary supplements Chaso and Onshido are marketed for weight loss in Japan. The safety of these weight loss aids is unknown. Objective: To describe patients who developed liver injury while taking Chaso or Onshido. Design: Case series. Setting: Keio University Hospital, Tokyo, Japan, and other hospitals in Japan. Patients: 6 patients who took Chaso and 6 patients who took Onshido before presenting with liver injury. Measurements: Pathologic, clinical, and laboratory evaluations and chemical analysis of the herbal weight loss aids. Results: All 12 patients developed acute liver injury characterized by a marked increase in serum liver chemistry values (mean alanine aminotransferase level, 1978 U/L [range, 283 to 4074 U/L]) after ingesting these products. Two patients developed fulminant hepatic failure: 1 patient required liver transplantation, and the other patient died. N-nitroso-fenfluramine, a variant of the appetite-depressant drug fenfluramine, was present in these products. Conclusions: The use of the weight loss aids Chaso and Onshido may be associated with acute liver injury. N-nitroso-fenfluramine is a possible hepatotoxic ingredient.
Possible Reproductive Detriment in LSD Users
Authors: Cecil B. Jacobson, Cheston M. Berlin
Journal: JAMA (1972)

One hundred forty women and their consorts, admitting to the use of lysergic acid diethylamide (LSD) prior to or during pregnancy were observed through 148 pregnancies. There were 83 live newborns; 8 had major congenital defects. There were 65 abortions; 53 therapeutic and 12 spontaneous. Four of 14 embryos from therapeutic abortions showed gross anomalies. Forty-three percent of first-trimester pregnancies ended in spontaneous abortions. Four of eight serial pregnancies resulted in defective embryos or infants. Eight of 12 women have been unable to conceive again over an 18-month period. The ingestion of other illicit drugs, the presence of infectious disease, and marginal maternal nutrition preclude a definitive correlation of increased reproductive risk with LSD ingestion. The presence of LSD ingestion, coupled with studies in animals and supported by DNA studies, suggests that LSD might be hazardous to human reproduction.
The Treatment of Acne
Authors: Henry Wm. Blanc
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STERILE SOAP MACHINE.
Authors: J. H. FIRESTONE
Journal: JAMA (1902)

The accompanying cut shows something new in the line of a foot-power sterile soap machine for use in operating rooms. It consists of a cylinder and plunger, operated by foot power, applied to a ratchet wheel acting upon the arm of the piston by a double-thread screw, which forces the plunger into the cylinder. There are two blank screw caps that go with each cylinder. The plunger, cylinder and contents are sterilized before using. The machine is taken from the bracket and the plunger removed from the cylinder; then the cylinder is filled with green soap and the blank caps are screwed on either end. The filled cylinder and plunger are then sterilized. After sterilizing the blank caps are taken off, the plunger is adjusted and the machine is placed in the bracket ready to operate. The machine is made in three sizes, each containing ½, 1 or 2 pounds
A Double-Blind Comparison of Lithium and Chlorpromazine in the Treatment of Manic States
Authors: GOTTFRIED SPRING, DANIEL SCHWEID, CARL GRAY, JOEL STEINBERG, MARC HORWITZ
Journal: American Journal of Psychiatry (1970)

Lithium, at a dosage of 1,800 mg. daily, was found to be effective in the treatment of acute manic states. However, when compared with chlorpromazine by means of a double-blind technique using stringent diagnostic criteria, no significant difference between the two drugs was noted. In regard to the prophylactic effect of lithium, the data presented indicate that this question is still unresolved.
Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk.
Authors: D Dowbenko, A Kikuta, C Fennie, N Gillett, L A Lasky
Journal: Journal of Clinical Investigation (1993)

Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) is a mucinlike endothelial glycoprotein that acts as an adhesive ligand for L selectin by presenting one or more O-linked carbohydrates to the lectin domain of this leukocyte cell surface selectin. The GlyCAM 1 glycoprotein has been previously shown to be expressed specifically by the endothelial cells of peripheral and mesenteric lymph nodes and in an unknown site in lung. Here we report that this protein is also expressed during lactation by mammary epithelial cells. Northern blot analysis has shown that the mRNA for GlyCAM 1 appears to be induced during pregnancy in a manner similar to that previously described for hormonally induced milk proteins. In situ hybridization analysis reveals that the site of GlyCAM 1 synthesis in the mammary gland is in the epithelial cells that produce these same milk proteins. Immunohistochemistry of mammary glands using antisera directed against GlyCAM 1 peptides demonstrates that these epithelial cells contain GlyCAM 1 protein, and that this protein is also found lumenally in the milk of the secreting mammary gland. Analysis of murine milk shows that immunoreactive GlyCAM 1 is found in the soluble whey fraction. Finally, labeling analysis of milk GlyCAM 1 has demonstrated that this form of the glycoprotein lacks the sulfate-modified carbohydrate that has recently been shown to be required for the ligand binding activity to L selectin. The nonsulfated mammary GlyCAM 1 is unable to interact with L selectin, consistent with the hypothesis that milk GlyCAM 1 has a different function than endothelial GlyCAM 1. These data thus suggest that milk GlyCAM 1 is a hormonally regulated milk protein that is part of the milk mucin complex. In addition, the finding that the mammary form of GlyCAM 1 contains different carbohydrate modifications than the endothelial form suggests that this glycoprotein may be a scaffold for carbohydrates that mediate functions in addition to cell adhesion.
Altered myocardial force-frequency relation in human heart failure.
Authors: L A Mulieri, G Hasenfuss, B Leavitt, P D Allen, N R Alpert
Journal: Circulation (1992)

BACKGROUND In congestive heart failure (idiopathic dilated cardiomyopathy), exercise is accompanied by a smaller-than-normal decrease in end-diastolic left ventricular volume, depressed peak rates of left ventricular pressure rise and fall, and depressed heart-rate-dependent potentiation of contractility (bowditch treppe). We studied contractile function of isolated left ventricular myocardium from New York Heart Association class IV-failing and nonfailing hearts at physiological temperature and heart rates in order to identify and quantitate abnormalities in myocardial function that underlie abnormal ventricular function. METHODS AND RESULTS The isometric tension-generating ability of isolated left ventricular strips from nonfailing and failing human hearts was investigated at 37 degrees C and contraction frequencies ranging from 12 to 240 per minute (min-1). Strips were dissected using a new method of protection against cutting injury with 2,3-butanedione monoxime (BDM) as a cardioplegic agent. In nonfailing myocardium the twitch tension-frequency relation is bell-shaped developing 25 +/- 2 mN/mm2 at a contraction frequency of 72 min-1 and peaking at 44 +/- 3.7 mN/mm2 at a contraction frequency of 174 +/- 4 min-1. In failing myocardium the peak of the curve occurs at lower frequencies between 6 and 120 min-1 averaging 81 +/- 22 min-1, and it develops 48% (p less than 0.001) and 80% (p less than 0.001) less tension than in nonfailing myocardium at 72 and 174 min-1, respectively. Between 60 and 150 min-1 tension increases by 107% in nonfailing myocardium, but it does not change significantly in failing myocardium. Peak rates of rise and fall of isometric twitch tension vary in parallel with twitch tension as stimulation frequency rises in nonfailing myocardium but not in failing myocardium. CONCLUSIONS The quantitative agreement between these results from isolated myocardium and those from catheterization laboratory measurements on intact humans suggest that alterations of myocardial origin, independent of systemic factors, may contribute to the above mentioned abnormalities in left ventricular function seen in dilated cardiomyopathy.
Alcohol and Society
Authors: Jackson A. Smith
Journal: JAMA (1971)

<h3>To the Editor.—</h3> It is no secret among members of the American Medical Association or the public in general that alcoholism is a most difficult and complex illness. Consequently, the article "Alcohol and Society" (<b>216</b>: 1011, 1971) with its unbelievably simplistic solutions to this problem seemed more fitting as a Women's Christian Temperance Union hand-out than a summation inThe Journal. For example, social drinking, "excessive drinking," and alcoholism are apparently all one and the same, and in fact any use of alcohol seems to pose quite a hazard. This homily really puts out some pretty obvious folklore, such as "alcohol is used as an adjunct for social activity" and not all people who drink and drive have wrecks (this seems plausible since at least 20 million a day perform this feat and there are not quite that many wrecks). In other areas the observations tend to incompleteness, perhaps to
A Multifactorial System for Equitable Selection of Cadaver Kidney Recipients
Authors: Thomas E. Starzl
Journal: JAMA (1987)

During 1986, a total of 270 cadaver renal transplantations were performed at the University of Pittsburgh. Kidneys were allocated by a point system that awarded points to recipients for waiting time, antigen matching, antibody analyses, medical urgency, and logistic practicality. Kidneys were given to patients with the highest point totals in 98% of cases. To our knowledge, this is the first such multifactorial system for cadaver kidney allocation. Possibly it may be modified for extrarenal organs. (<i>JAMA</i>1987;257:3073-3075)
Factors Influencing Conversion of Chronic Atrial Fibrillation with Special Reference to Serum Quinidine Concentration
Authors: MAURICE SOKOLOW, ROBERT E. BALL
Journal: Circulation (1956)

Opinion differs greatly about the value and risk of quinidine. The present communication attempts to demonstrate that more rational use of quinidine is possible by emphasis on serum quinidine concentration rather than on dose alone. Conversion of chronic atrial fibrillation and the appearance of myocardial toxicity are related more closely to the concentration of quinidine in the blood than to the dose. The serum concentration achieved with equal doses of the drug varied strikingly in different individuals; myocardial toxicity was infrequent at levels less than 6.0 /g=m/g./ml. and increased proportionately as this level was exceeded. These levels could not always be predicted from the dose given.
External Electrical Termination of Supraventricular Arrhythmias in Congenital Heart Disease
Authors: MILTON H. PAUL, ROBERT A. MILLER
Journal: Circulation (1962)

Persistent supraventricular arrhythmias of the flutter or fibrillation-flutter type have been terminated by elective external electric countershock in three patients after drug therapy had been unsuccessful. It is suggested that this technic is a relatively safe and effective treatment for supraventricular as well as ventricular arrhythmias when anti-arrhythmic drugs have proved ineffective.
Survival and cause specific mortality in patients with inflammatory bowel disease: a long term outcome study in Olmsted County, Minnesota, 1940-2004
Authors: T Jess
Journal: Gut (2006)

We followed a population based cohort of patients with inflammatory bowel disease (IBD) from Olmsted County, Minnesota, in order to analyse long term survival and cause specific mortality.A total of 692 patients were followed for a median of 14 years. Standardised mortality ratios (SMRs, observed/expected deaths) were calculated for specific causes of death. Cox proportional hazards regression was used to determine if clinical variables were independently associated with mortality.Fifty six of 314 Crohn's disease patients died compared with 46.0 expected (SMR 1.2 (95% confidence interval (CI) 0.9-1.6)), and 62 of 378 ulcerative colitis (UC) patients died compared with 79.2 expected (SMR 0.8 (95% CI 0.6-1.0)). Eighteen patients with Crohn's disease (32%) died from disease related complications, and 12 patients (19%) died from causes related to UC. In Crohn's disease, an increased risk of dying from non-malignant gastrointestinal causes (SMR 6.4 (95% CI 3.2-11.5)), gastrointestinal malignancies (SMR 4.7 (95% CI 1.7-10.2)), and chronic obstructive pulmonary disease (COPD) (SMR 3.5 (95% CI 1.3-7.5)) was observed. In UC, cardiovascular death was reduced (SMR 0.6 (95% CI 0.4-0.9)). Increased age at diagnosis and male sex were associated with mortality in both subtypes. In UC but not Crohn's disease, a diagnosis after 1980 was associated with decreased mortality.In this population based study of IBD patients from North America, overall survival was similar to that expected in the US White population. Crohn's disease patients were at increased risk of dying from gastrointestinal disease and COPD whereas UC patients had a decreased risk of cardiovascular death.
Nutritional Consequences of Reducing Sodium Intake
Authors: ALTA M. ENGSTROM
Journal: Annals of Internal Medicine (1983)

An increased awareness of sodium's possible relation to hypertension has resulted in many Americans trying to avoid foods high in sodium without realizing the nutritional risks taken when these foods are eliminated from the diet. A recent study shows that a significant proportion of the population is consuming less than 66% of the recommended dietary allowance for calcium, iron, magnesium, and vitamin B6. Most of the population's daily sodium intake is from foods in the meat, grain, and milk food groups. Foods contributing sodium to the diet also contribute other essential nutrients currently consumed at inadequate levels by many Americans. There is a risk in reducing foods containing sodium from the diet without considering other nutrients. Emphasis should be on eliminating discretionary salt and selecting a balanced diet from the basic five food groups.
Do oxysterols control cholesterol homeostasis?
Authors: Ingemar Björkhem
Journal: Journal of Clinical Investigation (2002)

Oxysterols are oxygenated derivatives of cholesterol with a very short half-life relative to cholesterol.As a consequence they are present in very low concentrations in all mammalian systems, almost invariably accompanied by 10 3 -to 10 6 -fold excess of cholesterol.Oxysterols are important intermediates in a number of hepatic and extrahepatic catabolic pathways, most of which generate water-soluble bile acids as final products.Based on largely indirect evidence, and in spite of their low levels in vivo, oxysterols are generally believed to be important physiological mediators of cholesterol-induced effects.Perhaps the best support for this model is the existence of nuclear receptors that bind these compounds with high affinity and the fact that oxysterols potently regulate the expression of sterol-sensitive genes in vitro.Here I consider the role of oxysterols as intermediates in different catabolic pathways, and I weigh the evidence for and against the "oxysterol hypothesis" of cholesterol homeostasis.
CLINICAL AND ANGIOGRAPHIC CHARACTERISTICS OF CORONARY ENDOTHELIAL DYSFUNCTION SEVERITY IN PATIENTS WITH MYOCARDIAL BRIDGE AS ASSESSED BY ACETYLCHOLINE PROVOCATION TEST
Authors: Meera Kumari, Seung-Woon Rha, Kanhaiya L. Poddar, Ji Young Park, Byoung Geol Choi, Yun Kyung Kim, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2011)
Dihydroergotamine-Heparin Prophylaxis of Postoperative Deep Vein Thrombosis
Authors: Mason G. Robertson
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The question not asked in the multicenter trial study<sup>1</sup>is, who does not need dihydroergotamine and heparin prophylaxis against DVT during major surgery? Nor is the question raised by Jack Hirsh<sup>2</sup>in his editorial in the same issue. The study, of course, asked the question, "Does this prophylaxis work?" The answer was in the affirmative. Yet, my question is not unimportant. Many will conclude from this study that<i>all</i>patients older than 40 years undergoing major surgery, barring a contraindication, should have this prophylaxis. They would fall into the category of followers of the American Hippocrates, Dr Benjamin Rush, who did not believe in<i>vis medicatrix naturae</i>but that the wise physician<i>always</i>interceded and left nothing to nature or to chance.<sup>3</sup>Others might consider that of the overall 880 patients studied, subtracting all of those in whom DVT developed in the placebo and
Pathologic Echocardiographic Findings In Turkish Adults: An Epidemiologic Observational Study
Authors: Sübhan Yalcın, Yasin Türker, Hakan Ozhan, Yusuf Aslantas, Yasemin Türker, İsmail Ekinözü, Hakan Tibilli, Ahmet Karabacak
Journal: Journal of the American College of Cardiology (2013)
GENTLENESS IN GENITO-URINARY SURGERY
Authors: J. BAYARD CLARK
Journal: JAMA (1926)

With the foregoing title in mind, I have stood on the edge of this short literary outburst for several years; years that have only emphasized the more the importance of this subject. Twenty years ago in the early moments of our fierce scientific surgical ardor, such a title would have seemed rather too effeminate to adorn a serious surgical essay. Today the situation is somewhat different, for the avoidance of trauma has come to have a new significance to the thoughtful student of contemporaneous surgery. Back in days much earlier, when hospitals and surgical workshops were germ-ridden with organisms of exalted virulence, a surgical operation, with trauma or without trauma, was more likely than not to be followed by grave septic complications, and a fatal issue was a common conclusion. Then came the era that gave us antisepsis. Then asepsis itself came, with its marvelous results, as compared with the
Who Was Daniel Drake?
Authors: Lester S. King
Journal: JAMA (1985)

In American history the key word is<i>expansion</i>. The original 13 colonies were settled on the Eastern Seaboard, limited, for practical purposes, by the Appalachian Mountains. Well before the Revolution, solitary pioneers, of whom Daniel Boone was the most famous, did indeed carry out important explorations across the Appalachian Mountains, but penetration westward remained halting and irregular until after the colonies became welded into a new nation. As with virtually all folk migrations, population pressures induced hardy and ambitious settlers to seek new land, new opportunities. Physical difficulties of terrain, and the hostility of Indians whose lands were being ruthlessly seized, served as counterbalancing forces, but population pressures were not to be denied. The new government had wisely established what might be called a reservoir of land open to settlers. In the latter 18th century the best route to the so-called Northwest Territory lay along the Ohio Valley. Roads were