tbuckley/cabot-search huggingface dataset:
Host-derived circulating cells do not significantly contribute to cardiac regeneration in heterotopic rat heart transplants
Authors: S AUSONI, T ZAGLIA, A DEDJA, R DILISI, M SEVESO, E ANCONA, G THIENE, E COZZI, S SCHIAFFINO
Journal: Cardiovascular Research (2005)

Objectives: The aim of this study was to investigate the contribution of host-derived circulating cells to cardiac repair after tissue damage using the model of heterotopic heart transplantation between transgenic recipient rats expressing green fluorescent protein (GFP) and wild-type donors.
An Electron Microscope Study of Islet Cell Adenomas
Authors: Marie H. Greider
Journal: JAMA (1963)

THE ULTRASTRUCTURAL characteristics of the islet cells of the pancreas are sufficiently different to permit identification of cell types without recourse to the selective staining methods required for light microscopy.<sup>1-3</sup>Such tinctorial methods often fail to indicate the cell type present in pancreatic tumors. This electron microscope study was undertaken to define the ultrastructural appearance of islet cell adenomas of different functional properties and to compare these tumor cells with the ultrastructural appearance of islet cells. <h3>Materials and Methods</h3> Biopsy specimens were obtained at surgery from two pancreatic tumors which exhibited the Zollinger-Ellison syndrome (recurrent peptic ulceration, gastric hypersecretion, and an adenoma of the pancreatic islets which does not produce insulin) and from the uninvolved parts of these pancreases. Specimens were also obtained from four tumors taken from patients who exhibited Whipple's triad (convulsions and coma accompanied by blood glucose levels of less than 50 mg% and relieved at
SURGERY OF THE LUNG.
Authors: J. B. MURPHY
Journal: JAMA (1898)

<h3>INFECTIVE LESIONS OF THE LUNG WHICH CONCERN THE SURGEON.</h3> The surgical infective lesions of the lung are abscess, bronchiectasis, gangrene, foreign bodies, cysts (echinococcus and dermoide), tuberculosis and actinomycosis. Abscess of the lung is not as common a pulmonary affection as might be inferred from the number of cases reported as such in the literature. A careful scrutiny shows that a considerable percentage of the cases reported as abscesses are empyema communicating with the bronchus, subdiaphragmatic abscess rupturing into a bronchus, or circumscribed interlobar pleurisies. Abscess—Etiology.—The most common cause of abscess of the lung is: 1, acute circumscribed inflammation, as pneumonia, followed by necrosis and softening of the lung, 46 per cent.; 2, peribronchitis; 3, septic embolism of the pulmonary artery, or a single branch of the bronchial (pyemic embolism), 3 per cent.;<sup>43</sup>4, rapid tuberculary caseation and necrosis, with secondary infection; 5, perforation of the lung by infection from malignant diseases
Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 as Predictors of Advanced-Stage Prostate Cancer
Authors: J. M. Chan
Journal: JNCI Journal of the National Cancer Institute (2002)

Background: Plasma levels of insulin-like growth factor-I (IGF-I) have been associated with the risk of prostate cancer. However, the association of IGF-I with specific tumor stage and grade at diagnosis, which correlate with risk of recurrence and mortality, has not been studied rigorously. To determine whether plasma levels of IGF-I and its main circulating binding protein, IGF binding protein-3 (IGFBP-3), predict more aggressive forms of prostate cancer, we investigated the association between plasma levels of each and specific stages and grades of prostate cancer. Methods: We examined 530 case patients and 534 control subjects in a nested case–control study in the prospective Physicians' Health Study. Patients with prostate cancer diagnosed from 1982 through 1995 were matched to control subjects by age and smoking status. IGF-I and IGFBP-3 were measured in prospectively collected plasma samples. Conditional logistic regression models were used to estimate the relative risks (RRs) for prostate cancer associated with IGF-I and IGFBP-3, stratified on grade (Gleason score ≥7 versus <7) and stage (early = stage A or B prostate cancer versus advanced = stage C or D prostate cancer). All statistical tests were two-sided. Results: Plasma levels of IGF-I and IGFBP-3 were predictors of advanced-stage prostate cancer (RR = 5.1, 95% confidence interval [CI] = 2.0 to 13.2 for highest versus lowest quartiles of IGF-I; RR = 0.2, 95% CI = 0.1 to 0.6 for highest versus lowest quartiles of IGFBP-3) but not of early-stage prostate cancer. Neither was differentially associated with Gleason score. Men with high IGF-I levels and low IGFBP-3 levels had an RR for advanced-stage prostate cancer of 9.5 (95% CI = 1.9 to 48.4) compared with men with low levels of both. Combining IGF-I and IGFPB-3 measurements with a standard prostate-specific antigen (PSA) measurement for prostate cancer screening increased the specificity (from 91% to 93%) but decreased sensitivity (from 40% to 36%) compared with measurement of PSA alone. Conclusions: Circulating levels of IGF-I and IGFBP-3 may predict the risk of developing advanced-stage prostate cancer, but their utility for screening patients with incident prostate cancer may be limited.
How Well Does the New Lung Cancer Staging System Predict for Local/Regional Recurrence After Surgery?: A Comparison of the TNM 6 and 7 Systems
Authors: Joseph M. Pepek, Junzo P. Chino, Lawrence B. Marks, Thomas A. D'Amico, David S. Yoo, Mark W. Onaitis, Neal E. Ready, Jessica L. Hubbs, Jessamy Boyd, Chris R. Kelsey
Journal: Journal of Thoracic Oncology (2011)
TIME IN THERAPEUTIC RANGE ≥55% VERSUS &lt;55% ON WARFARIN THERAPY OUTCOMES IN NON-VALVULAR ATRIAL FIBRILLATION PATIENTS
Authors: Jaejin An, Daniel Lang, Niu Fang, Kristin Jazdzewski, Paul Le, Nazia Rashid, Brian Meissner, Robert Mendes, Diana Dills, Dan Ershoff, Gerald Borok, Amanda Bruno
Journal: Journal of the American College of Cardiology (2014)
TCT-550 The Impact Of Upstream Anticoagulation On In-Hospital Bleeding In Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Authors: Joshua Loh, Hironori Kitabata, Israel Barbash, Danny Dvir, Salem Badr, Rebecca Torguson, Kenneth Kent, Lowell Satler, William Suddath, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2012)
Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis
Authors: Katja Derkow, Christoph Loddenkemper, Justine Mintern, Nils Kruse, Katja Klugewitz, Thomas Berg, Bertram Wiedenmann, Hidde L. Ploegh, Eckart Schott
Journal: Hepatology (2007)

Abstract The pathogenesis of autoimmune liver diseases is poorly understood. Animal models are necessary to investigate antigen presentation and priming of T-cells in the context of autoimmunity in the liver. Transgenic mouse models were generated in which the model antigen ovalbumin is expressed in hepatocytes (TF-OVA) or cholangiocytes (ASBT-OVA). Transgenic OT-I (CD8) or OT-II (CD4) T-cells specific for ovalbumin were adoptively transferred into TF-OVA and ASBT-OVA mice to induce in vivo priming of antigen-specific T-cells. T-cell migration and activation, as well as induction of liver inflammation, were studied. OT-I T-cells preferentially located to the liver of both mouse strains whereas no migration of OT-II T-cells to the liver was observed. OT-I T-cells proliferated in the liver of TF-OVA mice and the liver and liver draining lymph nodes of ASBT-OVA mice. OT-II CD4 T-cells were activated in spleen and liver draining lymph node of TF-OVA mice but not in ASBT-OVA mice. Transfer of OT-I T-cells led to histologically distinct inflammatory conditions in the liver of ASBT-OVA and TF-OVA mice and caused liver injury as determined by the elevation of serum alanine aminotransferase. Conclusion: An antigen expressed in hepatocytes is presented to CD8 and CD4 T-cells, whereas the same antigen expressed in cholangiocytes is presented to CD8 but not CD4 T-cells. In both models, activation of CD8 T-cells occurs within the liver and causes liver inflammation. The models presented here are valuable to investigate the priming of T-cells in the liver and their role in the development of autoimmune disease of the liver. (HEPATOLOGY 2007.)
Patients deserve more than a "Thank you"
Authors: H. M Dalal, J. Wingham, P. Evans, R. Taylor, J. Campbell
Journal: BMJ (2009)

Not only are researchers poor at acknowledging the contribution of research participants,1 we are also bad at communicating research results. Patients are rarely told about the results of studies in which they have taken part. A survey from North America reported that although 72% of clinicians thought that patients wanted to know the results of research, only 25% of them were …
Abstract LB-308: Monoubiquitination is critical for Otub1 to suppress UbcH5 and stabilize p53
Authors: Yuhunag Li, Xiao-Xin Sun, Johannes Elferich, Ujwal Shinde, Larry David, Mushui Dai
Journal: Cancer Research (2014)

Abstract Otub1 regulates p53 stability and activity via non-canonical inhibition of the MDM2 cognate ubiquitin (Ub)-conjugating enzyme (E2) UbcH5. However, it is not clear how this activity of Otub1 is regulated in cells. Here we report that Otub1 is monoubiquitinated by UbcH5 in cells and in vitro, primarily at lysine 59 and 109 residues. This monoubiquitination in turn contributes to the activity of Otub1 to suppress UbcH5. The lysine-free Otub1 mutant (Otub1K0) fails to be monoubiquitinated and is unable to suppress the Ub-conjugating activity of UbcH5 in vitro and the MDM2-mediated p53 ubiquitination in cells. Consistently, this mutant is unable to stabilize p53, induce apoptosis, and suppress cell growth. Overexpression of Otub1K0 inhibits DNA-damage induced apoptosis. Adding either Lys 59 or Lys 109 back to the Otub1K0 mutant restored the monoubiquitination of Otub1 and its function to stabilize and activate p53. We further show that UbcH5 preferentially binds to the monoubiquitinated Otub1 via Ub interaction with its backside donor Ub-interacting surface, suggesting that this binding interferes with the self-assembly of Ub-charged UbcH5 (UbcH5∼Ub) conjugates, which is critical for the Ub transfer. Thus, our data reveal novel insights into the Otub1 inhibition of E2 wherein monoubiquitination promotes the interaction of Otub1 with and its function to suppress UbcH5. Citation Format: Yuhunag Li, Xiao-Xin Sun, Johannes Elferich, Ujwal Shinde, Larry David, Mushui Dai. Monoubiquitination is critical for Otub1 to suppress UbcH5 and stabilize p53. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-308. doi:10.1158/1538-7445.AM2014-LB-308
Cholesterol induced lipid accumulation in myocardial cells of rats
Authors: S. Hexeberg, N. Willumsen, S. Rotevatn, E. Hexeberg, R. K Berge
Journal: Cardiovascular Research (1993)

Objective: The aim was to investigate whether cholesterol feeding of rats for only 10 d would result in lipid accumulation in myocardial cells and a change in the peroxisomal β oxidation in the heart compared to the hearts of rats on standard feeds. Methods: Eight rats received a cholesterol diet (2%) and eight rats received a standard diet for 10 d. Lipids were measured in serum, liver, and heart. Palmitoyl-CoA hydrolase and fatty acyl-CoA oxidase were determined in total homogenate of hearts. The fractional volume of lipid droplets in myocardial cells was calculated from micrographs at a magnification of ×9600 obtained by electron microscopy. Results: The fractional volume of lipid droplets in the cardiomyocytes increased from 0.109(SEM 0.019)% to 0.259(0.037)%, (p<0.003), as a result of cholesterol feeding. Cholesterol and triglycerides in the heart measured by biochemical methods increased by 13% and 24%, respectively. There was no difference in palmitoyl-CoA hydrolase or fatty acyl-CoA oxidase in the hearts of the cholesterol fed group compared to the control group, suggesting an unaltered peroxisomal β oxidation of fatty acids in the myocardium. The serum triglycerides and serum phospholipids were reduced in the cholesterol fed rats (p<0.05 and p<0.001, respectively). Rats fed cholesterol diet showed a reduced ratio of HDL cholesterol to total cholesterol in serum, together with an increased liver weight and relative liver weight compared to the control rats. The addition of cholesterol to the diet increased liver cholesterol to 21.0(1.6) μmol·g−1 wet weight compared to 5.87(0.93) μmol·g−1 in the controls on standard diet (p<0.0001). Cholesterol feeding had no effect on the hepatic level of phospholipids, but the liver triglycerides tended to increase from 23.3(9.5) μmol·g−1 wet weight to 53.3(6.3) μmol·g−1. Conclusions: Lipid accumulation in the myocardial cells was shown by morphometry after 10 d of cholesterol feeding, without any visible damage to the tissue. Cardiovascular Research 1993;27:442-446
Skin DCs go deeper
Authors: Richard Robinson
Journal: The Journal of Experimental Medicine (2007)

Vol. 204, No. 13, December 17, 2007. Pages [3054–3055][1].

Please note that the story inaccurately attributed the observation of dendritic cells in the lung and liver to Poulin et al. This discovery was in fact made by Bursch et al. The html and pdf versions have been corrected.

 [1]: /lookup/
Immune response modifiers in the treatment of asthma: A PRACTALL document of the American Academy of Allergy, Asthma &amp; Immunology and the European Academy of Allergy and Clinical Immunology
Authors: Mark Ballow, Cezmi A. Akdis, Thomas B. Casale, Andrew J. Wardlaw, Sally E. Wenzel, Zuhair Ballas, Jan Lötvall
Journal: Journal of Allergy and Clinical Immunology (2012)
The Science of Limitations
Authors: James A. Scott
Journal: JAMA (1981)

We shall know a little more than we do now. But the real nature of things, that we shall never know, never.<sup>1</sup> In the view of many scientists today, this seems a rather pessimistic prediction. We know much more than we did 20 years ago, and the most naive extrapolation suggests that we will know much more in another 20 years than we do now. Developments in science have so far outraced those in the humanistic fields that many people, perhaps especially scientists, expect that science itself will provide the answers to many of our current sociological problems. Of all areas of scientific research, the biomedical field has emerged at the forefront in the last two decades. From mechanical descriptions of organ function we have refocused our attention to the smallest constituents of the living cell, and this in the hope that what can be observed with the eye
OPEN-AIR TREATMENT FOR WOUNDS: A Simple and Inexpensive Form of Open-Air Ward, as used at the V.A.D. Hospital, Henley-in-Arden
Authors: W. E. Nelson
Journal: BMJ (1915)

Iproiotes lealinig, for it is usually possible at the same tim-ie to take awvay fragments of cloth, which are such a potent cause of prolonged suppuration.The adoption of
Dilemma of Implant Surgery
Authors: G. K. McKee
Journal: BMJ (1960)

<b>Introduction:</b> Many people think that once a sputum positive patient is started on antitubercular drug, he is not in infective phase. In order to consider whether the patient is in non infective or sputum AFB follow up is needed. Sputum Culture negative conversion rate after 2 months of anti-TB treatment -a reliable surrogate marker for relapse after treatment. In MDR patients early conversion to negative suggests better treatment outcomes. <b>AIMS:</b> To find out average time for sputum culture negative conversion and number of MDR converting into XDR. <b>Methodology:</b> Retrospective study of 89 Drug Resistant TB patients diagnosed with culture-proven pulmonary and extrapumonary TB treated under DOTS Plus in our hospital from January to December 2015. Patients were classified according to the drug resistance pattern into MDR and XDR.From them subdivided into pulmonary and extrapulmonary. Patients under 12 years were excluded in the study. <b>Results:</b> In 89 patients 67 had MDR and 12 had XDR Sputum conversion rates to negative were maximum during 3 months in both drug resistant tuberculosis groups with MDR and XDR, 46.8% and 66.7% respectively <b>Conclusion:</b> Not every Drug Resistant TB patient will be sputum converted in first three months and chance of reconverting to positive in further follow up is also seen. From this study patients are in infective stage until maximum of 9 months. Thus patients have to take special care and wear N95 masks to prevent spread of the infection to the society. REFERENCES: Telzac EE et al. Factors influencing time to sputum conversion among patients with smear positive pulmonary tuberculosis, Clinn infect Dis, 1997, vol.25(pg 666-70)
The American Geriatrics Society
Authors: Brock E. Brush
Journal: JAMA (1965)

<h3>To the Editor:—</h3> For many years, we have had trouble due to the confusion concerning the independently owned<i>Geriatrics</i>, published in Minneapolis. Some of our members subscribe to this independent journal and, by so doing, feel that they have paid their dues to the society. We have had many letters to this effect. To dispel this widespread misunderstanding, we must state that our society has no connection whatsoever with the privately owned journal<i>Geriatrics</i>. The only official journal of our society is the<i>Journal of the American Geriatrics Society</i>. It is owned by the society, and edited and managed by physician members. Our journal is a nonprofit service to our members. Our journal is the most outstanding in the field of geriatric medicine. The National Library of Medicine subscribes to 37,000 medical journals published throughout the world. A survey conducted by this library on the loan-demand for reference purposes showed
Edema and Hemolytic Anemia in Premature Infants
Authors: Joshua H. Ritchie, Mathews B. Fish, Virginia McMasters, Moses Grossman
Journal: New England Journal of Medicine (1968)

Widespread edema, anemia, reticulocytosis, thrombocytosis and vitamin E deficiency were noted in seven premature infants during the second month of life. Appropriate studies excluded the usual causes of these findings. The erythrocyte survival times, measured by means of DF32P and 51Cr, were strikingly short, confirming the hemolytic nature of the anemia. All infants had been fed commercial formulas with iron and a high content of polyunsaturated fatty acid, resulting in a low ratio of vitamin E to fatty acids. When vitamin E (alpha-tocopherol acetate), 75 to 100 IU daily, was given separately by mouth to five infants available for treatment and study, serum tocopherol level rose, reticulocyte count fell to normal and erythrocyte survival time lengthened; this was followed by correction of the anemia, clearing of the edema and subsidence of the thrombocytosis. Formulas having low ratios of vitamin E to polyunsaturated fatty acids and added iron supply, an inadequate amount of vitamin E to low-birth-weight infants, in whom vitamin E deficiency may be a common and important cause of anemia and edema.
Type I Diabetes Mellitus in Monozygotic Twins: Chronic Progressive Beta Cell Dysfunction
Authors: S. SRIKANTA
Journal: Annals of Internal Medicine (1983)

In a prospective 21-year study, islet cell antibodies and beta cell function were serially assessed in 24 monozygotic twins initially discordant for type I diabetes mellitus. Eighteen of 21 twins typed had HLA-DR3 or HLA-DR4 antigens. During the follow-up, 4 twins developed type I diabetes mellitus, and in 3 of these 4 twins islet cell antibodies preceded the diagnosis of clinical diabetes mellitus by greater than 8, 5 and 7 years respectively. During the "prediabetic phase," the presence of islet cell antibodies was temporally associated with a progressive decline in first phase insulin response to intravenous glucose. Elevations in fasting blood glucose and abnormalities on oral glucose tolerance tests appeared only later during the course of the disease. Of the remaining 20 twins who continue to be discordant for type I diabetes mellitus, two have had islet cell antibodies for greater than 1.5 and 1 year respectively. One of these islet cell antibody-positive non-diabetic twins was restudied; despite a fasting blood glucose level of 64 mg/dL, she had a total absence of first phase insulin response to intravenous glucose. There was no evidence of transient islet cell antibody positivity in any of the twins studied. Type I diabetes mellitus in monozygotic twins has a prolonged prediabetic phase of progressive beta cell dysfunction with associated immunologic abnormalities.
Tazarotene gel, a new retinoid, for topical therapy of psoriasis: Vehicle-controlled study of safety, efficacy, and duration of therapeutic effect
Authors: Gerald D. Weinstein, Gerald G. Krueger, Nicholas J. Lowe, Madeleine Duvic, David J. Friedman, Brian V. Jegasothy, Joseph L. Jorizzo, Edward Shmunes, Eduardo H. Tschen, Deborah A. Lew-Kaya, John C. Lue, John Sefton, John R. Gibson, Roshantha A.S. Chandraratna
Journal: Journal of the American Academy of Dermatology (1997)
Health-Related Quality of Life and Symptom Management Research Sponsored by the National Cancer Institute
Authors: Lori M. Minasian, Ann M. O'Mara, Bryce B. Reeve, Andrea M. Denicoff, Joseph Kelaghan, Julia H. Rowland, Edward L. Trimble
Journal: Journal of Clinical Oncology (2007)

For almost 30 years, the National Cancer Institute (NCI) has sponsored health-related quality-of-life (HRQOL) measures in cancer research as a means of including the patient's experience. The scope of NCI's research in symptom management and HRQOL is described with attention to its evolution over time and the next steps, through the Clinical Trials Working Group Recommendations.
Crohn's disease and carcinoma of colon.
Authors: R. Wyburn-Mason
Journal: BMJ (1968)

mention of asbestos-like bodies in describing the effects in the lung of inhaled glass wool fibres in two animal species, including a species which consistently forms asbestos bodies when exposed to asbestos dust.There are few reports in the literature on the effects of glass fibre in man, but Murphy,5 in a human case of " fibre-glass pneumoconiosis,"
TCT-274 Relationship Between Arterial Remodeling, Fibrous Cap Thinning and Lipid Accumulation: A Serial Integrated Backscatter Intravascular Ultrasound and Optical Coherence Tomography Study
Authors: Teruyoshi Kume, Hiroyuki Okura, Kenzo Fukuhara, Yoshinori Miyamoto, Shintaro Nezuo, Yoji Neishi, Akihiro Hayashida, Takahiro Kawamoto, Kiyoshi Yoshida
Journal: Journal of the American College of Cardiology (2012)
A NEW INSTRUMENT FOR CLOSING ABDOMINAL WOUNDS
Authors: A. H. Rosburg
Journal: JAMA (1926)

This device is made of two brass rods and two or more (depending on the length of the ladder) cross wires or steps of the ladder. The entire device is nickeled. The rods, or uprights, of the ladder are from 2 to 12 inches long and three-eighths inch in diameter. The steps, or cross bars, are 2½ inches long, and slightly curved.The device does away with the heavy chromic catgut sutures usually placed in the anterior sheath of the rectus, and incidently with a lot of postoperative wound infections; it absolutely prevents cutting of the skin by the tension sutures; it compresses the tissues of the abdominal wall and thus does away with dead space. The device is placed on the part to be incised, and with the back of the blade of the scalpel two parallel marks are made on the skin just lateral to the uprights
Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels
Authors: Peter Clarkson, David S. Celermajer, Ann E. Donald, Mike Sampson, Keld E. Sorensen, Mark Adams, Dennis K. Yue, D. John Betteridge, John E. Deanfield
Journal: Journal of the American College of Cardiology (1996)
Left Bundle Branch Block Predicts Better Survival in Women Than Men Receiving Cardiac Resynchronization Therapy
Authors: Zak Loring, Daniel A. Caños, Kimberly Selzman, Naomi D. Herz, Henry Silverman, Thomas E. MaCurdy, Christopher M. Worrall, Jeffrey Kelman, Mary E. Ritchey, Ileana L. Piña, David G. Strauss
Journal: JACC Heart Failure (2013)