tbuckley/cabot-search huggingface dataset:
Late Development of Systemic Lupus Erythematosus in Patients with Glomerular "Fingerprint" Deposits
Authors: CHARLES E. ALPERS
Journal: Annals of Internal Medicine (1984)

Two patients presenting with nephrotic syndrom but without evidence of collagen vascular disease had organized glomerular immune deposits with a "fingerprint" pattern. This finding has been previously associated with lupus nephritis and, in our institution, has been seen in 6% of the biopsy specimens from patients with lupus nephritis. Clinical signs and symptoms of systemic lupus erythematosus in these two patients did not develop until 2 and 5 years later, respectively. The cases of these patients suggest that glomerular deposits with a fingerprint pattern may be a specific marker for lupus erythematosus even when overt clinical features of this disease are lacking. Patients with this finding on renal biopsy should have an extended follow-up for possible development of lupus erythematosus.
Antifungal effect and possible mode of activity of a compound from the marine sponge Dysidea herbacea
Authors: Edward Sionov, Dalit Roth, Hana Sandovsky-Losica, Yoel Kashman, Amira Rudi, Liat Chill, Israela Berdicevsky, Esther Segal
Journal: Journal of Infection (2004)
Cost-Effectiveness of Nurse-Led Disease Management for Heart Failure in an Ethnically Diverse Urban Community
Authors: Paul L. Hebert, Jane E. Sisk, Jason J. Wang, Leah Tuzzio, Jodi M. Casabianca, Mark R. Chassin, Carol Horowitz, Mary Ann McLaughlin
Journal: Annals of Internal Medicine (2008)

Randomized, controlled trials have shown that nurse-led disease management for patients with heart failure can reduce hospitalizations. Less is known about the cost-effectiveness of these interventions.To estimate the cost-effectiveness of a nurse-led disease management intervention over 12 months, implemented in a randomized, controlled effectiveness trial.Cost-effectiveness analysis conducted alongside a randomized trial.Medical costs from administrative records, and self-reported quality of life and nonmedical costs from patient surveys.Patients with systolic dysfunction recruited from ambulatory clinics in Harlem, New York.12 months.Societal and payer.12-month program that involved 1 face-to-face encounter with a nurse and regular telephone follow-up.Quality of life as measured by the Health Utilities Index Mark 3 and EuroQol-5D and cost-effectiveness as measured by the incremental cost-effectiveness ratio (ICER).Costs and quality of life were higher in the nurse-managed group than the usual care group. The ICERs over 12 months were $17,543 per EuroQol-5D-based quality-adjusted life-year (QALY) and $15,169 per Health Utilities Index Mark 3-based QALY (in 2001 U.S. dollars).From a payer perspective, the ICER ranged from $3673 to $4495 per QALY. Applying national prices in place of New York City prices yielded a societal ICER of $13,460 to $15,556 per QALY. Cost-effectiveness acceptability curves suggest that the intervention was most likely cost-effective for patients with less severe (New York Heart Association classes I to II) heart failure.The trial was conducted in an ethnically diverse, inner-city neighborhood; thus, results may not be generalizable to other communities.Over 12 months, the nurse-led disease management program was a reasonably cost-effective way to reduce the burden of heart failure in this community.
Oxygen Consumption of the Completely Isolated Dog Heart In Fibrillation
Authors: OLEG JARDETZKY, ERNEST A. GREENE, VICTOR LORBER
Journal: Circulation Research (1956)

Evidence is presented, that in the completely isolated nonworking dog heart oxygen consumption is higher during a period of electrically induced fibrillation than during a period of rhythmical contraction and that this increase is not due to the electric stimulus per se.
Mechanisms of tubulointerstitial fibrosis
Authors: Gerald S. Kuncio, Eric G. Neilson, Thomas Haverty
Journal: Kidney International (1991)

With regard to tubulointerstitial fibrogenesis we are left with a variety informational gaps regarding nearly all aspects of this clinically important process. Table 2 summarizes a generalized version of fibrogenesis based primarily on investigations in other organs. Extrapolation of data obtained with other fibrogenic systems is useful, but only in so far as it motivates us to adapt and test many of the experimental principles within in the context of the kidney. This begins with a comprehensive examination of the in vivo state, the establishment of adequate animal models, and the dissections of the process in vitro. Key areas for the future are the characterization of the signals involved, the cellular responses to these signals, and the variations in interactions produced by differing inciting fibrogenic conditions.
Ex vivo purging of leukemia cells using tumor-necrosis-factor-related apoptosis-inducing ligand in hematopoietic stem cell transplantation
Authors: N-S Lee, H-J Cheong, S-J Kim, S-E Kim, C-K Kim, K-T Lee, S-K Park, S-H Baick, D-S Hong, H-S Park, J-H Won
Journal: Leukemia (2003)
Washington Matthews, M.D., the Navajo Years
Authors: John Porvaznik
Journal: New England Journal of Medicine (1977)

The year was 1880. Just 16 years earlier the Navajo Tribe had been defeated, and some 8000 men, women and children were force-marched 640 km across New Mexico Territory to their prison reservation at Fort Sumner. Here, the government attempted to turn these roaming, pastoral people into settled farmers. By the end of four years, this experiment was recognized as a failure, and the Navajo were allowed to return to their homeland in northern Arizona-New Mexico. In this year of 1880, when the Navajo People were struggling to recapture their former lives and traditions, Dr. Washington Matthews was assigned to . . .
Ethyl Chlorid As a General Anesthetic in Minor Operations.
Authors: Maurice Green
Journal: JAMA (1906)

New York, Aug. 22, 1906. <h3>To the Editor:</h3> —I noticed an article with the above title inThe Journal, August 18, by George F. Hawley, M.D. I desire to call attention to the fact that the inhaler referred to was devised by me for ethyl chlorid narcosis, and has been used by the medical and dental professions for at least three years. He appends the name of "Apperson" to the inhaler, when it is and should be called the antidolorin inhaler, devised by Maurice Green, D.D.S. No doubt Dr. Hawley has been misinformed or misled, and in proof of my statement I enclose reprints of several articles I have written in the past on this subject, in which are cuts identical to the one used by him. I do not look for any special credit as the inventor of this device, but I do object to any one taking undeserved
Physician Use of Marijuana, Alcohol, and Tobacco
Authors: MARTIN R. LIPP, SAMUEL G. BENSON
Journal: American Journal of Psychiatry (1972)

The authors questioned 1,314 physicians (chosen at random from four geographical areas) concerning their use of and opinions about marijuana. Thirty-seven percent had been exposed to marijuana, 25 percent had used it, and seven percent were using it currently. In general, experience with cannabis varied with age and location. When queried about their use of alcohol and cigarettes, only eight percent of the subjects were teetotalers and 21 percent currently smoked cigarettes.
The Mortality of Elder Mistreatment
Authors: Mark S. Lachs
Journal: JAMA (1998)

Context.-Although elder mistreatment is suspected to be life threatening in some instances, little is known about the survival of elderly persons who have been mistreated.Objective.-Toestimate the independent contribution of reported elder abuse and neglect to all-cause mortality in an observational cohort of community-dwelling older adults.Design.-Prospective cohort study with at least 9 years of follow-up.Setting and Patients.-TheNew Haven Established Population for Epidemiologic Studies in the Elderly cohort, which included 2812 community-dwelling adults who were older than 65 years in 1982, a subset of whom were referred to protective services for the elderly.Main Outcome Measures.-All-causemortality among (1) elderly persons for whom protective services were used for corroborated elder mistreatment (elder abuse, neglect, and/or exploitation), or (2) elderly persons for whom protective services were used for self-neglect.Results.-In the first 9 years after cohort inception, 176 cohort members were seen by elderly protective services for verified allegations; 10 (5.7%) of these were for abuse, 30 (17.0%) for neglect, 8 (4.5%) for exploitation, and 128 (72.7%) for self-neglect.At the end of a 13-year follow-up period from cohort inception, cohort members seen for elder mistreatment at any time during the follow-up had poorer survival (9%) than either those seen for self-neglect (17%) or other noninvestigated cohort members (40%) (PϽ.001).In a pooled logistic regression that adjusted for demographic characteristics, chronic diseases, functional status, social networks, cognitive status, and depressive symptomatology, the risk of death remained elevated for cohort members experiencing either elder mistreatment (odds ratio, 3.1; 95% confidence interval, 1.4-6.7)or self-neglect (odds ratio, 1.7; 95% confidence interval, 1.2-2.5),when compared with other members of the cohort.Conclusions.-Reported and corroborated elder mistreatment and self-neglect are associated with shorter survival after adjusting for other factors associated with increased mortality in older adults.
ABC of clinical electrocardiography: Atrial arrhythmias
Authors: S. Goodacre
Journal: BMJ (2002)

<h3>Abstract</h3> The capacity to precisely modulate aptamer affinity is important for a wide variety of applications, including biosensing, drug delivery, nanodevices, and gene expression. However, most such engineering strategies entail laborious trial-and-error testing or require prior knowledge of an aptamer’s structure and ligand-binding domain. We describe here a simple and generalizable strategy for achieving allosteric modulation of aptamer affinity by employing a molecular clamp system that destabilizes aptamer secondary structure. We flank the aptamer sequence with ‘tuning clamp domain’ sequences, which hybridize to an allosteric inhibitor DNA strand. The double-stranded molecular clamp introduces mechanical tension that reduces the aptamer’s affinity for the ligand, where the extent of this affinity modulation can be reliably modelled to guide optimal molecular clamp design. We demonstrate the effectiveness of this approach with a thrombin-binding aptamer, HD22, and show that we can reduce the affinity of the aptamer by as much as 65-fold using our molecular clamp system. We also show that this modulation can be rendered reversible by introducing a restriction enzyme cleavage site into the molecular clamp domain and describe a design strategy for achieving even more finely-tuned affinity modulation. This strategy requires no prior knowledge of the aptamer’s structure and binding mechanism and should thus be generalizable across aptamers.
Fraudulent Studies and Meta-analysis
Authors: Jeffery Sobal
Journal: JAMA (1988)

To the Editor.—  Recently Dr Thacker 1 and others 2 have discussed meta-analysis as a powerful method for quantitatively analyzing existing research to provide insights not available from individual studies or less rigorous summaries of research findings. Because the quality of a meta-analysis depends on the inclusion of a large sample of welldone studies, a major threat to the validity of meta-analysis is the existence of fraudulent or erroneous published research. While research fraud may be rare, concentration of an investigator's fraudulent articles in one area can present a severe bias in meta-analysis. In recent cases, Slutsky published 60 articles, 12 of which were fraudulent and 48 suspect, 3 with six on one topic retracted from one journal 4 ; Darsee published 129 related articles suspected of fraudulence. 5   Fraudulent articles obviously should be excluded from meta-analyses because they erroneously increase pooled sample size. They may change the results of a
Editorial position on publishing articles on human organ transplantation
Authors: Arthur L. Caplan, Howard A. Rockman, Laurence A. Turka
Journal: Journal of Clinical Investigation (2012)

The practice of transplanting organs from executed prisoners in China appears to be widespread. We vigorously condemn this practice and, effective immediately, will not consider manuscripts on human organ transplantation for publication unless appropriate non-coerced consent of the donor is provided and substantiated.
Sodium Depletion Related to Hydrotherapy for Burn Injury
Authors: Robert A. Gotshall
Journal: JAMA (1968)

Severe sodium depletion occurred in association with treatment of burn injury by repeated submersion in water. There was associated azotemia and loss of potassium and extracellular volume. The abnormalities were promptly reversed with replacement therapy. A primary loss of electrolyte through the burned surface into the whirlpoolbath water is postulated.
Ventricular Tachycardia Associated with Trastuzumab
Authors: Charles Ferguson, Jacqueline Clarke, Niall A. Herity
Journal: New England Journal of Medicine (2006)

To the Editor: In August 2005, the Food and Drug Administration and Genentech issued warnings to physicians about cardiotoxicity associated with the monoclonal antibody trastuzumab (Herceptin), as ...
Legionnaires' Disease Antigen Detected by Enzyme-Linked Immunosorbent Assay
Authors: RICHARD C. TILTON
Journal: Annals of Internal Medicine (1979)

An enzyme-linked immunosorbent assay method has been developed for the rapid detection of antigen from clinical specimens such as urine and sputum. Preliminary evidence suggests that the antigen is present and can be detected in the sputum and possibly urine of patients with Legionnaires' disease. Patients not harboring the Legionnaires' disease bacterium have been uniformly negative to date.
HTLV-III, AIDS, and the Brain
Authors: Paul H. Black
Journal: New England Journal of Medicine (1985)

Two timely and important articles in this issue of the Journal deal with infection of the central nervous system by the human T-cell lymphotropic virus Type III (HTLV-III). The article by Ho et al.1 indicates that acute infection of the central nervous system occurs with seroconversion to the HTLV-III agent. This study further indicates that certain patients with HTLV-III infection have had neurologic disease but no clinical manifestations of immunodeficiency, although this needs more precise documentation. The article by Resnick et al.2 documents the presence within the blood–brain barrier of a specific immunoglobulin to HTLV-III in patients with neurologic complications . . .
Early budesonide treatment in mild persistent asthma improves asthma control
Authors: G Rohde
Journal: Thorax (2003)

▴ Pauwels RA, Pedersen S, Busse WW, et al on behalf of the START Investigators Group. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet2003;361:1071–6 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] In this randomised, double blind, 3 year clinical trial the effects of budesonide in patients with mild persistent asthma for less than 2 years were assessed. 7241 patients in 32 countries aged 5–66 years received either budesonide or placebo once … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DPauwels%26rft.auinit1%253DR.%2BA.%26rft.volume%253D361%26rft.issue%253D9363%26rft.spage%253D1071%26rft.epage%253D1076%26rft.atitle%253DEarly%2Bintervention%2Bwith%2Bbudesonide%2Bin%2Bmild%2Bpersistent%2Basthma%253A%2Ba%2Brandomised%252C%2Bdouble-blind%2Btrial.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252803%252912891-7%26rft_id%253Dinfo%253Apmid%252F12672309%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(03)12891-7&link_type=DOI [3]: /lookup/external-ref?access_num=12672309&link_type=MED&atom=%2Fthoraxjnl%2F58%2F6%2F536.atom [4]: /lookup/external-ref?access_num=000181865200007&link_type=ISI
Localization of the gene for familial hypertrophic cardiomyopathy to chromosome 14q1 in a diverse American population
Authors: J.Fielding Hejtmancik, Paul A. Brink, Jeffrey Towbin, Rita Hill, Lucy Brink, Grazyna Z Czemuszewicz, Terry Tapscott, Anatole Trakhtenbrolt, M.Benjamin Perryman, Robert Roberts
Journal: Journal of the American College of Cardiology (1991)
Open, Comminuted Fracture of the Distal Humerus
Authors: Otto E. Aufranc
Journal: JAMA (1968)

Dr. Mohinder Mital: An 81-year-old widow arrived in the emergency ward of the Massachusetts General Hospital with a chief complaint of pain in the right arm. She described a fall down one flight of stairs approximately one hour before admission. There was no loss of consciousness preceding or following the injury. Her past medical history included fractures of the mid shafts of the right radius and ulna nine years earlier. These had been treated by open reduction with Rush rod fixation of the ulna and iliac crest bone graft fixation of the radius, held in position by four stainless steel screws. A clinic note one year after this injury described no symptoms and a full range of flexion and extension of the elbow with 30° pronation and 50° supination in the forearm. Physical examination revealed an alert, elderly, obese woman. She was complaining bitterly of pain in the right arm.
Pressure at Catheter Tip In Selective Angiography
Authors: David B. Gilbert
Journal: JAMA (1967)

To the Editor:—  Delivery Pressure at the Catheter Tip in Selective Angiography by Lim and Cadwallader ( 199 :11, 1967) presents interesting quantitative observations on an in vitro model. In that those conclusions carry strong implications, the following comments are presented.   The frequency response of the pressure transducer was not given. This prevents a complete appraisal of the delivery pressure curve, specifically the oscillations in the early portion of the curves. The time scale in these curves is missing.  The outflow orifice size and relative geometric configuration are not explicitly shown; both will be intimately related to the transient response of the delivery pressure. As an example, were the outflow orifice 3 cm in diameter, one would not expect as sharp a peak nor as constant a plateau during injection. Also, the transient response will be very closely related to the pliability of the enclosure's walls. One would not
Phlegm and Filters
Authors: J. Rimington
Journal: BMJ (1972)

Male mass radiography volunteers aged 40 or more were questioned about their sputum production and cigarette consumption in relation to type (filter or plain) smoked. Of 10,414 volunteers, 3,045 smoked filter cigarettes and 2,393 smoked plain cigarettes. The rate of persistent daily sputum of filter smokers (31.9%) was significantly lower than that of plain cigarette smokers (37.2%). A similar pattern was maintained when age and cigarette consumption were standardized. These figures are thought to understate the less injurious nature of filter cigarettes, since more than half of the filter smokers with persistent sputum developed this while previously smoking plain cigarettes.Whatever the reasons for the less injurious nature of filter cigarettes, it seems that cigarette smokers unable to stop smoking might suffer less from chronic bronchitis if they changed to filter cigarettes.
Sepsis and hyperoxia effects on the pulmonary surfactant system in wild-type and iNOS knockout mice
Authors: T.C. Bailey, C. Cavanagh, S. Mehta, J.F. Lewis, R.A.W. Veldhuizen
Journal: European Respiratory Journal (2002)

Alterations of pulmonary surfactant and increases in inducible nitric oxide synthase (iNOS) have been implicated in the pathophysiology of acute lung injury. It was hypothesised that these two observations are related and that alterations of the endogenous surfactant, due to either sepsis or hyperoxia, would be reduced in mice lacking the iNOS gene compared to wild-type mice. Wild-type and iNOS (−/−) mice were randomised into sham or sepsis, and in a separate experiment animals were randomised to normoxia or hyperoxia exposure for 48 h. Lungs were lavaged and analysed for total surfactant levels and surfactant subfractions (large (LA) and small (SA) aggregates). Both sepsis groups had decreased SA compared to sham groups with no significant difference between the two genotypes. Mice exposed to hyperoxia had a decreased amount of total surfactant when compared to normoxia controls and there was no significant difference between the two genotypes. It is concluded that inducible nitric oxide synthase does not influence the amount of pulmonary surfactant or surfactant subfractions recovered in lavage after 18 h of sepsis or 48 h of hyperoxia.
Nuclear receptors take center stage in Th17 cell–mediated autoimmunity
Authors: Jennifer J. Heller, Ju Qiu, Liang Zhou
Journal: Journal of Clinical Investigation (2011)

Liver X receptors (LXRs) are nuclear receptors involved in cholesterol homeostasis. Notably, they are also expressed by T cells and are involved in regulating T cell proliferation and differentiation. In this issue of the JCI, Cui et al. have elucidated the molecular mechanism underlying the effects of LXR activation on a subset of T cells known as Th17 cells in mice and humans. Specifically, they showed that LXR-induced Srebp-1 inhibits Il17 transcription by binding to the Il17 promoter through interaction with the aryl hydrocarbon receptor (Ahr), a transcription factor known to enhance Th17 cell responses.