tbuckley/cabot-search huggingface dataset:
Abstract B22: Beta-arrestin2-CARMA3 signaling axis plays critical roles in lysophosphatidic acid-induced ovarian cancer migration and invasion
Authors: Jiyuan Sun, Jingli Cai, Feng Yumei
Journal: Clinical Cancer Research (2010)

Abstract Ovarian cancer is ranked as the 4th most common type of cancer among women in the United States. Lysophosphatidic acid (LPA) is the diagnostic marker of ovarian cancer. It is significantly elevated in 90% of ovarian cancer patients. Moreover, LPA receptors are aberrantly up-regulated in ovarian cancer patients. LPA is a type of G protein-coupled receptor ligand. In our previous studies, we have demonstrated that a signaling axis consisting of beta-arrestin 2 and CARMA3 (CARD and MAGUK domain-containing protein 3) is required in LPA-induced nuclear factor kappa B (NF-κB) activation in mouse embryonic fibroblast cells. NF-κB is an important transcription factor, which has been proven to mediate LPA-induced ovarian cancer migration and invasion. In this study, we further investigated whether the beta-arrestin2-CARMA3 signaling axis plays a significant role in LPA-induced ovarian cancer cell migration and invasion. Using beta-arrestin 2 and CARMA3 shRNA, we knockdowned their protein expression levels in ovarian cancer cell lines. Consistent with previous reports, we found that down-regulation of beta-arrestin 2 and CARMA3 abolished LPA-induced IKK activity and NF-κB activation in ovarian cancer cells. In addition, in vitro transwell migration and matrigel invasion assays demonstrated that beta-arrestin 2 and CARMA3 shRNA significantly impaired LPA-induced ovarian cancer cell motility and invasiveness. Together, our results provide the evidence that beta-arrestin 2 and CARMA3 serve as critical regulators in LPA-induced, NF-κB-mediated ovarian cancer migration and invasion. Therefore, we speculate that beta-arrestin 2 and CARMA3 may represent attractive therapeutic targets for ovarian cancer and many other types of malignancies. Citation Information: Clin Cancer Res 2010;16(7 Suppl):B22
Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality
Authors: Yaping Sun, Sooryanarayana Varambally, Christopher A. Maher, Qi Cao, Peter Chockley, Tomomi Toubai, Chelsea Malter, Evelyn Nieves, Isao Tawara, Yongqing Wang, Peter A. Ward, Arul Chinnaiyan, Pavan Reddy
Journal: Blood (2011)
Rapid diagnosis of cryptococcosis using an antigen detection immunochromatographic test
Authors: Diane Rivet-Dañon, Juliette Guitard, Frédéric Grenouillet, Frédérick Gay, Nawel Ait-Ammar, Adela Angoulvant, Carine Marinach, Christophe Hennequin
Journal: Journal of Infection (2015)
Atlas of General Surgical Techniques
Authors: Daniel J. Kacey
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Posture on Glucose Tolerance after Gastric Surgery
Authors: C. D. Holdsworth, I. Hulme-Moir, C. Thirumalai
Journal: BMJ (1972)

Oral glucose tolerance after either partial gastrectomy or vagotomy and pyloroplasty for duodenal ulcer was markedly affected by posture. Peak blood glucoses and the degree of reactive hypoglycaemia were greater in the erect than in the supine position. This is probably due to positional changes in gastric emptying, and our findings support the view that after gastric surgery alteration in gastric emptying rate is the main factor responsible for the change in oral glucose tolerance.
Cancer of the Digestive Tract: Clinical Management
Authors: John H. Wulsin
Journal: JAMA (1970)

This effective volume, written by surgeons, encompasses the presentday clinical understanding of cancer of the digestive tract, which, as the editors state in the preface, claims more victims (an estimated 98,300 in 1969) than cancer of any other system. The editors, both eminent authorities in the field of cancer, have called on various surgical experts to discuss carcinoma in particular segments of the gastrointestinal tract, from esophagus to anus, and including the pancreas, liver, and extrahepatic system. Dr. Cole contributed the chapter on carcinoma of the colon and Dr. Everson two chapters on carcinoma of the stomach and small intestine. An interesting chapter discusses carcinoids and the physiology of their chemical products. For sake of completeness, radiation therapy and chemotherapy receive nominal space at the end of the volume. For the practitioner this information would be more useful if woven into the discussions dealing with specific treatment of lesions. The
Endocrine disruptors and human health--is there a problem? An update.
Authors: S H Safe
Journal: Environmental Health Perspectives (2000)

It has been hypothesized that environmental exposure to synthetic estrogenic chemicals and related endocrine-active compounds may be responsible for a global decrease in sperm counts, decreased male reproductive capacity, and breast cancer in women. Results of recent studies show that there are large demographic variations in sperm counts within countries or regions, and analyses of North American data show that sperm counts have not decreased over the last 60 years. Analyses of records for hypospadias and cryptorchidism also show demographic differences in these disorders before 1985; however, since 1985 rates of hypospadias have not changed and cryptorchidism has actually declined. Temporal changes in sex ratios and fertility are minimal, whereas testicular cancer is increasing in most countries; however, in Scandinavia, the difference between high (Denmark) and low (Finland) incidence areas are not well understood and are unlikely to be correlated with differences in exposure to synthetic industrial chemicals. Results from studies on organochlorine contaminants (DDE/PCB) show that levels were not significantly different in breast cancer patients versus controls. Thus, many of the male and female reproductive tract problems linked to the endocrine-disruptor hypothesis have not increased and are not correlated with synthetic industrial contaminants. This does not exclude an endocrine-etiology for some adverse environmental effects or human problems associated with high exposures to some chemicals.
Ortner Syndrome Associated With Aortic Pseudoaneurysm After Repair of Aortic Coarctation 30 Years Previously
Authors: Naoto Fukunaga, Tadaaki Koyama, Yasunobu Konishi, Takashi Murashita, Mitsuru Yuzaki, Yu Shomura, Hiroshi Fujiwara, Yukikatsu Okada
Journal: Circulation (2012)
Mediterranean Diet Inversely Associated With the Incidence of Metabolic Syndrome
Authors: Arancha Tortosa, Maira Bes-Rastrollo, Almudena Sanchez-Villegas, Francisco Javier Basterra-Gortari, Jorge Maria Nuñez-Cordoba, Miguel A. Martinez-Gonzalez
Journal: Diabetes Care (2007)

There is some evidence of the beneficial role of food patterns and lifestyles on metabolic syndrome (1,2). The Mediterranean food pattern (MFP) has acquired an emerging role in cardiovascular epidemiology (3). It is characterized by a high consumption of fruits, vegetables, legumes, grains, moderate alcohol intake, a moderate-to-low consumption of dairy products and meats/meat products, and a high monounsaturated–to–saturated fat ratio. Although some cross-sectional studies have suggested that the MFP (or some of its components) may reduce the incidence of the metabolic syndrome (1,4), there are no prospective studies assessing this association.

Our aim was to prospectively assess the relationship between adherence to the MFP and the subsequent development of metabolic syndrome in the Seguimiento Universidad de Navarra (SUN) dynamic cohort, composed of Spanish university graduates followed up for 6 years (5).

The SUN Study uses methodology similar to that of large American cohorts (6), but recruitment is permanently open (it is designed as a dynamic cohort). Baseline assessment of participants consists of a self-administered questionnaire sent by postal mail, gathering information on lifestyle factors and including a 136-item validated food frequency questionnaire (7). Biennially mailed follow-up questionnaires are used to collect a wide variety of information about diet, lifestyle, and medical conditions (5).

Among the 18,000 graduates currently participating in the SUN cohort, 5,360 members were recruited …
LEUKEMIA.REPORT OF A CASE SYMPTOMATICALLY CURED BY THE X-RAY.
Authors: EVERETT J. BROWN
Journal: JAMA (1904)

<h3>Introduction.</h3> —A case of splenomedullary leukemia successfully treated by the use of the Roentgen ray is reported by Senn.<sup>1</sup>In looking up the literature at my disposal, which includes the<i>Index Medicus</i>, I fail to find any further reports of cases thus treated. At the time of the appearance of Senn's report, the patient, whose history I give below, had been under<i>x</i>-ray treatment for seven weeks. From the time of the first recognition of this disease a fatal termination has always been expected, yet it is known that occasionally recovery occurs, or there is an apparent arrest, either spontaneously, or after the use of arsenic; hence in recording the effect of any treatment of leukemia the word "cure" must be used with caution. Although an examination of my patient to-day would show an entire absence of every symptom of the disease, both by physical and blood examination
SPONTANEOUS VENOUS THROMBOSIS IN THE LEGS OF TALL MEN
Authors: Meyer Naide
Journal: JAMA (1952)

A dangerous type of spontaneous venous thrombosis in the legs was seen in six men, during a two-year period. All of these men were over 6 ft. (182.88 cm.) tall, and four of them were 6 ft. 2 in. (187.96 cm.) or more. In none of these patients did the venous thromboses follow surgical operations, but in each case they appeared after severe physical strain or for no apparent reason. In all of the many other patients seen with thrombophlebitis over the same two-year period, the thromboses occurred either postoperatively or post-partum, or as a result of malignancy, prolonged illness, or involved superficial varicose veins. In three of the tall patients pulmonary infarction was the first symptom, and five required either iliac or femoral vein ligation. All six of these patients had, initially or eventually, bilateral involvement. Two of the patients had pulmonary emboli while receiving anticoagulants, and a third
Coronary Artery Vasculitis as a Presentation of Cardiac Sarcoidosis
Authors: Emily V. Ward, Jose Nazari, Robert R. Edelman
Journal: Circulation (2012)

A 40-year-old white man was admitted for excision of a subcutaneous lesion on his torso.He reported a 12-month history of shortness of breath and exertional chest pain, both of which were relieved by rest.The patient was otherwise asymptomatic, and physical examination was noncontributory.He was not taking any medications.Electrocardiographic monitoring during the procedure revealed third-degree heart block with junctional escape and right bundle-branch block at 38 bpm (Figure 1).The patient was hemodynamically stable.An electrophysiology consultation was requested, and the patient was found to have an elevated serum angiotensin-converting enzyme level.Histological examination of the biopsy specimen showed noncaseating granulomata, which confirmed the diagnosis of sarcoidosis.
Streamlined stroke services in London save lives and money, study finds
Authors: N. Hawkes
Journal: BMJ (2013)

The reorganisation of stroke care in London has saved more than 400 lives since it was implemented in 2010, and costs less per patient than the old arrangements, a new study has found.1

Charles Davie, consultant neurologist at the Royal Free Hospital in London, and a member of the research team behind the study, said, “A system directing patients to high quality stroke units in the first 72 hours following stroke saves lives and money.” 

London introduced a “hub and spoke” stroke service in 2010, with care in the first 72 hours after stroke concentrated in …
NHS should be removed from government control
Authors: L. Beecham
Journal: BMJ (2002)

The BMA wants an independent executive answerable to parliament to take over responsibility for managing the NHS.

Dr Patrick Lintott from Oxford told the association's annual representative meeting last week that while the government controlled the service it would never flourish. He welcomed the additional money promised by the government but said that many problems remained and the constant changes caused disillusionment.

“Separate health targets, waiting list targets, immunisation targets from political targets; …
Preventability of neonatal cold injury and its contribution to neonatal mortality.
Authors: J R Goldsmith, Y Arbeli, D Stone
Journal: Environmental Health Perspectives (1991)

When the body temperature of a small neonate falls below 35 degrees C, lassitude can be noted; severe derangements of cardiovascular, renal, hepatic, immunological, and hematological systems may also occur depending in part on the duration and severity of hypothermia. Diagnosis requires a low-reading thermometer, lacking which the diagnosis can be suspected, but most often is missed. Fatal cases of diagnosed cold injury commonly have terminal pneumonia or sepsis. Prevention involves identification and home visits to high-risk infants; intensive care of those with the diagnosis at Soroka Hospital Medical Center has reduced the case-fatality rate from 30% in 1971 to 3% in 1988-1989. During the same period in our region, the proportion of neonatal deaths occurring in winter months of December, January, and February has dropped from 55 to 27%. The expected proportion is 25%. We hypothesize that excess neonatal mortality during winter months, especially due to pneumonia and sepsis or sudden infant death syndrome (SIDS) is an indicator of missed cold injury syndrome. A preliminary evaluation was made form U.S. data by state, provided by the National Center for Health Statistics, which records no fatalities from cold injury during 1986. Contrasted with this are 26 cold injury deaths in Israel for 1977-1980. In the U.S., though, excess winter neonatal deaths in 1986 from SIDS, pneumonia, and sepsis are reported.(ABSTRACT TRUNCATED AT 250 WORDS)
Aetiology and Management of Bronchiolitis and Pneumonia in Childhood
Authors: F. M. Elderkin, P. S. Gardner, D. C. Turk, A. C. White
Journal: BMJ (1965)

Cancer in East Africa-Hutt and Burkitt CAJO has gleaned information which indicates that several non- neoplastic conditions exhibit even more striking patterns of distribution which warrant further study.The statistical purist may well comment that figures for cancer incidence based on such evidence are useless.We do not believe this to be true, and we feel that in an area such as this every factual piece of knowledge is of value. SummaryCarcinoma of the penis, Kaposi's sarcoma, squamous-cell carcinoma of the skin, oesophageal cancer, and gastric carci- noma have a variable incidence in different parts of Uganda and probably in other areas of East Africa.General statements about cancer in Africans should therefore be accepted with reserve.More accurate figures are needed before studies on aetiology can be started.These figures may be attained by a combined approach on the part of the clinician and patho- logist.Personal contact is an essential feature of such a programme.Our thanks are due first to the Ministries of Health of Uganda, Kenya, Tanzania, and Rwanda for their permission to make these safaris and to visit Government hospitals.We would also like to thank all the doctors in both Government and Mission hospitals throughout East Africa for giving up valuable time to discuss their work.Finally, we would like to thank all our colleagues in the New Mulago Hospital and the Makerere University College Medical School for their help, advice, and co-operation.We would also like to acknowledge our debt to Professor J.
Psychological Care During Pregnancy and the Postpartum Period
Authors: Mona M. Shangold
Journal: JAMA (1980)

This clinically oriented work addresses a subject that deserves much more attention than it has ever received. The author, a psychiatrist, has succeeded in offering material of interest to an audience of wide and divergent backgrounds. As a necessary result, sections of the work will be of little interest to individual readers. In attracting an audience that includes obstetricians, midwives, nurses, physician's assistants, family practice physicians, and students in all of these professions, the text will oscillate in its literary and practical appeal to each reader. The greatest achievement of this book is its superb discussion of interviewing techniques, which is probably useful to readers at all levels. The acquisition of effective communications skills for interaction with patients is easy and natural for some but difficult for others. The author has succeeded in providing helpful concepts for neophytes that will serve equally well as refreshers to those who have practiced
Management of Helicobacter pylori-Positive Patients with Dyspepsia
Authors: David N. Schwartz
Journal: Annals of Internal Medicine (1997)

Letters1 August 1997Management of Helicobacter pylori-Positive Patients with DyspepsiaDavid N. Schwartz, MDDavid N. Schwartz, MDCook County Hospital; Chicago, IL 60612Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-3-199708010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Ofman and colleagues' decision analysis [1] supports the superior cost-effectiveness of empirical anti-Helicobacter pylori treatment compared with endoscopy-based therapy for patients with uncomplicated dyspepsia, but these authors do not consider whether widespread acceptance of this strategy could alter the epidemiology of this disorder in ways that would inflate its economic and ecologic costs. Although difficult to measure precisely, the prevalence of indigestion is undoubtedly large: In one study [2], 38% of respondents reported having had dyspeptic symptoms within the previous 6 months, another 26% reported having had such symptoms in the more distant past, and an 11.5% ...References1. Ofman JJ, Etchason J, Fullerton S, Kahn KL, Soll AH. Management strategies for Helicobacter pylori-seropositive patients with dyspepsia: clinical and economic consequences. Ann Intern Med. 1997; 126:280-91. Google Scholar2. Jones R, Lydeard S. Dyspepsia in the community: a follow-up study. Br J Clin Pract. 1992; 46:95-7. Google Scholar3. Taylor DN, Parsonnet J. Epidemiology and natural history of Helicobacter pylori infection. In: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL, eds. Infections of the Gastrointestinal Tract. New York: Raven Pr; 1995:551-63. Google Scholar4. Tompkins LS, Falkow S. The new path to preventing ulcers. Science. 1995; 267:1621-2. Google Scholar Author, Article, and Disclosure InformationAffiliations: Cook County Hospital; Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1997Volume 127, Issue 3Page: 244KeywordsAntimicrobial resistanceAntimicrobialsDecision analysisEpidemiologyPathogensPrevention, policy, and public healthVaccines Issue Published: 1 August 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Points: Time for action on hepatitis B
Authors: P. Board
Journal: BMJ (1987)

recognised or treated properly.As there is no widely accepted treatment for myalgic encephalomyelitis as an "organic" disorder it is important to recognise and treat any reversible illness, particularly if patients face "a long period of physical incapacity ... from ten to twenty years."'Physical and psychological assessment of patients with suspected myalgic encephalomyelitis may help to prevent more suicides in patients with this disorder.' 1 Ramsay AM.Post-viral fatigue syndrome: the saga of Royal Free disease.
A Case of Ileocolic Intussusception from Renal Cell Carcinoma
Authors: R. Deguchi, None Takagi, None Igarashi, None Shirai, None Shiba, None Watanabe, None Kurumada, None Miwa, None Sadahiro, None Yasuda
Journal: Endoscopy (2000)

We report a case of ileal metastasis of renal cell carcinoma (RCC) in a 58-year-old male. The patient had a history of radical nephrectomy for a right RCC, and 2 years later underwent bilateral partial pneumonectomy for metastatic disease of the lung. A period of 1 year after the partial pneumonectomy, he developed bloody stools. Colonoscopy revealed an ileocolic intussusception caused by a polypoid tumor in the ileum, and the tumor was observed to be protruding into the ascending colon. The histological features of the tumor biopsy specimen confirmed the diagnosis of metastatic RCC. Metastasis of RCC in the small bowel is a rare disease clinically. To our knowledge, this is the first reported case with ileal metastasis of RCC, which has been definitively diagnosed by colonoscopy.
Tolbutamide: More Questions Than Answers
Authors: William R. Barclay
Journal: JAMA (1971)

The University Group for Diabetes Program (UGDP) study has raised a storm of controversy, provoked action by the FDA, and focused attention on a number of questions not asked in the original study protocol. The intent of the study was to examine the effect of three drug treatment regimens and a diet regimen on the course of mild, adult-onset, nonketogenic diabetes. The study was honestly conceived, carefully planned, and conducted by "experts" in 12 university centers. If the institutions and the people involved do not represent the best, they certainly represent a high degree of excellence in the field of diabetes. The investigation, which extended over a period of eight years, was supported by the National Institutes of Health, and the purposes, design, and conduct were subjected to careful scrutiny and criticism by an NIH study section. Progress reports were submitted and performance of the study group, as judged by
Color Atlas of Pediatric Diseases With Differential Diagnosis
Authors: Murray Feingold
Journal: JAMA (1990)

This is the second edition of this color atlas. Most of the 14 chapters discuss specific organ systems, although there are chapters on the newborn, congenital anomalies, metabolic diseases, and nutritional disorders. It is especially important that before purchasing this book, you are aware of what it does and does not provide. There are 702 excellent color photographs covering a large number of pediatric diseases. Its main drawback, however, is superficiality. The authors dostate, "A comprehensive discussion of every conceivable symptom was not our intent," and "Medical students can use the book as a supplement to a basic text." These admonitions are very valid. A good example is the six lines and one photograph concerning the Goldenhar syndrome. The photograph demonstrates a right preauricular appendage, macrostomia, and a fair view of mandibular hypoplasia. This could represent hemifacial microsomia (most researchers believe they may be the same condition), and although the