tbuckley/cabot-search huggingface dataset:
Appropriateness of Spinal Manipulation
Authors: Louis Sportelli
Journal: Annals of Internal Medicine (1999)

Letters5 January 1999Appropriateness of Spinal ManipulationLouis Sportelli, DCLouis Sportelli, DCSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-1-199901050-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Shekelle and colleagues (1) suggested that “spinal manipulation” was inappropriately used on 29% of patients. This statement alone could cause an avalanche of negative litigation, simply because the “general public” cannot discern the nuances of what is meant by the term “inappropriate.” Shekelle says that chiropractors can be treated just like medical doctors, and the chiropractic community is ready and willing to meet that challenge. Are we to suggest that every time aspirin is used for a condition that it has not been specifically researched for, it would be deemed “inappropriate”? I seriously doubt that.It should ...References1. Shekelle PG, Coulter I, Hurwitz EL, Genovese MA, Adams AH, Mior SA, et al . Congruence between decisions to initiate chiropractic spinal manipulation for low back pain and appropriateness criteria in North America. Ann Intern Med. 1998;129:9-17. LinkGoogle Scholar2. Bigos SJ, Bowyer O, Braen G, Brown K, Deyo R, Haldeman S, et al. Acute Low Back Pain Problems in Adults: Clinical Practice Guideline no. 14. Rockville, MD: US Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research; 1994. AHCPR publication no. 95-0643. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCongruence between Decisions To Initiate Chiropractic Spinal Manipulation for Low Back Pain and Appropriateness Criteria in North America Paul G. Shekelle , Ian Coulter , Eric L. Hurwitz , Barbara Genovese , Alan H. Adams , Silvano A. Mior , and Robert H. Brook Appropriateness of Spinal Manipulation Paul G. Shekelle , Ian A. Coulter , and Robert H. Brook Appropriateness of Spinal Manipulation Peter G. Hill Appropriateness of Spinal Manipulation Myron M. LaBan and Ronald S. Taylor Metrics 5 January 1999Volume 130, Issue 1Page: 75-76KeywordsAspirinChiropracticHealth careHealth information technologyLower back painSpine Issue Published: 5 January 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
WNT signaling underlies the pathogenesis of neuropathic pain in rodents
Authors: Yan-Kai Zhang, Zhi-Jiang Huang, Su Liu, Yue-Peng Liu, Angela A. Song, Xue-Jun Song
Journal: Journal of Clinical Investigation (2013)

Treating neuropathic pain is a major clinical challenge, and the underlying mechanisms of neuropathic pain remain elusive. We hypothesized that neuropathic pain–inducing nerve injury may elicit neuronal alterations that recapitulate events that occur during development. Here, we report that WNT signaling, which is important in developmental processes of the nervous system, plays a critical role in neuropathic pain after sciatic nerve injury and bone cancer in rodents. Nerve injury and bone cancer caused a rapid-onset and long-lasting expression of WNTs, as well as activation of WNT/frizzled/β-catenin signaling in the primary sensory neurons, the spinal dorsal horn neurons, and astrocytes. Spinal blockade of WNT signaling pathways inhibited the production and persistence of neuropathic pain and the accompanying neurochemical alterations without affecting normal pain sensitivity and locomotor activity. WNT signaling activation stimulated production of the proinflammatory cytokines IL-18 and TNF-α and regulated the NR2B glutamate receptor and Ca2+-dependent signals through the β-catenin pathway in the spinal cord. These findings indicate a critical mechanism underlying the pathogenesis of neuropathic pain and suggest that targeting the WNT signaling pathway may be an effective approach for treating neuropathic pain, including bone cancer pain.
A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.
Authors: J E Parrillo, C Burch, J H Shelhamer, M M Parker, C Natanson, W Schuette
Journal: Journal of Clinical Investigation (1985)

We have previously described a subpopulation of patients with septic shock who had a reversible depression of radionuclide-determined left ventricular ejection fraction (EF). To investigate the mechanism of this myocardial depression, an in vitro model of mammalian myocardial cell performance was established employing primary spontaneously beating rat myocardial cells. The contraction of a single cardiac cell was quantitated by recording the changes in area occupied by the cell during contraction and relaxation. In 20 septic shock patients during the acute phase, the mean left ventricular EF was decreased (mean = 0.33, normal mean = 0.50), and serum obtained during this acute phase induced a mean (+/- standard error of the mean) 33 +/- 4% decrease in extent and 25 +/- 4% decrease in velocity of myocardial cell shortening during contraction (P less than 0.001). In contrast, serum obtained from 11 of these same patients before shock (n = 2) or after recovery (n = 9) of the left ventricular EF (mean = 0.50) showed a return toward normal in extent and velocity of shortening (P less than 0.001). Sera from 17 critically ill nonseptic patients, from 10 patients with structural heart disease as a cause for a depressed EF, and from 12 healthy laboratory personnel, induced no significant changes in in vitro myocardial cell performance. In 20 patients during the acute phase of septic shock, the decreased EF in vivo demonstrated a significant correlation (r = +0.52, P less than 0.01) with a decrease in the extent of myocardial cell shortening in vitro. The quantitative and temporal correlation between the decreased left ventricular EF and this serum myocardial depressant substance argues for a pathophysiologic role for this depressant substance in producing the reversible cardiomyopathy seen during septic shock in humans.
Linkage analysis and long QT syndrome. Using genetics to study cardiovascular disease.
Authors: M Keating
Journal: Circulation (1992)

BACKGROUND Recombinant DNA technologies have facilitated the development of a set of polymorphic DNA markers covering the human genome. General linkage analysis in families predisposed to inherited disease is now feasible. Linkage analysis can help identify a disease gene even when relatively little is known about the disorder. METHODS AND RESULTS Using this approach, we have identified linkage between a gene that causes the long QT syndrome and DNA markers on chromosome 11. CONCLUSIONS The identification of the chromosomal location of the long QT locus is the first step in defining the specific mutations that cause this disease.
Diabetes As a Way of Life
Authors: Henry T. Ricketts
Journal: JAMA (1970)

This revision of Dr. Danowski's earlier book is the latest of many similar guides for the diabetic patient. It is written by an author of long experience. Its coverage of the subject is complete—perhaps more complete than necessary, as when the patient is introduced to the biochemistry of glucose metabolism with such terms as glucose-phosphate and CO 2 . The prose is readable without conveying condescension. Where the facts of diabetes might justify gloom, the tone is kept cheerful, as perhaps it should be. This effort at optimism, however, sometimes results in unverifiable statements, eg, the claims that 99% of diabetics retain normal vision for life and that an equal percentage have normal kidney function until they die.  The book is sparingly illustrated and not always usefully: the reviewer finds unfelicitous certain of the graphs portraying the time curves of long-acting insulin because they represent the effect of only a single
Abstract 3041: GPR56 promotes the adhesion of glioma stem-like cells to the perivascular niche and regulates cell fate
Authors: Marta Moreno, Stefanie Giera, Xianhua Piao, Nuria de la Iglesia
Journal: Cancer Research (2014)

Abstract INTRODUCTION Gliobastomas (GBM) are the most aggressive and frequent human malignancies in the central nervous system. A small population of cells within the bulk of these tumors displays properties of normal neural stem cells (NSC). Accordingly, these cells are referred to as glioma stem-like initiating cells (GIC). Thus, deregulation of mechanisms that control NSC biology might contribute to the pathogenesis of GBM. NSC and GIC are localized to the perivascular space where they reside in close apposition to blood vessels (BV), which promote self-renewal and keep these cells in an undifferentiated state. GPR56 is an adhesion G-protein coupled receptor expressed in neural progenitors in the embryonic and adult brain and plays an indispensable role in cortical development. Knockout mice studies show that GPR56 mediates the attachment of radial glial endfeet to pial basement membrane (BM). Some of the components of the pial BM are also present in the extracellular matrix surrounding BV, such as laminin and collagen. Therefore, we hypothesized that GPR56 might mediate NSC/GIC localization to the perivascular niche thus contributing to their stem-related properties. EXPERIMENTAL PROCEDURES Here, we have compared the expression of GPR56 in neural progenitors versus more differentiated progeny. In addition, we have assessed the role of GPR56 in the neural stem-like properties of GIC, including their differentiation into more mesenchymal cell types such as endothelial cells or pericytes, by gain- and loss-of-function studies. RESULTS We have found that GPR56 is highly expressed in NSC and its expression is downregulated during differentiation. We have also observed that GPR56 is expressed in cells that reside in the perivascular niche. GPR56-knockdown GIC display impaired adhesion to endothelial cells (EC), whereas GPR56 overexpression increases their adhesion to EC. Furthermore, loss of GPR56 increases the ability of GIC to express endothelial/pericyte markers when co-cultured with EC and increases the CD44+ population, suggesting that GPR56 inhibits the acquisition of a mesenchymal-like phenotype. CONCLUSIONS Taken together, our findings indicate that GPR56 mediates the adhesion of GIC to EC. Moreover, GPR56 inhibits the acquisition of mesenchymal features. Therefore, we suggest that GPR56 might mediate the attachment of GIC to the perivascular niche while preserving their neural stem-like properties by preventing the acquisition of a mesenchymal-like phenotype. Citation Format: Marta Moreno, Stefanie Giera, Xianhua Piao, Nuria de la Iglesia. GPR56 promotes the adhesion of glioma stem-like cells to the perivascular niche and regulates cell fate. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3041. doi:10.1158/1538-7445.AM2014-3041
Treatment of Group A Streptococcal Pharyngotonsillitis
Authors: John Goldenring
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The recent article by Schwartz et al on "Penicillin V for Group A Streptococcal Pharyngotonsillitis" (1981;246:1790) is another good study by that group on the treatment of common problems faced daily by every clinician. I am perfectly ready to accept their suggestion of ten-day oral penicillin treatment for my patients here in California, where the incidence of rheumatic fever is virtually nil. However, if I practiced in an area where the incidence of rheumatic fever was higher, I would not be satisfied with giving an oral medication and having a 65% to 80% compliance rate. This is especially true since Schwartz et al are reporting on a population of middle-class suburbanites who would be expected to have the highest possible compliance. Most other populations should do far worse and have poorer follow-up.<sup>1</sup> Rather, I would opt to inject all my patients who have a positive<i>Streptococcus</i>
Regulation of ERK/JNK/p70S6K in two rat models of liver injury and fibrosis
Authors: Gianluca Svegliati-Baroni, Francesco Ridolfi, Zaira Caradonna, Domenico Alvaro, Marco Marzioni, Stefania Saccomanno, Cinzia Candelaresi, Luciano Trozzi, Giampiero Macarri, Antonio Benedetti, Franco Folli
Journal: Journal of Hepatology (2003)
Specialist registrars' plans for working part time as consultants in medical specialties: questionnaire study
Authors: H. M Mather
Journal: BMJ (2001)

Almost 40% of all specialist registrars who hold national training numbers in medical specialties are women.1 Little is known about their career intentions, and specifically on how they plan to cope with the competing pressures of family and career when they become consultants. Questions on this issue were therefore included in a recent national survey of specialist registrars.

The Royal College of Physicians sent a questionnaire in December 1999 to all 2495 trainees in England, Wales, and Northern Ireland holding national training numbers in medical specialties. Replies were received from 1362 (55%), of whom 1311 answered the question, would you like a part time (eight sessions or less) post when you become a consultant? They had five options: “yes—definitely,” “yes—probably,” “yes—possibly,” “no—probably not,” and “no—definitely not.” The number and percentage of women (n=541) giving each response were …
Abstract P2-12-07: The correlation between Myriad Genetic Laboratories, Inc. mutation prevalence table and clinicopathological characteristics of breast cancer patients in Okinawa
Authors: M Arakaki, Y Kamada, K Uehara, K Tamaki, N Tamaki
Journal: Cancer Research (2013)

Abstract Introduction The two major susceptibility genes for breast cancer and ovarian cancer, BRCA1 andBRCA2 were discovered in 1994 and 1995, respectively. Various risk prediction algorithms and models have been developed to identify putative BRCA1/2 mutation carriers. Myriad Genetic Laboratories, Inc. released Mutation Prevalence Tables (http://www.myriad.com/lib/brac/brca-prevalence-tables.pdf#search = ‘Myriad+Genetic+Laboratories%2C+Inc.+Mutation+Prevalence+Table’) through its clinical testingservice. To the best of our knowledge, this is the first study to examine the correlation between this risk prediction model and clinicopathological characteristics of breast cancer patients. Methods The cases were 148 female breast cancer patients without any previous breast cancer history who initially visited Nahanishi Clinic Okinawa in Okinawa, Japan, between May 2012 and March 2013. The median ages were 55 years old (26-84). We examined the correlation between Myriad Genetic Laboratories, Inc. released Mutation Prevalence Tables and clinicopathological characteristics including age, ER, PgR, HER2, triple negative status, histological grade and Ki67. The presence of ER and PgR was determined by nuclear staining with positive cases defined as more than 1% staining according to ASCO CAP. With regard to HER2 evaluation, membranous staining was graded as 0-1+, 2+, and 3+. Samples scored as 2+ were subjected to FISH. Positivity was defined as a HER2:CEP17 signal ratio&amp;gt;2.2. Ki-67 labeling index was obtained by selecting the hot spots after evaluation at low power magnification and counting 1000 tumor cells in the hotspots. Results There was statistically negative correlation between the risk prediction rates and age (r = -0.480, r2 = 0.230, p&amp;lt;0.001). The risk prediction rates of ER negative and positive were 2.93±4.12% and 4.06±9.53% with statistically significant differences (p = 0.049).On the other hand, tendency was detected in PgR status (p = 0.058), and the risk prediction rates were 3.21±1.92% of PgR negative and 4.24±3.34% of PgR positive, respectively. The risk prediction rates of triple negative cases and non triple negative cased were 2.58±0.94% and 4.06±3.11% with statistically significant differences (p&amp;lt;0.001). There were not statistically significant differences in HER2 status, histological grade and Ki67, respectively. Conclusion Previous studies demonstrated that BRCA1/2 mutation was associated with triple negative and high grade malignant breast cancer. However, the results of this study suggested that Myriad Genetic Laboratories, Inc. released Mutation Prevalence Tables was not associated with triple negative and/or high risk breast cancer patients in Okinawa. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P2-12-07.
Myoclonus associated with treatment with high doses of morphine: the role of supplemental drugs.
Authors: J. M. Potter, D. B. Reid, R. J. Shaw, P. Hackett, P. E. Hickman
Journal: BMJ (1989)

OBJECTIVE--To estimate the prevalence of important side effects in patients with malignant disease who were receiving high doses of morphine as part of their palliative treatment. DESIGN--Data on patients were collected over 12 months. SETTING--Two palliative care units in Western Australia. PATIENTS--19 Patients with malignant disease who were receiving morphine either subcutaneously or orally as the main analgesic. 10 Patients receiving a total daily dose of morphine of at least 500 mg orally or 250 mg parenterally were enrolled in the study. The other 9 patients were enrolled after an important problem thought to be related to the morphine had been identified. All of the patients were taking drugs to supplement the treatment. INTERVENTIONS--The dose of morphine or route of administration, or both, was changed in three patients. MAIN OUTCOME MEASURE--Determination of the prevalence of side effects in the patients. Assessment of the relation of any side effects with the supplemental drugs taken by the patients. MAIN RESULTS--Plasma morphine and electrolyte concentrations were measured and a full history taken for each patient. Thirteen of the 19 patients had an important side effect; 12 of them had myoclonus and one had hyperalgesia of the skin. Plasma morphine concentrations were similar in patients with and without myoclonus, ranging from 158 to 3465 nmol/l and 39 to 2821 nmol/l respectively. Eight of the patients with side effects were taking an antipsychotic drug concurrently compared with none of those without side effects. A greater proportion of patients with side effects were taking the antinauseant drug thiethylperazine (6/13 v 2/6) and at least one non-steroidal anti-inflammatory drug (10/13 v 2/6), whereas a smaller proportion were taking a glucocorticosteroid (3/13 v 4/6). The estimated prevalence of important side effects in the total population of patients receiving palliative treatment in the two units was 2.7-3.6%. CONCLUSIONS--Myoclonus as a side effect of treatment with morphine is more likely to occur in patients taking antidepressant or antipsychotic drugs as antiemetics or as adjuvant agents or non-steroidal anti-inflammatory drugs for additional analgesia. If a patient develops myoclonus the best approach may be to change the supplemental treatment.
Prognostic value of nonlinear measures of heart rate dynamics in chronic hemodialysis patients with coronary artery disease
Authors: Hidekatsu Fukuta, Jun-ichiro Hayano, Shinji Ishihara, Seiichiro Sakata, Hiroshi Takahashi, Masaki Yokoya, Takanobu Toriyama, Hirohisa Kawahara, Genjiro Kimura
Journal: Journal of the American College of Cardiology (2002)
Kidney Function During and After Withdrawal of Long-Term Irbesartan Treatment in Patients With Type 2 Diabetes and Microalbuminuria
Authors: Steen Andersen, Jens Bröchner-Mortensen, Hans-Henrik Parving
Journal: Diabetes Care (2004)

We thank Kaiser, Florack, and Sawicki (1) for their interest in our article (2). The glomerular filtration rate (GFR) values in Fig. 2 represent the mean values of measurements carried out at the specified visits. However, the rates of decline in GFR cannot be correctly estimated from Fig. 2, but are instead calculated from paired observations of changes in GFR and specified in the results section. GFR values at baseline were available …
Molecular cloning and characterization of full‐length cDNAs encoding a novel high‐molecular‐weight <i>Dermatophagoides pteronyssinus</i> mite allergen, Der p 11
Authors: L. C. Tsai, H. J. Peng, C. S. Lee, P. L. Chao, R. B. Tang, J. J. Tsai, H. D. Shen, M. W. Hung, S. H. Han
Journal: Allergy (2005)

Background: Dermatophagoides pteronyssinus (Dp) and D. farinae (Df) mites are the most important source of indoor aeroallergens. Most Dp mite allergens identified to date have relatively low molecular weights (MWs). Identification of high‐MW mite allergens is a crucial step in characterizing the complete spectrum of mite allergens and to provide appropriate tools for diagnostic and therapeutic application. Methods: The full‐length Der p 11 cDNA clone was isolated using cDNA library immunoscreening, the 5′–3′ rapid amplification of cDNA ends (RACE) system and polymerase chain reactions (PCR). The whole cDNA insert and its PCR‐derived DNA fragments (p1 to p4) were generated and expressed in the Escherichia coli expression system. The allergenicity of the recombinant protein and its peptide fragments was examined by IgE immunodot assays. The IgE‐binding reactivity of rDer p 11 was analyzed in the serum of 50 asthmatic children with positive reactivity to Dp mite extract. Its recombinant peptide fragments were also examined by immunodot assays in 30 mite‐allergic children. Results: Der p 11 cDNA consists of a 2625‐bp open reading frame encoding a 103‐kDa protein with 875 amino acids. It exhibits significant homology with the paramyosin of other invertebrates. The protein sequence alignment of this newly identified Dp mite allergen (denominated as Der p 11) revealed over 89% identity with Der f 11 and Blo t 1. Among 50 Dp‐sensitive asthmatic children, rDer p 11 showed positive IgE‐binding reactivity to 39 patients (78%). Using immunodot assays, multiple human IgE‐binding activities were demonstrated in all four fragments of Der p 11. Using immunoblot assays, the dominant IgG‐binding epitope for monoclonal antibody (mAb642) was located in fragment p3 only. In immunoblot assays, cross‐inhibition between rDer p 11 and rDer f 11 was up to 73–80% at concentrations of 100 μ g/ml. Conclusions: This study confirms that the newly identified recombinant Der p 11 is a novel and important high‐MW Dp mite allergen for asthmatic children. Our data also indicates that human IgE‐binding major epitopes are scattered over the entire molecule of Der p 11.
(8) Tufted angioma
Authors: E.D.A. Potts
Journal: British Journal of Dermatology (1987)

Journal Article (8) Tufted angioma Get access E.D.A. Potts E.D.A. Potts Halifax General Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 54–56, https://doi.org/10.1111/j.1365-2133.1987.tb12049.x Published: 01 June 1987