tbuckley/cabot-search huggingface dataset:
Limitations of the Electrocardiographic Response to Exercise in Predicting Coronary-Artery Disease
Authors: Jeffrey S. Borer, John F. Brensike, David R. Redwood, Samuel B. Itscoitz, Eugene R. Passamani, Neil J. Stone, John M. Richardson, Robert I. Levy, Stephen E. Epstein
Journal: New England Journal of Medicine (1975)

The electrocardiographic response to exercise was compared with the results of coronary angiography in 89 patients with Type II hyperlipoproteinemia who had previous myocardial infarction or typical angina or both (43 patients) (Group A), "atypical angina" (16 patients) (Group B) or positive electrocardiographic response to exercise without other evidence of cardiac disease (30 patients) (Group C). Thirty-nine of 43 in Group A had ≥50 per cent stenosis, and 26 (67 per cent) of these 39 had negative exercise tests. In Group B, five of 16 had ≥50 per cent Stenosis, and three had positive exercise tests (one patient had a false-positive test). In Group C, eleven of 30 (37 per cent) had ≥50 per cent stenosis; however, nine (30 per cent) had minor stenoses (≤50 per cent), and 10 (33 per cent) normal coronary arteries. The diagnostic usefulness of exercise electrocardiography is limited. False-negative responses are frequent in patients with clinically suspected coronary disease, and false-positive responses frequent in asymptomatic patients. (N Engl J Med 293:367–371, 1975)
Generalist Physicians and Addiction Care
Authors: Michael D. Stein, Peter D. Friedmann
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increased deposition of fibulin-2 in solar elastosis and its colocalization with elastic fibres
Authors: N. Hunzelmann, R. Nischt, P. Brenneisen, A. Eickert, T. Krieg
Journal: British Journal of Dermatology (2001)

Background Fibulin-2 is a 195-kDa protein belonging to a novel family of extracellular matrix proteins that might be involved in microfibril and elastic fibre organization. Objectives To determine the localization of fibulin-2 in relation to elastic fibres in normal skin and in solar elastosis characterized by increased elastotic material in the papillary dermis. Methods The expression and synthesis of fibulin-2 was investigated by means of in situ hybridization, immunohistochemistry and Western blot analysis in normal and photoaged skin. Results Immunohistochemistry and elastic tissue staining revealed that fibulin-2 deposition mainly colocalized with microfibrils and elastin fibres, with a marked staining of elastotic material in solar elastosis. Western blot analysis demonstrated that in photoaged skin fibulin-2 showed the same electrophoretic mobility as in sun-protected skin. However, in actinic elastosis the amount of fibulin-2 was significantly higher. In addition, smaller degradation products were detectable, presumably reflecting increased proteinase activity in photodamaged skin. Conclusions This study shows that deposition of fibulin-2 and elastin is highly co-ordinated, indicating that this protein plays an important role in elastic fibre and microfibril formation in normal and actinically damaged skin.
AN INQUIRY INTO THE CAUSE OF ANGINA PECTORIS
Authors: J. Mackenzie
Journal: BMJ (1905)

feeling of weakness, and fell to the floor in a faintiDg condition.When seen by Dr. Fotheringham a sbort time after he was extremely c5anosed, the heart's impulse diffused and fluttering, and the pulse impereeptrible.After a few hours he was removed to his home.Evi- deuce of dilatation of both ventricles was present, most markedly of the left.Every effort to overcome the condition was of no avail, death- occurring in a week from the onset of the attack.Autopsy reveaied marked hypertrophy of both sides of 1he heart with extreme dilatation of both ventricles.The cardiac muscle was pale, soft and flabby, and showed " tabby-cat" streaking beneath the endocardium.There was no vaivular trouble.The fatal issue of this ca%e was nearly a year and a half after his attack of typhoid fever.The splendid muscular development of the patient, with the imoatlence to restraint so often, seen in those who have always enjoyed vigorous health, unfortunately became causes for overtaxing the myocardium, weakened out of propor- tion to the general strength.
The Frequency of Lupus Anticoagulant in Systemic Lupus Erythematosus
Authors: MICHELLE PETRI
Journal: Annals of Internal Medicine (1987)

Recent reviews have suggested a higher frequency of the lupus anticoagulant or related antiphospholipid antibodies in patients with systemic lupus erythematosus (21% to 65%) than was found in earlier studies (6% to 18%). In our study of 60 consecutive patients, we found the frequency of the lupus anticoagulant by Russell viper venom time was 6.7% (95% confidence interval, 16.2 to 1.8) and by anticardiolipin antibody assay was 25% (95% Cl, 37.0 to 15.7), compared with 0% (p = not significant) and 2.5% (p = 0.002), respectively, in the normal control population. The Russell viper venom time (p = 0.0001 by t-test) and anticardiolipin antibody levels (p = 0.01) were significantly associated with presumed thrombotic events (stroke, deep venous thrombosis, and digital gangrene). No association with miscarriage or pulmonary hypertension was detected. The Russell viper venom time was more specific than the anticardiolipin antibody level in the prediction of past presumed thrombotic events, miscarriage, or pulmonary hypertension (100% compared with 84%, p = 0.01).
TCT-740 Transfemoral Aortic Valve Implantation of Edwards Sapien XT without Pre-dilatation is feasible
Authors: Christoph Liebetrau, Won-Keun Kim, Johannes Blumenstein, Joerg Kempfert, Holger Nef, Arnaud Van Linden, Thomas Walther, Helge Moellmann
Journal: Journal of the American College of Cardiology (2014)
Effect of Progressive Pressure Reduction with Nitroprusside on Acute Myocardial Infarction in Humans
Authors: MONTY M. BODENHEIMER
Journal: Annals of Internal Medicine (1981)

The effect of nitroprusside-induced progressive systemic pressure reduction on segmental function in patients with acute myocardial infarction is unclear. In 15 patients control radionuclide angiograms were obtained at control within 24 hours of the onset of chest pain and during the administration of intravenous nitroprusside. The initial study showed a significant reduction in hemiaxial shortening in the zone of myocardial infarction. With nitroprusside, systolic pressure was decreased from a mean of 133 mm Hg to an intermediate pressure of 116 mm Hg (p < 0.001). At this pressure central chord hemiaxial shortening increased in eight of 15 zones with an average increase from 10.1% to 27.8% (p < 0.006). After further reduction in pressure to 87.1 mm Hg, an additional five of the seven remaining zones of acute infarction improved. However, of the eight zones that improved initially, four deteriorated at the lowest pressure. Similar changes were seen in the lateral chords. Thus, afterload reduction can improve hemiaxial shortening of the infarct zone. However, the degree of reduction in systemic pressure must be individualized to avoid adverse effects of an excessive decrease in perfusion pressure.
Intolerance to β‐blockade in a mouse model of δ‐sarcoglycan‐deficient muscular dystrophy cardiomyopathy
Authors: Ralf Bauer, Alison Blain, Elizabeth Greally, Kate Bushby, Hanns Lochmüller, Steve Laval, Volker Straub, Guy A. MacGowan
Journal: European Journal of Heart Failure (2010)
Inhibitory Neuron Transplantation into Adult Visual Cortex Creates a New Critical Period that Rescues Impaired Vision
Authors: Melissa F. Davis, Dario X. Figueroa Velez, Roblen P. Guevarra, Michael C. Yang, Mariyam Habeeb, Mathew C. Carathedathu, Sunil P. Gandhi
Journal: Neuron (2015)
Characterization of atrial flutter. Studies in man after open heart surgery using fixed atrial electrodes.
Authors: J L Wells, W A MacLean, T N James, A L Waldo
Journal: Circulation (1979)

Studies were performed using bipolar atrial wire electrodes to record atrial electrograms and to pace the atria in 27 patients who developed atrial flutter after open heart surgery.Two types of atrial flutter, classic or type I atrial flutter, and type II atrial flutter, were identified.Both types of atrial flutter were characterized by uniformity of the beat-to-beat atrial cycle length, morphology, polarity, and amplitude of the recorded bipolar atrial electrogram.Both types sometimes manifested a beat-to-beat electrical alternans, which in turn was sometimes associated with an alternans in beat-to-beat cycle length.The initial basis of separation of types I and II atrial flutter was that type I atrial flutter was always influenced by rapid atrial pac- ing from the high right atrium, and type II atrial flutter was not.Two additional observations suggested that types I and II atrial flutter were different, although related, rhythms: 1) In four patients, type II atrial flutter was present after termination of rapid atrial pacing used to treat type I atrial flutter; 2) in two patients, type II atrial flutter changed to type I atrial flutter in a one-step fashion.The range of rates of the two types of atrial flutter were also different type I atrial flutter was slower (range 240-338 beats/min) than type II (range 340-433 beats/min).We concluded that type II atrial flutter is a distinct rhythm which may be intermediate between classic, or type I, atrial flutter and atrial fibrillation.ATRIAL FLUTTER is a supraventricular arrhyth- mia which has long been recognized in man,' al- though its underlying mechanism has not been ex- plained.Based on the ECG, it has been characterized as a regular, rapid atrial rhythm, most often with an atrial rate close to 300 beats/min, with the upper and lower limits of its range uncertain and variously stated.2-8At our institution, at the time of open heart surgery, bipolar wire electrodes are routinely placed on the right atrial epicardium for possible diagnostic or therapeutic use in the immediate postoperative period.9-12Since many patients develop atrial flutter spontaneously during this latter period, this was an opportunity to use these electrodes to characterize and define this rhythm better while providing patient care.Methods Twenty-seven patients who developed atrial flutter in the immediate period after open heart surgery were studied.The atrial flutter was identified initially from a standard or monitored ECG, or from bipolar atrial electrograms recorded from a pair of atrial wire elec- trodes placed routinely 0.5-1.0cm apart on the epicar- dial surface of the superior portion of the right
INTERACTION BETWEEN AGE, NT-PROBNP AND MORTALITY RISK MAY EXPLAIN WHY A NT-PROBNP GUIDED THERAPY DOES NOT WORK IN THE ELDERLY HEART FAILURE PATIENT: A NORTHSTAR SUBSTUDY
Authors: Morten Schou, Per hildebrandt, Lars Videbaek, christian tuxen, Michael Egstrup, Jens Rosenberg, Mogens Andersen, Flemming Steffensen, Finn Gustafsson
Journal: Journal of the American College of Cardiology (2012)
Spironolactone use and renal toxicity: population based longitudinal analysis
Authors: L. Wei, A. D. Struthers, T. Fahey, A. D. Watson, T. M. MacDonald
Journal: BMJ (2010)

To determine the safety of spironolactone prescribing in the setting of the UK National Health Service.Population based longitudinal analysis using a record linkage database.Tayside, Scotland. Population All patients who received one or more dispensed prescriptions for spironolactone between 1994 and 2007.Rates of prescribing for spironolactone, hospital admissions for hyperkalaemia, and hyperkalaemia and renal function without admission, before and after the publication of results from the Randomised Aldactone Evaluation Study (RALES).Prescriptions for spironolactone and measurements of serum creatinine and serum potassium all increased in parallel in Tayside after the release of the RALES results in 1999 (from 2847, 5345, and 5246 in the first half of 1999 to 6582, 10,753, and 10,534 by the second half of 2001, and to 8619, 17,844, and 17,649 by 2007). These increases occurred in patients with and without heart failure. Few hospital admissions for hyperkalaemia occurred over this time: three in the first quarter of 1995, two in the last quarter of 2001, and three in 2007. Among patients who were taking angiotensin converting enzyme inhibitors and who had recently been admitted to hospital for heart failure, the rate of spironolactone use was 19.8 per 100 patients in early 1999 rising to 70.1 per 100 patients by late 2001 (P<0.01) and 61.3 by 2007. The rate of outpatient measured hyperkalaemia (serum K(+)>6 mmol/l) did not increase over time (9.9 per 100 patients in early 1999, 6.9 per 100 patients in late 2001, and 2.9 per 100 patients in 2007) despite the increased use of spironolactone.Despite a marked increased in the use of spironolactone in patients with and without heart failure, no increase was seen in hospital admissions for hyperkalaemia and outpatient hyperkalaemia actually fell. Careful monitoring of patients prescribed spironolactone seems to have been associated with no increase in risk of hyperkalaemia.
Asthma in the desert: spectrum of the sensitizing aeroallergens
Authors: C. I. Ezeamuzie, M. S. Thomson, S. Al‐Ali, A. Dowaisan, M. Khan, Z. Hijazi
Journal: Allergy (2000)

Bronchial asthma is common in Kuwait, a desert country, but the sensitizing allergens are uncertain. This study investigated the sensitizing allergens in Kuwaiti patients with extrinsic asthma.A total of 553 asthmatics (male:female ratio: 1.4; mean age: 31.7 years [range 3-76 years]) and 112 matched controls were studied. Sera from all patients/subjects were tested by the CAP-RAST method for specific IgE to 14 locally relevant inhalant allergens.Specific IgE to at least one allergen was detected in 87.2% of the patients compared with 24.1% of controls. Among the confirmed extrinsic asthmatics, the sensitization rates for the allergen groups were as follows: pollens (87.1%), house dust (76.1%), and molds (30.3%). The three most prevalent sensitizing pollens were from Chenopodium (70.7%), Bermuda grass (62.9%), and Prosopis (62.7%), all of which are horticultural plants imported for the purpose of "greening" the desert. For all allergens, except the molds, the prevalence rate was higher in males than females, but age had only a weak effect. Severe asthma occurred significantly more frequently among mold-sensitized patients.These results show that even in a desert environment, pollens and house-dust allergens may be important sensitizing allergens. They also illustrate how practices that "green" the desert can affect public health.
Effect of Posture on Exercise Performance
Authors: G. DE BACKER
Journal: Circulation (1974)

In the July issue of this journal' Drs.Spodick and Quarry-Pigott studied the influence of postural attitude on exercise performance measured by systolic time intervals.Recently we performed identical tests on five male volunteers between 27 and 32 years of age.However, in our schedule, the individuals were sub- jected to maximal tolerance tests in steps of 25 Watts during 4 min periods.Simultaneous registration of the carotid pulse tracing, ECG, and phonocardiograms were made every 2 min during the test and every minute during the recovery period.We found similar results (table 1) as Dr. Spodick; however, in our study there was a significant increase of LVETc and ETI in the supine position.Although this increase was not as important as the one which we obtained in the sitting position, the change in position accounts for about half of it.Since LVETc and ETI are merely influenced by changes of stroke volume,2 our results suggest that this volume does in- crease during supine exercise.
ACTIVE IMMUNIZATION AGAINST DIPHTHERIA IN PRIVATE PRACTICE
Authors: FRANK C. NEFF
Journal: JAMA (1923)

Protection against diphtheria needs not only the activity of an efficient health board in each community, but also the assistance of the private and dispensary physician; for it is from him that advice is sought. It is with the hope of creating more active general interest in this subject that this paper is presented. <h3>INCOMPLETE CONTROL OF DIPHTHERIA</h3> To diagnose this disease correctly is the duty of the practicing physician, for on him rests the responsibility of early administering antitoxin as a curative or prophylactic measure, and of urging the safeguarding of other individuals by isolation and quarantine. Passive immunization and isolation have their definite place, but that they have not been effectual in eradicating the disease is known to all, to a disappointing extent when one reads our recent statistics. Since the last session of the American Medical Association, from June 1, 1922 to April 1, 1923, there have
CHEMISTRY OF COLOSTRUM MILK; A REPORT OF SIX CASES
Authors: George Woodward
Journal: The Journal of Experimental Medicine (1897)

Colostrum corpuscles are not always found in so-called colostrum milk; when they are present, the percentage of proteids is higher; as they disappear, the proteid percentage drops. The color of colostrum milk is yellow; this color is especially marked in negroes' milk (observed in four cases not included in this report). The reaction of colostrum milk is alkaline. The specific gravity varies from 1024 to 1034. This variation is chiefly due to the variation in the amount of fat present.
Related Leucine-based Cytoplasmic Targeting Signals in Invariant Chain and Major Histocompatibility Complex Class II Molecules Control Endocytic Presentation of Distinct Determinants in a Single Protein
Authors: Guangming Zhong, Paola Romagnoli, Ronald N. Germain
Journal: The Journal of Experimental Medicine (1997)

Leucine-based signals in the cytoplasmic tail of invariant chain (Ii) control targeting of newly synthesized major histocompatibility complex class II molecules to the endocytic pathway for acquisition of antigenic peptides. Some protein determinants, however, do not require Ii for effective class II presentation, although endocytic processing is still necessary. Here we demonstrate that a dileucine-based signal in the cytoplasmic tail of the class II beta chain is critical for this Ii-independent presentation. Elimination or mutation of this signal reduces the rate of re-entry of mature surface class II molecules into the endocytic pathway. Antigen presentation controlled by this signal does not require newly synthesized class II molecules and appears to involve determinants requiring only limited proteolysis for exposure, whereas the opposite is true for li-dependent determinants. This demonstrates that related leucine-based trafficking signals in li and class II control the functional presentation of protein determinants with distinct processing requirements, suggesting that the peptide binding sites of newly synthesized versus mature class II molecules are made available for antigen binding in distinct endocytic compartments under the control of these homologous cytoplasmic signals. This permits capture of protein fragments produced optimally under distinct conditions of pH and proteolytic activity.
Bronchial needle aspiration in the diagnosis of bronchial carcinoma.
Authors: G Buirski, P M Calverley, N J Douglas, D Lamb, M McIntyre, M F Sudlow, H White
Journal: Thorax (1981)

Sixty consecutive patients with central bronchial carcinomas were studied by fibreoptic bronchoscopy. In all forceps biopsy and bronchial needle aspiration were performed, and in 54 bronchial brushings were obtained. The combination of bronchial brushings and forceps biopsy diagnosed bronchial carcinoma of a defined cell type in 80% of patients. Bronchial needle aspiration was the most effective single technique giving a cytological diagnosis in 80% of patients, and when all three techniques were combined the positive rate increased to 92%. No major complications occurred using bronchial needle aspiration. Needle aspiration was particularly helpful when sampling from lesions in the upper lobes where forceps biopsies were technically difficult, from tumours lying submucosally, and from abnormalities caused by extrinsic compression. We conclude that bronchial needle aspiration should be used routinely, together with other sampling techniques, in the diagnosis of central bronchial carcinoma with the fibreoptic bronchoscope.
THE NATIONAL RESEARCH COUNCIL AND MEDICAL PREPAREDNESS
Authors: LEWIS H. WEED
Journal: JAMA (1941)

It is now slightly over a year since the Division of Medical Sciences of the National Research Council established the first committees which were to act in an advisory capacity to the Surgeon Generals. The inauguration of this advisory activity came as a result of an initial request from Surg. Gen. James C. Magee that the division give advice about certain medical problems, particularly regarding the administration of the newer chemotherapeutic agents and regarding the treatment of surgical shock. This request of General Magee's was promptly discussed with the officers of the Medical Corps of the Navy and of the Public Health Service, and general agreement as to the desirability of such advisory committees was obtained. It seemed quite appropriate that the Division of Medical Sciences should be asked to serve in this advisory way to the armed services. The National Research Council was established in 1916 as the operating
The effect of acute changes in coronary blood flow on left ventricular end-diastolic wall thickness. An echocardiographic study.
Authors: W H Gaasch, S A Bernard
Journal: Circulation (1977)

The effect of acute alterations in coronary blood flow (CBF) on left ventricular (LV) end-diastolic wall thickness was measured by reflected ultrasound in twelve anesthetized dogs. During five minutes of coronary ligation, wall thickness decreased from a control of 9.0 +/- 0.3 mm to 8.1 +/- 0.3 mm (P less than 0.001); during reperfusion (reactive hyperemia), wall thickness was greater than control (10.2 +/- 0.2 mm at one minute, P less than 0.001). Increased CBF produced by intracoronary nitroglycerin or papaverine resulted in transient increases in wall thickness from 8.9 +/- 0.1 mm to 9.7 +/- 0.2 at one minute (P less than 0.001) and 10.0 +/- 0.6 mm to 11.2 +/- 0.7 mm at one minute (P less than 0.001), respectively. The observed direct relation between CBF and wall thickness suggests a dynamic role for CBF in calculations of LV mass, diastolic wall stress, and myocardial stiffness constants.