tbuckley/cabot-search huggingface dataset:
Should eponyms be abandoned? Yes
Authors: Alexander Woywodt, Eric Matteson
Journal: BMJ (2007)

Medicine has been enthusiastic in naming tests, symptoms, and diseases after their discoverers. <b>Alexander Woywodt</b> and <b>Eric Matteson</b> argue that eponyms are no longer appropriate, but <b>Judith A Whitworth </b>believes they remain a useful reflection of medical history
Nuclear Y-Box Binding Protein-1, a Predictive Marker of Prognosis, Is Correlated with Expression of HER2/ErbB2 and HER3/ErbB3 in Non-small Cell Lung Cancer
Authors: Masaki Kashihara, Koichi Azuma, Akihiko Kawahara, Yuji Basaki, Satoshi Hattori, Takashi Yanagawa, Yasuhiro Terazaki, Shinzo Takamori, Kazuo Shirouzu, Hisamichi Aizawa, Kenji Nakano, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono
Journal: Journal of Thoracic Oncology (2009)
Experimental Production of Aberrant Ventricular Conduction in Man
Authors: STAFFORD I. COHEN, SUN H. LAU, JACOB I. HAFT, ANTHONY N. DAMATO
Journal: Circulation (1967)

Aberrant ventricular conduction (AbC) was produced in 17 of 18 subjects, including six normal persons, by the introduction of electric stimuli via a transvenous catheter situated in the right atrium. Analysis of electrophysiological determinants indicated that AbC was favored by a long cycle preceding the short cycle which terminated in the aberrant complex, a short R to stimulus coupling interval, and fast atrioventricular conduction time. Electrocardiographic analysis of AbC revealed that all patients had right bundle-branch block (RBBB). In addition, incomplete right bundle-branch block was present in eight patients and was transformed to RBBB in all cases by shortening the coupling interval. Ten patients had slight but distinct variations of their RBBB pattern. There were two instances each of left bundle-branch block and intraventricular conduction disturbance. Hence, any patient may have the potential to produce a variety of AbC patterns. AbC was produced in six normal subjects and must be considered a physiological event which does not require covert pathology of the specialized conduction system.
Laboratory Test Handbook: With Key Word Index
Authors: H. Rochman
Journal: JAMA (1992)

This is more than a handbook. Its more than 1200 pages cover the ever-growing field of tests in pathology, with sections on clinical chemistry, coagulation, cytology, hematology, immunology, serology, microbiology, blood banking, virology, and toxicology. This extensive range inevitably requires the book to be multiauthored; fortunately, it is well edited with a most satisfactory style. The footnotes and key-word index are invaluable, references are pertinent and up to date, and concentrations of biochemical moieties are expressed in both conventional (US) and SI units. This comprehensive text is a must for pathologists and clinicians and is exceptionally moderately priced. Disadvantages? The type is just too small, particularly for readers in their sixth decade and older. Secondly, with our aging patient population, findings in elderly subjects and patients could have been discussed, eg, in the interpretation of results for thyroid function, glucose tolerance, and gastric acidity testing. Last, I doubt whether the
Respiratory and Other Health Effects Reported in Children Exposed to the World Trade Center Disaster of 11 September 2001
Authors: Pauline A. Thomas, Robert Brackbill, Lisa Thalji, Laura DiGrande, Sharon Campolucci, Lorna Thorpe, Kelly Henning
Journal: Environmental Health Perspectives (2008)

Effects of the World Trade Center (WTC) disaster on children's respiratory health have not been definitively established.This report describes respiratory health findings among children who were < 18 years of age on 11 September 2001 (9/11) and examine associations between disaster-related exposures and respiratory health.Children recruited for the WTC Health Registry (WTCHR) included child residents and students (kindergarten through 12th grade) in Manhattan south of Canal Street, children who were south of Chambers Street on 9/11, and adolescent disaster-related workers or volunteers. We collected data via computer-assisted telephone interviews in 2003-2004, with interview by adult proxy for children still < 18 years of age at that time. We compared age-specific asthma prevalence with National Health Interview Survey estimates.Among 3,184 children enrolled, 28% were < 5 years of age on 9/11; 34%, 5-11 years; and 39%, 12-17 years. Forty-five percent had a report of dust cloud exposure on 9/11. Half (53%) reported at least one new or worsened respiratory symptom, and 5.7% reported new asthma diagnoses. Before 9/11, age-specific asthma prevalence in enrolled children was similar to national estimates, but prevalence at interview was elevated among enrollees < 5 years of age. Dust cloud exposure was associated with new asthma diagnosis (adjusted odds ratio = 2.3; 95% confidence interval, 1.5-3.5).Asthma prevalence after 9/11 among WTCHR enrollees < 5 years of age was higher than national estimates, and new asthma diagnosis was associated with dust cloud exposure in all age groups. We will determine severity of asthma and persistence of other respiratory symptoms on follow-up surveys.
NICE recommends small improvements to help people stay at healthy weight
Authors: J. Wise
Journal: BMJ (2015)

<h3>Abstract</h3> Recent advances in long-read sequencing opened a possibility to address the long-standing questions about the architecture and evolution of human centromeres. They also emphasized the need for centromere annotation (partitioning human centromeres into monomers and higher-order repeats (HORs)). Even though there was a half-century-long series of semi-manual studies of centromere architecture, a rigorous centromere annotation algorithm is still lacking. Moreover, an automated centromere annotation is a prerequisite for studies of genetic diseases associated with centromeres, and evolutionary studies of centromeres across multiple species. Although the monomer decomposition (transforming a centromere into a monocentromere written in the monomer alphabet) and the HOR decomposition (representing a monocentromere in the alphabet of HORs) are currently viewed as two separate problems, we demonstrate that they should be integrated into a single framework in such a way that HOR (monomer) inference affects monomer (HOR) inference. We thus developed the HORmon algorithm that integrates the monomer/HOR inference and automatically generates the human monomers/HORs that are largely consistent with the previous semi-manual inference.
Comparison of oestradiol and prostaglandin E2 vaginal gel for ripening the unfavourable cervix
Authors: P M Tromans, J. M Beazley
Journal: BMJ (1981)

We thank Dr. D.J.R. Hutchon for his interesting comments and comparisons but we think it is fair to emphasize that our study did not exclude patients with nonengagement of the fetal head at term in whom minor cephalopelvic disproportion at the pelvic brim was suspected.  The mean birthweights and standard deviations for the estradiol and (PGE) prostaglandin E2 groups were 3.24 + or - 0.50 kg and 3.21 + or - 0.59 kg respectively.  There was no significant difference.  The cesarean section rate in patients in whom surgical induction of labor was feasible following treatment with estradiol or PGE2 was 18% and 15% respectively.  There were 7 patients in whom induction of labor was not feasible despite 2 treatments.  2 of these were then delivered by elective cesarean section for a combination of reasons.  In the other 5 patients labor was medically induced using an intravenous PGE2 infusion.  4 of these women were subsequently delivered by emergency cesarean section.  The post-gel cervical scores for the 2 spontaneously laboring patients were 10 and 13.  We believe that these high scores did not distort the statistical analysis because a nonparametric test was employed.  The duration of labor in these 2 patients was 11 hours and 1 hour respectively.  (Authors modified)
Abstract 3957: Identification of activated receptor tyrosine kinases in gastric cancer cells
Authors: Sang Hyun Yoon, Myung Eun Lee, Hei-Cheul Jeung, Jae-Joon Jung, Tae Soo Kim, Hyun Cheol Chung, Sang Joon Shin, Sun Young Rha
Journal: Cancer Research (2010)

Abstract To improve gastric cancer treatment, relevant molecular targets need to be identified. Receptor tyrosine kinases (RTKs) are multifunctional transmembrane proteins and important mediators of the signaling cascade, determining key roles in diverse biological processes like proliferation, growth, differentiation, and apoptosis of cancer cells. To determine if any of these RTKs are activated in gastric cancer, we performed phospho-receptor tyrosine kinase array with 25 gastric cancer cell lines using Human Phospho-RTK Antibody Proteome Profiler Array (R&amp;D Systems) which includes 42 different tyrosine kinases. Relative levels of tyrosine phosphorylation of RTKs among these cell lines were determined as a ratio relative to four positive phosphorylated tyrosine kinase control's intensity in each membrane. We found that various growth factor receptor tyrosine kinases were differentially activated and 15 of 42 RTKs were highly activated with mean intensity &amp;gt;5 among 25 gastric cancer cell lines. The highly activated RTKs were: EGFR (93.2), ErbB2 (33.0), HGFR (27.6), ErbB3 (26.2), IGF-IR (17.2), InsulinR (13.9), Mer (12.9), FGFR2α (11.4), Dtk (10.1), EphA7 (9.5), Tie-2 (8.9), MSPR (6.5), c-Ret (6.4), FGFR3 (5.4), and ErbB4 (5.1). These receptors basically belong to the EGF, HGF, FGF, Insulin, Tie, and Ephrin growth factor gene families_all of which are involved in cell proliferation, differentiation or signal transduction. We confirmed that increased RTKs phosphorylation observed by RTK array analysis was correlated with the expression level of each protein by immunoblotting. Additionally, we showed that Met gene amplification by quantitative real-time PCR is associated with Met activation in gastric cancer cell lines. In conclusion, these activated RTKs may work as potential therapeutic targets in gastric cancer and helpful to understand the molecular mechanisms underlying tumor development. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3957.
Prevalence and Titer of Specific IgE Antibodies in Relation to Total Serum IgE: Evaluation of Sensitization to Allergens Derived from Domestic Mice
Authors: L. Naccara, P. Heymann, M. Carter, A. Litonjua, E. Peters, S. Satinover, E. Erwin, T.A.E. Platts-Mills
Journal: Journal of Allergy and Clinical Immunology (2007)
Raised serum urate concentration as risk factor for premature mortality in middle aged men: relation to death from cancer.
Authors: B Petersson, E Trell
Journal: BMJ (1983)

Low serum cholesterol concentrations are associated with deaths from cancer. This association was found in a prospective study of middle aged men in Malmö and consideration of possible explanations for the lowering of serum cholesterol prompted an analysis of serum urate in relation to deaths from cancer. A total of 127 of the 7725 participants in the Malmö study had died since screening. A weakly positive but significant correlation between raised serum urate concentration and total mortality was found. This correlation was wholly explained by neoplastic deaths (p less than 0.01), while there were no associations with alcohol related deaths or with deaths from coronary heart disease. When the deaths from cancer were classified as "early" or "late"--that is, occurring less than or more than 2.5 years after the screening--the correlation between raised urate concentrations and cancer mortality was confined to the "early" deaths (p less than 0.001). Further studies are needed to substantiate the relation between raised serum urate concentrations and fatal neoplasia. Nevertheless, these findings weigh against recent suggestions that uric acid has an antioxidant protective effect against cancer.
The genetics of primary biliary cirrhosis: The revolution moves on
Authors: David E. J. Jones, George Mells
Journal: Hepatology (2011)

We genotyped individuals with primary biliary cirrhosis and unaffected controls for suggestive risk loci (genome-wide association P < 1 × 10−4) identified in a previous genome-wide association study. Combined analysis of the genome-wide association and replication datasets identified IRF5-TNPO3 (combined P = 8.66 × 10−13), 17q12-21 (combined P = 3.50 × 10−13) and MMEL1 (combined P = 3.15 × 10−8) as new primary biliary cirrhosis susceptibility loci. Fine-mapping studies showed that a single variant accounts for the IRF5-TNPO3 association. As these loci are implicated in other autoimmune conditions, these findings confirm genetic overlap among such diseases.
Plexogenic pulmonary arteriopathy and liver cirrhosis.
Authors: J R Ruttner, J P Bartschi, R Niedermann, J Schneider
Journal: Thorax (1980)

Primary pulmonary hypertension with plexiform vascular changes in the lungs and liver cirrhosis is a rare combination of unclear pathogenesis. Until now, the real prevalence has not been known. The diagnosis of this association is usually made retrospectively. The criteria are morphological--that is, right ventricular hypertrophy and the characteristic pulmonary arterial lesions, as well as clinical--based on ECG and chest radiography. Between 1970 and 1977, two such cases have been found among a total of 11988 necropsies performed on adults. In the same necropsy series, 765 cases of liver cirrhosis were found. The prevalence of this combination is 0.26% of the cirrhosis and 0.016% of all necropsies of adults. This low prevalence raises serious doubts as to whether the association is more than coincidental.
Augusta Dejerine-Klumpke
Authors: JULIUS BAUER
Journal: Annals of Internal Medicine (1974)

Comments1 July 1974Augusta Dejerine-KlumpkeJULIUS BAUER, M.D.JULIUS BAUER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-128_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nobody could have enjoyed Richard Satran's interesting biography of Mme. Klumpke more than I (Ann Intern Med 80:260-264, 1974).In 1914, before World War I, she was President of the French Neurological Society; she was one of its original members. Probably I am one of the few survivors who attended and remembers a solemn meeting of the Society and admired its president. With a fellowship granted by French and Austrian (Vienna) universities, I was at that time a student of Augusta's husband, Professor Jules Dejerine. Their daughter was a teenager who later became Mme. Y. Sorrel-Dejerine, when... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JULIUS BAUER, M.D.Affiliations: 615 North Bedford Dr. Beverly Hills, California 90210 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byScapula nach geburtstraumatischer PlexusläsionFigures and institutions of the neurological sciences in Paris from 1800 to 1950. Part III: Neurology 1 July 1974Volume 81, Issue 1Page: 128-128KeywordsAdolescentsFellowships ePublished: 1 December 2008 Issue Published: 1 July 1974 PDF downloadLoading ...
Workshop Affirms Value of Breast Conserving Treatments
Authors: K. Smigel
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Workshop Affirms Value of Breast Conserving Treatments Get access Kara Smigel Kara Smigel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 24, 21 December 1994, Pages 1824–1825, https://doi.org/10.1093/jnci/86.24.1824 Published: 21 December 1994
Blindness after treatment for malignant hypertension.
Authors: D H Cove, M Seddon, R F Fletcher, D C Dukes
Journal: BMJ (1979)

attacks.Oestrogens may increase the plasma concentrations of some of the coagulation factors with shortening of the prothrombin time.Toy et al2 found this effect with synthetic oestrogens but not with "natural" oestrogen (oestriol succinate).Thus it is improbable that this mechanism was responsible for thromboembolic episodes in our patient.The oestrogen preparation she was taking was a naturally occurring one (conjugated equine oestrogen), and the patient's prothrombin times remained within the therapeutic range, at levels similar to those maintained in the past without embolic symptoms.An increase in platelet adhesiveness, which can be shown during oestrogen therapy,3 was probably responsible for the appearance of embolic phenomena in our patient.The importance of platelets in the genesis of emboli from prosthetic heart valves is further illustrated by reports that patients being treated with dipyridamole in addition to oral anticoagulants derive greater protection from non- fatal thromboembolism than those taking anticoagulants alone.4In an extensive review of reports on oestrogen treatment in postmenopausal women, Shoemaker et a15 concluded that there was no proved risk of thromboembolic disease on such treatment.While this may be true for most women, it does not necessarily apply in those with an additional predisposing factor, such as a prosthetic heart valve.Our case illustrates the potential risks of oestrogen therapy in patients with valve prostheses.Anticoagulation with warfarin or phenindione alone should not be considered to protect these patients adequately against thromboembolic complications of oestrogen treatment.Non-essential oestrogen administration should be avoided in all patients with prosthetic heart valves.We are grateful to Dr J P Lee-Potter for providing haematological data, and to Mrs B Davies for her help in preparing this paper.
Design and Rationale of a Randomised Comparison of Cyclophosphamide, Methotrexate and Fluorouracil vs Fluorouracil, Epirubicin and Cyclophosphamide in Node-Positive Premenopausal Women with Operable Breast Cancer
Authors: J. Wils, R.C. Coombes, M. Marty, J. Bliss, E. Woods
Journal: Drugs (1993)
Find your voice and use it
Authors: Fiona Godlee
Journal: BMJ (2005)

across the world, argues Timimi on p 37.She warns that a Western value system that promotes individualism, weakens social ties, and creates ambivalence towards children could adversely affect children's mental health.On the other hand, values found in many non-Western cultures, such as duty, responsibility, and a community orientation, may promote psychiatric wellbeing.
Love Is the Best Doctor
Authors: Hector O. Ventura
Journal: Annals of Internal Medicine (1994)

Ad Libitum15 May 1994Love Is the Best DoctorHector O. Ventura, MD and Franz H. Messerli, MDHector O. Ventura, MDOchsner Medical Institutions, New Orleans, LA 70121.Search for more papers by this author and Franz H. Messerli, MDOchsner Medical Institutions, New Orleans, LA 70121.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-10-199405150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I had really become quite frustrated with Lisette's case. My colleague Franz and I had been seeing her since her husband died 5 years earlier. She had complained of everything: aching joints, low-back pain, shortness of breath, ingrown toenails. But most of all—“tiredness”. Not just tiredness, but “pain all over the body and tiredness”.I examined her each time she came for a checkup. I did her blood work. I listened to her heart. I took her blood pressure. And each time, the results were the same—everything was normal.“But I am tired, doctor, and I do have pain everywhere,” ... Author, Article, and Disclosure InformationAffiliations: Ochsner Medical Institutions, New Orleans, LA 70121. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1994Volume 120, Issue 10Page: 890KeywordsArthralgiaBloodBlood pressureDyspneaHeartPain ePublished: 15 August 2000 Issue Published: 15 May 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sodium channel blockers and uridine triphosphate: effects on nasal potential difference in cystic fibrosis mice
Authors: S. Ghosal, C.J. Taylor, W.H. Colledge, R. Ratcliff, M.J. Evans
Journal: European Respiratory Journal (2000)

Sodium channel inhibitors block the enhanced Na+ reabsorption in cystic fibrosis (CF). Extracellular nucleotides facilitate Cl- secretion via Ca2+ gated Cl- channels. A combination of these effects may produce less viscid secretions in CF which are easier to expectorate. This study examined the effects of combining sodium channel blockers with uridine triphosphate (UTP) on nasal membrane potential difference (PD) in CF insertional null mutant mice (cftr(tm1HGU)), deltaF508 homozygous mice (cftr(tm1Cam)) and matched control animals. Median basal PD in the insertional CF mice and deltaF508 CF mice were -28 and -34 mV respectively. These values were significantly different to the control animals (-20 mV). Amiloride and loperamide reduced the PD in cftr(tm1HGU) CF mice (deltaPD 13 mV &amp; 15 mV respectively) suggesting Na+ blockade. The subsequent addition of UTP in a chloride-free vehicle increased the PD (deltaPD -8- -12.5 mV). DeltaF508 mice showed significantly greater responses compared with CF insertional null mutant mice (p&lt;0.05). The action of UTP was brief and not prolonged by the addition alpha-beta-methylene-adenosine 59 diphosphate. Suramin, a competitive antagonist of P2 purinoceptors blocked the action of UTP. In conclusion, this study demonstrated dose dependant nasal membrane potential changes in differences mice with uridine triphosphate in the presence of sodium channel blockers suggestive of chloride secretion. More stable analogues of uridine triphosphate in combination with long acting sodium channel blockers such as loperamide may have therapeutic potential in cystic fibrosis.
Evaluation of Light Exercise in the Treatment of Gestational Diabetes
Authors: Apolonia García-Patterson, Esther Martín, Justa Ubeda, Miguel Angel María, Alberto de Leiva, Rosa Corcoy
Journal: Diabetes Care (2001)

The metabolic goal of therapy in gestational diabetes (GD) is to maintain euglycemia, and when it is not achieved with diet alone, insulin therapy is added (1). Physical training has both acute and long-term effects on insulin sensitivity, insulin secretion, and glucose metabolism in both nondiabetic and diabetic subjects (2), and the benefit of training has also been shown in patients with GD, where controlled training achieves euglycemia with no need for insulin treatment (3). Nevertheless, physical exercise of moderate intensity has been associated with uterine contractions unless performed with the arms (4).

The clinical observation that light postprandial exercise …