tbuckley/cabot-search huggingface dataset:
Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis Testis
Authors: Yves Chollet, Philippe Hauser, Telma Da Silva, Jean-Yves Meuwly, Valentin Praz, Patrice Jichlinski, Louis Guillou, Angelika Bischof Delaloye, Marc Wisard, John Prior
Journal: Clinical Nuclear Medicine (2008)

An 18-year-old man presented with a growing painless left scrotal mass. Sonography showed a hydrocele and a homogeneous, well-encapsulated left extratesticular mass with similar echogenicity as the normal testis, suggestive of a splenogonadal fusion. To substantiate the diagnosis, the patient underwent Tc-99m heat-denatured red blood cell scintigraphy showing normal physiological hyperactivity in the spleen but activity similar to the blood pool projecting on the upper part of the left testis. This made testicular splenic tissue less likely. The patient underwent resection and histopathology revealed a well-differentiated papillary mesothelioma. Inguinal orchidectomy was subsequently performed and the patient was free of recurrence at 18 months.
1127-107 Different criteria of cardiac resynchronization therapy have different prognostic value for worsening heart failure or major arrhythmic events in idiopathic dilated cardiomyopathy
Authors: Laurent Fauchier, Julien Douglas, Dominique Babuty, Oliveir Marie, Pierre Cosnay, Pierre Bonnet, Jean Paul Fauchier
Journal: Journal of the American College of Cardiology (2004)
Diabetics and motorway crashes.
Authors: N Santer
Journal: BMJ (1972)

idealistic perfection, our's of the practical care of children.Finally, a standard dosage regimen recom- mended for nitrofurantoin is 7 mg/kg/24 hours.'For a 2-year-old weighing approximately 12 kg 75 mg per day is not excessive.Not being blessed with foresight, we were not able to foresee the results firom Professor de Wardener's department that Dr. Bailey refers to,2 as these had not been published at the time we draf:ed our article, let alone at the time we were treating the child con- oerned.-Weare, etc.,
Antiphospholipid antibodies impact the protein C (PC) pathway behavior
Authors: Laura C. Gennari, Alicia N. Blanco, María Fabiana Alberto, Silvia H. Grosso, Andrea A. Peirano, Maria A. Lazzari
Journal: American Journal of Hematology (2002)

Antiphospholipid antibodies may interfere with the PC pathway, displaying a resistance to the activated PC (resistant phenotype). This effect was evaluated by the APCR and the ProCG systems in 36 lupus anticoagulant samples, yielding abnormal results in 47% of APCR(original), 17% of APCR(modified), and 22% of ProCG test. ProCG values correlated with APCR(original) but not with APCR(modified). Most of lupus anticoagulants affecting the PC pathway showed abnormal APCR(original) results but not abnormal ProCG values. The different behavior between both systems may be due to the heterogeneity of the antibodies or could be attributed to the fact that, in the ProCG, a PC activator is added, while the APCR employs already activated exogenous PC.
Paraneoplastic follicular hyperkeratosis responsive to etretinate
Authors: Frances Humphreys, Jane Spencer, Claire Benton
Journal: British Journal of Dermatology (1992)

Journal Article Paraneoplastic follicular hyperkeratosis responsive to etretinate Get access Frances Humphreys, Frances Humphreys University Department of Dermatology, The Royal Infirmary, Edinburgh EH3 9YW, U.K. Search for other works by this author on: Oxford Academic Google Scholar Jane Spencer, Jane Spencer University Department of Dermatology, The Royal Infirmary, Edinburgh EH3 9YW, U.K. Search for other works by this author on: Oxford Academic Google Scholar Claire Benton Claire Benton University Department of Dermatology, The Royal Infirmary, Edinburgh EH3 9YW, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 1, 1 July 1992, Pages 62–63, https://doi.org/10.1111/j.1365-2133.1992.tb14831.x Published: 01 July 1992
Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis.
Authors: D Walmrath, T Schneider, J Pilch, R Schermuly, F Grimminger, W Seeger
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The effects of aerosolized prostaglandin (PG) I2 on gas exchange and hemodynamics were investigated in patients ventilated mechanically because of severe community-acquired pneumonia. Group A were patients without preexisting lung disease (n = 6), and Group B were those with underlying chronic fibrotic interstitial lung disease (n = 6). Ventilation-perfusion distribution was assessed by the multiple inert gas elimination technique. In Group A, low doses of aerosolized PGI2 (mean, 6.6 +/- 3.0 ng/kg/min) sufficed to decrease the mean pulmonary artery pressure (Ppa) from 35.0 +/- 1.5 to 31.0 +/- 1.6 mm Hg (p < 0.05), to improve the ratio of arterial oxygen to the fraction of inspired oxygen (PaO2/FIO2 increase from 100 +/- 18 to 134 +/- 18; p < 0.05), and to decrease intrapulmonary shunt (36.9 +/- 4.7 to 27.5 +/- 4.5%; p < 0.05). Systemic arterial pressure (Psa) and cardiac output remained unchanged. In Group B, aerosolized PGI2 was ineffective in doses less than 10 ng/kg/min. A dosage of 33.6 +/- 12 ng/kg/min reduced Ppa (38.0 +/- 2.4 to 30.8 +/- 2.1 mm Hg; p < 0.05), but it also decreased Psa (80.3 +/- 3.6 to 71.3 +/- 4.7 mm Hg; NS) and PaO2/FIO2 (73.8 +/- 6.6 to 65.5 +/- 6.8 mm Hg; p < 0.05) values and increased intrapulmonary shunt (44.7 +/- 3.0 to 49.4 +/- 5.0%, NS). After withdrawal of the PGI2 aerosol, all gas exchange and hemodynamic changes returned to preaerosol baseline values within 60 min in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Rapid Determination of Glomerular Filtration Rate in Infants Using Tc-99m DTPA
Authors: K C SEKAR, J C LEONARD, W R PUFFINBURGER, D M BUROW, J C DUKE
Journal: Clinical Nuclear Medicine (1992)

Glomerular filtration rate obtained by using Tc-99m DTPA was compared with that obtained from Schwartz's formula using serum creatinine and length in 21 infants (age range, 3 to 348 days). The GFR (mean +/- SD) obtained by Tc-99m DTPA was 76 +/- 37 ml/min per 1.73m2 and by the Schwartz formula was 83 +/- 49 ml/min per 1.73m2. GFR by Tc-99m DTPA method overestimated GFR by 3.6% compared to the Schwartz method. The imaging technique and the advantages are discussed.
Natural Tissue Engineering Inside a Ventricular Septum Defect Occluder
Authors: Helge Möllmann, Holger M. Nef, Sawa Kostin, Woitek Skwara, Jutta Schaper, Christian W. Hamm, Albrecht Elsässer
Journal: Circulation (2006)

E ighteen days after having received conservative treat- ment for a myocardial infarction, a 65-year-old patient developed acute right heart failure caused by a ventricular septal rupture.Progressive multiorgan failure contraindicated open heart surgery.Therefore, we implanted a ventricular septal defect occluder via a venous approach as an emergency intervention, thereby achieving stabilization of the patient within 24 hours.After another 6 weeks, an aneurysmectomy was planned because a remarkable aneurysm of the anterior wall, including the part of the septum in which the occluder was located, was detected by echocardiography and magnetic resonance imaging.During open heart surgery, the occluder was removed (Figure 1), and a Dor procedure was performed in addition to aortocoronary bypass grafting.After accurately cutting through the occluder, an immunohistochemistry study was performed (Figure 2).Tissue formation was observed on the nitinol arms of the occluder.The boundaries of this newly formed tissue were mainly defined by smooth muscle cells.The portion of tissue extending to the left ventricle was more multilayered Disclosures
BLINDNESS AND OCULOMOTOR PALSIES FROM INJURIES NOT INVOLVING THE OPTIC OR OCULOMOTOR NERVES.
Authors: ALVIN A. HUBBELL
Journal: JAMA (1905)

That the eye in its visual function and motility is disturbed by causes remote from it, has been known for centuries, and is also a matter of common observation to-day. Among these disturbing causes have been found certain injuries about the face and forehead, which have led to partial or complete loss of vision, usually of one eye, and paralysis, partial or complete, of some of the ocular nerves, these injuries not seeming to involve the particular nerves whose function was impaired or lost. In a large proportion of these cases the injuries have apparently been limited to the fifth nerve, or some of its branches. Hippocrates had noticed this, and it is recorded that he said "the sight is obscured in wounds which are inflicted on the eyebrow or a little higher."<sup>1</sup> Blindness and ocular palsies following violent injuries of the face and head, and direct injuries of the optic and
Hormone receptors in breast cancer.
Authors: M Sluyser
Journal: BMJ (1978)

tactics summed up by Stevenson in his book Ethics and Language.'Teachers may resort to emotive techniques in order to change the attitudes of children towards various methods of behaviour.It is my opinion, however, that any attempt at crude emotivism will fail.We should present the children with the medical facts against a background of caring, now about their parents, later about their dependants.
Hormone replacement therapy and risk of venous thromboembolism: population based case-control study
Authors: S. P. Gutthann, L. A G. Rodriguez, J. Castellsague, A. D. Oliart
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To evaluate the association between use of hormone replacement therapy and the risk of idiopathic venous thromboembolism. <b>Design:</b> Population based case-control study. <b>Setting:</b> Population enrolled in the General Practice Research Database, United Kingdom. <b>Subjects:</b> A cohort of 347 253 women aged 50 to 79 without major risk factors for venous thromboembolism was identified. Cases were 292 women admitted to hospital for a first episode of pulmonary embolism or deep venous thrombosis; 10 000 controls were randomly selected from the source cohort. <b>Main outcome measures:</b> Adjusted relative risks estimated from unconditional logistic regression. <b>Results:</b> The adjusted odds ratio of venous thromboembolism for current use of hormone replacement therapy compared with non-users was 2.1 (95% confidence interval 1.4 to 3.2). This increased risk was restricted to first year users, with odds ratios of 4.6 (2.5 to 8.4) during the first six months and 3.0 (1.4 to 6.5) 6-12 months after starting treatment. No major risk differences were observed between users of low and high doses of oestrogens, unopposed and opposed treatment, and oral and transdermal preparations. The risk of idiopathic venous thromboembolism among non-users of replacement therapy was estimated to be 1.3 per 10 000 women per year. Among current users, idiopathic venous thromboembolism occurs at two to three times the rate in non-users, resulting in one to two additional cases per 10 000 women per year. <b>Conclusions:</b> Current use of hormone replacement therapy was associated with a higher risk of venous thromboembolism, although the risk seemed to be restricted to the first year of use.
Sydney Ringer viewed in a new light
Authors: C. H Orchard, D. A Eisner, D. G Allen
Journal: Cardiovascular Research (1994)

Journal Article Sydney Ringer viewed in a new light Get access Clive H Orchard, Clive H Orchard Department of Physiology, University College London, London WC1, United Kingdom: C H Orchard, D A Eisner, D G Allen. Correspondence to Dr Orchard, at Department of Physiology, University of Leeds, Leeds LS2 9JT, United Kingdom. Search for other works by this author on: Oxford Academic PubMed Google Scholar David A Eisner, David A Eisner Department of Physiology, University College London, London WC1, United Kingdom: C H Orchard, D A Eisner, D G Allen. Search for other works by this author on: Oxford Academic PubMed Google Scholar David G Allen David G Allen Department of Physiology, University College London, London WC1, United Kingdom: C H Orchard, D A Eisner, D G Allen. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 12, December 1994, Pages 1765–1768, https://doi.org/10.1093/cvr/28.12.1765 Published: 01 December 1994 Article history Received: 28 July 1994 Published: 01 December 1994
Selective Adhesion-Molecule Therapy and Inflammatory Bowel Disease — A Tale of Janus?
Authors: Daniel K. Podolsky
Journal: New England Journal of Medicine (2005)

Although our understanding of the pathogenesis of the chief forms of inflammatory bowel disease, Crohn's disease, and ulcerative colitis remains incomplete, progress is being made in identifying essential components.1 The presence of large numbers of varied leukocytes within affected tissue where they are normally sparse makes it axiomatic that active disease is dependent on the recruitment of these cell populations. Recruitment is now known to proceed through a stereotypical series of steps that depend on selective adhesion molecules (SAMs). These include cell-surface integrins, heterodimers formed by various combinations of α and β subunits. Integrins with an α4 chain appear . . .
Child and Adolescent Development: Clinical lmplications
Authors: Gentry W. Yeatman
Journal: JAMA (1990)

This is a short book with a 130-page introduction that takes up almost 40% of the written material. It has brief chapters covering fetal through late adolescent growth and development. It could best be described as an overview of an incredibly vast amount of material, but not in enough detail to qualify as a practical text or a comprehensive reference.  I find it to be interesting reading but mostly covering material available in other sources and lacking any originality in its style of presentation. It does contain valuable material for medical students who are rotating through general pediatrics, adolescent medicine, or developmental pediatrics, although not as a required primary text.  I find the chapter on fetal development sufficiently convincing that we are dealing with indispensable humanity and not disposable amorphous tissue. In the chapter on the newborn it is fascinating to discover what an intelligent infant, with memory and preferences,
Reye's syndrome, salicylates, epidemiology, and public health policy
Authors: E. A. Mortimer
Journal: JAMA (1987)

A report in this issue ofThe Journal 1 is the fifth major publication to implicate salicylates in the pathogenesis of Reye's syndrome (RS). This report confirms and strengthens prior observations, 2-5 and I would recommend that attention now turn to such unanswered questions as the pathogenesis of the relationship and why RS occurs primarily with influenza and varicella and rarely with other infections.  The first reasonably conclusive evidence of an association and a tentative warning appeared in 1980, 6 but no definitive action was taken until 1986. During 1981 through 1985, one thousand three cases of RS with 291 deaths were reported to the Centers for Disease Control 7 ; it is likely that up to a third of survivors incurred permanent brain damage. In 1985 only 91 cases were reported, probably attributable to a decline in aspirin use for children. 8 Most epidemiologists who reviewed the three initial reports
Observations on the effect of immersion in Bath spa water.
Authors: J P O'Hare, A Heywood, C Summerhayes, G Lunn, J M Evans, G Walters, R J Corrall, P A Dieppe
Journal: BMJ (1985)

Immersion in water in spas has been practised for centuries and has many proponents. Despite fierce debate about its efficacy there has been little scientific evaluation of the effect of immersion in mineral waters. Eight normal subjects were immersed in Bath spa water for two hours and the renal, haematological, and cardiovascular responses were compared with those in the control periods before and after immersion. Significant, twofold diuresis and natriuresis, 5% haemodilution, and a 50% increase in cardiac index were observed in subjects immersed, sitting, in Bath spa water at 35 degrees C. These changes may constitute part of the scientific rationale for spa treatment in many states of disease.
The Lilly Lecture: Biliary Secretory Failure in Man: The Problem of Cholestasis.
Authors: Sheila Sherlock
Journal: Annals of Internal Medicine (1966)

s1 May 1966The Lilly Lecture: Biliary Secretory Failure in Man: The Problem of Cholestasis.Sheila Sherlock, F.R.C.P.(E)Sheila Sherlock, F.R.C.P.(E)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1162_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis syndrome occurs at all levels in the liver cell and intrahepatic bile duct system. It is of various types. The genetic group includes the Dubin-Johnson type of conjugated hyperbilirubinemia.Drugs such as norethandrolone or methyl testosterone cause a canalicular type of cholestasis, and the relationship of this to the use of contraceptive drugs will be discussed. The idiopathic jaundice of the last trimester of pregnancy seems to be of similar type. Patients who have a predisposition to this condition and who take contraceptive pills are liable to become jaundiced. Other drugs cause cholestasis as part of a sensitivity reaction,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Sheila Sherlock, F.R.C.P.(E)Affiliations: London, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1162-1162KeywordsBile ductsContraceptivesDrugsGeneticsLiverPregnancyTestosterone ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...
Transvenous biopsy of orthotopic liver grafts: Feasible and effective
Authors: A. Hadenoue, D. Lebrec, C. Gaudin, J. Bernauau, J. Belghiti, B Gayet, C. Degott, J.-F. Flejou, S. Erlinger, J.-P. Benhamou
Journal: Journal of Hepatology (1990)
Murder he wrote
Authors: Theodore Dalrymple
Journal: BMJ (2007)

There have been many doctors who murdered, but few who did so who reached the top of the profession—the medical profession, that is. Oddly enough, Robert Louis Stevenson seems, in his short story The Body-Snatcher , to accuse Sir William Fergusson, professor of Surgery at King's College Hospital, and surgeon to Queen Victoria, of having been both an accessory to murder, and a murderer, in his youth.

In the story, a degenerate doctor called Fettes meets by chance a successful, rich, and eminent London practitioner called Wolfe Macfarlane. It turns out that they knew each other when both were students in Edinburgh, and both were assistants to Mr K, a private teacher of anatomy there. They both took delivery …
Commissioners publish highly critical reports on mental health services
Authors: L. Eaton
Journal: BMJ (2009)

The poor standards of care and supervision of people with severe mental health problems in NHS hospitals in England have come under the spotlight in two damning reports issued by the Care Quality Commission, which recently took over the work of the Mental Health Act Commission.

Coercion and Consent , the 13th (and final) report of the now defunct Mental Health Act Commission, looks at services throughout England and Wales between 2007 and 2009. It also looked at the causes of the 1392 deaths of detained patients between 2005 and 2008.

Of these deaths, 1123 were ascribed to natural causes, 205 to suicide, 30 to accidental causes, two to incorrect medication, and four to the intervention of a doctor (iatrogenic). The causes of death were unknown in 28 cases.

In one …
A Statutory Definition Of Death in Kansas
Authors: Loren F. Taylor
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Kansas has led the United States in the adoption of organ donation laws. Kansas adopted the Uniform Anatomical Gift Act in 1968, about six months before the Joint Commission on Uniform State Laws approved its own final draft of the proposed legislation. Later, the 1969 Kansas Legislature amended the Anatomical Gift Act to conform to the Act as promulgated by the Joint Commission. In a case in 1967 (<i>United Trust vs Pyke</i>, 199 Kan 1,4,427 P 2d 67,71), a Kansas court accepted a 16th century definition of death: "Death is the cessation of all vital functions without possibility of resuscitation." With the passing of the Uniform Anatomical Gift Act, Kansas became the only state with comprehensive, enabling legislation for procuring organs for transplantation, at nearly the same time case law was interpreted as specifically precluding organ transplantation, at least where the donated organ was to be removed
The Predictive Value of Serum Haptoglobin in Hemolytic Disease
Authors: Anthony Marchand
Journal: JAMA (1980)

Using a rapid, highly sensitive immunoprecipitin nephelometric technique, a retrospective study was undertaken to evaluate the clinical usefulness of determining serum haptoglobin in the diagnosis of hemolysis. Haptoglobin assays were performed shortly after admission in 100 patients with a variety of hematologic and nonhematologic conditions and the results correlated with the clinical diagnosis. An ad hoc boolean computer program allowed for the separation of hemolytic from nonhemolytic disorders with a haptoglobin limit of 25 mg/dL or less. The sensitivity and specificity of the test are high (83% and 96%, respectively), providing 87% probability of predicting hemolytic disease when the serum haptoglobin level falls below this limit. These data support the routine use of serum haptoglobin determinations in the diagnosis of hemolytic disease. (<i>JAMA</i>243:1909-1911, 1980)
Interferon regulatory factor-3 activation, hepatic interferon-stimulated gene expression, and immune cell infiltration in hepatitis C virus patients
Authors: Daryl T.-Y. Lau, Penny Mar Fish, Mala Sinha, David M. Owen, Stanley M. Lemon, Michael Gale
Journal: Hepatology (2008)

Interferon regulatory factor-3 (IRF-3) activation directs α/β interferon production and interferon-stimulated gene (ISG) expression, which limits virus infection. Here, we examined the distribution of hepatitis C virus (HCV) nonstructural 3 protein, the status of IRF-3 activation, and expression of IRF-3 target genes and ISGs during asynchronous HCV infection in vitro and in liver biopsies from patients with chronic HCV infection, using confocal microscopy and functional genomics approaches. In general, asynchronous infection with HCV stimulated a low-frequency and transient IRF-3 activation within responsive cells in vitro that was associated with cell-to-cell virus spread. Similarly, a subset of HCV patients exhibited the nuclear, active form of IRF-3 in hepatocytes and an associated increase in IRF-3 target gene expression in hepatic tissue. Moreover, ISG expression profiles formed disease-specific clusters for HCV and control nonalcoholic fatty liver disease patients, with increased ISG expression among the HCV patients. We identified the presence of T cell and plasmacytoid dendritic cell infiltrates within all biopsy specimens, suggesting they could be a source of hepatic interferon in the setting of hepatitis C and chronic inflammatory condition. Conclusion: These results indicate that HCV can transiently trigger IRF-3 activation during virus spread and that in chronic HCV, IRF-3 activation within infected hepatocytes occurs but is limited.
Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
Authors: Florencia Cayrol, María Celeste Díaz Flaqué, Tharu Fernando, Shao Ning Yang, Helena Andrea Sterle, Marcela Bolontrade, Mariana Amorós, Blanca Isse, Ricardo Norberto Farías, Haelee Ahn, Ye F. Tian, Fabrizio Tabbò, Ankur Singh, Giorgio Inghirami, Leandro Cerchietti, Graciela Alicia Cremaschi
Journal: Blood (2014)