Transfusion-Associated <i>Trypanosoma cruzi</i> Infection in a Non-Endemic Area
Authors: Peter Nickerson, Pamela Orr, Maria-Louise Schroeder, Leila Sekla, James B. Johnston
Journal: Annals of Internal Medicine (1989)

Brief Reports15 November 1989Transfusion-Associated Trypanosoma cruzi Infection in a Non-Endemic AreaPeter Nickerson, MD, Pamela Orr, MD, Maria-Louise Schroeder, MD, Leila Sekla, MD, James B. Johnston, MDPeter Nickerson, MD, Pamela Orr, MD, Maria-Louise Schroeder, MD, Leila Sekla, MD, James B. Johnston, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-10-851 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOpportunistic infections have become a major cause of morbidity in the immunocompromised host. In patients with neutropenia, such infections often arise from their own indigenous flora; however, another potential mode of infection is the transmission of blood-borne organisms by transfusions. Patients with granulocytopenia who receive multiple blood products during chemotherapy are especially prone to transfusion-associated infections. We describe the first case of transfusion-associated acute Chagas disease in a nonendemic area of North America.Case ReportIn June 1986, a 1-year-old infant presented with a cerebral thrombosis and was subsequently found to have protein S deficiency. When the family was screened,...References1. Hudson L and Hay F. Practical Immunology. Oxford: Black well Scientific Publications; 1980. Google Scholar2. Kohl S, Pickering L, Frankel L, and Yaeger R. Reactivation of Chagas' disease during therapy of acute lymphocytic leukemia. Cancer. 1982;50:827-8. CrossrefMedlineGoogle Scholar3. Amato Neto V, Molinari H, Siqueira A, and Lucas R. Análise, por meio de reaçãe de fixação do complemento, do risco de aquisicao da doença de Chagas através de hemoterapia, por parte de pacientes politransfundidos. Revista Goiana de Medicina. 1975;21:1-9. Google Scholar4. Mattosinho-Franca L, Lemos S, and Fleury R. Moléstia de Chagas cronica associada a leucemia linfática. Ocorrencia de encefalite aguda como alteração do estado imunitàrio. Archivas de Neuropsiquiatria. 1969;27:59-66. CrossrefGoogle Scholar5. Kirchhoff L, Gam A, and Gilliam F. American trypanosomiasis (Chagas' disease) in Central American immigrants. Am J Med. 1987;82:915-20. CrossrefMedlineGoogle Scholar6. Gutteridge W. Existing chemotherapy and its limitations. Br Med Bull. 1985;42:162-8. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Peter Nickerson, MD; Pamela Orr, MD; Maria-Louise Schroeder, MD; Leila Sekla, MD; James B. Johnston, MDFrom the University of Manitoba, the Canadian Red Cross, and the Cadham Provincial Laboratory; Winnipeg, Manitoba, Canada. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProtozoan phagotrophy from predators to parasites: An overview of the enigmatic cytostome‐cytopharynx complex of Trypanosoma cruziWorldwide Control and Management of Chagas Disease in a New Era of Globalization: a Close Look at Congenital Trypanosoma cruzi InfectionInternational survey of strategies to mitigate t ransfusion‐transmittedTrypanosoma cruzi in n on‐endemic countries, 2016–2018Trypanocidal drugs for late-stage, symptomatic Chagas disease ( Trypanosoma cruzi infection)Promising trypanocidal heterocyclic compounds of natural origin and their synthetic analogsSeroprevalence of Trypanosoma cruzi infection among at‐risk blood donors in JapanHematologic Aspects of Parasitic DiseasesDiscovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruziFrequency of Trypanosoma cruzi parasitemia among infected blood donors with a potential association between parasite lineage and transfusion transmissionCurrent epidemiological trends of Chagas disease in Latin America and future challengesOther forms of transmissionBloodSelective Testing of At-Risk Blood Donors for Trypanosoma cruzi and Plasmodium spp. in SwitzerlandEffects of Ultrasonic Disintegrates from Epimastigote Biomass of Trypanosoma cruzi Albarrada Strain (Mexico) on the Development of L5178Y Solid Malignant Transplanted Tumors in Male BALB/c MiceEvidence of meaningful levels of Trypanosoma cruzi in platelet concentrates from seropositive blood donorsChagas' Disease (American Trypanosomiasis): a Tropical Disease Now Emerging in the United StatesSelective testing for Trypanosoma cruzi : the first year after implementation at Canadian Blood ServicesTrypanosoma cruzi infection in North America and Spain: evidence in support of transfusion transmission (CME)Chagas disease in the immunosuppressed hostEvaluating pathogen reduction of Trypanosoma cruzi with riboflavin and ultraviolet light for whole bloodReferencesChagas Disease Has Now Gone GlobalMaladie de Chagas et transfusion sanguine : un problème parasitaire émergent dans les pays non endémiquesAcute and Congenital Chagas DiseaseTransfusion MedicineTransfusion transmitted Chagas disease: Is it really under control?Gene Network Analysis during Early Infection of Human Coronary Artery Smooth Muscle Cells by Trypanosoma cruzi and Its gp83 LigandIdentification of Novel Diagnostic Serum Biomarkers for Chagas' Disease in Asymptomatic Subjects by Mass Spectrometric ProfilingBLOOD DONORS AND BLOOD COLLECTION: Testing blood donors for Chagas disease in the Paris area, France: first results after 18 months of screeningInfection of Kissing Bugs with Trypanosoma cruzi , Tucson, Arizona, USACurrent Trends and Future Prospects for Control of Chagas DiseaseOther Forms of TransmissionCurrent epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policyNatural Chagas disease in four baboonsChagas' disease: lessons from routine donation testingThe protozoan parasitesAssessment of a travel question to identify donors with risk of Trypanosoma cruzi: operational validity and field testingPathogen inactivation of Trypanosoma cruzi in plasma and platelet concentrates using riboflavin and ultraviolet lightHuman Defensin α-1 Causes Trypanosoma cruzi Membrane Pore Formation and Induces DNA Fragmentation, Which Leads to Trypanosome DestructionEpidemiology of Chagas disease in non endemic countries: the role of international migrationThe emergence of Chagas disease in the United States and CanadaThe globalization of Chagas diseaseTransfusion-acquired Trypanosoma cruzi infectionThe Sero-Prevalence of Antibodies to Trypanosoma cruzi in Latin American Refugees and Immigrants to CanadaVirus-Safe Products: Pathogen Reduction and InactivationOther Viral, Bacterial, Parasitic and Prion-Based Infectious ComplicationsEvaluation of a new enzyme-linked immunosorbent assay for detection of Chagas antibody in US blood donorsField evaluation of four novel enzyme immunoassays for Chagas' disease in Venezuela blood banks: comparison of assays using fixed-epimastigotes, fixed-trypomastigotes or trypomastigote excreted?secreted antigens from two Trypanosoma cruzi strainsTransfusion-transmitted American and African trypanosomiasis (Chagas disease and sleeping sickness): neglected or reality?Prevalence of Antibodies to Trypanosoma cruzi among Solid Organ Donors in Southern California: A Population at RiskInduction of cardiac autoimmunity in Chagas heart disease: A case for molecular mimicryTrypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection)The Trypanosoma cruzi–host-cell interplay: location, invasion, retentionProtecting the Blood Supply From Emerging Pathogens: The Role of Pathogen InactivationDevelopment and Comparison of Enzyme Immunoassays for Diagnosis of Chagas' Disease Using Fixed Forms of Trypanosoma cruzi (Epimastigotes, Amastigotes, and Trypomastigotes) and Assessment of Antigen Stability for the Three AssaysEmerging Infectious Threats to the Blood SupplyChagas disease: current epidemiological trends after the interruption of vectorial and transfusional transmission in the Southern Cone countriesAction of Trypanosoma rangeli in infections with virulent Trypanosoma cruzi populationsRisks associated with transfusion of cellular blood components in canadaChanging epidemiology and approaches to therapy for Chagas diseaseTrypanocidal drugs for late stage, symptomatic Trypanosoma cruzi infection (Chagas disease)Expression and purification of functional, recombinant Trypanosoma cruzi complement regulatory proteinAminoquinolone WR6026 as a feasible substitute for gentian violet in Chagas' disease prophylaxis in preserved blood for transfusional purposesSome Aspects of Protozoan Infections in Immunocompromised Patients: A ReviewTrypanosoma cruzi in Los Angeles and Miami blood donors: impact of evolving donor demographics on seroprevalence and implications for transfusion transmissionLong term evaluation of etiological treatment of Chagas disease with benznidazoleInactivation of infectious pathogens in labile blood components: meeting the challengeThe Protozoan Parasites—Malaria and Chagas' DiseaseInactivation of Viruses, Bacteria, Protozoa, and Leukocytes in Labile Blood Components by Using Nucleic Acid Targeted MethodsAntibodies to Trypanosoma cruzi among blood donors in Buenos Aires, ArgentinaNew technologies for the inactivation of infectious pathogens in cellular blood components and the development of platelet substitutesStudy of the Interaction Between Trypanocide 3-Nitrobenzaldehyde Guanyl Hydrazone and Bovine Serum Albumin by Equilibrium Dialysis and NmrAmerican Trypanosomiasis (Chagas' Disease) and Blood Banking in Mexico CityRemoval of Trypanosoma cruzi by white cell-reduction filters: an electronmicroscopic studyTrypanosoma cruzi in a low- to moderate-risk blood donor population: seroprevalence and possible congenital transmissionAlien Species and Emerging Infectious Diseases: Past Lessons and Future ImplicationsInactivation of viruses, bacteria, protozoa, and leukocytes in platelet concentrates: Current research perspectivesBiological characterization and genetic diversity of Mexican isolates of Trypanosoma cruziInactivation of Viruses, Bacteria, Protozoa, and Leukocytes in Platelet ConcentratesPrevalence and epidemiological significance ofTrypanosoma cruzi infection among latin american immigrants in Berlin, GermanyA highly sensitive and specific chemiluminescent enzyme-linked immunosorbent assay for diagnosis of active Trypanosoma cruzi infectionSerological diagnosis of Chagas' disease: a potential confirmatory assay using preserved protein antigens of Trypanosoma cruziTrypanosoma cruzi strains partition into two groups based on the structure and function of the spliced leader RNA and rRNA gene promotersA simple Trypanosoma cruzi enzyme-linked immunoassay for control of human infection in nonendemic areasAMERICAN TRYPANOSOMIASIS (CHAGAS' DISEASE)Strategies for prevention of transfusion-associated Chagas' diseaseVIRUS INACTIVATION IN CELLULAR COMPONENTSChagas' heart diseasePrevalence of anti-R-13 antibodies in human Trypanosoma cruzi infectionCurrent concepts on the transmission of bacteria and parasites by blood componentsUtility of recombinant flagellar calcium-binding protein for serodiagnosis of Trypanosoma cruzi infectionAbsence of Serological Surrogate Markers for Trypanosoma-cruzi -Infected Blood DonorsDetection of antibodies to Trypanosoma cruzi among blood donors in the southwestern and western United States. I. Evaluation of the sensitivity and specificity of an enzyme immunoassay for detecting antibodies to T. cruziPrevention of transfusion-associated Chagas' disease by sterilization of Trypanosoma cruzi-infected blood with gentian violet, ascorbic acid, and lightFactors predisposing cancer patients to infectionCURRENT CONCEPTS ON TRANSMISSION OF BACTERIA AND PARASITES BY BLOOD COMPONENTSCHAGAS' DISEASEThe United States of AmericaChagas' Disease (American Trypanosomiasis)International migration and control of communicable diseasesPurification of a 74-kilodalton surface glycoprotein from heart myoblasts that inhibits binding and entry of Trypanosoma cruzi into heart cellsCHAGAS DISEASEAmerican Trypanosomiasis (Chagas' Disease) -- A Tropical Disease Now in the United StatesChallenges in Transfusion MicrobiologyChagas Disease: An Old Entity in New PlacesHazards of Bacterial Contamination of Blood ProductsTransfusion Transmitted Infection: Viral and Exotic DiseasesChagas' Disease and Blood Transfusion: A New World Problem?Chagas' diseaseAchalasia evolving from segmental aperistalsisPurification of a Trypanosoma cruzi trypomastigote 60-kilodalton surface glycoprotein that primes and activates murine lymphocytesChagas' disease in the United StatesDoes Changas' disease exist as an undiagnosed form of cardiomyopathy in the United States?PCR amplification of mini-exon genes differentiates Trypanosoma cruzi from Trypanosoma rangeliChagas' disease: Another cause of cerebral mass in the acquired immunodeficiency syndromeEvaluation of recombinant trypomastigote surface antigens of Trypanosoma cruzi in screening sera from a population in rural Northeastern Brazil endemic for chagas' diseasePerspectives on Chagas Disease in Latin America and the United StatesParasitic diseases of the heart I: Acute and chronic Chagas' diseaseAttachment of Trypanosomacruzi to host cells: A monoclonal antibody recognizes a trypomastigote stage-specific epitope on the gp 83 required for parasite attachmentComplications related to intraoperative blood component therapyNosocomial Transmission and Infection Control Aspects of Parasitic and Ectoparasitic Diseases Part II. Blood and Tissue ParasitesTransmission of Parasitic and Bacterial Infections Through Blood Transfusion within the USLatin American immigrants—Blood donation and Trypanosoma cruzi transmissionPurification of Trypanosoma cruzi surface proteins involved in adhesion to host cellsIs Trypanosoma cruzi a New Threat to Our Blood Supply?Louis V. Kirchhoff, MD, MPHInfection in Relation to Thoracic Transplantation 15 November 1989Volume 111, Issue 10Page: 851-853KeywordsBlood donorsCancer treatmentNeutropeniaOpportunistic infectionsParasitologyProtein S deficiencyResearch laboratoriesThrombosisTrypanosomaTrypanosoma cruzi ePublished: 1 December 2008 Issue Published: 15 November 1989 PDF downloadLoading ...