tbuckley/cabot-search huggingface dataset:
Purification and characterization of an abnormal factor IX (Christmas factor) molecule. Factor IX Chapel Hill.
Authors: K S Chung, D A Madar, J C Goldsmith, H S Kingdon, H R Roberts
Journal: Journal of Clinical Investigation (1978)

Human Factor IX (Christmas factor) was isolated from the plasma of a patient with mild hemophilia B. The patient's plasma contained 5% Factor IX clotting activity but 100% Factor IX antigenic activity as determined by immunological assays, which included inhibitor neutralization and a radioimmunoassay for Factor IX. This abnormal Factor IX is called Factor IX Chapel Hill (Factor IXCH). Both normal Factor IX and Factor IXCH have tyrosine as the NH2-terminal amino acid. The two proteins have a similar molecular weight, a similar amino acid analysis, the same number of gamma-carboxyglutamic acid residues (10 gamma-carboxyglutamic acid residues), and a similar carbohydrate content. Both exist as a single-chain glycoprotein in plasma. The major difference between normal Factor IX and Factor IXCH is that the latter exhibits delayed activation to Factor IXa in the presence of Factor XIa and Ca2+. Thus, Factor IXCH differs from other previously described abnormal Factor IX molecules.
Survival Prediction in Everolimus-treated Patients with Metastatic Renal Cell Carcinoma Incorporating Tumor Burden Response in the RECORD-1 Trial
Authors: Andrew Stein, Joaquim Bellmunt, Bernard Escudier, Dennis Kim, Sotirios G. Stergiopoulos, William Mietlowski, Robert J. Motzer
Journal: European Urology (2012)
Association of change in daily step count over five years with insulin sensitivity and adiposity: population based cohort study
Authors: T. Dwyer, A.-L. Ponsonby, O. C. Ukoumunne, A. Pezic, A. Venn, D. Dunstan, E. Barr, S. Blair, J. Cochrane, P. Zimmet, J. Shaw
Journal: BMJ (2011)

Genetically encoded biosensors can be used to track signaling events in living cells by measuring changes in fluorescence emitted by one or more fluorescent proteins. Here, we describe the use of genetically encoded biosensors based on Förster resonance energy transfer (FRET), combined with high-content microscopy, to image dynamic signaling events simultaneously in thousands of neurons in response to drug treatments. We first applied this approach to examine intercellular variation in signaling responses among cultured striatal neurons stimulated with multiple drugs. Using high-content FRET imaging and immunofluorescence, we identified neuronal subpopulations with unique responses to pharmacological manipulation and used nuclear morphology to identify medium spiny neurons within these heterogeneous striatal cultures. Focusing on protein kinase A (PKA) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in the cytoplasm and nucleus, we noted pronounced intercellular differences among putative medium spiny neurons, in both the magnitude and kinetics of signaling responses to drug application. Importantly, a conventional “bulk” analysis that pooled all cells in culture yielded a different rank order of drug potency than that revealed by single-cell analysis. Using a single-cell analytical approach, we dissected the relative contributions of PKA and ERK1/2 signaling in striatal neurons and unexpectedly identified a novel role for ERK1/2 in promoting nuclear activation of PKA in striatal neurons. This finding adds a new dimension of signaling crosstalk between PKA and ERK1/2 with relevance to dopamine D1 receptor signaling in striatal neurons. In conclusion, high-content single-cell imaging can complement and extend traditional population-level analyses and provides a novel vantage point from which to study cellular signaling. <h3>SIGNIFICANCE STATEMENT</h3> High-content imaging revealed substantial intercellular variation in the magnitude and pattern of intracellular signaling events driven by receptor stimulation. Since individual neurons within the same population can respond differently to a given agonist, interpreting measures of intracellular signaling derived from the averaged response of entire neuronal populations may not always reflect what happened at the single-cell level. This study uses this approach to identify a new form of cross-talk between PKA and ERK1/2 signaling in the nucleus of striatal neurons.
441 SURVIVIN-TARGETED RNA INTERFERENCE INDUCES CELL CYCLE REDISTRIBUTION AND APOPTOTIC GROWTH INHIBITION OF HEPATOMA CELLS
Authors: I.H. Song, E.Y. Kim, D.W. Kim, K.C. Shin, S.Y. Yun, S.B. Kim, J.E. Shin, H.J. Kim, S.H. Yang
Journal: Journal of Hepatology (2008)
158 MORTALITY AFTER SURGERY IN PATIENTS WITH LIVER CIRRHOSIS: COMPARISON BETWEEN CTP, MELD AND MELDNA SCORE
Authors: H.C. Cho, D.H. Sinn, H.Y. Jung, M.S. Choi, K.C. Koh, S.W. Paik, B.C. Yoo, S.W. Kim, J.H. Lee
Journal: Journal of Hepatology (2010)
Patient-Therapist Sexual Contact
Authors: Roberta J. Apfel, Bennett Simon
Journal: Psychotherapy and Psychosomatics (1985)

The problem of patient-therapist sexual contact is a substantial one, perhaps involving 5–10% of male therapists, and we suggest that the structure of psychotherapy and abundance of rescue fantasies make it inevitable. While skeptical of claims that there are any positive effects, we catalogue many negative effects: ambivalence and mistrust of subsequent therapists; patients doubting their own sense of reality; childhood trauma repeated and fixated instead of being interpreted; bondage to the offending therapist; original complaints of sexual dysfunction and problems in intimacy with men are exacerbated; burdens of guilt and shame carried by the patient; fantasy aspects of sexuality difficult to discuss in subsequent therapy, and the abrupt ending of the relationship leaving patient stranded and/or disorganized.
1091-223 The implantable defibrillator and the long QT syndrome: An overview of current use and outcome
Authors: Lia Crotti, Carla Spazzolini, Maurizio Landolina, Gaetano M De Ferrari, Raffaella Bloise, Carlo Napolitano, Gerold Monnig, Pedro Brugada, Lauri Toivonen, Stefan H Hohnloser, Silvia G Priori, Peter J Schwartz
Journal: Journal of the American College of Cardiology (2004)
Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart. Regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes.
Authors: L Belhassen, R A Kelly, T W Smith, J L Balligand
Journal: Journal of Clinical Investigation (1996)

Cardiac myocytes express the nitric oxide synthase isoform originally identified in constitutive nitric oxide synthase cells (NOS3), which mediates the attenuation by muscarinic cholinergic agonists of beta-adrenergic stimulation of L-type calcium current and contractility in these cells. However, calcium current and contractility in these cells. However, the reciprocal regulation of NOS3 activity in myocytes by agents that elevate cAMP has not been reported. In this study, we show that NOS3 and mRNA and protein levels in cardiac myocytes are reduced both in vitro after treatment with cAMP elevating drugs, and in vivo after 3 d of treatment with milrinone, a type III cAMP phosphodiesterase inhibitor. This effect on NOS3 activity by cAMP is cell type specific because treatment of cardiac microvascular endothelial cells in vitro or in vivo did not decrease NOS3 mRNA or protein in these cells. NOS3 downregulation in myocytes appeared to be at the level of transcription since there was no modification of NOS3 mRNA half-life by agents that increase intracellular cAMP. To determine the functional effects of NOS3 downregulation, we examined the contractile responsiveness of isolated electrically paced ventricular myocytes, isolated from animals that had been treated in vivo with milrinone, to the beta-adrenergic agonist isoproterenol and the muscarinic cholinergic agonist carbamylcholine. There was no difference in baseline contractile function in cells that had been pretreated with cAMP elevating agents compared to controls, but cells exposed to milrinone in vivo exhibited an accentuation in their contractile responsiveness to isoproterenol compared to controls and a loss of responsiveness to carbamylcholine. Downregulation of myocyte NOS3 by sustained elevation of cAMP may have important implications for the regulation of myocardial contractile state by the autonomic nervous system.
18F-FDG PET for Diagnosis and Response Assessment for Aggressive NK Cell Leukemia
Authors: Jeong A. Park
Journal: Clinical Nuclear Medicine (2013)

Aggressive natural killer cell leukemia (ANKL) is a rare malignant disorder of mature NK cells characterized by aggressive clinical course and poor outcome. The commonly involved sites are peripheral blood, bone marrow, liver, and spleen, but any organ can show involvement. We report a case of ANKL diagnosed and assessed the clinical response with 18F-FDG PET. Pretreatment and posttreatment FDG PET/CT showed a high correlation with pathologic diagnosis and staging as well as in the follow-up assessment of the clinical response. FDG PET could be a valuable tool enabling comprehensive staging and follow-up of ANKL.
Pregnancy and Dysplastic Nevus Syndrome-Reply
Authors: Arthur J. Sober
Journal: JAMA (1985)

In Reply.—  Dr Nichols is correct in his assertion that the effects of pregnancy on dysplastic nevi remain to be established. However, since dysplastic nevi are currently thought to be present in only 2% to 4% of the white population, the relatively reassuring data presented in the article of Foucar et al 1 would seem to be applicable to the remaining 96% to 98% of women who do not have dysplastic nevi. Anecdotally, I have followed several women with dysplastic nevi closely through pregnancy without discerning significant clinical changes in their nevi. I have been recommending close follow-up at three-month intervals for this group during pregnancy.  The relationship, if any, between pregnancy and cutaneous melanoma is not clear at this time. While I have seen several women who have developed aggressive primary melanomas during pregnancy, I have seen similar events in nonpregnant women and in men. What is needed is
Metastatic Parathyroid Carcinoma to the Liver Treated With Radiofrequency Ablation and Transcatheter Arterial Embolization
Authors: Avo Artinyan, Eduardo Guzman, Ellie Maghami, Mohammed Al-Sayed, Massimo D'Apuzzo, Lawrence Wagman, Joseph Kim
Journal: Journal of Clinical Oncology (2008)
Methylmalonic aciduria due to a new defect in adenosylcobalamin accumulation by cells
Authors: Bernard A. Cooper, David S. Rosenblatt, David Watkins
Journal: American Journal of Hematology (1990)

Abstract A child with methylmalonic aciduria due to failure to accumulate adocbl in mitochondria has a phenotype similar to cblA disease. Deficient utilization of labeled propionate by his fibroblasts is corrected by their fusion with those from cblA patients, indicating that he belongs to a different complementation class and probably is deficient in a different gene product. The defect appears not to be due to reduced affinity of enzymes for adocbl, or for ATP, and the minimal thiol required for adocbl synthesis is not different from that of extracts of normal cells.
TCT-152 Impact of Body Surface Area on Outcomes in Patients With Lower Extremity Peripheral Arterial Disease
Authors: Alix Tercius, Tonga Nfor, Naoyo Mori, Fuad Jan, Alexander Mayer, Khawaja Ammar, Anjan Gupta, Suhail Allaqaband, Tanvir Bajwa
Journal: Journal of the American College of Cardiology (2012)
New drugs for hyponatraemia
Authors: A. Amin, K. Meeran
Journal: BMJ (2010)

Evidence is lacking that they are better than cheaper standard treatment

Hyponatraemia is the most common electrolyte abnormality, especially in patients in hospital,1 and it is associated with substantial morbidity and mortality.2 The causes of hyponatraemia are often difficult to ascertain and may be multifactorial. Treatment varies according to the cause, severity of symptoms, and speed of onset. Tolvaptan, a vasopressin 2 receptor antagonist, has recently been licensed in the United Kingdom for the treatment of hyponatraemia secondary to the syndrome of inappropriate antidiuretic hormone secretion⇓.



Otsuka

Arginine vasopressin, also known as antidiuretic hormone, regulates the renal clearance of free water. Raised concentrations of arginine vasopressin cause the kidneys to retain water, and disorders of its release and regulation cause an imbalance in total body water. Vasopressin 2 receptors are found mainly in the collecting ducts of the kidneys, where they control free water reabsorption. These receptors have been targeted by non-peptide vasopressin 2 receptor antagonists, which promote the excretion of water without loss of electrolytes. These agents were originally developed for the treatment of hyponatraemia as a result of heart failure, decompensated cirrhosis, and the syndrome of inappropriate antidiuretic hormone secretion.

Tolvaptan was licensed after completion of …
NHS staff told to maintain pressure towards race equality
Authors: C. White
Journal: BMJ (2009)

The NHS must not allow current political uncertainties and the looming public spending squeeze to derail hard won progress towards race equality, delegates at a London summit for NHS leaders on the matter were warned earlier this week.

Speaking at the summit, which was organised by Race for Health and includes 21 primary care trusts, Gideon Ben-Tovim, its new chairman and chairman of Liverpool Primary Care Trust, said that “race equality and health is coming to a crucial crossroads.”

Citing among other moves the establishment of the Department of Health’s new equality and diversity council, which held its first meeting last week, and imminent equality legislation, he said that leadership was “more committed, systemic, and explicit than ever …
PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism
Authors: Roland B. Walter, Jason L. Pirga, Michelle R. Cronk, Sasha Mayer, Frederick R. Appelbaum, Deborah E. Banker
Journal: Blood (2005)
Poor training, staff cuts, and over emphasis on targets led to failures at Stafford hospital, says inquiry
Authors: H. Mooney
Journal: BMJ (2010)

The findings of an independent inquiry into Mid Staffordshire NHS Foundation Trust by Robert Francis QC found that appalling failures in patient safety and care were caused by inadequate training of staff, staff cut backs, and an over emphasis on government targets by the trust’s senior management team.

The inquiry was launched into events at Stafford hospital after a damning report last March from the Healthcare Commission showed a catalogue of failings at the trust where at least 400 more people died than would have been expected in a three year period from 2005 to 2008. The report explains how patients were neglected and left in pain as the trust focused on its finances and on hitting government targets in a bid to attain foundation status.

Commenting on the report’s findings, Mr Francis said that …
Reduced hearing, ownership, and use of hearing aids in elderly people in the UK–the MRC Trial of the Assessment and Management of Older People in the Community: a cross-sectional survey
Authors: Liam Smeeth, Astrid E Fletcher, Edmond Siu-Woon Ng, Sue Stirling, Maria Nunes, Elizabeth Breeze, Christopher J Bulpitt, Dee Jones, Alistair Tulloch
Journal: The Lancet (2002)
THE RELATION OF DISEASE OF THE NASAL ACCESSORY SINUSES TO DISEASE OF THE EYES.
Authors: FRANK E. BRAWLEY
Journal: JAMA (1907)

That the nose and its pathology have a direct influence on the health and function of the eyes has long been admitted, and the more obvious and striking forms of interdependent diseases have for a long period been recognized and treated. It is unnecessary to mention the ordinary examples of associated disease. I wish to call your attention to a practically unrecognized condition. The symptoms of this condition are purely ocular. The patient never has a reason to suspect a nasal origin, and, as use of the eyes almost invariably increases the headache of this condition, he consults an oculist for relief. Another reason for believing that the eyes are at fault is that correct glasses relieve for a time all or the greater part of the symptoms. This may be explained by the lessened congestion of the ciliary body resulting from a relief of eyestrain, however small in amount.
Casebook of Psychiatric Emergencies: The 'On Call' Dilemma
Authors: Carl C. Bell
Journal: JAMA (1984)

No physician should work in an emergency setting until he has read this book. It contains more than 60 brief emergency room case histories that cover the full range of psychiatric problems that any emergency room physician will likely ever face. The cases are realistically presented and stimulate the formulation of theories, attitudes, and practices necessary for an average emergency room physician to treat psychiatric cases in a practical and efficient manner. The introductory chapter firmly grounds the reader in down-to-earth knowledge and skills essential for handling psychiatric emergencies. The next chapter discusses the "social buffer" function of emergency psychiatric services and gives instructive clinical cases on confidentiality, homeless patients, refill requests for prescriptions, derelicts, follow-up outpatient treatment reinforcement, physical abuse, problems with emergency services sabotaging consistent outpatient care, and patients who feign psychiatric illness. Chapter 3 presents issues of suicide as they relate to adolescence, telephone calls, attempts, support
Principles and Practice of Clinical Cardiology
Authors: Arthur J. Moss
Journal: JAMA (1984)

This cardiologic text by a master clinical cardiologist provides a broad overview of a complex field, which is undergoing rapid technological changes. Like Drs White, Levine, and Friedberg of the previous generation, Dr Selzer has transcribed his thinking process into words and has presented a personal approach to cardiologic problem solving. The book avoids the pitfalls of many multiauthored texts, and the reader does not lose sight of the forest for the trees. The reader, whether student, house officer, internist, or cardiologist, is provided with a wealth of practical clinical information with emphasis on thinking, reasoning, and good judgment.  The book is divided into two parts. The first half focuses on general cardiology and deals with diagnosis, therapy, and disturbances of mechanical and electrical cardiac performance. In the second part, specific diseases of the heart and circulation are highlighted with particular emphasis on the natural history and clinical course of
Significance of regional wall thickening abnormalities relative to transmural myocardial perfusion in anesthetized dogs.
Authors: K P Gallagher, T Kumada, J A Koziol, M D McKown, W S Kemper, J Ross
Journal: Circulation (1980)

In 15 open-chest, anesthetized dogs, regional systolic wall thickening (% delta WT) was measured with sonomicrometry and regional blood flow was determined with tracer microspheres (7-10 micron) before and after various degrees of coronary artery narrowing were created with a hydraulic occluder. The stenoses were categorized into four groups by the effect on % delta WT, and the corresponding myocardial blood flow (MBF) was determined in four layers across the ventricular wall (layer 1: subendocardium; layer 4: subepicardium). In group 1, % delta WT decreased 44 +/- 10% and only layer 1 MBF was significantly reduced (-28%); in group 2, % delta WT decreased 77 +/- 8% and MBF was reduced in both layers 1 and 2 (-52% and -36%, respectively); in group 3, % delta WT decreased 104 +/- 3% and MBF was reduced in the three inner layers (layer 1: -65%; layer 2: -58%; layer 3: -34%); in group 4, % delta WT decreased 145 +/- 9% (systolic wall thinning) and transmural reduction of MBF was found (layer 1: -74%; layer 2: -68%; layer 3: -55%; layer 4: -29%). We conclude that (1) up to 75% reduction in systolic wall thickening may occur when perfusion to only the inner one-half of the myocardium is decreased; (2) akinetic wall motion may be observed when perfusion remains normal in the subepicardial one-fourth of the wall; and (3) dyskinesia (wall thinning) occurs when blood flow is reduced transmurally.
THE ROENTGEN RADIATION OF PAPILLOMA VIRUS (SHOPE)
Authors: J. T. Syverton, G. P. Berry, S. L. Warren
Journal: The Journal of Experimental Medicine (1941)

Cell-free suspensions of papilloma virus (Shope) required for their inactivation in vitro amounts of Roentgen irradiation that are much greater than those needed to inactivate other infectious agents previously described. These amounts, millions of r units, are several thousand times greater than those required to eradicate permanently papillomas induced by the virus in domestic rabbits. Large doses of Roentgen radiation reduce the titer of papilloma virus, lengthen the period of time between inoculation and the appearance of papillomas, and decrease the size attained by the papillomas.
Obituary Listing
Authors: Jr Ray W. Gifford
Journal: JAMA (1998)

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