tbuckley/cabot-search huggingface dataset:
Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea–hypopnea syndrome
Authors: Shigehiko Imagawa, Yuji Yamaguchi, Masato Higuchi, Tomohiro Neichi, Yuichi Hasegawa, Harumi Y. Mukai, Norio Suzuki, Masayuki Yamamoto, Toshiro Nagasawa
Journal: Blood (2001)
Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin
Authors: Jeffrey S. Dubins, Manuel Sanchez-Alavez, Victor Zhukov, Alejandro Sanchez-Gonzalez, Gianluca Moroncini, Santos Carvajal-Gonzalez, John R. Hadcock, Tamas Bartfai, Bruno Conti
Journal: Metabolism (2012)
Excretory Urography, Cystography, and Cystoscopy in the Evaluation of Women with Urinary-Tract Infection
Authors: Jackson E. Fowler, E. Thomas Pulaski
Journal: New England Journal of Medicine (1981)

IT has been estimated that 10 to 20 per cent of women will have urinary-tract infection at some time during their lives1 and that about 99 per cent of those with recurrent infections will have urinary-tract reinfections, as opposed to persistent urinary-tract infections.2 The value of radiographic and endoscopic investigations of the urinary system in women with such reinfections, however, has not been clearly defined. We report a prospective study of findings with excretory urography, cystography, and cystoscopy in women with symptomatic urinary-tract infection and an analysis of the effects of the findings on treatment. The great majority of these . . .
Ozone exposure assessment in a southern California community.
Authors: L J Liu, R Delfino, P Koutrakis
Journal: Environmental Health Perspectives (1997)

An ozone exposure assessment study was conducted in a Southern California community. The Harvard ozone passive sampler was used to monitor cohorts of 22 and 18 subjects for 8 weeks during the spring and fall of 1994, respectively. Ozone exposure variables included 12-hr personal O3 measurements, stationary outdoor O3 measurements from a continuous UV photometer and from 12-hr Harvard active monitors, and time-activity information. Results showed that personal O3 exposure levels averaged one-fourth of outdoor stationary O3 levels, attributable to high percentages of time spent indoors. Personal O3 levels were not predicted well by outdoor measurements. A random-effect general linear model analysis indicated that variance in personal exposure measurements was largely accounted for by random error (59-82%), followed by inter-subject (9-18%) and between-day (9-23%) random effects. The microenvironmental model performs differently by season, with the regression model for spring cohorts exhibiting two times the R2 of the fall cohorts (R2 = 0.21 vs. 0.09). When distance from the stationary monitoring site, elevation, and traffic are taken into account in the microenvironmental models, the adjusted R2 increased almost twofold for the fall personal exposure data. The low predictive power is due primarily to the apparent spatial variation of outdoor O3 and errors in O3 measurements and in time-activity records (particularly in recording the use of air conditioning). This study highlights the magnitude of O3 exposure misclassification in epidemiological settings and proposes an approach to reduce exposure uncertainties in assessing air pollution health effects.
Pathology of chronic mountain sickness
Authors: J. Arias-Stella, H. Kruger, S. Recavarren
Journal: Thorax (1973)

Radiogenomics promises to identify tumour imaging features indicative of genomic or proteomic aberrations that can be therapeutically targeted allowing precision personalised therapy. An accurate radiological–pathological correlation is critical to the process of radiogenomic characterisation of tumours. An accurate correlation, however, is difficult to achieve with current pathological sectioning techniques which result in sectioning in non-standard planes. The purpose of this work is to present a technique to standardise hepatic sectioning to facilitateradiological–pathological correlation. We describe a process in which three-dimensional (3D)-printed specimen boxes based on preoperative cross-sectional imaging (CT and MRI) can be used to facilitate pathological sectioning in standard planes immediately on hepatic resection enabling improved tumour mapping. We have applied this process in 13 patients undergoing hepatectomy and have observed close correlation between imaging and gross pathology in patients with both unifocal and multifocal tumours.
Implications of smoking status on the response to therapeutic angiogenesis in peripheral artery disease: findings from the therapeutic angiogenesis with FGF-2 for intermittent claudication (TRAFFIC) trial
Authors: Jorge F. Saucedo, Mohammed M. Moursi, R.D. Anderson, Farrell O. Mendelsohn, James B. Hermiller, Robert Federici, James Zidar, Adam B. Greenbaum, Thomas Moon, M.J. Whitehouse, Brian H. Annex, Robert J. Lederman
Journal: Journal of the American College of Cardiology (2002)
F-18-FDG Uptake in Tuberculosis
Authors: SIEMA M. B. BAKHEET, JOHN POWE, ADNAN EZZAT, ASSEM ROSTOM
Journal: Clinical Nuclear Medicine (1998)

Two patients are described who showed abnormal fluorine-18 fluorodeoxyglucose (F-18 FDG) uptake that was due to benign disease, specifically tuberculous lymphadenitis and pneumonitis. The first patient had ulceration and oozing of the left nipple that was related to Paget's disease. An F-18 FDG PET, whole-body scan, which was performed for staging, showed no breast uptake. However, there was intense multifocal uptake in mediastinal, supraclavicular, and para-aortic areas that was confirmed radiologically to represent widespread lymphadenopathy. Pathologic examination of a mediastinal lymph node showed active tuberculosis. The second patient showed intense focal F-18 FDG uptake in mediastinal and supraclavicular areas and para-aortic lymphadenopathy due to non-Hodgkin's lymphoma. In addition, there was abnormal F-18 FDG lung uptake that revealed the presence of acid-fast bacilli on bronchial lavage. Intense focal F-18 FDG uptake in widespread lymphadenopathy or in the lung could be caused by infectious diseases such as tuberculosis. This possibility should be considered when whole-body scans of patients with cancer are interpreted, especially in those with a high incidence of infectious disease.
RECTAL GONORRHEA IN WOMEN
Authors: CLEMENT L. MARTIN
Journal: JAMA (1935)

Gonococcic infection of the rectum decidedly is not an uncommon complication in women who harbor this infection in the cervix or the urethra. Symptoms often are absent; nearly always they are mild. As a consequence the disorder rarely is diagnosed. Years ago Jullien<sup>1</sup>stated that rectal gonorrhea "is a disease one sees only if one looks for it." This statement is still pertinent. The lesion commonly results from genital gonorrhea. Although not uncommon, it is not very frequently encountered in the ordinary run of examinations in women in a proctologic practice. The disease is rather uncommon in males and rare as a primary ailment in women. Of 220 men having gonorrhea in the Chicago House of Correction Hospital, a group in which the incidence would be expected to be relatively high, De Bere<sup>2</sup>found rectal gonorrhea in a little over 2 per cent of the cases. Although many
Contemporary Threats to Adolescent Health in the United States
Authors: Robert Blum
Journal: JAMA (1987)

Over the past 30 years, adolescents have been the only population in the United States who have not experienced improvement in their health status. Violence has replaced communicable diseases as the primary cause of juvenile mortality and, currently, over 77% of adolescent deaths are caused by accidents, suicide, and homicide. Increasingly, poverty, life-style, and risk-taking behaviors are influencing the morbidities of youth, with associated sequelae of trauma, adolescent pregnancy, substance abuse, physical/sexual abuse, and most other major health problems of adolescents. Clinicians seem to be interested in addressing the shifting nature of adolescent morbidity, yet are insufficiently trained to be effective. The physician must go beyond traditional clinical medicine and address the social, environmental, and behavioral factors that underlie current morbidity.
Effects of the nitric oxide synthase inhibitors NG-nitrol-L-arginine methyl ester and aminoethyl-isothiourea on the liver microcirculation in rat endotoxemia
Authors: Carlos O. Corso, Yngvar Gundersen, Martina Dörger, Per Lilleaasen, Ansgar O. Aasen, Konrad Messmer
Journal: Journal of Hepatology (1998)
Mineral content of the forearms of babies born to Asian and white mothers.
Authors: P Congdon, A Horsman, P A Kirby, J Dibble, T Bashir
Journal: BMJ (1983)

Vitamin D deficiency is common in pregnant Asian women. The effect of maternal vitamin D deficiency on fetal skeletal mineralisation was assessed by measuring the bone mineral content of babies born to 45 Asian women, 19 Asian women who had received 1000 units of vitamin D during the last trimester, and 12 white women. The mean cord blood concentrations of 25-hydroxy vitamin D in the three groups were 5.9 +/- SE 0.9 nmol/l (2.4 +/- SE 0.4 ng/ml), 15.2 +/- 3.2 nmol/l (6.1 +/- 1.3 ng/ml), and 33.4 +/- 3.6 nmol/l (13.4 ng/ml), respectively. Despite this wide variation in values there was no significant difference in the bone mineral content (as assessed by photon absorptiometry) of the forearms of babies born to these women. This suggests that mineralization of the fetal skeleton is not impaired in maternal vitamin D deficiency. Craniotabes (skull softening) was present in seven of the 64 Asian babies. The bone mineral content in these babies was not significantly different from that of babies without this sign, and craniotabes should not therefore be taken as an indication of a generalized impairment in skeletal mineralization.
Increased cardiovascular risk and diabetes in Indians.
Authors: N. C. Henningsen
Journal: BMJ (1988)

rarely fatal and currently not routinely looked for: in future this and other anomalies may be part of general screening and will be relevant to decisions about termination of pregnancy.At present most laboratories can cope with the demand by mothers of 37 and over for antenatal diagnosis on grounds of their age, although prob- ably only half those who might do so actually request the investigation.'This may change with wider availability ofchorionic villus sampling since mothers who would not contemplate a termination at 19-20 weeks may accept one at 12 weeks.For correct counselling we need more knowledge of regional and ethnic variation in the incidence of chromosome anomalies.We also should know the risk of amniocentesis in our own units.It would be well if the indications for amniocentesis on grounds of maternal age were clarified to simplify the reappraisal required by the advent of chorionic villus sampling.Since this is likely to increase the number of requests for antenatal diagnosis it has implications for the overall costs of antenatal diagnosis as well as for the correct advice we should give.
Notes on a Case of Suicidal Cut-Throat
Authors: H. Galt
Journal: BMJ (1898)

given, the previous rise of temperature not having reached normal urtil II A.M.On March 12th mj was injected.The temperature rose to 0oi.60 F. in twelve hours.OIi this occasion the inijection was imiade in the clhest wall.On March x3th an injection of mij was again made in the chest wall.The reaction was less, temperature beinig higlhest at 2 P.M. (ioiO F.).On the fol- lowing day no injection was given.On March I5th an injection of mj was given.The temperature rose dur- ing reaction to TOOO F. On March x6th mj was injected, and the temperature rose to IoO.20 F. The general condition was good, the ulcerative processes more active, and the umours certainly diminishing.On March i7th, i8th, itth, and 20tll, similar injections we-e made.The temperature waq hliglhest penerally about ten hours afterwar s, but did not reach above iOG0 F. On March 20tli a large piece of the slough was removed from the tumour in the occiput, exposing part of the occipital bone to the left, whichl was rouglh anid bare.No injection was giveni oni March 2ist, but on March 22nd mj was in- jeceed.The temperature r ose to i0o.20 F. March 23rd.Injection of il minimi, temperature Io.20 F.
The stability and blanching efficacy of betamethasone-17-valerate in emulsifying ointment
Authors: K.S. RYATT, J.W. FEATHER, A. MEHTA, J.B. DAWSON, J.A. COTTERILL, R. SWALLOW
Journal: British Journal of Dermatology (1982)

The bio-availability of betamethasone-17-valerate (Betnovate ointment) in emulsifying ointment (1 in 4 dilution) was investigated in ten subjects using a single-application vasoconstrictor assay; the blanching induced was measured using a skin reflectance spectrophotometer. The vasoconstrictor activity of the diluted preparations decreased with age. There was no significant difference between the vasoconstrictor activity of freshly made Betnovate 1 in 4 in emulsifying ointment and undiluted Betnovate ointment, and between 3-4 week old diluted Betnovate and emulsifying ointment base. Blanching induced by freshly prepared 4, 8 and 16-fold dilutions was not significantly different but a large reduction in blanching occurred on diluting 32-fold with emulsifying ointment. The degradation of betamethasone -17-valerate in emulsifying ointment was quantified by high performance liquid chromatography. More than 60% of the betamethasone -17-valerate underwent degradation within 6 h. There was a simultaneous increase in the concentration of betamethasone-21-valerate which peaked within 2 days and was followed by a slow degradation (half-life 8 days) to betamethasone free alcohol.
Poor hematopoietic stem cell mobilizers: A single institution study of incidence and risk factors in patients with recurrent or relapsed lymphoma
Authors: Chitra Hosing, Rima M. Saliba, Sheena Ahlawat, Martin Körbling, Partow Kebriaei, Amin Alousi, Marcos De Lima, Julia‐Grace Okoroji, John McMannis, Muzaffar Qazilbash, Paolo Anderlini, Sergio Giralt, Richard E. Champlin, Issa Khouri, Uday Popat
Journal: American Journal of Hematology (2009)

Abstract The purpose of this retrospective study was to determine the incidence and predictive factors if any, of mobilization failure in lymphoma patients referred for autologous stem cell transplantation. A total of 588 lymphoma patients were referred for transplant consultation from January 2003 to December 2004. Predictors of mobilization failure were evaluated using logistic regression analysis including diagnosis, mobilization regimen, age, sex, type and number of prior chemotherapies, bone marrow cellularity, platelet count, white count, prior bone marrow involvement with malignancy, and prior radiation therapy. Two hundred and six patients were eligible for transplantation and underwent stem cell mobilization. Twenty‐nine (14%) patients failed to mobilize adequate stem cells after the first attempt. For the entire group age (≥60 versus &lt;60 years), diagnosis (Hodgkin's versus non‐Hodgkin's lymphoma), use of cytokines alone, platelet count &lt;150 × 10 9 /L, and bone marrow cellularity &lt;30% were significant predictors for mobilization failure on univariate analysis. In view of small number of patients multivariate analysis was not possible. However, a low platelet count (150 × 10 9 /L) was the only significant predictor when the analysis was restricted to non‐Hodgkin's lymphoma patients who were mobilized with chemotherapy. Mobilization failure rates are higher in patients with non‐Hodgkin's lymphoma compared with those with Hodgkin's lymphoma. In the subset of patients who undergo chemomobilization for non‐Hodgkin's lymphoma platelet count at the time of mobilization is a predictor of mobilization failure. Am. J. Hematol. 2009. © 2009 Wiley‐Liss, Inc.
A CASE OF VICARIOUS MENSTRUATION FROM THE LOWER LIDS.
Authors: J. HERBERT CLAIBORNE
Journal: JAMA (1902)

A young Jewish girl of 16 presented herself at the Vanderbilt Clinic on account of hemorrhagic spots under each eye. She was pale, flabby and badly nourished. In other respects she was well. She had menstruated for the first time at 13 years of age. Since the establishment of her menses she noticed every month, two or three days before her period, that a red spot would appear under each eye. The skin would become red, the blood would rise to the surface and finally ooze through and form a clot, which dried, resulting in a crust. This lasted during her period and disappeared gradually, so that in two or three days afterward the skin would be normal again. She also said the spots would occasionally appear two or three days after her menses and would disappear as usual. There was a hypermetropia of a mild degree with normal vision.
Dr. Wangensteen's Contribution
Authors: Leonard W. Larson
Journal: JAMA (1961)

THE HONOR ROLL of doctors in medical science and research, who have received the Passano Foundation Award since 1945, represents 16 outstanding careers which have been of immeasurable value to humanity. As further evidence of the distinction of their developments and discoveries, 5 winners also have received the Nobel Prize. Each new name added to this honor roll gives recognition and appreciation to another of those individuals who can, through his own ability, spirit, and vision, pass on to others the knowledge and inspiration needed to help solve our present-day problems, and hasten the promise of tomorrow. Such a man is Dr. Owen H. Wangensteen, professor and chairman of the Department of Surgery at the University of Minnesota School of Medicine. I consider it a privilege to add his name to the honor roll as the 17th recipient of the Passano Award for his many contributions to surgical techniques and
Abstract 4963: The dynamic change of CD47 expression promotes tumor burden, metastases and resistance of breast cancer cells to radiotherapy.
Authors: Cheikh Menaa, Ming Fan, Hsien-Chen Lu, Aris Alexandrou, Shuaib Juma, Julian Perks, Jian Jian Li
Journal: Cancer Research (2013)

Abstract Immune tolerance towards malignant cells is responsible for tumor progression and metastases. Despite their immunogenicity, cancer cells developed sophisticated mechanisms by which they are able to neutralize and/or evade the immune-surveillance. Recently, the overexpression of CD47 has been suggested to participate in the immune escape mechanism in several malignant diseases. However, mechanisms involved in CD47 expression, especially in response to anticancer agents are not yet known. In this study, we found that CD47 is overexpressed in breast cancer cells (MCF7, MDA-231, 4T1 cells) compared to non-transformed breast epithelial cells (MCF10A) and this expression is further enhanced in response to radiation (5Gy). The expression of CD47 was found to be regulated by NF-κB through a specific responsive element in the CD47 promoter as assessed by gene deletion and ChiP assays. Furthermore, using syngeneic orthotopic 4T1 mouse model, we found that CD47 is critical for both tumor burden and metastases, since anti-CD47 (100 μg/day/mice) was able to reduce tumor growth when the antibody was injected during 4T1 inoculation (day 0) or 15th after tumor growth. Consequently, tumor size and lesions were reduced and mouse survival was increased in the presence of anti-CD47 and this effect was further enhanced with radiation (4 Gy/day for 5 days). Taken together, these data suggest that CD47 expression is a marker for tumor aggressiveness and resistance to anti-cancer agents and therefore could be a potential target to treat metastatic and recurrent tumors. Citation Format: Cheikh Menaa, Ming Fan, Hsien-Chen Lu, Aris Alexandrou, Shuaib Juma, Julian Perks, Jian Jian Li. The dynamic change of CD47 expression promotes tumor burden, metastases and resistance of breast cancer cells to radiotherapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4963. doi:10.1158/1538-7445.AM2013-4963
Management of breast cancer
Authors: E Roberts, L Branston
Journal: BMJ (1994)

reduce the risk of myocardial infarction "could easily be as little as 3%"?Finally, Ramsay and colleagues were surprised that in our study the control diet induced an increase in "baseline" cholesterol values.The habitual diet of people living in southern Italy is a typical example of the "Mediterranean diet," which is generally considered to be a model hypocholesterolaemic diet.Moreover, patients referred to our lipid clinic are often already taking a therapeutic diet and their cholesterol concentrations cannot be considered to be true baseline values.A standard procedure of good medical research is to start intervention studies with a run in period, in which any treatment is stopped.This is what we did.Moreover, as consumption of saturated fat in our control diet was "only" 14% we predict that if our test diets were used in any northern European country or in the United States (where habitual consumption of saturated fat is usually higher) their efficacy would be even more pronounced.
I-123 Uptake by Mediastinal Goiter After Recombinant Human Thyroid-Stimulating Hormone Administration
Authors: DWIGHT M. ACHONG, LUIS E. TENORIO
Journal: Clinical Nuclear Medicine (2001)

Radioiodine scintigraphy is useful to confirm the presence of mediastinal thyroid tissue. However, the degree of iodine avidity of mediastinal goiters varies. Recombinant human thyroid-stimulating hormone given to stimulate iodine uptake by thyroid remnants and thyroid cancer metastases can now replace thyroid hormone withdrawal scanning of selected patients who have well-differentiated thyroid carcinoma. A case of mediastinal goiter visualized with I-123 after the administration of recombinant human thyroid-stimulating hormone is reported.
FDA is criticised for hinting it may loosen conflict of interest rules
Authors: J. Lenzer
Journal: BMJ (2011)

The US Food and Drug Administration has come under fire for suggesting that it may loosen conflict of interest rules for its advisers, because of a shortage of experts without ties to the drug and medical devices industry.

The FDA’s commissioner, Margaret Hamburg, said that strict rules on conflict of interest implemented in 2008, which limit the proportion of advisory panellists with industry ties to 13%, may be slowing down approvals of products and hindering innovation. 

Dr Hamburg told journalists at a meeting held by the non-profit watchdog Public Citizen in Washington, DC, on 25 July that the agency had to be sure it had “subject-matter experts” “for our important decision making,” reported the online news service Bloomberg News (http://bloom.bg/r2QbrF …
Ibrutinib-naïve chronic lymphocytic leukemia lacks Bruton tyrosine kinase mutations associated with treatment resistance
Authors: Rosella Famà, Riccardo Bomben, Silvia Rasi, Michele Dal Bo, Carmela Ciardullo, Sara Monti, Francesca Rossi, Tiziana D’Agaro, Antonella Zucchetto, Valter Gattei, Gianluca Gaidano, Davide Rossi
Journal: Blood (2014)
Factors Influencing Return to Work
Authors: M. F. Stranc
Journal: BMJ (1971)

the fact that they are hospital-based in decid- ing which arrangement is the better.But I am certain of one thing: that there is need for experiment and that in this most important work policy based purely on depart- mental decree is not good enough.If, in the broadest sense, we are to get value for money this airing of the resettlement of the disabled should be followed by a planned comparative study.-I am, etc.,
TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function
Authors: Anne Krug, Anthony R French, Winfried Barchet, Jens A.A Fischer, Andrzej Dzionek, Jeanette T Pingel, Michael M Orihuela, Shizuo Akira, Wayne M Yokoyama, Marco Colonna
Journal: Immunity (2004)