tbuckley/cabot-search huggingface dataset:
FURTHER STUDIES OF THE STIMULATION OF DNA SYNTHESIS IN CULTURES OF SPLEEN CELL SUSPENSIONS BY HOMOLOGOUS CELLS IN INBRED STRAINS OF MICE AND RATS
Authors: Richard W. Dutton
Journal: The Journal of Experimental Medicine (1965)

The early proliferative response previously demonstrated in rabbits has now been shown to follow the mixing of spleen cell suspensions from 2 inbred strains of mice or rats. The size of the response is comparable to that seen in cells from hyperimmune animals exposed to antigen in vitro. Autoradiographs of cells from stimulated cultures showed 1 to 4 per cent of the total population had incorporated thymidine. Modifications in the conditions necessary for the culture of mice and rat spleen cell suspensions and the measurement of thymidine incorporation are described. No responses were observed in isologous mixes. The responses obtained on mixing individual pairs of spleens from different strains showed relatively little variation. Responses were obtained in all of the 21 possible combinations between 7 inbred strains of mice. Responses were obtained when parental cells were mixed with their F1 hybrids. Analysis of these responses showed that, in every case, parental-F1 hybrid responses were less intense than those between the 2 parents. It was shown that there was no inherent defect in the ability of the hybrid cells to respond when mixed with an unrelated strain. The results suggested that the hybrid cells made no response to the parent cells although this was not conclusively established. This has been taken as circumstantial evidence that the response is immunological in nature. The significance of the vigor of the response and the large fraction of the immunologically competent cells that take part is discussed.
53 PERICENTRAL DOWNREGULATION OF BSEP AND MRP2 FOLLOWING EXPERIMENTAL ISCHEMIA AND REPERFUSION IS RESTORED BY HBG200-MEDIATED PREINDUCTION OF HEME OXYGENASE-1
Authors: M.G. Donner, S.A. Topp, A. Krienen, P. Cebula, A. Macher, T. Gehrmann, B.H. Pannen, W.T. Knoefel, D. Häussinger
Journal: Journal of Hepatology (2011)
First wave of foundation hospitals unveiled
Authors: A. Gulland
Journal: BMJ (2003)

The government last week named of the 29 hospitals in England that will make up the first wave of applicants for the controversial “foundation” hospital status.

The trusts will have freedom from Whitehall control and will be able to set their own pay rates, as long as doing so “does not undermine the ability of other providers in the local health economy to meet their NHS obligations.”

The plans have met widespread opposition from NHS staff and MPs alike, with 60 Labour MPs voting against the government on the plans last week.

The applications for foundation trust status must be submitted by the autumn, and the successful hospitals (subject to parliament passing the Health and Social Care Bill) will be granted trust status in April 2004.

The trusts …
Changes in Youth Cigarette Use and Intentions Following Implementation of a Tobacco Control Program
Authors: Ursula E. Bauer, Tammie M. Johnson, Richard S. Hopkins, Robert G. Brooks
Journal: JAMA (2000)

ContextMany states are developing tobacco use prevention and reduction programs, and current data on tobacco use behaviors and how these change over time in response to program activities are needed for program design, implementation, and evaluation.ObjectivesTo assess changes in youth cigarette use and intentions following implementation of the Florida Pilot Program on Tobacco Control.Design, Setting, and ParticipantsSelf-administered survey conducted prior to program implementation (1998), and 1 and 2 years (1999, 2000) later among a sample of Florida public middle school and high school students who were classified as never users, experimenters, current users, and former users of cigarettes based on survey responses.Main Outcome MeasuresChanges in cigarette use status, intentions, and behaviors among students over a 2-year period.ResultsSurveys were completed by 22,540, 20,978, and 23,745 students attending 255, 242, and 243 Florida public middle and high schools in 1998, 1999 and 2000, respectively. Response rates for the 3 survey years ranged from 80% to 82% and 72% to 82% for the middle school and high school surveys, respectively. After 2 years, current cigarette use dropped from 18.5% to 11.1% (P<.001) among middle school students and from 27.4% to 22.6% (P = .01) among high school students. Prevalence of never use increased from 56.4% to 69.3% (P<.001) and from 31.9% to 43.1% (P = .001) among middle school and high school students, respectively. Prevalence of experimenting decreased among middle school and high school students from 21.4% to 16.2% (P<.001) and from 32.8% to 28.2% (P<.001), respectively. Among never users, the percentage of committed nonsmokers increased from 67.4% to 76.9% (P<.001) and from 73.7% to 79.3% (P<.001) among middle school and high school students, respectively. Among experimenters, the percentage of students who said they will not smoke again increased from 30.4% to 42.0% (P<.001) in middle school and from 44.4% to 51.0% (P<.001) in high school.ConclusionsProgress toward reduction of youth tobacco use was observed in each of the 2 years of Florida's Pilot Program on Tobacco Control. Our results suggest that a comprehensive statewide program can be effective in preventing and reducing youth tobacco use.
Care of the dying patient: art or science?
Authors: K. E. Sleeman
Journal: BMJ (2013)

There is an art to end of life care. But however well it is applied in the sensitive navigation of discussions with dying patients and their loved ones, it does not preclude the need for a scientific evidence base to guide care. The development of a robust evidence base requires investment in research, and, as Ellershaw and Lakhani point out,1 end of life care has long been of low priority for research …
Letter: Imported diseases.
Authors: R N Sutton
Journal: BMJ (1975)

of us spotted that he had fainted; we all mistook the faint for the onset of smooth anaesthesia, and but for a warning cried out by the technician who was following the blood pressure on the recording apparatus the patient might well have died.In the boy's case outlined above, Dr. Tomlin (2 November, p. 288) somewhat surprisingly attributes the death to pul- monary oedema.I have pointed out3 that in cases of sudden collapse and death in the dental chair when fainting was the only rational explanation pulmonary oedema seems to be a constant necropsy finding.Indeed, Dr. Tomlin himself has reported this finding.6The case was that of a woman aged 22 sitting up in the dental chair who lost consciousness and collapsed during the injection within the mouth of 1-5 ml of a standard local analgesic solution.She died and "the post-mortem revealed acute pul- monary oedean."Discussing the cause of this death, Dr. Tomlin makes no mention of the pulmonary oedema.He attributes the death either to acute sensitivity to the analgesic agent or to "a severe dysrhythmina or a 'faint'."-Iam, etc.,
Chloroma in Acute Myelogenous Leukemia
Authors: C Sauter, E Jacky
Journal: New England Journal of Medicine (1998)

Figure 1. Panel A shows a leukemic infiltrate in the skin of a 62-year-old patient with acute myelogenous leukemia (subtype M2 according to the French–American–British system of classification). Chloromas usually present as reddish-blue, not green, thickenings in the skin, but pressing the blood out of the nodule (Panel B) unmasks a green color for a few seconds (Panel C). The green color is attributed to the presence of myeloperoxidase. This color is rarely seen because the green pigment fades readily on exposure to the air and the red color of the blood masks the green pigment. Chloros is an ancient . . .
Absence of Low-Frequency Variability of Sympathetic Nerve Activity in Severe Heart Failure
Authors: Philippe van de Borne, Nicola Montano, Massimo Pagani, Ron Oren, Virend K. Somers
Journal: Circulation (1997)

In normal humans, variability of blood pressure, RR interval, and sympathetic activity occurs predominantly at a low frequency (LF; 0.04 to 0.14 Hz) and a high frequency (HF; +/-0.25 Hz). In conditions that increase sympathetic activation in normal humans, the LF component is increased relative to the HF component. Patients with heart failure have high levels of sympathetic activity. We tested the hypothesis that the LF component of sympathetic nerve activity variability is increased in heart failure.We performed spectral analysis of simultaneous recordings of resting muscle sympathetic nerve activity (MSNA) and RR interval in 21 patients with chronic heart failure and 12 age-matched control subjects. MSNA was higher in patients with heart failure (62 +/- 4 bursts per minute) than in the normal subjects (39 +/- 4 bursts per minute; P < .01). LF components of RR interval and MSNA variability were lower in the heart failure patients versus the control subjects (P < .01). HF variability of RR interval and MSNA was preserved, at least in part, in heart failure. There was close coherence between variability patterns of RR interval and MSNA. Furthermore, in 14 heart failure patients who had no LF variability in MSNA compared with 7 heart failure patients who did manifest LF variability in MSNA, RR interval was shorter, the variance of RR interval was lower, MSNA was higher, respiratory rate was faster, and left ventricular ejection fraction was lower (all P < .05). At a median follow-up of 12 months, 4 heart failure patients had died, all of whom had had absent LF oscillations in MSNA and RR interval.The LF variability of sympathetic nerve activity is absent in patients with severe heart failure. This disturbed pattern of variability is closely coherent with the abnormal variability of RR interval. These disturbances of rhythmic oscillations of autonomic outflow, evident in both RR interval and MSNA, suggest a central autonomic regulatory impairment in heart failure and may have important prognostic implications.
The McBurney Incision in Appendicitis with Abscess.
Authors: Robert T. Morris
Journal: JAMA (1906)

sup¬ ply-the NeAv York Department of Health, and the Memorial Institute for Infectious Diseases.That there may be no further misunderstanding among physicians as to what I said in the Annual Report of the De¬ partment of Health on the subject of antitoxin, from Avhich nevvspapers have quoted, and in some instances conveyed the wrong meaning, I Avish you Avould publish the article entire, as this is all I have said on the subject at any time or place.
B and T cells are not required for the viable motheaten phenotype.
Authors: C C Yu, H W Tsui, B Y Ngan, M J Shulman, G E Wu, F W Tsui
Journal: The Journal of Experimental Medicine (1996)

Hematopoietic cell phosphatase (HCP), encoded by the hcph gene, (also called PTP1C, SHP, SH-PTP1, and PTPN6) is deficient in motheaten (me/me), and the allelic viable motheaten (me(v)/me(v)) mice. Since HCP is expressed in many cell types and protein phosphorylation is a major mechanism of regulating protein function, it is not surprising that the motheaten phenotype is pleiotropic. It is commonly thought that immune system involvement causes this disease. If so, the motheaten disease ought to be alleviated when the recombination activation gene-1 (RAG-1) is disrupted because there will be no V(D)J rearrangement and thus impaired development of B and T cells. We bred homozygous, double-mutant me(v)/me(v) x RAG 1 -/- mice and found that, in fact, inflamed paws, and splenomegaly with elevated myelopoiesis. Thus, except for autoantibodies, the motheaten phenotype does not depend on the presence of B and T cells. This observation cautions the use of motheaten mice as a model of autoimmune disease.
Individualized Hormone-Replacement Therapy?
Authors: Ronald M. Krauss
Journal: New England Journal of Medicine (2002)

For many years, the conventional wisdom, backed by observational epidemiologic studies, has held that “replacement” of estrogen after menopause would restore the relative protection from cardiovascular disease enjoyed by premenopausal women as compared with men of a similar age. This view was bolstered by a number of apparently beneficial effects of oral estrogen therapy on risk factors for cardiovascular disease, most notably reductions in the level of low-density lipoprotein (LDL) cholesterol and increases in the level of high-density lipoprotein (HDL) cholesterol. Recent clinical trials, however, have failed to support a benefit of hormone-replacement therapy in terms of clinical events1 and . . .
Chronic Granulomatous Disease 1974
Authors: Richard K. Root
Journal: JAMA (1975)

<h3>To the Editor.—</h3> I read with interest the article by Dr Schlegel on "Chronic Granulomatous Disease 1974" (231:615, 1975). For the sake of setting the record straight, it is worthwhile to note that patients with the Chédiak-Higashi syndrome do not have a "predilection to infection secondary to deficient phagocytosis." Rather, they have combined defects in<i>chemotaxis</i>as noted in the article by Clark and Kimball<sup>1</sup>(Schlegel's reference 20) and<i>intracellular killing</i>of ingested bacteria due to deficient degranulation of their giant lysosomes<sup>2</sup>as well as neutropenia.<sup>3</sup>Phagocytosis by Chédiak leukocytes is normal to increased.<sup>4</sup> Also, the patient described in Schlegel's reference 23 as having increased susceptibility to infection on the basis of a serum inhibitor of chemotaxis has, by all the classical criteria stated by Dr Schlegel, sex-linked chronic granulomatous disease of childhood when studied extensively in my laboratory.<sup>2,5</sup>This is probably much more instrumental
Should Physicians Prescribe Religious Activities?
Authors: R P Sloan, E Bagiella, L VandeCreek, M Hover, C Casalone, T Jinpu Hirsch, Y Hasan, R Kreger, P Poulos
Journal: New England Journal of Medicine (2000)

There is increasing interest among the general public and the medical community in the role of religion in medicine. Polls indicate that the U.S. population is highly religious; most people believe in heaven and hell,1 the healing power of prayer,2 and the capacity of faith to aid in the recovery from disease.3 The popular press has published many articles in which religious faith and practice have been said to promote comfort, healing, or both. A report that 77 percent of hospitalized patients wanted physicians to consider their spiritual needs is consistent with this trend.4 Interest in the connection between religion . . .
Secondary Prevention Trials in Alzheimer Disease
Authors: Richard J. Kryscio
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Clinical, epidemiological, and microbiological features of Vibrio vulnificus biogroup 3 causing outbreaks of wound infection and bacteraemia in Israel
Authors: Naiel Bisharat, Vered Agmon, Renato Finkelstein, Raul Raz, Gad Ben-Dror, Larisa Lerner, Soboh Soboh, Raul Colodner, Daniel N Cameron, David L Wykstra, David L Swerdlow, JJ Farmer
Journal: The Lancet (1999)
FLOATING KIDNEY SIMULATING DISEASES OF THE GENITAL ORGANS IN WOMEN.
Authors: A. LAPTHORN SMITH
Journal: JAMA (1899)

By the division of labor and the increasesd attention which each branch of our art thereby receives, mistakes both in diagnosis and treatment are growing fewer year by year. As far as diseases of women are concerned, the writer believes that 95 per cent. of those who submit to treatment are entirely cured; and even this small percentage of failures would be still further reduced if we could eliminate all errors of diagnosis. Floating kidney is one of those diseases which gives rise to so many symptoms which we have been accustomed to attribute solely to the genital organs, that it is no wonder that its presence has often not been recognized, and the patients suffering from it after having undergone one or more gynecologic operations have continued to suffer and complain as much as ever of those reflex disturbances which we thought depended entirely on a laceration or displacement of
Hyperparathyroidism Accompanying Multiple Myeloma
Authors: Nick Patel, Arunabh Talwar, Laura Donahue, Veena John, Donald Margouleff
Journal: Clinical Nuclear Medicine (2005)

Hypercalcemia is a manifestation of a variety of both benign and malignant diseases. These conditions are not mutually exclusive, and we present a case report of a patient first diagnosed with the classic findings of multiple myeloma who, after appropriate therapy, demonstrated persistent hypercalcemia and was found on further testing to have an elevated parathormone level (PTH) and scintigraphic evidence of a benign parathyroid adenoma. Hypercalcemia responded to excision of the parathyroid adenoma. There are only 18 similar cases reported in the medical literature.
EFFECT OF AUTOLYSIS ON POTENCY OF LIVER IN TREATMENT OF PERNICIOUS ANEMIA
Authors: WILLIAM B. CASTLE
Journal: JAMA (1935)

In 1928 one of us investigated the question of whether the hematopoietic activity of mammalian liver and kidney demonstrated in the treatment of pernicious anemia by Minot and Murphy<sup>1</sup>and by McCann<sup>2</sup>was due to processes occurring in these organs after the death of the animal. For technical reasons the experiments were carried out with the pulp of lambs' kidneys in which postmortem autolysis was prevented within two minutes after the death of the animals, by boiling the material for five minutes in acidified water at<i>P</i><sub>H</sub>5. The daily administration to each of two patients with pernicious anemia of about 200 Gm. of such kidney pulp during periods of ten days indicated an unimpaired potency in comparison with that of identical amounts of material prepared in a similar fashion from lambs' kidneys purchased in the market. Because the results of the observations were entirely negative, they
Tracheitis Sicca
Authors: Brock Lynch, Eugene E. Cliffton, John Lewis
Journal: New England Journal of Medicine (1957)

TRACHEITIS sicca is a hazardous state that complicates the well-being of postlaryngectomy patients, as well as others with a tracheostomy tube, especially during the cold winters experienced in northern climates. Crusting, ropy secretions and, in the acutely severe cases, an eroded and bleeding tracheal mucosa are diagnostic. These create a vicious circle in which the patient's coughing produces dyspnea, the dyspnea accentuates the drying process, and the patient is left fighting for a comfortable airway day and night.The onset seems independent of the time elapsed since tracheostomy, and the condition is encountered two days to five years postoperatively. The . . .
Severe hypertension and bronchospasm during disulfiram-ethanol test reaction.
Authors: E. Zapata, A. Orwin
Journal: BMJ (1992)

Cambridge CB3 8RE) write: Papa- verine administered by the intracoronary route in humans produces a brief maximal hyperaemic response in the coronary circulation that has little systemic effect and is used to measure coronary flow reserve in cardiac disease. 2 Intracoronary papaverine is known to produce changes in cardiac electrophysio- logical variables and ST-T configur- ation and prolongation of the QT interval.3Isolated cases of ventricular tachycardia and ventricular fibril- lation have also been described.46We describe a case of complete atrioven- tricular block after intracoronary papaverine administration.A 53 year old man was undergoing investigations for chest pain with a positive response on exercise electro- cardiography and normal coronary arteries on angiography.He was re- admitted for further investigations, including coronary flow reserve studies.He had been taking nifedipine for several months and this was stopped 24 hours before cardiac catheterisation.His only other medication was dipyridamole, which was continued.Baseline pulse rate, blood pressure, electrocardiogram, and serum electolyte concentrations were normal.Resting coronary blood flow was measured with a 3F 20 mHz intracoronary Doppler flow probe.Incremental doses of intracoronary papaverine were given after a 2 mg test dose.After administration of a 12 mg dose the patient developed complete atrioventricular block last- ing five seconds.He remained asymptomatic and was haemo- dynamically stable.The study was terminated because of this unexpected side effect.This case shows that, although papaverine is a relatively safe coron- ary vasodilator for measuring coron- ary flow reserve, all patients should be closely monitored while receiving intracoronary papaverine.A tem- porary pacemaker should also be available as well as appropriate antiarrhythmic preparations.1 Wilson RF, White CW.Intracoronary papa- venne: an ideal coronars vasodilator for studies of the coronary circulation in con- scious humans.
Major basic protein and eosinophil-derived neurotoxin concentrations in nasal-lavage fluid after antigen challenge: Effect of systemic corticosteroids and relationship to eosinophil influx
Authors: R BASCOM, U PIPKORN, D PROUD, S DUNNETTE, G GLEICH, L LICHTENSTEIN, R NACLERIO
Journal: Journal of Allergy and Clinical Immunology (1989)
Quantitative Assessment of the Operative Results After Extended Myectomy and Surgical Reconstruction of the Subvalvular Mitral Apparatus in Hypertrophic Obstructive Cardiomyopathy Using Dynamic Three-Dimensional Transesophageal Echocardiography
Authors: Andreas Franke, Friedrich A Schöndube, Harald P Kühl, Heinrich G Klues, Constantin Erena, Bruno J Messmer, Frank A Flachskampf, Peter Hanrath
Journal: Journal of the American College of Cardiology (1998)
Pesticides, Chloracne, and Porphyria Cutanea Tarda
Authors: Jacob Bleiberg, Roger H. Brodkin
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The terms, 2,4-dichlorophenol and 2,4,5-trichlorophenol, are the commonly accepted designations for the phenoxy acetic acids of these compounds. It makes no difference if the basic compound is acidified or esterified, or synthesized into a salt. The point is that the benzene ring with two or three chlorine atoms attached is involved in the etiology of chloracne and/or symptomatic porphyria cutanea tarda (PCT). These herbicides are indeed useful. We simply pointed out that, at least in their synthesis, toxic side effects are to be looked for. We have had a report, documented with photographs, of chloracne occurring in an agricultural area where the finished phenoxy compound is being used. This was not stressed in the communication, since we were concerned with the occurrence of PCT and chloracne in the manufacture of herbicides.