tbuckley/cabot-search huggingface dataset:
Handbook of Women's Health: An Evidence-Based Approach
Authors: Ellen Schur, Joann Elmore
Journal: Annals of Internal Medicine (2004)

Medical Writings: Book Notes16 November 2004Handbook of Women's Health: An Evidence-Based ApproachEllen Schur, MD and Joann Elmore, MD, MPHEllen Schur, MDFrom Harborview Medical Center, Seattle, Washington.Search for more papers by this author and Joann Elmore, MD, MPHFrom Harborview Medical Center, Seattle, Washington.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-10-200411160-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Handbook of Women's Health: An Evidence-Based Approach Paperback edition. Rosenfeld JA, ed. 628 pages. New York: Cambridge Univ Pr; 2001. $45.00. ISBN 0521545951. Order at www.cup.org.Field of medicine: Women's health.Format: Softcover book.Audience: Health care providers practicing primary care for women.Purpose: To provide a clear and comprehensive evidence-based guide to the care of women in an ambulatory setting.Content: The handbook addresses the care of women throughout the lifespan. Content emphasizes preventive measures, screening, mental health, psychosocial issues, and common gynecologic problems. Several common medical problems, such as hypertension, coronary artery disease, and thyroid disorders, are presented ... Author, Article, and Disclosure InformationAffiliations: From Harborview Medical Center, Seattle, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 November 2004Volume 141, Issue 10Page: 824KeywordsHormone replacement therapyHypertensionObstetrics and gynecologyPreventive medicinePrimary carePsychiatry and mental healthSoftware toolsStable coronary artery diseaseThyroid diseasesTreatment guidelines ePublished: 16 November 2004 Issue Published: 16 November 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
all- <i>Trans</i> -Retinoic Acid Reduces Neointimal Formation and Promotes Favorable Geometric Remodeling of the Rat Carotid Artery After Balloon Withdrawal Injury
Authors: Joseph M. Miano, Louise A. Kelly, Cecilia A. Artacho, Tammy A. Nuckolls, Roseann Piantedosi, William S. Blaner
Journal: Circulation (1998)

The multifactorial and unpredictable nature of human restenosis will probably necessitate interventional strategies that target multiple processes involved in acute vascular narrowing. Retinoids (eg, all-trans-retinoic acid, atRA) represent a growing class of pleiotropic biological response modifiers with demonstrable efficacy in managing several pathological conditions. In this report, we have initiated studies to examine the hypothesis that atRA limits neointimal formation after experimental vascular injury.Rats were predosed with atRA (30 mg . kg-1 . d-1 PO) or corn oil 4 days before balloon withdrawal injury (BWI) of the left common carotid artery and continued on this drug regimen for an additional 14 days. High-performance liquid chromatographic analysis documented therapeutic levels of atRA in serum and vascular tissue. atRA depressed peak DNA synthesis in the tunica media of BWI vessels (P<0.05). Histomorphometry revealed atRA-mediated reductions in neointimal area, neointimal cell number, and intimal/medial area ratio as well as significant increases in vessel wall perimeter (P<0. 05). Such changes in vascular architecture contributed to a 35% to 37% increase in the luminal area of BWI vessels exposed to atRA (P<0. 005 compared with controls).atRA reduces neointimal mass and elicits favorable geometric remodeling of the injured rat carotid artery.
A REVIEW OF THE CONCEPT OF WEBER-CHRISTIAN PANNICULITIS WITH A REPORT OF FIVE CASES
Authors: ANGUS MACDONALD, M. FEIWEL
Journal: British Journal of Dermatology (1968)

SUMMARY. —Five patients with Weber‐Christian panniculitis (W.C.P.) are described. These illustrate the great variability of the clinical course of cases to which this diagnosis is applied. In two (one fatal) no aetiological factor was found, one case was considered to be an artefact, one was related to tuberculosis and another was possibly a manifestation of systemic lupus erythematosus. It is concluded from a survey of the literature and from these 5 cases that W.C.P. is not nosologically distinct and that present terminology suggesting a single disease entity is undesirable. A purely descriptive term like nodular panniculitis should be used while a search is made for aetiological factors. In some cases these may be found to rest on a vascular basis, possibly the result of an immunological process.
Simple Method for Detection of Infection of Peritoneum during Dialysis
Authors: E. N. Wardle
Journal: BMJ (1973)

The lysozyme (muramidase) content of peritoneal fluid samples has been found to be an early indicator of the onset of infection in the course of peritoneal dialysis. A level of 10.0 mug/ml indicates peritoneal infection and one of 7.5 mug/ml is highly suspicious.
"Presbycolon" Problems in the Nursing Home
Authors: Robert D. Gillette
Journal: JAMA (1976)

<h3>To the Editor.—</h3> It may be presumptuous of me to disagree with a writer as distinguished as Eddy D. Palmer, MD, but in my judgment he has made the "presbycolon" problem in nursing homes (235:1150, 1976) appear more hopeless than it really is. There are two characteristics of nursing home patients that must be understood and dealt with. To begin with, many of them (like their noninstitutionalized peers) do not realize that growing older is associated with eating less, having less waste to eliminate, and therefore having less frequent stools than might have been expected at a younger age. For many oldsters, the "problem" disappears with explanation; for others, the desired stools can be produced with bran cereals, pysillium hydrophilic mucilloid with dextrose (Metamucil), or (if one can accept a certain amount of bowel irritation) prunes. A second aspect of the problem arises from the fact that many nursing home
Failure of a Pure Progestogen Contraceptive to Affect Serum Levels of Iron, Transferrin, Protein-bound Iodine, and Transaminase
Authors: L. W. Powell, J. M. Jacobi, T. J. Gaffney, R. Adam
Journal: BMJ (1970)

Medroxyprogesterone acetate, a pure progestational agent which is not metabolized to oestrogen, was given to 30 women and shown to have no effect on the serum levels of iron, total iron-binding capacity, transferrin, and protein-bound iodine. Eighteen of these women had previously taken oral contraceptives of the combined oestrogen-progestogen “sequential” type, and during that time these serum levels were raised. Nevertheless, the levels all fell significantly after medroxyprogesterone acetate was given and the “sequential” oral contraceptive was stopped. In a further 12 postpartum women the serum levels did not change significantly after medroxyprogesterone acetate. These observations strongly suggest that raised plasma protein levels resulting from the administration of oral contraceptives are due to the oestrogen component.
Seasonal variation in coronary artery disease mortality in Hawaii: observational study
Authors: T. B Seto, M. A Mittleman, R. B Davis, D. A Taira, I. Kawachi
Journal: BMJ (1998)

in boys.A tendency for girls to overreport asthma symptoms and boys to deny them may have overestimated the size of the sex difference.However, the effect persisted when we used parental responses and also when we restricted the analysis to current wheezers with a doctor's diagnosis of asthma, both of which measures may be less affected by sex.We found no difference in response rates among boys or girls of different ages except for slightly lower rates by both sexes in year 11, which would not have affected the overall trend.Parental response rates did fall with age, but this does not appear to have biased the estimates since the pattern of parent reported prevalence is similar to that of self reported prevalence.It therefore seems unlikely that the sex effect is solely the result of reporting or selection bias.Hormonal changes occurring in early puberty could have a role in the changing prevalences.Troisi et al reported a positive dose-response relation between oestrogen use and the risk of adult onset asthma in women. 3Also there is evidence that girls are more likely than boys to develop asthma in adolescence, 4 which could be hormone related or due to girls experiencing different exposures to triggers for wheeze at this age, such as smoking.The decrease in wheezing prevalence in boys may be related to the increase in size of airways, which are on average smaller than those of girls in infancy. 5 The effects of hormones and other factors operating during early adolescence on measures of airway inflammation and other markers of asthma deserve further investigation.
Malaria Vaccine Clue
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1037 BMP7 PROTEIN AND BMP1-3 ANTIBODY PREVENT DEVELOPMENT AND PROMOTE REGRESSION OF CCL4-INDUCED LIVER FIBROSIS IN RATS
Authors: I. Grgurevic, I. Erjavec, L. Grgurevic, S. Prgomet, S. Krizanac, R. Heinzl, Z. Romic, A. Unic, M. Petrovecki, M. Kujundzic, S. Vukicevic
Journal: Journal of Hepatology (2011)
The Psychiatric Symptoms of Rheumatic Fever
Authors: Marcos T. Mercadante, Geraldo F. Busatto, Paul J. Lombroso, Lísia Prado, Maria C. Rosário-Campos, Raquel do Valle, Maria J. Marques-Dias, Maria H. Kiss, James F. Leckman, Euripedes C. Miguel
Journal: American Journal of Psychiatry (2000)

OBJECTIVE: This study examined the frequency and age at onset of psychiatric disorders among children with rheumatic fever, Sydenham's chorea, or both and a comparison group. METHOD: Twenty children with rheumatic fever, 22 with Sydenham's chorea, and 20 comparison children were assessed by means of a semistructured interview and rating scales for tic disorders and obsessive-compulsive disorder. RESULTS: Obsessive-compulsive symptoms were more frequent in both the Sydenham's chorea and rheumatic fever groups than in the comparison group. The Sydenham's chorea group had a higher frequency of major depressive disorder, tic disorders, and attention deficit hyperactivity disorder (ADHD) than both the comparison and rheumatic fever groups. ADHD symptoms were associated with a higher risk of developing Sydenham's chorea. CONCLUSIONS: Both the rheumatic fever and Sydenham's chorea groups were associated with a higher risk of developing neuropsychiatric disorders than the comparison group. ADHD appears to be a risk factor for Sydenham's chorea in children with rheumatic fever.
Effect of Hemodialysis on Gallium-67-Citrate Scanning
Authors: JULIA M. MARLETTE, KING WAI, REX B. SHAFER
Journal: Clinical Nuclear Medicine (1980)

Gallium-67-citrate scanning is often used in the diagnosis of inflammatory processes in hemodialysis patients. The question arises whether the dialysis process will adversely affect the quality of the gallium scan. To answer this question, nine dialysis patients were studied, eight on hollow-fiber dialysis units and one on ultrafiltration, in an attempt to quantitate the loss of gallium through dialysis. Blood sampling during dialysis failed to demonstrate changes in gallium concentration attributable to removal by dialysis. Sampling of dialysate demonstrated levels of activity significantly greater than background; however, quantitation was not reliable. Ultrafiltration with total collection of extracted fluids yielded 0.5% of injected dose removed from the blood. Whole-body scans at 24 hours postinjection showed good quality and total counts unaltered by dialysis. The time of injection prior to dialysis also showed no effect on the quality of the final image.
Lung function 22-35 years after treatment of idiopathic spontaneous pneumothorax with talc poudrage or simple drainage.
Authors: P Lange, J Mortensen, S Groth
Journal: Thorax (1988)

The long term effects on lung function of treatment of idiopathic spontaneous pneumothorax by talc poudrage or simple chest drainage were assessed in 114 patients. Subjects were studied 22-35 years after their first pneumothorax with measurement of static and dynamic lung volumes. Eighty patients had been treated with talc pleurodesis and 34 with simple pleural drainage. At the follow up examination 17 had died from what appear to be unrelated causes and two had emigrated. Of the remainder, 75 participated fully in the study, 14 completed a postal questionnaire, and six failed to respond. The group treated with talc poudrage showed a mild restrictive impairment of lung function with a mean total lung capacity (TLC) of 89% predicted. In subjects treated with simple drainage mean TLC was 96% predicted. One subject treated with talc poudrage had extensive pleural calcification and a substantial reduction in lung function (TLC 58% predicted) with some evidence of lung fibrosis. None of the subjects had developed a mesothelioma. We conclude that, although talc poudrage may cause a mild restrictive impairment of lung function and pleural thickening on the chest radiograph, the long term outlook is good.
Serum Selenium and Subsequent Risk of Cancer Among Finnish Men and Women
Authors: P. Knekt, A. Aromaa, J. Maatela, G. Alfthan, R.-K. Aaran, M. Hakama, T. Hakulinen, R. Peto, L. Teppo
Journal: JNCI Journal of the National Cancer Institute (1990)

The association between the serum selenium level and the subsequent incidence of cancer was investigated in a longitudinal study of 39,268 men and women participating in the Social Insurance Institution's Mobile Clinic Health Examination Survey in Finland. The baseline examinations, including the collection of blood samples, were performed in 1968-1972. During a median follow-up of 10 years, 1,096 new cancer cases were identified from the files of the Finnish Cancer Registry. Selenium concentrations were measured from the stored serum samples collected from these cancer cases and from two controls per case, matched for sex, municipality, and age. The mean serum selenium level was 59.1 micrograms/L among all male cancer cases and 62.5 micrograms/L among controls. The difference was statistically significant (P less than .001). Corresponding values among women were 63.6 and 63.9 micrograms/L, respectively. Low serum selenium levels were associated with an increased risk of developing cancer at several sites, especially cancers of the stomach and lung among men. The relative risk of lung cancer between the highest and lowest decile of serum selenium was 0.11, and it differed significantly from unity (P less than .001). These findings are in agreement with the hypothesis that low selenium intake may increase the risk of some cancers among men.
Basal-Rate Intravenous Insulin Infusion Compared to Conventional Insulin Treatment in Patients With Type II Diabetes: A Prospective Crossover Trial
Authors: Perry J Blackshear, Anne M Roussell, Alfred M Cohen, David M Nathan
Journal: Diabetes Care (1989)

We compared continuous basal-rate intravenous insulin infusion, delivered by means of a totally implantable pump, to two types of conventional insulin administration in patients with type II (non-insulindependent) diabetes in a prospective crossover trial. Ten patients entered the study, and 5 completed all three 8-mo study periods. When results from the infusion study period were compared with results from the periodinvolving single daily injections of ultralente insulin, significant improvements were noted in the pump arm in glycosylated hemoglobin concentrations (which were nearly normal), M-component values, mean daily outpatient fasting blood glucose concentrations, mean fasting and 24-h blood glucose concentrations during an inpatient 24-h glycemic profile, and urinary glucose concentrations. When the pump arm was compared to a period of single daily injections of lente insulin, three of six monthly mean fastingblood glucose concentrations and overall means for the entire study period were significantly lower during the pump arm than during the lente arm; in addition, significantly fewer hypoglycemic reactions were noted during infusion therapy than during lentetherapy. Finally, mealtime free-insulin and C-peptide excursions appeared to be greater during infusion treatment when compared with lente or ultralente treatment. In the 50% of patients who completed the study, it appeared that significant improvements in glycemic control could be achieved by simple basal-rate intravenous insulin infusion compared with conventional treatment with single daily injections of ultralente or lente insulin without an increased incidence of symptomatic hypoglycemia.
Teaching First Aid
Authors: F. J. Curtis
Journal: BMJ (1949)

ABSTRACT. Prevention or retardation of diabetic nephropathy (DN) includes anti-hypertensive treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II type 1 receptor blockers (ARB) on the premises that these drugs have an added protective effect beyond their influence on BP. The present study used a strain of spontaneously hypertensive/NIH-corpulent rats [SHR/NDmc-cp (fat/fat)] as a model of type II DN to unravel the renoprotective effects of anti-hypertensive drugs. Olmesartan (1 or 5 mg/kg per d), an ARB, and hydralazine (5mg/kg per d), an anti-hypertensive drug without effect on the renin-angiotensin system (RAS), were given for 20 wk. BP, renal function, glucose and insulin levels, and proteinuria were monitored. Glomerular lesions and kidney pentosidine content were assessed at the end of the study. Olmesartan (1 and 5 mg) significantly reduced BP and kidney pentosidine content and improved histologic renal damage and proteinuria. The changes were dose-dependent. The effect of hydralazine (5 mg) was similar to that of olmesartan (1 mg) but reached statistical significance only for kidney pentosidine content. The similarity of both drugs’ effects on kidney damage and proteinuria suggest that renoprotection does not hinge on manipulation of RAS in these rats. By contrast, the inhibition of renal pentosidine formation assessed both by immunohistochemistry and HPLC suggests a critical role of advanced glycation end product (AGE) formation together with hypertension in the genesis of diabetic nephropathy. This view is supported by the correlation found between renal pentosidine content and proteinuria. The unsuspected AGE-lowering effect of hydralazine was further confirmed <i>in vitro</i> and elucidated; it is due to both reactive carbonyl compounds trapping and modifications of the oxidative metabolism. It is concluded that AGE inhibition should be included in the therapeutic strategy of DN. E-mail: t-miyata@is.icc.u-tokai.ac.jp
The game of word skipping: Who are the competitors?
Authors: Ralf Engbert, Reinhold Kliegl
Journal: Behavioral and Brain Sciences (2003)

Computational models such as E-Z Reader and SWIFT are ideal theoretical tools to test quantitatively our current understanding of eye-movement control in reading. Here we present a mathematical analysis of word skipping in the E-Z Reader model by semianalytic methods, to highlight the differences in current modeling approaches. In E-Z Reader, the word identification system must outperform the oculomotor system to induce word skipping. In SWIFT, there is competition among words to be selected as a saccade target. We conclude that it is the question of competitors in the “game” of word skipping that must be solved in eye movement research.
Why clinicians are natural bayesians
Authors: Christopher J Gill, Lora Sabin, Christopher H Schmid
Journal: BMJ (2005)

Thought you didn't understand bayesian statistics?Read on and find out why doctors are expert in applying the theory, whether they realise it or not Two main approaches are used to draw statistical inferences: frequentist and bayesian.Both are valid, although they differ methodologically and perhaps philosophically.However, the frequentist approach dominates the medical literature and is increasingly applied in clinical settings.This is ironic given that clinicians apply bayesian reasoning in framing and revising differential diagnoses without necessarily undergoing, or requiring, any formal training in bayesian statistics.To justify this assertion, this article will explain how bayesian reasoning is a natural part of clinical decision making, particularly as it pertains to the clinical history and physical examination, and how bayesian approaches are a powerful and intuitive approach to the differential diagnosis.Every part of clinical history and examination can be viewed as a diagnostic test
Controlling glucose and blood pressure in type 2 diabetes
Authors: J. Tuomilehto
Journal: BMJ (2000)

Papers pp 405, 412 

Strategies for treating disorders of public health interest such as high blood pressure, dyslipidaemia, and hyperglycaemia have been debated ever since they were considered to be conditions for medical interventions. The main questions have been when should we start treatment, what is the target level during treatment, and what is the best method of treatment? Since there are no obvious cut-off points for blood pressure or glucose or cholesterol concentrations that would guide clinical decisions, the justification must come from clinical and epidemiological research.

Data from randomised clinical trials are considered necessary these days for defining treatment practice, but there are limits on the generalisability of their results.1 These results are important in proving causality between risk factors and outcomes and in showing the reversibility of the disease process by therapy. Observational data, on the other hand, are needed to describe the target population included in the trials and thus to …
Probable Herpes Simplex Pneumonia After Aortic Valve Replacement
Authors: Robert H. Breyer
Journal: JAMA (1983)

Herpesvirus pneumonia developed in a 68-year-old man after aortic valve replacement and two-vessel aortocoronary bypass. The complication was fatal, and the diagnosis was made only after death. The source of the herpesvirus could not be determined.
SOME OBSERVATIONS ON THE DEVELOPMENT OF HYPOKALIEMIA DURING THERAPY OF DIABETIC ACIDOSIS IN JUVENILE AND YOUNG ADULT SUBJECTS
Authors: L. Greenman, F. M. Mateer, R. C. Gow, J. H. Peters, T. S. Danowski
Journal: Journal of Clinical Investigation (1949)

It is known that hypopotassemia may appear during therapy of diabetic acidosis or coma, at times associated with muscular paralysis (1-9).This is not, however, an invariable occurrence, nor have the origins of such decreases in the serum and interstitial fluid potassium concentrations been clearly defined.It seems probable that one or more mechanisms are responsible.These include