Novel Presentation of Acute Myelogenous Leukemia as Symptomatic Galactorrhea
Authors: Noel Ales, Joseph Flynn, John C. Byrd
Journal: Annals of Internal Medicine (2001)

Letters21 August 2001Novel Presentation of Acute Myelogenous Leukemia as Symptomatic GalactorrheaNoel Ales, MD, Joseph Flynn, DO, and John C. Byrd, MDNoel Ales, MDWalter Reed Army Medical Center, Washington, DC 20307 (Ales, Flynn)The Ohio State University, Columbus, OH 43210 (Byrd), Joseph Flynn, DOWalter Reed Army Medical Center, Washington, DC 20307 (Ales, Flynn)The Ohio State University, Columbus, OH 43210 (Byrd), and John C. Byrd, MDWalter Reed Army Medical Center, Washington, DC 20307 (Ales, Flynn)The Ohio State University, Columbus, OH 43210 (Byrd)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-4-200108210-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Acute myelogenous leukemia (AML) is the most common acute leukemia in adults (1). The French-American-British classification AML-M5, monocytic leukemia, is commonly associated with extramedullary disease (2). Acute myelogenous leukemia is often associated with elevated levels of cytokines or hormones, such as prolactin (3). These rarely manifest with clinical symptoms. Indeed, despite the high frequency of elevated prolactin levels in leukemic myeloblasts in one series, no patients with AML and symptomatic galactorrhea have been described (4).We evaluated a 21-year-old woman who had had fatigue and galactorrhea for 1 month. Physical examination was notable for gingival hyperplasia, oral ...References1. Sandler DP. Epidemiology of acute myelogenous leukemia. Semin Oncol. 1987;14:359-64. [PMID: 0003321440] MedlineGoogle Scholar2. Fava GA, Lisansky J, Buckman MT, Kellner R, Pathak D, Fava M, et al . Prolactin, cortisol, and antidepressant treatment. Am J Psychiatry. 1988;145:358-60. [PMID: 0003344852] CrossrefMedlineGoogle Scholar3. Pellegrini I, Lebrun JJ, Ali S, Kelly PA. Expression of prolactin and its receptor in human lymphoid cells. Mol Endocrinol. 1992;6:1023-31. [PMID: 0001508218] MedlineGoogle Scholar4. Hatfill SJ, Kirby R, Hanley M, Rybicki E, Bohm L. Hyperprolactinemia in acute myeloid leukemia and indication of ectopic expression of human prolactin in blast cells of a patient of subtype M4. Leuk Res. 1990;14:57-62. [PMID: 0001968111] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Walter Reed Army Medical Center, Washington, DC 20307 (Ales, Flynn)The Ohio State University, Columbus, OH 43210 (Byrd) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byParaneoplastic Galactorrhea in Childhood T-ALL: An Evaluation of Tumor-derived ProlactinAcute Myeloid Leukemia Presenting as GalactorrheaAcute myeloid leukaemia presenting as galactorrhoeaProlactin and the Immune SystemRegulation of prolactin expression in leukemic cell lines and peripheral blood mononuclear cells 21 August 2001Volume 135, Issue 4Page: 303-304KeywordsAcute monocytic leukemiaAcute myeloid leukemiaChemotherapyLuteinizing hormoneMagnetic resonance imagingPathogenesisPlateletsProlactinThyroid-stimulating hormoneTransplantation ePublished: 21 August 2001 Issue Published: 21 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...