tbuckley/cabot-search huggingface dataset:
Can intramuscular lipoma have a post-traumatic origin?
Authors: E. Copcu
Journal: British Journal of Dermatology (2003)

British Journal of DermatologyVolume 149, Issue 5 p. 1084-1085 Can intramuscular lipoma have a post-traumatic origin? E. Copcu, E. Copcu Department of Plastic and Reconstructive Surgery, Medical Faculty, Adnan Menderes University, 09100 Aydin, Turkey E-mail: copcu@lycos.comSearch for more papers by this author E. Copcu, E. Copcu Department of Plastic and Reconstructive Surgery, Medical Faculty, Adnan Menderes University, 09100 Aydin, Turkey E-mail: copcu@lycos.comSearch for more papers by this author First published: 24 November 2003 https://doi.org/10.1111/j.1365-2133.2003.05615.xCitations: 12Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume149, Issue5November 2003Pages 1084-1085 RelatedInformation
CDw60, which identifies the acetylated form of GD3 gangliosides, is strongly expressed in human basal cell carcinoma
Authors: M. HEIDENHEIM, E.R. HANSRN, O. BAADSGAARD
Journal: British Journal of Dermatology (1995)

The monoclonal antibody UM4D4, assigned to the CDw60 cluster of differentiation, identifies an epitope expressed on a subset of normal T cells, some malignant T cells, melanocytes, malignant melanoma cells and hyperproliferative psoriatic keratinocytes. CDw60 antibodies bind to the acetylated form of GD3 gangliosides. These gangliosides have been implicated in the control of cellular proliferation. Because the acetylated form of GD3 has been demonstrated in basal cell carcinomas, we determined whether the CDw60 epitope was expressed in basal cell carcinomas (n = 24) and squamous cell carcinomas (n = 2). Biopsies of these tumours were sectioned on a cryostat, and stained with anti-CDw60 using a sensitive indirect immunoperoxidase technique. A mean of 74 +/- 4% (mean +/- SEM) of the basal cell carcinoma cells expressed CDw60. In contrast, CDw60 expression in normal skin was confined to melanocytes and a few scattered keratinocytes at the basal cell layer. CDw60 expression in basal cell carcinomas was highly upregulated at the tumour front in most of the lesions, whereas the squamous cell carcinomas showed uniform CDw60 expression in all areas.
Value of Unique Device Identification in the Digital Health Infrastructure
Authors: Natalia A. Wilson, Joseph Drozda
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of a pneumonia practice guideline in an interventional trial.
Authors: S R Weingarten, M S Riedinger, P Hobson, M S Noah, B Johnson, G Giugliano, J Norian, M J Belman, A G Ellrodt
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

There are few available data to define the medically necessary duration of stay for patients hospitalized with pneumonia. Therefore, we investigated the safety and effectiveness of a practice guideline that provided information about switching patients from parenteral to oral antimicrobials and early hospital discharge. The study was a prospective controlled study with an alternate month design. The practice guideline was studied in 146 "low-risk" pneumonia patients hospitalized during a 22-month period. Medical care consistent with the practice guideline occurred in 64% and 76% of patients during control and intervention periods, respectively (p=0.15). There were no differences in patient outcomes in the control and intervention groups when measured 1 mo after hospital discharge, including hospital readmission rates, health-related quality of life, and patient satisfaction. Explicit and implicit review revealed that 98.6% (95% confidence interval [CI]: 95.1%, 99.8%) of low-risk patients would not have benefited from continued hospitalization after the fourth hospital day. The 30-d survival rate of the low-risk pneumonia patients was 99.3% (95% CI: 96.2%, 100%) and patient outcomes appeared to be favorable compared with previously published values. We conclude that duration of hospital stay was frequently consistent with the practice guideline in both study groups, and patient outcomes remained unchanged. The guideline will require additional testing before it can be recommended for use.
Microangiography of the Pulmonary Arterial System in "Hypoplastic Left Heart Syndrome"
Authors: CRAWFORD A. GRANT, BENGT ROBERTSON
Journal: Circulation (1972)

Microangiographic examination of the pulmonary arterial system in 12 newborn infants with concomitant stenosis or atresia of the aortic and mitral orifices showed that the intrapulmonary arterial pattern is influenced by the state of the foramen ovale. In infants with aortic atresia with a prematurely closed foramen ovale, that is cases in which the left side of the heart is a cul-de-sac, there is moderate or prominent tortuosity of the intralobular pulmonary arteries indicating congenital pulmonary hypertension. This feature is less prominent or absent in infants with valvular insufficiency of the foramen ovale, regardless of the postnatal age of the patient.
Some Effects of Nitroglycerin upon the Splanchnic, Pulmonary, and Systemic Circulations
Authors: M. IRENÉ FERRER, STANLEY E. BRADLEY, HENRY O. WHEELER, YALE ENSON, RUDOLPH PREISIG, PHILIP W. BRICKNER, RICHARD J. CONROY, RÉJANE M. HARVEY
Journal: Circulation (1966)

Splanchnic, pulmonary, and systemic hemodynamics were studied in 18 patients after the sublingual administration of nitroglycerin. The drug, contrary to expectations, produced an over-all vasoconstrictive effect on the splanchnic circulation rather than vasodilatation. There was no evidence of venous pooling in this bed, and indeed the data may indicate a splanchnic supportive role in augmenting venous return to the heart with disengorgement of its own volume. In contrast, there was vasodilatation and pooling of blood in the pulmonary vascular bed. The systemic circulation probably sustains several effects by nitroglycerin, including arterial vasodilatation. A direct change in large artery distensibility probably explains the modest fall in systolic blood pressure seen. Further decline in arterial pressure may depend on venous pooling of a small or large degree. Probably the fall in systemic and specific organ flows is also linked to decreased venous return and the vascular readjustments provoked thereby. Pulsus alternans was produced by nitroglycerin, a previously unreported effect of the drug, but the mechanism by which it arose could not be defined.
Protein marker linked with poor cancer outcome
Authors: S. Mayor
Journal: BMJ (1997)

There are new hopes of a reliable indicator for the aggressiveness of tumour cells as three independent studies show that low amounts of p27–a protein that inhibits the cell cycle–are associated with poor survival in breast and colorectal carcinoma.

All three studies were reported in this month's Nature Medicine (1997;3:222-5;227-30;231-4). One study of 168 cases of primary breast cancer showed that low nuclear expression of p27 was a significant predictor of poor disease free survival. Researcher Dr Joyce Slingerland, …
Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome
Authors: Beatrijs M. Lodde, Fumi Mineshiba, Jianghua Wang, Ana P. Cotrim, Sandra Afione, Paul P. Tak, Bruce J. Baum
Journal: Annals of the Rheumatic Diseases (2005)

Sjögren's syndrome (SS), an autoimmune exocrinopathy mainly affecting lachrymal and salivary glands, results in ocular and oral dryness (keratoconjunctivitis sicca and xerostomia). The aetiology and pathogenesis are largely unknown; currently, only palliative treatment is available.To determine whether gene transfer of vasoactive intestinal peptide (VIP), based on its immunomodulatory properties, might be useful in the management of SS.A recombinant serotype 2 adeno-associated virus encoding the human VIP transgene (rAAV2hVIP) was constructed and its efficacy tested in the female non-obese diabetic (NOD) mouse model for SS after retrograde instillation in submandibular glands (SMGs). 10(10) particles/gland of rAAV2hVIP or rAAV2LacZ (encoding beta-galactosidase; control vector) were administered at 8 weeks of age (before sialadenitis onset). Salivary flow rates were determined before vector delivery and at time of death (16 weeks). After death, saliva, serum, and SMGs were harvested. Salivary output, inflammatory infiltrates (focus scores), VIP protein expression, cytokine profile, and serum anti-VIP antibodies were analysed.rAAV2hVIP significantly improved the salivary flow, increased SMG and serum expression of VIP, and reduced SMG cytokines interleukin (IL) 2, IL10, IL12 (p70), and tumour necrosis factor alpha, and serum RANTES, compared with the control vector. No difference in focus scores or apoptotic rates was found; neutralising antibodies were not detected.Local delivery of rAAV2hVIP can have disease modifying and immunosuppressive effects in SMGs of the NOD mouse model of SS. The new strategy of employing VIP prophylactically may be useful for both understanding and managing the salivary component of SS.
Relation between Mycoplasmas and Leukaemia and Related Diseases
Authors: R. J. Fallon, D. K. Jackson
Journal: BMJ (1968)

Forty-five bone marrow specimens from leukaemia patients and 40 marrows from nonleukaemia patients were cultured for mycoplasmas. No mycoplasmas were isolated. Sera from patients with leukaemia or reticuloses and from non-leukaemic subjects were examined for antibodies to the Negroni and 880 strains of Mycoplasma pulmonis and also to the K7, K10, and prototype (PG18) strains of M. fermentans. No significant differences were observed between the two groups of patients with respect to antibodies to these mycoplasmas. These findings support those of the majority of other workers in failing to show any relationship between mycoplasmas and neoplastic disease in man.
Asthma on Tristan da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group.
Authors: N Zamel, P A McClean, P R Sandell, K A Siminovitch, A S Slutsky
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Although asthma has a significant heritable component, the mode of inheritance remains controversial because of the complexity of the disease and the influence of environmental factors. Isolated, inbred populations serve to reduce variability, thus increasing the probability of gene localization. We studied the inbred population of the remote island of Tristan da Cunha to document asthma prevalence for the purpose of genetic linkage analysis. Medical histories and skin atopy were determined on 282 islanders, representing 97% of the population, and airway responsiveness was measured in 254; 226 by methacholine challenge (tidal breathing method) and 28 by bronchodilator response (400 micrograms salbutamol aerosol). Blood samples were collected from 275 islanders. Participants ranged in age from 3 to 94 yr. Asthma was defined as increased airway responsiveness (AR+: PC20 < 4 mg/ml or > or = 15% increase in FEV1 postbronchodilator) combined with a positive history (Hx+). Fifty-seven percent of the islanders had at least partial evidence of asthma (Hx+ and/or AR+) and 23% had a definitive diagnosis of asthma (AR+ with Hx+). Overall 47% of the population were atopic, atopy was proportionally higher in asthmatics (74%) than nonasthmatics (32%; p < 0.01). Analysis of the methacholine dose-response curves demonstrated that asthmatics were significantly (p < 0.01) more responsive than those with AR+ only, and nonasthmatics (AR-, Hx-) were more responsive than laboratory control subjects (p < 0.05), suggesting that these islanders may also carry an airway hyperresponsiveness gene. A frequency plot of the percent fall in FEV1 for all Hx- subjects compared with control data suggests a bimodal distribution consistent with a major gene mechanism for airway responsiveness. Genealogy mapping revealed that the islanders are direct descendants of the 15 original settlers, and historical records suggest at least two founders may have been asthmatic. The data confirm previous reports of a high asthma prevalence on Tristan and support the postulate that this prevalence is a result of gene enrichment occurring in isolated populations by virtue of extensive inbreeding and a probable founder effect.
Assessment of serum myeloperoxidase in children with bronchial asthma
Authors: E Tauber, Y Herouy, R Urbanek, R Urbanek, M Goetz, E Hagel
Journal: Allergy (1999)

Background : The role of neutrophils and myeloperoxidase (MPO) – assumed to be a marker of neutrophil activation – in bronchial asthma is still unclear, and the literature is controversial. Methods : To investigate the participation of neutrophils and their products in childhood asthma, we assessed neutrophil counts and serum MPO in 175 children with bronchial asthma. Ninety of them were asymptomatic, and 85 of them were symptomatic within the last 2 weeks before examination. Bacterial infection of the lower respiratory tract (LRTI) was present in 34 and viral infection in 49 patients. As controls, 45 patients with cystic fibrosis, 23 patients with bacterial LRTI, and 87 healthy children were recruited. Results : Median neutrophil counts (3135 cells/μl) and serum MPO levels (352 μg/l) were not different in children with bronchial asthma from healthy controls (2220 cells/μl and 401 μg/l, respectively), whereas in patients with cystic fibrosis and bacterial LRTI, neutrophil counts and MPO levels were increased. Asthmatic children with bacterial infection had significantly higher serum MPO and neutrophil counts then asthmatic children with viral infection or without infection. In addition, a significant correlation was found between serum MPO and neutrophil counts and C‐reactive protein (CRP), and between neutrophil counts and CRP, but no relationship was detected for serum MPO and disease activity or lung function. Conclusions : Our data indicate that serum MPO – a marker of neutrophil activation – does not contribute to the assessment of the inflammatory process in childhood asthma. In addition, measurement of serum MPO appears not to be useful in assessing the participation of the neutrophil in asthmatic children. However, assessment of MPO may be useful to distinguish between bacterial and viral infection. Abbreviations. BAL: bronchoalveolar lavage; CF: cystic fibrosis; CRP: C‐reactive protein; ECP: eosinophil cationic protein; EPX: eosinophil protein X; LRTI: lower respiratory tract infection; MPO: myeloperoxidase.
995 A COMPARATIVE STUDY BETWEEN ULTRASOUND EVALUATION, LIVER STIFFNESS MEASUREMENT AND BIOPSY FOR STAGING OF HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC LIVER DISEASE
Authors: S. Gaia, C. Cocuzza, E. Rolle, E. Bugianesi, P. Carucci, E. Vanni, A. Evangelista, M. Rizzetto, F. Brunello
Journal: Journal of Hepatology (2009)
Noninterference of Oxazepam, Tranxene-4306CB, and Nordiazepam With Serum Glucose Determinations
Authors: Lawrence T. Sennello
Journal: JAMA (1973)

To the Editor.—  A letter in The Journal (215:1986, 1971) by Zileli et al described an attempted suicide by oxazepam overdose, resulting in simulated nonketoacidotic diabetic coma. The authors attributed an apparent blood glucose level of 1,680 mg/100 ml to interference of circulating oxazepam with glucose determinations. The specific analytical procedure used to determine the serum was not mentioned. The authors mixed one tablet of oxazepam (10 mg) with 2 ml of distilled water and subjected the clear supernatant to glucose determinations by the Somogyi method and the glucose oxidase reaction. Glucose concentrations of 750 and 590 mg/100 ml were found, respectively.  To corroborate these data, a series of samples were prepared to contain 5, 10, and 20μg/ml of nordiazepam, chlorazepate dipotassium (Tranxene), and oxazepam, as well as the contents of one oxazepam (Serax) capsule dissolved in 5 ml of serum. These ten samples, as well as a blank from
Screening the Blood Supply for West Nile Virus RNA by Nucleic Acid Amplification Testing
Authors: Michael P. Busch, Sally Caglioti, Eugene F. Robertson, Joan D. McAuley, Leslie H. Tobler, Hany Kamel, Jeffrey M. Linnen, Venkatakrishna Shyamala, Peter Tomasulo, Steven H. Kleinman
Journal: New England Journal of Medicine (2005)

The use of nucleic acid amplification tests of "minipools" of 16 samples to screen blood donors for West Nile virus RNA began in July 2003. We report the yield and characteristics of positive donations and the incremental yield and safety of nucleic acid amplification tests of individual donations.
A8.16 T helper lymphocytes and monocytes as biosensors of type I interferon responses in viral infection and autoimmunity
Authors: Chieko Kyogoku, Biljana Smiljanovic, Joachim R Grün, Ursula Schulte-Wrede, Tobias Alexander, Robert Biesen, Falk Hiepe, Thomas Häupl, Andreas Radbruch, Andreas Grützkau
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Immune responses in viral infections and autoimmunity are characterised by type I interferon (IFN) gene signatures detectable in peripheral blood mononuclear cells (PBMC). We have identified cell-specific IFN signatures in CD4 T cells and in monocyte subsets and could use them to discriminate between physiologic and pathologically sustained type I responses in yellow fever vaccinated individuals and in systemic lupus erythematosus patients (SLE). In this study we show that these cell-specific IFN signatures are not only working in isolated cell subsets but are even robust enough to classify PBMC in viral infection and autoimmunity. <h3>Materials and Methods</h3> We have used whole genome expression arrays to identify cell-specific type I IFN response signatures in isolated CD4 lymphocytes, CD16<sup>+</sup> and CD16<sup>-</sup> monocyte subsets. These signatures were used to classify independent PBMC samples of yellow fever vaccinated individuals (n = 10) and jSLE patients (n = 10). <h3>Results</h3> 98/165/173 probe sets (CD4+ T cells/CD16- inflammatory Mo/CD16 + resident Mo, respectively, fold change &gt; = 2, &lt; = -2) were detected as a "common" IFN signature observed both in autoimmunity and in immunised ND. 111/164/120 probe sets were detected as an "autoimmune-specific" IFN signature, whereas only 0/8/5 probe sets were detected to be specific for the "virus-induced" IFN signature. Interestingly, these cell-specifically generated expression signatures were successfully used to classify PBMC of viral infection and jSLE by hierarchical cluster analyses. <h3>Conclusion</h3> This study demonstrated that IFN signature in autoimmunity and that in viral infection are quite different in the number of IFN-related genes activated and their expression magnitudes. These cell-specific signatures are robust enough to classify PBMC samples. In summary, "common" and "autoimmune-specific" IFN signature genes are of potential interest as clinical biomarkers in SLE diagnostics to differentiate between a disease flare and a viral infection.
Understanding Diabetes Routines: A Professional Training Exercise
Authors: Elizabeth Warren-Boulton, Wendy F Auslander, Jeanine M Gettinger
Journal: Diabetes Care (1982)

As part of the continuing education programs conducted at the Washington University Diabetes Research and Training Center, 65 health professionals participated in a 4-day simulation exercise which required them to adhere to a diabetic regimen. Instructions covered injections, urine testing, recording results, and calculating and following a meal plan. Evaluation of the simulation focused on the degree of participant adherence to each component, the problems they encountered, and how the experience influenced their patient/clinician interaction. Mean scores for adherence over the 4-day period for each component of the regimen were injections (82%), diet (67%), urine testing (58%), and recording results (56%). Of the total number of adherence problems encountered by the participants, 52% were diet-related, 17% involved urine testing, 17% time constraints, 10% loss of spontaneity, and 4% involved injections. Analysis of the impact of the experience in the work setting indicated improved participant sensitivity to diabetic patient adherence problems and increased ability to effectively counsel patients and family members.
Chilblain lupus erythematosus of Hutchinson responding to surgical treatment: a report of two patients with anti-Ro/SS-A antibodies
Authors: T. AOKI, T. ISHIZAWA, Y. HOZUMI, K. ASO, S. KONDO
Journal: British Journal of Dermatology (1996)

Journal Article Chilblain lupus erythematosus of Hutchinson responding to surgical treatment: a report of two patients with anti‐Ro/SS‐A antibodies Get access T. AOKI, T. AOKI Department of Dermatology, Yamagata University School of Medicine, Iida‐Nishi, Yamagata, 990‐23, Japan Search for other works by this author on: Oxford Academic Google Scholar T. ISHIZAWA, T. ISHIZAWA Department of Dermatology, Yamagata University School of Medicine, Iida‐Nishi, Yamagata, 990‐23, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. HOZUMI, Y. HOZUMI Department of Dermatology, Yamagata University School of Medicine, Iida‐Nishi, Yamagata, 990‐23, Japan Search for other works by this author on: Oxford Academic Google Scholar K. ASO, K. ASO Department of Dermatology, Yamagata University School of Medicine, Iida‐Nishi, Yamagata, 990‐23, Japan Search for other works by this author on: Oxford Academic Google Scholar S. KONDO S. KONDO Department of Dermatology, Yamagata University School of Medicine, Iida‐Nishi, Yamagata, 990‐23, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 3, 1 March 1996, Pages 533–537, https://doi.org/10.1046/j.1365-2133.1996.45767.x Published: 01 March 1996 Article history Accepted: 30 March 1995 Published: 01 March 1996
Recurrent Torsade de Pointes Caused by Atherosclerotic Stenosis in a Single Right Coronary Artery
Authors: Feng Zhang, Juying Qian, Junbo Ge
Journal: Journal of the American College of Cardiology (2011)

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A 65-year-old man with a 6-week history of recurrent syncope owing to torsade de pointes (A) was referred to our institute for cardioverter defibrillator implantation. An electrocardiogram on admission