HIV and Premature Aging: A Field Still in Its Infancy
Authors: Jeffrey Martin, Paul Volberding
Journal: Annals of Internal Medicine (2010)

Editorials5 October 2010HIV and Premature Aging: A Field Still in Its InfancyJeffrey Martin, MD, MPH and Paul Volberding, MDJeffrey Martin, MD, MPHFrom University of California San Francisco, San Francisco, CA 94107; and University of California San Francisco and Veterans Affairs Medical Center, San Francisco, CA 94121.Search for more papers by this author and Paul Volberding, MDFrom University of California San Francisco, San Francisco, CA 94107; and University of California San Francisco and Veterans Affairs Medical Center, San Francisco, CA 94121.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-7-201010050-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Potent antiretroviral therapy has changed the world for most patients with HIV infection, their clinicians, and researchers. Where therapy is available, most patients experience a successful virologic and immunologic response and avoid the opportunistic infections that initially defined the epidemic. However, antiretroviral therapy cannot be considered an unqualified success. In particular, data from treated populations show that lifespan remains shorter compared with uninfected persons, and this diminished lifespan cannot be obviously attributed to any single complication (1, 2). Instead, a growing number of comorbid conditions seem to be more common in HIV-infected patients, and they often occur at younger ages ...References1. Lohse N, Hansen AB, Pedersen G, Kronborg G, Gerstoft J, Sørensen HT, et al. Survival of persons with and without HIV infection in Denmark, 1995-2005. Ann Intern Med. 2007;146:87-95. [PMID: 17227932] LinkGoogle Scholar2. Antiretroviral Therapy Cohort Collaboration. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet. 2008;372:293-9. [PMID: 18657708] CrossrefMedlineGoogle Scholar3. Desquilbet L, Jacobson LP, Fried LP, Phair JP, Jamieson BD, Holloway M, et al; Multicenter AIDS Cohort Study. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci. 2007;62:1279-86. [PMID: 18000149] CrossrefMedlineGoogle Scholar4. McCutchan JA, Wu JW, Robertson K, Koletar SL, Ellis RJ, Cohn S, et al. HIV suppression by HAART preserves cognitive function in advanced, immune-reconstituted AIDS patients. AIDS. 2007;21:1109-17. [PMID: 17502721] CrossrefMedlineGoogle Scholar5. Odden MC, Scherzer R, Bacchetti P, Szczech LA, Sidney S, Grunfeld C, et al. Cystatin C level as a marker of kidney function in human immunodeficiency virus infection: the FRAM study. Arch Intern Med. 2007;167:2213-9. [PMID: 17998494] CrossrefMedlineGoogle Scholar6. Grinspoon SK, Grunfeld C, Kotler DP, Currier JS, Lundgren JD, Dubé MP, et al. State of the science conference: Initiative to decrease cardiovascular risk and increase quality of care for patients living with HIV/AIDS: executive summary. Circulation. 2008;118:198-210. [PMID: 18566320] CrossrefMedlineGoogle Scholar7. Triant VA, Brown TT, Lee H, Grinspoon SK. Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system. J Clin Endocrinol Metab. 2008;93:3499-504. [PMID: 18593764] CrossrefMedlineGoogle Scholar8. Bhavan KP, Kampalath VN, Overton ET. The aging of the HIV epidemic. Curr HIV/AIDS Rep. 2008;5:150-8. [PMID: 18627664] CrossrefMedlineGoogle Scholar9. Effros RB, Fletcher CV, Gebo K, Halter JB, Hazzard WR, Horne FM, et al. Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Clin Infect Dis. 2008;47:542-53. [PMID: 18627268] CrossrefMedlineGoogle Scholar10. Deeks SG, Phillips AN. HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity. BMJ. 2009;338:a3172. [PMID: 19171560] CrossrefMedlineGoogle Scholar11. Shiels MS, Pfeiffer RM, Engels EA. Age at cancer diagnosis among persons with AIDS in the United States. Ann Intern Med. 2010;153:452-60. LinkGoogle Scholar12. Demopoulos BP, Vamvakas E, Ehrlich JE, Demopoulos R. Non-acquired immunodeficiency syndrome-defining malignancies in patients infected with human immunodeficiency virus. Arch Pathol Lab Med. 2003;127:589-92. CrossrefMedlineGoogle Scholar13. Bräu N, Fox RK, Xiao P, Marks K, Naqvi Z, Taylor LE, et al; North American Liver Cancer in HIV Study Group. Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: a U.S.-Canadian multicenter study. J Hepatol. 2007;47:527-37. CrossrefMedlineGoogle Scholar14. Brock MV, Hooker CM, Engels EA, Moore RD, Gillison ML, Alberg AJ, et al. Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care. J Acquir Immune Defic Syndr. 2006;43:47-55. [PMID: 16936558] CrossrefMedlineGoogle Scholar15. Crum-Cianflone NF, Hullsiek KH, Marconi VC, Ganesan A, Weintrob A, Barthel RV, et al; Infectious Disease Clinical Research Program HIV Working Group. Anal cancers among HIV-infected persons: HAART is not slowing rising incidence. AIDS. 2010;24:535-43. [PMID: 19926961] CrossrefMedlineGoogle Scholar16. Frisch M, Biggar RJ, Engels EA, Goedert JJ; AIDS-Cancer Match Registry Study Group. Association of cancer with AIDS-related immunosuppression in adults. JAMA. 2001;285:1736-45. [PMID: 11277828] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jeffrey Martin, MD, MPH; Paul Volberding, MDAffiliations: From University of California San Francisco, San Francisco, CA 94107; and University of California San Francisco and Veterans Affairs Medical Center, San Francisco, CA 94121.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-2011.Corresponding Author: Paul Volberding, MD, 4150 Clement Street, San Francisco, CA 94121; e-mail, paul.volberding@va.gov.Current Author Addresses: Dr. Martin: University of California, San Francisco, 185 Berry Street, Suite 5700, San Francisco, CA 94107.Dr. Volberding: 4150 Clement Street, San Francisco, CA 94121. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAge at Cancer Diagnosis Among Persons With AIDS in the United States Meredith S. Shiels , Ruth M. Pfeiffer , and Eric A. 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Shiels, PhD, MHS, Ruth M. Pfeiffer, PhD, and Eric A. Engels, MD, MPHAssessment of Kidney Safety Parameters Among Hiv-Infected Patients Starting a Tenofovir-Containing Antiretroviral Therapy 5 October 2010Volume 153, Issue 7Page: 477-479KeywordsAgingAIDSCancer risk factorsEpidemiologyHIVHIV infectionsLiverLung and intrathoracic tumorsMedical risk factorsPopulation statistics ePublished: 5 October 2010 Issue Published: 5 October 2010 PDF downloadLoading ...