Antacids and Anticholinergics
Authors: ROBERT C. BARGER
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 August 1975Antacids and AnticholinergicsROBERT C. BARGER, M.S., R.PH., JOHN F. MITCHELL, PHARM.D.ROBERT C. BARGER, M.S., R.PH.Search for more papers by this author, JOHN F. MITCHELL, PHARM.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-2-280_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their recent paper, Littman and Pine (1) stated that "anticholinergics should not be combined with antacids because absorption of the anticholinergic is reduced. . . ." This remark was not referenced, which led to our investigating the clinical significance of this drug interaction.Dotevall and Walan (2) studied the effect of 1-hyoscyamine on duration of antacid action. Antacid administration alone produced a duration of pH ≥ 3 for 28.9 ± 6.1 minutes, while concomitant dosing with the anticholinergic increased this pH limit to 71.1 ± 12.0 minutes (P< 0.01). Morrissey and associates (3), using a...References1. LITTMAN A and PINE B: Antacids and anticholinergic drugs. Ann Intern Med 82:544-551, 1975 LinkGoogle Scholar2. DOTEVALL G and WALAN A: Antacids in the treatment of peptic ulcer. Acta Med Scand 182:529-537, 1967 CrossrefMedlineGoogle Scholar3. MORRISSEY J, HONDA T, and TANAKA Y: Gastric mucosal coating and gastric emptying time of antacids. Arch Intern Med 119: 510-517, 1967 CrossrefMedlineGoogle Scholar4. Antacid therapy for peptic ulcer. Med Lett Drugs Ther 13:93-96, 1971 MedlineGoogle Scholar5. MORRISSEY J and BARRERAS R: Drug therapy: antacid therapy. N Engl J Med 290:550-554, 1974 CrossrefMedlineGoogle Scholar6. Adverse interactions of drugs. Med Lett Drugs Ther 15:77-80, 1973 MedlineGoogle Scholar7. AVERY G: Check-list to potential clinically important interactions. Drugs 5:187-211, 1973 CrossrefMedlineGoogle Scholar8. Evaluations of Drug Interactions, 1st ed. Wash., D.C., American Pharmaceutical Association, 1973 Google Scholar9. HANSTEN P: Drug Interactions, 2nd ed. Philadelphia, Lea & Febiger, 1973 Google Scholar1. GROTE I and WOODS M: Studies on antacids. IV. Adsorption effects of various aluminum antacids upon simultaneously administered anticholinergic drugs. J Am Pharm Assoc 42:319-320, 1953 CrossrefGoogle Scholar2. GROTE I and WOODS M: Studies on antacids. VI. Adsorption effects of various aluminum antacids upon some simultaneously administered synthetic anticholinergic drugs. J Am Pharm Assoc 47:785-786, 1958 CrossrefGoogle Scholar3. BRIMBLECOME R, DUNCAN W, and DURANT G: The pharmacology of Cimetidine, a new histamine H2-receptor antagonist. Br J Pharmacol 53:435-436, 1975 Google Scholar4. BRIMBLECOME R, DUNCAN W, and DURANT G: Cimetidine—a non-thiourea H2-receptor antagonist. J Int Med Res 3: 86-92, 1975 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT C. BARGER, M.S., R.PH.; JOHN F. MITCHELL, PHARM.D.Affiliations: Drug Information Service Providence Hospital Southfield, Michigan 48075 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntacids: physiology versus pharmaceutics 1 August 1975Volume 83, Issue 2Page: 280-281KeywordsDrug interactions ePublished: 1 December 2008 Issue Published: 1 August 1975 PDF downloadLoading ...