The Second-Generation Sulfonylureas: Change or Progress?
Authors: ROBERT A. KREISBERG
Journal: Annals of Internal Medicine (1985)

Editorials1 January 1985The Second-Generation Sulfonylureas: Change or Progress?ROBERT A. KREISBERG, M.D.ROBERT A. KREISBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-125 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo new second-generation sulfonylurea agents, glipizide (Glucatrol; Roerig, New York, New York) and glyburide (Diabeta; Hoechst-Roussel, Somerville, New Jersey; Micronase; Upjohn Company, Kalamazoo, Michigan) have been approved by the Food and Drug Administration for the treatment of patients with type II or non-insulin-dependent diabetes mellitus. What should be our position on their use for type II diabetes in newly diagnosed patients who are eligible for this type of agent, and in established patients whose diabetes is not well controlled with first-generation sulfonylureas?The second-generation sulfonylureas differ from the first generation in structure and potency (1). The aliphatic side-chains of tolbutamide...References1. SKILLMANFELDMAN TJ. The pharmacology of sulfonylureas. Am J Med. 1981;70:361-72. CrossrefMedlineGoogle Scholar2. MELANDERWAHLEN-BOLL AE. Clinical pharmacology of glipizide. Am J Med. 1983;75(5B):41-5. CrossrefMedlineGoogle Scholar3. LEBOVITZFEINGLOS HM. Mechanism of action of the second generation sulfonylurea glipizide. Am J Med. 1983;75(5B):46-54. CrossrefMedlineGoogle Scholar4. PRINCEOLEFSKY MJ. Direct in-vitro effect of a sulfonylurea to increase human fibroblast insulin receptors. J Clin Invest. 1980;66:608-11. CrossrefMedlineGoogle Scholar5. MALOFFLOCKWOOD BD. In-vitro effects of a sulfonylurea on insulin action in adipocytes: potentiation of insulin-stimulated hexose trans port. J Clin Invest. 1981;68:85-90. CrossrefMedlineGoogle Scholar6. BROWNCROOKS KM. Displacement of tolbutamide, glibenclamide and chlorpropamide from serum albumin by anionic drugs. Biochem Pharmacol. 1976;25:1175-8. CrossrefMedlineGoogle Scholar7. ASPLUNDWIHOLMLITHNER KBF. Glibenclamide-associated hypoglycemia: a report on 57 cases. Diabetologia. 1983;24:412-7. CrossrefMedlineGoogle Scholar8. SHUMAN C. Glipizide: an overview. Am J Med. 1983;75(5B):55-9. CrossrefMedlineGoogle Scholar9. FEINGLOSLEBOVITZ MH. Long-term safety and efficacy of glipizide. Am J Med. 1983;75(5B):60-6. CrossrefMedlineGoogle Scholar10. WARDLANGPHILLIPSTURNER EDMR. Comparison of chlorpropamide and glibenclamide treatment of maturity-onset diabetes: control assessed by fasting plasma glucose concentrations. Diabetes Care. 1981;4:293-5. CrossrefMedlineGoogle Scholar11. CLARKE B. Comparative effectiveness of glyburide in the treatment of non-insulin-dependent diabetes. Postgrad Med. 1982;57-65. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT A. KREISBERG, M.D.Affiliations: University of South Alabama Medical Center Mobile, Alabama PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulfonylurea, an UpdateProgress in the discovery of naturally occurring anti-diabetic drugs and in the identification of their molecular targetsEfficacy and risk profile of anti-diabetic therapies: Conventional vs traditional drugs—A mechanistic revisit to understand their mode of actionHistory of current non-insulin medications for diabetes mellitusOral Hypoglycemic AgentsOral Hypoglycemic AgentsManagement of Noninsulin-dependent Diabetes MellitusThe pharmacology of oral agents used to treat diabetes mellitusThe Endocrine and Metabolic SystemsChlorpropamide and an Antabuse-like ReactionSUSAN D. WOLFSTHAL, M.D., THOMAS H. WISER, Pharm.D. 1 January 1985Volume 102, Issue 1Page: 125-126KeywordsFood and Drug AdministrationPatientsType 2 diabetes ePublished: 1 December 2008 Issue Published: 1 January 1985 PDF downloadLoading ...