tbuckley/cabot-search huggingface dataset:
Sense of smell in allergic and nonallergic rhinitis
Authors: M. Simola, H. Malmberg
Journal: Allergy (1998)

Hyposmia is a fairly common complaint in patients with long‐continuing aliergic or nonallergic rhinitis. Other factors such as aging, smoking, or nasal surgery may affect olfaction, but these have been little studied in rhinitisrelated hyposmia. The purpose of this study was to measure and compare olfactory thresholds in 105 rhinitis patients and 104 healthy controls and to analyze possible relationships between the sense of smell and rhinitis, age, sex, smoking, prick‐test results, nasal resistance, and history of nasal or paranasal surgery. The olfactory threshold was assessed with a commercially available kit of squeeze‐bottle pairs. The most important variables associated with the sense of smell were determined with stepwise multiple regression analysis, and intergroup differences were assessed with analysis of variance. The reference interval of olfactory thresholds by age was estimated with regression analysis. Nasal resistance was measured by active anterior rhinomanometry. Age and rhinitis were the only variables with significant effect on the olfactory threshold in the whole series. Both the proportion of hyposmic persons and the degree of the impairment of the sense of smell were significantly higher in the rhinitis group than in the control group. The nonallergic patients' sense of smell was poorer than that of seasonal or perennial allergic rhinitis patients. A history of operations for nasal polyposis was associated with hyposmia, but operations for chronic maxillary sinusitis were not. Neither smoking habits nor sex were related to olfactory thresholds. In conclusion, hyposmia in rhinitis patients is partly attributable to age‐related changes, but our results indicate that the disease itself impairs the sense of smell.
The Appropriateness of Coronary Procedures in Sweden
Authors: Steven J. Bernstein
Journal: JAMA (1994)

<h3>To the Editor.</h3> —We were most interested in the recent article by Ms Bengtson and colleagues<sup>1</sup>that reported that about 90% of coronary angiographies and coronary artery bypass graft (CABG) surgeries performed in southwestern Sweden were judged appropriate and about 2% inappropriate. They concluded that "the percentage of these patients [ie, referred for inappropriate or uncertain indications] is similar to the percentage recently reported from New York State." A review of the methods used, however, raises several additional questions. First, although their appropriateness criteria are well described, the method by which these criteria were established is not addressed. Are these criteria applicable and generalizable within Sweden? Comparing their criteria with those established by a multispecialty national Swedish expert panel<sup>2</sup>shows their criteria to be, in general, more liberal (ie, judging more cases to be appropriate). Without knowing the specific clinical details for each case, it is difficult to
Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells
Authors: Massimo Vitale, Jacques Zimmer, Roberta Castriconi, Daniel Hanau, Lionel Donato, Cristina Bottino, Lorenzo Moretta, Henri de la Salle, Alessandro Moretta
Journal: Blood (2002)
Gsα, protein kinase C, cathepsin D, growth factors, estrogen receptor-related protein, and p53 in prolactin cell adenomas and null cell adenomas of the pituitary
Authors: Lars Wellhausen, Wolfgang Saeger, Wolf Müller, Michael Derwahl, Christiane Hamacher, Dieter K. Lüdecke
Journal: Endocrine Pathology (1998)
Large single daily dose of histamine H2 receptor antagonist for duodenal ulcer. How much and when? A clinical pharmacological study.
Authors: M Deakin, H P Glenny, J K Ramage, J G Mills, W L Burland, J G Williams
Journal: Gut (1987)

The effects of single doses of cimetidine 800, 1200, and 1600 mg, given at 2300 h or 800, and 1600 mg at 1800 h, have been studied in patients with duodenal ulcer disease in symptomatic remission, and compared with cimetidine 400 mg bd (0800 h and 2300 h) and ranitidine 300 mg (given at 1800 h) respectively. A dose related reduction in intragastric acidity was seen. All single nocturnal (2300 h) doses of cimetidine produced anacidity overnight. This was not achieved with dosing at 1800 h although the duration of inhibition of gastric acidity was longer. Inhibition of overnight acid and pepsin outputs were similarly dose and timing related, but inhibition of peptic activity was much less after dosing at 1800 h. Cimetidine 1600 mg and ranitidine 300 mg were similar in their effects.
INCREASED MORTALITY IN ACUTE AORTIC DISSECTION PATIENTS WITH LOW ADHERENCE TO GUIDELINE RECOMMENDATIONS FOR IMAGING AND CLINIC FOLLOW-UP
Authors: Ashish Chaddha, Kim Eagle, Himanshu Patel, G. Michael Deeb, Kevin Harris, Alan Braverman, Stuart Hutchison, Arturo Evangelista, Rossella Fattori, James Froehlich, Christoph Nienaber, Eric Isselbacher, Daniel Montgomery, Eva Kline-Rogers, Elise Woznicki, Troy LaBounty
Journal: Journal of the American College of Cardiology (2014)
PREVENTIVE MEDICINE AND THE FUTURE OF MEDICAL PRACTICE
Authors: HENRY F. HELMHOLZ
Journal: JAMA (1924)

In no sphere of medicine does prevention play so large a part as in pediatrics, and in no other branch of medicine has the growth of a specialty been so intimately associated with a corresponding development of preventive measures, emphasis being placed on the prevention of disease rather than on its cure. I doubt whether any specialized field has ever grown more rapidly than pediatrics in the last fifteen years, and this at a time when preventive measures, so-called public health work, were being carried on very much more actively and extensively than ever before. One might almost say that the demand for the pediatrician was created by the campaign of education in health matters of childhood. At that time, the greatest field of preventive medicine, the first year of life, was almost entirely neglected. The general practitioner was content to leave the care and feeding of the infant to
A Health Questionnaire Based on Paper-and-Pencil Medium, Individualized and Produced by Computer
Authors: John G. Mayne, Maurice J. Martin, William F. Taylor, Peter C. O'brien, Patricia J. Fleming
Journal: Annals of Internal Medicine (1972)

This study tested the usefulness and acceptability to physicians of the medical history acquired by the first level of the mark-sense format patient-inventory questionnaire. The data, although accurate, were not useful for determining urgency of the medical problem, functional versus organic nature of the problem, complexity of the problem, physician time needed for consultation, the appropriate medical specialist to deal most efficiently with the problem, or specific laboratory tests needed to clarify diagnosis. Clinicians initially were enthusiastic about the technique but, after months of use, complained that it accumulated too much trivial information, necessitating increased physician time and work, and that the data were not helpful in making medical decisions. Questionnaire content must be based on the proposed use of the data if these data are to be useful; some technique such as higher-level questionnaires will be necessary to eliminate trivial information if the questionnaire is to be acceptable to physicians.
Climate change could overwhelm relief agencies, experts warn
Authors: P. Moszynski
Journal: BMJ (2009)

Global warming is likely to lead to a huge increase in the number and scale of humanitarian emergencies worldwide, senior officials from the United Nations and Red Cross warned last week.

Speaking at a special UK parliamentary meeting on the humanitarian implications of climate change, the UN’s emergency relief coordinator, John Holmes, said that international abilities to respond could well be overwhelmed unless immediate efforts towards reducing the risk of disaster are undertaken.

The International Federation of Red Cross and Red Crescent Societies said that climate change could bring “an increase in extreme weather events: more droughts, …
Phase II Trial of Neoadjuvant Bevacizumab Plus Chemotherapy and Adjuvant Bevacizumab in Patients with Resectable Nonsquamous Non–Small-Cell Lung Cancers
Authors: Jamie E. Chaft, Valerie Rusch, Michelle S. Ginsberg, Paul K. Paik, David J. Finley, Mark G. Kris, Katharine A.R. Price, Christopher G. Azzoli, Matthew G. Fury, Gregory J. Riely, Lee M. Krug, Robert J. Downey, Manjit S. Bains, Camelia S. Sima, Nabil Rizk, William D. Travis, Naiyer A. Rizvi
Journal: Journal of Thoracic Oncology (2013)
Osteonecrosis of the jaw and bisphosphonates
Authors: Eugene R Waclawski
Journal: BMJ (2006)

How doctors' anonymity in family courts is under threat Gornall is way out of dateEditor-Gornall is embarrassingly out of date in his detailed analysis of the B case (which was dealt with by the family courts nearly three years ago), and its relevance to proposed changes in the law to make the English family court system more transparent. 1 Since then, notwithstanding the ever increasingly exaggerated claims from some quarters that opening the family courts would harm children and deter court experts, the courts themselves are acknowledging the need for English family courts to do their business in the more transparent way that courts in Canada, Australia, and of course Scotland have done without apparent difficulty for years.Several High Court judgments have recorded judicial support for more openness to increase public confidence, and Gornall fails to mention that the president and many of his senior judges are in favour of change in this direction.In a landmark case which was decided on 3 November, Munby J agreed that an ongoing case where parents dispute expert evidence that they injured their child should be open to the media.The local authority concerned issued a "position statement" to the press and the reporting in the Times, Guardian, and the Mail on Sunday set out both sides' cases, as did the broadcasting media.A BBC "Real Story" programme on the case allowed a senior official from the local authority ample time to put their case.No vilification of any experts involved was reported.It is likely that more judges will follow Munby J's example and more public interest cases will be opened to the media pending any change in the law.Will the skies fall in?I doubt it, but your readers can judge for themselves.Hopefully they will understand that in complex childcare cases where expert evidence may be tenuous and the stakes for children are very high, public debate can stimulate awareness of the problems faced by all professionals involved in child protection.It's difficult getting the balance right, but doing it in secret doesn't help.
TCT-102 Efficacy and Safety of Balloon Pulmonary Angioplasty for Non-operable Chronic Thromboembolic Pulmonary Hypertension in Comparison to Pulmonary Endarterectomy for Operable Patients
Authors: Yu Taniguchi, Noriaki Emoto, Hiroto Kinutani, Hiromasa Otake, Toshiro Shinke, Ken-ichi Hirata
Journal: Journal of the American College of Cardiology (2013)
Intestinal Obstruction Due to Food
Authors: N. Ward-McQuaid
Journal: BMJ (1950)

Intestinal obstruction due to impacted foodstuffs is a rare but interesting and well-recognized surgical emergency. The incidence of this type of obstruction may be assessed from the analysis by Storck, Rothschild, and Ochsner (1940) of a series of 875 cases of acute intestinal obstruction, excluding those due to herniae, neoplasms, or peritonitis, and treated at the Charity Hospital, New Orleans. Of these, 51 were due to foreign bodies, and of this number five were caused by the impaction of food boluses. Handfield-Jones and Porritt (1948) give the incidence of intraluminal foreign body obstruction as 0.3% of all cases of acute intestinal obstruction. Latchmore (1940) had the exceptional experi ence of operating in one year on no fewer than four cases of obstruction due to food. There have been only four such cases at the Radcliffe Infirmary in the last 20 years. One of these was due to orange pith, and has been reported elsewhere by Fleming and Ward-McQuaid (1950). Elliot (1932) listed 40 cases of food impaction, and Fantus and Kopstein (1940) brought this number up to 75. Since their paper, single instances of small series have been reported. Four further cases are now recorded?two due to orange pith, one to almonds, and one to watercress? so that, including the other case due to orange pith men tioned above, 178 cases have now been traced. Delrio, Paz, and Carpanelli (1944) discussed 31 cases, including 7 of their own ; but 13 of these have not been included, as the case histories are not reviewed in full and the relevant original South American publications are not available. It is clear that great numbers of cases occur and are not reported, and perhaps the bizarre examples are more likely to be recorded than those that are less unusual.
Tweek, an Evolutionarily Conserved Protein, Is Required for Synaptic Vesicle Recycling
Authors: Patrik Verstreken, Tomoko Ohyama, Claire Haueter, Ron L.P. Habets, Yong Q. Lin, Laura E. Swan, Cindy V. Ly, Koen J.T. Venken, Pietro De Camilli, Hugo J. Bellen
Journal: Neuron (2009)
Smoking and bronchial responsiveness in nonatopic and atopic young adults. Spanish Group of the European Study of Asthma
Authors: J. Sunyer, J. M. Anto, M. Kogevinas, J. B. Soriano, A. Tobias, A. Munoz
Journal: Thorax (1997)

Smoking may influence the response of the lungs to other inhaled substances. A study was undertaken to assess the effect of the interaction between smoking and the immunoresponse to common aeroallergens (atopy) on bronchial responsiveness.A random sample was selected from the general population census of five areas of Spain (Albacete, Barcelona, Galdakao, Huelva, and Oviedo). A total of 1169 (35%) subjects completed a face-to-face respiratory questionnaire, a methacholine bronchial responsiveness challenge, and underwent measurements of total and specific serum IgE levels to mites, pets and moulds. A survival model (Weibull) was used to examine the methacholine dose-response relation, adjusting for bronchial obstruction.Smokers showed greater bronchial responsiveness than never smokers (p < 0.05) at any dose of methacholine, but only among non-atopic individuals. Atopy had a large effect on responsiveness at low levels of methacholine, but smoking did not increase responsiveness in atopic subjects. There were no differences in intensity or cessation of smoking between atopic and non-atopic subjects, suggesting that smoking self-selection does not fully explain these results.The association between smoking and bronchial responsiveness varies with atopy, which may be explained by different immunological and/or inflammatory effects of smoking on atopy.
A Case of Angina Pectoris Treated by Erythrol Tetranitrate, with Marked Benefit
Authors: J. B. Bradbury
Journal: BMJ (1897)

ERYTHROL TETRANITRATE IN ANGINA.[METHABLOUNAL 907 6. Gout is probably always preceded by some affection of the kidneys, functional or organic, which interferes with the proper excretion of uric acid.The probablp seat of the kidney affection giving rise to gout is in the epithelium of the coI- voluted tubes.7. In certain blood diseases and disorders accompanied by leucoeytosis uric acid is formed within the system from nuclein.Under such circumstances it passes at once into the blood and is rapidly eliminated by the kidneys.8. The solubility of uric acid in the blond is not affected by a diminished alkalinity of the blood produced by the addition of organic acids.9.The deposition of sodium biurate is not accelerated by a diminution of the alkalinity of the blood.IO.An increased alkalinity of the blood does not increase the solubility of deposits of sodium hiurate.i i.The saline constituents of vegetables exercise a remarkable inhibitory power over the decomposition of sodium quadriurate.12. The solubility of sodium biurate in the blood is increased by the presence of the saline constituents of veget- ables.13.The solubility of sodium biurate in the blood is diminished by the presence of the saline constituents of meat.14.The gout-inducing properties of certain wines are not due to their acidity.Probably they owe their gout-inducing action to the effect they exercise on the metabolism of the liver.
Two considerations for patients with psoriasis and their clinicians:
Authors: Gerald G. Krueger, Steven R. Feldman, Charles Camisa, Madeleine Duvic, James T. Elder, Alice B. Gottlieb, John Koo, James G. Krueger, Mark Lebwohl, Nicholas Lowe, Alan Menter, Warwick L. Morison, Janet H. Prystowsky, Jerome L. Shupack, J.Richard Taylor, Gerald D. Weinstein, Thomas L. Barton, Tara Rolstadr, Robert M. Day
Journal: Journal of the American Academy of Dermatology (2000)
Frederick Parkes Weber—1863-1962
Authors: Victor A. McKusick
Journal: JAMA (1963)

F PARKES WEBER (Figs 1 and 2) died on June 2 in his 100th year.<sup>1</sup>He distinguished himself in medicine as a keen observer and as an eagerly curious and tireless student of disease, particularly the unusual. Few others, if any, have given their name to so many diseases. The three best known of the Weber eponyms are: (1) Osler-Rendu-Weber's hereditary hemorrhagic telangiectasia<sup>2</sup>; (2) Sturge-Weber disease<sup>3</sup>—hemangiectatic nevus of the face and cerebral meninges; and (3) Weber-Christian disease<sup>4</sup>—relapsing febrile nodular nonsuppurative panniculitis. But others are the Weber-Klippel syndrome<sup>5-7</sup>— hemangiectatic hypertrophy of the limbs (see Fig 3 for an example); Vaquez-Osler-Weber disease<sup>8,9</sup>—polycythemia vera with splenomegaly; Weber-Cockayne familial recurrent bullous eruption of the hands and feet,<sup>10</sup>which is a form of localized epidermolysis bullosa.<sup>11,12</sup> Weber's voluminous writings, numbering over 1,200, began in 1890 with a paper "on abnormal foramina in the
TRAUMA AND DEMENTIA PARALYTICA
Authors: JOSEPH V. KLAUDER
Journal: JAMA (1931)

Severe injury of the head in relation to the development of dementia paralytica is of considerable medicolegal importance. This relation is constantly being discussed in courts of law and before industrial accident boards. In 1822 when Bayle first isolated dementia paralytica as an organic brain disease, trauma was mentioned as a cause. Since that time the rôle of trauma in the production of dementia paralytica runs like a red streak through the history of the disease. The problem of the relation between head trauma and dementia paralytica may be stated as follows: Granted that dementia paralytica is a syphilitic disease of the brain, what rôle does an injury to the head play in the production of initial symptoms of the disease appearing subsequent to such injury and how long delayed may such symptoms be in order to be ascribed to the trauma? What is the rôle of trauma when symptoms
Colposcopic assessment of the accuracy of cervical cytology screening
Authors: J. A Giles, E. Hudson, J. Crow, D. Williams, P. Walker
Journal: BMJ (1988)

Two hundred asymptomatic women in a general practice were screened both cytologically and colposcopically for evidence of cervical intraepithelial neoplasia. The prevalence detected by cytology alone was 5%, but the prevalence detected by cytology and colposcopy together was 11%. None of the larger lesions of cervical intraepithelial neoplasia (affecting more than two quadrants of the cervix) was associated with negative cytology. The false negative cytology rate for smaller lesions was 58%. The clinical importance of the smaller lesions that were not accurately detected by cytology screening is unknown. As these lesions affected 6% of the screened population further studies of their clinical course are urgently required. Local destructive treatment in such cases may represent considerable overtreatment. If these lesions prove to be clinically important, however, the results of this study predict an increasing epidemic of preinvasive and invasive disease of the cervix.
A COMBINED VISUAL AND ASTIGMATIC TEST-CARD OF WORDS MADE UP OF LETTERS CONFUSING TO THE ASTIGMATIC EYE---REMARKS ON ASTIGMATISM, CHARACTERISTIC MANNERISMS.
Authors: WILLIAM S. LITTLE
Journal: JAMA (1884)

Read in Section on Ophthalmology, Otology and Laryngology of the American Medical Association, May, 1884, The influences of optical defects are three-fold; first, productive of vision less than normal; second, are productive of certain ocular diseases or render acute attacks of eye disease chronic by their presence; third, there are produced by their presence, headache, nervous symptoms, gastric disturbance, many cases of so-called biliousness and a chain of reflex symptoms due to the accommodative effort. Cases presenting a manifest defect of vision, seek relief by glasses, and are satisfied either partially or fully, as the manifest or total defect is corrected. In cases where ocular disease, or the form of trouble described under the third classification exists, accommodative effort may conceal the defect, which any of the mydriatics will expose and relieve the symptoms if they are the result of the optical condition of the eye; glasses are required to
IMPLICATIONS OF THE DISCREPANCY IN EJECTION FRACTION REPORTING BETWEEN ECHOCARDIOGRAPHY AND RADIONUCLIDE ANGIOGRAPHY IN A TERTIARY CARE HEART FUNCTION CLINIC
Authors: Katrina Elise Zefkic, Michael Chiu, Ian Burwash, Haissam Haddad, Ross Davies, Ellamae Stadnick, Peter Liu, Rob Beanlands, Terrence Ruddy, Lisa Mielniczuk
Journal: Journal of the American College of Cardiology (2014)
Patterns of Infectious Drug Resistance in a General Hospital.
Authors: Antone A. Medeiros
Journal: Annals of Internal Medicine (1967)

s1 May 1967Patterns of Infectious Drug Resistance in a General Hospital.Antone A. Medeiros, M.D., Thomas F. O'Brien, M.D.Antone A. Medeiros, M.D.Search for more papers by this author, Thomas F. O'Brien, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1047_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor many years every antibiotic-resistant bacterium was presumed to be a spontaneous mutant or the direct descendant of one. Recently, bacteria have been shown to be capable of transferring multiple antibiotic resistance to other bacteria, even bacteria of other species. This occurs during cell-to-cell contact by the direct transmission of cytoplasmic genetic determinants of antibiotic resistance called R factors. For the past year we have been investigating the significance of this phenomenon in a general hospital both by a continuing computer analysis of all antibiotic-resistance tests performed by the clinical microbiology laboratory and by experimental transfer of drug resistance.Computer... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInfectious diseases. Annual review of significant publications. 1 May 1967Volume 66, Issue 5Page: 1047-1047KeywordsAntibiotic resistanceBacteriaClinical microbiologyComputersDrugsGenetic determinismResearch laboratories Issue Published: 1 May 1967 PDF DownloadLoading ...