Intravenous Trimethoprim-Sulfamethoxazole and Ataxia
Authors: LEO X. LIU
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 March 1986Intravenous Trimethoprim-Sulfamethoxazole and AtaxiaLEO X. LIU, M.D., SUSAN J. SEWARD, M.D., CLYDE S. CRUMPACKER, M.D.LEO X. LIU, M.D.Search for more papers by this author, SUSAN J. SEWARD, M.D.Search for more papers by this author, CLYDE S. CRUMPACKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-448_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Many adverse reactions have been reported recently (1-3) to intravenous trimethoprim-sulfamethoxazole, a combination widely used in the therapy for Pneumocystis carinii pneumonia. We report two cases of severe reversible ataxia that developed in patients during such therapy.Patient 1: A 47-year-old homosexual man with known diffuse lymphadenopathy was admitted with fever, hypoxia, and diffuse interstitial lung infiltrates. The neurologic findings on admission were normal. A bronchoscopic biopsy sample showedP. cariniipneumonia, and treatment with intravenous trimethoprim-sulfamethoxazole, 20 mg/kg · d was begun. The patient developed unsteadiness and falling by day 3 of therapy. Neurologic examination now...References1. JICK H. Adverse reactions to trimethoprim-sulfamethoxazole in hospitalized patients. Rev Infect Dis. 1982;4:426-8. CrossrefMedlineGoogle Scholar2. . Assessment of therapy for Pneumocystis carinii pneumonia. Am J Med. 1984;76:501-8. CrossrefMedlineGoogle Scholar3. GORDIN F, SIMON G, WOFSY C, and MILLS J. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1984;100:495-9. LinkGoogle Scholar4. SIBER G, GORHAM C, ERICSON J, and SMITH A. Pharmacokinetics of intravenous trimethoprim-sulfamethoxazole in children and adults with normal and impaired renal function. Rev Infect Dis. 1982;4:566-78. CrossrefMedlineGoogle Scholar5. SNIDER W, SIMPSON D, NIELSON S, GOLD J, METROKA C, and POSNER J. Neurologic complications of the acquired immune deficiency syndrome: analysis of fifty patients. Ann Neurol. 1983;14:403-17. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LEO X. LIU, M.D.; SUSAN J. SEWARD, M.D.; CLYDE S. CRUMPACKER, M.D.Affiliations: Beth Israel Hospital Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulfonamidesTrimethoprim and co-trimoxazoleTetrahydrobiopterin Biosynthesis as an Off-Target of Sulfa DrugsANTIBACTERIAL DRUGSMemantine-Induced Myoclonus and Delirium Exacerbated by TrimethoprimSulfonamidesTrimethoprim and co-trimoxazoleAdverse Reactions to Trimethoprim/Sulfamethoxazole in AIDSAcute delirium induced by intravenous trimethoprim–sulfamethoxazole therapy in a patient with the Acquired Immunodeficiency SyndromeTrimethoprim-Sulfamethoxazole-Induced Tremor in an Immunocompetent PatientTrimethoprim/Sulfamethoxazole-Induced Tremor in a Patient with AIDSTremor Induced by Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome (AIDS)Michael J. Borucki, MD, Debbie S. Matzke, MD, Richard B. Pollard, MDMiscellaneous antibacterial and antiviral drugs 1 March 1986Volume 104, Issue 3Page: 448-448KeywordsAdverse reactionsAtaxiaBiopsyFeversHomosexualsHypoxiaLungsPneumocystis carinii pneumoniaPneumonia ePublished: 1 December 2008 Issue Published: 1 March 1986 PDF downloadLoading ...