tbuckley/cabot-search huggingface dataset:
1103-165 Serum levels of angiogenic growth factors predict long-term clinical outcome after percutaneous coronary revascularization
Authors: Karine Sautiere, Sophie Susen, Francois Cuilleret, Akram Chmait, Arnaud Sudre, Frederic Mouquet, Jean Dallongeville, Christophe Bauters, Jean Marc Lablanche, Brigitte Jude, Eric Van Belle
Journal: Journal of the American College of Cardiology (2004)
Carcinoembryonic antigen in breast-cancer tissue: a useful prognostic indicator.
Authors: S Shousha, T Lyssiotis, V M Godfrey, P J Scheuer
Journal: BMJ (1979)

Sections of breast carcinomas removed from 69 patients six to 13 years previously were examined using an immunoperoxidase technique to determine whether carcinoembryonic antigen (CEA) was present. Patients who had CEA-negative tumours had significantly higher five- and 10-year survival rates. The difference was not related to the stage of the disease, postoperative treatment, or histological type of tumour. These results suggest that immunohistological assessment of CEA in breast-cancer tissue may provide more precise prognostic information.
Trimethioprim-Sulfamethoxazole-Reply
Authors: Donald O. Schiffman
Journal: JAMA (1975)

<h3>In Reply.—</h3> The sentence to which Dr. Goloff refers was intended to convey the meaning that the combination of trimethoprim and sulfamethoxazole is an effective and therefore primary medication for treating certain urinary tract infections. It was not meant to imply that this mixture is the best possible anti-infective for treating urinary tract infections or that it is necessarily a drug of choice for such purposes. It is important for every physician to have some general concept of the cost of each prescription he writes, especially if his patient possesses limited financial means. Certainly there are several good, less expensive regimens for treating urinary tract infections than the trimethoprim-sulfamethoxazole mixture. Nevertheless, if special conditions arise to indicate that this combination may be the drug of choice or if a strain of microorganism refractory to other conventional forms of medication is found to be sensitive to this mixture, the cost of
Cdk5-dependent regulation of glucose-stimulated insulin secretion
Authors: Fan-Yan Wei, Kazuaki Nagashima, Toshio Ohshima, Yasunori Saheki, Yun-Fei Lu, Masayuki Matsushita, Yuichiro Yamada, Katsuhiko Mikoshiba, Yutaka Seino, Hideki Matsui, Kazuhito Tomizawa
Journal: Nature Medicine (2005)
Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution.
Authors: F S di Giovine, S E Malawista, E Thornton, G W Duff
Journal: Journal of Clinical Investigation (1991)

Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Biologically active cell-associated TNF activity peaked at 3 h and was exceeded at 6 h by extracellular activity, which peaked at 12-18 h. Comparable kinetics were observed with immunoreactive TNF alpha. TNF alpha mRNA accumulation in monocytes stimulated with MSU crystals appeared as a single peak at 2-4 h, kinetics compatible with rapid production of a short half-life transcript. In contrast, crystals of calcium pyrophosphate or of hydroxyapatite did not stimulate significant production of TNF or of message. Fresh tophaceous material from a patient with gout contained significant levels of TNF alpha and cells cultured from the tophus produced TNF alpha in vitro. In rheumatoid synovial cells, spontaneous release of TNF alpha was increased by in vitro exposure to MSU crystals. Taken together with earlier work, these results support an expanded view of gouty inflammation in which the crystal-stimulated production of cytokines provides a crucial link between crystal deposition and many of the clinical and pathological facts of both acute and chronic gouty arthritis.
Cyclooxygenase-2 Is Required for Tumor Necrosis Factor-α– and Angiotensin II–Mediated Proliferation of Vascular Smooth Muscle Cells
Authors: Wilson Young, Keyvan Mahboubi, Asifa Haider, Irene Li, Nicholas R. Ferreri
Journal: Circulation Research (2000)

Abstract —Tumor necrosis factor-α (TNF-α) and angiotensin II (Ang II) induced a transient increase in vascular smooth muscle cell (VSMC) cyclooxygenase-2 (COX-2) mRNA accumulation, without affecting COX-1 mRNA levels. The kinetics of COX-2 mRNA accumulation were similar in VSMCs challenged with either TNF-α or Ang II; mRNA accumulation peaked at 2 hours and decreased to control levels by ≈6 hours. Accumulation of COX-2 mRNA was associated with a time-dependent increase of COX-2 protein expression that displayed similar kinetics in response to either TNF-α or Ang II. Both the increase in COX-2 mRNA accumulation and protein expression in response to either TNF-α or Ang II were inhibited by the mitogen-activated protein/extracellular signal–regulated kinase (MEK) inhibitor PD098059. In addition, the AT 1 -selective receptor antagonist losartan attenuated the Ang II–mediated increase in COX-2 mRNA accumulation; the AT 2 -selective antagonist PD123319 had no effect. Prostacyclin I 2 synthesis was tightly coupled to expression of COX-2, whereas prostaglandin E 2 and thromboxane A 2 (TXA 2 ) synthesis may be associated with differential usage of COX-1 and COX-2. The COX-2–selective inhibitors NS-398 and nimesulide and the TXA 2 receptor antagonist BMS 180,291 inhibited TNF-α– and Ang II–mediated increases in DNA content and cell number by ≈95%. These findings suggest that a prostanoid derived from COX-2, possibly TXA 2 , may contribute to VSMC hyperplasia in vessel injury or pathophysiological conditions associated with elevated levels of either TNF-α or Ang II.
Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia
Authors: Manjula Karpurapu, Xuerong Wang, Jing Deng, Hyesuk Park, Lei Xiao, Ruxana T. Sadikot, Randall S. Frey, Ulrich A. Maus, Gye Young Park, Edward W. Scott, John W. Christman
Journal: Blood (2011)
Towards characterization of epidermal cell migration promotion activity in serum
Authors: E. MITRANI, R. MARKS
Journal: British Journal of Dermatology (1978)

The effect of various fractions of serum on active epidermal cell migration in vitro has been studied by incubating small explants of normal human skin in the presence of the fractions and determining the extent of migration after 48 h incubation. Serum was fractionated by combining ammonium sulphate precipitation and molecular sieve chromatography using Sephadex G-200. The components of serum responsible for most, if not all, of the migration promotion activity were localized in the G-200 third peak (albumin fraction) of the supernatant after precipitation of the serum with ammonium sulphate at 50% saturation.
[647] SEQUENCE VARIATION OF NS3/4A IN HCV REPLICONS EXPOSED TO ITMN-191 CONCENTRATIONS ENCOMPASSING THOSE LIKELY TO BE ACHIEVED FOLLOWING CLINICAL DOSING
Authors: S.D. Seiwert, J. Hon, S.R. Lim, T. Wang, H. Tan, L.M. Blatt
Journal: Journal of Hepatology (2007)
When Opioids Cause Pain
Authors: Mellar P. Davis, Lauren A. Shaiova, Martin S. Angst
Journal: Journal of Clinical Oncology (2007)

A 54-year-old African American man with an 8-month history of hepatocellular carcinoma causing spinal cord compression and status, postradiation therapy of the spine, suffered from back pain accompanied by burning and lancinating pain in both thighs. Pain therapy consisted of oral oxycodone extended release 800 mg every 8 hours and rescue doses of oral oxycodone 200 mg every 1 hour as needed for breakthrough pain. Additional medications included dexamethasone 6 mg every 6 hours, pregabalin 150 mg every 8 hours, and levetiracetam 1,500 mg every 12 hours. Three weeks after completing radiation therapy, the patient complained of increasing, generalized burning pain and an exquisite sensitivity to light touch or any type of clothing in contact with his body. The pain was generalized but most prominent in the lower extremities. The patient rated the pain intensity as a 10/10 on a numerical rating scale (NRS; 0 no pain, 10 worst pain imaginable). Changing the patient’s pain therapy to oral methadone 225 mg every 8 hours and buccal fentanyl 800 g every 1 hour as needed provided some shortterm relief of the burning sensation but the allodynia persisted. Five days later, the patient’s burning pain was back to a 10/10 on a NRS and was accompanied by severe touch-evoked allodynia and myocloni of the lower and upper extremities. The patient was unable to perform daily activities. Turning him in bed or putting blankets on him provoked intolerable pain. Changing the patient’s pain therapy to intravenous methadone 30 mg/h with intravenous methadone 10 mg every 15 minutes as needed for breakthrough pain provided some short-term relief. However, within 2 days the patient suffered again from generalized severe burning pain (10/10 NRS), allodynia, and myocloni while also becoming delirious. A positron emission tomography scan and magnetic resonance imaging of the total spine demonstrated no major structural change, and an magnetic resonance imaging scan of the head revealed no brain metastases or other intracranial pathology. Intravenous lorazepam 1 mg as needed and intravenous ketamine 1 mg/h were started to alleviate symptoms. Over the course of 1 week, ketamine was increased to 13 mg/h with partial resolution of the myocloni but persistence of the delirious state. Subsequently, intravenous methadone was reduced over 4 to 5 days to 12 mg/h. This resulted in decreased burning pain (5 to 6 of 10 NRS) and reduced allodynia. An attempt to increase the methadone dose aggravated the burning pain as well as the allodynia. The patient was kept on intravenous methadone 12 mg/h, ketamine 13 mg/h, and lorazepam 1 to 2 mg as needed. He died 3 months later on home hospice. His pain remained at 4 to 5 of 10 (NRS) for the last month of his life with neuropathic pain, but less intense allodynia and myocloni-free intervals were of longer duration. His mental status waxed and waned until he died.
Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins
Authors: Lu Wang, Rachael A. Gordon, Linda Huynh, Xiaodi Su, Kyung-Hyun Park Min, Jiahuai Han, J. Simon Arthur, George D. Kalliolias, Lionel B. Ivashkiv
Journal: Immunity (2010)
Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy
Authors: Philip C. Christophersen, Ditlev Birch, Jukka Saarinen, Antti Isomäki, Hanne M. Nielsen, Mingshi Yang, Clare J. Strachan, Huiling Mu
Journal: Journal of Controlled Release (2014)
Analysing the Outcome and Prognostic Factors of Elderly Patients Treated with Single Agent Versus Combination Regimen as First-Line Chemotherapy for Recurrent or Metastatic Gastric Cancer
Authors: D.S. Sun, E.K. Jeon, Y.H. Ko, H.S. Won, B.Y. Shim, S.Y. Rho, H.K. Kim, S.Y. Park, S.Y. Hong
Journal: Annals of Oncology (2014)
Marginal analysis in practice
Authors: A. Mordue, N. Craig
Journal: BMJ (1994)

by advertisement in the media.2Smokers were categorised into three groups reflecting their previous attempts to stop smoking, and an identical antismoking intervention was applied to each.Smokers who had made more attempts in the past had a higher point prevalence of smoking cessation one and six months later.They also reported significantly higher numbers of attempts to stop.To increase our understanding of the process of stopping smoking, studies should include a measure of subjects' previous attempts to stop.If previous attempts to stop were found to be a consistent predictor of stopping, simple questions about previous attempts could be incorporated into clinical practice.These would indicate to general practitioners which smokers were most likely to respond to advice, facilitating the effective targeting of health promotion activity.
Secretory cells of the peripheral pulmonary epithelium as targets for toxic agents.
Authors: G E Hook, R P DiAugustine
Journal: Environmental Health Perspectives (1976)

The extracellular lining of the pulmonary peripheral airways is of vital importance to the lung. In this report, some aspects of the pulmonary extracellular lining and the epithelial cells believed to be responsible for its formation and secretion have been briefly reviewed. The influence of a number of toxic agents on the extracellular lining either directly or via those cells involved in its formation indicates that the extracellular lining may be important in understanding numerous toxic agent interactions with the lung.
THE PROBLEM OF THE SNELLEN SYMBOL
Authors: J. A. C. Gabriels
Journal: JAMA (1933)

<h3>To the Editor:</h3> —The report of the Committee on Compensation Tables for Eye Injuries (The Journal, July 22) indicates anew the lack of unanimity in appraising loss of visual efficiency, and likewise an apparent disinclination on the part of physicians and insurance carriers, as well as of the various industrial boards, to accept the method of evaluating the Snellen symbol approved by the committee. The crux of the problem is, of course, the correct interpretation of the value residing in the Snellen visual symbol. Numerous tables of values purporting to offer the solution of this phase of the subject have made their way into print at different times. In this connection it may be said that any method of determination which evolves from premises inexact by their nature cannot but lead, however ingeniously and mathematically, to an inaccurate, unsatisfactory conclusion. Investigation of this question, some years ago (Gabriels, J. A.
<i>The Trouble with Medical Journals</i> by Richard Smith: an alternative view
Authors: Pritpal S Tamber
Journal: BMJ (2007)

I am amazed that the BMJ has published such a negative review of a book that should be shaking medicine's foundations ( BMJ 2007;334:45). Medical publishing has many failings; the fact that this book is not compulsory reading for everyone may well be yet another. 

Although starting positively, reviewer Stuart Derbyshire describes Smith's concerns as not “obviously supportable.” Smith, together with colleagues at JAMA , has probably done more than anyone to search for “evidence” for the true value in the cornerstone of medical publishing: peer review. Much of the research conducted at the BMJ during his tenure showed that there is little or no objective value to the process,1 yet journals and their editors persist with—and advocate—peer review; their only defence is that “there's nothing better,” even though few have tried to find an alternative (to my mind there is a notable exception, the system used by Biology Direct2). 

Derbyshire also talks of the …
Induction of interleukin 12 responsiveness is impaired in anergic T lymphocytes.
Authors: H Quill, A Bhandoola, G Trinchieri, J Haluskey, D Peritt
Journal: The Journal of Experimental Medicine (1994)

The cytokine, interleukin 12 (IL-12), stimulates both natural killer cells and T cells to proliferate and to secrete interferon gamma (IFN-gamma). The T cell proliferative response to IL-12 must be induced and is evident after T cell receptor-mediated stimulation. As reported here, tolerant CD4+ T cells and clones, that are anergic for IL-2 production, are also anergic for induction of the proliferative response to IL-12. Murine T helper 1 clones tolerized in vitro, as well as anergic CD4+ T cells isolated from mice tolerized to the Mls-1a antigen (Ag) in vivo, demonstrated defective induction of proliferation to IL-12 upon restimulation with Ag. IL-12-enhanced production of IFN-gamma was observed in both control and anergic cells after Ag/antigen-presenting cell (APC) activation, although total IFN-gamma secretion by anergic cells was less than that produced by control cells, even in the presence of IL-12. These data indicate that T cell clonal anergy results in profound inhibition of proliferative responses, since the autocrine growth factor, IL-2, is not produced, and the APC-derived cytokine, IL-12, is not an effective stimulus for anergic T cell proliferation.
The Diverse Ethics of Translational Research
Authors: Neema Sofaer, Nir Eyal
Journal: The American Journal of Bioethics (2010)

Commentators on the ethics of translational research find it morally problematic. Types of translational research are said to involve questionable benefits, special risks, additional barriers to informed consent, and severe conflicts of interest. Translational research conducted on the global poor is thought to exploit them and increase international disparities. Some commentators support especially stringent ethical review. However, such concerns are grounded only in pre-approval translational research (now called T1). Whether or not T1 has these features, translational research beyond approval (T2: phase IV, health services, and implementation research) is unlikely to and, when conducted on the global poor, may support development. Therefore, insofar as T1 is morally problematic, and no independent objections to T2 exist, the ethics of translational research is diverse: while some translational research is problematic, some is not. Funding and oversight should reflect this diversity, and T2 should be encouraged, particularly when conducted among the global poor.
Temperature monitoring during radiofrequency catheter ablation of accessory pathways.
Authors: J J Langberg, H Calkins, R el-Atassi, M Borganelli, A Leon, S J Kalbfleisch, F Morady
Journal: Circulation (1992)

Animal studies have suggested that the temperature of the electrode-tissue interface during radiofrequency catheter ablation accurately predicts lesion size. The purpose of the current study was to evaluate the utility of continuous temperature monitoring during radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome.Twenty patients with manifest preexcitation were included in the study. The ablation catheter was positioned on the ventricular side of the mitral annulus for left-sided accessory pathways and on the atrial side of the tricuspid annulus for right-sided and septal accessory pathways. A thermistor imbedded in the distal electrode of the ablation catheter allowed continuous temperature monitoring during each energy application. To define the relation between power and temperature, radiofrequency current was applied several times at each site using outputs of 20, 30, 40, and 50 W. The accessory pathways were successfully ablated in each of the 20 patients. Because of marked variability in the efficiency of heating between sites, power output did not predict temperature. However, at any given site, there was a positive dose-response relation between power and temperature. Radiofrequency energy applications on the atrial side of the tricuspid annulus produced lower temperatures than did applications on the ventricular side of the mitral annulus (49 +/- 7 versus 60 +/- 16 degrees C, p = 0.0001). Transient block in the accessory pathways occurred at a mean of 50 +/- 8 degrees C, whereas permanent block was seen at a mean of 62 +/- 15 degrees C (p = 0.0001). Less than half of the applications at outputs < or = 40 W produced temperatures adequate to interrupt accessory pathway conduction. An abrupt rise in impedance caused by coagulum formation occurred only at temperatures between 95 and 100 degrees C.Temperature monitoring may facilitate radiofrequency catheter ablation of accessory pathways. By adjusting power output to ensure that adequate but not excessive temperatures have been achieved, a rise in impedance can be avoided and the total number of energy applications and procedure duration may be reduced.
K- - - -X-Rated Therapy:—Another View
Authors: RODNEY K. KUSUMI
Journal: Annals of Internal Medicine (1981)

Letters1 January 1981K- - - -X-Rated Therapy:—Another ViewRODNEY K. KUSUMI, M.D.RODNEY K. KUSUMI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-1-139_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: It started as an area of innocent, localized warmth and swelling and was definitely not like the pain of podagra that can wake you up at two in the morning. Several hours later it was worse, and I identified an area of cellulitis. With an infectious disease giant like Kunin as Chairman, what better illness could an Ohio State infectious disease fellow contract? Cellulitis is a simple, yet common infectious disease problem. Many of my associates had shown interest in it, even doing several drug studies in treating it, but who else had gone far enough to...Reference1. BITTNER M. K- - - -X-rated therapy. Ann Intern Med. 1980; 93:636. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ohio State University Columbus, OH 43210 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1981Volume 94, Issue 1Page: 139-139KeywordsCellulitisDrugsInfectious diseasesInflammation Issue Published: 1 January 1981 PDF downloadLoading ...
Dangers of Splenectomy
Authors: Anwer Ui Haque
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Juan F. Jaramillo, MD, and Leroy C. Barry, MD (243:1656, 1980), advocated repair for the traumatic spleen in agnogenic myeloid metaplasia because of the operative and some postoperative complications. However, they did not mention the real risk of grave and often fatal course of certain blood born infections, especially pneumococcemia, in patients who have undergone splenectomies. This risk apparently persists for the entire lifetime of the patients.<sup>1</sup>The preventive and prophylactic measures, such as immunization, autotransplantation, and long-term penicillin therapy, are under investigation, although these measures also have some inherent difficulties, such as patient compliance. It has been recently reported<sup>2</sup>that a patient who has undergone splenectomy and who discontinued prophylactic penicillin therapy for only two weeks died of pneumococcemia. Burrington<sup>3</sup>has reported successful repair of ruptured spleens in eight cases. In my opinion every spleen that has sustained traumatic injury deserves a serious
980-85 Percutaneous Aspiration Thrombectomy: A Novel Way to Recannalize Thrombosed Hemodialysis Access Grafts
Authors: Reynaldo Mulingtapang, Stephen Jenkins, Peter Wassmer, Sylvia Griffin, Jill Lindberg, Julio Figueroa, Christopher White, Tyrone Collins, Stephen Ramee
Journal: Journal of the American College of Cardiology (1995)