tbuckley/cabot-search huggingface dataset:
Cancer Chemotherapy and Cognitive Function in Rodent Models: Memory Impairment Induced by Cyclophosphamide in Mice
Authors: André B. Reiriz, Gustavo K. Reolon, Thales Preissler, Joemerson O. Rosado, João Antônio P. Henriques, Rafael Roesler, Gilberto Schwartsmann
Journal: Clinical Cancer Research (2006)

To the Editor: The study by Lee et al. ([1][1]) is the first report on the effects of cancer chemotherapy on cognitive function in rodent models. Given the increasing concern about cognitive dysfunction in patients receiving chemotherapy, the development of animal models to characterize chemotherapy
Three days needed to recover from head injuries
Authors: K. Abbasi
Journal: BMJ (1997)

Athletes who have sustained mild head injuries should not be allowed to play again until at least three days after the symptoms have disappeared a recent study suggests.

The researchers, from the University of North Carolina, claim that although healing after a head injury takes more than a week, the first few days are crucial in allowing athletes' balance to recover and prevent further injury ( Medicine and Science …
The Value of the Hyperlipidemias in Predicting Coronary Atherosclerosis in Patients Undergoing Coronary Arteriography.
Authors: Spencer B. King
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973The Value of the Hyperlipidemias in Predicting Coronary Atherosclerosis in Patients Undergoing Coronary Arteriography.Spencer B. King III, M.D., Fred W. Schoonmaker, M.D., Christie B. Hopkins, M.D.Spencer B. King III, M.D.Search for more papers by this author, Fred W. Schoonmaker, M.D.Search for more papers by this author, Christie B. Hopkins, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-820_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough a classic history of angina is the most sensitive predictor of coronary artery disease, the presence of hyperlipidemia is also being used to predict this disease. To establish the value of the Fredrickson types for predicting the presence of coronary artery disease in patients with chest pain syndromes, 947 consecutive patients undergoing coronary arteriography had postabsorptive serum cholesterol, triglyceride, and lipoprotein electrophoresis measurements to establish their presumptive lipoprotein classification. Patients were typed by criteria employed by the National Center for Disease Control as having type IIA, type IIB, type IV, or no lipid abnormality.There were 631 patients with... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 820-820KeywordsAnginaAngiographyCholesterolCoronary arteriesHyperlipidemiaIschemiaLipidsLipoproteinsStable coronary artery disease Issue Published: 1 May 1973 PDF downloadLoading ...
Prospective randomized trial for hormonal-targeted therapy in advanced hepatocellular carcinoma
Authors: A. Pulvirenti, E. Villa, A. Marchiano, T. Camerini, L. Mariani, E. Regalia, M. Schiavo, D. Sarli, R. Romito, S. Perrone, J. Coppa, V. Mazzaferro
Journal: Journal of Hepatology (2003)
Arterial embolization caused by injection of hyaluronic acid (Restylane)
Authors: N.J. Lowe
Journal: British Journal of Dermatology (2003)

Sir, the report of arterial embolism caused by one of the hyaluronic acid (Restylane) fillers1 is an important reminder that dermal fillers are not without a variety of safety concerns.2, 3 I have observed a vascular problem in the upper lip that resulted from a delayed Restylane reaction causing venous occlusion with a resulting varix and persistent tissue swelling that has lasted 6 years. The varix was confirmed by skin biopsy, there being no residual detectable hyaluronic acid using appropriate histopathological stains. In addition, the authors may be interested in our recently published paper on hyaluronic acid dermal filler reactions and skin testing.2 We have in this paper documented delayed reactions to Hylaform and Restylane in approximately 0·4% of 709 patients. They were seen between 1996 and 1999. It is to be noted that the reaction rate to Restylane has decreased since 1999 when the formulation was changed (Lowe NJ, manuscript in preparation).
Violence may be serious in men with body dysmorphic disorder
Authors: P. Lucas
Journal: BMJ (2002)

EDITOR—Phillip and Castle in their editorial on body dysmorphic disorder in men said that patients disappointed with ineffective surgical or dermatological treatment may become violent towards the treating physician.1 There are grounds for considering that violence may be a more serious problem in this disorder than hitherto recognised, especially in view of the associated use …
Expression of proliferation-associated proteins (proliferating cell nuclear antigen and Ki-67 antigen) in Bowen's disease
Authors: H.-P. BAUM, I. MEURER, G. UNTEREGGER
Journal: British Journal of Dermatology (2006)

Bowen's disease and invasive squamous cell carcinoma arising in Bowen's disease (Bowen's carcinoma) were investigated immunohistochemically with regard to their expression of proliferating cell nuclear antigen (PCNA) and the Ki‐67 antigen. Both proliferation‐associated proteins were found in all layers of the tumours, and were present in nuclei of any size and shape. The nucleoli lacked PCNA immunoreactivity, but they expressed the Ki‐67 antigen. The PCNA labelling index was 36.9±12.6% in Bowen's disease (n= 16), and 40.7±11.0% in Bowen's carcinoma (n=3). The Ki‐67 antigen labelling index was 43.6±16.7% in Bowen's disease (n=16), and 51.7±11.6% in Bowen's carcinoma (n=3). Dyskeratotic cells were positive for PCNA and the Ki‐67 antigen, suggesting that these cells are not in a post‐mitotic state. We conclude that in dyskeratotic cells of Bowen's disease the cell cycle is interrupted by nuclear disorganization.
Influence of anatomic correction for transposition of the great arteries on myocardial perfusion: Radionuclide imaging with technetium-99m 2-methoxy isobutyl isonitrile
Authors: Alison M. Hayes, Edward J. Baker, Ashok Kakadeker, Jonathan M. Parsons, Robin P. Martin, Rosemary Radley-Smith, Shakeel A. Qureshi, Magdi Yacoub, Michael N. Maisey, Michael Tynan
Journal: Journal of the American College of Cardiology (1994)
Polymers Fight HIV: Potent (Pro)Drugs Identified Through Parallel Automated Synthesis
Authors: Kaja Zuwala, Anton A. A. Smith, Almar Postma, Carlos Guerrero‐Sanchez, Pau Ruiz‐Sanchis, Jesper Melchjorsen, Martin Tolstrup, Alexander N. Zelikin
Journal: Advanced Healthcare Materials (2014)

Macromolecular (pro)drugs interfere with the proliferation of HIV through both inhibition of viral cell entry and via intracellular delivery of antiviral drugs. Lead polymer conjugates exhibit longevity of action exceeding that of parent nucleoside analogue drug and are active in primary T cell over at least 72 h. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Which Medicine, Which America?
Authors: Michael Fine
Journal: New England Journal of Medicine (2009)

Underlying the debate over health care reform are two competing visions of medicine. According to one vision, medicine aims to care for people in their communities and to provide affordable health care that counterbalances the effects that inequities of income and opportunity have on populations' health. According to the other vision, medicine is a collection of technologies that bring longer, higher-quality life to those who can afford them.If we choose this technological medicine, which is the direction an unregulated market is taking us, we are choosing a health care that focuses on individual health, a world in which we . . .
The new jetsetting
Authors: Trisha Greenhalgh
Journal: BMJ (2007)

Last week, I received six separate invitations to speak at conferences abroad. One agreed to reimburse my economy class air fare if I couldn't pay it myself. Another promised a business class flight, chauffeur driven limousine on the ground, a personal bodyguard if I wanted to check out the local night life, and a generous honorarium with tax all sorted. The others offered various packages and incentives in between. 

I turned them all down, mainly because in these days of global …
Regulation of Tumor Angiogenesis by Fastatin, the Fourth FAS1 Domain of βig-h3, via αvβ3 Integrin
Authors: Ju-Ock Nam, Ha-Won Jeong, Byung-Heon Lee, Rang-Woon Park, In-San Kim
Journal: Cancer Research (2005)

Abstract We previously reported that the FAS1 domains of βig-h3 bear motifs that mediate endothelial cell adhesion and migration via interactions with αvβ3 integrin and regulate angiogenesis. In the present study, we show that the fourth FAS1 domain, designated fastatin, inhibits endothelial adhesion and migration, not only to βig-h3, but also fibronectin and vitronectin, in a RGD-dependent manner. Fastatin and other FAS1 domains suppress endothelial cell tube formation and in vivo neovascularization in a Matrigel plug assay. The antiangiogenic activity of fastatin is associated with antitumor activity in mouse tumor models. Fastatin additionally induces apoptosis in several cells expressing αvβ3 integrin, including endothelial cells. Binding of fastatin to αvβ3 integrin inhibits phosphorylation of focal adhesion kinase, Raf, extracellular signal-regulated kinase, Akt, and mammalian target of rapamycin. Fastatin is thus the first endogenous angiogenesis regulator identified that inhibits both endothelial cell migration and growth by binding to αvβ3 integrin. Our data suggest that FAS1 domains from all possible forms of the four human FAS1 family proteins are potential endogenous regulators for pathologic angiogenesis. Moreover, FAS1 domains such as fastatin may be developed into drugs for blocking tumor angiogenesis.
THE TEETH AS A CAUSE OF PATHOLOGIC CONDITIONS IN THE THROAT, NOSE AND EAR.
Authors: KATE W. BALDWIN
Journal: JAMA (1903)

The little I have to say on this subject I shall put in as few words as possible. The best I can wish is that it may incite others to a more thorough investigation along the same lines. I feel that it is our duty to call the general practitioner's attention to this subject, as so many of the cases first come under his care. We are all too prone to look on the teeth as so many bones not intimately connected with the body as a whole, which, although useful, can easily be gotten rid of and more or less good substitutes readily obtained. The deciduous teeth are neglected because others are sure to take their places, and how often do we find the six-year molars considered in the same list. The child's face is usually washed at least once a day. In how many cases
Health Advice for International Travel
Authors: DAVID R. HILL
Journal: Annals of Internal Medicine (1988)

Travel to the developing world by U.S. citizens has been increasing. Exposure to illnesses such as travelers' diarrhea, malaria, and vaccine-preventable diseases challenges the internist to provide pre-travel advice. Each traveler's itinerary, duration of stay and medical history, including previous immunizations, should be reviewed. Immunizations that may be required by individual countries, such as yellow fever and cholera, may then be administered. Immunizations for diseases such as hepatitis, typhoid fever, and meningococcal disease can be given according to the type of exposure within each country. Restricting a traveler's diet to cooked foods and purified, carbonated, or heated beverages may prevent travelers' diarrhea and other enteric infections. Most travelers will want to carry medications to treat diarrhea promptly. Malaria is prevented by avoiding mosquitos, taking safe and appropriate antimalarials and treating malaria if it occurs. Preparation before travel may prevent medical complications.
Impaired sulfoxidation in patients with primary biliary cirrhosis
Authors: Bruce F. Scharschmidt, John R. Lake
Journal: Hepatology (1989)

An impaired sulfoxidation pathway has been implicated in the pathogenesis of chlorpromazine-induced hepatotoxicity. Since some patients with chronic chlorpromazine-induced cholestasis may have features of primary biliary cirrhosis, we studied the ability to sulfoxidate the amino acid analogue S-carboxymethyl-cysteine in 44 patients with primary biliary cirrhosis and in two control groups—one without liver disease and one with a variety of liver diseases other than primary biliary cirrhosis. Poor sulfoxidation was observed in 84 percent of the patients with primary biliary cirrhosis, as compared with 24 percent of patients with other liver diseases and 22 percent of normal controls (P < 0.0005 for both comparisons). Poor sulfoxidation did not correlate with the degree of hyperbilirubinemia or histologic severity of liver disease in any of the groups studied. There was an inverse correlation with age only in the patients with primary biliary cirrhosis (r = −0.44, P < 0.001). Liver transplantation was performed in six of the patients and improved sulfoxidation in five; in the four with primary biliary cirrhosis, sulfoxidation improved from poor to good or intermediate.
Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging
Authors: Xianjin Cui, Salome Belo, Dirk Krüger, Yong Yan, Rafael T.M. de Rosales, Maite Jauregui-Osoro, Haitao Ye, Shi Su, Domokos Mathe, Noémi Kovács, Ildikó Horváth, Mariann Semjeni, Kavitha Sunassee, Krisztian Szigeti, Mark A. Green, Philip J. Blower
Journal: Biomaterials (2014)

Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for (18)F-fluoride and 100% for (64)Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of (18)F from NPs, but no sign of efflux of (64)Cu.
Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin.
Authors: J Nip, H Shibata, D J Loskutoff, D A Cheresh, P Brodt
Journal: Journal of Clinical Investigation (1992)

Human melanoma is a highly metastatic cancer and the regional lymph nodes are generally the first site of metastasis. Adhesion to cryostat sections of human lymph nodes was therefore studied using two human melanoma models established from lymph node metastases, namely, MeWo cell lines of diverse metastatic potentials and a highly metastatic cell line of recent origin designated MIM/8. We found a good correlation between the metastatic potentials of the melanoma cells as measured in nude mice and their ability to adhere to cryostat sections of human lymph nodes. When adhesion to immobilized extracellular matrix proteins was measured, a significant increase in adhesion, which correlated with increased metastasis, was seen mainly on vitronectin and to a lesser extent on fibronectin. The adhesion to vitronectin and to the frozen sections were specifically blocked by an RGD-containing peptide, mAb 661 to vitronectin and mAb LM609 to integrin alpha v beta 3. FACS analysis revealed a significant and specific increase in cell surface expression of alpha v beta 3 on the metastatic cells as compared to the parent line. Together these results suggest that the adhesion of melanoma cells to lymph node vitronectin via the alpha v beta 3 receptor plays a role in the process of lymphatic dissemination.
Superiority of bortezomib, thalidomide, and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma: a randomized phase 3 PETHEMA/GEM study
Authors: Laura Rosiñol, Albert Oriol, Ana Isabel Teruel, Dolores Hernández, Javier López-Jiménez, Javier de la Rubia, Miquel Granell, Joan Besalduch, Luis Palomera, Yolanda González, Mª Asunción Etxebeste, Joaquín Díaz-Mediavilla, Miguel T. Hernández, Felipe de Arriba, Norma C. Gutiérrez, Mª Luisa Martín-Ramos, Mª Teresa Cibeira, Mª Victoria Mateos, Joaquín Martínez, Adrián Alegre, Juan José Lahuerta, Jesús San Miguel, Joan Bladé
Journal: Blood (2012)
Opposing roles for mammary epithelial-specific PPARγ signaling and activation during breast tumour progression
Authors: Anthony J Apostoli, Jennifer M Roche, Mark M Schneider, Sandip K SenGupta, Michael A Di Lena, Rachel E Rubino, Nichole T Peterson, Christopher JB Nicol
Journal: Molecular Cancer (2015)

Among women worldwide, breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths. Improved understanding of breast tumourigenesis may facilitate the development of more effective therapies. Peroxisome proliferator-activated receptor (PPAR)γ is a transcription factor that regulates genes involved in insulin sensitivity and adipogenesis. Previously, we showed, using 7,12-dimethylbenz [a] anthracene (DMBA)-treated haploinsufficient PPARγ mice, that PPARγ suppresses breast tumour progression; however, the PPARγ expressing cell types and mechanisms involved remain to be clarified. Here, the role of PPARγ expression and activation in mammary epithelial cells (MG) with respect to DMBA-mediated breast tumourigenesis was investigated. PPARγ MG knockout (PPARγ-MG KO) mice and their congenic, wild-type controls (PPARγ-WT) were treated once a week for six weeks by oral gavage with 1 mg DMBA dissolved in corn oil and maintained on a normal chow diet. At week 7, mice were randomly divided into those maintained on a normal chow diet (DMBA Only; PPARγ-WT: n = 25 and PPARγ-MG KO: n = 39) or those receiving a diet supplemented with the PPARγ ligand, rosiglitazone (ROSI, 4 mg/kg/day) (DMBA + ROSI; PPARγ-WT: n = 34 and PPARγ-MG KO: n = 17) for the duration of the 25-week study. Compared to DMBA Only-treated PPARγ-WTs, both breast tumour susceptibility and serum levels of proinflammatory and chemotactic cytokines, namely IL-4, eotaxin, GM-CSF, IFN-γ, and MIP-1α, were decreased among PPARγ-MG KOs. Cotreatment with ROSI significantly reduced breast tumour progression among PPARγ-WTs, correlating with increased BRCA1 and decreased VEGF and COX-2 protein expression levels in breast tumours; whereas, surprisingly DMBA + ROSI-treated PPARγ-MG KOs showed increased breast tumourigenesis, correlating with activation of COX-2. These novel data suggest MG-specific PPARγ expression and signaling is critical during breast tumourigenesis, and may serve as a strong candidate predictive biomarker for response of breast cancer patients to the use of therapeutic strategies that include PPARγ ligands.
Genetic Protection Against Atherosclerosis.
Authors: Kurt Biss
Journal: Annals of Internal Medicine (1969)

s1 May 1969Genetic Protection Against Atherosclerosis.Kurt Biss, M.D., F.A.C.P., C. Bruce Tyalor, M.D., Lena A. Lewis, Ph.D., Belma Mikkelson Kang-JeyHo, M.D., Ph.D.Kurt Biss, M.D., F.A.C.P.Search for more papers by this author, C. Bruce Tyalor, M.D.Search for more papers by this author, Lena A. Lewis, Ph.D.Search for more papers by this author, Belma Mikkelson Kang-JeyHo, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1074_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe East African nomadic Masai consume a life-long high-cholesterol diet consisting almost exclusively of milk, blood, beef, and goat meat. They are reported to be free of clinical coronary heart disease, and their cholesterol levels average from 110 to 150 mg/100 ml. This unusual pattern of high cholesterol intake and low serum cholesterol levels prompted studies of Masai and volunteers.Serum samples of 350 healthy and ill Masai were obtained which confirmed the previously reported observation. The Masai serum levels were about 100 mg below the American levels. Autopsies were performed on 10 Masai, 5 of whom were males over... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: De Kalb and Evanston, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhospholipid composition of various organs from larvae of the housefly, Musca domestica, fed on diets deficient in choline 1 May 1969Volume 70, Issue 5Page: 1074-1074KeywordsAtherosclerosisAutopsyBloodCholesterolCoronary heart diseaseDietGeneticsHypercholesterolemiaMeatMilk ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr viral DNA.
Authors: K Kawa-Ha, S Ishihara, T Ninomiya, K Yumura-Yagi, J Hara, F Murayama, A Tawa, K Hirai
Journal: Journal of Clinical Investigation (1989)

Lymphoproliferative disease of granular lymphocytes (LDGL) is a heterogeneous disorder and the pathogenesis is likely to be complex. Some patients with chronic active EBV (CAEBV) infection also have LDGL. To investigate the relationship between EBV infection and the pathogenesis of LDGL, we conducted a survey for EBV DNA sequences by Southern blot analysis of DNA obtained from the peripheral blood of seven patients with LDGL, including one with CAEBV infection. Interestingly, EBV DNA was detected in the sample from the patient with CAEBV infection, and in the samples from four other patients with CD3-LDGL. Moreover, a single band for the joined termini of the EBV genome was demonstrated in two samples, suggesting a clonal disorder of those LDGL. These findings strongly suggest that EBV may play a pathogenic role in some cases of LDGL.
Medical Mystery: Brown Eye and Blue Eye — The Answer
Authors: Benjamin Gesundheit, Mark Greenberg
Journal: New England Journal of Medicine (2005)

To the Editor: The Medical Mystery in the October 6 issue1 shows a 10-year-old boy with one brown and one blue eye, with mild ptosis and miosis of the lighter, left eye (Fig. 1). Both eyes respond equally to light and have normal vision; both are normal on funduscopic examination. The eyes of the boy's father are blue, and the mother's are gray. At 10 months of age, the boy was given a diagnosis of a left-sided paraspinal neuroblastoma (C7), extending to the upper thoracic vertebrae and entering the intraspinal canal, with bone marrow involvement (stage 4). After undergoing emergency . . .
Increased circulating concentrations and augmented myocardial extraction of osteoprotegerin in heart failure due to left ventricular pressure overload
Authors: Satu Helske, Petri T. Kovanen, Ken A. Lindstedt, Kaija Salmela, Jyri Lommi, Heikki Turto, Kalervo Werkkala, Markku Kupari
Journal: European Journal of Heart Failure (2007)