tbuckley/cabot-search huggingface dataset:
The Merchant and the Parrot: Mideastern Stories as Tools in Psychotherapy
Authors: Thomas H. Lewis
Journal: JAMA (1983)

This is a vanity press publication. Dr Peseschkian is a follower of the Baha'i religion and a physician practicing in Germany, presumably with Iranian expatriate patients. He has noted that resistance, repetition, and impasse are consulting room problems and, with the aid of his aunt and others, found that proverbs are useful in relieving the tensions of inquiry and confrontation. The analogies contained in stories from the classical poets, recited in the therapeutic session, lead patients to insight and self-therapy, much as the clever Scheherazade led the mentally ill sultan back to health. The method described in this book suggests that Dr Peseschkian is an innovative therapist. This impression is strengthened when one reads that he has developed a completely new psychotherapy called differential analysis, the discoveries of which are said to be described in two previous books, Positive Psychotherapy: Theory and Practice of a New Method, and Psychotherapy of
STUDIES ON THE COUMARIN ANTICOAGULANT DRUGS: THE PHARMACODYNAMICS OF WARFARIN IN MAN*
Authors: Robert A. O'Reilly, Paul M. Aggeler, Lois S. Leong
Journal: Journal of Clinical Investigation (1963)

Link (1) suggested in 1948 that the coumarin compound warfarin be used as a rodenticide.Its first human use was in a suicide attempt in 1952 (2).Although warfarin has been employed in- creasingly in the treatment of thromboembolic disorders (3-5), no published reports of its physi- ologic disposition in man have appeared, probably owing largely to the lack of a suitable method for its measurement in biologic fluids (6).Weiner, Brodie, and Burns (7, 8) stated that the half-life of warfarin in man is 90 hours, but did not include the assay method, or give supporting data.In 1953, Yuyama, Goto, and Umezu (9) described a colorimetric method for the estimation of warfarin in rat plasma, but apparently this method was never applied to man.Since 1954, several investigations of warfarin in the rat have appeared, including the studies of Garner (10), Eble (11), and Lin (12).Their methods, how- ever, were unpublished except as doctoral theses, or were not readily adaptable for studies in man.Recently, we described a spectrophotometric method for the estimation of warfarin in biologic fluids (13), and have used this method in the present study to investigate the pharmiacodynamics of warfarin in man.We determined the concentrations of warfarin in the plasma and of a warfarin metabolite in the urine of normal subjects after both oral and intravenous adminis- tration of the drug.Analysis of the data provided information on its absorption, elimination, ap- parent volume of distribution, and excretion.Differences in its biologic effect were evaluated by simultaneous measurements of its plasma con- centration and of prothrombin complex activity.
Review of Leonard J. Weber, Profits Before People? Ethical Standards and the Marketing of Prescription Drugs.<sup>1</sup>
Authors: Jerome P. Kassirer
Journal: The American Journal of Bioethics (2007)

Abstract 1. Bloomington, IN: Indiana University Press, 2006. 168 pp. $24.95, hardcover. Notes 1. Bloomington, IN: Indiana University Press, 2006. 168 pp. $24.95, hardcover.
Transcriptional regulators in hepatocarcinogenesis – Key integrators of malignant transformation
Authors: Mona Malz, Federico Pinna, Peter Schirmacher, Kai Breuhahn
Journal: Journal of Hepatology (2012)

Hepatocellular carcinoma (HCC) is one of the most frequent human malignancies with poor prognosis and increasing incidence in the Western world. Only for a minority of HCC patients, surgical treatment options offer potential cure and therapeutic success of pharmacological approaches is limited. Highly specific approaches (e.g., kinase inhibitors) did not significantly improve the situation so far, possibly due to functional compensation, genetic heterogeneity of HCC, and development of resistance under selective pressure. In contrast, transcriptional regulators (especially transcription factors and co-factors) may integrate and process input signals of different (oncogenic) pathways and therefore represent cellular bottlenecks that regulate tumor cell biology. In this review, we want to summarize the current knowledge about central transcriptional regulators in human hepatocarcinogenesis and their potential as therapeutic target structures. Genomic and transcriptomic data of primary human HCC revealed that many of these factors showed up in subgroups of HCCs with a more aggressive phenotype, suggesting that aberrant activity of transcriptional regulators collect input information to promote tumor initiation and progression. Therefore, expression and dysfunction of transcription factors and co-factors may gain relevance for diagnostics and therapy of HCC.
Serendipitous Detection of Cushing’s Disease by FDG Positron Emission Tomography and a Review of the Literature
Authors: TSUYOSHI KOMORI, WILLIAM H. MARTIN, ALAN L. GRABER, DOMINIQUE DELBEKE
Journal: Clinical Nuclear Medicine (2002)

A 70-year-old woman was referred for F-18 fluorodeoxyglucose (FDG) positron emission tomographic (PET) imaging of the brain to evaluate progressive dementia and neuropsychiatric symptoms. Although she had a history of hypertension and diabetes mellitus, she did not exhibit phenotypic features of Cushing’s disease. The FDG-PET images revealed marked FDG uptake in the pituitary gland but no evidence of degenerative dementia. Two macroadenomas were confirmed by magnetic resonance imaging. Endocrinologic evaluation revealed Cushing’s disease. After surgical resection of the tumors, the patient’s symptoms decreased markedly.
Serial 67Ga lung scanning in pulmonary eosinophilic granuloma.
Authors: S Javaheri, B W Levine, K A McKusick
Journal: Thorax (1979)

Chest radiographs and pulmonary function tests are used as non-invasive techniques for the clinical man- agement and guide to treatment in patients with diffuse interstitial pulmonary disease.The serial use of these tests may not give a true indication of the pathological months after treatment.Initial pulmonary function 6'Ga scan.Posterior view.(a) DiO "Ga, suggesting active inflammato *Supported by NIH Training Grant HL05767.Normal "Ga scan of lungs one mo tSupported in part by a grant from the John A Hartford Foundation.treatment.822 ruse uptake of )ry process.(b)
Incidence of liver disease in people with HFE mutations
Authors: G Willis
Journal: Gut (2000)

Most patients with haemochromatosis have mutations of the HFE gene. However, the risk to people with HFE mutations of developing disease manifestations of haemochromatosis is not known.To determine the risk of developing cirrhosis and liver cancer in individuals with HFE mutations in a population where few people were being treated for haemochromatosis.215 archive biopsy specimens of liver cancer (n=34) and cirrhosis (n=190) were retrieved from histology archives. Blood samples from 1000 individuals from the normal population were also collected. DNA was extracted from the biopsy specimens and exons 2 and 4 of the HFE gene were amplified using polymerase chain reaction. The products were analysed for the C282Y (845A) and H63D (187G) mutations.Three (8.8%) patients from the liver cancer group were homozygous for the C282Y mutation. Five (2.6%) patients from the cirrhosis group were homozygous for the C282Y mutation. One case fell in both the liver cancer and cirrhosis groups. C282Y homozygosity was thus significantly more frequent in both groups than in the normal population. These 215 cases are representative of a population of about 250 000 over 20 years. During this period we estimate that about 260 births or deaths of C282Y homozygous individuals occurred within this population.A diagnosis of liver cancer or cirrhosis is rare in the lifetime of individuals from this population who are homozygous for the C282Y mutation (2.5%; upper 95% confidence interval (CI) = 8%). Similarly liver disease is rare among C282Y/H63D compound heterozygotes (1%; upper 95% CI = 3.5%).
Effects of sino-atrial ischaemia on the heart rate response to phasic burst stimulation of the right cervical vagus in the dog
Authors: J. BILLETTE, J.-P. BONIN, A. ARSENAULT, P. GAUTHIER
Journal: Cardiovascular Research (1984)

Journal Article Effects of sino-atrial ischaemia on the heart rate response to phasic burst stimulation of the right cervical vagus in the dog Get access JACQUES BILLETTE, JACQUES BILLETTE * From the Department of Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada *Address for reprint requests: Jacques Billette, MD, PhD, Département de physiologie, Faculté de médecine, Université de Montréal, Case postale 6208, Succursale A, Montréal, Québec, Canada, H3C 3T8. Tel: (514) 343-7953. Search for other works by this author on: Oxford Academic PubMed Google Scholar JEAN-PIERRE BONIN, JEAN-PIERRE BONIN From the Department of Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar ANDRÉ ARSENAULT, ANDRÉ ARSENAULT From the Department of Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar PIERRE GAUTHIER PIERRE GAUTHIER From the Department of Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 8, August 1984, Pages 486–496, https://doi.org/10.1093/cvr/18.8.486 Published: 01 August 1984
Lyme Disease Associated with Fibromyalgia
Authors: Hal Dinerman, Allen C. Steere
Journal: Annals of Internal Medicine (1992)

▪Objective: To describe the clinical and laboratory findings as well as results of treatment in patients with Lyme disease associated with fibromyalgia. ▪Design: Observational cohort study. The mean duration of observation was 2.5 years (range, 1 to 4 years). ▪Setting: Diagnostic Lyme disease clinic in a university hospital. ▪Patients: Of 287 patients seen with Lyme disease during a 3.5-year period, 22 (8%) had fibromyalgia associated with this illness, and 15 (5%) participated in the observational study. ▪Measurements: Symptoms and signs of fibromyalgia, immunodiagnostic tests for Lyme disease, and tests of neurologic function. ▪Results: Of the 15 patients, 9 developed widespread musculoskeletal pain, tender points, dysesthesias, memory difficulties, and debilitating fatigue a mean duration of 1.7 months after early Lyme disease; the remaining six patients developed those symptoms during the course of Lyme arthritis. At the time of our evaluation, late in the course of their illness, 11 patients had positive immunoglobulin (lg) G antibody responses to Borrelia burgdorferi by enzyme-linked immunosorbent assay (ELISA), one had a positive Western blot, and the three seronegative patients had positive cellular immune responses to borrelial antigens. Four patients had abnormal cerebrospinal fluid analyses that showed an elevated protein level, a slight pleocytosis, or intrathecal antibody production to the spirochete. The signs of Lyme disease resolved with antibiotic therapy, usually intravenous ceftriaxone, 2 g/d for 2 to 4 weeks, except in one patient with persistent knee swelling. However, 14 of the 15 patients continued to have symptoms of fibromyalgia. Currently, only one patient is completely asymptomatic. ▪Conclusions: Lyme disease may trigger fibromyalgia, but antibiotics do not seem to be effective in the treatment of the fibromyalgia.
Endocardial Fibrosis Associated with Methysergide Therapy.
Authors: Dhirendra S. Bana
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Endocardial Fibrosis Associated with Methysergide Therapy.Dhirendra S. Bana, M.D., Perry S. MacNeal, M.D., F.A.C.P., Philip M. LeCompte, M.D., Yogendra Shah, M.D., John R. Graham, M.D.Dhirendra S. Bana, M.D.Search for more papers by this author, Perry S. MacNeal, M.D., F.A.C.P.Search for more papers by this author, Philip M. LeCompte, M.D.Search for more papers by this author, Yogendra Shah, M.D.Search for more papers by this author, John R. Graham, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-821_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMethysergide is probably causally related to the development of cardiac lesions in some patients taking this drug for headaches. We report our observations of the development and progress of cardiac murmurs in 36 of our own patients and 12 patients of other physicians, all taking methysergide. Murmurs were predominantly of aortic and mitral valve origin. Twelve patients had complete and 15 patients partial regression of the murmurs, 6 to 70 months after stopping use of the drug. Nine patients had retroperitoneal fibrosis, and two patients had pleuropulmonary fibrosis in addition to endocardial lesions. In four patients pathological material was available... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts, and Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug Action, Reaction, and Interaction 1 May 1973Volume 78, Issue 5Page: 821-822KeywordsDrugsFibrosisLesions Issue Published: 1 May 1973 PDF DownloadLoading ...
Vagal control of gastric alkaline secretion.
Authors: R W Stockbrugger
Journal: Gut (1987)

Airway organoids can be successfully generated from primary airway epithelial cells, recapitulating the architecture, polar organization, and key functions of the in vivo tissue. However, the closed organoid structure limits the accessibility to the luminal apical cell surface, which is exposed to the environment in vivo. This inaccessibility hinders the utilization of airway organoids in assays examining host-pathogen interactions and responses to environmental stimuli, both of which occur primarily at the apical surface. To address this limitation, we have developed PneumaCult™ Apical-Out Airway Organoid (AOAO) Medium, which supports the fast and efficient generation of airway organoids exposing their apical side to the environment in the absence of an extracellular matrix hydrogel. To generate AOAOs, two-dimensional expanded human bronchial epithelial cells (HBECs) were seeded in PneumaCult™ AOAO Medium in micropatterned [AggreWell™400] plates to promote cell aggregation. The aggregates were then transferred to suspension culture in fresh PneumaCult™ AOAO, and incubated at 37°C until they differentiated into AOAOs. These organoids can be generated from HBECs from a multitude of different passages and display high culture homogeneity, with low inter-donor size variability (average diameter 74 ± 4 μm at p3, n=3). The organoids are mainly composed of ciliated cells (61 ± 16% of all cells at p3) that display outward-facing, beating cilia and KRT5-positive basal cells (n=3). The easy access to the apical surface of the epithelium and scalability of this culture system offer a powerful in vitro model suitable for studying host-pathogen interactions and high-throughput antiviral drug screening.
Megaloblastic Anaemia of Infancy Treated with Folic Acid
Authors: F. Walt, S. Holman, P. Naidoo
Journal: BMJ (1957)

DiscussionThe results of this investigation do not support some of the impressions recorded by Robertson and Leonard.The present results' do not exclude the possibility of individual rare syndromes, such as the single cases of " collagen disease " reported by these auithors, being caused by T.A.B.T. inoculation.That unit medical officers were all too ready to ascribe miscellaneous morbid conditions to inoculation was exemplified by occasional cases of traumatic synovitis belonging to the control group being labelled " T.A.B.T. arthropathy."It appeared that many junior medical officers had been warned by their professional seniors of the im- portant aetiological role of T. A.B.T. in what Ogilvie (1954) terms " ephebiatrics."It should be remembered that T.A.B.T. is usually given at a time when the recruit is adapting himself to a new environment, and that the immediate post-inoculation period is the time when his reaction to "herd life" may be expected to become apparent.Although the admission of 1% to sick quarters following T.A.B.T. inoculation seems reasonably small at first sight, it can cause considerable administrative embarrassment when large numbers are involved.This admission rate, however, was less than that due to vaccination (1.5%). SummaryA survey was carried out on 55,459 R.A.F. and W.R.A.F.recruits to determine the morbidity following T.A.B.T. inoculation.The incidence of disease in the test group was significantly lower than that in the con- trols; nearly all this difference was accounted for by " diseases caused by infection " and persisted in " dis- eases of the upper respiratory tract."The admission rate to sick quarters following T.A.B.T. inoculation was 1 %, and following smallpox vaccination 1.5%.No difference in immediate local and general reactions could be detected between subcutaneous and intra- muscular T.A.B.T. inoculation.There was no significant difference between the re- actions to T.A.B.T. inoculation classified according to the blood groups of the patients.T.A.B.T. does not appear to give rise to false-positive Kahn reactions, but vaccination may cause up to 2% false-positive results.No cases of peripheral neuritis were seen.We thank the Medical Statistical Branch of the Air Ministry for their willing assistance, and particularly Mr. E. W. N.
Gastritis duodenitis, and circulating levels of gastrin in duodenal ulcer before and after vagotomy.
Authors: D D Meikle, K B Taylor, S C Truelove, R Whitehead
Journal: Gut (1976)

Biopsy specimens have been taken from five standard sites in the stomach and from the duodenal bulb in order to investigate the association of gastritis and duodenitis with duodenal ulcer. Twenty patients with chronic duodenal ulcer were investigated in this manner and in addition had gastric secretion tests and a radio-immune assay of serum gastrin under differing conditions. The patients were then treated either by a truncal vagotomy and pyloroplasty (TVP) or by a highly selective vagotomy without a drainage procedure (HSV). All the investigations were repeated three months postoperatively. Duodenal ulcer was usually associated with gastriitis, although this varied in extent and severity from patient to patient. In nearly all the patients, gastritis was present at the pyloric end of the stomach and along the lesser curve. In more than half of the patients, gastritis was also present in the body of the stomach but the fundus was usually spared. Chronic duodenitis was found in the duodenal bulb in all these patients. After vagotomy there was a marked increase in both the extent and severity of the proximal gastritis in both treatment groups but the distal gastritis remain almost unchanged. There was little change in the incidence of duodenitis after vagotomy but its severity was lessened. No correlation was found between the peak acid output (PAO) in response to Histalog and the severity of the gastritis or the duodenitis either before or after operation, with one exception. The postoperative PAO was significantly less in those patients who developed a severe proximal gastritis after vagotomy. No relationship was found between the severity of the distal gastritis and the levels of serum gastrin. No correlation was found between either the basal or peak acid output and the corresponding serum gastrin levels before or after vagotomy.
Respiratory distress due to nasopharyngeal hamartoma.
Authors: B. D. Birt, E. B. Knight-Jones
Journal: BMJ (1969)

Respiratory Distress Due to Nasopharyngeal HamartomaAfter operation recovery was immediate, and his breathing and feeding had become normal in every way.When last seen, at the age of 18 months, -he appeared to be a normal child.Obstruction of the nasopharyngeal airway in young infants is associated with restless sleep, feeding difficulties, and attacks of breathlessness, stridor, and cyanosis (Thomson and Negus, 1948).The following report describes the case of an infant with a rare nasopharyngeal tumour who showed all these features, and in whom the diagnosis was delayed by a misleading physical sign. CASE REPORTFrom the age of 1 month the patient had noisy breathing, feeding difficulties resulting in slow weight gain, and occasional transient cyanosis.At the age of 3 months he caught a cold and was admitted as an emergency case with inspiratory stridor and severe respiratory distress.Direct laryngoscopy showed moderate laryngeal oedema, and a 4'5-mm.Jackson Rees nasoendotracheal tube was passed.The symptoms recurred on extubation, and at a second direct laryngoscopy prominent mucosal folds extending from the posterior faucial pillars to the epiglottis were found.It appeared that these might prolapse into the larynx, and they were therefore excised.Unfortunately there was no improvement, and he was transferred to the Middlesex Hospital with a nasoendotracheal tube in situ.Clinical examination of the respiratory, cardiovascular, and neuro- logical systems showed no abnormality.A nasogastric tube could
A TYPHOID CARRIER
Authors: C. B. Sylvester
Journal: JAMA (1925)

<h3>History.</h3> —A farmer, aged 39, of an Oxford County town, Maine, married, having two living children, examined, Feb. 3, 1925, complained of dizziness and headaches, despondency, indigestion, flatulence, nausea and vomiting, pain in the stomach after eating, and weakness of the left arm and leg with paresthesia. Part of the time he was very hoarse; the taste in his mouth was so bad that he chewed tobacco constantly. He had various rheumatic and neuralgic attacks, diagnosed as neuritis, focal infections, nervous exhaustion or spinal subluxation, depending on the diction of his various medical attendants. The family history was negative. As a child he had been well till 10 years of age, when he had typhoid fever. There had been no subsequent illness worthy of memory, though he had always complained of indigestion and flatulence. He lived with his parents on an isolated farm. He had worked at the "Balsams," Dixville