tbuckley/cabot-search huggingface dataset:
An End to Federal Regulation: The Good, the Bad, and the Unnecessary
Authors: William J. Curran
Journal: New England Journal of Medicine (1982)

THE present administration in Washington is vigorously dismantling federal regulatory programs. Old-time political opponents of even the most traditional and seemingly secure public control and surveillance programs are, at long, long last, having their day. The regulators are being shoved out into the cold, and their many rules, regulations, and statutes are being fed into the shredders in preparation for public burning.There is probably some good in all such purging. There are always identifiable excesses and unnecessary regulatory growths cultivated in the name of the greater public good. However, the danger with purging and pruning is that the enthusiasm . . .
Time course and mechanisms of endo-epicardial electrical dissociation during atrial fibrillation in the goat
Authors: Jens Eckstein, Bart Maesen, Dominik Linz, Stef Zeemering, Arne van Hunnik, Sander Verheule, Maurits Allessie, Ulrich Schotten
Journal: Cardiovascular Research (2010)

AimsThis study aims to determine the degree and mechanisms of endo-epicardial dissociation of electrical activity during atrial fibrillation (AF) and endo-epicardial differences in atrial electrophysiology at different stages of atrial remodelling.
Reducing Mother-to-Infant Transmission of HIV — The Door Remains Open
Authors: Daniel V. Landers, Richard L. Sweet
Journal: New England Journal of Medicine (1996)

As of the end of 1995, over 90 percent of the reported cases of AIDS in children were acquired through mother-to-infant transmission of the human immunodeficiency virus (HIV).1 Nearly all HIV infections in children are now thought to be acquired in this manner. The prospective, observational study by Landesman et al. of obstetrical factors associated with mother-to-infant transmission that appears in this issue of the Journal 2 has major implications for the care of pregnant women with HIV and the choices they face.In late 1994, a highly publicized report in the Journal 3 from AIDS Clinical Trials Group Protocol 076 showed . . .
Accelerated development of collapsing glomerulopathy in mice congenic for the HIVAN1 locus
Authors: Ka T. Chan, Natalia Papeta, Jeremiah Martino, Zongyu Zheng, Rachelle Z. Frankel, Paul E. Klotman, Vivette D. D'Agati, Richard P. Lifton, Ali G. Gharavi
Journal: Kidney International (2008)
Outcomes of the RESTOR-MV Trial (Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral Valve)
Authors: Eugene A. Grossi, Nirav Patel, Y. Joseph Woo, Judith D. Goldberg, Charles F. Schwartz, Valavanur Subramanian, Ted Feldman, Robert Bourge, Norbert Baumgartner, Christopher Genco, Scott Goldman, Marco Zenati, J. Alan Wolfe, Yugal K. Mishra, Naresh Trehan, Sanjay Mittal, Shulian Shang, Todd J. Mortier, Cyril J. Schweich
Journal: Journal of the American College of Cardiology (2010)
Screening for NIDDM: Opportunities for detection, treatment, and prevention
Authors: William C Knowler
Journal: Diabetes Care (1994)

Although non-insulin-dependent diabetes mellitus (NIDDM) is a common and serious disease, in the U. S. about half of the people with this disease are unaware of it. Approximately four million Americans 20–74 years of age have undiagnosed NIDDM (1), making this disease a candidate for early detection and treatment (2). I will present my views on the principles of screening as applied to NIDDM and on the benefits, costs, methods, and unanswered questions regarding the screening and diagnosis of this disease.
The role of angiotensin converting enzyme and angiotensin ii type 1 receptor gene polymorphisms in patients with nonarteritic anterior ischemic optic neuropathy
Authors: Ophira Salomon, Rima Dardik, David M Steinberg, Shimon Kurtz, Nurit Rosenberg, Joseph Moisseiev, Ruth Huna-Baron
Journal: Ophthalmology (2000)
Incidence of Prostate Cancer in Sicily: Results of a Multicenter Case-Findings Protocol
Authors: F. Aragona, P. Pepe, M. Motta, A. Saita, G. Raciti, P. La Rosa, D. Nicolosi, A. Dammino, G. Minaldi, G. Rizza, G. Azzarello, C. Aragona, S. Rotondo, L. Orestano, A. Serrao, F. Amico, G. Dibenedetto, V. Cosentino, C. Iurato, S. Raffino, M. Gulletta, A. Calarco, Q. Paola, M. Barbera, V. Gulino, G. Capizzi, F. Orestano
Journal: European Urology (2004)
Cigarette smoking as risk factor for late fetal and early neonatal death.
Authors: S. Cnattingius, B. Haglund, O. Meirik
Journal: BMJ (1988)

Risk factors for late fetal death and early neonatal mortality were examined in a population based prospective study. Practically all Swedish births between 1983 and 1985 were included, 281,808 births in all. The overall rates of late fetal death and early neonatal mortality were 3.5 and 3.1 per 1000, respectively. About 30% of the pregnant women were recorded as being daily smokers. Logistic regression analyses showed significant relative risks for late fetal death for high maternal age (1.4), nulliparity (1.4), multiparity (greater than or equal to 2) (1.3), smoking (1.4), and multiple births (2.8). Significant relative risks for early neonatal mortality were found for multiple births (4.9) and smoking (1.2). Smokers aged under 35 faced a relative risk of late fetal death ranging from 1.1 to 1.6, while the risk for late fetal death was doubled if the mothers were aged 35 years or more and smoked. In countries like Sweden, where maternal cigarette smoking is prevalent, smoking may be the most important preventable risk factor for late fetal death.
Comparison of continuous and intermittent papaveretum after cholecystectomy.
Authors: H Dudley, P C Rutter
Journal: BMJ (1980)

conceded, a multifactorial disease then -high salt intake may play a significant permissive role without necessarily requiring that hypertensives consume more than normotensives.This high salt intake may allow the clinical expression of a number of other genetic and environmental factors.A parallel situation is seen in the epidemio- logy of diabetes.Australian Aborigines have a high prevalence of diabetes yet there is no difference in the calorie intake between diabetics (1500 of the population) and non- diabetics'.Similar findings have been derived from various other ethnic groups.Yet no one would deny that calorie intake is the single most important environmental factor involved in the expression of insulin-dependent diabetes: increasing calorie intake results in the emergence of diabetes in populations, while a reduced calorie intake represents the single best treatment modality for established diabetes.Parenthetically, hypertension is also seen in more rather than less urbanised Aboriginals with a greater age-related incre- ment in the former.2Aboriginals are known to use large amounts of salt but regrettably no sodium consumption or excretion data was obtained during our studies.For the present, and particularly in the light of other studies, the data of Beevers and colleagues do not exclude salt as being a significant (even major) cause of hypertension in the community.
Prophylactic Endoscopic Coagulation to Prevent Bleeding After Wide-Field Endoscopic Mucosal Resection of Large Sessile Colon Polyps
Authors: Farzan F. Bahin, Mahendra Naidoo, Stephen J. Williams, Luke F. Hourigan, Donald G. Ormonde, Spiro C. Raftopoulos, Bronte A. Holt, Rebecca Sonson, Michael J. Bourke
Journal: Clinical Gastroenterology and Hepatology (2014)
Assessment of adrenal function in cirrhotic patients: Salivary cortisol should be preferred
Authors: Arnaud Galbois, Marika Rudler, Julien Massard, Yvonne Fulla, Abdelhai Bennani, Dominique Bonnefont-Rousselot, Vincent Thibault, Stéphanie Reignier, Anne Bourrier, Thierry Poynard, Dominique Thabut
Journal: Journal of Hepatology (2010)
WHO and science publishers team up on online register of trials
Authors: Fiona Fleck
Journal: BMJ (2004)

The World Health Organization has teamed up with a group of biomedical publishing experts to register its trials on an online database. From this month all randomised controlled trials that have been approved by the WHO's ethics review board will be registered on the database run by Current Controlled Trials, a London based company, under the company's unique international standard randomised controlled trial number (ISRCTN).

The move is a …
Studies of Australia-SH Antigen in Sporadic Viral Hepatitis in London
Authors: Y. E. Cossart, J. Vahrman
Journal: BMJ (1970)

Sera from 87 patients with acute sporadic viral hepatitis were tested for the presence of the Australia-SH antigen. Forty-three were positive by the complement-fixation test, but only 24 of these reacted in the gel-diffusion test. The antigen was equally distributed in infectious and serum hepatitis. The relationship of naturally occurring antigen-positive hepatitis to the Willow-brook MS-2 type is discussed.
FDA approves lithotripter for kidney stone shattering
Authors: C. Marnick
Journal: JAMA (1985)

The Food and Drug Administration has approved an ultrasonic kidney stone shattering device (<i>JAMA</i>[MEDICAL NEWS] 1983;249:2434-2435). This version of the device, technically called a lithotripter, was recommended for approval last May after extensive review of the clinical data by the FDA's advisory panel on gastroenterological and urological devices. The FDA commissioner acted on this advice just before the new year. This lithotripter has been used in treating some 10,000 patients with kidney stones in studies over the past five years in West Germany, as well as in several centers in the United States over the last year and a half. Currently, six centers in the United States have the device. The lithotripter was originally developed in West Germany by Dornier System of Friedrichshafen. The FDA has approved the lithotripter for treating stones formed in the renal calyx, pelvis, and upper third of the ureter. It is not suitable for
Photocarcinogenic risk of narrowband ultraviolet B (TL-01) phototherapy: early follow-up data
Authors: R.J. Black, A.T. Gavin
Journal: British Journal of Dermatology (2006)

Conflicts of interest: none declared. Sir, We read with interest the article by Man et al.1 following on from their original notification.2 We too have recently compared all patients treated with narrowband ultraviolet UVB (TL‐01) in the dermatology department of Craigavon Area Hospital (a large regional hospital in Northern Ireland) against the Northern Ireland Cancer Registry. Since 1993, 484 patients have received at least one course of TL‐01 UVB (a course being ≈ 18 treatments) for a variety of skin disorders including psoriasis, eczema and polymorphic light eruption, the majority being for psoriasis. Levels of cancer in these patients were verified by the Northern Ireland Cancer Registry, a 'population‐based registry (1·7 million) which receives data electronically from multiple sources including all pathologically diagnosed skin cancers'. Levels of cancer in the cohort of patients were as expected for rates in the general population. Four patients were found who cross‐referenced with the register; of these none had developed skin cancer although one patient was identified who had received TL‐01 UVB as treatment for pre‐existing mycosis fungoides. The three remaining cases were unrelated: two cases of carcinoma in situ of the cervix and one hydatidiform mole of pregnancy. Both conditions were present before TL‐01 UVB therapy. The rates of skin cancer in Northern Ireland (figures obtained from the Northern Ireland Cancer Registry) are shown in Table 1.
TCT-601 Comparison of sirolimus-eluting stents with biodegradable polymer versus zotarolimus-eluting stents with durable polymer assessed by optical coherence tomography: The ALSTER-OCT registry
Authors: Christian H. Heeger, Felix Lesche, Maximilian Fenski, Laura Hildebrand, Felix Meincke, Andreas Busjahn, Karl-Heinz Kuck, Martin W. Bergmann
Journal: Journal of the American College of Cardiology (2014)
Appropriate Use Criteria in Echocardiography
Authors: William Armstrong, Kim A. Eagle
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
STUDIES IN FERMENT ACTION
Authors: James W. Jobling, Carroll G. Bull
Journal: The Journal of Experimental Medicine (1913)

1. A single intravenous injection into dogs of a sufficient number of freshly washed typhoid bacteria produces the symptoms and pathology that characterize anaphylaxis in these animals. 2. These effects are not produced by the coagulable protein-free filtrate from a fresh emulsion, while a similar filtrate from an emulsion digested with leucoprotease is very potent, the toxic portion of the bacterial bodies being changed from a coagulable to a non-coagulable state. 3. The symptoms and pathology described are not specific, since they can be produced by substances other than typhoid toxins. 4. Digestion with leucoprotease furnishes a method of liberating toxic substances from typhoid bacteria resembling the processes of nature more closely than the methods heretofore used. 5. The toxic substances thus liberated are not destroyed by a heat and acid precipitation of the coagulable proteins, and are of the nature of primary proteoses.
The Kelly in the Belly — Some Comments on Malpractice
Authors: Howard M. Spiro
Journal: New England Journal of Medicine (1977)

As an academic clinician, I have not really been concerned with the rise in malpractice suits and the ballooning of medical insurance rates that followed. Of course, I have been aware of the ferment, but no more intoxicated by it than the neighbors of a brewery by the smell of yeast. Indeed, visiting California during the doctors' strike of last year, I felt somewhat aloof from the omphalologist lamenting his $15,000-a-year malpractice insurance fees as he packed for his ski lodge in Utah. Recently, however, I have come to realize how much more than money is involved in physicians' reactions . . .
Toxicity of Tricyclic Antidepressants
Authors: John C. Ballin
Journal: JAMA (1975)

Since the introduction of imipramine hydrochloride (Tofranil) in 1959, the tricyclic compounds have played an increasingly important role in the treatment of depressed patients. Today, six compounds of this therapeutic class are marketed and one of them, amitriptyline (Elavil) hydrochloride, ranks 29th in order of prescription frequency in the United States.1The most recentNational Disease and Therapeutic Indexaudit indicates that, in a one-year period, American physicians wrote more than 18 million prescriptions for tricyclic compounds and more than 6 million prescriptions for these drugs combined with other agents.1  The tricyclic antidepressants have largely replaced the psychomotor stimulants (amphetamines and methylphenidate) in the treatment of depression; they are generally more effective than the monoamine oxidase inhibitors in moderate and severe depression, especially the endogenous types.2Recent evidence indicates that imipramine and perhaps other tricyclic compounds are also useful in the management of childhood enuresis. It is
Abstract 5106: Circulating MACC1 transcripts are elevated in pancreatic cancer patient blood and correlate to locally advanced disease.
Authors: Ulrike S. Stein, Pia Herrmann, Christian Fischer, Peter M. Schlag, Katharina Detjen
Journal: Cancer Research (2013)

Abstract Pancreatic cancer is a highly aggressive malignancy with a 5-year survival of &amp;lt; 5%. Late diagnosis, lack of prognostic markers and poor response to radiation and chemotherapies all contribute to the dismal prognosis. Surgery represents the sole curative treatment option. However, success is limited by invasive growth and metastatic spread, which frequently precede the onset of clinical symptoms and hence diagnosis. Recently, we identified the novel gene metastasis-associated in colon cancer-1 (MACC1). MACC1 is a prognostic indicator for metastasis formation linked to metastasis-free survival of colorectal cancer patients. Circulating MACC1 transcripts in colorectal cancer patient plasma predict metastasis and survival. Correlations of MACC1 expression levels with tumor progression, recurrence and metastasis have meanwhile been reported for several cancers, e.g. gastric, lung and hepatocellular cancer. Here, we addressed the role of MACC1 in pancreatic cancer. Immunohistochemical analysis of MACC1 in cryosections of human pancreatic cancer revealed strong reactivity of tumour duct epithelial cells, but not in the desmoplastic stroma. In contrast, weak immunoreactivity was present in non transformed pancreatic tissues, suggesting an induction of MACC1 in pancreatic malignancy. We furthermore analyzed blood levels of circulating MACC1 transcripts in pancreatic cancer patients. Circulating MACC1 transcript levels were elevated in pancreatic cancer patients, when compared to healthy volunteers. MACC1 transcript levels furthermore correlated to peripancreatic infiltration, but not to tumour size, tumor grading or angioinvasion. Thus, MACC1 expression is induced in pancreatic cancer, which is reflected by increased circulating transcript levels in blood as well as high protein levels in the primary tumors. The correlation of MACC1 transcript levels with peripancreatic infiltration suggests a distinct function of MACC1 in pancreatic cancer cell biology, which translates into distinct clinical features of disease progression. Circulating MACC1 might therefore help to personalize treatment decisions in situations such as (neo-)adjuvant chemotherapy. Citation Format: Ulrike S. Stein, Pia Herrmann, Christian Fischer, Peter M. Schlag, Katharina Detjen. Circulating MACC1 transcripts are elevated in pancreatic cancer patient blood and correlate to locally advanced disease. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5106. doi:10.1158/1538-7445.AM2013-5106
Increased susceptibility to silicosis and TNF-alpha production in C57BL/6J mice.
Authors: Y Ohtsuka, M Munakata, H Ukita, T Takahashi, A Satoh, Y Homma, Y Kawakami
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Toxic oxygen species and several proinflammatory cytokines are involved in the pathogenesis of silicosis. In order to understand whether factors that lead to susceptibility to ozone are also important in silicosis or not, we examined ozone-sensitive C57BL/6J mice and ozone-resistant C3H/HeJ mice as models of silicosis. We also analyzed the production of proinflammatory cytokines in both the acute and the chronic phases. On Day 2 after silica injection, the ozone-resistant C3H/HeJ mice showed significantly higher cellular responses as recognized by bronchoalveolar lavage (BAL) cell counts than did the C57BL/6J mice. In the chronic phase (Day 28 after silica injection), the ozone-sensitive C57BL/6J mice showed significantly greater responses to instilled silica judged by total protein and cell number in BAL fluid, hydroxyproline content, and histology than the ozone-resistant C3H/HeJ mice. TNF-alpha production by BAL cells after silica exposure was significantly higher in C57BL/6J mice than in C3H/HeJ mice in the chronic phase, whereas there was no significant difference in IL-1 alpha production between both strains of silica-injected mice. Also, the control C57BL/6J mice had significantly higher secretions of TNF-alpha than did the control C3H/HeJ mice in the acute phase. These results suggest that ozone-sensitive C57BL/6J mice are also more susceptible to silicosis than are ozone-resistant C3H/HeJ mice, and that the initial lower cellular responses and increase in TNF-alpha production may be related to the higher level of inflammatory and fibrotic response in the C57BL/6J mice.
Atran's evolutionary psychology: “Say it ain't just-so, Joe”
Authors: James Maffie
Journal: Behavioral and Brain Sciences (1998)

Atran advances three theses: our folk-biological taxonomy is (1) universal, (2) innate, and (3) the product of natural selection. I argue that Atran offers insufficient support for theses (2) and (3) and that his evolutionary psychology thus amounts to nothing more than a just-so story.
What Are the Risks of General Surgical Abdominal Operations in Patients With Cirrhosis?
Authors: J. Michael Henderson
Journal: Clinical Gastroenterology and Hepatology (2010)

What Are the Risks of General Surgical Abdominal Operations in Patients With Cirrhosis?T he report in this issue from the Mount Sinai group on "Improved patient selection and operative outcome following abdominal operations in patients with advanced cirrhosis," 1 raises old, and new questions.What are the salient points, and are there indeed new lessons to learn along this oft trod path?The main lessons for the general surgeon faced with this problem and for the gastroenterologist and/or hepatologist asked to help take care of such patients are in patient selection and management. Patient SelectionPatient selection for abdominal surgical procedures changes when a patient has cirrhosis.It is often said in the context of surgery that "There is no such thing as a good cirrhotic patient," but this is precisely what patient selection is all about.Decision-making on whether or not to perform general surgical procedures on patients with cirrhosis depends on many factors, and at the end of the day, the decision needs to be made by the patient and the surgeon balancing all such factors.
Clinical Spectrum of Pharyngeal Gonococcal Infection
Authors: Paul J. Wiesner, Evelyn Tronca, Paul Bonin, Alf H. B. Pedersen, King K. Holmes
Journal: New England Journal of Medicine (1973)

Neisseria gonorrhoeae was isolated on selective medium from the pharynx of 150 patients, including 125 examined during a nine-month prospective study. The prevalence of neisseria species in 2,224 patients at a venereal-disease clinic was N. meningitidis, 17.2 per cent, N. gonorrhoeae, 5.6 per cent, and N. lactamicus, 1.9 per cent. Among patients with gonorrhea, gonococcal pharyngeal infection was found in 20.9 per cent of homosexual men, 10.3 per cent of women, and only 3.2 per cent of heterosexual men. Gonococcal pharyngeal infection was correlated with the practice of fellatio (p less than 0.001), and 4.2 per cent of patients who practiced fellatio had infection of the pharynx alone. Symptoms of pharyngitis were also correlated with practice of fellatio (p less than 0.0001), but not with gonococcal pharyngeal infection. However, N. gonorrhoeae did appear responsible for pharyngitis in selected patients, and pharyngeal gonococcal infection was the only apparent source of disseminated gonococcal infection in five patients. Procaine penicillin G and tetracycline regimens were effective in treatment of pharyngeal gonococcal infection, but spectinomycin was not.
Platelet particle formation by anti–GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase
Authors: Michael A. Nardi, Yelena Gor, Steven J. Feinmark, Fang Xu, Simon Karpatkin
Journal: Blood (2007)