tbuckley/cabot-search huggingface dataset:
The Effect of Terbutaline on Cardiac Function in Patients With Stable Chronic Obstructive Lung Disease
Authors: Ettayapuram V. Sunderrajan
Journal: JAMA (1983)

The effect of 0.25 mg of terbutaline sulfate, a beta 2-adrenergic agent, on the right and left ventricular ejection fractions (RVEF and LVEF, respectively) was studied in 30 patients with severe stable chronic obstructive pulmonary disease (COPD) with a mean forced expiratory volume in 1 s of 0.79 +/- 0.06 L. All bronchodilator therapy was withdrawn 48 hours before the study. The ECG-synchronized gated equilibrium radionuclide ventriculography showed decreased RVEF in 27 patients and LVEF in 16 patients. Both the RVEF and LVEF significantly increased after the terbutaline injection; this increase was noted both in patients with normal and decreased ejection fractions. We conclude that the increase in ejection fractions after terbutaline injection may contribute to the good clinical response to this drug seen in patients with severe stable COPD even though the bronchodilator effect may be minimal.
Prospective study of hepatitis B vaccination in patients with chronic hepatitis C
Authors: V. Wong, T. G Wreghitt, G. J M Alexander
Journal: BMJ (1996)

Chronic hepatitis C results in liver disease, cirrhosis, and hepatocellular carcinoma. Its prevalence is estimated to be 70-92% among intravenous drug misusers,1 who are also at risk of parenterally or sexually transmitted hepatitis B. Coinfection with hepatitis B virus may accelerate underlying liver damage due to hepatitis C.2

Effective vaccines against hepatitis B have been available for a decade.3 Universal vaccination is being adopted in countries where hepatitis B is common. When vaccination has been targeted at promiscuous people and intravenous drug misusers uptake has been suboptimal and the incidence of hepatitis B has increased.4 5 We therefore investigated whether carriers of hepatitis C were being vaccinated against hepatitis B.

We prospectively studied 126 consecutive patients attending our hepatology clinic who had positive …
A NOTE ON THE ACTION OF APOLYSIN.
Authors: DAVID CERNA
Journal: JAMA (1896)

Recent literature concerning antipyretics and analgesics has brought to the notice of the profession several new drugs, among which<i>apolysin</i>seems to occupy a prominent place. Through the courtesy of a new York drug firm that kindly furnished me with a considerable amount of the new medicament, I have been enabled to conduct a series of experiments in the physiologic laboratory of the University of Texas, at Galveston, the results of which I shall endeavor to embody in this brief report. Apolysin is a substance closely related to phenacetin. Like the latter drug apolysin contains paraphenetidin. In phenacetin, however, the paraphenetidin of the amide group (NH<sub>2</sub>) one atom of hydrogen is replaced by an acetic acid radical; while in apolysin the atom of hydrogen of the paraphenetidin of the amide group is substituted by a citric acid radical. It may be said in this connection, that a combination of
Use of Emerging Lipoprotein Risk Factors in Assessment of Cardiovascular Risk
Authors: Scott M. Grundy
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician First, Surgeon Second
Authors: Joseph M. Primrose
Journal: JAMA (1976)

To the Editor.—  Clearly, even though at the moment the surgeon appears to have the upper hand, the time has not yet come for the  to throw in the sponge (235:637, 1976).  Being a young board-certified surgeon and a card-carrying, dues-paying colleague (pardon the expression) in the American Medical Association, I was puzzled to read that the only organized group representing all MDs distinguishes between physicians and surgeons. During residency, I was trained to be a  who was specializing in general surgery.  Maybe your editors need exsurgeons as proofreaders to catch such terminology in an otherwise excellent editorial; I'm sure that the word physician was used to mean internist, family practitioner, or members of similar specialties. Your slip, though, reminds me of the old vaudeville line—That was no lady; that was my wife!
Aneurysmectomy for Control of Ventricular and Supraventricular Tachyarrhythmias in Patients with Post-infarction or Traumatic Myocardial Aneurysms.
Authors: Lotfy L. Basta
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Aneurysmectomy for Control of Ventricular and Supraventricular Tachyarrhythmias in Patients with Post-infarction or Traumatic Myocardial Aneurysms.Lotfy L. Basta, M.D., Akira Takeshita, M.D., Ernest O. Theilen, M.D., F.A.C.P.Lotfy L. Basta, M.D.Search for more papers by this author, Akira Takeshita, M.D.Search for more papers by this author, Ernest O. Theilen, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-819_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFew patients have been described in whom refractory ventricular tachycardia was controlled by removal of myocardial aneurysms; most of these were postinfarction aneurysms. Of 33 consecutive patients with myocardial aneurysms diagnosed by angiography at the University of lowa Hospital, eight had resistant or recurrent tachyarrhythmias. Aneurysmectomy was performed on six of the eight patients. Three patients were operated on because of refractory tachyarrhythmia alone; the other three were operated on because of congestive heart failure besides the arrhythmia. Four patients survived surgery, with no recurrence of the arrhythmia, for a follow-up period of 5 to 24 months. Of these, one... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: lowa City, Iowa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEncircling endocardial ventriculotomy for refractory ischemic ventricular tachycardiaMechanical factors and the electrocardiogramManagement of patients with malignant ventricular arrhythmias 1 May 1973Volume 78, Issue 5Page: 819-819KeywordsAneurysmsAngiographyArrhythmiaHeart failureSurgeryTachycardiaVentricular tachycardia Issue Published: 1 May 1973 PDF downloadLoading ...
Fungemia with Compromised Host Resistance
Authors: ROBERT C. YOUNG
Journal: Annals of Internal Medicine (1974)

Seventy patients with antemortem fungemia were studied. The findings and subsequent course of the patients allowed these episodes of fungemia to be related to disseminated fungal infection (44 patients), transient catheter-induced fungemia (8 patients), or clinically insignificant fungemia (18 patients). Candida fungemias were associated with disseminated mycosis when the patients were immunosuppressed, leukopenic, grew Candida organisms from three or more other sites, or did not have a contaminated intravenous catheter. Noncandida fungemias were associated with disseminated fungal infection when the patients had multiple other positive sites, grew fungus out of more than one blood culture, and had fungemias with recognized pathogens. Sixty-three percent of the patients had either autopsy-proved or clinically diagnosed disseminated mycoses. Fungemia in patients with compromised host resistance, especially lymphoreticular or hematopoietic malignancies, is frequently associated with disseminated fungal infection.
Medical Student Loans
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Burrage Papers
Authors: Everett R. Spencer
Journal: New England Journal of Medicine (1972)

For years the manuscripts, letters and records relative to the founding of the Massachusetts Medical Society in 1781 and records of subsequent years were stored in whatever boxes and safes were available. Since 1951 the records have been securely (but virtually inaccessible to medical historians) housed in the Society's fire-proof subterranean vault at 22 Fenway in Boston.In the fall of 1971, the records of the Society from 1781 to about 1900 were presented to the Boston Medical Library in the Francis A. Countway Library of Medicine for safekeeping and for possible use as reference material. The transfer of the . . .
Coexistence of Anti-Phospholipid Antibodies and Endothelial Perturbation in Systemic Lupus Erythematosus Patients With Ongoing Prothrombotic State
Authors: Domenico Ferro, Valerio Pittoni, Claudio Quintarelli, Stefania Basili, Mirella Saliola, Costantino Caroselli, Guido Valesini, Francesco Violi
Journal: Circulation (1997)

Background Anti-phospholipid antibodies (aPLs) were associated with an ongoing prothrombotic state in patients with systemic lupus erythematosus (SLE). Because aPLs are able to shift endothelial function toward procoagulant activity in vitro, we investigated the relationship among aPLs, ongoing prothrombotic state, and endothelial perturbation in SLE patients. Methods and Results We measured aPLs, anti-EC antibodies, circulating levels of prothrombin fragment F1+2 (F1+2), tumor necrosis factor-α (TNF-α), tissue-type plasminogen activator (TPA), and von Willebrand factor (vWF) in 43 SLE patients and 25 healthy subjects. Patients positive for aPLs (n=23) had a higher prevalence of anti-EC antibodies ( P =.02) and higher levels of F1+2 ( P =.003) than aPL(−) patients. Endothelial perturbation, defined by elevated plasma levels of both TPA and vWF, was significantly associated with aPL positivity ( P =.001). F1+2 &gt;1 nmol/L (mean+2 SD of controls) was detected in all but one patient in whom aPL positivity and endothelial perturbation coexisted and in no aPL(+) patient without endothelial perturbation ( P =.0039). F1+2 was significantly correlated with vWF (ρ=.6, P =.004) and TPA (114 =.70, P =.0006) only in aPL(+) patients. Endothelial perturbation was closely associated with high values of TNF-α ( P =.0001), anti-phospholipid ( P =.001), and anti-EC antibodies ( P =.012). In 31 patients without a clinical history of thrombosis followed up for 3 years, aPL(+) patients with endothelial perturbation showed higher F1+2 and TNF-α values than aPL(+) patients without endothelial dysfunction. Conclusions This study shows that in SLE patients, aPL positivity is associated with an ongoing prothrombotic state only in the presence of endothelial perturbation. Our findings also suggest that aPLs and TNF-α might cooperate in inducing endothelial perturbation.
T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice.
Authors: D P Hughes, A Hayday, J E Craft, M J Owen, I N Crispe
Journal: The Journal of Experimental Medicine (1995)

Fas-mediated apoptosis is essential for activation-induced cell death of alpha/beta T cells, but it is not clear what role, if any, it plays in regulating other components of the immune system. To study the role of Fas in gamma/delta T cell development, Fas-deficient lpr mice were bred with T cell receptor alpha gene-ablated (TCR-alpha-/-) mice to generate mice deficient in one or both genes. The TCR-alpha-/-, lpr/lpr mice had a nearly 10-fold increase in total lymph node cell (LNC) number compared with Fas-intact TCR-alpha-/- mice, because of expansion of TCR-gamma/delta+ and TCR-beta+ cells. In Fas-intact TCR-alpha-/- mice, approximately one third of the LNCs expressed TCR-gamma/delta. These were evenly divided between the CD4-, CD8-alpha+ and the CD4-, CD8- subsets, and rarely expressed the B220 epitope of CD45. In contrast, in TCR-alpha-/-, lpr/lpr mice, TCR-gamma/delta+ cells comprised half of the LNCs and were primarily CD4-, CD8-, and B220+. Moreover, Fas deficiency in TCR-alpha-/- mice caused a preferential expansion of gamma/delta T cells expressing variable region genes characteristic of intestinal intraepithelial lymphocytes. These results demonstrate a role for Fas in regulating the gamma/delta T cell contribution to peripheral lymph nodes. This mechanism may be most important in limiting the access of activated intestinal intraepithelial lymphocytes to the peripheral lymphoid system.
RELATIONSHIP OF ELECTRICALLY INDUCED PAIN TO THE AMPERAGE AND THE WATTAGE OF SHOCK STIMULI
Authors: Harris E. Hill, Harold G. Flanary, Conan H. Kornetsky, Abraham Wikler
Journal: Journal of Clinical Investigation (1952)

The present paper deals with the development of an apparatus for delivering controlled electric stimuli, and with an attempt to discover which physical aspect of 60 cycle alternating current (voltage, amperage, or wattage) is most closely related to discrimination of shock stimuli in psychological experiments.' Shock, of course, has been the most widely used, and the most  type of noxious stimulus for many psychological studies. However, convenient should be italicized for, while shock is usually rather simple to apply, accurate control of the most effective physical aspect of this stimulus is difficult. A survey of the literature indicates that control of voltage alone in psychological studies is quite unsatisfactory. This is frequently the case even when considerable physical resistance is added to the circuit in series with the biological materials. Problems relating to the use of electric shock stimuli were considered in a round-table discussion of the American Psychological Association (2, 3). Although there was no close agreement among members, the general opinion seemed to be that amperage was the physical aspect of shock which should be controlled. Muenzinger and Walz (4) developed a method for controlling D.C. current (to a great extent) despite variations in skin resistance. This technic has proved quite satisfactory for a number of purposes. However, the few psychophysical experiments that have been performed with control of amperage have yielded disparate results. Thus, Dalziel and Lagen (5) found that the integumental threshold for 60 cycle alternating current was 1.1 milliamperes (ma.), while Forbes and Bernstein (6) found great fluc-
Inhibition of Awake Sympathetic Nerve Activity of Heart Failure Patients With Obstructive Sleep Apnea by Nocturnal Continuous Positive Airway Pressure
Authors: Kengo Usui, T. Douglas Bradley, Jonas Spaak, Clodagh M. Ryan, Toshihiko Kubo, Yasuyuki Kaneko, John S. Floras
Journal: Journal of the American College of Cardiology (2005)
Effect of Prolonged Cold Storage on the Contractile Response of Strips of Rabbit Aorta to Various Agents
Authors: SHOJI SHIBATA, D.D. Timmerman
Journal: Circulation Research (1969)

After 2 days in cold storage (2.0 ± 0.5°C), the contractile response of spiral strips of rabbit aorta to low concentrations (10 -9 to 10 -10 ) of epinephrine and of norepinephrine was potentiated; after storage for 4 to 7 days, an increased contractile response to high concentrations (10 -8 to 10 -6 M) of these catecholamines was also observed. Reserpine-pretreated strips showed potentiation of epinephrine- and norepinephrine-induced contractions, but only after 2 to 7 days in cold storage. Another result of several days of cold storage was a decrease or loss of contractile response to nicotine (10 -5 to 10 -6 M), tyramine (10 -4 to 10 -6 M), and potassium (10 to 40 mM). Potentiation of the contractile response to epinephrine and to norepinephrine was also observed in potassium depolarized strips at low temperature (19°C). After incubation of the depolarized or cold-stored strips in the Ca-free medium, no potentiation of epinephrine- or norepinephrine-induced contractions was observed. These results indicate that cold storage, up to 7 days, does not interfere with the activation system related to epinephrine- or norepinephrine-induced contractions. However, such treatment does affect the membrane system involved in potassium-induced contraction. The decreased response to nicotine and tyramine after several days of cold storage may be due to the unavailability of tissue catecholamine. No significant histopathologic changes were observed in any layer of the aorta after cold storage up to 7 days.
Thomas Woodrow Wilson: A Psychological Study
Authors: Marjorie C. Meehan
Journal: JAMA (1967)

Freud stated that the figure of Woodrow Wilson, "as it rose above the horizon of Europeans, was from the beginning unsympathetic to me and that this aversion increased in the course of years." He did not, however, know him personally. Bullitt knew Wilson from the time of the 1912 presidential campaign, worked under him during the Versailles negotiations, but resigned from the Peace Commission and published an open letter to Wilson in 1919, expressing his disapproval of the terms of the treaty and of Wilson's activity. Freud and Bullitt collaborated over several years to produce a study of Wilson, based largely on information gathered by Bullitt and on psychoanalytic theories expounded by Freud. Understandably, they deferred publication of the book until after the death of Wilson's closest relatives. Freud and Bullitt contend that Wilson's relationship with his father, a Presbyterian minister, formed his character and determined most of the actions
Lack of progress on Calman report criticised
Authors: L. Beecham
Journal: BMJ (1995)

There was frustration at the meeting at the lack of progress in implementing the recommendations in the Calman report on specialist medical training. This was voiced in a motion criticising the dilatory attitude of the government, the General Medical Council, and the royal colleges. Mr David Wrede, a registrar in obstetrics and gynaecology in London, said that they should know how angry junior doctors …
Abstract 4858: Mutant p53 depletion: a possible mechanism of inhibition of human prostate cancer by dietary phenethyl isothiocyanate.
Authors: Lixin Mi, Thomas T.Y. Wang, Haiqiu Huang, Arnetta Fletcher, Lu Yu, Xiantao Wang, Fung-Lung Chung
Journal: Cancer Research (2013)

Abstract Phenethyl isothiocyanate (PEITC) derived from cruciferous vegetables has been shown to inhibit tumor growth by induction of apoptosis. Previously, we demonstrated that PEITC can selectively deplete mutant p53, but not the wild type. However, whether p53, wild type or mutant, plays functional roles in PEITC-induced growth inhibition, remains unsettled. We hypothesize that the direct binding to mutant p53 by PEITC followed by conformational changes, subsequently leading to its depletion or/and restoration to the wild type may constitute a mechanism by which PEITC induces apoptosis. To determine whether PEITC can deplete mutant p53 in vivo and whether its depletion is correlated with tumor inhibition and apoptosis, in this xenograft model study BALB-C Nu/Nu mice carrying prostate tumor cells with either mutant (DU145) or wild type p53 (LNCap) were fed diets with and without PEITC (5 micromol per gram diet) for 8 weeks. Tumors were harvested at the end of bioassay for immunohistochemistry and immunoblot studies. Results showed that the tumor volumes of both LNCap and DU145 were significantly decreased in the PEITC-treated animals, compared with that on a diet without PEITC. The p53 level detected by immunoblot showed a moderate, yet significant, decrease in DU145 tumors, but not in LNCap tumors. Immunohistochemistry assays were carried out to examine the apoptotic markers, such as TUNEL, and anti-proliferation marker Ki67 in tumors from the PEITC-treated vs. untreated mice. This study provides the first in vivo evidence that mutant p53 can be depleted in tumors of mice fed PEITC-containing diet and its depletion seems to correlate with growth inhibition in the mutant p53 tumors. These findings suggest that mutant p53 maybe further investigated as a possible novel target for cancer chemoprevention and therapy by PEITC. (Supported by NCI grant CA100853) Citation Format: Lixin Mi, Thomas T.Y. Wang, Haiqiu Huang, Arnetta Fletcher, Lu Yu, Xiantao Wang, Fung-Lung Chung. Mutant p53 depletion: a possible mechanism of inhibition of human prostate cancer by dietary phenethyl isothiocyanate. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4858. doi:10.1158/1538-7445.AM2013-4858
Acute fulminating amoebic colitis: survival after total colectomy.
Authors: R R Babb, M L Trollope
Journal: Gut (1985)

Acute fulminating amoebic colitis is a very uncommon complication of amoebiasis. Most patients die, with or without surgery. We report such a patient who survived after total colectomy. If an excision of diseased colon is done, an exteriorising procedure should be added and primary anastomosis avoided.