tbuckley/cabot-search huggingface dataset:
Diagnosing Lumbar Spinal Stenosis—Reply
Authors: Andrew J. Haig
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Organ donation after paracetamol overdose.
Authors: S Jackson, P Nightingale, M P Shelly
Journal: BMJ (1993)

among the 119 recorded as dying in 1990 or how many would not have taken an overdose had they been aware that paracetamol, if taken in large quantities, often results in a painful and lingering death due to liver failure.By diverting attention towards the 1143 deaths due to overdose of drugs other than paracetamol Spooner disregards the fact that paracetamol is consistently one of the most common drugs used in suicide and far exceeds any other over the counter medication as a method of death by poisoning.It is also by far the most common substance used in deliberate self poisoning attempts.In a review of 3263 admissions after deliberate self poisoning in South West Thames region in 1989 I found that 957 were a result of paracetamol overdose (unpublished study).The next most common class of drugs used was benzodiazepines, which accounted for 584 admissions.Benzodiazepines, of course, are prescription only drugs, and an overdose is far less likely to cause death.Combining paracetamol with methionine, as Bray suggests, may not be the answer, but surely the manufacturers of paracetamol should take a more responsible attitude by at least placing a more specific warning of the effects of overdose on the packaging.
Expression and mutation status of candidate kinases in multiple myeloma
Authors: J O Claudio, F Zhan, L Zhuang, R Khaja, Y X Zhu, K Sivananthan, S Trudel, E Masih-Khan, R Fonseca, P L Bergsagel, S W Scherer, J Shaughnessy, A K Stewart
Journal: Leukemia (2007)
Dose Escalation of Carmustine in Surgically Implanted Polymers in Patients With Recurrent Malignant Glioma: A New Approaches to Brain Tumor Therapy CNS Consortium Trial
Authors: Alessandro Olivi, Stuart A. Grossman, Stephen Tatter, Fred Barker, Kevin Judy, Jeffrey Olsen, Jeffrey Bruce, Dana Hilt, Joy Fisher, Steve Piantadosi
Journal: Journal of Clinical Oncology (2003)

This New Approaches to Brain Tumor Therapy CNS Consortium study sought to determine the maximum-tolerated dose (MTD) of carmustine (BCNU) that can be implanted in biodegradable polymers following resection of recurrent high-grade gliomas and the systemic BCNU exposure with increasing doses of interstitial BCNU.Forty-four adults underwent tumor debulking and polymer placement. Six patients per dose level were studied using polymers with 6.5%, 10%, 14.5%, 20%, and 28% BCNU by weight. Toxicities were assessed 1 month after implantation by a safety monitoring committee to determine whether subsequent escalations should occur. Nine additional patients were studied at the MTD to confirm safety. BCNU blood levels were obtained before and after polymer implantation.No dose-limiting toxicities were identified at the 6.5%, 10%, or 14.5% dose levels, although difficulties with wound healing, seizures, and brain edema were noted. At the 20% dose, these effects seemed more prominent, and six additional patients were treated at this dose and tolerated treatment well. Three of four patients receiving the 28% polymers developed severe brain edema and seizures, and accrual to this cohort was stopped. Nine additional patients received 20% polymer, confirming this as the MTD. Maximum BCNU plasma concentrations with the 20% loaded polymers were 27 ng/mL. Overall median survival was 251 days.The MTD of BCNU delivered in polymer to the surgical cavity is 20%. This polymer provides five times more BCNU than standard commercially available BCNU polymers and results in minimal systemic BCNU exposure. Additional studies are needed to establish the efficacy of high-dose BCNU polymers.
Dilatation of Cerebral Arterioles in Response to Activation of Adenylate Cyclase Is Dependent on Activation of Ca <sup>2+</sup> -Dependent K <sup>+</sup> Channels
Authors: Hisao Taguchi, Donald D. Heistad, Takanari Kitazono, Frank M. Faraci
Journal: Circulation Research (1995)

Abstract The role of Ca 2+ -dependent potassium channels in mediating vascular responses to activation of adenylate cyclase in vivo is not known. The goal of this study was to examine the hypothesis that dilatation of cerebral arterioles in response to activation of adenylate cyclase is mediated by activation of Ca 2+ -dependent potassium channels. Diameters of cerebral arterioles were measured in vivo in anesthetized rabbits. Topical application of forskolin (1 and 10 μmol/L), a direct activator of adenylate cyclase, dilated cerebral arterioles by 40±8% (mean±SEM) and 71±9%, respectively, from a control diameter of 85±4 μm. Iberiotoxin (50 and 100 nmol/L), a selective inhibitor of Ca 2+ -dependent potassium channels, inhibited dilatation in response to both concentrations of forskolin by 45% to 60%. We obtained similar results by using charybdotoxin (50 nmol/L), another inhibitor of Ca 2+ -dependent potassium channels. Vasodilatation in response to dibutyryl cAMP (a cell-permeable cAMP analogue) was also inhibited by iberiotoxin. In contrast, dilatation of cerebral arterioles in response to sodium nitroprusside and acetylcholine (activators of guanylate cyclase) and aprikalim (activator of ATP-sensitive potassium channels) was not inhibited by iberiotoxin. These findings suggest that dilatation of cerebral arterioles in response to forskolin and increases in intracellular concentrations of cAMP are mediated by activation of Ca 2+ -dependent potassium channels. Thus, activation of Ca 2+ -dependent potassium channels may be a major mechanism of cerebral vasodilatation in response to activation of adenylate cyclase in vivo.
Hexachlorophane--yes or no?
Authors: J M Gowdy
Journal: BMJ (1977)

<h3>Abstract</h3> Motor neurons (MNs) innervating the digit muscles of the intrinsic hand (IH) and intrinsic foot (IF) control fine motor movements. The ability to reproducibly label specifically IH and IF MNs in mice would be a beneficial tool for studies focused on fine motor control. To this end, we find that a CRE knock-in mouse line of <i>Atoh1</i>, a developmentally expressed basic helix-loop-helix (bHLH) transcription factor, reliably expresses CRE-dependent reporter genes in ∼60% of the IH and IF MNs. We determine that CRE-dependent expression in IH and IF MNs is ectopic because an <i>Atoh1</i> mouse line driving FLPo recombinase does not label these MNs although other <i>Atoh1</i>-lineage neurons in the intermediate spinal cord are reliably identified. Furthermore, the CRE-dependent reporter expression is enriched in the IH and IF MN pools with much sparser labeling of other limb-innervating MN pools such as the tibialis anterior (TA), gastrocnemius (GS), quadricep (Q), and adductor (Ad). Lastly, we find that ectopic reporter expression begins postnatally and labels a mixture of α and γ-MNs. Altogether, the <i>Atoh1</i> CRE knock-in mouse strain might be a useful tool to explore the function and connectivity of MNs involved in fine motor control when combined with other genetic or viral strategies that can restrict labeling specifically to the IH and IF MNs. Accordingly, we provide an example of sparse labeling of IH and IF MNs using an intersectional genetic approach.
Long-term biological response of injured rat carotid artery seeded with smooth muscle cells expressing retrovirally introduced human genes.
Authors: M M Clowes, C M Lynch, A D Miller, D G Miller, W R Osborne, A W Clowes
Journal: Journal of Clinical Investigation (1994)

Cultured vascular smooth muscle cells (SMCs) containing retrovirally introduced genes are a potential vehicle for gene replacement therapy. Because the cultured SMCs are selected for their ability to proliferate in vitro, it is possible that the SMCs might be permanently altered and lose their capacity to respond to growth-suppressing conditions after being seeded back into blood vessels. To investigate this possibility we measured SMC proliferation and intimal thickening in balloon-injured Fischer 344 rat carotid arteries seeded with SMCs stained with the fluorescent marker 1,1'-dioctadecyl-3,3,3',3'-tetramethylindo-carbocyanine perchlorate (DiI) and infected with replication-defective retrovirus expressing human adenosine deaminase or human placental alkaline phosphatase. The majority of the seeded SMCs remained in the intima while a few of the cells appeared to migrate into the first layer of the media. Intimal SMC proliferation returned to background levels (< 0.1% thymidine labeling index) by 28 d. At late times (1 and 12 mo) the morphological appearance of the intima was the same for balloon-injured arteries with or without seeded SMC, except that the seeded arteries continued to express human adenosine deaminase or alkaline phosphatase. These results support the conclusion that cultured SMC infected with a replication-defective virus containing human adenosine deaminase or alkaline phosphatase are not phenotypically altered and do not become transformed. After seeding onto the surface of an injured artery, they stop replicating but continue to express the introduced human genes even over the long term.
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
Authors: R.F. Clark, M. Hutton, M. Fuldner, S. Froelich, E. Karran, C. Talbot, R. Crook, C. Lendon, G. Prihar, C. He, K. Korenblat, A. Martinez, M. Wragg, F. Busfield, M.I. Behrens, A. Myers, J. Norton, J. Morris, N. Mehta, C. Pearson, S. Lincoln, M. Baker, K. Duff, C. Zehr, J. Perez-Tur, H. Houlden, A. Ruiz, J. Ossa, F. Lopera, M. Arcos, L. Madrigal, J. Collinge, C. Humphreys, A. Ashworth, S. Sarner, N. Fox, R. Harvey, A. Kennedy, P. Roques, R.T. Cline, C.A. Philips, J.C. Venter, L. Forsell, K. Axelman, L. Lilius, J. Johnston, R. Cowburn, M. Viitanen, B. Winblad, K. Kosik, M. Haltia, M. Poyhonen, D. Dickson, D. Mann, D. Neary, J. Snowden, P. Lantos, L. Lannfelt, M. Rossor, G.W. Roberts, M.D. Adams, J. Hardy, A. Goate
Journal: Nature Genetics (1995)
Onychomycosis and linear nail growth
Authors: V. Goulden, M.J.D. Goodfield
Journal: British Journal of Dermatology (1997)

Journal Article Onychomycosis and linear nail growth Get access V. Goulden, V. Goulden Dermatology Department. Leeds General Infirmary leeds U.K. Search for other works by this author on: Oxford Academic Google Scholar M.J.D. Goodfield M.J.D. Goodfield Dermatology Department. Leeds General Infirmary leeds U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 1, 1 January 1997, Pages 139–140, https://doi.org/10.1111/j.1365-2133.1997.tb08772.x Published: 01 January 1997
Submandibular Salivary Gland Transfer
Authors: William Makis, Anthony Ciarallo, Gad Abikhzer, Christopher Rush, Jerome Laufer, Jerry Stern
Journal: Clinical Nuclear Medicine (2011)

Xerostomia is a significant morbidity of radiation treatment in the management of head and neck cancers. To preserve salivary function, a surgical technique has been developed that involves the transfer of one submandibular gland to the ipsilateral submental space, where it can be shielded during radiation therapy. F-18 FDG PET/CT imaging characteristics of recently or remotely transferred submandibular glands have not been previously described in the literature. We report 2 cases of patients with surgically transferred submandibular glands, which highlight a potential pitfall in the interpretation of PET/CT of the head and neck region in oncologic patients.
DNA on Trial
Authors: Paul R. Billings
Journal: New England Journal of Medicine (1995)

To the Editor: Professor Housman's article (Feb. 23 issue)1 succinctly covers many of the issues in the use of DNA typing in forensic settings. The movement of this method from research contexts to courtrooms has been rapid and controversial and has engendered misunderstanding. For example, prosecutors and judges have mistaken the probability of a sample match for the probability of guilt in presentations to juries. This so-called prosecutor's fallacy has led to convictions being overturned by higher courts.
II. Principles of a Program to Foster Family Practice
Authors: John S. DeTar
Journal: JAMA (1961)

FIFTY YEARS ago no one ever asked which doctor was the family physician, because everyone knew it was the general practitioner. Twenty-five years ago the same answer was given, but with some reservations. Ten years ago the doubters were questioning openly, and today it is a matter of real concern not only to generalists, internists, and pediatricians, but to medical educators whose responsibility it is to provide adequate training for those who will assume this important function in American life during the next decade. The House of Delegates of the American Medical Association has debated the problems of general practice for many sessions. The American Academy of General Practice is intensely interested. This Congress on Medical Education has discussed it. In fact, it was on the floor of this congress, just 4 years ago that Dr. Dana W. Atchley of the Columbia-Presbyterian Medical Center quoted a framed statement which hangs
Detecting left main coronary artery disease by apical, cross-sectional echocardiography.
Authors: C C Chen, J Morganroth, S Ogawa, T J Mardelli
Journal: Circulation (1980)

To test the feasibility of imaging the left main coronary artery (LMCA) noninvasively as a means of detecting left main coronary artery disease, we studied 73 patients who underwent cardiac catheterization and cross-sectional echocardiography. Fifty-two had a normal LMCA (controls) and 21 had significant obstruction (greater than or equal to 50% luminal reduction). The apical, tomographic, cross-sectional, phased-array, echocardiographic approach was used, and the LMCA was imaged in 52 of 73 patients (71%). In 34 of 36 controls (94%) the LMCA was correctly judged as having no luminal obstruction. In the other two, and asymmetric, high-intensity echo in one wall of the artery suggested atherosclerotic disease, but coronary angiography revealed no obstruction. In 12 of 16 patients (75%) in whom significant LMCA disease was imaged, obstruction was predicted by echocardiographic criteria of either luminal irregularity or an asymmetric, high-intensity echo in the arterial wall. This preliminary study suggests that cross-sectional echocardiography appears to be a feasible, noninvasive technique to image the LMCA and to detect hemodynamically significant luminal obstruction.
Abstract B68: Chemomodulatory potential of aloe vera gel on DMBA-induced skin papillomagenesis, drug metabolizing and antioxidant enzymes
Authors: M. Singh, S. Singh, R. K. Kale
Journal: Cancer Research (2011)

Abstract Aloe vera has traditionally been used as a folk medicine around the world. Therefore, we evaluated the chemopreventive potential of A. Vera on cell proliferation and apoptosis in DMBA induced skin papillomagenesis in mice, using three different concentrations as well as its influence on phase-I, phase-II and antioxidant enzymes, glutathione content, lactate dehydrogenase and peroxidative damage in the liver of the mice. DMBA and croton oil was used to induce and promote skin papillomagenesis respectively. Skin papillomagenesis study was done by giving three different doses of A. vera [low dose 1:3 dilution, mid dose 1:1 dilution and high dose 1:0 dilution] to mice till termination of the experiment. Using relatively effective dose [1:1 dilution] of A. vera, its chemopreventive potential was examined at pre-initiational, peri-initiational, post-initiational and promotional stage in terms of tumor incidences and tumor multiplicity. In addition, the expression of cell proliferation, glutathione-S-transferase, and apoptosis were analyzed in the skin tumors by immunohistochemical study. For biochemical studies, mice were given with the same doses of A. Vera gel in drinking water for two weeks. Results showed a significant reduction in the skin tumors (upto 42%) in A. vera gel treated animals, as compared to the control group of animals. A. vera was found to be more effective in inhibiting the tumor multiplicity (upto 72 %) compared to the tumor incidence (30 %). Relative to control (100 %), the tumor incidence were 77 %, 80 %, 92 % and 54% in case of pre-initiational, peri-initiational, post-initiational and promotional treatment of A. Vera gel respectively. Since A. Vera inhibited phase-I enzyme system and enhanced phase-II enzyme system, it could be considered as dual acting chemopreventive agent. Increased antioxidant enzyme system and decreased peroxidation damage suggestive of its potential to enhance the antioxidant status of animals which might contribute to chemopreventive property. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr B68.
T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy
Authors: Elaine M. Sloand, J. Joseph Melenhorst, Zachary C. G. Tucker, Loretta Pfannes, Jason M. Brenchley, Agnes Yong, Valeria Visconte, Colin Wu, Emma Gostick, Phillip Scheinberg, Matthew J. Olnes, Daniel C. Douek, David A. Price, A. John Barrett, Neal S. Young
Journal: Blood (2010)
The Health Policy Election
Authors: Aaron E. Carroll, Austin B. Frakt
Journal: JAMA (2012)

MUCH IS AT STAKE IN THE 2012 PRESIDENTIAL ELECtion. President Barack Obama’s vision and former Governor Mitt Romney’s vision differ across many domains, but perhaps most starkly in the area of health policy. Fundamentally, the candidates disagree on the role of government as the guarantor of affordable access to health insurance, as evidenced by their plans for private insurance markets, Medicare, and Medicaid.
Radioimmunoassay Measurement of Prostaglandins E, A, and F in Human Plasma
Authors: Bernard M. Jaffe, Harold R. Behrman, Charles W. Parker
Journal: Journal of Clinical Investigation (1973)

The details of a radioimmunoassay capable of measuring as 5 pg of prostaglandin A, E, and F (PGA, PGE, and PGF) in human and rat plasma are described. Plasma samples are extracted (with 4000 cpm [(3)H] PGE(1) added for calculation of recovery) with an organic solvent system at an apparent pH of 5.8 and then chromatographed on silicic acid columns with increasing concentrations of methanol to separate PGA, PGE, and PGF. Each chromatographed sample is measured by radioimmunoassay, using the homologous antibody and tritiated marker. 40 normal individuals had mean plasma concentrations of PGA, PGE, and PGF of 1062+/-107 pg/ml, 385+/-30 pg/ml, and 141+/-15 pg/ml, respectively. Elevated PGE levels were measured in the plasma of patients with medullary carcinoma of the thyroid, carcinoid, and neuroblastoma. Treatment of rats with indomethacin decreased serum PGE levels by 67%. The radioimmunoassay appears to be of considerable experimental as well as clinical interest.
"My baby keeps bringing up his feeds!"
Authors: J. Banerjee, M. M. Roy, S. Bhojani, N. Emcy
Journal: BMJ (2010)

A 6 week old baby boy, first child of young white parents, presents with recurrent episodes of vomiting from age 3 weeks. He was born at term after an uneventful pregnancy. This presentation is common and generally falls into one of three categories:
Rhabdomyolysis and Renal Failure
Authors: MARK D. FISCHER
Journal: Annals of Internal Medicine (1976)

Comments1 October 1976Rhabdomyolysis and Renal FailureMARK D. FISCHER, M.D., HIBBARD E. WILLIAMS, M.D.MARK D. FISCHER, M.D.Search for more papers by this author, HIBBARD E. WILLIAMS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-4-537_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In light of the patient population at San Francisco General Hospital, we read with interest the recent article on renal failure and rhabdomyolysis by Koffl;er, Friedler, and Massry (Ann Intern Med85:23-28, 1976). The magnitude of hyperuricemia is an aspect of this syndrome we have seen in several patients. The mechanism postulated by the authors for the elevated serum level, that is, "increased liberation of adenine nucleotides by muscle," is plausible in view of a concomitant 24-h hyperuricosuria in patients with heat stress, exercise, and muscle injury as described by Knochel, Dotin, and Hamburger (1). Elevated urinary...References1. KNOCHELDOTLINHAMBURGER JLR: Heat stress, exercise, and muscle injury: effects on urate metabolism and renal function. Ann Intern Med 81:321-328, 1974 LinkGoogle Scholar2. LECOCQMCPHAUL FJ: The effects of starvation, high fat diets, and ketone infusions on uric acid balance. Metabolism 14:186-197, 1965 CrossrefMedlineGoogle Scholar3. STEELE T: Control of uric acid excretion. N Engl J Med 284:1193-1196, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical Service San Francisco General Hospital and Department of Medicine University of California San Francisco, CA 94110 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1976Volume 85, Issue 4Page: 537-537KeywordsAdenineExerciseMusclesNucleotidesRenal failureRhabdomyolysis Issue Published: 1 October 1976 PDF DownloadLoading ...