tbuckley/cabot-search huggingface dataset:
Abstract P6-13-03: Local Treatment Strategies in Young and Elderly Stage IV Breast Cancer Patients in the USA and The Netherlands
Authors: W van de Water, E Bastiaannet, S van de Velde, OM Dekkers, JA Margenthaler, AD Deshpande, DB Jeffe, AJM de Craen, CJH van de Velde, GJ. Liefers
Journal: Cancer Research (2010)

Abstract Introduction Approximately 5-10% of breast cancer patients present with stage IV at diagnosis. The appropriate treatment is still under debate. This study focused on differences in treatment regimens between the United States (USA) and the Netherlands (NL) within age groups. Methods As we included data from NL and the USA, we were able to construct an instrumental variable as a substitute for randomization and get around selection bias. We compared Dutch and USA treatment strategies; restrictive versus more often extensive local therapy. Data from the NL Cancer Registry and the US Survaillance, Epidemiology and End Results Program were used to construct a database for analyses. All primary stage IV breast cancer patients diagnosed in 1995-2003 were included. Follow up cutoff date was 12- 31-2005 (USA) and 12-31-2008 (NL). Analyses were stratified by age (&amp;lt;65, 65-75 and ≥75 years). Chi Square Tests were performed for therapy rates, overall survival was calculated by Cox Proportional Hazard Analyses. Results A total number of 11030 patients were included (5354 NL, 5676 USA). Within each age category, surgery was applied more often in the USA (&amp;lt;65: NL37%-USA52%, P&amp;lt;0.001. 65-75: NL28%-USA42%, P&amp;lt;0.001. ≥75: NL21%-USA39%, P&amp;lt;0.001). Similar results were observed for use of radiotherapy after surgery (&amp;lt;65: NL30%-USA47%, P&amp;lt;0.001. 65-75: NL26%-USA44%, P&amp;lt;0.001. ≥75: NL 17%-USA36%, P&amp;lt;0.001). Rate of radiotherapy without surgery did not differ between the two countries. With increasing age, use of surgery and use of radiotherapy after surgical treatment decreased (NL, USA each P&amp;lt;0.001). Use of radiotherapy without surgical intervention however increased with age in both countries (NL p=0.002, USA p=0.001). Although unadjusted analysis showed enhanced overall survival for patients &amp;lt;65 years of age in the USA compared to NL (HR 0.92 (0.86-0.98), p=0.006), these results were not confirmed in multivariable analyses. Patients ≥75 years of age in the USA compared to NL, however, had worse overall survival, confirmed in multivariable analyses (HR 1.17 (1.08-1.27), P&amp;lt;0.001). Conclusion Surgery and radiotherapy after surgical treatment for stage IV breast cancer patients was applied more often in the USA compared to NL in all age categories. Use of local therapy decreased with increasing age. In multivariable analyses, patients ≥75 years of age had a worse overall survival in the USA. This finding suggests that a more extensive local treatment strategy does not improve overall survival in this group of elderly patients. The opposite was true for young patients, although these results were not confirmed in multivariable analyses. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-13-03.
275 ADAM10, ADAM17 AND MMP2 ACTIVITIES IN HEPATIC STELLATE CELLS ARE INVOLVED IN CX3CL1 PROCESSING AND CONTRIBUTE TO CHRONIC LIVER INJURY
Authors: K. Bourd-Boittin, L. Basset, D. Bonnier, A. L'Helgoualc'h, M. Samson, N. Theret
Journal: Journal of Hepatology (2009)
Abstract 3434: Incidence and Characteristics of Coronary Aneurysm after Drug-eluting Stent Implantation
Authors: Seung-Woon Rha, Sunil P Wani, Cheol Ung Choi, Soon Yong Suh, Eung Ju Kim, Jin Won Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Circulation (2006)

Background:  Drug-eluting stents (DES) may induce toxic effects on the coronary arterial wall such as aneurysm formation, incomplete stent apposition, stent thrombosis and vessel rupture based on the experimental studies. We investigated the incidence and characteristics of arteriopathy at 6 month routine angiographic follow up after DES implantation regardless of clinical events in a single center unrestricted DES registry.   Methods:  A total 614 consecutive patients (pts ,  Male 278, mean age 63.12±10.89 years) who were treated with DES (Sirolimus-SES and/or Paclitaxel-PES) were enrolled. We performed routine angiographic follow up at 6 months regardless of clinical events and IVUS was done in case of angiographic aneurismal change at the DES implanted site was observed.   Results:  Conventional coronary risk factors were not different compared with control study population. The incidence of coronary aneurysm was 3.1 % (19/614). Among the 19 coronary aneurysm patients (pts, Male 16, Age 61.68± 10.37years), 20 lesions treated with SES and 10 PES (Mean diameter and length 3.05 ± 0.38; 24.1 ± 5.5 mm respectively ) to cover 16 left anterior descending arteries, 1 left main, 4 circumflex and 9 right coronary artery (Type C lesions, 80%). Ten pts had single aneurysm (mean diameter 2.66 mm) and 9 multiple aneurysms (mean number 2.5, mean diameter 4.46 mm). There were 2 aneurysms developed at the edge of SES and 1 at PES. The biggest aneurysm was seen in the PES (diameter 9.7 mm). IVUS demonstrated focal lack of contact between DES and coronary vessel wall without malapposition in all pts. Most of the pts were asymptomatic (no fever or allergic complaints) with no clinical events up to 6 months.   Conclusion:  The incidence of aneurysm formation after DES implantation in a real world DES registry at 6 months was 3.1%. The DES-related aneurysm appears to be associated with the use of SES and mainly developed in the body of the DES. The cytotoxic effects of the drug seem to be responsible for development of DES-related aneurysm. Although the aneurysms were relatively larger and multiple in half of the pts, but were not associated with clinical events including stent thrombosis or rupture.
18F–FLUORIDE UPTAKE AS A NOVEL BIOMARKER OF CORONARY PLAQUE RUPTURE
Authors: Nikhil Vilas Joshi, Su Ern Yeoh, Michelle Williams, Miles Behan, Alison Fletcher, Nicholas Cruden, Nicholas Mills, Patrick A. Calvert, Edwin JR van Beek, Neal Uren, Daniel Berman, James Rudd, Marc Dweck, David Newby
Journal: Journal of the American College of Cardiology (2013)
Responses of the cerebral circulation to hypercapnia and hypoxia after 7th cranial nerve transection in baboons.
Authors: J T Hoff, E T MacKenzie, A M Harper
Journal: Circulation Research (1977)

It has been proposed that the responses of the cerebral circulation to hypoxia, hypercapnia and hypotension may be partially mediated by an autonomic reflex with receptors in the carotid body or sinus serving as sensors and the efferent limbs being the 7th cranial nerves. Transection of the 7th cranial nerve has been reported to impair the cerebral circulatory response to isolated chemoreceptor stimulation by hypoxia and hypercapnia. To test this hypothesis we measured cerebral blood flow (CBF) by an intra-arterial 133Xe technique in 10 baboons during periods of induced hypoxia and hypercapnia, both before and after transection of the 7th cranial nerve, We found that the responses of CBF were unaltered by either unilateral or bilateral section of the nerve. Our results showing the preservation of normal CBF responses, following transection, suggest that neurogenic control of the cerebral circulation by an autonomic reflex involving the 7th nerve is unlikely.
THE RELATIONSHIP BETWEEN HIGH ON-TREATMENT PLATELET REACTIVITY AND RAPID ANGIOGRAPHIC PROGRESSION OF NON-CULPRIT CORONARY LESIONS IN PATIENTS WITH ACUTE CORONARY SYNDROMES
Authors: Kengo Tsukahara, Kazuo Kimura, Toshiaki Ebina, Masami Kosuge, Kiyoshi Hibi, Noriaki Iwahashi, Mitsuaki Endo, Nobuhiko Maejima, Satoshi Umemura
Journal: Journal of the American College of Cardiology (2011)
Evidence for intestinal origin of transcobalamin II during vitamin B12 absorption.
Authors: I Chanarin, M Muir, A Hughes, A V Hoffbrand
Journal: BMJ (1978)

The plasma binding of newly absorbed, radioactively labelled vitamin B12 was studied during a urinary excretion (Schilling) test. Vitamin B12, after being absorbed from the gut, enters blood attached to transcobalamin II, which seems to be derived from the ileal enterocyte. The absorbed B12 re-enters the blood stream after the transcobalamin II-B12 complex is cleared by the liver and it is then excreted into the urine during the Schilling test.
Cytoplasmic Antigen in Hepatocytes of Chimpanzees Infected With Non–A, Non–B Hepatitis Virus or Hepatitis Delta Virus: Relationship to Interferon
Authors: Yohko K. Shimizu, Robert H. Purcell
Journal: Hepatology (1989)

We previously described a cytoplasmic antigen, detected by monoclonal antibodies, in hepatocytes of chimpanzees experimentally infected with the parenterally transmitted form of non-A, non-B hepatitis virus or with the hepatitis delta virus. The expression of this antigen appears to be a host-specified response to infection with these two hepatitis viruses but not with hepatitis A virus, hepatitis B virus or enterically transmitted non-A, non-B hepatitis virus. To determine whether this antigen, found in parallel with the hepatocyte cytoplasmic structures described previously, is associated with interferon, as suggested by others, we studied by immunofluorescence liver biopsies from chimpanzees treated with an interferon inducer or exogenous interferon for the presence of the antigen. In two hepatitis B virus carrier chimpanzees and one normal chimpanzee treated with the interferon inducer polyinosinic-polyribocytidylic acid-poly-l-lysine carboxymethylcellulose, the antigen became detectable in hepatocytes within 2 weeks of initiation of the treatment, remained detectable throughout the treatment and disappeared within 4 weeks after treatment was terminated. Electron microscopy revealed that the biopsies positive for the antigen exhibited the hepatocyte cytoplasmic changes; convoluted membranes and microtubular aggregates, identical to those described originally for chimpanzees infected with non-A, non-B hepatitis virus. The antigen was not detected in any of the biopsies from a control chimpanzee that received only the carboxymethylcellulose used to stabilize the interferon inducer. In addition, liver biopsies obtained from a hepatitis B virus carrier chimpanzee during treatment with exogenous human leukocyte interferon were found to be positive for the antigen as well.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLE ON DENTITION.
Authors: A. H. GOOD
Journal: JAMA (1883)

Read in the Section on Diseases of Children, June, 1883. Mr. President, and Gentlemen of the American Medical Association: The process of dentition is not properly classed as a disease, but the diseases which accompany it are numerous; hence I have given my paper the nomenclature Dentition. In order to be brief, I will not refer to statistics. In dentition, with its accompanying diseases, the mortality is generally greater than in all other diseases to which children are subjected. Some children are more easily disturbed by teething than others, because cause of not being so strongly organized, or because of some peculiar susceptibility to its infiuence. I conceive it to be true that the process of dentition acts more severely (although a natural one) than would foreign bodies similarly located. At the extremity of each tooth-root is the dental foramen through which the dental nerve passes, and during the growth
Aspergillus Vertebral Osteomyelitis in a Child with a Primary Monocyte Killing Defect: Response to GM-CSF Therapy
Authors: L. Abu Jawdeh, R. Haidar, F. Bitar, S. Mroueh, S. Akel, N. Nuwayri-Salti, G.S. Dbaibo
Journal: Journal of Infection (2000)
Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated?
Authors: R D Rosenberg, N W Shworak, J Liu, J J Schwartz, L Zhang
Journal: Journal of Clinical Investigation (1997)

2-O -sulfated glucuronic acid; GlcNAc, N -acetylglucosamine; GlcN(Ac/S), N -acetyl
Cerebritis in Lupus Erythematosus
Authors: JAMES S. GOODWIN
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 March 1979Cerebritis in Lupus ErythematosusJAMES S. GOODWIN, M.D., JEAN M. GOODWIN, M.D.JAMES S. GOODWIN, M.D.Search for more papers by this author, JEAN M. GOODWIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-437 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The most common neurologic manifestation of systemic lupus erythematosus is organic brain disease, which occurs in about 20% of patients (1). This high incidence of organic brain disease has been thought to be the result of episodes of cerebral vasculitis. We show here that scores of mental status testing in patients with lupus erythematosus decrease as a function of disease duration but are not related to whether the patient had a previous episode of clinical cerebritis. This would suggest that a chronic subclinical cerebritis might occur in many patients with lupus erythematosus.We have studied 22 patients...References1. GANZGURLANDDEMINGFISHER VBWB: The study of the psychiatric symptoms of systemic lupus erythematosus. Psychosom Med 34:207-220, 1972 CrossrefMedlineGoogle Scholar2. JACOBSBERNHARDDELGADOSTRAIN JMAJ: Screening for organic mental syndromes in the medically ill. Ann Intern Med 86:40-46, 1977 LinkGoogle Scholar3. PINCHINGTRAVERSHUGHESJONESMOSS ARGTS: Oxygen-15 brain scanning for detection of cerebral involvement in systemic lupus erythematosus. Lancet 1:898-900, 1978 CrossrefMedlineGoogle Scholar4. GLASER G: Lesions of central nervous system in disseminated lupus erythematosus. Arch Neurol Psychiatry 67:745-753, 1952 CrossrefGoogle Scholar5. KNIGHTSFOLSTEIN EM: Unsuspected emotional and cognitive disturbance in medical patients. Ann Intern Med 87:723-724, 1977 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES S. GOODWIN, M.D.; JEAN M. GOODWIN, M.D.Affiliations: University of New Mexico School of Medicine Albuquerque, NM 87131 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeuropsychiatric Manifestations of Systemic Lupus Erythematosus1. Neuropsychiatric Lupus ErythematosusNeuropsychiatric manifestations of systemic lupus erythematosusManifestations neuropsychiatriques du lupus érythémateux disséminéNeuropsychiatric Manifestations of Systemic Lupus ErythematosusOutcome and Prognosis in Systemic Lupus ErythematosusSLE retinopathy: evaluation by fluorescein angiography. 1 March 1979Volume 90, Issue 3Page: 437-438KeywordsBrain diseasesLupus erythematosusPatientsVasculitis ePublished: 1 December 2008 Issue Published: 1 March 1979 PDF downloadLoading ...
The hepatopulmonary syndrome: new name, old complexities.
Authors: R Rodriguez-Roisin, A G Agusti, J Roca
Journal: Thorax (1992)

On the basis of previous work, our own experience and findings, and the considerations discussed above, we propose a set of four diagnostic criteria for the hepatopulmonary syndrome: 1. presence of chronic hepatic disease (alcoholic, postnecrotic, or primary biliary cirrhosis or active chronic hepatitis)--severe liver dysfunction may not be mandatory; 2. absence of intrinsic cardiopulmonary disease, with normal chest radiograph or with nodular basal shadowing; 3. pulmonary gas exchange abnormalities--an increased alveolar-arterial oxygen gradient (&gt; or = 2.0 kPa) with or without hypoxaemia; 4. the extrapulmonary appearance of intravenous radiolabelled microspheres or a positive contrast enhanced echocardiogram, suggesting intrapulmonary vascular abnormalities. Although these four criteria appear straightforward, there may be other features that are not always present--namely: 1. low transfer factor (diffusing capacity); 2. shortness of breath, with or without platypnoea and orthodeoxia; 3. increased cardiac output and reduced pulmonary vascular pressures; 4. small (or no) increase in pulmonary vascular resistance when the patient is breathing low oxygen mixtures. From the physiological viewpoint, the hepatopulmonary syndrome provides an excellent model for clinical research in the pathophysiology of pulmonary gas exchange. So far it has been possible to show that arterial hypoxaemia in this condition is (1) partitioned into components resulting from VA/Q mismatching, intrapulmonary shunt, and limitations of oxygen diffusion; (2) modulated by the interplay between the intrapulmonary and the extrapulmonary determinants of PaO2, such as cardiac output and minute ventilation; (3) vulnerable to the influence of inadequate pulmonary vascular tone; and (4) resolved when the injured liver is replaced and hepatic function is restored to within normal limits.
Hepatitis B Virus X Protein Blunts Senescence-Like Growth Arrest of Human Hepatocellular Carcinoma by Reducing Notch1 Cleavage
Authors: Jiejie Xu, Xiaojing Yun, Jianhai Jiang, Yuanyan Wei, Yihong Wu, Wei Zhang, Yeheng Liu, Wenzhong Wang, Yumei Wen, Jianxin Gu
Journal: Hepatology (2010)

One of the serious sequelae of chronic hepatitis B virus (HBV) infection is hepatocellular carcinoma (HCC). Among all the proteins encoded by the HBV genome, hepatitis B virus X protein (HBx) is highly associated with the development of HCC. Although Notch1 signaling has been found to exert a tumor-suppressive function during HCC development, the mechanism of interaction between HBx expression and Notch1 signaling needs to be explored. In this study, we report that HBx expression in hepatic and hepatoma cells resulted in decreased endogenous protein levels of Notch1 intracellular domain (ICN1) and messenger RNA levels of its downstream target genes. These effects were due to a reduction of Notch1 cleavage by HBx through the suppression of presenilin1 (Psen1) transcription rather than inhibition of Notch1 transcription or its ligands' expression. Through transient HBx expression, decreased ICN1 resulted in enhanced cell proliferation, induced G1-S cell cycle progression, and blunted cellular senescence in vitro . Furthermore, the effect of blunted senescence-like growth arrest by stable HBx expression through suppression of ICN1 was shown in a nude mouse xenograft transplantation model. The correlation of inhibited Psen1-dependent Notch1 signaling and blunted senescence-like growth arrest was also observed in HBV-associated HCC patient tumor samples. Conclusion: Our results reveal a novel function of HBx in blunting senescence-like growth arrest by decreasing Notch1 signaling, which could be a putative molecular mechanism mediating HBV-associated hepatocarcinogenesis. (Hepatology 2010;)
Increased postabsorptive and exercise-induced whole-body glucose production in patients with chronic obstructive pulmonary disease
Authors: Frits M.E. Franssen, Hans P. Sauerwein, Mariette T. Ackermans, Erica P.A. Rutten, Emiel F.M. Wouters, Annemie M.W.J. Schols
Journal: Metabolism (2010)
Peritoneal Dialysis for Refractory Congestive Heart Failure
Authors: Lionel U. Mailloux
Journal: JAMA (1967)

Peritoneal dialysis with hypertonic dextrose dialyzing solutions was used to dehydrate 15 patients in refractory congestive heart failure. The clinical improvement which was achieved following this procedure could be related largely to the degree of excess fluid removal and visceral decongestion. In these 15 patients there was an average weight loss of 5.2 kg (11.5 lb) and an average excess fluid removal of 7,285 cc. Circulation times and venous pressures fell to 50% of predialysis values, and plasma volumes were reduced in each instance. Of five patients studied, there was only one who showed a substantial increase in cardiac output; the other four patients showed no significant change. Twelve of 15 patients had restored diuretic responsiveness postdialysis. Serum electrolyte values returned toward normal in all patients studied. We have found peritoneal dialysis to be a safe, effective, and valuable ancillary tool in the management of patients with refractory congestive heart failure.
Salivary Inflammatory Mediator Profiling and Correlation to Clinical Disease Markers in Pediatric Atopic Asthma
Authors: F.F. Little, N. Ryzhenko, D.M. Delgado, F.G. Oppenheim, T. Blicharz, D.R. Walt, J. Saams, E.C. Matsui
Journal: Journal of Allergy and Clinical Immunology (2011)
Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human <i>PCSK9</i> Gain-of-Function Mutant
Authors: Rozh H. Al-Mashhadi, Charlotte B. Sørensen, Peter M. Kragh, Christina Christoffersen, Martin B. Mortensen, Lars P. Tolbod, Troels Thim, Yutao Du, Juan Li, Ying Liu, Brian Moldt, Mette Schmidt, Gabor Vajta, Torben Larsen, Stig Purup, Lars Bolund, Lars B. Nielsen, Henrik Callesen, Erling Falk, Jacob Giehm Mikkelsen, Jacob F. Bentzon
Journal: Science Translational Medicine (2013)

A transgenic pig model of familial hypercholesterolemia can be used for translational atherosclerosis research.
Predicting the burden of axillary disease in breast cancer patients with a positive sentinel node.
Authors: B Unal, SA Gur, S Beriwal, R Johnson, G Ahrendt, M Bonaventura, A Soran
Journal: Cancer Research (2009)

Abstract Abstract #1010 Background: Current practice is to perform a completion axillary lymph node dissection (ALND) for breast cancer (BC) patients with tumor-positive sentinel lymph nodes (SLNs). However, not all patients with positive SLNs have further ALND. Katz et al suggested a nomogram for predicting having four or more positive nodes for SLN-positive BC which could change the adjuvant radiation treatment fields. Our goal is to validate the accuracy in predicting &amp;gt; 4 positive axillary lymph nodes in BC patients with a positive SLN in our institution. Methods: Katz nomogram was developed from the multivariate logistic regression model using tumor histology, primary tumor size, lymphovascular space invasion, extranodal extension, the number of involved SLNs, the number of uninvolved SLNs, and the size of the largest SLN metastasis. Area Under (AUC) Receiver Operating Characteristics Curve (ROC) was calculated for the nomogram and a value more than 0.70 was accepted as providing considerable discrimination. Results: We reviewed the records of 319 patients with invasive BC and positive SLNs who underwent completion ALND at MWH of UPMC. None of these patients received neoadjuvant chemotherapy The mean age was 54.2 (30-84) years. Eighty-nine patients (27.8%) had four or more positive nodes. Histology was invasive ductal carcinoma for 86.2 % of patients. The median tumor size was 2.22 (0.5-8.0) cm. Seventy percent of patients had only one involved SLN. The median size of the largest SLN metastasis on H&amp;E staining was 9.7 mm (range, &amp;lt; 0.2 to 35 mm), and 24.4% of the patients had micrometastases (2 mm). Ninety nine patients (31%) had extranodal extension. The mean predicted probability of having ≥ 4 involved axillary LNs was 31.9 % (range, 1 to 99) in patients with ≥ 4 involved axillary LNs while it was it is 9.1% (range, 0.5 to 80) in patients having &amp;lt; 4 axillary LN metastases (P&amp;lt;0.001). The AUC value was 0.809. Conclusions: The Katz nomogram developed to predict having ≥ 4 involved axillary lymph nodes in BC patients with a positive SLNs is validated in our patients. Nomograms developed at other institutions should be used with caution when counseling patients regarding the risk of additional nodal disease. This nomogram will be helpful to clinicians making adjuvant treatment recommendations in practice. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 1010.