Cyclosporine: Renal Effects and Prostacyclin
Authors: RAMON DUARTE
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 March 1985Cyclosporine: Renal Effects and ProstacyclinRAMON DUARTE, M.D.RAMON DUARTE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-3-420_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the excellent review of cyclosporine recently published in this journal (1), the section on nephrotoxic side effects offered no adequate explanation for the frequent reduction in glomerular filtration rate, hypertension, or hyperkalemia that accompany the use of this drug. Of interest in this regard is one study (2) in which patients treated with cyclosporine showed evidence of increased systemic and renal vascular resistance, decreased renal plasma (and blood) flow, and reduced plasma renin activity associated with hypertension, as compared to patients given azathioprine.Could those physiologic (and morphologic) derangements induced by cyclosporine be the result of...References1. COHENLOERTSCHERRUBINTILNEYCARPENTERSTROM DRMNCT. Cyclosporine: a new immunosuppressive agent for organ transplantation. Ann Intern Med. 1984;101:667-82. LinkGoogle Scholar2. MYERSROSSNEWTONLURTSCHERPERCROTH BJLJM. Cyclosporin associated chronic nephropathy. N Engl J M. 1984;311:699-705. CrossrefMedlineGoogle Scholar3. NEILDROCCHIIMBERTI GCL. Effect of cyclosporin on prostacyclin synthesis by vascular tissue in rabbits. Transplant. Proc. 1983;15(4 suppl 1):2398-400. Google Scholar4. GERBEROLSONNIES JRA. Interrelationship between prostaglandins and renin release. Kidney Int. 1981;19:816-21. CrossrefMedlineGoogle Scholar5. SHULMANSTRIKERDERGKENNEDYSTORKTHOMAS HGHMRE. Nephrotoxicity of cyclosporin A after allogeneic marrow transplantation: glomerular thrombosis and tubular injury. N Engl J Med. 1981;305:1392-5. CrossrefMedlineGoogle Scholar1. NIELDROCCHIIMBERTI GGL. Effect of cyclosporine on prostacyclin synthesis by vascular tissue in rabbits. Transplant Proc. 1983;15(4 suppl 1)2398-400. Google Scholar2. NATHBANTLEFERRIS KJT. Effect of cyclosporine A on the renin-angiotensin system and potassium excretion in renal transplant patients [Abstract]. Kidney Int. 1984;25:346. Google Scholar3. ADUMICHAELTURNEYMCMASTER DJJP. Hyperkalaemia in cyclosporin-treated renal allograft recipients. Lancet. 1983;2:370-2. CrossrefMedlineGoogle Scholar4. BAXTERDUGGINWILLISHALLHORVATHTILLER CGNBJD. Cyclosporin A-induced increases in renin storage and release. Res Commun Chem Pathol Pharmacol. 1982;37:305-12. MedlineGoogle Scholar5. SIEGLRYFFELPETRIC HBR. Cyclosporine, the renin-angiotensin-aldosterone system and renal adverse reactions. Transplant Proc. 1983;15:2719-25. Google Scholar6. LINDSEYMORISAKISTITTSZAGERCORNWELL JNJRD. Fatty acid metabolism and cell proliferation: IV. Effect of prostanoid biosynthesis from endogenous fatty acid release with cyclosporin-A. Lipids. 1983;18:566-9. CrossrefMedlineGoogle Scholar7. WHISLERLINDSEYPROCTORMORISAKICORNWELL RJKND. Characteristics of cyclosporine induction of increased prostaglandin levels from human peripheral blood monocytes. Transplantation. 1984;38:377-81. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRenal dysfunction associated with liver transplantation.Prostanoids and cyclosporin-mediated nephrotoxicity in rats: A critical appraisalCyclosporine A nephrotoxicity — the role of thromboxane A2Cytostatics and immunosuppressive drugsCyclosporine and Renal Prostaglandin E2 ProductionROLF A. K. STAHL, M.D., KANZ LOTHAR, M.D., SABINE KUDELKACyclosporine and ProstaglandinsD. ADU, M.D., C. J. LOTE, Ph.D., J. MICHAEL, F.R.C.P., J. H. TURNEY, M.R.C.P., P. MCMASTER, F.R.C.S. 1 March 1985Volume 102, Issue 3Page: 420-420KeywordsAdverse reactionsBlood flowBlood plasmaGlomerular filtration rateHypertensionPlasma renin activityProstacyclinRenal system Issue Published: 1 March 1985 PDF downloadLoading ...