tbuckley/cabot-search huggingface dataset:
Radiation-Induced Esophagitis Masquerading as Disease Progression in Case of Esophageal Carcinoma
Authors: Anirban Mukherjee, Partha Sarathi Chakraborty, Abhishek Behera, Chandrasekhar Bal, Rakesh Kumar
Journal: Clinical Nuclear Medicine (2015)

Radiation esophagitis is one of the commonest complications of the radiotherapy involving esophagus. It is characterized by diffuse radiotracer uptake in the esophagus on ¹⁸F-FDG PET/CT. Thus, it can be often confused with the esophageal malignancy. We present the sequential ¹⁸F-FDG PET/CT images of a 45-year-old woman with locally advanced squamous cell carcinoma of the esophagus who developed radiation esophagitis after chemoradiotherapy. It was confused with the progression of the disease, and the dilemma was resolved by the follow-up PET/CT.
Plasma factor IX levels in patients given hexoestrol or stilboestrol to suppress lactation
Authors: C. A. Hakim, M. G. Elder, D. F. Hawkins
Journal: BMJ (1969)

A single injection of hexoestrol, 45 mg., is effective in suppressing lactation. Given in this way hexoestrol causes a small rise in plasma factor IX levels, of shorter duration than that produced by a customary and equally effective oral course of stilboestrol. With hexoestrol the plasma factor IX levels reverted to normal by the sixth day of the puerperium.
Jaundice During Treatment with an Oral Contraceptive Lyndiol
Authors: G. Cullberg, R. Lundstrom, U. Stenram
Journal: BMJ (1965)

A case history of a woman with icterus suspected to be caused by the oral findings of laboratory data and liver biopsy are given.  A survey of pathological laboratory data of liver functions in various studies of different oral contraceptives is presented in a table.  It is concluded that Lydiol was the probable cause of icterus in this case.
Tamoxifen for Carcinoma of the Male Breast
Authors: Byron L. Coffman
Journal: Annals of Internal Medicine (1993)

Letters1 May 1993Tamoxifen for Carcinoma of the Male BreastByron L. Coffman, MDByron L. Coffman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-9-199305010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As a practicing clinical oncologist, I treat several men with carcinoma of the breast. I certainly agree with Jaiyesimi and colleagues [1] that they need the same degree and type of aggressive treatment given to women with the condition. The Food and Drug Administration (FDA), as well as the manufacturer of Nolvadex, do not appear to concur. I have one patient who is unable to afford the Nolvadex. Nolvadex has a patient assistance program. Despite qualifying on financial grounds, he has been unable to obtain this medication. The company's rationale is that the FDA has not approved ...REFERENCE1. Jaiyesimi IA, Buzdar AU, Sahin AA, Ross MA. Carcinoma of the male breast. Ann Intern Med. 1993; 117:771-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Byron L. Coffman, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1993Volume 118, Issue 9Page: 749KeywordsBreast cancerCancer treatmentDrugsFood and Drug AdministrationSafety ePublished: 15 August 2000 Issue Published: 1 May 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Male Pattern Alopecia Regrowth Following Topical Fluorouracil Therapy
Authors: Robert L. Rietschel
Journal: JAMA (1977)

<h3>To the Editor. —</h3> We wish to report a patient thought to have male pattern baldness for ten years; he began to regrow terminal hair after his scalp was treated with fluorouracil for actinic keratosis. <h3>Report of a Case.—</h3> The patient is a 45-year-old man who had been bald in a frontoparietal distribution for ten years when seen on Sept 27, 1976, at the Dermatology Clinic, Brooke Army Medical Center. He had multiple actinic keratoses of the scalp and was treated with 2% fluorouracil (Efudex) solution followed in ten minutes with 0.5% triamcinolone acetonide cream daily.<sup>1</sup>When seen on Oct 18, 1976, after 21 days of treatment, a confluent, brisk erythema and edema engulfed the scalp, nose, and temples. The fluorouracil therapy was discontinued, and the reaction subsided after three weeks of 0.5% triamcinolone therapy. The patient was not seen again until March 10, 1977, when he returned specifically
Effect of almonds on insulin secretion and insulin resistance in nondiabetic hyperlipidemic subjects: a randomized controlled crossover trial
Authors: David J.A. Jenkins, Cyril W.C. Kendall, Augustine Marchie, Andrea R. Josse, Tri H. Nguyen, Dorothea A. Faulkner, Karen G. Lapsley, William Singer
Journal: Metabolism (2008)
Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC
Authors: Henning Lauterbach, Barbara Bathke, Stefanie Gilles, Claudia Traidl-Hoffmann, Christian A. Luber, György Fejer, Marina A. Freudenberg, Gayle M. Davey, David Vremec, Axel Kallies, Li Wu, Ken Shortman, Paul Chaplin, Mark Suter, Meredith O’Keeffe, Hubertus Hochrein
Journal: The Journal of Experimental Medicine (2010)

Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. IFN-λs (also termed IL-28/29) are potent immunomodulatory and antiviral cytokines. We demonstrate that poly IC injection in vivo induces large amounts of IFN-λ, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes. Upon poly IC injection in vivo, the IFN-λ production by splenocytes segregated with cells phenotypically resembling CD8α+ conventional dendritic cells (DCs [cDCs]). In vitro experiments revealed that CD8α+ cDCs were the major producers of IFN-λ in response to poly IC, whereas both CD8α+ cDCs and plasmacytoid DCs produced large amounts of IFN-λ in response to HSV-1 or parapoxvirus. The nature of the stimulus and the cytokine milieu determined whether CD8α+ cDCs produced IFN-λ or IL-12p70. Human DCs expressing BDCA3 (CD141), which is considered to be the human counterpart of murine CD8α+ DCs, also produced large amounts of IFN-λ upon poly IC stimulation. Thus, IFN-λ production in response to poly IC is a novel function of mouse CD8α+ cDCs and their human equivalents.
Spring Books: Pioneering medicine in South Africa
Authors: A. Paton
Journal: BMJ (1985)

Shakespeare (Taken at the Flood fromJulius Caesar); and from other poets, among whom she seems to have been particularly fond of Lord Tennyson (TheMirror Crack'dfrom Side to Side, from the Lady ofShalou).But above all, she uses nursery rhymes to such an extent that once she lets Hercule Poirot say to himself "I must not always think of nursery rhymes" (Five Little Pigs).And yet that does not ring true.No one arriving late in life from a foreign country could possibly be so familiar with this typically English tradition, which Agatha herself had enjoyed during her happy Torquay childhood.Here, as in some other aspects-the sweet tooth, the frequent use of poisons-it seems likely that Agatha Christie transfers her own feelings and her own knowledge to her imaginative detective.Again, several of the book titles are nursery rhymes, Hickory Dickory Dock, Five Little Pigs, One, Two, Buckle my Shoe, and A
A STUDY OF EPIDERMAL FIBRILS
Authors: R. L. Thompson
Journal: The Journal of Experimental Medicine (1906)

In certain animals, in addition to the protoplasmic fibrils of the stratum filamentosum that are present normally in human epidermis, there are well developed fibrils in the cells of the stratum germinativum. These fibrils are present in the human epidermis only under conditions of increased cell activity. These fibrils, that are prominent in the stratum germinativum of human epidermis under conditions of increased cell activity, seem to increase in direct ratio to rapidity of cell production. The differentiation of these fibrils of the stratum germinativum into the finer fibrils which connect the cells of the stratum filamentosum can be observed under proper conditions of growth and therefore there should be no separation of the fibrils into different groups with various names. This process of fibre production by the cells of the human epidermis is analogous to increased fibre production by various other cells under similar conditions, and may be of importance in identifying or classifying new growths of epithelial origin.
Histopathologic Distinctions in the Relationship of Estrogens and Endometrial Cancer
Authors: Ralph I. Horwitz
Journal: JAMA (1981)

The slides of 233 patients included in a case-control study of estrogens and endometrial cancer were reviewed to determine how often endometrial cancer was misdiagnosed and whether patients with uterine cancer had other coexistent endometrial diseases. Reasonably close agreements were found among the original diagnoses and those of three additional reviewers (the total range of disagreements among all pathologists was from 2% to 16%). Proliferative and hyperplastic endometrium coexisted in many specimens from patients with endometrial cancer, and especially in those who had used estrogen replacement therapy. In contrast, estrogen therapy had seldom been used by patients whose cancers were not accompanied by these proliferative and hyperplastic lesions. In addition, these changes were found significantly more often in women with grade 1 cancers than grade 2 or 3 cancers. We conclude from these data that diagnostic misclassification is uncommon and that coexistent proliferative and hyperplastic lesions occur frequently, especially among women with grade 1 cancers. The data also suggest that the frequent finding of grade 1 cancer in estrogen users is due to bleeding that results from the stimulated coexistent benign proliferating endometrium.
Health Professionals Oppose Rules Mandating Participation in Executions
Authors: Andrew A. Skolnick
Journal: JAMA (1993)

RECENTLY PROPOSED regulations that would mandate physician participation in federal executions is meeting strong opposition from many physicians and other health professionals. The American Medical Association (AMA), American College of Physicians, American Public Health Association, American Nurses Association, and other health professionals were taken by surprise when outgoing US Attorney General William P. Barr announced—in the November 30,1992,<i>Federal Register</i>— proposed procedures for carrying out federal death sentences. The proposed regulations would establish lethal injections as the means of death in federal executions and would require the presence of at least one physician. They would also require a "physician or other qualified person" to declare death. The US Department of Justice allowed only a 30-day period for comments, which ended December 30. Final regulations are expected soon. Response from the medical community to the attorney general's announcement was loud and clear. To publicize their opposition to the proposed regulations,
Prevalence of polycythemia vera and essential thrombocythemia
Authors: Xiaomei Ma, Gary Vanasse, Brenda Cartmel, Yun Wang, H. Andrew Selinger
Journal: American Journal of Hematology (2008)

Abstract Polycythemia vera (PV) and essential thrombocythemia (ET) are common types of myeloproliferative disorders (MPD), the prevalence of which has not been well documented in the United States. Recent breakthroughs in the molecular etiology of these disorders and the accelerated development of targeted pharmacotherapeutics to treat them underscore the need to define the affected population. In this study, we obtained health claims data from major commercial insurance payers in Connecticut and the Center for Medicare and Medicaid Services to estimate the prevalence of PV and ET. Specifically, logistic regression was utilized to develop algorithms to predict the probability that an individual with claims suggestive of MPD truly has PV or ET, and the algorithms were then applied to health claims to estimate the number of PV and ET patients in Connecticut. As of 2003, the age‐standardized prevalence was 22 per 100,000 and 24 per 100,000 for PV and ET, respectively, in Connecticut. Applying the age‐specific prevalence of PV and ET to the entire US population resulted in an estimated total of 65,243 patients with PV and 71,078 patients with ET in the United States in 2003. This study is the first to assess the prevalence of PV and ET in a large US population. Given the large number of individuals afflicted with these diseases and the fact that demographic changes alone will further increase the burden of these diseases in the foreseeable future, it is imperative to conduct more systematic research into the etiology and treatment of PV and ET. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
EXPERIMENTAL NEPHRITIS IN THE FROG
Authors: Jean Oliver, Pearl Smith
Journal: The Journal of Experimental Medicine (1930)

1. The damage produced by corrosive sublimate, potassium bichromate and uranium nitrate in the frog's kidney is described. 2. The morphological lesions consist of evidences of tubular damage, such as regressive changes in the epithelium, and of damage to the glomeruli ranging from increase in their permeability to gross damage of and hemorrhage from the tuft. 3. The point is emphasized that these lesions differ in their degree rather than in their nature from those found in the mammalian kidney after the administration of the same poisons. 4. The frog's kidney is exceptionally well suited therefore for the study of lesions which though present are masked in the complexities of structure and function of the mammalian kidney.
Chemotherapy of Tropical Diseases
Authors: Harold Brown
Journal: JAMA (1962)

This 164-page book gives a most useful and up-to-date summary of the chemotherapy of tropical diseases. The following chapter headings indicate the scope of this work: (1) Protozoal Diseases, (2) Spirochaetal Diseases, (3) Rickettsial Diseases, (4) Bacterial Diseases, (5) Fungal Infections, (6) Nutritional Diseases, (7) Climatic Diseases, (8) Metazoal Diseases, and (9) Venereal Diseases. There is a useful summary list of drugs employed in the treatment of tropical diseases. It is most convenient to have all of this material gathered together in one volume, for it saves searching through many books. For a number of diseases, several chemotherapeutic agents are mentioned, usually in historical order which means that the older discarded drugs come first. It is unfortunate that the author does not indicate the current drug of choice. This is not important to experts in the field, but for the internists or general practitioners it would be most valuable. One
Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease
Authors: Eun Young Choi, Gregory J. Christianson, Yoshitaka Yoshimura, Nadja Jung, Thomas J. Sproule, Subramaniam Malarkannan, Sebastian Joyce, Derry C. Roopenian
Journal: Blood (2002)
Abstract 2247: Histone H3 cleavage via Cathepsin L drives a cellular senescence program
Authors: Luis F. Duarte, Andrew R. Young, Hsan-Au Wu, Taniya Panda, Zichen Wang, Alexandre G. Maia, Dan Hasson, Avnish Kapoor, Masashi Narita, Emily Bernstein
Journal: Cancer Research (2014)

Abstract Oncogene-induced senescence (OIS) is characterized by irreversible loss of proliferative capacity. It has been proposed that OIS functions as a tumor suppressor mechanism, and several studies have demonstrated induction of senescence markers in pre-malignant lesions. In addition to profound morphological changes, significant alterations in chromatin structure occur during senescence including formation of senescence-associated heterochromatin foci (SAHF). We have used well-characterized senescence models in human primary lung fibroblasts and melanocytes to study how chromatin alterations contribute to the senescence phenotype. We discovered that the N'-terminal tail of histone H3 is proteolytically cleaved by the lysosomal protease Cathepsin L1 (CTSL1). We show that CTSL1 is induced during senescence both at the mRNA and protein levels, and that it is present in the chromatin fraction of senescent cells. Chemical and shRNA-mediated inhibition of CTSL1 activity effectively block H3 tail cleavage and leads to a SAHF formation defect. We identified two distinct cleaved forms of H3 in senescent cells, which are associated with chromatin and incorporated into nucleosomes. Using antibodies directed against specific post-translational modifications (PTMs) of the histone H3 tail, we have mapped the approximate locations of the cleavage sites. Furthermore, overexpression of flag-tagged cleaved versions of H3, but not the full-length histone, trigger robust senescence in IMR90 cells accompanied by a modest induction of SAHFs. Interestingly, we also detect cleaved H3 in chromatin extracted from benign nevi tissue samples, providing evidence of H3 tail cleavage in senescence models in vivo. Collectively, our results suggest that H3 tail cleavage may contribute significantly to the senescence phenotype, potentially through transcriptional regulation of key senescence target genes. This area of investigation is currently ongoing. Citation Format: Luis F. Duarte, Andrew R. Young, Hsan-Au Wu, Taniya Panda, Zichen Wang, Alexandre G. Maia, Dan Hasson, Avnish Kapoor, Masashi Narita, Emily Bernstein. Histone H3 cleavage via Cathepsin L drives a cellular senescence program. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2247. doi:10.1158/1538-7445.AM2014-2247
Key questions concerning paracetamol and NSAIDs for OA
Authors: K D Brandt
Journal: Annals of the Rheumatic Diseases (2003)

If you have a burning desire to respond to a paper published in the <i>Annals of the Rheumatic Diseases</i>, why not make use of our "rapid response" option? Log on to our website (www.annrheumdis.com), find the paper that interests you, and send your response via email by clicking on the "eLetters" option in the box at the top right hand corner. Providing it isn't libellous or obscene, it will be posted within seven days. You can retrieve it by clicking on "read eLetters" on our homepage. The editors will decide as before whether also to publish it in a future paper issue.
Single-Unit Blood Transfusion: Doubtful Dogma Defeated
Authors: Roger M. Cass
Journal: JAMA (1987)

<h3>To the Editor.—</h3> It has been said that the single-unit blood transfusion is "acknowledged to be unnecessary,"<sup>1</sup>and for many years the Joint Commission on Accreditation of Hospitals required hospital transfusion committees to review all single-unit transfusions. We report the case of a small elderly woman whose hematocrit rose from 28% (0.28) to 41% (0.41) with transfusion of a single unit of packed red blood cells and review the experience with single-unit transfusions at our hospital. <h3>Report of a Case.—</h3> An 80-year-old woman was admitted to the hospital's long-term care unit for rehabilitation following hip and wrist fractures; she had a long history of deafness and chronic bronchitis but was otherwise healthy. The patient was small (height, 142 cm; weight, 35.9 kg), with bilateral rhonchi in both lung fields. The results of the physical examination were within normal limits. While she was hospitalized, it was noted that her hematocrit
The Diagnostic Performance of Computer Programs for the Interpretation of Electrocardiograms
Authors: Jos L. Willems, Cassiano Abreu-Lima, Pierre Arnaud, Jan H. van Bemmel, Christian Brohet, Rosanna Degani, Bernard Denis, Jürgen Gehring, Ian Graham, Gerard van Herpen, Hilario Machado, Peter W. Macfarlane, Jörg Michaelis, Spyridon D. Moulopoulos, Paul Rubel, Christoph Zywietz
Journal: New England Journal of Medicine (1991)

Computer programs for the interpretation of electrocardiograms (ECGs) are now widely used. However, a systematic assessment of various computer programs for the interpretation of ECGs has not been performed.
The Sorcerer's Apprentice: How Medical Imaging Is Changing Health Care
Authors: Sarah D. Bixby
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Focal and Diffuse FDG Uptake Patterns of Endotracheal Lymphoma
Authors: Aisheng Dong, Tiejun Zhao, Yang Wang, Changjing Zuo
Journal: Clinical Nuclear Medicine (2013)

Endotracheal infiltration by lymphoma is uncommon. We present 2 cases of endotracheal infiltration by non-Hodgkin lymphoma. One case had a solitary lesion in the middle trachea. Bronchoscopic biopsy of the lesion revealed diffuse large B-cell lymphoma. The tumor showed focal FDG uptake with SUVmax of 15. The other case had diffuse endotracheal lesions. Bronchoscopic biopsy revealed diffuse submucosal infiltration by natural killer/T-cell lymphoma. The thickened trachea showed diffuse FDG uptake with SUVmax of 8.4. These 2 cases indicate lymphoma should be included in the differential diagnosis of focal or diffuse endotracheal FDG accumulation.
Points from Letters: Puffs per Aerosol
Authors: C. Boroda, R. B. Miller
Journal: BMJ (1972)

<h3>Abstract</h3> Long intergenic non-coding RNAs (lincRNAs) have been implicated in aspects of gene regulation, but their requirement for development needs empirical interrogation. To begin to understand the roles lincRNAs might play in heart development, we computationally identified nine murine lincRNAs that have developmentally regulated transcriptional and epigenomic profiles specific to early heart differentiation. Six of the nine lincRNAs had in vivo expression patterns supporting a potential function in heart development, including a transcript downstream of the cardiac transcription factor <i>Hand2</i> that we named <i>Handlr (Hand2</i>-associated lincRNA), <i>Rubie,</i> and <i>Atcayos</i>. We genetically ablated these six lincRNAs in mouse, which implicated genomic regulatory roles to four of the cohort, However, none of the lincRNA deletions led to severe cardiac phenotypes. Thus, we stressed the hearts of adult <i>Handlr</i> and <i>Atcayos</i> mutant mice by transverse aortic banding and found that absence of these lincRNAs did not affect cardiac hypertrophy or left ventricular function post-stress. Our results support roles for lincRNA transcripts and/or transcription to regulation of topologically associated genes. However, the individual importance of developmentally-specific lincRNAs is yet to be established. Their status as either gene-like entities or epigenetic components of the nucleus should be further considered.