tbuckley/cabot-search huggingface dataset:
Article was a gift to minister of health just before general election
Authors: C. Terzi
Journal: BMJ (2011)

There will be a general election in June 2011 in Turkey, and the government’s Health Transformation Programme (HTP) is one of the main topics of political debate. I was therefore disturbed by the timing of your article about healthcare in Turkey,1 which flattered the government. Two of its authors work in the health ministry as high level bureaucrats.

Most Turkish doctors, however, think that …
Mortality and Morbidity in Surgical Patients With Coronary Artery Disease
Authors: Robert Arkins, Andre A. Smessaert, Robert G. Hicks
Journal: JAMA (1964)

A two-month postoperative follow-up of 1,005 patients with coronary artery disease demonstrated that 225 patients, or 22.3%, died. This mortality was twice that of surgical patients in similar circumstances but without specific diagnosis of coronary artery disease. Among 27 patients who had suffered a preoperative myocardial infarction, less than three months before surgery, 11 died; this mortality of 40% was higher than the overall rate. The type of infarction was found to be significant, with a much lower mortality following subendocardial lesions as compared to transmural infarctions. Postoperative myocardial infarction was observed in 55 cases and resulted in 38 deaths, a mortality of 69%. Comparison of the various agents and methods used for anesthesia failed to show a significant difference.
THE VALUE OF HYDROGEN PEROXID IN THE MICROCHEMICAL DETERMINATION OF IRON
Authors: W. H. Brown
Journal: The Journal of Experimental Medicine (1911)

1. It has been shown that hemoglobin in solution or within the red blood corpuscles can be oxidized by hydrogen peroxid to form a colorless substance capable of manifesting a microchemical reaction for iron, the type of the reaction depending upon the degree of oxidation. 2. It has been further shown that hematin and hemin, when treated with hydrogen peroxid, are decolorized. The colorless or nearly colorless body, preserving the form of the original body and being an intermediate product of its oxidation, will also exhibit a typical reaction for iron. 3. A method has been described for obtaining microchemical reaction for iron from hemoglobin and its various modifications and iron-containing derivatives, from tissue cells, from cell nuclei, and from eosinophil granules, by an appropriate degree of oxidation with hydrogen peroxid.
AN EXAMINATION OF VON GRAEFE'S DOCTRINE OF "ANTIPATHY TO SINGLE VISION."
Authors: GEORGE T. STEVENS
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Natural Lymphocyte Effector Cells: Definition, Analysis of Activity, and Clinical Effectiveness
Authors: J. R. Ortaldo, D. L. Longo
Journal: JNCI Journal of the National Cancer Institute (1988)

Lymphokine-activated killing has enormous potential in the treatment of cancer. Lymphoid effectors have the potential to recognize and lyse a wide array of tumor cells, a phenomenon which has been seen in vitro and to some extent in vivo. However, studies have indicated that complexity exists not only in the nature of the lymphocyte that can be activated ex vivo for therapeutic use, but also in the delivery of such therapy in a clinical setting. This review attempts to deal with both issues. The nature of the cells mediating lymphokine-activated killer activity, their heterogeneous phenotype, their activation requirements, and a hypothetical mechanism of action are discussed. In addition, previous clinical studies are reviewed and key issues are raised that need to be addressed in upcoming clinical trials.
The effect of helper virus on Abelson virus-induced transformation of lymphoid cells.
Authors: N Rosenberg, D Baltimore
Journal: The Journal of Experimental Medicine (1978)

Abelson murine leukemia virus (A-MuLV)-transformed fibroblast nonproducer cells were used to prepare A-MuLV stocks containing a number of different helper viruses. The oncogenicity of the A-MuLV stocks was tested by animal inoculation and their ability to transform normal mouse bone marrow cells was measured in vitro. All of the A-MuLV stocks transformed fibroblast cells efficiently. However, only A-MuLV stocks prepared with helper viruses that are highly oncogenic were efficient in vivo and in vitro in hematopoietic cell transformation. In addition, inefficient helpers did not establish a stable infection in lymphoid nonproducer cells. Thus, helper virus has a more central role in lymphoid cell transformation than in fibroblast cell transformation.
Hypotension and Oliguria in Staphylococcal Pneumonia
Authors: G. Kellaway, H. Le Grice
Journal: BMJ (1962)

Since the introduction of antibiotic therapy over eighteen years ago the Staphylococcus aureus has gradually acquired considerable notoriety, not only for an ability to develop resistance to each new antibiotic discovered but also for a tendency to produce severe toxicity where there is systemic involvement. Recent intensive studies of staphylococcal infections provide much information concerning epidemiology (Williams et al., 1959; Bernsten and McDermott, 1960), drug-resistant strains (Barber et al., 1958 ; Waisbren and Strelitzer, 1959; Lowbury, 1960), efficacy of treatment with various antibiotics (Walker et al., 1958; Lancet, 1960; Kirby et al., 1960; Douthwaite and Trafford, 1960), and radiological features (Gibson and Belcher, 1951; Oswald et al., 1958; Meyers and Jacobson, 1959) where there is lung involvement. Detailed evaluation of the course of treated staphylococcal pneumonia and of the complications encountered has received less generous attention.
c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells
Authors: Chun Chou, Amelia K Pinto, Jonathan D Curtis, Stephen P Persaud, Marina Cella, Chih-Chung Lin, Brian T Edelson, Paul M Allen, Marco Colonna, Erika L Pearce, Michael S Diamond, Takeshi Egawa
Journal: Nature Immunology (2014)
“Dewlap”
Authors: Guillermo E. Lucena, William M. Bennett, Robert V. Pierre
Journal: New England Journal of Medicine (1966)

A CHARACTERISTIC pattern of obesity confined to the face, posterior cervical and supraclavicular areas and trunk is seen in Cushing's disease and Cushing syndrome and after corticosteroid therapy. We recently observed 3 patients with localized, fatty tumors in the episternal area while being treated with adrenocortical steroids. These tumors are of interest since they have not been specifically emphasized as part of the obesity pattern of corticosteroid excess. They are reversible; they may be unnecessarily excised.Case ReportsCase 1. E.H., a 51-year-old man, entered the Veterans Administration Research Hospital on February 19, 1965, with superficial thrombophlebitis of the right . . .
True and False Experts: A Second Look
Authors: DAVID S. WERMAN
Journal: American Journal of Psychiatry (1973)

In 1878 Dr. Eugene Grissom examined a number of forensic and reform issues concerning psychiatry and attacked a colleague who had been critical of the profession. The ensuing confrontation between the two seems particularly significant today. Both from within and without, psychiatry is being criticized for its exclusiveness, élitism, and traditionalism. As was the case almost 100 years ago, the issue often seems to be less a matter of the substantive nature of the criticism and rebuttals than one of hostility toward psychiatry itself.
Abstract 2115: Increased sensitivity of <i>KRAS</i> mutation detection by High-Resolution Melting analysis of COLD-PCR products
Authors: Iben L. Daugaard, Lasse S. Kristensen, Tina Kjeldsen, Stephen Hamilton Dutoit, Henrik Hager, Lise Lotte Hansen
Journal: Cancer Research (2010)

Abstract Much effort has been put into the development of sophisticated technologies enabling the detection of clinically significant low-level tumor specific KRAS mutations. The constitutively active KRAS oncogene harbors a mutation hotspot in codon 12 and 13 of exon 2. These mutations are predictors of response to treatment with the monoclonal antibodies panitumumab and cetuximab targeting the epidermal growth factor receptor (EGFR). Therefore, it is crucial to develop robust and sensitive assays targeting these mutations. Coamplification at lower denaturation temperature-PCR (COLD-PCR) is a new form of PCR that selectively amplifies mutation containing amplicons based on the lower melting temperature of heteroduplexes versus homoduplexes. We have developed an assay based on real-time COLD-PCR and high-resolution melting (HRM) targeting codon 12 and 13 for simultaneous detection of the various mutations found in this mutation hotspot. By using mutation containing cell-lines serially diluted into wild-type DNA we have compared the sensitivity of HRM after standard PCR with the sensitivity of HRM after COLD-PCR. We have also analyzed 60 colorectal cancer samples for which KRAS mutation status previously has been evaluated by the DxS kit which is approved by the U.S. Food and Drug Administration. Replacing standard PCR by COLD-PCR increased the sensitivity of the assay by up to 50 fold depending on the specific mutation. Furthermore, we have obtained very similar results when using our COLD-PCR assay as we obtained when using the DxS kit and confirmed the HRM results with Sanger sequencing. In conclusion, applying COLD-PCR to HRM analysis is a simple way of increasing the sensitivity of KRAS mutation detection without adding to the complexity and cost of the experiments. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2115.
Many cytokines are very useful therapeutic targets in disease
Authors: Marc Feldmann
Journal: Journal of Clinical Investigation (2008)

Cytokines are a large family of more than 100 small proteins that function as short-range mediators involved in essentially all biological processes. They have been found to be important rate-limiting signals, and it is now known that blocking some cytokines, e.g., TNF-alpha, and cytokine receptors, such as human EGFR 1 (HER1) or HER2, yields effective therapeutics that address unmet needs. This Review Series surveys three chronic inflammatory disease areas and two forms of cancer and discusses the important role of cytokines and their receptors in these disease processes. Their role as potential therapeutic targets is also highlighted.
1082-177 Impact of NAD(P)H oxidase-derived reactive oxygen species on plaque formation and vascular remodelling: Comparison of histochemical characteristics and intravascular ultrasound finding of atherosclerotic lesions
Authors: Mitsuyasu Terashima, Yoshitaka Ohashi, Nobutaka Inoue, Kojiro Awano, Seiichi Kobayashi, Hiroshi Azumi, Takao Mori, Shinobu Ichikawa, Tomoyuki Honjo, Katsuya Kobayashi, Mitsuhiro Yokoyama
Journal: Journal of the American College of Cardiology (2004)
Blakemore asks for the MRC budget to be doubled
Authors: G. Watts
Journal: BMJ (2003)

Twenty years of relative neglect of the university sector has lead to a degradation of its infrastructure, Professor Colin Blakemore, chief executive of the Medical Research Council (MRC), told the House of Commons Science and Technology Committee this week.

Questioned about the state of research in Britain today, Professor Blakemore said: “The strength of British biomedical research is that we live in a culture that places a value on scholarship and individual effort.” “Unfortunately,” he …
National Study of Physician Awareness and Adherence to Cardiovascular Disease Prevention Guidelines
Authors: Lori Mosca, Allison H. Linfante, Emelia J. Benjamin, Kathy Berra, Sharonne N. Hayes, Brian W. Walsh, Rosalind P. Fabunmi, Johnny Kwan, Thomas Mills, Susan Lee Simpson
Journal: Circulation (2005)

Few data have evaluated physician adherence to cardiovascular disease (CVD) prevention guidelines according to physician specialty or patient characteristics, particularly gender.An online study of 500 randomly selected physicians (300 primary care physicians, 100 obstetricians/gynecologists, and 100 cardiologists) used a standardized questionnaire to assess awareness of, adoption of, and barriers to national CVD prevention guidelines by specialty. An experimental case study design tested physician accuracy and determinants of CVD risk level assignment and application of guidelines among high-, intermediate-, or low-risk patients. Intermediate-risk women, as assessed by the Framingham risk score, were significantly more likely to be assigned to a lower-risk category by primary care physicians than men with identical risk profiles (P<0.0001), and trends were similar for obstetricians/gynecologists and cardiologists. Assignment of risk level significantly predicted recommendations for lifestyle and preventive pharmacotherapy. After adjustment for risk assignment, the impact of patient gender on preventive care was not significant except for less aspirin (P<0.01) and more weight management recommended (P<0.04) for intermediate-risk women. Physicians did not rate themselves as very effective in their ability to help patients prevent CVD. Fewer than 1 in 5 physicians knew that more women than men die each year from CVD.Perception of risk was the primary factor associated with CVD preventive recommendations. Gender disparities in recommendations for preventive therapy were explained largely by the lower perceived risk despite similar calculated risk for women versus men. Educational interventions for physicians are needed to improve the quality of CVD preventive care and lower morbidity and mortality from CVD for men and women.
Subclinical cardiovascular disease is associated with a high glomerular filtration rate in the nondiabetic general population
Authors: Bjørn O. Eriksen, Maja-Lisa Løchen, Kjell A. Arntzen, Geir Bertelsen, Britt-Ann W. Eilertsen, Therese von Hanno, Marit Herder, Trond G. Jenssen, Ulla D. Mathisen, Toralf Melsom, Inger Njølstad, Marit D. Solbu, Ingrid Toft, Ellisiv B. Mathiesen
Journal: Kidney International (2013)
Antibody derivatization and conjugation strategies: Application in preparation of stealth immunoliposome to target chemotherapeutics to tumor
Authors: Arehalli S. Manjappa, Kiran R. Chaudhari, Makam P. Venkataraju, Prudhviraju Dantuluri, Biswarup Nanda, Chennakesavulu Sidda, Krutika K. Sawant, Rayasa S. Ramachandra Murthy
Journal: Journal of Controlled Release (2010)
Ovulation and Increased FDG Uptake on PET: Potential for a False-Positive Result
Authors: S Short, P Hoskin, W Wong
Journal: Clinical Nuclear Medicine (2005)

F-18 FDG PET is increasingly used in the assessment of malignant disease. Normal physiologic activity of FDG can lead to false-positive results. The case of a patient with prior squamous cell carcinoma of the urethra and FDG uptake in the right ovary related to physiological activity during ovulation is presented. Suspicion for physiological ovarian uptake is necessary when assessing PET imaging of females of reproductive age when there is uptake of FDG in the ovarian region. It is therefore important to take a menstrual history and compare PET with cross-sectional imaging in an attempt to exclude physiological causes.
Ultraviolet-irradiated monocytes efficiently inhibit the intracellular replication of Mycobacterium avium intracellulare.
Authors: W S Mirando, H Shiratsuchi, K Tubesing, H Toba, J J Ellner, C A Elmets
Journal: Journal of Clinical Investigation (1992)

The purpose of this study was to evaluate the effect of ultraviolet (UV) radiation on the antimicrobial activities of monocytes for the intracellular pathogen Mycobacterium avium intracellulare (MAI). UV radiation augmented monocyte antimicrobial activity for MAI in a dose-dependent fashion. UVB doses of greater than or equal to 25 J/m2 resulted in a 50-100-fold reduction in MAI growth 7 d after initiation of culture. The increased monocyte antibacterial effect could be blocked by a plate glass filter, indicating that wavelengths within the UVB were responsible for the effect. UV radiation did not stimulate monocyte phagocytosis, and enhanced inhibition of MAI growth was observed in populations of adherent mononuclear cells that were devoid of T cells. This suggested that UV radiation acted directly to augment intrinsic monocyte antimicrobial activities. The administration of 8-methoxypsoralen plus UVA radiation to monocytes also augmented their antimicrobial activities against MAI. UV radiation thus may serve as a unique agent by which to evaluate the mechanisms by which mononuclear phagocytes control the growth of MAI.
Hepatitis B in a Prenatal Population
Authors: Wayne M. Dankner
Journal: JAMA (1993)

<h3>To the Editor.</h3> —We read with interest the article by Silverman et al<sup>1</sup>in the November 27, 1991, issue of<i>JAMA</i>. The authors found a high rate of hepatitis B surface antigen (HBsAg) positivity (6.7%) among their unregistered prenatal population. Positivity was highly correlated with positive urine drug test results. They recommended initiating hepatitis B virus (HBV) prophylaxis to neonates born of unregistered mothers, especially those with positive drug-test results. At the University of California San Diego Medical Center, with an average of about of 4000 deliveries per year, 25% to 30% of women present with no prenatal care. Included in the battery of tests for these women are HBsAg and urine drug screening. In order to compare our population with that of Silverman et al, we reviewed similar demographic, laboratory, and clinical data from our unregistered patients for one calendar year. In 1990 there were 3981 deliveries of
Early Detection of Lung Cancer Using Serum RNA or DNA Markers: Ready for “Prime Time” or for Validation?
Authors: Paul A. Bunn
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.07.976 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 14507944 Early Detection of Lung Cancer Using Serum RNA or DNA Markers: Ready for “Prime Time” or for Validation? Paul A. Bunn JrxPaul A. Bunn JrSearch for articles by this author Show More University of Colorado Cancer Center, Denver, CO https://doi.org/10.1200/JCO.2003.07.976 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Recent advances in tropical medicine
Authors: D N J Lockwood, G Pasvol
Journal: BMJ (1994)

Preventing overuse injury in children * Careful supervision by coaches and parents * Equipment checked regularly for fit and wear * Practice intensity and duration increased only gradually * Poor technique or posture recognised and corrected * Warm up and stretch exercises before and after sportChildren who actively participate in sport should not be treated as miniature adults: they need careful assessment in relation to the common problems that affect a growing skeleton.Overuse syndromes can be avoided by careful supervision from coaches and sensible parents.General practitioners should refer children who are keen athletes to orthopaedic surgeons as soon as possible to allow early treatment and to avoid a long interruption of sporting activities.
Surgical Delivery in Under-resourced Settings
Authors: Meera Kotagal, Karen Horvath
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Corticosteroid treatment in sarcoidosis
Authors: J. C. Grutters, J. M. M. van den Bosch
Journal: European Respiratory Journal (2006)

At present there is no curative treatment for sarcoidosis. Immunosuppressive and/or immunomodulatory drugs can, however, be used for controlling the disease. Corticosteroids remain the mainstay of therapy. They function by suppressing the pro-inflammatory cytokines and chemokines that are involved in cell-mediated immune responses and granuloma formation. Only in a select group of patients is it justifiable to use these drugs, after careful evaluation of the pros and cons. Importantly, disease severity, e.g. threatened organ functions, and not disease activity itself should be the deciding factor in this process. In the case of parenchymal involvement, there is substantial evidence that corticosteroids can improve respiratory symptoms and chest radiography and lung function parameters over 6-24 months. Other generally acknowledged (empirical) criteria for systemic treatment include neurological, cardiac and sight-threatening ocular involvement and hypercalcaemia. Remarkably, despite >50 yrs of use, there is no proof of long-term (survival) benefit from corticosteroid treatment. In addition, there are still no data regarding the optimal dose and duration of corticosteroid or other immunosuppressive therapy. One of the weightiest questions remaining is whether or not these drugs can prevent scarring in patients with a fibrogenic phenotype. As new agents, including infliximab and thalidomide, enter the stage and new diagnostic tools are now available, there is clearly a momentum to design multicentric randomised controlled trials with long enough follow-up (>5 yrs) to answer this pivotal question.
MRC is failing to turn basic research into commercial success, report says
Authors: Michael Day
Journal: BMJ (2006)

The performance of the Medical Research Council (MRC) has been transformed in the past few years, but serious failings remain, a parliamentary investigation into the United Kingdom's research councils has found.

Mounting concern over the management of the council culminated in a scathing attack on its finances and strategic planning by the House of Commons Science and Technology Committee in March 2003 ( BMJ 2003;326:732).

Phil Willis, the committee's current chairman, said much progress had since been made. “It now has a clarity of vision and focus. That wasn't the case three or …