tbuckley/cabot-search huggingface dataset:
Allium vegetables and organosulfur compounds: do they help prevent cancer?
Authors: F Bianchini, H Vainio
Journal: Environmental Health Perspectives (2001)

Allium vegetables have been shown to have beneficial effects against several diseases, including cancer. Garlic, onions, leeks, and chives have been reported to protect against stomach and colorectal cancers, although evidence for a protective effect against cancer at other sites, including the breast, is still insufficient. The protective effect appears to be related to the presence of organosulfur compounds and mainly allyl derivatives, which inhibit carcinogenesis in the forestomach, esophagus, colon, mammary gland, and lung of experimental animals. The exact mechanisms of the cancer-preventive effects are not clear, although several hypotheses have been proposed. Organosulfur compounds modulate the activity of several metabolizing enzymes that activate (cytochrome P450s) or detoxify (glutathione S-transferases) carcinogens and inhibit the formation of DNA adducts in several target tissues. Antiproliferative activity has been described in several tumor cell lines, which is possibly mediated by induction of apoptosis and alterations of the cell cycle. Allium vegetables and organosulfur compounds are thus possible cancer-preventive agents. Clinical trials will be required to define the effective dose that has no toxicity in humans.
How will changes in physician payment by Medicare influence laboratory testing?
Authors: J. M. Eisenburg
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Speed: The Challenge to Medicine in the New Era
Authors: Richard V. Lee
Journal: Annals of Internal Medicine (2000)

Editorials4 January 2000Speed: The Challenge to Medicine in the New EraRichard V. Lee, MD and Frank Davidoff, MDRichard V. Lee, MDMillennium Issue Editor (Lee)Editor (Davidoff)Search for more papers by this author and Frank Davidoff, MDMillennium Issue Editor (Lee)Editor (Davidoff)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-1-200001040-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this world there are two times. There is mechanical time and there is body time … . The first is unyielding, predetermined. The second makes up its mind as it goes along … . Each time is true, but the truths are not the same (1).At its most basic level, the coming of a millennium has strictly to do with calendars. As such, it is an arbitrary, culture-bound event, a point underscored by the realization that even the nominal starting date for the new era, 1 January 2000, is wrong. It is a year early, because Dionysius Exiguus, ...References1. Lightman A. Einstein's Dreams. New York: Warner Books; 1993:23-7. Google Scholar2. Stoiber J. When does the new millennium start? Philadelphia Inquirer. 22 January 1999:A15. Google Scholar3. Anderson J. What the millennium bug tells us about ourselves. BMJ. 1999;319:464-5. CrossrefMedlineGoogle Scholar4. Gleick J. Faster. The Acceleration of Just about Everything. New York: Pantheon Books; 1999. Google Scholar5. Brand S. The Clock of the Long Now. Time and Responsibility: The Ideas Behind the World's Slowest Computer. New York: Basic Books; 1999:34-9. Google Scholar6. Gleick J. Faster. The Acceleration of Just About Everything. New York: Pantheon Books, 1999:101. Google Scholar7. Brand S. The Clock of the Long Now. Time and Responsibility: The Ideas Behind the World's Slowest Computer. New York: Basic Books; 1999. Google Scholar8. Davidoff F. Time [Editorial]. Ann Intern Med. 1997;127:483-5. LinkGoogle Scholar9. Brand S. The Clock of the Long Now. Time and Responsibility: The Ideas Behind the World's Slowest Computer. New York: Basic Books; 1999:82-92. Google Scholar Author, Article, and Disclosure InformationAuthors: Richard V. Lee, MD; Frank Davidoff, MDAffiliations: Millennium Issue Editor (Lee)Editor (Davidoff) Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 January 2000Volume 132, Issue 1Page: 90-91KeywordsCaregiversForecastingHealth careHistory of medicineMedical educationRunningSimulation and modelingStatistical modelsTelemedicineVision ePublished: 15 August 2000 Issue Published: 4 January 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Wringing motion of normal left ventricle quantified with tissue doppler echocardiography
Authors: Yuichi Notomi, Hirotsugu Yamada, Zoran B. Popovic, Jianxin Qin, Neil L. Greenberg, Yasuhiko Abe, Ryoichi Kanda, James D. Thomas, Takahiro Shiota
Journal: Journal of the American College of Cardiology (2003)
Mutations in the human retinal degeneration slow (RDS) gene can cause either retinitis pigmentosa or macular dystrophy
Authors: John Wells, John Wroblewski, Jeffrey Keen, Christopher Inglehearn, Christopher Jubb, Anja Eckstein, Marcelle Jay, Geoffrey Arden, Shomi Bhattacharya, Fred Fitzke, Alan Bird
Journal: Nature Genetics (1993)
Tom Cruise is dangerous and irresponsible
Authors: U. S. Neill
Journal: Journal of Clinical Investigation (2005)

Yes, even the JCI can weigh in on celebrity gossip, but hopefully without becoming a tabloid. Rather, we want to shine a light on the reckless comments actor Tom Cruise has recently made that psychiatry is a "quack" field and his belief that postpartum depression cannot be treated pharmacologically. We can only hope that his influence as a celebrity does not hold back those in need of psychiatric treatment.
Gene expression and gene structure: an interview with Bert W. O'Malley
Authors: B. W. O'Malley
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Diagnostic Laboratory Tests for Histoplasmosis
Authors: JOSEPH WHEAT
Journal: Annals of Internal Medicine (1982)

Of 495 patients reported in a large urban histoplasmosis outbreak, we studied 276 whose serologic tests were done in a single laboratory. Serologic test results were positive in 96% of these patients (compared with less than 5% of controls from an endemic area), cultures were positive in 22%, and special stains in 19%. The immunodiffusion test results were negative in 13% of patients who had positive findings by complement fixation, and 1% had positive results only by immunodiffusion. The complement fixation test was almost twice as sensitive as the immunodiffusion test in patients with subclinical infection. The serologic response differed significantly among the clinical syndromes with higher titers in cavitary and lower titers in disseminated disease. Factors associated with titers of 1:64 or greater to both antigens were black race and immunocompetence. High mycelial titers were also associated with more intense exposure, and high yeast titers were associated with age less than 36 years. No prognostic significance could be proved for fourfold titer rises or falls or persistence of precipitins.
592 A multicentric, randomized, controlled, double-blind study (TRIPEG): PEGINF α-2b, ribavirin and amantadine or PEGINF α-2b, placebo, in 269 naive patients with chronic hepatitis C
Authors: V. Calay, S. Hachemane, G.P. Pageaux, M. Canva, M. Bourlière, I. Portals, R. Goria, A. Tran, J.P. Arpurt, M.C. Bozonat, J.P. Daurès, D. Larrey
Journal: Journal of Hepatology (2006)
Confronting an Ill Society: David Widgery, General Practice, Idealism and the Chase for Change
Authors: Des Spence
Journal: BMJ (2005)

Patrick Hutt with Iona Heath and Roger Neighbour Radcliffe, £19.95, pp 144 1 85775 910 9 www.radcliffe-oxford.com/ Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> Did you ever have so much passion that you thought you might burst into flames? Do you remember staying up all night putting the world to rights and raging against the conservative establishment? What happened? You are now bored stupid living in the suburbs, driving a Teutonic monster, and musing about private schools. Your “radicalism” is confined to wearing surf gear at the weekend … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Pregnancy Experience Among Women With and Without Gestational Diabetes in the U.S., 1995 National Survey of Family Growth
Authors: Sharon H. Saydah, Anjani Chandra, Mark S. Eberhardt
Journal: Diabetes Care (2005)

OBJECTIVE—To compare the pregnancy experience among women with and without gestational diabetes mellitus (GDM) using a nationally representative survey. RESEARCH DESIGN AND METHODS—We analyzed data from the 1995 National Survey of Family Growth conducted by National Center for Health Statistics on 3,088 women age 15–44 years with at least one pregnancy between 1991 and 1995 to compare demographics, fecundity, and pregnancy experience by GDM (n = 116) or nondiabetes (n = 2,969) status. RESULTS—Among women with a pregnancy during 1991–1995, 3.6% reported GDM history. Women with GDM were older at age of delivery (31.8 years) than women without diabetes (29.0 years, P &amp;lt; 0.001). There was no significant difference between the groups by race/ethnicity. Compared with women without diabetes, women with gestational diabetes were more likely to report being currently surgically sterile (20.4 vs. 32.6%) or having impaired fecundity (12.6 vs. 19.7%, P &amp;lt; 0.001). GDM patients were more likely to have had a caesarean section than those without diabetes (31.7 vs. 20.9%, P = 0.02) and were more likely to report at least one of six additional nonroutine medical complications during pregnancy than nondiabetic patients (48.8 vs. 17.1%, P &amp;lt; 0.001). The odds ratio of a maternal medical complication during pregnancy for women with GDM compared with nondiabetic women, after adjusting for age at pregnancy and nongestational hypertension, was 4.3 (95% CI 2.7–6.8). CONCLUSIONS—These findings suggest that pregnancies in women with GDM are more likely to be associated with maternal medical complications compared with pregnancies in women without diabetes.
The Validity of the Equilateral Tetrahedron as a Spatial Reference System
Authors: J. A. ABILDSKOV, G. E. BURCH, J. A. CRONVICH
Journal: Circulation (1950)

The error involved in the use of the equilateral tetrahedron reference system for electrocardiographic or vectorcardiographic studies has been investigated by means of an electrical dipole placed in the esophagus. Vectors plotted from the potential differences between electrodes defining the reference system were found to correspond fairly closely to the actual position of the dipole, indicating that the error is small.
A simple method for biliary-enteric anastomosis and chronic bile diversion in the rat
Authors: Marek Rudnicki, David W. McFadden, Josef E. Fischer
Journal: Hepatology (1991)

A simple method of biliary-enteric anastomosis, without the use of surgical microscopy, is described. There were no signs of cholestasis after 3 mo of follow-up. A modified procedure using a silicone elastomer catheter as a stent for the biliary-enteric anastomosis resulted in biliary obstruction within 3 wk after surgery. Our experimental bile duct implantation technique is a simple and useful experimental method for the investigation of chronic biliary diversion and biliary physiology. Additionally, it can be performed safely and easily in a rodent model without sophisticated microscopic techniques. (HEPATOLOGY 1991;14:128-130.)
Indobufen in the prevention of thromboembolic complications in patients with heart disease. A randomized, placebo-controlled, double-blind study.
Authors: G Fornaro, P Rossi, P G Mantica, M E Caccia, D Aralda, M Lavezzari, F Pamparana, G Milanesi
Journal: Circulation (1993)

BACKGROUND The purpose of this randomized, double-blind study was to evaluate the efficacy of indobufen, a reversible inhibitor of platelet cyclooxygenase, in the prevention of embolic events of cardiac origin. METHODS AND RESULTS One hundred ninety-six patients with heart disease and at risk for cardiogenic embolism (90 with atrial fibrillation and 106 in sinus rhythm) were randomly assigned to receive indobufen (100 mg b.i.d.) or placebo. All patients were reexamined every 3 months for the duration of the study. The primary study end points were cerebral ischemic attack (stroke and transient ischemic attack), systemic embolism, pulmonary embolism, and fatal myocardial infarction. The median duration of treatment was 854 days in the indobufen group and 865 days in the placebo group. The frequencies of primary end points (fatal and nonfatal) were 6.1% and 17.3%, respectively, in the indobufen and placebo groups (p &lt; 0.05) for a reduction of 65% in the risk of a primary event (indobufen/placebo relative risk, 0.35; 95% confidence limits, 0.14-0.89). Adverse drug reactions, mostly gastrointestinal or hemostasis disorders, occurred in 9.2% of indobufen-treated patients. CONCLUSIONS The results of the study indicate that indobufen may reduce the risk of ischemic events in patients with heart disease associated with an increased risk of embolism.
Use and Abuse of Ambulation Aids
Authors: Robert H. Jebsen
Journal: JAMA (1967)

Because of the diversity of ambulation aids and gait patterns that are available, their prescription should be carefully thought out by the physician, taking into account the age and general condition of the patient as well as the specific disability. The aids chosen should be fitted to the patient by the physician or by a physical therapist, and the patient should receive instruction in their use, including climbing and descending stairs and techniques of sitting and arising. Preambulation exercises and training are often necessary for patients with severe disabilities. Patients should not be expected to learn safely and effectively to use ambulation aids without instruction.
Serum and Anaphylactic Reactions
Authors: D. A. Williams
Journal: BMJ (1955)

Almost any protein material or organic compound, by combining with body proteins, may produce severe allergic reactions.Although the use of serum and con- sequently the reactions from serum have been considerably reduced, these reactions still occur, and new treat- ments have brought new hazards.There are no more distressing emergencies than those which result from one's own treatment; their avoidance is most desirable, while their prompt recognition and treatment are essential.It is not the purpose of this paper to discuss reactions to those substances which are used only occasionally and which only very exceptionally cause reactions, but rather to those substances which the practitioner may well use often in the course of his work.Nor is the value, or otherwise, of serum sensitivity tests dealt with, as this subject was fully discussed by Laurent and Parish in a previous refresher-course series.*There are three main types of reactions: local reactions, anaphylactic reactions, and serum sickness.Local Reactions An area of local redness at the site of injection of an allergenic substance is not unusual and therefore gives rise to no concern, but when such reactions are large the gap between a local and a general reaction is being narrowed, and this must be remembered if further similar injections have to be given. Anaphylactic ReactionsAnaphylactic reactions always come on soon after the injection of the allergen, sometimes immediately, and the earlier the reaction the more likely is it to be severe and dangerous.A reaction occurring within a few minutes of the injection will be severe, and possibly fatal, while a reaction occurring after thirty minutes to an hour, although it may be quite troublesome, is rarely, if ever, dangerous.The earliest symptoms of severe and dangerous anaphylactic reactions may be sweating, a feeling of heat through- out the body, a generalized pruritus, or an urticarial rash rapidly becoming generalized; an irritating cough, dyspnoea and wheeziness, a choking sensation, substernal oppression, or a feeling of constriction in the chest; retching or vomit- ing with cramp-like pains in the abdomen, sometimes diarrhoea, occasionally severe abdominal distension; and/or headache, giddiness, or sudden unconsciousness, in some cases followed by convulsions; while acute circulatory col-
Thrombotic Thrombocytopenic Purpura Associated with Ticlopidine: A Review of 60 Cases
Authors: Charles L. Bennett
Journal: Annals of Internal Medicine (1998)

Background: Thrombotic thrombocytopenic purpura, a life-threatening multisystem disease, has been infrequently associated with use of ticlopidine, a platelet anti-aggregating agent. Purpose: To review 60 cases of ticlopidine-associated thrombotic thrombocytopenic purpura. Data Sources: Medical records, published case reports, and case reports submitted to the U.S. Food and Drug Administration. Study Selection: Instances of ticlopidine-associated thrombotic thrombocytopenic purpura were identified. Data Synthesis: Ticlopidine had been prescribed for less than 1 month in 80% of the patients, and normal platelet counts had been found within 2 weeks of the onset of thrombotic thrombocytopenic purpura in most patients. Mortality rates were higher among patients who were not treated with plasmapheresis than among those who underwent plasmapheresis (50% compared with 24%; P < 0.05). Conclusions: Ticlopidine use may be associated with the development of thrombotic thrombocytopenic purpura, usually within 1 month of initiation of therapy. The onset of ticlopidine-associated thrombotic thrombocytopenic purpura is difficult to predict, despite close monitoring of platelet counts.
Determination of terbinafine in nail samples during systemic treatment for onychomycoses
Authors: P.J. DYKES, R. THOMAS, A.Y. FINLAY
Journal: British Journal of Dermatology (2006)

A combination of alkali treatment and proteinase K digestion was used to solubilize nail samples from patients with onychomycosis treated orally with terbinafine. The samples were extracted and the levels of terbinafine and its metabolite measured by high-pressure liquid chromatography. The results showed a relatively rapid penetration of terbinafine into normal nail plate, suggesting that diffusion via the nail plate is the primary route of entry into this tissue. The levels of terbinafine achieved in nail samples exceeded the range of MICs for dermatophytes at the earliest time point (4 weeks) tested in 50% of patients and remained stable, without accumulation, during periods of treatment of up to 3 months.
Dosage-Sensitive, Reciprocal Genetic Interactions between the Abl Tyrosine Kinase and the Putative GEF trio Reveal trio 's Role in Axon Pathfinding
Authors: Eric C Liebl, David J Forsthoefel, Lara S Franco, Sandra H Sample, Jon E Hess, Jennifer A Cowger, Matthew P Chandler, Angela M Shupert, Mark A Seeger
Journal: Neuron (2000)
Tissue Engineering Approaches Utility
Authors: Mike Mitka
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-317 Systematic detection of coronary vasospasm by methylergonovine-based provocative test in 2,397 patients
Authors: Helene Aelion, Julien Rosencher, Marie Caroline Chenilleau, Stephane Manzo-Silberman, Philippe Allouch, Arnaud Jegou, Naim Bouazza, Alain Cariou, Olivier Varenne
Journal: Journal of the American College of Cardiology (2014)