The Diabetes Prevention Program and the Metabolic Syndrome
Authors: Priscilla S. Sarinas, Daniel S. Dube
Journal: Annals of Internal Medicine (2005)

Letters4 October 2005The Diabetes Prevention Program and the Metabolic SyndromePriscilla S. Sarinas, MD and Daniel S. Dube, MDPriscilla S. Sarinas, MDFrom VA Palo Alto Health Care System and Stanford University, Palo Alto, CA 94304.Search for more papers by this author and Daniel S. Dube, MDFrom VA Palo Alto Health Care System and Stanford University, Palo Alto, CA 94304.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-7-200510040-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:With respect to the study by Orchard and colleagues (1), several other studies have also suggested that sleep-related breathing disorder is independently associated with insulin resistance, endothelial dysfunction, and hypertension (2). Furthermore, impaired glucose tolerance seems to be related to the severity of oxygen desaturation associated with sleep-related breathing disorder independently of age, sex, body mass index, and waist circumference, and may be mediated by elevated release of epinephrine (2, 3). These abnormalities are corrected with positive-pressure ventilation (4). Thus, sleep is a “missing link” that should be included as a variable of syndrome X (5). Notwithstanding ...References1. Orchard TJ, Temprosa M, Goldberg R, Haffner S, Ratner R, Marcovina S, et al. The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial. Ann Intern Med. 2005;142:611-9. [PMID: 15838067] LinkGoogle Scholar2. Punjabi NM, Shahar E, Redline S, Gottlieb DJ, Givelber R, Resnick HE, et al. Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am J Epidemiol. 2004;160:521-30. [PMID: 15353412] CrossrefMedlineGoogle Scholar3. Oltmanns KM, Gehring H, Rudolf S, Schultes B, Rook S, Schweiger U, et al. Hypoxia causes glucose intolerance in humans. Am J Respir Crit Care Med. 2004;169:1231-7. [PMID: 15044204] CrossrefMedlineGoogle Scholar4. Babu AR, Herdegen J, Fogelfeld L, Shott S, Mazzone T. Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea. Arch Intern Med. 2005;165:447-52. [PMID: 15738376] CrossrefMedlineGoogle Scholar5. Coughlin SR, Mawdsley L, Mugarza JA, Calverley PM, Wilding JP. Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J. 2004;25:735-41. [PMID: 15120883] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Priscilla S. Sarinas, MD; Daniel S. Dube, MDAffiliations: From VA Palo Alto Health Care System and Stanford University, Palo Alto, CA 94304.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized Trial Trevor J. Orchard , Marinella Temprosa , Ronald Goldberg , Steven Haffner , Robert Ratner , Santica Marcovina , and Sarah Fowler , for the Diabetes Prevention Program Research GroupThe Diabetes Prevention Program and the Metabolic Syndrome Frank A. Anania , Samir Parekh , and Aasma Shaukat The Diabetes Prevention Program and the Metabolic Syndrome Trevor J. Orchard , Marinella Temprosa , and Robert Ratner Metrics Cited byEvaluating a small change approach to preventing long term weight gain in overweight and obese adults — Study rationale, design, and methods 4 October 2005Volume 143, Issue 7Page: 544-545KeywordsBreathingExerciseHypertensionInsulin resistanceMetabolic syndromeNutritionObesityOxygenProteinsSleep ePublished: 4 October 2005 Issue Published: 4 October 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...