tbuckley/cabot-search huggingface dataset:
Long-Term Outcome in Asymptomatic Men with Exercise-Induced Premature Ventricular Depolarizations
Authors: X Jouven, M Zureik, M Desnos, D Courbon, P Ducimetière
Journal: New England Journal of Medicine (2000)

Exercise testing is widely used in the diagnosis of coronary artery disease, but the long-term outcome for asymptomatic persons with exercise-induced premature ventricular depolarizations remains unclear. We used data from the Paris Prospective Study I to assess the long-term outcome for such persons.A total of 6101 asymptomatic French men (42 to 53 years of age) who were free of clinically detectable cardiovascular disease underwent a standardized graded exercise test between 1967 and 1972. Subjects were prospectively classified as having or not having frequent premature ventricular depolarizations (a run of two or more consecutive premature ventricular depolarizations or premature ventricular depolarizations constituting more than 10 percent of all ventricular depolarizations during any of the 30-second electrocardiographic recordings).During exercise, 138 subjects had frequent premature ventricular depolarizations. After 23 years of follow-up, these subjects had a higher risk of death from cardiovascular causes than the men without frequent premature ventricular depolarizations during exercise (relative risk, 2.67; 95 percent confidence interval, 1.76 to 4.07). In a multivariate model, with adjustment for age, body-mass index, heart rate at rest, systolic blood pressure, tobacco use, level of physical activity, presence or absence of diabetes, total cholesterol level, and the presence or absence of premature ventricular depolarizations before exercise and during recovery from exercise, both an exercise test that was positive for ischemia and the occurrence of frequent premature ventricular depolarizations during exercise remained independently associated with an increased risk of death from cardiovascular causes, with similar relative risks (2.63 [95 percent confidence interval, 1.93 to 3.59] and 2.53 [95 percent confidence interval, 1.65 to 3.88], respectively).The occurrence of frequent premature ventricular depolarizations during exercise in asymptomatic middle-aged men is associated with a long-term increase in the risk of death from cardiovascular causes.
Hypersensitivity to mustard seed
Authors: A. Malet, A. Valero, M. Lluch, M. Bescos, P. Amat, E. Serra
Journal: Allergy (1993)

Two patients were studied. Both underwent a thorough clinical evaluation, including a comprehensive physical examination. Both were also prick tested for inhalants, pollens, and food (including fruit). A nasal provocation test, serum immunoglobulins, total IgE serum, specific IgE serum, and a histamine release test were also carried out. The results of all these tests were positive to mustard seed.
Human Immunodeficiency Virus Infection in Diabetic Intravenous Drug Users
Authors: Kenrad E. Nelson, David Vlahov, Sylvia Cohn, Arlette Lindsay, Lisa Solomon, James C. Anthony
Journal: JAMA (1991)

--To evaluate the association between diabetes and human immunodeficiency virus (HIV) seroprevalence in a population of intravenous (IV) drug users.--Cross-sectional survey in a cohort of IV drug users.--Community-based study clinic.--The study included 2921 individuals with a history of IV drug use in the past 10 years; over 90% had injected drugs in the past year and 77% in the past month; only 15% were receiving drug treatment.--The HIV seroprevalence among IV drug users with and without a history of diabetes.--Those IV drug users with a history of diabetes had significantly lower HIV seroprevalence (9.8%) than nondiabetic IV drug users (24.3%; P = .03). Despite similar duration and intensity of drug use and sexual practices, diabetic IV drug users tended not to share injection paraphernalia and were less likely to attend shooting galleries than nondiabetic IV drug users.--Our data suggest that the apparent protective effect of diabetes against HIV infection in IV drug users is most likely due to their safer injection practices afforded by their ready access to sterile injection equipment.
Thiamine concentrations in liver disease.
Authors: S H Anderson, A D Nicol
Journal: BMJ (1984)

process is not yet possible.Perhaps this is still the case, despite the implications of Mr Waddell and others, for many cases of low back pain; for instance it would be interesting to know whether, taking the figures they quote, the 3700 of those undergoing surgery for sciatica who were found to have normal discs but obtained complete relief were experiencing more than a placebo effect.Also rather than seeing illness behaviour and disease processes in hierarchical terms, as they suggest, it might be more helpful to consider them as interacting processes.I believe it is only in this way that it will be possible to understand many psychosomatic disorders-for example, anorexia nervosa- and also many cases of low back pain.
A Salaried Service
Authors: G. L. McCulloch
Journal: BMJ (1965)

<h3>Abstract</h3> <b>Objective:</b> To investigate patients9 agendas before consultation and to assess which aspects of agendas are voiced in the consultation and the effects of unvoiced agendas on outcomes. <b>Design:</b> Qualitative study. <b>Setting:</b> 20 general practices in south east England and the West Midlands. <b>Participants:</b> 35 patients consulting 20 general practitioners in appointment and emergency surgeries. <b>Results:</b> Patients9 agendas are complex and multifarious. Only four of 35 patients voiced all their agendas in consultation. Agenda items most commonly voiced were symptoms and requests for diagnoses and prescriptions. The most common unvoiced agenda items were: worries about possible diagnosis and what the future holds; patients9 ideas about what is wrong; side effects; not wanting a prescription; and information relating to social context. Agenda items that were not raised in the consultation often led to specific problem outcomes (for example, major misunderstandings), unwanted prescriptions, non-use of prescriptions, and non-adherence to treatment. In all of the 14 consultations with problem outcomes at least one of the problems was related to an unvoiced agenda item. <b>Conclusion:</b> Patients have many needs and when these are not voiced they can not be addressed. Some of the poor outcomes in the case studies were related to unvoiced agenda items. This suggests that when patients and their needs are more fully articulated in the consultation better health care may be effected. Steps should be taken in both daily clinical practice and research to encourage the voicing of patients9 agendas
THE RELATION OF RADIOLOGY TO OTHER BRANCHES OF MEDICAL PRACTICE
Authors: ARTHUR C. CHRISTIE
Journal: JAMA (1931)

Radiology is the youngest branch of medicine. The roentgen ray was discovered in 1895 and radium in 1897. Many of the pioneers in their use in diagnosis and therapy are still in active practice. The entire history of radiology therefore covers a period of only about thirty-five years. Its progress has been so rapid that no hospital is now complete without a roentgenray department and there is scarcely a physician who does not at times make use of the roentgen ray in diagnosis and of both the roentgen ray and radium in the treatment of disease. Since these agents have become so widely used and so thoroughly established, the question is constantly arising as to the proper relationship of radiology to other branches of medical practice. Is it a special branch of medicine to be practiced by specialists in that field or is it simply a new armament which may
Influence of a 60-hour fast on insulin-mediated splanchnic and peripheral glucose metabolism in humans.
Authors: O Björkman, L S Eriksson
Journal: Journal of Clinical Investigation (1985)

A brief period of starvation (2-3) depletes the hepatic glycogen stores but results in only a limited reduction of the muscle glycogen depots. In this situation insulin resistance contributes to the glucose intolerance, but it is not known which tissue or tissues are responsible for the decreased insulin sensitivity. The present study was therefore undertaken to examine the influence of a 60-h fast on insulin sensitivity in splanchnic and peripheral tissues in normal humans. Euglycemic (95 mg/dl) 1-mU insulin and hyperglycemic (215-225 mg/dl) glucose clamp studies were conducted for 2 h in overnight (12 h) and prolonged (60 h) fasted nonobese subjects. Splanchnic exchange of glucose and gluconeogenic precursors was measured using the hepatic vein catheter technique. During the euglycemic clamp, insulin infusion resulted in similar steady state insulin levels in 60-h and 12-h fasted subjects (73 +/- 7 vs. 74 +/- 5 microU/ml). Total glucose disposal was reduced by 45% after 60 h of fasting (4.0 +/- 0.3 vs. 7.6 +/- 1.1 mg/kg per min, P less than 0.05) and the splanchnic glucose balance reverted from a net release in the basal state (12 h fast, -1.7 +/- 0.2, and 60-h fast, -0.9 +/- 0.1 mg/kg per min, P less than 0.01) to a net uptake during the clamps that was similar after 60 h and 12 h of fasting (0.6 +/- 0.1 vs. 0.6 +/- 0.2 mg/kg per min). During the hyperglycemic clamp, insulin levels rose rapidly in all subjects. In the 12-h fasted group this rise was followed by a further gradual one, reaching significantly higher values than in 60-h fasted subjects during the second hour (67 +/- 15 vs. 25 +/- 2 microU/ml, P less than 0.05). Total glucose disposal was lower, though not significantly so, after the 60-h fast (2.6 +/- 0.4 vs. 5.4 +/- 1.3 mg/kg per min, 0.05 less than P less than 0.10), and as with the euglycemic clamp, the splanchnic glucose balance was altered from a basal net release to a net uptake during the clamp (1.3 +/- 0.2 vs. 1.1 +/- 0.2 mg/kg per min). After an overnight fast, splanchnic lactate uptake fell and the arterial lactate concentration rose in response to both hyperglycemia and hyperinsulinemia, whereas these variables were unchanged in the 60-h fasted subjects during both types of clamp studies.
Computer-assisted image analysis of skin surface replicas
Authors: RUTH MURPHY, D. W. K. COTTON, A. L. WRIGHT, S. S. BLEEHEN
Journal: British Journal of Dermatology (1991)

Journal Article Computer‐assisted image analysis of skin surface replicas Get access RUTH MURPHY, RUTH MURPHY University Departments of Pathology and *Dermatology, Royal Hallamshire Hospital, Sheffield, U. K. Search for other works by this author on: Oxford Academic Google Scholar D. W. K. COTTON, D. W. K. COTTON University Departments of Pathology and *Dermatology, Royal Hallamshire Hospital, Sheffield, U. K. Ur D. W. K. Cotton, Department of Pathology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, U. K. Search for other works by this author on: Oxford Academic Google Scholar A. L. WRIGHT, A. L. WRIGHT University Departments of Pathology and *Dermatology, Royal Hallamshire Hospital, Sheffield, U. K. Search for other works by this author on: Oxford Academic Google Scholar S. S. BLEEHEN S. S. BLEEHEN University Departments of Pathology and *Dermatology, Royal Hallamshire Hospital, Sheffield, U. K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 6, 1 June 1991, Pages 571–575, https://doi.org/10.1111/j.1365-2133.1991.tb04953.x Published: 01 June 1991
Imipramine in Parkinsonism
Authors: J. S. Price
Journal: BMJ (1965)

JBoiUA 169 signs of any abnormality in the central nervous system.The blood-pressure was known to have been within normal limits previously.The patient was put to bed and sedated, but it was later found that she could not be roused; when seen again by her doctor two hours after the first examination she was comatose, with a blood-pressure of 170/100 mm.Hg; the patient was sent to hospital, but died very shortly after admission.Post-mortem examination showed a haemor- rhage in the left cerebral hemisphere disrupting the internal capsule and adjacent areas of the left corpus striatum.No other abnormality was found-in particular, no intracranial aneurysms -and no evidence of long-standing hypertension.-We are, etc.,
The Luminous Autumn — The<i>Journal</i>and Joseph Garland
Authors: Robert O'Leary
Journal: New England Journal of Medicine (1967)

BEING particularly applicable to the subject at hand, the portion of the title given above in quotations is borrowed, with grateful acknowledgment, from Dr. Meir Yoeli's1 moving and inspiring account of Charles Nicolle's lectures at the Collège de France in the autumn of his years. The New England Journal of Medicine, in its hundred and fifty-fifth year of continuous publication, may surely be said to have reached the season of reflective maturity, and its retiring editor, no less surely, to have begun to break new ground at an age when most men are consolidating established positions and some are . . .
Successful Management of a Chronic, Refractory Bronchopleural Fistula with Endobronchial Valves followed by Talc Pleurodesis
Authors: William B. Cundiff, Francis X. McCormack, Kathryn Wikenheiser-Brokamp, Sandra Starnes, Robert Kotloff, Sadia Benzaquen
Journal: American Journal of Respiratory and Critical Care Medicine (2014)
Diurnal variations in the pH of pathological gallbladder bile.
Authors: D J Sutor, L I Wilkie
Journal: Gut (1976)

The pH of gallbladder and common duct bile from patients undergoing surgery for cholecystectomy has been measured. The bile was collected and kept anaerobically at 37 degrees C, and the pH measured at 37 degrees C, generally within 30-60 minutes of the bile being taken from the patient. Only data from patients having functioning or poorly-functioning gallbladders were included in the calculations. The pH of common duct bile was always greater than that of the corresponding gallbladder bile, and the data available suggest that it does not vary diurnally. The mean pH of gallbladder bile from patients undergoing their operation at different times during the day shows a diurnal variation, the bile becoming more acidic with time. Furthermore, there is also a diurnal variation in the activity of the acidifying process. Data for the patients suggest this is retarded by sleep, inactivity, or lying down.
Problem of Pulmonary Circulation
Authors: Lawrence C. Parish
Journal: JAMA (1962)

The study of pulmonary physiology is a fascinating subject; the Ciba Foundation, almost without exception, arranges outstanding conferences. The combination of the 2 has resulted in a worthwhile, succinct volume dealing with several important aspects of pulmonary circulation. These include: radiological evaluation of pulmonary arterial and venous pressures, pulmonary circulation in cardiac disease, pulmonary hypertension, nervous aspects of pulmonary circulation, gas exchange, and the results of varying oxygen tension and acetylcholine. I was particularly interested in the discussion of pulmonary hypoventilation in regard to local reflex action. P. H. Rossier of Zurich has concluded that pulmonary vascular constriction results in alveolar hypoventilation primarily due to the decreased oxygen tension and only secondarily to the elevated partial carbon dioxide pressure. Graphically, a linear relationship exists between the mean pulmonary arterial pressure and the alveolar oxygen tension. The peripheral arterial oxygen desaturation has no direct bearing on peripheral intrapulmonary vascular resistance. Lastly,
Emerging Technologies in Surgery
Authors: Hasan B. Alam
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nuclear Particles of Non-A, Non-B Type in Healthy Volunteers and Patients with Hepatitis B
Authors: Hanspeter Spichtin, Fred Gudat, Hans Berthold, Gunthild Krey, Martin Schmid, Mauro Pirovino, Josef Altorfer, Georg Stalder, Gerald Eder, Leonardo Bianchi
Journal: Hepatology (1984)

In an electron microscopic study, nuclear aggregates of virus-like spherical and tubular particles measuring 20 to 29 nm in diameter were found in 5 of 7 clinically healthy volunteers with normal liver histology, 6 of 10 patients with hepatitis B and 17 of 18 patients with hepatitis non-A, non-B. The incidence of hepatocytes containing nuclear particles was approximately 0.5 to 2% in all three groups. We conclude that these nuclear particles are not specific ultrastructural markers of hepatitis non-A, non-B in man as originally claimed for experimental hepatitis non-A, non-B in chimpanzees.
Resistance to HIV drugs in UK may be lower in some areas
Authors: Julie M Fox, Sarah Fidler, Jonathan Weber
Journal: BMJ (2006)

Editor—The UK Group on Transmitted HIV Drug Resistance reports an estimated prevalence of transmitted HIV drug resistance of 14.2% between 1996 and 2003 which is increasing over time.1 Using the same definition of drug resistance as the UK group, a study of primary HIV infection at St Mary's Hospital, London, showed that the prevalence and annual incidence of transmitted drug resistance have remained …
Targeting liver fibrosis: Strategies for development and validation of antifibrotic therapies
Authors: Yury Popov, Detlef Schuppan
Journal: Hepatology (2009)

We have made striking progress in our understanding of the biochemistry and cell biology that underlies liver fibrosis and cirrhosis, including the development of strategies and agents to prevent and reverse fibrosis. However, translation of this knowledge into clinical practice has been hampered by (1) the limitation of many in vitro and in vivo models to confirm mechanisms and to test antifibrotic agents, and (2) the lack of sensitive methodologies to quantify the degree of liver fibrosis and the dynamics of fibrosis progression or reversal in patients. Furthermore, whereas cirrhosis and subsequent decompensation are accepted hard clinical endpoints, fibrosis and fibrosis progression alone are merely plausible surrogates for future clinical deterioration. In this review we focus on an optimized strategy for preclinical antifibrotic drug development and highlight the current and future techniques that permit noninvasive assessment and quantification of liver fibrosis and fibrogenesis. The availability of such noninvasive methodologies will serve as the pacemaker for the clinical development and validation of potent antifibrotic agents. (Hepatology 2009.)
Sonnerie de Saint Genevieve du Mont
Authors: Carol V. Davis
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wolff-Parkinson-White Syndrome
Authors: ONKAR S. NARULA
Journal: Circulation (1973)

Recent developments in the field of electrophysiology and surgical therapy in selected cases of Wolff-Parkinson-White syndrome (W-P-W) support the concept of anomalous A-V pathways. Impulse transmission usually occurs simultaneously through both the normal and anomalous pathways resulting in a fusion QRS complex. Atrial tachycardia is usually due to reentry through the normal and anomalous A-V pathways. However, reentry may occur independently in the A-V node alone exclusive of the anomalous pathway. Anomalous connections, despite varying anatomic locations, may result in similar electrocardiographic manifestations characteristic of W-P-W. His bundle recordings together with electrophysiologic studies may be clinically useful (1) to differentiate various types of anomalous connections, (2) for possible determination of the reentry circuit, (3) to predict the maximum ventricular rate possible during supraventricular tachycardia by evaluating the refractory period of the A-V pathways, or (4) to compare the efficacy of different drugs in a given patient. Surgical interruption of the anomalous pathway in selected cases with W-P-W (type B) is feasible but is most commonly not necessary. The indications for medical and surgical management of symptomatic cases with W-P-W are reviewed.
Adiponectin Modulates the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway and Attenuates Mammary Tumorigenesis of MDA-MB-231 Cells in Nude Mice
Authors: Yu Wang, Janice B. Lam, Karen S.L. Lam, Jing Liu, Michael C. Lam, Ruby L.C. Hoo, Donghai Wu, Garth J.S. Cooper, Aimin Xu
Journal: Cancer Research (2006)

Abstract Adiponectin is an adipokine that has pleiotropic beneficial roles in systemic insulin resistance and inflammation. Several recent clinical studies suggest that low serum levels of adiponectin are associated with increased risks of breast cancer. Here, we investigated the direct effects of adiponectin on breast cancer development in vitro and in vivo. Our results showed that adiponectin significantly attenuated the proliferations of two typical human breast cancer cells, MDA-MB-231 and T47D, in a cell type–specific manner. Further analysis revealed that adiponectin could induce apoptosis and arrest the cell cycle progression at G0-G1 phase in MDA-MB-231 cells. Prolonged treatment with adiponectin in this cell line blocked serum-induced phosphorylation of Akt and glycogen synthase kinase-3β (GSK-3β), suppressed intracellular accumulation of β-catenin and its nuclear activities, and consequently reduced expression of cyclin D1. Adiponectin-mediated suppression of cyclin D1 expression and attenuation of cell proliferation was abrogated by the GSK-3β inhibitor lithium chloride. These results suggest that the inhibitory role of adiponectin on MDA-MB-231 cell growth might be attributed to its suppressive effects on the GSK-3β/β-catenin signaling pathway. Furthermore, our in vivo study showed that both supplementation of recombinant adiponectin and adenovirus-mediated overexpression of this adipokine substantially reduced the mammary tumorigenesis of MDA-MB-231 cells in female nude mice. Taken together, these data support the role of adiponectin as a negative regulator of breast cancer development and also suggest that adiponectin might represent a novel therapeutic target for this disease. (Cancer Res 2006; 66(23): 11462-70)