tbuckley/cabot-search huggingface dataset:
Pulmonary Intra- and Extravascular Fluid Volume Changes with Exercise
Authors: M. Korsgren, R. Luepker, B. Liander, E. Varnauskas
Journal: Cardiovascular Research (1969)

Pulmonary extravascular (PEV) and intravascular (PBV) volumes were simultaneously measured both at rest and exercise in five patients. Mean PEV increase from rest to exercise was 88%. This increase was related to PLA, but not PPA or PVR. No relationship between PEV and PBV could be demonstrated.
949. Oncolytic Autonomous Parvovirus (rH1-yCD) Targeting with P4/Carcinoembryonic Antigen Chimeric Promoter for Virotherapy of Pancreatic Cancer
Authors: Soukaina Rejiba, Marc Aprahamian, Amor Hajri
Journal: Molecular Therapy (2006)

Background: Successful gene therapy depends on the development of safe and efficient vectors for gene expression targeting. We investigated the use of a rH1CEA-yCD recombinant parvoviral vector, bearing the yeast cytosine deaminase (yCD) suicide gene. The parvoviral P4 promoter was modified by the addition of a 319 bp Carcinoembryonic Antigen (CEA) tissue-specific promoter sequence, to improve the oncotropic and oncolytic intrinsic properties of the autonomous H-1 parvovirus. Material & Methods: To this end, we explored in vitro, the ability of this rH1CEA-yCD virus to infect CEA-producing cell line (BxPc3) and CEA-nonproducing cell lines (HA-HPC and HeLa). The suicide gene expression was evaluated by RT-PCR and western blotting. The cytotoxicity effect was measured by MTT test. For in vivo experiments, we evaluated the oncolytic efficacy of this new recombinant parvovirus on tumor growth upon subcutaneous/ peritoneal pancreatic carcinomatosis models in nude mice. Results: Our data indicate that rH1CEA-yCD infect efficiently the tumor cell lines in the same manner as its parental rH1-yCD. RT-PCR and western blot analyses showed a down-regulation of the expression of both the NS1 (viral gene) and the yCD (suicide gene) brought by rH1CEA-yCD in HA-HPC and HeLa cell lines, when compared with rH1-yCD. With regard to its cytotoxic effect, rH1CEA-yCD/ 5-FC treatment was incapable to induce cell death in those cell lines, but was as efficient as rH1-yCD to kill BxPc3 cell line. In vivo, infection with rH1CEA-yCD led to significant retardation of BxPc3 tumor growth both in subcutaneous and intraperitoneal disseminated pancreatic models. The survival rate of animals bearing CEA-producing cell lines (BxPc3) was improved (p<0.001). However, there was no effect on HA-HPC tumor models. Conclusion: In summary, we have developed a new targeted recombinant parvovirus where the parvoviral oncolytic effect and the suicide gene expression are tightly restricted to tumor cells with CEA tumor marker promoter signaling.
Anginal-Type Pain and Pulmonary Artery Pressure
Authors: Solomon Fisch
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The conclusion advanced by Donna Zimmerman and Brent M. Parker, MD (1981;246:2345), that anginal-type pain is unrelated to pulmonary hypertension does not seem to have resolved the issue at all. Their retrospective study attempted to correlate anginal-type pain with pulmonary pressure measured during scheduled cardiac catheterization, while the patient was not experiencing pain. To transpose my argument to more familiar territory and with what we know today, would we not be seriously misguided if we established correlatives of pain by using resting electrical, nuclear, or hemodynamic measurements obtained during a pain-free period in patients with angina pectoris owing to coronary artery disease?
Endothelin and restenosis
Authors: M Kirchengast
Journal: Cardiovascular Research (1998)

Time for primary review 31 days

Percutaneous transluminal angioplasty (PTCA) was first introduced into the therapy of patients with coronary artery stenosis in the late seventies [1]. In the two decades since, this method has become standard therapy for patients suffering from all forms of coronary artery disease. The success rate of the procedure itself has increased from 61 percent in the late seventies to well over 90 percent from the mid-eighties onwards [2]. However, long-term success of PTCA remains limited by late restenosis caused by vessel wall proliferation that occurs in 20 to 40 percent of all patients to such an extent that a second PTCA is necessary [2]. As in the mid-90s about 500,000 primary PTCA procedures were carried out in the USA [3]and about 200,000 in Europe [4], this accounts for more than 230,000 patients per year eligible for a second invasive procedure due to recurrent angina. A hypothetical reduction of the incidence of restenosis by 10–15 percent per year would reduce annual treatment costs by almost 1.5 billion dollars in the USA and Europe alone. Up to now a large number of clinical trials performed to investigate whether systemic administration of drugs which were effective in animal models of restenosis were efficacious in men have failed. The reason for this discrepancy between pre-clinical and clinical studies could be that doses effective in experimental settings have not been applicable to patients due to other cardiovascular effects of these drugs [5]. If technical advances, such as the use of stents, will by themselves be able to achieve the goal of a significant reduction of restenosis rates long term still needs to be studied. Two clinical trials with 6 months follow up have been published, both showing a reduction in restenosis [6, 7] … 

* Corresponding author. Tel.: +49 (621) 589 2879; Fax: +49 (621) 589 3551; E-mail: michael.kirchengast@knoll-ag.de
Successful treatment of acrodermatitis continua of Hallopeau by the tumour necrosis factor-alpha inhibitor infliximab (RemicadeR)
Authors: R. Mang, T. Ruzicka, H. Stege
Journal: British Journal of Dermatology (2004)

Sir, Acrodermatitis continua of Hallopeau (ACH) is characterized by chronic, recurrent pustular acral eruptions, involving the distal phalanges of the hands and feet.1 Atrophic skin changes, onychodystrophy and osteolysis are frequently present, causing painful and disabling lesions. The aetiology and pathomechanism of ACH are still unknown. Because of its histological features most authors consider ACH as a variant of pustular palmoplantar psoriasis which, in contrast to other forms, is recalcitrant to most antipsoriatic drugs.2, 3 We report the first case of successful treatment of ACH with the new tumour necrosis factor (TNF)‐α inhibitor infliximab. A 58‐year‐old man presented with a 4‐year history of persistent nail dystrophy. He first noted erythematous confluent pustules forming plaques on his fingertips, then, within weeks, paronychial and subungual involvement occurred on all fingers and subsequently led to nail dystrophy. Erythematosquamous, psoriasiform lesions were observed on the dorsal aspect of the terminal phalanges (Fig. 1A). No other skin lesions were observed elsewhere. Microbiological examination of pustular lesions revealed no infection. Histological features of psoriasis were found in biopsy specimens from lesional skin. X‐ray examination revealed no osteolytic changes of the bones or joint deformities. Previous therapeutic regimens such as topical and systemic glucocorticosteroids, calcipotriol, antibiotics and oral acitretin did not show any effects. Ciclosporin gave initial improvement of the acral lesions, but had to be discontinued after 6 months because of side‐effects and loss of effect.
Calcitriol Treatment Is Not Effective in Postmenopausal Osteoporosis
Authors: Susan M. Ott
Journal: Annals of Internal Medicine (1989)

Study Objective: To determine if calcitriol is an effective treatment in postmenopausal osteoporosis. Design: Double-blind, randomized clinical trial of 2 years' duration. Setting: University medical center with patients recruited by media announcements. Patients: Eighty-six postmenopausal women with vertebral compression fractures. Interventions: Patients were treated with calcitriol or placebo. Mean dose was 0.43 µg/d. Dietary calcium was 1000 mg/d (24.9 mmol/d). The medication dose and dietary calcium were adjusted for hypercalciuria or hypercalcemia. Measurements and Main Results: No significant differences between placebo and control groups were seen in the percent change in total body calcium (0.4% ± 1.0 compared with 0.0% ± 0.9), single photon absorptiometry (-0.5% ± 1.2 compared with -3.1% ± 0.9) or dual photon absorptiometry (0.0% ± 1.7 compared with -1.0% ± 2.2). New fractures were seen in 16% of the placebo group and 26% of the calcitriol group, so the difference in percent fractures was 10% (95% CI, -5.7% to 25.7%). Bone biopsies did not show changes in either group. The calcitriol group had significantly higher serum and urine calcium values, but renal function was not worse than in the placebo group. Conclusions: Calcitriol is not an effective treatment for established postmenopausal osteoporosis.
Abuse of fresh frozen plasma.
Authors: R V Majer, P J Green, P Weir
Journal: BMJ (1987)

peak plasma insulin value was reached 15 minutes after glucose injection.These findings lead us to conclude that intra- venous administration of hypertonic solutions such as glucose 40%, but probably also radio- graphic contrast media, may cause a fall of blood pressure in the elderly, probably through direct vasodilatation.Secondly, the endogenous insulin response to glucose 40% given intravenously elicited no effect on blood pressure in the elderly.
Temporal Pattern of Ischemic Events in Relation to Dual Antiplatelet Therapy in Patients With Unprotected Left Main Coronary Artery Stenosis Undergoing Percutaneous Coronary Intervention
Authors: Tullio Palmerini, Antonio Marzocchi, Corrado Tamburino, Imad Sheiban, Massimo Margheri, Giuseppe Vecchi, Giuseppe Sangiorgi, Andrea Santarelli, Antonio L. Bartorelli, Carlo Briguori, Luigi Vignali, Francesco Di Pede, Angelo Ramondo, Luigi Inglese, Marco De Carlo, Leonardo Bolognese, Alberto Benassi, Cataldo Palmieri, Vincenzo Filippone, Diego Sangiorgi, Fabio Barlocco, Giulia Lauria, Stefano De Servi
Journal: Journal of the American College of Cardiology (2009)
Epidemiology of Burns
Authors: John D. MacArthur
Journal: JAMA (1975)

Predisposition to burning was identified by history, by conversation with the family, or by physical examination. Factors that decreased the patient's ability to respond appropriately were considered as predisposing. A consecutive series of 155 hospitalized, burned, adult patients was reviewed. Approximately 50 per cent of the entire series showed predisposition to burning; among the more severe burns, this fraction was 57 percent. Among women, predisposition was more prominent in all categories than among men. Among women, those predisposed to burning had larger burns and a greater likelihood of dying. Alcoholism led the list of predisposing factors, with senility, psychiatric disorders, and neurological disease following in order. The patient's own home was usually the site of the burn in those predisposed, with the initial ignition being in the patient's hair or clothing, the mattress, bedclothes, or an overstuffed chair. All of the burns occurring in hospital or mental institution patients were among those predisposed to burning.
Melanonychia, melanocytic hyperplasia, and nail melanoma in a Hispanic population
Authors: Judith Dominguez-Cherit, Rodrigo Roldan-Marin, Patricia Pichardo-Velazquez, Celeste Valente, Veronica Fonte-Avalos, Maria Elisa Vega-Memije, Sonia Toussaint-Caire
Journal: Journal of the American Academy of Dermatology (2008)
Abstract 4199: CDKN2A/p16INK4a 5′UTR variants in melanoma predisposition: Lost in translation, somewhere
Authors: Alessandra Bisio, Virginia Andreotti, Elisa Latorre, Valerio Del Vescovo, Yari Ciribilli, Alessandro Provenzani, Alessandro Quattrone, Giovanna Bianchi-Scarra', Michela A. Denti, Paola Ghiorzo, Alberto Inga
Journal: Cancer Research (2012)

Abstract The CDKN2A gene is the most common high penetrance susceptibility gene identified to date in melanoma families. While functional tests for determining the pathogenicity of missense germline mutations in the CDKN2A coding region have been developed, rare polymorphisms or sequence variants at the CDKN2A/ p16INK4a 5′UTR, encountered during routine screening, are usually defined as variants with unknown significance after determining their frequency in control population and the cosegregation analysis in the family, when possible. We recently developed reporter assays to study a panel of p16INK4a 5′UTR variants identified as heterozygous changes in patients from a hospital-based series of melanoma cases (c.-21C&amp;gt;T; c.-25C&amp;gt;T&amp;c.-180G&amp;gt;A; c.-56G&amp;gt;T; c.-67G&amp;gt;C). Monocistronic as well as bicistronic luciferase-based reporter vectors were developed and used to test wild type and variant p16INK4a 5′UTR activity upon transient transfection in melanoma-derived cells (WM266-4, G361 and SK-Mel-5) and in the breast cancer-derived MCF7 cells. Results revealed that the c.-21C&amp;gt;T variant had a strong negative impact on the reporter activity, similar to that of the known melanoma-predisposing mutation c.-34G&amp;gt;T, included as a control. The variants at –56 and at –25&amp;-180 exhibited a milder impact, while results with c.-67G&amp;gt;C were dependent on the type of reporter vector. Quantification of the luciferase mRNA conducted in parallel with the luciferase assay indicated that the impact of the variants was mainly post-transcriptional. We also applied a polysomal profiling technique to measure allelic imbalance starting from heterozygous patient-derived cell lines and found that the c.-21C&amp;gt;T variant but also c.-56T&amp;gt;G and c.-67G&amp;gt;C exhibited lower association with the polysomes suggestive of reduced mRNA translation efficiency. A panel of eleven additional germline variants in the 5′UTR of p16INK4a is being investigated. In particular we are focusing on the functional interactions between wild type and variant p16INK4a 5′- and 3′-UTR sequences and on the impact the variants can have on the targeting of the p16INK4a mRNA by microRNAs (including mir-346, -636, -639, -935) or RNA binding proteins (including YB-1). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4199. doi:1538-7445.AM2012-4199
Molecular biology and respiratory disease. 4. Cancer genes.
Authors: K Sikora, G Ong
Journal: Thorax (1990)

Bronchial carcinoma is one of the most com- mon malignant tumours and its incidence continues to rise.Although smoking and other environmental factors remain risk factors, little is known about its genesis.Treatment, other than surgery or radiotherapy for local disease, is rarely curative and remains at best palliative.With the incidence of lung cancer continu- ing to rise, ways of predicting susceptibility and new therapeutic approaches are urgently required.The techniques of molecular biology have started to clarify some of the mechanisms of tumorigenesis and tumour growth.The application of these techniques to lung cancer has enormous potential and should make a major contribution to the man- agement of this disease.In this article we review some of the recent advances in our understanding of the mechan- isms of tumour development and growth.The problems of disordered growth are not limited to one tumour type, and our information now comes from many studies on a wide range of tumour types.
Immunoblastic lymphadenopathy. Patient with prolonged fever of unknown origin
Authors: B. K. MacDougall
Journal: JAMA (1979)

IMMUNOBLASTIC lymphadenopathy, first described by Lukes and Tindle<sup>1</sup>in 1973, is characterized by fevers, sweats, weight loss, rash, pruritus, lymphadenopathy, and hepatosplenomegaly. Other features include hypergammaglobulinemia, hemolytic anemia, positive Coomb's reaction, and a history of drug hypersensitivity. We recently saw a patient with a ten-month history of recurrent fever of unknown origin in whom multiple cultures, lymph node biopsy specimens, and a laparotomy were initially nondiagnostic. <h3>Report of a Case</h3> A 36-year-old woman was admitted to the hospital on April 6, 1975, with a one-week history of fever, shortness of breath, and general malaise. She was acutely dyspneic and febrile (39 °C) and had bibasilar rales but no lymphadenopathy, hepatosplenomegaly, or skin rash. Her hemoglobin level was 12 g/dl, and her WBC count was 9,500/cu mm, with 91% polymorphonuclear leukocytes, 7% lymphocytes, and 2% eosinophils. The liver enzyme levels were normal. The initial chest roentgenogram showed a moderately
High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes.
Authors: S E Bursell, A C Clermont, L P Aiello, L M Aiello, D K Schlossman, E P Feener, L Laffel, G L King
Journal: Diabetes Care (1999)

OBJECTIVE: To determine the effectiveness of vitamin E treatment in normalizing retinal blood flow and renal function in patients with &amp;lt;10 years of type 1 diabetes. RESEARCH DESIGN AND METHODS: An 8-month randomized double-masked placebo-controlled crossover trial evaluated 36 type 1 diabetic and 9 nondiabetic subjects. Subjects were randomly assigned to either 1,800 IU vitamin E/day or placebo for 4 months and followed, after treatment crossover, for a further 4 months. Retinal blood flow was measured using video fluorescein angiography, and renal function was assessed using normalized creatinine clearance from timed urine collections. RESULTS: After vitamin E treatment, serum levels of vitamin E were significantly elevated (P&amp;lt;0.01) in both type 1 diabetic and control patients. Hemoglobin A1c was not affected by vitamin E treatment. Diabetic patient baseline retinal blood flow (29.1+/-7.5 pixel2/s) was significantly (P = 0.030) decreased compared with that of nondiabetic subjects (35.2+/-7.2 pixel2/s). After vitamin E treatment, diabetic patient retinal blood flow (34.5+/-7.8 pixel2/s) was significantly increased (P&amp;lt;0.001) and was comparable with that of nondiabetic subjects. Additionally, vitamin E treatment significantly (P = 0.039) normalized elevated baseline creatinine clearance in diabetic patients. CONCLUSIONS: Oral vitamin E treatment appears to be effective in normalizing retinal hemodynamic abnormalities and improving renal function in type 1 diabetic patients of short disease duration without inducing a significant change in glycemic control. This suggests that vitamin E supplementation may provide an additional benefit in reducing the risks for developing diabetic retinopathy or nephropathy.
Abstract 1689: Impact of pre-treatment body mass index on patients with head and neck cancer treated with radiation
Authors: Ngan M. Tsang
Journal: Cancer Research (2012)

Abstract Purpose: Radiation therapy (RT) may lead to difficulty in swallowing and subsequently weight loss in patients with head and neck cancer. We investigated the association of pre-treatment body mass index (preT BMI) with outcomes of head and neck cancer in patients treated with radiation. Methods: All 1562 patients diagnosed with head and neck cancer and treated with curative-intent RT to a dose of 60Gy or higher between 1994 and 2004 were retrospectively studied. Body weight was measured both at entry and at the end of RT. cancer-specific survival (CSS), overall survival (OS), locoregional control (LRC) and distant metastasis (DM) were analyzed by preT BMI (&amp;lt; 25 Kg/m2 vs ≤ 25Kg/m2). The median follow-up was 8.6 years. Results: Patients with higher preT BMI appeared to have earlier T and N stage. Patients with lower preT BMI were statistically significantly associated with poor CSS (p = 0.023) and OS (p &amp;lt; 0.0001) than those with higher preT BMI. There is no significant difference between high and low preT BMI in LRC and DM. Body weight loss (BWL) during radiation did not influence survival outcomes. However, in the group of higher preT BMI, CSS, OS and DM-free survival of patients with less BWL during radiation was statistically longer when compared with greater BWL (p = 0.002, &amp;lt; 0.0001, and 0.033). Conclusion: This study demonstrates preT BMI greater than or equal to 25 Kg/m2 positively influenced survival outcomes for patients with head and neck cancer. Patients with higher preT BMI who were able to maintain their weight during radiation had significantly better survival and distant outcomes than patients experiencing greater BWL. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1689. doi:1538-7445.AM2012-1689
Metastatic Insulinoma Treated with Streptozotocin
Authors: PAUL H. SCHREIBMAN
Journal: Annals of Internal Medicine (1971)

A patient with hepatic metastases of an insulin-producing islet cell carcinoma has been successfully treated with streptozotocin. At 6 months posttreatment, liver scans demonstrate complete regression of tumor, and blood glucose and insulin levels have returned to normal. The pharmacology of and indications for streptozotocin (a 1-methyl, nitrosourea-glucosamine antitumor antibiotic) are discussed.
1052 ANTIVIRAL ACTIVITY OF FILIBUVIR IN COMBINATION WITH PEGYLATED INTERFERON ALFA-2A AND RIBAVIRIN FOR 28 DAYS IN TREATMENT NAIVE PATIENTS CHRONICALLY INFECTED WITH HCV GENOTYPE 1
Authors: I. Jacobson, P. Pockros, J. Lalezari, E. Lawitz, M. Rodriguez-Torres, E. DeJesus, F. Haas, C. Martorell, R. Pruitt, K. Durham, S. Srinivasan, M. Rosario, S. Jagannatha, J. Hammond
Journal: Journal of Hepatology (2009)
Receptor mediated presynaptic modulation of the release of noradrenaline in human papillary muscle
Authors: I. Matko, E. Feher, E S. Vizi
Journal: Cardiovascular Research (1994)

Objective: The aim was to determine the presynaptic modulation of noradrenaline (NA) release from the sympathetic nerve terminals in human isolated papillary muscle. Methods: Papillary muscle and the right atrial appendage were obtained from operations on 22 patients (10 men and 12 women). The papillary muscle preparations were preincubated with [3H]NA and the release of [3H] at rest and in response to field stimulation was measured. Results: Using an immunohistochemical method dopamine-β-hydroxylase-positive neurones were found in the papillary muscle and right atrial appendage sample. The release of noradrenaline from the papillary muscle, associated with axonal activity, was enhanced by 7,8(methylenedioxy)-14-α-hydroxyalloberbane HC1 (CH-38083). a selective α2 adrenoceptor antagonist, and inhibited by xylazine, an α2 adrenoceptor agonist, indicating that negative feedback modulation was functioning. In addition, the release of [3H]NA was enhanced by atropine, pancuronium, and 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP), a selective M3muscarinic receptor antagonist, and reduced by oxotremorine, a selective muscarinic receptor agonist, indicating that acetylcholine released from the parasympathetic nerve ending was able to reach the varicose noradrenergic axon terminals that are equipped with inhibitory M3 muscarinic receptors. Conclusions: These findings, obtained for the first time in human papillary muscle, indicate that the release of noradrenaline is modulated by α2 autoreceptors activated by noradrenaline and M, muscarinic heteroreceptors. Thus during parasympathetic stimulation the release of noradrenaline from the sympathetic axon terminals is presynaptically controlled through muscarinic receptors. Cardiovascular Research 1994;28:700-704