tbuckley/cabot-search huggingface dataset:
Feasibility of Management of High-Grade Cervical Lesions in a Single Visit
Authors: Wendy R. Brewster, F. Allan Hubbell, Joan Largent, Argyrios Ziogas, Fritz Lin, Susan Howe, Theodore G. Ganiats, Hoda Anton-Culver, Alberto Manetta
Journal: JAMA (2005)

The incidence of cervical cancer is higher among low-income and minority women who have never undergone a conventional Papanicolaou test or who do not follow up after testing. Screening has been shown to reduce cervical cancer incidence rates.To determine the feasibility and acceptability of immediately treating women with severely abnormal Papanicolaou test results by using a single-visit cervical cancer screening and treatment program and to compare treatment rates and 12-month follow-up rates with those of women who received usual care.Randomized controlled trial conducted among 3521 women aged 18 years or older recruited between January 1999 and April 2002 at US community health centers located in predominantly Latino underserved areas.Women randomized to usual care (n = 1805) were discharged immediately after examination. Women randomized to the single-visit group (n = 1716) remained at the clinic until the results of their conventional Papanicolaou test were available. Large loop electrosurgical excision procedure was performed in single-visit patients with either a diagnosis of a high-grade squamous intraepithelial lesion (HGSIL)/atypical glandular cells of undetermined significance (AGUS) or suspicion of carcinoma. All other patients with abnormal Papanicolaou test results were referred to abnormal cytology clinics or elected to receive follow-up care outside the study's medical system.Treatment rates for HGSIL/AGUS at 6 months, follow-up rates at 6 months for lower-grade lesions, and 1-year follow-up rates for all patients.The rate of abnormal Papanicolaou test results was 4.1%. One percent of results showed high-grade lesions. In the single-visit group, the mean visit time was 2.8 hours and the mean time for delivery and processing of the Papanicolaou tests was 66 minutes. Six months after randomization, 14 (88%) of 16 single-visit and 10 (53%) of 19 usual care patients with HGSIL/AGUS had completed treatment. Fifty percent in the single-visit program and 53% of usual care with less abnormal Papanicolaou tests completed treatment within 6 months. Overall, 36% in each group presented for a follow-up Papanicolaou test 1 year later. Women in the single-visit group with high-grade lesions (10/16; 63%) were significantly more likely to attend follow-up for Papanicolaou tests 12 months later than women with similar lesions in the usual care group (4/19; 21%).For cervical cancer screening, the single-visit program was feasible and the degree of acceptability was high in this underserved population. Single visit programs provide an opportunity to increase the rate of immediate treatment and follow-up of women with severely abnormal Papanicolaou test results. This strategy did not improve follow-up rates for women with less-abnormal results. Trial Registration http://ClinicalTrials.govIdentifier: NCT00237562.
High concentrations of soluble tumor necrosis factor receptors in ascites
Authors: Tilo Andus, Volker Gross, Axel Holstege, Margit Ott, Marlies Weber, Martina David, Harald Gallati, Wolfgang Gerok, Jürgen Schölmerich
Journal: Hepatology (1992)

Ascites and plasma concentrations of soluble tumor necrosis factor receptors p55 and p75 were measured in a prospective study in 34 patients (35 occasions of ascites) with hepatic (5 infected and 21 uninfected) and malignancy–related (9) ascites. All patients had high concentrations of both soluble tumor necrosis factor receptors in ascites and plasma; these were about 500 times higher than the corresponding tumor necrosis factor–α concentrations. Ascites levels of soluble tumor necrosis factor receptors p55 and soluble tumor necrosis factor receptors p75 were significantly elevated in patients with malignancy–related (p55: 26.0 ± 8.6 ng/ml; p75: 20.5 ± 17.4 ng/ml; mean S.D.) and infected ascites (p55: 25.1 ± 10.9 ng/ml, p75: 22.6 ± 11.0 ng/ml) compared with patients with uncomplicated hepatic ascites (p55: 10.1 ± 4.4 ng/ml; p75: 6.0 ± 2.6 ng/ml). Patients with infected or malignancy–related ascites also showed higher soluble tumor necrosis factor receptor concentrations in plasma than did patients with plain hepatic ascites. Successful antibiotic treatment of peritonitis reduced soluble tumor necrosis factor receptor p55 and p75 ascites levels in three patients from 24.2 ± 15.2 ng/ml to 10.7 ± 1.9 ng/ml and from 20.2 ± 14.4 ng/ml to 7.5 ± 1.8 ng/ml, respectively. Soluble tumor necrosis factor receptors p55 and p75 at cutoff levels of 16.5 ng/ml and 9.5 ng/ml, respectively, differentiated between infected or malignant and plain hepatic ascites with diagnostic accuracies of 94% and 89%, respectively. They did not differentiate between infected and malignant ascites. The concentrations of soluble tumor necrosis factor receptor p55 were usually higher in ascites than in plasma in all subgroups of patients. Levels of soluble tumor necrosis factor receptor p75 were also higher in ascites than in plasma in patients with malignant and infected ascites, but soluble tumor necrosis factor receptor p75 levels were usually higher in plasma than in ascites in patients with uncomplicated hepatic ascites. The concentrations of both tumor necrosis factor receptors correlated well in ascites (r = 0.83, p &lt; 0.001) and plasma (r = 0.85, p &lt; 0.001) but only weakly with tumor necrosis factor–α levels in ascites (p55: r = 0.32, p = 0.03; p75: r = 0.29, p = 0.047) and not with tumor necrosis factor–α in plasma. The high soluble tumor necrosis factor receptor concentrations found in ascites may influence the local bioavailability of tumor necrosis factor and might have an impact on the treatment of peritoneal carcinomatosis with recombinant tumor necrosis factor. Furthermore, the determination of soluble tumor necrosis factor receptors could be of value for the differential diagnosis of ascites. (Hepatology 1992;16:749-755.)
Lipidomics Profiling and Risk of Cardiovascular Disease in the Prospective Population-Based Bruneck Study
Authors: Christin Stegemann, Raimund Pechlaner, Peter Willeit, Sarah R. Langley, Massimo Mangino, Ursula Mayr, Cristina Menni, Alireza Moayyeri, Peter Santer, Gregor Rungger, Tim D. Spector, Johann Willeit, Stefan Kiechl, Manuel Mayr
Journal: Circulation (2014)

Background— The bulk of cardiovascular disease risk is not explained by traditional risk factors. Recent advances in mass spectrometry allow the identification and quantification of hundreds of lipid species. Molecular lipid profiling by mass spectrometry may improve cardiovascular risk prediction. Methods and Results— Lipids were extracted from 685 plasma samples of the prospective population-based Bruneck Study (baseline evaluation in 2000). One hundred thirty-five lipid species from 8 different lipid classes were profiled by shotgun lipidomics with the use of a triple-quadrupole mass spectrometer. Levels of individual species of cholesterol esters (CEs), lysophosphatidylcholines, phosphatidylcholines, phosphatidylethanolamines (PEs), sphingomyelins, and triacylglycerols (TAGs) were associated with cardiovascular disease over a 10-year observation period (2000–2010, 90 incident events). Among the lipid species with the strongest predictive value were TAGs and CEs with a low carbon number and double-bond content, including TAG(54:2) and CE(16:1), as well as PE(36:5) ( P =5.1×10 −7 , 2.2×10 −4 , and 2.5×10 −3 , respectively). Consideration of these 3 lipid species on top of traditional risk factors resulted in improved risk discrimination and classification for cardiovascular disease (cross-validated ΔC index, 0.0210 [95% confidence interval, 0.0010-0.0422]; integrated discrimination improvement, 0.0212 [95% confidence interval, 0.0031-0.0406]; and continuous net reclassification index, 0.398 [95% confidence interval, 0.175-0.619]). A similar shift in the plasma fatty acid composition was associated with cardiovascular disease in the UK Twin Registry (n=1453, 45 cases). Conclusions— This study applied mass spectrometry-based lipidomics profiling to population-based cohorts and identified molecular lipid signatures for cardiovascular disease. Molecular lipid species constitute promising new biomarkers that outperform the conventional biochemical measurements of lipid classes currently used in clinics.
Evaluation of Hypo-test, a Semiquantitative Audio Urine-Glucose Analyzer for Blind Diabetic Individuals
Authors: Kjeld Birch, Leif Sestoft, Michael Marshall
Journal: Diabetes Care (1982)

Hypo-test (Hypoguard Ltd., Suffolk, United Kingdom), a new semiquantitative audio urine-glucose analyzer for blind diabetic individuals, was tested for accuracy and reproducibility against a laboratory glucose method, and for ease of operation by two blind diabetic subjects. Hypo-test results were accurate for urine glucose in the range 0–0.75%, but there was a pronounced tendency for results to be too low at higher urine-glucose concentrations. The reproducibility at high urine-glucose concentrations was poor, and the meter was too sensitive to delays or decreases in the prescribed timing procedure. However, the two blind diabetic subjects found the instrument easy to operate.
Street drugs yield primate Parkinson's model
Authors: Elaine Blume
Journal: JAMA (1983)

The tragic mistake of several young drug abusers has led scientists at the National Institute of Mental Health (NIMH) to develop a unique animal model of Parkinson's disease. The animals are rhesus monkeys, and their parkinsonism is produced with 1-methyl4-phenyl-1,2,5,6-tetrahydropyridine (MPTP), a byproduct of the synthesis of a meperidine (Demerol) analogue, MPPP. The story began in November 1976, when a 23-year-old chemistry graduate student became severely rigid, mute, weak, and tremorous. He had injected himself during the course of several days with doses of a "sloppy" homemade batch of MPPP. He was admitted to the psychiatric ward of a general hospital with an initial diagnosis of catatonic schizophrenia but later was successfully treated with anti-parkinson medications and referred to NIMH for further evaluation. While receiving treatment for his parkinsonian symptoms, the student persisted in abusing drugs and finally died of an overdose in September 1978. Autopsy revealed severe loss of
The Endoscopic Multiple-diameter Bougie - Clinical Results after One Year of Application
Authors: G. Bueß, J. Thon, J. Eitenmüller, H. Schellong, E. Hildebrand, F. Hutterer
Journal: Endoscopy (1983)

A new technique for dilation of the upper gastrointestinal tract permits complete endoscopic control of the whole procedure for the first time. 113 dilations have been carried out in 37 patients within a period of 15 months. The endoscopic guidance of the multiple diameter bougie positively excludes perforation resulting from the bougie's going the wrong way. With the steerable tip of the endoscope, kinking can be overcome and stenoses down to the duodenum can be dilated.
Anglo-American contrasts in general practice.
Authors: G N Marsh, R B Wallace, J Whewell
Journal: BMJ (1976)

both countries in family practice, we thought it interesting to compare the methods of work of a group of general practitioners in north-east England with those of a group of general prac- titioners in Iowa-a state where family practice has been active continuously and where departments of family practice are flourishing.In terms of durability and tradition, the two groups could be considered to be comparable.There have been many studies of work load in general practice, especially in England, but comparatively little study of the process of consultation itself and how this varies from one doctor to another.Work load studies of general practice in the USA are comparatively rare.Mechanic2 suggests from surveys done in 1966 and 1970 that there are great differences between English and American general practitioners.Horder,3 reporting more recently on French general practitioners, again intimated there were considerable differences between them and their English equivalents.These studies, however, have not gone into the process of consultation in any depth, and it is to this aspect that we draw attention here. MethodRoughly equal numbers of general practitioners in Iowa and north- east England were asked to audit 100 patient consultations, using a pretested self-administered form.Each English and Iowan doctor had a reputation for providing good medical care, and most were taking part in undergraduate or postgraduate teaching.We thought that these doctors would represent high-standard practice in each area.Most were part of a group practice but none were in multispecialty groups.Hence they differed from Mechanic's samples,2 which were more representative of all general practitioners in England and Wales and all doctors providing primary medical care in the USA.The survey was conducted during November 1974 in each area.The doctors completed a form after 100 non-institutional consultations carried out on prespecified randomly selected times of day and days of the week.There are various methods of observing professional practitioners' activities, but since all are potentially subject to bias4 we felt justified in proceeding with this simple and very inexpensive system.The time taken to complete a form can reduce the time on 14 August
Drug-Induced Extrapyramidal Reactions
Authors: Patrick L. McGeer
Journal: JAMA (1961)

A common form of Parkinsonism today is that induced by certain ataractic drugs, particularly phenothiazines containing a piperazine moiety. Mild to severe extrapyramidal symptoms can appear and disappear within hours or days of commencing or withdrawing the drugs. With rare exceptions the syndrome is completely reversible. This study was based on the postulate that the syndrome is due to interference with the normal functioning of central catecholamines, particularly dopamine, and of central histamine. Extrapyramidal reactions caused by reserpine or 1 of 3 phenothiazines were treated with from 4 to 32 gm. per day of dihydroxyphenylalanine (dopa, the precursor of the catecholamines), with 0.4 to 0.6 gm. per day of diphenhydramine (an antihistamine), or with each in turn. Dopa was mildly beneficial in 4 out of 22 patients, whereas diphenhydramine was completely effective in each of 11
A Proprietary Medicine.
Authors: H. B. Forbes
Journal: JAMA (1900)

Ogden, Utah, Aug. 4, 1900. <h3>To the Editor:</h3> —The owners of a certain secret proprietary remedy—known as antikamnia—have recently scattered broadcast among the laity of this city—and probably of other cities —untold numbers of "faith pictures," on the backs of which appear the many indications and explicit directions for the use of the stuff, accompanied by a glowing apostrophe to "Dear Doctor, may your faith never grow less, etc.," which I enclose. It has long been a mystery to me how sensible physicians could prescribe such substances. The "faith picture" seems especially appropriate in this connection, considering the "working" propensities of both. Very respectfully,
Antioestrogens in Treatment of Breast Cancer
Authors: J. R. Hobbs, K. A. Newton, G. C. Westbury
Journal: BMJ (1974)

results, such as age, parity, and social status, failed to show any apparent bias.Furthermore, you appear to have overlooked the fact that the two studies differed in two essentials: (1) Coxon et al. investigated the use of abdominal decompression in a population of normal pregnant women and found that this had no prophylactic effect on the incidence of pre-eclampsia or the mean birth weight.We studied only those
Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia.
Authors: G R Strohmeier, W I Lencer, T W Patapoff, L F Thompson, S L Carlson, S J Moe, D K Carnes, R J Mrsny, J L Madara
Journal: Journal of Clinical Investigation (1997)

During active intestinal inflammation polymorphonuclear leukocytes (PMN) transmigrate into the lumen and release 5'-AMP (J. Clin. Invest. 1993. 91:2320-2325). 5'-AMP is converted to adenosine by the apical epithelial surface with subsequent activation of electrogenic Cl- secretion (the basis of secretory diarrhea) via apical A2b adenosine receptors (J. Biol. Chem. 1995. 270:2387-2394). Using a polarized human intestinal epithelial monolayer (T84), we now characterize the basis of the observed conversion of 5'-AMP to adenosine required for this paracrine signaling pathway. An inhibitor of the ecto-5'-nucleotidase CD73, alpha, beta-methylene ADP (AOPCP), inhibited epithelial Cl- secretory responses to 5'-AMP, but not to authentic adenosine. Confocal immunofluorescent microscopy revealed CD73 to be surface expressed on both model and natural human intestinal epithelia. Expression was about sixfold greater on the apical cell surface as assessed biochemically by selective cell surface biotinylation, and morphologically by immunofluorescence. Treatment with phosphotidylinositol specific-phospholipase C (PI-PLC) released 95% of apical CD73, indicating that the intestinal CD73 possesses a glycosylphosphatidylinositol (GPI) anchor. Neither adenosine nor 5'-AMP stimulation induced intact T84 cells to shed surface CD73. The bulk of apical CD73 ( approximately 60%) was released from the cell surface by treatment with 1% Triton X-100 (TX-100) at 4 degrees C, but such release was not affected by pretreatment with ligand or by prior, antibody-mediated cross-linking of CD73. Subsequent analyses showed that the subpool of CD73 released by TX-100 at 4 degrees C was not truly solubilized, but rather represented TX-100-induced release of CD73-containing membrane fragments. These membrane fragments displayed light density on sucrose gradients characteristic of detergent insoluble glycosphingolipid-rich membrane domains (DIGs)/ caveolae, were solubilized by n-octyl glucoside (NOG, 1%) at 4 degrees C, and contained caveolin. These data indicate that human intestinal epithelia express CD73, which is apically polarized and targeted to microdomains with DIGs/caveolae characteristics. CD73 likely participates in translating paracrine, PMN-derived 5'-AMP signals to the authentic effector adenosine. These studies define CD73 as central to PMN-mediated intestinal Cl- secretion, the major directacting mechanism by which PMN induce intestinal epithelial Cl- secretion.
Christmas on the AIDS Ward
Authors: David L. Schiedermayer
Journal: Annals of Internal Medicine (1991)

Ad Libitum15 December 1991Christmas on the AIDS WardDavid L. Schiedermayer, MDDavid L. Schiedermayer, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-12-982 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen AIDS patients try to talkand are near deaththe former Surgeon General saidthey are like kittens.They open their mouths to crybut no sound comes out.The virus spreadseven on holy days.It replicates even during feasts.It robs us of strengtheven on most high and holy days.But on the AIDS wardduring Christmas there isstrength and reasonenough to weep.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, WI 53226 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1991Volume 115, Issue 12Page: 982-982KeywordsAIDSMouthSurgeons ePublished: 1 December 2008 Issue Published: 15 December 1991 PDF downloadLoading ...
Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation
Authors: Klaas P J M van Gisbergen, Natasja A M Kragten, Kirsten M L Hertoghs, Felix M Wensveen, Stipan Jonjic, Jörg Hamann, Martijn A Nolte, Rene A W van Lier
Journal: Nature Immunology (2012)
VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice
Authors: Alexander S. Savchenko, Julian I. Borissoff, Kimberly Martinod, Simon F. De Meyer, Maureen Gallant, Luise Erpenbeck, Alexander Brill, Yanming Wang, Denisa D. Wagner
Journal: Blood (2013)
Adolescent Forensic Psychiatry
Authors: Girish Vaidya
Journal: BMJ (2005)

W hy would you read a book on adolescent forensic psychiatry? Well, there are a number of reasons, many of which have been well covered by the editors of this book. If you are a child and adolescent psychiatrist (like me), you would find such a book useful in understanding and managing risk posed by adolescents with delinquent behaviours. You would benefit from a framework for assessment—handily provided …
Points from Letters: Crisis in Venereology
Authors: D. Hill
Journal: BMJ (1970)

The patient, a widow aged 63, developed a marked bilateral conjunctivitis in July 1970.When questioned, she stated that she had noticed a stinging sensation of the eyes when- ever she tipped a new brand of washing powder into water.This powder, which she had used for a few weeks only, proved to be a well known enzyme detergent.On giving up the use of the preparation the conjunctival signs disappeared and have not returned.Presumably the act of tipping out the washing powder can give rise to a sufficient concentration of enzyme dust to affect the conjunctiva of a sensitive person.When dealing with an unexplained case of allergic conjunctivitis, therefore, it seems worth asking whether the patient has been using a new brand of washing powder.-Iam, etc.,
The impact of differential binding of wild-type RARα, PML-, PLZF- and NPM-RARα fusion proteins towards transcriptional co-activator, RIP-140, on retinoic acid responses in acute promyelocytic leukemia
Authors: CW So, S Dong, CKC So, GX Cheng, QH Huang, SJ Chen, LC Chan
Journal: Leukemia (2000)
Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis
Authors: Britta George, Qingfeng Fan, Christopher P. Dlugos, Abdulsalam A. Soofi, Jidong Zhang, Rakesh Verma, Tae-Ju Park, Hetty Wong, Tom Curran, Deepak Nihalani, Lawrence B. Holzman
Journal: Kidney International (2014)
Reduction of Serum Cholesterol and Triglyceride Levels by the Combined Administration of Neomycin and Clofibrate
Authors: PAUL SAMUEL, CHARLES M. HOLTZMAN, EDWARD MEILMAN, IGNACY SEKOWSKI
Journal: Circulation (1970)

The combined oral administration of neomycin (2 g daily) and clofibrate (2 g daily) reduced significantly serum cholesterol levels in 15 of 16 patients. Most of these patients had type II hypercholesterolemia and clinical evidence of arteriosclerosis. The combined regimen of the two drugs was more effective in reducing cholesterol levels in about one third of the patients than administration of either one of these drugs alone. The average decrease of serum cholesterol in these patients while on the combined regimen was 38% from the control values. Control serum triglyceride levels were normal in most patients, thus the effect of the drugs on triglycerides was moderate. No noteworthy side effects were encountered. It is felt that a trial of treatment by the combined administration of neomycin and clofibrate is justified in patients with type II hypercholesterolemia and arterioscleroisis who are resistant to other forms of treatment or to treatment by a single drug.