tbuckley/cabot-search huggingface dataset:
Dialysis for Psoriasis
Authors: SIMA HALEVY
Journal: Annals of Internal Medicine (1980)

Letters1 February 1980Dialysis for PsoriasisSIMA HALEVY, M.D., JONATHAN HALEVY, M.D., JOSEPH B. ROSENFELD, M.D., ELEASAR FEUERMAN, M.D.SIMA HALEVY, M.D.Search for more papers by this author, JONATHAN HALEVY, M.D.Search for more papers by this author, JOSEPH B. ROSENFELD, M.D.Search for more papers by this author, ELEASAR FEUERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-2-263_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the article in the August 1979 issue by Nissenson and associates (1) reporting the results of a controlled trial of hemodialysis in the treatment of psoriasis.We have two comments to make on the selection of patients by the author and on the method of dialysis:1. Four of the seven patients chosen by the authors for the trial had "generalized psoriatic exfoliative dermatitis," and the other three had plaque-type psoriasis. The former is considered to be a relatively uncommon complicated type of psoriasis with acute inflammatory changes (psoriatic erythroderma) that have already...References1. NISSENSONRAPAPORTGORDONNARINS AMAR. Hemodialysis in the treatment of psoriasis: a controlled trial. Ann Intern Med. 1979;91:218-20. LinkGoogle Scholar2. TWARDOWSKINOLPHRUBINANDERSON ZKJP. Peritoneal dialysis for psoriasis: an uncontrolled study. Ann Intern Med. 1978;88:349-51. LinkGoogle Scholar3. BUSELMEIER T. Psoriasis and hemodialysis. Ann Intern Med. 1979;90:722. Letter. LinkGoogle Scholar4. HALEVYHALEVYFEUERMANROSENFELD JSEJ. Dialysis for psoriasis. Br Med J 1979;1:1490. Letter. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Beilinson Medical Center Petach Tikva Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySystemic aspects of psoriasisDialysis and PsoriasisALLEN R. NISSENSON, M.D., MARVIN J. RAPAPORT, M.D., ROBERT G. NARINS, M.D. 1 February 1980Volume 92, Issue 2_Part_1Page: 263-263KeywordsErythemaMedical dialysisPsoriasis Issue Published: 1 February 1980 PDF DownloadLoading ...
The effect of maternal and child health and family planning services on mortality: is prevention enough?
Authors: V Fauveau, B Wojtyniak, J Chakraborty, A M Sarder, A Briend
Journal: BMJ (1990)

To examine the impact on mortality of a child survival strategy, mostly based on preventive interventions.Cross sectional comparison of cause specific mortality in two communities differing in the type, coverage, and quality of maternal and child health and family planning services. In the intervention area the services were mainly preventive, community based, and home delivered.Neonates, infants, children, and mothers in two contiguous areas of rural Bangladesh.In the intervention area community health workers provided advice on contraception and on feeding and weaning babies; distributed oral rehydration solution, vitamin A tablets for children under 5, and ferrous fumarate and folic acid during pregnancy; immunised children; trained birth attendants in safe delivery and when to refer; treated minor ailments; and referred seriously ill people and malnourished children to a central clinic.Overall and age and cause specific death rates, obtained by a multiple step "verbal autopsy" process.During the two years covered by the study overall mortality was 17% lower among neonates, 9% lower among infants aged 1-5 months, 30% lower among children aged 6-35 months, and 19% lower among women living in the study area than in those living in the control area. These differences were mainly due to fewer deaths from neonatal tetanus, measles, persistent diarrhoea with severe malnutrition among children, and fewer abortions among women.The programme was effective in preventing some deaths. In addition to preventive components such as tetanus and measles immunisation, health and nutrition education, and family planning, curative services are needed to reduce mortality further.
HCV and HBV infection in hemodialysis (HD) patients: risk factors for liver disease (LD) after renal transplantation (RTx)
Authors: V. Barbieri, F. Marchini, A. Floreani, P. Rigotti, P. Pontisso, A. Cecchetto, S. Fagiuoli, R. Naccarato, P. Burra
Journal: Journal of Hepatology (1998)
Hypertension 1973: Treatment—Why and How
Authors: EDWARD D. FROHLICH
Journal: Annals of Internal Medicine (1973)

Controversy on the merits of long-term antihypertensive therapy no longer exists. Recent studies have dramatically shown that arterial pressure should be reduced in all patients whose diastolic pressure exceeds 105 mm Hg. Persistent control of pressure will significantly reduce cardiovascular morbidity and mortality resulting from the hypertensive diseases. The value of pressure reduction in individuals having diastolic pressures between 90 and 105 mm Hg, or systolic hypertension, and the effect of early treatment of hypertension in retarding development of atherosclerosis remain to be shown. Still subject to clinical judgment are more sophisticated questions about the extent of clinical diagnostic evaluation and the proper course of therapy: should a standard therapeutic regimen or specific individualized therapy tailored to the clinically identified pressor mechanisms be pursued? Hypertension, afflicting over 20 million American adults, is a major public health problem that demands innovative measures and the establishment of effective medical and social programs of preventive cardiology.
Guidelines to aid ethical committees considering research in children.
Authors: J Corkery
Journal: BMJ (1980)

What the fetus feels SIR,-I welcomed Dr H B Valman's excellent summary of early fetal awareness (26 January, p 233).In addition to simple sensory modalities, I am sure that the fetus responds to admixtures of complex sensations and of those hormones that derive from mother-for example, in singing, dancing, and vomiting.When a mother undergoes ultrasound scann- ing of the fetus, this seems a great opportunity for her to meet her child socially and in this way, one hopes, to view him as a companion aboard rather than as a parasite responsible for the symptoms of pregnancy.Doctors and technicians scanning mothers have a great opportunity to enable mothers to form an early affectionate bond to their child by demonstrating the child to the mother.This should help mothers to behave concernedly towards the fetus throughout pregnancy and may be expected to increase the bond on childbirth.
Letter from Bombay: Yearning for baby boys
Authors: S. K Pandya
Journal: BMJ (1988)

Most Indian couples yearn for sons-to help on the farm, to support them in old age, to perform their last rites.At times this yearning leads to irrational acts.The availability of amniocentesis for the determination of fetal abnormality led to an unexpected development.Anxious parents to be demanded the test primarily to know whether the fetus was male.Between 1978 and 1983 78 000 female fetuses were aborted throughout the country.In one study of 1000 abortions 97% of the fetuses were female (India Today, 31 January 1988).The legally permitted use of abortion as a means of restricting the population was perverted to prevent the birth of girls.A large number of the 260 or so clinics in Bombay abetted this practice, catering not only to those living in this city but also to those in far off towns such as Jalgaon, Amravati, and Dhule.Amniotic fluid samples were transported to Bombay whence reports were sent back in 24 hours.On 31 December 1987, in response to widespread agitation, the government of Maharashtra in Bombay decided to introduce legislation to ban prenatal sex determination tests.If the proposed act becomes law amniocentesis will be permitted only at recognised medical centres and for the purpose of detecting genetic disorders.It remains to be seen how effectively such practices will be regulated.On 30 January 1988, in a teaching hospital in New Delhi, 23 year old Rajbala was outraged at being handed a baby girl a couple of days after she had given birth to a boy.When she refused to accept the unsatisfactory explanations offered by officials in the hospital a major controversy resulted.The crime branch later recovered her son from the neighbouring state of Uttar Pradash from a woman who had delivered a girl at the same hospital in Delhi and had swapped babies.
Correlation of the Oxygen Saturation of the Blood and Changes in the Electrocardiogram, Blood Pressure, and Heart Rate During the Anoxemia Test
Authors: JAMES A. L. MATHERS, ROBERT L. LEVY
Journal: Circulation (1950)

During the performance of a series of anoxemia tests the oxygen saturation of the blood has been determined by means of the Millikan oximeter. The levels of hypoxemia induced have been correlated with various other factors. The results are considered with particular reference to a possible critical range, within which changes in the circulation occur.
Preventable Deaths: Who, How Often, and Why?
Authors: Robert W. Dubois
Journal: Annals of Internal Medicine (1988)

If the quality of care provided by a hospital affects its death rate, then some deaths must be preventable. We have developed a new method to investigate this issue and have reviewed 182 deaths from 12 hospitals (6 high outliers and 6 low outliers for death rate) for three conditions (cerebrovascular accident, pneumonia, or myocardial infarction). The investigators prepared a dictated summary of each patient's hospital course. Then, at least three physicians reviewed each summary and independently judged whether the death could have been prevented. Using a majority rules criterion (at least two of three physicians agreed), we found that 27% of the deaths might have been prevented. Using a unanimity criterion (all three physicians independently agreed), we found a 14% rate of probably preventable deaths. Patients whose deaths were probably preventable were younger (74.7 compared with 78.6 years, P < 0.05), less often demented (12% compared with 26%, P < 0.05), and less severely ill (mean Acute Physiology and Chronic Health Evaluation score, 15.6 compared with 21.2; P < 0.001) than patients whose deaths were nonpreventable. The physicians also listed causes for each probably preventable death; nine reasons encompassed almost all of them. For myocardial infarction, preventable deaths reflected errors in management. For cerebrovascular accident, however, deaths primarily reflected errors in diagnosis. The severity of illness can help a hospital retrospectively identify probably preventable deaths. In the group of patients who died, 42% of those with a low severity of illness had probably preventable deaths as compared to 11% admitted with a high severity of illness. We found that a significant number of hospital deaths might have been prevented. Our findings were based on a new method that needs further testing to substantiate its validity. These findings also need replication before they can be generalized to other hospitals.
Assessment of female sex as a risk factor in atrial fibrillation in Sweden: nationwide retrospective cohort study
Authors: L. Friberg, L. Benson, M. Rosenqvist, G. Y. H. Lip
Journal: BMJ (2012)

<b>Objective</b> To determine whether women with atrial fibrillation have a higher risk of stroke than men. <b>Design</b> Nationwide retrospective cohort study. <b>Setting</b> Patients with a diagnosis of atrial fibrillation in the Swedish hospital discharge register between 1 July 2005 and 31 December 2008. Information about drug treatment taken from the Swedish drug register. <b>Participants</b> 100 802 patients with atrial fibrillation at any Swedish hospital or hospital affiliated outpatient clinic with a total follow-up of 139 504 years at risk (median 1.2 years). We excluded patients with warfarin at baseline, mitral stenosis, previous valvular surgery, or who died within 14 days from baseline. <b>Main outcome measure</b> Incidence of ischaemic stroke. <b>Results</b> Ischaemic strokes were more common in women than in men (6.2% <i>v</i> 4.2% per year, P&lt;0.0001). The univariable hazard ratio for women compared with men was 1.47 (95% confidence 1.40 to 1.54), indicating a 47% higher incidence of ischaemic stroke in women than in men. Stratification according to the CHADS<sub>2</sub> scheme showed increased stroke rates for women in all strata. After multivariable adjustment for 35 cofactors for stroke, an increased risk of stroke in women remained (1.18, 1.12 to 1.24). Among patients with “lone atrial fibrillation” (age &lt;65 years and no vascular disease), the annual stroke rate tended to be higher in women than in men, although this difference was not significant (0.7% <i>v</i> 0.5%, P=0.09). When low risk patients with CHADS<sub>2</sub> scores of 0-1 were stratified according to their CHA<sub>2</sub>DS<sub>2</sub>-VASc scores, women did not have higher stroke incidence than men at CHA<sub>2</sub>DS<sub>2</sub>-VASc scores of 2 or less. <b>Conclusion</b> Women with atrial fibrillation have a moderately increased risk of stroke compared with men, and thus, female sex should be considered when making decisions about anticoagulation treatment. However, women younger than 65 years and without other risk factors have a low risk for stroke, and do not need anticoagulant treatment.
Angiopoietin-2 TIEs Up Macrophages in Tumor Angiogenesis
Authors: Michele De Palma, Luigi Naldini
Journal: Clinical Cancer Research (2011)

Angiopoietin-2 (ANG2), a ligand of the TIE2 receptor, modulates endothelial cell biology and destabilizes blood vessels to facilitate angiogenesis. Recent reports have shown that ANG2 inhibition, for example, by monoclonal antibodies, peptibodies, or CovX-Bodies, may achieve substantial antiangiogenic and antitumor responses in a variety of mouse tumor models, including spontaneous MMTV-PyMT mammary and RIP1-Tag2 pancreatic islet adenocarcinomas. There is also evidence that targeting the ANG2/TIE2 signaling pathway may inhibit the functions of TIE2-expressing macrophages (TEM), a tumor-associated macrophage subset endowed with proangiogenic activity in mouse tumor models. The clinical opportunities afforded by simultaneously targeting the effects of ANG2 on tumor angiogenesis and the proangiogenic activity of TEMs are discussed.
Germany proposes radical plans to tackle financial crisis in health care
Authors: Annette Tuffs
Journal: BMJ (2006)

The German coalition government—and in particular the chancellor, Angela Merkel—has been heavily criticised for plans to reform the country's underfunded health system by raising the fees paid by members of state health insurance schemes.

Under the proposal healthcare insurance fees paid by employees and their employers will rise by around 0.5% by 2007. In addition, for the first time in the national health system's 150 year history, tax revenues will be used to help finance it. The government will spend €1.5bn (£1bn; $1.9bn) in 2007 and €3bn a year from 2008 onwards, mainly to help fund children's health insurance.

The …
"TREATMENT OF MIGRAINE WITH PEPTONE"
Authors: Joseph L. Miller
Journal: JAMA (1923)

<h3>To the Editor:</h3> —Hay-fever and asthma are both hereditary, just as migraine. They are now definitely recognized as sensitization diseases, and are relieved by desensitizing measures. The fact that the migraine patient following a severe infection, or frequently during pregnancy, is entirely free from attacks shows that, whatever may be the nature of the trouble, there are certain conditions which develop that give the patient temporary relief. In this respect there is a close analogy between migraine and asthma. The only attempt of the treatment is to desensitize the individual exactly as we do in asthma or hay-fever, and there is no more reason to criticize the treatment of migraine by this means than there would be to criticize the treatment of asthma or hay-fever.
Pain management of pancreatic cancer
Authors: Åke Andrén-Sandberg, Asgaut Viste, Arild Horn, Dag Hoem, Hjörtur Gislason
Journal: Annals of Oncology (1999)

Quality of life is receiving increasing attention as a criterion for the assessment of treatment, not least for surgery, in pancreatic cancer.In exocrine pancreatic cancer there are three main symptoms that must be dealt with: pain, loss of weight and jaundice.All of them seriously impair quality of life, but most often pain is the most feared by the patients.Despite this, the intensity and the quality of the pain is all too often only scantly described.In 85 consecutive patients with newly diagnosed pancreatic cancer we have prospectively registered the quality and quantity of their pain and correlated it to tumor and patient characteristics.It was found that about one fourth of the patients were totally pain free and half of all suffered a pain decribed by two or less on a Visual Analogue Scale.Only one in ten had severe pain.Although more and more patients were treated with morphine, it was still about one third of all patients that had no or only little pain in the last part of their life.Pain had a strong correlation to survival.This may be due to secondary effects like depressing the mood of the patient and reducing the food intake, but is probably more often a reflection of that generalized cancer induces more pain.Analgesic drugs are the cornerstone of the pharmacologic management of pain due to pancreatic cancer.A significant part of the patients do well with only paracetamol and nonsteroidal antiinflammatory agents.Combining these agents with narcotic analgesics can enhance pain control while lessening the dose of narcotics.A wide range of narcotics are available as well as different modes for delivery: regular pills, slow release forms, injections, subcutaneous injections, epidurals etc.Each patient's pain management should be individualized, based on the intensity of pain, the type of pain and the side effects.It is essential not only to describe the medication, but also to follow-up the development of the pain and the patient's total experience of the situation.As an alternative to narcotics, plexus celiac blocks have been used with somewhat different result; in the hands of the experts the percutaneous approach is usually sufficient, but in the hands of other also poor results are reported.During the last years thoracoscopic splanchnicectomy has been tried as a complement giving long-standing pain relief with little or no side effects in the majority of patients.With this approach the sympathic fibers lead by the symphathetic chain and further by the nervus splanchnicus major, minor and minoris are divided.The denervation is easily done and can be performed bilaterly in one seance.This method will probably be used more often as the technique is now well described.
Control of Hypertension in Diabetes
Authors: Michael L. Tuck
Journal: Diabetes Care (2003)

In this issue of Diabetes Care , Berlowitz et al. (1) report that diabetic subjects with hypertension are receiving less intensive antihypertensive therapy than patients without diabetes. This report comes from a group of investigators well known for their interest and publications in the area of proper blood pressure control (2). Using a threshold for hypertension control of ≤140/90 mmHg, they found that 73% of diabetic hypertensive subjects did not reach this target blood pressure. Using validated study methods, the authors determined that one reason for this poor control is that clinicians are not appropriately increasing antihypertensive medications, despite knowing that the levels of blood pressure are still high and above published target goals. Focused concern with glycemic control in diabetes has always been given as one reason for ignoring good overall medical control in the diabetic patient. However, Berlowitz et al. (1) show that this is not the case for why clinicians do not increase antihypertensive medications in a given visit to reach target blood pressure.

There is also the question of why this therapeutic gap in blood pressure control in diabetic compared with nondiabetic individuals should exist, given the numerous studies showing that tight blood pressure control in diabetic subjects markedly reduces the risk for cardiovascular disease and stroke (3–6). Also, there are numerous recently published guidelines, including those …
THE COMBINATION OF COLLOIDAL LEAD SELENIDE (D4S) AND RADIUM IN THE TREATMENT OF CANCER
Authors: A. T. Todd, H. M. Aldwinckle
Journal: BMJ (1929)

I MZDICJLL JOURNAL~~~~~~~ũ reter is not necessary when growths originate at a dis- tance, b-ut, as is well known, the areas above and external to its orifice are the sites (of election for these tumours.
Low Back Pain Handbook
Authors: John D. Loeser
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes15 June 1999Low Back Pain HandbookJohn D. Loeser, MDJohn D. Loeser, MDUniversity of Washington, Seattle, Washington. (Loeser)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-12-199906150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail D'Orazio BD; ed. 316 pages. Boston: Butterworth-Heinemann; 1999. $40.00. ISBN 0750696184. Order phone 800-366-2665.Field of medicine: Physical therapy.Format: Softcover book.Audience: Physical therapy students, recent trainees entering practice, and physicians who wish to learn more about concepts and strategies in physical therapy.Purpose: To provide physical therapy students and clinicians with information on the low back in a user-friendly format.Content: Seven chapters cover anatomy, pathophysiology, evaluation, and management of patients with low back pain from a physical therapy perspective. Only physical treatment methods are discussed, but reference is made to psychosocial factors that can influence patient information ... Author, Article, and Disclosure InformationAffiliations: University of Washington, Seattle, Washington. (Loeser) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1999Volume 130, Issue 12Page: 1032KeywordsComputer softwareExerciseExercise therapyLower back painPain managementPsychology ePublished: 15 August 2000 Issue Published: 15 June 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin.
Authors: L M Bradley, S R Watson, S L Swain
Journal: The Journal of Experimental Medicine (1994)

Binding of L-selectin expressed on lymphocytes to carbohydrate ligand(s) on lymph node high endothelial venules is thought to initiate lymphocyte extravasation from blood to lymph during recirculation and localization to sites of antigen (Ag) exposure. Previous studies have shown that treatment of lymphocytes with antibody to L-selectin (MEL-14) ablates trafficking to peripheral lymph nodes (PLN). In mice, naive but not memory CD4 cells express L-selectin. To examine the role of L-selectin in helper T cell migration, we studied the effects of in vivo administration of MEL-14 on CD4 cell responses. Systemic exposure of mice to MEL-14 depleted CD4 cells expressing a naive phenotype (CD45RBhi, CD44lo) from PLN but not from spleen. The majority of residual lymph node CD4 cells exhibited the reciprocal, memory phenotype (CD45RBlo, CD44hi). MEL-14 treatment prevented priming of naive CD4 cells for proliferation and cytokine production (IL-2 and IL-4) to keyhole limpet hemocyanin in PLN draining the site of Ag injection, but not in the spleen. The results suggest that naive cells were not depleted, but rather diverted to other sites where priming occurred. The data demonstrate that L-selectin mediates extravasation of naive CD4 cells into PLN and that its function cannot be replaced by other homing receptors.