tbuckley/cabot-search huggingface dataset:
A case of xeroderma pigmentosum complementation group F with neurological abnormalities
Authors: S. MORIWAKI, C. NISHIGORI, S. IMAMURA, T. YAGI, C. TAKAHASHI, N. FUJIMOTO, H. TAKEBE
Journal: British Journal of Dermatology (1993)

Journal Article A case of xeroderma pigmentosum complementation group F with neurological abnormalities Get access S. MORIWAKI, S. MORIWAKI Department of Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan Dr S. Moriwaki, Department of Dermatology, Faculty of Medicine, Kyoto University, Shogoin, Sakyo‐ku, Kyoto 606, Japan. Search for other works by this author on: Oxford Academic Google Scholar C. NISHIGORI, C. NISHIGORI Department of Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan Search for other works by this author on: Oxford Academic Google Scholar S. IMAMURA, S. IMAMURA Department of Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan Search for other works by this author on: Oxford Academic Google Scholar T. YAGI, T. YAGI Department of Experimental Radiology, Faculty of Medicine, Kyoto University, Kyoto, Japan Search for other works by this author on: Oxford Academic Google Scholar C. TAKAHASHI, C. TAKAHASHI Department of Dermatology, Shiga Medical Center for Adult Diseases, Shiga, Japan Search for other works by this author on: Oxford Academic Google Scholar N. FUJIMOTO, N. FUJIMOTO Department of Neurology, Shiga Medical Center for Adult Diseases, Shiga, Japan Search for other works by this author on: Oxford Academic Google Scholar H. TAKEBE H. TAKEBE Department of Experimental Radiology, Faculty of Medicine, Kyoto University, Kyoto, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 128, Issue 1, 1 January 1993, Pages 91–94, https://doi.org/10.1111/j.1365-2133.1993.tb00154.x Published: 01 January 1993 Article history Accepted: 11 August 1992 Published: 01 January 1993
Reforming the Health Care System
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1990)

In a preceding editorial1 I suggested that changing the American health care system to address the basic causes of inflation would be a much better solution to the cost crisis than rationing. Here I wish to explain what sorts of changes I have in mind.First of all, we need a better health insurance system. One of the inflationary features of the present system is the existence of multiple competing insurance plans, each with its own overhead costs of marketing and administration. Even more important, insurance is usually open-ended, in that it indemnifies hospitals and physicians for whatever services they . . .
1074-152 Will combinations of multiple agents produce more robust contrast imaging? An in vitro study and in vivo studies in dogs
Authors: Xiaokui Li, Hui Jiang, Diane Paine, Zuhua Mao, Aarti Hejmadi Bhat, Rima S Bader, Patrick von Behren, David Gustafson, Jonathan R Lindner, Alexander L Klibanov, David J Sahn
Journal: Journal of the American College of Cardiology (2004)
Ethnicity and Estimates of Pain by Physicians-Reply
Authors: Knox H. Todd, Jerome R. Hoffman
Journal: JAMA (1994)

<h3>In Reply.</h3> —Dr Howell makes a good point regarding our study, namely, that physician ethnicity or cultural background may play an important role in the physician/patient encounter. We were unable to detect an effect of physician ethnicity in either of our studies examining ethnicity and pain management, but given the numbers of nonwhite physicians in our practice setting, we have limited power to examine this issue.<sup>1</sup>We suspect that the assimilation process involved in medical training produces physicians that are more alike than not, and we encourage others to examine this question. Dr Young takes us to task for using the term "race" in a table heading and the term "racial bias" in our discussion. He also states that we categorized Hispanics as a separate racial group. That was not our intention. We examined ethnic and cultural differences, not genetics. We hope that no one else was confused on
Blade atrial septostomy: collaborative study.
Authors: S C Park, W H Neches, C E Mullins, D A Girod, P M Olley, G Falkowski, V A Garibjan, R A Mathews, F J Fricker, L B Beerman, C C Lenox, J R Zuberbuhler
Journal: Circulation (1982)

During the past 4 years, five institutions have collaborated in evaluating the efficacy of blade atrial septostomy. The procedure was performed in 52 patients, including 31 with transposition of the great arteries, 10 with mitral atresia, five with tricuspid atresia and six with miscellaneous anomalies. The patient's ages ranged from 1 day to 12 years (mean 13 months). Improvement occurred in 41 of 52 patients (79%). Four patients had an intact interatrial septum, and blade atrial septostomy was successfully performed by a transseptal technique. One patient died from a lacerated left atrial wall; other complications occurred in four patients. Blade atrial septostomy is an effective palliative procedure, even when the interatrial septum is thickened or intact.
Wet-nursing and rickets
Authors: T. D Thacher
Journal: Journal of the Royal Society of Medicine (2006)

In an article published in the JRSM, Volume 99, Ferner and McDowell adopted a literature review of doctors charged with manslaughter since 1795.From a reading of their article it is possible to determine that they arrived at the following conclusions.First, that there had been a significant increase in the prosecution of doctors for gross negligence manslaughter since 1990; second, that the majority of these doctors should not have been prosecuted; third, that the Crown Prosecution Service (CPS) has failed to abide by its own prosecution Code; and fourth, that we have charged doctors as 'an emotionally satisfying way to exact retribution . . .'We question the methodology, analysis and conclusions reached by the authors.They relied for the most part on newspaper reports, a notoriously unreliable source, for an accurate account of the allegations.In every case all the evidence is considered by experienced doctors before any prosecution is commenced.We apply the criminal law on gross negligence manslaughter as we are required to do, yet Ferner and McDowell criticise us for not using the criteria of 'mistakes, slips (or lapses) and violations', tests that are unknown to the criminal law.Ferner and McDowell have failed to understand the CPS 'realistic prospect of conviction' test and have applied a simplistic numerical test against all the cases they could identify.The test is whether in this particular case there is a realistic prospect of conviction, not whether half of all defendants are convicted.The suggestion that, by charging doctors with manslaughter, the CPS is somehow seeking some emotional satisfaction in retribution is self-evidently bizarre and entirely unsupported by any evidence.
Alcohol consumption and the risk of alcohol related cirrhosis in women.
Authors: R Norton, R Batey, T Dwyer, S MacMahon
Journal: BMJ (1987)

The risks in women of cirrhosis with a likely primary alcohol aetiology were estimated for various levels of alcohol consumption in a case-control study. Data were obtained from 41 women with a first diagnosis of cirrhosis who had no evidence of non-alcohol-related cirrhosis; three matched controls were interviewed for each case. Significant increases in the risk of cirrhosis were detected at levels of consumption between 41 and 60 g daily; above this level a dose-response relation was observed. The risk of cirrhosis did not appear to be influenced by other nutritional factors or history of liver disease or use of hepatotoxic drugs. One per cent of Australian women consume more than 40 g alcohol daily, yet more than 90% of women identified with cirrhosis consumed alcohol at this level. Preventive interventions to reduce alcohol consumption in the small group of women who consume more than 40 g daily have the potential to reduce substantially the incidence of alcohol related cirrhosis.
Bullying in schools: self reported anxiety, depression, and self esteem in secondary school children
Authors: G Salmon, A James, D M Smith
Journal: BMJ (1998)

syndrome need to be based on population data that include births and terminations of pregnancy.We acknowledge the role of South Australian midwives and neonatal nurses in providing perinatal data and of doctors in providing data on congenital abnormalities; the contribution of staff of the South Australian Births Defects Register and the Pregnancy Outcome Unit in processing and collating data on babies with Down's syndrome, births, and terminations of pregnancy; and the staff of the department of cytogenetics and molecular genetics, Women's and Children's Hospital, and of the department of cytogenetics, Queen Elizabeth Hospital, for providing cytogenetic data.Contributors: AC initiated and planned the study, reviewed the literature, performed the univariate analysis, participated in the interpretation of data, and wrote the paper.KAM performed the Poisson regression analysis and participated in the planning of the study, the interpretation of data, and writing the paper.RJK participated in the planning of the study, the validation of some case details, the retrieval and preparation of data for analysis, and editing the manuscript.EAH participated in planning the study, interpreting the data, and editing the manuscript.
Exposure of the general population to gasoline.
Authors: G G Akland
Journal: Environmental Health Perspectives (1993)

This paper summarizes the currently available information on gasoline exposure to the general population. In general, the largest contribution to the time weighted exposures results from exposures while indoors, which are influenced by the outside air, indoor sources, and attached garages. Personal activities, including refueling and commuting, contribute significantly higher exposures but last for only a small portion of the 24-hr time weighted average. The highest exposed group includes those individuals living near large service stations and those with contaminated water supplies.
NHS launches English recruitment website
Authors: M. Gould
Journal: BMJ (2003)

<h3>Objective:</h3> Efficacy and safety findings from two pivotal Phase 3 studies of lasmiditan for acute treatment of migraine are reported here. <h3>Background:</h3> Lasmiditan is a novel centrally acting serotonin (5-HT<sub>1F</sub>) agonist that lacks vasoconstrictive activity. <h3>Design/Methods:</h3> SAMURAI (NCT02439320) and SPARTAN (NCT02605174) were Phase 3, randomized, double-blind, placebo-controlled studies. Inclusion criteria included Migraine Disability Assessment Score ≥11 (moderate disability) and 3–8 migraine attacks per month. Patients were randomized to a first dose of treatment (SAMURAI, 1:1:1 ratio of lasmiditan 200/100 mg or placebo, SPARTAN, 1:1:1:1 ratio of lasmiditan 200/100/50 mg or placebo) which was taken within 4 hours of migraine onset (moderate severity or worse and not improving). For rescue or recurrence, patients took a randomly assigned second dose of the previously assigned lasmiditan dose or placebo. The primary and key secondary analyses compared the proportions of patients in the lasmiditan 200-mg group with the placebo group who were headache pain-free and who were most bothersome symptom (MBS)-free at 2 hours post-first dose, respectively. Treatment-emergent adverse events (TEAEs) were used to assess safety. Logistic regression was used for comparisons. <h3>Results:</h3> At 2 hours post-first dose, significantly greater proportions of patients (p&lt;0.001) were headache pain-free (lasmiditan 200 mg: SAMURAI 32.2%, SPARTAN 38.8%; placebo: SAMURAI 15.3%, SPARTAN 21.3%) and MBS-free (lasmiditan 200 mg: SAMURAI 40.7%, SPARTAN 48.7%; placebo: SAMURAI 29.5%, SPARTAN 33.5%) with lasmiditan 200 mg compared with placebo. For both endpoints, significance was also noted for other lasmiditan dose groups (100 mg, 50 mg) compared to placebo. The most frequently reported TEAEs with lasmiditan (≥2% and greater than placebo) after the first dose were dizziness, paresthesia, somnolence, fatigue, nausea, and lethargy, and most events were mild-to-moderate in severity. <h3>Conclusions:</h3> The primary and key secondary endpoints were met and safety outcomes were consistent across the two Phase 3 studies. <b>Study Supported by:</b> CoLucid Pharmaceuticals, Inc., a wholly owned subsidiary of Eli Lilly and Company and Eli Lilly and Company, Indianapolis, IN <b>Disclosure:</b> Dr. Wietecha has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lilly and Company. Dr. Wietecha has received compensation for serving on the Board of Directors of Eli Lilly and Company. Dr. Kuca has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with CoLucid Pharmaceuticals, Inc./Eli Lilly and Company. Dr. Asafu-Adjei has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lilly and Company. Dr. Aurora has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lilly and Company.
Progression From Precursor Disease to Multiple Myeloma—Reply
Authors: Ola Landgren
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of contractile state by maximal ventricular power divided by the square of end-diastolic volume.
Authors: D A Kass, R Beyar
Journal: Circulation (1991)

BACKGROUND Maximal ventricular power (PWRmax) reflects contractile state and has the potential to be noninvasively determined. However, its sensitivities to preload, afterload resistance, and inotropic state are incompletely defined. The present study determines these dependencies and proposes a novel power-based contractile index that is little altered by load. METHODS AND RESULTS Seven open-chest, autonomically blocked dogs were instrumented with a proximal aortic flow probe, central aortic and ventricular micromanometers, and a conductance catheter for ventricular chamber volume. Preload was transiently reduced by left atrial hemorrhage, and afterload was increased by intra-aortic balloon inflation. Inotropic state was pharmacologically altered by lidocaine, dobutamine, propranolol, or verapamil. PWRmax was highly preload sensitive, altering 1.7 +/- 0.1-fold a given percent change in end-diastolic volume (EDV). This preload dependence was reduced by dividing PWRmax by EDV but was virtually eliminated when PWRmax was divided by EDV2. This latter index also displayed little change in response to as much as 60% increases in afterload resistance. PWRmax/EDV2 varied directly with inotropic state, correlating to both the slope (Ees) of the end-systolic pressure-volume relation (PWRmax x 1,000/EDV2 = 0.31 x Ees - 0.04, r = 0.82, p less than 0.001) and the slope (A) of the dP/dtmax-EDV relation (PWRmax x 1,000/EDV2 = 0.025 x A + 0.02, r = 0.86, p less than 0.001). PWRmax values determined from the product of ventricular pressure and flow versus central aortic pressure and flow were nearly identical over a broad loading range, indicating that PWRmax may be noninvasively assessed (i.e., without requiring left ventricular chamber pressure). CONCLUSIONS PWRmax divided by EDV2 provides a measure of contractile function that is little influenced by loading conditions and has potential for noninvasive clinical use.
Medical Examiners, Coroners, and Organ Recovery in the United States
Authors: Thomas F. Hegert
Journal: JAMA (1995)

To the Editor.  —The article by Ms Shafer and colleagues 1 emphasizes the impact of the medical examiner's denial for organ recovery but says little of the nearly 90% consent rate for recovery in medical examiner cases. The article strongly suggests the use of compelling legislation to achieve a 100% consent rate from medical examiners. The authors discuss the lack of formal accountability for the consequences of cases not released by medical examiners.  Legislation requiring 100% compliance and methods of formal accountability do not govern any other agency within the organ and tissue transplantation community.  The commitment of the physicians of the National Association of Medical Examiners is clearly stated in their brochure, Policy and Guidelines on Human Organ and Tissue Procurement. These concepts were made available to the transplant community in 1988. They served to assist all medical examiners in developing standards of excellence in working with local OPOs.
Mitochondrial mismatch analysis is insensitive to the mutational process
Authors: A. Rogers, A. Fraley, M. Bamshad, W. Watkins, L. Jorde
Journal: Molecular Biology and Evolution (1996)

Mismatch distributions are histograms showing the pattern of nucleotide (or restriction) site differences between pairs of individuals in a sample. They can be used to test hypotheses about the history of population size and subdivision (if selective neutrality is assumed) or about selection (if a constant population size is assumed). Previous work has assumed that mutations never strike the same site twice, an assumption that is called the model of infinite sites. Fortunately, the results are surprisingly robust even when this assumption is violated. We show here that (1) confidence regions inferred using the infinite-sites model differ little from those inferred using a model of finite sites with uniform site-specific mutation rates, and (2) even when site-specific mutation rates follow a gamma distribution, confidence regions are little changed until the gamma shape parameter falls well below its plausible range, to roughly 0.01. In addition, we evaluate and reject the proposition that mismatch waves are produced by pooling data from several subdivisions of a structured population.
The Mortality Experience of a Population with Psychiatric Illness
Authors: HAROUTUN M. BABIGIAN, CHARLES L. ODOROFF
Journal: American Journal of Psychiatry (1969)

Previous studies of mortality among psychiatric patients have dealt only with inpatient populations. This study analyzes the mortality experience of persons having received psychiatric care as inpatients or outpatients in public and private institutions. The relative risk of death for the psychiatric care group was found to be two and one-half to three times that for the comparable general population. Variables such as diagnosis, cause of death, marital status, facility, and socioeconomic status are examined in an attempt to explain this high risk of death.
Deep vein thrombosis and anaesthetic technique in emergency hip surgery.
Authors: J Cundy, D Negus
Journal: BMJ (1981)

Eight patients were studied 3 to 16 years (mean, 10 years) after cerebral hemispherectomy. Seven had infantile hemiplegia, and one had Sturge-Weber disease. Preoperative assessment included EEG responses to intracarotid drug injections. Postoperative complications occurred in seven patients. The operation was followed by a marked reduction in seizure frequency and improvement in behavior, with little change in intellect or hemiplegia. Neuropsychological assessment performed in four patients showed that they were not aphasic, but nonverbal spatial abilities were poor. CT showed marked shift of the remaining hemisphere in five of six patients scanned.
Mysoline
Authors: William H. Timberlake, John A. Abbott, Robert S. Schwab
Journal: New England Journal of Medicine (1955)

THE adequate control of epileptic seizures continues to be a challenge to medicine. Mysoline, an agent effective against several types of seizures, recently became available.1 More physicians should be aware not only of its range of effectiveness but also of its proper administration and its side effects. If it is not started in small doses so that the body develops tolerance to its side effects, it may have to be prematurely discarded, and the patient deprived of its help.Mysoline (5-phenyl, 5-ethyl-hexahydropyrimidine-4:6 dione), also called "Primidone," though chemically different, has a structure that resembles that of the barbiturates,2 as demonstrated . . .
Hospital Outbreak of Cross-infection Due to Staphylococcus Pyogenes Phage Type 80
Authors: J. R. B. Williams, E. C. S. Talbot, E. Maughan
Journal: BMJ (1959)

The recent increase in cross-infection in hospitals due to antibiotic-resistant strains of Staphylococcus pyogenes is a matter of general concern. In Hitchin we have recently had experience of such an outbreak due mainly to a strain belonging to phage type 80. This strain has been responsible for two outbreaks in Australia (Rountree and Freeman, 1955 ; Taft, 1955) and gave rise to an epidemic in Southampton (Duthie, 1957). Records of epidemics of virulent staphylococci affecting whole hospitals are few, and include that in Southampton, one in Montreal which has been reviewed by Starkey (1956), and an outbreak in Calgary (Colbeck, 1949). Our attempts to eliminate the infection by isolation, treatment of carriers, and hygienic measures in the wards, combined with reduction of admissions and closure of wards, have failed. The information acquired during this attempt and the factors which led to its failure seem worth publishing so that, perhaps, other workers may not have the same experience. The Hitchin Hospitals comprise the Lister Hospital (256 beds), a hutted old E.M.S. hospital, with recent additions, and the North Herts and South Beds Hospital, brick-built with 116 beds. The two hospitals work as a single functional unit except for the maternity unit of 40 beds, which has its own staff, living and eating separately. This paper describes the incidence and types of lesions due to tetracycline-resistant staphylococci from July, 1956, to July, 1958. The data for the first year were obtained from laboratory records and case notes ; from July, 1957, to July, 1958, special records were kept day by day as the cases occurred. For 11 weeks from the end of November, 1957, weekly nasal swabs from in-patients and staff were taken, this period covering the time of attempted wholesale clearance of the infective strains from the two hospitals. Records of the carrier rate of certain wards were also obtained for several months after clearing operations.
238 Radiofrequency ablation vs. surgical resection in the treatment of small hepatocellular carcinoma — A comparative study
Authors: M.S. Choi, S.N. Hong, J.H. Lee, K.C. Koh, S.W. Paik, B.C. Yoo, J.C. Rhee, D. Choi, H.K. Lim, J.W. Joh
Journal: Journal of Hepatology (2004)