Never Too Fit for Body and Mind
Authors: Mary Sano
Journal: Annals of Internal Medicine (2013)

Editorials5 February 2013Never Too Fit for Body and MindMary Sano, PhDMary Sano, PhDFrom Mount Sinai School of Medicine and James J. Peters Veterans Affairs Medical Center, New York and Bronx, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-3-201302050-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail There is a tidal wave of evidence about the benefits of physical fitness in several health areas across the life span, including benefits on cognition and prevention of dementia. The evidence comes in many forms, such as epidemiologic studies identifying associations between physical activity or fitness measures and cognitive performance, clinical studies measuring the association between fitness and biomarkers of cognition and brain function, clinical trials demonstrating improvements in cognition associated primarily with aerobic activity interventions, and basic in vitro and in vivo biological studies implicating neuromechanisms affected by aerobic activity.In this issue, the work presented by DeFina and ...References1. DeFina LF, Willis BL, Radford NB, Gao A, Leonard D, Haskell WL, et al. The association between midlife cardiorespiratory fitness levels and later-life dementia. A cohort study. Ann Intern Med. 2013;158:162-8. LinkGoogle Scholar2. Faselis C, Doumas M, Panagiotakos D, Kheirbek R, Korshak L, Manolis A, et al. Body mass index, exercise capacity, and mortality risk in male veterans with hypertension. Am J Hypertens. 2012;25:444-50. [PMID: 22237157] CrossrefMedlineGoogle Scholar3. Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol. 2011;10:819-28. [PMID: 21775213] CrossrefMedlineGoogle Scholar4. Liu R, Sui X, Laditka JN, Church TS, Colabianchi N, Hussey J, et al. Cardiorespiratory fitness as a predictor of dementia mortality in men and women. Med Sci Sports Exerc. 2012;44:253-9. [PMID: 21796048] CrossrefMedlineGoogle Scholar5. Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW, McTiernan A, et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol. 2010;67:71-9. [PMID: 20065132] CrossrefMedlineGoogle Scholar6. Hakola L, Komulainen P, Hassinen M, Savonen K, Litmanen H, Lakka TA, et al. Cardiorespiratory fitness in aging men and women: the DR's EXTRA study. Scand J Med Sci Sports. 2011;21:679-87. [PMID: 20536910] CrossrefMedlineGoogle Scholar7. Kokkinos P, Myers J, Faselis C, Doumas M, Kheirbek R, Nylen E. BMI-mortality paradox and fitness in African American and Caucasian men with type 2 diabetes. Diabetes Care. 2012;35:1021-7. [PMID: 22399701] CrossrefMedlineGoogle Scholar8. Middleton LE, Barnes DE, Lui LY, Yaffe K. Physical activity over the life course and its association with cognitive performance and impairment in old age. J Am Geriatr Soc. 2010;58:1322-6. [PMID: 20609030] CrossrefMedlineGoogle Scholar9. Tucker JM, Welk GJ, Beyler NK. Physical activity in U.S.: adults compliance with the Physical Activity Guidelines for Americans. Am J Prev Med. 2011;40:454-61. [PMID: 21406280] CrossrefMedlineGoogle Scholar10. Weiss DR, Wolfson C, Yaffe MJ, Shrier I, Puts MT. Physician counseling of older adults about physical activity: the importance of context. Am J Health Promot. 2012;27:71-4. [PMID: 23113775] CrossrefMedlineGoogle Scholar11. MetLife Foundation. What America Thinks: MetLife Foundation Alzheimer's Survey. February 2011. Accessed at www.metlife.com/assets/cao/contributions/foundation/alzheimers-2011.pdf on 13 December 2012. Google Scholar Author, Article, and Disclosure InformationAuthors: Mary Sano, PhDAffiliations: From Mount Sinai School of Medicine and James J. Peters Veterans Affairs Medical Center, New York and Bronx, New York.Grant Support: Dr. Sano is supported by the Alzheimer Disease Research Center NIA P50AG05138-20.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M12-3102.Corresponding Author: Mary Sano, PhD, James J. Peters Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468; e-mail, [email protected]. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Association Between Midlife Cardiorespiratory Fitness Levels and Later-Life Dementia Laura F. DeFina , Benjamin L. Willis , Nina B. Radford , Ang Gao , David Leonard , William L. Haskell , Myron F. Weiner , and Jarett D. Berry Metrics 5 February 2013Volume 158, Issue 3Page: 213-214KeywordsBehaviorClinical trialsCognitionCohort studiesDementiaExerciseHypertensionMortalityMotivationPhysical fitness ePublished: 5 February 2013 Issue Published: 5 February 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...