Clinical and Genetic Aspects of Coagulopathies
Authors: FRITZ KOLLER
Journal: Annals of Internal Medicine (1965)

Article1 April 1965Clinical and Genetic Aspects of CoagulopathiesWith Special Emphasis on Generalized Intravascular ClottingFRITZ KOLLERFRITZ KOLLERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-744 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBlood must fulfill two purposes that can be reconciled only with difficulty: It should remain fluid in order to assure the nutrition of the organs; and it must, in case of injuries, solidify rapidly in order to avoid a dangerous blood loss. Blood coagulation with its inhibitors and antagonists serves this double purpose. It is completed by additional mechanisms of hemostasis, that is, vascular and platelet reactions. The present report will discuss only the most extensively studied disorders of blood coagulation.CLOTTING FACTORSClinicians are often accused of having complicated excessively the simple coagulation scheme proposed by physiologists in the...References1. OERIMATTERISENSCHMIDHAUSERKOLLER JMHFF: Angeborener mangel an faktor V verbunden mit echter haemophilie A bie zwei brüdern. Modern Problems in Pediatrics I, Karger-Verlag, Basel, 1954, p. 575. Google Scholar2. GRAHAM JB: Biochemical genetics of blood coagulation. Amer. J. Hum. Genet. 8: 63, 1956. MedlineGoogle Scholar3. WRIGHT IS: The International Committee on Blood Clotting Factors—the past, present and future, in Fibrinogen and Fibrin, Transactions of the Conference of the International Committee on Blood Clotting Factors, Gleneagles, 1963. F. K. Schattauer, Stuttgart, 1964. Google Scholar4. KOLLER F: "Latente" Haemophilie und Diensttauglichkeit. Vjschr. Schweiz. Sanitaetsoffiz. 34: 183, 1957. MedlineGoogle Scholar5. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRITZ KOLLERAffiliations: Basel,From the University of Basel, Basel, Switzerland.This paper was presented as an honorary fellowship lecture before the Forty-fourth Annual Session of the American College of Physicians, April, 1963, in Denver, Colo.Requests for reprints should be addressed to Prof. Dr. Fritz Koller, University of Basel, Basel, Switzerland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNucleotide sequence of the plasminogen activator gene of Yersinia pestis: relationship to ompT of Escherichia coli and gene E of Salmonella typhimuriumA propos d'une observation de Méningococcie suraiguë avec Purpura fulminans chez le sujet âgéThe Role of Heparin in the Management of Consumption CoagulopathyThe Syndrome of Asplenia, Pneumococcal Sepsis, and Disseminated Intravascular CoagulationALAN L. BISNO, M.D., JOHN C. FREEMAN, M.D.Disseminated intravascular coagulationCoumarin-induced skin necrosis in a sixteen year old girlThe Clinical Significance of Necrosis of the SkinPathogenesis of plagueChanges in the fibrinolytic enzyme system following intravascular coagulation induced by thrombin and endotoxinTherapeutic implications of disseminated intravascular coagulationHemopoietic SystemDie ?abnorme? chirurgische BlutungA Guide to Disorders of HemostasisMEHRAN GOULIAN, M.D. 1 April 1965Volume 62, Issue 4Page: 744-756KeywordsBloodBlood coagulationClinical geneticsFellowshipsHemophilia AHemophilia BHemostasisNutritionPathogenesisPlatelets ePublished: 1 December 2008 Issue Published: 1 April 1965 PDF downloadLoading ...