tbuckley/cabot-search huggingface dataset:
Identification and Predictive Value of Interleukin-6 <sup>+</sup> Interleukin-10 <sup>+</sup> and Interleukin-6 <sup>−</sup> Interleukin-10 <sup>+</sup> Cytokine Patterns in ST-Elevation Acute Myocardial Infarction
Authors: Enrico Ammirati, Carlo V. Cannistraci, Nicole A. Cristell, Viviana Vecchio, Alessio G. Palini, Per Tornvall, Anna M. Paganoni, Ewa A. Miendlarzewska, Laura M. Sangalli, Alberto Monello, John Pernow, Marie Björnstedt Bennermo, Giancarlo Marenzi, Dayi Hu, Neal G. Uren, Domenico Cianflone, Timothy Ravasi, Angelo A. Manfredi, Attilio Maseri
Journal: Circulation Research (2012)

At the onset of ST-elevation acute myocardial infarction (STEMI), patients can present with very high circulating interleukin-6 (IL-6(+)) levels or very low-IL-6(-) levels.We compared these 2 groups of patients to understand whether it is possible to define specific STEMI phenotypes associated with outcome based on the cytokine response.We compared 109 patients with STEMI in the top IL-6 level (median, 15.6 pg/mL; IL-6(+) STEMI) with 96 in the bottom IL-6 level (median, 1.7 pg/mL; IL-6(-) STEMI) and 103 matched controls extracted from the multiethnic First Acute Myocardial Infarction study. We found minimal clinical differences between IL-6(+) STEMI and IL-6(-) STEMI. We assessed the inflammatory profiles of the 2 STEMI groups and the controls by measuring 18 cytokines in blood samples. We exploited clustering analysis algorithms to infer the functional modules of interacting cytokines. IL-6(+) STEMI patients were characterized by the activation of 2 modules of interacting signals comprising IL-10, IL-8, macrophage inflammatory protein-1α, and C-reactive protein, and monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and monokine induced by interferon-γ. IL-10 was increased both in IL-6(+) STEMI and IL-6(-) STEMI patients compared with controls. IL-6(+)IL-10(+) STEMI patients had an increased risk of systolic dysfunction at discharge and an increased risk of death at 6 months in comparison with IL-6(-)IL-10(+) STEMI patients. We combined IL-10 and monokine induced by interferon-γ (derived from the 2 identified cytokine modules) with IL-6 in a formula yielding a risk index that outperformed any single cytokine in the prediction of systolic dysfunction and death.We have identified a characteristic circulating inflammatory cytokine pattern in STEMI patients, which is not related to the extent of myocardial damage. The simultaneous elevation of IL-6 and IL-10 levels distinguishes STEMI patients with worse clinical outcomes from other STEMI patients. These observations could have potential implications for risk-oriented patient stratification and immune-modulating therapies.
Muscular Subaortic Stenosis
Authors: Gary H. Manchester
Journal: New England Journal of Medicine (1963)

ACCURATE diagnosis of obstruction to the outflow tract from the left ventricle was not considered necessary until the development of extracorporeal circulation and open-heart surgery. The diagnosis of stenosis of the aortic valve was usually considered adequate. Although supravalvular and subvalvular stenosis were known these diagnoses were of academic interest, usually made in retrospect.Today, the precise cause for left-ventricle outflow obstruction must be known before the appropriate surgical procedure can be determined. Open-heart surgery revealed still another obstructive lesion of the outflow tract that may simulate aortic stenosis, mitral insufficiency or ventricular septal defect. Brock1 was the first to . . .
The Impact of Socio-Cultural Factors on Symptom Formation
Authors: Pieter A. van Keep, Jean M. Kellerhals
Journal: Psychotherapy and Psychosomatics (1974)

Biology and culture are not completely independent spheres, but overlap partially. This is demonstrated with some data from a study involving interviews with 448 Swiss women of 41–60 years of age. It is shown that the impact of ageing and of the menopause as measured from two indices – climacteric complaints and subjective adaptation to daily life – is more severe in women of the lower social classes than in women of the higher social classes. Women who still have children at home are to some extent protected from the adverse effects of the crisis, the menopause. A plea is made for a more positive approach by the medical and related professions toward the menopause and ageing, as well as for a more realistically accommodating attitude on the part of legislative bodies.
The critical role of agrin in the hematopoietic stem cell niche
Authors: Cristina Mazzon, Achille Anselmo, Javier Cibella, Cristiana Soldani, Annarita Destro, Natalie Kim, Massimo Roncalli, Steven J. Burden, Michael L. Dustin, Adelaida Sarukhan, Antonella Viola
Journal: Blood (2011)
Identification and characterization of rod-derived cone viability factor
Authors: Thierry Léveillard, Saddek Mohand-Saïd, Olivier Lorentz, David Hicks, Anne-Claire Fintz, Emmanuelle Clérin, Manuel Simonutti, Valérie Forster, Nükhet Cavusoglu, Frédéric Chalmel, Pascal Dollé, Olivier Poch, George Lambrou, José-Alain Sahel
Journal: Nature Genetics (2004)
Renal Transplant Nuclear Tomography Using Tc-99m MAG3
Authors: NANCY J. NEUBAUER, LEAH J. JOHNSON, MICHAEL J. LEMMERS, BRENDA B. HAAS, GERALD L. JARBOE, JEFFREY S. STEVENS
Journal: Clinical Nuclear Medicine (1996)

In this study, the authors performed SPECT imaging on 12 renal transplant patients immediately after a routine planar study demonstrated tubular stasis. The stasis allowed the authors to obtain good quality tomograms on all of them. In five patients, the findings on the planar and SPECT studies were identical. In five patients, there was decreased upper pole activity on planar images and SPECT imaging differentiated between attenuation (4 patients) and cortical thinning (1 patient). In the remaining two patients, the SPECT images showed unanticipated information. It is not yet clear if this new information is of clinical value. It was concluded that diagnostic quality nuclear tomograms in renal transplant patients with tubular stasis can be easily and consistently obtained.
B-Complex Vitamins in Liver Disease.
Authors: Carroll M. Leevy
Journal: Annals of Internal Medicine (1964)

s1 April 1964B-Complex Vitamins in Liver Disease.Carroll M. Leevy, M.D., F.A.C.P., Herman Baker, Ph.D., Willem tenHove, M.D., Oscar Frank, Ph.D., Gilbert R. Cherrick, M.D.Carroll M. Leevy, M.D., F.A.C.P.Search for more papers by this author, Herman Baker, Ph.D.Search for more papers by this author, Willem tenHove, M.D.Search for more papers by this author, Oscar Frank, Ph.D.Search for more papers by this author, Gilbert R. Cherrick, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-721_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSupplemental B-complex vitamins are widely given in liver disease, however, the usefulness of such therapy in improving hepatic status is not known. The present paper records observations on the influence of liver injury on B-complex vitamin utilization, and effects of B-complex deficiency on perpetuation of hepatic disease. Studies were conducted in experimental animals and man to determine (a) the influence of necrosis, teatosis, and cirrhosis of the liver on hepatic uptake storage, and utilization of B-complex vitamins, and (b) the effect of B-complex vitamin deficiency on hepatic subcellular structure and regenerative potential. Circulating and tissue vitamin levels were measured microbiologically;... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Carroll M. Leevy, M.D., F.A.C.P.; Herman Baker, Ph.D.; Willem tenHove, M.D.; Oscar Frank, Ph.D.; Gilbert R. Cherrick, M.D.Affiliations: Jersey City, New Jersey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIncidence and Significance of Hypovitaminemia in a Randomly Selected Municipal Hospital Population 1 April 1964Volume 60, Issue 4Page: 721-721KeywordsCirrhosisLiverLiver diseasesNecrosisVitamins ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
ONYCHIA DUE TO CHRONIC HYPOVITAMINOSIS
Authors: Cleveland White
Journal: JAMA (1934)

Clinical pictures of unmistakable signs and symptoms due to hypovitaminosis or avitaminosis are well known. In a recent editorial<sup>1</sup>ofThe Journalare emphasized the remarks of McLester<sup>2</sup>that chronic vitamin deficiency may produce vague borderline or subclinical disorders. While many syndromes are being attributed to lack of vitamins at the present time, seven cases of definite nail deformities have been observed in the past two years which are believed to have been due to chronic hypovitaminosis, especially B<sub>2</sub>and D. <h3>CLINICAL MANIFESTATIONS</h3> The earliest manifestations are irregular, longitudinal ridging with short transverse, semipunctate depressions. This was first observed in a woman, aged 38, who had restricted her diet too severely in controlling the symptoms of another disease. The six other patients were all women who had dieted for several years because of a marked tendency to become obese. Ages ranged from 35 to 50. All had
Susceptibility of <i>Malassezia furfur</i> subgroups to terbinafine
Authors: J.P. LEEMING, J.E. SANSOM, J.L. BURTON
Journal: British Journal of Dermatology (1997)

Malassezia furfur, the fungus causing pityriasis versicolor, has been reported to be sensitive to terbinafine in vitro but although topical therapy is effective in the treatment of pityriasis versicolor, oral therapy is not. This phenomenon was investigated by determining the susceptibility to terbinafine of different M. furfur subgroups in vivo (during topical or oral application) and in vitro. All M. furfur subgroups were suppressed (approximately 10-fold) by topical terbinafine. Oral treatment resulted in no significant suppression of cutaneous M. furfur populations with the exception of a single subgroup (A), which was reduced to undetectable levels on the skin of eight of 10 patients receiving oral terbinafine. Isolates of subgroup A were also markedly more susceptible to terbinafine in laboratory tests. The importance of the recognition of distinct subgroups within the cutaneous lipophilic yeasts when evaluating their antifungal susceptibility and their role in disease is discussed.
Lung Epithelial CCAAT/Enhancer-binding Protein-β Is Necessary for the Integrity of Inflammatory Responses to Cigarette Smoke
Authors: Lukas Didon, Jenny L. Barton, Abraham B. Roos, Gordon J. Gaschler, Carla M. T. Bauer, Tove Berg, Martin R. Stämpfli, Magnus Nord
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Cigarette smoke is the major cause of chronic obstructive pulmonary disease and lung cancer. The mechanisms by which smoking induces pulmonary dysfunction are complex, involving stress from toxic components and inflammatory responses. Although CCCAAT/enhancer-binding protein (C/EBP)-β is known as a key intracellular regulator of inflammatory signaling, its role in pulmonary inflammation has not been established.To characterize the role of C/EBPβ in the airway epithelial response to cigarette smoke.mRNA expression in the airway epithelium of current, former, and never-smokers, and in in vitro cigarette smoke extract-treated primary human airway epithelial cells, was analyzed by microarray and quantitative real-time polymerase chain reaction, respectively. Mice with lung epithelial-specific inactivation of C/EBPβ were generated and exposed to cigarette smoke for 4 or 11 days. Lung histology, bronchoalveolar lavage cell differentials, and expression of inflammatory and innate immune mediators in the lungs were assessed.C/EBPβ was significantly down-regulated in the airway epithelium of both current and former smokers compared with never-smokers, and in cigarette smoke-treated primary human airway epithelial cells in vitro. Cigarette smoke-exposed mice with a lung epithelial-specific inactivation of C/EBPβ displayed blunted respiratory neutrophil influx and compromised induction of neutrophil chemoattractants growth-regulated oncogene-α, macrophage inflammatory protein-1γ, granulocyte colony-stimulating factor, and serum amyloid A 3 and proinflammatory cytokines tumor necrosis factor-α and interleukin-1β, compared with smoke-exposed controls. Inhibition of C/EBPβ in human airway cells in vitro caused a similarly compromised response to smoke.Our data suggest a previously unknown role for C/EBPβ and the airway epithelium in mediating inflammatory and innate immune responses to cigarette smoke.
The Bounty Hunters
Authors: G. G. Liddle
Journal: JAMA (1976)

<h3>To the Editor.—</h3> During the winning of the West, bounties were frequently offered for the heads of villains, dead or alive. As suggested in Bierce's<i>Devil's Dictionary</i>, bounties were prompted or supported, or even paid, by insurance companies, for which Bierce entertained woeful disrespect. This led to my great uncle Gregory's Third Law of Liddle, "Whither there shall be a bounty proffered, there shall be a hunter thereof, or two." Honoring this major contribution to the humanities, the hunters lined up in echelon. Often viewed as renegades, disreputably motivated by size of the bounty, they were really noble citizens, merely dedicated to the purification of society. Within the purviews of ordinary men, the purlieus of the bounty hunter now embrace those fields of corporate medicine that involve readjustment of limb, transmutation of golden brain to alchemical slush, and cutting up generally. Although bounty sizes seem inflationary, one must remember that
Book Review Rook/Wilkinson/Ebling Textbook of Dermatology Sixth edition. Edited by R.H. Champion, J.L. Burton, D.A. Burns, and S.M. Breathnach. 3683 pp. in four volumes, illustrated. Boston, Blackwell Science, 1998. $695. 0-632-03796-2
Authors: Jeffrey P. Callen
Journal: New England Journal of Medicine (1999)
Government confirms transfer of NHS computerisation to local bodies
Authors: M. Cross
Journal: BMJ (2010)

Medical professionals have welcomed the formal announcement of the end of the centrally driven £13bn (€16bn; $20bn) programme to computerise the NHS in England but have asked for more clarity on what will replace it.

In a widely expected statement a junior health minister, Simon Burns, said last week that a review had concluded that “a more locally led, plural approach” should replace national procurement of systems to computerise patients’ records. The Department of Health said that the move would save £700m, mainly by cutting back the scope of existing contracts.

The new policy means that NHS trusts and general practices will be free to choose their systems instead of having to take the one picked by centrally appointed “local service providers.” However, centrally operated systems for handling electronic appointment booking and …
Studies on phosphorylation of canine cardiac sarcoplasmic reticulum by calmodulin-dependent protein kinase.
Authors: L M Bilezikjian, E G Kranias, J D Potter, A Schwartz
Journal: Circulation Research (1981)

Two endogenous protein kinase activities, cAMP-dependent and calmodulin-Ca2+-dependent, are associated with isolated cardiac sarcoplasmic reticulum (SR) vesicles. Both kinases phosphorylate an endogenous substrate of approximately 22,000 daltons (phospholamban). The phosphorylation of phospholamban by either the intrinsic or by exogenous cAMP-dependent protein kinase is found to be Ca2+-independent between 0.05 and 100 microM free Ca2+. Calmodulin-dependent phosphorylation, on the other hand, does not require cAMP and is absolutely dependent on the presence of free Ca2+ over a concentration range that corresponds to physiological levels (10(-7) to 10(-5) M). Phosphorylation of SR vesicles by both kinases is additive and the extent of saturation of the cAMP-specific sites has no effect on the degree of stimulation by calmodulin or its Ca2+-dependence. Trifluoperazine, an inhibitor of calmodulin, inhibits calmodulin-dependent phosphorylation without affecting cAMP-dependent phosphorylation, indicating the presence of two types of kinases. This is made further evident by the selectivity of each kinase for exogenous substrates. Whereas cAMP-dependent protein kinase appears to phosphorylate histone ILA (a basic protein) preferentially, calmodulin-dependent protein kinase prefers phosvitin (an acidic protein).
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population
Authors: Tomomitsu Hirota, Atsushi Takahashi, Michiaki Kubo, Tatsuhiko Tsunoda, Kaori Tomita, Satoru Doi, Kimie Fujita, Akihiko Miyatake, Tadao Enomoto, Takehiko Miyagawa, Mitsuru Adachi, Hiroshi Tanaka, Akio Niimi, Hisako Matsumoto, Isao Ito, Hironori Masuko, Tohru Sakamoto, Nobuyuki Hizawa, Masami Taniguchi, John J Lima, Charles G Irvin, Stephen P Peters, Blanca E Himes, Augusto A Litonjua, Kelan G Tantisira, Scott T Weiss, Naoyuki Kamatani, Yusuke Nakamura, Mayumi Tamari
Journal: Nature Genetics (2011)
Preliminary Experience using Laparoscopic Transcystic Cholangioscopy for Treatment of Common Bile Duct Stones
Authors: K. Ido, K. Kimura, C. Kawamoto, S. Satoh, N. Isoda, Y. Taniguchi, T. Suzuki, M. Ohtani, M. Kumagai, S. Horikawa
Journal: Endoscopy (1992)

Laparoscopic transcystic cholangioscopy (LTC) in combination with electrohydraulic lithotripsy may be an alternative treatment to ERCP and sphincterotomy in patients with both gallbladder and common bile duct stones undergoing laparoscopic cholecystectomy. Preliminary experience using LTC lithotripsy in 13 cases is reported. In 12 cases the stones were pushed out into the duodenum using the tip of the cholangioscope, in 8 of them stone disintegration via LTC lithotripsy also being required. In the remaining case the cholangioscope could not be inserted into the common bile duct via the cystic duct due to complete cystic duct obstruction. The average hospital stay was 9 days (range 6-16) in patients with LTC/lithotripsy, which did not differ significantly from 8.4 days (range, 4-19) (n = 330) in the group undergoing laparoscopic cholecystectomy alone. The patients usually resumed normal activity the day after discharge. LTC lithotripsy has the advantages over endoscopic sphincterotomy of a shorter treatment and preservation of a normal functioning sphincter of Oddi. Further technical improvements, especially the development of a cholangioscope for this purpose, are urgently required.
The γ-Glutamylcysteine Synthetase and Glutathione Regulate Asbestos-induced Expression of Activator Protein-1 Family Members and Activity
Authors: Arti Shukla, Trisha Flanders, Karen M. Lounsbury, Brooke T. Mossman
Journal: Cancer Research (2004)

Abstract Asbestos fibers cause persistent increases in activator protein-1 (AP-1) family member proto-oncogenes in lung epithelial and mesothelial cells that are linked to proliferation and cell transformation. Using lung epithelial cells, the progenitor cells of lung cancers, we report that crocidolite asbestos initially depletes intracellular glutathione followed by up-regulation of both catalytic and modifier subunits of γ-glutamylcysteine synthetase. In vivo asbestos inhalation experiments confirm increased protein levels of γ-glutamylcysteine synthetase in mouse lungs. We also show that asbestos-induced mRNA levels of fos/jun proto-oncogenes, fra-1 transactivation, and AP-1 to DNA binding activity are glutathione-dependent. Epidermal growth factor receptor activity by asbestos is blocked by N-acetyl-l-cysteine, suggesting that it is an initial redox-activated event leading to downstream AP-1 proto-oncogene up-regulation. The overexpression of subunits of γ-glutamylcysteine synthetase in combination completely blocked asbestos-induced up-regulation of AP-1 proto-oncogene expression. However, when overexpressed individually, the modifier subunit had more dramatic effects than the catalytic subunit. Our work shows that the glutathione-controlled redox status of the epithelial cell plays a pivotal role in asbestos-induced epidermal growth factor receptor and proto-oncogene activation as well as AP-1 activity.
Hypokalemia and Arrhythmias in Myocardial Infarction-Reply
Authors: Martin Duke
Journal: JAMA (1978)

<h3>In Reply.—</h3> Although it would seem reasonable to expect that treatment of thiazide-induced hypokalemia with potassium supplements or potassium-sparing agents might prevent some instances of ventricular fibrillation from occurring in the presence of an acute myocardial infarction, my report was not designed to answer this question, and one can only speculate that it might be so. It would be a logical extension of the present study, therefore, to investigate this important problem further by comparing the incidence of myocardial infarction and ventricular fibrillation in patients on diuretics both with and without concurrent treatment with potassium supplements or potassium-sparing agents. I agree with Dr Loewy that prevention of ventricular fibrillation would be far more desirable than treatment at the time of the acute cardiac problem, the latter having been the specific subject matter of the present study. In lieu of such data, however, it would seem appropriate that patients receiving diuretics
MY EXPERIENCE WITH PAQUIN'S ANTITUBERCLE SERUM.
Authors: S. LANE ANDERSON
Journal: JAMA (1897)

I have used Paquin's antitubercle serum on several cases, and for me it has done all that is claimed for it. <h3>Case 1.</h3> —Miss G., aged 25, weight 130 pounds. January and February, 1896, suffered from an attack of la grippe; did not clear up properly. Symptoms three months later, in May, dull and pneumonic areas in right lung amounting to pectoriloquy; acute lancinating pain, purulent expectoration, continuous cough, and exaggerated and very<i>painful tubercular pharyngitis</i>, daily afternoon rise of temperature, excessive night sweats and most offensive diarrhea; had also two hemorrhages in June. My treatment up to this time had been the recognized standard remedies for the existing conditions. A professor of laryngology from one of our colleges in Philadelphia had seen the case and his suggestions had been faithfully carried out, with absolutely no amelioration of the trouble. Two consultants pronounced the trouble advanced tuberculosis. In July, 1896,
Medical Examination of School Children in the City of Cambridge
Authors: Samuel E. Chalfen
Journal: New England Journal of Medicine (1954)

IN September, 1952, "Regulations for the Physical Examination of Pupils in the Public Schools of Massachusetts" went into effect. These regulations, as required by Chapter 502 of the Acts of 1951, were drawn up by the Department of Public Health after consultation with the medical profession and the Department of Education. Their purpose is to provide for more detailed medical examination of children in the public schools of Massachusetts. They do away with the requirement for yearly medical examinations of all pupils. Many groups, particularly the School Health Committee of the Massachusetts Medical Society and representatives of the American Academy . . .
New alarm for treatment of nocturnal enuresis.
Authors: H. J. Terry
Journal: BMJ (1967)

Hospital Admissions among Students-Grant ,", occurring while in statu pupillari, and the contribution of trauma-that is, road traffic accidents-to mortality in this age group is underlined.In some instances the student was dead on arrival at hospital, and these ought strictly, perhaps, to have been excluded from the total of hospital admissions, but the picture would have been incomplete without them.Two students were "found dead" in circumstances which aroused suspicion of suicide-a surprisingly small number bearing in mind the size of the population at risk over a three-year period and experience at other universities (Rook, 1959).