Hepatitis B Immune Globulin: Some Progress and Some Problems
Authors: JAMES W. MOSLEY
Journal: Annals of Internal Medicine (1979)

Editorials1 December 1979Hepatitis B Immune Globulin: Some Progress and Some ProblemsJAMES W. MOSLEY, M.D.JAMES W. MOSLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-6-914 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe discovery at the end of the 1960s that the Australia antigen (now called hepatitis B surface antigen [HBsAg]) is a component of hepatitis B virus (HBV) opened the door to preparation of hepatitis B immune globulin (HBIG) having titers of specific antibody (anti-HBs) many hundredfold times higher than those in standard immune serum globulin (ISG). As rapidly as anti-HBs-rich units of plasma could be identified and batches of HBIG prepared, studies of prophylaxis of type B hepatitis were carried out (1-6). Unfortunately, these investigations did not provide an easily interpretable answer to relative usefulness of HBIG and ISG. Hence,...References1. KRUGMANGILES SJ. Viral hepatitis, type B (MS-2-strain): further observations on natural history and prevention. N Engl J Med. 1973;288:755-60. CrossrefMedlineGoogle Scholar2. SZMUNESSPRINCEGOODMANEHRICHPICKANSARI WAMCRM. Hepatitis B immune serum globulin in prevention of nonparenterally transmitted hepatitis B. N Engl J Med. 1974;290:701-6. CrossrefMedlineGoogle Scholar3. IWARSONAHLMENERIKSSON SJE. Hepatitis B immune globulin in prevention of hepatitis B among hospital staff members. J Infect Dis. 1977;135:473-7. CrossrefMedlineGoogle Scholar4. PRINCESZMUNESSMANN AWM. Hepatitis B immune globulin: final report of a controlled, multicenter trial of efficacy in prevention of dialysis-associated hepatitis. J Infect Dis. 1978;137:131-44. CrossrefMedlineGoogle Scholar5. GRADYLEEPRINCE GVA. Hepatitis B immune globulin for accidental exposures among medical personnel: final report of a multicenter controlled trial. J Infect Dis. 1978;138:625-38. CrossrefMedlineGoogle Scholar6. SEEFFWRIGHTZIMMERMAN LEH. Type B hepatitis after needle-stick exposure: prevention with hepatitis B immune globulin. Ann Intern Med. 1978;88:285-93. LinkGoogle Scholar7. . Immune globulins for protection against viral hepatitis. Morbid Mortal Weekly Rep. 1977;26:425-8, 441-2. Google Scholar8. PRINCE A. Use of hepatitis B immune globulin: reassessment needed. N Engl J Med. 1978;299:198-9. CrossrefMedlineGoogle Scholar9. SEEFFHOOFNAGLE LJ. Immunoprophylaxis of viral hepatitis. Gastroenterology. 1979;77:161-82. CrossrefMedlineGoogle Scholar10. KRUGMANHOLLINGERMOSLEYMAYNARD SFJJ. Immunoprophylaxis for viral hepatitis—other views. Gastroenterology. 1979;77:186-91. CrossrefMedlineGoogle Scholar11. HOOFNAGLESEEFFBALESWRIGHTZIMMERMAN JLZEH. Passive-active immunity from hepatitis B immune globulin: reanalysis of a Veterans Administration cooperative study of needle-stick hepatitis. Ann Intern Med. 1979;91:813-8. LinkGoogle Scholar12. . Prophylactic gamma globulin for prevention of endemic hepatitis: effects of US gamma globulin upon the incidence of viral hepatitis and other infectious diseases in US soldiers abroad. Arch Intern Med. 1971;128:723-37. CrossrefMedlineGoogle Scholar13. GINSBERGCONRADBANCROFTLINGOVERBY AMWCL. Antibody to Australia antigen: detection with a simple radioimmune assay, incidence in military populations, and role in the prevention of hepatitis B with gamma globulin. J Lab Clin Med. 1973;82:317-25. MedlineGoogle Scholar14. GRADYRODMANLARSEN GML. Hepatitis B antibody in conventional γ-globulin. J Infect Dis. 1975;132:474-7. CrossrefMedlineGoogle Scholar15. DOSIKJHAVERI HR. Prevention of neonatal hepatitis B infection by high-dose hepatitis B immune globulin. N Engl J Med. 1978;298:602-3. CrossrefMedlineGoogle Scholar16. ALTERSEEFFKAPLAN HLP. Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure. N Engl J Med. 1976;295:909-13. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Southern California School of Medicine Los Angeles Liver Unit Rancho Los Amigos Hospital Downey, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA Survey of HBs Antigenmia among Healthy Inhabitants in Kyungpook Province, KoreaImmunoprophylaxis of viral hepatitisHepatitis B Immune Globulin and Immune Serum GlobulinPrevention of Hepatitis with Gamma GlobulinMARCEL E. CONRAD, M.D.Hepatitis B im Kindesalter 1 December 1979Volume 91, Issue 6Page: 914-916KeywordsAntigensBlood plasmaGlobulinsHepatitisHepatitis BHepatitis B surface antigenHepatitis B virusImmune serumImmune serum globulinProphylaxis Issue Published: 1 December 1979 PDF DownloadLoading ...