tbuckley/cabot-search huggingface dataset:
Cystatin C
Authors: Tomas Jernberg, Bertil Lindahl, Stefan James, Anders Larsson, Lars-Olof Hansson, Lars Wallentin
Journal: Circulation (2004)

Background— Patients with suspected or confirmed non–ST-elevation acute coronary syndrome (ACS) constitute a large and heterogeneous group. Measurements of renal function such as serum creatinine and estimation of creatinine clearance carry independent prognostic information in this population. Cystatin C is a new and better marker of renal function than creatinine. The aim was therefore to evaluate the prognostic value of cystatin C in this population. Methods and Results— Cystatin C was analyzed on admission in 726 patients admitted because of symptoms suggestive of an acute coronary syndrome and no ST-segment elevations. Patients were followed up with regard to death and myocardial infarction for a median of 40 and 6 months, respectively. The median cystatin C level was 1.00 mg/L (25th to 75th percentile, 0.83 to 1.24 mg/L). The risk of death during follow-up increased with increasing levels of cystatin C. In the group with non–ST-elevation ACS, patients in the second, third, and fourth quartiles had a relative risk of subsequent death of 1.8 (95% CI, 0.6 to 5.3), 3.2 (95% CI, 1.2 to 8.5), and 11.7 (95% CI, 4.7 to 29.3) compared with the lowest quartile. In Cox regression models including well-known predictors of outcome, cystatin C level was independently associated with mortality but not with the risk of subsequent myocardial infarction. In a comparison of the markers of renal function in receiver-operating curve analyses, cystatin C had the best ability to discriminate between survivors and nonsurvivors. Conclusions— A single measurement of cystatin C will substantially improve the early risk stratification of patients with suspected or confirmed non–ST-elevation ACS.
Azathioprine in connective tissue disorders.
Authors: A J Richards, D R Swinson, E B Hamilton
Journal: BMJ (1972)

glands are cholinergic and show muscarinic characteristics.They are therefore blocked by muscarinic antagonists such as atropine but are quite unaffected by alpha blockers.The second point arises from the state- ment that noradrenaline is without direct effect on the myocardium.Although the spectrum of agonist activity of noradren- aline is predominantly alpha it does exhibit some beta activity, and therefore it is false to imagine the myocardium immune from the actions of noradrenaline.-Iam, etc.,
Asymptomatic Bacteriuria, What Are You Treating?
Authors: Jennifer Weiskopf, Serena Scott
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Clinical Work in Public Health
Authors: C. D. L. Lycett
Journal: BMJ (1973)

severe pre-eclampsia may occur early enough to retard fetal growth.It is therefore im- portant to distinguish between pre-eclawpsia and eclampsia in such comparisons.The relatively small percentage of Yoruba primigravidae who are over 25 years of age tend to be overweight and to show a higher than average incidence of pre-eclampsia during pregnancy of the type seen in Europe.These women are usually in non- manual occupations.There is good evidence that hy,pertension is common in Yoruba women in middle life.-I am, etc.,
THE TREATMENT OF WARTS WITH X-RAYS..
Authors: F. F. HELLIER
Journal: British Journal of Dermatology (1951)

Journal Article THE TREATMENT OF WARTS WITH X‐RAYS.: IS THEIR ACTION PHYSICAL OR PSYCHOLOGICAL? Get access F. F. HELLIER, O.B.E., M.A., M.D., F.R.C.P. F. F. HELLIER, O.B.E., M.A., M.D., F.R.C.P. Dermatologist, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 63, Issue 5, 1 May 1951, Pages 193–194, https://doi.org/10.1111/j.1365-2133.1951.tb13710.x Published: 01 May 1951
Abstract B35: Serum inflammatory biomarkers of acute and persistent fatigue in a preclinical breast cancer treatment model
Authors: Lisa J. Wood, Lillian M. Nail, Collin R. Elsea, Brian J. Druker
Journal: Clinical Cancer Research (2010)

Abstract Aims: Cancer treatment related fatigue (CTRF) is a debilitating symptom of cancer chemotherapy. The acute CTRF that occurs during chemotherapy can become persistent lasting for weeks, month, or years after treatment has ended. Although, treatment-related increases in IL-1β and TNF-α have been implicated in CTRF, the role that these cytokines play in CTRF is unclear. The aim of this study was to determine the relationship between chemotherapy-induced IL-1β and TNF-α production and acute and persistent CTRF in a pre-clinical mouse model. Methods: Blood levels of IL-1β, TNF-α and several other inflammatory biomarkers were measured in acutely fatigued, non-fatigued, and persistently fatigued mice following administration of cytoxan-adriamycin-5-fluorouracil (CAF), a commonly used adjuvant chemotherapy regimen for the treatment of breast cancer, by assessing changes in voluntary wheel running activity as a proxy for fatigue. Results: Fatigued mice showed increased blood levels of IL-1β, TNF-α as well as several other inflammatory markers including, IL-5, IL-6, IL-7, IL-9, IP-10, G-CSF, KC, MCP-1 and MIP-1β. Importantly, serum levels of these fatigue associated biomarkers were not significantly increased in non-fatigued CAF treated mice. CAF-treated mice with persistent fatigue had elevated serum levels of IL-6, IL-17, and MIP-1α. Conclusions: This study advances the science of symptom management by providing evidence that treatment induced increases in IL-1β and TNF-α play a role in acute CTRF. Similar temporal analyses between serum inflammatory biomarkers in the clinical setting may lead to a better understanding of the role of immune dysfunction in the etiology of acute and persistent fatigue. Citation Information: Clin Cancer Res 2010;16(7 Suppl):B35
Abstract 4889: Oncolytic adenovirus coated with stimuli responsive block copolymer mPEG-b-poly(His) induces tumor microenvironment-specific antitumor efficacy
Authors: Chae-Ok Yun
Journal: Cancer Research (2014)

Abstract Adenovirus (Ad) has shown great promise in cancer gene therapy. Ad coated with cationic polymers have already been shown to enhance transduction, but it showed nonspecific binding with cells, resulted in evoked side effect. To overcome these hurdles, in this study adenovirus coated with pH sensitive poly(His) polymer through ionic interaction for passive tumor targeting. We have characterized the effect of polymer concentration on particle size distribution, zeta potential, transduction efficiency, and structural properties. Remarkable enhanced transduction efficiency was observed in cells treated with Ad/poly(His) nanocomplex compared to naked Ad at low pH. In addition, cellular trafficking using time lapse total internal reflection fluorescence showed that the Ad/poly(His) nanocomplex was significantly enhanced cellular uptake at lower pH, in contrast to neutral pH. The biodistribution study confirmed that the Ad/poly(His) nanocomplex can effectively accumulate at the tumor site by the EPR effect and exhibited 3.3-fold higher luciferase expressions in tumor than the naked Ad. Additionally, MTT assay and cancer cell xenografts studies showed that polymer coated nanocomplex exhibited high cancer cell killing effect and also inhibited the tumor growth. Furthermore, poly(His)-coated Ad complex was not significantly inhibited by serum, in contrast to naked Ad. Moreover, Ad/poly(His) nanocomplex significantly reduced the innate immune response in contrast to naked Ad, as assessed by interleukin-6 cytokine release from macrophage cells in vivo. These results suggest that the stimuli-responsive Ad/poly(His) nanocomplex has potential to targeting tumors. Note: This abstract was not presented at the meeting. Citation Format: Chae-Ok Yun. Oncolytic adenovirus coated with stimuli responsive block copolymer mPEG-b-poly(His) induces tumor microenvironment-specific antitumor efficacy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4889. doi:10.1158/1538-7445.AM2014-4889
A performance evaluation of the expert system ‘Jaundice’ in comparison with that of three hepatologists
Authors: Calogero Cammà, Germana Garofalo, Piero Almasio, Fabio Tinè, Antonio Craxì, Ugo Palazzo, GiovanBattista Pinzello, Felice Fiorello, Paolo M. Angelo, Luigi Pagliaro
Journal: Journal of Hepatology (1991)
Distinct and Overlapping Functions of Insulin and IGF-I Receptors
Authors: Jun Nakae, Yoshiaki Kido, Domenico Accili
Journal: Endocrine Reviews (2001)

Targeted gene mutations have established distinct, yet overlapping, developmental roles for receptors of the insulin/IGF family. IGF-I receptor mediates IGF-I and IGF-II action on prenatal growth and IGF-I action on postnatal growth. Insulin receptor mediates prenatal growth in response to IGF-II and postnatal metabolism in response to insulin. In rodents, unlike humans, insulin does not participate in embryonic growth until late gestation. The ability of the insulin receptor to act as a bona fide IGF-II-dependent growth promoter is underscored by its rescue of double knockout Igf1r/Igf2r mice. Thus, IGF-II is a true bifunctional ligand that is able to stimulate both insulin and IGF-I receptor signaling, although with different potencies. In contrast, the IGF-II/cation-independent mannose-6-phosphate receptor regulates IGF-II clearance. The growth retardation of mice lacking IGF-I and/or insulin receptors is due to reduced cell number, resulting from decreased proliferation. Evidence from genetically engineered mice does not support the view that insulin and IGF receptors promote cellular differentiation in vivo or that they are required for early embryonic development. The phenotypes of insulin receptor gene mutations in humans and in mice indicate important differences between the developmental roles of insulin and its receptor in the two species.
Sequence analysis of the putative structural genes of hepatitis C virus from Japanese and European origin
Authors: A.M. Delisse, M. Descurieux, T. Rutgers, E. D'Hondt, M. De Wilde, T. Arima, J.M. Barrera-Sala, M.G. Ercilla, J.-L. Ruelle, T. Cabezon
Journal: Journal of Hepatology (1991)
The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.
Authors: K Haskins, C Hannum, J White, N Roehm, R Kubo, J Kappler, P Marrack
Journal: The Journal of Experimental Medicine (1984)

We have prepared a monoclonal antibody, KJ16-133, from the cells of a rat immunized with the purified receptor for antigen plus I-A of a BALB/c T cell hybridoma, DO-11.10. Unlike most other monoclonal anti-receptor antibodies that have been described before, KJ16-133 is not clone specific. It reacts with approximately 20% of the receptors on T cells of normal BALB/c mice. It also reacts with about the same percentage of antigen-specific, major histocompatibility complex (MHC)-restricted or allogeneic I-region specific T cell hybridomas. Reaction of KJ16-133 with a given T cell hybridoma does not seem to depend on the antigen specificity or MHC-restricting element of the T cell in question. The determinant recognized by KJ16-133 has some unexpected properties. It is absent in several strains of mice including SJL/J and SJA/20, but present on the T cells of most other commonly used strains. The determinant recognized therefore does not map to Igh. Our experiments suggest that a clone-specific "antiidiotypic" antibody and KJ16-133 recognize determinants on different parts of the receptor. For example, the binding of a clone-specific antibody to target T cells is relatively temperature insensitive, whereas KJ16-133 binds well to cells at 37 degrees C but poorly to cells at 4 degrees C. The determinant recognized by a clone-specific antibody is sensitive to reduction and alkylation of the receptor, whereas KJ16-133 reactivity is not. Finally, binding of KJ16-133 at saturating concentrations to target T cells does not block the binding of a clone-specific antibody. Similarly, binding of a clone-specific antibody only marginally inhibits binding of KJ16-133. Taken together, these results suggest that KJ16-133 is directed against an allelic determinant on T cells that may be close to the membrane, and not in the receptor binding site for antigen plus MHC. The antibody may recognize an allele of a constant region isotype, or an allele of a J region.
Construction of the Sophia Observation withdrawal Symptoms-scale (SOS) for critically ill children
Authors: Erwin Ista, Monique van Dijk, Matthijs de Hoog, Dick Tibboel, Hugo J. Duivenvoorden
Journal: Intensive Care Medicine (2009)

To construct a reliable and clinically practical instrument for monitoring opioids and benzodiazepine withdrawal symptoms in pediatric ICU patients.Instrument development.Intensive care unit in an academic children's hospital.79 patients up to age 16 years on intravenous midazolam and/or opioids for > or =5 days. An expert panel of 85 physicians and nurses rated clinical relevance of withdrawal symptoms.During drug weaning repeated observations were performed with a checklist of 24 withdrawal symptoms described in the literature.For 76 children, 932 observations were obtained within 24 h after decrease and/or discontinuation of midazolam or opioids. Most frequent symptoms were tachypnea, agitation, motor disturbance, diarrhea, fever, anxiety, sleep disturbance and hypertension (14.6-29.6%). Multidimensional scaling (MDS) was performed to detect the underlying empirical structure of co-occurrences of symptoms. An expert panel judged clinical relevance of each withdrawal symptom on a four-point scale ranging from 'definitively so' to 'definitively not'. Agitation, anxiety, inconsolable crying, increased muscle tension, tremors, tachycardia and sweating were considered relevant by 85-95% of the experts. On the basis of the MDS results and the experts' opinions, 15 symptoms were included in the final instrument.We are the first to develop an assessment tool for withdrawal symptoms in pediatric ICU patients on the basis of the underlying empirical structure of co-occurrences of withdrawal symptoms that experts considered relevant. Future studies need to define cut-off points and clarify psychometric issues.
Morphology of experimental antibiotic-associated enterocolitis in the hamster: a model for human pseudomembranous colitis and antibiotic-associated diarrhoea.
Authors: A B Price, H E Larson, J Crow
Journal: Gut (1979)

The morphology of antibiotic-associated enterocolitis in the hamster is described and compared with human antibiotic-associated pseudomembranous colitis. It is shown to be a caecal disease with proliferative mucosal changes and in this respect unlike the human counterpart. The bacteriology and toxicology, however, are identical. In addition, mucosal changes are described in animals on antibiotics but without established enterocolitis. As a result we suggest that there may be a spectrum of human disease ranging from mild antibiotic-associated diarrhoea to established pseudomembranous colitis. Therefore, despite the morphological variation, the hamster remains a good model for investigating the pathogenesis of pseudomembranous colitis and antibiotic-associated enteropathy in general.
Investigator contact details should continue to be available after completion of clinical trials
Authors: S. O'Neill, S. J. Wigmore, J. E. Fitzgerald, A. Bhangu, E. M. Harrison
Journal: BMJ (2014)

Timely dissemination of research findings is needed for research results to be successfully translated into practice.1 The Food and Drug Administration Amendments Act requires trials that are subject to mandatory reporting to post results within 12 months of study completion on ClinicalTrials.gov.2 Despite this initiative, less than a quarter of trial investigators comply.3

Maruani and colleagues report that email reminders of the legal requirement to post results significantly improved reporting at six months.4 …
Effects of naloxone on auditory hallucinations.
Authors: M Orr, C Oppenheimer
Journal: BMJ (1978)

All three patients now described had psoriasis responsive to haemo- dialysis.The beneficial effect of this treatment is unlikely to be due to coincidence.While McEvoy and Kelly noted that their patient relapsed 11 months after the withdrawal of dialysis, our second patient had psoriasis that reappeared promptly after dialysis was stopped and at a time when immunosuppressive treatment would have been ex- pected to maintain a remission.The delay in the appearance of more extensive psoriasis in case 2 and the ultimate relapse in the patient of McEvoy and Kelly was probably due to and dependent upon the reduction of immunosuppressive treatment required after transplantation.Studies on 14C-thymidine incorporation in DNA of transforming lymphocytes suggest that haemodialysis causes a loss of factors from normal and uraemic plasma that are essential for DNA synthesis.3These changes are independent of any lymphopenia caused by dialysis.Similar blood-borne factors responsible for epidermal DNA synthesis may exist and would explain our observations in psoriasis.
Injuries treated at a sports injury clinic compared with a neighbouring accident and emergency department.
Authors: S Rowell, A Rees-Jones
Journal: British Journal of Sports Medicine (1988)

Previous reports relating to sports injuries treated at hospital Accident and Emergency departments (A&E) or Sports Injury Clinics (SIC) indicate differences between the groups. This study compared directly the sports injuries treated during overlapping time periods at an A&E department (n = 2490) and a SIC (n = 340) set within the same geographical area. The two populations were found to differ significantly in age, sport, injury and injury site. Hospital patients tended to be younger, with an acute injury to the upper body or head which occurred during participation in sports where contact is likely. SIC patients tended to be older, with chronic or overuse injuries to the back or lower limb. It was found that there are significant differences between the sports injuries treated at the sports injury clinic and the hospital casualty department. It is concluded that demand is clearly shown for both types of treatment site when both are available in the same geographical area.
Colonic diverticulitis in chemotherapy patients: Should operative indications change? A retrospective cohort study
Authors: Tushar Samdani, Fredric M. Pieracci, Soumitra R. Eachempati, Jaime Benarroch-Gampel, Alex Weiss, M. Cathy Pietanza, Philip S. Barie, Garrett M. Nash
Journal: International Journal of Surgery (2014)
Postmarketing surveillance of enalapril I
Authors: D Blowers, D Chalmers
Journal: BMJ (1988)

A former member of the United Kingdom Central Council (UKCC) for Nursing, Midwifery and Health Visiting felt that I was "impertinent" to suggest change (15 October, p 981), whereas Ms Sheila Kitzinger believes I did not go far enough,' so I think the balance of the article was about right.May I respond, however, to Mr Reader's point (29 October, p 1125) that the UKCC already includes lay members?Though Mr Reader does not belong to a nursing profession, he was ap- pointed to the UKCC as an educationalist and not as a lay person.Like the UKCC's financial members, its educationalist members were ap- pointed to speak for a particular non-
Constitutional Telomerase-Associated Gene Variants In Pediatric Acute Myeloid Leukemia (AML) and In Association With Chemotherapy-Related Toxicities
Authors: M. Monica Gramatges, Ghadir S. Sasa, Robert B. Gerbing, Eunji Jo, Todd A. Alonzo, Charlotte H Ahern, Soheil Meshinchi, Alison A. Bertuch
Journal: Blood (2013)
The Inferior Vena Cava Filter
Authors: Vinay Prasad, Jason Rho, Adam Cifu
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
ZOTAROLIMUS ELUTING STENT VERSUS SIROLIMUS ELUTING AND PACLITAXEL ELUTING STENT FOR PERCUTANEOUS CORONARY INTERVENTION: A META-ANALYSIS OF RANDOMIZED TRIALS
Authors: Ankur Sethi, Amol Bahekar, Rohit Bhuriya, Param P. Singh, Rohit Arora, Sandeep Khosla
Journal: Journal of the American College of Cardiology (2011)