Reversible Hepatic Decompensation in Primary Biliary Cirrhosis Due to Hypercoagulability
Authors: Hannah M. Lee, Manish Amin, Marshall M. Kaplan, Edward F. Herlihy
Journal: Annals of Internal Medicine (2007)

Letters6 November 2007Reversible Hepatic Decompensation in Primary Biliary Cirrhosis Due to HypercoagulabilityHannah M. Lee, MD, Manish Amin, MD, Marshall M. Kaplan, MD, and Edward F. Herlihy, MDHannah M. Lee, MDFrom Tufts-New England Medical Center, Boston, MA 02111; and Hawthorn Medical Group, New Bedford, MA 02747.Search for more papers by this author, Manish Amin, MDFrom Tufts-New England Medical Center, Boston, MA 02111; and Hawthorn Medical Group, New Bedford, MA 02747.Search for more papers by this author, Marshall M. Kaplan, MDFrom Tufts-New England Medical Center, Boston, MA 02111; and Hawthorn Medical Group, New Bedford, MA 02747.Search for more papers by this author, and Edward F. Herlihy, MDFrom Tufts-New England Medical Center, Boston, MA 02111; and Hawthorn Medical Group, New Bedford, MA 02747.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-9-200711060-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Patients with decompensated liver disease due to primary biliary cirrhosis (PBC) rarely recover without liver transplantation.Objective: To describe 2 sisters with PBC who developed decompensated liver disease associated with a hypercoagulable state (heterozygosity for the factor V Leiden mutation) that resolved with anticoagulation.Case Report: The first patient was a 47-year-old woman with stage II PBC that was diagnosed in 1996. She was asymptomatic, had detectable antimitochondrial antibodies, and had normal serum bilirubin and albumin levels. Despite treatment with ursodiol and colchicine and trials of methotrexate and then prednisone (for a possible overlap syndrome), her liver disease worsened ...References1. Chazouillères O, Wendum D, Serfaty L, Montembault S, Rosmorduc O, Poupon R. Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome: clinical features and response to therapy. Hepatology. 1998;28:296-301. [PMID: 9695990] CrossrefMedlineGoogle Scholar2. Amitrano L, Brancaccio V, Guardascione MA, Margaglione M, Iannaccone L, D'Andrea G, et al. Inherited coagulation disorders in cirrhotic patients with portal vein thrombosis. Hepatology. 2000;31:345-8. [PMID: 10655256] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Hannah M. Lee, MD; Manish Amin, MD; Marshall M. Kaplan, MD; Edward F. Herlihy, MDAffiliations: From Tufts-New England Medical Center, Boston, MA 02111; and Hawthorn Medical Group, New Bedford, MA 02747.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssociations of Coagulation Factor V Leiden and Prothrombin G20210A Mutations With Budd–Chiari Syndrome and Portal Vein Thrombosis: A Systematic Review and Meta-analysisManagement of portal vein thrombosis in liver cirrhosis 6 November 2007Volume 147, Issue 9Page: 675KeywordsAlbuminsBilirubinColchicineFactor V LeidenLiver diseasesPlateletsPortal hypertensionPortal veinsSerum albuminThrombosis ePublished: 6 November 2007 Issue Published: 6 November 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...