tbuckley/cabot-search huggingface dataset:
Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury
Authors: Megumi Miyabe, Koji Ohashi, Rei Shibata, Yusuke Uemura, Yasuhiro Ogura, Daisuke Yuasa, Takahiro Kambara, Yoshiyuki Kataoka, Takashi Yamamoto, Kazuhiro Matsuo, Yusuke Joki, Takashi Enomoto, Satoko Hayakawa, Mizuho Hiramatsu-Ito, Masanori Ito, Maurice J.B. Van Den Hoff, Kenneth Walsh, Toyoaki Murohara, Noriyuki Ouchi
Journal: Cardiovascular Research (2014)

It is well-established that exercise diminishes cardiovascular risk, but whether humoral factors secreted by muscle confer these benefits has not been conclusively shown. We have shown that the secreted protein follistatin-like 1 (Fstl1) has beneficial actions on cardiac and endothelial function. However, the role of muscle-derived Fstl1 in proliferative vascular disease remains largely unknown. Here, we investigated whether muscle-derived Fstl1 modulates vascular remodelling in response to injury. The targeted ablation of Fstl1 in muscle led to an increase in neointimal formation following wire-induced arterial injury compared with control mice. Conversely, muscle-specific Fstl1 transgenic (TG) mice displayed a decrease in the neointimal thickening following arterial injury. Muscle-specific Fstl1 ablation and overexpression increased and decreased, respectively, the frequency of BrdU-positive proliferating cells in injured vessels. In cultured human aortic smooth muscle cells (HASMCs), treatment with human FSTL1 protein decreased proliferation and migration induced by stimulation with PDGF-BB. Treatment with FSTL1 enhanced AMPK phosphorylation, and inhibition of AMPK abrogated the inhibitory actions of FSTL1 on HASMC responses to PDGF-BB. The injured arteries of Fstl1-TG mice exhibited an increase in AMPK phosphorylation, and administration of AMPK inhibitor reversed the anti-proliferative actions of Fstl1 on the vessel wall. Our findings indicate that muscle-derived Fstl1 attenuates neointimal formation in response to arterial injury by suppressing SMC proliferation through an AMPK-dependent mechanism. Thus, the release of protein factors from muscle, such as Fstl1, may partly explain why the maintenance of muscle function can have a therapeutic effect on the cardiovascular system.
Campaign seeks to make Britons active every day
Authors: N. Hawkes
Journal: BMJ (2014)

“Hold meetings standing up,” urged Kevin Fenton of Public Health England at the launch of a new drive to make Britons more active. 

“Or hold them while taking a walk,” he added, claiming that this was already common practice at the organisation where he is national director of health and wellbeing. As one of the many “simple things” that people could do to change their lifestyle, holding meetings standing up often had the additional benefit of reducing their length, he said.

Fenton, who is tall and persuasive enough to dominate any standing meeting he might attend, was introducing Public Health England’s “Everybody Active, Every Day” campaign.1 It seeks to reverse the trend of diminishing physical activity brought about by changing lifestyles and job patterns—a trend in …
A SULPHOSALT OF THE ALIPHATIC CREOSOTE-ESTERS, AND ITS THERAPEUTIC USEFULNESS.
Authors: HEINRICH STERN
Journal: JAMA (1900)

Early in May, 1898, Dr. G. Wendt, of Berlin, the manufacturer of a series of sulpho-acid salts of the aliphatic creosote-esters, through his American agents,<sup>1</sup>placed some of his products in my hands for therapeutic investigation. In responding to the kind invitation of your secretary, I grasped the opportunity to report at this meeting the therapeutic qualities of one of these salts. Besides the lime salt, of which I shall presently speak, a salt of silver, argentum eosolicum, C<sub>6</sub>HOCH<sub>3</sub>OC<sub>2</sub>H<sub>3</sub>OAG<sub>3</sub>(SO<sub>3</sub>)<sub>3</sub>, resp. C<sub>9</sub>, H<sub>7</sub>, Ag<sub>3</sub>, S<sub>3</sub>, O<sub>12</sub>and one of quinin, chininum eosolicum, (C<sub>9</sub>H<sub>7</sub>S<sub>3</sub>O<sub>12</sub>) (C<sub>20</sub>H<sub>24</sub>N<sub>2</sub>O<sub>2</sub>)<sub>3</sub>, were given to me in order to determine their therapeutic usefulness. Experimental work of another nature, however, prevented me from taking up the latter
Hematemesis After Reserpine for Raynaud's Phenomenon
Authors: EZRA SHARON
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 September 1972Hematemesis After Reserpine for Raynaud's PhenomenonEZRA SHARON, M.D., JAMES S. PAOLINO, M.D., DAVID KAPLAN, M.D.EZRA SHARON, M.D.Search for more papers by this author, JAMES S. PAOLINO, M.D.Search for more papers by this author, DAVID KAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-3-479 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The efficacy of intra-arterial reserpine in the treatment of patients with Raynaud's phenomenon has been shown (1-3). The reported side effects related to this treatment were usually mild; the expected systemic features, such as hypotension, bradycardia, and nasal stiffness, were rarely encountered.We recently treated 12 patients who had scleroderma and Raynaud's phenomenon with an injection of 1 mg of reserpine into a brachial artery. Side effects included transient hypotension (2 cases), mild depression (1 case), and an episode of hematemesis within 2 hours of the intra-arterial injection (2 cases). Hematemesis after intra-arterial reserpine has not been...References1. WILLERSONTHOMPSONHOOKMAN JRP: Reserpine in Raynaud's disease and phenomenon. Short-term response to intra-arterial injection. Ann Intern Med 72:17-27, 1970 LinkGoogle Scholar2. ROMEOWHALENTINDALL SRJ: Intra-arterial administration of reserpine: its use in patients with Raynaud's disease or Raynaud's phenomenon. Arch Intern Med 125:825-829, 1970 CrossrefMedlineGoogle Scholar3. ABBOUDECKSTEINLAWRENCE FJM: Preliminary observations on the use of intra-arterial reserpine in Raynaud's phenomenon. Circulation 35:11-49, 1967 Google Scholar4. PAOLINOSHARONKINKHABWALA JEM: Arteriographie evaluation of intra-arterial reserpine in Raynaud's phenomenon (abstract). Program of the 36th Annual Meeting of the ARA, 8-9 June 1972, Dallas, Tex. Google Scholar1. WILLERSONDECKER JJ: Raynaud's disease and phenomenon, a medical approach. Am Heart J 82:572-573, 1971 CrossrefMedlineGoogle Scholar2. KONTOSWASSERMAN HA: Effect of reserpine in Raynaud's phenomenon. Circulation 39:259-266, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine State University of New York Downstate Medical Center Brooklyn, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLooking beyond 5-HT3 receptors: A review of the wider role of serotonin in the pharmacology of nausea and vomitingToxic Effects of Adrenergic Nerve-End Inhibitors, Neural-Transmitter Depleting Agents and False Transmitters 1 September 1972Volume 77, Issue 3Page: 479-480KeywordsArteriesBradycardiaHypotensionPatientsRaynaud syndromeReserpineSclerodermaStiffness Issue Published: 1 September 1972 PDF downloadLoading ...
Cutaneous malignant melanoma and oculodermal melanocytosis (nevus of Ota): Report of a case and review of the literature
Authors: Bhupendra C.K. Patel, Conleth A. Egan, Richard W. Lucius, John W. Gerwels, Nick Mamalis, Richard L. Anderson
Journal: Journal of the American Academy of Dermatology (1998)
A Double-Blind Placebo-Controlled Study of Intravenous Clodronate for Prevention of Steroid-Induced Bone Loss in Inflammatory Bowel Disease
Authors: Vered Abitbol, Karine Briot, Christian Roux, Carine Roy, Philippe Seksik, Antoine Charachon, Yoram Bouhnik, Benoit Coffin, Matthieu Allez, Dominique Lamarque, Stanislas Chaussade
Journal: Clinical Gastroenterology and Hepatology (2007)
Why is capacity limited? Missing dynamics and developmental controversies
Authors: Richard A. Heath, Brett K. Hayes
Journal: Behavioral and Brain Sciences (1998)

The discovery of a quaternary complexity limitation to mature cognitive operations raises important theoretical issues. We propose that cognitive limitations arise naturally in a complex dynamic information processing system, and consider problems such as the distinction between parallel and serial processes and the representativeness of the empirical data base used by Halford et al. to support their relational complexity scheme.
Perforin-secreting killer cell infiltration and expression of a 65-kD heat-shock protein in aortic tissue of patients with Takayasu's arteritis.
Authors: Y Seko, S Minota, A Kawasaki, Y Shinkai, K Maeda, H Yagita, K Okumura, O Sato, A Takagi, Y Tada
Journal: Journal of Clinical Investigation (1994)

Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of vascular cell injury in Takayasu's arteritis. To clarify the immunological mechanisms involved, we examined the expression of a cytolytic factor, perforin in infiltrating cells of aortic tissue samples from seven patients with Takayasu's arteritis. We also examined the expression of a 65-kD heat-shock protein (HSP-65), human leukocyte antigen classes I and II, and intercellular adhesion molecule-1 in the aortic tissue. Immunohistochemical studies showed that the infiltrating cells mainly consisted of gamma delta T lymphocytes, natural killer cells, macrophages, cytotoxic T lymphocytes and T helper cells, and that perforin was expressed in gamma delta T lymphocytes, natural killer cells, and cytotoxic T lymphocytes. In situ hybridization analysis also revealed expression of perforin mRNA in the infiltrating cells. Immunoelectron microscopic studies demonstrated that the infiltrating cells released massive amounts of perforin directly onto the surface of arterial vascular cells. We also found that expression of HSP-65, human leukocyte antigen classes I and II, and intercellular adhesion molecule-1 was strongly induced in the aortic tissue and might facilitate the recognition, adhesion and cytotoxicity of the infiltrating killer lymphocytes. These findings provide the first direct evidence that the infiltrating cells in the aortic tissue mainly consist of killer cells, and strongly suggest that these killer cells, especially gamma delta T lymphocytes, may recognize HSP-65 and play a critical role in the vascular cell injury of Takayasu's arteritis by releasing perforin.
Studies of Rubella and Its Prevention With Immune Globulin
Authors: Theodore C. Doege
Journal: JAMA (1967)

During a rubella epidemic the effects of immune globulin (0.5 cc/kg of body weight) on rash, virus-shedding, and serologic conversion were prospectively tested. If virus excretion or a fourfold titer increase represent infection, then 34 of 43 persons were infected, of whom ten had apparent disease, giving a ratio of two inapparent infections for every apparent infection. The difference in rates of infection between test and control groups was insignificant, but fewer virus isolations were made in the test group than in the control group. Virus isolations and occurrence of rash were inversely related to baseline antibody levels. Isolates were made as early as 12 days before and as late as 45 days after the appearance of rash. A 16-year-old girl with the congenital rubella syndrome had a rubella reinfection. Generalized adenopathy, enanthem, mild fever, leukopenia, and an increased sedimentation rate were features of the acute illness.
Chronic Urethrocystitis In Women
Authors: B. G. Clarke
Journal: JAMA (1967)

To the Editor:—  In Treatment of the Urethral Syndrome in Women ( 184 :984, 1963), Robert Zufall, MD, described a group of patients with urinary frequency, dysuria, and other symptoms of inflammation of the lower urinary tract in whom corroborative physical and laboratory findings were minimal if not absent altogether. He wrote, The urethra has been commonly blamed for this syndrome, and many experienced observers find urethral stenosis, edema, hyperemia, granularity, polyps at the neck of the bladder, or exudate on the trigone, but noted himself, For the majority of patients in this series, diligent search revealed nothing at all different from the urethras, bladder necks, and trigones of patients who were cystoscoped for unrelated conditions, who had no 'urethral' symptoms. About one third of his patients improved for more than 12 weeks with any form of treatment tried, including intramuscular injections of sterile water.  To determine quantitatively whether or not
MRI and CT Scan in Multiple Sclerosis
Authors: Charles M. Poser
Journal: JAMA (1985)

To the Editor.—  The recent discussion 1 of the value of magnetic resonance imaging (MRI) in multiple sclerosis that appeared in JAMA is somewhat misleading.  While it is undoubtedly true that MRI may reveal many more lesions than the enhanced computed tomographic (CT) scan, there are instances where a double-dose delayed enhanced CT scan has shown lesions that were not seen by either inversion recovery or spin echo. 1 More important, however, is the fact that contrast enhancement of the CT scan gives information regarding activity of the disease process (in fact the only such evidence) that as yet MRI does not. 2   The two procedures provide different types of data. One would hope that at some time in the future, MRI will be able to reflect the state of the blood-brain barrier and thus replace the enhanced CT scan.  The CT remains the only means for evaluating the effects
Recurrent Pneumonia in Behçet's Syndrome
Authors: Thomas L. Petty
Journal: JAMA (1977)

THE PULMONARY manifestations of Behçet's syndrome have recently been reviewed with a detailed case report added to 12 previously reported cases.<sup>1</sup>Diffuse bilateral pulmonary infiltrations with hemoptysis were the presenting clinical features in ten of the previously reported cases. Serious extensive pulmonary infiltration and, at times, life-threatening hemoptysis in Behçet's syndrome were stressed. A recent patient presented a different clinical picture of recurrent, usually unilateral pneumonia reported during a 13-year period. Despite longstanding recurrent pulmonary involvement, neither severe hemoptysis nor respiratory insufficiency developed. <h3>Report of a Case</h3> A 48-year-old woman was examined because of bouts of recurrent pneumonia. She had episodes of croup during childhood and numerous bouts of pneumonia beginning in her 20s. Each episode was characterized by chilly sensations, fever, cough, but no sputum production. Roentgenogram verification of pneumonia dated to 1956, and the patient estimated that she had at least ten episodes of pneumonia requiring medical
Epidemics predicted for hurricane zone
Authors: Z. Kmietowicz
Journal: BMJ (1998)

The aid package promised to Central America after the devastation of theregion by Hurricane Mitch is inadequate to prevent the spread of disease and famine, a doctor working on a medical relief programme in the flood zone claimed last week.

Dr Nadine Ezard, a public health consultant from Melbourne, said to the BMJ last week: “We are now into the third week of this crisis, and we are getting a sense that the international response has not been adequate. People have survived the hurricane and flood, but unless we are able to get systems in place to respond to outbreaks of disease they will be facing epidemic diseases as well.”

Dr Ezard, who …
Giant orf in a patient with chronic lymphocytic leukaemia
Authors: S. HUNSKAAR
Journal: British Journal of Dermatology (1986)

A case of orf is presented in a patient with chronic lymphocytic leukaemia treated with chlorambucil and prednisone. Diagnosis was confirmed by electron microscopy and histopathology. Human orf is normally a self-limiting and benign condition but in this case the lesion grew to a size of 60 X 60 X 28 mm. When it was excised, local recurrence was treated with topical idoxuridine.
Different patterns of skin manifestations associated with parvovirus B19 primary infection in adults
Authors: Valentia Mage, Dan Lipsker, Sébastien Barbarot, Didier Bessis, Olivier Chosidow, Pascal Del Giudice, Sélim Aractingi, Jérôme Avouac, Claire Bernier, Vincent Descamps, Nicolas Dupin
Journal: Journal of the American Academy of Dermatology (2014)
George Logan — Agrarian, Pamphleteer, Amateur Diplomat
Authors: Hastings K. Wright
Journal: New England Journal of Medicine (1955)

ON the basis of the first twenty-eight years of George Logan's life one would have predicted a sedate and successful career for him as a Philadelphia physician. Indeed, he had all the necessary qualifications: a famous Pennsylvania name, an independent fortune, an unparalleled medical education and a will to succeed. Yet his life took him far afield from medicine into the political arenas of the day, caused him to be expelled from the Society of Friends and labeled a seditionist by the press, and even inspired the Congress of the United States to enact a law expressly aimed at him. . . .
Pathogenesis of paradoxical hypertension after coarctation resection.
Authors: A P Rocchini, A Rosenthal, A C Barger, A R Castaneda, A S Nadas
Journal: Circulation (1976)

The pathogenesis of paradoxical hypertension after resection of coarctation of the aorta was investigated by comparing the course of seven children undergoing repair of coarctation with five acyanotic children undergoing elective cardiovascular surgery. During the first 24 hours after surgery, all coarctation patients demonstrated a rise in systolic blood pressure (35 +/- 15.5 mm Hg; P less than 0.001), a significant depression in cold pressor test response, and only a slight elevation in plasma renin activity. In the next 24-72 hours, coarctation patients developed a rise in diastolic blood pressure (26.8 +/- 10.6 mm Hg; P less than 0.001), plasma renin activity (22.9 +/- 10.2/ml/hr; P less than 0.001) and fluid retention. By contrast, control patients had no significant postoperative changes. Abdominal pain occurred in five coarctation patients during the period of maximal plasma renin activity. The data suggest that the sympathetic nervous system may be responsible for the initial phase of hypertension after coarctation resection and that the renin angiotension system plays a major role in the second phase of hypertension and in the pathogenesis of mesenteric arteritis.
A COMPARISON OF TWO METHODS OF ADMINISTERING ARSENO-BENZOL COMPOUNDS IN SYPHILIS
Authors: H. E. Gibson
Journal: BMJ (1920)

JOBMAI have always used the hydrochloride if obtainable, but if only five grains dailv, the clheaper salts are just as satisfactory.As soon as the patient can get about, some combination of arsenic in increasing doses and iron in small doses has proved most useful.
Hypocalcemia and Parathyroid Hormone in Pancreatitis
Authors: GILES M. ROBERTSON
Journal: Annals of Internal Medicine (1976)

Comments and Correction1 May 1976Hypocalcemia and Parathyroid Hormone in PancreatitisGILES M. ROBERTSON JR., M.D., KARL E. PEACEGILES M. ROBERTSON JR., M.D.Search for more papers by this author, KARL E. PEACESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-5-616_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the August issue (Ann Intern Med 83:185-189, 1975), Weir and associates reported studies on 11 patients with acute pancreatitis; 8 patients had decreased serum ionized calcium, and parathyroid hormone (PTH) concentrations were elevated in 6 and undetectable in 5. They state, "the data obtained from our study indicate that hypocalcemia in acute pancreatitis is not the result of abnormalities of secretion of gastrin, glucagon, or parathyroid hormone."Their conclusion regarding PTH seems to be based upon the demonstration of significant correlation (r = 0.487 and P < 0.025) between ionized calcium (Ca++) and PTH and assuming...References1. FREUND J: Mathematical Statistics. Englewood Cliffs, New Jersey, Prentice-Hall, Inc., 1962, p. 310 Google Scholar2. CONOVER W: Practical Nonparametric Statistics. New York, John Wiley and Sons, 1971, p. 249 Google Scholar3. KENDALL M: Rank Correlation Methods. Riverside, New Jersey, Hafner Publishing Company, 1962, p. 35 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GILES M. ROBERTSONJR., M.D.; KARL E. PEACEAffiliations: Department of Biostatistics Medical College of Virginia Richmond, VA 23298 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1976Volume 84, Issue 5Page: 616-616KeywordsAcute pancreatitisAttentionCalciumGastrinGlucagonHypocalcemiaPancreatitisParathyroid hormone ePublished: 1 December 2008 Issue Published: 1 May 1976 PDF downloadLoading ...
Repetitive responses to single ventricular extrastimuli in patients with serious ventricular arrhythmias: incidence and clinical significance.
Authors: J N Ruskin, J P DiMarco, H Garan
Journal: Circulation (1981)

Electrophysiologic studies were carried out in 85 patients with serious ventricular arrhythmias: 44 with recurrent sustained ventricular tachycardia (group A), 16 with recurrent nonsustained ventricular tachycardia (group B), and 25 with recent prehospital ventricular fibrillation not associated with acute myocardial infarction (group C). Programmed ventricular stimulation from the right ventricular apex included premature stimulation during normal sinus rhythm, atrial pacing, and ventricular pacing, as well as brief bursts of rapid ventricular pacing (RVP). A repetitive ventricular response (RVR) was defined as one or more non-stimulated premature ventricular depolarizations in response to a single paced premature ventricular depolarization during normal sinus rhythm or atrial pacing. RVRs were observed in seven of 44 (16%) group A patients, one of 16 (6%) group B patients, and three of 25 (12%) group C patients. In contrast, single and double premature ventricular stimuli during ventricular pacing and/or bursts of RVP resulted in the reproducible initiation of ventricular tachycardia in 40 of 44 (91%) group A patients, 10 of 16 (63%) group B patients, and 19 of 25 (76%) group C patients. We conclude that RVRs to single ventricular extrastimuli during normal sinus rhythm or atrial pacing are rare, and therefore are an insensitive index of susceptibility to serious ventricular arrhythmias in these patients.