tbuckley/cabot-search huggingface dataset:
Testicular Function in Patients With Testicular Cancer Treated With Orchiectomy Alone or Orchiectomy Plus Cisplatin-Based Chemotherapy
Authors: P. V. Hansen, H. Trykker, P. E. Helkjaer, J. Andersen
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Testicular Function in Patients With Testicular Cancer Treated With Orchiectomy Alone or Orchiectomy Plus Cisplatin-Based Chemotherapy Get access Peter Vejby Hansen, Peter Vejby Hansen * Danish Cancer Society, Department of Experimental Clinical OncologyÅrhus, DenmarkDepartments of Oncology and Clinical Chemistry, Aalborg Municipal HospitalAalborg, Denmark *Dr. Peter Vejby Hansen, Department of Experimental Clinical Oncology, Danish Cancer Society, Nørrebrogade 44, DK-8000 Arhus C, Denmark. Search for other works by this author on: Oxford Academic PubMed Google Scholar Henrik Trykker, Henrik Trykker Departments of Oncology and Clinical Chemistry, Aalborg Municipal HospitalAalborg, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar Poul Erik Helkjær, Poul Erik Helkjær Departments of Oncology and Clinical Chemistry, Aalborg Municipal HospitalAalborg, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar Jørn Andersen Jørn Andersen Danish Cancer Society, Department of Experimental Clinical OncologyÅrhus, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 16, 16 August 1989, Pages 1246–1250, https://doi.org/10.1093/jnci/81.16.1246 Published: 16 August 1989 Article history Received: 07 February 1989 Revision received: 12 May 1989 Accepted: 16 May 1989 Published: 16 August 1989
Seasonal Arsenic Exposure From Burning Chromium-Copper-Arsenate-Treated Wood
Authors: Henry A. Peters
Journal: JAMA (1984)

All eight members of a rural Wisconsin family experienced recurring neurological and medical illness over three years, especially during the winter months. Arsenic, in concentrations of 12 to 87 ppm, was noted in the hair of the mother and father, and analysis of hair and fingernails of all family members demonstrated pathological levels of arsenic. For four years the five-room home had been heated with a small wood stove in which outdoor or marine plywood and wood remnants had been preferentially burned. Stove ashes that contained more than 1,000 ppm of arsenic contaminated the living area, and the ratio of copper, chromium, and arsenic pentoxide in this ash matched the ratio used in the chromium-copper-arsenate-treated wood.
Operative Surgery: Principles and Techniques
Authors: Ben Eiseman
Journal: JAMA (1972)

If you were the astrosurgeon designated for a long space trip, this would be the reference book to take along. Prerequisites would be one year of surgical residency, plenty of reserve rocket booster power (its 1,106 pages weigh 3,000 gm), and $58.00. It has a little of everything in it from reminders how to tie knots and do paracentesis to techniques in closing ventricular septal defect. The book is a compromise. It lies midway between an atlas of techniques and a text. It further compromises by covering not only all fields of general, thoracic, pediatric, vascular, and cardiac surgery but also touches base in gynecology, orthopedics, and urology. Obviously, it cannot compete with atlases or specialty textbooks in any one of these fields, but as a compromise for the surgical generalist it is excellent. With 73 contributors making up, as its advertisement proclaims, "virtually a who's who" in American surgery,
When Should F-18 FDG PET/CT Be Used Instead of 68Ga-DOTA-Peptides to Investigate Metastatic Neuroendocrine Tumors?
Authors: Chiara Fuccio, Alessandra Musto, Silvia Cambioli, Paolo Castellucci, Maria A. Pantaleo, Cristina Nanni, Gian C. Montini, Davide Campana, Paolo Tomassetti, Elena Bellan, Arianna Massaro, Gaia Grassetto, Domenico Rubello, Stefano Fanti
Journal: Clinical Nuclear Medicine (2011)

A 67-year-old man, previously operated for a pancreatic neuroendocrine tumor (NET), had progressive increase of serum chromogranin A during follow-up. Sequential 68Ga-DOTA-NOC and F-18 FDG PET/CT were performed. 68Ga-DOTA-NOC imaging was negative, whereas F-18 FDG PET/CT showed 2 hypermetabolic hepatic lesions demonstrated at CT-guided biopsy as metastatic deposits from a high-grade (G3) aggressive NET. Despite the large consensus of SPECT or PET with radiolabeled somatostatin analogs as first choice in functional imaging for detecting NETs metastasis, F-18 FDG may occasionally be the right tracer to provide accurate diagnostic and prognostic information in aggressive G3 NET.
Some Social Factors Related to Control of Diabetes Mellitus in Adult Jamaican Patients
Authors: Sylvan I Alleyne, Errol Y ST A Morrison, Rolf R Richards
Journal: Diabetes Care (1979)

A population of 103 adult diabetic patients was interviewed at the Outpatient Clinic for diabetic patients of the University Hospital of the West Indies to examine the effects of severity of the illness and social variables, such as facilities at home, education attained, employment status, informal medication, and understanding of the illness in relation to its control. Patients were classified as severe if there were clinical evidence of vascular or neurologic complications of diabetes and as mild if there were no complications. Control of diabetes was regarded as good if the patients were free from or had less than 2+ glycosuria and as poor if they had had 2+ or more glycosuria during the six months before the study. We found that the quality of control was mainly determined by the severity of the disease. In the mild diabetic, proper diabetic control was not influenced by any social variable examined. In the severe diabetic the quality of control was associated with social amenities, educational status, employment status, and understanding of the disease.
An adenosine triphosphate-dependent calcium uptake pump in human neutrophil lysosomes.
Authors: M S Klemper
Journal: Journal of Clinical Investigation (1985)

Regulation of the cytosolic free calcium concentration is important to neutrophil function. In these studies, an ATP-dependent calcium uptake pump has been identified in human neutrophil lysosomes. This energy-dependent Ca++ uptake pump has a high affinity for Ca++ (Michaelis constant [Km] Ca++ = 107 nM) and a maximum velocity (Vmax) of 5.3 pmol/mg of protein per min. ATP was the only nucleotide that supported Ca++ uptake by lysosomes. The Km for ATP was 177 microM. ATP-dependent Ca++ uptake by neutrophil lysosomes was temperature- and pH-sensitive with optimal Ca++ pump activity at 37 degrees C and pH 7.0-7.5. Mg++ was also essential for ATP-dependent Ca++ uptake by lysosomes. Azide and antimycin A had no effect on the energy-dependent uptake of Ca++ by neutrophil lysosomes. The chemotactic peptide formyl-methionyl-leucyl-phenylalanine inhibited ATP-dependent Ca++ accumulation by isolated lysosomes. Butoxycarbonyl-phenylalanine-leucine-phenylalanine-leucine-phenylalanine , a competitive antagonist of the chemotactic peptide, blocked this inhibitory effect. These studies demonstrate the presence of an ATP-dependent Ca++ uptake pump in human neutrophil lysosomes that functions at physiologic intracellular concentrations of Ca++, ATP, and H+ and may be important to regulating neutrophil function by modulating cytosolic Ca++.
Pregnancy and lactation after pituitary surgery.
Authors: S Franks, R Kiwi, J D Nabarro
Journal: BMJ (1977)

An initial M pneumoniae complement-fixing antibody titre was 1/1028; two weeks later the titre was again 1/1028, indicating a recent infection.The reagents for the prolactin assay were generously supplied by the National Pituitary Agency of the United States of America.
Trends in Clinical and Basic Amyloid Research
Authors: Alan S. Cohen
Journal: New England Journal of Medicine (1971)

After 100 years of slow progress, research on amyloid disease has come of age along with the many technical advances of the past decade. Since the detailed review in the Journal,1 the concept of the apparent clinical rarity of amyloidosis gave way to a concept of its virtual universality, especially as an accompaniment of aging.2 The careful clinical study by Ozdemir, Wright and Calkins in this issue raises appropriately the need for a more scientific approach to our clinical as well as basic thinking concerning its incidence. The idea that widespread amyloid may not be common in rheumatoid arthritis . . .
RELATIONSHIP OF OBESITY TO CORONARY DISEASE AND HYPERTENSION
Authors: Arthur M. Master
Journal: JAMA (1953)

For many years, the relationship between obesity and heart disease and hypertension has presented a challenging problem. The physiological effects of obesity on the normal heart and its harmful influences on the diseased heart are well established. 1   Statistics compiled by insurance companies have shown conclusively that overweight alone is injurious and shortens life. 2 In middle and later life the lowest mortality ratios were observed in those whose weight was below the average for age. 3 There is overwhelming evidence, also, that obese persons have a much higher mortality rate from heart disease than those of average or lower weight. The difference has been as high as 60% for men who are 25% or more overweight. 4   There have been few clinical studies on a possible etiological relationship between obesity and coronary disease and hypertension, and the results reported have been conflicting. The problem of the relationship of obesity
Accentuate the Positive
Authors: Robert F. Rushmer
Journal: JAMA (1968)

Technological advances supply physicians with progressively increasing quantities of numerical data from laboratory tests performed on samples of blood and other fluids obtained from patients. If laboratory testing is comprehensive, abnormal values occur rarely in relation to the total quantity of information reported. Thus, the values which vary significantly from normal are buried in a mass of redundant data. Quantitative data regarding patients should be presented to physicians by techniques which emphasize abnormality, suppress redundancy, and reduce the need for mental computations or guesswork about their significance.
The Dreams of Benjamin Rush
Authors: CARL A. L. BINGER
Journal: American Journal of Psychiatry (1969)

Although Benjamin Rush disclaimed any tendency toward superstitious belief in dreams, he seems in fact often to have fallen under the spell of his own dreams and to have been quite affected by them. A common theme in Rush's dreams was the attempt to reconcile a conflict he was then experiencing: the struggle between his humanitarian sentiments and his need to earn a living, for example, and the frequent incompatibility of his personal political ambitions with his role as a doctor.
The Hawksley random zero sphygmomanometer. No harm done.
Authors: H Tunstall-Pedoe
Journal: BMJ (1993)

<h3>Objective</h3> This study aimed to determine the benefits of adjuvant therapy in patients with resected biliary tract cancer (BTC) and identify the optimal adjuvant treatment scheme. <h3>Design</h3> Systematic review and network meta-analysis. <h3>Data sources</h3> Studies comparing different adjuvant therapies in patients with BTC were searched in PubMed, Embase, CINAHL, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov databases from inception to December 2021. Additionally, the references were manually searched for the related literature. <h3>Materials and methods</h3> Eligible studies were identified, and data were extracted independently by two authors. A random-effects network meta-analysis was performed using R software. The pooled outcomes of overall survival (OS) and disease-free survival (DFS) were measured using the combined HRs with 95% CIs. <h3>Results</h3> Nineteen eligible studies reporting three types of adjuvant therapies were included in our network meta-analysis. Adjuvant radiotherapy (ART, HR 0.62; 95% CI 0.42 to 0.93), adjuvant chemoradiotherapy (ACRT; HR 0.71; 95% CI 0.54 to 0.83) and adjuvant chemotherapy (ACT; HR 0.84; 95% CI 0.68 to 0.98) were more effective in prolonging OS than that of observation, with no significant difference between the three adjuvant therapies. Moreover, the improvement in DFS was also found in ACRT and ACT compared with that of observation (HR 0.60; 95% CI 0.45 to 0.75; HR 0.82; 95% CI 0.68 to 0.97, respectively). Furthermore, ACRT obtained a slightly better DFS benefit compared with that of ACT (HR 0.73; 95% CI 0.53 to 0.95). <h3>Conclusions</h3> Our primary results demonstrated that, compared with that of observation, ACRT and ACT after radical resection could provide better OS and DFS benefits in patients with BTC. However, ART only showed improvement in OS, but not in DFS. Due to the lack of head-to-head studies of ACT, ACRT and ART, the above results need to be further verified by prospective randomised controlled trials.
The ratio of plasma high-density lipoprotein cholesterol to total and low-density lipoprotein cholesterol: age-related changes and race and sex differences in selected North American populations. The Lipid Research Clinics Program Prevalence Study.
Authors: M S Green, G Heiss, B M Rifkind, G R Cooper, O D Williams, H A Tyroler
Journal: Circulation (1985)

The distribution of the ratios of plasma high-density lipoprotein cholesterol (HDL-C) to total cholesterol (TC) and of HDL-C to low-density lipoprotein cholesterol (LDL-C) are presented for 6900 white and 495 black examinees greater than 4 years old. Measurements were obtained during the visit 2 survey of the Lipid Research Clinics (LRC) Program Prevalence Study, and correspond to a 15% random sample of 60,502 participants screened during the LRC visit 1 survey. Age-specific means, medians, and selected percentiles are given by sex and by gonadal hormone use in white women. Apparent in these cross-sectional data was a consistent age-related decline in the ratio of HDL-C to TC for white male participants, from a mean of 0.360 in the age group 5 to 9 to a mean of 0.211 in the age group 50 to 54. Thereafter the mean ratio increased slightly. In white women not using gonadal hormones the age-related decline in the ratio was only evident starting at the age group 35 to 39, from which it declines from 0.329 to 0.258 in the age group 55 to 59. White women using gonadal hormones showed very minor age-related changes in the HDL-C/TC ratio, varying around a mean of 0.300. The number of blacks examined was low and thus the racial comparisons must be interpreted with caution. For each gender, age-related trends were similar in black and white study participants. Black men, however, had a higher percentage of TC carried as HDL-C than white men in all age groups examined. Black women had a higher percentage of TC in HDL-C than white women only below age 20; in the adult age range no appreciable differences were seen. Pearson correlation coefficients between the lipid, lipoprotein, and lipoprotein ratios are presented. The ratio HDL-C/TC correlated highly with the ratio HDL-C/LDL-C (greater than 0.92 for all groups) and the former may be a more conveniently determined surrogate for the latter. Although not exhaustive regarding the information it conveys about a lipid pattern, the ratio HDL-C/TC has the advantage of summarizing complex associations into a single numerical approximation.
Incidental Diagnosis of Struma Ovarii Detected With 99mTc SPECT/CT
Authors: Mehmet Mulazimoglu, Muge Oner Tamam, Tevfik Ozpacaci, Duzgun Yildirim, Seyma Ekmekci, Deniz Ozcan, Senay Erdogan
Journal: Clinical Nuclear Medicine (2012)

We describe a case of asymptomatic struma ovarii in a 61-year-old woman who presented with elevated thyroglobulin level during checkup. Tc-99m pertechnetate whole-body scintigraphy showed a normal thyroid uptake, and an increased uptake localized on the upper left side of the urinary bladder corresponding to the ovary. Pelvic SPECT/CT confirmed increased uptake localized in left adnexal area. Histopatologic verification confirmed the diagnosis of struma ovarii. We report an unusual case of incidental diagnosis of struma ovarii with 99mTc pelvic SPECT/CT imaging.
High-Septal Pacing Reduces Ventricular Electrical Remodeling and Proarrhythmia in Chronic Atrioventricular Block Dogs
Authors: Stephan K.G. Winckels, Morten B. Thomsen, Peter Oosterhoff, Avram Oros, Jet D.M. Beekman, Nico J.M. Attevelt, Leo Kretzers, Marc A. Vos
Journal: Journal of the American College of Cardiology (2007)
Perspectives in cancer chemoprevention.
Authors: G D Stoner, M A Morse, G J Kelloff
Journal: Environmental Health Perspectives (1997)

Cancer chemoprevention can be defined as prevention of cancer by the administration of one or more chemical entities, either as individual drugs or as naturally occurring constituents of the diet. Based largely on the time period that chemopreventive agents exhibit activity in animal models of carcinogenesis, they can be classified as inhibitors of carcinogen formation, blocking agents, and suppressing agents. The majority of compounds that inhibit the formation of carcinogens prevent the formation of nitrosamines from secondary amines and nitrite in an acidic environment. Blocking agents are inhibitors of tumor initiation, while suppressing agents are inhibitors of tumor promotion/progression. Many well-characterized chemopreventive agents act at one or more steps in both tumor initiation and promotion/progression. The objective of this paper is to provide a general discussion of the mechanisms through which chemopreventive agents inhibit carcinogenesis. Examples of agents that act through these mechanisms are given; however, a complete listing of effective chemopreventive agents is not possible within the context of this paper. At the conclusion is a brief discussion of future prospects in cancer chemoprevention and obstacles to overcome.
Cardiac Tamponade During Anticoagulation
Authors: Lanie Belic
Journal: JAMA (1978)

ANTICOAGULATION producing a hemorrhagic cardiac tamponade in the presence of pericarditis is well documented.<sup>1-9</sup>Even though pericarditis is mentioned as a contraindication to anticoagulation, there is no alternative treatment when anticoagulation is clearly needed for a life-threatening situation. This report of a patient with phlegmasia cerulea dolens and hemopericardium illustrates this problem. <h3>Report of a Case</h3> A 49-year-old woman was referred because of roentgenographic evidence of interstitial lung changes associated with a two-month history of increasing dyspnea, a cough productive of scanty sputum, fatigue, generalized aches, anorexia, and a 4-kg weight loss. She had not experienced fever, chills, night sweats, or hemoptysis. She had smoked one to two packs of cigarettes a day for the past 15 years. There was no history of industrial exposure or exposure to noxious agents. Physical examination at the time of admission showed a blood pressure of 90/64 mm Hg, the pulse was 84
The spectrum of inflammatory skin disease following jejuno-ileal bypass for morbid obesity
Authors: CAMERON KENNEDY
Journal: British Journal of Dermatology (1981)

SUMMARY From a scries of 105 patients who had undergone jejuno-ileal bypass for morbid obesity, seven developed an episodic illness featuring inflammatory skin lesions, usually associated with a non destructive polyarthritis. Tenosynovitis, myalgia and fever had also occurred. The illness abated spontaneously in four patients. The most characteristic skin lesion was an erythematous macule which developed a central vesicle or pustule. Erythema nodosum-like lesions and liquefying nodules were also seen. Early lesions were characterised by a dense accumulation of neutrophils. Changes in dermal vessels were less destructive than is usually seen in immune complex mediated vasculitis. Circulating immune complexes could be demonstrated in patients actively developing skin lesions. They were also found in some patients long after activity had ceased and in jejuno-ileal bypass subjects who had never developed inflammatory lesions. Dapsone was effective in suppressing the skin and joint symptoms when metronidazole and/or tetracycline had failed.
Classical conditioning: The new hegemony
Authors: Jaylan Sheila Turkkan
Journal: Behavioral and Brain Sciences (1989)

Abstract Converging data from different disciplines are showing the role of classical conditioning processes in the elaboration of human and animal behavior to be larger than previously supposed. Restricted views of classically conditioned responses as merely secretory, reflexive, or emotional are giving way to a broader conception that includes problem-solving, and other rule-governed behavior thought to be the exclusive province of either operant conditiońing or cognitive psychology. These new views have been accompanied by changes in the way conditioning is conducted and evaluated. Data from a number of seemingly unrelated phenomena such as relapse to drug abuse by postaddicts, the placebo effect, and the immune response appear to involve classical conditioning processes. Classical conditioning, moreover, has been found to occur in simpler and simpler organisms and recently even demonstrated in brain slices and in utero. This target article will integrate the several research areas that have used the classical conditioning process as an explanatory model; it will challenge teleological interpretations of the classically conditioned CR and offer some basic principles for testing conditioning in diverse areas.
INTRACORONARY TRANSLUMINAL ATTENUATION GRADIENT IN 64-DETECTOR ROW CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY: A NOVEL METHOD OF CORONARY ARTERY DISEASE EVALUATION
Authors: Jin-Ho Choi, Young Bin Song, Joo-Yong Hahn, Seung Hyuk Choi, Hyeon-Cheol Gwon, YeonHyeon Choe, Jae K. Oh, Troy M. Labounty, Fay Y. Lin, James K. Min
Journal: Journal of the American College of Cardiology (2011)