tbuckley/cabot-search huggingface dataset:
Visualization of Suppressed Thyroid Tissue by Tc-99m MIBI
Authors: CHIA-HUNG KAO, WAN-YU LIN, SHYH-JEN WANG, SHIN-HWA YEH
Journal: Clinical Nuclear Medicine (1991)

The authors describe a case of suppressed normal thyroid tissue in a patient with autonomous toxic nodule, which was visualized by a Tc-99m MIBI thyroid scan without thyrotropin (TSH) stimulation. The findings suggest that Tc-99m MIBI can be a substitute for conventional thyroid imaging using I-131 to visualize suppressed normal thyroid tissue without TSH stimulation and its side effects.
Fates of Fe3O4 and Fe3O4@SiO2 nanoparticles in human mesenchymal stem cells assessed by synchrotron radiation-based techniques
Authors: Fei Tian, Guangcun Chen, Peiwei Yi, Jichao Zhang, Aiguo Li, Jing Zhang, Lirong Zheng, Zongwu Deng, Qin Shi, Rui Peng, Qiangbin Wang
Journal: Biomaterials (2014)
&lt;emph type="ital"&gt;A Woman Holding a Pink&lt;/emph&gt;
Authors: Thomas B. Cole
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interferons modulate FcɛRI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells
Authors: Trong Le, Jody Tversky, Kristin L. Chichester, Anja P. Bieneman, Shau-Ku Huang, Robert A. Wood, John T. Schroeder
Journal: Journal of Allergy and Clinical Immunology (2008)
Reporting of Effect Direction and Size in Abstracts of Systematic Reviews
Authors: E. M. Beller, P. P. Glasziou, S. Hopewell, D. G. Altman
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Transverse Myelitis as a Complication of Glandular Fever
Authors: P. B. Cotton, M. M. Webb-Peploe
Journal: BMJ (1966)

MEDICATL JOUNAL difference between the means of isomer III excretion (tg./24 hr.). DiscussionThe bone-marrow and the liver are the principal sites of the haem synthesis, though nearly every living cell is able to synthesize this chromogen.Numerous experimental and clinical investigations have indicated that the haem synthesis is affected in the bone-marrow by certain heavy metals and in the liver by some chemical substances and drugs (Goldberg and Rimington, 1962 ; Schmid, 1963).Impaired liver function is frequently observed after oral contraceptives (Eisalo et al., 1964(Eisalo et al., , 1965) ) and it is evident from the present work that they often also affect the porphyrin metabolism.The accurate mechanism which causes increased ALA excretion in healthy females taking oral contraceptives is not known and is a matter of speculation only.It may be easier to explain the increased proportion of coproporphyrin I in the urine.The urinary excretion of coproporphyrin I is distinctly increased in non-alcoholic cirrhosis, obstructive jaundice, and acute hepatitis.Intrahepatic cholestasis is the dominant factor causing partial transfer of type I coproporphyrin, normally excreted in the bile, to the blood and urine (Aziz et al., 1964).The increased proportion of coproporphyrin I in urine with a normal total urinary coproporphyrin excretion seen in our treated cases may be regarded as a sign of a relatively mild liver functional impairment.The observations of Eisalo et al. support the above assumption.Though the impairment in liver function is in most cases mild, it may in some cases be more severe.An example of this is Case 34 in our series.This patient developed cholestatic jaundice after taking an oral contraceptive for three months. SummaryUrinary excretion of 8-aminolaevulic acid, porphobilinogen, and coproporphyrin was studied in 22 healthy women of child- bearing age on oral contraceptives.The mean excretion of 8-aminolaevulic acid was significantly higher than the mean excretion in a control group of 21 women.There was no significant difference in the excretion of porphobilinogen in the two groups.Total coproporphyrin was normal in every case, but the study of isomer distribution in 15 cases revealed a higher mean isomer I content than normally.The possible mechanisms which cause these changes are discussed.
A Case of Haemorrhagic Measles
Authors: J. J. Linehan
Journal: BMJ (1942)

chemical inquiry.Such investigations, and mass biochemical observations, especially on children, will no doubt afford information which may be of use in post-war reconstruction.This war has still to be won by, for the most part, adults to whom the application of metabolic hypotheses is hardly of military value, as they must fight now under dietetic conditions largely imposed by the enemy.Finally, in this matter of vitamins as applied to the supply of man-power in a grave emergency here and in the U.S.A., it is out of perspective and unrealistic to spend time, money, and energy by labouring academic findings when at least the younger observers may get in touch with practical issues by looking further afield and seeing the real thing in greater mass as it exists in man under conditions of total war over-seas.
Elevated matrix metalloproteinase-2 and -3 production from human diabetic dermal fibroblasts
Authors: S.J. Wall, M.J. Sampson, N. Levell, G. Murphy
Journal: British Journal of Dermatology (2003)

Summary Background Diabetic foot ulcers are characterized by elevated levels of matrix metalloproteinases (MMP), which could lead to excessive matrix breakdown and disruption to healing. It is unknown if this elevation is a function of wound healing, or if it is present within normal skin and a primary contributor to the increased risk of impaired healing. Objectives To determine whether diabetic fibroblasts from unwounded skin show elevated MMP production compared with their nondiabetic counterparts. Patients and methods Circular skin biopsies (4 mm diameter) were taken from the inside upper arm of four controls without diabetes and from four subjects with insulin-treated diabetes. Fibroblasts were incubated for a further 72 h and conditioned medium was collected and stored at −20 °C. The conditioned medium was assessed by gelatin zymography and Western blotting for MMP-2 and MMP-3. Results Diabetic dermal fibroblasts showed significantly elevated production of MMP-2 (P < 0·05) and pro-MMP-3 (P < 0·05) when compared with their nondiabetic counterparts. Conclusions Dermal fibroblasts from normal unwounded skin are characterized by increased MMP production and this may be a primary contributing factor to the increased risk of nonhealing foot ulceration in diabetes.
Environmental threats to children's health in Southeast Asia and the Western Pacific.
Authors: William A Suk, Kuhnying Mathuros Ruchirawat, Kalpana Balakrishnan, Martha Berger, David Carpenter, Terri Damstra, Jenny Pronczuk de Garbino, David Koh, Philip J Landrigan, Irma Makalinao, Peter D Sly, Y Xu, B S Zheng
Journal: Environmental Health Perspectives (2003)

The Southeast Asia and Western Pacific regions contain half of the world's children and are among the most rapidly industrializing regions of the globe. Environmental threats to children's health are widespread and are multiplying as nations in the area undergo industrial development and pass through the epidemiologic transition. These environmental hazards range from traditional threats such as bacterial contamination of drinking water and wood smoke in poorly ventilated dwellings to more recently introduced chemical threats such as asbestos construction materials; arsenic in groundwater; methyl isocyanate in Bhopal, India; untreated manufacturing wastes released to landfills; chlorinated hydrocarbon and organophosphorous pesticides; and atmospheric lead emissions from the combustion of leaded gasoline. To address these problems, pediatricians, environmental health scientists, and public health workers throughout Southeast Asia and the Western Pacific have begun to build local and national research and prevention programs in children's environmental health. Successes have been achieved as a result of these efforts: A cost-effective system for producing safe drinking water at the village level has been devised in India; many nations have launched aggressive antismoking campaigns; and Thailand, the Philippines, India, and Pakistan have all begun to reduce their use of lead in gasoline, with resultant declines in children's blood lead levels. The International Conference on Environmental Threats to the Health of Children, held in Bangkok, Thailand, in March 2002, brought together more than 300 representatives from 35 countries and organizations to increase awareness on environmental health hazards affecting children in these regions and throughout the world. The conference, a direct result of the Environmental Threats to the Health of Children meeting held in Manila in April 2000, provided participants with the latest scientific data on children's vulnerability to environmental hazards and models for future policy and public health discussions on ways to improve children's health. The Bangkok Statement, a pledge resulting from the conference proceedings, is an important first step in creating a global alliance committed to developing active and innovative national and international networks to promote and protect children's environmental health.
GSK backs campaign for disclosure of trial data
Authors: Z. Kmietowicz
Journal: BMJ (2013)

The UK based pharmaceutical giant GlaxoSmithKline has become the first drug company to sign up to a campaign for all clinical trials to be registered and their full results disclosed.

The AllTrials initiative (alltrials.net) was set up in January by the charity Sense About Science, the BMJ , and other supporters of transparency in research.1 It is calling for registration of all clinical trials and for full study results and full clinical study reports (CSRs) to be made publicly available. 

CSRs are formal study reports that provide more details on the design, methods, and results of clinical trials than published papers and …
Can dog allergen alone, if combined with indoor pollution, be responsible for asthma in children?
Authors: C. Carlsten, M. Chan-Yeung, M. Brauer
Journal: European Respiratory Journal (2011)

From the authors:

We thank G. Liccardi and co-workers for their interest in our work. In our article [1], we recognised the potentially important role of endotoxin. Furthermore, we agree that allergenic exposures other …
Transforming growth factor beta in normal human lung: preferential location in bronchial epithelial cells.
Authors: A Magnan, I Frachon, B Rain, M Peuchmaur, G Monti, B Lenot, M Fattal, G Simonneau, P Galanaud, D Emilie
Journal: Thorax (1994)

Transforming growth factor beta (TGF-beta) is an immunomodulatory cytokine regulating the proliferation and differentiation of various cell types. It also contributes to the maintenance of tissue architecture by influencing the production of extracellular matrix components. TGF-beta has been detected in bronchoalveolar lavage fluid from normal human lung, but the nature and distribution of cells containing TGF-beta in this organ remain unknown.Fourteen normal human lung specimens were studied by immunohistochemistry with a monoclonal antibody recognizing TGF-beta 1, TGF-beta 2 and TGF-beta 3.TGF-beta was detected in all cases. Bronchial epithelial cells contained the largest amounts of TGF-beta. In these cells the staining was brightest at the apical pole. Macrophages and smooth muscle cells also contained TGF-beta, although less than epithelial cells. No TGF-beta was detected in other cell populations, including endothelial cells, fibroblasts, and pneumocytes.The bronchial epithelial compartment appears to be the main location of TGF-beta in the normal human lung, suggesting that this cytokine has a pivotal role in the immunological properties of the bronchial mucosa.
Increased ileal-mucosal-arterial PCO2 gap is associated with impaired villus microcirculation in endotoxic pigs
Authors: I.F. Tugtekin, P. Radermacher, M. Theisen, M. Matejovic, A. Stehr, F. Ploner, K. Matura, C. Ince, M. Georgieff, K. Träger
Journal: Intensive Care Medicine (2001)
Interferon-γ and the Interferon-Inducible Chemokine CXCL10 Protect Against Aneurysm Formation and Rupture
Authors: Victoria L. King, Alexander Y. Lin, Fjoralba Kristo, Thomas J.T. Anderson, Neil Ahluwalia, Gregory J. Hardy, A. Phillip Owens, Deborah A. Howatt, Dongxiao Shen, Andrew M. Tager, Andrew D. Luster, Alan Daugherty, Robert E. Gerszten
Journal: Circulation (2009)

Background— Vascular disease can manifest as stenotic plaques or ectatic aneurysms, although the mechanisms culminating in these divergent disease manifestations remain poorly understood. T-helper type 1 cytokines, including interferon-γ and CXCL10, have been strongly implicated in atherosclerotic plaque development. Methods and Results— Here, we specifically examined their role in the formation of abdominal aortic aneurysms in the angiotensin II–induced murine model. Unexpectedly, we found increased suprarenal aortic diameters, abdominal aortic aneurysm incidence, and aneurysmal death in apolipoprotein E– and interferon-γ–deficient ( Apoe −/− /Ifng −/− ) mice compared with Apoe −/− controls, although atherosclerotic luminal plaque formation was attenuated. The interferon-γ–inducible T-cell chemoattractant CXCL10 was highly induced by angiotensin II infusion in Apoe −/− mice, but this induction was markedly attenuated in Apoe −/− /Ifng −/− mice. Apoe −/− /Cxcl10 −/− mice had decreased luminal plaque but also increased aortic size, worse morphological grades of aneurysms, and a higher incidence of death due to aortic rupture than Apoe −/− controls. Furthermore, abdominal aortic aneurysms in Apoe −/− /Cxcl10 −/− mice were enriched for non–T-helper type 1–related signals, including transforming growth factor-β1. Treatment of Apoe −/− /Cxcl10 −/− mice with anti-transforming growth factor-β neutralizing antibody diminished angiotensin II–induced aortic dilation. Conclusions— The present study defines a novel pathway in which interferon-γ and its effector, CXCL10, contribute to divergent pathways in abdominal aortic aneurysm versus plaque formation, inhibiting the former pathology but promoting the latter. Thus, efforts to develop antiinflammatory strategies for atherosclerosis must carefully consider potential effects on all manifestations of vascular disease.
ADVANCES IN MANAGEMENT OF THE NEPHROTIC STATE
Authors: John A. Luetscher
Journal: JAMA (1953)

The nephrotic state is a well-defined clinical entity without a generally accepted name. Nephrosis, lipemic or lipoid nephrosis, the nephrotic syndrome, and other names carry with them certain implications of etiology, pathology, or prognosis that are not justified in the present state of our very limited knowledge. For simplicity, the term nephrosis will be used to designate the syndrome of proteinuria, low serum albumin, high blood lipids, and variable edema. Forty-two patients, who have been studied and treated during the past three years, form the basis of the present report. One-half of the patients were 1 to 5 years old at the onset of edema. The age of the other patients varied evenly from 6 to 50 years. No effort was made to classify patients according to cause (glomerular nephritis or lipoid nephrosis). Although a respiratory infection often preceded the onset of nephrosis, the signs of acute glomerular nephritis were
Uroporphyria in Hfe mutant mice given 5-aminolevulinate: A new model of Fe-mediated porphyria cutanea tarda
Authors: Peter R. Sinclair, Nadia Gorman, Heidi S. Walton, William J. Bement, Jacqueline F. Sinclair, Glenn S. Gerhard, Juliana G. Szakacs, Nancy C. Andrews, Joanne E. Levy
Journal: Hepatology (2001)

Porphyria cutanea tarda (PCT), a liver disease with skin lesions caused by excess liver production of uroporphyrin (URO), is associated with consumption of alcoholic beverages or estrogens, and moderate iron overload. Recently, it has been shown that many PCT patients carry mutations in the HFE gene, which is responsible for hereditary hemochromatosis. Mice homozygous for either the null mutation in the Hfe gene or the C282Y missense mutation rapidly accumulate hepatic parenchymal iron similar to patients with hemochromatosis. Here we investigated whether disruption of the murine Hfe gene would result in hepatic uroporphyria. Mice homozygous for the Hfe-null mutation accumulated high levels of hepatic URO when fed 5-aminolevulinate (ALA). Hfe (+/-) mice also accumulated hepatic URO when fed ALA, but at a much slower rate. The amount of accumulated URO in the null mutant mice was similar to that in wild-type mice treated with iron carbonyl in the diet, or injected with iron dextran. Iron in both wild-type and Hfe (+/-) mice was mostly in Kupffer cells. In contrast, Hfe (-/-) mice had considerable parenchymal iron deposition as well, in a pattern similar to that observed in wild-type mice treated with iron carbonyl. URO accumulation was accompanied by 84% and 33% decreases in hepatic uroporphyrinogen decarboxylase activities in Hfe (-/-) and Hfe (+/-) mice, respectively. No increases in CYP1A2 or other cytochrome P450s were detected in the Hfe-null mutant mice. We conclude that this experimental model of uroporphyria is a valid model for further investigations into the mechanism of PCT.
SPECIFIC POSITIVE SELECTION OF LYMPHOCYTES REACTIVE TO STRONG HISTOCOMPATIBILITY ANTIGENS
Authors: Jonathan C. Howard, Darcy B. Wilson
Journal: The Journal of Experimental Medicine (1974)

Selected populations of thymus-derived (T) rat lymphocytes having specific immunological reactivity to chosen histocompatibility (H) alloantigens are found among the cellular products of the mixed lymphocyte interaction (MLI). Such specific selection seems to depend on (a) the antigen-induced proliferation of specific H antigen reactive cells (HARC), and (b) the disappearance of nonreactive cells from the cultures. When the surviving cells from this lymphocyte-antigen interaction are transferred into thymectomized, X-irradiated, marrow-reconstituted syngeneic recipients (B rats) which lack detectable T-lymphocyte functions, the lymphocyte populations subsequently recovered from the hosts possess the capacity to react in the MLI and in the graft-vs.-host (GVH) reaction, and the reactions have specificity for the original priming alloantigens. In addition, these findings identify the cell that reacts in the MLI with the GVH reactive cell.
Protective protein gene mutations in galactosialidosis.
Authors: M Shimmoto, Y Fukuhara, K Itoh, A Oshima, H Sakuraba, Y Suzuki
Journal: Journal of Clinical Investigation (1993)

Four different protective protein cDNA mutations, 146A-->G (Q49R), 193T-->C (W65R), 268-269TC-->CT (S90L), and 1184A-->G (Y395C), were identified in six Japanese galactosialidosis patients with various phenotypic manifestations, and another mutation, 746T-->A (Y249N), in a patient of French-German origin with an atypical clinical course. Y395C was a common mutation in four Japanese patients in infancy and childhood; two juvenile patients were compound heterozygotes of Y395C and another common mutation, SpDEx7, and the other two infants were compound heterozygotes of Y395C and mutant alleles other than SpDEx7. We confirmed these mutations in genomic DNA by direct-sequence analysis or restriction-site analysis. The mutant cDNA clones, transiently expressed in a transformed galactosialidosis cell line, did not restore the secondarily deficient beta-galactosidase or alpha-neuraminidase activity except for the Y249N mutation that expressed some carboxypeptidase activity and restored the two lysosomal enzyme activities. Pulse-chase analysis detected a small amount of the mature form, as well as the precursor, in the cells transfected with the Y249N cDNA. Only precursor proteins were detected, mature proteins not appearing for the other mutant cDNAs.
Gastric neuroendocrine tumor with extensive ossification
Authors: D. Del Pozo Prieto, M. Vélez, L. Espinosa, P. González de Canales, I. Moral, M. Villafruela
Journal: Endoscopy (2012)

A 40-year-old man underwent endoscopic ultrasound (EUS) because of suspected submucosal gastric tumor diagnosed after an episode of severe bleeding ([Fig. 1]). EUS revealed a well-delineated, 18-mm hypoechogenic lesion in the submucosa with a calcified area inside it ([Fig. 2], [Video 1]). Three lymph nodes near the celiac trunk showed the same characteristics of the gastric lesion: well-delineated and hypoechogenic, with central calcification ([Fig. 3], [Video 1]). A fine-needle aspiration (FNA) biopsy of the largest lymph node (14 mm) was carried out using a 22-G needle, and histological examination revealed reactive lymphadenitis.