tbuckley/cabot-search huggingface dataset:
Contrast media. Myeloma protein precipitates in urography
Authors: E. C. Lasser
Journal: JAMA (1966)

IN 1939, Holman<sup>1</sup>described a patient with multiple myeloma in whom renal failure developed following pyelography. It is not clear from this report whether the pyelography was of the retrograde or intravenous type, and renal failure did not occur until 8 to 12 days after the contrast study. While this case does not represent a bona fide instance of renal failure in multiple myeloma consequent to pyelography, it nevertheless alerted subsequent observers to the potential hazards of these procedures in such patients. What appears to be the first genuine case of acute renal failure following intravenous pyelography in a patient with myelomatosis was recorded by Bartels et al<sup>2</sup>in 1954. The contrast material utilized here was iodopyracet (Diodrast). Since that time, 14 additional cases have been recorded.<sup>3-11</sup>Of the 15 cases cited, 13 had intravenous pyelography and 2 had retrograde pyelography. Eight studies were carried out with
Mechanical Ventilation Techniques
Authors: Ernest W. Johnson
Journal: JAMA (1975)

<h3>To the Editor.—</h3> After reading the article entitled "Intensive Respiratory Care Unit: Review of Ten Years' Experience" (233:34, 1975), I got the impression that the authors were unfamiliar with mechanical ventilation techniques other than those via a tracheostomy or an endotracheal tube. There are a number of ways of enabling individuals to breathe without compromising the trachea, and I think it would have been important to include these other techniques. For example, the tank respirator, the chest-abdomen cuirass, the pneumobelt, positive pressure by mouth, and the rocking bed are available today and should be used as alternatives to a tracheostomy tube or positive-pressure or volume ventilators. The complications of artificial ventilation by endotracheal tube or tracheostomies were not mentioned. They include tracheoesophageal fistula, tracheostenosis, and erosion of the tracheal tube into the innominate artery. All of these complications are reported in the literature and should be considered when mechanical respiration
TCT-241 Two-Year Clinical Outcome of Patients With Implantation of Second-Generation Drug-Eluting Stents in the Right Coronary Ostium in the TWENTE Trial
Authors: Ming Kai Lam, Hanim Sen, Gert van Houwelingen, Marlies M. Kok, Kenneth Tandjung, Marije M. Löwik, Mounir W. Basalus, Janne C. Mewes, Martin G. Stoel, Gerard C. Linssen, Carine J. Doggen, Maarten J. Ijzerman, Clemens von Birgelen
Journal: Journal of the American College of Cardiology (2014)
INDUSTRIAL HEALTH UNDER NON-MEDICAL SUPERVISION
Authors: EMERY R. HAYHURST
Journal: JAMA (1925)

The time at my disposal forces me to be somewhat brief and dogmatic. Dr. William H. Park<sup>1</sup>commented last year before the Conference of Physicians in Industry on the changing types of diseases from the strictly communicable diseases, pronounced in childhood and young adult life, to the diseases of industry and civilization. My discussion is limited to the industrial aspects, and then in only a small way. <h3>THE STATUS QUO</h3> I think we can all agree pretty well with Selby<sup>2</sup>that the recent war made industrial hygiene prominent in this country, and that now<i>the physician in well organized plants</i>has come into his own and is governing his bailiwick himself instead of his employer, or the feeble attempts of official departments of government. But with this exception, in practically all states, medical inspection of the hygiene of working conditions is rare indeed, so that industrial hygiene is
Is there any relationship between IEL and lymphoid follicles in the gastric mucosa? Reply
Authors: G CAMMAROTA
Journal: Gut (2000)

Editor,—The article by Hayat et al ((1999) Gut 45:495–498; [OpenUrl][1][PubMed][2]) reporting the decrease in intraepithelial lymphocytes (IEL) in the gastric mucosa after Helicobacter pylori eradication is interesting and confirms the suggestion that lymphocytic gastritis could be a manifestation of an atypical host immune response to H pylori . But we would like to ask Dr Hayat and colleagues whether they also investigated the presence of lymphoid follicles in the lamina propria of gastric mucosa of their patients. In fact, mucosa associated lymphoid tissue (MALT), organised in follicles with a germinative centre and B cell reactivity, which structurally resemble Peyer's patches, can develop in the lamina propria after H pylori infection.1 ,2 Also, the development of these reactive lymphoid follicles may depend on the characteristics of the host and stimuli other than H pylori . We found lymphoid follicles in the gastric mucosa of 30% of our coeliac patients, of whom only 38% were … [1]: {openurl}?query=rft.jtitle%253DJournal%2Bof%2Bclinical%2Bgastroenterology%26rft.stitle%253DJ%2BClin%2BGastroenterol%26rft.aulast%253DCammarota%26rft.auinit1%253DG.%26rft.volume%253D21%26rft.issue%253D2%26rft.spage%253D118%26rft.epage%253D122%26rft.atitle%253DPrevention%2Band%2Btreatment%2Bof%2Blow-grade%2BB-cell%2Bprimary%2Bgastric%2Blymphoma%2Bby%2Banti-H.%2Bpylori%2Btherapy.%26rft_id%253Dinfo%253Apmid%252F8583076%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=8583076&link_type=MED&atom=%2Fgutjnl%2F47%2F2%2F314.atom
Maternal mortality is a human rights issue, delegates insist
Authors: Jacqui Wise
Journal: BMJ (2007)

Maternal mortality must be recognised as a human rights issue, demanded delegates at the Women Deliver conference in London last week.

A new international initiative on maternal mortality and human rights—a collaboration of organisations advocating safe motherhood and human rights—was launched at the conference to focus attention on women and their human right to safe pregnancy and childbirth.

“The scale of avoidable maternal mortality is a human rights catastrophe,” said Lynn Freedman, director of the averting maternal death and disability programme at Columbia University's Mailman School of Public Health, which is behind the initiative. 

She said, “There are over 500 000 maternal deaths worldwide each year that are largely avoidable. In most cases these amount to violations of women's rights to life, health, non-discrimination, and equality.” 

At the conference, …
Current problems and future challenges in randomized clinical trials.
Authors: A R Feinstein
Journal: Circulation (1984)

AS HISTORIANS review the advances of therapeutic science in the second half of the 20th century, one of the outstanding methodologic achievements will sure- ly be the use of evidence from randomized trials to show the efficacy of new therapeutic agents.With this type of evidence, clinicians and patients can now be reasonably reassured, for the first time in medical history, that a new treatment actually does what is claimed for it.Scientific problems in comparing therapy.Although the concept of randomized assignment was developed in the 20th century, the idea of controlled comparisons of therapy dates back to antiquity.A comparative trial of two diets was reported in the Book of Daniel'; citrus fruits were compared with five other agents when James Lind2 treated scurvy in 1747; early and late bloodletting were contrasted in 1835 by Pierre Louis;3 and many of the new therapeutic agents introduced in the first half of the 20th century received documented comparison with older agents.'7The comparisons, however, usually had four fea- tures that were scientifically unattractive.One obvious problem was that the comparisons were often noncon- current.Although the results would be presented as a contrast of newer treatment vs older treatment, the newer treitment was often given in a newer era to patients identified with newer diagnostic methods and
Acquired inhibitor to human factor VIII associated with paraproteinaemia and subsequent development of chronic lymphatic leukaemia.
Authors: P R Kelsey, M J Leyland
Journal: BMJ (1982)

The initial gastrointestinal illness with bloody stools suggested a Campylobacter infection; this was confirmed by the high antibody titre and by stool culture, which grew a Campylobacter species at high temperatures to identify it as one of the C colilC jejuni group.The subsequent neurological illness was consistent with a clinical diagnosis of the Guillain-Barre syndrome.'Though this syndrome may follow a gastrointestinal illnessl 2 an organism is rarely isolated from the stools, though a Salmonella species was found in two cases.3Sixteen cases of Guillain-Barre syndrome occurred after an outbreak of water pollution, in which 5000 people had diarrhoea but no definite causative organism was found.5So far as we are aware no case has been reported after Campylobacter infection.In our patient the Guillain-Barre syndrome occurred two weeks after the initial infection.This interval is similar to that seen after other gastrointestinal illnesses and suggests that the Guillain-Barre syndrome was triggered by the infection.There is no report of this syndrome occurring with any of the drugs he had re- ceived.Since Campylobacter infections have been recognised only in recent years, and the organism may be difficult to isolate from the stools, previous cases of Campylobacter infection associated with the Guillain-Barre syndrome may have been missed.Serum antibody titres to Campylobacter may help to resolve this in future cases of the Guillain-Barre syndrome associated with a gastrointestinal illness.
Mouth-to-Nose Resuscitation During Convulsive Seizures
Authors: James O. Elam
Journal: JAMA (1961)

Severe seizures occurring during electroconvulsive therapy challenge any method of respiratory resuscitation. In 12 adults undergoing this treatment, mouth-to-nose breathing was consistently successful in preventing cyanosis. Higher than customary pressures were needed, and sometimes they had to be maintained long enough to overcome intermittent closure of the glottis, but the technique was easy to learn. The authors recommend mouth-to-nose breathing for emergencies in any patient who is in danger of anoxia during convulsions.
Cutaneous manifestations of adult T cell leukemia/lymphoma
Authors: Heng-Leong Chan, Ih-Jen Su, Tseng-tong Kuo, Yue-Zon Kuan, Ming-jing Chen, Lee-Yung Shih, Tadaaki Eimoto, Yoshiaki Maeda, Masahiro Kikuchi, Morishige Takeshita
Journal: Journal of the American Academy of Dermatology (1985)
Viral Hepatitis and Delta Infection. Edited by Giorgio Verme, Ferruccio Bonino, and Mario Rizzetto. (Proceedings of an International Symposium on Viral Hepatitis June 10-11, 1983, Torino, Italy), xviii + 421 pp. New York: Alan R. Liss, 1984. $54.00.
Authors: Charles S. Davidson, Raymond S. Koff
Journal: Hepatology (1984)
Role of CEA—A Challenge of a Verdict-Reply
Authors: Charles G. Moertel
Journal: JAMA (1978)

Drs Mavligit and McMurtrey have accurately represented our conclusion that the CEA test is insensitive for early detection of recurrence of colorectal carcinoma, as it is for early detection of primary carcinoma. They do not, however, present any convincing evidence to challenge this verdict. They are correct in their conclusion that we ignored the two publications they quote. In one of these, only two cases of pelvic recurrence were cited, and in the other, only five. We do not think that relevant observations regarding incidence can be made from population bases that can be counted on the fingers of one hand. We are pleased they agree that an adequate history and physical examination should supercede the CEA test in detecting pelvic recurrence of colorectal carcinoma. In our opinion the same conclusion should pertain in detecting recurrence elsewhere.  It is most disturbing that Drs Mavligit and McMurtrey have implied
Organic Polymers: Photostimulation of Whole‐Cell Conductance in Primary Rat Neocortical Astrocytes Mediated by Organic Semiconducting Thin Films (Adv. Healthcare Mater. 3/2014)
Authors: Valentina Benfenati, Nicola Martino, Maria Rosa Antognazza, Assunta Pistone, Stefano Toffanin, Stefano Ferroni, Guglielmo Lanzani, Michele Muccini
Journal: Advanced Healthcare Materials (2014)

On page 392, Valentina Benfenati, Maria Rosa Antognazza, Michele Muccini, and colleagues show how the photostimulation of a semiconducting polymer blend modulates the ion channel conductance of astrocytes cultured on top of the device. The device can be used as a selective tool to study ion channel conductances in non-excitable cells.
Gastric Stapling for Morbid Obesity
Authors: Robert W. Ikard
Journal: JAMA (1979)

To the Editor.—  Proximal   described by William Pace, MD (240:1941, 1978), is a relatively simple surgical approach to the problem of morbid obesity. The term gastric stapling for this innovative procedure seems inprecise and inadequate. I would suggest the term gastric partition.  Though its ultimate efficacy is unknown, the procedure will doubtless be employed on a widespread basis. Uniform nomenclature will be necessary for efficient communication. Gastric partition seems most accurate in this regard.
LACK OF ASSOCIATION BETWEEN ON–TREATMENT PLATELET REACTIVITY AND ISCHEMIC OUTCOMES IN DIABETIC PATIENTS: ONE YEAR RESULTS OF THE ADAPT–DES STUDY
Authors: Thomas D. Stuckey, Ajay Kirtane, Ke Xu, Bernhard Witzenbichler, Giora Weisz, Michael Rinaldi, Franz–Josef Neumann, Chris Metzger, Timothy Henry, David Cox, Peter Duffy, Bruce Brodie, Ernest Mazzaferri, Ecaterina Cristea, Helen Parise, Roxana Mehran, Gregg Stone
Journal: Journal of the American College of Cardiology (2013)
Physician Responsibility in the Nuclear Age
Authors: Bernard Lown
Journal: JAMA (1995)

"THE WORLD is moving inexorably toward the use of nuclear weapons."<sup>1</sup>These ominous words, spoken in 1981, were a clarion call for a new world organization, the International Physicians for the Prevention of Nuclear War (IPPNW). The nuclear arms race was then about to swing into high gear, though nuclear armories were already burgeoning with enough megatonnage to destroy life on earth many times over. Before the decade was out, nuclear stockpiles equaled in their destructiveness 1 million Hiroshimas. Never before had humankind possessed the power to make this planet uninhabitable. Rapidly advancing weapons technology increased the danger by spawning illusions of achieving nuclear superiority and even of the possibility of victory. In the mad calculus of the day, hope for survival was based on striking first and thereby gaining advantage by reducing an enemy's siloed missiles. Weapons were therefore poised at hair-trigger readiness for a preemptive first strike.
Video‐mosaicing of reflectance confocal images for examination of extended areas of skin <i>in vivo</i>
Authors: K. Kose, M. Cordova, M. Duffy, E.S. Flores, D.H. Brooks, M. Rajadhyaksha
Journal: British Journal of Dermatology (2014)

Journal Article Video‐mosaicing of reflectance confocal images for examination of extended areas of skin in vivo Get access K. Kose, K. Kose Dermatology Service Memorial Sloan Kettering Cancer Center New York NY U.S.A Search for other works by this author on: Oxford Academic Google Scholar M. Cordova, M. Cordova Dermatology Service Memorial Sloan Kettering Cancer Center New York NY U.S.A Search for other works by this author on: Oxford Academic Google Scholar M. Duffy, M. Duffy Department of Biomedical Engineering King's College London U.K Search for other works by this author on: Oxford Academic Google Scholar E.S. Flores, E.S. Flores Dermatology Service Memorial Sloan Kettering Cancer Center New York NY U.S.A Search for other works by this author on: Oxford Academic Google Scholar D.H. Brooks, D.H. Brooks Dermatology Service Memorial Sloan Kettering Cancer Center New York NY U.S.ADepartment of Electrical and Computer Engineering Northeastern University Boston MA U.S.A Search for other works by this author on: Oxford Academic Google Scholar M. Rajadhyaksha M. Rajadhyaksha Dermatology Service Memorial Sloan Kettering Cancer Center New York NY U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 5, 1 November 2014, Pages 1239–1241, https://doi.org/10.1111/bjd.13050 Published: 01 November 2014
The Antioxidant Acetylcysteine Reduces Cardiovascular Events in Patients With End-Stage Renal Failure
Authors: Martin Tepel, Markus van der Giet, Mario Statz, Joachim Jankowski, Walter Zidek
Journal: Circulation (2003)

Background— Patients with end-stage renal failure have increased oxidative stress and show elevated cardiovascular mortality. Whether increased cardiovascular events can be prevented by the administration of antioxidants is unknown. Methods and Results— We evaluated the effects of acetylcysteine, a thiol-containing antioxidant, on cardiovascular events in patients undergoing hemodialysis. A prospective, randomized, placebo-controlled trial was conducted between October 1, 1999, and September 30, 2001, in 134 patients (76 male and 58 female) with a mean age of 62±16 years (mean±SD) who had been undergoing maintenance hemodialysis for a minimum of 3 months 3 times weekly in an ambulatory center. Median (range) follow-up was 14.5 (1 to 24) months. Patients were randomly assigned either to receive acetylcysteine (600 mg BID) or placebo. The primary end point was a composite variable consisting of cardiac events including fatal and nonfatal myocardial infarction, cardiovascular disease death, need for coronary angioplasty or coronary bypass surgery, ischemic stroke, peripheral vascular disease with amputation, or need for angioplasty. Secondary end points included each of the component outcomes, total mortality, and cardiovascular mortality. A total of 18 (28%) of the 64 hemodialysis patients assigned to acetylcysteine group and 33 (47%) of the 70 hemodialysis patients assigned to control group had a primary end point (relative risk, 0.60 [95% CI, 0.38 to 0.95], P =0.03). No significant differences in secondary end points or total mortality were detected. Conclusions— In hemodialysis patients, treatment with acetylcysteine (600 mg BID) reduces composite cardiovascular end points.
Experimental Treatment of Poisoning Due to Ethylene Glycol and Halogenated Ethanols.
Authors: John E. Peterson
Journal: Annals of Internal Medicine (1964)

s1 October 1964Experimental Treatment of Poisoning Due to Ethylene Glycol and Halogenated Ethanols.John E. Peterson, M.D., F.A.C.P., D. I. Peterson, M.D., M. G. Hardinge, M.D., W. E. C. Wacker, M.D.John E. Peterson, M.D., F.A.C.P.Search for more papers by this author, D. I. Peterson, M.D.Search for more papers by this author, M. G. Hardinge, M.D.Search for more papers by this author, W. E. C. Wacker, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-813_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTreatment with ethanol protects rats and monkeys from certain lethal effects of ethylene glycol that are attributed to products of enzymatic oxidation rather than to the glycol itself. In treated rats, the LD50 for ethylene glycol is almost doubled. Five squirrel monkeys protected with ethanol survived a lethal dose of ethylene glycol while five other monkeys receiving similar amounts of glycol and having no subsequent treatment with ethanol died.Oxidation of ethylene glycgol is catalyzed by LADH, and catalysis is inhibited by ethanol, which has a high catalytic constant. When treated with ethanol, animals appear to oxidize ethylene glycol more... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John E. Peterson, M.D., F.A.C.P.; D. I. Peterson, M.D.; M. G. Hardinge, M.D.; W. E. C. Wacker, M.D.Affiliations: Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 813-813KeywordsEthanolEthyleneLethal doseMedian lethal dose ePublished: 1 December 2008 Issue Published: 1 October 1964 PDF downloadLoading ...
A Statewide Medicaid Enhanced Prenatal Care Program
Authors: LeeAnne Roman, Jennifer E. Raffo, Qi Zhu, Cristian I. Meghea
Journal: JAMA Pediatrics (2014)

Policy makers and practitioners need rigorous evaluations of state-based Medicaid enhanced prenatal care programs that provide home visiting to guide improvements and inform future investments. Effects on adverse birth outcomes are of particular interest.To test if participation in the Michigan statewide enhanced prenatal care program, the Maternal Infant Health Program (MIHP), accounting for program timing and dosage, reduced risk for low birth weight (LBW) and preterm birth, particularly among black women who are at greater risk for adverse outcomes.Quasi-experimental cohort study. Data, including birth records, Medicaid claims, and monthly program participation, were extracted from the Michigan Department of Community Health warehouse. Participants included all 60 653 pregnant women who had a Medicaid-insured singleton birth between January 1 and December 31, 2010, in Michigan. The MIHP participants were propensity score-matched with nonparticipants based on demographics, previous pregnancies, socioeconomic status, and chronic disease.An enhanced prenatal care program.Low birth weight, very low birth weight (VLBW), preterm birth, and very preterm birth.In the propensity score-matched models, black women who enrolled and were screened in the MIHP by the end of the second trimester had lower odds of VLBW (odds ratio [OR], 0.76; 95% CI, 0.59-0.97) and very preterm births (OR, 0.68; 95% CI, 0.54-0.85) than matched nonparticipants. Black MIHP participants who enrolled and were screened in the program by the second trimester and had at least 3 additional prenatal MIHP contacts had lower odds of LBW (OR, 0.76; 95% CI, 0.65-0.89), VLBW (0.42; 0.30-0.61), preterm birth (0.71; 0.61-0.83), and very preterm birth (0.41; 0.30-0.57) compared with matched nonparticipants. The MIHP participants of other races and ethnicities who enrolled and were screened in the program by the second trimester and had at least 3 additional prenatal MIHP contacts had lower odds of LBW (OR, 0.78; 95% CI, 0.66-0.93), VLBW (0.38; 0.22-0.66), preterm birth (0.77; 0.66-0.89), and very preterm birth (0.63; 0.43-0.91) compared with matched nonparticipants.Participation in MIHP reduced the risk for adverse birth outcomes in a diverse, disadvantaged population. The study adds to the evidence base for enhanced prenatal care home visiting programs and informs state and federal investments.