tbuckley/cabot-search huggingface dataset:
CORONARY BLOOD FLOW ASSESSMENT AFTER SUCCESSFUL REPERFUSION FOR ACUTE MYOCARDIAL INFARCTION PREDICTS THE RISK OF IN-HOSPITAL AND LONG-TERM MALIGNANT ARRHYTHMIA
Authors: Kitae Kim, Atsushi Yamamuro, Satoshi Honda, Tomohiro Nishino, Shunsuke Funakoshi, Noriyuki Kimura, Yoshimori An, Takeshi Kitai, Atsushi Kobori, Natsuhiko Ehara, Makoto Kinoshita, Shuichiro Kaji, Tomoko Tani, Shigefumi Morioka, Toru Kita, Yutaka Furukawa
Journal: Journal of the American College of Cardiology (2010)
Measurement by fluorescence of interstitial adenosine levels in normoxic, hypoxic, and ischemic perfused rat hearts.
Authors: R A Fenton, J G Dobson
Journal: Circulation Research (1987)

An improved assay was used to investigate the effects of hypoxia or ischemia on interstitial fluid and coronary venous effluent levels of adenosine in isolated perfused nonworking rat hearts. The adenosine in 5- to 10-microliter samples of left ventricular epicardial surface transudates and coronary effluents was reacted with chloroacetaldehyde, and the fluorescent derivative (1,N6-ethenoadenosine) was quantitated using high pressure liquid chromatography and fluorescence detection. Hearts responding to hypoxia could be separated into two groups. In one group of hearts, the control (normoxic) transudate and effluent adenosine concentrations were 94 +/- 24 and 41 +/- 6 pmol/ml, respectively. These values increased by 118 and 96%, respectively, with 5 minutes of hypoxia (30% O2), and returned to control levels 5 minutes after resumption of normoxia. In a second group of hearts, the normoxic control levels of adenosine in the transudates (42 +/- 7 pmol/ml) and coronary effluents (62 +/- 17 pmol/ml) were increased with hypoxia by 174 and 1,178%, respectively. However, the transudate levels continued to rise for 5 minutes after resumption of normoxic perfusion while effluent levels fell. In another series of hearts, global ischemia for 30 seconds elicited an elevation of transudate adenosine levels by 362 to 641% above control (58 +/- 15 pmol/ml) as determined 30 seconds after resumption of perfusion flow.(ABSTRACT TRUNCATED AT 250 WORDS)
Chronic Meningitis in Weil's Disease
Authors: F. Murgatroyd
Journal: BMJ (1937)

Background/Aim: The aim of this study was to reveal risk factors for lung injury following irinotecan administration for the treatment of neoplasms. Patients and Methods: This study included 204 patients who received irinotecan from October 2005 to November 2014 and had evaluable chest CT images before initiation of irinotecan. Results: Six (2.9%) patients developed lung injury and, of these, 2 had preexisting interstitial lung disease (pre-ILD). The frequency of lung injury in patients with pre-ILD was 11% (2 of 19) while that in patients without pre-ILD was 2.2%. Risk factor analysis for the lung injury showed pre-ILD was the most predictable factor [odds ratio (OR) 5.00, p=0.07]. Combination with other agents, origin of neoplasms (lung or not), initial dose or minimum interval were not observed to be related to risk. Conclusion: The risk of lung injury with irinotecan was high when pre-ILD was present and the risk was comparable with previously reported other agents.
OUTCOME OF ABLATION IN NONPAROXYSMAL ATRIAL FIBRILLATION PATIENTS WITH SEVERE LEFT ATRIAL ENLARGEMENT AND ITS INFLUENCE ON LEFT ATRIAL REMODELING
Authors: Agnes Pump, Luigi Di Biase, Prasant Mohanty, Rong Bai, Pasquale Santangeli, Sanghamitra Mohanty, Javier Sanchez, Rodney Horton, David Burkhardt, Joe Gallinghouse, Andrea Natale
Journal: Journal of the American College of Cardiology (2012)
Paracetamol and the kidney.
Authors: D. M. Krikler
Journal: BMJ (1967)

Increased fibrinolytic activity in the blood of the superficial veins of hemiplegic arms as compared with that in the same veins on the normal side was observed in 20 out of 21 patients studied in whom hemiplegia had been present for up to two years.Possible explanations for this are discussed.
Past and future influences on public health
Authors: R Bhopal
Journal: BMJ (1994)

EDITOR, - At the summer scientific conference of the Faculty of Public Health Medicine the chief medical officer, Dr Kenneth Calman, challenged delegates to identify the most important influences on public health in the past 20 years and to predict the major influences in the next 20 years. Colleagues and I conducted a Delphi-type consultation (two rounds of comment and analysis) in this department and have now come close to a consensus. The box shows the results. #### Most important influences on public health in past and next 20 years Past** #### Future(dagger)
Preventing Firearm Violence
Authors: Del J. DeHart
Journal: Annals of Internal Medicine (1995)

Letters15 November 1995Preventing Firearm ViolenceDel J. DeHart, MDDel J. DeHart, MDSaginaw Cooperative Hospitals, Inc.; Saginaw, MI 48602Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-10-199511150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The American College of Physicians [1] has established its position in the gun control morass but stands on a precarious notion: that firearm violence is a public health issue in the sense that tuberculosis control and childhood immunizations are public health issues. Firearm violence is clearly a public safety issue, but I cannot envision our local health department workers regulating firearm ownership while they are arranging WIC services. I believe that labeling this social and moral problem as a public health failure is at best a well-intentioned but misguided effort to save lives. At worst, it is ...REFERENCE1. American College of Physicians. Preventing firearm violence: a public health imperative. Ann Intern Med. 1995; 122:311-3. Google Scholar Author, Article, and Disclosure InformationAffiliations: Saginaw Cooperative Hospitals, Inc.; Saginaw, MI 48602 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1995Volume 123, Issue 10Page: 813-813KeywordsChild healthFire safetyFirearm injuriesPrevention, policy, and public health Issue Published: 15 November 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Test of the Doman-Delacato Rationale With Retarded Readers
Authors: Melvyn P. Robbins
Journal: JAMA (1967)

An empirical test of the central concept and treatment efficacy of the Doman-Delacato rationale was implemented by investigating the influence of a program based on the theory of neurological organization on the reading development of retarded readers. The study employed a traditional control group and a nonspecific program, thought to simulate the placebo effect. The results failed to confirm the validity of the rationale— suggesting that verifiable, empirical evidence from carefully controlled studies is needed if the rationale is to be taken seriously by the scientific community.
T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells
Authors: Ruth Lyck, Yvonne Reiss, Nicole Gerwin, John Greenwood, Peter Adamson, Britta Engelhardt
Journal: Blood (2003)
Trends in Cigarette Smoking Among US Physicians and Nurses
Authors: David E. Nelson
Journal: JAMA (1994)

To determine trends in cigarette smoking prevalence among physicians, registered nurses, and licensed practical nurses since 1974.Analyses of data on smoking prevalence among persons 20 years of age and older using combined National Health Interview Survey data sets from 1974, 1976, and 1977; 1978, 1979, and 1980; 1983 and 1985; 1987 and 1988; and 1990 and 1991.Prevalence of cigarette smoking and average annual change in smoking prevalence.Based on the data for 1990 and 1991, there were an estimated 18,000 physicians, 322,000 registered nurses, and 128,000 licensed practical nurses who smoked cigarettes in the United States. Compared with 1974, 1976, and 1977, by 1990 and 1991 cigarette smoking prevalence had declined from 18.8% to 3.3% among physicians (average annual decline of 1.15 percentage points); from 31.7% to 18.3% among registered nurses (average annual decline of 0.88 percentage point); and from 37.1% to 27.2% among licensed practical nurses (average annual decline of 0.62 percentage point).Since 1974, cigarette smoking has declined most rapidly among physicians, at an intermediate rate among registered nurses, and at a lower rate among licensed practical nurses. Because of their important roles as exemplars and health educators, persons in these occupations should not smoke.
Production of Increased Right-to-Left Shunting by Rapid Heart Rates in Patients with Tetralogy of Fallot
Authors: SPENCER B. KING, ROBERT H. FRANCH
Journal: Circulation (1971)

A patient with tetralogy of Fallot who developed cyanosis and tachypnea during spontaneous attacks of paroxysmal atrial tachycardia had an increase in right-to-left shunting with a fall in arterial oxygen saturation from 96 to 43%. Duplication of the fast heart rate by atropine and atrial pacing reproduced these hemodynamic changes, while slowing the rate with propranolol reversed this effect. Subsequently, six patients with mild tetralogy of Fallot underwent rapid atrial pacing during cardiac catheterization. This primary increase in heart rate resulted in a fall in systemic oxygen saturation, an increase in percent right-to-left shunt, and an increase in the right ventricular outflow pressure gradient. These data suggest that further narrowing of the right ventricular infundibulum may occur during tachycardia. This experience indicates that paroxysmal atrial tachycardia should be added to the conditions that can cause increased cyanosis in some patients with tetralogy of Fallot. Other tachycardias may also augment right-to-left shunting.
Walsh and Hoyt's Clinical Neuro-Ophthalmology
Authors: Michael Rosenberg
Journal: JAMA (1982)

This book is the first volume of an anticipated three-volume work that will be the fourth edition of a text originally published by Dr Frank Walsh in 1947. The previous editions have been considered the "bible" by clinicians interested in the field of neuro-ophthalmology. This volume is a significant departure in style and format from previous editions. There are many more figures and newer illustrations, photomicrographs, and fundus photographs. The reproductions are generally excellent, and the author has taken advantage of large page size and improved photographic techniques to illustrate salient material. There is a marked reduction and abbreviation of case histories, which are not segregated from the text as in previous editions. References have been pruned and updated as well as possible and are grouped less diffusely. The book's 381 pages cover material presented in approximately 200 pages in the previous edition. Section 1, "The Visual Sensory System," contains
Implementation of Bronchoscopic Techniques in the Diagnosis of Ventilator-associated Pneumonia to Reduce Antibiotic Use
Authors: MARC J. M. BONTEN, DENNIS C. J. J. BERGMANS, ELLEN E. STOBBERINGH, SIEBE van der GEEST, PETER W. DE LEEUW, FRANK H. van TIEL, CARLO A. GAILLARD
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

In intensive care units, a large proportion of antibiotics are prescribed for presumed episodes of ventilator-associated pneumonia (VAP). VAP is usually diagnosed on a combination of clinical, radiographic, and microbiologic criteria with a high sensitivity but low specificity for VAP. As a result, patients may receive antibiotics unnecessarily. Specificity can be increased by the addition of quantitative cultures of samples of protected specimen brush (PSB) and bronchoalveolar lavage (BAL) to the diagnostic criteria. We prospectively analyzed the effects of implementation of PSB and BAL in the diagnosis of VAP on antibiotic prescription. PSB and/or BAL were performed in patients who fulfilled the clinical, radiographic, and microbiologic criteria for VAP. Based on quantitative cultures of PSB and/or BAL, patients were categorized into three groups: VAP microbiologically proven (Group 1; n = 72); clinical suspicion of VAP not confirmed microbiologically (Group 2; n = 66); and patients in whom bronchoscopy could not be performed (Group 3; n = 17). In Group 1, antibiotic therapy was instituted empirically in 40 patients (56%) (Group 1a) and after obtaining culture results in the other 32 patients (Group 1b). Adjustment of therapy, based on culture results, occurred in 14 (35%) patients in Group 1a. In Group 2, empiric therapy was instituted in 34 (52%) patients (Group 2a) and discontinued within 48 h in 17 of them (50%). In Group 3, 17 (100%) patients were treated with antibiotics. Among the 66 patients in whom a clinical suspicion of VAP was not confirmed, only 18 (27%) were treated with antibiotics, and antibiotic therapy was withheld in 48 (35%) of 138 patients who underwent bronchoscopy. Withholding of antibiotic therapy had no negative effect on the recurrence of a clinical suspicion of VAP or on mortality rates. We conclude that addition of bronchoscopic techniques to the criteria for VAP may help to reduce antibiotic use. However, the definite benefits and cost-effectiveness of these techniques should be analyzed in a randomized study.
Suppression of Liver Tumor Growth and Metastasis by Adiponectin in Nude Mice through Inhibition of Tumor Angiogenesis and Downregulation of Rho Kinase/IFN-Inducible Protein 10/Matrix Metalloproteinase 9 Signaling
Authors: Kwan Man, Kevin T.P. Ng, Aimin Xu, Qiao Cheng, Chung Mau Lo, Jiang Wei Xiao, Bai Shun Sun, Zophia X.H. Lim, Jerry S. Cheung, Ed X. Wu, Chris K.W. Sun, Ronnie T.P. Poon, Sheung Tat Fan
Journal: Clinical Cancer Research (2010)

Abstract Purpose: We aimed to investigate the effects of adiponectin on liver cancer growth and metastasis and explore the underlying mechanisms. Experimental Design: An orthotopic liver tumor nude mice model with distant metastatic potential was applied. Either Ad-adiponectin (1 × 108; treatment group) or Ad-luciferase (control group) was injected via portal vein after tumor implantation. Tumor growth and metastasis were monitored by Xenogen In vivo Imaging System. Hepatic stellate cell activation by α-smooth muscle actin staining, microvessel density by CD34 staining, macrophage infiltration in tumor tissue, and cell signaling leading to invasion, migration [Rho kinase (ROCK), IFN-inducible protein 10 (IP10), and matrix metalloproteinase 9], and angiogenesis [vascular endothelial growth factor (VEGF) and angiopoietin 1] were also compared. Tumor-nontumor margin was examined under electron microscopy. Direct effects of adiponectin on liver cancer cells and endothelial cells were further investigated by a series of functional studies. Results: Tumor growth was significantly inhibited by adiponectin treatment, accompanied by a lower incidence of lung metastasis. Hepatic stellate cell activation and macrophage infiltration in the liver tumors were suppressed by adiponectin treatment, along with decreased microvessel density. The treatment group had less Ki-67–positive tumor cells and downregulated protein expression of ROCK1, proline-rich tyrosine kinase 2, and VEGF. Tumor vascular endothelial cell damage was found in the treatment group under electron microscopy. In vitro functional study showed that adiponectin not only downregulated the ROCK/IP10/VEGF signaling pathway but also inhibited the formation of lamellipodia, which contribute to cell migration. Conclusion: Adiponectin treatment significantly inhibited liver tumor growth and metastasis by suppression of tumor angiogenesis and downregulation of the ROCK/IP10/matrix metalloproteinase 9 pathway. Clin Cancer Res; 16(3); 967–77
Trends in Predicted Risk for Atherosclerotic Cardiovascular Disease Using the Pooled Cohort Risk Equations Among US Adults From 1999 to 2012
Authors: Earl S. Ford, Julie C. Will, Carla I. Mercado, Fleetwood Loustalot
Journal: JAMA Internal Medicine (2014)

Risk assessment has become an important tool to assess an individual’s future risk for cardiovascular disease. Recently, the American College of Cardiology/American Heart Association (ACC/AHA) released a report that presented updated risk equations, the Pooled Cohort Risk Equations, for cardiovascular disease.1 Race and ethnicity-specific estimates were novel to the new risk equations. Because changes over time in predicted cardiovascular risk using these new risk equations have not been examined, our objectives were to (1) examine the trend in predicted 10-year cardiovascular risk using the new ACC/AHA Pooled Cohort Risk Equations and (2) estimate the potential for risk reduction by optimizing levels of cardiovascular risk factors.
The Future of Primary Care Medicine
Authors: Michael E. Whitcomb, Jordan J. Cohen
Journal: New England Journal of Medicine (2004)

During the early and mid-1990s, a consensus emerged among physicians and health care policymakers that the United States would have a substantial surplus of physicians by the end of the decade. Most people who held this view also believed that the surplus would be limited to non–primary care physicians and that, by contrast, the supply of physicians planning to practice primary care medicine would be barely adequate. This view was supported by the decrease in the late 1980s and early 1990s in the number of graduating medical students who chose residency training in specialties that could lead to careers in . . .
Endoscopic and Radiological Features of Intramural Esophageal Dissection
Authors: C.-C. Hsu, C.-S. Changchien
Journal: Endoscopy (2001)

A 41-year-old woman was admitted to our hospital complaining of chest pain, dysphagia, and odynophagia after an upper respiratory tract infection and nasogastric tube insertion. An upper endoscopy showed a large submucosal bulge along the posterior wall from the upper esophagus with mucosal tears and bridge formation, extending down to the lower esophagus. A barium esophagogram revealed a "double-barreled" esophagus, and chest computed tomography (CT) scan showed eccentric thickening of the esophageal wall. The diagnosis of intramural esophageal dissection (IED) was made and the patient was managed conservatively with nothing by mouth and intravenous hydration. The clinical course was uneventful; the patient was discharged later and up to the time of writing has been completely asymptomatic, with normal swallowing function.
The effect of intracutaneous glucocorticoids on plasma cortisol levels
Authors: S.T. ZAYNOUN, IBRAHIM S. SALTI
Journal: British Journal of Dermatology (2006)

The effects of intracutaneous injections of preparations of equal parts of betamethasone disodium phosphate and betamethasone acetate (Celestone Chronodose®) and triamcinolone acetonide (Kenacort-A®) on plasma cortisol levels were studied. Significant suppression of plasma cortisol lasting from 3 to 13 days was observed with various doses of the first preparation. With triamcinolone acetonide, there was only a mild and transient suppression.
Taenia Saginata Diagnosed as Digitalis Toxicity
Authors: ROGER S. KAUFMAN
Journal: Annals of Internal Medicine (1961)

Case Reports1 October 1961Taenia Saginata Diagnosed as Digitalis ToxicityROGER S. KAUFMAN, M.D.ROGER S. KAUFMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-4-679 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTapeworm infections occur infrequently in the United States (1) and those that do appear are usually subclinical. It is even less common for tapeworm infestation to occur in a patient also suffering from diabetes mellitus, Laennec's cirrhosis, and arteriosclerotic heart disease.The purpose of this paper is to report a case of diarrhea and protracted weight loss in a 72-year-old male, which was originally attributed to digitalis toxicity and diabetes mellitus. The patient himself furnished the diagnosis by spontaneously passing an extensive segment of Taenia saginata proglottids.CASE REPORTA 72-year-old white male was admitted to the Urology Service of...References1. MOST H: Current concepts in therapy: I. Antihelminthic therapy. New Engl. J. Med. 259: 341, 1958. MedlineGoogle Scholar2. SCHREIBER W: Intraduodenal therapy for taenia, hookworm, and strongyloides infection. Gastroenterology 37: 346, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaReceived for publication October 26, 1960.From the Urology Department of the Pennsylvania Hospital, Philadelphia, Pa.Requests for reprints should be addressed to Roger S. Kaufman, M.D., Columbia-Presbyterian Medical Center, 230 W. 168th St., New York 32, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTaeniasis and Cysticercosis (Taenia saginata) 1 October 1961Volume 55, Issue 4Page: 679-680KeywordsCardiovascular therapyCirrhosisDiabetes mellitusDiarrheaToxicityUrologyWeight loss Issue Published: 1 October 1961 PDF DownloadLoading ...
BMA remains concerned about GMC structure
Authors: L. Beecham
Journal: BMJ (2001)

The BMA has called for an “independent body” to investigate and recommend a structure for a reformed General Medical Council if the current negotiations between the council and the profession's representatives fail to result in a satisfactory conclusion.

The BMA's annual meeting in Bournemouth last week passed the motion as a reference after the chairman of the council, Dr Ian Bogle, reported that further talks were due to take place this month. The BMA's council will discuss any new proposals on 18 July, and the GMC will hold a special meeting to finalise the proposals.

The meeting agreed that the GMC should remain a professionally …
Apolipoprotein A-I and platelet factor 4 are biomarkers for infliximab response in rheumatoid arthritis
Authors: C Trocmé, H Marotte, A Baillet, B Pallot-Prades, J Garin, L Grange, P Miossec, J Tebib, F Berger, M J Nissen, R Juvin, F Morel, P Gaudin
Journal: Annals of the Rheumatic Diseases (2008)

<h3>Objectives:</h3> The use of biologicals such as infliximab has dramatically improved the treatment of rheumatoid arthritis (RA). However, factors predictive of therapeutic response need to be identified. A proteomic study was performed prior to infliximab therapy to identify a panel of candidate protein biomarkers of RA predictive of treatment response. <h3>Methods:</h3> Plasma profiles of 60 patients with RA (28 non-responders (as defined by the American College of Rheumatology 20% improvement criteria (ACR20)) negative and 32 responders (ACR70 positive) to infliximab) were studied by surface enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS) technology on two types of arrays, an anion exchange array (SAX2) and a nickel affinity array (IMAC3-Ni). Biomarker characterisation was carried out using classical biochemical methods (purification by ammonium sulfate precipitation or metal affinity chromatography) and identification by matrix assisted laser desorption/ionisation time-of-flight (MALDI-TOF) MS analysis. <h3>Results:</h3> Two distinct protein profiles were observed on both arrays and several proteins were differentially expressed in both patient populations. Five proteins at 3.86, 7.77, 7.97, 8.14 and 74.07 kDa were overexpressed in the non-responder group, whereas one at 28 kDa was increased in the responder population (sensitivity&gt;56%, specificity&gt;77.5%). Moreover, combination of several biomarkers improved the sensitivity and specificity of the detection of patient response to over 97%. The 28 kDa protein was characterised as apolipoprotein A-I and the 7.77 kDa biomarker was identified as platelet factor 4. <h3>Conclusions:</h3> Six plasma biomarkers are characterised, enabling the detection of patient response to infliximab with high sensitivity and specificity. Apolipoprotein A-1 was predictive of a good response to infliximab, whereas platelet factor 4 was associated with non-responders.