tbuckley/cabot-search huggingface dataset:
P770Method to enhance immunofluorescence detection of cardiovascular biomarkers
Authors: B Khaw, XD Wang, P Bhattaria, A Pandey, WT Chan
Journal: Cardiovascular Research (2014)

Changes in bio-marker expression in various cardiovascular disorders can be demonstrated by mRNA expression concentration and cardiac proteins by ELISA, histology, immunohistology or immunofluorescence. The latter methods are less sensitive but are cheaper. We now report the development of enhanced immunofluorescence detection of a cardiovascular biomarker, cardiac myosin (CM), by immunofluorescence microscopy and flow cytometry using pretargeting of CM with bispecific antibody (bsAb) and targeting with multi-Rhodamine conjugated negatively charged polymers that show signal amplification, no fluorescence quenching and low background activity.
Research in Physical Medicine
Authors: Arthur L. Watkins
Journal: New England Journal of Medicine (1946)

EVALUATION of any therapeutic agent, including physical therapy, must be gauged by its effect on patients and based on knowledge of physiologic action. Scientific investigation in the field of physical medicine is difficult because of the wide variety of agents employed — massage, therapeutic exercise, water, air, radiations (heat, light and ultraviolet rays), vibrations (mechanical and sound) and electricity in various forms. The conditions treated are often ill defined regarding etiology and pathology, and prescription of physical therapy is consequently often empirical, with hope entertained for symptomatic relief. In spite of these well known shortcomings, there is some background of . . .
Predictors of Thromboembolism in Atrial Fibrillation
Authors: Sonya Vaziri, Mahesh Bikkina, Daniel Levy
Journal: Annals of Internal Medicine (1992)

Letters1 July 1992Predictors of Thromboembolism in Atrial FibrillationSonya Vaziri, MD, Mahesh Bikkina, MD, Daniel Levy, MDSonya Vaziri, MDSearch for more papers by this author, Mahesh Bikkina, MDSearch for more papers by this author, Daniel Levy, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-1-89 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:In their recent analysis, the Stroke Prevention in Atrial Fibrillation (SPAF) investigators (1) concluded that a history of hypertension, recent congestive heart failure, and previous thromboembolism are important clinical features that identify patients with nonrheumatic atrial fibrillation at high risk for thromboembolism. The therapeutic implications of this analysis deserve comment. Sixty-three percent of the patients were in the warfarin-ineligible, placebo arm of the study, and the remainder of the patients were drawn from the warfarin-eligible, placebo arm. Thus, conclusions about the value of prophylactic anticoagulant therapy (but not antiplatelet therapy) in this study sample are unclear. Analysis...References1. . Predictors of thromboembolism in atrial fibrillation: I. Clinical features of patients at risk. Ann Intern Med. 1992;116:1-5. LinkGoogle Scholar2. KannelWolfVerterMcNamara WPJP. Epidemiologic assessment of the role of blood pressure in stroke: the Framingham study. JAMA. 1970;214:301-10. CrossrefMedlineGoogle Scholar3. . Stroke Prevention in Atrial Fibrillation Study: final results. Circulation. 1991;84:527-39. CrossrefMedlineGoogle Scholar1. . Stroke Prevention in Atrial Fibrillation Study: final results. Circulation. 1991;84:527-39. CrossrefMedlineGoogle Scholar1. Stroke Prevention in Atrial Fibrillation Study: final results. Circulation. 1991;84:527-39. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Framingham Heart Study Framingham, MA 01701 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMorphological and functional characteristics of mitral annular calcification and their relationship to strokeEACVI/EHRA Expert Consensus Document on the role of multi-modality imaging for the evaluation of patients with atrial fibrillationHypertension, inflammation and atrial fibrillation 1 July 1992Volume 117, Issue 1Page: 89-90KeywordsAnticoagulant therapyAntiplatelet therapyAtrial fibrillationHeart failureHypertensionStrokeThromboembolism Issue Published: 1 July 1992 PDF downloadLoading ...
Frequency and nature of the variant syndromes of autoimmune liver disease
Authors: Albert J. Czaja
Journal: Hepatology (1998)

To determine the frequency and nature of variant syndromes in autoimmune liver disease, 162 patients with type 1 autoimmune hepatitis, 37 patients with primary biliary cirrhosis, and 26 patients with primary sclerosing cholangitis were assessed in a uniform fashion, and the strength of the original diagnosis was evaluated by use of a scoring system. Variant forms, including syndromes with autoimmune hepatitis and primary biliary cirrhosis (7%) or primary sclerosing cholangitis (6%) and autoimmune cholangitis (11%), were common in the 225 patients (18%). Individuals with autoimmune hepatitis and primary biliary cirrhosis entered remission during corticosteroid therapy as commonly as individuals with definite autoimmune hepatitis (75% vs. 64%, P = .5), and they responded better than patients with autoimmune hepatitis and primary sclerosing cholangitis (75% vs. 22%, P = .03) or autoimmune cholangitis (75% vs. 0%, P = .009). Patients with autoimmune hepatitis and primary sclerosing cholangitis had a higher frequency of a poor result than other variants (78% vs. 17%, P = .04), and they died of liver failure or required liver transplantation more often than patients with definite autoimmune hepatitis (33% vs. 8%, P = .05). None of the patients entering remission had serum alkaline phosphatase levels greater than twofold the reference value. In conclusion, variants of autoimmune liver disease are common. Corticosteroid therapy can be effective in patients with features of autoimmune hepatitis and primary biliary cirrhosis. A serum alkaline phosphatase level of less than twofold the reference value characterizes corticosteroid-responsive individuals.
Parikh's Text Book of Medical Jurisprudence and Toxicology for Classrooms and Courtrooms
Authors: Robert J. Stein
Journal: JAMA (1981)

<i>Parikh's Text Book of Medical Jurisprudence and Toxicology</i>, is primarily intended for use by Indian practitioners of law and medicine. The book is a potpourri of many fields, some covered in depth and some superficially. The book is divided into three parts (medical jurisprudence, toxicology, and appendix) and nine sections. The five sections (680 pages) of part 1 deal with the entire field of forensic pathology, including forensic immunohematology, examination of hair, and clinical forensic medicine (impotence, sterility, virginity, pregnancy, sexual offenses, etc). Also included in part 1, section 5, are such topics as forensic psychiatry, law in relation to the physician, forensic science laboratories and crime detection, the Indian penal code, criminal procedure code, and the Indian Evidence Act. In part 1 are many excellent features and some very poor ones. The former are the tables, summaries, definitions, and diagrams. The poor features are the photographs, which by other
Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery
Authors: Zhiping Zhang, Songsak Tongchusak, Yo Mizukami, Yoon Joong Kang, Tetsuya Ioji, Maki Touma, Bruce Reinhold, Derin B. Keskin, Ellis L. Reinherz, Tetsuro Sasada
Journal: Biomaterials (2011)
The CONSORT Statement: Revised Recommendations for Improving the Quality of Reports of Parallel-Group Randomized Trials
Authors: David Moher, Kenneth F. Schulz, Douglas G. Altman
Journal: Annals of Internal Medicine (2001)

To comprehend the results of a randomized, controlled trial (RCT), readers must understand its design, conduct, analysis, and interpretation. That goal can be achieved only through complete transparency from authors. Despite several decades of educational efforts, the reporting of RCTs needs improvement. Investigators and editors developed the original CONSORT (Consolidated Standards of Reporting Trials) statement to help authors improve reporting by using a checklist and flow diagram. The revised CONSORT statement presented in this paper incorporates new evidence and addresses some criticisms of the original statement. The checklist items pertain to the content of the Title, Abstract, Introduction, Methods, Results, and Discussion. The revised checklist includes 22 items selected because empirical evidence indicates that not reporting the information is associated with biased estimates of treatment effect or because the information is essential to judge the reliability or relevance of the findings. We intended the flow diagram to depict the passage of participants through an RCT. The revised flow diagram depicts information from four stages of a trial (enrollment, intervention allocation, follow-up, and analysis). The diagram explicitly includes the number of participants, for each intervention group, that are included in the primary data analysis. Inclusion of these numbers allows the reader to judge whether the authors have performed an intention-to-treat analysis. In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results. *For a list of contributors to the CONSORT statement, see Appendix.
RARβ1′: Primed To Fight Retinoid Resistance in Lung Carcinogenesis
Authors: Anita L. Sabichi, Xiaochun Xu, Scott M. Lippman
Journal: JNCI Journal of the National Cancer Institute (2005)

Retinoids (vitamin A and its natural and synthetic analogues) have a strong preclinical record of anticarcinogenic activity in a broad range of tissue types ( 1 ) . The promise of this record, however, has not been realized in clinical trials of retinoids in preventing lung cancers. The inability of retinoids to prevent second primary lung cancers in the phase III European Study on Chemoprevention with Vitamin A and N -Acetylcysteine (EUROSCAN) ( 2 ) and the Lung Intergroup Trial (LIT) ( 3 ) has substantially dampened the enthusiasm for further exploring retinoids for lung cancer treatment and prevention. The provocative article by Petty et al. ( 4 ) on a new retinoid receptor and retinoid resistance in lung cancer lights a spark that may help to rekindle interest in retinoids for cancer chemoprevention. Retinoid effects, such as modulating cell growth, differentiation, and apoptosis, are mediated by nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). These receptors are members of the steroid hormone receptor gene superfamily, bind to the naturally occurring all- trans -RA (RARs) and 9- cis RA (RXRs), and are essential for the differentiation and maintenance of normal epithelium. RARs and RXRs each have three subtypes ( α , β , and γ ) with distinct amino- and carboxy-terminal domains ( 5 ) . Disruption of the pathway of, and hence responsiveness to, retinoids may contribute to cancer development and ac
Gametocytemia in Falciparum Malaria
Authors: Steven J. Berman
Journal: JAMA (1971)

<i>Following successful treatment of a patient with falciparum malaria which was acquired in Vietnam, persistent gametocytemia was noted. Since recent studies suggest such gametocytes remain infective for the</i>Anopheles<i>vector, undetected gametocytemia could lead to the reintroduction of falciparum malaria in this country. Treatment with primaquine phosphate will eradicate</i>Plasmodium falciparum<i>gametocytes, and is recommended for prevention of transmission of falciparum malaria</i>.
Typhoid Genome Decoded
Authors: Joan Stephenson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Venereal Disease and Homosexuality
Authors: Warren A. Ketterer
Journal: JAMA (1964)

SPREAD OF venereal diseases by homosexuals has been recognized throughout the world as well as in the United States,<sup>1-3</sup>but relatively little has been published on the subject. Although there is increasing awareness of the problem, there is concern whether physicians and health departments are fully prepared to provide proper medical, public health, and epidemiological measures, including confidential handling of information.<sup>4,5</sup>The purpose of this communication is to bring into focus some significant medical and public health considerations and practices. The material presented is based on venereal disease conferences held in California, experiences in local venereal disease programs, and review of the literature. <h3>Incidence.—</h3> Health workers find varying degrees of homosexual implication in the spread of venereal disease. The highest percentage occurs with infectious syphilis, a far lower percentage with gonorrhea. The degree to which homosexuality is implicated in a local venereal disease problem appears to be proportionate
Symposium on Skin Diseases Common to Man and Animals
Authors: Milton Orkin
Journal: JAMA (1966)

"There is but one medicine," observed Sir William Osler. Any dividing line between veterinary and human medicine is artificial. One of the first attempts to make the knowledge of veterinary medicine available to dermatology was the work of Julius Heller published in 1910, under the title<i>Comparative Pathology of the Skin</i><sup>1</sup>; he elaborated on this subject in Jadassohn's Handbook (1930).<sup>2</sup>There was a long interval until the publication of Kral and Novak's book on veterinary dermatology in 1953.<sup>3</sup>Indicative of intense, recent interest in comparative dermatology is the publication in the past four years of three textbooks on this subject, viz, those of Schwartzman and Orkin,<sup>4</sup>Kral and Schwartzman,<sup>5</sup>and Rook and Walton.<sup>6</sup>The last comprises the proceedings of a symposium on comparative physiology and pathology of the skin (Cambridge, England, April 1964). Comparative studies require the teamwork of veterinarian, physician, and frequently zoologist
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
Authors: Pekka Katajisto, Kari Vaahtomeri, Niklas Ekman, Eeva Ventelä, Ari Ristimäki, Nabeel Bardeesy, Robert Feil, Ronald A DePinho, Tomi P Mäkelä
Journal: Nature Genetics (2008)
Streptomycin Treatment of Infantile Diarrhoea and Vomiting
Authors: A. Holzel, G. Martyn, L. Apter
Journal: BMJ (1949)

STREPTOMYCIN IN SEPTICAEMIA AND MENINGITISBsDIH}RAL mechanism of producing ventricular block, but it is certain that they affected the circulation of the cerebrospinal fluid and the diffusion of streptomycin injected subthecally. CommentWe cannot close this paper without remarking on the relative frequency of infection by intestinal organisms in infants.In many circumstances saprophytic organisms in the digestive tract of the newborn become pathogenic and produce bacteriaemia, septicaemia, and meningitis.It is significant that in 18 months we have been able to observe in the Clinique Medicale des Enfants 41 cases of this type of infection, 25 of which developed meningitis.The signs of these infections are often obscure at first sight, and many of the cases can be discovered only by the careful examination of infants suffering from toxaemia and subacute fever with alimentary disturbances.A search must be made for the organism in blood, marrow, stools, urine, pus from the ear, cerebrospinal fluid, nasopharyngeal secretions, and pus from any metastatic sup- puration in the skin.Repeated blood culture is extremely important.The occurrence during a gastro-intestinal ill- ness of an inexplicable alteration in the patient's general condition or, as we have shown, a polymorphonuclear leucocytosis, is a diagnostic sign of great importance.The possibility of meningeal infection must always be considered, and lumbar puncture, repeated if necessary, must be done as a routine measure.At the same time it must be remembered that the cerebrospinal fluid may be normal or be little changed.SummaryAn account is given of 41 cases of infection in the infant by intestinal organisms, seen over a period of 18 months.Of these cases 16 had ,septicaemia alone and 25 developed meningitis.The clinical features of the condition are discussed, and an account is given of treatment with streptomycin given by the intramuscular, oral, intrathecal, and intraventricular routes.A method of assaying the sensitivity of organisms to streptomycin in vitro is discussed.
Beyond cry and laugh: Toward a multilevel model of language production
Authors: Marc H. Bornstein, Gianluca Esposito
Journal: Behavioral and Brain Sciences (2014)

Abstract Language production is a multilevel phenomenon, and human capacities to communicate vocally progress from early forms, based on projections of motor cortex to brainstem nuclei, to complex elaborations, mediated by high-order cognition and fostered by socially mediated feedback.
LECTURE ON SUBCUTANEOUS BLOOD-INJECTIONS, SALT WATER INFUSION, AND INTRAVENOUS TRANSFUSION.
Authors: H. von ZIEMSSEN
Journal: JAMA (1887)

The diseased conditions in which a renewal or repair of the blood seems necessary are so numerous,that the pertinacity with which the question of transfusion is again and again brought before the physician, despite repeated reverses, is easily explained. It is well known that the enthusiasm over the transfusion of the blood of animals (such as sheep), into the human circulation, was brought to an end by the dangers of the operation, and by the publication of the works of Landois, Ponfick, and Panum, which showed that the blood of one species cannot be safely transfused into another species.  At this time (1870-1873) I was experimenting with subcutaneous blood injections, and made a series of subcutaneous injections of animals' blood (lamb, calf, cow) in cases of various diseases in men. The results were anything but satisfactory, as on the one hand there were no noteworthy favorable results, and on the
Abstract 5598: A comprehensive study to analyze tumor sensitivity to HSP90 inhibition therapy.
Authors: Matthew Riolo, Shanu Modi, Adriana Corben, Clifford Hudis, Mary Alpaugh, Gabriela Chiosis
Journal: Cancer Research (2013)

Abstract There have been great advances in receptor-targeted breast cancer therapeutics. However, limited sensitivity and tumor resistance remain significant problems for many patients. To overcome these obstacles our laboratory has focused on targeting HSP90, a global mediator of oncogenic pathways involved in nearly all cancer types. Our laboratory has developed PU-H71 which selectively inhibits oncogenic HSP90 and is one of the first targeted therapies to show preclinical potent activity in the treatment of triple negative breast cancers. Here, we investigate how the complex biology of different types of breast tumors influences response to HSP90 inhibition. Our preliminary data indicate that sensitivity to PU-H71 goes beyond a tumor's receptor status and is highly driven by its intracellular protein composition. Our objective is to identify specific pharmacodynamic changes in select HSP90 onco-client proteins and regulators of apoptosis associated with HSP90 inhibition as a tool to monitor therapeutic response. Using several different breast cancer cell lines we evaluate how alterations in specific onco-client phosphorylated species as well as the induction of pro-apoptotic protein cleavage correlates to a tumor's sensitivity to HSP90 inhibition. In addition to testing cell lines, we have developed a system to investigate PU-H71 on primary tumors by treating surgery specimens ‘ex vivo’ (fresh tissue sectioning) to determine response and pharmacodynamic alterations in patient samples. Our long term goal is to establish specific pharmacodynamic changes (PD markers) that correlate to tumor sensitivity allowing us to better predict those patients more likely to benefit from HSP90 inhibition i.e. PU-H71 therapy. Citation Format: Matthew Riolo, Shanu Modi, Adriana Corben, Clifford Hudis, Mary Alpaugh, Gabriela Chiosis. A comprehensive study to analyze tumor sensitivity to HSP90 inhibition therapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5598. doi:10.1158/1538-7445.AM2013-5598
Positive Tc-99m-MIBI Scan in a Patient With Confirmed Paget??s Disease of Bone
Authors: Adonios Zanglis, Demetrios Andreopoulos, Athanassios Zissimopoulos, Nikolaos Baziotis
Journal: Clinical Nuclear Medicine (2005)

A 46-year-old man was referred to our department for a Tc-99m MDP bone scan after he was admitted to our hospital with diffuse bone pain and the subsequent finding of multiple mixed type (lytic-blastic) lesions on routine x-rays. The Tc-99m MDP scan was highly suspicious for malignancy and, therefore, a Tc-99m MIBI scan was performed, which also revealed abnormal uptake in all regions with increased osteoblastic activity. Clinical chemistry and further workup revealed a highly elevated serum alkaline phosphatase and increased excretion of hydroxyproline in the urine. The presumed diagnosis of Paget's disease of the bone was further confirmed by biopsy.
ABNORMALITIES OF 3D STRAIN ARE RELATED TO SIGNIFICANT CORONARY ARTERY DISEASE AND IDENTIFY THE LEFT VENTRICULAR ISCHEMIC TERRITORY
Authors: Valentina Parisi, None Piccolo, Gennaro Galasso, Claudio De Lucia, Raffaele Piccolo, Giuseppe Rengo, roberta de rosa, Grazia Daniela Femminella, Dario Leosco, Gennaro Pagano, Nicola Ferrara, Federico Piscione
Journal: Journal of the American College of Cardiology (2013)
Easing pain or hastening death?
Authors: N P Sykes
Journal: BMJ (1987)

In this scheme a "new" NHS built from the skill and experience of the old one for major conditions and an independent health service for routine conditions would be entirely complementary to each other.Margaret Thatcher has the op- portunity, ability, and courage to implement this sort of radical surgery before health care in Britain becomes an incurable lost cause, both for those delivering it and, even worse, for those needing it.