tbuckley/cabot-search huggingface dataset:
Multiple Endocrine Adenomatosis.
Authors: Boy Frame
Journal: Annals of Internal Medicine (1964)

s1 February 1964Multiple Endocrine Adenomatosis.Boy Frame, M.D., F.A.C.P., R. J. Hartstock, M.D., H. S. Ballard, M.D.Boy Frame, M.D., F.A.C.P.Search for more papers by this author, R. J. Hartstock, M.D.Search for more papers by this author, H. S. Ballard, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-330_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe parathyroids, pancreatic islets, adrenals, and pituitary are the glands most frequently involved in the syndrome of multiple endocrine adenomatosis (MEA). In more than 50% of the reported cases peptic ulcer has been observed.In a Negro family extending over five generations, 13 of 25 members had evidence of the MEA syndrome. Hyperparathyroidism was the most commonly recognized feature occurring in 10 of 13 affected members. Peptic ulcer occurred in 9 members and 5 died of complications secondary to ulcer perforation. Seven of the family were known to have one or more nonbeta islet cell adenomas, and 5 members were... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 330-330KeywordsAdenomasEndocrine adenomatosisHyperparathyroidismParathyroidPeptic ulcers Issue Published: 1 February 1964 PDF downloadLoading ...
Unexpected effects of fasting on murine lipid homeostasis – Transcriptomic and lipid profiling
Authors: Milka Sokolović, Aleksandar Sokolović, Cindy P.A.A. van Roomen, Anna Gruber, Roelof Ottenhoff, Saskia Scheij, Theodorus B.M. Hakvoort, Wouter H. Lamers, Albert K. Groen
Journal: Journal of Hepatology (2010)
The Role of Tax Reform in Health Care Reform
Authors: James S. Floyd, Sidney M. Wolfe, Marcia Angell
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence for drugs in mental illness is flawed
Authors: N. Thomas
Journal: BMJ (2011)

Clinical trials to advance the diagnosis and treatment of Alzheimer disease (AD) may expose research subjects to discrimination risks. An individual enrolled in a research study that uses positive test results from amyloid PET imaging or CSF measures of β-amyloid 42 as inclusion criteria has biomarkers indicative of AD pathology. If insurers and employers learn this information, it could expose subjects to discrimination. Unfortunately, current legal and regulatory mechanisms are not sufficient to protect against harms that have significant consequences for subjects. Existing law that prohibits employment and insurance discrimination based on genetic status does not apply to amyloid biomarkers or any other biomarkers for neurodegenerative diseases. Gaps in legal protections fail to protect research subjects from discrimination by long-term care and disability insurers. This risk is particularly concerning because individuals with AD dementia ultimately need long-term care services. To maximize subject protections and advance valuable research, policymakers, investigators, and research institutions must address shortcomings in the design of the electronic medical record, revise laws to limit discrimination, and develop practices that inform research participants of risks associated with loss of confidentiality.
Defects in sphygmomanometers: an important source of error in blood pressure recording.
Authors: S Conceicao, M K Ward, D N Kerr
Journal: BMJ (1976)

Almost half the sphygmomanometers in a teaching hospital group had defects in the control valve which interfered with accurate blood-pressure reading. Ward staff should be taught to check sphygmomanometers regularly and replace control valves; time consumption and cost are low. The cuffs in general use in these hospitals, and of the standard size sold in Britain, had rubber bags which did not encircle the arm of more than half the patients on whom they were used. This deficiency causes over-reading of blood pressure in obese people. The size of error is uncertain but it should be avoided by adopting a cuff with a longer bag.
On the Path of the Excitation Wave in Atrial Flutter
Authors: GEORGE R. STIBITZ, DAVID A. RYTAND
Journal: Circulation (1968)

Available data on the arrival times of excitation at various central and peripheral atrial sites during atrial flutter (in a number of dogs and in one patient) have been examined in relation to families of involutes of an arbitrary central obstacle. The degree of fit seems to be satisfactory and is superior to that made for the same data by central-centrifugal (mother-daughter) waves. The latter appear to be an erroneous corollary of the circus movement hypothesis. In contrast, the concept that successive wave fronts of an entrapped circuit wave in atrial flutter may be described by a family of involutes has an appropriate physiological basis in the construction of Huygens, as first suggested by Wiener and Rosenblueth.
A case of syndrome of inappropriate secretion of antidiuretic hormone following endoscopic treatment
Authors: M. Tajika, T. Nakamura, J. Tsuboi, V. Bhatia, H. Kawai, A. Sawaki, N. Mizuno, T. Takagi, K. Hara, Y. Sawai, Y. Kobayashi, K. Matsumoto, S. Sugimori, K. Yamakita, K. Yamao
Journal: Endoscopy (2009)

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after endoscopic treatment has never been described. We report the first case of this complication after a relatively minor endoscopic procedure.
Curbing the Opioid Epidemic in the United States
Authors: Lewis S. Nelson, Jeanmarie Perrone
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Remission of symptoms in carcinoid syndrome with a new 5-hydroxytryptamine M receptor antagonist.
Authors: J V Anderson, M O Coupe, J A Morris, H J Hodgson, S R Bloom
Journal: BMJ (1987)

thyroid.'It is rare for benign goitre to cause paralysis ofthe cord.2In the only previous case report ofa thyroid cyst causing unilateral recurrent nerve palsy the patient had a seven year history of hoarseness and goitre.3Rapidly progressive bilateral recurrent laryngeal nerve palsy secondary to acute enlargement of a cyst has not been reported.It is difficult to explain the rapid onset of bilateral nerve compression and the sudden relief of symptoms by operation.Rapid expansion ofa cyst, with a sudden general increase in pressure within the confines of the pretracheal fascia sufficient to impair the microcirculation to both recurrent nerves, seems the most likely mechanism-in other words, a pretracheal compart- ment syndrome.The fact that this does not occur more often may relate to the great variability of this fascial layer and its relations with the recurrent laryngeal nerves.The nerves may be within the fascial compartment proper, invested by the fascial sheath itself, or completely outside the compartment for the whole of their course.4Percutaneous needle aspiration of such a cyst is likely to relieve the pressure on the recurrent nerves sufficiently to reduce dyspnoea and stridor before definitive surgery.This is proposed as the initial treatment when acute enlargement of the cyst or haemorrhage within it compromises the upper airway.I Lawson VG.The management of airway involvement in thyroid tumours.
Massive Air Embolism in a Neonate with Pulmonary Hypoplasia
Authors: Gim H Tan, Jeffrey B Sussmane
Journal: New England Journal of Medicine (2002)

At birth this baby girl was found to have left pneumohydrothorax and marked pulmonary hypoplasia that was treated with mechanical ventilation. After continued deterioration, she received high-frequency oscillatory ventilation. Her intraarterial pressure wave form dampened, and surgical exploration revealed air, but no blood, in the carotid artery.
Metallothionein-3 (MT-3) in the Human Adrenal Cortex and its Disorders
Authors: Saulo J. A. Felizola, Yasuhiro Nakamura, Yuki Arata, Kazue Ise, Fumitoshi Satoh, William E. Rainey, Sanae Midorikawa, Shinichi Suzuki, Hironobu Sasano
Journal: Endocrine Pathology (2013)
INEQUALITY OF THE PUPILS OBSERVED AT AN ALTITUDE OF TEN THOUSAND TWO HUNDRED AND FIFTY FEET.
Authors: E. T. BOYD
Journal: JAMA (1898)

The time when it was thought possible to foretell the character of insanity by noting which was the larger pupil has long since passed away. It is also my opinion that when the influence of great altitude upon the general economy shall be better understood, the time when we, as physicians, were inclined to regard inequality of the pupils as more than presumptive evidence of serious lesions, will have become ancient history. My reasons for bringing this subject (anisocoria) to your notice are many, the main one being to impress upon you that there may be unequal dilatation of the pupils which is in no way indicative of the lesions to which we are commonly in the habit of attributing it. So far as I can learn, but little has been written upon the subject, and that little deals with it as a symptomatic manifestation of graver troubles, such as
Eczematous infiltrated plaques to subcutaneous heparin: a type IV allergic reaction
Authors: A.J. BIRCHER, R. FLÜCKIGER, S.A. BUCHNER
Journal: British Journal of Dermatology (2006)

Two patients are described who had delayed reactions with eczematous plaques to subcutaneous injections of heparin. Subcutaneous challenge with high and low molecular weight heparin compounds were positive in both patients. Patch and intradermal tests with heparin were positive in one subject. Histological and immunohistochemical studies indicated that it was a type IV allergic reaction.
PROLONGED MAINTENANCE OF SPIROCHETES AND FILTRABLE VIRUSES IN THE FROZEN STATE
Authors: Thomas B. Turner, William L. Fleming
Journal: The Journal of Experimental Medicine (1939)

1. Observations are reported on the virulence of various types of spirochetes and filtrable viruses after storage at - 787deg;C. for periods up to 3 years. 2. Five specimens of Treponema pallidum belonging to 4 different strains, and 7 specimens of T. pertenue belonging to 5 different strains were tested after storage for approximately 3 years. With one exception each specimen contained actively motile treponemes, and all specimens were highly pathogenic for rabbits. Many other specimens of these spirochetes stored for shorter periods were also tested with similar results. 3. Relapsing fever spirochetes tested after storage from 6 months to 1 year showed active motility and were virulent for mice. 4. Leptospira icterohemorrhagiae was found to be actively motile after storage for 5, 6, and 10 months. The spirochete of rat bite fever, Spirillum minus, was virulent for mice after storage for 1 year. 5. The virus of human influenza, PR8 strain, tested after storage for approximately 3 years was fatal to mice in essentially the same dilution as was the same lot of material before freezing. Similar results were obtained upon testing the virus of meningopneumonitis after storage for 3 years. The virus of lymphogranuloma inguinale was pathogenic for mice after storage for 10 months.
Cadmium uptake from feed and its distribution to food products of livestock
Authors: R. P. Sharma, J. C. Street, M. P. Verma, J. L. Shupe
Journal: Environmental Health Perspectives (1979)

Distribution of cadmium (Cd) into the edible products of three species of food-producing animals was investigated during long-term dietary administration of supplemental cadmium chloride.Cows were exposed to 0.2 (control), 2.4, and 11.3 ppm Cd on whole ration basis for a period of three months followed by a three-month period on control ration. No accumulation of Cd occurred in milk, muscle, or bone at any of the time periods. A dose-related increase of Cd was observed in liver and kidney. The Cd concentration in these organs showed a gradual rise even when the animals were given control ration for three months after an initial three-month exposure to Cd; this observation suggests a mobilization and redistribution of this metal from other tissues.Dietary Cd levels in swine rations were 0.2, 2.4, and 10.1 ppm. The highest level of Cd produced a slightly reduced growth rate in swine. No accumulation of Cd was observed in muscle, bone, or brain. Liver and kidney showed a treatment and time-related increase in cadmium values at 6 and 12 weeks on experiment. During a three-month depletion phase after an initial three months of Cd administration, no further change in liver and kidney Cd levels was observed.White Leghorn chickens were treated by administering 0.3, 1.9, and 13.1 ppm Cd in their diets for up to 6 months. No accumulation of Cd occurred in eggs or bones. A slight increase of Cd level was observed in chicken muscle after six months of exposure. Liver and kidney had the highest levels of Cd, which showed a dose and time-related increase in these organs. No depletion of liver and kidney Cd was seen during seven weeks following a six-week treatment period.In all three species, the kidney Cd levels were severalfold higher than those of liver at all dietary levels. In swine, the renal cortex and medulla had similar Cd concentration in control animals but in all animals exposed to supplemental Cd, a dramatic rise in Cd levels in renal cortex was observed. Medullary Cd did not show a proportional time and dose-related increase in Cd levels, although the levels showed some increase. In kidney and liver of all three species the Cd levels showed a positive correlation with the amount of Cd-binding protein in these tissues. Induced levels of this metal-binding protein may explain accumulation and persistence of Cd-residues in these organs. In all three species, the concentrations of renal Cd-binding protein increased at a rate greater than those in liver.Although the food-producing animals may act as an effective filter of Cd in the case of an environmental increase of this metal, consumption of visceral organs from such animals may pose a hazard. This is particularly critical since the daily intake of Cd in human diet is already estimated to exceed the tolerance limits suggested by WHO/FAO.
Residential Proximity to Methyl Bromide Use and Birth Outcomes in an Agricultural Population in California
Authors: Alison Gemmill, Robert B. Gunier, Asa Bradman, Brenda Eskenazi, Kim G. Harley
Journal: Environmental Health Perspectives (2013)

Background: Methyl bromide, a fungicide often used in strawberry cultivation, is of concern for residents who live near agricultural applications because of its toxicity and potential for drift. Little is known about the effects of methyl bromide exposure during pregnancy.Objective: We investigated the relationship between residential proximity to methyl bromide use and birth outcomes.Methods: Participants were from the CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas) study (n = 442), a longitudinal cohort study examining the health effects of environmental exposures on pregnant women and their children in an agricultural community in northern California. Using data from the California Pesticide Use Reporting system, we employed a geographic information system to estimate the amount of methyl bromide applied within 5 km of a woman's residence during pregnancy. Multiple linear regression models were used to estimate associations between trimester-specific proximity to use and birth weight, length, head circumference, and gestational age.Results: High methyl bromide use (vs. no use) within 5 km of the home during the second trimester was negatively associated with birth weight (β = –113.1 g; CI: –218.1, –8.1), birth length (β = –0.85 cm; CI: –1.44, –0.27), and head circumference (β = –0.33 cm; CI: –0.67, 0.01). These outcomes were also associated with moderate methyl bromide use during the second trimester. Negative associations with fetal growth parameters were stronger when larger (5 km and 8 km) versus smaller (1 km and 3 km) buffer zones were used to estimate exposure.Conclusions: Residential proximity to methyl bromide use during the second trimester was associated with markers of restricted fetal growth in our study.
Mandatory Continuing Education
Authors: MARTIN ALTCHECK
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I entirely agree with the article "Help Stamp Out Mandatory Continuing Education" (233:797, 1975). I practice solo in a small community, and except for attending the Annual Meeting of the American Academy of Orthopedic Surgeons, I do not have more than cursory communication with other orthopedic surgeons during the course of the year. I do no teaching and have not been inside a medical school since I graduated in 1949. I just took the self-assessment examination given by the American Academy of Orthopedic Surgeons and scored in the 99th percentile. I keep up to date by reading and also publish a few articles of my own. The time it takes to travel to and from conventions or meetings, and the wasted time at meetings, can be much more suitably utilized in your own library. Attending fully what I believe is the one best meeting of the year
Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma
Authors: Zhou Luan, Ying He, Mohamed Alattar, Zhishui Chen, Fan He
Journal: Molecular Cancer (2014)

Robust ERK1/2 activity, which frequently results from KRAS mutation, invariably occurs in pancreatic ductal adenocarcinoma (PDAC). However, direct interference of KRAS signaling has not led to clinically successful drugs. Correct localization of RAF is regulated by the scaffold protein prohibitin (PHB) that ensures the spatial organization between RAS and RAF in plasma membranes, thus leading to activation of downstream effectors. PHB expression was analyzed in human pancreatic cancer cell lines, normal pancreas, and PDAC tissue. Furthermore, genetic ablation or pharmacological inhibition of PHB was performed to determine its role in growth, migration, and signaling of pancreatic cancer cells in vitro and in vivo. The level of PHB expression was crucial for maintenance of oncogenic ERK-driven pancreatic tumorigenesis. Additionally, rocaglamide (RocA), a small molecular inhibitor, selectively bound to PHB with nanomolar affinity to disrupt the PHB-CRAF interaction by altering its localization to the plasma membrane. Consequently, there was an impairment of oncogenic RAS-ERK signaling, thereby blocking in vitro and in vivo growth and metastasis of pancreatic cancer cells that were addicted to RAS-ERK signaling. More importantly, RocA treatment resulted in a significant increase of the lifespan of tumor-bearing mice without any detectable toxicity. Blockade of the PHB scaffold-CRAF kinase interaction, which is distinct from direct kinase inhibition, may be a new therapeutic strategy to target oncogenic ERK-driven pancreatic cancer.
Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children
Authors: Sandy R. Durrani, Daniel J. Montville, Allison S. Pratt, Sanjukta Sahu, Mark K. DeVries, Victoria Rajamanickam, Ronald E. Gangnon, Michelle A. Gill, James E. Gern, Robert F. Lemanske, Daniel J. Jackson
Journal: Journal of Allergy and Clinical Immunology (2012)
Changes in blood lipids and blood pressure during adolescence.
Authors: T J Orchard, M Rodgers, A J Hedley, J R Mitchell
Journal: BMJ (1980)

A total of 625 adolescents from three general practices participated in a cross-sectional study of cardiovascular disease risk factors. The girls had higher serum total and high density lipoprotein (HDL) cholesterol concentrations than the boys, while the boys had higher serum triglyceride concentrations. Smoking (equally prevalent in both sexes) was associated with lower HDL cholesterol concentrations, particularly in boys, while in girls use of oral contraceptives was associated with higher total cholesterol and lower HDL cholesterol concentrations showed striking associations with age, height, and sexual maturation in boys, but not in girls. Triglyceride concentrations were associated with age in boys. Systolic blood pressure and serum urate concentrations were higher in boys and rose steeply with age, but no age association was seen for urate concentrations or systolic blood pressure in girls or for diastolic pressures in either sex. Girls, however, had higher diastolic pressures. There was a strong association between urate concentration and the other cardiovascular disease risk factors, especially HDL cholesterol. Adolescence is associated with considerable changes in cardiovascular disease risk factors, and there are striking sex differences in these changes.
High blood pressure: some answers, new questions, continuing challenges
Authors: C. Lenfant
Journal: JAMA (1996)

Hypertension remains a large public health problem in the United States. 1 Nearly 50 million Americans have elevated blood pressure warranting some type of treatment or monitoring. 2 It is also prevalent in most populations around the world. In addition, this common condition is strongly related causally to important chronic cardiovascular and renal diseases. 3 Two articles in this theme issue ofThe Journalsummarize and expand our knowledge of these risk relationships. 4,5   Hypertension can be treated successfully, and several articles in this issue suggest additional approaches to management. 6,7 However, there is ample evidence that current approaches are less than optimal. Because hypertension is a chronic, usually noncurable disorder, the ultimate aim must be sufficient understanding of the etiology to prevent its occurrence. The papers by Obarzanek et al, 8 Staessen et al, 9 and Midgley et al 10 attempt to direct or redirect such efforts. Cowley and