tbuckley/cabot-search huggingface dataset:
255. Embryonic Stem Cell-Mediated Regenerative Therapy for Duchenne Muscular Dystrophy
Authors: Shiro Ozasa, Shigemi Kimura, Makoto Matsukura, Kaori Ito, Makoto Ikezawa, Hiroe Kawano, Teruhisa Miike, Kenichi Yamamura, Kimi Araki, Kuniya Abe, Hitoshi Niwa
Journal: Molecular Therapy (2005)

Introduction: Duchenne muscular dystrophy (DMD) is a severe muscle degenerative disorder caused by mutations in the dystrophin gene. Embryonic stem cell (ES cell) transplantation is one of the more promising therapies because ES cells are available in large quantities and can serve to systemically restore affected muscles of DMD patients. Although ES cells have shown to be capable of differentiating into various tissues and cell types, it has been difficult to induce differentiation of ES cells specifically into muscle fibers only. We are proposing a method to overcome this impediment by establishing genetically engineered ES cells which harbor a tetracycline-regulated expression vector encoding the myogenic transcriptional factor MyoD.
Comparative Nephrotoxicity of Aspirin and Phenacetin Derivatives
Authors: I. C. Calder, C. C. Funder, C. R. Green, K. N. Ham, J. D. Tange
Journal: BMJ (1971)

Both aspirin and phenacetin derivatives were shown to be nephrotoxic when administered to rats as a single intravenous injection. Phenacetin derivatives tended to produce more severe renal damage and to be nephrotoxic in smaller doses than aspirin derivatives. With the exception of a single derivative, the renal lesions were confined to the proximal convoluted tubule, even after administration of compounds which under other conditions have induced renal papillary necrosis.
Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma
Authors: Dunja Schneider, Marcus Dühren-von Minden, Alabbas Alkhatib, Corinna Setz, Cornelis A. M. van Bergen, Marco Benkißer-Petersen, Isabel Wilhelm, Sarah Villringer, Sergey Krysov, Graham Packham, Katja Zirlik, Winfried Römer, Christian Buske, Freda K. Stevenson, Hendrik Veelken, Hassan Jumaa
Journal: Blood (2015)
Shamans, Mystics and Doctors: A Psychological Inquiry Into India and Its Healing Traditions
Authors: Thomas H. Lewis
Journal: JAMA (1984)

This book, published by the Unitarian Universalist Association of Boston, is the result of a three-year study of traditional mental health and healing systems in India. The work was supported by the Homi Bhabha Fellowship. The fortunate reader is carried into a vivid and detailed experience of Islamic<i>uranic</i>soul knowledge and soul force, Hindu temple healing at Balaji, Dravidian shamans, Tibetan demonology, the devotional mysticism of the sect of Radha Soami Satsang of Beas, Tantra texts and healing, the cult of Primal Power Mata Nirmala Devi, Who Is God, and of Ayurveda and an Ayurvedic mental hospital at Jharsetli. Each system is well described from a structural-theoretical standpoint, and from the actual experience of patients, practitioners, and observers. Each system is then examined in the overall Indian medical context, and in Western (Christian, psychoanalytic, and medical) idiom. Most readers will find this journey to India fascinating and Sudhir Kakar
A Profession in Distress
Authors: John Lister
Journal: New England Journal of Medicine (1976)

At the time of writing the medical profession in Britain is in more serious conflict with the government than ever before. The 19,000 junior doctors in the hospital service are working a strict 40-hour week, and the consultants and specialists have been advised by the British Medical Association to treat emergency cases only while the Hospital Consultants and Specialists Association is calling for mass resignations from the National Health Service (NHS).Two separate issues are involved. The junior doctors who have been negotiating the terms of a new contract with the Department of Health for more than a year have . . .
Cushing's Disease in a Patient With an Ectopic Pituitary Adenoma
Authors: Huldrick Kammer
Journal: JAMA (1981)

THE OCCURRENCE of pituitary tissue in an ectopic location but not in continuity with intrasellar pituitary tissue has been previously reported.<sup>1-7</sup>However, pituitary dysfunction in such patients is uncommon.<sup>1-3</sup>We describe here a patient with pituitary-dependent Cushing's syndrome who had a chromophobe adenoma located in the sphenoid sinus. <h3>Report of a Case</h3> A 51-year-old woman was admitted to our medical center in 1976 for evaluation of persistent microscopic hematuria. This was first noted two years earlier on routine urinalysis and on repeated examinations. Findings from renal function tests, intravenous pyelogram, and cystoscopy were considered normal. She was known to have arterial hypertension for at least five years. Her blood pressure (BP) responded favorably to medication until three months before admission, when it became difficult to control. During this period the patient noted increasing weakness, malaise, puffiness of her face, facial hair, increasing skin pigmentation, and weight gain. Her
Is Arrhythmia Detection by Automatic External Defibrillator Accurate for Children?
Authors: Frank Cecchin, Dawn B. Jorgenson, Charles I. Berul, James C. Perry, A. Andrew Zimmerman, Brian W. Duncan, Flavian M. Lupinetti, David Snyder, Thomas D. Lyster, Geoffrey L. Rosenthal, Brett Cross, Dianne L. Atkins
Journal: Circulation (2001)

Background —Use of automatic external defibrillators (AEDs) in children aged &lt;8 years is not recommended. The purpose of this study was to develop an ECG database of shockable and nonshockable rhythms from a broad age range of pediatric patients and to test the accuracy of the Agilent Heartstream FR2 Patient Analysis System for sensitivity and specificity. Methods and Results —Children aged ≤12 years who either developed arrhythmias or were at risk for developing arrhythmias were studied. Two sources were used for the database: children whose rhythms were recorded prospectively via a modified AED and children who had arrhythmias captured on paper and digitized for subsequent analysis. The rhythms were divided into 5-second strips, classified by 3 reviewers, and then assessed by the AED analysis algorithm. A total of 696 five-second rhythm strips from 191 children (81 female and 110 male) aged 1 day to 12 years (median 3.0 years) were analyzed. There was 100% specificity for nonshockable rhythms. Sensitivity for ventricular fibrillation was 96%. Conclusions —There was excellent AED rhythm analysis sensitivity and specificity in all age groups for ventricular fibrillation and nonshockable rhythms. The high specificity and sensitivity indicate that there is a very low risk of an inappropriate shock and that the AED correctly identifies shockable rhythms, making the algorithm both safe and effective for children.
Treatment of presumed and proven acute rejection following six months of lung transplant survival.
Authors: S Kesten, A Maidenberg, T Winton, J Maurer
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The gold standard for the diagnosis and subsequent treatment of acute rejection of lung allografts is the demonstration of rejection on transbronchial biopsy specimens. However, treatment may be initiated in the case of a compatible clinical scenario in the absence of definitive histologic documentation. In the Toronto Lung Transplant Program, we have treated patients with a decline in FEV1 and no evidence of infection with augmented systemic steroids for a presumed diagnosis of rejection. We retrospectively reviewed all episodes of acute rejection that occurred beyond 6 mo after transplant where treatment with augmented steroids had been initiated. A total of 72 treatments with augmented steroids were initiated in 45 patients who underwent 47 transplant procedures. FEV1 showed at least a 10% improvement following steroids in 14 of 72 (19%). FEV1 continued to decline by at least 10% in 32 of 72 (44%). Changes in FEV1 between +10 and -10% occurred in 26 of 72 (36%); of those episodes, 19 showed a decline of < 10%. Histologic evidence of at least grade II rejection was documented in only 16 cases. In those cases, FEV1 improved by at least 10% in 7 of 16 (44%), whereas it declined by at least 10% in 4 of 16 (25%). Spirometric evidence of bronchiolitis obliterans syndrome developed within 3 mo of the treated rejection episode in at least 20 of 47 transplants (43%). We conclude that treatment with augmented systemic steroids for presumed and histologically proven acute rejection beyond 6 mo after transplant is often ineffective in improving spirometry.
P17.83 * OUTCOMES OF RECURRENT GLIOBLASTOMA PATIENTS TREATED WITH BEVACIZUMAB AT A TERTIARY CARE CENTER
Authors: G. H. J. Stevens, S. Sakruti, S. Griffin, D. Peereboom, M. S. Ahluwalia
Journal: Neuro-Oncology (2014)

BACKGROUND: Bevacizumab is FDA approved for use in recurrent glioblastoma (rGBM). There is limited information on outcomes of rGBM treated with bevacizumab at tertiary care hospitals. We evaluated the progression-free survival (PFS) and overall survival (OS) in rGBM patients treated with bevacizumab at our center. We also examined the outcomes of patients with rGBM treated with bevacizumab in first recurrence, second recurrence or third or greater recurrence to see if there was a PFS or OS survival difference (three groups). METHODS: With IRB approval, the Cleveland Clinic Brain Tumor database was used to examine 690 rGBM patient charts (2003 to 2013). The patients that received bevacizumab for rGBM were included for this analysis. Progression-free survival and OS was calculated using Kaplan-Meier analysis and the Renyi (supremum log-rank) test to formally compare the difference in overall and PFS between the three groups. All analyses were completed in R version 3.0.1. RESULTS: One hundred and fifty patients received bevacizumab for rGBM. The median age 56 years (range: 24-83). Median KPS prior to initiation of bevacizumab treatment was 80 (range: 40-100). Twenty-eight patients had multifocal and 122 had unifocal disease at time of starting bevacizumab therapy. The median number of comorbidities at diagnosis was1 (range: 0-4). Seventy five patients (50%) received bevacizumab at first recurrence, 50 patients (33%) started bevacizumab at second recurrence, and 25 patients (17%) were treated with bevacizumab at third or later recurrences. Median OS from start of bevacizumab was 12.2 months (95% CI: 10.0, 14.3) and median PFS was 8.3 months (95% CI: 6.2, 10.2). Stratified by recurrence and initiation of bevacizumab, median PFS was 7.1 months (95% CI: 5.9, 10.1) for the first recurrence, 9.9 months (95% CI: 6.3, 25.2) for second recurrence, and 9.4 months (95% CI: 3.8, 16.8) for the third recurrence (p = 0.09). Median OS was 11.7 months (95% CI: 10.3, 14.3) for first recurrence, 10.0 months (95% CI: 8.1, 39.3) for second recurrence, and 13.9 months (95% CI: 8.2, 18.4) for the third or later recurrence (p = 0.26). CONCLUSIONS: The benefit seen with bevacizumab in our cohort is consistent with that reported in other studies. There was no significant difference in median OS or PFS in the patients with rGBM groups treated with bevacizumab in first, second or third or later recurrence. One hypothesis is that patients who need bevacizumab at first recurrence possibly have larger tumors or a more rapid disease trajectory than those who receive it at a later recurrence.
INJURY TO THE HEAD REGION IN ELITE MALE GAELIC FOOTBALL AND HURLING: 2007–2012
Authors: C Blake, M John, G Conor, E O'Malley
Journal: British Journal of Sports Medicine (2014)

Background Gaelic football and hurling are national sports of Ireland. The Gaelic Athletic Association has supported the development of an injury database as a platform for injury prevention. Objective To report on epidemiology of head injury, in teams registered to the National Injury Database (2007–2012). Design Prospective injury surveillance. Setting Elite level teams. Participants Male players selected for representative county teams were enrolled, with consent, to the database. Identities were concealed and data collected from January 1st each year until elimination from the inter-county competition. Assessment of risk factors Injury incidence was measured prospectively. Main outcome measures A time-loss injury definition was used, conforming to international consensus definitions. The team doctor or Chartered physiotherapist recorded date, type and circumstances of injury, as well as date of return to partial or full fitness. Injury incidence was expressed as rate per 1000 hours participation in match-play and training. Injury proportions were calculated. Results Thirty-five football and 28 hurling squads participated. There were 1188 football players and 914 hurlers in total over the 6 years. Injuries to the head region constituted 3.0% of football injuries and 2.4% of hurling injuries. The head injury incidence rate was 0.26 per 1000 hours of football and 0.19 per 1000 hours of hurling overall. Concussion was diagnosed in 0.8% football and 0.8% hurling injuries. Fractures to the nose constituted 0.7% football injuries and 0.3% hurling injuries. Fractured mandible was reported in football (0.2% injuries) and fractured maxilla/orbit in hurling (0.08%). Perforated eardrum was reported in both football (0.08%) and hurling (0.09%). Lacerations and contusions accounted for 0.9% injuries for football and 0.8% for hurling. There was an additional retinal bleed (0.09%) and dental injury (0.09%) in hurling. Conclusions The results provide reference data for head injury in these sports, against which injury prevention methods can be evaluated.
EFFECTS OF PIOGLITAZONE ON PLATELET P2Y12 MEDIATED SIGNALING IN CLOPIDOGREL TREATED PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Siva Suryadevara, Masafumi Ueno, Antonio Tello-Montoliu, Jose Luis Ferreiro, Bhaloo Desai, Fabiana Rollini, Lyndon Box, Martin Zenni, Luis Guzman, Theodore Bass, Dominick Angiolillo
Journal: Journal of the American College of Cardiology (2012)
Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells
Authors: Martin Guimond, Rachelle G Veenstra, David J Grindler, Hua Zhang, Yongzhi Cui, Ryan D Murphy, Su Young Kim, Risu Na, Lothar Hennighausen, Sema Kurtulus, Batu Erman, Polly Matzinger, Melinda S Merchant, Crystal L Mackall
Journal: Nature Immunology (2009)
GW25-e3558 Prevention of Angiotensin II-induced Cardiomyopathy by Sulforaphane-activated Nrf2 Partially via AKT/GSK-3β/Fyn Pathway
Authors: Jiang Xin, Ying Xin, Yang Bai, Shanshan Zhou, Lu Cai
Journal: Journal of the American College of Cardiology (2014)
Hats Off to Dr Huxtable
Authors: Roselyn Payne Epps
Journal: JAMA (1985)

Last season, those who happened to be home by 8 PM Eastern Standard Time on Thursday evenings, and remembered to turn on their television sets, tuned in to a special treat, Heathcliff Huxtable, MD, a.k.a. Bill Cosby, EdD. For those who haven't heard of our new colleague who has hung out his shingle, he's the OB/GYN specialist who, along with his attorney wife and their five children (ages preschool through adolescence), millions of Americans visit each week. In fact, so many tune him in that the show has topped the ratings for months. Top ratings weren't earned just because the Cosby show is amusing and entertaining—Cosby is almost always both. Rather, the audience is tuning in because the show portrays a wholesome family, living in today's world, facing today's problems and pleasures, with love, warmth, and lots of common sense. That segment of the public, whose image has been fashioned
The Opprobrium of Big Tobacco
Authors: Claude A. Piantadosi, Raquel R. Bartz, Martha S. Carraway, Andrew J. Ghio, Timothy J. McMahon, David M. Murdoch, Victor L. Roggli, Scott L. Shofer, Robert M. Tighe, Karen E. Welty-Wolf, Stephen L. Young
Journal: American Journal of Respiratory and Critical Care Medicine (2012)
Abstract 3363: Iron deficiency suppress EMT through downregulation of N-cadherin in esophageal cancer
Authors: Seishi Nishitani, Kazuhiro Noma, Shinichiro Watanabe, Teppei Onishi, Toshiaki Ohara, Yasuko Tomono, Yuuri Hashimoto, Hiroshi Tazawa, Toshiyoshi Fujiwara
Journal: Cancer Research (2011)

Abstract [Introduction] Epithelial-Mesenchymal-transition(EMT) plays a great roles in cancer metastasis and invasion.Mecanism of EMT remains controversial, but it is recognized that some protein change their expression, including E-cadherin and N-cadherin.It is reported that downregulation of N-cadherin reduce cancer metastasis and invasiveness. Iron metabolism and its relationship with cancer cell were studied for a long time. Iron overload is known to induce some kinds of cancer, which suggests that prevention of iron overload is a therapeutic strategy of cancer prevention. Iron deficiency is also known to suppress the tumor growth in vivo study. But the efficacy is not superior to the ordinary chemotherapy, it's not a standard therapeutic strategy of cancer. Recently, it is reported that iro metabolism is essential for EMT, and iron defficiency downregulate EMT change. In this study, we demonstrated that iron deficiency downregulate the expression of the EMT protein, N-cadherin, and suppressed the ability of metastasis and invasiveness. This result suggests that Iron controlled treatment can be novel therapeutic agent for cancer under EMT. [Matherials and Methods] TE-1,TE-4,TE-8 and TE-10 esophageal squamous cell carcinoma, OE19 and OE33 esophageal adenocarcinoma cell lines were used in this study. In vitro study, cell viability was determined by XTT assay. Iron chelator deferasirox was prepared in vitro study to make iron deficient condition. To determine that iron deficiency suppresses EMT and invasiveness of cancer cell line, western blotting analysis, the three-dimensional spheroid model analysis and migration assay were done. In vivo study, Normal diet and Iron deficient diet were fed for 3 weeks before implantation of TE-4 cells in athymic male nude mice(n=8/group). After implantation, each diet was fed continually. [Results]Deferasirox reduces proliferation of all cell line in a concentration manner. According to western blotting analysis, deferasirox induces reduction of N-cadherin protein in TE-4 and TE-10 cell lines. N-cadherin downregulation declines invasiveness of TE-4 and TE-10 cell lines in the three-dimensional spheroid model analysis and migration assay. In vivo study, tumor growth was suppressed in iron deficient diet group (tumor volume: normal diet vs iron deficient diet = 30.7±1.1 vs 10.9±2.2) [Conclusion]Iron controlled treatment can be novel therapeutic agent for invasiveness of cancer under EMT. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3363. doi:10.1158/1538-7445.AM2011-3363
WHO definition of health remains fit for purpose
Authors: D. M. Lewis
Journal: BMJ (2011)

<h3>Abstract</h3> <h3>Background</h3> After lock-down during the first wave of the COVID-19 pandemic, higher education institutions globally struggled to balance the need for infection control and educational requirements as they prepared to reopen. A particularly difficult choice was whether to offer for in-person or online teaching, since there was little or no empirical research to inform this decision. Norwegian universities and university colleges opted for a hybrid model when they reopened for the autumn semester, with some students offered more in-person teaching than others. This gave us an opportunity to study the association between different teaching modalities and COVID-19 risk, quality of life (subjective well-being), and teaching satisfaction. <h3>Methods</h3> We conducted a prospective, observational cohort study among students in higher education institutions in Norway. Participants were surveyed biweekly from September to December in 2020. <h3>Findings</h3> 26 754 students from 14 higher education institutions provided data to our analyses. Our best estimate for the association between two weeks of in-person teaching and COVID-19 risk was −22% (95% CI −77% to 33%), compared to online teaching. Quality of life was positively associated with in-person teaching (3% relative risk difference; 95% CI 2% to 4%), as was teaching satisfaction (10%; 95% CI 8% to 11%). <h3>Interpretation</h3> The association between COVID-19 infection and teaching modality was highly uncertain. Shifting from in-person to online teaching seems to have a negative impact on the well-being of students in higher education. <h3>Funding</h3> None.
Human Mast Cells and Nuocytes Activate Gene Expression and Mucus Secretion in Primary Mucociliary Differentiated Human Bronchial Epithelial Cells Via IL-13
Authors: Deepti Nagarkar, Vladimir Corrozzi, David Choy, Alex Abbas, Rajita Pappu, Joseph R. Arron
Journal: Journal of Allergy and Clinical Immunology (2013)
MeSH terms must be used in Medline searches
Authors: M. Clarke, L. Greaves, S. James
Journal: BMJ (1997)

Joel Ray and Marian Vermeulen highlight the existence of misspellings of medical terms in Medline.1 A problem also exists with methodological terms. Perhaps the most important of these for someone interested in patient care or the preparation of a systematic review is the truncated free text “random*,” which might identify reports of randomised trials. We searched Medline for some common misspellings of random to identify how often they occur and whether the retrieved records could have been …