The Use of Ampicillin in Acute Pancreatitis
Authors: ROBERT M. CRAIG
Journal: Annals of Internal Medicine (1975)

Letters1 December 1975The Use of Ampicillin in Acute PancreatitisROBERT M. CRAIG, M.D., ERL DORDAL, M.D., F.A.C.P., LEWIS MYLES, M.S., R.PH.ROBERT M. CRAIG, M.D.Search for more papers by this author, ERL DORDAL, M.D., F.A.C.P.Search for more papers by this author, LEWIS MYLES, M.S., R.PH.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-6-831 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe suggestion that bacteria may be involved pathophysiologically in acute pancreatitis has been supported by the efficacy of antibiotics in diminishing the mortality of experimental pancreatitis (1), and the possibly lower incidence of pancreatic abscesses since the use of antibiotics in pancreatitis (2). However, a recent retrospective review showed that the incidence of infectious complications in acute pancreatitis was similar in those given and not given prophylactic antibiotics (3). As there have been heretofore no published controlled studies, our investigation was designed to help answer this question, by comparing prophylactic ampicillin with placebo in the management of acute pancreatitis.All...References1. PERSKYSCHWEINBERGJACOB LFS: Aureomycin in experimental acute pancreatitis of dogs. Surgery 30:652-656, 1951 MedlineGoogle Scholar2. EVANS F: Pancreatic abscess. Am J Surg 117:537, 1969 CrossrefMedlineGoogle Scholar3. KODESCHDU PONT RH: Infectious complications of acute pancreatitis. Surg Gynecol Obstet 136:763-768, 1973 MedlineGoogle Scholar4. SWITZ D: Acute alcoholic pancreatitis: effect of clinical presentation and therapies on outcome at a V.A. Hospital (abstract). Ann Intern Med 78:816-817, 1973 LinkGoogle Scholar5. TRAPNELLRIGBYTALBOT JCC: A controlled trial of Trasylol in the treatment of acute pancreatitis. Br J Surg 61:177-182, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Research Hospital; and Gastroenterology Department Northwestern University School of Medicine Chicago, Illinois 60611 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntibiotic therapy in acute pancreatitis: From global overuse to evidence based recommendationsEarly management of acute pancreatitis: A review of the best evidenceJapanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015Is antibiotic prophylaxis beneficial in acute pancreatitis: first updateAntibiotic TherapyPancreatic InfectionAntibiotics in severe acute pancreatitisNutrition, Inflammation, and Acute PancreatitisInfectious Complications of Acute PancreatitisManagement of acute pancreatitis and complicationsAcute Pancreatitis: Should We Use Antibiotics?Systematic review and meta-analysis of antibiotic prophylaxis in severe acute pancreatitisAntibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitisFundamental and intensive care of acute pancreatitisThe Role of Antibiotics in the Management of Patients with Acute Necrotizing PancreatitisPancreatic InfectionSummarized Review of the Clinical Guideline of Acute Pancreatitis (Third Edition): Changes in the new assessment of severity and diagnostic criteriaPharmacotherapy for acute pancreatitisNecrotizing pancreatitis and antibiotic prophylaxis. To use or not to use . . . that is the questionProphylactic antibiotic treatment in acute necrotizing pancreatitis: Results from a meta-analysisProphylactic Antibiotics Cannot Reduce Infected Pancreatic Necrosis and Mortality in Acute Necrotizing Pancreatitis: Evidence From a Meta-Analysis of Randomized Controlled TrialsEarly Antibiotic Treatment for Severe Acute Necrotizing PancreatitisEffect of early and late antibiotic treatment in experimental acute pancreatitis in ratsHistory and Evolution of the Management of Acute PancreatitisAntibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitisMeta-analysis of prophylactic antibiotic use in acute necrotizing pancreatitisAntibiotic prophylaxis of pancreatic infection in patients with necrotizing pancreatitis: Rationale, evidence, and recommendationsJPN Guidelines for the management of acute pancreatitis: medical management of acute pancreatitisThe Role of Antibiotic Prophylaxis in the Treatment of Acute PancreatitisDo antibiotics have a role in the management of severe pancreatitis?Pharmacological Prevention and Treatment of Acute Pancreatitis: Where Are We Now?Role of Prophylactic Antibiotic Administration in Severe Acute Pancreatitis: A Meta-AnalysisPancreatic infection complicating acute pancreatitisAntimicrobial treatment of pancreatic infection in catsManagement of the critically ill patient with severe acute pancreatitisInitial Management of Acute Pancreatitis: Critical Issues During the First 72 HoursDiscussion on prophylactic antibiotic treatment in patients with predicted severe pancreatitis: A placebo-controlled, double-blind trialInfectious complications of pancreatitis: Diagnosis and managementAntibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitisAkute PankreatitisPancreatitisAntibiotic prophylaxis in the initial management of severe acute pancreatitis¿Antibioterapia profiláctica en la pancreatitis aguda grave?Acute and chronic pancreatitisInfection prevention in necrotizing pancreatitis: an old challenge with new perspectivesUPDATE ON THE MANAGEMENT OF ACUTE SEVERE PANCREATITISProphylactic antibiotics and pancreatic necrosisProphylactic Antibiotic Administration Reduces Sepsis and Mortality in Acute Necrotizing Pancreatitis: A Meta-AnalysisBacterial Infection of Pancreatic Necrosis: Role of Bacterial Translocation, Impact of Antibiotic TreatmentOptimising Outcomes in Acute PancreatitisManagement of necrotizing pancreatitisPreventing pancreatic infection in acute pancreatitisReview article: the treatment of acute biliary pancreatitisTHE ROLE OF ANTIBIOTIC PROPHYLAXIS IN THE TREATMENT OF ACUTE PANCREATITISNONSURGICAL MANAGEMENT OF ACUTE PANCREATITISProphylactic Antibiotics for Severe Acute Pancreatitis: The Beginning of an EraProphylactic Antibiotics and Selective Digestive Decontamination in Severe Acute PancreatitisAcute Pancreatitis: Bacterial Translocation and Pancreatic InfectionsAntibiotics in severe pancreatitis: the current statusControlled clinical trial of pefloxacin versus imipenem in severe acute pancreatitisAntibiotic Prophylaxis in Acute Necrotizing PancreatitisAcute pancreatitis: Nonsurgical managementA critical review of antibiotic prophylaxis in severe acute pancreatitisThrombotic thrombocytopenic purpura/hemolytic uremic syndrome secondary to pancreatitisAcute Pancreatitis: Medical ManagementPenetration of ciprofloxacin into the human pancreasAcute PancreatitisAcute pancreatitisPenetration of ceftazidime into human pancreasGabexate mesilate in human acute pancreatitisBacterial Infection and the Role of Fine Needle AspirationHuman pancreatic tissue concentration of bactericidal antibioticsAntibiotics Secretion into Pancreatic FluidTreatment of pancreatitisThe penetration of antibiotics into human pancreasEffect of pancreatitis on moxalactam excretion in pancreatic fluids of dogs and manAcute PancreatitisKonservative Therapie der akuten PankreatitisAcute Pancreatitis: Standards of Conservative TreatmentPrinciples of Intensive Care of Patients with Acute PancreatitisBacterial contamination of pancreatic necrosisBlood-pancreatic juice barrier to antibiotic excretionResults of surgical treatment of necrotizing pancreatitisSecretion of β-lactam antibiotics in pure human pancreatic juiceAcute PancreatitisMICHAEL C. GEOKAS, M.D.. Ph.D., HAROLD A. BALTAXE, M.D., PETER A. BANKS, M.D., JOSEPH SILVA Jr., M.D., CHARLES F. FREY, M.D.Controlled Clinical Trial of Peritoneal Lavage for the Treatment of Severe Acute PancreatitisResults of mobilization and drainage of the pancreas for acute pancreatitisAcute and chronic pancreatitisAllgemeine konservative TherapieIndikationen und Verfahrenswahl aus internistischer SichtCurrent Status of Diagnosis and Conservative Treatment of Acute PancreatitisIntensive medical treatment of severe acute pancreatitisInvited commentaryAkute und akut-rezidivierende PankreatitisSevere Acute PancreatitisEffect of pancreatitis on ampicillin excretion in pancreatic fluids of dogsAmpicillin Concentrations in Pancreatic Fluid Bile Obtained at Endoscopic Retrograde Cholangiopancreatography (ERCP)Treatment of Acute PancreatitisDrug Therapy of Acute PancreatitisPancreatitis: Pancreatic Pseudocysts and their Complications 1 December 1975Volume 83, Issue 6Page: 831-832KeywordsAbscessesAcute pancreatitisAntibioticsBacteriaMortalityPancreatitis Issue Published: 1 December 1975 PDF downloadLoading ...