Lymphoblastic-like Leukemic Transformation of Polycythemia Vera
Authors: Ronald Hoffman, Solomon Estren, Samuel Kopel, Stanley M. Marks, Ronald P. McCAFFREY
Journal: Annals of Internal Medicine (1978)

Brief Reports1 July 1978Lymphoblastic-like Leukemic Transformation of Polycythemia VeraRONALD HOFFMAN, M.D., SOLOMON ESTREN, M.D., SAMUEL KOPEL, M.D., STANLEY M. MARKS, M.D., RONALD P. McCAFFREY, M.D.RONALD HOFFMAN, M.D.Search for more papers by this author, SOLOMON ESTREN, M.D.Search for more papers by this author, SAMUEL KOPEL, M.D.Search for more papers by this author, STANLEY M. MARKS, M.D.Search for more papers by this author, RONALD P. McCAFFREY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-1-71 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPolycythemia vera terminates in acute leukemia in 0 to 30% of cases, depending on the series cited (1). The nature of this leukemic transformation has not been well characterized but is generally considered to be a variant of acute myeloblastic leukemia. We present here the case of a patient with polycythemia vera who underwent a leukemic transformation. The leukemic blast cells from this patient possessed the morphologic and biochemical features usually associated with blast cells of patients with acute lymphoblastic leukemia.In 1971, a 77-year-old white man underwent a prostatectomy for benign prostatic hypertrophy. The procedure was complicated by excessive...References1. LANDOW S: Acute leukemia in polycythemia vera. Semin Hematol 13:33-48, 1976 MedlineGoogle Scholar2 WASSERMAN L: The management of polycythaemia vera. Br J Haematol 21:371-376, 1971 CrossrefMedlineGoogle Scholar3. MCCAFFREYHARRISONKUNGPARKMANSILVERSTONEBALTIMORE RTPRAD: Terminal deoxynucleotidyl transferase in normal and neoplastic hematopoietic cells, in Modern Trends in Human Leukemia. II, edited by NETH RJ, GALLO RC, MANNWEILER K, et al. Munich, J. F. Lehmans Verlag, 1976, pp. 503-513 CrossrefGoogle Scholar4. JANOSSYROBERTSGREAVES GMM: Target cell in chronic myeloid leukaemia and its relationship to acute lymphoid leukaemia. Lancet 2:1058-1060, 1976 CrossrefMedlineGoogle Scholar5. MARKSBALTIMOREMCCAFFREY SDR: Terminal transferase as a predictor of initial responsiveness to vincristine-prednisone in blastic chronic myelogenous leukemia. N Engl J Med 298:812-814, 1978 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RONALD HOFFMAN, M.D.; SOLOMON ESTREN, M.D.; SAMUEL KOPEL, M.D.; STANLEY M. MARKS, M.D.; RONALD P. 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A case reportClonal and Stem Cell Origin of Blood Cell NeoplasmsAcute myeloblastic leukemia developing in patients with mediastinal lymphoblastic lymphomaCorrelation of Biochemical and Immunological Markers with Conventional Morphology and Clinical Features in 120 Patients with Malignant LymphomasClinical Significance of TdT, Cell Surface Markers and CFU-C in 297 Patients with Hematopoietic NeoplasiasClonal Diseases of the Myeloid Stem Cell Systems 1 July 1978Volume 89, Issue 1Page: 71-71KeywordsAcute myeloid leukemiaBenign prostatic hyperplasiaCellsPolycythemia veraPrecursor cellsProstatectomy ePublished: 1 December 2008 Issue Published: 1 July 1978 PDF downloadLoading ...