Organic Acids in Ethylene Glycol Intoxication
Authors: DAG JACOBSEN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 November 1986Organic Acids in Ethylene Glycol IntoxicationDAG JACOBSEN, M.D., Ph.D.DAG JACOBSEN, M.D., Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-5-799_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Gabow and coworkers (1), in their recent article, identify glycolate and lactate as the predominant acids causing the metabolic acidosis of ethylene glycol poisoning. They also show that hemodialysis with a bicarbonate dialysate is an efficient method for removal of glycolate and resolution of the acidemia. While both glycolate's contribution to the ethylene-glycol-induced acidosis and its dialysability have been described previously (2, 3), we question the role of lactate increases in this syndrome.Experimental studies with rats, dogs, and monkeys as well as the evaluation of six intoxicated patients have not documented substantial lactate increases, and it...References1. GABOWCLAYSULLIVANLEPOFF PKJR. Organic acids in ethylene glycol intoxication. Ann Intern Med. 1986;105:16-20. LinkGoogle Scholar2. JACOBSENMCMARTIN DK. Methanol and ethylene glycol poisonings: mechanism of toxicity, clinical course, diagnosis and treatment. Med Toxicol. 1986. (In press). CrossrefMedlineGoogle Scholar3. JACOBSENOVREBOOSTBORGSEJERSTED DSJO. Glycolate causes the acidosis in ethylene glycol poisoning and is effectively removed by hemodialysis. Acta Med Scand. 1984;216:409-16. CrossrefMedlineGoogle Scholar4. JACOBSENAKESSONSHEFTER DIE. Urinary calcium oxalate monohydrate crystals in ethylene glycol poisoning. Scand J Clin Lab Invest. 1982;42:231-4. CrossrefMedlineGoogle Scholar5. JACOBSENBREDESENEIDEOSTBORG DJIJ. Anion and osmolal gaps in the diagnosis of methanol and ethylene glycol poisoning. Acta Med Scand. 1982;212:17-20. CrossrefMedlineGoogle Scholar1. BROWNTRUMBULLKLEIN-SCHWARTZWALKER CDWJ. Ethylene glycol poisoning. Ann Emerg Med. 1983;12:501-6. CrossrefMedlineGoogle Scholar2. JACOBSENOVREBOOSTBORGSEJERSTED DSJO. Glycolate causes the acidosis in ethylene glycol poisoning and is effectively removed by hemodialysis. Acta Med Scand. 1984;216:409-16. CrossrefMedlineGoogle Scholar3. GABOWCLAYSULLIVANLEPOFF PKJR. Organic acids in ethylene glycol intoxication. Ann Intern Med. 1986;105:16-20. LinkGoogle Scholar4. GABOWKAEHNYFENNESSEYGOODMANGROSSSCHRIER PWPSPR. Diagnostic importance of an increased serum anion gap. N Engl J Med. 1980;303:854-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMethanol and Ethylene Glycol IntoxicationEthanol, Methanol, and Ethylene GlycolColorimetric and Gas Chromatographic Procedures for Glycolic Acid in Serum: The Major Toxic Metabolite of Ethylene GlycolEthylene Glycol IntoxicationEthylene Glycol Poisoning: Experiences from an Epidemic in Sweden 1 November 1986Volume 105, Issue 5Page: 799-800KeywordsAcidosisAcidsBicarbonatesEthyleneIntoxicationLactates Issue Published: 1 November 1986 PDF DownloadLoading ...