tbuckley/cabot-search huggingface dataset:
Demand Pacemaker for Refractory Paroxysmal Supraventricular Tachycardia
Authors: James G. Kitchen, Bruce N. Goldreyer
Journal: New England Journal of Medicine (1972)

PAROXYSMAL supraventricular tachycardia may resist conventional drug therapy and seriously incapacitate the patient. Electrophysiologic studies may help to define refractory cases in which alternative nonpharmacologic measures may be of value. In the patient described below, competitive ventricular pacing was used to terminate episodes of refractory supraventricular tachycardia not associated with the pre-excitation syndrome. The mechanism ol action was demonstrated to be retrograde depolarization of the atrioventricular nodal tissues responsible for maintenance of the tachycardia.Case ReportA 28-year-old woman was admitted to the Hospital of the University of Pennsylvania in 1964 because of recurrent episodes of rapid heart action associated . . .
Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain
Authors: Netanel A. Horowitz, Elizabeth A. Blevins, Whitney M. Miller, Ashley R. Perry, Kathryn E. Talmage, Eric S. Mullins, Matthew J. Flick, Karla C. S. Queiroz, Kun Shi, C. Arnold Spek, Edward M. Conway, Brett P. Monia, Hartmut Weiler, Jay L. Degen, Joseph S. Palumbo
Journal: Blood (2011)
Therapy and survival after recurrence of Ewing’s tumors: the Rizzoli experience in 195 patients treated with adjuvant and neoadjuvant chemotherapy from 1979 to 1997
Authors: G. Bacci, S. Ferrari, A. Longhi, D. Donati, M. De Paolis, C. Forni, M. Versari, E. Setola, A. Briccoli, E. Barbieri
Journal: Annals of Oncology (2003)
TV: Killing for profit: where is the outrage?
Authors: J. Foulds
Journal: BMJ (1999)

Tobacco Wars , BBC1, Tuesday at 10 20 pm, 20 July to 3 August

This series, presented by journalist Michael Buerk, claims to “go behind the battle lines in the tobacco war to reveal the secrets of a century of smoking.” The programme style is that of a historical documentary, chequered with interviews with “celebrity smokers” such as comedians Jo Brand and Dave Allen and star of the Eastenders soap June Brown (Dot Cotton), and the personal experiences of Michael Buerk, including undergoing a bronchoscopy for the programme.



Alex Higgins: snookered by the tobacco industry

Credit: BBC



The first programme outlined the history of tobacco in Britain and the United States up to 1964. This included some revealing interviews with current and former senior employees of the tobacco industry. For example, Sir Duncan Oppenheim (former chairman of British American Tobacco) expressed his “great shock to find that tobacco caused lung cancer.” This was followed by an industry advertising executive informing viewers (with reference to the popularisation …
Pathogenesis of cerebral edema after treatment of diabetic ketoacidosis
Authors: Stephen M. Silver, Edward C. Clark, Barbara M. Schroeder, Richard H. Sterns
Journal: Kidney International (1997)

We studied the roles of acidosis, plasma osmolality, and organic osmolytes in the pathogenesis of cerebral edema in an animal model of diabetes mellitus. Normonatremic rats with streptozotocin-induced non-ketotic (NKD) and ketotic (DKA) diabetes were sacrificed before or after treatment with hypotonic saline and insulin. Brains were analyzed for water, electrolyte, and organic osmolyte content. Brain water decreased by 2% in untreated DKA and NKD despite a 12% increase in plasma osmolality due to hyperglycemia. After treatment of both NKD and DKA, brain water increased equivalently by 8%. The cerebral edema that occurred after treatment was associated with decreased brain sodium content and no change in total major brain organic osmolytes in both NKD and DKA. However, brain content of the individual osmolytes glutamine and taurine increased after treatment of DKA. In a separate study, brain water and solute content of rats with DKA were compared after treatment with either hypotonic or isotonic fluid. Animals treated with isotonic fluid had significantly less cerebral edema and higher brain sodium content than those treated with hypotonic fluid. In our studies, brain swelling after treatment of DKA and NKD was primarily due to a rapid reduction of plasma glucose and osmolality, and was not caused by sodium movement into the brain. Acidosis did not appear to play a major role in the pathogenesis of cerebral edema after treatment of DKA.
Mediterranean diets reduced cardiovascular events more than a low-fat diet in high-risk persons
Authors: Paul Glasziou
Journal: Annals of Internal Medicine (2013)

ACP Journal Club18 June 2013Mediterranean diets reduced cardiovascular events more than a low-fat diet in high-risk personsPaul Glasziou, RACGP, PhDPaul Glasziou, RACGP, PhDBond University, Gold Coast, Queensland, Australia (P.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-12-201306180-02003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationEstruch R, Ros E, Salas-Salvado J, et al; PREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368:1279-90. https://pubmed.ncbi.nlm.nih.gov/23432189Clinical Impact RatingsGIM/FP/GP: Cardiology: References1 de Lorgeril M, Renaud S, Mamelle N, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 1994;343:1454-9. [PMID: 7911176] Google Scholar2 Nordmann AJ, Suter-Zimmermann K, Bucher HC, et al. Meta-analysis comparing Mediterranean to low-fat diets for modification of cardiovascular risk factors. Am J Med. 2011;124:841-51.e2. [PMID: 21854893] Google Scholar3 Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012;308:1024-33. [PMID: 22968891] Google Scholar4 Predimed Study Group. PREDIMED. www.predimed.org (accessed 13 Apr 2013). Google Scholar Author, Article, and Disclosure InformationAuthors: Paul Glasziou, RACGP, PhDAffiliations: Bond University, Gold Coast, Queensland, Australia (P.G.)This article was published at Annals.org on 4 June 2013. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 June 2013Volume 158, Issue 12Page: JC3KeywordsCardiovascular disease riskCoronary heart diseaseDietMedical risk factorsMortalityMyocardial infarctionOilsSafetyType 2 diabetes ePublished: 18 June 2013 Issue Published: 18 June 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Diabetic Kidney Disease in Pima Indians
Authors: Robert G Nelson, William C Knowler, David J Pettitt, Mohammed F Saad, Peter H Bennett
Journal: Diabetes Care (1993)

OBJECTIVE— To describe the natural history of kidney disease in Pima Indians with NIDDM. RESEARCH DESIGN AND METHODS— Review of previous studies describing diabetic kidney disease in this Native-American population and in other populations. RESULTS— NIDDM is the leading cause of renal failure in Pima Indians, among whom the incidence of ESRD is 23 times that of the general U.S. population. The high incidence of NIDDM and its early onset in the Pima undoubtedly contribute to this difference. The incidence of overt nephropathy and ESRD, as a function of diabetes duration, is at least as high in Pima Indians with NIDDM as that reported in other populations with IDDM. Furthermore, nearly all of the excess mortality associated with NIDDM is found in individuals with overt nephropathy. Mild elevations of UAE, which may be present even shortly after the onset of diabetes, predict the development of overt nephropathy in diabetic Pimas. Additional predictors include high blood pressure, level of glycemia, duration of diabetes, family history of diabetic nephropathy, and type of diabetes treatment. CONCLUSIONS— Diabetic kidney disease is a major cause of morbidity and mortality in Pima Indians. The natural history of diabetic kidney disease in this population is similar, in many ways, to the natural history described in individuals with IDDM.
Health in a Rural Hippie Commune
Authors: Darwin L. Palmer
Journal: JAMA (1970)

All cooperating members of a small hippie commune in rural New Mexico were examined carefully for evidence of past or present illness. Current illness was infrequently documented although most had complaints of recent diarrhea, pharyngitis, cough, or gonorrhea, or the finding of an elevated serum glutamic oxaloacetic transaminase level, or abnormal results of an infectious mononucleosis spot test (Monospot). Medical attention was either accepted passively or not at all. No illnesses posing hazards to neighboring communities were apparent and the incidence of "hard" drug use was low. The observations may be relevant to other groups of young people living in such communes, the numbers of which are now large and probably increasing.
Factors related to periodontal regeneration
Authors: JACK G. CATON, GARY GREENSTEIN
Journal: Periodontology 2000 (1993)

The purpose of this chapter is to set the stage for the more detailed information to follow in the succeeding sections of this work. The reader will be familiarized with the terms and definitions commonly used in periodontal wound healing and the methods used to evaluate the results of periodontal therapy. A discussion of the effects of conventional periodontal therapy will then be followed by a review of biological factors that must be considered if periodontal therapy is to result in regeneration.
Isolation and characterization of hepatic Golgi lipoproteins from hypercholesterolemic rats.
Authors: L L Swift, N R Manowitz, G D Dunn, V S LeQuire
Journal: Journal of Clinical Investigation (1980)

The feeding of cholesterol-rich diets alters the serum lipoproteins of a number of mammalian species. These lipoproteins are characterized by the presence of several classes of particles enriched in cholesteryl esters and apolipoprotein E (apo E). It was the aim of this study to determine whether one or more of these particles arises by de novo hepatic synthesis by characterizing nascent lipoproteins isolated from the hepatic Golgi apparatus of hypercholesterolemic rats. Characterization of these lipoproteins afforded the opportunity to assess morphologic, biochemical, and biophysical properties of newly synthesized lipoproteins before enzymatic alterations and apoprotein transfer known to occur after secretion into the plasma compartment. Golgi very low density lipoproteins (VLDL, d < 1.006 g/ml) from hypercholesterolemic rats contained nearly four times the total cholesterol mass found in control Golgi VLDL. They exhibited electrophoretic mobility intermediate between beta and pre-beta and were devoid of apo C. A second population of hepatic Golgi lipoproteins was isolated from hypercholesterolemic rats at 1.006--1.040 g/ml d. These low density lipoproteins were smaller than VLDL, displayed beta electrophoretic mobility, were enriched in cholesteryl esters, and contained apo E as well as apo B. The fatty acid composition of the core lipids of the nascent lipoproteins was found to reflect that of dietary triglyceride. The liver of the hypercholesterolemic rat thus plays an active role in dietary-induced hypercholesterolemia by synthesizing a modified VLDL and a low density lipoprotein resembling serum low density lipoprotein.
Diesel Exhaust Particles Induce Cysteine Oxidation and S-Glutathionylation in House Dust Mite Induced Murine Asthma
Authors: G.B. Lee, E.B. Brandt, A.M. Gibson, T.D. Le Cras, L.S. Brown, A.M. Fitzpatrick, G.K. Khurana Hershey
Journal: Journal of Allergy and Clinical Immunology (2012)
Government and Medical Education
Authors: Scott A. Levin
Journal: Annals of Internal Medicine (2000)

Letters7 November 2000Government and Medical EducationScott A. Levin, MDScott A. Levin, MDLoyola Stritch School of Medicine; Maywood, IL 60153 (Levin)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-9-200011070-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Kefalides did a nice job summarizing some of the issues surrounding the role of government in medical education (1).However, I was dismayed to read a section quoting Wanda Wallis from the Medical Board of California. She states that she was unable to document the compliance of Loyola Stritch School of Medicine with the family medicine clerkship requirement. I am happy to report that our family medicine clerkship, required at the school, has been the highest-rated clerkship since 1995. Family medicine is the second most frequently chosen specialty of our graduates (internal medicine is first), and ...Reference1. Kefalides PT. The invisible hand of the government in medical education. Ann Intern Med. 2000;132:686. LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Scott A. Levin, MDAffiliations: Loyola Stritch School of Medicine; Maywood, IL 60153 (Levin) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Invisible Hand of the Government in Medical Education Paul T. Kefalides Metrics 7 November 2000Volume 133, Issue 9Page: 750KeywordsGraduate medical educationMedical educationResidency ePublished: 7 November 2000 Issue Published: 7 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Alfa-interferon in the treatment of essential thrombocythemia: clinical results and evaluation of its biological effects on the hematopoietic neoplastic clone
Authors: S Sacchi, L Gugliotta, F Papineschi, AM Liberati, S Rupoli, C Delfini, M Ruggeri, L Cavanna, A Bucalossi, E Benedetti, C Ferrandina, G Vinci, M Morselli, G Torelli
Journal: Leukemia (1998)
Non-steroidal anti-inflammatory drug-induced jejunal and colonic diaphragm disease.
Authors: F Halter, T H Huber, C H Ruchti
Journal: Gut (1993)

Non-steroidal anti-inflammatory drug- induced jejunal and colonic diaphragm disease EDITOR, -Fellows and his colleagues (Gut 1992; 33: 1424-6) claim that 'most previously reported cases have shown ileal disease and no case to date has shown involvement of the colon.'We would like to draw your attention to the fact that we published a case of diaphragm disease of the colon in the April issue of Gastroenterology in 1991' several months before the case report of Fellows et al was published in Gut.We were more cautious in asking for priority and we stated 'that to our knowledge such a case had not been observed before.'The caution was indeed justified as we then saw several additional cases in a short time.We submitted this extended case report for publication to a well honoured British journal and we were informed that our cases did not contribute to the better understanding of this established condition.Moreover, Dr H Spiro, the editor of Clinical Gastroenterology, where the paper was subsequently accepted for pub- lication,2 was kind enough to draw our atten- tion to an earlier publication of two such cases in the Lancet, in 1989.Additionally we found a recent report in endoscopic studies.4We thus agree with a Lancet editorial in 1989 that colonic damage by non-steroidal anti- inflammatory drugs is probably very common.5It is of interest that all the seven cases we have seen up to now were treated with diclofenac, applied in slow release form, and it is possible that we have seen a whole series of such cases in less than two years as this drug is manufactured in Switzerland and is the most common non- steroidal anti-inflammatory drug in use in our country.It is nevertheless appreciated
Vulnerable Elders
Authors: Carmel Bitondo Dyer, Sabrina Pickens, Jason Burnett
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Length of Medical Education-Reply
Authors: William F. Hejna
Journal: JAMA (1976)

Dr Hamilton makes  reasonable point that modern teaching techniques and formats have introduced some efficiencies in learning and some elimination of duplication. Many medical school curricula (including ours) have adopted an organ system approach and find it highly satisfactory. It does not, however, make the new knowledge... easier to learn faster.  Several statements made by Dr Hamilton are refutable and do not warrant discussion. Examples include  following: Unfortunately,  basic science is taught by PhDs who usually cannot integrate their disciplines into organ systems; most medical school deans and faculty are unable to change their traditional ways; and  far as postgraduate training goes, much of it is wasted.  The suggestion that a five-year health professions course be available is also not unreasonable. We simply must then recognize what skills and limitations such individuals have and certify their functions appropriately. Nurse clinicians undoubtedly approach this from
Prevention of Yellow Fever.
Authors: W. H. Doughty
Journal: JAMA (1894)

Augusta, Ga., Feb. 16, 1894. Dr. J. McFadden Gaston, Atlanta,Ga.: <h3>Dear Doctor:</h3> —I have just read your "Open Letter upon the Prevention of Yellow Fever by Inoculation" in the January number of the<i>Southern Medical Record</i>, reprinted from theJournal of the American Medical Association, of January6. If by this writing I can "hold up Moses' hand" I shall feel repaid, however unnecessary that aid may appear to one, who, in the strength of his resources, proclaims his ability and purpose to present "before the medical profession at an early day, facts in his possession confirmatory of<i>all</i>that has been alleged in favor of the results of inoculation against yellow fever, as practiced by Domingos Friere in Brazil." The subject is one of overwhelming importance as well as public interest. That your presentation of the data at hand will be acceptable, I need not assure you; the profession
Abnormally Increased Uptake on Bone Scintigraphy in the Long Bone Proximal to a Tourniquet
Authors: Myung-Hee Sohn, Seok Tae Lim, Young Jin Jeong, Dong Wook Kim, Hwan-Jeong Jeong, Chang-Yeol Yim
Journal: Clinical Nuclear Medicine (2010)

Tc-99m methylene diphosphonate bone scintigraphy was performed to evaluate for metastases in a 55-year-old man with advanced gastric cancer. Diffuse increased tracer uptake was noted in the right radius proximal to a tourniquet application for intravenous radiotracer injection. A plain radiograph showed no abnormality. On the follow-up bone scintigraphy performed 2 days later, no abnormal uptake was detected in the right radius. The first increased tracer uptake was suggested to be an injection artifact which appeared in the long bone proximal to the tourniquet application, and should be differentiated from true bone lesions.
US Democrats work to reconcile two health reform bills
Authors: J. H. Tanne
Journal: BMJ (2010)

US Democrats face several obstacles as they work to merge the two different health reform bills passed by the House of Representatives in November and by the Senate on Christmas Eve.

The first obstacle is holding together their 60-40 majority in the Senate over the Republicans, who want to defeat the health reform bills. The Democrats must hold on to their 60 votes (by 58 Democrats and two independents who vote with them), or the Republicans can defeat the merged health reform bill by filibuster—talking the bill to death. The Democrats have a wider safety margin in the House.

The usual way to reconcile two different bills is by a joint House-Senate conference committee. However, because Republicans uniformly oppose the health reform bills, that approach would give them …
Major histocompatibility complex class II expression deficiency caused by a RFXANK founder mutation: a survey of 35 patients
Authors: Monia Ouederni, Quentin B. Vincent, Pierre Frange, Fabien Touzot, Sami Scerra, Mohamed Bejaoui, Aziz Bousfiha, Yves Levy, Barbara Lisowska-Grospierre, Danielle Canioni, Julie Bruneau, Marianne Debré, Stéphane Blanche, Laurent Abel, Jean-Laurent Casanova, Alain Fischer, Capucine Picard
Journal: Blood (2011)
Acyclovir Suppression of Frequently Recurring Genital Herpes
Authors: Stephen E. Straus
Journal: JAMA (1988)

Forty-seven patients with frequently recurring genital herpes participated in one or more of five sequential trials of oral suppressive therapy with 200 mg of acyclovir three times daily from four to 12 months' duration. The prolonged use of acyclovir was extremely well tolerated, and treatment efficacy was sustained through successive studies. Recurrences in eight patients with repeated treatment "failures" were more effectively suppressed with higher doses of acyclovir. All patients experienced recurrent infections after the treatments were completed; however, the mean time to recurrence following each treatment period became progressively longer, and resumption of suppressive therapy was no longer warranted for ten patients. These data indicate the efficacy and safety of chronic suppressive therapy with acyclovir and the value of interrupting prolonged treatment to assess its further need.