Aluminum and Osteomalacia After Parathyroidectomy
Authors: H.A. ELLIS
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 April 1982Aluminum and Osteomalacia After ParathyroidectomyH.A. ELLIS, M.D., PH.D.H.A. ELLIS, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-4-533_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I was most interested to read the paper by Dr. Felsenfeld and colleagues (1) describing osteomalacia in dialysis patients after parathyroidectomy, and wish to suggest that the osteomalacia could have been aluminum-induced.The characteristic clinical picture of fracturing dialysis osteodystrophy results from a special form of osteomalacia that fails to respond to treatment with the newer vitamin D metabolites such as 1-alpha-hydroxyvitamin D3. Histologic examination shows reduced mineralised bone and excess surface lamellar osteoid comprising abnormally thick seams with an absent or reduced mineralisation front and inconspicuous overlying osteoblasts (2). The unusual histologic feature is the presence...References1. FELSENFELD A, HARRELSON J, GUTMAN R, WELLS S, and DREZNER M. Osteomalacia after parathyroidectomy in patients with uremia. Ann Intern Med. 1982;96:34-9. LinkGoogle Scholar2. ELLIS H, PIERIDES A, FEEST T, WARD M, and KERR D. Histopathology of renal osteodystrophy with particular reference to the effects of 1 alpha-hydroxyvitamin D3 in patients treated by long-term haemodialysis. Clin Endocrinol. 1977; 7 (Suppl): 31-8. CrossrefMedlineGoogle Scholar3. ELLIS H, MCCARTHY J, and HERRINGTON J. Bone aluminum in haemodialysed patients and in rats injected with aluminium chloride: relationship to impaired bone mineralisation. J Clin Pathol. 1979;32:832-44. CrossrefMedlineGoogle Scholar4. BOYCE B, ELDER H, and FELL G. Quantitation and localisation of aluminium in human cancellous bone in renal osteodystrophy. Scan Electron Microsc. 1981;3:329-37. Google Scholar5. PEARSE A. Histochemistry Theorectical and Applied. 3rd ed. Vol. 2. Edinburgh and London; Churchill Livingstone; 1972: 1406-9. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H.A. ELLIS, M.D., PH.D.Affiliations: Royal Victoria Infirmary Newcastle upon Tyne, NE1 4LP England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTotal parathyroidectomy without autotransplantation after renal transplantation for tertiary hyperparathyroidism: long-term follow-upMineral and bone disorder after renal transplantation: a reviewMetabolic Bone Disease of Total Parenteral NutritionRenal osteodystrophyBone and Mineral Metabolism in Childhood End-Stage Renal DiseaseTotal Parenteral Nutrition and Its Effects on Bone MetabolismRenal bone disease 1990: An unmet challenge for the nephrologistSerum bone Gla protein as an indicator of parathyroidectomy in patients with secondary hyperparathyroidismRisk factors for aluminum toxicity and its preventionThe influence of early parathyroidectomy on aluminum-induced rickets in growing uremic ratsRenal Osteodystrophy and Maintenance DialysisAluminium Toxicity in Renal FailureToxic Effects of Aluminum in End-Stage Renal Disease: Discussion of a CaseRecent advances and controversies in childhood renal osteodystrophyCase report: High bone turnover associated with an aluminum-induced impairment of bone mineralizationClinical and Laboratory Features of Aluminum-Related Bone Disease: Differences Between Sporadic and “Epidemic” Forms of the SyndromeEffects of parathyroidectomy on bone formation and mineralization in hemodialyzed patientsRole of Aluminum Accumulation in Renal OsteodystrophyChanges Following Parathyroidectomy in Hemodialyzed PatientsRenal Osteodystrophy 1 April 1982Volume 96, Issue 4Page: 533-534KeywordsBoneMedical dialysisMetabolitesParathyroidectomyVitamin D ePublished: 1 December 2008 Issue Published: 1 April 1982 PDF downloadLoading ...