tbuckley/cabot-search huggingface dataset:
Hematopoiesis and Cerebellar Hemangioblastoma-Reply
Authors: George J. Race
Journal: JAMA (1964)

The comments of Dr. Mortimer Lorber are well taken. I agree with most of them. The purpose of this short report was to stimulate interest of pathologists and surgeons in obtaining this type of material. I am sure Dr. Lorber and others would be interested in the assay of tumor fluid from similar cases. It is unfortunate that most cases of this type have not been extensively studied hematologically prior to the operative procedure. The work of Starr et al<sup>1</sup>should have been cited as reference No. 9 instead of that of Donati et al. Other communications on this subject have been published by Cramer and Kimsey<sup>2</sup>and by Josephs et al.<sup>3</sup>On page 151, "/cu mm" with reference to reticulocyte count should be deleted. The magnifications for the two figures should have appeared as follows: Fig 1, "X 600"; Fig 2, "X 300."
Geriatric Doses-Reply
Authors: Raymond Vickers
Journal: JAMA (1975)

<h3>In Reply.—</h3> It is true that extra care should be exercised when prescribing medication for elderly patients because of the prevalence of side effects and complications. We do not agree, however, with the broad generalization that doses of psychoactive medications are lower than doses for younger people; each case must be treated individually to achieve a satisfactory serum level. We find that the use of capsules produces a more predictable serum level. Studies we performed four years ago showed that some tablets remained intact and were excreted in the stools. The purpose of our article was to point out that dysphasia may occur as an isolated effect of lithium administration in the absence of true toxicity. The patient is almost unaware of the symptom and suffers no real inconvenience from it. We think that it is better not to give a medication at all if the dosage level is too
Two preproendothelin 1 mRNAs transcribed by alternative promoters.
Authors: L Benatti, L Bonecchi, L Cozzi, P Sarmientos
Journal: Journal of Clinical Investigation (1993)

Endothelin-1, initially identified as potent vasoconstrictor secreted by vascular endothelial cells, was subsequently found to have many effects on both vascular and nonvascular tissues. We have identified from a human placenta cDNA library a clone (cDNA-2) which corresponds to a novel 5'-extended preproendothelin 1 (preproET-1) mRNA. Comparison with the known preproET-1 mRNA (cDNA-1), showed that the two molecules share the same coding sequence but differ in the 5'-untranslated region. Interestingly, cDNA-2 extends upstream of promoter regions previously shown to be essential for full preproET-1 expression. Primer extension and PCR analysis of human placenta RNA demonstrated the presence of additional transcription initiation sites located upstream of the previously identified preproET-1 CAP site. Moreover, the two mRNAs show different pattern of expression. To elucidate the mechanisms controlling the production of alternative transcripts we transfected COS-1 cells with a series of preproET-1 promoter deletion mutants. This analysis revealed that the human preproET-1 gene can be transcribed from a proximal and a distal promoter element which has hitherto been undetected. In addition, we demonstrate the presence of a region in the down-epithelial specific expression.
The Monkey-Puzzle Tree
Authors: S. Spence
Journal: BMJ (1995)

Elizabeth Nickson Bloomsbury, pounds sterling5.99, pp 277 ISBN 0 7475 2038 0

The Monkey-Puzzle Tree is ill served both by its melodramatic cover and by the publishers' blurb. In fact it is far more compelling than is implied, and for other reasons.

Elizabeth Nickson has written a novel purporting to outline the events surrounding her mother's mistreatment at the hands of psychiatrists in Canada in the era of the Cold War. The time is relevant, for the mode of “therapy” dispensed was part of a wider …
Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance
Authors: Daniel Kreisel, Seiichiro Sugimoto, Jihong Zhu, Ruben Nava, Wenjun Li, Mikio Okazaki, Sumiharu Yamamoto, Mohsen Ibrahim, Howard J. Huang, Kelsey A. Toth, Jon H. Ritter, Alexander S. Krupnick, Mark J. Miller, Andrew E. Gelman
Journal: Blood (2011)
Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo
Authors: Yunzhou Dong, Miao Zhang, Bin Liang, Zhonglin Xie, Zhengxing Zhao, Sima Asfa, Hyoung Chul Choi, Ming-Hui Zou
Journal: Circulation (2010)

Background— Aberrant endoplasmic reticulum (ER) stress is associated with several cardiovascular diseases, including atherosclerosis. The mechanism by which aberrant ER stress develops is poorly understood. This study investigated whether dysfunction of AMP-activated protein kinase (AMPK) causes aberrant ER stress and atherosclerosis in vivo. Methods and Results— Human umbilical vein endothelial cells and mouse aortic endothelial cells from AMPK-deficient mice were used to assess the level of ER stress with Western blotting. Reduction of AMPKα2 expression significantly increased the level of ER stress in human umbilical vein endothelial cells. In addition, mouse aortic endothelial cells from AMPKα2 knockout (AMPKα2 −/− ) mice had higher expression of markers of ER stress and increased levels of intracellular Ca 2+ . These phenotypes were abolished by adenovirally overexpressing constitutively active AMPK mutants (Ad-AMPK-CA) or by transfecting sarcoendoplasmic reticulum calcium ATPase (SERCA). Inhibition of SERCA induced ER stress in endothelial cells. Furthermore, reduction of AMPKα expression suppressed SERCA activity. In addition, SERCA activity was significantly reduced concomitantly with increased oxidation of SERCA in mouse aortic endothelial cells from AMPKα2 −/− mice. Both of these phenotypes were abolished by adenovirally overexpressing Ad-AMPK-CA. Furthermore, Tempol, which restored SERCA activity and decreased oxidized SERCA levels, markedly reduced the level of ER stress in mouse aortic endothelial cells from AMPKα2 −/− mice. Finally, oral administration of tauroursodeoxycholic acid, a chemical chaperone that inhibits ER stress, significantly reduced both ER stress and aortic lesion development in low-density lipoprotein receptor– and AMPKα2-deficient mice. Conclusion— These results suggest that AMPK functions as a physiological suppressor of ER stress by maintaining SERCA activity and intracellular Ca 2+ homeostasis.
Effects of Felted Foam on Plantar Pressures in the Treatment of Neuropathic Diabetic Foot Ulcers
Authors: Stefan Zimny, Bernadette Reinsch, Helmut Schatz, Martin Pfohl
Journal: Diabetes Care (2001)

It is generally accepted that (besides infection control and revascularization, when necessary) pressure relief is the most important measure in the treatment of diabetic foot ulcers. The use of felted foam dressings is a promising but not yet well-standardized technique for the treatment of neuropathic diabetic foot ulcers and may have some advantage over total contact casting (1,2,3,4). We aimed to assess the effects of felted foam on plantar pressure reduction during the therapy of neuropathic foot ulcers and to define the optimal time course for renewal of the felted foam according to the plantar pressure. Using felted foam dressings, plantar pressure reduction and wound healing was determined in 9 type 1 and 19 type 2 diabetic patients (15 men and 13 women, aged 61.0 ± 13.6 years) with neuropathic foot ulcers up to a Wagner grade 2. Physical examination included the inspection of the foot and the palpation of the peripheral pulses. Peripheral diabetic neuropathy was evaluated by measuring the vibration …
Screening for HTLV-III Antibodies: The Relation Between Prevalence and Positive Predictive Value and Its Social Consequences-Reply
Authors: Stanley H. Weiss
Journal: JAMA (1985)

In Reply.—  The predictive value of a test, such as the HTLV-III antibody enzyme-linked immunosorbent assay, will vary significantly according to the characteristics of the population being tested (such as AIDS risk factors, geographic region and time period, and perhaps specific medical conditions). Barry et al, Miller, and Kleinman all focus on this important issue with regard to the blood bank setting, which requires estimation of the true-positive rate (prevalence) within the test group. We lacked sufficient data and external criteria by which to assess accurately current HTLV-III seroprevalence among various blood donor groups to perform this calculation. We agree with Barry et al that optimal test operating characteristics may vary with the proposed application, and, as pointed out by Dr Miller, we carefully outlined the implications of such varying approaches. We emphatically agree that HTLV-III testing must not be performed casually for a multitude of research and social reasons.
Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML
Authors: Anupriya Agarwal, Angela G. Fleischman, Curtis L. Petersen, Ryan MacKenzie, Samuel Luty, Marc Loriaux, Brian J. Druker, Randall L. Woltjer, Michael W. Deininger
Journal: Blood (2012)
Evaluating the Use of ABBA–BABA Statistics to Locate Introgressed Loci
Authors: Simon H. Martin, John W. Davey, Chris D. Jiggins
Journal: Molecular Biology and Evolution (2014)

Several methods have been proposed to test for introgression across genomes. One method tests for a genome-wide excess of shared derived alleles between taxa using Patterson's D statistic, but does not establish which loci show such an excess or whether the excess is due to introgression or ancestral population structure. Several recent studies have extended the use of D by applying the statistic to small genomic regions, rather than genome-wide. Here, we use simulations and whole-genome data from Heliconius butterflies to investigate the behavior of D in small genomic regions. We find that D is unreliable in this situation as it gives inflated values when effective population size is low, causing D outliers to cluster in genomic regions of reduced diversity. As an alternative, we propose a related statistic ƒ(d), a modified version of a statistic originally developed to estimate the genome-wide fraction of admixture. ƒ(d) is not subject to the same biases as D, and is better at identifying introgressed loci. Finally, we show that both D and ƒ(d) outliers tend to cluster in regions of low absolute divergence (d(XY)), which can confound a recently proposed test for differentiating introgression from shared ancestral variation at individual loci.
Corrected data and analysis of hemodynamic variables influencing plasma endothelin.
Authors: R J Cody
Journal: Circulation (1993)

TABLE 1. Mean Values of Lp(a), Cholesterol, Triglycerides, and C Reactive Protein in 30 Patients Treated With Heparin (10,000 IU) During PTCA Before PTCA End of PTCA 4 Hours after PTCA Lp(a) (mg/dl) 58.57+41.5516.92±10.72*21.15±11.72*Cholesterol (mg/dl) 176.83±41.66168.13±24.42175.61±29.43Triglycerides (mg/dl) 145.80±102.3988.10±64.34
GENOTYPE-DEPENDENT IMPAIRMENT OF HEMOGLOBIN CLEARANCE INCREASES OXIDATIVE STRESS AND INFLAMMATION LEADING TO ACCELERATED NEOVASCULARIZATION IN HUMAN DIABETIC ATHEROSCLEROSIS
Authors: Meerarani Purushothaman, Purushothaman K-Raman, Prakash Krishnan, Andrew P. Levy, Patrick A. Lento, Roxana Mehran, Annapoorna Kini, Samin K. Sharma, Valentin Fuster, Pedro R. Moreno
Journal: Journal of the American College of Cardiology (2011)
Changing Patterns in the Practice of Carotid Endarterectomy in a Large Metropolitan Area
Authors: Thomas G. Brott, Robert J. Labutta, Richard F. Kempczinski
Journal: JAMA (1986)

Changes in the practice of carotid endarterectomy were studied by review of all endarterectomies performed in the greater Cincinnati area during 1980 and from July 1983 through June 1984. The number of operations rose from 431 to 750 (74% increase). The perioperative stroke rate fell from 8.6% in 1980 to 5.1% in 1983-1984; operative mortality declined from 2.8% to 2.3%; and the combined stroke or death rate declined from 9.5% to 6.5%. Asymptomatic carotid artery disease was the indication for 50% of the endarterectomies during both time periods. The combined stroke or death rate for asymptomatic patients declined from 6.9% to 5.3%, but both rates were higher than the 3% suggested as acceptable for prophylactic carotid endarterectomy. We conclude that carotid endarterectomy is becoming an increasingly common procedure, that morbidity continues to decline, and that mortality continues to be significant. Citywide surgical morbidity and mortality remain excessive for patients with asymptomatic carotid disease.
Renal Glycosuria With a False-Positive Glucose Tolerance Test
Authors: Lewis H. Seager
Journal: JAMA (1965)

RENAL GLYCOSURIA is usually differentiated from diabetes mellitus by the presence of an abnormal glucose tolerance test in the latter condition. For many years it has been standard procedure that a patient should receive a diet containing at least 200 to 250 gm of carbohydrates daily for three days prior to a glucose tolerance test since carbohydrate restriction in itself has been shown to impair the use of glucose.<sup>1</sup>It would seem reasonable that some persons with renal glycosuria, who had considerable glucose loss in their urine, might have insufficient amounts of carbohydrates available for use despite a normal carbohydrate intake. The lack of sufficient usable carbohydrate, prior to the test, might lead to a false-positive glucose tolerance test in a person with renal glycosuria. The following case report seems to be an example of this phenomenon. <h3>Report of a Case</h3> The patient, a 19-year-old man, was admitted to
EPIDEMIOLOGY OF P WAVE INDICES IN HEALTHY POST-MENOPAUSAL WOMEN: THE WOMEN’S HEALTH INITIATIVE
Authors: Eiran Z. Gorodeski, Jared W. Magnani, Ronald J. Prineas, Mara Z. Vitolins, Mary J. O’Sullivan, Elsayed Z. Soliman, Lisa W. Martin, Marian C. Limacher, J. David Curb, Barbara B. Cochrane, Eugene H. Blackstone, Michael S. Lauer
Journal: Journal of the American College of Cardiology (2010)
THE THYROID AND MANGANESE TREATMENT: A SUGGESTION WITH REGARD TO ITS POSSIBLE MODE OF ACTION
Authors: H. W. Nott
Journal: BMJ (1928)

She still complains of a feeling of breathlessness, but this was a feature of the " nervous breakdown " two years ago.Anaesthesia to pinprick is still present, but is patchy in distribubion.Epicritic sensibilitv appears to show definite improvement.The feet are bluislh in colour and the skin is dry and atrophic; numbness, tingling, and cold- ness of the feet are still complained of, though less so.Knee-jerks and ankle-jerks are present and equal; the plantar reflex is flexor.-No retinal haemorrhages can be found.She it now permitted to replace one portion of the li-ver with underdone steak or kidneys on three days a week, and, oddly enough, prefers to replace the cooked por'tion rather than the raw.The raw liver can also be conveniiently given in sandwiches or in a jelly, which can be flavoured to taste with bovril, lemon, etc.It is, of course, too early to make any cla m to permanent effect, but the rapidity of improvement appears to be remarkable in a patient of this age.My thanks are due to Dr. H. M. McCrea for his kindness
Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes
Authors: Stefano Ugel, Elisa Scarselli, Manuela Iezzi, Carmela Mennuni, Tania Pannellini, Francesco Calvaruso, Barbara Cipriani, Raffaele De Palma, Lucia Ricci-Vitiani, Elisa Peranzoni, Piero Musiani, Paola Zanovello, Vincenzo Bronte
Journal: Blood (2009)
The Gelatin Method of Preserving Specimens.
Authors: Henry Albert
Journal: JAMA (1906)

Iowa City,Iowa, July 28, 1906. <h3>To the Editor:</h3> —It appears that my article on the gelatin method of preserving specimens, which appeared inThe JournalA. M. A., June 30, 1906, has created considerable interest as manifested by the communications of Professor Watters (seeThe JournalA. M. A., July 14) and Dr. Hall (July 28). In justice to Professor Watters I would like to say that I do not think that he claims to be the originator of the gelatin method of preserving specimens, but that he simply claims priority in the Petri-dish-glycerin-jelly method of mounting objects. In justice to myself, permit me to say that I did not claim in the original article to be the originator of the glycerin-jelly method of mounting specimens nor the first to conceive the idea of the use of the Petri-dish for that purpose. The idea of inclosing stained microscopic sections
Cardioversion of Paroxysmal Arrhythmias
Authors: Robert E. Kleiger
Journal: JAMA (1970)

Dr. Michael Cebrik, Junior Assistant Resident in Medicine, Jewish Hospital of St. Louis and Assistant in Medicine, Washington University School of Medicine: The first patient is a 68-year-old white woman who was admitted to Jewish Hospital for the second time on Aug 31, 1969, with a chief complaint of palpitations and a rapid heart rate. In September 1968, the patient had been hospitalized for similar complaints, at which time she was found to have atrial flutter with a 2:1 atrioventricular block and a ventricular rate of 140 beats per minute. Right bundle branch block, which had been present prior to this admission, was noted. The patient was treated with digoxin and warfarin sodium, and quinidine sulfate was added later. The cardiac rhythm varied from atrial flutter to atrial fibrillation with a ventricular response greater than 100 beats per minute. The quinidine effected a conversion to normal sinus rhythm and the
Genetic Variation in Angiotensin-Converting Enzyme Does Not Prevent Development of Cardiac Hypertrophy or Upregulation of Angiotensin II in Response to Aortocaval Fistula
Authors: Gilbert J. Perry, Tatsuhiko Mori, Chih-Chang Wei, Xiao Yan Xu, Yiu-Fai Chen, Suzanne Oparil, Pamela Lucchesi, Louis J. Dell’Italia
Journal: Circulation (2001)

Background —Experimental and clinical evidence suggests that angiotensin II may be an important mediator of cardiac hypertrophy in response to hemodynamic stress. We investigated the effect of genetic variation in angiotensin-converting enzyme (ACE) on the development of cardiac hypertrophy and left ventricular (LV) dysfunction in response to volume overload. Methods and Results —Male heterozygous ACE knockout (1/0) and wild-type (1/1) mice were studied 4 weeks after the creation of an aortocaval fistula (ACF). The LV weight/body weight ratio increased 74% in ACF versus sham-operated control mice but did not differ between genotypes. Echocardiographic circumferential stress versus rate-corrected velocity of circumferential shortening curves demonstrated depressed LV function in ACF versus sham-operated mice but no difference between genotypes. LV ACE activity was higher in 1/1 versus 1/0 mice and in ACF versus sham-operated mice, and it increased significantly more in the 1/1 versus the 1/0 mice after ACF ( P &lt;0.001 for effect of genotype, ACF/sham operation, and interaction term). LV angiotensin II was higher in ACF versus sham-operated mice but did not differ between genotypes, despite 3-fold higher LV ACE activity in ACF 1/1 versus ACF 1/0 mice. Conclusions —ACE underexpression does not prevent cardiac hypertrophy or LV dysfunction in response to volume overload. LV angiotensin II is unaffected by ACE genotype, both at baseline and after volume overload, indicating that the heart can maintain angiotensin II levels across a broad range of genetic ACE variation under both physiological and pathophysiological conditions.
Remission of lymphoma after withdrawal of methotrexate in rheumatoid arthritis: Relationship with type of latent Epstein‐Barr virus infection
Authors: Takuya Miyazaki, Katsumichi Fujimaki, Yukari Shirasugi, Fumiaki Yoshiba, Manabu Ohsaka, Koji Miyazaki, Etsuko Yamazaki, Rika Sakai, Jun‐ichi Tamaru, Kenji Kishi, Heiwa Kanamori, Masaaki Higashihara, Tomomitsu Hotta, Yoshiaki Ishigatsubo
Journal: American Journal of Hematology (2007)

Abstract Rheumatoid arthritis (RA) is associated with an increased risk of developing lymphoma. Although the pathogenesis is still unclear, the increased risk appears to be related to the high inflammatory activity of RA, immunosuppressive agents, or Epstein‐Barr virus (EBV) infection. We investigated the relationship between EBV latent infection and methotrexate (MTX)‐associated lymphoma in RA patients. Nine patients were diagnosed with non‐Hodgkin's lymphoma (NHL) during MTX treatment for RA in a multicenter study. The pathologic findings were consistent with diffuse large B‐cell lymphoma in 8 patients and peripheralT‐cell lymphoma, unspecified in 1. EBV infection was detected in 3 patients by in situ hybridization. Among all 9 patients who were initially treated by MTX withdrawal alone, 2 obtained spontaneous complete response (CR), 1 had partial response, 2 had stable disease (SD), and 4 had progressive disease. Both patients who had a CR and 1 who had SD were positive for EBV. Further examination of the latent EBV infection patterns revealed that 2 patients who obtained a CR had latency Type III, and the other with SD had latency Type II. These results demonstrate that immunodeficiency caused by MTX treatment is associated with the development of EBV‐related NHL in RA patients. In patients who were treated by MTX for RA and developed NHL, remission can be observed following MTX withdrawal especially in NHL with latency Type III EBV infection. The analysis of EBV infection, including the latency types, is useful to decide the optimum therapeutic strategy. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
JOHN EVELYN'S ACCOUNT OE A CASE OF DERMATITIS FICTA.
Authors: H. G. ADAMSON
Journal: British Journal of Dermatology (1937)

Journal Article JOHN EVELYN'S ACCOUNT OE A CASE OF DERMATITIS FICTA. Get access H. G. ADAMSON H. G. ADAMSON Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 49, Issue 10, 1 October 1937, Pages 435–436, https://doi.org/10.1111/j.1365-2133.1937.tb10377.x Published: 01 October 1937
For Michael Halberstam
Authors: RICHARD M. RATZAN
Journal: Annals of Internal Medicine (1981)

Ad Libitum1 September 1981For Michael HalberstamRICHARD M. RATZANRICHARD M. RATZANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-3-386 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHeartwords, murmurs of meaningyou recovered intact—private sounds uttered in confidence to a doctorwho listened in awe, and then translated . . .into prose.Was it because . . .Was it because you entered, hearing,others' lives that you wrote?"I practice medicine full time and then write about it," you said.But were you able, ever, to convince your patient,reading your words as you listened to his,that you were listening, together, to the same sound,that writing is recruitment,the translation of one's audible beinginto another's,a message received,a message enriched,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: West Hartford, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1981Volume 95, Issue 3Page: 386-386KeywordsHearing ePublished: 1 December 2008 Issue Published: 1 September 1981 PDF downloadLoading ...