tbuckley/cabot-search huggingface dataset:
Ophthalmoplegia Resulting From Diphenylhydantoin and Primidone Intoxication
Authors: David N. Orth
Journal: JAMA (1967)

Nystagmus, anisocoria, and disturbances in accommodation have been recognized as features of intoxication from excessive doses of both diphenylhydantoin and primidone; diplopia and defective convergence have been observed after diphenylhydantoin alone. In four cases, partial or total external ophthalmoplegia resulted from excessive ingestion of these antiepileptic drugs. In three of the cases it is not possible to state which of the agents was primarily responsible for the ophthalmoplegia. In one (case 3), however, it appears that diphenylhydantoin alone was involved.
Effective Tumor Cell Death by σ-2 Receptor Ligand Siramesine Involves Lysosomal Leakage and Oxidative Stress
Authors: Marie Stampe Ostenfeld, Nicole Fehrenbacher, Maria Høyer-Hansen, Christian Thomsen, Thomas Farkas, Marja Jäättelä
Journal: Cancer Research (2005)

Abstract Acquired resistance to classic caspase-mediated apoptosis is a common problem for the treatment of human cancer. Here, we show that siramesine, a novel σ-2 receptor ligand, effectively induces caspase-independent programmed cell death in immortalized and transformed cells of various origins. Siramesine-treated tumor cells displayed increased levels of reactive oxygen species, lysosomal membrane permeabilization, chromatin condensation, and shrinkage and detachment of cells. Lipid antioxidants (α-tocopherol and γ-tocopherol), but not other tested antioxidants (butylated hydroxyanisol or N-acetyl cysteine), effectively inhibited siramesine-induced morphologic changes and cell death. Cathepsin B inhibitors (CA-074-Me and R-2525) conferred similar, but less pronounced protection, whereas ectopic expression of antiapoptotic protein Bcl-2, lack of wild-type p53 as well as pharmacologic inhibitors of caspases (zVAD-fmk, DEVD-CHO, and LEHD-CHO), calpains (PD150606), and serine proteases (N-tosyl-l-phenylalanine chloromethyl ketone and pefabloc) failed to protect cells against siramesine-induced death. Importantly, transformation of murine embryonic fibroblasts with activated c-src or v-Ha-ras oncogenes greatly sensitized them to siramesine-induced cytotoxicity. Furthermore, p.o. administration of well-tolerated doses of siramesine had a significant antitumorigenic effect in orthotopic breast cancer and s.c. fibrosarcoma models in mice. These results present siramesine as a promising new drug for the treatment of tumors resistant to traditional therapies.
The Last of the 9th
Authors: Mayer B. Davidson
Journal: Diabetes Care (2006)

The Last of the 9th T o continue with the same theme as last year's editorial, "7th Inning Stretch" (1), this is the last of the 9th for this editorial team.Although our term doesn't end officially until the end of 2006, beginning in July, the new team takes over on the new manuscripts and we simply finish up on the ones already under our jurisdiction.So, what is the current status of the journal and what happened during the past year that will impact the new team as well as our authors, reviewers, and readers?Diabetes Care continues its preeminence in the field of clinical diabetes.One measure of the effect of a journal is its impact factor, the frequency with which the "average" article in a journal has been cited in a particular year.It is calculated as the number of current citations of articles published in the journal during the previous 2 years divided by the number of articles published in the journal during that period.The impact factor for Diabetes Care was 5.0 in 2000, 5.5 in 2002, and 7.5 in 2003 and was maintained at 7.1 in 2004, the last year for which the impact factor could be calculated.This places us 6th among all of the journals in the category of Endocrinology and Metabolism.
Reconfiguration of surgical, emergency, and trauma services
Authors: David G Currie
Journal: BMJ (2004)

Editor—Black's editorial on the reconfiguration of surgical, emergency, and trauma services in the United Kingdom discusses what is proving to be a destructive tendency in Scottish medicine and, I suspect, in UK medicine.1

A depressing trend prevails in Scotland to see centralisation (sometimes euphemistically described as creating “managed clinical networks”) as a reasonable solution to all the ills that currently afflict us. These include the new deal, the consultants' contract, the general practitioners' contract, the European Working Time Directive—all man-made artefacts and all preoccupied with the welfare of doctors, not patients.

A view dominates that unless something can be done to the standard of the Mayo Clinic it should not be done at all. This endangers our small and not so small district hospitals and our specialist services in the regions of Scotland and ultimately leads to the absurd conclusion that we have only one or two hospitals.

We should instead be looking at how we can improve medical services where our people live. We have to do this to encourage the survival and the development of our regional and rural cultures. Fewer and bigger hospitals are certainly not the answer. Other European countries recognise that, and I expect that our electorate will as well. If they don't some of us will be sure to tell them.
Dysregulated CD4<sup>+</sup>T cells from SLE-susceptible mice are sufficient to accelerate atherosclerosis in LDLr<sup>−/−</sup>mice
Authors: Ashley J Wilhelm, Jillian P Rhoads, Nekeithia S Wade, Amy S Major
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Objective</h3> Accelerated atherosclerosis is a major source of morbidity in systemic lupus erythematosus (SLE). However, the cause of SLE-accelerated atherosclerosis remains unclear. <h3>Methods</h3> CD4<sup>+</sup> T cells from C57/Bl/6 (B6) or SLE-susceptible B6.Sle1.2.3 (B6.SLE) mice were transferred into LDLr<sup>−/−</sup>, Rag<sup>−/−</sup> mice. T cells were examined for cytokine production and expression of interleukin-10 receptor (IL-10R) and functional markers. T cells were isolated based on FoxP3<sup>GFP</sup> expression and transferred to LDLr<sup>−/−</sup>, Rag<sup>−/−</sup> mice to establish a role for B6.SLE effector T cells (T<sub>eff</sub>) in atherosclerosis. <h3>Results</h3> Mice receiving whole B6.SLE CD4<sup>+</sup> T cells displayed no other SLE phenotype; however, atherosclerosis was increased nearly 40%. We noted dysregulated IL-17 production and reduced frequency of IL-10R expression by B6.SLE regulatory T cells (T<sub>reg</sub>). Functional assays indicated resistance of B6.SLE T<sub>eff</sub> to suppression by both B6.SLE and B6 T<sub>reg</sub>. Transfer experiments with CD4<sup>+</sup>FoxP3<sup>−</sup> T<sub>eff</sub> and CD4<sup>+</sup>FoxP3<sup>+</sup> T<sub>reg</sub> from B6.SLE and B6 mice, respectively, resulted in increased atherosclerosis compared with B6 T<sub>eff</sub> and T<sub>reg</sub> recipients. T<sub>reg</sub> isolated from mice receiving B6.SLE T<sub>eff</sub> with B6 T<sub>reg</sub> had increased production of IL-17 and fewer expressed IL-10R compared with B6 T<sub>eff</sub> and T<sub>reg</sub> transfer. <h3>Conclusions</h3> Transfer of B6.SLE T<sub>eff</sub> to LDLr<sup>−/−</sup>, Rag<sup>−/−</sup> mice results in accelerated atherosclerosis independent of the source of T<sub>reg</sub>. In addition, the presence of B6.SLE T<sub>eff</sub> resulted in more IL-17-producing T<sub>reg</sub> and fewer expressing IL-10R, suggesting that B6.SLE T<sub>eff</sub> may mediate phenotypic changes in T<sub>reg</sub>. To our knowledge, this is the first study to provide direct evidence of the role of B6.SLE T<sub>eff</sub> in accelerating atherosclerosis through resistance to T<sub>reg</sub> suppression.
Come Blow Your Horn
Authors: Anderson W. Donan
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Almost all paramedical publications seem to have a preponderance of articles promoting the cause of specialized medicine and predicting the extinction of general practice. Year after year it's the same story. After awhile, if you continue to read these magazines, you could easily believe that what they say is true even though approximately one half of the physicians in the United States are general practitioners. Compare any specialty alone with the field of general practice and we are clearly not extinct. Are our busy general practitioners too busy to write or to teach in medical schools, too busy to be active in medical societies? Maybe the rugged individualist of the past is gone and the family doctor of today is interested only in making a living and being concerned about his own isolated thoughts. If this is so, then he is extinct. Certainly it w'll be up
LIPOIDS AS INHIBITORS OF ANAPHYLACTIC SHOCK
Authors: James W. Jobling, William Petersen
Journal: The Journal of Experimental Medicine (1914)

1. The antitryptic titer of the serum can be increased by subcutaneous injections of serum lipoids (antitrypsin) and of the lipoids from egg yolk. 2. Animals so injected show a relative immunity to acute anaphylactic shock (two minimum lethal doses). 3. Extraction of lipoids contained in antigens increases the toxicity of the antigen when injected into a sensitized animal. 4. Sublethal doses of soap solutions injected simultaneously with the antigen (purified horse serum albumen) prevent anaphylactic shock. 5. The refractory state following anaphylactic shock is related in part to an increase in the antitryptic titer of the serum.
Effect of Altering Potassium Concentration on the Action of Lidocaine and Diphenylhydantoin on Rabbit Atrial and Ventricular Muscle
Authors: B. N. Singh, E. M. Vaughan Williams
Journal: Circulation Research (1971)

All previously studied antiarrhythmic drugs which also have local anaesthetic properties reduce the maximum rate of depolarization (MRD) of cardiac muscle. Recent evidence suggested that lidocaine and diphenylhydantoin (DPH) might have a different mode of action, because they did not reduce MRD except at high concentration. The latter evidence, however, was obtained from tissues nourished by solutions containing 2.7-3 m M potassium. In the present experiments, the effects of lidocaine and DPH were studied in solutions with 5.6 and 3 mM KCl. In the former, both drugs reduced MRD at concentrations similar to those found in the blood of treated patients, but in low [KCl] higher concentrations were necessary. It was concluded that there was no reason to suppose that the mode of action of lidocaine and DPH on the cardiac membrane is fundamentally different from that of quinidine, procaine, procainamide and other compounds which interfere directly with depolarization.
Jumping Frogs, Endangered Toads, and California's Medical-Marijuana Law
Authors: George J. Annas
Journal: New England Journal of Medicine (2005)

The U.S. Supreme Court recently ruled that Congress has the authority under the commerce clause to prohibit the medicinal use of homegrown marijuana, even in states, such as California, that have passed statutes permitting such use. In this article, George Annas explains the Court's rationale for its ruling and discusses the implications of the case.
Drugs Five Years Later
Authors: LOUIS LASAGNA
Journal: Annals of Internal Medicine (1976)

Propoxyphene napsylate differs from the hydrochloride salt in several ways. It is much less soluble and bitter and poses few stability problems when capsulated or tableted with aspirin. There is some evidence in several animal species that the pattern and severity of poisoning may be different with the two salts. Equimolar doses of the two salts are probably interchangeable in the relief of pain. The role of propoxyphene in clinical medicine and the questions of propoxyphene abuse and propoxyphene-related fatalities are discussed.
Survey and Biological Insights of Pemetrexed-Related Therapeutic Improvement in Mesothelioma: The Nancy Centre of Biological Resources' Mesothelioma Cohort
Authors: Fotis Vlastos, Georgios Hillas, Philippe Vidal, Stéphanie Lacomme, Françoise Galateau-Sallé, Ekkehard Vollmer, Josune Guzman-Costabel, Jean Michel Vignaud, Nadine Martinet
Journal: Journal of Thoracic Oncology (2009)
Infusion of Floxuridine in Treatment of Solid Tumors
Authors: Charles G. Moertel
Journal: JAMA (1966)

To the Editor:—  The recent article by Drs. Papac and Calabresi, Infusion of Floxuridine in the Treatment of Solid Tumors ( 197 :237, 1966) concludes that continuous infusion of floxuridine is capable of producing significant benefit to patients with gastrointestinal cancers, perhaps exceeding that from other techniques of fluorinated pyrimidine therapy, at a minimal price of toxicity. Careful review of their data, however, reveals that of the 20 patients with gastrointentinal carcinomas treated solely by continuous infusion only two, or 10%, achieved a significant response, and these responses persisted for only 6 and 12 weeks. Usual regression rates reported in the larger series of gastrointestinal cancers treated with floxuridine or fluorouracil by rapid injection are approximately 20%, with a mean duration of response of several months. In an earlier article Papac and associates reported tumor regressions in 25% of such patients treated with flowuridine by rapid injection.  In addition to the
Regional and transient ischemia/reperfusion injury in the liver improves therapeutic efficacy of allogeneic intraportal hepatocyte transplantation in low-density lipoprotein receptor deficient Watanabe rabbits
Authors: Masoumeh Attaran, Andrea Schneider, Christiane Grote, Caroline Zwiens, Peer Flemming, Klaus F. Gratz, Andrea Jochheim, Matthias J. Bahr, Michael P. Manns, Michael Ott
Journal: Journal of Hepatology (2004)
Abstract 3193: A new approach for colocalization of proteins using HRP and AP enzyme detection in paraffin embedded tissues
Authors: Rachel M. Gonzalez, Li Ding, Ming Xiao, Xiaoping Zhang
Journal: Cancer Research (2012)

Abstract Co-localization of two proteins is a powerful tool in immunofluorescence, however the stability of the fluorescence limits the ability to screen large sample sets. Double and triple staining with the ability to visualize co-localization of proteins using HRP and AP enzymes in paraffin embedded tissue may prove to be a useful tool for discovery and functional analysis of gene and protein expression. Here we present a novel chromogen mix by GBILabs.com of Emerald and Red that yields a third color (Dark Blue/Purple) when proteins are co-localized using HRP and AP enzymes for detection. Initial tests evaluated combinations of ER, Her2, CEA, Keratin, PR, p53, PCNA, and Ki67 in 10 breast and 10 colon cancer cases to screen the percentage of co-localized proteins in these cases. In addition, a 70 case breast cancer tissue array containing duplicate samples and known diagnosis of ER, PR, and Her2 for each case were screened with ER, PR, Her2, p53, PCNA, or Ki67and keratin antibodies. The core tumors sections showed co-localization of PCNA, Ki67 and p53 proteins. This new double and triple staining protocols in combination with tissue arrays, will allow researchers to rapidly determine the association between expression of two or more proteins in the tissue and if proteins co-localize within the cell. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3193. doi:1538-7445.AM2012-3193
Percutaneous balloon pericardiotomy for the treatment of cardiac tamponade and large pericardial effusions: Description of technique and report of the first 50 cases
Authors: Andrew A. Ziskind, A.Craig Pearce, Cyndi C. Lemmon, Steven Burstein, Lawrence W. Gimple, Howard C. Herrmann, Raymond McKay, Peter C. Block, Howard Waldman, Igor F. Palacios
Journal: Journal of the American College of Cardiology (1993)
Medical Interstate Reciprocity.
Authors: Emil Amberg
Journal: JAMA (1900)

Detroit, Mich., March 23. 1901. <h3>To the Editor:</h3> —In the interest of the movement aiming at interstate reciprocity for the license to practice medicine, and at uniform medical legislation, on the basis of uniform medical education, the undersigned, as member of various committees, asks all secretaries of medical boards to be kind enough to favor him with information in regard to the present status within their jurisdiction. It is especially important to know: 1, whether the respective medical law contains the reciprocity clause; 2, whether the profession in the respective political division is sufficiently familiar with the subject matters; 3. whether any amendments have been added to the law, since May, 1900, or whether there exists any intention to amend the law.
More on the Common Communion Cup
Authors: Terrance G. Furlow
Journal: Annals of Internal Medicine (1993)

Letters1 October 1993More on the Common Communion CupTerrance G. Furlow, MD and Mark J. Dougherty, MDTerrance G. Furlow, MDSearch for more papers by this author and Mark J. Dougherty, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-7_Part_1-199310010-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Sheehy that we have found no evidence establishing transmission of disease with a common communion cup. Burrows and Hemmons [1], however, did show transfer of bacteria in a laboratory setting, and this was acknowledged by Gill [2]. Nevertheless, after a century of debate [3], little field work has been done on this topic.In response to Ms. Moran, Gill's article also states that the wafer often being placed directly on their tongues by the minister must occasionally lead to the exchange of very small amounts of saliva between communicants . . Many Eucharistic ministers ...References1. Burrows W, Hemmons ES. Survival of bacteria on the silver communion cup. J Infect Dis. 1943; 73:180-90. Google Scholar2. Gill ON. The hazard of infection from the shared communion cup. J Infect. 1988; 16:3-23. Google Scholar3. Anders HS. The progress of the individual cup movement, especially among churches. JAMA. 1897; 29:789-94. Google Scholar4. Furlow TG, Dougherty MJ. Bacteria on the common communion cup. Ann Intern Med. 1993; 118:572-3. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1993Volume 119, Issue 7_Part_1Page: 638KeywordsBacteriaBreadMouthPathogensResearch laboratoriesSalivaWine Issue Published: 1 October 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes.
Authors: H Ito, Y Hirata, S Adachi, M Tanaka, M Tsujino, A Koike, A Nogami, F Murumo, M Hiroe
Journal: Journal of Clinical Investigation (1993)

To elucidate the cellular mechanism by which angiotensin II (ANG II) induces cardiac hypertrophy, we investigated the possible autocrine/paracrine role of endogenous endothelin-1 (ET-1) in ANG II-induced hypertrophy of neonatal rat cardiomyocytes by use of synthetic ET-1 receptor antagonist and antisense oligonucleotides to preproET-1 (ppET-1) mRNA. Northern blot analysis and in situ hybridization revealed that ppET-1 mRNA was expressed in cardiomyocytes, but, to a lesser extent, in nonmyocytes as well. ANG II upregulated ppET-1 mRNA level by threefold over control level as early as 30 min, and it stimulated release of immunoreactive ET-1 from cardiomyocytes in a dose- and time-dependent manner. ET-1 stimulated ppET-1 mRNA levels after 30 min in a similar fashion as ANG II. Tetradecanoylphorbol-acetate (10(-7) M) mimicked the effects of ANG II and ET-1 on induction of ppET-1 mRNA. ANG II-induced ppET-1 gene expression was completely blocked by protein kinase C inhibitor H-7 or by down-regulation of endogenous protein kinase C by pretreatment with phorbol ester. ET-1 and ANG II stimulated twofold increase [3H]leucine incorporation into cardiomyocytes, whose effects were similarly and dose dependently inhibited by endothelin A receptor antagonist (BQ123). Introduction of antisense sequence against coding region of ppET-1 mRNA into cardiomyocytes resulted in complete blockade with ppET-1 mRNA levels and [3H]leucine incorporation stimulated by ANG II. These results suggest that endogenous ET-1 locally generated and secreted by cardiomyocytes may contribute to ANG II-induced cardiac hypertrophy via an autocrine/paracrine fashion.
Differences between proximal left and right bundle branch block action potential durations and refractoriness in the dog heart.
Authors: J C Bailey, D A Lathrop, D L Pippenger
Journal: Circulation Research (1977)

To date the electrophysiological mechanism responsible for aberrant intraventricular conduction of critically timed premature supraventricular impulses has not been documented. Microelectrode techniques were used to measure in vitro action potential and refractory period durations of the canine proximal right and left bundle branches equidistant from the distal bundle of His. Both measurements in the right bundle branch were statistically significantly longer than these parameters of the left bundle branch. Transection of the bundle branches immediately distal to the distalmost recording sites effected no change in the proximal right bundle action potential but caused marked prolongation of proximal left bundle branch action potential and refractory period durations. We conclude that functional right bundle branch aberrancy is most likely due to the longer proximal right bundle action potential duration and refractoriness. Our data also suggest that the shorter proximal left bundle branch action potential durations and refractory periods may be due to the proximity of the low ohmic resistance Purkinje fiber-muscle junctions on the left septal surface, effecting electrotonic foreshortening of these proximal left bundle branch parameters.
Myocardial function of the interventricular septum. Effects of right and left ventricular pressure loading before and after pericardiotomy in dogs.
Authors: M Molaug, O Stokland, A Ilebekk, J Lekven, F Kiil
Journal: Circulation Research (1981)

We examined the function of the interventricular septum in six open-chest dogs by inserting piezoelectric crystals into the interventricular septum. Continuous ultrasonic recordings showed that the changes in myocardial chord length (MCL) in the septum and free walls of the right and left ventricle were similar during saline infusion and during pericardiotomy. End-diastolic MCL and myocardial shortening during ejection (MS) rose in the septum and free walls of both ventricles during saline infusion as end-diastolic MCL and MS in the septum and free walls of the ventricles, and reduced end-diastolic pressures by 1-2 mm Hg. The responses to aortic and pulmonary artery constrictions were similar before and after pericardiotomy. When aortic constriction had raised free left ventricular systolic pressure by about 60 mm Hg, end-diastolic MCL increased in the septum and free left ventricular wall, whereas end-diastolic MCL and MS of the free right ventricular wall fell. Pulmonary artery constriction increased end-diastolic MCL in the free right ventricular wall and reduced end-diastolic MCL and MS in the septum and free left ventricular wall. Thus, the myocardium, including the interventricular septum, is uniformly expanded during saline infusion and pericardiotomy. The interventricular septum behaves as part of the left ventricle during aortic and pulmonary artery constriction. The pericardium imposes a restraint on the interventricular septum and free walls of the ventricles during volume loading, but not during pressure loadings, because dilation of one ventricle is associated with shrinkage of the other.