tbuckley/cabot-search huggingface dataset:
USE OF BARIUM SULPHATE IN DIAGNOSIS OF COLONIC STASIS
Authors: Marks S. Shaine
Journal: JAMA (1928)

To the Editor:  —In a recent paper on Constipation: Role of the Neurogenic Factor (The Journal, Nov. 19, 1927), Boles makes the statement that normally the opaque meal should pass from the colon in approximately twenty-four   I believe that this statement is absolutely contrary to fact. In more than 95 per cent of patients the barium meal is not evacuated before forty-eight hours. When the bowel is found empty of barium at twenty-four hours there is usually obtainable a clear history of colitis. Once in a while a patient (usually one with constipation) will report that the barium, or it may be the malted milk usually given with it, acted like a cathartic, causing a number of loose movements; the roentgen-ray examination will show no barium in the colon. such cases are extremely unusual.  It would be unfortunate if the article spread the impression that the presence of barium
FATAL CASE OF LUPUS ERYTHEMATOSUS, WITH POST-MORTEM.
Authors: ROBERT GIBSON
Journal: British Journal of Dermatology (1925)

Journal Article FATAL CASE OF LUPUS ERYTHEMATOSUS, WITH POST‐MORTEM. Get access ROBERT GIBSON, M.D. ROBERT GIBSON, M.D. Hon. Dermatologist, Salford Royal Hospital; Hon. Assistant Physician, Manchester and Salford Hospital for Diseases of the Skin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 37, Issue 5, 1 May 1925, Pages 232–233, https://doi.org/10.1111/j.1365-2133.1925.tb09950.x Published: 01 May 1925
Anti-SOX2 T cells may prevent myeloma
Authors: Hema Bashyam
Journal: The Journal of Experimental Medicine (2007)

The immune system can only prevent cancer if it recognizes and destroys precancerous cells. Antigenic targets of such an early immune response, however, have been elusive. Spisek et al. (page 831) now find that an embryonic stem cell marker is a bull's eye for immune cells in patients who have precancerous lesions but never develop multiple myeloma.






Figure 1

Patients who have anti-SOX2 T cells (solid line) are less likely to develop multiple myeloma than those lacking these T cells (dashed line).




Multiple myeloma is an incurable cancer that occurs throughout the bone marrow. It is caused by the uncontrolled proliferation of antibody-producing B cells, which replace normal immune cells as well as red blood cells and platelets. In some patients, this malignant cancer is preceded by a benign condition known as multiple gammopathy of undetermined significance (MGUS). During this stage, the abnormal B cells do not form tumors, and the patients remain healthy. Although MGUS occurs in ∼3% of the population over 50 years of age, only a third of those with MGUS will eventually develop myeloma.

This selective disease protection, the team now shows, correlates with the presence of immune responses against the embryonic transcription factor SOX2. SOX2 is normally switched off after embryonic stem cells differentiate, but, in both MGUS and myeloma patients, it is reactivated in bone marrow cells that are potential tumor progenitors. MGUS patients had anti-SOX2 antibodies and T cells, but the myeloma patients did not. In a two-year observational study, patients with early tumors who had anti-SOX2 T cells remained cancer-free. Those that lacked these T cells, however, developed multiple myeloma.

These findings suggest that an immune response against the SOX2-expressing bone marrow cells may prevent malignancy. The group is now trying to determine whether myeloma patients never mount an immune response to SOX2 or simply lose it over time. The group's in vitro evidence suggests that anti-SOX2 T cells prevent tumor formation. But myeloma patients would have to be vaccinated against SOX2 to confirm that these T cells have antitumor activity in vivo.
Illuminating the Antrum
Authors: Marvin H. Sleisenger
Journal: New England Journal of Medicine (1979)

Atrophic gastritis consists of chronic inflammation and atrophy of the gastric mucosa. As the atrophy of gastric glands progresses, particularly in pernicious anemia, a heavy cellular infiltrate of lymphocytes and plasma cells persists.1 The circumstances leading to atrophic gastritis are not clear. Some cases begin as superficial gastritis, but in many the disease starts and progresses silently.2 Although acute and chronic superficial gastritis are associated with peptic-ulcer disease, severe physical stress, ingestion of alcohol and salicylates or reflux of bile into the stomach (in benign gastric ulcer and after antrectomy), these factors are not commonly implicated in the pathogenesis of . . .
Recovery of cutaneous immune responsiveness after PUVA therapy
Authors: S.I. WHITE, P.S. FRIEDMANN, C. MOSS, J.M. SIMPSON
Journal: British Journal of Dermatology (1988)

We studied sensitization to dinitrochlorobenzene (DNCB) in psoriatic patients before, during and 2, 4, and 6 weeks after a course of photochemotherapy (PUVA). The inhibition of sensitivity observed during PUVA was completely reversed after 6 weeks. Thus the PUVA-mediated inhibition of cutaneous immune responsiveness is of short duration. However, whether there are long-term sequelae remains to be established.
411. Trapping of Adenovirus Vectors in Blood
Authors: Daniel Stone, Shaoheng Ni, Zong-Yi Li, Dmitry M. Shayakhmetov, Andre Lieber
Journal: Molecular Therapy (2005)

In an attempt to circumvent the limitations of Adenovirus (Ad) vectors derived from group C serotype Ad5 we recently developed vectors based on group B serotype Ad11. These vectors are benefited by the low prevalence of Ad11-neutralizing antibodies in humans, and the CD46-dependent tropism of Ad11. CD46 is expressed at high levels in cell types including hematopoietic stem cells, dendritic cells and metastatic tumor cells. Following systemic intravenous delivery of an Ad5 vector, a chimeric Ad5 vector possessing the CD46 interacting Ad11 fiber (Ad5/11), and an Ad11 vector to CD46 transgenic mice we discovered that the kinetics of vector clearance from blood are different. Using real time quantitative PCR to detect viral genomes we found that the number of Ad11 vector genomes in mouse serum at 3 minutes post tail vein injection was 2 orders of magnitude lower than for Ad5 and Ad5/11 vectors, but at 15 and 120 minutes post injection the number of vector genomes was comparable between Ad5, Ad5/11 and Ad11. To investigate the differences between the numbers of vector genomes in serum at 3 minutes post injection the association of vector genomes with blood cells was also monitored by real time quantitative PCR at all time points. The number of vector genomes associated with blood cells was more than one order of magnitude higher for Ad11 than Ad5 or Ad5/11 at all time points tested with the highest difference seen at 3 minutes post injection (|[sim]|2 orders of magnitude higher). To study which type of blood cells associate with Ad11 vectors, CD46 transgenic mice were injected in the tail vein with 3H-[thymidine] labeled Ad vector. Individual cell types were separated from blood collected at 3 minutes post injection and the highest levels of tritium labeled Ad11 were associated with the platelet fraction. Subsequent analyses revealed that Ad5, Ad5/11 and Ad11 vectors associate with platelets within minutes after intravenous injection but that Ad11 vectors associate at higher levels. Electron microscopic analysis of platelets isolated 3 minutes after injection of Ad5, Ad5/11 or Ad11 vectors revealed that Ad particles were associated with the platelet surface and structures of the surface-connected canalicular system. We also noticed that Ad11 vectors associate with mononuclear cells more efficiently than Ad5/11 vectors. When taken together, the observations that Ad11 associates with platelets and mononuclear cells more efficiently than Ad5/11 suggests that capsid proteins other than fiber may mediate blood cell interactions. We are currently investigating the mechanism(s) by which Ad capsids and blood cells interact. The roles of the serotype specific (Ad5 or Ad11) capsid proteins hexon, penton and fiber in Ad/blood cell interactions will be presented. Our aim is to develop new Ad vectors that are not trapped in blood upon systemic intravascular administration.
A 29-Year-Old Man With Multiple Sclerosis, 1 Year Later
Authors: Thomas L. Delbanco
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Holiday Lectures Bring Tidings of Good Science
Authors: Joan Stephenson
Journal: JAMA (1997)

EACH December for the past 5 years, some of the country's most respected biomedical scientists have opened a window on their worlds to high school students in a series of "holiday lectures"—an event modeled after a tradition begun by the 19th-century English chemist and physicist Michael Faraday. This year, with a series named (with a nod to Jane Austen) "Sense and Sensitivity: Neuronal Alliances for Sight and Sound," 2 leading neuroscientists asked students to consider just what goes on in their brains when they see and hear. In 4 one-hour lectures, the speakers, A. James Hudspeth, PhD, MD, of The Rockefeller University, New York, NY, and Jeremy H. Nathans, MD, PhD, of The Johns Hopkins University School of Medicine, Baltimore, Md, explored the biological mechanisms that underlie the senses and enable humans and other organisms to detect and process stimuli such as sights and sounds. In previous years, Howard
A CRITICISM OF SOME OF THE THEORIES REGARDING THE ETIOLOGY OF GOUNDOU AND AINHUM.
Authors: F. C. WELLMAN
Journal: JAMA (1906)

incumbent on us, as teachers and practitioners of sur- gery, to make it plain to the public that there is a ma- terial difference between the trained surgeon and the novice?This education will enable the public to dis- criminate in a wholesome manner and will ultimately have the effect of rendering it apparent to the candidate
Dopamine-receptor stimulation: biobehavioral and biochemical consequences
Authors: Frédéric Calon, Abdallah Hadj Tahar, Pierre J. Blanchet, Marc Morissette, Richard Grondin, Martin Goulet, Jean-Pierre Doucet, George S. Robertson, Eric Nestler, Thérèse Di Paolo, Paul J. Bédard
Journal: Trends in Neurosciences (2000)
The Theory and Practice of Infant Feeding, with Notes on Development.
Authors: Henry Dwight Chapin, H W. b. Conn
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2 Are patients satisfied with a teledermatology consultation?
Authors: R. Stockley, J. English, A. Morris, R. Emerson
Journal: British Journal of Dermatology (2002)

Background Many dermatologists have expressed concerns about the development of teledermatology. It is a radical shift from the traditional face-to-face consultation with the dermatologist as the GP takes digital images of the patient's skin condition and emails them with the history to the consultant dermatologist for his or her opinion. The dermatologist emails the opinion back to the GP who then informs the patient. The objective of this study was to see if the patients who had undergone a teledermatology consultation were satisfied with the service. This was an attempt to involve patients in the decision-making process regarding the development of a new health care service. Methods A postal questionnaire was sent to the first 180 patients of the teledermatology pilot service. 114 (64% response rate) were returned, 52 (46%) of patients did not require a hospital attendance and 62 (54%) did. Questionnaire Prefer to use the telederm service or wait to see the dermatologist face to face? Prefer to wait for hospital consultation rather than use the telederm service if this meant a much longer wait? Would you use the telederm service again? Satisfied or very satisfied with the telederm service (had to choose one of five options) Did NOT require hospital visit 64% yes 21% yes 98% yes 80% Did require hospital visit 49% yes 19% yes 87% yes 64% Results and Conclusions There were some differences in the responses between those patients that required a hospital visit and those that did not. A traditional face-to-face consultation would have been preferred by 20% of patients . The patients that did attend hospital seemed to have a preference for traditional face-to-face consultation compared those that did not attend hospital but nearly 90% of all patients returning the questionnaire would use the service again.
Krill powder increases liver lipid catabolism and reduces glucose mobilization in tumor necrosis factor-alpha transgenic mice fed a high-fat diet
Authors: Bodil Bjørndal, Rita Vik, Trond Brattelid, Natalya Filipchuk Vigerust, Lena Burri, Pavol Bohov, Ottar Nygård, Jon Skorve, Rolf K. Berge
Journal: Metabolism (2012)
Sudden Cardiac Death and Genetic Ion Channelopathies
Authors: Carlo Napolitano, Raffaella Bloise, Nicola Monteforte, Silvia G. Priori
Journal: Circulation (2012)

udden cardiac death is a common outcome of several cardiac disorders such as acute myocardial ischemia, myocardial infarction, and heart failure.2][3] In 1997, a panel of experts defined sudden death in the absence of an identifiable cause as idiopathic ventricular fibrillation (IVF): "IVF is the terminology that best acknowledges our current inability to identify a causal relationship between the clinical circumstance and the arrhythmia." 4 In the same article, the requirements for the diagnosis of IVF were identified on the basis of the clinical tools available at the time.In 1992, using the phenotypes observed in the IVF registry, we advanced the hypothesis that IVF could be the manifestation of concealed forms of arrhythmogenic disorders 5 exacerbated by appropriate triggers.A few years later, the discovery of the genes of long-QT syndrome (LQTS) 6 -8 and the detection of incomplete penetrance 9 supported this early hypothesis.Incomplete penetrance and variable expressivity in inherited arrhythmogenic disorders imply that the distinctive ECG patterns that characterize these disorders may be concealed. 10Interestingly, however, the absence of the ECG markers of the disease is not an indicator of favorable outcome, as demonstrated by the evidence that the incidence of cardiac arrest in LQTS patients with normal QTc during the first 40 years of life is Ϸ4%, ie, 0.1%/y. 11,124][15][16][17][18][19][20] Although the yield of molecular autopsy reported by different studies is highly variable, ranging from 4% to 30%, it is sufficient to prove the concept that ion channel mutations may underlie IVF and that a positive genetic test may allow the extension of genotyping to family members of those affected to reduce additional deaths in the family. Clinical Manifestations and ManagementLQTS diagnosis should be considered in all patients presenting with QTc Ͼ440 milliseconds in male patients and
Pegylated poly-l-arginine derivatives of chitosan for effective delivery of siRNA
Authors: Sang Myoung Noh, Myung Ok Park, Gayong Shim, Su Eun Han, Han Young Lee, Jun Hyuk Huh, Myoung Suk Kim, Jin Joo Choi, Kwangmeyung Kim, Ick Chan Kwon, Jin-Seok Kim, Kwang-Hyun Baek, Yu-Kyoung Oh
Journal: Journal of Controlled Release (2010)
TCT-368 Preclinical validation of light intensity analysis on Optical Coherence tomography to monitor bioresorption and integration process after implantation of a bioresorbable scaffold in porcine model: a comparison between OCT and Histology
Authors: Shimpei Nakatani, LAURA E. Perkins, YUKI ISHIBASHI, Richard Rapoza, Yoshinobu Onuma, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2014)
SANITARY LESSONS OF THE WAR.
Authors: GEORGE M. STERNBERG
Journal: JAMA (1899)

As compared with the Civil War and with other great wars during the present century, the mortality from wounds and disease among our troops during the war with Spain has been low. Our wounded have, to a large extent, had the advantage of prompt treatment with antiseptic dressings and a very considerable proportion of those who were not killed outright have recovered without any mutilating operation or septic complication. The mortality from disease has also been comparatively low, but unfortunately during the first months of the war, that scourge of new levies of new troops—typhoid fever—prevailed in many of our camps and claimed numerous victims. It is well known to sanitarians and military surgeons that as a general rule more soldiers succumb to disease than are killed by the bullets of the enemy, and our recent war has not been an exception in this regard. The total number of deaths
Role of Exercise Test in Evaluation of Cardiac Patients
Authors: Robert M. Levenson
Journal: JAMA (1963)

PHYSICIANS ARE CONCERNED with functional capacity when they deal with cardiac patients. This is especially true in the advising of such patients about work in which accurate assessment is important. The functional classification of a cardiac patient is ordinarily determined by history. In taking the history, the clinician learns from the patient's statement what activities he can perform and what activities he feels will induce symptoms presumably of cardiac origin. Such a history should ordinarily include an evaluation of specific activities. Commonly, these include the climbing of steps or hills of specified distances, taking into consideration the rate of performing these, as well as the patient's accustomed activity level. The clinician will assign a functional classification, based on these remarks. This is best done by using the New York Heart Association classification of 1 to 4 and, as well, the therapeutic classification, letters A to D<sup>'</sup>(Table 1). In the
Abstract ES6-2: Evolving Trends in Implant Breast Reconstruction
Authors: A Pusic
Journal: Cancer Research (2012)

Abstract For women undergoing mastectomy, implant breast reconstruction is increasingly common. Over the past 5 years, new trends in implant reconstruction have been evolving. The use of ‘next-generation’ silicone implants, acellular dermal matrices and fat grafting have expanded the range of options available to patients. In addition, for women undergoing both skin-sparing and nipple-sparing mastectomies, there is growing experience with single-stage implant reconstruction (i.e. implant placement directly at the time of mastectomy without use of a tissue expander). Finally, indications for post-mastectomy radiation continue to increase and this has important implications for long-term patient satisfaction with implant reconstruction. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr ES6-2.
Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
Authors: Frederic A. Carvalho, Omry Koren, Julia K. Goodrich, Malin E.V. Johansson, Ilke Nalbantoglu, Jesse D. Aitken, Yueju Su, Benoit Chassaing, William A. Walters, Antonio González, Jose C. Clemente, Tyler C. Cullender, Nicolas Barnich, Arlette Darfeuille-Michaud, Matam Vijay-Kumar, Rob Knight, Ruth E. Ley, Andrew T. Gewirtz
Journal: Cell Host & Microbe (2012)
Baxter’s The Foot and Ankle in Sport
Authors: Joseph A. Bosco
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A conversation with Harold Varmus
Authors: Ushma S. Neill
Journal: Journal of Clinical Investigation (2012)

For the first of our series Conversations with Giants in Medicine, we spoke with Harold Varmus, who has been the director of the National Cancer Institute since July 2010 (Figure ​(Figure1).1). He has previously served as director of the National Institutes of Health (1993–1999) and as president of the Memorial Sloan-Kettering Cancer Center (2000–2010). Among his many awards, Varmus was awarded the 1989 Nobel Prize in Physiology or Medicine together with J. Michael Bishop in recognition of their discovery of the cellular origin of retroviral oncogenes. The full interview can be seen on the JCI website, http://www.jci.org/kiosk/cgm.