tbuckley/cabot-search huggingface dataset:
Abstract P5-03-13: ASPM as a link between mammary tissue architectures, Wnt signaling pathways, breast cancer stemness and aggressiveness
Authors: KK-C Tsai
Journal: Cancer Research (2013)

Abstract Disruption of tissue microarchitectures represents an early step of tumorigenesis and the related molecular events may have important biological and clinical implications. Using a physiologically relevant model of tissue organization, we exploited the ubiquitous transcriptomic change associated with human glandular morphogenesis, thereby identifying a microcephaly-related gene ASPM that reciprocally links to mammary tissue architectures. We show that ASPM was functionally indispensible for the structural transformation of differentiated mammary acini and its depletion in breast carcinoma cells forced reversion of malignant tumor architectures. In vitro and in vivo functional assays, together with clinical correlative analysis, revealed that ASPM is an oncogenic factor that carries strong, independent and robust prognostic significance in breast cancer. Follow-on biochemical and functional studies demonstrated that ASPM serves as a scaffolding protein for upstream activators of beta-catenin, including notably dishevelled-2, whereby it regulates Wnt signaling pathways, cytoskeleton and cell locomotion. Interestingly, through its effect on the Wnt pathway activity, ASPM also critically regulate a subpopulation of breast cancer stem cells (CSCs) that exhibited high migratory potentials in vitro. Consistently, silencing of ASPM in breast CSCs attenuated the tumor growth and distant metastasis in mouse xenograft models of human breast cancer. Together, our results provide a novel mechanistic link between tissue architecture, Wnt signaling, breast cancer stemness and tumor aggressiveness (Supported in part by grants CA-101-PP-19 from National Health Research Institutes and DOH 102-TD-C-111-004 from Department of Health, Taiwan to K.K.T.). Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-03-13.
Regulation of Th2 Cell Differentiation by mel-18, a Mammalian Polycomb Group Gene
Authors: Motoko Kimura, Yoko Koseki, Masakatsu Yamashita, Naohiro Watanabe, Chiori Shimizu, Takuo Katsumoto, Toshio Kitamura, Masaru Taniguchi, Haruhiko Koseki, Toshinori Nakayama
Journal: Immunity (2001)
Bovine Somatotropin-Reply
Authors: Charles J. Grossman
Journal: JAMA (1991)

<h3>In Reply.—</h3> Dr Gilchrist has proposed a number of concerns that, I believe, should be addressed in order. He makes the blanket statement to the effect that the editorial attempted to justify the use of bST in the American dairy industry. This is not the case except as it relates to the human health issue and milk safety. The editorial was written expressly to sort out and place in perspective for the general public the conflicting and erroneous information clouding this whole area. If bST increases the rate of small farm failure, this would be a very unfortunate aspect of its use. However, it is not clear at this time what the economic impact will actually be, given the fact that the dairy industry was in grave trouble long before bST was in evidence. While bST may not benefit the small farmer, who may unfortunately already be on a downward
Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis
Authors: P-T Yang, H Kasai, W-G Xiao, L-J Zhao, L-M He, A Yamashita, X-W Deng, M Ito
Journal: Annals of the Rheumatic Diseases (2006)

Increasing evidence suggest that macrophage colony-stimulating factor (M-CSF) plays a part in rheumatoid arthritis, but few studies have focused on its role in ankylosing spondylitis. This study aimed at investigating M-CSF expression and its clinical significance in active ankylosing spondylitis and rheumatoid arthritis.

Sandwich ELISA was used to measure serum M-CSF levels in 12 active patients with ankylosing spondylitis (Bath Ankylosing Spondylitis Disease Activity Index of ⩾3)1 and 12 active patients with rheumatoid arthritis.2 Eleven serum samples of healthy volunteers were examined as controls. We also examined M-CSF mRNA expression in peripheral blood mononuclear cells (PBMCs) using real-time reverse transcription-polymerase chain reaction. The relative fold increase in M-CSF mRNA expression in patient groups was determined by 2−ΔΔC.3 Considering that tumour necrosis factor (TNF) α and interleukin (IL) 1α have the ability to induce M-CSF,4 we also investigated their levels and correlations with M-CSF. …
Mutant Wilms’ tumor 1 (WT1) mRNA with premature termination codons in acute myeloid leukemia (AML) is sensitive to nonsense-mediated RNA decay (NMD)
Authors: S Abbas, C A J Erpelinck-Verschueren, C S Goudswaard, B Löwenberg, P J M Valk
Journal: Leukemia (2009)
Promotion of cell proliferation and inhibition of ADCC by cancerous immunoglobulin expressed in cancer cell lines
Authors: Ming Li, Hui Zheng, Zhi Duan, Haidan Liu, Duosha Hu, Ann Bode, Zigang Dong, Ya Cao
Journal: Cellular and Molecular Immunology (2011)

To explore the significance of cancerous immunoglobulin (Ig) in cancer cell growth, HeLa cervical cancer cells were stably transfected with small interfering RNA (siRNA) that specifically, efficiently and consistently silences the expression of heavy chain genes of all immunoglobulin isotypes. This stable cell line was used to examine cell viability, colony formation and tumor growth in athymic nude mice. The results of these experiments indicated that siRNA-mediated knockdown of cancerous Ig inhibited cell growth in vitro and suppressed tumor cell growth in immune-deficient nude mice in vivo. Similarly, this siRNA also inhibited the growth of MGC gastric cancer cells and MCF-7 breast cancer cells. Furthermore, the presence of cancerous Ig specifically reduced antibody-dependent cell-mediated cytotoxicity (ADCC) induced by an anti-human epithelial growth factor receptor (EGFR) antibody in a dose-dependent manner, suggesting that the cancerous Ig-Fc receptor interaction inhibits natural killer cell (or NK cell) effector function. The prevalent expression of Ig in human carcinomas and its capacity to promote growth and inhibit immunity might have important implications in growth regulation and targeted therapy for human cancers.
Tunnel Vision in Pesticide Control
Authors: Henry F. Howe
Journal: JAMA (1973)

Peripheral blindness to the secondary effects of its regulations is a frequent peculiar characteristic of government. An outstanding example of this phenomenon is the current situation triggered by Environmental Protection Agency Administrator William D. Ruckelshaus' decision of June 14, 1972, to cancel all DDT registrations except those for public health and quarantine uses, and for export. The order goes into effect after Dec 31, 1972. This regulation, which effectively abolishes US agricultural use of the organochlorine DDT for all except a few minor crops (onions, sweet potatoes, and green peppers, if need for the pesticide can be proved at hearings) is a culmination of social and political pressures that have represented DDT as the chief chemical villain in the modern environmentalist movement. This it almost certainly is not. But much worse, the organophosphate insecticides, which will usually now be substituted for DDT, may prove to be the real villains. It
Acute Inflammatory Polyradiculoneuropathy Following Hymenoptera Stings
Authors: David S. Bachman
Journal: JAMA (1982)

Five patients had a neurological syndrome develop beginning three to ten days after Hymenoptera insect stings. Three had typical acute inflammatory polyradiculoneuropathy (Guillain-Barré syndrome). A fourth was similar, except that seizures developed, and the fifth patient showed only cranial nerve involvement and hyporeflexia. The timing of these neurological manifestations following insect stings suggests the possibility of a direct or indirect cause-and-effect relationship. (<i>JAMA</i>1982;247:1443-1445)
Drug Testing of Physicians
Authors: David Orentlicher
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tobacco 21 — An Idea Whose Time Has Come
Authors: Jonathan P. Winickoff, Mark Gottlieb, Michelle M. Mello
Journal: New England Journal of Medicine (2014)

Starting in May 2014, it will be illegal in New York City to sell tobacco products and e-cigarettes to persons younger than 21 years of age. Further dissemination of “Tobacco 21” laws represents a critical opportunity for public health law to reduce a major health risk.
De subitaneis mortibus. XV. Hereditary stenosis of the His bundle in Pug dogs.
Authors: T N James, B T Robertson, A L Waldo, C E Branch
Journal: Circulation (1975)

Syncope and sudden death occurs in certain purebred Pug dogs which have been found to have intermittent sinus pauses and paroxysmal second degree heart block on electrocardiographic (ECG) study. We have established a colony of such dogs to study this problem and here report the results of histological examination of the cardiac conduction system in twenty-one of them. These include a dam which may be considered the proband, three of her offspring (two littermates) and three fetal pups in an unborn litter of one of these; three of the four adult dogs died suddenly and unexpectedly. Two groups of puppies descendants of these lines were also studied after they all died within three days of birth. The first group of puppies (8) did not have suitable ECG studies but the second group (6) did and showed ECG changes similar to those in the adult dogs. In all 21 dogs the sinus node was anatomically normal, but in every one there was significant stenosis of the midportion of the His bundle. There was no abnormality of the atrioventricular (A-V) node or of the bundle branches, and the cardiac valves and coronary arteries were normal. Two pups had ventricular septal defects and one of these had an atrial defect as well. All the dogs were of the normal fawn color, had a normal physical appearance and no visible evidence of associated extracardiac abnormalities. The adult dogs were able to hear normally but the puppies died too early to test their hearing. The paroxysmal heart block may in part be attributable to the abnormality in the His bundle, but other factors possibly leading to heart block and long sinus pauses are discussed. Stenosis of the midportion of the His bundle appears to be a heritable trait in these purebred Pug dogs.
Synergistic induction of PI-PLCβ1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes
Authors: M Y Follo, C Finelli, S Mongiorgi, C Clissa, F Chiarini, G Ramazzotti, S Paolini, G Martinelli, A M Martelli, L Cocco
Journal: Leukemia (2010)
A Prospective Study of Anger and Coronary Heart Disease
Authors: Ichiro Kawachi, David Sparrow, Avron Spiro, Pantel Vokonas, Scott T. Weiss
Journal: Circulation (1996)

Background Recent laboratory and epidemiological studies have suggested that high levels of anger may increase the risk of coronary heart disease (CHD). Methods and Results We examined prospectively the relationship of anger to CHD incidence in the Veterans Administration Normative Aging Study, an ongoing cohort of older (mean age, 61 years) community-dwelling men. A total of 1305 men who were free of diagnosed CHD completed the revised Minnesota Multiphasic Personality Inventory (MMPI-2) in 1986. Subjects were categorized according to their responses to the MMPI-2 Anger Content Scale, which measures the degree to which individuals have problems controlling their anger. During an average of 7 years of follow-up, 110 cases of incident CHD occurred, including 30 cases of nonfatal myocardial infarction (MI), 20 cases of fatal CHD, and 60 cases of angina pectoris. Compared with men reporting the lowest levels of anger, the multivariate-adjusted relative risks among men reporting the highest levels of anger were 3.15 (95% confidence interval [CI]: 0.94 to 10.5) for total CHD (nonfatal MI plus fatal CHD) and 2.66 (95% CI: 1.26 to 5.61) for combined incident coronary events including angina pectoris. A dose-response relation was found between level of anger and overall CHD risk ( P for trend, .008). Conclusions These data suggest that high levels of expressed anger may be a risk factor for CHD among older men.
Transactions of XI International Medical Congress.
Authors: Augustus P. Clarke.
Journal: JAMA (1896)

Cambridge, Mass., Jan. 20, 1896.  To the Editor:  — In the Miscellany of theJournalof January 18, page 142, inquiry is made as to what time the volumes of the XIth International Medical Congress at Rome, Italy, will be ready for distribution.  In answer, I would say that I received some months ago direct from Messrs. Rosenberg & Sellier, Libreria Internazionale, Via Bogino 3, Torino, Italy, volume ii, and on January 18, through the Bureau of International Exchanges, Smithsonian Institution, Washington, D. C., volumes iii and iv.  For members to receive their volumes promptly it will be necessary to make remittance of 7.50 francs to the house of Rosenberg & Sellier, Libreria Internazionale, Via Bogino 3, Torino, Italy, to meet the expenses of the distribution.  Sincerely yours,
Chief medical officer warns against complacency over swine flu
Authors: R. Coombes
Journal: BMJ (2009)

The health secretary, Alan Johnson, and the chief medical officer for England, Liam Donaldson, have told the public not to become complacent about A/H1N1 flu and have warned that the hallmarks of a pandemic are still present.

As news of the novel virus enters its third week, the signs are that the UK government’s policy of containment—including the closure of four schools—is working. The latest figures put the number of infected people in the United Kingdom at 34. No evidence has yet been shown in the UK of sustained, person to person transmission of the virus.

Worldwide the number of cases has risen to 1518, with 29 confirmed deaths in Mexico; but in the House of Commons on Thursday 7 May …
Just another Sunday
Authors: T. J Stannard
Journal: BMJ (1998)

I write this one Sunday evening having just finished a centre based session for our local cooperative, which has now been established for just over a year.

One patient in particular sticks in my mind. She was a temporary resident staying with her parents for the weekend and 30 weeks advanced in this her, so far uncomplicated, second pregnancy. Before leaving home she had experienced some mild suprapubic discomfort and frequency but thought little of it. On the Sunday morning the symptoms had worsened and now she had obvious symptoms of a urinary tract infection. She had telephoned our helpline on the Sunday morning, been offered an appointment, and asked to bring a specimen. When I saw her, in the comfort of a consulting room, her urine had been “dipsticked” (confirming the presence of leucocytes, nitrites, and protein), and a midstream urine specimen organised. She left me with a prescription to deal with her urinary tract infection. …
Screening for Carotid Artery Stenosis: An Update of the Evidence for the U.S. Preventive Services Task Force
Authors: Tracy Wolff, Janelle Guirguis-Blake, Therese Miller, Michael Gillespie, Russell Harris
Journal: Annals of Internal Medicine (2007)

Background: Cerebrovascular disease is the third leading cause of death in the United States. The proportion of all strokes attributable to previously asymptomatic carotid artery stenosis (CAS) is low. In 1996, the U.S. Preventive Services Task Force concluded that evidence was insufficient to recommend for or against screening of asymptomatic persons for CAS by using physical examination or carotid ultrasonography. Purpose: To examine the evidence of benefits and harms of screening asymptomatic patients with duplex ultrasonography and treatment with carotid endarterectomy for CAS. Data Sources: MEDLINE and Cochrane Library (search dates January 1994 to April 2007), recent systematic reviews, reference lists of retrieved articles, and suggestions from experts. Study Selection: English-language randomized, controlled trials (RCTs) of screening for CAS; RCTs of carotid endarterectomy versus medical treatment; systematic reviews of screening tests; and observational studies of harms from carotid endarterectomy were selected to answer the following questions: Is there direct evidence that screening with ultrasonography for asymptomatic CAS reduces strokes? What is the accuracy of ultrasonography to detect CAS? Does intervention with carotid endarterectomy reduce morbidity or mortality? Does screening or carotid endarterectomy result in harm? Data Extraction: All studies were reviewed, abstracted, and rated for quality by using predefined Task Force criteria. Data Synthesis: No RCTs of screening for CAS have been done. According to systematic reviews, the sensitivity of ultrasonography is approximately 94% and the specificity is approximately 92%. Treatment of CAS in selected patients by selected surgeons could lead to an approximately 5–percentage point absolute reduction in strokes over 5 years. Thirty-day stroke and death rates from carotid endarterectomy vary from 2.7% to 4.7% in RCTs; higher rates have been reported in observational studies (up to 6.7%). Limitations: Evidence is inadequate to stratify people into categories of risk for clinically important CAS. The RCTs of carotid endarterectomy versus medical treatment were conducted in selected populations with selected surgeons. Conclusion: The actual stroke reduction from screening asymptomatic patients and treatment with carotid endarterectomy is unknown; the benefit is limited by a low overall prevalence of treatable disease in the general asymptomatic population and harms from treatment.
OBSERVATIONS ON FLAGELLAR AND SOMATIC AGGLUTINATION
Authors: John B. Nelson
Journal: The Journal of Experimental Medicine (1928)

Whole, shaken and heated suspensions of two Salmonella species were compared as to agglutinability, absorptive capacity and antigenic properties. The results were in general agreement with the flagellar antigen concept of Smith and Reagh. The removal of flagella by shaking or heating (100 degrees C.) resulted in altered agglutinability manifested by failure to give a floccular reaction with "whole" antiserum. The deflagellated bacteria were able to absorb some flocculating agglutinin from that serum. They were unable, however, to produce flocculating agglutinin upon injection in rabbits. Untreated, shaken and heated suspensions of a non-motile bacterium (Staphylococcus) showed no differences with respect to agglutinability or absorptive capacity. Soluble precipitable material was found present in small amount in culture filtrates of the motile bacteria and in greater concentration in filtrates of heated suspensions. The bulk of the soluble material was of somatic origin and was not appreciably increased by the presence of flagella. It was possible, however, to demonstrate soluble material in heated flagellar suspensions. The relation of such soluble substances to floccular agglutination and the production of flocculating agglutinin as suggested by Hadley is discussed.
Pain as Human Experience: An Anthropological Perspective
Authors: Jeffrey M. Borkan
Journal: JAMA (1993)

The authors of this innovative selection of essays provide new insights into a prevalent and challenging subject: chronic pain. Pain causes endless suffering, alters lives, frustrates health care providers, and costs untold billions of dollars. Although pain is ubiquitous to the human experience, it remains enigmatic in terms of its diagnosis, pathophysiology, natural history, and treatment. Pain, particularly in its chronic forms, challenges the biomedical model, since it obscures the traditional border between mind and body, objective and subjective, real and unreal, physical and psychosocial. This book contains research on the experiences of chronic pain in the American sociocultural context. The researchers conducted long interviews among patients with various types of chronic pain and undertook participant observations at a residential pain clinic in New England. Their findings go beyond the old ethnic stereotypes of pain behavior (for instance, that Italians are more expressive and Yankees more withholding) to examine the
Quality of drainage blood: Survival of red cells after re-transfusion and content of free hemoglobin and potassium
Authors: Christoph Buchta, Beatrice Hanslik-Schnabel, Roman Weigl, Jana List, Günther F. Körmöczi, Maria Macher, Harald Heinzl, Paul Höcker, Axel Wanivenhaus, Martin Kurz
Journal: International Journal of Surgery (2005)
IgG subclass serum levels in juvenile chronic arthritis.
Authors: A Martini, A Plebani, A Ravelli, M.A Avanzini, R Jefferis, L Zonta, L.D Notarangelo, A.G Ugazio, R Burgio
Journal: Annals of the Rheumatic Diseases (1986)

IgG subclass levels of sera from 26 patients with juvenile chronic arthritis (JCA) were determined by means of mouse monoclonal antibodies. Patients were divided into three groups according to clinical activity of the disease: active disease, partial remission, and remission. One hundred and sixty four age matched, healthy children served as controls. IgG subclass concentrations were log transformed, and a robust regression method was applied to obtain expected values for the different ages. We found a significant increase of IgG3 (p less than 0.0001), IgG1 (p less than 0.002), and IgG2 (p less than 0.035) in JCA sera, while IgG4 values did not differ significantly from those of controls. When patients were divided according to clinical activity significant increases of IgG2 and IgG4 were observed in the patients in partial remission. Our data suggest that differential increase of IgG subclasses during the courses of JCA may be of relevance to the pathogenesis of the disease.