Enterovirus in the Chronic Fatigue Syndrome
Authors: Frances McGarry
Journal: Annals of Internal Medicine (1994)

Letters1 June 1994Enterovirus in the Chronic Fatigue SyndromeFrances McGarry, BSc, John Gow, PhD, and Peter O. Behan, MDFrances McGarry, BScSouthern General Hospital; Glasgow G51 4TF; Scotland, John Gow, PhDSouthern General Hospital; Glasgow G51 4TF; Scotland, and Peter O. Behan, MDSouthern General Hospital; Glasgow G51 4TF; ScotlandAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-11-199406010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The chronic fatigue syndrome is a recurring illness of unknown cause characterized by incapacitating fatigue and a range of symptoms and laboratory findings suggestive of hypothalamic dysfunction [1-3]. Rare patients who have died from other acute causes have had cellular infiltrates in the hypothalamus [4]. The syndrome usually follows a flu-like illness, and circumstantial evidence has implicated enteroviruses [1]. We therefore examined the central nervous system of a woman with the syndrome who died from suicide for the presence of enterovirus.In June 1992, a 30-year-old woman who had met all criteria for the syndrome for 5 ...References1. Bakheit AM, Behan PO, Watson WS, Morton JJ. Abnormal arginine-vasopressin secretion and water metabolism in patients with postviral fatigue syndrome. Acta Neurol Scand. 1993; 87:234-8. Google Scholar2. Bakheit AM, Behan PO, Dinan TG, Gray CE, O'Keane V. Possible upregulation of hypothalamic 5-HT receptors in patients with the postviral fatigue syndrome. Br Med J. 1992; 304:1010-2. Google Scholar3. Demitrak MA, Dale JK, Straus SE. Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. J Clin Endocrinol Metab. 1991; 73:1224-34. Google Scholar4. Crowley N, Nelson M, Stouin S. Epidemiological aspects of an outbreak of encephalomyelitis at the Royal Free in the summer of 1955. J Hygiene. 1957; 55:116. Google Scholar Author, Article, and Disclosure InformationAffiliations: Southern General Hospital; Glasgow G51 4TF; Scotland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAutoimmune complications of COVID‐19Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent SymptomsThe Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical ReviewChronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)Enteroviruses and Human Neuromuscular DiseasesPacing as a strategy to improve energy management in myalgic encephalomyelitis/chronic fatigue syndrome: a consensus documentRéactivité microbienne lymphocytaire dans le syndrome de fatigue chronique et la fibromyalgieLearning to cope with chronic illness. Efficacy of a multi-component treatment for people with chronic fatigue syndromeThe Enteroviruses: An Emerging Infectious Disease? The Real, the Speculative and the Really SpeculativeImmunoglobulin subclass levels in chronic fatigue syndromeViruses and Chronic Fatigue SyndromeViral illness and chronic fatigue (syndrome) 1 June 1994Volume 120, Issue 11Page: 972-973KeywordsBrainChronic fatigue syndromeEnterovirusHypothalamusMyocardiumPolymerase chain reactionRNASequence analysisSpleenSuicide Issue Published: 1 June 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...