Risk of Human Immunodeficiency Virus Infection from Blood Donors Who Later Developed the Acquired Immunodeficiency Syndrome
Authors: JOHN W. WARD
Journal: Annals of Internal Medicine (1987)

Brief Reports1 January 1987Risk of Human Immunodeficiency Virus Infection from Blood Donors Who Later Developed the Acquired Immunodeficiency SyndromeJOHN W. WARD, M.D., DEBORAH A. DEPPE, B.S., SUSAN SAMSON, M.P.H., HERBERT PERKINS, M.D., PAUL HOLLAND, M.D., LEONOR FERNANDO, M.D., PAUL M. FEORINO, Ph.D, PAUL THOMPSON, M.D., STEVEN KLEINMAN, M.D., JAMES R. ALLEN, M.D.JOHN W. WARD, M.D.Search for more papers by this author, DEBORAH A. DEPPE, B.S.Search for more papers by this author, SUSAN SAMSON, M.P.H.Search for more papers by this author, HERBERT PERKINS, M.D.Search for more papers by this author, PAUL HOLLAND, M.D.Search for more papers by this author, LEONOR FERNANDO, M.D.Search for more papers by this author, PAUL M. FEORINO, Ph.DSearch for more papers by this author, PAUL THOMPSON, M.D.Search for more papers by this author, STEVEN KLEINMAN, M.D.Search for more papers by this author, JAMES R. ALLEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-1-61 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBlood transfusions can transmit the human immunodeficiency virus (HIV; formerly HTLV-III/LAV), the etiologic agent of the acquired immunodeficiency syndrome (AIDS). Because serologic tests to identify HIV-infected persons were not commercially available until 1985, previous studies of HIV transmission via blood transfusion first identified transfusion-associated cases of AIDS and then, retrospectively, the respective blood donors (1-3). The blood donors implicated in HIV transmission have usually been asymptomatic at the time of donation but become viremic years after their donation (4). Thus, previous studies of transfusion-associated HIV infection could not assess the likelihood of HIV transmission from infected donors to recipients.As...References1. CURRANLAWRENCEJAFFE JDH. Acquired immunodeficiency syndrome (AIDS) associated with transfusions. N Engl J Med. 1984;310:69-75. CrossrefMedlineGoogle Scholar2. PETERMANJAFFEFEORINO THP. Transfusion-associated acquired immunodeficiency syndrome in the United States. JAMA. 1985;254:2913-7. CrossrefMedlineGoogle Scholar3. FEORINOKALYANARAMANHAVERKOS PVH. Lymphadenopathy associated virus infection of a blood donor-recipient pair with acquired immunodeficiency syndrome. Science. 1984;225:69-72. CrossrefMedlineGoogle Scholar4. FEORINOJAFFEPALMER PHE. Transfusion-associated acquired immunodeficiency syndrome: evidence for a persistent infection in blood donors. N Engl J Med. 1985;312:1293-6. CrossrefMedlineGoogle Scholar5. . Revision of the case definition of acquired immunodeficiency syndrome for national reporting—United States. MMWR. 1985;34:373-5. MedlineGoogle Scholar6. TSANGPERALTASIMONS VJA. Enzyme-linked immunoelectrotransfer blot techniques (EITB) for studying the specificities of antigens and antibodies separated by gel electrophoresis. In: LANGONE JJ, VUNAKIS HV, eds. Methods in Enzymology: Immunochemical Techniques. New York: Academic Press; 1983:377-91. Google Scholar7. CLOPPERPEARSON CE. The use of confidence or fiducial limits illustrated in the case of the binomial. Biometrika. 1934;26:404-6. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN W. WARD, M.D.; DEBORAH A. DEPPE, B.S.; SUSAN SAMSON, M.P.H.; HERBERT PERKINS, M.D.; PAUL HOLLAND, M.D.; LEONOR FERNANDO, M.D.; PAUL M. FEORINO, Ph.D; PAUL THOMPSON, M.D.; STEVEN KLEINMAN, M.D.; JAMES R. ALLEN, M.D.Affiliations: Centers for Disease Control Atlanta, Georgia Irwin Memorial Blood Bank San Francisco Sacramento Medical Foundation Blood Center Sacramento American Red Cross Blood Services Los Angeles, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBlood as a Vehicle for the Spread of AIDSEpidemiology and Prevention of Acquired Immunodeficiency Syndrome and Human Immunodeficiency Virus InfectionHuman Immunodeficiency Virus in Health Care SettingsHuman Immunodeficiency Viruses Types 1 and 2Infectious Agents Transmitted by TransfusionBlood system changes since recognition of transfusion-associated AIDSUrologic Aspects of AIDS and HIV InfectionPreventing occupational HIV infection in the health-care environmentEpidemiology and Prevention of Acquired Immunodeficiency Syndrome and Human Immunodeficiency Virus InfectionHuman Immunodeficiency Virus in Health Care SettingsGeneral Principles of InfectionTrends in Major Transfusion-transmissible Infections among Blood Donors over 17 Years in Istanbul, TurkeyThree stage AIDS incubation period: a worst case scenario using addict–needle interaction assumptionsImmune activation in HIV-infected African individualsForecasting Methods for HIV/AIDS and AgingSteady-state calculation of the risk of HIV infection from transfusion of screened blood from repeat donorsRetroviruses—Human Immunodeficiency VirusHIV disease and its treatment: current status and future prospectsInfections and immunological hazards of allogeneic bone transplantationRisks for Exposures to and Infection with HIV among Health Care Providers in the Emergency DepartmentThe Changing Epidemiology of Human Immunodeficiency Virus Infection in Older PersonsHIV Disease: Current ConceptsEpidemiology of AIDS in females with hemophilia and other chronic bleeding disorders in the united states: Comparisons with males with chronic bleeding disorders and AIDS and with nonhemophilic female blood-transfusion recipients with AIDSPsycho-social aspects of HIV infection and AIDS in multiple transfused thalassemic childrenHuman Immunodeficiency Virus Infection in ChildrenPRODUCT PROCESS VALIDATION WITH HUMAN IMMUNODEFICIENCY VIRUS-IHuman Immunodeficiency Virus Infection in PregnancyHuman Immunodeficiency Virus (HIV) Infections in the United StatesTransmission of Human Immunodeficiency Virus Type 1 (HIV-1) by Exposure to Blood: Defining the RiskRobert S. Klein, MD, Gerald H. Friedland, MDInfection with Human Immunodeficiency Virus Type 1 (HIV-1) among Recipients of Antibody-Positive Blood DonationsElizabeth Donegan, MD, Maria Stuart, MPH, Joyce C. Niland, PhD, Henry S. Sacks, MD, PhD, Stanley P. Azen, PhD, Shelby L. Dietrich, MD, Cheryl Faucett, MS, Mary Ann Fletcher, PhD, Steven H. Kleinman, MD, Eva A. Operskalski, PhD, Herbert A. Perkins, MD, Johanna Pindyck, MD, Eugene R. Schiff, MD, Daniel P. Stites, MD, Peter A. Tomasulo, MD, James W. Mosley, MD, Transfusion Safety GroupHuman immunodeficiency virus, AIDS, and organ transplantationRisks of TransfusionAIDS: an overviewThe epidemiology of HIV infection and AIDSTransfusion-Associated HIV InfectionHuman Immunodeficiency Virus (HIV) Infection and the KidneyRichard J. Glassock, MD, Arthur H. Cohen, MD, Gabriel Danovitch, MD, K. Peter Parsa, MDHow Safe is the Blood Supply in the United States?Human Immunodeficiency Virus Variation and Epidemiology of Acquired Immunodeficiency Syndrome and Human Immunodeficiency Virus InfectionAIDS-Manifestationen bei Hämophilen -Ergebnisse der Bonner Studiengruppe für HIV-Infektion und Hämophilie 1982–19891 Clinical picture and managementInfections Acquired Through Blood TransfusionAIDS: Overview, immunology, virology, and informational needsThe Natural History of Transfusion-Associated Infection with Human Immunodeficiency VirusStatistical analysis of the stages of HIV infection using a Markov modelThe Integration of HIV Testing and Counseling into Nursing PracticeImmunoglobulin Preparations for HIV-Infected PatientsIncidence of symptoms and AIDS in 146 Swedish haemophiliacs and blood transfusion recipients infected with human immunodeficiency virus.Silent Sequences and the Safety of Blood TransfusionsTHOMAS F. ZUCK, M.D.Acquisition and Transmission of HIVPediatric HIV Infection Etiopathogenesia and TransmissionTransfusion Associated AIDSTransmission of Human Immunodeficiency Virus (HIV) by Blood Transfusions Screened as Negative for HIV AntibodyEpidemiology of HIV Infection and AIDS in the United StatesInactivation of HIV and Safety Precautions for the WorkplaceEpidemiologie der HIV-InfektionHIV-Infektion und BlutspendewesenHuman immunodeficiency virus infection and the acquired immune deficiency syndrome: A reviewThe problem of human immunodeficiency virus (HIV) infection and transplantationTransmission of the Human Immunodeficiency Virus 1 January 1987Volume 106, Issue 1Page: 61-62KeywordsAIDSBlood donorsBlood transfusionEpidemiologyHIVHIV infectionsRetrospective studies ePublished: 1 December 2008 Issue Published: 1 January 1987 PDF downloadLoading ...