Prolactinomas in Women: Current Therapies
Authors: Alan G. Robinson, Paul B. Nelson
Journal: Annals of Internal Medicine (1983)

Editorials1 July 1983Prolactinomas in Women: Current TherapiesALAN G. ROBINSON, M.D., PAUL B. NELSON, M.D.ALAN G. ROBINSON, M.D.Search for more papers by this author, PAUL B. NELSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-1-115 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince prolactin was shown by Kleinberg and Frantz (1) to be a hormone separate from human growth hormone and since the development of radioimmunoassays for prolactin (2), the diagnosis of hyperprolactinemia as a cause of galactorrhea and amenorrhea has become common. Among unscreened women with amenorrhea, 15% to 25% may have elevated levels of prolactin; if one preselects for galactorrhea, the incidence is even higher (3).Normally prolactin is under chronic suppression by dopamine, released from the hypothalamus. Prolactin secretion can be inhibited by pharmacologic agents that mimic the effect of dopamine (levodopa, bromocriptine, pergolide mesylate), and stimulated by direct...References1. KLEINBERGFRANTZ DA. Human prolactin: measurement in plasma by in vitro bioassay. J Clin Invest. 1971;50:1557-68. CrossrefMedlineGoogle Scholar2. HWANGGUYDAFRIESEN PHH. A radioimmunoassay for human prolactin. Proc Natl Acad Sci USA. 1971;68:1902-6. CrossrefMedlineGoogle Scholar3. GREERMORACZEWSKIRAKOFF MTJ. Prevalence of hyperprolactinemia in anovulatory women. Obstet Gynecol. 1980;56:65-9. MedlineGoogle Scholar4. TURKSOYFARBERMITCHELL RMG Diagnostic and therapeutic modalities in women with galactorrhea. Obstet Gynecol. 1980;56:323-9. MedlineGoogle Scholar5. BOYDREICHLINTURKSOY ASR. Galactorrhea-amenorrhea syndrome: diagnosis and therapy. Ann Intern Med. 1977;87:165-75. LinkGoogle Scholar6. KAMOITCHUCHIDASATO KIH. 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Author, Article, and Disclosure InformationAffiliations: University of Pittsburgh Pittsburgh, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEfficacy and tolerability of a long-acting intramuscularly injectable depot preparation of bromocriptine: the results of a double blind studyGiant invasive prolactinomasLong-acting bromocriptine for the acute treatment of large macroprolactinomasProlactin-Secreting TumorsHormone Assays in Endocrine SystemManagement of Pituitary TumorsVisual Function in Prolactinoma Patients Treated with BromocriptineLONG-TERM BROMOCRIPTINE THERAPY MAY RESTORE THE INHIBITORY CONTROL OF PROLACTIN RELEASE IN SOME PATIENTS WITH PATHOLOGICAL HYPERPROLACTINEMIAPituitary TumorsDrugs Five Years Later BromocriptineMARY LEE VANCE, M.D., WILLIAM S. EVANS, M.D., MICHAEL O. THORNER, M.B.Controversies in the treatment of endocrine tumors: medical and surgical management of prolactinomas, acromegaly and thyroid cancer 1 July 1983Volume 99, Issue 1Page: 115-118KeywordsDopamineGrowth hormoneHuman growth hormoneHypothalamusLevodopaProlactinRadioimmunoassaysResearch grants Issue Published: 1 July 1983 PDF DownloadLoading ...