tbuckley/cabot-search huggingface dataset:
Treatment of echinococcosis.
Authors: P Bouree, R Molimard
Journal: BMJ (1978)

This was shown in the survey referred to earlier as well as in Dr Tomlin's study.With the routine use of ventilators the use of low-flow rebreathing systems with carbon dioxide absorption appears to be diminishing.The higher gas flows employed are adding to the pollution.In addition flowmeters and vaporisers often remain open in anaesthetic rooms long after the patient has gone back to the ward via the operating theatre.The problem of pollution is perhaps well recognised now.The current shortage of anaesthetists is putting more stress on the available people and perhaps forcing them to face the pollution for longer periods.It must be even more so in Birmingham!
Hospital chaplaincy services are not only for religious patients
Authors: M. Newitt
Journal: BMJ (2009)

At the age of 25 Adrian Sudbury, a local newspaper journalist, was given a diagnosis of acute myeloid leukaemia. I first met Adrian in early 2007 in my role as a hospital chaplain and worked with him over the next 18 months, ending up helping him plan his funeral and memorial service. Many of the particulars of my work with Adrian related to wider themes about the role and value of chaplaincy in the NHS. Adrian was not religious, yet he was certain that chaplaincy interventions greatly contributed to his wellbeing. His case typifies a new generation of patients who require a shift in knowledge, skills, and practice by all those involved in the holistic care of patients.

In the early months of Adrian’s chemotherapy we met on several occasions for general conversation. When I visited in May 2007 he told me he was now in hospital for a stem cell transplantation, and I spent time listening to Adrian express mixed emotions about the transplantation. He was glad there was a donor but was concerned about being in isolation and was, unsurprisingly, worried about the unknown outcome and future. During Adrian’s five weeks in isolation I visited him nine times. When Adrian was feeling the effects of the treatment, …
The Ammonia Tolerance Test: An Index of Portal Hypertension.
Authors: Donald O. Castell
Journal: Annals of Internal Medicine (1965)

s1 November 1965The Ammonia Tolerance Test: An Index of Portal Hypertension.Donald O. CastellDonald O. CastellSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-909_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDivers investigators have proposed that the oral ammonia tolerance test can be utilized to evaluate the presence of portal-systemic collateral circulation in patients with hepatic cirrhosis. In addition, it has been shown that there is a high degree of association between collateral circulation and portal hypertension. This study was under-taken to evaluate the correlation between the abnormal oral ammonia tolerance test and portal hypotension in patients with cirrhosis of the liver.The arterial ammonia tolerance test was studied in 18 patients with hepatic cirrhosis, and the results were compared with the portal pressure as measured by hepatic vein wedge pressure.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC USN Great Lakes, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 909-909KeywordsAmmoniaCirrhosisHypotensionLiverPortal hypertensionVeins Issue Published: 1 November 1965 PDF DownloadLoading ...
Carbon dioxide and pulsed dye laser treatment of angiofibromas in 29 patients with tuberous sclerosis
Authors: E. Papadavid, A. Markey, G. Bellaney, N.P.J. Walker
Journal: British Journal of Dermatology (2002)

Summary Background Data on the benefits, adverse effects and appropriate types of laser treatment for angiofibromas (AF) in patients with tuberous sclerosis (TS) are limited. Objectives To evaluate the efficacy and side-effect profile of carbon dioxide (CO2) 10 600 nm wavelength and flashlamp-pumped pulsed dye (FLPDL) 585 nm wavelength lasers in a retrospective study of 29 patients with TS aged 9–48 years. Methods Long-term results, based on clinical improvement of the vascular, fibrous or protuberant types of AF and the presence or absence of side-effects on follow-up visits, were classified as excellent, moderate or poor. Results Results were excellent in most patients with vascular-type AF treated with one or two sessions of FLPDL, but some required up to six treatment sessions. CO2 lasers produced excellent results with considerable long-term improvement in 10 of 13 (77%) patients with fibrous or protuberant AF, specifically in all (three of three) protuberant and 70% (seven of 10) of fibrous AF. Persistent hypertrophic scarring was seen in three of 13 (23%) patients with either fibrous or protuberant AF treated with the continuous wavelength CO2 laser. Treatment with both lasers used in four patients with combined vascular and non-vascular AF components was excellent in three of four (75%) patients. Significant relapse was seen in one patient treated with the CO2 laser. Conclusions CO2 or FLPDL laser treatment should be considered as an effective treatment for patients with disfiguring TS. A combination of lasers may be required to achieve optimal results.
Nonabandonment: Medical Ethics
Authors: John R. Lindquist
Journal: Annals of Internal Medicine (1995)

Letters15 September 1995Nonabandonment: Medical EthicsJohn R. Lindquist, MDJohn R. Lindquist, MDGlenbrook Hospital; Glenview, IL 60025Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-6-199509150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent paper, Quill and Cassel [1] emphasized that nonabandonment was a necessary component of the physician–patient relationship. In an accompanying editorial, Dr. Pellegrino [2] discussed and refuted the issue of elevating this concept to the status of an ethical principle.I believe that both papers neglected time and responsibility as more important variables meriting further discussion. The physician–patient relationship is by nature longitudinal and potentially vulnerable in this evolving managed care era. Patients seem to acknowledge this more than physicians do, and the choice of physicians seems to remain a non-negotiable item in health care ...References1. Quill TE, Cassel CK. Nonabandonment: a central obligation for physicians. Ann Intern Med. 1995; 122:368-74. Google Scholar2. Pellegrino ED. Nonabandonment: an old obligation revisited [Editorial]. Ann Intern Med. 1995; 122:377-8. Google Scholar3. Agich GJ, Youngner SJ. For experts only? Access to hospital ethics committees. Hastings Cen Rep. 1991; 21:17-24. Google Scholar Author, Article, and Disclosure InformationAffiliations: Glenbrook Hospital; Glenview, IL 60025 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIn Search of a Theory of Budgeting: A Literature Review 15 September 1995Volume 123, Issue 6Page: 473KeywordsComputersHealth careMedical ethicsResidency Issue Published: 15 September 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 4680: Correlation between Wnt pathway and colorectal cancer recurrence using protein, mRNA and microRNA analysis
Authors: Renata A. Coudry, Mila O. Martins, Cláudia M C Coutinho, Marcilei Buim, Kátia C. Carvalo, Erika M. Santos, Helena Brentani
Journal: Cancer Research (2010)

Abstract BACKGROUND: Wnt signaling pathway has a fundamental role in colorectal carcinogenesis. However, few studies have focused in the association of this pathway and the risk of postoperative recurrence. Besides microRNAs repress protein translation through binding to targets mRNAs and have shown association with specific targets. The main goal of this study was to evaluate several members of Wnt signaling pathway (Wnt protein family, proteins from β-catenin/APC complex, transcription factors and target proteins) and CRC recurrence. We also would like to assess association of microRNAs with specific Wnt targets or the direct implication of those small non coding RNAs with CRC recurrence. METHODS: The expression of Wnt proteins and mRNAs were assessed using immunohistochemistry and Real Time-PCR techniques, respectively. We also studied 381 microRNAs using Low Density TaqMan Array. This study was performed in samples from patients presenting stages I and II CRC and comparing those who had recurrence to those who did not. All patients undergone surgery with curative intention from 2000 to 2006 in A. C. Camargo Hospital. Statistical analyses used in this study were Chi-square, exact Fisher's test and T Paired. RESULTS: Regarding the protein expression and gene expression of Wnt signaling members only c-Myc showed statistically significant association with recurrence (p=0,001 and p=0,048, respectively). Regarding the analysis of 381 microRNAs, a statistically significant association was observed for miR-197 (p=0,03), where the group of patients who did not had recurrence demonstrated higher expression levels of this microRNA when compared to the group of patients who developed tumor recurrence. CONLUSION: Increased levels of c-Myc expression and low levels of miR-197 in the tumor may be used at the time of primary removal for defining patients at risk for tumor recurrence. miR-197 may regulate indirectly the expression of c-Myc. However, further experiments will be required to better evaluate this hypothesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4680.
Application of controlled high dose rates in UV-B phototherapy for psoriasis
Authors: A. A. SCHOTHORST, J. BOER, D. SUURMOND, C. A. C. KENTER
Journal: British Journal of Dermatology (1984)

Journal Article Application of controlled high dose rates in UV‐B phototherapy for psoriasis Get access A. A. SCHOTHORST, A. A. SCHOTHORST Department of Dermatology, University Hospital Leiden, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar J. BOER, J. BOER Department of Dermatology, University Hospital Leiden, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar D. SUURMOND, D. SUURMOND Department of Dermatology, University Hospital Leiden, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar C. A. C. KENTER C. A. C. KENTER Department of Dermatology, University Hospital Leiden, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 110, Issue 1, 1 January 1984, Pages 81–87, https://doi.org/10.1111/j.1365-2133.1984.tb07316.x Published: 01 January 1984 Article history Accepted: 23 June 1983 Published: 01 January 1984
The Physicians' Sanitarium.
Authors: C. H. Hughes
Journal: JAMA (1894)

San Francisco, June 8, 1894. <h3>To the Editor:</h3> There is an error in the announcement of the Physicians' Sanitarium which appeared in your issue of May 5 and possibly in subsequent issues. I am not connected with that institution in that or any other capacity. While I did contemplate connecting myself with that enterprise and deem such an institution, conducted on ethical lines, a proper enterprise in which physicians might and should engage, I declined permitting my name to be used in connection therewith upon seeing a circular emanating from a business manager thereof, and though the circulars have since been withdrawn I have yet no connection with that institution. I make this statement with no intention to reflect upon the present management of the said institution, which I believe to be now ethically conducted. Respectfully,
Reviving the Conversation Around CPR/DNR
Authors: Jeffrey P. Bishop, Kyle B. Brothers, Joshua E. Perry, Ayesha Ahmad
Journal: The American Journal of Bioethics (2010)

This paper examines the historical rise of both cardiopulmonary resuscitation (CPR) and the do-not-resuscitate (DNR) order and the wisdom of their continuing status in U.S. hospital practice and policy. The practice of universal presumed consent to CPR and the resulting DNR policy are the products of a particular time and were responses to particular problems. In order to keep the excesses of technology in check, the DNR policies emerged as a response to the in-hospital universal presumed consent to CPR. We live with this historical concretion, which seems to perpetuate a false culture that the patient's wishes must be followed. The authors are critical of the current U.S. climate, where CPR and DNR are viewed as two among a panoply of patient choices, and point to UK practice as an alternative. They conclude that physicians in the United States should radically rethink approaches to CPR and DNR.
Aneuploidy of Chromosome 9 and the Tumor Suppressor Genes p16&lt;sup&gt;INK4&lt;/sup&gt; and p15&lt;sup&gt;INK4B&lt;/sup&gt; Detected by in situ Hybridization in Locally Advanced Prostate Cancer
Authors: Birgit Heidenreich, Axel Heidenreich, Andreas Sesterhenn, Shiv Srivastava, Judd W. Moul, Isabell A. Sesterhenn
Journal: European Urology (2000)
Abstract P2-11-15: Development of a web-based survey tool to assess change in breast cancer (BrCa) survivor knowledge after receipt of cancer treatment summary and survivorship care plan (SCP).
Authors: JL Custer, GB Rocque, KB Wisinski, NR Jones, S Donohue, TM Koehn, TL Champeny, AR Terhaar, KB Chen, KA Peck, MT Tun, DA Wiegmann, ME Sesto, AJ Tevaarwerk
Journal: Cancer Research (2012)

Abstract Intro: The Institute of Medicine advocates survivorship care plans (SCPs) as tools to improve coordination of care by improving survivor knowledge of follow-up recommendations and future risks. No evidence exists to demonstrate that SCPs impact survivor knowledge of diagnosis, treatment, or future/chronic side effects. Furthermore, there is a lack of information on existing surveys and their ability to assess survivor knowledge regarding these issues, without change over time. The purpose of this research is to report on the development of a survey assessing knowledge of diagnosis, treatment, and side effects in BrCa survivors. Methods: Using existing literature, two oncologists created 24 questions addressing knowledge of diagnosis, treatment, and side effects. Content experts including breast oncology providers (representing multiple subspecialties), Survey Research Shared Service (SRSS) and patient advocates reviewed and revised the questions. Next, potential questions were administered in a group setting to BrCa survivors to evaluate clarity of instructions and survey wording. The Breast Cancer Knowledge (BreaCK) survey was further revised based on survivor feedback. For pilot testing, BrCa survivors were recruited from clinic to test BreaCK survey content and clarity. Survey 1 was administered in clinic online. SRSS conducted verbal assessments regarding content after Survey 1. Four weeks later, survivors received Survey 2 via email and answered online. Correct answers were abstracted from the medical record. Results: Nine subjects completed both surveys. Qualitatively, little intra-subject variation was seen between surveys. Subjects did not feel that the survey was burdensome or intrusive. No subject was able to correctly answer all questions. Final survey adjustments were made based on subject feedback and common incorrect answers encountered when grading the surveys. Specifically, subjects had difficulty understanding “endocrine or hormone therapy.” Furthermore, subjects reported guessing in response to some questions – additional answer categories were added, including “I don't know.” Conclusion: Survivor knowledge did not change significantly between surveys. This suggests survivor knowledge was not impacted by the survey over the four-week interval. The revised BreaCK survey may be a useful tool for assessing survivor knowledge of diagnosis, treatment and side effects. A larger cohort of BrCa survivors is being recruited, starting Summer 2012, and will be evaluated using the survey. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-11-15.
Tc-99m MIBI Brain SPECT in the Diagnosis of Recurrent Glioma
Authors: CHAN H. PARK, SUNG M. KIM, JAMES J. ZHANG, CHARLES M. INTENZO, JACK R. McEWAN
Journal: Clinical Nuclear Medicine (1994)

A 30-year-old woman with clinically suspected recurrent glioma was evaluated by brain SPECT using Tc-99m methoxyisobutylisonitrile (MIBI). Three areas of Tc-99m MIBI uptake correlated well with suspicious recurrence noted on MRI.
The Cyclooxygenase-2–Prostaglandin E<sub>2</sub>Pathway Maintains Senescence of Chronic Obstructive Pulmonary Disease Fibroblasts
Authors: Maylis Dagouassat, Jean-Marie Gagliolo, Sandra Chrusciel, Marie-Claude Bourin, Corinne Duprez, Philippe Caramelle, Laurent Boyer, Sophie Hue, Jean-Baptiste Stern, Pierre Validire, Dan Longrois, Xavier Norel, Jean-Luc Dubois-Randé, Sabine Le Gouvello, Serge Adnot, Jorge Boczkowski
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Rationale: Chronic obstructive pulmonary disease (COPD) is associated with lung fibroblast senescence, a process characterized by the irreversible loss of replicative capacity associated with the secretion of inflammatory mediators. However, the mechanisms of this phenomenon remain poorly defined.Objectives: The aim of this study was to analyze the role of prostaglandin E2 (PGE2), a prostaglandin known to be increased in COPD lung fibroblasts, in inducing senescence and related inflammation in vitro in lung fibroblasts and in vivo in mice.Methods: Fibroblasts were isolated from patients with COPD and from smoker and nonsmoker control subjects. Senescence markers and inflammatory mediators were investigated in fibroblasts and in mice.Measurements and Main Results: Lung fibroblasts from patients with COPD exhibited higher expression of PGE2 receptors EP2 and EP4 as compared with nonsmoker and smoker control subjects. Compared with both nonsmoker and smoker control subjects, during long-term culture, COPD fibroblasts displayed increased senescent markers (increased senescence associated-β galactosidase activity, p16, and p53 expression and lower proliferative capacity), and an increased PGE2, IL-6, IL-8, growth-regulated oncogene (GRO), CX3CL1, and matrix metalloproteinase-2 protein and cyclooxygenase-2 and mPGES-1 mRNA expression. Using in vitro pharmacologic approaches and in vivo experiments in wild-type and p53−/− mice we demonstrated that PGE2 produced by senescent COPD fibroblasts is responsible for the increased senescence and related inflammation. PGE2 acts either in a paracrine or autocrine fashion by a pathway involving EP2 and EP4 prostaglandin receptors, cyclooxygenase-2–dependent reactive oxygen species production and signaling, and consecutive p53 activation.Conclusions: PGE2 is a critical component of an amplifying and self-perpetuating circle inducing senescence and inflammation in COPD fibroblasts. Modulating the described PGE2 signaling pathway could provide a new basis to dampen senescence and senescence-associated inflammation in COPD.
The effect of graded coronary flow reduction in the left anterior descending and septal arteries on left ventricular function in the canine heart.
Authors: Y Koiwa, T Nunokawa, N Ishide, S Isoyama, S Kitaoka, K Tamaki, S Satoh, H Suzuki, Y Shimizu, Y Kakuta, E Ino-Oka, T Takishima
Journal: Circulation (1980)

WE quantitatively analyzed the effect of graded left anterior descending and septal coronary flow (LAD + septal flow) reduction on left ventricular function with a left ventricular end-diastolic pressure (LVEDP) of 6 mm Hg and 12 mm Hg. We used an isolated, ejecting, canine heart preparation ( n = 8), the coronary flow of which could be controlled independently of the aortic pressure. We kept the other hemodynamic variables - heart rate, left circumflex coronary flow, right coronary flow and aortic input impendance - constant within their normal physiologic range. We considered this reduction in LAD + septal flow to be analogous to that of the most frequent lesion in ischemic heart disease. There was no plateau in the left ventricular work caused by this reduction of the regional coronary flow. Therefore, the plateau commonly reported in previous studies may be partially a result of the compensatory elevation of LVEDP, which is necessary to maintain the left ventricular work.
A piece of my mind. Deserted island
Authors: J. W. Burnside
Journal: JAMA (1991)

I have a fantasy about a deserted island. This island is temperate, is well provisioned with water, fruits, and vegetables, and perhaps has good fishing. A safe place but no communications, no people, maybe a dog or a goat, and no way off save by a visiting ship once a twelvemonth. In this fantasy I have control of the residency requirements and the passenger manifest of the visiting steamer. I can write the prescription, which reads: Rx: One deserted island One year Sig: As directed No refills While I'm at it, and since this is fantasy, let me have as many of these islands as needed, since I'd have trouble were I forced to choose among the many who might benefit. Such a prescription could be life-giving, even lifesaving. A kind of Statue of Liberty for the weak, tired, and dizzy, for the yearning souls eager to be cocooned lest
The often overlooked digital tuft: clues to diagnosis and pathophysiology of neuropathic disease and spondyloarthropathy
Authors: B M Rothschild
Journal: Annals of the Rheumatic Diseases (2005)

To assess diagnostic implications of abnormalities of the pedal digital tufts and to identify features to facilitate distinguishing of spondyloarthropathy and leprosy.Better criteria for distinguishing between these disorders are necessary if their character, natural history, and evolution are to be understood.Pedal x rays of 91 consecutive patients with diabetes, 21 alcoholic patients, 100 with spondyloarthropathy, 8 with scleroderma, and 137 with leprosy, and 188 defleshed skeletons of individuals with alcoholism, syphilis, cerebrovascular disease, and paraplegia from the Terry and Hamman-Todd collections were examined for evidence of osseous and articular pathologies. Digital tuft abnormalities were divided into irregularity, divot, flattening, resorption, whittling, and fragmentation.Tuft divots were more common in alcoholics than in diabetic, and were more common in both than in the other groups studied. Tuft flattening was limited to alcoholic and neurosyphilis groups. Tuft whittling was especially prominent among individuals with spondyloarthropathy, contrasted with leprosy and diabetes. Aligned fractures were more common in diabetics than individuals with leprosy. Misaligned fractures were limited to individuals with leprosy and neurosyphilis. Leprosy and spondyloarthropathy were complicated by phalangeal and metatarsal whittling more commonly than other diseases studied. Background pedal abnormalities, derived from individuals with cardiovascular syphilis, cerebrovascular accidents, and paraplegia, was limited to abnormal divots only.Pedal digital tufts undergo a variety of pathological alterations useful in the recognition of disorders traditionally considered neuropathic in aetiology and in distinguishing differential considerations. Tuft flattening appears specific for alcoholism and neurosyphilis, and misaligned fractures seem specific for neurosyphilis and leprosy, providing differential assistance related to spondyloarthropathy. Conversely, periosteal reaction distinguishes spondyloarthropathy from leprosy.
Genetic inheritance of Gilbert's syndrome
Authors: PiterJ Bosma, Jayanta Roy Chowdhury, PeterH.M Jansen, Hiroshi Sato, Yukihiko Adachi, Sachiko Aono, Eiichiro Uyama, Tatsuo Nanno, Hiroomi Keino, Yasukazu Yamada, Osamu Koiwai
Journal: The Lancet (1995)