tbuckley/cabot-search huggingface dataset:
Motorway Madness — On the House — Poor Ephraim
Authors: John Lister
Journal: New England Journal of Medicine (1972)

THE term "motorway madness" has been applied to the behavior of drivers who continue driving at high speed in fog on motorways. Many accidents have occurred in such conditions, the worst so far, occurring recently on the Ml motorway when 50 vehicles piled up in the south-bound lanes and another 20 piled up in the north-bound lanes. Eight people died, and 45 were injured in these crashes, which happened when fog cleared and then suddenly returned to a previously sunlit stretch of road. As a result of mounting concern at such accidents, the Transport Minister has arranged for talks with . . .
Safety and efficacy of brentuximab vedotin for Hodgkin lymphoma recurring after allogeneic stem cell transplantation
Authors: Ajay K. Gopal, Radhakrishnan Ramchandren, Owen A. O'Connor, Robert B. Berryman, Ranjana H. Advani, Robert Chen, Scott E. Smith, Maureen Cooper, Achim Rothe, Jeffrey V. Matous, Laurie E. Grove, Jasmine Zain
Journal: Blood (2012)
Mouse Model for Atherosclerotic Plaque Rupture
Authors: Mark W. Majesky
Journal: Circulation (2002)

upture of advanced human atherosclerotic plaques can precipitate coronary thrombosis, myocardial infarction, and sudden death, but insights into the causes and treatment of plaque rupture have been hampered by lack of a suitable animal model.Particularly desirable would be a model of plaque rupture that would take advantage of current and forthcoming mouse mutant alleles.It is therefore of considerable interest that the study by von der Thüsen et al 1 in this issue of Circulation reports the characterization of a model of induced plaque rupture in apolipoprotein E-deficient (ApoE Ϫ/Ϫ ) mice secondary to cap thinning produced by overexpression of p53, a proapoptotic stimulus for plaque smooth muscle cells (SMCs).
Postoperative legionella pneumonia diagnosed by percutaneous lung aspiration.
Authors: M K Benson, R G Mitchell, M Phillips
Journal: BMJ (1981)

in our patient, however, occurred in the absence of such stimulation.Myoclonus as defined by Gastaut3 may occur as a result of any lesion from the motor cortex to the spinal motor neurone, but these movements were not myoclonic in our patient.The patient described by Campbell and Garland1 with subacute myoclonic spinal neuronitis had more rapid myoclonus in the legs associated with fever and possible spinal cord infarction.Our patient's involuntary movements fit Hughlings Jackson's description of focal epilepsy.'Nittner5 states that epileptic seizures are rarely caused by spinal cord tumours but reviewing the case reports he found these seizures restricted to patients with tumours around the foramen magnum.Gowers5 cites Brown-Sequard's comment that "spinal epilepsy" is a suitable description for a violent muscle spasm followed by clonic movements occurring in a patient with a known spinal cord lesion.There is no other published description of spinal epilepsy with such a clear focal motor event occurring in a patient with a spinal lesion.Immediate cessation of these attacks after the removal of the meningioma emphasised the cause and effect relation.We acknowledge the help of Mr S G Galbraith, who performed the laminectomy, Dr E Teasdale, who performed the radiology, and Mrs M McColl for secretarial work.
The syndrome of chronic photosensitivity dermatitis and actinic reticuloid
Authors: W. FRAIN-BELL, T. LAKSHMIPATHI, J. ROGERS, JOYCE WILLOCK
Journal: British Journal of Dermatology (1974)

In a Study of thirty‐four male subjects suffering from the syndrome of chronic photosensitivity dermatitis and actinic reticuloid the clinical, histological and photobiological features were such as to suggest that they were in fact examples of a single entity in which the degree of response to ultraviolet and visible light varied. Although a wide action spectrum involving UV and visible wavelengths invariably occurred with the classical clinical and histological features of actinic reticuloid (Ive et al., 1969) a broad action spectrum with similar histological appearances was also noted in some of the subjects in whom the morphological changes were those of a chronic dermatitis confined to exposed sites.
Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web-based questionnaire survey
Authors: S. Takeuchi, J. Oba, H. Esaki, M. Furue
Journal: British Journal of Dermatology (2014)

Journal Article Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web‐based questionnaire survey Get access S. Takeuchi, S. Takeuchi Department of Dermatology Graduate School of Medical Sciences Kyushu University 3‐1‐1 Maidashi Higashi‐ku Fukuoka 812‐8582 JapanDepartment of Dermatology Federation of National Public Service Personnel Mutual Aid Associations Hamanomachi Hospital 3‐3‐1 Nagahama Chuo‐ku Fukuoka 810‐8539 Japan Search for other works by this author on: Oxford Academic Google Scholar J. Oba, J. Oba Department of Dermatology Graduate School of Medical Sciences Kyushu University 3‐1‐1 Maidashi Higashi‐ku Fukuoka 812‐8582 Japan Search for other works by this author on: Oxford Academic Google Scholar H. Esaki, H. Esaki Department of Dermatology Graduate School of Medical Sciences Kyushu University 3‐1‐1 Maidashi Higashi‐ku Fukuoka 812‐8582 Japan Search for other works by this author on: Oxford Academic Google Scholar M. Furue M. Furue Department of Dermatology Graduate School of Medical Sciences Kyushu University 3‐1‐1 Maidashi Higashi‐ku Fukuoka 812‐8582 Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 1, 1 July 2015, Pages 250–252, https://doi.org/10.1111/bjd.13557 Published: 01 July 2015
Bilateral Carotid Sinus Nerve Electrical Stimulation (Baropacer) Therapy of Refractory Hypertension.
Authors: Allan B. Schwartz
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Bilateral Carotid Sinus Nerve Electrical Stimulation (Baropacer) Therapy of Refractory Hypertension.Allan B. Schwartz, M.D., Robert Slifkin, M.D., James Greco, M.D., Gaddo Onesti, M.D., Kwan E. Kim, M.D., F.A.C.P., Joel Chinitz, M.D., Charles Swartz, M.D., F.A.C.P.Allan B. Schwartz, M.D.Search for more papers by this author, Robert Slifkin, M.D.Search for more papers by this author, James Greco, M.D.Search for more papers by this author, Gaddo Onesti, M.D.Search for more papers by this author, Kwan E. Kim, M.D., F.A.C.P.Search for more papers by this author, Joel Chinitz, M.D.Search for more papers by this author, Charles Swartz, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-875_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEight patients with moderate to severe essential hypertension were treated with implanted bilateral carotid sinus-nerve electrical stimulator (Baropacer). All patients were either refractory or intolerant to combinations of large doses of multiple, potent antihypertensive drugs. The clinical results and acute cardiac and renal hemodynamic effects of Baropacer therapy were evaluated. Hemodynamic evaluations were carried out with five patients in both the supine and 45-deg upright tilt positions. Supine, the mean blood pressure decreased an average of 42 mm Hg (27%). Cardiac output decreased 5%, heart rate decreased 15%, and peripheral vascular resistance decreased 24%. Upright, mean blood pressure decreased 38%,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Allan B. Schwartz, M.D.; Robert Slifkin, M.D.; James Greco, M.D.; Gaddo Onesti, M.D.; Kwan E. Kim, M.D., F.A.C.P.; Joel Chinitz, M.D.; Charles Swartz, M.D., F.A.C.P.Affiliations: Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 875-875KeywordsBlood pressureCardiac outputDrugsHeart rateHemodynamicsHypertensionNervesPeripheral vascular resistance ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Influence of baseline lipids on effectiveness of pravastatin in the CARE trial
Authors: Marc A Pfeffer, Frank M Sacks, Lemuel A Moyé, Cara East, Steven Goldman, David T Nash, Jacques R Rouleau, Jean Lucien Rouleau, Bruce A Sussex, Pierre Theroux, Ron J Vanden Belt, Eugene Braunwald
Journal: Journal of the American College of Cardiology (1999)
Incremental Value of Continuous Glucose Monitoring When Starting Pump Therapy in Patients With Poorly Controlled Type 1 Diabetes
Authors: Denis Raccah, Véronique Sulmont, Yves Reznik, Bruno Guerci, Eric Renard, Hélène Hanaire, Nathalie Jeandidier, Marc Nicolino
Journal: Diabetes Care (2009)

OBJECTIVE To compare the improvements in glycemic control associated with transitioning to insulin pump therapy in patients using continuous glucose monitoring versus standard blood glucose self-monitoring. RESEARCH DESIGN AND METHODS The RealTrend study was a 6-month, randomized, parallel-group, two-arm, open-label study of 132 adults and children with uncontrolled type 1 diabetes (A1C ≥8%) being treated with multiple daily injections. One group was fitted with the Medtronic MiniMed Paradigm REAL-Time system (PRT group), an insulin pump with integrated continuous subcutaneous glucose monitoring (CGM) capability, with instructions to wear CGM sensors at least 70% of the time. Conventional insulin pump therapy was initiated in the other group (continuous subcutaneous insulin infusion [CSII] group). Outcome measures included A1C and glycemic variability. RESULTS A total of 115 patients completed the study. Between baseline and trial end, A1C improved significantly in both groups (PRT group −0.81 ± 1.09%, P &amp;lt; 0.001; CSII group −0.57 ± 0.94%, P &amp;lt; 0.001), with no significant difference between groups. When the 91 patients who were fully protocol-compliant (including CGM sensor wear ≥70% of the time) were considered, A1C improvement was significantly greater in the PRT group (P = 0.004) (PRT group −0.96 ± 0.93%, P &amp;lt; 0.001; CSII group −0.55 ± 0.93%, P &amp;lt; 0.001). Hyperglycemia parameters decreased in line with improvements in A1C with no impact on hypoglycemia. CONCLUSIONS CGM-enabled insulin pump therapy improves glycemia more than conventional pump therapy during the first 6 months of pump use in patients who wear CGM sensors at least 70% of the time.
Role of the glucosamine pathway in fat-induced insulin resistance.
Authors: M Hawkins, N Barzilai, R Liu, M Hu, W Chen, L Rossetti
Journal: Journal of Clinical Investigation (1997)

To examine whether the hexosamine biosynthetic pathway might play a role in fat-induced insulin resistance, we monitored the effects of prolonged elevations in FFA availability both on skeletal muscle levels of UDP-N-acetyl-hexosamines and on peripheral glucose disposal during 7-h euglycemic-hyperinsulinemic (approximately 500 microU/ml) clamp studies. When the insulin-induced decrease in the plasma FFA levels (to approximately 0.3 mM) was prevented by infusion of a lipid emulsion in 15 conscious rats (plasma FFA approximately 1.4 mM), glucose uptake (5-7 h = 32.5+/-1.7 vs 0-2 h = 45.2+/-2.8 mg/kg per min; P < 0.01) and glycogen synthesis (P < 0.01) were markedly decreased. During lipid infusion, muscle UDP-N-acetyl-glucosamine (UDP-GlcNAc) increased by twofold (to 53.4+/-1.1 at 3 h and to 55.5+/-1.1 nmol/gram at 7 h vs 20.4+/-1.7 at 0 h, P < 0.01) while glucose-6-phosphate (Glc-6-P) levels were increased at 3 h (475+/-49 nmol/gram) and decreased at 7 h (133+/-7 vs 337+/-28 nmol/gram at 0 h, P < 0.01). To discern whether such an increase in the skeletal muscle UDP-GlcNAc concentration could account for the development of insulin resistance, we generated similar increases in muscle UDP-GlcNAc using three alternate experimental approaches. Euglycemic clamps were performed after prolonged hyperglycemia (18 mM, n = 10), or increased availability of either glucosamine (3 micromol/kg per min; n = 10) or uridine (30 micromol/kg per min; n = 4). These conditions all resulted in very similar increases in the skeletal muscle UDP-GlcNAc (to approximately 55 nmol/gram) and markedly impaired glucose uptake and glycogen synthesis. Thus, fat-induced insulin resistance is associated with: (a) decreased skeletal muscle Glc-6-P levels indicating defective transport/phosphorylation of glucose; (b) marked accumulation of the endproducts of the hexosamine biosynthetic pathway preceding the onset of insulin resistance. Most important, the same degree of insulin resistance can be reproduced in the absence of increased FFA availability by a similar increase in skeletal muscle UDP-N-acetyl-hexosamines. In conclusion, our results support the hypothesis that increased FFA availability induces skeletal muscle insulin resistance by increasing the flux of fructose-6-phosphate into the hexosamine pathway.
Exhaled nitric oxide in sarcoidosis
Authors: M L Wilsher
Journal: Thorax (2005)

<b>Background:</b> Increased production of nitric oxide (NO) by the lower respiratory tract is viewed as a marker of airway inflammation in asthma and bronchiectasis. NO is a potentially important immune modulator, inhibiting the release of several key pro-inflammatory cytokines. As sarcoidosis is characterised by granulomatous airway inflammation, we hypothesised that exhaled NO levels might be raised in sarcoidosis and correlate with the morphological extent and functional severity of disease. <b>Methods:</b> Fifty two patients with sarcoidosis (29 men) of mean age 42 years underwent thin section computed tomography (CT), pulmonary function tests, and measurement of exhaled NO. <b>Results:</b> Exhaled NO levels (median 6.8 ppb, range 2.4–21.8) did not differ significantly from values in 44 control subjects, and were not related to the extent of individual CT abnormalities or the level of pulmonary function impairment. <b>Conclusion:</b> Exhaled NO levels are not increased in pulmonary sarcoidosis.
Human bone marrow lymphocytes. I. Distribution of lymphocyte subpopulations in the bone marrow of normal individuals.
Authors: A S Fauci
Journal: Journal of Clinical Investigation (1975)

This study was undertaken to determine the proportions and in vitro immune capacities of lymphocyte populations in the bone marrows of normal humans. Relatively pure mononuclear cell suspensions were obtained from bone marrow aspirates by linear sucrose gradient centrifugations. Simultaneous peripheral blood and bone marrow specimens from each individual were assayed for lymphocyte surface markers and mitogen responsiveness. Maximal possible contamination of bone marrow aspirates by peripheral blood was determined by performing aspirates on individuals who had received 51chromium-labeled autologous erythrocytes. Rhymus-derived (T) lymphocytes, as determined by the sheep red blood cell (E) rosette assay, comprised 8.6-(plus or minus 1.6)% of the total bone marrow lymphocyte pool. Bone marrow-derived (B) lymphocytes, as determined by the presence of a complement receptor, made up 15.4-(plus or minus 1.9)% of the lymphocyte pool whereas 74.6 (plus or minus 2.4)% of mononuclear cells lacked easily detectable surface markers. These findings could not be explained by contamination with peripheral blood lymphocytes since contamination was corrected for in the calculations. Lymphocyte-enriched suspensions of bone marrow cells responded to stimulation with phytohemagglutinin, concanalin A, and particularly pokeweed mitogen. In vitro incubations of bone marrow and peripheral blood lymphocytes with tritiated thymidine followed by determinations of E and erythrocyte antibody complement (EAC) rosettes were performed. Simultaneous rosetteradioautographs demonstrated that the proliferative potential of bone marrow B lymphocytes was greater than peripheral blood B lymphocytes (P less than 0.01). On the other hand, the proliferative potential of bone marrow T lymphocytes was the same as that of peripheral blood T lymphocytes. These findings demonstrate that in addition to containing B lymphocytes the normal bone marrow contains a small fraction of T lymphocytes similar to the mature T lymphocyte pool found in the peripheral blood. These T cells most probably enter the bone marrow parenchyma as part of the normal recirculating lymphocyte pool.
1019 ANALYSIS OF HISTOLOGICAL AND IMMUNOHISTOCHEMICAL PATTERN OF HEPATOCELLULAR CARCINOMA EXPRESSING CYTOKERATIN 7 BY COMPUTERIZED MORPHOMETRY
Authors: M. Vertemati, E. Minóla, C. Moscheni, D. Petrella, M. Cossa, M. Goffredi, L. Vizzotto
Journal: Journal of Hepatology (2011)
Electrophysiological and clinical observations in patients with alternating bundle branch block.
Authors: D Wu, P Denes, R C Dhingra, F Amat-Y-Leon, C R Wyndham, R Chuquimia, K M Rosen
Journal: Circulation (1976)

Electrophysiological studies (His bundle recordings and atrial stimulation) were performed in nine patients who manifested periods of both right and left bundle branch block (RBBB and LBBB). In seven of the patients, alternating bundle branch block appeared to reflect intermittent or chronic bundle branch block superimposed on incomplete (but electrocardiographically complete) block of the contralateral bundle branch. In three of these seven, shift from one bundle branch block pattern to the other was associated with reproducible change in H-V (mean change 30 msec), and could be induced by alteration of cardiac rate with carotid massage, coupled atrial stimulation, and rapid atrial pacing. In one of the seven, RBBB with a P-R of 0.20 seconds preceded chronic LBBB with a P-R of 0.24 seconds, implying that RBBB had been incomplete. In three of the seven, although a definite mechanism of alternation could not be demonstrated, transient contralateral bundle branch block occurred superimposed on chronic ipsilateral bundle branch block, implying that the ipsilateral block was incomplete. Two patients manifested periods of narrow QRS, LBBB, RBBB, and paroxysmal A-V block. Based upon pathological data (one case), this pattern appeared to reflect a lesion involving the distal His bundle and proximal bundle branches. In the total group of patients, clinical course was primarily determined by the severity of heart disease and not by occurrence of A-V block. The conduction defect in the majority of patients was surprisingly benign.
Successful treatment of a patient with chronic Lyme arthritis with extracorporeal photochemotherapy
Authors: Jean P. Randazzo, Francis X. DiSpaltro, Carolyn Cottrill, Albert S. Klainer, Allen C. Steere, Emil Bisaccia
Journal: Journal of the American Academy of Dermatology (1994)

We report the use of photopheresis in a patient with chronic Lyme arthritis with apparent resolution of the signs and symptoms.Further controlled trials will be required to determine whether there is a therapeutic role for photopheresis in this disease.
ABSOLUTE INCREASE OF MEASUREMENT FROM THE ANTERIOR SUPERIOR SPINE TO THE MALLEOLUS AS A SIGN OF HYSTERIC HIP DISEASE.
Authors: JAMES JACKSON PUTNAM
Journal: JAMA (1901)

The differential diagnosis between tubercular and hysterical hip disease is sometimes easy but, on the other hand, sometimes exceedingly difficult, especially if the test examination under ether can not be resorted to; while the importance of a correct decision is always great, both from the medicolegal and the clinical standpoints. Gilles de la Tourette, in an excellent review of the subject, gives a number of diagnostic signs—left side involved oftener than the right; pain, spontaneous or induced by pressure and motion, not only about the joints but at various points along the affected limb; relatively great development of cutaneous hyperesthesia; absence of nocturnal paroxysms; the presence of hysterical edema about the affected joint and limb; involvement of the knee muscles in the rigidity; coldness of the affected parts; finally, the presence of other well-marked hysterical signs—most of which are approved by my own experience. To this list the sign indicated
Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide
Authors: Eric I. Zimmerman, Shuiying Hu, Justin L. Roberts, Alice A. Gibson, Shelley J. Orwick, Lie Li, Alex Sparreboom, Sharyn D. Baker
Journal: Clinical Cancer Research (2013)

Abstract Purpose: Many tyrosine kinase inhibitors (TKI) undergo extensive hepatic metabolism, but mechanisms of their hepatocellular uptake remain poorly understood. We hypothesized that liver uptake of TKIs is mediated by the solute carriers OATP1B1 and OATP1B3. Experimental Design: Transport of crizotinib, dasatinib, gefitinib, imatinib, nilotinib, pazopanib, sorafenib, sunitinib, vandetanib, and vemurafenib was studied in vitro using artificial membranes (PAMPA) and HEK293 cell lines stably transfected with OATP1B1, OATP1B3, or the ortholog mouse transporter, Oatp1b2. Pharmacokinetic studies were conducted with Oatp1b2-knockout mice and humanized OATP1B1- or OATP1B3-transgenic mice. Results: All 10 TKIs were identified as substrates of OATP1B1, OATP1B3, or both. Transport of sorafenib was investigated further, as its diffusion was particularly low in the PAMPA assay (&amp;lt;4%) than other TKIs that were transported by both OATP1B1 and OATP1B3. Whereas Oatp1b2 deficiency in vivo had minimal influence on parent and active metabolite N-oxide drug exposure, plasma levels of the glucuronic acid metabolite of sorafenib (sorafenib-glucuronide) were increased more than 8-fold in Oatp1b2-knockout mice. This finding was unrelated to possible changes in intrinsic metabolic capacity for sorafenib-glucuronide formation in hepatic or intestinal microsomes ex vivo. Ensuing experiments revealed that sorafenib-glucuronide was itself a transported substrate of Oatp1b2 (17.5-fold vs. control), OATP1B1 (10.6-fold), and OATP1B3 (6.4-fold), and introduction of the human transporters in Oatp1b2-knockout mice provided partial restoration of function. Conclusions: These findings signify a unique role for OATP1B1 and OATP1B3 in the elimination of sorafenib-glucuronide and suggest a role for these transporters in the in vivo handling of glucuronic acid conjugates of drugs. Clin Cancer Res; 19(6); 1458–66. ©2013 AACR.
Implicit metacognition, explicit uncertainty, and the monitoring/control distinction in animal metacognition
Authors: Lisa K. Son, Bennett L. Schwartz, Nate Kornell
Journal: Behavioral and Brain Sciences (2003)

Smith et al. demonstrate the viability of animal metacognition research. We commend their effort and suggest three avenues of research. The first concerns whether animals are explicitly aware of their metacognitive processes. The second asks whether animals have metaknowledge of their own uncertain responses. The third issue concerns the monitoring/control distinction. We suggest some ways in which these issues elucidate metacognitive processes in nonhuman animals.