Introduction to Supplement on Iron Overload, Public Health, and Genetics
Authors: Adele L. Franks
Journal: Annals of Internal Medicine (1998)

Iron Overload, Public Health, and Genetics1 December 1998Introduction to Supplement on Iron Overload, Public Health, and GeneticsAdele L. Franks, MD and James S. Marks, MD, MPHAdele L. Franks, MDFrom Centers for Disease Control and Prevention; Atlanta, GA 30341.Dr. Marks: Office of the Director, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop K-40, 4770 Buford Highway, Atlanta, GA 30341.Search for more papers by this author and James S. Marks, MD, MPHFrom Centers for Disease Control and Prevention; Atlanta, GA 30341.Dr. Marks: Office of the Director, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop K-40, 4770 Buford Highway, Atlanta, GA 30341.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-11_Part_2-199812011-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The past few years have witnessed a growing awareness that iron overload diseases are not as rare as was previously believed. One particular form of primary iron overload disease-hereditary hemochromatosis-has received increasing attention because it seems to be more common than many other serious genetic disorders [1], it can be detected before clinical symptoms develop [1, 2], and its complications can be safely prevented through the early use of therapeutic phlebotomy [3]. For these reasons, it has been suggested that phenotypic screening for hereditary hemochromatosis should be a routine part of health care for adults [4, 5]. Efforts to estimate ...References 1. Bradley LA, Haddow JE, Palomaki GE. Population screening for haemochromatosis: a unifying analysis of published intervention trials. J Med Screen. 1996;3:178-84. CrossrefMedlineGoogle Scholar 2. Bradley LA, Haddow JE, Palomaki GE. Population screening for haemochromatosis: expectations based on a study of relatives of symptomatic probands. J Med Screen. 1996;3:171-7. CrossrefMedlineGoogle Scholar 3. Niederau C, Fischer R, Purschel A, Stremmel W, Haussinger D, Strohmeyer G. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology. 1996;110:1107-19. CrossrefMedlineGoogle Scholar 4. Witte DL, Crosby WH, Edwards CQ, Fairbanks VF, Mitros FA. Practice Guideline Development Task Force of the College of American Pathologists. Hereditary hemochromatosis. Clin Chim Acta. 1996;245:139-200. CrossrefMedlineGoogle Scholar 5. Haddow JE, Ledue TB. Preventing manifestations of hereditary haemochromatosis through population based screening. J Med Screen. 1994;1:16-21. CrossrefMedlineGoogle Scholar 6. Baer DM, Simons JL, Staples RL, Rumore GJ, Morton CJ. Hemochromatosis screening in asymptomatic ambulatory men 30 years of age and older. Am J Med. 1995;98:464-8. CrossrefMedlineGoogle Scholar 7. Phatak PD, Guzman G, Woll JE, Robeson A, Phelps CE. Cost-effectiveness of screening for hereditary hemochromatosis. Arch Intern Med. 1994;154:769-76. CrossrefMedlineGoogle Scholar 8. Simon M, Bourel M, Genetet B, Fauchet R. Idiopathic hemochromatosis. Demonstration of recessive transmission and early detection by family HLA typing. N Engl J Med. 1977;297:1017-21. CrossrefMedlineGoogle Scholar 9. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al . A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996;13:399-408. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Centers for Disease Control and Prevention; Atlanta, GA 30341.Dr. Marks: Office of the Director, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop K-40, 4770 Buford Highway, Atlanta, GA 30341.Note: This article is one of a series of articles comprising an Annals of Internal Medicine supplement entitled “Iron Overload, Public Health, and Genetics.” To view a complete list of the articles included in this supplement, please view its Table of Contents.Corresponding Author: Adele L. Franks MD, Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop K-24, 4770 Buford Highway, Atlanta, GA 30341; e-mail, [email protected]gov.Current Author Addresses: Dr. Franks: Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop K-24, 4770 Buford Highway, Atlanta, GA 30341. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySerum Ferritin Levels in Poorly‐ and Well‐Controlled Diabetes MellitusIron Overload, Public Health, and Genetics: Evaluating the Evidence for Hemochromatosis ScreeningMary E. Cogswell, DrPH, Sharon M. McDonnell, MD, MPH, Muin J. Khoury, MD, PhD, Adele L. Franks, MD, Wylie Burke, MD, PhD, and Gary Brittenham, MD 1 December 1998Volume 129, Issue 11_Part_2Page: 923-924KeywordsGenetic diseasesGenetic predispositionGenetic testingHealth careHemochromatosisLaboratory testsPrevention, policy, and public healthResearch laboratoriesScientistsSigns and symptoms Issue Published: 1 December 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...