tbuckley/cabot-search huggingface dataset:
Questionnaire to Distinguish between Stress and Urge Urinary Incontinence
Authors: Shriprakash Kalantri
Journal: Annals of Internal Medicine (2006)

Letters19 December 2006Questionnaire to Distinguish between Stress and Urge Urinary IncontinenceShriprakash Kalantri, MD, MPHShriprakash Kalantri, MD, MPHFrom Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-12-200612190-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: Brown and colleagues (1) evaluate the diagnostic accuracy of the 3 Incontinence Questions (3IQ) for discriminating between types of urinary incontinence and suggest that the questionnaire may be used to classify and treat women with urinary incontinence in the primary care setting. The data from the study, however, indicate that the authors' confidence in the 3IQ is misplaced. We can interpret the results of the study by using likelihood ratios to compute posttest probabilities (predictive values). With the extended evaluation as the reference standard, the prevalence (pretest probability) of urge incontinence in the study was 39% (119 ...References1. Brown JS, Bradley CS, Subak LL, Richter HE, Kraus SR, Brubaker L, et al. The sensitivity and specificity of a simple test to distinguish between urge and stress urinary incontinence. Ann Intern Med. 2006;144:715-23. [PMID: 16702587] LinkGoogle Scholar2. Jaeschke R, Guyatt G, Lijmer J. Diagnostic tests.. In: Guyatt G, Rennie D, eds. Users' Guide to the Medical Literature: A Manual for Evidence-Based Clinical Practice. Chicago: American Med Assoc Pr; 2002:121-40. Google Scholar Author, Article, and Disclosure InformationAuthors: Shriprakash Kalantri, MD, MPHAffiliations: From Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Sensitivity and Specificity of a Simple Test To Distinguish between Urge and Stress Urinary Incontinence Jeanette S. Brown , Catherine S. Bradley , Leslee L. Subak , Holly E. Richter , Stephen R. Kraus , Linda Brubaker , Feng Lin , Eric Vittinghoff , and Deborah Grady , for the Diagnostic Aspects of Incontinence Study (DAISy) Research GroupQuestionnaire to Distinguish between Stress and Urge Urinary Incontinence Karel G.M. Moons Questionnaire to Distinguish between Stress and Urge Urinary Incontinence Steven A. Rich Questionnaire to Distinguish between Stress and Urge Urinary Incontinence Jeanette S. Brown , Eric Vittinghoff , and Leslee L. Subak Metrics 19 December 2006Volume 145, Issue 12Page: 934KeywordsConflicts of interestIncontinenceQuestionnaires ePublished: 19 December 2006 Issue Published: 19 December 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
140 FASTING PROTECTS AGAINST HEPATIC ISCHEMIA-REPERFUSION INJURY VIA UPREGULATION OF HO-1 AND ANTIOXIDANT DEFENCE
Authors: M. Verweij, T.M. van Ginhoven, J.R. Mitchell, S. van den Engel, F. Bonthuis, E. Torabi, J.N.M. IJzermans, J.H.J. Hoeijmakers, R.W.F. de Bruin
Journal: Journal of Hepatology (2010)
THE DANGER OF SYMPATHETIC OPHTHALMIA FROM THE USE OF THE CAUTERY IN TREATING IRIS-PROLAPSEOTHER METHODS OF TREATMENT
Authors: H. GIFFORD
Journal: JAMA (1910)

In 1897 Trousseau<sup>1</sup>reported three cases of sympathetic ophthalmia (two of his own and one of Kalt's) following the use of the galvanocautery in treating prolapse of the iris; and in the same year<sup>2</sup>I felt impelled by my own experience to second the warning given by Trousseau. Since then I have happened to notice the histories of seven cases of sympathetic ophthalmia in which the authors mentioned incidentally that a wound or an iris prolapse had been cauterized a suitable length of time before the outbreak of the disease in the second eye. These cases were reported by the following authors: Alexander,<sup>3</sup>Darier,<sup>4</sup>Alberti,<sup>5</sup>Dimmer,<sup>6</sup>and Fuchs,<sup>7</sup>who each report a case occurring after cauterization of an iris prolapse or a cystoid scar; and Cohn<sup>8</sup>mentions two cases from the clinic of Silex in which a wound was cauterized before the
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
Authors: Lydie Trautmann, Loury Janbazian, Nicolas Chomont, Elias A. Said, Sylvain Gimmig, Benoit Bessette, Mohamed Rachid Boulassel, Eric Delwart, Homero Sepulveda, Robert S. Balderas, Jean Pierre Routy, Elias K. Haddad, Rafick Pierre Sekaly
Journal: Nature Medicine (2006)
Stepped Care for Back Pain: Activating Approaches for Primary Care
Authors: Michael Von Korff
Journal: Annals of Internal Medicine (2001)

Interventions that encourage return to normal function and reduce fear of physical activity have been shown to improve outcomes for patients with back pain, but routine medical care for back pain often does not provide such interventions. This paper proposes a stepped-care approach that addresses the functional outcomes of back pain. Step 1, which is relevant to most patients, addresses the common fears of patients with back pain and encourages patients to resume normal activities. Step 2, which targets the substantial minority of patients who require more than simple advice to resume activities, provides brief, structured interventions that support physical exercise and return to normal activities. Step 3 targets patients who require more intensive interventions, including treatment of psychological illness when present, before they can return to normal activities in work and family life. Patient needs relevant to these three levels of care are delineated. This stepped-care approach provides a framework for sequencing progressively more intensive interventions and coordinating the efforts of primary care physicians, allied health professionals, behavioral health clinicians, and patients to improve functional outcomes in patients with back pain.
Polo-like Kinase 1 (Plk1) as a Novel Drug Target in Chronic Myeloid Leukemia: Overriding Imatinib Resistance with the Plk1 Inhibitor BI 2536
Authors: Karoline V. Gleixner, Veronika Ferenc, Barbara Peter, Alexander Gruze, Renata A. Meyer, Emir Hadzijusufovic, Sabine Cerny-Reiterer, Matthias Mayerhofer, Winfried F. Pickl, Christian Sillaber, Peter Valent
Journal: Cancer Research (2010)

In most patients with chronic myeloid leukemia (CML), the disease can be kept under control using the BCR/ABL kinase inhibitor imatinib. Nevertheless, resistance or intolerance to imatinib and other BCR/ABL inhibitors may occur during therapy. Therefore, CML research is focusing on novel targets and targeted drugs. Polo-like kinase 1 (Plk1) is a serine/threonine kinase that plays an essential role in mitosis. In this study, we examined the expression of Plk1 in CML cells and its potential role as a therapeutic target. Plk1 was found to be expressed in phosphorylated form in the CML cell line K562 as well as in primary CML cells in all patients tested. Inhibition of BCR/ABL by imatinib or nilotinib (AMN107) led to decreased expression of the Plk1 protein in CML cells, suggesting that BCR/ABL promotes Plk1 generation. Silencing of Plk1 in CML cells by a small interfering RNA approach was followed by cell cycle arrest and apoptosis. Furthermore, the Plk1-targeting drug BI 2536 was found to inhibit proliferation of imatinib-sensitive and imatinib-resistant CML cells, including leukemic cells, carrying the T315 mutation of BCR/ABL with reasonable IC(50) values (1-50 nmol/L). The growth-inhibitory effects of BI 2536 on CML cells were found to be associated with cell cycle arrest and apoptosis. Moreover, BI 2536 was found to synergize with imatinib and nilotinib in producing growth inhibition in CML cells. In conclusion, Plk1 is expressed in CML cells and may represent a novel, interesting target in imatinib-sensitive and imatinib-resistant CML.
Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes
Authors: W. Spinelli, I. F Moubarak, R. W Parsons, T. J Colatsky
Journal: Cardiovascular Research (1993)

The objectives were (a) to evaluate the effects of WAY-123,398, a new class III antiarrhythmic agent, on the action potential of canine Purkinje fibres in comparison with dofetilide, E-4031, and dl-sotalol, and (b) to characterise the mechanism of the class III action by studying its effects on several ionic currents in isolated cat myocytes.Transmembrane potentials in Purkinje fibres were studied with standard microelectrodes filled with 3M KCl. Myocytes were isolated by enzymatic disaggregation with collagenase and current recordings were obtained by voltage clamp with either the nystatin perforated patch technique or the usual whole cell configuration.WAY-123,398 prolonged action potential duration (APD) in Purkinje fibres and in cat ventricular myocytes without altering other variables of the action potential; in Purkinje fibres the concentration producing a 20% prolongation of APD-60 mV at a basic cycle length of 1000 ms was 0.2 microM. After depolarising voltage steps, the delayed rectifier (IK) peak tail currents in cat myocytes were blocked with IC50 = 0.1 microM. The block was unaffected by varying the duration (200 to 500 ms) or the frequency (0.4 to 2.5 Hz) of the depolarising steps. A much higher concentration of WAY-123,398 (10 microM) did not have effects on the L type Ca current (ICa-L), and on the inward rectifier (IK1) and transient outward (I(to)) K currents.The results indicate that WAY-123,398 is an effective and specific class III agent devoid of class I activity, and suggest that WAY-123,398 prolongs cardiac repolarisation by specifically blocking the delayed rectifier current (IK). The block was unchanged over a range of frequencies and duration of depolarisation, showing no evidence of "reverse use dependence" of block.
Smoking and Disease
Authors: PAUL HAMOSH
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 October 1975Smoking and DiseasePAUL HAMOSH, M.D., ANGELO M. T. DA SILVA, M.D.PAUL HAMOSH, M.D.Search for more papers by this author, ANGELO M. T. DA SILVA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-4-572_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their paper "Smoking as a Cause of Erythrocytosis" (Ann Intern Med82:512-515), Sagone and Balcerzak report on five patients of whom "three had no pulmonary disease." They base this conclusion on pulmonary function studies consisting of the measurement of vital capacity, maximum voluntary ventilation, and forced expiratory volume at one second. We wish to draw their attention to the fact that these tests are inadequate to arrive at such a conclusion. Macklem, Thurlbeck, and Fraser (1) recently described in this journal a new entity, small airways disease, in which pulmonary function tests may be normal in...References1. MACKLEM P, THURLBECK W, and FRASER R: Chronic obstructive disease of small airways. Ann Intern Med 74:167-177, 1971 LinkGoogle Scholar2. HAMOSH P and DA SILVA A: Supine hypoxemia and erythrocytosis due to airway closure at low lung volumes. Am J Med 55:80-85, 1973 CrossrefMedlineGoogle Scholar3. CRAIG D, WAHBA W, and DON H: "Closing volume" and its relationship to gas exchange in seated and supine positions. J Appl Physiol 31:717-721, 1971 CrossrefMedlineGoogle Scholar4. ANTHONISEN N, DANSON J, and ROBERTSON P: Airway closure as a function of age. Resptr Physiol 8:58-65, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL HAMOSH, M.D.; ANGELO M. T. DA SILVA, M.D.Affiliations: Department of Physiology and Biophysics Georgetown University School of Medicine Washington, D.C. 20007 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1975Volume 83, Issue 4Page: 572-574KeywordsForced expiratory volumePolycythemiaPulmonary diseasesPulmonary function ePublished: 1 December 2008 Issue Published: 1 October 1975 PDF downloadLoading ...
TCT-836 Prediction of paravalvular leaks after transcatheter aortic valve implantation by valvular or annular calcification?
Authors: Gudrun Feuchtner, Fabian Plank, Thomas Bartel, Nikos Bonaros, Silvana Müller, Jonathon Leipsic, Guy Friedrich
Journal: Journal of the American College of Cardiology (2012)
Survey highlights differences in cardiac care in Europe
Authors: R. Watson
Journal: BMJ (2008)

The first comparative analysis of cardiac care in 29 European countries shows that the best treatment, ranging from prevention to rehabilitation, is in Luxembourg, France, Norway, and Switzerland.

The findings are contained in the Euro Consumer Heart Index 2008 , produced by the Health Consumer Powerhouse, a provider of healthcare information for the public, based in Stockholm and Brussels.

The method is based on the techniques that the organisation has developed for the more general Euro Health Consumer Index it has produced since 2005.

On this occasion, the performance of the …
American Academy of Allergy, Asthma &amp; Immunology/American College of Allergy, Asthma &amp; Immunology Omalizumab-Associated Anaphylaxis Joint Task Force follow-up report
Authors: Linda Cox, Phillip Lieberman, Dana Wallace, F. Estelle R. Simons, Ira Finegold, Thomas Platts-Mills, Lawrence Schwartz
Journal: Journal of Allergy and Clinical Immunology (2011)
Multiple acquisitions via horizontal transfer of a group I intron in the mitochondrial cox1 gene during evolution of the Araceae family
Authors: Y. Cho, J. D. Palmer
Journal: Molecular Biology and Evolution (1999)

A group I intron has recently been shown to have invaded mitochondrial cox1 genes by horizontal transfer many times during the broad course of angiosperm evolution. To investigate the frequency of acquisition of this intron within a more closely related group of plants, we determined its distribution and inferred its evolutionary history among 14 genera of the monocot family Araceae. Southern blot hybridizations showed that 6 of the 14 genera contain this intron in their cox1 genes. Nucleotide sequencing showed that these six introns are highly similar in sequence (97.7%-99.4% identity) and identical in length (966 nt). Phylogenetic evidence from parsimony reconstructions of intron distribution and phylogenetic analyses of intron sequences is consistent with a largely vertical history of intron transmission in the family; the simplest scenarios posit but one intron gain and two losses. Despite this, however, striking differences in lengths of exonic co-conversion tracts, coupled with the absence of co-conversion in intron-lacking taxa, indicate that the six intron-containing Araceae probably acquired their introns by at least three and quite possibly five separate horizontal transfers. The highly similar nature of these independently acquired introns implies a closely related set of donor organisms.
Heatwaves and hospital staff: Highest level was not reached
Authors: M. W Gill
Journal: BMJ (2006)

EDITOR—The editorial by Kovats raises some important issues about public health action in response to severe weather.1 The article states that in July the United Kingdom experienced a more severe heat-wave than in 2003. Although the “average” temperature for July broke all records for any month, the temperatures in 2003 were higher for longer. This distinction is recognised in the heatwave plan for England, where alerts are based on duration as well as on daytime and night-time temperature.

It is obviously very early to be drawing firm conclusions about the impact of the plan, just over two weeks after the last “level …
Decreased sensitivity of old and progeric human fibroblasts to a preparation of factors with insulinlike activity.
Authors: C B Harley, S Goldstein, B I Posner, H Guyda
Journal: Journal of Clinical Investigation (1981)

To determine whether old cells have a reduced response to a preparation of factors from human plasma with insulinlike activity (ILA), we analyzed the response to ILA of early and late passage human fibroblasts from young, old, and progeric donors in the acute stimulation of [3H]2-deoxy-D-glucose (2dG) uptake and the delayed stimulation of [3H]thymidine (TdR) incorporation into DNA. The ILA concentration required to produce equivalent, relative stimulation of TdR incorporation was increased two- to three-fold in late passage cells and cells from old and progeric donors (P less than 0.01). 50 and 95% of maximal stimulation (ILA50, ILA95) was achieved by 0.26 +/- 0.07 and 1.38 +/- 0.13 ng insulin equivalents/ml (mean +/- SD) respectively, in cells from young adults at early passage. Corresponding values were 0.54 +/- 0.05 and 2.90 +/- 0.25 in cells from old donors; greater than 0.9 +/- 0.1 and greater than 3.1 +/- 0.1 in cells from a 9-yr-old progeric donor; and 0.4 +/- 0.05 and 1.1 +/- 0.04 in cells from normal children (9-13 yr). For two cell strains from young adults, ILA50 and ILA95 were 0.30 +/- 0.02 and 1.0 +/- 0.3 ng eq/ml at 30% of their in vitro lifespan completed (%LC) and these values increased at rates of 0.005 ng eq/ml per %LC and 0.04 ng eq/ml per %LC, respectively. The mean stimulation of 2dG uptake ratio (ILA/control) decreased from early to late passage from 2.1 +/- 0.6 to 1.3 +/- 0.1 in young adult donors (P less than 0.05), but there were no significant differences between young and old donors at either early or late passage. The mean stimulation ratio in progeric cells (1.2 +/- 0.2) did not change with in vitro passage, but was significantly lower than that of age-matched normal cells (2.1 +/- 0.8, P less than 0.001). In progeria cells, the reduced stimulation of 2dG uptake upon addition of ILA was due to an increased basal rate of uptake (0.19 +/- 0.01 pmol [3H]2dG/min per mg protein vs. 0.13 +/- 0.01 in age-matched normal cells), and not to a decline in the maximal rate of uptake (0.26 +/- 0.01 vs. 0.27 +/- 0.02, respectively). Similar results were found for in vitro aging in cells from an old donor.
The Myth of Sisyphus
Authors: Joseph Herman
Journal: Annals of Internal Medicine (1993)

Ad Libitum15 September 1993The Myth of SisyphusJoseph Herman, MDJoseph Herman, MDBen-Gurion University of the Negev, Beer-Sheva, Israel.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The approach of retirement makes you sentimental. All kinds of things formerly ingrained in the workaholic routine of medicine suddenly take place for the last time. You begin to welcome and hang on to the few patients who grated on your nerves with perpetual needfulness, seeming ingratitude, and unending attempts to manipulate and load you down with feelings of guilt. They, too, come into the consulting room with a So you're really going to leave us, making them almost likable, as though they had suddenly awakened to the fact that even a person who got paid for being there has ... Author, Article, and Disclosure InformationAffiliations: Ben-Gurion University of the Negev, Beer-Sheva, Israel. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1993Volume 119, Issue 6Page: 534KeywordsEmotionsHeartNervesReasoning ePublished: 15 August 2000 Issue Published: 15 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clavicular Metastasis of Insular Carcinoma of the Thyroid Showing Increased Uptake in the Presence of a Functioning Thyroid Gland
Authors: SHASHANKA M. BOSE, NANNAPANENI RAVINDRA, GOVINDRAJ GIRDHAR, ASHISH BHATTACHARYA
Journal: Clinical Nuclear Medicine (1998)

A 40-year-old woman had a swelling over the medial end of the right clavicle and a nodule in the left lobe of the thyroid. There was greatly increased activity in the clavicular swelling. Cytologic analysis of a fine-needle aspiration from the thyroid and clavicle showed follicular carcinoma. Total thyroidectomy and segmental excision of the right clavicle was done. Histopathologic analysis revealed a poorly differentiated carcinoma with insular features. This supports the concept that insular carcinoma is a functional follicular carcinoma with good I-131 uptake.
Characterization of<i>Lactobacillus gasseri</i>isolates from a breast-fed infant
Authors: Luciana Rodrigues da Cunha, Célia L.L. Fortes Ferreira, Evelyn Durmaz, Yong Jun Goh, Rosemary Sanozky-Dawes, Todd Klaenhammer
Journal: Gut Microbes (2012)

The potential health benefits of probiotic bacteria have led to the isolation of new microbial strains for incorporation into food products. However, newly isolated candidate probiotic organisms do not automatically share the "generally recognized as safe" (GRAS) status of traditional lactic acid bacteria (LAB). Before their introduction into food products, the safety of new isolates has to be evaluated. The objective of this study was to characterize LAB isolates from the stool of a newborn infant, and evaluate their safety and probiotic potential, in vitro. Thirty colonies were identified as Lactobacillus gasseri through sequencing of 16S rDNA. Pulsed Field Gel Electrophoresis using restriction enzymes SmaI and Apa I revealed that 29 of the L. gasseri were nearly identical, however one isolate exhibited a distinctive DNA fingerprint. All 30 L. gasseri were evaluated for resistance to antibiotics, bile tolerance, hemolytic activity and antagonism toward selected pathogens. All 30 strains harbored three plasmids, with one strain that showed strong tolerance to 0.5% of bile and harbored a unique fourth plasmid encoding a putative multidrug resistance transporter protein (LmrB). No hemolytic activity or antagonism, beyond acid inhibition was observed. Three selected strains UFVCC1083, 1091 and 1112 showed strong resistance to simulated small intestinal and gastric juices and adhered in vitro to mucin and two intestinal epithelial cell lines, Caco-2 and HT-29. This study identified and characterized recently isolated L. gasseri strains from faeces of a breast fed infant as potential probiotic candidates for use in the human milk banks in Brazil.