Ferrokinetics in Hyperthyroidism
Authors: ROBERT M. DONATI
Journal: Annals of Internal Medicine (1965)

Article1 December 1965Ferrokinetics in HyperthyroidismROBERT M. DONATI, M.D., MARY ANNE WARNECKE, B.S., NEIL I. GALLAGHER, M.D.ROBERT M. DONATI, M.D.Search for more papers by this author, MARY ANNE WARNECKE, B.S.Search for more papers by this author, NEIL I. GALLAGHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-945 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlteration of thyroid function influences the synthesis and life span of the red blood cell. Anemia occurs in hypothyroid patients (1, 2) and in animals after thyroid ablation when there has been a concurrent decrease in metabolic rate (3, 4). Reversal of this decreased erythropoiesis by various metabolic stimulants (5) supports the concept that the anemia is a physiological adaptation to the decrease in total tissue oxygen requirement. Conversely, thyroid hormones augment erythropoiesis in euthyroid rodents and dogs (6-8). In addition, significant increases in the red blood cell mass of thyrotoxic patients have been noted by Muldowny, Crooks, and Wayne...References1. LARSSON SO: Anemia and iron metabolism in hypothyroidism. Acta Med. Scand. 157: 349, 1957. CrossrefMedlineGoogle Scholar2. TUDHOPEWILSON GRGM: Anaemia in hypothyroidism. Incidence, pathogenesis, and response to treatment. Quart. J. Med. 29: 513, 1960. MedlineGoogle Scholar3. CLINEBERLIN MJNI: Erythropoiesis and red cell survival in the hypothyroid dog. Amer. J. Physiol. 204: 415, 1963. CrossrefMedlineGoogle Scholar4. SHARPEBISGARD JCJD: The relation of the thyroid gland to hematopoiesis. J. Lab. Clin. Med. 21: 347, 1936. Google Scholar5. DAUGHADAYWILLIAMSDALAND WHRHGA: The effect of endocrinopathies on the blood. Blood 3: 1342, 1948. CrossrefMedlineGoogle Scholar6. 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DONATIWARNECKEGALLAGHER RMMANI: The effect of absolute caloric deprivation on thyroid hormone synthesis and release in the rat. Metabolism 12: 833, 1963. MedlineGoogle Scholar14. GALLAGHERHAGANMCCARTHYLANGE NIDQJMRD: Response of starved rats and polycythemic rats to graded doses of erythropoietin. Proc. Soc. Exp. Biol. Med. 106: 127, 1961. CrossrefMedlineGoogle Scholar15. BESTDUNCAN MMCH: Metabolic activity of the d-isomers of thyroxine and tri-iodothyronine. New Eng. J. Med. 267: 475, 1962. CrossrefMedlineGoogle Scholar16. RODMANJENSEN GPWN: A study of red blood cell survival in hypo- and hyperthyroidism. Clin. Res. Proc. 5: 8, 1957. Google Scholar17. MCCLELLANDONEGANTHORUPLEAVALL JECOABS: Survival time of the erythrocyte in myxedema and hyperthyroidism. J. Lab. Clin. Med. 51: 91, 1958. MedlineGoogle Scholar18. MEINEKECRAFTS HARC: Evidence for a non-calorigenic effect of thyroxin on erythropoiesis as judged by radioiron utilization. Proc. Soc. Exp. Biol. Med. 117: 520, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT M. DONATI, M.D.; MARY ANNE WARNECKE, B.S.; NEIL I. GALLAGHER, M.D.Affiliations: St. Louis, MissouriFrom the Department of Internal Medicine, St. Louis University School of Medicine and the Radioisotope Laboratory, St. Louis Veterans Administration Hospital, St. Louis, Mo.This paper was presented in part at the Meeting of the Southern Section of the American Federation for Clinical Research, New Orleans, La., January, 1965.Requests for reprints should be addressed to Robert M. Donati, M.D., Radioisotope Service, Veterans Administration Hospital, 915 North Grand Blvd., St. Louis, Mo. 63106. 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WAGNER JR., M.D.AN ANALYSIS OF HYPOPLASTIC ANAEMIA WITH SPECIAL REFERENCE TO THE USE OF OXYMETHOLONE (”ADROYD“) IN ITS THERAPYErythropoietic response to isomeres of triiodothyronineHematologic Alteration Associated with Endocrine DiseaseErythrokinetics in MyxedemaJOSEPH M. KIELY, M.D., F.A.C.P., DON C. PURNELL, M.D., F.A.C.P., CHARLES A. OWEN JR., M.D. 1 December 1965Volume 63, Issue 6Page: 945-950KeywordsAnemiaErythropoiesisHormonesHospital medicineHyperthyroidismOxygenRed blood cellsResearch laboratoriesThyroidThyroid hormones ePublished: 1 December 2008 Issue Published: 1 December 1965 PDF downloadLoading ...