tbuckley/cabot-search huggingface dataset:
Etiology of Cerebro-Spinal Meningitis.
Authors: W. H. Ten Broeck
Journal: JAMA (1898)

Paris, Ill., June 27, 1898. <h3>To the Editor:</h3> —I have been very much interested in recent reports and papers on cerebro-spinal meningitis, which I believe is caused by mold. Four of my cases were attacked after eating crackers that had molded and been warmed over by a grocer, and all have been in damp houses during damp weather. A great many cases occur in armies and among those who live in Alaska, where victuals are liable to be moldy. I notice that the straw used by the Third Illinois Infantry was damp. Respectfully,
Evaluation of combined valvular prolapse syndrome by two-dimensional echocardiography.
Authors: S Ogawa, J Hayashi, H Sasaki, M Tani, M Akaishi, H Mitamura, M Sano, T Hoshino, S Handa, Y Nakamura
Journal: Circulation (1982)

The patterns of aortic and tricuspid valve motion in 50 patients with mitral valve prolapse were analyzed by wide-angle, phased-array, two-dimensional echocardiography. Twelve patients (24%) had redundant aortic leaflets bulging into the left ventricular outflow tract during diastole. Eight of 12 patients had aortic regurgitation and seven of 12 had M-mode echocardiographic evidence of aortic valve prolapse. One patient underwent mitral and aortic valve replacement, and the excised valves revealed marked myxomatous degeneration. Eight of 15 patients undergoing contrast echocardiography had tricuspid regurgitation (systolic reflux of contrast material into the inferior vena cava persisting for more than 10 beats), and prolapse in the septal leaflet of the anterior leaflet or both. A similar tricuspid valve pattern was noted in three of seven patients without tricuspid regurgitation. Tricuspid valve prolapse was identified in 20 patients (40%). Nine patients (18%) had combined prolapse of the mitral, aortic and tricuspid valves. In five patients with middiastolic high-pitched murmurs recorded along the left sternal border, tricuspid valve prolapse was demonstrated. In one of these patients, the presence of pulmonary regurgitation was confirmed by intracardiac phonocardiography. We conclude that two-dimensional echocardiography is useful for evaluating patients with combined valvular prolapse syndrome.
NURSING AND NURSES IN WAR.
Authors: N. SENN
Journal: JAMA (1899)

One of the grave problems of modern warfare is the proper care and nursing of the sick and wounded. Our recent experience during the war with Spain has brought the subject prominently to the attention of the military authorities and the people of the United States. The war just ended has furnished the most instructive and forcible object-lesson, in demonstrating the importance and necessity of making adequate preparation for the proper care and management of the disabled soldiers in war time. The motives which precipitated the war were of the purest, noblest kind, arising from the desire to bring freedom and liberty to the legitimate owners of our neighboring islands, who, under the iron rule of an effete, bankrupt monarchy, had been deprived of their liberty, happiness and prosperity for centuries. On our part, the war spirit was aroused by a sense of duty to our neighbors and to advance
Mid-Arm Sentinel Lymph Nodes Showing Surprising Drainage From a Malignant Melanoma in the Forearm
Authors: SERGI VIDAL-SICART, FRANCESCA PONS, JORDI PIULACHS, TERESA CASTEL, JOSEP PALOU, RAMON HERRANZ
Journal: Clinical Nuclear Medicine (1998)

A 51-year-old man with a malignant melanoma in his left forearm was studied to detect the sentinel lymph node and to assess the possibility of micrometastases in regional lymph nodes. Lymphoscintigraphy demonstrated two sentinel lymph nodes in the midarm. Two other nodes in the same location as well as in the left axilla were also observed. The exact location of the sentinel lymph nodes was identified with a gamma-ray detector. At the time of surgery, blue dye was injected around the primary lesion and the two sentinel lymph nodes on the inner side of the left arm were resected. Both lymph nodes were pigmented black. The histopathologic study demonstrated metastases from malignant melanoma in both nodes. This case reflects the main role of lymphoscintigraphy in identifying draining lymph nodes in unusual locations as observed in this patient.
851 GENETIC PREDICTORS OF STEATOSIS AND FIBROSIS IN NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
Authors: A. Mangia, L. Mottola, D. Petruzzellis, V. Piazzolla, M. Garrubba, R. Di Paola, R. Santoro, V. Trischitta, M. Vilella, R. Fanelli, E. Vanni, D. Seripa, A. Pilotto, E. Bugianesi, M. Guido, S.A. Santini
Journal: Journal of Hepatology (2011)
Dietary Fat and Reduced Prostate Cancer Mortality
Authors: Stephen J. Freedland
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Adhesive and hydrophobic properties of Escherichia coli from the rectal mucosa of patients with ulcerative colitis.
Authors: M G Hartley, M J Hudson, E T Swarbrick, A E Gent, M D Hellier, R H Grace
Journal: Gut (1993)

The adherent properties and hydrophobicity of Escherichia coli isolates have been compared from the rectal mucosa of patients with active and inactive ulcerative colitis and from a control patient group. Patients with active colitis were colonised less frequently and with lower numbers of E coli than were control patients. Mannose resistant adhesion to HEp-2 cells was determined for 124 isolates of E coli and surface hydrophobicity was estimated by salt agglutination in 96 of these isolates. There was no significant difference in the distribution of adherent strains between the colitis patient groups or with disease activity. E coli from the control patients were marginally less adhesive than those from colitics. The hydrophobicity of isolates did not differ significantly between colitic and control groups nor were there significant differences correlated with disease activity. Furthermore, for these mucosal E coli isolates, hydrophobicity and mannose resistant adhesion were unrelated characteristics.
National Data on the Epidemiology of IDDM in Greece: Cases diagnosed in 1992
Authors: Catherine Dacou-Voutetakis, Kyriaki Karavanaki, Helen Tsoka-Gennatas
Journal: Diabetes Care (1995)

To detect the incidence, geographic distribution, and seasonal variation of insulin-dependent diabetes mellitus (IDDM) in all of Greece.One hundred and thirty-seven children (75 boys and 62 girls) up to 14.9 years of age were diagnosed with IDDM in Greece in 1992.The age-adjusted incidence of IDDM in Greece in 1992 was 6.25/100,000 population (boys: 6.17/100,000;: girls: 6.28/100,000). There was a significant pubertal peak. The incidence of IDDM was significantly higher in metropolitan (10.0/100,000) than in rural (4.21/100,000), semirural (7.48/100,000), or urban areas (5.36/100,000) of Athens. There was a marginal difference between rural and semirural areas. No significant seasonal variation in the incidence of IDDM was observed.We conclude that the incidence of IDDM in Greece is among the five lowest in Europe. An impressive clustering of cases was observed in the Athens metropolitan area compared with the rural and semirural areas, an observation that possibly underlines the importance of environmental factors (stressful situations, infections, dietary habits, and others) in the expression of IDDM.
Identification of Differentially Expressed Genes in Hepatocellular Carcinoma With Cdna Microarrays
Authors: Yukihiro Shirota, Shuichi Kaneko, Masao Honda, Hiroshi F. Kawai, Kenichi Kobayashi
Journal: Hepatology (2001)

Genes expressed in hepatocellular carcinoma (HCC) were analyzed using cDNA microarrays to clarify gene abnormalities in HCC. mRNA was extracted from cancerous and noncancerous tissues of 10 patients with HCC, cDNA labeled with Cy5 and Cy3 fluorescence was prepared, and it was hybridized for each patient with a cDNA microarray consisting of 1,080 elements (930 unique genes). The mRNA expression rate of each element in HCC was evaluated using the level of mRNA expression in noncancerous tissue in each patient as a reference. The expression of 10 genes was enhanced 2 times or more in HCC cancerous tissue compared with noncancerous tissue in 5 or more of the 10 patients. In contrast, 9 genes were expressed at half the level or less in HCC cancerous tissue compared with noncancerous tissue. When hierarchical clustering was performed to identify genes related to clinical phenotypes of the patients, 22 genes showed changes associated with the degree of differentiation of HCC. Thirteen of these genes were transcriptional factors or tissue-specific expression proteins related to cell differentiation or development. Our present analysis clarified a number of genes that characterize HCC. This information based on examination of clinical samples is considered to be useful for clarification of the mechanism of hepatocarcinogenesis and the diagnosis and treatment of HCC.
Childhood Acute Lymphocytic Leukemia
Authors: W. A. Smithson, G. S. Gilchrist, E. O. Burgert
Journal: CA A Cancer Journal for Clinicians (1980)

At present, significant numbers of children with ALL enjoy prolonged survival without serious sequelae. All children should be given the benefit of treatment under the supervision of physicians experienced in childhood cancer. Risk factors should be properly assessed and children at high risk placed in innovative programs. Longterm follow-up of patients is essential to detect, as early as possible, potentially prohibitive toxicity.
HYPNOTISM NOT A GAIN.
Authors: H. L. GREEN
Journal: JAMA (1896)

To the ordinary orthodox medical student the production of hypnotism may immediately arouse the thought of some tangible, comprehensible agent, such as chloral, chloroform, ether or sulphonal, something if not ponderable and palpable, yet perceptible in some way. The laity generally ascribe the power of the hypnotist to an imaginary animal magnetism. Electricity, which has been classed imponderable, can be felt; and why also should not this claimed potency have its volts and milliamperes? To the scientific student or psychologist this vague claim is too mystic, savoring too much of the imagination and is found in the present onward trend of knowledge, not to have a sufficient basis. Hypotism, in the opinion of the writer, can mean only a more or less perfect sleep having its expression primarily in the condition, physiologic and pathologic of the brain and nervous system; secondarily in other parts of the body system. The mind
Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy
Authors: Anna Shteingauz, Ilanit Boyango, Inna Naroditsky, Edward Hammond, Maayan Gruber, Ilana Doweck, Neta Ilan, Israel Vlodavsky
Journal: Cancer Research (2015)

Heparanase is the only enzyme in mammals capable of cleaving heparan sulfate, an activity implicated in tumor inflammation, angiogenesis, and metastasis. Heparanase is secreted as a latent enzyme that is internalized and subjected to proteolytic processing and activation in lysosomes. Its role under normal conditions has yet to be understood. Here, we provide evidence that heparanase resides within autophagosomes, where studies in heparanase-deficient or transgenic mice established its contributions to autophagy. The protumorigenic properties of heparanase were found to be mediated, in part, by its proautophagic function, as demonstrated in tumor xenograft models of human cancer and through use of inhibitors of the lysosome (chloroquine) and heparanase (PG545), both alone and in combination. Notably, heparanase-overexpressing cells were more resistant to stress and chemotherapy in a manner associated with increased autophagy, effects that were reversed by chloroquine treatment. Collectively, our results establish a role for heparanase in modulating autophagy in normal and malignant cells, thereby conferring growth advantages under stress as well as resistance to chemotherapy. Cancer Res; 75(18); 3946-57. ©2015 AACR.
Effect of selective PDGF-receptor versus non-selective protein tyrosine kinase blockers on aortic smooth muscle cells (SMC's) and endothelial cells proliferation
Authors: Shmuel Banai, Aviva Schneider, S.David Gertz, Gershon Golomb, Alexander Levitzki, Yehuda Wolf
Journal: Journal of the American College of Cardiology (1996)
Are We Getting Informed Consent from Patients with Cancer?
Authors: H J Sutherland, G A Lockwood, J E Till
Journal: Journal of the Royal Society of Medicine (1990)

We developed a consent form for a hypothetical trial and asked patients to underline information that was pertinent to their decision to accept or refuse to participate in the proposed trial. We also investigated whether patients correctly interpreted statements describing the probability of certain events occurring. Of the 50 patients, 74% did not indicate that both risks and benefits were pertinent. Of the 20 patients who would not enter the trial, 70% focused on risks of therapy only. In contrast, of the 30 who agreed to enter, only 33% focused entirely on risks, while 10% did not note potential for either benefit or risk. For each of four probability statements, patients chose one of four possible interpretations, only one of which was correct. Depending on the statement, between 26 and 54% of the interpretations were incorrect. It appears that many decisions regarding trial entry may be based upon incomplete or incorrect information.
Enhanced Ventricular Untwisting During Exercise
Authors: Yuichi Notomi, Maureen G. Martin-Miklovic, Stephanie J. Oryszak, Takahiro Shiota, Dimitri Deserranno, Zoran B. Popovic, Mario J. Garcia, Neil L. Greenberg, James D. Thomas
Journal: Circulation (2006)

The cascade of events by which early diastolic left ventricular (LV) filling increases with exercise is not fully elucidated. Doppler tissue imaging (DTI) can detect myocardial motion, including torsion, whereas color M-mode Doppler (CMM) can quantify LV intraventricular pressure gradients (IVPGs).Twenty healthy volunteers underwent echocardiographic examination with DTI at rest and during submaximal supine bicycle exercise. We assessed LV long-/short-axis function, torsion, volume, inflow dynamics, and early diastolic IVPG derived from CMM data. LV torsion and untwisting velocity increased with exercise (torsion, 11+/-4 degrees to 24+/-8 degrees ; untwisting velocity, -2.0+/-0.7 to -5.6+/-2.3 rad/s) that was associated with an increase in IVPG (1.4+/-0.5 to 3.7+/-1.2 mm Hg). Untwisting in normal subjects occurred during isovolumic relaxation and early filling, significantly before long-axis lengthening or radial expansion. The clinical feasibility of this method was tested in 7 patients with hypertrophic cardiomyopathy (HCM); torsion was higher at rest but did not increase with exercise (16+/-4 degrees to 14+/-6 degrees), whereas untwisting was delayed and unenhanced (-1.6+/-0.8 to -2.3+/-1.2 rad/s). In concert, IVPG was similar at rest (1.2+/-0.3 mm Hg), but the exercise response was blunted (1.6+/-0.8 mm Hg). In normal subjects and HCM patients, there was a similar linear relation between IVPG and untwisting rate, with an overall correlation coefficient of r=0.75 (P<0.0001).LV untwisting appears to be linked temporally with early diastolic base-to-apex pressure gradients, enhanced by exercise, which may assist efficient LV filling, an effect that appears blunted in HCM. Thus, LV torsion and subsequent rapid untwisting appear to be manifestations of elastic recoil, critically linking systolic contraction to diastolic filling.
P351 TNFα CLEAVING ENZYME (TACE/ADAM 17) IS AN IMPORTANT DRIVER OF CHOLESTASIS-ASSOCIATED LIVER INJURY AND SICKNESS BEHAVIOR DEVELOPMENT
Authors: H.H. Nguyen, C. D'Mello, S.J. Urbanski, T.S. Le, T. Le, M.G. Swain
Journal: Journal of Hepatology (2014)
Lactated Ringer's Injection In Hemorrhagic Shock
Authors: Robert M. Hardaway
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The concept, recommended by Shires<sup>1</sup>and Moyer,<sup>2</sup>that administration of saline or lactated Ringer's injection along with limited amounts of blood is superior to complete replacement by blood in the treatment of hemorrhagic shock is, in my opinion, based on a misinterpretation of data derived from experiments on dogs. I agree with Moyer<sup>2</sup>that the administration of lactated Ringer's injection plus a small amount of the removed blood is superior to administration of all the removed blood in the treatment of experimental hemorrhagic shock in dogs.<sup>3,4</sup>However, it is not the Ringer's injection per se that produces this good effect. It is the absence of the shed blood which, by its treatment out of the body, has in some way been altered to promote disseminated intravascular coagulation (DIC) in the presence of shock and a slow, stagnant blood flow.<sup>3,4</sup>If care is
High‐dose cytosine arabinoside and idarubicin treatment of chronic myeloid leukemia in myeloid blast crisis
Authors: Steven Barone, Maria R. Baer, Sheila N.J. Sait, David Lawrence, AnneMarie W. Block, Meir Wetzler
Journal: American Journal of Hematology (2001)

Abstract Chronic myeloid leukemia in myeloid blast crisis (CML‐MBC) is highly resistant to standard induction chemotherapy regimens. Anecdotal results from previous clinical trials support the concept of dose escalation in patients with CML‐MBC. Eight patients with CML‐MBC were treated with cytosine arabinoside (Ara‐C) 1.5–3.0 g/m 2 intravenously over 1 hr every 12 hr for 12 doses and idarubicin 12 mg/m 2 intravenously daily for 3 days. Sixteen previous reports describing the use of Ara‐C‐based chemotherapy regimens in patients with CML‐MBC were also reviewed. Our patients' median age was 62 years (range, 42–69 years). One patient achieved complete hematologic remission (95% confidence interval, 0.3%, 53%). The median survival for our patients was 7.3 months. These results were not different from previous published reports using Ara‐C‐based chemotherapy regimens to treat CML‐MBC. In summary, the combination of high‐dose Ara‐C and idarubicin did not improve the overall prognosis of patients with CML‐MBC. Innovative approaches need to be explored for this patient population. Am. J. Hematol. 67:119–124, 2001. © 2001 Wiley‐Liss, Inc.
Asbestos-induced lung disease.
Authors: A R Brody
Journal: Environmental Health Perspectives (1993)

This review attempts to deal with two major questions concerning asbestos-induced lung disease: How does inhaled asbestos cause cell proliferation and fibrosis? and Will there continue to be risk from exposure to asbestos in schools and public buildings? The first is a scientific question that has spawned many interesting new experiments over the past 10 years, and there appear to be two hypothetical schemes which could explain, at least in part, the fibroproliferative effects of asbestos fibers. One supports the view that toxic oxygen radicals generated on fiber surfaces and/or intracellularly are the central mediators of disease. The second hypothesis is not mutually exclusive of the first, but, in my opinion, may be integral to it, i.e., the cellular injury induced by oxygen radicals stimulates the elaboration of multiple varieties of growth factors and cytokines that mediate the pathogenesis of asbestosis. There is increasing evidence that molecules such as platelet-derived growth factor and transforming growth factor beta, both synthesized and secreted by activated lung macrophages, are responsible, respectively, for the increased interstitial cell populations and extracellular matrix proteins that are the hallmarks of asbestos-induced fibrosis. The challenge today is to establish which combinations of the many factors released actually are playing a role in disease pathogenesis. The issue of continued risk currently is more a question of policy and perception than science because a sufficient database has not yet been established to allow full knowledge of the circumstances under which asbestos in buildings constitutes an ongoing health hazard. The litigious nature of this question does not help its resolution. In as much as public policy statements and risk assessment are not within my purview, I have focused on the state-of-the-art of asbestos as a complete carcinogen. It appears to be generally nongenotoxic, but all asbestos fiber types can induce chromosomal mutations and aneuploidy, perhaps through their ability to disrupt normal chromosome segregation.
Work Adjustment Five to Ten Years after Bilateral Prefrontal Lobotomy
Authors: Milton Greenblatt, Marie Wingate, Harry C. Solomon
Journal: New England Journal of Medicine (1954)

THE lobotomy operation for the treatment of mental illness has been used at the Boston Psychopathic Hospital since October, 1943. The first 450 patients received bilateral prefrontal lobotomy (developed by Dr. James L. Poppen and his associates at the Lahey Clinic). To assess the effectiveness of this method of treatment groups of patients have been followed, and various aspects of their adjustment have been studied. A careful clinical follow-up study of the first 250 cases, one to four years after operation, has already been presented.1 Another follow-up study was done five years postoperatively on the first 100 patients who received . . .
456 OSTEOPONTIN, A PUTATIVE MARKER FOR DUCTULAR REACTION, IS INDUCED BY JAK/STAT3 ACTIVATION IN HUMAN BILIARY EPITHELIAL CELLS
Authors: A. Komori, T. Uemura, S. Fujiwara, Y. Aiba, M. Nakamura, H. Fujioka, K. Yano, K. Migita, H. Yatsuhashi, H. Ishibashi
Journal: Journal of Hepatology (2008)