tbuckley/cabot-search huggingface dataset:
REMARKS ON THE METROPOLITAN HOSPITAL SUNDAY FUND: Delivered at the Mansion House on the occasion of the Hospital Sunday Fund Presenting to the Mansion House a Bust of the late Mr. George Herring
Authors: H. Morris
Journal: BMJ (1908)

JZLY 25,'1908-'] 1~~~~~~~~~~~~~~~~~MZDWCAL JOUFMAL'29 wenh a sufficient dose of morphine, as they did, that would not have been the case.It would not have interfered with the experiment.At the moment the chloroform .was removed the morphine would have prevented the animal suffering any pain.He was sure the animal was fast asleep.Colonel Lawrie's animals distinctly showed pain by struggling.In their case not even he was able to say tbat there was any movement.-In reply to Dr. Wilson, he said it was not a question of the influence of chloroform.It was a question of -proving the action of chloroform; -that was all.The chloroform was not given as an anaesthetic then; it was given to test the action of chloroform.Complete narcosis was induced in both .animalsduring the crucial operation by the amount of MOrphine -that had been given.And, as Dr. Shore had onplained also, by the previous administration of A.C.E. and chloroform.In reply to the Chairman, he said Sir Thoma,s Clifford Allbutt was present on the 11th, but not on-the 7th.He was ill, and not able to be there, but he -had sent a letter and a certificate.
A Decree against Inappropriate Medical Care in Italy
Authors: Aldo Mariotto
Journal: Annals of Internal Medicine (2003)

Letters2 December 2003A Decree against Inappropriate Medical Care in ItalyAldo Mariotto, MDAldo Mariotto, MDFrom Health Authority Isontina, 34170 Gorizia, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-11-200312020-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:On 4 March 2003, the Official Gazette of the Republic of Italy published Decree-Law number 32, Urgent Provisions To Counter Unlawful Practice in the Health Care Sector (1). These provisions were issued by the president of the Republic of Italy in consideration of the exceptional need and urgency to issue provisions to more incisively repress unlawful practice within the health care sector, in the light of recent events that have been cause for serious upset and justified concern among the public.Article 1 stated:The competent administrative authority shall inflict , even on grounds of gross negligence, ...References1. Decreto-Legge N. 32. Urgent provisions to counter unlawful practice in the health care sector. Gazzetta Ufficiale della Repubblica Italiana. 4 March 2003; 52:5-6. Google Scholar2. Shekelle PG, Kahan JP, Bernstein SJ, Leape LL, Kamberg CJ, Park RE. The reproducibility of a method to identify the overuse and underuse of medical procedures. N Engl J Med. 1998;338:1888-95. [PMID: 9637810] CrossrefMedlineGoogle Scholar3. Naylor CD. Grey zones of clinical practice: some limits to evidence-based medicine. Lancet. 1995;345:840-2. [PMID: 7898234] CrossrefMedlineGoogle Scholar4. Brook RH, Chassin MR, Fink A, Solomon DH, Kosecoff J, Park RE. A method for the detailed assessment of the appropriateness of medical technologies. Int J Technol Assess Health Care. 1986;2:53-63. [PMID: 10300718] CrossrefMedlineGoogle Scholar5. Naylor CD. What is appropriate care? [Editorial]. N Engl J Med. 1998;338:1918-20. [PMID: 9637815] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Aldo Mariotto, MDAffiliations: From Health Authority Isontina, 34170 Gorizia, Italy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAmicus Brief for 54 International and Comparative Law Experts from 27 Countries and the Marriage and Family Law Research Project 2 December 2003Volume 139, Issue 11Page: 958KeywordsBehaviorClinical pathologyCrimeHealth careHealth care facilitiesHealth care providersHealth care sectorHospitalsMedical servicesReproducibility ePublished: 2 December 2003 Issue Published: 2 December 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Association between Neutrophil to Lymphocyte Ratio and Presence of Ventricular Premature Contractions
Authors: Abdulkadir Yıldız, Murat Yuksel, Mustafa Oylumlu, Nihat Polat, Halit Acet, Mehmet Zihni Bilik, Mesut Aydin, Mehmet Ata Akil, Faruk Ertas, Hasan Kaya, Mehmet Ali Elbey, Ebru Tekbas, Yahya Islamoglu
Journal: Journal of the American College of Cardiology (2013)
Colonic Perforation after Exchange Transfusion
Authors: J. J. Corkery, V. Dubowitz, J. Lister, A. Moosa
Journal: BMJ (1968)

Four patients are reported in whom perforation of the colon followed exchange transfusion for haemolytic disease of the newborn. This association seems to be more than coincidental, and possibly the perforation is due to a vascular accident occurring as a mechanical result of the exchange transfusion. The insidious onset of colonic perforation may be recognized early by the passage of blood per rectum. There is no place for conservative treatment, and once the diagnosis has been made treatment must include broad-spectrum antibiotics and laparotomy.
Doctors' groups are criticised for endorsing pro-industry guidelines
Authors: S. Arie
Journal: BMJ (2013)

An attempt to bring closer collaboration between doctors and the drug industry has had to be abandoned because of unbridgeable differences between the two sides.

The Ethical Standards in Health and Life Sciences Group (ESHLSG), a high profile attempt at partnership between medical royal colleges, leading industry bodies, academics, the BMA, and the NHS Confederation, has told the BMJ it is disbanding.

The decision came after criticism of the group for publishing guidance on collaboration between healthcare professionals and the drug industry and on clinical trial transparency that included several statements that were pro-industry and not considered to be based on evidence.1

The author and campaigner Ben Goldacre condemned “the great and the good” in the medical world for having endorsed the guidelines, saying that they had given false reassurance to patients and professionals on some of the most important problems facing medicine today.

However, Tim Evans of the Royal College of Physicians said that the group had been useful. “The group has reached a time when it needs to change and evolve into something …
Talking to patients about cancer
Authors: R. Buckman
Journal: BMJ (1996)

Talking to patients about cancer No excuse nowfor not doing it __ An extraordinary thing about the medical profession is that it managed to avoid telling the truth to patients for so many cen- turies.In 1672 the French physician Samuel de Sorbiere con- sidered the idea but thought that it might seriously jeopardise medical practice and concluded that it would not catch on.'This approach-recognising the need to act but finding excuses not to-is still in evidence today, even though there has been a considerable change over the past 35 years.Two papers in this week's journal remind us that what is comfortable for clinicians is not necessarily what patients want.
Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells
Authors: Toshihiro Mitaka, Fumihiko Sato, Toru Mizuguchi, Takeshi Yokono, Yohichi Mochizuki
Journal: Hepatology (1999)

Hepatic cells isolated from an adult rat liver, consisting of small hepatocytes (SHs), mature hepatocytes (MHs), liver epithelial cells (LECs), Kupffer cells, sinusoidal endothelial cells, and stellate cells, were cultured in a medium supplemented with 10% fetal bovine serum, 10 mmol/L nicotinamide, 1 mmol/L ascorbic acid 2-phosphate, 10 ng/mL epidermal growth factor, and 1% dimethyl sulfoxide. The SHs rapidly proliferated and formed a colony. About 10% of cytokeratin 8 (CK8)-positive cells formed SH colonies. All SHs at day 10 immunocytochemically showed positivity for albumin, transferrin, CK8, and CK18, which are markers for hepatocytes. In contrast, alpha-fetoprotein (AFP)-, CK14-, OC2-, and glutathione S-transferase placental type (GST-P)-positive cells, which are thought to be markers for hepatic immature cells, were rarely observed. At day 20 some cells in the colonies were positive for AFP, CK7, CK19, and GST-P. LECs and stellate cells proliferated and surrounded the colonies. About 2 weeks after plating, piled up cells were often observed on the SH colonies. In those colonies LECs and stellate cells invaded under the colonies. The invasion of the cells and gradual deposits of extracellular matrix (ECM) such as type I collagen, type IV collagen, and laminin induced alteration of the shape of the SHs from relatively flat to cuboidal or rectangular. With the cellular structural changes, the expression of albumin, connexin 32 (Cx32), and tryptophan 2,3-dioxygenase (TO) messenger RNAs increased. In addition, overlapping nonparenchymal cells (NPCs) on the piled up cells induced the formation of duct- or cyst-like structures consisting of MHs. In the present experiment we showed that SHs could differentiate to MHs by interacting with NPCs and ECM. Thus, SHs may be "committed progenitor cells" that can further differentiate into MHs.
Effect of tranilast on restenosis after coronary angioplasty
Authors: Tomoya Onodera, Akinori Takizawa, Man-Sok Kim, Hiroyuki Fukita, Akihiko Uehara, Tsuyoshi Urushida, Masaki Matsunaga, Takeshi Yoneda, Shinzo Miyamoto, Tomoyuki Kubota
Journal: Journal of the American College of Cardiology (1996)
Petrarch, physicians, and controlled trials
Authors: Olivier Nardi
Journal: BMJ (2004)

selective emphasis of particular results and inappropriate adjustment for confounders. 12The relatively small secular changes in mean birth weight (from -11 g to 94 g for the different groups) between our two cohorts would not by themselves explain the magnitude of decreases in blood pressure.Alterations in salt intake may be important.In adolescents randomised in infancy to a low or a normal sodium diet systolic and diastolic blood pressure were lower after 15 years in those in the intervention arm, suggesting that sodium restriction in infancy may have greater effects on later blood pressure than salt reductions in adulthood, 13 and although these findings are based on incomplete follow up, they are, nevertheless, provocative.Our observations suggest that several of the major determinants of adult blood pressure are set in train in early life.It is therefore encouraging that blood pressure levels seem to have fallen over time in this population, and there are likely to be considerable public health benefits in such a population decrease if it is sustained into adult life.
Toward Removing the Barricade to Psychiatric Clinic Availability
Authors: ROBERT T. CORNEY, WILLIAM H. GREY
Journal: American Journal of Psychiatry (1970)

Screening evaluation, allowing the clinic patient ready access to the psychiatrist and to treatment, proved useful at the University of Virginia Hospital mental health clinic and seemed an adequate first experience for patients. It eliminated the waiting list and became the first step in a crisis-oriented treatment program for many. For others living far from the clinic, it made realistic the use of local caregiving resources, as the psychiatrist remained available for consultation and reevaluation.
Benzene, an experimental multipotential carcinogen: results of the long-term bioassays performed at the Bologna Institute of Oncology.
Authors: C Maltoni, A Ciliberti, G Cotti, B Conti, F Belpoggi
Journal: Environmental Health Perspectives (1989)

In 1976, a systematic and integrated project of long-term carcinogenicity bioassays began at the Bentivoglio Experimental Unit of the Bologna Institute of Oncology. The Bologna experiments proved for the first time that benzene is an experimental carcinogen. These experiments demonstrated that benzene is carcinogenic when administered by ingestion and by inhalation and that it cause tumors in the various tested animal models (Sprague-Dawley rats, Wistar rats, Swiss mice, and RF/J mice). They also showed that benzene is a multipotential carcinogen, as it produces a variety of neoplasias in one or more of the tested animal models, including Zymbal gland carcinomas, carcinomas of the oral cavity, nasal cavities, skin, forestomach, and mammary glands, as well as angiosarcomas of the liver, hemolymphoreticular neoplasias, tumors of the lung, and possibly hepatomas. The Bologna experiments also indicated a clear-cut dose-response relationship in benzene carcinogenesis. This report presents the up-to-date results of the Bologna project. The need for more experimental research aimed at assessing the carcinogenic effects of low doses of benzene, of chemical mixtures containing benzene, and of benzene substitutes is emphasized. Also recommended are more comprehensive epidemiological investigations, extended to all types of malignancies, with particular regard to lung carcinomas.
Gene Transfer of Human Prostacyclin Synthase Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats
Authors: Noritoshi Nagaya, Chieko Yokoyama, Shingo Kyotani, Manabu Shimonishi, Ryuichi Morishita, Masaaki Uematsu, Toshio Nishikimi, Norifumi Nakanishi, Toshio Ogihara, Masakazu Yamagishi, Kunio Miyatake, Yasufumi Kaneda, Tadashi Tanabe
Journal: Circulation (2000)

Background —Prostacyclin is a potent vasodilator that also inhibits platelet adhesion and cell growth. We investigated whether in vivo gene transfer of human prostacyclin synthase (PGIS) ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats. Methods and Results —The cDNA encoding PGIS was intratracheally transfected into the lungs of rats by the hemagglutinating virus of Japan–liposome method. Rats transfected with control vector lacking the PGIS gene served as controls. Three weeks after MCT injection, mean pulmonary arterial pressure and total pulmonary resistance had increased significantly; the increases were significantly attenuated in PGIS gene–transfected rats compared with controls [mean pulmonary arterial pressure, 31±1 versus 35±1 mm Hg (−12%); total pulmonary resistance, 0.087±0.01 versus 0.113±0.01 mm Hg · mL · min − 1 · kg − 1 (−23%), both P &lt;0.05]. Systemic arterial pressure and heart rate were unaffected. Histologically, PGIS gene transfer inhibited the increase in medial wall thickness of peripheral pulmonary arteries that resulted from MCT injection. PGIS immunoreactivity was intense predominantly in the bronchial epithelium and alveolar cells. Lung tissue levels of 6-keto-PGF 1α , a stable metabolite of prostacyclin, were significantly increased for ≥1 week after transfer of PGIS gene. The Kaplan-Meier survival curves demonstrated that repeated transfer of PGIS gene every 2 weeks increased survival rate in MCT rats (log-rank test, P &lt;0.01). Conclusions —Intratracheal transfer of the human PGIS gene augmented pulmonary prostacyclin synthesis, ameliorated MCT-induced pulmonary hypertension, and thereby improved survival in MCT rats.
Calcipotriol for erythema annulare centrifugum
Authors: R. Gniadecki
Journal: British Journal of Dermatology (2002)

Erythema annulare centrifugum (EAC) is an uncommon inflammatory skin disease of unknown aetiology. No therapy is currently available. We describe a 73-year-old woman with a 3-year history of EAC that was resistant to topical and systemic glucocorticoids, antifungals, and psoralen plus ultraviolet A treatment. After 3 months of treatment with topical calcipotriol the lesions cleared completely and did not recur during a 6-month follow-up period. Vitamin D analogues may be of value in the therapy of EAC.
Electroencephalogram during and after an Acute Attack of Asthma in Children
Authors: J. P. Issakainen, M. J. Koivikko, V. K. Häkkinen
Journal: Allergy (1982)

EEGs were recorded in 12 children who were admitted to hospital because of an asthmatic attack. One EEG was recoiled during the attack, one immediately after, and it third EEG several weeks later, The severity of the attack was classified as moderate in eight children, severe in three and very severe in one child, There was a corresponding change in the blood gases, but other laboratory values (electrolytes, glucose, etc.) were normal. Contrary to previous findings, no change was seen in the three successive EEG recordings which had been related to die mucks. It is therefore concluded that an asthmatic attack as such does not give rise to changes in the EEG, and a complicating factor should he suspected if such changes are seen.
Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity.
Authors: Susan K Vilcheck, Travis J O'Brien, Daryl E Pritchard, Linan Ha, Susan Ceryak, Jamie L Fornsaglio, Steven R Patierno
Journal: Environmental Health Perspectives (2002)

Fanconi anemia (FA) is an autosomal recessive disorder characterized by diverse developmental abnormalities, progressive bone marrow failure, and a markedly increased incidence of malignancy. FA cells are hypersensitive to DNA cross-linking agents, suggesting a general defect in the repair of DNA cross-links. Some forms of hexavalent chromium [Cr(VI)] are implicated as respiratory carcinogens and induce several types of DNA lesions, including ternary DNA-Cr-DNA interstrand cross-links (Cr-DDC). We hypothesized that human FA complementation group A (FA-A) cells would be hypersensitive to Cr(VI) and Cr(VI)-induced apoptosis. Using phosphatidylserine translocation and caspase-3 activation, human FA-A fibroblasts were found to be markedly hypersensitive to chromium-induced apoptosis compared with CRL-1634 cells, which are normal human foreskin fibroblasts (CRL). The clonogenicity of FA-A cells was also significantly decreased compared with CRL cells after Cr(VI) treatment. There was no significant difference in either Cr(VI) uptake or Cr-DNA adduct formation between FA-A and CRL cells. These results show that FA-A cells are hypersensitive to Cr(VI) and Cr-induced apoptosis and that this hypersensitivity is not due to increased Cr(VI) uptake or increased Cr-DNA adduct formation. The results also suggest that Cr-DDC may be proapoptotic lesions. These results are the first to show that FA cells are hypersensitive to an environmentally relevant DNA cross-linking agent.
TCT-339 Comparison of 12-month Clinical Outcomes in Patients with Chronic Total Occlusion (CTO) Lesion between Diabetic and Non-Diabetic: A Multicenter Study of e-CTO Investigators
Authors: Cheol Ung Choi, Young Keun Ahn, In ho Chae, Jin Ho Choi, Seong Woo Han, Yang soo Jang, Woong Cheol Kang, Jin Won Kim, Byoung Keuk Kim, Seung Jin Lee, Seung Hwan Lee, Hong Euy Lim, Jin oh Na, Dong Joo Oh, Chang Gyu Park, Jong Seon Park, Seung-Woon Rha, Hong Seog Seo, Cheol woong Yu, Seong Il Im, Sun Won Kim
Journal: Journal of the American College of Cardiology (2012)
Comparative Neurobiological and Neuropsychological Deficits in Adolescent and Adult Schizophrenic and Nonschizophrenic Patients
Authors: Louis A. Gottschalk, Carole Selin
Journal: Psychotherapy and Psychosomatics (1991)

A group of 24 adolescents and young adults were classified according to four measures using Research Diagnostic Criteria on the dimension of the severity of their schizophrenic syndrome. Independent assessments by the Gottschalk-Gleser Social Alienation-Personal Disorganization Scale and the Abrams-Taylor Emotional Blunting Scale corroborated that the definite schizophrenic group (n = 7) was significantly more schizophrenic than the not schizophrenic group (n = 12), but not more so than the probably schizophrenic group (n = 5). The Halstead-Reitan Category Test and Rhythm Test significantly differentiated the definite schizophrenic group from the not schizophrenic group with respect to cognitive impairment. The Gottschalk-Gleser Cognitive Impairment Scale did not indicate a significant difference in cognitive function between these patient groups. The computerized EEG revealed a significantly higher percent of EEG abnormalities among the definite and probably schizophrenic groups than the not schizophrenic group of patients. These findings are analyzed and discussed.
New approach to organ transplantation based on the fetal allograft.
Authors: R Finn, C A St Hill
Journal: BMJ (1978)

A new approach to organ transplantation that may be particularly applicable to kidney transplantation is suggested by analogy with the immunological mechanism responsible for the survival of the fetal allograft. The method concerns identifying donor-recipient tissue compatibility by use of the two-way mixed lymphocyte reaction (MLR), in which reacting cells from patients awaiting transplants are primed with phytohaemagglutinin (PHA) and stored. When a donor becomes available, these PHA-primed cells may then be tested against donor lymphocytes, possibly giving a result within 36 hours. Immunosuppressive agents occurring naturally in pregnancy, such as alpha-fetoprotein and chorionic gonadotrophin, may eventually replace standard immunosuppressive treatment with potentially toxic regimens in transplant recipients. If the results of the two-way MLR using PHA-primed cells are shown to be comparable to those of the standard two-way MLR graft survival may be successful in 80% of cases.
Parallel Visual Information Processing Test
Authors: Michèle Montreuil, R. Roland, J. Jouvent, Solange Carton, Catherine Bungener, Daniel Widlöcher
Journal: Psychotherapy and Psychosomatics (1991)

A novel clinical and experimental situation has been created, based on the psychopathological concepts of 'pensée opératoire' and alexithymia and the contribution of recent trends in cognitive science as to the dual skills of the brain hemispheres: the Parallel Visual Information Processing Test. This test was validated in more than 100 subjects, and revealed that holistic visual attention is reduced during logical task performance; this impairment appeared to be typical of patients with poor fantasizing ability and operative behavior. Such findings are consistent with some authors' theory according to which there is a functional commissurotomy in alexithymic and psychosomatic patients.
Prognosis of heart failure patients with reduced and preserved ejection fraction and coexistent chronic obstructive pulmonary disease
Authors: Beom‐June Kwon, Dong‐Bin Kim, Sung‐Won Jang, Ki‐Dong Yoo, Keun‐Woong Moon, Byung Ju Shim, Seo‐Hee Ahn, Eun‐Ju Cho, Tae‐Ho Rho, Jae‐Hyung Kim
Journal: European Journal of Heart Failure (2010)
A CASE OF CAISSON DISEASE, OR DIVERS' PARALYSIS, TREATED WITH COMPRESSED AIR
Authors: W. H. Perry
Journal: JAMA (1923)

On the afternoon of March 3, 1922, O. T., a deep sea diver employed by a wrecking company of New London, Conn., was stricken with complete loss of power of the lower extremities half an hour following an ascent from a dive in 95 feet of water. He had worked on the bottom for an hour and ten minutes, and was brought to the surface in less than four minutes. Symptoms appeared fifteen minutes after the removal of the diving dress. He first noticed incoordination in walking, and a feeling of weakness in both legs. Half an hour after the ascent he had completely lost control of the lower extremities. From his own statement, there were no areas of anesthesia. There was retention of urine. There was no headache, vomiting or dyspnea. So far as we were able to determine, the patient did not experience the customary pains in the