Heterologous Fat Transplantation for the Treatment of HIV-Related Facial Lipoatrophy
Authors: Giovanni Guaraldi, Nicola Squillace, Domenico De Fazio, Tullio Prestileo, Frank Palella
Journal: Annals of Internal Medicine (2009)

Letters6 January 2009Heterologous Fat Transplantation for the Treatment of HIV-Related Facial LipoatrophyGiovanni Guaraldi, MD, Nicola Squillace, MD, Domenico De Fazio, MD, Tullio Prestileo, MD, and Frank Palella, MDGiovanni Guaraldi, MDFrom the University of Modena and Reggio Emilia, 41100 Modena, Italy; Casa Di Cura Salus Hospital, 42100 Reggio Emilia, Italy; Casa del Sole Hospital, 90100 Palermo, Italy; and Northwestern University Feinberg School of Medicine, Chicago, IL 60610.Search for more papers by this author, Nicola Squillace, MDFrom the University of Modena and Reggio Emilia, 41100 Modena, Italy; Casa Di Cura Salus Hospital, 42100 Reggio Emilia, Italy; Casa del Sole Hospital, 90100 Palermo, Italy; and Northwestern University Feinberg School of Medicine, Chicago, IL 60610.Search for more papers by this author, Domenico De Fazio, MDFrom the University of Modena and Reggio Emilia, 41100 Modena, Italy; Casa Di Cura Salus Hospital, 42100 Reggio Emilia, Italy; Casa del Sole Hospital, 90100 Palermo, Italy; and Northwestern University Feinberg School of Medicine, Chicago, IL 60610.Search for more papers by this author, Tullio Prestileo, MDFrom the University of Modena and Reggio Emilia, 41100 Modena, Italy; Casa Di Cura Salus Hospital, 42100 Reggio Emilia, Italy; Casa del Sole Hospital, 90100 Palermo, Italy; and Northwestern University Feinberg School of Medicine, Chicago, IL 60610.Search for more papers by this author, and Frank Palella, MDFrom the University of Modena and Reggio Emilia, 41100 Modena, Italy; Casa Di Cura Salus Hospital, 42100 Reggio Emilia, Italy; Casa del Sole Hospital, 90100 Palermo, Italy; and Northwestern University Feinberg School of Medicine, Chicago, IL 60610.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-1-200901060-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Clinical features of HIV-1–related lipodystrophy prominently include facial lipoatrophy. These abnormalities can adversely affect the psychological well-being of HIV-infected individuals, affecting adherence to antiretroviral drug regimens, body self-image, and overall quality of life (1, 2).Objective: To evaluate heterologous fat transplant to treat facial lipoatrophy in a set of HIV-serodiscordant homozygous twins and discuss its possible pathogenetic implications.Case Report: We transplanted abdominal subcutaneous fat from twin 1, the HIV-seronegative donor, to the subcutaneous cheek region of twin 2, the HIV-infected recipient, by using the Coleman technique (3). Twin 2 had been HIV-infected for 18 years and was extensively ...References1. Ammassari A, Antinori A, Cozzi-Lepri A, Trotta MP, Nasti G, Ridolfo AL, et al; AdICoNA Study Group. LipoICoNA Study Group. Relationship between HAART adherence and adipose tissue alterations. J Acquir Immune Defic Syndr. 2002;31 Suppl 3 S140-4. [PMID: 12562038] CrossrefMedlineGoogle Scholar2. Guaraldi G, Orlando G, Murri R, Vandelli M, De Paola M, Beghetto B, et al. Quality of life and body image in the assessment of psychological impact of lipodystrophy: validation of the Italian version of assessment of body change and distress questionnaire. Qual Life Res. 2006;15:173-8. [PMID: 16411042] CrossrefMedlineGoogle Scholar3. Coleman SR. Structural fat grafts: the ideal filler? Clin Plast Surg. 2001;28:111-9. [PMID: 11248861] CrossrefMedlineGoogle Scholar4. Fliers E, Sauerwein HP, Romijn JA, Reiss P, van der Valk M, Kalsbeek A, et al. HIV-associated adipose redistribution syndrome as a selective autonomic neuropathy. Lancet. 2003;362:1758-60. [PMID: 14643128] CrossrefMedlineGoogle Scholar5. van Gurp PJ, Tack CJ, van der Valk M, Reiss P, Lenders JW, Sweep FC, et al. Sympathetic nervous system function in HIV-associated adipose redistribution syndrome. AIDS. 2006;20:773-5. [PMID: 16514309] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of Modena and Reggio Emilia, 41100 Modena, Italy; Casa Di Cura Salus Hospital, 42100 Reggio Emilia, Italy; Casa del Sole Hospital, 90100 Palermo, Italy; and Northwestern University Feinberg School of Medicine, Chicago, IL 60610.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNutrition and the HIV-associated lipodystrophy syndromeClinical management of HIV-associated lipodystrophy 6 January 2009Volume 150, Issue 1Page: 61-63KeywordsAntiretroviralsDrug adherenceDrugsFatsGeneticsLipodystrophyPathogensSurgeryTransplantationTwins ePublished: 6 January 2009 Issue Published: 6 January 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...