Retinoid Therapy for Rheumatoid Arthritis
Authors: EDWARD D. HARRIS
Journal: Annals of Internal Medicine (1984)

Editorials1 January 1984Retinoid Therapy for Rheumatoid ArthritisEDWARD D. HARRIS JR., M.D.EDWARD D. HARRIS JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-146 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEffective therapeutic intervention in the course of rheumatoid arthritis often involves using more than one class of drugs. This use of polypharmacologic therapy is not surprising considering the complex pathophysiologic process of the disease. In rheumatoid arthritis, acute inflammation, manifested by large numbers of polymorphonuclear leukocytes in the synovial fluid and activation of the clotting, kinin, and fibrinolytic systems, is matched both by chronic inflammation involving macrophages and lymphocytes in the synovium and by enormous proliferation of synovial cells capable of generating enzymes that destroy cartilage, tendon, and bone. Indeed, because of the aggressive manner in which it destroys joints,...References1. HARRISEVANSONDIBONAKRANE EJDS. Collagenase and rheumatoid arthritis. Arthritis Rheum. 1970;13:83-94. CrossrefMedlineGoogle Scholar2. SPORNHARRIS ME. Proliferative diseases. Am J Med. 1981;70:1231-5. CrossrefMedlineGoogle Scholar3. EVANSONJEFFREYKRANE JJS. Human collagenase: identification and characterization of an enzyme from rheumatoid synovium in culture. Science. 1967;158:499-502. CrossrefMedlineGoogle Scholar4. DAYERKRANERUSSELLROBINSON JSRD. 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BRINCKERHOFFCOFFEYSULLIVAN CJA. Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis-retinoic acid. Science. 1983;221:756-8. CrossrefMedlineGoogle Scholar10. BRINCKERHOFFHARAOUIALLENSPORNHELFGOTTWILDER CBJMRR. Dose-dependent suppression by 4-hydroxy-phenyl retinamide of streptococcal cell wall arthritis in rats (Abstract). Clin Res. 1983. (In press). Google Scholar11. SPORNROBERTS MA. Role of retinoids in differentiation and carcinogenesis. Cancer Res. 1983;43:3034-40. MedlineGoogle Scholar12. DONERKOEFFLER DH. Retinoic acid-inhibition of the clonal growth of human myeloid leukemia cells. J Clin Invest. 1982;69:277-83. CrossrefMedlineGoogle Scholar13. LIBBYBERTRAM PJ. Lack of intracellular retinoid-binding proteins in a retinol-sensitive cell line. Carcinogenesis (Lond.) 1982;3:481-4. CrossrefMedlineGoogle Scholar14. RASMUSSEN H. Calcium & cAMP as Synarchic Messengers. New York: John Wiley & Sons, Inc; 1981. Google Scholar15. WINDHORSTNIGRA DT. General clinical toxicology of oral retinoids. J Am Acad Dermatol. 1982;6:675-82. CrossrefMedlineGoogle Scholar16. SPEARMULLER KS. Treatment of cystic acne with 13-cis-retinoic acid. Mayo Clin Proc. 1983;58:509-14. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Medicine and Dentistry of New Jersey-Rutgers Medical School New Brunswick, New Jersey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySpecialized Treatment Approaches and Niche Therapies for Lupus SubsetsThe Effect of Retinoids on Haemopoiesis-Clinical and Laboratory StudiesIn vitro effect of retinoids on calcineurin activityN-[4-hydroxyphenyl] retinamide in rheumatoid arthritis: A pilot studyThe secretion of the tissue inhibitor of metalloproteinases (TIMP) by human synovial fibroblasts is modulated by all-trans-retinoic acidComparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and lewis lung carcinoma cellsProcollagen gene expression by scleroderma fibroblasts in culture. inhibition of collagen production and reduction of proα(i) and proα1(III) collagen messenger RNA steady-state levels by retinoidsAre rheumatoid arthritis and systemic lupus erythematosus inversely related diseases?Effects of Specific Nutrients on the Immune Response: Selected Clinical ApplicationsRegulation of the Mammalian CollagenasesThe Remote Effects of Rheumatic Diseases on the Hand, and Their Management 1 January 1984Volume 100, Issue 1Page: 146-147KeywordsDrug therapyEnzymesInflammationLymphocytesMedical servicesNeutrophilsRetinoidsRheumatoid arthritisSynovial fluidTendons Issue Published: 1 January 1984 PDF downloadLoading ...