tbuckley/cabot-search huggingface dataset:
Correlation between Effects of Ouabain on the Canine Electrocardiogram and Transmembrane Potentials of Isolated Purkinje Fibers
Authors: MICHAEL R. ROSEN, HENRY GELBAND, BRIAN F. HOFFMAN
Journal: Circulation (1973)

Isolated canine Purkinje fiber bundles (PF) were perfused with the blood of intact donor dogs to correlate changes induced by ouabain (O) in the PF transmembrane potential (TP) and the donor ECG. O was administered intravenously to the donor, and standard microelectrode technics were used to record the TP. The only significant O effect prior to occurrence of toxic arrhythmias was induction of ST-T wave changes in the ECG and prolongation of action potential duration (APD). Early O toxicity was defined as the onset of junctional or ventricular premature contractions or junctional tachycardia. Simultaneous with early toxicity there were decreases in AP amplitude, resting membrane potential, maximal slope of phase O depolarization, APD, and plateau, and slowing of conduction, which often varied in extent from cycle to cycle. With increased duration of early toxicity or onset of late toxicity (ventricular tachycardia), TP changes were accentuated. Increased automaticity occurred at the time of early toxicity when plasma potassium concentration ([K + ] o ) &lt; 4 mEq/liter. In three of seven instances in which [K + ] o &gt; 4.0 mEq/liter, low amplitude potentials were recorded during phase 4. The possible role of these potentials in relation to the generation of toxic arrhythmias is discussed.
Contraceptives and serum proteins.
Authors: M H Briggs, M Briggs
Journal: BMJ (1970)

In response to a report by L.W. Powell and others of a study in which it was shown that single intramuscular injections of 300 mg medroxyprogesterone acetate lasting 120-180 days did not elevate serum levels of iron or of total iron-binding  capacity (TIBC) as did sequential orals leading to the conclusion that the elevations were due to the estrogenic rather than progestogenic component a preliminary report of another study is presented.  In this investigation oral estrogen and progestogen were given separately and in combination to groups of 10-12 women.  The compounds were given in gelatin capsules or as proprietary preparations daily for 3-4 weeks.  A combined oral contraceptive containing ethinylestradiol 50 mcg and norethisterone acetate 1000 mcg (i.e. Minovlar) produced a significant increase in serum iron TIBC and serum copper values.  Ethinylestradiol given alone in doses up to 50 mcg significantly increased serum copper values but not serum iron or TIBC.  Norethisterone acetate had a marked effect on serum iron and TIBC but only a slight action on serum copper.  D(j)-norgestrel increased serum iron and TIBC but had no effect on serum copper.  The findings suggests that oral estrogens have no marked effects on serum iron and TIBC but that oral progestogens stimulate an increase.  This is in contrast to the conclusion of Dr. Powell and others.  The possible explanation of the difference might be the route of administration of the steroid.
The Relationship of the REM State to Analytical Psychology
Authors: THOMAS B. KIRSCH
Journal: American Journal of Psychiatry (1968)

A brief review of Jung's approach to dreams is presented. The author reviews four investigations of REM research that relate to analytical psychology: control of sleep by a dual mechanism; selective REM deprivation; effects of drugs on the time of dreaming; and the study of REM state in the earliest stage of postnatal life. This renewed interest may provide a new methodology for the study of dreams.
Further Observations on Vaccination in Infancy with Oral Poliomyelitis Vaccine and Diphtheria, Tetanus, Pertussis Vaccine
Authors: N. R. Butler, P. F. Benson, J. Urquhart, A. P. Goffe, G. J. Knight, T. M. Pollock
Journal: BMJ (1964)

Antiseptic skin care of infants with a 3 % hexachlorophane emulsion is shown to be a very effective method of reducing puerperal breast abscess in mothers.
Allergens causing bird fancier's asthma
Authors: I. Tauer‐Reich, G. Fruhmann, A. B. Czuppon, X. Baur
Journal: Allergy (1994)

The study investigates to what extent bird feathers contain relevant allergens/antigens involved in bird fancier's asthma. The study group consisted of two budgerigar fanciers, two parrot fanciers and one canary fancier. All subjects complained of asthmatic symptoms, caused by contact with their birds, and they showed a significant bronchial hyperreactivity to acetylcholine. Positive IgE antibody reactions to bird sera as well as to extracts of feathers were observed in RAST. Well-defined major allergenic bands could be detected and identified in the IgE immunoblots with feather extracts as well as with serum proteins of budgerigar, parrot, pigeon, canary, and hen (mol. mass 20-30 kDa and 67 kDa). The most pronounced bands appeared with the extracts of species to which an exposure had taken place. Weaker IgG-binding patterns were also observed. Our results show that inhalable feather dust contains several allergenic components which cross-react with serum allergens/antigens of the same as well as of other bird species. This emphasizes the significance of bird feathers for immediate-type allergic reactions.
Dermatological conditions in HIV infection.
Authors: M M Walker, C E Griffiths, J Weber, J N Leonard, S M Forster, A V Powles, J R Harris, R J Clayton
Journal: BMJ (1987)

Dermatological conditions are often the presenting feature of the acquired immune deficiency syndrome (AIDS) and include Kaposi's sarcoma and opportunistic infections.Kaposi's sarcoma is the initial presentation ofAIDS in over one quarter ofhomosexual men, though it is less common in other groups.'-3Opportunistic infections may be disseminated and present as skin lesions from which they can be diagnosed.45Patients with AIDS and related syndromes have a high incidence of seborrhoeic eczema" and, less commonly, folliculitis," vasculitis," and viral and fungal conditions.'2Various unclassifiable conditions have also been described.'3Oral manifestations include candidiasis, malignancy, and oral hairy leucoplakia."MThe large number of patients infected by the human immunodeficiency virus (HIV) at this hospital prompted us to establish a joint venereology and dermatology clinic to investigate the dermato- pathology of HIV related disease.To date 146 patients have been seen, all homosexual men.Thirty patients had AIDS,' 16 48 had persistent generalised lymphadenopathy,'7 and 68 were asympto- -^6 w ~~~~~~~~~~~~~~~~~~~~~~~~~: r : FIl 1-Braise like Kaposi's sarcoma (patch stage) on hed.Histological diagnosis can be difficult at this stage."
Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers
Authors: Henry M. Dunnenberger, Kristine R. Crews, James M. Hoffman, Kelly E. Caudle, Ulrich Broeckel, Scott C. Howard, Robert J. Hunkler, Teri E. Klein, William E. Evans, Mary V. Relling
Journal: The Annual Review of Pharmacology and Toxicology (2014)

Although the field of pharmacogenetics has existed for decades, practioners have been slow to implement pharmacogenetic testing in clinical care. Numerous publications describe the barriers to clinical implementation of pharmacogenetics. Recently, several freely available resources have been developed to help address these barriers. In this review, we discuss current programs that use preemptive genotyping to optimize the pharmacotherapy of patients. Array-based preemptive testing includes a large number of relevant pharmacogenes that impact multiple high-risk drugs. Using a preemptive approach allows genotyping results to be available prior to any prescribing decision so that genomic variation may be considered as an inherent patient characteristic in the planning of therapy. This review describes the common elements among programs that have implemented preemptive genotyping and highlights key processes for implementation, including clinical decision support.
Abstract LB-94: Highly specific and sensitive detection of BRAF and KRAS mutations in tumor samples
Authors: Anjali Mishra, Sergey Chupreta, Ron Beaubien, Laurie Kurihara, Vanessa Kelchner, Julie LaLiberte, Andrey Mikheykin, Vladimir Makarov
Journal: Cancer Research (2012)

Abstract The development of highly sensitive and specific mutation detection assays that are suitable for clinical and laboratory research opens up new opportunities in the fields of cancer diagnostics and therapeutics. Swift Biosciences has developed myT™ Primer technology which has unique structural and thermodynamic properties that enable highly sensitive mismatch discrimination. Real-time PCR assays using myT Primers are able to detect 1% mutant BRAF V600E/K or mutant KRAS (codons 12A, 12R, 12C, 12V, 12S, 12D and 13D) present in a background of 103 wild-type genomic DNA copies. Notably there is no non-specific amplification from wild-type. The extreme selectivity and reproducibility of such assays results in a definitive Yes/No answer and eliminates the need to use a delta Ct method to call positives. myT Primer specific reagents are well suited for genotyping and have been tested on FFPE samples derived from melanoma, colorectal and lung tumors and their corresponding normal adjacent samples, and are also effective on fresh frozen tissues. A separate ultrasensitive version of myT Primers has also been developed. The ultrasensitive myT Primers format enables the detection of a single mutant copy of BRAF or KRAS in &amp;gt; 104 wild-type genomic DNA copies, representing 0.01% detection; again, non-specific amplification from wild-type was not observed. The myT Primer ultrasensitive reagents are ideal for use when sample sizes are limiting such as in needle biopsies, CTCs, and serum. myT Primers are compatible with Roche LC480, ABI 7500 and Bio-Rad CFX96 real-time PCR instruments as well as different PCR master mixes. Thus the use of myT Primer reagents will allow for better detection, evaluation and monitoring of cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-94. doi:1538-7445.AM2012-LB-94
Observer variation in grading sacroiliac radiographs might be a cause of 'sacroiliitis' reported in certain disease states.
Authors: H Yazici, M Turunc, H Ozdogan, S Yurdakul, A Akinci, C G Barnes
Journal: Annals of the Rheumatic Diseases (1987)

Radiological sacroiliitis in Behçet's syndrome (BS) has been a subject of controversy. We have examined pelvic radiographs of 38 patients with BS and 28 age and sex matched controls which we reported previously, and also 17 with ankylosing spondylitis (AS), 27 with non-renal familial Mediterranean fever (FMF), and 33 with primary osteoarthrosis (OA). Initially, five observers assessed radiographs on two different occasions according to the New York criteria for sacroiliitis in a blind protocol. Later, three of them examined the various possible abnormalities of the sacroiliac (SI) joints after training sessions. Although the inter- and intraobserver variation was quite high, all observers found the expected changes in patients with AS. The abnormalities detected in the other diseases were either mild, inconsistent, or both. Erosions were confined to patients with AS, and osteophytes and glenoid sulci to patients with OA. We conclude that high observer variation in interpreting a film of the anteroposterior (AP) view of the pelvis for sacroiliitis may be a major cause of reported 'sacroiliitis' in BS and FMF.
Targeted gene delivery into peripheral sensorial neurons mediated by self-assembled vectors composed of poly(ethylene imine) and tetanus toxin fragment c
Authors: Hugo Oliveira, Ramon Fernandez, Liliana R. Pires, M. Cristina L. Martins, Sérgio Simões, Mário A. Barbosa, Ana P. Pêgo
Journal: Journal of Controlled Release (2010)
Neuropharmacology of the Pancreatic Islets
Authors: P H Smith, D Porte
Journal: The Annual Review of Pharmacology and Toxicology (1976)

Following the discovery that insulin and glucagon are produced by the pancreatic islets, a vast literature has accumulated concerning the role of substrates, non pan­ creatic hormones, and intracellular factors in the control of islet hormone release. The results of such work are the subject of several reviews (1-4) and therefore are not covered in-depth in this paper. More recently, however, it has been appreciated that the nervous system is also intimately involved in the regulation of endocrine pancreatic secretion. The purpose of this review is to discuss the anatomic, physi­ ologic, and pharmacologic evidence for the role of neural factors in the regulation of insulin and glucagon secretion, and to demonstrate that the endocrine pancreas is an important neuroendocrine organ.
The Family of Guanylyl Cyclase Receptors and Their Ligands
Authors: JAMES G. DREWETT, DAVID L. GARBERS
Journal: Endocrine Reviews (1994)

IN 1963, shortly after the discovery of cAMP (1–5), Ashman et al. (6) identified cyclic-GMP (cGMP) in rat urine. Reports soon followed showing that various agents including neurotransmitters and hormones elevated cGMP concentrations in many different cells (for review see Ref. 7). In 1969, three laboratories discovered the enzyme, guanylyl cyclase (8–11). Initial expectations that the enzyme would be regulated in much the same manner as its already exciting sibling, adenylyl cyclase, met with immediate problems. These included the localization of guanylyl cyclase to both the particulate and soluble fractions of cell homogenates, and multiple experimental failures to activate the enzyme in broken cell preparations by agents known to elevate cGMP levels in intact cells. As a consequence, much of the earliest work on guanylyl cyclase concentrated on descriptive features of the soluble and particulate forms. In the mid-1970s, three studies (12–14) provided the first evidence that guanylyl cyclase activities present in the soluble and particulate fractions of cell homogenates appeared to be due to different proteins.
TCT-253 Calling 911 Anywhere Best Determines Reduction in Total Ischemia Time in ST-Elevation Myocardial Infarction (STEMI)
Authors: Bryan H. Wilson, John Cedarholm, Angela D. Humphrey, William Downey, Glen Fandetti, J. Lee Garvey, Robert Haber, Glen Kowalchuk, Michael Rinaldi
Journal: Journal of the American College of Cardiology (2013)
Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication
Authors: Fulvio Reggiori, Iryna Monastyrska, Monique H. Verheije, Tito Calì, Mustafa Ulasli, Siro Bianchi, Riccardo Bernasconi, Cornelis A.M. de Haan, Maurizio Molinari
Journal: Cell Host & Microbe (2010)
Paraspinal and intraspinal calcinosis: frequent complications in patients with systemic sclerosis
Authors: T Ogawa, T Ogura, K Ogawa, A Hirata, N Hayashi, Y Izumi, E Saito
Journal: Annals of the Rheumatic Diseases (2009)

Soft tissue calcinosis is a common manifestation in patients with systemic sclerosis (SSc), most typically seen as cutaneous calcium deposition in the extremities. By contrast, spinal calcinosis has been the subject of limited reports,1 2 3 4 5 6 7 and its prevalence and disease–phenotype associations have not been discussed.

To clarify this issue, CT of the chest was performed on 41 patients with SSc who fulfilled the preliminary criteria of the American College of Rheumatology and had no history of trauma related to the development of calcinosis (median (SD) age, 60.3 (13.3) (range 28–82) years; women/men: 36/5) with 5 mm slices, and the images were interpreted blindly. All studies were approved by the institutional review board.

Paraspinal calcinosis (PSC) …
Herlitz junctional epidermolysis bullosa: laminin-5 mutational profile and carrier frequency in the Italian population
Authors: M. Castori, G. Floriddia, N. De Luca, M. Pascucci, P. Ghirri, V. Boccaletti, M. El Hachem, G. Zambruno, D. Castiglia
Journal: British Journal of Dermatology (2007)

Herlitz junctional epidermolysis bullosa (HJEB; MIM 226700) is a rare epithelial adhesion disorder caused by null mutations in any of the three genes encoding the alpha3, beta3 and gamma2 chains of laminin-5, and is mainly characterized by extensive mucocutaneous blistering, recurrent infections and early lethality.To perform immunoepitope mapping, electron microscopy and molecular analysis of five Italian patients with HJEB in order to complete the clinical and molecular characterization of patients with HJEB collected in the Italian Registry of hereditary epidermolysis bullosa (IRHEB) and to calculate the HJEB carrier frequency in this population.Skin biopsies from perilesional skin of all patients were employed for immunoepitope mapping and electron microscopy examination. Blood genomic DNA was used for mutation analysis in the LAMA3, LAMB3 and LAMC2 genes by heteroduplex scanning, preceded by a search for Italian recurrent mutations. Carrier frequency calculation was performed assuming Hardy-Weinberg equilibrium.Two novel mutations in the LAMA3 (p.R782X) and LAMC2 (c.3235delA) genes, as well as three known and recurrent mutations in the LAMB3 (c.31insC and p.R81X) and LAMC2 (p.Y355X) genes were identified. Based on disease incidence reported in the IRHEB and the prevalence of mutations in each laminin-5 gene, the population carrier risk for HJEB was calculated to be one in 375.Our delineation of a laminin-5 mutational spectrum in the general Italian population provides a solid basis for expedited diagnosis, accurate genetic counselling and DNA-based prenatal testing for Italian families at risk for recurrence of HJEB.
Clinical trials update: Highlights of the Scientific Sessions of Heart Failure 2001, a meeting of the Working Group on Heart Failure of the European Society of Cardiology. CONTAK‐CD, CHRISTMAS, OPTIME‐CHF
Authors: Simon Thackray, Alison Coletta, Peter Jones, Anita Dunn, Andrew L. Clark, John G.F. Cleland
Journal: European Journal of Heart Failure (2001)
Adenoma screening and colorectal cancer.
Authors: A M Pollock, P Quirke
Journal: BMJ (1991)

enhances the production of rheumatoid factor in mice injected with lipopolysaccharides, a good model for the induction of this autoantibody."There are also interesting ways in which oestrogens may enhance the pathogenicity ofautoantibodies. 12The interactions between gonadal steroids and the immune system are, however, complicated and may result in enhancement or suppression of different immune responses.'3In addition, many of the published data ignore the contrasting effects of regular and cyclic exposure to oestrogens.'4The neuroendocrine system has multiple effects on immune responses, and it is oversimplistic to extrapolate from the experimental results of giving oestrogen to a disease such as rheumatoid arthritis.'5Current ideas about the aetiopathogenesis of autoimmune diseases centre on the genetic control of autoantigen presentation to T lymphocytes by specialised cells,'6 and it is here that sex differences seem most likely to operate.The effects of ovarian steroids on gene expression may prove at least as relevant as those on immune responses.17
Health care in London. Political motives fuel assault on London.
Authors: T H Turner
Journal: BMJ (1993)

exploitation by the imperial powers than any population explosion.Today, as Third World countries become more marginalised in the world economy and less able to maintain debt repayments it is their desperation, poverty, and stagnation that determine their inclusion in the "developing" world.While the world economy leaves millions with no access to clean water or medical or food supplies and pays Western farmers to leave pro- ductive land fallow, Smith highlights the "evidence ... that many women are crying out for access to contraceptives."Population must be kept "on the agenda from the United Nations to the village council," but until the prevailing assumptions are replaced with critical scientific, social, and political investigation there will be no solutions.
139. Priming and Boosting Efficiency of Chimp and Human Adenoviral Vectors in the Setting of Pre-Existing Immunity in Non-Human Primates
Authors: Joanita Figueredo, Roberto Calcedo, Jim Miller, Gary Kobinger, Rebecca Grant, Guangping Gao, James M. Wilson
Journal: Molecular Therapy (2005)

The high prevalence of preexisting immunity against commonly used adenoviral vectors in humans, limits their use as vaccines, especially when re-administration is required. In order to overcome this problem, we have identified and characterized Chimpanzee derived-Adenoviral vectors, to which human exposure is limited, thus enabling their potential use in prime/boost regimens and in the presence of preexisting AdH5 immunity.
Regional Distribution of Pulmonary Ventilation and Perfusion in Obesity *
Authors: H. S. Holley, J. Milic-Emili, M. R. Becklake, D. V. Bates
Journal: Journal of Clinical Investigation (1967)

Five women and three men, all obese and weighing 95 to 140 kg, were studied by routine pulmonary function tests and by a radioactive xenon technique, while seated upright at rest, to measure the regional ventilation and perfusion distribution in the lung. In four subjects in whom the expiratory reserve volume averaged 49% of predicted normal, the ventilation distribution as measured with (133)xenon was normal. In the remaining four subjects, in whom the expiratory reserve volume was reduced to less than 0.4 L and averaged only 21% of predicted values, the distribution of a normal tidal breath was predominantly to the upper zones. In all subjects the perfusion distribution was predominantly to the lower lung zones but was slightly more uniform than in normal nonobese subjects. During tidal-volume breathing, therefore, in four subjects the ventilation and perfusion distribution was substantially normal, whereas in the remaining four perfusion was maximal in the lower zones, to which ventilation was significantly reduced. These findings show that there may be significant ventilation/perfusion abnormality on a regional basis in obese subjects, this abnormality bearing a close relationship to the reduction in expiratory reserve volume, a finding predictable from recently published data on normal nonobese subjects (1). The abnormalities of ventilation/perfusion relationships that were demonstrated in four of the eight obese subjects could cause a reduction in arterial oxygen tension during resting tidal ventilation.