tbuckley/cabot-search huggingface dataset:
A new apex-ejecting perfused rat heart preparation: relation between coronary flow and loading conditions
Authors: J. WIKMAN-COFFELT, R. J COFFELT, M. RAPCSAK, R. SIEVERS, J. L. ROULEAU, W. W PARMLEY
Journal: Cardiovascular Research (1983)

Journal Article A new apex-ejecting perfused rat heart preparation: relation between coronary flow and loading conditions Get access JOAN WIKMAN-COFFELT, JOAN WIKMAN-COFFELT From the Cardiovascular Division of the Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, and the Department of Agricultural Engineering, University of Davis, Davis, California *Address correspondence and reprints to: Joan Wikman-Coffelt, PhD, University of California, San Francisco, California 94143, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT J COFFELT, ROBERT J COFFELT From the Cardiovascular Division of the Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, and the Department of Agricultural Engineering, University of Davis, Davis, California Search for other works by this author on: Oxford Academic PubMed Google Scholar MARIANNE RAPCSAK, MARIANNE RAPCSAK From the Cardiovascular Division of the Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, and the Department of Agricultural Engineering, University of Davis, Davis, California Search for other works by this author on: Oxford Academic PubMed Google Scholar RICHARD SIEVERS, RICHARD SIEVERS From the Cardiovascular Division of the Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, and the Department of Agricultural Engineering, University of Davis, Davis, California Search for other works by this author on: Oxford Academic PubMed Google Scholar JEAN LUCIEN ROULEAU, JEAN LUCIEN ROULEAU From the Cardiovascular Division of the Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, and the Department of Agricultural Engineering, University of Davis, Davis, California Search for other works by this author on: Oxford Academic PubMed Google Scholar WILLIAM W PARMLEY WILLIAM W PARMLEY From the Cardiovascular Division of the Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, and the Department of Agricultural Engineering, University of Davis, Davis, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 17, Issue 12, December 1983, Pages 747–755, https://doi.org/10.1093/cvr/17.12.747 Published: 01 December 1983
Lung Adenocarcinomas with HER2-Activating Mutations Are Associated with Distinct Clinical Features and HER2/EGFR Copy Number Gains
Authors: Chenguang Li, Yihua Sun, Rong Fang, Xiangkun Han, Xiaoyang Luo, Rui Wang, Yunjian Pan, Haichuan Hu, Yang Zhang, William Pao, Lei Shen, Hongbin Ji, Haiquan Chen
Journal: Journal of Thoracic Oncology (2011)
Alcohol Vapor by Inhalation in the Treatment of Acute Pulmonary Edema
Authors: ALDO A. LUISADA, MORTON A. GOLDMANN, RUTH WEYL
Journal: Circulation (1952)

Accepted therapy of pulmonary edema is contraindicated in shock, central nervous system lesions, or pregnancy. Diagnosis of the underlying disease is not always immediately possible. Alcohol inhalation, previously tested in animals, changes surface tension of the foam and has beneficial effects. Clinical experience has revealed prompt relief in over one-half of the acute cases, definite improvement in another 29 per cent. Some cases with subacute edema also exhibited decreased foaming. The absence of contraindications and the possibility of using the method in conjunction with other procedures are favorable elements of alcohol therapy by inhalation.
Pharmacogenetics of psoriasis:<i>HLA-Cw6</i>but not<i>LCE3B/3C</i>deletion nor<i>TNFAIP3</i>polymorphism predisposes to clinical response to interleukin 12/23 blocker ustekinumab
Authors: M. Talamonti, E. Botti, M. Galluzzo, M. Teoli, G. Spallone, M. Bavetta, S. Chimenti, A. Costanzo
Journal: British Journal of Dermatology (2013)

Our understanding of the genetic basis of predisposition to psoriasis is increasing exponentially due to the progress of genetic studies. However, so far little is known about genetic predisposition in relation to the response to psoriasis treatments. Recent data identified genetic predictors for the clinical outcome of conventional treatments such as methotrexate, acitretin and vitamin D derivatives, but few studies are available on genetic predictors of response to biologics. We hypothesized that genetic variations associated with increased risk of developing psoriasis may also act as predictors for the outcome of biologic therapy.The aim of our study was to analyse the presence of three different psoriasis susceptibility genetic variations (HLA-Cw6; TNFAIP3 rs610604 polymorphism; LCE3B/3C gene deletions) in a cohort of patients affected by moderate to severe psoriasis under ustekinumab treatment. Our primary endpoint was to evaluate the association between Psoriasis Area and Severity Index (PASI) 75 response at week 12 and HLA-Cw6 status.Fifty-one patients were genotyped by standard methods and psoriasis severity (PASI score) was evaluated at day 0 and after 4, 12, 24 and 40 weeks of treatment.We observed increased response to ustekinumab in Cw6-positive (Cw6POS) patients [PASI 75 at week 12: 96·4% in Cw6POS vs. 65·2% in Cw6-negative (Cw6NEG) patients; P = 0·008]. In addition, we show that HLA-Cw6POS patients responded faster to ustekinumab, 89·3% of them reaching PASI 50 at week 4, after a single injection (vs. 60·9% of HLA-Cw6NEG patients). The superior response of HLA-Cw6POS patients was maintained throughout the study period, reaching the highest statistical significance for PASI 75 at week 28 (96·35% Cw6POS vs. 72·7% Cw6NEG; odds ratio 9·8). Analysis of TNFAIP3 rs610604 polymorphism and LCE3B/3C gene deletions did not show any significant association with response to ustekinumab.Our observations underline the role of HLA-Cw6 not only as a psoriasis susceptibility gene, but also as a pharmacogenetic marker of response to ustekinumab in psoriasis.
Cerebrovascular Diseases Associated with the Use of Oral Contraceptives
Authors: ALFONSE T. MASI
Journal: Annals of Internal Medicine (1970)

Clinical reports suggest that the use of oral contraceptives predisposes to migraine-like headache and transient or completed cerebral ischemic syndromes in otherwise healthy young women. Vertebrobasilar artery distribution stroke, previously considered rare in young women, was reported in about one fourth of idiopathic stroke patients using oral contraceptives. Limited autopsy studies of previously healthy women dying from stroke and other thromboembolic diseases while using oral contraceptives indicate significant changes in the vascular system as the primary lesion. Controlled retrospective studies of previously healthy young women diagnosed as having cerebral thrombosis indicate an estimated sixfold increased risk of such morbidity and mortality with the use of the oral contraceptives. However, data on cerebrovascular mortality in women of childbearing age indicate no significant change. This lack of overall change may be due to a concurrent reduction in cerebrovascular mortality from other causes.
TCT-243 Comparison of Neointimal Coverage of Everolimus-Eluting Stents and Sirolimus-Eluting Stents: Optical Coherence Tomography Subanalysis from the RESET Trial
Authors: Takashi Akasaka, Takashi Kubo, Yoshihisa Nakagawa, Keiichi Igarashi, Kengo Tanabe, Yoshihiro Morino, Masashi Iwabuchi, Kazuo Kimura, Ken Kozuma, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2012)
Fine mapping of epitopes by intradomain Kd/Dd recombinants.
Authors: J P Abastado, C Jaulin, M P Schutze, P Langlade-Demoyen, F Plata, K Ozato, P Kourilsky
Journal: The Journal of Experimental Medicine (1987)

11 intradomain recombinants between H-2Kd and H-2Dd were produced using an original technique based on in vivo recombination in Escherichia coli. After transfection into mouse L cells, all these recombinants were expressed at high levels on the cell surface. The specificities of 77 mAbs were examined on these cell lines. mAbs could be organized in 12 groups. In each group, a small number of amino acids participating in the recognized epitope(s) were identified. In a few instances, noncontinuous epitopes comprising amino acids belonging to different domains of the antigen were found. The data thus obtained are compatible with those produced in previous exon-shuffling experiments, but permit a much more precise definition of recognized epitope(s).
A CASE OF ANNULAR PAPULAR SYPHILIS IN A NEGRESS
Authors: HOWARD FOX
Journal: JAMA (1913)

It is generally recognized that there are three distinct diseases which are more or less characteristic of the negro race, namely, keloid, elephantiasis and uterine fibroid. It is not so well known that there is a form of cutaneous syphilis, the so-called annular syphilid, which is also strikingly characteristic of the negro. This is an early manifestation of the disease and a modification of the flat papular or discoid syphilid. The lesions apparently begin as flat papules which enlarge peripherally and clear up in the center, forming circular elevated rings. By the coalescence of several rings, various gyrate and festooned patches are produced. The annular syphilid is not only much more frequent in the colored than in the white race, but when present is much more extensive. The eruption is seen most often on the face, but may also occur on the trunk and extremities, especially the back. It appears
Teenager held in Guantanamo denied medical evaluation
Authors: Jeanne Lenzer
Journal: BMJ (2004)

A US judge has ruled that a Canadian teenager held by US forces at Guantanamo Bay naval station does not have the right to a medical or psychiatric evaluation to determine if he is fit to help with his defence. Omar Khadr was captured in Afghanistan in July 2002 in a battle that left a US soldier dead. Mr Khadr, 15 years old at the time, was seriously injured. No charges have been filed against Khadr in the two and a half years that he has been held at Guantanamo Bay.
Postcoital Water Flush In the Prevention of Urinary Tract Infection
Authors: Richards P. Lyon
Journal: JAMA (1971)

To the Editor.—  The incidence of acute cystitis in women rises strikingly once regular intercourse begins, and there can be little doubt that intercourse and infection go together. As urologists, we have recognized a pattern to this problem and hopefully have devised a simple and effective prevention.  In most cases, the symptoms of acute cystitis do not appear for 36 hours after intercourse. It is important that the patient be told of this relationship. The idea that infection takes place in one evening and that the symptoms appear the next morning seems to be fallacious. When the rapid onset of symptoms does occur, we assume that an abnormality is present in the urethra.  It is our impression that a woman usually voids on going to bed, probably emptying her bladder, and then has intercourse within the next hour. With intercourse, massage of the urethra beneath the pubic symphysis takes place,
Antidepressant Treatment for Postnatal Depression
Authors: Emma Molyneaux, Kylee Trevillion, Louise M. Howard
Journal: JAMA (2015)

<h3>Clinical Question</h3> Are antidepressants associated with improved outcomes for postnatal depression? <h3>Bottom Line</h3> Compared with placebo, selective serotonin reuptake inhibitors (SSRIs) are associated with better response and remission rates for postnatal depression. However, few studies included women with severe depression or suicidal ideation. There are insufficient data to conclude whether antidepressants are associated with better outcomes than psychological interventions.
Utility of Recombinant Allergens in the Diagnosis of Patients with Rhinoconjunctivitis and / or Asthma Sensitized to Pollens Cupressus, Platanus, Olea and Phleum
Authors: E. Alejo Almánzar, J.M. Escobar Montalvo, V. Ruiz Sancho, L. Herraez Herrera, A. Enriquez Matas, R. Vives Conesa
Journal: Journal of Allergy and Clinical Immunology (2015)
Carole Anne Alexander
Authors: H. M Dobson, G. Alexander
Journal: BMJ (2009)

On 16 May 2009 we sadly lost our friend and colleague Carole Alexander, consultant radiologist at the West of Scotland Breast Screening Service and the Glasgow Teaching Hospitals.

Educated at Hamilton Academy and then Glasgow University, Carole graduated in 1977, and after house jobs in Hairmyres Hospital, East Kilbride, and the Victoria Infirmary, Glasgow, she embarked on a career in radiology.

At a time when many of her peers were drawn to the more acute specialties, Carole had the foresight to recognise the potential for contributing to patient management that a satisfying career in radiology provides. She embraced all the opportunities offered to her in the West of Scotland training regimen and, having gained her DMRD (London) in 1981, quickly followed by her fellowship (London) in 1983—both at the first attempt—her talents were quickly recognised. At the age of 30, she was appointed consultant to the then Royal Alexandra Infirmary.

Notably, her colleagues, not only in radiology but throughout the clinical specialties, spoke warmly of both her clinical acumen and rapport with all. Within three years she became the consultant in administrative charge, which provided an opportunity for …
Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression.
Authors: T Caulin-Glaser, C A Watson, R Pardi, J R Bender
Journal: Journal of Clinical Investigation (1996)

One of the earliest events in atherosclerosis is interaction of circulating mononuclear leukocytes and the endothelium. Endothelial cell (EC) activation by cytokines results in expression of adhesion molecules and production of chemotactic factors, augmenting leukocyte adhesion and recruitment, respectively. The incidence of atherosclerosis in premenopausal women is significantly less than that observed in age-matched males with similar risk profiles. Because estrogen has gene regulatory effects, we investigated whether 17beta-estradiol (E2) can inhibit cytokine-mediated EC adhesion molecule transcriptional activation. Cultured human umbilical vein EC (estrogen receptor-positive) were propagated in gonadal hormone-free medium and were E2-pretreated for 48 h before IL-1 activation. Detected by FACS analysis, E2 strongly (60-80%) inhibited IL-1-mediated membrane E-selectin and vascular cell adhesion molecule-1 induction, and intercellular adhesion molecule-1 hyperinduction. 17alpha-estradiol (an inactive E2 stereoisomer) had no effect. This inhibition correlated with similar reductions in steady state-induced E-selectin mRNA levels, and was abrogated by the E2 antagonist ICI 164,384, demonstrating a specific, estrogen receptor-mediated effect. Nuclear run-offs confirmed suppression at the transcriptional level. The implications of these results for the cardiovascular protective role of estrogen are discussed.
SOME REMARKS ON SQUINT AND ITS TREATMENT.Read in the Section on Ophthalmology, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: J. H. THOMPSON
Journal: JAMA (1893)

To all observing ophthalmic surgeons it is evident that the common operation for converging squint is by no means perfected, and, I am inclined to think that many of my hearers are willing to join me in the belief, that, of all the operations on the eye, excepting perhaps iridectomy in acute inflammatory glaucoma, that for squint is the most difficult, and yet, there is scarcely a traveling quack or recent postgraduate enthusiast who will not tenotomize a rectus muscle, at any time, on any patient, and for any fee. Some years ago I was regretting the difficulties in this operation in the company of some, of the members of this section, when I was astonished to learn that, for some ophthalmic surgeons the correction of strabismus was child's play and almost beneath the dignity of an eye clinic. Why is this? Because in childhood it is very easy to
Diagnosis of Lesch-Nyhan Syndrome by Direct Study of Skin Specimens
Authors: Phillip Frost
Journal: JAMA (1970)

A molecular diagnosis of the Lesch-Nyhan syndrome was made by the development of an in vivo test of the deficient enzyme. Four patients had studies made with autoradiography of skin biopsy specimens obtained after the intradermal injection of tritium labeled guanine and adenine. Similar results were obtained by incubating skin biopsy specimens of neonatal foreskin in vitro with these precursors. Lesch-Nyhan patients incorporated adenine<sup>3</sup>H, but not guanine<sup>3</sup>H. Control patients incorporated both precursors. Mosaicism was not demonstrable in situ in the obligate heterozygotes studied.
Beneficial Effects of Complement Inhibition With Soluble Complement Receptor 1 (TP10) During Cardiac Surgery
Authors: Harold L. Lazar, Taha Keilani, Carmel A. Fitzgerald, Oz M. Shapira, Curtis T. Hunter, Richard J. Shemin, Henry C. Marsh, Una S. Ryan
Journal: Circulation (2007)

TP10, a potent inhibitor of complement activation during cardiopulmonary bypass (CPB) has been shown to significantly reduce the incidence of death and myocardial infarction (MI) in high-risk male patients undergoing cardiac surgery. However, the effect of TP10 in females was undefined because of the limited number of females studied. To examine the possibility of a gender effect, this phase 2 multi-center trial was undertaken to determine whether TP10 would also limit ischemic damage in a larger sample size of high-risk females undergoing cardiac surgery on cardiopulmonary bypass (CPB).This prospective, double-blind, placebo-controlled, multi-center trial involved 297 high-risk (urgent surgery, CABG + Valve, reoperations, ejection fraction <30%) female patients randomized to receive a 5 mg/kg dose of TP10 (n=150) or placebo (n=147) as a 30-minute intravenous infusion before surgery. The primary end point was the incidence of death or MI at 28 days after surgery. Complement activation was assessed by levels of CH50 and SC5b-9 during and after CPB. TP10 was well tolerated and there were no differences in the safety profiles of the 2 groups. Although TP10 effectively suppressed complement activation (at 2 hours after CPB CH50 (mean+SD % change from baseline) 50+/-17% placebo versus 4+/-14% TP10; P=0.0001; SC5b-9 (ng/mL) 917+/-1067 placebo versus 204+/-79 TP10; P=0.0001), there was no difference in the primary end point between the groups (17% placebo versus 21% TP10; P=0.2550).The benefits of TP10 appear to be gender-related. and mechanisms other than complement activation may be responsible for myocardial injury in high-risk female patients during cardiac surgery on CPB.
Follow-up Study of Chronic Gastric Erosions
Authors: J. Freise, R. Hofmann, M. Gebel, H. Huchzermeyer
Journal: Endoscopy (1979)

Chronic gastric erosions were detected with a frequency of 4.4% in 8,468 patients over the six year period from 1971 to 1977. The lesions were usually multiple, chain-like or clustered, along the greater curvature. The age group most often afflicted was the 50-60 year olds, and male predominance were three to one. In one-third of the cases, chronic erosions were found in combination with gastric or duodenal ulceration. Longterm observation of 64 patients over a period of four and a half years revealed no change in the condition in 50%, increase, decrease or complete disappearance of the lesions were found in the remaining 50%. In 10% chain-like multiple erosions developed into a persisting fold in the gastric mucosa. No evidence suggesting that erosive lesions lead to chronic ulceration or development of either polyps or malignancy within 4 1/2 years was recorded, nor was there any association with gastric protein loss.
Philip Arthur Wilkinson
Authors: N. Wilkinson
Journal: BMJ (2008)

After qualifying, Philip Arthur Wilkinson worked as a house surgeon at Guy’s Hospital and the Derbyshire Royal Infirmary and as senior house surgeon at Harlow Wood before joining the Royal Air Force in 1937. He was posted to RAF Hospital Aden, flying with No 8 Squadron in Vincents. On 3 January 1940 he married Margery Swales, who was in Princess Mary’s Royal Air Force Nursing Service.

In 1941 Philip was posted to RAF Station Kohat in India, flying …
Abstract 2062: The effects of a cell cycle inhibitory peptide fused to elastin-like polypeptide on pancreatic cancer cells with hyperthermia and its combination with gemcitabine.
Authors: Jung Su Ryu, Ana-Matea Mikecin, Drazen Raucher
Journal: Cancer Research (2013)

Abstract Pancreatic cancer is the fourth most common cause of death in United States. Gemcitabine, a pyrimidine nucleoside analogue similar to cytarabine, has been used as a first line treatment for pancreatic cancer since 1997. However, its use has been limited by the side effects such as myelosuppression. So far, many efforts have been made to combine gemcitabine with other drugs, but have failed to prove superior to gemcitabine alone. This work describes the effects of genetically engineered elastin - like polypeptide (ELP) with the p21 Waf1/Cip1 - derived cell cycle inhibitory peptide (p21) on pancreatic tumor cells with or without gemcitabine. ELP is a thermally responsive polypeptide carrier that are soluble in aqueous solutions at physiological temperature (37 °C), but aggregate when the temperature is raised above its transition temperature (Tt, 42 °C). This allows it to be a promising thermally responsive therapeutic carrier that may be actively targeted to solid tumors by application of focused hyperthermia. For this study, we designed p21-ELP conjugates modified with the cell penetrating peptide, Bac, on the C-terminus of ELP. The anti-proliferative activity of p21-ELP-Bac was greater in with the presence of hyperthermia, and the combination therapy with gemcitabine showed the synergism on three pancreatic cancer cells - S2013, Panc-1, and Mia PaCa-2 in vitro. The reduced phosphorylated Rb level and the decrease of S- phase population in tumor cells treated with p21-ELP-Bac conjugates proves that the cytotoxicity which is based on cell cycle inhibition. In the S2013 pancreatic xenograft model, p21-ELP-Bac showed significant tumor growth inhibition in the presence of local hyperthermia; and this tumor growth inhibition was further enhanced upon co-treatment with gemcitabine. This combinatorial effect is expected to alleviate the toxicity of gemcitabine by reducing the dose in the clinics. Overall, our data suggest that thermal targeting of ELP-based therapeutic peptides to the pancreatic cancer cells is an effective and promising treatment strategy, especially in combination with gemcitabine. Citation Format: Jung Su Ryu, Ana-Matea Mikecin, Drazen Raucher. The effects of a cell cycle inhibitory peptide fused to elastin-like polypeptide on pancreatic cancer cells with hyperthermia and its combination with gemcitabine. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2062. doi:10.1158/1538-7445.AM2013-2062
465 LONG TERM RESULTS OF LIVER TRANSPLANTATION FOR WILSON'S DISEASE (WD): THE FRENCH EXPERIENCE
Authors: O. Guilllaud, J. Dumortier, F. Durand, C. Vanlemmens, Y. Calmus, C. Duvoux, N. Kamar, R. Lorho, P. Wolf, P.H. Bernard, G.P. Pageaux, E. Salame, S. Radenne, J. Gugenheim, A. Lachaux, D. Debray, J. Hardwigsen, R. Sobesky, O. Chazouillere, P. Ichai, D. Samuel, J.-C. Duclos-Vallee
Journal: Journal of Hepatology (2010)
Inhibition of MEK/ERK signaling synergistically potentiates histone deacetylase inhibitor-induced growth arrest, apoptosis and acetylation of histone H3 on p21waf1 promoter in acute myelogenous leukemia cell
Authors: C Nishioka, T Ikezoe, J Yang, H P Koeffler, A Yokoyama
Journal: Leukemia (2008)