tbuckley/cabot-search huggingface dataset:
Right superior vena cava draining into the left atrium with left superior vena cava draining into the right atrium.
Authors: D Leys, J Manouvrier, T Dupard, P Kassiotis, C Rey, P Marache, G Ducloux, H Petit
Journal: BMJ (1986)

Right superior vena cava draining into the left atrium with left superior vena cava draining into the right atrium
Inherited prion disease.
Authors: J L Laplanche, J Chatelain, M Dussaucy, C Bounneau, J M Launay, J P Brandel, N Delasnerie-Laupretre
Journal: BMJ (1993)

A 50-year-old man presented with dyspnoea while sitting, standing and walking but resolved completely in supine position. On cardiorespiratory examinations, fine crackles were noted over bibasal area. Chest X-ray showed bilateral reticulonodular shadows, restrictive pattern on spirometry, elevated alveolar arterial O<sub>2</sub> gradient on arterial blood gas. High-resolution CT of the thorax revealed pattern as ‘confident’ or ‘certain’ radiographic diagnosis of idiopathic pulmonary fibrosis (IPF). Bubble-contrast echocardiography in recumbent, sitting and upright positions revealed no intracardiac (right to left shunt) or intrapulmonary shunts. This case highlights the necessity of awareness of this syndrome in cases of interstitial lung diseases (ILDs) also. Although 188 cases have been described thus far of platypnoea-orthodeoxia syndrome (P-OS) of various aetiologies, to the best of our knowledge, it is the first ever case of P-OS in ILD/IPF. Both lung bases were predominantly affected in this patient, platypnoea and orthodeoxia were attributed to areas of low/zero ventilation/perfusion (V/Q) ratio (zone 1 phenomena) as no other obvious explanation was found.
PRIMARY AND SECONDARY LEUCOCYTE CHANGES FOLLOWING THE INTRAMUSCULAR INJECTION OF EPINEPHRINE HYDROCHLORIDE 1
Authors: A. J. Samuels
Journal: Journal of Clinical Investigation (1951)

a normal pituitary gland, the functional capacity of the adrenal cortex may be evaluated. Among the clinical syndromes to which the test may be applicable are hypopituitary states (9), Addison's disease (9, 10) and situations in which a low adrenal reserve may be a threat to the survival of the patient, as during surgery (11). In the literature, therefore, two distinctly different epinephrine tests are described. The test, as utilized by Doan, is based on the immediate response (primary phase) of the circulating
Health Insurance in Households
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of computer generated reminder charts on patients' compliance with drug regimens.
Authors: D K Raynor, T G Booth, A Blenkinsopp
Journal: BMJ (1993)

OBJECTIVE--To investigate whether a reminder chart improved patients9 compliance with their drug regimen after discharge from hospital. DESIGN--Patients were randomly allocated to one of four groups. Two groups received the reminder chart: one also received routine counselling from a nurse and the other received structured counselling from a pharmacist, which included an explanation of the reminder chart. The other two groups received only counseling, either from a nurse or from a pharmacist. Patients were visited about 10 days later: they were questioned about their drug regimen, and their compliance was measured by tablet counting. SETTING--The pharmacy in a district general hospital and patients9 homes. PATIENTS--197 patients being discharged from hospital who were regularly taking two or more drugs. INTERVENTION--An individualised reminder chart, which listed each person9s medicines and when they were to be taken and was automatically generated by a medicine labelling computer. MAIN OUTCOME MEASURES--Patient9s compliance with and knowledge of their drug regimen. MAIN RESULTS--Of the patients who received the reminder chart, 83% (95% confidence interval 74% to 90%) correctly described their dose regimen compared with 47% (37% to 58%) of those without the chart (p &lt; 0.001). The mean compliance score was 86% (81% to 91%) in both groups not given the reminder chart; 91% (87% to 94%) in the group given the chart without an explanation; and 95% (93% to 98%) in the group given the chart and an explanation. A mean compliance score of &gt; 85% was achieved by 63% (53% to 73%) of patients without a reminder chart and by 86% (78% to 93%) of those receiving the chart (p &lt; 0.001). CONCLUSIONS--An automatically generated reminder chart is a practical and cost effective aid to compliance.
Shigellosis. To treat or not to treat?
Authors: Jack B. Weissman, Eugene J. Gangarosa, Herbert L. Dupont, John D. Nelson, Kenneth C. Haltalin
Journal: JAMA (1974)

OPINIONS differ on the most appropriate course of therapy for shigellosis because of conflicting evidence in the literature concerning the efficacy and possible hazards of specific antibiotic therapy. Proponents of specific chemotherapy note that the efficacy of antimicrobial agents in shigellosis is well established.<sup>1</sup>Moreover, several studies have shown that antibiotics will notably decrease the excretion of shigellae in the stools and abbreviate the clinical course of both mild and severe disease.<sup>2,3</sup>Those opposed to specific therapy except in certain special cases argue that the disease is self-limited and usually mild, that strains have repeatedly emerged resistant to whatever antibiotic happened to be in vogue at the time, and that this resistance has frequently been R factor-mediated, resulting in organisms resistant to multiple antibiotics. These viewpoints have recently been summarized.<sup>4</sup> The clinician responsible for deciding whether to prescribe or withhold antimicrobial therapy in an individual case
Amnioplastin: A Warning
Authors: W. Penfield
Journal: BMJ (1940)

This note is intended as a warning against the clinical use of the membrane when improperly prepared.Amnioplastin, which was described in a recent number of the Journal,' is prepared from human amniotic membrane for the purpose of preventing adhesions between dura mater and lacerated brain.In the experiments described by these authors the membrane was soaked in alcohol, followed by boiling in distilled water for twenty minutes.An alternative method was proposed which substituted dry sterilization in the autoclave for the boiling.An unsatis- factory result with membrane prepared by this alternative method must now be reported.
The effect of angiotensin-converting-enzyme inhibitors on progression of advanced polycystic kidney disease
Authors: Tazeen H. Jafar, Paul C. Stark, Christopher H. Schmid, Svend Strandgaard, Anne-Lise Kamper, Giuseppe Maschio, Gavin Becker, Ronald D. Perrone, Andrew S. Levey
Journal: Kidney International (2004)
906. High Efficiency Hepatic Transduction with Minimal Toxicity Following “Hydrodynamic” Injection of HDAd into Nonhuman Primates
Authors: Nicola Brunetti-Pierri, Charles Mullins, Donna Palmer, Milton Finegold, Arthur Beaudet, Karen Rice, Dee Carey, Philip Ng
Journal: Molecular Therapy (2005)

Helper-dependent adenoviral vectors (HDAd) are attractive vectors for liver-directed gene therapy because they can mediate sustained, high level transgene expression with no long-term toxicity. However, as a consequence of a threshold effect, high vector doses are required to achieve efficient hepatic transduction by peripheral intravenous injection which unfortunately results in a dose-dependent activation of the innate inflammatory response. Clearly strategies to overcome the threshold to efficient hepatic transduction are needed to improve the therapeutic index of HDAd. We have recently shown that systemic hydrodynamic injection of HDAd into mice resulted in exceedingly high levels of hepatic transduction and reduction in both systemic vector dissemination and acute proinflammatory cytokines compared to conventional injection. Hydrodynamic injection offers a method of dramatically increasing the therapeutic index of HDAd but, unfortunately, cannot be applied to larger animals due to the large injection volume. Therefore, we have developed a minimally invasive method to mimic hydrodynamic injection in nonhuman primates which does not require injection of large volumes. This method involves the use of balloon occlusion catheters percutaneously positioned in the vena cava to transiently obstruct hepatic venous outflow to increase the intrahepatic pressure prior to simple peripheral intravenous injection of HDAd in a small volume. We demonstrate in nonhuman primates that this novel method of vector delivery results in an exceedingly high and unprecedented level of hepatic transduction with low vector doses resulting in stable, long-term transgene expression. This was accompanied by reduced systemic vector dissemination and minimal, transient elevations of proinflammatory cytokines. Despite the relatively high intrahepatic pressures achieved, there was minimal evidence of liver injury; no histological abnormalities were observed and only minimal and transient elevation of AST and ALT were noted. The procedure itself was uneventful and very well tolerated with no clinical manifestations of acute or chronic toxicities. This novel method of delivering HDAd is simple, minimally invasive, and clinically relevant since it increases the therapeutic index of HDAd for liver-directed gene therapy by allowing high efficiency hepatic transduction with low vector doses and with negligible acute or chronic toxicities.
Breast Milk Dioxins in Hong Kong and Pearl River Delta
Authors: Anthony J. Hedley, Tze Wai Wong, Lai Ling Hui, Rainer Malisch, Edmund A.S. Nelson
Journal: Environmental Health Perspectives (2005)

There are no previous reports from South China on chemically determined polychlorinated dibenzo-para-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs) in human breast milk expressed as World Health Organization (WHO) toxic equivalents (TEQs). In a 2002-2003 WHO exposure study, 13 pools of breast milk comprising samples from 316 primiparous women in Hong Kong in 2002 were analyzed by gas chromatography/mass spectrometry for 29 PCDD/F and dioxin-like PCB congeners. Total WHO-TEQs ranged from 8.97 to 16.7 pg/g fat (weighted mean, 12.9 pg; weighted median, 13.4 pg). Variations in TEQs included positive associations with age (R2 = 0.73, p < 0.0005), higher consumption of dairy products and seafood, and lower TEQs in overseas mothers and ever-smokers. Congener profiles indicated geographic specificity of exposure in Hong Kong, mainland China, and overseas Asian countries, including higher proportions of PCB-TEQs (overseas) and PCDF-TEQs (mainland China). The median TEQs of PCDD/Fs (8.69 pg/g fat) and PCBs (4.73 pg/g fat) in Hong Kong were highest among the five Asian Pacific countries but lower than the levels for at least half of the European countries that participated in the WHO study. However, future international studies should incorporate mother's age in the design of the pooling strategy to allow standardization by other exposure factors and valid comparisons among different countries. The findings allow support for the WHO breast-feeding advisory. Trends in human dioxin levels in the region cannot yet be determined, and rigorous controls are needed to reduce emissions of dioxins and human exposure in mainland China.
A MOTORLESS OXYGEN THERAPY APPARATUS
Authors: Russell L. Cecil
Journal: JAMA (1930)

The value of oxygen therapy in the treatment of disease has been demonstrated in the last decade by the accumulation of extensive clinical and experimental evidence. A continuous supply of from 40 to 60 per cent oxygen has been found to be most beneficial. Administration with the funnel or the nasal catheter does not supply this optimal concentration to the lungs. The mask has been given an extensive trial but has been found unsatisfactory for continuous therapy. The oxygen chambers, as developed by Haldane,<sup>1</sup>Barcroft,<sup>2</sup>Stadie,<sup>3</sup>Binger,<sup>4</sup>Barach,<sup>5</sup>and others, are satisfactory but they are expensive to operate and available only to a few hospital patients. Leonard Hill<sup>6</sup>recognized the importance of constructing a portable oxygen therapy apparatus that would have the advantages of continuous flow and high concentration. In 1921 he described a bed tent that satisfied certain of these requirements but that
Abstract B41: Proteomic characterization of carboplatin resistance in ovarian cancer cells
Authors: Kazimierz O. Wrzeszczynski, Gaofeng Fan, Cexiong Fu, Darryl J. Pappin, Robert Lucito, Nicholas K. Tonks
Journal: Clinical Cancer Research (2013)

Abstract The analysis of quantitative protein expression is necessary for the determination of actual biochemical protein concentrations that can lead to a more accurate description of cellular function. A knowledgebase of cancer function founded on cellular protein levels can more directly implicate potential gene candidates for the detection and treatment of disease. Therefore, we analyzed iTRAQ (Isobaric tag for relative and absolute quantification) data from 11 serous ovarian cancer cell lines and 2 normal ovarian surface epithelial cell lines. We profiled cellular protein abundance in over 2600 proteins with 746 proteins common to all 13 cell lines. Of the 746, 52 proteins exhibited elevated expression and 46 proteins had diminished expression in the cancerous cells when compared to the two normal cell lines. We identified the 300 most variable iTRAQ expressed proteins based on median absolute deviation within 8 carboplatin sensitive and resistant cell lines. Using iTRAQ protein expression profiles from these 300 we successfully segregated the cell lines based on carboplatin sensitivity and resistance measurements. Next, we further examined correlations among iTRAQ protein expression, individual gene RNA expression and DNA methylation data. There was no substantial correlation between protein abundance and RNA expression or epigenetic data. Furthermore RNA expression and DNA methylation data alone did not show any significant discrimination for chemosensitivity or resistance. Our clustering proteomics-based profile used to identify chemotherapy response contained proteins involved in homologous recombination and repair, specifically RPA, MCM2/MCM5 and PALB2. We therefore present the potential of proteomics based discovery for carboplatin response in ovarian cancer and also identify putative gene candidates that may be functionally responsible for chemotherapy response which otherwise would not have been predicted by other singular whole genome data sources. Citation Format: Kazimierz O. Wrzeszczynski, Gaofeng Fan, Cexiong Fu, Darryl J. Pappin, Robert Lucito, Nicholas K. Tonks. Proteomic characterization of carboplatin resistance in ovarian cancer cells. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr B41.
The Dynamically Evolving Nematocyst Content of an Anthozoan, a Scyphozoan, and a Hydrozoan
Authors: Tamar Rachamim, David Morgenstern, Dikla Aharonovich, Vera Brekhman, Tamar Lotan, Daniel Sher
Journal: Molecular Biology and Evolution (2014)

Nematocytes, the stinging cells of cnidarians, are the most evolutionarily ancient venom apparatus. These nanosyringe-like weaponry systems reach pressures of approximately 150 atmospheres before discharging and punching through the outer layer of the prey or predator at accelerations of more than 5 million g, making them one of the fastest biomechanical events known. To gain better understanding of the function of the complex, phylum-specific nematocyst organelle, and its venom payload, we compared the soluble nematocyst's proteome from the sea anemone Anemonia viridis, the jellyfish Aurelia aurita, and the hydrozoan Hydra magnipapillata, each belonging to one of the three basal cnidarian lineages which diverged over 600 Ma. Although the basic morphological and functional characteristics of the nematocysts of the three organisms are similar, out of hundreds of proteins identified in each organism, only six are shared. These include structural proteins, a chaperone which may help maintain venon activity over extended periods, and dickkopf, an enigmatic Wnt ligand which may also serve as a toxin. Nevertheless, many protein domains are shared between the three organisms' nematocyst content suggesting common proteome functionalities. The venoms of Hydra and Aurelia appear to be functionally similar and composed mainly of cytotoxins and enzymes, whereas the venom of the Anemonia is markedly unique and based on peptide neurotoxins. Cnidarian venoms show evidence for functional recruitment, yet evidence for diversification through positive selection, common to other venoms, is lacking. The final injected nematocyst payload comprises a mixture of dynamically evolving proteins involved in the development, maturation, maintenance, and discharge of the nematocysts, which is unique to each organism and potentially to each nematocyst type.
Acute hypertension after traumatic renal artery thrombosis with high circulating concentrations of angiotensin II.
Authors: A Sawyer, C G Isles, J W Dobbie, J P Vance, A F Lever
Journal: BMJ (1982)

clinically yet with an initial serum sodium concentration of 124 mmol/l; she had, however, been drinking large volumes of water before admission.
Indoor Radon and Its Hazards
Authors: Jane M. Orient
Journal: JAMA (1989)

Untold thousands of Americans are daily exposed, in their own homes, to levels of radiation that would cause regulatory agencies to shut down a uranium mine or a nuclear power plant. The average annual dose due to indoor radon is about 300 mrem, compared with 200 mrem from all other sources combined. The level proposed as a target for remedial action is 800 to 4000 mrem/y. In contrast, the total individual (nonoccupational) exposure limit for Department of Energy facilities is 100 mrem/y. This book explains the mechanism for generation and accumulation of radon, describes methods for measuring and reducing its concentration, and examines critically the basis for the Environmental Protection Agency's (EPA) estimate that as many as 20 000 lung cancers per year can be attributed to this naturally occurring substance. Given the uncertainties involved in extrapolating from studies of uranium miners who experienced very high doses, as well as
SYMPTOMATOLOGY OF MULTIPLE SCLEROSIS
Authors: L. HARRISON METTLER
Journal: JAMA (1913)

<h3>Patient.—</h3> Mrs. F., aged 43, married twenty-two years, housekeeper, was seen in consultation with Dr. M. Barker. The father, aged 70, in fine health, does not drink, uses tobacco moderately and never had any severe, prolonged disease. The mother died of consumption when patient was an infant. Brothers and sisters are all healthy. Patient has five well-developed children; never had a miscarriage. <h3>History.—</h3> The patient's birth was natural and she never had convulsions. Childhood was quite uneventful. School life was normal. Menstruation began early and still occurs regularly and painlessly, though rather profusely. The patient was well till fourteen years ago when she experienced an attack of paralysis, first on the left and then on the right side. She remembers a distinct tingling sensation traveling up the legs and arms. No disturbance of consciousness occurred with this attack of paralysis. There was some difficulty in controlling the bowels and she
Fumaric acid esters in severe psoriasis, including experience of use in combination with other systemic modalities
Authors: P. Balasubramaniam, O. Stevenson, J. Berth-Jones
Journal: British Journal of Dermatology (2004)

Journal Article Fumaric acid esters in severe psoriasis, including experience of use in combination with other systemic modalities Get access P. Balasubramaniam, P. Balasubramaniam George Eliot Hospital, Nuneaton CV10 7DJ and Walsgrave Hospital, Coventry CV2 2DX, U.K Search for other works by this author on: Oxford Academic Google Scholar O. Stevenson, O. Stevenson George Eliot Hospital, Nuneaton CV10 7DJ and Walsgrave Hospital, Coventry CV2 2DX, U.K Search for other works by this author on: Oxford Academic Google Scholar J. Berth‐Jones J. Berth‐Jones George Eliot Hospital, Nuneaton CV10 7DJ and Walsgrave Hospital, Coventry CV2 2DX, U.K Dr J.Berth‐Jones, Department of Dermatology, Walsgrave Hospital, University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 4, 1 April 2004, Pages 741–746, https://doi.org/10.1111/j.0007-0963.2004.05739.x Published: 01 April 2004 Article history Accepted: 30 June 2003 Published: 01 April 2004
Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
Authors: Aaron Deykin, Stephen C. Lazarus, John V. Fahy, Michael E. Wechsler, Homer A. Boushey, Vernon M. Chinchilli, Timothy J. Craig, Emily Dimango, Monica Kraft, Frank Leone, Robert F. Lemanske, Richard J. Martin, Gene R. Pesola, Stephen P. Peters, Christine A. Sorkness, Stanley J. Szefler, Elliot Israel
Journal: Journal of Allergy and Clinical Immunology (2005)
Chronic pericardial effusion after mediastinal radiotherapy.
Authors: S A Gomm, T B Stretton
Journal: Thorax (1981)

The pericardial complications which may follow mediastinal radiotherapy usually occur within five years of treatment.1 2 Acute pericarditis may occur early during treatment and chronic pericardial effusion or constrictive pericarditis may develop months or years later.A patient is reported who pre- sented with a chronic pericardial effusion 12 years after radiotherapy for stage IIA Hodgkin's disease. Case reportIn 1966, a 39-year old man, while working in the United States, received radiotherapy for Hodgkin's