tbuckley/cabot-search huggingface dataset:
Maintenance of Licensure
Authors: James J. Glazier
Journal: Annals of Internal Medicine (2013)

Letters5 February 2013Maintenance of LicensureJames J. Glazier, MDJames J. Glazier, MDFrom Oakland University William Beaumont School of Medicine, Rochester, Michigan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-3-201302050-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Chaudhry and colleagues (1) note the considerable similarity between the MOL process and the MOC process, which is required by members of the American Board of Medical Specialties, including the American Board of Internal Medicine (ABIM). I was particularly pleased to learn that the FSMB MOL Implementation Group has recently recommended that physicians actively engaged in the MOC program of the American Board of Medical Specialties or the American Osteopathic Association Bureau of Osteopathic Specialists be recognized as having fulfilled the requirements for MOL in any state. Indeed, if this recommendation is adopted, documentation of participation in ...References1. Chaudhry HJ, Talmage LA, Alguire PC, Cain FE, Waters S, Rhyne JA. Maintenance of licensure: supporting a physician's commitment to lifelong learning. Ann Intern Med. 2012;157:287-9. [PMID: 22733035] LinkGoogle Scholar2. Glazier JJ. Recertification for grandfathers [Letter]. Am J Med. 2011;124:11. [PMID: 21962321] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Oakland University William Beaumont School of Medicine, Rochester, Michigan.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMaintenance of Licensure: Supporting a Physician's Commitment to Lifelong Learning Humayun J. Chaudhry , Lance A. Talmage , Patrick C. Alguire , Frances E. Cain , Sandra Waters , and Janelle A. Rhyne Maintenance of Licensure Connie Nugent and Kenneth M. Nugent Maintenance of Licensure Humayun J. Chaudhry , Lance A. Talmage , and Janelle A. Rhyne Maintenance of Licensure Paul Kempen Maintenance of Licensure Marc S. Frager Metrics 5 February 2013Volume 158, Issue 3Page: 220KeywordsConflicts of interestPatients ePublished: 5 February 2013 Issue Published: 5 February 2013 CopyrightCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Effects of n-3 fish oil on metabolic and histological parameters in NASH: A double-blind, randomized, placebo-controlled trial
Authors: Curtis K. Argo, James T. Patrie, Carolin Lackner, Thomas D. Henry, Eduard E. de Lange, Arthur L. Weltman, Neeral L. Shah, Abdullah M. Al-Osaimi, Patcharin Pramoonjago, Saumya Jayakumar, Lukas P. Binder, Winsor D. Simmons-Egolf, Sandra G. Burks, Yongde Bao, Ann Gill Taylor, Jessica Rodriguez, Stephen H. Caldwell
Journal: Journal of Hepatology (2014)
Hypotension after Noradrenaline
Authors: H. G. Langford
Journal: BMJ (1959)

Special schools play a significant role in the daily lives of children and young people with special educational needs and disabilities. We explored the impact of the COVID-19-related first lockdown and resulting school closure by surveying parents whose children attended three special schools in Bedford, UK. We asked about anxiety and impact on emotional well-being and education. We received 53 responses from parents: 31 felt their child was more anxious during the lockdown period/school closure compared with beforehand and 42 felt their child’s emotional well-being had been affected. Children and young people attending special schools may have struggled both academically and emotionally during the COVID-19 pandemic.
Burden of influenza B virus infections in Scotland in 2012/13 and epidemiological investigations between 2000 and 2012
Authors: H Harvala, D Smith, K Salvatierra, R Gunson, B von Wissmann, A Reynolds, C Frew, A MacLean, A Hunt, D Yirrell, P Simmonds, J McMenamin, K Templeton
Journal: Eurosurveillance (2014)

We describe the burden of influenza B infections in Scotland during a 13-year study period. Influenza A and B viruses cocirculated throughout the period, with numbers of influenza B cases approaching or exceeding those of influenza A during six influenza seasons. Influenza B viruses of both Victoria and Yamagata lineage were detected in two of six seasons investigated. For the 2012/13 season, influenza B accounted for 44.4% of all influenzas, with the highest incidence in those under the age of five years. Influenza B virus infections led to fewer admissions to an intensive care unit (ICU) and a lower mortality rate than influenza A (37 vs 81 ICU admissions and three vs 29 deaths) during the 2012/13 season. However, a quarter of those admitted to ICU with influenza B had not been immunised and 60% had not received specific influenza antiviral therapy. This highlights the need for consistent influenza vaccination and prompt usage of antiviral treatment for identified risk groups. Combining the newly introduced vaccination programme for children with the use of a tetravalent vaccine may provide the opportunity to improve the control of influenza B in those with the highest influenza B burden, children and young adolescents.
STUDY OF FOUR HUNDRED AND EIGHTY-FIVE CASES WITH GENITAL LESIONS
Authors: JAMES RUSSELL DRIVER
Journal: JAMA (1922)

The conditions diagnosed in a study of 485 cases showing lesions of the genitalia clinically suspicious of venereal disease are presented in Table 1. This series constitutes all the material of this type seen in the skin and syphilis clinic of the outpatient department of Lakeside Hospital and in private practice by me and my associate, Dr. Harold N. Cole, from Aug. 1, 1920, to Feb. 1, 1922, a period of eighteen months. The methods employed in coming to a final diagnosis will be briefly outlined. <h3>HISTORY</h3> The history of the case is often helpful, if accurate data can be obtained. In chancroid, the incubation period is short, as a rule less than ten days; while in syphilis the incubation period is usually from ten days to six weeks. We have found the history to be the least reliable of all clinical aids, and it should not be the sole
An 80-Year-Old Man With Memory Loss, 1 Year Later
Authors: Tom Delbanco
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lessons learned from cancer may help in the treatment of pulmonary hypertension
Authors: S. Adnot
Journal: Journal of Clinical Investigation (2005)

Hyperplasia of pulmonary artery SMCs (PASMCs) is a pathological hallmark of pulmonary arterial hypertension (PAH). In this issue of the JCI, McMurtry et al. report that adenovirus-mediated overexpression of survivin--a multipotent inhibitor of apoptosis--induces PAH in rats, whereas inhalation of an adenovirus vector encoding a mutant survivin gene with dominant-negative properties reverses established monocrotaline-induced PAH. These findings raise important issues regarding the role of survivin in the pathogenesis of PAH, its value as a prognostic indicator, and its use as a target for new therapeutic strategies.
A Twin Study of Genetic Relationships Between Psychotic Symptoms
Authors: Alastair G. Cardno, Frühling V. Rijsdijk, Pak C. Sham, Robin M. Murray, Peter McGuffin
Journal: American Journal of Psychiatry (2002)

OBJECTIVE: Biometrical model fitting was applied to clinical data from twins to investigate whether operationally defined schizophrenic, schizoaffective, and manic syndromes share genetic risk factors. METHOD: Seventy-seven monozygotic and 89 same-sex dizygotic twin pairs in which the proband met the Research Diagnostic Criteria (RDC) for lifetime-ever schizophrenic, schizoaffective, or manic syndrome were ascertained from the Maudsley Twin Register in London. The syndromes were defined nonhierarchically. Correlations in liability were calculated for each syndrome in the monozygotic and dizygotic pairs and across the three pairings of schizophrenic-manic, schizophrenic-schizoaffective, and schizoaffective-manic syndromes both within probands and within pairs. For the three syndromes considered together, an independent pathway model was fitted. RESULTS: The model fitting showed significant genetic correlations between all three syndromes. There was evidence of both common and syndrome-specific genetic contributions to the variance in liability to the schizophrenic and manic syndromes, but the genetic liability to the schizoaffective syndrome was entirely shared in common with the other two syndromes. In contrast, environmental liability to the schizoaffective syndrome was not shared with the other syndromes. CONCLUSIONS: If diagnostic hierarchies are relaxed, there is a degree of overlap in the genes contributing to RDC schizophrenic, schizoaffective, and manic syndromes. Supplementing the traditional approach of assigning a single main lifetime diagnosis with information on within-person comorbidity of psychotic syndromes may provide valuable information about the familial aggregation of psychotic symptoms.
Blair launches radical NHS plan for England
Authors: Linda Beecham
Journal: BMJ (2000)

Prime Minister Tony Blair has launched a reform programme for the NHS in England that he believes will once again make it “the healthcare system the world most envies.”

The NHS Plan: A plan for Investment, a Plan for Reform proposes changes to consultants' and GPs' contracts; promises more doctors and nurses; sets targets for waiting times for treatment; recommends a concordat between the NHS and the private sector; and aims to reduce inequalities.

Tony Blair criticised consultants' and GPs' contracts, which he said were “outdated and inflexible.”

The government has ruled out “buying out” consultants in private practice, which it estimated would cost at least £700m ($1050m). Instead, newly qualified consultants will be contracted to work exclusively for the NHS for “perhaps the first seven years” of their career, providing eight fixed sessions and more of the out of hours service.

The right to undertake private practice will depend on fulfilling job plans and NHS service requirements. If agreement cannot be reached on these changes the government says that it will consider introducing a new specialist grade for newly qualified hospital specialists. In addition, all existing consultants will have to work seven fixed sessions a week.

Distinction awards and discretionary points, which provide £170m a year in superannuable bonus payments for senior doctors, will be merged into a single, …
Human Goodpasture anti-α3(IV)NC1 autoantibodies share structural determinants Rapid Communication
Authors: Kevin E.C. Meyers, Paul A. Kinniry, Raghuram Kalluri, Eric G. Neilson, Michael P. Madaio
Journal: Kidney International (1998)

To examine the structural relationship among autoantibodies produced by individuals with anti-GBM antibody-mediated disease, a polyclonal anti-idiotype directed against human anti-alpha3(IV)NC1 antibodies was produced and then used to study autoantibodies from other patients. For this purpose, anti-alpha3(IV)NC1 antibodies (anti-GBM), derived from a single patient (LL) with high titer and typical anti-GBM antibody specificity, were isolated using recombinant alpha3(IV)NC1-sepharose affinity chromatography. Following hyperimmunization of rabbits with anti-GBM IgG, irrelevant rabbit anti-human IgG antibodies were removed from the antiserum using a human IgG-sepharose column. The rabbit anti-alpha3(IV)NC1 antibodies (anti-Id GBM) effluent bound to human anti-GBM antibodies, but it did not bind to either normal human IgG or recombinant alpha3(IV)NC1 protein. The Id-anti-Id interaction was conformationally dependent on intact heavy and light chains of the anti-alpha3(IV)NC1 antibodies (ELISA and Western blotting). A competitive immunoassay was developed to evaluate structural and potential genetic relationships among anti-alpha3(IV)NC1 antibodies from different patients. All patients tested (9 of 9) had a substantial fraction (producing > 50% inhibition) of anti-GBM antibodies expressing Id-GBM. The results indicate that shared determinants are expressed by anti-GBM antibodies from different individuals, and they raise the possibility that common genetic elements are used to encode them. These regions are potential targets for design of reagents to regulate autoreactive B cells and/or interfere with pathogenic antibody-GBM interactions, in individuals with anti-GBM antibody mediated diseases.
Efficient intracellular delivery and multiple-target gene silencing triggered by tripodal RNA based nanoparticles: A promising approach in liver-specific RNAi delivery
Authors: S. Sajeesh, Tae Yeon Lee, Joon Ki Kim, Da Seul Son, Sun Woo Hong, Soohyun Kim, Wan Soo Yun, Soyoun Kim, Chanil Chang, Chiang Li, Dong-ki Lee
Journal: Journal of Controlled Release (2014)
Infarction of the Midgut Associated with Oral Contraceptives
Authors: Murray F. Brennan, Alan M. Clarke, William A. A. G. Macbeth
Journal: New England Journal of Medicine (1968)

2 cases of midgut infarction in patients taking oral contraceptives are reported. Case 1 was a 38-year-old married woman with 3 children. After 2 isolated bouts of severe abdominal pain and diarrhea, examination revealed only minimal epigastric and left loin tenderness. Blood counts were normal. Other tests were negative. She had been taking cyclical tablets of 2.5 mg norethynodrel and .1 mg mestranol (Con ovid-E) for 48 months and continued after 8 days in the hospital. 18 weeks later severe abdominal pain, vomiting, and diarrhea occurred with abdominal tenderness and rigidity. The white-cell count was 25,000 with 85-90% segmented forms. Other blood tests were normal. At operation the superior mesenteric artery was found to be occluded distal to the origin of the middle colic artery. The thrombus was removed and the circulation to the gut seemed adequate. Intravenous heparin was given. Reoperation at 12 and again at 36 hours revealed viable intestine. 8 days after hospital admission ileus symptoms occurred. Reoperation revealed gangrene of almost all of the small intestine and part of the large intestine. The patient died 3 days later. Autopsy showed thrombosis of the superior mesenteric artery which was apparently not associated with local atheroma. Minimal atheroma in the aorta and an infarct of the spleen were noted. Case 2 was a 45-year-old married woman with 2 children who complained of severe abdominal pain and vomiting of 8 hours duration. A similar attack 1 week earlier had subsided in 6 hours. She had been taking tablets of 5 mg ethinyl-esternol (lynestrenol) and .15 mg mestranol (Noracyclin) for 11 months. There was no fever. The white-cell count was 19,500 with 85% segmented forms. Other laboratory tests and X-ray were normal. A loud bruit was heard over the upper abdomen. Bowel sounds were hyperactive. A diagnosis of acute small-bowel obstruction was made. At operation a definite diagnosis could not be made. Symptoms became worse. Reoperation 10 days later revealed gangrenous small intestine and part of the large intestine. The gangrenous parts were removed. After a complicated convalescence the patient recovered, but has moderate steatorrhea. Histologic examination of the resected intestine showed no evidence of atheroma in the mesenteric vessels. Considering these 2 cases with premonitory warning symptoms and without evidence of an atheromatous cause but associated with oral contraceptive therapy the immediate discontinuance of such therapy in women who develop acute abdominal pain is irecommended.
TennCare and Academic Medical Centers
Authors: Gregg S. Meyer
Journal: JAMA (1996)

<h3>Objective.</h3> —To ascertain the potential impact of public-sector—driven health system reform (Medicaid and Medicare programs) on academic medical centers (AMCs). <h3>Design.</h3> —A qualitative, case-study investigation of how 2 of Tennessee's 4 AMCs were affected by the TennCare program, which enrolled all of the state's Medicaid recipients and a sizable portion of its uninsured in managed care organizations (MCOs) in January 1994. <h3>Methods.</h3> —We reviewed pertinent documents related to the AMCs' response to TennCare; interviewed AMC executives and staff, state officials, and representatives of MCOs serving TennCare beneficiaries; and conducted site visits at both AMCs. <h3>Main Outcome Measures.</h3> —Changes in clinical revenues, clinical volume, patient selection, support for the AMCs' teaching and research missions, and the AMCs' response to these changes. <h3>Results.</h3> —Both AMCs studied experienced large revenue shortfalls, the closure of some specialty services, adverse patient selection, and loss of the patient volume needed to do clinical research, and had to reduce the number of training program positions. Longer-term consequences of TennCare for AMCs may include the integration of community-based services into academic missions, the acceleration of clinical diversification, and the attainment of experience in managed care, anticipating the evolution of the private-sector market. <h3>Conclusions.</h3> —The consequences of public-sector health system reform for AMCs are similar to, and equally as challenging as, the effects of private-sector changes in health care delivery. Important differences include the rapidity with which public-sector reforms can transform the AMC market, the vulnerability of special payments to AMCs, such as graduate medical education funding, and the accountability of managers of public-sector initiatives to the political process. It remains to be seen whether public-sector reforms will afford some competitive advantage to AMCs over the long term.
Obesity, Fat Metabolism and Cardiovascular Disease
Authors: JOHN W. GOFMAN, HARDIN B. JONES
Journal: Circulation (1952)

Lipoproteins of the S f 12-100 class, representing only about 10 to 15 per cent of the serum cholesterol, are strongly associated with atherosclerosis. The major independent contributions to this association are from the S f 12-20 lipoproteins and the S f 35-100 lipoproteins. The S f 20-35 lipoproteins are primarily associated by virtue of their intercorrelation with the other classes. Obesity is moderately associated with the S f 35-100 and definitely, but to a lesser degree, with the S f 12-20. The association of obesity with total serum cholesterol is so low as to obscure the stronger association with the S f 35-100 lipoproteins. The relationship of the S f 12-100 lipoproteins with obesity may be adequate to explain the major share, if not all, of the association of obesity with atherosclerosis. The control of obesity should therefore be a prime consideration in the management of atherosclerosis and its complications.
371. Optimizing Custom Zinc-Finger Nucleases for Use in Human Cells
Authors: Stephen Alwin, Maja B. Gere, Eva Guhl, Karin Effertz, Carlos F. Barbas, David J. Segal, Matthew D. Weitzman, Toni Cathomen
Journal: Molecular Therapy (2005)

Genome engineering is a powerful instrument to study basic biological questions or to create treatment options for genetic diseases. A safe way to correct genetic mutations is through homologous recombination (HR), during which a mutant sequence is replaced with the corresponding wild-type sequence. While HR is predominant in yeast, it is a rare event in mammalian cells where non-homologous recombination is much more frequent. The creation of a targeted DNA double-strand break (DSB) has been shown to locally stimulate HR several hundred-fold by activating the cellular machinery for double-strand break repair, but it presupposes the availability of a site-specific endonuclease to create the DSB. Some initial experiments with artificial nucleases in human cells revealed that cytotoxicity of such enzymes is a major issue, most likely through cleavage at non-specific sites. Here, we present a rapid two-step method to evaluate and optimize novel, rationally designed endonucleases. In a first step, the DNA-binding domain was synthesized by assembling predefined C2H2-zinc-finger modules and fused to a transcriptional activation domain. Each zinc-finger module is designed to recognize 3 bp of DNA and the modules can be assembled in any order necessary to recognize any given sequence in a target locus. DNA-binding specificity of these artificial transcription factors was assessed in a reporter assay. In a second step, the DNA-binding domain was attached to the catalytic domain of the FokI restriction endonuclease to generate the custom nucleases. Upon co-transfection with a repair matrix, they were assessed for their ability to stimulate HR in an episomal gene repair assay. We have engineered several kinds of custom nucleases and demonstrate that high specificity, fine-tuned expression kinetics and protein design are absolutely critical to promote HR. Importantly, the same parameters are also crucial for a low level of cytotoxicity. After optimization, expression of the custom nucleases stimulated both episomal and chromosomal gene repair and HR was achieved in 35% or 2.5% of transfected cells, respectively. Thus, custom nucleases will be a valuable tool to stimulate gene repair for therapeutic purposes. Moreover, they can be easily combined with viral vector systems for efficient delivery.
The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling
Authors: Hua Tang, Weiping Cao, Sudhir Pai Kasturi, Rajesh Ravindran, Helder I Nakaya, Kousik Kundu, Niren Murthy, Thomas B Kepler, Bernard Malissen, Bali Pulendran
Journal: Nature Immunology (2010)
The gamete fusion process is defective in eggs of Cd9-deficient mice
Authors: Keisuke Kaji, Shoji Oda, Tomohide Shikano, Tatsuya Ohnuki, Yoshikatsu Uematsu, Junko Sakagami, Norihiro Tada, Shunichi Miyazaki, Akira Kudo
Journal: Nature Genetics (2000)
Acetone Tests in Diabetic Coma
Authors: K. J. Gurling, H. R. Millar
Journal: BMJ (1954)

CORRESPONDENCEartery and recognized the fact before I had the misfortune to do so without eliciting the usual signs of this mishap.Almost 2 ml.containing 0.1 g. of thiopentone was injected before pain drew attention to mv error.This was followed by blanching and then coldness of the affected limb segment.I shall continue to believe that I exercised " reasonable" skill and care and that intra-arterial injection of thiopentone cannot be entirely avoided.-I am, etc.,