Screening for Lung Cancer With Low-Dose Computed Tomography
Authors: John Brodersen, Jakob Fraes Rasmussen, Bruno Heleno
Journal: Annals of Internal Medicine (2014)

Letters4 February 2014Screening for Lung Cancer With Low-Dose Computed TomographyJohn Brodersen, MD, GP, PhD, Jakob Fraes Rasmussen, MD, and Bruno Heleno, MD, GPJohn Brodersen, MD, GP, PhDFrom University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this author, Jakob Fraes Rasmussen, MDFrom University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this author, and Bruno Heleno, MD, GPFrom University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Humphrey and colleagues (1) recommend annual screening for lung cancer with low-dose computed tomography (LDCT) in persons at high risk for lung cancer based on age and smoking history. Given the lack of evidence about overdiagnosis, psychosocial consequences, and cost-effectiveness of this screening, we cannot understand how there is “high certainty that the net benefit is moderate or there is moderate certainty that the net benefit is moderate to substantial” (2).There is considerable uncertainty about the extent of overdiagnosis with LDCT screening. We think that plausible estimates can be obtained from the NLST (National Lung Screening ...References1. Humphrey LL, Deffebach M, Pappas M, Baumann C, Artis K, Mitchell JP, et al. Screening for lung cancer with low-dose computed tomography: a systematic review to update the U.S. Preventive Services Task Force recommendation. Ann Intern Med. 2013;159:411-20. [PMID: 23897166] LinkGoogle Scholar2. Moyer VA; U.S. Preventive Services Task Force. Screening for Lung Cancer: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med. 2013;:. [PMID: 24378917] MedlineGoogle Scholar3. Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al; National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365:395-409. [PMID: 21714641] CrossrefMedlineGoogle Scholar4. Oken MM, Hocking WG, Kvale PA, Andriole GL, Buys SS, Church TR, et al; PLCO Project Team. Screening by chest radiograph and lung cancer mortality: the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized trial. JAMA. 2011;306:1865-73. [PMID: 22031728] CrossrefMedlineGoogle Scholar5. Marcus PM, Bergstralh EJ, Fagerstrom RM, Williams DE, Fontana R, Taylor WF, et al. Lung cancer mortality in the Mayo Lung Project: impact of extended follow-up. J Natl Cancer Inst. 2000;92:1308-16. [PMID: 10944552] CrossrefMedlineGoogle Scholar6. Brodersen J, Thorsen H, Kreiner S. Consequences of screening in lung cancer: development and dimensionality of a questionnaire. Value Health. 2010;13:601-12. [PMID: 20345552] CrossrefMedlineGoogle Scholar7. Aggestrup LM, Hestbech MS, Siersma V, Pedersen JH, Brodersen J. Psychosocial consequences of allocation to lung cancer screening: a randomised controlled trial. BMJ Open. 2012;2:000663. [PMID: 22382119] CrossrefMedlineGoogle Scholar8. Hestbech MS, Siersma V, Dirksen A, Pedersen JH, Brodersen J. Participation bias in a randomised trial of screening for lung cancer. Lung Cancer. 2011;73:325-31. [PMID: 21324544] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: John Brodersen, MD, GP, PhD; Jakob Fraes Rasmussen, MD; Bruno Heleno, MD, GPAffiliations: From University of Copenhagen, Copenhagen, DenmarkDisclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L13-1112. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Lung Cancer With Low-Dose Computed Tomography: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation Linda L. Humphrey , Mark Deffebach , Miranda Pappas , Christina Baumann , Kathryn Artis , Jennifer Priest Mitchell , Bernadette Zakher , Rongwei Fu , and Christopher G. Slatore Screening for Lung Cancer With Low-Dose Computed Tomography John Brodersen , Asger Dirksen , and Jesper Holst Pedersen Screening for Lung Cancer With Low-Dose Computed Tomography Linda L. Humphrey , Mark Deffebach , Miranda Pappas , Bernadette Zakher , and Christopher G. Slatore Metrics Cited byImpact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality 4 February 2014Volume 160, Issue 3Page: 211KeywordsCancer screeningComputed axial tomographyDiagnostic radiologyLung and intrathoracic tumorsLung cancer screeningOvarian cancer screeningPsychometricsQualitative studiesQuestionnairesThorax ePublished: 4 February 2014 Issue Published: 4 February 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...