Hypokalemia in Leukemia
Authors: JOEL S. GREENBERGER
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 June 1975Hypokalemia in LeukemiaJOEL S. GREENBERGER, M.D., DAVID S. ROSENTHAL, M.D., WILLIAM C. MOLONEY, M.D.JOEL S. GREENBERGER, M.D.Search for more papers by this author, DAVID S. ROSENTHAL, M.D.Search for more papers by this author, WILLIAM C. MOLONEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-854 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent paper, Mir and associates (Ann Intern Med 82:54-57, 1975) propose that the hypokalemia that often occurs in association with acute myeloid leukemia may be unrelated to levels of serum or urine lysozyme. We wish to comment on their data and draw their attention to some work in an appropriate animal model.In a study of 32 patients, the authors reported that of 18 patients with elevated serum lysozyme levels, only 9 became hypokalemic. Similarly, of 18 patients with elevated levels of urinary lysozyme, only 10 became hypokalemic. The reverse correlation showed that although 19...References1. ROSENTHAL D, MAGLIO R, and MOLONEY W: Muramidasuria and hyperkaluria in the chloroleukemic rat. Proc Soc Exp Biol Med 141:499-500, 1972 CrossrefMedlineGoogle Scholar2. GREENBERGER J, ROSENTHAL D, and MOLONEY W: Studies on hypermuramidasemia in the normal and chloroleukemic rat, the role of the kidney. J Lab Clin Med 81:116-121, 1973 MedlineGoogle Scholar3. SKARIN A, MATSUO Y, and MOLONEY W: Muramidase in myeloproliferative disorders terminating in acute leukemia. Cancer 29:1336-1342, 1972 CrossrefMedlineGoogle Scholar4. MUGGIA F, HEINEMANN H, and FARHANGI M: Lysozymuria and renal tubular dysfunction in monocytic and myelomonocytic leukemia. Am J Med 47:351-365, 1969 CrossrefMedlineGoogle Scholar1. KLASTERSKY J, VANDERKELEN B, and DANEAU D: Carbenicillin and hypokalemia (letter). Ann Intern Med 78:774-775, 1973 LinkGoogle Scholar2. TATTERSALL M, BATTERSBY G, and SPIERS A: Antibiotics and hypokalaemia (letter). Lancet 1:630-631, 1972 CrossrefMedlineGoogle Scholar3. MUGGIA F, HEINEMANN H, and FARHANGI M: Lysozymuria and renal tubular dysfunction in monocytic and myelomonocytic leukemia. Am J Med 47:351-366, 1969 CrossrefMedlineGoogle Scholar4. PICKERING T and CATOVSKY D: Hypokalaemia and raised lysozyme levels in acute myeloid leukaemia. Q J Med 42:677-682, 1973 MedlineGoogle Scholar1. MIR M and DELAMORE I: Hypouricaemia and proximal renal tubular dysfunction in acute myeloid leukaemia. Br Med J 3:775-777, 1974 CrossrefMedlineGoogle Scholar2. MIR M and BOBINSKI H: Altered membrane sodium transport and the presence of a plasma ouabain-like inhibitory factor in acute myeloid luekaemia. Clin Sci Mol Med 48:213-218, 1975 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOEL S. GREENBERGER, M.D.; DAVID S. ROSENTHAL, M.D.; WILLIAM C. MOLONEY, M.D.Affiliations: Division of Hematology Department of Medicine Peter Bent Brigham Hospital Boston, Massachusetts 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by1,3,4-Oxadiazines and 1,3,4-ThiadiazinesNeoplasms and the KidneySpurious Hypokalemia in Myeloproliferative DisordersMetabolic Disorders in Acute Myeloid LeukaemiaKomplikationen und supportive Therapie der Leukämien und malignen Non-Hodgkin-LymphomeCellular Proliferation and HypokalemiaFRED J. SCHIFFMAN, M.D., ROBERT L. SCHIFFMAN, M.D., ROBERT M. ROSA, M.D.Gastrointestinale Komplikationen akuter LeukämienChronic Granulocytic Leukemia: Hypokalemia in Acute Blastic CrisisKAI-YIU YEUNG, M.D., F.A.C.P., ARTHUR A. TROWBRIDGE, M.D. 1 June 1975Volume 82, Issue 6Page: 854-855KeywordsAcute myeloid leukemiaAnimal modelsLysozymeUrine ePublished: 1 December 2008 Issue Published: 1 June 1975 PDF downloadLoading ...