tbuckley/cabot-search huggingface dataset:
Dropsy following Scarlet Fever
Authors: S. S. Alison
Journal: BMJ (1849)

THE object which the author of this paper has in view, is to contribute to the natural history of an interesting, and sometimes irremediable disease, viz., the Dropsy' following Scarlet Fever; and to indicate the most suitable treatment, both for the cure and the prevention of this affection.Its natural history will be illustrated by an historical expo- sition of the antecedent, concomitant, and subsequent circumstances, of twelve cases carefully observed.form of Watery effusion inito the cellular tissue, anf shlut sacs of the body.The Words Auasrca and (Edema are used in their strictly limited sense.
Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting
Authors: Sonia D'Souza, Hironobu Murata, Moncy V. Jose, Sholpan Askarova, Yuliya Yantsen, Jill D. Andersen, Collin D.J. Edington, William P. Clafshenkel, Richard R. Koepsel, Alan J. Russell
Journal: Biomaterials (2014)
Correlation of Platelet Calcium with Blood Pressure
Authors: Paul Erne, Peter Bolli, Ernst Bürgisser, Fritz R. Bühler
Journal: New England Journal of Medicine (1984)

Intracellular free calcium has been implicated in vascular smooth-muscle contraction and in the pathophysiology of essential hypertension. We studied free-calcium levels in blood platelets, which have many features in common with vascular smooth-muscle cells. With use of an intracellularly trapped fluorescent dye, the free-calcium concentration in platelets was found to be elevated in 9 patients with borderline hypertension and 45 patients with established essential hypertension, who were compared with 38 normotensive subjects. There was a close correlation between the free-calcium level and both systolic and diastolic blood pressure (n = 92; r = 0.883 for systolic pressure and 0.931 for diastolic pressure; P<0.001 for both). Antihypertensive treatment with calcium-entry blockers (n = 15), beta-adrenoceptor blockers (n = 12), or a diuretic (n = 6) resulted in a reduction in free calcium, and this correlated with the fall in blood pressure (P<0.001). The intracellular free-calcium concentration in platelets may be determined by the same humoral or pharmacologic factors that determine the height of blood pressure. (N Engl J Med 1984; 310:1084–8.)
Interferon- responses to Mycobacterium tuberculosis-specific antigens in diabetes mellitus
Authors: Suay-Hong Gan, Kyi-Win KhinMar, Timothy M Barkham, Chwee-Kim Koh, Liang Shen, Yee-Tang Wang, Cynthia B E Chee
Journal: European Respiratory Journal (2014)

To the Editor: 

Although diabetes mellitus has long been recognised as a risk factor for tuberculosis, it was only recently that strong evidence for this emerged [1]. Persons with diabetes mellitus have a two or three times higher risk of developing tuberculosis disease than nondiabetics; those with tuberculosis and diabetes mellitus have a four times higher risk of death during tuberculosis treatment and a higher risk of tuberculosis relapse [2, 3].

Diabetics therefore constitute a target group in whom the identification of latent tuberculosis infection (LTBI) and its treatment may potentially be an important strategy for tuberculosis elimination [4, 5]. Interferon-γ release assays (IGRAs) are immunodiagnostic tests for identification of LTBI. These tests have shown superior specificity and positive predictive value for progression to active disease over the tuberculin skin test [6–9]. Although the IGRAs do not distinguish active from latent tuberculosis [10, 11], they are often done as part of the work-up for active tuberculosis in cases where diagnostic uncertainty exists. To date, there is scant information in the literature regarding the performance of these assays in diabetics.

In a previous report in which we evaluated the T-SPOT. TB (Oxford Immunotec, Abingdon, UK) and QuantiFERON In-Tube (QFT-IT) (Cellestis, Melbourne, Australia) assays in a head-to-head manner in 270 culture-confirmed pulmonary tuberculosis patients, we had found undiminished sensitivity of these assays in the presence of diabetes mellitus [12]. Walsh et al. [13] have also reported that diabetes did not affect the performance of the second-generation QuantiFERON TB Gold (QFT-G) and T-SPOT. TB …
Promoting health and improving survival into very old age
Authors: M. M. Glymour, T. L. Osypuk
Journal: BMJ (2012)

Further research needed to establish the ideal timing and content of interventions

The identification of strategies that can promote health and productivity into old age is one of the most important challenges facing public health.1 In a linked research paper (doi:10.1136/bmj.e5568), Rizzuto and colleagues present welcome evidence that can help inform such strategies.2 The authors found that several modifiable factors—including smoking, being part of a social network, and participating in leisure time activities—predicted survival in respondents in a cohort of more than 1800 people aged 75 years or over from the Swedish town of Kungsholmen. The estimated effects were large. Participation in leisure activities categorised as “productive,” “social,” or “physical” predicted 0.9-1.4 additional years of survival. These results are largely consistent with findings in other populations,3 4 5 6 which suggests that the associations are generalisable beyond the current study’s population. How can these findings be interpreted and what do they mean in terms of real health benefits? There are clinical and policy responses that are potentially justified by the current evidence base. However, acknowledging the study’s limitations will help to identify the crucial next steps in this research agenda.

The greatest challenge is to …
Prevalence of Metabolic Syndrome Among HIV Patients
Authors: Carmine Gazzaruso, Paolo Sacchi, Adriana Garzaniti, Pietro Fratino, Raffaele Bruno, Gaetano Filice
Journal: Diabetes Care (2002)

Recently published observations (1) suggest that among HIV-positive patients treated with highly active antiretroviral therapy (HAART), the incidence of cardiovascular diseases is increased. Until now, no specific risk factors have been identified except for those related to behavior or metabolic abnormalities. So far, a sum of metabolic abnormalities have frequently been reported among these patients, including increased lipid levels, abnormal fat distribution, elevated blood pressure, and disturbance in glucose metabolism (2). Studies designed to identify subclinical atherosclerosis in HIV-infected patients on HAART have been inconclusive. Numerous modalities, including carotid intimal thickness measurement, brachial reactivity, and electron beam computed tomography, have shown varying results; at this time, it is unclear what the results mean. The metabolic syndrome is a cluster of risk factors (disturbance …
Response to exercise in patients after total surgical correction of Tetralogy of Fallot.
Authors: F W James, S Kaplan, D C Schwartz, T C Chou, M J Sandker, V Naylor
Journal: Circulation (1976)

Heart rate, blood pressure, physical working capacity, and electrocardiographic changes were evaluated during upright bicycle exercise in 43 asymptomatic patients, aged seven to 41 years, one to 14 years after total surgical correction of tetralogy of Fallot (TF). One hundred and nine normal subjects between the ages of five and 42 years served as controls. The patient and control groups, subdivided by sex and body surface area (BSA), were similar in height and weight. When comparing males to males and females to females with BSA greater than or equal to 1.2 m2, maximal heart rates and working capacities were lower in the patient groups than in the control groups. An inverse relationship was observed between maximal working capacity and age at surgery in both male and female patient groups. By contrast, especially in the males with BSA less than 1.2 m2, the mean maximal heart rates and working capacities did not differ significantly between the patient and control groups. Premature atrial or ventricular contractions were recorded in ten of 43 patients (23%) after exercise. Five of these ten patients had multifocal premature ventricular contractions (PVC) and four had unifocal PVC. In the five patients with multifocal PVC, a short burst of ventricular tachycardia occurred in two, coupling in one, and bigeminal rhythm in two. Cardiac arrhythmia was not observed in the control group. Although our current surgical results are excellent, this study suggests that impaired cardiovascular function persists after corrective surgery and that early surgical treatment may be more desirable. Furthermore, additional data suggest that the exercise procedure may be useful in detecting and managing patients who may develop life-threatening arrhythmias following intraventricular surgery.
New Cancer Statistics Show Losses, Gains
Authors: M. E. Newman
Journal: JNCI Journal of the National Cancer Institute (1990)

New Cancer Statistics Show Losses, Gains Get access Michael E. Newman Michael E. Newman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 15, 1 August 1990, Pages 1238–1240, https://doi.org/10.1093/jnci/82.15.1238 Published: 01 August 1990
Monitoring treatment with aminoglycoside antibiotics.
Authors: W R Gransden, S J Eykyn
Journal: BMJ (1993)

Phaeochromocytoma of the spermatic cord is very rare. It can arise anywhere in the distribution of cells of neural crest origin, but 80-90% arise in the adrenal medulla and only 3% are extra-abdominal. A small tumour may be asymptomatic because insufficient catecholamines are secreted to cause haemodynamic disturbance.
Splitting of Second Heart Sound at Mitral Area Without Pulmonary Hypertension
Authors: DENNIS J. BAUMAN
Journal: Annals of Internal Medicine (1974)

Letters1 June 1974Splitting of Second Heart Sound at Mitral Area Without Pulmonary HypertensionDENNIS J. BAUMAN, M.D., RICHARD B. SUTTON, M.D., THEOFILOS J. TSAGARIS, M.D.DENNIS J. BAUMAN, M.D.Search for more papers by this author, RICHARD B. SUTTON, M.D.Search for more papers by this author, THEOFILOS J. TSAGARIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-6-771_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Inspiratory splitting of the second heart sound (S2) in normal adults is generally thought to be audible only at the pulmonic area and along the left sternal border (1, 2). Splitting at the mitral area is considered a reliable sign of pulmonary hypertension (1-5). We have recently studied four patients with normal resting pulmonary artery pressure, in whom both components of S2were easily heard at the mitral area during inspiration. The patients were referred for study because of chest pain, and coronary arteriography showed significant obstructing lesions in all cases. All were clinically stable at the...References1. LEATHAM A: Auscultation of the heart. Lancet 2:703-708, 1958 CrossrefMedlineGoogle Scholar2. FRIEDBERG C: Diseases of the Heart, 3rd ed. Philadelphia, W. B. Saunders Co., 1966, p. 77 Google Scholar3. HARRIS A: The second heart sound in health and in pulmonary hypertension. Am Heart J 79:145-148, 1970 CrossrefMedlineGoogle Scholar4. LEATHAM A: The first and second heart sounds, in The Heart, 2nd ed., edited by HURST JW, LOGUE RB. New York, McGraw-Hill Book Co., 1970, p. 252 Google Scholar5. LUISADA A: Auscultation and phonocardiography, in Examination of the Cardiac Patient, edited by LUISADA AA. New York, McGraw-Hill Book Co., 1965, p. 108 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DENNIS J. BAUMAN, M.D.; RICHARD B. SUTTON, M.D.; THEOFILOS J. TSAGARIS, M.D.Affiliations: Salt Lake Veterans Administration Hospital Department of Medicine University of Utah College of Medicine Salt Lake City, Utah 84132 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1974Volume 80, Issue 6Page: 771-772KeywordsAngiographyHeartIschemiaLesionsPulmonary arteriesPulmonary hypertensionStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 June 1974 PDF downloadLoading ...
A Global Approach to Energy Metabolism in an Experimental Model of Sepsis
Authors: ERWAN L'HER, PHILIPPE SEBERT
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Disturbances in energy metabolism during sepsis are not clearly understood. The aim of the study was to globally assess the energy drive in septic rat myocytes, studying both glycolysis rates and mitochondrial maximal activities together, using recent in vitro techniques. Measurements were assessed before (H0) and 4 h after sepsis induction (H4). Hyperlactatemia was observed in all septic animals ([lactate] = 1.2 +/- 0.3 mmol/L at H0 versus 3.3 +/- 0.6 mmol/L at H4; p < 0.001). An enhanced glycolysis rate was observed in both aerobic ( J(A) = 7.2 +/- 0.9 at H0 versus 18.2 +/- 4.1 nmol glucose/min/g at H4; p < 0.05) and anaerobic ( J(B) = 7.5 +/- 1.2 at H0 versus 15.4 +/- 3.4 micromol glucose/min/g at H4; p < 0.05) fluxes, associated with a selective significant pyruvate-malate-dependent oxygen consumption rate decrease (V O(2)-PM = 0.144 +/- 0.008 at H0 versus 0.113 +/- 0.007 micromol O(2)/h/mg at H4; p < 0.05). This oxygen consumption decrease can be interpreted either as a complex I and/or a complex I-ubiquinone relation alteration. Our results are consistent with the hypothesis that an altered mitochondrial function during sepsis is responsible, at least in part, for hyperlactatemia, which is thus a consequence of an increased glycolysis rate.
Catalytic cleavage activities of 10–23 DNAzyme analogs functionalized with an amino group in its catalytic core
Authors: Qi Wang, Di Zhang, Maosheng Cheng, Junlin He, Keliang Liu
Journal: Acta Pharmaceutica Sinica B (2012)

Functionalization of the catalytic loop of 10–23 DNAzyme with an amino group was performed by incorporation of 7-(3-aminopropyl)-8-aza-7-deaza-2′-deoxyadenosine in different single positions. Among the nine modified positions in the catalytic loop, A9 is the unique position with positive contribution by such modification. These results indicated that more efficient deoxyribozymes remain to be explored by introduction of exogenous functional groups in an appropriate position in the catalytic loop of 10–23 DNAzyme, such as the combination of 7-functional group substituted 8-aza-7-deaza-2′-deoxyadenosine analogs and A9 position.
408 Prevalence of dust mites in the homes of asthmatics in several U.S. Geographical regions
Authors: M. Allen, L. Arlian, L. Bernstein, S. Friedman, A. Grant, P. Lieberman, M. Lopez, J. Metzger, M. Schatz, S. Spector, S. Wasserman
Journal: Journal of Allergy and Clinical Immunology (1988)
Relation Between the SYNTAX Score and Culprit Vessel Vulnerability in Non–ST-Segment Elevation Acute Coronary Syndrome
Authors: Kenichiro Saka, Kiyoshi Hibi, Ken Kozuma, Nobuhiko Maejima, Kozo Okada, Yasushi Matsuzawa, Mitsuaki Endo, Noriaki Iwahashi, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura
Journal: JACC. Cardiovascular imaging (2014)
Chronic Hypersensitivity Pneumonitis With Heart Involvement Observed During In-111 DTPA Octreotide (OctreoScan®) Imaging
Authors: Adonios Zanglis, Demetrios Andreopoulos, Athanassios Zissimopoulos, Nikolaos Baziotis
Journal: Clinical Nuclear Medicine (2003)

An 80-year-old farmer with unresectable hepatocellular carcinoma was referred to the authors’ department for evaluation of the somatostatin receptor status of his tumor. After intravenous administration of In-111 gadolinium–diethylenetriame pentaacetic acid (DTPA) octreotide (OctreoScan®, 5 mCi), the patient was imaged 24 hours and 48 hours later. Besides the presence of somatostatin receptors in his primary tumor and 1 intraabdominal metastatic site, diffuse pulmonary and heart uptake was observed. A review of the patient's history revealed that he had pulmonary fibrosis, resulting from hypersensitivity pneumonitis, secondary to his occupational exposure to chicken-derived antigens. The activated lymphocytic pulmonary and heart infiltration is the most likely explanation for the observed In-111 DTPA octreotide uptake.
Naloxone and Septic Shock
Authors: GEORGE S. HUGHES
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 April 1983Naloxone and Septic ShockGEORGE S. HUGHES JR., M.D., R. STEPHEN PORTER, PHARM.D., RICHARD MARX, M.D., CHRIS C. HARKERGEORGE S. HUGHES JR., M.D.Search for more papers by this author, R. STEPHEN PORTER, PHARM.D.Search for more papers by this author, RICHARD MARX, M.D.Search for more papers by this author, CHRIS C. HARKERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-4-559_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the report by Higgins and associates (1) on the reversal of hypotension by continuous infusion of naloxone in a ventilator-dependent patient. We report our experience with continuous infusion of naloxone in a larger group of eight patients with a documented cause of hypotension.All patients had underlying malignancies and met the following criteria for the diagnosis of spetic shock: hypotension (systolic blood pressure, 77. 8mm Hg ± 2.4 SE); oliguria ( < 20 mL/h); fever (rectal temperature, > 38 °C); altered mental status; lactic acidosis (7.61 meq/L ± 2.0 SE); and microbiologically confirmed...References1. HIGGINSSIVAKO'NEIL TED. Reversal of hypotension by continuous naloxone infusion in a ventilator dependent patient. Ann Intern Med. 1983;98:47-8. LinkGoogle Scholar2. FADENHOLADAY IJ. Experimental endotoxic shock: the pathophysiologic function of endorphins in treatment with opiate antagonists. J Infect Dis. 1980;142:229-38. CrossrefMedlineGoogle Scholar3. PETERSFRIEDMANJOHNSON WPM. Pressor effect of naloxone in septic shock. Lancet. 1981;1:529-32. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: East Carolina University School of Medicine Greenville, NC 27834 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNaloxone for shockTherapy of shock with naloxoneA comprehensive review of naloxone for the emergency physicianPharmacologic Management of Shock-Induced Renal DysfunctionHuman cardiovascular reactions to simulated hypovolaemia, modified by the opiate antagonist naloxoneNaloxone does not alter haemodynamics in cirrhosisConsiderations in the Therapy of Septic ShockThe cardiovascular actions of morphine and the endogenous opioid peptidesNaloxone and methylprednisolone sodium succinate enhance sympathomedullary discharge in patients with septic shockNaloxone in shock and toxic comaNaloxone: New therapeutic roles 1 April 1983Volume 98, Issue 4Page: 559-559KeywordsBlood pressureFeversHypotensionLactic acidosisShockSystolic pressureTemperature Issue Published: 1 April 1983 PDF DownloadLoading ...
Case 28-1971
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Henry J. Mankin, Walter G. J. Putschar
Journal: New England Journal of Medicine (1971)

Presentation of CaseA 42-year-old radiologist was admitted to the hospital because of pain in the right leg.He had been well until seven months previously, when he contracted gastroenteritis, with stool cultures that were positive for salmonella. All symptoms subsided without antibiotic treatment after two days, and he was well until six weeks before admission, when he began to have vague paresthesia about the anterolateral aspect of the right thigh. He was examined by a physician, who found no abnormality. X-ray films of the chest and lumbar spine were normal. A complete blood count was normal except for an . . .
F-18 FDG PET in Ormond Disease in a Patient With Renal Cell Carcinoma
Authors: Archi Agrawal, Narendra Nair, Nawab Baghel
Journal: Clinical Nuclear Medicine (2007)

A 41-year-old male, with left renal cell carcinoma, after radical nephrectomy was referred for a FDG PET scan to look for viable disease. A CT scan done prior to the PET study had shown a mass with soft tissue density in the pre and paraortic region with encasement of the aorta and IVC. The patient had undergone DJ stenting for right-sided hydronephrosis prior to the CT scan. A whole body FDG-PET scan showed an oblong area of intense FDG uptake in the periphery with mild to moderate FDG uptake in its center. The mass was seen to extend from just below the renal hilum to the level of the aortic bifurcation. Left nephrectomy status was evident. No other sites of abnormal FDG metabolism were noted. A delayed, limited scan of the abdominal area showed the SUV of the mass to decrease indicating that the pathology could be benign. The biopsy showed that it was retroperitoneal fibrosis. Ormond disease or retroperitoneal fibrosis (RPF) encompasses a range of diseases characterized by the presence of fibro-inflammatory tissue, which usually surrounds the abdominal aorta and iliac arteries and extends into the retroperitoneum to envelop neighboring structures, eg, ureters. The false positive FDG uptake in RPF is attributed to the presence of lymphocytes, plasma cells, fibroblasts and abundant macrophages. This report emphasizes the fact that such causes of false positive uptake of FDG should be kept in mind while reporting especially when looking for viable tumor.
Follow-Up of a "High-Expectations" Halfway House
Authors: JACK F. WILDER, MARIE KESSEL, STEPHEN C. CAULFIELD
Journal: American Journal of Psychiatry (1968)

The authors describe the first year's experience of Overing Apartments, a halfway house in which tenants are challenged to accept a full range of responsibilities early in their stay. The outcomes of 20 men and 22 women are evaluated. Prognostic criteria are presented, and the implications of a "high-expectations" halfway house are explored.
Low Plasma Adiponectin Levels Predict Progression of Coronary Artery Calcification
Authors: David M. Maahs, Lorraine G. Ogden, Gregory L. Kinney, Paul Wadwa, Janet K. Snell-Bergeon, Dana Dabelea, John E. Hokanson, James Ehrlich, Robert H. Eckel, Marian Rewers
Journal: Circulation (2005)

Circulating adiponectin levels are lower in men than in women and lower in advanced coronary artery disease, obesity, and type 2 but not type 1 diabetes. However, it is not known whether low adiponectin levels predict development of atherosclerosis independently of other cardiovascular risk factors.Progression of coronary artery calcification (CAC) over an average of 2.6 years (range, 1.6 to 3.3) was assessed in a cohort of patients with type 1 diabetes and nondiabetic subjects 19 to 59 years of age. In this nested case-control substudy, plasma adiponectin levels were measured in 101 cases with significant CAC progression and in 205 controls. Controls were oversampled on the basis of age, gender, diabetes status, and presence of baseline CAC. In conditional logistic regression adjusted for baseline CAC volume and other significant predictors of CAC progression, adiponectin levels were inversely related to progression of CAC in diabetic (OR, 0.47; 95% CI, 0.24 to 0.94) and nondiabetic (OR, 0.15; 95% CI, 0.05 to 0.40 for a doubling in adiponectin levels) subjects. Adjustment for additional cardiovascular risk factors did not change this association. In conditional logistic regression models by quartiles of plasma adiponectin levels, the probability value for trend was statistically significant for all participants (P<0.001) and nondiabetic participants (P<0.001) and was borderline for type 1 diabetics (P=0.08).Low plasma adiponectin levels are associated with progression of CAC in type 1 diabetic and nondiabetic subjects independently of other cardiovascular risk factors.