tbuckley/cabot-search huggingface dataset:
Cardiac Muscarinic Potassium Channel Activity Is Attenuated by Inhibitors of G <sub>βγ</sub>
Authors: Lawrence A. Nair, James Inglese, Robert Stoffel, Walter J. Koch, Robert J. Lefkowitz, Madan M. Kwatra, Augustus O. Grant
Journal: Circulation Research (1995)

Abstract The cardiac muscarinic potassium channel (I K.ACh ) is activated by a G protein upon receptor stimulation with acetylcholine. The G protein subunit responsible for activation (G α versus G βγ ) has been disputed. We used G βγ inhibitors derived from the β-adrenergic kinase 1 (βARK1) to assess the relative importance of G βγ in I K.ACh activation. In rabbit atrial myocytes, I K.ACh had a conductance of 49±6.2 pS. In inside-out patches, the mean open time was 1.60±0.57 ms, mean time constant (τ o ) was 1.59±0.53 ms, and mean closed time was 3.02±1.35 ms (n=38). βARK1 is a G βγ -sensitive enzyme that interacts with G βγ through a defined sequence near its carboxyl terminus. A 28-amino-acid peptide derived from the carboxyl terminus of βARK1 (peptide G) increased the closed time to 10.04 ms ( P &lt;.001) and decreased opening probability (N P o ) by 71% ( P &lt;.001). Fusion proteins containing the entire carboxyl terminus of βARK1, glutathione S -transferase βARK1ct and hexahistidine βARK1ct, decreased N P o by 67% ( P =.03) and 48% ( P =.009), respectively. They also both significantly increased the closed time. None of the inhibitors affected mean open time or channel amplitude. A control peptide derived from a neighboring region of βARK1 had no significant effect on I K.ACh activity. These results provide further evidence for the role of G βγ in the activation of I K.ACh .
Points from Letters: "Nearly 90% of The Work..."
Authors: J. W. Crossley
Journal: BMJ (1970)

regarding the subconsultant grade (31 Jan- uary, p. 304).Although I am happy to ac- cept that Mr. Bennett appears to have been misreported, nevertheless his suggestion is not one that would commend itself in any future staffing structure.Dr. Thompson stresses that his remarks were factual.However, by admitting that there are "medical assistants who already carry out
Berlin Heart EXCOR Pediatric Ventricular Assist Device for Bridge to Heart Transplantation in US Children
Authors: Christopher S. Almond, David L. Morales, Eugene H. Blackstone, Mark W. Turrentine, Michiaki Imamura, M. Patricia Massicotte, Lori C. Jordan, Eric J. Devaney, Chitra Ravishankar, Kirk R. Kanter, William Holman, Robert Kroslowitz, Christine Tjossem, Lucy Thuita, Gordon A. Cohen, Holger Buchholz, James D. St. Louis, Khanh Nguyen, Robert A. Niebler, Henry L. Walters, Brian Reemtsen, Peter D. Wearden, Olaf Reinhartz, Kristine J. Guleserian, Max B. Mitchell, Mark S. Bleiweis, Charles E. Canter, Tilman Humpl
Journal: Circulation (2013)

Recent data suggest that the Berlin Heart EXCOR Pediatric ventricular assist device is superior to extracorporeal membrane oxygenation for bridge to heart transplantation. Published data are limited to 1 in 4 children who received the device as part of the US clinical trial. We analyzed outcomes for all US children who received the EXCOR to characterize device outcomes in an unselected cohort and to identify risk factors for mortality to facilitate patient selection.This multicenter, prospective cohort study involved all children implanted with the Berlin Heart EXCOR Pediatric ventricular assist device at 47 centers from May 2007 through December 2010. Multiphase nonproportional hazards modeling was used to identify risk factors for early (<2 months) and late mortality. Of 204 children supported with the EXCOR, the median duration of support was 40 days (range, 1-435 days). Survival at 12 months was 75%, including 64% who reached transplantation, 6% who recovered, and 5% who were alive on the device. Multivariable analysis identified lower weight, biventricular assist device support, and elevated bilirubin as risk factors for early mortality and bilirubin extremes and renal dysfunction as risk factors for late mortality. Neurological dysfunction occurred in 29% and was the leading cause of death.Use of the Berlin Heart EXCOR has risen dramatically over the past decade. The EXCOR has emerged as a new treatment standard in the United States for pediatric bridge to transplantation. Three-quarters of children survived to transplantation or recovery; an important fraction experienced neurological dysfunction. Smaller patient size, renal dysfunction, hepatic dysfunction, and biventricular assist device use were associated with mortality, whereas extracorporeal membrane oxygenation before implantation and congenital heart disease were not.
COMPLETE INVERSION OF THE UTERUS WITH PROLAPSE.
Authors: A. C. OLMSTED
Journal: JAMA (1907)

The comparative infrequency of the condition and some unusual surroundings prompt the report of this case. <h3>Patient.</h3> —L., Shoshone squaw, aged 29. This was the sixth pregnancy and was normal so far as I was able to learn. She is half-civilized and lives in a frame house, but adheres to the custom of seeking solitude out of doors at the time of labor. <h3>History.</h3> —I was called Sept. 20, 1906, and was told at the time that the child had been born two hours, but the placenta had not yet come away. I reached the patient four and one-half hours after delivery, finding her in the sagebrush, near a mountain stream, lying on the ground with only a blanket for covering. <h3>Examination.</h3> —I found her suffering from shock and half-conscious; pulse was 135, but the extremities were warm. Her husband said that she had complained of but little pain. I
Abstract 4051: A mouse model of head and neck cancer with infrared-based molecular imaging
Authors: Anas Mouchli, Ziying Han, Jun Zheng, Shayanne A. Lajud, Bert W. O'Malley, Daqing Li
Journal: Cancer Research (2012)

Abstract Introduction Head and neck cancer (HNC) is notoriously difficult to treat and the five-year survival rate has improved very little over the past thirty years. Head and neck squamous cell carcinomas (HNSCC) mouse models are invaluable tools for furthering mechanistic HNC research. Molecular imaging (MI) is a promising new modality that may improve current HNC mouse models. Visible florescent proteins (VFPs) have been widely used with animal models for tumor detection using MI. However, the low emission wavelength of VFP results in its overlapping with the auto-fluorescence of many tissues and causes insufficient penetration into deeper tissues, preventing the application of VFP to track local and metastatic tumor progressions. The recent development of infrared-fluorescent protein (IFP) with Biliverdin as a chromophore has greatly advanced in vivo molecular imaging of deep tissues in animals. Hypothesis The ultimate goal of this study is to develop a novel orthotopic mouse model of HNC with regional spreading and distant metastasis tumors that closely mimics human HNC and can be accurately detected by a noninvasive IFP-based molecular imaging (MI) system. Methods A stable human HNC cell line expressing IFP was established. This stable cell line was used for generating a mouse model with HNC. The tumor formation and tumor progression with this model were accurately monitored by a MI system. Results The IFP signal was clearly detected in our mouse model of HNC. Scanned imaging demonstrated a progression pattern of tumor growth in this model. The tumor can be detected earlier with molecular imaging than by conventional external caliper measurement. Unlike surgical measurement, the tumor can be quantified without disturbing the tumor environment. More important, our data suggest that local-regional metastasis tumors can be detected with this model. Conclusion This novel animal model represents an orthotopic human HNC model. The IFP signals penetrate tissues well and can be detected in the deep tissues with this model. Thus, our model has the potential to be used for monitoring tumor spreading and metastasis of advanced stage HNC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4051. doi:1538-7445.AM2012-4051
Crossing Frontiers: Gerontology Emerges as a Science
Authors: David H. Solomon
Journal: JAMA (1997)

Professor Achenbaum has given us the first comprehensive history of gerontology. Although the book traces the origins of gerontologic thought in the last third of the 19th century, it focuses largely on 20th-century developments and events in the United States. It is highly readable, and its historical stories and biographies are useful and often heartwarming to someone like me who has been in, or in close touch with, gerontology and geriatrics from 1948 to the present. I particularly enjoyed the sections on Elie Metchnikoff and Ignatz Nascher. Metchnikoff presented one of the first testable modern hypotheses on the mechanism of aging and also preached an "optimistic philosophy of senescence," asserting that "science could someday alleviate, if not eradicate, the ravages of age." Nascher coined the term "geriatrics," expressed a detailed vision of the nature of the medical specialty, and was a social reformer, evincing a profound concern for the misery
AN UNUSUAL PATHOLOGIC CONDITION OF THE STOMACH WITH ABNORMAL OPENING INTO THE JEJUNUM
Authors: P. R. Casellas
Journal: JAMA (1926)

Mrs. B. H. H. was referred to us by Dr. Paul Rigney for gastro-intestinal examination. A liquid barium meal was given, the total volume of which was 19 ounces (562 cc.). It revealed a stomach shaped between the cow horn and fishhook type, slightly displaced to the left, very flexible and very movable. A gastrospasm at the cardiac end of the stomach causing esophageal retention was observed as soon as the meal was given. It partly disappeared with the patient in the prone position. From the lesser curvature, at the pars media, a large niche equal in size and shape to the pyloric end of the stomach could be seen. This pouch emptied rhythmically with the pyloric end of the stomach, which was seen in its normal position, so that the barium meal passed into the intestine through these two different channels. There was some peristaltic unrest, the meal passing
Impact of Smoking and Smoking Cessation on Outcomes in Bladder Cancer Patients Treated with Radical Cystectomy
Authors: Michael Rink, Emily C. Zabor, Helena Furberg, Evanguelos Xylinas, Behfar Ehdaie, Giacomo Novara, Marko Babjuk, Armin Pycha, Yair Lotan, Quoc-Dien Trinh, Felix K. Chun, Richard K. Lee, Pierre I. Karakiewicz, Margit Fisch, Brian D. Robinson, Douglas S. Scherr, Shahrokh F. Shariat
Journal: European Urology (2012)
TCT-512 Treatment of Masive Pulmonary Embolism with Percutaneous Rheolytic Thrombectomy: Hospital and Follow-up results
Authors: Carlos Fernandez-Pereira, Alfredo M. Rodriguez-Granillo, Juan Mieres, Roberto Cristodulo, Paola Renes, Lorena Arizmendi, Jhon R. Aldana, Benjamin Ugarte, Alfredo Rodriguez
Journal: Journal of the American College of Cardiology (2014)
The management of infective gastroenteritis in adults a consensus statement by an expert panel convened by the British Society for the study of infection
Authors: M. Farthing, R. Feldman, R. Finch, R. Fox, C. Leen, B. Mandal, P. Moss, D. Nathwani, F. Nye, A. Percival, R. Read, L. Ritchie, W.T.A. Todd, M. Wood
Journal: Journal of Infection (1996)
Causes of Renal Failure in Patients With Type 2 Diabetes Mellitus
Authors: Yujiro Kida
Journal: JAMA (2003)

in repetitive work: a follow-up study. Am J Ind Med. 2002;42:344-353. 2. Thomsen JF, Mikkelsen S. Interview data versus questionnaire data in the diagnosis of carpal tunnel syndrome in epidemiological studies. Occup Med (Lond). 2003;53:57-63. 3. Frost P, Andersen JH, Nielsen VK. Occurrence of carpal tunnel syndrome in relation to sustained high velocity and high force manual work. Scand J Work Environ Health. 1998;24:285-292.
A Rare Accident in Childbirth.
Authors: J. S. Hammond
Journal: JAMA (1898)

Butte, Mont., Feb. 19, 1898. <h3>To the Editor:</h3> —The patient, Mrs. G. H. M., aged 26 years, weight about 125 pounds, of medium height, native of Scotland, was married to her second husband seven months previously. She had twice miscarried, her last pregnancy being three years ago. She was taken in labor at full term on July 8, 1897, in the evening. She was having strong pains. Digital examination revealed only sufficient dilatation to admit point of forefinger. The waters had escaped. The presenting part could not be certainly diagnosed by vaginal touch and she was too tender and nervous for an abdominal palpation sufficiently thorough for a satisfactory diagnosis of presentation and position. The os was very rigid. After watching her for some time I noticed no progress whatever in dilatation and that she was bearing her pains very poorly. In the discharges there was not the faintest trace
An Address ON EXPERIMENTAL RESEARCH AND MEDICAL PROGRESS: Delivered at the Opening of the Winter Session, University College Hospital Medical School, London
Authors: J. Tweedy
Journal: BMJ (1909)

G1ENTLEMEN,-The thought which first seeks expression this occasion is one of sorrow for the loss, through sudden death, of one who was for many years a distinguished teacher in this school.At the end of last summer the friends and' colleagues of Dr. Radcliffe Crocker -expected with a reasonable degree of 'confidence would be present with 'us to-'day to take part inauguration of another Annus-Medicus.It has
Breathalyzer and Kitagawa-Wright Methods of Measuring Breath Alcohol
Authors: T. B. Begg, I. D. Hill, L. C. Nickolls
Journal: BMJ (1964)

venous blood-alcohol levels 30 minutes after the end of the alcoholic drink, and lower than the blood levels after longer intervals.Breath-alcohol levels reflect the arterial blood con- tent, and this would be expected to exceed the venous blood content during the phase of intestinal absorption of alcohol and
A Series of Twenty-Five Completed Ovariotomies
Authors: A. Doran
Journal: BMJ (1889)

when I became assistant-surgeon to the Samaritan Hospital, and October, 1889, I witnessed no less than 1,050 abdo- minal sections.I assisted in person at over half those operations, after clinical examination of nearly every patient, in Dr. Ban- tock's wards.Yet, spite of that experience, which cannot be reckoned as limited, I should be sorry to speak too positively on any of the contested points relating to ovariotomy and allied pro- cedures.Practice of the operation, a searching investigation into every dletail of nursing and after-treatment, and a close study of the records and statistical tables of experienced operators, are the chief agents in effecting progress.The cause of death in fatal cases must, whenever possible, be faithfully recorded.Every operator tends to put his trust in a system; he must find out how the system fails in every bad case, and must admit, if necessary, that the system may have been the cause of death.He must avoid a natural tendency to argue, on mere logical grounds, that hiis colleagues' fatal cases are due to his colleagues' respective systems, and that hiis own are to be explained by purely acci- dental circumstances for which his system and himself are in no way to blame.On the other hand, the less experienced operator must not talke for granted that the success of a senior is due, as that senior may honestly believe and maintain, to his system.The senior's brilliant results must depend, to a great extent, on hiis skill and experience, rather than on preference for the spray, or sliscarditug of antiseptics, or treatment of peritonitis by opium or by purgatives.A few years ago, in the course of a discussion on the claims of eminent rivals, at the Royal MIedical and Chirurgical Society, Mr. Savory observed that there was only one thing com- mon to both claimants.Their last cases were more successful than their first.This showed that success depended on the man rather than on his system.In my own practice I have taken what has been sent to me; some of the cases were easy, some difficult, I made no selection.To give full details of every case would be an impossibility.Yet since ovariotomy depends, perhaps, more upon matters of detail and care in after-treatment than any other operation, I have thought it advisable to append to the table a series of notes on matters of interest respecting each case.I regret that one im- portant and indeed essential factor, the efficacy of the nurse, can- not be estimated in statistical records.The expression "' a simple ovariotomy," is a relative term.Thus Case 5 was " simple " as regards manipulation, but the previouis
Non‐compaction cardiomyopathy associated with myocardial bridging: A frequently overlooked or misdiagnosed cardiomyopathy
Authors: Dursun Aras, Omac Tufekcioglu, Serkan Topaloglu, Ozcan Ozeke, Kumral Ergun, Ali Yildiz, Bulent Deveci, Sule Korkmaz
Journal: European Journal of Heart Failure (2006)
Cardiac Arrest after Triple-strength Plasma
Authors: D. B. Whitehouse
Journal: BMJ (1965)

vicaine are all of equal potency.Borica et al.' in a double-blind investigation involving 6,788 cases of mepivicaine administration found that in regard to penetrance, latency, and potency this drug was indistinguishable from lignocaine.Reporting over 1,000 cases given prilocaine, Crawford2 states, " On the basis of this study, it would appear that prilocaine is equally potent with lignocaine and mepivicaine."Lund and Cwik' found that with epidural blocks 2% prilocaine gave the same degree of analgesia and motor blockade as 2% lignocaine.
Abstract 3544: Jak/Stat signaling: A potential target for pancreatic cancer management
Authors: Gong Jingjing, Izhar S. Batth, Addanki P. Kumar
Journal: Cancer Research (2011)

Abstract NexrutineR (Nx) isolated from the bark of Phellodendron amurense is being sold as an anti-inflammatory herbal supplement over the counter in the US. Recent studies from our laboratory demonstrated its potential as an anti-prostatic agent by targeting multiple signaling pathways including Akt/CREB/NFkB/Cyclin D1/Cox-2 both in vitro and in vivo. Given the importance of some of these signaling pathways in multiple cancers, we explored its role in pancreatic cancer (PanCA) using variety of cell lines. Human pancreatic cancer cells that differ in the status of K-Ras (BxPC-3 with wild type K-Ras and Capan-2 with mutant K-Ras), non- tumorigenic HPNE-Ras, MIAPC and ASPC-1 were tested for growth inhibition, apoptosis, necrosis, Cox-2 expression and activity following treatment with Nx. Our data indicate that Nx can significantly inhibit proliferation of these cell lines differentially through induction of apoptosis and necrosis without any significant effect on cell cycle profile. Investigation of molecular mechanism of action identified a role for Jak1 and transcription factors NFkB and Stat3. Western blotting data show that Nx can inhibit the protein levels of pStat3 and Jak1 effectively without influencing the protein levels of total Stat3. Similarly Nx treatment decreased the DNA binding activities of both NFkB and Stat3. Chromatin immunoprecipitation assays revealed the binding of Stat3 to Cox-2 promoter. In addition combining Nx with Gemcitabine (standard of care treatment for PanCA) demonstrated strong synergistic growth inhibitory activity through modulation of Stat3. Overall, the present study unveils a novel interplay between Jak1/Stat3 and NFkB signaling in pancreatic cancer cells. These data further suggest that the targeted disruption of Jak1/Stat3 and NFkB may represent a valid therapeutic approach in this cancer. Supported by NCCAM (APK). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3544. doi:10.1158/1538-7445.AM2011-3544
Lower risk for alcohol-induced cirrhosis in wine drinkers
Authors: Ulrik Becker, Morten Grønbæk, Ditte Johansen, Thorkild I. A. Sørensen
Journal: Hepatology (2002)

Although there is a well-known relationship between total alcohol intake and future risk for cirrhosis, other factors such as the type of alcohol consumed are sparsely studied. The aim of this study was to assess the effects of wine compared with other types of alcoholic beverages on risk for alcohol-induced cirrhosis. In 3 prospective studies, 30,630 participants from the Copenhagen area were followed-up for a total observation time of 417,325 person-years. Information on weekly intake of beer, wine, and spirits, and sex, age, body mass index, smoking habits, and education was obtained from questionnaires. The primary outcome measures were first admission or death, with alcohol-induced cirrhosis obtained from death certificates and from the National Hospital Discharge Register. Data were analyzed by means of multiplicative Poisson regression models. We confirmed the increasing risk for cirrhosis with increasing alcohol intake. Individuals who drank more than 5 drinks per day had a relative risk of 14 to 20 for developing cirrhosis compared with non- or light drinkers. However, compared with individuals who drank no wine (relative risk set at 1.0), individuals drinking 16% to 30% wine of their total intake had a relative risk of 0.4 (95% confidence limits, 0.3-0.6) and those drinking 51% or more of wine had a relative risk of 0.3 (95% confidence limits, 0.2-0.5) for developing cirrhosis. In conclusion, the results suggest that a high intake of all 3 types of alcohol conveys an increased risk for cirrhosis, but wine drinkers are at a lower risk than beer and spirits drinkers.
The Nature of Suffering
Authors: Nicholas P. Lang
Journal: JAMA (1992)

The practice of medicine in the last decade of the 20th century would be unrecognizable to our colleagues of 30 years ago. As we look back, it is frequently very difficult to understand how we have arrived here. When we turn and look into the future, the picture becomes even more confused. We stand at the pinnacle of scientific achievement. Our understanding of disease extends down to the molecular level. Despite this, we are looked upon with fear and distrust by our patients and by insurers, lawyers, and the federal government. We are continually badgered by quality assurance groups who wish to have every action documented, every<i>i</i>dotted, and every t crossed. These efforts to ensure the provision of quality health care result in quality paperwork that has no relationship to health care. Why has a profession devoted to human care fallen on such hard times? Dr Eric Cassell
Chromosomal aberrations, the consequence of refractory hyperparathyroidism: Its relationship with biochemical parameters
Authors: Sandra Afonso, Íñigo Santamaría, Martín E. Guinsburg, Ana Otero Gómez, José Luis García Miranda, Rosa Jofré, Javier Menárguez, Jorge Cannata-Andía, Juan C. Cigudosa
Journal: Kidney International (2003)