tbuckley/cabot-search huggingface dataset:
1220 ABT-450/RITONAVIR (ABT-450/R) COMBINED WITH PEGYLATED INTERFERON ALPHA-2A AND RIBAVIRIN (SOC) AFTER 3-DAY MONOTHERAPY IN GENOTYPE 1 HCV-INFECTED TREATMENT-NAIVE SUBJECTS: 12-WEEK INTERIM EFFICACY AND SAFETY RESULTS
Authors: E. Lawitz, I. Gaultier, F. Poordad, D.E. Cohen, R. Menon, L.M. Larsen, T. Podsadecki, B. Bernstein
Journal: Journal of Hepatology (2011)
Patients with coronary artery disease treated with statins have decreased heat production from culprit lesions
Authors: Christodoulos Stefanadis, Konstantinos Toutouzas, Eleftherios Tsiamis, Manolis Vavouranakis, Ioannis Kallikazaros, Sophia Vaina, Christina Chrysochoou, Dimos Panagiotakos, Christos Pitsavos, Pavlos Toutouzas
Journal: Journal of the American College of Cardiology (2002)
Validation and clinical correlation of triplex CD3, CD8 and FOXP3 IHC of tumor-infiltrating lymphocytes in follicular lymphoma
Authors: James Mansfield, Christian Slater, Richard Byers
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts It is clear that immune cells play many sometimes conflicting roles in the tumor microenvironment and it would be extremely useful to be able to visualize the distributions of multiple phenotyped immune cells in-situ in solid tumors. However, obtaining phenotypic information about
Antipyrin in Whooping-Cough.
Authors: L. Harrison Mettler.
Journal: JAMA (1891)

<h3>Editor Jour. Amer. Med. Ass'n:</h3> —Though antipyrin has been recommended now for some time in the treatment of pertussis, I am surprised to find still a considerable amount of indifference in regard to its employment, either through ignorance of its beneficial effects or fear of its dangers. Like Sonnenberger, I am almost inclined to regard antipyrin as a specific in this affection, though in using the term<i>specific</i>, I am aware that the action of the drug is exercised not so much upon the disease itself as upon the nervous system, in quieting the reflex spasmodic cough. It seems to me that the conclusions drawn by Ssemtschenko, after a close and careful experimentation, oblige us to consider the real cause of pertussis a bacillus, probably the bacillus of Afanassjew. This bacillus is specific. It is found in the sputum about the fourth day, or even earlier. It multiplies in the
THE USE OP Tc-99m-METH0XY ISOBUTYL ISONITRILE (MIBI) IN EVALUATION OF PATIENTS WITH PRIMARY CARCINOMA OF THE BREAST: COMPARISON WITH Tl-201 (Tl)
Authors: A Waxman, G Ashok, A Kooba, J Yadegar, M Van Scoy-Mosher, L Ramanna, A Silberman, G Rosen
Journal: Clinical Nuclear Medicine (1992)

Waxman, A.; Ashok, G.; Kooba, A.; Yadegar, J.; Scoy-Mosher, M. Van; Ramanna, L.; Silberman, A.; Xosen, G. Author Information
The Dog in the Night-time
Authors: R. Asher
Journal: BMJ (1960)

Groups of organisms, groups of molecules, tend to behave in an expected way.But when we get down to the single molecule, we find it has no such tendency.We are dealing, not with inevitabilities, but with probabilities in the statistical sense-a very different matter.We should of course make every effort to comprehend the forces which lead a man to behave in a certain way.But we must recognize that in the factual evidence now available to us there is nothing which justifies us in saying, " He could do no other than he did."-Iam, etc., Cambridge.A. M. PANTIN.
Errors in Prescribing Methotrexate
Authors: Ben M. Lomaestro
Journal: JAMA (1992)

<h3>To the Editor.</h3> —We have systematically evaluated prescribing errors for the past 6 years.<sup>1</sup>Recently, we have observed recurrent prescribing errors involving methotrexate for rheumatoid arthritis. Treatment with methotrexate for rheumatoid arthritis usually involves a regimen of onceweekly administration of doses ranging from 2.5 to 35 mg.2,3 Daily administration of methotrexate greatly increases the potential for toxic effects from a given dose, as it does not allow an interval for the cellular recovery from methotrexate depletion of tetrahydrofolate.<sup>4</sup>Significant toxic effects have been reported following daily administration of methotrexate (for as little as 4 days) because of medication errors.<sup>4,5</sup> In the past year we observed five patients (three inpatients and two outpatients) for whom methotrexate prescribing errors occurred. Inpatient 1 was admitted acutely for unstable angina and eventually underwent coronary bypass grafting. His preadmission medications included 7.5 mg of methotrexate once weekly. During his hospitalization, he was
Measles Vaccination-Reply
Authors: David G. Addiss
Journal: JAMA (1990)

<h3>In Reply.—</h3> Dr Needles suggests that a recent mutation in the measles virus might account for the occurrence of measles due to secondary vaccine failure. We are aware of no laboratory data to support this view. If a clinically significant antigenic shift had occurred in recent years, we would expect a high incidence of measles in adults rather than the low rate currently observed. Furthermore, secondary measles vaccine failure has been reported since the early 1970s.<sup>1</sup> The data provided by Drs Polkowski and Hayner demonstrate that measles can occur even in persons who have received more than one measles vaccination prior to the onset of an outbreak. We observed the same phenomenon in three patients during the outbreak in Dane County. However, the Dearborn data lack sufficient statistical power to justify the conclusion that revaccination is of no benefit in persons initially vaccinated before 12 months of age.
Googling Ourselves — What Physicians Can Learn from Online Rating Sites
Authors: Shaili Jain
Journal: New England Journal of Medicine (2010)

I open the Google search page on my laptop, type in my name, and click "search." In the 0.22 second it takes for the 1540 results to appear, I have a flashback to my medical-student days, when exam results would be typed on white A4 paper and taped to a window adjacent to the main entrance of the medical school. It was a curious form of transparency, with every class member's results, whether fail, pass, or honors, on display for all to see. I remember my anxiety escalating to frantic heights as I pushed past my peers, some jumping for . . .
Carotid Endarterectomy Revisited
Authors: J. Philip Kistler, Karen L. Furie
Journal: New England Journal of Medicine (2000)

The importance of understanding the pathophysiologic basis of transient cerebral ischemia or ischemic stroke became clear with Fisher's original description of stroke in patients with atherothrombotic “occlusion of the internal carotid artery” in 1951.1 Support for this concept that different arterial disorders produce ischemic stroke with definite topologic features (specifically, size and location) grew with Fisher's further pathological descriptions of lacunar and embolic stroke.He was the first to recognize that proper therapy required a precise pathophysiologic diagnosis that included not only characterization and localization of the ischemic disease in the brain, but also knowledge of the arterial disease and . . .
Cross-Sectional Computed Tomographic Assessment Improves Accuracy of Aortic Annular Sizing for Transcatheter Aortic Valve Replacement and Reduces the Incidence of Paravalvular Aortic Regurgitation
Authors: Hasan Jilaihawi, Mohammad Kashif, Gregory Fontana, Azusa Furugen, Takahiro Shiota, Gerald Friede, Rakhee Makhija, Niraj Doctor, Martin B. Leon, Raj R. Makkar
Journal: Journal of the American College of Cardiology (2012)
Potential risks of health food products containing yohimbe extracts
Authors: P A G M De Smet, O S N M Smeets
Journal: BMJ (1994)

coping."Guidelines on referral can help to over- come such difficulties.Any suggested inquiry into death rates should cover all providers of long stay care.This would allow a comparison of the rates across all providers, thus keeping results for nursing homes in context.Death rates in nursing homes may not be appreciably different from those for other providers of long stay care.We must be careful when discussing the many factors that influence death rates, and particularly in any attempts to link death rates to care previously given.We agree with Bowman that our survey shows that the population in nursing homes is dynamic and changing.More research is required to address some of the points raised generally by our survey and the response to our paper.
Clinical experience with the Palmaz-Schatz coronary stent. Initial results of a multicenter study.
Authors: R A Schatz, D S Baim, M Leon, S G Ellis, S Goldberg, J W Hirshfeld, M W Cleman, H S Cabin, C Walker, J Stagg
Journal: Circulation (1991)

Stenting of native coronary arteries with a balloon-expandable stent was attempted in 226 patients after elective angioplasty. Delivery of the device was successful in 213 (94%) of the patients. Of these, 39 received aspirin and dipyridamole only (group 1) and 174 received aspirin, dipyridamole, and warfarin for 1-3 months (group 2). There was no abrupt closure (less than or equal to 1 day) or perioperative death in either group. In-hospital or perioperative complications in group 1 compared with group 2 were as follows: subacute closure (1-14 days), seven (18%) patients versus one (0.6%) patient, respectively, p less than 0.0001; myocardial infarction, five (13%) patients versus one (0.6%) patient, respectively; condition requiring urgent bypass surgery, one (2.5%) patient versus no patients, respectively. Thus, the incidence of major complications such as death, myocardial infarction, or a condition requiring urgent bypass surgery was 15% in group 1 and 0.6% in group 2. Clinical follow-up revealed that 92% of the patients were asymptomatic at 3 months after stenting compared with 6% before stenting (p less than 0.0001). Of the 13 patients who were symptomatic, nine underwent cardiac catheterization and, ultimately, successful elective coronary angioplasty or bypass surgery. We conclude that a high delivery success rate can be expected with this device and that clinical thrombosis is less frequent in anticoagulated patients than in nonanticoagulated patients. Furthermore, in this selected patient population, coronary stenting results in a low incidence of in-hospital and perioperative complications. Clinical success, defined by absence of symptoms, appears to be sustained at 3 months.
Chromomycosis: a review
Authors: Dorothy I. Vollum
Journal: British Journal of Dermatology (1977)

Journal Article Chromomycosis: a review Get access Dorothy I. Vollum Dorothy I. Vollum Lewisham Hospital, High Street, Lewisham, London SE13 6LH Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 96, Issue 4, 1 April 1977, Pages 454–458, https://doi.org/10.1111/j.1365-2133.1977.tb07145.x Published: 01 April 1977
Progressive Multifocal Leukoencephalopathy Associated with Ruxolitinib
Authors: Rowan Wathes, Simon Moule, Dragana Milojkovic
Journal: New England Journal of Medicine (2013)

Ruxolitinib blocks Janus kinase (JAK) 1 and 2 signaling, a pathway involved in host defenses. A case is reported in which progressive multifocal leukoencephalopathy developed in a 75-year-old man with myelofibrosis a few weeks after the initiation of ruxolitinib.
Prognostic Implications of the Difference Between Left Ventricular Ejection Fractions After Stress and at Rest in Addition to the Quantification of Myocardial Perfusion Abnormalities Obtained With Gated SPECT
Authors: Paulo A. Carvalho, Paula M. Aguiar, Gabriel B. Grossman, Janaina F. Moraes, Ilo S. Baptista, Vania N. Hirakata, Roberto T.F. Ludwig, Eduardo B. Ludwig
Journal: Clinical Nuclear Medicine (2012)

The prognostic significance of the difference between poststress and at rest left ventricular ejection fraction (ΔLVEF) in patients sent for diagnostic myocardial perfusion study (MPS) is not well characterized. The purpose of this study was to prospectively evaluate the ability of ΔLVEF in further risk stratifying these patients in addition to the severity/extent of myocardial perfusion abnormalities expressed as the total perfusion deficit at stress (sTPD), according to the type of stress used.Two-day 99mTc-MIBI MPS after stress and rest were obtained for 507 patients subdivided according to the type of stress used, sTPD values, and ΔLVEF. Subsequent cardiac events were determined through a standardized questionnaire applied 1, 2, and 6 years after MPS. Independent of the type of stress used, the 6-year event rate with progressive perfusion and functional abnormalities combined was significant for total events, all-cause death, cardiac death, and revascularization but not for myocardial infarct. When ΔLVEF decreased by more than -10%, only those individuals with sTPD of 5% or less had increased 6-year total event rates [5.9% vs 15% for those submitted to treadmill test (P < 0.001) and 8.3% vs 19% when submitted to pharmacological stress (P = 0.001)]. An sTPD greater than 5% was the only variable predictive of total events when multivariate analysis was applied (P < 0.001 for treadmill exercise and P = 0.033 for dipyridamole).Estimation of ΔLVEF in addition to sTPD seems to improve risk stratification for future events when ΔLVEF decreases by more than -10% for those individuals with normal or near-normal myocardial perfusion (sTPD ≤ 5%). An sTPD greater than 5% was a better prognostic indicator of future events when compared with ΔLVEF for individuals with greater perfusion abnormality at stress.
Chronic Idiopathic Pericardial Effusion without Tamponade
Authors: DANIEL C. CONNOLLY, THOMAS J. DRY, C. ALLEN GOOD, O. THERON CLAGETT, HOWARD B. BURCHELL
Journal: Circulation (1959)

Persistent pericardial effusion in the absence of obvious preceding or concurrent disease presents a baffling problem. In such cases chylopericardium, cholesterol pericarditis, lupus erythematosus, malignant disease, myxedema, severe anemia, and scleroderma, must be considered. Six cases are reported with large effusions present for from 1 to 11 years. The diagnostic measures to be used, the results of histologic examination, and the effects of surgery on the clinical course are discussed.
Effects of Ouabain on the Left Ventricular Response to Exercise in Patients with Angina Pectoris
Authors: D. LUKE GLANCY, LAWRENCE M. HIGGS, KEVIN P. O'BRIEN, STEPHEN E. EPSTEIN
Journal: Circulation (1971)

The response of the left ventricle to a level of supine bicycle exercise that induced angina, and the effects of ouabain (0.01 mg/kg) on this response were evaluated in 14 patients with coronary arterial disease. Before administration of ouabain, exercise was associated with depressed pumping performance of the left ventricle in four patients: stroke work fell with exercise while left ventricular end-diastolic pressure (LVEDP) increased. In five patients left ventricular (LV) performance was not frankly depressed, but nevertheless was abnormal: stroke work increased, but was accompanied by an inordinately large rise in LVEDP. In the remaining five patients LV function was essentially normal. Ouabain improved LV performance at rest in only a minority of patients, but during the stress of exercise, LV hemodynamics were improved by ouabain in 12 of the 14 patients. Five patients, however, continued to show either depressed or abnormal function with exercise after they were given ouabain. As judged by the relationship of LVEDP to LV peak dp/dt, left ventricular contractility was increased by ouabain in most patients both at rest and during exercise. Despite its beneficial effects on left ventricular performance, ouabain did not consistently alter either exercise tolerance or the LV tension-time index and pressure-rate product at which angina occurred.
Coexistence of Tubulins and ftsZ in Different Prosthecobacter Species
Authors: Martin Pilhofer, Giovanna Rosati, Wolfgang Ludwig, Karl-Heinz Schleifer, Giulio Petroni
Journal: Molecular Biology and Evolution (2007)

Prosthecobacter, one of the few cultivable representatives of the bacterial phylum Verrucomicrobia, is of increasing interest to the scientific community due to the presence of tubulin genes in its genome and the apparent absence of the bacterial homologue FtsZ that is normally involved in prokaryotic cell division. These findings suggested the possibility of a vicarious takeover of the FtsZ function through these novel tubulins and opened new scenarios on the possible evolution of bacterial cytoskeleton and cell division. In the present manuscript, we report the characterization of ftsZ and ftsA homologues in different Prosthecobacter species that also possess tubulin genes. Based on these findings, we propose an FtsZ-based cell division mechanism in Verrucomicrobia. The analysis of available genome data of Verrucomicrobia suggests that tubulins are not a feature common to all members of this phylum. Therefore, it can be assumed that Prosthecobacter acquired tubulins through horizontal gene transfer. The functional role of tubulins in Prosthecobacter remains enigmatic.
Gaps in the continuity of care and progress on patient safety
Authors: R. I Cook
Journal: BMJ (2000)

The patient safety movement includes a wide variety of approaches and views about how to characterise patient safety, study failure and success, and improve safety. Ultimately all these approaches make reference to the nature of technical work of practitioners at the “sharp end” in the complex, rapidly changing, intrinsically hazardous world of health care. 1 2 It is clear that a major activity of technical workers (physicians, nurses, technicians, pharmacists, and others) is coping with complexity and, in particular, coping with the gaps that complexity spawns.3 Exploration of gaps and the way practitioners anticipate, detect, and bridge them is a fruitful means of pursuing robust improvements in patient safety.

#### Summary points

Complex systems involve many gaps between people, stages, and processes

Analysis of accidents usually reveals the presence of many gaps, yet only rarely do gaps produce accidents

Safety is increased by understanding and reinforcing practitioners' normal ability to bridge gaps

This view contradicts the normal view that systems need to be isolated from the unreliable human element

We know little about how practitioners identify and bridge new gaps that occur when systems change

The notion of gaps is simple. Gaps are discontinuities in care. They may appear as losses of information or momentum or interruptions in delivery of care. In practice gaps rarely lead to overt failure. Rather, most gaps are anticipated, identified, and bridged andtheir consequences nullified by the technical work done at the sharp end. These gap driven activities are so intimately woven into the fabric of technical work that neither outsiders nor insiders recognise them as distinct from other technical work.

Gaps are most readily seen when they are aligned with organisational and institutionalboundaries that mark changes in responsibility or authority, different roles of professionals, or formal divisions of labour. For example, the loss of coherence in …
AMA's new chief executive draws criticism
Authors: F. Charatan
Journal: BMJ (2001)

Within a month of appointing Dr Michael Maves as its new chief executive vice president and chief executive officer, the American Medical Association has found the appointment under fire from a medical consumer group.

Dr Maves, aged 53, was executive vice president of the American Academy of Otolaryngology—Head and Neck Surgery from 1995 to 1999. He has served as professor and chairman of the …
Further Evolution Toward Effective Therapy for Acute Ischemic Stroke
Authors: Marc Fisher
Journal: JAMA (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and substantive advances are occurring. Recently, thrombolytic therapy with tissue-type plasminogen activator was approved for selected patients with acute ischemic stroke when therapy is started within 3 hours of onset. Streptokinase therapy for acute ischemic stroke has not been shown to be effective and is associated with an increased risk of hemorrhage, although it was not evaluated as early after stroke onset as tissue-type plasminogen activator. Various types of neuroprotective interventions are effective in animal models, but none has yet been proven effective in patients. In the future, combinations of thrombolytic and neuroprotective drugs may be used to attempt maximum rates of recovery after acute ischemic stroke. For combination therapy to achieve its maximum potential, patients with acute ischemic stroke will have to be carefully selected and treated.
Resource Utilization and Costs during the Initial Years of Lung Cancer Screening with Computed Tomography in Canada
Authors: Sonya Cressman, Stephen Lam, Martin C. Tammemagi, William K. Evans, Natasha B. Leighl, Dean A. Regier, Corneliu Bolbocean, Frances A. Shepherd, Ming-Sound Tsao, Daria Manos, Geoffrey Liu, Sukhinder Atkar-Khattra, Ian Cromwell, Michael R. Johnston, John R. Mayo, Annette McWilliams, Christian Couture, John C. English, John Goffin, David M. Hwang, Serge Puksa, Heidi Roberts, Alain Tremblay, Paul MacEachern, Paul Burrowes, Rick Bhatia, Richard J. Finley, Glenwood D. Goss, Garth Nicholas, Jean M. Seely, Harmanjatinder S. Sekhon, John Yee, Kayvan Amjadi, Jean-Claude Cutz, Diana N. Ionescu, Kazuhiro Yasufuku, Simon Martel, Kamyar Soghrati, Don D. Sin, Wan C. Tan, Stefan Urbanski, Zhaolin Xu, Stuart J. Peacock
Journal: Journal of Thoracic Oncology (2014)

It is estimated that millions of North Americans would qualify for lung cancer screening and that billions of dollars of national health expenditures would be required to support population-based computed tomography lung cancer screening programs. The decision to implement such programs should be informed by data on resource utilization and costs.Resource utilization data were collected prospectively from 2059 participants in the Pan-Canadian Early Detection of Lung Cancer Study using low-dose computed tomography (LDCT). Participants who had 2% or greater lung cancer risk over 3 years using a risk prediction tool were recruited from seven major cities across Canada. A cost analysis was conducted from the Canadian public payer's perspective for resources that were used for the screening and treatment of lung cancer in the initial years of the study.The average per-person cost for screening individuals with LDCT was $453 (95% confidence interval [CI], $400-$505) for the initial 18-months of screening following a baseline scan. The screening costs were highly dependent on the detected lung nodule size, presence of cancer, screening intervention, and the screening center. The mean per-person cost of treating lung cancer with curative surgery was $33,344 (95% CI, $31,553-$34,935) over 2 years. This was lower than the cost of treating advanced-stage lung cancer with chemotherapy, radiotherapy, or supportive care alone, ($47,792; 95% CI, $43,254-$52,200; p = 0.061).In the Pan-Canadian study, the average cost to screen individuals with a high risk for developing lung cancer using LDCT and the average initial cost of curative intent treatment were lower than the average per-person cost of treating advanced stage lung cancer which infrequently results in a cure.
Doing the books
Authors: T. Dalrymple
Journal: BMJ (2009)

The stage of life at which I desired more possessions is, thank goodness, now long past. On the whole I am content to be rather than to have—with one notable exception.

Antiquarian booksellers now send me their catalogues through the post, and last week I received two such. One was a joint production of two Parisian dealers and was itself a book of rare beauty. As soon as I opened it I realised that I had wasted my life completely and should have spent it in the singleminded pursuit of money so that I could have bought these wonderful medical books of the 15th and 16th centuries.

For example, there was Magnus Hundt’s Anthropologium de Hominis Dignitate, Natura …