Lacrimation and 5-Fluorouracil
Authors: N. CHRISTOPHIDIS
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 October 1978Lacrimation and 5-FluorouracilN. CHRISTOPHIDIS, M.B., I. LUCAS, PH.C., F. J. E. VAJDA, M.D., F.R.A.C.P., W. J. LOUIS, M.D., F.R.A.C.P.N. CHRISTOPHIDIS, M.B., I. LUCAS, PH.C., F. J. E. VAJDA, M.D., F.R.A.C.P., W. J. LOUIS, M.D., F.R.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-574_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently Haidak, Hurwitz, and Yeung (1) reported in your journal that excessive lacrimation occurred in six patients receiving weekly injections of 5-fluorouracil during a period of 6 to 12 months. One patient in this report showed evidence of tear-duct fibrosis on biopsy.We have previously reported (2, 3) studies of the pharmacokinetics of 5-fluorouracil in 12 patients with metastic carcinoma of the colon receiving weekly intravenous injections of 12 to 15 mg/kg body weight. Excessive lacrimation occurred in four of these patients, a frequency similar to that reported by Hamersley and associates (4). One patient complained of...References1. HAIDAKHURWITZYEUNG DBK: Tear-duct fibrosis (dacryostenosis) due to 5-fluorouracil. Ann Intern Med 88:657, 1978 LinkGoogle Scholar2. CHRISTOPHIDISVAJDALUCASDRUMMERMOONLOUIS NFIOWW: Excessive lacrimation on fluorouracil therapy associated with detectable concentrations of 5FU in tears and plasma. Proc Aust Soc Clin Exp Pharmacol, in press Google Scholar3. CHRISTOPHIDISVAJDALUCASDRUMMERMOONLOUIS NFIOWW: Fluorouracil therapy in patients with carcinoma of the large bowel: a pharmacokinetic comparison of various rates and routes of administration. Clin Pharmacokinet 3:330-336, 1978 CrossrefMedlineGoogle Scholar4. HAMERSLEYLUCEFLORENTZBURKHOLDERPEPPER JJTMJ: Excessive lacrimation from fluorouracil treatment. JAMA 225:748-749, 1973 CrossrefGoogle Scholar5. JANSEN G: Treatment of basal cell epitheliomas and active keratoses. JAMA 235:1152-1154, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Clinical Pharmacology and Therapeutics Unit Austin Hospital Heidelberg, 3084 Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBilateral Lacrimal Drainage Obstruction and Its Association With Secondary CausesLacrimal and Canalicular ToxicityDocetaxel-Associated EpiphoraOcular Surface, Ocular Adnexal, and Lacrimal Complications Associated With the Use of Systemic 5-FluorouracilLacrimal Duct Stenosis and Other Ocular Toxicity Associated with Adjuvant Cyclophosphamide, Methotrexate and 5-Fluorouracil Combination Chemotherapy for Early Stage Breast CancerOcular toxicity and cancer chemotherapy: A reviewPunctal and canalicular stenosis associated with systemic fluorouracil therapyOcular complications of systemic cancer chemotherapyCytotoxicity of antineoplastic agents on rabbit corneal epithelium in vitroOcular Side Effects of Cancer Chemotherapy 1 October 1978Volume 89, Issue 4Page: 574-574KeywordsBiopsyBody weightColonFibrosisIntravenous injectionsPharmacokinetics Issue Published: 1 October 1978 PDF downloadLoading ...