BACTEREMIA OWING TO GRAM-NEGATIVE BACILLI: EXPERIENCES IN THE TREATMENT OF 137 PATIENTS IN A 15-YEAR PERIOD
Authors: JOHN A. SPITTEL
Journal: Annals of Internal Medicine (1956)

Article1 February 1956BACTEREMIA OWING TO GRAM-NEGATIVE BACILLI: EXPERIENCES IN THE TREATMENT OF 137 PATIENTS IN A 15-YEAR PERIODJOHN A. SPITTEL JR., M.D., WILLIAM J. MARTIN, M.D., DONALD R. NICHOLS, M.D.JOHN A. SPITTEL JR., M.D.Search for more papers by this author, WILLIAM J. MARTIN, M.D.Search for more papers by this author, DONALD R. NICHOLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-2-302 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe evolution of effective antibiotic therapy has greatly altered the outlook of many infectious states, one of which is the invasion of the blood stream by microörganisms. With the multiplicity of antimicrobial agents now available, it behooves the physician to acquaint himself with the type of therapy most effective in any given infection.Experience with bacteremia at the Mayo Clinic before and after the advent of sulfonamide compounds was reported previously.1 More recently, some aspects of bacteremia owing to Escherichia coli,2Aerobacter aerogenes,3Pseudomonas aeruginosa4 and proteus organisms5 were reviewed.The present study was undertaken to review all cases of...Bibliography1. HerrellBrown WEAE: The treatment of septicemia: results before and since the advent of sulfamido compounds, J. A. M. A. 116: 179-183 (Jan. 18) 1941. CrossrefGoogle Scholar2. SpittelMartinWellmanGeraci JAWJWEJE: Bacteremia owing to Escherichia coli: a review of 65 cases, Proc. Staff Meet., Mayo Clin. 29: 447-453 (Aug. 11) 1954. MedlineGoogle Scholar3. MartinSpittelNicholsGeraci WJJADRJE: Bacteremia caused by Aerobacter aerogenes: review of 20 cases, Proc. Staff Meet., Mayo Clin. 29: 541-545 (Sept. 29) 1954. Google Scholar4. MartinSpittelWellmanGeraci WJJAWEJE: Bacteremia owing to Pseudomonas aeruginosa: review of 10 cases, Proc. Staff Meet., Mayo Clin. 29: 562-566 (Oct. 13) 1954. MedlineGoogle Scholar5. SpittelMartinGeraciNichols JAWJJEDR: Bacteremia owing to proteus organisms: a method of treatment, Proc. Staff Meet., Mayo Clin. 29: 225-228 (Apr. 21) 1954. MedlineGoogle Scholar6. WhippleHarris RLJF: B. coli septicemia in Laennec's cirrhosis of the liver, Ann. Int. Med. 33: 462-466 (Aug.) 1950. LinkGoogle Scholar7. Askey JM: Bacillus pyocyaneus septicemia: report of a case with unusual blood findings, California and West. Med. 32: 352-353 (May) 1930. MedlineGoogle Scholar8. Mackeen RA: Bacillus pyocyaneus in the blood stream in a case of agranulocytic angina, Canad. M. A. J. 24: 424-425 (Mar.) 1931. MedlineGoogle Scholar9. Barker LF: The clinical symptoms, bacteriologic findings and postmortem appearances in cases of infection of human beings with the Bacillus pyocyaneus (abstract), J. A. M. A. 29: 213-216 (July 31) 1897. CrossrefGoogle Scholar10. Stanley MM: Bacillus pyocyaneus infections: a review, report of cases and discussion of newer therapy including streptomycin, Am. J. Med. 2: 253-277 (Mar.); 347-367 (Apr.) 1947. CrossrefMedlineGoogle Scholar11. GeppertBakerCopplePulaski LJHJBIEJ: Pseudomonas infections in infants and children, J. Pediat. 41: 555-561 (Nov.) 1952. CrossrefMedlineGoogle Scholar12. FeltyKeefer ARCS: Bacillus coli sepsis: a clinical study of twenty-eight cases of blood stream infection by the colon bacillus, J. A. M. A. 82: 1430-1433 (May 3) 1924. CrossrefGoogle Scholar13. Jacob L: Über Allgemeininfektion durch Bacterium coli commune, Deutsches Arch. f. klin. Med. 97: 303-347 (Sept.) 1909. Google Scholar14. Keefer CS Chairman: Streptomycin in the treatment of infections: a report of one thousand cases, J. A. M. A. 132: 4-11 (Sept. 7) 1946. CrossrefMedlineGoogle Scholar15. KeeferHewitt CSWL: The therapeutic value of streptomycin: a study of 3,000 cases, 1948, J. W. Edwards, Ann Arbor, Michigan, pp. 17-18. Google Scholar16. Abrams HL: Septicemia due to Proteus vulgaris: review of the literature and report of a case cured by streptomycin, New England J. Med. 238: 185-187 (Feb. 5) 1948. CrossrefMedlineGoogle Scholar17. ArmstrongLarner CWAE: The effect of combinations of antibiotics on Pseudomonas aeruginosa and on Proteus vulgaris, in vitro and in vivo, J. Lab. and Clin. Med. 37: 584-592 (Apr.) 1951. MedlineGoogle Scholar18. FrankWilcoxFinland PFCM: In vitro sensitivity of Bacillus proteus and Pseudomonas aeruginosa to seven antibiotics (penicillin, streptomycin, bacitracin, polymyxin, Aerosporin, Aureomycin, and Chloromycetin), J. Lab. and Clin. Med. 35: 205-214 (Feb.) 1950. MedlineGoogle Scholar19. ErwinWaisbrenKruse CPBAR: Clinical and laboratory studies of infections due to Pseudomonas aeruginosa and pseudomonas species, Am. J. M. Sc. 226: 525-532 (Nov.) 1953. CrossrefMedlineGoogle Scholar20. Jawetz E: Infections with Pseudomonas aeruginosa: treated with polymyxin B, Arch. Int. Med. 89: 90-98 (Jan.) 1952. CrossrefGoogle Scholar21. McVayGuthrieSprunt LVFDH: Septicemia due to bacteroides: Aureomycin hydrochloride therapy in two cases due to Bacteroides funduliformis , J. A. M. A. 140: 1150-1152 (Aug. 6) 1949. CrossrefMedlineGoogle Scholar22. BrownWilliamsHerrell AEHLWE: Bacteroides septicemia: report of a case with recovery, J. A. M. A. 116: 402-404 (Feb. 1) 1941. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication July 29, 1955.From the Section of Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota. The Mayo Foundation is a part of the Graduate School of the University of Minnesota. 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Some Experiences Regarding Blood Cultures in a Medical UnitMICROCOCCAL BACTEREMIA WITHOUT ENDOCARDITIS: CLINICAL DATA AND THERAPEUTIC CONSIDERATIONS IN 109 CASES*ALEXANDER SCHIRGER, M.D., WILLIAM J. MARTIN, M.D., DONALD R. NICHOLS, M.D., F.A.C.P.STREPTOCOCCAL BACTEREMIA WITHOUT ENDOCARDITIS: CLINICAL OBSERVATIONS*ALEXANDER SCHIRGER, M.D., WILLIAM J. MARTIN, M.D., DONALD R. NICHOLS, M.D., F.A.C.P.OBSERVATIONS ON THE PATHOGENESIS, COURSE AND TREATMENT OF NONOBSTRUCTIVE PYELONEPHRITIS*H. D. BRAINERD, M.D., F.A.C.P., L. M. CECIL, M.D. 1 February 1956Volume 44, Issue 2Page: 302-315KeywordsBacteremiaBloodEscherichia coliGastroenterology and hepatologyGraduate medical educationPatientsPseudomonasPseudomonas aeruginosaRiversSulfonamide Issue Published: 1 February 1956 PDF downloadLoading ...