tbuckley/cabot-search huggingface dataset:
Abstract P2-16-06: Influence of trastuzumab pre-exposure in non metastatic disease to first line metastatic treatment efficacy including trastuzumab: The University Cancer Center - University Pierre &amp; Marie Curie (IUC-UPMC) experience
Authors: J Gligorov, S Vignot, S Richard, J-P Lotz, D Khayat, J-P Spano
Journal: Cancer Research (2013)

Abstract Background: Trastuzumab (TZB), is approved in France in adjuvant setting since 2005 for patients with HER2-positive breast cancer. The effectiveness of this treatment is well established, but little is known about the impact of pre-exposure to this drug in non metastatic disease and its effectiveness during its reintroduction in the metastatic disease. Methods: We extracted from the database of two Medical Oncology Departments from University Cancer Institute - University Pierre &amp; Marie Curie (IUC-UPMC), clinical parameters of patients treated in first-line HER2 positive metastatic breast cancer with treatments including TZB as the only antiHER2 treatment, between 2005 and 2011. We analyzed the impact of this treatment in patients who received adjuvant TZB and also in patients who did not. Results. During this period, 456 patients were treated with TZB for a non metastatic HER2 positive disease, and 103 patients for a metastatic HER2 positive disease. Among the 456 patients treated in the (neo)adjuvant setting, the relapse rate was 3% (n = 16). The remaining 87 patients treated with first-line metastatic TZB were not previously treated with TZB in the adjuvant setting (n = 68) or had HER2 positive metastatic disease at time of initial diagnosis (n = 19). For patients previously exposed to TZB (n = 16), response rate (RR) of first-line treatment including TZB was 57% (95% CI: 35-81%) and time to failure treatment (TTF) was 243 days (95% CI: 114 to 330 days). For patients who have not been previously exposed to TZB (n = 87), the RR of first-line treatment including TZB was 61% (95% CI: 49-74%) and TTF was 267 days (95% CI: 182-343 days). Conclusions: Despite the lack of direct comparison, it does not appear that treatment including TZB in non metastatic disease, will influence the efficacy of first-line treatment of metastatic featuring TZB reexposure. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P2-16-06.
Secretion by glucagonomas of a possible glucagon precursor.
Authors: G C Weir, E S Horton, T T Aoki, D Slovik, J Jaspan, A H Rubenstein
Journal: Journal of Clinical Investigation (1977)

Five patients with glucagonomas had elevated plasma levels of total glucagon immunoreactivity. Gel filtrations of these plasma samples on Bio-Gel P30 columns showed that most of the immunoreactivity eluted in the 3,500-(true glucagon) and 9,000-dalton fractions. After the administration of alpha cell effectors, changes in total glucagon immunoreactivity were seen which were accounted for primarily by the 3,500-dalton species, but there were also changes in the 9,000-dalton moiety. Venous effluent plasma from tumors of two subjects contained elevated concentrations of glucagon immunoreactivity in both fractions. When material from both the 3,500- and 9,000-dalton peaks were serially diluted in a glucagon immunoassay, parallel displacement curves were found, suggesting that both have similar or identical antigenic determinants. Thus, with conversion to a neoplastic state, alpha cells of glucagonomas, much like beta cells of insulinomas, may secrete an increased amount of a larger, 9,000-mol wt glucagon species which may be a prohormone.
Fate, transport, and interactions of heavy metals.
Authors: O R Serrano
Journal: Environmental Health Perspectives (1995)

Mishandling of hazardous wastes, like their unauthorized disposal in abandoned dump yards or sites, in river beds, estuaries or in the sea, causes substantial damage to the environment and its resources and, given the persistence and toxicity of these pollutants, they can seriously damage human health and quality of life. The importance of controlling management, transport, and disposal of toxic and hazardous substances in the years to come will be a crucial issue in the design and implementation of public policies. This is especially true for residents of such areas as the border between the United States and Mexico, where historically hazardous wastes have been a public health and environmental problem. The aim of this Conference on the Fate, Transport, and Interactions of Metals, A Joint United States-Mexico Conference, co-sponsored by the National Institute of Environmental Health Sciences, Superfund Basic Research Program, the National University of Mexico, Program for the Environment and the Pan American Health Organization, and hosted by the University of Arizona Center for Toxicology, College of Pharmacy, is to begin a joint effort by the United States and Mexico to better understand the complex problems related to heavy metals as hazardous wastes.
Youth Pregnancy: A Community Solution
Authors: James S. Marks
Journal: JAMA (1987)

The problem of preventing teen pregnancies has been especially perplexing in the United States. Despite evidence of recent declines, we have one of the highest rates of teen pregnancy in the developed world, and the economic costs of teen pregnancy are staggering. In 1985, $16.65 billion was spent on families begun when the mother was a teen; virtually all of those costs are associated with public assistance including Aid to Families With Dependent Children, Medicaid, and food stamps.<sup>1</sup> Educational efforts to offset the human and economic costs that attend teen pregnancies face formidable barriers. One is a marketing issue: sex sells everything. Sexual attractiveness is coupled with everything from independence to worldly sophistication and forms a predominant theme in every nook and cranny of commercial communication. These themes get the attention of adults and teens alike, but are especially alluring to adolescents who are grappling with their identity and
What Are the Potential Cost Savings from Legalizing Physician-Assisted Suicide?
Authors: Ezekiel J. Emanuel, Margaret P. Battin
Journal: New England Journal of Medicine (1998)

In the Washington v. Glucksberg and Vacco v. Quill decisions rejecting a constitutional right to physician-assisted suicide, the Supreme Court allowed each state to decide whether to legalize the intervention.1 In state legislatures rather than courtrooms, factual claims about the probable extent and implications of permitting physician-assisted suicide assume a preeminent role in the debate about legalization.2 Particularly sensitive in these discussions will be the issue of the potential cost savings from legalizing physician-assisted suicide, and how the savings might influence decision making by health care institutions, physicians, families, and terminally ill patients.3–6 Although we do not agree with . . .
Developing Curricula to Promote Preventive Medicine Skills
Authors: Richard Kent Zimmerman
Journal: JAMA (1997)

Vaccines are underused in the United States, resulting in needless morbidity. Many experts have concluded that clinician education is critical to increasing the nation's vaccination rates.To develop and evaluate case-based curricular materials on immunizations that promote preventive medicine skills.Before-and-after trial of an educational intervention.Medical schools and primary care residency programs from 20 institutions across the United States participated in the Teaching Immunization for Medical Education (TIME) project.A multidisciplinary team developed learning objectives, abstracted clinical cases, and created case-based modules that use contextual learning and small-group interaction to solve clinical and public health problems. The case-based methods are multistation clinical teaching scenarios (MCTS) and problem-based learning (PBL).Knowledge gained by learners from pretest to posttest and the overall ratings of the sessions by learners and facilitators based on evaluation questionnaires.Pretest and posttest results were obtained on a total of 1122 learners for all modules combined. For the MCTS method, mean scores increased from the 10-item pretest to the posttest by 3.1 items for measles, 3.8 for influenza, 1.8 for hepatitis B, 3.9 for pertussis, 1.9 for adult vaccination, 1.9 for childhood vaccination, and 2.6 for Haemophilus influenzae type b (P<.01 for each). For the PBL method, mean scores increased by 3.4 items for measles, 3.3 for influenza, 2.6 for hepatitis B, and 2.5 for pertussis (P<.01 for each). Most learners (MCTS, 98%; PBL, 89%) and most facilitators (MCTS, 97%; PBL, 100%) rated the sessions overall as very good or good.Use of TIME modules increases knowledge about immunizations, an essential step to improving vaccination practices of future clinicians. Given the realities of decreased faculty time and budgets, educators face major challenges in developing case-based curricula that prepare learners for the 21st century. Nationally tested libraries of cases such as the TIME modules address this dilemma.
SPECT IMAGING OF OPIOID RECEPTORS IN PRIMATES
Authors: K. S. Lee, H. K. Kayakiri, R. Saunders, J. G. Gorey, R. C. Coppola, K. C. Rice, D. R. Weinberger
Journal: Clinical Nuclear Medicine (1996)

Lee, K.; Kayakiri, H. K.; Saunders, R.; Gorey, J. G.; Coppola, R. C.; Rice, K. C.; Weinberger, D. R.Author Information
Reply from Authors re: Jens J. Rassweiler. Is LESS/NOTES Really More? Eur Urol 2011;59:48–50
Authors: Riccardo Autorino, Jeffrey A. Cadeddu, Mihir M. Desai, Matthew Gettman, Inderbir S. Gill, Louis R. Kavoussi, Estevão Lima, Francesco Montorsi, Lee Richstone, Jens U. Stolzenburg, Jihad H. Kaouk
Journal: European Urology (2010)
Heart-Type Fatty Acid-Binding Protein Predicts Long-Term Mortality and Re-Infarction in Consecutive Patients With Suspected Acute Coronary Syndrome Who Are Troponin-Negative
Authors: Karthik Viswanathan, Niamh Kilcullen, Christine Morrell, Sue J. Thistlethwaite, Mohan U. Sivananthan, Tajek B. Hassan, Julian H. Barth, Alistair S. Hall
Journal: Journal of the American College of Cardiology (2010)
SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM
Authors: Phil Gold, Samuel O. Freedman
Journal: The Journal of Experimental Medicine (1965)

A wide variety of human adult and fetal tissues were studied by immune-diffusion techniques in agar gel to determine whether they contained the tumor-specific antigen(s) previously found in coionic cancers. In the adult tissues it was demonstrated that identical antigens were present in all tested specimens of malignant tumors of the entodermally derived epithelium of the gastrointestinal tract and pancreas, but were absent from all other tested adult tissues. The common antigenic constituents, therefore, represent system-specific cancer antigens of the human digestive system. System-specific cancer antigens have not previously been demonstrated in humans. Experiments with fetal tissues demonstrated that identical antigens were also present in fetal gut, liver, and pancreas between 2 and 6 months of gestation. These components were named "carcinoembryonic" antigens of the human digestive system. On the basis of the present findings and the recent work regarding control of the expression of genetic potentialities in various types of cells, it was concluded that the carcinoembryonic antigens represent cellular constituents which are repressed during the course of differentiation of the normal digestive system epithelium and reappear in the corresponding malignant cells by a process of derepressive-dedifferentiation.
Suprarenal Abscess in the Neonate
Authors: ROBERT G. WELLS, JOHN R. STY, NORMAN B. HODGSON
Journal: Clinical Nuclear Medicine (1986)

Although suprarenal abscess in a newborn is rare, a prompt diagnosis is essential for proper patient management. The findings obtained with Tc-99m glucoheptonate renal imaging in a newborn with a right adrenal abscess are reported. A radionuclide renal imaging sequence over a 15-hour period demonstrated a “rim sign” which can be used to suggest the diagnosis. Radionuclide and ultrasound imaging of neonatal adrenal masses is discussed.
Activation of H+ conductance in neutrophils requires assembly of components of the respiratory burst oxidase but not its redox function.
Authors: A Nanda, J T Curnutte, S Grinstein
Journal: Journal of Clinical Investigation (1994)

In phagocytes, superoxide generation by the NADPH oxidase is accompanied by metabolic acid production. Cytoplasmic acidification during this metabolic burst is prevented by a combination of H+ extrusion mechanisms, including a unique H+ conductance. NADPH oxidase is deficient in chronic granulomatous disease (CGD) patients. The burst of acid production is absent in CGD patients lacking the 47-kD (p47-phox) or the 91-kD (gp91-phox) subunits of the oxidase. Activation of the H+ conductance is also defective in these patients suggesting that (a) the oxidase itself undertakes H+ translocation or (b) oxidase assembly is required to stimulate a separate H+ conducting entity. To discern between these possibilities, three rare forms of CGD were studied. In neutrophils expressing nonfunctional cytochrome b, the conductance was activated to near-normal levels, implying that functional oxidase is not required to activate H+ extrusion. CGD cells expressing diminished amounts of cytochrome displayed H+ conductance approaching normal levels, suggesting that the oxidase itself does not translocate H+. Finally, the conductance was only partially inhibited in patients lacking the 67-kD subunit, indicating that this component is not essential for stimulation of H+ transport. We propose that normal assembly of the oxidase subunits is required for optimal activation of a closely associated but distinct H+ conducting entity.
Cardiac Troponin T Isoform Expression Correlates With Pathophysiological Descriptors in Patients Who Underwent Corrective Surgery for Congenital Heart Disease
Authors: Ziad Saba, Rashid Nassar, Ross M. Ungerleider, Annette E. Oakeley, Page A.W. Anderson
Journal: Circulation (1996)

Background This study examined cardiac troponin T (cTnT) isoform expression in patients who had undergone surgery at Duke University Medical Center (Durham, NC) between December 1, 1993, and January 31, 1995, to correct congenital heart defects. The human heart expresses four cTnT isoforms (cTnT 1 through cTnT 4 ) whose sequence differences result from combinatorial alternative splicing of two exons. We have previously shown that cTnT 4 is expressed at higher levels in severely failing hearts from transplant patients. In this study, we tested the hypothesis that congenital heart defects that have a more negative effect on myocardial function increase cTnT 4 expression. We used the presence or absence of drug treatment for heart failure or congested circulation before surgery and the duration of inotropic support after corrective surgery as indicators of the pathophysiological state of the heart just before surgery. Methods and Results Right atrial appendage tissue was collected from 34 patients, 6 days to 35 years old (median age, 3.4 months). The amounts of the cTnT 1 through cTnT 4 isoforms, measured as a percentage of total cTnT, were determined from Western blots probed with MAb13-11, a cTnT-specific monoclonal antibody. We found that cTnT 4 expression correlated positively with the duration of inotropic support and was higher in patients who received drug treatment before surgery than in those who did not. Furthermore, we found that the percent of cTnT 4 was significantly higher in hearts with congenital defects that caused congestive failure than in hearts with tetralogy of Fallot. Conclusions These findings suggest that in patients with congenital cardiac defects, cTnT 4 expression is modulated by heart failure and is increased in hearts that are more hemodynamically stressed.
Time to act on nonsensical outpatient follow-up ratio targets
Authors: A. N. Bamji
Journal: BMJ (2012)

A year ago I wrote about imposed targets for outpatient new:follow-up ratios and their impact on chronic disease management,1 receiving many supportive comments in both medical circles and the lay press.

I hoped that common sense would prevail and that this damaging target would be abandoned. I was therefore appalled to learn from a colleague that quite the opposite was …
Concurrent oral lichen planus and primary sclerosing cholangitis
Authors: D.C. Tong, M.M. Ferguson
Journal: British Journal of Dermatology (2002)

Journal Article Concurrent oral lichen planus and primary sclerosing cholangitis Get access D.C. Tong, D.C. Tong Department of Stomatology, University of Otago, PO Box 647, Dunedin, New Zealand Search for other works by this author on: Oxford Academic Google Scholar M.M. Ferguson M.M. Ferguson Department of Stomatology, University of Otago, PO Box 647, Dunedin, New Zealand Professor M.M.Ferguson. E‐mail: martinferguson@stonebow.otago.ac.nz Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 2, 1 August 2002, Pages 356–358, https://doi.org/10.1046/j.1365-2133.2002.04773.x Published: 01 August 2002 Article history Accepted: 12 December 2001 Published: 01 August 2002
With His Hands
Authors: David Malebranche
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laparoscopic versus open mesh repair of inguinal hernia
Authors: J. Wellwood, M. Sculpher, D. Stoker
Journal: BMJ (1999)

EDITOR—Our paper on hernia repair produced much correspondence1 2.In response to the letter from Notaras we agree that patients unfit for general anaesthetic, and therefore not suitable for laparoscopic repair, would be suitable for local anaesthetic, and this is how we would treat them. We do not agree that the reduced pain after laparoscopic repair, the improved quality of life, and the faster return to work and other activities are unimportant to the patient. Our view that these constitute important improvements from the patients' perspective is borne out by our table showing patient satisfaction (table 6).

Rose et al point out the absence of serious complications in …
Ritodrine therapy associated with remission of pemphigoid gestationis
Authors: K.J.S. MacDonald, E.J. Raffle
Journal: British Journal of Dermatology (1984)

Journal Article Ritodrine therapy associated with remission of pemphigoid gestationis Get access K.J.S. MacDonald, K.J.S. MacDonald Department of Dermatology, University of Dundee. Search for other works by this author on: Oxford Academic Google Scholar E.J. Raffle E.J. Raffle Department of Dermatology, University of Dundee. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue 5, 1 November 1984, Pages 630–631, https://doi.org/10.1111/j.1365-2133.1984.tb06639.x Published: 01 November 1984
Academic base for general practice
Authors: P Curtis
Journal: BMJ (1994)

to prove what.There is a legal maxim that "he who asserts must prove."The person who asserts is the person who seeks to change the status quo.If junior doctors want their hours to be reduced they must prove that long hours are unnecessary for training or dangerous to health, or both.Poulsen cites anecdotal evidence, the recommendations of committees, and journal articles but fails to pro- duce any scientifically valid evidence to support either proposition.The House of Lords considered the proposed directive on working hours in 1990.The Lords commented that evidence on the effects of excessive working hours was conflicting and that more research was needed.2Common sense suggests that worldng excessive hours is bad for you.But if
EXPERIMENTAL OPERATIONS ON THE SIGMOID VALVES OF THE PULMONARY ARTERY
Authors: Alexis Carrel
Journal: The Journal of Experimental Medicine (1914)

Incision, suture, and cauterization of the sigmoid valves of the pulmonary artery have been performed successfully in dogs. In the first series of ten animals, there were only three accidents, probably from largely preventable causes, leading to the death of the animals.
I Promethean, bound deeply and fluidly among the brain's associative robotic networks
Authors: Robert B. Glassman
Journal: Behavioral and Brain Sciences (2007)

Merker's insightful broad review fertilely recasts the mind/brain issue, but the phenomenological appeals require additional considerations of behavioral and neural flexibility. Motor equivalences and perceptual constancies may be cortical contributions to a “robotic” tectal orientation mechanism. Intermediate “third layers” of associative neural networks, each with a few diffusely summing convergence-divergence modules, may be the economical expedient by which evolution has extended the limited unity-in-diversity of sensorimotor coordination to perception, action, thinking, and memory.
Persons at High Risk of Cancer
Authors: Alfred G. Knudson
Journal: New England Journal of Medicine (1979)

The remarkable family study of renal carcinoma reported in this issue of the Journal provides us with the first example of a dominantly inherited chromosomal aberration that imposes a high risk of a specific cancer. In this pedigree a translocation between chromosomes 3 and 8 is associated with an extraordinary risk of renal carcinoma. As in other familial cancers the median age of onset is considerably younger than for the general population and the tumor is often multifocal, with a probability that primary tumors will arise bilaterally that steadily increases with age. Each carrier of the genetic abnormality in the . . .
WHAT IS THE BEST ACCESS FOR ANGIOGRAPHY IN PATIENTS WITH A SINGLE IN-SITU LEFT MAMMARY ARTERY GRAFT
Authors: Yves Louvard, Guiseppe Ferrante, Thomas Hovasse, Thierry Unterseeh, Philippe Garot, Oscar Tavolaro, Hakim Benamer, Thierry Lefevre
Journal: Journal of the American College of Cardiology (2012)