Host Responses to Hepatitis B Infection: Hepatitis B Surface Antigen and Host Proteins
Authors: BARBARA WERNER
Journal: Annals of Internal Medicine (1975)

Editorials1 July 1975Host Responses to Hepatitis B Infection: Hepatitis B Surface Antigen and Host ProteinsBARBARA WERNER, PH.D., W. THOMAS LONDON, M.D., F.A.C.P.BARBARA WERNER, PH.D.Search for more papers by this author, W. THOMAS LONDON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-1-113 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn intriguing feature of infection with the agent that causes hepatitis B in man is the great variation in host response. The Dane particle, which is 45 nm in diameter and contains an internal core with antigenic specificity (HBcAg) and an outer surface component that is also antigenic (HBsAg, Australia antigen), is presumed to be the infectious virion of hepatitis B (HBV). The host response to HBV ranges from clinically inapparent infections to acute, chronic, and fulminant hepatitis. When infected, most persons produce an excess of HBsAg, which is readily detected in their serum and is seen by electron microscopy...References1. HOOFNAGLE J, GERETY R, and BARKER L: Antibody to hepatitis B-virus core in man. Lancet 2:869-873, 1973 CrossrefMedlineGoogle Scholar2. BLUMBERG B, LONDON W, and SUTNICK A: Australia antigen as a hepatitis virus. Variation in host response. Am J Med 48:1-8, 1970 CrossrefMedlineGoogle Scholar3. BLUMBERG B, ALTER H, and VISNICH S: A "new" antigen in leukemia sera. JAMA 191:541-546, 1965 CrossrefMedlineGoogle Scholar4. MILLMAN I, HUTANEN H, and MERINO F: Australia antigen: Physical and chemical properties. Res Commun Chem Pathol Pharmacol 2:667-686, 1971 MedlineGoogle Scholar5. CULLEN M, REED T, and PERT J: Human serum proteins detected in hepatitis-associated antigen prepared by different methods. Abstr Am Chem Soc 141, 1972 Google Scholar6. VIERUCCI A, LONDON W, and BLUMBERG B: Cross-reaction of antibodies to human lactoferrin with HBAg. Lancet 2:344, 1974 CrossrefMedlineGoogle Scholar7. BLUMBERG B, VIERUCCI A, and LONDON W: Association of antibodies to Australia antigen with anti-Gm antibodies in Italian patients with thalassemia. Nature (Lond) 236:28-30, 1972 CrossrefMedlineGoogle Scholar8. NATHENSON G, COHEN M, and MILLMAN I: Association of antibodies to Gm and antibodies to Australia antigen in adolescent drug addicts. Proc Soc Exp Biol Med 145:358-360, 1974 CrossrefMedlineGoogle Scholar9. NEURATH A, PRINCE A, and LIPPIN A: Hepatitis B antigen: antigenic sites related to human serum proteins revealed by affinity chromatography. Proc Natl Acad Sci USA 71:2663-2667, 1974 CrossrefMedlineGoogle Scholar10. KISTLER G and SONNABEND W: Antikorper gegen ein fetorenales Antigen in Hepatitis B Patienten, Tragern von Nierentumoren und gesunden Individuen. Schweiz Med Wochenschr 104:485-497, 1974 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BARBARA WERNER, PH.D.; W. THOMAS LONDON, M.D., F.A.C.P.Affiliations: The Institute for Cancer Research Fox Chase Cancer Center Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA case of childhood hepatitis B virus infection related primary hepatocellular carcinoma with short malignant transformation timeAdverse prognostic influence of hepatitis b virus infection in acute lymphoblastic leukemiaEarly Identification of Potentially Cured Patients with Acute Myelogenous Leukemia — A Recent ChallengeHepatitis and LeukemiaANTONIO JULIÁ, M.D., LORENZO FONT, M.D.Hepatitis and LeukemiaJOSEPH P. FIORE, M.D.Beneficial Effects of Hepatitis in Patients with Acute Myelogenous LeukemiaJAMES C. BARTON, M.D., MARCEL E. CONRAD, M.D.Familial clustering and immune response in family contacts of patients with HBsAg-positive liver cirrhosisCytologic localization of virus antigens and the role of the immune responseAustralia Antigen and the Biology of Hepatitis BThe Liver and the Antigens of Hepatitis BGARY L. GITNICK, M.D., LEONARD S. GOLDBERG, M.D., F.A.C.P., RONALD KORETZ, M.D., F.A.C.P., JOHN H. WALSH, M.D., F.A.C.P. 1 July 1975Volume 83, Issue 1Page: 113-114KeywordsAntigensChronic hepatitisElectron microscopyHepatitis BHepatitis B surface antigenHepatitis B virusInfectious hepatitisMembrane proteinsSpecificity ePublished: 1 December 2008 Issue Published: 1 July 1975 PDF downloadLoading ...