The Use of Oral Diazepam in Patients with Obstructive Lung Disease and Hypercapnia
Authors: RICHARD S. KRONENBERG
Journal: Annals of Internal Medicine (1975)

Letters1 July 1975The Use of Oral Diazepam in Patients with Obstructive Lung Disease and HypercapniaRICHARD S. KRONENBERG, M.D., F.A.C.P., MANUEL G. COSIO, M.D., JOHN E. STEVENSON, M.D., CHARLES W. DRAGE, M.D., F.A.C.P.RICHARD S. KRONENBERG, M.D., F.A.C.P., MANUEL G. COSIO, M.D., JOHN E. STEVENSON, M.D., CHARLES W. DRAGE, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-1-83 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the induction of acute respiratory failure in patients with chronic obstructive lung disease and CO2 retention by morphine or barbituates is well-known, few data are available on the use of oral antianxiety drugs in these patients. Accordingly, we studied the consequences of administering diazepam to six patients with severe but stable obstructive lung disease and hypercapnia.The patients were electively admitted to the hospital clinical research center for the study, for which they gave informed consent. Before beginning diazepam therapy they were studied with spirometry, blood gases, and measurement of their ventilatory responses to hypoxia and hypercapnia. These pretreatment...References1. CATCHLOVEKAFER RE: The effects of diazepam on respiration in patients with obstructive pulmonary disease. Anesthesiology 34:14-18, 1971 CrossrefMedlineGoogle Scholar2. CLARKCOLLINSTONG TJD: Respiratory depression caused by nitrazepam in patients with respiratory failure. Lancet 2:737-738, 1971 CrossrefMedlineGoogle Scholar3. MODEL D: Nitrazepam induced respiratory depression in chronic obstructive lung disease. Br J Dis Chest 67:128-130, 1973 CrossrefMedlineGoogle Scholar4. MODELBERRY DD: Effects of chlordiazepoxide in respiratory failure due to chronic bronchitis. Lancet 2:869-870, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Minnesota Veterans Administration Hospitals Minneapolis, Minnesota 55455 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBenzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adultsBenzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adultsDoes pharmacological treatment affect the sensation of breathlessness in terminal cancer patients?Effects of chronic administration of codeine and promethazine on breathlessness and exercise tolerance in patients with chronic airflow obstructionTreatment of Dyspnea with Psychotropic AgentsChemotherapy of AnxietyMortality conference: Suicide of an "appropriately" depressed medical inpatientAcute respiratory failure and CNS-depressing drugs.Drug Information Analysis Service 1 July 1975Volume 83, Issue 1Page: 83-84KeywordsBloodChronic obstructive pulmonary diseaseDiazepamDrugsHypercapniaHypoxiaLungsMorphineRespiratory failureSpirometry Issue Published: 1 July 1975 PDF DownloadLoading ...