tbuckley/cabot-search huggingface dataset:
Rh Isoimmunization
Authors: Tibor J. Greenwalt
Journal: JAMA (1984)

<h3>Development and Proof of a Hypothesis</h3> The accompanying case report by Levine and Stetson<sup>1</sup>is a fine example of the importance of careful clinical observation. Some may scoff at the publication of case reports, but to the astute scientist, a carefully documented study of an unusual patient represents an experiment of nature that may be the opportunity to explain a long-recorded but unexplained clinical mystery. Some credit must also go to the editorial staff ofThe Journalfor having published this and a related landmark, "Isoimmunization in Pregnancy: Its Possible Bearing on the Etiology of Erythroblastosis Foetalis," by Levine et al.<sup>2</sup> A new era in the clarification of the nature of erythroblastosis was opened by the classic observation of Diamond and colleagues<sup>3</sup>that icterus gravis, hydrops fetalis, and anemia of the newborn with erythroblastosis represented different grades of clinical severity of the same unknown underlying process. They
Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients
Authors: Luca Quagliata, Matthias S. Matter, Salvatore Piscuoglio, Leila Arabi, Christian Ruiz, Alfredo Procino, Michal Kovac, Francesca Moretti, Zuzanna Makowska, Tujana Boldanova, Jesper B. Andersen, Monika Hämmerle, Luigi Tornillo, Markus H. Heim, Sven Diederichs, Clemente Cillo, Luigi M. Terracciano
Journal: Hepatology (2013)

Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related death. Despite the advances in diagnosis and management of HCC, the biology of this tumor remains poorly understood. Recent evidence highlighted long noncoding RNAs (lncRNAs) as crucial determinants of HCC development. In this study we report the lncRNA HOXA transcript at the distal tip (HOTTIP) as significantly up-regulated in HCC specimens. The HOTTIP gene is located in physical contiguity with HOXA13 and directly controls the HOXA locus gene expression by way of interaction with the WDR5/MLL complex. HOX genes encode transcription factors regulating embryonic development and cell fate. We previously described HOX genes deregulation to be involved in hepatocarcinogenesis. Indeed, we observed the marked up-regulation of HOXA13 in HCC. Here, by correlating clinicopathological and expression data, we demonstrate that the levels of HOTTIP and HOXA13 are associated with HCC patients' clinical progression and predict disease outcome. In contrast to the majority of similar studies, our data were obtained from snap-frozen needle HCC biopsies (n=52) matched with their nonneoplastic counterparts collected from patients who had not yet received any HCC-tailored therapeutic treatments at the time of biopsy. In addition, taking advantage of gain and loss of function experiments in liver cancer-derived cell lines (HuH-6 and HuH-7), we uncover a novel bidirectional regulatory loop between HOTTIP/HOXA13. Our study highlights the key role of HOTTIP and HOXA13 in HCC development by associating their expression with metastasis and survival in HCC patients, provides novel insights on the function of lncRNA-driven hepatocarcinogenesis, and paves the way for further investigation about the possible role of HOTTIP as a predictive biomarker of HCC.
Bilateral Shoulder Fracture-Dislocations
Authors: Otto E. Aufranc
Journal: JAMA (1966)

Dr. Aufranc: This is the final in a series of three presentations devoted to the management of severe fractures involving the proximal end of the humerus and the shoulder joint. The great majority of patients with fractures in this area can be managed by simply supporting the arm and carefully supervising a gradually progressive program of shoulder exercises. Patient, repetitive, and careful attention to the rehabilitation of shoulder-joint function will reward both patient and physician with a functional range of shoulder motion. Normal motion is not often achieved, but sufficient motion for personal needs is almost always achieved. Today's case is unusual in that the patient was young, the fractures were bilateral, and major reconstructive surgery was necessary. Dr. Turner: A 36-year-old astronautical engineer sustained a generalized convulsion and was unconscious for at least two minutes following his seizure. When the patient regained consciousness, he noticed severe pain bilaterally in
Steps to a neurochemistry of personality
Authors: Andrew D. Lawrence, Matthias J. Koepp, Roger N. Gunn, Vincent J. Cunningham, Paul M. Grasby
Journal: Behavioral and Brain Sciences (1999)

Depue &amp; Collins's (D&amp;C's) work relies on extrapolation from data obtained through studies in experimental animals, and needs support from studies of the role of dopamine (DA) neurotransmission in human behaviour. Here we review evidence from two sources: (1) studies of patients with Parkinson's disease and (2) positron emission tomography (PET) studies of DA neurotransmission, which we believe lend support to Depue &amp; Collins's theory, and which can potentially form the basis for a true neurochemistry of personality.
MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type
Authors: Hiroaki Shibahara, Shugo Tamada, Michiyo Higashi, Masamichi Goto, Surinder K. Batra, Michael A. Hollingsworth, Kohzoh Imai, Suguru Yonezawa
Journal: Hepatology (2004)

Complete surgical resection of the tumor is the sole approach to improve the cure rate of patients with intrahepatic cholangiocarcinoma-mass forming type (ICC-MF). Although patients are treated by curative resection, many of them show poor outcome. Mucin (MUC)4 expression has been implicated as a marker for diagnosis and progression of pancreatic adenocarcinomas, but there is no study of the relationship between MUC4 expression and patient's prognosis in ICC-MF. In the present study, we examined the expression profile of MUC4 in ICC-MF tissue from 27 patients using immunohistochemistry. MUC4 was expressed in the carcinoma tissues of 10 (37%) of the 27 ICC-MF tumors, whereas it was not expressed in normal liver tissue. Because MUC4 is an intramembrane ligand for receptor tyrosine kinase ErbB2 and is related with regulation of p27, we also compared the MUC4 expression with ErbB2 and p27 expressions in ICC-MFs. The patients with MUC4 and ErbB2 double positive expression showed a short survival period compared to non-expressing patients. MUC4 and p27 showed no relationship. The univariate analysis showed that tumor size, intrahepatic metastasis, lymph node metastasis, MUC4 expression, and MUC1 expression were statistically significant risk factors affecting the outcome of the patients with ICC-MF. The multivariate analysis demonstrated that MUC4 expression, as well as surgical margin, were statistically significant independent risk factors. In conclusion, the results suggest that expression of MUC4 in ICC-MF is a new independent factor for poor prognosis and is a useful marker to predict the outcome of the patients with ICC-MF. (Hepatology 2004;39:220-229.)
Impact of a Diagnostic Cerebrospinal Fluid Enterovirus Polymerase Chain Reaction Test on Patient Management
Authors: Christian Ramers
Journal: JAMA (2000)

Enterovirus (EV) infection, the most common cause of aseptic meningitis, can be rapidly diagnosed with an EV-specific reverse transcriptase polymerase chain reaction (EV-PCR) test. However, no studies have examined EV-PCR in a clinical context in which it is routinely used.To determine the impact of EV-PCR testing on diagnosis and clinical management of suspected aseptic meningitis cases.Retrospective review of electronic medical records from a 220-bed tertiary care pediatric medical center in San Diego, Calif.A total of 276 pediatric patients for whom a diagnostic EV-PCR test was performed during the calendar year 1998.Clinical parameters such as length of stay, medication use, and ancillary test use.One hundred thirty-seven patients (49.6%) had a positive cerebrospinal fluid EV-PCR result. Enterovirus-positive patients with results available before hospital discharge (n=95) had significantly fewer ancillary tests performed (26% vs 72% with at least 1 test performed; P<.001), received intravenous antibiotics for less time (median, 2.0 vs 3.5 days; P<.001), and had shorter hospital stays (median, 42 vs 71.5 hours; P<.001) than EV-negative patients (n=92). A positive EV-PCR result was associated with more rapid hospital discharge (median EV-PCR-to-discharge time, 5.2 hours) compared with a negative result (median EV-PCR-to-discharge time, 27.4 hours; P<.001).Our results suggest that a positive EV-PCR result may affect clinical decision making and can promote rapid discharge of patients, and that unnecessary diagnostic and therapeutic interventions can be reduced by use of EV-PCR testing. JAMA. 2000;283:2680-2685.
Reduced steady state-based peripheral blood stem cell harvest rate in multiple myeloma treated with bortezomib-based induction regimens
Authors: S Manier, M Barthelemy, G Fouquet, C Prod’homme, E Le Ray, P Samarcq, M P Noel, L Terriou, T Facon, C Cossment, F Boulanger, X Leleu
Journal: Leukemia (2012)
What Industry Thinks about the Massachusetts Medical Society's Program of Medical Care for the People of Massachusetts
Authors: Jarvis Hunt
Journal: New England Journal of Medicine (1947)

GRANTING that it is necessary to provide more adequate medical care for our citizens, the question arises, How shall this care be distributed? How shall it be administered, and how shall it be financed? Naturally, the further question also immediately arises, What part should the United States Government have in this program? At the present time several bills regarding medical care are pending before Congress. The most important of them are the Wagner–Murray–Dingell Bill (S. 1606), the Maternity and Child Welfare Act of 1945 (S. 1318) and the Taft Bill (S. 545).The basic principles of medical care as presented . . .
6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study
Authors: Smita Bhatia, Wendy Landier, Lindsey Hageman, Heeyoung Kim, Yanjun Chen, Kristine R. Crews, William E. Evans, Bruce Bostrom, Jacqueline Casillas, David S. Dickens, Kelly W. Maloney, Joseph P. Neglia, Yaddanapudi Ravindranath, A. Kim Ritchey, F. Lennie Wong, Mary V. Relling
Journal: Blood (2014)
High Dose Inhaled Budesonide in the Treatment of Severe Steroid‐Dependent Asthmatics
Authors: E. ÄDELROTH, L. ROSENHALL, C. GLENNOW
Journal: Allergy (1985)

Thirty‐eight patients with chronic asthma requiring continuous oral corticosteroid treatment took part in a 2‐year study. Budesonide, a new inhalation steroid with high topical activity and low systemic effects, was given in stepwise increasing doses from 200 μg daily up to 800–1600 μg daily and prednisolone doses were decreased gradually on an individual basis. After 2 years, 18 patients had been able to cease oral prednisolone treatment, 11 had decreased the dose by 50%, three by 50% and two patients had increased their dose. At the end of the study the majority of patients (26) were using 800 ng budesonide daily and seven, 1200 μg or more daily. There were two dropouts, one due to local side effects and one to a severe pulmonary eosinophilia. Ten patients had local side effects in the form of hoarseness and/or sore throat, and 13 patients had steroid withdrawal symptoms such as arthralgia and myalgia. The asthma conditon in all patients was improved, as indicated by the reduced need for hospital admissions. The results indicate that high doses of budesonide should be tried before starting maintenance therapy with oral steroids.
Abstract 4732: Vasohibine-1 negative and EZH2 positive may predict the prognosis of cholangiocarcinoma
Authors: Shigeki Nakagawa, Yasuo Sakamoto, Ryuma Tokunaga, Takaaki Higashi, Keita Sakamoto, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu, Hideo Baba
Journal: Cancer Research (2014)

Abstract Background: Vasohibin-1 (VASH1) is isolated as an endogenous angiogenesis inhibitor produced by the vascular endothelium, and the status of VASH1 expression has been documented in various cancer prognosis. Some reports shows that VASH1 was negatively regulated by enhancer of zeste homolog 2 (EZH2) epigenetically. The aim of this study was to assess the relationship between EZH2 and VASH1, and the prognostic value of this two molecules in intrahepatic cholangiocarcinoma (ICC) patients. Method: We examine 47 cases of intrahepatic cholangiocarcinoma to which the R0 liver resection had been performed by our department between 1993 years and 2010. Immunohistochemical staining of VASH1 and EZH2 was performed using paraffin-embedded block, and we examined the relation among the expression of VASH1 and a clinicopathological factor (sex, age, tumor diameter, tumor number, differentiation level, microscopic vascular invasion, and metastasis in lymph node), EZH2 expression, recurrence-free survival (RFS) and overall survival (OS). Result: VASH1 and EZH2 positivity was observed in 24 (51.1%) and 24 (51.1%) patients respectively, and VASH1 positivity was inversely correlated with EZH2 high expression (R=0.3870, p=0.0018). VASH1 positivity was not significantly correlate with RFS or OS. On the other hands, VASH1 negative and EZH2 positive was observed in 17 (36.2%) patients, and was a significant disadvantage to both RFS (relative risk (RR) 3.39, 95% confidence interval (CI) 1.28-8.67, p=0.0157) and OS (RR 3.69, 95% CI 1.20-11.2, 0.0237) in univariate Cox hazard analysis. In multivariate analysis, VASH1 negative and EZH2 positive group was an independent risk factor for both RFS (RR 4.19, 95% CI 1.33-13.13, p=0.0150), and OS (RR 8.11, 95% CI 2.01-42.1, p=0.0030). Conclusion: The expression of VASH1 was inversely correlate with EZH2 expression. VASH1 negative and EZH2 positive was an independent risk factor for OS and DFS in ICC patients. Citation Format: Shigeki Nakagawa, Yasuo Sakamoto, Ryuma Tokunaga, Takaaki Higashi, Keita Sakamoto, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu, Hideo Baba. Vasohibine-1 negative and EZH2 positive may predict the prognosis of cholangiocarcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4732. doi:10.1158/1538-7445.AM2014-4732
Vertical gaze palsy in barbiturate intoxication.
Authors: R H Edis, F L Mastaglia
Journal: BMJ (1977)

Vertical gaze palsy in barbiturate intoxicationParalysis of conjugate gaze is not a well-recognised sign of barbiturate intoxication in the conscious patient.1 2We describe here the occurrence of a vertical gaze palsy in a patient intoxicated with a medium-acting barbiturate. Case reportA 28-year-old Australian woman (75-5 kg) presented with a four-day history of right frontal headache, drowsiness, photophobia, ataxia, anorexia, and vomiting.She denied ingestion of drugs, other than prednisone (5 mg/ day) and theophyllin when required for her asthma, and there was no history of drug intoxication.There was no family history of adverse drug effects.She was afebrile and the general examination showed nothing abnormal.There was mild neck stiffness.She was drowsy and mildly dysarthric but could co-operate fully with the examination.There was mild engorgement of retinal veins in the right eye.Pupil size and reaction were normal.Horizontal gaze was full with bilateral fine gaze-evoked nystagmus in the supine position, which was unsustained when she sat up.Convergence was absent.Conjugate upward gaze was completely absent and no upward movement of the eyes occurred on forceful eye closure or with the oculocephalic manoeuvre.Downward gaze was full.The remainder of the examination showed nothing abnormal apart from generalised depression of deep tendon reflexes and mild ataxia of gait.
Nocturnal Strokes and Arterial Hypotension
Authors: JAMES F. TOOLE
Journal: Annals of Internal Medicine (1968)

Editorial Notes1 May 1968Nocturnal Strokes and Arterial HypotensionJAMES F. TOOLE, M.D., F.A.C.P.JAMES F. TOOLE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1132 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptZulch and Hossman (1) recently reported that arterial blood pressure fluctuates in a diurnal rhythm that has mid-morning and early evening peaks and a nocturnal trough with a nadir occurring sometime between midnight and 4AM. Because the hypotensive phase in the biorhythm of blood pressure coincides with the time when cerebral infarctions most commonly occur, they have postulated that hypotension may be the mechanism underlying some of these episodes. Their suggestion, while intriguing and possibly correct, is founded on hypothesis, not evidence. While it is true that the onset of cerebral infarctions is usually during repose, there is no...References1. ZULCHHOSSMAN KJV: Twenty-four hour rhythm of human blood pressure. German Med. Monthly 12: 513, 1967. MedlineGoogle Scholar2. KENDELLMARSHALL REJ: Role of hypotension in the genesis of transient focal cerebral ischaemic attacks. Brit. Med. J. 2: 344, 1963. CrossrefMedlineGoogle Scholar3. DICKINSON CJ: Neurogenic Hypertension, Blackwell Scientific Publications, Ltd., London, 1965. Google Scholar4. Biological Clocks: Symposia Quant. Biol. (Cold Spring Harbor), vol. 25, Waverly Press, Inc., Baltimore, 1960. Google Scholar5. BEDWELLSTRUGHOLD TCH: Bioastronautics and the Exploration of Space, Defense Document Center, Washington, D. C., 1965, pp. 465-484. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bowman Gray School of Medicine Winston-Salem, N. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAspects of Human ChronopathologyHirninfarktDiurnal Blood Pressure Variations in Cerebrovascular DiseaseMAURICE GROSS, M.D., M.R.C.P. 1 May 1968Volume 68, Issue 5Page: 1132-1133KeywordsBlood pressureHypotensionInfarctionStroke Issue Published: 1 May 1968 PDF DownloadLoading ...
New agenda for general practice computing
Authors: P G Nutley
Journal: BMJ (1990)

In the same publication we also reported the phenomenon of upward setting of the glucoregulatory centre in diabetes (as alluded to by Dr Ryder and colleagues).We showed that those diabetic subjects who retained adequate counterregulatory capacity did so at a significantly higher blood glucose concentration than did the normal group.Our data, however, do not confirm the suggestion of Dr Ryder and colleagues that recurrent hypoglycaemia may be the cause of the counter- regulatory failure.We studied both insulin dependent and non-insulin dependent diabetic subjects and found that the counterregulatory defect occurred in both types of diabetes.It is highly unlikely that recurrent hypoglycaemia occurred in the subject using only diet to control diabetes or the two subjects with tablet failure.Thus recurrent hypoglycaemia is probably not the sole cause of this abnormality.
Blood Levels from Orally Administered Penicillins G and V
Authors: Wilfred F. Jones, Maxwell Finland
Journal: New England Journal of Medicine (1955)

SEVERAL natural penicillins develop during fermentation and differ by the side chain attached through the acid amide linkage to the thiazolidine-beta-lactam skeleton of the penicillin molecule. If the concentration of the appropriate organic acid precursor is increased in the nutrient medium, the equilibrium regarding the types of penicillin produced may be shifted in favor of the type with this particular organic acid side chain. Similarly, the provision of new precursors can lead to the biosynthesis by the Penicillium mold of entirely new penicillins1 that may have pharmacologic and physicochemical properties quite different from those of benzylpenicillin (penicillin G), and may . . .
Bilateral, Calcified Subclavian Arterial Aneurysms in a Young Adult Male
Authors: William O. Dobbins
Journal: New England Journal of Medicine (1961)

BECAUSE of the unusual nature of the x-ray and pathological findings a report of the following case, with a brief review of the literature concerning aneurysms of the subclavian artery, seems justified.Case ReportJ.B. (F.S. 5364), an 18-year-old single Eskimo, was admitted to Firland Sanatorium on December 21, 1954, because of abnormal x-ray findings in the chest known since 1951. At the time of admission he was asymptomatic. The x-ray report, dated December 2, was interpreted as showing moderately advanced pulmonary tuberculosis, probably active.The past history indicated that he had had multiple chronic eye ulcers as a child . . .
Local Excision Plus Irradiation for Breast Cancer
Authors: Morris J. Wizenberg
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The MEDICAL NEWS item, " 'Simulated Partial Mastectomy' Leaves Tumor Cells in Most Breasts" (228:1081, 1974), contributes only irrelevant material to the present controversy in regard to conservative surgery for the treatment of breast cancer. The argument is not whether radical surgery is better than local excision, but whether radical excision is better than local excision plus irradiation. If we were all convinced that local excision could, indeed, remove the entire tumor, postsurgical irradiation would be unnecessary. Proponents of the combined technique have long recognized the inadequacy of the simple surgical procedure alone, and are, therefore, not surprised to find residual disease. Nor should we be surprised in the second half of the 20th century to learn that radiation therapy can, in fact, eradicate carcinoma. Is not the time past when we should have recognized that what we are treating is a patient rather than a disease? If
WT1 protein expression in childhood acute leukemia
Authors: Gunter Kerst, Nina Bergold, Friederike Gieseke, Elaine Coustan‐Smith, Peter Lang, Marketa Kalinova, Rupert Handgretinger, Jan Trka, Ingo Müller
Journal: American Journal of Hematology (2007)

Abstract In patients with acute leukemia, Wilms' tumor gene 1 (WT1) has been used as a target for the detection of minimal residual disease (MRD) by PCR techniques. The expression of WT1 protein, however, has not been extensively studied. To determine the relation between expression of WT1 transcripts and of the encoded protein, we examined leukemic cell lines and primary childhood leukemia samples using both real‐time quantitative PCR (RQ‐PCR) and flow cytometry. WT1 protein was highly expressed in the leukemic cell lines K562, HL‐60, PLB 985, KG‐1a and CEM. By contrast, 40 primary samples of acute lymphoblastic leukemia (ALL; B‐ALL, n = 15 and T‐ALL, n = 10) and acute myeloid leukemia ( n = 15) expressed low levels of WT1 protein. RQ‐PCR detected WT1 transcript levels in the same range as reported in earlier studies in childhood acute leukemia. The results of this study indicate the following: (i) there are considerable discrepancies between WT1 transcripts and protein expression; (ii) WT1 is not a suitable marker for flow cytometric MRD detection in childhood acute leukemia. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Dendritic cells of IgA nephropathy patients have an impaired capacity to induce IgA production in naïve B cells
Authors: Jan-Willem Eijgenraam, Andrea M. Woltman, Sylvia W.A. Kamerling, Francine Briere, Johan W. De Fijter, Mohamed R. Daha, Cees Van Kooten
Journal: Kidney International (2005)
A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy
Authors: Cheng-Qiong Mao, Jin-Zhi Du, Tian-Meng Sun, Yan-Dan Yao, Pei-Zhuo Zhang, Er-Wei Song, Jun Wang
Journal: Biomaterials (2011)