tbuckley/cabot-search huggingface dataset:
"THE RELATION OF MEDICAL EDUCATION TO THE MEDICAL PLANT"
Authors: G. Canby Robinson
Journal: JAMA (1923)

<h3>To the Editor:</h3> —The letter of Dr. Theodore Diller calls attention to two problems of medical education which are among the most serious that have to be faced at this time. They are the numerical limitation of students and the high cost of medical education. The limitation of the number of students is a problem now being faced by many of the Grade A schools. As a matter of fact, Vanderbilt University does not at present admit nearly all the properly qualified students that apply for entrance to the medical school, and has not done so for several years. The university acts on the principle, as do the medical schools of the United States generally, that it admits only the number of students which it can properly teach and train. This problem is not local, nor is it a condition arising from the fact that Vanderbilt University is to have
QUANTITATIVE STUDY OF COLLAGEN CONTENT IN EXPERIMENTAL CIRRHOSIS
Authors: Thomas G. Morrione
Journal: The Journal of Experimental Medicine (1947)

Quantitative determinations of collagen were carried out on rat livers showing cirrhosis due to p-dimethylaminoazobenzene and carbon tetrachloride. A twofold increase in collagen content occurred in cirrhosis due to p-dimethylaminoazobenzene. The average total hepatic collagen as well as the per cent collagen content were doubled. The collagen content after 1(1/2) months of normal diet had fallen to normal levels. In cirrhosis due to carbon tetrachloride, the collagen content underwent about a fourfold increase. Partial reversal with significant decrease in collagen content occurred after stopping the carbon tetrachloride. The incomplete resorption of collagen in this group can be attributed to impaired hepatic regeneration following the prolonged administration of the compound. The chemical values for collagen parallel the quantitative evaluations of collagen content, based on microscopic examination of liver sections stained for reticulum. Deposition of collagen in hepatic cirrhosis is not necessarily an irreversible phenomenon.
Oesophageal complications in epidermolysis bullosa.
Authors: S P Travis, R A Eady, R P Thompson
Journal: Gut (1991)

We have shown previously that stimulation of heterologously expressed P2Y<sub>1</sub> nucleotide receptors inhibits M-type K<sup>+</sup> currents in sympathetic neurons. We now report that activation of endogenous P2Y<sub>1</sub> receptors induces inhibition of the M-current in rat CA1/CA3 hippocampal pyramidal cells in primary neuron cultures. The P2Y<sub>1</sub> agonist adenosine 5′-[β-thio]diphosphate trilithium salt (ADPβS) inhibited M-current by up to 52% with an IC<sub>50</sub> of 84 nm. The hydrolyzable agonist ADP (10 μm) produced 32% inhibition, whereas the metabotropic glutamate receptor 1/5 agonist DHPG [(S)-3,5-dihydroxyphenylglycine] (10 μm) inhibited M-current by 44%. The M-channel blocker XE991 [10,10-bis(4-pyridinylmethyl)-9(10<i>H</i>)-anthracenone dihydrochloride] produced 73% inhibition at 3 μm; neither ADPβS nor ADP produced additional inhibition in the presence of XE991. The effect of ADPβS was prevented by a specific P2Y<sub>1</sub> antagonist, MRS 2179 (2′-deoxy-<i>N</i>′-methyladenosine-3′,5′-bisphosphate tetra-ammonium salt) (30 μm). Inhibition of the M-current by ADPβS was accompanied by increased neuronal firing in response to injected current pulses. The neurons responding to ADPβS were judged to be pyramidal cells on the basis of (1) morphology, (2) firing characteristics, and (3) their distinctive staining for the pyramidal cell marker neurogranin. Strong immunostaining for P2Y<sub>1</sub> receptors was shown in most cells in these cultures: 74% of the cells were positive for both P2Y<sub>1</sub> and neurogranin, whereas 16% were only P2Y<sub>1</sub> positive. These results show the presence of functional M-current-inhibitory P2Y<sub>1</sub> receptors on hippocampal pyramidal neurons, as predicted from their effects when expressed in sympathetic neurons. However, the mechanism of inhibition in the two cell types seems to differ because, unlike nucleotide-mediated M-current inhibition in sympathetic neurons, that in hippocampal neurons did not appear to result from raised intracellular calcium
Surrogate Outcomes in Clinical Trials
Authors: Staffan Svensson, David B. Menkes, Joel Lexchin
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
AUDIO-TAPE/SLIDE TEACHING AIDS*
Authors: R. R. PHILLIPS
Journal: British Journal of Dermatology (1970)

Journal Article AUDIO‐TAPE/SLIDE TEACHING AIDS Get access R. R. PHILLIPS R. R. PHILLIPS Department of Medical Illustration, Institute of Dermatology, London, W.C.2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 83, Issue 4, 1 October 1970, Pages 504–505, https://doi.org/10.1111/j.1365-2133.1970.tb15087.x Published: 01 October 1970
Relationship between chronic dyspnea and expiratory flow limitation in patients with chronic obstructive pulmonary disease.
Authors: L Eltayara, M R Becklake, C A Volta, J Milic-Emili
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

The purpose of this study was to assess whether expiratory flow limitation (FL), as measured by applying negative pressure at the mouth during tidal expiration, is a better predictor of dyspnea than routine spirometry measurements. The study population consisted of 117 ambulatory patients with COPD. Dyspnea was assessed according to the ATS-DLD respiratory Questionnaire. Expiratory flow limitation was measured in supine and sitting positions, and expressed as a percentage of the expired control tidal volume affected by flow limitation (FL, % VT). Using Spearman's rank correlation (rs), we found that the correlation of dyspnea scale with FL was stronger (rs > 0.5) than with FVC (rs < -0.3) or FEV1 (rs < -0.4) in both positions. In a multiple regression analysis FL remained the best predictor of dyspnea scale even after adjustment for FEV1 (% pred). Finally, FL was almost as sensitive as FEV1 (% pred) but much more specific in assessing the severity of dyspnea scale. These findings suggest that expiratory flow limitation as measured by the negative expiratory pressure technique may be more useful in the evaluation of dyspnea in patients with COPD than spirometry measurements.
Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma
Authors: S Kumar, A Dispenzieri, M Q Lacy, S R Hayman, F K Buadi, D A Gastineau, M R Litzow, R Fonseca, V Roy, S V Rajkumar, M A Gertz
Journal: Leukemia (2007)
HEMATURIA AS THE EARLIEST OR ONLY SYMPTOM OF INFANTILE SCURVY.
Authors: JOHN LOVETT MORSE
Journal: JAMA (1904)

Very soon after the existence of infantile scurvy as a clinical entity was established, it was recognized that hematuria was a not uncommon symptom. All writers on the subject refer to hematuria as one of the symptoms, but very few lay any stress on it or emphasize its importance. Holt<sup>1</sup>says that it is seen in about 5 per cent. of the cases while Rotch<sup>2</sup>says that it has been noticed in a certain number and that it is well to examine the urine when this disease is suspected. While all writers mention hematuria as one of the symptoms of scurvy, most of them give the impression that it is rather an unusual symptom and certainly not an important one. Very few call attention to the fact that it may be the earliest symptom, and hence, for a time, the only symptom. Holt<sup>1</sup>says that in rare cases hematuria has
How to Achieve a High-Performance Health Care System in the United States
Authors: Arvind R. Cavale
Journal: Annals of Internal Medicine (2008)

Letters6 May 2008How to Achieve a High-Performance Health Care System in the United StatesArvind R. Cavale, MDArvind R. Cavale, MDFrom Feasterville, PA 19053.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-9-200805060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:With due respect to the extensive effort by the authors of the College's recent position paper (1), I would like to highlight several points of disagreement and disappointment. First, when advocating for a government-run, single-payer system (federal or state), we must decide whether this will resemble the current Medicare or Medicaid system. The latter will obviously lead to most enrollees losing real-time or real-world access to their physicians (similar to how current Medicaid HMOs, while “covering” a large portion of the low-income population, don't have any participating physicians for their members to get care from).Second, the ...Reference1. Public Policy Committee of the American College of Physicians. Achieving a high-performance health care system with universal access: what the United States can learn from other countries. Ann Intern Med. 2008;148:55-75. [PMID: 18056654] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Feasterville, PA 19053.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAchieving a High-Performance Health Care System with Universal Access: What the United States Can Learn from Other CountriesHow to Achieve a High-Performance Health Care System in the United States Richard S. Leff How to Achieve a High-Performance Health Care System in the United States Richard L. Cruess and Sylvia R. Cruess How to Achieve a High-Performance Health Care System in the United States Thomas James III How to Achieve a High-Performance Health Care System in the United States Harvey S. Zarren How to Achieve a High-Performance Health Care System in the United States Jack A. Ginsburg , Robert B. Doherty , and J. Fred Ralston Jr. How to Achieve a High-Performance Health Care System in the United States S. Ward Casscells and MG Elder Granger Metrics 6 May 2008Volume 148, Issue 9Page: 709KeywordsConflicts of interestHealth careInformation technologyLegislationMedicareMotivation ePublished: 6 May 2008 Issue Published: 6 May 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Diabetic Ketosis Caused by the Insulin Analog Aspart–Induced Anti-Insulin Antibody: Successful Treatment With the Newest Insulin Analog Glulisine
Authors: Hidekatsu Yanai, Hiroki Adachi, Hidetaka Hamasaki
Journal: Diabetes Care (2011)

Anti-insulin antibodies induce immunological insulin resistance and poor diabetic control in insulin-treated diabetic patients. Recently, the prevalence and levels of anti-insulin antibodies have remarkably decreased as a consequence of the purity of insulin preparations and human insulin (1). The insulin analog insulin aspart exists as hexamers that rapidly dissociate into monomers and dimmers after the subcutaneous injection; therefore, insulin aspart is supposed to be less immunogenic than human recombinant insulin (2).

Here we report a type 1 diabetic patient who developed diabetic ketosis induced by severe insulin resistance caused by anti-insulin antibody after 6 years of insulin aspart use. He was treated with the newest insulin analog, insulin glulisine, which resulted …
Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR
Authors: D M Ross, S Branford, J F Seymour, A P Schwarer, C Arthur, P A Bartley, C Slader, C Field, P Dang, R J Filshie, A K Mills, A P Grigg, J V Melo, T P Hughes
Journal: Leukemia (2010)
Aneurysm of the Renal-Artery Bifurcation
Authors: Charles H. Fuller, Paul C. Peters
Journal: New England Journal of Medicine (1962)

ANEURYSM of the renal artery is not a rare clinical finding. Garritano1 reviewed 175 cases in 1957 and noted that a third had been reported in the preceding five years. Individual series of 102 , 3 and 12 cases4 have been reported. Most of these aneurysms are located peripherally, involving the bifurcation of the main renal artery or one of its branches, in contrast to the less common, more centrally placed aneurysm, which is often a poststenotic dilatation. The ring shadow on roentgenograms of the abdomen, produced by calcification within the wall of the aneurysm, is often diagnostic. The diagnosis is best . . .
Medical Affairs: Being the President's Address, delivered at the Annual Meeting of the Northern Branch, June 30th, 1874
Authors: A. Legat
Journal: BMJ (1874)

_7URNAL 73 the voltaic (galvanic, or "constant current") instrument, as it possesses therapeutical properties which the volta-magnetic does not.Excellent guide-books on this subject have been published by Dr. Russell Reynolds and Dr. Tibbits, and a larger treatise by Dr. Althaus.The medical staff of the National Hospital for Paralysis, in Queen
Treatment of chronic constipation with cisapride and placebo.
Authors: S A Muller-Lissner
Journal: Gut (1987)

The effect of cisapride (20 mg bid), a new prokinetic drug, on bowel habits and laxative consumption was studied in patients with idiopathic painless constipation and chronic laxative intake. After a four week base line period, spontaneous defection (frequency without laxative intake) and total defecation (total frequency) were measured. Patients with a spontaneous defecation of less than three stools per week entered the treatment period and were randomly assigned to double blind treatment with either cisapride (n = 64) or placebo (n = 62). After eight weeks of treatment, a four week run out phase on single blind placebo medication was conducted. Cisapride and placebo increased spontaneous stool frequency from 1.1 +/- 0.2 SEM to 3.0 +/- 0.2 per week (p less than 0.001) and from 1.2 +/- 0.1 to 1.5 +/- 0.2 (p greater than 0.05), respectively. Laxative consumption was decreased from 3.6 +/- 0.3 to 1.8 +/- 0.2 doses/week by cisapride (p less than 0.001) and from 3.3 +/- 0.3 to 2.8 +/- 0.3 by placebo (p less than 0.05). Both drugs improved constipation as assessed by the patient by means of a visual analogue scale, but cisapride did so to a larger extent than placebo. The effects of cisapride partly outlasted active medication by at least four weeks. It is concluded that cisapride improves bowel habits in patients with idiopathic constipation and reduces laxative consumption.
Authors' reply to Brunet
Authors: A. Burns
Journal: BMJ (2013)

Brunet questions the validity of the dementia diagnosis rate, which is expressed as a simple percentage.1 2 The numerator is the annual return made as part of the primary care Quality and Outcomes Framework process and the denominator is the estimated number of people with the diagnosis (estimated prevalence). This figure is based on the best evidence of prevalence, which comes from the latest epidemiological information. The Cognitive Function and Ageing Study3 and …
Abstract 4519: Small cell lung cancers lack expression of argininosuccinate synthase (ASS) and are sensitive to arginine deprivation using arginine deiminase-PEG20 (ADI-PEG20)
Authors: Marcus P. Kelly, Achim A. Jungbluth, Bor-Wen Wu, John Bomalaski, Gerd Ritter, Lloyd J. Old
Journal: Cancer Research (2010)

Abstract Various tumor types have been shown to lack expression of the enzyme argininosuccinate synthase (ASS) that is required for the synthesis of arginine and thus rely on exogenous sources for protein synthesis requirements. These tumors may be sensitive to arginine deprivation, and the absence of ASS expression may serve as a biomarker for this sensitivity. Arginine deiminase (ADI) is a microbial enzyme that has been shown to efficiently lower peripheral blood arginine. Its therapeutic efficacy has been previously explored in the treatment of melanoma and hepatocellular cancer in early phase clinical trials but clinical efficacy in these tumor types has been limited. However, other tumor types lacking ASS may be more sensitive to arginine depletion. We have investigated ASS expression in human small cell lung cancer (SCLC) tumor tissue by immunohistochemistry (IHC) and have so far found that about 43% (7/16) of SCLC tumors were negative for ASS. SCLC has a robust initial response to chemotherapy but the majority of cases relapse and there remain limited options in the treatment of refractory disease. Based on the IHC findings and the need for novel therapies in recurrent SCLC, we explored the effects of pegylated ADI (ADI-PEG20) mediated arginine deprivation in SCLC in vitro and in vivo. We screened a panel of 10 human SCLC cell lines for ASS mRNA and protein expression by Real Time PCR and Western blot analysis. Little or no ASS was observed in 50% (5 of 10) of the SCLC cell lines examined and this frequency is approximately equivalent to that found in the SCLC tumor tissues. In cell proliferation assays a clear correlation between expression of ASS and sensitivity to ADI-PEG20 was detected. Biochemical analysis of the mechanism of ADI-PEG20 induced cell death in ADI sensitive cell lines revealed induction of autophagy and cell death through caspase independent mechanisms. Assessment of ADI-PEG20 activity in vivo using mice bearing SCLC xenografts demonstrated that ADI-PEG20 treatment of ASS negative SCLC xenografts caused significant and dose dependent inhibition of tumor growth, while no effect was observed with placebo controls. These results suggest a role for ADI-PEG20 in the treatment of SCLC, and a clinical trial exploring this treatment in patients with ASS negative SCLC by IHC has been initiated. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4519.
Principles and Practice of Toxicology in Public Health
Authors: Jeffrey Brent
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Hemorrhagic Shock on the Heart and Circulation of Intact Dogs
Authors: DONALD B. HACKEL, WALTER T. GOODALE
Journal: Circulation (1955)

The metabolic, hemodynamic and pathologic effects of hemorrhagic shock on the hearts of intact dogs have been studied, using the technique of venous catheterization of the coronary sinus. Metabolic studies demonstrated an alteration in the pattern of myocardial carbohydrate metabolism during shock and evidence for a relative myocardial oxygen deficiency. Subendocardial hemorrhage or necrosis was found in the left ventricles of some of the dogs.
243. Transplantation of Neonatal NOD/SCID/MPSVII Mice with Human Mesenchymal Stem Cells
Authors: Phillip E. Herrbrich, Todd E. Meyerrose, Alex A. Hofling, Mark Sands, Jan A. Nolta
Journal: Molecular Therapy (2005)

In this study we assessed the transfer and expression of the gene for beta-glucuronidase (GUSB) into multiple tissues by infusing normal human mesenchymal stem cells (MSC) into unconditioned neonatal NOD/SCID/MPSVII (GUSB null) mice. In this study, pups were transplanted before 3 days of age using the facial vein injection strategy. We hypothesized that neonatal pups would provide a rapidly growing environment for engraftment and expansion of transplanted normal human MSC into different tissues. The Sands laboratory has used the MPSVII mouse for many years to study disease progression, including neural defects, and to study correction of the disease by gene replacement therapies. In order to study cellular therapies using normal human cells, the murine MPSVII mutation was backcrossed for ten generations onto the NOD/SCID strain. Human umbilical cord blood CD34+ cells engraft in the resultant NOD/SCID/GUSB null strain to levels of 86% marrow replacement, similar to the NOD/SCID parent (Hofling 2004). The tissues of the mice can be homogenized and subjected to a GUSB enzyme assay, and plotted against a standard curve composed of normal human and GUSB null mouse cells, to quantitate the percentage of human cells that had been residing in the tissue of interest at the time of harvest. There is also a FACS|[ndash]|based assay to detect levels of the GUSB protein, and to allow sorting of donor-derived cells from any tissue after transplantation. The aspect of the NOD/SCID/GUSB null strain that makes it so particularly well suited for the study of human stem cell therapy is the clear-cut enzymatic stain for normal, GUSB positive human cells transplanted into the mice. On tissue slides prepared from mice that had been transplanted at birth with human mesenchymal stem cells, the histochemical stain for GUSB revealed normal cells in multiple tissues. Almost all tissues surveyed (N=19) demonstrated the presence of human MSC by staining for GUSB. The stain is quite specific, and although the released enzyme can be taken up by neighboring cells, it appears to be in very low abundance or, more likely, in a processed form where it is no longer detectable by the histochemical analysis. Thus, the individual transplanted human cells stand out vividly against the background murine tissues. In summary, the use of the NOD/SCID/MPSVII neonatal injection model has allowed accurate tracking and quantitation of human MSC into multiple tissues of mice injected by facial vein within three days of birth. This study may set the stage for neonatal gene/cell therapy for newborns with lysosomal storage diseases.
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations
Authors: Yukinori Okada, Michiaki Kubo, Hiroko Ohmiya, Atsushi Takahashi, Natsuhiko Kumasaka, Naoya Hosono, Shiro Maeda, Wanqing Wen, Rajkumar Dorajoo, Min Jin Go, Wei Zheng, Norihiro Kato, Jer-Yuarn Wu, Qi Lu, Tatsuhiko Tsunoda, Kazuhiko Yamamoto, Yusuke Nakamura, Naoyuki Kamatani, Toshihiro Tanaka
Journal: Nature Genetics (2012)