Adding<i>N</i>-acetylcysteine to prednisolone reduced early mortality in severe alcoholic hepatitis
Authors: Asma Siddique, Kris V. Kowdley
Journal: Annals of Internal Medicine (2012)

ACP Journal Club15 May 2012Adding N-acetylcysteine to prednisolone reduced early mortality in severe alcoholic hepatitisMarshall E. McCabe IV, Medical Student, 4th year, Asma Siddique, MD, Kris V. Kowdley, MD, FACPMarshall E. McCabe IV, Medical Student, 4th yearLiver Center of Excellence, Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington, USA (M.E.M., A.S., K.V.K.)Search for more papers by this author, Asma Siddique, MDLiver Center of Excellence, Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington, USA (M.E.M., A.S., K.V.K.)Search for more papers by this author, Kris V. Kowdley, MD, FACPLiver Center of Excellence, Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington, USA (M.E.M., A.S., K.V.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-10-201205150-02005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationNguyen-Khac E, Thevenot T, Piquet MA, et al; AAH-NAC Study Group. Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis. N Engl J Med. 2011;365:1781-9. https://pubmed.ncbi.nlm.nih.gov/22070475Clinical Impact RatingsHospitalists: Gastroenterology: References1 Lucey MR, Mathurin P, Morgan TR. Alcoholic hepatitis. N Engl J Med. 2009;360:2758-69. [PMID: 19553649] Google Scholar2 Christensen E, Gluud C. Glucocorticoids are ineffective in alcoholic hepatitis: a meta-analysis adjusting for confounding variables. Gut. 1995;37:113-8. [PMID: 7672658] Google Scholar3 Mathurin P, O’Grady J, Carithers RL, et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut. 2011;60:255-60. [PMID: 20940288] Google Scholar4 Farfán Labonne BE, Gutiérrez M, Gómez-Quiroz LE, et al. Acetaldehyde-induced mitochondrial dysfunction sensitizes hepatocytes to oxidative damage. Cell Biol Toxicol. 2009;25:599-609. [PMID: 19137438] Google Scholar5 Moreno C, Langlet P, Hittelet A, et al. Enteral nutrition with or without N-acetylcysteine in the treatment of severe acute alcoholic hepatitis: a randomized multicenter controlled trial. J Hepatol. 2010;53:1117-22. [PMID: 20801542] Google Scholar6 Stewart S, Prince M, Bassendine M, et al. A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. J Hepatol. 2007;47:277-83. [PMID: 17532088] Google Scholar Author, Article, and Disclosure InformationAuthors: Marshall E. McCabe IV, Medical Student, 4th year; Asma Siddique, MD; Kris V. Kowdley, MD, FACPAffiliations: Liver Center of Excellence, Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington, USA (M.E.M., A.S., K.V.K.)This article was published at Annals.org on 1 May 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 2012Volume 156, Issue 10Page: JC5-5KeywordsAlcoholicsBacterial diseasesGlucoseHepatitisHepatorenal syndromeInfectious hepatitisMortalityPulmonary diseasesSteroidsUpper respiratory tract infections ePublished: 15 May 2012 Issue Published: 15 May 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...