tbuckley/cabot-search huggingface dataset:
THE HEREDITARY TRANSMISSION OF HEMOGLOBIN DIFFERENCES IN MICE 1
Authors: Salome Gluecksohn-Waelsch, Helen M. Ranney, Betty F. Sisken
Journal: Journal of Clinical Investigation (1957)

The existence, in inbred strains of mice, of two different types of electrophoretic hemoglobin patterns has been demonstrated with the method of paper electrophoresis (1). Preliminary studies of the distribution of these different patterns in the inbred strains tested indicated strongly a genetic basis of hemoglobin differences in mice. It is the purpose of the present communication to report the results of breeding experiments designed to test the assumption of a hereditary transmission of these differences and to determine the mode of inheritance.
Frequencies of the major subgroups of precursor B-cell acute lymphoblastic leukemia in Indian children differ from the West
Authors: A K Siraj, S Kamat, M I Gutiérrez, S Banavali, G Timpson, S Sazawal, M Bhargava, S Advani, M Adde, I Magrath, K Bhatia
Journal: Leukemia (2003)
THE USE OF DUAL ANTIPLATELET THERAPY AND PATIENT OUTCOMES IN THOSE UNDERGOING PCI IN THE ROCKET AF TRIAL
Authors: Matthew W. Sherwood, Schuyler Jones, Derek Cyr, Richard Becker, Scott Berkowitz, Jeffrey Washam, Guenter Breithardt, Keith Fox, Jonathan Halperin, Graeme Hankey, Daniel Singer, Jonathan Piccini, Christopher Nessel, Kenneth Mahaffey, Robert Califf, Werner Hacke, Manesh Patel
Journal: Journal of the American College of Cardiology (2014)
Azotaemia Aggravated by Tetracycline
Authors: O. M. Edwards, E. C. Huskisson, R. T. Taylor
Journal: BMJ (1970)

Oxytetracycline given to two patients with impaired renal function produced clinical deterioration and increasing azotaemia. Both patients improved when oxytetracycline was stopped. In general tetracycline should not be used in patients with poor renal function, but if it is necessary the blood urea level should be checked frequently.
Bidirectional Modulation of Incubation of Cocaine Craving by Silent Synapse-Based Remodeling of Prefrontal Cortex to Accumbens Projections
Authors: Yao-Ying Ma, Brian R. Lee, Xiusong Wang, Changyong Guo, Lei Liu, Ranji Cui, Yan Lan, Judith J. Balcita-Pedicino, Marina E. Wolf, Susan R. Sesack, Yavin Shaham, Oliver M. Schlüter, Yanhua H. Huang, Yan Dong
Journal: Neuron (2014)
The GMC is too lenient
Authors: P. Wilmshurst
Journal: BMJ (2002)

Doctors complain that the General Medical Council (GMC) does little but strike their colleagues off the medical register. Members of the general public believe that the GMC is too lenient on doctors. These apparently incompatible views are both correct. When a complaint is made against a doctor the main consideration of the GMC is whether the complaint raises issues about conduct or performance that call into question the doctor's right to practise. The GMC lacks powers to consider misconduct or poor performance by a doctor unless it is sufficiently serious to be called “serious professional misconduct” or “seriously deficient performance.” Therefore the only cases considered by the GMC are ones where there is a strong possibility that the doctor will be removed from the medical register if charges are proved. As a result many allegations about doctors that the public considers serious are dismissed by the GMC at the screening stage. I believe that there is inappropriate rejection of serious allegations by lenient screeners.

There …
Combined C-11 Methionine and F-18 FDG PET Imaging in a Case of Neurosarcoidosis
Authors: David Ng, Martin Jacobs, Joseph Mantil
Journal: Clinical Nuclear Medicine (2006)

Purpose: PET scanning of the brain with F-18 FDG and C-11 methionine (MET) is useful for characterizing brain lesions discovered at MRI or CT. Most positive PET scans indicate malignancy. However, this case report demonstrates positive F-18 FDG and C-11 MET PET scans in a patient with a nonmalignant condition, neurosarcoidosis. Materials and Methods: We detail the history and evaluation of a 59-year-old woman who presented with ataxia. The patient's evaluation included a contrast-enhanced MRI followed by PET scanning of the brain with C-11 MET and of the brain and trunk with F-18 FDG. The patient subsequently underwent biopsy of a lesion as directed by MRI and PET. Results: The MRI demonstrated multiple enhancing leptomeningeal lesions consistent with metastatic disease. PET with F-18 FDG and C-11 MET demonstrated lesions in both cerebellar hemispheres with F-18 FDG accumulation in the mediastinum and left hilum. Biopsy of a brain lesion directed by MRI and PET revealed sarcoidosis. Conclusions: In evaluating brain lesions, PET with F-18 FDG and C-11 MET can help localize the lesion best suited for biopsy. However, not all lesions that have increased uptake on C-11 MET or F-18 FDG PET are malignant. Granulomatous inflammatory diseases such as neurosarcoidosis should also be considered in the differential diagnosis.
Comparison of Tc-99m HMPAO Fast SPECT with Tc-99m HMPAO Conventional SPECT in Patients with Acute Stroke
Authors: MOTOO OSHIMA, MASANORI TADOKORO, SADAYUKI SAKUMA
Journal: Clinical Nuclear Medicine (1992)

Tc-99m HMPAO SPECT is more likely to detect a stroke in early stages than CT. However, a conventional HMPAO SPECT study takes at least 30 minutes to complete. This paper compares fast Tc-99m HMPAO SPECT scans and conventional Tc-99m HMPAO SPECT scans with respect to spatial resolution and diagnostic efficacy in vitro and in a small series of patients, respectively. The spatial resolution of fast Tc-99m HMPAO SPECT did not match that of images obtained from conventional SPECT, though the difference proved to be of no clinical significance. Since fast SPECT requires only one-fourth to one-fifth the time necessary for conventional SPECT, it may be more suitable for investigating cases of acute stroke in critical clinical situations.
Clinical Experience with Guanethidine in the Treatment of Hypertension
Authors: John J. Kelly
Journal: JAMA (1961)

IN RECENT YEARS, numerous drugs have been introduced for the reduction of blood pressure in severe hypertension. The most potent of these, the ganglionic blocking agents, have been limited in usefulness because of the side-effects associated with parasympathetic blockade. 1 This report is a clinical evaluation of guanethidine (Ismelin), a new antihypertensive agent. Synthesized by Mull and associates, guanethidine, 2 (octohydro 1 azocinyl) ethyl guanidine sulfate, has an 8-member ring which differs radically from the structure of the ganglionic blocking drugs. The evidence from animal work 2 indicates that guanethidine is a potent hypotensive agent which does not interfere with ganglionic transmission and produces sympathetic blockade at a lower level by preventing release or inactivating the pressor substance at the sympathetic end-plate.  Methods and Materials  To evaluate the drug's action in man, we selected a group of 16 severe hypertensive patients, with a history of 3 to 20 years' duration.
High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation
Authors: Doris M. Ponce, Patrick Hilden, Christen Mumaw, Sean M. Devlin, Marissa Lubin, Sergio Giralt, Jenna D. Goldberg, Alan Hanash, Katharine Hsu, Robert Jenq, Miguel-Angel Perales, Craig Sauter, Marcel R. M. van den Brink, James W. Young, Renier Brentjens, Nancy A. Kernan, Susan E. Prockop, Richard J. O’Reilly, Andromachi Scaradavou, Sophie Paczesny, Juliet N. Barker
Journal: Blood (2014)
Abstract P4-10-12: Wire Guided Breast Procedures with Intraoperative Ultrasound
Authors: IK Komenaka, ME Bouton, KL. Wilhelmson
Journal: Cancer Research (2010)

Abstract Background: Wire guided breast procedures (WGBP) are the most commonly used breast conserving operation for non-palpable cancers. Suboptimal needle placement can result in a larger amount of tissue removed and increased difficulty in removal of the lesion. The use of intraoperative ultrasound can improve the execution of wire guided breast procedures by more precisely demonstrating the direction and depth of the wire as well as the location of the wire hook and radiographic clip. These benefits allow a more appropriately located incision and smaller volume of tissue removed. Methods: A retrospective review of all patients who underwent the WGBP at a county hospital with associated surgical residency program. 28 patients underwent the procedure with intraoperative ultrasound from June 2009 to March 2010. Results: Breast cancer patients who underwent a wire-guided lumpectomy with intraoperative ultrasound had a lower rate of positive margins (9% vs. 26%, p = 0.28) and a smaller volume of tissue removed (126 cm3 vs. 146 cm3, p = 0.57) compared to patients who underwent wire guided lumpectomy alone. In patients who underwent wire guided excisional biopsy for diagnostic purposes, the volume of tissue removed was smaller in the intraoperative ultrasound group (30 cm3 vs. 44 cm3, p = 0.17) and the targeted area was more likely to be removed in one specimen (1.1 vs. 1.5, p = 0.03) compared to those who underwent the procedure without intraoperative ultrasound. Two illustrative cases with figures are presented. The first demonstrates the benefit when the distance from skin entry point of the wire to the target area is great. The hook can be localized with ultrasound for optimal placement of the incision. The second demonstrates potential benefit when wire placement is suboptimal and the wire hook is distant from the target. The surgeon may use the wire location to identify the approximate area of the lesion and then the exact location of the radiographic clip can be localized with intraoperative ultrasound. Conclusions: Intraoperative ultrasound can improve surgical outcomes of the wire guided breast procedure. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P4-10-12.
TCT-824 The impact of creation of a transcatheter aortic valve program on surgical aortic valve replacement (sAVR) volume and outcomes: A single center experience
Authors: Firas Zahr, William Anderson, Thomas Gleason, Forozan Navid, Lisa Henry, Suresh Mulukutla, William Katz, Frederick Crock, Joon Lee, John Schindler
Journal: Journal of the American College of Cardiology (2012)
Restoring Visual Function to Blind Mice with a Photoswitch that Exploits Electrophysiological Remodeling of Retinal Ganglion Cells
Authors: Ivan Tochitsky, Aleksandra Polosukhina, Vadim E. Degtyar, Nicholas Gallerani, Caleb M. Smith, Aaron Friedman, Russell N. Van Gelder, Dirk Trauner, Daniela Kaufer, Richard H. Kramer
Journal: Neuron (2014)
More pubs will escape smoking ban than UK government has claimed
Authors: Zosia Kmietowicz
Journal: BMJ (2005)

The number of pubs in England that will be exempt from the government's proposed law on banning smoking because they do not serve food is far higher than previously estimated, a short survey conducted by the BMA indicates.

Nearly nine out of 10 (88%) of the pubs in Leeds do not serve food, estimates the city council. This is three times the government's top estimate of the number of pubs in all areas that will continue to allow smoking when the law is introduced in 2008.

Leeds City Council was one of 29 metropolitan, city, and London …
Repetitive Weekly Cycles of Recombinant Human Interleukin-2: Responses of Renal Carcinoma With Acceptable Toxicity1
Authors: J. A. Sosman, P. C. Kohler, J. Hank, K. H. Moore, R. Bechhofer, B. Storer, P. M. Sondel
Journal: JNCI Journal of the National Cancer Institute (1988)

A phase I trial of repetitive weekly cycles of human recombinant interleukin-2 (IL-2) was performed in 23 patients with metastatic carcinoma. Patients received 4 days of IL-2 each week, followed by 3 days of observation, for 4 consecutive weeks. IL-2 was administered iv at 1.0 or 3.0 × 106 U/m2/day by one of three schedules involving continuous or bolus infusions. All treatment was carried out in a general hospital ward without intensive care unit monitoring or support. Seventeen patients had metastatic renal cell carcinoma; three of these demonstrated measurable (>50% shrinkage) partial responses. This study demonstrates that IL-2 given alone without lymphokine-activated killer cells in this manner can induce antitumor effects with acceptable toxicity. [J Natl Cancer Inst 1988;80:60-63]
Mental health law: College committed to improving training
Authors: F Caldicott, S Mann, I C C Matheson, M J Leverton, P A Patchett, P Sugarman, J Moss, D Silberston, S P Robinson
Journal: BMJ (1994)

<h3>Objective</h3> To systematically review and evaluate the available evidence supporting or refuting clinical use of therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) in patients with epilepsy. <h3>Methods</h3> We searched MEDLINE, Embase, BIOSIS, Cochrane, PubMed, Africa-Wide Information, Web of Science, and grey literature. Randomized controlled studies and observational studies that compared the clinical outcomes of TDM vs non-TDM were included. Two reviewers independently extracted the data. The primary outcome was seizure control; adverse effects were considered as secondary outcomes. The PROSPERO ID of this systematic review9s protocol is CRD42018089925. <h3>Results</h3> Sixteen studies were identified meeting eligibility requirements. Four randomized controlled trials (RCTs), 1 meta-analysis, and 11 quasiexperimental (QE) studies were included in the systematic review. Results from the analysis of RCTs showed no significant positive effect of TDM on seizure outcome (only 25% positive effect of phenytoin). However, some of the QE studies found that TDM was associated with better seizure control or lower rates of adverse effects. The existing evidence from various designs has shown various methodological implications, which warrants inconclusive results and highlights the requirement of more number of studies in this line. <h3>Conclusions</h3> If optimally implemented, TDM may enhance clinical care, particularly for phenytoin and other AEDs with complex pharmacokinetics. However, the ideal method for implementation is unclear, and serum drug levels should be considered in context with patient-reported clinical data regarding seizure control and adverse events.
Ulcer Symptoms Associated With an Unusual Abdominal Mass
Authors: Donald L. Stone
Journal: JAMA (1965)

Dr. Dale E. Wenlund: A 26-year-old man had been healthy until two years ago when midepigastric pain and vomiting without nausea developed. Vomiting occurred after eating and pain occurred when the stomach was empty, especially at night. At that time an upper gastrointestinal series was performed at another hospital; he was told that he had a bleeding duodenal ulcer. He was treated for an ulcer but continued to have difficulty with vomiting and pain. Over the next two years he lost a considerable amount of weight. He was able to eat only soft foods such as custards and soups, because solid foods caused vomiting.  Two weeks prior to admission another gastrointestinal series was done, and again he was told that he had a duodenal ulcer.  Physical examination revealed normal vital signs; he appeared to be ill and considerably older than his stated age. His abdomen was somewhat protuberant and quite
Anemia Due to Copper Deficiency.
Authors: William M. Dunlap
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Anemia Due to Copper Deficiency.William M. Dunlap, M.D., G. Watson James III, M.D., F.A.C.P., David M. Hume, M.D.William M. Dunlap, M.D.Search for more papers by this author, G. Watson James III, M.D., F.A.C.P.Search for more papers by this author, David M. Hume, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-825_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA patient with anemia secondary to copper deficiency is described. She had a superior mesenteric artery thrombosis with necrosis of the ascending colon and small intestine, requiring resection of these areas and duodenocolic anastomosis in January 1971, 18 months before her anemia became apparent. Because of inability to tolerate oral feedings, she had to be maintained on intravenous hyperalimentation indefinitely with vitamin supplements. When evaluated in June 1972, with hemoglobin of 9.4 g/100 ml, she had negative physical findings. Her leukocyte count was 3000/ mm3(70% lymphocytes); reticulocyte count, 1%, and platelets, 300 000/mm3. Erythrocyte morphology showed spherocytes, macrocytes, and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Richmond, Virginia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 825-825KeywordsAnemiaColonHemoglobinLymphocytesMesenteric arteriesNecrosisPlateletsReticulocytesSmall intestineThrombosis Issue Published: 1 May 1973 PDF DownloadLoading ...
The relationship between serum IgE and surface levels of FcϵR on human leukocytes in various diseases: Correlation of expression with FcϵRI on basophils but not on monocytes or eosinophils
Authors: Sarbjit S. Saini, Amy D. Klion, Steven M. Holland, Robert G. Hamilton, Bruce S. Bochner, Donald W. MacGlashan
Journal: Journal of Allergy and Clinical Immunology (2000)
764-1 Dobutamine Transesophageal Echo in the Assessment of Coronary Artery Disease: Comparison with Dobutamine Transthoracic Echo in the Same Setting
Authors: Magdy Ismaeil, Theodor Trusevich, Shashikumar Bellur, Sheri Y. Nottestad, R. Stefan Kiesz, Fathy Maklady, Miguel Zabalgoitia
Journal: Journal of the American College of Cardiology (1995)
Low dose radiosensitivity of alloimmune cytotoxic T cells.
Authors: C Spellman, R E Anderson
Journal: The Journal of Experimental Medicine (1982)

Low dose radiosensitivity of in vitro generated alloimmune murine cytotoxic T lymphocytes (CTL) was studied. It appears that a subset of CTL exists that can be killed with 10-25 rad of x rays. These radiosensitive CTL are Lyt-1,2+ T lymphocytes. Analyses of cytotoxicity by chromium release assays indicate that the radiosensitive CTL are present in responder spleen cell cultures from all strains of mice tested. The generation of these effector cells is most pronounced in animals of the C57BL background. The mechanism of low dose radiosensitivity appears to be interphase death.
A Policeman's Lot Is Not a Happy One: Flak Jacket Radiculopathy
Authors: Leslie S. Rachlin
Journal: JAMA (1987)

<h3>To the Editor.—</h3> TheThe practice of medicine often presents us with unusual and exotic diagnostic dilemmas. Such cases generally reaffirm my belief that a good physician is as much sleuth as scientist. <h3>Report of a Case.—</h3> On June 16, 1986, a 42-year-old male police officer complained of bilateral upper-extremity numbness that traveled the length of his arms and was exacerbated by reaching or stretching. The symptoms were greatest on the medial aspect of both arms and hands. He denied any other neurological or musculoskeletal symptoms. He also denied recent trauma to the neck, shoulders, or arms. He had not engaged in any recent heavy-caliber rifle or pistol practive, nor had he engaged in significant physical activity recently. His job consisted mainly of daily patrol in his squad car. Results of the examination of his neck and upper extremities were within normal limits. Roentgenograms of his cervical spine were unremarkable. His
Bronchodilator effect of sodium cromoglycate and its clinical implications.
Authors: J T Chung, R S Jones
Journal: BMJ (1979)

The bronchodilator effect of sodium cromoglycate (SCG) solution was investigated. Twenty asthmatic children aged 6-15 years (mean 11.3) were examined and the action of SCG compared with that of salbutamol and placebo (water). SCG produced a significantly raised peak expiratory flow rate (PEFR) before exercise, which reached a maximum immediately after exercise. The bronchodilatation was sustained for up to four hours, when the PEFR was still significantly above the resting value. This effect was comparable in degree and duration with that of salbutamol. In contrast, placebo produced insignificant bronchodilatation before exercise but significant albeit short-lived bronchodilatation after exercise, which is the characteristic response of the asthmatic to a short period of exercise. This powerful bronchodilator action of SCG and its equally potent inhibitory action on exercise-induced bronchoconstriction was achieved by administering the solution via an efficient nebuliser. In order to achieve maximum clinical effect the SCG must, therefore, be given in this form.
Immediate results and late outcomes after stent implantation in saphenous vein graft lesions: The multicenter U.S. Palmaz-Schatz stent experience
Authors: S. Chiu Wong, Donald S. Baim, Richard A. Schatz, Paul S. Teirstein, Spencer B. King, R. Charles Curry, Richard R. Heuser, Stephen G. Ellis, Michael W. Cleman, Paul Overlie, John W. Hirshfeld, Craig M. Walker, Frank Litvack, David Fish, Jeffrey A. Brinker, Maurice Buchbinder, Sheldon Goldberg, None Ya Chien Chuang, Martin B. Leon
Journal: Journal of the American College of Cardiology (1995)

This study reports the multicenter registry experience evaluating the safety and efficacy of the Palmaz-Schatz stent in the treatment of saphenous vein graft disease. Saphenous vein graft angioplasty is associated with frequent periprocedural complications and a high frequency of restenosis. Stent implantation has been shown to reduce restenosis, with improved long-term outcomes in the treatment of native coronary artery disease. Preliminary experience with stent placement in the treatment of saphenous vein graft lesions has been favorable. Twenty U.S. investigator sites enrolled a total of 589 symptomatic patients (624 lesions) for treatment of focal vein graft stenoses between January 1990 and April 1992. Follow-up angiography was performed at 6 months, and the clinical course of all study patients was prospectively collected at regular intervals for up to 12 months. Stent delivery was successful in 98.8% of cases, and the procedural success rate was 97.1%. The lesion diameter stenosis decreased from 82 ± 12% (mean ± SD) before to 6.6 ± 10.2% after treatment. Major in-hospital complications occurred in 17 patients (2.9%); stent thrombosis was found in 8 (1.4%); and major vascular or bleeding complications were noted in 83 (14.3%). Six-month angiographic follow-up revealed an overall restenosis rate (≥50% diameter stenosis) of 29.7%. Multivariate logistic regression analysis indicated that 1) restenotic lesions, 2) smaller reference vessel size, 3) history of diabetes mellitus, and 4) higher percent poststent diameter stenosis were independent predictors of restenosis. The 12-month actuarial event-free survival was 76.3%. Stent implantation in patients with focal saphenous vein graft lesions can be achieved with a high rate of procedural success, acceptable major complications, reduced angiographic restenosis and favorable late clinical outcome compared with historical balloon angioplasty control series. The rigorous anticoagulation regimen after stent placement results in more frequent vascular and other bleeding complications. Future randomized studies comparing standard balloon angioplasty with stent implantation are warranted to properly assess the full impact of stent placement in the treatment of saphenous vein graft lesions.
Idiosyncratic dapsone induced manic depression.
Authors: A. J. Carmichael, C. J. Paul
Journal: BMJ (1989)

charged from hospital but readmitted 24 hours later with relapse.The rash was more severe, exfoliative, and superficially pustular, and her fever became undulant.Investigation showed a mild anaemia (haemoglobin 114 g/l), a very high leucocyte count (22 6x 109, 52% neutrophils), and abnormal liver function values (y-glutamyltransferase 417 IU/1, aspartate transaminase 182 IU/1, and alkaline phosphatase 560 IU/l hepatic iso-