tbuckley/cabot-search huggingface dataset:
Gait Analysis: Normal and Pathological Function
Authors: Jacquelin Perry, Judith M. Burnfield
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Slow-Release Lanreotide Treatment in Acromegaly: Effects on Quality of Life
Authors: N. Sonino, E. Scarpa, A. Paoletta, F. Fallo, M. Boscaro
Journal: Psychotherapy and Psychosomatics (1999)

It is not known whether medical treatment to lower growth hormone (GH) and insulin-like growth factor (IGF)-1 levels may improve the compromised quality of life of patients with acromegaly.We studied the effects on quality of life of the slow-release somatostatin analogue lanreotide, 30 mg i.m., every 14 days for 2 months in 10 patients with active acromegaly (8 females/2 males, mean age 57.3 +/- 11.4). Hormone measurements and psychometric evaluation by means of self-rating scales were carried out in baseline conditions and after 1 and 2 months. The Symptom Questionnaire (SQ), the Cognitive Scale of the Screening List for Psychosocial Problems by Kellner and the Social Situation Questionnaire by Marks were employed.Together with a significant decrease in GH and IGF-1, treatment with lanreotide significantly improved SQ psychological distress, SQ well-being and Social Situation Questionnaire social fears.Medical treatment with lanreotide may improve the quality of life of patients with acromegaly. Being an open trial, changes could be due to nonspecific effects. However, they did not fade at 2 months. Improvement involved fears of social situations that have been linked to GH abnormalities.
Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.
Authors: W P Fung-Leung, J De Sousa-Hitzler, A Ishaque, L Zhou, J Pang, K Ngo, J A Panakos, E Chourmouzis, F T Liu, C Y Lau
Journal: The Journal of Experimental Medicine (1996)

The high-affinity receptor for immunoglobulin (Ig) E (Fc epsilon RI) on mast cells and basophils plays a key role in IgE-mediated allergies. Fc epsilon RI is composed of one alpha, one beta, and two gamma chains, which are all required for cell surface expression of Fc epsilon RI, but only the alpha chain is involved in the binding to IgE. Fc epsilon RI-IgE interaction is highly species specific, and rodent Fc epsilon RI does not bind human IgE. To obtain a "humanized" animal model that responds to human IgE in allergic reactions, transgenic mice expressing the human Fc epsilon RI alpha chain were generated. The human Fc epsilon RI alpha chain gene with a 1.3-kb promoter region as a transgene was found to be sufficient for mast cell-specific transcription. Cell surface expression of the human Fc epsilon RI alpha chain was indicated by the specific binding of human IgE to mast cells from transgenic mice in flow cytometric analyses. Expression of the transgenic Fc epsilon RI on bone marrow-derived mast cells was 4.7 x 10(4)/cell, and the human IgE-binding affinity was Kd = 6.4 nM in receptor-binding studies using 125I-IgE. The transgenic human Fc epsilon RI alpha chain was complexed with the mouse beta and gamma chains in immunoprecipitation studies. Cross-linking of the transgenic Fc epsilon RI with human IgE and antigens led to mast cell activation as indicated by enhanced tyrosine phosphorylation of the Fc epsilon RI beta and gamma chains and other cellular proteins. Mast cell degranulation in transgenic mice could be triggered by human IgE and antigens, as demonstrated by beta-hexosaminidase release in vitro and passive cutaneous anaphylaxis in vivo. The results demonstrate that the human Fc epsilon RI alpha chain alone not only confers the specificity in human IgE binding, but also can reconstitute a functional receptor by coupling with the mouse beta and gamma chains to trigger mast cell activation and degranulation in a whole animal system. These transgenic mice "humanized" in IgE-mediated allergies may be valuable for development of therapeutic agents that target the binding of IgE to its receptor.
Abstract 5253: PTEN represses oncogene expression by regulating Daxx-H3.3 deposition in the chromatin
Authors: Jorge A. Benitez, Webster K. Cavenee, Frank F. Furnari
Journal: Cancer Research (2014)

Abstract One of the most mutated and deleted gene in cancer is the tumor suppressor gene pten (phosphatase and tensin homology, deleted on chromosome ten). To further understand how PTEN inactivation contributes to cancer predisposition, we investigated how PTEN regulates gene expression. We found that the histone chaperon protein Daxx (death domain-associated protein) associates with PTEN, in vivo and in vitro, and regulates PTEN stability through acetylation and ubiquitination. We observed that PTEN regulates Histone 3.3 (H3.3 variant) loading in the chromatin by limiting Daxx interactions, and thereby controls expression of several tumor driver genes. Furthermore, when Daxx expression is disrupted in pten-deficient glioma stem cells, we observed a dramatic diminution of pluripotency transcription factors, a decrease in differentiation and sphere-forming capacity, and an increase in radiation sensitivity. In conclusion, this work supports a novel chromatin-associated function for PTEN that regulates H3.3 deposition, and gene expression, through Daxx interaction. This nominates Daxx as a therapeutic target to treat patients with gliomas and other types of cancers in which PTEN is mutated. Citation Format: Jorge A. Benitez, Webster K. Cavenee, Frank F. Furnari. PTEN represses oncogene expression by regulating Daxx-H3.3 deposition in the chromatin. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5253. doi:10.1158/1538-7445.AM2014-5253
Outcomes of Lyme Disease
Authors: Nancy A. Shadick
Journal: Annals of Internal Medicine (2000)

Letters7 November 2000Outcomes of Lyme DiseaseNancy A. Shadick, MD, MPH, Robert A. Lew, PhD, and Matthew H. Liang, MD, MPHNancy A. Shadick, MD, MPHBrigham and Women's Hospital; Boston, MA 02115 (Shadick, Lew, Liang)Search for more papers by this author, Robert A. Lew, PhDBrigham and Women's Hospital; Boston, MA 02115 (Shadick, Lew, Liang)Search for more papers by this author, and Matthew H. Liang, MD, MPHBrigham and Women's Hospital; Boston, MA 02115 (Shadick, Lew, Liang)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-9-200011070-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Prybylski's insights. He interprets the findings as we do but arrives at them by way of a different path. We agree that it is striking that 14 self-reported symptoms were more prevalent in patients with previous Lyme disease than in those without. Among the 26 symptoms about which patients were queried, we chose these 14 symptoms to highlight in tabular form because they were more prevalent. We similarly noted the striking deficits in health-related quality of life, as measured by the SF-36, among patients with Lyme disease and believe this to be one of the ...References1. Kaplan RF, Meadows ME, Vincent LC, Logigian EL, Steere AC. Memory impairment and depression in patients with Lyme encephalopathy: comparison with fibromyalgia and nonpsychotically depressed patients. Neurology. 1992;42:1263-7. CrossrefMedlineGoogle Scholar2. Selvin S. Statistical Analysis of Epidemiologic Data. New York: Oxford Univ Pr; 1991. Google Scholar3. Mosteller F, Tukey J. Data Analysis and Regression. Reading, MA: Addison-Wesley; 1977. Google Scholar Author, Article, and Disclosure InformationAuthors: Nancy A. Shadick, MD, MPH; Robert A. Lew, PhD; Matthew H. Liang, MD, MPHAffiliations: Brigham and Women's Hospital; Boston, MA 02115 (Shadick, Lew, Liang) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMusculoskeletal and Neurologic Outcomes in Patients with Previously Treated Lyme Disease Nancy A. Shadick , Charlotte B. Phillips , Oliver Sangha , Eric L. Logigian , Richard F. Kaplan , Elizabeth A. Wright , Anne H. Fossel , Karin Fossel , Victor Berardi , Robert A. Lew , and Matthew H. Liang Outcomes of Lyme Disease Dimitri Prybylski Metrics 7 November 2000Volume 133, Issue 9Page: 746-747KeywordsArthralgiaBrainBrain diseasesFactor analysisForecastingKneesLyme diseaseMedical risk factorsPsychometricsQuality of life ePublished: 7 November 2000 Issue Published: 7 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Efficacy of 100 mg of double-bolus alteplase in achieving complete perfusion in the treatment of acute myocardial infarction
Authors: John A. Purvis, Albert J. McNeill, Rizwan A. Siddiqui, Michael J.D. Roberts, Brian M. McClements, David McEneaney, Norman P.S. Campbell, Mazhar M. Khan, Sam W. Webb, Carol M. Wilson, A.A.Jennifer Adgey
Journal: Journal of the American College of Cardiology (1994)
1994 Year in Review: selected topics in respiratory medicine
Authors: S. G Spiro
Journal: Thorax (1995)

1994 Year in Review: selected topics in respiratory medicine Critical appraisals of advances, new ideas, or new diseases in respiratory medicine have always proved popular.Conference halls have always been full when clinical reviews are proffered by authorities in their field.With this month's edition of Thorax the first of a series of selected topics from the previous year appear.The three editors -David Hendrick, Charles Hind, and Neil Pride -were asked to each choose four areas in which, in their opinion, an important manuscript or manuscripts were published in a peer reviewed medical journal.
Postreplicative Joining of DNA Double-Strand Breaks Causes Genomic Instability in DNA-PKcs–Deficient Mouse Embryonic Fibroblasts
Authors: Marta Martín, Anna Genescà, Laura Latre, Isabel Jaco, Guillermo E. Taccioli, Josep Egozcue, María A. Blasco, George Iliakis, Laura Tusell
Journal: Cancer Research (2005)

Abstract Combined cytogenetic and biochemical approaches were used to investigate the contributions of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) in the maintenance of genomic stability in nonirradiated and irradiated primary mouse embryo fibroblasts (MEF). We show that telomere dysfunction contributes only marginally to genomic instability associated with DNA-PKcs deficiency in the absence of radiation. Following exposure to ionizing radiation, DNA-PKcs−/− MEFs are radiosensitized mainly as a result of the associated DNA double-strand break (DSB) repair defect. This defect manifests as an increase in the fraction of DSB rejoining with slow kinetics although nearly complete rejoining is achieved within 48 hours. Fifty-four hours after ionizing radiation, DNA-PKcs−/− cells present with a high number of simple and complex chromosome rearrangements as well as with unrepaired chromosome breaks. Overall, induction of chromosome aberrations is 6-fold higher in DNA-PKcs−/− MEFs than in their wild-type counterparts. Spectral karyotyping-fluorescence in situ hybridization technology distinguishes between rearrangements formed by prereplicative and postreplicative DSB rejoining and identifies sister chromatid fusion as a significant source of genomic instability and radiation sensitivity in DNA-PKcs−/− MEFs. Because DNA-PKcs−/− MEFs show a strong G1 checkpoint response after ionizing radiation, we propose that the delayed rejoining of DNA DSBs in DNA-PKcs−/− MEFs prolongs the mean life of broken chromosome ends and increases the probability of incorrect joining. The preponderance of sister chromatid fusion as a product of incorrect joining points to a possible defect in S-phase arrest and emphasizes proximity in these misrepair events.
Why general practitioners and consultants change their clinical practice: a critical incident study
Authors: L. A Allery, P. A Owen, M. R Robling
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To describe the complete range of factors which doctors recognise as changing their clinical practice and provide a measure of how often education is involved in change. <b>Design:</b> Interviews using the critical incident technique. <b>Setting:</b> Primary and secondary care. <b>Subjects:</b> Random sample of 50 general practitioners and 50 consultants. <b>Main outcome measures:</b> Categories of reasons for change in clinical practice. <b>Results:</b> Doctors described 361 changes in clinical practice, with an average of 3.0 reasons per change. The three most frequently mentioned reasons were organisational factors, education, and contact with professionals, together accounting for 47.9% of the total number of reasons for change. Education accounted for one sixth (16.9%) of the reasons for change and was involved in one third (37.1%) of the changes. Education was seldom mentioned as a reason for change in referral practice but was more often mentioned in management and prescribing changes. Consultants were influenced by medical journals and scientific conferences, while general practitioners were more influenced by medical newspapers and postgraduate meetings. <b>Conclusions:</b> Education is involved in about a third of changes in clinical practice. The wide range of other factors affecting changes in practice need to be taken into account in providing and evaluating education. The role of education in the numerous changes in clinical practice that currently have no educational component should also be considered. <h3>Key messages</h3> Limited information is available from quantitative studies to understand the relation between education and change in clinical practice Doctors recognise organisational factors, education, and contact with professionals as influential in changing their clinical practice In this study education provided one sixth of the reasons for change, and was involved in one third of the changes The average number of reasons per change was three The wide range of factors involved in changing practice need to be considered in the provision and evaluation of education as does the role of education in the majority of changes in clinical practice which currently have no educational component
Nelson's Surgeon: William Beatty, Naval Medicine, and the Battle of Trafalgar
Authors: Graeme Glass
Journal: BMJ (2005)

T he 200th anniversary this year of the Battle of Trafalgar has sparked new life into the subject of Britain's mari-time history. But the work of naval surgeons has rarely been explored in any great detail. Signing up for the navy was often seen as a route by which young men with an interest in surgery and a basic qualification provided by the Company of Surgeons could gain experience before furthering their career in private, civilian practice. For others it was the only opportunity to practise, their level of proficiency being …
Staphylococcal Hospital Infections
Authors: Murray N. Levin
Journal: New England Journal of Medicine (1957)

THE purpose of this communication is to report an outbreak of staphylococcal infections on the Surgical Service of the Veterans Administration Hospital, Manchester, New Hampshire, the measures taken to control these and prevent further infection, and the early results obtained. It will be seen that the probable solution of this problem depends upon the return to basic principles of rigid asepsis on the part of all concerned with handling the surgical patient.That an increased number of infections with antibiotic-resistant pyogenic micrococci in hospitalized patients is occurring commonly at present is obvious, and a large literature devoted to this subject . . .
Bismuth Preparations for Diarrhea-Reply
Authors: Charles D. Ericsson
Journal: JAMA (1980)

<h3>In Reply.—</h3> DrDr Kreusi is concerned about neuropsychiatric disease that might follow ingestion of certain bismuth-containing salts. MartinBouyer et al<sup>1</sup>have compiled a report of 698 cases with bismuth encephalopathy of which 618 had confirmed bismuthemia after ingestion of medication predominately containing bismuth subgallate. In 152 patients, bismuthemia was detected more than eight days after stopping bismuth salt ingestion. In our own study, blood specimens were obtained from six subjects within 24 hours of stopping treatment with subsalicylate bismuth (Pepto-Bismol) that had been ingested at a dosage of 226.7 g/day (8 oz) for three weeks. We have also collected blood specimens from four volunteers who took four equally spaced 56.7-g (2-oz) doses of PeptoBismol for 24 hours. Richard Caprioli (Department of Analytical Chemistry, University of Texas Medical School, Houston) used x-ray fluorescence spectrophotometry with a threshold sensitivity in the range of 50 μg/L and was unable to detect bismuth
Mass Intervention vs Screening and Selective Intervention for the Prevention of Coronary Heart Disease
Authors: Robert E. Olson
Journal: JAMA (1986)

IN THE April 12 issue of<i>JAMA</i>, the statement of the National Institutes of Health (NIH) Consensus Development Conference on "Lowering Blood Cholesterol to Prevent Heart Disease" was published<sup>1</sup>together with three related articles. The key recommendation of the consensus conference was that all individuals in this country beyond the age of 2 years should be advised to follow fat-modified diets in the interest of preventing coronary disease regardless of their sex, their age, or the presence of other risk factors. <h3>Report on Educational Initiative to Lower Lipid Levels</h3> The first related article<sup>2</sup>was a discourse on a national educational initiative to lower plasma lipid levels in the entire population by Drs William R. Harlan and Jeoffrey K. Stross. In agreeing with the Consensus Panel, these authors proposed that it is time now to launch a massive education program for professionals and the public regarding the benefits of
Low-dose chest computed tomography for quantitative and visual anatomical analysis in patients with acute respiratory distress syndrome
Authors: Davide Chiumello, Thomas Langer, Vittoria Vecchi, Simone Luoni, Andrea Colombo, Matteo Brioni, Sara Froio, Irene Cigada, Silvia Coppola, Alessandro Protti, Marco Lazzerini, Luciano Gattinoni
Journal: Intensive Care Medicine (2014)
TECHNIQUE OF VAGINAL EXTIRPATION FOR CANCER OF THE CERVIX BY LIGATURE ONLY
Authors: RUFUS B. HALL
Journal: JAMA (1900)

It would hardly seem necessary before this audience to emphasize the importance of careful preparation of the patient before subjecting her to such a serious operation as the one to be considered. Yet this is a very important element in the after-management and in bringing a case of hysterectomy for cancer to a successful termination. These patients should be as carefully prepared for the operation as though they were about to be subjected to an abdominal section. It is especially desirous that the function of the kidneys be carefully investigated in every instance and every defect noted and corrected if possible. It is always advantageous in this preliminary treatment to keep the patient under observation for a few days. The anesthetic selected should be chloroform in every instance, unless it is contraindicated from heart lesions, or, as is the case in rare instances, where the patient does not take the
THE RUHEMANN URICOMETER FOR URIC ACID ESTIMATION
Authors: H. C. Bradley
Journal: JAMA (1913)

A critical examination of the Ruhemann method for the clinical estimation of uric acid was undertaken in this laboratory, and the results may be of interest to clinicians. The urine of a single individual was examined for a period of forty days. The dietary was so arranged that the first estimations were made after a purin-free period and represent therefore the individual's endogenous uric acid excretion. There followed periods of mixed and vegetarian diets, with and without violent exercise, with and without excessive fluid ingested. The test concluded with a period of purin-rich diet, pushed to the extreme during the last twenty-four hours, so that the subject, attained the extraordinary excretion of 3 gm. per day. The accompanying chart represents the uricometer and by the standard method of Folin.
THE USE OF SN-10,275 IN THE PROPHYLAXIS AND TREATMENT OF SPOROZOITE-INDUCED VIV AX MALARIA (CHESSON STRAIN) 1
Authors: Theodore N. Pullman, Lillian Eichelberger, Alf S. Alving, Ralph Jones, Branch Craige, C. Merrill Whorton
Journal: Journal of Clinical Investigation (1948)

A large number of piperidyl quinolinemethanols were investigated for antimalarial activity in avian infections because of close chemical similarity to quinine, as part of the wartime search for new and more effective antimalarial agents.In preliminary observations, SN-10,275,3 or 6,8-dichloro-2- phenyl-a-2-piperidyl4-quinolinemethanol (Figure 1), gave greatest indication of promise.It is a compound of the Ainley-King series, which has a high degree of antimalarial activity in cathemerium and lophurae malaria in the duck and moderate ac- tivity in gallinaceum and lophurae malaria in the chick ( 1 ). PROCEDURES AND METHODSGeneral.Details of the general procedure and the plan of observations are reported elsewhere (2).Healthy
Decreased Left Atrial Appendage Velocity Does Not Predict Recurrence at Long-Term in Patients who Underwent Cryoballoon-Ablation for Atrial Fibrillation
Authors: Başar Candemir, Cansın T. Kaya, Mustafa Kılıçkap, Siamek Aghdam, Ali T. Altin, Aydan Ongun, Kutay Vurgun, Omer Akyurek, Muharrem Guldal, Cetin Erol
Journal: Journal of the American College of Cardiology (2013)
More doctors and donors needed for transplantation in the UK
Authors: Z. Kmietowicz
Journal: BMJ (1999)

More doctors and twice the number of donors are needed to avert a worsening crisis in transplant surgery, warned the Royal College of Surgeons last week.

Waiting lists for organ transplants are continuing to grow but the number of cadaver donors has remained at around 900 a year since 1990, according to the report by a two year working party into the state of transplant surgery in the United Kingdom. At any time, 4500 people are on a waiting list for a heart, liver, or lung transplant, and 1 in 5 …