Methysergide Therapy and Constrictive Pericarditis
Authors: Roy C. Orlando, Phillip Moyer, Thomas B. Barnett
Journal: Annals of Internal Medicine (1978)

Brief Reports1 February 1978Methysergide Therapy and Constrictive PericarditisROY C. ORLANDO, M.D., PHILLIP MOYER, M.D., THOMAS B. BARNETT, M.D., F.A.C.P.ROY C. ORLANDO, M.D.Search for more papers by this author, PHILLIP MOYER, M.D.Search for more papers by this author, THOMAS B. BARNETT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-2-213 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMethysergide is an ergot alkaloid useful in the treatment of migraine headache. In 1964, Graham (1) described two patients on chronic methysergide therapy who developed retroperitoneal fibrosis. Since then, fibrosis associated with methysergide has also been reported to involve the pleura, lung, endocardium, heart valves, and great vessels (1-3). We describe a patient who developed constrictive pericarditis while on chronic methysergide therapy.A 77-year-old woman was admitted to North Carolina Memorial Hospital with dyspnea and edema. Five years earlier she was evaluated at an affiliated hospital for a right pleural effusion and pleural fibrosis. At that time, skin testing with...References1. GRAHAMSUBYLECOMPTESADOWSKY JHPN: Fibrotic disorders associated with methysergide therapy for headache. TV Engl J Med 274:359-368, 1966 CrossrefMedlineGoogle Scholar2. DUNNSLOAN JH: Pleural effusion and fibrosis secondary to sansert administration. Ann Thorac Surg 15:295-298, 1973 CrossrefMedlineGoogle Scholar3. BANAMACNEALLECOMPTESHAHGRAHAM DPPYJ: Cardiac murmurs and endocardial fibrosis associated with methysergide therapy. Am Heart J 88:640-655, 1974 CrossrefMedlineGoogle Scholar4. MEERANAHMEDPARSONSANDERSON MAFC: Constrictive pericarditis due to methysergide therapy. S Afr Med J 50:1595-1597, 1976 MedlineGoogle Scholar5. MILLMANMELLERMOTROBLANKHOROWITZHERMANTEICHHOLZ AJMHIML: Pericardial tumor or fibrosis mimicking pericardial effusion by echocardiography. Ann Intern Med 86:434-436, 1977 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: School of Medicine University of North Carolina at Chapel Hill Chapel Hill, North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByChronic Constrictive Pericarditis Induced by Long-Term Bromocriptine Therapy: Report of Two CasesConstrictive pericarditisConstrictive Pericarditis and Pleuropulmonary Disease Linked to Ergot Dopamine Agonist Therapy (Cabergoline) for Parkinson's DiseaseConstrictive pericarditis: Its history and current statusAn unusual side-effect of long-term methysergide treatmentDrug-induced changes in the radiographic appearance of the heartIntroduction to MigraineMigraine Abortive MedicationMigraine Preventive MedicationHormones and HeadachesMigraine Headache Sample Case StudiesSimulation of acute myopericarditis by constrictive pericardial disease with endomyocardial fibrosis due to methysergide therapyPerikarditis: Klinik, Hämodynamik und differentialdiagnostische ProblemeConstrictive pericarditis: New aspectsDiseases of the pericardium: Morphologic study of surgical specimens from 35 patientsPericardial EchocardiographyRAVI PRAKASH, M.D.Drugs affecting autonomic functions or the extrapyramidal system 1 February 1978Volume 88, Issue 2Page: 213-214KeywordsAlkaloidsDyspneaEdemaEndocardiumFibrosisHeartLungsMigrainePleural effusionPulmonary fibrosis Issue Published: 1 February 1978 PDF DownloadLoading ...