tbuckley/cabot-search huggingface dataset:
THE SCIENTIFIC BASIS FOR VACCINE THERAPY
Authors: RICHARD M. PEARCE
Journal: JAMA (1913)

As a justification for any method of treatment, especially if the method is novel and all-inclusive in the field of proposed application, it is essential that those who apply the method should be convinced that it is based on adequate experience. This basis may be that established by the statistical method of clinical medicine, or it may be that of definite experimentation leading to logical clinical application.  By the statistical method of clinical medicine is meant the study by many physicians of the efficacy of a certain form of treatment as applied to a great number of persons suffering from the same disease. Though we describe treatment so based as empiric in method, such description does not necessarily minimize the importance of the method of treatment or of study on which it is based. Too many remedial agents, though introduced at first in curious and diverse ways, have stood the
Substance Abuse and Violent Crime in Patients With Schizophrenia
Authors: Glen Smith, Matthew Large, Olav Nielssen
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decreased triglyceride levels with low calorie diet and increased renal excretion of uric acid in hyperuricaemic-hyperlipidaemic patients.
Authors: F J Tinahones, F J Soriguer, E Collantes, G Perez-Lindon, P Sanchez Guijo, J A Lillo
Journal: Annals of the Rheumatic Diseases (1995)

determine the utility of measuring MLC concentrations in myositis.
Dane particle DNA polymerase and HBeAg: Impact on clinical, laboratory, and histologic findings in hepatitis B-associated chronic liver disease
Authors: Ljudevit L. Andres, Vinod K. Sawhney, George H. Scullard, Joseph L. Smith, Thomas C. Merigan, William S. Robinson, Peter B. Gregory
Journal: Hepatology (1981)

Fifty patients with chronic HBs antigenemia and Dane particle-associated DNA polymerase and HBeAg in their serum were contrasted to 46 HBsAg positive patients who had neither serum DNA polymerase or HBeAg. The time from acute onset and the duration of antigenemia were longer in patients who were DNA polymerase and HBeAg negative than in those who had both serum markers. Cirrhosis, hypoalbuminemia, and sequelae of chronic liver disease were more common in DNA polymerase, HBeAg negative patients than in those who were positive. These findings are consistent with the hypothesis that active viral replication is an early, albeit prolonged stage in the development of advanced HBsAg-associated liver disease.
Physician Support for Covering and Caring for the Uninsured
Authors: Robert S. Berry
Journal: Annals of Internal Medicine (2004)

Letters3 August 2004Physician Support for Covering and Caring for the UninsuredRobert S. Berry, MDRobert S. Berry, MDFrom PATMOS EmergiClinic and Health & Care for the Uninsured, Greeneville, TN 37745.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-3-200408030-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Kellermann's editorial on physician support for covering the uninsured (1) was flanked by 2 events that will probably do more to improve health care for the uninsured than the numerous position papers promoting universal health coverage. On 6 November 2003, a front-page Wall Street Journal article publicized the growing movement in insurance-free medical clinics (IFMCs), featuring ours as an example (2). On 8 December 2003, health savings accounts (HSAs) were signed into law. The former will provide Americans choosing the latter with lower health care costs. Overhead at practices such as ours runs about one third ...References1. Kellermann AL. Physician support for covering the uninsured: is the cup half empty or half full? [Editorial]. Ann Intern Med. 2003;139:858-9. [PMID: 14623623] LinkGoogle Scholar2. Rundle RL. Pay-as-you-go M.D.: the doctor is in, but insurance is out. The Wall Street Journal. Accessed at online.wsj.com on 6 November 2003. Google Scholar3. Rogers L. Patients to get treatment funded by NHS in Europe. The Sunday Times. Accessed at sunday-times.co.uk on 11 August 2002. Google Scholar4. Arnold T. Waiting lists are longest ever: report average time from referral to treatment is 16.5 weeks. National Post. Accessed at www.canada.com/national/nationalpost on 12 September 2002. Google Scholar5. Christensen CM, Bohmer R, Kenagy J. Will disruptive innovations cure health care? Harv Bus Rev. 2000;78:102-12, 199. [PMID: 11143147] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From PATMOS EmergiClinic and Health & Care for the Uninsured, Greeneville, TN 37745. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPhysician Support for Covering the Uninsured: Is the Cup Half Empty or Half Full? Arthur L. Kellermann Metrics Cited ByIdentification of Alternative Insurance Model using Fuzzy AHP 3 August 2004Volume 141, Issue 3Page: 244KeywordsDecision makingHealth careHealth care qualityHealth insurancePatientsSurgery ePublished: 3 August 2004 Issue Published: 3 August 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Improved Calf Stretch for Nocturnal Cramp Prevention
Authors: Harry W. Daniell, Jennifer Pentrack
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Conventional histology vs. three-dimensional histology in lentigo maligna melanoma
Authors: M. Moehrle, K. Dietz, C. Garbe, H. Breuninger
Journal: British Journal of Dermatology (2006)

Conventional surgery for lentigo maligna melanoma (LMM) is based on normal histological evaluation. However, such evaluation leaves diagnostic gaps. In contrast, complete three-dimensional (3D) histology of excision margins permits accurate detection of continuously spreading tumour strands like those of LMM. These can be specifically excised in tumour-positive areas with smaller excision margins, and better cosmesis and function. To date there have been no controlled studies of micrographic surgery of LMM.Clinical parameters and surgical strategies influencing the prognosis of patients with LMM were evaluated in a prospective study of melanoma patients in the Department of Dermatology of the University of Tübingen (1980-99).The 292 LMMs comprised 7.4% of 3960 primary stage I and II melanomas treated during this period. One hundred and thirty-six patients in this group (46.6%) underwent surgery on the basis of 3D histology.The geometric mean excision margins were significantly smaller in the 3D histology group (P < 0.0001). Patients with micrographic surgery had fewer recurrences. Multivariate analysis of clinical, histological and surgical variables was carried out, and tumour thickness and 3D histology proved to be independent, significant factors for the prognosis of recurrence-free survival (relative risk, RR 2.08, P < 0.0001 and RR 2.11, P = 0.0037, respectively). There were no melanoma-related deaths in the 3D histology group. All 16 melanoma-related deaths were observed among the 156 patients of the conventional histology group (10.3%).Excision of LMM using 3D histology resulted in a twofold lower probability of recurrence and twofold smaller excision margins. 3D histology is a valuable diagnostic tool and can be used in the management of LMM because of the latter's pattern of continuous tumour spread.
Alexithymia: Subscales and Relationship to Depression
Authors: Mark G. Haviland, Dale G. Shaw, Michael A. Cummings, James P. MacMurray
Journal: Psychotherapy and Psychosomatics (1988)

The purpose of this study was to determine the extent to which Toronto Alexithymia Scale (TAS) scores and derived subscale scores changed in a sample of newly abstinent alcoholic inpatients. Subjects completed the TAS and the Beck Depression Inventory (BDI) on the date of their application for care (Time 1) and at the end of their 3rd week in treatment (Time 2). Patients' mean BDI scores dropped significantly from Time 1 to Time 2; however, the expected concomitant drop in mean TAS scores did not occur. TAS subscales analysis suggests that the subscale associated with the ability to identify one's feelings and to distinguish them from bodily sensations may capture the alexithymia construct better by itself than when combined with the second 2 subscales, daydreaming and external thinking, to create the total TAS score.
HIV Infection in Thailand: The Use of Condoms-Reply
Authors: Kenrad E. Nelson
Journal: JAMA (1994)

<h3>In Reply.</h3> —Dr VanLandingham is critical of the measure of condom use given in our study of HIV infections in young men in northern Thailand. We used self-reported condom use with last CSW instead of usual condom use in order to improve the recall of the subjects. However, we asked participants several questions about their use of condoms, including frequency of usual condom use with CSWs and other sexual partners. Each of these condom-use variables was examined for its association with HIV-1 prevalence in univariate and multivariate analysis. In univariate analysis, we found either no significant association between reported condom use and HIV-1 prevalence or an increased prevalence associated with more frequent reported condom use with CSWs. For example, among men who reported usually using condoms with CSWs, the HIV prevalence was 18.5%, compared with 13.8% in those reporting some condom use but "less than half the time" and 9.4%
Booked admissions as a replacement for waiting lists in the new NHS.
Authors: S Frankel, J Coast, T Baker, C Collins
Journal: BMJ (1991)

Admission arrangements for elective surgery often seem archaic and out of step with the public's experience of services outside the National Health Service.In a consumer oriented NHS it would clearly be preferable to offer most patients a mutually agreeable date for admission.We consider here the place of booked admission systems within the NHS and discuss surgeons' own experiences and preferences about booked admissions for elective surgery.
Unexpected Abrupt Increase in Left Ventricular Assist Device Thrombosis
Authors: Randall C. Starling, Nader Moazami, Scott C. Silvestry, Gregory Ewald, Joseph G. Rogers, Carmelo A. Milano, J. Eduardo Rame, Michael A. Acker, Eugene H. Blackstone, John Ehrlinger, Lucy Thuita, Maria M. Mountis, Edward G. Soltesz, Bruce W. Lytle, Nicholas G. Smedira
Journal: New England Journal of Medicine (2013)

We observed an apparent increase in the rate of device thrombosis among patients who received the HeartMate II left ventricular assist device, as compared with preapproval clinical-trial results and initial experience. We investigated the occurrence of pump thrombosis and elevated lactate dehydrogenase (LDH) levels, LDH levels presaging thrombosis (and associated hemolysis), and outcomes of different management strategies in a multi-institutional study.
Should Hypercholesterolemia in Elderly Persons Be Treated?
Authors: Robert S. Bernstein
Journal: Annals of Internal Medicine (1990)

Letters15 October 1990Should Hypercholesterolemia in Elderly Persons Be Treated?Robert S. Bernstein, MDRobert S. Bernstein, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-8-636 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Before we start a massive treatment program for hypercholesterolemia in elderly persons, as recommended in the review article by Denke and Grundy (1) and endorsed in the editorial by Kafonek and Kwiterovich (2), several notes of caution must be injected. I would emphasize that the recommendation to treat is based on extrapolation of data from younger patients and that there is currently no evidence that lowering cholesterol levels will alter the risk for heart disease in the elderly. Even the current studies have not looked at persons in their 70s and 80s. Yet these people have heard...References1. Denke M and Grundy S. Hypercholesterolemia in elderly persons: resolving the treatment dilemma. Ann Intern Med. 1990;112:780-92. LinkGoogle Scholar2. Kafonek S and Kwiterovich P. Treatment of hypercholesterolemia in the elderly. Ann Intern Med. 1990;112:723-5. LinkGoogle Scholar1. Denke M and Grundy S. Hypercholesterolemia in elderly persons: resolving the treatment dilemma. Ann Intern Med. 1990;112:780-92. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert S. Bernstein, MDAffiliations: 400 West 43rd Street New York, NY 10036 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1990Volume 113, Issue 8Page: 636-637KeywordsCardiovascular therapyCholesterolElderlyExtrapolation ePublished: 1 December 2008 Issue Published: 15 October 1990 PDF downloadLoading ...
Generalized Pustular Psoriasis Induced by Potassium Iodide
Authors: Walter B. Shelley
Journal: JAMA (1967)

Two patients with recurrent generalized pustular psoriasis of von Zumbusch were studied. Systemic manifestations of this disease included hepatitis, fever, leukocytosis, hypoproteinemia, hypocalcemia, and elevations of serum transaminase and alkaline phosphatase levels. Typical attacks were induced by challenge with 500 mg of orally administered potassium iodide. Salicylates also appeared to have an adverse effect. By strict avoidance of iodides and salicylates prolonged complete remissions were achieved in both patients. However, in one patient premenstrual flares occurred and a single oral challenge with 5 mg of progesterone was followed by a minor clinical attack of pustular psoriasis. It is postulated that iodides trigger attacks by stimulating the activity of cellular dihydrofolic reductase, essential in the metabolic pathways involved in the cell division necessary for the clinical expression of the disease. Inhibition of this enzyme by folic acid antagonists is known to produce remissions in the disease. Further study of the folic acid pathway in psoriasis is needed.
Evaluation of Regional and Nonregional Poison Centers
Authors: Dennis F. Thompson, Harold L. Trammel, Nancy J. Robertson, J. Routt Reigart
Journal: New England Journal of Medicine (1983)

The purpose of this study was to determine whether regional poison centers handle a particular poisoning situation better than nonregional centers do. Informed consent was obtained from 15 regional and 15 nonregional poison centers. A case involving salicylate ingestion by a three-year-old child was presented twice (one day call and one night call) to each center. Those answering the phone at the regional centers asked more information-gathering questions than did those at the nonregional centers (P less than 0.01) and were more proficient in their history taking (P less than 0.01). Nonregional centers did not consider the potentially toxic ingestion (220 mg per kilogram of body weight) important enough to treat or were not willing to handle the poisoning in one third of the calls. The nonregional centers recommended manual stimulation to induce emesis in 30 per cent of the calls, whereas none of the regional centers recommended this treatment. Four calls to the nonregional centers resulted in recommendations of inappropriate emetics--e.g., saltwater, raw eggs, or mustard water. The chance of obtaining incorrect recommendations for poisoning treatment from the nonregional centers was determined to be nine times greater than that from the regional centers. Indications of intention to follow up were twice as frequent among regional as among nonregional centers. These data strongly suggest that regional poison centers provide better and more consistent poison information than do nonregional centers.
Folate supplementation and twinning in patients with sickle cell disease
Authors: Samir K. Ballas, Jason K. Baxter, Gaye Riddick
Journal: American Journal of Hematology (2006)

Patients with sickle cell disease routinely take folic acid daily as a supplement to maintain effective erythropoiesis. One of the controversial effects of folic acid is its effect on twin gestation rates. In this report, we present our experience in patients with sickle cell disease and twin pregnancy. Our data show that twin pregnancies seem to be associated with folate supplementation.
A COMPARATIVE STATISTICAL STUDY OF GENERAL PARALYSIS
Authors: Charles Ricksher
Journal: American Journal of Psychiatry (1907)

1. General paralysis seems to be less frequent in the United States than in the continental countries. 2. Males are affected much more frequently than females. 3. The greatest number of cases occur after the age of 30 and before the age of 50 years. 4. Comparatively few cases last longer than four years, the majority dying in the first two years after admission to a hospital. 5. Married men are much more frequently affected than are single men. 6. In the United States, Jews are not more frequently affected than other races. 7. Brain workers are much more often affected than those who have little mental work. 8. Heredity is not an active factor in the causation of the disease, but when joined with other causes it occupies a not unimportant place. 9. Syphilis is the fundamental cause with alcohol and sexual excesses and mental stress as determining causes. 10. The disease is usually well advanced before a diagnosis is made, due to the indefiniteness of the prodromal symptoms. 11. The gait and writing are changed in a large percentage of the cases on admission to the hospital, due to the muscular tremor and weakness, and to the diminished activity of the psychic functions. 12. The pupillary disturbances are the most frequent of the ocular disturbances found, and inequality of the two pupils and diminution in the light reflexes are the most important of these. 13. The tendon reflexes are frequently exaggerated, but vary in the different stages of the disease, and in the third stage are least often exaggerated. 14. The cremasteric reflex is very often irregular on the two sides, and there is no rule for its diminution or exaggeration. 15. In a majority of well-marked cases, the sexual power is diminished, being exaggerated only in the early stages. 16. The memory and attention are practically always affected in well-marked cases. 17. Sensory disturbances are not infrequent and neuritic symptoms are often found in the early stages. 18. The cerebro-spinal fluid in practically every case shows an increase in albumin and cellular constituents, the small lymphocytes predominating. 19. The grandiose type of the disease predominates, only one-fifth of the cases belonging to the depressed form. 20. Convulsive seizures may occur very early in the disease and in about one-half of the cases occur at some period. They may occur regularly for a long time before death appears. 21. Death by exhaustion is most frequent. In this hospital, there were no deaths from an intercurrent affection.
Immunohistochemical analysis of the cell cycle-associated antigens Ki-67 and retinoblastoma protein in parathyroid carcinomas and adenomas
Authors: Ricardo V. Lloyd, J. Aidan Carney, Jorge A. Ferreiro, Long Jin, Geoffrey B. Thompson, Jon A. van Heerden, Clive S. Grant, Peter C. Wollan
Journal: Endocrine Pathology (1995)
Adenovirus-mediated transfer of a gene encoding cholesterol 7 alpha-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol.
Authors: D K Spady, J A Cuthbert, M N Willard, R S Meidell
Journal: Journal of Clinical Investigation (1995)

Clinical interventions that accelerate conversion of cholesterol to bile acids reduce circulating low density lipoprotein (LDL) cholesterol concentrations. The initial and rate-limiting step in the bile acid biosynthetic pathway is catalyzed by hepatic cholesterol 7 alpha-hydroxylase. To examine the effects of transient primary overexpression of this enzyme on sterol metabolism and lipoprotein transport, we constructed a recombinant adenovirus in which a cDNA encoding rat 7 alpha-hydroxylase is expressed from the human cytomegalovirus immediate-early promoter (AdCMV7 alpha). Syrian hamsters administered AdCMV7 alpha intravenously accumulated transgene-specific mRNA in the liver and demonstrated a dose-dependent increase in hepatic microsomal 7 alpha-hydroxylase activity. The increased conversion of cholesterol to bile acids resulted in a compensatory increase in hepatic cholesterol synthesis. In addition, overexpression of 7 alpha-hydroxylase reduced the rate of LDL cholesterol entry into the plasma space and, in animals maintained on a Western-type diet, restored hepatic LDL receptor expression. As a consequence, plasma LDL concentrations fell by approximately 60% in animals maintained on control diet and by approximately 75% in animals consuming a Western-type diet. Plasma high density lipoprotein cholesterol levels were reduced to a lesser degree. These results demonstrate that transient upregulation of bile acid synthesis by direct transfer of a 7 alpha-hydroxylase gene favorably alters circulating lipoprotein profiles and suggest one potential molecular target for genetic strategies aimed at reducing cardiovascular risk.