tbuckley/cabot-search huggingface dataset:
Management of Fibromyalgia
Authors: Frederick Wolfe
Journal: Annals of Internal Medicine (2000)

Letters20 June 2000Management of FibromyalgiaFrederick Wolfe, MDFrederick Wolfe, MDArthritis Research Center Foundation; Wichita, KS 67214 (Wolfe)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Leventhal's review of fibromyalgia treatment (1) fails to indicate that long-term studies have not shown useful benefit from fibromyalgia treatment. Somewhat surprisingly, he omits from his review our multicenter, 7-year study on fibromyalgia outcomes among 538 patients who were seen in the clinics of fibromyalgia experts and who were exposed to many of the treatments labeled as effective in Leventhal's review (2). It appears useful to repeat our study conclusions: “Patients with established fibromyalgia, seen in rheumatology centers in which there was a special interest in the disease, and who were not followed up for as ...References1. Leventhal LJ. Management of fibromyalgia. Ann Intern Med. 1999;131:850-8. LinkGoogle Scholar2. Wolfe F, Anderson J, Harkness D, Bennett RM, Caro XJ, Goldenberg DL, et al . Health status and disease severity in fibromyalgia: results of a six-center longitudinal study. Arthritis Rheum. 1997;40:1571-9. CrossrefMedlineGoogle Scholar3. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al . The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33:160-72. CrossrefMedlineGoogle Scholar4. Wolfe F. The fibromyalgia syndrome: a consensus report on fibromyalgia and disability. J Rheumatol. 1996;23:534-9. MedlineGoogle Scholar5. Wolfe F. The fibromyalgia problem. J Rheumatol. 1997;24:1247-9. MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Arthritis Research Center Foundation; Wichita, KS 67214 (Wolfe) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoManagement of Fibromyalgia Lawrence J. Leventhal Management of Fibromyalgia Arthur Huppert Management of Fibromyalgia Norman Muilenburg Management of Fibromyalgia Hideto Akama Management of Fibromyalgia Lawrence J. Cohn Management of Fibromyalgia Lawrence J. Leventhal Metrics 20 June 2000Volume 132, Issue 12Page: 1004KeywordsDisabilitiesFatigueFibromyalgiaPainRheumatic painRheumatologySleep Issue Published: 20 June 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
A hand and a name.
Authors: A Friedberg
Journal: BMJ (1984)

As usual, I went to play the guitar this evening for the patients at University College Hospital. Since I came to Britain as a foreign transfer student from the United States I have changed many of my ways, but this music routine has become a habit. When the sun sets on Friday evening the minstrel who rests quietly in me during the week wakes up. Lately, I have been playing the guitar for patients in ward 4/3, a ward primarily for chronically ill patients. There is a sincerity about people who are close to death that I enjoy because I have a sense that my songs resonate more deeply in them. Tonight I was performing for two men and a woman in the back left hand corner of the alcove off to the left when you walk into the ward, and the patient in the bed behind me began to die. I was certain of this as a nosy old woman in the bed next to her announced that she was dying and because a young nurse came and drew the curtains around her and stayed with her. The staff nurse asked me please to leave, but on my request permitted me to remain quietly in my place. While Mrs A was dying things were much the same in the ward. Patients continued to be patients, and nurses busily attended to their needs. Except for me and the nosy old woman, no one displayed any interest. I listened with obvious attention, concentration fixed on what was happening behind the curtain. I recalled how Monet had sat by the side of his dying wife, held her hand and watched her skin change from pink to pale to an ash blue, watched the red life flow from her veins, and whispered her name. Mrs A died quietly, and it was not until the young nurse stepped out from behind the curtain that I knew for sure of her death. The body was left untouched for an hour, then removed in a deep box. Within ten minutes a fresh and empty bed was in place, and the nosy old woman talked nosily over it about the happening to a kind listener. Eventually, I left the hospital feeling an earnest sorrow about the death of a good person whom I knew from my previous visits to the ward, but I was also impressed by certain aspects of her death.
Coal mining and COPD
Authors: W K C MORGAN;, D COGGON, A N. TAYLOR
Journal: Thorax (1999)

Inhaled corticosteroids in COPDThe importance of presenting absolute cell numbers when counting cells in biological samples is illustrated by the potentially misleading interpretation of data in the paper by Marco Confalonieri and colleagues. 1 The authors concluded that, in addition to reduced sputum neutrophilia, the number of sputum macrophages increased significantly following treatment with inhaled beclomethasone dipropionate in patients with COPD.However, the observed increase in the proportion of sputum macrophages from 19.6% before treatment to 35.8% following treatment is entirely attributable to the reduced number of sputum neutrophils.From the data presented in the paper, the absolute numbers of diVerent cells in the sputum can be calculated (table 1), revealing that the absolute sputum macrophage count was essentially unchanged following treatment.It is important that the absolute numbers of cells, and not simply their proportions, are presented when measuring diVerential cell counts in sputum or any other biological sample.
Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice
Authors: Xiaodong Wang, Yongke Lu, Arthur I. Cederbaum
Journal: Hepatology (2005)

Cytochrome P450 2E1 (CYP2E1) may be a central pathway in generating oxidative stress, reactive oxygen species, and causing hepatotoxic injury by alcohol and various hepatotoxins. This study evaluated the ability of CYP2E1 to potentiate or synergize the hepatotoxicity of Fas in vivo. C57BL/6 mice were injected intraperitoneally with pyrazole (Pyr) to induce CYP2E1. Then, 16-hour fasted mice were administered agonistic Jo2 anti-Fas antibody ip. Other mice were treated with Pyr or Jo2 alone. Levels of serum aminotransferase were 8.3- and 6.3-fold higher in the Pyr/Jo2 group compared with Jo2 alone, respectively. Histological evaluation of liver showed more extensive acidophilic necrosis and severe pathological changes in the Pyr/Jo2-treated mice. DNA fragmentation and caspase-8 and -3 activities were more elevated in the Pyr/Jo2 group compared with Jo2 alone. CYP2E1 activity and protein levels were higher in the Pyr/Jo2 group than in Jo2 alone. Levels of inducible nitric oxide synthase, 3-nitrotyrosine protein adducts, malondialdehyde, and protein carbonyls were also higher in the Pyr/Jo2 group compared with Jo2 alone. Glutathione and activities of catalase and Cu-Zn superoxide dismutase were decreased in the Pyr/Jo2 group. Administration of chlormethiazole, an inhibitor of CYP2E1, to the Pyr/Jo2-treated mice caused a significant decrease of alanine aminotransferase and liver pathological changes in association with a decrease in CYP2E1 protein and activity. In conclusion, enhanced hepatotoxicity of Fas was found in mice with elevated levels of CYP2E1. We speculate that overexpression of CYP2E1 might synergize and increase the susceptibility to Fas induced-liver injury. (HEPATOLOGY 2005;42:400–410.)
Latent cytomegalovirus infection in blood donors
Authors: P. Diosi, E. Moldovan, N. Tomescu
Journal: BMJ (1969)

Twenty-one out of 32 apparently healthy blood donors aged 21 to 65 years yielded positive complement fixation tests with a cytomegalovirus antigen, at titres ranging from 1:8 to 1:64. Virus was present in leucocyte cultures of fresh peripheral blood of two seropositive subjects from a total of 35 donors examined. Plasma and 48-hour stored blood specimens failed to disclose virus in culture. Viruria could not be demonstrated, and there was no evidence of recent illness in the study group. These findings suggest that subclinical viraemia is not uncommon in blood donors.
LEISHMANIA DONOVANI AND LEISHMANIA TROPICA
Authors: R. Row
Journal: BMJ (1912)

In 1904, a year after the discovery of the Leishman- Donovan body by Leishmnan' and Donovan,2 Rogers3 grew this parasite for the first time in culture, and demonstrated its various developmental forms up to its flagellate stage.The results obtained by Rogers in Calcutta were confirmned subsequently by Cliatterjee,4
Oral Medicine: Diagnosis and Treatment
Authors: Moses S. Strock
Journal: JAMA (1962)

This excellent text book has served as a standard for many others and well merits republication in a fourth edition. The photographs which illustrate the many diseases described are excellent. The colored atlas is very good, and all in all, this is a volume which is valuable to the student and practitioner alike. Since it is likely that this publication will come to many more editions, these small suggestions are made: Hypoparathyroidism is dismissed with a few paragraphs. It is, however, important that the dentist recognize the "blunting" of the roots which is still unexplained, the significance of enamel changes as an indication of recurrent attacks while the crown was being formed, and the abnormalities of eruption. The statement that "sections of jaw bones can be removed by an ordinary scalpel" is not correct in this reviewer's experience with hyperparathyroidism; nor has he ever seen teeth become loose in the
Assessment of Pancreatic Parenchymal Invasion by Bile Duct Cancer Using Intraductal Ultrasonography
Authors: K. Tamada, N. Ueno, M. Ichiyama, T. Tomiyama, T. Nishizono, S. Wada, A. Oohashi, S. Tano, T. Aizawa, K. Ido, K. Kimura
Journal: Endoscopy (1996)

Background and Study Aims: This study was performed to clarify the diagnostic accuracy of intraductal ultrasonography (IDUS) in assessing pancreatic parenchymal invasion by bile duct cancer.
Suture Material and Suture Line Ulcer Following Gastric Surgery
Authors: W. Roesch
Journal: Endoscopy (1970)

The importance of gastroscopy in patients with upper abdominal complaints following gastric resection is stressed, especially when X-ray examinations are negative. Non-absorbable suture material and its sequelae like granuloma or ulcer form a distinct entity in the postoperative stomach which may be responsible for ulcer-type pain or minor bleeding. This completely avoidable lesion should be familiar to all clinicians.
Pneumonia as an Early Sign Of Bronchogenic Cancer
Authors: Daniel Roth
Journal: JAMA (1967)

To the Editor:—  It seems appropriate at the start of this winter season to remind physicians that the symptoms and signs of bronchogenic cancer are indistinguishable from those of pneumonia. There is a recurring pattern, in case histories of cancer, of excessively long treatment for slowly resolving pneumonitis before the realization of the true nature of the patient's illness comes about. It should be kept in mind that the most important respiratory disease of American males today is bronchogenic cancer, not pneumonia.  Practitioners should consider malignancy at the very outset of pneumonitis in males over 30, especially those who are heavy smokers, and initiate diagnostic tests early. The simplest and possibly the most accurate procedure is to obtain a series of sputum samples for cytological analysis at the start of illness in every instance of pneumonitis. (Bacteriological examination would also be worthwhile.) Granted that surgical cure is uncommon, it is
INTERRELATIONS BETWEEN ARTERIAL PRESSURE, FLUID-VOLUMES, AND PLASMA-RENIN CONCENTRATION IN THE COURSE OF ACUTE GLOMERULONEPHRITIS
Authors: W.H. Birkenhäger, M.A.D.H. Schalekamp, M.P.A. Schalekamp-Kuyken, G. Kolsters, X.H. Krauss
Journal: The Lancet (1970)
Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD
Authors: Ahmad Khoder, Anushruti Sarvaria, Abdullah Alsuliman, Claude Chew, Takuya Sekine, Nichola Cooper, Stephan Mielke, Hugues de Lavallade, Muharrem Muftuoglu, Irina Fernandez Curbelo, Enli Liu, Paolo A. Muraro, Amin Alousi, Kate Stringaris, Simrit Parmar, Nina Shah, Hila Shaim, Eric Yvon, Jeffrey Molldrem, Rayne Rouce, Richard Champlin, Ian McNiece, Claudia Mauri, Elizabeth J. Shpall, Katayoun Rezvani
Journal: Blood (2014)
REMOVAL OF IRON FROM INTERIOR OF THE EYE BY ELECTRO-MAGNET
Authors: A. S. Percival
Journal: BMJ (1905)

CASE I.The patient came under my care during the absence from home of her own medical adviser.There was considerable oedema and albuminuria, and also valvular disease of the heart.Her doctor had given a very poor prognosis of the result of her canfinement.She sent for me one
Shock in Myocardial Infarction
Authors: Arthur J. Moss
Journal: JAMA (1974)

The past few years have seen an increase in shock complicating myocardial infarctions. This book highlights some of the advances resulting from studies in this field carried out at the Cook County Hospital and the University of Illinois College of Medicine, between 1962 and 1971. The three coeditors recruited 14 prior and present co-investigators to summarize their contributions in 12 chapters. The individual chapters contain various mixtures of literature review and original data with some results not previously published. The references at the end of each chapter are thorough and up to date into 1973. The introductory chapter on coronary arteries and myocardium in shock is outstanding and is essential reading for anyone trying to understand whether coronary thrombosis is a mechanism or a marker of the shock syndrome. The chapter on myocardial metabolism by Mueller and Ayres contains a wealth of valuable clinical information that has been obtained by
Some Operative Factors of Seaside Climate
Authors: O. H. Kestner
Journal: BMJ (1940)

MEDRCTALSoIN 169 partictularly when they are not Llcerative.All cases of suspected pulmonary tuberculosis should have the larynx examined as part of the diagnostic procedure, and patients tinder treatment for pulmonary tuberculosis should have regular periodic laryngeal examinations.We have to thank Dr. Allen Daley, Medical Officer of Health, London County Council, for permission to quote work done at London Countv Council hospitals;
Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs.
Authors: P R Krause, L R Stanberry, N Bourne, B Connelly, J F Kurawadwala, A Patel, S E Straus
Journal: The Journal of Experimental Medicine (1995)

The latency-associated transcript (LAT) is the only herpes simplex virus (HSV) gene product detectable in latently infected humans and animals. In this report, we show that a 624-bp deletion in the promoter of the HSV-2 LAT had no discernable effect on viral growth in tissue culture or in acute genital infection of guinea pigs, but impaired LAT accumulation and led to a marked decrease in spontaneous genital recurrences when compared with the behavior of wild-type and rescuant strains. Differences in the ability of the mutant to replicate, or in how readily it established or maintained latency did not account for this finding. Thus, HSV LAT expression facilitates the spontaneous reactivation of latent virus.
Talking about Treatment
Authors: John F. Steiner
Journal: Annals of Internal Medicine (2000)

Letters4 January 2000Talking about TreatmentJohn F. Steiner, MD, MPHJohn F. Steiner, MD, MPHUniversity of Colorado Health Sciences Center; Denver, CO 80262 (Steiner)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-1-200001040-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The commentaries on our paper suggest several alternative approaches to quantitative risk communication. Drs. Saitz and Kessler all propose the use of the absolute risk reduction rather than its reciprocal, the number needed to treat, while Dr. Peirce proposes a comparison among relative odds for treated and untreated patients. Because we already know that the relative risk reduction and the number needed to treat “frame” decisions in ways that lead to different treatment choices (1, 2), we must be cautious in advocating other quantitative measures without evaluating their potential impact. A comparison between the absolute risk reduction and ...References1. Naylor CD, Chen E, Strauss B. Measured enthusiasm: does the method of reporting trial results alter perceptions of therapeutic effectiveness? Ann Intern Med. 1992;117:916-21. LinkGoogle Scholar2. Hux JE, Naylor CD. Communicating the benefits of chronic preventive therapy: does the format of efficacy data determine patients' acceptance of treatment? Med Decis Making. 1995;15:152-7. CrossrefMedlineGoogle Scholar3. Davidoff F. Evangelists and snails redux: the case of cholesterol screening [Editorial]. Ann Intern Med. 1996;124:513-4. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Colorado Health Sciences Center; Denver, CO 80262 (Steiner) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 January 2000Volume 132, Issue 1Page: 94KeywordsAbsolute risk reductionRelative riskTreatment guidelines Issue Published: 4 January 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
INCREMENTAL PROGNOSTIC VALUE OF LEFT VENTRICULAR FUNCTION ANALYSIS OVER CORONARY ANGIOGRAPHY WITH MULTI-DETECTOR COMPUTED TOMOGRAPHY
Authors: Fleur Rianne de Graaf, Jacob van Werkhoven, Joanne Schuijf, Joëlla van Velzen, Lucia Kroft, Albert de Roos, Martin Schalij, J. Wouter Jukema, Ernst van der Wall, Jeroen Bax
Journal: Journal of the American College of Cardiology (2010)
Retained Surgical Sponge Following Laminectomy
Authors: Robert R. M. Gifford
Journal: JAMA (1973)

<h3>To the Editor.—</h3> We wish to report a case of retained surgical sponge following lumbar laminectomy. The patient underwent bilateral, partial hemilaminectomy with excision of an L5-S1 herniated nucleus pulposus that had been demonstrated myelographically on the right. Exploration of the left S-1 root through the left partial hemilaminectomy was hampered by significant bleeding that was controlled with neurosurgical cottonoids (small surgical sponges on strings). Before closing the incision, the wound was carefully inspected for hemostasis and sponges. Postoperatively, the patient complained of episodic hypalgesia over the lateral aspect of both thighs. During the next month, persistence of the hypalgesia was accompanied by back and bilateral radicular pain. Repeat myelogram demonstrated a posterior extradural defect at the level of the L4-5 disc. Contained within this mass was a radiopaque sponge marker (Figure). At the second operation, exploration of the L4-5 level, which was one level higher than at the initial
Endoscopic Mucosal Resection for Advanced Sessile Adenoma and Early-Stage Colorectal Carcinoma
Authors: E. Bories, C. Pesenti, G. Monges, B. Lelong, V. Moutardier, J. Delpero, M. Giovannini
Journal: Endoscopy (2006)

The aim of this study was to evaluate the efficacy and outcomes of treatment by endoscopic mucosal resection (EMR) of patients with high-grade dysplasia (HGD) or carcinoma.Between January 1995 and January 2002, 50 patients (35 men, 15 women) were treated by EMR for 52 sessile polyps. The median size of the polyps was 27.5 mm (range 10-60). The "lift and cut" EMR technique was used. If the lesion was poorly differentiated or infiltrated the muscularis mucosae to more than 1000 microm, the patient was referred for colectomy. In the other cases, follow-up was proposed.Complications occurred in 9.6 % of cases and were always treated conservatively. The rate of endoscopically complete resection was judged to be 98.1 %. Argon plasma coagulation was applied to the margins of the lesion in 21.6 % of cases. Histological examination showed 38 HGDs and 14 carcinomas. Seven patients had a lesion reaching the deep or lateral margin; four were referred for surgery; two patients for whom surgery would have been high risk were followed up, and both developed local recurrence; and one patient was followed up, without recurrence, because infiltration was less than 1000 microm. A total of 43 patients were followed up after complete excision. Two patients died during follow-up; neither death could be reliably attributed to colorectal carcinoma. Seven patients were lost during the follow-up. For 34 patients, information from a mean follow-up of 17.3 months (6 - 57) was available and recurrence was observed in five cases (15 %).EMR appears to be a safe and efficient treatment of HGD and early colorectal cancer. However, correct analysis of submucosal infiltration is essential to assess the completeness of the resection.
Role of cerebrospinal fluid pleocytosis and Haemophilus influenzae type b capsule on blood brain barrier permeability during experimental meningitis in the rat.
Authors: A J Lesse, E R Moxon, A Zwahlen, W M Scheld
Journal: Journal of Clinical Investigation (1988)

The influence of leukocytes and Haemophilus influenzae type b (Hib) capsule on blood brain barrier permeability (BBBP) to circulating 125I-albumin in normal and leukopenic rats was assessed after intracisternal inoculation of encapsulated (Rd-/b+/02) or unencapsulated (Rd-/b-/02) isogenic strains of Hib. Both normal and leukopenic animals had increased BBBP 18 h after inoculation, with normal rats demonstrating significantly increased BBBP after challenge with the encapsulated strain. Despite cerebrospinal fluid (CSF) pleocytosis in normal rats, CSF bacterial concentrations were not lower. Normal rats cleared unencapsulated Rd-/b-/02 more effectively than leukopenic rats, with BBBP correlating with CSF bacterial density and not leukocyte concentrations. Challenge with heat-killed Rd-/b+/02 resulted in increased BBBP in both normal and leukopenic rats, with greater BBBP at higher bacterial concentrations. The data suggest: (a) significant increases in BBBP occur in the near absence of CSF leukocytes; (b) CSF leukocytes can augment changes in BBBP; (c) type b capsule inhibits host clearance mechanisms within the CSF; and (d) BBBP appears to correlate with bacterial concentrations within the CSF.
The true lorcainide story
Authors: I. Chalmers
Journal: BMJ (2015)

In 1993, Cowley and colleagues reported a controlled trial of the anti-arrhythmic drug lorcainide in heart attack.1 Nine men allocated to the drug had died versus only one man allocated to placebo.

This trial had been completed in 1980. It was eventually reported when the authors saw that it could have provided warning of what, by then, had become clear—that anti-arrhythmic drugs were more likely to be lethal than helpful.

I often use this example to emphasise the importance …
Mutations and long-term outcome of 217 young patients with essential thrombocythemia or early primary myelofibrosis
Authors: F Palandri, R Latagliata, N Polverelli, A Tieghi, M Crugnola, B Martino, M Perricone, M Breccia, E Ottaviani, N Testoni, F Merli, F Aversa, G Alimena, M Cavo, G Martinelli, L Catani, M Baccarani, N Vianelli
Journal: Leukemia (2015)
Tests for lactose malabsorption in adults.
Authors: G Metz, L M Blendis, D J Jenkins
Journal: BMJ (1975)

tion by binding to ristocetin and not by an effect on the platelets or the ristocetin cofactor.There is no evidence that our ob- servation reflects an influence of Haemaccel on the haemostatic mechanism in vivo.All evidence suggests that this inhibition is solely an in-vitro phenomenon.-Weare, etc.,