Influenza Prevention and Treatment: Current Practices and New Horizons
Authors: Robert B. Belshe
Journal: Annals of Internal Medicine (1999)

Editorials19 October 1999Influenza Prevention and Treatment: Current Practices and New HorizonsRobert B. Belshe, MDRobert B. Belshe, MDSaint Louis University School of Medicine; St. Louis, MO 63100 (Belshe)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-8-199910190-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Significant new tools to prevent and treat influenza will become available to clinicians in 1999/2000, and additional advances in vaccine are on the horizon. Advances include new antiviral compounds to treat influenza and new vaccines to prevent the disease. The development of these tools is a direct result of advances in fundamental influenza virology research.We now understand that both influenza A and influenza B viruses have eight genetic segments that encode 10 proteins. Researchers have also elucidated the functions of these proteins. Immunity to influenza in humans is primarily mediated by secretory IgA and serum IgG antibodies directed against ...References1. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep. 1999; 48:1-28. Google Scholar2. Belshe RB, Mendelman PM, Treanor J, King J, Gruber WC, Piedra A, et al . The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children. N Engl J Med. 1998;338:1405-12. CrossrefMedlineGoogle Scholar3. Nichol KL, Mendelman PM, Mallon KP, Jackson LA, Gorse GJ, Belshe RB, et al . Effectiveness of live, attenuated intranasal influenza virus vaccine in healthy, working adults: a randomized, controlled trial. JAMA. 1999;282:137-44. CrossrefMedlineGoogle Scholar4. Powers DC, Smith GE, Anderson EL, Kennedy DJ, Hackett CS, Wilkinson BE, et al . Influenza A virus vaccines containing purified recombinant H3 hemagglutinin are well tolerated and induce protective immune responses in healthy adults. J Infect Dis. 1995;171:1595-9. CrossrefMedlineGoogle Scholar5. Monto AS, Fleming DM, Henry D, de Groot R, Makela M, Klein T, et al . Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza A and B virus infections. J Infect Dis. 1999;180:254-61. CrossrefMedlineGoogle Scholar6. Monto AS, Robinson DP, Herlocher ML, Hinson JM, Elliott MJ, Crisp A. Zanamivir in the prevention of influenza among healthy adults: a randomized, controlled trial. JAMA. 1999;282:31-5. CrossrefMedlineGoogle Scholar7. Hayden FG. Influenza neuraminidase inhibitors [Abstract]. 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, California, 24-27 September 1998. Washington, DC: American Society for Microbiology. Google Scholar Author, Article, and Disclosure InformationAffiliations: Saint Louis University School of Medicine; St. Louis, MO 63100 (Belshe)Corresponding Author: Robert B. Belshe, MD, Department of Internal Medicine, Division of Infectious Diseases, Saint Louis University School of Medicine, 3635 Vista Avenue (FDT-8N), St. Louis, MO 63110; e-mail: [email protected] For reprint orders in quantities exceeding 100, please contact the Reprints Coordinator; phone, 215-351-2657; e-mail, [email protected]acponline.org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEpithelial Sodium Channels (ENaC)Regulation of Lung Epithelial Sodium Channels by Cytokines and ChemokinesDiagnóstico microbiológico de las infecciones virales respiratoriasRespiratory Viral VaccinesEffects of influenza vaccination on mortality among frail, community-living elderly patients: An observational studyInfluenza: Past, Present, and FutureInfluenza Vaccination Coverage Level at a Cystic Fibrosis CenterUpdate on influenza and other viral pneumoniasRecommendations for the Outpatient Surveillance of Renal Transplant RecipientsNew millennium: new antimicrobial agents for respiratory infections; but an old plea 19 October 1999Volume 131, Issue 8Page: 621-623KeywordsAdverse reactionsAntibodiesAntigensAttenuated vaccinesCellsChildrenDrugsElderlyProteinsVaccines Issue Published: 19 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...