A Re-evaluation of Needle Biopsy in the Diagnosis of Metastatic Cancer of the Liver
Authors: HAROLD O. CONN
Journal: Annals of Internal Medicine (1963)

Article1 July 1963A Re-evaluation of Needle Biopsy in the Diagnosis of Metastatic Cancer of the LiverHAROLD O. CONN, M.D., RAYMOND YESNER, M.D.HAROLD O. CONN, M.D.Search for more papers by this author, RAYMOND YESNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-53 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPercutaneous liver biopsy has been demonstrated to be a valuable tool in the diagnosis of metastatic cancer of the liver (1-7). The frequency with which a single liver biopsy demonstrates metastatic cancer in patients proved to have hepatic metastases has been reported to range from 66 (3) to 91 per cent (2) and averages 71 per cent (Table 1). These studies, in which most of the patients have shown obvious signs of metastatic disease of the liver, may have exaggerated its true value. It has been widely stated that the presence of hepatic metastases can be detected by a single...References1. BOWDENKRAVITZ LS: Needle biopsy of the liver. A diagnostic aid in the treatment of cancer. Cancer 6: 1010, 1953. CrossrefMedlineGoogle Scholar2. KLECKNER MS: Needle biopsy of the liver: an appraisal of its diagnostic indications and limitations. Ann. Intern. Med. 40: 1177, 1954. LinkGoogle Scholar3. WARDSCHIFFYOUNGGALL JLPEA: Needle biopsy of the liver. IX. Further experiences with malignant neoplasm. Gastroenterology 27: 300, 1954. CrossrefMedlineGoogle Scholar4. CERNOCK WF: Needle liver biopsy for the diagnosis of neoplasm. Amer. J. Dig. Dis. 22: 71, 1955. CrossrefMedlineGoogle Scholar5. PARETS AD: Detection of intrahepatic metastases by blind needle liver biopsy. Amer. J. Med. Sci. 237: 335, 1959. CrossrefMedlineGoogle Scholar6. NELSONSALVADOR RSDS: Percutaneous needle liver biopsy in malignant neoplasm with special reference to myeloid metaplasia. Ann. Intern. Med. 53: 179, 1960. LinkGoogle Scholar7. FENSTERKLATSKIN LFG: Manifestations of the liver. A study of eighty-one patients. Amer. J. Med. 31: 238, 1961. CrossrefMedlineGoogle Scholar8. YESNERCONN RHO: Liver function tests and needle biopsy in the diagnosis of metastatic cancer of the liver. Ann. Intern. Med. 59: 62, 1963. LinkGoogle Scholar9. FISHERFALOON CJWW: Needle biopsy of the liver. Comparison of initial clinical and histological diagnoses, with a note on post-biopsy mortality in patients with metastatic neoplasm. Amer. J. Med. 25: 368, 1958. CrossrefMedlineGoogle Scholar10. ZAMCHECKKLAUSENSTOCK NO: Liver biopsy. II. The risk of needle biopsy. New Eng. J. Med. 249: 1062, 1953. CrossrefMedlineGoogle Scholar11. BATTAGLIAMCCORMACKBROWN PSLJCH: Needle biopsy of liver in malignant hepatic disease. Amer. J. Gastroent. 34: 397, 1960. MedlineGoogle Scholar12. CONN HO: Unpublished observations. Google Scholar13. WATSON AJ: Diffuse intra-sinusoidal metastatic carcinoma of the liver. J. Path. Bact. 69: 207, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: West Haven, ConnecticutFrom the Medical and Laboratory Services of the West Haven Veterans Administration Hospital, and the Department of Internal Medicine and Pathology, Yale University School of Medicine.This work was supported in part by grant C-2727, United States Public Health Service, and in part during Dr. Conn's tenure of a Veterans Administration Clinical Investigatorship.Requests for reprints should be addressed to Harold O. Conn, M.D., Veterans Administration Hospital, West Spring Street, West Haven 16, Connecticut. 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CONN, M.D. 1 July 1963Volume 59, Issue 1_Part_1Page: 53-61KeywordsBiopsyHospital medicineLiverLiver diseasesMedical servicesPathology and laboratory medicineResearch laboratories Issue Published: 1 July 1963 PDF downloadLoading ...