Familial Multifocal Fibrosclerosis
Authors: DAVID E. COMINGS
Journal: Annals of Internal Medicine (1967)

Article1 May 1967Familial Multifocal FibrosclerosisFindings Suggesting that Retroperitoneal Fibrosis, Mediastinal Fibrosis, Sclerosing Cholangitis, Riedel's Thyroiditis, and Pseudotumor of the Orbit May Be Different Manifestations of a Single DiseaseDAVID E. COMINGS, M.D., K. B. SKUBI, M.D., F.A.C.P., J. VAN EYES, PH.D., M.D., ARNO G. MOTULSKY, M.D., F.A.C.P.DAVID E. COMINGS, M.D.Search for more papers by this author, K. B. SKUBI, M.D., F.A.C.P.Search for more papers by this author, J. VAN EYES, PH.D., M.D.Search for more papers by this author, ARNO G. MOTULSKY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-884 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSclerosing Overgrowths of fibrous tissue have long been known to affect a number of widely separate organ systems. The terms retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, Riedel's sclerosing thyroiditis, and pseudotumor of the orbit reflect the multiple areas involved. Despite the tendency to treat these entities as independent diseases, an increasing number of patients has been reported with fibrotic involvement of more than one of the above areas. With the exception of the recent evidence that methysergide (Sansert®) may produce retroperitoneal fibrosis, the cause of these diverse disorders has remained unknown. The present report concerns two brothers, offspring of a...References1. ORMOND JK: Bilateral ureteral obstruction due to envelopment and compression by an inflammatory retroperitoneal process. J. Urol. 59: 1072, 1948. CrossrefMedlineGoogle Scholar2. HUTCHATKINSONLOQUVAM JARCGS: Perirenal (Gerota's) fascitis. J. Urol. 81: 76, 1959. CrossrefMedlineGoogle Scholar3. 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An anatomic and radiologic review with a report of four new cases and an explanation of pathogenesis. Radiology 75: 380, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, WashingtonFrom the Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Wash.This study was supported in part by grant H 3091, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to David E. Comings, M.D., Department of Medical Genetics, City of Hope Medical Center, Duarte, Calif. 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Associated with Systemic Idiopathic FibrosisLymphoplasmacytic sclerosing pancreatitis with cholangitis: A variant of primary sclerosing cholangitis extensively involving pancreasPseudotumour of the maxillary antrumSurgical Implications of Sclerosing MediastinitisInvasive Fibrous (Riedel's) ThyroiditisAspects scanographiques des fibroses médiastinalesSclerosing Orbital Pseudotumor: A Unique Clinicopathologic EntityIdiopathic fibrosis of the upper aero-digestive tract.Case 6-1989Primary Sclerosing Cholangitis: Clinical AspectsOrbital InflammationsPancreatic pseudotumors associated with multifocal idiopathic fibrosclerosisPathology of Mediastinal TumorsA comparison of cytoplasmic immunoglobulins in retroperitoneal fibrosis and abdominal aortic aneurysmsPrimary sclerosing cholangitis associated with hyperimmunoglobulin M immunodeficiency (dysgammaglobulinemia)Scleroderma and scleroderma-like disordersIdiopathic subcutaneous and laryngeal fibrosisMULTIFOCAL FIBROSCLEROSIS: CUTANEOUS ASSOCIATIONS.Mediastinal and retroperitoneal fibrosis with fibrotic pulmonary nodules: a case reportMultifocal idiopathic fibrosis presenting as facial pain and trismusRiedel's thyroiditis with multiple organ fibrosis.Polyclonal Orbital and Systemic InfiltratesConstrictive Pericarditis Associated With Combined Idiopathic Retroperitoneal and Mediastinal FibrosisIdiopathic Retroperitoneal Fibrosis in TwinsClassificazione Delle Fibrosi Retroperitoneali E Fisiopatologia Della Malattia Di Ormond ()Thyroid Hormones and the LiverCoexisting retroperitoneal and mediastinal fibrosis.Multifocal fibrosclerosis and renal amyloidosis.Multifocal fibrosclerosis associated with suprasellar and macular lesions.Familial mediastinal fibrosis associated with seronegative spondylarthropathyDiffuse lesions of the tracheaAspiration Biopsy Cytology in Diseases of the ThyroidORBITAL PSEUDOTUMOUR AND LACRIMAL INVOLVEMENT DEVELOPING IN A PATIENT WITH RIEDEL'S STRUMA RECEIVING STEROIDSRetroperitoneal fibrosis and scleroderma.Primär sklerosierende Cholangitis und Choledochuskarzinom (Fallbericht)Multifocal Idiopathic FibrosclerosisFasciitis and FibrosisIdiopathic Retroperitoneal Fibrosis: A Systemicconnective Tissue Disease?Zur Pathologie der XanthofibrogranulomatoseOcclusive phlebitis, a diagnostic feature in Riedel's thyroiditisSclerosing mediastinitis with occlusion of pulmonary veinsCase 33-1976Case 13-1976Mediastinitis cronica fibrosa: Aportacion de dos casosSclerosing cholangitis and other intra-abdominal fibrosesIdiopathic Retroperitoneal Fibrosis (Ormond's Disease) with Unusual Extension Involving the BrainPrimary Sclerosing Cholangitis: A Disease RevisitedPathology of 'pseudotumours' of the orbit: a review.Systemic idiopathic fibrosisAortic disease in idiopathic retroperitoneal and mediastinal fibrosisDie retroperitoneale Fibrose (Ormond’sche Krankheit)Invasive Fibrous Thyroiditis (Riedel)Idiopathic Retroperitoneal Fibrosis and Sclerosing Cholangitis Associated with a Reticulum Cell SarcomaTHE REPONSE OF IDIOPATHIC RETPROPERITONEAL FIBROSIS TO CORTICOSTEROIDSPrimary sclerosing cholangitisMultifocal FibrosclerosisThe pathology of idiopathic retroperitoneal fibrosisPseudotumor of the Orbit and Limited Wegener's GranulomatosisSTANLEY M. CASSAN, M.D., MATTHEW B. DIVERTIE, M.D., F.A.C.P., ROBERT W. HOLLENHORST, M.D., EDGAR G. HARRISON JR., M.D.Abdominal fibrodysplasia and polyposis coliMultifocal Fibrosclerosis Manifested by Vena Caval Obstructions and Associated with VasculitisROBERT W. CARTON, M.D., F.A.C.P., RUTH WONG, M.D.Case 47-1968Idiopathic Pelvic Fibrosis Report of a Case with Unusual Histologic and Radiographic FeaturesHOKE SHIRLEY JR., M.D., A. K. GUP, M.D., JOSEPH SPANO, M.D. 1 May 1967Volume 66, Issue 5Page: 884-892KeywordsDyspneaFibrosisMedical geneticsPrimary sclerosing cholangitisSclerodermaSteroid therapyThyroid Issue Published: 1 May 1967 PDF DownloadLoading ...