tbuckley/cabot-search huggingface dataset:
ENGLISH WEIGHTS AND MEASURES
Authors: J. T. Hornback
Journal: JAMA (1926)

To the Editor:  —Under Current Comment,The Journal, February 6, page 422, the editorial writer of a Brazilian journal is quoted as saying: When one tries to reduce English dosage to our own, this involves a series of steps, if not difficult, at least time consuming and  To the average country doctor, the metric system is meaningless, and for him to fathom it would be bothersome. Until our nation adopts the metric system, and all weights and measurements are required to be made by it and all scales changed to that requirement, let us at least use the double system in our medical writings.
Red-Cell 2,3-Diphosphoglycerate and Creatine Levels in Patients with Red-Cell Mass Deficits or with Cardiopulmonary Insufficiency
Authors: C. R. Valeri, N. L. Fortier, Melody J. French
Journal: New England Journal of Medicine (1969)

Since the organic phosphate compounds, ATP (adenosine triphosphate) and 2,3-DPG (2,3-diphosphoglycerate), facilitate the release of oxygen from hemoglobin, the concentration of these compounds in the red cell may change in an attempt to compensate for any impairment in oxygen supply to tissue. We have observed elevated levels of red-cell 2,3-DPG and creatine in patients suffering from red-cell mass deficits and cardiopulmonary insufficiency; a significant correlation was noted between levels of red-cell 2,3-DPG and creatine. The mechanisms responsible for these elevations, however, are not known. Our data suggest that assays of the levels of peripheral red-cell 2,3-DPG and creatine constitute an excellent functional biopsy for evaluation of the state of tissue oxygenation. Such assays are useful for diagnosis and serial evaluation of therapy in patients with red-cell mass deficits and should be helpful in patients with cardiopulmonary disease.
Transbronchial Lung Biopsy Via the Fiberoptic Bronchoscope in Sarcoidosis
Authors: CLYDE H. KOONTZ
Journal: Annals of Internal Medicine (1976)

In a prospective study at two medical centers, 42 consecutive patients with suspected sarcoidosis underwent transbronchial lung biopsy during fiberoptic bronchoscopy. Transbronchial biopsy revealed noncaseating granulomas in 24 of the 38 cases (63%) in which adequate tissue was obtained. Special stains and cultures for acid-fast bacilli and fungi were negative, and sarcoidosis was subsequently diagnosed in all 42 cases. Positive biopsies were obtained in 11 of 20 patients with radiographic stage I disease, in 11 of 15 with stage II disease, and in 2 of 3 with stage III disease. There was a higher probability of a positive biopsy in patients with high symptom scores for cough, wheezing, and dyspnea, and in those with a vital capacity of < 80% of predicted. The only complication was one small pneumothorax, which spontaneously resolved. Transbronchial lung biopsy is an attractive initial procedure for obtaining histologic confirmation of sarcoidosis.
Treatment of Depression in the Elderly
Authors: Gary W. Small
Journal: JAMA (1983)

<h3>To the Editor.—</h3> When so notable a psychopharmacologist as Dr Uhlenhuth (1982;248:1879) discusses antidepressants, people listen. It is for this reason that I feel impelled to point out that physicians treating geriatric patients with depression need additional information not mentioned in Dr Uhlenhuth's editorial. First, recent studies<sup>1,2</sup>indicate that, in the geriatric population, response to tricyclic antidepressants occurs within the first week of treatment and predicts remission. Second, although benzodiazepines may be effective in treating the anxiety that often accompanies major depression, such beneficial effects are overshadowed by the risk of ataxia in the elderly. Moreover, these anxiolytics often accumulate in blood and other tissues of elderly patients, causing oversedation and worsening of depressive symptoms. Although antidepressants, too, are potentially toxic in the elderly, when prescribed in low doses with gradual increments, they are generally safe and effective. In situations complicated by concomitant illnesses, drug intolerance, or danger of
Study of plantar fasciitis treatment is flawed
Authors: J. Michelson
Journal: BMJ (2003)

EDITOR—Haake et al performed a multi-centre randomised controlled trial of extracorporeal shock wave treatment for plantar fasciitis.1 They say that their study is definitive and they therefore recommend against any further experimental testing of this treatment, but the study has sufficient methodological flaws to render their conclusions questionable. …
Uncommon Presentations of Non-Hodgkin’s Lymphoma
Authors: Hassan Pervez, Muhammed Shaikh, Anil Potti, Syed A. Mehdi
Journal: Journal of Clinical Oncology (2003)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.03.116 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12560452 Uncommon Presentations of Non-Hodgkin’s Lymphoma Case 3. Primary Renal Lymphoma Hassan PervezxHassan PervezSearch for articles by this author , Muhammed ShaikhxMuhammed ShaikhSearch for articles by this author , Anil PottixAnil PottiSearch for articles by this author , Syed A. MehdixSyed A. MehdiSearch for articles by this author Show More University of North Dakota School of Medicine and Health Sciences, Fargo, ND https://doi.org/10.1200/JCO.2003.03.116 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Giant Blood Cyst of the Pulmonary Valve
Authors: Grover J. Liese, Scott C. Brainard, Unoji Goto
Journal: New England Journal of Medicine (1963)

BLOOD cysts of the cardiac valves are rare in adults but have been reported as a moderately frequent post-mortem finding in infants below the age of six months.1 They are usually found on the mitral and tricuspid valves along the atrial surfaces, but also occur less commonly on the ventricular surfaces of the semilunar valves near the attachment of the cusps.2 Appearing as small, reddish nodules, 1 to 2 mm., they contain blood within a sac lined by endothelial cells.2 , 3 Although they have usually been described as post-mortem curiosities, they may, on rare occasions, cause a heart murmur.3 A few . . .
Paternally Inherited Inactivating Mutations of the<i>GNAS1</i>Gene in Progressive Osseous Heteroplasia
Authors: Eileen M. Shore, Jaimo Ahn, Suzanne Jan de Beur, Ming Li, Meiqi Xu, R.J. McKinlay Gardner, Michael A. Zasloff, Michael P. Whyte, Michael A. Levine, Frederick S. Kaplan
Journal: New England Journal of Medicine (2002)

Progressive osseous heteroplasia (POH), an autosomal dominant disorder, is characterized by extensive dermal ossification during childhood, followed by disabling and widespread heterotopic ossification of skeletal muscle and deep connective tissue. Occasional reports of mild heterotopic ossification in Albright's hereditary osteodystrophy (AHO) and a recent report of two patients with AHO who had atypically extensive heterotopic ossification suggested a common genetic basis for the two disorders. AHO is caused by heterozygous inactivating mutations in the GNAS1 gene that result in decreased expression or function of the alpha subunit of the stimulatory G protein (Gsα) of adenylyl cyclase.
The Extracranial–Intracranial Bypass Study
Authors: Sindey Goldring, Nicholas Zervas, Thomas Langfitt
Journal: New England Journal of Medicine (1987)

The Extracranial–Intracranial (EC-IC) Bypass Study was organized and conducted by Henry Barnett and colleagues at the University of Western Ontario and McMaster University under a grant from the National Institute of Neurological and Communicative Disorders and Stroke. Data were collected from 71 participating centers in North America, Europe, and Japan during the period 1977 to 1982. Patients eligible for the study were randomly assigned to medical and surgical arms, and outcomes were measured. Seven hundred fourteen patients were randomly assigned to medical care, and 663 patients to bypass surgery.The results were presented at the meeting of the World Federation . . .
Case finding in the elderly: does the primary care team already know enough?
Authors: J. Hooper
Journal: BMJ (1988)

The needs of an elderly population in one general practice were assessed by the primary health care team. A simple questionnaire was filled in as far as possible by members of the team on known social and functional criteria for each patient aged over 75. The questionnaire was complete for 100 of 118 elderly patients. The information was accurate for over 95% of the criteria as verified by information held by the health authority. This information will now be used for yearly reviews of each patient based on opportunistic contacts. This is a simple method of collating information that is already known. If such information was available to health authorities it would give them an idea of the type and extent of the support services needed for elderly people.
The “Evidence” Is In! It Does Get Better!
Authors: William T. Cefalu
Journal: Diabetes Care (2014)

With the January 2015 issue, our editorial team is now well past the halfway point of its tenure in overseeing the scientific aspects of Diabetes Care . Throughout the process, it has been our goal to keep you up to date and informed on our progress, initiatives, special issues, and thoughts. Specifically, in July 2014 (the actual midterm point of our tenure), our editorial team provided a very comprehensive and positive update, stating that we, as an editorial team, and Diabetes Care , as a journal, continue to evolve (1). We were also contemplating that at some future point (i.e., July 2015), we would still be asking, “Can it possibly get any better than this?” Though surprisingly earlier than expected, we believe this question has been answered in the affirmative. We feel the level of articles we publish that report data from scientific investigation and innovative medical care and treatments continues to be extremely high as exemplified by articles in this issue of Diabetes Care . Specifically, given the changing evidence base of studies, there is steady progress being made in the form of updated recommendations for management of hyperglycemia. In addition, there are now data providing more validation of the recommended American Diabetes Association (ADA) Standards of Care for management of diabetes.

At this point in time, there is no need to restate the changes we made to the journal or the initiatives put in place over the last 2.5 years. These have been adequately covered in prior Editorials. However, the initiatives put in place continue to grow and expand.

For example, our signature event at the ADA Scientific Sessions has been our Diabetes Care Symposium (we recently held our 3rd Annual Symposium in June 2014). This year we experimented with the format of the symposium by dividing it …
Martin John Wood
Authors: C. Ellis
Journal: BMJ (2003)

Consultant physician Birmingham Heartlands Hospital (b Leicester 1945; q Oxford/St Mary's Hospital, London, 1970), died from a heart attack on 15 December 2002.​2002.




Figure 1




Martin applied his considerable intellect to the treatment of infection at a time when emphasis was changing from antibacterials to antivirals and he became an international authority on the management of herpes virus infections. He edited the Journal of Antimicrobial Chemotherapy from 1995 to 2000 and became president of the British Society of Antimicrobial Chemotherapy. He leaves a wife, Stephanie, and two sons.
Myasthenia Gravis and Lymphoma
Authors: Stephen Davis
Journal: JAMA (1979)

Myasthenia gravis and lymphoma rarely coexist, but the occurrence of myasthenia shortly after the treatment of a patient with poorly differentiated nodular lymphoma suggested that an immunological disorder may have contributed to the development of both diseases; the fundamental defects in this association may be impaired immunological surveillance and impaired regulation of immune responses to autoantigens. The finding of T-cell immunodeificiency, including profound T-cell lymphopenia, impaired delayed hypersensitivity responses, and failure to a thymus-dependent antibody response to Salmonella adelaide flagellin, is consistent with this hypothesis.
Identification of Hypoxic Regions in Traumatic Brain Injury
Authors: SOBHAN VINJAMURI, KIERAN O’DRISCOLL, PAUL MALTBY, ANTHONY J. McEWAN, LEONARD I. WIEBE, MAN CRITCHLEY
Journal: Clinical Nuclear Medicine (1999)

Because perfusion brain SPECT provides images with low resolution and MRI identifies only structural changes, these two tests routinely applied in a clinical setting may not identify all injuries in the brain after closed head trauma. In this case, I-123 iodoazomycin arabinoside showed that a patient had a hypoxic brain injury even though the findings of both perfusion SPECT and MRI were normal. Although the patient was clinically and neurologically normal, neuropsychological testing revealed abnormal cognitive function. All the investigations were conducted in the subacute phase of traumatic brain injury (approximately 6 months after initial trauma). The patient was selected for intensive rehabilitation therapy. The scores of cognitive function returned to normal when assessments were repeated 12 months after trauma. In conclusion, a normal result of perfusion brain SPECT does not exclude hypoxic brain injury.
Rapid Gastric Emptying of a Solid Pancake Meal in Type II Diabetic Patients
Authors: Joyce G Schwartz, Gary M Green, Difu Guan, C Alex McMahan, William T Phillips
Journal: Diabetes Care (1996)

OBJECTIVE To estimate the rate of gastric emptying of a solid pancake carbohydrate meal in recently diagnosed asymptomatic type II diabetic patients compared with nondiabetic control subjects. RESEARCH DESIGN AND METHODS Gastric emptying studies using radiolabeled meals were performed on eight recently diagnosed asymptomatic diabetic patients and on eight sex-, BMI- and age-matched nondiabetic control subjects. Although a liquid protein drink was administered along with the pancake meal, the radioactivity was adherent to only the pancake portion of the meal. Plasma glucose and serum insulin levels were measured in fasting and postprandial blood samples collected at 15-min intervals up to 120 min after ingestion of the mixed nutrient meal. RESULTS The average gastric half-emptying time (time it takes for one-half of the meal to empty) was significantly more rapid for the diabetic patients (45.3 ± 4.8 min) when compared with the nondiabetic control subjects (60.4 ± 5.1 min; P = 0.05). The serum insulin concentrations were not statistically different between the two groups. Plasma glucose values were significantly higher in the diabetic patients compared with the nondiabetic control subjects. CONCLUSIONS Type II diabetic patients with no clinical evidence of neuronal dysfunction have a significantly more rapid rate of gastric emptying of a solid high-carbohydrate meal when compared with nondiabetic control subjects.
Who Has Diabetes? Best Estimates of Diabetes Prevalence in the Department of Veterans Affairs Based on Computerized Patient Data
Authors: Donald R. Miller, Monika M. Safford, Leonard M. Pogach
Journal: Diabetes Care (2004)

OBJECTIVE—To optimize methods for identifying patients with diabetes based on computerized records and to obtain best estimates of diabetes prevalence in Department of Veterans Affairs (VA) patients. RESEARCH DESIGN AND METHODS—The VA Diabetes Epidemiology Cohort (DEpiC) is a linked national database of all VA patients since 1998 with data from VA medical visits, Medicare claims, pharmacy and laboratory records, and patient surveys. Using DEpiC, we examined concordance of diabetes indicators, including ICD-9-CM codes (250.xx), prescription drug treatment, HbA1c tests, and patient self-report. We determined the optimal criterion for identifying diabetes and used it in estimating diabetes prevalence in the VA. RESULTS—The best criterion was a prescription for a diabetes medication in the current year and/or 2+ diabetes codes from inpatient and/or outpatient visits (VA and Medicare) over a 24-month period. This definition had high sensitivity (93%) and specificity (98%) against patient self-report, and reasonable rates of HbA1c testing (75%). HbA1c testing alone added few additional cases, and a single diagnostic code added many patients, but without confirmation (reduced specificity). However, including codes from Medicare was critical. Applying this definition for 1998–2000, we identified an average of 500,000 VA patients with diabetes per year. We also estimated high and increasing diabetes prevalence rates of 16.7% in FY1998, 18.6% in FY1999, and 19.6% in FY2000 and an incidence estimated to be ∼2% per year. CONCLUSIONS—Development and evaluation of methodology for analyzing computerized patient data can improve the identification of patients with diabetes. The increasing high prevalence of diabetes in VA patients will present challenges for clinicians and health system management.
Islet Autotransplantation Restores Normal Glucose Tolerance in a Patient With Chronic Pancreatitis
Authors: Severine Illouz, M'Balu Webb, Cristina Pollard, Patrick Musto, Kieran O'Reilly, David Berry, Ashley Dennison
Journal: Diabetes Care (2007)

Impaired glucose tolerance is a frequent complication of chronic pancreatitis (CP) that over time leads to diabetes (1). Intractable abdominal pain from CP that can no longer be managed by oral pancreatic enzymes and by narcotic analgesics is treated by surgery. To avoid diabetes onset following pancreatectomy, combined islet autotransplantation has been offered to the patients who suffered from CP in Leicester, U.K., since 1994 (2,3) (http://hpb.org.uk/hpbunitspecialist.php?page_id=11).

Here, we present a case report of a patient that suffered from CP and had an abnormal oral glucose tolerance test (OGTT) …
Family Therapy in the Treatment of Anorexia Nervosa
Authors: AVNER BARCAI
Journal: American Journal of Psychiatry (1971)

The author presents a technique for rapid, continuous weight gain in patients suffering from anorexia nervosa, a syndrome often highly refractory to therapy. In two cases, crisis-induced family therapy enabled the family to change its habitual interaction patterns, thus freeing the patient to regain her original weight. Patients' small, regular weight gains allowed therapy to proceed without the threat of food refusal potentially handicapping the therapeutic process. Some of the dangers and advantages inherent in this approach are reported.
Lipid Levels in Former Gestational Diabetic Mothers
Authors: Cynthia H Meyers-Seifer, Betty R Vohr
Journal: Diabetes Care (1996)

OBJECTIVE To investigate lipid levels in former gestational diabetic mothers, 5–6 years postpartum, and to evaluate the relationship of these values to glucose, insulin, BMI, and blood pressure. RESEARCH DESIGN AND METHODS The subjects studied were 56 former gestational diabetic mothers and 48 control mothers 5–6 years postpartum. Two hours after a 50-g carbohydrate meal, total cholesterol (TC), triglycerides (TG), HDL and LDL cholesterol, glucose, and insulin were measured and compared between the two groups (analysis of variance). BMI and blood pressure were also evaluated. The risk of finding an abnormal metabolic, anthropometric, or hemodynamic parameter in either group was assessed (X2 analysis and Fisher's exact test). Correlation coefficients were assessed between the lipids versus insulin, glucose, BMI, and blood pressure. RESULTS Mean TC, TG, LDL cholesterol, glucose, and systolic blood pressure were significantly higher in the gestational diabetic mothers than in the control mothers. In addition, there was greater likelihood of finding an abnormal TC ≥ 5.17 mmol/l, LDL cholesterol ≥ 4.14 mmol/l, and systolic blood pressure &amp;gt; 140 mmHg in gestational diabetic mothers. Triglycerides correlated with BMI, insulin, systolic and diastolic blood pressure, and HDL cholesterol correlated inversely with insulin in gestational diabetic mothers. CONCLUSIONS We conclude that at 5–6 years postpartum, former gestational diabetic mothers demonstrate changes in lipid levels that differ from control mothers and that specific lipids correlate with cardiovascular risk factors. Further study is needed to evaluate gestational diabetic mothers for the development of cardiovascular risk factors including insulin resistance.
Propranolol and Labeling
Authors: HUGH H. HUSSEY
Journal: Annals of Internal Medicine (1973)

Comments1 October 1973Propranolol and LabelingHUGH H. HUSSEY, M.D., JOHN D. ARCHER, M.D.HUGH H. HUSSEY, M.D.Search for more papers by this author, JOHN D. ARCHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-4-608 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article, "Propranolol," by Dr. Howard F. Morrelli (1) discusses defects in the manufacturer's package brochure for that drug in the context of its approval by the Food and Drug Administration (FDA). Although we could argue with scattered implications in the text, we acknowledge that, overall, it was a masterful dissection of the obsolete quality of the brochure. Nevertheless, a passage in the article's abstract is so disturbing that we feel compelled to comment—notwithstanding some discomfort, as editors of one medical journal in criticizing the content of another journal.Dr. Morrelli cites the uses of propranolol...References1. MORRELLI F: Propranolol. Ann Intern Med 78:913-917, 1973 LinkGoogle Scholar2. SIMMONS H: Investigational exemption procedures for new drugs (letter). JAMA 213:1902-1904, 1970 CrossrefMedlineGoogle Scholar3. ARCHER J: Instrument or impediment? The regulatory monograph in medical communications. JAMA 220:1474-1477, 1972 CrossrefMedlineGoogle Scholar4. ARCHER J: Eternal vigilance—the price of liberty (editorial). JAMA 222:1553-1555, 1972 CrossrefMedlineGoogle Scholar5. MARTINEAU P: Methylprednisolone for sunburn, FDA and package insert notwithstanding? Answer by ARCHER JD (questions and answers). JAMA 225:72, 1973 Google Scholar1. PICKERING G: Clinical problems and results, in Conference on Controlled Clinical Trials. Oxford, Blackwell Scientific Publications, 1960, p. 165 Google Scholar1. ALLISONCHAMBERLAINMILLER SMJ: Effects of propranolol on blood sugar, insulin, and free fatty acids. Diabetologia 5:339-342, 1969 CrossrefMedlineGoogle Scholar2. KOTLERBERMANRUBENSTEIN MLA: Hypoglycemia precipitated by propranolol. Lancet 2:1389-1390, 1966 CrossrefMedlineGoogle Scholar3. DEDIVITIISGIORDANOGALLO OFB: Tolbutamide and propranolol. Lancet 1:749, 1968 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HUGH H. HUSSEY, M.D.; JOHN D. ARCHER, M.D.Affiliations: The Journal of the American Medical Association Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1973Volume 79, Issue 4Page: 608-609 ePublished: 13 March 2020 Issue Published: 1 October 1973 PDF downloadLoading ...