tbuckley/cabot-search huggingface dataset:
Geoffrey David Ward
Authors: M. F. B. Grundy
Journal: BMJ (2010)

Geoffrey David Ward (“Geoff”) was born on 30 July 1940 in Brisbane. His father became the chief auditor to the Australian High Commission in London in 1956, and the family moved to Surbiton. He completed his education at Tiffin School, where he became head boy, and graduated at University College Hospital, London, in 1964, where he had previously been elected president of UCL Medical Society and later captain of UCH rugby.

After qualifying, he did house jobs at UCH, then obstetrics and gynaecology at Hackney and Westminster before registrar posts at St Mary’s Harrow Road and Slough, …
Myocardial contraction and hyaluronic acid mechanotransduction in epithelial-to-mesenchymal transformation of endocardial cells
Authors: Mary Kathryn Sewell-Loftin, Daniel M. DeLaughter, Jon R. Peacock, Christopher B. Brown, H. Scott Baldwin, Joey V. Barnett, W. David Merryman
Journal: Biomaterials (2014)
Megestrol for AIDS-Related Anorexia
Authors: David C. Hodgson
Journal: Annals of Internal Medicine (1995)

Letters1 June 1995Megestrol for AIDS-Related AnorexiaDavid C. Hodgson and Donald A. RedelmeierDavid C. HodgsonSearch for more papers by this author and Donald A. RedelmeierSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-11-199506010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Von Roenn and colleagues' provocative study [1] examined the effects of megestrol acetate in patients with the acquired immunodeficiency syndrome (AIDS). Perhaps the most important clinical observation was that increased body weight correlated strongly with improved patient perceptions of well-being. The most striking research finding, however, was not discussed, namely, that the distribution of weight gains was identical to the distribution of psychological gains. Although we would like to believe that this finding is due to the harmonious marriage of mind and body among study patients, we suspect it may simply represent a layout error.REFERENCE1. Von Roenn JH, Armstrong D, Kotler DP, Cohn DL, Klimas NG, Teheckmedyian NS, et al. Megestrol acetate in patients with AIDS-related cachexia. Ann Intern Med. 1994; 121:393-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1995Volume 122, Issue 11Page: 879-881KeywordsAIDSBody weightPerceptionWeight gain ePublished: 15 August 2000 Issue Published: 1 June 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats.
Authors: D E Wesson
Journal: Journal of Clinical Investigation (1997)

We examined if endogenous endothelins mediate the decreased HCO3 secretion and increased H+ secretion in in vivo-perfused distal tubules of rats fed dietary acid as (NH4)2SO4. Animals given (NH4)2SO4 drinking solution had higher endothelin-1 addition to renal interstitial fluid than those given distilled H2O (480+/-51 vs. 293+/-32 fmol g kidney wt(-1) min(-1), respectively, P < 0.03). (NH4)2SO4-ingesting animals infused with bosentan (10 mg/kg) to inhibit A- and B-type endothelin receptors had higher HCO3 secretion than baseline (NH4)2SO4 animals (-4.7+/-0.4 vs. -2.4+/-0.3 pmol mm(-1) min(-1), P < 0.01), but (NH4)2SO4 animals given a specific inhibitor of A-type endothelin receptors (BQ-123) did not (-2.0+/-0.2 pmol mm(-1) min(-1), P = NS vs. baseline). H+ secretion was lower in bosentan-infused compared with baseline (NH4)2SO4 animals (27.7+/-2.5 vs. 43.9+/-4.0 pmol mm(-1) min(-1), P < 0.03), but that for BQ-123-infused (NH4)2SO4 animals was not (42.9+/-4.2 pmol mm(-1) min(-1), P = NS vs. baseline). Bosentan had no effect on distal tubule HCO3 or H+ secretion in control animals. The data show that dietary acid increases endothelin-1 addition to renal interstitial fluid and that inhibition of B- but not A-type endothelin receptors blunts the decreased HCO3 secretion and increased H+ secretion in the distal tubule of animals given dietary acid. The data are consistent with endogenous endothelins as mediators of increased distal tubule acidification induced by dietary acid.
Triple-negative breast cancer and obesity in a rural Appalachian population.
Authors: L Vona-Davis, DP Rose, H Hazard, J Partin, F Adkins, G Hobbs
Journal: Cancer Research (2009)

Abstract Abstract #6099 Background: Our objective was to determine the clinico-pathological features of triple-negative (estrogen, progesterone and HER-2 receptor negative) breast cancer and their relationship to obesity in women drawn from a population with one of the highest obesity rates in the United States.&amp;#x2028; Methods: This retrospective study involved 620 white patients with invasive breast cancer in West Virginia. Hospital tumor registry, charts, and pathology records provided age at diagnosis, tumor histologic type, size, and nodal status, and receptor status. Body mass index (BMI) was calculated and a value of ≥30 considered indicative of obesity.&amp;#x2028; Results: Triple-negative tumors occurred in 117 (18.9%) of the 620 patients, most often in association with invasive ductal carcinomas. Patients with triple-negative tumors were younger than those with other receptor types, 44.5% and 26.7%, respectively, being diagnosed before age 50 years (P = 0.0004). The triple-negative tumors were larger (P = 0.0003), most notably in the younger women, but small tumors (&amp;lt;2.0 cm) were more often accompanied by lymph node metastases. Obesity was present in 49.6% of those with triple-negative tumors, but only 35.8% of those with non-triple-negative tumors (P = 0.0098). Lymph node metastases were more frequently associated with T2 tumors in obese patients (P = 0.032) regardless of their receptor status.&amp;#x2028; Conclusions: Triple-negative breast cancers within a white, socioeconomically-deprived, population occurred in younger women, with later stage at diagnosis, and in association with obesity. The elevated adipokine production which is present in obesity may exert tumor proliferative and angiogenic effects that contribute to an aggressive phenotype. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6099.
DIFFERENTIATION OF T-CELL PRECURSORS IN NUDE MICE DEMONSTRATED BY IMMUNOFLUORESCENCE OF T-CELL MEMBRANE MARKERS
Authors: F. Loor, B. Kindred
Journal: The Journal of Experimental Medicine (1973)

When the thymus from an AKR mouse (TL(-), theta-AKR) is grafted to a BALB/c-nu/nu mouse (TL2, theta-C3H), the grafted thymus is rapidly repopulated by host lymphocytes, i.e., lymphocytes having the TL2 and theta-C3H T-lymphocyte membrane antigen markers. theta-C3H lymphocytes also appear rapidly in the spleen and lymph nodes. After a few weeks, BALB/c nude mice grafted with AKR thymus and normal BALB/c mice could not be distinguished on the basis of the number of TL-positive thymocytes or theta-C3H-positive lymphocytes in thymus, spleen, or lymph nodes. These experiments give a definitive proof of the existence of precursor cells for the T compartment of the lymphoid system in the nude mouse. They strongly suggest the involvement of host-derived T cells in the recovery of some T-cell functions by nude mice grafted with allogeneic thymuses.
Anchoring interferon alpha to apolipoprotein A‐I reduces hematological toxicity while enhancing immunostimulatory properties
Authors: Jessica Fioravanti, Iranzu González, José Medina-Echeverz, Esther Larrea, Nuria Ardaiz, Gloria González-Aseguinolaza, Jesús Prieto, Pedro Berraondo
Journal: Hepatology (2011)

Interferon alpha (IFNα) is widely used for the treatment of viral hepatitis but substantial toxicity hampers its clinical use. In this work, we aimed at improving the efficacy of IFNα therapy by increasing the IFNα half-life and providing liver tropism. We selected apolipoprotein A-I (ApoA-I) as the stabilizing and targeting moiety. We generated plasmids encoding IFNα, albumin bound to IFNα (ALF), or IFNα linked to ApoA-I (IA) and mice were treated either by hydrodynamic administration of the plasmids or by injection of the corresponding recombinant proteins or high-density lipoproteins containing IA. The plasma half-life of IA was intermediate between IFNα and ALF. IA was targeted to the liver and induced higher hepatic expression of interferon-stimulated genes than IFNα or even ALF. IA exhibits stronger in vivo antiviral activity than IFNα and the hematologic cytopenic effects of IA are milder than those observed when using IFNα or ALF. In contrast to IFNα, IA does not cause activation-dependent cell death of lymphocytes in vitro. Accordingly, in vivo studies showed that IA boosts T-cell immune responses more efficiently than IFNα or ALF. The difference in immunostimulatory activity between IFNα and IA disappears in scavenger receptor class B type I (SR-BI) knockout mice, suggesting that crosstalk between SR-BI and IFNα receptor is essential for enhanced induction of cytotoxic T cells by IA. Conclusion: Anchoring IFNα to ApoA-I prolongs the half-life of IFNα and promotes targeting to the liver. Importantly, the fusion protein shows increased immunostimulatory properties and lower hematological toxicity. (HEPATOLOGY 2011;)
Mismatched Perfusion Defects Secondary to Recent Methyl Methacrylate Embolization
Authors: Garima Agrawal, Chadwick L. Wright, Nicholas G. Rhodes, Akash Sharma
Journal: Clinical Nuclear Medicine (2012)

Methyl methacrylate (MMA) pulmonary embolism is a serious potential complication of percutaneous vertebroplasty. We present a case of a 28-year-old man who presented to an outside institution with pleuritic chest pain after MMA vertebroplasty of the T11 thoracic vertebra for chronic back ache secondary to a previous traumatic fracture. Multifocal MMA pulmonary embolism was identified on CT. The patient was referred to our institution following a wedge resection for pulmonary infarction. V/Q scintigraphy was performed and demonstrated normal ventilation with multiple mismatched perfusion defects bilaterally. Patient subsequently underwent central and bilateral segmental pulmonary embolectomies.
Regional Correlation of Structure and Function in Glaucoma, Using the Disc Damage Likelihood Scale, Heidelberg Retina Tomograph, and Visual Fields
Authors: Helen V. Danesh-Meyer, Judy Y.F. Ku, Taras L. Papchenko, Thiran Jayasundera, John C. Hsiang, Greg D. Gamble
Journal: Ophthalmology (2006)
Gastric studies in sjogren's syndrome.
Authors: W W Buchanan, A G Cox, R M Harden, A I Glen, J R Anderson, K G Gray
Journal: Gut (1966)

<b>Objective.</b> To examine the relationship between the Pharmacy Curriculum Outcomes Assessment (PCOA) and the North American Pharmacist Licensure Examination (NAPLEX) using a large, multi-institutional sample of student scores. <b>Methods.</b> A matched dataset was obtained from the National Association of Boards of Pharmacy (NABP) consisting of examination scores for the 1,460 students who completed both the PCOA and the NAPLEX between 2012 and 2015 at six schools/colleges of pharmacy (S/COPs). Bivariate correlations were estimated for total and content area scores on both examinations. Students’ total NAPLEX scores were predicted using linear regression models containing total and content area scores on PCOA and dummy variables for S/COP and year. <b>Results.</b> Students’ PCOA total score and NAPLEX total score were significantly and moderately correlated (<i>r</i>=0.54). All correlations between PCOA and NAPLEX total and content area scores were significant. and ranged from <i>r</i>=0.22 to 0.56. Regression results showed pharmaceutical and clinical sciences PCOA content scores were significant predictors of NAPLEX total score while basic biomedical sciences and social/behavioral/administrative sciences were not. The PCOA total and content scores accounted for 30%-33% of the variance in total NAPLEX score. <b>Conclusion.</b> Student PCOA and NAPLEX total and content area scores were significantly correlated, which is consistent with the findings of previous research. The somewhat modest proportion of variance in NAPLEX scores accounted for by PCOA scores illustrates the need for use of additional performance measures when evaluating student preparedness for the NAPLEX. This study provides important baseline data that can be used by S/COPs for comparison with their own student data as well as by researchers seeking to conduct additional analyses following recent changes in the PCOA and NAPLEX blueprints.
Parthenolide, a Sesquiterpene Lactone From the Medicinal Plant, Feverfew, Inhibits IκB kinase, Nuclear Factor-κB activation and Inflammatory response in CF cell lines and Mice
Authors: A. Saadane, S. Masters, J. DiDonato, J. Li, M. Berger
Journal: Journal of Allergy and Clinical Immunology (2007)
Hospital Admission Through the Emergency Department-Reply
Authors: Carin M. Olson
Journal: JAMA (1992)

<h3>In Reply.</h3> —I congratulate Dr Tachakra and colleagues and their medical students for devising adjustments to account for the extended hospital stays seen among patients admitted through EDs. Lack of support services for patients after hospital discharge lengthens hospital stays, and inclusion of a "disability" factor makes sense. I am somewhat surprised that the recover-ability factor was useful, as the diagnosis related group scale used by Stern et al<sup>1</sup>to account for severity of illness includes comorbidities. The additional time and tests needed to familiarize care givers with patients admitted through EDs and the inability to use preadmission testing or to coordinate in-hospital management are other factors thought to influence the cost and duration of care for such patients.<sup>1-3</sup> Dr Hoffman describes providing facilities as alternatives to EDs for patients without urgent health problems. This would certainly ameliorate the problem of ED overcrowding, as 11% to 15% of visits
Topical amorolfine for 15 months combined with 12 weeks of oral terbinafine, a cost-effective treatment for onychomycosis
Authors: R. Baran
Journal: British Journal of Dermatology (2008)

This open randomized study examined the efficacy of a combination of oral terbinafine and topical amorolfine in the treatment of severe dermatophyte toenail onychomycosis with matrix area involvement.A total of 147 patients were randomized to one of three treatment groups: 15 months of once-weekly topical amorolfine lacquer in combination with 6 weeks (Group AT6) or 12 weeks (Group AT12) of oral terbinafine, 250 mg once daily: or terbinafine monotherapy for 12 weeks (Group T12). Patients were followed for a total of 18 months. The primary efficacy variable was the result of mycological examination after 3 months of therapy; secondary efficacy variables were mycological and clinical examination at 3-monthly intervals, with an additional clinical evaluation at 18 months. Safety and tolerance were also assessed.Negative mycological results, assessed at 3 months, were recorded for 14 of 40 patients (35%) in Group AT6, 11 of 44 (27.5%) in Group AT12 and 7 of 41 (17.1%) in Group T12. At 18 months, the global response (mycological and clinical cure) was seen in 22 of 50 patients (44%), 34 of 47 (72.3% and 18 of 48 (37.5%) in the AT6, AT12 and T12 groups, respectively.These results suggest that a combination therapy regime with oral and systemic treatment is superior in efficacy to monotherapy with a systemic drug alone in the treatment of severe onychomycosis. In addition, the cost per cure ratio was better in the combination groups.
Intense Gallium-67 Uptake in Ovarian Dysgerminoma
Authors: TERUHIKO TAKAYAMA, JUNICHI TAKI, TAMIO ABURANO, NORIHISA TONAMI, KINICHI HISADA, TOSHINOBU NAKAGAWA
Journal: Clinical Nuclear Medicine (1993)

In a patient with an ovarian dysgerminoma, intense up-take of gallium-67 citrate was demonstrated. This report indicates that dysgerminoma should be added to the list showing abnormal accumulation of gallium-67 citrate in the abdomen.
Suppression of post-angioplasty restenosis with an Akt1 siRNA-embedded coronary stent in a rabbit model
Authors: Hui-Lian Che, In-Ho Bae, Kyung Seob Lim, In Taek Song, Haeshin Lee, Muthunarayanan Muthiah, Ran Namgung, Won Jong Kim, Dong-Gon Kim, Youngkeun Ahn, Myung-Ho Jeong, In-Kyu Park
Journal: Biomaterials (2012)
COMPLETE RESTORATION OF FUNCTION OF TORN SPHINCTER ANI MUSCLE AFTER 23 YEARS OF ATROPHY AND DISUSE.
Authors: ROBERT H. M. DAWBARN
Journal: JAMA (1907)

The accusation is sometimes made that surgeons who have had the good luck to score an exceptional success are apt to rush into print and report it to the profession without waiting a reasonable time in which to ascertain whether or not the cure can properly be classed as a permanent one. However, I think we may consider the following patient definitely and permanently cured, whose case—possibly unique in point of time between her sphincteric loss and its restoration—I now publish for the first time six years after the operation. My library search has not been thorough, and reports from those who have completely cured patients longer afflicted would be of interest. The patient, a lady in the family of a physician in this city, states that she can now control, even during an occasional diarrhea, her bowel movements as perfectly as ever before the tear. If this muscle, during
Clinical Research in Australia
Authors: BARRY G. FIRKIN
Journal: Annals of Internal Medicine (1974)

Abroad1 October 1974Clinical Research in AustraliaBARRY G. FIRKIN, M.D.BARRY G. FIRKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-4-552 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the field of clinical investigation Australia is still a developing country. The lack of local facilities forces young Australian graduates to go to the United States or Europe to complete their training in many areas of medical science. Although job opportunities for academics are increasing, they are still relatively scarce and often bedeviled by heavy administrative and service commitments that leave little time for research. Some historical background is necessary to understand the belated entrance of clinical investigation on the Australian medical scene and the current struggle to put it on a firm foundation.The first fleet arrived in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Monash Medical School Alfred Hospital Prahran, Victoria, Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1974Volume 81, Issue 4Page: 552-553KeywordsGraduate medical education Issue Published: 1 October 1974 PDF DownloadLoading ...
Accuracy of real-time shear wave elastography for assessing liver fibrosis in chronic hepatitis C: A pilot study
Authors: Giovanna Ferraioli, Carmine Tinelli, Barbara Dal Bello, Mabel Zicchetti, Gaetano Filice, Carlo Filice
Journal: Hepatology (2012)

Real-time shear wave elastography (SWE) is a novel, noninvasive method to assess liver fibrosis by measuring liver stiffness. This single-center study was conducted to assess the accuracy of SWE in patients with chronic hepatitis C (CHC), in comparison with transient elastography (TE), by using liver biopsy (LB) as the reference standard. Consecutive patients with CHC scheduled for LB by referring physicians were studied. One hundred and twenty-one patients met inclusion criteria. On the same day, real-time SWE using the ultrasound (US) system, Aixplorer (SuperSonic Imagine S.A., Aix-en-Provence, France), TE using FibroScan (Echosens, Paris, France), and US-assisted LB were consecutively performed. Fibrosis was staged according to the METAVIR scoring system. Analyses of receiver operating characteristic (ROC) curve were performed to calculate optimal area under the ROC curve (AUROC) for F0-F1 versus F2-F4, F0- F2 versus F3-F4, and F0-F3 versus F4 for both real-time SWE and TE. Liver stiffness values increased in parallel with degree of liver fibrosis, both with SWE and TE. AUROCs were 0.92 (95% confidence interval [CI]: 0.85-0.96) for SWE and 0.84 (95% CI: 0.76-0.90) for TE (P = 0.002), 0.98 (95% CI: 0.94-1.00) for SWE and 0.96 (95% CI: 0.90-0.99) for TE (P = 0.14), and 0.98 (95% CI: 0.93-1.00) for SWE and 0.96 (95% CI: 0.91-0.99) for TE (P = 0.48), when comparing F0-F1 versus F2- F4, F0- F2 versus F3-F4, and F0 -F3 versus F4, respectively.The results of this study show that real-time SWE is more accurate than TE in assessing significant fibrosis (≥ F2). With respect to TE, SWE has the advantage of imaging liver stiffness in real time while guided by a B-mode image. Thus, the region of measurement can be guided with both anatomical and tissue stiffness information.
Insane Wards in General Hospitals.
Authors: Theodore Diller
Journal: JAMA (1905)

Pittsburg, Pa., Jan. 27, 1905. <h3>To the Editor:</h3> —In his interesting description of the new City Hospital of Nuremburg,<sup>1</sup>Dr. Barker mentions that 31 of its 946 beds are allotted to insane patients. One could wish that he had furnished some information as to just how this division of the hospital is equipped and how it is managed, for, in my opinion, the attempt to treat disease which exhibits "insanity" as a symptom or group of symptoms in a general hospital marks a distinct step in advance. It is an effort to follow out in practice the theory that "insanity" is a manifestation of sickness, as is headache or edema or convulsions or vomiting or paralysis, dependent, like any of these symptoms, on underlying bodily alterations. To treat "insanity" in a general hospital is an object lesson, to the profession and laity alike, of immense value. In no other
Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis.
Authors: M Y Choy, J A Walker-Smith, C B Williams, T T MacDonald
Journal: Gut (1990)

Many interleukin-2 receptor (CD25) bearing cells can be identified by alkaline phosphatase immunohistochemistry in the diseased intestinal lamina propria of children with Crohn9s disease or ulcerative colitis, but rarely in normal intestine. In both diseases, the CD25+ cells are present as aggregates in the lamina propria below the epithelium, and constitute a large proportion of the lamina propria mononuclear cells. In Crohn9s disease, but not ulcerative colitis, CD25+ cells are abundant in the submucosa. The CD25+ cells in Crohn9s disease are 58-88% CD3+, CD4+, CD8-, indicating that they are T cells, whereas in ulcerative colitis the CD25+ cells are greater than 80% CD3-, CD4+, HLA-DR+, indicating that they are macrophages. Thus, differential expression of CD25 on T cells and macrophages serves to distinguish the immunologic lesions in ulcerative colitis and Crohn9s disease.