β-Cell Regeneration in a Patient with Type 1 Diabetes Mellitus Who Was Receiving Immunosuppressive Therapy
Authors: Akio Kuroda
Journal: Annals of Internal Medicine (2003)

Letters18 November 2003β-Cell Regeneration in a Patient with Type 1 Diabetes Mellitus Who Was Receiving Immunosuppressive TherapyAkio Kuroda, MD, PhD, Yoshimitsu Yamasaki, MD, PhD, and Akihisa Imagawa, MD, PhDAkio Kuroda, MD, PhDFrom Osaka University Graduate School of Medicine, Suita Osaka 565-0871, Japan; and Osaka Medical College, Takatsuki 569-8686, Japan.Search for more papers by this author, Yoshimitsu Yamasaki, MD, PhDFrom Osaka University Graduate School of Medicine, Suita Osaka 565-0871, Japan; and Osaka Medical College, Takatsuki 569-8686, Japan.Search for more papers by this author, and Akihisa Imagawa, MD, PhDFrom Osaka University Graduate School of Medicine, Suita Osaka 565-0871, Japan; and Osaka Medical College, Takatsuki 569-8686, Japan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-10-200311180-00030-w1 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: The major cause of type 1 diabetes mellitus is the chronic autoimmune destruction of β-cells, which is mainly mediated by T cells. The destruction begins before the onset of clinical symptoms and continues afterward (1). The recurrence of type 1 diabetes mellitus, accompanied by antiglutamic acid decarboxylase antibody, can be observed even in a patient with a transplanted pancreas when the immunosuppression is insufficient (2).Objective: To investigate whether β-cell regeneration was occurring in the native pancreas of a patient receiving immunosuppressive therapy after simultaneous pancreaskidney transplantation.Case Report: A 32-year-old man who had a 19-year ...References1. Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet. 2001;358:221-9. [PMID: 11476858] CrossrefMedlineGoogle Scholar2. Petruzzo P, Andreelli F, McGregor B, Lefrancois N, Dawahra M, Feitosa LC, . Evidence of recurrent type I diabetes following HLA-mismatched pancreas transplantation. Diabetes Metab. 2000;26:215-8. [PMID: 10880896] MedlineGoogle Scholar3. Imagawa A, Hanafusa T, Tamura S, Moriwaki M, Itoh N, Yamamoto K, . Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological evidence of cellular autoimmunity. Diabetes. 2001;50:1269-73. [PMID: 11375326] CrossrefMedlineGoogle Scholar4. Fernandes A, King LC, Guz Y, Stein R, Wright CV, Teitelman G. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology. 1997;138:1750-62. [PMID: 9075740] CrossrefMedlineGoogle Scholar5. Waguri M, Hanafusa T, Itoh N, Miyagawa J, Imagawa A, Kuwajima M, . Histopathologic study of the pancreas shows a characteristic lymphocytic infiltration in Japanese patients with IDDM. Endocr J. 1997;44:23-33. [PMID: 9152611] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Akio Kuroda, MD, PhD; Yoshimitsu Yamasaki, MD, PhD; Akihisa Imagawa, MD, PhDAffiliations: From Osaka University Graduate School of Medicine, Suita Osaka 565-0871, Japan; and Osaka Medical College, Takatsuki 569-8686, Japan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReprogramming—Evolving Path to Functional Surrogate β-CellsPredominance of β-Cell Neogenesis Rather Than Replication in Humans With an Impaired Glucose Tolerance and Newly Diagnosed DiabetesBeta cell function during rapamycin monotherapy in long-term type 1 diabetesEffects of Exenatide Alone and in Combination With Daclizumab on β-Cell Function in Long-Standing Type 1 DiabetesPancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograftRegeneration of β Cells in the Native Pancreata After Syngeneic and Allogeneic Pancreas Transplantations in Spontaneously Type 2 Diabetic Torii RatsPotencial role of stem cell therapy in type 1 diabetes mellitusIslet Cell TransplantationAutologous stem cell transplantation for early type 1 diabetes mellitusβ-cell regeneration to treat Type 1 diabetes mellitusType 1 Diabetes and Glucose MonitoringThe Potential for Stem Cell Therapy in DiabetesRoutes to regenerating islet cells: stem cells and other biological therapies for type 1 diabetes 18 November 2003Volume 139, Issue 10Page: W-81KeywordsAbdominal surgeryBiopsyCellsImmunosuppressivesInsulinPancreasRegenerative medicineT cellsTransplantationType 1 diabetes ePublished: 18 November 2003 Issue Published: 18 November 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...