tbuckley/cabot-search huggingface dataset:
Immunophenotyping of eosinophils recovered from blood and BAL of allergic asthmatics.
Authors: H J Mengelers, T Maikoe, L Brinkman, B Hooibrink, J W Lammers, L Koenderman
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Studies of bronchoalveolar lavage (BAL) fluid from patients with allergic asthma have demonstrated active migration of eosinophils into the bronchial lumen after allergen challenge. The mechanisms mediating this eosinophil infiltration and cell activation are largely unexplained. The expression of several cell-surface molecules was measured on eosinophils derived from blood and BAL fluid 4 h after an allergen-induced early asthmatic reaction in order to find indications for a role of these molecules during extravasation to and activation in the bronchial compartment. Nine patients with allergic asthma participated in the study. An eosinophil-specific, high-depolarization signal enabled us to measure expression on eosinophils in a fluorescence activated cell sorter (FACS) analysis without isolation of these cells. Eosinophils recovered from BAL showed a different phenotype than blood eosinophils; upregulation of CR-3, p150/95, CD67, and CD63, and downregulation of L-selectin indicate that the cells are activated in terms of degranulation. Up-regulation of intercellular adhesion molecule-1 (ICAM-1), LFA-3, and human leukocyte antigen II (HLA-II) might enable cell-cell contact between T-lymphocytes and eosinophils, probably leading to immunomodulation and cell activation. The finding that eosinophils in BAL are activated and can interact with T cells is further evidence for the proinflammatory role of these cells in allergic asthma.
713-3 β -Blocker Agents Prevent Oxygen Radical-induced Human Apolipoprotein-B 100 Oxidation
Authors: Claudio Napoli, Giuseppe Ambrosio, Giuseppe Palumbo, Claudia Miele, Paola Chiariello, Annalisa Scognamiglio, Mario Condorelli, Massimo Chiariello
Journal: Journal of the American College of Cardiology (1995)
Pediatric Emergency Medicine: Concepts and Clinical Practice
Authors: Robert Listernick
Journal: JAMA (1993)

The rapid proliferation of textbooks on pediatric emergency medicine highlights the relatively youthful status of this subspecialty. For such a textbook to be helpful in the emergency department, it must be comprehensive, allow for easy retrieval of information, and be particularly adept at presenting differential diagnostic possibilities and management considerations.<i>Pediatric Emergency Medicine: Concepts and Clinical Practice</i>, edited by Barkin, fits the bill on all four counts. Clearly, the editor has expended a great deal of effort to ensure that the text is the most comprehensive put together to date on this topic. The chapters on trauma are particularly good at presenting all the common injuries that the physician might encounter. For example, the chapter on the upper extremity starts with clavicular fractures and then proceeds systematically down the arm to radial and ulnar diaphyseal fractures, with helpful illustrations and clear discussions of each subject. However, the attempt at all-inclusiveness
Palmoplantar keratoderma with an unusual composition of stratum corneum and serum sterol derivatives: a new entity?
Authors: K.E. BARLAG, G. GOERZ, T. RUZICKA, N.Y. SCHURER
Journal: British Journal of Dermatology (1995)

Journal Article Palmoplantar keratoderma with an unusual composition of stratum corneum and serum sterol derivatives: a new entity? Get access K.E. BARLAG, K.E. BARLAG Department of Dermatology, Heinrich‐Heine‐University of Düsseldorf, 40225 Düseldorf, Germany Search for other works by this author on: Oxford Academic Google Scholar G. GOERZ, G. GOERZ Department of Dermatology, Heinrich‐Heine‐University of Düsseldorf, 40225 Düseldorf, Germany Search for other works by this author on: Oxford Academic Google Scholar T. RUZICKA, T. RUZICKA Department of Dermatology, Heinrich‐Heine‐University of Düsseldorf, 40225 Düseldorf, Germany Search for other works by this author on: Oxford Academic Google Scholar N.Y. SCHÜRER N.Y. SCHÜRER Department of Dermatology, Heinrich‐Heine‐University of Düsseldorf, 40225 Düseldorf, Germany Dr N.Y.Schürer. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 4, 1 October 1995, Pages 639–643, https://doi.org/10.1111/j.1365-2133.1995.tb02721.x Published: 01 October 1995 Article history Accepted: 14 November 1994 Published: 01 October 1995
Number of people with diabetes will increase by 40% by 2023, says report
Authors: R. Dobson
Journal: BMJ (2002)

The number of patients diagnosed with diabetes in England and Wales could increase by more than 40% by 2023, a new report says.

The report says that the increasing numbers means that those people at highest risk, such as overweight people, could be targeted for prevention programmes ( Health Statistics Quarterly 2002;14:5-13).

It says: “Body mass index has been identified as a dominant risk factor for diabetes, and the risk of diabetes was reduced among men who took regular exercise. In Finland, type …
DRGs and Hospital Impact: An Organizational Systems Analysis
Authors: Odin W. Anderson
Journal: JAMA (1987)

Although the diagnosis-related group (DRG) method of containing hospital costs has not been in effect long enough to measure results, the author attempts to establish a theoretical and analytic framework to study the impact of the method prospectively. The author is sympathetic to the possibilities of the DRG method to transform the internal operation of the hospital so as to ensure a less costly and more efficiently produced product. The method links financial and clinical data so that the manager and physician can be apprised of what is going on in the hospital, patient by patient, clinical procedure by clinical procedure, and importantly, physician by physician. The author draws on organization systems theory as applied to an institution like the hospital, which is a sociotechnical system, ie, an unusual combination of the interactions of human behavior and the technical equipment and procedures forming a social system. To comprehend the impact
Adolescents Who Attempt Suicide
Authors: Linda K. Snelling
Journal: JAMA (1991)

To the Editor. —  I was both astonished and saddened to find that in her recent editorial, Youth Suicide: The Physician's Role in Suicide Prevention, Blumenthal 1 did not discuss the impact of the repression of emerging awareness of homosexuality on the incidence of suicide among young people. The Institute for the Protection of Lesbian and Gay Youth, an educational and advocacy group for youth in New York City with 1000 or more clients per year, reports that 21% of their clients (both male and female) have attempted suicide before the age of 20 years. The incidence of suicide attempts among gay males is reported to be between 18% and 20%. 2 Clearly, these estimates represent more than an occasional youth.  Blumenthal states that precipitating events for suicide among youth are often humiliating in nature, involving interpersonal problems or an impending disciplinary crisis. Being thrown out of the home, school,
Early assessment of minimal residual disease identifies patients at very high relapse risk in NPM-ALK–positive anaplastic large-cell lymphoma
Authors: Christine Damm-Welk, Lara Mussolin, Martin Zimmermann, Marta Pillon, Wolfram Klapper, Ilske Oschlies, Emanuele S. G. d’Amore, Alfred Reiter, Wilhelm Woessmann, Angelo Rosolen
Journal: Blood (2013)
Autologous Blood Donation-Reply
Authors: Lawrence T. Goodnough
Journal: JAMA (1988)

<h3>In Reply.</h3> —The letter by Dr Kempen concerning the merits of acute normovolemic hemodilution for optimal blood conservation deserves several comments. He is certainly correct in saying that this technique is underutilized by surgeons and anesthesiologists; an American Association of Anesthesiology workshop has been scheduled to address issues related to this (L. Stehling, MD, personal communication, Feb 8, 1988). Methods of autologous procurement and blood transfusion (preoperative autologous donation, acute normovolemic hemodilution, and blood salvage and reinfusion) are complementary; when these are coupled with physician acceptance of postoperative normovolemic anemia, the subsequent use of homologous blood in certain surgical situations such as coronary artery revascularization has been shown to be dramatically reduced.<sup>1</sup> We have analyzed 175 consecutive adult patients undergoing elective orthopedic procedures enrolled in our autologous blood predeposit program to define possible limitations of autologous preoperative donation.<sup>2</sup>As seen in the Table, 145 (83%) were able to
Thyroid Disease 60 Years After Hiroshima and 20 Years After Chernobyl
Authors: John D. Boice
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cineradiography of Esophageal Varices
Authors: D. C. Adler, B. J. Haverback, H. I. Meyers
Journal: JAMA (1964)

Cineradiography of the esophagus and esophagoscopy were performed on 76 patients with clinically suspected esophageal varices. Varices were diagnosed cineradiographically in 67 patients. In comparing the radiological and endoscopic findings, there was an 85% agreement as to the presence or absence of varices. The 15% disagreement occurred almost entirely within the group with very small varices. Considerable disagreement arose in judging the size of the varices. Abnormal dilatation and lack of peristalsis of the esophagus were found in almost two thirds of the patients. There was a direct relationship between the degree of the dynamic change and the size of the varices. Dilatation and lack of peristalsis of the esophagus in a cirrhotic patient should suggest the likelihood of varices, even though the same findings may interfere with the demonstration of varices.
An Unexpected Reaction to Procainamide
Authors: John A. King
Journal: JAMA (1963)

DURING THE DECADE in which procainamide hydrochloride has been used as a cardiac depressant, several types of undesirable side effects have been described. This case report deals with such a reaction and includes some interesting laboratory data obtained during the acute episodes. <h3>Report of a Case</h3> A 78-year-old white, single woman, whose case has been followed since 1921, intermittently has complained of "flutter" of the heart since 1928. It was not until 1952, however, that circumstances permitted documentation of paroxysmal atrial fibrillation. Such arrhythmia was observed during clinical examination and recorded by electrocardiograph. There were no signs of thyrotoxicosis. Digitalization did not prevent subsequent attacks. Quinidine was later added but had to be discontinued because a purpuric skin eruption occurred. Procainamide was then prescribed and was found to control the recurring attacks of "heart flutter," according to the patient. Medications taken regularly by the patient were digoxin, mild sedatives, and
Health in the Middle East
Authors: Wasim Maziak
Journal: BMJ (2006)

Recent studies have shown that the phase of low-frequency local field potentials (LFPs) in sensory cortices carries a significant amount of information about complex naturalistic stimuli, yet the laminar circuit mechanisms and the aspects of stimulus dynamics responsible for generating this phase information remain essentially unknown. Here we investigated these issues by means of an information theoretic analysis of LFPs and current source densities (CSDs) recorded with laminar multi-electrode arrays in the primary auditory area of anesthetized rats during complex acoustic stimulation (music and broadband 1/<i>f</i> stimuli). We found that most LFP phase information originated from discrete “CSD events” consisting of granular–superficial layer dipoles of short duration and large amplitude, which we hypothesize to be triggered by transient thalamocortical activation. These CSD events occurred at rates of 2–4 Hz during both stimulation with complex sounds and silence. During stimulation with complex sounds, these events reliably reset the LFP phases at specific times during the stimulation history. These facts suggest that the informativeness of LFP phase in rat auditory cortex is the result of transient, large-amplitude events, of the “evoked” or “driving” type, reflecting strong depolarization in thalamo-recipient layers of cortex. Finally, the CSD events were characterized by a small number of discrete types of infragranular activation. The extent to which infragranular regions were activated was stimulus dependent. These patterns of infragranular activations may reflect a categorical evaluation of stimulus episodes by the local circuit to determine whether to pass on stimulus information through the output layers.
Reflections on a Whipple
Authors: Carolyn Kanter
Journal: Annals of Internal Medicine (2014)

On Being a Patient18 March 2014Reflections on a WhippleCarolyn Kanter, BACarolyn Kanter, BAFrom New York University School of Medicine, New York, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M13-2451 Audio Reading - “Reflections on a Whipple” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Reflections on a Whipple," by C. Kanter. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Although it is said that physicians make the worst patients, there is compelling evidence that medical students set the bar: They know just enough to be terrified of everything. Med Student Syndrome, the very real fear of acquiring every rare disease that we study, is endemic in medical students. In my first year, a particularly heavy menstrual period was endometriosis, my fibrocystic breasts were rife with cancer, and the occasional stress-induced headache was a fast-growing tumor. It thus came as no surprise to me that, shortly after a close friend was diagnosed with colon cancer, I began to have abdominal ... Author, Article, and Disclosure InformationAffiliations: From New York University School of Medicine, New York, New York.Corresponding Author: Carolyn Kanter, BA, New York University School of Medicine, 56 Saint Mark's Place, 1D, New York, NY 10003; e-mail, Carolyn.[email protected]nyu.edu. PreviousarticleNextarticle Advertisement Audio Reading - “Reflections on a Whipple” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Reflections on a Whipple," by C. Kanter. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 18 March 2014Volume 160, Issue 6Page: 434-435KeywordsBurnsCatheterizationFearNursesStomachSurgeryUrinationVisionVomiting ePublished: 18 March 2014 Issue Published: 18 March 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Surgery for Recurrent Colon Cancer
Authors: Paul H. Sugarbaker
Journal: Annals of Internal Medicine (1999)

Letters2 February 1999Surgery for Recurrent Colon CancerPaul H. Sugarbaker, MDPaul H. Sugarbaker, MDWashington Hospital Center; Washington, DC 20010Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-3-199902020-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with great interest the article describing the results of reoperative surgery for patients with recurrent colon cancer (1). It was gratifying to see that conscientious follow-up combined with aggressive reoperative surgery resulted in disease-free survival of 5 years in 23% of patients who had curative-intent surgery. Most of these patients had hepatic, local, or lung recurrences.Findings were disappointing in patients who had recurrent colon cancer at other sites. A majority of these patients had metastases to abdominal surfaces, ovaries, retroperitoneal nodes, or the abdominal wall. I would suspect intuitively that the route of dissemination ...References1. Goldberg RM, Fleming TR, Tangen CM, Moertel CG, Macdonald JS, Haller DG, et al . Surgery for recurrent colon cancer: strategies for identifying resectable recurrence and success rates after resection. Ann Intern Med. 1998;129:27-35. LinkGoogle Scholar2. Sugarbaker PH, Schellinx ME, Chang D, Koslowe P, von Meyerfeldt M. Peritoneal carcinomatosis from adenocarcinoma of the colon. World J Surg. 1996;20:585-91. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Paul H. Sugarbaker, MDAffiliations: Washington Hospital Center; Washington, DC 20010 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSurgery for Recurrent Colon Cancer: Strategies for Identifying Resectable Recurrence and Success Rates after Resection Richard M. Goldberg , Thomas R. Fleming , Catherine M. Tangen , Charles G. Moertel , John S. Macdonald , Daniel G. Haller , and John A. Laurie Surgery for Recurrent Colon Cancer Charles M. Bagley Jr. Surgery for Recurrent Colon Cancer Richard M. Goldberg , Thomas R. Fleming , and Catherine M. Tangen Metrics 2 February 1999Volume 130, Issue 3Page: 239KeywordsCarcinomatosisChemotherapyColorectal cancerDisease free survivalLiverLiver diseasesLungsLymphOvariesSurgery ePublished: 15 August 2000 Issue Published: 2 February 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A supervised learning framework of statistical shape and probability priors for automatic prostate segmentation in ultrasound images
Authors: Soumya Ghose, Arnau Oliver, Jhimli Mitra, Robert Martí, Xavier Lladó, Jordi Freixenet, Désiré Sidibé, Joan C. Vilanova, Josep Comet, Fabrice Meriaudeau
Journal: Medical Image Analysis (2013)
Letter: practolol, indoramin, and asthma.
Authors: E Paice, E S El Hassan
Journal: BMJ (1975)

Head injuries in skiing have been a cause for concern due to the high incidence of injury particularly in young people. Furthermore, head trauma is the leading cause of death overall in skiing. Encouraging individuals to wear helmets can be problematic, especially since helmets are not compulsory in many resorts, are an additional expense and not seen as a necessity. The aim was (1) To synthesise information regarding head injuries and helmet use in young people. (2) To make a recommendation for the appropriateness of helmets use. Following ethical approval and informed consent, 101 responses were gathered from an electronic survey. This was administered to secondary schools across England which organise ski trips to identify helmet use. Electronic databases were searched for articles dating back 15 years and synthesised with grey literature as a narrative review to inform current concepts on helmet use in young people. The pooled narrative findings from literature suggest helmet use has reduced the number and severity of injuries to the head. The overall consensus is for helmets to be recommended, especially in the young. From 101 secondary schools surveyed, 96% of teachers expect young people to wear helmets whilst skiing. Discussion: The compulsory wearing of helmets in several resorts has helped to increase the awareness and importance of helmet use. A potential impact on not wearing a helmet is the concern that holiday insurance could be invalidated if injured. One British insurer now stipulates for the mandatory wearing of helmets within their policy. Findings show helmet use has been associated with a reduced risk of head injuries and the International Ski Federation recommends that all skiers regardless of ability and age use helmets. Ski helmets should be included within the ski rental package to decrease financial barriers.
Hepatocellular carcinoma in alcoholic liver disease: No evidence for a pathogenetic role of hepatitis B virus infection
Authors: Eike Walter, Hubert E. Blum, Peter Meier, Martin Huonker, Martin Schmid, Klaus-Peter Maier, Wolf-Bernhard Offensperger, Silke Offensperger, Wolfgang Gerok
Journal: Hepatology (1988)

Hepatocellular carcinoma tissues from HBsAg-negative patients with chronic alcoholic liver disease were investigated for the presence of hepatitis B virus DNA. Southern blot analyses of DNA extracted from the hepatocellular carcinomas were negative for hepatitis B virus DNA in all 17 patients examined, at a level of sensitivity of less than 0.01 genome equivalent per cell. Similarly, in liver tissues from another 30 patients with alcoholic cirrhosis without hepatocellular carcinoma, no hepatitis B virus DNA was detectable. We conclude that in our patients there is no molecular evidence for a contribution of hepatitis B virus infection to the development of hepatocellular carcinoma in alcoholic liver disease.
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
Authors: Patrizia Noris, Ginevra Biino, Alessandro Pecci, Elisa Civaschi, Anna Savoia, Marco Seri, Federica Melazzini, Giuseppe Loffredo, Giovanna Russo, Valeria Bozzi, Lucia Dora Notarangelo, Paolo Gresele, Paula G. Heller, Nuria Pujol-Moix, Shinji Kunishima, Marco Cattaneo, James Bussel, Erica De Candia, Claudia Cagioni, Ugo Ramenghi, Serena Barozzi, Fabrizio Fabris, Carlo L. Balduini
Journal: Blood (2014)
Restless Genital Syndrome
Authors: Sanjay Pandey, Neelav Sarma
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal