tbuckley/cabot-search huggingface dataset:
Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up
Authors: Hagop Kantarjian, Jorge Cortes, Dong-Wook Kim, Pedro Dorlhiac-Llacer, Ricardo Pasquini, John DiPersio, Martin C. Müller, Jerald P. Radich, H. Jean Khoury, Nina Khoroshko, M. Brigid Bradley-Garelik, Chao Zhu, Martin S. Tallman
Journal: Blood (2009)
Flow cytometric analysis of vesicular pH in rat hepatocytes after ethanol administration
Authors: K K Kharbanda, D L McVicker, R K Zetterman, R G MacDonald, T M Donohue
Journal: Hepatology (1997)

We examined the effect of ethanol administration on intravesicular pH in intact hepatocytes by applying a flow cytometric technique to detect fluorescein-isothiocyanate-dextran (FITC-dextran) in acidic vesicles. Rats were pair-fed liquid diets containing either ethanol or isocaloric carbohydrate for 1 to 5 weeks. Our study showed that ethanol administration increased the in situ pH of hepatic lysosomes by 0.15 to 0.2 pH units. This pH increase was sufficient to cause a significant reduction in lysosomal protein degradation. Long-term ethanol administration also caused a significant alkalinization of hepatic endosomes, and this increased pH was sustained over the course of vesicular acidification in hepatocytes incubated in vitro . Direct exposure of hepatocytes from rats fed control diet to either 25 mmol/L ethanol or 50 μmol/L colchicine also brought about a rapid alkalinization of acidic vesicles in a manner that resembled that seen in hepatocytes from ethanol-fed rats. These same treatments augmented the vesicular alkalinization already present in cells from ethanol-fed animals. Although ethanol administration had no effect on the content of the hepatic mannose-6-phosphate/IGFII receptor, the results indicate that sustained alkalinization of endosomes could have important functional consequences by impairing M-6-P/IGFII receptor recycling, thereby disrupting the delivery of newly synthesized hydrolases to lysosomes. This decreased complement of hydrolases within lysosomes together with alkalinization of the intralysosomal compartment would result in an overall decrease in lysosomal proteolysis.
Simple, rapid, and automated method for detection of hyperaggregability of platelets using a hematology analyzer
Authors: Mie Shimizu, Masahiro Yamamoto, Hayato Miyachi, Yukito Shinohara, Yasuhiko Ando
Journal: American Journal of Hematology (2003)

Abstract Estimation of hyperaggregability of platelets is important for diagnosis and prevention of vascular events. We have developed and evaluated a simple and rapid method for detection of a hyperaggregable state of platelets by using an Abbott CELL‐DYN® 4000 hematology analyzer. Citrated blood samples were collected from 62 patients with chronic cerebral infarction (CCI), of whom 19 patients were treated with ticlopidine, and from 9 healthy subjects. Platelet clumps were detected in the scatter plots for white blood cell populations with the hematology analyzer. Platelet clumps were positive in 20 of 43 (46.5%) CCI patients who were not treated with anti‐platelet agents but not at all in 9 healthy subjects and in 19 CCI patients treated with ticlopidine. The detection of platelet clumps in citrated blood by the hematology analyzer was proved useful in detecting a platelet hyperaggregability in CCI patients. This method is simple, rapid, and automated and thus should be suitable for routine clinical use for monitoring indications and the efficacy of anti‐platelet drugs. Am. J. Hematol. 72:282–283, 2003. © 2003 Wiley‐Liss, Inc.
Asthma in children: environmental factors
Authors: P Cullinan, A J N Taylor
Journal: BMJ (1994)

Two studies of asthma in children, using identical survey methods and objective assessments separated by a period of 10-15 years, have now been published; each shows an increase in asthmatic symptoms and airway hyper-responsiveness and in seasonal rhinitis.1 (p 1591).2 The increased prevalence of asthma has been matched by, and is probably a manifestation of, an increase in sensitisation among children to inhaled allergens, such as those present in house dust, cat fur, and grass pollen.3

Although genetic factors are important in determining both the propensity to atopic disease and the specificity of the response to protein epitopes, the short period during which the increases in asthma and other allergic diseases have occurred suggests that environmental influences have been mainly responsible. For example, secular trends in the Finnish armed forces show a 20-fold increase in asthma among 18 year old recruits during the past 30 years.4

Further evidence of important environmental influences comes from the recent observation that sensitisation to common aeroallergens is about …
IONIC MEDICATION IN THE TREATMENT OF NEURITIC AND RHEUMATIC PAINS
Authors: W. F. Somerville
Journal: BMJ (1921)

RHEUMATIC PAINS.[MIAzDamsmNL 825 removal of the sac a siingle layer of ilio-tibial band(I was inserted in the way described and the wounid was closed.'lie patient replied to a letter of-mine on Juine 16th. 1921,stating that lie is a miner, and is able to *do fuill woirk w,ithout aLiy troub'e; that lie has never worn a truss; that the scar loes not builge on1 coughing or straining, and(I that he is most Svateful for the result. CASE IILA. M. 13.: doul)le inguinal hernia.Left side operated on March 15tlh, 1917.The hernia waw as large as in the first case.A douible thickness of ilio-titial band, prodluiced by folding the
Imipramine and pregnancy.
Authors: M Sim
Journal: BMJ (1972)

Surely the essential feature is the presence of a significant degree of mitral stenosis -that is to say, enough to raise left atrial pressure under various conditions such as exercise, emotion, pregnancy, or tachycardia from any cause.Operation for removal of clot is not an accepted procedure apart from valvotomy.The statement that valvotomy is indi- cated "provided the valve is suitable for it" is in our experience meaningless because what the surgeon will be able to achieve cannot by any method be predicted pre- operatively.The unreliability of the signs of a so-called pliant valve have been pre- viously stressed.5An excellent valvotomy
Gastroenterology. Volume 1: [esophagus and stomach.]
Authors: Sumner C. Kraft
Journal: JAMA (1963)

This initial volume in the revised edition of Bockus' textbook keeps abreast of the tremendous progress being made in gastroenterology and related phases of internal medicine and surgery during the last two decades. Dr. Bockus, in collaboration with 31 of his present and former colleagues at the University of Pennsylvania, has essentially rewritten the entire text, although the original format has been maintained. This volume deals with the examination of the patient plus physiological, clinical, radiologic, pathologic, and surgical aspects of affections of the esophagus and stomach, including duodenal ulcer. Each chapter is headed by a rather detailed outline and recent and historic references are abundant for most topics. The generous use of photographs, photomicrographs, diagrams, and roentgenograms admirably complements the highly readable text. Despite the somewhat uniform gastroenterological backgrounds of the contributors, there usually is mention of alternate theories of pathogenesis and methods of therapy when appropriate. This book
Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner
Authors: Shan Shao, Xiaoai Zhao, Xiaojin Zhang, Minna Luo, Xiaoxiao Zuo, Shangke Huang, Ying Wang, Shanzhi Gu, Xinhan Zhao
Journal: Molecular Cancer (2015)

The epithelial–mesenchymal transition (EMT) is crucial for the invasion and metastasis of breast cancer. However, how Notch signaling regulates the EMT process and invasion in breast cancer remains largely unknown. The impact of Notch1 silencing by specific shRNAs on the EMT and invasion of human breast cancer MCF-7 and MDA-MB-231 cells as well as xenografts was tested by western blot, real-time polymerase chain reaction (RT-PCR), immunofluorescence, transwell, and immunohistochemistry assays. The effect of Slug silencing or upregulation on the EMT and invasion of breast cancer cells was analyzed, and the effect of Notch1 signaling on Slug expression was determined by the luciferase reporter assay. The Notch1 intracellular domain (N1ICD) and Jagged1 were expressed in breast cancer cells. Notch1 silencing reversed the spontaneous EMT process and inhibited the migration and invasion of breast cancer cells and the growth of xenograft breast cancers. The expression of N1ICD was upregulated significantly by Jagged1-mediated Notch signaling activation. Moreover, Jagged1-mediated Notch signaling promoted the EMT process, migration, and invasion of breast cancer cells, which were abrogated by Notch silencing. Furthermore, the N1ICD positively regulated the Slug expression by inducing Slug promoter activation. Importantly, the knockdown of Slug weakened the invasion ability of breast cancer cells and reversed the Jagged1-induced EMT process with significantly decreased expression of vimentin and increased expression of E-cadherin. In addition, Slug overexpression restored the Notch1 knockdown-suppressed EMT process. Our novel data indicate that Notch signaling positively regulates the EMT, invasion, and growth of breast cancer cells by inducing Slug expression. The Notch1–Slug signaling axis may represent a potential therapeutic target for breast cancer therapy.
Hajj pilgrims’ knowledge about Middle East respiratory syndrome coronavirus, August to September 2013
Authors: P Gautret, S Benkouiten, I Salaheddine, K Belhouchat, T Drali, P Parola, P Brouqui
Journal: Eurosurveillance (2013)

In preparation for Hajj 2013, 360 French pilgrims were interviewed regarding their knowledge about Middle East respiratory syndrome (MERS). Respondents were aged 20–85 years, male-female ratio was 1.05:1;64.7% were aware of the MERS situation in Saudi Arabia; 35.3% knew about the Saudi Ministry of Health recommendations for at-risk pilgrims to postpone participation in the 2013 Hajj. None of 179 at-risk individuals(49.9%) decided to cancel their Hajj participation even after advice during consultation.
Determination of Human Ventricular Repolarization by Noncontact Mapping
Authors: Arthur M. Yue, John R. Paisey, Steve Robinson, Tim R. Betts, Paul R. Roberts, John M. Morgan
Journal: Circulation (2004)

Background— Noncontact mapping (NCM) has not been validated as a clinical technique to measure ventricular repolarization. We used NCM to determine repolarization characteristics by analysis of reconstructed unipolar electrograms (UEs) at the same sites as monophasic action potential (MAP) recordings in the human ventricle. Methods and Results— MAPs were recorded from a total of 355 beats at 46 sites in the left or right ventricle of 9 patients undergoing ablation of ventricular tachycardia guided by NCM (EnSite system). Measurements were made during sinus rhythm, constant right ventricular pacing, and ventricular extrastimuli during restitution-curve construction. The EnGuide locator signal was used to document MAP catheter locations on the endocardial geometry. UE-determined activation-recovery interval (ARI) measured at the maximum derivative of the T wave (Wyatt method) and the minimum derivative of the positive T wave (alternative method) was correlated with MAP measured at 90% repolarization (MAP90%) at the same sites. ARI correlated with MAP90% during steady state by the Wyatt method ( r =0.83, P &lt;0.001) and the alternative method ( r =0.94, P &lt;0.001). Restitution curves constructed from MAP and UE data exhibited the same characteristics, with a mean correlation coefficient of 0.95 (range, 0.90 to 0.99, P &lt;0.001). The error between ARI and MAP90% was greater over a shorter diastolic coupling interval but was not influenced by distance of the sampling site from the multielectrode array. Conclusions— NCM accurately determines steady-state and dynamic endocardial repolarization in humans. Global, high-density, NCM data could be used to characterize abnormalities of human ventricular repolarization.
POTENT CARDIOPROTECTIVE EFFECTS OF LOW DOSE INSULIN-LIKE GROWTH FACTOR-1 (LD-IGF-1) TREATMENT POST MYOCARDIAL INFARCTION ARE MEDIATED THROUGH PHOSPHORYLATION OF THE IGF-1 RECEPTOR, GSK-3BETA INHIBITION AND SURVIVAL KINASE UPREGULATION
Authors: John F. O'Sullivan, Anne-Laure Leblond, Pat Metharom, Arun HS Kumar, Geraldine Kelly, Eva Hristova, Brian Hynes, Rosemary O'Connor, Noel M. Caplice
Journal: Journal of the American College of Cardiology (2011)
Brain damaged baby dies after court rules that his ventilator may be turned off
Authors: C. Dyer
Journal: BMJ (2009)

A chronically ill 9 month old boy at the centre of a battle between his parents and doctors died last week after judges ruled that he should be taken off the ventilator keeping him alive.

The baby, who was known only as OT to protect his identity, died after two judges in the Court of Appeal in London last week upheld a ruling by a High Court judge that it was in his best interests to be allowed …
Plasma Protein Acute-Phase Response in Unstable Angina Is Not Induced by Ischemic Injury
Authors: Giovanna Liuzzo, Luigi M. Biasucci, Antonio G. Rebuzzi, J. Ruth Gallimore, Giuseppina Caligiuri, Gaetano A. Lanza, Gaetano Quaranta, Claudia Monaco, Mark B. Pepys, Attilio Maseri
Journal: Circulation (1996)

Background Elevated levels of C-reactive protein (CRP) are associated with an unfavorable clinical outcome in patients with unstable angina. To determine whether ischemia-reperfusion injury causes this acute-phase response, we studied the temporal relation between plasma levels of CRP and ischemic episodes in 48 patients with unstable angina and 20 control patients with active variant angina, in which severe myocardial ischemia is caused by occlusive coronary artery spasm. Methods and Results Blood samples were taken on admission and subsequently at 24, 48, 72, and 96 hours. All patients underwent Holter monitoring for the first 24 hours and remained in the coronary care unit under ECG monitoring until completion of the study. On admission, CRP was significantly higher in unstable angina than in variant angina patients ( P &lt;.001). In unstable angina, 70 ischemic episodes (1.5±2 per patient) and in variant angina 192 ischemic episodes (9.6±10.7 per patient) were observed during Holter monitoring ( P &lt;.001), for a total ischemic burden of 14.8±30.2 and 44.4±57.2 minutes per patient, respectively ( P &lt;.001). The plasma concentration of CRP did not increase in either group during the 96 hours of study, even in patients who had episodes of ischemia lasting &gt;10 minutes. Conclusions The normal levels of CRP in variant angina, despite a significantly larger number of ischemic episodes and greater total ischemic burden, and the failure of CRP values to increase in unstable angina indicate that transient myocardial ischemia, within the range of duration observed, does not itself stimulate an appreciable acute-phase response.
The mysterious "urethral syndrome"
Authors: F. Dobbs, D. Fleming
Journal: BMJ (1991)

Bleeding peptic ulcers SIR,-Professor Stephen Bown is correct to remark on the recent advances in endoscopic treatment of bleeding peptic ulcers.With the emerging evidence of the efficacy of endoscopic techniques, and with an aging population, who tolerate laparotomv badly, these techniques should be more widely available.Professor Bown discusses the evidence of their efficacy in a traditional narrative manner, and I am confident that his conclusions are correct.He has not, however, explored the results of three relevant meta-analyses.24Two of these studies were reviewed at a workshop on meta-analysis in gastrointestinal haemorrhage held in Newcastle, New South Wales, in September last year.'This was a satellite meeting of the World Congress of Gastroenterology.The table summarises the results presented at the workshop.Several conclusions can be drawn.Firstly, evidence of benefit seems to be greatest in the case of laser treatments, with both meta-
517 POST-LIVER TRANSPLANTATION (LT) OUTCOME IN HIV/HCV CO-INFECTED PATIENTS. COMPARISON WITH MONOINFECTED PATIENTS WITH HCV-CIRRHOSIS
Authors: V. Aguilera, C. Vinaixa, A. Rubin, B. Castelló, M. Blanes, F. San Juan, R. López-Andujar, M. Berenguer, M. Prieto
Journal: Journal of Hepatology (2011)
Some Recent Developments in Child-Analysis
Authors: Anna Freud
Journal: Psychotherapy and Psychosomatics (1965)

Research Articles| February 11 2010 Some Recent Developments in Child-Analysis Subject Area: Psychiatry and Psychology Anna Freud Anna Freud London Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1965) 13 (1-3): 36–46. https://doi.org/10.1159/000285754 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Anna Freud; Some Recent Developments in Child-Analysis. Psychother Psychosom 31 December 1965; 13 (1-3): 36–46. https://doi.org/10.1159/000285754 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1965Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Adjuvant Therapy in Stage I and Stage II Epithelial Ovarian Cancer
Authors: Robert C. Young, Leslie A. Walton, Susan S. Ellenberg, Howard D. Homesley, George D. Wilbanks, David G. Decker, Alexander Miller, Robert Park, Francis Major
Journal: New England Journal of Medicine (1990)

About a third of patients with ovarian cancer present with localized disease; despite surgical resection, up to half the tumors recur. Since it has not been established whether adjuvant treatment can benefit such patients, we conducted two prospective, randomized national cooperative trials of adjuvant therapy in patients with localized ovarian carcinoma (International Federation of Gynecology and Obstetrics Stages Ia to IIc). All patients underwent surgical resection plus comprehensive staging and, 18 months later, surgical re-exploration. In the first trial, 81 patients with well-differentiated or moderately well differentiated cancers confined to the ovaries (Stages Iai and Ibi) were assigned to receive either no chemotherapy or melphalan (0.2 mg per kilogram of body weight per day for five days, repeated every four to six weeks for up to 12 cycles). After a median follow-up of more than six years, there were no significant differences between the patients given no chemotherapy and those treated with melphalan with respect to either five-year disease-free survival (91 vs. 98 percent; P = 0.41) or overall survival (94 vs. 98 percent; P = 0.43). In the second trial, 141 patients with poorly differentiated Stage I tumors or with cancer outside the ovaries but limited to the pelvis (Stage II) were randomly assigned to treatment with either melphalan (in the same regimen as above) or a single intraperitoneal dose of 32P (15 mCi) at the time of surgery. In this trial (median follow-up, greater than 6 years) the outcomes for the two treatment groups were similar with respect to five-year disease-free survival (80 percent in both groups) and overall survival (81 percent with melphalan vs. 78 percent with 32P; P = 0.48). We conclude that in patients with localized ovarian cancer, comprehensive staging at the time of surgical resection can serve to identify those patients (as defined by the first trial) who can be followed without adjuvant chemotherapy. The remaining patients with localized ovarian cancer should receive adjuvant therapy, and with adjuvant melphalan or intraperitoneal 32P should have a five-year disease-free survival of about 80 percent.
Pathophysiology of Dermatologic Diseases
Authors: Keyoumars Soltani
Journal: JAMA (1985)

This brief text covers the biologic and pathophysiological bases of a selected group of skin disorders. Primarily intended for students and physicians in training, the book evolved from a decade-old course on the pathophysiology of the skin given at Harvard Medical School. The book is not intended to be a treatise. The editors and other authors nevertheless have achieved their goal of providing the reader with an updated summary of the relevant subjects. It is written in a clear and concise style and edited well to give uniformity to the various chapters authored by 30 investigators. It covers a broad spectrum of subjects, including the normal structure and development of skin in various disease states, and concludes with a brief chapter on important psychiatric considerations in these disorders. The index is relatively comprehensive, and a random survey of it did not reveal any errors. In summary, I recommend this book
Out of hours workload in general practice: deprivation or expectation?
Authors: A Orr, D MacNeill, J Griffith, A Begg
Journal: BMJ (1990)

had genital herpes and are thus at risk of a primary infection in pregnancy.6What useful advice or reassurance can be given on the basis of knowing a woman's antibody state?Doctors should not refuse to test women who are concerned about particular infections.Never- theless, the implications of any test, including difficulties in interpretation, must be discussed beforehand.But screening is not an appropriate description of tests undertaken in these circum- stances -screening is a service offered routinely to all women in which the advantages of testing are not outweighed by the disadvantages.It is unreasonable to offer screening tests for conditions simply because the tests are available, and it is extremely unwise to pursue the piecemeal intro- duction of screening tests before proper evaluation using recognised criteria.
Occurrence of Tetany in Litters of New Zealand White Rabbits Associated with Spontaneous Verterbral Fractures and Limb Malformations
Authors: B. Ingham, D. W. Brentnall, D. H. M. Woollam, J. W. Millen
Journal: BMJ (1965)

Radiograph of youngNew Zealand white rabbit.Left above: enlarged view of thoracic spine showing fracture-dislocation of vertebrae.Left below: young New Zealand white rabbit