tbuckley/cabot-search huggingface dataset:
TRAUMATIC ARTERIO-VENOUS ANEURYSMS OF THE SUBCLAVIAN VESSELS, WITH AN ANALYTICAL STUDY OF FIFTEEN REPORTED CASES, INCLUDING ONE OPERATED UPON.
Authors: RUDOLPH MATAS
Journal: JAMA (1902)

<h3>HISTORY SUBSEQUENT TO OPERATION.</h3> The subsequent career of this patient after the operation was marked by many incidents which delayed his convalescence and caused us much anxiety as to the ultimate fate of his arm, but never gave us serious apprehensions as to his ultimate recovery. Some idea may be obtained of the tediousness of his convalescence by noting that he was admitted to the hospital on September 8 (fifth day after the injury), was operated on September 13 (ninth day), and was discharged Nov. 12, 1900 (sixty-first day), and even then his arm had not healed, and he was not entirely discharged by Dr. Power at his home until April 19, 1901 (158 days after leaving the sanitarium), when he discarded his last dressings. He was, therefore, under treatment a little over seven months from the date of the operation. It is just to state that this delay in
Hand-Assisted Laparoscopy
Authors: Rebecca Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Care Professionals and Qualifications
Authors: Janet M. Torpy, Edward H. Livingston
Journal: JAMA (2012)

Health Care Professionals and QualificationsT here are many types of health care professionals.Traditional roles and responsibilities held by physicians and nurses have changed, along with the expansion of technology and the demand for health care services.The education, certifications, and licensures for types of health care practitioners differ, as does their scope of practice (what they are allowed by law to do for patients).The December 5, 2012, issue of JAMA is a theme issue on medical education.
Successful Treatment of Ciguatera Fish Poisoning With Intravenous Mannitol
Authors: Neal A. Palafox
Journal: JAMA (1988)

Twenty-four patients with acute ciguatera fish poisoning were treated with intravenous mannitol, and each patient's condition improved dramatically. All exhibited marked lessening of neurologic and muscular dysfunction within minutes of the administration of mannitol. Gastrointestinal symptoms disappeared more slowly. Two patients in coma and one in shock responded within minutes, with full recovery after infusion. Although these observations were empiric and uncontrolled and the mechanism of action of mannitol in this disease is unclear, mannitol should be considered for initial use in patients with significant illness and morbidity from ciguatera fish poisoning.
NOVEL ECHOCARDIOGRAPHIC ASSESSMENT OF RIGHT VENTRICULAR FUNCTION IN PRETERM INFANTS: FEASIBILITY AND REPRODUCIBILITY OF RIGHT VENTRICULAR STRAIN MEASUREMENTS BY SPECKLE-TRACKING ECHOCARDIOGRAPHY
Authors: Philip Thaler Levy, Mark Holland, Timothy J. Sekarski, Aaron Hamvas, Gautam K. Singh
Journal: Journal of the American College of Cardiology (2013)
A systematic review: Effect of angiotensin converting enzyme inhibition on left ventricular volumes and ejection fraction in patients with a myocardial infarction and in patients with left ventricular dysfunction
Authors: Jawdat Abdulla, Simona Barlera, Roberto Latini, Lars Kjoller‐Hansen, Peter Sogaard, Erik Christensen, Lars Kober, Christian Torp‐Pedersen
Journal: European Journal of Heart Failure (2006)
Tregs and allergic disease
Authors: Douglas S. Robinson, Mark Larché, Stephen R. Durham
Journal: Journal of Clinical Investigation (2004)

Allergic diseases such as asthma, rhinitis, and eczema are increasing in prevalence and affect up to 15% of populations in Westernized countries. The description of Tregs as T cells that prevent development of autoimmune disease led to considerable interest in whether these Tregs were also normally involved in prevention of sensitization to allergens and whether it might be possible to manipulate Tregs for the therapy of allergic disease. Current data suggest that Th2 responses to allergens are normally suppressed by both CD4+CD25+ Tregs and IL-10 Tregs. Furthermore, suppression by these subsets is decreased in allergic individuals. In animal models, Tregs could be induced by high- or low-dose inhaled antigen, and prior induction of such Tregs prevented subsequent development of allergen sensitization and airway inflammation in inhaled challenge models. For many years, allergen-injection immunotherapy has been used for the therapy of allergic disease, and this treatment may induce IL-10 Tregs, leading to both suppression of Th2 responses and a switch from IgE to IgG4 antibody production. Improvements in allergen immunotherapy, such as peptide therapy, and greater understanding of the biology of Tregs hold great promise for the treatment and prevention of allergic disease.
Cyclosporin A for treatment of severe lichen planus
Authors: P.D. Pigatto, G. Chiappino, A. Bigardi, N. Mozzanica, A.F. Finzi
Journal: British Journal of Dermatology (1990)

Journal Article Cyclosporin A for treatment of severe lichen planus Get access P.D. Pigatto, P.D. Pigatto Second Department of Dermatology, University of Milan, Via Pace 9, 1‐20122 Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar G. Chiappino, G. Chiappino Second Department of Dermatology, University of Milan, Via Pace 9, 1‐20122 Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar A. Bigardi, A. Bigardi Second Department of Dermatology, University of Milan, Via Pace 9, 1‐20122 Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar N. Mozzanica, N. Mozzanica Second Department of Dermatology, University of Milan, Via Pace 9, 1‐20122 Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar A.F. Finzi A.F. Finzi Second Department of Dermatology, University of Milan, Via Pace 9, 1‐20122 Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 122, Issue 1, 1 January 1990, Pages 121–123, https://doi.org/10.1111/j.1365-2133.1990.tb08255.x Published: 01 January 1990
Serum Electrolyte Changes in Near-Drowning Victims
Authors: Jerome H. Modell
Journal: JAMA (1985)

In the late 1940s, Henry Swann and his colleagues<sup>1,2</sup>performed classic studies on drowning in canines. In these studies, the authors found that, under conditions of total immersion, blood volume and serum electrolyte changes occurred, which could result in death. Reports on human victims of freshwater and seawater drowning and near-drowning most frequently have noted serum electrolyte concentrations as near normal, and those that were abnormal, as rarely life-threatening.<sup>3-6</sup>These observations led to extensive studies of both animals<sup>7,8</sup>and humans<sup>9</sup>that concluded that the most pressing consequences of near-drowning were changes in respiratory function, preponderantly hypoxia and metabolic acidosis. These studies also suggested that human near-drowning victims rarely aspirate enough water to cause life-threatening changes in serum electrolyte concentrations. Furthermore, severe abnormalities in serum electrolyte concentrations could be found in only approximately 15% of persons who had died in the water and were not resuscitated.<sup>10</sup>
Prospective Study of Type 1 and Type 2 Diabetes and Risk of Stroke Subtypes: the Nurses’ Health Study
Authors: Antonino Tuttolomondo, Antonio Pinto, Domenico Di Raimondo, Giuseppe Licata
Journal: Diabetes Care (2007)

We read the article by Janghorbani et al. (1) and have some observations for the authors. First, why did the authors classify stroke subtypes by Perth criteria (2), when TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification (3) would have been, in our opinion, more suitable? Indeed, this classification, evaluating pathophysiological, instrumental, and anatomical findings following an algorithmic procedure, offers …
Complete Resolution of Massive Pulmonary Thromboembolism
Authors: R. D. Sautter, F. W. Fletcher, D. A. Emanuel, B. R. Lawton, T. G. Olsen
Journal: JAMA (1964)

FOR some time there has been speculation concerning the fate of obstructing material in the pulmonary artery in patients who have sustained massive, nonfatal thromboembolism. Pulmonary embolectomy has been considered<sup>1</sup>in such patients to conserve pulmonary function even though the patient's life is not immediately threatened. In the past three years at the Marshfield Clinic, Marshfield, Wis, eight patients with massive pulmonary thromboembolism have been treated. Pulmonary embolectomy was performed or attempted in six of these patients; two patients survived.<sup>2</sup> The case reports presented here are of the two patients who sustained massive pulmonary embolism, but whose clinical condition was such that pulmonary embolectomy was not indicated. Pulmonary arteriography confirmed the diagnosis in each case. Each patient was subsequently restudied, one at 25 days and the other at 128 days. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 29-year-old male was admitted to the hospital on Sept 18, 1963, complaining
Treatment of pachyonychia congenita with plantar injections of botulinum toxin
Authors: C. Swartling, A. Vahlquist
Journal: British Journal of Dermatology (2006)

Journal Article Treatment of pachyonychia congenita with plantar injections of botulinum toxin Get access C. Swartling, C. Swartling Department of Dermatology, University Hospital, SE‐751 85 Uppsala, Sweden Carl Swartling. E‐mail: carl.swartling@akademiska.se Search for other works by this author on: Oxford Academic Google Scholar A. Vahlquist A. Vahlquist Department of Dermatology, University Hospital, SE‐751 85 Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 154, Issue 4, 1 April 2006, Pages 763–765, https://doi.org/10.1111/j.1365-2133.2005.07115.x Published: 01 April 2006 Article history Accepted: 06 September 2005 Published: 01 April 2006
GENDER PERSPECTIVES ON RISK FOR MYOCARDIAL INFARCTION AND REVASCULARIZATION IN PATIENTS WITHOUT SIGNIFICANT CORONARY ARTERY DISEASE: A SCAAR REGISTRY STUDY
Authors: Nina C. Johnston, Birgitta Jönelid, Tanja Kero, Christina Christersson, Henrik Renlund, Karin Schenck-Gustavsson, Bo Lagerqvist
Journal: Journal of the American College of Cardiology (2014)
Reiter's disease in three boys.
Authors: J M Iveson, B S Nanda, J A Hancock, P J Pownall, V Wright
Journal: Annals of the Rheumatic Diseases (1975)

Three cases of Reiter's disease occurring in boys under the age of 16 are reported. One of these presented with a Salmonella enteritidis diarrhoea. This conforms to the 'dysenteric' form of Reiter's disease usually seen in Europe and rarely reported in England. Another presented with a monarticular arthritis of the knee, and the third has developed a chronic relapsing erosive arthritis as a result of sexually acquired Reiter's disease--an occurrence not previously reported in this age group. We draw attention to the frequency of diarrhoea in these children and the sex incidence of 1 female to 4--5 males, which agrees more with Reiter's disease of dysenteric origin than that acquired venereally.
GPs demand a major review of their contracts and pay
Authors: L. Beecham
Journal: BMJ (1997)

British GPs will ask the next government to set up a major review of their contracts and pay, which should take into account the problems of staffing, recruitment, and workload.

The call came at the end of last week's debate in the BMA's General Medical Services Committee on the 1997 report of the review body on doctors' pay. Although the committee received the report (15 February, p 462), it resolved that the award would do nothing to solve the recruitment and workload crisis in general practice and it …
[278] ASSOCIATION OF CYP1B1 GERMLINE MUTATIONS WITH HNF1a MUTATED HEPATOCELLULAR ADENOMA
Authors: E. Jeannot, K. Poussin, L. Chiche, Y. Bacq, N. Sturm, J.Y. Scoazec, C. Buffet, J. Tran Van Nhieu, C. Bellanne-Chantelot, C. de Toma, P. Laurent-Puig, P. Bioulac-Sage, J. Zucman-Rossi
Journal: Journal of Hepatology (2007)
ACHONDROPLASIA: WITH NOTES OF CASES
Authors: G. Rankin, E. C. Mackay, J. R. Lunn, J. Cranke
Journal: BMJ (1907)

tAIMDICAL JOUaRALthis cbintry' is concerned, 'thb 'conclusion -to which -my- prMtice.in. a large bottl-makiidg.districthad pr'eviouslY inblin'icme-that though; as in other trades,'there are nhleni engaged in the bottle'trade who; undobttedly.do -,fer from cataract,.and who come under treatment for 4> there is not sufficient evidence to show that they are I able to the affection to such an extent as has been ,asserted.REFERENCES.
REACTIVE ARTHRITIS AFTER CAMPYLOBACTER JEJUNI ENTERITIS IN PATIENTS WITH HLA-B27
Authors: T.U. Kosunen, O. Kauranen, J. Martio, T. Pitkänen, A. Pönkä, L. Hortling, S. Aittoniemi, O. Mutru, O. Penttilä, Saija Koskimies
Journal: The Lancet (1980)
Life, your career, and the pursuit of happiness...
Authors: C. Gray
Journal: BMJ (1997)

Can it really be true that the happiest people are retired? Carl Gray tackles the big issue -being happy at work 

Doctors can be a miserable lot at times, as shown by the high prevalence of stress in doctors and the demand for the BMA's counselling service in its early months. Discordance between successful work, public perceptions, and personal wellbeing is common and the profession has many such cases. We are also credited with low morale, a high divorce rate, and high risks of alcohol and substance abuse.

Pitfalls are to be expected in medical careers: exposure to human suffering and loss, boredom, and some disappointments in exams, jobs, research, or publications are common to us all. Students and young doctors have always had their idealism brutalised by early experience of life and death situations and the sight of their seniors. Of course, problems - of the problem page kind - are inevitable, and into each life a little rain must fall. The traditional heaven - sitting on a cloud, playing the harp, and eating ambrosia - does seem a little dull, even if you like rice pudding. Problems are necessary challenges, and their solution gives satisfaction. People problems can be the worst, but they can be tackled; even long term feuds have their resolution.

But the prevailing medical Zeitgeist is a weary cynicism, which transcends factors as simple as bad jobs and the effects of health service changes. We must look harder at ourselves. What is the nature of our entrenched unhappiness? Can we be happier in our professional lives? How do the jolly ones do it?

Look at the most fulfilled and happy people of your acquaintance. Prosperous, enjoying active lives, and in touch with a rich social network: they are mostly retired! Excellent examples can be found …
Countries have a long way to go in ensuring that health care is patient centred
Authors: Bob Roehr
Journal: BMJ (2006)

<h3>Abstract</h3> Vascular smooth muscle cells (VSMCs) are the predominant cell type in the medial layer of the aortic wall and normally exist in a quiescent, contractile phenotype where actomyosin-derived contractile forces maintain vascular tone. However, VSMCs are not terminally differentiated and can dedifferentiate into a proliferative, synthetic phenotype. Actomyosin force generation is essential for the function of both phenotypes. Whilst much is already known about the mechanisms of VSMC actomyosin force generation, existing assays are either low throughput and time consuming, or qualitative and inconsistent. In this study, we use polyacrylamide hydrogels, tuned to mimic the physiological stiffness of the aortic wall, in a VSMC contractility assay. Isolated VSMC area decreases following stimulation with the contractile agonists angiotensin II or carbachol. Importantly, the angiotensin II induced reduction in cell area correlated with increased traction stress generation. Inhibition of actomyosin activity using blebbistatin or Y-27632 prevented angiotensin II mediated changes in VSMC morphology, suggesting that changes in VSMC morphology and actomyosin activity are core components of the contractile response. Furthermore, we show that microtubule stability is an essential regulator of isolated VSMC contractility. Treatment with either colchicine or paclitaxel uncoupled the morphological and/or traction stress responses of angiotensin II stimulated VSMCs. Our findings support the tensegrity model and we demonstrate that microtubules act to balance the actomyosin-derived traction stress generation and regulate the morphological responses of VSMCs.
Changes in Health Care Expenditure Associated with Gaining or Losing Health Insurance
Authors: Lisa Ward, Peter Franks
Journal: Annals of Internal Medicine (2007)

Background: Cross-sectional data suggest that changes in health insurance status are associated with expenditures. No national longitudinal analysis has examined this relationship. Objective: To evaluate the association between changes in health insurance status and expenditures. Design: Cohort analyses using the 2000 to 2003 Medical Expenditure Panel Surveys. Setting: U.S. civilian noninstitutionalized population. Participants: Three 2-year cohorts that included 20 848 adults age 21 to 64 years who were stratified by insurance type (private, public, military, or none): 17 130 participants were insured in both years, 342 participants were insured in year 1 and were uninsured in year 2, 385 participants were uninsured in year 1 and were insured in year 2, and 2991 participants were uninsured in both years. Persons who were insured for longer than 2 months but less than 10 months or who switched insurance type were excluded (n = 4039). Measurements: Annual health care expenditures (any or none; amount, contingent on any expenditure; and the difference between year 1 and year 2). Results: Adjusted expenditure probabilities were similar among all participant groups while insured and were higher than those for all participant groups while uninsured: 92.1% (95% CI, 91.4% to 92.7%) in year 1 and 91.8% (CI, 90.9% to 92.5%) in year 2 for persons insured in both years, 74.2% (CI, 71.7% to 76.5%) in year 1 and 74.8% (CI, 72.1% to 77.4%) in year 2 for persons uninsured in both years, and 90.7% (CI, 87.1% to 93.4%) for persons insured in year 1 and 74.6% (CI, 69.4% to 79.2%) for persons uninsured in year 2. The pattern was also consistent for the group that was uninsured in year 1 but insured in year 2. Adjusted annual expenditures among all participant groups with insurance were similar; expenditures among participant groups without insurance were similar but were lower than those among participants with insurance. Consistent differences in expenditures between year 1 and year 2 were observed for all groups. Limitation: Few participants changed insurance status. Conclusion: Changing insurance status is associated with changes in expenditures to levels that are similar to those for persons who are continuously insured or uninsured.
EYE-STRAIN A CAUSE OF EXOPHTHALMIC GOITER
Authors: GEORGE M. GOULD
Journal: JAMA (1910)

ment has been to place around the mask a rubber cover¬ ing which confines the vapor and assists in making the anesthetic more manageable.If one ounce of the oil of bergamot or terpineol is placed with 3 ounces of water in tbe hot-water bottle, the odor of ether or chloroform will be so disguised tbat the patient will be unable to distinguish when (he anesthetic is turned on, and consequently no resistance or asphyxiai symptoms present themselves in going under the anesthetic.Then again, it is much pleasant«* for the surgeon, nurses and others in the room to smell the oil of bergamot or terpineol than to be constantly inhaling the odors of ether and chloroform.At any time the anesthetist can give either chloroform or ether, or any combination of the two.by simply turn¬ ing the single stop-cock, the change being made in less than a fraction of a second, all of tin-vapor passingthrough the third bottle, usually filled with hot water, and terpineol or a hot neutral oil.Unquestionably, a smaller amount of anesthetic is used with this appar¬ atus, or with some similar apparatus, than wilh any qther method now known.It lias been used constantly in some of our largest hospitals since 1905; with increas¬ ingly gratifying results in the following particulars:
Fuseli's Nightmare
Authors: J. Worth Estes
Journal: JAMA (1969)

<h3>To the Editor:—</h3> My own subsequent researches into the interpretation of the painting lead me to different conclusions. First, although I admit I find few who will readily agree with me, the victim of the nightmare lies not merely on a couch, but on what appears to be at least suggestive of a cadaver, showing fairly typical postmortem lividity. This "cadaver's" head and upper limb girdle are not shown, but his left leg and torso are clear, to me at least, inThe Journal'sreproduction. This observation led me to believe that Fuseli had, after all, painted a horror story in the same sense that many of his other paintings are Gothic tales, both those with and without titles or obvious symbolism. I was not convinced that one could ascribe any attempt at descriptive psychopathology to the painting. In an article about the painting, Dr. H. W. Janson of the
Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFkappa B in tumour necrosis factor production
Authors: B. M J Foxwell
Journal: Annals of the Rheumatic Diseases (2000)

The success of anti-tumour necrosis factor (TNF) treatment, either using antibodies or soluble receptors, has defined TNF as a major factor of the inflammatory response in rheumatoid arthritis (RA). As a result of this success, much attention has been devoted to understanding the molecular mechanisms by which TNF expression and activity is elicited and controlled. By understanding these pathways, it is hoped that key elements of the molecular pathology associated with RA will be uncovered and, as a result, new targets for therapeutic intervention will be identified. However, studying the cell and molecular biology of model systems for RA, such as primary human macrophages, or tissue from rheumatoid joints may present technical problems. In an attempt to overcome this, we have investigated the use of adenovirus as a means of delivering transgenes by which different intracellular pathways can be modulated and examined. Our data show that adenovirus can be successfully used to efficiently deliver transgenes to primary human macrophages and RA joint tissue. Using a virus encoding IκBα, the natural inhibitor of NFκB, we show that the requirement for the transcription factor is not universal, but is dependent on the nature of the stimulus. Furthermore, while NFκB is of importance for the expression of TNF and other pro-inflammatory cytokines (for example, interleukin 6) and the destructive matrix metalloproteinases, this factor is not required for the expression of anti-inflammatory cytokines interleukin 10 and interleukin 1 receptor antagonist.