tbuckley/cabot-search huggingface dataset:
The unique combination of dermatological and ocular phenotypes in Alström syndrome: severe presentation, early onset and two novel ALMS1 mutations
Authors: M. Kocova, E. Sukarova-Angelovska, R. Kacarska, P. Maffei, G. Milan, J.D. Marshall
Journal: British Journal of Dermatology (2010)

Journal Article The unique combination of dermatological and ocular phenotypes in Alström syndrome: severe presentation, early onset and two novel ALMS1 mutations Get access M. Kocova, M. Kocova University Pediatric Clinic, Skopje, Republic of Macedonia Search for other works by this author on: Oxford Academic Google Scholar E. Sukarova‐Angelovska, E. Sukarova‐Angelovska University Pediatric Clinic, Skopje, Republic of Macedonia Search for other works by this author on: Oxford Academic Google Scholar R. Kacarska, R. Kacarska University Pediatric Clinic, Skopje, Republic of Macedonia Search for other works by this author on: Oxford Academic Google Scholar P. Maffei, P. Maffei Department of Medical and Surgical Sciences, Endocrine‐Metabolic Laboratory, University of Padua, Padua, Italy Search for other works by this author on: Oxford Academic Google Scholar G. Milan, G. Milan Department of Medical and Surgical Sciences, Endocrine‐Metabolic Laboratory, University of Padua, Padua, Italy Search for other works by this author on: Oxford Academic Google Scholar J.D. Marshall J.D. Marshall The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, U.S.A. 04609 Jan D. Marshall. E‐mail: jan.marshall@jax.org Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 164, Issue 4, 1 April 2011, Pages 878–880, https://doi.org/10.1111/j.1365-2133.2010.10157.x Published: 01 April 2011
Abstract 1106: Targeting both non-coding and coding sequences with small RNA efficiently knocks down DNA repair genes and radiosensitizes human tumor cells
Authors: Zhiming Zheng, Ya Wang, Xiangming Zhang
Journal: Cancer Research (2012)

Abstract During radiotherapy, human tumor cell death is mainly caused by ionizing radiation (IR)-induced DNA double strand breaks (DSBs). In general, human cells use two pathways: homologous recombination repair (HRR) and non-homologous end-joining (NHEJ), to repair DNA DSBs. However, in many cases, human tumors are resistant to IR due to the abnormal up-regulation of DNA DSB repair genes. Previously it was reported that using a siRNA approach could knock down the DNA DSB repair genes and sensitized the tumor cells to IR, however, the levels of knock down using a siRNA approach alone is limited. Here, we developed a novel combined approach using an artificial microRNA (amiR) to target the 3′-untranlated region (UTR) of the DNA DSB repair gene, XRCC2 (a HRR factor) or XRCC4 (a NHEJ factor), and the siRNA to target the coding region of the gene in different human tumor cell lines. Our results indicate that the combined approach is much more efficient than the amiR or siRNA approach alone in knocking down the targeted gene and sensitizing human tumor cells to IR-induced killing. The amiR decreased the targeted gene through reducing the mRNA stability and blocking the translation. These results demonstrate that the combined approach could be used for many different purposes to knock down genes in different cell lines, especially genes that are difficult to knock down using amiR or siRNA alone. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1106. doi:1538-7445.AM2012-1106
Abstract 4539: Androgen receptor N-term death domains induce apoptosis through a bax-mediated mitochondrial pathway
Authors: Bonnie Haferkamp, Yuting Lin, Brad Godfrey, Jialing Xiang
Journal: Cancer Research (2011)

Abstract While the DNA- and ligand-binding domains of the androgen receptor (AR) have been extensively studied to elucidate AR transcriptional mechanisms in androgen-independent prostate cancer, the role of the N-terminal is poorly understood. Previously, we showed that AR is required for stress-induced cell death in androgen-independent prostate cancer cells, and that cell death does not require AR transcriptional activity. Here we show that N-term AR is sufficient to induced cell death in androgen-independent prostate cancer PC3 cells without death stimulus. The minimal death domain is located in the first 85 amino acids of AR, rich in polyQ. The pro-death activities of full length AR and its N-term truncated proteins act through the Bax-mitochondrial apoptotic pathway. Electronic microscope imaging revealed mitochondrial swelling in PC3 cells transfected with death-inducing AR truncated constructs, but not with constructs that failed to induce cell death. Cell death induced by AR N-term truncated constructs can be effectively blocked by caspase 3, but not caspase 1 inhibitor. Finally, transfection of AR death-active N-term truncations caused significant cell death in Bax wild-type but not Bax-/- MEFs. Taken together, these results indicate that pro-death AR N-term fragments generated by stress-induced proteolysis cause cell death through a Bax-dependent mechanism involving the mitochondrial apoptosis pathway in androgen-independent prostate cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4539. doi:10.1158/1538-7445.AM2011-4539
Blood Pressure in Relation to Concentrations of PCB Congeners and Chlorinated Pesticides
Authors: Alexey Goncharov, Marian Pavuk, Herman R. Foushee, David O. Carpenter
Journal: Environmental Health Perspectives (2010)

Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed.The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB groups with common actions or structure, 35 individual PCB congeners, and nine chlorinated pesticides.Linear regression analysis was used to determine the relationships between blood pressure and serum levels of the various contaminants after adjustment for age, body mass index, sex, race, smoking, and exercise in 394 Anniston residents who were not taking antihypertensive medication.Other than age, total serum PCB concentration was the strongest determinant of blood pressure of the covariates studied. We found the strongest associations for those PCB congeners that had multiple ortho chlorines. We found the associations over the full range of blood pressure as well as in those subjects whose blood pressure was in the normal range. The chlorinated pesticides showed no consistent relationship to blood pressure.In this cross-sectional study, serum concentrations of PCBs, especially those congeners with multiple ortho chlorines, were strongly associated with both systolic and diastolic blood pressure.
Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis
Authors: Janneke Landheer, Barbara Giovannone, Jeanine D. Mattson, Sandra Tjabringa, Carla A.F.M. Bruijnzeel-Koomen, Terrill McClanahan, Rene de Waal Malefyt, Edward Knol, DirkJan Hijnen
Journal: Journal of Allergy and Clinical Immunology (2013)
TCT-448 Long-Term Clinical Results Of SeQuent Please Paclitaxel-Coated Balloon Angioplasty For The Treatment Of In-Stent Restenosis
Authors: Javier Benezet, Ignacio Sanchez-Perez, Fernando Lozano, Felipe Higuera, Natalia Pinilla, Yasser Hessein
Journal: Journal of the American College of Cardiology (2013)
Indications and Limitations of Afamelanotide for Treating Vitiligo
Authors: Thierry Passeron
Journal: JAMA Dermatology (2015)

ontheuseofafamelanotideincombinationwithnarrowbandUV-Bfor treating vitiligo. So far, there is no truly satisfactory treat-mentforvitiligo,soanynewapproachismostwelcome.How-ever,thisstudyraisesseveralissues.Afamelanotidebindswiththemelanocortin-1receptor(MC1R),whichisthereceptorup-streamofoneofthekeypathwaysformelanogenesis.
Prevalence of diabetes in a predominantly Asian community: preliminary findings of the Coventry diabetes study.
Authors: D. Simmons, D. R. Williams, M. J. Powell
Journal: BMJ (1989)

To assess the prevalence of both diagnosed and undiagnosed diabetes mellitus in an area of predominantly Asian population the Coventry diabetes study is carrying out house to house screening for diabetes in people aged 20 and over in Foleshill, Coventry. In the first five of 12 areas to be studied 2130 of 2283 Asian (93.3%) and 1242 of 1710 white subjects (72.6%) aged 20-79 agreed to be screened. The prevalence of diabetes adjusted to 1987 demographic estimates was 11.2% in Asian men and 8.9% in Asian women whereas it was 2.8% in white men and 4.3% in white women. The excess of diabetes in Asian subjects was predominantly of non-insulin-dependent diabetes, and no significant differences in body mass were found to account for the higher prevalence. Diabetes had not been diagnosed previously in at least 26% of the white and 30% of the Asian diabetics screened, and it is estimated that in this community the condition remains undiagnosed in 42% of white and 40% of Asian diabetics.
The Psychology of Postponement in the Medical Marriage
Authors: Jeanne Henning
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Drs Gabbard and Menninger<sup>1</sup>make some accurate observations in their article when they describe the psychology of postponement in medical marriage. The demands of medical practice eventually lead to the demise of marital happiness, exactly as they describe. My former marriage of 11 years bears mute testimony to this. Even though the physician divorce rate may not be any higher than that in other professions,<sup>2</sup>I believe many spouses of physicians stay in these unhappy marriages because the price of leaving is too high. Single women with children often become poor because of divorce. The price for myself and my four children is a life barely above the poverty level. Knowing my family would be poor for many years to come, I sought divorce only when it became clear to me that I could not keep on living in a marriage just going through the
THE PATHOGENESIS OF PARATHYROID TETANY
Authors: LESTER R. DRAGSTEDT
Journal: JAMA (1922)

The anatomic and functional independence of the thyroid and the parathyroid glands may be regarded as definitely established. It is also certain that the acute nervous manifestations which follow the removal of both organs in carnivorous animals are due to the absence of the parathyroid glands. However, the function of these glands is still an open question, and the pathogenesis of the usually fatal tetany which follows their complete removal is not satisfactorily explained. A number of theories have been advanced from time to time, but since these have been carefully summarized in several recent reviews,<sup>1</sup>reference will be made only to those that have become of interest in my own experiments. In conformance with the prevailing ideas regarding the possible functions of ductless glands, it is possible that the parathyroids contribute some substance to the blood which is necessary for life, and in the absence of which the
IMPACT OF LONG-TERM STATIN THERAPY ON POST-PROCEDURAL CONTRAST-INDUCED NEPHROPATHY IN PATIENTS UNDERGOING NON-EMERGENCY PERCUTANEOUS CORONARY INTERVENTION
Authors: David Yang, Muhammad Haider, Luke Kim, Rajesh Swaminathan, Konstantinos Charitakis, Ashish Shah, Ryan Kaple, Robert Minutello, Harsimran Singh, Geoffrey Bergman, Shing-Chiu Wong, Dmitriy Feldman
Journal: Journal of the American College of Cardiology (2014)
CONTROL OF POSTPARTUM HEMORRHAGE
Authors: Ernest Myller
Journal: JAMA (1952)

Hemorrhage is one of the most frequent causes of postpartum death. Statistics being reliable only from larger hospitals, we may assume that many postpartum deaths are either unreported or designated otherwise. In a report from the Mayo Clinic,<sup>1</sup>the incidence of death from hemorrhage is 0.491 per 1,000 births, an average of 1 case per 2,000 deliveries. Postpartum hemorrhage in a large Brooklyn hospital caused death in 34 of 37 cases of obstetric fatality. It can only be conjectured how many more occur in institutions with lower standards. There are standard methods of treating postpartum hemorrhage. It must be assumed from the poor results reported that they are not always successful. The usual routine procedure is to endeavor to find out whether the uterus is empty or to establish other causes for the bleeding. By the time the examination is completed, the hemorrhage may become alarming. Posterior pituitary (pituitrin®)
Closing the gap: The tight junction protein occludin and hepatitis C virus entry
Authors: Nicholas S. Eyre, Thomas F. Baumert, Michael R. Beard, Kris Kowdley, Geoffrey McCaughan, Christian Trautwein
Journal: Hepatology (2009)

Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. The development of much needed specific antiviral therapies and an effective vaccine has been hampered by the lack of a convenient small animal model. The determinants restricting HCV tropism to human and chimpanzee hosts are unknown. Replication of the viral RNA has been demonstrated in mouse cells, but these cells are not infectable with either lentiviral particles bearing HCV glycoproteins (HCVpp) or HCV produced in cell culture (HCVcc) (A.P., M.E. and C.M.R., unpublished observations), suggesting that there is a block at the level of entry. Here we show, using an iterative complementary DNA library screening approach, that human occludin (OCLN) is an essential HCV cell entry factor that is able to render murine cells infectable with HCVpp. Similarly, OCLN is required for the HCV-susceptibility of human cells, because its overexpression in uninfectable cells specifically enhanced HCVpp uptake, whereas its silencing in permissive cells impaired both HCVpp and HCVcc infection. In addition to OCLN, HCVpp infection of murine cells required expression of the previously identified HCV entry factors CD81 (ref. 4), scavenger receptor class B type I (SR-BI, also known as SCARB1) and claudin-1 (CLDN1). Although the mouse versions of SR-BI and CLDN1 function at least as well as the human proteins in promoting HCV entry, both OCLN and CD81 must be of human origin to allow efficient infection. The species-specific determinants of OCLN were mapped to its second extracellular loop. The identification of OCLN as a new HCV entry factor further highlights the importance of the tight junction complex in the viral entry process, and provides an important advance towards efforts to develop small animal models for HCV.
"Pseudoanaphylactic" Reactions from Inadvertent Infusion of Procaine Penicillin G
Authors: JEFFREY E. GALPIN
Journal: Annals of Internal Medicine (1974)

Acute, nonallergic reactions simulating anaphylaxis have been reported after intramuscular injections of aqueous procaine penicillin G, and it has been assumed that the antibiotic inadvertently reaches the intravascular space during the injection. We report three patients in whom the classical "pseudoanaphylactic" reactions occurred after inadvertent administration of aqueous procaine penicillin G by intravenous infusion. Cardiorespiratory arrest with slow idioventricular rhythm and acute anxiety reactions with tinnitis and dizziness were observed within 15 minutes of the infusion in these patients. Microembolization to the lungs and brain, as well as direct toxicity from the procaine component of aqueous procaine penicillin G, are probably the pathogenetic mechanisms. Our experience with three patients within 12 months suggests that this complication may be more frequent than might be surmised from the literature, and medical personnel should be alerted to this potentially lethal reaction.
Points: McIlroy: in memoriam
Authors: B. O'Shea, A. McGennis
Journal: BMJ (1983)

This article provides a comprehensive review of the literature on emerging market debt securities. Compared to the developed world, this segment of the bond market is less established, both for the types of securities that are issued and for the entities that issue them. The literature reflects that. The focus of research on emerging debt markets has evolved over time along with the changes in the composition of the market. This review covers the modern era, from the early 1990s up to today, yet includes a lookback at foregone times.
Use of activity measures in behavioral toxicology.
Authors: L Reiter
Journal: Environmental Health Perspectives (1978)

Locomotor activity measurements have been used extensively to evaluate chemically-induced changes in CNS function. This paper focuses on several factors including apparatus, age, biological rhythm, and social setting, which influence both locomotor activity levels per se and chemically induced changes in these activity levels. These data illustrate that failure to recognize, specify, and consider these factors is likely to result in equivocal studies subject to possible misinterpretation.
Monitoring of mite <i>Dermatophagoides farinae</i> allergen‐specific IgG and IgG subclass distribution in patients on immunotherapy
Authors: R. Einarsson, S. Dreborg, L. Hammarström, T. Löfkvist, C. I. E. Smith, G. Svensson
Journal: Allergy (1992)

House dust mite D. farinae and Der f II-specific IgG and IgG subclass responses were evaluated in 32 adults with perennial rhinitis undergoing immunotherapy for 1 year by means of IgG-RAST and ELISA. The ELISA method, which is based on subclass-specific monoclonal antibodies, could detect 0.5-1.5 ng/ml of specific antibodies. D. farinae and Der f II-specific IgG4 antibodies increased continuously as immunotherapy proceeded, while total IgG and IgG1 antibodies reached a plateau value 6 months after the start of immunotherapy, followed by a slow decrease during maintenance therapy. During the early phase of treatment the concentration of IgG1 and IgG4 antibodies rose, even though the increase of IgG4 antibodies dominated. The positive clinical outcome as measured by the decrease in conjunctival sensitivity was associated with an increased ratio of specific IgG4/IgG1 antibodies as well as the magnitude of the IgG4 subclass response. Quantitation of IgG subclass antibodies in patients undergoing immunotherapy may be of some clinical value, but the clinical usefulness needs to be demonstrated for each type of allergen and possibly also for each assay system.
Screening to prevent heart failure (STOP‐HF): expanding the focus beyond asymptomatic left ventricular systolic dysfunction
Authors: Gillian Murtagh, Ian R. Dawkins, Ronan O'Connell, Mallikarjuna Badabhagni, Anil Patel, Elaine Tallon, Rory O'Hanlon, Mark T. Ledwidge, Kenneth M. McDonald
Journal: European Journal of Heart Failure (2012)
Terminal plasmocytoid differentiation of malignant B cells induced by autotumor-reactive CD4+ T cells in one case of splenic marginal zone B-cell lymphoma
Authors: Thierry Bonnefoix, Jian-Qing Mi, Pascal Perron, Mary Callanan, Cosima Semoun, Mireille Favre, Jean-Charles Renversez, Marie-France Sotto, Dominique Leroux, Jean-Jacques Sotto
Journal: Blood (2002)
Risk of overdiagnosis doesn't deter women from breast cancer screening, study finds
Authors: Z. Kmietowicz
Journal: BMJ (2013)

Although women have been found to be surprised and shocked that mammography could lead to “overdiagnosis,” they would rather attend screening than risk missing a treatable cancer, new research has found.

The study, funded by Cancer Research UK, used focus groups involving 40 women aged between 50 and 71 years old who were based in and around London, some of whom had already been screened and others who had not attended for screening.1

The researchers gave the participants information on breast screening and the possibility of overdiagnosis, defined as a proportion of slower growing cancers diagnosed through screening that might never …
A World Beyond Healing: The Prologue and Aftermath of Nuclear War
Authors: Gordon K. MacLeod
Journal: JAMA (1988)

No one, except perhaps a journalist, could be bold enough to discuss the outcome of nuclear warfare on the world as well as its myriad effects—physical, biologic, psychological, community, social, medical, and public health; military, strategic, political, and economic. Nevertheless, Nicholas Wade, now a member of the editorial board of the<i>New York Times</i>, has done just that in a readable and compelling little book that contains much worthwhile information. Wade says Hiroshima and Nagasaki's "physical scars of war, even nuclear scars, have completely healed." But even more significantly, Wade reflects on the deterrence of further nuclear war subsequent to the Nagasaki bombing, which has succeeded—so far. The author expresses obvious concern about the fragile nature of nuclear deterrence because so little deviation is allowed from prearranged contingency plans. Even in the event of the unlikely possibility that one side believes the other is about to strike first, a crisis
OKT3 vs HATG tolerance induction in heart allograft recipients in serial 6 month followup: Differential impact on serum levels of soluble IL-2 receptors
Authors: Maria Rosa Costagnzo-Nordin, Joshua A. Engel, Janet E. Wilson, Lawrence H. Chow, E.Jeanne O'Sullivan, Roque Pifarre, Bruce M. McManus
Journal: Journal of the American College of Cardiology (1990)
Direct Intramuscular Injection of Plasmid DNA Encoding Angiopoietin-1 but not Angiopoietin-2 Augments Revascularization in the Rabbit Ischemic Hindlimb
Authors: Kou-Gi Shyu, Orit Manor, Meredith Magner, George D. Yancopoulos, Jeffrey M. Isner
Journal: Circulation (1998)

Background —Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) have recently been identified as ligands for the endothelial cell–specific Tie2 receptor. Little is known regarding the impact of these Tie2 ligands on postnatal neovascularization. Accordingly, we tested the hypothesis that gene transfer of plasmid DNA encoding Ang1 and Ang2 could modulate collateral vessel development in a rabbit model of hindlimb ischemia. Methods and Results —pAng1* (n=15), pJFE control (no Ang1* insert) (n=9), pAng2 (n=9), pcDNA3 control (no Ang2 insert) (n=10), or saline (n=5) was injected intramuscularly into the rabbit ischemic hindlimb. Collateral vessel development and limb perfusion were assessed before and 30 days after treatment. Calf blood pressure ratio (ischemic to normal hindlimb) was increased 30 days after Ang1* gene transfer versus controls (Ang1*, 0.90±0.02; pJFE, 0.76±0.05; saline, 0.77±0.03; P &lt;0.05). Angiographic score was higher ( P &lt;0.05) in the pAng1* group (0.63±0.02) than in the pJFE (0.51±0.03) or saline (0.52±0.02) group. Maximal (postpapaverine) blood flow in the ischemic limb was higher ( P &lt;0.05) after pAng1* (67.8±4.9 mL/min) than pJFE (51.2±4.4 mL/min) or saline (52.9±4.9 mL/min). Capillary density and capillary/muscle fiber ratio (242±12/mm 2 and 0.89±0.06, respectively) were higher ( P &lt;0.01) with pAng1* than pJFE (172±11/mm 2 and 0.64±0.05) or saline (166±10/mm 2 and 0.67±0.05). Neovascularization was not enhanced with pAng2. Conclusions — Ang1 but not Ang2 gene transfer produces anatomic and physiological evidence of enhanced collateral vessel formation. Ang1 may modulate neovascularization in adult animals and thus represents a feasible therapeutic strategy for patients with tissue ischemia. The role of Ang2 in postnatal neovascularization remains to be clarified.