Glucagon and the Cardiovascular System
Authors: JOHN F. WILLIAMS
Journal: Annals of Internal Medicine (1969)

Editorials1 August 1969Glucagon and the Cardiovascular SystemJOHN F. WILLIAMS JR., M.D., F.A.C.P.JOHN F. WILLIAMS JR., M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-2-419 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1960 Farah and Tuttle (1) reported that crystalline glucagon exerted positive inotropic and chronotropic effects on isolated hearts of the dog, the rat, the guinea pig, and the cat. Surprisingly there was little further interest in these potentially useful actions until recently. In the past few months a number of papers have substantiated the early observations of Farah and Tuttle and expanded considerably our knowledge of the cardiovascular effects of glucagon as well as the mechanisms by which these effects are produced. In addition, studies of the cardiovascular actions recently have been extended to man, and reports have appeared...References1. FARAH A and TUTTLE R: Studies on the pharmacology of glucagon. J. Pharmacol. Exp. Ther. 129: 49, 1960. MedlineGoogle Scholar2. GLICK G, PARMLEY WW, WECHSLER AS, and SONNENBLICK EH: Glucagon. Its enhancement of cardiac performance in the cat and dog and persistence of its inotropic action despite beta-receptor blockade with propranolol. Circ. Res. 22: 789, 1968. CrossrefMedlineGoogle Scholar3. LUCCHESI BR: Cardiac actions of glucagon. Ibid., p. 777. Google Scholar4. REGAN TJ, LEHAN PH, HENNEMAN DH, BEHAR A, and HELLEMS HK: Myocardial metabolic and contractile response to glucagon and epinephrine. J. Lab. Clin. Med. 63: 638, 1964. MedlineGoogle Scholar5. WHITEHOUSE FW and JAMES TN: Chronotropic action of glucagon on the sinus node. Proc. Soc. Exp. Biol. Med. 122: 823, 1966. CrossrefMedlineGoogle Scholar6. LARAIA PJ, CRAIG RJ, and REDDY WJ: Glucagon: Effect on adenosine 3', 5'-monophosphate in the rat heart. Amer. J. Physiol. 215: 968, 1968. CrossrefMedlineGoogle Scholar7. WHITSITT LS and LUCCHESI BR: Effects of betareceptor blockade and glucagon on the atrioventricular transmission system in the dog. Circ. Res. 23: 585, 1968. CrossrefMedlineGoogle Scholar8. STEINER C, WIT AL, and DAMATO AN: Effects of glucagon on atrioventricular conduction and ventricular automaticity in dogs. Circ. Res. 24: 167, 1969. CrossrefMedlineGoogle Scholar9. LIPSKI JI, KAMINSKY DM, DONOSO E, and FRIEDBERG CK: The electrophysiologic properties of glucagon on the normal canine heart (abstract). Amer. J. Cardiol. 23: 124, 1969. CrossrefGoogle Scholar10. GREENSPAN K, EDMANDS RE, and FISCH C: Electrophysiologic aspects of glucagon inotropy (abstract). Ibid., p. 116. Google Scholar11. KREISBERG RA and WILLIAMSON JR: Metabolic effects of glucagon in the perfused rat heart. Amer. J. Physiol. 207: 721, 1964. CrossrefMedlineGoogle Scholar12. CORNBLATH M, RANDLE PJ, PARMEGGIANI A, and MORGAN HE: Regulation of glycogenolysis in muscle. Effects of glucagon and anoxia on lactate production, glycogen content, and phosphorylase activity in the perfused isolated rat heart. J. Biol. Chem. 238: 1592, 1963. CrossrefMedlineGoogle Scholar13. SUTHERLAND EW and RALL TW: The relation of adenosine-3', 5'-phosphate and phosphorylase to the actions of catecholamines and other hormones. Pharmacol. Rev. 12: 265, 1960. Google Scholar14. LEVEY GS and EPSTEIN SE: Activation of adenyl cyclase by glucagon in cat and human heart. Circ. Res. 24: 151, 1969. CrossrefMedlineGoogle Scholar15. PARMLEY WW, GLICK G, and SONNENBLICK EH: Cardiovascular effects of glucagon in man. New Eng. J. Med. 279: 12, 1968. CrossrefMedlineGoogle Scholar16. KLEIN SW, MORCH JE, and MAHON WA: Cardiovascular effects of glucagon in man. Canad. Med. Ass. J. 98: 1161, 1968. MedlineGoogle Scholar17. LINHART JW, BAROLD SS, COHEN LS, HILDNER FJ, and SAMET P: Cardiovascular effects of glucagon in man. Amer. J. Cardiol. 22: 706, 1968. CrossrefMedlineGoogle Scholar18. WILLIAMS JF, CHILDRESS RH, CHIP JN, and BORDER JF: Hemodynamic effects of glucagon in patients with heart disease. Circulation 39: 38, 1969. CrossrefMedlineGoogle Scholar19. BROGAN E, KOZONIS MC, and OVERY DC: Glucagon therapy in heart-failure. Lancet 1: 482, 1969. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN F. WILLIAMSJR., M.D., F.A.C.P.Affiliations: Veterans Administration Hospital Indiana University School of Medicine Indianapolis, Ind. 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