tbuckley/cabot-search huggingface dataset:
Hepatic steatosis and steatohepatitis in human immunodeficiency virus/hepatitis C virus-coinfected patients
Authors: Juan Macías, Juan Berenguer, Miguel A. Japón, José A. Girón-González, Antonio Rivero, Luis F. López-Cortés, Ana Moreno, Manuel Márquez, José A. Iribarren, Enrique Ortega, Pilar Miralles, Nicolás Merchante, Juan A. Pineda
Journal: Hepatology (2012)

Hepatic steatosis (HS) is frequent in human immunodeficiency virus (HIV)- and hepatitis C virus (HCV)-coinfected patients. Antiretroviral therapy (ART) and metabolic alterations could induce HS. However, a protective effect of ART has been reported in a paired biopsy study. Thus, our aim was to examine the changes and predictors of HS progression among HIV/HCV-coinfected patients with sequential biopsies. We also evaluated the rates of steatohepatitis and factors associated thereof. HIV-infected patients with detectable serum HCV RNA, who underwent two biopsies, separated at least by 1 year, were included in this retrospective study. HS progression was defined as increase in one or more HS grades. The median (interquartile range) time between biopsies was 3.3 (2.0-5.2) years. Among 146 individuals, HS at baseline was observed in 86 (60%) patients and in 113 (77%) in the follow-up biopsy (P < 0.001). Progression of HS was observed in 60 (40%) patients. HS regressed in 11 (8%) patients. Factors associated with HS progression were changes in fasting plasma glucose (FPG) between biopsies (per 10 mg/dL increase; odds ratio [OR] [95% confidence interval; CI] = 1.4 [1.04-1.8]; P = 0.024) and cumulative use of dideoxynucleoside analogs (per year; OR [95% CI] = 1.5 [1.2-1.8]; P = 0.001). Persistent steatohepatitis or progression to steatohepatitis between biopsies was observed in 27 (18%) patients. Persistence of or progression to steatohepatitis was associated with progression ≥ 1 fibrosis stages between biopsies (OR [95% CI] = 2.4 [1.01-5.7]; P = 0.047).HS progresses frequently and regression is rarely observed in HIV/HCV-coinfected patients, including in those on ART. Cumulative exposure to dideoxynucleoside analogs and increases in FPG are related with HS progression. Stetatohepatitis is frequently observed in these patients and is linked to fibrosis progression.
"CURRENT CRITICISMS OF MEDICAL EDUCATION"
Authors: Cleaves Bennett
Journal: JAMA (1924)

<h3>To the Editor:</h3> —I have read with much interest the communication of Dr. William Allen Pusey concerning criticism of medical education (The Journal, August 9). I hope this matter will be threshed out until there is a clear understanding of a real and very serious situation. One of the best men among Chicago medical teachers said all this to me, and more, within the last year. Apparently each school is so afraid that its prestige might be damaged that it follows without protest along the path of education which has been laid out for it in the last fifteen or twenty years and which, to say the least, is leading into a bad situation. I have been in active general practice twenty-eight years, fifteen of them in a town of 10,000 where we had no hospital for eight years, and the last thirteen in a well equipped college community of
Palmoplantar keratoderma, deafness and atopy
Authors: J. Verbov
Journal: British Journal of Dermatology (1987)

Journal Article Palmoplantar keratoderma, deafness and atopy Get access J. Verbov J. Verbov Royal Liverpool Children's Hospital, City Branch, Myrtle Street, Liverpool L7 7DG, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 116, Issue 6, 1 June 1987, Page 881, https://doi.org/10.1111/j.1365-2133.1987.tb04914.x Published: 01 June 1987
Does Development Assistance for Health Really Displace Government Health Spending? Reassessing the Evidence
Authors: Rajaie Batniji, Eran Bendavid
Journal: PLoS Medicine (2012)

Retraction: Batniji R, Bendavid E (2012) Does Development Assistance for Health Really Displace Government Health Spending? Reassessing the Evidence. PLoS Med 9(5): e1001214. doi:10.1371/journal.pmed.1001214
Patterns of Failure after Stereotactic Body Radiation Therapy or Lobar Resection for Clinical Stage I Non–Small-Cell Lung Cancer
Authors: Cliff G. Robinson, Todd A. DeWees, Issam M. El Naqa, Kimberly M. Creach, Jeffrey R. Olsen, Traves D. Crabtree, Bryan F. Meyers, Varun Puri, Jennifer M. Bell, Parag J. Parikh, Jeffrey D. Bradley
Journal: Journal of Thoracic Oncology (2013)
Doctors warn of dangers of the internet
Authors: T. Rutter
Journal: BMJ (1998)

Sending emails to medical based sites on the worldwide web may not be the best or the fastest way to get personal medical information, concludes a new study in this week's JAMA (the journal of the American Medical Association).

The study was conducted by Gunther Eysenbach, and Thomas Diepgen from the University Hospital Erlangen, who evaluated the possible responses received by people who seek medical advice through email messages to medically oriented …
Enhanced A-FABP expression in visceral fat: potential contributor to the progression of NASH
Authors: Min Yong Yoon, Jun Mo Sung, Chang Seok Song, Won Young Lee, Eun Jung Rhee, Jun Ho Shin, Chang Hak Yoo, Seoung Wan Chae, Ja Yeon Kim, Wook Jin, Yong Kyun Cho
Journal: Clinical and Molecular Hepatology (2012)

Background/Aims Adipose tissue is an active endocrine organ that secretes various metabolically important substances including adipokines, which represent a link between insulin resistance and nonalcoholic steatohepatitis (NASH). The factors responsible for the progression from simple steatosis to steatohepatitis remain elusive, but adipokine imbalance may play a pivotal role. We evaluated the expressions of adipokines such as visfatin, adipocyte-fatty-acid-binding protein (A-FABP), and retinol-binding protein-4 (RBP-4) in serum and tissue. The aim was to discover whether these adipokines are potential predictors of NASH. Methods Polymerase chain reaction, quantification of mRNA, and Western blots encoding A-FABP, RBP-4, and visfatin were used to study tissue samples from the liver, and visceral and subcutaneous adipose tissue. The tissue samples were from biopsy specimens obtained from patients with proven NASH who were undergoing laparoscopic cholecystectomy due to gallbladder polyps. Results Patients were classified into two groups: NASH, n=10 and non-NASH, n=20 according to their nonalcoholic fatty liver disease Activity Score. Although serum A-FABP levels did not differ between the two groups, the expressions of A-FABP mRNA and protein in the visceral adipose tissue were significantly higher in NASH group than in non-NASH group (104.34 vs. 97.05, P<0.05, and 190.01 vs. 95.15, P<0.01, respectively). Furthermore, the A-FABP protein expression ratio between visceral adipose tissue and liver was higher in NASH group than in non-NASH group (4.38 vs. 1.64, P<0.05). Conclusions NASH patients had higher levels of A-FABP expression in their visceral fat compared to non-NASH patients. This differential A-FABP expression may predispose patients to the progressive form of NASH. Keywords: NASH; Adipocyte-fatty-acid-binding protein; Retinol-binding protein-4; Visfatin; PCR; Western blot
A coagulation pathway on bovine aortic segments leading to generation of Factor Xa and thrombin.
Authors: D M Stern, P P Nawroth, W Kisiel, D Handley, M Drillings, J Bartos
Journal: Journal of Clinical Investigation (1984)

Previous studies have demonstrated the binding of Factors IX and IXa to cultured bovine aortic endothelial cells. The present study examines the interaction of Factors IX, IXa, and Xa with the luminal surface of calf aortas, shown by microscopic examination to have a continuous layer of endothelium. Radioimmunoassay of Factor IX showed that 74 fmol/10(6) cells of Factor IX could be eluted from freshly prepared aortic segments. Binding of 3H-Factors IX and IXa to aortic segments was saturable, and comparable to binding in previous studies using cultured endothelial cells. Preincubation of aortic segments with 3H-Factor IXa and von Willebrand factor (VWF)/Factor VIII, followed by washing and addition of Factor X, resulted in formation of Factor Xa. The addition of prothrombin to these activation mixtures resulted in formation of thrombin. Exogenous phospholipid and Factor V were not required for Factor X and prothrombin activation on the intact native endothelium. Incubation of 125I-Factor Xa with the vessel segments resulted in most of the tracer being complexed with antithrombin III originally present on the aortic segment (3.8 pmol antithrombin III/10(6) cells). The Factor Xa-antithrombin III complex was observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis exclusively in the supernatants. 125I-Factor Xa not complexed with antithrombin III bound specifically to the vessel segment. The time course of binding was biphasic, consisting of an initial more rapid reversible phase followed by a slower irreversible phase. The latter phase correlated with the formation of a covalent complex (Mr, 76,000) between 125I-Factor Xa and a vessel-localized protein presumably distinct from antithrombin III. The activation of prothrombin by vessel-bound Factor Xa was inhibited by anti-bovine Factor V IgG, suggesting that there is interaction of Factor Xa with a Factor V-like molecule provided by the endothelial cell surface. Addition of antibody to antithrombin III prevented formation of Factor Xa-antithrombin III and thrombin-antithrombin III complexes in the supernatant and increased apparent thrombin activity 30-50-fold. These studies demonstrate that freshly obtained vessels with a continuous layer of native endothelium can support activation of Factor X and prothrombin: vessel-bound Factor IXa can activate Factor X in the presence of VWF/Factor VIII. Factor Xa can also bind to the vessel and participate in the activation of prothrombin. The apparent efficiency of prothrombin activation, however, is dampened by the presence of functional antithrombin III on the vessel wall.
The Cholera: A New Method of Treatment
Authors: H. C. Taylor
Journal: BMJ (1883)

THE 'BBRIISH MEDICAL JO URNAL.69 of calcium phosphate within the bladder, and upon the formation of urinary calculi, as showing how, phosphatic precipitation may take place in a feebly acid condition of the urine.Fuller details will appear in a paper to be published in an early number of the Dub&iz T&urnal of Medical Sience.
Adult and Pediatric Resuscitation
Authors: Linda Quan
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adult Still's disease
Authors: W.G. PHILLIPS, R. WELLER, S.E. HANDFIELD-JONES, A. KOBZA-BLACK
Journal: British Journal of Dermatology (1994)

Adult Still's disease (ASD) is a rare disorder of unknown aetiology, characterized by an evanescent, erythematous, maculopapular rash, fever, arthralgia, and a variety of systemic features. We report a case which illustrates the typical features of ASD, and manifests the hitherto unreported complication of diffuse cutaneous mucinosis.
Letter: cost of going metric.
Authors: D Nelson
Journal: BMJ (1975)

tumour, and this was significantly different (X2 with Yates's correction = 11-18, P<0001) from histopathologically reactive pa,tients.Though it is too soon to assess our results in terms of patients' survival, we would like to suggest that histopa,thological analysis of tumour and lymph nodes might provide an alternative when skin testing is not feasible.-We are, etc.,
Use of Medical Consultants for Hospitalized Surgical Patients
Authors: Lena M. Chen, Adam S. Wilk, Jyothi R. Thumma, John D. Birkmeyer, Mousumi Banerjee
Journal: JAMA Internal Medicine (2014)

Payments around episodes of inpatient surgery vary widely among hospitals. As payers move toward bundled payments, understanding sources of variation, including use of medical consultants, is important.To describe the use of medical consultations for hospitalized surgical patients, factors associated with use, and practice variation across hospitals.Observational retrospective cohort study of fee-for-service Medicare patients undergoing colectomy or total hip replacement (THR) between January 1, 2007, and December 31, 2010, at US acute care hospitals.Number of inpatient medical consultations.More than half of patients undergoing colectomy (91,684) or THR (339,319) received at least 1 medical consultation while hospitalized (69% and 63%, respectively). Median consultant visits from a medicine physician were 9 (interquartile range [IQR], 4-19) for colectomy and 3 for THR (IQR, 2-5). The likelihood of having at least 1 medical consultation varied widely among hospitals (interquartile range [IQR], 50%-91% for colectomy and 36%-90% for THR). For colectomy, settings associated with greater use included nonteaching (adjusted risk ratio [ARR], 1.14 [95% CI, 1.04-1.26]) and for-profit (ARR, 1.10 [95% CI, 1.01-1.20]). Variation in use of medical consultations was greater for colectomy patients without complications (IQR, 47%-79%) compared with those with complications (IQR, 90%-95%). Results stratified by complications were similar for THR.The use of medical consultations varied widely across hospitals, particularly for surgical patients without complications. Understanding the value of medical consultations will be important as hospitals prepare for bundled payments and strive to enhance efficiency.
Prevalence, Diagnosis, and Profile of Autoimmune Pancreatitis Presenting with Features of Acute or Chronic Pancreatitis
Authors: Raghuwansh P. Sah, Rahul Pannala, Suresh T. Chari, Aravind Sugumar, Jonathan E. Clain, Michael J. Levy, Randall K. Pearson, Thomas C. Smyrk, Bret T. Petersen, Mark D. Topazian, Naoki Takahashi, Santhi S. Vege
Journal: Clinical Gastroenterology and Hepatology (2009)
(3) Focal dermal hypopiasia (Goltz? syndrome)
Authors: H.K. Shamy
Journal: British Journal of Dermatology (1987)

Journal Article (3) Focal dermal hypopiasia (Goltz? syndrome) Get access H.K. Shamy H.K. Shamy York District Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 48–49, https://doi.org/10.1111/j.1365-2133.1987.tb12044.x Published: 01 June 1987
INCIDENCE AND PREDICTORS OF PLEURITIC CHEST DISCOMFORT FOLLOWING ABLATION OF ATRIAL FIBRILLATION
Authors: Blake Evan Fleeman, Stuart Beldner, David Katz, David Steckman, Ryan Aleong, Duy Nguyen, Joseph Schuller, Raphael Sung, Wendy Tzou, Paul Varosy, William Sauer
Journal: Journal of the American College of Cardiology (2013)
Relationships among residual β cells, exocrine pancreas, and islet cell antibodies in insulin-dependent diabetes mellitus
Authors: Koji Nakanishi, Tetsuro Kobayashi, Hikari Miyashita, Minoru Okubo, Tadao Sugimoto, Toshio Murase, Kinori Kosaka, Mitsuru Hara
Journal: Metabolism (1993)
Methods for managing the increased workload in anticoagulant clinics
Authors: F C Taylor, M E Ramsay, A Renton, H Cohen
Journal: BMJ (1996)

Following evidence of clinical benefit in non-rheumatic atrial fibrillation,1 increasing numbers of patients with cardiac conditions are being referred to outpatient anticoagulant clinics, necessitating review of existing services.2 In one anticoagulant clinic in a north London hospital the number of new patients referred increased by 27% and clinic attendances by 77% between 1991 and 1993. Methods for managing this increase have been reported,2 3 but we have developed a system which can operate within existing resources by selecting patients requiring consultation with a clinic doctor.

A weekly anticoagulant clinic was administered by a phlebotomist with the help of two health care assistants, and all patients were seen by the clinic doctors (a consultant haematologist and a registrar) for dosing and counselling. In 1991 a …
ELABORATION OF DESOXYRIBONUCLEASE BY STREPTOCOCCI IN THE RESTING STATE AND INHIBITION OF THE ENZYME BY A SUBSTANCE EXTRACTABLE FROM THE COCCI
Authors: Alan W. Bernheimer, Norma K. Ruffier
Journal: The Journal of Experimental Medicine (1951)

As a preliminary to the study of desoxyribonuclease elaboration by resting cells, 34 strains of streptococci were examined for their capacity to produce desoxyribonuclease in broth cultures. The largest amounts of enzyme were found to be produced by strains belonging to Lancefield group A and by certain strains belonging to groups C and D. Many strains, especially those belonging to other groups, produced little or no enzyme. Washed cocci of certain strains elaborated desoxyribonuclease extracellularly upon suspending them in a solution containing an energy source, phosphate and magnesium ions. When any one of these factors was omitted, no enzyme was produced. The appearance of extracellular desoxyribonuclease was found to be inhibited by a variety of enzyme poisons, and this and other findings indicate that desoxyribonuclease is synthesized in the resting cell system. Cocci were found to contain a substance which partially inhibits the desoxyribonuclease formed by group A strains but which fails to inhibit the desoxyribonuclease formed by strains belonging to groups B and C or to inhibit the desoxyribonuclease derived from yeast, barley, and pancreas. The inhibitor of group A desoxyribonuclease has been identified as streptococcal ribonucleic acid. Preparations of ribonucleic acid derived from yeast differed from streptococcal ribonucleic acid in failing to inhibit the group A desoxyribonuclease.
Portal Venous “Goodies” and Fulminant Viral Hepatitis
Authors: Sheila Sherlock
Journal: New England Journal of Medicine (1976)

Fulminant viral hepatitis is a condition with an appalling mortality. Survival is only 10 to 20 per cent of those reaching the stage of deep coma, when painful stimuli cannot be appreciated. Treatment by corticosteroids, exchange blood transfusion and hemoperfusion through a pig or human liver, or through suitable columns containing active charcoal or by injections of levodopa, may be of some immediate benefit. Such measures may cause the patient to wake up temporarily but have not been followed by a convincing improvement in the overall survival rate. The "nitty-gritty" of the problem is to encourage the remaining viable liver . . .
Weight Control-Reply
Authors: Alexander R. Lucas
Journal: JAMA (1982)

In Reply.—  I appreciate Dr Rubel's letter emphasizing the main thrust of my article: to recognize the high frequency of dietary seesaw patterns. I could not agree more that these unhealthy means of weight control are serious matters for women and for men as well! Those persons who seek professional attention for their aberrant eating patterns are often physically, psychologically, and socially incapacitated.  Accurate information about the prevalence of the disorders is simply not known and is most difficult to obtain. In addition to those who come to medical attention, untold others may be doing themselves irreparable harm. I also agree that the methods are clearly not a way to achieve a satisfactory life. I suggest, however, that an even greater number of persons, apparently well adjusted, are controlling their weight through intermittent fasting, vomiting, and purging. Far from advocating or condoning these behaviors, I lament them, but suspect that
Abstract 2182: Epigenetic regulation and growth suppression by NDN, an imprinted tumor suppressor gene whose expression is decreased in epithelial ovarian cancers
Authors: Hailing Yang, Partha M. Das, Zhen Lu, Yinhua Yu, Rebecca T. Marquez, Warren Liao, Robert C. Bast
Journal: Cancer Research (2012)

Abstract NDN is a monoallelically expressed, maternally imprinted gene located on chromosome 15q11.2. Deletion and uniparental disomy of the NDN gene is causally associated with the Prader-Willi syndrome, a congenital neuro-developmental disorder. Studies of brain development suggest that NDN functions as a suppressor of neuronal growth. Recent studies have shown that NDN gene expression is downregulated in melanoma and urothelial cancers, indicating that it may also act as a tumor suppressor gene. We have now found that NDN gene expression is also downregulated in 50% of 14 ovarian tumors and 9 out of 10 ovarian cancer cell lines. Hypermethylation of 2 CpG sites in NDN promoter was detected in 5 out of 10 cell lines by pyrosequencing, and 5-aza-2′-deoxycytidine treatment revived NDN expression at different levels, suggesting that DNA hypermethylation is one of the mechanisms of NDN downregulation. Re-expression of the NDN gene product Necdin in SKOv3 ovarian cancer cells significantly inhibited growth by clonogenic assays associated with upregulation of caspase-3 activity. Expression of Necdin did not induce autophagy. As SKOv3 cells are p53 null, the mechanism(s) by which Necdin induces cell death is independent of p53 activity. Our observations that Necdin expression is downregulated in majority of ovarian cancers and cancer cell lines and that re-expression of Necdin inhibited cancer cell growth support the notion that NDN is a tumor suppressor gene. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2182. doi:1538-7445.AM2012-2182
Hepatitis G virus infection in hemodialysis patients
Authors: Maurizio Sampietro, Salvatore Badalamenti, Giorgio Graziani, Giovanna Como, Gherardo Buccianti, Noemi Corbetta, Anna Ticozzi, Anna Archenti, Giovanna Lunghi, Donata Penso, Antonio Pizzuti, Gemino Fiorelli, Claudio Ponticelli
Journal: Kidney International (1997)
Typhoid fever in Hong Kong junk family.
Authors: C R Forrest, T T Lee, W K Tsang, S Y Yu
Journal: BMJ (1969)

The epidemiology of enteric fever in Hong Kong is not fully understood.The disease is e ic but cases are d, so that neither water supply nor bulk foodstuffs can be the main vehicles of infection The following account of 11 cases occur- ring in a family group of 23 people illustrates the local clinical variations of typhoid, which, it is suggested, are a factor in the endemicity.HISTORY Tlhe community consists of the mother and father and five unmarried offspring, and two married sons and their wives and 12 children (Fig. 1).The adults live and work on a junk and the younger children who go to school live on a sampan, which is permanently at anchor.The dimeons of these two vessels are 36 by -13j ft. (11by 4 m.) and 14 by 5 ft.(4-3 by 1-5 m.).