tbuckley/cabot-search huggingface dataset:
Abstract 1045: Src-mediated Tyr20 phosphorylation of transferrin receptor 1 (TfR1) promotes its anti-apoptotic effect: A novel function of TfR1 in cancer cells
Authors: Xi Huang, Jinlong Jian, Qing Yang
Journal: Cancer Research (2011)

Abstract Transferrin receptor 1 (TfR1) is highly expressed in cancer cells and its overexpression is widely thought to be a result of the increased requirement of iron uptake for cell growth. In the present study, we have found that two ligands of TfR1, gambogic acid (GA) but not holo-transferrin (Tf) induced apoptosis in breast cancer MDA-MB-231 cells and activated the JNK and p38 signal pathways. Furthermore, PP2, an inhibitor of steroid receptor coactivator (Src), a tyrosine kinase, greatly promoted GA-mediated apoptosis. These results indicate that Src is involved in GA-mediated TfR1-dependent apoptotic pathway. Following immunoprecipitation of TfR1 and immunoblotting of Src or verse versa, TfR1 was found to be associated with Src. This association was further illustrated by their co-localization with confocal fluorescence microscope and shown resulting in constitutive tyrosine phosphorylations of the TfR1. A type II membrane receptor, TfR1 contains a short intracellular N-terminal domain with 61 amino acids. 20YTRF23, the only Tyr(Y) site within the cytoplasmic domain, has been shown as the motif essential for TfR1-Tf complex internalization. To elucidate which Tyr is phosphorylated, we used a Chinese hamster ovary (CHO)-TRVb cell line that does not express TfR1. Point mutation Y20L showed that Tyr20 of TfR1 was the phosphorylation site by Src. Further treatments of wild type and point mutant revealed that it is the Tyr20 phosphorylation that enhanced the anti-apoptotic effects of TfR1 against GA. Our results indicate that in addition to the known function of iron transport, TfR1 has a novel function of regulating cell survival and antiapoptosis through its Tyr20 phosphorylation by Src. This new function is particularly significant and relevant to cancer cells since high expression of TfR1 not only fulfills the requirement of more iron as a co-factor in DNA synthesis but also enhances their survival. This work is supported by R21 CA132684. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1045. doi:10.1158/1538-7445.AM2011-1045
Psychiatric patients less violent when smoking restricted
Authors: L. Hitchen
Journal: BMJ (2008)

Violence and aggressive incidents were cut by almost half when a smoking ban was introduced at one English acute psychiatric hospital.

In data yet to be published, but seen by the BMJ , investigators at Harplands Hospital in North Staffordshire examined all recorded episodes of violence and aggression that staff experienced. They compared all incidents a year before the introduction of a smoke-free hospital policy in April 2006 with those in the year after. Harplands, like other hospitals, introduced a partial ban so that staff and patients could still smoke in designated areas outside the hospital.

The findings come as the Department of Health introduced a complete ban on smoking in all psychiatric hospitals in England from 1 July.

Incidents were divided into groups such as patient to patient or patient …
Eccrine squamous syringometaplasia in intertriginous areas
Authors: R. Valks, G.F. Buezo, E. Daudén, J. Fraga, A. Garcia-Diez
Journal: British Journal of Dermatology (1996)

Journal Article Eccrine squamous syringometaplasia in intertriginous areas Get access R. Valks, R. Valks Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar G.F. Buezo, G.F. Buezo Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar E. Daudén, E. Daudén Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar J. Fraga, J. Fraga Pathology Hospital Universitario de la Princesa Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar A. Garcia‐Diez A. Garcia‐Diez Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 5, 1 May 1996, Pages 984–986, https://doi.org/10.1111/j.1365-2133.1996.tb06347.x Published: 01 May 1996
Gating mechanisms of ATP sensitive potassium channels: implication in reperfusion injury and preconditioning
Authors: C.-Y. Lee
Journal: Cardiovascular Research (1994)

Journal Article Gating mechanisms of ATP sensitive potassium channels: implication in reperfusion injury and preconditioning Get access Chyuan-Yih Lee Chyuan-Yih Lee Department of Physiology, National Yang-Ming Medical College, Shih-Pai, Taipei, Taiwan: Dr C-Y Lee. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 6, June 1994, Pages 729–734, https://doi.org/10.1093/cvr/28.6.729 Published: 01 June 1994 Article history Received: 03 August 1993 Accepted: 03 November 1993 Published: 01 June 1994
Thyroid Hormone Replacement Therapy in Primary Hypothyroidism: A Randomized Trial Comparing <scp>l</scp>-Thyroxine plus Liothyronine with <scp>l</scp>-Thyroxine Alone
Authors: Héctor F. Escobar-Morreale, José I. Botella-Carretero, Manuel Gómez-Bueno, José M. Galán, Vivencio Barrios, José Sancho
Journal: Annals of Internal Medicine (2005)

Background: Substituting part of the dose of l-thyroxine with small but supraphysiologic doses of liothyronine in hypothyroid patients has yielded conflicting results. Objective: To evaluate combinations of l-thyroxine plus liothyronine in hypothyroid patients that match the proportions present in normal secretions of the human thyroid gland. Design: Randomized, double-blind, crossover trial. Setting: Academic research hospital. Participants: 28 women with overt primary hypothyroidism. Intervention: Crossover trial comparing treatment with l-thyroxine, 100 µg/d (standard treatment), versus treatment with l-thyroxine, 75 µg/d, plus liothyronine, 5 µg/d (combination treatment), for 8-week periods. All patients also received l-thyroxine, 87.5 µg/d, plus liothyronine, 7.5 µg/d (add-on combination treatment), for a final 8-week add-on period. Measurements: Primary outcomes included serum thyroid hormone levels, results of quality-of-life and psychometric tests, and patients' preference. Multiple biological thyroid hormone end points were studied as secondary outcomes. Results: Compared with standard treatment, combination treatment led to lower free thyroxine levels (decrease, 3.9 pmol/L [95% CI, 2.5 to 5.3 pmol/L]), slightly higher serum levels of thyroid-stimulating hormone (increase, 0.62 mU/L [CI, 0.01 to 1.23 mU/L]), and unchanged free triiodothyronine levels. No improvement was observed in the other primary and secondary end points after combination treatment, with the exception of the Digit Span Test, in which the mean backward score and the mean total score increased slightly (0.6 digit [CI, 0.1 to 1.0 digit] and 0.8 digit [CI, 0.2 to 1.4 digits], respectively). The add-on combination treatment resulted in overreplacement. Levels of thyroid-stimulating hormone decreased by 0.85 mU/L (CI, 0.27 to 1.43 mU/L) and serum free triiodothyronine levels increased by 0.8 pmol/L (CI, 0.1 to 1.5 pmol/L) compared with standard treatment; 10 patients had levels of thyroid-stimulating hormone that were below the normal range. Twelve patients preferred combination treatment, 6 patients preferred the add-on combination treatment, 2 patients preferred standard treatment, and 6 patients had no preference (P = 0.015). Limitations: Treatment with l-thyroxine, 87.5 µg/d, plus liothyronine, 7.5 µg/d, was an add-on regimen and was not randomized. Conclusions: Physiologic combinations of l-thyroxine plus liothyronine do not offer any objective advantage over l-thyroxine alone, yet patients prefer combination treatment.
Reply to D. Vordermark
Authors: Erin D. Kennedy
Journal: Journal of Clinical Oncology (2010)

We appreciate the comments by Vordermark 1 about our recent contribution to Journal of Clinical Oncology. 2We agree that the Internet certainly has the potential to be an excellent and accessible information resource for both patients and physicians.The results presented by Vordermark et al 3 and Adler et al 4 are both interesting and timely, given that these data suggest that patients seeking information on the Internet are not comfortable discussing the information with their physicians.This is similar to our own group's experience in which patients seem to be increasingly more confident in the information they find on the Internet rather than in their own physicians.This is somewhat concerning, and we must begin to question whether we as physicians are slowly losing the ability to connect with our patients.Given that patient decision aids (pDAs) are effective at improving patient knowledge, it seems reasonable for physicians to take advantage of these benefits and actively engage in the use of pDAs. 5se of pDAs by the physician, whether it be via the Internet or other media, would facilitate shared decision making by engaging the patient and the physician in a two-way exchange of information, leading to increased patient trust and confidence in the physician. 6In fact, a recent randomized controlled trial showed that patient knowledge was significantly improved when pDAs were administered by the treating physician during the consultation. 7Despite this, nearly all pDAs and decision support tools evaluated to date have been administered by health care professionals other than the treating physician.The needs of our patients are continuously changing, and today, patients have an increasing desire for information and involvement in their health care decisions.As physicians, we need to actively engage in new strategies to meet our patients' needs to communicate effectively and connect with them on a personal level.To accomplish this, researchers need to involve (not avoid) physicians in both the development and implementation of pDAs and decision support tools.
Thyroid Remnant Estimation by Tc-99m-Sestamibi Scanning Predicts the Effectiveness of rhTSH-Stimulated I-131 Ablation in Patients With Differentiated Thyroid Carcinoma
Authors: Luca Giovanella, Sergio Suriano, Massimo Castellani, Luca Ceriani, Frederik A. Verburg
Journal: Clinical Nuclear Medicine (2011)

To evaluate the relationship between postsurgical cervical Tc-99m-sestamibi scan uptake and the rate of successful remnant ablation after recombinant human-thyrotropin (rhTSH)-aided-I-131 ablation in patients with differentiated thyroid carcinoma (DTC).In all, 154 DTC patients who underwent total thyroidectomy and rhTSH-aided remnant ablation with I-131 (3.7 GBq) were enrolled. Tc-99m-sestamibi scans were performed during continuing thyroid hormone administration in all cases. Thyroid ablation was assessed after 6 to 12 months by rhTSH-stimulated I-131-whole-body scan and thyroglobulin measurement. The rate of successful ablation, occurrence of radioiodine-induced thyroiditis, and length of hospitalization were correlated with the Tc-99m-sestamibi scintigraphy results.Tc-99m-sestamibi uptake was significantly lower in ablated versus nonablated patients (P<0.0001). A visually positive scan and a Tc-99m-sestamibi uptake greater than 0.9% predicted a high-risk of unsuccessful ablation, prolonged hospitalization, and the occurrence of radioiodine-induced thyroiditis.Tc-99m-sestamibi scintigraphy is a simple and feasible tool to evaluate thyroid remnants and to predict radioiodine ablation results in patients with DTC.
Polymerase chain reaction for diagnosis of dermatophyte and Scytalidium spp. onychomycosis
Authors: J. Menotti, M. Machouart, M. Benderdouche, C. Cetre-Sossah, P. Morel, L. Dubertret, F. Derouin, M. Feuilhade de Chauvin, C. Lacroix
Journal: British Journal of Dermatology (2004)
Screening for Sickle Cell Hemoglobinopathies
Authors: Roland B. Scott
Journal: JAMA (1979)

Screening for sickle cell hemoglobin can detect carriers, who can benefit from education and genetic counseling, and can bring about early diagnosis, supportive care, and management for patients with established disease. However, such screening programs shoud be designed and supervised properly by health professionals to avoid methodological pitfalls and other unfortunate circumstances that have occurred in the past. (<i>JAMA</i>241:1145-1147, 1979)
SNAKE VENOM IN HEMORRHAGIC STATES
Authors: C. H. WATKINS
Journal: Annals of Internal Medicine (1937)

Editorial1 April 1937SNAKE VENOM IN HEMORRHAGIC STATESC. H. WATKINSC. H. WATKINSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-10-1595 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe value of moccasin venom in the control of hemorrhage was pointed out by Peck and Rosenthal.1Peck had earlier found that moccasin venom would produce a refractory state to experimental purpura, or the Shwartzman phenomenon. For a number of years venom of various snakes has been suggested for innumerable diseases, but more definitely in relation to the production of hemostasis by direct application to the bleeding area. It was not until the work of Peck and Rosenthal with the parenteral use of moccasin venom that definite improvement was obtained in certain so-called secondary hemorrhagic states. The exact action of...1 PECKROSENTHAL SMN: Effect of moccasin snake venom (Ancistrodon Piscivorus) in hemorrhagic conditions, Jr. Am. Med. Assoc., 1935, civ, 1066-1070. PECK, S. M., CRIMMINS, M. L., and ERF, L. A.: Coagulating power of Bothrops Atrox venom on hemophiliac blood, Proc. Soc. Exper. Biol. and Med., 1935, xxxii, 1525- 1527. PECK, S. M., ROSENTHAL, N., and ERF, L. A.: The value of the prognostic venom reaction in thrombocytopenic purpura, Jr. Am. Med. Assoc., 1936, cvi, 1783-1791. CrossrefGoogle Scholar2 MUSSEY RD: Discussion, Proc. Staff Meet. Mayo Clinic, 1936, xi, 263-264. WATKINS, C. H.: Experience with snake venom in menorrhagia, Proc. Staff Meet. Mayo Clinic, 1936, xi, 261-263. WATKINS, C. H., and THOMPSON, G. J.: Results in treatment of essential hematuria with moccasin venom, Proc. Staff Meet. Mayo Clinic. (In press.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEmergencies Arising in the Anemias and Blood Dyscrasias 1 April 1937Volume 10, Issue 10Page: 1595-1596KeywordsHemorrhageHemostasisVenoms ePublished: 1 December 2008 Issue Published: 1 April 1937 PDF downloadLoading ...
Different diastolic regional myocardial motion of pacing-induced left bundle branch block versus idiopathic left bundle branch block with or without left ventricular dysfunction
Authors: Soo-Jin Kang, Jae-Kwan Song, Hyun Suk Yang, Jong-Min Song, Duk-Hyun Kang, Kyoung-Suk Lee, Gi-Byoung Nam, Kee-Joon Choi, Jae-Joong Kim, You-Ho Kim
Journal: Journal of the American College of Cardiology (2003)
AUTOPLASTIC SUTURE IN HERNIA, AND OTHER DIASTASES.—PRELIMINARY REPORT.
Authors: L. L. McARTHUR
Journal: JAMA (1901)

Without entering into a discussion of the relative merits of suture materials possible or desirable, all of which can be found in our text-books, it shall be the aim of this brief and preliminary communication to show the feasibility as well as the desirability in certain situations of utilizing the patient's own living tissues as the resisting medium to future hernia. While at work with an inguinal hernial operation the idea occurred to me that it would be feasible to utilize a strip of the tendinous portion of the external oblique, which, possessing fibers in the adult from 5 to 6½ inches in length, would have sufficient strength to act as a substitute for the absorbable kangaroo sutures. Experiments on dogs and operations on the human being have proven to me the feasibility of the procedure; it remains for the future to determine the actual value of the suggestion.  Mentioning
Altered trafficking of cells during acute pulmonary allergic and viral inflammatory stimuli in rats with the chronic postbronchiolitis asthma-like phenotype
Authors: R.L. Sorkness, L.A. Rosenthal, T. Pier, S.P. Amineva, R.J. Szakaly, R.F. Lemanske
Journal: Journal of Allergy and Clinical Immunology (2005)
Plasma and urinary amino acids in primary gout, with special reference to glutamine
Authors: Ts'Ai-Fan Yü, Max Adler, Elias Bobrow, Alexander B. Gutman
Journal: Journal of Clinical Investigation (1969)

Measurement of the plasma free amino acids by column chromatography (AutoAnalyzer) in 32 patients with primary gout showed statistically significant increases or decreases in several components when compared with the spectrum in 18 control subjects, but the absolute amounts involved were small and the mean total plasma amino acid concentrations in both groups were the same. In the urine all major amino acid components, notably glutamine, serine, threonine, and leucine, were lower in our gouty than in our nongouty subjects, as were also the corresponding renal clearance ratios. These deficits could be reproduced by restricting dietary protein, so appear to be due largely to the some-what reduced mean dietary protein intake of our gouty subjects. However, the low renal clearance of glutamine, the most striking and consistent of the deficits in urinary amino acids noted, could not be accounted for by dietary or other relevant factors, and is interpreted as indicating increased tubular reabsorption of glutamine in primary gout. This interpretation was supported by the results of glutamine loading. The possible compensatory relationship of the abnormality in renal handling of glutamine to the deficiency in renal production of ammonia previously reported is discussed.
Modification of glomerular immune complex deposition in mice by activation of the reticuloendothelial system.
Authors: U Barcelli, R Rademacher, Y M Ooi, B S Ooi
Journal: Journal of Clinical Investigation (1981)

To determine the effect of activation of the reticuloendothelial system on the localization of immune complexes in the kidney, a model of passive serum sickness nephritis in the mouse was used, with activation of the reticuloendothelial system with Corynebacterium parvum. Groups of mice, control and C. parvum-treated animals, were injected with BSA-125I-anti-BSA complexes containing 3 mg 125I-anti-BSA. Blood was obtained at 5 min, at 3 h, and at 12 h, when the animals were killed. Blood concentrations of BSA-125I-anti-BSA complexes were reduced in C. parvum-treated animals compared with controls. This appeared to be mediated by two effects, increased uptake of complexes in the liver and spleen, and enhanced degradation of immune complexes as measured by TCA-soluble radioactivity. In vitro studies using cultures of peritoneal macrophages also showed enhanced uptake of immune complexes. The amount of immune complexes deposited in the glomeruli of C. parvum-treated animals was reduced as determined by quantitation of radiolabeled material bound to isolated gomeruli and by immunofluorescence techniques. The results of the study emphasize the role of the reticuloendothelial system in the modulation of immune complex localization in the kidney and suggest a potential use of stimulants of the reticuloendothelial system in the therapy of immune complex nephritis.
Abnormalities of Ventricular Motion Induced by Atrial Pacing in Coronary Artery Disease
Authors: ANDRE PASTERNAC, RICHARD GORLIN, EDMUND H. SONNENBLICK, JACOB I. HAFT, HARVEY G. KEMP
Journal: Circulation (1972)

In order to study left ventricular performance and motion under ischemic stress, incremental atrial pacing was performed in 10 patients with angiographically proven coronary artery disease until angina pectoris or segmental S-T depression appeared. Single-plane left ventricular cineangiograms were obtained in both the resting and the transiently ischemic state induced by pacing. Abnormal motion appeared with pacing in two of three patients with normal contraction at rest; in one of them, gross dyskinesis of the cardiac apex was noted. Seven patients had abnormal contraction at rest; six showed an increase in either the severity or the topographic distribution of abnormality, while one showed no change. Left ventricular end-diastolic pressure and cardiac index were not altered significantly despite changes in the pattern of contraction. Left ventricular end-diastolic volume decreased irrespective of the development of asynergy, but ejection fraction decreased markedly in those patients in whom asynergy was induced de novo or increased. Thus left ventriculography during pacing-induced ischemia may reveal segmental or generalized abnormalities of contraction not necessarily reflected in the usual hemodynamic parameters of function. Moreover, asynergy induced by pacing is associated with a decreased ejection fraction.
Review: Evidence on PPIs for nonspecific chronic cough in adults with gastroesophageal reflux disease is inconsistent
Authors: Benson T. Massey
Journal: Annals of Internal Medicine (2011)

Source Citation Chang AB, Lasserson TJ, Gaffney J, Connor FL, Garske LA. Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults. Cochrane Database Syst Rev. 2011;(1):CD004823. 21249664
Computed Tomography in Evaluation of Patients With Ovarian Carcinoma in Complete Clinical Remission
Authors: Daniel L. Clarke-Pearson, Lawrence C. Bandy, Michelle Dudzinski, Dennis Heaston, William T. Creasman
Journal: JAMA (1986)

Computed tomography (CT) of the abdomen and pelvis was performed in 47 patients who were in complete clinical remission from ovarian carcinoma. Results of CT were correlated with surgical-pathologic findings at surgical reexploration. Overall, CT had a sensitivity of 0.32, specificity of 0.77, positive predictive value of 0.79, and negative predictive value of 0.30. Accuracy of CT did not vary by intraperitoneal or retroperitoneal site studied. Computed tomography detected only 7% of tumor nodules 1 cm or less in diameter and only 37% of nodules over 1 cm in diameter. The utility of CT in this clinical setting was limited to approximately 20% of patients with true-positive CT findings who might have been saved surgical reexploration. Due to a high false-negative rate, a normal CT cannot replace a second-look laparotomy for accurate assessment of disease status. (<i>JAMA</i>1986;255:627-630)
Chronic Lymphocytic Leukemia or Lymphoma and Carcinoma of the Colon
Authors: George A. Hyman, John E. Ultmann, Charles A. Slanetz
Journal: JAMA (1963)

An apparent increase of blood group antigen A was noted during a study of 21 patients with carcinoma of the colon associated with either leukemia or lymphoma. Thirteen of 20 patients typed were blood type A. This incidence was then compared to that of the blood group A antigen in the normal population of the city of New York, the blood donor group of Columbia-Presbyterian Medical Center, patients with carcinoma of the colon alone, and patients with leukemia and lymphoma alone. Occurrence of blood type A in patients with these two neoplasms was found to be higher than in the normal population and also higher than in the colon carcinoma group. Eighteen of the 21 patients had the lymphocytic form of chronic leukemia or lymphosarcoma.