Ceftriaxone-induced Cholelithiasis
Authors: Alvaro J. Lopez, Paul O'Keefe, Marilynn Morrissey, Jack Pickleman
Journal: Annals of Internal Medicine (1991)

Brief Reports1 November 1991Ceftriaxone-induced CholelithiasisAlvaro J. Lopez, MD, Paul O'Keefe, MD, Marilynn Morrissey, Jack Pickleman, MDAlvaro J. Lopez, MD, Paul O'Keefe, MD, Marilynn Morrissey, Jack Pickleman, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-9-712 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGallbladder sludge formation has been reported as a unique complication of therapy with ceftriaxone. We report the first patient with proven ceftriaxone-induced cholelithiasis in which the drug was identified as the major component of the gallstone.Case ReportA 42-year-old man had a history of rheumatic heart disease and of chronic active hepatitis for which he was receiving prednisone. Between September 1989 and February 1990 he had three episodes of infective endocarditis withSalmonellagroup C1(Salmonella choleraesuis). Each episode of endocarditis was treated with a prolonged (minimum, 7 weeks) course of intravenous ceftriaxone, 2 g every 12 hours, and...References1. SchaadWedgwood-KruckoTschaeppeler UJH. Reversible ceftriaxone-associated biliary pseudolithiasis in children. Lancet. 1988; 2:1411-3. CrossrefMedlineGoogle Scholar2. SchaadTschappelerLentze UHM. Transient formation of precipitations in the gallbladder associated with ceftriaxone therapy. Pediatr Infect Dis. 1986;5:708-10. CrossrefMedlineGoogle Scholar3. MeyboomKuiperJansen RHA. Ceftriaxone and reversible cholelithiasis. BMJ. 1988;297:858. CrossrefMedlineGoogle Scholar4. SchaadSuterGianella-BorradoriPfenningerAuckenthalerBernath USAJRO. A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children. N Engl J Med. 1990;322:141-7. CrossrefMedlineGoogle Scholar5. PigrauPahissaGropperSuredaMartinez-Vazquez CASDJ. Ceftriaxone-associated biliary pseudolithiasis in adults [Letter]. Lancet. 1989;2:165. 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I. ?-Lactam antibiotics and related compoundsAntibiotic-Associated Hepatitis: Update from 1990Transient False-Positive Hepatobiliary Scan Associated With Ceftriaxone TherapyCeftriaxone-associated gallbladder lithiasis in childrenBiliary sludge: Curiosity or culprit?Pathogenesis and Treatment of GallstonesPiperacillin/tazobactam/amikacin versus piperacillin/amikacin/teicoplanin in the empirical treatment of neutropenic patientsGall-bladder sludge: Lessons from ceftriaxone 1 November 1991Volume 115, Issue 9Page: 712-714KeywordsCholelithiasisChronic hepatitisDrugsEndocarditisGallbladderHepatitis AInfectious diseasesInterleukinsSalmonellaSludge Issue Published: 1 November 1991 PDF DownloadLoading ...