tbuckley/cabot-search huggingface dataset:
High IGSF4 expression in pediatric M5 acute myeloid leukemia with t(9;11)(p22;q23)
Authors: Jenny E. Kuipers, Eva A. Coenen, Brian V. Balgobind, Jan Stary, Andre Baruchel, Valerie de Haas, Eveline S. J. M. de Bont, Dirk Reinhardt, Gertjan J. L. Kaspers, Jacqueline Cloos, Astrid A. Danen-van Oorschot, Monique L. den Boer, Rolf Marschalek, Claus Meyer, Rob Pieters, C. Michel Zwaan, Marry M. van den Heuvel-Eibrink
Journal: Blood (2010)
SERUM DIAGNOSIS OF SYPHILIS
Authors: S. S. Hindman
Journal: JAMA (1918)

<h3>To the Editor:</h3> —Referring to the article of Dr. Noguchi (The Journal, April 20, 1918, p. 1157) and his supplementary note (April 27, p. 1252) on the use of sodium acetate in preserving guinea-pig complement for the serum diagnosis of syphilis, I should like to add that while sodium acetate does work very well with many guinea-pig serums, it is not entirely satisfactory with some specimens, owing to a certain amount of precipitation that occurs occasionally. The sharp reactions and rapid hemolysis that tend to take place with complement preserved with the acetate has in my experience during the last six months indicated that in the weaker positive reactions they were more likely to become negative, thereby giving one a misleading result. This so far is the only criticism that I could make regarding the use of sodium acetate for the purpose. I might say that with the ice-box method
Repeats, longevity and the sources of mtDNA deletions: evidence from ‘deletional spectra’
Authors: Xinhong Guo, Konstantin Yu. Popadin, Natalya Markuzon, Yuriy L. Orlov, Yevgenya Kraytsberg, Kim J. Krishnan, Gábor Zsurka, Douglas M. Turnbull, Wolfram S. Kunz, Konstantin Khrapko
Journal: Trends in Genetics (2010)
Alcohol-induced Cushingoid syndrome.
Authors: A G Smalls, P W Kloppenborg, K T Njo, J M Knoben, C M Ruland
Journal: BMJ (1976)

with Hypaque was performed before the expected date of ovulation, and laparoscopy before menstruation.'All but one of the laparoscopies were per- formed under local anaesthesia2 with about 30 ml aqueous methylene blue injected under low pressure into the uterine cavity.On laparoscopy the dye could be seen traversing patent tubes and spilling into the pouch of Douglas.Bilateral tubal patency was shown in 27 patients by hysterosalpingography and 33 by laparoscopy (see table).In 700Z of the patients known to have some degree of tubal occlusion the two methods gave closely similar results, whereas periadnexal adhesions were detected in 57 patients (66 %) by laparoscopy but in only four patients (47 %0) by hysterosalpingography.Laparoscopy also permitted an assessment of the severity of the adhesions and the degree to which other organs were affected.Thirteen patients who appeared to have either bilateral or unilateral patent tubes on their hystero- salpingograms were shown by laparoscopy to have fimbrial phimosis.
Gene expression of tumor necrosis factor [alpha ] and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
Authors: Javier Crespo, Amalía Cayón, Pedro Fernández-Gil, Manuel Hernández-Guerra, Marta Mayorga, Agustín Domínguez-Díez, José Carlos Fernández-Escalante, Fernando Pons-Romero
Journal: Hepatology (2001)

The main objective of this study was to analyze the pathogenic role of the tumor necrosis factor alpha (TNF-alpha) system in the development of nonalcoholic steatohepatitis (NASH). Fifty-two obese patients were studied. We investigated: (1) the expression of mRNA of TNF-alpha and their p55 and p75-receptors by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) in hepatic and adipose tissues; and (2) the relationship between TNF-alpha, p55, and p75 and the severity of NASH. Obese patients without NASH were the control group. A remarkable increase in the expression of mRNA of TNF-alpha was found in patients with NASH in hepatic tissue (0.65 +/- 0.54) and in peripheral fat (0.43 +/- 0.45); in the control samples, the mRNA expression was 0.28 +/- 0.32, P <.007, and 0.26 +/- 0.22, P <.018, respectively. Furthermore, we found a significant increase in the mRNA levels of p55 receptor (2.42 +/- 1.81 vs. 1.56 +/- 1.17; P <.05); however, the mRNA expression of the p75 receptor was similar in both patients. Those patients with NASH with significant fibrosis presented an increase in the expression of mRNA TNF-alpha in comparison with those with a slight or nonexistent fibrosis. An overexpression of TNF-alpha mRNA is found in the liver and in the adipose tissue of NASH patients. The levels of mRNA-p55 are increased in the liver tissue of NASH patients. This overexpression is more elevated in patients with more advanced NASH. These findings suggest that the TNF-alpha system may be involved in the pathogenesis of NASH.
Hepatic and extrahepatic HCV RNA strands in chronic hepatitis C: Different patterns of response to interferon treatment
Authors: Beatriz Gil, Cheng Qian, Jose I. Riezu-Boj, Maria P. Civeira, Jesús Prieto
Journal: Hepatology (1993)

We investigated the presence of positive (genomic) and negative (replicative intermediate) hepatitis C virus RNA strands in liver, peripheral mononuclear cells and serum from patients with chronic hepatitis C using a selective and semiquantitative polymerase chain reaction procedure. Negative and positive hepatitis C virus RNA strands were present in liver, serum and lymphoid cells in all untreated patients and in all those who did not respond to interferon therapy. In the latter group of patients, the titers of RNA strands in the liver and peripheral mononuclear cells at the end of the treatment were similar to those encountered in untreated patients, but the serum titers were about 100 times lower than pretreatment values. In patients who responded to interferon with normalization of serum aminotransferase levels (n = 10), the rate of detection and the titer of the two viral strands in liver, serum and mononuclear cells were markedly decreased at the end of the therapy. In the six responders who did not relapse after interferon withdrawal, both hepatitis C virus RNA strands were absent from the liver, serum and lymphoid cells. By contrast, the positive RNA strand was present in liver cells, mononuclear cells or both at the end of therapy in all patients who experienced posttherapy relapse. In conclusion, our results indicate that interferon can clear hepatitis C virus from hepatic and extrahepatic sites only in responder patients. Disappearance of genomic hepatitis C virus RNA from the liver and from mononuclear cells may predict complete response without posttherapy relapse.
Hemodynamic studies in long- and short-term portal hypertensive rats: The relation to systemic glucagon levels
Authors: Emanuel Sikuler, Roberto J. Groszmann
Journal: Hepatology (1986)

It is not known whether the hyperdynamic state which has been observed in several experimental models and in patients with portal hypertension reflects a temporary phase during the evolution of the portal hypertensive syndrome or is an expression of a permanent steady state. A hemodynamic study was performed in a group of rats with long-standing portal hypertension induced by portal vein constriction performed 6.2 +/- 0.1 months earlier. A group of rats matched by age and weight with short-term (20.7 +/- 0.9 days) portal hypertension and a group of long-term (6.2 +/- 0.1 months) sham-operated rats were used as controls. Cardiac output and regional blood flows were measured using a radioactive microsphere technique. Arterial blood levels of glucagon, a known vasodilator that was implicated in the etiology of the hyperdynamic circulation, were also measured. Portal pressure in long- and short-term portal hypertensive groups (12.3 +/- 0.4 and 13.7 +/- 0.4 mm Hg; not statistically significant) was higher than in the sham group (9.0 +/- 0.3 mm Hg; p less than 0.01). Cardiac output in the long-term portal hypertensive rats was similar to the sham-operated group and lower than in the short-term portal hypertensive group (19.4 +/- 1.0 and 20.6 +/- 1.5 vs. 32.7 +/- 2.0 ml X min-1 X 100 gm body weight-1; p less than 0.01). Portal venous inflow in the long-term portal hypertensive group was also similar to the sham group and lower than in the short-term portal hypertensive group (4.51 +/- 0.36 and 4.58 +/- 0.39 vs. 6.72 +/- 0.48 ml X min-1.(ABSTRACT TRUNCATED AT 250 WORDS)
Cell cycle–dependent uptake of putrescine and its importance in regulating cell cycle phase transition in cultured adult mouse hepatocytes
Authors: Roger L. Martin, Kenneth F. Ilett, Rodney F. Minchin
Journal: Hepatology (1991)

Previous studies in which investigators have induced the rate of polyamine uptake in vitro have used either inhibitors of polyamine biosynthesis or growth factors that induce cell proliferation. Recently, however, we have described the induction of putrescine uptake in cultured adult mouse hepatocytes and have shown that uptake is independent of both intracellular polyamine levels and proliferation. Although proliferation was not apparent in those studies, data suggested that, after isolation, the cells entered G1 of the cell cycle. In this study, we have examined whether the induction of putrescine uptake is a function of entry into the cell cycle and whether uptake activity is essential for optimal progression into the S phase. Using ribonuclease reductase subunit M1 as a marker of entry into the cell cycle, we have shown that hepatocytes enter G1 during the first 4 hr of culture. Both putrescine uptake and ornithine decarboxylase activity increased as the cells entered G1. Treatment of the cells with retinoic acid (10 to 33 mumol/L) prevented them from entering G1 and also inhibited the induction of the putrescine transporter by up to 90%. In contrast, initiation of G1 to S phase transition markedly down-regulated the activity of the transporter. Thus induction of the putrescine transporter in isolated hepatocytes appears to be a G1-specific event. Culturing the hepatocytes in the presence of 1,1'-bis[3-(1'-methyl-[4,4'-bipyridinium]-1-yl)-propyl]- 4,4'-bipyridinium, a potent competitive inhibitor of putrescine uptake, resulted in a 47% decrease in intracellular putrescine.(ABSTRACT TRUNCATED AT 250 WORDS)
Atlas of Bladder Disease
Authors: Navin C. Shah
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence for Use of Coronary Stents: A Hierarchical Bayesian Meta-Analysis
Authors: James M. Brophy, Patrick Belisle, Lawrence Joseph
Journal: Annals of Internal Medicine (2003)

Background: Coronary stents are widely used in interventional cardiology, but a current quantitative systematic overview comparing routine coronary stenting with standard percutaneous transluminal coronary angioplasty (PTCA) and restricted stenting (provisional stenting) has not been published. Purpose: To summarize results from all randomized clinical trials comparing routine coronary stenting with standard PTCA. Data Sources: Electronic databases were searched by using the key words angioplasty and stent. References from identified articles were also reviewed. In addition, several prominent general medical and cardiology journals were searched and agencies known to perform systematic reviews were consulted. Study Selection: All comparative randomized clinical trials were included, except those involving primary angioplasty for the treatment of acute myocardial infarction. Data Extraction: A specified protocol was followed, and two of the authors independently extracted the data. Outcomes assessed were total mortality, myocardial infarction, angiographic restenosis, coronary artery bypass surgery, repeated PTCA, and freedom from angina. Data Synthesis: The results were synthesized by using a Bayesian hierarchical random-effects model. A total of 29 trials involving 9918 patients were identified. There was no evidence for a difference between routine coronary stenting and standard PTCA in terms of deaths or myocardial infarctions (odds ratio, 0.90 [95% credible interval (CrI], 0.72 to 1.11]) or the need for coronary artery bypass surgery (odds ratio, 1.01 [CrI, 0.79 to 1.31]). Coronary stenting reduced the rate of restenosis (odds ratio, 0.52 [CrI, 0.37 to 0.69]) and the need for repeated PTCA (odds ratio, 0.59 [CrI, 0.50 to 0.68]). The trials showed a wide range of crossover rates from PTCA to stenting. By use of a multiplicative model, each 10% increase in crossover rate decreased the need for repeated angioplasty by approximately 8% (odds ratio multiplying factor, 1.08 [CrI, 0.98 to 1.18]). Routine stenting probably reduces the need for repeated angioplasty by fewer than 4 to 5 per 100 treated persons compared with PTCA with provisional stenting. Studies were not blinded and suggest a bias with a possible overestimation of this benefit. Conclusions: In the controlled environment of randomized clinical trials, routine coronary stenting is safe but probably not associated with important reductions in rates of mortality, acute myocardial infarction, or coronary artery bypass surgery compared with standard PTCA with provisional stenting. Coronary stenting is associated with substantial reductions in angiographic restenosis rates and the subsequent need for repeated PTCA, although this benefit may be overestimated because of trial designs. The incremental benefit of routine stenting for reducing repeated angioplasty diminishes as the crossover rate of stenting with conventional PTCA increases.
Detection of <i>Chlorella</i>‐specific IgE in mould‐sensitized children
Authors: E. Tiberg, W. Rolfsen, R. Einarsson, S. Dreborg
Journal: Allergy (1990)

The content of IgE, specific to the unicellular green alga Chlorella sp., was analysed in sera from 46 atopic children sensitized to moulds, using radioallergosorbent test (RAST), immunoblotting and crossed immunoelectrophoresis/crossed radioimmunoelectrophoresis (CIE/CRIE). Chlorella ‐specific IgE was found in 23/46 sera by RAST, in 28/41 sera by immunoblotting and in 6/30 sera by CIE/CRIE. The Chlorella components most frequently binding IgE as analysed by gradient gel electrophoresis and immunoblotting were of molecular weights of approximately 13, 17, 19, 26 and 49 kD. Twenty‐nine precipitating antigens, including seven IgE‐binding precipitates were detected by CIE/CRIE. The study shows that low concentrations of specific IgE are formed to the green alga Chlorella in sera from atopic individuals sensitized to moulds.
Activity of the Akt/GSK-3β pathway in the failing human heart before and after left ventricular assist device support
Authors: P Razeghi
Journal: Cardiovascular Research (2003)

The authors measured the activity of several kinases that are involved in the regulation of hypertrophy and apoptosis in the failing human heart before and after mechanical unloading with a left ventricular assist device (LVAD) [1].They found that the activity of Erks and Akt in the failing human heart decreased after LVAD support, while that of glycogen synthase kinase-3h (GSK-3h) increased.These changes
Stands by Dr. Cohen.
Authors: S. Goodman
Journal: JAMA (1894)

Boston, March 26, 1894. <h3>To the Editor:</h3> —I can not conceive how you permitted the publication of the contemptible, narrow and insulting letter signed " Medicus." He may well stay in the background by keeping his name away from the public—cowardice is depicted in every line. I am inclined to think that "Medicus" has ill feelings against Prof. Solomon Cohen for reasons known to himself—he was probably plucked by Dr. Cohen for deficiency in the subject that Dr. Cohen lectures on? I will not attempt to discuss the " advertising question," for you have requested the matter to end. The publication of the vile letter has, and will excite bitter criticism. It is unnecessary for me to speak in defense of Dr. Cohen and the Hebrew race. Hoping you will find space to publish this brief note, so that " Medicus" can see what repute he has gained by making a ferocious
Activation of Renal Cortical Adenylate Cyclase by Circulating Immunoreactive Parathyroid Hormone Fragments
Authors: Janet M. Canterbury, Gerald S. Levey, Eric Reiss
Journal: Journal of Clinical Investigation (1973)

Three distinct immunoreactive species of parathyroid hormone (PTH) are present in human serum. One has an estimated mol wt of 9,500 and probably represents glandular hormone, the second 7,000-7,500 mol wt, and the third 4,500-5,000 mol wt. In order to assess the biological activity of these circulating forms of PTH, we determined their ability to activate renal cortical adenylate cyclase. The 9,500 mol wt and 4,500-5,000 mol wt fractions produced four- to sixfold increases in cyclic 3′,5′-AMP accumulation above control; the 7,000-7,500 mol wt fraction was inactive. None of the fragments had any effects on phosphodiesterase activity. Antiserum to bovine PTH did not block the activation of adenylate cyclase by either the gragments or bovine PTH. The data suggest that a large proportion of circulating immunoreactive human PTH is biologically active and that the biologically and immunologically active sites of the hormone are distinct.
A1.39 Modulation of atp:adenosine balance by exosome and rain (Recombinant Anti-Inflammatory Fusion Protein) delivery of CD39 and CD73 is effective in reducing pro-inflammatory cytokine and chemokine production
Authors: Jonathan D Finn, Susanne Snoek, Jan van Ittersum, Niels Broekstra, Carola Feijt, Paul P Tak, Margriet J Vervoordeldonk
Journal: Annals of the Rheumatic Diseases (2014)

The initial event upon binding of insulin-like growth factor 1 to the insulin-like growth factor type-I receptor (IGF-1R) is auto-phosphorylation of tyrosine residues within the activation loop of the kinase domain followed by phosphorylation of other receptor tyrosine residues and the subsequent activation of the intracellular signaling cascades. We found recently that the cyclolignan picropodophyllin (PPP) inhibits phosphorylation of IGF-1R and phosphatidyl-3 kinase/Akt (protein kinase B) signaling molecules without interfering with the highly homologous insulin receptor. Furthermore, PPP causes regression of tumor grafts and substantially prolongs the survival of animals with systemic tumor disease. It is of interest that we show here that short treatments with PPP activate the intracellular extracellular signal-regulated kinase (ERK) signaling. Our data suggest that PPP induces IGF-1R ubiquitination and in turn activates ERK1/2. The PPP-induced ERK activation requires IGF-1R because PPP is not able to induce ERK phosphorylation in IGF-1R-negative cells or in cells in which the receptor is knocked down by small interfering RNA. Moreover, in the absence of Mdm2, an E3 ligase that has been shown previously to be involved in IGF-1R ubiquitination, the phosphorylation of ERK did not occur. Thus, apart from inhibiting the receptor activity, PPP can induce IGF-1R ubiquitination and stimulate ERK in an Mdm2-dependent manner. This response could contribute to the apoptotic effect of PPP.
Ventricular Origin of Bidirectional Tachycardia
Authors: JOHN A. KASTOR, BRUCE N. GOLDREYER
Journal: Circulation (1973)

Electrophysiological, hemodynamic and angiographic studies were performed on an 18 year old woman with asymptomatic recurrent bidirectional tachycardia of eight years' duration and mild hyperkalemic periodic paralysis. Multiple surface electrocardiograms and His bundle and right atrial electrograms revealed that 1) all beats during bidirectional tachycardia originated in the left ventricle; 2) the two forms of ventricular beats in the bidirectional tachycardia had qR patterns in lead V 1 (suggesting left ventricular origin) and axes in the frontal plane of –75° and +110°; 3) the interectopic interval of the two forms of QRS in bidirectional tachycardia was relatively fixed at 440-470 msec; 4) the runs of bidirectional tachycardia always terminated with the beat with right axis deviation; 5) fusion between sinus beats and one of the two forms of ventricular beats produced multiform complexes observed on the electrocardiogram; 6) the sinus beats showed T wave abnormalities and their A-H and H-V intervals were normal. Lidocaine and atrial pacing at an interval of 500 msec each separately suppressed the arrhythmia. Administration of potassium chloride to a blood level 5.4 mEq/liter and of procainamide did not affect the arrhythmia. Hemodynamic, left ventricular and coronary angiographic studies were normal. Bidirectional tachycardia in this case originated in the left ventricle and was unassociated with digitalis intoxication or demonstrable nonelectrical cardiac pathology.
1144 SINGLE CENTER EXPERIENCE OF 313 PATIENTS WITH DRUG INDUCED LIVER INJURY: CAUSES, OUTCOME, PROGNOSIS AND RISK FACTORS FOR MORTALITY
Authors: H. Devarbhavi, R. Dierkhsing, W. Kremers, M. Sandeep, D. Karanth, C. Adarsh, M. Mujaddid, A.J.J. Chazhikattu
Journal: Journal of Hepatology (2010)
Stiffness of the Great Toe Joint in Male Adolescents
Authors: H. Marsh
Journal: BMJ (1887)

Argyll Robertson's operation on the Tight eye.After six days, the sutures were removed, but the lead was forgotten in the conjunctival sac for nine days longer.CASE VI.-On August 6th, 1885, Dr. Story did a similar operation on the same patient's left eye ; the sutures were removed after four days.Portions of both eyelids were noted as being in " fairly good position" some time after the operations; but, owing to the great thickening of the conj unctiva, a perfect result was not to be expected.CASES vii and viii.-RobertG., aged 50 (No. 319),was admitted August 19th, 1885.Argyll Robertson's operation was done on each side by Dr. Story.The result was " not satisfactory," though there was some improvement.The lead, after the operation, was very liable to slip out of its place, and so it got hardly a fair chance.CASE ix.-On October 3rd, 1885, the operation was repeated on the left eye.It was followed by considerable swelling of the lid and pain, so that the suture had to be removed after three days.It was then found that the lid had sloughed through its whole thickness from the pressure of the india-rubber tubing.When the raw surfaces be- came healthy, their edges were pared, and brought together with sutures-thus making a modified Adams's operation of it, with quite
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Authors: Mark F. van Delft, Andrew H. Wei, Kylie D. Mason, Cassandra J. Vandenberg, Lin Chen, Peter E. Czabotar, Simon N. Willis, Clare L. Scott, Catherine L. Day, Suzanne Cory, Jerry M. Adams, Andrew W. Roberts, David C.S. Huang
Journal: Cancer Cell (2006)