tbuckley/cabot-search huggingface dataset:
Oxidants, nitric oxide and prostanoids in the developing ocular vasculature: a basis for ischemic retinopathy
Authors: P Hardy
Journal: Cardiovascular Research (2000)

The choroid is the main source of oxygen to the retina. In contrast to the adult, the absence of autoregulation of choroidal blood flow in the newborn leads to hyperoxygenation of the retina. In the immature retina which contains relatively low levels of antioxidants this hyperoxygenation favors peroxidation including the generation of biologically active isoprostanes, and results in vasoconstriction and vascular cytotoxicity leading to ischemia, which predisposes to the development of a vasoproliferative retinopathy, commonly termed retinopathy of prematurity. During frequently encountered oxidative stress to the perinate, the combined absence of vascular autoregulation and excessive oxygen delivery to the eyes of the developing subject is largely the result of a complex epigenetic and genetic interplay between prostanoids and nitric oxide (NO) systems on vasomotor regulation. The effects of certain prostaglandins are NO-dependent; conversely, those of NO have also been found to be largely prostaglandin I2-mediated in the eye; and NO synthase expression seems to be significantly regulated by other prostaglandins apparently through activation of functional perinuclear prostanoid receptors which affect gene transcription. The increased production of both prostaglandins and NO in the perinate augment ocular blood flow and as a result oxygen delivery to an immature retina partly devoid of antioxidant defenses. The ensuing peroxidation results in impaired circulation (partly thromboxane A2-dependent) and vascular integrity, leading to ischemia which predisposes to abnormal preretinal neovascularization, a major feature of ischemic retinopathy. Because tissue oxygenation is largely dependent upon circulation and critical in the generation of reactive oxygen species, and since the latter exert a major contribution in the pathogenesis of retinopathy of prematurity, it is important to understand the mechanisms that govern ocular blood flow. In this review we focus on the important and complex interaction between prostanoid, NO and peroxidation products on circulatory control of the immature retina.
Abstract 672: TumoraseTM: <i>In vivo</i> efficacy data for novel localized proteinase treatment applicable to solid tumors of varied tissue origins
Authors: Yong Qian, John A. Drewe, Jin Shi, Michael McClurg, Weidong Li, Thomas N. Campbell
Journal: Cancer Research (2010)

Abstract To facilitate the development of noninvasive solid tumor cancer treatments, BioMedicure reports here the development of a specific proteinase treatment that when injected locally into solid tumors elicits a substantial tumor remission. Reported here is data indicating that intratumoral injection of TumoraseTM (T101, BioMedicure, San Diego, CA), a novel proteinase formulation, into solid tumors of various tissue origin destroys the tumor by digesting the solid-structure, killing cancer cells, including cancer stem cells, locally while not effecting normal tissues. The best route of TumoraseTM biochemical delivery to the tumor is intratumoral injection by a needle with a gauge 20-27. Before TumoraseTM intratumoral delivery, the tumor volume is estimated by 3-dimensional measurement and calculation: L x W X H in mm3, where “L” is the solid-tumor length, “W” solid-tumor width and “H” solid-tumor height. Tumorase works best when intratumorally injected at about 50-80% of solid-tumor volume delivered not by bolus but at about 200 uL per minute. The success rate of eliminating sparsely vascularized solid-tumors 50-400 mm3 in volume is high (over 70%). However, since inhibitory factors in serum diminish the activity of TumoraseTM, the success rate of eliminating a highly vascularized soft or liquid tumor is low (below 30%), though partial tumor mass decrease responses are observed. Multiple treatments can be applied to further diminish tumor mass. Data will be presented for the following tumor models, the human melanoma (CRL-1676 and WM-266-4), the human prostates (CRl-2505 and 22Rv1), human breast ductal carcinomas (HTB-129 and MDA-MB-435S), the human bronchioalveolar carcinomas (HTB-177 and NCI-H460) and the human colon adenocarcinomas (CCL-231 and SW48) xenografts. When a cancerous growth is found early and is accessible by a surgical knife, surgery is still the recommended treatment. However, if not accessible or there are multiple tumors, then, TumoraseTM would be a viable option, a local therapy that can be utilized for multiple tumors elimination. TumoraseTM contains proteases that cleave the extracellular matrix, including vital proteins required for cell survival, leading to cancer cell death. Presented here is in vivo data indicating the efficacy of this novel proteinase preparation for the elimination of solid tumors of multiple tumor classes by destroying tumors’ solid structure and killing cancer cells by cleaving the extracellular domains of vital cell membrane proteins. The wide range of solid cancerous tumors eliminated suggests a potential wide clinical applicability. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 672.
3D Fusion of LV Venous Anatomy on Fluoroscopy Venograms With Epicardial Surface on SPECT Myocardial Perfusion Images for Guiding CRT LV Lead Placement
Authors: Weihua Zhou, Xiaofeng Hou, Marina Piccinelli, Xiangyang Tang, Lijun Tang, Kejiang Cao, Ernest V. Garcia, Jiangang Zou, Ji Chen
Journal: JACC. Cardiovascular imaging (2014)
Serum osteocalcin concentrations in patients with rheumatoid arthritis.
Authors: D Vanderschueren
Journal: Annals of the Rheumatic Diseases (1990)

Letters to the editor patients.Cryoglobulinaemia was not suspected in our patients in the absence of suggestive clinical phenomena and therefore cryoglobulins were not assayed.Further study of such patients may clarify the relevance of the finding of mixed cryoglobulinaemia to the pathogenesis of the arthropathy.The importance of serial serological testing of several streptococcal antibodies is emphasised.
Paediatric Neurology in Africa: A Ugandan Report
Authors: H. G. Egdell, J. P. Stanfield
Journal: BMJ (1972)

The findings in 138 children attending a neurology clinic in Uganda are presented. In contrast with findings in developed countries, only 25 had an abnormal birth and history dating from birth compared with 63 who had a normal birth and early development with symptoms of <i>postnatal</i> onset. The commonest mode of onset in the postnatal period was a catastrophic, feverish illness. Effective and usually easily achieved drug control of epilepsy and hyperkinesis enabled most parents to cope with disabled children. Simple explanation to parents and teachers can reduce the rejection and educational retardation associated with epilepsy. Primary prevention lies in earlier diagnosis and treatment of cerebral malaria, meningitis, and encephalitis and improved obstetric services. Secondary prevention requires closer follow-up of potentially brain-damaged children and the education of doctors in neurological and behavioural assessment and the more efficient treatment of epilepsy and hyperkinesis.
Web Resources for Pharmacogenomics
Authors: Guoqing Zhang, Yunsheng Zhang, Yunchao Ling, Jia Jia
Journal: Genomics Proteomics & Bioinformatics (2015)

Abstract Pharmacogenomics is the study of the impact of genetic variations or genotypes of individuals on their drug response or drug metabolism. Compared to traditional genomics research, pharmacogenomic research is more closely related to clinical practice. Pharmacogenomic discoveries may effectively assist clinicians and healthcare providers in determining the right drugs and proper dose for each patient, which can help avoid side effects or adverse reactions, and improve the drug therapy. Currently, pharmacogenomic approaches have proven their utility when it comes to the use of cardiovascular drugs, antineoplastic drugs, aromatase inhibitors, and agents used for infectious diseases. The rapid innovation in sequencing technology and genome-wide association studies has led to the development of numerous data resources and dramatically changed the landscape of pharmacogenomic research. Here we describe some of these web resources along with their names, web links, main contents, and our ratings.
Porokeratosis of Mibelli: successful treatment with 5% imiquimod cream
Authors: S. Agarwal, J. Berth-Jones
Journal: British Journal of Dermatology (2002)

Journal Article Porokeratosis of Mibelli: successful treatment with 5% imiquimod cream Get access S. Agarwal, S. Agarwal Department of Dermatology, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K Search for other works by this author on: Oxford Academic Google Scholar J. Berth‐Jones J. Berth‐Jones Department of Dermatology, George Eliot Hospital NHS Trust, Nuneaton, Warwickshire CV10 7DJ, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 2, 1 February 2002, Pages 338–339, https://doi.org/10.1046/j.1365-2133.2002.4653_8.x Published: 01 February 2002
Unusual presentations of tuberculosis
Authors: B. T. Le Roux
Journal: Thorax (1971)

The author, the chief investment officer at Arizona State Retirement System, shares perspectives and lessons learned from 4 decades of experience in private markets investing. <b>TOPIC:</b>Manager selection <b>Key Findings</b> • Private markets investing is business investing, and you need to focus on the quality of the business approach in creating a strategic advantage in the markets served. • Private markets investing is a hiring decision, and you need to assess the quality of the organization under consideration for a strategy. Management should be expected to demonstrate an ability not just to remain healthy but to grow and improve through the tenure of your relationship with them. • Managing cost of fees is important, but not sufficient to ensure success. Alignment of interest across a range of outcomes, not just the upside, should be given paramount importance in partnership structuring.
Colon Cancer Biomarker
Authors: Joan Stephenson
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 39-1968
Authors: Cecil H. Coggins, Martin H. Flax
Journal: New England Journal of Medicine (1968)

Presentation of CaseA fifty-three-year-old woman was admitted to the hospital because of vomiting and weakness.Two months previously she entered another hospital because of frequent vomiting of bilious material of two weeks' duration. Cholecystographic examination showed a nonfunctioning gallbladder, and cholecystectomy with a common-duct exploration was performed. After discharge she continued to vomit repeatedly, and her weight decreased from 240 to 190 pounds. There was no discoloration of the skin or urine. Four days before admission she noticed weakness of the legs, and a few days later she was unable to raise herself from a chair.There had been . . .
First reviews are published that are based on the "totality of the evidence"
Authors: Z. Kmietowicz
Journal: BMJ (2013)

Scientists and medical publishers have heralded “a historic moment for open science” after a medical device company gave researchers unprecedented access to all the data they had on one of their products for independent evaluation.

The reviews were done by two independent teams using the same data. They both found that recombinant human bone morphogenetic protein 2 (rhBMP-2), an orthobiological agent used in some surgeries to promote bone growth, shows little benefit in spinal fusion compared with iliac crest bone graft or other bone grafts, and that it may cause more harms.

The findings are published in the Annals of Internal Medicine and are based on patient level data from clinical trials conducted by Medtronic, which were shared with researchers through the Yale University open data access (YODA) project.1 2

The data are now being made available to others who want to examine them to answer further scientific questions.

In an …
Treatment of Multiple Rectal Carcinoids by Endoscopic Mucosal Resection Using a Device for Esophageal Variceal Ligation
Authors: Y. Okamoto, M. Fujii, S. Tateiwa, T. Sakai, F. Ochi, M. Sugano, K. Oshiro, K. Masai, Y. Okabayashi
Journal: Endoscopy (2004)

A 54-year-old man was referred to our hospital because of lower abdominal discomfort. Total colonoscopic examination was performed and four protruding yellow-white lesions, 6 mm or less in diameter, were detected in the rectum (Figure [1] a). At endoscopy it was suspected that these lesions were rectal carcinoids and this diagnosis was confirmed by histological examination of biopsy specimens. Endoscopic ultrasonography demonstrated that the carcinoid tumors were localized within the submucosal layer (Figure [1] b). Abdominal ultrasonography and computed tomography did not show any evidence of abdominal lymph node swelling or of metastatic lesions in the liver.
MONOCULAR DIPLOPIA.Read in the Section on Ophthalmology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.
Authors: T. H. THOMPSON
Journal: JAMA (1891)

vertical and least frequently in the oblique diam¬ eters, of the cornea.As a rule the annoyances were greatest when the faulty corneal curvatures were obliquely placed.The 0.25 C. gave the re¬ lief sought, in by far the majority• of these cases.In many of these persons whose history could be traced, perfect relief continued with the use of these weak cylinders.I have formulated for myself in office work this order.When a young person with no eye congestion who has f$ vision and reads readilyNo. 1 of the test types, complains of pain in eyes aud head on use, so convinced am I that astigma¬ tism is at the bottom of the trouble that I seek it at once ,in the very beginning of the eye exam¬ ination.If it had not been found by others it is not because it did not exist, but because it had not been diligently sought.That a great many of these patients would exhibit heterophoria from the fixed standard of muscular strength, I am quite convinced.I find in by far the major¬ ity of cases with the correction of the astigma¬ tism all evidence of muscle straining passes off, and in such patients the heterophoria does not call for recognition, because it no longer annoys when the cylinders are worn.The least degrees of astigmatism cause in the world the greatest amount of head and eye dis¬ comfort, and the 0.25 C. will correct these re¬ fractive errors and will relieve head and eye pains.I not only therefore say that the weak cylinder ought to be prescribed, but that the ophthalmic surgeon is remiss who does not seek, find, and correct these small but annoying errors in cor¬ neal curvature.DISCUSSION.Dr. J. L. Thompson spoke of a case in which 0.25 D. gave relief when 0.50 D. did not.Dr. F. C Hotz said he often finds cases of a low degree where cylinders do not relieve the asthenopia.In these cases the asthenopiais due to heterophonia.Dr. T. E. Murrell called attention to an un¬ accountable condition frequently observed by him, viz.: two eyes having an equal degree of astig¬ matism but with very unlike vision uncorrected, one being sometimes doubly as acute as the other, but both having equal vision with the same correcting glass.
Recertification: A Status Report
Authors: WALTER B. FROMMEYER
Journal: Annals of Internal Medicine (1973)

As President of the American College of Physicians, it is my responsibility to keep the membership of the College informed about the status of recertification in the broad field of internal medicine. For the past several years the Board of Regents of the American College of Physicians has given this matter its careful attention. After the adoption of a policy on recertification by the American Board of Internal Medicine (ABIM) in 1969 and the appointment of a committee on recertification by the ABIM, the Board of Regents in 1970 appointed an ad hoc liaison committee to work closely with the
Crystal Structure of I-Ak in Complex with a Dominant Epitope of Lysozyme
Authors: Daved H. Fremont, Didier Monnaie, Christopher A. Nelson, Wayne A. Hendrickson, Emil R. Unanue
Journal: Immunity (1998)

We have determined the structure of murine MHC class II I-Ak in complex with a naturally processed peptide from hen egg lysozyme (HEL residues 50–62) at 1.9 Å resolution. These results provide a structural basis for the I-Ak peptide-binding motif. Binding is established by the deep burial of five anchor side chains into specific pockets of the I-Ak binding groove, with a zen-like fit of an aspartic acid in the P1 pocket. We also show that in the I-Ak α chain, a bulge occurs in the first strand of the peptide-binding platform, an insertion probably common to all I-A and HLA-DQ alleles. The I-Ak β chain has a deletion in the helical region adjacent to the P7 pocket and an insertion in the helical region neighboring the P1 pocket. As a result of these structural features, the extended HEL peptide dips low into the center of the I-Ak groove and reaches toward solvent at its C-terminal end.
Ischemic and non-ischemic acute kidney injury cause hepatic damage
Authors: Fereshteh Golab, Mehri Kadkhodaee, Maryam Zahmatkesh, Mehdi Hedayati, Hossein Arab, Rebecca Schuster, Kamyar Zahedi, Alex B. Lentsch, Manoocher Soleimani
Journal: Kidney International (2009)
A Simple Electrocardiographic Indication of Left Atrial Enlargement
Authors: Aida C. Arevalo
Journal: JAMA (1963)

The P-waves in standard electrocardiograms were analyzed in 101 normal children and adolescents and in 88 with asymptomatic rheumatic heart disease. Results were correlated with roentgenographically significant left atrial enlargement defined by new criteria that increase precision in x-ray assessment. Abnormalities in P-waves were more consistent in lead V-1 than in lead II. Left atrial enlargement could be suspected when a broadly-notched P<sub>II</sub>or an inverted or diphasic P<sub>V-1</sub>was seen, and confirmed if the P-wave downstroke in V-1 was more than 1.0 mm deep or lasted more than 0.06 sec, or if P<sub>II</sub>lasted more than 0.12 sec. P-waves were abnormal in lead V-1 for 29, and in lead II for 8, of 35 patients with significant left atrial enlargement. Normal and abnormal P-waves often overlapped in the analysis of lead II, but were sharply differentiated in lead V-1.
Surfactant Protein C Mutations Are the Basis of a Significant Portion of Adult Familial Pulmonary Fibrosis in a Dutch Cohort
Authors: Coline H. M. van Moorsel, Matthijs F. M. van Oosterhout, Nicole P. Barlo, Pim A. de Jong, Joanne J. van der Vis, Henk J. T. Ruven, H. Wouter van Es, Jules M. M. van den Bosch, Jan C. Grutters
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Familial clustering of adult idiopathic interstitial pneumonias (IIP) suggests that genetic factors might play an important role in disease development. Mutations in the gene encoding surfactant protein C (SFTPC) have been found in children and families with idiopathic pneumonias, whereas cocarriage of a mutation in ATP-binding cassette subfamily A member 3 (ABCA3) was postulated to have a disease-modifying effect.To investigate the contribution of SFTPC mutations to adult familial pulmonary fibrosis (FPF) and the disease-modifying effect of mutations in ABCA3 within their families.Twenty-two unrelated patients with FPF (10%) were identified within our single-center cohort of 229 patients with IIP. SFTPC was sequenced in 20 patients with FPF and 20 patients with sporadic IIP. In patients with an SFTPC mutation, sequencing of ABCA3 was performed. Discovered variants were typed in more than 100 control subjects and 121 additional patients with sporadic IIP.In 5/20 unrelated patients with FPF (25%; confidence interval, 10-49) a mutation in SFTPC was detected: M71V, IVS4+2, and three times I73T. No mutations were detected in the sporadic or control cohort. Patients with SFTPC mutations presented with a histopathological pattern of usual interstitial pneumonia and nodular septa thickening and multiple lung cysts in combination with ground glass or diffuse lung involvement on chest high-resolution computed tomography. Two variants in ABCA3 were found in adult patients with FPF but not in affected children.Mutations in SFTPC are a frequent cause of FPF in adult patients in our cohort. Nonclassifiable radiological patterns with cystic changes and histopathological patterns of usual interstitial pneumonia are characteristics of adult SFTPC mutation carriers.
Testing their metal.
Authors: B E Fisher
Journal: Environmental Health Perspectives (1999)

Metals continually rank at the top of the U.S. Environmental Protection Agency's annual list of agents that pose the greatest hazard to the people of the United States. Metals aren't going away, either. They do not biodegrade, and they often concentrate in human and animal cells and tissue. Many metals are known human and animal carcinogens, while many others are suspected to play a role in cancer. Little is known, however, about the mechanisms by which metals cause cancer.