tbuckley/cabot-search huggingface dataset:
Mobile Physiotherapy Unit
Authors: G. A. Powell-Tuck
Journal: BMJ (1954)

Sir,?Much time and unnecessary expense is entailed by patients who have to attend hospitals on many occasions for physiotherapy. The large majority of these are of middle or advanced age, and they have to attend hospital in the most treacherous time of the year, when they are exposed to chill and its subsequent complications. Mobile units do exist in some areas at the expense of the local authority. Would it not be possible to extend these amenities ??I am, etc.,
The reduction of tumor interstitial fluid pressure by liposomal imatinib and its effect on combination therapy with liposomal doxorubicin
Authors: Yuchen Fan, Wenwen Du, Bing He, Fengying Fu, Lan Yuan, Hounan Wu, Wenbing Dai, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang
Journal: Biomaterials (2013)
Changing the Treatment Paradigm for Acute Otitis Media in Children
Authors: Michael E. Pichichero
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Runaway children: whose problem?
Authors: F Lawrenson
Journal: BMJ (1997)

hould the BMJ reject all studies that do not include informed consent?That's a simple question, and surely the answer should be equally simple-"Yes."Unfortunately, ethical questions rarely allow simple answers, and we want help with answering this one.This issue includes a cluster of material that relates to the question.We publish the materialincluding two studies in which informed consent was not sought-to encourage debate and to arrive at a deeper understanding if not a simple answer.Medical journals must consider the ethical aspects of all the material they publish, and medical editors are presented with ethical issues just as often as doctors-that is, every day.
Evidence-based mechanistic reasoning
Authors: Jeremy Howick, Paul Glasziou, Jeffrey K Aronson
Journal: Journal of the Royal Society of Medicine (2010)

Systematic reviews of high quality randomized trials generally count as the ‘best evidence’. However, well-conducted randomized trials are sometimes unavailable, unfeasible, unethical or unnecessary. In such cases other forms of evidence must be considered. Many EBM proponents accept mechanistic reasoning (‘pathophysiologic rationale’) for generalizability, hypothesis generation, ruling out implausible hypotheses, and for supporting efficacy in the absence of other ‘stronger’ forms of evidence. Yet because mechanistic reasoning has often led us astray, most EBM proponents are justifiably sceptical about using mechanistic reasoning as evidence for efficacy. We suggest that the scepticism about the value of mechanistic reasoning should not extend to high quality mechanistic reasoning. Just as poor quality randomized trials (that are unblinded, underpowered or biased, that employ unconcealed allocation, or otherwise biased) will not provide high quality evidence for efficacy, so poor quality mechanistic reasoning will be unreliable. In this theoretical exploration we suggest that mechanistic reasoning involving a not incomplete inferential chain and that takes potential complexity into account can and should be used as evidence of efficacy. We support our rules for mechanistic evidence with three examples.
Safety of Ipecac Syrup
Authors: William O. Robertson
Journal: JAMA (1980)

<h3>To the Editor.—</h3> On behalf of the American Association of Poison Control Centers, I am concerned about the titling of a recent<i>JAMA</i>article, "Death Resulting From Ipecac Syrup Poisoning" (243:1927, 1980). I am worried that the index skimmer or scanner—particularly if he is of the older school reared in an era of gastric lavage for management of poisonings—may inadvertently conclude that the typical emetic dose of syrup of ipecac was responsible. In reality, the dose was three to four bottles per day for three months—thus representing a long-term poisoning. As noted by the authors, syrup of ipecac as an emetic agent has a remarkable safety record; its current availability over-the-counter and in the home permits an enormous saving of needless visits to emergency rooms for the treatment of accidental ingestions. I think that it would be unfortunate indeed were the inference drawn that single emetic doses were risky.
The Real Meaning of Rationing
Authors: David O. Meltzer, Allan S. Detsky
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergenic diversity of the olive pollen
Authors: R. Rodríguez, M. Villalba, E. Batanero, E. M. González, R. I. Monsalve, S. Huecas, M. L. Tejera, A. Ledesma
Journal: Allergy (2002)

A great number of allergenic proteins have been detected in olive pollen extracts. To date, nine allergens have been isolated and characterized, which have been called Ole e 1 to Ole e 9. The most prevalent olive allergen is Ole e 1, which affects more than 70% of patients hypersensitive to olive pollen, but others, such as Ole e 2, Ole e 8, and Ole e 9, have been demonstrated to be major allergens, and Ole e 6 or Ole e 7 reach high values of clinical incidence. Many of these allergens, such as Ole e 2 (profilin) and Ole e 3 (polcalcin), are involved in cross‐reactivities, which agrees with their adscription to panallergenic families. Among the many olive allergens of high molecular mass, only Ole e 9 (46 kDa) has been characterized. The allergen is a polymorphic and glycosylated β‐1,3‐glucanase, which belongs to a pathogenesis‐related (PR‐2) protein family. In addition to the polypeptide epitopes, Ole e 1 also exhibits IgE‐binding determinants in the carbohydrate, which are recognized by more than 60% of the sera from patients sensitive to the whole allergen, although the level of such glycan‐specific IgE seems not to be clinically relevant in the overall content of the sera. Recent advances in the elucidation of the structure of the Ole e 1‐oligosaccharide component allows us to explain the antigenicity of the molecule. Finally, the recombinant production of several allergens from olive pollen in both bacterial and eukaryotic cells has allowed us to resolve problems derived from the polymorphism and scarcity of the natural forms of these allergens. The biological equivalence between the natural and recombinant forms lets us initiate studies on the design of mixtures for clinical purposes, in which hypoallergenic derivatives of these allergens could play a definitive role.
135. Replication Competent Ad11 Vectors Possess a High Potential for Human Cells Targeted Cancer Therapy
Authors: Ya-Fang Mei, Goran Wadell
Journal: Molecular Therapy (2006)

Human adenovirus serotype 11 belongs to species B:2 adenoviruses and causes persistent kidney infection in human. It has been reported that Ad11 binds two receptors: sBAR and sB2AR i.e. CD46. Our previous results indicated that Ad11 can internalize and induce expression in many human cells. The complete genome of Ad11 has been sequenced by us. We have now constructed a replication competent Ad11 vector system composed of three different constructs: Ad11, Ad11e1GFP, Ad11e3GFP vectors. Either linear or circular DNA of Ad11 vectors was transfected into A549 cells and formed virus particles after 4 to 7 days post transfection.
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
Authors: Guangwu Guo, Xiaojuan Sun, Chao Chen, Song Wu, Peide Huang, Zesong Li, Michael Dean, Yi Huang, Wenlong Jia, Quan Zhou, Aifa Tang, Zuoquan Yang, Xianxin Li, Pengfei Song, Xiaokun Zhao, Rui Ye, Shiqiang Zhang, Zhao Lin, Mingfu Qi, Shengqing Wan, Liangfu Xie, Fan Fan, Michael L Nickerson, Xiangjun Zou, Xueda Hu, Li Xing, Zhaojie Lv, Hongbin Mei, Shengjie Gao, Chaozhao Liang, Zhibo Gao, Jingxiao Lu, Yuan Yu, Chunxiao Liu, Lin Li, Xiaodong Fang, Zhimao Jiang, Jie Yang, Cailing Li, Xin Zhao, Jing Chen, Fang Zhang, Yongqi Lai, Zheguang Lin, Fangjian Zhou, Hao Chen, Hsiao Chang Chan, Shirley Tsang, Dan Theodorescu, Yingrui Li, Xiuqing Zhang, Jian Wang, Huanming Yang, Yaoting Gui, Jun Wang, Zhiming Cai
Journal: Nature Genetics (2013)
The long shadow of cerebral localization
Authors: S. Shafqat
Journal: Journal of the Royal Society of Medicine (2005)

In 1995, during my first week as a neurology resident at Massachusetts General Hospital, I had the privilege of meeting the late Raymond Adams.He was an established octogenarian by then, but the years had made no difference to his air of professionalism and academic authority.His reputation was made in the 1950s and 1960s, when he developed Boston as a major centre of clinical neurology.Among other things, he is immortalized through a famous textbook that has appeared in multiple editions.Our meeting took place at a clinical conference in which I was required to present a case.He was a demanding clinician, and my neurological examination did not meet his standards of thoroughness.Despite my best efforts, I could not remove the look of displeasure from his face.I defended myself, invoking time efficiency and what not, but Dr Adams was unforgiving.'You can't rush a neurological examination,' he said.'A proper one takes three days.'Dr Adams was, of course, echoing a mindset that goes back to the very foundations of neurology.In 1875, Jean-Martin Charcot had delivered a series of lectures to the Paris Medical School on cerebral localization, laying out a method that sought clinical alliance between pathological cerebral lesions and clinical signs in living patients.He was already much more than a professor by then, his profile and personality was compared to Napoleon and Caesar.He was also well into a legendary career at the Salpe ˆtrie `re Hospital that would enshrine him as the father of neurology.The method of cerebral lesion localization became the founding pillar of neurology as a clinical discipline.It is a powerful diagnostic tool that permits reasonably accurate spatial localization of a lesion within the nervous system without resort to technology.The benefits are obvious.The problem, unfortunately, is that lesion localization became an end in itself.
SOME UNCOMMON OR SINGULAR CASES.Read before the Pennsylvania State Medical Society, May, 1894.
Authors: JOHN M. BATTEN
Journal: JAMA (1894)

<i>Dysmenorrhea, Catalepsy, Hysteria</i>.—In 1867 a female, single, age 18 years, of nervous temperament, came under my observation and treatment for a period of three years. There were dysmenorrhea with scanty and irregular discharge, tenderness over spine, hyperesthesia over surface of body, and great tenderness over the region of her genital organs. There developed during the early part of this period, many strange and unusual symptoms and she exhibited many remarkable freaks. One day she would have a jumping toothache, the next day she would be hysterically insane, almost uncontrollable, the following day she would be in a profound catalepsy, the day after she would be a songster and the following day she might be rational. Another day she would suffer colicky pains in the abdomen, followed by all sorts of contortions of the body. These conditions would repeat themselves, period after period, in various forms. In the evening of her
The tightly regulated inducible expression of the core protein of hepatitis C virus modulates Fas- and TNF alpha-mediated apoptosis in human liver cells
Authors: Rodolfo Sacco, Ryosuke Suzuki, Hideki Aizaki, Takeya Tsutsumi, Motoyuki Otsuka, Mami Matsuda, Naohiko Seki, Yoshiharu Matsuura, Tetsuro Suzuki, Tatsuo Miyamura
Journal: Journal of Hepatology (2002)
Intermittent brief periods of ischemia have a cumulative effect and may cause myocardial necrosis.
Authors: I L Geft, M C Fishbein, K Ninomiya, J Hashida, E Chaux, J Yano, J Y-Rit, T Genov, W Shell, W Ganz
Journal: Circulation (1982)

We investigated the effects of brief intermittent periods of ischemia on myocardial viability. Brief periodic coronary occlusions were produced up to 18 times by inflating and deflating the balloon of an intracoronary No. 2F catheter for periods of 15, 10 or 5 minutes, followed by 15-minute periods of reperfusion. Creatine kinase (CK) release, triphenyl tetrazolium chloride staining, and light and electron microscopy were used to detect the presence of myocardial necrosis. For the study of CK release, blood was taken from the great cardiac vein and the aorta before and at 5-minute intervals during each left anterior descending coronary occlusion, as well as during and 1, 5, 10 and 15 minutes after balloon deflation. In seven of 24 dogs with 15-minute occlusions, in five of 21 dogs with 10-minute occlusions, and in three of 32 dogs with 5-minute occlusions, small but distinct areas of subendocardial necrosis were present. In all dogs with morphologic proof of necrosis, there was periodic release of CK into the great cardiac vein, which peaked immediately after reperfusion, reflecting CK washout. Thus, brief periods of ischemia, which when single do not cause necrosis, have a cumulative effect and may cause myocardial necrosis. This mechanism of necrosis may be relevant clinically in patients with frequent anginal episodes. Since many dogs of this study did not have any myocardial necrosis, the findings also suggest that intermittent reperfusion has a beneficial effect and may prevent necrosis, even when total occlusion time exceeds 200 minutes.
Prostatic Acid Phosphatase by Radioimmunoassay
Authors: George R. Lindholm
Journal: JAMA (1980)

Prostatic acid phosphatase values in 98 patients with prostatic carcinoma were measured by a commercial radioimmunoassay (RIA) and by enzymatic assay. Forty-three carcinomas were staged by rigorous pathological criteria. Patients (N = 129) with benign prostatic hyperplasia were the control group. At 94% specificity, sensitivities of the RIA vs the enzymatic assay for clinically staged patients were as follows: stage A, 22% vs 6%; B, 29% vs 10%; C, 52% vs 38%; and D, 87% vs 80%. However, none of the seven patients with pathological stage A and B disease had a positive test result, and we suggest that variability in staging criteria accounts for the discrepant sensitivity claims reported. Prostatic acid phosphatase RIA should not be used for screening but as an adjunct for staging known prostatic carcinoma.
Vitamin D Receptor Gene Polymorphism in Patients with Sarcoidosis
Authors: TAKASHI NIIMI, HIROSHI TOMITA, SHIGEKI SATO, HARUHIKO KAWAGUCHI, KENJI AKITA, HIROYOSHI MAEDA, YOSHIKI SUGIURA, RYUZO UEDA
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

The active form of vitamin D, 1,25-dihydroxyvitamin D3, is known to be produced at sites of granulomatous reactions in sarcoidosis. 1,25-dihydroxyvitamin D3 has multiple immunomodulatory effects, and acts as a promoter of multinucleated giant cell formation. Polymorphism of the vitamin D receptor (VDR) gene has recently been shown to be related to bone mineral density, and also associated with hyperparathyroidism and risk of prostatic carcinoma. Considering that this might affect sarcoidosis, we investigated polymorphism of the VDR gene in 101 patients with sarcoidosis and 105 healthy control subjects. Their genotypes were determined using polymerase chain reaction (PCR) and restriction fragment length polymorphism. In the patients with sarcoidosis, the BB, Bb, and bb genotypes accounted for 1.0%, 37.6%, and 61.4%, whereas in healthy control subjects the figures were 1.0%, 20.0%, and 79.0%, respectively. The difference in the genotype distribution between healthy control subjects and sarcoidosis patients was significant (p < 0.05) with the frequency of the B allele being elevated (p < 0.05). From the result, we suggest that in VDR gene polymorphism the B allele might be a genetic risk factor for sarcoidosis.
104 IFN/Riba treatment for recurrent hepatitis C after liver transplantation: Progression of hepatic fibrosis is favourably affected in both virological and biochemical sustained responders
Authors: L.S. Belli, A.B. Alberti, A. Airoldi, M. Vangeli, M. Vinci, A. Tringali, O.A. Slim, L. de Carlis, G.B. Pinzello
Journal: Journal of Hepatology (2004)
Correlation of Intrinsic Chemoresistance of Non-Small-Cell Lung Cancer Cell Lines With HER-2/neu Gene Expression but Not With ras Gene Mutations
Authors: C.-M. Tsai, K.-T. Chang, R.-P. Perng, T. Mitsudomi, M.-H. Chen, C. Kadoyama, A. F. Gazdar
Journal: JNCI Journal of the National Cancer Institute (1993)

Background : At diagnosis, most small-cell lung cancers (SCLCs) are chemosensitive, whereas non-small-cell lung cancers (NSCLCs) are usually chemoresistant. Activation of ras genes and HER-2/neu genes (also known as ERBB2) is encountered in subpopulations of NSCLC but not in SCLC and has been linked to shortened survival. Therefore, activation of these genes may be associated with intrinsic chemoresistance in NSCLC. Studies have also suggested that the multidrug-resistant phenotype expressed by the MDR1 gene (also known as PGY1) does not correlate with the in vitro chemosensitivity of NSCLC cells or with clinical response to therapy and does not explain the spectrum of cross-resistance to drugs. Purpose : The purpose of this study was to investigate the relationships between chemoresistance and the presence of ras gene point mutations and overexpression of the HER-2/neu gene in NSCLC cell lines, which indicates gene activation. Methods : Using a panel of 20 NSCLC cell lines established from untreated patients, we assessed the differences in HER-2/neu messenger RNA (mRNA) expression in the cell lines with or without ras mutations. We performed in vitro drug sensitivity testing by the tetrazolium-based MTT [i.e., 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide] assay with doxorubicin, carmustine, cisplatin, melphalan, mitomycin, and etoposide, and we determined the differences in IC 50 values (i.e., the drug concentrations required to inhibit cell growth by 50%) for the cell lines. Results : We found a statistically significant correlation between the IC 50 values for all six drugs and the degree of HER-2/neu gene expression in all 20 cell lines (r = .67-.86; P<.005) as well as in the subpopulation of eight cell lines with ras mutations (r = .83-.98; P<.05). The IC 50 values for doxorubicin, carmustine, cisplatin, and melphalan were not significantly different in the cell lines with or without ras mutations, but the values for mitomycin and etoposide in lines with ras mutations were slightly lower than in those without ras mutations (borderline significance, P =.031). Levels of HER-2/neu expression in cell lines with ras mutations were lower than those without ras mutations, but the difference was not statistically significant Conclusion : Our findings indicate that overexpression of HER-2/neu is a marker for intrinsic multidrug resistance in NSCLC cell lines. Implications : If the clinical relevance of our findings is confirmed, HER-2/neu gene expression can be used as a predictor of therapeutic failure in NSCLCs. The relationships between HER-2/neu gene expression, cell proliferation, and chemoresistance in NSCLC require further investigation. [J Natl Cancer Inst 85: 897–901, 1993]
Anatomic Guide for the Electromyographer: The Limbs
Authors: Raghavaiah Kanakamedala
Journal: JAMA (1982)

This book is an upgraded edition of the one published in 1975. As stated in the foreword and in the introduction by the authors, the manual is based on repeated and "systematic anatomical study of cadaver material, normal subjects, patients and standard anatomy texts and manuals." The book is primarily intended for the electromyographer who performs needle EMG. The material is divided into nine sections on muscles of the shoulder, arm, forearm and hand, foot, leg, thigh, pelvis, and hip. Important muscles in each area are individually illustrated. Their innervation, origin, insertion, points of electrode insertion, and test maneuvers are briefly described. Pitfalls in electrode placement, relevant comments on innervation, and clinical significance of EMG results in pathological situations are also included. The strengths of the book are its brevity, clarity, and overall accuracy. It is a simple, practical anatomic guide to EMG of the limbs and deserves to be
Patients must be told of unintended injuries during treatment
Authors: P. C Hebert
Journal: BMJ (1999)

EDITOR—Hingorani et al state that doctors are not legally obliged to provide patients with an explanation after an adverse event.1 This may be so in the United Kingdom but is not so in Canada. For example, the case of Stamos v Davies concerned a physician who, in attempting a lung biopsy, hit the patient's spleen.2 When asked by the patient …
NATIONAL ASSOCIATION FOR THE STUDY AND PREVENTION OF TUBERCULOSIS
Authors: Homer Folks
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal