tbuckley/cabot-search huggingface dataset:
An October Day
Authors: M. Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE COMPARISON BETWEEN CARDIAC ALLOGRAFT VASCULOPATHY AND ATHEROSCLEROSIS DETECTED BY NEAR-INFRARED SPECTROSCOPY
Authors: Bo Zheng, Akiko Maehara, Gary Mintz, Tamim Nazif, Yarden Wachsman, Luz Jaquez, Leroy Rabbani, Mark Apfelbaum, Ziad Ali, Kate Dalton, Donna Mancini, Giora Weisz
Journal: Journal of the American College of Cardiology (2014)
T-cell reactivity for a peanut-derived epitope in the skin of a young infant with atopic dermatitis☆☆☆★★★
Authors: Frank van Reijsen, Abraham Felius, Erik A.K. Wauters, Carla A.F.M. Bruijnzeel-Koomen, Stef J. Koppelman
Journal: Journal of Allergy and Clinical Immunology (1998)
Cell membrane defects in mental illness
Authors: Beverly Merz
Journal: JAMA (1982)

The cell membrane, rather than the chromosomes, may be the place to look for biological markers of bipolar depressive disease (commonly known as manic-depressive illness), according to research conducted at the University of Texas Health Science Center at Dallas (UTHSCD) and at Northwestern University Medical School in Chicago. Both studies, though unrelated, have detected functional abnormalities in cell membranes that distinguish—with a high degree of accuracy—cells of patients with bipolar depression from those of other persons sampled. The UTHSCD team, directed by neurologist Jay Pettegrew, MD, reported 100% success in distinguishing the cells of 20 persons with previously diagnosed bipolar depression from those of 20 normal persons. Pettegrew describes the investigation, which he conducted with John Nichols, PhD, Nancy Minshaw, MD, John Rush, MD, and Malcolm Stewart, MD, in the<i>Journal of Affective Disorders</i>(in press). In the study, intact living lymphocytes, RBCs, and fibroblasts were analyzed within an hour
Non-fundholding in Nottingham: a vision of the future
Authors: D G Black, A D Birchall, I M G Trimble
Journal: BMJ (1994)

The 1991 health service reforms introduced the internal market and grave individual fundholding practices budgets with which they could attempt to secure preferential access to secondary health care for their patients. In the view of many doctors this undermined the principle of equity on which the NHS was founded. In Nottingham 200 non-fundholding general practitioners have joined together to act in liaison with their purchasing health authority. A committed representative group of general practitioners can collectively offer more time and knowledge to the contracting process while minimising the impact on clinical workload. As a large purchaser with low management costs the group has secured access to quality secondary care which is equitably available to all patients, preventing the development of a local two tier service. Nottingham's non-fundholding model of commissioning is equitable and efficient.
QL-03 * CHOROID PLEXUS TUMORS: THE CLEVELAND CLINIC EXPERIENCE
Authors: M. Bahar, E. Murphy, T. Tekautz, J. Wolff
Journal: Neuro-Oncology (2014)

BACKGROUND: Choroid plexus tumors (CPT) are rare neoplasms divided into Choroid Plexus Papilloma (CPP), Atypical Choroid Plexus Papilloma (APP) and Choroid Plexus Carcinoma (CPC). Due to limited clinical data, many pediatric single cases have been described and more are necessary to complete the picture, particularly in populations that are not age limited. Here we reviewed the Cleveland Clinic experience -adult and pediatric. METHODS: A retrospective analysis of the course of therapy and clinical outcome was assessed in all patients with CPT seen in Cleveland Clinic form 1990 to 2014. RESULTS: We found 11 patients with CPT. The median age at presentation was 18.5 years (range 8 months to 51 years) 6 females, 5 males. The most common presenting symptom was raised intracranial pressure (5 cases) followed by seizures, CN VI palsy, vertigo, diplopia, poor feeding and weight loss (one patient each). The tumors were predominantly observed in the lateral ventricle (4 cases), fourth ventricle (4 cases), posterior fossa (1 case) and unknown location (2 cases). Gross total surgical resection was achieved in 100% of CPT. Complications were minimal, including post-operative residual weakness, gait instability or visual changes. The histology was CPP in nine patients, two of whom developed recurrence requiring repeat resection and adjuvant therapy. Event free survival (EFS) for CPP patients was 12 years. The CPC patients required adjuvant therapy. One CPC patient developed spinal drop metastasis and received craniospinal radiation and gamma knife stereotactic radiosurgery. EFS of our CPC patients was 4.3 years. All patients had great performance status (Average Lansky: 88, Karnofsky: 86). CONCLUSION: The age distribution in our population differed from most other clinical series, suggesting that the tumors may be more frequent in adult patients than originally thought. Our data confirms that gross total resection provides the best prognosis for patients with Choroid Plexus Tumors.
THE COMPARATIVE SUSCEPTIBILITY OF FETAL AND POSTNATAL GUINEA PIGS TO THE VIRUS OF EPIDEMIC INFLUENZA
Authors: Herman A. Dettwiler, N. Paul Hudson, Oram C. Woolpert
Journal: The Journal of Experimental Medicine (1940)

Experiments were carried out to determine the relative susceptibility of guinea pigs at different ages to the virus of epidemic influenza. From a correlation of these studies on the mature fetus, the newborn, and the adult animal, with previously reported findings on the immature fetus, we draw two conclusions: first, that there is a gradually increasing resistance to infection with this virus during intrauterine development, with but little change thereafter; and second, that at the time of birth there is a sudden loss of infectibility by routes other than the intranasal. These results illustrate then the benefits which may accrue if one projects into the period of antenatal life studies dealing with the age factor in relation to susceptibility to infection. It is implied that data collected from observations of the postnatal animal alone are of necessity incomplete and may be misleading.
Factor VII deficiency
Authors: Margaret V. Ragni, Jessica H. Lewis, Joel A. Spero, Ute Hasiba
Journal: American Journal of Hematology (1981)

Abstract This report describes three patients with factor (F) VII deficiency: two adult siblings and an unrelated 5½‐month‐old child who succumbed after several central nervous system (CNS) hemorrhages. This event prompted a review of the literature concerning the incidence and characteristics of intracranial hemorrhage in congenital F VII deficiency. Of 138 patients reported to have F VII deficiency, only 75 were considered to have a true deficiency. There was a 1:1 sex distribution with a 19% incidence of consanguinity in the 63 families which these 75 patients represented. CNS hemorrhage occurred in 12 of the 75 proven factor‐deficient patients – an incidence of 16.0%. There was a 1.4:1 female predominance in this group, with a 44.4% incidence of consanguinity in their nine families. Except for one patient with hypertension, there was no history of preceding trauma or previous underlying CNS abnormality, though head trauma with a difficult vaginal delivery may have occurred in five infants. Diagnostic lumbar puncture or ventricular tap revealed bloody, xanthochromic cerebrospinal fluid in five. Five patients with F VII deficiency developed a CNS hemorrhage prior to 1 week of age, and none survived. Seven patients older than 1 week of age suffered such an event, and four of these survived. It is concluded that the greatest risk factor for development of CNS hemorrhage is trauma related to the birth process.
Platelet‐derived growth factor in asthma
Authors: P. Chanez, M. Vignola, R. Stenger, P. Vic, F.B. Michel, J. Bousquet
Journal: Allergy (1995)

Platelet‐derived growth factor (PDGF) controls cellular growth, migration, and differentiation. It is secreted by various cell types, including macrophages, and participates in tissue repair and epithelial regeneration. PDGF may therefore be involved in airway remodeling in asthma. This study compared the immunoreactivity of PDGF and its receptors (Rα and Rβ) in bronchial biopsies and the levels of PDGF in bronchoalveolar lavage (BAL) fluid of asthmatics and control subjects. Bronchial biopsies were done in a subsegmental bronchus of 11 asthmatics and 11 control subjects by flexible bronchoscope. PDGF AA and BB, and PDGF receptors Rα and Rβ were studied with monoclonal antibodies and revealed by immunoperoxidase staining. The percentage of subjects presenting positive staining with PDGFs and its receptors was studied in the epithelium and submucosa. PDGF AA, AB, and BB were measured in BAL fluid of 18 asthmatics and 10 controls by specific ELISA. In biopsies, there was no significant difference between asthmatics and controls for PDGF AA, BB, PDGF‐Rα and R4bT (Fisher's exact test and Bonferroni's correction). Moreover, the levels of PDGF, AA, AB, and BB were similar in asthmatics and controls. This study does not support a role for PDGF in the repair processes of asthma.
A rare pulmonary zygomycosis manifested as chronic mediastinitis and bronchial perforation
Authors: H-C. Liu, M-S. Jan, Y-C. Lin, W-L. Lin, T-C. Wu, C-N. Huang, C-M. Chen, M-C. Lu
Journal: European Respiratory Journal (2011)

To the Editors:

Zygomycosis is an emerging infection caused by fungi of class Zygomycetes, order Mucorales. It occurs mostly in diabetic and immunocompromised patients, but occasionally occurs in immunocompetent individuals [1]. After rhinocerebral zygomycosis, pulmonary zygomycosis, which carries a high mortality rate, is the second most common presentation [1]. Common manifestations of pulmonary zygomycosis mainly include different types of pulmonary infiltrates [2], and other rare manifestations such as endobronchial mass lesions or mediastinitis. However, in the literature, bronchial perforation caused by zygomycetes has not been previously documented. This report presents the case of a diabetic patient infected with Rhizopus sp., which resulted in chronic mediastinitis and bronchial perforation.

A 76-yr-old, Chinese, never-smoking female with uncontrolled type 2 diabetes experienced a productive cough for 6 months prior to admission. This patient denied having fever, breathlessness, night sweating or body weight loss. Physical examination revealed a moderately nourished female without respiratory distress or fever. Upon admission, laboratory studies revealed a haemoglobin level of 10.5 g·dL−1, white blood cell count 5.4×103 cells per μL (53.3% neutrophils, 28.3% lymphocytes, 6% monocytes and 12% eosinophils), platelet count 355×103 cells per μL, creatinine 0.9 mg·dL−1, C-reactive protein 1.7 mg·dL−1, fasting glucose level 311 mg·dL−1 and glycated haemoglobin 14.7%. The chest radiograph on admission revealed partial atelectasis of the …
<i>Lancet</i> criticises its owner for hosting international arms fair
Authors: Owen Dyer
Journal: BMJ (2005)

The Lancet has criticised its owner and publisher, Reed Elsevier, for involvement in the global arms trade. Reed Elsevier owns the company Spearhead Exhibitions, which this week hosted the defence systems and equipment international (DSEi) exhibition, one of the largest military exhibitions in the world, in London.
Rhinovirus A and C Wheezing Illness in Infancy and the Development of Asthma
Authors: Amaziah Coleman, Kristine Grindle, Tressa Pappas, Fue Vang, Daniel J. Jackson, Michael D. Evans, Ronald E. Gangnon, Robert F. Lemanske, James E. Gern
Journal: Journal of Allergy and Clinical Immunology (2015)
Extramedullary Hematopoiesis Associated with β-Thalassemia
Authors: Edward Smitaman, Ami N Rubinowitz
Journal: New England Journal of Medicine (2010)

A 47-year-old woman of Italian descent with a history of transfusion-dependent β-thalassemia intermedia presented to the emergency department with dyspnea that had worsened during the previous several days. The physical examination revealed 28 respirations per minute, a heart rate of 113 beats per minute, normal oxygenation while the patient was receiving supplemental oxygen, clear lungs, and jugular venous distention. Laboratory analyses showed a hemoglobin level of 4 g per deciliter and a hematocrit of 15%. Chest radiography (Panel A, arrow) and computed tomography (Panel B, arrow) show enlarged central pulmonary arteries owing to pulmonary arterial hypertension. In patients with thalassemia, . . .
Abstract 5136: Sulfiredoxin promotes cell migration through direct interaction with non muscle myosin IIa
Authors: Robert Bowers, Danyelle M. Townsend, Yefim Manevich, Kenneth D. Tew
Journal: Cancer Research (2010)

Abstract Redox homeostasis is frequently dysregulated in cancer cells. In particular, glutathione pathways can be imbalanced and impact cell proliferation and death pathways. S-glutathionylation is the addition of glutathione to basic cysteine residues in certain proteins producing significant changes in their structure/function. Because this post-translational modification is dynamic and reversible, the S-glutathionylation cycle can provide the framework for important cell signaling events in cancer cells. We have shown that sulfiredoxin (Srx) plays a role in deglutathionylation and interacts with proteins such as the phosphatase PTP1B, actin and peroxiredoxin 6 (Prdx 6). Redox regulation of actin modulates cell adhesion and focal contacts. In the present study, we examined the role of Srx in cell migration, invasion and potentially metastasis. Srx was over-expressed by transfection in lung cancer cells (A549). Phalloidin staining showed that Srx over-expression (A549-Srx) led to phenotypic changes in cell adhesion through altered focal adhesion contact points and the cells were more refractory to trypsin release. Relative to wild type, A549-Srx cells showed enhanced migration and invasion in the scratch- and Boyden chamber assays. Proteomic analysis through mass spectrometry demonstrated that Srx interacts with non-muscle myosin IIa (NMIIa) in A549 cells. Reciprocal co-immunoprecipitation of Srx and NMIIa validated this interaction under non-stressed conditions. Either through protein: protein interaction or through redox regulation (or both), Srx appears to be an important mediator of the cell motility and invasive properties of the A549 human lung cancer cell line. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5136.
Discontinuing Anticoagulant Therapy in Surgical Patients With Cardiac Valve Prostheses
Authors: John H. Tinker
Journal: JAMA (1978)

Between 1962 and 1975, a total of 159 patients with previously implanted man-made cardiac valve prostheses underwent 180 subsequent noncardiac operations at Mayo Clinic. All of these patients were receiving anticoagulants. The overall incidence of their documentable thromboembolic complications was approximately 10%. None of the postoperative complications occurred while the patient was in hospital, with the earliest such complication seen two years later. Patients receiving anticoagulants on a long-term basis did, however, have a 13% incidence of various difficulties with hemostasis during and following the later operations. We conclude that there is minimal risk to patients with cardiac valve prostheses who are receiving anticoagulants when the drug regimen is stopped for one to three days preoperatively and one to seven days postoperatively.
The new understanding of two-sided role of glutathione S-transferase M1 in breast cancer susceptibility.
Authors: K Yu, G Di, J Wu, Z Shao
Journal: Cancer Research (2009)

Abstract Abstract #3098 [Background and purpose] Although glutathione S-transferase M1 (GSTM1) enzyme occupies a key position in biological detoxification processes by catalyzing the glutathione conjugation of carcinogens, GSTM1 gene is genetically deleted (referred as GSTM1-null or GSTM1-/-) in a high percentage of the Eurasian populations. Numerous studies have examined the association of GSTM1-/- with breast cancer yielding inconsistent results. In addition, few genetic variants in this gene have been explored. We set out to systematically evaluate the contributions of GSTM1 gene deletion/presence and common variants in GSTM1 to breast cancer, followed by functional studies.&amp;#x2028; [Methods and Results] In the present study, we show that GSTM1-/- does confer a weak increased risk of breast cancer compared with GSTM1-present genotype, being confirmed by a meta-analysis of combining 40 related studies with the current case-control study (921 cases vs. 711 controls) of Chinese population (overall odds ratio of 1.10, 95% confidence interval: 1.04-1.15, P&amp;lt;0.001). Unexpectedly, GSTM1 homozygous wild-type (+/+) is also associated with a risk of breast cancer compared with heterozygous (+/-) individuals on the basis of accurate classification using long-PCR-based assay. Furthermore, for the population with one allele of GSTM1 (GSTM1+/-) accounting for 30-50%, we genotype four common single nucleotide polymorphisms (SNPs) spanning GSTM1 gene and identify a functional variant g.-498C&amp;gt;G in the putative promoter region associated with breast cancer risk. It displays that minor -498G allele is significantly more frequent in breast cancer controls than in cases (odds ratio of 0.51, 95% confidence interval: 0.30-0.86, P=0.012). This allele also leads to significantly reduced promoter activity compared to the major -498C allele. Further studies reveal the -498G can modify AP-2 binding site and decrease GSTM1 transcription. Among the three AP-2 isoforms, AP-2α provides the predominant regulation effect on this SNP.&amp;#x2028; [Conclusions] These results indicate that the effect of GSTM1 genotypes conferring to breast cancer susceptibility is not dosage-dependent as taken for grant previously. GSTM1 has a two-sided role in breast cancer susceptibility; too high or too low expression of GSTM1 is not beneficial. We recommend that the complicated genetic predisposition of GSTM1 be considered when predicting breast cancer susceptibility using single or a panel of genetic variants. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3098.
Psychotherapist-Patient Sexual Contact After Termination of Treatment
Authors: LAURA S. BROWN, DEBRA S. BORYS, ANNETTE M. BRODSKY, NANETTE K. GARTRELL, JACQUELINE C. BOUHOUTSOS, VIRGINA M.T. DAVIDSON, SHIRLEY FELDMAN-SUMMERS, GLEN O. GABBARD, JUDITH L. HERMAN, SILVIA OLARTE, KENNETH S. POPE, MELBA J.T. VASQUEZ, RINA Z. FOLMAN, JOSEPH G. GEORGE, HANNAH LERMAN, PETER OLSSON, JANET L. SONNE
Journal: American Journal of Psychiatry (1992)
Functional thrombomodulin expression on epithelial skin tumours as a differentiation marker for suprabasal keratinocytes
Authors: H. MlZUTANI, S. OHYANAGI, T. HAYASHI, R. W. GROVES, K. SUZUKI, M. SHIMIZU
Journal: British Journal of Dermatology (1996)

In normal human skin, immtmoreactive thrombomodulin (TM) is expressed in a strict differentiation related pattern. solely in suprabasal spinous layer keratinocytes. To evaluate the polential application of TM as a differentiation marker for keratinocyte‐derived skin tumours, we have studied immunohistopathological, biochemical and functional TM activities in various skin tumours. Immunoreactive, full sized and enzymatically active TM was expressed in keratinocyte‐derived skin tumours (squamous cell carcinoma, seborrhoeic keratosis and partly Bowen's disease), as well as normal epidermal keratinoeytes and endothelial cells. However, no TM was detected in basal cell carcinotnas, senile keratosis or non‐squanious epithelial tumours such as malignant melanoma, naevus pigmentosus and Paget's disease. Interestingly, decreased expression was observed in verruca vulgaris. These findings suggested that differentiation‐dependent TM expression was restricted to epithelial skin tumours and undetectable on neural crest derived tumours. TM is a differentiation marker for spinous layer keratinocytes and is a useful tool in histopathological study of epithelial tumours.
Abstract P2-10-04: The Mammostrat Test is an Effective Tool to Stratify Patient Samples Previously Characterized as Intermediate by the Oncotype Dx Test
Authors: KJ Bloom, A Kyshtoobayeva, L Hilaire, K Gutekunst
Journal: Cancer Research (2012)

Abstract Mammostrat is a well validated, 5-antibody immunohistochemistry (IHC) based assay initially developed to assess the risk of recurrence in patients with early stage estrogen receptor (ER) positive breast cancer. Recent data from the TEAM trial demonstrated that Mammostrat predicted distant relapse free survival (DRFS) for both exemestane and tamoxifen-exemestane treated patients irrespective of nodal status and chemotherapy. OncoType Dx® is a recurrence assay frequently used by oncologists to aid in the selection of early stage breast cancer patients who may benefit from adjuvant chemotherapy. It is currently unclear whether patients whose tumors demonstrate an intermediate risk score should receive chemotherapy. We sought to determine if tumors with intermediate OncoType Dx® scores would be clearly classified as high or low risk with the Mammostrat assay. Formalin fixed paraffin embedded tissue blocks were retrieved from 143 patients whose tumor were previously assessed as intermediate with the OncoType Dx® assay (Genomic Health, Redwood City, Ca). Six serial 5 micron sections were cut from the tissue block. One section was stained with H&amp;E and the remaining five sections were stained with the Mammostrat antibodies, NDRG1 (AGI-3-3-12E clone, Clarient, Aliso Viejo, CA), TRMT2A (AGI-2-33-12E clone, Clarient, Aliso Viejo, Ca), P53 (D07 clone, Dako, Carpenteria, CA), CEACAM (S0235 08/28/06 clone, Clarient, Aliso Viejo, CA)and SLC7A5 (AGI-1-108-2E clone, Clarient, Aliso Viejo, CA). Slides were reviewed by a single pathologist (KJB) using previously published Mammostrat criteria and a risk score of low, moderate or high was generated. Of the 143 tumors, 62 (43%) were classified as low risk, 51 (36%) were classified as high risk and 30 (21%) were classified as moderate risk. Thus, 113 (79%) cases were defined as either low risk or high risk by the Mammostrat assay. The Mammostrat assay reclassified 79% of OncoType Dx® intermediate tumors into a clear high risk or low risk category. Based on data from the TEAM trial, node negative patients categorized as low risk by Mammostrat had a 5 year DRFS of 96%, while data from the NSABP-B20 trial showed that patients categorized as high risk by the Mammostrat assay derived a significant benefit from adjuvant chemotherapy. Mammostrat may be an effective tool to aid oncologists and patients in treatment decisions when Oncotype Dx® classifies a tumor as intermediate risk. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-10-04.