tbuckley/cabot-search huggingface dataset:
Silicosis and Other Pneumoconioses in Sweden
Authors: O. A. Sander
Journal: JAMA (1961)

This recent book by 3 outstanding authorities on the pneumoconioses and beautifully translated into English, represents a thorough and detailed summation of the silicosis morbidity and mortality in Sweden in the 25-year interval from 1931 to 1956. To this has been added the Swedish experience with other pneumoconioses, such as asbestosis, talcosis, siderosis, and so forth. The material for this study was obtained from cases which were reported to insurance companies for compensation for disability due to these occupational lung diseases. In many individual cases the authors were permitted to make new and complete examinations and chest roentgenograms for comparison with earlier records and films. In this way, they are able to show the frequency, severity, and tendency to progression of the various pneumoconioses. One of the most impressive features of this book is the section of reproductions of the chest roentgenograms of some of the patients referred to in
Simplified Bedside Thoracentesis
Authors: Bert Govig
Journal: Annals of Internal Medicine (1994)

Letters15 April 1994Simplified Bedside ThoracentesisBert Govig, MD and Marc Baltzan, MDBert Govig, MDSir Mortimer B. Davis Jewish General Hospital; Montreal, Quebec J9T-252; CanadaSearch for more papers by this author and Marc Baltzan, MDSir Mortimer B. Davis Jewish General Hospital; Montreal, Quebec J9T-252; CanadaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-8-199404150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although thoracentesis is generally considered to be well tolerated and safe, variations in the thoracentesis catheter, the need for ultrasound guidance, and the experience required of the person doing the procedure have all been questioned [1-4]. In our search for a safer method of thoracentesis, we have begun doing diagnostic thoracentesis using a Vacutainer (Becton-Dickinson, Rutherford, New Jersey) blood-taking apparatus in a manner similar to that used in blood taking. The prepared skin is penetrated with the needle, and suction is applied while the needle is still in the soft tissue. The needle is then advanced into ...References1. Bartter T, Mayo PD, Pratter MR, Santarelli RJ, Leeds WM, Akers SM. Lower risk and higher yield for thoracentesis when performed by experienced operators. Chest. 1993; 103:1873-6. Google Scholar2. Grogan DR, Irwin RS, Channick R, Raptopoulos V, Curley FJ, Bartter T, et al. Complications associated with thoracentesis: a prospective, randomized study comparing three different methods. Arch Intern Med. 1990; 150:873-7. Google Scholar3. Collins TR, Sahn SA. Thoracocentesis: clinical value, complications, technical problems, and patient experience. Chest. 1987; 91:817-22. Google Scholar4. Seneff MG, Corwin RW, Gold LH, Irwin RS. Complications associated with thoracocentesis. Chest. 1986; 90:97-100. Google Scholar Author, Article, and Disclosure InformationAffiliations: Sir Mortimer B. Davis Jewish General Hospital; Montreal, Quebec J9T-252; Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1994Volume 120, Issue 8Page: 695-696KeywordsBloodBody fluidsCathetersForecastingPhlebotomySafety studiesSoft tissuesThoraxUltrasound imagingVacutainer Issue Published: 15 April 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Endoscopic Closure of Esophagothoracocutaneous Fistula with Collagen Plug and Fibrin Glue
Authors: J. Solt, I. Benkö, Z. Papp
Journal: Endoscopy (2001)

Endoscopic closure of an esophageal fistula without concomitant stenosis can be achieved either by using one of the sealing methods [1] [2] , by application of a mechanical device [3] [4] , or by using a combination of these two approaches [2] [5] . In the case of a benign fistula one must apply definitive curative therapy. Endoscopic closure of the inner opening of an esophagothoracocutaneous fistula, using a collagen plug originally developed for closing arteriography pinochles and fibrin glue, is reported.
STUDIES OF THE PROCESS OF AGING: FACTORS THAT INFLUENCE THE PSYCHE OF ELDERLY PERSONS
Authors: EWALD W. BUSSE, ROBERT H. BARNES, ALBERT J. SILVERMAN, G. MILTON SHY, MARGARET THALER, LAURENCE L FROST
Journal: American Journal of Psychiatry (1954)

1. The cortical activity of persons over the age of 60 shows a definite change as measured by the EEG. A high percentage have focal dysrhythmias which are primarily found in the left temporal areas. The presence of this focal dysrhythmia alone does not seem to impair psychological function, rather there is questionable evidence that it is associated with more flexibility and an increased ability to learn new patterns. In contrast, a diffuse slowing is accompanied by intellectual deterioration. 2. Guilt is not an important psychic determinant in elderly persons and is not the major cause of feelings of depression. Depression is more often related to loss of self-esteem because of feelings of inferiority. 3. A poor relationship between old people and their children is a part of a lifelong pattern of neurotic and immature behavior. 4. Psychologically, elderly persons who continue to work beyond the usual age of retirement have a higher intellectual capacity than those who do not. All of these findings raise many questions which require further thought and investigation before we have achieved a reasonable and useable knowledge of the factors that influence the psyche of elderly persons.
The Benefits and Harms of Mammography Screening
Authors: Steven Woloshin, Lisa M. Schwartz
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Overuse of Papanicolaou Testing Among Older Women and Among Women Without a Cervix
Authors: Deanna Kepka, Nancy Breen, Jessica B. King, Vicki B. Benard, Mona Saraiya
Journal: JAMA Internal Medicine (2013)

Leading national organizations are increasingly using evidence-based recommendations for Papanicolaou testing. As of 2003, organizations recommended against Papanicolaou testing for women without a cervix following a hysterectomy who do not have a history of high-grade precancerous lesion or cervical cancer and for women older than 65 years with adequate prior screening and who are not at high risk.1–3 Few studies have investigated overuse of Papanicolaou testing among US women. We aimed to investigate overuse of Papanicolaou testing in relation to cervical cancer screening recommendations.
Male New Zealand Black/KN mice: a novel model for autoimmune-induced permanent alopecia?
Authors: A. Hiroi, T. Ito, N. Seo, K. Uede, T. Yoshimasu, M. Ito, K. Nakamura, N. Ito, R. Paus, F. Furukawa
Journal: British Journal of Dermatology (2006)

Background Irreversible, permanent and scarring alopecia is associated with several autoimmune diseases, including all autoimmune connective tissue disorders. The pathogenesis of autoimmune‐induced permanent alopecia (APA) is still poorly understood, and instructive, simple mouse models for the study of APA are needed urgently. During the course of our studies in a well‐established mouse model for chronic rheumatoid arthritis, the New Zealand Black/KN (NZB/KN) mouse, we noticed that ageing male NZB/KN mice developed spontaneous APA. Objectives To study whether alopecia seen in ageing male NZB/KN mice displays key features of human APA and may, thus, be a useful new mouse model for clinically relevant APA research. Methods NZB/KN, the F1 hybrid of NZW/N Slc × NZB/KN (W/BKN F1), the F1 hybrid of NZB/KN × NZW/N Slc (BKN/W F1), and the F2 hybrid of W/BKN F1 × W/BKN F1 mice were employed in this study, in order to check which strain carries the highest risk of alopecia development. Besides routine histology, CD3, CD4 and CD8 expression as well as immunoglobulin (Ig) G and IgM deposition in hair follicles were investigated by immunohistology/immunofluorescence. Mast cell distribution/degranulation and Ki‐67 (proliferation)/TUNEL (terminal deoxynucleotidyl transferase‐mediated dUTP‐biotin nick end labelling) (apoptosis) positive cells were also analysed. Results Only F2 male NZB/KN mice were prone to develop alopecia, suggesting that Y chromosome‐associated gene(s) are involved in the pathogenesis of APA, which incidence rises with increasing age. The lesional alopecia skin in 12‐month‐old male NZB/KN mice showed a sharp decline in hair follicle density, thus meeting a key criterion of permanent alopecia. Both macroscopically and histologically, the alopecia seen in these mice resembled in many respects different stages of clinical APA, such as alopecia associated with chronic discoid lupus erythematosus (DLE) in humans. Lesional APA hair follicles in mice displayed intrafollicular and perifollicular mononuclear cell infiltrates, as well as an increased number of activated (degranulated) perifollicular mast cells. In the fully developed lesion, many CD4+ cells were seen in perifollicular locations, including the epithelial stem cell region (bulge), and also contained a few CD8+ T cells. IgM deposits were found in the follicular basement membrane zone (BMZ). Both in the bulge and the hair matrix region of the affected anagen hair follicles, there were signs of massive keratinocyte apoptosis. Conclusions Our currently available data suggest that male but not female NZB/KN mice may indeed represent a suitable mouse model for APA, with some similarities to the permanent alopecia seen in human DLE patients, although additional and confirmatory investigations are needed before this mouse strain can be accepted as a murine equivalent of APA in humans.
Visceral Larva Migrans
Authors: Douglas C. Heiner, Sherwin V. Kevy
Journal: New England Journal of Medicine (1956)

VISCERAL larva migrans, a syndrome with a wide variety of manifestations, is frequently not recognized. It has implications of importance to all physicians. Beaver et al.1 and Smith and Beaver2 have shown that this syndrome is caused by the ingestion of embryonated ova of dog or cat roundworms (Toxocara canis or Toxocara mystax). Similar syndromes are caused by other parasites.3 , 4 The most consistent finding in visceral larva migrans has been a leukocytosis with marked esosinophilia. White-cell counts usually range from 12,000 to 100,000, with eosinophils making up 15 to 80 per cent of the total. Eosinophilia may persist for several . . .
1163-109 Ongoing myocardial damage in severe heart failure: Prognostic usefulness of cardiac troponin T monitoring to identifying high-risk patients
Authors: Eduardo R Perna, Stella M Macin, Juan P Cimbaro Canella, Natalia Augier, Ariel E Pitzus, Jorge L Riera Stival, Jorge Cialzeta, Edgar Garcia, Alejandro Barbagelata, Eloisa Jantus
Journal: Journal of the American College of Cardiology (2004)
Cytarabine for Herpesvirus Infections
Authors: William Hryniuk
Journal: JAMA (1972)

The antileukemic agent cytarabine has recently been used to treat herpesvirus infections, but the regimens advocated for this purpose are high-dose prolonged infusions (100 mg/sq m of body surface per day for five days). The use of cytarabine as an antiviral agent has been restricted by the toxic effects produced with these regimens. We have treated ten patients with herpesvirus infections of wide range of severity using cytarabine infusions ranging from 10 to 100 mg/sq m /day for 1 1/2 to 7 days. In each case, the viral infection responded favorably soon after cytarabine therapy was started, even when low doses were given for short periods. The low-dose short-period infusions produced few toxic effects. Thus, cytarabine may be more useful as an antiviral agent than has previously been realized. Controlled studies are required to confirm this clinical impression.
The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture
Authors: Jillian L Astarita, Viviana Cremasco, Jianxin Fu, Max C Darnell, James R Peck, Janice M Nieves-Bonilla, Kai Song, Yuji Kondo, Matthew C Woodruff, Alvin Gogineni, Lucas Onder, Burkhard Ludewig, Robby M Weimer, Michael C Carroll, David J Mooney, Lijun Xia, Shannon J Turley
Journal: Nature Immunology (2014)
Treatment of Ménétrier's Disease with a Monoclonal Antibody against the Epidermal Growth Factor Receptor
Authors: J. Steven Burdick, EunKyung Chung, Gordon Tanner, Mei Sun, June E. Paciga, Jin Q. Cheng, Kay Washington, James R. Goldenring, Robert J. Coffey
Journal: New England Journal of Medicine (2000)

MEnEtrier's disease (hypoproteinemic hypertrophic gastropathy) is a rare, acquired, premalignant disorder of the stomach.1–4 It is characterized by giant hypertrophic folds that most often involve the fundus, excess mucus secretion, decreased acid secretion (hypochlorhydria), and hypoproteinemia due to selective loss of serum proteins across the gastric mucosa.5,6 The cause of Menetrier's disease is unknown, although infection with cytomegalovirus (CMV) in children and infection with Helicobacter pylori have been implicated.7,8 Symptoms include epigastric pain, vomiting, edema, anorexia, and weight loss. Gastric cancer has been reported at diagnosis or during follow-up in patients with hypertrophic gastropathy. Evidence of the . . .
Proceedings of the fifty-ninth annual meeting of the American Society for Clinical Investigation, Inc., held in Atlantic City, N. J., May 1, 1967. Presidential address. The mores of clinical investigation.
Authors: G W Liddle
Journal: Journal of Clinical Investigation (1967)

During recent years public discussion concerning the mores of clinical investigation has reached such a cres- cendo that the time has come for us as clinical investigators to define the mores that govern our actions.
Immunology and Immunopathology of Legionnaires' Disease
Authors: PETER A. WARD
Journal: Annals of Internal Medicine (1979)

The immune response to the Legionnaires' disease (LD) bacterium has been shown serologically. Recent evidence suggests significant differences in seroreactivity depending on the source of antigen; these data now unequivocally show strain variation for the LD bacterium. Nothing is known about the cellular immune reactivity in patients with Legionnaires' disease. There is little evidence that the lesions and manifestations of the disease are due to immunopathologic mechanisms. Possible explanations for the pathogenesis of pulmonary lesions in Legionnaires' disease include toxic factors, bacterial chemotactic factors, neutral proteases (with complement cleaving activity), lipopolysaccharides, and products of lymphocytes.
Sex differences in speed of emergence and quality of recovery after anaesthesia: cohort study
Authors: Paul S Myles, Andrew D M McLeod, Jennifer O Hunt, Helen Fletcher
Journal: BMJ (2001)

Recent evidence shows that postoperative recovery may differ between men and women. 1 2 We planned a prospective cohort study to examine the impact of gender on postoperative outcome.This was associated with a trial investigating the effectiveness of several anaesthetic regimens.
Abstract 4911: HPV-independent methylation of specific TGF-B pathway-relevant genes in head and neck squamous cell carcinomas associated with prior radiation therapy and exposure to alcohol and tobacco
Authors: Kristi L. Bennett, Todd Romigh, Walter Lee, Eric Lamarre, Xiatong Zhang, Rahul Seth, Joseph Scharpf, Jennifer Hunt, Charis Eng
Journal: Cancer Research (2010)

Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with more than half a million people being diagnosed with the disease annually. Therefore, it is critical to identify early detection markers, such as DNA methylation, for more timely diagnosis. In a recent study, we identified five tumor suppressive genes (IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18) as frequently methylated in HNSCC biopsies using a global methylation analysis via restriction landmark genomic scanning (RLGS). Interestingly, we found these candidates are all potentially involved in the TGF-B signaling pathway, which is often disrupted in HNSCC. Therefore, we sought to determine coordinated epigenetic silencing of these candidate genes in HNSCC as potential key disruptors of TGF-B signaling, which could ultimately result in HNSCC progression. Through immunoprecipitation studies, all five of the investigated candidate genes were found to interact with components of the TGF-B pathway. Also, overexpression of SLC5A8, EBF3, and IRX1 resulted in decreased mitotic activity and increased apoptosis. These findings are significant because they reveal a set of genes that interact with components of the TGF-B pathway, and their silencing via methylation in HNSCC results in coordinated decrease in apoptosis, increased proliferation, and decreased differentiation. We went on to define the methylation of these genes in relationship to HPV16-positivity, radiation therapy, and alcohol and tobacco exposure. By utilizing the available clinical information linked to the patient specimens, we found a strong association between promoter methylation of FUSSEL18, IRX1, and EBF3 and prior radiation therapy (P &amp;lt; 0.0001) irrespective of HPV status. Also, promoter methylation of FUSSEL18 and SEPTIN9 were found to correlate significantly with exposure to alcohol and tobacco (P = 0.021). Importantly, in this study we preliminarily show a trend between HPV16 positivity and specific target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. Equally notable and independent of HPV status, hypermethylation of the promoters of a subset of these genes in recurrences especially in the setting of prior radiation or in the setting of alcohol and tobacco use might help guide adjunctive inclusion or exclusion or epigenetic therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4911.
RECEPTORS ON IMMUNOCOMPETENT CELLS
Authors: Joseph M. Davie, William E. Paul
Journal: The Journal of Experimental Medicine (1972)

During the course of the immune response to dinitrophenylated guinea pig albumin (DNP-GPA), a striking and parallel increase in avidity for epsilon-DNP-L-lysine occurs in the receptors on antigen-binding lymphocytes, antibody secreted by individual plaque-forming cells, and serum antibody molecules. A detailed analysis of the avidity distribution of antibody produced by plaque-forming cells indicates that this "immunologic maturation" is primarily due to a preservation of the high avidity subpopulation and a striking loss in the low avidity population rather than to sequential appearance of these cells. Moreover, the demonstration of the increased avidity of receptors of antigen-binding lymphocytes, which appear to be precursors of antibody-synthesizing cells, strongly suggests that the antigen-driven selectional process operates primarily on this cell type.
Unusual severe development of common B lymphoblastic leukemia in Gaucher disease type I
Authors: Roberto Castelli, Elena Cassinerio, Alessandra Iurlo, Alberto Zanella, Umberto Gianelli, Maria Domenica Cappellini
Journal: American Journal of Hematology (2006)

To the Editor: Granulocytic sarcoma, a localized tumor mass composed of immature cells derived from the hematopoietic myeloid series, could infiltrate any extramedullary site; however, mediastinal involvement is distinctly rare [1].A patient who presented cardiac tamponade and superior vena cava obstruction caused by granulocytic sarcoma is described.A 45-year-old woman presented with a 1-month history of general discomfort, anorexia, and pain on the left costosternal zone.The chest X-ray was normal.Four weeks later, dyspnea appeared on moderate effort.On admission, she had orthopnea, elevated jugular venous pressure, regular tachycardia, normal blood pressure, distant heart sounds, and bilateral leg swelling.Hepatomegaly and lympha-denopathy were absent.Chest X-ray now showed an enlarged cardiac silhouette and a moderate right pleural effusion.Electrocardiogram showed sinus tachycardia and low voltage.Laboratory test showed a haemoglobin level of 80 g/L, and ESR of 62 mm/hr.There were no abnormal cells.Thoracocentesis showed an inflammatory exudate with absence of malignant cells.On the fifth hospital day, the patient had increased dyspnea, marked distension of jugular venous, Kuss-maul sign, pulsus paradoxus of 20 mmHg, and hypotension.An echocardiogram disclosed a large pericardial effusion with cardiac tamponade (Fig. 1), and 750 mL of bloody fluid was removed.Pericardial fluid and biopsy were negative for malignancy.A full-body CT scan showed (Fig. 2) findings highly suggestive of thoracic lymphoma and a superior vena cava obstruction.Bone marrow biopsy was normal.A mediastinum biopsy revealed a granulocytic sarcoma.Immunophenotypic analysis of the blasts showed positive cytoplasmic staining for myeloid markers (MPO), CD34 þ , CD68 þ , and HLA-DR þ .Cytogenetic analysis revealed following karyotype: þ4, -9, -17, add (17)(p13), -18, þ21, þ22.The disease remained refractory to chemotherapy (idarubicin, cytarabine, and hydroxyurea), and the patient expired in multiorgan failure, 13 weeks after clinical onset.Granulocytic sarcoma can infiltrate different organs, including bone, skin, lymph nodes, lung, breast, and central nervous system.Mediastinal involvement in hematological malignancy is always considered exclusively of lymphoid origin [2].However, a few reports of mediastinal granulocytic sarcoma with features of superior vena cava obstruction have been described [2,3].Malignant involvement