Chronic Myocardial Ischemia and Left Ventricular Function
Authors: ABDULMASSIH S. ISKANDRIAN
Journal: Annals of Internal Medicine (1987)

Editorials1 December 1987Chronic Myocardial Ischemia and Left Ventricular FunctionABDULMASSIH S. ISKANDRIAN, M.D., JAEKYEONG HEO, M.D., RICHARD H. HELFANT, M.D., BERNARD L. SEGAL, M.D.ABDULMASSIH S. ISKANDRIAN, M.D., JAEKYEONG HEO, M.D., RICHARD H. HELFANT, M.D., BERNARD L. SEGAL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-6-925 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExperimental studies show that brief episodes of myocardial ischemia result in changes in regional left ventricular systolic shortening that normalize after restoration of coronary blood flow. Since our original work in the characterization of left ventricular asynergy based on interventions done in the catheterization laboratory first appeared, other imaging techniques and renewed interest in the role of ischemia in left ventricular dysfunction have emerged (1-3).The autoregulatory mechanisms that attempt to maintain a normal resting coronary blood flow in the presence of severe coronary stenosis may fail in some patients. Although a persistent decrease in resting flow may not be...References1. HELFANT R, BODENHEIMER M, and BANKA V. Asynergy in coronary heart disease: evolving clinical and pathophysiologic concepts. Ann Intern Med. 1977;87:475-82. LinkGoogle Scholar2. BANKA V, BODENHEIMER M, SHAH R, and HELFANT R. Intervention ventriculography: comparative value of nitroglycerin, post-extrasystolic potentiation and nitroglycerin plus post-extrasystolic potentiation. Circulation. 1976;53:632-7. CrossrefMedlineGoogle Scholar3. 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Improved regional ventricular function after successful surgical revascularization. J Am Coll Cardiol. 1984;3:902-8. CrossrefMedlineGoogle Scholar8. TOPOL E, WEISS J, and GUZMAN P. Immediate improvement of dysfunctional myocardial segments after coronary revascularization detection by intraoperative transesophageal echocardiography. J Am Coll Cardiol. 1984;4:1123-34. CrossrefMedlineGoogle Scholar9. ALDERMAN E, FISHER L, and LITWIN P. Results of coronary artery surgery in patients with poor left ventricular function (CASS). Circulation. 1983;68:785-95. CrossrefMedlineGoogle Scholar10. HELFANT R, PINE R, MEISTER S, FELDMAN M, TROUT R, and BANKA V. Nitroglycerin to unmask reversible asynergy: correlation with post coronary bypass ventriculography. Circulation. 1974;50:108-13. CrossrefMedlineGoogle Scholar11. POPIO K, GORLIN R, BECHTEL D, and LEVINE J. Postextrasystolic potentiation as a predictor of potential myocardial viability: preoperative analyses compared with studies after coronary bypass surgery. Am J Cardiol. 1977;39:944-53. CrossrefMedlineGoogle Scholar12. NESTO R, COHN L, COLLINS J, WYNNE J, HOLMAN L, and COHN P. Inotropic contractile reserve: a useful predictor of increased 5 year survival and improved postoperative left ventricular function in patients with coronary artery disease and reduced ejection fraction. Am J Cardiol. 1982;50:39-44. CrossrefMedlineGoogle Scholar13. BODENHEIMER M, BANKA V, FOOSHEE C, HERMANN G, and HELFANT R. Relationship between regional myocardial perfusion and the presence, severity and reversibility of asynergy in patients with coronary heart disease. Circulation. 1978;58:789-95. CrossrefMedlineGoogle Scholar14. DYKE S, COHN P, GORLIN R, and SONNENBLICK E. Detection of residual myocardial function in coronary artery disease using post-extrasystolic potentiation. Circulation. 1974;50:694-9. 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TILLISCH J, BRUNKEN R, and MARSHALL R. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med. 1986;314:884-8. CrossrefMedlineGoogle Scholar20. KENNEDY P, CORBETT J, and KULKARNI P. Iodine 123-phenylpentadecanoic acid myocardial scintigraphy: usefulness in the identification of myocardial ischemia. Circulation. 1986;52:408-12. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ABDULMASSIH S. ISKANDRIAN, M.D.; JAEKYEONG HEO, M.D.; RICHARD H. HELFANT, M.D.; BERNARD L. SEGAL, M.D.Affiliations: Philadelphia Heart Institute Presbyterian-University of Pennsylvania Medical Center Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMyocardial ViabilityMyocardial viability: Methods of assessment and clinical relevanceMagnetic Resonance Techniques for Assessment of Myocardial ViabilityMagnetic Resonance Techniques for Assessment of Myocardial ViabilityMagnetic resonance techniques for the assessment of myocardial viability: Clinical experienceWhen is myocardial viability a clinically relevant issue?Magnetic resonance techniques for the assessment of myocardial viabilityA comparison of rest sestamibi and rest-redistribution thallium single photon emission tomography: Possible implications for myocardial viability detection in infarcted patientsThe clinical relevance of myocardial viability in patient managementReverse redistribution on Tl-201 SPECT images after reperfusion therapy for acute myocardial infarction: Possible mechanism and prognostic implicationsDivergent kinetics of 201Tl and 99mTc-SESTAMIBI in cultured chick ventricular myocytes during ATP depletion.Assessment of myocardial viability with scintigraphic techniques and magnetic resonance imaging: new attainments?Assessment of myocardial viabilityReversible segmental left ventricular dysfunction after coronary angioplasty.Exercise training after anterior Q wave myocardial infarction: Harmful or beneficial 1 December 1987Volume 107, Issue 6Page: 925-927KeywordsBlood flowCatheterizationImaging techniquesIschemiaResearch laboratoriesStenosis ePublished: 1 December 2008 Issue Published: 1 December 1987 PDF downloadLoading ...