tbuckley/cabot-search huggingface dataset:
Ceftazidime-resistant Klebsiella
Authors: James J. Rahal
Journal: Annals of Internal Medicine (1994)

Letters15 March 1994Ceftazidime-resistant KlebsiellaJames J. Rahal, MD and Carl Urban, PhDJames J. Rahal, MDThe New York Hospital Medical Center of Queens; Flushing, NY 11355Search for more papers by this author and Carl Urban, PhDThe New York Hospital Medical Center of Queens; Flushing, NY 11355Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-6-199403150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The relation between antibiotic resistance and the extent to which organisms are exposed to these agents is well known [1]. The specificity, intensity, and duration of exposure are the important variables. We suspect that inclusion of Klebsiella in the survey of ceftazidime resistance will eventually show the effect of antibiotic pressure on the selection of resistant strains, albeit more slowly because of the difference in the magnitude of ceftazidime use. Our experience is not isolated, as shown by an unpublished multihospital survey [2]. Conducted after recognition of our outbreak, it identified ceftazidime-resistant Klebsiella pneumoniae within intensive care units ...References1. Cohen ML. Epidemiology of drug resistance: implications for a post antimicrobial era. Science. 1992; 257:1050-5. Google Scholar2. U.S.I.C.U. Surveillance Study, 1990-1993. West Point, Pennsylvania: Merck and Co., Inc.; 1993. Google Scholar3. Medeiros AA. Nosocomial outbreaks of multiresistant bacteria. Extended-spectrum β-lactamases have arrived in North America. Ann Intern Med. 1993; 119:428-9. Google Scholar4. Rice LB, Willey SH, Papanicolau GA, Medeiros AA, Eliopoulos GM, Moellering RC Jr, et al. Outbreak of ceftazidime resistance caused by extended spectrum β-lactamases at a Massachusetts chronic-care facility. Antimicrob Agents Chemother. 1990; 34:2193-9. Google Scholar5. Naumovski L, Quinn JP, Miyashiro D, Patel M, Bush K, Singer SB, et al. Outbreak of ceftazidime resistance due to a novel extended-spectrum β-lactamase in isolates from cancer patients. Antimicrob Agents Chemother. 1992; 36:1991-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: The New York Hospital Medical Center of Queens; Flushing, NY 11355 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1994Volume 120, Issue 6Page: 522KeywordsAntibiotic resistanceAntibioticsAntimicrobial resistanceAntimicrobialsIntensive care unitsKlebsiellaKlebsiella pneumoniaePneumoniaRetrospective studiesSpecificity Issue Published: 15 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Maternal Bonding in Early Fetal Ultrasound Examinations
Authors: John C. Fletcher, Mark I. Evans
Journal: New England Journal of Medicine (1983)

WE have recently seen two cases in which women in the late first or early second trimester of pregnancy reported feelings and thoughts clearly indicating a bond of loyalty toward the fetus that we and others1 had associated only with a later stage of fetal development. We were impressed with the potential importance of many other similar events. We report these cases and our reflections to encourage more systematic study of two questions: Does parental viewing of the early fetus (before "quickening") by means of ultrasound imaging accelerate bonding with the fetus? If so, what are the medical, emotional, and . . .
The Silence of the Body: Materials for the Study of Medicine
Authors: A. Mark Clarfield
Journal: JAMA (1995)

This is a very weird book and one that I did not much enjoy. When I began my review, I dutifully did read each word. However, as I worked my way through the book, I gradually began to skim, skipping from page to page ever more quickly. By the time the end came, I was relieved to be through. This volume had potential. As one of the blurbs puts it, "[The book] is meant to be a scrap-book of observations collected over the years on a subject that impassions [the author]: the body." It is a collection of such meanderings, and some of the items collected by Ceronetti, an Italian literary critic, are true gems. For example, as an alternative to a gross Anglo-Saxonism, which all North American schoolchildren are familiar with, he offers us an elegant Latin phrase: "<i>Quod turget, urget</i>(what swells, impels)." Or in a rambling, otherwise
AN UNUSUAL CARPAL FRACTURE DISLOCATION: REPORT OF CASE
Authors: George L. Apfelbach
Journal: JAMA (1934)

In reviewing the literature of the past ten years on carpal injuries we have been unable to find a reference to any case in which a fragment of the navicular bone and the entire lunate were dislocated into the volar surface of the lower third of the forearm.  In order to permit such a displacement between the flexor tendons, the annular ligament of the wrist must have been torn.  This case is being reported because the bones were dislocated so far from their normal position and because the end result of carpalectomy was excellent.  W. L., a Negro girl, aged 17 years, admitted to the Cook County Hospital, March 12, 1933, was in a condition of serious shock. While washing windows, she fell out of a fourth story window, landing in a cement courtyard.  The injuries are enumerated as follows:   Basal skull fracture with bilateral ecchymosis of the orbits
Characterization of the t(14;18) <b> <i>BCL2-IGH</i> </b> Translocation in Farmers Occupationally Exposed to Pesticides
Authors: Sandrine Roulland, Pierre Lebailly, Yannick Lecluse, Mélanie Briand, Didier Pottier, Pascal Gauduchon
Journal: Cancer Research (2004)

Abstract Increasing incidence of non-Hodgkin’s lymphoma have been associated repeatedly with farming occupation and particular attention focused on the role of pesticide exposure to potentially explain part of this trend. A genetic hallmark of non-Hodgkin’s lymphoma is the presence of recurrent chromosomal translocations involving the immunoglobulin heavy chain gene. Of these, the t(14;18), which deregulates BCL2 expression and inhibits apoptosis, is the most frequent in follicular lymphoma and has been detected consistently in peripheral blood lymphocytes of healthy individuals. As BCL2-IGH translocation represents an early step of the malignant process, we evaluated the occurrence and molecular characteristics of BCL2-IGH translocation in 56 individuals occupationally exposed to pesticides in open field farming They were selected from a representative cohort of farmers with a well-defined assessment of pesticide exposure taking into account potential confounding factors, smoking, sunlight, and age. Our results suggest that occupational exposure to pesticides would increase BCL2-IGH prevalence together with the frequency of BCL2-IGH-bearing cells especially during the high pesticide use period. Distribution of BCL2 or IGH breakpoint positions seemed to be independent of pesticide exposure and was similar to those found in other healthy populations or lymphoma patients. Finally, these results provide additional evidence that BCL2-IGH translocation measurements could be a measure of acquired genetic instability in relation to genotoxic exposure in a gene directly relevant in term of lymphomagenesis.
140. Enhanced Cell Killing Effect of E1 Modified Adenoviruses Expressing HSV-TK Suicide Gene
Authors: Oh-Joon Kwon, Dong Hyun Ko, Jing Hwa Huang, Il-Kyu Choi, Sung-Mi Jung, Joo-Hang Kim, Byoung Chul Cho, Chae-Ok Yun
Journal: Molecular Therapy (2006)

To combine the advantages of the prodrug/suicide gene approach with that of replicating adenoviruses, we have developed replicating adenoviral vectors harboring HSV-TK, generating Ad-ΔE1B19-TK, Ad-ΔE1B55-TK, Ad-ΔE1B19/55-TK adenoviruses. Infection with adenoviruses expressing HSV-TK increased the sensitivity of cells to GCV. Cell killing assay was used to compare the combined therapy with the two single therapy modalities and non-treated controls in human cancer cell line. The cytotoxicity of the combination therapy with replicating adenovirus and GCV was dramatically increased compared with replicating adenoviruses alone or replication incompetent adenovirus expressing TK.
Letter: Muscle mechanics.
Authors: D G Gordon
Journal: Circulation Research (1975)

characterized heart function by a classical mechanical analysis of the tension developed by myocardial wall fibers, and Archie (J Biomech 3:425-429, 1970) analyzed the physics of left ventricular ejection with focus on the pressure difference between the left ventricle and the aorta.Empirical measures of myocardial performance, such as dP/dt, are directly related to the former point of view, and other measures, such as maximum acceleration of the aortic blood, are related to the latter.Dr. Abbott and I have recently carried out calculations which show how a quantitative relationship between the two concepts can be obtained.We deliberately chose an oversimplified, though not completely unrealistic, biophysical model so that the mathematical formulations would not be so complex as to obscure the basic ideas.Accordingly, we assumed that the left ventricle was shaped like an ellipsoid of revolution and that it contracts in such a way that the major diameter stays fixed and the minor diameter shortens.The long axis of the ellipse was considered to bisect the aortic outflow tract.To calculate the pressure drop, AP, between the center of the ellipse and the aortic outflow tract, a choice of the proper fluid flow equation is necessary.The literature suggests that the flow in the ascending aorta is largely determined by the inertial laws of motion and that frictional forces play a minor role (Lighthill, J Fluid Mech 52:475, 1972).We therefore chose the inviscid, one-dimensional fluid flow equation (Gilbrech, Fluid Mech, 1965): dy d /tA _ 1 2P ~At + ~&z \~2/ p d ?
HOW TO PRODUCE MILK FOR INFANT FEEDING.
Authors: EDWARD F. BRUSH
Journal: JAMA (1904)

Many infants must be nourished artificially. The reasons for this are plain. Sometimes the mother is overworked, insufficiently nourished, harassed by a vicious husband and many other children, often incompetent by her Own unfortunate temper or a vicious appetite and indulgence or a vagrant desire for amusements, sometimes by an inability to secrete milk. The business of properly nourishing an infant is a serious one, and to be properly accomplished must be attended to with an intense sense of duty. The mother must be healthy, love her child, and not nurse it when she is seriously disturbed, either mentally or physically. I was called to see an infant in a severe convulsion. I found that the mother was very solicitous and affectionate. She had been so careful of her child that she did not even allow it to have a drink of water, feeling confident
Prescribing by numbers
Authors: J. Trowell
Journal: BMJ (1995)

When I first went into practice 70% of all our prescriptions came out of 12 numbered stock bottles in the dispensary. Each bottle was a different colour but they all had a fascinating clarity so that the sunlight coming in through the window and shining through the bottles made brilliant patches of light on the ceiling and walls as our dispenser went about her work.

Shortly after joining the practice I dared to ask her what the bottles contained. I did not know at that stage that she was the most formidable of all the members of the practice, a doctor's daughter with a degree. She told me that it was my duty to decide which bottle to prescribe for each patient and hers to decide what to put into the bottle.

By long tradition each bottle was used for a certain system, or …
New trial should clarify lithium use in bipolar disorder
Authors: J. Geddes
Journal: BMJ (2002)

EDITOR—We agree with Dinan's statement in his editorial that there is considerable evidence that lithium is an effective maintenance treatment in bipolar disorder.1 Our recent Cochrane review found that lithium reduced the relative risk of relapse in bipolar disorder by 42% (95% confidence interval 30% to 52%).2 We …
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis
Authors: Yotis A. Senis, Michael G. Tomlinson, Stuart Ellison, Alexandra Mazharian, Jenson Lim, Yan Zhao, Kristin N. Kornerup, Jocelyn M. Auger, Steve G. Thomas, Tarvinder Dhanjal, Neena Kalia, Jing W. Zhu, Arthur Weiss, Steve P. Watson
Journal: Blood (2009)
Central Venous Catheterization-Reply
Authors: Richard M. Nowak
Journal: JAMA (1982)

<h3>In Reply.—</h3> Dr Mitchell describes what we have found to be a common occurrence among physicians who have compared the SC and IC routes with subclavian vein catheterization. In our experience, there has been a preference for the SC approach, especially among the residents in emergency medicine, because it is both easier to perform and also associated with fewer complications. During CPR, the choice becomes even more clear. When simple alternatives to the IC subclavian venipuncture exist, it is difficult to justify either puncture of the mobile chest wall or the interruption of CPR. In this setting, we have found that internal jugular cannulation (middle approach) is technically more difficult than the SC subclavian route mainly because of interference with airway management. Furthermore, in those situations where the patient is volume depleted, the lack of ligamentous support that maintains the patency of the vein is not present with the jugular
CESAREAN SECTION MADE NECESSARY BY A VENTROFIXATION.
Authors: WM. M. FINDLEY
Journal: JAMA (1902)

Cesarean sections are not so numerous that any case is uninteresting or should not be reported even if success has not attended the efforts made for relief. Even want of success has its lessons and much may be learned which can be made profitable if heeded. <h3>THE DANGERS OF VENTROFIXATION.</h3> Much of value has been written in later years by such eminent authorities as Edebohls, New York; Burrage, Boston; Kelly, Baltimore; Noble and R. Wood, Philadelphia, and others as to the damages of ventrofixation in the child-bearing period, and yet the lesson does not seem to have been learned that ventrofixation during this period may become a very dangerous complication in pregnancy. The train of symptoms, for which women consult gynecologists, which require the operation of ventrofixation, are so well known that it is not necessary to recall them, and yet, would it not be better to allow a woman
Monomorphic Ventricular Tachycardia and Mediastinal Adenopathy Due to Granulomatous Infiltration in Patients With Preserved Ventricular Function
Authors: Ajit Thachil, Johann Christopher, B.K.S. Sastry, Kavitha Nallapa Reddy, Vijaya K. Tourani, Ashfaq Hassan, Bhupathiraju Soma Raju, Calambur Narasimhan
Journal: Journal of the American College of Cardiology (2011)
Cold agglutinin autoimmune hemolytic anemia in nonhematologic malignancies
Authors: J. Wortman, W. Rosse, G. Logue
Journal: American Journal of Hematology (1979)

Abstract Four patients with nonhematologic malignancies had the simultaneous finding of hemolytic anemia due to high‐titer cold agglutinins. In each patient, the cold agglutinin had “anti‐I” specificity and was of the IgM kappa immunoglobulin class. Although patients with hematologic malignancies not uncommonly have cold agglutinins, the association between these antibodies and nonhematologic malignancies is unusual.
The draft genome of the fast-growing non-timber forest species moso bamboo (Phyllostachys heterocycla)
Authors: Zhenhua Peng, Ying Lu, Lubin Li, Qiang Zhao, Qi Feng, Zhimin Gao, Hengyun Lu, Tao Hu, Na Yao, Kunyan Liu, Yan Li, Danlin Fan, Yunli Guo, Wenjun Li, Yiqi Lu, Qijun Weng, CongCong Zhou, Lei Zhang, Tao Huang, Yan Zhao, Chuanrang Zhu, Xinge Liu, Xuewen Yang, Tao Wang, Kun Miao, Caiyun Zhuang, Xiaolu Cao, Wenli Tang, Guanshui Liu, Yingli Liu, Jie Chen, Zhenjing Liu, Licai Yuan, Zhenhua Liu, Xuehui Huang, Tingting Lu, Benhua Fei, Zemin Ning, Bin Han, Zehui Jiang
Journal: Nature Genetics (2013)

Bin Han and colleagues report the draft genome of moso bamboo, an important non-timber forest product. RNA sequencing analysis of bamboo flowering tissues suggests a connection between drought-responsive genes and potential flowering genes. Bamboo represents the only major lineage of grasses that is native to forests and is one of the most important non-timber forest products in the world. However, no species in the Bambusoideae subfamily has been sequenced. Here, we report a high-quality draft genome sequence of moso bamboo (P. heterocycla var. pubescens). The 2.05-Gb assembly covers 95% of the genomic region. Gene prediction modeling identified 31,987 genes, most of which are supported by cDNA and deep RNA sequencing data. Analyses of clustered gene families and gene collinearity show that bamboo underwent whole-genome duplication 7–12 million years ago. Identification of gene families that are key in cell wall biosynthesis suggests that the whole-genome duplication event generated more gene duplicates involved in bamboo shoot development. RNA sequencing analysis of bamboo flowering tissues suggests a potential connection between drought-responsive and flowering genes.
Effect of beta-Carotene Supplementation on Indices of Colonic Cell Proliferation
Authors: T. O. Frommel, S. Mobarhan, M. Doria, A. G. Halline, G. D. Luk, P. E. Bowen, A. Candel, Y. Liao
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Effect of β-Carotene Supplementation on Indices of Colonic Cell Proliferation Get access Thomas O. Frommel, Thomas O. Frommel Department of Medicine, Division of Digestive Diseases and Nutrition Loyola UniversityMay-wood, IL Correspondence to: Thomas O. Frommel, Ph.D., Department of Medicine, Division of Digestive Diseases and Nutrition, Loyola University Medical Center, 2160 S. 1st Ave., Bldg. 117, Maywood, IL 60153. Search for other works by this author on: Oxford Academic PubMed Google Scholar Sohrab Mobarhan, Sohrab Mobarhan Department of Medicine, Division of Digestive Diseases and Nutrition Loyola UniversityMay-wood, IL Search for other works by this author on: Oxford Academic PubMed Google Scholar Manuel Doria, Manuel Doria SmithKIine Beccham Clinical LaboratoriesSchaumburg, IL Search for other works by this author on: Oxford Academic PubMed Google Scholar Allan G. Halline, Allan G. Halline Department of Medicine University of IllinoisChicago Search for other works by this author on: Oxford Academic PubMed Google Scholar Gordon D. Luk, Gordon D. Luk University of Texas Southwestern Medical CenterDallas Search for other works by this author on: Oxford Academic PubMed Google Scholar Phyllis E. Bowen, Phyllis E. Bowen Department of Nutrition and Medical Dietetics, University of IllinoisChicago Search for other works by this author on: Oxford Academic PubMed Google Scholar Alvaro Candel, Alvaro Candel Department of Pathology Loyola UniversityMay-wood, IL Search for other works by this author on: Oxford Academic PubMed Google Scholar Youlian Liao Youlian Liao Department of Preventive Medicine, Loyola UniversityMay-wood, IL Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 23, 6 December 1995, Pages 1781–1787, https://doi.org/10.1093/jnci/87.23.1781 Published: 06 December 1995 Article history Received: 30 March 1995 Revision received: 24 August 1995 Accepted: 12 September 1995 Published: 06 December 1995
Abstract 1207: Pharmacodynamic evaluation of ADCC mediated effects in humanized IL2 or IL15 NOG mice models
Authors: Caroline Mignard, Jean-Francois Mirjolet, Olivier Duchamp, Yasuyuki Ohnishi, Ikumi Katano, Mamoru Ito
Journal: Cancer Research (2014)

Abstract Humanized mice (i.e. immunodeficient NOG mice engrafted with human hematopoietic stem cells (HSC)) have demonstrated their usefulness for studying the human immune system. These models should help recapitulating some pathology such as viral infection and then are suitable system to evaluate new human specific therapies. Nevertheless, one issue of these models is the incomplete maturation of natural killer (NK) cell subpopulation. This lake of NK cell functionality was solved by the Central Institute for Experimental Animals (CIEA) with the second generation of transgenic NOG mice expressing human IL2 or IL15 (NK-NOG). The serum levels of hIL-2 and hIL-15 in mice were 1-2 and 0.1-0.2 ng/mL, respectively. In these mice, human NK cells differentiated from HSC are well distributed in the mouse body (peripheral blood, bone marrow, spleen…). They expressed various NK receptors such as NKp30, NKp44, NKp46, etc., granzyme A and perforin, indicating their maturity in the mice. They are also fully functional as evidenced using an ex vivo 51Cr release assay demonstrating lysis properties of human NK cells from collected spleen of HSC-humanized mice.In vivo proof of concept studies were successfully performed with humanized NK-NOG mice xenografted with either human Burkitt's disseminated lymphoma cells or with human solid tumors treated with humanized therapeutic antibodies. Prediction of ADCC-mediated antitumor activity of humanized antibodies is now routinely feasible for preclinical evaluation using these new in vivo NK-NOG models. Citation Format: Caroline Mignard, Jean-Francois Mirjolet, Olivier Duchamp, Yasuyuki Ohnishi, Ikumi Katano, Mamoru Ito. Pharmacodynamic evaluation of ADCC mediated effects in humanized IL2 or IL15 NOG mice models. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1207. doi:10.1158/1538-7445.AM2014-1207
More questions than answers in Mid Staffs mortality investigation
Authors: D. I. Ben-Tovim
Journal: BMJ (2013)

One indication of the problems at Mid Staffordshire Hospital was a consistently raised hospital standardised mortality ratio (HSMR). Hawkes investigated whether the BMJ was used as part of a “concerted effort” to discredit the HSMR.1 Hawkes examined the actions of all parties except those of the BMJ itself.

The 19 March 2009 edition of the BMJ …