tbuckley/cabot-search huggingface dataset:
John Anthony Seymour-Jones
Authors: R. Bale
Journal: BMJ (2008)

John Anthony Seymour-Jones was born on the 7 April 1911 in Birmingham. His father was an ear, nose, and throat surgeon. After attending Shrewsbury Public School, he won a classics scholarship to Gonville and Caius College, Cambridge, but later read natural sciences so that he could enter medicine.

He completed his clinical years at St Thomas’s, where he met his future wife, Elizabeth, …
Population Strategies to Decrease Sodium Intake
Authors: Puneet Narayan
Journal: Annals of Internal Medicine (2010)

Letters17 August 2010Population Strategies to Decrease Sodium IntakePuneet Narayan, MD and Anubhav Kumar, MSPuneet Narayan, MDFrom Clinical Research Institute of Northern Virginia, Burke, VA 22015.Search for more papers by this author and Anubhav Kumar, MSFrom Clinical Research Institute of Northern Virginia, Burke, VA 22015.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-4-201008170-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:If we expect to reduce salt consumption to improve the cardiovascular health of the nation, we have to involve patients and the general public in making informed decisions through education instead of the one-sided approach proposed by Smith-Spangler and colleagues (1). The media have covered high-profile efforts to legislate the use of salt in restaurants and eateries. The motivation behind these proposed laws is to reduce overconsumption of high-salt foods by Americans when they dine out. Unfortunately, regulating salt in restaurants will not have significant effects on population health. Before setting foot in our favorite restaurants, most ...Reference1. Smith-Spangler CM, Juusola JL, Enns EA, Owens DK, Garber AM. Population strategies to decrease sodium intake and the burden of cardiovascular disease: a cost-effectiveness analysis. Ann Intern Med. 2010;152:481-7, W170-3. [PMID: 20194225] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Puneet Narayan, MD; Anubhav Kumar, MSAffiliations: From Clinical Research Institute of Northern Virginia, Burke, VA 22015.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPopulation Strategies to Decrease Sodium Intake and the Burden of Cardiovascular Disease Crystal M. Smith-Spangler , Jessie L. Juusola , Eva A. Enns , Douglas K. Owens , and Alan M. Garber Population Strategies to Decrease Sodium Intake Crystal M. Smith-Spangler , Douglas K. Owens , and Alan M. Garber Population Strategies to Decrease Sodium Intake Mihaly Tapolyai Metrics 17 August 2010Volume 153, Issue 4Page: 276KeywordsCardiovascular diseasesEatingFoodForecastingHypertensionSaltsSedentary behaviorSodiumStrokeTaste ePublished: 17 August 2010 Issue Published: 17 August 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
EXTRACORONARY VASCULAR ABNORMALITIES ARE COMMON IN PATIENTS WITH SPONTANEOUS CORONARY ARTERY DISSECTION: ANALYSIS OF 72 PATIENTS AT A TERTIARY REFERRAL CENTER
Authors: Megha Prasad, Jackson Liang, Sharonne Hayes, Jerome Breen, Rajiv Gulati, Terri Vrtiska
Journal: Journal of the American College of Cardiology (2014)
Dnmt3a is essential for hematopoietic stem cell differentiation
Authors: Grant A Challen, Deqiang Sun, Mira Jeong, Min Luo, Jaroslav Jelinek, Jonathan S Berg, Christoph Bock, Aparna Vasanthakumar, Hongcang Gu, Yuanxin Xi, Shoudan Liang, Yue Lu, Gretchen J Darlington, Alexander Meissner, Jean-Pierre J Issa, Lucy A Godley, Wei Li, Margaret A Goodell
Journal: Nature Genetics (2011)
Rules for drug trials should be tightened, say experts
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

Experts have made a raft of recommendations about how early clinical studies of new drugs should be designed, to improve their safety for the people taking part.

An interim report from an expert scientific group chaired by Gordon Duff, professor of molecular medicine at Sheffield University and chairman of the government's Commission on Human Medicines, says that new high risk agents in phase I studies—the first time drugs are tested in humans—should be given to one …
Bronchial allergen challenge with isolated major allergens of Dermatophagoides pteronyssinus: The role of patient characteristics in the early asthmatic response
Authors: Maurits J. van der Veen, Christa E. Lopuhaä, Rob C. Aalberse, Henk M. Jansen, Jaring S. van der Zee
Journal: Journal of Allergy and Clinical Immunology (1998)
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like syndrome, and defective IL-10 expression from CD4 lymphocytes
Authors: Amy A. Caudy, Sreelatha T. Reddy, Talal Chatila, John P. Atkinson, James W. Verbsky
Journal: Journal of Allergy and Clinical Immunology (2006)
Uses and Limitations of Mortality and Health Care Utilization Statistics in Asthma Research
Authors: William M. Vollmer, Molly L. Osborne, A. Sonia Buist
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Mortality and health care utilization (HCU) statistics for asthma reflect both the acute and chronic aspects of this condition. We present a conceptual model that incorporates this dichotomy and also distinguishes between measures of disease occurrence (e.g., incidence and prevalence) and measures of disease management. We also discuss the use of mortality and HCU statistics in the literature, review their limitations and advantages, and make a number of general recommendations for their use.
Strategic Plan for Lung Vascular Research
Authors: Serpil Erzurum, Sharon I. Rounds, Troy Stevens, Micheala Aldred, Jason Aliotta, Stephen L. Archer, Kewal Asosingh, Robert Balaban, Natalie Bauer, Jahar Bhattacharya, Harm Bogaard, Gaurav Choudhary, Gerald W. Dorn, Raed Dweik, Karen Fagan, Michael Fallon, Toren Finkel, Mark Geraci, Mark T. Gladwin, Paul M. Hassoun, Marc Humbert, Naftali Kaminski, Steven M. Kawut, Joseph Loscalzo, Donald McDonald, Ivan F. McMurtry, John Newman, Mark Nicolls, Marlene Rabinovitch, Judy Shizuru, Masahiko Oka, Peter Polgar, David Rodman, Paul Schumacker, Kurt Stenmark, Rubin Tuder, Norbert Voelkel, Eugene Sullivan, Richard Weinshilboum, Mervin C. Yoder, Yingming Zhao, Dorothy Gail, Timothy M. Moore
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

The Division of Lung Diseases of the National Heart, Lung, and Blood Institute, with the Office of Rare Diseases Research, held a workshop to identify priority areas and strategic goals to enhance and accelerate research that will result in improved understanding of the lung vasculature, translational research needs, and ultimately the care of patients with pulmonary vascular diseases. Multidisciplinary experts with diverse experience in laboratory, translational, and clinical studies identified seven priority areas and discussed limitations in our current knowledge, technologies, and approaches. The focus for future research efforts include the following: (1) better characterizing vascular genotype-phenotype relationships and incorporating systems biology approaches when appropriate; (2) advancing our understanding of pulmonary vascular metabolic regulatory signaling in health and disease; (3) expanding our knowledge of the biologic relationships between the lung circulation and circulating elements, systemic vascular function, and right heart function and disease; (4) improving translational research for identifying disease-modifying therapies for the pulmonary hypertensive diseases; (5) establishing an appropriate and effective platform for advancing translational findings into clinical studies testing; and (6) developing the specific technologies and tools that will be enabling for these goals, such as question-guided imaging techniques and lung vascular investigator training programs. Recommendations from this workshop will be used within the Lung Vascular Biology and Disease Extramural Research Program for planning and strategic implementation purposes.
Men using IVF inadequately screened for cystic fibrosis
Authors: D. Spurgeon
Journal: BMJ (1999)

Infertile men who have used in vitro fertilisation or had successful surgery to enable them to father a child, could be putting their offspring at risk of cystic fibrosis because standard screening methods cannot detect many genetic mutations responsible for the condition.

This conclusion results from a Canadian study by a team led by Keith Jarvi, associate professor …
Allergic sensitisation to peanut may occur through inflamed skin
Authors: J Quint
Journal: Thorax (2003)

▴ Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood. N Engl J Med2003;348:977–85 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] The increasing incidence of peanut allergy prompted this group to look at the predisposing factors to the condition. A subgroup of 49 children with a clear history of peanut allergy was identified from the Avon longitudinal study (a … [1]: {openurl}?query=rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa013536%26rft_id%253Dinfo%253Apmid%252F12637607%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa013536&link_type=DOI [3]: /lookup/external-ref?access_num=12637607&link_type=MED&atom=%2Fthoraxjnl%2F58%2F6%2F469.atom [4]: /lookup/external-ref?access_num=000181465200002&link_type=ISI
How often are adverse events reported in English hospital statistics?
Authors: Paul Aylin, Shivani Tanna, Alex Bottle, Brian Jarman
Journal: BMJ (2004)

About 850 000 medical errors occur in NHS hospitals every year, resulting in 40 000 deaths.w1In the United Kingdom, the National Patient Safety Agency (NPSA) was created to learn from patient safety incidents occurring in the NHS.w2 In February 2004, it launched a new patient reporting system, drawing together reports of patient safety errors and systems failures provided by health professionals across England and Wales.w3 An adverse event can be defined as “an unintended injury caused by medical management rather than a disease process, resulting in death, life threatening illness, disability at the time of discharge, admission to hospital, or prolongation of hospital stay.” w4 A medical or surgical misadventure is an adverse event that might have been avoided if the patient had received ordinary standards of care. We look at four years of …
Immunoprotective haem oxygenase induction by ultraviolet A (320-400 nm) radiation in the mouse is inhibited in interferon-gamma null mice
Authors: V.E. Reeve, D. Domanski
Journal: British Journal of Dermatology (2003)

A protective role for the ultraviolet (UV) A waveband against immunosuppression induced by UVB (280-320 nm) radiation has been identified. The mechanism for UVA immunoprotection was found to involve two apparently unrelated mediators, the T-helper-1-associated proinflammatory cytokine interferon (IFN)-gamma and the UVA-induced redox-regulated stress protein, haem oxygenase (HO).To identify a relationship between these two immune regulators.The HO response to UVA radiation in the skin and liver was examined in mice with a targeted disruption of the IFN-gamma gene, known to be unresponsive to UVA photoimmunoprotection. Results IFN-gamma null mice did not respond to UVA irradiation with the normal upregulation of HO activity in either the irradiated skin or the liver. Injection of these mice with recombinant IFN-gamma previously shown to restore the UVA-photoimmunoprotective effect, here partially and dose-responsively restored their ability for induction of HO activity in both skin and liver following UVA irradiation.IFN-gamma appears to be a prerequisite for the immunoprotective induction of HO, although other mediators may also be involved. The UVA responsiveness of HO in an internal organ such as the liver suggests the existence of a soluble UVA-induced mediator from the skin, which may be IFN-gamma.
The effect of ultraviolet (UVB and PUVA) radiation on the expression of epidermal keratins
Authors: T. HORIO, H. MIYAUCHI, I. SINDHVANANDA, H. SOH, I. KUROKAWA, Y. ASADA
Journal: British Journal of Dermatology (1993)

Journal Article The effect of ultraviolet (UVB and PUVA) radiation on the expression of epidermal keratins Get access T. HORIO, T. HORIO Department of Dermatology, Kansai Medical University, Osaka, Japan Dr T. Horio, Department of Dermatology, Kansai Medical University, Fuumizono‐cho I, Moriguchi, Osaka 570, Japan. Search for other works by this author on: Oxford Academic Google Scholar H. MIYAUCHI, H. MIYAUCHI Department of Dermatology, Kansai Medical University, Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar I. SINDHVANANDA, I. SINDHVANANDA Department of Dermatology, Kansai Medical University, Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar H. SOH, H. SOH Department of Dermatology, Kansai Medical University, Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar I. KUROKAWA, I. KUROKAWA Department of Dermatology, Kansai Medical University, Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. ASADA Y. ASADA Department of Dermatology, Kansai Medical University, Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 128, Issue 1, 1 January 1993, Pages 10–15, https://doi.org/10.1111/j.1365-2133.1993.tb00139.x Published: 01 January 1993 Article history Accepted: 23 June 1992 Published: 01 January 1993
Delivery of 14C-lignocaine and blood flow to canine organs after coronary occlusion: a physical separation technique to measure drug concentration and microsphere blood flow in the same tissue sample
Authors: W. S WEINTRAUB, D. A HALGASH, R. E PATTERSON
Journal: Cardiovascular Research (1982)

Journal Article Delivery of 14C-lignocaine and blood flow to canine organs after coronary occlusion: a physical separation technique to measure drug concentration and microsphere blood flow in the same tissue sample Get access WILLIAM S WEINTRAUB, WILLIAM S WEINTRAUB * From the Division of Cardiology, Department of Medicine, Mount Sinai School of Medicine, New York *Current address and address for reprints: William S Weintraub, MD, Assistant Professor of Medicine, Cardiology Division, Presbyterian-University of Penna Medical Center, Philadelphia, PA 19104, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar DORIS A HALGASH, DORIS A HALGASH From the Division of Cardiology, Department of Medicine, Mount Sinai School of Medicine, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar RANDOLPH E PATTERSON RANDOLPH E PATTERSON From the Division of Cardiology, Department of Medicine, Mount Sinai School of Medicine, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 16, Issue 6, June 1982, Pages 331–338, https://doi.org/10.1093/cvr/16.6.331 Published: 01 June 1982
Frequent Ventricular Ectopy after Exercise as a Predictor of Death
Authors: Joseph P. Frolkis, Claire E. Pothier, Eugene H. Blackstone, Michael S. Lauer
Journal: New England Journal of Medicine (2003)

Exercise-induced ventricular ectopy predicts an increased risk of death in population-based cohorts. We sought to examine in a clinical cohort the prognostic importance of ventricular ectopy immediately after exercise, when reactivation of parasympathetic activity occurs. We hypothesized that ventricular ectopy after exercise (i.e., during the recovery phase) would predict an increased risk of death better than ventricular ectopy during exercise.
Lesions in cerebrovascular disease and their clinical implications.
Authors: E C Hutchinson
Journal: BMJ (1972)

The clinical implications of advances in knowledge of the pathology of the stroke syndrome in the past 25 years are considerable. As the true role of cervical vessels disease in  infarction has become apparent so the diagnosis of cerebral thrombosis?implying in situ thrombus forma tion of the major vessels of the brain?is now recognized as a rare occurrence. The role of hypertension not merely as an adjuvant to the development of atherosclerosis but as a cause of primary disease in the  blood supply is gradually becoming appreciated, together with the implications for treatment. Though these two pathological processes?cerebral infarction and hypertension?account for the complaints of most patients presenting with  vascular disease, a small but important group of younger patients present with identical symptoms of  vascular disease but with diverse under lying pathological processes.
Steatosis in chronic hepatitis C: Relative contributions of obesity, diabetes mellitus, and alcohol
Authors: Alexander Monto, Judy Alonzo, Jessica J. Watson, Carl Grunfeld, Teresa L. Wright
Journal: Hepatology (2002)

Steatosis has emerged as a histologic finding of importance to the progression of hepatitis C virus (HCV)-associated liver disease. However, most studies of HCV-associated steatosis have excluded alcohol drinkers and individuals with diabetes and thus have not addressed the relative contribution of known causes of steatosis to liver injury in HCV-associated disease. To address this issue, we studied 297 consecutive patients with HCV who met inclusion criteria. Alcohol consumption, demographics, and serologic tests were correlated with degrees of steatosis and fibrosis on liver biopsy. Liver biopsy specimens were also examined for evidence of significant alcohol or nonalcoholic steatohepatitis (NASH) injury. In univariate analysis, steatosis correlated with type 2 diabetes mellitus ( P = .005) and body mass index (BMI) ( P = .0001) but not with the intensity of alcohol intake (in grams per day). In multivariate analysis, BMI ( P = .0002) and genotype 3a infection ( P = .02) were independent predictors of steatosis. When patients with risk factors for NASH were excluded, genotype 3a infection was the only independent predictor of steatosis. Steatosis ( P = .04) and inflammation ( P &lt; .0001) scores on liver biopsy were the only independent predictors of fibrosis. Significant alcohol or NASH injury was found in only 6% of biopsy specimens. In conclusion, steatosis in HCV infection is associated with risk factors for NASH, particularly obesity, rather than alcohol consumption.
Systemic Inhibition of Nitric Oxide Synthase Unmasks Neural Constraint of Maximal Myocardial Blood Flow in Humans
Authors: Philipp A. Kaufmann, Ornella Rimoldi, Tomaso Gnecchi-Ruscone, Robert S. Bonser, Thomas F. Lüscher, Paolo G. Camici
Journal: Circulation (2004)

Nitric oxide (NO) is an endothelial mediator that regulates vascular smooth muscle tone, but it may exert its cardiovascular action also by modulating the autonomic control of vasomotor tone. We assessed the effect of simultaneous inhibition of both endothelial (eNOS) and neuronal (nNOS) NO synthase isoforms on myocardial blood flow (MBF) and coronary flow reserve (CFR) in volunteers and in (denervated) transplant recipients.MBF (mL x min(-1) x g(-1)) was measured at rest and during adenosine-induced hyperemia with positron emission tomography and 15O-labeled water. CFR was calculated as adenosine/resting MBF. Measurements were repeated during one of the following intravenous infusions: group 1 (n=12), saline; group 2 (n=9), 3 mg/kg N(G)-monomethyl-L-arginine (L-NMMA), which crosses the blood-brain barrier and inhibits both eNOS and nNOS; group 3 (n=13), 10 mg/kg L-NMMA; group 4 (n=8), phenylephrine titrated to simulate the hemodynamic changes in group 3; and group 5 (n=6), 10 mg/kg L-NMMA infused into the heart transplant recipients. After intervention, hyperemic MBF and CFR were unchanged in groups 1, 2, and 4. By contrast, both hyperemic MBF (+53%, P<0.0001 versus baseline) and CFR (+52%, P<0.0001 versus baseline) increased in group 3, whereas they remained unchanged in group 5, which suggests that an intact cardiac innervation was required for the increase in MBF and CFR observed in group 3.The results of the present study suggest that maximal adenosine-induced hyperemia and CFR in humans are constrained by neurally mediated vasoconstriction, which can be relieved by systemic NOS inhibition with L-NMMA.
Perforation of the proximal esophagus treated with factor XIII
Authors: C. Knorr, R. Carbon, S. Albrecht, M. Richter, H. Köhler
Journal: Endoscopy (2008)

A 16-year-old girl presented to us with a perforated esophagus after accidental ingestion of a toothbrush. The referring physician had already tried to retrieve the brush endoscopically without success.
Sclerosing Cholangitis following Removal of an Echinococcus Cyst
Authors: A. Russo, G. Giannone, C. Virgilio
Journal: Endoscopy (1987)

Chez une femme de 58 ans, 8 mois apres une perikystectomie precedee d'une injection de formol. Le diagnostic d'angiocholite stenosante secondaire a ete etabli par tomodensitometrie et cholangiopancreatographie retrograde endoscopique
THE TREATMENT OF TYPE I PNEUMOCOCCUS LOBAR PNEUMONIA WITH SPECIFIC SERUM
Authors: EDWIN A. LOCKE
Journal: JAMA (1923)

It is now nearly ten years since Cole and his associates at the Hospital of the Rockefeller Institute for Medical Research began the use of specific antipneumococcus serum in the treatment of lobar pneumonia due to the Type I organism. In spite of the brilliant results from time to time reported from the Rockefeller Hospital, this method of treatment has not met with special favor. Indeed, during the last few years, there has developed a somewhat widespread and growing skepticism regarding the value of antipneumococcus serum in the treatment of lobar pneumonia due to this organism. Many physicians are inclined to class this method of treatment with the numerous vaunted remedies for pneumonia which have proved of little or no value, and in which medical literature abounds. The principal reasons why the Type I serum has not come into more general use are evident. The first and most important obstacle