tbuckley/cabot-search huggingface dataset:
Rehabilitation Management of Rheumatic Conditions
Authors: Susan Miller Paulson
Journal: JAMA (1986)

Oddly enough, the most valuable asset offered by<i>Rehabilitation Management of Rheumatic Conditions</i>is the wealth of information that this book can provide to those medical personnel who traditionally are not involved in the physical and emotional habilitation of the arthritic patient. In fact, it seems a shame that because of its title, most general practitioners, internists, and orthopedic surgeons will more than likely pass the book over, erroneously thinking that its true audience should consist only of physiatrists, occupational therapists, and physical therapists. On the contrary,<i>Rehabilitation Management of Rheumatic Conditions</i>is directed at every physician who will assume primary responsibility of the rheumatoid patient, because the book more than adequately demonstrates the so often forgotten concept of the multifaceted approach to the care of these special persons. Representatives of many specialties have provided input into this volume. In addition to the explanations of the more traditional roles played
Cost Control and Planning for NHI
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1978)

National health insurance (NHI) legislation has been waiting in the wings ever since Medicare and Medicaid first made their appearance over a decade ago. Numerous bills have been introduced in both houses of Congress, although none has yet generated wide enough support to be enacted into law. President Carter has said that he intends to propose his own NHI plan during this session of Congress, but few observers expect any serious consideration of the issue until after the next congressional elections. Although public-opinion polls show a majority of citizens in favor of the NHI idea, there is widespread concern about . . .
Family-Centered Advance Care Planning for Teens With Cancer
Authors: Maureen E. Lyon, Shana Jacobs, Linda Briggs, Yao Iris Cheng, Jichuan Wang
Journal: JAMA Pediatrics (2013)

Advance care planning (ACP) prepares patients and their families for future health care decisions; however, the needs of adolescent oncology patients for participation in ACP have not been well studied.To examine the efficacy of family-centered ACP.Two-group randomized controlled trial in a pediatric oncology program.Sixty adolescents aged 14 to 21 years with cancer and their surrogates or families were enrolled in the study between January 17, 2011, and March 29, 2012.Thirty dyads received 3- to 60-minute sessions 1 week apart. Intervention dyads completed (1) the Lyon Family-Centered ACP Survey, (2) the Respecting Choices interview, and (3) Five Wishes. Control subjects received standard care plus information.Statement of treatment preferences and Decisional Conflict Scale score.The mean age of the adolescents was 16 years; 36 (60%) were male, 30 (50%) white, 26 (43%) black, and 4 (7%) Asian. Diagnoses were as follows: leukemia (14 patients [47%]), brain tumor (8 [27%]), solid tumor (6 [20%]), and lymphoma (2 [7%]). Significantly increased congruence was observed for intervention dyads compared with controls for 4 of the 6 disease-specific scenarios; for example, for situation 2 ("treatment would extend my life by not more than 2 to 3 months"), intervention dyads demonstrated higher congruence (κ = 0.660; P < .001) vs control dyads (κ = -0.0636; P = .70). Intervention adolescents (100%) wanted their families to do what is best at the time, whereas fewer control adolescents (62%) gave families this leeway. Intervention adolescents were significantly better informed about end-of-life decisions (t = 2.93; effect size, 0.961; 95% CI, 0.742-1.180; P = .007). Intervention families were more likely to concur on limiting treatments than controls. An ethnic difference was found in only one situation.Advance care planning enabled families to understand and honor their adolescents' wishes. Intervention dyads were more likely than controls to limit treatments. Underserved African American families were willing to participate.
Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor
Authors: Y. Shiraishi, K. Asano, T. Nakajima, K. Niimi, Y. Suzuki, T. Shiomi, K. Sayama, T. Oguma, E. Ikeda, H. Hirai, K. Yamaguchi, A. Ishizaka
Journal: Journal of Allergy and Clinical Immunology (2005)
Estimating the Economic Costs of Alcohol Abuse
Authors: Ralph E. Berry
Journal: New England Journal of Medicine (1976)

There is general awareness that alcohol abuse is one of the nation's most serious public-health problems. Until recently, the view that alcoholism reflects an individual moral weakness or failing dominated society's attitudes and policy towards the problem. Still somewhat common, this judgment is nevertheless yielding to the recognition of alcoholism as a disease and to more enlightened social policy. In 1970 Congress created the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to formulate policy and goals for the prevention, control, and treatment of alcohol abuse and alcoholism.The NIAAA recognized that in a benefit/cost context, reductions in specific economic . . .
Structure-specific inhibition by bile acids of adenosine triphosphate—dependent taurocholate transport in rat canalicular membrane vesicles
Authors: Toshirou Nishida, Mingxin Che, Zenaida Gatmaitan, Irwin M. Arias
Journal: Hepatology (1995)

The adenosine triphosphate (ATP)-dependent transport system is a major determinant of canalicular bile acid secretion. The system transports bile acids and neither organic cations nor non-bile acid organic anions, such as glucuronides or glutathione adducts. To define the structural specificity of the ATP-dependent system, the authors examined the ability of various bile acids to inhibit ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles. Only bile acids with a negative charge inhibited transport, which was unaffected by side chain length. Conjugated, but not unconjugated, mono- and di-hydroxy bile acids inhibited transport. The presence of 7 alpha- and 12 alpha-hydroxylation also influenced inhibition of ATP-dependent taurocholate transport. Inhibition of transport by bile acids was kinetically competitive. These results suggest that the canalicular ATP-dependent bile acid transport system depends on bile acid side chain charge, conjugation, and hydroxylation.
TEACHING THE PRINCIPLES OF SURGERY
Authors: MARTIN B. TINKER
Journal: JAMA (1910)

The surgical practice of twenty-five years hence will be what the surgeons of to-day make it, but the teachers of our medical schools cannot accomplish needed reforms until the members of the profession as a whole recognize the importance of such changes and give their support. When we consider the conditions in medical education twenty years ago—no preliminary requirements for medical study, a two years' course and little clinical and laboratory teaching—we realize how much has been accomplished. The higher place of the profession in public regard, better medical care for our own families and friends, larger fees, with the increased comfort and pleasure in living that they bring, have resulted from the efforts of the veteran leaders in the profession of to-day. These changes have not been brought about in a day, but are the result of long-continued and united effort. There is no possibility of standing still; we
Comment on: Cryer. Severe Hypoglycemia Predicts Mortality in Diabetes. Diabetes Care 2012;35:1814–1816
Authors: Wolfgang Kerner, Henry Völzke
Journal: Diabetes Care (2013)

In a commentary by Cryer (1), we came across his statement that “it is sobering to think that as many as 1 in 25—or even 1 in 10—patients with type 1 diabetes will die of iatrogenic hypoglycemia.” We have seen several thousands of patients with type 1 diabetes, but we can remember only very few patients who have died of hypoglycemia. …
A composite genomic profile of lung cancer in smokers and nonsmokers
Authors: Naftali Kaminski, David Pilzer, Gady Cojocaru, Ofer Margalit, Nir Friedman, Shlomit Reinstein, David Simansky, Penina Yaron, Amariglio Ninnete, Alon Yellin, Gideon Rechavi, Eitan Friedman, Meir Krupsky
Journal: Nature Genetics (2001)
Immunoradioactive agent against cancer.
Authors: T. Ghose, M. Cerini, M. Carter, R. C. Nairn
Journal: BMJ (1967)

Dextromoramide-Seymour-Shove and Wilson Ml for non-therapeutic reasons is recognized to be of increasing importance among younger people in Britain (Connell, 1964; Bewley, 1965).Dependence on an extensive range of other drugs is also becoming more common (Wilson, 1965 ; Madden and Wilson, 1966).This alarming increase in non-therapeutically-induced dependence must not be allowed to with- draw attention from the possibility of causing dependence in patients as a result of unwise or ignorant prescription of dependence-producing drugs for therapeutic reasons. SummaryTwo cases showing the features of dependence on dextromor- amide are described.Dependence had been produced in both patients after dextromoramide administration for relatively slight and temporary pain.On admission to hospital they were taking dextromoramide in doses of 15 mg.six-hourly and 20 mg. at one-hourly intervals.The diagnosis was confirmed in both cases by production of the abstinence syndrome by substitution of dummy tablets for dextromoramide under double-blind conditions, and in one case by the administration of nalorphine.The abstinence syndrome was more severe, but occurred later, after the administration of the dummy tablets.The possibility that the features of the abstinence syndrome can lead to misdiagnosis is discussed and the importance of recognizing therapeutically induced drug dependence in hospital is stressed.We should like to express our thanks to Dr. J. S. Madden, consultant psychiatrist in charge of the addiction unit at Moston Hospital, for his interest, and to the nursing staff in the unit for their assistance and co-operation in those investigations.We also wish to thank M.
Injection Therapy of Bleeding Peptic Ulcer. A Prospective, Randomized Trial using Epinephrine and Thrombin
Authors: J. Balanzó, C. Villanueva, S. Sainz, J. C. Espinós, C. Mendez, C. Guarner, F. Vilardell
Journal: Endoscopy (1990)

A prospective randomized trial involving 64 patients with bleeding peptic ulcers was performed to assess the efficacy of two modalities of injection therapy. The inclusion criterion was the presence of active bleeding or a visible vessel at emergency endoscopy. Thirty-two patients were treated with epinephrine (Group A) and 32 with epinephrine plus thrombin (Group B). Permanent hemostasis was achieved in 81.3 % Group A, and 84.4 % Group B patients, and therapy failures occurred in 18.6 % and 15.6 %, respectively. Mortality was nil in both groups. There were no differences in the requirement for emergency surgery, or in the number of transfusions in the two groups. A second elective endoscopy was performed in 49 patients between the 3rd and the 5th day after admission, proceeding to a second injection therapy if a visible vessel was still seen. There were no failures among re-injected patients. With one exception, none of the failures occurred in patients in whom a second endoscopy was done. Our results suggest that injection therapy, which is a simple technique, should be considered as the initial treatment of choice in bleeding peptic ulcer. The addition of thrombin to epinephrine does not improve the results of the method. An early second endoscopy and local therapy if a visible vessel is still present, may further improve the results.
A Clinical Guide to Epileptic Syndromes and Their Treatment
Authors: George L. Morris
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"STUDIES OF ROENTGENOGRAMS OF THE ACCESSORY NASAL SINUSES"-Reply
Authors: Max Unger
Journal: JAMA (1918)

corresponding improvement in the clinical symptoms or there was a rapid progression out into the lung structure with the development, as a rule, of a bronchopneumonia.In a few instances, the pneumonia was lobar, being con- fined to one or more lobes.In some cases the infection was
Privileged Communication After Death
Authors: Joseph E. Lifschutz
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The EDITORIAL on Beethoven's deafness (<b>217</b>:1697, 1971) prompts the following comment. Curiosity concerning great men is inevitable, but knowing about their personal idiosyncracies and ailments adds nothing to an understanding of their art. All of us, I believe, hope that the evils we have done will be interred with our bones. Certainly great men deserve no less than ordinary men. In this regard, many psychiatrists recently have been deeply disturbed by the release and publication of psychotherapeutic material by one of their number. The material is a series of drawings by the late Jackson Pollock, drawn specifically for his psychotherapy for severe emotional illness. The communications via drawings are as much a part of the psychotherapy as if they were verbatim notes of the sessions. Psychiatrists, indeed all physicians, owe their patients the assurance that death will not bring the indiscriminate publication of their medical or
Effect of new dopamine-blocking agent (oxiperomide) on drug-induced dyskinesias in Parkinson's disease and spontaneous dyskinesias.
Authors: P Bedard, J D Parkes, C D Marsden
Journal: BMJ (1978)

Oxiperomide, a new dopamine-receptor antagonist, was found to decrease dyskinesias in patients with Parkinson9s disease receiving levodopa or other dopamine agonists without necessarily increasing Parkinsonian symptoms. Oxiperomide also decreased spontaneous dyskinesias in those with tics and chorea and to a less extent in those with torsion dystonia, without necessarily causing Parkinsonism. These results provide evidence that more than one population of dopamine receptors exist in the extra pyramidal system, and encourage the search for selective dopamine antagonists.
Utilization Review Committees: Statement of the Problem
Authors: John M. Rumsey
Journal: JAMA (1966)

As recently as 30 years ago, there was little concern with whether hospitals were being used effectively. The overall admission rate was 59 per 1,000 persons. But great changes in the system of medical care, gradually evolving medical science, changes in public attitudes, development of prepayment mechanisms, and other factors have combined to change this. Last year the admission rate to short-term general hospitals was 135.8 per 1,000. Although the vast hospital construction program that followed World War II had laced the nation with a network of hospitals and expanded the bed supply significantly, the increased demand for hospital care more than kept pace. In 1953, the occupancy rate for nonfederal, short-term general hospitals was 72%. By 1964, it had risen more than four percentage points to 76.3%, even though 500 hospitals and almost 175,000 beds had been added in the interim. To a degree, averages are myths. The reported
Carbon Monoxide Production Associated with Ineffective Erythropoiesis*
Authors: Peter White, Ronald F. Coburn, William J. Williams, Manfred I. Goldwein, Mary L. Rother, Brenda C. Shafer
Journal: Journal of Clinical Investigation (1967)

The rate of endogenous carbon monoxide production ( Vco), determined by the closed rebreathing system technique, was elevated above the normal range in four of five patients studied with ineffective erythropoiesis (four patients with primary refractory anemia, one with thalassemia). The mean molar ratio of Vco to Vheme (rate of circulating heme catabolism, determined from (51)Cr red cell survival curves) was 3.0 +/- 0.6 (SE), indicating that most of the CO originated from sources other than circulating erythrocyte hemoglobin, in contrast to previous findings in patients with hemolytic anemia, where Vco paralleled Vheme closely.After administration of glycine-2-(14)C to these patients, endogenous CO was isolated by washout of body CO stores at high pO(2) or by reacting peripheral venous blood samples with ferricyanide. The CO was then oxidized to CO(2) by palladium chloride and trapped for counting in a liquid scintillation spectrometer. "Early labeled" peaks of (14)CO were demonstrated which paralleled "early labeled" peaks of stercobilin and preceded maximal labeling of circulating heme. Production of "early labeled" (14)CO in patients with ineffective erythropoiesis was greatly increased, up to 14 times that found in a normal subject. The increased Vco and "early (14)CO" production shown by these patients are presumably related mainly to heme catabolism in the marrow. The possibility exists that hepatic heme and porphyrin compounds may also contribute significantly to Vco, as suggested by the finding of a high Vco in an additional patient with porphyria cutanea tarda.
Dysfunctional Adiposity and the Risk of Prediabetes and Type 2 Diabetes in Obese Adults
Authors: Ian J. Neeland, Aslan T. Turer, Colby R. Ayers, Tiffany M. Powell-Wiley, Gloria L. Vega, Ramin Farzaneh-Far, Scott M. Grundy, Amit Khera, Darren K. McGuire, James A. de Lemos
Journal: JAMA (2012)

THEprevalence of overweight and obesity 1 has contributed to a doubling in type 2 diabetes mellitus incidence over the past 3 decades. 2Increasing rates of diabetes among obese individuals has counterbalanced reductions in other cardiovascular disease (CVD) risk factors and is the primary factor contributing to a slowed decline in CVD event rates in the general population. 3Prediabetes, an intermediate hyperglycemia phenotype and risk factor for diabetes, 4 is also associated with obesity and carries an excess risk for CVD and death. 5lthough increased body mass index (BMI) is associated with diabetes at the population level, 6 it does not adequately discriminate diabetes risk among obese individuals. 7Indeed, many obese persons appear resistant to the development of metabolic disease. 8Because the metabolic disease risks associated with obesity are heterogeneous, there remains an unmet clinical need for tools that differentiate obese persons who will ultimately develop prediabetes and diabetes from those who will remain metabolically healthy.Adipose tissue dysfunction is characterized by ectopic fat deposition in the abdominal viscera and liver, inflammatory and adipokine dysregulation, and insulin resistance and may be a more important mediator of diabetes devel-
A Different Point of View on Sex and Risk of Hip Implant Failure and Failure Rate in Women—Reply
Authors: Maria C. S. Inacio, Elizabeth W. Paxton, Art Sedrakyan
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Rationing Intensive Care
Authors: Robert Baker
Journal: JAMA (1994)

<h3>To the Editor.</h3> —We applaud the Society of Critical Care Medicine Ethics Committee<sup>1</sup>for developing a consensus statement that forthrightly recognizes medical triage<sup>2</sup>as the principle of rationing appropriate to critical care admission and discharge decisions. Although we generally concur with the committee, we note one omission and one inconsistency in their consensus statement. The committee properly asserts that triage decisions "must be made explicitly, fairly, and justly," and that "ethnic origin, race, sex, creed, social worth, and ability to pay should never be factors in determining triage decisions." Conspicuously absent from this list is "chronological age." The absence is conspicuous because Norman Daniels<sup>3</sup>and others have been arguing that chronological age in itself (not merely as a prognostic indicator) is a sufficient reason for denying access to advanced medical technology. Failing to list chronological age as discriminatory opens the door to age rationing. We appreciate the
DIATHERMY IN JOINT INJURIES
Authors: F. W. EWERHARDT
Journal: JAMA (1925)

Our subject matter being diathermy, by which is meant  through, it will not, perhaps, be amiss to discuss first the more generally known forms of heat so that we may better understand and appreciate the distinct differences of effect produced by these various modes of heating human tissue.  We speak of heat as being conductive, convective and conversive. Conduction is that form of heat which is conveyed to the body by virtue of direct contact with a superheated substance. It is the old-fashioned household method of applying heat whenever that therapy seemed to be indicated. As examples of this form we make mention of the hot water bottle, hot poultices, fomentations, electric pads and hot baths. These appliances transmit heat to the part with which they come in contact by fact of contiguity. Convective heat radiates from a source approximating, but not in contact with, the body. Thus the
Testing for Drugs-Reply
Authors: Arthur J. McBay
Journal: JAMA (1986)

<h3>In Reply.—</h3> Dr Alonso states that my opposition to drug testing as expressed by me in various journals is well known to forensic scientists. I have been actively involved in drug testing for over 30 years as a forensic toxicologist. I have supported and will continue to support properly conducted drug testing. I will continue to be critical of any drug testing that in my opinion is improperly conducted and improperly interpreted. I am not aware whether anything I have said or written applies to the analysis of drugs by the Georgia Bureau of Investigation or any other laboratory in the state of Georgia. The majority of people arrested for driving under the influence have alcohol alone or together with one or more of the large number of drugs included in Dr Alonso's second reference.<sup>1</sup>Impaired drivers should be removed from the highways, legally, whatever the reason. The statement