Myopathy Associated with Human Immunodeficiency Virus (HIV) but not with Zidovudine
Authors: David M. Simpson
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 November 1988Myopathy Associated with Human Immunodeficiency Virus (HIV) but not with ZidovudineDavid M. Simpson, MDDavid M. Simpson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-10-842 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Primary muscle disease is not commonly associated with human immunodeficiency virus (HIV) infection. Anecdotal reports (1) have raised concern about an association between zidovudine therapy and the occurrence of myopathy; these reports have prompted some clinicians to halt this therapy when muscle weakness occurs. From our experience with this disorder, we believe that this approach may be unwarranted.Since reporting our first case (2) of polymyositis associated with the acquired immunodeficiency syndrome (AIDS) in 1983, we (3) and other researchers (4, 5) have seen patients with myopathy as a distinct complication of HIV infection. Features of this...References1. Bessen L, Greene J, Louie E, Seitzman P, and Weinberg H. Severe polymyositis-like syndrome associated with zidovudine therapy of AIDS and ARC. N Engl J Med. 1988;318:708. CrossrefMedlineGoogle Scholar2. Snider W, Simpson D, Nielsen S, Gold J, Metroka C, and Posphasic ner J. Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients. Ann Neurol. 1983;14:403-18. CrossrefMedlineGoogle Scholar3. Simpson D and Bender A. Human immunodeficiency virus-associated myopathy: analysis of 11 patients. Ann Neurol. 1988;24:79-84. CrossrefMedlineGoogle Scholar4. Dalakas M and Pezeshkpour G. Neuromuscular diseases associated with human immunodeficiency virus infection. Ann Neurol. 1988;23(Suppl):S38-48. CrossrefMedlineGoogle Scholar5. Gonzales M, Olney R, and So Y. Subacute structural myopathy associated with human immunodeficiency virus infection. Arch Neurol. 1988;45:585-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: David M. Simpson, MDAffiliations: Mount Sinai Medical Center New York, NY 10029 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMuscle Toxicity of Drugs: When Drugs Turn Physiology into PathophysiologyImmune-Mediated Necrotizing Myopathy: Update on Diagnosis and ManagementNecrotizing MyopathiesThe changing spectrum of rheumatic disease in human immunodeficiency virus infectionNeurological Complications of HIV Infection and AIDSRehabilitation in joint and connective tissue diseases. 1. Systemic diseasesRetroviruses and Their Roles in Chronic Inflammatory Diseases and AutoimmunityMyopathy in HIV infection: the role of zidovudine and the significance of tubuloreticular inclusionsAspects électromyographiques, histoenzymologiques et immunocytochimiques dans les atteintes musculaires au cours de l'infection par le VIH. À propos de cinq observationsKortikosteroide und AIDSConcurrent zidovudine-induced myopathy and hepatoxicity in patients treated for human immunodeficiency virus (HIV) infectionUltrastructural characteristics and DNA immunocytochemistry in human immunodeficiency virus and zidovudine-associated myopathiesAids e miopatia relato de um caso e revisão da literaturaRheumatic manifestations in 556 patients with human immunodeficiency virus infectionZidovudine myopathy: A distinctive disorder associated with mitochondrial dysfunctionCharacteristics and Pathogenesis of Myositis in Human Immunodeficiency Virus Infection—Distinction from Azidothymidine-lnduced MyopathyMyopathy with Human Immunodeficiency Virus Type 1 (HIV-1) Infection: HIV-1 or Zidovudine?Michele Till, MD, Keith B. MacDonell, MDMitochondrial Myopathy Caused by Long-Term Zidovudine TherapyZidovudine-associated myopathyThe reply 15 November 1988Volume 109, Issue 10Page: 842-842KeywordsAIDSHIVHIV infectionsMusclesPolymyositis ePublished: 1 December 2008 Issue Published: 15 November 1988 PDF downloadLoading ...