tbuckley/cabot-search huggingface dataset:
Cervical Cancer Screening Intervals, 2006 to 2009: Moving Beyond Annual Testing
Authors: Zahava Berkowitz, Mona Saraiya, George F. Sawaya
Journal: JAMA Internal Medicine (2013)

Swimming Upstream: Doing Less in Health Care Is Hard: Comment on "No Papanicolaou Tests in Women Younger Than 21 Years or After Hysterectomy for Benign Disease" and "Cervical Cancer Screening Intervals, 2006 to 2009"
ICOVIR-5 Shows E2F1 Addiction and Potent Antiglioma Effect <i>In vivo</i>
Authors: Marta M. Alonso, Manel Cascallo, Candelaria Gomez-Manzano, Hong Jiang, B. Nebiyou Bekele, Anna Perez-Gimenez, Frederick F. Lang, Yuji Piao, Ramon Alemany, Juan Fueyo
Journal: Cancer Research (2007)

Abstract During 2007, ∼200,000 people in the United States will be diagnosed with brain tumors. Gliomas account for 77% of primary malignant brain tumors, and the prognosis has hardly changed in the past 20 years, with only 30% of patients with malignant glioma surviving 5 years after diagnosis. Oncolytic adenoviruses are promising therapies for the treatment of gliomas. Here, report the antiglioma activity of the tumor-selective ICOVIR-5 adenovirus, which encompasses an early 1A adenoviral (E1A) deletion in the retinoblastoma (Rb) protein-binding region, substitution of the E1A promoter for E2F-responsive elements, and an RGD-4C peptide motif inserted into the adenoviral fiber to enhance adenoviral tropism. Mechanistic studies showed a dramatic addiction of ICOVIR-5 to the E2F1 oncogene in vitro and in vivo. This addiction was mediated by the occupancy of the ectopic adenoviral E2F1-responsive elements by the endogenous E2F1 protein resulting in high level of E1A expression in cancer cells and potent antiglioma effect. Importantly, we showed for the first time the ability of oncolytic adenoviruses to enhance E2F transcriptional activity in vivo, and we provided direct evidence of the interaction of the E2F1 protein with native and ectopic adenovirus promoters. Restoration of Rb function led to the association of Rb/E2F1 repressor complexes with ICOVIR-5 ectopic E2F1 promoter and subsequent down-modulation of E1A, dramatically impairing adenoviral replication. In xenografted mice, intratumoral injection of ICOVIR-5 resulted in a significant improvement of the median survival (P &amp;lt; 0.0001), and furthermore, led to 37% of long-term survivors free of disease. The antitumor activity of ICOVIR-5 suggests that it has the potential to be an effective agent in the treatment of gliomas. [Cancer Res 2007;67(17):8255–63]
The Scientific Basis for Coverage Decisions by Third-Party Payers
Authors: O. B. Towery
Journal: JAMA (1981)

Each third-party health payer has its own method of determining which medical services should be covered. The new National Center for Health Care Technology (NCHCT) is charged with evaluating the medical and scientific basis for Medicare coverage of various tests and procedures used in the practice of medicine. Many of the important issues involved in performing these evaluations and the NCHCT approach are described in this article. (<i>JAMA</i>1981;245:59-61)
Nuclear Medicine in Clinical Diagnosis and Treatment
Authors: J. Reeve
Journal: BMJ (1995)

Ed I P C Murray, P J Ell Churchill Livingstone, pounds sterling195, pp 1388 (2 vols) ISBN 0 443 04710 3

In 1948, five years after he won the Nobel prize for his pioneering use of radioisotopes in the life sciences, George Hevesy wondered whether his survey of the field in Radioactive Indicators would be the last.

He need not have worried. Ten years later came Veall and Vetter's Radioisotope Techniques in Clinical Research and Diagnosis. The term nuclear medicine had still to be invented, but one of the first textbook descriptions …
Myxedema coma and cardiac arrest
Authors: W. J. Georgitis
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Bacci et al reported a case of cardiac arrest in a 63-year-old woman 15 minutes after an intravenous dose of 300 μg of levothyroxine (1981;245:920). They considered one possible mechanism for the cardiac standstill to be a direct effect of levothyroxine on cardiac cellular metabolism. The authors essentially invited similar case reports with the suggestion that more such reports might necessitate reconsideration of current recommendations for levothyroxine therapy in myxedema coma. The patient was reported to have had blood gas values on room air and on nasal oxygen at 2 L/min that showed hypoxemia and hypercarbia with mild acidosis. No reference was made to the time relationships between the arterial blood gas measurements, duration of oxygen therapy, and the episode of cardiac standstill. It is possible that more severe respiratory acidosis developed in the patient as a result of oxygen administration without assisted mechanical ventilatory support. This
Unusual Osseous Metastases of Hepatoma
Authors: Elliot J. Reichbach
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pustular psoriasis-like lesions associated with hereditary lactate dehydrogenase M subunit deficiency without interleukin-36 receptor antagonist mutation: long-term follow-up of two cases
Authors: T. Ito, M. Aoshima, K. Sugiura, T. Fujiyama, N. Ito, J.I. Sakabe, M. Akiyama, M. Maekawa, Y. Tokura
Journal: British Journal of Dermatology (2015)

Journal Article Pustular psoriasis‐like lesions associated with hereditary lactate dehydrogenase M subunit deficiency without interleukin‐36 receptor antagonist mutation: long‐term follow‐up of two cases Get access T. Ito, T. Ito Department of Dermatology Hamamatsu University School of Medicine 1‐20‐1 Handayama Higashi‐ku Hamamatsu 431‐3192 Japan E‐mail: itoutai@hama-med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Aoshima, M. Aoshima Department of Dermatology Hamamatsu University School of Medicine 1‐20‐1 Handayama Higashi‐ku Hamamatsu 431‐3192 Japan Search for other works by this author on: Oxford Academic Google Scholar K. Sugiura, K. Sugiura Department of Dermatology Nagoya University Graduate School of Medicine Nagoya Japan Search for other works by this author on: Oxford Academic Google Scholar T. Fujiyama, T. Fujiyama Department of Dermatology Hamamatsu University School of Medicine 1‐20‐1 Handayama Higashi‐ku Hamamatsu 431‐3192 Japan Search for other works by this author on: Oxford Academic Google Scholar N. Ito, N. Ito Department of Dermatology Hamamatsu University School of Medicine 1‐20‐1 Handayama Higashi‐ku Hamamatsu 431‐3192 Japan Search for other works by this author on: Oxford Academic Google Scholar J.I. Sakabe, J.I. Sakabe Department of Dermatology Hamamatsu University School of Medicine 1‐20‐1 Handayama Higashi‐ku Hamamatsu 431‐3192 Japan Search for other works by this author on: Oxford Academic Google Scholar M. Akiyama, M. Akiyama Department of Dermatology Nagoya University Graduate School of Medicine Nagoya Japan Search for other works by this author on: Oxford Academic Google Scholar M. Maekawa, M. Maekawa Department of Laboratory Medicine Hamamatsu University School of Medicine 1‐20‐1 Handayama Higashi‐ku Hamamatsu 431‐3192 Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Tokura Y. Tokura Department of Dermatology Hamamatsu University School of Medicine 1‐20‐1 Handayama Higashi‐ku Hamamatsu 431‐3192 Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 6, 1 June 2015, Pages 1674–1676, https://doi.org/10.1111/bjd.13590 Published: 01 June 2015
Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production
Authors: Christopher J. Hall, Rachel H. Boyle, Jonathan W. Astin, Maria Vega Flores, Stefan H. Oehlers, Leslie E. Sanderson, Felix Ellett, Graham J. Lieschke, Kathryn E. Crosier, Philip S. Crosier
Journal: Cell Metabolism (2013)
STUDIES WITH RADIOACTIVE IODIZED FAT. II. THE TISSUE DISTRIBUTION OF EMULSIFIED FAT FOLLOWING INTRAVENOUS ADMINISTRATION 1
Authors: Alexander M. Rutenburg, Arnold M. Seligman, Jacob Fine
Journal: Journal of Clinical Investigation (1949)

Expressed in per cent of total radioactivity injected.Muscle assumed to be 30% of body weight (23).All other organs weighed wet.t Radioactivity of 1 gm.tissue, expressed in per cent of the radioactivity circulating at zero time in 1 cc.plasma, assuming plasma volume to be 5% of total body weight.
Advice on ganglions is flawed
Authors: Peter J Mahaffey
Journal: BMJ (2004)

EDITOR—The POEM headline “Half of all ganglions resolve spontaneously” is likely to lead to dangerous conclusions about a common hand condition among casual readers.1 The text discusses a form of ganglion that constitutes only 18-20% of all such lesions, which is not made clear in the bottom line.

This POEM draws on the evidence of …
Difficult to treat asthma in adults
Authors: G. P Currie, J G. Douglas, L. G Heaney
Journal: BMJ (2009)

#### Summary points

There is no universally accepted definition of difficult asthma. However, it is reasonable to consider it present when people have persistent symptoms and frequent exacerbations, despite being treated at steps 4 or 5 of the British Thoracic Society and Scottish Intercollegiate Guideline Network (BTS/SIGN) guidelines (fig 1⇓).1 Such patients typically receive high dose inhaled steroids (≥800 µg beclometasone equivalent), a long acting β2 agonist, plus add-on treatment. The prevalence of difficult asthma is uncertain, but it may account for 5-10% of adults with asthma.2 Morbidity and health costs are disproportionately high in these patients,w1 and they are at greater risk of fatal and near fatal exacerbations.w2 In addition, frequent, intermittent, or continuous courses of oral prednisolone (plus regular high dose inhaled steroids) increase the risk of steroid related adverse effects.

#### Sources and selection criteria

All authors performed a comprehensive search of articles published up to January 2009 using PubMed and Medline. Keywords and phrases used were “asthma”, “exacerbations”, “symptoms”, “difficult asthma”, “lung function”, “diagnosis”, “bronchial hyper-responsiveness”, “nitric oxide”, “sputum eosinophils”, “treatment”, “monitoring”, “inhaled steroids”, “long acting β2 agonists”, “leukotriene receptor antagonists”, “bronchial thermoplasty”, “immunoglobulin E therapy”, and “tumour necrosis factor”.



Fig 1 Simplified diagram of the pharmacological management of chronic asthma in adults1 w1



Several key questions must be considered before prescribing add-on treatments and higher …
Hematopoiesis in the Grey Collic Dog STUDIES OF THE REGULATION OF ERYTHROPOIESIS
Authors: John W. Adamson, David C. Dale, Ronald J. Elin
Journal: Journal of Clinical Investigation (1974)

Hematopoiesis in the grey collie dog undergoes periodic fluctuations which involve reticulocytes, granulocytes, platelets, lymphocytes, and monocytes. This syndrome is inherited in an autosomal recessive manner and can be transmitted or abolished by appropriate bone marrow transplantation experiments, thus demonstrating this to be a primary marrow defect. Investigation of humoral regulation in this setting indicates that serum erythropoietin (ESF) also undergoes cyclic fluctuation and that shortly after the increase and peak in serum ESF levels recognizable red cell precursors appear in the marrow. Erythropoiesis in the grey collie is reciprocally related to the blood O2 carrying capacity. With phlebotomy, ESF activity and reticulocytes increase but continue to cycle, while hypertransfusion eliminates reticulocyte production completely. Neither phlebotomy nor hypertransfusion alter the underlying cycle time (11-12 days) nor influence the peaks of peripheral blood granulocytes. Thus, in these experiments, no direct evidence of competition between reticulocyte and granulocyte production is observed. In vitro studies of canine hemoglobin synthesis fail to demonstrate evidence of an inhibitor to ESF. These results indicate that periodic fluctuation of serum ESF is an integral part of the grey collie syndrome and are most consistent with some form of feedback regulation of ESF production.
The Value of Scintigraphy in the Evaluation of a Wandering Spleen
Authors: DAVID GROSHAR, ORA ISRAEL, AMI BARZILAI, DOV FRONT
Journal: Clinical Nuclear Medicine (1986)

The scintigraphic diagnosis of wandering spleen is discussed. Clinical, ultrasonographic, and CT findings were nonconclusive; however, liver-spleen scan using labeled colloid led to the specific diagnosis.
Hormonal status of postmenopausal women with alcohol-induced cirrhosis: Further findings and a review of the literature
Authors: Judith S. Gavaler, David H. van Thiel
Journal: Hepatology (1992)

The derangements of levels of sex hormones and gonadotropins in alcoholic cirrhotic men are well delineated. The countersituation in alcoholic cirrhotic women has not yet been fully described. This study was performed in postmenopausal women among whom menstrual cycle variations in hormones no longer occur; with such a study population, it is possible to control for confounding factors and thus optimize detection of differences in levels of hormones and hormone interrelationships. Both estradiol levels and a rough estimate of aromatization of testosterone to estradiol, the estradiol to testosterone ratio, were significantly elevated in the 20 alcoholic subjects with alcohol-induced cirrhosis, as compared with the 27 normal controls; similarly, testosterone, luteinizing hormone and follicle-stimulating hormone were all significantly reduced in the alcoholic cirrhotic women. In addition, the normal relationships of estradiol with luteinizing hormone, follicle-stimulating hormone, body mass and the estradiol/testosterone ratio were detected in the control group but not in the group of cirrhotic women. Further, among the alcoholic cirrhotic postmenopausal women, testosterone, luteinizing hormone, follicle-stimulating hormone and the estradiol/testosterone ratio were all significantly correlated with the Child's liver disease severity score. That the hormone levels and their interrelationships differ markedly between normal and alcoholic cirrhotic women extends previous findings in both men and postmenopausal women; the correlations of hormone levels and markers of liver disease will require further investigation.
How psychiatrists can play their part in the tsunami relief effort
Authors: Bob Adams
Journal: BMJ (2005)

I was on holiday with my wife and son at a hotel on the west coast of Sri Lanka when the tsunami struck. It was 10 am, Boxing Day. Only afterwards did we realise how lucky we were to get away unscathed. At the time we were on the third floor of our hotel watching and videotaping the staff clearing up the mess from an initial, small wave. We could have no perception of what would happen next. Two days later our recording of the wave appearing through the trees, crossing the pool, and hitting the hotel was shown on worldwide television before more spectacular films superseded it. My wife's nursing skills were immediately put to good use in the hotel lobby, where she dressed and cleaned wounds with the hotel staff, a casualty senior house officer, and a dentist with a suture kit. There was little for a psychiatrist to do at this time. …
Stress-induced and sympathetically-mediated electrocardiographic and circulatory variations in the primary hyperkinetic heart syndrome
Authors: M. GUAZZI, C. FIORENTINI, A. POLESE, F. MAGRINI, M. T. OLIVARI
Journal: Cardiovascular Research (1975)

As shown by the inotropic changes, the sympathetic discharge on the heart, is selectit syndrome. In the steady state the electrocardiogram shows flat, diphasic, or "tucked' T waves. Mental stimulation or isoproterenol, and, respectively, pain or beta blockade induce changes of the repolarization phase divergent from steady state. The former causes ST depression and deep T-wave inversion and the latter fully normalizes the repolarization phase. It is concluded that the electrical activity of the heart is directly influenced by the adrenergic drive in this disorder, and that different stressful factors can alter the repolarization phase in opposite ways in relation to the influence of the stimulus on the cardiac sympathetic tone.
The Human Placenta
Authors: Arthur T. Hertig
Journal: JAMA (1970)

This magnificent treatise on the human placenta is a definitive work on the normal structure of that vital and often-neglected organ. The usual book, like a bottle of wine, is soon finished, leaving only more or less pleasant memories. This book, however, large in size and broad in scope, is more like a whole wine cellar—to be read and enjoyed over a long period of time. Indeed, its wealth of material requires careful, thoughtful, and unhurried reading. The contents are arranged in a logical developmental manner, beginning with "Historical Survey" and ending, 21 chapters later, with "The Placenta in Multiple Pregnancies." No facet of structure or function is neglected. The authors draw upon their exhaustive personal knowledge, their own significant material and a scholarly, orderly, and relevant review of the literature. More than 1,500 references are cited and analyzed. The authors are extraordinarily skillful in weaving the findings of a
DINITROPHENOL POISONING CAUSING JAUNDICE: REPORT OF CASE
Authors: Nathan Sidel
Journal: JAMA (1934)

Within the past year, dinitrophenol has been used extensively as a means of reducing weight. However, its possible harmful effects have not been realized sufficiently until very recently. In papers by Anderson, Reed and Emerson,<sup>1</sup>Geiger,<sup>2</sup>Poole and Haining,<sup>3</sup>and Tainter and Wood,<sup>4</sup>fatal results from the use of dinitrophenol have been reported. In all probability, a great many more poisonings and fatalities have occurred, since many druggists are dispensing dinitrophenol without a physician's prescription, under both the name of dinitrophenol and various proprietary names. A case of toxic hepatitis with intense jaundice following the use of dinitrophenol is here reported. <h3>REPORT OF CASE</h3> B. R., a white woman, unmarried, aged 26, had used various reducing diets because she weighed too much for her stature (58 inches, 145 cm.). The past history and family history were essentially negative. The patient began taking dinitrophenol, Feb. 18, 1934,
Privy Council reverses GMC decisions to strike off doctors
Authors: Clare Dyer
Journal: BMJ (2001)

Two UK doctors won rare rulings from the Privy Council last week quashing decisions by the General Medical Council to strike them off the medical register. Willem Bijl, a consultant urologist, was instead suspended for one year, and GP Mahmood Hossain will have conditions imposed on his right to practise.

Traditionally the Privy Council—the law lords sitting as the final court of appeal against GMC rulings—has been reluctant to interfere with the GMC's decisions. But since the advent of the Human Rights Act a year ago, which requires a …
Hydrops fetalis–associated congenital dyserythropoietic anemia treated with intrauterine transfusions and bone marrow transplantation
Authors: Angel F. Remacha, Isabel Badell, Núria Pujol-Moix, Juan Parra, Eduardo Muñiz-Diaz, Gemma Ginovart, M. Pilar Sardà, Angel Hernández, Elisenda Moliner, Montserrat Torrent
Journal: Blood (2002)
Rethinking established dogma. Is good general practice possible?
Authors: E Wilkes
Journal: BMJ (1984)

RNA-binding protein HuR (<i>ELAVL1</i>) is a master regulator of gene expression in human pathophysiology. Its dysregulation plays an important role in many diseases. We hypothesized that HuR plays an important role in Th2 inflammation in asthma in both mouse and human. To address this, we used a model of airway inflammation in a T cell–specific knockout mouse model, distal lck<i>-Cre</i> HuR<sup>fl/fl</sup>, as well as small molecule inhibitors in human peripheral blood-derived CD4<sup>+</sup> T cells. Peripheral CD4<sup>+</sup> T cells were isolated from 26 healthy control subjects and 45 asthmatics (36 type 2 high and 9 non–type 2 high, determined by blood eosinophil levels and fraction of exhaled NO). Our mouse data showed conditional ablation of HuR in T cell–abrogated Th2 differentiation, cytokine production, and lung inflammation. Studies using human T cells showed that HuR protein levels in CD4<sup>+</sup> T cells were significantly higher in asthmatics compared with healthy control subjects. The expression and secretion of Th2 cytokines were significantly higher in asthmatics compared with control subjects. AMP-activated protein kinase activator treatment reduced the expression of several cytokines in both type 2 high and non–type 2 high asthma groups. However, the effects of CMLD-2 (a HuR-specific inhibitor) were more specific to endotype-defining cytokines in type 2 high asthmatics. Taken together, these data suggest that HuR plays a permissive role in both allergen and non–allergen-driven airway inflammation by regulating key genes, and that interfering with its function may be a novel method of asthma treatment.