Hodgkin's Disease
Authors: SEYMOUR PERRY
Journal: Annals of Internal Medicine (1967)

Clinical Staff Conference1 August 1967Hodgkin's DiseaseCombined Clinical Staff Conference at the National Institutes of HealthSEYMOUR PERRY, M.D., F.A.C.P., LOUIS B. THOMAS, M.D., RALPH E. JOHNSON, M.D., PAUL P. CARBONE, M.D., HARLEY A. HAYNES, M.D.SEYMOUR PERRY, M.D., F.A.C.P.Search for more papers by this author, LOUIS B. THOMAS, M.D.Search for more papers by this author, RALPH E. JOHNSON, M.D.Search for more papers by this author, PAUL P. CARBONE, M.D.Search for more papers by this author, HARLEY A. HAYNES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-424 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Seymour Perry: It is interesting that through the years a few individuals have been brave enough to suggest that Hodgkin's disease might indeed be curable. In fact, Yates and Bunting (1) in 1915 were the first to mention the possibility of a cure and 2 years later wrote (2): "We are of the opinion that in about 20% of all cases as we see them, recovery is a possibility at present." "Earlier diagnosis and the recognition that Hodgkin's disease, if treated promptly and radically, is curable would raise this percentage materially . . ." (3).Then Dr. Vera Peters...References1. YATESBUNTING JLCH: The rational treatment of Hodgkin's disease. JAMA 64: 1953, 1915. CrossrefGoogle Scholar2. YATESBUNTING JLCH: Results of treatment of Hodgkin's disease. JAMA 68: 747, 1917. CrossrefGoogle Scholar3. KARNOFSKY DA: The staging of Hodgkin's disease. Cancer Res. 26: 1090, 1966. MedlineGoogle Scholar4. PETERSMIDDLEMISS MVKC: A study of Hodgkin's disease treated by irradiation. Amer. J. Roentgen. 79: 114, 1958. Google Scholar5. EASSONRUSSELL ECMH: The cure of Hodgkin's disease. Brit. Med. J. 1: 1704, 1963. CrossrefMedlineGoogle Scholar6. EASSON EC: Long-term results of radical radiotherapy in Hodgkin's disease. Cancer Res. 26: 1244, 1966. MedlineGoogle Scholar7. Symposium: Obstacles to the control of Hodgkin's disease. Ibid., p. 1045. Google Scholar8. AISENBERG AC: Hodgkin's disease—prognosis, treatment and etiologic and immunologic considerations. New Eng. J. Med. 270: 508, 1964. CrossrefMedlineGoogle Scholar9. Facts on the Major Killing and Crippling Diseases in the United States Today. The National Health Education Committee, Inc., New York, 1964. Google Scholar10. CRAVER LF: Hodgkin's disease, in Practice of Medicine, vol. 6, edited by TICE, F. K., HARVEY, J. C. W. F. Prior Co., Inc., Hagerstown, Md., 1964, p. 1017. Google Scholar11. EWING J: Neoplastic Diseases: A Treatise on Tumors, 4th ed. W. B. Saunders Co., Philadelphia, 1940. Google Scholar12. CRAFT CB: Results with roentgen ray therapy in Hodgkin's disease. Bull. Univ. Minn. Hosp. 11: 391, 1940. Google Scholar13. JACKSONPARKER HF: Hodgkin's Disease and Allied Disorders. Oxford University Press, Inc., New York, 1947. Google Scholar14. SHIMKINOPPERMANNBOSTICKLOW-BEER MBKCWLBV: Hodgkin's disease. Analysis of frequency distribution and mortality at the University of California Hospital, 1914-1951. Ann. Intern. Med. 42: 136, 1955. LinkGoogle Scholar15. THOMASFREIHILBISH LBETF: Regional considerations of leukemia and lymphoma: the skeletal system, in Treatment of Cancer and Allied Diseases, vol. IX, 2nd ed., edited by PACK, G. T., ARIEL, I. M. Hoeber Medical Division, Harper & Row, Inc., New York, 1964, chap. 9B. Google Scholar16. CASAZZADUVALLCARBONE ARCPPP: Summary of infectious complications occurring in patients with Hodgkin's disease. Cancer Res. 26: 1290, 1966. MedlineGoogle Scholar17. JACKSONPARKER HF: Hodgkin's disease. I. General considerations. New Eng. J. Med. 230: 1, 1944. CrossrefGoogle Scholar18. LUKESBUTLER RJJJ: The pathology and nomenclature of Hodgkin's disease. Cancer Res. 26: 1063, 1966. MedlineGoogle Scholar19. BROWNHAYNESFOLEYGODWINBERARDCARBONE RSHAHTHACWPP: Hodgkin's disease: immunologic, clinical, and histologic features of 50 untreated patients. Ann. Intern. Med. 67: 291, 1967. LinkGoogle Scholar20. MACMAHON B: Epidemiology of Hodgkin's disease. Cancer Res. 26: 1189, 1966. MedlineGoogle Scholar21. GILBERT R: Radiotherapy in Hodgkin's disease (malignant granulomatosis). Amer. J. Roentgen. 41: 198, 1939. Google Scholar22. EASSON EC: Cancer and the problem of pessimism. CA 17: 7, 1967. Google Scholar23. PETERS MV: The place of irradiation in the control of Hodgkin's disease. Proc. Nat. Cancer Conf. 4: 571, 1961. Google Scholar24. KAPLAN HS: The radical radiotherapy of regionally localized Hodgkin's disease. Radiology 78: 553, 1962. CrossrefMedlineGoogle Scholar25. NICESTENSTROM CMKW: Irradiation therapy in Hodgkin's disease. Radiology 62: 641, 1954. CrossrefMedlineGoogle Scholar26. JELLIFFETHOMSON AMAD: The prognosis in Hodgkin's disease. Brit. J. Cancer 9: 21, 1955. CrossrefMedlineGoogle Scholar27. SCOTT RM: Time-dose relationship in Hodgkin's disease. Radiology 76: 276, 1961. CrossrefMedlineGoogle Scholar28. NOETZLISHELINE MGE: Local recurrence in lymph nodes irradiated for Hodgkin's disease. Progr. Radiat. Ther. 2: 188, 1962. Google Scholar29. KAPLAN HS: Evidence for a tumoricidal dose level in the radiotherapy of Hodgkin's disease. Cancer Res. 26: 1221, 1966. MedlineGoogle Scholar30. VAETH JM: Retreatment of mediastinal Hodgkin's disease. Progr. Radiat. Ther. 2: 164, 1962. MedlineGoogle Scholar31. SHEER AC: The course of Stage I malignant lymphomas following local treatment. Amer. J. Roentgen. 90: 939, 1963. Google Scholar32. ROSENBERGKAPLAN SAHS: Evidence for an orderly progression in the spread of Hodgkin's disease. Cancer Res. 26: 1225, 1966. MedlineGoogle Scholar33. PETERS MV: Prophylactic treatment of adjacent areas in Hodgkin's disease. Ibid., p. 1232. Google Scholar34. KAPLANROSENBERG HSSA: Extended-field radical radiotherapy in advanced Hodgkin's disease: short-term results of 2 randomized clinical trials. Ibid., p. 1268. Google Scholar35. JOHNSONFOLEYSTECKELGLENN REHTRJDW: Extended radiotherapy in advanced Hodgkin's disease. Hematologic aspects. Arch. Intern. Med. (Chicago) 118: 70, 1966. CrossrefMedlineGoogle Scholar36. GLENNFAWKAGANJOHNSON DWFLARRE: Field separation in multiple portal radiation therapy. In preparation. Google Scholar37. SCOTT JL: The effect of nitrogen mustard and maintenance chlorambucil in the treatment of advanced Hodgkin's disease. Cancer Chemother. Rep. 27: 27, 1963. MedlineGoogle Scholar38. GOLDSALVINSHNIDER GLLGBI: A comparative study with three alkylating agents: mechlorethamine, cyclophosphamide, and uracil mustard. Cancer Chemother. Rep. 16: 417, 1962. MedlineGoogle Scholar39. SPURRCARBONESCHNEIDERMAN CLPPMA: Comparative evaluation of cyclophosphamide and vinca alkaloids in lymphomas (abstract). Proc. Amer. Ass. Cancer Res. 7: 67, 1966. Google Scholar40. HOLLANDREGELSONSELAWRYCOSTA JFWOSG: Methylglyoxal-bis-guanylhydrazone—an active agent against Hodgkin's disease and acute myeloblastic leukemia. Acta Un. Int. Cancr. 20: 352, 1964. MedlineGoogle Scholar41. MATHÉSCHWEISGUTHSCHNEIDERAMIELBERUMENBRULECATTANSCHWARZENBERG GOMJLLGAR: Methyl-hydrazine in treatment of Hodgkin's disease and various forms of haematosarcoma and leukemia. Lancet 2: 1077, 1963. CrossrefMedlineGoogle Scholar42. DEVITASERPICKCARBONE VTAPP: Preliminary clinical studies with ibenzmethyzin. Clin. Pharmacol. Ther. 7: 542, 1966. CrossrefMedlineGoogle Scholar43. HALL TC: New chemotherapeutic agents in Hodgkin's disease. Cancer Res. 26: 1297, 1966. MedlineGoogle Scholar44. MOOREDIPAOLOKONDO GEJAT: The chemotherapeutic effects and complications of Actinomycin D in patients with advanced cancer. Cancer 11: 1204, 1958. CrossrefMedlineGoogle Scholar45. HUMPHREYDIETRICH EWFS: Clinical experience with the methyl ester of streptonigrin (NSC 45384). Cancer Chemother. Rep. 33: 21, 1963. MedlineGoogle Scholar46. STUTZMANEZDINLISTUTZMAN LEZMA: Vinblastine sulfate vs cyclophosphamide in the therapy for lymphoma. JAMA 195: 173, 1966. CrossrefMedlineGoogle Scholar47. SKIPPERSCHABELWILCOX HEFMWS: Experimental evaluation of potential anti-cancer agents. XIII. On the criteria and kinetics associated with "curability" of experimental leukemia. Cancer Chemother. Rep. 35: 1, 1964. MedlineGoogle Scholar48. FREIDEVITAMOXLEYCARBONE EVTJHPP: Approaches to improving the chemotherapy of Hodgkin's disease. Cancer Res. 26: 1284, 1966. MedlineGoogle Scholar49. LACHERDURANT MJJR: Combined vinblastine and chlorambucil therapy of Hodgkin's disease. Ann. Intern. Med. 62: 468, 1965. LinkGoogle Scholar50. DEVITAMOXLEYBRACEFREI VTJHKCE: Intensive combination chemotherapy and X-irradiation in the treatment of Hodgkin's disease (abstract). Proc. Amer. Ass. Cancer Res. 6: 15, 1965. Google Scholar51. DEVITASERPICK VTA: Combination chemotherapy in the treatment of advanced Hodgkin's disease (abstract). Proc. Amer. Ass. Cancer Res. 8: 13, 1967. Google Scholar52. MILLER DG: Chemotherapy as a primary treatment of Hodgkin's disease. Cancer Res. 26: 1303, 1966. MedlineGoogle Scholar53. HANCOCKLEDLIE PEEM: Treatment of early Hodgkin's disease. Lancet 1: 26, 1967. CrossrefMedlineGoogle Scholar54. CHASE MW: Delayed-type hypersensitivity and the immunology of Hodgkin's disease, with a parallel examination of sarcoidosis. Cancer Res. 26: 1097, 1966. MedlineGoogle Scholar55. AISENBERG AC: Manifestations of immunologic unresponsiveness in Hodgkin's disease. Ibid., p. 1152. Google Scholar56. STEINER PE: Etiology of Hodgkin's disease. II. Skin reaction to avian and human tuberculin proteins in Hodgkin's disease. Arch. Intern. Med. (Chicago) 54: 11, 1934. CrossrefGoogle Scholar57. SCHIER WW: Cutaneous anergy and Hodgkin's disease. New Eng. J. Med. 250: 353, 1954. CrossrefMedlineGoogle Scholar58. KELLYGOODVARCO WDRARL: Anergy and skin homograft survival in Hodgkin's disease. Surg. Gynec. Obstet. 107: 565, 1958. MedlineGoogle Scholar59. KELLYLAMBVARCOGOOD WDDLRLRA: An investigation of Hodgkin's disease with respect to the problem of homotransplantation. Ann. N. Y. Acad. Sci. 87: 187, 1960. CrossrefMedlineGoogle Scholar60. LAMBPILNEYKELLYGOOD DFWDRA: A comparative study of the incidence of anergy in patients with carcinoma, leukemia, Hodgkin's disease and other lymphomas. J. Immun. 89: 555, 1962. MedlineGoogle Scholar61. ROTTINOHOFFMANN AGT: Studies of immunological reactions of patients with Hodgkin's disease: the tuberculin reaction. Amer. J. Med. Sci. 220: 662, 1950. CrossrefMedlineGoogle Scholar62. MILLERLIZARDOSNYDERMAN DGJGRK: Homologous and heterologous skin transplantation in patients with lymphomatous disease. J. Nat. Cancer Inst. 26: 569, 1961. MedlineGoogle Scholar63. AISENBERG AC: Studies of lymphocyte transfer reactions in Hodgkin's disease. J. Clin. Invest. 44: 555, 1965. CrossrefMedlineGoogle Scholar64. SOKALPRIMIKIRIOS JEN: The delayed skin test response in Hodgkin's disease and lymphosarcoma. Effect of disease activity. Cancer 14: 597, 1961. CrossrefGoogle Scholar65. EISENORRISBELMAN HNLS: Elicitation of delayed allergic skin reactions with haptens: the dependence of elicitation of hapten combination with protein. J. Exp. Med. 95: 473, 1952. CrossrefMedlineGoogle Scholar66. AISENBERG AC: Studies on delayed hypersensitivity in Hodgkin's disease. J. Clin. Invest. 41: 1964, 1962. CrossrefMedlineGoogle Scholar67. HERSHOPPENHEIM EMJJ: Impaired in vitro lymphocyte transformation in Hodgkin's disease. New Eng. J. Med. 273: 1006, 1965. CrossrefMedlineGoogle Scholar68. FAZIOCALCIATI MA: An attempt to transfer tuberculin hypersensitivity in Hodgkin's disease. Panminerva Med. 4: 164, 1962. MedlineGoogle Scholar69. WARWICKARCHERKELLYPAGE WJOWDAR: Anergy of delayed allergy in Hodgkin's disease patients (abstract). Fed. Proc. 20: 18, 1961. MedlineGoogle Scholar70. URBACHSONESISRAEL FMHL: Passive transfer of tuberculin sensitivity to patients with sarcoidosis. New Eng. J. Med. 247: 794, 1952. CrossrefMedlineGoogle Scholar71. WOODRUFFANDERSON MFNF: The effect of lymphoctye depletion by thoracic duct fistula and administration of antilymphocytic serum on the survival of skin homografts in rats. Ann. N. Y. Acad. Sci. 120: 119, 1964. CrossrefMedlineGoogle Scholar72. CASAZZADUVALLCARBONE ARCPPP: Infection in lymphoma. JAMA 197: 710, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SEYMOUR PERRY, M.D., F.A.C.P.; LOUIS B. THOMAS, M.D.; RALPH E. JOHNSON, M.D.; PAUL P. CARBONE, M.D.; HARLEY A. HAYNES, M.D.Affiliations: Bethesda, MarylandThis is an edited transcription of a Combined Clinical Staff Conference at the Clinical Center, Bethesda, Md., by the National Cancer Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.Requests for reprints should be addressed to Seymour Perry, M.D., Associate Scientific Director for Clinical Trials, National Cancer Institute, Bldg. 10, Room 6-B-15, National Institutes of Health, Bethesda, Md. 20014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCyclophosphamideFrom wild fowl to stalking horses: Alchemy in chemotherapy.Fifth annual David A. Karnofsky memorial lectureCyclophosphamide: Use in PracticeM. ERIC GERSHWIN, M.D., EDWARD J. GOETZL, M.D., ALFRED D. STEINBERG, M.D.Die LymphogranulomatoseHodgkin's disease: a review of changes over 40 yearsAdult Hodgkin's disease in UgandaPresent Position of Radical and Palliative Treatment of Malignant LymphomasCorrelation between clinicohistologic staging and extranodal relapse in Hodgkin's diseaseTolerance to Chemotherapy After Prior Irradiation for Hodgkin's DiseaseROBERT E. CURRAN, M.D., RALPH E. JOHNSON, M.D.Chemotherapy of Malignant DiseasePrognosis in Hodgktn's Disease with Special Reference to Histologic Type: Results of Treatment Predominantly by CytostaticsCorticosteroid therapy for lymphomas and chronic lymphocytic leukemiaCancer chemotherapyHodgkin's disease of the mandibleVinblastine VS. nitrogen mustard therapy of Hodgkin's diseaseCHEMOTHERAPY OF HODGKIN'S DISEASE, LYMPHOMA, AND LEUKEMIA 1 August 1967Volume 67, Issue 2Page: 424-442KeywordsHodgkin lymphomaMedical servicesPrevention, policy, and public health ePublished: 1 December 2008 Issue Published: 1 August 1967 PDF downloadLoading ...