Carbohydrate Metabolism in Cardiovascular Disease
Authors: MARGARET J. ALBRINK
Journal: Annals of Internal Medicine (1965)

Editorials1 June 1965Carbohydrate Metabolism in Cardiovascular DiseaseMARGARET J. ALBRINK, M.D.MARGARET J. ALBRINK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-6-1330 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years the pendulum of opinion regarding the etiology of atherosclerosis has swung away from the mechanistic view that ingested fat and cholesterol merely find their way through the blood stream to the arterial wall, toward the concept of an underlying metabolic abnormality. Growing evidence suggests than an important and perhaps basic defect is in the area of carbohydrate metabolism. Two papers in the current issue of the ANNALS shed light on different aspects of the problem. The paper by Ostrander, Francis, Hayner, Kjelsberg, and Epstein (1), as part of a population study of the town of Tecumseh, Mich.,...References1. OSTRANDERFRANCISHAYNERKJELSBERGEPSTEIN LDTNSMOFH: The relationship of cardiovascular disease to hyperglycemia. Ann. Intern. Med. 62: 1138, 1965. LinkGoogle Scholar2. KUOBASSETT PTDR: Dietary sugar for the production of hyperglyceridemia. Ibid., p. 1199. Google Scholar3. YUDKIN J: Dietary fat and dietary sugar in relation to ischemic heart disease and diabetes. Lancet 2: 4, 1964. CrossrefMedlineGoogle Scholar4. YUDKINRODDY JJ: Levels of dietary sucrose in patients with occlusive atherosclerotic disease. Ibid., p. 6. Google Scholar5. COON CS: The Origin of Races. Alfred A. Knopf, New York, 1963, p. 307. Google Scholar6. SCHEINBERG P: Observations on cerebral carbohydrate metabolism in man. Ann. Intern. Med. 62: 367, 1965. LinkGoogle Scholar7. CARLSONEKELUNDORO LALL: Studies on blood lipids during exercise. J. Lab. Clin. Med. 61: 724, 1963. MedlineGoogle Scholar8. RABINOWITZKLASSENZIERLER DGAKL: Effects of human growth hormone on muscle and adipose tissue metabolism in the forearm of man. J. Clin. Invest. 44: 51, 1965. CrossrefMedlineGoogle Scholar9. RANDLEGARLANDHALESNEWSHOLME PJPBCNEA: The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1: 785, 1963. CrossrefMedlineGoogle Scholar10. WHITNEYROBERTS JES: Influence of previous diet on hepatic glycogenesis and lipogenesis. Amer. J. Physiol. 181: 446, 1955. CrossrefMedlineGoogle Scholar11. SWEENEY JS: Dietary factors that influence the dextrose tolerance test: a preliminary study. Arch. Intern. Med. (Chicago) 40: 818, 1929. CrossrefGoogle Scholar12. TEPPERMANTEPPERMAN HMJ: Adaptive hyperlipogenesis. Fed. Proc. 23: 73, 1964. MedlineGoogle Scholar13. COHN C: Feeding patterns and some aspects of cholesterol metabolism. Ibid., p. 76. Google Scholar14. NEEL JV: Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Amer. J. Hum. Genet. 14: 353, 1962. MedlineGoogle Scholar15. ALBRINKMEIGS MJJW: Interrelationship between skinfold thickness, serum lipids and blood sugar in normal men. Amer. J. Clin. Nutr. 15: 255, 1964. CrossrefMedlineGoogle Scholar16. MEIGSCALDWELLALBRINK JWTBMJ: Some relationships between parental histories of coronary disease, longevity of parents and serum triglycerides. Arch. Environ. Health (Chicago). In press. Google Scholar17. WALKER JB: Diabetes in a village community, in Aetiology of Diabetes Mellitus and its Complications, edited by CAMERON, M. P., O'CONNER, N., Little, Brown and Co., Boston, 1964, p. 5. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine West Virginia University School of Medicine Morgantown, W. Va. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySerum and liver lipid responses to 3-hydroxy-3-methylglutaric acid in rats on different carbohydrate dietsReferencesElectrocardiography and Carbohydrate MetabolismAre the Massive Diet Fat-Heart and Coronary Drug Studies Justified?Diets, Drugs, and Their Interrelationships . A Brief AppraisalSPECIAL ARTICLETHE ROLE OF DIABETOGENIC HYPERINSULINISM IN NOCTURNAL ANGINA PECTORIS, WITH SPECIAL REFERENCE TO THE ETIOLOGY OF ISCHEMIC HEART DISEASE*The effect of phenformin hydrochloride on serum cholesterol and triglyceride levels of the stable adult diabeticTHE ROLE OF DIABETOGENIC HYPERINSULINISM IN THE PATHOGENESIS OF PROSTATIC HYPERPLASIA AND MALIGNANCY* 1 June 1965Volume 62, Issue 6Page: 1330-1333KeywordsAtherosclerosisBloodCarbohydrate metabolismCardiovascular diseasesCholesterolEtiologyFatsRivers Issue Published: 1 June 1965 PDF DownloadLoading ...