tbuckley/cabot-search huggingface dataset:
Prior aspirin use potentiates the effect of GP IIb/IIIa inhibition in patients with non-ST elevation acute coronary syndromes
Authors: J.H. Alexander, R.A. Harrington, A. Guerci, B.D. Weatherley, K.R. Karsch, R.M. Califf, E.J. Topol, A.M. Lincoff, P.W. Armstrong
Journal: Journal of the American College of Cardiology (1998)
Online Programs Help With Weight Loss
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
121 Analysis of IgE antibody responses to D. pteronyssinus and Blomia tropicalis using recombinant Group 5 allergens
Authors: L VAILES, M RIZZO, C NASPITZ, F MONTEALEGRE, E FERNANDEZCALDAS, T PLATTSMILLS, M CHAPMAN, L ARRUDA
Journal: Journal of Allergy and Clinical Immunology (1996)
Health inequalities in Australia.
Authors: P C Arnold
Journal: BMJ (1993)

policy that aims to deliver infants weighing less than 1000 g in a larger unit.We accept that in utero transfer is vastly superior to postnatal transfer and aim to transfer infants of 27 weeks or less if possible.This policy enables us to maintain the skills necessary to deal with such infants in the short term if they are born locally or if the regional unit is full.The Audit Commission's statements on neonatal care are far too influenced by the vested interests of the larger units, to the detriment of neonates.
Recombinant tissue-type plasminogen activator versus a novel dosing regimen of urokinase in acute pulmonary embolism: a randomized controlled multicenter trial
Authors: Samuel Z. Goldhaber, Craig M. Kessler, John A. Heit, C.Gregory Elliott, William R. Friedenberg, Darell E. Heiselman, David B. Wilson, John Anthony Parker, Don Bennett, Michael L. Feldstein, Andrew P. Selwyn, Ducksoo Kim, G.V.R.K. Sharma, James S. Nagel, Michael F. Meyerovitz
Journal: Journal of the American College of Cardiology (1992)
Successful Management of Postoperative Pancreatic Fistula by Application of Constructed S-Type Pancreatic Stent After Operation for Abnormal Biliary-Pancreatic Junction
Authors: T. Ukita, A. Moriyama, A. Tada, J. Shimura, H. Inoue, T. Kakemura, I. Maetani, Y. Igarashi, Y. Sakai, M. Nakamura
Journal: Endoscopy (2003)

We describe here our experience of successful closure of a lesion of the main pancreatic duct by means of a constructed S-type pancreatic stent.
Abstract 3800: Osteonectin suppresses proliferation and migration of human prostate cancer cells.
Authors: Minkyoung Shin
Journal: Cancer Research (2013)

Abstract Osteonectin/SPARC(Secreted Protein Acidic and Rich in Cysteine)/BM-40 is an extracellular protein that has been studied in ECM(Extra Cellular Matrix) organization, immune modulation, proliferation, adhesion, invasion and migration in various cancers. Advanced prostate cancer (PCa) is significantly affected by cross-talk among cancer cells, stromal cells and ECM. Such communication is particularly could contribute to migration and invasion of prostate cancer cells. However, the precise mechanism in migration and invasion of PCa cells are poorly understood. In this report, we investigated the effect of osteonectin on proliferation, migration and invasion of PCa cells. Indeed, Prostate-derived stromal cells (PrSC) has been shown to express high mRNA levels of osteonectin and secret relatively high levels of osteonectin. We revealed that osteonectin from PrSC and refined osteonectin protein also inhibited activation of AKT-p21 signaling, which plays an important role in prostate cancer cell growth, and affected down-regulation of migration and invasion of LNCaP cells. Together, these studies support a conclusion that interaction of stromal cells and PCa cells as osteonectin play an important role in progression of prostate cancer. Citation Format: Minkyoung Shin. Osteonectin suppresses proliferation and migration of human prostate cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3800. doi:10.1158/1538-7445.AM2013-3800
Regulation of sodium-hydrogen exchange in vascular smooth muscle
Authors: P. A Lucchesi, B. C Berk
Journal: Cardiovascular Research (1995)

The Na+/H+ exchanger in vascular smooth muscle cells represents a major mechanism for sodium influx and is also one of the principal mechanisms responsible for the regulation of intracellular pH (pHi). In this review, the relationship between pHi and vascular smooth muscle cell growth, the regulation of Na+/H+ exchange by vasoactive agents and growth factors, and the second messenger pathways that may be involved in activation of Na+/H+ exchange have been discussed. The exchanger appears to be important in vascular smooth muscle cell growth, based on results that (1) Na+/H+ exchange is stimulated by hypertrophic and hyperplastic agonists, (2) vascular smooth muscle cell proliferation is induced by cytoplasmic alkalinisation in the absence of mitogens, (3) vascular smooth muscle cell proliferation is dependent on extracellular sodium, and (4) inhibitors of Na+/H+ exchange block cell growth. Several pathways appear capable of activating the exchanger in vascular smooth muscle cells as there is evidence for both calcium and protein kinase C dependent and independent pathways. We speculate that the calcium and protein kinase C dependent pathways may play a role in the contractile response of differentiated vascular smooth muscle cells in the vessel wall, while the calcium and protein kinase C independent pathways may be involved in the proliferative response observed after arterial injury and in tissue culture.
Incest: Understanding and Treatment
Authors: Leon Tec
Journal: JAMA (1983)

Incest is a forbidden sexualized relationship between family members. Incest prohibitions exist in every society and, as such, are surrounded by strong feelings of aversion, shame, and guilt. According to the author, no instinctive aversion to incest exists, nor is there a catastrophic outcome to inbreeding. Instead, Dr Renshaw assumes that sexual feelings and fantasies are a normal part of everyday life, and sexual attraction may naturally arise between family members. Dr Renshaw defines incest as a sexual learning disorder. Thus, some family members have not learned to desexualize affectionate touch or have not learned or accepted that incest is socially inappropriate or morally wrong. Among professionals working with incest, emotional reactions may unexpectedly arise, and when they do, they interfere with therapy. In western cultures, criminalization of incest conflicts with the formation of therapeutic alliances between therapists and patients. Some court experts believe that emotional burdens on the members
Myoglobinuria and Renal Failure Associated with Influenza
Authors: J. L. MORGENSEN
Journal: Annals of Internal Medicine (1974)

Myoglobinuric renal failure occurred in association with influenza A2 (London) upper respiratory infection in a previously healthy 21-year-old man. The usual influenza symptoms of nonproductive cough, sore throat, nausea, mild diarrhea, and myalgia progressed to dehydration and concomitant tender muscles and myoglobinuria. Thrombocytopenia was also noted. The influenza symptoms, thrombocytopenia, and myoglobinuric renal failure resolved spontaneously; however, the patient required brief supportive peritoneal dialysis before recovery was complete. Tender muscles in patients with upper respiratory-tract illness should alert physicians to this syndrome.
Single‐nucleotide polymorphisms in pigment genes and nonmelanoma skin cancer predisposition: a systematic review
Authors: M. Binstock, F. Hafeez, C. Metchnikoff, S.T. Arron
Journal: British Journal of Dermatology (2014)

Nonmelanoma skin cancer (NMSC) is the most common cancer in the U.S.A. The two most common NMSCs are basal cell carcinoma and squamous cell carcinoma. The associations of single-nucleotide polymorphisms (SNPs) in pigmentation pathway genes with NMSC are not well characterized. There is a series of epidemiological studies that have tested these relationships, but there is no recent summary of these findings. To explain overarching trends, we undertook a systematic review of published studies. The summarized data support the concept that specific SNPs in the pigmentation pathway are of importance for the pathogenesis of NMSC. The SNPs with the most promising evidence include MC1R rs1805007(T) (Arg151Cys) and rs1805008(T) (Arg160Trp), and ASIP AH haplotype [rs4911414(T) and rs1015362(G)]. There are a few other SNPs found in TYR, OCA2 and SLC45A2 that may show additional correlation after future research. With additional research there is potential for the translation of future findings to the clinic in the form of SNP screenings, where patients at high risk for NMSC can be identified beyond their phenotype by genotypically screening for predisposing SNPs.
Evidence that rifampicin can be used safely for non-tuberculous diseases.
Authors: G Acocella, W Brumfitt, J M Hamilton-Miller
Journal: Thorax (1980)

The incidence of primary resistance to rifampicin in Mycobacterium tuberculosis has been analysed in countries where rifampicin is restricted to use for treating tuberculosis and in countries where its use is not restricted. There is no evidence that rifampicin-resistant M tuberculosis strains are more common where the use of the drug is unrestricted. Resistance to rifampicin is less common than is resistance to streptomycin or to isoniazid. We can thus see no danger of producing resistant strains of M tuberculosis if rifampicin therapy is used for short periods for non-tuberculosis infections. The problem of resistance mutants arising in the non-tuberculous species being treated is overcome by combining rifampicin with trimethoprim.
Pathogenesis and Physiopathology of Cystic Fibrosis of the Pancreas
Authors: Paul A. di Sant'Agnese, Richard C. Talamo
Journal: New England Journal of Medicine (1967)

CYSTIC fibrosis of the pancreas is the most recently recognized of the major chronic diseases of man. Reported for the first time by Fanconi1 in Switzerland in 1936, fibrocystic disease of the pancreas was not recognized as a separate and distinct disorder until the extensive work of Dorothy Andersen in New York2 in 1938 and the simultaneous reports of Blackfan and May3 in Boston and Harper in Australia.4 Previously, patients with this disease had succumbed either to bronchopneumonia in infancy, so common in the preantibiotic era, or to malnutrition, but the underlying basic condition had not been recognized.On the . . .
Handwashing and Semmelweiss
Authors: CARL W. WALTER
Journal: Annals of Internal Medicine (1976)

Comments1 September 1976Handwashing and SemmelweissCARL W. WALTER, M.D.CARL W. WALTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-398_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Steere and Mallison (Ann Intern Med 83:683-690, 1975) wrongly emphasize "the great importance of handwashing by surgical and obstetric personnel in the prevention of nosocomial wound infection" as a contribution by Semmelweiss. Their reference is Slaughter's novel Immortal Magyar, Semmelweiss, Conqueror of Childbed Fever.Actually, Ignaz Semmelweiss described death from puerperal sepsis in 11 of 12 parturient women who were examined in sequence. The physician's fingers had merely been washed with soap and water after each patient. Goaded by this horror, he gained lasting fame by proving with startling clarity that the washed examining finger must be...References1. LOWBURYLILLYBULL EHJ: Disinfection of hands: removal of resident bacteria. Br Med J 1:1251-1256, 1963 CrossrefMedlineGoogle Scholar2. LOWBURYLILLYBULL EHJ: Disinfection of hands: removal of transient organisms. Br Med J 2:230-233, 1964 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Harvard Medical School Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMicrobial flora of hands of homemakersEpidemiologic methods for the prevention of nosocomial infectionsBland Soap Handwash or Hand Antisepsis? The Pressing Need for ClarityBland Soap Handwash or Hand Antisepsis? The Pressing Need for ClarityFailure of Bland Soap Handwash to Prevent Hand Transfer of Patient Bacteria to Urethral CathetersA Causal Link Between Handwashing and Risk of Infection? Examination of the EvidenceA Causal Link between Handwashing and Risk of Infection? Examination of the Evidence 1 September 1976Volume 85, Issue 3Page: 398-398KeywordsFeversNosocomial infectionsSepsisSoaps Issue Published: 1 September 1976 PDF DownloadLoading ...
BMA guidelines on advertising.
Authors: R S Bhopal
Journal: BMJ (1991)

with her strong need to express love-two very different things.Among all deaths the sudden traumatic death of a young person tends to have the greatest impact on the bereaved, who therefore need particularly careful handling.Bereaved people should always be offered the chance to see the body, and generally this should be encouraged.It is an important part of accepting the reality and often helps to dispel the imagined disfigurement.Fact is generally preferable to fantasy, and what right have we to protect bereaved people?The deceased is their relative, and their feelings will tell them what they need to do.We are perhaps just protecting ourselves and hindering them in the process.Seeing the body is also a chance for the people to inspect, touch, hold, kiss, or say goodbye to their loved one.Staff should give permission for these free expressions, as well as allow the chance for bereaved people to be left alone with the body.2Some may need several visits.Sheila Awooner-Renner was unnecessarily (and cruelly) kept waiting, and when she eventually got to her son she felt inhibited and was watched.There was no need to wait for the coroner's officer.How are we to avoid this well meaning but inappropriate handling of distressed relatives?The hospice movement has led the way, but the acute sector needs a system for coping 24 hours a day.Accident and emergency departments are increasingly recognising the needs of bereaved people, regarding them as unofficial patients (often led by nurses).As well as the senior accident and emergency staff hospital chaplains, social workers,
Cause-Specific Excess Deaths Associated With Underweight, Overweight, and Obesity
Authors: Katherine M. Flegal, Barry I. Graubard, David F. Williamson, Mitchell H. Gail
Journal: JAMA (2007)

The association of body mass index (BMI) with cause-specific mortality has not been reported for the US population.To estimate cause-specific excess deaths associated with underweight (BMI <18.5), overweight (BMI 25-<30), and obesity (BMI > or =30).Cause-specific relative risks of mortality from the National Health and Nutrition Examination Survey (NHANES) I, 1971-1975; II, 1976-1980; and III, 1988-1994, with mortality follow-up through 2000 (571,042 person-years of follow-up) were combined with data on BMI and other covariates from NHANES 1999-2002 with underlying cause of death information for 2.3 million adults 25 years and older from 2004 vital statistics data for the United States.Cause-specific excess deaths in 2004 by BMI levels for categories of cardiovascular disease (CVD), cancer, and all other causes (noncancer, non-CVD causes).Based on total follow-up, underweight was associated with significantly increased mortality from noncancer, non-CVD causes (23,455 excess deaths; 95% confidence interval [CI], 11,848 to 35,061) but not associated with cancer or CVD mortality. Overweight was associated with significantly decreased mortality from noncancer, non-CVD causes (-69 299 excess deaths; 95% CI, -100 702 to -37 897) but not associated with cancer or CVD mortality. Obesity was associated with significantly increased CVD mortality (112,159 excess deaths; 95% CI, 87,842 to 136,476) but not associated with cancer mortality or with noncancer, non-CVD mortality. In further analyses, overweight and obesity combined were associated with increased mortality from diabetes and kidney disease (61 248 excess deaths; 95% CI, 49 685 to 72,811) and decreased mortality from other noncancer, non-CVD causes (-105,572 excess deaths; 95% CI, -161 816 to -49,328). Obesity was associated with increased mortality from cancers considered obesity-related (13,839 excess deaths; 95% CI, 1920 to 25,758) but not associated with mortality from other cancers. Comparisons across surveys suggested a decrease in the association of obesity with CVD mortality over time.The BMI-mortality association varies by cause of death. These results help to clarify the associations of BMI with all-cause mortality.
Combination Antibiotic Therapy of Bacterial Endocarditis
Authors: MERLE A. SANDE
Journal: Annals of Internal Medicine (1980)

A penicillin-aminoglycoside regimen is accepted therapy for enterococcal endocarditis, but use of combinations of antibiotics in other forms of bacterial endocarditis is controversial. This review analyzes in-vitro, experimental animal model, and clinical studies of combination "synergistic" antibiotic treatment for enterococcal, viridans streptococcal, staphylococcal, and gram-negative aerobic bacillary endocarditis. Current recommendations for treatment of these entities are discussed.
Abstract 4235: Antiproliferative effects of cucurbitacin B in breast cancer cells: Down-regulate c-Myc/hTERT/telomerase pathway and obstruct the cell cycle
Authors: Suwit Duangmano, Sumana Dakeng, Weena Jiratchariyakul, Apichart Suksamrarn, Duncan R. Smith, Pimpicha Patmasiriwat
Journal: Cancer Research (2011)

Abstract Abstract: Naturally occurring cucurbitacins have been shown to have anticancer, antimicrobial and anti-inflammatory activities. In this study, we determined the effects of cucurbitacin B extracted from Thai herb Trichosanthes cucumerina L. on the regulation of telomerase in three human breast cancer cell lines (T47D, SKBR-3, and MCF-7) and a mammary epithelium cell line (HBL-100). Cell viability after treatment with cucurbitacin B which is an active ingredient of this herb, was assessed by MTT assay and cell cycle analysis by flow cytometry. Telomeric Repeat Amplification Protocol (TRAP) assays and RT-PCR (qualitative and realtime) were performed to investigate activity of telomerase as well as expression of human telomerase reverse transcriptase (hTERT) and c-Myc. The c-Myc protein level was also determined in SKBR-3 and HBL-100. Our results show that the cucurbitacin B inhibits growth and telomerase activity in the three breast cancer cell lines and an obvious inhibitory effect was seen in the estrogen receptor (ER)-negative breast cancer cell SKBR-3 rather than ER-positive MCF-7 and T47D cells. The expressions of hTERT and c-Myc were also inhibited by cucurbitacin B, In addition, the reduction of c-Myc protein after the treatment was clearly observed in SKBR-3 cells even at the ten times lower concentration of cucurbitacin B compared to the concentration used for the HBL-100. DNA flow cytometric analysis indicated that treatment with cucurbitacin B resulted in G2/M arrest. These results imply that cucurbitacin B exerts anticancer effect by inhibiting telomerase via down regulating both the hTERT and c-Myc expression and arrest of the cell cycle at G2/M phase in breast cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4235. doi:10.1158/1538-7445.AM2011-4235
Nanostructural Systems Developed with Positive Charge Generation to Drug Delivery
Authors: Fei‐Fei An, Weipeng Cao, Xing‐Jie Liang
Journal: Advanced Healthcare Materials (2014)

The surface charge of a nanostructure plays a critical role in modulating blood circulation time, nanostructure–cell interaction, and intracellular events. It is unfavorable to have positive charges on the nanostructure surface before arriving at the disease site because positively charged nanostructures interact strongly with blood components, resulting in rapid clearance from the blood, and suboptimal targeted accumulation at the tumor site. Once at the tumor site, however, the positive charge on the nanostructure surface accelerates uptake by tumor cells and promotes the release of payloads from the lysosomes to the cytosol or nucleus inside cells. Thus, the ideal nanocarrier systems for drug delivery would maintain a neutral or negatively charged surface during blood circulation but would then generate a positive surface charge after accumulation at the tumor site or inside the cancer cells. This Progress Report focuses on the design and application of various neutral or negatively charged nanostructures that can generate a positive charge in response to the tumor microenvironment or an external stimulus.
Protease Inhibitors — A Precarious Balance
Authors: Peter C. Harpel
Journal: New England Journal of Medicine (1983)

Hemorrhage resulting from genetic defects in the blood coagulation system represents one of the most dramatic clinical emergencies. Study of these disorders has led to effective approaches for both the control and prevention of bleeding episodes and to remarkable advances in the understanding of the molecular biology of the hemostatic mechanism. An extraordinarily interesting report in this issue of the Journal 1 details an entirely new mechanism to explain a lifelong and ultimately fatal bleeding disorder in a young boy. Owen and colleagues identified a single amino acid substitution in an abnormal α1-antitrypsin in the blood of this patient. This mutation . . .
HEMOPERITONEUM FROM RUPTURED CORPUS LUTEUM
Authors: ABRAHAM STRAUSS
Journal: JAMA (1923)

It is now a well established fact that hemorrhage occurs more frequently from the ovary than from any other abdominal organ. In 1845, Scanzoni reported a case of fatal hemorrhage from the ovary at menstruation in a girl of 18, and the condition was referred to by earlier writers as apoplexy of the ovary. Novak<sup>1</sup>has described fully the types of ovarian hematomas, and has shown their relation to the graafian follicle. The forms of ovarian hematoma he divided into (1) follicular (graafian follicle and atretic follicle); (2) corpus luteum, and (3) stromal hematomas. Authors in the past have not seen fit to distinguish carefully between follicular and corpus luteum hemorrhages. Thus Moore, the most recent, has included both kinds in his table, compiling the cases reported in the literature, while he reported a case belonging to Class 2. Those seen at operation generally belong to Group 1, and