tbuckley/cabot-search huggingface dataset:
Desmopressin and Hypotension
Authors: E. J. P. Brommer, P. Van Brummelen, F. H. M. Derkx
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 December 1985Desmopressin and HypotensionE. J. P. BROMMER, P. VAN BRUMMELEN, F. H. M. DERKXE. J. P. BROMMERSearch for more papers by this author, P. VAN BRUMMELENSearch for more papers by this author, F. H. M. DERKXSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-962_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the review on desmopressin in the August issue (1), the scarcity of side effects is justly emphasized. Presumably because of the low dose administered, few investigators seem to have noticed the potent hypotensive capacity of the drug, which reveals itself only when desmopressin is infused intravenously. Facial flushing and a feeling of warmth reflect the vasodilatory action. A drop in diastolic blood pressure of about 14 mm Hg and an increase in heart rate of 20 beats/min are the rule during intravenous infusion of desmopressin in a dosage of 0.4 µg/kg body weight or more (2-4)....References1. RICHARDSONROBINSON DA. Desmopressin. Ann Intern Med. 1985;103:228-39. LinkGoogle Scholar2. BROMMERBARRETT-BERGSHOEFFALLENSCHICHTBERTINASCHALEKAMP EMRIRM. The use of desmopressin acetate (DDAVP) in testing of the fibrinolytic capacity of patients; analysis of responders and non-responders. Thromb Haemostas. 1982;48:156-61. CrossrefMedlineGoogle Scholar3. DERKXMAN'T VELDJONESREIDSCHALEKAMP FIARJM. DDAVP (1-desamino-8-D-arginine vasopressin): an antagonist of the pressor action of endogenous vasopressin? J Hypertension. 1983;1:58-61. Google Scholar4. BROMMERDERKXBARRETT-BERGSHOEFFSCHALEKAMP EFMM. The inability of propranolol and aspirin to inhibit the response of fibrinolytic activity and factor VIII-antigen to infusion of DDAVP. Thromb Haemostas. 1984;51:42-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCurrent Challenges in the Peripartum Management of Women with von Willebrand DiseaseHow I manage pregnancy in carriers of hemophilia and patients with von Willebrand diseaseVasodilation induced by vasopressin V2 receptor stimulation in afferent arteriolesNon-Responsiveness of T-Pa, U-Pa and VWF to DDAVPNephrogenic diabetes insipidus: clinical symptoms, pathogenesis, genetics and treatmentEvidence for intact V1-vasopressin receptors in congenital nephrogenic diabetes insipidusA variant of nephrogenic diabetes insipidus: V2 receptor abnormality restricted to the kidneyComment: Desmopressin in Postoperative BleedingDrug Information Analysis Service 1 December 1985Volume 103, Issue 6_Part_1Page: 962-962KeywordsBlood pressureBody weightDrugsEmotionsHeart rateHypotension Issue Published: 1 December 1985 PDF downloadLoading ...
Abstract 4503: Targeting sphingosine kinase 1 is promising novel strategy against breast cancer
Authors: Masayuki Nagahashi, Subramaniam Ramachandran, Omar Rashid, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe
Journal: Cancer Research (2010)

Abstract INTRODUCTION: Sphingosine kinase 1 (SphK1) is one of the key enzymes that regulates levels of the potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P). S1P promotes cancer cell survival, proliferation and angiogenesis. Expression of SphK1 is up-regulated in breast cancer and is associated with cancer progression. The aim of this study is to explore the therapeutic implications of targeting SphK1 for breast cancer treatment. We have examined the role of SphK1 in breast cancer proliferation with an isozyme-specific pharmacological inhibitor of SphK1, SK1-I, which does not inhibit other sphingosine kinases, or by gene silencing of SphK1. METHODS: 4T1-luc2 cells, murine ER negative breast cancer cells that overexpress luciferase were used. siRNA targeted to a specific sequence of mouse SphK1 mRNA (siSphK1) was used for down-regulation of the gene. Western blotting, qPCR, luciferase and colony formation assays were used to investigate SphK1 expression and responsiveness to SK1-I. RESULTS: qPCR demonstrated that 4T1-luc2 cells overexpress mRNA of SphK1, SphK2, S1P receptors 1, 2, and 4. Down-regulation of SphK1 mRNA using siSphK1 in these cells was confirmed both by qPCR and Western blotting. siSphK1 suppressed the growth of 4T1 cells determined by luciferase assays which also revealed that SK1-I inhibited 4T1 cell proliferation in a dose-dependent manner. Of note, SK1-I inhibited 4T1 cell growth synergistically with the chemotherapeutic drug doxorubicin. Moreover, siSphK1 or SK1-I also reduced colony formation of these cells. CONCLUSIONS: Our results support the notion that SphK1 is an important factor in breast cancer proliferation and suggest that SK1-I, an isozyme-specific inhibitor of SphK1, deserves consideration as a new therapeutic agent for this disease. SK1-I could be an important adjunct to anticancer therapy, allowing the use of reduced doses of a cytotoxic chemotherapeutic drug with the same antitumoral efficacy. This work was supported by NIH grant 5K12HD055881 and Susan G. Komen for the Cure Career Catalyst Research Grant KG090510 to KT, NCI grant R01CA61774 to SS, and Sumitomo Life Social Welfare Services Foundation to MN. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4503.
Angio-immunoblastic T cell lymphoma (AILD-TL) rich in large B cells and associated with Epstein–Barr virus infection. A different subtype of AILD-TL?
Authors: C Lome-Maldonado, D Canioni, O Hermine, E Delabesse, D Damotte, E Raffoux, P Gaulard, E Macintyre, N Brousse
Journal: Leukemia (2002)
Diabetes Is the Main Factor Accounting for the High Ferritin Levels Detected in Chronic Hepatitis C Virus Infection
Authors: Giada Sebastiani, Alessandro Vario, Alfredo Alberti
Journal: Diabetes Care (2005)

We read with interest the article by Lecube et al. (1) regarding the strong association they observed between diabetes and serum ferritin in chronic hepatitis C. We sought to analyze the contribution of biochemical, metabolic, and histological parameters to high ferritin levels detected in hepatitis C.

We investigated a large consecutive series of 177 patients with chronic hepatitis C who underwent a diagnostic liver biopsy. Serum ferritin was tested in a univariate analysis against demographics, biochemical parameters, and histological features. Patients with cirrhosis or with any alcohol intake were excluded. …
Another war ... and more lessons for medicine to ponder in aftermath
Authors: P. Gunby
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ileostomy or ileorectal anastomosis for ulcerative colitis?
Authors: P F Jones, P G Bevan, P R Hawley
Journal: BMJ (1978)

radiopharmaceuticals) was relatively small.The total costs of carrying out diagnostic tests are much higher than is often recognised by those who request them.The use of relatively expensive, commercially available assay kits saves time and gives good value for money.It may be worth taking this into account when planning hospital budgets.
Fundamentals of Gynecology
Authors: Irwin B. Kaiser
Journal: JAMA (1966)

Fundamentals of Gynecology, now after seven years in its second edition, is the product of two senior members of the Department of Obstetrics and Gynecology of the University of Michigan. The volume is a systematic basic review of the major concerns of gynecology, for the most part presented clearly and attractively. The illustrations are well done and illuminate the text. Particularly outstanding are the photomicrographs with diagrammatic abstractions of their significant features laid out, to scale, immediately adjacent. This is a splendid technique for the elucidation of microscopical pathology and it is very well used.  The authors do not make lengthy expositions of controversial matters but state the established practice of their own institution. This produces a good text for students and young house officers but not one which can be used as a work of reference by specialists or men in advanced training.  The publishers should be taken to
Annual mammography after breast cancer may improve survival, researchers say
Authors: J. Wise
Journal: BMJ (2011)

<h3>Introduction</h3> A cancer diagnose, for example, colorectal cancer, not only affects the cancer-person stricken, but also the surrounding family. Thus, this scoping review intends to identify appropriate models of support that will guide the development of a model of support to family members during the trajectory of colorectal cancer. <h3>Methods and analysis</h3> This scoping review will be guided by the methodological framework developed by Arksey and O9Malley, refined by Levac <i>et al</i> and Colquhoun <i>et al</i>, and described by the Joanna Briggs Institute. All the stages will be conducted iteratively and reflexively. First, a search strategy will be developed with a librarian and applied in the following peer-reviewed databases: PubMed, Cumulative Index to Nursing and Allied Health Literature and PsycINFO. Additional searches will be performed in Google Scholar and SwePub for identification of grey literature and hand searched in the reference lists. Searches will be conducted from December 2019 to February 2020. A draft of the preliminary search strategy was performed in PubMed in November 2019. Subsequently, three members of the research team will independently screen all abstracts for relevance, as well as the full-text articles. Studies meeting the inclusion criteria will be critically evaluated using the Joanna Brigg Institute Critical Appraisal Tools. A descriptive summary of study characteristics and of the scoping review process will be presented, including a visual flow diagram. Lastly, a thematic analysis as presented by Braun and Clarke will be conducted. To enhance validity, contact nurses of persons with colorectal cancer will be provided an overview of the preliminary results. <h3>Ethics and dissemination</h3> Being a secondary analysis, ethical approval is not needed for this study. The findings of the analysis will be used to inform the design of a future study aiming to develop a model of support and an upcoming scoping review, which will be published in a scientific journal and presented at relevant conferences.
Serum Amyloid A Regulates Granulomatous Inflammation in Sarcoidosis through Toll-like Receptor-2
Authors: Edward S. Chen, Zhimin Song, Matthew H. Willett, Shannon Heine, Rex C. Yung, Mark C. Liu, Steve D. Groshong, Ying Zhang, Rubin M. Tuder, David R. Moller
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

The critical innate immune mechanisms that regulate granulomatous inflammation in sarcoidosis are unknown. Because the granuloma-inducing component of sarcoidosis tissues has physicochemical properties similar to those of amyloid fibrils, we hypothesized that host proteins capable of forming poorly soluble aggregates or amyloid regulate inflammation in sarcoidosis.To determine the role of the amyloid precursor protein, serum amyloid A, as an innate regulator of granulomatous inflammation in sarcoidosis.Serum amyloid A expression was determined by immunohistochemistry in sarcoidosis and control tissues and by ELISA. The effect of serum amyloid A on nuclear factor (NF)-kappaB induction, cytokine expression, and Toll-like receptor-2 stimulation was determined with transformed human cell lines and bronchoalveolar lavage cells from patients with sarcoidosis. The effects of serum amyloid A on regulating helper T cell type 1 (Th1) granulomatous inflammation were determined in experimental models of sarcoidosis, using Mycobacterium tuberculosis catalase-peroxidase.We found that the intensity of expression and distribution of serum amyloid A within sarcoidosis granulomas was unlike that in many other granulomatous diseases. Serum amyloid A localized to macrophages and giant cells within sarcoidosis granulomas but correlated with CD3(+) lymphocytes, linking expression to local Th1 responses. Serum amyloid A activated NF-kappaB in Toll-like receptor-2-expressing human cell lines; regulated experimental Th1-mediated granulomatous inflammation through IFN-gamma, tumor necrosis factor, IL-10, and Toll-like receptor-2; and stimulated production of tumor necrosis factor, IL-10, and IL-18 in lung cells from patients with sarcoidosis, effects inhibited by blocking Toll-like receptor-2.Serum amyloid A is a constituent and innate regulator of granulomatous inflammation in sarcoidosis through Toll-like receptor-2, providing a mechanism for chronic disease and new therapeutic targets.
Scintigraphic and Sonographic Diagnosis of Neonatal Mesoblastic Nephroma
Authors: GLYNIS SACKS, MARK MITCHELL, ARTHUR C. FLEISCHER, MARTIN SANDLER
Journal: Clinical Nuclear Medicine (1983)

The morphologic characteristics of mesoblastic nephroma result in a scintigraphic appearance which distinguishes this benign neonatal tumor from Wilms' tumor. This case report describes a patient in whom the use of scintigraphy and real-time sonography permitted preoperative diagnosis of mesoblastic nephroma.
Association between early graft patency and late outcome for patients undergoing artery bypass graft surgery.
Authors: B L Gould, P D Clayton, R L Jensen, H V Liddle
Journal: Circulation (1984)

For a group of 658 patients who received coronary artery bypass graft surgery, we investigated the correlation between the degree of early (6 months) graft patency and recurrence of anginal symptoms, late myocardial infarction, and postoperative coronary-related death. The patients were grouped according to the number of surgically placed grafts, and each group was further subgrouped on the basis of the number of grafts functioning at the early postsurgical follow-up examination. The patients were observed over a period as long as 13 years. The frequency with which angina returned correlated significantly with the degree of patency within each of the groups (one, two, three, or four grafts); patients with a higher percentage of patent grafts experienced longer periods of freedom from angina. On the average, patients with all of their multiple grafts patent experienced at least 7 more years of symptomatic relief than their counterparts with all grafts occluded. Most surprisingly, the rate of the return of angina for those patients who had all grafts patent and were completely revascularized was independent of the number of diseased vessels or the number of grafts placed. The findings for coronary death and postoperative infarction showed similar trends.
LUXATION OF THE ENSIFORM PROCESS.
Authors: LUCIEN LOFTON
Journal: JAMA (1896)

Dislocation of the xyphoid appendix is a rare occurrence, and only a few instances have been recorded. Owing to the rarity of this accident, I deem it important to give it publicity. The patient, a German, aged 33 years, and of of a robust build, consulted me for what he termed "chronic indigestion" about one year ago. He gave the following history: About three years prior to coming to the city he was in Philadelphia on a visit. During his meanderings he inbibed too freely and mistaking a lamp post for the middle of the sidewalk ran against it with great force, receiving a terrific blow, as he explained, about the "pit" of the stomach. The blow felled him to the pavement where he lay unconscious for a few minutes. He was removed to his hotel where he rested fairly well the night of the accident. During the night he
P249 UBIQUITOUS TRANSGENIC OVEREXPRESSION OF C–C CHEMOKINE LIGAND 2: A MODEL TO ASSESS THE COMBINED EFFECT OF HIGH ENERGY INTAKE AND CONTINUOUS LOW-GRADE INFLAMMATION?
Authors: A. Hernández-Aguilera, M. Riera-Borrull, E. Rodríguez-Gallego, R. Mariné-Casadó, M. Guirro, S. Fernández-Arroyo, A. García-Heredia, F. Luciano-Mateo, A.A. Martí-Líndez, R. Beltrán-Debón, J. Joven
Journal: Journal of Hepatology (2014)
Why Danes are smug: comparative study of life satisfaction in the European Union
Authors: Kaare Christensen, Anne Maria Herskind, James W Vaupel
Journal: BMJ (2006)

Danes are unrivalled in satisfaction with life. The University of Leicester recently published the World Map of Happiness (http://news.bbc.co.uk/2/shared/bsp/hi/pdfs/28\_07\_06\_happiness\_map.pdf) with Denmark as number one. For more than 30 years this country with five million inhabitants has ranked first in Eurobarometer surveys (europa.eu.int/comm/public\_opinion/index\_en.htm). More than two thirds of Danes are “very satisfied” with their lives according to these surveys. In no other Eurobarometer country has this proportion exceeded a half, and for most of the countries the proportion is less than a third (figure)⇓. To explain Danish contentment we sifted through literature, statistics, and common knowledge. 



Proportion who report to be very satisfied in 15 EU countries according to Eurobarometers (europa.eu.int/comm/public\_opinion/index\_en.htm) 



We focused on accounting for why life satisfaction in Denmark substantially exceeds that in Sweden and Finland, the two Eurobarometer countries most similar to Denmark. We have ordered our hypotheses roughly from most to least implausible. 

Hair colour —It may indeed be the case that “blondes have more fun.” This hypothesis was launched in the 1950s by a commercial slogan for a hair dye and was cemented in popular culture in 1978 by rock musician Rod Stewart's album of the same title. Sweden, however, has a higher prevalence of blondes than Denmark.1 

Genes —Genetic factors might influence differences in life satisfaction within a country,2 and Danes might have a special genetic constitution. Genotypes in Sweden, however, are similar to those in Denmark because most Swedes were Danes until the 17th century. 

Food— Meals in Denmark can be politely described as unmemorable. “Danish cuisine” is an oxymoron, except perhaps the open faced “butter breads” that accompany the beer and aquavit Danes consume for lunch. Older Danes satisfy their hunger with potatoes, gravy, and a bit of pork, and younger ones devour hotdogs, hamburgers, and Baltic-style pizzas. Danish …
BMA annual representative meeting: Sperm donors should be guaranteed anonymity
Authors: Linda Beecham
Journal: BMJ (2004)

The BMA has reiterated its view that sperm donors should be guaranteed anonymity. Representatives defeated a motion saying that sperm donors should not be given anonymity in future, despite the fact that the government was moving towards that position. The government has proposed that anonymity should be removed from April 2005, though it has specified that the change …
Blue Macule on the Volar Surface of the Left Thumb—Quiz Case
Authors: Loren Zech, Norris Nolan, Scott A. Norton
Journal: JAMA Dermatology (2013)

A 34-year-old, right-handed man presented with a 3-year history of a blue macule on the volar surface of his left thumb. The lesion had progressively become more painful and was affecting his work as a professional painter. He reported that he cut his thumb 3 years earlier while using a high-pressure paint sprayer. Physical examination showed a nearly triangular bluish-gray macule about 1 cm long (Figure 1). A 2-mm punch biopsy specimen was obtained, and on gross examination, it showed a solid dark blue dermis with several 1to 1.8-mm white, glistening, rice-grain– shaped globules on the distal aspect of the tissue core (Figure 2). Hematoxylin-eosin–stained tissue specimens were also prepared (Figure 3). What is your diagnosis?
Progressive Myelopathy-Reply
Authors: Kedar Chintapalli
Journal: JAMA (1985)

<h3>In Reply.—</h3> I agree with the comments of Drs Sarwar and Naseem. Unfortunately, MRI is done in patients with no previous radiographic studies, such as CT. Magnetic resonance imaging has, in my opinion, limited use in the evaluation of calcifications as they appear as low-intensity signals. Plain roentgenograms may demonstrate the abnormality better than MRI studies. Computed tomography due to the axial display of the ligamentum flavum localizes the calcifications well. Dr Olson's comments are well taken. Ligamentous ossification involving the ligamentum flavum or posterior longitudinal ligament contributes to spinal stenosis. Trauma, vascular lesions, and a tendency to ossify ligaments, such as in diffuse idiopathic skeletal hyperostosis (Forestier's disease), are some of the causes of ossification. Ossification may be an associated radiological abnormality, as in patients with thoracic posterior longitudinal ligament ossification.<sup>1</sup>
Constitutively, pathologically, profoundly
Authors: Ushma S. Neill
Journal: Journal of Clinical Investigation (2012)

There are a hundred reasons to love the JCI and I have loved it truly, madly, and deeply for the last nine years. Alas, I’ll have to learn to love the Journal from afar, as tomorrow marks my last official day as Executive Editor. To quote Chaucer, “There is an end to everything, to good things as well.”
Relative palatability of liquid enteral feeds for general hospital patients: simple method of assessment.
Authors: P L Auty, M A Standing, C Humphrey
Journal: BMJ (1983)

previously he had felt generally unwell and had experienced rigors the day before admission.He had a history of asthma but was not taking regular medication and had never been given corticosteroids.He was feverish (38-6°C) and the radiograph showed a dense area of consolidation in the right upper lobe.Sputum and blood were obtained for culture and treatment begun with benzylpenicillin.The fever resolved within 24 hours of starting treatment and he recovered uneventfully.S pneumoniae capsular type 1 was isolated from the blood culture after overnight incubation.Sputum culture yielded mouth commensals only.