tbuckley/cabot-search huggingface dataset:
Publish and be damned?
Authors: H. Bower
Journal: BMJ (1997)

<h3>Abstract</h3> <h3>Background</h3> The ability to generate long sequencing reads and access long-range linkage information is revolutionizing the quality and completeness of genome assemblies. Here we use a hybrid approach that combines data from four genome sequencing and mapping technologies to generate a new genome assembly of the honeybee <i>Apis mellifera</i>. We first generated contigs based on PacBio sequencing libraries, which were then merged with linked-read 10x Chromium data followed by scaffolding using a BioNano optical genome map and a Hi-C chromatin interaction map, complemented by a genetic linkage map. <h3>Results</h3> Each of the assembly steps reduced the number of gaps and incorporated a substantial amount of additional sequence into scaffolds. The new assembly (Amel_HAv3) is significantly more contiguous and complete than the previous one (Amel_4.5), based on Sanger sequencing reads. N50 of contigs is 120-fold higher (5.381 Mbp compared to 0.053 Mbp) and we anchor &gt;98% of the sequence to chromosomes. All of the 16 chromosomes are represented as single scaffolds with an average of three sequence gaps per chromosome. The improvements are largely due to the inclusion of repetitive sequence that was unplaced in previous assemblies. In particular, our assembly is highly contiguous across centromeres and telomeres and includes hundreds of <i>AvaI</i> and <i>AluI</i> repeats associated with these features. <h3>Conclusions</h3> The improved assembly will be of utility for refining gene models, studying genome function, mapping functional genetic variation, identification of structural variants, and comparative genomics.
Vascular Outcome in Men with Asymptomatic Retinal Cholesterol Emboli: A Cohort Study
Authors: Askiel Bruno
Journal: Annals of Internal Medicine (1995)

Objective: To determine whether asymptomatic retinal cholesterol embolism is a risk factor for vascular events. Design: Cohort study with retrospectively selected controls. Setting: A Veterans Affairs medical center. Patients: 70 consecutive patients with asymptomatic retinal cholesterol emboli on dilated ocular examination in an eye clinic and 70 controls without retinal emboli. Controls were matched to patients for sex; age; prevalence of hypertension, diabetes mellitus, and ischemic heart disease; serum cholesterol level; and smoking history. Measurements: Stroke, myocardial infarction, and death. Results: During a mean follow-up of 3.4 years, stroke occurred at an annual rate of 8.5% among patients and 0.8% among controls (adjusted relative risk, 9.9; 95% CI, 2.3 to 43.1; P = 0.002). Nineteen strokes occurred, 17 in patients and 2 in controls; all were nonfatal cerebral infarctions. Twelve of the 17 that occurred in patients were in a carotid artery territory ipsilateral to the qualifying retinal cholesterol embolus and 5 were in another vascular territory. Ocular infarction or hemorrhagic stroke did not occur. Nonfatal myocardial infarction or vascular death occurred at an annual rate of 7.7% among patients and 4.9% among controls (adjusted relative risk, 1.4; 95% CI, 0.7 to 2.9; P = 0.39). Conclusion: Asymptomatic retinal cholesterol embolism is an important risk factor for cerebral infarction independent of commonly recognized vascular risk factors.
Medicine at the centre of the nation's affairs
Authors: M Shock
Journal: BMJ (1994)

The medical profession was shaped a century or so ago by the interaction of three forces. These were a class structure in which doctors were largely held to be gentlemen to whom deference was due, a society dominated by the activity of production (hence the label of the working class for the majority), and the doctrines of liberalism as the guiding star in politics. Prime Minister Gladstone defined his task as "opening doors and windows." The outcome was a minimum of government interference and control with the belief that professional self regulation was the way to ensure that practice matched principle. The state (the word was hardly ever used) was self effacing almost to the point of non-existence. These are ghosts of the past, but it is a comparatively recent past. Within memory, the major domestic preoccupation of politicians of all parties was how, and to what ends, the working class could be absorbed into the political system. Health had a crucial part to play in this task, as Lloyd George and others saw early on. The "panel" was very much a forerunner of the NHS. Indeed, Bevan based part of his case in 1946 on the claim that 21 million people were already on the "panel," clear evidence of the degree to which society was still dominated by production. While speaking of Nye Bevan, we might examine his claim that the NHS was "pure socialism." In fact, it was rather closer to being "impure liberalism" in the consideration with which general practitioners and consultants were treated, the considerable freedom enjoyed by local administrations, and the low profile of government itself. That is why many remember the period as something of a golden age. It suited almost everyone very well.
Dosage of Blennostasin.
Authors: None McKesson
Journal: JAMA (1900)

New York, Jan. 22, 1900. <h3>To the Editor:</h3> —Our attention has been called to a misprint in the third edition of "The Newer Remedies," by Prof. Virgil Coblentz, whereby the dose of blennostasin is given as from 1 to 4 grams (15 to 60 grains) instead of from 1 to 4 grains. Inasmuch as the work had been widely circulated prior to the correction, we would ask you to call the attention of the profession to the error, as the administration of so large a dose would, in all probability, cause serious complications. Very respectfully yours,
Schools and Doctrines of Hypnotism
Authors: E. Hart
Journal: BMJ (1891)

T'he T)o French Schools.--Jlraid an (l Charcot.-TheCataleptic State.-'he Lethafric State.-Induced Somnambulisi.-Le (Grand Ilqpnotitsin.-LeP)etit Hypnotismne.-TheDangers of Ilqpnr)tismn.-4ction at a Distance.-RevolvingMifirrors.-GeneralConclusions.AXTH.r is aetunall1y known of tlle question of lhypnotism was SUmnmfe(d UpJ roc(nltly ill th(e publislhed addresses and the dis- ('Ussions at the Inteirnational Congress of Hypnotism lheld in Paris.This suflice(l to slhow that all is not yet clear eveen as to the nature, not to say the grouping, of the plhenomena
Effect of Single-Drug Therapy on Reduction of Left Atrial Size in Mild to Moderate Hypertension
Authors: John S. Gottdiener, Domenic J. Reda, David W. Williams, Barry J. Materson, William Cushman, Robert J. Anderson
Journal: Circulation (1998)

Background —Cardiac effects of hypertension include increased left ventricular (LV) mass and LV hypertrophy, as well as increased left atrial size, a predictor of stroke and atrial fibrillation. Although literature on reduction of LV mass with antihypertensive therapy is extensive, little information is available on effects of treatment on left atrial size. Methods and Results —Patients with mild to moderate hypertension (diastolic blood pressure 95 to 109 mm Hg) were randomly allocated to treatment with atenolol, captopril, clonidine, diltiazem, hydrochlorothiazide, or prazosin in a double-masked trial. Two-dimensional targeted M-mode echocardiography was used to assess left atrial size and LV mass at baseline, 8 weeks, and 1 and 2 years. Longitudinal analysis examined changes in left atrial size from the baseline study, statistically adjusting for age, race, pretreatment left atrial size and LV mass, and serial measurements of systolic blood pressure, body weight, urinary sodium excretion, and physical activity score. Without adjustment for covariates, only hydrochlorothiazide was associated with decreases in left atrial size from baseline at 8 weeks (−1.0±5.2 mm; P =0.052), 1 year (−2.0±5.1 mm; P =0.02), and 2 years (4.6±7.2 mm; P =0.002). After adjustment for effects of covariates, patients with normal left atrial size had greater reduction (−3.3 mm) in left atrial size at 2 years with hydrochlorothiazide than with any other drug. For patients with left atrial enlargement, left atrial size decreased significantly with hydrochlorothiazide, atenolol, clonidine, and diltiazem at 1 year and with all treatments at 2 years. However, reduction at 2 years was greater with hydrochlorothiazide than with captopril or prazosin. Conclusions —Antihypertensive drugs differ in their effects on left atrial size. Hydrochlorothiazide was associated with greater overall reduction of left atrial size than other drugs effective for the treatment of hypertension. Reduction of left atrial size with therapy is in part independent of factors known to influence left atrial size, including LV mass and reduction of LV mass with treatment. The clinical benefit of reducing left atrial size with antihypertensive treatment remains to be determined.
223 ROLE OF THE HEPATIC CANCER STEM CELL IN THE RADIATIONINDUCED METASTASIS IN HEPATOCELLULAR CARCINOMA
Authors: S.W. Hong, C.-H. Park, M.J. Song, P.S. Sung, J.M. Yang, S.W. Choi, C.D. Lee, Y.S. Lee, S.K. Yoon
Journal: Journal of Hepatology (2011)
Abstract 560: Distinct protein expression patterns of solid pseudopapillary neoplasm of pancreas
Authors: Minhee Park, Minhee Cho, SeongJu Yoon, Hoguen Kim
Journal: Cancer Research (2014)

Abstract Solid pseudopapillary neoplasm (SPN), is an uncommon pancreatic tumor with distinct clinicopathologic features. SPNs are characterized by mutation in exon 3 of CTNNB1. However, little is known about SPN tumorigenesis but CTNNB1 mutation. In order to identify the characteristic gene expression patterns of SPN, we performed proteome analysis of SPN and compared to gene expression data. We analyzed pooled SPNs and pooled non-neoplastic pancreas tissues using LTQ-Orbitrap. In total, we identified 862 (444 up-regulated and 418 down-regulated) proteins showed differential expression in SPN compared to non-neoplastic pancreas. We compared proteome profiling compared to mRNA expression of SPNs, and then selected 544 significant proteins presented the same expressional tendency. Many of the overexpressed proteins are related to the activated signaling pathways of SPN consistently with our previous study. Specifically, DKK4 (6.1-fold), APC (1.5-fold), RUVBL1 (1.4-fold) and β-catenin (1.3-fold) involved in Wnt signaling were up-regulated in protein level of SPNs compared to non-neoplastic pancreas. Besides Wnt signaling, we detected several up-regulated proteins including FUS and NONO. The interaction of β-catenin with FUS was reported that involved in the regulation of pre-mRNA splicing. We identified that FUS and NONO interacted directly with β-catenin by immunoprecipitation in β -catenin active cell lines (SW480, HCT116). We found that molecules involved in glycolysis, metabolism and sumoylation were activated in SPNs; HK1 (3.2-fold), PKM2 (3.3-fold), ENO2 (2.1-fold), PDHA (1.5-fold) and SUMO2 (1.6-fold). We also detected that several proteins involved in epithelial-mesenchymal transition were up or down-regulated including CTSB (3.98-fold), VIM (1.98-fold) and JUP (-2.29-fold). Our proteomic profiling study of SPNs provides 1) SPN-specific molecular mechanism for solid-pseudopapillary neoplasm tumorigenesis similar with mRNA expression pattern including Wnt signaling, 2) SPN-specific epithelial-mesenchymal transition, and 3) a metabolism is activated in SPNs. These findings can be used for an early diagnosis biomarker development or molecular therapeutic target. Citation Format: Minhee Park, Minhee Cho, SeongJu Yoon, Hoguen Kim. Distinct protein expression patterns of solid pseudopapillary neoplasm of pancreas. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 560. doi:10.1158/1538-7445.AM2014-560
A CASE OF HYPERSENSITIVENESS TO CARBON TETRACHLORID
Authors: Harden F. Taylor
Journal: JAMA (1925)

As a result of pioneer work by Hall,<sup>1</sup>carbon tetrachlorid has recently come into extensive use for the destruction of the bookworm and other intestinal parasites, first in dogs, and then in man. While in the vast majority of cases no untoward effects seemed to result from the use of carbon tetrachlorid, in a few cases the animals died, even when the chemical was highly purified. The causes of these unfavorable results have been under investigation by Lamson and his collaborators,<sup>2</sup>who report that the presence of fats or alcohol in the subject's stomach, or the presence of certain other parasitic worms, may complicate the effects of carbon tetrachlorid, and be the cause of the casualties. A few exceedingly disagreeable experiences that I have had suggest that hypersensitiveness to carbon tetrachlorid may be another, and perhaps the chief, cause of the trouble in unfavorable cases. In 1917, I
Depression Following Myocardial Infarction
Authors: Nancy Frasure-Smith
Journal: JAMA (1993)

To determine if the diagnosis of major depression in patients hospitalized following myocardial infarction (MI) would have an independent impact on cardiac mortality over the first 6 months after discharge.Prospective evaluation of the impact of depression assessed using a modified version of the National Institute of Mental Health Diagnostic Interview Schedule for major depressive episode. Cox proportional hazards regression was used to evaluate the independent impact of depression after control for significant clinical predictors in the data set.A large, university-affiliated hospital specializing in cardiac care, located in Montreal, Quebec.All consenting patients (N = 222) who met established criteria for MI between August 1991 and July 1992 and who survived to be discharged from the hospital. Patients were interviewed between 5 and 15 days following the MI and were followed up for 6 months. There were no age limits (range, 24 to 88 years; mean, 60 years). The sample was 78% male.Survival status at 6 months.By 6 months, 12 patients had died. All deaths were due to cardiac causes. Depression was a significant predictor of mortality (hazard ratio, 5.74; 95% confidence interval, 4.61 to 6.87; P = .0006). The impact of depression remained after control for left ventricular dysfunction (Killip class) and previous MI, the multivariate significant predictors of mortality in the data set (adjusted hazard ratio, 4.29; 95% confidence interval, 3.14 to 5.44; P = .013).Major depression in patients hospitalized following an MI is an independent risk factor for mortality at 6 months. Its impact is at least equivalent to that of left ventricular dysfunction (Killip class) and history of previous MI. Additional study is needed to determine whether treatment of depression can influence post-MI survival and to assess possible underlying mechanisms.
Vitamin D Intoxication in an Anephric Child
Authors: SANDRA JO COUNTS
Journal: Annals of Internal Medicine (1975)

Although the biologically active metabolite of vitamin D, 1,25-dihydroxycholecalciferol, is synthesized exclusively by kidney tissue, severe hypercalcemia developed in an anephric child treated with large doses of vitamin D. Treatment by calcium-free peritoneal dialysis acutely reduced serum calcium from 17.2 to 14.2 mg/100 ml. This decrement was effected by removal of three times the total calcium in extracellular fluid, suggesting enhanced bone resorption. Oral prednisolone for 7 days reduced serum calcium to 13 mg/100 ml, but hypercalcemia recurred rapidly after prednisolone was stopped. Calcitonin, given for only 4½ days, produced normocalcemia. Maximum serum 25-hydroxyvitamin D (25-OHD), observed immediately after vitamin D was stopped, was 635 ng/ml (normal range 23-32 ng/ml) and subsequently decreased with an initial half-time of 10 days. Losses in peritoneal dialysate may have contributed to disappearance of serum 25-OHD. Because of the high serum levels of 25-OHD and absence of renal tissue, 25-OHD was the likely metabolite that caused hypercalcemia, probably by stimulation of bone resorption, though contribution to hypercalcemia by another vitamin D metabolite cannot be absolutely excluded.
Acute Barbiturate Intoxication.
Authors: John G. Setter
Journal: Annals of Internal Medicine (1964)

s1 October 1964Acute Barbiturate Intoxication.John G. Setter, M.D., John F. Maher, M.D., F.A.C.P., George E. Schreiner, M.D., F.A.C.P.John G. Setter, M.D., John F. Maher, M.D., F.A.C.P., George E. Schreiner, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-802_5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious studies of barbiturate intoxication have dealt predominantly with the "long" acting drugs. We have noted an increased incidence of intoxication due to short acting preparations. During a 14-year period, 140 intoxications occurred in 131 patients: 92 due to short acting barbiturates alone or in combination with other sedatives. The patients ranged from 1 (accidental) to 82 years of age. The youngest intentional overdose was 6 years old. The patients were predominantly female. There were 17 deaths: 12 after short acting, 3 after combinations, and 2 after undetermined types of barbiturate ingestions. Death was usually due to cardiopulmonary complications and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 802-802KeywordsDrugsIngestionIntoxicationSedatives Issue Published: 1 October 1964 PDF downloadLoading ...
Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay
Authors: Norbert H. Kleinsasser, Katharina Schmid, Andrea W. Sassen, Ulrich A. Harréus, Rainer Staudenmaier, Matthias Folwaczny, Jürgen Glas, Franz-Xaver Reichl
Journal: Biomaterials (2005)
Monoclonal B-cell lymphocytosis is characterized by mutations in CLL putative driver genes and clonal heterogeneity many years before disease progression
Authors: J Ojha, C Secreto, K Rabe, J Ayres-Silva, R Tschumper, D V Dyke, S Slager, R Fonseca, T Shanafelt, N Kay, E Braggio
Journal: Leukemia (2014)
976-15 Assessment of Pacing Maneuvers to Validate Anterograde Accessory Pathway Potentials
Authors: Mark J. Niebauer, Emile G. Daoud, Mark Harvey, S. Adam Strickberger, K. Ching Man, Rajiva Goyal, Mark Castellani, Frank Bogun, K.K. Chan, Fred Morady
Journal: Journal of the American College of Cardiology (1995)
Adult Open Heart Surgery in New York State
Authors: Edward L. Hannan
Journal: JAMA (1990)

This study analyzes data from New York State's new Cardiac Surgery Reporting System, which contains information about cardiac preoperative risk factors, postoperative complications, and hospital discharge. The purposes of the study were to determine the set of significant clinical risk factors and to identify cardiac surgical centers most likely to have serious quality-of-care problems. Significant risk factors for in-hospital death were age, gender, ejection fraction, previous myocardial infarction, number of open heart operations in previous admissions, diabetes requiring medication, dialysis dependence, disasters (acute structural defect, renal failure, cardiogenic shock, gunshot), unstable angina, intractable congestive heart failure, left main trunk narrowed more than 90%, and type of operation performed. Four of the 28 hospitals had significantly higher mortality rates than expected, given the risk factors of their patients. Subsequent site visits and medical record reviews confirmed that these facilities had high percentages of quality-of-care problems among cases resulting in mortality.
Munthe Axel M.D.
Authors: Norman J. Sissman
Journal: New England Journal of Medicine (1958)

ONE of the most popular best sellers of the present ^-^ time is The Story of San Michele, by the Swedish physician, Axel Munthe. Since its publication in 1929, it has been translated into at least twenty-three languages, has sold almost 1,000,000 copies and has appeared recently in a paperback edition. It won world renown for its author. What manner of man was this doctor afield, how did he practice medicine, and what did he write?Although he was born, in 1857, and died, in 1949, in Sweden, Munthe was a citizen of all Europe. At the age of . . .
Psychotherapy: experience as a medical student
Authors: H H Wolff, D A Sturgeon
Journal: BMJ (1981)

cationally important, learning difficulties in the very young; and it is therefore premature to conclude that 18 of the children with vaccine- associated illness were normal.At low levels of risk, estimates are of necessity imprecise, and this is asserted by the Epidemiological Panel as well as by the National Childhood Encephalopathy Study.An independent estimate of the risk of severe brain damage (80"' disability) is therefore relevant and is available in the awards made by medical panels advising the Government's vaccine damage payments scheme.2Last year there were 435 awards to children immunised with pertussis-containing vaccines, about three times the number for all other vaccines, indicating a risk over the period 1958-78 of the order of 1:30 000, with a number of cases yet to be settled.You seem satisfied in your leading article that pertussis vaccine is highly protective as well as safe.We would suggest that data on this point are far from being conclusive but our purpose in writing to you is more immedi- ate.You state categorically that, if 600 000 children born in Britain each year are given a course of pertussis vaccine, only two will have severe reactions with permanent disability.In our view, this is a serious understatement of the risk, not only because your estimate is based on error, but because lesser degrees of brain damage resulting from convulsions and other sequelae of immunisations should not be discounted.
Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: study of 27 cases in 500 patients.
Authors: H von der Maase, M Rorth, S Walbom-Jorgensen, B L Sorensen, I S Christophersen, T Hald, G K Jacobsen, J G Berthelsen, N E Skakkebaek
Journal: BMJ (1986)

Carcinoma in situ in the contralateral testis was diagnosed in 27 of 500 patients (5.4%) with unilateral testicular germ cell cancer. Eight of the 27 patients received intensive chemotherapy for spread of their initial testicular cancer. Follow up biopsy studies did not detect changes of carcinoma in situ in any of these patients, and none developed a contralateral testicular tumour (observation time 12-88 months). Of the remaining 19 patients with carcinoma in situ, seven developed contralateral testicular cancer. The estimated risk of developing invasive growth was 40% within three years and 50% within five years. None of the 473 patients without carcinoma in situ detected by screening biopsy developed contralateral testicular cancer (observation time 12-96 months). No serious complications arose from the biopsy procedures. All patients with unilateral testicular germ cell cancer should be offered biopsy of the contralateral testis.