Thyrotrophin in Albright's Syndrome with Hyperthyroidism
Authors: Brian S. Andrews, Solomon Posen, Stephen Podolsky
Journal: Annals of Internal Medicine (1974)

Letters1 October 1974Thyrotrophin in Albright's Syndrome with HyperthyroidismBRIAN S. ANDREWS, M.D., SOLOMON POSEN, M.D., STEPHEN PODOLSKY, M.D., F.A.C.P.BRIAN S. ANDREWS, M.D.Search for more papers by this author, SOLOMON POSEN, M.D.Search for more papers by this author, STEPHEN PODOLSKY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-4-561 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Various endocrinopathies have been described in association with polyostotic fibrous dysplasia (Albright's syndrome). These include precocious puberty in females, hyperthyroidism, acromegaly, Cushing's syndrome, and hyperparathyroidism (1-4). The nature of these associations is obscure. Suggested mechanisms include the abnormal secretion of pituitary trophic hormones or hypothalamic releasing factors because of the sclerotic lesions at the base of the skull or because of a congenital hypothalamic abnormality (5). We recently had the opportunity to study two patients with polyostotic fibrous dysplasia and hyperthyroidism. Neither showed elevation of immunoassayable thyrotrophin.PATIENT 1A 26-year-old man had 18 spontaneous fractures since...References1. ALBRIGHTBUTLERHAMPTON FAA: Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation and endocrine dysfunction, with precocious puberty in females. N Engl J Med 216:727-746, 1937 CrossrefGoogle Scholar2. SCURRYBICKNELLFAJANS MJS: Polyostotic fibrous dysplasia and acromegaly. Arch Intern Med 114:40-45, 1964 CrossrefMedlineGoogle Scholar3. AARSKOGTVETERAAS DE: McCune-Albright's syndrome following adrenalectomy for Cushing's syndrome in infancy. J Pediatr 73:89-96, 1968 CrossrefMedlineGoogle Scholar4. EHRIGWILSON UD: Fibrous dysplasia of bone and primary hyperparathyroidism. Ann Intern Med 77:234-238, 1972 LinkGoogle Scholar5. HALLWARRICK RC: Hypersecretion of hypothalamic releasing hormones: a possible explanation of the endocrine manifestations of polyostotic fibrous dysplasia (Albright's syndrome). Lancet 1:1313-1316, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHipertireoidismo relacionado à síndrome de McCune Albright: relato de dois casos e revisão da literaturaMcCune-Albright Syndrome and Disorders Due to Activating Mutations of GNAS1Hyperthyroidism in McCune-Albright Syndrome with a Review of Thyroid Abnormalities Sixty Years After the First ReportHyperthyroidism in Children and AdolescentsThe Hyperthyroidism of Polyostotic Fibrous Dysplasia — A Possible Autoimmune AetiologyThe McCune-Albright SyndromeThe Measurement of Serum Alkaline Phosphatase in Clinical MedicineClinical Utilization of Alkaline Phosphatase MeasurementsThe MeCune-Albright Syndrome 1 October 1974Volume 81, Issue 4Page: 561-561KeywordsAcromegalyDysplasiaHyperparathyroidismHyperthyroidismLesionsProlactinPubertySkull Issue Published: 1 October 1974 PDF DownloadLoading ...