Prospects for Immunotherapy of Human Cancer
Authors: LLOYD J. OLD
Journal: Annals of Internal Medicine (1968)

Editorials1 August 1968Prospects for Immunotherapy of Human CancerLLOYD J. OLD, M.D., EDWARD A. BOYSE, M.D.LLOYD J. OLD, M.D.Search for more papers by this author, EDWARD A. BOYSE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-2-393 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAfter a period of almost total eclipse, tumor immunology is again a thriving field of interest. The final recognition of tumor antigens, so long in coming, has profoundly influenced contemporary thought about cancer.To begin with, these antigens represent qualitative distinctions between cancer cells and normal cells, contrary to earlier views that no such differences exist. Secondly, detection of these antigens by a variety of techniques adapted for the purpose provides approaches to determining the cause of various cancers; this is particularly obvious in the case of antigens specified by oncogenic viruses, although there are other tumor antigens that, as...Bibliography ALEXANDER P, DELORME EJ, HAMILTON LD, and HALL JG: Effect of nucleic acids from immune lymphocytes on rat sarcomata. Nature (London) 213: 569, 1967. CrossrefMedlineGoogle Scholar BOYSE EA, OLD LJ, STOCKERT E, and SHIGENO N: Genetic origin of tumor antigens. Cancer Res.: 28: 1280, 1968. MedlineGoogle Scholar HELLSTRÖM KE and MÖLLER G: Immunological and immunogenetic aspects of tumor transplantation. Progr. Allerg. 9: 158, 1965. Google Scholar HUEBNER RJ: Manifestations of virus-specific antigens in virus-induced tumor cells. Theoretical and practical considerations. Canad. Cancer Conf. 6: 390, 1966. MedlineGoogle Scholar KLEIN G: Tumor antigens. Ann. Rev. Microbiol. 20: 223, 1966. CrossrefMedlineGoogle Scholar MATHÉ G, SCHWARZENBERG L, AMIEL JL, SCHNEIDER M, CATTAN A, and SCHLUMBERGER JR: The role of immunology in the treatment of leukemias and hematosarcomas. Cancer Res. 27: 2542, 1967. MedlineGoogle Scholar OLD LJ, BENACERRAF B, CLARKE DA, CARSWELL EA, and STOCKERT E: The role of the reticuloendothelial system in the host reaction to neoplasia. Cancer Res. 21: 1281, 1961. MedlineGoogle Scholar OLD LJ and BOYSE EA: Antigens of tumors and leukemias induced by viruses. Fed. Proc. 24: 1009, 1965. MedlineGoogle Scholar PREHN RT: Cancer antigens in tumors induced by chemicals. Ibid., p. 1018. Google Scholar SJÖGREN HO: Transplantation methods as a tool for detection of tumor-specific antigens. Progr. Exp. Tumor Res. 6: 289, 1965. CrossrefMedlineGoogle Scholar SOUTHAM CM: Evidence for cancer-specific antigens in man. Prog. Exp. Tumor Res. 9: 2, 1967. Google Scholar GERBER P and BIRCH SM: Complement-fixing antibodies in sera of human and nonhuman primates to viral antigens derived from Burkitt's lymphoma cells. Proc. Nat. Acad. Sci. 58: 478, 1967. CrossrefMedlineGoogle Scholar HENLE G and HENLE W: Immunofluorescence in cells derived from Burkitt's lymphoma. J. Bacteriol. 91: 1248, 1966. CrossrefMedlineGoogle Scholar KLEIN G, CLIFFORD P, KLEIN E, and STJERNSWÄRD J: Search for tumor specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction. Proc. Nat. Acad. Sci. 55: 1628, 1966. CrossrefMedlineGoogle Scholar OLD LJ, BOYSE EA, OETTGEN HF, DE HARVEN E, GEERING G, WILLIAMSON B, and CLIFFORD P: Precipitating antibody in human serum to an antigen present in cultured Burkitt's lymphoma cells. Proc. Nat. Acad. Sci. 56: 1699, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LLOYD J. OLD, M.D.; EDWARD A. BOYSE, M.D.Affiliations: Sloan-Kettering Institute for Cancer Research New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTumor ImmunotherapyCirculating Humoral Antibodies in CancerCellular responses to autologous breast cancer tissue:Correlation with stage and lymphoreticuloendothelial reactiveCytolytic effects of alloantiserum in patients with lymphoproliferative disordersDrug Therapy for Neoplastic Disease in AdultsALKYLATING AGENTS IN CLINICAL CANCER CHEMOTHERAPY 1 August 1968Volume 69, Issue 2Page: 393-397KeywordsAntigensBurkitt lymphomaCancer immunotherapyCellsImmunology ePublished: 1 December 2008 Issue Published: 1 August 1968 PDF downloadLoading ...