tbuckley/cabot-search huggingface dataset:
IDEBENONE IN FRIEDREICH ATAXIA CARDIOMYOPATHY: RESULTS FROM A 6 MONTHS PHASE III STUDY
Authors: Sarah J. Lagedrost, Martin St. John Sutton, Sean R. Regner, Lauren A. Seyer, Kimberly A. Schadt, Meryl S. Cohen, Gary M. Satou, Beth D. Kaufman, Susan L. Perlman, Christian Rummey, Thomas Meier, David R. Lynch
Journal: Journal of the American College of Cardiology (2011)
Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice
Authors: Manyu Li, Della Yee, Terry R. Magnuson, Oliver Smithies, Kathleen M. Caron
Journal: Journal of Clinical Investigation (2006)

Adrenomedullin (AM) is a multifunctional peptide vasodilator that is essential for life. Plasma AM expression dramatically increases during pregnancy, and alterations in its levels are associated with complications of pregnancy including fetal growth restriction (FGR) and preeclampsia. Using AM+/– female mice with genetically reduced AM expression, we demonstrate that fetal growth and placental development are seriously compromised by this modest decrease in expression. AM+/– female mice had reduced fertility characterized by FGR. The incidence of FGR was also influenced by the genotype of the embryo, since AM–/– embryos were more often affected than either AM+/– or AM+/+ embryos. We demonstrate that fetal trophoblast cells and the maternal uterine wall have coordinated and localized increases in AM gene expression at the time of implantation. Placentas from growth-restricted embryos showed defects in trophoblast cell invasion, similar to defects that underlie human preeclampsia and placenta accreta. Our data provide a genetic in vivo model to implicate both maternal and, to a lesser extent, embryonic levels of AM in the processes of implantation, placentation, and subsequent fetal growth. This study provides the first genetic evidence to our knowledge to suggest that a modest reduction in human AM expression during pregnancy may have an unfavorable impact on reproduction.
The Series of Consecutive Cases as a Device for Assessing Outcomes of Intervention
Authors: Lincoln E. Moses
Journal: New England Journal of Medicine (1984)

AN air of serving the common good clings to the process of reporting as general information the results of one's own extensive experience. Medicine enjoys a long tradition of such literature, and valuable results have sometimes ensued. Moreover, a large share of medical knowledge has been accumulated in just this way, through the publication of series of cases. The purpose of this paper is to examine the usefulness and limitations of series for assessing the safety and efficacy of medical interventions. Two historical examples initiate the discussion: the first demonstrates results with a new technique; the second compares outcomes between . . .
Case 26-1962
Authors: Edwin P. Maynard, Wallace A. Jones
Journal: New England Journal of Medicine (1962)

Presentation of CaseA sixty-two-year-old Hungarian man entered the hospital because of recurrent fever.During the month before admission there had been four episodes of fever, each lasting for several days, with elevations of the temperature to a maximum of 102°F., but with no chills, diaphoresis or headache. The first episode was accompanied by moderate nonradiating pain in the epigastrium and interscapular region of five days' duration. Bile was present in the urine on one occasion. Two weeks before entry a cholecystogram showed no filling of the gallbladder; the bromsulfalein retention at that time was 38 per cent. The patient . . .
Toxicities of Organs at Risk in the Mediastinal and Hilar Regions Following Stereotactic Body Radiotherapy for Centrally Located Lung Tumors
Authors: Shuichi Nishimura, Atsuya Takeda, Naoko Sanuki, Satoshi Ishikura, Yohei Oku, Yousuke Aoki, Etsuo Kunieda, Naoyuki Shigematsu
Journal: Journal of Thoracic Oncology (2014)
Serum transaminases and salicylate therapy.
Authors: T Iancu
Journal: BMJ (1972)

In contrast to the results of Dr. Alliott and others my patients showed a significant fall in Pao2 after salbutamol and a significant rise in Pao2 after isoprenaline/phenylephrine.FEV1 response was identical with both aerosols, the dosage employed being salbu- tamol 200 ,ug, isoprenaline 320 ,ug, and 480 jig phenylephrine.Within the limitations of the indirect Fick C02 method, cardiac output appeared to be equally affected by both preparations (a probably insignificant rise).The rise in Pao2 after isoprenaline/phenylephrine was accompanied by a fall in Paco2 and a reduction in VD/VE ratio.There was no evidence to suggest that the likelihood or degree of Pao2 fall with salbutamol
Gene expression of group II phospholipase A2 in intestine in ulcerative colitis.
Authors: M M Haapamaki, J M Gronroos, H Nurmi, K Alanen, M Kallajoki, T J Nevalainen
Journal: Gut (1997)

BACKGROUND: It has been suggested that phospholipase A2 (PLA2) has an essential role in the pathogenesis of inflammatory bowel diseases. AIMS: This study aimed at identifying cells in intestinal and mesenteric tissue samples that might express group II phospholipase A2 (PLA2-II) at the mRNA and enzyme protein levels in patients with ulcerative colitis. PATIENTS AND TISSUE SAMPLES: Tissue samples were obtained from the intestine, mesentery, skeletal muscle, and subcutaneous fat of six patients who underwent panproctocolectomy for severe ulcerative colitis. Mucosal biopsy specimens were obtained from the colon of another group of six patients with ulcerative colitis during routine diagnostic colonoscopies. Tissues from six patients without intestinal inflammatory diseases served as controls. METHODS: Tissue samples were studied by light microscopy, immunohistochemistry for PLA2-II enzyme protein, and in situ hybridisation and northern hybridisation for PLA2-II mRNA. RESULTS: PLA2-II mRNA and PLA2-II protein were detected in metaplastic Paneth cells in six patients and in the columnar epithelial cells of colonic mucosa in four out of six patients with active ulcerative colitis. Positive findings were less numerous in patients with mild ulcerative colitis. Only two out of six control patients had a weak positive signal for PLA2-II mRNA and one of these two patients had a weak positive immunoreaction for PLA2-II in columnar epithelial cells in the colonic mucosa. None of the control patients had metaplastic Paneth cells. CONCLUSIONS: Metaplastic Paneth cells and colonic epithelial cells synthesise PLA2-II in ulcerative colitis. The activity of the PLA2-II synthesis seems to be related to the degree of inflammation in the diseased bowel.
Intestinal Obstruction in a 55-Year-Old Man With Previous Thoracic Surgery (Extrapleural Plombage)
Authors: Charles F. Tate
Journal: JAMA (1980)

<h3>History</h3> A 55-year-old man came to the Miami Veterans Administration Hospital with a 48-hour history of crampy abdominal pain associated with nausea, vomiting, and diarrhea. The patient denied fever, genitourinary symptoms, or previous abdominal surgery. The patient's medical history was relevant in that he underwent bilateral collapse therapy with Lucite sphere plombage in 1946 for pulmonary tuberculosis. In January 1977, an empyema and bronchopleural fistula of the left hemithorax developed, requiring removal of 37 Lucite spheres and long-term antituberculous therapy. Review of systems indicated chronic, severe, nonproductive cough. Laboratory data at time admission disclosed a WBC count of 20,800/cu mm, with a shift to the left. Amylase, glucose, BUN, and electrolyte levels were within normal limits. Urinalysis revealed seven to ten WBCs per high-power field and an occasional RBC per high-power field. Admission posteroanterior chest films and anteroposterior films of the abdomen were obtained (Fig 1 and 2). <h3>Diagnosis</h3> Extrapleural
Oesophageal cancer and distilleries in Scotland.
Authors: I. W. Kemp, K. Clarke, L. J. Kinlen
Journal: BMJ (1992)

procedures.Negative comments principally cited time constraints with the new contract or expressed concern that practices might embark on these procedures with insufficient training in an attempt to save money.>9000 patients.Larger practices were looking favour- ably at the use of this instrument in primary care in response to NHS reforms.Finally, there was an expressed need for training in these procedures, though most existing users of sigmoidoscopy in this study had received appropriate training.This survey was supported by a
THE INFLUENCE OF CYTOCHROME P450 2C19*2 AND*17 GENOTYPE, DIPLOTYPE AND METABOLIZER STATUS ON PLATELET REACTIVITY IN PATIENTS ON MAINTENANCE CLOPIDOGREL THERAPY
Authors: Paul A. Gurbel, Udaya S. Tantry, Mark J. Antonino, Kevin P. Bliden, Ruth E. Pakyz, Alan R. Shuldiner
Journal: Journal of the American College of Cardiology (2010)
Involvement of von willebrand factor in thrombosis following asparaginase‐prednisone‐vincristine therapy for leukemia
Authors: Ching‐Hon Pui, Carl W. Jackson, Carolyn M. Chesney, Charles F. Abildgaard
Journal: American Journal of Hematology (1987)

Abstract To determine if factor VIII‐von Willebrand factor (vWF) complex is involved in the thrombosis associated with asparaginase‐prednisone‐vincristine induction therapy for acute lymphoblastic leukemia, plasma vWF was analyzed by sodium dodecyl sulfateagarose gel electrophoresis and crossed immunoelectrophoresis. Five patients with cerebral thrombosis were studied; all had a decreased platelet count following the complication. Sequential studies of three patients disclosed changes in plasma vWF multimer pattern. One patient who was studied serially from 2 days before to 1 day after the event, had an increase in unusually large plasma vWF multimers that disappeared after the complication. The other two patients who were studied at presentation subsequently showed a decrease in plasma large vWF multimers, especially remarkable in the patient having the sharpest decrease in platelet count. No appreciable difference in vWF multimer pattern, when compared to normal pooled plasma, was found in the remaining two patients who were only studied at presentation, or in the seven controls who received the same treatment but did not develop thrombosis. Crossed immunoelectrophoretic analyses of two patients tested disclosed a right shift of immunoprecipitin line in one and a left shift in the other. Our findings suggest that the thrombotic complications resulted from platelet agglutination by plasma vWF.
Moss' Radiation Oncology: Rationale, Technique, Results
Authors: Walter G. Gunn
Journal: JAMA (1994)

Forty years ago, one of the great teachers and clinicians in cancer care, Dr Juan del Regato, said, "Even if there are no further breakthroughs in cancer therapy, we have enough practical problems to last a lifetime." From that day to this, concerned clinicians have been nibbling around the edges of the cancer problem, developing techniques and approaches that incrementally cure and palliate many patients who could not be helped a generation ago. In the world of radiation oncology, there is much less morbidity now than there was then. The book at hand gives us a look at how far we've come and limns the many elements in cancer care. The emphasis is on radiation oncology, but the perspective is balanced. Broad principles are enunciated with enough treatment detail so that the reader will grasp what is up-to-date, but not so much in the way of detailed recipes that will
Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects
Authors: Ke Ren, Anand Dusad, Fang Yuan, Hongjiang Yuan, P. Edward Purdue, Edward V. Fehringer, Kevin L. Garvin, Steven R. Goldring, Dong Wang
Journal: Journal of Controlled Release (2013)
Phytochemical mimicry of reproductive hormones and modulation of herbivore fertility by phytoestrogens.
Authors: C L Hughes
Journal: Environmental Health Perspectives (1988)

Plants have physical and chemical mechanisms for defense from attack by animals. Phytochemical defenses that protect plants from attack by insects include antifeedants, insecticides, and insect growth regulators. Phytochemical options exist by which plants can modulate the fertility of the other major group of plant predators, vertebrate herbivores, and thereby reduce cumulative attacks by those herbivores. The success of such a defense depends upon phytochemical mimicry of vertebrate reproductive hormones. Phytoestrogens do mimic reproductive hormones and are proposed to be defensive substances produced by plants to modulate the fertility of herbivores.
DELAYED CONTRAST ENHANCEMENT ON CARDIAC MRI AND RISK OF CLINICALLY SIGNIFICANT VENTRICULAR ARRHYTHMIAS IN HYPERTROPHIC CARDIOMYOPATHY: A META-ANALYSIS OF OBSERVATIONAL STUDIES
Authors: Venkata Alla, Sushma Koneru, Madhu Reddy, Jessica Fernandes, Dhanunjaya Lakkireddy, Claire Hunter, Aryan Mooss
Journal: Journal of the American College of Cardiology (2012)
Treating preinfected wounds
Authors: A. G. Zermansky
Journal: BMJ (1969)

MBICA OHNAL coronary care.The patient with an apparently mild myocardial infarction is at as great a risk of developing fatal ventricular dysrhythmia as the patient with a clinically severe infarct.4In Newcastle the interval between the receipt of the call from the practitioner and the arrival of the coronary care team with the patient (mean 21 minutes) contrasts with the Belfast time (median 10 minutes).The inordinate delay may contribute to the lack of interest of the Newcastle practitioners in the scheme.Dr. Dewar and his colleagues indicate that only 420% of the Newcastle practitioners use the mobile unit and that the number is not increasing.A questionary conducted by one of us (Dr.Zaidi) in March 1969 indicated that 89% of the Belfast practitioners use the mobile scheme.Another important difference between the two schemes is that in Belfast only personnel who have gained experience in the hospital coronary care unit are allowed to go on the mobile team.We agree with Dr. Dewar and his colleagues that it is most important to have adequate inpatient coronary care facilities for reception of patients managed by a mobile unit.It should be stressed, however, that all the available data indicate that at least two-thirds of the deaths from myo- cardial infarction occur outside hospital and that therefore when problems of staffing exist priority should be given to staffing of the mobile unit.-Weare, etc.,
Long‐term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure
Authors: Athanasios Trikas, Charalambos Antoniades, Giorgos Latsios, Karmen Vasiliadou, Ioannis Karamitros, Dimitris Tousoulis, Costantinos Tentolouris, Christodoulos Stefanadis
Journal: European Journal of Heart Failure (2006)
Acute malaria in newborn infants.
Authors: N E Okeke
Journal: BMJ (1970)

from severe vomiting of late pregnancy.She was given intravenous fluids via the right cephalic vein using an Intracath Bard Davol catheter.Later the drip was leaking, therefore the catheter was withdrawn and adjusted.As this was still unsatisfactory a second infusion was set up.The first catheter was removed and found to be incomplete.X-rays were taken which showed the missing portion to have migrated through the superior vena cava into the right atrium.She was transferred to Hammersmith Hospital and treated firstly with intravenous fluid, anticoagulants, and antibiotics.
Effects of varying doses of spironolactone without and with nitrates on portal vein pressure and kidney function in partial portal vein ligated rats
Authors: M Van de Castelle, G Van Roey, F Nevens, J Fevery
Journal: Hepatology (1996)

The optimal dose of spironolactone to reduce portal vein pressure, alone or in combination with isosorbide-5-mononitrate (IsMn), has not been identified. We studied the effects of 8 days oral treatment with spironolactone, IsMn or both on portal pressure, plasma volume and renal sodium handling in rats with partial portal vein ligation. At daily doses of 0.33; 0.50; 1, and 1.50 mg/kg, spironolactone reduced portal pressure (all P < .05) as compared with placebo. Only the highest dose significantly lowered plasma volume (10.1 +/- 0.7 vs. 13.0 +/- 0.3 mL; P < .03) and enhanced urinary fractional sodium excretion (0.73 +/- 0.04 vs. 0.58 +/- 0.03%; P < .03) and the (Na+)/(K+) ratio in urine (0.43 +/- 0.04 vs. 0.30 +/- 0.03; P < .02). IsMn at doses of 0.25; 0.50, and 1 mg/kg decreased portal pressure (all P < .05) without a change in plasma volume but with a tendency (not significant) to lower fractional sodium excretion. IsMn impaired free water clearance at doses of 0.5 and 1 mg/kg (P < .05). Combinations of spironolactone 1 mg/kg with IsMn 0.5 or 1 mg/kg have no additive effect on portal pressure compared with spironolactone or IsMn alone. The higher the dose of IsMn in the combination, the more the natriuretic effect of spironolactone is opposed. Low doses of spironolactone are as effective as a higher dose to reduce portal pressure. This reduced portal pressure was independent of changes in plasma volume and diuretic effect, which suggests that spironolactone might have a direct vasoactive effect on the splanchnic circulation. To counteract sodium retention of nitrovasodilators, combination with high doses of spironolactone seems advantageous.
Science, medicine, and the future: Genetic epidemiology
Authors: J. Kaprio
Journal: BMJ (2000)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Genetic epidemiology Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Synthetic EthR inhibitors boost antituberculous activity of ethionamide
Authors: Nicolas Willand, Bertrand Dirié, Xavier Carette, Pablo Bifani, Amit Singhal, Matthieu Desroses, Florence Leroux, Eve Willery, Vanessa Mathys, Rebecca Déprez-Poulain, Guy Delcroix, Frédéric Frénois, Marc Aumercier, Camille Locht, Vincent Villeret, Benoit Déprez, Alain R Baulard
Journal: Nature Medicine (2009)
Familial Mediterranean fever associated pyrin mutations in Greece
Authors: K Konstantopoulos
Journal: Annals of the Rheumatic Diseases (2003)

<b>Objective:</b> To search for pyrin mutations associated with familial Mediterranean fever (FMF) in Greece. <b>Patients and methods:</b> 62 patients fulfilling the Tel Hashomer diagnostic criteria for definite (33) or probable (29) FMF diagnosis were studied. Eight point mutations of pyrin gene were tested by standard methods. Of the 62 patients tested, 48 were Greek, four were Jewish, seven were Armenian, and three were Arab. <b>Results:</b> 42 patients were found to be homozygotes for pyrin mutations; 11 patients were found to carry only one of the tested mutations; in nine patients no mutations were detected. <b>Conclusion:</b> Molecular detection of pyrin gene mutations seems useful in confirming suspected cases, and in detecting asymptomatic cases, of Mediterranean fever in Greece. It may also be used as a screening tool within affected families.
Scintigraphic Findings on Examination of the Multipartite Patella
Authors: CAROL L. COLLINGS
Journal: Clinical Nuclear Medicine (1994)

Bipartite or multipartite patella occurs in approximately 2–3% of the general population. In the setting of trauma, this entity may be confused with a fracture of the patella. The mechanism of injury, clinical symptomatology, and plain film findings are often helpful in distinguishing the two possibilities. However, cases do occur in which a fracture cannot be confidently excluded. This case demonstrates how scintigraphy may provide further clarification in this diagnostic dilemma.
Cyclosporin A (CyA) in primary Sjogren's syndrome: a double blind study.
Authors: A A Drosos, F N Skopouli, J S Costopoulos, C S Papadimitriou, H M Moutsopoulos
Journal: Annals of the Rheumatic Diseases (1986)

The efficacy and toxicity of cyclosporin A (CyA) were studied in a blind fashion in 20 patients with primary Sjögren9s syndrome (pSS). The dose of CyA or placebo was 5 mg/kg of body weight daily. Among the 20 patients, 10 received CyA and 10 placebo. The two groups were matched for age, sex, and disease duration. Patients treated with CyA improved in subjective xerostomia in comparison with patients treated with placebo. Subjective xerophthalmia and recurrent parotid gland enlargement did not differ in the two groups. No change in Schirmer9s test and stimulated parotid flow rate was observed in either group. In contrast, the histopathological lesion of patients treated with CyA remained unchanged in most of the patients, while in the placebo treated group the lesion deteriorated. Laboratory parameters did not change before or after treatment in either group. The only clinical side effect observed in the CyA treated group was hypertrichosis.
Mitochondrial metabolism and substrate competition in the aging Fischer rat heart
Authors: J. B McMillin, G. E Taffet, H. Taegtmeyer, E. K Hudson, C. A Tate
Journal: Cardiovascular Research (1993)

Journal Article Mitochondrial metabolism and substrate competition in the aging Fischer rat heart Get access Jeanie B McMillin, Jeanie B McMillin Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, the University of Texas Health Science Center, Houston, Texas 77030, USA: J B McMillin, G E Taffet, H Taegtmeyer, E K Hudson, C A Tate. Correspondence to Dr McMillin. Search for other works by this author on: Oxford Academic PubMed Google Scholar George E Taffet, George E Taffet Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, the University of Texas Health Science Center, Houston, Texas 77030, USA: J B McMillin, G E Taffet, H Taegtmeyer, E K Hudson, C A Tate. Search for other works by this author on: Oxford Academic PubMed Google Scholar Heinrich Taegtmeyer, Heinrich Taegtmeyer Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, the University of Texas Health Science Center, Houston, Texas 77030, USA: J B McMillin, G E Taffet, H Taegtmeyer, E K Hudson, C A Tate. Search for other works by this author on: Oxford Academic PubMed Google Scholar Edgar K Hudson, Edgar K Hudson Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, the University of Texas Health Science Center, Houston, Texas 77030, USA: J B McMillin, G E Taffet, H Taegtmeyer, E K Hudson, C A Tate. Search for other works by this author on: Oxford Academic PubMed Google Scholar Charlotte A Tate Charlotte A Tate Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, the University of Texas Health Science Center, Houston, Texas 77030, USA: J B McMillin, G E Taffet, H Taegtmeyer, E K Hudson, C A Tate. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 12, December 1993, Pages 2222–2228, https://doi.org/10.1093/cvr/27.12.2222 Published: 01 December 1993
A Study of 212 Home Accidents
Authors: Jerome J. DeCosse
Journal: New England Journal of Medicine (1953)

ACCIDENTS are a problem of increasing importance to modern society. During 1950, there were 90,000 deaths in the United States1 from this cause. Accidents were the fourth leading cause of death among the total population of Minnesota during 1950, and the most frequent cause of death2 among persons one to thirty-four years of age, being responsible for more deaths than neoplastic diseases, convulsions and diseases of the central nervous system, heart disease and rheumatic fever, congenital malformations, and pneumonia and influenza combined.2 The home is the most frequent site of accident in the United States, 27,500 deaths and 4,100,000 injuries . . .