tbuckley/cabot-search huggingface dataset:
<i>TEL/AML1</i> rearrangement and the prognostic significance in childhood acute lymphoblastic leukemia in Hong Kong
Authors: Kam Sze Tsang, Chi Kong Li, Ki Wai Chik, Matthew Ming Kong Shing, Wai Chiu Tsoi, Margaret Heung Ling Ng, Tai Tap Lau, Yonna Leung, Patrick Man Pan Yuen
Journal: American Journal of Hematology (2001)

The TEL/AML1 rearrangement has been implicated as an independent good prognostic factor in pediatric acute lymphoblastic leukemia (ALL). We examined TEL/AML1 using nested reverse-transcription polymerase chain reaction (RT-PCR) and correlated TEL/AML1 with cytogenetics and immunophenotypes in 75 consecutively analyzed Chinese children with ALL in Hong Kong. TEL/AML1 was detected in 17.9% (12/67) B-lineage ALL at diagnosis but not in 8 T-ALL children or in 34 adults with ALL. E2A/PBX1, MLL/AF4, and BCR/ABL were not found in TEL/AML1+ patients. Coexpression of cross-lineage antigens was associated with TEL/AML1 gene fusion (p = 0.032), with CD13 in 80% (4/5) TEL/AML1+ cohort. Chromosomal abnormalities were demonstrated in 50% of the TEL/AML1+ ALL; however, a cryptic t(12;21) was not detected in these cases. Hyperdiploidy of 47-48 chromosomes was encountered in 25%. Deletion of 12p resulting in the loss of the normal allele of TEL and nonspecific del(6q) were noted in 8% (1/12) and 25% (3/12) of the TEL/AML1+ children, respectively. Rapid clearance of TEL/AML1 was noted in 50% of the patients on completion of the induction therapy; however, 16.7% (2/12) TEL/AML1+ ALL relapsed at a mean of 48.6 months from diagnosis (25 months off-therapy). The incidence of relapses of TEL/AML1+ ALL was comparable to that at diagnosis in B-lineage ALL (14.3% [2/14] vs. 17.9% [12/67], p > 0.05). The relapse rate in TEL/AML1+ ALL was similar to that of TEL/AML1- ALL (16.7% [2/12] vs. 20.6% [13/63], p > 0.05). The duration of first complete remission in TEL/AML1+ ALL was significantly longer as compared to TEL/AML1- ALL (mean [range] in month: 48.6 [47.2 - 50] vs 14.6 [2.9 - 42.3], p < 0.0001). Irrespective of TEL/AML1 rearrangement, the probabilities of the five-year overall survival and the event-free survival of patients were comparable (overall survival: 100% vs. 72.3%, p = 0.166 and event-free survival: 60% vs. 56.2%, p = 0.343). Our data would not suggest a less aggressive treatment regimen for TEL/AML1+ ALL.
TARDY HONORS TO AESCULAPIUS
Authors: Edwin B. Frost
Journal: JAMA (1928)

<h3>To the Editor:</h3> —It recently came to my attention that the worthy patron of medicine, Aesculapius, by some strange oversight, failed to have his name given to any celestial object, although he was promised a place among the stars by Zeus, yielding to the request of Apollo. Accordingly, my colleague, Prof. George Van Biesbroeck of this observatory, discoverer of some unnamed asteroids, has accepted my suggestion and we have christened number 1027 of the large family of asteroids with the name Aesculapius. This object circulates between the orbits of Mars and Jupiter, at an average distance of 294 million miles from the sun, in a period of 5.62 years. At the nearest point of its orbit to that of the earth, its distance is 163 million miles from us and it is of the fourteenth magnitude. Doctors wishing to consult their Patron Saint will have to use a pretty good
Achalasia of the Oesophagus in Children
Authors: R. W. Raven
Journal: BMJ (1961)

MUMPS ARTHRITIS BuTiCsHIf mumps were considered in the differential diagnosis of arthritis in the young, especially in males, we suspect that more cases would be recognized.Numerous cases of infection with mumps virus have been recorded without parotitis; among these are pancreatitis (Friedjung, 1928), orchitis (Connolly, 1953), and meningitis (Van Rooyen and Rhodes, 1948), the diagnosis being made on the basis of a significant rise in agglutination titres.We can find no reference to arthritis sine parotitis in the literature, but suggest that estimation of viral titres and attempts to grow virus from an affected joint may perhaps lead to recognition of this condition.
Coffee, tea, and plasma cholesterol: the Jerusalem Lipid Research Clinic prevalence study.
Authors: J Yudkin
Journal: BMJ (1985)

currently being operated on have retractile testes, but if this is not the case there must have been a substantial increase in the incidence of undescended testis over the past 20 years.There are no data available with which to resolve this ques- tion.One way to settle the issue would be to repeat Scorer's original studies.We are collaborating with the departments of obstetrics and gynaecology, surgery, and paediatrics at the John Radcliffe Hospital to do such a study.We have so far examined a cohort of more than 2500 newborn boys and the results of the first year of the study will be available in about six months.
Simultaneous occurrence of gastric lipoma and early gastric cancer
Authors: Tsutomu Namikawa, Eri Munekage, Hiroshi Mizuta, Michiya Kobayashi, Toshiji Saibara, Kazuhiro Hanazaki
Journal: Endoscopy (2014)

An asymptomatic 72-year-old man underwent a screening esophagogastroduodenoscopy (EGD) at our hospital. The EGD showed a sessile polypoid lesion with a smooth surface in the greater curvature of the gastric antrum, which was diagnosed as a submucosal tumor ([Fig. 1 a]). A second slightly elevated lesion with a shallow depression was observed in the greater curvature of the lower gastric body near the polypoid lesion ([Fig. 1b]). This was confirmed on biopsy to be a well-differentiated tubular adenocarcinoma. The borders of this lesion became distinct when indigo carmine dye was used in a chromoendoscopy ([Fig. 1 c]). Abdominal contrast-enhanced computed tomography (CT) revealed a well-circumscribed, low-density mass in the wall of the gastric antrum ([Fig. 2]).
Splanchnic Transplantation
Authors: James W. Williams
Journal: JAMA (1989)

Two infants with short-bowel syndrome and liver failure associated with obligatory parenteral nutrition received a composite allograft that consisted of en bloc liver, stomach, duodenum, pancreas, jejunum, and ileum. Solutions to the fatal complications in the first case resulted in a functioning composite splanchnic system in the second case. Despite a number of early complications, the small intestine and liver developed near-normal function until a monoclonal, malignant, B-cell lymphoproliferative disorder appeared. The analysis of these two cases supports three summary observations: the operative procedure can be safely performed in a metabolically compromised infant; intestinal allograft rejection, in this model, is controllable with existing immunosuppressive drugs; and this procedure appears to be associated with a uniquely high incidence of lymphoma. Since transplantation is a feasible solution to this devastating infantile disease, further development of this therapy must incorporate means of preventing lymphoma. (<i>JAMA</i>. 1989;261:1458-1462)
A rare case of hypalbuminaemic oedema
Authors: M Merger
Journal: Gut (2005)

<h3>ABSTRACT</h3> <h3>Background</h3> This retrospective cohort study aims to define the clinical findings and outcomes of every patient admitted to a district general hospital in Surrey with COVID-19 in March 2020, providing a snapshot of the first wave of infection in the UK. This study is the first detailed insight into the impact of frailty markers on patient outcomes and provides the infection rate among healthcare workers. <h3>Methods</h3> Data were obtained from medical records. Outcome measures were level of oxygen therapy, discharge and death. Patients were followed up until 21 April 2020. <h3>Results</h3> 108 patients were included. 34 (31%) died in hospital or were discharged for palliative care. 43% of patients aged over 65 died. The commonest comorbidities were hypertension (49; 45%) and diabetes (25; 23%). Patients who died were older (mean difference ±SEM, 13.76±3.12 years; p&lt;0.0001) with a higher NEWS2 score (median 6, IQR 2.5–7.5 vs median 2, IQR 2–6) and worse renal function (median differences: urea 2.7 mmol/L, p&lt;0.01; creatinine 4 μmol/L, p&lt;0.05; eGFR 14 mL/min, p&lt;0.05) on admission compared with survivors. Frailty markers were identified as risk factors for death. Clinical Frailty Scale (CFS) was higher in patients over 65 who died than in survivors (median 5, IQR 4–6 vs 3.5, IQR 2–5; p&lt;0.01). Troponin and creatine kinase levels were higher in patients who died than in those who recovered (p&lt;0.0001). Lymphopenia was common (median 0.8, IQR 0.6–1.2; p&lt;0.005). Every patient with heart failure died (8). 26 (24%) were treated with continuous positive airway pressure (CPAP; median 3 days, IQR 2–7.3) and 9 (8%) were intubated (median 14 days, IQR 7–21). All patients who died after discharge (4; 6%) were care home residents. 276 of 699 hospital staff tested were positive for COVID-19. <h3>Conclusions</h3> This study identifies older patients with frailty as being particularly vulnerable and reinforces government policy to protect this group at all costs.
Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles
Authors: Emma L Clayton, Nancy Sue, Karen J Smillie, Timothy O'Leary, Nicolai Bache, Giselle Cheung, Adam R Cole, David J Wyllie, Calum Sutherland, Phillip J Robinson, Michael A Cousin
Journal: Nature Neuroscience (2010)
Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-κB essential modulator deficiency
Authors: Sung-Yun Pai, Ofer Levy, Haifa H. Jabara, Jonathan N. Glickman, Liat Stoler-Barak, Jessica Sachs, Samuel Nurko, Jordan S. Orange, Raif S. Geha
Journal: Journal of Allergy and Clinical Immunology (2008)
The impact of total body irradiation on the outcome of patients with follicular lymphoma treated with autologous stem-cell transplantation in the modern era: a retrospective study of the EBMT Lymphoma Working Party
Authors: I. El-Najjar, A. Boumendil, J.J. Luan, R. Bouabdallah, K. Thomson, M. Mohty, P. Colombat, P. Biron, H. Tilly, M. Pfreundschuh, C. Cordonnier, A. Sureda, J.Y. Cahn, J.P. Vernant, J. Gribben, G. Cook, A.P. Haynes, A. Ferrant, H. Finel, S. Montoto, P. Dreger
Journal: Annals of Oncology (2014)
THE ETIOLOGY AND TREATMENT OF OBLIQUE INGUINAL HERNIA
Authors: R. W. Murray
Journal: BMJ (1906)

swelling, tense and grey, about J in. in diameter.This enlargement felt so tense that it seemed ready to burst, and great care was taken to prevent this.The distal end was now soilght for, and was seen to be about an inch in length, extremely like a thin-walled vein, and dividing near its termi- nation into three smaller vessels, which opened separately at the junction of the internal jugular with the subelavian vein.No fluid issued from this portion of the duct, but on passing a grooved director through it, and along one of the terminal branches into the innominate vein, blood flowed along the groove.On removing the director this bleeding ceased, thereby showing the action of the valves of the duct.This end of the duct was also ligatured, although at the time of operation no leakage appeared likely to occur.The remaining glands were now removed, the wound was stitched up by a continuous silkworm gut suture, and a glass drainage tube was inserted for forty-eight hours.On account of the risk of the rupture of the proximal end of the ligatured duct, 'the patient was kept on the lowest possible diet for a few days, and all unnecessary movements were interdicted, so as to diminish as much as possible the pressure and flow in the occluded duct pending the establishment of the collateral circulation.The dressings were inspected at frequent inter- vals in order to ascertain whether leakage had taken place through the drainage tube, in the event of which I proposed to open up the wound and again deal with the duct.The patient fortunately did not vomit after the operation, and made an uninterrupted recovery without any swelling or sign of leakage.She was weighed on the fourth day and each week for seven weeks.She lost 4 oz.during the first week, gained over 4 lb. the second, 7 lb.the third, nearly 2 lb. the fourth, under 1 lb. the fifth, 2 lb. the sixth, and practically nothing the seventh week, so that now she is nearly 1 st.heavier than when she was operated on.A blood count by Dr. Houston on the eighth day after the operation was as follows: Poly- morphonuclear leucocytes, 72 per cent.; small lymphocytes, 23 per cent.; large lymphocytes, 4 per cent.; and eosinophiles,
THE DANISH TREATMENT OF SCABIES
Authors: ARTHUR M. GREENWOOD
Journal: JAMA (1924)

In 1920, Dr. Svend Lomholt, 1 Copenhagen, described a twenty-four hour method of treatment of scabies. This treatment was first used in Copenhagen, in 1911, by Professor Ehlers, and the ointment was made by Mr. Marcussen, a chemist at the hospital of the city of Copenhagen.  We have been using this treatment at the skin department of the Massachusetts General Hospital.  The directions for the preparation of the ointment are given in the original article. Mr. Godsoe, pharmacist at the Massachusetts General Hospital, has kindly furnished the following rather more detailed directions which he has used in making up our supply:   One kilogram of sublimed sulphur is mixed with 2 kg. of 50 per cent, solution of potassium hydroxid (as free from water as can be obtained). Gentle heat is applied until reaction ceases and the solution becomes clear. When the process is complete, one should be sure that the
Robust PEGylated hyaluronic acid nanoparticles as the carrier of doxorubicin: Mineralization and its effect on tumor targetability in vivo
Authors: Hwa Seung Han, Jungmin Lee, Hyun Ryoung Kim, Su Young Chae, Minwoo Kim, Gurusamy Saravanakumar, Hong Yeol Yoon, Dong Gil You, Hyewon Ko, Kwangmeyung Kim, Ick Chan Kwon, Jae Chan Park, Jae Hyung Park
Journal: Journal of Controlled Release (2013)
TUMORS OF THE MAMMARY GLAND.
Authors: W.L. RODMAN
Journal: JAMA (1895)

There is no surgical subject the literature of which is less satisfactory, than that of mammary tumors. This is not due to a lack of writers, but rather to their contradictory positions. In the first place the nomenclature of the subject could not well be in a worse condition. The American, English, German and French schools each has a classification peculiar to itself. The general reader finds himself hopelessly at sea, in endeavoring to reconcile the teachings of standard authors. The only true classification—one based upon accurate pathology—has not been followed. Growths considered by some as benign, are by others treated as malignant. This confusion, noticeable as it is with malignant neoplasms, is much greater with benign affections. Take, for instance, the most common of benign tumors, and we find it described under the same name by only two recognized authors. It has at least a dozen names. The fibroma
Transient vascularization of transplanted human adult–derived progenitors promotes self-organizing cartilage
Authors: Takanori Takebe, Shinji Kobayashi, Hiromu Suzuki, Mitsuru Mizuno, Yu-Min Chang, Emi Yoshizawa, Masaki Kimura, Ayaka Hori, Jun Asano, Jiro Maegawa, Hideki Taniguchi
Journal: Journal of Clinical Investigation (2014)

Millions of patients worldwide are affected by craniofacial deformations caused by congenital defects or trauma. Current surgical interventions have limited therapeutic outcomes; therefore, methods that would allow cartilage restoration are of great interest. A number of studies on embryonic limb development have shown that chondrogenesis is initiated by cellular condensation, during which mesenchymal progenitors aggregate and form 3D structures. Here, we demonstrated efficient regeneration of avascular elastic cartilage from in vitro-grown mesenchymal condensation, which recapitulated the early stages of chondrogenesis, including transient vascularization. After transplantation of vascularized condensed progenitors into immunodeficient mice, we used an intravital imaging approach to follow cartilage maturation. We determined that endothelial cells are present inside rudimentary cartilage (mesenchymal condensation) prior to cartilage maturation. Recreation of endothelial interactions in culture enabled a recently identified population of adult elastic cartilage progenitors to generate mesenchymal condensation in a self-driven manner, without requiring the support of exogenous inductive factors or scaffold materials. Moreover, the culture-grown 3D condensed adult-derived progenitors were amenable to storage via simple freezing methods and efficiently reconstructed 3D elastic cartilage upon transplantation. Together, our results indicate that transplantation of endothelialized and condensed progenitors represents a promising approach to realizing a regenerative medicine treatment for craniofacial deformations.
ABC of Sports Medicine
Authors: J. Rushton
Journal: BMJ (1995)

Ed Greg Mclatchie, Mark Harries, John King, Clyde Williams BMJ Publishing Group, £14.95, pp 109 ISBN 0 7279 0844 8

Many doctors, if the demands on their time permit, will play the occasional game of golf. Most will remember team games played at school and college, but their experience of other sports may be limited.

Furthermore, general practitioners may have had little or no training in sports medicine. Confronted with an athlete attending the surgery with an injury or medical condition, the doctor may lack confidence in dealing with this apparently …
U.S. experience of immunomodulators in the treatment of psoriasis
Authors: R. Weller
Journal: British Journal of Dermatology (2005)

Journal Article U.S. experience of immunomodulators in the treatment of psoriasis R. Weller R. Weller Department of Dermatology, Edinburgh University, Lauriston Building, Lauriston Place, Edinburgh EH3 9HA, U.K. E‐mail: r.weller@ed.ac.uk; rweller@staffmail.ed.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 4, 1 April 2005, Pages 817–818, https://doi.org/10.1111/j.1365-2133.2005.06495.x Published: 01 April 2005
Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis
Authors: Marthe T Maehlen, Inge C Olsen, Bettina K Andreassen, Marte K Viken, Xia Jiang, Lars Alfredsson, Henrik Källberg, Boel Brynedal, Fina Kurreeman, Nina Daha, Rene Toes, Alexandra Zhernakova, Javier Gutierrez-Achury, Paul I W de Bakker, Javier Martin, María Teruel, Miguel A Gonzalez-Gay, Luis Rodríguez-Rodríguez, Alejandro Balsa, Till Uhlig, Tore K Kvien, Benedicte A Lie
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objective</h3> Certain HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) are associated with rheumatoid arthritis (RA). Our objective was to examine the combined effect of these associated variants, calculated as a cumulative genetic risk score (GRS) on RA predisposition, as well as the number of autoantibodies (none, one or two present). <h3>Method</h3> We calculated four GRSs in 4956 patients and 4983 controls from four European countries. All four scores contained data on 22 non-HLA-risk SNPs, and three scores also contained HLA-DRB1 genotypes but had different HLA typing resolution. Most patients had data on both rheumatoid factor (RF) and anti-citrullinated proteins antibodies (ACPA). The GRSs were standardised (std.GRS) to account for population heterogeneity. Discrimination between patients and controls was examined by receiveroperating characteristics curves, and the four std.GRSs were compared across subgroups according to autoantibody status. <h3>Results</h3> The std.GRS improved its discriminatory ability between patients and controls when HLA-DRB1 data of higher resolution were added to the combined score. Patients had higher mean std.GRS than controls (p=7.9×10<sup>−156</sup>), and this score was significantly higher in patients with autoantibodies (shown for both RF and ACPA). Mean std.GRS was also higher in those with two versus one autoantibody (p=3.7×10<sup>−23</sup>) but was similar in patients without autoantibodies and controls (p=0.12). <h3>Conclusions</h3> The GRS was associated with the number of autoantibodies and to both RF and ACPA positivity. ACPA play a more important role than RF with regards to the genetic risk profile, but stratification of patients according to both RF and ACPA may optimise future genetic studies.
NOTES ON CURETTAGE.WITH REPORT OF A CASE OF ACCIDENTAL PERFORATION OF THE UTERUS.
Authors: A. P. STONER
Journal: JAMA (1904)

At one time the curette was offered as a panacea for nearly every uterine disorder. Indeed, it was often ruthlessly used on the most insignificant provocation, where Nature, with the assistance of a little general treatment, would have sufficed to cure. Retained secundines following abortion and miscarriage may usually be readily removed with the finger. It is not advisable, however, to immediately dilate the uterus in order that the finger may be employed, for in cases in which the organ has become contracted to such an extent that instrumental dilatation becomes necessary, the amount of débris is found to be small, and may readily be removed with the curette. On the other hand, when there is an abundance of foreign tissue in the uterus, its removal with the curette is attended with much difficulty, and one is never sure when the cavity has been emptied. I recall one instance of an incomplete abortion in which, after having apparently emptied the uterus with the curette, I was about to insert the packing (which was then the practice), when I found that my finger
Epidemic Pleurodynia in Texas
Authors: Robert J. Huebner, Joe A. Risser, Joseph A. Bell, Edward A. Beeman, Paul M. Beigelman, James C. Strong
Journal: New England Journal of Medicine (1953)

EPIDEMIC pleurodynia (Bornholm disease, epidemic myalgia, devil's grippe), first described by Daae1 and Homann2 in Norway in 1872 and by Finsen3 in Iceland in 1874, has been reported with ever-increasing frequency since the appearance of the classic monograph by Sylvest4 in 1933. Although a virus etiology was postulated by many observers, attempts to isolate an infectious agent of likely etiologic significance were unsuccessful until recently.In 1949 Curnen, Shaw and Melnick,5 reporting the occurrence of the Connecticut 5 Coxsackie virus (classified by Dalldorf as Bl) in patients with diagnoses of nonparalytic poliomyelitis or aseptic meningitis, noted the recovery of the . . .
Boric Acid Poisoning in an Infant
Authors: John P. Connelly, John D. Crawford, Albert H. Soloway
Journal: New England Journal of Medicine (1958)

THIS report is made to re-emphasize the hazards of using boric acid as an antiseptic and leaving drugs in dangerous areas. It also provides an opportunity for comparison of quantitative observations in a case of conservatively treated boric acid poisoning with published data obtained in a case treated by exchange transfusion.1 Case ReportJ.R. (M.G.H. 993545), a 9-day-old male infant, was admitted from a nearby hospital after an unremarkable pregnancy and delivery. At 5 days he was circumcised and discharged from the hospital. The parents were advised to dust the circumcision with boric acid powder. A 0.5-kg. (1-pound) can of . . .