Sudden Jaundice with Isolated Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies
Authors: Edward L. Krawitt
Journal: Annals of Internal Medicine (1999)

Letters16 November 1999Sudden Jaundice with Isolated Atypical Perinuclear Antineutrophil Cytoplasmic AntibodiesEdward L. Krawitt, MDEdward L. Krawitt, MDUniversity of Vermont College of Medicine; Burlington, VT 05405-0068 (Krawitt)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-10-199911160-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 42-year-old computer programmer presented with jaundice and reported 2 weeks of nonspecific symptoms. Jaundice and hepatomegaly were present. The liver measured 17 cm in the right midclavicular line, and the spleen was not palpable. Serum bilirubin level was 257 µmol/L (15.0 mg/dL) conjugated and 29 µmol/L (1.7 mg/dL) unconjugated, albumin level was 4.2 g/L, globulin level was 2.8 g/L, alanine aminotransferase level was 2800 U/L, aspartate aminotransferase level was 2230 U/L, alkaline phosphatase level was 260 U/L, and prothrombin time was 12.9 seconds. Results of tests for hepatitis A antibody, hepatitis B markers, cytomegalovirus antibody, and ...References1. Semrad CE, Terjung B, Worman HJ. Antineutrophil cytoplasmic and other autoantibodies in primary sclerosing cholangitis. In: Krawitt EL, Wiesner RH, Nishioka M, eds. Autoimmune Liver Diseases. 2d ed. Amsterdam: Elsevier Science B.V.; 1998:305-20. Google Scholar2. Targan SR, Landers C, Vidrich A, Czaja AJ. High-titer antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis. Gastroenterology. 1995;108:1159-66. CrossrefMedlineGoogle Scholar3. Zauli D, Ghetti S, Grassi A, Descovich C, Cassani F, Ballardini G, et al . Anti-neutrophil cytoplasmic antibodies in type 1 and 2 autoimmune hepatitis. Hepatology. 1997;25:1105-7. CrossrefMedlineGoogle Scholar4. Ohana M, Okazaki K, Hajiro K, Uchida K. Antilactoferrin antibodies in autoimmune liver diseases. Am J Gastroenterol. 1998;93:1334-9. CrossrefMedlineGoogle Scholar5. Terjung B, Herzog V, Worman HJ, Gestmann I, Bauer C, Sauerbruch T, et al . Atypical antineutrophil cytoplasmic antibodies with perinuclear fluorescence in chronic inflammatory bowel diseases and hepatobiliary disorders colocalize with nuclear lamina proteins. Hepatology. 1998;28:332-40. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Vermont College of Medicine; Burlington, VT 05405-0068 (Krawitt) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRole of Autoimmunity in Patients Transplanted for Acute Liver Failure of Unknown Origin: A Clinical and Graft Biopsy AnalysisClinical Presentation and DiagnosisAutoimmune Hepatitis 16 November 1999Volume 131, Issue 10Page: 796KeywordsAntibodiesAntigensAutoantibodiesAutoimmune hepatitisLiverLiver fibrosisSmooth musclesSoftware toolsSpleenUlcerative colitis Issue Published: 16 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...