tbuckley/cabot-search huggingface dataset:
High-dose mitoxantrone + melphalan (MITO/L-PAM) as conditioning regimen supported by peripheral blood progenitor cell (PBPC) autograft in 113 lymphoma patients: high tolerability with reversible cardiotoxicity
Authors: C Tarella, F Zallio, D Caracciolo, A Cuttica, P Corradini, P Gavarotti, M Ladetto, V Podio, A Sargiotto, G Rossi, AM Gianni, A Pileri
Journal: Leukemia (2001)
Spinal Cord Stimulation Alleviates Motor Deficits in a Primate Model of Parkinson Disease
Authors: Maxwell B. Santana, Pär Halje, Hougelle Simplício, Ulrike Richter, Marco Aurelio M. Freire, Per Petersson, Romulo Fuentes, Miguel A.L. Nicolelis
Journal: Neuron (2014)
Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population #
Authors: Amalia Gastaldelli, Michaela Kozakova, Kurt Hφjlund, Allan Flyvbjerg, Angela Favuzzi, Asimina Mitrakou, Beverley Balkau
Journal: Hepatology (2009)

Abstract Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic clamp), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of FL was estimated using the fatty liver index (FLI; &gt;60, likelihood &gt;78% presence FL; FLI &lt;20 likelihood &gt;91% absence of FL). Subjects were divided into three groups: G1: FLI &lt;20 (n = 608); G3: FLI &gt;60 (n = 234), G2: intermediate group (n = 465). Compared to G1, G3 included more men (70% versus 24%) and people with impaired glucose tolerance (23% versus 5%). IMT increased with FLI (G3 = 0.64 ± 0.08 versus G1 = 0.58 ± 0.08 mm, P &lt; 0.0001). FLI was associated with increased CHD risk ( r = 0.48), low-density lipoprotein cholesterol ( r = 0.33), alanine aminotransferase ( r = 0.48), aspartate aminotransferase ( r = 0.25), systolic blood pressure ( r = 0.39) and IMT ( r = 0.30), and reduced insulin sensitivity ( r = −0.43), high-density lipoprotein cholesterol ( r = −0.50), adiponectin ( r = −0.42), and physical activity ( r = −0.16, all P &lt; 0.0001). The correlations hold also in multivariate analysis after adjusting for age, gender, and recruiting center. Conclusion: In middle-age nondiabetic subjects, increased IMT, CHD risk, and reduced insulin sensitivity are associated with high values of FLI. (Hepatology 2009.)
Alpha_1-Antitrypsin Deficiency and Pancreatic Fibrosis
Authors: H. J. FREEMAN
Journal: Annals of Internal Medicine (1976)

A 39-year-old woman with homozygous ZZ alpha1-antitrypsin deficiency was found to have pancreatic fibrosis in addition to the recognized pulmonary and hepatic abnormalities. Pancreatic exocrine function was normal but endocrine studies showed glucose intolerance. Pancreatic fibrosis may be another manifestation of alpha1-antitrypsin deficiency.
CHRONIC FOCAL INFECTION AS A CAUSATIVE FACTOR IN CHRONIC ARTHRITIS
Authors: FRANK BILLINGS
Journal: JAMA (1913)

I presented a paper<sup>1</sup>on this subject in January, 1912. The study of the subject has been vigorously carried on since that date. Altogether seventy patients suffering from arthritis deformans have been investigated and treated in the Presbyterian Hospital under the auspices of the Otho S. A. Sprague Institute and the Dane Billings Memorial Fellowship in the Department of Medicine of Rush Medical College. This clinical research has confirmed the principles announced in the first paper. It has been found that the focal disease was usually located in the head. Most frequently this was a chronic streptococcus focus of the faucial tonsils; but chronic alveolar abscess and chronic sinusitis due to streptococcus infection were an occasional cause. In monarticular osteo-arthritis of the hip especially, chronic hypertrophic prostatitis with residual urine, chronic cystitis and infection with the colon bacillus seemed to be an etiologic factor. There can be no question
Taxol: A Novel Investigational Antimicrotubule Agent
Authors: E. K. Rowinsky, L. A. Cazenave, R. C. Donehower
Journal: JNCI Journal of the National Cancer Institute (1990)

Microtubules are among the most strategic subcellular targets of anticancer chemotherapeutics. Despite this fact, new antimicrotubule agents that possess unique mechanisms of cytotoxic action and have broader antineoplastic spectra than the vinca alkaloids have not been introduced over the last several decades—until the recent development of taxol. Unlike classical antimicrotubule agents like colchicine and the vinca alkaloids, which induce depolymerization of microtubules, taxol induces tubulin polymerization and forms extremely stable and nonfunctional microtubules. Taxol has demonstrated broad activity in preclinical screening studies, and antineoplastic activity has been observed in several classically refractory tumors. These tumors include cisplatin-resistant ovarian carcinoma in phase II trials and malignant melanoma and non-small cell lung carcinoma in phase I studies. Taxol's structural complexity has hampered the development of feasible processes for synthesis, and its extreme scarcity has limited the use of a conventional, broad-scale screening approach for evaluation of clinical antitumor activity. However, taxol's unique mechanism of action, its spectrum of preclinical antitumor activity, and tumor responses in early clinical trials have generated renewed interest in pursuing its development. [J Natl Cancer Inst 82: 1247–1259, 1990]
Walking the Black Dog
Authors: Christopher L Manning
Journal: BMJ (2007)

Parker is chief executive of the Black Dog Institute, not exactly a non-hyperbolic term for “an educational, research and clinical facility offering specialist expertise in mood disorders.”1 2 Perhaps one of the reasons why people like me who walk the Black Dog become so endlessly frustrated is that those who apparently stand for greater understanding of, and help for, folks like me, seemingly do very little to help the public and …
Abstract 2297: The evidence of glioblastoma heterogenity.
Authors: Akio Soeda, Akira Hara, Takahiro Kunisada, Toru Iwama
Journal: Cancer Research (2013)

Abstract Gliomas are composed of heterogeneous combinations of cells, with different phenotypic characteristics and different proliferative potentials; however, there is no convincing evidence that only the single glioma stem cells (GSC) could be representative of patient tumor and which cell type were the root for tumor growth. Because most tumors have a clonal origin, GSCs must give rise to phenotypically diverse progenies, including matured GSCs with indefinite self-renewing potential, as well as differentiated cancer cells with limited proliferative potential. To investigate the cellular origin of population diversity, we established 4 subclones from a glioblastoma patient. These subclones were subsequently propagated and analyzed. All clones expressed stem cell makers (nestin, sox2, musashi) heterogeneously. The morphology, self-renewal and proliferative capacities of the subclones were varying. FACS and cDNA microarray analysis showed that each subclones were composed of distinct population of cells. The sensitivities of some drug were different. In animal models, xenografts from subclones, tumor-progression/invasion and animal survivals were also different. Some clones invaded contra-lateral hemisphere via tract fiber. Our observations suggest that single cell derived subclones from a patient is capable of producing phenotypically heterogeneous self-renewing progenies in an in vitro and in vivo setting. The functional analysis of the heterogeneous GSC clones may provide a better understanding of GSC biology and novel means for testing of new treatment strategies that focus on the eradication of the true GSCs. Citation Format: Akio Soeda, Akira Hara, Takahiro Kunisada, Toru Iwama. The evidence of glioblastoma heterogenity. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2297. doi:10.1158/1538-7445.AM2013-2297
Bullous Myringitis and Atypical Pneumonia
Authors: David O. Merifield
Journal: JAMA (1967)

<h3>To the Editor:—</h3> I read with interest the recent letter of T. J. John, MD, et al (<b>201</b>:273, 1967) concerning the association of bullous myringitis and primary atypical pneumonia. I recently published a study in which we attempted to relate the incidence of bullous myringitis with the Eaton agent,<i>Mycoplasma pneumoniae</i>. In 23 cases of bullous myringitis, complement fixation tests, viral isolation techniques, throat cultures, cold and MG agglutinin tests failed to establish a causal relationship. Complement fixation tests against 21 common viral agents also failed to indicate a relationship. It is my current thought that bullous lesions are probably nonspecific manifestations of mechanical injury which may be associated with upper-respiratory tract infection. I have also been impressed with the frequent occurrence of this disease in children afflicted with allergic diseases.
Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology
Authors: Cristiana Branco da Cunha, Darinka D. Klumpers, Weiwei A. Li, Sandeep T. Koshy, James C. Weaver, Ovijit Chaudhuri, Pedro L. Granja, David J. Mooney
Journal: Biomaterials (2014)
Care of the Critically Ill
Authors: Charles Fisch
Journal: JAMA (1968)

The authors have succeeded in their efforts to present the basic physiological knowledge essential for the intelligent management of the acutely ill. Even the more complex and sophisticated concepts, such as the force-velocity relationship of muscle, are made remarkably clear. Because the book is well illustrated and the text is clearly written it becomes a simple matter for the reader to become familiar with modern-day concepts of cardio-pulmonary physiology. It is difficult in this day and age to care for the acutely ill without having some understanding of the underlying pathophysiology. This book will more than amply serve this purpose, and in addition, it is recommended as a departing point for those who may find this area of pathophysiology interesting and care to pursue it in depth.
Analysis of Circulating Tumor Cells in Patients with Non-small Cell Lung Cancer Using Epithelial Marker-Dependent and -Independent Approaches
Authors: Matthew G. Krebs, Jian-Mei Hou, Robert Sloane, Lee Lancashire, Lynsey Priest, Daisuke Nonaka, Tim H. Ward, Alison Backen, Glen Clack, Andrew Hughes, Malcolm Ranson, Fiona H. Blackhall, Caroline Dive
Journal: Journal of Thoracic Oncology (2011)
884 CXCL1 RS4074 POLYMORPHISM INFLUENCES THE SUSCEPTIBILITY TO HEPATOCELLULAR CARCINOMA
Authors: H.D. Nischalke, M. Coenen, C. Berger, T. Müller, T. Berg, C. Luda, B. Krämer, D. Schulte, C. Körner, J. Nattermann, T. Sauerbruch, U. Spengler
Journal: Journal of Hepatology (2010)
Retroperitoneal fibrosis with a complex cystic lesion mimicking an inferior vena cava tumor
Authors: Surinder Rana, Vishal Sharma, Puneet Chhabra, Ravi Sharma, Rajesh Gupta, Bhagwant Mittal, Deepak Bhasin
Journal: Endoscopy (2015)

A 32-year-old woman presented with a dull aching abdominal pain of 2 months duration. She had similar complaints 18 months earlier and on evaluation, she was found to have a 4-cm cystic lesion near the head of the pancreas ([Fig. 1]). A repeat contrast enhanced computed tomography scan of the abdomen revealed a complex thick-walled cystic lesion measuring ~ 5 cm in size, located near the head of the pancreas and invading the medial wall of the inferior vena cava and involving the left renal vein ([Fig. 2]). Subsequent 18-fluorodeoxyglucose positron emission tomography showed intense uptake in the lesion with a maximum standardized uptake value of 9.0 ([Fig. 3]). Endoscopic ultrasound (EUS) revealed a 5-cm complex septated cystic lesion in relation to the head of the pancreas abutting the inferior vena cava ([Fig. 4]). EUS guided aspiration of the cyst revealed a serosanguinous fluid that was rich in lymphocytes and no malignant cells were seen. The cyst was completely emptied and fluid cancer antigen 19-9, carcinoembryonic antigen, and triglyceride were within normal limits, whereas fluid amylase and lipase were elevated.
Organic emissions from coal pyrolysis: mutagenic effects.
Authors: A G Braun, M J Wornat, A Mitra, A F Sarofim
Journal: Environmental Health Perspectives (1987)

Four different types of coal have been pyrolyzed in a laminar flow, drop tube furnace in order to establish a relationship between polycyclic aromatic compound (PAC) evolution and mutagenicity. Temperatures of 900K to 1700K and particle residence times up to 0.3 sec were chosen to best simulate conditions of rapid rate pyrolysis in pulverized (44-53 microns) coal combustion. The specific mutagenic activity (i.e., the activity per unit sample weight) of extracts from particulates and volatiles captured on XAD-2 resin varied with coal type according to the order: subbituminous greater than high volatile bituminous greater than lignite greater than anthracite. Total mutagenic activity (the activity per gram of coal pyrolyzed), however, varied with coal type according to the order: high volatile bituminous much greater than subbituminous = lignite much greater than anthracite, due primarily to high organic yield during high volatile bituminous coal pyrolysis. Specific mutagenic activity peaked in a temperature range of 1300K to 1500K and generally appeared at higher temperatures and longer residence times than peak PAC production.
Pancreatic Adenocarcinoma: Treating a Systemic Disease With Systemic Therapy
Authors: D. P. Sohal, R. M. Walsh, R. K. Ramanathan, A. A. Khorana
Journal: JNCI Journal of the National Cancer Institute (2014)

Pancreatic adenocarcinoma, even when resectable, remains highly lethal. Although surgical outcomes have improved considerably, median overall survival after surgery and adjuvant therapy such as single-agent gemcitabine remains less than 2 years. We discuss preclinical and clinical data supporting the contention that even early-stage pancreatic cancer is a systemic disease. Autopsy series reveal that 70% to 85% of patients die of systemic recurrence, rather than local disease, after pancreatic cancer resection. Preclinical studies using genomics and mouse models reveal evidence of metastatic spread even before histopathologic evidence of a pancreatic tumor. Analogous to breast cancer, we propose that the Halstedian approach of treating pancreatic cancer as a local, surgical problem should be replaced by Fisher's alternative hypothesis of cancer as a systemic disease. Newer multiagent chemotherapy regimens have shown meaningful response rates and improvement in overall survival in the metastatic setting and, for the first time, offer investigators an opportunity to use effective systemic therapy. We emphasize that a surgery-first approach is not resonant with our current understanding of pancreatic adenocarcinoma biology and that an upfront systemic approach for even resectable pancreatic cancer warrants testing in clinical trials.
Interrelationships between the Human Alveolar Macrophage and Alpha-1-Antitrypsin
Authors: Allen B. Cohen
Journal: Journal of Clinical Investigation (1973)

Alveolar macrophages lavaged from human lungs contain protease activity at an optimum pH of 3.0 and possibly a lesser peak of activity at pH 5.5. Protease activity measured at pH 4.1 is inhibited by purified alpha-1-antitrypsin. Fluorescent antibody studies of human alveolar macrophages showed that alpha-1-antitrypsin is present in normal alveolar macrophages. In addition, macrophages from a patient with a homozygous deficiency of alpha-1-antitrypsin exhibited less fluorescence when incubated in autologous serum than the same macrophages incubated in normal serum. Macrophages from normal subjects showed maximal fluorescence when removed from the lung and additional incubation with serum did not increase fluorescence. These results implicate the human alveolar macrophage as a possible source of an enzyme that may cause emphysema in patients deficient in alpha-1-antitrypsin. They also show that alpha-1-antitrypsin has access to the alveolus in normal subjects.
Allergic contact dermatitis to broccoli
Authors: A. Chakrabarti, L. Prais, I.S. Foulds
Journal: British Journal of Dermatology (2003)

Journal Article Allergic contact dermatitis to broccoli Get access A. Chakrabarti, A. Chakrabarti Birmingham Skin Centre, City Hospital, Dudley Road, Birmingham B18 7QH, U.K. E‐mail: sup30@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar L. Prais, L. Prais Birmingham Skin Centre, City Hospital, Dudley Road, Birmingham B18 7QH, U.K. E‐mail: sup30@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar I.S. Foulds I.S. Foulds Birmingham Skin Centre, City Hospital, Dudley Road, Birmingham B18 7QH, U.K. E‐mail: sup30@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 148, Issue 1, 1 January 2003, Pages 172–173, https://doi.org/10.1046/j.1365-2133.2003.50813.x Published: 01 January 2003
Contraception for the Insulin-dependent Diabetic Woman: The View from One Clinic
Authors: J M Steel, L J P Duncan
Journal: Diabetes Care (1980)

Experience in a large diabetic clinic has confirmed the suspicion that insulin-dependent diabetic women are at considerably increased risk of thromboembolic disease if they take combined estrogen/progestogen oral contraceptive preparations. The most obvious alternative, an intrauterine device, is associated with an unexpectedly high failure rate, probably because of an unusual metabolic interaction with the diabetic endometrium. In a small group of diabetic women the progestogen-only pill was found to be a successful form of contraception not associated with any side effects except for menstrual irregularities. For most diabetic women the choice of contraceptive should therefore be between a progestogen-only pill and a mechanical method. Female sterilization and injectable progesterone each have their place in particular circumstances. Careful counseling of each patient is essential to ensure the best choice of contraceptive and correct application of the chosen method.
European Scleroderma Study Group to define disease activity criteria for systemic sclerosis. IV. Assessment of skin thickening by modified Rodnan skin score
Authors: G Valentini
Journal: Annals of the Rheumatic Diseases (2003)

The European Scleroderma Study Group (EScSG) has recently identified three activity 10 point indices devoted to evaluating disease activity in systemic sclerosis (SSc) (table 1),1 which have been externally validated.2

An activity index must rely on widely used methods.3 The whole series index includes the total skin score (TSS) evaluated according to the scoring method of Kahaleh et al (KTSS).4 Because, at present, the modified Rodnan TSS (mRTSS)5 is the method most widely used to assess skin induration in SSc, we considered that the …
Use of automated repetitive-sequence-based PCR for rapid laboratory confirmation of nosocomial outbreaks
Authors: A.J. Grisold, G. Zarfel, V. Strenger, G. Feierl, E. Leitner, L. Masoud, M. Hoenigl, R.B. Raggam, V. Dosch, E. Marth
Journal: Journal of Infection (2009)
Studying reproductive risks, smoking
Authors: Helene Cole
Journal: JAMA (1986)

No longer can those persons who smoke cigarettes naively assume that their habit harms only themselves, and women and their unborn infants are at special risk. New warnings from the surgeon general of the Public Health Service, displayed on cigarette packages and in advertisements, attest that in addition to causing lung cancer, heart disease, and emphysema, smoking can complicate pregnancy, resulting in premature birth, low birth weight, and fetal injury. These risks and others, including a greater risk of infertility, spontaneous abortion, ectopic pregnancy, and earlier menopause, were recently highlighted at the first International Conference on Smoking and Reproductive Health. The conference, sponsored by Family Health International, Research Triangle Park, NC; the Centers for Disease Control, Atlanta; Office on Smoking and Health, Agency for International Development, and Health Resources and Services Administration, Washington, DC; National Institute of Child Health and Human Development, Bethesda, Md; University of California, San Francisco; and
Normal Thyroxine Levels in Sudden Infant Death Syndrome
Authors: Max Bader
Journal: JAMA (1982)

<h3>To the Editor.—</h3> In the QUESTIONS AND ANSWERS section (1982;248:593), the association between sudden infant death syndrome (SIDS) and elevated triiodothyronine (T<sub>3</sub>) levels found at autopsy was discussed. The answer indicated that there was no proved causative association between elevated T<sub>3</sub>levels and the later development of SIDS. It might be worth noting that all of 30 consecutive Oregon SIDS infants had essentially normal thyroxine levels at the time of newborn screening for congenital hypothyroidism. In addition, none of 66 infants found to have congenital hypothyroidism at the time of newborn screening subsequently died of SIDS.
TCTAP A-009 Clinical Outcome of Preventive Angioplasty in ST-Elevation Myocardial Infarction
Authors: Jae Hyung Roh, Hyun Woo Park, Se Hun Kang, Min Su Kim, Hee-soon Park, Byeong Joo Bae, Sang Soo Cheon, Pil Hyung Lee, Mineok Chang, Sung Han Yoon, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2015)
Major African clinical trial ends early due to high mortality in children
Authors: N. Siva
Journal: BMJ (2011)

A large African trial testing the routine use of rapid fluid bolus resuscitation in children with shock has been stopped early because of the number of deaths in children during the two year study.

Doctors have reacted with surprise at the high mortality seen during the FEAST study (Fluid Expansion as Supportive Therapy) in which 3170 children in shock caused by severe infection were assessed in hospitals in Uganda, Kenya, and Tanzania over two years.

Over the past 20 years the technique of fluid bolus resuscitation has been standard practice in children with shock due to severe infections, such as septicaemia or malaria. …
Lectures on the Whole of Anatomy: William Harvey; An Annotated Translation of Prelectiones Anatomiae Universalis
Authors: A. C. Corcoran
Journal: JAMA (1962)

In 1616 and for some 10 years after, Harvey gave the Lumleian lectures on anatomy at the Royal College of Physicians. His lecture notes, in synoptic, rough Latin, with occasional lapses into English ( italicized here) were preserved by the College. These notes convey a great deal of insight. Harvey was not only a superb physiologist, he was also skilled and learned in both human and comparative anatomy. He had a gift for illustrative, particularly clinical, allusions, most of them to his own practice, which seems to have been larger than Aubrey indicated. Statements verified by personal observation are initialled WH. Notes for a lecture probably delivered in January, 1618, include, without comment, the statement: "( WH) From the structure of the heart it is clear that blood is constantly carried through the lungs into the aorta as<i>by two clacks of a water bellows to rayse water</i>.... the beat of the