Renal Pressor Material in Various Hypertensive Diseases
Authors: Warren E. Goorno, Norman M. Kaplan
Journal: Annals of Internal Medicine (1965)

Article1 November 1965Renal Pressor Material in Various Hypertensive DiseasesWARREN E. GOORNO, M.D., NORMAN M. KAPLAN, M.D., F.A.C.P.WARREN E. GOORNO, M.D., NORMAN M. KAPLAN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-745 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe kidney may cause hypertension by the elaboration of a pressor material in the presence of renal ischemia. The prevailing theory is that a decrease in the pressure within the renal afferent arteriole (1, 2) causes the juxtaglomerular apparatus to release the enzyme renin (3), which in turn acts enzymatically upon a substrate in the circulation to produce the decapeptide angiotensin I. Angiotensin I is then acted upon by a converting enzyme to produce the potent pressor octapeptide, angiotensin II (4).We have attempted to assess the role of the renal pressor mechanism in various hypertensive states. Two different methods...References1. KOHLSTAEDTPAGE KGIH: The liberation of renin by perfusion of kidneys following reduction of pulse pressure. J. Exp. Med. 72: 201, 1940. CrossrefMedlineGoogle Scholar2. HAWTHORNEPERRYPOGUE EWSLWG: Development of experimental renal hypertension in the dog following reduction of renal artery pulse pressure without reducing mean pressure. Amer. J. Physiol. 174: 393, 1953. CrossrefMedlineGoogle Scholar3. TOBIAN L: Relationship of juxtaglomerular apparatus to renin and angiotensin. Circulation 25: 189, 1962. CrossrefMedlineGoogle Scholar4. PAGEBUMPUS IHMF: Angiotensin. Physiol. Rev. 41: 331, 1961. CrossrefMedlineGoogle Scholar5. KAPLANSILAH NMJG: The angiotensin infusion test: a new approach to the differential diagnosis of renovascular hypertension. New Eng. J. Med. 271: 536, 1964. CrossrefMedlineGoogle Scholar6. GROLLMAN A: Antihypertensive and pressor agents of renal origin. Canad. Med. Ass. J. 90: 299, 1964. MedlineGoogle Scholar7. KAPLANSILAH NMJG: The effect of angiotensin II on the blood pressure in humans with hypertensive disease. J. Clin. Invest. 43: 659, 1964. CrossrefMedlineGoogle Scholar8. MCPHAULMCINTOSHWILLIAMSGRITTIMALETTEGROLLMAN JJDALFEJWGA: Pressor activity of renal venous blood in hypertension. Ann. Intern. Med. 61: 847, 1964. LinkGoogle Scholar9. BROWNDAVIESLEVERROBERTSON JJDLAFJI: Variations in plasma renin concentration in several physiological and pathological states. Canad. Med. Ass. J. 90: 201, 1964. MedlineGoogle Scholar10. CONNCOHENROVNER JWELDR: Suppression of plasma renin activity in primary aldosteronism. JAMA 190: 213, 1964. CrossrefMedlineGoogle Scholar11. KAPLANSILAH NMJC: Angiotensin infusion: a new test for renovascular hypertension (abstract). Clin. Res. 12: 254, 1964. Google Scholar12. HELMER OM: Renin activity in blood from patients with hypertension. Canad. Med. Ass. J. 90: 221, 1964. MedlineGoogle Scholar13. PEART WS: Hypertension and the kidney. Brit. Med. J. 2: 1421, 1959. CrossrefMedlineGoogle Scholar14. MCPHAULMCINTOSHWILLIAMSGRITTIMALETTEGROLLMAN JJDALFEJWGA: Remediable hypertension due to unilateral renal disease. Arch. Intern. Med. (Chicago) 115: 644, 1965. CrossrefMedlineGoogle Scholar15. GROLLMAN A: Personal communication. Google Scholar16. GUNNELLS JC: Circulating vasoconstrictors material in hypertension (abstract). Circulation 30(III): 90, 1964. MedlineGoogle Scholar17. LAWRENCEDOIGKNIGHTMACLARENDONALD JRAICIFKW: Renal artery stenosis without renal ischemia. Lancet 1: 62, 1964. CrossrefMedlineGoogle Scholar18. DUSTANHUMPHRIESDE WOLFEPAGE HPAWVGIH: Normal arterial pressure in patients with renal arterial stenosis. JAMA 187: 1028, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dallas, TexasFrom the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Tex.This study was supported in part by grants AM-06938 and HE-07916-03, U. S. Public Health Service, Washington, D. C.Dr. Goorno is a Research Fellow, University of Texas Southwestern Medical School, Dallas, Tex.Requests for reprints should be addressed to Norman M. Kaplan, M.D., Department of Internal Medicine, Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, Tex. 75235. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAcute Glomerulonephritis and Glomerulonephritis in Bacterial EndocarditisThe Acute Glomerulonephritis SyndromePoststreptococcal Acute Glomerulonephritis: Fact and ControversyALLEN R. NISSENSON, M.D., LARRY J. BARAFF, M.D., RICHARD N. FINE, M.D., DAVID W. KNUTSON, M.D.Absence of Hyperactive Renal Humoral Pressor System in Spontaneously Hyptertensive RatsPeripheral and Renal Venous Plasma Renin Activity in HypertensionJ. CAULIE GUNNELLS JR., M.D., F.A.C.P., W. L. MGGUFFIN JR., B.S., IRWIN JOHNSRUDE, M.D., R. R. ROBINSON, M.D., F.A.C.P.Ergebnisse des Angiotensin-Infusionstests beim renovasculären Hochdruck und anderen HypertonieformenZur Pathogenese der sogenannten malignen HypertoniePlasma renin activity in renovascular hypertensionRenal arterial hypertensionPressor response to angiotensin II in hypertensionPhysiologie und Pathologie des Renin/Angiotensin-SystemsRenal Venous Renin Determinations in the Diagnosis of Surgically Correctable HypertensionVascular reactivity in essential and renal hypertension in manRenin, Angiotensin and Aldosterone in Renovascular Disorders 1 November 1965Volume 63, Issue 5Page: 745-751KeywordsArteriolesEnzymesGlomerulonephritisHypertensionKidneysLesionsMedical servicesRenal diseasesRenal ischemiaResearch laboratories Issue Published: 1 November 1965 CopyrightCopyright ©, 1965, by The American College of PhysiciansPDF DownloadLoading ...