tbuckley/cabot-search huggingface dataset:
Abstract 1251: Increased expression of the plasminogen activator system due to differential protease-activated receptor signaling in breast cancer cells
Authors: Troy McEachron, Frank Church, Nigel Mackman
Journal: Cancer Research (2010)

Abstract Activation of protease activated receptor-1 and −2 (PAR-1 and PAR-2) on tumor cells by coagulation proteases, such as factor Xa (FXa) and thrombin, leads to the expression of urokinase plasminogen activator (uPA) and its inhibitor plasminogen activator inhibitor type-1 (PAI-1). uPA has been shown to contribute to malignancy by increasing tumor cell migration, survival, extracellular matrix degradation, and angiogenesis. The goal of this study was to determine how activation of PAR-1 and PAR-2 by coagulation proteases regulates uPA and PAI-1 expression. We used the 4T1 mouse mammary adenocarcinoma cell line as a model because it expresses both PAR-1 and PAR-2. Using shRNA technology, we made derivatives of the 4T1 cells with reduced expression of either PAR-1 or PAR-2. 4T1 cells carrying a non-targeting shRNA construct were used as negative controls. We found that FXa and thrombin induced uPA expression in the control and the PAR-2 shRNA cells, but not in the PAR-1 shRNA cells. In contrast, FXa treatment did not increase PAI-1 levels in the control, PAR-1 shRNA, or PAR-2 shRNA cells. Thrombin was able to induce PAI-1 in the control cells, but not in the PAR-1 shRNA or the PAR-2 shRNA cells. Taken together, our data suggests that uPA expression is dependent on PAR-1 activation whereas PAI-1 expression requires a PAR-1/PAR-2 heterodimer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1251.
All My Husband Needed Was a Good Physical Examination
Authors: Sandra Zimmerman
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Association Between Nutritional Status and Cognitive Functioning in a Healthy Elderly Population
Authors: James S. Goodwin
Journal: JAMA (1983)

We evaluated the association between nutritional status and cognitive functioning in 260 noninstitutionalized men and women older than 60 years who had no known physical illnesses and were receiving no medications. Nutritional status was evaluated by three-day food records and also by biochemical determination of blood levels of specific nutrients. Cognitive status was evaluated by the Halstead-Reitan Categories Test (a nonverbal test of abstract thinking ability) and by the Wechsler Memory Test. Subjects with low blood levels of vitamins C or B<sub>12</sub>scored worse on both tests. Subjects with low levels of riboflavin or folic acid scored worse on the categories test. These differences remained significant after controlling for age, gender, level of income, and amount of education. "Subclinical" malnutrition may play a small role in the depression of cognitive function detectable in some elderly individuals, or depressed cognitive function may result in reduced nutrient intake. (<i>JAMA</i>1983;249:2917-2921)
STUDIES ON THE RESPIRATORY MECHANISM IN LOBAR PNEUMONIA
Authors: Carl A. L. Binger, George R. Brow
Journal: The Journal of Experimental Medicine (1924)

1. The functional residual air (defined as the lung volume at the end of normal expiration) has been determined in a series of normal individuals and in ten patients with lobar pneumonia at different stages of the disease. 2. The rate, depth, and minute volume of respirations were measured in the same individuals by a graphic method. 3. When appreciable cyanosis was present the oxygen content and capacity of the arterial blood were determined. 4. A constant relationship has been found to exist between the persistence and disappearance of symptoms (fever, accelerated heart rate, rapid and shallow breathing, cyanosis) and fluctuations of the functional residual air. When these symptoms persisted the functional residual air decreased; during their disappearance the volume of the functional residual air rose towards normal. The rise was detected soon after the crisis. 5. A close parallelism has been observed also between alterations in radiographic shadow, physical signs, and the volume of the functional residual air. The lung volume, measured at normal expiration, is diminished during the persistence of pathological signs in the lungs, and returns to normal as the pathological signs disappear. The average time required, in cases which recovered, for the functional residual air to become constant was 11 to 12 days, counting from the onset of the disease.
Points: Pets to stabilise schizophrenics
Authors: M. Lloyd-Evans
Journal: BMJ (1980)

Hyperlipidaemia advances and retreatsDr A LEWIS (London WlN 1FJ) writes: How long will it be before the hazards of eating dairy foods (23 August, p 564) are remembered with amusement like those of eating meat.This dangerous stuff (especially red meat) "caused" kidney disease, hypertension, rheumatism, and gout because it was a source of uric acid and urea, with which these conditions were thought to be associated. Drugs and rheumatoid arthritisDr JACK BOURNE (Hornchurch, Essex) writes: In his letter on the effect of corticosteroids on the manifestations of rheumatoid arthritis,
Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice
Authors: Kati J. Ahlqvist, Riikka H. Hämäläinen, Shuichi Yatsuga, Marko Uutela, Mügen Terzioglu, Alexandra Götz, Saara Forsström, Petri Salven, Alexandre Angers-Loustau, Outi H. Kopra, Henna Tyynismaa, Nils-Göran Larsson, Kirmo Wartiovaara, Tomas Prolla, Aleksandra Trifunovic, Anu Suomalainen
Journal: Cell Metabolism (2012)
An unusual cause of obscure gastrointestinal bleeding in a patient with cirrhosis
Authors: Chi-Ming Tai, Hao-Ming Li, Chao-Ming Hung, Kai-Jen Lin, Jaw-Town Lin
Journal: Gut (2012)

A 59-year-old woman with hepatitis C virus-related cirrhosis and oesophageal varices underwent laparotomy and right salpingo-oophorectomy for right ovarian fibroma, 6 months prior to this admission. The pre-operative CT scan, for the assessment of the ovarian fibroma revealed, incidentally, subcutaneous umbilical collateral vessels (figure 1A). A ventral hernia developed 3 months after the surgery, and the size of the hernia sac enlarged progressively. The patient was admitted because she passed bloody stools the day before admission. On admission, the physical examination revealed collateral veins and a soft bulging mass in the lower abdomen. The laboratory examination revealed: haemoglobin, 7.1 gm/dl …
Should our children be sitting comfortably in school?
Authors: A. C. Routen
Journal: BMJ (2011)

Aware of the irony of writing about sedentary behaviour while sitting for prolonged periods most days, I type this viewpoint while pedalling on a micro-exercise bike that fits underneath my desk. 

In early February of this year the Canadian Society for Exercise Physiology (CSEP) released guidelines on sedentary behaviour among children and young people aged 5 to 17. These are the first evidence based guidelines published on this topic, and they mark an important shift in the appreciation of sedentary behaviour as an independent health risk. Over the past decade researchers have begun to redefine our understanding of what constitutes sedentary behaviour, shifting the focus from simply the absence of sufficient health enhancing physical activity. Some research groups now posit that sedentarism is the engagement in a separate class of behaviours characterised by minimal movement and low energy expenditure—for example, sitting or watching television.

Research is now showing that prolonged sedentary behaviour is independently and positively associated with …
Come back DDT--all is forgiven
Authors: J. Currey
Journal: BMJ (1994)

About a year ago my elderly dachshund started to cry and pace about the house in the evenings. At first I thought that he was asking for extra food. I then wondered if he could be ill or in pain, but the vet said that he seemed fine. We tried an extra evening biscuit and he had the usual veterinary panacea of a course of steroids, but he was no better.

The awful truth eventually dawned: his problem was due to fleas. My mind went back to a horrendous evening when I found him in the garden nosing a hedgehog and with …
Home Treatment of Chronic Morphinism.
Authors: A. J. Pressey
Journal: JAMA (1899)

Cleveland, Ohio, Dec. 26, 1898. <h3>To the Editor:</h3> —I notice an article on page 1423 of theJournal(Dec. 10, 1868) on the above title. I am somewhat at a loss to understand whether the item was published for the sake of condemning the method or not. I think that it must have that effect on the profession and am sure that it will have on the habitue. Any method of treatment that is of itself cruel enough to torture patients to the extent of driving nearly per cent, of them to suicide within three days of the time of commencing it, should be classed with the cruelties of Nero rather than as belonging to modern medicine. I have treated thirty cases of chronic morphinism in the past year, some of them taking as much as 40 grains per day hypodermically (I never refuse a patient because of the amount
My lonely battle with disease
Authors: J. O. Drife
Journal: BMJ (1997)

Now that this column appears with personal views I feel empowered to reveal my own medical problem. It was not an easy decision. I thought hard about the effect that this might have on those close to me. Admitting to sickness invites prejudice, even among doctors.

It all began two years ago. I was sitting at my desk and staring out of the window, an important activity for us academics. During it I sometimes touch my ear lobe but one day, for no particular reason, I touched both simultaneously. With a shock I realised that the left was bigger than the …
Low High-Density Lipoprotein Cholesterol Is Not a Risk Factor for Recurrent Vascular Events in Patients With Vascular Disease on Intensive Lipid-Lowering Medication
Authors: Anton P. van de Woestijne, Yolanda van der Graaf, An-Ho Liem, Maarten J.M. Cramer, Jan Westerink, Frank L.J. Visseren
Journal: Journal of the American College of Cardiology (2013)
A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium report†
Authors: Jack M. Su, Patrick Thompson, Adekunle Adesina, Xiao-Nan Li, Lindsay Kilburn, Arzu Onar-Thomas, Mehmet Kocak, Brenda Chyla, Evelyn McKeegan, Katherine E. Warren, Stewart Goldman, Ian F. Pollack, Maryam Fouladi, Alice Chen, Vincent Giranda, James Boyett, Larry Kun, Susan M. Blaney
Journal: Neuro-Oncology (2014)

A phase I trial of veliparib (ABT-888), an oral poly(ADP-ribose) polymerase (PARP) inhibitor, and temozolomide (TMZ) was conducted in children with recurrent brain tumors to (i) estimate the maximum tolerated doses (MTDs) or recommended phase II doses (RP2Ds) of veliparib and TMZ; (ii) describe the toxicities of this regimen; and (iii) evaluate the plasma pharmacokinetic parameters and extent of PARP inhibition in peripheral blood mononuclear cells (PBMCs) following veliparib. TMZ was given once daily and veliparib twice daily for 5 days every 28 days. Veliparib concentrations and poly(ADP-ribose) (PAR) levels in PBMCs were measured on days 1 and 4. Analysis of pharmacokinetic and PBMC PAR levels were performed twice during study conduct to rationally guide dose modifications and to determine biologically optimal MTD/RP2D. Twenty-nine evaluable patients were enrolled. Myelosuppression (grade 4 neutropenia and thrombocytopenia) were dose limiting. The RP2Ds are veliparib 25 mg/m2 b.i.d. and TMZ 135 mg/m2/d. Only 2 out of 12 patients treated at RP2Ds experienced dose-limiting toxicities. Although no objective response was observed, 4 patients had stable disease >6 months in duration, including 1 with glioblastoma multiforme and 1 with ependymoma. At the RP2D of veliparib, pediatric pharmacokinetic parameters were similar to those in adults. Veliparib and TMZ at the RP2D were well tolerated in children with recurrent brain tumors. A phase I/II trial to evaluate the tolerability and efficacy of veliparib, TMZ, and radiation in children with newly diagnosed brainstem gliomas is in progress.
Tc-99m PMT Whole-Body Scintigraphy for Evaluation of Therapeutic Effect and for Monitoring Bone Metastasis in a Patient with Hepatocellular Carcinoma
Authors: KOZO SUEYOSHI, ISAMU NARABAYASHI, KENJI DOI, MASATUGU TAKAHASHI, TUYOSHI KOMORI, YOSHIMITU TATSU, TOMOAKI TATSUMI, KEITA UTUNOMIYA, YASUO UESUGI, ITARU ADACHI, TADAFUMI SHIMIZU
Journal: Clinical Nuclear Medicine (2000)

Detection of metastatic lesions by bone scintigraphy is highly sensitive but has a low rate of specificity. Often bone metastases from hepatocellular carcinoma are not detected by bone scintigraphy because of low uptake or a photopenic area in the tumor. In contrast, Tc-99m Sn-N-pyridoxy-5-methyltryptophan (Tc-99m PMT) whole-body scintigraphy reflects tumor viability, and the specificity of detection is so high that tumor structure can be shown well. Tc-99m PMT whole-body scintigraphy was helpful for evaluating the response to therapy and monitoring the course of the patient described here with bone metastasis from hepatocellular carcinoma.
Attenuated Psychosis Syndrome: Ready for DSM-5.1?
Authors: P. Fusar-Poli, W.T. Carpenter, S.W. Woods, T.H. McGlashan
Journal: Annual Review of Clinical Psychology (2014)

Prodromal features of the schizophrenia syndrome have been described for a century, and work in the past two decades has produced a substantial literature based on these features to identify individuals at increased risk for developing a psychotic disorder. Sometimes conceptualized as a "risk state" and sometimes as early manifestations of a "disorder," the work has been conducted with several related but different constructs. Early in the preparation of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) public comment was sought on the proposal to create a new disorder termed attenuated psychosis syndrome (APS), and a range of issues emerged that generated interesting and important controversies. In this review, these criticisms are fully discussed, the APS concept is explicated; data relating to reliability, validity, and treatment are updated; the heterogeneity of APS is considered; and alternative views of the construct are presented with an emphasis on developmental pattern with timing for primary and secondary prevention and early treatment. Areas of future research are identified, and a potential roadmap for inclusion in DSM-5.1 is traced.
Abstract P348: The Effects of High Saturated Fat Intake on LDL and HDL Subclasses in Individuals with Atherogenic Dyslipidemia
Authors: Sally Chiu, Ronald M Krauss
Journal: Circulation (2012)

Previous observations in normolipidemic individuals have indicated that the increase in LDL cholesterol (C) resulting from substitution of dietary saturated fat for carbohydrate or unsaturated fat is primarily due to higher plasma levels of large cholesterol-enriched LDL particles, with minimal effects on smaller LDL, as well as apolipoprotein (apo) B and total-C/HDL-C ratio. In the present study, we tested whether similar effects of saturated fat are observed in individuals with atherogenic dyslipidemia characterized by a preponderance of small LDL particles (LDL phenotype B). Fifty-three phenotype B participants consumed a baseline diet (55% carbohydrate, 15% protein, 30% fat, 8% saturated fat) for 3 weeks, after which they were randomized to either a moderate carbohydrate, high saturated fat diet (HSF; 39% carbohydrate, 25% protein, 36% fat, 18% saturated fat) or a moderate carbohydrate, low saturated fat diet (LSF; 37% carbohydrate, 25% protein, 37% fat, 9% saturated fat) for 3 weeks. The difference in saturated fat was derived primarily from dairy sources. Plasma lipids and lipoproteins were measured after the baseline and randomized diets. Compared to the LSF diet, participants who consumed the HSF diet had a greater percent increase in total-C (p&lt;0.0001), LDL-C (p=0.0002), total-C/HDL-C ratio (p=0.0004) and apoB (p&lt;0.0001) from the baseline diet, with no significant differences in HDL-C or apoAI. The HSF group had a greater percent increase in medium (p=0.05) and small (p=0.02) LDL particle concentrations from baseline compared to the LSF group, with no differences in large and very small LDL. There were also no significant differences in large and small HDL subclasses. The activities of both hepatic lipase (p=0.05) and cholesteryl ester transfer protein (p=0.04) were increased in the HSF group compared to the LSF group. Because medium and small LDL particles have been found to be more highly associated with CVD risk than larger LDL particles, the present results, in conjunction with our previous findings, suggest that adverse effects of very high saturated fat intake on CVD risk may be greater in phenotype B individuals than in those with normal lipoprotein profiles.
Ischaemia and the myocyte cytoskeleton: review and speculation
Authors: C. Ganote, S. Armstrong
Journal: Cardiovascular Research (1993)

Journal Article Ischaemia and the myocyte cytoskeleton: review and speculation Get access Charles Ganote, Charles Ganote Department of Pathology, James H Quillen School of Medicine, East Tennessee State University, Johnson City, TN 37614, USA: C Ganote, S Armstrong. Correspondence to Dr Ganote. Search for other works by this author on: Oxford Academic PubMed Google Scholar Stephen Armstrong Stephen Armstrong Department of Pathology, James H Quillen School of Medicine, East Tennessee State University, Johnson City, TN 37614, USA: C Ganote, S Armstrong. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 8, August 1993, Pages 1387–1403, https://doi.org/10.1093/cvr/27.8.1387 Published: 01 August 1993 Article history Received: 01 July 1992 Accepted: 26 November 1992 Published: 01 August 1993
1026-57 Coronary atherosclerosis is more advanced in the patients with acute myocardial infarction than unstable angina
Authors: Yasunori Ueda, Isamu Mizote, Tomohito Ohtani, Yuji Okuyama, Masaya Usami, Atsushi Hirayama, Kazuhisa Kodama
Journal: Journal of the American College of Cardiology (2004)
Near Death in Twins, Reported 22 Years Ago
Authors: Millard Bass
Journal: JAMA (1992)

<h3>To the Editor.</h3> —We recently investigated the near-death events in 2-month-old fraternal twin boys that occurred on the same day in each twin 22 years ago in Kansas. This curious case of near death in twin infants born prematurely was reported by Leland Speer, MD, in<i>JAMA</i>in 1973 as possible aborted sudden infant death syndrome (SIDS).<sup>1</sup>Correspondence and a meeting in Kansas with Dr Speer a few years ago furthered our interest in the phenomenon of aborted near-miss SIDS in the twin boys. However, the prospect of explaining the cause of the near-miss SIDS events seemed remote. Now adults, the twins are physically mature and active but mentally retarded. They live with their parents in the same home as in 1970, and the house has not undergone any major repairs or alterations. Two physicians who treated the twins in the hospital emergency department on the day that prolonged
A Unique Finding on 1-123 MIBG Imaging Pericardial Effusion
Authors: NANCY J. FISCHBEIN, MICHAEL W. DAE, E DAYAN SANDLER
Journal: Clinical Nuclear Medicine (1992)

A 4-year-old girl was diagnosed with stage 111 neuroblastoma in October 1990. Conventional therapy failed to cure her, and she was treated with high-dose chemotherapy followed by autologous bone marrow transplantation. In August 1991, she underwent routine clinical restaging that included 1–123 MlBG imaging 24 hours after injection. The scan showed normal biodistribution of the radiopharmaceutical without focal activity to suggest recurrent disease. However, imaging of the anterior part of the thorax (Fig. 1) revealed a photopenic area surrounding the heart consistent with a pericardial effusion, which was also seen on the chest CT. This finding may not have been previously described on MlBG imaging.
TUBERCULIN IN OBSCURE MANIFESTATIONS OF TUBERCULOSIS.
Authors: W. H. WEAVER
Journal: JAMA (1897)

If the earliest symptoms and signs of consumption were as easily definable and as pathognomonic of the disease as those manifested in the later stages, it might be easily diagnosed in its incipiency. But, unfortunately, this has not been the fact. In a great many cases the onset is sudden or occurs during the progress of a severe cold or bronchial catarrh, or following in the wake of some other acute disease. Frequently, however, it is ushered in by symptoms which point to no particular form of disease, and it is this class of cases that is the most puzzling until we find pronounced symptoms pointing to lung infection. There are often certain symptoms of a general constitutional impairment, insufficient in themselves to render a diagnosis possible, but which do point to a definite disease if properly studied. There are many cases occurring in active practice in which a positive