tbuckley/cabot-search huggingface dataset:
Plasma Cortisol and Primary Aldosteronism
Authors: CLAUDE K. LARDINOIS
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 June 1984Plasma Cortisol and Primary AldosteronismCLAUDE K. LARDINOIS, M.D., ERNEST L. MAZZAFERRI, M.D., D. BYRON MCGREGOR, M.D.CLAUDE K. LARDINOIS, M.D.Search for more papers by this author, ERNEST L. MAZZAFERRI, M.D.Search for more papers by this author, D. BYRON MCGREGOR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-6-917 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Aldosterone-producing adenoma and hyperplasia are found in most patients with primary aldosteronism. The distinction between the two is important because surgery is likely to cure the hypertension with an aldosterone-producing adenoma but is seldom helpful in hyperplasia. An early morning postural fall in plasma aldosterone—actually the result of diurnal adrenocorticotrophin variation—suggests an aldosterone-producing adenoma, whereas the opposite usually occurs with hyperplasia. We report the case of a patient who was incorrectly thought to have hyperplasia because of a postural rise in plasma aldosterone.A 54-year-old man presented with blood pressure of 200/120 mm Hg and a serum...References1. FRASERBERETTA-PICCOLIBROWN RCJ. Response of aldosterone and 18-hydroxycorticosterone to angiotension II in normal subjects and patients with essential hypertension, Conn's syndrome, and non-tumorous hyperaldosteronism. Hypertension. 1981;3(suppl 1):I87-92. MedlineGoogle Scholar2. GANGULYMELADALUETSHER AGJ. Control of plasma aldosterone in primary aldosteronism: distinction between adenoma and hyperplasia. J Clin Endocrinol Metab. 1973;37:765-75. CrossrefMedlineGoogle Scholar3. VETTERSIEBENSCHEINSTUDER HRA. Primary aldosteronism: inability to differentiate unilateral from bilateral adrenal lesions by various routine clinical and laboratory data and by peripheral plasma aldosterone. Acta Endocrinol (Copenh). 1978;89:710-25. CrossrefMedlineGoogle Scholar4. BRAVOTARAZIDUSTAN ERH. The changing clinical spectrum of primary aldosteronism. Am J Med. 1983;74:641-51. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Nevada School of Medicine Reno, NV 89557 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPrimary Aldosteronism 1 June 1984Volume 100, Issue 6Page: 917-918KeywordsAdenomasAldosteroneBlood plasmaBlood pressureCortisolFallsHypertensionSurgery Issue Published: 1 June 1984 PDF DownloadLoading ...
Plasma Insulin and Glucose Profiles in Normal, Obese, and Diabetic Persons
Authors: SAUL M. GENUTH
Journal: Annals of Internal Medicine (1973)

Plasma insulin and glucose levels were measured hourly, from 8 AM to midnight in normal, obese, juvenile diabetic, and adult diabetic persons with and without obesity. Normal persons showed narrow glucose excursions and sharp postprandial insulin spikes. Obese persons showed three fold increases in fasting and postprandial insulin levels. In obese persons with mild carbohydrate intolerance, postprandial insulin release was delayed. Juvenile diabetics manifested complete insulin lack. Severely diabetic adults still showed definite although reduced postprandial insulin spurts, and the entire plasma insulin profile was still elevated by obesity. From plasma insulin areas and previously established values for metabolic insulin clearance, daily peripheral insulin deliveries were calculated: normal, 31 units; obese persons, 114 units; juvenile diabetics, 4 units; adult diabetics, 14 units; adult, obese diabetics, 46 units. Sixty percent of insulin delivery occurred postprandially in normal and nondiabetic obese persons, but, for frankly diabetic subjects, only 25% was delivered postprandially.
C7-07: Presence of amphiregulin autocrine-loop predicts in vitro sensitivity of EGFR wild type NSCLC and HNSCC cell lines to gefitinib and cetuximab
Authors: Kimio Yonesaka, Kreshnik Zejnullahu, Alison J. Homes, Bruce E. Johnson, Pasi A. Janne
Journal: Journal of Thoracic Oncology (2007)
Role of Renin in Acute Postural Homeostasis
Authors: SUZANNE OPARIL, CARLOS VASSAUX, CHARLES A. SANDERS, EDGAR HABER
Journal: Circulation (1970)

Plasma renin activity has been measured by radioimmunoassay at frequent intervals after passive upright tilting and correlated with pulse and blood pressure in normotensive man. In the normal response to upright posture, renin activity in both peripheral and renal veins increases consistently within a few minutes. The renin rise lags behind the increase in pulse rate and diastolic blood pressure. Renin activity falls to base-line level soon after return to the horizontal position. In the 25% of normal subjects who develop vasovagal syncope after upright tilting, the increase in renin activity is smaller in magnitude and duration than in the normal response. Renin levels fall just before syncope appears and rise sharply after return to the horizontal position. Anephric patients are able to effect adequate postural adjustments even in the absence of renin activity. This study indicates that the renin angiotensin system participates in the acute response to postural change in normal man and that it functions abnormally in vasovagal syncope.
Physician Quality and Maintenance of Certification
Authors: Marc Stephen Frager, Hal Scherz, Alieta Eck
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
783 ASSOCIATION OF PRETREATMENT AND ON-TREATMENT FACTORS WITH NULL RESPONSE IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN
Authors: A.M. DiBisceglie, T.I. Hassanein, L.J. Jeffers, F.M. Hamzeh, K.L. Lindsay, R.T. Chung
Journal: Journal of Hepatology (2008)
Intermittent Acute Porphyria Treated with Chlorpromazine
Authors: Robert N. Monaco, Robert D. Leeper, Jacob J. Robbins, George L. Calvy
Journal: New England Journal of Medicine (1957)

INTERMITTENT acute porphyria reflects a fundamental disturbance of porphyrin metabolism at the cellular level, and its recognition is a challenging clinical event.In the past, treatment of this curious condition has been singularly ineffective and most frustrating. Thus, one recalls early but inconstant success with a variety of agents, including liver extract, vitamins, antihistamines, ganglionic-blocking agents, ACTH, corticosteroids and innumerable others aimed at control of one or more distressing symptoms.The purpose of this communication is to call attention to the striking amelioration of pain and nervousness that has been observed during chlorpromazine therapy of 4 porphyric patients during the . . .
Asthma and Allergy in Finnish Conscripts
Authors: Tari Haahtela, Hannu Jokela
Journal: Allergy (1979)

We studied the occurrence of asthma, bronchial wheezing, allergic rhinitis and atopic dermatitis in 295 young men aged 18-19 years. The relationship of these symptoms to the immediate skin test reactivity was also determined. Symptoms indicating past or current allergy and bronchial wheezing were observed in 36%. The cumulative prevalence of asthma was 2.7%, bronchial wheezing 9% in addition, allergic rhinitis (including allergic conjunctivitis) 20%, and atopic dermatitis (including allergic urticaria) 20%. Positive immediate skin prick test reactions were observed in 50% of the population. Allergic rhinitis was most clearly connected with a positive skin test. This study shows that the respiratory disorders, generally considered to be allergic in origin, and atopic dermatitis are more common in Finland than has been assumed. The results are, however, in accordance with the observations made in other industrialized countries. Susceptibility to asthmatic reactions and allergic symptoms should be taken into account, more so than at present, when mudging the capability of a young man to manage compulsory military service.
New P2Y <sub>12</sub> Inhibitors
Authors: Marco Cattaneo
Journal: Circulation (2010)

A denosine diphosphate (ADP) plays a key role in the genesis of physiological platelet-rich hemostatic plugs and of pathological arterial thrombi. 1 The transduction of the ADP signal involves its interaction with 2 platelet receptors, the G q -coupled P2Y 1 receptor and the G i -coupled P2Y 12 receptor, which belong to the family of purinergic P2 receptors.Concomitant activation of both the G q and G i pathways by ADP is necessary to elicit normal platelet aggregation. 2In addition to its role in ADP-induced platelet aggregation, P2Y 12 (Figure 1) also mediates the potentiation of platelet secretion induced by strong agonists, which is independent of the formation of large aggregates and thromboxane A 2 synthesis 2 ; the stabilization of thrombin-induced platelet aggregates 2 ; shear-induced platelet aggregation 2 ; and the inhibition of the antiplatelet effects of the natural regulator of platelet function, prostacyclin. 3In contrast to P2Y 1 , P2Y 12 has a very selective tissue distribution, making it an attractive molecular target for therapeutic intervention.Indeed, P2Y 12 is the target of efficacious antithrombotic agents.
Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy
Authors: B T Gjertsen, P Schöffski
Journal: Leukemia (2014)

Owing to their integral involvement in cell cycle regulation, the Polo-like kinase (Plk) family, particularly Plk1, has emerged as an attractive therapeutic target in oncology. In recent years, several Plk1 inhibitors have been developed, with some agents showing encouraging results in early-phase clinical trials. This review focuses on volasertib (BI 6727; an investigational agent), a potent and selective Plk inhibitor. Volasertib has shown promising activity in various cancer cell lines and xenograft models of human cancer. Trials performed to date suggest that volasertib has clinical efficacy in a range of malignancies, with the most promising results seen in patients with acute myeloid leukemia (AML). Encouragingly, recent phase II data have demonstrated that volasertib combined with low-dose cytarabine (LDAC) was associated with higher response rates and improved event-free survival than LDAC alone in patients with previously untreated AML. Based on these observations, and its presumably manageable safety profile, volasertib is currently in phase III development as a potential treatment for patients with AML who are ineligible for intensive remission induction therapy. Given that many patients with AML are of an older age and frail, this constitutes an area of major unmet need. In this review, we discuss the biologic rationale for Plk1 inhibitors in cancer, the clinical development of volasertib to date in solid tumors and AML, and the future identification of biomarkers that might predict response to volasertib and help determine the role of this agent in the clinic.
Serum Levels of Lipoprotein(a) in Patients With Well-Controlled Non-Insulin-Dependent Diabetes Mellitus
Authors: J. Joven, E. Vilella
Journal: JAMA (1991)

<h3>To the Editor.—</h3> We read with interest the data contained in a work by Bruckert et al<sup>1</sup>recently published inThe Journal. The authors suggested a relationship between diabetes mellitus and serum lipoprotein(a) (Lp[a]) levels. They also reported a dramatic decrease in Lp(a) levels following control of blood glucose levels in 10 insulin-dependent diabetic patients. These data are striking because it is generally thought that serum Lp(a) levels are genetically determined and are not influenced by hypolipidemictreatment. A possible role of insulin in the relatively unknown metabolism of Lp(a) is suggested. One of the main reasons for studying diabetic hyperlipoproteinemia has been its possible relationship to and role in the development of atherosclerosis, and Lp(a) has been recently recognized as an independent risk factor for the development of ischemic heart disease.<sup>2,3</sup>In a recent research protocol<sup>4</sup>we did not include the measurement of serum Lp(a)
Peanut Sublingual Immunotherapy (SLIT) Results in Sustained Unresponsiveness in a Subset of Peanut Allergic Children
Authors: Edwin H. Kim, Pamela H. Steele, Michael D. Kulis, Ayeshia Beavers, Deanna K. Hamilton, Rishu Guo, Brian P. Vickery, A. Wesley Burks
Journal: Journal of Allergy and Clinical Immunology (2015)
A Randomized Active-Controlled Study Comparing the Efficacy and Safety of Vernakalant to Amiodarone in Recent-Onset Atrial Fibrillation
Authors: A. John Camm, Alessandro Capucci, Stefan H. Hohnloser, Christian Torp-Pedersen, Isabelle C. Van Gelder, Brian Mangal, Gregory Beatch
Journal: Journal of the American College of Cardiology (2011)
Acute Intermittent Hyperparathyroidism With Hemorrhage Into a Parathyroid Adenoma
Authors: John W. DeGroote
Journal: JAMA (1969)

Emergency parathyroidectomy effected a successful cure of a patient with severe hypercalcemia due to acute hyperparathyroidism. This patient experienced a spontaneous remission of probable acute hyperparathyroidism nine months prior to surgery. It is noted that painful hemorrhage into a parathyroid adenoma coincident with the clinical symptoms of acute hypercalcemia is exceedingly rare.
Transforming Growth Factor- β<sub>1</sub> Induces Phenotypic Modulation of Human Lung Fibroblasts to Myofibroblast Through a c-Jun-NH<sub>2</sub>-Terminal Kinase-Dependent Pathway
Authors: SHU HASHIMOTO, YASUHIRO GON, IKUKO TAKESHITA, KEN MATSUMOTO, SHUICHIRO MARUOKA, TAKASHI HORIE
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Myofibroblasts play an important role in the fibrogenic process of pulmonary fibrosis. Transforming growth factor (TGF)- β is well known to induce the phenotypic modulation of fibroblasts to myofibroblasts; however, the intracellular signal regulating induction of the myofibroblastic phenotype of human lung fibroblasts (HLF) has not been determined. In the present study, we examined the role of the mitogen-activated protein kinase (MAPK) superfamily in inducing the phenotypic modulation of HLF to myofibroblasts characterized by α –smooth-muscle actin expression, in order to clarify this issue. The results showed that: (1) TGF- β1 caused the phenotypic modulation of HLF to myofibroblasts in a dose- and a time-dependent manner; (2) TGF- β1 induced increases in c-Jun-NH2- terminal kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (Erk) phosphorylation and activity; (3) the inhibitors CEP-1347, SB 203580, and PD 98059 attenuated TGF- β1–induced JNK, p38 MAPK, and Erk activity, respectively; and (4) CEP-1347, but not SB 203580 or PD 98059, attenuated the TGF- β1–induced phenotypic modulation of HLF to myofibroblasts in a dose-dependent manner. These results indicate that TGF- β1 is capable of inducing the myofibroblastic phenotype of HLF, and that JNK regulates the phenotypic modulation of TGF- β1–stimulated HLF to myofibroblasts.
Nephrotic syndrome in the tropics.
Authors: R. G. Hendrickse, H. M. Gilles
Journal: BMJ (1970)

MDICBLOUNAL 681 be expected in patients with folic acid deficiency (clinical or subclinical).The find- ings of Kaimis, Sumrnerly, and Giles (per- sonal cormmunication to Marks and Shuster, 12 September, p. 618) and the demon- stration of malabsorption in the proximnal small bowel' which is the site of absorption of folic acid, would seem to indicate that, in addition to an increased demand, there may be malabsorption of folic acid in these patients which would further exacerbate folate deficiency.As correctable malabsorption of vitamin B12 has been described in patients with folic acid deficiency,9"0 it would seem likely that the malabsorption of vitamin B12 in patients with various skin diseases is also due to folic acid deficiency.I wonder whether the authors have repeated the study after a course of folic acid.It would also be interesting to see whether the small bowel dysfunction in dermatogenic enteropathy reverts to normal on folic acid therapy alone without local treatment of the rash.If it does (as I suspect) in addition to the local treatment of dermatosis early folic acid therapy would seem to be indicated in patients with enteropathy, even when there are no obvious haematological changes.Similar explanation probably holds true in enteropathy associated with various chronic debilitating illnesses and also in conditions where increased cellular proliferation is a predomiunant feature.-Iam, etc.,
Endoscopic retrograde cholangiopancreatography, but not esophagogastroduodenoscopy or colonoscopy, significantly increases portal venous pressure: direct portal pressure measurements through endoscopic ultrasound-guided cannulation
Authors: J. Buscaglia, E. Shin, J. Clarke, S. Giday, C. Ko, P. Thuluvath, P. Magno, X. Dray, S. Kantsevoy
Journal: Endoscopy (2008)

See also: Commentaire de travail de J. M. Buscaglia et al., pp. 670Endoscopy 2008; 40(08): 798-798DOI: 10.1055/s-0032-1306863
HEALTH TEACHING BY PHYSICIANS
Authors: Alma Nemir
Journal: JAMA (1949)

<h3>To the Editor:—</h3> One of the objectives of the American Medical Association which has been stressed a great deal lately is public health education. What may be a doctor's role in such a program? One of the finest avenues open is health teaching in a college or university. Our belated interest in public relations can receive impetus from this contact with the public, teaching hundreds of impressionable young students in a wholesome atmosphere away from the sickroom and office. Such an experience will be pleasurable and beneficial to all concerned. There are many fields of health taught in a university in which the knowledge of the physician is invaluable. At the University of Utah last year, three thousand students in a student body of ten thousand took courses in health. Except for a few hundred in the field of school health education, all these students were taught by busy practicing
Sperm donation in the UK
Authors: M. Hamilton, A. Pacey
Journal: BMJ (2008)

<h3>Background and objectives</h3> Mild hyponatremia is a common finding in older adults; however, the association of lower serum sodium with cognition in older adults is currently unknown. We determined whether lower normal serum sodium is associated with cognitive impairment and risk of cognitive decline in community-dwelling older men. <h3>Design, setting, participants, &amp; measurements</h3> Five thousand four hundred thirty-five community-dwelling men aged ≥65 years who participated in Osteoporotic Fractures in Men, a cohort study with a median follow-up for cognitive function of 4.6 years, were included in this analysis. Multivariable logistic regression was used to examine the association between baseline fasting serum sodium levels and the odds of prevalent cognitive impairment (cross-sectional analysis; modified Mini-Mental Status [3MS] score &lt;1.5 SD [&lt;84] below or Trail Making Test Part B time &gt;1.5 SD above the mean [&gt;223 seconds]) and cognitive decline (prospective analysis [<i>n</i>=3611]; decrease in follow-up 3MS score or increase in Trails B time &gt;1.5 SD of the mean score/time change [&gt;9 or &gt;67 seconds]). <h3>Results</h3> Participants were aged 74±6 years with a fasting mean serum sodium level of 141±3 mmol/L. Fifteen percent (<i>n</i>=274), 12% (<i>n</i>=225), and 13% (<i>n</i>=242) had prevalent cognitive impairment in tertiles 1, 2, and 3, respectively. After adjustment, lower serum sodium was associated with prevalent cognitive impairment (tertile 1 [126–140 mmol/L] versus tertile 2 [141–142 mmol/L], odds ratio [OR], 1.30; 95% confidence interval [95% CI], 1.06 to 1.61). Fourteen percent (<i>n</i>=159), 10% (<i>n</i>=125), and 13% (<i>n</i>=159) had cognitive decline in tertiles 1, 2, and 3, respectively. Lower serum sodium was also associated with cognitive decline (tertile 1 versus tertile 2, OR, 1.37; 95% CI, 1.06 to 1.77). Tertile 3 (143–153 mmol/L) was additionally associated with cognitive decline. Results were similar in sensitivity analyses according to clinical cut-offs and by quartiles. <h3>Conclusions</h3> In community-dwelling older men, serum sodium between 126–140, and 126–140 or 143–153 mmol/L, are independently associated with prevalent cognitive impairment and cognitive decline, respectively.
Cancer Screening in Older Persons
Authors: Cary P. Gross
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Doctors call for England's chief medical officer to resign over “NHS in crisis”
Authors: Zosia Kmietowicz
Journal: BMJ (2007)

Doctors' leaders have called for the resignation of the chief medical officer for England, Liam Donaldson, blaming him for a catalogue of disasters that is engulfing the NHS.

John Hyslop, chairman of the BMA's Central Consultants and Specialists Committee, who proposed the motion at the BMA's annual representatives' meeting, cited as reasons for Professor Donaldson to resign the disagreement between doctors and the Department of Health over doctors' regulation and the chaos created by the new system for allocating training places for junior doctors. Both were good ideas that had got “into problems because of mismanagement by the Department of Health,” he said.

Dr …