tbuckley/cabot-search huggingface dataset:
INFANT FEEDING METHOD AND ADOLESCENT PERSONALITY
Authors: RICHARD E. DAVIS, RENE A. RUIZ
Journal: American Journal of Psychiatry (1965)

1. The relationship or possible lack of relationship between infant feeding method and certain adolescent characteristics is discussed. Previous emphasis on a sucking-feeding experience as a possible vital factor in early and subsequent personality development is noted. 2. In order to study possible correlations between adolescent physical characteristics, academic achievement and some personality factors, four groups of 20 boys and girls are studied, each group representing one of the four possible feeding methods (breast, bottle, cup and a mixture of these). 3. Results, or rather lack of a meaningful pattern of results, are interpreted as suggesting that infant feeding method is relatively independent of subsequent developmental characteristics, and also, that failure to experience a sucking-feeding type of experience during infancy does not obviously impair later psychological functioning. 4. The single inconsistent but statistically significant finding, that breast-fed girls in this population scored more "pathological" scale elevations on the MMPI than did cup-fed girls, is presented but not interpreted.
The difficult choice of treatment for poorly controlled maturity onset diabetes: tablets or insulin?
Authors: I Peacock, R B Tattersall
Journal: BMJ (1984)

Patients with maturity onset diabetes that is poorly controlled on maximal doses of oral hypoglycaemic agents are difficult to treat. A prospective randomised crossover study was performed in 58 predominantly non-obese patients on maximal doses of glibenclamide or metformin, or both, to find out if insulin would improve control or well being. The patients were given daily injections of up to 48 units of highly purified porcine lente insulin. Glycaemic control was improved by 15% or more in only 18 patients; 14 others felt better but their diabetes was no better controlled. Those whose control was improved by insulin could not be distinguished by age, duration of diabetes, body mass index, or their own treatment preference. C peptide concentrations, however, did help predict the response to insulin, the fasting C peptide to glucose ratio being considerably lower in those patients whose control was better on insulin. These findings suggest that a simple insulin regimen does not necessarily lead to better glycaemic control in maturity onset diabetes. Nevertheless, a trial of insulin is often justified since it poses few practical difficulties and makes some patients feel better even if their control is not improved. A more complex regimen might improve control in more cases, but it might also be less acceptable to older patients.
Pulmonary vasoreactivity in animals with relatively increased pulmonary blood flow
Authors: L. M. Linde, S. J. Goldberg, M. Takahashi, K. Momma, G. Groveman
Journal: Cardiovascular Research (1970)

Journal Article Pulmonary vasoreactivity in animals with relatively increased pulmonary blood flow Get access Leonard M. Linde, Leonard M. Linde From the Department of Pediatrics, Division of Cardiology, UCLA School of Medicine, Los Angeles, California 90024, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Stanley J. Goldberg, Stanley J. Goldberg From the Department of Pediatrics, Division of Cardiology, UCLA School of Medicine, Los Angeles, California 90024, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Masato Takahashi, Masato Takahashi From the Department of Pediatrics, Division of Cardiology, UCLA School of Medicine, Los Angeles, California 90024, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Kazua Momma, Kazua Momma From the Department of Pediatrics, Division of Cardiology, UCLA School of Medicine, Los Angeles, California 90024, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar George Groveman George Groveman From the Department of Pediatrics, Division of Cardiology, UCLA School of Medicine, Los Angeles, California 90024, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 4, Issue 1, January 1970, Pages 99–104, https://doi.org/10.1093/cvr/4.1.99 Published: 01 January 1970 Article history Accepted: 10 July 1969 Published: 01 January 1970
Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia
Authors: Chris Saddler, Peter Ouillette, Lisa Kujawski, Sanjeev Shangary, Moshe Talpaz, Mark Kaminski, Harry Erba, Kerby Shedden, Shaomeng Wang, Sami N. Malek
Journal: Blood (2007)
Improved Survival in a Cohort of Trial Participants with Metastatic Castration-resistant Prostate Cancer Demonstrates the Need for Updated Prognostic Nomograms
Authors: Aurelius Omlin, Carmel Pezaro, Deborah Mukherji, Amy Mulick Cassidy, Shahneen Sandhu, Diletta Bianchini, David Olmos, Roberta Ferraldeschi, Gal Maier, Emilda Thompson, Chris Parker, Gerhardt Attard, Johann de Bono
Journal: European Urology (2013)
Tapping fracture of tibia.
Authors: T B Young
Journal: BMJ (1984)

Tapping fracture of tibia An 18 year old man had a painful right shin after having been kicked playing football.The area was swollen, bruised, and tender, but no abnormality was seen on x ray examination.He was discharged.Pain per- sisted and increased while he was dancing eight days after the injury.Later his right leg gave way with a loud snap.X ray examination showed a tibial fracture.The fracture was undoubtedly caused by the kick, but intact, thick periosteum prevented displacement until the dancing.
Expression of ΔNp73 and TAp73α Independently Associated with Radiosensitivities and Prognoses in Cervical Squamous Cell Carcinoma
Authors: Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Annie Nga-Yin Cheung, Xiao-Yun Liao, Tsin-Wah Leung, Hextan Yuen-Sheung Ngan
Journal: Clinical Cancer Research (2006)

Abstract Purpose: The p73 gene produces different protein isoforms using alternative promoters and splicing, which have different biological characteristics. This study was to investigate the expression patterns of two distinct p73 isoforms (ΔNp73 and TAp73α) in cervical squamous cell carcinomas (SCC) and the relationship between their expressions and prognostic significance in cervical SCC patients. Experimental Design: We investigated the protein expressions of ΔNp73 and TAp73α in 117 cervical SCC and 113 normal cervical tissues using immunohistochemistry. The expression levels were analyzed with clinical variables and patients' survival. Results: ΔNp73and TAp73α were significantly overexpressed in cervical SCC compared with those in normal cervical epithelium (P &amp;lt; 0.001). However, their expressions were inversely correlated (P &amp;lt; 0.001, R = −0.368) and associated with differential tumor radiosensitivity. Overexpression of ΔNp73 was significantly found in SCC resistant to irradiation (P &amp;lt; 0.001), whereas increase of TAp73α expression was observed in the majority of SCC sensitive to irradiation (P &amp;lt; 0.001). Multivariate and survival analyses indicated that the expressions of ΔNp73 and TAp73α were independently associated with prognosis: ΔNp73 was associated with recurrence of the disease [P = 0.001; odds ratio (OR), 4.857] and an adverse outcome (P = 0.012; OR, 4.676), whereas TAp73α predicted a better survival of cervical SCC patients (P = 0.018; OR, 0.065). Conclusions: The p73 gene might be an important determinant of cellular response to irradiation. The expressions of the two main isoforms (ΔNp73 and TAp73α) might be potential markers for predicting the prognosis and sensitivity to radiotherapy in patients with cervical SCC.
Uniquantal Release through a Dynamic Fusion Pore Is a Candidate Mechanism of Hair Cell Exocytosis
Authors: Nikolai M Chapochnikov, Hideki Takago, Chao-Hua Huang, Tina Pangršič, Darina Khimich, Jakob Neef, Elisabeth Auge, Fabian Göttfert, Stefan W Hell, Carolin Wichmann, Fred Wolf, Tobias Moser
Journal: Neuron (2014)
Abstract 4106: Methods for the development of carcinoid cell lines and carcinoid associated fibroblasts
Authors: Sceusi L. Eric, Asif Rashid, Yunfei Zhou, Shaija Samuel, Fan Fan, Ling Xia, Xiang-Chang Ye, Jia Lu, Federico Tozzi, Puja Gaur, James Yao, Raymond Meyn, Lee M. Ellis
Journal: Cancer Research (2010)

Abstract Background: Research in carcinoid and neuroendocrine tumors (NETs) is limited by the lack of existing midgut derived cell lines. The two existing NET cell lines, BON and H727, are foregut derived. Foregut NETs are phenotypically distinct from midgut NETs, thus the development of a midgut derived NET cell line is of critical importance. Human NETs contain areas of stroma that likely effect carcinoid cell growth. In other types of cancer, cancer associated fibroblasts (CAFs) have been shown to secrete factors that mediate tumor cell growth. In our preliminary studies, cultured human NET cells showed better attachment to plates when they were in close association with fibroblasts. Unfortunately, the relatively slow growth of NET cells allows fibroblast overgrowth and ultimately detachment of the cancer cells. We have developed a novel approach to processing and culturing NET cells through the isolation of autologous CAFs and their use as irradiated feeder layers. Methods: Human NET surgical specimens are procured under sterile conditions and processed in our lab. The tissue is digested to a single cell suspension. Anti-fibroblast labeled beads (Miltenyi Biotec) are used to separate CAFs from tumor cells. CAFs are then cultured and irradiated to produce feeder layers for the tumor cells. The NET cells are initially maintained on extracellular matrix protein coated plates and then plated on top of the CAF monolayer. Results: CAFs in culture can survive 40 Gy of irradiation and will not proliferate after this treatment. These cells were viable at 12 days, at which point they were split. These irradiated fibroblasts were able to reattach to standard culture flasks and were viable, but did not proliferate after splitting, while the non-irradiated CAF controls had reached confluence by day 12 of this second passage. We currently have 5 patient NET samples that have been processed and plated in vitro on autologous CAFs. NET cells can then be separated from the irradiated fibroblasts using standard trypsinization followed by fibroblast separation using anti-fibroblast beads as described above. The tumor cells can then be used for analysis or further culturing. Early observations shows that the cancer cells appear more elongated and flattened when adjacent to fibroblasts, possibly indicating better attachment and survival. Conclusions: While NET cells remain difficult to culture, we have developed a system that utilizes autologous CAFs in our efforts to potentially establish new NET cell lines for in vitro and in vivo studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4106.
111In platelet imaging of left ventricular thrombi. Predictive value for systemic emboli.
Authors: J R Stratton, J L Ritchie
Journal: Circulation (1990)

To determine whether a positive indium 111 platelet image for a left ventricular thrombus, which indicates ongoing thrombogenic activity, predicts an increased risk of systemic embolization, we compared the embolic rate in 34 patients with positive 111In platelet images with that in 69 patients with negative images during a mean follow-up of 38 +/- 31 (+/- SD) months after platelet imaging. The positive and negative image groups were similar with respect to age (59 +/- 11 vs. 62 +/- 10 years), prevalence of previous infarction (94% vs. 78%, p less than 0.05), time from last infarction (28 +/- 51 vs. 33 +/- 47 months), ejection fraction (29 +/- 14 vs. 33 +/- 14), long-term or paroxysmal atrial fibrillation (15% vs. 26%), warfarin therapy during follow-up (26% vs. 20%), platelet-inhibitory therapy during follow-up (50% vs. 33%), injected 111In dose (330 +/- 92 vs. 344 +/- 118 microCi), and latest imaging time (greater than or equal to 48 hours in all patients). During follow-up, embolic events occurred in 21% (seven of 34) of patients with positive platelet images for left ventricular thrombi as compared with 3% (two of 69) of patients with negative images (p = 0.002). By actuarial methods, at 42 months after platelet imaging, only 86% of patients with positive images were embolus free as compared with 98% of patients with negative images (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Imaging the inflammatory response to acute myocardial infarction in man using indium-111-labeled autologous platelets.
Authors: R A Davies, M L Thakur, H J Berger, F J Wackers, A Gottschalk, B L Zaret
Journal: Circulation (1981)

The feasibility of imaging the inflammatory response to acute transmural myocardial infarction in man using biologically active indium-111 (111In)-labeled autologous leukocytes was assessed in 36 patients. Indium-111 leukocytes (approximately 500 microCi) were injected i.v. 18-112 hours after the onset of chest pain. Cardiac imaging was performed 24 hours later with a mobile gamma camera. Twenty-one patients had positive images and 15 had negative images. The percent of positive images increased as the interval between infarction and 111In-leukocyte injection shortened; all patients injected within 24 hours of infarction had positive images. Patients with positive images were injected with 111In leukocytes earlier after infarction (mean +/- SEM, 43 +/- 4 vs 63 +/- 7 hours; p less than 0.05) and were younger (53 +/- 2 vs 65 +/- 3 years; p less than 0.05) than those with negative images. Several other parameters that could possibly have affected the imaging results were examined and were not significantly different in patients with positive and negative images. These included peak serum creatine kinase, location of infarction, incidence of pericarditis, use of antiinflammatory drugs (aspirin and indomethacin) or membrane-active antiarrhythmic drugs (lidocaine and procainamide), peripheral leukocyte count and cell labeling efficiency. The function of the labeled cell was similar in patients with positive and negative images. Six patients with acute infarction serving as controls and given free 111In oxine and six patients with stable coronary artery disease given 111In leukocytes all had negative cardiac images.
Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway
Authors: Xiufeng Pang, Zhengfang Yi, Jing Zhang, Binbin Lu, Bokyung Sung, Weijing Qu, Bharat B. Aggarwal, Mingyao Liu
Journal: Cancer Research (2010)

Understanding the molecular basis and target of traditional medicine is critical for drug development. Celastrol, derived from Trypterygium wilfordii Hook F. ("Thunder of God Vine"), a traditional Chinese medicine plant, has been assigned anticancer activities, but its mechanism is not well understood. Here, we investigated whether Celastrol could inhibit angiogenesis-mediated tumor growth and, if so, through what mechanism. When given s.c. to mice bearing human prostate cancer (PC-3 cell) xenografts, Celastrol (2 mg/kg/d) significantly reduced the volume and the weight of solid tumors and decreased tumor angiogenesis. We found that this agent inhibited vascular endothelial growth factor (VEGF)-induced proliferation, migration, invasion, and capillary-like structure formation by primary cultured human umbilical vascular endothelial cells (HUVEC) in a dose-dependent manner. Furthermore, Celastrol abrogated VEGF-induced sprouting of the vessels from aortic rings and inhibited vascular formation in the Matrigel plug assay in vivo. To understand the molecular mechanism of these activities, we next examined the signaling pathways in treated HUVECs and PC-3 tumor cells. Celastrol suppressed the VEGF-induced activation of AKT, mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase (P70S6K). Additionally, we found that Celastrol inhibited the proliferation of prostate cancer cells and induced apoptosis, and these effects correlated with the extent of inhibition of AKT/mTOR/P70S6K signaling. Taken together, our results suggest that Celastrol targets the AKT/mTOR/P70S6K pathway, which leads to suppression of tumor growth and angiogenesis.
BITES FROM COPPERHEAD SNAKES
Authors: Gilman R. Davis
Journal: JAMA (1910)

In response to the suggestion of Dr. Prentiss Willson, 1 that physicians should report cases of poisoning by copperhead snakes, I will report three cases. The mountains of West Virginia are full of copperhead snakes, and bites by them are frequent, many of which are treated by domestic remedies without calling a physician. The fact that patients generally recover indicates that the wounds are not serious.  To be efficacious, the prophylactic treatment of a snake bite must be immediate. The first thing to do is to grasp the limb on the proximal side, close to the wound and substitute constriction by a handkerchief or cord for the pressure of the fingers as soon as possible. Rapid and shallow stabs with a sharp-pointed penknife should then be made in and about the wound and strong suction applied by the mouth. This method involves the risk of sepsis, not only from the
Hepatitis C in asymptomatic blood donors
Authors: H J Alter, C Conry-Cantilena, J Melpolder, D Tan, Mark Van Raden, D Herion, D Lau, J H Hoofnagle
Journal: Hepatology (1997)

Among 248 asymptomatic blood donors positive for antibody to hepatitis C virus (anti-HCV) enrolled in a long-term prospective study, 86% had chronic HCV infection and 14% appeared to have recovered as assessed by serial determinations of serum alanine aminotransferase (ALT) levels and HCV RNA by polymerase chain reaction. Established parenteral risk factors for HCV transmission were identified in 75% of donors. In addition, there was a strong independent association between HCV positivity and cocaine snorting, suggesting that shared snorting devices may be a covert route of parenteral transmission. Ear piercing in males was also significantly associated with transmission. There was no evidence for sexual spread. Although the majority of HCV carriers had both biochemical and histological evidence of chronic viral hepatitis, the extent of liver injury was generally mild. Among a larger population of 280 HCV RNA-positive donors, 17% had repeatedly normal ALT levels, 45% had levels that did not exceed twice, and only 22% had levels that exceeded five times the upper limit of the normal range. Among 81 patients who underwent liver biopsy, only 13% had evidence of severe hepatitis (8%) or cirrhosis (5%), despite a duration of infection that generally exceeded 15 years. No severe histological lesions were observed in blood donors with chronic HCV infection who had repeatedly normal ALT levels. In both donors and blood recipients, the frequency of severe morbidity or mortality related to HCV infection was less than 10% during the first two decades of infection. Further long-term studies are required to see if the progression to severe outcomes continues to accrue at this slow pace or whether it accelerates during subsequent decades.
A 44-Year-Old Woman With Borderline Personality Disorder
Authors: John M. Oldham
Journal: JAMA (2002)

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The Evolution of GABAA Receptor–Like Genes
Authors: Shui-Ying Tsang, Siu-Kin Ng, Zhiwen Xu, Hong Xue
Journal: Molecular Biology and Evolution (2006)

The inhibitory ligand-gated ion channel family of receptors, including the type A γ-aminobutryic acid (GABAA) and glycine receptors, mediates inhibitory neurotransmissions in the central nervous system. In this study, GABA receptor (GABR) evolution was explored through comparative genomics using genomes that span divergent lineages. GABAA/Gly receptor–like (GRL) gene sequences were retrieved from the genomes of various species ranging from mammal to fish to worm and subjected to cross-species comparison. All vertebrate GRL gene sets in the study but no invertebrate ones exhibit the extensive and conserved pattern of gene clustering that is characteristic of human GABR genes, indicating that the gene clusters were established early in vertebrate evolution, after divergence from the invertebrates. Moreover, the vertebrate gene structure is highly conserved with a basic 9–coding exon structure, whereas, as well as being diverse in copy numbers and chromosomal loci, the invertebrate GRL genes display a variety of gene structures. Remarkably, the invertebrates each possess a unique GRL gene pair that lies in neighboring loci within their respective genomes: zc482.5 and zc482.1 in roundworm, CG8916 and CG17336 in fruitfly, Ci4249 and Ci4254 in Ciona, and these were revealed by phylogenetic analysis to be homologous to human GABR α and β subunits, respectively. The phylogenetic classification of these genes is also corroborated by experimental ligand-binding measurements using recombinant gene products. Furthermore, the 3 invertebrate gene pairs harbor characteristic key residues and exhibit similarities in intron positions to their vertebrate counterparts. The results strongly indicate that such a gene pair originally existed in the bilaterian ancestor from which all 3 phyla evolved and suggest that the extant GABR clusters arose from an ancestral α–β subunit gene pair gave rise to the extant GABR clusters.