tbuckley/cabot-search huggingface dataset:
BLOOD SUGAR IN RELATION TO INSULIN REACTIONS
Authors: Genevieve Stearns
Journal: JAMA (1925)

Diabetic children usually show symptoms of insulin shock when the blood sugar reaches a value of from 0.050 to 0.040 per cent Recently, however, we have observed two children whose venous blood sugars reached much lower values without any apparent signs of shock. The blood sugar was determined in all cases by the method of Folin and Wu, 1 with the exception that dilutions to 6 or 12.5 c.c. were used when the sugar content was very low. Pfanstiehl's chemically pure special glucose was used in making the standards.  M. B., a girl, aged 4 years, showed on two occasions blood sugar values of 0.036 and 0.042 per cent., respectively, without any noticeable evidence of shock. With typical beginning insulin reaction—i. e., the child fully conscious, though drowsy, flushed, and perspiring freely, and unable to walk alone—the blood sugar was 0.025 per cent.  Similar observations were noted in the case
Systemic lupus erythematosus in a multiethnic US cohort LUMINA (XLI): factors predictive of self-reported work disability
Authors: A M Bertoli, M Fernandez, G S Alarcon, L M Vila, J D Reveille
Journal: Annals of the Rheumatic Diseases (2006)

<b>Objective:</b> To examine the risk factors for self-reported work disability in patients from the LUpus in MInorities: NAture vs. Nurture cohort with systemic lupus erythematosus (SLE). <b>Methods:</b> Patients with SLE of Hispanic (Texas and Puerto Rico), African American and Caucasian ethnicity were studied. Work disability was defined by patients' self-report. Only patients known to be employed at the baseline visit were included. The probabilities of self-reporting work disability over time were examined by the Kaplan–Meier method; differences between ethnic groups were examined by the log-rank test. The relationship of baseline socioeconomic–demographic, clinical, behavioural and psychological features with work disability was examined by standard statistical tests. Variables with p⩽0.10 in these analyses were examined by logistic regression. <b>Results:</b> The rate of self-reported work disability among the 273 patients studied was 19% at 5 years; it was numerically higher for the African Americans (25%) than for the Hispanics from Texas (19%) and the Caucasians (18%). The rate for the Hispanics from Puerto Rico was 7% at 2 years; 5-year rates could not be estimated for this ethnic subgroup (shorter follow-up in the cohort). In the regression analysis, age, male sex, poverty, total disease duration, disease activity and damage accrual were predictors of work disability. <b>Conclusions:</b> The rate of work disability was 19% at 5 years. Patients with SLE with more severe disease and with lower socioeconomic status are at high risk of becoming disabled. The toll SLE imposes could possibly be reduced in patients at risk if, in addition to medical treatment, services needed to overcome their disadvantageous socioeconomic status are provided.
Mortality and immortality
Authors: T. Dalrymple
Journal: BMJ (2011)

The Prix Goncourt, whose British equivalent is the Booker prize, was won in 2001 by a doctor, Jean-Christophe Rufin, for his historical novel Rouge Bresil . The author has had a remarkable career; he is what the French call a surdoue —a prodigy.

An early member of Medecins Sans Frontieres, Rufin has worked in Africa, Latin America, and Asia. A consultant in neurology in Paris, he has also been French cultural attache in Brazil and French ambassador to Senegal. He has fulfilled many administrative and academic duties, learnt several languages, and written 15 books, translated into many tongues, that have sold millions of copies worldwide. He became an immortel , one of the 40 members of the Academie Francaise, in …
Stories from the Wards
Authors: I. McClure
Journal: BMJ (2003)

BBC Radio 4, 13, 14, and 21 December at 7 45pm Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Medicine has always provided a rich seam for fiction, ranging from Chekhov's sublime short stories, to the ridiculous romances of Mills and Boon. To the public what happens in hospitals is a permanent source of intrigue and fantasy, serviced by a huge production of medical fiction in all possible formats. The ancient human need to hear or watch a story unfold remains undiminished and medicine is a compelling subject. But how often do we get an opportunity to hear, truthfully, from … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Anatomical Drawings From the Royal Library, Windsor Castle
Authors: Mark D. Altschule
Journal: JAMA (1985)

<h3>Leonardo on the Human Body,</h3> by Leonardo da Vinci, 506 pp, with illus, paper, $10.95, New York, Dover Publications Inc, 1983. These two books differently emphasize Leonardo's genius as artist and anatomist. One is the elegant catalogue of the exhibit of 50 sheets of Leonardo's drawings presented at the Metropolitan Museum of Art in early 1984. The exhibition comprised perhaps 25% of the Leonardo holdings of the Royal Library in Windsor Castle. The illustrations are illuminated by the explanatory notes of Kenneth Keele and Jane Roberts. Keele has an established reputation as an authority on Leonardo as an anatomist. Keele also contributes five pages of general comment, and there are brief comments by others. The book is intended to delight the eye, rather than nourish the brain, and it succeeds. The other book comprises 215 sheets of drawings with four scholarly essays on general matters plus comments on the plates,
ACNE AGMINATA (CROCKER)
Authors: W. JENKINS OLIVER
Journal: British Journal of Dermatology (1931)

Journal Article ACNE AGMINATA (CROCKER) Get access W. JENKINS OLIVER, M.A., B.M., M.R.C.P. W. JENKINS OLIVER, M.A., B.M., M.R.C.P. University Dermatological Clinic, Rigshospital, Copenhagen: Prof. C. Rasch Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 43, Issue 8-9, 1 August 1931, Pages 400–414, https://doi.org/10.1111/j.1365-2133.1931.tb09522.x Published: 01 August 1931
Acute Heart Failure Syndromes: Emergency Department Presentation, Treatment, and Disposition: Current Approaches and Future Aims
Authors: Neal L. Weintraub, Sean P. Collins, Peter S. Pang, Phillip D. Levy, Allen S. Anderson, Cynthia Arslanian-Engoren, W. Brian Gibler, James K. McCord, Mark B. Parshall, Gary S. Francis, Mihai Gheorghiade
Journal: Circulation (2010)
Measurement error, biases, and the validation of complex models for blood lead levels in children.
Authors: R J Carroll, C D Galindo
Journal: Environmental Health Perspectives (1998)

Measurement error causes biases in regression fits. If one could accurately measure exposure to environmental lead media, the line obtained would differ in important ways from the line obtained when one measures exposure with error. The effects of measurement error vary from study to study. It is dangerous to take measurement error corrections derived from one study and apply them to data from entirely different studies or populations. Measurement error can falsely invalidate a correct (complex mechanistic) model. If one builds a model such as the integrated exposure uptake biokinetic model carefully, using essentially error-free lead exposure data, and applies this model in a different data set with error-prone exposures, the complex mechanistic model will almost certainly do a poor job of prediction, especially of extremes. Although mean blood lead levels from such a process may be accurately predicted, in most cases one would expect serious underestimates or overestimates of the proportion of the population whose blood lead level exceeds certain standards.
A phase II study of ixabepilone plus trastuzumab for metastatic HER2-positive breast cancer.
Authors: SM Tolaney, J Najita, W Chen, J Savoie, M Fornier, IE Krop, EP Winer, C Bunnell
Journal: Cancer Research (2009)

Abstract Abstract #3137 Background: The epitholones are a new class of antineoplastic agents which are microtubule inhibitors with low susceptibility to several mechanisms of drug resistance. Ixabepilone (BMS-247550, aza-epothilone B) has demonstrated efficacy as monotherapy or in combination with capecitabine (in anthracycline- and taxane-pretreated metastatic breast cancer) and has recently been approved for use in refractory breast cancer. A multicenter NCI-sponsored study was conducted to analyze the safety and efficacy of the combination of ixabepilone with trastuzumab in patients with metastatic HER2-positive breast cancer.&amp;#x2028; Methods: This phase II nonrandomized study enrolled two cohorts of patients. Cohort 1 received no prior chemotherapy or trastuzumab for metastatic disease and cohort two received one or two prior trastuzumab-containing regimens for metastatic disease. Patients in each cohort received the same treatment regimen of ixabepilone and trastuzumab. Patients received ixabepilone 40 mg/m2 as a 3-hour continuous infusion on day 1 of a 21-day cycle plus trastuzumab once every 21 days. For the initial treatment of trastuzumab, patients received 8 mg/kg IV, and for all subsequent trastuzumab treatments 6 mg/kg. Treatment was continued until disease progression or unacceptable toxicity. Endpoints included response rate (RR), time to progression (TTP), toxicity, and predictive biomarkers.&amp;#x2028; Results: 39 women entered the study (median age 51, range 29-74) with 15 patients in cohort 1 and 24 patients in cohort 2. A median of 7 cycles of therapy were administered in each cohort. In cohort 1, there were 12 partial responses (PR), and 1 patient with stable disease for 5 months (SD). In cohort 2, there were 8 PRs and 9 patients with SD. Across both cohorts, the overall RR was 51%, with a clinical benefit rate (CR + PR + SD for at least 6 months) of 56%. Treatment-related toxicities included neuropathy (grade ≥2, 55%), myalgias (grade ≥2, 20%), anemia (grade ≥2, 18%), neutropenia (grade ≥2, 23%), and elevated transaminases (grade ≥2, 10%). There were no episodes of grade 2 or higher cardiac toxicity. Biomarker data will be presented.&amp;#x2028; Conclusion: This represents the first study of the combination of ixabepilone with trastuzumab for the treatment of metastatic HER2-positive breast cancer. These results suggest that the combination has an encouraging response rate as first- and subsequent- line therapy for metastatic breast cancer. Clinically significant neuropathy was the major toxicity, and appeared to be cumulative. Based on these results, further evaluation of ixabepilone plus trastuzumab is warranted. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3137.
Effects of Ouabain on Impaired Left Ventricular Function during Convalescence after Acute Myocardial Infarction
Authors: SHAHBUDIN H. RAHIMTOOLA, MICHAEL M. DIGILIO, M. ZIAD SINNO, HENRY S. LOEB, KENNETH M. ROSEN, ROLF M. GUNNAR
Journal: Circulation (1971)

The effects of intravenous ouabain (0.015 mg/kg body weight) were assessed in 13 patients 3-5 weeks after an uncomplicated acute myocardial infarction. The patients were not in clinical cardiac failure and were not having anginal pain. The mean ± sem of the values prior to (C) and 1 hour after ouabain (A) were: left ventricular end-diastolic pressure (LVEDP), C 18.6 ± 1.5, A 10.2 ± 1.4; stroke index, C 35.8 ± 3.9, A 39.5 ± 4.8; left ventricular stroke work (LVSW), C 99.4 ± 15.8, A 120.3 ± 19.5; mean rate of LV ejection (MRE), C 237.3 ± 21.9, A 274.5 ± 28.9; peak LV dp/dt, C 1,614 ± 141, A 2,145 ± 230; preejection period corrected for heart rate (PEP c ), C 135.8 ± 8.7, A 125.1 ± 9.2; left ventricular ejection time corrected for heart rate (LVET C ), C 407.9 ± 10.3, A 389.5 ± 9.2. These changes were significant ( P &lt; 0.05 for paired determinations). There were no significant changes in cardiac index, heart rate, mean arterial pressure, and systemic resistance. The reductions of LVEDP, PEP c , and LVET c and increases in SI, LVSW, MRE, and peak LV dp/dt show improvement of ventricular performance after ouabain and suggest that digitalis therapy could contribute to the management of patients convalescing after uncomplicated acute myocardial infarction.
Experimental Creutzfeldt-Jakob Disease Transmitted via the Eye with Infected Cornea
Authors: Elias E. Manuelidis, Jean N. Angelo, Edward J. Gorgacz, Jung H. Kim, Laura Manuelidis
Journal: New England Journal of Medicine (1977)

Scrapie of sheep, transmissible mink encephalopathy and Creutzfeldt-Jakob disease and kuru of man constitute the nosologic group of subacute spongiform virus encephalopathies.1 The possible transmission of Creutzfeldt-Jakob disease from person to person has been reported in a 55-year-old man in whom the disease developed 18 months after he received a corneal transplant from a donor who had died of a neurologic disorder later diagnosed as Creutzfeldt-Jakob disease.2 In 1974 infectivity was demonstrated in corneal tissues of hamsters dying of transmissible mink encephalopathy. After injection of infected corneal epithelium intracerebrally into healthy hamsters the disease developed.3 Successful transmission from a woman . . .
Swine flu grips northern and western India
Authors: S. Bhaumik
Journal: BMJ (2013)

<h3>Abstract</h3> <b>Objective</b>: To examine the hypothesis that the increase in fibrinogen concentration and respiratory infections in winter is related to seasonal variations in vitamin C status (assessed with serum ascorbate concentration). <b>Design</b>: Longitudinal study of individuals seen at intervals of two months over one year. <b>Setting</b>: Cambridge. <b>Subjects</b>: 96 men and women aged 65-74 years living in their own homes. <b>Main outcome measures</b>: Haemostatic factors fibrinogen and factor VIIC; acute phase proteins; respiratory symptoms; respiratory function. <b>Results</b>: Mean dietary intake of vitamin C varied from about 65 mg/24 h in winter to 90 mg/24 h in summer; mean serum ascorbate concentration ranged from 50 μmol/l in winter to 60 μmol/l in summer. Serum ascorbate concentration was strongly inversely related to haemostatic factors fibrinogen and factor VIIC as well as to acute phase proteins but not to self reported respiratory symptoms or neutrophil count. Serum ascorbate concentration was also related positively to forced expiratory volume in one second. An increase in dietary vitamin C of 60 mg daily (about one orange) was associated with a decrease in fibrinogen concentrations of 0.15 g/l, equivalent (according to prospective studies) to a decline of approximately 10% in risk of ischaemic heart disease. <b>Conclusion</b>: High intake of vitamin C has been suggested as being protective both for respiratory infection and for cardiovascular disease. These findings support the hypothesis that vitamin C may protect against cardiovascular disease through an effect on haemostatic factors at least partly through the response to infection; this may have implications both for our understanding of the pathogenetic mechanisms in respiratory and cardiovascular disease and for the prevention of such conditions. <h3>Key messages</h3> Key messages A winter increase in fibrinogen concentration has been associated with a winter increase in respiratory infection Vitamin C status is related to fibrinogen and factor VIIC concentrations as well as markers of infections including acute phase proteins and to respiratory function Maintaining adequate vitamin C intake—for example, by eating an extra orange daily—may reduce some of the seasonal variation in mortality Differences in vitamin C status, infection, and fibrinogen concentration might explain some of the observed socioeconomic differential in respiratory and cardiovascular disease
Augmentation of cardiac output and carotid blood flow by chest and abdomen phased compression cardiopulmonary resuscitation
Authors: E. KIMMEL, R. BEYAR, U. DINNAR, S. SIDEMAN, Y. KISHONT
Journal: Cardiovascular Research (1986)

Phased compression cardiopulmonary resuscitation, whereby the chest and abdomen are compressed sequentially, is a new approach to the classical cardiopulmonary resuscitation technique, which is based on the compression of the chest alone. Six dogs with cardiac arrest were treated by external chest and abdominal compression using a rigid plexiglas suit lined with flexible perithoracic and periabdominal bladders. Fast inflation and deflation of the two independent bladders, together with forced ventilation of the lung, generated phased pressure pulses. The physiological variables monitored throughout the experiment included central venous, left ventricular, and central arterial pressures, carotid blood flow, cardiac output, and acid base balance. The phased compression technique was performed with phased time lags of 0, 150, 300, 400, 600, 700, and 850 ms between the abdominal and thoracic pressure pulses. A random sequence of the different phased compression modes, each lasting for 3–10 minutes, was applied during the prolonged resuscitation procedure that lasted for up to 70 minutes. By starting the abdominal compression 300–400 ms before the thoracic compression the carotid flow index improved by 77% (from 13% with simultaneous compression to 23% with phased compression) and the cardiac output index increased by 65% (from 7.8% with simultaneous compression to 12.5%). The results provide insight into the chest pump concept and the role of intrathoracic and intra-abdominal pressures in generating improved blood circulation during cardiopulmonary resuscitation, and show the advantages of phased compression over chest compression alone and simultaneous chest and abdominal compression.
Cervicofacial Actinomycosis Report of Case
Authors: William H. Perlstein
Journal: New England Journal of Medicine (1953)

IN the following fairly typical case of cervicofacial actinomycosis, unrecognized for almost five years, a question of the value of various diagnostic and therapeutic methods arises.Case ReportIn September, 1944, a 30-year-old veteran experienced pain and swelling in the area of the right lower wisdom tooth. After ambulatory treatment for "recurrent attacks of pericoronitis" the patient was hospitalized from November, 1944, to February, 1945, and also from March to May, 1945, on account of supervening "submaxillary and cervical lymphadenitis." Discharged from the hospital as "improved," he was under ambulatory medical care until 1949.According to the hospital records no . . .
Brain Activation Patterns in Schizophrenic and Comparison Volunteers During a Matched-Performance Auditory Recognition Task
Authors: Henry H. Holcomb, Adrienne C. Lahti, Deborah R. Medoff, Martin Weiler, Robert F. Dannals, Carol A. Tamminga
Journal: American Journal of Psychiatry (2000)

The biological characteristics of schizophrenia are often studied by using functional imaging techniques. However, since volunteers with schizophrenia routinely fail to perform as accurately or as quickly as healthy volunteers, it is difficult to ascertain whether a particular deficit in blood flow to a brain region is due to behavior or to the underlying illness. In this report, investigators used an auditory recognition task to assess brain blood flow patterns and behavioral correlates of schizophrenic patient volunteers trained on the task.Twelve healthy volunteers and 18 volunteers with schizophrenia were trained to make tone frequency recognitions. Accuracy and stimuli were matched between groups. Participants were required to press a button to indicate whether a briefly presented tone was the high-frequency (1500 Hz) reference tone or one of a lower frequency level (level chosen to elicit an 80% accuracy score). Subjects underwent bolus [(15)O]H(2)O blood flow positron emission tomography during inactive rest, a sensory motor control condition, and the decision task. Blood flow patterns were assessed between conditions and between groups.As a group, the patients with schizophrenia (who performed as quickly and accurately as the comparison subjects) exhibited significantly less change in regional cerebral blood flow (rCBF) to the anterior cingulate and supplementary motor cortices when switching from the sensory motor control to the decision condition. There were also marked between-group differences in correlations between rCBF and response time. Whereas the comparison subjects exhibited progressively greater blood flow to the frontal cortex in association with longer response times, the schizophrenic patients exhibited progressively lower blood flow in conjunction with extended response times.The failure to appropriately enhance cingulate activity when engaged in a demanding task and the progressive, time-dependent decline in frontal blood flow suggest that patients with schizophrenia are unable to make optimal use of frontocingulate systems when maximally engaged in high-error tasks.
lodine-131 MIBG Uptake In Metastatic Medullary Carcinoma of the Thyroid A Patient Treated with Somatostatin
Authors: CHRISTINE A. KEELING, LAWRENCE V. BASSO
Journal: Clinical Nuclear Medicine (1988)

A 47-year-old man with multiple endocrine neoplasia (MEN) type 2a syndrome in whom metaiodobenzylguanidine (MIBG) concentrated in lesions from metastatic medullary carcinoma of the thyroid is reported. A somatostatin analogue (Sandostatin SMS 201-995) alleviated the symptoms of flushing and diarrhea associated with the elevated calcitonin levels but it did not alter either the course of the disease or the MIBG images. A review of the literature is presented of the noncatecholamine secreting tumors associated with MIBG uptake. Similarities between this case and metastatic carcinoid syndrome are discussed.
EFFECTS OF TRIFLUOPERAZINE IN AGED DEPRESSED FEMALE PATIENTS
Authors: GEORGE W. BROOKS, M. GLENN MACDONALD
Journal: American Journal of Psychiatry (1961)

It would appear that the incidence and severity of Parkinsonism in this age group is so high that trifluoperazine should be used very cautiously. Occurrence of 1 very dramatic recovery and 3 cases of gratifying improvement suggest that trifluoperazine may be useful in cases of chronic depression resistant to more usual therapies.
BRAIN SPECT FINDINGS IN UNUSUAL NON-PSYCHIATRIC SYNDROMES
Authors: B. Barron, M. Hovsepian, L. Lamki, L. Kramer, J. Wheless, Z. Kalisky, J. Willmore, V. Curtis, J. Grotta
Journal: Clinical Nuclear Medicine (1995)

Barron, B.; Hovsepian, M.; Lamki, L.; Kramer, L.; Wheless, J.; Kalisky, Z.; Willmore, J.; Curtis, V.; Grotta, J. Author Information