tbuckley/cabot-search huggingface dataset:
TBL1XR1/TP63: a novel recurrent gene fusion in B-cell non-Hodgkin lymphoma
Authors: David W. Scott, Karen L. Mungall, Susana Ben-Neriah, Sanja Rogic, Ryan D. Morin, Graham W. Slack, King L. Tan, Fong Chun Chan, Raymond S. Lim, Joseph M. Connors, Marco A. Marra, Andrew J. Mungall, Christian Steidl, Randy D. Gascoyne
Journal: Blood (2012)
Cross-sectional echocardiographic diagnosis and subclassification of univentricular hearts: imaging studies of atrioventricular valves, septal structures and rudimentary outflow chambers.
Authors: D J Sahn, J R Harder, R M Freedom, W J Duncan, R D Rowe, H D Allen, L Valdes-Cruz, S J Goldberg
Journal: Circulation (1982)

We reviewed anatomic observations (surgical or autopsy), angiograms and echocardiograms from 44 patients with documented univentricular hearts. Thirty-three patients had univentricular heart of left ventricular type with an outflow or rudimentary chamber. Five had univentricular heart of right ventricular type, and six had univentricular heart of indeterminate types without a rudimentary chamber. Univentricular heart was correctly diagnosed by two-dimensional echocardiography in all but two of the 44 patients, including 25 of 27 double-inlet univentricular hearts, all five with absent left and all 12 with absent right atrioventricular connection. One of the two blind trabecular pouches was missed on echocardiography; the other was not seen on the angiogram but was present at autopsy. In 30 of 33 patients, univentricular heart of left ventricular type was correctly identified by imaging an anterosuperior and leftward or rightward outlet chamber, and in four of five patients with univentricular heart of right ventricular type, the anomaly was correctly identified by imaging the inferior and posterior position of the rudimentary outflow chamber near the crux of the heart. Two-dimensional echocardiography provides detailed analysis of atrioventricular connections, main chamber morphology, and rudimentary chamber size and position of noninvasive diagnosis and anatomic subclassification of univentricular hearts.
A Case of Rupture of the Internal and Middle Coats of the Popliteal Artery, and Complete Rupture of the Popliteal Vein, for which Primary Amputation of the Thigh was Successfully Performed: With Remarks
Authors: W. Rivington
Journal: BMJ (1878)

blood-stream of a limb, and not into a vein ; consequently it had to pass through the capillary system of the limb, and so become intimately mixed with the circulating blood, before it arrived at the heart.It is this fact which affords the key to the understanding of the result.The tendency to coagulation developed itself slowly, and affected the whole mass of the blood, its effect being to increase the viscidity, and not to produce clots.It was only in a few cases that visible plugs could be
901-52 Ultrasonic Integrated Backscatter Cyclic Variations During Atrial Pacing in Patients with and without Coronary Artery Disease
Authors: Leonarda Galiuto, Venanzio F. Napoli, Cataldo Memmola, Vito Marangelli, Sabino Iliceto, Paolo Rizzon
Journal: Journal of the American College of Cardiology (1995)
Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children
Authors: Hans Verhoef, Clive E. West, Rob Kraaijenhagen, Silas M. Nzyuko, Rose King, Mary M. Mbandi, Susanne van Laatum, Roos Hogervorst, Carla Schep, Frans J. Kok
Journal: Blood (2002)
Acute Nitrobenzene Poisoning with Transient Amino-aciduria
Authors: W. E. Parkes, D. W. Neill
Journal: BMJ (1953)

BRmsH 653 seeing the patients soon afterwards there was less risk of their forgetting the facts or becoming confused about details. ResultsOf the 60 patients who were treated with an active anti- histamine preparation, 47 reported themselves as cured and six as improved.Thus 88% were either cured or improved by the treatment.In the control group, three patients regarded themselves as cured and four as improved, a total of 10%.Table I shows that no case of severe vomitingTABLE I.-Results of Treatment Treatment No. of No. No.No Cases Cured Improved Change Severe Vomiting Antihistamine .. 31 25 2 4 Inert tablet .. 33 Moderate Vomiting Antihistamine .. 17 12 3 2 Inert tablet .. 16 2 4 10 Nqusea and Heartburn Antihistamine .. 12 10 1 1 Inert tablet .. 11 1 10was affected by an inert preparation, and that it was in the cases of moderate vomiting that the inert tablets had most effect.Most of v the patients in the control series were subse- quently treated with antihistamines, when they showed a higher proportion of cured and improved (Table II).Thus TABLE II.-Control Cases Subsequently Treated with Antihistamines No. of Cases No. Cured No. Improved No Change 50 43 3 4out of 50 of these patients treated 86% were cured, 6%'were-improved, and only 8% showed no change.With this group, however, other factors may have affected the results.These patients were being treated at a somewhat later stage in pregnancy, and it was possible that time was effecting a cure.Also, as the antihistamine tablets they subsequently received were of a brighter colour than the inert tablets, they may well have deduced that they were receiving a more potent preparation, and so the factor of suggestion may have influenced the results.In most cases three days' treatment was insufficient to effect a permanent cure, and it was necessary to continue treatment for at least a fortnight, and sometimes for four weeks.No other treatment was given and no dietary restrictions were imposed.No adverse effects were noted from even a prolonged course, although occasionally some patients complained of drowsiness.
Possible upregulation of hypothalamic 5-hydroxytryptamine receptors in patients with postviral fatigue syndrome.
Authors: A. M. Bakheit, P. O. Behan, T. G. Dinan, C. E. Gray, V. O'Keane
Journal: BMJ (1992)

OBJECTIVE--To study the dynamic function of hypothalamic 5-hydroxytryptamine receptors in patients with postviral fatigue syndrome. DESIGN--Prospective comparison of patients with postviral fatigue syndrome with two control groups. SETTING--Department of neurology, University of Glasgow, Southern General Hospital; department of psychiatry, St James9s Hospital, Dublin. SUBJECTS--15 patients with postviral fatigue syndrome, 13 age and sex matched healthy subjects, and 13 patients with primary depression. MAIN OUTCOME MEASURES--Serum prolactin concentrations before and one, two, and three hours after administration of buspirone. RESULTS--Because of the effects of sex hormones on prolactin secretion data for men and women were analysed separately. There was no significant difference in baseline prolactin concentrations between patients with postviral fatigue syndrome and healthy subjects or those with primary depression. However, the percentage difference between peak and baseline values was significantly higher in patients with postviral fatigue syndrome than the control groups (one way analysis of variance: women, p = 0.003; men, p = 0.004). CONCLUSIONS--The results suggest upregulation of hypothalamic 5-hydroxytryptamine receptors in patients with postviral fatigue syndrome but not in those with primary depression. The buspirone challenge test may therefore be useful in distinguishing these two conditions. Larger studies are required to explore the potential value of drugs acting on central 5-hydroxytryptamine receptors in the treatment of patients with the postviral fatigue syndrome.
Long-Term Comparison of Everolimus-Eluting and Sirolimus-Eluting Stents for Coronary Revascularization
Authors: Lorenz Räber, Peter Jüni, Eveline Nüesch, Bindu Kalesan, Peter Wenaweser, Aris Moschovitis, Ahmed A. Khattab, Maryam Bahlo, Mario Togni, Stéphane Cook, Rolf Vogel, Christian Seiler, Bernhard Meier, Stephan Windecker
Journal: Journal of the American College of Cardiology (2011)
The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus
Authors: Garron T. Dodd, Amy A. Worth, Nicolas Nunn, Aaron K. Korpal, David A. Bechtold, Margaret B. Allison, Martin G. Myers, Michael A. Statnick, Simon M. Luckman
Journal: Cell Metabolism (2014)

Leptin is a critical regulator of metabolism, which acts on brain receptors (Lepr) to reduce energy intake and increase energy expenditure. Some of the cellular pathways mediating leptin's anorectic actions are identified, but those mediating the thermogenic effects have proven more difficult to decipher. We define a population of neurons in the dorsomedial hypothalamic nucleus (DMH) containing the RFamide PrRP, which is activated by leptin. Disruption of Lepr selectively in these cells blocks thermogenic responses to leptin and causes obesity. A separate population of leptin-insensitive PrRP neurons in the brainstem is required, instead, for the satiating actions of the gut-derived hormone cholecystokinin (CCK). Global deletion of PrRP (in a loxSTOPlox-PrRP mouse) results in obesity and attenuated responses to leptin and CCK. Cre-recombinase-mediated reactivation of PrRP in brainstem rescues the anorectic actions of CCK, but reactivation in the hypothalamus is required to re-establish the thermogenic effect of leptin.
Segregation analysis of Breast Cancer from the Cancer and Steroid Hormone Study: Histologic Subtypes
Authors: A. M. Goldstein, C. I. Amos
Journal: JNCI Journal of the National Cancer Institute (1990)

The segregation pattern of breast cancer in white families from the Cancer and Steroid Hormone Study was investigated. Families were categorized into four groups based on the histologic type of breast cancer in the probands: ductal cancer, lobular cancer, adenocarcinoma, and medullary cancer. The ductal cancer sample was further split into a premenopausal-proband and a postmenopausal-proband subset. Results for six complex segregation analyses are presented; the findings suggest heterogeneity in the transmission of breast cancer. For all analyses, there was no evidence for a multifactorial component in the mixed model, ie, a major locus plus other transmission, genetic and/or cultural. Interpretation of the medullary cancer, adenocarcinoma, and lobular cancer analyses does not permit discrimination among the major locus models. Segregation of breast cancer in the entire ductal sample was consistent with autosomal recessive transmission. In the ductal subanalyses, a recessive gene was sufficient to explain the breast cancer distribution when the proband had postmenopausal breast cancer. In contrast, when the proband had premenopausal breast cancer, the transmission model was consistent with a dominant major gene, with sporadic cases of disease [J Natl Cancer Inst 82:1911–1917,1990]
Serum concentrations of laminin in cirrhosis of the liver.
Authors: J Collazos, F Diaz, J Genolla
Journal: Gut (1993)

Laminin, a glycoprotein synthesised by Ito cells, has been considered a marker of fibrogenesis. The behaviour of laminin and clinical and laboratory data in 83 patients with cirrhosis were studied to find the factors associated with increases in this glycoprotein. There were increased concentrations of laminin in 62.7% of the patients (40% of the Child9s A, 64.5% of the Child9s B, and 75% of the Child9s C categories). Significant differences in laminin concentrations were found between the Child9s grades (p = 0.009) and between patients and controls (p &lt; 0.0001). Correlations were found between laminin concentrations and mean corpuscular volume, aspartate aminotransferase, aspartate aminotransferase: alanine aminotransferase ratio, alkaline phosphatase activity, bilirubin and glycocholic acid concentrations, and hypoalbuminaemia--that is, variables related to liver insufficiency and alcohol intake. Moreover, patients with an alcohol intake higher than 100 g/day had higher laminin concentrations than those with a lower intake (p = 0.03). Conversely, there was no significant association with portal hypertension. Multivariate analysis showed that mean corpuscular volume, bilirubin concentrations, and hypoalbuminaemia were independently associated with laminin concentrations. Poor degradation associated with liver insufficiency seems to play an important part in the increase in serum laminin concentrations in these patients.
Case report: 1‐deamino‐8‐D‐arginine vasopressin and cryoprecipitate in variant von Willebrand disease
Authors: Wahid T. Hanna, Joseph Slywka, Judith Dent, Zaverio M. Ruggeri, Theodore S. Zimmerman
Journal: American Journal of Hematology (1985)

Abstract The effect of infusing DDAVP and cryoprecipitate either singly or in combination was studied in a patient with variant von Willebrand disease. Both DDAVP and cryoprecipitate caused only partial correction in the hemostatic defect when used as a single agent. A combination of DDAVP and cryoprecipitate induced a complete correction of the hemostatic defect as well as factor VIII related properties.
Defining the Risks of Subclavian-Vein Catheterization
Authors: William D. Haire, Robert P. Lieberman
Journal: New England Journal of Medicine (1994)

Infusion of blood products, medications, and fluids and removal of blood for testing are essential in treating many critically ill patients. Central venous catheterization through the subclavian vein1 has facilitated such potentially life-saving treatments as high-dose chemotherapy for cancer, total parenteral nutrition, and long-term parenteral antibiotic therapy. Since subclavian-vein catheterization is performed millions of times annually, even uncommon complications of this procedure can affect large numbers of patients.Central venous catheterization is performed for three specific reasons: to infuse solutions that cannot be given through peripheral veins -- for example, in the case of total parenteral nutrition and some forms . . .
Prophylaxis for Stress-Related Gastric Hemorrhage
Authors: Jeffrey N. Martin
Journal: Annals of Internal Medicine (1995)

Letters15 April 1995Prophylaxis for Stress-Related Gastric HemorrhageThomas G. Cantu and Robyn G. KarlstadtThomas G. CantuSearch for more papers by this author and Robyn G. KarlstadtSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-8-199504150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The study by Ben-Menachem and colleagues [1] showed no differences among sucralfate, continuous-infusion cimetidine, or placebo in preventing stress-related mucosal damage for patients in a medical intensive care unit. However, several factors may have influenced the cimetidine results in this study, including the use of an inappropriately low initial infusion rate for cimetidine, the significantly lower use of enteral feeding in the cimetidine group, and a significantly higher rate of sepsis on admission to the intensive care unit for recipients of cimetidine. Another potential confounder is that although patients who received omeprazole within 24 hours of admission ...References1. Ben-Menachem T, Fogel R, Patel RV, Touchette M, Zarowitz BJ, Hadzijahic N, et al. Prophylaxis for stress-related gastric hemorrhage in the medical intensive care unit. A randomized, controlled, single-blind study. Ann Intern Med. 1994; 121:568-75. Google Scholar2. Maton PN. Omeprazole. N Engl J Med. 1991; 324:965-75. Google Scholar3. Martin LF, Booth FV, Karlstadt RG, Silverstein JH, Jacobs DM, Hampsey J, et al. Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. Crit Care Med. 1993; 21:19-30. Google Scholar4. Karlstadt RG, Iberti TJ, Silverstein J, Lindenberg L, Bright-Asare P, Rockhold F, et al. Comparison of cimetidine and placebo for the prophylaxis of upper gastrointestinal bleeding due to stress-related gastric mucosal damage in the intensive care unit. Journal of Intensive Care Medicine. 1990; 5:26-32. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1995Volume 122, Issue 8Page: 632-634KeywordsGastrointestinal hemorrhageGastrointestinal tractHead injuryHemorrhageIntensive care unitsMedical intensive care unitsMedical risk factorsNSAIDsProphylaxisSepsis Issue Published: 15 April 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Ampicillin rash and influenza.
Authors: I Gregg
Journal: BMJ (1973)

to an af.ernoon surgery.A general practi- tioner who holds no evening surgeries will force many patients to take time off work to visit hs doctor instead of coming to sur- gery in the evening after work.I presume Dr. Smith prefers to fall in line with the working hours of branches of the medical service working "9 to 5" rather than with his junior hospital colleagues or the majority of general practitioners.-Iam, etc.,
Of Attraction and Rejection — Asthma and the Microbial World
Authors: Erika von Mutius
Journal: New England Journal of Medicine (2007)

In the first half of the past century, it was thought that asthma was precipitated or prolonged by infection and that infection with several bacteria, including Streptococcus pneumoniae and Haemophilus influenzae, had a role in asthma.1 Some investigators had suggested that bacterial allergy or chronic focal infection could be a cause of asthma.2 More recently, population-based studies relating infections with Chlamydia pneumoniae and Mycoplasma pneumoniae to asthma severity encouraged a resurgent debate, but clinical trials involving various antibiotics failed to demonstrate sustained clinical benefit.1 To understand this debate we need to consider asthma and wheeze in children. The greatest incidence . . .
Inhibition of Lactation
Authors: M. R. Fell
Journal: BMJ (1969)

Mr. P.N. Gillibrand and Professor P.J. Huntingford report that quinestrol given as a simple 2-mg. or 4-mg. dose immediately after delivery failed to suppress lactation within eight days of delivery in five of eight patients receiving 2 mg.  and 13 of 19 given 4 mg. (21 December p. 769).  These findings conflict with mine.  I have recently completed a trial with this product and have found it efficient in inhibiting lactation.  The results of my trial are awaiting publication.  Through your columns I wish to record that lactation was completely inhibited during the immediate post-delivery lying-in period but there was no subsequent leakage of milk secretion or trouble with the breasts in these women.  This was confirmed by a follow-up questionary sent to the patients concerned some time after their discharge from hospital.(Full text)
IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans
Authors: Isabelle Isnardi, Yen-Shing Ng, Iva Srdanovic, Roja Motaghedi, Sergei Rudchenko, Horst von Bernuth, Shen-Ying Zhang, Anne Puel, Emmanuelle Jouanguy, Capucine Picard, Ben-Zion Garty, Yildiz Camcioglu, Rainer Doffinger, Dinakantha Kumararatne, Graham Davies, John I. Gallin, Soichi Haraguchi, Noorbibi K. Day, Jean-Laurent Casanova, Eric Meffre
Journal: Immunity (2008)
The New Ethics
Authors: Trisha Greenhalgh
Journal: BMJ (2004)

Mornings tend to drag for us academics, so let me tell you about a computer game that will help you while away the hours till lunch.

There's a new system for applying for research ethical approval (http://www.corec.org.uk/). Like most things these days apart from registering births or deaths (though I'm told the latter is coming), you are now encouraged to do it all online.

Start by scrutinising the New Operational Procedures (= how to fill the form in and where to …
Dolphins on the witness stand? The comparative psychology of strategic memory regulation
Authors: Morris Goldsmith, Asher Koriat
Journal: Behavioral and Brain Sciences (2003)

Smith et al. show that monkeys and dolphins can respond adaptively under conditions of uncertainty, suggesting that they monitor subjective uncertainty and control their behavior accordingly. Drawing on our own work with humans on the strategic regulation of memory reporting, we argue that, so far, the distinction between monitoring and control has not been addressed sufficiently in metacognitive animal research.
Reducing the length of stay in hospital.
Authors: M Ryan
Journal: BMJ (1986)

Unlike their British counterparts, Soviet health care planners have long adhered to a strategy of adding to the number of hospital beds each year. Consequently, the proportion of the population admitted to hospital has grown steadily; by 1983 this had reached the historically high level of 24'7%. Although the extra capacity has been advantageous in several respects, it can scarcely have encouraged rigorous assessment of traditional practices that entail the use of expensive inpatient facilities. Two key series of official statistics for 1974-81 support this contention. The first records that the average duration of stay during this period lengthened from 17-4 to 17 6 days in urban units and from 13*4 to 14*6 days in rural hospitals. The second series shows that only a marginal improvement occurred in the average number of days in a year on which a hospital bed was being used rather than lying empty: the figure rose slightly from 326 to 328 in urban areas and from 311 to 312 in the countryside. These data relate to all the units for which the Union Health Ministry is responsible, and hence to most Soviet hospitals.
Response of Serum Lipids and Lipoproteins of Man to Beta-Sitosterol and Safflower Oil
Authors: JOHN W. FARQUHAR, MAURICE SOKOLOW
Journal: Circulation (1958)

Previous studies in man have indicated that administration of either plant sterols or unsaturated dietary fats causes decreases in certain serum lipids. This report presents the results of a long-term 7-phase study of the comparative effects of the single and combined administration of plant sterols (β-sitosterol) and a highly unsaturated vegetable oil (safflower oil) in 15 ambulatory subjects. The serum lipid changes observed indicate that both agents act on the same low-density lipoprotein fraction, that the changes produced by β-sitosterol and by safflower oil are similar in magnitude, but that the combination has a 55 per cent greater effect than either agent alone, that the mechanisms of action of these 2 agents probably differ, and that the action of the safflower oil is probably not due to the amount of sitosterol it contains.
Reid's Controversy in Obstetrics and Gynecology—III
Authors: Ann B. Barnes
Journal: JAMA (1983)

Zuspan and Christian have admirably fulfilled their purpose to provide an enlightened exposition on current controversies in obstetric and gynecologic practice. To do this, they have enlisted an articulate group of contributing authors. Discussion of the management of carcinoma in situ of the cervix represents well-substantiated, extreme points of view. The middle ground between cancer precursors and the infectious origin of dysplasia needs more investigation. Conversely, those authors discussing obstetrical problems such as prenatal fetal monitoring and the management of preterm labor explore the middle ground of controversy in depth. Here it is clear that clinical trials of sufficient size and statistical power cannot be mounted to provide definitive answers. The shrewd application of new understanding of pathophysiology is well presented and critically evaluated, but the editors are too timid about exercising their prerogative. One does not need to reread the litany of obstetricians' current understanding of the sympathetic nervous
A method of managing cervicomediastinal tracheal strictures
Authors: N. Guernelli, R. Vecchi, A. Briccoli, R. B Bragaglia
Journal: Thorax (1978)

<b>Guernelli, N, Vecchi, R, Briccoli, A, and Bragaglia, R B (1978).</b><i>Thorax</i>, <b>33</b>, 508-510. <b>A method of managing cervicomediastinal tracheal strictures.</b> We describe our experience in managing two cases of long tracheal strictures and a method of treating extensive lesions.