tbuckley/cabot-search huggingface dataset:
Changing Features of Anginal Pain After PTCA Suggest a Stenosis on a Different Artery Rather Than Restenosis
Authors: Vincenzo Pasceri, Giuseppe Patti, Attilio Maseri
Journal: Circulation (1997)

Background We recently found that patients who had had two myocardial infarctions in different myocardial regions frequently reported different locations of infarct pain, whereas patients who had had two infarcts at the same site had a similar distribution of pain. The aim of this study was to assess whether a different location of anginal pain may help identify patients with a new stenosis on an artery perfusing another myocardial region as opposed to those with restenosis after coronary angioplasty (PTCA). Methods and Results We studied 38 patients (59±11 years old) who underwent PTCA for single-vessel disease, with recurrence of symptoms requiring repeat coronary angiography during a 3-year follow-up. According to our inclusion criteria, angiography showed either a significant restenosis of the dilated lesion, with no evidence of lesions in the other vessels (n=26), or a new stenosis in either of the other coronary arteries, with no restenosis in the dilated vessel (n=12). Before each procedure, patients reported the location and radiation of anginal pain. There was no relation between location of pain and site of the coronary stenosis. However, none of the patients with restenosis reported a different location of pain after angioplasty, compared with 5 patients with new stenosis (0% versus 42%, P =.002). Radiation of pain involved different areas of the body in 1 patient with restenosis and in 6 with new stenosis (4% versus 50%, P =.002). Overall, location or radiation of pain in a different body area had a specificity of 96% and a sensitivity of 58% in detecting a stenosis on a new artery. Conclusions A different location of anginal pain may distinguish patients with a new coronary stenosis from those with restenosis after PTCA for single-vessel disease. These findings suggest that in individual patients, differences in the location of cardiac pain may be indicative of the occurrence of ischemia in different myocardial regions.
PLASTIC REPAIR OF DEPRESSED FRACTURE OF LOWER ORBITAL RIM
Authors: Ralph H. Goldthwaite
Journal: JAMA (1924)

Fracture of the orbital rim, with formation of a depressed notch, may occur from any hard, concentrated blow on the cheek prominence. The bone gives way at about the suture line of the malar bone with the supramaxilla, and the whole inner half of the malar bone is driven into the supramaxilla, telescoping the antrum. As it is impossible to lift the depressed bone from within or without, these cases have usually been left as they were. With the subsidence of inflammatory reaction, the depression becomes more marked; and in very pronounced cases a repair has been made by means of a fascia lata, rib or tibia transplant being fitted into the defect to form the orbital rim. While some satisfactory results have been obtained in this way, there are many chances of poor results, from improper fit of the graft, infection, extrusion or displacement. It is, moreover, quite an
Are "America's Best Hospitals" America's best?
Authors: P. G. Goldschmidt
Journal: JAMA (1997)

<h3>In Reply.</h3> —"America's Best Hospitals" is a peer standard for medical care evaluation, since it implies that hospitals can be judged remotely with no direct knowledge of the care provided. If a Patientwakesup with chest pain and a potential heart attack, he or she may want to select the hospital that is fastest at starting thrombolytic (or other appropriate) therapy. There are no data like that in<i>US News &amp;World</i>Report (or anywhere else). Dr Hartz and colleagues tried to gauge the cardiology rankings from "America's Best Hospitals" against CABG mortality rates from New York and Pennsylvania. This is a useful exercise because there has been no external validation of<i>US News &amp;World Report'</i>s rankings. Unfortunately these CABG mortality rates are themselves seriously flawed.<sup>1</sup> Dr Hill and Mr Comarow, the developer and publisher of "America's Best Hospitals," respectively, have no mandate that compels them "to forge ahead" regardless of the
Spinal ankylosing spondylitis: a variant form of ankylosing spondylitis or a distinct disease entity?
Authors: J T Gran, G Husby, M Hordvik
Journal: Annals of the Rheumatic Diseases (1985)

In a population survey of ankylosing spondylitis (AS) seven subjects, six males and one female, had x-ray changes in the lumbar spine typical of AS but without concomitant roentgenological sacroiliitis. The overall prevalence of such cases in the population studied was 0.37%. Four out of these seven subjects carried the tissue antigen HLA-B27 (57%). The clinical and roentgenological features of these subjects are described and it is suggested that the x-ray findings represent a mild and variant form of primary or definite AS.
Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
Authors: Sven G. Gehrke, Hasan Kulaksiz, Thomas Herrmann, Hans-Dieter Riedel, Karin Bents, Claudia Veltkamp, Wolfgang Stremmel
Journal: Blood (2003)
Addiction to Pentazocine: Report of Two Cases
Authors: William F. Weber
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Reports suggesting low or no addictive potential for pentazocine (Talwin) have appeared in the literature since 1964.<sup>1-4</sup>The drug has been available for unrestricted clinical use since August 1967 and a preparation to be administered orally has been released recently. Clinical experience, although limited, suggests that tolerance develops more slowly to pentazocine than to the narcotics. <h3>Report of Cases.—Case 1.—</h3> A 61-year-old physician complained of recurrent bouts of anxiety and depression for many years. He had attempted to control his symptoms by the use of various drugs, which included stimulants, narcotics, sedatives, tranquilizers, and alcohol. Previously he had not had characteristic features of addiction. Fifteen months prior to his hospital admission, he self-administered his first dose of pentazocine, as treatment for fatigue and "the aching of an old man." He experienced a mild euphoria, but noted a significant degree of relief from irritability, fatigue,
Modern Concepts of the Pathogenesis of Coronary Atherosclerosis.
Authors: C. Bruce Taylor
Journal: JAMA (1963)

In this short, well-written monograph the author approaches coronary atherosclerosis with considerable knowledge and firsthand experience.  The discussion on local factors, which incorporates much of the author's own work, is superbly done and beautifully illustrated in both black and white and color. His original work is also evident in the chapter on intimal lesions. He lucidly describes a technique whereby the intima is stripped from its vessel and mounted as a flat preparation. Microscopy of these flat, stained intimal samples is carried out from the intimal surface. His findings in human vessels corroborate those of Lautsch, McMillan, and Duff in rabbits, and of the reviewer in rabbits and monkeys.  Advantages of tissue cultures of intima are mentioned. The author's findings strongly support earlier concepts that endothelium is different from the primitive mesenchymal cell in the subendothelium. The mesenchymal cell can apparently differentiate into a fibroblast, a lipid-laden macrophage (in the
Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects.
Authors: J E Gern, W Calhoun, C Swenson, G Shen, W W Busse
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Rhinovirus (RV) infections are important triggers of acute asthma symptoms in susceptible persons. To determine whether the presence of allergy is a risk factor for enhanced lower airway effects during RV infection, we experimentally infected (RV16) 18 volunteers with allergic rhinitis and 13 normal control subjects and measured the effects on the response of the lower airways to histamine. All subjects were successfully infected, as indicated by increased upper respiratory symptoms and RV16 cultured from nasal secretions. The change in histamine PD20(deltaPD20) caused by RV infection was significantly different in allergic subjects from that in nonallergic control subjects (deltaPD20 = -0.40 versus -0.03 log units, p = 0.04). This relationship was strengthened after adjusting for initial PD20 and FEV1 (mean deltaPD20 = -0.43 versus 0.01 log units, p < 0.01). The virus-induced deltaPD20 was also influenced by baseline lung function: there was a positive correlation between initial FEV1 and deltaPD20, and a weak but significant negative correlation between baseline PD20 and deltaPD20. These findings indicate that host factors such as allergy, baseline FEV1, and baseline PD20 influence the changes in lower airway physiology caused by RV infection and raise the possibility that these factors contribute to the increased lower airway effects of RV infection in subjects with asthma.
Pneumococcal Meningitis in Sickle-Cell Anemia
Authors: Margaret G. Robinson, R. Janet Watson
Journal: New England Journal of Medicine (1966)

THE association of salmonella osteomyelitis with sickle-cell anemia is well known,1 but that of pneumococcal meningitis with sickle-cell anemia has not been reported. In a recent survey of 305 patients with sickle-cell anemia, hemoglobin C-S and hemoglobin-S-thalassemia disease we have noted that in 87 per cent of patients with proved bacterial meningitis and sickle-cell anemia, the pneumococcus is the responsible organism even in an age group when it is not the most common etiologic agent. There are only 2 reports in the English literature in which meningitis in patients with hemoglobin S is described. Greer and Schotland2 mention 5 cases . . .
THE QUALITY OF PUBLIC WATER SUPPLIES.
Authors: WILLIAM S. JOHNSON
Journal: JAMA (1907)

It is particularly gratifying to me to be called on to speak before a gathering of physicians, as it gives an excellent opportunity to air certain grievances which, as a sanitary engineer, I have against the physician. One of the chief of these grievances is that there is often so little apparent relation between the quality of a water supply and the health of those habitually using the water. Engineering is supposed to be an exact science, and when the cause is present the engineer looks at once for the effect. It grieves him, therefore, when a water supply is obviously polluted, when it is known to contain excreta from typhoid fever patients, that the epidemic of typhoid fever does not follow. On the other hand, he is even more annoyed when, after he has introduced an unpolluted water supply, the high typhoid fever death rate which obtained when the
Aortic Valve Replacement With the Freestyle Stentless Bioprosthesis : Five-Year Experience
Authors: K. L. Yun, C. F. Sintek, A. D. Fletcher, T. A. Pfeffer, G. S. Kochamba, M. R. Hyde, J. O. Torpoco, S. Khonsari
Journal: Circulation (1999)

Stentless aortic valves were designed to provide a more physiological flow pattern and lower transvalvular gradient, which may have an important bearing on postoperative left ventricular function and remodeling. In this study, we prospectively analyzed the 5-year clinical results with the Freestyle valve (Medtronic, Inc) and its hemodynamic performance by serial echocardiography.Between January 1993 and August 1997, 95 patients with a mean age of 75 years underwent aortic valve replacement with the Freestyle prosthesis. Sixty-four percent of patients received valves </=23 mm, and 37% had concomitant coronary artery bypass grafting. Average follow-up was 44+/-18 months (mean+/-SD), and echocardiography was performed preoperatively, at discharge, at 3 to 6 months, and annually thereafter. The 30-day operative mortality rate was 3%, with an overall actuarial survival rate of 80+/-6% (mean+/-SEM) at 5 years. Of the 10 late deaths, only 2 were cardiac related, thereby yielding a freedom from cardiac mortality of 94+/-3% after 5 years. No patient required reoperation on the aortic valve for any reason, including structural degeneration, nonstructural dysfunction, or prosthetic valve endocarditis. There were 9 thromboembolic and 3 anticoagulant-related bleeding events, none of which was fatal. The actuarial freedom from valve-related morbidity and mortality was 79+/-4% at 5 years. Hemodynamically, the mean transvalvular gradient significantly decreased after valve replacement and was reduced further by 41% by 6 months with a corresponding increase in effective orifice area. Left ventricular mass index fell to 75% of the preoperative value by 2 years.The Freestyle stentless valve can be implanted safely in the elderly with excellent midterm clinical results. It has superb hemodynamics in terms of residual transvalvular gradient, effective orifice area, and regression of left ventricular hypertrophy.
Cigarette Smoking and the Acquired Immunodeficiency Syndrome
Authors: LAWRENCE R. BERGER
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 April 1988Cigarette Smoking and the Acquired Immunodeficiency SyndromeLAWRENCE R. BERGER, M.D.LAWRENCE R. BERGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-638_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Cigarette smoking has not, to my knowledge, been scrutinized as a potential risk factor in the acquired immunodeficiency syndrome (AIDS). Various epidemiologic, animal, and in-vitro studies have shown that cigarette smoking can alter the immune response (1-5). Persons positive for the human immunodeficiency virus (HIV) may have an increased risk of manifesting AIDS-related conditions if they are smokers. The appearance of pneumocystis pneumonia, for example, may represent impaired local defenses in the lung as well as impaired systemic immune function.I have been unable to find smoking prevalence data by sexual preference of respondents. However, it is...References1. Effect of cigarette smoking on inflammatory and immune processes in the lung. In: The Health Consequences of Smoking: Chronic Obstructive Lung Disease: A Report to the Surgeon General. Washington, D.C: Department of Health and Human Services, 1974; DHHS publication no. (PHS) 84-50205. Google Scholar2. WARRMARTIN GR. Immune receptors of human alveolar macrophages: comparison between cigarette smokers and nonsmokers. J Reticuloendothelial Soc. 1977;22:181-7. MedlineGoogle Scholar3. THOMASHOLTKEAST WPD. Effect of cigarette smoking on primary and secondary humoral responses of mice. Nature. 1973;243:240-1. CrossrefMedlineGoogle Scholar4. DANIELEDAUBERALTOSE RJM. Lymphocyte studies in asymptomatic cigarette smokers. Am Rev Respir Dis. 1977; 116:997-1005. MedlineGoogle Scholar5. FINKLEAHASSELBLADRIGGAN JVW. Cigarette smoking and hemagglutination inhibition response to influenza after natural disease and immunization. Am Rev Respir Dis. 1971;104:368-76. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lovelace Medical Foundation Albuquerque, NM 87108 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTabacTobaccoCutaneous manifestations and consequences of smokingGrundlagen immunologischer Vorgänge beim Plattenepithelkarzinom im Kopf-Hals-Bereich — Diagnostik und UrsachenBehavioral, health and psychosocial factors and risk for HIV infection among sexually active homosexual men: the Multicenter AIDS Cohort Study. 1 April 1988Volume 108, Issue 4Page: 638-638KeywordsAIDSEpidemiologyHIVImmune responseLungsMedical risk factorsPneumocystisPneumonia Issue Published: 1 April 1988 PDF DownloadLoading ...
PATHOLOGY OF MALIGNANT DISEASES OF NON-EPITHELIAL FORMATION
Authors: F. B. MALLORY
Journal: JAMA (1910)

There are some fourteen different types of simple tumors. Each is due to the proliferation of one variety of cell. The epithelial tumors form the largest group of the simple tumors and their pathology has already been presented to you. The remaining tumors are often called the connective tissue tumors because many of them are of mesenchymal origin. The broader and better term to designate them when placed in contrast with the epithelial tumors is the non-epithelial tumors. It remains for me to present to you as dermatologists certain points of interest concerning the pathology of this large variety of tumors, some of which you see frequently, others rarely or not at all.  CLASSIFICATION AND TYPE OF CELL  A word first in regard to the classification of tumors. Under every recognized variety of tumor should be grouped both the slowly and the rapidly growing tumors built up by the multiplication
Clinical Trial of Methoserpidine in General Practice
Authors: D. L. B. H. Jones, A. M. Michael, J. P. Ommer
Journal: BMJ (1961)

ANAEMIA BRITISC Othe results of a previous survey in an industrial com- munity, the Rhondda Fach.In comparable age-groups the mean values for haemoglobin, P.C.V., and M.C.H.C. were significantly lower in Wensleydale than in the Rhondda.In Wensleydale the prevalence of anaemia in males aged 15-24 was 3.4%, falling to zero in those aged 25-34 and then rising in later decades to 25% in the one 75 years and over.In females of 15-24 years the prevalence of anaemia was 28 %.This figure fell to 12%,/ in age-group 55-64 years and subsequently rose to 21% in the later age-groups.Most of the anaemia was of the iron-deficiency type.Many people contributed to the success of this survey, which was carried out during the tenure of a Cardiff Royal Infirmary Research Fellowship in Medicine.It is a pleasure to acknowledge my indebtedness in particular to Dr.
LOCALIZED ACNEIFORM ERUPTION FOLLOWING COBALT IRRADIATION
Authors: KENNETH M. STEIN, JAMES J. LEYDEN, HERBERT GOLDSCHMIDT
Journal: British Journal of Dermatology (1972)

Journal Article LOCALIZED ACNEIFORM ERUPTION FOLLOWING COBALT IRRADIATION Get access KENNETH M. STEIN, KENNETH M. STEIN Department of Dermatology, Hospital of the University of Pennsylvania, School of Medicine, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, U.S.A Search for other works by this author on: Oxford Academic Google Scholar JAMES J. LEYDEN, JAMES J. LEYDEN Department of Dermatology, Hospital of the University of Pennsylvania, School of Medicine, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, U.S.A Search for other works by this author on: Oxford Academic Google Scholar HERBERT GOLDSCHMIDT HERBERT GOLDSCHMIDT Department of Dermatology, Hospital of the University of Pennsylvania, School of Medicine, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 3, 1 September 1972, Pages 274–279, https://doi.org/10.1111/j.1365-2133.1972.tb00318.x Published: 01 September 1972 Article history Accepted: 14 March 1972 Published: 01 September 1972
Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells
Authors: Isabelle C. Arnold, Nina Dehzad, Sebastian Reuter, Helen Martin, Burkhard Becher, Christian Taube, Anne Müller
Journal: Journal of Clinical Investigation (2011)

Atopic asthma is a chronic disease of the airways that has taken on epidemic proportions in the industrialized world. The increase in asthma rates has been linked epidemiologically to the rapid disappearance of Helicobacter pylori, a bacterial pathogen that persistently colonizes the human stomach, from Western societies. In this study, we have utilized mouse models of allergic airway disease induced by ovalbumin or house dust mite allergen to experimentally examine a possible inverse correlation between H. pylori and asthma. H. pylori infection efficiently protected mice from airway hyperresponsiveness, tissue inflammation, and goblet cell metaplasia, which are hallmarks of asthma, and prevented allergen-induced pulmonary and bronchoalveolar infiltration with eosinophils, Th2 cells, and Th17 cells. Protection against asthma was most robust in mice infected neonatally and was abrogated by antibiotic eradication of H. pylori. Asthma protection was further associated with impaired maturation of lung-infiltrating dendritic cells and the accumulation of highly suppressive Tregs in the lungs. Systemic Treg depletion abolished asthma protection; conversely, the adoptive transfer of purified Treg populations was sufficient to transfer protection from infected donor mice to uninfected recipients. Our results thus provide experimental evidence for a beneficial effect of H. pylori colonization on the development of allergen-induced asthma.
Issues arising from lobby of UN to outlaw circumcision
Authors: George Hill, John V Geisheker
Journal: BMJ (2005)

A theme issue by, for, and about Africa Results from Ugandan programme preventing maternal transmission of HIVEditor-Since the efficacy of antiretroviral drugs in preventing HIV transmission from mother to child was first shown, much effort has been devoted in many countries in Africa to implement sustainable regimens. [1]2][3][4] To identify potential reasons affecting uptake we evaluated the five year performance of a programme at St Francis Hospital Nsambya in Kampala, Uganda.The programme included voluntary counselling and confidential HIV testing for pregnant women and administration of antiretroviral prophylaxis in the peripartum period (zidovudine or nevirapine) for HIV positive women.Overall 24 133 women received counselling, 76% (18 384) agreed to be tested, and 2011 (10.9%) were HIV positive; 1341 (66.7% of the HIV positive women) were enrolled in the programme and received antiretroviral drugs.Acceptance of the test increased from 72.7% (9103/12 524) in 2000-2 to 79.9% (9281/11 609) in 2003-4, when a drug access programme became available in the hospital.Acceptance of the test and enrolment in the programme were lower in married or cohabitating women (test acceptance rate 72.9% (7735/10 605)) than single women (78% (860/1106)), indicating that the fear of being identified as HIV positive in the family is still a strong limiting factor and that men could have an important role.Acceptance of the test was lower in women belonging to the local tribe in Kampala (Baganda), probably because of fear of being recognised by hospital health workers.Higher education was associated with a lower prevalence of HIV and a higher enrolment in the programme, confirming that education can have a key role not only in protecting against HIV but also in allowing HIV positive people to benefit from existing measures against the spread of HIV.
Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study
Authors: Karsten Witt, Christine Daniels, Julia Reiff, Paul Krack, Jens Volkmann, Markus O Pinsker, Martin Krause, Volker Tronnier, Manja Kloss, Alfons Schnitzler, Lars Wojtecki, Kai Bötzel, Adrian Danek, Rüdiger Hilker, Volker Sturm, Andreas Kupsch, Elfriede Karner, Günther Deuschl
Journal: The Lancet Neurology (2008)
Access to specialist palliative care
Authors: A M Smith, A Eve
Journal: BMJ (1994)

EDITOR, - In his review of David Clark's book The Future for Palliative Care, Geoffrey Hanks writes that roughly 15% of the 160 000 patients who die of cancer each year in Britain have access to specialist palliative care.1 This is by no means the full picture.

The hospice information service conducts an annual survey of the palliative care services of Great Britain and the Republic of …