Prostaglandins: Therapy for Peptic Ulcer?
Authors: DONALD E. WILSON
Journal: Annals of Internal Medicine (1973)

Editorials1 August 1973Prostaglandins: Therapy for Peptic Ulcer?DONALD E. WILSON, M.D.DONALD E. WILSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-2-269 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSome of the actions of prostaglandins were first described more than 40 years ago (1); the term "prostaglandin" was coined by von Euler more than 30 years ago (2). These compounds are biologically active, cyclic fatty acids that are ubiquitous in most animal tissues. A recent resurgence of interest in these compounds, no doubt largely because of the discovery and definition of the "second messenger," cyclic adenosine 3′,5′-monophosphate (cyclic AMP), has resulted in a great many reports, published throughout the world, about the chemistry and actions of prostaglandins. Within the past 6 years the gastric antisecretory effects of several of...References1. KURZROKLIEB RC: Biochemical studies of human semen. II. Action of semen on the human uterus. Proc Soc Exp Biol Med 28:268-272, 1930 CrossrefGoogle Scholar2. VON EULER U: A depressor substance in the vesicular gland. J Physiol (Lond) 84:21P-22P, 1935 Google Scholar3. WAYDURBIN LR: Inhibition of gastric acid secretion in vitro by prostaglandin E1. Nature (Lond) 221:874-875, 1969 CrossrefMedlineGoogle Scholar4. ROBERTNEZAMISPHILLIPS AJJ: Inhibition of gastric secretion by prostaglandins. Am J Dig Dis 12:1073-1076, 1967 CrossrefMedlineGoogle Scholar5. RAMWELLSHAW PJ: Prostaglandin inhibition of gastric secretion. J Physiol (Lond) 195:34P-36P, 1968 Google Scholar6. CLASSENKOCHDEYHLE MHP: Wirkung von Prostaglandin E 1 auf die basale Magensekretion des Menschen. Klin Wochenschr 48:876-878, 1970 CrossrefMedlineGoogle Scholar7. WILSONPHILLIPSLEVINE DCR: Inhibition of gastric secretion in man by prostaglandin A1. Gastroenterology 61: 201-206, 1971 CrossrefMedlineGoogle Scholar8. Prostaglandins proposed for ulcer therapy. JAMA 207:481, 1969 Google Scholar9. HORTONMAINTHOMPSON DIC: Effects of orally administered prostaglandin E1 on gastric secretion and gastrointestinal motility in man. Gut 9:655-658, 1968 CrossrefMedlineGoogle Scholar10. LIPPMANN W: Inhibition of gastric acid secretion by a potent synthetic prostaglandin. J Pharm Pharmacol 22:65-67, 1970 CrossrefMedlineGoogle Scholar11. KARIMCARTERBHANA SDD: Effect of orally administered prostaglandin E2 and its 15-methyl analogues on gastric secretion. Br Med J 1:143-146, 1973 CrossrefMedlineGoogle Scholar12. ROBERTMAGERLEIN AB: 15-methyl PGE2 and 16,16-dimethyl PGE2: potent inhibitors of gastric secretion, in International Symposium of Prostaglandins. Advances in Biosciences. Elmsford, N.Y., Pergamon Press, Inc., 1973 Google Scholar13. JACOBSON E: Comparison of prostaglandin E1 and norepinephrine on the gastric mucosal circulation. Proc Soc Exp Biol Med 133:516-519, 1970 CrossrefMedlineGoogle Scholar14. WILSONLEVINE DR: The effect of prostaglandin E1 on canine gastric acid secretion and gastric mucosal blood flow. Am J Dig Dis 17:527-532, 1972 CrossrefMedlineGoogle Scholar15. HARRISALONSO JD: Stimulation of the gastric mucosa by adenosine 3′, 5′-monophosphate. Fed Proc 24:1368-1376, 1965 MedlineGoogle Scholar16. MAOSHANBOURHODGINS CLD: Adenosine 3′, 5′-monophosphate (cyclic AMP) and secretion in the canine stomach. Gastroenterology 63:427-438, 1972 CrossrefMedlineGoogle Scholar17. LEVINEWILSON RD: The role of cyclic AMP in gastric secretion. Ann NY Acad Sci 185:363-375, 1971 CrossrefMedlineGoogle Scholar18. TAFTSESSIONS RJ: Inhibition of gastric acid secretion by dibutyryl cyclic adenosine 3′, 5′-monophosphate (Db.cAMP) (abstract). Clin Res 20:43, 1972 Google Scholar19. ENGELSCRUGGSWILSON JWD: Failure of a prostaglandin inhibitor (SC-19220) to affect prostaglandin E1 (PGE1) gastric antisecretory actions (abstract). Clin Res 21:511, 1973 Google Scholar20. LEECHENGBIANCHI YWR: Effects of oral administration of PGE2 on gastric secretion and experimental peptic ulcerations. Prostaglandins 3:29-45, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCyclic Nucleotides and their Role in Gastrointestinal Secretion 1 August 1973Volume 79, Issue 2Page: 269-270KeywordsAdenosineAdenosine monophosphateFatty acidsPeptic ulcersProstaglandins Issue Published: 1 August 1973 PDF DownloadLoading ...