tbuckley/cabot-search huggingface dataset:
Abstract 3463: Identification and characterization of novel cancer cell derived factors that dictate vascular endothelial cell biology
Authors: Tony Walshe, Justin J. Bourdelais, Arleide Lee, Rakib Ouro-Djobo, Vivek Vishnudas, Michael Kiebish, Rangaprasad Sarangarajan, Niven R. Narain
Journal: Cancer Research (2014)

Abstract Cell-cell communication in the tumor microenvironment drives tumor growth and facilitates neovessel recruitment from the adjacent vasculature. The aim of these experiments were to identify novel cancer derived factors that modulate the vascular endothelial response in a paracrine manner. An array of cancer cell lines from multiple tissue types (Panc1; Hep2G; LnCap; Skmel; Hep3B; PL45; SCC25; CaCo2; PaCa2; SKBR3) were grown under normoxic or hypoxic (1% oxygen) conditions for a total of 20 conditions. After 48 hours, conditioned media was collected and filtered prior to testing on endothelial cells. The effects of these media on endothelial apoptosis, proliferation and tube formation were investigated. In tandem with these endothelial cell fate assays, the proteomic and lipidomic profile of these 20 conditions were profiled and assessed using the Berg Interrogative Biology™ platform. Our results reveal that conditioned media from all cancer cells tested can alter endothelial cell apoptosis, proliferation rate and tube formation in 3D matrigel assays i.e. critical cell fate decisions that enable formation of nascent vessel formation. Interestingly, the predominant effect of tumor-derived conditioned media on endothelial apoptosis was a protective anti-apoptotic effect, with the discernable exception of normoxic Panc1 derived media. An unexpected finding was the general anti-proliferative effects of tumor-derived conditioned media on endothelial cell growth, with the exception of Hep2G, LnCap and PaCa2 cell derived media. Using a media fractionation strategy and the Berg Interrogative Biology™ platform, we identified several endothelial anti-apoptotic candidates from Panc1 cells within a unique molecular weight range. Upon application of ASO gene knockdown in Panc1 cells, these targets were verified for apoptotic and proliferation effects on vascular endothelial cells.Specific factors that determine paracrine cell-cell interaction in the tumor microenvironment have been identified and validated using the Berg Interrogative Biology™ platform. Citation Format: Tony Walshe, Justin J. Bourdelais, Arleide Lee, Rakib Ouro-Djobo, Vivek Vishnudas, Michael Kiebish, Rangaprasad Sarangarajan, Niven R. Narain. Identification and characterization of novel cancer cell derived factors that dictate vascular endothelial cell biology. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3463. doi:10.1158/1538-7445.AM2014-3463
New gonorrhoea strains are resistant to antibiotics
Authors: Caroline White
Journal: BMJ (2006)

The number of strains of gonorrhoea that are resistant to antibiotics has continued to increase in England and Wales, despite recommended changes to first line treatment. Gonorrhoea is the second most commonly transmitted bacterial sexual infection in the United Kingdom.

Figures released by the Health Protection Agency last week indicate considerable regional variations in levels of resistance and sharp increases in resistance among gay men and men who had sexual contact while abroad.

The report was based on results of tests on more than 1600 isolates—mostly from specimens from genitourinary medicine clinics—collected over three months in 2005 in England …
Globin Genes Are Present in Ciona intestinalis
Authors: B. Ebner
Journal: Molecular Biology and Evolution (2003)

The key position of the Ciona intestinalis basal to the vertebrate phylogenetic tree brings up the question of which respiratory proteins are used by the tunicate to facilitate oxygen transport and storage. The publication of the Ciona draft genome sequence suggests that globin genes are completely missing and that—like some molluscs and arthropods—the sea squirt uses hemocyanin instead of hemoglobin for respiration. However, we report here the presence and expression of at least four distinct globin gene/protein sequences in Ciona. This finding is in agreement with the ancestral phylogeny of the vertebrate globins. Moreover, it seems likely that the Ciona hemocyanin-like sequences have enzymatic instead of respiratory functions.
Variation in Aptitude of Trainees in Endoscopic Ultrasonography, Based on Cumulative Sum Analysis
Authors: Sachin Wani, Matthew Hall, Rajesh N. Keswani, Harry R. Aslanian, Brenna Casey, Rebecca Burbridge, Amitabh Chak, Ann M. Chen, Gregory Cote, Steven A. Edmundowicz, Ashley L. Faulx, Thomas G. Hollander, Linda S. Lee, Daniel Mullady, Faris Murad, V. Raman Muthusamy, Patrick R. Pfau, James M. Scheiman, Jeffrey Tokar, Mihir S. Wagh, Rabindra Watson, Dayna Early
Journal: Clinical Gastroenterology and Hepatology (2014)
Effects of sputum on pulmonary function.
Authors: G M Cochrane, B A Webber, S W Clarke
Journal: BMJ (1977)

<h3>Introduction</h3> COVID-19, caused by the SARS-CoV-2, has been one of the most highly contagious and rapidly spreading virus outbreak. The pandemic not only has catastrophic impacts on physical health and economy around the world, but also the psychological well-being of individuals, communities and society. The psychological and social impacts of the COVID-19 pandemic internationally have not been well described. There is a lack of international study assessing health-related impacts of the COVID-19 pandemic, especially on the degree to which individuals are fearful of the pandemic. Therefore, this study aims to (1) assess the health-related impact of the COVID-19 pandemic in community-dwelling individuals around the world; (2) determine the extent various communities are fearful of COVID-19 and (3) identify perceived needs of the population to prepare for potential future pandemics. <h3>Methods and analysis</h3> This global study involves 30 countries. For each country, we target at least 500 subjects aged 18 years or above. The questionnaires will be available online and in local languages. The questionnaires include assessment of the health impacts of COVID-19, perceived importance of future preparation for the pandemic, fear, lifestyles, sociodemographics, COVID-19-related knowledge, e-health literacy, out-of-control scale and the Patient Health Questionnaire-4. Descriptive statistics will be used to describe participants' characteristics, perceptions on the health-related impacts of COVID-19, fear, anxiety and depression, lifestyles, COVID-19 knowledge, e-health literacy and other measures. Univariable and multivariable regression models will be used to assess the associations of covariates on the outcomes. <h3>Ethics and dissemination</h3> The study has been reviewed and approved by the local ethics committees in participating countries, where local ethics approval is needed. The results will be actively disseminated. This study aims to map an international perspective and comparison for future preparation in a pandemic.
Normal neuropsychological development in children with congenital complete heart block who may or may not be exposed to high-dose dexamethasone in utero
Authors: A Brucato, M G Astori, R Cimaz, P Villa, M Li Destri, L Chimini, R Vaccari, M Muscara, M Motta, A Tincani, F Neri, S Martinelli
Journal: Annals of the Rheumatic Diseases (2006)

Antenatal and postnatal treatment with dexamethasone (DEX) may negatively affect the neuropsychological development in children. Maternal anti-Ro/Sjögren's syndrome A (SSA) antibodies may also be associated with learning disabilities in offspring.To assess neuropsychological development in babies exposed to very high dosages of DEX in utero, whose mothers were anti-Ro/SSA positive.13 children with congenital complete heart block (CHB) (11 exposed and 2 not exposed to DEX) and 3 healthy siblings, all of anti-Ro/SSA-positive women, were evaluated. 11 preschool-aged children (5 boys) were assessed using Griffiths Mental Development Scales. 5 school-aged children (2 boys) were examined using Wechsler Intelligence Scale for Children-Revised to check IQ and reading tests to explore the existence of learning disabilities or dyslexia. None of the children had had major neonatal complications, although those with CHB had to be paced at different intervals from birth.The children had been exposed in utero to a mean total dose of 186.6 mg DEX. IQ levels were always normal (mean IQ 105.1, standard deviation (SD) 9.5). Only one child had a learning disability, of borderline clinical significance, but this child had never been exposed to DEX.No negative effects were found on the neuropsychological development in this cohort of children, even if they had been exposed to maternal anti-Ro/SSA antibodies and to very high dosages of DEX (much higher than those used to improve fetal lung maturity). These findings might be of interest in view of the large number of infants exposed in the past to repeated antenatal courses of steroids.
1079-101 Therapeutic strategies and outcomes in patients with previous coronary artery bypass graft following a new acute coronary syndrome: Insights from the GRACE experience
Authors: Viviana Brito, Ricardo Perez de la Hoz, Edgado Sampó, Ernesto Duronto, Omar H Dabbous, Neelam Gowda, Enrique P Gurfinkel
Journal: Journal of the American College of Cardiology (2004)
Relation between sampling device and detection of abnormality in cervical smears: a meta-analysis of randomised and quasi-randomised studies
Authors: F. Buntinx, M. Brouwers
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To assess the diagnostic yield of different sampling devices used in cervical screening. <b>Design</b>: Meta-analysis of randomised and quasi-randomised studies. <b>Setting</b>: All randomised and quasi-randomised studies comparing the yield of cytological or histological abnormalities when two or more different sampling devices were used. <b>Subjects</b>: 85 000 patients included in 29 studies reported in 28 papers. <b>Main outcome measures</b>: Pooled relative risk and 95% confidence interval of the yield of mild dysplasia or worse in smears recovered by each sampling method versus each other method with which it was compared; sensitivity or positive predictive value, or both, of cytological versus histological results in six studies from which sufficient data were available. <b>Results</b>: There were no substantial differences in the yield of cytological abnormalities between the Ayre spatula, the Cytobrush, and the cotton swab used alone. There were also no substantial differences in the yield of cytological abnormalities between the extended tip spatula, the Ayre spatula combined with the Cytobrush or cotton swab, or the Cervex brush. The Ayre spatula, Cytobrush, or cotton swab used alone generally performed significantly worse than the combinations, the extended tip spatula, or the Cervex brush. There were no substantial differences in sensitivity or positive predictive value between the sampling methods. <b>Conclusions</b>: These results support the use of either the extended tip spatula, a combination of any spatula plus the Cytobrush or cotton swab, or the Cervex brush for cervical screening. <h3>Key messages</h3> The Ayre spatula, Cytobrush, or cotton swab alone generally performed significantly worse than the combination of a spatula and Cytobrush or cotton swab, the extended tip spatula, or the Cervex brush No substantial differences in sensitivity or positive predictive value were detected between the sampling methods Results support the use of either the extended tip spatula, the combination of any spatula plus Cytobrush or cotton swab, or the Cervex brush for cervical screening
Medical support of troops in Bosnia includes screening for problems when homeward bound
Authors: P. Gunby
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful endoscopic submucosal dissection of duodenal cancer
Authors: S. Yoshida, M. Shimada, T. Ueno, Y. Kitamura, S. Matsuzaki, S. Nishikubo, M. Nagae, K. Nakanishi, J. Murata, M. Yoshino
Journal: Endoscopy (2008)

This is the first report of complete resection of early duodenal cancer using endoscopic submucosal dissection (ESD) monotherapy.
Chlorpromazine for Treatment of Underweight
Authors: Frederick Lemere
Journal: JAMA (1969)

ABSTRACT To the Editor:— The response to the question regarding management of the underweight woman which appeared in The Journal (209:2061, 1969) suggested insulin injections and large doses of chlorpromazine but only for inpatients. For outpatients, the only suggestion was reassurance that underweight was healthy and cosmetically advantageous. I would doubt that severe underweight is cosmetically acceptable to most people. At any rate, many patients who wish to gain weight can often achieve this through the use of chlorpromazine on an office or outpatient basis. One of the side effects, often undesirable, of the psychiatric use of phenothiazines, especially chlorpromazine, is a marked gain in weight. Weight gain can be controlled by the dosage which should be to the point of comfortable tolerance, such as 75 to 150 mg daily. On this regimen, if followed for two or three months, weight gain can usually be achieved, although it often seems
LECTIN-LIKE OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR-1 (LOX-1) MAY BE INVOLVED IN SMOKING-INDUCED INFLAMMATION AT VESSEL WALLS
Authors: Rieko Takanabe-Mori, Koh Ono, Hiromichi Wada, Tomohide Takaya, Hajime Yamakage, Noriko Satoh-Asahara, Akira Shimatsu, Yuko Takahashi, Masatoshi Fujita, Yoshiko Fujita, Tatsuya Sawamura, Koji Hasegawa
Journal: Journal of the American College of Cardiology (2012)
The Treatment of Gonococcal Proctitis
Authors: Nicholas J. Fiumara
Journal: JAMA (1978)

A group of 1,533 homosexual males were examined in 1976 for gonorrhea at the Skin Clinic of the Boston Dispensary. This examination included a rectal culture. There were 213 males with positive rectal cultures: an infection rate of 13.7%. Of these, 173 were treated with 4 g of spectinomycin hydrochloride, intramuscularly, and 127 (73.4%) returned in one week for a posttreatment examination and culture. All who returned had a negative culture. Four grams of intramuscular spectinomycin hydrochloride appears to be effective in the treatment of gonococcal proctitis.
Use of the Over-The-Scope Clip for treatment of refractory upper gastrointestinal bleeding: a case series
Authors: Shannon Chan, Philip Chiu, Anthony Teoh, James Lau
Journal: Endoscopy (2014)

The Over-The-Scope Clip (OTSC; Ovesco, Tübingen, Germany) is a novel endoscopic clipping device designed for tissue approximation. The device has been used in the closure of fistulas and perforations. We hereby report on a series of patients in whom OTSCs were used for endoscopic control of refractory or major upper gastrointestinal bleeding from lesions in the gastroduodenal tract between 1 July and 31 December 2012. Nine patients were included (median age 72.5 years, range 39 – 91) with bleeding gastric ulcers (n = 2), bleeding duodenal ulcers (n = 5), bleeding gastrointestinal stromal tumor in the stomach (n = 1), and bleeding from ulcerative carcinoma of the pancreas (n = 1). The median size of the ulcers was 2.5 cm (range 1 – 4). Six of the nine patients had undergone previous endoscopic hemostasis. Technical success was achieved in all patients and the clinical effectiveness was 77.8 %. The OTSC is a safe and effective method of endoscopic hemostasis for major bleeding from miscellaneous upper gastrointestinal causes and should be considered in patients with refractory bleeding after failure of conventional methods of endoscopic hemostasis.
BCL6 breaks occur at different AID sequence motifs in Ig–BCL6 and non-Ig–BCL6 rearrangements
Authors: Zhengfei Lu, Albert G. Tsai, Takashi Akasaka, Hitoshi Ohno, Yanwen Jiang, Ari M. Melnick, Harvey A. Greisman, Michael R. Lieber
Journal: Blood (2013)
Pralatrexate Pharmacology and Clinical Development
Authors: Enrica Marchi, Michael Mangone, Kelly Zullo, Owen A. O'Connor
Journal: Clinical Cancer Research (2013)

Abstract Folates are well known to be essential for many cellular processes, including cellular proliferation. As a consequence, antifolates, the fraudulent mimics of folic acid, have been shown to be potent therapeutic agents in many cancers. Over the past several decades, efforts to improve on this class of drugs have met with little success. Recently, one analog specifically designed to have high affinity for the reduced folate carrier, which efficiently internalizes natural folates and antifolates, has been shown to be very active in T-cell lymphoma. Pralatrexate, approved by the U.S. Food and Drug Administration in 2009, is highly active across many lymphoid malignancies, including chemotherapy-resistant T-cell lymphoma. Emerging combination studies have now shown that pralatrexate is highly synergistic with gemcitabine, histone deacetylase inhibitors like romidepsin and bortezomib. These insights are leading to a number of novel phase I and II combination studies which could challenge existing regimens like CHOP, and improve the outcome of patients with T-cell lymphoma Clin Cancer Res; 19(24); 6657–61. ©2013 AACR.
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Authors: Fernando Rivadeneira, Unnur Styrkarsdottir, Karol Estrada, Bjarni V. Halldorsson, Yi-Hsiang Hsu, J Brent Richards, M. Carola Zillikens, Fotini K. Kavvoura, Najaf Amin, Yurii S. Aulchenko, L Adrienne Cupples, Panagiotis Deloukas, Serkalem Demissie, Elin Grundberg, Albert Hofman, Augustine Kong, David Karasik, Joyce B J van Meurs, Ben A. Oostra, Tomi Pastinen, Huibert A.P. Pols, Gunnar Sigurdsson, Nicole Soranzo, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Frances Mk Williams, Scott G. Wilson, Yanhua Zhou, Stuart H Ralston, Cornelia M. van Duijn, Timothy D. Spector, Douglas P Kiel, Kari Stefansson, John P.A. Ioannidis, André G. Uitterlinden
Journal: Nature Genetics (2009)
Malignancy Rate of Thyroid Nodules Defined as Follicular Lesion of Undetermined Significance and Atypia of Undetermined Significance in Thyroid Cytopathology and Its Relation with Ultrasonographic Features
Authors: Neslihan Çuhaci, Dilek Arpaci, Rıfki Üçler, Aylin Kilic Yazgan, Gülten Kıyak, Samet Yalçin, Pamir Eren Ersoy, Gülnür Güler, Reyhan Ersoy, Bekir Çakir
Journal: Endocrine Pathology (2014)
Detection of crystals in synovial fluids by light microscopy: sensitivity and reliability.
Authors: C Gordon, A Swan, P Dieppe
Journal: Annals of the Rheumatic Diseases (1989)

Polarised light microscopy of synovial fluid is an established diagnostic technique widely regarded as reliable for the detection of crystals. The threshold concentration of crystals which can be detected has been investigated and the sensitivity and specificity of six observers compared. Various concentrations of laboratory manufactured crystals of monosodium urate monohydrate (MSUM), calcium pyrophosphate dihydrate (CPPD), and basic calcium phosphates (BCP) were added to the synovial fluid. The threshold for reliable identification of MSUM and CPPD was in the range of 10-100 micrograms/ml. False positives were frequent. The mean sensitivity of the six observers for MSUM was 69% and for CPPD was 82%. The mean specificity for MSUM was 97% and for CPPD was 78%. There was much discrepancy in the results of the slides stained with alizarin red S. Thus the value of alizarin red S as a screening test for BCP is questioned. In view of the variable sensitivity and specificity of different observers for MSUM and CPPD and the concentration threshold for reliable crystal identification, greater caution in the interpretation of synovial fluid analysis is advised, and recommendations for increased quality control are supported.
High dose nitrogen mustard therapy for bronchial carcinoma.
Authors: J Manns
Journal: Thorax (1969)

ALTOUNYAN There have been considerable advances in recent years in the understanding of the nature of allergic reactions occurring in the lungs and the many ways in which these reactions present in clinical practice.This symposium is aimed at considering the mechanisms and clinical implications of these allergic reactions, with particular reference to their importance in disorders of the bronchi.First, the nature and mechanism of allergic reaction in pulmonary disease are considered.The chemical mediators of some of the responses to these allergic reactions and the effects of administration of specific antagonists to these substances are then reviewed.Recent studies have demonstrated that one of the most important reactions, airways obstruction, cannot be explained simply as broncho-constriction; current views are presented together with their relevance to the limita- tions of spirometric methods of assessing changes in airways obstruction.Finally, practical aspects of the identification of patients in whom an allergic reaction is causing, or is contributing to, their bronchial disorders, and the assessment of its importance in individual patients are considered.
Mid Staffordshire trust is insolvent and clinically unsustainable, finds report
Authors: Z. Kmietowicz
Journal: BMJ (2013)

Independent assessors are considering how Mid Staffordshire Foundation NHS Trust services should be reorganised, including which need to remain local and which could be provided by private companies, after they found that the trust was facing financial and clinical collapse.

Monitor, the economic regulator of the NHS, appointed a contingency planning team last September to look at the long term solutions for providing services to the trust’s patients.

In an interim report on the sustainability of the trust, the team, made up of experts from the consultancy firms Ernst & Young and McKinsey, concluded that standards of care at the trust were acceptable and that it was “operationally sustainable,” meaning that it had the organisational structure, operating model, governance, risk management procedures, and operational …
Determinants of coronary blood flow after thrombolytic administration
Authors: C.Michael Gibson, Sabina Murphy, Ian B.A. Menown, Rafael F. Sequeira, Robert Greene, Frans Van de Werf, Marc J. Schweiger, Magdi Ghali, Martin J. Frey, Kathryn A. Ryan, Susan J. Marble, Robert P. Giugliano, Elliott M. Antman, Christopher P. Cannon, Eugene Braunwald
Journal: Journal of the American College of Cardiology (1999)