tbuckley/cabot-search huggingface dataset:
Copper, Anemia, and Neutropenia
Authors: SEYMOUR HERSCHBERG
Journal: Annals of Internal Medicine (1974)

Comments and Correction1 October 1974Copper, Anemia, and NeutropeniaSEYMOUR HERSCHBERG, M.D.SEYMOUR HERSCHBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-4-568_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Dunlap, James, and Hume (Ann Intern Med80:470-476, 1974) suggests that the rapid reversal of neutropenia before the anemia in the first case may have been caused by a lesser need of granulocytes for copper or differences in cell kinetics, or both. If one accepts these explanations, one then has to seek a different explanation for the second case. The authors postulate that the patient in the second case had neutropenia without anemia because the copper stores were not sufficiently depleted to produce anemia. The explanations postulated for the first case, if correct, would...Reference1. CORDANOPLACKOGRAHAM ARG: Hypocupremia and neutropenia in copper deficiency. Blood 28:280-283, 1966 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Fordham Hospital Bronx, New York 10458 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1974Volume 81, Issue 4Page: 568-568KeywordsAnemiaGranulocytesNeutropenia Issue Published: 1 October 1974 PDF DownloadLoading ...
UNTOWARD RESULTS OF NEPHROLITHOTOMY
Authors: MARTIN KROTOSZYNER
Journal: JAMA (1913)

HISTORY  The first references as regards the practicability of nephrotomy were traced by Henry Morris 1 to the early French medical literature (Camerarius and Roussett in 1581). During the next two centuries the feasibility of renal incision in nephrolithiasis was repeatedly discussed on theoretical grounds by various writers, particularly of the French school (Ducledat and Consinot in 1622, De Lafitte in 1753), but was not put into practical use, probably on account of Hevin's indictment of surgical interference in stone-kidney (1753). The influence of this famous monograph was of such weight as to retard for more than a century any further practical progress, in spite of the strong plea made by several writers of that period in favor of early incision (Gerdy 1829, Rayer 1849).  The feasibility of nephrotomy for the extraction of renal concrements was, toward the end of the nineteenth century, almost simultaneously discussed by several prominent British
Evolution of ADAMTS13 antibodies in a fatal case of thrombotic thrombocytopenic purpura
Authors: Lingli Dong, Visalam Chandrasekaran, Wenhua Zhou, Han‐Mou Tsai
Journal: American Journal of Hematology (2008)

In a patient with fatal thrombotic thrombocytopenic purpura, the inhibitory activity of antibodies against ADAMTS13 rapidly escalated to extremely high levels despite daily plasma exchange and corticosteroid therapy. This increase was found to be because of a combination of higher antibody concentration and potency. Furthermore, during her course of the disease, the percentage of IgG(1) antibody progressively decreased whereas that of IgG(2) antibody increased, suggesting Th1-type cytokine response. These changes suggest that the course of TTP may be exacerbated by complex immune reactions. Further characterization of the factors contributing to this exacerbation may have important pathogenetic and therapeutic implications.
Isoniazid as Preventive Therapy in HIV-Infected Intravenous Drug Abusers
Authors: Theresa J. Jordan
Journal: JAMA (1991)

Tuberculin skin testing is a notoriously poor marker of tuberculosis infection in patients who are serologically positive for the human immunodeficiency virus. A decision analysis was performed to determine if and when isoniazid should be prescribed to prevent tuberculosis in these patients. The decision was analyzed for an intravenous drug abuser who may have been anergic, while tuberculin test status, race, and gender were varied. The assumptions and parameter estimates selected for this investigation represent a highly conservative vantage point opposing the use of isoniazid as a preventive therapy. Nevertheless, results showed a benefit from the use of isoniazid as a preventive therapy for all groups, even without tuberculin testing, except tuberculin-negative black women. This benefit of isoniazid therapy increased patient life expectancy as much as 285 days. Further, the decisions continue to favor prescribing isoniazid even when the suspected incidence of tuberculosis infection falls as low as 3% to 8%. Tuberculin testing appears important primarily for black women, since those who have negative tuberculin skin tests may not be candidates for isoniazid therapy.
COMPARISONS OF EARLY PHASE ARTERIAL REACTION AFTER 2ND GENERATION DRUG-ELUTING AND BARE-METAL STENTS IMPLANTATION IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: 2-WEEK OBSERVATIONS OF OPTICAL COHERENCE TOMOGRAPHY EVALUATION
Authors: Ryo Nishio, Toshiro Shinke, Yoshihiro Morino, Kengo Tanabe, Jungo Furuya, Kaname Takizawa, Junya Ako, Ken Kozuma, Kiyoshi Hibi, Hideki Ishii, Atsushi Hirohata, Yoritaka Otsuka, Hiromasa Otake, Tomofumi Takaya, Ken-ichi Hirata
Journal: Journal of the American College of Cardiology (2014)
Patients with head or neck cancer should be treated at specialist centres
Authors: Madeleine Brettingham
Journal: BMJ (2004)

The National Institute for Clinical Excellence (NICE) has issued guidelines on the treatment of patients with rare cancers of the head and neck. The guidelines, based on research conducted by the Centre for Reviews and Dissemination, advise that treatment should be centred at specialised cancer centres serving populations of over a million, where multidisciplinary teams will be responsible for all stages of the treatment process, including diagnosis and rehabilitation.

Head and neck cancers are not common and encompasses a range of conditions located at some 30 sites around the head and neck. Some, …
How well can radiographers triage x ray films in accident and emergency departments?
Authors: I G Renwick, W P Butt, B Steele
Journal: BMJ (1991)

OBJECTIVE--To assess the ability of radiographers to identify abnormal radiographs of patients attending accident and emergency departments. DESIGN--Prospective study over six weeks. SETTING--Teaching hospital casualty x ray department. PATIENTS--3394 consecutive patients referred for radiography. INTERVENTIONS--Radiographs were assessed by radiographers who were offered a four point triage scheme: normal, abnormal, insignificantly abnormal, or further advice required. MAIN OUTCOME MEASURES--Comparison of radiographers9 assessments with an assessment made independently by the reporting radiologists. RESULTS--Overall disagreement between the radiographers and radiologists was 9.4%. There were 7% false positives and 14% false negatives. Most errors occurred in assessing radiographs of the skull, facial bones, chest, abdomen, and soft tissues. CONCLUSION--Unselected radiographers can offer useful advice on radiographs to casualty officers, but their high rate of false positive diagnoses indicates that they cannot triage casualty radiographs sufficiently accurately to allow them to extend their current reporting role.
Response of the Limb Vascular Bed in Man to Intrabrachial Arterial Infusions of Hypertonic Dextrose or Hypertonic Sodium Chloride Solutions
Authors: HENRY W. OVERBECK, GEORGE J. GREGA
Journal: Circulation Research (1970)

Infusions of hypertonic dextrose or NaCl solutions reduce resistance in several vascular beds of experimental animals. To study the response in man, 60 intrabrachial arterial jet infusions of hypertonic dextrose solution or hypertonic NaCl solution, each at 3 dose levels (1, 2, and 4 milliosmols/min), were made in 19 male student volunteers aged 21 to 29 years. Limb blood flow was measured by continuous infusion indicator-dilution, and vascular resistance calculated as mm Hg/ml flow/100 cm 3 limb vol/min. Measured increases in ipsilateral cephalic venous plasma osmolarity and serum dextrose and sodium concentrations during hypertonic infusions ranged from 7 to 30 milliosmols/liter, 153 to 481 mg/100 ml and 4 to 19 mEq/liter, respectively. Measured limb venous blood hematocrit during hypertonic infusions was similar to that during control isotonic infusions. All 60 hypertonic infusions evoked an increase in limb blood flow and decrease in limb vascular resistance as compared to "resting" values during paired control isotonic NaCl infusions. There was a significant (P&lt;.01) positive linear correlation between level of initial vascular resistance and magnitude of response to all hypertonic infusions. At each dose level, neither regression coefficient nor regression adjusted mean response to dextrose was significantly different from that to hypertonic NaCl (P&gt;.05). The results of these studies indicate that the local vascular response to hypertonicity in the limb of man is a decrease in resistance, the magnitude of which is a function of the level of plasma osmolarity and the level of initial limb resistance. The steady-state responses to hypertonic dextrose are quantitatively similar to those to hypertonic NaCl.
Using the Clinical Laboratory in Medical Decision-Making
Authors: Rex B. Conn
Journal: JAMA (1984)

The responses among the medical readers to this book will be as varied as their reactions to eating escargot. Some must eat and many eschew French cooking, but a dedicated group of enthusiasts believe that properly prepared snails represent the epitome of Gallic cuisine. In a similar manner, all physicians make medical decisions, some have little interest in analysis of the decision-making process, while others believe the process can be improved by thoughtful analysis and application of logical principles. The last group will receive this book with enthusiasm; however, it represents a concise introduction to diagnostic algorithms that would benefit all medical decision makers. This volume is a collection of articles previously published inThe Journalin a series entitled "Toward Optimal Laboratory Use." They have been revised and updated by the original authors and subjected to peer review once again. The introductory chapters deal with basic aspects of clinical
Early diagnosis of cirrhosis with 99m-technetium pertechnetate per-rectal portal scintigraphy (99mTc test)
Authors: A. D'Arienzo, L. Celentano, L. Cimino, A. Panarese, C. Lancia, G.Cannada Bartoli, E. Vergara, G. Squame, G. Budillon, G. Mazzacca
Journal: Journal of Hepatology (1990)
Clarithromycin Attenuates Acute and Chronic Rejection Via Matrix Metalloproteinase Suppression in Murine Cardiac Transplantation
Authors: Masahito Ogawa, Jun-ichi Suzuki, Keiichi Hishikari, Kiyoshi Takayama, Hiroyuki Tanaka, Mitsuaki Isobe
Journal: Journal of the American College of Cardiology (2008)
Surgical treatment of benign endobronchial tumours
Authors: P Halttunen, H Meurala, C-G Standertskjold-Nordenstam
Journal: Thorax (1982)

Four cases of benign endobronchial tumour are reported which were successfully treated by bronchial resection. In two cases (of fibroma and leiomyoma respectively) a cylinder of bronchus alone was resected; in one case (lipoma) a healthy right upper lobe was preserved by a bronchoplastic procedure and in the other (chondroma) the tumour was removed with the right lower lobe, which was irreversibly damaged. It is important to recognise that such tumours are unsuitable for treatment by endoscopic means alone.
Intra-amniotic Transient Transduction of the Periderm With a Viral Vector Encoding TGFβ3 Prevents Cleft Palate in Tgfβ3−/− Mouse Embryos
Authors: Chadwick Wu, Masa Endo, Byung H Yang, Melissa A Radecki, Patrick F Davis, Philip W Zoltick, Ryan M Spivak, Alan W Flake, Richard E Kirschner, Hyun-Duck Nah
Journal: Molecular Therapy (2012)

Cleft palate is a developmental defect resulting from the failure of embryonic palatal shelves to fuse with each other at a critical time. Immediately before and during palatal fusion (E13-E15 in mice), transforming growth factor β3 (TGFβ3) is expressed in the palatal shelf medial edge epithelium (MEE) and plays a pivotal role in palatal fusion. Using Tgfβ3(-/-) mice, which display complete penetrance of the cleft palate phenotype, we tested the hypothesis that intra-amniotic gene transfer could be used to prevent cleft palate formation by restoring palatal midline epithelial function. An adenoviral vector encoding Tgfβ3 was microinjected into the amniotic sacs of mouse embryos at successive developmental stages. Transduced Tgfβ3(-/-) fetuses showed efficient recovery of palatal fusion with mesenchymal confluence following injection at E12.5 (100%), E13.5 (100%), E14.5 (82%), and E15.5 (75%). Viral vectors injected into the amniotic sac transduced the most superficial and transient peridermal cell layer but not underlying basal epithelial cells. TGFβ3 transduction of the peridermdal cell layer was sufficient to induce adhesion, fusion, and disappearance of the palatal shelf MEE in a cell nonautonomous manner. We propose that intra-amniotic gene transfer approaches have therapeutic potential to prevent cleft palate in utero, especially those resulting from palatal midline epithelial dysfunction.
EVALUATION OF THE RADIATION DOSE RECEIVED BY THE MEDICAL TEAM DURING TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Vincent Descotes Genon, Paul Luporsi, Romain Chopard, Sebastien Janin, Kais Mrabet, Sidney Chocron, Nicolas Meneveau, Francois Schiele
Journal: Journal of the American College of Cardiology (2011)
GENDER DIFFERENCES IN ADJUNCTIVE TREATMENT AND HOSPITAL OUTCOME OF NSTE-ACS PATIENTS UNDERGOING PCI IN CLINICAL PRACTICE IN EUROPE: LESSONS FROM THE EURO HEART SURVEY PCI REGISTRY
Authors: Anselm K. Gitt, Timm Bauer, Uwe Zeymer, Ralf Zahn, Franz Weidinger, Ricardo Seabra-Gomes, Jean Marco
Journal: Journal of the American College of Cardiology (2010)
Multistage Electrotherapy Delivered Through Chronically-Implanted Leads Terminates Atrial Fibrillation With Lower Energy Than a Single Biphasic Shock
Authors: Ajit H. Janardhan, Sarah R. Gutbrod, Wenwen Li, Di Lang, Richard B. Schuessler, Igor R. Efimov
Journal: Journal of the American College of Cardiology (2013)
A COMPLEMENT FIXATION TEST FOR POLIOMYELITIS
Authors: Nathalie J. Schmidt, Edwin H. Lennette
Journal: The Journal of Experimental Medicine (1955)

A macroscopic (tube) complement fixation test for poliomyelitis, using infected tissue culture fluids, is described. The test was applied to 27 individuals with a clinical diagnosis of poliomyelitis. In 18 patients it was possible to make a laboratory diagnosis of poliomyelitis on the basis of a rise in complement-fixing antibody titer and in 4 others on the basis of a high stationary antibody titer. One individual gave a high and equal antibody response to two virus types, 3 others had no detectable antibody, and 1 appeared not to have poliomyelitis. Heterotypic reactions were encountered, but gave little difficulty in interpreting homologous responses. In those patients from whom a virus had been recovered, the serologic findings corresponded to the virus type recovered. The possible occurrence of dual infections with the viruses of poliomyelitis and Western equine and St. Louis encephalitis is discussed.
Atopy and childhood recurrent wheezing — An 8 year prospective study
Authors: Mário Morais Almeida, Ângela Gaspar, Sara Prates, Graça Pires, Ana Romeira, Carlos Braga, Teresa Almeida, Graça Sampaio, Céu Teixeira, Elsa Pargana
Journal: Journal of Allergy and Clinical Immunology (2002)
Blast Crisis — Reversing the Direction
Authors: Jane F. Desforges, Kenneth B. Miller
Journal: New England Journal of Medicine (1986)

The course of chronic myelocytic leukemia (CML) has changed little since the initial description by Minot in 1924.1 In the chronic state there is excessive proliferation of myeloid cells without loss of their capacity to differentiate. Neoplastic transformation occurs at the level of the pluripotent stem cell, with involvement of the myeloid, erythroid, megkaryocytic and lymphoid cell lines. Both cytogenetic and isoenzyme studies have provided evidence that CML is a clonal hematopoietic disorder arising from a single cell. The Philadelphia chromosome, the hallmark of CML, has been demonstrated in all hematopoietic precursor cells.2 , 3 It is an abnormal chromosome 22 in . . .
Normal and Pathological Aging of Attention in Presymptomatic Huntington’s, Huntington’s and Alzheimer’s Disease, and Nondemented Elderly Subjects
Authors: Charles-Siegfried Peretti, Florian Ferreri, François Blanchard, Serge Bakchine, Charles Roger Peretti, Andrei Dobrescu, Virginie-Anne Chouinard, Guy Chouinard
Journal: Psychotherapy and Psychosomatics (2008)

Attention models view attention as having at least two components: endogenous attention defined as executive and directed by voluntary acts, and exogenous attention defined as automatic and directed by external stimulation.Three studies (2 of our own) were designed to evaluate the decline of these two components of attention in normal aging and two neurodegenerative diseases. Standardized tests derived from Posner's model of visuospatial attention were administered to normal healthy elderly participants (n = 13), patients suffering from Huntington's disease (HD; n = 17) and Alzheimer's disease (n = 15), and matched control subjects (n = 57). Outcome measures were reaction time (RT) and RT difference score (defined as invalid RT minus valid RT).In healthy elderly participants, the decline was more pronounced for endogenous attention in situations of perceptual conflict. In Alzheimer's disease, there was a significant decline in both attention components, while in HD, voluntary attention was markedly impaired and automatic attention preserved.Normal aging and HD are characterized by decreased endogenous attention in situations of perceptual conflict. Our data support previous findings that older people display impairment of attention in complex perceptual situations. We propose a model which allows for the separation of attention pathologies, thus improving therapeutic strategies for patients and elderly.
Mesh Repair of Inguinal Hernias — Redux
Authors: Danny O. Jacobs
Journal: New England Journal of Medicine (2004)

An abdominal-wall hernia occurs when the abdominal contents protrude through a congenital or acquired defect in the supportive tissues. Although hernias can develop in many locations, including areas weakened by surgical incisions, they are most commonly identified in the groin or around the umbilicus. More than 800,000 hernia operations were performed in the United States in 2003; most of them were performed in men and on an outpatient basis, and most involved the use of mesh prostheses.1 Until the late 1980s, the standard method of inguinal hernia repair was the suturing of various fascial structures bordering the hernia defect. These . . .
Abstract 317: Role of ATM and PTEN in prostatic carcinogenic dog prostate: validation of aCGH results.
Authors: Carlos E. Fonseca Alves, Patricia R. Pellicciari, Marcela M. P. Rodrigues, Silvia R. Rogatto, Renee L. Amorim
Journal: Cancer Research (2013)

Abstract The canis lupus familiares is the only species besides human that spontaneously develop prostatic carcinoma (PCa). In addition, the metastatic sites are similar to those frequently reported in men. For these reasons, the dog is the best natural model to study the molecular mechanisms in PCa development providing a natural animal model for treatment by molecular targets. Previously, we investigated copy number alterations by arrayCGH (Canine Genome CGH Microarray 4x44K-G2519F, Agilent Technologies) in canine prostatic lesions: 3 benign prostatic hyperplasias (BPH), 4 proliferative inflammatory atrophies (PIA), and 14 PCa. Five histologically normal prostatic tissues were used as reference. Genomic alterations were evaluated using Genomic Workbench Standard Edition 5.0.14. This previous study revealed significant copy number losses of Atm and Pten exclusively in PCa. In the present study, ATM and PTEN immunoexpression were investigated using a tissue microarray (TMA) containing 149 canine prostatic paraffin-embedded lesions (BPH, PIA and PCa) collected from 67 animals. Immunohistochemical reactions were performed using the polyclonal rabbit antibody anti-PTEN (Santa Cruz Biotech, 1:50) and anti-ATM (Abcam, 1:50). The sections were developed with diaminobenzidine (DAB) and peroxidase. The immunohistochemical staining was assessed in each core by the distribution of positive cells for each antibody per lesion (score 1: &amp;lt;25% cells positive, 2: 26% to 50%, 3: being 51% and 75% and 4:&amp;gt; 75%) and intensity (1: weak, 2: moderate, 3: intense). Chi-square or Fisher exact test was used to determine the association between the categorical variables using GraphPad Prism 5 (GraphPad Software Inc., La Jolla, CA). Distribution of positive cells did not differ among lesions. PCa and PIA showed more samples with weak intensity for ATM when compared to normal prostatic tissue and BPH (PCa: p=0,032 and PIA: p=0,025). Benign prostatic hyperplasia and normal samples presented intense PTEN immunostaining than PCa (p=0,021) and PIA (p=0,0013). These results suggest that ATM and PTEN proteins expression in canine prostatic carcinoma are downregulated possibly by copy number losses. These findings are similar from those described in prostate carcinomas from human corroborating for the use of dogs as a natural model to study prostatic disease in men. Citation Format: Carlos E. Fonseca Alves, Patricia R. Pellicciari, Marcela M. P. Rodrigues, Silvia R. Rogatto, Renee L. Amorim. Role of ATM and PTEN in prostatic carcinogenic dog prostate: validation of aCGH results. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 317. doi:10.1158/1538-7445.AM2013-317
RANDOMIZED TRIAL OF TENECTEPLASE OR PLACEBO WITH LOW MOLECULAR WEIGHT HEPARIN FOR ACUTE SUBMASSIVE PULMONARY EMBOLISM: ASSESSMENT OF PATIENT–ORIENTED CARDIOPULMONARY OUTCOMES AT THREE MONTHS
Authors: Jeffrey Kline, Jackeline Hernandez, Christopher Kabrhel, Daniel M. Courtney, Alan E. Jones, Kristen Nordenholtz, Deborah Diercks, James Klinger
Journal: Journal of the American College of Cardiology (2013)
A study of vertebral bone powder from patients with chronic renal failure
Authors: Michael Kaye, A. J. Frueh, M. Silverman
Journal: Journal of Clinical Investigation (1970)

Bone powder from patients dying with chronic renal failure of more than 1 yr duration was shown to release less calcium and more phosphate when equilibrated with a buffer solution. pH 7.4 at 4°C. This change persisted after removal of the organic component and was associated with a reduction in the bone carbonate content. Crystal size and surface area showed no consistent changes from the controls and it was concluded that an alteration in the apatite crystal composition had occurred in long-standing uremia with carbonate-phosphate interchange. Support for this was provided by synthesis of apatites which were carbonate deficient and behaved in a similar manner to the uremic bones.