tbuckley/cabot-search huggingface dataset:
Is There a Connection Between High Educational Debt and Suicidal Ideation Among Medical Students?
Authors: Liselotte N. Dyrbye, Jeff A. Sloan, Tait D. Shanafelt
Journal: Annals of Internal Medicine (2009)

Letters17 February 2009Is There a Connection Between High Educational Debt and Suicidal Ideation Among Medical Students?Liselotte N. Dyrbye, MD, Jeff A. Sloan, PhD, and Tait D. Shanafelt, MDLiselotte N. Dyrbye, MDFrom Mayo Clinic College of Medicine, Rochester, MN 55905.Search for more papers by this author, Jeff A. Sloan, PhDFrom Mayo Clinic College of Medicine, Rochester, MN 55905.Search for more papers by this author, and Tait D. Shanafelt, MDFrom Mayo Clinic College of Medicine, Rochester, MN 55905.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-4-200902170-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Drs. Yoon and Arora for their thoughtful letter. We agree that debt is a substantial source of stress for today's medical student. As reported, students with more than $100 000 of educational debt were 1.47 times more likely to have suicidal ideation during the previous year than students with less than $50 000 in reported debt on univariate analysis. Despite this association, debt was not independently associated with suicidal ideation during the previous year on multivariate analysis. The amount of debt that students reported was associated with other factors, such as age, relationship status, parental status, year in ... Author, Article, and Disclosure InformationAffiliations: From Mayo Clinic College of Medicine, Rochester, MN 55905.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBurnout and Suicidal Ideation among U.S. Medical Students Liselotte N. Dyrbye , Matthew R. Thomas , F. Stanford Massie , David V Power , Anne Eacker , William Harper , Steven Durning , Christine Moutier , Daniel W. Szydlo , Paul J. Novotny , Jeff A. Sloan , and Tait D. Shanafelt Is There a Connection Between High Educational Debt and Suicidal Ideation Among Medical Students? John D. Yoon and Vineet M. Arora Metrics Cited byA narrative review on burnout experienced by medical students and residents 17 February 2009Volume 150, Issue 4Page: 285KeywordsConflicts of interestForecastingMedical educationMultivariate analysis ePublished: 17 February 2009 Issue Published: 17 February 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hans O Lithell
Authors: Ilona Koupil, David Leon
Journal: BMJ (2006)

​EmeritusEmeritus professor of geriatric medicine Uppsala University, Sweden (b 1937; q Uppsala 1966; MD, PhD), died from oesophageal cancer on 27 November 2005.



Figure 1



Hans's early work on the effects of antihypertensive drugs on insulin sensitivity established his international reputation. He subsequently assembled and inspired a large team of collaborators working on various aspects of circulatory disease and diabetes. Much of this involved the unique Uppsala longitudinal study of adult men. In 1989 Hans became professor of geriatric medicine at Uppsala University and was awarded the university's Gustaf Adolf medal in 2005 for contributions to research in geriatric medicine. He leaves a wife, Ulla-Britt, and three children.
Allergic Symptoms, Atopy, and Geohelminth Infections in a Rural Area of Ecuador
Authors: Philip J. Cooper, Martha E. Chico, Martin Bland, George E. Griffin, Thomas B. Nutman
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

Geohelminth infections may affect the expression of allergic disease. To investigate the relationship between geohelminth infections, atopy, and symptoms of allergic disease, we studied 4,433 schoolchildren from 71 schools in a rural tropical area in Ecuador. Information was collected on allergic symptoms, allergen skin test reactivity, and presence of geohelminth infections. Allergic symptoms were of low prevalence (2.1% had recent wheeze), but prevalence of skin test reactivity was relatively high (18.2%). The presence of geohelminth infections was protective against allergen skin test reactivity (odds ratio 0.62, 95% confidence interval 0.50–0.76, p < 0.001) and symptoms of exercise-induced wheeze (odds ratio 0.59, 95% confidence interval 0.40–0.87, p = 0.008) but not against other wheeze symptoms or symptoms of allergic rhinitis or atopic eczema. Infection intensity with Ascaris lumbricoides or Trichuris trichiura was associated with a reduction in the prevalence of allergen skin test reactivity but not with allergic symptoms. There was no evidence of interactions between geohelminth infection and allergen skin test reactivity on the risks of allergic symptoms. The results suggest that geohelminth infections do not explain the low prevalence of allergic symptoms in the study population.
Whistleblower inquiry clears British hospital
Authors: C. Dyer
Journal: BMJ (2000)

A former professor at Imperial College School of Medicine and consultant radiologist at the Hammersmith Hospital in London who was suspended from his job after raising concerns about patient safety was not victimised, according to the conclusions of an independent inquiry released last week.

Peter Dawson, who resigned with a £120000 ($180000) settlement and now works for University College London Hospitals, branded the public presentation of the report by Ian Cameron, vice chancellor of the University of Wales College of Medicine, as “a cover-up and a whitewash.” But he …
The Effect of Tocotrienols Added to Canola Oil on Microalbuminuria, Inflammation and Nitrosative Stress in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Mohammadreza Vafa, Neda Haghighat, Shahriar Eghtesadi, Iraj Heydari
Journal: Journal of the American College of Cardiology (2013)
Multifocal Pyomyositis
Authors: Robert Howman-Giles, David McCAULEY, John Brown
Journal: Clinical Nuclear Medicine (1984)

Pyomyositis is a bacterial infection of skeletal muscle occurring in the absence of trauma or a primary site of infection. The condition is rare in temperate climates. The diagnosis is often difficult to make and frequently delayed since the suppurative process is confined by the tense overlying muscle and fascia. The bone scan is very useful in differentiating underlying osteomyelitis and septic arthritis. An 11-year-old boy is described who presented with multifocal pyomyositis in the elbow region and thigh. Lateral blood pool images suggested infection with liquefaction within the muscles without evidence of osteomyelitis.
Drug points: Reversible deterioration of renal function after diclofenac in patient receiving triamterene
Authors: M. Harkonen, S. Ekblom-Kullberg
Journal: BMJ (1986)

2500 in Sweden, 3900 in the UK, and 4000 in France to 11155 in West Germany and 12000 in the USA.Since the markets of the developed world do not collectively appear to support such enormous numbers of products, it is surprising that such numbers whichare claimed to exist in hird World markets are attributed to exports from the Western world.J P GRMIN ABPI, London SWIA 2DY Does sodium restriction lower blood pressure?SIR,-Dr M R Lee and colleagues (26 July, p 266) suggest that hypertension in blacks is different from that in white people and may be more salt dependent.In rural Belize the Creoles, an Afro- Caribbean group, certainly had higher blood pres- sures than either an Amerindian (Mayan) or Amerindian-European (Mestizzo) group.'How- ever, when Creoles were compared with rural and urban Malawians (central Africans) studied using the same epidemiological techniques2 the urban Africans had the highest blood pressures.This was in spite of the urban Africans being younger, lighter and less obese and having a lower output of overnight urinary sodium than the Creoles (table ).Obviously factors other than salt intake have caused these differences and, they may not all be environmental.It may be that genetic differences between Afio-Caribbean communities are as im- portant as those between whites and blacks, and Mean blood pressres, ages, weight, body mass indx, and overnght winary sodium osuput Creoles Urban Malawians Rural Malawians Men Women Men Women Men Women Blood pressure (mm Hg) 124/66-6 115/65-4 127-5*/76-2
Wakefield admits fabricating events when he took children’s blood samples
Authors: Owen Dyer
Journal: BMJ (2008)

Seizures cause retrograde amnesia. We have previously demonstrated that seizures erode recently formed memories through shared ensembles and mechanisms in the CA1 region of the hippocampus. Here, we tested whether seizure circuits overlap spatial memory circuits outside of the CA. Spatial memory is consolidated by the hippocampal-cortical coupling that are connected via multiple pathways. We tested whether a seizure invades structures involved in memory consolidation by using the activity reporter TRAP2 mice. T-maze alternation learning activated neurons in the dentate gyrus, mediodorsal thalamus, retrosplenial cortex, and medial prefrontal cortex. This spatial memory relies on the plasticity of the AMPA receptor GluA1 subunit. GluA1 knockout/TRAP2 mice did not learn to alternate, and structures interposed between the hippocampus and the cortex were not active. A seizure prevented the recall of alternation memory and activated memory-labeled structures. There was a widespread overlap between learning-activated ensembles and seizure-activated neurons, which likely contributes to retrograde amnesia. <b>Significance Statement</b> We propose that seizures cause retrograde amnesia by engaging the circuits that participate in memory consolidation.
745 eGFR IMPROVEMENT IN CHRONIC HEPATITIS B PATIENTS WITH TELBIVUDINE TREATMENT IS INDEPENDENT OF ANTIVIRAL ACTIVITY
Authors: E.J. Gane, Y.F. Liaw, Y. Wang, C.-L. Lai, J. Rasenack, S. Zeuzem, H.L.Y. Chan, H. Ren, Y. Dong, A. Uddin, M.E. Jung, S. Bosset, A. Trylesinski
Journal: Journal of Hepatology (2013)
Junk Mail and Mother Earth
Authors: JOE D. HULL
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 May 1972Junk Mail and Mother EarthJOE D. HULL, M.D.JOE D. HULL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-837_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the 6 months from 1 July 1971 through 1 January 1972 I saved each piece of unsolicited mail I received as a medical resident. The quantities for each of five categories are shown here:Judging from the bulging mailboxes of my colleagues, I received an average amount of junk mail. There are 67 384 interns and residents in this country (1). Multiplying this figure by the weight of my mail by two gives a grand total of 8 456 692 pounds of junk advertising mail received per year by house officers. This figure does not include...References1. Medical education in the United States, 1970-1971. JAMA 218:1232, 1236, 1971 Google Scholar2. SWATEK P: The User's Guide to the Protection of the Environment, pg. 125. Google Scholar3. GREENWALD A: Give-away medical journals (Letter). JAMA 217:1705, 1971 CrossrefGoogle Scholar4. HEYDE E: HOW to get rid of junk mail (Letter). Ann Intern Med 72:964, 1970 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston University Medical Service Boston City Hospital PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 837-837 ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Updated Hodgkin's disease: B. Curability of localized disease. Comment: The mantle failure: The transdiaphragmatic extension
Authors: P. Rubin
Journal: JAMA (1973)

The major impetus for the development of new techniques of treatment is the failure of an existing technique. In the early sixties, the introduction of pedal lymphangiography to exclude infradiaphragmatic nodes promised precise definition of localized stage I and II Hodgkin's disease. The use of megavoltage irradiation through a shaped mantle field to treat the nodal disease and adjacent sites above the diaphragm promised cure, since adequate tumoricidal doses could be delivered. The "mantle technique" controlled approximately 50% to 60% of all such patients, as documented in numerous series.<sup>58</sup>The pattern of failure was consistent; the vast majority of patients had a transdiaphragmatic extension of disease, most often involving the para-aortic lymph nodes or the spleen. The transdiaphragmatic extension to the para-aortic lymph node region has been a central focus of discussion. Its subsequent appearance despite negative lymphangiograms has led to speculations about its development. The most controverted concept
Treatment of malignant intracranial germ cell tumours.
Authors: S. Senan
Journal: BMJ (1992)

On admission hewas semiconscious and scored 9 on the Glasgow coma score.He showed writhing movements of his hands and subsequently had a short tonic-clonic fit.Both his plantar responses were extensor, but the remainder of the physical examination gave normal results.Initial investiga- tions showed a serum sodium concentration of 121 mmol/l, potassium 3 9 mmol/l, and chloride 90 mmol/l with a creatinine concentration of 54 [tmol/l and osmolarity of 254 mmol/l.A com-
Evolutionary Advantage Conferred by an Eukaryote-to-Eukaryote Gene Transfer Event in Wine Yeasts
Authors: Souhir Marsit, Adriana Mena, Frédéric Bigey, François-Xavier Sauvage, Arnaud Couloux, Julie Guy, Jean-Luc Legras, Eladio Barrio, Sylvie Dequin, Virginie Galeote
Journal: Molecular Biology and Evolution (2015)

Although an increasing number of horizontal gene transfers have been reported in eukaryotes, experimental evidence for their adaptive value is lacking. Here, we report the recent transfer of a 158-kb genomic region between Torulaspora microellipsoides and Saccharomyces cerevisiae wine yeasts or closely related strains. This genomic region has undergone several rearrangements in S. cerevisiae strains, including gene loss and gene conversion between two tandemly duplicated FOT genes encoding oligopeptide transporters. We show that FOT genes confer a strong competitive advantage during grape must fermentation by increasing the number and diversity of oligopeptides that yeast can utilize as a source of nitrogen, thereby improving biomass formation, fermentation efficiency, and cell viability. Thus, the acquisition of FOT genes has favored yeast adaptation to the nitrogen-limited wine fermentation environment. This finding indicates that anthropic environments offer substantial ecological opportunity for evolutionary diversification through gene exchange between distant yeast species.
Hepatotoxicity with Combination of Vemurafenib and Ipilimumab
Authors: Antoni Ribas, F. Stephen Hodi, Margaret K. Callahan, Cyril Konto, Jedd D. Wolchok
Journal: New England Journal of Medicine (2013)

The independent mechanisms of action and largely nonoverlapping toxicity profiles of vemurafenib and ipilimumab made it logical to test them together in a study of patients with melanoma. An unexpected level of hepatic toxicity caused the early termination of the study.
Pulmonary aspergillosis caused by Aspergillus flavus
Authors: E. S. Mahgoub, A. M. El Hassan
Journal: Thorax (1972)

Bronchopulmonary aspergillosis is usually caused by <i>Aspergillus fumigatus.</i> The six cases from the Sudan reported here were due to <i>Aspergillus flavus.</i> Three of the patients had primary invasive disease, one had Aspergillus mycetoma in a pre-existing lung cavity, and two had allergic aspergillosis. A special feature of the invasive disease was the clinical and radiographic simulation of malignancy, particularly in one patient who had multiple disseminated nodules of fungal granulomata in the skin of the lower abdomen.
Natural family planning: Only as reliable as people
Authors: R. M Conroy
Journal: BMJ (1993)

often does not have the same motivation, and, particularly in developing countries, a woman may have an unequal say in such a decision.If she feels unhappy living with such uncertainty and decides, from purely unselfish motives, to try a more reliable method of birth control, it is she who has to bear all the guilt imposed on her by the Catholic church.Surely such a situation can have been created only by men, and men with no understand- ing of the problems faced by women.ANNEJEWELL
The Bradshaw Lecture ON ANGINA PECTORIS: SOME POINTS IN PROGNOSIS: Delivered before the Royal College of Physicians of London
Authors: J. Hay
Journal: BMJ (1923)

B. ETIOLOGY OF CHRONIC ULCER.The opinion has already been expressed that a chronic ulcer is merely an acute ulcer which has lasted a certain lengthl of time.What, then, are the factors which prevent ani acute ulcer from healing?In most of the experimental work which.hasbeen done on this subject the acute ulcers liave healed with great readiness and in quite a short time (two or three weeks), and the difficulty has been, not to get them to heal, but to devise means to prevent them from healing-that is, to convert them into chlronic ulcers, comparable to those met with in man.
(16) High altitude and the skin
Authors: J.S.C. English
Journal: British Journal of Dermatology (1987)

Most high-altitude medical research has been concerned with cardio-pulmonary pathophysiology. As medical officer to the 1986 British North East Ridge Everest Expedition, I was able to study the effects of prolonged high altitude exposure on the skin. The environment is very harsh on Everest (29 048 feet) with strong winds, low humidity and temperatures as low as - 25°C. The 23 members of the expedition spent 3 months at or above 17000 feet. The highest altitude reached was 25750 feet. Several skin conditions were encountered: frostbite, chillblains, fissuring of finger pulps, dry skin, eczema, folliculitis, sunburn and polymorphic light eruption. The most interesting finding was that six members developed numerous splinter haemorrhages. This may reflect a more widespread capillary fragility which occurs at high altitudes,1 and may be important in the pathogenesis of high-altitude pulmonary and cerebral oedema.
A connectionist theory of phenomenal experience
Authors: Gerard O'Brien, Jonathan Opie
Journal: Behavioral and Brain Sciences (1999)

When cognitive scientists apply computational theory to the problem of phenomenal consciousness, as many have been doing recently, there are two fundamentally distinct approaches available. Consciousness is to be explained either in terms of the nature of the representational vehicles the brain deploys or in terms of the computational processes defined over these vehicles. We call versions of these two approaches vehicle and process theories of consciousness, respectively. However, although there may be space for vehicle theories of consciousness in cognitive science, they are relatively rare. This is because of the influence exerted, on the one hand, by a large body of research that purports to show that the explicit representation of information in the brain and conscious experience are dissociable, and on the other, by the classical computational theory of mind--the theory that takes human cognition to be a species of symbol manipulation. Two recent developments in cognitive science combine to suggest that a reappraisal of this situation is in order. First, a number of theorists have recently been highly critical of the experimental methodologies used in the dissociation studies--so critical, in fact, that it is no longer reasonable to assume that the dissociability of conscious experience and explicit representation has been adequately demonstrated. Second, classicism, as a theory of human cognition, is no longer as dominant in cognitive science as it once was. It now has a lively competitor in the form of connectionism; and connectionism, unlike classicism, does have the computational resources to support a robust vehicle theory of consciousness. In this target article we develop and defend this connectionist vehicle theory of consciousness. It takes the form of the following simple empirical hypothesis: phenomenal experience consists of the explicit representation of information in neurally realized parallel distributed processing (PDP) networks. This hypothesis leads us to reassess some common wisdom about consciousness, but, we argue, in fruitful and ultimately plausible ways.
MYOCARDIAL TISSUE LEVELS OF PROTEIN ARGININE N-METHYLTRANSFERASE 1 (PRMT-1) AND DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) IN THE HUMAN FAILING HEART ARE INFLUENCED BY RAISED INTRACARDIAC FILLING PRESSURES
Authors: Zhili Shao, Wendy E. Sweet, Matthew Baumann, Christine S. Moravec, Wai Hong Wilson Tang
Journal: Journal of the American College of Cardiology (2010)
OPERATIONS FOR SECONDARY CATARACT.
Authors: PETER A. CALLAN
Journal: JAMA (1907)

The ideally perfect cataract extraction should consist of a method involving a minimum of risk, without sequelæ demanding subsequent interference to obtain good vision. The extraction of the opaque lens within its capsule appeals to us all, but the consensus of opinion regards this operation as not safe as a routine method. Most ophthalmic surgeons extract cataracts without the capsule, leaving the latter to cause subsequent operative measures necessary in the majority of cases. Various capsular forceps have been devised to obviate the formation of secondary cataracts. With the forceps the attempt is made to remove the anterior capsule within the area of the pupil, so as to secure a clear opening after the removal of the opaque lens. I have never been able to satisfy myself that the forceps had rendered subsequent secondary cataracts less numerous than when the cystotome had been used, but this may have been the
Imaging of a Paraganglioma on C-11 Choline PET/CT
Authors: Kambiz Rahbar, Martin Fuchs, Sebstian Kemper, Kai U. Juergens, Matthias Weckesser, Lars Stegger
Journal: Clinical Nuclear Medicine (2009)

Positron emission tomography combined with computed tomography (PET/CT) using C-11- or F-18-labeled choline as a radiotracer is increasingly used for the evaluation of prostate cancer. Distinguishing between manifestations of prostate cancer and unrelated uptake can be difficult. We report a patient with prostate cancer and an incidental finding of a paraganglioma with high C-11 choline uptake. Therefore, neuroendocrine tumors should be considered in the differential diagnosis in patients with focal choline uptake. The diagnostic value of choline positron emission tomography combined with computed tomography for the evaluation of neuroendocrine tumors is, however, limited due to the high physiological uptake in liver, spleen, pancreas, and the gastrointestinal tract.
Selective removal of anti-double-stranded DNA antibodies by immunoadsorption with dextran sulphate in a patient with systemic lupus erythematosus.
Authors: M Kinoshita, S Aotsuka, T Funahashi, N Tani, R Yokohari
Journal: Annals of the Rheumatic Diseases (1989)

A dextran sulphate gel column removed anti-double-stranded DNA antibodies (anti-dsDNA) selectively, efficiently, and safely from the circulation of a patient with systemic lupus erythematosus (SLE). The mechanism of the removal is thought to be due to cross reactivity of anti-dsDNA with dextran sulphate, which has negatively charged units. Selective removal of anti-dsDNA is expected to contribute not only to the treatment but also to elucidation of the pathogenesis of SLE.