tbuckley/cabot-search huggingface dataset:
Indications for Tonsillectomy
Authors: Truett V. Bennett
Journal: JAMA (1967)

To the Editor:—  Dr. Robert Lawson's reply in QUESTIONS AND ANSWERS ( 200 :1138, 1967) indicates that he thinks tonsillectomies with adenoidectomy (T&A) are practically never indicated. At the risk of sounding old-fashioned, I would like to differ with that opinion.  We cannot ignore the clinical observation, so readily discerned by both physician and parent, where-by the child is obviously in poor health, underweight, breathing noisily, and having attacks of fever every few weeks, and then after a T&A shows almost an overnight improvement in appearance.  The fact that 90% of children's throat infections are viral is not very significant, because it does not indicate the percentage of children having these infections. The 10% of bacterial throat infections concentrated in 5% of children would leave this small percentage disabled by the frequency thereof. If these infections can be eliminated or significantly decreased by a relatively minor surgical procedure, I see no
Should the Resting Electrocardiogram Be Ordered as a Routine Risk Assessment Test in Healthy Asymptomatic Adults?
Authors: Philip Greenland
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accidental endoscopic piercing of the tongue with an Ovesco clip
Authors: B. Mangiavillano, E. Morandi, E. Masci
Journal: Endoscopy (2012)

A 77-year-old woman was sent to our center for radiological investigation of a suspect pancreatic lesion. A computed tomography (CT) scan with contrast had been performed of a malignant pancreatic neoplasia invading mesenteric vessels and conditioning jaundice. Under deep sedation with intravenous propofol (Diprivan; Astra Zeneca, Wilmington, Delaware, North Carolina, USA), the patient underwent endoscopic ultrasound to stage the lesion. During the passage of the endoscope between the stomach and duodenum, we observed a 15-mm diameter, full-thickness lesion on the posterior wall of the duodenal bulb, just above the duodenal knee.
The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis
Authors: Emma C Nilsson, Rickard J Storm, Johannes Bauer, Susanne M C Johansson, Aivar Lookene, Jonas Ångström, Mattias Hedenström, Therese L Eriksson, Lars Frängsmyr, Simon Rinaldi, Hugh J Willison, Fatima Pedrosa Domellöf, Thilo Stehle, Niklas Arnberg
Journal: Nature Medicine (2010)
NEURASTHENIA ESSENTIALIS AND NEURASTHENIA SYMPTOMATICA.
Authors: F. X. DERCUM
Journal: JAMA (1898)

At the present day there exist, not only in the mind of the general practitioner, but even in that of the specialist, the most vague and ill defined notions concerning neurasthenia. Not only do we hear from physicians of the highest standing allusions made and views expressed in regard to neurasthenia which disclose that this all important affection has never received serious study or attention by them, but this is true to a very large extent of neurologists and especially alienists. A striking illustration of this proposition is furnished by the treatise on the pathology and therapy of neurasthenia, by Binswanger, which has recently made its appearance in Germany. This writer does not hesitate to say that under neurasthenia we are to group all neuropathic appearances which rest on a basis of a general functional disease of the nervous system but which can not be placed in the same category
A Hypercoagulable State in the Left Atrium of Patients with Mitral Stenosis
Authors: Keiji Yamamoto, Uichi Ikeda, Kazuyuki Shimada
Journal: New England Journal of Medicine (1993)

To the Editor: Thromboembolism is a frequent and serious complication of valvular heart disease, particularly mitral stenosis1,2. Recently, sensitive molecular markers for assessing thrombotic and fibrinolytic states have been identified3. We measured the levels of these markers in blood from a peripheral vein, the right atrium, and the left atrium of eight patients with mitral stenosis who were undergoing percutaneous mitral valvuloplasty. The study group consisted of three men and five women (mean age, 53 years; range, 39 to 61) with rheumatic mitral stenosis (mean mitral-valve area, 0.69 ±0.06 cm2) but without left atrial thrombus. Seven . . .
Deafness from Furosemide
Authors: THOMAS VARGISH
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 May 1970Deafness from FurosemideTHOMAS VARGISH, 4th year medical student, ROBERT BENJAMIN, M.D., LOUIS SHENKMAN, M.D.THOMAS VARGISH, 4th year medical studentSearch for more papers by this author, ROBERT BENJAMIN, M.D.Search for more papers by this author, LOUIS SHENKMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-761_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In treating a 32-year-old Puerto Rican man with uremia and chronic renal disease, we referred to a recent article by R. G. Muth, "Diuretic Properties of Furosemide in Renal Disease" (Ann Intern Med69: 249-261, 1968). Our patient had ascites and peripheral edema due to dietary indiscretions with a 26-lb weight gain. We decided to follow Dr. Muth's regimen for highdosage furosemide therapy. We started the patient on increasing daily doses of oral furosemide over a 10-day period until the daily dose reached 3 g. At this time there was almost no effective diuresis so we switched... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: NYU-Bellevue Medical Center New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGenetics of guanylyl cyclase pathways in the cochlea and their influence on hearingUltrafiltration and Heart FailureUltrafiltration and Heart FailureNkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larvaDiuretics: Still the mainstay of treatmentAntenatal Bartter syndrome with sensorineural deafness: refinement of the locus on chromosome 1p31Linkage of Infantile Bartter Syndrome with Sensorineural Deafness to Chromosome 1pUltrastructural Histopathology in a Case of Human Ototoxicity Due to Loop DiureticsElimination Kinetics of Furosemide in Perilymph and Serum of the Chinchilla: Neuropharmacologic CorrelatesReactions to furosemideDrug OtotoxicityOtologic symptoms in chronic renal failure. The possible role of aminoglycoside-furosemide interactionComparison of the cochlear toxicity of sodium ethacrynate, furosemide, and the cysteine adduct of sodium ethacrynate in catsPermanent Deafness Associated with Furosemide AdministrationExperimentelle Untersuchungen zur Ototoxicität des Furosemids 1 May 1970Volume 72, Issue 5Page: 761-761KeywordsAscitesDeafnessDiureticsEdemaHispanic peopleRenal diseasesWeight gain Issue Published: 1 May 1970 PDF downloadLoading ...
Local recurrence rates in the conserved breast after MRI targeted radiotherapy.
Authors: MJ Beresford, E Whipp, E Sawyer, M Halliwell
Journal: Cancer Research (2009)

Abstract Abstract #5143 Background: To optimise the effects of whole breast irradiation after breast conservation surgery, precise identification and delineation of clinical target volumes is essential. If the site of the “post-operative cavity” (POCx) is inaccurately located, any target miss of residual cancer cells may lead to underdosing and thus impact on local recurrence rates and survival. Studies with surgical clips have shown rates of geographical miss of the POCx to be worryingly high for radiotherapy boost doses (up to 87%). Of even more concern is that the whole breast tangential fields frequently miss the tumour bed even though the fields appear adequate based on external landmarks (in approximately a quarter of cases). MRI has subtle breast tissue characterisation that may demonstrate post-operative detail more clearly than CT and more accurately than surgical clips.&amp;#x2028; Methods and Materials: Simple opposed tangential fields were defined by surface anatomy in the conventional manner in 221 consecutive patients. Following MR imaging, fields were modified by a single radiation oncologist (EW) to encompass the POCx with a 10mm margin. Patients were treated to a dose of 45Gy in 20 fractions or 50Gy in 25 fractions, with or without an electron boost to the tumour bed (usually 12.5Gy in 5 fractions). Genetic analysis, using genome wide single nucleotide polymorphism (SNP) arrays and loss of heterozygosity (LOH), was performed on all local relapses to distinguish true recurrences (TRs) from new primaries (NPs)&amp;#x2028; Results: This cohort was at relatively high risk, with only 9.8% classified as low risk by St Gallen criteria. 43.4% were grade 3 and 19.9% had surgical margins &amp;lt;1mm. 62.4% of patients received boosts to the tumour bed. After a median follow-up of 5 years there were 3 local recurrences. This is an actuarial 5-year local relapse rate of 1.3%. Genetic analysis showed that 2 local relapses had identical genetic profiles to the initial primaries; they were TRs. The other was genetically distinct; it was an NP.&amp;#x2028; Conclusions: In this cohort of relatively high risk patients, the TR rate was 0.9% at 5 years. These figures compare favourably with the EORTC boost trial and the START results, although both of these studies had different inclusion criteria, particularly with regard to surgical margins. Theoretically, TRs should be the type of relapse most likely to be avoided by accurate coverage of the post-operative complex. Radiotherapy planned with guidance from MR images may cover the clinical target volume more accurately than treatment guided by anatomical landmarks alone. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 5143.
Allergen‐Specific IgE Antibodies against Antigenic Components in Cow Milk and Milk Substitutes
Authors: B. Gjesing, O. ØSterballe, B. Schwartz, U. Wahn, H. Lowenstein
Journal: Allergy (1986)

Crossed radioimmunoelectrophoresis (CRIE) was used to study the presence of serum IgE against antigenic components of cow milk in 21 selected milk-allergic patients. The amount of each IgE specificity was estimated by a scoring system. The milk-allergic children had mainly IgE against alpha-lactalbumin, beta-lactoglobulin, albumin and immunoglobulin, the four major proteins of bovine whey, as well as IgE against three casein components. A serum pool from 1000 normal adults had IgE against the same whey protein, but in smaller amounts, and no IgE against the casein components. Eight cow milk-based formulae, commonly used for infant feeding, and goat milk were studied by the same method. It was found that six of the milk substitutes did not differ significantly from cow milk in antibody binding, but the two hydrolysed casein products, Nutramigen and Pregestimil, consisted of such small molecules that the rabbit antisera could not precipitate the hydrolysed proteins in the gels on the CRIE plates. It was therefore not possible to study their IgE binding, if any, by this method.
Abstract 3161: Race/Ethnicity is an Independent Predictor of Atrial Fibrillation among Individuals 60 Years and Older
Authors: Albert Yuh-Jer Shen, Serap Sobnosky, May J Liu, Anne M Ichiuji, Ahmed I Shah, Wansu Chen
Journal: Circulation (2008)

Atrial fibrillation (AF) is present in 4 – 8% of people 60 years and older based on studies of predominantly white populations. Limited data involving specific disease states (e.g., HF and acute coronary syndromes) suggest that AF prevalence in blacks and Asians are approximately half that of whites. Scarce data exist regarding racial/ethnic differences in AF prevalence in US communities. This is a cross-section, observational study. In 2005, there were 467,087 members in the Kaiser Permanente Southern California health plan aged 60 years or older. By searching ICD-9 codes and electronic ECG archives, we identified all members in this age group with AF. Patients with pulmonary embolism, thyroid, pericardial, rheumatic, other valvular diseases and early post-cardiac surgery AF cases were excluded. Race/ethnicity data was assigned administratively using hospital-based service utilization, surname, and geocoding methods and was available for 74.1% of members (73% of non-AF and 89.8% of AF), 99% of which belonged to one of the following 4 groups: white, black, Asian, and Hispanic. The independent effect of race/ethnicity on AF was analyzed with logistic regression methods adjusting for potential confounders (search period 2003–5): age, gender, duration of membership, education attainment, household income, prior stroke, diabetes, hypertension, heart failure, chronic kidney disease, coronary artery disease, COPD, morbid obesity and sleep apnea. Among members aged 60 years and older, selected prevalent AF risk factors are listed in the table . The overall AF prevalence was 6.8%. Among members whose race/ethnicity was known, AF was most prevalent in whites. The odds ratios of having AF among nonwhites were substantially lower than whites in our crude and adjusted logistic regression models. White race/ethnicity is associated with a greater risk for AF after adjusting for comorbidities associated with the development of AF.
Rebuttal to editorial saying cancer survival statistics are misleading
Authors: M. P. Coleman, B. Rachet, L. Woods, F. Berrino, J. Butler, R. Capocaccia, P. Dickman, A. Gavin, R. Giorgi, W. Hamilton, P. Lambert, M. D. Peake, M. P. Perme, J. Stare, P. Vedstedt
Journal: BMJ (2011)

Dr Godlee "UK cancer survival statistics are misleading and make survival look worse than it is": rebuttal This editorial is unfounded, untenable and inconsistent.
A Peculiar Form of Scarlatina
Authors: N. Heckford
Journal: BMJ (1868)

THE BRITISH MEDICAL OURNAL.54 culosis with emaciation, the earthy phosphates are increased.Com- petent observers have decided that mental excitement and intellectual exertion increase the amount of urinary water, increase also the urea, chlorine, sulphuric and phosphoric acids, notably the latter, and lessen the amount of uric acid.Yet, in the six cases of our first series, the Pc5 was only decreased in two of the cases of low delicum, in which we P0'hardly speak either of mental excitement or intellectual exertion; in- crease of PO'5 occurred in three cases, one of which was delirium tremens; whilst of those in which no delirium existed, there was great increase of POS in the case of fatuity, great increase in the case of hemiplegia, with acute cerebral softening, with the mind quite clear and calm, and con- siderable increase in the chorea; whilst in the case of phthisis the in- crease was small, although delusions of a most horrible character
Indirect Action of Epinephrine on Intraventricular Conduction Time
Authors: CARLOS MENDEZ, DAVID ERLIJ, GORDON K. MOE
Journal: Circulation Research (1964)

In dogs with denervated hearts intravenous infusions of epinephrine (1.0 to 3.0 µg/kg/min) caused marked acceleration of the heart rate and a significant reduction of intraventricular conduction time. Equal doses infused into the descending thoracic aorta increased the heart rate only slightly, but exerted undiminished effects upon conduction time. Evisceration did not modify the intraventricular dromotropic effect of epinephrine so long as the hepatic arterial supply was preserved. Occlusion of the hepatic artery abolished the dromotropic effect of epinephrine without modifying its chronotropic action. The time course of the dromotropic effect and of the kalemic action of epinephrine was approximately the same. Intravenous infusions of KCl matching the hyperkalemic effect of epinephrine caused similar dromotropic actions. Isoproterenol even in high doses (up to 2.0 µg/kg/min) did not decrease intraventricular conduction time and had only a slight hyperkalemic effect. After the administration of SY28 (1.0 mg/kg) epinephrine caused neither hyperkalemia nor decreased intraventricular conduction time. It is concluded that in the heart in situ the effect of epinephrine on intraventricular conduction is the result of an indirect action mediated through the liberation of K + ions from the liver.
Reversibility of Unawareness of Hypoglycemia in Patients with Insulinomas
Authors: A. Mitrakou, C. Fanelli, T. Veneman, G. Perriello, S. Calderone, D. Platanisiotis, A. Rambotti, S. Raptis, P. Brunetti, P. Cryer, J. Gerich, G. Bolli
Journal: New England Journal of Medicine (1993)

A lack of appropriate autonomic warning symptoms before the development of neuroglycopenia occurs frequently in patients with diabetes mellitus. The pathogenesis of this phenomenon is unclear, but it is associated with intensive insulin therapy, prolonged duration of diabetes, frequent episodes of hypoglycemia, and impaired glucose counterregulation. Recently, it has been proposed that repeated episodes of hypoglycemia may themselves induce the phenomenon.
CARDIOVASCULAR, RENAL, AND GENERAL EFFECTS OF LARGE, RAPID PLASMA INFUSIONS IN CONVALESCENT MEN 1
Authors: Jesse R. Wilson, Clinton R. Harrison, Leonard L. Taylor, Charles E. Knight, William F. Haines
Journal: Journal of Clinical Investigation (1950)

Clinicians and investigators generally agree that fluid replacement in the treatment of shock due to blood loss should be rapid.It is common teaching, however, that intravenous fluids are best given slowly when shock is not being cor- rected.In this study reconstituted human plasma was given rapidly by vein to 10 convalescent males in order to observe the cardiovascular, renal, and general effects on individuals with normal blood volumes.Amounts of plasma from 900-1955 cc.given in 5%-60 minutes were well tolerated. REVIEW OF LITERATUREThere have been numerous studies of the effects of the intravenous injection of large amounts of fluids into animals (1-16) and into man (17- 25).Eyster and Middleton (17) found that in- jection of about 1%o of body weight of blood in 10- 14 minutes into cases of primary anemia caused transitory changes in blood and venous pressures and insignificant alterations in heart size.Caughey (18) gave cardiacs 1500 cc. of saline in 30 min- utes, noting rise of venous pressure followed by a very slow fall, and failure of the venous pressure to subside quickly after infusion has been used by Richards, Caughey, et al. ( 19) as a test for heart failure.Gilligan et al. (20, 21) gave saline and/or glucose in varying concentrations in amounts up to 1500 cc. at rates up to 71 cc. per minute to sub-
Induction of Vascular Progenitor Cells From Endothelial Cells Stimulates Coronary Collateral Growth
Authors: Liya Yin, Vahagn Ohanyan, Yuh Fen Pung, Angelo DeLucia, Erin Bailey, Molly Enrick, Kelly Stevanov, Christopher L. Kolz, Giacinta Guarini, William M. Chilian
Journal: Circulation Research (2011)

Rationale: A well-developed coronary collateral circulation improves the morbidity and mortality of patients following an acute coronary occlusion. Although regenerative medicine has great potential in stimulating vascular growth in the heart, to date there have been mixed results, and the ideal cell type for this therapy has not been resolved. Objective: To generate induced vascular progenitor cells (iVPCs) from endothelial cells, which can differentiate into vascular smooth muscle cells (VSMCs) or endothelial cells (ECs), and test their capability to stimulate coronary collateral growth. Methods and Results: We reprogrammed rat ECs with the transcription factors Oct4, Klf4, Sox2, and c-Myc. A population of reprogrammed cells was derived that expressed pluripotent markers Oct4, SSEA-1, Rex1, and AP and hemangioblast markers CD133, Flk1, and c-kit. These cells were designated iVPCs because they remained committed to vascular lineage and could differentiate into vascular ECs and VSMCs in vitro. The iVPCs demonstrated better in vitro angiogenic potential (tube network on 2-dimensional culture, tube formation in growth factor reduced Matrigel) than native ECs. The risk of teratoma formation in iVPCs is also reduced in comparison with fully reprogrammed induced pluripotent stem cells (iPSCs). When iVPCs were implanted into myocardium, they engrafted into blood vessels and increased coronary collateral flow (microspheres) and improved cardiac function (echocardiography) better than iPSCs, mesenchymal stem cells, native ECs, and sham treatments. Conclusions: We conclude that iVPCs, generated by partially reprogramming ECs, are an ideal cell type for cell-based therapy designed to stimulate coronary collateral growth.
Formula Manufacture and Infant Feeding
Authors: Lewis A. Barness
Journal: JAMA (1980)

Wolfsdorf and Senior (p 1068) clearly document the detrimental effects of low chloride feeding of infants. The cases of alkalosis produced in two infants were due to an error in the manufacture of infant formulas, raising broad questions. The American Academy of Pediatrics<sup>1</sup>has recommended that infants be breast-fed, most recently because of the anti-infective properties of human milk. Yet all mothers cannot or will not nurse their infants, and because of multiple pressures many mothers cannot nurse their infants as long as they would like. Human milk substitutes must be used. Originally substitutes were largely based on dilutions of animal milks. With better understanding of the infant gastrointestinal system, these milks have been wisely modified so that the fat is replaced with vegetable fat, which is more easily absorbed, the protein and electrolytes have been lowered to more physiological levels, vitamins and minerals have been added, and other