tbuckley/cabot-search huggingface dataset:
Abnormal Chest Roentgenogram in a Patient With Hemoptysis
Authors: Stephen G. Jenkinson
Journal: JAMA (1979)

<h3>History</h3> A previously healthy 49-year-old woman had hemoptysis of one month's duration. She had no chest pain, shortness of breath, or weight loss. She had a history of cigarette smoking for more than 20 years and denied any exposure to tuberculosis or other infectious pulmonary diseases. The patient was afebrile, and examination of the chest disclosed decreased breath sounds in the right upper chest anteriorly. There was no cyanosis or clubbing, and the rest of her physical examination was within normal limits. Routine laboratory data were unremarkable. Figures 1 and 2 are posteroanterior and lateral roentgenograms taken on admission. <h3>Diagnosis</h3> Bronchogenic carcinoma with collapse of the right upper lobe exhibiting the S sign of Golden. <h3>Comment</h3> The posteroanterior chest film (Fig 1) shows the reverse S-shaped curve often seen with collapse of the right upper lobe<sup>1,2</sup>(Fig 3, retouched). The lateral view (Fig 2) confirms the upper lobe collapse.
Sulphasalazine induced renal failure.
Authors: A D Dwarakanath, J Michael, R N Allan
Journal: Gut (1992)

Two men with longstanding ulcerative colitis who were treated with sulphasalazine for several years and who developed chronic renal failure are reported. Renal biopsy specimens showed histological changes consistent with drug induced chronic intestinal nephritis. Extensive investigation made other causes of chronic renal failure unlikely. One of these patients underwent renal transplantation, the other has impaired but stable renal function.
Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy.
Authors: Christian G Daughton
Journal: Environmental Health Perspectives (2002)

Since the 1980s, the occurrence of pharmaceuticals and personal care products (PPCPs) as trace environmental pollutants, originating primarily from consumer use and actions rather than manufacturer effluents, continues to become more firmly established. Although PPCPs typically have been identified in surface and ground waters, some are also undoubtedly associated with solid phases such as suspended particulates, sediments, and sewage sludges, despite their relatively high affinity for water. Often amenable to degradation, their continual introduction to waste-receiving waters results from their widespread, continuous, combined use by individuals and domestic animals, giving PPCPs a "pseudo-persistence" in the environment. Little is known about the environmental or human health hazards that might be posed by chronic, subtherapeutic levels of these bioactive substances or their transformation products. The continually growing, worldwide importance of freshwater resources, however, underscores the need for ensuring that any aggregate or cumulative impacts on (or from) water supplies are minimized. Despite the paucity of effects data from long-term, simultaneous exposure at low doses to multiple xenobiotics (particularly non-target-organism exposure to PPCPs), a wide range of proactive actions could be implemented to reduce or minimize the introduction of PPCPs to the environment. Most of these actions fall under what could be envisioned as a holistic stewardship program--overseen by the health care industry and consumers alike. Significantly, such a stewardship program would benefit not just the environment; additional, collateral benefits could automatically accrue, including reducing consumers' medication expenses and improving patient health and consumer safety. In this article, the first of a two-part mini-monograph describing the "green pharmacy," I focus initially on the background behind the imperative for an ecologically oriented stewardship program for PPCPs. I then present a broad spectrum of possible source control/reduction actions, controlled largely by the health care industry, that could minimize the disposition of PPCPs to the environment. This two-part mini-monograph attempts to capture cohesively for the first time the wide spectrum of actions available for minimizing the release of PPCPs to the environment. A major objective is to generate an active dialog or debate across the many disciplines that must become actively involved to design and implement a successful approach to life-cycle stewardship of PPCPs.
[175] SPECIFIC ANTI-HCV IMMUNE RESPONSES AFTER LIVER TRANSPLANTATION IN HIV/HCV CO-INFECTED PATIENTS
Authors: A. Samri, A.M. Roque-Afonso, O. Beran, C. Feray, E. Dussaix, D. Samuel, B. Autran, J.C. Duclos-Vallee
Journal: Journal of Hepatology (2007)
TREATMENT OF A CASE OF SCIRRHUS RECURRENT FIVE YEARS IN A PATIENT AGED 93: IMPROVEMENT
Authors: E. A. Peters
Journal: BMJ (1902)

THE X RAYS IS RECURRENT SOIRREUS.LMARCH It 190I left kidney, was a rent in the jejunum, near its commence- ment close to the spine, about x2 inch long in the longitudinal axis of the bowel, at its free border; the edges of this rent were thickened as if bruised; no other source of haemorrhage was discovered.
Personal exposure and long-term health effects in survivors of the union carbide disaster at bhopal.
Authors: V Ramana Dhara, Rosaline Dhara, Sushma D Acquilla, Paul Cullinan
Journal: Environmental Health Perspectives (2002)

Nine years after the Bhopal methyl isocyanate disaster, we examined the effects of exposures among a cross-section of current residents and a subset of those with persistent symptoms. We estimated individual exposures by developing exposure indices based on activity, exposure duration, and distance of residence from the plant. Most people left home after the gas leak by walking and running. About 60% used some form of protection (wet cloth on face, splashing water). Mean and median values of the exposure indices showed a declining trend with increasing distance from the plant. For those subjects reporting any versus no exposure, prevalence ratios were elevated for most respiratory and nonrespiratory symptoms. We examined exposure-response relationships using exposure indices to determine which were associated with health outcomes. The index total exposure weighted for distance was associated with most respiratory symptoms, one measure of pulmonary function in the cross-sectional sample [mid-expiratory flow (FEF)(25-75), p = 0.02], and two measures of pulmonary function in the hospitalized subset [forced expiratory volume (FEV)(1), p = 0.02; FEF(25-75), p = 0.08). Indices that correlated with FEV(1) and forced vital capacity in the hospitalized subset did not correlate with the cross-sectional sample, and most indices (except total exposure) that correlated with the hospitalized subset did not correlate with the cross-sectional sample. Incorporation of distance into every index increased the number of symptoms associated; an improvement was also noted in the strength of the association for respiratory symptoms, but not for pulmonary function. The sum of duration (p = 0.02) and total exposure (p = 0.03) indices independently demonstrated stronger associations with percent predicted FEF(25-75) than the distance variable (p = 0.04). The results show that total exposure weighted for distance has met the criteria for a successful index by being associated with most respiratory symptoms as well as FEF(25-75), features of obstructive airways disease.
Liver Disease: Diagnosis and Management
Authors: Leonard B. Seeff
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes15 August 2000Liver Disease: Diagnosis and ManagementLeonard B. Seeff, MDLeonard B. Seeff, MDNational Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. (Seeff)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-4-200008150-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Bacon BR, Di Bisceglie AM, eds. 512 pages. New York: Churchill Livingstone; 2000. $195.00. ISBN 0443057125. Order phone 800-545-2522.Field of medicine: General internal medicine, gastroenterology, and hepatology.Format: Hardcover book.Audience: Physicians and trainees in primary care, internal medicine, gastroenterology, and hepatology.Purpose: To provide a user-friendly textbook on diagnosis and management of liver disease.Content: The book is divided into four parts: normal hepatic function, evaluation of patients with liver disease, diseases of the liver and biliary tree, and specialized evaluation and treatment of liver and biliary disease. A concise review of the approach to evaluating liver disease ... Author, Article, and Disclosure InformationAffiliations: National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. (Seeff) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 2000Volume 133, Issue 4Page: 316KeywordsAlgorithmsBiliary systemBiopsyGastroenterology and hepatologyLibrariesLiverLiver diseasesRenal diseasesSoftware tools ePublished: 15 August 2000 Issue Published: 15 August 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Mind or mesentery? do the type, frequency and severity of reflux symptoms in patients with coeliac disease and inflammatory bowel disease shed light on their cause?
Authors: S. M. Barratt, J. S. Leeds, K. Robinson, A. J. Lobo, M. E. McAlindon, D. S. Sanders
Journal: Gut (2011)

Working memory performance is significantly influenced by genetic factors. Here, we assessed genetic contributions to both working memory performance and neuroimaging measures focused on the network of brain regions associated with working memory by using a sample of 467 human participants from extended families. Imaging measures included diffusion tensor imaging indices in major white matter tracts thought to be associated with working memory and structural magnetic resonance imaging measures of frontal and parietal gray matter density. Analyses directly addressed whether working memory performance and neural structural integrity are influenced by common genetic factors (e.g., pleiotropy). While all cognitive measures, gray matter regions, and white matter tracts assessed were heritable, only performance on a spatial delayed response task and integrity of the superior longitudinal fasciculus (a primary fronto-parietal connection) shared genetic factors. As working memory may be a core component of other higher level processes, such as general intelligence, this finding has implications for the heritability of complex cognitive functions, as well as for our understanding of the transmission of cognitive deficits in mental and neurological disorders.
CONJUGATE DEVIATION OF THE EYES AND HEAD AND DISORDERS OF THE ASSOCIATED OCULAR MOVEMENTSIN TUMORS AND OTHER LESIONS OF THE CEREBRUM.
Authors: T. H. WEISENBURG
Journal: JAMA (1907)

<h3>VARIOUS VIEWS DISCUSSED.</h3> Within the past two years the causes of conjugate deviation of the eyes and head have repeatedly been the subject of controversy, especially by certain French writers. In 1904, Bard<sup>1</sup>advanced the sensorial theory of conjugate deviation, although this had been spoken of previously by Roux.<sup>2</sup>. This theory has since been ably supported, especially by Dufour,<sup>3</sup>and opposed by Grasset,<sup>4</sup>Dejerine and Roussy,<sup>5</sup>and others. Chiefly through the kindness of Dr. Charles K. Mills and Dr. William G. Spiller I have had the opportunity to study 16 cases of conjugate deviation of the eyes and head, 15 of which are with necropsy, and I have attempted to come to such conclusions as to the causes of conjugate deviation of the eyes and head as the evidence in these cases will permit, together with the aid of cases in the literature. Disorders of
New Locus for Autosomal Dominant Mitral Valve Prolapse on Chromosome 13
Authors: Francesca Nesta, Maire Leyne, Chaim Yosefy, Charles Simpson, Daisy Dai, Jane E. Marshall, Judy Hung, Susan A. Slaugenhaupt, Robert A. Levine
Journal: Circulation (2005)

Background— Mitral valve prolapse (MVP) is a common disorder associated with mitral regurgitation, endocarditis, heart failure, and sudden death. To date, 2 MVP loci have been described, but the defective genes have yet to be discovered. In the present study, we analyzed a large family segregating MVP, and identified a new locus, MMVP3 . This study and others have enabled us to explore mitral valve morphological variations of currently uncertain clinical significance. Methods and Results— Echocardiograms and blood samples were obtained from 43 individuals who were classified by the extent and pattern of displacement. Genotypic analyses were performed with polymorphic microsatellite markers. Evidence of linkage was obtained on chromosome 13q31.3-q32.1, with a peak nonparametric linkage score of 18.41 ( P &lt;0.0007). Multipoint parametric analysis gave a logarithm of odds score of 3.17 at marker D13S132 . Of the 6 related individuals with mitral valve morphologies not meeting diagnostic criteria but resembling fully developed forms, 5 carried all or part of the haplotype linked to MVP. Conclusions— The mapping of a new MVP locus to chromosome 13 confirms the observed genetic heterogeneity and represents an important step toward gene identification. Furthermore, the genetic analysis provides clinical lessons with regard to previously nondiagnostic morphologies. In the familial context, these may represent early expression in gene carriers. Early recognition of gene carriers could potentially enhance the clinical evaluation of patients at risk of full expression, with the ultimate aim of developing interventions to reduce progression.
Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS
Authors: Audrey Filézac de L'Etang, Niran Maharjan, Marisa Cordeiro Braña, Céline Ruegsegger, Ruth Rehmann, Anand Goswami, Andreas Roos, Dirk Troost, Bernard L Schneider, Joachim Weis, Smita Saxena
Journal: Nature Neuroscience (2015)
RETROSPECTIVE STUDY OF PATIENTS HOSPITALIZED FOR ACUTE CORONARY SYNDROME AND UNDERGOING PERCUTANEOUS CORONARY INTERVENTION IN THE UNITED STATES: EXPERIENCE BEFORE, DURING AND AFTER HOSPITALIZATION
Authors: Stephen Johnston, Monika Raut, Donna McMorrow, Concetta Crivera, Jeff Schein, CV Damaraju, Larry Fields
Journal: Journal of the American College of Cardiology (2014)
Altered distribution and synthesis of laminin-5 (kalinin) in oral lichen planus, epithelial dysplasias and squamous cell carcinomas
Authors: T. KAINULAINEN, H. AUTIO-HARMAINEN, A. OIKARINEN, S. SALO, K. TRYGGVASON, T. SALO
Journal: British Journal of Dermatology (1997)

Laminin-5 is a glycoprotein which mediates epithelial cell adhesion to the basement membrane. This study describes the distribution and synthesis of laminin-5 in oral lichen planus, epithelial dysplasias, squamous cell carcinomas and a lymph node metastasis using immunohistochemistry and in situ hybridization. In normal oral mucosa and lichen planus, immunoreaction to the laminin-5 was seen as a thin continuous, delicate line in the basement membrane region, although slight irregularities in the thickness and intensity of the immunoreaction could be detected in some cases with lichen planus. In epithelial dysplasias, the laminin-5 staining was discontinuous and more diffuse compared to lichen planus and normal mucosa. The immunoreaction was generally extracellular, although in some cases with lichen planus and epithelial dysplasia there were a few basal epithelial cells showing cytoplasmic staining. The invasive carcinomas and the lymph node metastasis showed a striking, intense cytoplasmic, staining of the carcinoma cells along the invasive border of the neoplastic islands and in individual infiltrating carcinoma cells. Using in situ hybridization, the laminin-5 gamma 2 chain mRNA expression could not be detected in normal oral mucosa whereas, in non-dysplastic lichen planus and, more strongly, in dysplasias, there was a clear increase in the expression of laminin-5 mRNA in the basal epithelial cells. The most intensive signal was detected in the invasive front of the oral squamous cell carcinomas and the lymph node metastasis. We conclude that, in oral squamous cell carcinoma, there is altered synthesis and secretion of laminin-5 mRNA and protein. It is also evident that in dysplastic lesions of oral epithelium the synthesis and distribution of laminin-5 is abnormal.
Force feeding of mentally competent detainees at Guantanamo Bay
Authors: E. Chrispin, V. Nathanson
Journal: BMJ (2013)

Doctors should resist this violation of human rights and their ethical codes

Protests against the force feeding of mentally competent detainees at the Guantanamo Bay naval base are growing in volume and number. Doctors are increasingly among those expressing concern. This year’s annual representative meeting of the BMA condemned the participation of doctors and nurses in force feeding, branding it a “stain on medical ethics.”1 In doing so, the BMA added its voice to that of the American Medical Association, which denounced the practice in a letter to the secretary of defense of the United States,2 and in a BMJ editorial.3 Individual doctors on both sides of the Atlantic have publicly expressed their alarm.4 5 While the US authorities continue to pursue a medically supervised regime of force feeding, the more insistent the medical community’s protests will become.

The forced enteral feeding of competent adults, protesting at being held without charge, is a human rights issue. The use of doctors and nurses as instruments to violate detainees’ fundamental rights is an issue of both human rights and medical ethics. If the current situation at Guantanamo is a stain on the US authorities’ respect for individual rights, which President Obama acknowledged in a speech he delivered in May,6 it is also a stain on the integrity of the …
The Americans With Disabilities Act
Authors: Victoria L. Thomas, Lawrence O. Gostin
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WARNING—MEDICAL UNIFORMS
Authors: Leonard B. Greentree
Journal: JAMA (1952)

To the Editor:  —On June 16, 1952, a Mr. E. M. Williams, supposedly of 1629 Q Street, N. W., Washington, D. C., came into my office to sell me medical uniforms. I purchased some and gave him a check for $23.85. After waiting a month for delivery, I sent a letter to him at the above address inquiring about the order made. The letter was returned stating that there was no one at that address by that name.  It is quite obvious now that I have been swindled by a smooth talker. This Mr. Williams is an elderly man about 60 years of age, slim, white, and about 5 ft. 5 in. tall. I believe it is only proper that mention of this be made to you so that other physicians will not be swindled in the same manner. I have also notified the Columbus Better Business Bureau.
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain
Authors: Thirumalai R Ramalingam, John T Pesce, Faruk Sheikh, Allen W Cheever, Margaret M Mentink-Kane, Mark S Wilson, Sean Stevens, David M Valenzuela, Andrew J Murphy, George D Yancopoulos, Joseph F Urban, Raymond P Donnelly, Thomas A Wynn
Journal: Nature Immunology (2007)
Bleeding Abdominal Mass in a Patient With Genetic Cutaneous Disorder
Authors: Shawn S. Fu, Jeffrey A. McDavit, Ilia Gur
Journal: JAMA Surgery (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal