Altered Immunologic Activity in Sarcoidosis
Authors: C. E. BUCKLEY
Journal: Annals of Internal Medicine (1966)

Article1 March 1966Altered Immunologic Activity in SarcoidosisC. E. BUCKLEY III, M.D., H. NAGAYA, M.D., HEBERT O. SIEKER, M.D., F.A.C.P.C. E. BUCKLEY III, M.D.Search for more papers by this author, H. NAGAYA, M.D.Search for more papers by this author, HEBERT O. SIEKER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-508 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe etiology and pathogenesis of sarcoidosis is unknown. Past attempts to demonstrate specific etiologic agents have met with little success. The concept that sarcoidosis occurs only in association with an unusual kind of immunologic responsiveness is not new (1). Many studies of the immunologic response of patients to a variety of agents (2-12) have followed Pinner's (13) suggestion that sarcoid is an anergic form of tuberculosis. Despite demonstrable anergy to tuberculoprotein and other agents that normally provoke delayed hypersensitivity, serologic activity to the same (10) and other antigens often remains intact or hyperactive in patients with sarcoidosis. Various etiologic possibilities...References1. SILTZBACH LE: Editorial: Progress in sarcoidosis. Amer. J. Med. 22: 841, 1957. CrossrefMedlineGoogle Scholar2. NITTER L: Changes in the chest roentgenogram in Boeck's sarcoid of the lung. Acta. Radiol. (Stockholm) (Supplement) 105: 1, 1953. Google Scholar3. JAMESPEPYS DGJ: Tuberculin in aqueous and oily solutions: skin test reactions in normal subjects and in patients with sarcoidosis. Lancet 1: 602, 1956. CrossrefGoogle Scholar4. PEPYS J: The relationship of non-specific and specific factors in the tuberculin reaction. Amer. Rev. Tuberc. 71: 49, 1955. Google Scholar5. SONESISRAEL MHL: Altered immunologic reactions in sarcoidosis. Ann. Intern. Med. 40: 260, 1954. LinkGoogle Scholar6. ISRAELSONESSTEINARONSON HLMSCJD: BCG vaccination in sarcoidosis. Amer. Rev. Tuberc. 62: 408, 1950. Google Scholar7. FRIOU GJ: A study of the cutaneous reactions to oidiomycin, trichophytin, and mumps skin test antigens in patients with sarcoidosis. Yale J. Biol. Med. 24: 533, 1952. MedlineGoogle Scholar8. URBACHSONESISRAEL FMHL: Passive transfer of tuberculin sensitivity to patients with sarcoidosis. New Eng. J. Med. 247: 794, 1952. CrossrefMedlineGoogle Scholar9. QUINNBUNCHYAGLE ELDCEM: The mumps skin test and complement fixation test as a diagnostic aid in sarcoidosis. J. Invest. Derm. 24: 595, 1955. CrossrefMedlineGoogle Scholar10. SANDSPALMERMAYOCKCREGER JHPPRLWP: Evidence for serologic hyper-reactivity in sarcoidosis. Amer. J. Med. 19: 401, 1955. CrossrefMedlineGoogle Scholar11. EPSTEINMAYOCK WLRL: Induction of allergic contact dermatitis in patients with sarcoidosis. Proc. Soc. Exp. Biol. Med. 96: 786, 1957. CrossrefMedlineGoogle Scholar12. LOFGREN S: Immunological and aetiological aspects of sarcoidosis. Acta. Tuberc. Scand. (Supplement) 45: 19, 1959. Google Scholar13. PINNER M: Editorial: On the etiology of sarcoidosis. Amer. Rev. Tuberc. 54: 582, 1946. Google Scholar14. REFVEM O: The pathogenesis of Boeck's disease. Acta. Med. Scand. (Supplement) 294: 1, 1954. Google Scholar15. SILTZBACH LE: Editorial: Current thoughts on the epidemiology and etiology of sarcoidosis. Amer. J. Med. 39: 361, 1965. CrossrefMedlineGoogle Scholar16. NETHERSCOTTSTRAWBRIDGE SEWG: Identification of bacterial residues in sarcoid lesions. Lancet 2: 1132, 1956. CrossrefGoogle Scholar17. WORK E: Correspondence. Identification of bacterial residues in sarcoid lesions. Ibid., p. 1310. Google Scholar18. CUMMINSHARRIS CSH: Correspondence. Identification of bacterial residues in sarcoid lesions. Lancet 1: 106, 1957. Google Scholar19. CONSDEN R: Correspondence. Identification of bacterial residues in sarcoid lesions. Ibid., p. 106. Google Scholar20. BERG JW: Correspondence. Identification of bacterial residues in sarcoid lesions. Ibid., p. 272. Google Scholar21. MICHAELCOLEBEESONOLSON MRMPBBJ: Sarcoidosis. Preliminary report on study of 350 cases with special reference to epidemiology. Amer. Rev. Tuberc. 62: 403, 1950. Google Scholar22. CUMMINGSDUNNERWILLIAMS MMEJH: Epidemiologic and clinical observations in sarcoidosis. Ann. Intern. Med. 50: 879, 1959. LinkGoogle Scholar23. TEILUM G: Allergic hyperglobulinosis and hyalinosis (paramyloidosis) in the reticuloendothelial system in Boeck's sarcoid and other conditions. Amer. J. Path. 24: 389, 1948. MedlineGoogle Scholar24. SCADDING JG: Mycobacterium tuberculosis in the aetiology of sarcoidosis. Brit. Med. J. 2: 1617, 1960. CrossrefMedlineGoogle Scholar25. BERNARDOWENS LAJC: Isolated cryptococcosis associated with Boeck's sarcoid. Report of a case treated with amphotericin B. Arch. Intern. Med. (Chicago) 106: 101, 1960. CrossrefMedlineGoogle Scholar26. CHAPMAN JS: Mycobacterial and mycotic antibodies in sera of patients with sarcoidosis. Results of studies using agar double-diffusion technique. Ann. Intern. Med. 55: 918, 1961. LinkGoogle Scholar27. MANKIEWICZ E: The relationship of sarcoidosis to anonymous bacteria. Acta. Med. Scand. (Supplement) 176: 68, 1964. Google Scholar28. TURKINGTONBUCKLEY RWCE: Macrocryoglobulinemia and sarcoidosis. Amer. J. Med. 40: 156, 1966. CrossrefMedlineGoogle Scholar29. SCHEIDEGGER JJ: Une micro-methode de l'immuno-electrophorese. Int. Arch. Allerg. 7: 103, 1955. CrossrefGoogle Scholar30. BACHHIRSCHHORN FK: Lymphocyte interaction: a potential histocompatibility test in vitro. Science 143: 813, 1964. CrossrefMedlineGoogle Scholar31. KABATMAYER EAMM: Experimental Immunochemistry. Charles C Thomas, Publisher, Springfield, Ill., 1961, p. 133. Google Scholar32. MATHER K: Statistical Analysis in Biology. Interscience Publishers, New York, 1947. CrossrefGoogle Scholar33. MULLER-EBERHARDNILSSON HJU: Relation of a β1-glycoprotein of human serum to the complement system. J. Exp. Med. 111: 217, 1960. CrossrefMedlineGoogle Scholar34. HORNUNGARQUEMBOURG MRC: βIC-globulin: an "acute phase" serum reactant of human serum. J. Immun. 94: 307, 1965. MedlineGoogle Scholar35. SALTZMANCHICKCONANT HAEWNF: Nocardiosis as a complication of other diseases. Lab. Invest. 11: 1110, 1962. MedlineGoogle Scholar36. RUSSELL WJ: An analysis of certain factors related to the quantitation of immunoelectrophoresis. J. Immun. 94: 942, 1965. MedlineGoogle Scholar37. MAYOCKBERTRANDMORRISONSCOTT RLPCEJH: Manifestations of sarcoidosis. Analysis of 145 patients, with a review of nine series selected from the literature. Amer. J. Med. 35: 67, 1963. CrossrefMedlineGoogle Scholar38. GREENBERGJAMESFEIZIBIRD GDGTR: Serum proteins in sarcoidosis. Lancet 2: 1313, 1964. CrossrefMedlineGoogle Scholar39. HIRSCHHORNSCHREIBMANBACHSILTZBACH KRRFHLE: In vitro studies of lymphocytes from patients with sarcoidosis and lymphoproliferative diseases. Ibid., p. 842. Google Scholar40. MARSHALLROBERTS WHKB: Tuberculin induced-mitosis in peripheral blood leukocytes. Lancet 1: 773, 1963. CrossrefMedlineGoogle Scholar41. BERNARDGERALDESBOIRON CAM: Effects of phytohaemagglutinin on blood cultures of chronic lymphocytic leukaemias. Lancet 1: 667, 1964. CrossrefMedlineGoogle Scholar42. STARRBERKOVICH SS: Effects of measles, gamma-globulin modified measles and vaccine measles on the tuberculin test. New Eng. J. Med. 270: 386, 1964. CrossrefMedlineGoogle Scholar43. GRESSER I: Production of interferon by suspensions of human leukocytes. Proc. Soc. Exp. Biol. Med. 108: 799, 1961. CrossrefMedlineGoogle Scholar44. LEEOZERE SHRL: Production of interferon by human mononuclear leukocytes. Proc. Soc. Exp. Biol. Med. 118: 190, 1965. CrossrefMedlineGoogle Scholar45. WHEELOCK EF: Interferon-like virus inhibitor induced in human leukocytes by phytohemagglutinin. Science 149: 310, 1965. CrossrefGoogle Scholar46. SIMONSEN M: Biological incompatibility in kidney transplantation in dogs. II. Serologic investigations. Acta. Path. Microbiol. Scand. 32: 36, 1953. CrossrefGoogle Scholar47. MANKIEWICZVAN WALBEEK EM: Mycobacteriophages. Their role in tuberculosis and sarcoidosis. Arch. Environ. Health (Chicago) 5: 122, 1962. CrossrefMedlineGoogle Scholar48. NORBERG R: Studies in sarcoidosis. I. Serum proteins. Acta. Med. Scand. 175: 359, 1964. CrossrefMedlineGoogle Scholar49. UHRFINKELSTEIN JWMS: Antibody formation. IV. Formation of rapidly and slowly sedimenting antibodies and immunologic memory to bacteriophage Phi-X 174. J. Exp. Med. 117: 457, 1963. CrossrefMedlineGoogle Scholar50. WESTHONGHOLLAND CDRND: Immunoglobulin levels from the newborn period to adulthood and in immunoglobulin deficiency states. J. Clin. Invest. 41: 2054, 1962. CrossrefMedlineGoogle Scholar51. SAHAIRSCHWARTZ KRS: The immunoglobulin sequence. I. Arrest by 6-mercaptopurine and restitution by antibody, antigen, or splenectomy. J. Immun. 95: 345, 1965. MedlineGoogle Scholar52. SWIFT J: A rapsody, in On Poetry, Dublin-London, 1733. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North CarolinaFrom the Allergy Division of the Department of Medicine and the Immunology Division of the Department of Microbiology and Immunology, Duke University Medical Center, Durham, N. C.This study was supported in part by grants 5TI-AI-31-08 and HE-04807, U. S. Public Health Service, Bethesda, Md., and the North Carolina Tuberculosis Association.Dr. Buckley is a Research Career Development Awardee, National Institute of Allergy and Infectious Disease (grant 5-K3-AI, 14, 797,-05), National Institutes of Health, Bethesda, Md.This paper was presented at a meeting of the American Federation for Clinical Research, May 2, 1965, Atlantic City, N. J.Requests for reprints should be addressed to C. E. Buckley, III, M.D., Duke University Medical Center, Durham, N. C. 27706. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByElevated serum BAFF levels in patients with sarcoidosis: association with disease activityThalidomide Induces Granuloma Differentiation in Sarcoid Skin Lesions Associated with Disease ImprovementIMMUNOLOGY OF SARCOIDOSISInhibition of Interferon Gamma Production by Peripheral Blood Mononuclear Leukocytes of Patients with SarcoidosisSarcoid and cytotoxic lung antibodiesElevated Serum Immunoglobulin G Levels and Bronchoalveolar Lymphocytosis as Predictors of Clinical Course in Pulmonary SarcoidosisPulmonary SarcoidosisInteraction of immune complexes and T suppressor cells in sarcoidosis.Comparison of the Manifestations of Acute Sarcoid Arthritis with and Without Erythema Nodosum: Immunopathogenic SignificanceHistiocytic lymphoma following resolution of sarcoidosisSarcoidosisRelationship between peripheral blood lymphocytes and their functional capacity in sarcoidosisImmunologic Abnormalities in SarcoidosisRONALD P. DANIELE, M.D., JAMES H. DAUBER, M.D., MILTON D. ROSSMAN, M.D.Serum-migration inhibitory activity in patients with sarcoidosisSuppressor Cell Function in SarcoidosisJAMES S. GOODWIN, M.D., RAPHAEL DeHORATIUS, M.D., HAROLD ISRAEL, M.D., GLENN T. PEAKE, M.D., RONALD P. MESSNER, M.D.The treatment of sarcoidosis by levamisoleSarkoidoseSarcoidosis and selective IgA deficiencyCorrelation of delayed hypersensitivity and leukocyte migration inhibition factor in the serum of cancer patientsLymphocyte Subpopulations in Sarcoidosis: Correlation with Disease Activity and DurationRONALD P. DANIELE, M.D., DAVID T. ROWLANDS Jr., M.D.Lymphokines (MIF) in the serum of patients with sarcoidosis and cutaneous granuloma annulareSARCOID LYMPHOCYTES: B- AND T-CELL QUANTITATIONDISTRIBUTION AND FUNCTION OF T- AND B-CELL SUBPOPULATIONS IN SARCOIDOSISANTIBODIES TO T CELLS IN SARCOIDOSISIMMUNOLOGICAL IDENTIFICATION OF SUBPOPULATIONS OF MONONUCLEAR CELLS IN SARCOID GRANULOMASKINETICS OF MONOCYTE RECEPTOR ACTIVITY FOR IMMUNOPROTEINS IN PATIENTS WITH SARCOIDOSISLeukotactic Dysfunction in SarcoidosisEUFRONIO G. MADERAZO, M.D., PETER A. WARD, M.D., CHARLES L. WORONICK, Ph.D., JOAN KUBIK, M.A., ARTHUR C. DeGRAFF Jr., M.D.Phytohaemagglutinin and transfer factor in the leucocyte migration inhibition test in patients with sarcoidosis.Immunology of sarcoidosisImmunity and Allergy in SarcoidosisCORRELATION OF PHYTOHAEMAGGLUTININ-INDUCED LYMPHOCYTE TRANSFORMATION WITH CLINICAL MANIFESTATIONS OF SARCOIDOSIS*The significance of Candida albicans in denture stomatitisRegional Enteritis and Sarcoidosis in One PatientLYMPHOCYTE RESPONSE IN SARCOIDOSISMonocyte Receptor Activity in Normal Individuals and Patients with SarcoidosisImmunological studies in a patient with ulcerative colitis and sarcoidosisA Correlation of in Vivo Delayed-Type Hypersensitivity with in Vitro Lymphocyte Transformation in SarcoidosisA Comparison of Serum Immunoglobulin Concentrations in Sarcoidosis and TuberculosisC. E. BUCKLEY III, M.D., F. C. DORSEY, M.A.CELL-MEDIATED IMMUNITY: IN VITRO STUDIESAnergy, dysimmunoglobulinemia, and unexplained inflammation. A new therapeutic approach with a chemically defined dietPositive Antinuclear Factor in Patients with Unexplained Pulmonary FibrosisHIROSHI NAGAYA, M.D., C. EDWARD BUCKLEY III, M.D., HERBERT O. SIEKER, M.D., F.A.C.P.LYMPHOCYTE STIMULATION WITH PHYTOHÆMAGGLUTININ IN MULTIPLE SCLEROSISCANNABIS AND CHROMOSOMESImmunologic Reactivity in Patients with LeprosyJOHN N. SHEAGREN, M.D., JEROME B. BLOCK, M.D., F.A.C.P., JOHN R. TRAUTMAN, M.D., SHELDON M. WOLFF, M.D., F.A.C.P.Zur Pathophysiologie und Klinik des KomplementsSarcoidosis in childrenThe Wiskott-Aldrich Syndrome Immunopathologic Mechanisms and a Long-Term SurvivalM. A. J. MANDL, M.B., J. I. WATSON, M.D., F.R.C.P.(C), B. ROSE, M.D., PH.D., F.A.C.P.Alterations in human serum β1C-globulin (C′3) in renal transplantationCryoglobulins, rheumatoid factors and connective tissue disordersMacroglobulinemia and vasculitis in Sjögren's syndromeStudies in SarcoidosisOccasional Survey 1 March 1966Volume 64, Issue 3Page: 508-520KeywordsAllergy and immunologyCareers in researchHyperglobulinemiaHypersensitivityImmunologyInfectious diseasesMedical servicesMicrobiologyPathogenesisSarcoidosis Issue Published: 1 March 1966 PDF DownloadLoading ...