Enoxaparin-Induced Skin Necrosis
Authors: Moshe Fried
Journal: Annals of Internal Medicine (1996)

Letters15 September 1996Enoxaparin-Induced Skin NecrosisMoshe Fried, MD, Sraya Kahanovich, MD, and Rephael Dagan (Reiss), MDMoshe Fried, MDMeir General Hospital, 44281 Kfar-Saba, Israel, Sraya Kahanovich, MDMeir General Hospital, 44281 Kfar-Saba, Israel, and Rephael Dagan (Reiss), MDMeir General Hospital, 44281 Kfar-Saba, IsraelAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-6-199609150-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Enoxaparin, a low-molecular-weight heparin used to treat and prevent deep venous thrombosis, has been evaluated in several clinical trials [1, 2]. The wide use of the drug makes it imperative that possible side effects, including skin reactions, be studied [3, 4]. We report the rare occurrence of skin necrosis that developed after enoxaparin administration. To our knowledge, previous reports of side effects of enoxaparin have described local skin inflammation and pruritis, but not necrosis. One report [5] noted that a different low-molecular-weight heparin caused skin necrosis. We surveyed approximately 8000 subcutaneous injections of enoxaparin (40 mg once ...References1. Noble S, Peters DH, Goa KL. Enoxaparin: a reappraisal of its pharmacology and clinical applications in the prevention and treatment of thromboembolic disease. Drugs. 1995; 49:388-410. Google Scholar2. Spiro TE, Johnson GJ, Christie MJ, Lyons RM, MacFarlane DE, Blasier RB, et al. Efficacy and safety of enoxaparin to prevent deep venous thrombosis after hip replacement surgery. Ann Intern Med. 1994; 121:81-9. Google Scholar3. Manoharan A. Heparin-induced skin reaction with low-molecular-weight heparin. Eur J Haematol. 1992; 48:234. Google Scholar4. Phillips JK, Majumdar G, Hunt BJ, Savidge GF. Heparin-induced skin reaction due to two different preparations of low molecular weight heparin (LMWH). Br J Haematol. 1993; 84:349-50. Google Scholar5. Ojeda E, del Carmen Percz M, Mataix R, et al. Skin necrosis with low molecular weight heparin. Br J Haematol. 1992; 82:620. Google Scholar Author, Article, and Disclosure InformationAuthors: Moshe Fried, MD; Sraya Kahanovich, MD; Rephael Dagan (Reiss), MDAffiliations: Meir General Hospital, 44281 Kfar-Saba, Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRare presentation of enoxaparin-induced skin necrosis in a postoperative patientBleeding, Heparin-induced thrombocytopenia, and Other adverse reactionsHeparinsAbdominal Skin Necrosis after Enoxaparin TreatmentNecrosis cutánea por heparinaWarfarin-induced skin necrosisANTICOAGULANTS, THROMBOLYTIC AGENTS, AND ANTI-PLATELET DRUGSNécrose cutanée et thrombocytose induites par la nadroparine en réanimation: un diagnostic inhabituelHeparinsVasculite cutanée à IgA induite par héparine de bas poids moléculaireLow molecular weight heparin-induced skin necrosis—a systematic reviewAnaphylactoid Reaction to Enoxaparin in a Patient with Deep Venous ThrombosisIT FITS! (Intelligence Transfer: From Images to Solutions) Massive Abdominal Ecchymosis and Hematoma Due to Local Injection of EnoxaparinEnoxaparin-Associated Dermal Necrosis: A Consequence of Cross-Reactivity with Heparin-Mediated AntibodiesEnoxaparin sodium 15 September 1996Volume 125, Issue 6 Page: 521-522 Keywords Biopsy Deep vein thrombosis Drugs Low molecular weight heparin Necrosis Skin reaction Subcutaneous injections Surgery Uterus Vasculitis ePublished: 15 August 2000 Issue Published: 15 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...