tbuckley/cabot-search huggingface dataset:
Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron
Authors: V Visconte, N Avishai, R Mahfouz, A Tabarroki, J Cowen, R Sharghi-Moshtaghin, M Hitomi, H J Rogers, E Hasrouni, J Phillips, M A Sekeres, A H Heuer, Y Saunthararajah, J Barnard, R V Tiu
Journal: Leukemia (2014)
Clinical Efficacy and Morbidity Associated with Continuous Cyclic Compared with Continuous Ambulatory Peritoneal Dialysis
Authors: Carola W. H. de Fijter
Journal: Annals of Internal Medicine (1994)

Objective: To assess the clinical efficacy and morbidity of continuous cyclic peritoneal dialysis compared with continuous ambulatory peritoneal dialysis with a Y-connector as renal replacement therapy. Design: Prospective, randomized study. Setting: University hospital. Patients: All new patients with end-stage renal failure consecutively entering the dialysis program from January 1988 through July 1991 were randomly assigned to receive continuous ambulatory peritoneal dialysis with a Y-connector or continuous cyclic peritoneal dialysis and were followed prospectively. Measurements: Patient and technique survival, dialysis adequacy, and (infectious) morbidity. Results: Forty-one patients (median age, 56 years; range, 18 to 86 years) started continuous ambulatory peritoneal dialysis with a Y-connector (follow-up, 688 patient-months), and 41 patients (median age, 54 years; range 21 to 76 years) started continuous cyclic peritoneal dialysis (follow-up, 723 patient-months). The two groups showed no significant differences in adequacy of dialysis (as assessed by blood pressure control and laboratory and neurologic variables) and patient or technique survival. Renal transplant was the primary reason for discontinuing the assigned dialysis technique in both groups. The average number of hospitalizations per patient-year was 1.0 using continuous ambulatory peritoneal dialysis with a Y-connector and 0.6 per patient-year using continuous cyclic peritoneal dialysis (P = 0.02), with a mean duration of 10.8 and 9.6 days per admission, respectively (not significant). Peritonitis occurred significantly less often in those receiving continuous cyclic peritoneal dialysis (0.94 compared with 0.51 episodes per patient-year; P = 0.03). No difference in causative pathogens was observed. Exit site infection rate was 0.38 episodes per patient-year in both groups. Conclusion: In an unselected patient group, continuous cyclic peritoneal dialysis was accompanied by significantly lower rates of peritonitis and dialysis-related hospital admission, whereas it was as effective as continuous ambulatory peritoneal dialysis with a Y-connector for patient and technique survival.
Serum eosinophil cationic protein (ECP) as a marker of disease activity and treatment efficacy in seasonal asthmi
Authors: A. Vatrella, A. Ponticiello, R. Parrella, I. Romano, S. Zofra, A. Di Leva, F. Bariffi
Journal: Allergy (1996)

This study was carried out to determine whether serum cosinophil cationic protein (ECP) represents a sensitive marker for disease activity in atopic asthmatic patients during the pollen season. The study. in double‐blind fashion, was performed between February and June 1994. Two groups of 10 seasonal asthmatic patients randomly received two different treatments. The first group was treated with inhaled beclomethasone dipropionate (BDP) 500 kg bid; the second received a matched placebo (P). At the beginning and every month, blood samples for determination of ECP and eosinophil count were collected and lung function (FEV 1 ) and methacholine responsiveness (PD 20 ) were performed. Subjects recorded daily symptoms of asthma, salbutamol consumption, and peak expiratory flow (PEF) values. In the P group, all indices, except FEV 1 , showed significant changes during the pollen season (P&lt; 0.001). In the BDP group, significant changes were detected for symptom score (P&lt;0.01). salbutamol consumption (P&lt;0.01), and eosinophil number (P&lt;0.05). Between the two groups, significant differences for symptom score (P&lt;0.001), salbutamol consumption (P&lt; 0.001), ECP levels (P&lt;0.05), eosinophil count (P&lt;0.02), PD 20 methacholine (P&lt;0.02), and PEF values (P&lt;0.01) were detected. Changes in serum ECP significantly correlated with changes in other parameters (P&lt; 0.001), except FEV 1 . Our results provide evidence that serum ECP is a sensitive marker for monitoring of the disease activity in seasonal asthma. Furthermore, it may offer a useful tool for estimating treatment efficacy.
Digitoxin treatment and experimental cardiac hypertrophy in the rat
Authors: H. TURTO, S. LINDY
Journal: Cardiovascular Research (1973)

Cardiac hypertrophy was produced in rats by constricting the abdominal aorta. When the animals were digitalized before the operation the development of cardiac hypertrophy, as well as the increase in the content and labelling of myocardial proteins, could be prevented. However, in spite of treatment with digitoxin a significant increase both in the content and labelling of myocardial RNA was seen in animals with constriction of the aorta. The results indicate that as digitoxin treatment prevents the cardiac hypertrophy it interferes with protein synthesis through a mechanism which has smaller effects on RNA synthesis.
Reinventing continuing medical education
Authors: Carolyn Clancy
Journal: BMJ (2004)

In 2003, two significant reports confirmed large gaps in the quality of American health care. McGlynn found that Americans receive recommended services only 54.9% of the time, and the first National Healthcare Quality Report demonstrated a similar “chasm” between evidence-based and actual care.1,2 Both reports confirmed that the gaps in delivery of evidence-based preventive services are comparable in size to those in delivery of other services. Sadly enough, this is old news. Questions prompted by these and other …
Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence
Authors: Christoph Wasem, Diana Arnold, Leslie Saurer, Nadia Corazza, Sabine Jakob, Simon Herren, Claudio Vallan, Christoph Mueller, Thomas Brunner
Journal: Journal of Clinical Investigation (2003)

Death receptor–mediated activation-induced apoptosis of antigen-specific T cells is a major mechanism of peripheral tolerance induction and immune homeostasis. Failure to undergo activation-induced cell death (AICD) is an important underlying cause of many autoimmune diseases. Thus, enhancing the T cell's own suicide mechanism may provide an efficient therapy for the treatment of autoimmune diseases. Bisindolylmaleimide VIII (Bis VIII), a PKC inhibitor, can sensitize T cells for death receptor–induced apoptosis and thus can inhibit the development of T cell–mediated autoimmune disease in vivo. In this study, we have analyzed the functional consequences of accelerated suicide for a protective CD8+ T cell–mediated immune response. Our data indicate that CD8+ T cells are sensitized by Bis VIII to AICD, both in vitro and in vivo. The sensitizing effect of Bis VIII appears to be mediated by specific downmodulation of the antiapoptotic molecule cellular FLICE-like inhibitory protein (cFLIPL). Importantly, Bis VIII administration during an acute lymphocytic choriomeningitis virus (LCMV) infection causes the depletion of virus-specific CD8+ T cells and subsequently impaired cytotoxicity and virus clearance. We conclude that resistance to death receptor–induced apoptosis is crucial for the efficient induction of a protective immune response, and that Bis VIII–based immunotherapies have to be applied under well-controlled conditions to avoid the induction of immune incompetence and the inability to respond to pathogen infection.
Sunscreens block the induction of epidermal ornithine decarboxylase by ultraviolet-B radiation: a new way of evaluating sunscreen efficacy in vivo
Authors: R.W. GANGE, R. MENDELSON
Journal: British Journal of Dermatology (1982)

Two proprietary sunscreen preparations containing para-aminobenzoic acid and sulisobenzone, respectively, were tested for their ability to block the induction of ornithine decarboxylase by medium wavelength ultraviolet radiation (UV-B) in the epidermis of the hairless mouse. Both preparations were effective, the sunscreen treated animals requiring more radiation for ornithine decarboxylase induction. The UV dose-response gradients were reduced by a mean factor of 7–35 (sulisobenzone) and 15 (PABA). These figures correlate well with other in vivo sunscreen assays. This new method provides a simple and reproducible way of evaluating sunscreens in vivo.
Permanent engraftment and function of hepatocytes delivered to the liver: Implications for gene therapy and Liver Repopulation
Authors: Sanjeev Gupta, Emma Aragona, Ravikumar P. Vemuru, Kuldeep K. Bhargava, Robert D. Burk, Jayanta Roy Chowdhury
Journal: Hepatology (1991)

To examine the distribution of intrasplenically transplanted hepatocytes, we used HBsAg-producing G7 HBV transgenic hepatocytes or cells labeled with 111In. Most hepatocytes translocated to the liver (55% +/- 7%; mean +/- S.D.); the spleen retained a smaller fraction (15% +/- 3%); and some transplanted cells localized in lungs (3%) or pancreas (1%). Transplanted hepatocytes were rapidly assimilated into the liver lobule. Morphometrical quantitation indicated that the numbers of transplanted hepatocytes in the liver at 48 hr and at 9 mo after transplantation were similar. Serum HBsAg was detected in recipients of the G7 HBV hepatocytes during the 1-yr experiment. These results indicate that a large number of hepatocytes can be reproducibly delivered to the liver by transplantation into the spleen. Transplanted hepatocytes engraft rapidly, assimilate into host liver, maintain normal function and survive permanently. Systems for safe delivery and localization of hepatocytes in the liver represent a critical step toward successfully accomplishing hepatocyte-directed gene therapy and repopulation of the acutely devastated liver.
Abstract 3133: The anti-tumor effects of acetazolamide and sulforaphane on bronchial carcinoids: Preclinical modeling and mechanism
Authors: Reza Bayat Mokhtari, Syed S. Islam, Narges Baluch, Karen Aitken, Sushil Kumar, Hai-Ling Margaret Cheng, Mehrdad Yazdanpanah, Khosrow Adeli, Yuanxiang Zhou, Ernest Cutz, Herman Yeger
Journal: Cancer Research (2014)

Abstract Background: The prognosis of patients with metastatic bronchial carcinoid remains poor despite current conventional and targeted therapies. Here we evaluated the therapeutic potential of acetazolamide (AZ; a pan carbonic anhydrase inhibitor affecting pH regulation and homeostasis) and sulforaphane (SFN; a natural isothiocyanate compound targeting multiple pathways in cancer cells), for their anti-cancer properties. Methods: In vitro and in vivo studies were conducted on H-727 (typical carcinoid) and H-720 (atypical carcinoid) bronchial carcinoid cell lines. We developed a lung orthotopic bronchial carcinoid tumor xenograft model in NOD/SCID mice. Results: AZ and/or SFN significantly inhibited cell viability and clonogenic capacity in a dose-dependent manner (0-80 μM, 48 hours and 7 days). AZ and/or SFN downregulated phosphoH3, Ki67, EPCAM, CA9, Akt1 and upregulated p21 and Nrf2 proteins compared to controls as confirmed by Western blot. Upregulation of Nrf2 gene expression was confirmed by qPCR. AZ and/or SFN significantly reduced xenograft growth and serotonin content after two weeks treatment. In the lung orthotopic model, MR imaging at 3 Tesla precisely identified growth of H-727 injected cells in the ipsilateral side, and revealed liver metastasis as confirmed by histology. A tumor initiating cell (TIC) fraction isolated under stem cell culture conditions showing significantly enhanced tumorigenicity was also studied. Conclusions: AZ and/or SFN inhibited tumor survival, proliferation, invasiveness, serotonin secretion and tumorigenic potential of bronchial carcinoid cell lines. Since the combination of AZ+SFN was more effective than either single agent, we postulate that AZ potentiates the effects of SFN by inhibiting PI3K/AKT, which could enhance the inhibitory effect of SFN on P21, Ki67 and phosphoH3. Interestingly, Nrf2 upregulation by both AZ and by SFN suggested a potent antioxidant response. The lung orthotopic tumor model of bronchial carcinoids permits study of carcinoid metastatic progression. As the doses used in this study are clinically bioavailable we suggest that AZ and SFN may have promising potential for carcinoid therapy and resolution of the carcinoid syndrome. Citation Format: Reza Bayat Mokhtari, Syed S. Islam, Narges Baluch, Karen Aitken, Sushil Kumar, Hai-Ling Margaret Cheng, Mehrdad Yazdanpanah, Khosrow Adeli, Yuanxiang Zhou, Ernest Cutz, Herman Yeger. The anti-tumor effects of acetazolamide and sulforaphane on bronchial carcinoids: Preclinical modeling and mechanism. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3133. doi:10.1158/1538-7445.AM2014-3133
Endogenous adenosine, A1 adenosine receptor, and pertussis toxin sensitive guanine nucleotide binding protein mediate hypoxia induced AV nodal conduction block in guinea pig heart in vivo
Authors: J. Xu, H. Tong, L. Wang, C. M Hurt, A. Pelleg
Journal: Cardiovascular Research (1993)

Journal Article Endogenous adenosine, A1 adenosine receptor, and pertussis toxin sensitive guanine nucleotide binding protein mediate hypoxia induced AV nodal conduction block in guinea pig heart in vivo Get access Jiang Xu, Jiang Xu Likoff Cardiovascular Institute, Hahnemann University, Mail Stop 110, Broad and Vine Streets, Philadelphia, PA 19102-1192, USA: J Xu, H Tong, L Wang, C M Hurt, A Pelleg. Correspondence to Professor Pelleg. Search for other works by this author on: Oxford Academic PubMed Google Scholar He Tong, He Tong Likoff Cardiovascular Institute, Hahnemann University, Mail Stop 110, Broad and Vine Streets, Philadelphia, PA 19102-1192, USA: J Xu, H Tong, L Wang, C M Hurt, A Pelleg. Correspondence to Professor Pelleg. Search for other works by this author on: Oxford Academic PubMed Google Scholar Li Wang, Li Wang Likoff Cardiovascular Institute, Hahnemann University, Mail Stop 110, Broad and Vine Streets, Philadelphia, PA 19102-1192, USA: J Xu, H Tong, L Wang, C M Hurt, A Pelleg. Correspondence to Professor Pelleg. Search for other works by this author on: Oxford Academic PubMed Google Scholar Carl M Hurt, Carl M Hurt Likoff Cardiovascular Institute, Hahnemann University, Mail Stop 110, Broad and Vine Streets, Philadelphia, PA 19102-1192, USA: J Xu, H Tong, L Wang, C M Hurt, A Pelleg. Correspondence to Professor Pelleg. Search for other works by this author on: Oxford Academic PubMed Google Scholar Amir Pelleg Amir Pelleg Likoff Cardiovascular Institute, Hahnemann University, Mail Stop 110, Broad and Vine Streets, Philadelphia, PA 19102-1192, USA: J Xu, H Tong, L Wang, C M Hurt, A Pelleg. Correspondence to Professor Pelleg. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 1, January 1993, Pages 134–140, https://doi.org/10.1093/cvr/27.1.134 Published: 01 January 1993 Article history Received: 03 February 1992 Accepted: 09 April 1992 Published: 01 January 1993
Local side‐effects of inhaled corticosteroids in asthmatic children: influence of drug, dose, age, and device
Authors: J. C. Dubus, C. Marguet, A. Deschildre, L. Mely, P. Le Roux, J. Brouard, L. Huiart
Journal: Allergy (2001)

The objective was to investigate the local side-effects of inhaled corticosteroids (ICS) in daily life in asthmatic children, particularly the younger ones, by an observational prospective cross-sectional cohort study.Asthmatic children (n=639, 75.9+/-48.9 months, 61.3% boys), treated with beclomethasone dipropionate (BDP) (721.0+/-287.3 microg per day) or budesonide (BUD) (835.5+/-684.9 microg per day) for at least 1 month, were recruited at the time of a scheduled visit. Local side-effects were researched by questionnaire (cough during inhalation, hoarseness, dysphonia, and thirsty feeling) and clinical examination (perioral dermatitis, oral candidiasis, and tongue hypertrophy).Exactly 63.3% of the children aged under 6 years and 59.5% of the older ones reported one local side-effect. Cough (39.7%) was dependent on young age, use of BDP, and mainly use of spacer device, with an OR of 4.7 (95% CI: 2.7-8.2). Thirsty feeling (21.9%) and hoarseness (14.1%) occurred in children using ICS and long-acting beta2-agonists. Dysphonia (11.1%) was favored by high doses of BDP and BUD, and by inhalation from spacer devices or nebulizers. No factor favored oral candidiasis (10.7%). Perioral dermatitis (2.9%) and tongue hypertrophy (0.1%) were associated with nebulization.Local side-effects of ICS are common in asthmatic children of all ages, and the device used constitutes the most influential factor.
NEUROSPECT FINDINGS IN PATIENTS (PTS) EXPOSED TO NEUROTOXIC CHEMICALS
Authors: G Heuser, I Mena, J Goldstein, C Thomas, F Alamos
Journal: Clinical Nuclear Medicine (1993)

NEUROSPECT FINDINGS IN PATIENTS (PTS) EXPOSED TO NEUROTOXIC CHEMICALS  G Heuser;I Mena;J Goldstein;C Thomas;F Alamos; Clinical Nuclear Medicine
Irradiation of Meat Approved for Pathogen Control
Authors: Stuart L. Nightingale
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-589 Reaching Further in the Treatment of Calcified Small Vessel Disease - is Rota-DEB an Option?
Authors: Paula Mota, Rita Calé, Hélder Pereira, Manuel Almeida, Mário Camacho, Ernesto Pereira, Marco Costa, Rui Teles, Cristina Martins, José Baptista, Hugo Vinhas, Dinis Martins, António Leitão-Marques
Journal: Journal of the American College of Cardiology (2012)
BRCA1 Promotes Induction of ssDNA by Ionizing Radiation
Authors: Brian P. Schlegel, Francine M. Jodelka, Rafael Nunez
Journal: Cancer Research (2006)

Abstract The BRCA1 tumor suppressor contributes to the repair of DNA double-strand breaks (DSB) through homologous recombination, but the mechanism is unknown. The rapid accumulation of BRCA1 into nuclear foci in response to induction of DNA breaks suggests that BRCA1 may function in an early step in the repair pathway. We examined the role of BRCA1 in one such early step, the resection of DSBs to generate ssDNA. The appearance of ssDNA in response to ionizing radiation is similar to that of BRCA1 foci formation, suggesting that the two processes are related. Furthermore, BRCA1 colocalizes to ssDNA sites induced by ionizing radiation. Overexpression of BRCA1 causes an increase in cells exhibiting ssDNA induced by ionizing radiation. Mutant BRCA1 that lacks the COOH-terminal BRCT domain also promotes ssDNA but fails to form nuclear foci. Knockdown of BRCA1 expression reduces ssDNA and Rad51 foci formation in response to ionizing radiation. These results indicate that BRCA1 promotes induction of ssDNA in response to ionizing radiation and accumulates at sites of ssDNA. (Cancer Res 2006; 66(10): 5181-9)
The Rachitic Tooth
Authors: Brian L. Foster, Francisco H. Nociti, Martha J. Somerman
Journal: Endocrine Reviews (2014)

Teeth are mineralized organs composed of three unique hard tissues, enamel, dentin, and cementum, and supported by the surrounding alveolar bone. Although odontogenesis differs from osteogenesis in several respects, tooth mineralization is susceptible to similar developmental failures as bone. Here we discuss conditions fitting under the umbrella of rickets, which traditionally referred to skeletal disease associated with vitamin D deficiency but has been more recently expanded to include newly identified factors involved in endocrine regulation of vitamin D, phosphate, and calcium, including phosphate-regulating endopeptidase homolog, X-linked, fibroblast growth factor 23, and dentin matrix protein 1. Systemic mineral metabolism intersects with local regulation of mineralization, and factors including tissue nonspecific alkaline phosphatase are necessary for proper mineralization, where rickets can result from loss of activity of tissue nonspecific alkaline phosphatase. Individuals suffering from rickets often bear the additional burden of a defective dentition, and transgenic mouse models have aided in understanding the nature and mechanisms involved in tooth defects, which may or may not parallel rachitic bone defects. This report reviews dental effects of the range of rachitic disorders, including discussion of etiologies of hereditary forms of rickets, a survey of resulting bone and tooth mineralization disorders, and a discussion of mechanisms, known and hypothesized, involved in the observed dental pathologies. Descriptions of human pathology are augmented by analysis of transgenic mouse models, and new interpretations are brought to bear on questions of how teeth are affected under conditions of rickets. In short, the rachitic tooth will be revealed.
Rapid Estimation of Blood Glucose
Authors: M. MacGregor, R. Robinson
Journal: BMJ (1965)

latrogenic Ulcers of the Small Intestine SIR,--We should like to report another possible case of ileal ulceration and perforation in a patient receiving enteric-coated potassium-chloride tablets but not chlorothiazide.In June, 1964, a woman aged 58 was diagnosed as having pemphigus vulgaris.