Acute Monarticular Arthritis After Vaccination
Authors: HOWARD M. SILBY
Journal: Annals of Internal Medicine (1965)

Case Studies1 February 1965Acute Monarticular Arthritis After VaccinationReport of a Case with Isolation of Vaccinia Virus from Synovial FluidHOWARD M. SILBY, M.D., ROGER FARBER, M.D., CORNELIUS J. O'CONNELL, M.D., JULIAN ASCHER, M.D., EDWARD J. MARINE, M.D.HOWARD M. SILBY, M.D., ROGER FARBER, M.D., CORNELIUS J. O'CONNELL, M.D., JULIAN ASCHER, M.D., EDWARD J. MARINE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-347 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptArthritis has been described as an occasional complication of several viral diseases. However, to the authors' knowledge, the isolation of a specific virus from human synovial fluid in such cases has not been reported previously. The present report documents a case of acute monarticular arthritis after smallpox vaccination in which vaccinia virus was recovered from the synovial fluid.CASE REPORTE. J. (BGH 293446), a 65-year-old Negro female, was admitted to the Buffalo General Hospital on June 25, 1963, because of fever and a painful swelling of the right knee. Twelve days previously, at her request, she had been vaccinated...References1. KEMPE CH: Diagnostic Procedures for Viral and Rickettsial Diseases: Variola and Vaccinia, 2nd ed., American Public Health Association, New York, 1956. Google Scholar2. CUTCHINSWAVENJONES EJWP: The antibody response to smallpox vaccination as measured by a tissue culture plaque method. J. Immun. 85: 275, 1960. MedlineGoogle Scholar3. FAGRAEUSESPMARK A#: Use of a 'mixed haemadsorption' method in virus-infected tissue cultures. Nature (London) 190: 370, 1961. CrossrefMedlineGoogle Scholar4. BARRONMILGROMKARZONWITEBSKY ALEDE: Demonstration of human measles antibody by mixed agglutination. J. Immun. 90: 908, 1963. MedlineGoogle Scholar5. BRINKMAN E: Frühzeitige epiphysenverknöcherung und osteomyelitis variolosa. Z. Orthop. Chir. 57: 208, 1932. Google Scholar6. SOLITO M: Rara lesione ossea di natura probabilmente vaccinica. Quad. Radiol. 3: 73, 1932. Google Scholar7. VALENTI B: Epifisite femorale superiore (malattie di calvèperthes) susseguita alla vaccinazione jenneriana. Pediatria (Naples) 40: 248, 1932. Google Scholar8. DELANOBUTLER PC: Etiology of infantile cortical hyperostosis. Amer. J. Roentgen. 58: 633, 1947. Google Scholar9. SEWALL S: Vaccinia osteomyelitis. Bull. Hosp. Joint Dis. 10: 59, 1949. Google Scholar10. HAARMEINERTZ HO: Akute osteomyelitis nach pochen- und typhusschutzimpfung. München. Med. Wschr. 96: 87, 1954. MedlineGoogle Scholar11. BARBEROGRAYSCOTTMCNAIRKEMPE GATFCH: Vaccinia gangrenosa treated with hyperimmune vaccinial gamma globulin. Pediatrics 16: 609, 1955. MedlineGoogle Scholar12. COCHRANCONNOLLYTHOMPSON WJHID: Bone involvement after vaccination against smallpox. Brit. Med. J. 2: 285, 1963. CrossrefMedlineGoogle Scholar13. KINIKESAVASWAMY MGP: Role of smallpox in production of deformities by causing infection of bones and joints. Antiseptic 38: 169, 1941. Google Scholar14. ELLIOT WD: Vaccinial osteomyelitis. Lancet 2: 1053, 1959. CrossrefMedlineGoogle Scholar15. SIEGERT R: Das verhalten des vakzinevirus im organismus bei zentralnervösen impfschäden. 1. Mitteilung: Virusbefunde an der impfstelle, in den regionären lymphknoten und im blut. Deutsch Med. Wschr. 82: 2021-2024, 2055, 1957. CrossrefMedlineGoogle Scholar16. DOWNIE AW: Smallpox, cowpox, and vaccinia, in Viral and Rickettsial Infections of Man, 3rd ed. Edited by RIVERS, T., HORSFALL, F., J. B. Lippincott Co., Philadelphia, 1959, pp. 690-691. Google Scholar17. O'CONNELLKARZONBARRONPLAUTALI CJDTALMEVM: Progressive vaccinia with normal antibodies. A case possibly due to deficient cellular immunity. Ann. Intern. Med. 60: 282, 1964. LinkGoogle Scholar18. BUDDINGH GJ: A study of generalized vaccinia in the chick embryo. J. Exp. Med. 63: 227, 1936. CrossrefMedlineGoogle Scholar19. LEWIS GW: Polyarthritis in rubella. Rheumatism 10: 66, 1954. MedlineGoogle Scholar20. LEEBARNETTSCHOLERBRYNERCLARK PRAFJFSWH: Rubella arthritis, a study of twenty cases. Calif. Med. 93: 125, 1960. MedlineGoogle Scholar21. CHAMBERSBYWATERS RJEG: Rubella synovitis. Ann. Rheum. Dis. 22: 263, 1963. CrossrefMedlineGoogle Scholar22. CHATTERJEE RN: Incidence of arthritis in smallpox. Indian M. Gaz. 85: 49, 1950. MedlineGoogle Scholar23. COCKSHOTTMACGREGOR PM: Osteomyelitis variolosa. Quart. J. Med. 27: 369, 1958. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Buffalo, New YorkFrom the Department of Medicine and the Department of Bacteriology and Immunology, State University of New York at Buffalo, and the Buffalo General Hospital, Buffalo, N. Y.Requests for reprints should be addressed to Capt. E. J. Marine, USAF(MC), Department of Medicine, Davis-Monthan Air Force Base, Tucson, Ariz. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySmallpox vaccineViral ArthritisVACCINESThe immunobiology of viral arthritidesViral ArthritisSmallpox vaccineEntzündungen bekannter ÄtiologiePoxvirusesIsolation of varicella zoster virus from the synovial fluid of a patient with herpes zoster arthitisThe infectious etiology of chronic rheumatic diseasesVACCINATIONIsolation of echovirus type 11 from synovial fluid in acute monocytic arthritisGelenke, Sehnen und Sehnengleitgewebe, Bursen, FaszienGelenkeEtiology of Mild Acute Infectious MyocarditisGeneral Pathology of the Peripheral JointsAcute monocytic arthritisEchovirus-associated polyarthritis. report of a case with synovial fluid and synovial histologic characterizationRheumatic disorders associated with viral infectionViral Arthritis and the Possible Role of Viruses in Rheumatoid ArthritisViral ArthritisUltrastructural Study of Avian Synovium Infected with an Arthrotropic ReovirusInfectious ArthritisAcute Polyarthritis: Diagnosis and ManagementEpidemic Polyarthritis: A Cytological, Viroiogical and Immunochemical StudyExperimental viral arthritis induced with herpes simplexImmunization and ArthritisViral ArthritisJAMES W. SMITH, M.D., JAY P. SANFORD, M.D., F.A.C.P.Rubella Synovitis in a One-Year-Old PatientCardiac Complications of Progressive Generalized VacciniaBone and joint involvement in virus disease 1 February 1965Volume 62, Issue 2Page: 347-350KeywordsArthritisHospital medicineImmunologyInflammationKneesPathogenesisSmallpoxSynovial fluidViral diseasesViremia Issue Published: 1 February 1965 PDF downloadLoading ...