tbuckley/cabot-search huggingface dataset:
Thymosin Therapy Creates a “Hassall”(?)
Authors: Richard Hong, Sheldon Horowitz
Journal: New England Journal of Medicine (1975)

Complete acceptance of transplanted organs can easily be accomplished without the need for immunosuppression in patients who lack a thymus gland. In these cases, then, the defect allows a simple cure. It was predicted in 1968 that isolated thymic (T-cell) deficiency would easily be cured by thymus transplantations.1 In fact, this prediction was realized shortly thereafter in two patients with the embryonic thymus syndrome of DiGeorge.2,3 Interestingly enough, the establishment of a long-lived dividing population of T cells of donor origin was not shown in either case. This observation, combined with the rapid return to normal of peripheral blood lymphocyte . . .
Specific Value of Drugs in Psychiatric Illness
Authors: Leo E. Hollister, John E. Overall
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Whenever results of an experiment disagree with common cant, one can expect criticism. We do not claim infallibility, but we have devised the best study we know how to do, and accordingly we cannot disavow the results, however surprising. Dr. Ostow makes many specific criticisms of our study, but most bear on the point that controlled drug investigations are less to be trusted than the judgment of any well-intentioned clinician who gives his patients drugs to make them well. This assertion extends far beyond the study under question and deserves answering. The major bogeyman of the controlled trial is alleged to be the removal of the clinician from the patient. Just why this should be so is not made clear, but phrases such as "mechanical scale ratings" and "excessive methodologic refinement" imply this to be a necessary concomitant. Actually, no rating scale is mechanical; all are based
Recognition of Prostate and Melanoma Tumor Cells by Six-Transmembrane Epithelial Antigen of Prostate–Specific Helper T Lymphocytes in a Human Leukocyte Antigen Class II–Restricted Manner
Authors: Hiroya Kobayashi, Toshihiro Nagato, Keisuke Sato, Naoko Aoki, Shoji Kimura, Masamoto Murakami, Hajime Iizuka, Makoto Azumi, Hidehiro Kakizaki, Masatoshi Tateno, Esteban Celis
Journal: Cancer Research (2007)

Abstract The six-transmembrane epithelial antigen of prostate (STEAP) protein is an attractive candidate for T cell–based immunotherapy because it is overexpressed in prostate cancer and various other tumor types. Several peptide epitopes capable of stimulating CTLs that killed STEAP-expressing tumor cells have been described. Our goal was the identification of helper T lymphocyte (HTL) epitopes of STEAP for the optimization of T cell–based immunotherapies against STEAP-expressing malignancies. Candidate HTL epitopes for STEAP were predicted using in silico algorithms for HLA class II–binding peptides and were tested for their ability to elicit HTL responses by in vitro peptide vaccination of CD4 T lymphocytes from healthy individuals and prostate cancer patients. Two peptides (STEAP102–116 and STEAP192–206) were effective in stimulating in vitro antitumor HTL responses in both normal individuals and prostate cancer patients. Notably, both STEAP HTL peptides behaved as promiscuous T-cell epitopes because they stimulated T cells in the context of more than one MHC class II allele. These newly described STEAP HTL epitopes could be of value for the design and optimization of T cell–based immunotherapy against STEAP-expressing tumors. [Cancer Res 2007;67(11):5498–504]
The Hepatitis Carrier and Ethical Issues
Authors: MICHAEL REICHGOTT
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 October 1981The Hepatitis Carrier and Ethical IssuesMICHAEL REICHGOTT, M.D., PH.D, IRWIN SINGER, M.D.MICHAEL REICHGOTT, M.D., PH.DSearch for more papers by this author, IRWIN SINGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-4-513 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their article "Conflicting Duties to Patients: The Case of a Sexually Active Hepatitis B Carrier," Perkins and Jonsen (1) admirably review two difficult questions: namely, the infectivity of chronic hepatitis carriers and the ethical responsibilities created by the physician-patient relationship. But their conclusion that the physician's responsibility is most appropriately focused on the "immediate" patient's trust relationship seems limited.First, the fact of hepatitis B carrier state is not confidential information in the case presented. This knowledge is already held by the employee health officer of the hospital. Therefore, a different ethical question can be raised:...References1. PERKINSJONSEN HA. Conflicting duties to patients: the case of a sexually active hepatitis B carrier. Ann Intern Med. 1981;94(Part 1):523-30. LinkGoogle Scholar2. Ethics in Occupational Medicine. Lancet. 1980;2:134. Book review. MedlineGoogle Scholar1. PERKINSJONSEN HA. Conflicting duties to patients: the case of a sexually active hepatitis B carrier. Ann Intern Med. 1981;94(Part 1):523-30. LinkGoogle Scholar2. KIERNANPOWERS TR. Hepatitis B virus: inappropriate reactions to transmission risks. JAMA. 1979;241:585-7. CrossrefMedlineGoogle Scholar3. KIERNANPOWERS TR. Hepatitis B virus in hemodialysis patients: transmission risks and psychosocial reactions. Arch Intern Med. In press. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1981Volume 95, Issue 4Page: 513-514KeywordsChronic hepatitisHepatitis AHepatitis BPrevention, policy, and public health Issue Published: 1 October 1981 PDF DownloadLoading ...
Regulation of multiple myeloma survival and progression by CD1d
Authors: Emmanouil Spanoudakis, Ming Hu, Kikkeri Naresh, Evangelos Terpos, Valeria Melo, Alistair Reid, Ioannis Kotsianidis, Saad Abdalla, Amin Rahemtulla, Anastasios Karadimitris
Journal: Blood (2008)
Liver failure induced by paracetamol.
Authors: G P Bray
Journal: BMJ (1993)

in 1989, by the end of 1991 half of all senior registrars were accredited, one third of them having been in the grade for over six years.A freeze on recruitment of senior registrars was imposed for at least two years,5 thus ruining the career prospects of dozens of registrars trained in the specialty.6As medical staffing budgets are finite any increase in the number of career registrars and senior registrars uses up money that would otherwise be available for expanding the number of consultants.Also, given a finite pool of doctors, increasing the numbers of consultants requires shorter, better training and reductions in numbers of the juniors.Achieving a Balance has not failed-it has not yet been tried.JPAC may even be worsening the problems of staffing that it was established to solve.What is needed is the urgent introduction of single tier training schemes of shortened duration with wastage rates of around 1 0%.The numbers in these training schemes must be balanced with realistic estimates of the growth in the numbers of consultants, which should be increased and funded centrally by government.The grim alternative is that in a few years many more specialties will be in the position of thoracic medicine and more junior doctors will spend even longer in the training grades.
Regional myocardial blood flow and segmental wall function after oxyfedrine administration in the ischaemic porcine heart
Authors: H. C SCHAMHARDT, P. D VERDOUW, T. M V. D. HOEK, P. R SAXENA
Journal: Cardiovascular Research (1980)

The effects of the cardiostimulant oxyfedrine on segmental myocardial wall function and regional myocardial blood flow were investigated in normally perfused and ischaemic regions in the porcine heart. Myocardial ischaemia was induced by reducing the left anterior descending coronary artery flow to approximately 40% of its baseline value. Six animals served as controls, while oxyfedrine (0.15 mg·kg−1) was administered to 11 animals after 10 min of flow reduction. The induction of ischaemia caused the maximum rate of rise of left ventricular pressure to decrease by 30 %, mean arterial blood pressure and cardiac output to decrease by 10%, while heart rate remained unchanged. Oxyfedrine increased the maximum rate of left ventricular pressure development to 25% above its baseline value, the mean arterial blood pressure to pre-occlusion values, and heart rate by 20%. Flow reduction resulted in a decrease in the flow to the central core of the ischaemic area from 1.27±0.19 to 0.67±0.15 cm3·min−1·g−1 and decreased the endo/epi-ratio from 0.96±0.03 to 0.65± 0.13 (P <0.001). Oxyfedrine increased the flow to the ischaemic area to 1.01 ±0.21 cm3·min−1·g−1 (P <0.05), but did not affect the endo /epi-ratio. The flow to the normally perfused region increased from 1.30±0.16 to 1.41 ±0.13 cm3·min−1·g−1. Without pronounced effects on the end-diastolic myocardial wall thickness (EDT), the mean velocity of systolic wall thickening, which declined to virtually zero during flow reduction, increased to 40% of the baseline value after drug administration. The systolic thickening itself returned to 18 ±5% of EDT; the values at the baseline and during flow reduction being 49 ±5 and 5.2 ±2.3% of EDT, respectively. The combined effect on the end-systolic thickness was a return to 78 % of the baseline value. It is concluded that oxyfedrine increases the blood flow to both the normal and the ischaemic myocardium, the velocity of systolic myocardial wall thickening and improves the ischaemic myocardial performance.
Listening and talking to patients. I: The problem.
Authors: C Fletcher
Journal: BMJ (1980)

and conclusions Aged patients with dementia if not stricken by an acute disease sooner or later approach a terminal phase that is distinguished by a failure of spoon feeding.This con- dition induces great anxiety in the workers who care for these patients.The interaction between patient and care- worker during spoon-feeding failure is described by the psychological model of double-binding.Two serious consequences of double-binding are the distancing of the care-workers from the patient and scapegoating among the care-workers.It is essential that the pressure of double-bindings in the wards should be reduced.
Bile salt toxicity aggravates cold ischemic injury of bile ducts after liver transplantation in Mdr2 +/− mice
Authors: Harm Hoekstra, Robert J. Porte, Yinghua Tian, Wolfram Jochum, Bruno Stieger, Wolfgang Moritz, Maarten J.H. Slooff, Rolf Graf, Pierre A. Clavien
Journal: Hepatology (2006)

Intrahepatic bile duct strictures are a serious complication after orthotopic liver transplantation (OLT). We examined the role of endogenous bile salt toxicity in the pathogenesis of bile duct injury after OLT. Livers from wild-type mice and mice heterozygous for disruption of the multidrug resistance 2 Mdr2 gene (Mdr2+/-) were transplanted into wild-type recipient mice. Mdr2+/- mice secrete only 50% of the normal amount of phospholipids into their bile, leading to an abnormally high bile salt/phospholipid ratio. In contrast to homozygous Mdr2-/- mice, the Mdr2+/- mice have normal liver histology and function under normal conditions. Two weeks after OLT, bile duct injury and cholestasis were assessed by light and electron microscopy, as well as through molecular and biochemical markers. There were no signs of bile duct injury or intrahepatic cholestasis in liver grafts from wild-type donors. Liver grafts from Mdr2+/- donors, however, had enlarged portal tracts with cellular damage, ductular proliferation, biliostasis, and a dense inflammatory infiltrate after OLT. Parallel to this observation, recipients of Mdr2+/- livers had significantly higher serum transaminases, alkaline phosphatase, total bilirubin, and bile salt levels, as compared with recipients of wild-type livers. In addition, hepatic bile transporter expression was compatible with the biochemical and histological cholestatic profile found in Mdr2+/- grafts after OLT. In conclusion, toxic bile composition, due to a high biliary bile salt/phospholipid ratio, acted synergistically with cold ischemia in the pathogenesis of bile duct injury after transplantation.
Archives of Ophthalmology welcomes its seventh editor
Authors: Phil Gunby
Journal: JAMA (1984)

This summer marks the debut of the seventh editor in the 115-year history of the American Medical Association'sArchives of Ophthalmology. He is Morton F. Goldberg, MD, professor and head, Department of Ophthalmology, University of Illinois College of Medicine, Chicago. Joel Sugar, MD, associate professor of ophthalmology, Eye and Ear Infirmary, University of Illinois, Chicago, also joins the monthly specialty journal in the newly created position of associate editor. The new editor succeeds Frederick C. Blodi, MD, who has been professor and chair, Department of Ophthalmology, University of Iowa College of Medicine, Iowa City. Blodi will become director of academic affairs, Institute of Ophthalmology, King Khaled University, Riyadh, Saudi Arabia. Goldberg has served as one of Blodi's editorial board members since 1980 and also has served on the editorial boards of ten other journals. A native of Lawrence, Mass, Goldberg graduated magna cum laude from Harvard College (the undergraduate program
Pregnancy and Coarctation of the Aorta
Authors: JD MORTENSEN
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Dr. Mendelson's monumental monograph on cardiovascular disease and pregnancy became known to me only after our study was reported. His excellent review of the literature and summary tables are valuable additions to the useful information on this subject. We are gratified to note that our study corroborates the conclusions which were made four years earlier by Dr. Mendelson and which were based on collection of cases from the literature.
Correlation of Pretreatment Serum Nonprotein-Bound Cortisol and Total 17-Hydroxycorticosteroid Values with Survival in Patients with Prostatic Cancer
Authors: Clyde E. Blackard, David P. Byar, Ulysses S. Seal, Richard P. Doe
Journal: New England Journal of Medicine (1974)

Abstract Serum nonprotein-bound Cortisol and total 17-hydroxycorticosteroid values determined before and after treatment in a large series of patients with prostatic cancer constituted important variables in predicting survival; 17-hydroxycorticosteroid levels appeared to be a better prognostic indicator of death in the first year than the patient's age, treatment, or stage of disease. In general, the higher the initial value of the serum nonprotein-bound cortisol and 17-hydroxycorticosteroid, the greater the probability of death during the first year of treatment. There was no preponderance of one type of death over another when patients with initial high and low values were compared. (N Engl J Med 291:751–755, 1974)
Recent Advances: Obstetrics
Authors: P. Steer
Journal: BMJ (1995)

Changing Childbirth, the report of the expert com- mittee chaired by Lady Cumberlege,' followed the recommendations of the Winterton committee2 in emphasising choice: freedom for women to choose a home confinement, pool birth, or elective caesarean section.Choice means shifting much decision making from professionals to women, which many find challenging; it also has cost implications.The flexi- bility, skill, and knowledge required to give women choice demands higher standards of professional train- ing, particularly for midwives, whose enhanced role has forced obstetricians and general practitioners to rethink their own.
Automaticity and inhibition in action planning
Authors: Matthew R. Longo, Bennett I. Bertenthal
Journal: Behavioral and Brain Sciences (2004)

We question the generalizability of Glover's model because it fails to distinguish between different forms of planning. The highly controlled experimental situations on which this model is based, do not reflect some important factors that contribute to planning. We discuss several classes of action that seem to imply distinct planning mechanisms, questioning Glover's postulation of a single “planning system.”
Glomerulitis in Typhoid Fever
Authors: JAMES P. LOGERFO
Journal: Annals of Internal Medicine (1974)

Comments and Corrections1 December 1974Glomerulitis in Typhoid FeverJAMES P. LOGERFO, M.D.JAMES P. LOGERFO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-6-861 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: After having read the article by Dr. Sitprija and associates (Ann Intern Med 81:210-213, 1974), I had several questions concerning the statement claiming "informed consent" and your editorial policy concerning articles based on possible breaches of a physician's ethical responsibility of primum non nocere.The article concerns three patients, including a 16-year-old, who had typhoid fever with no clinically significant renal disease and who underwent renal biopsy, presumably for the advancement of scientific knowledge. The biopsy apparently had no bearing in terms of the patient's own diagnosis or prognosis, nor would it significantly alter the care of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES P. LOGERFO, M.D.Affiliations: Department of Health Services, SC-37 School of Public Health and Community Medicine University of Washington Seattle, Washington 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1974Volume 81, Issue 6Page: 861-862KeywordsBiopsyGlomerulonephritisRenal diseasesTyphoid ePublished: 1 December 2008 Issue Published: 1 December 1974 PDF downloadLoading ...
Clinical Trials: Time for Action
Authors: Barrie R. Cassileth
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.12.070 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12610171 Clinical Trials: Time for Action Barrie R. CassilethxBarrie R. CassilethSearch for articles by this author Show More Memorial Sloan-Kettering Cancer Center, New York, NY https://doi.org/10.1200/JCO.2003.12.070 Full Text PDF Figures and Tables "Clinical Trials: Time for Action." Journal of Clinical Oncology, 21(5), pp. 765–766© 2003 by American Society of Clinical Oncology
Why so negative about preventing cognitive decline and dementia? The jury has already come to the verdict for physical activity and smoking cessation
Authors: Leon Flicker, Teresa Liu-Ambrose, Arthur F Kramer
Journal: British Journal of Sports Medicine (2010)

The world is ageing rapidly, and accompanying this demographic transition will be a significant increase in the number of people with dementia, a condition that will affect the developing world more greatly than the developed world, in both absolute numbers and proportional increase.1 The human and financial costs of this condition have, not surprisingly, been of concern to older people, their families and policy makers around the world as they grapple with what will eventually be a major cause of life years lost to disability. The search is on for safe, effective and hopefully, affordable ways to prevent this common and devastating condition of older people.

Against this background, it was timely for the US Department of Health and Human Services National Institutes of Health (NIH) to host a consensus conference on ‘Preventing Alzheimer’s Disease and Cognitive Decline,'2 supported by an Evidence Based Review.3 Many of the other scourges of old age have already demonstrated a reduction in age specific incidence, and thus there is hope that similar outcomes may be achieved for dementia. For example, there has been a 25% reduction in age-adjusted stroke death rates in the USA,4 an observation confirmed in Australia where further data indicate that this is more likely to be due to a decreased incidence of stroke rather than an improvement in survival following a stroke.5 Similarly, after an earlier increase, age-adjusted female hip fracture incidence decreased between 1995 and 2005 by about 25%.6 Therefore, prevention of these common problems of older people may be achievable and a goal for which it is worth striving. The degree of difficulty in ascertaining the population prevalence and incidence of dementia, and also the fact that many of the higher-quality studies were completed over two decades ago, makes it unlikely that …
Sjögren's Syndrome: Association of Anti-Ro(SS-A) Antibodies with Vasculitis, Hematologic Abnormalities, and Serologic Hyperreactivity
Authors: ELAINE L. ALEXANDER
Journal: Annals of Internal Medicine (1983)

The clinical significance of autoantibodies to Ro(SS-A) and La(SS-B) in Sjögren's syndrome was examined in a retrospective evaluation of 75 patients with symptoms of the sicca complex who had either primary Sjögren's syndrome or Sjögren's syndrome associated with another connective tissue disease. The clinical, hematologic, and serologic features associated with autoantibodies to the small molecular weight ribonucleoproteins Ro(SS-A) and La(SS-B) were ascertained. A striking clinical association of anti-Ro(SS-A) antibodies (found in 33 patients) with extraglandular disease (vasculitis, purpura, and lymphadenopathy) was seen. Hematologic abnormalities (anemia, leukopenia, and thrombocytopenia) were also associated with the presence of anti-Ro(SS-A) antibodies. Furthermore, anti-Ro(SS-A) antibody was associated with hyperglobulinemia, increased serologic reactivity in terms of rheumatoid and antinuclear factors, cryoglobulinemia, and hypocomplementemia. The presence of anti-Ro(SS-A) antibodies defines a subset of patients with Sjögren's syndrome who have systemic clinical manifestations including vasculitis, hematologic abnormalities, and serologic hyperreactivity.
Experts Ponder Treating Prehypertension
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response to Letter Regarding Article, "Syncope in High-Risk Cardiomyopathy Patients With Implantable Defibrillators: Frequency, Risk Factors, Mechanisms, and Association With Mortality: Results From the Multicenter Automatic Defibrillator Implantation Trial–Reduce Inappropriate Therapy (MADIT-RIT) Study"
Authors: Martin H. Ruwald, Ken Okumura, Takeshi Kimura, Kazutaka Aonuma, Morio Shoda, Valentina Kutyifa, Anne-Christine Ruwald, Scott McNitt, Wojciech Zareba, Arthur J. Moss
Journal: Circulation (2014)