tbuckley/cabot-search huggingface dataset:
Age-related proliferative activity in dermal melanocytic naevi detected by PCNA/cyclin expression
Authors: P. TU*, S. MIYAUCHI, Y. MIKI
Journal: British Journal of Dermatology (1993)

A monoclonal antibody was used to demonstrate proliferating cell nuclear antigen in routine, formalin‐fixed, paraffin‐embedded tissue sections of dermal melanocytic naevi, including naevus naevocellularis partim lipomatodes, in different age‐groups. The labelling indices of the melanocytic naevus cells were < 1% of those in the overlying epidermal basal cells, and showed a statistically significant decrease with ageing, and also in naevus naevocellularis partim lipomatodes, whereas the indices of the basal cells in the overlying interfollicular epidermis did not show any age‐related changes.
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses
Authors: Tak W Mak, Arda Shahinian, Steve K Yoshinaga, Andrew Wakeham, Louis-Martin Boucher, Melania Pintilie, Gordon Duncan, Beata U Gajewska, Matthew Gronski, Urs Eriksson, Bernhard Odermatt, Alexandra Ho, Denis Bouchard, John S Whorisky, Manel Jordana, Pamela S Ohashi, Tony Pawson, Friedhelm Bladt, Anna Tafuri
Journal: Nature Immunology (2003)
The Effects of Early Corticosteroid Therapy on the Skin Eruption and Pain of Herpes Zoster
Authors: William H. Eaglstein
Journal: JAMA (1970)

Healthy patients with early painful herpes zoster were treated with corticosteroid orally or lactose tablets in a double-blind fashion. The duration of postherpetic neuralgia was shortened by treatment with the corticosteroid. Corticosteroid therapy did not affect pain during the first two weeks or the rate of skin healing. The duration of postherpetic neuralgia could not be predicted by the healing rate of the skin. Control patients less than 60 years old had rapid resolution of their neuralgia while those more than 60 years old had slower resolution of the pain. Corticosteroid therapy did not cause generalization of the eruption.
ADMA, proteinuria, and insulin resistance in non-diabetic stage I chronic kidney disease
Authors: K. Caglar, M.I. Yilmaz, A. Sonmez, E. Cakir, A. Kaya, C. Acikel, T. Eyileten, M. Yenicesu, Y. Oguz, C. Bilgi, C. Oktenli, A. Vural, C. Zoccali
Journal: Kidney International (2006)
PRIMARY TUBERCULOSIS OF THE PERITONEUM, CURED BY CELIOTOMY. FOUR CASES.Read in the Section of Practice of Medicine, at the Forty-fifth Annual Meeting of the American Medical Association held at San Francisco, June 5-8, 1894.
Authors: W. F. McNUTT
Journal: JAMA (1894)

These four cases of primary tubercular peritonitis, are reported on account of the doubt and speculation that still exist as to the etiology of this disease. Most writers maintain that tubercular peritonitis is necessarily secondary. There can scarcely be a question about these cases being primary; the fact that there were no indications of the presence of tuberculosis, or any other disease, together with the fact that the cases all recovered after operation, and show no evidence of disease since, is almost proof positive that in these cases the disease was primary and confined to the peritoneum. The question might arise as to those inflammatory products being the result of Koch's bacilli. In each of these four cases on opening the abdomen, the peritoneum, both visceral and mural layer, was studded with thousands of miliary tubercular bodies, that is shiny, hard little granules on the surface of the membrane. Unfortunately
TIMI Frame Count
Authors: C. Michael Gibson, Christopher P. Cannon, William L. Daley, J. Theodore Dodge, Barbara Alexander, Susan J. Marble, Carolyn H. McCabe, Lori Raymond, Terry Fortin, W. Kenneth Poole, Eugene Braunwald
Journal: Circulation (1996)

Background Although the Thrombolysis in Myocardial Infarction (TIMI) flow grade is a valuable and widely used qualitative measure in angiographic trials, it is limited by its subjective and categorical nature. Methods and Results In normal patients and patients with acute myocardial infarction (MI) (TIMI 4), the number of cineframes needed for dye to reach standardized distal landmarks was counted to objectively assess an index of coronary blood flow as a continuous variable. The TIMI frame-counting method was reproducible (mean absolute difference between two injections, 4.7±3.9 frames, n=85). In 78 consecutive normal arteries, the left anterior descending coronary artery (LAD) TIMI frame count (36.2±2.6 frames) was 1.7 times longer than the mean of the right coronary artery (20.4±3.0) and circumflex counts (22.2±4.1, P &lt;.001 for either versus LAD). Therefore, the longer LAD frame counts were corrected by dividing by 1.7 to derive the corrected TIMI frame count (CTFC). The mean CTFC in culprit arteries 90 minutes after thrombolytic administration followed a continuous unimodal distribution (there were not subpopulations of slow and fast flow) with a mean value of 39.2±20.0 frames, which improved to 31.7±12.9 frames by 18 to 36 hours ( P &lt;.001). No correlation existed between improvements in CTFCs and changes in minimum lumen diameter ( r =−.05, P =.59). The mean 90-minute CTFC among nonculprit arteries (25.5±9.8) was significantly higher (flow was slower) compared with arteries with normal flow in the absence of acute MI (21.0±3.1, P &lt;.001) but improved to that of normal arteries by 1 day after thrombolysis (21.7±7.1, P =NS). Conclusions The CTFC is a simple, reproducible, objective, and quantitative index of coronary flow that allows standardization of TIMI flow grades and facilitates comparisons of angiographic end points between trials. Disordered resistance vessel function may account in part for reductions in flow in the early hours after thrombolysis.
Should health systems agencies be involved in environmental health planning?
Authors: C W Higgins, B U Philips, J G Bruhn, L T Aker
Journal: Environmental Health Perspectives (1980)

Public Law 93-641 provides health systems agencies (HSAs) with a broad planning preview which has enabled a number of agencies to address environmental health issues in their health systems plans. Opponents of HSA involvement in environmental health planning charge that these activities overextend agency resources, duplicate efforts of other government agencies and involve HSAs in "issues of public policy." Closer examination of these charges finds them lacking in validity. The planning activities of health systems agencies are cooperative in nature, drawing upon the planning efforts of other institutions and agencies. It is illogical to exclude environmental concerns from general health planning in light of the impact of the environment upon health. Charges that issues of public policy are inappropriate topics for health planning are seen as attempts to avoid scrutiny of inconsistant legislative policies. Cooperative planning between health systems agencies and environmental health agencies is considered both desirable and essential for the development of effective health planning.
The Basal Ganglia and Their Relation to Disorders of Movements
Authors: H. Richard Tyler
Journal: JAMA (1962)

The second of a series of Oxford Neurological Monographs, this book contains the material presented as the Croonian Lectures in November, 1960, by Professor Denny-Brown. The previous paper on the basal ganglia published in<i>Oxford Medicine</i>in 1945, and as a separate monograph in 1946 has long been a classic in its field. The material presented in this book will become one of the landmarks in the field of neurology and will serve as a taking off point for much work and discussion by others in the future. In this monograph the author presents his concepts of the pertinent clinical anatomy of these nuclei. Of especial interest is his emphasis on the presence of corticostriate fibers which play an important role in the hypothesis he presents and which have not been emphasized before. An interpretative description of pathology in relation to the various "basal ganglia disease" and their syndromes is
The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort
Authors: Greta Pells, George F. Mells, Marco Carbone, Julia L. Newton, Andrew J. Bathgate, Andrew K. Burroughs, Michael A. Heneghan, James M. Neuberger, Darren B. Day, Samantha J. Ducker, Richard N. Sandford, Graeme J. Alexander, David E.J. Jones
Journal: Journal of Hepatology (2013)
Granular cell myoblastoma of the common bile duct treated by biliary drainage and surgery.
Authors: J Dewar, J S Dooley, I Lindsay, P George, S Sherlock
Journal: Gut (1981)

A young Caucasian woman is described in whom obstructive jaundice was caused by a granular cell myoblastoma of the common bile duct. She was treated by percutaneous transhepatic biliary drainage for 10 days, before radical removal. Granular cell myoblastomas are benign lesions of disputed histogenesis, rare among biliary neoplasms, the excision of which is curative.
Changes in Intracardiac Shunt Elicited by Pneumonia
Authors: LUIS J. CACERES, NANDA Y. KHEDKAR, CHARLES J. MARTINEZ, IRA DuBROW, JEFFREY LAKIER
Journal: Clinical Nuclear Medicine (1994)

Radionuclide studies effectively demonstrate changes in cardiopulmonary hemodynamics and have been clinically used to demonstrate intracardiac shunts. The authors present a 6-month-old child with a history of a patent foramen ovale and pulmonary hypertension, presumably due to a left diaphragmatic hernia, who demonstrated accentuated pulmonary hypertension from pneumonia resulting in a right to left shunt. A perfusion scan documented a right-to-left shunt that disappeared on a follow-up lung scan as the patient responded to medical management. In a potential surgery candidate, it is prudent to perform quantitative intracardiac studies after the conditions altering cardiopulmonary hemodynamics are stabilized or treated.
Prognosis and Outcomes of Patients With Community-Acquired Pneumonia
Authors: Michael J. Fine, Melanie A. Smith, Catherine A. Carson, Sunita S. Mutha, Steadman S. Sankey, Lisa A. Weissfeld, Wishwa N. Kapoor
Journal: JAMA (1996)

To systematically review the medical literature on the prognosis and outcomes of patients with community-acquired pneumonia (CAP).A MEDLINE literature search of English-language articles involving human subjects and manual reviews of article bibliographies were used to identify studies of prognosis in CAP.Review of 4573 citations revealed 122 articles (127 unique study cohorts) that reported medical outcomes in adults with CAP.Qualitative assessments of studies' patient populations, designs, and patient outcomes were performed. Summary univariate odds ratios (ORs) and rate differences (RDs) and their associated 95% confidence intervals (CIs) were computed to estimate a summary effect size for the association of prognostic factors and mortality.The overall mortality for the 33,148 patients in all 127 study cohorts was 13.7%, ranging from 5.1% for the 2097 hospitalized and ambulatory patients (in six study cohorts) to 36.5% for the 788 intensive care unit patients (in 13 cohorts). Mortality varied by pneumonia etiology, ranging from less than 2% to greater than 30%. Eleven prognostic factors were significantly associated with mortality using both summary ORs and RDs: male sex (OR = 1.3; 95% CI, 1.2 to 1.4), pleuritic chest pain (OR = 0.5; 95% CI, 0.3 to 0.8), hypothermia (OR = 5.0; 95% CI, 2.4 to 10.4), systolic hypotension (OR = 4.8; 95% CI, 2.8 to 8.3), tachypnea (OR = 2.9; 95% CI, 1.7 to 4.9), diabetes mellitus (OR = 1.3; 95% CI, 1.1 to 1.5), neoplastic disease (OR = 2.8; 95% CI, 2.4 to 3.1), neurologic disease (OR = 4.6; 95% CI, 2.3 to 8.9), bacteremia (OR = 2.8; 95% CI, 2.3 to 3.6), leukopenia (OR = 2.5, 95% CI, 1.6 to 3.7), and multilobar radiographic pulmonary infiltrate (OR = 3.1; 95% CI, 1.9 to 5.1). Assessments of other clinically relevant medical outcomes such as morbid complications (41 cohorts), symptoms resolution (seven cohorts), return to work or usual activities (five cohorts), or functional status (one cohort) were infrequently performed.Mortality for patients hospitalized with CAP was high and was associated with characteristics of the study cohort, pneumonia etiology, and a variety of prognostic factors. Generalization of these findings to all patients with CAP should be made with caution because of insufficient published information on medical outcomes other than mortality in ambulatory patients.
BMA meeting: BMA calls for resignation of English health secretary Andrew Lansley
Authors: H. Jaques
Journal: BMJ (2012)

Doctors at the BMA’s annual representative meeting have narrowly passed a vote of no confidence in secretary of state for health Andrew Lansley and called for his resignation.

Delegates at the conference passed the motion by 158 votes to 124 despite being warned by chairman of council Hamish Meldrum of the negative effect the vote could have on the union’s relationship with …
Diagnostic Criteria in Diabetes
Authors: Samuel Vaisrub
Journal: JAMA (1978)

Reflecting an impaired glucose tolerance, the abnormal glucose tolerance test has for long been considered the criterion for diagnosing diabetes. The test retained this exalted status even when an abnormal glucose tolerance was demonstrated in a variety of other disorders. These were simply dismissed as secondary diabetes. The test remained as the criterion even after familial studies, clinical observations, and plasma-insulin determinations disclosed that it did not differentiate between the juvenile insulin-dependent and the maturity-onset types of diabetes. Elsewhere in this issue (p 833) Turkington and Weinding reject the abnormal glucose-tolerance test as a criterion for diagnosing diabetes. They discredit it primarily because in their series of 334 diabetic patients observed for a period of 18 years, the test failed to predict what is considered to be the hallmark of diabetes, its late complications, particularly diabetic retinopathy, which is specific to diabetes. The only predictor of these complications was insulin
Health care productivity
Authors: Nick Black, John Browne, John Cairns
Journal: BMJ (2006)

Is politically contentious, but can it be measured accurately? 

T he next British general election will probably be fought over the productivity of public services. Opposition parties have already claimed that the unprecedented extra investment in the NHS has been misspent, with medical staff receiving large increases in pay for doing the same, or even less, work. Although an election may be four years away, the government is seeking evidence to show that, contrary to such claims, the extra resources together with organisational reform have increased productivity in the NHS.

This quest is also being driven by an international requirement for governments to measure output from the public sector and by the Department of Health's need to justify its demands to the Treasury for further increases in resources.1 In the political battle that has already started, both government and opposition parties will make claims and counterclaims as to how the productivity of the NHS in the United Kingdom has changed in recent years. So what impact have the extra funds had on productivity?

Until recently, attempts to measure productivity were limited to relating the level of activity in the NHS (such as numbers of consultations and hospital admissions) to the …
Hypertension and Mortality in the Elderly: Further Insights
Authors: Edgar Argulian
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Human autoantibodies against a desmosomal protein complex with a calcium-sensitive epitope are characteristic of pemphigus foliaceus patients.
Authors: R W Eyre, J R Stanley
Journal: The Journal of Experimental Medicine (1987)

Pemphigus foliaceus (PF) patients have antibodies against a tightly, but noncovalently bound complex of polypeptides, which consists of desmoglein I (DGI) and other, possibly desmosomal, proteins. Most PF antibodies bind a calcium-sensitive epitope on this complex and chelation of calcium destroys the reactivity of these sera with the complex, but not the complex itself. The PF sera that do bind the desmosomal complex in the absence of calcium are those sera capable of binding denatured DGI on immunoblotting, and these same sera also immunoprecipitate only DGI when the desmosomal complex is dissociated with SDS. These findings demonstrate that autoantibodies against a complex of desmosome-associated proteins are characteristic of PF and define a calcium-sensitive conformational epitope on this complex.
De Absurdum ad Absurdum!
Authors: Edward Parnall
Journal: JAMA (1974)

To the Editor.—  I refer to Dictionaries and Usage, as contributed by Lester King, MD (226:1564, 1974). He speaks of the palpable  of calling the large mass of the panniculus adiposus a panniculus, when it is bigger than a pannus in a joint. But life is an absurdity after all!  Think of the Italian use of panzone or the Spanish panzon , and then remember that our forefathers saw and named panniculi with a humorous twist, seeing that  apron hanging down to shield the modesty of the obese, long before sober scientists hung a name on what they saw in the dissecting room.  Think of musculus, or musculi, those little mice running around under the skin. And think of those laughing Greek soldiers, when they first saw an elephant and called it a deer (elephas), and saw the hippopotamus and called it a horse of the river.  Thank God
The Prostate Book: Sound Advice on Symptoms and Treatment
Authors: Scott A. Horner
Journal: JAMA (1989)

Despite the prevalence of prostate disease, the public knows little of its symptomatology, natural course, or current therapy. To counter this problem,<i>The Prostate Book</i>is written to inform the educated, inquisitive patient about his malady. In addition to factual details, the author also specifically addresses common patient fears and misconceptions. The description of urology as a science and an art emphasizes the various approaches of urologists to diagnose and treat prostate disease. The anatomy, diagnosis, and surgery of the prostate are discussed in some detail, although the text remains very readable for a college-educated layman. To assist the reader with technical terms, a glossary has been included. The photos and graphics are uncomplicated, pertinent, and clear. Especially well done is the use of the "apple" analogy when describing prostate anatomy and, later, prostate surgery. The occasional use of representative cases enables the patient to relate to the symptoms of
Antiretroviral Therapy for HIV-2 Infected Patients
Authors: N.A. Smith, T. Shaw, N. Berry, C. Vella, L. Okorafor, D. Taylor, J. Ainsworth, A. Choudhury, R.S. Daniels, S. El-Gadi, A. Fakoya, G. Moyle, J. Oxford, R. Tedder, S. O'Shea, A.de Ruiter, J. Breuer
Journal: Journal of Infection (2001)
SPRAYING AND INSUFFLATING THE ACCESSORY NASAL CAVITIES.
Authors: S. S. BISHOP
Journal: JAMA (1901)

In suppuration of the cavities connecting with the nose the question of effectively cleansing and medicating them is a serious one. The ordinary nasal douche and sprays are inefficient. It is necessary that generous quantities of detergent solutions shall not only reach the affected parts, but that they shall flow over them with sufficient force to dislodge and carry away the offensive discharges. The writer has devised a combination of canula and spray tips, shown in the accompanying illustration, which render satisfactory service. They are an adaptation of the Davidson atomizer fitted with spray tips having very large openings, and the outer tip being turned to fit closely into the conical opening of a special canula. The latter is made of silver, and is practically a modification of the Eustachian catheter. Instead of having the beak curved on the arc of a large circle, like that of the catheter, it
Phase II Randomized Trial Comparing Sequential First-Line Everolimus and Second-Line Sunitinib Versus First-Line Sunitinib and Second-Line Everolimus in Patients With Metastatic Renal Cell Carcinoma
Authors: Robert J. Motzer, Carlos H. Barrios, Tae Min Kim, Silvia Falcon, Thomas Cosgriff, W. Graydon Harker, Vichien Srimuninnimit, Ken Pittman, Roberto Sabbatini, Sun Young Rha, Thomas W. Flaig, Ray Page, Sevil Bavbek, J. Thaddeus Beck, Poulam Patel, Foon-yiu Cheung, Sunil Yadav, Edward M. Schiff, Xufang Wang, Julie Niolat, Dalila Sellami, Oezlem Anak, Jennifer J. Knox
Journal: Journal of Clinical Oncology (2014)

Purpose A multicenter, randomized phase II trial, RECORD-3, was conducted to compare first-line everolimus followed by sunitinib at progression with the standard sequence of first-line sunitinib followed by everolimus in patients with metastatic renal cell carcinoma. Patients and Methods RECORD-3 used a crossover treatment design. The primary objective was to assess progression-free survival (PFS) noninferiority of first-line everolimus compared with first-line sunitinib. Secondary end points included combined PFS for each sequence, overall survival (OS), and safety. Results Of 471 enrolled patients, 238 were randomly assigned to first-line everolimus followed by sunitinib, and 233 were randomly assigned to first-line sunitinib followed by everolimus. The primary end point was not met; the median PFS was 7.9 months for first-line everolimus and 10.7 months for first-line sunitinib (hazard ratio [HR], 1.4; 95% CI, 1.2 to 1.8). Among patients who discontinued first-line, 108 (45%) crossed over from everolimus to second-line sunitinib, and 99 (43%) crossed over from sunitinib to second-line everolimus. The median combined PFS was 21.1 months for sequential everolimus then sunitinib and was 25.8 months for sequential sunitinib then everolimus (HR, 1.3; 95% CI, 0.9 to 1.7). The median OS was 22.4 months for sequential everolimus and then sunitinib and 32.0 months for sequential sunitinib and then everolimus (HR, 1.2; 95% CI, 0.9 to 1.6). Common treatment-emergent adverse events during first-line everolimus or sunitinib were stomatitis (53% and 57%, respectively), fatigue (45% and 51%, respectively), and diarrhea (38% and 57%, respectively). Conclusion Everolimus did not demonstrate noninferiority compared with sunitinib as a first-line therapy. The trial results support the standard treatment paradigm of first-line sunitinib followed by everolimus at progression.