Clinical Spectrum of Hemolytic Anemia Associated with Glucose-6-Phosphate Dehydrogenase Deficiency
Authors: EDWARD R. BURKA
Journal: Annals of Internal Medicine (1966)

Article1 April 1966Clinical Spectrum of Hemolytic Anemia Associated with Glucose-6-Phosphate Dehydrogenase DeficiencyEDWARD R. BURKA, M.D., ZEBULON WEAVER III, M.D., PAUL A. MARKS, M.D.EDWARD R. BURKA, M.D., ZEBULON WEAVER III, M.D., PAUL A. MARKS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-4-817 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe susceptibility of certain subjects to primaquine-induced hemolytic anemia was first associated with an intrinsic abnormality of the erythrocytes by Dern and coworkers (1). Subsequent investigations (2-5) demonstrated that the major defect in erythrocytes of these subjects is a deficiency of glucose-6-phosphate dehydrogenase (G-6PD) activity. It is now recognized that hemolytic episodes may occur in affected subjects after exposure to a large number of agents (6-8). Present evidence indicates that G-6PD deficiency is probably one of the most prevalent hereditary enzymatic defects of clinical significance. This report summarizes our clinical experience with anemia associated with G-6PD deficiency over a 6-year...References1. DERNWEINSTEINLEROYTALMADGEALVING RJIMGVDWAS: The hemolytic effect of primaquine. I. The localization of the drug-induced hemolytic defect in primaquine-sensitive individuals. J. Lab. Clin. Med. 43: 303, 1954. MedlineGoogle Scholar2. DERNBEUTLERALVING RJEAS: The hemolytic effect of primaquine. II. The natural course of the hemolytic anemia and the mechanism of its self-limited character. J. Lab. Clin. Med. 44: 171, 1954. MedlineGoogle Scholar3. BEUTLERDERNFLANAGANALVING ERJCLAS: The hemolytic effect of primaquine: VII. Biochemical studies of drug-sensitive erythrocytes. J. Lab. Clin. Med. 45: 286, 1955. MedlineGoogle Scholar4. CARSONFLANAGANICKESALVING PECLCEAS: Enzymatic deficiency in primaquine-sensitive erythrocytes. 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Child. 102: 313, 1961. CrossrefMedlineGoogle Scholar16. ESCOBARHELLERTROBAUGH MAPFE: "Complete" erythrocyte glucose-6-phosphate dehydrogenase deficiency. Arch. Intern. Med. (Chicago) 113: 428, 1964. CrossrefMedlineGoogle Scholar17. GANTWINKS FLGF: Primaquine sensitive hemolytic anemia complicating diabetic acidosis. Clin. Res. 9: 27, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Department of Medicine, Columbia University, College of Physicians and Surgeons, and the Presbyterian Hospital, New York, N. Y.This study was supported in part by grants CA-02332 and GM 07368 from the U. S. Public Health Service, Washington, D. C.Dr. Weaver is a former Trainee in Hematology supported by grant TI-AM-5231 from the Public Health Service, Washington, D. C.Requests for reprints should be addressed to Edward R. Burka, M.D., Jefferson Medical College, 1015 Sansom St., Philadelphia, Pa. 19107. 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PAUL ROBERTSONSplenectomy for hematologic disordersIntroduction to discussion of glucose-6-phosphate dehydrogenase deficiencyErythrocyte glutathione peroxidase deficiencyThe hemolytic process of viral hepatitis inchildren with normal or deficient glucose-6-phosphate dehydrogenase activityRecent Progress in Genetic Hemolytic Disorders: A Practical ApproachPrevalence of Sickle-Cell Trait and Glucose-6-Phosphate Dehydrogenase DeficiencyPrimary Clostridial Pneumonia and EmpyemaEnzyme Multiplicity in the Glycolytic Pathway and the Pentose—Phosphate CycleErthrocyte Glucose-6-Phosphate Dehydrogenase Deficiency a Pharmacogenetic PrototypeGlucose-6-Phosphate Dehydrogenase Deficient Red Cells: Resistance to Infection by Malarial ParasitesInfectious Disease: A Cause of Hemolytic Anemia in Glucose-6 Phosphate Dehydrogenase DeficiencyEDWARD R. BURKA, M.D., F.A.C.P.Glucose-6 Phosphate Dehydrogenase Deficiency, Infectious Hepatitis, Acute Hemolysis, and Renal FailureS. M. PHILLIPS, M.D., N. P. SILVERS, M.D.Recent advances in malariologyGenetically Determined Polymorphisms of Erythrocyte Enzymes in ManAcute Renal Failure Complicating Rickettsial Infections in Glucose-6-Phosphate Dehydrogenase-Deficient IndividualsANDREW WHELTON, JAMES V. DONADIO JR., BENNETT L. ELISBERG, M.D.Virus-Induced Hemolysis in Erythrocytes Deficient in Glucose-6-phosphate DehydrogenaseÜber zwei neue Fälle von hereditärer nichtsphärocytärer hämolytischer Anämie bei Glucose-6-Phosphat-Dehydrogenase-Defekt in einer norddeutschen FamilieNature of Hemolytic Crises and the Fate of G6PD Deficient, Drug-Damaged Erythrocytes in SardiniansAcute Hemolytic Anemia Complicating Viral Hepatitis in Patients with Glucose-6-Phosphate Dehydrogenase DeficiencyGERALD SALEN, M.D., FRANZ GOLDSTEIN, M.D., F.A.C.P., FARID HAURANI, M.D., F.A.C.P., C. WILMER WIRTS, M.D., F.A.C.P.Clinical Implications of Glucose-6-Phosphate Dehydrogenase DeficiencyARNO G. MOTULSKY, M.D., GEORGE STAMATOYANNOPOULOS, M.D. 1 April 1966Volume 64, Issue 4Page: 817-825KeywordsDehydrogenasesGlucose-6-phosphate dehydrogenase deficiencyHematology and oncologyHemolytic anemiaHospital medicineMedical servicesSurgeons Issue Published: 1 April 1966 PDF DownloadLoading ...