Trimethoprim-Sulfamethoxazole and Hyponatremia
Authors: YOU-HERN AHN
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 July 1985Trimethoprim-Sulfamethoxazole and HyponatremiaYOU-HERN AHN, M.D., JOEL M. GOLDMAN, M.D.YOU-HERN AHN, M.D.Search for more papers by this author, JOEL M. GOLDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-1-161_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently, several studies have found a high incidence of adverse reactions to treatment with high-dose intravenous trimethoprim-sulfamethoxazole in patients with pneumocystis pneumonia associated with the acquired immunodeficiency syndrome (1-3). However, it is not generally appreciated that hyponatremia can be associated with the large volumes of fluid required with trimethoprim-sulfamethoxazole treatment. We recently saw such a case and suggest caution in the use of intravenous, high-dose treatment with this combination.A 42-year-old homosexual man with the acquired immunodeficiency syndrome was hospitalized with bilateralPneumocystis cariniipneumonia and oral candidiasis. High-dose trimethoprim-sulfamethoxazole treatment, 20 mg/kg/ body weight · d,...References1. JAFFEABRAMSAMMANN HDA. Complications of co-trimoxazole in treatment of AIDS—associated Pneumocystis carinii pneumonia in homosexual men. Lancet. 1983;2:1109-11. CrossrefMedlineGoogle Scholar2. GORDINSIMONWOFSYMILLS FGCJ. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1984;100:495-9. LinkGoogle Scholar3. KOVACSHIEMENZMACHER JJA. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med. 1984;100:663-71. LinkGoogle Scholar4. DEANSLANGSMITH KJD. Stability of trimethoprim-sulfamethoxazole injection in five infusion fluids. Am J Hosp Pharm. 1982;39:1681-4. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: YOU-HERN AHN, M.D.; JOEL M. GOLDMAN, M.D.Affiliations: Coney Island Hospital Brooklyn, N.Y. 11235 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnalysis of the Clinical Characteristics of Hyponatremia Induced by Trimethoprim/SulfamethoxazoleTrimethoprim-associated electrolyte and acid-base abnormalitiesHyponatremia With Intravenous Sulfamethoxazole/Trimethoprim in ChildrenTrimethoprim-sulfamethoxazole-induced hyponatremia in an elderly lady with Achromobacter xylosoxidans pneumoniaTreatment of Pneumocystis jirovecii pneumonia in HIV-infected patients: a reviewTrimethoprim-Sulfamethoxazole-Induced HyponatremiaFluid, electrolyte and acid–base disorders associated with antibiotic therapySulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolonesSulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolonesMiscellaneous drugs with nephrotoxic potential (Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones)2 Hypothalamic and pituitary function in AIDSAdrenal Insufficiency in the Intensive Care Setting 1 July 1985Volume 103, Issue 1Page: 161-162KeywordsAIDSAdverse reactionsBody weightCandidiasisHomosexualsHyponatremiaPneumocystisPneumocystis carinii pneumoniaPneumonia ePublished: 1 December 2008 Issue Published: 1 July 1985 PDF downloadLoading ...