tbuckley/cabot-search huggingface dataset:
Long-term preservation of ischemic myocardium in the dog by hyaluronidase.
Authors: R A Kloner, E Braunwald, P R Maroko
Journal: Circulation (1978)

The administration of hyaluronidase is a promising intervention to protect the ischemic myocardium in man, but evidence of the extent to which it may reduce the ultimate size of an infarct is not well-defined. Hence, open chest, anesthetized dogs were randomized into 10 control dogs which received saline and eight treated dogs which received three doses of hyaluronidase (500 NF units/kg I.V.) at 15 minutes, 2 hours and 24 hours after occlusion of the left anterior descending coronary artery (CAO). Regional myocardial blood flow (RMBF) assessed by the microsphere technique was measured 12 minutes after CAO. The chest was then closed and the dogs were allowed to recover. Twenty-one days after CAO, the hearts were excised, divided into 1 cm thick slices and incubated in triphenyl tetrazolium chloride. Infarct size was then determined by planimetry. The left ventricular myocardium was divided into multiple samples for RMBF analysis. In control dogs 23.2 +/- 2% of the left ventricle was infarcted, compared to only 9 +/- 2.8% (P less than 0.001) in hyaluronidase-treated dogs. RMBF in noninfarcted myocardium directly adjacent to the infarct was similar to that in the normal zone remote from the infarct in the control dogs; however, in the hyaluronidase-treated dogs, blood flow in the myocardium adjacent to the infarct was significantly reduced to 68% of normal (P less than 0.01) in the outer myocardial wall and to 86% of normal (P less than 0.02) in the inner myocardial wall, which indicates that this tissue, at least in some part, was in jeopardy, but was salvaged by hyaluronidase. Epicardial electrocardiographic data showed that three weeks after CAO, Q waves were less frequent and smaller in hyaluronidase compared to untreated dogs. Preservation of the frequency and magnitude of R waves was greater in the hyaluronidase-treated group at three weeks. We conclude that hyaluronidase resulted in long-term preservation of the ischemic myocardium.
Pulmonary capillary leak syndrome complicating generalized pustular psoriasis: possible role of cytokines
Authors: J.M. MCGREGOR, J.N.W.N. BARKER, D.M. MACDONALD
Journal: British Journal of Dermatology (1991)

Journal Article Pulmonary capillary leak syndrome complicating generalized pustular psoriasis: possible role of cytokines Get access J.M. MCGREGOR, J.M. MCGREGOR Department of Dermatology, Guy's Hospital. London. U.K. Search for other works by this author on: Oxford Academic Google Scholar J.N.W.N. BARKER, J.N.W.N. BARKER Department of Dermatology, Guy's Hospital. London. U.K. Search for other works by this author on: Oxford Academic Google Scholar D.M. MACDONALD D.M. MACDONALD Department of Dermatology, Guy's Hospital. London. U.K. Dr D.M. MacDonald, Department of Dermatology. Guy's Hospital. St Thomas Street, London SEI 9RT. U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 125, Issue 5, 1 November 1991, Pages 472–474, https://doi.org/10.1111/j.1365-2133.1991.tb14777.x Published: 01 November 1991
A Seronegative Arthropathy and Escherichia coli Diarrhea
Authors: DONALD J. KENNEDY
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984A Seronegative Arthropathy and Escherichia coli DiarrheaDONALD J. KENNEDY, M.D., JOHN A. DUNN, RICHARD N. GREENBERG, M.D.DONALD J. KENNEDY, M.D.Search for more papers by this author, JOHN A. DUNNSearch for more papers by this author, RICHARD N. GREENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-147_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The association of seronegative arthropathies with inflammatory bowel disease, intestinal bypass surgery, or gram-negative infectious diarrhea is well established. The most commonly isolated bacteria responsible for the diarrhea before the onset of arthritis have been invasive organisms of the Enterobacteriaceae family (Salmonella, Shigella, andYersiniaspecies) as well asBrucellaandCampylobacterspecies (1, 2). EnterotoxigenicEscherichia coliis a common cause of acute, self-limited diarrhea, but it is not routinely identified in the clinical laboratory or reported to be associated with seronegative arthropathy (3, 4). We report what we believe is the first case of a...References1. GILLILAND B and ANNIK M. Reiter's syndrome, psoriatic arthritis, arthritis associated with gastrointestinal diseases, and Behcet's syndrome. In: PERTERSDORF RG, ADAMS RD, BRAUNWALD E, ISSELBACHER KJ, MARTIN JB, WILSON JD, eds. Harrison's Principles of Internal Medicine. 10th ed. New York: McGraw-Hill Book Company; 1983: 1989-94. Google Scholar2. KEAT A. Reiter's syndrome and reactive arthritis in perspective. N Engl J Med. 1983;309:1606-15. CrossrefMedlineGoogle Scholar3. GREENBERG R and GUERRANT R. E. coli heat-stable enterotoxin. Pharmacol Ther. 1981;13:507-31. CrossrefMedlineGoogle Scholar4. GUERRANT R. Gastrointestinal infections and food poisoning. In MANDELL GL, DOUGLAS RG JR., BENNETT JE, eds. Principles and Practice of Infectious Diseases. Vol. 1. New York: John Wiley & Sons; 1979:847-62. Google Scholar5. LEINO R, VUENTO R, KOSKIMIES S, VIANDER M, and TOIVANEN A. Depressed lymphocyte transformation by yersinia and Escherichia coli in yersinia arthritis. Ann Rheum Dis. 1983;42:176-81. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONALD J. KENNEDY, M.D.; JOHN A. DUNN; RICHARD N. GREENBERG, M.D.Affiliations: St. Louis City Hospital St. Louis, MO 63104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIncreased translocation of Escherichia coli and development of arthritis in vitamin A-deficient ratsReiter's syndrome and reactive arthritis: A current view 1 July 1984Volume 101, Issue 1Page: 147-148KeywordsClinical laboratoriesDiarrheaDysenteryEnterobacteriaceaeEscherichia coliEscherichia coli infectionsInflammatory bowel diseaseSalmonellaShigellaSurgery ePublished: 1 December 2008 Issue Published: 1 July 1984 PDF downloadLoading ...
An Estimable Legacy
Authors: Carlos J. M. Martini
Journal: JAMA (1990)

The MEDICAL EDUCATION ISSUE of<i>JAMA</i>was initially published 89 years ago, on September 21, 1901. It was also the first time thatThe Journalreported medical education statistical data, with information from 154 medical schools, 26 417 medical students, and 5958 medical school teachers. The editorial in that 1901 issue might well have been written today. The progress of medical education in the United States is one of the most remarkable phases of modern culture that has been observed during the past 15 years. For the motives of this progress we are obliged to look in various directions: to the enormous increase in wealth that has marked our mastery over the physical resources of the earth through modern machinery, to the equally unexpected increase in our knowledge of diseases through the general scientific advancement, and, lastly, to the coincident revival of a science and art of pedagogy. These general
EXPECTANT TREATMENT IN SOME CASES OF ABORTION.
Authors: ADDISON H. FOSTER
Journal: JAMA (1884)

Mrs. A., American, aged 30, multipara, was taken, Christmas day, 1877, with severe labor pains, and expelled a four months' fœtus with very little hæmorrhage. She being very fleshy, the firmly contracted os could barely be reached, and no active interference for the delivery of the placenta was advised. After a rest in bed for a week the patient was allowed to resume her usual household duties. Every few days a little hæmorrhage occurred, with some pain, and about once a month a portion of the placenta was expelled, until the 30th of April, or after four months, the last piece, the size of the thumb, came away as fresh and healthy as any before it. There never occurred any serious hæmorrhage or severe pains during the four months, and very little medicine was taken. The patient often went to town on the street-cars, a ride of over two and
Evaluation of tetrafunctional block copolymers as synthetic vectors for lung gene transfer
Authors: Peggy Richard-Fiardo, Catherine Hervouet, Robert Marsault, Philippe R. Franken, Béatrice Cambien, Julien Guglielmi, Julie Warnez-Soulie, Jacques Darcourt, Thierry Pourcher, Thibault Colombani, Thomas Haudebourg, Pauline Peuziat, Bruno Pitard, Georges Vassaux
Journal: Biomaterials (2015)
Adenoviral Gene Vector Tethering to Nanoparticle Surfaces Results in Receptor-Independent Cell Entry and Increased Transgene Expression
Authors: Michael Chorny, Ilia Fishbein, Ivan S. Alferiev, Origene Nyanguile, Richard Gaster, Robert J. Levy
Journal: Molecular Therapy (2006)

The present studies investigated the hypothesis that affinity immobilization of replication-defective adenoviruses (Ad) on the surfaces of biodegradable nanoparticles (NP) can improve transduction through uncoupling cellular uptake from the coxsackie-adenovirus receptor (CAR). Ad was tethered to the surfaces of polylactide-based NP that were surface-activated using a photoreactive polyallylamine-benzophenone-pyridyldithiocarboxylate polymer, which enabled (via thiol chemistry) the covalent attachment of Ad-binding proteins, either the recombinant D1 domain of CAR or an adenoviral knob-specific monoclonal antibody. Gene transfer by NP-Ad complexes was studied in relation to cellular uptake as a function of cell type and the character of NP-Ad binding. NP-Ad complexes, but not Ad applied with or without control nonimmune IgG-modified NP, significantly increased green fluorescent protein reporter expression in endothelioma and endothelial and arterial smooth muscle cells (SMC) in direct correlation to the extent of NP-Ad internalization. CAR-independent uptake of NP-Ad was confirmed by demonstrating inhibition of free Ad- but not NP-Ad complex-mediated transduction by knob protein. Complexes formulated with an Ad encoding inducible nitric oxide synthase inhibited growth of cultured SMC to a significantly greater extent than those with (GFP)Ad or (NULL)Ad or free vector. It is concluded that Ad-specific affinity tethering to biodegradable NP can significantly increase the level of gene expression via a CAR-independent uptake mechanism.
Kenneth Arthur Newton
Authors: R. H. Phillips, B. Phillips, C. Westbury
Journal: BMJ (2011)

Kenneth Arthur (“Ken”) Newton was an extraordinarily gifted cancer specialist at Westminster Hospital, London, during the second half of the 20th century. His approach to the management of cancer was strongly influenced by an eminent Westminster Hospital surgeon, Sir Stanford Cade, a pioneer in the multidisciplinary management of malignant disease. Sir Stanford sent Ken, at that time a senior registrar, to the United States in 1955 for three months, where, in addition to radiotherapy, he studied the new discipline of cancer chemotherapy. On his return he was well equipped to treat …
BERIBERI FOLLOWING DRASTIC VOLUNTARY DIETARY RESTRICTION
Authors: DAVID RIESMAN
Journal: JAMA (1934)

Beriberi is looked on as a tropical or exotic disease. but the conditions that are alleged to give rise to it may conceivably occur elsewhere. A few instances have been encountered in badly run prisons and insane asylums, but sporadic cases are on the whole sufficiently rare, in this locality at least, to justify us in placing two on record. Beriberi is a vitamin B deficiency disease characterized by cardiovascular changes, edema and polyneuritis. Historically it is a very ancient malady. It appears in Chinese writings of the Sui and Tang dynasties at the beginning of the seventh century. A description dating back to 610 A. D. is clear enought to indicate that a moist and a dry form of the disease were then recognized just as is the case today. Under the name of kakke the malady makes its appearance in Japanese 1iterature in the ninth century. The first
Regenerative potentials of platelet-rich plasma enhanced by collagen in retrieving pro-inflammatory cytokine-inhibited chondrogenesis
Authors: Chia-Che Wu, Wei-Hong Chen, Bin Zao, Pei-Lun Lai, Tzu-Chieh Lin, Hung-Yao Lo, Ying-Hua Shieh, Chih-Hsiung Wu, Win-Ping Deng
Journal: Biomaterials (2011)
INCREASED BASELINE RHO KINASE (ROCK) ACTIVITY IS AN INDEPENDENT PREDICTOR OF 6 MONTH CARDIOVASCULAR OUTCOMES AFTER ACUTE CORONARY SYNDROME (ACS)
Authors: Ming Dong, Mang Zhang, Rui-Jie Li, Qian-Huan Zhang, James K. Liao, Cheuk-Man Yu
Journal: Journal of the American College of Cardiology (2010)
How to reconsider the base rate fallacy without forgetting the concept of systematic processing
Authors: Pablo Fernandez-Berrocal, Julian Almaraz, Susana Segura
Journal: Behavioral and Brain Sciences (1996)

Abstract (1) There is enough contradictory evidence regarding the role of base rates in category learning to confirm the nonexistence of biases in such learning. (2) It is not always possible to activate statistical reasoning through frequentist representation. (3) It is necessary to use the concept of systematic processing in reconsidering the published work on biases.
Immunisation of adults against diphtheria.
Authors: F W Sheffield, A G Ironside, J D Abbott
Journal: BMJ (1978)

She was treated with Triplopen (benethamine and procaine penicillin with benzyl penicillin sodium) 1-2 megaunits intramuscularly daily for ten days.Two weeks after treatment she could drink alcohol without adverse effect.The lymphadenopathy resolved within three weeks.At six months her Wassermann test result was negative and she had had no recurrence of the pain with alcohol.Her regular consort was treated for early latent syphilis but had no history of alcohol-induced pain.
Doppler studies in the growth retarded fetus and prediction of neonatal necrotising enterocolitis, haemorrhage, and neonatal morbidity.
Authors: G A Hackett, S Campbell, H Gamsu, T Cohen-Overbeek, J M Pearce
Journal: BMJ (1987)

In 82 consecutive cases of intrauterine growth retardation managed by established criteria fetal Doppler studies identified 29 fetuses with absence of end diastolic frequencies in the fetal aorta. These same fetuses were significantly more growth retarded (p less than 0.001) and had an earlier gestational age at delivery (p less than 0.001) than those with end diastolic frequencies present. A subgroup of these cases was analysed in more detail to examine the prognostic value of this phenomenon for the neonate. Two groups of neonates of equivalent gestational age and with a birth weight below 2000 g were compared. There were 26 neonates with absent end diastolic frequencies (group 1) and 20 with end diastolic frequencies (group 2) in the fetal aorta. Those in group 1 were more likely to suffer perinatal death (p less than 0.05), necrotising enterocolitis (p less than 0.01), and haemorrhage (p less than 0.05). Only 4 (15%) of the babies in group 1 had an uncomplicated neonatal period compared with 15 (75%) in group 2 (p less than 0.001). The circulatory changes identified in these cases may provide a more sensitive measure of critical fetal compromise than current techniques and thus allow the clinician to deliver the fetus before irreversible tissue damage has occurred.
Declan John O'Brien
Authors: P. Downey
Journal: BMJ (2003)

General practitioner Hereford (b 1954; q Liverpool 1977; MRCGP), died from cancer of the rectum on 26 August 2003.​2003.




Figure 1




Dec worked in Ormskirk for one year before moving to Hereford and joining the vocational training scheme. He became a partner, a trainer, and then course organiser for 10 years. He pioneered the use of problem based learning in vocational training, cowriting three workbooks. Dec was a keen football fan and medical officer to Hereford United. He leaves a wife, Jude, and three children.
Plunged in at the deep end
Authors: K. Molloy
Journal: BMJ (1998)

Editorial by Bantvala and Doyal

On the first morning of my elective, I turned up at the outpatient clinic expecting an introduction on how the hospital was run and what would be expected of me. Instead, I was simply told to “see patients.” I was at the Lady Willingdon hospital, a Christian charitable institution serving the people of Manali, a small town at the base of the Himalayas, and surrounding regions in northern India. It is run by a married couple, Laji and Sheila Varghese, who first came to the mission in 1979.

The workload is huge. Although it is a 35 bed hospital, extra space is often made for another 10 patients. About 150 patients are seen in outpatient clinics every day. The medical staff consists of three doctors, nine nurses (only one with official nursing qualifications), and 10 assistant nurses.

For the outpatient clinic I shared a small room with another doctor. The patients would have one or two relatives accompanying them. All but the most private examinations were carried out on a couch in the corner of the room. Rectal and vaginal examinations were performed behind a flimsy curtain.

One day each week was put aside for elective surgery. Emergency operations were carried out whenever necessary. Almost all the surgery I saw performed was under spinal anaesthesia. Without hi tech monitoring …
Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis
Authors: Kwan Leung Chan, Koon Teo, Jean G. Dumesnil, Andy Ni, James Tam
Journal: Circulation (2010)

Aortic stenosis (AS) is an active process with similarities to atherosclerosis. The objective of this study was to assess the effect of cholesterol lowering with rosuvastatin on the progression of AS.This was a randomized, double-blind, placebo-controlled trial in asymptomatic patients with mild to moderate AS and no clinical indications for cholesterol lowering. The patients were randomized to receive either placebo or rosuvastatin 40 mg daily. A total of 269 patients were randomized: 134 patients to rosuvastatin 40 mg daily and 135 patients to placebo. Annual echocardiograms were performed to assess AS progression, which was the primary outcome; the median follow-up was 3.5 years. The peak AS gradient increased in patients receiving rosuvastatin from a baseline of 40.8+/-11.1 to 57.8+/-22.7 mm Hg at the end of follow-up and in patients with placebo from 41.6+/-10.9 mm Hg at baseline to 54.8+/-19.8 mm Hg at the end of follow-up. The annualized increase in the peak AS gradient was 6.3+/-6.9 mm Hg in the rosuvastatin group and 6.1+/-8.2 mm Hg in the placebo group (P=0.83). Treatment with rosuvastatin was not associated with a reduction in AS progression in any of the predefined subgroups.Cholesterol lowering with rosuvastatin 40 mg did not reduce the progression of AS in patients with mild to moderate AS; thus, statins should not be used for the sole purpose of reducing the progression of AS. Clinical Trial Registration Information- URL: http://www.controlled-trials.com/.ISRCTN 32424163.
Growth factors and angiogenesis
Authors: R. J Schott, L. A Morrow
Journal: Cardiovascular Research (1993)

Journal Article Growth factors and angiogenesis Get access Robert J Schott, Robert J Schott Cardiac Unit, Massachusetts General Hospital, Boston, MA 02114, USA: R J Schott; Geriatric Research, Education and Clinical Center, Brockton/West Roxbury VA Hospital, MA, USA: L A Morrow. Correspondence to Dr Schott. Search for other works by this author on: Oxford Academic PubMed Google Scholar Linda A Morrow Linda A Morrow Cardiac Unit, Massachusetts General Hospital, Boston, MA 02114, USA: R J Schott; Geriatric Research, Education and Clinical Center, Brockton/West Roxbury VA Hospital, MA, USA: L A Morrow. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 7, July 1993, Pages 1155–1161, https://doi.org/10.1093/cvr/27.7.1155 Published: 01 July 1993 Article history Received: 26 February 1992 Accepted: 22 June 1992 Published: 01 July 1993
Nuclear Repositioning Precedes Promoter Accessibility and Is Linked to the Switching Frequency of a Plasmodium falciparum Invasion Gene
Authors: Bradley I. Coleman, Ulf Ribacke, Micah Manary, Amy K. Bei, Elizabeth A. Winzeler, Dyann F. Wirth, Manoj T. Duraisingh
Journal: Cell Host & Microbe (2012)
Palmitate uptake by hepatocyte monolayers. Effect of albumin binding.
Authors: A B Fleischer, W O Shurmantine, B A Luxon, E L Forker
Journal: Journal of Clinical Investigation (1986)

The uptake of 14C-palmitate by rat liver cell monolayers is depressed by binding of the fatty acid to albumin. When the uptake flux is divided by the concentration of free palmitate in the bathing medium, however, the resulting clearance is approximately 14 times greater in the presence of albumin than in its absence. These findings are not accounted for by the different diffusion rates of free and bound palmitate across an unstirred fluid layer, nor attributable to nonequilibrium binding. Instead we argue that the most plausible explanation is accelerated dissociation of albumin-palmitate complexes mediated by the cell surface--an interpretation that also explains the uptake kinetics of other albumin-bound organic anions by perfused rat liver.
644 GENOME-WIDE ASSOCIATION AND HIGH THROUGHPUT GENOTYPE IMPUTATION STUDIES CONFIRM A SUSCEPTIBILITY LOCUS TO HCV INFECTION ON 6P22.1–P21.31
Authors: J.A. Del Campo, M. Maraver, B. Pardo, L. Grande, M. Diago, I. Carmona, R. Andrade, M.C. Rivero, J. Velasco, M.E. Saez, J.J. Galán, R. Ramírez-Lorca, F.J. Morón, J.M. Carrasco, A. Salinas, E. Molero, J.L. Royo, C. Moreno, A. González Pérez, J. Gayan, L.M. Real, A. Ruiz, M. Romero-Gómez
Journal: Journal of Hepatology (2010)
Clinical Trial Registration
Authors: Catherine D. DeAngelis, Jeffrey M. Drazen, Frank A. Frizelle, Charlotte Haug, John Hoey, Richard Horton, Sheldon Kotzin, Christine Laine, Ana Marusic, A. John P. M. Overbeke, Torben V. Schroeder, Hal C. Sox, Martin B. Van Der Weyden
Journal: JAMA (2004)

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