tbuckley/cabot-search huggingface dataset:
Future Bright for Light as Dermatologic Tool
Authors: L. Lamberg
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemodynamics of Complete Transposition of the Great Vessels Before and After the Creation of an Atrial Septal Defect
Authors: REDA M. SHAHER, LANGFORD KIDD
Journal: Circulation (1966)

Pressures, hemoglobin, and oxygen saturations were measured and shunts and flows calculated before and after the surgical creation of an atrial septal defect in 20 patients with complete transposition of the great vessels. Eleven patients had intact ventricular septa and nine had ventricular septal defects. Of the group with intact septa, the shunt increased in nine and diminished in one; arterial oxygen saturation increased in nine and diminished in one; hemoglobin content decreased in eight and increased in two; systemic blood flow increased in six, diminished in two, and was unchanged in one; and pulmonary blood flow diminished in two. Of those with a ventricular septal defect, the shunt increased in all but one; arterial oxygen saturation increased in four, remained the same in two, and diminished in three; hemoglobin content increased in five and diminished in four; systemic blood flows increased in five and diminished in three; and pulmonary blood flows diminished in four. It was concluded that the procedure does not improve arterial oxygen saturation in any patient in whom the arterial oxygen saturation is 65% or more initially, and that this operation is primarily of benefit when there is an intact ventricular septum.
HYSTERICAL VOMITING, RESULTING IN DEATH.Read in Section on Practice of Medicine at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, Cal., June 5-8, 1894.
Authors: H. N. RUCKER
Journal: JAMA (1894)

During the latter part of February, 1893, I was invited by my friend, Dr. J. H. Todd, of Oakland, to see a single lady, aged 21 years, who was suffering from severe vomiting, which had continued for several days without abatement. The Doctor had patiently tried almost every remedy recommended for such conditions, without benefit. The patient could receive no food except by enema; the vomiting was so frequent that but little sleep was obtained, and she was fast becoming exhausted. After a careful examination, I was ready to agree with his diagnosis—hysterical vomiting. Nothing short of large doses of morphin, a half grain hypodermically, gave any rest, and this afforded but a short respite from the vomiting. Thus the case went on till death took place; the vomiting continuing in the very last throes of dissolution. A careful examination of the abdominal viscera revealed nothing to account for the
In-flight Emergencies: Doc Riders in the Sky-Reply
Authors: Bruce B. Dan
Journal: JAMA (1990)

<h3>In Reply.—</h3> In response to Dr Glass, my editorial suggested that flight attendants (and consequently passengers) might benefit from receiving basic life support training, eg, learning to clear a foreign object from the throat, stop an acute hemorrhage, or perform cardiopulmonary resuscitation. The fact that flight attendants might be trained as emergency medical technicians was meant to be tongue-in-cheek. Dr Glass' proposal to have at least one on-board flight attendant trained as an emergency medical technician might one day prove to be useful, but from the airlines' point of view is currently impractical. Crew schedules being what they are (attendants bid for flights on a month-to-month basis), trying to ensure one emergency medical technician on each flight would prove to be a logistic nightmare (not even considering the havoc created in crew schedules by canceled flights, weather delays, and crew illnesses). Dr Glass has accurately characterized what is probably the
The value of home-based collection of biospecimens in reproductive epidemiology.
Authors: John C Rockett, Germaine M Buck, Courtney D Lynch, Sally D Perreault
Journal: Environmental Health Perspectives (2003)

Detection, quantification, and prognosis of environmental exposures in humans has been vastly enhanced by the ability of epidemiologists to collect biospecimens for toxicologic or other laboratory evaluation. Ease of collection and level of invasiveness are commonly cited reasons why study participants fail to provide biospecimens for research purposes. The use of methodologies for the collection of biospecimens in the home offers promise for improving the validity of health effects linked to environmental exposures while maximizing the number and type of specimens capable of being collected in a timely and cost-effective manner. In this review we examine biospecimens (urine and blood) that have been successfully collected from the home environment. Related issues such as storage and transportation will also be examined as well as promising new approaches for collecting less frequently studied biospecimens (including hair follicles, breast milk, semen, and others). Such biospecimens are useful in the monitoring of reproductive development and function.
Endoscopic closure of the NOTES access site to the peritoneal cavity by means of transmural resorbable sutures: an animal survival study
Authors: D von Renteln, A Eickhoff, G Kaehler, K Caca
Journal: Endoscopy (2008)

Corresponding author: Daniel von Renteln MD. Medizinische Klinik I, Klinikum Ludwigsburg, Posilipostr. 4, 71640 Ludwigsburg, Germany. Email: renteln@gmx.net
Hay-Fever Treatment by Dunbar's Remedies (Pollantin).
Authors: Robert Levy
Journal: JAMA (1906)

Denver, Aug. 8, 1906. <h3>To the Editor:</h3> —Dr. Ingals' communication inThe Journal, August 4, is very timely, and it is refreshing to read an apparently honest report, even though relating unsuccessful results. Being a hay-fever subject myself, I hailed with delight Professor Dunbar's remedy, especially after it was endorsed by several of our leading American rhinologists. My first experience, about two years ago, was a dismal failure, and, although I persisted in its use, both for myself and for my patients, I was finally obliged to acknowledge its uselessness. I could not, however, dismiss it entirely, but concluded to investigate for myself at headquarters. With this end in view I visited Hamburg during the month of May, 1905, at which time it was my privilege to witness at Professor Dunbar's hands conclusive experiments. These were the more convincing because of the subject experimented on—myself. (Experience reported in<i>Colorado Medicine</i>
Are individuals born as twins at a higher risk of developing Crohn's disease?
Authors: J Zlotogora, D Rachmilewitz
Journal: Gut (1989)

this study is that the tests used did not pick up any latent abnormality of anorectal function in the con- tinent diabetics.In these studies the only objective finding was that of reduced internal sphincter pressure in the anal canal measured by manometer.Conscious appreciation of rectal distension is a highly unreliable test.6In our study, we found that thresholds of rectal disten- sion could not detect differences between normal subjecfs, diabetics, or patients with faecal incon- tinence.None of the above papers have helped in defining the pathogenesis of faecal incontinence in diabetic subjects.They suggest that the cause is either internal anal sphincter dysfunction, external anal sphincter dysfunction or decreased awareness to rectal distension, or perhaps combinations of the above.In our study we have used precise, repeatable7 and objective measurement of sensory and motor function of anorectal physiology, which has deline- ated previously unknown asymptomatic abnormal- ities in the pelvic floor of patients with diabetic neuropathy.This combined with the fact that the diabetic population are at risk of faecal incontinence' and that idiopathic faecal incontinence is commonly associated with pelvic floor neuropathy suggests that progression of pelvic floor neuropathy in diabetic subjects may lead to faecal incontinence.We still maintain, however, that this view will only be confirmed by a further study of a group of incontinent diabetics using the same techniques.
Indian researchers look into vaccine's effectiveness as 300 die in encephalitis outbreak
Authors: Ganapati Mudur
Journal: BMJ (2007)

Health authorities in India are trying to determine the cause of an outbreak of paediatric encephalitis in the northern state of Uttar Pradesh, where the government vaccinated susceptible children last year with a Chinese made vaccine against Japanese encephalitis.

The outbreak this year has affected several thousand children and killed at least 300 over the past few weeks. Doctors have said that only about 15% of the cases have been confirmed as Japanese encephalitis and that the illness in the rest of the children seems to be another form of viral encephalitis.

But the Indian Council …
Identifying Pneumocystis carinii in Pleural Effusions
Authors: Jose Joseph
Journal: Annals of Internal Medicine (1993)

Letters15 December 1993Identifying Pneumocystis carinii in Pleural EffusionsJose Joseph, MD, Charlie Strange, MD, and Steven A. Sahn, MDJose Joseph, MDSearch for more papers by this author, Charlie Strange, MDSearch for more papers by this author, and Steven A. Sahn, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-12-199312150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The patient described by Dr. Ruskin should be viewed in the perspective of other extrapulmonary foci of Pneumocystis carinii that have included pleural-based masses, pleural effusions, and ascites [1]. Although P. carinii and Toxoplasma gondii[2] have been seen on routine cytopathologic analysis of pleural fluid, no diagnosis in our series was made cytopathologically.References1. Abati AD, Opitz L, Brones C, Burstein DE, Gallo L. Cytology of extrapulmonary Pneumocystis carinii infection in the acquired immunodeficiency syndrome. Acta Cytol. 1992; 36:440-4. Google Scholar2. Schnapp LM, Geaghan SM, Campagna A, Fahy J, Steiger D, Ng V, et al. Toxoplasma gondii pneumonitis in patients infected with the human immunodeficiency virus. Arch Intern Med. 1992; 152:1073-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1993Volume 119, Issue 12Page: 1222KeywordsAscitesPleural effusionPneumocystisToxoplasma gondii Issue Published: 15 December 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
905. Hydrodynamic Injection of Helper-Dependent Adenoviral Vectors Increases Liver Transduction Efficiency and Decreases Acute Inflammatory Response
Authors: Nicola Brunetti-Pierri, Viraj Mane, Donna Palmer, Arthur Beaudet, Milton Finegold, Philip Ng
Journal: Molecular Therapy (2005)

Hydrodynamic injection of helper-dependent adenoviral vectors (HDAd) in mice results in increased hepatic transduction resulting in higher levels of long-term transgene expression compared to conventional injection. Furthermore, hydrodynamic injection resulted in reduced splenic and pulmonary transduction and reduced serum levels of the proinflammatory cytokines IL-6 and IL-12. Interestingly, hydrodynamic injection does not appear to alter Kupffer cell uptake of the vector compared to conventional injection. Taken together, these results strongly suggest that hepatic transduction by HDAd, at least alone, does not necessarily provoke a severe innate inflammatory response, but that systemic vector dissemination may play a major role in the severity of the innate inflammatory response. These results further suggest that the safety and efficacy of HDAd-mediated, liver-directed gene therapy may be improved if the vector could be preferentially, if not exclusively, targeted to hepatocytes.
Monovalent Oral Poliovirus Vaccines — A Good Tool but Not a Total Solution
Authors: Ellie Ehrenfeld, Konstantin Chumakov
Journal: New England Journal of Medicine (2008)

The polio eradication campaign initiated in 1988 by the World Health Organization (WHO) led to an impressive decline in cases of paralytic poliomyelitis around the world. The eradication strategy involved highly organized mass immunization campaigns, relying solely on the trivalent oral polio vaccine developed by Albert Sabin and licensed in the United States in 1963. Monovalent versions of oral polio vaccine had been licensed earlier but were abandoned in favor of the trivalent combination oral polio vaccine to simplify immunization schedules. Efficacy was not considered to be a significant issue, and differences between monovalent and trivalent vaccines were never formally . . .
Monitoring the safety of over the counter drugs.
Authors: G N Volans
Journal: BMJ (1987)

Monitoring the safety of over the counter drugs Non-prescription medicines are receiving more attention because they offer a means of containing health care costs.On the one hand, the number of drugs available on prescrip- tion is being reduced by "negative product lists" -as in West Germany, the Netherlands, and Britain-while, on the other hand, new licences are being granted for over the counter drugs.The influences of these changes could be profound and should be monitored.In West Germany, for instance, introducing a negative list in 1983 was followed by a 25% increase in sales of over the counter products, while the number of people prepared to treat themselves for colds and flu doubled.'These changes are so recent that we do not know their effects on drug efficacy and safety, but these aspects must not be neglected.2The data submitted to the licensing authority on the premarket testing of over the counter drugs should be of the same quality or even better than that for prescription drugs.This is now the case for new over the counter products in Britain, but it has not always been so.The older products that were granted product licences of right are now being reviewed by the Committee for the Review of Medicines.In the latest report the committee shows that of 39 000 products originally granted licences, 22 000 have been withdrawn voluntarily or because they were unacceptable to the licensing authority, while only 1000 have been granted full licences.'4Of the 10 000 further products planned for review by 1990, 6000 are available over the counter, including 700 herbal products.The safety profile of drugs that change from being available only on prescription to being available over the counter cannot be assumed to remain unchanged.Over the counter drugs are likely to be used in low doses by healthier people with short term ailments-and so the risk of adverse drug reactions is lower.But the contraindications to the drug may be ignored, particularly by those using them long term or giving them to children.The potential for drug interactions may also increase.Underreporting of adverse drug reactions is likely since the over the counter product may not be recognised or recorded by the doctor, and minor reactions may be ignored by both patient and doctor or wrongly ascribed to a prescription medicine.Even serious adverse drug reactions are more likely to be underreported for over the counter medicines.Another risk is that self medication may result in avoidable morbidity or even mortality because of delay in seeing a doctor.
2011 IL28B POLYMORPHISM IS SIGNIFICANTLY CORRELATED WITH IFN ANTI-VIRAL EFFECTIVENESS ALREADY ON FIRST DAY OF PEGYLATED INTERFERON-α AND RIBAVIRIN THERAPY OF CHRONIC HCV INFECTION
Authors: A. Neumann, S. Bibert, B. Haagmans, A. Soulier, F. Negro, M. Lagging, C. Ferrari, S. Zeuzem, J.-M. Pawlotsky, S. Schalm, P.-Y. Bochud
Journal: Journal of Hepatology (2010)
Enhancement of potassium-sensitive current in heart cells by pinacidil. Evidence for modulation of the ATP-sensitive potassium channel.
Authors: J P Arena, R S Kass
Journal: Circulation Research (1989)

Pinacidil belongs to a novel group of compounds that enhance the potassium permeability of vascular smooth muscle. Evidence also exists that this drug enhances the potassium permeability of cardiac tissue. The purpose of the present investigation was to determine if pinacidil alters potassium-channel activity in heart and, if so, which potassium channel is the target. We used the whole-cell arrangement of the patch voltage clamp to record membrane currents from isolated guinea pig ventricular cells. In solutions designed to isolate potassium currents, pinacidil enhances a time-independent current positive to the potassium equilibrium potential. Current measured at voltages negative to the potassium equilibrium potential are essentially unaltered by the drug. The potassium sensitivity of outward current indicates that the target for the drug is a potassium channel. Experiments designed to test for voltage-dependent channel gating strongly suggest that the pinacidil-sensitive current is not voltage gated. Pinacidil-sensitive current is blocked by externally applied Ba2+, Cs+, and tetraethylammonium ion. In addition, it is potently blocked after external application of 100 nM glibenclamide. Taken along with the time- and voltage-independent properties of pinacidil-sensitive current, this pharmacology strongly suggests that the target for pinacidil in heart is the ATP-sensitive potassium channel.
Fatal Poisoning From Sodium Phosphate Enema
Authors: Robert R. Martin
Journal: JAMA (1987)

An overdose of a common over-the-counter sodium phosphate enema solution was fatal in an infant. The marked hypernatremia, acidemia, hyperphosphatemia, and hypocalcemia observed before death were also produced in a porcine model. A study using pigs showed that the enema solution was lethal if retained in doses above 20 mL/kg, equivalent to four pediatric-sized enemas in a 2-year-old child. Even normal doses of the enema solution caused measurable changes in serum phosphorus and calcium levels.
Hooked: Ethics, the Medical Profession, and the Pharmaceutical Industry
Authors: Bernd Wollschlaeger
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Determinants of coronary sinus noradrenaline in patients with ischaemic heart disease: Coronary sinus catecholamine concentration in relation to arterial catecholamine concentration, pulmonary artery oxygen saturation and left ventricular end-diastolic pressure.
Authors: J. F. HANSEN, N. J. CHRISTENSEN, B. HESSE
Journal: Cardiovascular Research (1978)

Arterial and coronary sinus noradrenaline (NA) and adrenaline (A) concentrations, cardiac output, pulmonary artery oxygen saturation (PAO2), coronary sinus oxygen saturation, left ventricular end-diastolic pressure (LVEDP), and arterial pressure were examined in 21 patients with ischaemic heart disease at rest and during exercise before and after intravenous propranolol. The heart had a net uptake of A and a net release of NA. It can be estimated that at least 50% of NA in the coronary sinus derived from the heart. NA in the coronary sinus and in the arterial blood originated therefore, at least partially, in different tissues. The NA concentration showed close correlation with PAO2, but not with cardiac index or arterial blood pressure. Multiple regression analysis also revealed a relationship between LVEDP and arterial and coronary sinus NA independent of PAO2. A very close correlation between arterial and coronary sinus NA (r = 0.93, P less than 0.001) indicates that they are largely controlled by the same factors.
Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis
Authors: Ioannis Virlos, Emanuela Mazzon, Ivana Serraino, Tiziana Genovese, Rosanna Di Paola, Christoph Thiemerman, Ajith Siriwardena, Salvatore Cuzzocrea
Journal: Intensive Care Medicine (2004)