Linezolid: The First Oxazolidinone Antimicrobial
Authors: David L. Paterson, A. William Pasculle, Kenneth McCurry
Journal: Annals of Internal Medicine (2003)

Letters18 November 2003Linezolid: The First Oxazolidinone AntimicrobialDavid L. Paterson, MBBS, FRACP, A. William Pasculle, ScD, and Kenneth McCurry, MDDavid L. Paterson, MBBS, FRACPFrom University of Pittsburgh Medical Center; Pittsburgh, PA 15213.Search for more papers by this author, A. William Pasculle, ScDFrom University of Pittsburgh Medical Center; Pittsburgh, PA 15213.Search for more papers by this author, and Kenneth McCurry, MDFrom University of Pittsburgh Medical Center; Pittsburgh, PA 15213.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-10-200311180-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In his excellent review of the new antibiotic linezolid (1), Dr. Moellering notes the recent emergence of resistance of S. aureus to linezolid. At the time the review was written, resistance had been detected in only 1 patient (2, 3). We describe an additional case of linezolid-resistant S. aureus infection in which failure of anti-staphylococcal therapy led to death of the patient.A 49-year-old man underwent single lung transplantation for silicosis. Eleven months after transplantation, the patient developed increasing dyspnea that necessitated hospitalization and mechanical ventilation. Two days later, radiography of the chest showed bilateral consolidation. Cultures ...References1. Moellering RC. Linezolid: the first oxazolidinone antimicrobial. Ann Intern Med. 2003;138:135-42. [PMID: 12529096] LinkGoogle Scholar2. Tsiodras S, Gold HS, Sakoulas G, Eliopoulos GM, Wennersten C, Venkataraman L, . Linezolid resistance in a clinical isolate of Staphylococcus aureus [Letter]. Lancet. 2001;358:207-8. [PMID: 11476839] CrossrefMedlineGoogle Scholar3. Pillai SK, Sakoulas G, Wennersten C, Eliopoulos GM, Moellering RC, Ferraro MJ, . Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype. J Infect Dis. 2002;186:1603-7. [PMID: 12447736] CrossrefMedlineGoogle Scholar4. Wilson P, Andrews JA, Charlesworth R, Walesby R, Singer M, Farrell DJ, . Linezolid resistance in clinical isolates of Staphylococcus aureus [Letter]. J Antimicrob Chemother. 2003;51:186-8. [PMID: 12493812] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: David L. Paterson, MBBS, FRACP; A. William Pasculle, ScD; Kenneth McCurry, MDAffiliations: From University of Pittsburgh Medical Center; Pittsburgh, PA 15213. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLinezolid: The First Oxazolidinone Antimicrobial Robert C. Moellering Jr. Linezolid: The First Oxazolidinone Antimicrobial Robert C. Moellering Jr. Linezolid: The First Oxazolidinone Antimicrobial James R. Johnson Linezolid: The First Oxazolidinone Antimicrobial D. A. Lindley Metrics Cited byDesigning strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapyLinezolid Resistance in Enterococcus faecalis Associated With Urinary Tract Infections of Patients in a Tertiary Hospitals in China: Resistance Mechanisms, Virulence, and Risk FactorsNew antituberculous drugs derived from natural products: current perspectives and issues in antituberculous drug developmentMacrolide, Lincosamide, Streptogramin, Ketolide, and Oxazolidinone ResistanceMicrobiology of drugs for treating multiply drug-resistant Gram-positive bacteriaEmerging Options for Treatment of Invasive, Multidrug-Resistant Staphylococcus aureus InfectionsAn infection with linezolid-resistant S. aureus in a patient with left ventricular assist systemEpidemiological Profile of Linezolid‐Resistant Coagulase‐Negative StaphylococciRole of linezolid in the treatment of complicated skin and soft tissue infectionsClinical Characteristics of Linezolid-Resistant Staphylococcus aureus InfectionsMechanisms of Resistance of Bacteria Causing Ventilator-Associated PneumoniaAntimicrobial Resistance to Linezolid 18 November 2003Volume 139, Issue 10Page: 863-864KeywordsAntibiotic resistanceAntibioticsBloodMethicillin-resistant staphylococcus aureusPneumoniaThoraxTransplantationUpper respiratory tract infectionsVancomycinVentilators ePublished: 18 November 2003 Issue Published: 18 November 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...