A New Drug (566C80) for the Treatment of <i>Pneumocystis carinii</i> Pneumonia
Authors: Walter T. Hughes
Journal: Annals of Internal Medicine (1992)

Editorials1 June 1992A New Drug (566C80) for the Treatment of Pneumocystis carinii PneumoniaWalter T. Hughes, MDWalter T. Hughes, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-11-953 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWithout treatment,Pneumocystis cariniipneumonia is almost always fatal in the immunocompromised host. Two drugs, trimethoprim-sulfamethoxazole and pentamidine isethionate, are currently the only drugs approved by the Food and Drug Administration (FDA) for the treatment of this infection. The drugs are equally effective and achieve therapeutic success in at least 75% of cases. Although these two drugs are important in the treatment ofP. cariniipneumonia, they fall short as ideal therapeutic agents. More than 50% of patients with the acquired immunodeficiency syndrome (AIDS) have adverse reactions to either of the drugs (1). Also, neither drug eradicatesP. carinii, exerting...References1. SattlerCowanNielsenRuskin FRDJ. Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of P. carinii pneumonia in the acquired immunodeficiency syndrome. Ann Intern Med. 1988;109:280-7. LinkGoogle Scholar2. FryHudsonRandallWilliams MAAR. Potential and selective hydroxynaphthoquinone inhibitors of mitochondrial electron transport in Eimeria tenella (Apicomplexa: Coccidia). Biochem Pharmacol. 1984;33:2115-22. CrossrefMedlineGoogle Scholar3. HudsonRandallFryGingerHillLatter AAMCBV. Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity. Parasitology. 1985;90:45-55. CrossrefMedlineGoogle Scholar4. HughesGrayGutteridgeLatterPudney WVWVM. Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis. Antimicrob Agents Chemother. 1990;34:225-8. CrossrefMedlineGoogle Scholar5. HughesKennedyShenepFlynnHetheringtonFullen WWJPSG. Safety and pharmacokinetics of 566C80, a hydroxynaphthoquinone with anti-Pneumocystis carinii activity: a phase I study in human immunodeficiency virus (HIV)-infected men. J Infect Dis. 1991;163:843-8. CrossrefMedlineGoogle Scholar6. FalloonKovacsHughesO'NeillPolisDavey JJWDMR. A preliminary evaluation of 566C80 for the treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1991;325:1534-8. CrossrefMedlineGoogle Scholar7. DohnFrameBaughmanHughesLaFonSmulian MPRWSA. Extended 566C80 therapy for Pneumocystis carinii pneumonia in AIDS patients. Abstract WS104, 44th Meeting of the Society of Protozoologists, Bozeman, MT, July 2, 1991. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Jude Children's Research Hospital Memphis, TN 38105 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRetinal Disease in HIV-infected PatientsRisks and benefits of aerosolized pentamidine and cotrimoxazole in primary prophylaxis of Pneumocystis carinii pneumonia in HIV-1-infected patients: a two-year Italian multicentric randomized controlled trialActivity of oral atovaquone alone and in combination with antimony in experimental visceral leishmaniasisAntipneumocystis activity of 17C91, a prodrug of atovaquonePrimary Prophylaxis against Opportunistic Infections in Patients with AIDSMedical and Virological Aspects of Ocular Human Immunodeficiency Virus Infection for the OphthalmologistClinical Experience With Atovaquone: A New Drug for Treating Pneumocystis carinii PneumoniaHigh-performance liquid chromatographic assay for the measurement of atovaquone in plasmaAtovaquone — a novel broad-spectrum anti-infective drugPneumocystis carinii Pneumonia: Treatment and Prevention 1 June 1992Volume 116, Issue 11Page: 953-954KeywordsAIDSAdverse reactionsChildrenDrug administrationDrugsFallsFood and Drug AdministrationInfectious diseasesPneumocystis carinii pneumoniaPneumonia Issue Published: 1 June 1992 PDF downloadLoading ...