tbuckley/cabot-search huggingface dataset:
Lipoprotein(a) Levels in the Nephrotic Syndrome
Authors: Christoph Wanner
Journal: Annals of Internal Medicine (1994)

Letters15 January 1994Lipoprotein(a) Levels in the Nephrotic SyndromeChristoph Wanner, MD and Werner Bartens, MDChristoph Wanner, MDUniversity Hospital of Freiburg; Freiburg 79106; GermanySearch for more papers by this author and Werner Bartens, MDUniversity Hospital of Freiburg; Freiburg 79106; GermanySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-2-199401150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Hyperlipoproteinemia of the nephrotic syndrome is multifactorial. It is generally agreed that hepatic synthesis of lipoproteins is increased (overproduction), whereas removal of lipoproteins, chylomicrons, very-low-density lipoprotein, and intermediate density lipoprotein is reduced (delayed catabolism). The precise mechanisms of increased lipogenesis and decreased lipid catabolism and their relations to urinary protein loss, hypoalbuminemia, and reduced serum oncotic pressure remain controversial. Overproduction and delayed catabolism affect almost all classes of lipoproteins, altering their concentration, composition, and metabolic rate [1].Drs. Craig and Ritchie suggest another potential factor, the physical properties of Lp(a), which may contribute to the elevated Lp(a) levels ...References1. Warwick GL, Packard CJ. Lipoprotein metabolism in the nephrotic syndrome. Nephrol Dial Transplant. 1993; 8:385-96. Google Scholar2. Oida K, Takai H, Maeda H, Takahashi S, Shimada A, Suzuki J, et al. Apolipoprotein(a) is present in urine and its excretion is decreased in patients with renal failure. Clin Chem. 1992; 38:2244-8. Google Scholar3. Sato H, Saturo S, Ueno M, Shimada H, Karasawa R, Nishi SI, et al. Localisation of apolipoprotein(a) and B-100 in various renal diseases. Kidney Int. 1993; 43:430-5. Google Scholar4. Kaysen GA, Don B, Schambelan M. Proteinuria, albumin synthesis and hyperlipidemia in the nephrotic syndrome. Nephrol Dial Transplant. 1991; 6:141-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: University Hospital of Freiburg; Freiburg 79106; Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1994Volume 120, Issue 2Page: 165-166KeywordsAttentionBloodCatabolismLipidsLipoproteinsProteinuriaRenal diseasesSerum albuminSerum proteinsUrine ePublished: 15 August 2000 Issue Published: 15 January 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Missing emotions: The <i>Z-</i>axis of collective behavior
Authors: Alejandro N. García, José M. Torralba, Ana Marta González
Journal: Behavioral and Brain Sciences (2014)

Abstract Bentley et al. bypass the relevance of emotions in decision-making, resulting in a possible over-simplification of behavioral types. We propose integrating emotions, both in the north–south axis (in relation to cognition) as well as in the west–east axis (in relation to social influence), by suggesting a Z -axis, in charge of registering emotional depth and involvement.
Nitrous Oxide-Oxygen Sedation
Authors: Robert B. Spooner
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The use of nitrous oxide-oxygen sedation in a pediatric office described by Griffin et al (1981; 245:2411) includes many important safety precautions, especially the recommendations to use equipment designed for safety and to ensure its proper installation. These measures will help protect the patient; however, there was no mention of risks to the emergency room staff from long-term exposure to nitrous oxide. With delivery rates of up to 6 L/min discharged into a treatment room, even with the recommended six air changes per hour, atmospheric pollution by nitrous oxide reaches high levels. A sample calculation for a typical emergency room, with six air changes per hour and a procedure involving 3 L/min of nitrous oxide flow for four minutes' induction followed by a 20-minute procedure, resulted in a calculated nitrous oxide concentration of 780 ppm. This is more than 30 times the National Institute of Occupational Safety
Should Heart Failure and Atrial Fibrillation be Considered in Determining the Risk of Noncardiac Surgery?
Authors: Aldo P. Maggioni
Journal: Circulation (2011)

A history of coronary artery disease has long been considered as a predictor of a higher postoperative risk after noncardiac surgery.[3] Article see p 289Much less evidence is available on the predictors of noncardiac postoperative risk related to a diagnosis of heart failure for at least 2 reasons: (a) the weak definition of documented heart failure common in most studies, and (b) the relatively low number of events on which the evidence is based.Atrial fibrillation has been considered even less, and very scarce information is available on the role of this frequent arrhythmia in predicting the postoperative risk of noncardiac surgery.This lack of evidence is particularly relevant because both clinical conditions-heart failure 4 -8 and atrial fibrillation, even more so, 9 -12 -are increasing in prevalence, determining a relevant burden on healthcare systems.Specifically, with increasing age and the improvement of treatments of acute coronary syndromes, heart failure is the most frequent cause of hospitalization in both the United States and Europe today.Although atrial fibrillation is less severe in terms of mortality and morbidity than heart failure, it is now the arrhythmia most frequently seen in clinical practice and is not without adverse consequences.The article by van Diepen et al 13 has the merit of focusing attention on the impact that these 2 relevant clinical conditions can have in terms of short-term mortality after major and minor noncardiac interventions.For this purpose, the authors used administrative databases from Alberta, Canada, that included hospital discharge, survival, and ambulatory care information.The authors showed that patients with both nonischemic and ischemic heart failure or those with atrial fibrillation had worse postoperative 30-day mortality than patients with coronary artery disease, but without these conditions.More specifically, patients with heart failure had a worse outcome even after a minor surgical intervention such as colonoscopy, cataract, or cystoscopy.Furthermore, the risk was particularly high in patients undergoing a surgical procedure in the 4 weeks that follow an index admission for heart failure or atrial fibrillation.This observation could be the basis for suggesting a longer period of stabilization after an admission, specifically in patients with heart failure, before planning an even minor elective noncardiac intervention.
Newborn Screening for Severe Combined Immunodeficiency (SCID) Leads to Early Identification of Ataxia-Telangiectasia (AT) Complicated By Neutropenia: A Case Report
Authors: Tara Shankar, Xiaohua Chen, Paul Szabolcs, Mark T. Vander Lugt, Hey J. Chong
Journal: Journal of Allergy and Clinical Immunology (2015)
Abstract A61: Dissecting the molecular basis of Ewing's sarcoma metastasis
Authors: Sun Choo, Jing Yang
Journal: Cancer Research (2014)

Abstract Ewing's sarcoma family of tumors is a group of poorly differentiated malignant pediatric cancers of bone and soft tissue. About 25% of patients present with clinically detectable metastases. Despite aggressive therapy, little improvement has been seen in patients with metastatic disease due to the lack of understanding of the molecular pathways that regulate its spread. There has been immunohistologic and gene expression profiling analyses indicating a striking similarity between Ewing's sarcoma and fetal and neuronal tissues. We hypothesize that a group of genes that regulate a specialized group of embryonic stem cells (neural crest cells) are reactivated to allow Ewing's sarcoma cells to metastasize. We examined primary human Ewing's sarcoma samples to detect the expression of one of those genes, the Twist1 transcription factor. Twenty Ewing's sarcoma samples were strongly positive for Ewing's sarcoma marker CD99, confirming the correct tumor type. Interestingly 88% (8/11) of metastatic Ewing's sarcoma patients had strong nuclear staining of Twist1 by immunohistochemistry (IHC). In contrast, only 17% (1/6) of non-metastatic tumor samples showed positive Twist1 signals, thus indicating that expression of Twist1 is tightly associated with metastasis in Ewing's sarcoma (P &amp;lt;0.05). Notably Twist1 positivity is also an independent prognostic marker for poor survival in this group of patients. 7 out of the 8 (88%) Twist1 positive patients died from disease versus only 2 out of 8 (25%) in the Twist1 negative patients (p &amp;lt; 0.05). In addition we explored PDGFRα as a possible target for therapy given that PDGFRα is a direct transcription target of Twist1. Indeed PDGFRα expression was significantly associated with Twist1 and also tightly linked to survival (P&amp;lt;0.05) in these patients. In summary, these results suggest that reactivation of the neural crest migration program through Twist1 plays a critical role in promoting metastasis in Ewing's sarcoma. Functional studies on the role of Twist1 and PDGFRα in Ewing's sarcoma metastasis are ongoing and may lead to targeted therapies against this unique developmental pathway to combat Ewing's sarcoma metastasis. Citation Format: Sun Choo, Jing Yang. Dissecting the molecular basis of Ewing's sarcoma metastasis. [abstract]. In: Proceedings of the AACR Special Conference on Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes; Nov 3-6, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;74(20 Suppl):Abstract nr A61.
On Disease of the Internal Ear: Extending to the Brain
Authors: J. Toynbee
Journal: BMJ (1852)

DISUASE OP TIRE INTZ'XAL EAR.stronger solution than they can be used as lotions, hastens the removal of the thickening of the tissues.Frequently the employment of one substance in strong solution, whilst using another as a vaginal lotion, is more beneficial than the employment of either of these substances alone.9, Langlham Plase.
Mycobacteriophage in Crohn's disease
Authors: K. Parent, I. D. Wilson
Journal: Gut (1971)

Numerous similarities between Crohn's disease and sarcoidosis are being reported. Because of previous findings of culturable mycobacteriophage in the serum of many patients with sarcoidosis, mycobacteriophages were sought in serum of patients with Crohn's disease. No difference was found in the frequency of positive cultures between patients with Crohn's disease and normal control subjects.
Hemodynamic Responses to Graded Treadmill Exercise in Young Untreated Labile Hypertensive Patients
Authors: ARTHUR M. LEVY, BURTON S. TABAKIN, JOHN S. HANSON
Journal: Circulation (1967)

Twenty labile hypertensive patients and their age-matched controls were studied at rest and during five levels of treadmill exercise. Intra-arterial blood pressure, cardiac output, and various aspects of the pressure pulse wave were analyzed under these conditions. Exercise provoked diastolic hypertension in 30% of the patient group. Mean group pressure responses demonstrated an almost constant differential through all phases of the study. The validity of a previously suggested classification of labile hypertensive subjects based on resting cardiac output estimations is questioned. A differentiation of modes of adjustment to an increased pressure load was suggested from exercise measurements of arterial ejection time. Despite numerous factors affecting the measurement, first derivative of the peripheral arterial pulse correlated well with indices of ejection time and mean rate of left ventricular ejection.
The Rheumatoid Factor and Its Significance
Authors: Nanna Svartz
Journal: JAMA (1961)

IT HAS OFTEN been discussed whether rheumatoid arthritis (RA) is a disease<i>sui generis</i>and whether there is any symptom or lesion specific to it. In a far-advanced stage, RA often has so characteristic a complex of symptoms as to be diagnosable at a glance. Especially typical are the changes in the metacarpophalangeal joints, with crookedness and ulnar deviation of the fingers. The symmetry of the articular lesions makes the ailment all the more recognizable in a fully developed stage. This gives the impression of a specific disease merely from a physical examination; atypical cases are by no means uncommon, however. I have had great difficulty in making an early diagnosis in some cases, the early symptoms of which resembled flatfoot or unilateral affection of the knee joint. In such cases it has usually been the sheepcell test which has clarified the situation. <h3>Granulomas in Collagen Diseases</h3> Various laboratory
Enhanced <i>RASGEF1A</i> Expression Is Involved in the Growth and Migration of Intrahepatic Cholangiocarcinoma
Authors: Katsuaki Ura, Kazutaka Obama, Seiji Satoh, Yoshiharu Sakai, Yusuke Nakamura, Yoichi Furukawa
Journal: Clinical Cancer Research (2006)

Abstract Purpose and Experimental Design: To identify novel molecular targets for the treatment of intrahepatic cholangiocarcinoma (ICC), the second most common type of primary hepatobiliary cancer, we earlier analyzed genome-wide expression profiles of genes in 25 ICCs. Among the genes whose expression levels were commonly elevated in the tumors, we identified a novel gene termed RASGEF1A that encodes a putative Ras guanine nucleotide exchange factor domain-containing protein. Results: We showed in this article that RASGEF1A protein has a guanine nucleotide exchange activity to K-RAS, H-RAS, and N-RAS proteins in vitro. Consistently, exogenous RASGEF1A expression increased the activity of Ras. In addition, suppression of RASGEF1A by small interfering RNA retarded the growth of cholangiocarcinoma cells. Interestingly, COS7 cells expressing exogenous RASGEF1A showed enhanced cellular motility in Transwell and wound-healing assays. Conclusions: These data suggest that elevated expression of RASGEF1A may play an essential role for proliferation and progression of ICC. Our data indicate that RASGEF1A may be a promising therapeutic target for the majority of ICCs.
Human granulocyte/pollen-binding protein. Recognition and identification as transferrin.
Authors: S P Sass-Kuhn, R Moqbel, J A Mackay, O Cromwell, A B Kay
Journal: Journal of Clinical Investigation (1984)

Normal human serum was found to contain a heat-stable protein which promoted the binding of granulocytes to timothy grass pollen (granulocyte/pollen-binding protein [GPBP]). GPBP was purified by gel filtration, anion exchange, and affinity chromatography. Virtually all of the granulocyte/pollen-binding activity was associated with a beta-1-protein having a molecular mass of approximately 77,000 D and an isoelectric point of between 5.5 and 6.1. By immunoelectrophoresis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the protein was identified as transferrin. Monospecific antisera raised against either GPBP or transferrin removed biological activity from GPBP preparations, and GPBP and transferrin gave lines of identity with these two antisera. The apparent heterogeneity in the molecular size and charge of GPBP observed during progressive purification was minimal when GPBP was saturated with ferric ions before the separation procedures. These experiments indicate that granulocyte/pollen binding is a hitherto unrecognized property of transferrin which appears to be unrelated to iron transport and raises the possibility that transferrin might have a physiological role in the removal of certain organic matter.
Echocardiographic Estimates of Pulmonary Artery Wedge Pressure
Authors: Joseph Askenazi, David I. Koenigsberg, Jack H. Ziegler, Michael Lesch
Journal: New England Journal of Medicine (1981)

IN patients free of pulmonary venous occlusive disease or mitral-valve obstructive disease or both, the pulmonary artery wedge pressure reflects the left atrial pressure and thus the left ventricular filling pressure. Care of a critically ill patient with a cardiac disorder frequently requires measurement of the pulmonary artery wedge pressure by right-heart catheterization with a balloon-tipped flow-directed catheter. Bedside catheterization of the right heart is an expensive procedure with a small but definite risk.1 An easily obtained and reproducible noninvasive method of assessing left ventricular pressure, using only the electrocardiogram and the echocardiogram, is described below.Phonocardiographic studies in patients . . .
Book Review The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery Second edition. Edited by Hans Beger, Andrew Warshaw, and Markus Büchler, with five others. 1006 pp., illustrated. Malden, MA, Wiley–Blackwell, 2008. $489.95. 978-1-4051-4664-7
Authors: Julia B. Greer
Journal: New England Journal of Medicine (2009)
The Greek experience with efalizumab in psoriasis from a University Dermatologic Hospital
Authors: C. Antoniou, I. Stefanaki, A. Stratigos, G. Avgerinou, P. Stavropoulos, I. Potouridou, D. Polidorou, A.E. Moustou, M. Kosmadaki, A.D. Katsambas
Journal: British Journal of Dermatology (2007)

Efalizumab (anti-CD11a antibody) targets T cell-mediated steps important in the immunopathogenesis of psoriasis. As efalizumab is intended to be administered on a continuous long-term basis in psoriasis, it is important to share experience concerning issues commonly occurring during its use in real daily practice.To evaluate the efficacy and safety of efalizumab treatment in Greek patients with moderate-to-severe plaque psoriasis, and to investigate whether there are specific characteristics that predict the clinical outcome of therapy.Seventy-two patients with moderate-to-severe plaque psoriasis, who had failed to respond to, or had a contraindication to, or were intolerant to other systemic therapies, received efalizumab (1 mg kg(-1) per week) for 12 weeks or more.After 12 weeks of efalizumab treatment, 65% of patients achieved 50% or more improvement from baseline Psoriasis Area and Severity Index (PASI) and 39% achieved at least 75% reduction in PASI score. The mean percentage PASI improvement from baseline was 62%. The most common side effects were a flu-like syndrome, a transient localized papular eruption, leucocytosis and lymphocytosis. There was no correlation between the occurrence of these side effects and the clinical response. Patients with a past history of unstable types of psoriasis were likely poor responders to efalizumab, and at an increased risk of developing generalized inflammatory flare.These results confirm previous reports suggesting that treatment with efalizumab is an efficacious and safe option for patients with moderate-to-severe plaque psoriasis. A detailed previous history of psoriasis is important in order to select possible candidates for efalizumab therapy.
Long-term Diazepam Therapy-Reply
Authors: Karl Rickels
Journal: JAMA (1984)

<h3>In Reply.—</h3> We read with interest the comments of Drs Bargmann and Wolfe concerning our article entitled "Long-term Diazepam Therapy and Clinical Outcome." We would like to respond to a couple of the points raised in this letter. As Drs Bargmann and Wolfe note, none of the 14 patients who demonstrated withdrawal symptoms in our study experienced more severe manifestations such as seizures or psychosis. It should be emphasized that the conditions of these patients were all maintained with placebo capsules for at least five to seven days during the withdrawal phase. While clear symptoms of withdrawal were observed, no severe reactions (eg, seizures or psychotic reactions) occurred. In keeping with our findings, few instances of severe withdrawal reactions associated with termination of<i>clinically accepted</i>doses of benzodiazepines have been reported in the literature. In the case reports cited by Drs Bargmann and Wolfe, the observations were made in uncontrolled
Ventilation-Perfusion Scintigraphy in Children and Adolescents Is Associated With a Low Rate of Indeterminate Studies
Authors: Michael J. Gelfand, Ralph A. Gruppo, Michael P. Nasser
Journal: Clinical Nuclear Medicine (2008)

In selected populations, ventilation-perfusion (V/Q) studies are nearly as accurate as CT angiography (CTA) for the diagnosis of pulmonary emboli (PE). This study was performed to determine the percentage of V/Q studies in children and adolescents that are indeterminate for the presence of PE.V/Q studies performed over a period of 2 years were reviewed. Studies from children and adolescents with chronic lung disease or recent documented severe PE were excluded. There were 37 V/Q studies and 3 perfusion only (Q) studies in 35 patients. Studies were evaluated using modified Biello criteria. Effective doses (EDs) for V/Q and CTA studies of the lung were calculated from administered activities and CT exposure parameters used.Eighteen studies were normal, 4 studies had a very low probability of PE, 6 were low probability, and 2 were high probability for PE. Four studies were negative for new PE when compared with a previous study. Five V/Q studies and 1 Q only study were indeterminate for PE (15%), only slightly higher than the reported percentage of indeterminate CTA in adults. ED from V/Q was about half the ED from CT angiography. Breast dose from V/Q was less than 3% of the breast dose from CT.In this selected group of children and adolescents, the percentage of indeterminate V/Q studies is low. V/Q has considerably lower absorbed breast and effective radiation doses than CTA, and is still appropriate for imaging children who are suspected of having PE.
Abstract 3203: Honokiol inhibits growth and migration of renal cell carcinoma
Authors: Shujie Cheng, Matt Welty, Isaac Eliaz, Victor Castillo, Daniel Sliva
Journal: Cancer Research (2014)

Abstract Renal cell carcinoma (RCC) is a common urological cancer worldwide and is known to the high risk of recurrence and metastasis. Approximately 70% of patients with RCC will develop recurrence after surgical resection, and 25%-30% of patients will eventually develop progression to distant metastasis. Honokiol is a small-molecule polyphenol isolated from the genus Magnolia, which has been shown to be a potential anticancer agent in multiple facets of signal transduction. Here we demonstrate that honokiol inhibits proliferation of RCC cells 786-0 and A498 without affecting cell viability. Moreover, honokiol also significantly inhibited migration of 786-0 cells in a dose-dependent manner. DNA microarray analysis showed that honokiol regulated expression of many genes related to human tumor metastasis in 786-0 cells. Real time PCR analysis confirmed that the expression of metastasis suppressor KISS1 and its receptor, KISS1R, were upregulated in 786-0 cells after treatment with honokiol. In addition, the shape changes and excessive formation of actin stress fibers were identified in 786-0 cells treated with honokiol. This phenomenon disappeared when treated cells with the pharmacological Rho-kinase inhibitor Y-27632 and honokiol. This inhibition can also be identified in 786-0 cells treated with Y-27632 only. Our present results demonstrated that honokiol could inhibit the growth and migration of RCC, which is likely to be regulated by the Rho and Rho-Associated Kinase (ROCK) pathway. In conclusion, honokiol is a biologically active natural compound which can be considered for the alternative treatment of RCC. The investigation of detailed mechanisms and molecular targets are in progress. Citation Format: Shujie Cheng, Matt Welty, Isaac Eliaz, Victor Castillo, Daniel Sliva. Honokiol inhibits growth and migration of renal cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3203. doi:10.1158/1538-7445.AM2014-3203