tbuckley/cabot-search huggingface dataset:
John Leonard Wilkins
Authors: J. Powley
Journal: BMJ (2004)

Former consultant paediatrician Eastbourne and Hastings (b 1928; q King's College Hospital, London, 1951; FRCP Ed), died on 18 February 2003 following a heart attack.​attack.




Figure 1




By the age of 13 John had lost both parents through illness, but with help from his father's employers and his godparents he gained a scholarship to Christ's Hospital School, where a love of music began. He was appointed consultant in 1971 and retired in 1988, free to continue his pursuit of classical music and opera and becoming cheerfully overweight and hypertensive. He spent repeated holidays in Austria and Mauritius to revisit old friends, and perhaps to compensate for bachelor life in a small flat.
Resident Forum
Authors: M. A. (Tonette) Krousel-Wood
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of atopic dermatitis with mycophenolate mofetil
Authors: E.R. Hansen, S. Buus, M. Deleuran, K.E. Andersen
Journal: British Journal of Dermatology (2000)

Journal Article Treatment of atopic dermatitis with mycophenolate mofetil Get access E.R. Hansen, E.R. Hansen Department of Dermatology, University Hospital of Odense, 5000 Odense C, Denmark *Department of Dermatology, University Hospital of Aarhus, 8000 Aarhus C, Denmark E‐mail: ehansen@dadlnet.dk Search for other works by this author on: Oxford Academic Google Scholar S. Buus, S. Buus Department of Dermatology, University Hospital of Odense, 5000 Odense C, Denmark *Department of Dermatology, University Hospital of Aarhus, 8000 Aarhus C, Denmark E‐mail: ehansen@dadlnet.dk Search for other works by this author on: Oxford Academic Google Scholar M. Deleuran, M. Deleuran Department of Dermatology, University Hospital of Odense, 5000 Odense C, Denmark *Department of Dermatology, University Hospital of Aarhus, 8000 Aarhus C, Denmark E‐mail: ehansen@dadlnet.dk Search for other works by this author on: Oxford Academic Google Scholar K.E. Andersen K.E. Andersen Department of Dermatology, University Hospital of Odense, 5000 Odense C, Denmark *Department of Dermatology, University Hospital of Aarhus, 8000 Aarhus C, Denmark E‐mail: ehansen@dadlnet.dk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 6, 1 December 2000, Pages 1324–1326, https://doi.org/10.1046/j.1365-2133.2000.03914.x Published: 01 December 2000
THIOSINAMIN IN THE TREATMENT OF ARSPHENAMIN DERMATITIS
Authors: SIGMUND S. GREENBAUM
Journal: JAMA (1924)

Although the incidence of reactions following arsphenamin medication has been greatly reduced since governmental toxicity control tests have been instituted, as well as generalization of the precautionary knowledge requisite to the injection of an arsphenamin, they still occur, despite the utmost precaution and attention to detail. Even the introduction of arsphenamins suitable for intramuscular use does not obviate their tendency to develop; indeed, the incidence of dermatitis appears to be even greater with certain of these. One of the commonest untoward reactions following arsphenamin therapy is dermatitis. An effective agent for rapidly inhibiting the progress of an arsphenamin dermatitis has long been desired, particularly of the insidious types that may end fatally. Until recently, arsphenamin dermatitis was treated more or less symptomatically. In 1920, Ravaut<sup>1</sup>observed that sodium thiosulphate appeared to exert a curative effect on experimental arsphenamin intoxication in rabbits, and that in the human subject it tended
GERMANY'S GUILT FOR INTRODUCING WAR GASES
Authors: Henry Leffmann
Journal: JAMA (1918)

<h3>To the Editor:</h3> —In an editorial inThe Journal, November 23, you refer to the suggestion that asphyxiating gases be used in warfare as having been rejected by the British government by reason of the inhumanity of the procedure. The actual facts are that at the first Hague convention in 1899, when twenty-six nations were represented, a proposal to prohibit the use of such gases was made and twenty-four nations agreed, the dissenting nations being Great Britain and the United States. In 1907, the matter was again brought up. This was the second general convention. Great Britain gave way and the United States stood alone in refusing to agree to the prohibition. The chairman of the convention—a Dutch delegate—begged Admiral Mahan—the opponent of the resolution—to sign for the sake of humanity, but he declined. His reasons for this action are given in Hull's book, "The Two Hague Conferences." They are,
Pathogenesis of Venous Thrombosis
Authors: Elias A. Husni
Journal: JAMA (1971)

To the Editor.—  The authors wish to thank Matzger for his letter Pathogenesis of Venous Thrombosis ( 215 :799, 1971). Our agreement with Matzger is complete— the problem of thromboembolism is by no means resolved. However, we do not share his opinion that this subject is cloaked in mystery. It is our firm conviction that the inability to date to control this dreaded complication in hospital patients should not be cause for despair but rather should spur us on to continuous, diligent studies and research until the ultimate conquest is achieved.  In his hurried attempt to build a case, Matzger overlooked several pertinent facts.  Unquestionable reduction of the venous pool of the calf (both deep and superficial veins) was repeatedly and amply demonstrated in our illustrations and fully explained under Phlebograms . Angiography while not entirely free from pitfalls is the choice tool available to us for the delineation of vascular forms
Abstract 4930: Quantitative PET imaging of tissue factor expression using 18F-labeled active site inhibited factor VIIa
Authors: Carsten H. Nielsen, Maria Erlandsson, Mette M. Jensen, Jacob Madsen, Lars C. Petersen, Andreas Kjaer
Journal: Cancer Research (2014)

Abstract Objectives: Tissue factor (TF) is up regulated in many solid tumors and its expression is linked to tumor angiogenesis, invasion, metastasis and prognosis. Hence it would be of clinical relevance if one could assess tumor TF expression status non-invasively. Here we report the development of a new PET tracer for specific imaging of TF using a derivative of factor VII, the natural ligand to TF, labeled with 18F. Methods: Active site inhibited factor VIIa (ASIS) was radiolabeled with N-succinimidyl 4-18F-fluorobenzoate ([18F]SFB) and purified. Nude mice (n=5) with subcutaneous human pancreatic xenograft tumors (BxPC-3) underwent small animal PET/CT imaging 1, 2 and 4 hours after injection of 7.3-9.3 MBq [18F]ASIS (∼37 µg) in 160 µL saline. Mice were euthanized following the last imaging session, and their tumors and major organs were resected for ex vivo gamma well counting. Tumor tissue was preserved for molecular analysis. A blocking experiment was performed in a second set of mice. The blocking group (n=3) received 500 µg non-labeled ASIS before injection of [18F]ASIS and was imaged after 4 hours. The expression pattern of TF in the tumors was visualized by immunohistochemistry and the amount of TF in tumor homogenates was measured by ELISA. Results: The PET images showed high uptake of [18F]ASIS in the tumor regions with a mean uptake of 2.40 ±0.18, 2.56 ±0.20 and 2.54 ±0.27 %ID/g (Mean ±SEM) at 1, 2 and 4 hours after injection of [18F]ASIS and with an average maximum uptake in the tumors of 7.08 ±0.72 %ID/g at 4 hours. In comparison, the muscle uptake was 0.19 ±0.01 %ID/g at 4 hours. At 4 hours the tumors had the highest uptake of any organ. Blocking with cold ASIS significantly reduced the uptake of [18F]ASIS from 2.51 ±0.06 to 1.29 ±0.07 %ID/g (p&amp;lt;0.001). Importantly, the uptake of [18F]ASIS measured in vivo by PET imaging correlated (r=0.72, p&amp;lt;0.02) with TF expression at the protein level measured ex vivo in tumor homogenates by ELISA. Conclusion: PET/CT imaging with [18F]ASIS can be used for specific, non-invasive imaging of TF expression. Research Support: This work was supported by at grant from the Danish National Advanced Technology Foundation. Citation Format: Carsten H. Nielsen, Maria Erlandsson, Mette M. Jensen, Jacob Madsen, Lars C. Petersen, Andreas Kjaer. Quantitative PET imaging of tissue factor expression using 18F-labeled active site inhibited factor VIIa. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4930. doi:10.1158/1538-7445.AM2014-4930
DNA methylation may be associated with health inequalities
Authors: B. Christie
Journal: BMJ (2012)

A study carried out among people living in deprived parts of Glasgow has found that they may have been imprinted at a few weeks after conception with a biological change that leads to ill health in later life.

The finding has been described as “significant” by the research team, which believes that it may help to explain some of the unanswered questions about health inequalities in the city and elsewhere.

The research focused on DNA methylation, the signalling tool that cells use to control gene expression and that is a crucial part of normal development ( International Journal of Epidemiology doi:10.1093/ije/dyr215). Most DNA methylation is fixed for life from just a few weeks after conception. Lower levels of methylation have been linked to a variety of diseases, including diabetes, cardiovascular disease, and cancer.

The researchers analysed blood samples from 239 people from Glasgow’s most deprived and …
Angioimmunoblastic lymphadenopathy-type peripheral T-cell lymphoma with cutaneous infiltration: report of a case and its gene expression profile
Authors: T. Murakami, M. Ohtsuki, H. Nakagawa
Journal: British Journal of Dermatology (2001)

Journal Article Angioimmunoblastic lymphadenopathy‐type peripheral T‐cell lymphoma with cutaneous infiltration: report of a case and its gene expression profile Get access T. Murakami, T. Murakami Department of Dermatology, Jichi Medical School, 3311‐1 Yakushiji, Minamikawachi‐machi, Kawachi‐gun, Tochigi 329‐0498, Japan Takashi Murakami. E‐mail: takmu@jichi.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Ohtsuki, M. Ohtsuki Department of Dermatology, Jichi Medical School, 3311‐1 Yakushiji, Minamikawachi‐machi, Kawachi‐gun, Tochigi 329‐0498, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Nakagawa H. Nakagawa Department of Dermatology, Jichi Medical School, 3311‐1 Yakushiji, Minamikawachi‐machi, Kawachi‐gun, Tochigi 329‐0498, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 4, 1 April 2001, Pages 878–884, https://doi.org/10.1046/j.1365-2133.2001.04150.x Published: 01 April 2001
Atrial Fibrillation While Chewing Nicotine Gum
Authors: Nancy A. Rigotti
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Since 1984, nicotine chewing gum has been widely prescribed by physicians to aid cigarette smokers attempting to give up their habit. Many smokers who could benefit from smoking cessation have cardiovascular disease. Whether they can safely use the gum has not been established, because there are no published reports of gum use in cardiac patients. We report here a man with known cardiovascular disease who developed atrial fibrillation while chewing nicotine gum. <h3>Report of a Case.—</h3> A 52-year-old male smoker with known coronary artery disease sought help in order to stop smoking. He had smoked three packs of cigarettes per day for 35 years and made several unsuccessful attempts to quit. Following coronary artery bypass surgery in 1981 he did not smoke for three years, but relapsed during a time of stress. When seen, he was smoking one pack of low-tar and nicotine cigarettes daily, had rare
25-hydroxycholecalciferol-enhanced bone maturation in the parathyroprivic state.
Authors: J E Russell, L V Avioli
Journal: Journal of Clinical Investigation (1975)

In vitro evidence presently favors a direct osteolytic effect of biologically active vitamin D metabolites. Studies were designed to evaluate the effect of 25-hydroxycholecalciferol (25OHD3) on bone collagen and mineral maturation in vivo and its dependence on parathyroid hormone (PTH). After treatment of sham-operated control and parathyroidectomized (PTX) mature rats with either 25OHD3 or an oil vehicle for 2 wk, tibial bone mineral-collagen maturation was quantitated by bromoform-toluene density gradient fractionation techniques. Intestinal calcium absorption was measured by in vivo 45Ca transport procedures. In contrast to the control group, the response to 25OHD3 of PTX rats was dramatic. Bone mineral and matrix maturation were both accelerated by 25OHD3 treatment without concomitant reduction in total bone mineral or collagen content or changes in the intestinal calcium absorption. These observations support the premise that biologically active vitamin D metabolites stimulate bone tissue maturation, and that PTH is not required in this regard.
FDA agrees to ease restrictions on emergency contraceptive
Authors: J. H. Tanne
Journal: BMJ (2009)

The US Food and Drug Administration said on 22 April that it would accept and not appeal against a New York federal court decision that 17 year old women should be able to buy the emergency contraceptive pill Plan B without a prescription.

The agency said, “In accordance with the court’s order, and consistent with the scientific findings made in 2005 by the [FDA’s] Center for Drug Evaluation and Research, FDA notified the manufacturer of Plan B informing the company that it may, upon submission and approval of an appropriate application, market Plan B to women 17 years of age and older.” 

The case was originally brought in 2005 by the Center for …
Isolation of mycobacteria from patients seropositive for the human immunodeficiency virus (HIV) in south east England: 1984-92.
Authors: M D Yates, A Pozniak, J M Grange
Journal: Thorax (1993)

Tuberculosis and other mycobacterial infections are well recognised complications of HIV infection and surveillance is thus required.All mycobacteria isolated from HIV positive subjects and referred to the Public Health Laboratory Service South East Regional Tuberculosis Centre (SERTC) from the first such case in 1984 until the end of 1992 were reviewed.A total of 803 mycobacteria isolated from 727 HIV positive subjects were referred to the SERTC during the study period. A single species was isolated from 660 patients: 150 members of the tuberculosis complex (146 M tuberculosis, two M bovis, and two M africanum), 356 M avium-intracellulare (MAI), and 154 other environmental mycobacteria. More than one mycobacterium was isolated from 67 patients. In 12 cases M tuberculosis and MAI were isolated from the same patient, almost always in that sequence, with an interval of 8-41 months between isolations. Most of the 407 isolates of MAI (74%) were considered to be clinically significant and often caused disseminated disease. In other cases single isolates of MAI were obtained from sputum or faeces and occasionally such isolates preceded disseminated disease by several months. Only 33 (14%) of the 229 isolates of environmental mycobacteria other than MAI were considered clinically significant.HIV related mycobacterial disease is increasing in incidence in south east England. Further studies are required to determine the significance of single isolates of MAI and other environmental mycobacteria as a guide to the need for preventive chemotherapy or immunotherapy.
Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice.
Authors: A Oshiba, E Hamelmann, K Takeda, K L Bradley, J E Loader, G L Larsen, E W Gelfand
Journal: Journal of Clinical Investigation (1996)

In a proportion of atopic asthmatics, exposure to a relevant antigen is followed by chronic inflammation in the airways leading to altered airway responsiveness (AR). However, the mechanisms underlying the development of airway hyperresponsiveness still remain unclear. To elucidate the relationship between IgE-mediated reactions and airway hyperresponsiveness, a murine model of passive sensitization and airway challenge with ovalbumin (OVA) was developed using anti-OVA IgE and IgG antibodies from murine B cell hybridomas. Passive sensitization by intravenous injection of anti-OVA IgE resulted in immediate cutaneous hypersensitivity and, after airway challenge with OVA on two consecutive days, increased AR in BALB/c and SJL mice. Increased numbers of eosinophils were observed in bronchoalveolar lavage fluid, in cells extracted from the lungs, and in the peribronchial areas of BALB/c mice passively sensitized with IgE and challenged through the airways compared with nonsensitized mice. Eosinophil peroxidase activity was also elevated in lung tissue from these mice. Passive sensitization with anti-OVA IgG1 but not IgG2a or IgG3 was similarly associated with development of skin test reactivity and increased AR after airway challenge, accompanied by an increase in eosinophils in bronchoalveolar lavage fluid. These data suggest that IgE/IgG1-mediated reactions together with local challenge with antigen can result in allergic inflammation resulting in altered airway function.
Evoked Cortical Potentials in Patients with Stroke
Authors: SANFORD J. LARSON, ANTHONY SANCES, JOHN B. BAKER
Journal: Circulation (1966)

The evoked somatosensory potentials recorded from 24 patients with stroke are described. The changes seen in the evoked responses can be correlated with the clinical observations during the acute phase in most instances, although improvement in sensory perception is not accompanied by a parallel recovery of evoked potential amplitude. Cerebral diaschisis may be responsible for bilateral depression of evoked somatosensory potentials in the presence of unilateral infarct.
The meddling microbes midst our medicines
Authors: VK Viswanathan
Journal: Gut Microbes (2013)

It is not surprising that the complex metabolic machinery of the gut microbiome has accidental, or directed, ability to alter our medicines and influence their efficacy. What is not known is the extent to which this has contributed to drug failures or contraindications, or to the derailment of clinical trials. Some studies are unraveling the mechanisms by which the microbiota alter specific drugs, such as digoxin, and contribute to variations in efficacies between patient populations. Microbiome profiling, therefore, may well become an inevitable arm of all clinical trials in the future.
Doctors criticise Indian Medical Association for ignoring unethical practices
Authors: G. Mudur
Journal: BMJ (2012)

Some doctors in India have decried what they say are attempts by the Indian Medical Association to deny the prevalence of unethical practices in medicine and to resist key government initiatives that are expected to improve healthcare services in the country.

The Forum for Medical Ethics Society and the Medico Friend Circle, two health groups established by doctors, have jointly called on the association’s officers to “do some genuine introspection” and tackle the problems rather than deny them.

Their appeal comes after the association earlier this month criticised a television talk show hosted by a popular “Bollywood” actor, Aamir Khan. The show had highlighted what some doctors themselves have described as unethical practices: sharing fees for referring patients to specialists, accepting gifts from drug companies, and irrational prescribing of drugs and diagnostic procedures.

“Many of us in the medical fraternity have been worried about the state of affairs,” said Sunil Kaul, convener of the Medico Friend Circle and a trustee of the Action Northeast Trust, a charitable organisation involved in community health activities in the northeastern state of Assam. “We felt it was important for doctors to support key messages that the television show tried to convey,” Kaul told the BMJ .

The …
Number of UK diabetic patients set to double by 2010
Authors: R. Dobson
Journal: BMJ (2000)

Parts of the NHS are struggling to meet the needs of patients with diabetes, and improvements are needed if services are to keep up with increasing demand, according to a review of diabetic services in England and Wales by the Audit Commission published this week.

The report, which urges that the NHS ensures that payment to GPs is linked to the activity and quality of diabetes care, says that four out of 10 general practices lack referral guidelines on diabetes.

It also says there is …
Iliopelvic Lymphoscintigraphy as a Predictor of Early Metastatic Disease in Patients with Prostate Carcinoma
Authors: D FERRER, R KLOIBER
Journal: Clinical Nuclear Medicine (1992)

Fifty-one patients had iliopelvic lymphoscintigraphy (IPL) as part of the initial assessment of newly diagnosed prostate carcinoma over a 3-year period. Investigations other than IPL showed that all patients had disease confined to the prostate, and they received radiotherapy to the prostate and regional pelvic lymph nodes. Patients with complete absence of activity in an iliac chain on IPL were excluded from the analysis because that finding could have resulted from tumor replacement or a failed injection. Of the remaining 41 patients, 12 had abnormal scintigrams, and 6 (50%) had recurrence within a mean 15-month follow-up period. Of 29 patients with normal scintigrams, 26 (90%) remain disease free over an average 27-month follow-up period.
Bisphosphonate-Associated Osteonecrosis of the Jaw
Authors: Nathaniel Treister, Sook-Bin Woo
Journal: New England Journal of Medicine (2006)

A 54-year-old man with a 3-year history of IgG myeloma, complicated by hypercalcemia, who was being treated with dexamethasone, lenalidomide, filgrastim, darbepoetin alfa, and pamidronate, presented with a 1-month history of severe bilateral jaw pain. He had no known bone involvement from his myeloma, nor did he recall any specific trauma to his jaw. Clinical examination revealed areas of exposed bone 1 to 1.5 cm in length with surrounding erythema on the posterior lingual mandible bilaterally (Panel A, lesion on the left mylohyoid ridge). A diagnosis of bisphosphonate-associated osteonecrosis of the jaw was made, and pamidronate, which he had been . . .
Reply to comment on “An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice”
Authors: Yvette I. Sheline, Tim West, Kevin Yarasheski, Mateusz S. Jasielec, Jane C. Hettinger, Danielle L. Tripoli, Chengjie Xiong, Christine Frederiksen, Monica V. Grzelak, Randall J. Bateman, John C. Morris, Jin-Moo Lee, John R. Cirrito
Journal: Science Translational Medicine (2014)

Possible reasons for why a new study could not replicate our finding that the serotonin reuptake inhibitor citalopram decreased amyloid β concentrations in the cerebrospinal fluid of healthy volunteers.