tbuckley/cabot-search huggingface dataset:
Substance, Structure, Form and Function in the Psychosomatic Phenomenon
Authors: S. Black
Journal: Psychotherapy and Psychosomatics (1972)

To explain the psychosomatic phenomenon it has been proposed on thermodynamic evidence that all biological information is eventually transmitted in terms of molecular form and that the primeval basis of mind is the informational system which results [Black, 1969, 1970]. Logical analysis now shows that the substance of inanimate matter always constrains its structure, which in turn constrains its form, to give the causal chain: substance→structure→form. Introducing the concept of function, the only rational causal chain which then explains the living chemistry is found to be: form→function→substance→structure. This conclusion supports the thermodynamic model quoted.
Recurrence of Hepatocellular Carcinoma
Authors: Morris Sherman
Journal: New England Journal of Medicine (2008)

Although the treatment of hepatocellular carcinoma is evolving, hepatic resection remains the treatment of choice for many patients. Resection is associated with a 5-year survival rate of 50% but also a 70% recurrence rate.13 Thus, for most patients, resection is not a cure. Recurrence of hepatocellular carcinoma after resection or local ablation with heat generated by high-frequency radio waves can be classified as early or late. Early recurrence occurs within weeks or months after treatment and has been attributed to either incomplete initial treatment or micrometastases within the liver but outside the treated field. Late recurrence, defined as recurrence . . .
Obstructive respiratory failure in cicatricial pemphigoid.
Authors: C R de Carvalho, M B Amato, L M Da Silva, C S Barbas, R A Kairalla, P H Saldiva
Journal: Thorax (1989)

A 20 year old woman died of respiratory failure due to cicatricial pemphigoid of the trachea and bronchi. This is the first case with the lower airways affected to be reported.
Benign Infundibular Pulmonary Stenosis with Secondary Dilatation of the Main Pulmonary Artery
Authors: George S. Husson, Marie S. Blackman, Paul Riemenschneider, Alfred S. Berne
Journal: New England Journal of Medicine (1963)

ALTHOUGH idiopathic dilatation of the main pulmonary artery had been described in several previous reports1 2 3 4 5 6 7 8 9 10 11 12 it was not until 1949 that Greene et al.13 laid down criteria for the ante-mortem diagnosis of this benign malformation. These criteria were based on clinical and hemodynamic studies. More recently Deshmukh and his associates14 presented additional data in 13 patients. Grishman and his co-workers6 described angiographic studies in 4 asymptomatic adults.We have had the opportunity of studying 17 patients and wish to add our findings to the scant literature on this benign cardiac malformation. We emphasize the fact that this anomaly is more . . .
Cost-effectiveness of different strategies to monitor adults on antiretroviral treatment: a combined analysis of three mathematical models
Authors: Daniel Keebler, Paul Revill, Scott Braithwaite, Andrew Phillips, Nello Blaser, Annick Borquez, Valentina Cambiano, Andrea Ciaranello, Janne Estill, Richard Gray, Andrew Hill, Olivia Keiser, Jason Kessler, Nicolas A Menzies, Kimberly A Nucifora, Luisa Salazar Vizcaya, Simon Walker, Alex Welte, Philippa Easterbrook, Meg Doherty, Gottfried Hirnschall, Timothy B Hallett
Journal: The Lancet Global Health (2013)

BackgroundWHO's 2013 revisions to its Consolidated Guidelines on antiretroviral drugs recommend routine viral load monitoring, rather than clinical or immunological monitoring, as the preferred monitoring approach on the basis of clinical evidence. However, HIV programmes in resource-limited settings require guidance on the most cost-effective use of resources in view of other competing priorities such as expansion of antiretroviral therapy coverage. We assessed the cost-effectiveness of alternative patient monitoring strategies.MethodsWe evaluated a range of monitoring strategies, including clinical, CD4 cell count, and viral load monitoring, alone and together, at different frequencies and with different criteria for switching to second-line therapies. We used three independently constructed and validated models simultaneously. We estimated costs on the basis of resource use projected in the models and associated unit costs; we quantified impact as disability-adjusted life years (DALYs) averted. We compared alternatives using incremental cost-effectiveness analysis.FindingsAll models show that clinical monitoring delivers significant benefit compared with a hypothetical baseline scenario with no monitoring or switching. Regular CD4 cell count monitoring confers a benefit over clinical monitoring alone, at an incremental cost that makes it affordable in more settings than viral load monitoring, which is currently more expensive. Viral load monitoring without CD4 cell count every 6–12 months provides the greatest reductions in morbidity and mortality, but incurs a high cost per DALY averted, resulting in lost opportunities to generate health gains if implemented instead of increasing antiretroviral therapy coverage or expanding antiretroviral therapy eligibility.InterpretationThe priority for HIV programmes should be to expand antiretroviral therapy coverage, firstly at CD4 cell count lower than 350 cells per μL, and then at a CD4 cell count lower than 500 cells per μL, using lower-cost clinical or CD4 monitoring. At current costs, viral load monitoring should be considered only after high antiretroviral therapy coverage has been achieved. Point-of-care technologies and other factors reducing costs might make viral load monitoring more affordable in future.FundingBill & Melinda Gates Foundation, WHO.
PI3K/mTOR Signaling in Mesothelioma Patients Treated with Induction Chemotherapy Followed by Extrapleural Pneumonectomy
Authors: Byron K.Y. Bitanihirwe, Mayura Meerang, Martina Friess, Alex Soltermann, Lukas Frischknecht, Svenja Thies, Emanuela Felley-Bosco, Ming-Sound Tsao, Ghassan Allo, Marc de Perrot, Burkhardt Seifert, Holger Moch, Rolf Stahel, Walter Weder, Isabelle Opitz
Journal: Journal of Thoracic Oncology (2014)
Small Bowel Invagination Caused by Intestinal Melanoma Metastasis
Authors: Klaus Strobel, Jeannine Skalsky, Thomas F. Hany, Reinhard Dummer, Hans C. Steinert
Journal: Clinical Nuclear Medicine (2007)

FDG-PET/CT was performed for restaging in a 46-year-old woman with a cutaneous malignant melanoma of the leg resected 4 years previously and an increasing S-100 tumor marker. Besides multiple focal lesions with increased FDG accumulation in the lungs, bone and soft tissue FDG-PET/CT images demonstrated focal FDG activity in the lower abdomen. With the CT information, the lesion could be localized in the small bowel. CT images additionally demonstrated a "crescent-in-doughnut sign" and "sandwich sign"—typical CT signs for an invagination. Four hours after the PET/CT scan, the patient developed obstructive bowel symptoms, which were treated conservatively because of the palliative tumor situation. The patient died 4 months later.
Rociletinib: an oral, irreversible, highly selective small molecule inhibitor of mutant EGFR including T790M
Authors: J.-C. Soria, L.V. Sequist, J. Goldman, H.A. Wakelee, J. Neal, R. Camidge, S. Gadgeel, V. Papadimitrakopoulou, R. Dziadziuszko, Z. Piotrowska, A. Varga, B.J. Solomon
Journal: Annals of Oncology (2015)
Relation of Antiphospholipid Antibodies to Postmortem Brain Infarcts in Older People
Authors: Zoe Arvanitakis, Robin L. Brey, Jacob H. Rand, Julie A. Schneider, Ana W. Capuano, Lei Yu, Sue E. Leurgans, David A. Bennett, Steven R. Levine
Journal: Circulation (2014)

There are few data on the relationship of antiphospholipid antibodies (aPLs) to pathologically proven brain infarcts. We tested the hypothesis that aPLs are associated with a higher odds of brain infarcts among older, community-dwelling individuals who came to autopsy.Specimens and clinical and pathological data were derived from 607 deceased subjects (mean age at death, 89 years; 66% women) who were participating in 1 of 2 cohort studies of aging (Rush Memory and Aging Project and Religious Orders Study) and had agreed to brain autopsy. Brain infarcts were identified on gross and microscopic examinations, and severity of cerebral vessel disease (atherosclerosis, arteriolosclerosis) was graded. Four clinically used aPLs were measured longitudinally: 3 in serum (anticardiolipin antibodies, β2-glycoprotein I, and anti-phosphatidyl-serine) and 1 in plasma (lupus anticoagulant). A quarter of subjects (142 of 607, 23%) had at least 1 aPL present at baseline (median time interval from baseline to death, 4.6 years), and three quarters of these subjects had persistently positive measures over time. In a logistic regression analysis, baseline aPL positivity did not increase the odds of brain infarcts (odds ratio=1.08; 95% confidence interval, 0.74-1.58; P=0.19) or of gross or microscopic infarcts separately. Findings were essentially unchanged when considering number of baseline aPLs, aPLs proximate to death, and persistence of aPLs. Associations did not differ among subjects with increased severity of vessel disease.Overall, we did not find evidence that aPLs increase the odds of pathological brain infarcts in older people.
Endothelial dysfunction in patients with chest pain and normal coronary arteries.
Authors: A A Quyyumi, R O Cannon, J A Panza, J G Diodati, S E Epstein
Journal: Circulation (1992)

A subgroup of patients with chest pain and angiographically normal epicardial coronary arteries have reduced dilator response to metabolic or pharmacological stimuli, but the mechanisms responsible for this reduced dilator response are unknown. In this study, we have investigated whether microvascular endothelial dysfunction is a cause of the observed reduced vasodilator reserve.The functional response of the microvasculature was studied with rapid atrial pacing at 150 beats per minute. Fifty-one patients, 20 hypertensive and 31 normotensive, with chest pain and normal epicardial coronary arteries (< 10% stenosis) were studied. Endothelial function was tested with incremental infusions of acetylcholine to achieve estimated intracoronary concentrations ranging from 10(-7) M to 10(-5) M. Endothelium-independent smooth muscle vasomotion was measured using intracoronary sodium nitroprusside. Endothelial dysfunction of epicardial coronary arteries, demonstrated as severe (> 50%) constriction with < 10(-5) M acetylcholine concentration, was evident in five patients (10%). In the remaining 46 patients, coronary blood flow increased with acetylcholine (mean, 78 +/- 43%) and atrial pacing (mean, 51 +/- 37%), and coronary vascular resistance decreased by 35 +/- 16% and 29 +/- 14%, respectively, but the responses were heterogeneous. There was a correlation between the coronary resistance change with acetylcholine and the change with atrial pacing: r = 0.68, p < 0.001 in these 46 patients. Thus, patients with depressed dilation with atrial pacing had reduced endothelium-dependent dilation with acetylcholine, and vice versa. However, the microvascular dilation caused by sodium nitroprusside was not significantly different between patients with and those without reduced dilation with atrial pacing, indicating that the vasodilator defect was not caused by smooth muscle dysfunction. There were no differences in the vasodilator responses with atrial pacing, acetylcholine, or nitroprusside between normotensive and hypertensive patients. Multivariate regression analysis was performed to determine whether age, sex, serum cholesterol level, hypertension, presence of mild epicardial vessel atherosclerosis, resting left ventricular function, change in left ventricular ejection fraction with exercise, vasodilation with acetylcholine, and vasodilation with sodium nitroprusside were independently related to the vasodilator response to atrial pacing. Only the change in coronary vascular resistance with acetylcholine was independently correlated with the change in resistance with atrial pacing: R2 = 0.46, p < 0.0001.Patients with chest pain, normal epicardial coronary arteries, and reduced vasodilation in response to atrial pacing appear to have associated endothelial dysfunction of the coronary microvasculature. Thus, microvascular endothelial dysfunction may contribute to the reduced vasodilator reserve with atrial pacing and anginal chest pain in these patients.
Use of proton pump inhibitors may cause squamous epithelial masking of intramucosal carcinoma in Barrett's esophagus
Authors: K. Tanaka, H. Toyoda, S. Kadowaki, Y. Hamada, R. Kosaka, M. Yamanaka, I. Imoto
Journal: Endoscopy (2007)

We present here a rare case of intramucosal carcinoma arising in Barrett’s esophagus, but masked with squamous epithelium because of administration of a proton pump inhibitor.
Treatment of Mushroom Poisoning
Authors: Marshall Tate
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The review of mushroom poisoning by Hanrahan and Gordon<sup>1</sup>and the letter by Olson et al<sup>2</sup>point out the lack of a treatment of choice for<i>Amanita</i>poisoning and the need for further study in this area. Because the medical literature is replete with erroneous myths and misinformation concerning mushroom poisoning, we wish to point out a needed correction. The standard dosage of intravenous thioctic acid is 50 to 150 mg every six hours<sup>3</sup>and not 300 mg/kg/day as published in Hanrahan and Gordon's article. While mushroom poisoning may seem to some an obscure rarity common only among mycophagists, it is a growing problem. In 1984, the Oregon Poison Control and Drug Information Center answered more than 600 calls concerning mushroom poisonings.
The microbiome revolution
Authors: Martin J. Blaser
Journal: Journal of Clinical Investigation (2014)

The collection of bacteria, viruses, and fungi that live in and on the human body, collectively known as the microbiome, has recently emerged as an important factor in human physiology and disease. The gut in particular is a biological niche that is home to a diverse array of microbes that influence nearly all aspects of human biology through their interactions with their host; new technologies are beginning to reveal important aspects of host-microbe interactions. Articles in this Review series address how perturbations of the microbiota, such as through antibiotic use, influence its overall structure and function; how our microbiome influences the impact of infectious agents, such as C. difficile; how our microbiome mediates metabolism of xenobiotics; how the microbiota contribute to immunity as well as to metabolic and inflammatory diseases; and the role of commensal microbes in oncogenesis.
TCTAP A-163 Impact of Percutaneous Coronary Intervention on 12-month Chronic Total Occlusion Outcomes in Patients with Limited Coronary Collateral Flow
Authors: Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Yoonjee Park, Akkala Raghavender Goud, Hu Li, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
THE VIRUS OF INFECTIOUS FELINE AGRANULOCYTOSIS
Authors: J. T. Syverton, J. S. Lawrence, R. J. Ackart, W. S. Adams, D. M. Ervin, A. L. Haskins, R. H. Saunders, M. B. Stringfellow, R. M. Wetrich
Journal: The Journal of Experimental Medicine (1943)

Thirty-two strains of an infectious filterable agent, with properties that establish it as a virus, have been isolated from a malady of cats. This disease can be readily recognized and differentiated from other feline diseases by blood studies, which make apparent the characteristic profound leucopenia and marked relative lymphocytosis in the absence of thrombopenia and appreciable anemia. (Because the cytological pictures of the bone marrow and blood are essentially similar to those which characterize human agranulocytosis, we have named the disease under study "infectious feline agranulocytosis.") The cytological reaction to the presence of the virus is further characterized by proliferation of the reticuloendothelial cells of the lymph nodes and spleen, and by the formation of intranuclear inclusion bodies in the cells of the gastro-intestinal mucosa, lymph nodes, and bronchial mucosa. The etiological agent, the virus of infectious feline agranulocytosis, is pathogenic for cats when given by the oral, intragastric, cutaneous, subcutaneous, intraperitoneal, intravenous, and intranasal routes; it can be recovered at the height of the disease from the blood, spleen, liver, lung, intestinal mucosa, nasal secretions, nasal mucosa and turbinates, feces, and urine. The virus appears to be limited in its pathogenicity to the feline species. We found that a variety of animals, as represented by albino Swiss mice, guinea pigs, domestic rabbits, and ground squirrels (Citellus richardsonii Sabine), failed entirely to react to the injection of massive doses of virus. Repeated attempts at infection of these animals regularly failed when the intranasal, intraperitoneal, subcutaneous, and intramuscular routes of inoculation were employed for single doses. The same was true when from four to six transfers in "blind" serial tissue passages were made. Moreover, attempts to propagate the virus on the chorio-allantoic membrane of the developing chick were unsuccessful. The significance of the facts is discussed in the paper that follows.
US Navy Tissue Bank
Authors: Richard B. Gresham, Vernon P. Perry, Thomas E. Wheeler
Journal: JAMA (1963)

Tissue banking, as currently practiced by the Navy, is primarily based upon the clinical demand for, and potential usefulness of, nonviable homografts. These grafts are obtained from recently deceased donors and processed for storage at room temperature. Eleven years of research on and clinical evaluation of over 4,000 patients have shown this concept to be practical and extremely useful to a military community where trauma demands transplantation surgery. As advances are made in overcoming the adverse reactions of homotransplantation, it becomes apparent that storage of viable tissues will be necessary for the support of modern medicine. Experimental work with bone marrow, certain endocrine tissues, and organ sections indicates that, by utilization of various nutrient media or freezing techniques, viable storage of functional tissue will become an integral part of the tissue bank of the near future.
Coronary arteriography: complications and indications
Authors: B. D. McCallister
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic resection of sporadic duodenal adenomas: an efficient technique with a substantial risk of delayed bleeding
Authors: V. Lépilliez, M. Chemaly, T. Ponchon, B. Napoleon, J. Saurin
Journal: Endoscopy (2008)

Data on endoscopic resection of sporadic duodenal adenoma (SDA) are sparse; we present our results concerning safety and efficacy in a retrospective analysis of saline-assisted endoscopic resection of SDA.The cases of all patients who underwent endoscopic resection for SDA between May 1998 and May 2006 were analyzed. Endoscopic resection was carried out using standard injection and cut methods. In some patients hemoclips and argon plasma coagulation were used, either for prophylaxis or for the treatment of procedure-related bleeding.Thirty-six patients with a total of 37 lesions (mean size 19 mm, range 4 - 50 mm) were analyzed. Lesions larger than 20 mm were more frequently resected piecemeal ( P = 0.022). Intraprocedural bleeding occurred in 14 % of cases, without any significant association with lesion size or the resection technique. One fatal perforation occurred. Macroscopically complete resection was achieved in 97 % of cases, as confirmed by at least one negative control endoscopy with biopsies after a mean follow-up of 15 months. Although clipping and argon plasma coagulation were not applied in any systematic way, it was noticeable that in the 20 cases in which they were used for hemostasis or prevention, no delayed bleeding was observed after the procedures. In contrast, bleeding occurred in 22 % of the 23 procedures performed without these additional techniques.Endoscopic resection is an efficient and acceptably safe technique for treating SDA. Further studies need to assess whether systematic bleeding prophylaxis will reduce the incidence of delayed hemorrhage after endoscopic resection.
Advance Medical Planning
Authors: Muriel R. Gillick
Journal: Annals of Internal Medicine (1996)

Letters1 June 1996Advance Medical PlanningMuriel R. Gillick, MDMuriel R. Gillick, MDHarvard Medical School, Boston, MA 02131Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-11-199606010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Lipkin and Potter make useful suggestions for facilitating advance planning for possible patient incompetence. Dr. Lipkin emphasizes the importance of designating a proxy and suggests an informal method of doing so; Dr. Potter suggests that proxies may perform their surrogate function better if they have access to audiotaped conversations in which patient preferences were being discussed. My major argument, however, is that current approaches to advance planning are too restrictive because they center exclusively on discussions of life-sustaining treatment in the event of incompetence. Although this form of planning is important, I suggest that having previously discussed ... Author, Article, and Disclosure InformationAuthors: Muriel R. Gillick, MDAffiliations: Harvard Medical School, Boston, MA 02131 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1996Volume 124, Issue 11Page: 1017KeywordsDecision making ePublished: 15 August 2000 Issue Published: 1 June 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Compound Hypertonic Salt in the Treatment of Septic Wounds
Authors: C. J. Cellan-Jones
Journal: BMJ (1940)

TE BRITISHAL which at post-mortem examination the signs of dysentery are found and Sonne's bacillus is isolated from the intestine.Individual susceptibility rather than virulence of organism is the most probable explanation.Clinically the diagnosis has to be made from other acute infections, especially cerebrospinal fever, and poisonings; and, in infants, also from the convulsions of the tetany of rickets.Treatment can hardly be other-than sympto- matic.Summary Two cases are reported of children, aged 20 months and 4 years.who died of toxaemia due to Sonne dysentery in under twenty-four hours; and the few similar cases in the literature are reviewed.It is a pleasure to acknowledge my indebtedness to the assis- tant deputy coroner of the County Palatine of Lancaster, Mr. A. L. Ashton.for permission to record the post-mortem findings in the two cases, and to Dr. A. E. Ravner and