Treatment of Refractory Erdheim–Chester Disease with Double Autologous Hematopoietic Stem-Cell Transplantation
Authors: Nicolas Boissel, Bertrand Wechsler, Véronique Leblond
Journal: Annals of Internal Medicine (2001)

Letters6 November 2001Treatment of Refractory Erdheim–Chester Disease with Double Autologous Hematopoietic Stem-Cell TransplantationNicolas Boissel, MD, Bertrand Wechsler, MD, and Véronique Leblond, MDNicolas Boissel, MDGroupe Hospitalier Pitié-Salpêtrière; 75013 Paris, France (Boissel, Wechsler, Leblond), Bertrand Wechsler, MDGroupe Hospitalier Pitié-Salpêtrière; 75013 Paris, France (Boissel, Wechsler, Leblond), and Véronique Leblond, MDGroupe Hospitalier Pitié-Salpêtrière; 75013 Paris, France (Boissel, Wechsler, Leblond)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-9-200111060-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Erdheim–Chester disease is a non-Langerhans form of histiocytosis with a grim prognosis, especially in cases of extraosseous involvement. Several treatments similar to those used in Langerhans cell histiocytosis have been tried, but with little effect (1, 2).An 18-year-old man presented with exophthalmos and bone pain. Exophthalmometry values were 32/28 mm for the right and left eyes, respectively (Figure). Proptosis and deterioration of visual acuity (20/200 and 20/25) were noted. Radiography showed bilateral tibial osteosclerosis. Technetium-99 bone scanning showed several sites of increased labeling. Cerebral magnetic resonance imaging disclosed a voluminous facial mass that involved both orbits ...References1. Veyssier-Belot C, Cacoub P, Caparros-Lefebvre D, Wechsler J, Brun B, Remy M, et al . Erdheim-Chester disease. Clinical and radiologic characteristics of 59 cases. Medicine (Baltimore). 1996;75:157-69. [PMID: 0008965684] CrossrefMedlineGoogle Scholar2. Miller RL, Sheeler LR, Bauer TW, Bukowski RM. Erdheim-Chester disease. Case report and review of the literature. Am J Med. 1986;80:1230-6. [PMID: 0003728520] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Groupe Hospitalier Pitié-Salpêtrière; 75013 Paris, France (Boissel, Wechsler, Leblond) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTherapy of 3 patients with Erdhiem-Chester disease with cladribin or cladribin in combination with cyclophosphamide. Case report and review of the therapyErdheim-Chester disease: a comprehensive review from the ophthalmologic perspectiveErdheim–Chester diseaseErdheim–Chester disease. 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Rywlin Slide Seminars 6 November 2001Volume 135, Issue 9Page: 844-845KeywordsBloodBoneCellsMagnetic resonance imagingOsteocalcinProteinsRenal diseasesSteroidsTransplantationVisual acuity ePublished: 6 November 2001 Issue Published: 6 November 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...