tbuckley/cabot-search huggingface dataset:
Prevalence of Plasma Lipoprotein Abnormalities in a Free-Living Population of the Central Valley, California
Authors: PETER D. S. WOOD, MICHAEL P. STERN, ABRAHAM SILVERS, GERALD M. REAVEN, JOBST VON DER GROEBEN
Journal: Circulation (1972)

In an epidemiologic study of 1,118 free-living volunteers, aged 25 to 79 (552 male, 566 female) drawn from eight counties of the Central Valley, California, the following determinations were included: a medical history, blood pressure, resting electrocardiogram, plasma total cholesterol and glycerides (following a light, fat-free breakfast), and (when lipids were considered to be elevated) plasma lipoproteins determined by electrophoresis. A subgroup of the entire study population (494 male, 503 female) free of overt diabetes and electrocardiographic abnormalities, and with diastolic blood pressure not above 100 mm Hg, that was considered to be clinically "normal," forms the basis of this report. Significant sex differences for mean levels of total cholesterol were absent or of small magnitude at all age decades up to and including the seventh. In contrast, glyceride levels for men were significantly higher than for women aged 25-59, and differences were substantial. Beyond the seventh decade, females had higher mean levels of both plasma total cholesterol and glycerides. The type IV lipoprotein pattern was the most common abnormality (8.6%) within the entire normal population and was 2.7 times as common in men (13%) as in women (4.8%). Type II pattern was less common overall (3.7%) and was more frequent in women than in men. Types III (0.2 to 0.4%) and V (0.2%) were both very uncommon, and type I was not encountered. Results were similar when the entire population (normal and abnormal) was considered. These findings suggest that sex differences in plasma total-cholesterol level cannot account for the known male preponderance in coronary heart disease within the population studied. Prolonged elevation of plasma glycerides (usually expressed as the type IV pattern) in males during the years when atherogenesis is occurring might account for the sex difference.
Goya's Lazarillo de Tormes
Authors: Thomas E. Cone
Journal: JAMA (1967)

To the Editor:—  I should like to differ with the interpretation of the Goya painting called El Garrotillo on the front cover of JAMA for Oct 31, 1966.  The statement that Goya in this picture portrays a physician examining the throat of a child is certainly the usual one. Actually, this painting illustrates a scene from the 16th-century picaresque novel Lazarillo de Tormes . Nigel Glendinning, writing in The Listener for Feb 20, 1964, states that the unpleasant-looking man is not a doctor at all, but Lazarillo's first master, the blind beggar. The evidence for this interpretation became apparent when we learned that Goya's painting illustrated a scene from the particular work of fiction mentioned above. With this knowledge all the strange details of the painting fall logically into place. The man's long nose is required by the story and is not an arbitrary contribution of the artist, since it is
Pregnancy and H1N1 Flu
Authors: Bridget M. Kuehn
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
502. Advances in the Application of Combinatorial Technology for the Optimization of Adeno-Associated Virus (AAV) Vectors
Authors: Luca Perabo, Jan Endell, Stephan Maersch, Michael Hallek, Hildegard Buening
Journal: Molecular Therapy (2006)

In vitro evolution protocols have been successfully applied to screen combinatorial AAV libraries in order to obtain mutants that escape neutralization by human sera (Perabo et al. JGM 2006; Maheshri et al. Nat Biotechnol 2006). We have further optimized panning protocols by monitoring selection rounds with Real Time PCR to follow the evolution of the viral pools after each selection round. Application of this technology to new screening experiments allowed in shorter times and at reduced costs the identification of novel capsid variants with higher transduction efficiency and improved ability to circumvent antibody neutralization at the same time. Packaging ability was unaffected by the introduced mutations. Beside providing proof of principle for the advantages of this monitoring procedure, these new variants enrich the pool of alternative vectors that can be employed for the treatment of patients with preexisting immunity to AAV-2 and further extend our knowledge of capsid biology. Our results contribute to the development of combinatorial technology for the engineering of viral particles. This emerging approach is gathering interest as alternative to rational design, overcoming the limit posed by our incomplete understanding of the infectious process, and at the same time offering a powerful tool to dissect viral biology by reverse genetics (see also abstract by Goldnau et al).
Plasminogen activator inhibitor 1 (PAI-1) levels in patients with chronic venous leg ulceration
Authors: S.H. Ibbotson, A.M. Layton, J.A. Davies, M.J.D. Goodfield
Journal: British Journal of Dermatology (1994)

Journal Article Plasminogen activator inhibitor 1 (PAI‐1) levels in patients with chronic venous leg ulceration Get access S.H. Ibbotson, S.H. Ibbotson The University Department of Dermatology, The Royal Victoria Infirmary, Newcastle upon Tyne, U. K. Search for other works by this author on: Oxford Academic Google Scholar A.M. Layton, A.M. Layton Department of Dermatology, The Leeds United Trust Hospital, Leeds, U.K Search for other works by this author on: Oxford Academic Google Scholar J.A. Davies, J.A. Davies Academic Unit of Medicine, The Leeds United Trust Hospital, Leeds, U.K Search for other works by this author on: Oxford Academic Google Scholar M.J.D. Goodfield M.J.D. Goodfield Department of Dermatology, The Leeds United Trust Hospital, Leeds, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 131, Issue 5, 1 November 1994, Page 738, https://doi.org/10.1111/j.1365-2133.1994.tb04998.x Published: 01 November 1994
Electrolyte Solution in Surgical Patients Refusing Transfusion
Authors: Seymour Gollub
Journal: JAMA (1971)

Major blood loss in 13 surgical patients was treated by infusion of crystalloid solution alone, supplemented by colloid plasma expander when necessary. Neither whole blood nor any of its components or fractions was employed at any time. For losses of 21% to 66% of blood volume, Ringer's solution, administered in three to five times the volume of blood loss, produced physiologically significant intravascular fluid increments equalling one fifth to three fifths of the shed blood. Colloid solutions were required to sustain blood volumes or blood pressure for patients with blood losses in excess of 1,200 ml, otherwise clinically significant edema was manifested. One week after surgery, blood volumes averaged 90% of original values. The death rate was three thirteenths. The average hospital stay was prolonged 3.4 days.
Relationships of Polychlorinated Biphenyls and Dichlorodiphenyldichloroethylene ( <i>p,p’</i> -DDE) with Testosterone Levels in Adolescent Males
Authors: Lawrence M. Schell, Mia V. Gallo, Glenn D. Deane, Kyrie R. Nelder, Anthony P. DeCaprio, Agnes Jacobs
Journal: Environmental Health Perspectives (2013)

Background: Concern persists over endocrine-disrupting effects of persistent organic pollutants (POPs) on human growth and sexual maturation. Potential effects of toxicant exposures on testosterone levels during puberty are not well characterized.Objectives: In this study we evaluated the relationship between toxicants [polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (p,p´-DDE), hexachlorobenzene (HCB), and lead] and testosterone levels among 127 Akwesasne Mohawk males 10 to < 17 years of age with documented toxicant exposures.Methods: Data were collected between February 1996 and January 2000. Fasting blood specimens were collected before breakfast by trained Akwesasne Mohawk staff. Multivariable regression models were used to estimates associations between toxicants and serum testosterone, adjusted for other toxicants, Tanner stage, and potential confounders.Results: The sum of 16 PCB congeners (Σ16PCBs) that were detected in ≥ 50% of the population was significantly and negatively associated with serum testosterone levels, such that a 10% change in exposure was associated with a 5.6% decrease in testosterone (95% CI: –10.8, –0.5%). Of the 16 congeners, the more persistent ones (Σ8PerPCBs) were related to testosterone, whereas the less persistent ones, possibly reflecting more recent exposure, were not. When PCB congeners were subgrouped, the association was significant for the sum of eight more persistent PCBs (5.7% decrease; 95% CI: –11, –0.4%), and stronger than the sum of six less persistent congeners (3.1% decrease; 95% CI: –7.2, 0.9%). p,p´-DDE was positively but not significantly associated with serum testosterone (5.2% increase with a 10% increase in exposure; 95% CI: –0.5, 10.9%). Neither lead nor HCB was significantly associated with testosterone levels.Conclusions: Exposure to PCBs, particularly the more highly persistent congeners, may negatively influence testosterone levels among adolescent males. The positive relationship between p,p´-DDE and testosterone indicates that not all POPs act similarly.Citation: Schell LM, Gallo MV, Deane GD, Nelder KR, DeCaprio AP, Jacobs A; Akwesasne Task Force on the Environment. 2014. Relationships of polychlorinated biphenyls and dichlorodiphenyldichloroethylene (p,p´-DDE) with testosterone levels in adolescent males. Environ Health Perspect 122:304–309; http://dx.doi.org/10.1289/ehp.1205984
Crohn's disease in the city of Derby, 1951-85.
Authors: I W Fellows, J G Freeman, G K Holmes
Journal: Gut (1990)

An epidemiological survey of Crohn's disease in the city of Derby showed that the incidence of the condition increased from 0.7/10(5) per year between 1951 and 1955 to 6.67/10(5) per year between 1981 and 1985 but seemed to reach a plateau between 1976 and 1985. Large bowel Crohn's disease was more common in patients presenting aged 60-79 years than in those aged 20-39 years. The increase in incidence was not solely due to the detection of milder disease. There was no evidence that the Asian (Indian subcontinent) population of Derby was resistant to the development of Crohn's disease.
Fifth Report to the President and Congress on the Status of Health Personnel in the United States, March 1986
Authors: Peter A. Weil
Journal: JAMA (1987)

Those of us who have been in the health care industry for some time know that in a span of less than two decades, we have gone from an estimated profound shortage of physicians to an estimate of tremendous oversupply. Contained in this approximately 500-page document is an enormous wealth of data—mostly of 1984 vintage—on physicians, physician assistants, nurses, dentists, optometrists, podiatrists, pharmacists, veterinarians, public health personnel, and allied health professionals. In separate chapters, each profession is described using current numbers, demographics, educational structure, and enrollment trends. Also, each chapter considers the key issue confronting the profession at this point in its evolution. Finally, unresolved issues and important newly funded research are documented, and, in the case of nursing and public health, a brief recommendation to Congress is appended. The bottom-line projection for 1990 and 2000 for almost all personnel is a rough balance between supply and requirements. Using various
Disturbance of cell-mediated immunity in patients with carcinoma of colon and rectum
Authors: O. N. Manousos, J. Economidou, Ch. Pathouli, G. Merikas
Journal: Gut (1973)

The cellular immune mechanisms of patients with adenocarcinoma of colon or rectum were evaluated by studying the lymphocyte response to PHA stimulation. Our results indicate that the serum of cancer patients causes a decreased blastic transformation and H(3) thymidine uptake of the lymphocytes of patients as well as of normal controls. A defect of the lymphocytes unrelated to serum factors was also present in some cancer patients. However, no relationship was found between the degree of transformation and the presence of metastases in the lymph nodes.
Naproxen and Pneumonitis
Authors: Aldo Vincent Londino
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The relationship between the use of drugs and pulmonary disease is being recognized with greater frequency. Approximately 5% of patients admitted to hospitals are there because of adverse reactions to drugs.<sup>1</sup>With reference to the article "Pulmonary Infiltrates Associated With Naproxen,"<sup>2</sup>the following case is reported in support of a hypersensitivity pneumonitis due to naproxen sodium. <h3>Report of a Case.—</h3> A 48-year-old woman had seropositive rheumatoid arthritis and a biopsy-proved diagnosis of "rheumatoid lung" seven years ago. She had right and left upper lobe pulmonary infiltrates, with prompt and complete resolution following therapy with prednisone, 60 mg daily. Three years later she had pulmonary infiltrates while receiving naproxen sodium, 250 mg twice a day; a sputum examination at that time revealed clumps of eosinophils with a peripheral eosinophil count of 1,104/cu mm. Again, there was complete resolution following prednisone therapy. In February 1984, she was
Antioxidant Supplements and Cardiovascular Disease in Men
Authors: Sebastian J. Padayatty
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Achalasia: Botulinum Toxin Injection vs. Pneumatic Balloon Dilation. A Prospective Study with Long-Term Follow-Up
Authors: H. D. Allescher, M. Storr, M. Seige, R. Gonzales-Donoso, R. Ott, P. Born, E. Frimberger, N. Weigert, A. Stier, M. Kurjak, T. Rösch, M. Classen
Journal: Endoscopy (2001)

Corrected by: Treatment of Achalasia: Botulinum Toxin Injection vs. Pneumatic Balloon Dilation. A Prospective Study with Long-Term Follow-UpEndoscopy 2004; 36(02): 1-1DOI: 10.1055/s-2004-814189
Effects of weight bearing and non-weight bearing exercises on bone properties using calcaneal quantitative ultrasound
Authors: P S Yung, Y M Lai, P Y Tung, H T Tsui, C K Wong, V W Y Hung, L Qin
Journal: British Journal of Sports Medicine (2005)

Objective: This study was designed to investigate bone properties using heel quantitative ultrasound (QUS) in young adults participating in various sports. Methods: A cross sectional study was performed on Chinese male students (n = 55), aged 18–22 years. Subjects with previous fractures or suffering from any diseases known to affect bone metabolism or taking any medication with such an effect, were not included. The subjects were categorised according to their main sporting activities, including soccer (n = 15) (a high impact, weight bearing exercise), dancing (n = 10) (a low impact, weight bearing exercise), and swimming (n = 15) (non-weight bearing exercise). A sedentary group acted as controls (n = 15). A reproducibility study of the velocity of sound (VOS) and the broadband ultrasound attenuation (BUA) measurement was performed and analysed using the intraclass correlation coefficient (ICC). Results: There was good intra-investigator and inter-investigator agreement (ICC⩾0.8; p&lt;0.05) in the measurement of BUA and VOS. No significant differences in BUA and VOS (p&gt;0.05) were found between the dominant and non-dominant heel. Soccer players (137±4.3 dB/MHz; 1575±56 m/s; 544.1±48.4) and dancers (134.6±3.7 dB/MHz; 1538±46 m/s; 503.0±37.0) had significantly higher BUA, VOS, and stiffness index (SI) scores (p&lt;0.05), respectively, than swimmers (124.1±5.1 dB/MHz; 1495±42 m/s; 423.3±46.9) and the sedentary control group (119.9±6.1 dB/MHz; 1452±41 m/s; 369.9±46.4). A trend of a significant linear increase with the weight bearing and high impact exercise was revealed in all QUS parameters (p&lt;0.05). Conclusion: This cross sectional study indicated that regular participation in weight bearing exercise in young people might be beneficial for accruing peak bone mass and optimising bone structure.
Tc-99m MIBI SPECT Is Useful for Noninvasively Predicting the Presence of MDR1 Gene–Encoded P-glycoprotein in Patients With Hepatocellular Carcinoma
Authors: YOUNG SOO KIM, SUNG WON CHO, KWANG JAE LEE, KI BAIK HAHM, HEE JUNG WANG, HYUNHEE YIM, YOUN MI JIN, CHAN HEE PARK
Journal: Clinical Nuclear Medicine (1999)

Resistance to chemotherapeutic drugs continues to be one of the major unsolved problems in the treatment of cancer. Multidrug resistance is defined as the ability of cells exposed to a single drug to develop resistance to a broad range of structurally and functionally unrelated drugs as a result of enhanced outward transport of drugs mediated by P-glycoprotein that is encoded by multidrug resistance genes. Recent evidence has shown that Tc-99m MIBI is a suitable transport substrate for P-glycoprotein. A potential advantage of Tc-99m MIBI SPECT is its superiority to diagnose noninvasively the presence of P-glycoprotein overexpression in vivo. In this study, the authors determined the association of enhanced MIBI efflux in Tc-99m MIBI SPECT with overexpression of P-glycoprotein in hepatocellular carcinoma.Thirty-five patients with hepatocellular carcinoma were enrolled in the study. Tc-99m MIBI SPECT was performed 10 minutes after intravenous injection of 20 mCi Tc-99m MIBI. All patients had liver biopsy or surgery within 1 week of MIBI imaging. Immunohistochemical study of the biopsy or resected hepatocellular carcinoma specimens was performed using the avidin-biotin-peroxidase technique with monoclonal antibody JSB-1 directed against P-glycoprotein.On Tc-99m MIBI SPECT, 30 of 35 (85.7%) patients with hepatocellular carcinoma had no Tc-99m MIBI uptake in tumor lesions, whereas five patients with hepatocellular carcinoma had Tc-99m MIBI uptake in tumor lesions. P-glycoprotein expression was observed in tumor tissues of all the patients without Tc-99m MIBI uptake, whereas among the five patients with Tc-99m MIBI uptake, no P-glycoprotein expression was seen in tumor lesions (P < 0.015).Tc-99m MIBI SPECT is useful for noninvasively predicting the presence of MDR1 gene-encoded P-glycoprotein in patients with hepatocellular carcinoma.
Rash and Infectious Mononucleosis
Authors: YAAKOV NAPARSTEK
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 August 1982Rash and Infectious MononucleosisYAAKOV NAPARSTEK, M.D., MICHA LEVY, M.D.YAAKOV NAPARSTEK, M.D.Search for more papers by this author, MICHA LEVY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-2-284_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the detailed analysis in Aronson and associates' report (1) of the clinical features in patients with or without heterophil antibodies, one important observation seems to be missing—the occurrence of rash. Rash was reported to appear in 16% of patients with infectious mononucleosis not receiving antibiotic therapy and in up to 95% of patients with infectious mononucleosis receiving ampicillin therapy (2), yet it is a rare feature in streptococcal sore throat unless heralding scarlet fever. The general incidence of ampicillin and penicillin rash is estimated to be 7.7% and 2.7%, respectively (3).The recognition and correct attribution...References1. ARONSON M, KOMAROFF A, PASS T, ERVIN C, and BRANCH W. Heterophil antibody in adults with sore throat: frequency and clinical presentation. Ann Intern Med. 1982;96:505-8. LinkGoogle Scholar2. PULLEN H, WRIGHT N, and MURDOCH J. Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis. Lancet. 1967;2:1176-8. CrossrefMedlineGoogle Scholar3. SHAPIRO S, SLONE D, SISKIND V, LEWIS G, and JICK H. Drug rash with ampicillin and other penicillins. Lancet. 1969;2:969-72. CrossrefMedlineGoogle Scholar4. NAZARETH I. Ampicillin and mononucleosis. Br Med J 1971;3:48. CrossrefMedlineGoogle Scholar5. . Prospective study of ampicillin rash. Br Med J. 1973;1:7-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: YAAKOV NAPARSTEK, M.D.; MICHA LEVY, M.D.Affiliations: Hadassah University Hospital Jerusalem, Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOnce-Daily Therapy for Streptococcal Pharyngitis With Amoxicillin 1 August 1982Volume 97, Issue 2Page: 284-284KeywordsAntibioticsAntibodiesHyperthermiaPenicillinPharyngitisRashesScarlet feverStreptococcal infections ePublished: 1 December 2008 Issue Published: 1 August 1982 PDF downloadLoading ...
Neonatal lupus erythematosus: Analysis of HLA class II alleles in mothers and siblings from seven Japanese families
Authors: Sachiko Miyagawa, Koji Shinohara, Tomio Fujita, Kin-ichi Kidoguchi, Takaya Fukumoto, Kazuko Hashimoto, Akira Yoshioka, Toshihiko Shirai
Journal: Journal of the American Academy of Dermatology (1997)