Granulomatous Angiitis Presenting with Polymyalgia Rheumatica and Abnormal Pituitary Function
Authors: ROBIN H. MILLER
Journal: Annals of Internal Medicine (1985)

Brief Reports1 February 1985Granulomatous Angiitis Presenting with Polymyalgia Rheumatica and Abnormal Pituitary FunctionROBIN H. MILLER, M.D., JAMES J. S. CHEN, M.D., ROBERT L NEY, M.D., PHILIP TUMULTY, M.D.ROBIN H. MILLER, M.D.Search for more papers by this author, JAMES J. S. CHEN, M.D.Search for more papers by this author, ROBERT L NEY, M.D.Search for more papers by this author, PHILIP TUMULTY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-2-210 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVarious diseases of the hypothalamus have been associated with pituitary dysfunction and hypothalamic obesity syndrome. Vasculitis is a rare cause. The patient described here first presented with symptoms compatible with polymyalgia rheumatica and later developed hypothalamic obesity syndrome and a hypothalamic mass. On pathologic evaluation, the lesion was found to be granulomatous angiitis.A 64-year-old white woman was hospitalized in December 1983 because of fatigue, weight gain, and daytime somnolence. The patient had been well until June 1982, when she developed arthralgias, fever (temperatures to 38.°C), and severe muscle tenderness with proximal muscle weakness. Laboratory studies showed an elevated sedimentation...References1. KOLODNYREBEIZCAVINESSRICHARDSON EJVE. Granulomatous angiitis of the central nervous system. Arch Neurol. 1968;19:510-24. CrossrefMedlineGoogle Scholar2. CRAVIATOFEIGIN HI. Noninfectious granulomatous angiitis with a predilection for the nervous system. Neurology. 1959;9:599-609. CrossrefMedlineGoogle Scholar3. NURICKBLACKWOODMAIR SWW. Giant-cell granulomatous angiitis of the central nervous system. Brain. 1972;95:133-42. CrossrefMedlineGoogle Scholar4. ENZMANN S. Intracranal involvement of giant-cell arteritis. Neurology. 1972;27:791-7. Google Scholar5. EVERETTAMATRUDAWOOLF GJP. Hypothalamic-hypopituitarism due to temporal arteritis. Arch Intern Med. 1979;139:474-5. CrossrefMedlineGoogle Scholar6. BRAYGALLAGHER GT. Manifestations of hypothalamic obesity in man: a comprehensive investigation of eight patients and a review of the literature. Medicine (Baltimore). 1975;54:301-30. CrossrefMedlineGoogle Scholar7. BAUER H. Endocrine and metabolic conditions related to pathology in the hypothalamus: a review. J Nerv Ment Dis. 1959;128:323-38. CrossrefMedlineGoogle Scholar8. RAJJOUBWOODOMMAYA RJA. Granulomatous angiitis of the brain: a successfully treated case. Neurology. 1977;27:588-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBIN H. MILLER, M.D.; JAMES J. S. CHEN, M.D.; ROBERT L NEY, M.D.; PHILIP TUMULTY, M.D.Affiliations: Johns Hopkins Medical Institutions Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySudden death and Wegener's granulomatosis of the pituitary: Case ReportVASCULITIS AND THE NERVOUS SYSTEMRADIOGRAPHIC FEATURES OF CENTRAL NERVOUS SYSTEM VASCULITISGRANULOMATOUS ANGIITIS OF THE NERVOUS SYSTEMAngiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis.Localized isolated angiitis of the central nervous system associated with primary intracerebral lymphomaThe endocrinologic associations of the autoimmune rheumatic diseasesReferencesGranulomatous Angiitis and the Pituitary GlandJOHN A. MALLEK, M.D., LEONARD H. CALABRESE, D.O.Polymyalgia Rheumatica: The DiagnosisHERBERT KAPLAN, M.D. 1 February 1985Volume 102, Issue 2Page: 210-211KeywordsHospital medicineLesionsMuscular dystrophiesMyalgiaObesityPolymyalgia rheumaticaResearch laboratoriesTemperatureVasculitisWeight gain ePublished: 1 December 2008 Issue Published: 1 February 1985 PDF downloadLoading ...