tbuckley/cabot-search huggingface dataset:
The groin area: the Bermuda triangle of sports medicine?
Authors: Mario Bizzini
Journal: British Journal of Sports Medicine (2010)

The Bermuda triangle, a triangular area in the Atlantic Ocean, is famously known as an area where ships, planes and people have mysteriously disappeared.

The groin, an anatomical region where diagnosis and symptoms are often confusing, may also represent a Bermuda triangle, for clinicians to disappear in vortices of suppositions and assumptions.

Patients with pain in the hip region or groin, typically individuals with a long history of pain and symptoms in this area, are not so easy to manage in clinical sports medicine and physiotherapy practices. There are many common causes of groin pain in athletes with similar signs and symptoms, highlighting the importance, and at the same time the difficulty, of the differential diagnosis.1

When treating patients, clinicians often rely on specific knowledge, experience and empirical evidence in clinical-decision-making. However, according to Sackett's definition,2 the latest scientific rehabilitation evidence should also be considered. In sports physiotherapy, leading journals and international conferences may help a clinician to update knowledge and skills. Additionally, consulting evidence databases is one easy way to access research evidence: …
Cosiness is not enough
Authors: P Dormer
Journal: BMJ (1994)

During the past 20 years Britain has enjoyed a substantial growth in the art in public places movement. A part of this movement specialises in improving the design and decoration of hospitals, day centres, and similar health care facilities. But the conference Introducing Arts in Healthcare* demonstrated that art in hospitals is not about good art but about people being good to one another.

Artists argue that they can bring a special knowledge to design and decoration that designers and architects lack. Sceptics say there is no evidence that artists have special skills. And it is indeed doubtful if the professional skills of artists are as deep or as flexible as that of designers or architects. The same artists are also part of a lobby urging the NHS to make it mandatory for new hospitals to spend 1% of their construction budget on art. …
Attention Network Hypoconnectivity in Adults Diagnosed as Having Attention-Deficit/Hyperactivity Disorder in Childhood
Authors: Hazel McCarthy, Norbert Skokauskas, Thomas Frodl
Journal: JAMA Psychiatry (2014)

To the Editor We thank Qi et al1 for their contribution to this important discussion about research in attention-deficit/hyperactivity disorder (ADHD). We wish to use this opportunity to respond to the letter.
Plasma and atrial propranolol after preoperative withdrawal.
Authors: A Romagnoli, A S Keats
Journal: Circulation (1975)

Of 34 patients scheduled for aortocoronary bypass operations who were withdrawn from chronic propranolol therapy between 18 and 48 hours before anesthesia and operation, propranolol was detected in the plasma of nine and in atrial tissue of five patients. Higher plasma levels were associated with higher propranolol intake and with shorter time of withdrawal. In 15 patients withdrawn preoperatively from propranolol the heart rate and blood pressure response to 3 mug isoproterenol was not significantly different from the response of similar patients who had received no propranolol. In contrast to the response of healthy subjects, most patients with coronary artery disease responded to isoproterenol with a decrease in systolic blood pressure. Plasma propranolol levels after a 0.5 mg bolus given intravenously during operation produced a peak level of 40 ng/ml in one minute and disappeared in five minutes. These studies suggest that no beta blockade persists 18 hours after acute preoperative withdrawal of propranolol in patients taking up to 300 mg per day for control of angina. In view of the reported hazards of abrupt withdrawal of propranolol before operation and the reported usefulness of propranolol in treating tachyarrhythmias during operation, we suggest that early preoperative withdrawal of propranolol may be more hazardous than its continuation before coronary bypass operations.
Goals of Glycemic Control in Frail Older Patients With Diabetes
Authors: Sei J. Lee
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bronchial Neutrophilia in Patients with Noninfectious Status Asthmaticus
Authors: CATHERINE LAMBLIN, PHILIPPE GOSSET, ISABELLE TILLIE-LEBLOND, FABIENNE SAULNIER, CHARLES-HUGO MARQUETTE, B. WALLAERT, A. B. TONNEL
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Cellular events that occur in status asthmaticus (SA) remain poorly investigated. Autopsy studies frequently emphasized about the presence of eosinophils in bronchial airway wall, whereas recent studies reported increased number of neutrophils in patients dying of sudden-onset fatal asthma. Mucus plugs occluding the bronchial lumen are almost constant features during SA. Bronchial lavage (BL) may be useful to remove mucus plugs in cases of atelectasis and/or refractory SA. We investigated the contribution of different cell types and cellular mediators (neutrophil elastase, eosinophil cationic protein [ECP], histamine, interleukin-8 [IL-8]) to the pathogenesis of SA. We studied 16 BL from eight patients undergoing mechanical ventilation (MV) for SA (time interval from onset of MV = Day 0 to Day 11), four BL from patients undergoing MV without preexisting respiratory disease (V), 11 BL from patients with stable asthma (A) and eight BL from healthy controls (C). SA exhibited higher number and percentage of neutrophils (81.5 +/- 4.5%) than V (44.3 +/- 12.2) (p < 0.05), A (6.9 +/- 2.7) and C (9.5 +/- 3.8) (p < 0.0001), and higher number of eosinophils than V, A, and C (p < 0.01). Neutrophil elastase, ECP, and IL-8 levels were dramatically increased in SA. Histamine was higher in SA than in C and V (p < 0.05). Bronchial neutrophilia was not related to concomitant bacterial infection as bacteriological cultures were positive in only three BL. Eosinophils, mast cells and histamine were higher in BL performed within the first 48 h of MV (p < 0.05) than in BL performed later on. Our results indicate that bronchial inflammation in SA differs from bronchial inflammation in mild asthma. Persistent bronchial neutrophilia is associated with increased eosinophils and mast cells in the early phase of SA. Neutrophils may result in tissue damage and participate to the shedding of the epithelium in SA.
Campbell's Urology
Authors: Alan H. Bennett
Journal: JAMA (1980)

When reviewing a major compendium such as Volume 2 of the fourth edition of<i>Campbell's Urology</i>, one first looks at any obvious deletions in the topics discussed. None are to be found! J. H. Harrison has gathered together an excellent group of contributors for this major revision of the classic textbook for urologists. The topics covered in Volume 2 are benign and malignant neoplasms, the neurogenic bladder, embryology and anomalies, pediatric urology, and a new section on the behavioral aspects of urology. The chapters on urological oncology are written by surgeons who are well recognized in the field. Newer diagnostic and therapeutic modalities are thoroughly covered. A new section on the cytopathology of the urinary tract by Tweeddale and Dee is well illustrated and emphasizes the usefulness of the cytologic examination in urology, especially in carcinoma in situ of the bladder. Although radiation therapy is discussed in each chapter, a
Effects of prediabetes and diabetes on left ventricular and coronary microvascular functions
Authors: Dogan Erdogan, Habil Yucel, Bayram Ali Uysal, Ismail Hakkı Ersoy, Atilla Icli, Salaheddin Akcay, Akif Arslan, Fatih Aksoy, Mehmet Ozaydin, M. Numan Tamer
Journal: Metabolism (2013)
A Difficult Case: Patient needs carotid artery surgery
Authors: G. Jackson
Journal: BMJ (1995)

This patient needs carotid artery surgery by an experienced vascular surgeon. He continues to develop neurological symptoms despite medical treatment and has a greater than 90% stenosis of the symptomatic left internal carotid artery. Without cardiovascular problems and if neurologically stable he has a less than 3% risk of morbidity and death. This rises to 10-15% if his neurological state continues to fluctuate at the time of carotid surgery. It follows that his management must be a joint effort.

His condition is complicated by recent unstable angina, for which …
Synthesis and secretion of an atriopeptin-like protein in rat kidney cell culture.
Authors: D Ritter, P Needleman, J E Greenwald
Journal: Journal of Clinical Investigation (1991)

The synthesis and secretion of an atriopeptin(AP)-like prohormone (AP126ir) has been demonstrated in rat neonatal renal cell cultures. AP126ir could be detected in the cellular extract and the medium from cultured kidney cells of neonatal and adult rats using an enzyme immunoassay specific for cardiac AP prohormone. On reverse-phase high-performance liquid chromatography, the AP obtained from the extract and the medium comigrated with cardiac AP prohormone. Incubation of the renal AP in the medium with thrombin resulted in the generation of a single low molecular mass peak which migrated with the cardiac carboxy-terminal 28-amino acid AP. Neonatal kidney cells pulsed with [35S]methionine secreted radiolabeled AP126ir, which was detected by immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis chromatography. Incubation of neonatal kidney cell cultures with the protein synthesis inhibitor cycloheximide resulted in a significant decrease in both the cellular and media AP. No decrease in cellular and media AP was detected when neonatal atrial cultures were treated with cycloheximide. These data demonstrate the de novo synthesis of an AP prohormone-like protein in neonatal rat kidney cultures. Furthermore, unlike the atria, kidney cells appear to secrete AP solely by constitutive means. In primary adult rat kidney cultures, most of AP126ir was detected in the cortical tubule fraction demonstrating that these cells secrete AP126ir in the adult rat kidney. We hypothesize that the renal AP may be important as an autocrine or paracrine regulator of renal function.
Tetracycline Nephropathy
Authors: Fedon Mavromatis
Journal: JAMA (1965)

Nephropathy developed in a 33-year-old woman following the ingestion of deteriorated tetracyclines, manifested by severe acidosis, massive proteinuria, renal glucosuria, aminoaciduria, hypokalemia, hypouricemia, decreased phosphorus reabsorption, Bence-Jones proteinuria, transient hyperglycemia, and a maculopapular rash. There was a complete recovery in 25 days. A renal biopsy revealed severe tubular changes. It is suggested that the glomeruli are also affected, but to a lesser degree, and participate in the creation of the massive proteinuria.
Randomized Trial of a Home Monitoring System for Early Detection of Choroidal Neovascularization Home Monitoring of the Eye (HOME) Study
Authors: Emily Y. Chew, Traci E. Clemons, Susan B. Bressler, Michael J. Elman, Ronald P. Danis, Amitha Domalpally, Jeffrey S. Heier, Judy E. Kim, Richard Garfinkel
Journal: Ophthalmology (2013)
Drug-Induced End-Stage Renal Disease
Authors: Pierre M. Ronco, Antoine Flahault
Journal: New England Journal of Medicine (1994)

Chronic tubulointerstitial nephritis and nephritis of unknown origin account for 15 to 30 percent of the cases of end-stage renal disease (ESRD) in the United States and Europe. A substantial but as yet undetermined proportion of these cases may be due to drug-induced nephrotoxicity. Evaluating the role of nephrotoxic drugs is a critical health care issue because of the opportunity to prevent ESRD. In 1953 Spuhler and Zollinger1 suggested that the prolonged ingestion of analgesic drugs could cause tubulointerstitial nephritis (so-called analgesic nephropathy), and subsequently many studies confirmed their hypothesis. As a consequence, phenacetin was withdrawn from the market. The . . .
Response to Irwin
Authors: Marion J. Franz, John P. Bantle
Journal: Diabetes Care (2002)

The American Diabetes Association nutrition principles and recommendations (1,2) do acknowledge that a number of factors influence the glycemic response to food, including the amount of carbohydrate, type of sugar, nature of the starch, cooking and food processing, particle size, food structure, and other food components (fat and natural substances that slow digestion) as well as the fasting and preprandial glucose concentrations, severity …
Propaedeutic for a Family Psychiatry
Authors: E. Harms
Journal: Psychotherapy and Psychosomatics (1965)

Research Articles| February 11 2010 Propaedeutic for a Family Psychiatry Subject Area: Psychiatry and Psychology E. Harms E. Harms New York Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1965) 13 (5): 387–396. https://doi.org/10.1159/000285798 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation E. Harms; Propaedeutic for a Family Psychiatry. Psychother Psychosom 1 May 1965; 13 (5): 387–396. https://doi.org/10.1159/000285798 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1965Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
The histogenesis of regenerative nodules in human liver cirrhosis
Authors: Wey-Ran Lin, Siew-Na Lim, Stuart A. C. McDonald, Trevor Graham, Victoria L. Wright, Claire L. Peplow, Adam Humphries, Hemant M. Kocher, Nicholas A. Wright, Amar P. Dhillon, Malcolm R. Alison
Journal: Hepatology (2009)

Here, we investigate the clonality and cells of origin of regenerative nodules in human liver cirrhosis using mitochondrial DNA (mtDNA) mutations as markers of clonal expansion. Mutated cells are identified phenotypically by deficiency in the entirely mtDNA encoded cytochrome c oxidase (CCO) enzyme by histochemical and immunohistochemical methods. Nodules were classified as either CCO-deficient or CCO-positive, and among 526 nodules from 10 cases, 18% were homogeneously CCO-deficient, whereas only 3% had a mixed phenotype. From frozen sections, hepatocytes were laser-capture microdissected from several sites within individual CCO-deficient nodules. Mutations were identified by polymerase chain reaction sequencing of the entire mtDNA genome. In all cases except for one, the nodules were monoclonal in nature, possessing up to four common mutations in all hepatocytes in a given nodule. Moreover, the identification of identical mutations in hepatic progenitor cells abutting CCO-deficient nodules proves that nodules can have their origins from such cells.These data support a novel pathway for the monoclonal derivation of human cirrhotic regenerative nodules from hepatic progenitor cells.
Implementation of a combo videolaryngoscope for intubation in critically ill patients: a before–after comparative study
Authors: Audrey De Jong, Noémie Clavieras, Matthieu Conseil, Yannael Coisel, Pierre-Henri Moury, Yvan Pouzeratte, Moussa Cisse, Fouad Belafia, Boris Jung, Gérald Chanques, Nicolas Molinari, Samir Jaber
Journal: Intensive Care Medicine (2013)
REMARKS ON THE USE AND MISUSE OF IRON REMEDIES
Authors: E. Smith
Journal: BMJ (1908)

OCT. '7, I908. one reason or another-often from pecuniary considerations -changes his residence.Thus, in the clientele of the Victoria Dispensary, it was found that no fewer than 41 per cent. of the patients had changed residence within two years, thus multiplying infected areas.The dispensary is in intimate relationship with the sanatorium for the cure of selected cases.It chooses for this purpose such patients as are likely to do well, and who require and deserve help.The dispensary also concerns itself, when necessary, with the after-care of patients dis- charged from the sanatorium.The dispensary is, further, in close touch with hospitals, municipal or other, which afford provision for advanced, incurable cases, with a view to their segregation.The erection of such isolation hospitals is urgently called for as a factar in the campaign.The Local Government Board for Scotland has concluded that the isolation of such dangerous cases is a primary duty of the local authority.The dispensary occupies itself likewise with the selec- tion of suitable employment of light, open-air nature -for consumptive patients who may not require hospital treat- ment.This is a valuable department of activity.Many families have, in my experience, been thus saved from de6titution.School children affected by tuberculosis are similarly watched over, and removed from school in their own interest and that of others, and their education supervised on physiological lines.Moreover, the dispensary has connexions with other hospitals and charitable institutions for the double purpose of giving information and advice regarding patients who may be in such institutions for whom other arrangements may be necessary, and of drafting to such institutions suitable cases from outside.The dispensary comes to fulfil an important function in case of financial distress which is often present.Families and dependants of patients are, through the agency of the dispensary, not only safeguarded in respect of their health, but, when the chief waae-earner is affected, are brought into touch with one or other charitable fund.Inquiry is directed to such points by the nurse and members of the Samaritan Committee.The dispensary, in this way, forms the connecting link between''all agencies concerned in any way with the treatment or relief of the tuberculous poor.
Long-Term Clinical Outcomes of Lyme Disease
Authors: David L. Katz
Journal: Annals of Internal Medicine (1995)

Letters15 June 1995Long-Term Clinical Outcomes of Lyme DiseaseDavid L. KatzDavid L. KatzSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-12-199506150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:An apparent inconsistency exists in the data reported by Shadick and colleagues [1] in their retrospective cohort study of Lyme disease. The abstract notes neurocognitive impairment in four patients with a history of Lyme borreliosis. In the text, the authors report that 12 cases and only 5 controls scored more than 2 standard deviations from the mean on two or more memory tests. Finally, in Table 5, these figures are reversed, suggesting more abnormal results among controls. Perhaps these data are consistent and I have misinterpreted them, but, if so, others may also have done so. I ...REFERENCE1. Shadick NA, Phillips CB, Logigian EL, Steere AC, Kaplan RF, Berardi VP, et al. The long-term clinical outcomes of Lyme disease. A population-based retrospective cohort study. Ann Intern Med. 1994; 121:560-7. Google Scholar Author, Article, and Disclosure InformationAuthors: David L. Katz PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1995Volume 122, Issue 12Page: 960-962KeywordsCohort studiesFearInfectious diseasesInformation storage and retrievalLyme diseaseMemoryPainResearch designStandard deviationStatistical data ePublished: 15 August 2000 Issue Published: 15 June 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
3D OCT Versus FFR for Jailed Side-Branch Ostial Stenoses
Authors: Jinyong Ha, Jung-Sun Kim, Gary S. Mintz, Byeong-Keuk Kim, Dong-Ho Shin, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong
Journal: JACC. Cardiovascular imaging (2014)
Changing workload in ophthalmology: some observations from routine statistics.
Authors: M J Goldacre, R M Ingram
Journal: BMJ (1983)

Children with squints and old people with cataracts account for most of the work of ophthalmologists. Recent demographic changes have led to fewer children and more elderly patients needing treatment. So far the increased workload has been met by shortening the time patients spend in hospital, but with striking variations between districts.