Thyrotoxicosis Presenting with Secretory Diarrhea
Authors: KIM S. CULP
Journal: Annals of Internal Medicine (1986)

Brief Report1 August 1986Thyrotoxicosis Presenting with Secretory DiarrheaKIM S. CULP, M.D., VERONICA K. PIZIAK, M.D., Ph.D.KIM S. CULP, M.D.Search for more papers by this author, VERONICA K. PIZIAK, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-216 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBOTH DIARRHEA and constipation have been reported in patients with thyrotoxicosis (1, 2). Although theories support disturbances in gastrointestinal motility as the basis for these symptoms, the responsible mechanisms have yet to be defined (2, 3). Steatorrhea has been reported in hyperthyroidism, and both hyperphagia and hypermotility are believed to play important roles in this form of steatorrhea (4, 5). To our knowledge, secretory diarrhea has not been reported as a gastrointestinal manifestation of thyrotoxicosis.A 47-year-old woman had severe, watery diarrhea and weakness. She had been healthy until 2 months before admission when she had the insidious onset of...References1. SCARF M. Gastrointestinal manifestations of hyperthyroidism. J Lab Clin Med. 1936;21:1253-8. Google Scholar2. SHIER J. Hypermotility of the gastrointestinal tract in hyperthyroidism. Am J Med Sci. 1933;186:73-8. CrossrefGoogle Scholar3. NEPORENTSPESIVTSEVA MV. Motor function of gastrointestinal tract before and after I131 therapy in patients with thyrotoxicosis. Fed Proc. 1963;(Suppl 22):T1177-80. Google Scholar4. MIDDLETONTHOMPSON WG. Steatorrhea in hyperthyroidism. Gut. 1968;9:725-6. MedlineGoogle Scholar5. THOMASCALDWELLGREENBERGER FJN. Steatorrhea in thyrotoxicosis: relation to hypermotility and excessive dietary fat. Ann Intern Med. 1973;78:669-75. LinkGoogle Scholar6. KREJSFORDTRAN GJ. Diarrhea. In: SLEISENGER MH, FORDTRAN JS, eds. Gastrointestinal Disease. Philadelphia: W. B. Saunders; 1983:257-80. Google Scholar7. FINK K. The effect of the thyroid on jejunal secretions in the dog. Am J Physiol. 1944;141:598-605. CrossrefGoogle Scholar8. STERLING K. Thyroid hormone action at the cell level. N Engl J Med. 1979;300:173-7. CrossrefMedlineGoogle Scholar9. GUERRANTCHENSHARP RLG. Intestinal adenyl-cyclase activity in canine cholera: correlation with fluid accumulation. J Infect Dis. 1972;125:377-81. CrossrefMedlineGoogle Scholar10. SCHWARTZKIMBERGSHEERINFIELDSAID CDHMS. Vasoactive intestinal polypeptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa. J Clin Invest. 1974;54:536-44. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KIM S. CULP, M.D.; VERONICA K. PIZIAK, M.D., Ph.D.Affiliations: Scott and White Memorial Hospital and Clinic Temple, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiarrhea Related to Non-neoplastic Endocrine DiseasesIntractable Diarrhea in Hyperthyroidism: Management with β-Adrenergic BlockadeForewordPhenolic and tyrosyl ring iodothyronine deiodination by the caco-2 human colon carcinoma cell lineSecretory Diarrhea and ThyrotoxicosisDAVID I. CHARNEY, M.D., MC, DONNA L. MERCADO, M.D., MC 1 August 1986Volume 105, Issue 2Page: 216-217KeywordsConstipationDiarrheaGastrointestinal motility disordersHospitalsHyperphagiaHyperthyroidism ePublished: 1 December 2008 Issue Published: 1 August 1986 PDF downloadLoading ...