tbuckley/cabot-search huggingface dataset:
Abstract B2: Patterns of serum biomarkers for lung cancer are different for men and women
Authors: Robert Streeper, Elzbieta Izbicka, David Campos, Armando Diaz, Sung Baek, Rhys Mussman
Journal: Clinical Cancer Research (2010)

Abstract Introduction: Lung cancer has one of the highest mortality rates among all human cancers. Higher mortality has been noted in the past in men with the history of smoking but no significant differences in mortality exist in never smoking men and women. Some gender differences to date have been linked to genes located on sex chromosomes. Methods: We quantified levels of 57 cytokines, chemokines and growth factors using multiplexed immunoassays to determine patterns of serum biomarkers in men and women with non-small cell lung cancer (NSCLC; 250 men, 116 women) and compared these with serum marker patterns in subjects with asthma (AST; 68 men, 132 women) and normal controls (NOR; 250 men, 116 women). Data were reduced using inter-pathology comparisons with statistical significance determined using the Kruskall-Wallis U test with p &amp;lt; 0.05 considered significant. Scalar sums of inter-pathology percentage differences (NSCLC vs. NOR, AST vs. NOR and NSCLC vs. AST) in marker expression were used for hierarchically ranking the markers. We selected markers based on at least one statistically significant difference was present for a given marker; those showing marginally significant differences were discarded. Results: The markers showed unique gender- and disease specific patterns. For unisex analysis of NSCLC, we identified 36 markers with the 25% change cutoff threshold and 32 markers with the 50% cutoff. For women, we found 32 markers with the 25% cutoff and 30 with the 50% cutoff. For men, 39 markers were found at the 25% cutoff and 37 at the 50% cutoff. Expression of four markers was unique for women with NSCLC compared to NOR: IL-8 and serum amyloid P (downregulated), serum amyloid A and C-reactive protein (all upregulated). Five markers were unique for men with NSCLC compared to NOR: Insulin (downregulated), matrix metalloproteinases-7 and -8, resistin and hepatocyte growth factor (all upregulated). Three markers showed opposite patterns of expression; VEGF was downregulated in women and upregulated in men with NSCLC compared to NOR. Leptin was upregulated in women and downregulated in men and MIP-1α were upregulated in men and downregulated in women with NSCLC compared to NOR. Conclusion: Our study has revealed surprisingly large qualitative and quantitative differences in biomarker expression patterns and levels in serum specimens from men and women suffering from NSCLC. The markers appear to be products of genes residing on several chromosomes and are not limited to sex chromosomes. Our findings may have implications for the diagnosis of non-small cell lung cancer, early detection of the disease through simple blood tests, characterization of disease progression and differentiation among the pathologies. It may find application in discovery and development of novel therapeutic strategies for human diseases. Citation Information: Clin Cancer Res 2010;16(7 Suppl):B2
Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia
Authors: Thomas Schmidt, Behzad Kharabi Masouleh, Sonja Loges, Sandra Cauwenberghs, Peter Fraisl, Christa Maes, Bart Jonckx, Kim De Keersmaecker, Maria Kleppe, Marc Tjwa, Thomas Schenk, Stefan Vinckier, Rita Fragoso, Maria De Mol, Karolien Beel, Sérgio Dias, Catherine Verfaillie, Richard E. Clark, Tim H. Brümmendorf, Peter Vandenberghe, Shahin Rafii, Tessa Holyoake, Andreas Hochhaus, Jan Cools, Michael Karin, Geert Carmeliet, Mieke Dewerchin, Peter Carmeliet
Journal: Cancer Cell (2011)
13-cis-Retinoic acid in the treatment of recurrent glioblastoma multiforme
Authors: Siew-Ju See, Victor A. Levin, W.-K. Alfred Yung, Kenneth R. Hess, Morris D. Groves
Journal: Neuro-Oncology (2004)

Basic science and clinical investigations have demonstrated that 13-cis-retinoic acid (cRA) has activity against malignant gliomas. To assess its effectiveness in the setting of recurrent glioblastoma multiforme (GBM), we performed a retrospective analysis of the medical records and neuroimaging results of patients with recurrent GBM who were treated with cRA. The toxicity profile of cRA, response, and effect on progression-free survival from initiation of treatment were end points of our analysis. Eighty-two of 85 patients with a median age of 51 years received at least 1 full cycle of cRA. At the initiation of cRA treatment, the median Karnofsky performance score was 80. All patients had failed conventional radiotherapy. Seven patients were chemonaïve, whereas 75 patients had received some form of chemotherapy. Radiographic partial responses, minor responses, and stable disease were seen in 4%, 8%, and 34% of patients, respectively. Two patients were not assessable. Progression-free survival and overall survival after initiation of cRA were 10.0 and 24.6 weeks, respectively. Six-month progression-free survival was 19% for the entire group. Grade 3 or 4 toxicity developed in 14 patients (16%), one of whom developed pancreatitis and died. The results of this study demonstrate only modest efficacy for cRA therapy in this cohort of heavily pretreated patients with recurrent GBM. This data supports the use of cRA in such patients, but its further evaluation in larger, prospective, controlled studies with or without other noncytotoxic and cytotoxic agents may be warranted.
Inmate Responses to Lengthy Death Row Confinement
Authors: JOHNNIE L. GALLEMORE, JAMES H. PANTON
Journal: American Journal of Psychiatry (1972)

Psychiatric interview and psychological testing were used to ascertain the effects of extended confinement on "death row" of eight men who were evaluated upon admission to prison and periodically thereafter for at least two years. Five appeared to adjust adequately over time, three to become significantly less functional. As a group they were more likely with increased confinement to utilize projection, to identify with each other and to an antisocial life-style, and to complain about health. While their ego strength was improved, their potential for adjustment in a new environment was felt to be diminished.
Liver cancer in Taiwan falls after universal hepatitis B vaccination
Authors: S. Mayor
Journal: BMJ (1997)

The incidence of hepatocellular carcinoma in Taiwanese children has halved since the introduction of universal hepatitis B vaccination.

Researchers at the National Taiwan University in Taipei found that the average annual incidence of hepatocellular carcinoma in children aged 6-14 years fell from 0.7 per 100000 between 1981 and 1986 to 0.36 between 1990 and 1994. This followed …
Reforming England's blood transfusion service
Authors: S. C Davies
Journal: BMJ (1995)

Why the changes and why the delay?

The blood transfusion service in England is changing. In precipitating change the British government has unleashed an ill informed and acrimonious debate in the media and elsewhere. Although the change itself may be necessary, the process has been poorly handled, and delays in the implementation of decisions now risk damaging an essential service.

With the dissolution of the 14 regional health authorities in England and their replacement in April this year with eight regional offices of the NHS Executive, the regional blood transfusion centres could not have been left unchanged. The government's strategy was to establish a new special health authority, the National Blood Authority, to take their place. The National Blood Authority, set up in 1993 undertook a national review of the provision, costs, and structure of services.

Such a review was long overdue. There was, and still is, wide variation in the quality of products and clinical services offered by the 14 centres. In 1987 Professor John Cash highlighted this variation,1 but the anomalous situation has drawn little public comment. This is generally attributed to the fact that consultants in transfusion …
Mesenchymal stromal cell–derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction
Authors: Moutih Rafei, Jeremy Hsieh, Simon Fortier, MengYang Li, Shala Yuan, Elena Birman, Kathy Forner, Marie-Noelle Boivin, Karen Doody, Michel Tremblay, Borhane Annabi, Jacques Galipeau
Journal: Blood (2008)
Hawaiian Islands, Climate, Leprosy, Insanity, Crime.
Authors: D. R. Brower
Journal: JAMA (1899)

(Special Correspondence.) (On Board Steamship<i>Australia</i>, en route to San Francisco.) I left Chicago on July 7, and in three days reached San Francisco, and there met Prof. N. Senn, who had just completed, with great eclat, the Lane lectures at the Cooper Medical College. President Lane of this college, with an unheard of generosity, gives $2,000 a year for a course of ten lectures, that are intended, first, for the students of the Medical College, and second, for the practitioners of the coast generally. Dr. Senn's lectures were on military and emergency surgery, and were the fourth course. The first course was given by Macewen of Glasgow, on "Cerebral Surgery," the second by Heath of London, on "Practice of Surgery in England," and the third by Clifford, on the "Heart." The course given by Dr. Senn gathered together a much greater number of practitioners than any of the others,
Pediatrics
Authors: Sara C. McIntire
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Structural Insight into HIV-1 Restriction by MxB
Authors: Jennifer L. Fribourgh, Henry C. Nguyen, Kenneth A. Matreyek, Frances Joan D. Alvarez, Brady J. Summers, Tamaria G. Dewdney, Christopher Aiken, Peijun Zhang, Alan Engelman, Yong Xiong
Journal: Cell Host & Microbe (2014)
ABC of vascular diseases. Late complications of arterial grafts.
Authors: P. Rutter, J. H. Wolfe
Journal: BMJ (1992)

Five main types of complicationMost complications associated with the insertion of vascular grafts occur * The graft blocks (ischaemia) after the patient has been discharged from hospital, and so are presented * Late disruption around the anastomosis firstly to the general practitioner.(true and false aneurysms) Saphenous nerve damage is relatively common and may result in * The graft sends off showers of thrombi paraesthesia or numbness on the lower medial thigh.Femoral nerve damage (emboli) is mnuch less common but tiore serious, with weakness of the knee flexor * The graft becomes colonised with micro-muscles.The damage is usually reversible ifit has been caused by retraction organisms (infection) of the nerve during dissection.Carbamazepine or transcutaneous nerve * An intra-abdominal graft may erode stimulation may be useful for patients with severe unrelenting symptoms, adjacent viscera (usually aortoenteric but in most people symptoms resolve rapidly and reassurance is all that is .stulas)required.
P2-205: Long term results of concurrent chemoradiotherapy with Vinorelbine and a Platinum compound followed by consolidation chemotherapy for advanced stage III Non-Small Lung cancer (NSCLC)
Authors: Petronela Rusu, Tudor E. Ciuleanu, Dana Cernea, Doris Pelau, Viola Gaal, Cristina Cebotaru, Dana Iancu, Tiberiu Guttman, Nicolae Todor, Nicolae Ghilezan
Journal: Journal of Thoracic Oncology (2007)
Independence and the Presidency
Authors: R. S. Murley
Journal: BMJ (1970)

should be mandatory, rather than exploration.Secondly, the aetiological classification suggested in this interesting article should include amoebiasis.This disease is not limited nowadays to tropical areas and it is known to mimic many intra-abdominal emergencies.'It is especially apt to cause colonic dilatation similar to pseudo-obstruction of the large bowel, and we know that exploration in these cases may be associated with high morbidity and mortality, though in cases of toxic megacolon of amoebic ori- gin a caecostomy may be life-saving.This is the only surgical procedure which I think is justified for pseudo-obstruction.If there is acute cholecystitis, then of course cholecys- tectomy or cholecystostomy are justified (Case 2), but then it is no longer pseudo- obstruction but sentinel ileus.-Iam, etc.
Asymmetrical Hypertrophic Cardiomyopathy Simulating Mitral Stenosis
Authors: RALPH SHABETAI, SIDNEY DAVIDSON
Journal: Circulation (1972)

Hypertrophic cardiomyopathy usually involves the left ventricle more severely than the right, and when asymmetrical may produce the syndrome of idiopathic subaortic stenosis. Less commonly, clinical manifestations of inflow-tract obstruction predominate and produce a syndrome that may be mistaken for mitral stenosis, principally because of an apical diastolic rumbling murmur. The probability of this diagnostic error and the risk of a consequent unnecessary operation can be reduced by appreciating the significance of the clues to left ventricular disease revealed by the electrocardiogram and the chest roentgenogram. Furthermore, proper timing of the heart sounds differentiates the protodiastolic filling sound of cardiomyopathy from the opening snap of mitral stenosis. The correct diagnosis is established following ventriculographic and hemodynamic studies.
The Post-Bell Commission Residency: Sleep vs Care
Authors: Amy Lynn Bloch
Journal: JAMA (1989)

To the Editor.—  During the months of February and March, strange things have been taking place on the medicine service of a New York teaching hospital. A trial of altered house staff rotations that meet the Bell Commission's stipulations has replaced the traditional house staff schedule. To comply with New York State Code 405 (to take effect on July 1) mandating that medical house staff must not work for more than 24 consecutive hours, must have no less than 8 nonworking hours between shifts, and must not work more than 80 hours per week, the admitting intern is expected to sign his or her cases over to the night float at 11 PM, who in turn signs off his or her cases the next morning. Participation in the trial of this new schedule is not voluntary, but after 6 months of sleep deprivation from being awake every fourth night, I
A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients
Authors: Yoshifumi Fujimoto, Hidenori Ochi, Toshiro Maekawa, Hiromi Abe, C. Nelson Hayes, Hiromitsu Kumada, Yusuke Nakamura, Kazuaki Chayama
Journal: Journal of Hepatology (2010)
Prevalence of Primary Angle Closure and Primary Angle-Closure Glaucoma in a Southwestern Rural Population of Japan
Authors: Shoichi Sawaguchi, Hiroshi Sakai, Aiko Iwase, Tetsuya Yamamoto, Haruki Abe, Goji Tomita, Atsuo Tomidokoro, Makoto Araie
Journal: Ophthalmology (2012)
Multirow Detector Computed Tomography Assessment of Intraseptal Dissection and Ventricular Pseudoaneurysm in Postinfarction Ventricular Septal Defect
Authors: Jean-François Paul, Loïc Macé, Christophe Caussin, Abdelhamid Fsihi, Xavier Berthaux, Philippe Brenot, Claude Angel
Journal: Circulation (2001)
Discovery of Prostaglandins
Authors: Kurt A. Oster
Journal: JAMA (1983)

To the Editor.—  In the MEDICAL NEWS section (1982;248:2212), a summary on prostaglandin research states that, in the early and mid-1930s, Ulf S. von Euler, MD, reported that human semen and extracts of sheep seminal vesicular glands had peculiar properties. Because of the origin of these substances, von Euler inferred that the active agents were made mainly in the prostate gland, so he named them prostaglandins.  In 1940, I had a research appointment in the Pharmacology Department of Columbia University School of Medicine, New York, under the chairmanship of Professor C. C. Lieb. At that time, I was told that Dr Lieb as well as Dr R. Kurzrok, associate professor of pharmacology, were the original discoverers of biologic properties of an extract of semen from the prostate gland 1 published as early as 1930.
Therapy for Pulmonary Embolism
Authors: Arthur A. Sasahara
Journal: JAMA (1974)

DURING the past several years, there has been a growing awareness of the thromboembolic problem as a modern paradox: that as medical progress is being made, the incidence of thromboembolism is rising. The likely reason for this is that we are confronted with an older and sicker population who are subjected to prolonged periods of bed rest and more complex operations. From statistics, when both the primary and secondary, or contributory, causes of death are considered, pulmonary embolism may well be the most common cause of death in the hospital.<sup>1</sup>On the basis of reasonable estimates that fatal pulmonary embolism occurs in five patients per 1,000 inpatients<sup>2</sup>and nonfatal pulmonary embolism in 20 patients per 1,000 inpatients,<sup>3</sup>it can be estimated that approximately 142,000 patients suffer fatal pulmonary embolism and 568,000 suffer nonfatal pulmonary embolism each year in the United States. The mortality of untreated pulmonary embolism
685.Inhibitory Effect of Ribbon-type NF-kB Decoy Oligodeoxynucleotides on Osteoclast Induction and Activity
Authors: Yasuo Kunugiza, Tetsuya Tomita, Naruya Tomita, Mariana Kiomy Osako, Takuji Kizawa, Keishi Sekiguchi, Ryuichi Morishita, Hideki Yoshikawa
Journal: Molecular Therapy (2005)

Purpose: Osteoclasts, multinucleated giant cells that resorb bone, develop from hematopietic cells of the monocyte/macrophage lineage. We examined the effect of ribbon-type NF-kB decoy oligodeoxynucleotides ODN (RDODN) on induction and activity of osteoclasts.
Rectal band ligation for treatment of extensive chronic hemorrhagic radiation proctitis
Authors: B. Mangiavillano, E. Morandi, P. Viaggi, M. Arena, E. Masci
Journal: Endoscopy (2012)

Chronic radiation proctitis is an infrequent complication of pelvic radiotherapy, occurring in 5 % – 20 % of patients [1]. Argon plasma coagulation (APC) is the preferred endoscopic therapy for treatment of chronic radiation proctitis and is considered effective and well tolerated.
Fistula Between Abdominal Aortic Aneurysm and Anomalous Renal Vein
Authors: Jere W. Lord, John Vigorita, Joseph Florio
Journal: JAMA (1964)

IN RECENT YEARS several case reports<sup>1-4</sup>of successful repair of an arteriovenous fistula between an atherosclerotic aneurysm of the abdominal aorta and the inferior vena cava have been published. In each instance the predominant clinical feature has been high-output cardiac failure. It is the purpose of this paper to record the first case of an arteriovenous fistula between an atherosclerotic abdominal aortic aneurysm and an anomalously placed retroaortic left renal vein. The predominant clinical features were quite different from those of aorto-vena caval fistula. In our patient, left flank and abdominal pain was severe and associated with a pulsating abdominal mass and continuous bruit over the left side of the abdomen and back. Resection of the aneurysm and closure of the opening in the left renal vein with preservation of its continuity and insertion of a bifurcating, crimped, knitted Dacron prosthesis led to healing of the lesion and a
Collaborations aim to develop new drugs for neglected tropical diseases
Authors: J. H. Tanne
Journal: BMJ (2009)

The Drugs for Neglected Diseases Initiative meeting in Nairobi, Kenya, on 23 June heard promising news about collaborations to develop drugs to treat neglected tropical diseases.

The meeting brought together more than 200 scientists, researchers, academics, and global health leaders from Africa and abroad to consider new treatments for diseases such as visceral leishmaniasis (kala-azar), Chagas’ disease, and sleeping sickness.

The initiative said that better treatments are needed by millions of the world’s poorest people. Current treatments are often toxic, prohibitively expensive, or difficult to administer in countries with limited resources. Drug companies have little incentive to develop treatments for neglected diseases that mainly …
Redefining quality of care
Authors: Erik K Mayer, Sanjay Purkayastha, Thanos Athanasiou, Ara W Darzi
Journal: Journal of the Royal Society of Medicine (2007)

There is increasing interest in evaluating the quality of care delivered by health care providers and its impact on the overall satisfaction of the end-user, namely the patient. Despite the political incentives that such research evokes, important questions surrounding this topic must be answered to improve the way in which care is delivered. This signals important changes in the way that patients, clinicians, scientists and administrators, evaluate outcomes of treatment.
The D-State
Authors: Ernest L. Hartmann
Journal: New England Journal of Medicine (1965)

Pharmacology and the D-StateA great many data, mostly from small informal studies, are available concerning the effect of drugs on the D-state, but as yet no definite pattern has emerged. A number of substances decrease the amount of time spent in the D-state. This is true in man for phenobarbital and several other barbiturates studied so far.20 Phenothiazines likewise tend to decrease D-time; trifluoperazine (Stelazine) has some confusing early effects54 but probably actually decreases D-time like the others.55 Alcohol has been shown to cause a decrease in D-time,56 and in fact it has been suggested that delirium tremens may . . .
Response to Letter Regarding Article, “Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy”
Authors: Raffaele Coppini, Cecilia Ferrantini, Martina Del Lungo, Francesca Stillitano, Laura Sartiani, Benedetta Tosi, Silvia Suffredini, Chiara Tesi, Corrado Poggesi, Elisabetta Cerbai, Alessandro Mugelli, Lina Yao, Peidong Fan, Luiz Belardinelli, Magdi Yacoub, Iacopo Olivotto
Journal: Circulation (2013)
Promoting research into peer review
Authors: R Smith
Journal: BMJ (1994)

<h3>Abstract</h3> COVID-19 has spread in all continents in a span of just over three months, escalating into a pandemic that poses several humanitarian as well as scientific challenges. We here investigated the geographical character of the infection and correlate it with several annual satellite and ground indexes of air quality in: China, the United States, Italy, Iran, France, Spain, Germany, and the United Kingdom. Controlling for population size, we found more viral infections in those areas afflicted by high PM 2.5 and Nitrogen Dioxide values. Higher mortality was also correlated with relatively poor air quality. In Italy, the correspondence between the Po valley pollution and SARS-CoV-2 infections and induced mortality was the starkest, originating right in the most polluted European area. Air pollution appears to be for this disease a risk factor similar to smoking. This suggests the detrimental impact climate change will have on the trajectory of future respiratory epidemics.