tbuckley/cabot-search huggingface dataset:
Hepatoprotective effect of endogenous nitric oxide during ischemia-reperfusion in the rat
Authors: Charles-Henry Cottart, Louis Do, Marie-Céline Blanc, Michel Vaubourdolle, Geneviève Descamps, Dominique Durand, François-Xavier Galen, Jean-Pierre Clot
Journal: Hepatology (1999)

The aim of this study was to evaluate the protective or deleterious effects of endogenous nitric oxide (NO) on liver cells during hepatic ischemia–reperfusion (IR) in the rat. Injury to hepatocytes and endothelial cells was evaluated by determining cytolysis–marker activity in plasma (alanine transaminase [ALT]; aspartate transaminase [AST]) and plasma hyaluronic acid (HA) concentration. Clamping the hepatic pedicle for 45 minutes caused a significant increase in plasma AST and ALT activity after 30 minutes of reperfusion, which reached a maximum (+270% and +740%, respectively) after 6 hours of reperfusion. Plasma HA concentration was significantly higher (+130%) only after 6 hours of reperfusion. Administration of a nonselective NO synthase (NOS) inhibitor, Nω–nitro–L–arginine (L–NNA; 10 mg/kg iv), 30 minutes before IR, caused marked aggravation of postischemic liver injury, as shown by plasma ALT and AST activity and HA concentration. This deleterious effect was partially prevented by the simultaneous injection of L–arginine, the endogenous NO precursor (100 mg/kg iv). Interestingly, L–arginine alone limited postischemic damage (AST, -25%; ALT, -45%; HA, -21% vs. untreated IR rats at 6 hours reperfusion). Pretreatment with the Guanosine 3′:5′–cyclic monophosphate–independent vasodilator, prazosin, partially reversed L–NNA effects, but it did not protect untreated IR animals. Pretreatment with aminoguanidine, a selective inhibitor of inducible NOS, did not aggravate hepatic IR injury. Thus, endogenous NO, probably produced by an early and transient activation of a constitutive NOS, protects both hepatocytes and endothelial cells against liver ischemia-reperfusion injury, and this effect is not entirely a result of vasorelaxation.
Guantanamo breaches right to health, says UN
Authors: John Zarocostas
Journal: BMJ (2006)

Harsh treatment in the US detention camp at Guantanamo Bay has had profound effects on the mental health of many of the detainees and constitutes a breach of their right to health, a joint report by five UN independent experts has concluded.

“The treatment and conditions include the capture and transfer of detainees to an undisclosed overseas location, sensory deprivation and other abusive treatment during transfer; detention in cages …
Hormone Therapy and Cardiovascular Risk—Reply
Authors: Jacques E. Rossouw, Ross L. Prentice, Andrea Z. LaCroix, LieLing Wu, JoAnn E. Manson, David Barad, Vanessa M. Barnabei, Marcia Ko, Karen Margolis, Marcia Stefanick
Journal: JAMA (2007)

In Reply: Dr Shapiro postulates that detection bias in women who developed vaginal bleeding after randomization to CEE + MPA may have led to an overestimate of their HRs for CHD. Several considerations argue against this interpretation.
Outcome of carbon dioxide laser therapy for persistent cutaneous viral warts
Authors: R.A. LOGAN, C.B. ZACHARY
Journal: British Journal of Dermatology (1989)

Twenty-two adults with persistent, symptomatic viral warts on the hands or feet which had failed to respond to conventional therapy were treated by carbon dioxide (CO2) laser ablation under local anaesthesia. Four patients did not return for follow-up treatment. Of the remaining 18 patients, 12 had plantar warts, the other six had warts on the hands that were mainly periungual. The median duration of the warts prior to laser treatment was 5 years. The areas treated were solitary in eight and multiple in 10 cases. After an average follow-up period of 10 months (minimum 6 months), all of the treated areas were clear of warts in 10 patients (56%), some had cleared in three, and all the treated warts had relapsed in the other five patients. Side-effects were commonly observed, especially post-operative pain, temporary loss of function of the treated part and scarring. The use of the CO2 laser may clear otherwise resistant viral warts but a significant morbidity may occur with this method of treatment.
Quantitative angiographic methods for appropriate end-point analysis, edge-effect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation
Authors: Alexandra J Lansky, George Dangas, Roxana Mehran, Kartik J Desai, Gregg W Stone, Martin B Leon, Gary S Mintz, Ron Waksman, Hongsheng Wu, Martin Fahy
Journal: Journal of the American College of Cardiology (2002)
Long Term Results of Valve Sparing Aortic Root Replacement; A Single Center Experience
Authors: Şahin Şenay, Ahmet Ümit Güllü, Aleks Değirmencioğlu, Muharrem Koçyiğit, Eyüp Murat Ökten, Cem Arıtürk, Gültekin Karakuş, Ertuğrul Zencirci, Fevzi Toraman, Hasan Karabulut, Cem Alhan
Journal: Journal of the American College of Cardiology (2013)
Damage Compounded or Damage Lessened? Disparate Impact or the Compromises of Multiculturalism?
Authors: Sarah E. Shannon
Journal: The American Journal of Bioethics (2006)

"Damage Compounded or Damage Lessened? Disparate Impact or the Compromises of Multiculturalism?." The American Journal of Bioethics, 6(5), pp. 27–28
HIV-1 Messenger RNA in Peripheral Blood Mononuclear Cells as an Early Marker of Risk for Progression to AIDS
Authors: Kalle Saksela
Journal: Annals of Internal Medicine (1995)

To establish human immunodeficiency virus type 1 (HIV-1) messenger RNA (mRNA) expression in peripheral blood mononuclear cells as a marker of risk for progression to the acquired immunodeficiency syndrome (AIDS) in a large cohort of HIV-infected persons followed for a prolonged period.Retrospective testing of cryopreserved, coded specimens.Research laboratories at the New York Blood Center and the Rockefeller University.150 homosexual men infected with HIV-1 who did not have an AIDS diagnosis at the time of testing.Multiply spliced and unspliced HIV-1 mRNAs in total peripheral blood mononuclear cell RNA were quantitated using reverse transcriptase-initiated polymerase chain reaction (PCR) and compared with other laboratory data and clinical outcome during the subsequent 8 years.Although HIV-1 mRNA expression generally correlated with immunologic status, it was associated with future disease progression independently of CD4+ cell counts or their rate of decrease at the time of sampling. The association of HIV-1 mRNA with disease progression in persons with CD4+ cell counts higher than the median (> 624 cells/mm3) was particularly noteworthy; further variation in the CD4+ cell counts within this group was not prognostically significant.The expression of HIV-1 mRNA in peripheral blood mononuclear cells is a strong independent marker for future HIV disease progression, even in persons with normal T-cell subsets.
LEAD STUDIES
Authors: Joseph C. Aub, Paul Reznikoff, Dorothea E. Smith
Journal: The Journal of Experimental Medicine (1924)

The physiological changes following the reaction of lead upon red blood cells are numerous and show the marked effects of a change in the cell surface. In experiments here reported 0.01 to 0.05 mg. of lead acting upon 5 billion red cells caused such marked variations from normal as: 1. Partial loss of the normal stickiness of red corpuscles, which is demonstrated by their falling from a clean glass surface. 2. Loss of the agglutination reaction which normally follows mixture with serum of a different isoagglutinating group. 3. Decrease in volume even in isotonic solutions. 4. Loss of normal elasticity and, therefore, reduced changes in volume upon exposure to marked variations in osmotic tension. 5. Increase in resistance to large changes in external osmotic pressure because of this inelasticity, and therefore decreased hemolysis in hypotonic salt solution (Part 1). 6. Increase in the speed of disintegration in spite of this increased resistance to external osmotic pressure. "Leaded" cells break up more readily upon standing than do normal cells, and are easily fractured by rotation or shaking (Part 1). All these phenomena seem to be associated largely with surface changes in the corpuscles. Evidence is cited that there is no chemical reaction between lead and hemoglobin. The gas exchange is identical in normal and "leaded" cells. The function of the interior of the red cells, therefore, appears to be unaffected by lead. The effects of lead upon red blood cells are thus manifested by shrinkage, inability to expand, increased brittleness, and loss of the normal consistency which makes their surface sticky. After exposure to lead, red blood corpuscles are more like hard inelastic brittle rubber balls, than like the soft, elastic, resilient cells characteristic of normal blood.
John Pearse Dymond Max Hulbert Daniel Crawford Logan Brian Mindham John Bartlett Roberts
Authors: A. Ferguson
Journal: BMJ (2001)

John was a colourful figure, with a predilection for striped blazers, white silk dinner jackets, hats, buttonholes, and club ties, of which he had a magnificent collection.His sense of humour was legendary, and this helped colleagues through many difficult situations.He was pressed into service as best man on several occasions and was a great companion at both formal and informal dinners, when he would demonstrate his knowledge of wines and good food.He was a trainer and course
Memories of Lord Moynihan. A conversation between Sir Reginald Murley and John Hosford.
Authors: J. Hosford
Journal: BMJ (1988)

While I amputated one man's thigh there lay, at one time, thirteen all beseeching to be taken next.It was strange to feel my clothes stiff with blood and my arms powerless with the exertion of using my knife."22Bell was also a talented artist and his watercolours of the wounded, now in the RAMC Historical Museum, are an evocative record of his work.Of those patients not fit enough to return to active duty most returned to England, via Ostend, over the following months.Some were not evacuated until early in 1816.3The most severely disabled soldiers were transferred to the York Hospital in Chelsea where Guthrie practised until its dissolution two years later.23
Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy
Authors: Jaakko Sarparanta, Per Harald Jonson, Christelle Golzio, Satu Sandell, Helena Luque, Mark Screen, Kristin McDonald, Jeffrey M Stajich, Ibrahim Mahjneh, Anna Vihola, Olayinka Raheem, Sini Penttilä, Sara Lehtinen, Sanna Huovinen, Johanna Palmio, Giorgio Tasca, Enzo Ricci, Peter Hackman, Michael Hauser, Nicholas Katsanis, Bjarne Udd
Journal: Nature Genetics (2012)
Peroral cholangioscopy: new approach with a balloon enteroscope
Authors: P. Muralikrishna, K. Madhu, A. Aditya, V. Srinivas, E. Veerraju
Journal: Endoscopy (2008)

Advances in endoscopic technology have expanded the horizons of interventional endoscopy [1]. Starting with rigid optical endoscopes that could access only either end of the digestive system, endoscopy evolved to enable visualization of the entire gastrointestinal tract with the development of capsule endoscopy and double-balloon enteroscopy [2]. However, the biliary-pancreatic system still remained a side track. The available biliary-pancreatic endoscopes are expensive, suboptimal, and not widely available [3] [4]. Optimal visualization of the bile duct lumen enabling direct interventions through an adequate working channel remains a dream. Working under the odds of third-world realities, we recently adapted the diagnostic double-balloon enteroscope to serve as a peroral choledochoscope, without the need for an expensive mother–baby system.
ASSOCIATION OF LARGE LIPID CORE PLAQUE DETECTED BY NEAR INFRARED SPECTROSCOPY WITH POST PERCUTANEOUS CORONARY INTERVENTION MYOCARDIAL INFARCTION
Authors: Brijeshwar Maini, Emmanouil S. Brilakis, Michael Kim, Michael J. Hendricks, Stephen T. Sum, Sean P. Madden, James E. Muller, David Rizik, Simon R. Dixon
Journal: Journal of the American College of Cardiology (2010)
Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies
Authors: Stephen Gottschalk, Oliver L. Edwards, Uluhan Sili, M. Helen Huls, Tatiana Goltsova, Alan R. Davis, Helen E. Heslop, Cliona M. Rooney
Journal: Blood (2003)
Critical role for Gab2 in transformation by BCR/ABL
Authors: Martin Sattler, M.Golam Mohi, Yuri B Pride, Laura R Quinnan, Nicole A Malouf, Klaus Podar, Franck Gesbert, Hiromi Iwasaki, Shaoguang Li, Richard A Van Etten, Haihua Gu, James D Griffin, Benjamin G Neel
Journal: Cancer Cell (2002)
Impairment Prevention in the Training Years
Authors: Daniel B. Borenstein
Journal: JAMA (1982)

The new Mental Health Program for Physicians in Training, at UCLA, offers free psychiatric evaluation and short-term psychotherapy to UCLA medical students and house officers, utilizing a large group of physician volunteers from the clinical and regular faculties. The program features complete confidentiality and an off-campus setting and provides help in a number of specialized areas. It also conducts research on stress in medical education. A basic aim is to promote a sense of community in the medical profession by demonstrating the concern of mature practitioners for their young colleagues. It also seeks to foster greater sensitivity among young physicians by educating them about the importance of their own psychological needs. The UCLA program provides a model for mental health services that are low in cost, both to medical trainees and to the training institution, at a time of severe budget shrinkage.
Fibrin Split Products in Acute Pulmonary Embolism
Authors: FRANK D. RICKMAN
Journal: Annals of Internal Medicine (1973)

The concentration of fibrin split products (FSP) was measured, by using a modification of the staphylococcal clumping test, in 46 patients who had pulmonary angiography for suspected acute pulmonary embolism and in 12 normal control subjects. The concentration was significantly higher in 19 patients with angiographically documented pulmonary embolism (mean FSP, 158 µg/ml) than in 22 patients without (mean, 8 µg/ml; P < 0.001)—in 18 of the 19 patients the concentration was > 10 µg/ml; in 19 of the 22 patients without pulmonary embolism it was 10 µg/ml or less. The levels were highest in patients with acute symptoms (<3 days) and in those with significant increases in total pulmonary resistance, as measured at cardiac catheterization. Fibrin split products concentration seems to be increased (>10 µg/ml) in most patients with acute pulmonary embolism. We had only one false-negative finding; however, the specificity of an elevation of this variable in acute pulmonary embolism needs further assessment.
Hypercapnic acidosis and dimethyl amiloride reduce reperfusion induced cell death in ischaemic ventricular myocardium
Authors: S. H Kaplan, H. Yang, D. E Gilliam, J Shen, J. J Lemasters, W. E Cascio
Journal: Cardiovascular Research (1995)

Journal Article Hypercapnic acidosis and dimethyl amiloride reduce reperfusion induced cell death in ischaemic ventricular myocardium Get access Stephanie H Kaplan, Stephanie H Kaplan aDepartment of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Hua Yang, Hua Yang aDepartment of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Deborah E Gilliam, Deborah E Gilliam aDepartment of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar J Shen, J Shen aDepartment of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar John J Lemasters, John J Lemasters bDepartment of Cell Biology The University of North Carolina School of Medicine, Chapel Hill, NC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Wayne E Cascio Wayne E Cascio * *Correspondence to Dr Cascio, at Division of Cardiology, CB#7075, Burnett-Womack Building, Chapel Hill, NC 27599-7075, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 2, February 1995, Pages 231–238, https://doi.org/10.1016/S0008-6363(96)88575-0 Published: 01 February 1995 Article history Received: 31 March 1994 Accepted: 21 November 1994 Published: 01 February 1995
785 Hepatocyte growth factor accelerates differentiation of hepatic oval cells in a 2-acetylaminofluorene/partial hepatectomy model in rat
Authors: S HASUIKE, H UTO, C NAKANISHI, K KUSUMOTO, S YAMAMOTO, T HORI, K HAYASHI, H TSUBOUCHI, Y NAGATA, A MORIUCHI
Journal: Hepatology (2003)

A series of 4-substituted 1-acyl-1,2,4-triazolidine-3,5-diones demonstrated potent activity in CF, mice when administered intraperi- toneally at 20 mg/kg/day, lowering both serum cholesterol and triglyceride levels significantly. The 4-(4-chlorophenyl)-substituted compounds demonstrated better hypolipidemic activity In rodents than 4-methoxy-, 4-nitro-, and 4-f-butylphenyl substitutions. Aryl and alkyl substitutions rather than benzoyl substitutions at position 4 demonstrated good hypocholesterolemic activity. Selected compounds were examined for the mode of action in rats in which serum cholesterol and triglyceride levels were reduced after administration of 20 mg/kg/day orally; tissue lipids were reduced after 14 days of administration, and bile and fecal lipids were increased by 44-250%. Serum lipoprotein levels were also modulated by the agents, with cholesterol levels in very low density lipoprotein and low density lipoprotein fractions being reduced by 2-57%. Cholesterol levels in the high density lipoprotein fraction were elevated by 94-341%. Activities of mouse hepatic enzymes were suppressed by the agents in a manner that suggested that the compounds interfere with de novo synthesis of lipids.
Positron emission tomography demonstrates that coronary sinus retroperfusion can restore regional myocardial perfusion and preserve metabolism
Authors: George T. O’Byrne, Christoph A. Nienaber, Akira Miyazaki, Luis Araujo, Michael C. Fishbein, Eliot Corday, Heinrich R. Schelbert
Journal: Journal of the American College of Cardiology (1991)
c-Jun NH2-Terminal Kinase 1 Is a Critical Regulator for the Development of Gastric Cancer in Mice
Authors: Wataru Shibata, Shin Maeda, Yohko Hikiba, Ayako Yanai, Kei Sakamoto, Hayato Nakagawa, Keiji Ogura, Michael Karin, Masao Omata
Journal: Cancer Research (2008)

Abstract c-Jun NH2-terminal kinase (JNK) links several cellular processes, including proliferation and survival, and is believed to be involved in carcinogenesis. However, the role of JNK in gastric tumorigenesis is unknown. Immunohistochemical analysis reveals that JNK is frequently activated in human gastric cancer tissue. We investigated whether JNK1, a major JNK isozyme, is involved in chemically induced gastric cancer development. Mice lacking JNK1 exhibited a marked decrease in gastric carcinogenesis induced by N-methyl-N-nitrosourea, relative to their wild-type counterparts. Impaired tumor development correlated with decreased tumor initiation, which is associated with the production of reactive oxygen species. We also found that lower levels of tumorigenesis were correlated with the decreased expression of cyclin D and CDK as well as decreased cell proliferation. Taken together, JNK seems to be involved in both tumor initiation and promotion and may be an attractive target for the prevention of gastric carcinogenesis. [Cancer Res 2008;68(13):5031–9]
Male Breast Cancer: A Population-Based Comparison with Female Breast Cancer.
Authors: W. Anderson, I. Jatoi, P. Rosenberg
Journal: Cancer Research (2009)

Abstract Purpose: Because of its rarity, male breast cancer is often compared to female breast cancer.Materials and Methods: To compare and contrast male and female breast cancers, we obtained case and population data from the NCI's Surveillance, Epidemiology, and End Results program for breast cancers diagnosed from 1973 through 2005. Standard descriptive epidemiology was supplemented with age-period-cohort models and breast cancer survival analyses.Results: Men with breast cancer comprised less than 1% of all breast cancers. Male compared to female breast cancers occurred later in life with higher stage, lower grade, and more estrogen receptor positive tumors. Recent breast cancer incidence and mortality rates declined over time for men and women, both overall and within each age group, but these trends were greater for women than men. Comparing cases diagnosed in 1996 through 2005 versus 1976 through 1985, and adjusting for age, stage, and grade, cause-specific hazard rates for breast cancer death declined by 28% among men (p = 0.03) and by 42% among women (p ∼ 0).Conclusion: There were three intriguing results. Age-specific incidence patterns showed that the biology of male breast cancer resembled the late-onset and hormone sensitive type of female breast cancer. Similar breast cancer incidence trends among men and women suggested that there are common breast cancer risk factors that affect both sexes, especially hormone positive breast cancer. Finally, breast cancer mortality and survival rates have improved significantly over time for male breast cancer, but progress has lagged behind for men compared to women. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2075.
Anatomic Basis of Surgical Treatment of Parkinson's Disease
Authors: J. B. Carman
Journal: New England Journal of Medicine (1968)

THE treatment of Parkinson's disease has been for many years the preserve of the physician. Now, however, surgical treatment, especially when used before the disease is clinically far advanced, is playing a greater part in bringing about sufficient remission of disabling symptoms, often for periods of years, to prolong the active and self-sufficient life of the patient.The fundamental pathologic process, of unknown etiology, produces nerve-cell degeneration, principally in the globus pallidus and substantia nigra. Present treatments of the disease, whether medical or surgical, do not prevent this degeneration from progressing. They may so alter the state of balance of . . .
1017 EFFICACY OF TENOFOVIR DF TREATMENT IN PATIENTS WITH A SUBOPTIMAL RESPONSE TO ADEFOVIR DIPIVOXIL
Authors: M. Manns, J. Heathcote, P. Marcellin, T. Berg, J. Anderson, J. Sorbel, D. Frederick, F. Rousseau, K. Borroto-Esoda
Journal: Journal of Hepatology (2010)