tbuckley/cabot-search huggingface dataset:
Increased cyclic AMP levels enhance IL-1 alpha and IL-1 beta mRNA expression and protein production in human myelomonocytic cell lines and monocytes.
Authors: S S Sung, J A Walters
Journal: Journal of Clinical Investigation (1991)

The effects of increasing intracellular cAMP levels on IL-1 alpha and IL-1 beta mRNA expression and IL-1 production in human monocytes and nonlymphoid hematopoietic cell lines were examined. Peripheral monocytes and myelomonocytic cell lines could be stimulated by LPS or phorbol myristate acetate (PMA) to express IL-1 mRNA. Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone. This increase in IL-1 alpha and IL-1 beta mRNA accumulation was more modest in monocytes. The synergistic stimulation was due to enhanced IL-1 gene transcription rate rather than increased IL-1 mRNA stability. Despite this marked increase in IL-1 mRNA accumulation, IL-1 protein synthesis in these cells was increased by only twofold. Thus, IL-1 synthesis in monocytes and myelomonocytic cell lines is under stringent translational control.
Smoking and Age at Menopause in Women
Authors: SONJA M. McKINLAY
Journal: Annals of Internal Medicine (1985)

Although women can expect to live one half of their adult lives beyond menopause, knowledge about this physiologic event and its various influences on subsequent health and quality of life remains incomplete. In Massachusetts we studied a population-based random sample of 7828 white women, aged 45 to 55 years (response rate, 77%). The median age at last menstruation for the sample is 51.4 ± 0.19 (SE) years years, and we found no evidence of a secular trend towards a later age at menopause in the last 25 years. Current smokers reach menopause an average of 1.74 years earlier than nonsmokers (t = 3.78, p < 0.01), but the quantity smoked has a negligible effect. Other potential correlates measured—education and marital status, number of children, and urban/rural residence—have little effect on the age at menopause. The results confirm earlier, more tentative findings from clinical populations.
Mother to child transmission of anti- S cerevisiae mannan antibodies (ASCA) in non-IBD families Reply
Authors: D POULAIN
Journal: Gut (2000)

Editor,—We enjoyed the recent study by Sutton and colleagues ( Gut 2000; 46 :58–63) which confirmed our previous findings that elevated anti- S cerevisiae mannan antibodies (ASCA) are a familial trait in Crohn's disease.1 The lack of concordance in marital pairs indicated that familiality may be due to either a genetic factor or childhood environmental exposure. ASCA are present in 50–60% of patients with Crohn's disease, in 10–15% of patients with ulcerative colitis, and in 2–5% of control subjects.2-5 To gain more information on concordance for ASCA among family members, we studied ASCA distribution in non-inflammatory bowel disease (IBD) families.

A total …
Visualization of penetrating transmural arteries in situ by monochromatic synchrotron radiation.
Authors: H Mori, K Hyodo, K Tobita, M Chujo, Y Shinozaki, Y Sugishita, M Ando
Journal: Circulation (1994)

Penetrating transmural arteries with a diameter of < 500 microns are considered to be a critical vascular component that causes a transmural variation of myocardial blood flow under various pathophysiological conditions. However, the conventional coronary angiographic system is not oriented to the visualization of such small arteries as these.We magnified and monochromatized the inherently narrow beam (3 mm along the vertical direction) of synchrotron radiation by using an asymmetrically cut silicon crystal with 311 reflecting planes to obtain a monochromatic x-ray with relatively large beam size (60 x 25 mm) and with an energy of just above (+130 eV) the K-absorption edge of the contrast materials (33.17 and 37.41 ke V for iodine and barium, respectively). We irradiated dogs or excised hearts with the monochromatic x-ray and obtained coronary angiograms using an image intensifier and video system with a spatial resolution of 170 microns. In the anesthetized dog experiments, we visualized the transmural penetrating arteries (5 to 15 mm in length) arising every 4 to 7 mm from the epicardial branch. Visualization of these arteries filled with heavy element-loaded microspheres (15 microns in diameter) in the excised-heart experiments, in which the monochromatic x-ray was irradiated to the hearts through a 10- to 20-cm acrylic plate, indicated that this system could be used for human patients, in whom body absorption of x-ray is substantial.Coronary angiogram by means of monochromatic x-ray is useful for a precise evaluation of coronary circulation, both in clinical setting and in physiological animal experiments.
FDG PET/CT Findings of Epithelioid Sarcoma in a Pediatric Patient
Authors: Yu-Wen Chen, Ming-Yii Huang, Chin-Chuan Chang, Chuan-Shaio Lee, Yu-Mei Liao, Shyh-Shin Chiu, Tai-Tsung Chang
Journal: Clinical Nuclear Medicine (2007)

A 5-year-old girl was diagnosed with a rare trunk type of epithelioid sarcoma in the right gluteus and sacrococcygeal regions. FDG PET/CT was performed to differentiate the diagnosis of pulmonary metastasis under a massive pleural effusion on CT. Imaging revealed an extremely high grade of FDG avid activity in the right gluteus, proximal right thigh, pelvic floor and an extruding sacrococcygeal soft tissue mass. Unfortunately, FDG PET/CT not only demonstrated multiple mimicking pulmonary metastases with the massive pleural effusion, but also showed adjacent pelvic bone marrow infiltration. The advanced stage of the disease was striking.
Ankylosing Spondylitis and Aortic Regurgitation
Authors: BERNADINE H. BULKLEY, WILLIAM C. ROBERTS
Journal: Circulation (1973)

Clinical and cardiovascular necropsy findings are described in eight patients with combined ankylosing spondylitis and aortic regurgitation. All were men (aged 34-55 years), each had peripheral arthritis in addition to spondylitis, all had severe congestive failure, and six had conduction disturbances. In three patients aortic regurgitation was present before distinctive radiologic changes of ankylosing spondylitis were apparent and only two patients had advanced arthritic changes of ankylosing spondylitis. Thus, cardiac dysfunction may be present before signs of spondylitis are apparent, and aortic regurgitation may be severe when signs of spondylitis are minimal. A characteristic cardiovascular morphologic abnormality was present in each patient. The aortic valve cusps and the aorta behind and immediately above the sinuses of Valsalva were thickened, the latter by dense adventitial scar tissue and by intimal fibrous proliferation. In each patient the scar tissue in the root of aorta extended below the base of aortic valve to produce a subaortic fibrous ridge. The subaortic bump involves the base of anterior mitral leaflet and may cause mitral regurgitation. Extension of the fibrous scar into ventricular septum may cause heart block. The distinctive cardiovascular morphologic findings in patients with ankylosing spondylitis clearly separate this condition from syphilis and other entities associated with aortic regurgitation.
Studies of Plasma Quinidine Content
Authors: RICHARD W. KALMANSOHN, JOHN J. SAMPSON
Journal: Circulation (1950)

The plasma quinidine curves obtained by the oral and intramuscular routes of administration of 0.6 Gm. quinidine sulfate and 0.65 Gm. quinidine lactate, respectively, were generally similar. Maximal concentration, averaging 3.2 mg. per liter in the former group occurred from one-half hour to four hours after administration, and in the latter averaged 2.6 mg. per liter in one to three hours. Significant quantity of quinidine remained at eight hours, and small amounts at twenty-four hours. Rectal administration of 0.6 Gm. quinidine sulfate resulted in lower concentrations, the maximum averaging 0.89 mg. per liter. The chief value of intramuscular quinidine therapy appears to be the avoidance of gastrointestinal irritation, but hypotensive reactions were relatively frequent in the small series of patients studied.
Overdiagnosis and Overtreatment of Pulmonary Embolism: The Emperor May Have No Clothes
Authors: EUGENE D. ROBIN
Journal: Annals of Internal Medicine (1977)

Pulmonary embolism is being overdiagnosed and overtreated, especially in previously normal women using oral contraceptives, with undesirable consequences in heparin treatment. This is in part a consequence of high estimates of its occurrence based on postmortem data and in part of technologic developments in diagnostic methods. Blood gas data are not diagnostically very helpful. Perfusion scans should be used, largely to exclude the diagnosis. Ventilation scans are only occasionally helpful and are expensive. Pulmonary angiography is the most accurate diagnostic means currently available. Further studies are needed to elucidate the prevalence and natural life history of pulmonary embolism in the previously healthy person.
Cancer Cells Cut Homophilic Cell Adhesion Molecules and Run
Authors: Sonya E.L. Craig, Susann M. Brady-Kalnay
Journal: Cancer Research (2010)

The term contact inhibition (CI) encompasses the cellular changes that result in cessation of cell migration and of proliferation due to signals transduced when one cell comes into physical contact with another cell. Cancer cells, however, do not contact inhibit. A molecular understanding of the loss of CI in cancer cells is important for understanding tumor progression. In this Perspective, we propose that the loss of CI observed in cancer cells is the result of extracellular proteolysis of transmembrane cell-cell cell adhesion molecules (CAM) in the tumor microenvironment. Proteolysis of homophilic cell-cell CAMs results in a shed extracellular fragment and released cytoplasmic fragment(s) that disrupts adhesion and induces signals that promote proliferation and/or migration. The importance of this observation in tumor progression is supported by the presence of the shed extracellular fragments of homophilic cell-cell CAMs in serum and tumor tissue of cancer patients suggesting that instead of acting as tumor suppressors, the shed CAM extracellular and cytoplasmic fragments actually function as oncogenes. The study of cell-cell CAM cleavage will provide important and novel means of diagnosing, imaging, and treating tumor progression.
Metabolic Syndrome in Hypertensive Patients: Correlation Between Anthropometric Data and Laboratory Findings
Authors: Ticiana C. Rodrigues, Caroline K. Kramer, Thais Steemburgo, Valesca Dall'Alba, Mirela J. Azevedo
Journal: Diabetes Care (2007)

Recently, Bulhoes and Araujo (1) reported a high prevalence of metabolic syndrome in 102 Brazilian hypertensive patients, especially when using International Diabetes Federation (IDF) criteria for the metabolic syndrome (2). We have some methodological criticisms regarding their study: blood pressure levels were not described; criteria adopted for diagnosis of hypertension were not those recommended by the Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (3); and data …
HALQUINOL IN DERMATOLOGY.
Authors: M. D. READETT
Journal: British Journal of Dermatology (1965)

Journal Article HALQUINOL IN DERMATOLOGY. Get access M. D. READETT, M.B., M.R.C.P. M. D. READETT, M.B., M.R.C.P. Consultant Physician, Skin Department, Sefton General Hospital, Liverpool 15 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 11, 1 November 1965, Pages 593–595, https://doi.org/10.1111/j.1365-2133.1965.tb14583.x Published: 01 November 1965
Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses.
Authors: I Gresser, M G Tovey, C Maury, M T Bandu
Journal: The Journal of Experimental Medicine (1976)

The effect of potent sheep anti-mouse interferon globulin was investigated in several different experimental virus diseases of mice. In anti-interferon globulin-treated mice infected intraperitoneally with herpes simplex virus (HSV) type I, the latent period was shortened, and the overall LD50 was increased several hundredfold compared to virus-infected control mice. When HSV was inoculated subcutaneously all anti-interferon globulin-treated mice died, whereas only 5% of virus-infected control mice died. Subsequent treatment with anti-interferon globulin of previously HSV-infected mice did not result in reactivation of HSV. Treatment of adult mice with anti-interferon globulin resulted in an earlier appearance of MSV-induced tumors, a greater number of mice bearing tumors, an increase in tumor size, and an increase in the duration of tumors. All tumors eventually regressed despite reinjection of anti-interferon globulin. Anti-interferon globulin treatment resulted in a rapid onset of disease and death in adult mice inoculated (intranasal) with VSV and in newborn mice infected with NDV. Anti-interferon globulin exerted no effect on the course of influenza virus infection of mice. We conclude that the early production of interferon is an importane element in the response of the mouse to several viruses exhibiting different pathogeneses.
Weaning Prediction
Authors: Amal Jubran, Brydon J. B. Grant, Franco Laghi, Sairam Parthasarathy, Martin J. Tobin
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Several variables are recommended for identifying if a patient is ready for a trial of weaning from mechanical ventilation, but there is no agreement as to whether monitoring any variable during the trial enhances patient management. To determine whether repeated measurements of esophageal pressure throughout a trial are more reliable than measurements of esophageal pressure or frequency-to-VT ratio during the first minute of the trial, we studied 60 patients. A trend index that quantified esophageal pressure swings over time was more reliable than the first-minute measurements: sensitivity, 0.91, and specificity, 0.89. Area under receiver operating characteristic curve for trend index (0.94) was greater than for first-minute measurement of esophageal pressure (0.44, p < 0.05) and tended to be greater than that for frequency-to-VT ratio (0.78, p = 0.13). The likelihood ratio was highest for the trend index (8.2, p < 0.05). The advantage of the trend index may be related to the progressive increase in esophageal pressure throughout a failed weaning trial, whereas breathing pattern changed little after 2 minutes of spontaneous breathing. In conclusion, continuous monitoring of esophageal pressure swings during a spontaneous breathing trial provides additional guidance in patient management over tests used for deciding when to initiate weaning.
Human Growth Hormone Levels in Normal Subjects Receiving an Oral Contraceptive
Authors: William N. Spellacy
Journal: JAMA (1967)

Human growth hormone (HGH) levels were measured by a double antibody radioimmunoassay of plasma from women in both the fasting state, and after insulin-induced hypoglycemia. The tests were performed on 26 normal, ambulatory females'at rest, as a control, and also during the third treatment cycle with a combination-type oral contraceptive. It was found that the oral contraceptive elev[ill] the HGH levels. This would appear to be the mec[ill]m by which oral contraceptives alter carbohydrate metabolism.
THE SENSE OF TIME AND ITS RELATION TO PSYCHIATRIC ILLNESS
Authors: FRANKLIN S. DUBOIS
Journal: American Journal of Psychiatry (1954)

In a study of time from the psychological viewpoint the development, personal variation, psychodynamics, and psychopathology of the sense of time are considered. On the basis of the evidence presented the suggestion is made that a normal sense of time aids in successful adjustment while a disturbed sense of time may induce symptoms of psychopathy, psychosis, or neurosis. It is hoped that others will test this hypothesis.
Giving the Patient His Medical Record: A Proposal to Improve the System
Authors: Budd N. Shenkin, David C. Warner
Journal: New England Journal of Medicine (1973)

Dissatisfaction with the functioning of the medical-care system has become widespread. Four serious problems are maintaining high quality of care, establishing mutually satisfactory physicianpatient relations, ensuring continuity and avoiding excessive bureaucracy. We believe these problems could be alleviated, in part, if patients were given copies of all their medical records. The record to a large extent embodies the informational product of medical consultation and treatment. In most exchanges in society a purchased product becomes the property of the purchaser, who is then free to evaluate the product on his own, have it evaluated by experts and choose freely among suppliers . . .
Buckle Up! Is Not Enough
Authors: F K Winston, D R Durbin
Journal: JAMA (1999)

This article describes how, in order to further reduce child occupant injuries, the simple message of “Buckle Up!” is no longer sufficient. Improved protection of these children requires advances in knowledge regarding the risks and causes of injury to restrained children and the resultant development of appropriate practices in engineering, education, and legislation. No one disputes the need to protect children in motor vehicle (MV) crashes. The article describes how child safety seats (CSS) and safety belts are vital systems. However, as child restraint use has increased, little attention has been given to the correct fit and appropriate use of these devices.
On the continuing lack of scientific evidence for repression
Authors: Harlene Hayne, Maryanne Garry, Elizabeth F. Loftus
Journal: Behavioral and Brain Sciences (2006)

The forgetting and remembering phenomena that Erdelyi outlines here have little to do with the concept of repression. None of the research that he describes shows that it is possible for people to repress (and then recover) memories for entire, significant, and potentially emotion-laden events. In the absence of scientific evidence, we continue to challenge the validity of the concept of repression.
Accumulation of MDSC subsets in renal cell carcinoma correlates with grade and progression free survival, and is associated with intratumoral expression of IL-1β, IL-8 and CXCL5
Authors: Yana G Najjar, Patricia A Rayman, Charlie Tannenbaum, Xuefei Jia, Paul Elson, C Marcela Diaz-Montero, Tom Hamilton, Brian Rini, James Finke
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Myeloid derived suppressor cells (MDSC, CD33+CD11b+ HLA-DR low/-) play a major role in tumor-mediated immune evasion and are composed of at least 3 subsets PMN (CD15+), monocytic (CD14+) and lineage-negative (CD15-CD14-), and each has been shown to be significantly increased in
Hypercalcaemia during Vitamin D Treatment
Authors: A. E. Gremeaux
Journal: BMJ (1950)

<h3>Aim</h3> To investigate the incidence of late onset bleb-related infection (BRI) following Mitomycin C (MMC) augmented trabeculectomy procedures at a single institution. <h3>Methods</h3> This was a retrospective case series analysis of late onset BRI, defined as either blebitis or endophthalmitis occurring at least 1 month following a glaucoma filtration procedure. Data collected from hospital charts included the position of the conjunctival flap base. Two cohorts were examined: the first a sample of 194 intraoperative MMC augmented trabeculectomies undertaken over a 4-year period from 1993 to 1997, and the second a sample of 764 MMC trabeculectomies performed in a 4-year period between the years 1999 and 2005. <h3>Results</h3> A total of 11 cases of BRI (cumulative incidence 5.7%) were identified in the cohort from 1993 to 1997. BRI cases had trabeculectomies performed with a limbus-based conjunctival flap and presented at a median IQR 14.8 (9.4–42.9) months after surgery. In the 1999–2005 cohort, nine cases of BRI were identified (cumulative incidence 1.2%). All these BRI cases had a fornix-based conjunctival flap and presented at a median IQR 19.2 (6.1–44.1) months after trabeculectomy surgery. <h3>Conclusion</h3> This study found that the incidence of BRI was higher in MMC augmented trabeculectomy shortly after the introduction of MMC, but subsequently reduced to a lower level. While many changes in surgical technique had occurred in the intervening period, the most significant change was from limbus-based to fornix-based conjunctival flap. However, the retrospective nature of the study prevents the authors from concluding that there is a causative relationship between changes in surgical technique and BRI.
Cell-based Angiopoietin-1 Gene Therapy for Acute Lung Injury
Authors: Sarah D. McCarter, Shirley H. J. Mei, Patrick F. H. Lai, Qiu Wang Zhang, Colleen H. Parker, Renée S. Suen, Roberta D. Hood, Yidan D. Zhao, Yupu Deng, Robin N. N. Han, Daniel J. Dumont, Duncan J. Stewart
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

The acute respiratory distress syndrome is a significant cause of morbidity and mortality in critically ill patients. Angiopoietin-1 (Ang-1), a ligand for the endothelial Tie2 receptor, is an endothelial survival and vascular stabilization factor that reduces endothelial permeability and inhibits leukocyte-endothelium interactions.We hypothesized that Ang-1 counteracts vascular inflammation and pulmonary vascular leak in experimental acute lung injury.We used cell-based gene therapy in a rat model of ALI. Transgenic mice overexpressing Ang-1 or deficient in the Tie2 receptor were also studied to better elucidate the mechanisms of protection.The present report provides data that support a strong protective role for the Ang-1/Tie2 system in two experimental models of LPS-induced acute lung injury. In a rat model, cell-based Ang-1 gene transfer improved morphological, biochemical, and molecular indices of lung injury and inflammation. These findings were confirmed in a gain-of-function conditional, targeted transgenic mouse model, in which Ang-1 reduced endothelial cell activation and the expression of adhesion molecules, associated with a marked improvement in airspace inflammation and intraalveolar septal thickening. Moreover, heterozygous Tie2-deficient mice demonstrated enhanced evidence of lung injury and increased early mortality.These results support a critical role for the Ang-1/Tie2 axis in modulating the pulmonary vascular response to lung injury and suggest that Ang-1 therapy may represent a potential new strategy for the treatment and/or prevention of acute respiratory distress syndrome in critically ill patients.