tbuckley/cabot-search huggingface dataset:
Abstract B6: Myeloid-derived suppressor cells from melanoma patients suppress T cell proliferation and are associated with a shorter disease-free interval.
Authors: Martin D. McCarter, Kimberly Jordan
Journal: Cancer Research (2013)

Abstract Immune therapies such as vaccines, immune stimulators (IL-2), and immune checkpoint regulators (anti-CTLA-4) for melanoma elicit an initial robust immunologic response to the tumor in some patients, however, the majority ultimately go on to die of their disease. This suggests that tumor eventually develop escape mechanisms meant to evade or defeat the intrinsic immune response. Myeloid-derived suppressor cells (MDSCs) have been reported in melanoma and other cancer patients and may contribute to immune suppression or counter-regulatory responses. The aim of this project was to assess the potential role of circulating MDSCs in mediating immune suppression in advanced stage melanoma patients. Methods: MDSC populations (DC14+ Lin-HLA-DR- , Lin-HLA-DR- CD11b+ CD33+) were isolated from patients with (stage I n=20, stage IV n=35)or without (n=15) melanoma. Isolated MDSC's were mixed with allogeneic CFSE-labeled T cells for a 4 day mixed lymphocyte reaction (MLR). T cell activation and proliferation were quantified. Results: Stage IV melanoma patients have increased expression (2-3 times) of some MDSC populations (Lin-HLA-DR- CD11b+ CD33+) in the circulation compared to normal and stage I melanoma patients. By MLR, these MDSC's significantly suppressed T cell proliferation (40-50% reduction) and markers of activation (20%) to a greater extent than the same population of MDSC's for normal controls. Inhibiting nitric oxide failed to restore T-cell proliferation. A shorter disease free interval is associated with increased expression of CD33+ MDSC in the circulation. Conclusion: MDSC populations are increased in the peripheral circulation of stage IV melanoma patients and these cells actively suppress T cell proliferation. Efforts are underway to better understand the melanoma related factors responsible for the induction of MDSC's and the mechanism by which these cells suppress T-cell proliferation. Citation Format: Martin D. McCarter, Kimberly Jordan. Myeloid-derived suppressor cells from melanoma patients suppress T cell proliferation and are associated with a shorter disease-free interval. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; Dec 2-5, 2012; Miami, FL. Philadelphia (PA): AACR; Cancer Res 2013;73(1 Suppl):Abstract nr B6.
Obstructive Sleep Apnea
Authors: W. Ward Flemons
Journal: New England Journal of Medicine (2002)

A 43-year-old man presents with heavy snoring; his bed partner reports that he sometimes stops breathing while he sleeps. He has hypertension controlled by medication but is otherwise healthy. He admits to feeling sleepy at times when he drives, although he has not had any motor vehicle accidents. His body-mass index is 33, and he has a large neck circumference (46 cm). How should he be evaluated and treated?
Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients
Authors: Robert J. Morrison, Scott J. Hollister, Matthew F. Niedner, Maryam Ghadimi Mahani, Albert H. Park, Deepak K. Mehta, Richard G. Ohye, Glenn E. Green
Journal: Science Translational Medicine (2015)

Patient-specific, image-based design coupled with 3D biomaterial printing produced personalized implants for treatment of collapsed airways in patients with tracheobronchomalacia.
Cushing's Syndrome With Amelioration During Pregnancy
Authors: Randolph Lee
Journal: JAMA (1972)

A 30-year-old woman was found to have Cushing's syndrome two months prior to becoming pregnant. During her pregnancy she demonstrated both clinical and biochemical amelioration of her Cushing's syndrome starting about the 21st week of gestation and continuing to the time of delivery. At 34 weeks she was delivered of a healthy, premature female infant who is now 4 years old and thriving. About 7 months postpartum the mother again demonstrated florid hypercortisolism. At surgery, bilateral adrenocortical hyperplasia was found and a total adrenalectomy was performed. Postoperatively, the patient's clinical state gradually returned to normal. She has remained well receiving conventional hormone replacement. Women with Cushing's syndrome have difficulty in conceiving and in maintaining pregnancy. To our knowledge, this is the first report of amelioration of Cushing's syndrome during pregnancy.
Obesity, Subclinical Myocardial Injury, and Incident Heart Failure
Authors: Chiadi E. Ndumele, Josef Coresh, Mariana Lazo, Ron C. Hoogeveen, Roger S. Blumenthal, Aaron R. Folsom, Elizabeth Selvin, Christie M. Ballantyne, Vijay Nambi
Journal: JACC Heart Failure (2014)
argh... rumph... zzz... A Plea for the Medical Précis
Authors: Leo A. Gordon
Journal: JAMA (1982)

The jangling ring of a bedside telephone pierces the silence of a physician's bedroom at 2:35 AM. <h3>Physician Caller:</h3> Phil? How are you? Were you asleep? <h3>Physician Sleeper:</h3> Hello. This is Dr Warren. <h3>Physician Caller:</h3> Phil? Phil? Can you hear me? You sound awful! Do you have a cold? <h3>Physician Sleeper:</h3> Oh, Ron. No, I don't have a cold. What time is it? <h3>Physician Caller:</h3> Listen, Phil, you remember Mrs Carlyle, the car dealer's wife: She has an aunt visiting here who has a friend in Mt Pleasant. You know, Mt Pleasant was where the nursing service had their outing, ffrr..., phragh, sss.... <h3>Physician Sleeper:</h3> Ron, what is the matter? (Lapsing into unfocused somnolence, making a conscious effort to find out who he is, where he is, and what is being said to him.) <h3>Physician Caller:</h3> Phil, are you sure you don't have a cold? You sound all stuffed up.
Disproportionate Burden of Melanoma Mortality in Young US Men
Authors: David E. Fisher, Alan C. Geller
Journal: JAMA Dermatology (2013)

Unlike other preventable cancers for which mortality rates are dropping, melanoma mortality has only recently stabilized owing in large part to the unremitting increases among middle-aged and older white men, for which much attention has been paid. Gamba et al1 now focus our attention on young adults. Concentrating on US individuals from the National Cancer Institute�s Surveillance, Epidemiology, and End Results registry ages 15 to 39 years, they reveal a rather striking disparity: young men experience a 55% difference in melanoma survival compared with young women. There are many notable findings; among these, sharp sex differences in case fatality wherein young men comprise only 40% of all cases but more than 60% of all deaths. The consistency of the effect seen in 18 registries and over 20 years is quite dramatic; within all specific age groups and across all tumor thickness categories, histologic subtypes, and anatomic sites, young men experience a disproportionate burden of melanoma deaths. Similar sex disparities apparently exist in survival by the presence and extent of regional spread of disease. The findings are so consistent that they imply a fundamental biological difference in �male� vs �female� melanoma, at least for a significant fraction of patients. It is notable that the newly diagnosed melanomas were on average thicker and more advanced in men than in women. This leads to the question of whether increased mortality may have arisen from diagnostic challenges such as �missed� deep margins or later diagnosis and delay. Yet even for melanomas deeper than 4 mm, men fared more poorly than women, thereby pointing more in the direction of distinctive biology. Still, prognosis for disease with distant metastasis was essentially equally poor for men and women.
Osler's Maneuver and Pseudohypertension
Authors: Franz H. Messerli, Hector O. Ventura, Celso Amodeo
Journal: New England Journal of Medicine (1985)

We describe a simple bedside procedure (which we call "Osler's maneuver") that differentiates patients with true hypertension from those whose blood pressure is spuriously elevated because of excessive sclerosis of the large arteries ("pseudohypertension"). The maneuver is performed by assessing the palpability of the pulseless radial or brachial artery distal to a point of occlusion of the artery manually or by cuff pressure. We classified 24 elderly hypertensive patients as either Osler-positive (n = 13) or Osler-negative (n = 11), and measured their intraarterial pressure, arterial compliance, and systemic hemodynamics. Patients with pseudohypertension (Osler-positive) had falsely elevated blood-pressure readings, with a difference of 10 to 54 mm Hg between cuff and intraarterial pressure. Arterial compliance was lower in Osler-positive subjects and correlated with the difference between cuff and intraarterial pressures, indicating that the stiffer the artery, the more pronounced the degree of pseudohypertension. Pseudohypertension is common in the elderly and becomes more severe as arterial compliance decreases and sclerosis of large arteries progresses.
Expression of FcɛRI on dendritic cell subsets in peripheral blood of patients with atopic dermatitis and allergic asthma
Authors: Inge M.J. Beeren, Marjolein S. de Bruin-Weller, Chisei Ra, Ineke Kok, Carla A.F.M. Bruinzeel-Koomen, Edward F. Knol
Journal: Journal of Allergy and Clinical Immunology (2005)
Health Consequences of Declining Incomes—Reply
Authors: Steven H. Woolf
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1211 EMERGENCE AND PERSISTENCE OF NS5B MUTATIONS FOLLOWING COMBINATION TREATMENT WITH TEGOBUVIR (GS-9190) PLUS STANDARD OF CARE-LONG-TERM FOLLOW-UP FROM THE PHASE IIB STUDY GS-US-196-0103
Authors: C. Hebner, J. Harris, D. Oldach, M.D. Miller, H. Mo
Journal: Journal of Hepatology (2011)
Molecular Basis of Thyroid Hormone-Dependent Brain Development*
Authors: Jack H. Oppenheimer, Harold L. Schwartz
Journal: Endocrine Reviews (1997)

I. Introduction II. Developmental Schedules A. Species specificity B. Developmental studies in the rat III. Thyroid Hormone Action A. Sources of T4 and T3 B. The role of maternal thyroid hormone in fetal brain development: direct or indirect? C. Intracerebral transport IV. Molecular Actions of Thyroid Hormone in the Developing Brain A. Nuclear receptors for thyroid hormone in brain B. Thyroid hormone receptor isoforms and their tissue distribution C. Interactions of ligand, receptor, and DNA D. Ontogeny of thyroid hormone receptor isoforms in brain E. Search for T3-responsive genes in the neonatal rat brain F. Regulation of gene expression by T3 through indirect molecular pathways? G. Extranuclear actions of T4? V. Theories and Speculations VI. Conclusions
Therapy for primary prophylaxis of varices: And, the winner is …?
Authors: Ala I. Sharara, Don C. Rockey
Journal: Hepatology (2003)

Background & Aims: This randomized controlled trial compared variceal band ligation (VBL), propranolol (PPL), and isosorbide-5-mononitrate (ISMN) in the prevention of first esophageal variceal bleed.Methods: Over a 6-year period, 172 patients with cirrhosis, grade II or III esophageal varices that had never bled, were recruited; 44 into VBL, 66 into PPL, and 62 into ISMN.Baseline patient characteristics: age, 55 ؎ 11 years; Child-Pugh score, 8 ؎ 2; 65% alcohol-induced cirrhosis; follow-up period, 19.7 ؎ 17.6 months (range, 0.13-72.1 months), were comparable in the 3 groups.Results: On intention-to-treat analysis, variceal bleeding occurred in 7% of patients randomized to VBL, 14% to PPL, and 23% to ISMN.The 2-year actuarial risks for first variceal bleed were 6.2% (95% confidence interval [CI], 0.0%-15.0%)for VBL, 19.4% (95% CI, 0.1%-32.4%)for PPL, and 27.7% (95% CI, 14.2%-41.2%)for ISMN.A significant number of patients reported side effects with drug treatment (45% PPL and 42% ISMN vs. 2% VBL; P ‫؍‬ 0.00), resulting in withdrawal from treatment in 30% of PPL and 21% of ISMN patients.There were no statistically significant differences in mortality rates in the 3 groups.In astreated analysis, there was a statistically significant difference in actuarial risk for bleeding at 2 years between VBL and ISMN (7.5%, 95% CI, 2.5%-10.6% vs. 33.0%,95% CI, 15%-49%, respectively, log rank test P ‫؍‬ 0.03) but not between VBL and PPL.Conclusions: VBL was equivalent to PPL and superior to ISMN in preventing first variceal bleed.The side-effect profile for pharmacotherapy was considerable.
Diagnostic Value of Skin Tests and Serum Specific IgE in the Diagnosis of Immediate Hypersensitivity Reactions to Platins
Authors: Natalia I. Pérez Sánchez, Leticia Sánchez-Morillas, María Rubio-Pérez, Mercedes Cimarra, María Luisa González, Victoria Fuentes-Aparicio, Teresa Robledo Echarren, Montserrat Fernandez-Rivas
Journal: Journal of Allergy and Clinical Immunology (2015)
US doctors earn speaking and consulting fees from drug companies that sponsor their research
Authors: M. McCarthy
Journal: BMJ (2014)

Medical researchers in the United States often accept thousands of dollars in speaking and consulting payments from drug companies that also sponsor their research, the investigative journalism nonprofit organization ProPublica reported on 25 March.1

In their investigation Charles Ornstein and Ryann Grochowski Jones, reporters for ProPublica, used a searchable database called Dollars for Docs, which tracks payments made to doctors by 15 drug companies.

In their analysis the reporters looked at the payments made by nine companies in the database in 2012: Allergan, Cephalon, Eli Lilly, Forest Laboratories, GlaxoSmithKline, Merck, Novartis, Pfizer, and ViiV Healthcare.

They found that about 10% of the …
PERMANENT INJUNCTION ORDER AGAINST AMA
Authors: Susan Getzendanner
Journal: JAMA (1988)

The court conducted a lengthy trial of this case in May and June of 1987 and on August 27,1987, issued a 101 page opinion finding that the American Medical Association ("AMA") and its members participated in a conspiracy against chiropractors in violation of the nation's antitrust laws. Thereafter an opinion dated September 25, 1987 was substituted for the August 27,1987 opinion. The question now before the court is the form of injunctive relief that the court will order. See also p 83. As part of the injunctive relief to be ordered by the court against the AMA, the AMA shall be required to send a copy of this Permanent Injunction Order to each of its current members. The members of the AMA are bound by the terms of the Permanent Injunction Order if they act in concert with the AMA to violate the terms of the order. Accordingly, it is
Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse
Authors: N Petrashevskaya
Journal: Cardiovascular Research (2002)

Objective: To study the specificity of contractile phenotype and electrophysiological remodeling in transgenic (Tg) mice with cardiac directed calcineurin (phosphatase 2B) overexpression and evaluate a possible negative role of chronically activated calcineurin in β-adrenergic mediated contractile response. Methods: The patch-clamp technique was used to characterize electrophysiological properties of action potentials and inward rectifier (IK1), and transient outward potassium currents (Ito). The analysis of the contractile performance was carried out on isolated retrograde perfused hearts at constant aortic pressure. Results: Tg mice demonstrated a hypercontractile phenotype characterized by a profound β-adrenergic hypo-responsiveness at 2.0 mM [Ca2+]o. Transgenic cardiomyocytes showed marked action potential prolongation (209% in APD90) with increased Ito,peak and Isus and decreased protein expression level of Kv1.5 and Kv2.1. Lowering [Ca2+]o to 0.75 mM restored the β-adrenergic response, indicating that the calcineurin/calmodulin/adenylyl cyclase (AC) pathway may not be directly responsible for the blunted β-adrenoreceptor mediated inotropism. Conclusions: Calcineurin overexpression leads to development of a hyperdynamic phenotype with a cellular profile of increased calcium influx. This type of functional hypertrophic remodeling is accompanied by a negative feedback regulation between increased calcium handling and β-adrenergic contractile activation.
21 LOW LEVEL OF RESISTANCE, LOW VIRAL FITNESS AND ABSENCE OF RESISTANCE MUTATIONS IN BASELINE QUASISPECIES MAY CONTRIBUTE TO HIGH BARRIER TO R1626 RESISTANCE IN VIVO
Authors: S. Le Pogam, A. Seshaadri, H. Kang, A. Kosaka, S. Hu, J. Symons, K. Klumpp, N. Cammack, I. Najera
Journal: Journal of Hepatology (2008)
PERCUSSION OF THE LIVER
Authors: QAIS AL-AWQATI
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 October 1969PERCUSSION OF THE LIVERQAIS AL-AWQATI, M.B., CH.B.QAIS AL-AWQATI, M.B., CH.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-4-868_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I would like to congratulate Drs. Castell, O'Brien, Muench, and Chalmers on a very interesting article in the June 1969 issue (1). I have, however, one reservation regarding the finding that hard percussion produced smaller estimates of liver size.The percussion note is a vibration produced by the pleximeter finger. The character of the note is determined by the physical characteristics of the tissues set in vibration. The depth of travel of the vibration is proportional to its force of generation.The cupola of the diaphragm (and therefore the liver) is present at the fourth intercostal space...Reference1. CASTELLO'BRIENMUENCHCHALMERS DOKDHTC: Estimation of liver size by percussion in normal individuals. Ann. Intern. Med., 70: 1183, 1969. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Allergy and Infectious Disease The Johns Hopkins University School of Medicine Baltimore, Md. 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBuik 1 October 1969Volume 71, Issue 4Page: 868-868KeywordsLiver Issue Published: 1 October 1969 PDF DownloadLoading ...
Study of study of changes in antidepressant use after FDA warnings is not reliable
Authors: P. C. Gotzsche
Journal: BMJ (2014)

Lu and colleagues reported that suicide attempts in young people increased after the Food and Drug Administration warned that selective serotonin reuptake inhibitors (SSRIs) can increase suicidal behaviour.1 This makes no sense. The FDA’s meta-analysis of 100 000 patients in placebo controlled randomised trials found that antidepressants increase suicidal behaviour up to about age 40 years,2 and that the risk …
Relation of number of positive lymph nodes to the prognosis of patients with primary gastric adenocarcinoma.
Authors: C W Wu, M C Hsieh, S S Lo, S H Tsay, W Y Lui, F K P'eng
Journal: Gut (1996)

BACKGROUND--No nodal grouping category of gastric cancer has been universally accepted for the grading of the effectiveness of therapeutic regimens. AIMS--To establish an appropriate nodal grouping as a forecaster of distant disease and test its validity as a determinant in survival. PATIENTS--Five hundred and ten patients who underwent curative resections for gastric cancer were studied. METHODS--Retrospectively analyse the prognostic significance of the number of metastatic lymph nodes. RESULTS--A total of 17 176 lymph nodes with an average of 34 per specimen were removed, of which 2811 (16%) showed metastases. Among the 510 patients, 287 (56%) had lymph node metastases, with an average of 9.8 per metastatic case. The survival of all patients was related to their nodal status, an abrupt decrease in survival was seen between 0 and 1 and 4 compared with 5 or more modes while little difference in survival existed among 1, 2, 3, and 4, and among 5, 6, 7, and 8 positive nodes. Multivariate analysis showed that the number of positive nodes (1-4, 5-8 versus &gt; or = 9; relative risk 2.2) and depth of cancer invasion (three levels; relative risk 1.9) were independently correlated with survival. The current nodal stage was not a prognostic factor. CONCLUSIONS--Gastric cancer patients with 0, 1 to 4, 5 to 8, and &gt; 9 positive nodes may represent four appropriate prognostic groups and should be adopted for classification of nodal stage in gastric cancer.
THE ETIOLOGY AND TREATMENT OF PERNICIOUS ANEMIA
Authors: LEWELLYS F. BARKER
Journal: JAMA (1926)

A paper on this subject might, if one were pessimistically inclined, be composed of two sentences: (1) We do not know the cause of pernicious anemia, and (2) we do not, as yet, possess a cure for this disease. Though these two statements are literally true, to make them without qualification would in the existing state of knowledge be very misleading. For, as I shall attempt to show, not only have important steps toward an understanding of the etiologic factors that must be concerned in the origin of this remarkable disease been made, but also we are already in possession of a number of therapeutic measures (ameliorative and perhaps remission productive, even if not actually curative) that may advantageously be applied to patients manifesting pernicious anemia. Moreover, with the growth of our knowledge of etiology and of pathogenesis, the paths that must be followed if we are to lessen the
Remarks on the Transit of Invalids
Authors: R. Davy
Journal: BMJ (1876)

AN extended experience in the use of hammocks for invalid transit has confirmed their utility, and it is now my desire to place some additional facts on record with reference to a new stretcher .andhammock-van.Strtchers.--Thediagram shows the form of stretcher in use at the Westminster Hospital for carrying patients from the wards to the open air.(Fig. I.) The poles are placed on the shoulders, or borne at
Ornithine phenylacetate targets alterations in the expression and activity of glutamine synthase and glutaminase to reduce ammonia levels in bile duct ligated rats
Authors: M. Jover-Cobos, L. Noiret, K. Lee, V. Sharma, A. Habtesion, M. Romero-Gomez, N. Davies, R. Jalan
Journal: Journal of Hepatology (2013)