tbuckley/cabot-search huggingface dataset:
Abdominal Aortic Aneurysms in Association with Horseshoe Kidney
Authors: Joseph R. Wilder, Jules M. Koch, Alvin Stein
Journal: JAMA (1963)

HORSESHOE KIDNEY, in combination with an abdominal aortic aneurysm, is a rare and challenging problem in management. In the following case, surgery was deferred 5 yr before our treatment owing to the complexities of these combined pathologies. This paper deals with the detailed care of a patient while reviewing the salient features of diagnosis and treatment for abdominal aortic aneurysm in conjunction with horseshoe kidney. In a careful review of the literature, we were able to find only two cases with the above pathology so reported. <h3>Report of a Case</h3> In 1957 a 48-yr-old male was admitted to another hospital complaining of chest pain radiating down the left arm. An electrocardiogram (EKG) revealed ischemic changes which subsequently reverted to normal. Physical examination revealed a pulsating mass in his abdomen. A translumbar aortogram demonstrated an abdominal aortic aneurysm. Surgery was contemplated but abandoned when intravenous pyelography revealed a horseshoe kidney overlying
Multiple Painful Skin-Colored Papules—Quiz Case
Authors: Eran L. Vieregge, Angela Kyei
Journal: JAMA Dermatology (2013)

A 54-year-old woman presented with a 2-year history of a mildly pruritic, golden-brown rash that first developed on her palms and progressed to her shins and soles. The patient’s medical history and medications were unremarkable. Physical examination revealed dusky, reddish-brown patches on her bilateral soles and reddishbrown patches with scattered red puncta on the dorsum of her feet, shins, and palms (Figure 1 and Figure 2). Laboratory test results showed no abnormalities for full blood cell count, double-stranded DNA, antinuclear antibody, serum protein electrophoresis, and erythrocyte sedimentation rate. A shave biopsy specimen was obtained (Figure 3). What is your diagnosis?
The Much-Maligned Doctor
Authors: G. S. Rousseau
Journal: JAMA (1970)

My first encounter with Sir John Hill occurred in my PhD orals when an examiner asked me a question about this 18th-century figure. I had never heard of this Hill nor even seen his name in print. I remember leaving the oral, heading directly for the library, and learning, to my complete astonishment, that John Hill was a well-known apothecary, physician, botanist, geologist, antiquarian, and the author of more than 90 literary and scientific works, and—not least—a journalist whose daily column in<i>The London Advertiser and Literary Gazette</i>rendered his name a household word to Londoners of the 1750s. How then did the obscurity of this bright light of the 1750s come about? An offensive exhibition of superiority together with a highly successful career netted Hill a host of enemies, some of whom denigrated his character, after his death in 1775, by writing brief but distorted biographies. He was indeed
Support for doctors working in immigration detention centres
Authors: F. Arnold
Journal: BMJ (2015)

In recent years, colleagues and I have examined several hundred asylum seekers giving histories of torture but subjected to immigration detention. Our experience accords with numerous reports by the Prisons Inspectorate.1 We agree with Sheather and colleagues that new approaches are needed to support health professionals confronted with violation of detainees.2

Recent practice has re-traumatised many vulnerable people, who have then needed hospital admission for psychosis. …
Inhalation Scintigraphy with an Ultrafine Aerosol in Infants with Functional Bronchial Stenoses
Authors: JOACHIM KROPP, BETINA OVERBECK, J??RGEN KLUMPP, ANDREAS HOTZE, HANS-J??RGEN BIERSACK
Journal: Clinical Nuclear Medicine (1993)

Evaporation of Tc-99m pertechnetate at about 2500 degrees C on a carbon surface generates an ultrafine aerosol of Tc-99m-labeled carbon clusters (Technegas). The small particle size of about 100 nm enables the aerosol to behave similarly to a gas in its ability to penetrate. After inhalation, the radioactive particles adhere to the walls of the respiratory bronchioles and alveoli, or to the greater bronchial tubes if the airflow is not laminar. The high concentration of radioactivity in the argon carrier gas makes it possible to perform inhalation scintigraphy after only a few breaths. The authors investigated 24 infants with multiple events of bronchitis, most of whom had pneumonia. Seventeen patients had inhalation scintigraphy and bronchoscopy. Of these, 11 had scans diagnostic of bronchial stenosis and 6 had normal scans. Except for two pathologic scans, all scintigraphic findings matched well with the results of bronchoscopy. Seven patients had scintigraphy only, of which four were normal. Inhalation scintigraphy with Technegas is a reliable, nonhazardous procedure to preselect young patients for directed bronchoscopy.
Recruiting for Occupational Medicine
Authors: Ron Teichman
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 December 1989Recruiting for Occupational MedicineRon Teichman, MD, MPHRon Teichman, MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-11-953_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I read with interest the perspective by Geokas and Branson (1) regarding the recruitment of U.S. college students to medical schools. A soon to be published editorial in the Journal of Occupational Medicine titled, "Filling the Void of Well Trained Occupational Medicine Physicians: A Challenge for the 90's" (2) addresses a similar problem but at the next step, that is, attracting medical students to a career in occupational medicine.Many of the roadblocks to a career in medicine discussed by Drs. Geokas and Branson are indeed the same as are found by people studying the field of...References1. GeokasBranson MB. Recruiting students for medicine. Ann Intern Med. 1989;111:433-6. LinkGoogle Scholar2. TeichmanGoldstein RM. Filling the void of well trained occupational medicine physicians: a challenge for the 90's [Editorial]. J Occup Med. [In press]. Google Scholar3. Brandt-RaufTeichman PR. Current and future needs for occupational medicine physicians in nonindustrial settings: a survey of multispeciality group medical practices and health maintenance organizations. J Occup Med. 1988;30:928-33. CrossrefMedlineGoogle Scholar4. Summary Report of the Graduate Medical Education National Advisory Committee. Washington, D.C.: Government Printing Office; 1980. DHHS publication no. (HRA) 81-651. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: General Motors Corporation Linden, NJ 07036 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1989Volume 111, Issue 11Page: 953-954 Issue Published: 1 December 1989 PDF DownloadLoading ...
Rate-dependent changes in extracellular potassium in the rabbit atrium.
Authors: D L Kunze
Journal: Circulation Research (1977)

We measured levels of potassium ion in the extracellular space of isolated superfused rabbit atria continuously with double-barreled microelectrodes of which on barrel was a K+ liquid ion-exchanger microelectrode and the other a potential-sensing micropipette. Increases in heart rate resulted in transient increases in extracellular potassium ([K+]0). When the quiescent atrium was stimulated the maximal increase was 0.4 mM at rates of 60/min, 0.7 mM at 90/min, 0.9 mM at 120/min, 1.3 mM at 200/min, and 1.8 mM at 300/min. The increase was not sustained during continued stimulation but declined toward prestimulation levels. When the stimulus was terminated the extracellular potassium activity decreased below bathing solution values by 0.2 mM after 60/min, 0.5 mM after 90/min, 0.7 mM ater 120/min, 0.9 mM after 200/min, and 1.0 mM after 300/min and subsequently returned to a value equal to that of the bathing solution. The magnitude of the decline in extracellular potassium activity during prolonged stimulation was markedly decreased when the bathing solution contained either zero potassium, ouabain, LiCl, or a decreased Po2 such that an elevation in [K+]0 persisted during stimulation. Moreover, the reduction in [K+]0 that followed the cessation of stimulation also was inhibited. These results support a role of the Na-K pump in maintaining extracellular potassium activity during changes in cardiac rate.
An Antiapoptotic Role for Gastrin and the Gastrin/CCK-2 Receptor in Barrett’s Esophagus
Authors: Joseph C. Harris, Philip A. Clarke, Altaf Awan, Janusz Jankowski, Susan A. Watson
Journal: Cancer Research (2004)

Mechanisms by which premalignant Barrett's metaplasia (BM) progresses to esophageal adenocarcinoma are currently being sought. This study investigated the role played by the polypeptide hormone gastrin, specifically its antiapoptotic effects through activation of protein kinase B/Akt (PKB/Akt). In esophageal cell lines with low basal levels of activated PKB/Akt, phosphorylation could be induced by exogenous amidated gastrin. High basal levels of activated PKB/Akt were linked to endogenous gastrin expression and were reduced by treatment with a cholecystokinin-type 2 receptor (CCK-2R) antagonist. Expression of a constitutively active splice variant of the CCK-2R additionally increased basal activation of PKB/Akt. It is proposed that gastrin acting in an autocrine and endocrine manner via a CCK-2R isoform may activate PKB/Akt and that with expression of gastrin and CCK-2R isoforms increasing in BM samples, gastrin may aid progression of BM through amplification of antiapoptotic pathways. Evidence for this proposal was provided through the observed specific up-regulation of PKB/Akt in BM samples.
Major vault protein: A virus-induced host factor against viral replication through the induction of type-I interferon
Authors: Shi Liu, Qian Hao, Nanfang Peng, Xin Yue, Yu Wang, Yanni Chen, Jianguo Wu, Ying Zhu
Journal: Hepatology (2012)

Major vault protein (MVP) is the major constituent of vaults and is involved in multidrug resistance, nucleocytoplasmic transport, and cell signaling. However, little is known about the role of MVP during viral infections. In this study, high levels of MVP were found in peripheral blood mononuclear cells, sera, and liver tissue from patients infected with hepatitis C virus (HCV) relative to healthy individuals. HCV infections resulted in elevated levels of MVP messenger RNA (mRNA) and protein expression in the hepatocyte cell lines Huh7.5.1 and Huh7. Further studies demonstrated that the nuclear factor kappa B (NF-κB) and Sp1 pathways are involved in the induction of MVP expression by HCV. Interestingly, MVP expression suppressed HCV replication and protein synthesis by way of induction of type-I interferon mRNA expression and protein secretion. Upon investigating the mechanisms behind this event, we found that MVP enhanced the expression of interferon regulatory factor 7 (IRF7), but not IRF3. Translocation of activated IRF7 and NF-κB from the cytosol to the nucleus was involved in this process. Furthermore, vesicular stomatitis virus, influenza A virus, and enterovirus 71 also induced MVP production, and MVP in turn hampered viral replication and production.MVP is a novel virus-induced host factor and its expression up-regulates type-I interferon production, leading to cellular antiviral responses.
Dementia Induced by Methyldopa with Haloperidol
Authors: William E. Thornton
Journal: New England Journal of Medicine (1976)

Methyldopa, a frequently employed antihypertensive agent, has been shown to deplete the central nervous system of dopamine, norepinephrine, and serotonin.1 , 2 Among its Central-nervous-system side effects are excessive sedation,3 , 4 extrapyramidal reactions,5 depressions,6 7 8 9 and dementia.10 Chouinard et al. have reported the potentiation of haloperidol sedation by methyldopa in agitated and psychotic patients.11 A therapeutic benefit from a methyldopa-haloperidol combination in a psychiatric population was predicted because both agents are thought to prevent dopamine from reaching its central neurotransmitter receptor. Similar logic evokes a concern that a nonpsychiatric population may be rendered susceptible to unwanted mental effects of methyldopa when it is combined . . .
The GHESKIO Field Hospital and Clinics after the Earthquake in Haiti — Dispatch 3 from Port-au-Prince
Authors: Jean William Pape, Vanessa Rouzier, Henri Ford, Patrice Joseph, Warren D. Johnson, Daniel W. Fitzgerald
Journal: New England Journal of Medicine (2010)

After the January 12 earthquake in Haiti, the Port-au-Prince clinic of the Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO) became a refugee camp and an emergency field hospital (see slide show), in addition to remaining a clinic for patients with AIDS or tuberculosis. Our field hospital was established 7 days after the earthquake, with the arrival of a surgical team from the U.S. Department of Health and Human Services (DHHS). During the past 4 weeks, the 80-member DHHS team has seen more than 2500 patients, 40% of them less than 18 years of age. The . . .
ABC of Sports Medicine: Sport for people with disability
Authors: J C Chawla
Journal: BMJ (1994)

Sport instills self discipline, a competitive spirit, and comradeship.Its value in promoting health, physical strength, endurance, social integration, and psychological wellbeing is of little doubt.It is not difficult to understand why sport is so important for the wellbeing of people with disability.For many years disabled people have shown an interest in sport.Although opportunities for certain types of sport were available in the past, it was not until the passage of the Disabled Persons's Employment Sports available for disabled people Act in 1944 that a major initiative was taken in the United Kingdom to provide facilities to enable disabled people to overcome handicaps that * Existing sport in which disabled people arose as a consequence of their disabilities.About the same time Sir may participate with little or no modification Ludwig Guttman introduced sport as an essential part of the * Existing sport that has been modified management of patients with spinal cord damage.He described the L Sport that has been specially developed * Recreational cause deterioration of disabled people's attitudes towards themselves and * Therapeutic result in self pity, disruption of self esteem, and social isolation.An adverse * Competitive psychological reaction may be reinforced by the embarrassed attitude of the able bodied members of the community.Participation in sport can help * existing sport that has been modified (such as wheelchair basketball, Disabilities recognised for darts, javelin throwing, weightlifting); international competition * sport that has been specially developed for disabled people (such as "roll ball" for visually handicapped people, Boccia ball).* Paraplegia * Amputation * Locomotor disorders (les autres) * Cerebral palsy Competitive sport * Mental handicap Increasing interest in sport has resulted in the development of * Visual impairment competitive games.The competitive aspect of sport is important as it * Hearing impairment indicates a measure of attainment.As with sports for the able bodied, rules and regulations have been established.Different rules and classifications have been worked out for particular sports to enable disabled people to compete on equal terms.Classifications ofdisability are many and varied, some based on the cause ofdisability, others based on the parts of the body affected, such as arms, legs, heart.
TET2 is essential for survival and hematopoietic stem cell homeostasis
Authors: K Shide, T Kameda, H Shimoda, T Yamaji, H Abe, A Kamiunten, M Sekine, T Hidaka, K Katayose, Y Kubuki, S Yamamoto, T Miike, H Iwakiri, S Hasuike, K Nagata, K Marutsuka, A Iwama, T Matsuda, A Kitanaka, K Shimoda
Journal: Leukemia (2012)
Probability theory and perception of randomness: Bridging “ought” and “is”
Authors: Yanlong Sun, Hongbin Wang
Journal: Behavioral and Brain Sciences (2011)

Abstract We argue that approaches adhering to normative systems can be as fruitful as those by descriptive systems. In measuring people's perception of randomness, discrepancies between human behavior and normative models could have resulted from unknown properties of the models, and it does not necessarily lead to the conclusion that people are irrational or that the normative system has to be abandoned.
RECOMBINANT HUMAN INTERFERON ALFA-A SUPPRESSES HTLV-III REPLICATION IN VITRO
Authors: DavidD. Ho, TeresaR. Rota, JoanC. Kaplan, KevanL. Hartshorn, CharlaA. Andrews, RobertT. Schooley, MartinS. Hirsch
Journal: The Lancet (1985)
Arteriovenous Fistula of the Splenic Vessels Producing Ascites
Authors: WILLIAM G. CASSEL, JOHN A. SPITTEL, F. HENRY ELLIS, ANDREÉ J. BRUWER
Journal: Circulation (1957)

Arteriovenous fistula involving the portal vein or its tributaries is a rare condition that in some cases can be treated successfully by surgery if it is recognized. The clinical manifestations and diagnostic criteria are presented.
Th2 skewing of the immunologic development in infants with atopic dermatitis and wheezing
Authors: W.A. Neaville, C. Tisler, D. DaSilva, K. Anklum, K. Roberg, K. Carlson-Dakes, B. Anderson, A. Bhattacharya, R. Gangnon, J.E. Gern, R.F. Lemanske
Journal: Journal of Allergy and Clinical Immunology (2003)
Behavioral Psychotherapy Applications in the Medically
Authors: Jean Cottraux
Journal: Psychotherapy and Psychosomatics (1993)

Behavioral psychotherapy may promote physical health and treat some behavior-linked medical conditions. Prevention of risk factors, and relapse through self-management, the development of a healthy life-style and the possibility to use its technology in the community at a relatively low cost are emphasized. Controlled studies suggest its effectiveness in cardiovascular diseases, headaches, stuttering, alcoholism, pain and bulimia nervosa. Cancer, psychoneuroimmunology and AIDS are under investigation. Psychogeriatrics in an emerging field. More basic research is needed to establish firmly the theoretical underpinnings of behavioral medicine including a cognitive component and to extend its practice to medical staff.
Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P)
Authors: Lin Zhang, Nicole Urtz, Florian Gaertner, Kyle R. Legate, Tobias Petzold, Michael Lorenz, Alexandra Mazharian, Steve P. Watson, Steffen Massberg
Journal: Blood (2013)
Biosynthesis of Epinephrine and Norepinephrine by Sympathetic Nerves and Ganglia
Authors: MCC. GOODALL, NORMAN KIRSHNER
Journal: Circulation (1958)

It is generally believed by the neurophysiologists that the sympathetic neurohormone is norepinephrine and not epinephrine as originally supposed. This concept of norepinephrine as the sympathetic neurohormone has evolved from much impressive circumstantial evidence; however, it has not been demonstrated that the biosynthesis of norepinephrine takes place in the sympathetic nerves and ganglia. This paper shows, through the use of labeled precursors, that the sympathetic nerves and ganglia synthesize norepinephrine in a systematic sequence from tyrosine and that this synthesis apparently terminates with norepinephrine rather than progressing to the formation of epinephrine.
MRI/SPECT IMAGE FUSION
Authors: M. F. Hartshorne, L. K. Arata, B. B. Roberts, P. W. Wiest, J. A. Sanders
Journal: Clinical Nuclear Medicine (1997)

Hartshorne, M. F.*; Arata, L. K.**; Roberts, B. B.*; Wiest, P. W.*; Sanders, J. A.* Author Information
Endoglin, VEGF receptors, hypoxia inducible factor expression in liver after partial hepatectomy and effect of adenovirus-mediated gene transfer of VEGF and endostatin
Authors: D. Semela, C.A. Redaelli, B.V. Sauter, V. Schneider, J. Kovac, M. Ledermann, J-F. Dufour
Journal: Journal of Hepatology (2003)
Low-Molecular-Weight Heparin and Venous Thrombosis
Authors: Victor J. Marder
Journal: Annals of Internal Medicine (1991)

Letters15 February 1991Low-Molecular-Weight Heparin and Venous ThrombosisVictor J. Marder, MDVictor J. Marder, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-4-338_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The study by Green and colleagues (1) compared unfractionated with low-molecular-weight heparins in preventing thrombotic complications in patients with recent spinal cord injury and paralysis. The investigators suggest that low-molecular-weight heparin is superior to unfractionated heparin.In the trial, however, the three noninvasive methods dramatically failed to detect venous thrombosis accurately or reliably. First, more than half (four of seven) of the positive flow studies were falsely so, as determined by subsequent negative contrast venograms. Second, no thrombosis below the popliteal vein was noted. This finding is surprising in view of the occurrence of proximal clots, but...References1. Green D, Lee M, and Lim A. Prevention of thromboembolism after spinal cord injury using low-molecular-weight heparin. Ann Intern Med. 1990;113:571-4. LinkGoogle Scholar1. Green D, Lee M, and Lim A. Prevention of thromboembolism after spinal cord injury using low-molecular-weight heparin. Ann Intern Med. 1990;113:571-4. LinkGoogle Scholar2. O'Reilly R. Anticoagulant, antithrombotic, and thrombolytic drugs. In: Goodman Gilman A, Goodman LS, Gilman A, eds. The Pharmacological Basis of Therapeutics. 6th ed. New York: MacMillan; 1980:1352. Google Scholar1. Green D, Lee M, and Lim A. Prevention of thromboembolism after spinal cord injury using low-molecular-weight heparin. Ann Intern Med. 1990;113:571-4. LinkGoogle Scholar2. Hull R, Hirsh J, and Carter C. Diagnostic efficacy of impedance plethysmography for clinically suspected deep-vein thrombosis. Ann Intern Med. 1985;102:21-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Victor J. Marder, MDAffiliations: University of Rochester School of Medicine Rochester, NY 14642 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1991Volume 114, Issue 4Page: 338-338KeywordsHeparinLow molecular weight heparinParalysisSpinal cord injuryThrombosisVeins ePublished: 1 December 2008 Issue Published: 15 February 1991 PDF downloadLoading ...
Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production
Authors: Arya E. Mehran, Nicole M. Templeman, G. Stefano Brigidi, Gareth E. Lim, Kwan-Yi Chu, Xiaoke Hu, Jose Diego Botezelli, Ali Asadi, Bradford G. Hoffman, Timothy J. Kieffer, Shernaz X. Bamji, Susanne M. Clee, James D. Johnson
Journal: Cell Metabolism (2012)