Molecular Investigation of HIV Transmission
Authors: Gerald Myers
Journal: Annals of Internal Medicine (1994)

Editorials1 December 1994Molecular Investigation of HIV TransmissionGerald Myers, PhDGerald Myers, PhDLos Alamos National Laboratory, Los Alamos, NM 87545.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-11-199412010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In 1990, the U.S. Centers for Disease Control (CDC) and the Florida Department of Health and Rehabilitative Services announced their provisional finding that a Florida dentist with the acquired immunodeficiency syndrome (AIDS) had infected one of his patients in the course of dental surgery [1]. Not long after that, the dentist, David J. Acer, and later the patient, Kimberly Bergalis, died of complications of AIDS. By 1992, the CDC had completed the fieldwork and viral characterization, and the HIV Sequence Database and Analysis Unit at Los Alamos National Laboratory had completed the HIV genetic sequence analyses involved in the investigation ...References1. Centers for Disease Control. Possible transmission of human immunodeficiency virus to a patient during an invasive dental procedure. MMWR Morb Mortal Wkly Rep. 1990; 39:489-93. Google Scholar2. Ciesielski C, Marianos D, Ou CY, Dumbaugh R, Witte J, Berkelman R, et al. Transmission of human immunodeficiency virus in a dental practice. Ann Intern Med. 1992; 116:798-805. Google Scholar3. Ou CY, Ciesielski CA, Myers G, Bandea CI, Luo CC, Korber BT, et al. Molecular epidemiology of HIV transmission in a dental practice. Science. 1992; 256:1165-71. Google Scholar4. Hillis DM, Huelsenbeck JP. Support for dental HIV transmission. Nature. 1994; 369:24-5. Google Scholar5. Altman LK. AIDS mystery that won't go away: did a dentist infect 6 patients? New York Times; 5 July 1994: B6. Google Scholar6. Ciesielski C, Bell DM. Preventing HIV transmission in health care settings. In: Schochetman G, George JR, eds. AIDS Testing: A Comprehensive Guide to Technical, Medical, Social, Legal, and Management Issues. New York: Springer-Verlag; 1994:376-89. Google Scholar7. Chant K, Lowe D, Rubin G, Manning W, O'Donoughue R, Lyle D, et al. Patient-to-patient transmission of HIV in private surgical consulting rooms. Lancet. 1993; 342:1548-9. Google Scholar8. Bobkov A, Garaev MM, Rzhaninova A, Kaleebu P, Pitman R, Weber JN, et al. Molecular epidemiology of HIV-1 in the former Soviet Union: analysis of env V3 sequences and their correlation with epidemiologic data. AIDS. 1994; 8:619-24. Google Scholar9. Kuiken CL, Korber BTM. Epidemiological significance of intra- and inter-person variation of HIV-1. AIDS 1994; 8(Suppl 1): S27-42. Google Scholar10. Jaffe HW, McCurdy JM, Kalish ML, Liberti T, Metellus G, Bowman BH, et al. Lack of HIV transmission in the practice of a dentist with AIDS. Ann Intern Med. 1994; 121:855-9. Google Scholar11. Korber B, Myers G. Signature pattern analysis: a method for assessing viral sequence relatedness. AIDS Res Human Retroviruses. 1992; 8:1549-58. Google Scholar Author, Article, and Disclosure InformationAffiliations: Los Alamos National Laboratory, Los Alamos, NM 87545.Corresponding Author: Gerald Myers, PhD, HIV Sequence Database and Analysis Project, Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLack of HIV Transmission in the Practice of a Dentist with AIDS Harold W. Jaffe , Joyce M. McCurdy , Marcia L. Kalish , Thomas Liberti , Georges Metellus , Barbara H. Bowman , Sonia B. Richards , Annie R. Neasman , and John J. Witte The 1990 Florida Dental Investigation: The Press and the Science Carol A. Ciesielski , Donald W. Marianos , Gerald Schochetman , John J. Witte , and Harold W. Jaffe Metrics Cited ByHIV forensics: pitfalls and acceptable standards in the use of phylogenetic analysis as evidence in criminal investigations of HIV transmissionHIV Sequence Sigmatires and SimilaritiesNosocomial HIV-transmission in an outpatient clinic detected by epidemiological and phylogenetic analysesMolecular Evidence for Nosocomial Transmission of Human Immunodeficiency Virus from a Surgeon to One of His Patients11 The aids epidemic: Demographic aspects, population biology, and virus evolutionNucleic Acid Amplification Assays for Sexually Transmitted DiseasesRapid Molecular Epidemiology of Human Immunodeficiency Virus Transmission 1 December 1994Volume 121, Issue 11Page: 889-890 Issue Published: 1 December 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...