tbuckley/cabot-search huggingface dataset:
Watchdog scrutinises apparently high death rates at NHS trust
Authors: Zosia Kmietowicz
Journal: BMJ (2008)

Healthcare inspectors are launching an official investigation this week into numbers of deaths at Mid Staffordshire NHS Foundation Trust, which they suspect may be excessively high, particularly among patients admitted as emergencies.

The Healthcare Commission said that it was alerted last September to possible problems in the trust’s systems for monitoring mortality. Since then it had visited the trust twice and found that its death rates were higher than those in similar trusts in England. 

However, the commission refused to say which time period was being investigated or to …
TCT-246 Comparison of intravascular ultrasound versus angiography guided drug-eluting stent implantation: a meta-analysis of randomized trials and observational studies involving 17,570 patients
Authors: Yaojun Zhang, Christos Bourantas, Shaoliang Chen, Vasim Farooq, Hector Garcia-Garcia, Patrick Serruys
Journal: Journal of the American College of Cardiology (2012)
Missing Clinical Information
Authors: Nancy C. Elder, John Hickner
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CD8+ T Lymphocytes in Bronchiolitis Obliterans, Paraneoplastic Pemphigus, and Solitary Castleman's Disease
Authors: Mark A. Hoffman, Xiaoying Qiao, Grant J. Anhalt
Journal: New England Journal of Medicine (2003)

To the Editor: Paraneoplastic pemphigus has been reported in patients with Castleman's disease, and bronchiolitis obliterans in association with paraneoplastic pemphigus can eventuate in respirator...
Effect of prolonged exercise of serum testosterone levels in adult men.
Authors: R. J. Young, A. H. Ismail, A. Bradley, D. L. Corrigan
Journal: British Journal of Sports Medicine (1976)

The purpose of the study was to: 1) identify the differences in serum testosterone levels among four groups of adult men differentiated on the basis of physical fitness and age, and 2) determine the effect of a four-month physical fitness programme consisting of running, calisthenics and recreational activities on the serum testosterone levels of the four groups. The groups were designated: high-fit, young aged about 32 (n = 7); high-fit, old aged about 52 (n = 7); low-fit, young (n = 7), and low-fit, old (n = 7). The subjects were selected and grouped according to physical fitness scores obtained using the regression equation of Ismail et al. Serum testosterone was determined by a radioimmunoassay method. The pre-test ANOVA revealed that the high-fit groups had a significantly (p less than .01) higher testosterone level (754.29 ng/100 ml) than the low-fit groups (548.07 ng/100 ml) and the high-fit, young group (925.01 ng/100 ml) was significantly (p less than .01) higher than the other three groups. Post-test values were adjusted using pre-test testosterone values as covariates. No significant differences among the groups were found indicating that the serum testosterone levels were the same regardless of different ages and fitness levels. The findings were discussed in light of physiological, biochemical and psychological factors.
Identification of p70 and p80 Associations With Class II MHC Molecules and I<sub>i</sub>
Authors: Christopher H. Sorli, Patricia S. Reisert, Robert E. Humphreys, William J. Welch
Journal: American Journal of Hematology (1990)

Abstract Two proteins, p70 and p80, were found in chemically crosslinked complexes with class II MHC molecules and I i after 3–12 hr labelings with [ 35 S]methionine. Two‐dimensional, nonreduced/reduced SDS gel electrophoresis of immunoprecipitated complexes revealed 1) endogenous disulfide linkages between I i ‐I i and I i ‐p70 and 2) chemically crosslinked, nearest neighbors of α‐β, α‐I i , I i ‐p70, and α‐p80. Although such nearest neighbors within multimeric complexes were identified as dimers in nonreduced/reduced 2D gels, stoichiometries could not be determined in the high molecular weight complex(es), which included α, β, I i , p70, and p80, and were not separated in the first dimension. p80 was not the chondroitin‐sulfate form of I i (I i ‐CS) because it was not electrophoretically heterogeneous and was not sensitive to chondroitinase ABC. p70 was not hsp72/74 detected with C92 or N27 mAbs, and p80 was not BiP detected with its respective mAb. While only these two proteins associated prominently with class II MHC antigens and I i late after synthesis, their functions are unknown.
Isolation and transcriptome analyses of human erythroid progenitors: BFU-E and CFU-E
Authors: Jie Li, John Hale, Pooja Bhagia, Fumin Xue, Lixiang Chen, Julie Jaffray, Hongxia Yan, Joseph Lane, Patrick G. Gallagher, Narla Mohandas, Jing Liu, Xiuli An
Journal: Blood (2014)
Supplementary Prognostic Variables for Pleural Mesothelioma: A Report from the IASLC Staging Committee
Authors: Harvey I. Pass, Dorothy Giroux, Catherine Kennedy, Enrico Ruffini, Ayten K. Cangir, David Rice, Hisao Asamura, David Waller, John Edwards, Walter Weder, Hans Hoffmann, Jan P. van Meerbeeck, Valerie W. Rusch
Journal: Journal of Thoracic Oncology (2014)

The staging system for malignant pleural mesothelioma is controversial. To revise this system, the International Association for the Study of Lung Cancer Staging Committee developed an international database. This report analyzes prognostic variables in a surgical population, which are supplementary to previously published CORE variables (stage, histology, sex, age, and type of procedure).Supplementary prognostic variables were studied in three scenarios: (1) all data available, that is, patient pathologically staged and other CORE variables available (2) only clinical staging available along with CORE variables, and (3) only age, sex, histology, and laboratory parameters are known. Survival was analyzed by Kaplan-Meier, prognostic factors by log rank and stepwise Cox regression modeling after elimination of nonsignificant variables. p value less than 0.05 was significant.A total of 2141 patients with best tumor, node, metastasis (TNM) stages (pathologic with/without clinical staging) had nonmissing age, sex, histology, and type of surgical procedure. Three prognostic models were defined. Scenario A (all parameters): best pathologic stage, histology, sex, age, type of surgery, adjuvant treatment, white blood cell count (WBC) (≥15.5 or not), and platelets (≥400 k or not) (n = 550). Scenario B (no surgical staging): clinical stage, histology, sex, age, type of surgery, adjuvant treatment, WBC, hemoglobin (<14.6 or not), and platelets (n = 627). Scenario C (limited data): histology, sex, age, WBC, hemoglobin, and platelets (n = 906).Refinement of these models could define not only the appropriate patient preoperatively for best outcomes after cytoreductive surgery but also stratify surgically treated patients after clinical and pathologic staging who do or do not receive adjuvant therapy.
Effects of Ramipril and Vitamin E on Atherosclerosis
Authors: Eva M. Lonn, Salim Yusuf, Vladimir Dzavik, C. Ian Doris, Qilong Yi, Sandra Smith, Anne Moore-Cox, Jackie Bosch, Ward A. Riley, Koon K. Teo
Journal: Circulation (2001)

Background —Activation of the renin-angiotensin-aldosterone system and oxidative modification of LDL cholesterol play important roles in atherosclerosis. The Study to Evaluate Carotid Ultrasound changes in patients treated with Ramipril and vitamin E (SECURE), a substudy of the Heart Outcomes Prevention Evaluation (HOPE) trial, was a prospective, double-blind, 3×2 factorial design trial that evaluated the effects of long-term treatment with the angiotensin-converting enzyme inhibitor ramipril and vitamin E on atherosclerosis progression in high-risk patients. Methods and Results —A total of 732 patients ≥55 years of age who had vascular disease or diabetes and at least one other risk factor and who did not have heart failure or a low left ventricular ejection fraction were randomly assigned to receive ramipril 2.5 mg/d or 10 mg/d and vitamin E (RRR-α-tocopheryl acetate) 400 IU/d or their matching placebos. Average follow-up was 4.5 years. Atherosclerosis progression was evaluated by B-mode carotid ultrasound. The progression slope of the mean maximum carotid intimal medial thickness was 0.0217 mm/year in the placebo group, 0.0180 mm/year in the ramipril 2.5 mg/d group, and 0.0137 mm/year in the ramipril 10 mg/d group ( P =0.033). There were no differences in atherosclerosis progression rates between patients on vitamin E and those on placebo. Conclusions —Long-term treatment with ramipril had a beneficial effect on atherosclerosis progression. Vitamin E had a neutral effect on atherosclerosis progression.
Case 13-1962
Authors: H. Walter Jones
Journal: New England Journal of Medicine (1962)

Presentation of Case First admission. A sixty-one-year-old man entered the hospital because of hypertension and dyspnea.The patient was known to have high blood pressure, with mild exertional dyspnea and ankle edema, for fourteen months previously. Four months before admission slight paroxysmal nocturnal dyspnea, malaise, anorexia and increased ankle edema developed. Digitalis and mercurial diuretics afforded partial relief. There was a single episode of diffuse, moderately severe pain in the anterior portion of the chest that disappeared spontaneously after one hour.There was no history of syphilis or rheumatic fever. He smoked 3 packages of cigarettes daily and drank . . .
Circulating Microemboli in Patients After Aortic Valve Replacement With Pulmonary Autografts and Mechanical Valve Prostheses
Authors: Axel Nötzold, Dirk W. Droste, Gunnar Hagedorn, Suliko Berndt, Manfred Kaps, Bernhard Graf, Hans H. Sievers
Journal: Circulation (1997)

Background The pulmonary autograft procedure (Ross) is now considered the gold standard for aortic valve replacement. One of its advantages is the freedom from macroemboli without anticoagulation. Whether this holds true for circulating microemboli, detectable as high-intensity transient Doppler signals (HITS), has not yet been verified. Methods and Results We investigated 8 patients (2 women, 6 men; mean age, 50.6±17.9 years) after the Ross procedure, 9 patients (3 women, 6 men; mean age, 67.2±9.46 years) after aortic valve replacement with a mechanical valve prosthesis, and 12 young healthy volunteers by unilateral 1-hour recording of the middle cerebral artery on digital audio tape. Patients with extracranial carotid artery disease were excluded by color duplex sonography. During the off-line evaluation, the investigator was not aware of any patient details. No HITS were detected in healthy volunteers (95% confidence interval [CI], 0% to 26.46%). After the Ross procedure, 1 patient had 11 and 1 patient had 1 HITS (95% CI, 3.19% to 65.09%). All recipients of mechanical valves had HITS, ranging from 2 to 84 per hour (95% CI, 66.7% to 100%). Significantly more recipients of mechanical valves exhibited HITS than recipients of pulmonary autografts ( P &lt;.05) or control subjects ( P &lt;.05). Conclusions In contrast to mechanical valves, pulmonary autografts are seldom the source of microemboli, confirming the pulmonary autograft as the superior substitute for aortic valve replacement.
Chronic Hepatitis B — New Goals, New Treatment
Authors: Ching-Lung Lai, Man-Fung Yuen
Journal: New England Journal of Medicine (2008)

The hepatitis B virus (HBV) causes chronic infection in approximately 400 million people in the world. Most carriers of chronic HBV, including Asians, Africans, and a proportion of persons in Mediterranean countries, acquire the infection at birth or within the first 1 to 2 years after birth.1 It is estimated that 50% of male carriers and 14% of female carriers will eventually die of the complications of cirrhosis and hepatocellular carcinoma.2 The criteria and end points for the treatment of chronic HBV infection should be reevaluated in light of three important recent findings. First, more than 70% of patients with . . .
Ambulatory Medical Care
Authors: Jay Noren, Todd Frazier, Isidore Altman, James DeLozier
Journal: New England Journal of Medicine (1980)

We analyzed data from the National Ambulatory Medical Care Survey to compare the style of practice of two primary-care providers, general internists and family-general practitioners. Whereas internists spent 18.4 minutes with the average patient, family-general practitioners spent 13.0 minutes. Whereas internists used laboratory tests in 73 per cent of visits and x-ray tests in 53 per cent, family-general practitioners used these studies in 34 and 19 per cent of visits. Internists provided instructions regarding health problems in 17.8 per cent of visits, and family-general practitioners in 12.4 per cent. The two provider groups did not differ in terms of therapy for emotional problems, both providing it in a relatively low proportion of visits (3 per cent). Whether by choice or necessity, family-general practitioners spent less time examining and instructing patients, and they ordered fewer laboratory and x-ray studies. The implications of these differences for the cost and quality of primary care need further study.
Unusual Exercise-related Stress Fractures Two Case Reports
Authors: D M FINK-BENNETT, M T BENSON
Journal: Clinical Nuclear Medicine (1984)

We describe two unusual exercise-related stress fractures, one in the sacroiliac joint of a long distance runner, the other in the body of the scapulae of an aboveknee amputee. Each were detected on a 2-hour delay bone scan. To our knowledge, neither have been described scintigraphically. The bilateral scapular fracture is an unreported entity, and the fractured SI joint is a very uncommon site for an overuse injury.
Transplanted cord blood–derived endothelial precursor cells augment postnatal neovascularization
Authors: Toyoaki Murohara, Hisao Ikeda, Junli Duan, Satoshi Shintani, Ken-ichiro Sasaki, Hiroyuki Eguchi, Ichiro Onitsuka, Kazuo Matsui, Tsutomu Imaizumi
Journal: Journal of Clinical Investigation (2000)

Endothelial precursor cells (EPCs) have been identified in adult peripheral blood. We examined whether EPCs could be isolated from umbilical cord blood, a rich source for hematopoietic progenitors, and whether in vivo transplantation of EPCs could modulate postnatal neovascularization. Numerous cell clusters, spindle-shaped and attaching (AT) cells, and cord-like structures developed from culture of cord blood mononuclear cells (MNCs). Fluorescence-trace experiments revealed that cell clusters, AT cells, and cord-like structures predominantly were derived from CD34-positive MNCs (MNCCD34+). AT cells and cell clusters could be generated more efficiently from cord blood MNCs than from adult peripheral blood MNCs. AT cells incorporated acetylated-LDL, released nitric oxide, and expressed KDR, VE-cadherin, CD31, and von Willebrand factor but not CD45. Locally transplanted AT cells survived and participated in capillary networks in the ischemic tissues of immunodeficient nude rats in vivo. AT cells thus had multiple endothelial phenotypes and were defined as a major population of EPCs. Furthermore, laser Doppler and immunohistochemical analyses revealed that EPC transplantation quantitatively augmented neovascularization and blood flow in the ischemic hindlimb. In conclusion, umbilical cord blood is a valuable source of EPCs, and transplantation of cord blood–derived EPCs represents a promising strategy for modulating postnatal neovascularization.
Healing Hands: Customizing Your Health Team for Institutional Survival—A Review and Analysis of Multiskilled Health Practitioner Education and Employment
Authors: Hannah L. Hedrick
Journal: JAMA (1992)

Based on its belief that the demand for greater efficiency, productivity, and continuity of care will be heightened as the United States approaches the year 2000, the W. K. Kellogg Foundation and the federal government have for 15 years provided support for developing a variety of education and practice models for "multiskilled health practitioners."<i>Healing Hands</i>reports on the concepts and applications of multicompetency preparation, which provides practitioners with skills and clinical experiences to fulfill the practice roles of two or more traditional health occupations. The National Multiskilled Health Practitioner Clearinghouse, established in September 1987 at the University of Alabama at Birmingham's School of Health Related Professions, which maintains files on more than 75 multiskilled educational programs and 140 hospital and medical center practice sites, is acknowledged for its leadership role in developing multicompetent health practitioner educational programs and publications and in promoting the concept of linkages between education and
924. High Transgene Expression Efficiency Does Not Directly Reflect High Plasmid DNA Uptake Efficiency: Comparison between Skeletal and Cardiac Muscle
Authors: N. Sarkar, T. Gustavsson, A. Freyschuss, B. Norman, A. Wiik, P. Blomberg, V. Drvota, C. Sylven
Journal: Molecular Therapy (2005)

Background and Aim: Although both skeletal and cardiac muscles have a remarkable ability to take up and express plasmid DNA after intramuscular injection, gene expression has been reported to be lower in skeletal muscle. The aim of this study was to detect differences in plasmid uptake efficiency.
Training in accident and emergency: views of senior house officers.
Authors: F Morris, A Cope, S Hawes
Journal: BMJ (1990)

Data on 50 patients infected with HIV* No with No with No with Mean CD4+ epilepsy or No with alcohol No with clinical No of Kaposi's opportunistic lymphocytes Mean HIV p24 taking consumption or radiological patients sarcoma infections (x lO6/l) antigen (U/1) anticonvulsants >2 units/day hepatomegaly Patients with Dupuytren's contracture 18 6 15 59 152 000 1 3 5 Bilateral 9 3 7 43 121 000 2 2 Unilateral 9 3 8 75 182 000 1 1 3 Patients without Dupuytren's contracture 32 11 25 52 75 000 2 5 4 Total 50 17 40 54 103 000 3 8 9 *None of the patients had diabetes mellitus.consumption, history of epilepsy or diabetes mellitus, and use of anticonvulsant drugs were no more common in those with Dupuytren's contractures (Student's t test).The presence of Dupuytren's contracture was not correlated with immunological function as measured by absolute CD4+ lymphocyte count, concentration of p24 antigen, time since HIV antibody was first detected, particular opportunistic infections, any drug, or tumours associated with HIV.
Adult Supraglottitis (Epiglottitis)
Authors: Ann Sullivan Baker, Roland D. Eavey
Journal: New England Journal of Medicine (1986)

FEW diseases are as potentially tragic as supraglottitis (also termed epiglottitis). A healthy person can die of asphyxia from swollen tissues that are only a few millimeters from the direct view of a physician.1 The paper in this issue of the fournal by MayoSmith et al.2 focuses our attention on the fact that supraglottitis is not just a disease of children.Most of the supraglottic laryngeal and contiguous tissues, from the vallecula to the arytenoids, are usually involved by the infection in epiglottitis. In fact, the epiglottis can sometimes even be spared amid this general inflammation. The literature seldom refers . . .
Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn® H40, poly(l-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery
Authors: Mani Prabaharan, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, Shaoqin Gong
Journal: Biomaterials (2009)
The Exposure of Health Care Workers to Ribavirin Aerosol
Authors: Melvin I. Marks
Journal: JAMA (1989)

<h3>To the Editor.—</h3> We have several questions about the interesting letter "Exposure of Health Care Workers to Ribavirin Aerosol."<sup>1</sup>The authors suggest that a University of California at San Francisco-appointed task force reached conclusions dramatically modifying the treatment of hospitalized patients with respiratory syncytial virus infections. This is a very important decision, and the data on which it is made should be available. It is unclear whether the task force recommendations were made for a specific hospital or for all hospitals. Either way, restricting ribavirin aerosol to administration via an endotracheal tube is of great concern. Having recently completed a review of ribavirin use in more than 22 000 infants in the United States since 1986, we are unclear about the database on which the task force drew its conclusions about safety. Our review indicated no major toxic effects among patients or personnel and an adverse drug reaction rate
The Tyranny of Health
Authors: F T Fitzgerald
Journal: New England Journal of Medicine (1994)

There has recently been much in both lay and medical literature on the promotion of healthy lifestyles. Once upon a time people did not have lifestyles; they had lives. Those lives were filled with work and play, battle and respite, excitement and boredom, but principally with the day-to-day struggle for existence, centered largely around the family, birth, death, disease, and health. What is the difference between a lifestyle and a life? Central to it, I believe, is the concept that lifestyle is something one chooses, and life is something that happens to one. This distinction will affect the future of . . .
Policies on antibiotics of south east London general practitioners for managing acute otitis media in children.
Authors: R P Mills
Journal: BMJ (1984)

Questionnaires on antibiotic treatment of acute otitis media in children were sent to the general practitioners who make regular referrals to clinics in the King's College Hospital group. The most popular first choice of drug was amoxycillin (44%), but 37% of general practitioners said that they often used oral phenoxymethylpenicillin. This drug has relatively low activity against Haemophilus influenzae and many strains of Staphylococcus aureus. It is poorly absorbed from the stomach, does not penetrate the middle ear well, and its use may be one factor in the development of chronic middle ear effusions after acute otitis media. Sixty two per cent of the doctors who replied never treated acute otitis media with intramuscular antibiotics, but 57% used oral loading doses. Ninety seven per cent never treated their patients without antibiotics.