tbuckley/cabot-search huggingface dataset:
Autoradiographic characterization of beta-adrenergic receptor subtype in the canine conduction system.
Authors: K H Muntz
Journal: Circulation Research (1992)

It has been hypothesized, based on physiological evidence, that there is a greater proportion of beta 2-adrenergic receptors on the myocytes of the conduction system when compared with the working myocardium. The purpose of these studies was to examine beta-adrenergic receptor subtype in the conduction system of the dog by using the technique of coverslip autoradiography. Scintillation studies of [125I]pindolol binding to ventricular sections demonstrated that binding was saturable (dissociation constant of 116 pM), had the correct order of potency for a beta-receptor, and was stereoselective. Both betaxolol (beta 1-selective) and ICI-118,551 (beta 2-selective) competition curves fit a two-site model in nonlinear curve-fitting analyses (78% beta 1-receptors). Autoradiographic studies determined that the myocytes of the sinoatrial node had approximately twice as many autoradiographic grains as the surrounding atrial myocytes. The myocytes of the atrioventricular bundle had a number of grains similar to the number in surrounding septal myocytes. Autoradiographic inhibition curves with betaxolol or ICI-118,551 demonstrated that both the sinoatrial node and the atrioventricular bundle had inhibition profiles similar to the surrounding myocytes (predominantly beta 1) but unlike the inhibition profiles of arterioles (predominantly beta 2). Calculations using the dissociation constants derived from the nonlinear curve-fitting analysis and the percent specific binding in the presence of 4 x 10(-7) M betaxolol or ICI-118,551 determined that the proportion of beta 1- to beta 2-receptors was the same (70-80% beta 1) when comparing the sinoatrial node and the surrounding atrial myocytes.(ABSTRACT TRUNCATED AT 250 WORDS)
Chelation Therapy in Atherosclerosis
Authors: JAMES G. STEVENSON
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 November 1982Chelation Therapy in AtherosclerosisJAMES G. STEVENSON, PHARM.D., TIMOTHY R. COVINGTON, PHARM.D.JAMES G. STEVENSON, PHARM.D.Search for more papers by this author, TIMOTHY R. COVINGTON, PHARM.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-5-789_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A number of inquiries have been made to the West Virginia University Drug Information Center requesting information on the value of edetate disodium (EDTA) in chelation therapy of atherosclerosis, angina pectoris, and related disorders. The American Academy of Medical Preventics (AAMP) has been distributing information on this subject to the public. We would like to alert physicians and other health professionals to the misleading claims made by this group and clarify the status of EDTA chelation therapy.The AAMP has suggested that patients with atherosclerotic disease complete a "computer-analyzed" medical history questionnaire, have a "trace mineral analysis"...References1. CLARKECLARKEMOSHER NCR. Treatment of angina pectoris with disodium ethylene diamine tetraacetic acid. Am J Med Sci. 1956;230:654-66. CrossrefGoogle Scholar2. SOFFER A. Chelation therapy for atherosclerosis. JAMA. 1975;233:1206-7. CrossrefMedlineGoogle Scholar3. CRAVENMORELLI PH. Chelation therapy. West J Med. 1975;122:277-8. MedlineGoogle Scholar4. KITCHELIPALMONAYTANMELTZER JFNL. The treatment of coronary artery disease with disodium EDTA: a reappraisal. Am J Cardiol. 1963;11:501-6. CrossrefMedlineGoogle Scholar5. Edetate disodium. In: MCEVOY GK, ed. American Hospital Formulary Service, Vol. 2. Bethesda: American Society of Hospital Pharmacists; 1977. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES G. STEVENSON, PHARM.D.; TIMOTHY R. COVINGTON, PHARM.D.Affiliations: West Virginia University Mogantown, WV 26506 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInefficacy of EDTA Chelation Therapy for Coronary AtherosclerosisUnproved Modality in the Treatment of Alzheimer-Type DementiaChelation Therapy of Atherosclerosis 1 November 1982Volume 97, Issue 5Page: 789-790KeywordsAnginaAtherosclerosisComputersDrug informationEthylenediaminetetraacetic acidQuestionnaires ePublished: 1 December 2008 Issue Published: 1 November 1982 PDF downloadLoading ...
PERIODONTAL DISEASE ACTS SYNERGISTICALLY WITH SYSTEMIC INFLAMMATION ON ASYMMETRIC DIMETHYLARGININE IN HYPERTENSIVE PATIENTS: EVIDENCE OF A DOSE-DEPENDENT EFFECT
Authors: C. Thomopoulos, K. Tsioufis, N. Soldatos, I. Andrikou, L. Lioni, A. Kordalis, A. Kasiakogias, T. Makris, C. Stefanadis
Journal: Journal of the American College of Cardiology (2011)
One-View Follow-up Mammogram
Authors: Daniel S. Cukier
Journal: JAMA (1977)

To determine whether one-view mammography would be sufficiently diagnostic, 106 cases of breast cancer diagnosed by film mammography or xeromammography were reviewed independently by two radiologists. Detection rates were analyzed for the lateral view, the craniocaudal view, and then both views combined. The lateral projection resulted in an accuracy rate of 97%. Errors in false-negative reports in either projection were traced to their source.
2012 Theme Issue on Comparative Effectiveness Research—Call for Papers
Authors: Robert M. Golub
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV–HBV Coinfection — A Global Challenge
Authors: Athena P. Kourtis, Marc Bulterys, Dale J. Hu, Denise J. Jamieson
Journal: New England Journal of Medicine (2012)

Human immunodeficiency virus and hepatitis B virus exact a high toll worldwide. Both can lead to chronic disease, cancer, and death, and neither can be eradicated with the use of current therapies. Coinfection with the two viruses represents a major global health problem.
PATHOGENESIS OF COXSACKIE VIRUS INFECTION
Authors: Joseph L. Melnick, Gabriel C. Godman
Journal: The Journal of Experimental Medicine (1951)

The quantitative distribution of the Conn.-5 strain of Coxsackie virus in different tissues was determined by serial titration at intervals after inoculation of 4 to 5 day old mice. High titers were reached by the 2nd day in blood, heart, liver, muscle, intestine, and its contents, and these were maintained through the 8th day, except for the blood, in which the virus level fell earlier. In paralyzed mice, muscle and brain attained the highest titers and it was in these tissues alone that virus persisted through the 9th day of illness. The pathology of the infection has been briefly described. In particular, the evolution of morbid changes in striated muscle was correlated with the concentrations of virus in muscle. Acute muscle necrosis first occurred when there was a peak viral concentration (4th day), and reached maximal intensity on the 8th day. Scattered acute lesions continued to appear while the virus titer remained above 10(-4), from the 9th to 12th day. With the decrease in the myositis, there was a concomitant decrease in the incidence of perceptible disease. Inflammation was found to follow upon the development of necrosis, and subsided slowly. Regeneration began very early, became exuberant, and led finally to restitution of the muscle.
Ramipril improved walking times and QOL in peripheral artery disease and intermittent claudication
Authors: Bernard G. Jaar
Journal: Annals of Internal Medicine (2013)

Source Citation THIS ARTICLE HAS BEEN RETRACTED. Ahimastos AA, Walker PJ, Askew C, et al. Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA. 2013;309:453-60. 23385271
The early days of transplantation
Authors: T. E. Starzl
Journal: JAMA (1994)

Although the fantasy of performing tissue and limb transplantation can be traced to antiquity, not until this century was the possibility of engrafting vital organs broached. The attempt began with failed kidney xenograft trials in Europe,1 followed by the first recorded attempt at a renal allograft in 1936 by the Russian physician Y. Y. Voronoy. The modern era of transplantation truly began in 1944, when Peter Medawar demonstrated that allograft rejection is an immunologic process.
Science and Morality: New Directions in Bioethics
Authors: James M. Humber
Journal: JAMA (1982)

This anthology is a compilation of papers delivered at three annual science and morality conferences held at Nazareth College of Rochester during 1979, 1980, and 1981. The collection begins with an introductory essay, which is intended to serve as an overview of the field. The text is divided into three parts, with the essays in each part centering on issues related to one specific phase of the life cycle. Part 1, Interventions at the Beginning of Life, deals with issues such as genetic counseling, in vitro fertilization, and eugenics. Part 2, Interventions During the Life Cycle, is concerned with environmental issues, patient rights, behavior modification, and similar topics. Part 3, Interventions at the End of Life, deals with treatment of the aged, euthanasia, and death. The three parts of the text are not evenly balanced; there are nine essays in part 1, five in part 2, and six in part
STUDIES ON THE PREVENTION OF RHEUMATIC FEVER: THE EFFECT OF TIME OF INITIATION OF TREATMENT OF STREPTOCOCCAL INFECTIONS ON THE IMMUNE RESPONSE OF THE HOST 1
Authors: Loring L. Brock, Alan C. Siegel
Journal: Journal of Clinical Investigation (1953)

Previous studies have established the fact that penicillin treatment of acute streptococcal pharyn- gitis results in a marked suppression of antibody formation (1, 2, 3).This is in contrast to the fail- ure of penicillin treatment to alter the immune re- sponse in patients with pneumococcal pneumonia (4).It has been suggested that in the latter case, sufficient pneumococcal antigen is formed during the early phases of pneumonia to provide a maximal antigenic challenge before penicillin therapy is in-
Response to Comment on Stegman et al. High-Intensity Statin Therapy Alters the Natural History of Diabetic Coronary Atherosclerosis: Insights From SATURN. Diabetes Care 2014;37:3114–3120
Authors: Brian Stegman, Rishi Puri, Mingyuan Shao, Stephen J. Nicholls
Journal: Diabetes Care (2015)

We appreciate interest of Drs. Huang and Chen (1) in our article (2). We agree that the diabetic population is heterogeneous in terms of cardiovascular risk, with varying comorbidities and duration and severity of diabetes per se. However, we disagree with the notion of the Study of Coronary Atheroma by Intravascular Ultrasound: Effect of Rosuvastatin Versus Atorvastatin (SATURN) cohort representing a purely low-risk population, as study inclusion required the presence of symptomatic coronary artery disease. Furthermore, 30% of the SATURN population was enrolled following an acute coronary syndrome (ACS) and 23% had a history of previous myocardial infarction. With regard to the relative low frequency of …
Comparison of intraperitoneal and subcutaneous insulin administration on lipids, apolipoproteins, fuel metabolites, and hormones in type I diabetes mellitus
Authors: Jean-Louis Selam, Moti Kashyap, KGMM Alberti, James Lozano, Michael Hanna, Dee Turner, Nathalie Jeandidier, Eve Chan, M.Arthur Charles
Journal: Metabolism (1989)
INTRAPERITONEAL AND INTRACEREBRAL ROUTES IN SERUM PROTECTION TESTS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS
Authors: Peter K. Olitsky, Carl G. Harford
Journal: The Journal of Experimental Medicine (1938)

Young (12 to 15 day old) mice are approximately as susceptible to the virus of equine encephalomyelitis, Eastern or Western strain, when it is given intraperitoneally as are adult mice when the virus is injected intracerebrally. With this susceptibility by the intraperitoneal route as a basis, the injection of immune serum-virus mixtures intraperitoneally was found to result in protection in dilutions which give rise to infection after intracerebral inoculation. The difference of protective power by the two indicated routes was shown not to depend on the amount of inoculum nor on the age of the intracerebrally injected mice. Incubation at 37 degrees C. for 2(1/2) hours neither increases nor diminishes the protective action of immune serum when the intraperitoneal method is employed. The phenomenon of selective protection in different tissues is elicited by the sera of hyperimmunized mice, guinea pigs, and rabbits and by sera derived from horses infected with the disease in nature or exposed to it by contact. Of four horses recovered from the malady, all showed antibody in their sera; of others exposed by contact, four of nine animals revealed antiviral bodies, when the intraperitoneal technique was employed. These tests on horse sera have pointed to the potential value of this procedure for epidemiological studies. Finally, the reaction itself has significance through its bearing on the mechanism of immunity.
THE PSEUDODIPHTHERIA ORGANISM IN THE URINARY TRACT
Authors: WILLIAM WARREN TOWNSEND
Journal: JAMA (1913)

The first of the following cases reported was one in which the symptoms of cystitis were most severe and resembled tuberculous cystitis. The bacteriologic examination and animal inoculation showed no tubercle bacilli, but did show the pseudodiphtheria bacillus in pure culture. Text-books on genito-urinary subjects do no more than mention the pseudodiphtheria bacillus as "an organism occasionally found in the urinary tract" and attach no importance to it pathologically. In reviewing the literature I find a case reported by Rosenow, in which the pseudodiphtheria organism was proved to be the etiologic factor. This organism is frequently associated with the gonococcus in chronic gonorrheas. I offer these facts as a reason for presenting the following case histories, summary of literature and report on the bacteriologic examination of eighty specimens of apparently normal urine. <h3>Case 1.</h3> —In January, 1911, a man, aged 21, unmarried, a farm hand, consulted me for dysuria and
Inoculation of Volunteers with H Rhinoviruses
Authors: D. Taylor-Robinson, M. L. Bynoe
Journal: BMJ (1964)

Parainfluenza Infections-Banatvala et al.MEDICBAORNAL of infection with parainfluenza viruses after a long lapse ot time.Studies over a lengthy period in Washington, D.C. (Parrott et al., 1962), have revealed that parainfluenza viruses were prevalent throughout the year.Our study agrees with Ferris (1960) and Higgins et al. (1963) in finding a seasonal distri- bution of parainfluenza infection.In Cambridge only febrile respiratory infection severe enough to require medical attention was investigated, and thus it was not possible to ascertain how much milder illness was due to parainfluenza viruses.Our survey has been carried out over a limited period of time and it is not certain that in other places similar findings will occur ; only prolonged and continuous observations of this kind can provide such information. SummaryA survey conducted from September 1962 to August 1963 in two general practices in Cambridge showed that para- influenza viruses were responsible for 18% of all acute respira- tory infections investigated.There was evidence of parainfluenza virus infection in 35 patients, most infections being due to parainfluenza 1, but a few cases of parainfluenza 2 and 3 infection also occurred.Croup was the commonest clinical manifestation in children.Infants and young children presented with the more severe ill- ness, some degree of laryngeal obstruction frequently occurring.The older children presented with a milder illness, cough and hoarse voice often being found.There were 11 cases of para- influenza infection in adults, most of whom presented clinically with an influenza-like illness.The majority of cases occurred from September 1962 to January 1963.Studies of family episodes revealed that the highest secondary attack rate occurred in the youngest age- groups, and that the serial interval between cases was in the order of five days.Viruses were isolated more easily from children than from adults, evidence of adult infection therefore being mainly sero- logical.The complement-fixation test was more efficient than the haemagglutination inhibition test in detecting significant rise in antibody titre to the parainfluenza viruses, but the best results were obtained when both tests were employed.We are indebted to a number of persons for their contributions to this study: Dr. A. P. Waterson for his help throughout the preparation of this paper ; Dr. R. B. Heath for doing the H.I. tests; to Mrs. I.
Paralysis Following Injection
Authors: David W. Alspaugh
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adenosine-Induced Vasoconstriction In Vivo
Authors: Rebecca K. Shepherd, Joel Linden, Brian R. Duling
Journal: Circulation Research (1996)

Adenosine, a vasodilator metabolite, is often produced in tissues where the demand for oxygen exceeds the supply. We have recently demonstrated in isolated cannulated arterioles that adenosine and its metabolite, inosine, can also cause vasoconstriction by stimulation of mast cells. Secondary release of histamine and thromboxane is responsible for the inosine-induced constriction in vivo. In the present study, we explored the vasomotor effects of adenosine in vivo and investigated the role of the A3 adenosine receptor in mediating vasoconstriction. In vivo, local application of adenosine (10-6 to 10-4 mol/L) to arterioles consistently caused dose-dependent vasodilation. A fraction of arterioles, however, exhibited a biphasic response, with constriction following dilation. This, too, was dose dependent; 37% of arterioles constricted by 12.7 +/- 4.3% of the initial diameter in response to 10-4 mol/L adenosine. In the presence of 8-(p-sulfophenyl)theophylline (8-SPT), an antagonist of A1 and A2 adenosine receptors, dilation in response to the same dose of adenosine was reduced, and constriction was enhanced; 85% of the tested arterioles constricted by -44.3 +/- 6.0% of the initial diameter. The A3 adenosine receptor has been shown to facilitate mediator release from mast cells, and its role was also examined. N6-(3-Iodo-4-aminobenzyl)adenosine (I-ABA), an agonist of A1 and A3 adenosine receptors, produced dose-dependent vasoconstriction. 1,3-Dipropyl-8-(4-acrylate)phenylxanthine (BW-A1433), an antagonist of A1, A2, and A3 receptors, significantly reduced the vasoconstrictor response to adenosine, which was unmasked during treatment with 8-SPT. In addition, both adenosine and I-ABA stimulated mast cell uptake of ruthenium red, indicating degranulation. The I-ABA-induced constriction was abolished by combined histamine and thromboxane receptor antagonists. We conclude that adenosine can cause vasoconstriction in vivo, which is often masked by A2 receptor-mediated vasodilation. Mast cells are stimulated in the course of the response, and the A3 adenosine receptor is involved in mediating constriction.
Transfer of Erythropoietin to Amniotic Fluid in Rh-immunized Pregnant Women
Authors: S. Halvorsen, P. H. Finne
Journal: BMJ (1963)

M URnu identical on each occasion.In the final episode the rise in plasma uric acid to levels which involved marked supersaturation of the plasma was followed by oliguric renal failure with crystallization in the renal medulla..". .ew ..00.) expected to result in a temporary improvement........ in riena Fwa. 3.-Post-mortem spemen ofkidney shpowimngtri aci ands urates. in tuue.(culzShmd.x.0.RTemvl.of a consider let ppretin of then excss uric acid from the patient by haemodialysis might be expected to result in a temporary improvement in renal function.Presumably this is the explanation of the return of normal urine output and sustained fall in plasma urea level after the second dialysis, since there was no evidence of haematological improvement at this Stage.
INFLAMMATORY DISLOCATION OF THE ATLAS
Authors: D. C. L. Fitzwilliams
Journal: BMJ (1934)

ATLAS [MTHFBRIJTL 107.particularly interesting in view of the extensive nature of the coronary and intramyocardial arterial disease.The epileptiform seizures in the advanced stage of the illness could not be associated with any detectable cerebral, arterial, or other primary intracranial disease.It is surprising, in view of the considerable renal arterial disease, that no further indication than a mild albuminuria was present, and that the blood urea was only 44 mg. per 1O() c.cm.The absence of pain in relation to the abdominal viscera is notable; possibly the absence of any arterial haemorrhages or extensive thrombosis explains this latter phenomenon. SurrmmryIt is evident from a study of the literature and the cases outlined in this paper that the clinical disorder known as rheumatic fever is essentially a disease affect- ing numerous structures in the body, but with special affinity for damaging the cardiac and arterial structures.The association suggested regarding a common aetiological agent in these cases is evident, and in the light of recent records it would appear that whereas streptococcal infec- tion or toxaemia in rheumatic fever may confine the tissue damage to certain individual structures-for example, heart valve or nervous system-in other cases a variable degree of severe arterial disease may occur and render itself apparent by any of the symptoms by which pen- arteritis nodosa is recognized.The possible grave prog- nostic importance of these latter phenomena is indicated in the cases here discussed.We are grateful to our senior physician, Dr. Mackey, for his permission to use the case records.