Warfarin Resistance and Vitamin K
Authors: Mary Lee, Roweena N. Schwartz, Roohollah Sharifi
Journal: Annals of Internal Medicine (1981)

Letters1 January 1981Warfarin Resistance and Vitamin KMARY LEE, PHARM.D., ROWEENA N. SCHWARTZ, ROOHOLLAH SHARIFI, M.D.MARY LEE, PHARM.D.Search for more papers by this author, ROWEENA N. SCHWARTZSearch for more papers by this author, ROOHOLLAH SHARIFI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-1-140_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently, cases of warfarin resistance due to unrecognized vitamin K supplementation in liquid nutrition products have been described (1, 2). These reports came coincidentally, as we were managing a patient with apparent anticoagulant resistance due to the same cause. She was a 70-year-old woman who had had pelvic exenteration for carcinoma of the proximal urethra. Over the next 3 weeks she received 3 L of crystalline amino acid solution without vitamin K supplementation, and a 14-day course of chloramphenicol for treatment ofBacteroides fragilissepticemia. During her convalescence she developed an acute episode of deep venous thrombosis...References1. O'REILLYRYTAND RD. Resistance to warfarin due to unrecognized vitamin K supplementation. N Engl J Med. 1980;303:160-1. CrossrefMedlineGoogle Scholar2. LADERYOUNGCLARKE ELA. Warfarin dosage and vitamin K in osmolite. Ann Intern Med. 1980;93:373-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARY LEE, PHARM.D.; ROWEENA N. SCHWARTZ; ROOHOLLAH SHARIFI, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCoumarin anticoagulantsVitamin and mineral supplementsDrug–Nutrient Interactions in Patients Receiving Enteral NutritionANTICOAGULANTS, THROMBOLYTIC AGENTS, AND ANTI-PLATELET DRUGSWarfarin resistance and enteral tube feeding: A vitamin K–independent interactionPharmacodynamic resistance to warfarin is associated with nucleotide substitutions inVKORC1Warfarin Resistance and Enteral Tube Feeding: An Old Problem with a New SolutionVitamin K–Independent Warfarin Resistance After Concurrent Administration of Warfarin and Continuous Enteral NutritionCoumarin anticoagulantsDrug-Nutrient Interactions in Patients Receiving Enteral NutritionMedication Administration Considerations for Patients Receiving Enteral Tube FeedingsVitamin K: A Practical Guide to the Dietary Management of Patients on WarfarinVitamin K: A Practical Guide to the Dietary Management of Patients on WarfarinInteraction of Dietary Factors with Oral AnticoagulantsHigh clearance of (S)-warfarin in a warfarin-resistant subject.ThrombosisWarfarin Resistance and Enteral FeedingsNutrients as Supplements, Drugs, and NostrumsASPECTS OF ANTICOAGULANT ACTION: A Review of the Pharmacology, Metabolism and Toxicology of Warfarin and CongenersWarfarin resistance linked to enteral nutrition productsFamilial Warfarin ResistanceDrugs affecting blood clotting, fibrinolysis and hemostasis 1 January 1981Volume 94, Issue 1Page: 140-141KeywordsAmino acidsAnticoagulantsBacteroidesChloramphenicolConvalescenceDeep vein thrombosisNutritionSepsisVitamin K ePublished: 1 December 2008 Issue Published: 1 January 1981 PDF downloadLoading ...