tbuckley/cabot-search huggingface dataset:
Abstract 5440: Klf2 Inhibits Hif-1{alpha} Expression and Function in the Endothelium
Authors: Daiji Kawanami, Zhiyong Lin, Ganapati Mahabaleshwar, G. B Atkins, Anne Hamik, Saptarsi Haldar, Koji Maemura, Jerry Lingrel, Mukesh Jain
Journal: Circulation (2008)

Introduction: Hypoxia-inducible factor 1 (HIF-1) is a central regulator of the hypoxic response in many cell types. In endothelial cells, HIF-1 induces the expression of key pro-angiogenic factors such as vascular endothelial growth factor (VEGF) to induce new blood vessel formation. Recent studies have identified Kruppel-like Factor 2 (KLF2) as a potent inhibitor of angiogenesis. However, the role of KLF2 in regulating the expression and function of HIF-1 has not been evaluated. Hypothesis: KLF2 inhibits HIF-1α expression and function. Methods and Results: Adenoviral overexpression of KLF2 in human umbilical vein endothelial cells (HUVECs) inhibited hypoxia-induced expression of HIF-1α, VEGF secretion, and matrigel tube formation. Conversely, siRNA-mediated knockdown of KLF2 in HUVECs increased HIF-1α expression and VEGF secretion. Consistent with this observation, KLF2−/− mouse embryonic fibroblasts (MEFs) showed accelerated HIF-1α accumulation in response to hypoxia and a marked induction of VEGF secre...
INTRATRACHEAL ANESTHETIC MACHINE
Authors: A. W. ADSON
Journal: JAMA (1918)

statistics here reported are in accord with the com¬ parable figures for such of these materials as Sherman and Forbes have analyzed.The high calcium content of the green vegetables in contrast with that of the tubers and roots is very striking.There may be a loss of inorganic constituents, par¬ ticularly calcium, in the cooking of foods and in the preparation of some of them for drying.
Thrombin receptor expression in normal and atherosclerotic human arteries.
Authors: N A Nelken, S J Soifer, J O'Keefe, T K Vu, I F Charo, S R Coughlin
Journal: Journal of Clinical Investigation (1992)

Thrombin is a multifunctional serine protease generated at sites of vascular injury. A host of thrombin actions on vascular endothelial cells, smooth muscle cells, and macrophages has been defined in cell culture systems, but the in vivo significance of these activities is unknown. We have defined the expression of the recently identified receptor for thrombin in human arteries by both in situ hybridization and immunohistochemistry. In normal-appearing arteries, thrombin receptor was expressed almost exclusively in the endothelial layer. By contrast, in human atheroma, the receptor was widely expressed, both in regions rich in macrophages and in regions rich in vascular smooth muscle cells and mesenchymal-appearing intimal cells of unknown origin. Thrombin receptor was expressed by human vascular endothelial cells and smooth muscle cells in culture and by macrophages obtained by bronchioalveolar lavage, thus demonstrating that all three cell types are indeed capable of expressing the thrombin receptor. These results establish thrombin receptor activation as a candidate for contributing to sclerotic and inflammatory processes in the human vasculature, such as those that occur in atherosclerosis and restenosis.
Prevalence of hepatitis B virus infection among black children in Soweto.
Authors: A M Dibisceglie, M C Kew, G M Dusheiko, E L Berger, E Song, A C Paterson, H J Hodkinson
Journal: BMJ (1986)

Roughly 15% of black children in rural areas of southern Africa are carriers of the hepatitis B virus. The purpose of the present study was to determine the prevalence of chronic hepatitis B virus infection among urban black children born and growing up in Soweto. A total of 2364 children were studied, ranging in age from 3 to 19 years, and of these, 1319 (56%) were girls. The children were drawn from the highest and the lowest socioeconomic classes. Serum samples were tested for all hepatitis B virus markers as well as IgG antibody against hepatitis A virus. HBsAg was detected in 23 (0.97%) of the children, anti-HBc and anti-HBs together in 155 (6.6%), anti-HBc alone in 17 (0.7%), and anti-HBs alone in 72 (3%). Of the 2364 children, 2097 (88.5%) were negative for all hepatitis B virus markers. IgG antibody to hepatitis A virus was present in 175 (97%) of a sample of 179 children. There was no difference in prevalence of hepatitis B virus markers between children from the upper and lower socioeconomic classes. HBsAg was more common in boys (16 out of 1043 (1.5%) than girls (seven out of 1321 (0.57%), and the prevalence of all hepatitis B virus markers increased with age. The youngest carrier of hepatitis B virus was 7 years old. The remarkable difference in the hepatitis B virus carrier rate between urban and rural black children offers a unique opportunity to investigate the favourable influences operating in an urban environment to limit the prevalence of hepatitis B virus infection.
Equivalence of Generic and Brand-Name Drugs for Cardiovascular Disease
Authors: Michael James Zema
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Graduated Patient Responsibility-Reply
Authors: William J. Grace
Journal: JAMA (1975)

<h3>In Reply.—</h3> Dr. Coodley's remarks on the COMMENTARY, "Graduated Patient Responsibility," appear to balance permissiveness against dependence, resentment, and even indignation. We have not experienced such response to graduate responsibility in many years of teaching. Instead, members of the house staff, well aware of defects in training and experience, welcome rather than resent the help and advice of their seniors. Certainly, Dr. Coodley would not hold that there is an equality of knowledge at all levels of training, nor would he deny that all of us can learn. The fear of legal action is admittedly a minor consideration in a teaching program, but here in New York as in many states it is not an absurdity but a threatening reality compounded by many insurers withdrawing from the malpractice field. Perhaps this threat does not haunt the practice of psychiatry or psychoanalysis as it does the practice of internal medicine and
Notes on the Quarterly Return of Births, Deaths, and Marriages
Authors: E. T. Wilson
Journal: BMJ (1870)

s College, London, and I, published cases of syphilitic disorders of the brain and its membranes respectively, in 1851 and i852, the subject has attained a high degree of practical value and nosological importance.The cases we at that time submitted were in direct contravention of the universally accepted opinion and authority which ruled sturgeons.It is within the roll of the maladies usually assigned to the care of the physician, that we now trace and follow out the most serious and even fatal results of constitutional syphilis.In my own paper, first series (Dzbliz Quarterly .ournal,I852), I have unequivocally proved that epilepsy, mania, hemiplegia, paraplegia, amaurosis, hebetude of intellect, loss of memory, cranial neuralgia, suicidal propensity, paralysis of sphincters-all may be the offspring of the one disturbing cause-syphilis affecting the nervous centres.How this protracted darkness overshadowed the observations and judgment of generations of eminent medical men, I can in no way account for, unless in this way: the surgeon bad dismissed his patient on the disappearance of all local and visible disorder.Authority had guaranteed the brain exempt from all syphilitic forces.The subsequent injuries of the nervous system were intrusted to the recognised speciality of the physician, whose nosological nomenclature of the nervous system gave no place in its roll, no clue to a true diagnosis, until recent times sup- plied the defect.With this prelude, I propose to submit a statement referring to this subject
Abstract 1827: Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells
Authors: Justine R. Stehn, Nikolas K. Haass, Melissa Desouza, Gregg Kottyan, Herbert Treutlein, Jun Zeng, Paula R. Nascimento, Min Hi Han, Timothy A. Hill, Adam McCluskey, Stephen Palmer, Edna C. Hardeman, Wolfgang Weninger, Timothy P. Cripe, Peter Gunning
Journal: Cancer Research (2012)

Abstract The actin cytoskeleton is an important regulator of a variety of cellular functions making it an ideal chemotherapeutic target. Despite this promise no anti-actin compounds are used in current chemotherapy, primarily due to the inability of existing anti-actin agents to discriminate between the actin cytoskeleton of tumor cells and that of the muscle sarcomere. We have previously shown that tropomyosin, an integral component of the actin cytoskeleton, defines functionally distinct actin filament populations. We have designed a new class of compounds which target a specific cancer associated tropomyosin isoform, Tm5NM1. Anti-tropomyosin (Tm) compounds were selected based on ability to target the actin cytoskeleton and efficacy against a panel of neuroblastoma and melanoma cell lines. The lead compound, TR100, was shown to be effective against a panel of tumor cell lines (average EC50 3µM). Preliminary studies demonstrate that TR100 induces cell death via the intrinsic (mitochondrial) apoptotic pathway and the mechanism appears to be independent of the pro apoptotic factors BAX and BAK. In 3D melanoma spheroid models, which more accurately mimic the tumor microenvironment, TR100 inhibited cell growth and motility. This translated to a reduction in tumor cell growth in neuroblastoma and melanoma xenograft models. Analysis of drug treated animals showed no evidence of cardiac damage as measured by blood Troponin I levels and the intraventricular septum thickness of isolated hearts. These results demonstrate the possibility of targeting distinct actin filament populations based on tropomyosin composition. Next generation anti-Tm compounds with improved efficacy and specificity have now been developed. Preliminary data demonstrate that these compounds exhibit increased selectivity for transformed cells. Taken together, our findings suggest that the anti-Tm compounds show a significant improvement in the therapeutic window compared to existing anti-actin agents. This novel approach and the development of the new class of anti-Tm compounds may be the key for disabling a long sought after target, the actin cytoskeleton, and may lead to a new class of chemotherapeutics active against a broad range of cancer types. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1827. doi:1538-7445.AM2012-1827
Young Academic Physicians and Publication-Reply
Authors: Victor C. Strasburger
Journal: JAMA (1986)

<h3>In Reply.—</h3> I am grateful to Dr Lecklitner for his kind remarks and am extremely sympathetic to his concerns about the plight of young physicians interested in academic careers. My wife is one of them! However, he seems to imply that I advocate an end to all medical publishing by younger physicians. That would put a number of people out of business (including myself) and would inhibit the "rapid dissemination of new ideas" so necessary for medicine to progress and flourish. What I was suggesting was something different: young academics should not be "forced" to publish when (1) they may not be interested in publishing papers, (2) they may not be able to write publishable papers, or (3) they may have nothing publishable to say. If alternative routes to tenure are available, eg, service, teaching, or patient care, then publishing may be selected<i>voluntarily</i>. Perhaps only then will the quality
THE BOSTON SESSION OF THE COLLEGE
Authors: GLENVILLE GIDDINGS
Journal: Annals of Internal Medicine (1941)

College News Notes1 June 1941THE BOSTON SESSION OF THE COLLEGEGLENVILLE GIDDINGS, M.D., F.A.C.P.GLENVILLE GIDDINGS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-12-2321 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe 25th Annual Session of the College, held in Boston, April 21-25, 1941, produced the largest gross attendance of any Meeting in the College history—although the New York Session in 1938 produced the largest member attendance. Physicians were present from forty-six states and the District of Columbia (Nevada and New Mexico were not represented), from Puerto Rico, from seven provinces of Canada, from Panama, China, Cuba, Mexico, and from Chile and Colombia of South America. The following is a comparative summary of the registration for the past four years:It was observed that those states which hold regional meetings produced... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1941Volume 14, Issue 12Page: 2321-2345 ePublished: 1 December 2008 Issue Published: 1 June 1941 PDF downloadLoading ...
Abstract 2734: c-Met antibody LY2875358 (LA480) shows differential antitumor effects in non-small cell lung cancer
Authors: Wei Zeng, Lei Yan, Victoria Peek, Mark Wortinger, Jonathan Tetreault, Jinqi Xia, Chi-Kin Chow, Jason R. Manro, Jennifer R. Stephens, Spring N. Weir, Ying Tang, Peter Vaillancourt, Jirong Lu, Betty S. Yan, Ling Liu
Journal: Cancer Research (2012)

Abstract c-Met is a member of the receptor tyrosine kinase family and is the receptor for hepatocyte growth factor (HGF). c-Met is involved in many mechanisms of cancer proliferation and metastasis. Inappropriate activation of c-Met can be induced by ligand-independent mechanisms such as gene amplification, specific genetic mutations, and transcriptional up-regulation, or by ligand-dependent autocrine or paracrine mechanisms. Lung cancer is the leading cause of cancer death worldwide. Despite the successful development of EGFR- or EML4-ALK-targetd therapies, treatment options remain limited for patients with advanced lung cancer, making the identification of new therapeutic targets essential. c-Met expression was reported in 41-72% non-small cell lung cancer (NSCLC), amplification of c-Met occurs in 5-10 % of patients, and c-Met mutations have been detected in 8-13% of patients. We have developed a bi-valent c-Met antibody LY2875358 (LA480), which blocks ligand-dependent and ligand-independent c-Met activations. It is currently in clinical development. Here, we have demonstrated that LY2875358 alone or in combination with standard-of-care (SOC) affected cell proliferation, migration and signal transduction in NSCLC cells with c-Met gene amplification, mutations and overexpression. In vitro, LY2875358 induces wild type and mutant c-Met internalization and degradation. In vivo, LY2875358 alone shows a marked antitumor activity in Met amplification NSCLC xenograft models. The combination of LY2875358 with SOC chemotherapeutics treatments has better efficacy than either treatment alone, both in vitro and in vivo. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2734. doi:1538-7445.AM2012-2734
Problematic Consequences of Using Standard Errors Rather Than Standard Deviations—Reply
Authors: Robert G. Santos, Anita Durksen, Jonathan M. McGavock
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Improvement of treadmill capacity and collateral circulation as a result of exercise with heparin pretreatment in patients with effort angina.
Authors: M Fujita, S Sasayama, H Asanoi, H Nakajima, O Sakai, A Ohno
Journal: Circulation (1988)

It has been demonstrated in animal experiments that heparin accelerates the coronary collateral development induced by repeated coronary occlusion. We used this effect of heparin for the treatment of patients with stable effort angina. In 10 patients, treadmill exercise was performed according to standard Bruce protocol twice a day for 10 days. A single intravenous dose of heparin (5000 IU) was given 10 to 20 min before each exercise period. Exercise with heparin pretreatment increased the total exercise duration from 6.3 +/- 1.9 (SD) to 9.1 +/- 2.2 min (p less than .001) and the maximal double product (DP) from 18,900 +/- 5100 to 25,500 +/- 6800 mm Hg.beats/min (p less than .001). The DP at the onset of angina was also increased by 35% (p less than .01) and the DP at which ST depression (0.1 mV) first appeared was 19% (p less than .05) greater after treatment. Repeat coronary cineangiography revealed an increase in the extent of opacification of collaterals to the jeopardized myocardium. In an additional six patients, treadmill exercise was performed with no medication twice a day for 10 days. All of the above-mentioned variables of treadmill capacity remained unchanged, despite 20 exercise periods without heparin pretreatment. Thus, heparin accelerates exercise-induced coronary collateral development by promoting angiogenesis. The development of such a therapeutic modality will open a new field for the treatment of patients with ischemia.
Smokeless Tobacco and Oral Cancer: A Cause for Concern?
Authors: C. A. Squier
Journal: CA A Cancer Journal for Clinicians (1984)

Until recently, the use of smokeless tobacco had been restricted to a relatively small percentage of the United States population. The increased promotion and use of both snuff and chewing tobacco raise the question: What effect will such habits have on oral disease and the incidence of oral cancer? Although information for the US is sparse, extensive epidemiologic data are available from India, where the use of tobacco is prevalent and the incidence of oral cancer very high. The Indian data suggest that (1) oral cancer and precancerous lesions occur almost solely among those with tobacco habits, (2) the rate of malignant transformation of precancerous lesions is not greater than in the West,(3) the relative risk of developing oral cancer is similar in India and in the US, and (4) this risk rises with duration of use. Thus, it seems likely that increased usage of smokeless tobacco in the US will eventually lead to an increased incidence of Precancerous and cancerous oral lesions in Americans.
If I can do it anyone can
Authors: K. Harris
Journal: BMJ (1997)

Certainly for me, the key to a fulfilling old age is staying independent. Though I'm 82 on the surface, I feel about 50 inside. I feel mature enough to know how difficult life has been, but young enough to start doing new things.

By nature I am very independent, and still do my own housework except cleaning the windows, as my children have persuaded me that climbing isn't such a good idea. My doctor doesn't understand this attitude, and offers all sorts of help, which I don't need. My response is to say that when I do need it, I will ask, and then I will expect it to be available.

Old age is a time of great opportunity. A positive mental attitude is more important than being strong physically, and perhaps it's something you're born with or learn at a young age. I know people who say that they would love to do something new, but they can't. If someone says I …
Immunogenetics recognized by Nobel Prize
Authors: Elizabeth Rasche González
Journal: JAMA (1980)

George Snell, DSc, Jean Dausset, MD, and Baruj Benacerraf, MD: These names, heretofore little known outside scientific circles, have in recent weeks become familiar to millions of people. Born early this century in Massachusetts, France, and Venezuela, respectively, these three elder statesmen (aged 76, 63, and 60 years, respectively) of histocompatibility research will be in Stockholm Dec 6 to accept their joint Nobel Prize in Medicine. The Royal Caroline Institute of Medicine notes that the prize—$211,000, to be split among the three scientists—is being awarded for elucidation of the histocompatibility gene complex, which controls most immunologic reactions. Knowledge of that complex, which specifies antigens on the cell surface, has had profound implications for the understanding of phenomena ranging from the rejection of kidney and bone marrow transplants to the pathogenesis of autoimmune disorders. Snell's contribution, which led the way for histocompatibility antigen matching in transplantation, was his discovery of the
Cincinnati, April 24, 1906.
Authors: E. S McKee
Journal: JAMA (1906)

<h3>To the Editor:</h3> —The letter of Dr. Fletcher Ingals inThe Journalmeets with my hearty approval. There certainly should be a spirit of fraternity among physicians both at home and abroad, and especially so among members of the American Medical Association. I am surprised that the button is not more worn at other times than at the annual sessions.