tbuckley/cabot-search huggingface dataset:
SUBCLINICAL ABNORMALITIES OF LEFT VENTRICULAR MYOCARDIAL DEFORMATION IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND NORMAL LEFT VENTRICULAR EJECTION FRACTION
Authors: Samir Sulemane, Vasileios F. Panoulas, Athanasios Bratsas, Andrew Frankel, Edwina Brown, Petros Nihoyannopoulos
Journal: Journal of the American College of Cardiology (2013)
NOTE ON A CASE OF KELOIDS FOLLOWING SMALLPOX
Authors: J. M. H. MACLEOD, E. H. T. CUMMINGS
Journal: British Journal of Dermatology (1936)

Journal Article NOTE ON A CASE OF KELOIDS FOLLOWING SMALLPOX Get access J. M. H. MACLEOD, M.D., F.R.C.P., J. M. H. MACLEOD, M.D., F.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar E. H. T. CUMMINGS, M.D. E. H. T. CUMMINGS, M.D. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 48, Issue 5, 1 May 1936, Pages 245–247, https://doi.org/10.1111/j.1365-2133.1936.tb10335.x Published: 01 May 1936
ROENTGEN FINDINGS IN THE PNEUMONIAS FOLLOWING INFLUENZA
Authors: Harry F. Friedman
Journal: JAMA (1918)

<h3>To the Editor:</h3> —The roentgen examination of the chests of influenza patients during the recent epidemic revealed some very interesting conditions. The cases were not selected to any great extent. The diagnosis of pneumonia, as a rule, was made clinically, and the roentgen ray was used only as corroborative evidence and to determine the extent of involvement. The striking feature was the apparent difference in opinion as to the type, whether lobar pneumonia or bronchopneumonia. When seen early, the patients presented a rather marked peribronchial infiltration of the larger trunks, with a local or general mediastinitis. The lung structure appeared normal and the movements of the diaphragm were unimpaired. This pathologic condition either became stationary with a corresponding improvement in the clinical symptoms or there was a rapid progression out into the lung structure with the development, as a rule, of a bronchopneumonia. In a few instances, the pneumonia was
CHARACTERISTIC CHANGES IN BLOOD CHEMISTRY IN WHOOPING COUGH
Authors: JOSEPH C. REGAN
Journal: JAMA (1926)

Whooping cough still remains a source of a far from negligible mortality and of a great morbidity in childhood. A disease that causes 10,000 deaths in one year in the United States is certainly a serious menace. Yet this does not take into consideration the mortality indirectly attributable to it from predisposition to other infections, notably tuberculosis, nor does it take into account the morbidity resulting from it due to the persistent alterations induced so often in the bronchopulmonary tract; nor, indeed, can any calculation be made that would adequately express the detrimental effect on the nutritional status of the patient, a condition that probably persists often for a prolonged period of time. In the study of pertussis there has not, it appears, been as much attention given to the chemical analysis of the composition of the blood as it would seem is merited by the importance of this aspect
Spraying lawns and eating grass
Authors: G. Dunea
Journal: BMJ (2002)

Again and again we turn to the daily papers for news and inspiration. We learn that Americans are living longer than ever (mean of 74 years for men, 80 for women); 61% are overweight; infant mortality is at a low of 6.9 per 1000 live births; healthcare costs continue to rise; and a panel recommends that people should exercise at least one hour a day. They should also stay away from mosquitoes, …
Endoscopic Therapy of the Sump Syndrome
Authors: A. Polydorou, J. F. Dowsett, D. Vaira, P. R. Salmon, P. B. Cotton, R. C. G. Russell
Journal: Endoscopy (1989)

Seventeen consecutive patients with the sump syndrome were treated at the Middlesex Hospital between November 1983 and December 1987. Fifteen were treated primarily by endoscopic sphincterotomy and two primarily by resective surgery because of coincident severe painful chronic pancreatitis. Endoscopic sump clearance was successful in thirteen out of fifteen cases (87%) with no morbidity or mortality. The two endoscopic failures were managed surgically. Follow-up (mean 18 months; range 2-48 months) has shown complete resolution of symptoms in twelve (71%), with mild or moderate ongoing symptoms in the remaining five. All patients with ongoing symptoms after sump clearance had abnormal retrograde pancreatograms at the time of ERCP. Endoscopic sphincterotomy is the treatment of choice for the sump syndrome, with the possible exception of patients with coincident painful severe chronic pancreatitis, who may require pancreatic resection. Indeed, the sump may be a factor in the development and perpetuation of an obstructive chronic pancreatitis, and a trial of endoscopic clearance may be indicated even in these patients. The sump syndrome should no longer be regarded as a major long-term disadvantage of side-to-side biliary bypass, provided that the condition is considered early in those with compatible symptoms after biliary bypass, and appropriate investigation and treatment is instigated.
Lymphoma in cotton-top marmosets after inoculation with Epstein-Barr virus: tumor incidence, histologic spectrum antibody responses, demonstration of viral DNA, and characterization of viruses.
Authors: G Miller, T Shope, D Coope, L Waters, J Pagano, G Bornkamn, W Henle
Journal: The Journal of Experimental Medicine (1977)

6 of 20 cotton-top tamarins (Saguinus oedipus) inoculated with Epstein-Barr virus (EBV) developed diffuse malignant lymphoma resembling reticulum cell or immunoblastic sarcoma of man. Hyperplastic lymphoreticular lesions were induced in three additional animals; in two instances the hyperplastic lesions regressed. Inapparent infection with development of antibody occured in eight animals. In two animals there was no evidence of EBV infection. One animal died in the first week after inoculation of parasitic infection. 10 animals uninoculated or mock-inoculated developed neither lymphoproliferative disease nor antibody. The malignant lymphoma appeared to arise from a cell with an uncleaved vesicular nucleus found in the center of the germinal follicle. The prominent cytologic features of this cell were extensive formation or rough endoplasmic reticulum and elaboration of the cytoplasmic membrane with microvilli. Cell lines derived from these tumors did not have receptors for complement. IgFc, or sheep erythrocytes, and the cell lines adhered to glass and plastic. EB nuclear antigen was found in imprints of two lymph nodes, one with lymphoma and one with hyperplasia. EB virus DNA was detected directly in the tumors of three animals and in cell lines from two lymphomas. Typical herpes virus particles were found in supernatant fluids from cell lines obtained from lymph nodes with tumors and hyperplasia, as well as in lines derived from blood leukocytes of marmosets with inapparent infection. These virus preparations had the biologic property characteristic of EBV, namely, stimulation of cellular DNA synthesis and immortalization of human lymphocytes. The virus derived from two cell lines was neutralized by reference human sera with EBV antibody and not by antibody-negative human sera. The virus derived from the experimental lesions is thus indistinghishable from human EBV. The marmoset has enhanced susceptibility to oncogenesis by EB virus. Among identified factors which may play a role in the heightened tumorigenicity of EB virus in this species are the increased production of virus by transformed cells and the absence of membrane receptors for complement or IgFc on transformed cells.
Efficient Cell Reprogramming Using Bioengineered Surfaces
Authors: David Horna, Juan Carlos Ramírez, Anna Cifuentes, Antonio Bernad, Salvador Borrós, Manuel A. González
Journal: Advanced Healthcare Materials (2012)

A novel method for cell reprogramming is been developed by immobilizing nucleic acid transfer vectors containing free amino groups, like lentiviral particles, onto pentafluorophenyl methacrylate (PFM)-modified surfaces obtained by PFM grafting affter Ar plasma treatment. This technique is able to reprogram murine somatic cells into pluripotent cells at high efficiencies. We call these modified surfaces cell reprogramming surfaces, or CRS.
Tranylcypromine: Effects on Norepinephrine Metabolism in Rat Brain
Authors: JOSEPH J. SCHILDKRAUT
Journal: American Journal of Psychiatry (1970)

This investigation examines the effects of tranylcypromine on the uptake, release, and metabolism of intracisternally administered tritiated norepinephrine (norepinephrine-H3) in rat brain. The findings suggest that, in addition to being a potent inhibitor of the enzyme monoamine oxidase, tranylcypromine discharges norepinephrine extraneuronally onto receptors and possibly also inhibits the neuronal reuptake of this amine. These neuropharmacological effects of tranylcypromine may possibly account for the greater clinical efficacy of tranylcypromine in the treatment of some depressed patients and the higher incidence of hypertensive cerebrovascular reactions when this drug is compared with other monoamine oxidase inhibitors.
t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma
Authors: Sandrine Roulland, Rachel S. Kelly, Ester Morgado, Stéphanie Sungalee, Philippe Solal-Celigny, Philippe Colombat, Nathalie Jouve, Domenico Palli, Valeria Pala, Rosario Tumino, Salvatore Panico, Carlotta Sacerdote, José R. Quirós, Carlos A. Gonzáles, Maria-José Sánchez, Miren Dorronsoro, Carmen Navarro, Aurelio Barricarte, Anne Tjønneland, Anja Olsen, Kim Overvad, Federico Canzian, Rudolf Kaaks, Heiner Boeing, Dagmar Drogan, Alexandra Nieters, Françoise Clavel-Chapelon, Antonia Trichopoulou, Dimitrios Trichopoulos, Pagona Lagiou, H. Bas Bueno-de-Mesquita, Petra H.M. Peeters, Roel Vermeulen, Göran Hallmans, Beatrice Melin, Signe Borgquist, Joyce Carlson, Eiliv Lund, Elisabete Weiderpass, Kay-Tee Khaw, Nick Wareham, Timothy J. Key, Ruth C. Travis, Pietro Ferrari, Isabelle Romieu, Elio Riboli, Gilles Salles, Paolo Vineis, Bertrand Nadel
Journal: Journal of Clinical Oncology (2014)

Purpose The (14;18) translocation constitutes both a genetic hallmark and critical early event in the natural history of follicular lymphoma (FL). However, t(14;18) is also detectable in the blood of otherwise healthy persons, and its relationship with progression to disease remains unclear. Here we sought to determine whether t(14;18)-positive cells in healthy individuals represent tumor precursors and whether their detection could be used as an early predictor for FL. Participants and Methods Among 520,000 healthy participants enrolled onto the EPIC (European Prospective Investigation Into Cancer and Nutrition) cohort, we identified 100 who developed FL 2 to 161 months after enrollment. Prediagnostic blood from these and 218 controls were screened for t(14;18) using sensitive polymerase chain reaction–based assays. Results were subsequently validated in an independent cohort (65 case participants; 128 controls). Clonal relationships between t(14;18) cells and FL were also assessed by molecular backtracking of paired prediagnostic blood and tumor samples. Results Clonal analysis of t(14;18) junctions in paired prediagnostic blood versus tumor samples demonstrated that progression to FL occurred from t(14;18)-positive committed precursors. Furthermore, healthy participants at enrollment who developed FL up to 15 years later showed a markedly higher t(14;18) prevalence and frequency than controls (P &lt; .001). Altogether, we estimated a 23-fold higher risk of subsequent FL in blood samples associated with a frequency &gt; 10 −4 (odds ratio, 23.17; 95% CI, 9.98 to 67.31; P &lt; .001). Remarkably, risk estimates remained high and significant up to 15 years before diagnosis. Conclusion High t(14;18) frequency in blood from healthy individuals defines the first predictive biomarker for FL, effective years before diagnosis.
Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man
Authors: Anthony D. Jose, Roger R. Taylor
Journal: Journal of Clinical Investigation (1969)

Blockade of cardiac autonomic nervous activity by an intravenous injection of 0.2 mg/kg propranolol and 0.04 mg/kg atropine was used with cardiac catheterization to study intrinsic cardiac function in 47 patients with normal hearts and known graded myocardial disease. After blockade, significant hemodynamic abnormalities became apparent at rest in the majority of patients with known disease, many of whom had normal control findings. This occurred partly through a reduction in the normal range of cardiac function at rest, and partly through changes in the abnormalities associated with disease: after blockade, diseased hearts had normal stroke volumes, but beat more slowly, and had higher left ventricular filling pressures. The heart rate after blockade was fixed; this was defined as the intrinsic heart rate (IHR); it ranged from 57 to 126 beats/min in different patients. Both the IHR and left ventricular end-diastolic pressure after blockade were sensitively and quantitatively related to the severity of myocardial disease. When, after blockade, arterial pressure was raised by angiotensin, the IHR was unchanged; normal hearts maintained their stroke volume and increased stroke work; diseased hearts maintained stroke volume less well and stroke work was unchanged or fell. Abnormal ventricular responses corresponded well with abnormal ventricular function at rest. In different patients the IHR was significantly related to each available index of left ventricular function. Other studies in animals have shown that the IHR is closely related to intrinsic myocardial contractility in certain forms of experimental heart failure. An analogous relationship existing between the IHR and myocardial function in patients with heart disease is suggested as the explanation for the IHR/ventricular function relationship in this study. If so, the IHR may prove valuable as an index of myocardial function in man, since it can be measured simply and safely in clinical practice.
Nine UK doctors are suspended after accusations of viewing child pornography
Authors: C. Dyer
Journal: BMJ (2003)

Nine doctors in the United Kingdom have been suspended by their NHS trusts after accusations that they downloaded pornographic pictures of children from the internet.

The nine have also been suspended from practice by the interim orders committee of the General Medical Council, pending hearings into allegations of serious professional misconduct. Suspensions pending hearings are deemed necessary in a minority of cases to protect the public.

The doctors came to the attention of the police as part of Operation Ore, a massive, nationwide operation against child pornography. Police are investigating 6500 internet addresses passed to them by the Federal …
AT-11 * FINAL RESULTS FROM THE RANDOMIZED PHASE II TRIAL AVAREG (ML25739) WITH BEVACIZUMAB (BEV) OR FOTEMUSTINE (FTM) IN RECURRENT GBM
Authors: A. A. Brandes, G. Finocchiaro, V. Zagonel, M. Reni, A. Fabi, C. Caserta, M. Clavarezza, E. Maiello, G. Carteni, G. Rosti, M. Eoli, G. Lombardi, M. Monteforte, R. Agati, V. Eusebi, A. Galli, S. Doria, E. Franceschi
Journal: Neuro-Oncology (2014)

AIM: The treatment of recurrent glioblastoma remains an open issue and the role of BEV has been largely debated since only few data compared this agent with the standard agents. METHODS: A multicenter, open-label, randomized (2:1), non-comparative phase II study (EudraCT:2011-001363-46; AVAREG-ML25739) with BEV 10 mg/m2 iv every 2 weeks or FTM 75 mg/m2 iv day 1-8-15 followed, after a 35 days interval, by FTM 100 mg/m2 every 3 weeks, was conducted. Primary endpoint was overall survival at 6 months (OS6). RESULTS: 91 pts with recurrent GBM were enrolled among 10 Italian centers between 11/2011 and 9/2012. Median age was 57 years (range:28-78), PS was 0/1/2 in 42/35/14 pts. All pts were treated with RT/TMZ accordingly with EORTC 26981-22981/NCIC-CE3. Time from diagnosis to 1st recurrence was 331 days in the BEV arm and 460 days in the FTM arm. At time of recurrence, 21 pts (23.1%) received re-resection before the study inclusion (13/8 pts in BEV/FTM arms). Fifty-nine pts were enrolled in the BEV arm and 32 pts in the FTM arm. OS6 was 62.1% (95%CI:48.4-74.5) and 73.3% (95%CI:54.1-87.7), OS9 was 37.9% (95%CI:25.5-51.6) and 46.7% (95%CI:28.3-65.7) in the BEV and FTM arms, respectively. Median OS was 7.3 months (95%CI:5.8-9.2) in the BEV arm and 8.7 months (95%CI:6.3-15.4) in the FTM arm. PFS6 was 26.3% and 10.7%, respectively. In the BEV arm, OS6 and OS9 were 77.8% (95%CI:57.7-91.4) and 59.3% (95%CI:38.8-77.6) in pts =55 yrs, and were 48.4% (95%CI:30.1-66.9) and 19.3% (95%CI:7.4-37.5) in pts >55 yrs. HR for OS in BEV group for pts >55 yrs compared with pts =55 yrs was 2.0 (95%CI:1.0-4.1, p = 0.05). G3-4 toxicity: thrombocytopenia 0% vs 21.9%, neutropenia 1.7% vs 12.5%, intestinal perforation and cerebral ischaemia/hemorrhage 3.4% vs 0%, pulmonary thromboembolism 1.7% vs 0%, and acute myocardial infarction 1.7% vs 0%, in the Bev and FTM arms respectively. CONCLUSIONS: BEV in recurrent GBM showed survival rates superimposable with FTM.
Abstract LB-314: Patients with inflammatory breast cancer have significant reductions in immune cells responsible for adaptive immunity
Authors: Bang-Ning Lee, Hui Gao, Evan N. Cohen, Eleni Andreopoulou, Summer A. Jackson, Charla Parker, Sanda Tin, Matthew Galland, Naoto Ueno, Vicente Valero, Ricardo H. Alvarez, Massimo Cristofanilli, James M. Reuben
Journal: Cancer Research (2010)

Abstract Background: Cell-mediated immunity is essential for maintaining immune surveillance against tumor progression. Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer, yet there is a paucity of information on peripheral blood leukocyte immunophenotypes of these patients. Therefore, we enumerated the immune cells of IBC patients with or without metastasis. Methods: This ongoing prospective study consists of 43 IBC patients, 22 with non-metastatic IBC and 21 with metastatic disease (MIBC). Peripheral blood was collected prior to starting a new therapy and analyzed to determine the immunophenotype of T cells, B cells, regulatory T (TR) cells, natural killer cells (NK), and dendritic cells (DC) by 6-color flow cytometry. The Kruskal-Wallis and Mann-Whitney U tests were used to determine the differences between healthy donors (HD, N=15), non-metastatic IBC and MIBC patients. Results: Among the 43 IBC patients, 22 are hormonal receptor (HR)+ with 11 HER-2+, 8 are HR- but HER2+, and 13 are triple receptor negative. Non-metastatic IBC patients have significantly lower median percentages (%) of lymphocytes (P=0.018), B cells (P=0.028), and myeloid DC (P=0.049), and higher median % TR cells (P=0.039) when compared with those of HD. In addition, non-metastatic IBC patients have significantly lower median counts of B cells (P=0.003), myeloid DC (P=0.009), and plasmacytoid DC (P=0.037) when compared with those of HD. Moreover, compared with non-metastatic IBC patients, MIBC patients were significantly older (P=0.029) and have significantly lower median % and absolute counts of lymphocyte and B cells (all P&amp;lt;0.02), lower median ratio of CD4+/CD8+ T cells (P=0.028), and lower median number of TR cells (P=0.013). Conclusion: This preliminary cross-sectional analysis suggests that non-metastatic IBC patients have significant reductions in various effector cells, in particular, B-cells and antigen-presenting DC that may lead to compromised adaptive immunity. Moreover, metastatic IBC patients are more immunocompromised than non-metastatic IBC patients. Longitudinal study is warranted to further assess the role of humoral and cell-mediated immunity in the pathogenesis of IBC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-314.
T cell and non-T cell compartments can independently determine resistance to Leishmania major.
Authors: A H Shankar, R G Titus
Journal: The Journal of Experimental Medicine (1995)

In experimental murine cutaneous leishmaniasis caused by Leishmania major (Lm), the cellular determinants governing development of protective or exacerbative T cells are not well understood. We, therefore, attempted to determine the influence of T cell and non-T cell compartments on disease outcome. To this end, T cell chimeric mice were constructed using adult thymectomized lethally irradiated, bone marrow-reconstituted (ATXBM) animals of genetically resistant, C57BL/6, or susceptible, BALB/c, backgrounds. These hosts were engrafted with naive T cell populations from H-2-congenic susceptible, BALB.B6-H-2b, or resistant, C57BL/6.C-H-2d, animals, respectively. Chimeric mice were then infected with Lm, and disease outcome was monitored. BALB/c T cell chimeric mice, BALB/c ATXBM hosts given naive C57BL/6.C-H-2d T cells, resolved their infections as indicated by reductions in both lesion size and parasite numbers. Furthermore, the mice developed typical Th1 (interferon[IFN]-gamma hiinterleukin[IL]-4lo) cytokine patterns. In contrast, both sham chimeric, BALB/c ATXBM hosts given naive BALB/c T cells, and control irradiated euthymic mice succumbed to infection, producing Th2 profiles (IFN-gamma loIL-4hiIL-10hi). C57BL/6 T cell chimeras, C57BL/6 ATXBM hosts given naive BALB.B6-H-2b T cells, resolved their infections as did C57BL/6 sham chimeras and euthymic controls. Interestingly, whereas C57BL/6 control animals produced Th1 cytokines, chimeric animals progressed from Th0 (IFN-gamma hiIL-4hiIL-10hi) to Th2 (IFN-gamma loIL-4hiIL-10hi) cytokine profiles as cure ensued. Both reconstitution and chimeric status of all mice were confirmed by flow cytometry. In addition, T cell receptor V beta usage of Lm-specific blasts was determined. In all cases, V beta use was multiclonal, involving primarily V beta 2, 4, 6, 8.1, 8.2, 8.3, 10, and 14, with relative V beta frequencies differing between H-2b and H-2d animals. Most importantly, however, these differences did not segregate between cure and noncure outcomes. These findings indicate that: (a) genetic traits determining cure in Lm infection can direct disease outcome from both T cell and non-T cell compartments; (b) the presence of the curing genotype in only one compartment is sufficient to confer cure; (c) curing genotype T cells autonomously assume a Th1 cytokine profile-mediating cure; (d) noncuring genotype T cells can mediate cure in a curing environment, despite the onset of Th2 cytokine production; and lastly, (e) antigen specificity of responding T cells, as assessed by V beta T cell receptor diversity, is not a critical determinant of disease outcome.
THE USE OF METHEDRINE IN THE DIAGNOSIS AND TREATMENT OF THE PSYCHONEUROSES
Authors: T. M. LING, L. S. DAVIES
Journal: American Journal of Psychiatry (1952)

From this study of 140 cases, it is concluded that d-N- Methylamphetamine Hydrochloride or methedrine, when used in psychoneurotic illnesses, particularly in chronic anxiety states, neurodermatitis, and the acute posttraumatic anxieties, produces an emotionally free-flow material that may include painful memories of traumatic experiences, and that will provide the patient with permanent relief. In the majority of cases, the responses evoked are helpful, both diagnostically and therapeutically.
A PHASE I/IIA FIRST IN MAN SAFETY AND TOLERABILITY STUDY OF A NOVEL HNO DONOR, CXL-1020, IN PATIENTS WITH STABLE CONGESTIVE HEART FAILURE
Authors: Doug Cowart, Juan Aranda, Garrie Haas, Joel Neutel, William Smith, Reza Mazhari, Vince Kalish, Wilson Colucci
Journal: Journal of the American College of Cardiology (2011)