STREPTOMYCIN IN THE TREATMENT OF TUBERCULOSIS IN HUMANS
Authors: WALSH MCDERMOTT
Journal: Annals of Internal Medicine (1947)

Article1 November 1947STREPTOMYCIN IN THE TREATMENT OF TUBERCULOSIS IN HUMANSI. MENINGITIS AND GENERALIZED HEMATOGENOUS TUBERCULOSIS*WALSH MCDERMOTT, CARL MUSCHENHEIM, F.A.C.P., SUSAN J. HADLEY, PAUL A. BUNN, ROSEMARY V. GORMANWALSH MCDERMOTT, CARL MUSCHENHEIM, F.A.C.P., SUSAN J. HADLEY, PAUL A. BUNN, ROSEMARY V. GORMANAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-5-769 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONShortly after the first report on streptomycin by Waksman and his associates,1Feldman and Hinshaw observed that the drug exerted a pronounced effect upon the course of tuberculous infections in guinea pigs.2On the basis of these findings, a clinical investigation was started, and in September 1945 Hinshaw and Feldman reported that streptomycin exerted a suppressive effect upon the course of various forms of tuberculous infections in humans.3Although the therapeutic claims of these investigators were notably restrained in this and their subsequent reports,4, 5it was apparent that the alterations in the course of tuberculous infections observed by...Bibliography1. SCHATZBUGIEWAKSMAN AESA: Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria, Proc. Soc. Exper. Biol. and Med., 1944, lv, 66-69. CrossrefGoogle Scholar2. FELDMANHINSHAW WHHC: Effects of streptomycin on experimental tuberculosis in guinea pigs: A preliminary report, Proc. Staff Meet., Mayo Clinic, 1944, xix, 593-599. Google Scholar3. HINSHAWFELDMAN HCWH: Streptomycin in treatment of clinical tuberculosis: A preliminary report, Proc. Staff Meet., Mayo Clinic, 1945, xx, 313-318. Google Scholar4. HINSHAWFELDMANPFEUTZE HCWHKH: Treatment of tuberculosis with streptomycin, Jr. Am. Med. Assoc., 1946, cxxxii, 778-782. CrossrefGoogle Scholar5. HINSHAWPYLEFELDMAN HCMMWH: Streptomycin in tuberculosis, Am. Jr. Med., 1947, ii, 429-435. CrossrefGoogle Scholar6. MUSCHENHEIMMCDERMOTTHADLEYHULL-SMITHTRACY CWSJHA: Streptomycin in the treatment of tuberculosis in humans. II. Pulmonary tuberculosis, Ann. Int. Med. (To be published.) Google Scholar7. FARRINGTONHULL-SMITHBUNNMCDERMOTT RFHPAW: Streptomycin toxicity: Reactions to highly purified drug on long continued administration to human subjects, Jr. Am. Med. Assoc., 1947, cxxxiv, 679-688. CrossrefGoogle Scholar8. FRIEDTITUS JE: Streptomycin B, an antibiotically active constituent of streptomycin concentrates, Jr. Biol. Chem., 1947, clxviii, 391-392. CrossrefGoogle Scholar9. HOBBYLENERT GTF: Biological activity of a residual form of streptomycin against Eberthella typhosa , Proc. Soc. Exper. Biol. and Med., 1947, lxv, 249-254. CrossrefGoogle Scholar10. MCDERMOTT W: Toxicity of streptomycin, Am. Jr. Med., 1947, ii, 491-500. CrossrefGoogle Scholar11. DUBOSDAVIS RJBD: Factors affecting the growth of tubercle bacilli in liquid media, Jr. Exper. Med., 1946, lxxxiii, 409-423. CrossrefGoogle Scholar12. STEBBINSROBINSON RBHJ: A method for determination of streptomycin in body fluids, Proc. Soc. Exper. Biol. and Med., 1945, lix, 255. CrossrefGoogle Scholar13. BOXERJELINEKLEGHORN GEVCPM: The colorimetric determination of streptomycin in clinical preparations, urine, and brain, Jr. Biol. Chem., 1947, clxix, 153. CrossrefGoogle Scholar14. STEVENSONALVORDCORRELL LDECJW: Degeneration and necrosis of neurones in eighth cranial nuclei caused by streptomycin, Proc. Soc. Exper. Biol. and Med., 1947, lxv, 86-88. CrossrefGoogle Scholar15. : Diagnostic Standards and Classifications of Tuberculosis, 1940, New York. Google Scholar16. FLOREYKIDDMCDERMOTTMUSCHENHEIM CJWC: To be published. Google Scholar17. KARLSONFELDMAN AGWH: Resistance of tubercle bacilli to streptomycin in guinea pigs after administration of the drug: The effect on response to treatment with streptomycin, Abstr. Proc. Soc. Am. Bacteriologists, Philadelphia, May 1947, pg. 67. Google Scholar18. YOUMANSWILLISTON GPEH: Effect of streptomycin on experimental infections produced in mice with streptomycin resistant strains of M. tuberculosis var. hominis , Proc. Soc. Exper. Biol. and Med., 1946, lxiii, 131-134. CrossrefGoogle Scholar19. STEENKENWOLINSKY WE: Personal communication. Google Scholar20. FISHER MW: Personal communication. Google Scholar21. SELBIE FR: Microbial resistance to chemotherapeutic drugs, Brit. Med. Bull., 1946, iv, 267. CrossrefGoogle Scholar22. MILLERBOHNHOFF CPM: Observations on the development of streptomycin resistance by meningococcus. Presented at Conference on Antibiotic Research held at Washington, D. C., on January 31 and February 1, 1947, under the auspices of the Antibiotics Study Section, National Institute of Health. Google Scholar23. HALLSPINK WHWW: In vitro sensitivity of brucella to streptomycin: Development of resistance during streptomycin treatment, Proc. Soc. Exper. Biol. and Med., 1947, lxiv, 403-406. CrossrefGoogle Scholar24. RICH AR: The pathogenesis of tuberculosis, 1944, Charles C. Thomas, Springfield, Illinois. CrossrefGoogle Scholar25. MIDDLEBROOKYEGIAN GD: Certain effects of streptomycin on mycobacteria in vitro, Am. Rev. Tuberc., 1946, liv, 553-558. Google Scholar26. YOUMANS GP: A method for the determination of the culture cycle on the growth rate of virulent human type tubercle bacilli, Jr. Bacteriol., 1946, li, 703-710. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Portions of this study were presented before the annual meetings of: the American College of Physicians, April 29, 1947; the American Society for Clinical Investigation, May 5, 1947; and the Section on Internal Medicine of the American Medical Association, June 12, 1947.From the Department of Medicine of the New York Hospital-Cornell University Medical College.The first part of this investigation was conducted under the direction of the National Research Council Committee on Chemotherapeutics and Other Agents, Dr. Chester S. Keefer, Chairman. The subsequent investigation is a part of the Streptomycin Manufacturers-American Trudeau Society program which is being conducted in collaboration with the Tuberculosis Study Section of the National Institute of Health. The streptomycin was furnished by the Chemotherapeutic Committee; by a generous donation from Charles Pfizer and Company, Inc., Brooklyn; and from supplies donated to the American Trudeau Society by the Streptomycin Manufacturers.The study was aided in part by grants from the National Institute of Health, and from the Lederle Laboratories, Inc., Pearl River, New York. 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HADLEY, HARRIET HULL-SMITH, ALICE TRACY 1 November 1947Volume 27, Issue 5Page: 769-822KeywordsChemotherapeutic agentsDrugsRiversStreptococcal infectionsStreptomycin Issue Published: 1 November 1947 PDF DownloadLoading ...