tbuckley/cabot-search huggingface dataset:
Sinus Standstill Following Lidocaine Administration
Authors: Dante Antonelli
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Lidocaine hydrochloride is used widely in the suppression of ventricular arrhythmias, especially during acute myocardial infarction (AMI). At the conventional therapeutic loading dose of 1 mg/kg of body weight, it is generally safe and has no inhibitory effect on sinus-node activity.<sup>1</sup>In this report, we describe a case of sinus standstill following administration of a bolus of intravenous lidocaine, given in the conventional dose. <h3>Report of a Case.—</h3> A 65-year-old woman was admitted to our intensive coronary care unit (ICCU) with AMI of the diaphragmatic wall. At first examination, body weight was 51 kg; BP, 100/60 mm Hg; and heart rate, 108 beats per minute. At auscultation, a 2/6 systolic murmur was heard in the mitral area, and diffuse crepitations in the pulmonary area were heard; the ECG showed sinus rhythm, incomplete left bundle-branch block, ST-segment elevation in II-III-aV<sub>L</sub>leads and negative T waves in aV
Vesical Calculi and Hyperparathyroidism
Authors: Philip A. Yalowitz
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The overwhelming majority of vesical calculi in the United States are associated with obstructive or neurologic diseases of the lower urinary tract. Although these conditions are the commonly accepted causes of bladder stones,<sup>1</sup>occasionally hyperparathyroidism is an associated etiologic factor. The first such case was reported by Albright and associates<sup>2</sup>in 1934 in one of the original descriptive articles of hyperparathyroidism. Nine cases have been reported altogether.<sup>3, 4</sup>In all the presence of a commonly accepted cause for vesical calculi other than hyperparathyroidism was recognized but in three instances the bladder stones were the only manifestation of calculous disease of the urinary tract. We have recently encountered another case of vesical calculi and hyperparathyroidism in a patient who also had prostatic obstruction. This case is reported to emphasize the occasional association of bladder stones and parathyroid adenomas. <h3>Report of a Case:—</h3> A 67-year-old man
Five Loci, <i>SLT1</i> to <i>SLT5</i>, Controlling the Susceptibility to Spontaneously Occurring Lung Cancer in Mice
Authors: Daolong Wang, Ming You
Journal: Cancer Research (2005)

Abstract A series of linkage studies was previously conducted to identify quantitative trait loci associated with chemically induced lung tumors. However, little is known of genetic susceptibility to spontaneously occurring lung tumorigenesis (SLT) in mice. In this study, we did a whole-genome linkage disequilibrium analysis for susceptibility to SLT in mice using ∼135,900 single-nucleotide polymorphisms (SNPs) from the Roche and Genomic Institute of the Novartis Research Foundation SNP databases. A common set of 13 mouse strains was used, including 10 resistant strains (129X1/SvJ, AKR/J, C3H/HeJ, C57BL/6J, DBA/2J, NZB/BlnJ, CAST/EiJ, SPRET/EiJ, SM/J, and LP/J) and 3 susceptible strains (A/J, BALB/cJ, and NZW/LaCJ). Fisher exact test was used to assess the association between individual SNPs and susceptibility to SLT. Five regions, SLT1 to SLT5, were mapped on chromosomes 6, 7, 8, 19, and X, respectively. SLT1 to SLT5 showed a significant association with SLT under the empirical threshold (P ≤ 0.004) derived from permutation tests. SNP versus SNP association tests indicated that these SLT regions were unlikely to be caused by population substructure. Thus, SLT1 to SLT5 seem to be novel loci controlling the susceptibility to spontaneously occurring lung cancer in mice. Our results provide, for the first time, an insight into the genetic control of spontaneously occurring lung tumorigenesis.
Recurrent Colon Cancer Involving the Urinary Bladder Identified With F-18 FDG PET/CT After Forced Diuresis
Authors: Chao-Jung Chen, Tung-Bo Chao, Deng-Fuh Shih
Journal: Clinical Nuclear Medicine (2010)

We present the case of a 66-year-old man with a history of synchronous transverse and sigmoid colon cancer, who had undergone surgery 11 months before a follow-up scan. F-18 FDG PET/CT at that time showed no other abnormality. His serum carcinoembryonic antigen (CEA) level returned to normal after surgery. An elevated serum CEA level during the follow-up and F-18 FDG PET/CT showed a solitary hypermetabolic nodule on the patient's urinary bladder. Owing to the intense urinary radioactivity, the nodule was difficult to visualize on the early image but was easily seen on the delayed image after forced diuresis. His bladder tumor was surgically excised; it tested positive for adenocarcinoma, consistent with the colon tumor.
Complement-dependent histaminase release from human granulocytes.
Authors: J J Herman, I K Rosner, A E Davis, R S Zeiger, M A Arnaout, H R Colten
Journal: Journal of Clinical Investigation (1979)

The role of particle-bound complement proteins in the induction of noncytotoxic enzyme release from human granulocytes was investigated with the use of sera genetically deficient in complement and highly purified complement components. Release of histaminase, one of two important histamine catabolizing enzymes, and beta-glucuronidase from polymorphonuclear leukocytes was solely dependent on particle-bound C3b (the larger cleavage product of the third component of complement) when fluid-phase complement was excluded. The extent of enzyme release was a function of particle-bound C3b input, was reduced by exposing the particles to C3b inactivator, and was blocked by fluid-phase C3b. Phagocytosis of the C3b-coated particles was not required for enzyme release from neutrophils. In contrast, phagocytosis of "opsonized" particles was required for noncytotoxic release of histaminase and arylsulfatase from eosinophils; other proteins, as well as C3b, were able to opsonize particles for induction of enzyme release from eosinophils. These studies suggest a dual role for complement (particularly C3) in modulating vascular permeability phenomena, i.e., release of vasoactive mediators by the action of C3a and C5a, and release of the corresponding enzymes that inactivate the mediators by C3b.
The Role of T-Cell Costimulatory Activation Pathways in Transplant Rejection
Authors: Mohamed H. Sayegh, Laurence A. Turka
Journal: New England Journal of Medicine (1998)

Organ transplantation is now common. For patients with end-stage cardiac, hepatic, or pulmonary failure, it can be lifesaving.1 For patients with diabetes mellitus, pancreatic transplantation offers the chance of a cure and the arrest or reversal of diabetic complications such as neuropathy and retinopathy. In 1996 more than 19,410 organ and tissue transplantations were performed in the United States, and 53,755 patients were on waiting lists for transplantation.Over the past two decades, the development of new immunosuppressive drugs with improved efficacy and decreased toxicity has led to substantial improvement in the survival of patients and in short-term graft survival . . .
Population-Based Biomonitoring of Exposure to Organophosphate and Pyrethroid Pesticides in New York City
Authors: Wendy McKelvey, J. Bryan Jacobson, Daniel Kass, Dana Boyd Barr, Mark Davis, Antonia M. Calafat, Kenneth M. Aldous
Journal: Environmental Health Perspectives (2013)

Organophosphates and pyrethroids are the most common classes of insecticides used in the United States. Widespread use of these compounds to control building infestations in New York City (NYC) may have caused higher exposure than in less-urban settings.The objectives of our study were to estimate pesticide exposure reference values for NYC and identify demographic and behavioral characteristics that predict exposures.The NYC Health and Nutrition Examination Survey was a population-based, cross-sectional study conducted in 2004 among adults ≥ 20 years of age. It measured urinary concentrations of organophosphate metabolites [dimethylphosphate (DMP), dimethylthiophosphate (DMTP), dimethyldithiophosphate, diethylphosphate, diethylthiophosphate, and diethyldithiophosphate] in 883 participants, and pyrethroid metabolites [3-phenoxybenzoic acid (3-PBA), trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (trans-DCCA), 4-fluoro-3-phenoxybenzoic acid, and cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid] in 1,452 participants. We used multivariable linear regression to estimate least-squares geometric mean total dialkylphospate (ΣDAP) and 3-PBA concentrations across categories of predictors.The dimethyl organophosphate metabolites had the highest 95th percentile concentrations (87.4 μg/L and 74.7 μg/L for DMP and DMTP, respectively). The highest 95th percentiles among pyrethroid metabolites were measured for 3-PBA and trans-DCCA (5.23 μg/L and 5.94 μg/L, respectively). Concentrations of ΣDAP increased with increasing age, non-Hispanic white or black compared with Hispanic race/ethnicity, professional pesticide use, and increasing frequency of fruit consumption; they decreased with non-green vegetable consumption. Absolute differences in geometric mean urinary 3-PBA concentrations across categories of predictors were too small to be meaningful.Estimates of exposure to pyrethroids and dimethyl organophosphates were higher in NYC than in the United States overall, underscoring the importance of considering pest and pesticide burdens in cities when formulating pesticide use regulations.
Secretory Immunoglobulin A and Analgesic-Associated Diseases
Authors: Olof Forssman, Svend-Aage Johnsen, Barbro Carlsson
Journal: Annals of Internal Medicine (1981)

Letters1 January 1981Secretory Immunoglobulin A and Analgesic-Associated DiseasesOLOF FORSSMAN, M.D., SVEND-AAGE JOHNSEN, M.D., BARBRO CARLSSON, M.D.OLOF FORSSMAN, M.D.Search for more papers by this author, SVEND-AAGE JOHNSEN, M.D.Search for more papers by this author, BARBRO CARLSSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-1-140_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Gonwa and associates (1) does not consider the possible mechanisms by which some patients with analgesic-associated nephropathy develop a cell carcinoma of the urinary tract. Because disorders with immunodeficiency have an higher incidence of malignancies than expected and phenacetin may exert an influence on the local immune defense, we studied the excretion of secretory IgA in fresh urinary specimens of three patients with analgesic-associated nephropathy, and tumor, using an ELISA method (2). The values obtained were within the normal limits, although the patient with the most advanced nephropathy had a value just at...References1. GONWACORBETTSCHEYBUCKALEW TWHV. Analgesic-associated nephropathy and transitional cell carcinoma of the urinary tract. Ann Intern Med. 1980;93:249-52. LinkGoogle Scholar2. AKERLUNDHANSSONAHLSTEDTCARLSSON SLSB. A sensitive method for specific quantitation of secretory IgA. Scand J Immunol. 1977;6:1275-82. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: East Hospital Department of Immunology Gothenburg Sweden PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1981Volume 94, Issue 1Page: 140-140KeywordsEnzyme linked immunosorbent assayExcretionImmunodeficienciesUrinary tract infections Issue Published: 1 January 1981 PDF DownloadLoading ...
Metastatic Melanocarcinoma Involving the Small Intestine and Brain
Authors: Jack Spier, Edwin C. Wood
Journal: New England Journal of Medicine (1947)

REVIEWING the recent literature concerning diseases of the small bowel, one is impressed with the infrequency of reports of malignant tumors. Narrowing the field of interest to melanomas occurring in the small bowel certainly increases the task of locating appropriate material in many cases. With these points in view this paper is directed toward a broad comparative survey of the occurrence of malignant lesions in the small intestine, with special emphasis on melanomas.In about 10 per cent of cases at autopsy a carcinoma is found somewhere in the body. A review of 137,174 cases gathered from various hospitals by . . .
Trigeminal Neuralgia at Exceptionally Early Age
Authors: W. Harris
Journal: BMJ (1943)

ConclusionNothing perhaps requires greater emphasis in this paper than that all these points concerning technique should be thoroughly understood by the nursing staff.Some of them may seem trivial, but it is only by constant attention to these details that this method of continuous intravenous drip transfusion will consistently give the good results which are justly claimed for it.
Foundation calls for universal hepatitis B vaccination in UK infants
Authors: Lynn Eaton
Journal: BMJ (2004)

The UK government should meet demands from the World Health Organization and introduce universal vaccination against hepatitis B for infants, says the Foundation for Liver Research.

At the moment, the United Kingdom only targets high risk groups for vaccination, such as healthcare workers, men who have sex with men, sex workers, and injecting drug users. Babies of infected mothers are also vaccinated.

The foundation's latest report also calls for better diagnosis and treatment of the disease. Hepatitis B: Out of the Shadows cites Department of Health figures, which estimate that there are currently 180 000 people with chronic hepatitis B in the United Kingdom. Every year a further 7700 people become …
Identification of a <i>Cyclin D1</i> Network in Prostate Cancer That Antagonizes Epithelial–Mesenchymal Restraint
Authors: Xiaoming Ju, Mathew C. Casimiro, Michael Gormley, Hui Meng, Xuanmao Jiao, Sanjay Katiyar, Marco Crosariol, Ke Chen, Min Wang, Andrew A. Quong, Michael P. Lisanti, Adam Ertel, Richard G. Pestell
Journal: Cancer Research (2013)

Abstract Improved clinical management of prostate cancer has been impeded by an inadequate understanding of molecular genetic elements governing tumor progression. Gene signatures have provided improved prognostic indicators of human prostate cancer. The TGF-β/BMP-SMAD4 signaling pathway, which induces epithelial–mesenchymal transition (EMT), is known to constrain prostate cancer progression induced by Pten deletion. Herein, cyclin D1 inactivation reduced cellular proliferation in the murine prostate in vivo and in isogenic oncogene–transformed prostate cancer cell lines. The in vivo cyclin D1–mediated molecular signature predicted poor outcome of recurrence-free survival for patients with prostate cancer (K-means HR, 3.75, P = 0.02) and demonstrated that endogenous cyclin D1 restrains TGF-β, Snail, Twist, and Goosecoid signaling. Endogenous cyclin D1 enhanced Wnt and ES cell gene expression and expanded a prostate stem cell population. In chromatin immunoprecipitation sequencing, cyclin D1 occupied genes governing stem cell expansion and induced their transcription. The coordination of EMT restraining and stem cell expanding gene expression by cyclin D1 in the prostate may contribute to its strong prognostic value for poor outcome in biochemical-free recurrence in human prostate cancer. Cancer Res; 74(2); 508–19. ©2013 AACR.
Acute glomerulonephritis in middle-aged and elderly patients.
Authors: H. A. Lee, G. Stirling, P. Sharpstone
Journal: BMJ (1966)

Acute glomerulonephritis is an uncommon disease in the middle-aged and elderly. Of the 173 cases investigated by Ellis (1942) only three were over 50 and none was over 60 ; and Fishberg (1954) reported only once seeing a patient older than 60. While acute glomerulonephritis may pursue a malignant course?with death from oliguric renal failure in the acute phase, at any age?older patients seem particularly prone to this severe variant of the disease. Further, in this age group the presenting features often differ from those commonly seen in younger patients (Samiy, Field, and Merrill, 1961). It is for these reasons that we report the clinical and pathological features of the seven patients aged over 50 seen at the renal unit of King's College Hospital in a three-year period from 1962 to 1965. They were all referred from other hospitals because of renal failure severe enough to warrant consideration of haemodialysis. During this time no younger patient with this disease required haemodialysis at this unit.
Effect of endogenous and inhaled nitric oxide on the ventilation-perfusion relationships in oleic-acid lung injury.
Authors: C Putensen, J Räsänen, J B Downs
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Previous investigations have shown that the ventilation-perfusion (VA/Q) mismatch caused by acute lung injury can be alleviated either by inducing vasodilation in ventilated lung units with inhaled nitric oxide (NO) or by inhibiting the synthesis of endogenous NO, which opposes hypoxic pulmonary vasoconstriction. To determine the effects of a combination of these interventions, we evaluated cardiopulmonary function and VA/Q distributions in 10 dogs with oleic acid-induced lung injury. Each animal received, in random order, zero or 40 ppm of NO in inspiratory gas, with and without intravenous infusion of NG-monomethyl-L-arginine (L-NMMA) (5 mg/kg/h). The multiple inert-gas elimination technique was used to estimate VA/Q distributions. Systemic L-NMMA administration alone did not affect VA/Q inequality and gas exchange, but increased pulmonary and systemic vascular resistance. Inhaled NO improved gas exchange by redistributing blood flow from shunt units to lung units with a nearly ideal VA/Q ratio, without affecting pulmonary or systemic vascular resistance. Improved VA/Q matching and gas exchange was most pronounced when NO was inhaled in the presence of systemic L-NMMA. Inhalation of NO reversed the pulmonary but not the systemic vasoconstriction caused by L-NMMA. These results suggest that endogenous NO release is not limited to hypoxic lung regions in animals with oleic acid-induced lung injury. Inhaled NO reversed L-NMMA-induced pulmonary vasoconstriction and improved VA/Q matching by selectively dilating the pulmonary vasculature in ventilated lung units.
Abstract B29: GILZ mediates glucocorticoid action and inhibits hypoxia-induced COX-2 expression in A549 cells
Authors: WonChung Lim, YoungJoo Lee
Journal: Cancer Research (2015)

Abstract The COX-2/PGE2 pathway in hypoxic cancer cells has important implications for stimulation of inflammation and tumourigenesis. Glucocorticoid receptor (GR) strongly suppresses COX-2 expression induced by inflammatory stimuli. However, the role of GR pathway on COX-2 induction by hypoxia and the mechanisms involved are not known. We examined whether the hypoxia induction of COX-2 was under the influence of glucocorticoid; we found that COX-2 promoter activity and mRNA and protein levels were depressed by dexamethasone and antagonized by the glucocorticoid receptor (GR) antagonist RU486. Overexpression of glucocorticoid-induced leucine zipper (GILZ) inhibited hypoxia-induced COX-2 promoter activity, and knockdown of GILZ by shRNA reduced glucocorticoid inhibition of hypoxia-induced COX-2 expression. Finally, we show that dexamethasone and GILZ inhibits cell invasion by hypoxia in A549 cells. Our results suggest that GR inhibits the hypoxic induction of COX-2 expression via GILZ and regulates cell invasion under hypoxia in A549 cells. Citation Format: WonChung Lim, YoungJoo Lee. GILZ mediates glucocorticoid action and inhibits hypoxia-induced COX-2 expression in A549 cells. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr B29. doi:10.1158/1538-7445.CHTME14-B29
257 LACK OF GP130/STAT IN HEPATOCYTES LEADS TO THE EMERGENCE OF OVAL CELLS AND EXTENSIVE LIVER FIBROSIS IN A MODEL OF CHRONIC CHOLESTATIC LIVER INJURY
Authors: W. Plum, E. Corsten, U. Dierssen, S. Erschfeld, D. Tschaharganeh, C. Trautwein, K. Streetz
Journal: Journal of Hepatology (2008)
Infectious Gastroenteritis with the Acquired Immunodeficiency Syndrome (AIDS)
Authors: J.M. Miró
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 August 1988Infectious Gastroenteritis with the Acquired Immunodeficiency Syndrome (AIDS)J.M. Miró, MD, J. Mallolas, MD, A. Moreno, MD, J.M. Gatell, MD, M.E. Valls, MDJ.M. Miró, MDSearch for more papers by this author, J. Mallolas, MDSearch for more papers by this author, A. Moreno, MDSearch for more papers by this author, J.M. Gatell, MDSearch for more papers by this author, M.E. Valls, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-4-342 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Diarrhea is very common in patients infected with human immunodeficiency virus (HIV) (1, 2). There are few studies, however, of the incidence of infectious gastroenteritis in patients with the acquired immunodeficiency syndrome (AIDS). Recently, Smith and colleagues (3) have described the cause and the clinical characteristics of gastroenteritis in homosexual men with AIDS in the United States. In other areas, such as Spain, where parenteral drug addicts are the most important risk group for AIDS, the incidence and cause of infectious gastroenteritis in patients with AIDS will most likely be different (4).Since 1984, we have identified...References1. GelbMiller AS. AIDS and gastroenterology. Am J Gastroenterol. 1986;81:619-22. MedlineGoogle Scholar2. MathewsonDupont JH. Diarrhea in patients with acquired imunodeficiency syndrome. Infect Dis Newsletter. 1987;6:61-2. CrossrefGoogle Scholar3. SmithLaneGillManischewitzQuinnanFauciMasur PCVJGAH. Intestinal infections with the acquired immunodeficiency syndrome (AIDS). Etiology and response to therapy. Ann Intern Med. 1988;108:328-33. LinkGoogle Scholar4. RosFueyoLlachMorenoLatorre EJJAX. Isospora belli infection in patients with AIDS in Catalunya, Spain. N Engl J Med. 1987;317:246-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital Clinic i Provincial Villarroel, 170, 08036- Barcelona Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiarrhea in patients infected with the human immunodeficiency virus 15 August 1988Volume 109, Issue 4Page: 342-342KeywordsAIDSAddictsDiarrheaGastroenteritisHIVHIV-1Homosexuals Issue Published: 15 August 1988 PDF downloadLoading ...
Ensuring Access to Health Care
Authors: George W. Bush
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal