tbuckley/cabot-search huggingface dataset:
Macroeconomics and health
Authors: R. H Morrow
Journal: BMJ (2002)

Macroeconomics and Health, a provocative report from the World Health

M acroeconomics and Health, a provocative report from the World Health Organization, is a dramatic call for action from both rich countries and poor countries.1 The report emphasises the linkage of avoidable disease to poverty and argues that investmentsin health are fundamental to and perhaps a prerequisite for economic development. The report proposes a massive increase in funding for health in the poor countries, with a fivefold increase in support from wealthy countries and at least a doubling from the poor countries themselves.

The key recommendation is for the world's poor countries to work in partnership with high income countries to scale up their health systems to provide access for all to a limited number of essential health interventions. Although emphasising the partnership of the poor with the rich, the report is primarily an advocacy document addressed to the donor nations. It requests the high income countries to resolve “that lack of donor funds should not be the …
Application of Automated Multiphasic Health Testing in Clinical Medicine
Authors: Henry F. Howe
Journal: JAMA (1972)

Automated multiphasic health testing offers prospects of exciting new adjuncts to conventional techniques for health maintenance or diagnosis in various patient populations. Such testing systems are still in their research phase, although already in operation in some medical practices and hospitals. They are in no sense a substitute for periodic medical examinations, but do present opportunities for improvement of preventive health monitoring in general and specialty medicine. They still present many problems and need adaptation to particular uses. Some of these problems are presented in this article together with some suggested guidelines in the choice of systems, the pitfalls to be overcome, and the desirability of flexibility in planning.
TCT-619 Single Bolus Regadenoson Injection Versus Central Venous Infusion Of Adenosine To Induce Maximum Coronary Hyperemia For Measurement Of FFR
Authors: Lokien X van Nunen, Guy Lenders, Stéphanie Schampaert, Marcel van't Veer, Inge Wijnbergen, Pim A. Tonino, Nico Pijls
Journal: Journal of the American College of Cardiology (2013)
Glass Bottle Workers Exposed to Low-Dose Irritant Fumes Cough but Do Not Wheeze
Authors: STEPHEN B. GORDON, ANDREW D. CURRAN, ANDREW TURLEY, CHI-HUNG WONG, SHAKIL N. RAHMAN, KEITH WILEY, ALYN H. MORICE
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Workers exposed to irritant fumes experience symptoms both during the acute episode and afterwards. High-dose irritant exposure can result in permanent asthma, but the effects of chronic low-dose irritant exposure are not known. Glass bottle workers are exposed to irritant fumes, and have previously been reported to have an excess of symptoms. We designed a study to compare irritant-exposed glass bottle workers with hospital workers matched for socioeconomic group, area of residence, age, sex, smoking habit, and allergic history. Symptoms reported, spirometry, flow cytometric indices of lymphocyte activation, and past medical and employment histories were compared. We also investigated the prevalence of bronchial hyperresponsiveness to inhaled methacholine and the cough response after inhalation of citric acid and capsaicin. Glass bottle workers showed an excess of upper respiratory tract symptoms, cough, and shortness of breath compared with matched hospital control workers. There was a significant excess of cough induced by citric acid and capsaicin in the bottle workers. However, wheeze, baseline spirometry, flow cytometry, and methacholine challenge were not significantly different between the two groups. These findings suggest that chronic irritant exposure produces an excess of symptoms and increased cough sensitivity but not asthma.
Prevalence of Urinary Incontinence among Spanish Older People Living at Home
Authors: Javier Dami&aacute;n, Jos&eacute; M. Mart&iacute;n-Moreno, F&eacute;lix Lobo, Jaime Bonache, Julio Cervi&ntilde;o, Luis Redondo-M&aacute;rquez, Eduardo Mart&iacute;nez-Agull&oacute;
Journal: European Urology (1998)
Response to Letter Regarding Article, “Monitoring of Monocyte Recruitment in Reperfused Myocardial Infarction With Intramyocardial Hemorrhage and Microvascular Obstruction By Combined Fluorine 19 and Proton Cardiac Magnetic Resonance Imaging”
Authors: Yu-Xiang Ye, Thomas C. Basse-Lüsebrink, Paula-Anahi Arias-Loza, Vladimir Kocoski, Thomas Kampf, Qiang Gan, Elisabeth Bauer, Stefanie Sparka, Xavier Helluy, Kai Hu, Karl-Heinz Hiller, Valerie Boivin-Jahns, Peter M. Jakob, Roland Jahns, Wolfgang R. Bauer
Journal: Circulation (2014)
α1-ANTTTRYPSIN-RELATED GENE (ATR) FOR PRENATAL DIAGNOSIS
Authors: C.M. Abbott, C.J. Mcmahon, G.D. Kelsey, M. Parkr, D.B. Whitehouse, G. Corney, S. Povey, D.A. Hopkinson, G. Mieli-Vergani, A. Mowat
Journal: The Lancet (1987)
Fatal Pseudomembranous Colitis Associated with a Variant <i>Clostridium difficile</i> Strain Not Detected by Toxin A Immunoassay
Authors: Stuart Johnson, Sara A. Kent, Kevin J. O'Leary, Michelle M. Merrigan, Susan P. Sambol, Lance R. Peterson, Dale N. Gerding
Journal: Annals of Internal Medicine (2001)

Background: Many clinical laboratories use toxin A immunoassays to test for Clostridium difficile. Objective: To describe the clinical course of a patient infected with a toxin variant strain of C. difficile that was not detected by toxin A immunoassay; to genetically characterize this strain; and to estimate the number of laboratories that use only toxin A immunoassays. Design: Case report, molecular investigation, and laboratory survey. Setting: Tertiary care hospital in Chicago, Illinois. Patient: An 86-year-old man. Measurements: Restriction endonuclease analysis, polymerase chain reaction, and survey of regional clinical laboratories. Results: An elderly hospitalized man died of advanced pseudomembranous colitis. Four stool specimens submitted over a 2-month period had tested negative on toxin A immunoassay, but a strain of C. difficile with a 1.8-kb deletion of the toxin A gene was recovered from each specimen. This strain, identified as restriction endonuclease analysis type CF4, is closely related to a widely disseminated variant, toxinotype VIII. Toxin A immunoassay was the only test being performed for detection of C. difficile at 31 of 67 (46%) regional clinical laboratories. Conclusions: Toxin A variant strains of C. difficile cause serious disease and are undetectable in clinical laboratories that use only toxin A immunoassays for C. difficile testing.
Aortic Regurgitation — Bounding Carotids
Authors: Carlos Valencia Calderón, Juana Barthe Carrera
Journal: New England Journal of Medicine (2005)

A 66-year-old man with a medical history notable only for locally treated prostate cancer presented with a two-month history of dyspnea on moderate exertion and repeated episodes of angina with mild effort or at rest. He came to the emergency room with exertional dyspnea that had worsened during the preceding week. There were no features of Marfan's syndrome. The blood pressure was 164/49 mm Hg (with a pulse pressure of 120 mm Hg), the radial pulses were bounding (Corrigan's pulse), and the carotid pulses were prominent (Video Clip). Cardiac examination revealed decreased S1 and increased S2 intensity, with a grade . . .
The Semmelweis House— A Memorial Museum
Authors: S. Fekete
Journal: JAMA (1965)

<h3>To the Editor:—</h3> On the occasion of the centenary of the death of Ignace Semmelweis (Aug 13, 1965) the Hungarian Ministry of Health established a museum in the house in which Semmelweis had been born. A tomb was constructed at the far end of the house in which have been placed the mortal remains of Semmelweis. In front of the tomb stands the statue titled "Motherhood," which was executed by the Hungarian sculptor, Miklós Borsos. The house stands at the foot of the Castle Hill, Várhegy, in Buda. Semmelweis' father had managed a prosperous general store, also located at this site. The house was built originally at the beginning of the 18th century in the style of Louis XVI. It has 13 windows facing the street and was spacious according to middle-class standards of that time. The façade has been decorated with lovely garlands. The structure has been officially declared
Evolving Data about Subtrochanteric Fractures and Bisphosphonates
Authors: Elizabeth Shane
Journal: New England Journal of Medicine (2010)

Osteoporosis, a skeletal disorder characterized by reduced bone strength that predisposes to an increased risk of fracture, affects 10 to 12 million people in the United States. In 2000, there were 9 million fractures worldwide, of which 1.6 million were hip fractures. Fractures are important because of their association with an increased rate of death, substantial morbidity, enormous costs, and devastating effects on independence and quality of life.Bisphosphonates, the major class of drugs used to treat osteoporosis,1,2 decrease osteoclast-mediated bone resorption and bone turnover markers and increase bone mineral density. They have been shown to reduce the risk . . .
Biologically Active Cortisol in Plasma of Oestrogen-treated and Normal Subjects
Authors: C. W. Burke
Journal: BMJ (1969)

Biologically active (non-protein-bound) cortisol levels in the plasma of 13 women taking oral contraceptives and of 67 normal subjects were compared, using a new method-steady-state gel filtration. Both total and unbound cortisol levels in the 67 normal subjects showed a skew distribution, which was roughly log-normal.Unbound cortisol levels in 11 of the oestrogen-treated women were in the normal range, but the median value was significantly increased in this group. Total plasma cortisol levels in the oestrogen-treated group were, as expected, increased threefold, and all were outside the normal range.
MORPHINOMANIA TREATED SUCCESSFULLY WITH ATROPINE AND STRYCHNINE
Authors: M. S. P. Strangman
Journal: BMJ (1907)

HINOMANIA1 [IJOU3AZ 1173 proximal ends to the cut proximal ends of the dorsal nerve- roots previously divided, thus- A. corresponding junction was also made in the left side.It was hoped that by so doing a path might be provided for the possible transference of nerve Impulses-aefferent, efferent, and trophic-across the gap caused by the crushed portion of the
Weekly Fluconazole for Preventing Mucosal Candidiasis in HIV Infection
Authors: Guy Baily
Journal: Annals of Internal Medicine (1997)

Letters15 December 1997Weekly Fluconazole for Preventing Mucosal Candidiasis in HIV InfectionGuy Baily, MB, MRCPGuy Baily, MB, MRCPSt. Bartholomew's Hospital; London, United KingdomSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Schuman and colleagues [1] studied low-dose fluconazole (200 mg weekly) as secondary prophylaxis of mucosal candidiasis in HIV-infected women. Although their study was longer than most prospective studies done in this area, their results should not be used to support the widespread use of this regimen as they recommend. We have been here before. When fluconazole first became available, studies in HIV-infected men similarly showed that prophylaxis was effective in reducing relapses of oropharyngeal candidiasis over the short term. As a result, continuous use of low-dose fluconazole became a common and routine treatment in many HIV treatment ...References1. Schuman P, Capps L, Peng G, Vazquez J, El-Sadr W, Goldman AI, et al. Weekly fluconazole for the prevention of mucosal candidiasis in women with HIV infection. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1997; 126:689-96. Google Scholar2. Baily GG, Perry FM, Denning DW, Mandal BK. Fluconazole resistant candidosis in an HIV cohort. AIDS. 1994; 8:787-92. Google Scholar3. Maenza JR, Keruly JC, Moore RD, Chaisson RE, Merz MG, Gallant JE. Risk factors for fluconazole-resistant candidiasis in human immunodeficiency virus-infected patients. J Infect Dis. 1996; 173:219-25. Google Scholar4. Heald AE, Cox GM, Schell WA, Bartlett JA, Perfect JR. Oropharyngeal yeast flora and fluconazole resistance in HIV infected patients receiving long-term continuous versus intermittent fluconazole therapy. AIDS. 1996; 10:263-2. Google Scholar5. Johnson EM, Warnock DW, Luker J, Porter SR, Scully C. Emergence of azole drug resistance in Candida species from HIV-infected patients receiving prolonged fluconazole therapy for oral candidosis. J Antimicrob Agents Chemother. 1995; 35:103-14. Google Scholar Author, Article, and Disclosure InformationAffiliations: St. Bartholomew's Hospital; London, United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUse of prophylactic antifungals in the immunocompromised host 15 December 1997Volume 127, Issue 12Page: 1131KeywordsCandida albicansCandidiasisHIVHIV infectionsProphylaxisProspective studies Issue Published: 15 December 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Private Drinking Water Wells as a Source of Exposure to Perfluorooctanoic Acid (PFOA) in Communities Surrounding a Fluoropolymer Production Facility
Authors: Kate Hoffman, Thomas F. Webster, Scott M. Bartell, Marc G. Weisskopf, Tony Fletcher, Verónica M. Vieira
Journal: Environmental Health Perspectives (2010)

BackgroundThe C8 Health Project was established in 2005 to collect data on perfluorooctanoic acid (PFOA, or C8) and human health in Ohio and West Virginia communities contaminated by a fluoropolymer production facility.ObjectiveWe assessed PFOA exposure via contaminated drinking water in a subset of C8 Health Project participants who drank water from private wells.MethodsParticipants provided demographic information and residential, occupational, and medical histories. Laboratory analyses were conducted to determine serum-PFOA concentrations. PFOA data were collected from 2001 through 2005 from 62 private drinking water wells. We examined the relationship between drinking water and PFOA levels in serum using robust regression methods. As a comparison with regression models, we used a first-order, single-compartment pharmacokinetic model to estimate the serum:drinking-water concentration ratio at steady state.ResultsThe median serum PFOA concentration in 108 study participants who used private wells was 75.7 μg/L, approximately 20 times greater than the levels in the U.S. general population but similar to those of local residents who drank public water. Each 1 μg/L increase in PFOA levels in drinking water was associated with an increase in serum concentrations of 141.5 μg/L (95% confidence interval, 134.9–148.1). The serum:drinking-water concentration ratio for the steady-state pharmacokinetic model was 114.ConclusionsPFOA-contaminated drinking water is a significant contributor to PFOA levels in serum in the study population. Regression methods and pharmacokinetic modeling produced similar estimates of the relationship.
Applied Physiology — Youthful Smokers — Life on Wheels
Authors: John Lister
Journal: New England Journal of Medicine (1957)

SPEAKING at the annual dinner of the Cambridge Graduates Club of St. Bartholomew's Hospital, Sir Henry Dale, O.M., G.B.E., F.R.S., explained how it came about that he only spent a short time at his own hospital after graduation. He had already tried his hand at physiologic research when he was offered the post of intern to Dr. Samuel Gee. In making him the offer Dr. Gee told him that when he entered his wards he must forget all his physiology, which was an experimental science; medicine was not — it must be regarded as an empirical art, and that was . . .
Herpesvirus-Mediated Systemic Delivery of Nerve Growth Factor
Authors: Darren Wolfe, William F. Goins, Theodore J. Kaplan, Saverio V. Capuano, Julie Fradette, Michael Murphey-Corb, Paul D. Robbins, Justus B. Cohen, Joseph C. Glorioso
Journal: Molecular Therapy (2001)

Sustained systemic dissemination of therapeutic proteins from peripheral sites is an attractive prospect for gene therapy applications. Replication-defective genomic herpes simplex virus type 1 (HSV-1) vectors were evaluated for their ability to express nerve growth factor (NGF) as a model gene product both locally and systemically. Intra-articular inoculation of NGF expression vectors in rabbits resulted in significant increases in joint lavage and blood plasma NGF that persisted for 1 year. A rhesus macaque injected intra-articularly displayed a comparable increase in plasma NGF for at least 6 months, at which time the serum NGF levels of this animal were sufficient to cause differentiation of PC12 cells in culture, but not to increase footpad epidermis innervation. Long-term reporter transgene expression was observed primarily in ligaments, a finding confirmed by direct inoculation of patellar ligament. Patellar ligament inoculation with a NGF vector resulted in elevated levels of circulating NGF similar to those observed following intra-articular vector delivery. These results represent the first demonstration of sustained systemic release of a transgene product using HSV vectors, raising the prospect of new applications for HSV-1 vectors in the treatment of systemic disease.
The Effect of Adrenergic Blockade on the Glucagon Responses to Starvation and Hypoglycemia in Man
Authors: Robert M. Walter, R. James Dudl, Jerry P. Palmer, John W. Ensinck
Journal: Journal of Clinical Investigation (1974)

In an attempt to ascertain whether the sympathetic nervous system modulates glucagon release in man during starvation and hypoglycemia, the influence of alpha and beta adrenergic blockade on glucagon responses was studied in young, healthy men subjected to fasting and insulin-induced hypoglycemia. Six volunteers fasted for 84 h on three separate occasions. Plasma immunoreactive glucagon (IRG), measured initially at 12 h, climbed gradually from mean levels of 54 pg/ml to a zenith of 124 pg/ml at 48 h, with maintenance of these levels for the duration of the fast. The infusion of propranolol or phentolamine throughout the terminal 24 h of the second and third fasts failed to alter the pattern of IRG release. After an overnight fast, five volunteers received insulin intravenously, which evoked a mean rise in plasma IRG levels from 63 pg/ml to a maximum of 256 pg/ml at 30 min. The concurrent administration of propranolol or phentolamine did not modify the glucagon responses to insulin-induced hypoglycemia. These data suggest that the augmented glucagon release in man during starvation or after hypoglycemia is not significantly regulated by signals from the adrenergic nervous system.
Twin Pregnancy Resulting in the Birth of a Viable Infant and a Blighted Fetus
Authors: Themistocles N. Zervas
Journal: New England Journal of Medicine (1953)

THE possibility of the birth of a viable infant at or near term accompanied by a blighted twin fetus delivered before the seventh month of gestation has been known for many years. Reference to such occurrences has been made in many of the older handbooks of midwifery, such as those of Guilleneau (1594), Peu (1694), Mauriceau (1695), Chapman (1735), Burton (1751), Smellie (1752), Albert Haller (Elements of Physiology, 1780), and Krause (1853). Ramsbotham states that this condition was remarked upon by Pliny. Despite the availability of this knowledge, many references to such occurrences during the last century are in the . . .
THROMBOSIS OF THE CENTRAL RETINAL VEIN AND ITS BRANCHES
Authors: ALLEN GREENWOOD
Journal: JAMA (1924)

In the opening paragraph of a paper on thrombosis of the retinal veins after influenza, Dr. Edward Jackson<sup>1</sup>says: "The clinical course and exact pathological changes of obstruction of the retinal vessels are still so imperfectly known, that we are justified in recording additional cases that seem to be of this character." It would appear, then, that bringing this subject up occasionally for discussion should be helpful. My principal purpose, however, in the present communication is twofold: (1) to place on record a case of thrombosis of the central retinal vein, which, from a study of the literature, appears to be unique in many ways, and (2) to urge that all such cases be carefully investigated and thoroughly treated, even if some of the authorities consider that treatment accomplishes little. A sudden obstruction, or a slowly developing obstruction to the flow of blood in the central retinal vein will,
Das Kind als Identifikationsobjekt seiner Eltern
Authors: Armo Hormia
Journal: Psychotherapy and Psychosomatics (1960)

Research Articles| February 10 2010 Das Kind als Identifikationsobjekt seiner Eltern Subject Area: Psychiatry and Psychology Armo Hormia Armo Hormia Turku (Finnland) Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1960) 8 (1): 44–52. https://doi.org/10.1159/000285503 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Armo Hormia; Das Kind als Identifikationsobjekt seiner Eltern. Acta Psychotherapeutica et Psychosomatica 1 January 1960; 8 (1): 44–52. https://doi.org/10.1159/000285503 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1960Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Possibility for an Immobilized Flavin Fuel Cell Electrode for Glucose Measurements
Authors: Lemuel B Wingard
Journal: Diabetes Care (1982)

Preliminary work is described on the attachment of riboflavin to solid carbon via a coupling group that should provide a pathway for easy electron transfer. Such an approach, when extended to the flavin cofactor portion of glucose oxidase, has the possibility of forming a fuel cell electrode of high specificity for glucose and in which the current would be related to the concentration of glucose.