tbuckley/cabot-search huggingface dataset:
Criteria for the Diagnosis of Malnutrition
Authors: David B. Cockram
Journal: JAMA (1987)

To the Editor.—  The art and science of nutritional assessment requires an awareness of who may be at nutritional risk, as well as understanding of the physical signs and symptoms of undernutrition and the effects of medications and underlying diseases on nutritional status. Two recent JAMA articles demonstrate this point clearly. In the first, 1 the serum albumin level was used as the sole indicator of nutritional status in individuals with adenomatous polyps and colon cancer. The serum albumin level was used as the covariate to correct the serum cholesterol level for malnutrition. The authors concluded that the low cholesterol levels observed during these conditions are consequences, rather than predictors, of the diseases.  The difficulty of using serum protein levels as nutritional markers was pointed out by Craig 2 in a letter regarding the first article. He stated that determination of nutritional status without an appreciation of the impact of
Stone tools and conceptual structure
Authors: James Steele
Journal: Behavioral and Brain Sciences (1995)

Abstract Understanding how conceptual structures inform stone tool production and use would help us resolve the issue of a pongid-hominid dichotomy in brain organisation and cognitive ability. Evidence from ideational apraxia suggests that the planning of linguistic and manipulative behaviours is not colocalized in homologous circuits. An alternative account in terms of the evolutionary expansion of the whole prefrontal-premotor area may be more plausible.
ICTERUS WITHOUT HAEMOGLOBINURIA AFTER QUININE TREATMENT
Authors: G. R. Ross, G. H. Peall
Journal: BMJ (1927)

ICTERUS WITHOUT HAEMOGLOBINUIMIA AFTER QUININE.rDTHCTALUA 5 53 perimeters seem to be admirably adapted for the delimita- tion of scotomata.Many years ago (1888)-Dr.George Mackay, also of Edinburgh, exhibited at the Glasgowimeeting of the British Medical Association a large circular perimeter, -hlich perhaps fulfilled to some extent the purposes of a large tangent screen.As has been shown, the ordinary .circularperimeters often fail to reiveal importanit defects in the field of vision, which at once become apparent when
Über Kurztherapie neurotischer Störungen
Authors: R. Furger
Journal: Psychotherapy and Psychosomatics (1965)

Research Articles| February 11 2010 Über Kurztherapie neurotischer Störungen Subject Area: Psychiatry and Psychology R. Furger R. Furger Psychiatrische Universitäts-Poliklinik, Zürich (Direktor: Prof. M. Bleuler, leitender Arzt: PD H. Kind) Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1965) 13 (6): 434–448. https://doi.org/10.1159/000285803 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation R. Furger; Über Kurztherapie neurotischer Störungen. Psychother Psychosom 1 June 1965; 13 (6): 434–448. https://doi.org/10.1159/000285803 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1965Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Effect of Exercise Training on Myocardial Remodeling in Patients With Reduced Left Ventricular Function After Myocardial Infarction
Authors: Paul Dubach, Jonathan Myers, Gerald Dziekan, Ute Goebbels, Walter Reinhart, Paul Vogt, Reto Ratti, Peter Muller, Risto Miettunen, Peter Buser
Journal: Circulation (1997)

Background There are conflicting reports on the effects of training on the remodeling process in post–myocardial infarction patients with ventricular damage. Methods and Results Twenty-five patients with reduced ventricular function (mean ejection fraction, 32.3±6%) after an anteroseptal or inferolateral myocardial infarction were randomized to an exercise group (n=12) or a control group (n=13). Patients in the exercise group resided in a rehabilitation center for 2 months and underwent a training program consisting of two 1-hour sessions of walking daily, along with four monitored 45-minute sessions of stationary cycling weekly. Before and after the study period, maximal exercise testing and cardiac MRI were performed. Oxygen uptake increased 26% at maximal exercise (19.7±3 to 23.9±5, P &lt;.05) and 39% at the lactate threshold ( P &lt;.01) in the exercise group, whereas control values did not change. No differences were observed within or between groups in MRI measures of end-diastolic (187±47 pre versus 196±35 mL post in the exercise group and 179±52 pre versus 180±51 mL post in the control group), end-systolic volume (118±41 pre versus 121±33 mL post in the exercise group and 119±54 pre versus 116±56 mL post in the control group), or ejection fraction (38.0±9 pre versus 38.2±10% post in the exercise group and 37.0±10 pre versus 38.3±13% post in the control group). Myocardial wall thickness measurements at end diastole and end systole and their difference in 80 myocardial segments determined by MRI yielded no significant interactions between groups. When myocardial wall thickness measurements were classified by infarct or noninfarct areas, no differences were observed between groups over the study period. Conclusions A high-intensity, 2-month residential cardiac rehabilitation program resulted in substantial increases in exercise capacity among patients with reduced left ventricular function. In contrast to some recent reports, the training program had no deleterious effects on left ventricular volume, function, or wall thickness regardless of infarct area.
Treatment of burns and donor sites with human allogeneic keratinocytes grown on acellular pig dermis
Authors: E. MATOUŠKOVÁ, S. BUČEK, D. VOGTOVÁ, P. VESELýA, A. CHALOUPKOVÁ, L. BROŽ, H. SINGEROVÁ, L. PAVLÍKOVÁ, R. KÖNIGOVÁ
Journal: British Journal of Dermatology (1997)

The absence of a dermal component predisposes cultured epidermal sheets to instability, contractibility, and makes them difficult to handle. In order to overcome these drawbacks, we developed recombined human/pig skin (RHPS) composed of human keratinocytes cultured on cell-free pig dermis. The original intention to prepare a permanent skin substitute composed of xenodermis and autologous epidermis was not achieved, but it has been proved that RHPS can serve as an effective, ready to use keratinocyte delivery system when applied 'upside-down', i.e. with epidermal cells facing the wound surface. The keratinocyte layer establishes a direct contact with the wound bed, while the dermal layer mechanically protects the wound. Twenty deep dermal burns were grafted with RHPS: 13 (65%) healed completely in 4-14 days, three (15%) healed partially and four (20%) did not heal. Of five full thickness burn wounds only one healed after repeated RHPS grafting within 18 days. Thirty-one (100%) donor sites treated with any of the three forms of RHPS, subconfluent, confluent meshed or confluent unmeshed, healed within 6-8 days compared with 14-18 days in control sites. Seven donor sites (100%) of immunodeficient patients with prolonged wound healing epithelialized in 7-10 days under RHPS compared with 32-90 days in areas treated with tulle gras and dry gauze.
Long-term health-related quality of life evaluated more than 20 years after hematopoietic stem cell transplantation for thalassemia
Authors: Giorgio La Nasa, Giovanni Caocci, Fabio Efficace, Carlo Dessì, Adriana Vacca, Eugenia Piras, Marco Sanna, Michela Marcias, Roberto Littera, Carlo Carcassi, Guido Lucarelli
Journal: Blood (2013)
Precipitating Factors for Delirium in Hospitalized Elderly Persons
Authors: Sharon K. Inouye
Journal: JAMA (1996)

To prospectively develop and validate a predictive model for delirium based on precipitating factors during hospitalization, and to examine the interrelationship of precipitating factors and baseline vulnerability.Two prospective cohort studies, in tandem.General medical wards, university teaching hospital.For the development cohort, 196 patients aged 70 years and older with no delirium at baseline, and for the validation cohort, 312 comparable patients.New-onset delirium by hospital day 9, defined by the Confusion Assessment Method diagnostic criteria.Delirium developed in 35 patients (18%) in the development cohort. Five independent precipitating factors for delirium were identified; use of physical restraints (adjusted relative risk [RR], 4.4; 95% confidence interval [CI], 2.5 to 7.9), malnutrition (RR, 4.0; 95% CI, 2.2 to 7.4), more than three medications added (RR, 2.9; 95% CI, 1.6 to 5.4), use of bladder catheter (RR, 2.4; 95% CI, 1.2 to 4.7), and any iatrogenic event (RR, 1.9; 95% CI, 1.1 to 3.2). Each precipitating factor preceded the onset of delirium by more than 24 hours. A risk stratification system was developed by adding 1 point for each factor present. Rates of delirium for low-risk (0 points), intermediate-risk (1 to 2 points), and high-risk groups (> or equal to 3 points) were 3%, 20%, and 59%, respectively (P < .001). The corresponding rates in the validation cohort, in which 47 patients (15%) developed delirium, were 4%, 20%, and 35%, respectively (P < .001). When precipitating and baseline factors were analyzed in cross-stratified format, delirium rates increased progressively from low-risk to high-risk groups in all directions (double-gradient phenomenon). The contributions of baseline and precipitating factors were documented to be independent and statistically significant.A simple predictive model based on the presence of five precipitating factors can be used to identify elderly medical patients at high risk for delirium. Precipitating and baseline vulnerability factors are highly interrelated and contribute to delirium in independent substantive, and cumulative ways.
Hypopotassemia Following Bilateral Ureterosigmoidostomy
Authors: William C. L. Diefenbach, Shirley C. Fisk, Saul B. Gilson
Journal: New England Journal of Medicine (1951)

BILATERAL ureterosigmoidostomy is frequently a concomitant of present-day urological surgery. The basic indication for this procedure is obstruction, present or anticipated, of the lower urinary tract, and most often is found in instances of tumor resection. Urologic complications and sequelae of ureterosigmoidostomy include fecal urinary fistulas and ascending urinary-tract infections with pyelonephritis and hydronephrosis.1 Even when adequate urinary drainage is maintained, further complications may still ensue. Various insidious disturbances in electrolyte balance may appear.2 A series of 141 cases of ureterosigmoidostomy was reported by Ferris and Odel3; 79 per cent of these developed varying degrees of hyperchloremic acidosis and . . .
740 REACTIVE OXYGEN SPECIES FROM NAD(P)H OXIDASE CONTRIBUTE CARDIAC DYSFUNCTION IN CIRRHOTIC RATS
Authors: G. Ceolotto, A. Bortoluzzi, I. Papparella, M. Cavalli, A. Sticca, S. Bova, A. Semplicini, A. Gatta, P. Angeli
Journal: Journal of Hepatology (2009)
187. Modular Cationic Peptides as Gene Delivery Agents
Authors: Rukkumani Rajagopalan, Jennifer Xavier, Nalam M. Rao, Vijaya Gopal
Journal: Molecular Therapy (2006)

Top of pageAbstract
Peptide-based gene delivery is novel and allows a combinatorial approach to suit specific needs.Our strategy uses the recombinant approach where the major advantage would be the ease with which a large number of peptide combinations could be prepared by bacterial fermentation. By combining motifs with the desired properties of DNA condensation and membrane transduction, the efficiency of transfection could be greatly enhanced particularly in cells that are non-dividing.

We have recently shown that the recombinant peptides, expressed as N-terminal His-Tag fusion proteins, TAT-Mu, TAT-NLS, Mu and Mu-Mu, are capable of transporting DNA effectively into MCF-7, CHO, COS, HeLa and macrophages. TAT constitutes a 11 amino acid region of the HIV-TAT while Mu, of the adenoviral core protein, has 19 amino acids. The nuclear localization sequences (SV 40 NLS) constitutes 3 copies of the sequence present in tandem. These sequences have been cloned in frame in an expression vector. In the case of TAT-Mu and TAT-NLS, transfection was enhanced |[sim]|3 fold in the presence of the cationic lipid DDAB:DOPE. When transfections were performed in the presence of chloroquine, a lysosomotropic agent, the DNA transfection was further enhanced. These results and colocalization with endosomal markers suggests involvement of endocytic pathways in the uptake of the lipopolyplexes. Immunolocalization of the peptide DNA complexes by confocal microscopy, showed that macrophages, HeLa, and MCF-7 cells internalized the peptide:DNA complexes in a time dependent manner with strong nuclear staining in all the cells.

Recombinant methodology to produce a large variety of modular, cationic peptides allows rapid development of cell tropic molecules for gene delivery. Such molecular entities would have great potential in the development and advancement of molecular medicine.
127 A LIVER IN FLOW-OCCLUSION AND HIGH PRESSURE VECTOR INJECTION APPROACH FOR IN VIVO DELIVERY OF LENTIVIRAL VECTOR INTO ADULT HYPERBILIRUBINEMIC GUNN RATS
Authors: T.H. Nguyen, A. Dariel, D. Aubert, V. Pichard, G. Podevin, N. Ferry
Journal: Journal of Hepatology (2008)
Three-Dimensional Culture of Mouse Renal Carcinoma Cells in Agarose Macrobeads Selects for a Subpopulation of Cells with Cancer Stem Cell or Cancer Progenitor Properties
Authors: Barry H. Smith, Lawrence S. Gazda, Bryan L. Conn, Kanti Jain, Shirin Asina, Daniel M. Levine, Thomas S. Parker, Melissa A. Laramore, Prithy C. Martis, Horatiu V. Vinerean, Eric M. David, Suizhen Qiu, Carlos Cordon-Cardo, Richard D. Hall, Bruce R. Gordon, Carolyn H. Diehl, Kurt H. Stenzel, Albert L. Rubin
Journal: Cancer Research (2011)

The culture of tumor cell lines in three-dimensional scaffolds is considered to more closely replicate the in vivo tumor microenvironment than the standard method of two-dimensional cell culture. We hypothesized that our method of encapsulating and maintaining viable and functional pancreatic islets in agarose-agarose macrobeads (diameter 6-8 mm) might provide a novel method for the culture of tumor cell lines. In this report we describe and characterize tumor colonies that form within macrobeads seeded with mouse renal adenocarcinoma cells. Approximately 1% of seeded tumor cells survive in the macrobead and over several months form discrete elliptical colonies appearing as tumor cell niches with increasing metabolic activity in parallel to colony size. The tumor colonies demonstrate ongoing cell turnover as shown by BrdU incorporation and activated caspase-3 and TUNEL staining. Genes upregulated in the tumor colonies of the macrobead are likely adaptations to this novel environment, as well as an amplification of G(1)/S cell-cycle checkpoints. The data presented, including SCA-1 and Oct4 positivity and the upregulation of stem cell-like genes such as those associated with the Wnt pathway, support the notion that the macrobead selects for a subpopulation of cells with cancer stem cell or cancer progenitor properties.
MORPHIA AND ATROPIA BY HYPODERMIC INJECTION PREVIOUS TO THE ADMINISTRATION OF ANÆSTHETICS.
Authors: J. C. REEVE
Journal: JAMA (1884)

The number of this journal for February 9, contains an article upon the above subject by Dr. Aubert, from the proceedings of the<i>Société de Biologie</i>, in which the modification of the action of anæstheticstics by preceding injection of narcotics, seems to be presented as something entirely new, and his experience of the benefits resulting from it is detailed as if nothing similar had been heretofore given to the profession. The fact is that this mode of modifying anæthesia is more than twenty years old. It had its clinical birth under Nussbaum in 1863, and owes its establishment upon a scientific basis to Bernard shortly afterwards.1 Since then it has been gradually making its way in practice. Its merits have been several times presented and urged upon the profession of this country by myself. First, in an article in the<i>American Journal of the Medical Sciences</i>for April, 1876; again
Telephone Care as a Substitute for Routine Clinic Follow-up
Authors: John Wasson
Journal: JAMA (1992)

<h3>Design.</h3> —Randomized trial. <h3>Setting.</h3> —A primary care clinic. <h3>Patients.</h3> —Four hundred ninety-seven men aged 54 years or older. <h3>Objective.</h3> —We examined the hypothesis that substituting clinician-initiated telephone calls (telephone care) for some clinic visits would reduce medical care utilization without adversely affecting patient health. <h3>Intervention.</h3> —Clinicians were asked to double their recommended interval for face-to-face follow-up and schedule three intervening telephone contacts; for control patients, the follow-up interval recommended by their clinician was unchanged. <h3>Main Outcome Measures.</h3> —Use of medical services and health status. <h3>Results.</h3> —During the 2-year follow-up period, 7% of patients withdrew or became unavailable. Telephone-care patients had fewer total clinic visits, scheduled and unscheduled, than usual-care patients (19%,<i>P</i>&lt;.001). In addition, telephone-care patients had less medication use (14%,<i>P</i>=.006), fewer admissions, and shorter stays in the hospital (28% fewer total hospital days,<i>P</i>=.005), and 41% fewer intensive care unit days (<i>P</i>=.03). Estimated total expenditures for telephone care were 28% less per patient for the 2 years ($1656,<i>P</i>=.004). For the subgroup of patients with fair or poor overall health at the beginning of the study (n= 180), savings were somewhat greater ($1976,<i>P</i>=.01). In this subgroup, improvement in physical function from baseline (<i>P</i>=.02) and a possible reduction in mortality (<i>P</i>=.06) were also observed. <h3>Conclusion.</h3> —We conclude that substituting telephone care for selected clinic visits significantly reduces utilization of medical services. For more severely ill patients, the increased contact made possible by telephone care may also improve health status and reduce mortality. (<i>JAMA</i>. 1992;267:1788-1793)
Surgeon faces medical council hearing over botched operations.
Authors: Owen Dyer
Journal: BMJ (2001)

Two anaesthetists told the General Medical Council this week that they had refused to continue working with a consultant general surgeon at the Victoria Hospital, Blackpool, who lost five women patients to excessive bleeding between 1995 and 1999.

Steven Walker, 44, stands accused of serious professional misconduct over 12 operations: five bowel operations, five breast reconstructions, and two liver resections. Rebecca Poulet QC, prosecuting, said Mr Walker's overoptimistic assessment of his clinical skills led him to take on surgery in which he had no training or experience. Retired anaesthetist Helen Matheson told the GMC's professional …
NMR — Another Cancer-Test Disappointment
Authors: Robert Shulman
Journal: New England Journal of Medicine (1990)

Nuclear magnetic resonance (NMR) has been used in basic research by physicists, chemists, and biochemists since its invention in 1946. In the past decade it has been applied in medicine, particularly with the development of magnetic resonance imaging, which produces detailed structural images by measuring the spatial distribution of water. The revolutionary advances made with magnetic resonance imaging have stimulated interest in the use of NMR spectroscopy in vivo to determine the concentrations of metabolites noninvasively and follow changes in their concentrations over time. In both magnetic resonance imaging and NMR spectroscopy, the patient is placed in a large cylindrical . . .
Spontaneous uterine rupture caused by placenta percreta.
Authors: A. M. Hassim, C. Lucas, S. A. Elkabbani
Journal: BMJ (1968)

Preli'minary Conuuluications MWI JOUMA 97 Considerable variation was found from case to case in the pro- portion of cells containing glycogen.Weak P.A.S. positivity was significantly related to short first tained remission and survival, high initial peripheral blood blast count, and short duration of symptoms at the time of diagnosis.The results suggest that P.A.S. positivity is inversely related to the rate of progression of lymphoblastic leukaea.
INFLUENZA IN HORSE AND MULE
Authors: G. A Roberts
Journal: JAMA (1918)

<h3>To the Editor:</h3> —Physicians are aware of a disease in horses and mules called "influenza." It is misnamed, because it is not due to the same cause as influenza of man. However, it may be of interest to know that this disease in horses and mules bears a wonderfully striking resemblance to influenza in man, both in the influenza itself and in its complications. Influenza in the horse and mule is confined almost exclusively to so-called green horses, namely, those shipped to infected sales stables for the first time. One attack usually produces immunity, but not always. The disease is more or less common during the shipping season every year, but the complications vary greatly from year to year as to their frequency and the virulence of the secondary infection. Such a history is not unlike that of influenza of man. The cause of influenza in the horse and mule