tbuckley/cabot-search huggingface dataset:
Biphasic Ferrogels for Triggered Drug and Cell Delivery
Authors: Christine A. Cezar, Stephen M. Kennedy, Manav Mehta, James C. Weaver, Luo Gu, Herman Vandenburgh, David J. Mooney
Journal: Advanced Healthcare Materials (2014)

Ferrogels are an attractive material for many biomedical applications due to their ability to deliver a wide variety of therapeutic drugs on‐demand. However, typical ferrogels have yet to be optimized for use in cell‐based therapies, as they possess limited ability to harbor and release viable cells. Previously, an active porous scaffold that exhibits large deformations and enhanced biological agent release under moderate magnetic fields has been demonstrated. Unfortunately, at small device sizes optimal for implantation (e.g., 2 mm thickness), these monophasic ferrogels no longer achieve significant deformation due to a reduced body force. A new biphasic ferrogel, containing an iron oxide gradient, capable of large deformations and triggered release even at small gel dimensions, is presented in this study. Biphasic ferrogels demonstrate increased porosity, enhanced mechanical properties, and potentially increased biocompatibility due to their reduced iron oxide content. With their ability to deliver drugs and cells on‐demand, it is expected that these ferrogels will have wide utility in the fields of tissue engineering and regenerative medicine.
Mortality of S. aureus bacteremia and infectious diseases specialist consultation – A study of 521 patients in Germany
Authors: Siegbert Rieg, Gabriele Peyerl-Hoffmann, Katja de With, Christian Theilacker, Dirk Wagner, Johannes Hübner, Markus Dettenkofer, Achim Kaasch, Harald Seifert, Christian Schneider, Winfried V. Kern
Journal: Journal of Infection (2009)
Crohn's disease in Nottingham: a search for time-space clustering.
Authors: D S Miller, A Keighley, P G Smith, A O Hughes, M J Langman
Journal: Gut (1975)

All cases of Crohn's disease in the Nottingham area were ascertained and the date and place of domicile and work at the time of onset of symptoms noted. Applying the Knox and Pike and Smith tests for clustering of patients in time and space, no significant results were observed. Further analysis of differences in time-space clustering between a group of patients and matched controls is in hand.
Book Review Current Research and Clinical Management of Melanoma (Cancer Treatment and Research Volume 65) Edited by Larry Nathanson. 388 pp., illustrated. Boston, Kluwer Academic, 1993. $195. 0-7923-2152-9 Malignant Melanoma: Medical and Surgical Management Edited by Ferdy J. Lejeune, Prabir K. Chaudhuri, and Tapas K. Das Gupta. 383 pp., illustrated. New York, McGraw-Hill, 1994. $35. 0-07-105421-9
Authors: Israel Penn
Journal: New England Journal of Medicine (1994)
HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse
Authors: Kathleen A. Connell, Marsha K. Guess, Heidi Chen, Vaagn Andikyan, Richard Bercik, Hugh S. Taylor
Journal: Journal of Clinical Investigation (2008)

Pelvic organ prolapse (POP) is a common, debilitating disorder affecting millions of women. Uterosacral ligaments (USLs) are the main supportive structures of the uterus and vagina and are often attenuated in women with POP. Although the mechanical strength of USLs is known to be dependent on collagen synthesis and catabolism and the degradation protein MMP2 has been implicated in POP, the molecular mechanisms involved in the development of POP are currently unknown. Homeobox (HOX) genes are transcriptional regulators that orchestrate embryonic development of the urogenital tract. We demonstrated here that HOXA11 was essential for organogenesis of the USL by showing that USLs were absent in Hoxa11-null mice. We compared expression of HOXA11, collagen type I, collagen type III, MMP2, and MMP9 in USLs of women with and without POP. Expression of HOXA11 and both collagens was dramatically decreased while MMP2 was increased in women with POP. Constitutive expression of Hoxa11 in murine fibroblasts resulted in significantly increased expression of collagen type III and decreased expression of MMP2. These results identified HOXA11 as an essential gene for the development of the USL and suggested that women with POP might have weakened connective tissue due to changes in a signaling pathway involving HOXA11, collagen type III, and MMP2.
Existential Analysis and Psychotherapy
Authors: Ludwig Binswanger
Journal: Psychotherapy and Psychosomatics (1955)

Research Articles| January 20 2010 Existential Analysis and Psychotherapy Subject Area: Psychiatry and Psychology Ludwig Binswanger Ludwig Binswanger Kreuzlingen, Switzerland Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1955) 3 (Suppl. 1): 33–38. https://doi.org/10.1159/000278628 Article history Published Online: January 20 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ludwig Binswanger; Existential Analysis and Psychotherapy. Acta Psychotherapeutica et Psychosomatica 1 January 1955; 3 (Suppl. 1): 33–38. https://doi.org/10.1159/000278628 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1955Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Effect of acetaminophen on human gastric mucosal injury caused by ibuprofen.
Authors: F L Lanza, G L Royer, R S Nelson, M F Rack, C E Seckman, J H Schwartz
Journal: Gut (1986)

Acetaminophen has been proposed as an agent which protects the gastric mucosa against damage induced by aspirin and other non-steroidal anti-inflammatory agents. In order to evaluate this proposal further, 45 normal human volunteers were divided into three groups (n = 15); group one received ibuprofen 2400 mg daily (600 mg qid); group two received acetaminophen 3900 mg daily (975 mg qid) and group three received both drugs at the same dosages. There was no significant difference in the mucosal injury scores noted at endoscopy between the ibuprofen and the ibuprofen-acetaminophen group. The acetaminophen group had virtually no observed mucosal injury and this was statistically significant in comparison with the other groups (p less than 0.01). We conclude that contrary to previously reported studies using single doses of aspirin, acetaminophen failed to decrease the mucosal injury seen with ibuprofen when given for a period of seven days in combination with acetaminophen.
Illustrated Textbook of Gynaecology
Authors: Irwin E. Thompson
Journal: JAMA (1984)

Four distinguished obstetrician-gynecologists from Australia have authored this book, aimed at medical students, nurses, and general practitioners. As indicated in the preface, a middle course has been chosen between a specialized monograph and a brief general text. Therefore, the book is most comprehensive in scope and contains 42 chapters covering every aspect of gynecology, although specific references at the end of each chapter are deliberately omitted.  The book admirably attains the stated objectives and, in fact, provides a very useful overview of the current practice of gynecology. It is profusely illustrated with excellent line drawings and photographs, some of which are spectacular. These illustrations are accompanied by very long legends—a didactic technique that I found to be useful and interesting. The subject matter is organized into three main groups of chapters— general gynecologic topics from anatomy through clinical gynecology to sexuality and contraception; regional gynecology with consideration of the benign
Recapitulation ofin vivo gene expression during hepatic differentiation from murine embryonic stem cells
Authors: Yusuke Yamamoto, Takumi Teratani, Hanako Yamamoto, Gary Quinn, Sigenori Murata, Rieko Ikeda, Kenji Kinoshita, Kenichi Matsubara, Takashi Kato, Takahiro Ochiya
Journal: Hepatology (2005)

Abstract Hepatic differentiation at the molecular level is poorly understood, mainly because of the lack of a suitable model. Recently, using adherent monoculture conditions, we demonstrated the direct differentiation of hepatocytes from embryonic stem (ES) cells. In this study, we exploited the direct differentiation model to compare the gene expression profiles of ES cell–derived hepatocytes with adult mouse liver using DNA microarray technology. The results showed that the ES cell–derived hepatocyte gene expression pattern is very similar to adult mouse liver. Through further analysis of gene ontology categories for the 232 most radically altered genes, we found that the significant categories related to hepatic function. Furthermore, through the use of small interfering RNA technology in vitro , hepatocyte nuclear factor 3β/FoxA2 was identified as having an essential role in hepatic differentiation. These results demonstrate that ES cell–derived hepatocytes recapitulate the gene expression profile of adult mouse liver to a significant degree and indicate that our direct induction system progresses via endoderm differentiation. In conclusion , our system closely mimics in vivo hepatic differentiation at the transcriptional level and could, therefore, be useful for studying the molecular basis of hepatocyte differentiation per se. (Hepatology 2005.)
Confocal laser endomicroscopy: a novel method for prediction of relapse in Crohn’s disease
Authors: John Karstensen, Adrian Săftoiu, Jørn Brynskov, Jakob Hendel, Pia Klausen, Tatiana Cârtână, Tobias Klausen, Lene Riis, Peter Vilmann
Journal: Endoscopy (2015)

<b>Background and study aims:</b> Confocal laser endomicroscopy (CLE) has been shown to predict relapse in ulcerative colitis in remission, but little is currently known about its role in Crohn’s disease. The aim of this study was to identify reproducible CLE features in patients with Crohn’s disease and to examine whether these are risk factors for relapse. <b>Patients and methods:</b> This was a single-center prospective feasibility study of CLE imaging in patients with Crohn’s disease. CLE imaging was performed in the terminal ileum and four colorectal sites, and was correlated with histopathology and macroscopic appearance. Clinical relapse, defined as the need for treatment escalation or surgical intervention, was recorded during follow-up. <b>Results:</b> The study included 50 patients: 39 with Crohn’s disease (20 in remission), and 11 controls. Ileal fluorescein leakage and microerosions were significantly more frequent in patients with endoscopically active Crohn’s disease compared with patients with inactive Crohn’s disease and controls (<i>P</i> = 0.005 and (<i>P</i> = 0.006, respectively). The same applied to colorectal fluorescein leakage and vascular alterations ((<i>P</i> = 0.043 and (<i>P</i> = 0.034, respectively). During a 12-month follow-up period, ileal fluorescein leakage and microerosions were significant risk factors for relapse in the subgroup of patients in remission (log rank (<i>P</i> = 0.009 and (<i>P</i> = 0.007, respectively) as well as in the entire group of patients with Crohn’s disease (log rank (<i>P</i> = 0.006 and (<i>P</i> = 0.01, respectively). Inter- and intraobserver reproducibility was almost perfect (κ > 0.80) or substantial (κ > 0.60) for the majority of CLE parameters. <b>Conclusions:</b> CLE can identify reproducible microscopic changes in the terminal ileum that are risk factors for relapse in patients with otherwise inactive Crohn’s disease. Trial registration: ClinicalTrials.gov (NCT01738529).
Incidence and risk factors for new-onset atrial fibrillation among patients with end-stage renal disease undergoing renal replacement therapy
Authors: Jo-Nan Liao, Tze-Fan Chao, Chia-Jen Liu, Kang-Ling Wang, Su-Jung Chen, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Ta-Chuan Tuan, Fa-Po Chung, Tzeng-Ji Chen, Shih-Ann Chen
Journal: Kidney International (2015)
Disorders of the outflow tract of the left ventricle.
Authors: J. F. Goodwin
Journal: BMJ (1967)

pressure load, which leads to concenti ic hypertrophy, the wall thickness increasing disproportionately to the size of the cavity, which remains small.Grant et al. ( 1965) have studied relative wall thickness in patients with obstruction to left ventricular outflow and those with a volume load due to regurgitation.tion may occur in patients who have fixed or variable obstruction to outflow.In the absence of obstruction to outflow, lesions which distort, obliterate, or destroy the cavity of the left BIu SH
Intrahepatic Cholestasis in Childhood
Authors: Jenny Heathcote, Kamalakar P. Deodhar, Peter J. Scheuer, Sheila Sherlock
Journal: New England Journal of Medicine (1976)

The apparent well-being of some children who as neonates were believed to have obstructive jaundice prompted us to study the clinical course, histologic features and possible etiologic factors in 17 children with cholestasis in the neonatal period. During a follow-up period of five months to 22 years, all had signs of chronic cholestasis, but only four died (two from nonhepatic causes); the others live remarkably normal lives. Serial hepatic biopsies in 11 showed a variety of initial lesions, which progressed to hypoplasia of the intrahepatic bile ducts, increasing portal fibrosis and eventual cirrhosis. Although evidence of possible viral infection was found in only 10 cases, a hepatitis, beginning either before or after birth, appears to be a likely original cause. The histologic changes seen may represent different stages of one process, starting as cholestasis with or without evidence of hepatitis and progressing to obliteration or failure of normal growth of the intrahepatic bile ducts.
Carlo Forlanini, the Dermatologist Who Invented the Cure for Pulmonary Tuberculosis
Authors: Filippo Pesapane, Antonella Coggi, Raffaele Gianotti
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer
Authors: Akseli Hemminki, Päivi Peltomäki, Jukka-Pekka Mecklin, Heikki Järvinen, Reijo Salovaara, Minna Nyström-Lahti, Albert de la Chapelle, Lauri A. Aaltonen
Journal: Nature Genetics (1994)
Targeting Specific Regions of the Notch3 Ligand-Binding Domain Induces Apoptosis and Inhibits Tumor Growth in Lung Cancer
Authors: Luping Lin, Ray Mernaugh, Fuming Yi, David Blum, David P. Carbone, Thao P. Dang
Journal: Cancer Research (2010)

Abstract Like many signaling pathways in development, the Notch receptor pathway plays an important role in cancer pathobiology when it is dysregulated. Potential ligand-binding sites within the epidermal growth factor (EGF)–like repeats of Notch1 have been identified, but the ligand-binding domains in Notch3, which is implicated in lung cancer, are not known. In screening a library of 155 peptides representing all 34 EGF-like repeats in Notch3, we discovered two distinct ligand-binding regions involving the 7–10 and 21–22 repeats that are distinct from the putative ligand-binding domain of Notch1. In cell-based assays, peptides from these regions induced apoptosis and reduced expression of the Notch3-dependent gene Hey1. They also bound directly to the Notch ligand Jagged1, suggesting that their mechanism of action involves disrupting interactions between Notch3 and Jagged1. Recombinant Fc fusion peptides engineered for in vivo testing showed that the Notch3 peptides defined could trigger apoptosis and suppress tumor growth in tumor xenograft assays. These findings rationalize a mechanistic approach to lung cancer treatment based on Notch3 receptor–targeted therapeutic development. Cancer Res; 70(2); 632–8
Molecular heterogeneity of familial porphyria cutanea tarda in Spain: characterization of 10 novel mutations in the UROD gene
Authors: M. Méndez, P. Poblete-Gutiérrez, M. García-Bravo, T. Wiederholt, M.J. Morán-Jiménez, H.F. Merk, M.C. Garrido-Astray, J. Frank, A. Fontanellas, R. Enríquez de Salamanca
Journal: British Journal of Dermatology (2007)

Porphyria cutanea tarda (PCT) results from decreased hepatic uroporphyrinogen decarboxylase (UROD) activity. In the majority of patients, the disease is sporadic (S-PCT or type I) and the enzyme deficiency is limited to the liver. Familial PCT (F-PCT or type II) is observed in 20-30% of patients in whom mutations on one allele of the UROD gene reduce UROD activity by approximately 50% in all tissues. Another variant of PCT (type III) is characterized by family history of the disease although it is biochemically indistinguishable from S-PCT.To investigate the molecular basis of PCT in Spain and to compare enzymatic and molecular analysis for the identification of patients with F-PCT.Erythrocyte UROD activity measurement and mutation analysis of the UROD gene were carried out in a cohort of 61 unrelated Spanish patients with PCT and 50 control individuals. Furthermore, each novel missense mutation identified was characterized by prokaryotic expression studies.Of these 61 patients, 40 (66%) were classified as having S-PCT, 16 (26%) as having F-PCT and five (8%) as having type III PCT. Discordant results between enzymatic and molecular analysis were observed in two patients with F-PCT. In total, 14 distinct mutations were found, including 10 novel mutations: five missense, one nonsense, three deletions and an insertion. Prokaryotic expression of the novel missense mutations demonstrated that each results in decreased enzyme activity or stability.These results confirm the high degree of molecular heterogeneity of F-PCT in Spain and emphasize the usefulness of molecular genetic analysis to distinguish between F-PCT and S-PCT.
Thorax 1996-2002
Authors: A Knox, J Britton
Journal: Thorax (2006)

The year 1996 was a strange one. Dolly the sheep was cloned and Britain was embroiled in an epidemic of mad cow disease. Nottingham Forest football team were in the premier league. Amid this confusion, two different beasts were appointed to the editorship of Thorax , one a cell biologist and the other an epidemiologist. This was the first time Thorax had joint editors rather than a dictatorial structure. Would it work? How would we run the journal?

The main indicator of scientific quality of a journal then, as now, was the impact factor and, for all its failings, it at least provided something objective which was measurable against comparator journals. At that time the impact factor of Thorax was rather low and we were concerned that, as competitor journals expanded, we might be left in their wake. We decided that lean and mean was best. We would concentrate on quality at the expense of quantity and hope that by publishing only the best papers we would improve the impact factor. Hopefully this would then make the journal more appealing to contributors for their better papers, and there would be a positive spiral with this policy increasing the number of good …
IMPROVED TENDON TUCKER.
Authors: FRANK C. TODD
Journal: JAMA (1903)

I desire to show the Section a tendon tucker, which is an improvement over my instrument shown at the session last year. The principle of this instrument is the same, the only difference being that the adjustment is made at the distal end of the instrument, where it is more easily handled. The operation was described in the<i>Ophthalmic Record</i>, February, 1902.