tbuckley/cabot-search huggingface dataset:
Oncolytic Herpes Simplex Virus Vector Therapy of Breast Cancer in C3(1)/SV40 T-antigen Transgenic Mice
Authors: Renbin Liu, Susan Varghese, Samuel D. Rabkin
Journal: Cancer Research (2005)

Abstract Oncolytic herpes simplex virus vectors are a promising strategy for cancer therapy, as direct cytotoxic agents, inducers of antitumor immune responses, and as expressers of anticancer genes. Progress is dependent upon representative preclinical models to evaluate therapy. In this study, two families of oncolytic herpes simplex virus vectors (G207 and NV1020 series) that have been in clinical trials were examined for the treatment of breast cancer, using the C3(1)/T-Ag transgenic mouse model. Female mice spontaneously develop mammary carcinomas, and the C3(1)/T-Ag–derived tumor cell line M6c forms implantable tumors. Both in vitro and in vivo, G47Δ, derived from G207 by deletion of ICP47 and the US11 promoter, was more efficacious than G207. Whereas NV1023, derived from NV1020 by deletion of ICP47 and insertion of LacZ, was as cytotoxic to M6c cells in vitro as G47Δ, it did not inhibit the growth of s.c. M6c tumors but did extend the survival of intracerebral tumor bearing mice. In contrast, NV1042, NV1023 expressing interleukin 12, inhibited s.c. M6c tumor growth to a similar extent as G47Δ, but was less effective than NV1023 in intracerebral tumors. In the spontaneously arising mammary tumor model, when only the first arising tumor per mouse was treated, G47Δ inhibited the growth of a subset of tumors, and when all tumors were treated, G47Δ significantly delayed tumor progression. When the first mammary tumor was treated and the remaining mammary glands removed, NV1042 was more efficacious than G47Δ at inhibiting the growth and progression of injected tumors.
Examination of the Appendix at Laparotomy as a Diagnostic Clue in Cystic Fibrosis
Authors: Harry Shwachman, Douglas Holsclaw
Journal: New England Journal of Medicine (1972)

RECURRENT abdominal pain in childhood, with or without an abdominal mass in the right lower quadrant, often leads to the diagnosis of "chronic appendicitis" and results in an exploratory surgical procedure. An appendectomy is usually performed even though the appendix may appear grossly normal. We have seen 14 patients with recurrent abdominal pain who have undergone laparotomy and appendectomy and were subsequently found to have cystic fibrosis.The diagnosis of cystic fibrosis may be made on the basis of the histologic appearance of the appendix. The astute pathologist may recognize the increased activity of the mucus-secreting cells with wide gaping . . .
ZOOLOGY IN THE MEDICAL SCHOOL CURRICULUM.
Authors: CH. WARDELL STILES
Journal: JAMA (1901)

Let it be admitted from the start that this paper is written from the standpoint of a zoologist, hence that it is not entirely free from the charge of being a biased statement; let it also be admitted that the medical school curriculum is already full to overflowing; further, that it is not the function of a medical faculty to give to a man a general education, but rather to teach him to diagnose diseases and prescribe treatment. In order to avoid misunderstanding, the writer makes these admissions at the outset; yet he nevertheless contends that zoology should have its place in the medical curriculum, just as much as should chemistry and botany. It is not contended that elementary or general zoology should be taught, any more than it would be contended by a chemist or by a botanist that elementary or general chemistry or botany has an inherent right
Pleural Effusion in Toxic Shock Syndrome
Authors: STEPHEN L. DEMETER
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 July 1982Pleural Effusion in Toxic Shock SyndromeSTEPHEN L. DEMETER, M.D., CHARLES FUENNING, M.D., JEFFREY J. KLEIN, M.D.STEPHEN L. DEMETER, M.D.Search for more papers by this author, CHARLES FUENNING, M.D.Search for more papers by this author, JEFFREY J. KLEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-1-148_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Todd and associates (1) first described the toxic shock syndrome in 1978. Since then, numerous cases have been reported that have refined our understanding of the clinical, bacteriologie, and toxicologic basis of this disease. Pulmonary findings in this syndrome include tachypnea, hypoxemia, and radiographic findings consistent with the adult respiratory distress syndrome. We recently cared for a patient with typical toxic shock syndrome with acute respiratory distress syndrome and bilateral pleural effusions.A previously healthy, 20-year-old white woman had sudden onset of fever, chills, myalgias, and headache on the fifth day of menstruation. Within 12 hours she...References1. TODDFISHAUTKAPRALWELCH JMFT. Toxic shock syndrome associated with phage-group-1 staphylococci. Lancet. 1978;2:1116-8. CrossrefMedlineGoogle Scholar2. RICHMOND J. Advisory on toxic shock syndrome. FDA Drug Bill. 1980;July:10-11. Google Scholar3. CHESNEYDAVISPURDYWANDCHESNEY PJWPR. Clinical manifestations of toxic shock syndrome. JAMA. 1971;246:741-8. CrossrefGoogle Scholar4. MCKENNAMEADOWSBREWERWILSONPERRAULT UJNWJ. Toxic shock syndrome, a newly recognized entity. Mayo Clin Proc. 1980;55:663-72. MedlineGoogle Scholar5. FISHERGOODPASTUREPETERIAVOTH RHJD. Toxic shock syndrome in menstruating women. Ann Intern Med. 1981;94:156-63. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Northeastern Ohio Universities College of Medicine St. Thomas Hospital Medical Center Akron, OH 44310 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byToxic Shock SyndromesToxic Shock SyndromesAnimal Studies of Toxic Shock Syndrome 1 July 1982Volume 97, Issue 1Page: 148-149KeywordsAcute respiratory distress syndromeFeversHeadachesHypoxiaMyalgiaPleural effusionTachypneaToxic shock syndromeVentilators ePublished: 1 December 2008 Issue Published: 1 July 1982 PDF downloadLoading ...
BMA meeting: Doctors call for Royal Commission on copayments
Authors: Z. Kmietowicz
Journal: BMJ (2008)

Doctors at the BMA’s annual representatives’ meeting expressed their support for allowing patients to pay for treatments that the NHS does not provide without losing their right to further NHS care.

However, they stopped short of recommending a swift introduction of the system of copayments to run alongside NHS provided care, calling first for a Royal Commission to review the implications and possible alternatives.

The question of whether to permit copayments produced the most stormy debate and procedurally difficult motion of the meeting.

Those speaking against allowing copayments saw giving permission to fund non-NHS treatments as a “slippery slope” towards privatisation and exploitation of the public by the drug industry. And both sides cited the founding principles of the NHS as a reason to allow and reject payments for extra treatments.

The Department of Health in England has already asked Mike Richards, the cancer tsar, to review the …
Giant Fetal Magnetocardiogram P Waves in Congenital Atrioventricular Block
Authors: Zhimin Li, Janette F. Strasburger, Bettina F. Cuneo, Nina L. Gotteiner, Ronald T. Wakai
Journal: Circulation (2004)

Cardiogram signal amplitude is a key index of hypertrophy but has not been investigated extensively in utero. In this study, magnetocardiography was used to assess P and QRS amplitude in normal subjects and subjects with fetal arrhythmia.The study cohort consisted of 68 normal fetuses and 25 with various arrhythmias: 9 reentrant supraventricular tachycardia (SVT), 2 ventricular tachycardia (VT), 2 sinus tachycardia, 2 blocked atrial bigeminy, 2 congenital second-degree atrioventricular (AV) block, and 8 congenital complete AV block. Subjects with congenital AV block, all presenting with bradycardia, showed large QRS amplitude, exceedingly large P-wave amplitude, and long P-wave duration. The 2 subjects with VT, both with poor ventricular function, also exhibited large P waves. SVT was associated with only moderate signal amplitude elevation.The data imply that AV block in utero is accompanied by hypertrophy, which is more pronounced for the atria than the ventricles. We hypothesize that the hypertrophy results from a compensatory response associated with regulation of cardiac output and is likely to be observable in other arrhythmias and disease states. Magnetocardiography may be more sensitive than fetal echocardiography for detection of atrial hypertrophy in utero.
1213 A HIGHLY POTENT HCV NS5A INHIBITOR EDP-239 WITH FAVORABLE PRECLINICAL PHARMACOKINETICS
Authors: L.J. Jiang, S. Liu, T. Phan, C. Owens, B. Brasher, A. Polemeropoulos, X. Luo, K. Hoang, M. Wang, X. Peng, H. Cao, Y. Qiu, Y.S. Or
Journal: Journal of Hepatology (2011)
Idiopathic or Hypercatabolic Hypoproteinaemia
Authors: M. Schwartz, B. Thomsen
Journal: BMJ (1957)

or Relapsed Depressed .. 2 0 11 1 14 Manic 5* 0 2 -7 * One relapsed and was given a second course of reserpine.TABLE IVa.-Response of Patients of Group 5-Acute Schizophrenia Improhed Improved Relapsed Untraced Total 15* 2* 4 -21 * One relapsed and was given a further course of reserpine.It will be seen that the results confirm in a general way the trends of the initial assessment and encourage us to continue trial of this method of treatment.A further year's experience suggests that smaller doses may give similar results with less distressing side-effects.At present an intramuscular dosage of 10 mg.daily is the exception rather than the rule.Our usual maximum dosage is 3 mg.orally and 5 mg.intramuscularly daily.We hope to publish a further paper on a larger series with a detailed analysis of the factors influencing good or bad response, the relapse rate, and the incidence of depression.
Treatment of Primary Cutaneous Melanoma
Authors: Matthew H. Kanzler
Journal: JAMA (2001)

ITH A LACK OF SCIENTIFIC data, standard of care for treatment of patients with melanoma at the beginning of the 20th century called for extensive mutilating surgery and/or local amputation of involved body areas. In the mid1900s, aggressive lymph node dissections were popular in an attempt to control metastatic disease despite the lack of scientific data that such procedures did, indeed, affect the survival of patients with melanoma. The treatment of melanoma has changed significantly in the intervening years, and can now be guided by data regarding clinical outcomes. The purpose of this review is to present clinicians with an evidence-based summary of the current literature regarding therapy for primary cutaneous melanoma. Surgical Margins
Studies of the Antiadrenergic Effects of Nitroglycerin on the Dog Heart
Authors: RICHARD W. ECKSTEIN, WILLIAM B. NEWBERRY, JAMES A. MCEACHEN, GEORGE SMITH
Journal: Circulation (1951)

Using anesthetized dogs, the possible antiadrenergic effects of nitroglycerin upon the myocardium were studied. Observations were made upon changes in heart rate, myocardial oxygen consumption, systolic vigor, and the electrocardiograms. Data are presented showing the effects of nitroglycerin and adrenergic agents when given separately and in combination. Results indicate that in dogs, nitroglycerin produces no antiadrenergic effects on the myocardium. The suggestion is made that the T wave changes seen after adrenergic stimulation in dogs may not be due to anoxia.
Current Emergency Diagnosis and Treatment
Authors: Vincent B. Scott
Journal: JAMA (1986)

<i>Current Emergency Diagnosis and Treatment</i>is a practical text, concisely organized and easily readable, with many helpful algorithms and illustrations. No space is wasted, as the inside front and back covers are printed with useful tables. There are 45 chapters; on the first page of each is a detailed table of contents, which facilitates quick reference. Clinical problems are discussed in a structured format of diagnosis, treatment, and disposition. Finding information in the text is simple; the major problem, however, is that there is not enough information to find. The preface does warn the prospective reader that the text is a "practical orientation" to emergency medicine. Furthermore, the reader is told that emphasis is placed on making rapid diagnoses and combining evaluation with treatment. Other emergency medicine texts have successfully combined diagnosis and treatment with basic science and pathophysiology, offering the serious student and practitioners of emergency medicine excellent resource
Playing God in the Nursery
Authors: Joan E. Hodgman
Journal: JAMA (1985)

This excellent book is a clear and well-researched presentation of the difficult decisions required in the care of the very immature or handicapped infant. The effects of complex medical technology on all of the involved parties, including the patient, are discussed in a manner recognizable to physicians. The ethical and moral issues are carefully delineated. The presentation of the needs and responsibilities of the parents is particularly well done. Legal issues are clarified by discussion of the implications of the various court decisions in the field. Societal effects of high-risk infant care are included. All individuals who are involved in decisions for seriously disabled infants should benefit by reading this book. This includes physicians, nurses, hospital staff and administrators, lawyers, judges, trustees of hospitals, and politicians. Since the issues presented concern all of our society, any literate person should find this book of interest. Fortunately, it is well written and
ALLOGENEIC CARDIAC STEM CELL ADMINISTRATION FOR ACUTE MYOCARDIAL INFARCTION. A TIMING EXPERIMENTAL STUDY IN SWINE
Authors: Veronica Crisostomo, Claudia Baez-Diaz, Juan Maestre, Monica Garcia-Lindo, Fei Sun, Javier G Casado, Luis Rodriguez-Borlado, Jose Luis Abad, Francisco Miguel Sanchez-Margallo
Journal: Journal of the American College of Cardiology (2014)
Coronary expression of heat shock protein 60 and serum antibody levels in patients with acute coronary syndrome
Authors: Ryu Shutta, Shiro Hoshida, Tamaki Itakura, Shinichiro Suna, Masayuki Taniike, Yasuyuki Egami, Kenjiro Tanaka, Takayoshi Adachi, Masami Nishino, Hideo Tanahashi, Jun Tanouchi, Yoshio Yamada
Journal: Journal of the American College of Cardiology (2003)
Bovine Somatotropin Supplementation of Dairy Cows
Authors: William H. Daughaday
Journal: JAMA (1990)

Complex, biologically active proteins (eg, enzymes and hormones) can be manufactured safely and cost-effectively through applications of biotechnology. Some of these proteins (eg, human insulin, human somatotropin, rennet for cheese manufacture) are currently approved for medical or food processing applications. Bovine somatotropin (bST) for lactating dairy cattle is another product that can be produced via biotechnology and may allow dairy farmers to produce milk at a lower cost. In 1985, based on an evaluation of toxicological data, the Food and Drug Administration concluded that milk and meat from bST-supplemented cows was safe and wholesome. The Food and Drug Administration has authorized the use of milk and meat from bST-supplemented cows in the commercial food supply. Its evaluation of the impact of bST supplementation on the long-term health of dairy cattle is near completion, and bST may be approved for commercial use in early 1991.
France prepares for more cases of vCJD
Authors: A. Dorozynski
Journal: BMJ (2000)

France can expect many cases of variant Creutzfeldt-Jakob disease (vCJD), the country's health minister, Dominique Gillot, has warned. Although only three confirmed cases of the disease have emerged in France, Ms Gillot admitted that many more could follow. “With the rising number of cases of mad cow disease, it is highly probable that we will have several dozen cases [of vCJD],” the minister told the Parisien-Aujourd'hui newspaper.

President Jacques Chirac has urged his government to ban without delay the use of meat and bone meal in any animal feeds and to move towards systematic screening of cattle for bovine spongiform encephalopathy (BSE). This would mean …
Reply to S. Rana
Authors: M. Bellutti, K. Mönkemüller, L. Fry, F. Dombrowski, P. Malfertheiner
Journal: Endoscopy (2008)

We appreciate the comments of Rana et al. and share their interest in this novel topic. As they mention, often multiple white or yellow plaques are found in patients undergoing capsule endoscopy and/or double-balloon enteroscopy of the small bowel for a broad range of indications. A recent study by Fenkel et al. confirms the findings of Rana et al. In their retrospective analysis of all capsule endoscopy studies performed at an urban academic medical center during a 2-year period, the presence of lymphangiectasias was evaluated and an overall prevalence of 22.9 % determined [1]. In a statistical evaluation by logistic regression analysis Fenkel et al. established a significant association of this finding with African-American ethnicity. The clinical significance of this finding so far remains unknown.
Operation for the 'Solution' of Cataract, Commonly Called the Needle-Operation: Being Remarks in the Course of Clinical Instruction at the Central London Ophthalmic Hospital
Authors: H. Walton
Journal: BMJ (1862)

would be fever, which was in nothing different from the dominant epidemic.And when it had continued for a few days, and been regarded as the epidemic itself, and nothing more, Erysipelas would be added to it, and be, as it were, among its accidents ; and no other treatment would be required of the whole disease than if Erysipelas had formed no part of it, and no treatment of the Erysipelas, but what was included in the treatment of the whole disease.Perhaps Erysipelas may serve for the most signal example of all that is most mutable in diseases, from whatever point of view you regard them.If you want the best representative of all that the dif- ferent constitutions of men can do in diversifying the aspect of diseases, you will find it in Erysipelas.If of what times and places can do, you have it in Ery- sipelas.If of how opposite remedies can save life and restore to health from the same diseases, accord- ing to times, places, and men, you have it in Erysipelas.Origrina Communifatdirs.
Differences in maximum heart rates in distance runners during training, competition and laboratory testing
Authors: Ina Shaw
Journal: British Journal of Sports Medicine (2010)

Successful performance in aerobic distance running is dependant on the athlete's ability to cover a fixed distance in the shortest time possible. An effective distance runner's programme must include an exercise prescription specifically developed for the individual athlete. In this regard, a percentage of either measured or predicted maximum heart rate is commonly used to prescribe and measure exercise intensity. However, maximum heart rate in athletes may be greater during competition or training than during laboratory exercise testing. Therefore, it is essential to determine if endurance-trained runners train and compete at or above laboratory measures of ‘maximum’ heart rate. Research indicates that long distance runners attain higher maximal heart rates in a field or competition setting than in a laboratory setting and as such, distance event runners' exercise intensities should not be based on laboratory assessment of maximum heart rate, but instead on maximum heart rate obtained either during training or during competition.
Bacteria-Eradicating Therapy With Doxycycline in Ocular Adnexal MALT Lymphoma: A Multicenter Prospective Trial
Authors: Andrés J. M. Ferreri, Maurilio Ponzoni, Massimo Guidoboni, Antonio Giordano Resti, Letterio S. Politi, Sergio Cortelazzo, Judit Demeter, Francesco Zallio, Angelo Palmas, Giuliana Muti, Giuseppina P. Dognini, Elisa Pasini, Antonia Anna Lettini, Federico Sacchetti, Carlo De Conciliis, Claudio Doglioni, Riccardo Dolcetti
Journal: JNCI Journal of the National Cancer Institute (2006)

Background: An association between ocular adnexal MALT lymphoma (OAL) and Chlamydia psittaci ( Cp ) infection has been proposed, and recent reports suggest that doxycycline treatment causes tumor regression in patients with Cp -related OAL. The effectiveness of doxycycline treatment in Cp -negative OAL has not been tested. Methods: In a prospective trial, 27 OAL patients (15 newly diagnosed and 12 having experienced relapse) were given a 3-week course of doxycycline therapy. Objective lymphoma response was assessed by computerized tomography scans or magnetic resonance imaging at 1, 3, and 6 months after the conclusion of therapy and every 6 months during follow-up. Cp infection in patients was determined by touchdown enzyme time-release polymerase chain reaction (TETR-PCR). Statistical tests were two-sided. Results: Eleven patients were Cp DNA–positive and 16 were Cp DNA negative. Doxycycline was well tolerated. At a median follow-up of 14 months, lymphoma regression was complete in six patients, and a partial response (≥50% reduction of all measurable lesions) was observed in seven patients (overall response rate [complete and partial responses] = 48%). Lymphoma regression was observed in both Cp DNA–positive patients (seven of 11 experienced regression) and Cp DNA–negative patients (six of 16 experienced regression) (64% versus 38%; P = .25, Fisher's exact test). The three patients with regional lymphadenopathies and three of the five patients with bilateral disease achieved objective response. In relapsed patients, response was observed both in previously irradiated and nonirradiated patients. The 2-year failure-free survival rate among the doxycycline-treated patients was 66% (95% confidence interval = 54 to 78), and 20 of the 27 patients were progression free. Conclusions: Doxycycline is a fast, safe, and active therapy for Cp DNA–positive OAL that was effective even in patients with multiple failures involving previously irradiated areas or regional lymphadenopathies. The responses observed in PCR-negative OAL may suggest a need for development of more sensitive methods for Cp detection and investigation of the potential role of other doxycycline-sensitive bacteria.
Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors
Authors: Patrizia Barozzi, Mario Luppi, Fabio Facchetti, Cristina Mecucci, Milena Alù, Ronit Sarid, Valeria Rasini, Luisa Ravazzini, Elisa Rossi, Silvana Festa, Barbara Crescenzi, Dana G. Wolf, Thomas F. Schulz, Giuseppe Torelli
Journal: Nature Medicine (2003)