Urinary Alkaline Phosphatase and LDH Activities in the Differential Diagnosis of Renal Disease
Authors: ELIAS AMADOR
Journal: Annals of Internal Medicine (1965)

Article1 January 1965Urinary Alkaline Phosphatase and LDH Activities in the Differential Diagnosis of Renal DiseaseELIAS AMADOR, M.D., LIONEL E. DORFMAN, M.D., WARREN E. C. WACKER, M.D., F.A.C.P.ELIAS AMADOR, M.D.Search for more papers by this author, LIONEL E. DORFMAN, M.D.Search for more papers by this author, WARREN E. C. WACKER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-30 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUrinary alkaline phosphatase and lactic dehydrogenase (LDH) activity measurements provide specific and sensitive tools for the detection and diagnosis of urologic disease. Both the urinary alkaline phosphatase and LDH activities are elevated by carcinomas of the kidney (1-3), whereas, only the urinary LDH activity is elevated by localized carcinomas of the bladder. Urinary enzyme activities are elevated not only by urologic carcinomas but also by other serious parenchymal renal diseases (3, 4). Therefore, a systematic study of the diagnostic application of these activities in urinary diseases was undertaken. It soon became apparent that elevated urinary enzyme activities are the rule...References1. WACKERDORFMAN WELE: Urinary lactic dehydrogenase activity. I. Screening method for the detection of cancers of the kidneys and bladder. JAMA 181: 972, 1962. MedlineGoogle Scholar2. DORFMANAMADORWACKER LEEWE: Urinary lactic dehydrogenase activity. II. Elevated activities for the diagnosis of carcinomas of the kidney and bladder. Biochem. Clin. 2: 41, 1963. MedlineGoogle Scholar3. AMADORZIMMERMANWACKER ETSWE: Urinary alkaline phosphatase activity. I. Elevated urinary LDH and alkaline phosphatase activities for the diagnosis of renal adenocarcinomas. JAMA 185: 769, 1963. CrossrefMedlineGoogle Scholar4a. 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BRAINKAY RRHD: Kidney phosphatase. II. The enzyme in disease. Biochem. J. 21: 1104, 1927. CrossrefMedlineGoogle Scholar26. POLLAKBONTINGMUEHRCKEKARK VESLRCRM: Quantitative histochemistry of the nephron. IV. Alkaline phosphatase and lactic dehydrogenase activities in renal tubular diseases. J. Clin. Invest. 39: 1386, 1960. CrossrefMedlineGoogle Scholar27. POLLAKBONTINGMUEHRCKEKARK VESLRCRM: Quantitative histochemistry of the nephron. V. Alkaline phosphatase and lactic dehydrogenase activties in lupus nephritis. J. Clin. Invest. 39: 1394, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Biophysics Research Laboratory of the Division of Medical Biology, Department of Medicine, Harvard Medical School, and Peter Bent Brigham Hospital, Boston, Mass.This study was supported by grant A-4477, U. S. Public Health Service, Bethesda, Md.Dr. Amador is a Fellow of the Medical Foundation of Boston, Inc., Boston, Mass.; Dr. Dorfman is a F. N. G. Starr Memorial Scholar, Toronto, Canada; and Dr. Wacker is an Investigator of the Howard Hughes Medical Institute, Toronto, Canada.Requests for reprints should be addressed to Elias Amador, M.D., Peter Bent Brigham Hospital, 721 Huntington Ave., Boston, Mass. 02115. 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