tbuckley/cabot-search huggingface dataset:
Low Serum Thyroglobulin as a Clue to the Diagnosis of Thyrotoxicosis Factitia
Authors: Stefano Mariotti, Enio Martino, Cristina Cupini, Riccardo Lari, Claudio Giani, Lidio Baschieri, Aldo Pinchera
Journal: New England Journal of Medicine (1982)

SURREPTITIOUS ingestion of thyroid hormones may be responsible for thyrotoxicosis (thyrotoxicosis factitia). Identification of this condition often presents a difficult diagnostic challenge, since thyrotoxicosis factitia may be confused with other types of thyrotoxicosis associated with low radioiodine uptake.1 , 2 Serum thyroglobulin levels are elevated in many varieties of hyperthyroidism.3 4 5 6 7 8 Recently, some authors1 , 2 , 9 have suggested that low rather than elevated concentrations of circulating thyroglobulin in hyperthyroid patients may indicate the presence of thyrotoxicosis factitia.We have evaluated serum thyroglobulin levels in six patients with thyrotoxicosis factitia. In all cases serum thyroglobulin was undetectable by a sensitive immunoradiometric assay. Serial measurements in two . . .
US court rules that patients harmed by generic drugs cannot claim damages
Authors: C. Dyer
Journal: BMJ (2011)

The US Supreme Court has ruled that patients who developed side effects from a generic drug cannot sue the manufacturers for giving inadequate warnings on their labels because federal law requires the makers of generic drugs to use the same labelling as the branded version of the drug.

Gladys Mensing and Julie Demahy developed tardive dyskinesia from long term use of metoclopramide, also sold under the brand name Reglan. They were prescribed Reglan in 2001 and 2002 but their pharmacists dispensed a generic version of the drug, which is used to treat digestive tract problems.

State …
Chemical modulation of alveolar epithelial permeability.
Authors: J T Gatzy, M J Stutts
Journal: Environmental Health Perspectives (1980)

The volume and composition of fluid on the surface of the alveoli can affect alveolar ventilation, gas diffusion, and macrophage function. The passive permeability and active processes of the alveolar epithelial lining play a role in regulating surface fluid and are a potential site of damage by airborne chemicals. Like other epithelial barriers, the alveolar lining is permeable to lipophilic substances but restricts the transmural flow of small ions and hydrophilic nonelectrolytes (equivalent pore radius ca. 0.5-1.5 nm). The mammalian fetal lung and alveolar sacs of the adult bullfrog secrete Cl- and K+ into the airspace. Secretion by the fetal lung ceases at birth. Many environmental agents increase the permeability of the capillary endothelium and/or respiratory epithelium and induce pulmonary edema. Studies with bullfrog alveolar sacs have demonstrated that selective effects may or may not be followed by general derangement of the epithelial barrier. Exposure of the luminal surface to HgCl2 (10(-6) to 10(-4) M) induces a selective increase in Cl- secretion that is followed by a fall in transport and a general increase in ion permeation. CdCl2 (10(-5) to 10(-3) M) depresses ciliomotion on cells on the trabecula of the alveolus but does not affect Cl- secretion or transepithelial conductance. HNO3, like other mineral acids, increases conductance and the radii or pores in the barrier, whereas NaNO3 selectively inhibits Cl- secretion. Amphotericin B(10(7) to 10(-5) MJ) induces K+ secretion into the lumen of both bullfrog and rat lung. We conclude that environmental agents induce changes in epithelial function that may compromise the lung's ability to regulate respiratory fluid without destroying the characteristic permeability of the epithelial lining.
Evaluation of a new flexible fiber CO<sub>2</sub>laser for gastrointestinal cutting: NOTES and mucosectomy in a porcine model
Authors: S. Anandasabapathy, D. Maru, S. Klumpp, R. Uthamanthil, A. Borne, M. Bhutani
Journal: Endoscopy (2008)

The CO2 laser is one of the most widely used surgical tools in otolaryngology, offering precise cutting, hemostasis, predictable penetration depth, and minimal collateral damage, due to efficient absorption of CO2 laser energy by tissue water. Endoscopic use was previously limited by lack of an efficient, flexible delivery system. In 2002, Fink et al. described a hollow-core photonic band-gap fiber created with multilayered dielectric mirrors [1]. The fiber core acts as a channel for both helium flow (3 l/minute) and beam delivery, and allows improved power output. Although the precision and safety of the device have been described in the larynx and airway [2], its performance in the gastrointestinal tract has not been described. In a nonsurvival porcine model, we evaluated the performance of the flexible-fiber CO2 laser in two novel endoscopic applications: mucosectomy and natural orifice transluminal surgery (NOTES). Indeed, the hemostatic abilities of the laser and the established safety of CO2 in the peritoneal cavity make it ideal for these applications.
Therapeutic Uses of Inorganic Nitrite and Nitrate
Authors: Anthony R. Butler, Martin Feelisch
Journal: Circulation (2008)

Potential carcinogenic effects, blue baby syndrome, and occasional intoxications caused by nitrite, as well as the suspected health risks related to fertilizer overuse, contributed to the negative image that inorganic nitrite and nitrate have had for decades. Recent experimental studies related to the molecular interaction between nitrite and heme proteins in blood and tissues, the potential role of nitrite in hypoxic vasodilatation, and an unexpected protective action of nitrite against ischemia/reperfusion injury, however, paint a different picture and have led to a renewed interest in the physiological and pharmacological properties of nitrite and nitrate. The range of effects reported suggests that these simple oxyanions of nitrogen have a much richer profile of biological actions than hitherto assumed, and several efforts are currently underway to investigate possible beneficial effects in the clinical arena. We provide here a brief historical account of the medical uses of nitrite and nitrate over the centuries that may serve as a basis for a careful reassessment of the health implications of their exposure and intake and may inform investigations into their therapeutic potential in the future.
Control of vaccinia virus skin lesions by long-term-maintained IFN-γ+TNF-α+ effector/memory CD4+ lymphocytes in humans
Authors: Bénédicte Puissant-Lubrano, Philippe Bossi, Frederick Gay, Jean-Marc Crance, Olivia Bonduelle, Daniel Garin, François Bricaire, Brigitte Autran, Behazine Combadière
Journal: Journal of Clinical Investigation (2010)

Vaccinia virus (VV) vaccination is used to immunize against smallpox and historically was considered to have been successful if a skin lesion formed at the vaccination site. While antibody responses have been widely proposed as a correlate of efficacy and protection in humans, the role of cellular and humoral immunity in VV-associated skin lesion formation was unknown. We therefore investigated whether long-term residual humoral and cellular immune memory to VV, persisting 30 years after vaccination, could control VV-induced skin lesion in revaccinated individuals. Here, we have shown that residual VV-specific IFN-gamma+TNF-alpha+ or IFN-gamma+IL-2+ CD4+ lymphocytes but not CD8+ effector/memory lymphocytes expressing a skin-homing marker are inversely associated with the size of the skin lesion formed in response to revaccination. Indeed, high numbers of residual effector T cells were associated with lower VV skin lesion size after revaccination. In contrast, long-term residual VV-specific neutralizing antibody (NAbs) titers did not affect skin lesion formation. However, the size of the skin lesion strongly correlated with high levels of NAbs boosted after revaccination. These findings demonstrate a potential role for VV-specific CD4+ responses at the site of VV-associated skin lesion, thereby providing new insight into immune responses at these sites and potentially contributing to the development of new approaches to measure the efficacy of VV vaccination.
The Natural History and Progress in Treatment of Congenital Heart Defects
Authors: Mary Allen Engle
Journal: JAMA (1972)

To review this book is to remember with pleasure an excellent conference, well-planned and carried out, to bring up to date the accumulated knowledge of about 20 years of medical and surgical experiences with the common forms of congenital heart disease. Experts from Canada, the United States, Mexico, the United Kingdom, and the Netherlands summarized and illustrated their experience and presented recommendations. All that is missing in these printed pages is the cordiality and informality of discussions that followed the presentations and continued as small groups gathered and exchanged ideas. The first topic concerned the natural history of the most common malformation, ventricular septal defect (VSD). The experience of the host group from Hospital for Sick Children in Toronto set the high standard for the rest of the subjects in a critical analysis of 1,500 cases of isolated VSD under long-term follow-up. Selection of cases with large VSD for surgery
1023 HEPATOCELLULAR CARCINOMA IN THE NETHERLANDS: CHANGES IN INCIDENCE, TREATMENT AND SURVIVAL DURING THE LAST TWO DECADES
Authors: C.D.M. Witjes, S.A.W. van den Akker, O. Visser, H.E. Karim-Kos, E. de Vries, J.N.M. Ijzermans, R.A. de Man, J.-W. Coebergh, C. Verhoef
Journal: Journal of Hepatology (2011)
T cell receptor expression in Sjogren's syndrome.
Authors: A Zumla, M Mathur, J Stewart, L Wilkinson, D Isenberg
Journal: Annals of the Rheumatic Diseases (1991)

T lymphocytes expressing the gamma/delta T cell receptor and B lymphocytes expressing CD5 are known to occur in expanded numbers in the peripheral blood of patients with primary Sjögren9s syndrome. The cellular infiltrates for the surface phenotypic markers for alpha/beta and gamma/delta T cell receptors, CD4, CD8, CD45, and CD5 were examined in lip biopsy specimens from two patients with primary Sjögren9s syndrome, six with secondary Sjögren9s syndrome, and seven healthy controls. Most of the Sjögren9s lip biopsy cellular infiltrates were T lymphocytes of the CD4 subset expressing the alpha/beta T cell receptor (mean 70%). The low prevalence of gamma/delta T cell receptor bearing cells in lip biopsy specimens is maintained in Sjögren9s syndrome (mean 1.5%), and thus it seems unlikely that these lymphocytes bearing the gamma/delta T cell receptor have a major role in the immunopathology of Sjögren9s syndrome. Over 70% of cells within the lesional infiltrate of primary and secondary Sjögren9s syndrome expressed the CD5 and CD45 cell surface molecules.
The Mechanics of Left Ventricular Contraction in Acute Experimental Cardiac Failure*
Authors: John Ross, James W. Covell, Edmund H. Sonnenblick
Journal: Journal of Clinical Investigation (1967)

The effects of acute cardiac failure induced by pentobarbital or pronethalol on the basic mechanical properties of the intact left ventricle were examined in the dog, and the influence on auxotonic and isovolumic contractions of the increase in end-diastolic volume that usually accompanies cardiac failure was assessed. The right heart bypass preparation was employed, and isovolumic beats were induced by sudden balloon occlusion of the aortic root. The ventricular pressure-volume curve was determined directly, and the mechanical responses of the myocardial fibers and contractile elements were calculated.
ECHO-DERIVED ASSESSMENT OF PULSATILITY DIVERGES FROM PUMP-DERIVED ASSESSMENT, AND DEFINES SERIOUS ADVERSE EVENTS LATE AFTER CONTINUOUS FLOW LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION
Authors: Jennifer Goerbig, Guha Ashrith, Wassef Karrowni, Frances L. Johnson, Robert M. Weiss
Journal: Journal of the American College of Cardiology (2010)
Surface Potentials From the Region of the Atrioventricular Node and Their Relation to Dual Pathway Electrophysiology
Authors: Todor N. Mazgalev, Patrick J. Tchou
Journal: Circulation (2000)

Background —Clinical applications of the principles of dual atrioventricular nodal (AVN) electrophysiology in the treatment of AVN reentrant tachycardias rely on empirical findings, such as discontinued conduction curves or the presence of specific catheter-recorded signals. However, neither the shape of the conduction curve nor the surface electrograms have been validated as functionally related to the presence of slow or fast wavefronts. Methods and Results —We performed in vitro studies using 10 rabbit atrial-AVN preparations. A bipolar roving electrode was used to explore the endocardial surface of the triangle of Koch during programmed electrical stimulation. Microelectrodes were impaled in AVN cells to correlate surface and intracellular responses. In 7 preparations, a specific area near the compact cell region produced surface electrograms that were dissociated in 2 distinct components, with progressive shortening of prematurity. Similar dissociation was demonstrated during Wenckebach periodicity and increased vagal tone. Cellular recordings supported the presence of early (“fast”) and late (“slow”) wavefronts, with different refractory properties. Although the fast-slow transition was a basis for discontinued propagation, the AVN conduction curves were smooth in the majority of cases. Conclusions —Exploration of the triangle of Koch during programmed pacing reveals the presence of dual-wavefront surface potentials. Clinical confirmation of these AVN potentials could provide a new, sensitive tool in defining dual AVN electrophysiology.
Seven-year median time to progression with thalidomide for smoldering myeloma: partial response identifies subset requiring earlier salvage therapy for symptomatic disease
Authors: Bart Barlogie, Frits van Rhee, John D. Shaughnessy, Joshua Epstein, Shmuel Yaccoby, Mauricio Pineda-Roman, Klaus Hollmig, Yazan Alsayed, Antje Hoering, Jackie Szymonifka, Elias Anaissie, Nathan Petty, Naveen S. Kumar, Geetika Srivastava, Bonnie Jenkins, John Crowley, Jerome B. Zeldis
Journal: Blood (2008)
Tanz in der Therapie Schizophrener
Authors: W. Blankenburg
Journal: Psychotherapy and Psychosomatics (1969)

Research Articles| February 12 2010 Tanz in der Therapie Schizophrener: Ein Beitrag zu den Beziehungen zwischen Manieriertheit und Manierismus Subject Area: Psychiatry and Psychology W. Blankenburg W. Blankenburg Psychiatrische und Nervenklinik der Universität Freiburg i. Br. (ehem. Direktor: Prof. Dr. H. Ruffin) und Psychiatrische und Neurologische Klinik der Universität Heidelberg (Direktor: Prof. Dr. W. v. Baeyer) Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1969) 17 (5-6): 336–342. https://doi.org/10.1159/000286048 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation W. Blankenburg; Tanz in der Therapie Schizophrener: Ein Beitrag zu den Beziehungen zwischen Manieriertheit und Manierismus. Psychother Psychosom 31 December 1969; 17 (5-6): 336–342. https://doi.org/10.1159/000286048 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1969Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
The Course in Idiopathic Hypertrophic Muscular Subaortic Stenosis
Authors: BRENT M. PARKER
Journal: Annals of Internal Medicine (1969)

Eighteen patients with idiopathic hypertrophic muscular subarotic stenosis (IHSS) have been followed for an average period of 4 years. During follow-up there has been improvement or no change in 17 patients. Two patients have improved with propranolol. No patient has had surgery, and none has died. This result is contrasted with a 19% mortality in reported surgical cases. Some of the surgical survivors have potentially serious complications, and follow-up data are sparse. The results of this study suggest that IHSS is a disease of slow progression in most patients and that surgery should be reserved for those patients who have disabling symptoms that do not respond to medical therapy.
MITRAL STENOSIS, AURICULAR FIBRILLATION AND THE ACTION OF DIGITALIS
Authors: C. H. Cattle
Journal: BMJ (1921)

52r~~Ĩ n recent years, with the increase of bone grafting, par- ticularly as the result of the pioneer work of Albee, grafts and other metlhods of bony fixation have been employed for the fixation and prevention of deformity of the spine in these cases.Unquestionably this is a justifiable pro- cedure in selected cases, but many cases are not severe enough, while others are so severe and incorrectible, or are so hopelessly crippled generally, that the operation is unjustifiable.A case with obliquity of the pelvis and lumbar curve due to paralysis of the psoas or abdominal and lumbar muscles on one side, seems to me one in whicl operative fixation of the spine is worthy of serious con- sideration in the absence of any contraindications.Again, some severe " c " curves which are seen before fixation of the deformity to any great extent has occurred should also be treated by gradual correction as far as possible, with a view to eventual fixation by a bone graft.More is being done along thiese lines in America than in this country, by AlbeeI6 and Mackenzie Forbes17 among others.
Exposure to phorbol diester (TPA) in vitro as an aid in the classification of blasts in human myelogenous and lymphoid leukemias: In vitro differentiation, growth patterns, and ultrastructural observations
Authors: Aaron Polliack, Rachael Leizerowitz, Aviva Korkesh, Dorit Gurfel, Haim Gamliel, Uri Galili
Journal: American Journal of Hematology (1982)

Abstract Leukemic cells from the peripheral blood of 52 patients with acute and chronic leukemias were incubated with 12‐0‐tetradecanoyl phorbol ester (TPA). Thirty‐one cases of lymphocytic leukemia (18 cases of acute lymphoblastic and 13 cases of chronic lymphocytic leukemia), 13 cases of acute nonlymphoblastic (myelo or myelomonoblastic) leukemia, and eight cases of blastic crisis of CGL (seven cases of predominantly myeloblastic crisis, and one case of lymphoblastic crisis) were studied. In all cases of lymphoid leukemia, cells formed clumps or aggregates after exposure to TPA, while in all cases of myeloid leukemia cells became adherent to the substrate. Seven of the eight cases of blastic crisis of CGL were predominantly myeloid in type and cells adhered to the substrate, while in a single case of lymphoid crisis in CGL cells formed clumps after TPA exposure. Functional, cytochemical, and ultrastructural studies showed altered cell differentiation and continuing in vitro maturation of leukemic cells after exposure to TPA. In the light of the above results, it is concluded that this simple test employing TPA exposure in vitro serves as a reliable means of distinguishing blasts from different origins in human leukemias.
Pharyngeal and Oesophageal Diverticula
Authors: W. Hill
Journal: BMJ (1926)

Neumann whether, in doing a modlfied radica.loperation under a local anaesthetic, it was his practice to remove the iiC'us.Professor VON NEUMANN replied that in about 80 per cent. of cases of chronic otitis the incus was disarticulated from the stapes, and in these circumstances he removed it; its removal did not adversely affect the hearing.
Poor sensitivity of multiple-gated blood-pool imaging in diagnosing left ventricular aneurysms.
Authors: A P Allen, I Peart, D N Taylor, B R Condon, B C Ogilvie, J W Frank, H Sutton, D M Ackery
Journal: BMJ (1981)

A study was carried out to determine the accuracy of multiple-gated blood-pool imaging in diagnosing left ventricular aneurysm. Fifteen patients with an aneurysm and 17 with left ventricular hypokinesia were studied by contrast ventriculography and multiple-gated blood-pool imaging. The results of blood-pool imaging were examined blind by five independent observers, the results of contrast ventriculography being used as the standard. The mean sensitivity of the procedure was 56%, the specificity 61%, and diagnostic accuracy 59%. These results indicate that contrast ventriculography remains the best method for diagnosing left ventricular aneurysms. Moreover, ventriculography provides additional information-for example, on wall thickness-not provided by multiple-gated blood-pool imaging.
Centennial Salute to Boston Medical Library
Authors: Joseph E. Garland
Journal: New England Journal of Medicine (1975)

When the pair of rented rooms of the Boston Medical Library in Hamilton Place, across from the Park Street Church, opened to members, on October 18, 1875, on the restless initiative of James Read Chadwick, under the grave aegis of Henry Ingersoll Bowditch and with the benign blessing of Oliver Wendell Holmes, they had choice of perhaps 4000 books and bound journals and 120 periodicals.This was, in fact, the second try at setting up a general medical library. Its predecessor was organized by James Jackson and John Collins Warren and friends in 1805, five years before they proposed the . . .