tbuckley/cabot-search huggingface dataset:
Integrin signaling is critical for pathological angiogenesis
Authors: Ganapati H. Mahabeleshwar, Weiyi Feng, David R. Phillips, Tatiana V. Byzova
Journal: The Journal of Experimental Medicine (2006)

The process of postnatal angiogenesis plays a crucial role in pathogenesis of numerous diseases, including but not limited to tumor growth/metastasis, diabetic retinopathy, and in tissue remodeling upon injury. However, the molecular events underlying this complex process are not well understood and numerous issues remain controversial, including the regulatory function of integrin receptors. To analyze the role of integrin phosphorylation and signaling in angiogenesis, we generated knock-in mice that express a mutant β3 integrin unable to undergo tyrosine phosphorylation. Two distinct models of pathological angiogenesis revealed that neovascularization is impaired in mutant β3 knock-in mice. In an ex vivo angiogenesis assay, mutant β3 knock-in endothelial cells did not form complete capillaries in response to vascular endothelial growth factor (VEGF) stimulation. At the cellular level, defective tyrosine phosphorylation in mutant β3 knock-in cells resulted in impaired adhesion, spreading, and migration of endothelial cells. At the molecular level, VEGF stimulated complex formation between VEGF receptor-2 and β3 integrin in wild-type but not in mutant β3 knock-in endothelial cells. Moreover, phosphorylation of VEGF receptor-2 was significantly reduced in cells expressing mutant β3 compared to wild type, leading to impaired integrin activation in these cells. These findings provide novel mechanistic insights into the role of integrin–VEGF axis in pathological angiogenesis.
London primary care trusts overspent 10 month targets by 100m
Authors: H. Vickers
Journal: BMJ (2010)

Almost all of London’s Primary Care Trusts (PCTs) spent more on acute hospital services in the first ten months of 2010 than planned, according to a survey by pressure group London Health Emergency. It says the reported excess is more than £100m (€116m; $154m) across the trusts.

Of London’s 31 PCTs, 27 declared “over performance” by hospitals on emergencies, elective cases and day cases. Published in year to date finance reports on trust websites, 21 of these PCTs gave figures for an overspend, totalling more than £100m. The largest overspend was Haringey’s, at £10.9m.

Forecasts for complete 2010 finances were mixed, with …
COMLA Chemotherapy for Lymphoma
Authors: PETER C. RAICH
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 September 1980COMLA Chemotherapy for LymphomaPETER C. RAICH, M.D.PETER C. RAICH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-3-509 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sweet and associates (1) recently reported on the usefulness of the COMLA combination chemotherapy regimen (cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine) as an alternate treatment to doxorubicin-containing programs for advanced histocytic lymphoma. We wish to report on the results with the same program in patients with diffuse histocytic and lymphocytic lymphoma and discuss our findings in light of those of Sweet and associates.Our program was initiated in 1976 (with Dr. R. Stein's assistance) by the members of the Wisconsin Hematology Study Group. An abstract of earlier results was published in the 1978 Proceedings of...References1. SWEETGOLOMBULTMANN DHJ. Cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine (COMLA) combination sequential chemotherapy for advanced diffuse histiocytic lymphoma. Ann Intern Med. 1980;92:785-90. LinkGoogle Scholar2. RAICH P Treatment of non-Hodgkin's lymphoma with the COMLA regimen. Proc Am Soc Clin Oncol. 1978;19:395. Abstract. Google Scholar3. SANTOROBONADONNABONFANTEVALAGUSSA AGVP. Noncross resistant regimens (MOPP and ABVD) vs MOPP alone in Stage IV Hodgkin's disease (HD). Proc Am Soc Clin Oncol. 1980;21:470. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PETER C. RAICH, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnalgesic Nephropathy and the Effect of Non-Steroidal Anti-Inflammatory Drugs on the KidneyDifferent Forms of Ischemic/ Toxic Acute Renal Failure in HumansUse of Drugs in Uremia and Dialysis 1 September 1980Volume 93, Issue 3Page: 509-510KeywordsChemotherapyCombination chemotherapyCyclophosphamideHematology and oncologyLymphomaMethotrexate ePublished: 1 December 2008 Issue Published: 1 September 1980 PDF downloadLoading ...
mRNA analysis in reticulocytes of subjects with Hb D, Hb Porto Alegre, Hb E, and different types of unstable hemoglobin variants
Authors: N. S. Smetanina, T.H. J. Huisman
Journal: American Journal of Hematology (1996)

Using a reverse transcription-polymerase chain reaction (RT-PCR) technique we determined the alpha 2/alpha 1, alpha/beta, and gamma/beta mRNA ratios in reticulocytes of 11 patients with seven different unstable beta chain variants, of 4 patients with two unstable alpha chain variants, in hemoglobin (Hb) D, Hb Porto Alegre, and Hb E heterozygotes, and in 8 patients with Hb X-beta 0-thalassemia (thal) (three D-beta 0-thal, one Porto Alegre = beta 0-thal, one Lulu Island-beta 0-thal, and three E-beta 0-thal). In addition, we determined the beta X/beta A mRNA ratios (X = unstable) in some Hb D heterozygotes and in 6 subjects with an unstable beta chain variant. Normal alpha/beta and beta X/beta A mRNA ratios were found in all heterozygotes tested, indicating that the respective mutations did not alter the stability of the mRNAs. The alpha/beta mRNA ratio in four Hb E heterozygotes averaged 4.21 (normal, 4.47), and that in 2 patients with Hb E-beta 0-thal and four alpha-globin genes (alpha alpha/alpha alpha) averaged a high 22.4. The gamma mRNA level in the Hb E heterozygotes was < 1% but varied greatly in patients with Hb E-beta 0-thal; the alpha/(gamma + beta) mRNA ratios in the 2 patients were 15.5 and 16.7, respectively. The large differences in alpha/beta and alpha/(gamma + beta) mRNA ratios in reticulocytes of subjects with AE and with E-beta 0-thal may be due to differences in the levels of normally-spliced beta E and abnormally-spliced beta E mRNAs. Only the latter is unstable and is preferentially produced in bone marrow and reticulocytes of Hb E-beta 0-thal patients, where it is rapidly degraded.
Physical Activity and Body Composition of Adolescent Boys
Authors: Ladislav P. Novak
Journal: JAMA (1966)

Because physical activity has a profound effect on body composition and since this statement is popular knowledge, one might expect to find numerous scientific studies of the changes which occur in body composition under the influence of physical regimen. However, an intensive search through the literature has revealed few studies on this topic, and these few have had almost exclusively adult men as subjects. As background for this examination of adolescents and the effect of physical activity on body composition, the studies involving adult subjects will be summarized.  Anthropometrical and skinfold appraisal of increased musculature or decreased subcutaneous fat tissues under the influence of various physical activities were reported by Tanner 1 and Thompson et al. 2 Densitometry was used by Behnke et al, 3 who were the first to point out, in their study of specific gravity of football players, that it may be erroneous to regard an individual
Wenckebach Periods in the Bundle Branches
Authors: MAURICIO B. ROSENBAUM, GERARDO J. NAU, RAUL J. LEVI, M. SUSANA HALPERN, MARCELO V. ELIZARI, JULIO O. LAZZARI
Journal: Circulation (1969)

Two cases of intermittent bundle-branch block in which Wenckebach periods could be directly visualized are reported. The conduction ratios were either 3:2 or 4:3, as are commonly seen in cases of the Wenckebach phenomenon of atrioventricular (A-V) conduction. Other groups of beats apparently showing 3:1 and 4:1 bundle-branch block were interpreted as indicating incompletely concealed Wenckebach periods in the bundle branches, with actual conduction ratios of 3:2 and 4:3, respectively. Three prerequisites are necessary for the occurrence of either direct or incompletely concealed Wenckebach periods in the bundle branches: (1) The opening beat should be normally conducted (in the affected bundle branch); (2) the second beat should be conducted with a delay of no more than 0.04 to 0.06 sec; (3) the damaged bundle branch should not be activated retrogradely in the closure beat. Wenckebach periods in the bundle branches may be completely concealed if the conduction delay lasts more than 0.04 to 0.06 sec in the opening beat. In cases of bilateral bundle-branch block, Wenckebach periods in the bundle branches may be indirectly visualized through changes in the A-V conduction.
Barriers to Use of Free Antiretroviral Therapy in Injection Drug Users
Authors: Steffanie A. Strathdee
Journal: JAMA (1998)

In British Columbia, human immunodeficiency virus (HIV)-infected persons eligible for antiretroviral therapy may receive it free but the extent to which HIV-infected injection drug users access it is unknown.To identify patient and physician characteristics associated with antiretroviral therapy utilization in HIV-infected injection drug users.Prospective cohort study with record linkage between survey data and data from a provincial HIV/AIDS (acquired immunodeficiency syndrome) drug treatment program.British Columbia, where antiretroviral therapies are offered free to all persons with HIV infection with CD4 cell counts less than 0.50 x 10(9)/L (500/microL) and/or HIV-1 RNA levels higher than 5000 copies/mL.A total of 177 HIV-infected injection drug users eligible for antiretroviral therapy, recruited through the prospective cohort study since May 1996.Patient use of antiretroviral drugs through the provincial drug treatment program and physician experience treating HIV infection.After a median of 11 months after first eligibility, only 71 (40%) of 177 patients had received any antiretroviral drugs, primarily double combinations (47/71 [66%]). Both patient and physician characteristics were associated with use of antiretroviral drugs. After adjusting for CD4 cell count and HIV-1 RNA level at eligibility, odds of not receiving antiretrovirals were increased more than 2-fold for females (odds ratio [OR], 2.53; 95% confidence interval [CI], 1.08-5.93) and 3-fold for those not currently enrolled in drug or alcohol treatment programs (OR, 3.49; 95% CI, 1.45-8.40). Younger drug users were less likely to receive therapy (OR, 0.47/10-y increase; 95% CI, 0.28-0.80). Those with physicians having the least experience treating persons with HIV infection were more than 5 times less likely to receive therapy (OR, 5.55; 95% CI, 2.49-12.37).Despite free antiretroviral therapy, many HIV-infected injection drug users are not receiving it. Public health efforts should target younger and female drug users, and physicians with less experience treating HIV infection.
The Drug Treatment of Depression
Authors: John M. Davis
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The exchange of letters by Callaway et all with Motto (<b>211</b>:1188, 1970) concerning the drug treatment of depression requires some comment. Callaway et al criticize Motto for stating that he is "unimpressed by what are called antidepressant drugs," that he could not find reasonable evidence of antidepressive effects, and had "yet to see a welldesigned and executed clinical investigation that demonstrates more than a mild tranquilizing benefit" from the tricyclic antidepressants. He then recommends the use of dextroamphetamine. Callaway et al point out that there has been ample demonstration of the efficacy of antidepressants and that the evidence is plentiful and accessible. They further disagree with Motto's view that amphetamines are very effective, and in fact state that there is available "literature as to their demonstrated ineffectiveness." In rebuttal Motto first quotes Cole<sup>1</sup>as stating that the place of antidepressants in the physician's armamentarium is
Rejection of bone-marrow graft by recipient-derived cytotoxic T lymphocytes against minor histocompatibility antigens
Authors: P.J. Voogt, W.E. Fibbe, W.A.F. Marijt, W.F.J. Veenhof, M. Hamilton, F.E. Zwaan, R. Willemze, J.H.F. Falkenburg, P.J. Voogt, W.A.F. Marijt, E. Goulmy, A. Brand, J.J.van Rood
Journal: The Lancet (1990)
Under a Cloud
Authors: M. Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glass Particle Contamination of Solutions
Authors: Herzl Katz
Journal: JAMA (1974)

<h3>To the Editor.—</h3> There have been multiple reports of contamination of large-volume intravenous solutions by a wide variety of particulate matter, including asbestos fibers<sup>1</sup>and rubber particles.<sup>2</sup>We have previously reported contamination of 2-ml and 5-ml ampules by grossly visible glass fragments that fall back into solution after ampules are snapped open at the color-break marking on the ampule neck.<sup>3</sup>One can presume that smaller, invisible fragments are probably also present. It is unlikely that the fragments in these small volumes can cause harm when administered intravenously, although there have been reports of pulmonary microemboli, thrombi, and granulomas after large-volume multiliter infusions. We have also noted glass fragments that have fallen into opened 20-ml and 30-ml ampules of local anesthetic solutions packaged for epidural and caudal anesthesia (Figure). It is possible that granuloma formation and foreign body reaction to these particles might occur if injected into the epidural
Appoint someone to make medical decisions if you are incapacitated, BMA says
Authors: Clare Dyer
Journal: BMJ (2007)

s health secretary, has said that some Muslim GPs may be divulging details of the sexual health of female Muslim patients to family members.Her comments drew an angry response from Muslim GPs, who said that her claims were based only on anecdotal evidence.However, Mrs Hewitt, who represents a constituency in Leicester with a large ethnic minority community, said, "I have had Muslim women give me chapter and verse on very distressing breaches of confidentiality by Muslim GPs."Some women patients in some Muslim communities are feeling they can't trust their own GP, who is from the same community and knows their extended family."If they go for particular situations, such as a sexual health problem or domestic violence, they fear they will share that information with other members of the family or community."Mrs Hewitt made her comments in an interview with the magazine for GPs Pulse (29 Mar, p 2).Vijoy Singh, chairman of the Leicestershire and Rutland local medical committee, which covers Ms Hewitt's constituency, said, "No GP would break confidentiality, because if they break it they are liable to be sued.She's out of touch."Mrs Hewitt cited a report published in November last year by the Muslim Women's Network, which was based on conversations with Muslim women throughout the country, as further evidence of her concerns.The report, She Who Disputes (www.thewnc.org.uk/pubs/shewhodisputesnov06.pdf),noted: "Health services were criticised for being insensitive and there was repeated concern that GPs from within the community could not be trusted to maintain patient confidentiality." Hewitt says some Muslim GPs breach confidentialityUK NEWS Safety agency prioritises better use of anticoagulants, p714 World NEWS drugs are as goo�� as ���� in stable coronary artery ��isease, stu��y s�o�s, p71� drugs are as goo�� as ���� in stable coronary artery ��isease, stu��y s�o�s, p71� , p71� bmj.com o�for�� ra��cliffe �ospitals tol�� to impro�e team�or� o�for�� ra��cliffe �ospitals tol�� to impro�e team�or�
Economics of dialysis.
Authors: J. Macrae, R. V. Walley, A. S. Parker
Journal: BMJ (1969)

Scrotal Carcinoma SIR,-The incidence of scrotal carcinoma in workers exposed to mineral oil has recently been highlighted by a £10,000 award by Mr. Justice Swanwick.'Local inquiries in New South Wales by management, alerted to the possibility of danger of ca-:cinogenesis, prompted me to look into the matter.In 15 years I have not seen a single case of scrotal carcinoma in New South Wales, despite the fact that many thousands of workers are exposed to mineral oils.Two large insurance companies, which together handle over 50% of the workers' compensation insurance in this State, have never seen a case of scrotal carcinoma.(Squamous carcinoma is quite a common lesion in Australia, involv- ing predominantly those sites exposed to strong sunshine.)Perhaps, in addition to pro- viding impervious aprons for workers exposed to mineral oils, a daily shower at the end of the shift should be mandatory, and underwear and overalls should be laundered frequently.This procedure is voluntarily followed by the vast majority of workers in this State.Most people would agree that scrotal carcinoma should be an entirely preventable
Allergy to Storage Mites or Cow Dander as a Cause of Rhinitis among Finnish Dairy Farmers
Authors: E. O. TERHO, K. HUSMAN, I. VOHLONEN, M. RAUTALAHTI, H. TUKIAINEN
Journal: Allergy (1985)

The role of storage mites Acarus siro, Lepidoglyphus destructor, and Tyrophagus putrescentiae, compared with that of cow dander, as a cause of allergic rhinitis was studied by nasal challenges in a population of 106 non‐smoking dairy farmers. Thirty‐six of the subjects were challenged with storage mites alone, each with only one of the three species in consecutive order, 43 with cow dander alone, and 27 with both. Thus mite challenges were performed on 63 farmers and cow dander challenges on 70. Challenges with any one of the storage mite species were positive in 18% and with cow dander in 20 % of farmers with allergic rhinitis. All challenges to asymptomatic farmers were negative. Five of the eight positive reactions to storage mites were due to Lepidoglyphus destructor, and three to Tyrophagus putrescentiae. Acarus siro was not responsible for any of the positive reactions. The results indicate that, among dairy farmers, storage mites are as common as cow dander as a cause of allergic occupational rhinitis.
Intermittent Claudication on a Venous Basis: Case Report
Authors: Morris M. Weiss
Journal: JAMA (1961)

THE FOLLOWING is a report of a case of intermittent claudication on a venous, rather than an arterial, basis. German authors<sup>1-4</sup>have described cases of "intermittent claudication" of the arm, associated with pain and swelling, due to trauma to the major venous drainage. In our patient, intermittent claudication in a leg followed iliofemoral phlebitis, and there was little or no chronic edema and no ulceration. We have been unable to find a similar case report in the American or European literature. <h3>Report of a Case</h3> The patient was a 32-year-old white housewife. Three and one-half years prior to being seen by us, when two and one-half months pregnant, she experienced pain in the left lower quadrant of the abdomen and in the left femoral triangle. This was associated with nausea and vomiting and swelling of the entire left leg. A diagnosis of left iliofemoral phlebitis and pelvic phlebitis
Intrapulmonary Segment in Anomalous Pulmonary Venous Connection
Authors: FRANCIS J. EVERHART, MICHAEL E. KORNS, KURT AMPLATZ, JESSE E. EDWARDS
Journal: Circulation (1967)

Three cases showing a large anomalous venous channel in the right lung are presented. In each case the large vein was a part of a pulmonary venous collateral system in association with anomalous pulmonary venous connection, partial in one case, and total in two. In two of the cases, each of which was an example of total anomalous pulmonary venous connection, the anomalous vein in the right lung received the entire venous system of the left lung. In the two cases with conventional roentgenograms the anomalous vein within the right lung was apparent. Its shape, in some respects, resembled that of the anomalous pulmonary vein in the scimitar syndrome. Selective pulmonary arteriography appears to offer the best means of differentiation between an anomalous vein of the type described here and that of anomalous drainage of the hypoplastic right lung to the inferior vena cava (the scimitar syndrome).
New standards in Ireland aim to improve safety and quality of health services
Authors: M. Houston
Journal: BMJ (2012)

New national standards aimed at protecting patients and radically improving health services in Ireland, and which will form the basis for future licensing of all healthcare facilities, have been launched by the Health Information and Quality Authority.1

The new standards follow a number of high profile failures in the health system, including a year long investigation into the running of Tallaght Hospital’s emergency department in Dublin after an inquest into the death of a patient who died in a corridor while waiting for a bed. It found Thomas Walsh was the victim of an abdication …
Remarks on the Influence of Obstetric Knowledge on the Mortality of Mothers in Childbed
Authors: A. W. Edis
Journal: BMJ (1878)

This is as perhaps you are aware, the method by which the University of Edinburgh succeeds in defeating that process of underbidding which would otherwise be fatal to its existence as a great school.In this way,, we might have in London, each provided with ample laboratory, museum, and assistants, two Professors of Physiology, one of Surgical Anatomy, one of Comparative Anatomy, one of Embryology, one of Botany, one of Pathological Anatomy, one of Pharmaco- logy, one of lIygiene.one of Forensic Medicine.two of Chemistry, one of Experimental Physics, and others of the History and Practice of Medicine, of Surgery, of Midwifery, and of Psychiatry.The maini- tenance of such a staff, with their laboratories and assistants, would require an endowment of (20,000 a-year, whilst jtooooo would have to be sunk in providing the necessary buildings.This proposition appears Utopian; but all I have to say further in defence of it is this, that in Berlin, Vienna, Leipzig, and other continental cities the thing is done, and on a more costly scale than I have bere suggested.When such Medical Faculties as I have sketched to you exist in Oxford and in London, England will have begun to do her duty by the great profession of medicine.Until then, we are but hangers-on of foreign nations; until then, we reap where we did not sow, we gather where we did not straw.Until that time, I earnestly beg every man who enters on a medical career to remember that he is joining the cause of a profession deprived of its heritage, and to make it his busi- ness to reinstate medicine in her seat, and to secure the restitution of her possessions.