Drug-induced Hemolytic Anemia
Authors: NANNIE K. M. DE LEEUW
Journal: Annals of Internal Medicine (1963)

Article1 April 1963Drug-induced Hemolytic AnemiaNANNIE K. M. DE LEEUW, M.D., M.SC., F.A.C.P., LORNE SHAPIRO, M.D., F.R.C.P. (C), F.A.C.P., LOUIS LOWENSTEIN, M.D., F.A.C.P.NANNIE K. M. DE LEEUW, M.D., M.SC., F.A.C.P., LORNE SHAPIRO, M.D., F.R.C.P. (C), F.A.C.P., LOUIS LOWENSTEIN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-592 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHemolytic Anemia may result from the administration of oxidant drugs, including primaquine, sulfonamides, nitrofurantoin, acetylsalicylic acid, and acetophenetidine (1-4). Recent publications have emphasized the close etiological relationship of erythrocyte glucose-6-phosphate dehydrogenase (G6PD) deficiency to this type of drug-induced hemolytic anemia (1-6). This deficiency is an inherited, sexlinked trait of incomplete dominance with variable expressivity (7, 8). It is associated with instability of reduced glutathione (GSH) in the red cell, and a slightly decreased red-cell life span (4) which is reduced further, by selective destruction of the older cells, when oxidant drugs are administered. It is believed that this red-cell defect...References1. BEUTLER E: Drug-induced hemolytic anemia (primaquine sensitivity), in The Metabolic Basis of Inherited Disease, ed. by Stanbury, J. B., Wyngaarden, J. B., and Fredrickson, D. S., The McGraw-Hill Book Company, Inc., New York, 1960, chap. 32, p. 1031. Google Scholar2. BEUTLER E: The hemolytic effect of primaquine and related compounds: a review. Blood 14: 103, 1959. CrossrefMedlineGoogle Scholar3. TARLOVBREWERCARSONALVING ARGJPEAS: Primaquine sensitivity. Arch. Intern. Med. (Chicago) 109: 209, 1962. CrossrefMedlineGoogle Scholar4. KELLERMEYERTARLOVBREWER RWARGJ: Hemolytic effect of therapeutic drugs. Clinical considerations of the primaquine-type hemolysis. JAMA 180: 388, 1962. 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