Intensive Therapy in AL Amyloidosis and Light-Chain Deposition Disease
Authors: Xavier Mariette
Journal: Annals of Internal Medicine (1995)

Letters1 October 1995Intensive Therapy in AL Amyloidosis and Light-Chain Deposition DiseaseXavier Mariette, MD, PhD, Jean-Pierre Clauvel, MD, and Jean-Claude Brouet, MD, PhDXavier Mariette, MD, PhDHopital Saint-Louis; 75010 Paris; FranceSearch for more papers by this author, Jean-Pierre Clauvel, MDHopital Saint-Louis; 75010 Paris; FranceSearch for more papers by this author, and Jean-Claude Brouet, MD, PhDHopital Saint-Louis; 75010 Paris; FranceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-7-199510010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. van Buren and colleagues [1] reported clinical remission in a patient with AL amyloidosis after intensive chemotherapy followed by syngeneic bone marrow transplantation. Light-chain deposition disease, another immunoglobulinrelated complication in multiple myeloma, usually worsens despite conventional therapy [2]. We observed a striking recovery from multiorgan failure and clearing of light-chain deposits after high-dose chemoradiotherapy supported by peripheral blood stem-cell autograft in a patient with multiple myeloma and widespread light-chain deposits.A 42-year-old man presented in April 1991 with cardiac and renal failure (creatinine level, 4 mg/dL). The patient's liver was enlarged, and the alkaline phosphatase level ...References1. van Buren M, Hen&130; RJ, Verdonck LF, Verzijlbergen FJ, Lokhorst H. Clinical remission after syngeneic bone marrow transplantation in a patient with AL amyloidosis. Ann Intern Med. 1995;122:508-10. Google Scholar2. Solomon A, Weiss DT. Ominous consequences of immunoglobulin deposition. N Engl J Med. 1993; 329:1422-3. Google Scholar3. Fermand JP, Chevret S, Ravaud P, Divine M, Leblond V, Dreyfus F, et al. High-dose chemoradiotherapy and autologous blood stem cell transplantation in multiple myeloma. Results of a phase II trial involving 63 patients. Blood. 1993; 82:2005-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hopital Saint-Louis; 75010 Paris; France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe pathogenesis of renal injury and treatment in light chain deposition diseaseTherapeutic Apheresis for Renal DisordersBiopsy-proven resolution of renal light-chain deposition disease after autologous stem cell transplantationAmyloidosis and Other Fibrillary and Monoclonal Immunoglobulin-Associated Kidney DiseasesReversal of dialysis-dependent renal failure in light-chain deposition disease by autologous peripheral blood stem cell transplantationHigh dose chemotherapy in light chain or light and heavy chain deposition diseaseLight Chain Deposition DiseaseLight chain deposition disease with renal involvement: clinical characteristics and prognostic factorsTreating primary systemic amyloidosis with stem cell transplantation: outcomes in renal amyloidosisKidney and liver involvement in monoclonal light chain disordersBlood stem cell transplantation as therapy for primary systemic amyloidosis (AL)Disappearance of nodular mesangial lesions in a patient with light chain nephropathy after long-term chemotherapyHematopoietic Cell Transplantation for Primary Systemic Amyloidosis: What Have We LearnedPrognostic factors for survival and response after high‐dose therapy and autologous stem cell transplantation in systemic AL amyloidosis: a report on 21 patientsCombined Bilateral Submandibular and Sublingual Swelling, Macroglossus, and Carpal Tunnel Syndrome Caused by Light Chain AmyloidosisBIOLOGY AND THERAPY OF IMMUNOGLOBULIN DEPOSITION DISEASES 1 October 1995Volume 123, Issue 7Page: 553KeywordsAmyloidosisBiopsyBlood cellsBone marrowChemotherapyCreatinineCyclophosphamideLiverMultiple myelomaStem cells Issue Published: 1 October 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...