tbuckley/cabot-search huggingface dataset:
Glipizide-GITS Does Not Increase the Hypoglycemic Effect of Mild Exercise During Fasting in NIDDM
Authors: Matthew C Riddle, Patricia A McDaniel, Leslie A Tive
Journal: Diabetes Care (1997)

OBJECTIVE This study compared the effect of mild exercise while fasting on plasma glucose concentrations in subjects with NIDDM treated with extended-release glipizide and subjects not taking an oral hypoglycemic agent. RESEARCH DESIGN AND METHODS Twenty-five moderately obese subjects with NIDDM were randomized to treatment with extended-release glipizide or placebo. After 9 weeks of treatment, they fasted overnight, took their study drug, omitted breakfast, and exercised on a treadmill for 90 min. Glucose, insulin, and C-peptide concentrations were measured before, during, and after exercise. RESULTS On the fasting-exercise day, fasting glucose concentrations were lower (153 vs. 241 mg/dl, P &amp;lt; 0.01) and insulin and C-peptide concentrations higher in the extended-release glipizide group. The decrement of glucose from the fasting baseline was modest and equivalent in the two groups: 17 vs. 21 mg/dl at the end of exercise and 28 vs. 27 mg/dl after 2 h of recovery. No subject had hypoglycemic symptoms. CONCLUSIONS Chronic use of extended-release glipizide does not enhance the hypoglycemic effect of fasting plus mild exercise for people with NIDDM. Routine lifestyle treatments for NIDDM may be continued during ongoing use of this agent.
Letter by Vallakati and Sharma Regarding Article, “Magnetic Resonance Imaging With 3-Dimensional Analysis of Left Ventricular Remodeling in Isolated Mitral Regurgitation: Implications Beyond Dimensions”
Authors: Ajay Vallakati, Abhishek Sharma
Journal: Circulation (2013)

We read with great interest the article by Schiros et al 1 regarding 3-dimensional analysis of left ventricular remodeling in isolated mitral regurgitation using MRI.The well-written study attempts to demonstrate that geometry-independent volume assessment may serve as a better marker for optimal timing of surgery in these patients.However, a few interesting points arise from the analysis which we feel may be pertinent.First, the study demonstrated that bullet formula underestimates end systolic left ventricular volume in the mitral regurgitation group.In light of present guidelines, which favor surgery in asymptomatic chronic mitral regurgitation with left ventricular ejection fraction <60% and end systolic dimension >40 mm, 2 it would be interesting to see whether this underestimation resulted in a significant difference between calculated (from bullet formula) and measured ejection fraction (from MRI).In fact, the authors have stated that there were few patients with calculated ejection fraction >60% in whom subsequent MRI uncovered ejection fraction <60%.Do the authors have data on these patients?Increased incidence of postoperative dysfunction in these patients would further support the authors' recommendations for superior evaluation of left ventricular geometry.Second, the effective regurgitant orifice and left atrial volume predict long-term outcomes of asymptomatic mitral regurgitation. 3,4It would be interesting to know whether quantitative estimation of mitral regurgitation and left atrial geometric analysis by MRI is predictive of long-term mortality in medically managed mitral regurgitation.
Susceptibility to multiple sclerosis associated with an immunoglobulin gamma 3 restriction fragment length polymorphism.
Authors: C N Gaiser, M J Johnson, G de Lange, L Rassenti, L L Cavalli-Sforza, L Steinman
Journal: Journal of Clinical Investigation (1987)

Susceptibility to multiple sclerosis (MS) has been linked to the immunoglobulin G (Gm) markers as well as HLA-DR genes. We have used a genomic Ig gamma 1 probe which detects polymorphisms in the gamma 1, gamma 2, gamma 3 and pseudogamma genes to identify restriction fragment length polymorphisms associated with MS. A negative association was found between a 5.9-kilobase (kb) Bst EII gamma 3 fragment and MS. Southern blot analysis of genomic DNA revealed the presence of this fragment in 84 of 140 (60.0%) controls, but in only 17 of 59 (28.8%) MS patients. The frequency of the fragment in 47 myasthenia gravis and 16 Graves' disease patients was similar to that in controls, 60.0 and 62.5%, respectively.
Implementing health care reform in US may still be difficult despite Obama win
Authors: J. H. Tanne
Journal: BMJ (2012)

President Barack Obama said in his victory speech this week, after winning a second term in the White House, that the Affordable Care Act to expand health care to about 30 million uninsured people will go forward. The act was passed in March 2010 without Republican support.1

Although widespread health insurance is now a certainty for the United States, implementing the health reform act may not be smooth and easy. It will face lawsuits from groups that object to some of its provisions and objections from states that do not want to participate in parts of health reform, such as the creation of insurance exchanges …
Incidence of incomplete stent apposition at six month follow-up in the multi center RAVEL trial
Authors: M. Degertekin, E. Regar, K. Tanabe, J.E. Sousa, A. Colombo, G. Guagliumi, J.L. Guermonprez, P. de Feyter, M.C. Morice, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2002)
Concomitant use of proton-pump inhibitors with clopidogrel may increase risk for readmission after discharge for acute MI
Authors: Christopher B. Granger
Journal: Annals of Internal Medicine (2009)

ACP Journal Club18 August 2009Concomitant use of proton-pump inhibitors with clopidogrel may increase risk for readmission after discharge for acute MIChristopher B. Granger, MDChristopher B. Granger, MDDuke Clinical Research Institute, Durham, North Carolina, USA (C.B.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-4-200908180-02013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationJuurlink DN, Gomes T, Ko DT, et al. A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ. 2009;180:713-8. https://pubmed.ncbi.nlm.nih.gov/19176635Clinical Impact RatingsGIM/FP/GP: Cardiology: Reference1 Fox KA, Mehta SR, Peters R, et al. Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial. Circulation. 2004;110:1202-8. [PMID: 15313956] Google Scholar Author, Article, and Disclosure InformationAffiliations: Duke Clinical Research Institute, Durham, North Carolina, USA (C.B.G.)This article was published at Annals.org on 4 August 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClopidogrel and proton pump inhibitors: a clinically meaningful interaction? 18 August 2009Volume 151, Issue 4Page: JC2-13KeywordsLong-term careObservational studiesPercutaneous coronary interventionVitamin E ePublished: 18 August 2009 Issue Published: 18 August 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evidence for developmental changes in sodium channel inactivation gating and sodium channel block by phenytoin in rat cardiac myocytes.
Authors: Y Q Xu, A S Pickoff, C W Clarkson
Journal: Circulation Research (1991)

The voltage-dependent properties of the voltage-activated sodium channel were studied in neonatal (1-2-day-old) and adult rat ventricular cardiac myocytes using the whole-cell variation of the patch-clamp technique (16 degrees C, [Na]i = 15 mM, [Na]o = 25 mM). The voltage dependence of the sodium conductance-membrane potential relation was similar in both neonatal and adult myocytes except for a difference in slope; the adult sodium conductance-membrane potential relation was slightly more steep. Neonatal cells also differed from adult cells by demonstrating a more negative voltage midpoint of their sodium availability curve, a slower rate of recovery from inactivation at hyperpolarized potentials, and a greater extent of slow inactivation development compared with adult cells. Phenytoin (40 microM) reduced the sodium current in a tonic and use-dependent manner in both adult and neonatal myocytes. However, phenytoin (40 microM) produced significantly more tonic block at negative holding potentials (e.g., -140 mV) in neonatal myocytes (22 +/- 5% [mean +/- SEM], n = 14) than in adult myocytes (10 +/- 2%, n = 11) (p less than 0.05). The amplitudes of use-dependent block obtained during trains of 1-second pulses to -20 mV were also significantly greater in neonatal myocytes than in adult myocytes when the diastolic interval was varied over a range of 0.1-1.5 seconds (p less than 0.05). Definition of the time courses of block development at -20 mV indicated that phenytoin had a slightly higher affinity for inactivated sodium channels in neonatal cells. In addition, the time constant of recovery from use-dependent block by phenytoin was found to be significantly longer in neonatal cells than in adult cells at membrane potentials between -160 and -100 mV (p less than 0.001). The marked differences in phenytoin effect on cardiac sodium channels in neonatal versus adult rat cardiac myocytes suggest that there may be significant developmental changes in the sodium channel blocking effects of class I antiarrhythmic drugs in cardiac tissue.
Structural Analysis of Pseudomonas syringae AvrPtoB Bound to Host BAK1 Reveals Two Similar Kinase-Interacting Domains in a Type III Effector
Authors: Wei Cheng, Kathy R. Munkvold, Haishan Gao, Johannes Mathieu, Simon Schwizer, Sha Wang, Yong-bin Yan, Jinjing Wang, Gregory B. Martin, Jijie Chai
Journal: Cell Host & Microbe (2011)
A conversation with Tadataka Yamada
Authors: Ushma S. Neill
Journal: Journal of Clinical Investigation (2012)

Dr. Tadataka “Tachi” Yamada (Figure ​(Figure1)1) joins us for our next Conversation with Giants in Medicine. Born in Japan and trained in the United States as a gastroenterologist, he quickly rose to be the chairman of the Department of Internal Medicine at University of Michigan. He moved to industry and eventually became the Chairman of Research and Development for GlaxoSmithKline. In the next step in his interesting career, he took on the presidency of the Bill and Melinda Gates Foundation Global Health Program. In this capacity, he oversaw over $9,000,000,000 in programs directed at addressing health challenges of the developing world. In 2011, Dr. Yamada moved on to become the Chief Medical and Scientific Officer (CMSO) and Executive Vice President of Takeda Pharmaceuticals. The full interview can be seen on the JCI website, http://www.jci.org/kiosk/cgm.
Safety and efficacy of a fully closed-loop control ventilation (IntelliVent-ASV®) in sedated ICU patients with acute respiratory failure: a prospective randomized crossover study
Authors: Jean-Michel Arnal, Marc Wysocki, Dominik Novotni, Didier Demory, Ricardo Lopez, Stéphane Donati, Isabelle Granier, Gaëlle Corno, Jacques Durand-Gasselin
Journal: Intensive Care Medicine (2012)
Dame Janet's disappointments: Shipman case is a stick to beat the medical profession with
Authors: Gerald Freshwater
Journal: BMJ (2006)

EDITOR—The Shipman case is hardly relevant to the regulation of the medical profession since it is the job of the police to detect murder.1 It has been chosen, however, as a convenient stick with which to beat us. After all, the DVLA was not restructured when the “Yorkshire Ripper” was found to be a lorry driver, although his occupation allowed him to travel around the country murdering women.

The tone of Dame …
Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
Authors: Mark Levis, Farhad Ravandi, Eunice S. Wang, Maria R. Baer, Alexander Perl, Steven Coutre, Harry Erba, Robert K. Stuart, Michele Baccarani, Larry D. Cripe, Martin S. Tallman, Giovanna Meloni, Lucy A. Godley, Amelia A. Langston, Sergio Amadori, Ian D. Lewis, Arnon Nagler, Richard Stone, Karen Yee, Anjali Advani, Dan Douer, W. Wiktor-Jedrzejczak, Gunnar Juliusson, Mark R. Litzow, Stephen Petersdorf, Miguel Sanz, Hagop M. Kantarjian, Takashi Sato, Lothar Tremmel, Debra M. Bensen-Kennedy, Donald Small, B. Douglas Smith
Journal: Blood (2011)
Parathyroid Hormone-Related Protein in Adult T-Cell Leukemia-Lymphoma
Authors: Toru Motokura
Journal: Annals of Internal Medicine (1989)

Objective: To determine whether parathyroid hormone-related protein is synthesized and secreted by the tumor cells of patients with adult T-cell leukemia-lymphoma. Design and Patients: Convenience sample of three patients with adult T-cell leukemia-lymphoma. Two patients developed hypercalcemia, and one patient was normocalcemic. Setting: Inpatient facilities at two university-affiliated medical centers. Intervention: All patients had a lymph node biopsy. In addition, samples of ascitic or pleural fluid, or both, were obtained from these patients. Measurements and Results: Using RNA blot analysis, we showed that parathyroid hormone-related protein (PTHrP) messenger RNAs (mRNAs) were constitutively expressed in the tumor cells from all patients. Cyclic adenosine monophosphate (cAMP) production-stimulating activity, assessed using osteoblast-like UMR106 cells, was demonstrated in the pleural and ascitic fluids from the two patients who developed hypercalcemia. The elution profiles of the cAMP production-stimulating activity in the ascitic fluid extracts were very similar to those of the tumor extracts from hypercalcemic nude rats that had been implanted with a human cancer tumor. Conclusions: Parathyroid hormone-related protein is produced by tumor cells in adult T-cell leukemia-lymphoma, which may be an important factor in the development of hypercalcemia in the patients with this disease. However, the development of hypercalcemia may depend on other factors such as the number of tumor cells, access of the protein into systemic circulation, and the presence of some additional substances.
Drug-Resistant HIV-1
Authors: Douglas L. Mayers
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DETERMINANTS OF RAPID PROGRESSION OF AORTIC VALVE STENOSIS IN HEMODIALYSIS PATIENTS
Authors: Mizuho Hoshina, Hiroshi Wada, Kennichi Sakakura, Nahoko Ikeda, Yoshitaka Sugawara, Norifumi Kubo, Junya Ako, Shin-ichi Momomura
Journal: Journal of the American College of Cardiology (2010)
Direct recording of EDP-EDV relationship in isolated rat left ventricle: effect of diastolic crossbridge formation
Authors: P Schiereck, R Hoefnagel, E L De Beer, B G V Van Heijst, W L Mosterd
Journal: Cardiovascular Research (1994)

The aim was to investigate whether the end diastolic pressure-end diastolic volume (EDP-EDV) relationship of the left ventricle can be influenced by calcium dependent elements, especially at low values of end diastolic pressure.Isolated rat hearts were perfused in a modified Langendorff perfusion system. The EDP-EDV relationship of the left ventricle was investigated. Pressure was recorded with a microtip pressure catheter and volume with a microconductance catheter. Crossbridge cycling was affected by adding calcium antagonists (verapamil, diltiazem, nifedipine at 2.10(-7) M) or by adding the Mg-ATPase blocker BDM (2,3-butanedione-2-monoxime, 10(-3) M) to the perfusate.The above had a negative inotropic effect in systole. At EDP = 0 after stimulation the active isovolumetric pressure was zero. In diastole, BDM shifted the EDP-EDV relationship to slightly smaller EDVs. A decrease of about 5% in the EDV was found at lower EDP values. Ca2+ antagonists increased the EDV up to 40-80% at low EDP values. At higher EDP values only a small increase of EDV (about 10%) was found after verapamil perfusion. The results obtained are interpreted in terms of a three step crossbridge model.At low EDP, diastolic volume is dependent upon weakly bound crossbridges as a function of the [Ca2+] in the cardiac cell.
Boston Hits the Nail on the Thumb
Authors: J. E. Block
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The thumbnail, as a clue to handedness, is an inexpensive, easy, hazardless clinical tool.<sup>1</sup>A sometime forgotten concept in medical practice was emphasized by Dr Pauker (236:819, 1976) in his commentary to a letter published in a recent issue ofThe Journalby Pittsley and Shearn (236:819, 1976). In this day of modern medicine, money, energy, and jeopardy to the patient are often neglected in studies that lead to a diagnosis or determine a prognosis. The casual observation of the thumbnails of a patient with a neurological deficit or one who claims disability after an upper extremity injury costs nothing, is effortless, and has no risk. Therefore, this technique to ascertain dominance should not be discounted in that it lacks 100% accuracy. Other than death, what in medicine is 100%?
Intravascular Coagulation and Hepatic Injury
Authors: DAVID KOHN
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 January 1978Intravascular Coagulation and Hepatic InjuryDAVID KOHN, M.D., ZEV ESTROV, M.D.DAVID KOHN, M.D.Search for more papers by this author, ZEV ESTROV, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-1-130_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The role of disseminated intravascular coagulation in hepatic injury is controversial (1).In the case of Sbarbaro and Bennett (Ann Intern Med86:183-185, 1977) we miss further coagulation studies, especially factor VIII, which is normal or elevated in liver disease and decreased in disseminated intravascular coagulation. This is in contrast to factor VII, which is normal in disseminated intravascular coagulation and decreased in liver disease (2)....References1. HILLENBRAND P, PARBHOO S, JEDRICHOWSKI A, and SHERLOCK S: Significance of intravascular coagulation and fibrinolysis in acute hepatic failure. Gut 15:83-88, 1974 CrossrefMedlineGoogle Scholar2. SHERLOCK S: Disease of the Liver and Biliary System, 5th ed. London, Blackwell Scientific Publications, Inc. 1975, p. 58 Google Scholar1. COLEMAN R, RABBOZ S, and MINNA J: Disseminated intravascular coagulation (DIC): an approach. Am J Med 52:679-789, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID KOHN, M.D.; ZEV ESTROV, M.D.Affiliations: Department of Internal Medicine 'B' Kaplan Hospital Rehovot Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1978Volume 88, Issue 1Page: 130-131KeywordsDisseminated intravascular coagulationLiver diseases ePublished: 1 December 2008 Issue Published: 1 January 1978 PDF downloadLoading ...
Asthma and Rhinitis
Authors: J. Rees
Journal: BMJ (1995)

Ed William W Busse, Stephen T Holgate Blackwell Science, pounds sterling150, pp 1488 ISBN 0 86542246 X

Bacon classified books as those to be tasted or swallowed and a few to be chewed and digested. Asthma and Rhinitis makes a substantial meal. Its 1400 pages from 170 contributors should be tasted, and particular delicacies should be selected for chewing and digesting. The book is a substantial effort and has brought together an impressive range of authors, most of whom write clearly and authoritatively about their subject.

On controversial topics the editors …
Bronchoconstriction induced by ipratropium bromide in asthma: relation to hypotonicity.
Authors: J S Mann, P H Howarth, S T Holgate
Journal: BMJ (1984)

the injection of luteinising hormone releasing hormone is of considerable interest.At three months this rise was absent in samples taken one hour after injection but it was seen in all patients at six months and was more appreciable at 12 months.The mechanism for the rise is unclear but it may arise from either a change in the receptors that makes them unable to accept the analogue or an acceleration in regulation by the receptors.Further studies are needed to explain the mechanism.Rises in testosterone concentration were seen in only three patients, all of whom developed disease progression.The reason why testosterone concentration failed to rise in all patients may relate to prolonged suppression of testicular activity by the analogue.Daily administration of luteinising hormone releasing hormone analogues is not recommended as a long term treatment for carcinoma of the prostate because of its failure to suppress luteinising hormone and testosterone concentrations.The mechanism for this failure has considerable implications in the long term use of peptide analogues.
A novel latent membrane 2 transcript expressed in Epstein-Barr virus–positive NK- and T-cell lymphoproliferative disease encodes a target for cellular immunotherapy
Authors: Christopher P. Fox, Tracey A. Haigh, Graham S. Taylor, Heather M. Long, Steven P. Lee, Claire Shannon-Lowe, Simon O'Connor, Catherine M. Bollard, Javeed Iqbal, Wing C. Chan, Alan B. Rickinson, Andrew I. Bell, Martin Rowe
Journal: Blood (2010)