Resisting Resistance: Maximizing the Durability of Antiretroviral Therapy
Authors: Jon H. Condra
Journal: Annals of Internal Medicine (1998)

Editorials1 June 1998Resisting Resistance: Maximizing the Durability of Antiretroviral TherapyJon H. Condra, PhDJon H. Condra, PhDMerck Research Laboratories; West Point, PA 19486Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-11-199806010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the past 3 years, a veritable explosion of data has yielded new insight into the biology of HIV infection and the pathogenesis of AIDS. It is now well known that HIV infection, even during its long asymptomatic phase, is characterized by high rates of viral replication and destruction of CD4+ cells, which ultimately lead to immune deficiency, AIDS-defining illnesses, and death. Consequently, inhibition of viral replication has assumed primary importance in the control of AIDS.Simultaneously, a new class of potent antiviral drugs, HIV protease inhibitors, was introduced. 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Program and Abstracts of the 5th Conference on Retroviruses and Opportunistic Infections, 1-5 February 1998, Chicago. Alexandria, VA: Foundation for Retrovirology and Human Health; 1998:153. Google Scholar Author, Article, and Disclosure InformationAuthors: Jon H. Condra, PhDAffiliations: Merck Research Laboratories; West Point, PA 19486Corresponding Author: Jon H. Condra, PhD, Department of Antiviral Research, Merck & Co., Inc., WP26-339, West Point, PA 19486. 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Goldie, MD, MPH, Milton C. Weinstein, PhD, Karen M. Kuntz, ScD, and Kenneth A. Freedberg, MD, MScAnal Intraepithelial Neoplasia (AIN) 1 June 1998Volume 128, Issue 11Page: 951-954KeywordsAIDSAmino acidsClinical trialsDrugsGeneticsHIVMutationProtease inhibitorsReverse transcriptase inhibitorsViral replication ePublished: 15 August 2000 Issue Published: 1 June 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...