Cocaine Complications and Pseudocholinesterase
Authors: Devenyi Paul
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 January 1989Cocaine Complications and PseudocholinesteraseDevenyi Paul, MDDevenyi Paul, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-2-167 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor:A growing literature is concerned with the severe complications associated with the abuse of cocaine. For example, papers on acute rhabdomyolysis (1) and on muscle and skin infarction (2) were recently published in your journal. Similar papers, too numerous to quote, have appeared in many other major journals. In addition to muscle necrosis, other reported vascular complications include thrombotic and nonthrombotic myocardial infarction, severe cardiac arrhythmias, strokes, abruptio placentae, intestinal ischemia, and occlusion of the central retinal artery (3, 4). The common denominator in these cases seems to be intense vasoconstriction caused by cocaine's inhibitory effects on...References1. KrohnSlowman-KovacsLeapman KSS. Cocaine and rhabdomyolysis [Letter]. Ann Intern Med. 1988;108:639-40. LinkGoogle Scholar2. Zamora-QuezadaDinermanStadeckerKelly JHMJ. Muscle and skin infarction after free-basing cocaine (crack). Ann Intern Med. 1988;108:564-6. LinkGoogle Scholar3. CreglerMark LH. Medical complications of cocaine abuse. N Engl J Med. 1986;315:1495-9. CrossrefMedlineGoogle Scholar4. DevenyiSchneidermanDevenyiLawby PJRL. Cocaine-induced central retinal artery occlusion. Can Med Assoc J 1988;138:129-30. Google Scholar5. TrundleMarcial DG. Detection of cholinesterase inhibition: the significance of cholinesterase measurements. Ann Clin Lab Sci. 1988;18:345-52. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Addiction Research Foundation University of Toronto Toronto, Ontario M5S 2S1 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byButyrylcholinesterase levels and subjective effects of smoked cocaine in healthy cocaine usersAccelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicityCocaïnePharmacogenetics, Drug-Metabolizing Enzymes, and Clinical PracticeRecurrent metabolic alkalosis and elevated troponins after crack cocaine use in a hemodialysis patientCocaineEcgonine Methyl Ester Protects Against Cocaine Lethality in MiceSensitive Population GroupsButyrylcholinesterase: an enzyme antidote for cocaine intoxicationVariation in Human Plasma Cholinesterase Activity During Low-Dose Cocaine AdministrationThe Effects of Nutrition on Plasma Cholinesterase Activity and Cocaine Toxicity in MiceEnhancing cocaine metabolism with butyrylcholinesterase as a treatment strategyCocaine Detoxification by Human Plasma ButyrylcholinesteraseTherapeutic Use of Butyrylcholinesterase for Cocaine IntoxicationIn Vitro Competitive Inhibition of Plasma Cholinesterase by Cocaine: Normal and Variant GenotypesFacial features of infants exposed prenatally to cocaineDichotomous cardiac and systemic vascular responses to cocaine in conscious ratsAssociation between life-threatening cocaine toxicity and plasma cholinesterase activityCocaine: The Newest Risk Factor for Cardiovascular DiseaseRestraint alters temperature responses to cocaine in spontaneously hypertensive ratsMetabolism of cocaine by human placentas: Implications for fetal exposureGenetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholineDrugs of abuse 15 January 1989Volume 110, Issue 2Page: 167-168KeywordsArteriesCardiac musclesCocaineInfarctionIschemiaMusclesMyocardial infarctionNecrosisRhabdomyolysisVasoconstriction ePublished: 1 December 2008 Issue Published: 15 January 1989 PDF downloadLoading ...