tbuckley/cabot-search huggingface dataset:
Abstract A21: Orphan nuclear receptor TLX recruits lysine-specific demethylase 1 to repress androgen receptor gene transcription and functions to promote hormone-resistant growth of prostate cancer cells
Authors: Lin Jia, Dinglan Wu, Shan Yu, Franky Leung Chan
Journal: Cancer Research (2013)

Abstract Prostate cancer (PCa) is the most frequently diagnosed type of cancer and the second leading cause of death from cancer in males in the United States. The initial growth of most localized PCa is slow and androgen-dependent. Thus, surgical treatment (prostatectomy) and hormone therapy (androgen deprivation) are effective initially. However, many patients relapse and progress to a fatal androgen-independent and bone-metastatic stage shortly when both primary and secondary hormone therapies fail. Unfortunately, the current options for the metastatic hormone-refractory PCa are still limited and mostly ineffective, resulting in high mortality of this disease. Although dysregulated androgen receptor (AR) signaling pathway has been proposed to contribute to the development of hormone-resistance, the involved mechanisms are still not fully defined. Our present findings revealed that the orphan nuclear receptor TLX (NR2E1) exhibited increased expression patterns in androgen-independent and antiandrogen-resistant PCa cells, and also the high-grade and hormone-refractory clinical PCa tissues. Stable overexpression of TLX in AR-positive LNCaP cells could promote both androgen-independent and antiandrogen-resistant cell growth in vitro, and enhance tumor growth capacity in castrated male SCID mice in vivo. Decreased expression of AR and AR target genes in LNCaP-TLX cells were identified, while results of AR-promoter driven luciferase reporter assay also revealed that TLX overexpression could suppress the AR transcription in non-prostatic HEK293 cells. Furthermore, we also identified the direct binding site of TLX on the AR promoter by chromatin immunoprecipitation analyses in TLX-transfected HEK293 cells. The molecular mechanism may involve the TLX-mediated recruitment of lysine-specific demethylase 1 (LSD1) as treatment with an inhibitor of LSD1 pargyline could reverse the transrepressive regulation of TLX on AR-promoter driven luciferase activity and restore AR gene expression levels in LNCaP cells. In summary, our results showed for the first time that overexpression of TLX might contribute to the hormone-resistant PCa cell growth and advanced progression of PCa. LSD1 might serve as a corepressor in TLX-mediated direct transrepression on AR gene expression. This work is partly supported by an RGC-General Research Fund CUHK461012. Citation Format: Lin Jia, Dinglan Wu, Shan Yu, Franky Leung Chan. Orphan nuclear receptor TLX recruits lysine-specific demethylase 1 to repress androgen receptor gene transcription and functions to promote hormone-resistant growth of prostate cancer cells. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr A21.
TRICUSPID ANNULOPLASTY CONCOMITANT WITH LEFT–SIDED CARDIAC SURGERY INDUCES RIGHT VENTRICULAR REMODELING
Authors: Philippe Bertrand, Gille Koppers, Frederik H. Verbrugge, Wilfried Mullens, Rozette Reyskens, Herbert Gutermann, Christiaan J. van Kerrebroeck, Robert A. Dion, Pieter Vandervoort, David Verhaert
Journal: Journal of the American College of Cardiology (2013)
Impact of antifungal treatment on Candida–Pseudomonas interaction: a preliminary retrospective case–control study
Authors: Saad Nseir, Elsa Jozefowicz, Béatrice Cavestri, Boualem Sendid, Christophe Di Pompeo, Florent Dewavrin, Raphaël Favory, Micheline Roussel-Delvallez, Alain Durocher
Journal: Intensive Care Medicine (2006)
Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding
Authors: Valentina Cetica, Yvonne Hackmann, Samantha Grieve, Elena Sieni, Benedetta Ciambotti, Maria Luisa Coniglio, Daniela Pende, Kimberly Gilmour, Paolo Romagnoli, Gillian M. Griffiths, Maurizio Aricò
Journal: Journal of Allergy and Clinical Immunology (2014)

Familial hemophagocytic lymphohistiocytosis (FHL) is a rare and often fatal disorder characterized by defective cellular cytotoxicity and hyperinflammation, and the only cure known to date is hematopoietic stem cell transplantation. Mutations in RAB27A, LYST, and AP3B1 give rise to FHL associated with oculocutaneous albinism, and patients with FHL are usually only screened for mutations in these genes when albinism is observed. A number of patients with FHL and normal pigmentation remain without a genetic diagnosis.We asked whether patients with FHL with immunodeficiency but with normal pigmentation might sometimes have mutations that affected cellular cytotoxicity without affecting pigmentation.We carried out mutation analysis of RAB27A, LYST, and AP3B1 in patients with FHL with pigment dilution, as well as a cohort with no clinical evidence of pigment dilution but no mutations in the other known FHL-related genes (PRF1, STXBP2, and UNC13D).We identify patients with Griscelli syndrome type 2 with biallelic mutations in RAB27A in the absence of albinism. All 6 patients carried mutations at amino acids R141, Y159, or S163 of Rab27a that disrupt the interaction of Rab27a with Munc13-4, without impairing the interaction between melanophilin and Rab27a.These studies highlight the need for RAB27A sequencing in patients with FHL with normal pigmentation and identify a critical binding site for Munc13-4 on Rab27a, revealing the molecular basis of this interaction.
Change in diurnal temperature rhythm in manic-depressive illness.
Authors: G Nikitopoulou, J L Crammer
Journal: BMJ (1976)

The temperatures of six manic-depressive patients were taken every three hours consecutively for many weeks, covering at least one depressive and one manic episode in each patient. While the daily temperature curve was essentially normal in manic phases, with pronounced 24-hour rhythm, during depression the daytime temperatures appeared disorganised, often falling during the morning instead of rising, and with suggestions of a 12-hour rhythm. It may be useful to look on manic-depressive illness as resulting from a desynchronisation of circadian rhythms and to compare the pharmacologies of temperature regulation and mood regulation in psychosis.
THE "DOCTOR'S HEART"
Authors: ALBERT S. HYMAN
Journal: JAMA (1927)

The extensive propaganda for periodic health examinations and the alarming increase in the number of sudden deaths from heart disease in persons apparently enjoying good health have brought unconsciously, perhaps, into the busy life of the average physician a feeling akin to apprehension when the problems of middle age are considered. Whether there is an actual increase in heart disease or whether the increase is only apparent has been the point of discussion in a recent editorial inThe Journal;<sup>1</sup>without doubt, however, the physician is becoming more aware and increasingly cognizant of the number of cardiovascular deaths. While the question may be of general interest, it becomes more sharply focused when the number of physicians meeting cardiovascular deaths is considered. One has only to scan the death columns in the current medical journals both in this country and abroad to realize the significance and truth of this observation,
FURTHER STUDIES ON SHORT COURSES OF ELECTRIC SHOCK TREATMENTS
Authors: NATHAN SAVITSKY, WILLIAM KARLINER
Journal: American Journal of Psychiatry (1947)

Thirty-four additional patients with diagnoses of manic-depressive psychosis, involutional melancholia, and schizophrenia were treated with 5 or fewer electric shock treatments. All the patients had complete remissions for periods up to 28 months. Some patients previously reported, who had been given 5 or fewer treatments, were followed up and were found to have remained well up to 3¾ years after the last treatment.
Late Traumatic Dislocation of the Radial Head
Authors: Otto E. Aufranc
Journal: JAMA (1969)

Dr. Arthur L. Boland: An 8-year-old boy was seen during consultation for a deformity of the right elbow. Three years earlier, the patient had been treated for a fracture of the midshaft of the right ulna. The forearm, reportedly, was held in a long arm plaster cast for three weeks. Soon after removal of the cast, the parents noted a prominence about the right elbow. It was their impression now that the deformity was becoming worse. The child appeared slender, pleasant, and alert. Normal findings were encountered in the general physical examination. The patient had 25° of cubitus valgus in the right elbow, compared with 10° in the left. Supination of the forearm was limited to 45° on the right. The remaining motions of the upper extremity joints were within normal range. The right radial head appeared to be dislocated anteriorly. There was no impairment of neurological or circulatory function.
Does This Patient Have Splenomegaly?
Authors: Steven A. Grover
Journal: JAMA (1993)

<h3>THREE PATIENTS</h3> Among the patients you are seeing today are the following three: The first is an elderly woman who complains of easy fatigability, and her conjunctivae and nail beds are pale. You suspect that she is anemic due to gastrointestinal blood loss, but among your differential diagnoses you consider a lymphoproliferative disorder and decide to examine her for splenomegaly. The second is a college student with failing appetite, ability to concentrate, energy, and grades. You think that he is depressed but want to rule out infectious mononucleosis and decide to examine him for splenomegaly. The third is an otherwise healthy, well-controlled, hypertensive male with a normal cardiovascular examination. As he lies on the examining table, stripped to his waist, you wonder whether you should take the time to examine him for splenomegaly. <h3>WHY EXAMINE THE SPLEEN?</h3> We examine the spleen to see whether it is palpable. Most palpable spleens
Testing Times: We Are Still Some Way From Getting the Best Out of Sensitive Troponin Assays—Reply
Authors: Tobias Reichlin, Christian Mueller
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Iliopsoas Abscess in an Immunocompromised Patient
Authors: DAVID C. LARSON, DAN L. NGUYEN, RONALD G. RAFTERY, JOE C. LEONARD
Journal: Clinical Nuclear Medicine (1988)

Iliopsoas abscesses have a nonspecific clinical presentation and are most commonly secondary to perforation or rupture of abdominal viscera following surgery or trauma. Primary abscesses are rare and are usually Staphylococcal in nature. An iliopsoas abscess, initially detected during bone imaging is presented to demonstrate the complementary roles of nuclear medicine, ultrasound, and CT.
A Collaborative Analysis of Stereotactic Lung Radiotherapy Outcomes for Early-Stage Non–Small-Cell Lung Cancer Using Daily Online Cone-Beam Computed Tomography Image-Guided Radiotherapy
Authors: Inga Siiner Grills, Andrew J. Hope, Matthias Guckenberger, Larry L. Kestin, Maria Werner-Wasik, Di Yan, Jan-Jakob Sonke, Jean-Pierre Bissonnette, Juergen Wilbert, Ying Xiao, Jose Belderbos
Journal: Journal of Thoracic Oncology (2012)
POST-TRAUMATIC PSYCHONEUROSIS—A STATISTICAL SURVEY
Authors: GEORGE N. THOMPSON
Journal: American Journal of Psychiatry (1965)

1. Five hundred cases that were diagnosed "post-traumatic psychoneurosis" were studied statistically with regard to the following variables: a. Variables of historical data, b. Variables of objective signs, c. Variables of symptom complexes, d. Variables of course of the disorder, and e. Variables of results of therapy. 2. Controls consisted of non-traumatically induced psychoneuroses and neurologically injured patients who did not develop psychoneuroses. 3. Definitions are given to clarify a subject that has been confusing to both the medical and the legal professions. 4. Differential diagnostic problems are presented, with a classification of psychogenic factors in other syndromes sometimes found post-traumatically. 5. A series of legal questions compiled from legal examinations and cross-examinations of psychiatrists at hearings and in courts are presented for study. 6. Post-traumatic psychoneurosis is probably the most misunderstood condition that occurs in medico-legal cases, and to make it understood to judges, referees, commissioners and juries, as well as to attorneys and doctors, it must be made tangible, clearly-cut, definite and therefore diagnostically valid. These diagnostic criteria eliminate the arguments of objective versus subjective, for everything in medicine is both objective and subjective.
Expression of Kunitz Protease Inhibitor–Containing Forms of Amyloid β-Protein Precursor Within Vascular Thrombi
Authors: Irene M. Lang, Kenneth M. Moser, Raymond R. Schleef
Journal: Circulation (1996)

Background The presence of patent neovessels within vascular occlusions in chronic thromboembolic pulmonary hypertension suggests that local mechanisms exist to regulate the coagulation system. This study investigated the expression of a potent inhibitor of Factor IXa and Factor XIa (ie, protease nexin-2/amyloid β-protein precursor, AβPP) in the organized vascular occlusions harvested from patients with this disease. Methods and Results Immunohistochemical analysis revealed intense immunoreactivity for AβPP in the single layer of cells that line the neovessels. A positive signal was also detected by in situ hybridization analysis with the use of a 35 S-UTP–labeled antisense riboprobe that recognizes the various alternatively spliced mRNA forms of this molecule. To identify the forms of AβPP produced within the thrombi, total RNA was extracted from the thrombi, reverse transcribed, and subjected to amplification with the use of the polymerase chain reaction (PCR) and primers that flank the region encoding the alternatively spliced 56–amino acid Kunitz-type protease inhibitor (KPI) domain. The major PCR products consisted of 255 bp and 312 bp and corresponded to transcripts encoding this domain (ie, AβPP 751 and AβPP 770 ). In situ hybridization analysis with the use of a 35 S-UTP–labeled antisense riboprobe complementary to the region encoding the KPI domain confirmed the presence of these mRNA species in nucleated cells lining the neovessels. Conclusions The expression of KPI-containing isoforms of AβPP in thrombus endothelial cells may represent one mechanism utilized in this disease to shift the local hemostatic balance and preserve regional vessel patency.
Expression of human hair keratin basic 1 in pilomatrixoma. A study of 128 cases
Authors: None CRIBIER, None ASCH, None REGNIER, None RIO, None GROSSHANS
Journal: British Journal of Dermatology (1999)

Hard keratins are expressed in normal hair and nails, and are characterized by a higher cysteine content than cytokeratins. Previous studies have suggested a coexpression of hard keratins and cytokeratins in pilomatrixoma, a benign follicular tumour which could originate from the hair matrix. Human hair keratin basic 1 (hHb1) is a newly characterized hair keratin which is expressed specifically by cortical cells of the normal hair shaft. A preliminary study has suggested that hHb1 could be expressed in pilomatrixoma. In order to confirm this hypothesis, we have studied a series of 128 pilomatrixomas by in situ hybridization, using a 35S‐labelled hHb1‐specific probe. The anti‐sense probe was used as a negative control. Among these pilomatrixomas, six were early cases, 60 were classified into the intermediate stage (either fully developed or early regressive cases) and 62 were late regressive tumours made of shadow cells only. Forty‐seven tumours showed hHb1 expression (37%), all being intermediate stage pilomatrixomas. The areas positively stained by the probe were band‐like structures made of transitional cells only, which were very close to cells showing tricholemmal keratinization features. Neither the basophilic matrix cells nor the shadow cells expressed hHb1. Our results suggest that pilomatrixomas can differentiate towards cortical cells during their maturation process, as this keratin is specifically expressed in the cortex of the normal hair shaft. These data are consistent with previous studies which showed the expression of a hard keratin group in transitional cells by immunohistochemistry. The histogenesis of basophilic cells of pilomatrixoma is controversial, but it is likely that transitional cells represent an equivalent of the hair cortex.
Elections to Scottish NHS boards attract few voters and high costs
Authors: B. Christie
Journal: BMJ (2011)

Fewer than one person in five turned out to vote in the first ever direct elections to NHS boards in Scotland, which have cost over £11 (€13; $18) per voter.

The combination of low turnout and high costs has been criticised by doctors’ leaders who say the £772 986 spent on the election would have been much better invested in direct patient care.

Legislation was passed in Scotland in 2009 to pilot direct elections to NHS boards to see if this would improve public participation and accountability in decision making. Voting took …
US Congress holds hearings on outbreak of influenza A (H1N1)
Authors: B. Roehr
Journal: BMJ (2009)

Questions on the threat posed by the outbreak of influenza A (H1N1) remained unanswered after three days of congressional hearings in Washington, DC. But the meetings dampened down media frenzy through the constant repetition of the limited facts that were known.

“We are better situated to face the outbreak now than we would have been 10 years ago,” said the representative Henry Waxman, at a 30 April hearing of the energy and commerce committee. That was because of resources and planning devoted to the threat of pandemic flu.

In calling for additional funding he said, “I hope …
Modeling of cancer metastasis and drug resistance via biomimetic nano-cilia and microfluidics
Authors: Ching-Te Kuo, Chi-Ling Chiang, Chi-Hao Chang, Hao-Kai Liu, Guan-Syuan Huang, Ruby Yun-Ju Huang, Hsinyu Lee, Chiun-Sheng Huang, Andrew M. Wo
Journal: Biomaterials (2013)
Abstract 2541: Inhibition of DNA repair by trifluoperazine sensitizes human lung cancer cells to apoptosis associated with lysosomal dysfunction following prolonged G2-M checkpoint arrest
Authors: Dali Zong, Petra Hååg, Rolf Lewensohn, Kristina Viktorsson
Journal: Cancer Research (2011)

Abstract Clinical therapy resistance severely limits the efficacy of DNA damaging chemotherapy in human lung non-small cell lung carcinoma (NSCLC). Here we show that chemosensitization can be achieved in NSCLC by combining clinically-relevant DNA damaging agents with trifluoperazine (TFP). Colony formation assays demonstrated that TFP significantly potentiated the cytotoxicity of bleomycin and cisplatin in NSCLC cell lines. TFP impaired the repair of bleomycin- and cisplatin-induced DNA double strand breaks (DSBs), and consequently delayed the recovery from DNA damage-induced G2-M checkpoint (12 h vs at least 24 h). At later time points (&amp;gt; 24 h), NSCLC cells co-treated with TFP and bleomycin or cisplatin were able to overcome the initial G2-M checkpoint arrest, as evidenced by the reappearance of the mitosis markers and reduction in CFSE fluorescence. However, these cells showed increased micronucleation, apoptosis and gradual loss of proliferative capacity due to secondary G2-M arrest. Notably, TFP co-treated NSCLC cells underwent limited lysosomal membrane permeabilization (LMP) prior to Bak/Bax activation and mitochondrial depolarization. In turn this led to robust activation of caspase-3 preferentially in cells residing in the G2-M phase. In conclusion, our data supports the notion that by antagonizing DSB repair, TFP forces NSCLC cells into prolonged checkpoint arrest (whether initial or secondary) which sensitizes them to apoptosis associated with lysosomal dysfunction. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2541. doi:10.1158/1538-7445.AM2011-2541
Increased risk of cognitive impairment in cirrhotic patients with bacterial infections
Authors: Manuela Merli, Cristina Lucidi, Ilaria Pentassuglio, Valerio Giannelli, Michela Giusto, Vincenza Di Gregorio, Chiara Pasquale, Silvia Nardelli, Barbara Lattanzi, Mario Venditti, Oliviero Riggio
Journal: Journal of Hepatology (2013)
Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation
Authors: Emmanuel Clave, Marc Busson, Corinne Douay, Régis Peffault de Latour, Jeannig Berrou, Claire Rabian, Maryvonnick Carmagnat, Vanderson Rocha, Dominique Charron, Gérard Socié, Antoine Toubert
Journal: Blood (2009)
Pancreatic Sphincter Precutting to Gain Selective Access to the Common Bile Duct: A Series of 172 Patients
Authors: R. Akashi, T. Kiyozumi, K. Jinnouchi, M. Yoshida, Y. Adachi, K. Sagara
Journal: Endoscopy (2004)

Background and Study Aims: Several precutting techniques have been described in cases of failed access to the common bile duct. We describe our experience with pancreatic sphincter precutting in an upward direction, and report its success rates and complications. Patients and Methods: A total of 172 patients underwent a procedure using this technique between January 1989 and December 2001. The technique consisted of a medium-to-large precut along the midline, above the papillary elevation, using either the common channel or the pancreatic duct in the ampulla of Vater as a guide. The septum between the pancreatic duct and the bile duct was removed and separate openings to the pancreatic and bile ducts were created, followed by complete biliary sphincterotomy.
OCCURRENCE OF DIABETIC GANGRENE IN AN UNUSUAL LOCATION
Authors: C. W. W. Elkin
Journal: JAMA (1934)

This case of diabetes mellitus is reported because of the unusual location of the complicating gangrene and infection. Mrs. S. L., aged 42, a married Jewish woman, seen in October 1931, gave a history of having had diabetes mellitus for six years, without any dietary or insulin treatment. After a short period of supervision of treatment, the patient went through a pelvic operation quite satisfactorily in November 1931, but refused to follow dietary instructions or take insulin. She was not seen again until Nov. 28, 1933, when she was found in a stuporous condition with "air hunger" and "acetone breath." Over the lower part of each labium majus was a large gangrenous area, from one of which (the right) was draining considerable pus. In addition there was a gangrenous area over each ischial region, with considerable sloughing of tissue on the right side. Between the labial and ischial areas involved