tbuckley/cabot-search huggingface dataset:
Atrophic Gastritis after Billroth I Gastrectomy
Authors: G. Kliems, K. Paquet, H. Lindstaedt, S. Miederer
Journal: Endoscopy (1979)

The gastric mucosa of a stomach resected according to Billroth I operation is subject to a process of aging twice as intense as that of a non-resected one. Atrophy after Billroth I gastrectomy increased by 3% on an average per annum. As a result, a typical distribution of degrees of inflammation in the region of the greater curvature became evident. Atrophic gastritis occurres especially near the anastomosis and decreases in the direction of the fornix. The possibility is discussed that resected patients--in contrast to non-resected--are afflicted with stomach cancer primarily on account of the more intense and earlier mucosal atrophy.
Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution
Authors: Ryan F. Donnelly, Martin J. Garland, Desmond I.J. Morrow, Katarzyna Migalska, Thakur Raghu Raj Singh, Rita Majithiya, A. David Woolfson
Journal: Journal of Controlled Release (2010)
Task Force Readying First Wave of New Prevention Guidelines
Authors: Tom Reynolds
Journal: Annals of Internal Medicine (2001)

Current Clinical Issues20 February 2001Task Force Readying First Wave of New Prevention GuidelinesTom ReynoldsTom ReynoldsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-4-200102200-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The third U.S. Preventive Services Task Force is preparing to release its first set of new, updated recommendations. The new recommendations will reflect major changes in both form (how they are written and disseminated) and function (how they are formulated).The first four reports, which deal with screening for lipid disorders, skin cancer, chlamydial infection, and bacterial vaginosis in pregnancy, will be published as a supplement to the American Journal of Preventive Medicine(Am J Prev Med. 2001; 20: 3 [Suppl]) and on the Agency for Healthcare Research and Quality (AHRQ) Web site (www.ahrq.gov). The current plan is for subsequent reports ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByToward a Model of Prostate Cancer Information SeekingDomains-based Outcomes Assessment of Continuing Medical Education 20 February 2001Volume 134, Issue 4Page: 349-352KeywordsCancer preventionCancer screeningEvidence based medicineHealth carePregnancyPreventive medicinePrimary care physiciansRandomized trialsSystematic reviewsType 2 diabetes ePublished: 20 February 2001 Issue Published: 20 February 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Sixth Fishbein Fellow begins journalism studies
Authors: Kimberly Glasbrenner
Journal: JAMA (1984)

Helene M. Cole, MD, is joining the staff of<i>The Journal of the American Medical Association</i>this month as the American Medical Association's sixth Morris Fishbein Fellow in medical journalism. The 31-year-old physician describes the opportunity as a chance to "come home," in more ways than one, to Chicago, where she grew up. Cole completed her first year as a clinical pathology resident this spring at the Indiana University Medical Center in Indianapolis. She is married to a cellular biologist, Michael Yates, who will return to Northwestern University (where he earned his PhD degree) to do postgraduate work, studying protein synthesis. They are looking forward to being reunited with friends and family and—as Cole puts it—"to once again take advantage of Chicago's fine arts opportunities." Cole realizes that as far as her career is concerned, she came full circle while in medical school: "I knew I didn't want to be
Plasma Therapy for Thrombotic Thrombocytopenic Purpura
Authors: Richard H. Aster
Journal: New England Journal of Medicine (1985)

Thrombotic thrombocytopenic purpura is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and fluctuating, often bizarre, neurologic abnormalities. Fever and renal failure are also prominent in some patients. The classic histologic lesions, which appear to cause most of the symptoms, are microthrombi consisting mainly of platelets, which can be found in the capillaries of almost any tissue. Before 1965, thrombotic thrombocytopenic purpura was thought to be almost universally fatal. Subsequently, increasing numbers of patients treated with various combinations of corticosteroids, splenectomy, platelet inhibitors, and other agents were reported to have survived, but no consensus emerged with respect to the most effective regimen. . . .
Case 8-1968
Authors: John A. Mills, Wallace H. Clark, Edward P. Richardson
Journal: New England Journal of Medicine (1968)

Presentation of Case First admission. A twenty-eight-year-old man entered the hospital because of pain in the hip.Twelve years previously he was found to have proteinuria. Six years thereafter he had an episode of fever, arthralgia and a skin rash; L.E.-cell tests were positive, and prednisone was prescribed. Fifteen months before entry ecchymosis and pain in the right hip developed. He was admitted to another hospital, where aspiration of an abscess cavity in the hip yielded Salmonella typhimurium. A faint basal diastolic murmur was heard. Penicillin was administered for six weeks. During the ensuing months the pain in . . .
So-called Stevens--Johnson Syndrome
Authors: B. A. Thomas
Journal: BMJ (1950)

<h3>Abstract</h3> Here we show that deleting NMNAT2 from cortical glutamatergic neurons (NMNAT2 cKO) results in progressive axonal loss, neuroinflammation, small hippocampi and enlarged ventricles. Interestingly, dramatic neuroinflammation responses were observed around the long-range axonal tracts of NMNAT2 cKO cortical neurons. In addition to the neurodegenerative-like phenotype, we also found the absence of whisker-representation patterns “barrels” in the primary somatosensory cortex of NMNAT2 cKO mice. These observations suggest that NMNAT2 is required in developing cortical circuits and in maintaining the health of cortical neurons. Unbiased transcriptomic analysis suggests that NMNAT2 loss in cortical neurons after axonal outgrowth phase upregulates mitochondria function while greatly reducing synaptogenesis pathways. Complete loss of Sarm1 function in NMNAT2 cKO mice restores barrel map formation and axonal integrity and abolishes the inflammatory response. Interestingly, reducing Sarm1 function in NMNAT2 cKO mice by deleting only one copy of Sarm1 restores barrel map formation but did not diminish the neurodegenerative-like phenotype. Only complete loss of Sarm1 prevents neurodegeneration and inflammatory responses.
206 Safe use of peg-ifn and ribavirin in hcv-cirrhotic patients undergoing partial splenic embolization
Authors: R. Bárcena, A. Moreno, J.R. Foruny, C. Quereda, J. Blazquez, L.A. Gil-Grande, J. Moreno, M.J. Perez-Elias, A. Antela, J. Sanchez, M. Rivero, M. Rodriguez-Gandia, S. Moreno
Journal: Journal of Hepatology (2006)
HPV vaccination reduced cytologic abnormalities compared with control vaccination in young women
Authors: Brian Budenholzer
Journal: Annals of Internal Medicine (2013)

Source Citation Rodríguez AC, Solomon D, Herrero R, et al; CVT group. Impact of human papillomavirus vaccination on cervical cytology screening, colposcopy, and treatment. Am J Epidemiol. 2013;178:752-60. 23843026
Left Ventricular Phase Analysis of Equilibrium Radioventriculograms in Patients with Ischemic Heart Disease
Authors: M V Yester, J R Logic, W J Rogers, S E Papapietro, J A Mantle, R Smith, C E Rackley
Journal: Clinical Nuclear Medicine (1981)

Yester, M V; Logic, J R; Rogers, W J; Papapietro, S E; Mantle, J A; Smith, R; Rackley, C E Author Information
What Is the Best Approach to Reducing Birth Defects Associated with Isotretinoin?
Authors: Lorien Abroms, Edward Maibach, Katherine Lyon-Daniel, Steven R Feldman
Journal: PLoS Medicine (2006)

Isotretinoin is an effective treatment for severe acne, a condition which can be physically, emotionally, and socially disabling. Because the drug is teratogenic, causing severe birth defects, women taking the drug are directed to avoid pregnancy. In the United States, a series of risk reduction programs have been implemented that aim to prevent pregnant women from taking the drug and to prevent women taking it from getting pregnant. The most recent, and most stringent, is an Internet-based, performance-linked system called iPLEDGE, which tries to ensure that the drug is dispensed only when there is documentary proof that the patient is not pregnant and is using two forms of birth control. Is iPLEDGE the best way to reduce isotretinoin birth defects, or is it an unproven and overly burdensome system?
S12 Effect Of Baseline Fvc On Decline In Lung Function With Nintedanib: Results From The Inpulsis Trials
Authors: U. Costabel, Y. Inoue, L. Richeldi, H. Collard, S. Stowasser, I. Tschoepe, A. Azuma
Journal: Thorax (2014)

<h3>Background</h3> Nintedanib, an intracellular inhibitor of tyrosine kinases, is in development for the treatment of idiopathic pulmonary fibrosis (IPF). The INPULSIS™ trials were two replicate randomised, double-blind, placebo-controlled, 52-week Phase III trials that assessed the efficacy and safety of nintedanib 150 mg twice daily in patients with IPF. The primary endpoint was the annual rate of decline in forced vital capacity (FVC), which was significantly reduced in the nintedanib group compared with placebo in both trials. <h3>Aim</h3> To assess the impact of baseline FVC on the effect of nintedanib on rate of decline in FVC. <h3>Methods</h3> A pre-specified subgroup analysis of patients with baseline FVC &gt;70% versus ≤70% of predicted value was undertaken using pooled data from both trials. <h3>Results</h3> 700 patients (nintedanib 431, placebo 269) had baseline FVC &gt;70% predicted and 361 patients (nintedanib 207, placebo 154) had baseline FVC ≤70% predicted. For patients with a baseline FVC &gt;70% predicted, mean age was 67.4 years, 76.9% were male, 55.7% were White and mean carbon monoxide diffusion capacity (DL<sub>CO</sub>) was 4.0 mmol/min/kPa. For patients with a baseline FVC ≤70% predicted, mean age was 65.5 years, 83.9% were male, 60.4% were White and mean DL<sub>CO</sub> was 3.6 mmol/min/kPa. There was no significant treatment by subgroup interaction: the difference in adjusted annual rate of decline in FVC between the nintedanib and placebo groups was comparable in both subgroups. <h3>Conclusion</h3> A subgroup analysis of pooled data from the INPULSIS™ trials showed that nintedanib 150 mg twice daily slowed the decline in lung function in patients with IPF, independent of severity of lung function impairment at baseline.
The Antihypertensive Effect of Verapamil at Extremes of Dietary Sodium Intake
Authors: John P. Nicholson, Lawrence M. Resnick, John H. Laragh
Journal: Annals of Internal Medicine (1987)

Restricting sodium intake is a primary recommendation for patients with hypertension, including those receiving drug treatment. Few studies, however, have examined the impact of different levels of sodium intake on the effectiveness of antihypertensive drugs. We administered two courses of verapamil to 13 patients with essential hypertension during a low-sodium (NaCl, 9 meq/d) and high-sodium (212 meq/d) diet. Overall, verapamil was an effective antihypertensive agent, but expressed its greatest potency in the lower-renin, sodium-sensitive subgroup (change in systolic/diastolic blood pressure, -18.8/-17.7 in sodium-sensitive patients compared with -11.4/ -8.7 in sodium-insensitive patients; p < 0.05). Moreover, the antihypertensive efficacy of verapamil was not blunted by the high-sodium intake. Thus, dietary sodium restriction may not be necessary or appropriate in the treatment of essential hypertension with verapamil; salt-induced cellular calcium uptake may be involved in the phenomenon of sodium sensitivity.
Measurement of myocardial blood flow by ultrafast computed tomography.
Authors: C J Wolfkiel, J L Ferguson, E V Chomka, W R Law, I N Labin, M L Tenzer, M Booker, B H Brundage
Journal: Circulation (1987)

Myocardial blood flow was analyzed by radioisotope-labeled microspheres and ultrafast computed tomography (CT) in 16 closed-chest, anesthetized dogs. The first set of 10 dogs had CT and microsphere measurements before and after chromonar-induced increases in myocardial blood flow. A second set of six dogs had flows measured at control and during temporary reductions in regional flow produced by balloon cuff occlusion of the left anterior descending coronary artery. All dogs had four-slice, 20-instance CT scans after injection of a medium bolus (0.35 ml/kg) of contrast medium into a femoral vein simultaneous with injection of microspheres into the left atrium. CT myocardial flow was calculated as the change in myocardial CT numbers divided by the area from a blood pool time-density curve. A wide range of myocardial blood flows was produced as determined by microspheres (0 to 6.7 ml/min/g). Global flow of the first set of dogs was shown to have excellent correlation (r = .95, n = 17) for a limited range (.4 less than X less than 1.4 ml/min/g) of flows. Regional flows of these measurements demonstrated less correlation (r = .63, n = 110) but extended the range of flow to 1.7 ml/min/g. At higher flows (greater than 2.5 ml/min/g) the correlation for global and regional flows was not significantly different than zero. Regional ischemic flow correlation extended the linear range of flow to 0 ml/min/g (r = .62, n = 17). These results show that CT can measure myocardial blood flow over a limited but clinically relevant range of flows defined as slightly above normal to ischemic. These results indicate that another preparation of CT flow measurement must be sought for quantification of myocardial perfusion values significantly above normal.
Long-Term Mortality After Percutaneous Coronary Intervention With Drug-Eluting Stent Implantation Versus Coronary Artery Bypass Surgery for the Treatment of Multivessel Coronary Artery Disease
Authors: Duk-Woo Park, Sung-Cheol Yun, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Myeong-Ki Hong, Jae-Joong Kim, Suk Jung Choo, Hyun Song, Cheol Hyun Chung, Jae-Won Lee, Seong-Wook Park, Seung-Jung Park
Journal: Circulation (2008)

Background— Although previous studies have compared the treatment effects of percutaneous coronary intervention and coronary artery bypass grafting (CABG), the long-term outcomes beyond 1 year among patients with multivessel coronary artery disease who underwent percutaneous coronary intervention with drug-eluting stents (DES) or CABG have not been evaluated. Methods and Results— Between January 2003 and December 2005, 3042 patients with multivessel disease underwent coronary implantation of DES (n=1547) or CABG (n=1495). The primary end point was all-cause mortality. In a crude analysis, the rate of long-term mortality was significantly higher in patients who underwent CABG than in those who underwent DES implantation (3-year unadjusted mortality rate, 7.0% for CABG versus 4.4% for percutaneous coronary intervention; P =0.01). However, after adjustment for baseline differences, the overall risks of death were similar among all patients (hazard ratio, 0.85; 95% confidence interval [CI], 0.56 to 1.30; P =0.45), diabetic patients (hazard ratio, 1.76; 95% CI, 0.82 to 3.78; P =0.15), and patients with compromised ventricular function (hazard ratio, 1.39; 95% CI, 0.41 to 4.65; P =0.60). In the anatomic subgroups, mortality benefit with DES implantation was noted in patients with 2-vessel disease with involvement of the nonproximal left anterior descending artery (hazard ratio, 0.23; 95% CI, 0.01 to 0.78; P =0.016). The rate of revascularization was significantly higher in the DES than in the CABG group (hazard ratio, 2.81; 95% CI, 2.11 to 3.75; P &lt;0.001). Conclusions— For the treatment of multivessel coronary artery disease, percutaneous coronary intervention with DES implantation showed equivalent long-term mortality as CABG.
STUDIES ON THE ENTERO-HEPATIC CIRCULATION OF 14C PORPHYRINS
Authors: G. M. Stathers, K. F. Aronsen, B. Haeger-Aronsen
Journal: British Journal of Dermatology (1969)

Journal Article STUDIES ON THE ENTERO‐HEPATIC CIRCULATION OF 14C PORPHYRINS Get access G. M. Stathers, G. M. Stathers Departments of Medicine and Surgery, University of Lund, General Hospital, Malmö, Sweden Search for other works by this author on: Oxford Academic Google Scholar K. F. Aronsen, K. F. Aronsen Departments of Medicine and Surgery, University of Lund, General Hospital, Malmö, Sweden Search for other works by this author on: Oxford Academic Google Scholar B. Haeger‐Aronsen B. Haeger‐Aronsen Departments of Medicine and Surgery, University of Lund, General Hospital, Malmö, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 4, 1 April 1969, Pages 276–279, https://doi.org/10.1111/j.1365-2133.1969.tb13980.x Published: 01 April 1969 Article history Accepted: 30 September 1968 Published: 01 April 1969
RADIOLABELING OF MONOCLONAL AMTITUMOR ANTIBODIES
Authors: Samuel E. Halpern, Peter L. Stern, Phillip L. Hagan, Agnes Chen, Gary S. David, Walter J. Desmond, Thomas N. Adams, Richard M. Bartholomew, James M. Frincke, Cathy E. Brautigam
Journal: Clinical Nuclear Medicine (1981)

Halpern, Samuel E.; Stern, Peter L.; Hagan, Phillip L.; Chen, Agnes; David, Gary S.; Desmond, Walter J.; Adams, Thomas N.; Bartholomew, Richard M.; Frincke, James M.; Brautigam, Cathy E. Author Information
Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma
Authors: Jessica Dal Col, Paola Zancai, Liliana Terrin, Massimo Guidoboni, Maurilio Ponzoni, Alessandro Pavan, Michele Spina, Stefano Bergamin, Silvana Rizzo, Umberto Tirelli, Anita De Rossi, Claudio Doglioni, Riccardo Dolcetti
Journal: Blood (2008)
Transpapillary Bile Duct Drainage with a Large-caliber Endoprosthesis
Authors: G. Kautz
Journal: Endoscopy (1983)

A new method for transpapillary bile duct drainage by means of a large-caliber endoprosthesis is described. It facilitates the transpapillary introduction of endoprostheses with an internal diameter of 3.5 to 5 mm irrespective of the actual diameter of the duodenoscope instrument channel. The method has been successfully employed in 6 out of 8 patients with malignant obstructive jaundice, uncomplicated by cholangitis. It offers an acceptable alternative to palliative surgical biliodigestive anastomosis.
Magnetic Resonance Imaging of the Brain, Head, and Neck: A Text Atlas
Authors: Michael S. Huckman
Journal: JAMA (1986)

This is an excellent introductory textbook for physicians who interpret magnetic resonance images. It includes physics, biophysics, and anatomy. The three basic sections deal with the physical principles involved in the generation of these images, the effects of magnetic resonance imaging devices on living tissues, and the normal anatomy seen in such images of the brain, head, neck, and cervical area of the spine. The section on the fundamentals of magnetic resonance image interpretation is written with the clinician in mind. In the explanation of the physical basis for the different kinds of relaxation times, an example demonstrates the difference in the appearance of cerebrospinal fluid within the subarachnoid space and when forced into periventricular white matter as interstitial edema. Most of the illustrations in this section are large, refreshingly free of arrows, and of good quality. In almost every instance, the authors show a particular entity using different pulse
Impairment of central motor conduction to the diaphragm in stroke.
Authors: T Similowski, M Catala, G Rancurel, J P Derenne
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Respiratory complications are common in patients with stroke, but the involvement of the diaphragm in this setting is not completely understood. The purpose of this study was to assess corticodiaphragmatic pathways in patients with vascular hemiplegia. Fifteen patients were studied, nine with a capsular type of hemiplegia. Seven age-matched subjects served as the control group, and eight healthy young volunteers were studied to validate the methods by comparison with the literature. Diaphragm electromyogram was recorded bilaterally, using surface electrodes. Abductor pollicis brevis electromyogram was also recorded. After having checked the integrity of peripheral conduction, corticofugal pathways were studied using cortical magnetic stimulation, a reproducible and patient-independent stimulus. Left and right conduction times to the diaphragm were symmetrical in the control subjects, the young volunteers, and the six patients with hemiplegia but without capsular lesion (16.5 to 20.1 ms). Conversely, they were markedly asymmetrical in patients with capsular hemiplegia, diaphragm response on the plegic side being abolished or markedly delayed. Although the clinical impact of these findings remains to be determined, this study confirms that "central diaphragm paralysis" can be present in stroke. It also indicates that there is no bilateral motor representation of each hemidiaphragm.
The use of paraffin-processed tissue and the immunoperoxidase technique in the diagnosis of bullous diseases, lupus erythematosus and vasculitis
Authors: MARLYN L. TURBITT, RONA M. MACKIE, H. YOUNG, IRENE CAMPBELL
Journal: British Journal of Dermatology (1982)

Journal Article The use of paraffin‐processed tissue and the immunoperoxidase technique in the diagnosis of bullous diseases, lupus erythematosus and vasculitis Get access MARLYN L. TURBITT, MARLYN L. TURBITT Department of Dermatology, University of Glasgow Dr Marlyn L.Turbitt, University Department of Dermatology, Anderson College Building, 56 Dumbarton Road, Glasgow G11 6NU. Search for other works by this author on: Oxford Academic Google Scholar RONA M. MACKIE, RONA M. MACKIE Department of Dermatology, University of Glasgow Search for other works by this author on: Oxford Academic Google Scholar H. YOUNG, H. YOUNG Department of Dermatology, University of Glasgow Search for other works by this author on: Oxford Academic Google Scholar IRENE CAMPBELL IRENE CAMPBELL Department of Dermatology, University of Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 106, Issue 4, 1 April 1982, Pages 411–418, https://doi.org/10.1111/j.1365-2133.1982.tb04533.x Published: 01 April 1982 Article history Accepted: 25 June 1981 Published: 01 April 1982
Toxic Encephalopathy Apparently Related to the Use of an Insect Repellent
Authors: Joyce Gryboski, David Weinstein, Nelson K. Ordway
Journal: New England Journal of Medicine (1961)

IN view of the popular use of insect repellents during the summer months, it is the purpose of this report to describe a case of toxic encephalopathy related to the use of the product, "OFF." There are no previously reported cases in human beings.Case ReportA 3 1/2-year-old girl was admitted to the Pediatric Service of the Grace–New Haven Community Hospital at 4 p.m. on July 26, 1959, with the chief complaint of "shaking and crying spells" of 1 day's duration. She had been well until the previous day, when at 9 a.m. she was found on the floor. . . .