tbuckley/cabot-search huggingface dataset:
John Gibson (Ian) Taylor
Authors: Alan Green, Neil Cardoe
Journal: BMJ (2006)

​FormerFormer consultant orthopaedic surgeon Norfolk and Norwich Hospital (b 1918; q St Mary's Hospital, London 1941; VRD, FRCS), died after deteriorating health and muscle wasting disease on 24 August 2005.



Figure 1



Ian Taylor joined the Royal Navy in 1942 and served in the North Atlantic escorting convoys to Russia, being discharged surgeon lieutenant commander in 1946. His last trip abroad was to Murmansk in 2001, when many were awarded a medal of honour for the risks taken by the convoys. Ian became a consultant in 1954. Embracing all aspects of orthopaedics, he excelled in newer techniques. Surgery of rheumatoid disease helped his medical colleagues establish a recognised centre of excellence. He leaves a wife, Fodhla.
The relationship between abnormal echocardiographic septal motion and myocardial perfusion in patients with significant obstruction of the left anterior descending artery.
Authors: A J Kolibash, B M Beaver, P K Fulkerson, S Khullar, R F Leighton
Journal: Circulation (1977)

authors have further suggested that AESM implies not only a critical left anterior descending lesion, but that the lesion is proximal to the first septal perforator branch.10 13 Despite the usefulness of coronary angiography in defin- ing the presence of significant obstruction of the major cor- onary arteries, the procedure does not allow visualization of small vessels and therefore does not provide complete information concerning resting myocardial perfusion.
A Successful Case of Gastrotomy for Intestinal Obstruction
Authors: A. Smith
Journal: BMJ (1883)

annual loss is 830, or that of a strong infantry regiment.About 1870, it became a question if the alterations in the system of recruiting did not throw an inferior class of men into the service, their physical qualities giving a lower standard than obtained under the old system.I find that, in the first decade, of 209,763 civilians ex- amined, the rejected for diseases of the heart, arteries, and veins were 60.6 per 1,000; and in the second decade of 364,187 civilians examined, the rejected for the same grounds were 42.8 per 1,000.This would seem to indicate a stricter examination in the former period; but be this the case or not, we have but 126,297 recruits passed in the one decade, and 248,873, nearly double, in the second; and from this fact alone, the area of selection being limited, the opinion may be held to be well founded that the standard of physical qualification on entrance is likely to fall rather than to rise.A consideration not to be overlooked is that of age.In 1880, of 64,866 men abroad, 47,261 were between 20 and 30; 13,865 between 30 and 40; 2,294 under 20; and 1,446 above 40.In 1875, of 64,618 men at home 41,289 were between 20 and 30; 23,347 between 30 and 40; 3,444 above 40; and 12,771 under 20.These ages are favourable, though the number at home under 20 is higher than de- sirable, the period of training being doubly trying to an immature recruit.
Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis
Authors: Hiroshi Kimura, Hiroki Miyashita, Yasuhiro Suzuki, Miho Kobayashi, Kazuhide Watanabe, Hikaru Sonoda, Hideki Ohta, Takashi Fujiwara, Tooru Shimosegawa, Yasufumi Sato
Journal: Blood (2009)
siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen–specific CD8+ T cells
Authors: Willemijn Hobo, Frans Maas, Niken Adisty, Theo de Witte, Nicolaas Schaap, Robbert van der Voort, Harry Dolstra
Journal: Blood (2010)
Philip Michael Stell
Authors: Alan G Kerr
Journal: BMJ (2004)

Philip Stell had an outstanding career in laryngology and head and neck surgery, and, following early retirement through ill health, became an acclaimed medieval historian.

Appointed senior lecturer and consultant in otolaryngology in Liverpool, he confined his practice to the discipline of laryngology and head and neck surgery, the first to do so in the United Kingdom. He was appointed to a chair in Liverpool in 1979.

Philip Stell dealt with all aspects of head and neck malignancies and developed an exceptional reconstructive expertise. Years ahead of his time he emphasised the importance of knowing the detailed outcomes of surgery and soon developed his own extensive, computerised database, strongly advocating statistical analysis of all surgical results.

He became a dominant figure in head and neck surgery in Europe, which was facilitated by his ability to speak fluently in Dutch, German, French, and Spanish. He was an Associate of the Institute of Linguists. It was his practice to deliver overseas lectures in the local language and his linguistic ability led to the translation of 11 foreign language textbooks into English.​English.




Figure 1




He was a big man in every way, but his height, 6 feet 7 inches (2.03 metres), made air travel uncomfortable and he rarely travelled beyond Europe, turning down many offers of prestigious eponymous lectureships.

In 1992, at the age of 57, he was advised to remain off work on health grounds for up to six months. He took early retirement and moved to York, where he began a second career in medieval history, enrolling for an MA in history at York University. His thesis was entitled “Medical care in late medieval York.”

In 1996 he was appointed research associate (honorary) in the Centre for Medieval Studies at the University of York. He scanned documents that, until then, could be seen only by visitors to York and taught a speech recognition programme to recognise Latin. With modern technology he established unique databases for medieval Yorkshire wills and names, and other early documents. These databases, which go back to the 13th century, over 300 years before parish registers began, were then made available to other researchers throughout the world.

Predeceased by his wife, Shirley, he leaves five children.

Philip Michael Stell, former professor of otolaryngology University of Liverpool (b 1934; q Edinburgh 1958; FRCS, FRCS Ed, MBE), d 29 May 2004.
Acute Pharyngitis and Tonsillitis in University of Wisconsin Students
Authors: Alfred S. Evans, Elliot C. Dick
Journal: JAMA (1964)

An etiologic study of acute pharyngitistonsillitis in over 300 Universty of Wisconsin students hospitalized with the illness revealed that 26.3% of the cases were associated with hemolytic streptococci, 37.8% were associated with viruses, and 35.9% were of unknown cause. Herpes simplex was the viral agent most frequently implicated, accounting for 12.9% of the total. Other viruses involved were: adenovirus, 2.7%; Coxsackie, 3.9%; influenza, 5.2%; parainfluenza, 3.7%; combination of two viruses, 2.3%; and unidentified picornaviruses, 7.1%. Clinical analysis of illness associated with different etiologic entities, including the hemolytic streptococcus, did not reveal differences that could serve as reliable bases for differential diagnosis in individual patents.
Strahlenpathologie der Zelle: Beiträge zur Zyto- und Histopathologie der Strahlenwirkung
Authors: Kurt Stern
Journal: JAMA (1964)

The need for effective interdisciplinary communication is particularly urgent when rapid progress involves specialized methodology inaccessible to most workers in other fields. This symposium attempts to bridge the gap between radiobiology, concerned with diagnostic, therapeutic, and experimental utilization of ionizing radiation, and the morphologic and biochemical exploration of structural and ultrastructural changes attributable to these procedures. True to the title, the 16 authors have<i>not</i>presented comprehensive and definitive expositions but rather have made "contributions" which broadly survey their respective topics. Adequate bibliographies appended to each chapter and illustrations consisting of diagrams and well-reproduced photomicrographs help to accomplish this purpose. As is to be expected there is a good deal of emphasis on electron microscopy, autoradiography, and biochemical analysis. Contrary to the impression gained from the title, "Radiation Pathology of the Cell," only one third of the text is devoted to cellular and subcellular structures (nucleus, nucleolus, mitochondria, membranes). The
Nonsurgical Management of Extrahepatic Obstructive Jaundice
Authors: RICHARD A. KOZAREK
Journal: Annals of Internal Medicine (1982)

Surgical decompression of extrahepatic biliary obstruction carries a significant risk of morbidity and mortality, depending on both the cause of the obstruction and the underlying medical status of the patient. Because of this risk, a number of nonsurgical therapies have been developed that offer an alternative to conventional surgical procedures. These new and still-evolving techniques, including endoscopic papillotomy, biliary stenting, balloon dilation, endoprosthesis insertion, and various T-tube manipulations, have become viable alternatives for decompressing the biliary tree in certain jaundiced patients. With the increasing use and dissemination of such procedures, primary care physicians should become aware of their availability as well as their indications and limitations.
France uncovers plan to bypass tobacco laws
Authors: A. Dorozynski
Journal: BMJ (1996)

Strategic plans to side step antitobacco laws have been seized from the offices of R J Reynolds France, the French subsidiary of R J Reynolds Tobacco International. They were seized by a Paris judge after a complaint against the company.

Lengthy excerpts from the plans have now been published in the French daily newspaper Le Monde. The documents describe techniques to bypass legislation prohibiting or limiting tobacco advertising. This legislation includes what is known in France as the Evin law, after the former minister of health and social affairs Claude Evin.

One document, …
The Rule of Law and the Role of Psychiatry
Authors: Marjorie C. Meehan
Journal: JAMA (1968)

Don't let the rather formidable title discourage you from reading this book. Written by a Family Court judge, it is important not only for lawyers and psychiatrists but for all thoughtful citizens. Judge Polier obviously works not merely to make proper legal judgments but to help solve the problems of the families brought before her. Often frustrated by the lack of suitable facilities, by inadequate legislation, by the indifference or prejudice of the general public, she is not entirely discouraged. She has written this book to express some of her beliefs and hopes, especially in regard to furthering the cooperation between the courts and psychiatrists. After briefly considering the psychiatrist's conventional role of helping determine responsibility for criminal acts, Judge Polier discusses the much greater potential role in working with juvenile delinquency, family difficulties, correctional procedures, narcotics abuse, and other social problems. She points out that the law and courts
Physicians for the Developing World-Reply
Authors: Ronald E. Pust
Journal: JAMA (1984)

In Reply.—  We strongly agree with Dr Day's thesis that physicians must be able to relate to the needs of the societies in which they work and appreciate his examples, which illustrate our mutual view. Whenever sharing of US health manpower with underserved areas, domestic or international, is proposed, this question of professional suitability for such practice is raised1; it formed the topic of the middle 50% of our article.  However, now is the opportune time to move beyond this highly legitimate concern, since there is growing agreement among partner nations (be they considered agent or client) and international health agencies on the priorities and technologies1in Third World medical care. Agreement is also growing over the role of physicians in such care.2,3We chose to use the Community-Oriented Primary Care/Health for All rather than the biopsychosocial conceptualization of this consensus perspective.  More important than terminology is
Hypertensive Responses to Methyldopa
Authors: Robert J. Levine, Barry S. Strauch
Journal: New England Journal of Medicine (1966)

SEVERAL of the drugs currently employed in the management of arterial hypertension interfere with either the binding or the catabolism of norepinephrine in tissues. Administration of these drugs occasionally results in dangerous paradoxical pressor reactions. Thus, parenteral administration of guanethidine or, less commonly, of reserpine may, by suddenly releasing large amounts of norepinephrine from tissue stores, increase blood pressure.1 This is particularly apt to occur when tissue stores of norepinephrine are abnormally large, as in patients with pheochromocytomas or in those taking drugs that inhibit monoamine oxidase activity. Patients treated with such inhibitors are also susceptible to severe hypertensive attacks . . .
P147Protective effect of ubiquinone-10 and complex of precursors and modulator of its biosynthesis on heart under doxorubicin treatment
Authors: O Kuchmenko, A Burlaka, I Ganusevich
Journal: Cardiovascular Research (2014)

Doxorubicin is a potent anticarcinogenic drug that is widely used in practical oncology. Its use is accompanied by cardiotoxicity and toxicity to other tissues. Ubiquinone (CoQ) is an important electron and proton carrier, antioxidant, regulator of genes expression. Its biosynthesis may be inhibited under number of pathologies. The aim was to study the state of mitochondrial electron transport chain (ETC) components, CoQ content and redox state, superoxide anion radicals and NO production rates, and matrix metalloproteinase-2 and -9 activities in rat heart tissues under treatment with doxorubicin, CoQ10 medical, and complex preparation of precursors and modulator of CoQ biosynthesis. Doxorubicin was administrated intraperitoneally in dose of 2.2 mg/kg daily for 8 days. Experimental rats in addition to doxorubicin received per os α-tocopherol acetate, 4-hydroxybenzoic acid, and methionine (EPM complex) and CoQ10. Under doxorubicin treatment heart weight to body weight ratio decreased. Treatment with EPM complex and CoQ10 in addition to doxorubicin administration exerts a protective effect on heart cells' mitochondria, evidenced by restoration of electron transport in electron transport chain, which is expressed as decreased nitrile complexes formation with Fe-S-proteins and increased ubisemiquinone content. It should be stressed that the protective effects of EPM complex on mitochondrial electron transport chain under doxorubicin administration is on par with those of CoQ10. EPM complex and CoQ10 administration leads to normalization of NO content, superoxide-anion radicals generation, free radical lipid (conjugated dienes, TBA-reactive products) and protein peroxidation and activity of antioxidant enzyme systems (catalase, superoxidedismutase) under doxorubicin treatment. Concurrently, matrix metalloproteinase-2 and -9 activities are decreased, which gives evidence of lessened extracellular matrix destruction. CoQ10 appeared to be more efficient at this if compared to EPM complex. The expiremental data obtained may become the basis of development of approaches to correction of adverse effects of doxorubicin. These data may be used to substantiate the application of these biologically active substances within frameworks of complex treatment of oncological and cardiovascular pathologies.
Germany cuts funds for methadone treatment
Authors: H. Karcher
Journal: BMJ (1996)

Public health insurers in Germany are to cut back on their refunds for methadone treatment for heroin addicts. The largest of the insurers, Allgemeine Ortskrankenkasse (AOK), has said that from 1 April only current heroin addicts will be allowed to remain on a methadone treatment plan. The insurer's director in Hamburg, Karin Schwemin, said the new policy was intended to prevent abuse of its funds.

The city …
Abstract 1251: Repurposing antipsychotic drug Penfluridol for cancer treatment
Authors: Alok Ranjan, Sanjay K. Srivastava
Journal: Cancer Research (2014)

Abstract Repurposing of old drugs as new anti-cancer drugs is important as it can save time and cost of drug development. Penfluridol is a first generation, highly potent antipsychotic drug. In this study, we determined the anticancer effects of Penfluridol in pancreatic cancer cells. Penfluridol treatment inhibited the growth of Panc-1, BxPC-3 and AsPC-1 pancreatic cancer cells in a concentration-dependent manner. Panc-1 , BxPC-3 and AsPC-1 cells treated with Penfluridol exhibited apoptosis as evaluated by Annexin/FITC assay and cleavage of caspase-3 and PARP. Our results showed that Penfluridol treatment induced ER stress in pancreatic cancer cells through the up regulation of ER stress markers like Bip/Grp78, CHOP and IRE. Penfluridol treatment also induced autophagy in pancreatic cancer cells as observed by acridine orange assay. Western blot analysis of Panc-1, BxPC-3 and AsPC-1 cells treated with Penfluridol exhibited up regulation of autophagy markers like LC3B, and p62. Microscopic analysis revealed punctate LC3B after Penfluridol treatment in pancreatic cancer cells confirming autophagy. Further mechanistic studies are in progress to establish the role of ER stress and autophagy in pancreatic cancer cells and correlate it with cell growth suppression. [Supported in part by R01 grant CA129038 awarded by NIH.] Citation Format: Alok Ranjan, Sanjay K. Srivastava. Repurposing antipsychotic drug Penfluridol for cancer treatment. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1251. doi:10.1158/1538-7445.AM2014-1251
Decreased Insulin-Stimulated ATP Synthesis and Phosphate Transport in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Parents
Authors: Kitt F Petersen, Sylvie Dufour, Gerald I Shulman
Journal: PLoS Medicine (2005)

Background Insulin resistance is the best predictor for the development of type 2 diabetes. Recent studies have shown that young, lean, insulin-resistant (IR) offspring of parents with type 2 diabetes have reduced basal rates of muscle mitochondrial phosphorylation activity associated with increased intramyocellular lipid (IMCL) content, which in turn blocks insulin signaling and insulin action in muscle. In order to further characterize mitochondrial activity in these individuals, we examined insulin-stimulated rates of adenosine triphosphate (ATP) synthesis and phosphate transport in skeletal muscle in a similar cohort of participants. Methods and Findings Rates of insulin-stimulated muscle mitochondrial ATP synthase flux and insulin-stimulated increases in concentrations of intramyocellular inorganic phosphate (Pi) were assessed by 31P magnetic resonance spectroscopy (MRS) in healthy, lean, IR offspring of parents with type 2 diabetes and healthy, lean control participants with normal insulin sensitivity. IMCL content in the soleus muscle of all participants was assessed by 1H MRS. During a hyperinsulinemic-euglycemic clamp, rates of insulin-stimulated glucose uptake were decreased by approximately 50% in the IR offspring compared to the control participants (p = 0.007 versus controls) and were associated with an approximately 2-fold increase in IMCL content (p < 0.006 versus controls). In the control participants rates of ATP synthesis increased by approximately 90% during the hyperinsulinemic-euglycemic clamp. In contrast, insulin-stimulated rates of muscle mitochondrial ATP synthesis increased by only 5% in the IR offspring (p = 0.001 versus controls) and was associated with a severe reduction of insulin-stimulated increases in the intramyocellular Pi concentrations (IR offspring: 4.7% ± 1.9% versus controls: 19.3% ± 5.7%; p = 0.03). Insulin-induced increases in intramyocellular Pi concentrations correlated well with insulin-stimulated increases in rates of ATP synthesis (r = 0.67; p = 0.008). Conclusions These data demonstrate that insulin-stimulated rates of mitochondrial ATP synthesis are reduced in IR offspring of parents with type 2 diabetes. Furthermore, these IR offspring also have impaired insulin-stimulated phosphate transport in muscle, which may contribute to their defects in insulin-stimulated rates of mitochondrial ATP synthesis.
The Challenge of the Regional Medical Program
Authors: TINSLEY R. HARRISON
Journal: Annals of Internal Medicine (1968)

Editorials1 January 1968The Challenge of the Regional Medical ProgramTINSLEY R. HARRISON, M.D., F.A.C.P.TINSLEY R. HARRISON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-1-245 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs a consequence of the increasing tempo of medical research, life expectancy continues to advance. Older people need more medical care. Likewise, new discoveries often require many additional man-hours on the part of physicians, nurses, and technologists. The failure of health education to expand at the same rate as research has thus led to progressive lengthening of the time lag between the development of new knowledge and its application to the medical care of the general public.The major purpose of the Regional Medical Program is to narrow this gap. There is a possibility that this program may fail either... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: TINSLEY R. HARRISON, M.D., F.A.C.P.Affiliations: University of Alabama Medical Center Birmingham, Ala. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRegional Medical Programs in Search of a Mission 1 January 1968Volume 68, Issue 1Page: 245-247KeywordsLife expectancyMedical education ePublished: 1 December 2008 Issue Published: 1 January 1968 PDF downloadLoading ...