tbuckley/cabot-search huggingface dataset:
Thou Shalt Not Covet
Authors: Samuel Bigg
Journal: JAMA (1968)

To the Editor:—  Your recent editorials, Have a Heart and Change of Heart, generated much outpouring of adrenalin in many of your readers. The callous proposal of licensed private heart farms and the frivolous speculation about the effect of cardiac transplantation on popular lyrics are offensive to good taste. Problems of organ transplantation are too serious to be treated in such cavalier fashion.  As in the days of cannibalism, when a human being was a source of desirable flesh, so, in the future days of unrestrained organ transplantation, one human being may become a tempting source of organs to another. Could there be a stronger inducement to murder, genocide, or war than the prospect of replenishing depleted organbanks?  In order to forestall these grisly developments, strong moral indoctrination becomes necessary. I suggest that we augment the list of commandments by adding an Eleventh, Thou Shalt Not Covet Thy Neighbor's Viscera.
Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease
Authors: Wei Xiong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao, Hong Chen, De-Pei Li, Gregg E Homanics, John Peever, Kenner C Rice, Ling-gang Wu, Hui-Lin Pan, Li Zhang
Journal: Nature Neuroscience (2014)
Patients and Tablets
Authors: A. M. W. Porter
Journal: BMJ (1966)

p. 1482) questions the factual basis for my tentative conclusion (21 May, p. 1301) that general practice may be the most appropriate setting for conducting clinical trials.Two types of defaulting in respect of adherence to treatment schedules must be distinguished, and perhaps should have been distinguished in my original letter.The first group are the " overt defaulters," and the second the " occult defaulters."The former fail to complete the trial for reasons which are obvious to the doctor-for example, volunteering that they have stopped the tab- lets, leaving the district, failing to reattend, etc. Being readily identifiable, their presence can be allowed for in the final assessment.It is the " occult defaulters " who may, and probably usually do, invalidate a trial.This group, having persevered, may appear to the unwary to have been entirely consonant to the treatment schedule, but in fact they have been dissonant.If my figures are examined, bearing in mind this distinction, then it can be seen that out of 29 " completers " 22 (76%) were available for assessment, and that only three of these patients were suspected as being definite defaulters.Can these figures be matched by any hospital outpatient trial ?I am, etc., Camberley,
Enhanced IL-4 Receptor Signaling Promotes IgE-mediated Systemic Anaphylaxis and Impaired Tolerance to Food Antigens
Authors: C.B. Mathias, S.A. Hobson, M. Garcia-Lloret, G. Lawson, D. Poddighe, E. Freyschmidt, W. Xing, M.F. Gurish, T.A. Chatila, H.C. Oettgen
Journal: Journal of Allergy and Clinical Immunology (2011)
Acute hemodynamic effects of cigarette smoking in man assessed by systolic time intervals and echocardiography.
Authors: B D Rabinowitz, K Thorp, G L Huber, W H Abelmann
Journal: Circulation (1979)

Sixteen healthy subjects, ages 18-35 years, were studied in the supine position by means of systolic time intervals and echocardiography before and after smoking a high-nicotine cigarette (2.5 mg nicotine) and a tobacco cigarette of very low nicotine content (< 0.02 mg nicotine) to assess and compare the immediate effects upon left ventricular function.Smokers (n = 12) and nonsmokers (n = 4) behaved alike.High-and low-nicotine cigarettes both caused significant increases in heart rate, systolic and diastolic blood pressure and the triple product (systolic blood pressure X left ventricular ejection (LVET) X heart rate), prolonged LVETc and decreased the preejection period (PEP) and PEP/LVET.In addition, smoking a nicotine reference cigarette increased the echocar- diographically derived LV end-diastolic volume by 7.5%, augmented ejection fraction by 4%, while significantly enhancing mean normalized circumferential fiber shortening by 12.5% and mean normalized posterior wall velocity by 9%.Smoking a tobacco cigarette of ultra-low nicotine content resulted in com- parable increases in ejection fraction and mean circumferential fiber shortening, albeit on the basis of a signifi- cant decrease in end-systolic volume without alteration in end-diastolic volume.These data suggest that in the supine position smoking a high-nicotine cigarette acutely increases venous return and augments the principal determinants of myocardial oxygen consumption heart rate, contrac- tility, preload and afterload and that cigarette smoke may contain inotropic and chronotropic substances other than nicotine.CIGARETTE SMOKING has been linked epi- demiologically as a risk factor in the development of myocardial infarction and has been associated with an increase in sudden death among chronic cigarette con- sumers.',I The cause of this increased morbidity and mortality has not been established; among the factors under consideration are hypoxemia,3 enhanced cor-
Acute Effects of Insulin in the Control of VLDL Production in Humans: Implications for the insulin-resistant state
Authors: Gary F Lewis, George Steiner
Journal: Diabetes Care (1996)

The role of hyperinsulinemia in the pathogenesis of triglyceride (TG) and VLDL over-production in insulin-resistant states remains controversial. While studies in humans and animals have generally suggested that chronic hyperinsulinemia facilitates VLDL production, particularly in the presence of an abundant supply of substrate for VLDL synthesis, the majority of in vitro studies using cultured hepatocytes and hepatoma cell lines have demonstrated an acute inhibitory effect of insulin. Using radiolabeled VLDL tracers we have examined the acute effect of hyperinsulinemia on VLDL production in humans. We found a rapid suppression of plasma free fatty acid (FFA) levels in response to insulin and a consistent 50-60% insulin-induced suppression of both VLDL TG and VLDL apolipoprotein (apo) B in lean insulin-sensitive individuals. Elevation of plasma FFA levels by infusing heparin and Intralipid without hyperinsulinemia resulted in a marked increase in VLDL TG and VLDL apoB production. When the insulin-induced suppression of plasma FFA levels was prevented during hyperinsulinemia, VLDL TG production was still inhibited, although to a lesser extent than with insulin alone. We concluded from these findings that insulin suppresses VLDL production in insulin-sensitive humans partly by suppressing plasma FFA levels and partly by a non-FFA-mediated (perhaps direct hepatic) mechanism. In addition, we found that chronically insulin-resistant hyperinsulinemic obese individuals were resistant to this suppressive effect of insulin on VLDL apoB production, in keeping with similar findings by others performing in vitro experiments using cultured hepatocytes isolated from insulin-resistant or hyperinsulinemic rats. The relevance of these findings to the mechanism of hypertriglyceridemia associated with chronic insulin-resistant states in humans remains a matter of speculation. One hypothesis is that resistance to the normal suppressive effect of insulin, in association with other metabolic abnormalities associated with insulin resistance, may contribute to postprandial and postabsorptive hypertriglyceridemia.
23% of babies in England are delivered by caesarean section
Authors: Susan Mayor
Journal: BMJ (2005)

Rates of caesarean deliveries in England have increased slightly, according to figures published last week, which continued the long term trend of increasing medical intervention in child-birth. The NHS Maternity Statistics, England: 2003-04 , based on hospital episode statistics, showed that the rate of caesarean sections increased slightly from 22.0% in 2002-3 to 22.7%. The total number of births also rose by 5% to 593 …
Inherited Aminoacidopathies Demonstrating Vitamin Dependency
Authors: Leon E. Rosenberg
Journal: New England Journal of Medicine (1969)

TWO very old topics form the basis for this presentation: inherited disorders of amino acid metabolism; and the biochemical and clinical importance of vitamins. The former subject originated in Garrod's lectures in 1908,1 which formalized the concept of inborn errors of metabolism and dealt with three disorders involving amino acids: alcaptonuria, albinism and cystinuria. The concept of vitamins was introduced in 1912 by Funk,2 who used the word "vitamine" in his study of beriberi to refer to a postulated amine in rice polishings that was essential to life.Progress in both areas has accelerated rapidly during the past two decades. . . .
SCH 434: A new antihistamine/decongestant for seasonal allergic rhinitis
Authors: William W. Storms, Stephen F. Bodman, Robert A. Nathan, Paul Chervinsky, Charles H. Banov, Robert J. Dockhorn, Irene Jarmoszuk, Howard J. Zeitz, Stephen J. McGeady, Jacob L. Pinnas, Saul Greenstein
Journal: Journal of Allergy and Clinical Immunology (1989)
ASSOCIATION BETWEEN CARDIOVASCULAR RISK FACTORS AND THE PRESENCE AND EXTENT OF CORONARY ATHEROSCLEROTIC PLAQUE DETECTED BY MULTISLICE COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY
Authors: Hikmet Yorgun, Ergün B. Kaya, Tuncay Hazirolan, Ahmet H. Ateş, Sercan Okutucu, Uğur Canpolat, Hamza Sunman, Hakan Aksoy, Kadri M. Gürses, Kudret Aytemir, Giray Kabakçi, Lale Tokgö;zoğlu, Hilmi ö;zkutlu, Ali Oto
Journal: Journal of the American College of Cardiology (2010)
Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level
Authors: E Jones, S M Churchman, A English, M H Buch, E A Horner, C H Burgoyne, R Reece, S Kinsey, P Emery, D McGonagle, F Ponchel
Journal: Annals of the Rheumatic Diseases (2009)

Achieving joint regeneration in rheumatoid arthritis (RA) represents a future challenge. Autologous synovial mesenchymal stem cells (MSCs) could be therapeutically exploited. However, the inflammatory milieu in the RA synovium could adversely affect endogenous MSC function. To test this hypothesis, the frequency and multipotency of RA synovial MSCs was evaluated in relation to existing synovial inflammation.Synovial inflammation was measured using the arthroscopic visual analogue score (VAS) and further validated using immunohistochemistry and flow cytometry. Highly proliferative clonogenic in vivo MSCs were enumerated following fluorescence-activated cell sorting and expansion for 20 population doublings. MSC multipotency was quantified following standard in vitro culture expansion and trilineage differentiation assays. Real-time PCR, flow cytometry and ELISA were used to evaluate pro- and anti-chondrogenic molecules in standard polyclonal synovial MSCs.The arthroscopic VAS significantly correlated with synovial macrophage infiltration. In RA, synovial MSC chondrogenesis was inhibited in direct relation to VAS (r = -0.777, p<0.05) and reduced compared with control osteoarthritis (OA)-MSCs (p<0.05). In vivo, MSCs resided in the synovial fibroblastic/stromal fraction (CD45(-)CD31(-)) and were reduced in frequency in relation to VAS (r = -0.695, p<0.05). In RA-MSCs, CD44 levels correlated negatively with inflammation and positively with chondrogenesis (r = -0.830 and r = 0.865, respectively). Cytokine production and Sox9 expression was similar in RA-MSCs and OA-MSCs.There is a negative relationship between synovial MSC chondrogenic and clonogenic capacities and the magnitude of synovitis in RA. Effective suppression of joint inflammation is therefore necessary for the development of autologous MSC treatments aimed at cartilage regeneration in RA.
The Body as a Transitional Object
Authors: Mathias Hirsch
Journal: Psychotherapy and Psychosomatics (1994)

Review Articles| February 18 2010 The Body as a Transitional Object Subject Area: Psychiatry and Psychology Mathias Hirsch Mathias Hirsch Institut für Psychoanalyse und Psychotherapie, Düsseldorf, Deutschland Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1994) 62 (1-2): 78–81. https://doi.org/10.1159/000288907 Article history Published Online: February 18 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Mathias Hirsch; The Body as a Transitional Object. Psychother Psychosom 31 December 1994; 62 (1-2): 78–81. https://doi.org/10.1159/000288907 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1994Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
NUTRITIONAL MYOPATHY IN DUCKLINGS
Authors: Alwin M. Pappenheimer, Marianne Goettsch
Journal: The Journal of Experimental Medicine (1934)

Ducklings fed on a diet of skimmed milk powder, casein, corn-starch, lard, cod liver oil, yeast, salts and paper pulp rapidly develop a disease characterized by extreme and progressive myasthenia, ending in death within a few days. Pathological changes are found in the skeletal muscles. These show widespread hyaline necrosis of fibers, with edema and cellular reaction. The brain and other parts of the central nervous system are not affected, and no significant alterations are found in other viscera or tissues. The creatine content of the muscles is reduced in proportion to the muscle injury. Controls on a natural food diet remain free from the disease.
Deaths on the operating table
Authors: M. Jones
Journal: BMJ (2000)

The consequences of a patient dying during surgery have made headline news in the medical press recently. The message appeared unequivocal in the BMJ , Hospital Doctor , and BMA News Review . An operating list should stop if a patient dies on the operating table, and the surgeon should not operate for the rest of that day.

The BMJ reported Professor Sir Alfred Cuschieri as saying, “My own view is that the death on the operating table of the patient is a harrowing experience for a surgeon. In my view, the surgeon is emotionally and mentally not in the frame of mind to continue to operate that day.” It was also stated that the sheriff conducting the inquiry agreed with this view. The president of the Royal College of Surgeons of Edinburgh was also quoted as saying, “We can understand the pressure that single surgeons are under, but I …
Re-emergence of echovirus type 13 infections in 2002 in Yamagata, Japan
Authors: Katsumi Mizuta, Chieko Abiko, Toshio Murata, Tsutomu Itagaki, Noriko Katsushima, Tomoharu Akiba, Michiyo Sakamoto, Katsumi Ootani, Shoko Murayama
Journal: Journal of Infection (2003)
A Short Course of Prednisolone in Chronic Type B Hepatitis
Authors: JAY H. HOOFNAGLE
Journal: Annals of Internal Medicine (1986)

Fifteen patients with chronic type B hepatitis were treated with corticosteroids in a randomized, double-blind, placebo-controlled trial lasting 28 days. Ten patients received prednisolone, 60 mg/d for 2 weeks, then 30 mg/d for another 2 weeks; 5 patients received placebo. Serum aminotransferase levels decreased significantly during prednisolone therapy but 4 to 10 weeks after abrupt withdrawal of the drug, they rebounded to levels greater than those before treatment. This exacerbation of disease lasted for several months and was prolonged and symptomatic in 3 patients. Hepatitis B virus levels did not change substantially during treatment. Follow-up examinations showed no improvement in biochemical or serologic features of the disease in any of the 15 patients; follow-up liver biopsies showed a worsening in 4 of 7 treated patients but in 0 of 5 control patients. Thus, a 28-day course of prednisolone produced no beneficial effects in patients with mild-to-moderate chronic type B hepatitis; on the contrary, such treatment may be harmful.
Art: The Museum of Emotions
Authors: R. Persaud
Journal: BMJ (2000)

The Bargehouse, Oxo Tower Wharf, London, until 4 June 2000

Traditional museums house valuable objects. The Museum of Emotions , an art installation on London's South Bank, suggests that more subtle and abstract items might be worthy of an exhibition. The items are emotions themselves, presented in a series of rooms, with interactive exercises that evoke particular moods.

In between the rooms are regular “expression points” where signs suggest how we might articulate our feelings. One card says “Scream here.” Just after I had been bleeped about a psychiatric admission, I read the …
Genetic Characterization of Columnar Cellular Lesions and Atypical Ductal Hyperplasia of the Breast.
Authors: R. Ellsworth, J. Weyandt, J. Fantacone-Campbell, B. Deyarmin, D. Ellsworth, J. Hooke, C. Shriver
Journal: Cancer Research (2009)

Abstract Aims: Columnar cell lesions (CCL) and atypical ductal hyperplasia (ADH) frequently coexist and share molecular changes with in situ and invasive components, suggesting that CCL and ADH may be precursors to breast cancer. These conclusions are, however, largely based on studies examining CCL and/or ADH from patients diagnosed with more advanced disease. Thus, we assessed allelic imbalance (AI) in pure CCL or ADH specimens to characterize molecular changes in early breast lesions.Methods and results: DNA samples were obtained from laser microdissected lesions from CCL with (n=42) or with ADH (n=31) without concurrent in situ or invasive disease. AI was assessed at 26 chromosomal regions commonly altered in breast cancer. The average AI frequency was 6.2% (range 0-20%) in CCL and 6.1% (range 0-25%) in ADH with no significant difference in levels of AI between CCL and ADH. The highest levels of AI were on chromosomes 8q24 and 17q21 in ADH (23%) and CCL (15%), respectively.Conclusions: In conjunction with low overall levels of AI, chromosomal alterations that characterize low- and high-grade in situ and invasive disease were not frequent in pure CCL and ADH. Thus, pure lesions are not genetically advanced and are molecularly distinct from synchronous lesions. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5156.
Calcification of the Thoracic Aorta as Detected by Spiral Computed Tomography Among Stable Angina Pectoris Patients
Authors: Alon Eisen, Alexander Tenenbaum, Nira Koren-Morag, David Tanne, Joseph Shemesh, Massimo Imazio, Enrique Z. Fisman, Michael Motro, Ehud Schwammenthal, Yehuda Adler
Journal: Circulation (2008)

Calcification of the thoracic aorta is associated with atherosclerotic risk factors, yet its pathogenesis and clinical implications are not yet elucidated. The goal of the present study was to assess whether thoracic aorta calcification is associated with an increased risk of cardiovascular events and death in patients with stable angina pectoris.A prospective cohort of 361 stable angina pectoris patients (307 men, 54 women; age range, 37 to 83 years) underwent chest spiral computed tomography and were evaluated for aortic calcification. We recorded the incidence of cardiovascular events and death during a 4.5- to 6-year follow-up. Aortic calcification was documented in 253 patients (70% of patients; 213 men, 40 women). Patients with aortic calcification were older (mean age, 65+/-7 versus 55+/-9 years; P<0.001), and fewer were classified as smokers (13% versus 26%; P=0.014) compared with patients without aortic calcification. Significant correlation was found between patients with and those without aortic calcification for the presence of aortic valve calcification (28% versus 11%; P<0.001), mitral annulus calcification (29% versus 4%; P<0.001), and coronary calcification as expressed by coronary calcium score. (P<0.001). During 4.5 to 6 years of follow-up, 19 patients died, all of whom were in the aortic calcification group. Age-adjusted hazard ratios for total events and cardiovascular events by aortic calcification were 2.84 (95% CI, 1.52 to 5.30; P=0.001) and 2.70 (95% CI, 1.33 to 5.47; P=0.006), respectively. In multivariable analysis, hazard ratios for total events and cardiovascular events were 2.79 (95% CI, 1.46 to 5.20; P=0.002) and 4.65 (95% CI, 1.19 to 18.26; P=0.028), respectively.Calcification of the thoracic aorta is age related and associated with coronary calcification and valvular calcification. Thoracic aortic calcification is associated with an increased risk of death and cardiovascular disease.
Alterations in the Expression of the Genes Encoding Specific Muscarinic Receptor Subtypes in the Hypothalamus of Spontaneously Hypertensive Rats
Authors: Jian Wei, Antonio Milici, Jerry J. Buccafusco
Journal: Circulation Research (1995)

Abstract A significant body of evidence exists that is consistent with the possibility that heightened cholinergic activity in certain brain regions, such as the hypothalamus, leads to increased sympathetic tone and subsequent hypertension. The increase in cholinergic activity is mediated at least in part through enhanced sensitivity of muscarinic receptors. In this study, we used the technique of reverse transcriptase–polymerase chain reaction to estimate the relative levels of mRNA encoding the five known subtypes of muscarinic receptors within the hypothalamus of spontaneously hypertensive rats (SHR), a genetic model of the disease, and their normotensive counterparts (Wistar-Kyoto rats). SHR exhibited a significant increase (40% to 50%) in the excitatory M1 subtype (confirmed by receptor binding) and a decrease in the inhibitory M4 subtype of muscarinic receptors before and during the establishment of hypertension. Such alterations may form part of the genotypic profile of inherited hypertension.