tbuckley/cabot-search huggingface dataset:
Unusual Cases Involving the CNS and Nasal Sinuses
Authors: Vinay Raja, Gerald A. Campbell
Journal: Journal of Clinical Oncology (2003)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.03.061 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 14551308 Unusual Cases Involving the CNS and Nasal Sinuses CASE 2. SINONASAL UNDIFFERENTIATED CARCINOMA Vinay RajaxVinay RajaSearch for articles by this author , Gerald A. CampbellxGerald A. CampbellSearch for articles by this author Show More University of Texas Medical Branch, Galveston, TX https://doi.org/10.1200/JCO.2003.03.061 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
A PLEA FOR THE AGED.
Authors: J. W. BELL
Journal: JAMA (1899)

One of the saddest commentaries on the medicine of the past can truthfully be said to be the neglect of the aged, as indicated by the scanty literature on the subject and the general apathy existing in the profession relative to the study of the normal changes as well as the diseases peculiar to advanced life. To the profession of France largely belongs the honor of laying the foundation for whatever we possess, fragmentary though it be, of senile pathology. Prior to the beginning of this century those who wrote on the subject wrote, like Cicero, from a contemplative literary standpoint with the possible exception of the small treatises of Floyer, Welsted and Fisher. It remained for Pinel, in his elaborate treatise on "Clinical Medicine," published in 1815, the result of his vast experience in the Salpetrière Hospital, to furnish the nucleus of our present knowledge of senile pathol ogy.
Distinct role of adiposity and insulin resistance in glucose intolerance: Studies in ventromedial hypothalamic-lesioned obese rats
Authors: Asako Kageyama, Tsutomu Hirano, Haruaki Kageyama, Toshimasa Osaka, Yoshio Namba, Masatomi Tsuji, Mitsuru Adachi, Shuji Inoue
Journal: Metabolism (2002)
Desensitisation to allopurinol.
Authors: S M Kelsey, G R Struthers, T Beswick, D R Blake
Journal: Annals of the Rheumatic Diseases (1987)

Desensitisation to allopurinol SIR, Allopurinol is a highly effective, yet unique drug for the treatment of chronic gout.Mild allergic reactions are common, however, and in 5% of patients severe cutaneous reactions limit its use.'To date there are only three reports of desensitisation to allopurinol: two in patients with renal failure and one in a patient with severe chronic tophaceous gout.24We now report a case of successful desensitisation to allopurinol in a patient with chronic polyarticular gout and a history of cutaneous allopurinol hypersensitivity.The implications for wider use are discussed.
THE COMPARATIVE PHYSIOLOGY OF THE MENSTRUAL CYCLE
Authors: S. Zuckerman
Journal: BMJ (1932)

rrHEflSR'ITT.10 separated fractious derived from tuberculin or tubercle vaccines afforcds some encouragement.It has been shown by Sapin, Doan, anid Forkner that the lipid fractions of tuberculin lead, wheni injected, to proliferation of epithe- lioid cells, while Seibert has demonstrated that the protein fraction induces necrosis in a tuberculous animal and not in one free from that iinfection.Tuberculin and tubercle vaccines are powerful substances.It is certain that they can do harm.XVhat I hope may emerge from our discus- sion is a clear conception of the conditions under which they can be helpful.I am still hopeful that a real specific treatment will eventually be discovered on bacteriological lines, and I think the biochemists, with the bacteriologists, may eventully provide the solution of this difficult but fascinating problem.
Association of MHC antigens with susceptibility to and severity of rheumatoid arthritis in multicase families.
Authors: D J Walker, M Griffiths, P Dewar, E Coates, W C Dick, M Thompson, I D Griffiths
Journal: Annals of the Rheumatic Diseases (1985)

A study of HLA association with rheumatoid arthritis (RA) in multicase families has been performed in north east England. Two hundred and nineteen individuals from 13 families were assessed for the presence of RA, and all were HLA typed. Thirty-nine were found to have classical or definite RA by American Rheumatism Association (ARA) criteria. Thirty-five (90%) of these possess HLA-DR4, confirming the previously reported association of RA with DR4. A further 19 individuals were found to have probable RA or gave a convincing history of previous inflammatory polyarthritis. Thirteen (68%) of these possess HLA-DR4, and this is not significantly different from non-affected family members of whom 63% possess DR4. These results suggest that HLA-DR4 is associated only with the more severe forms of RA. Homozygosity for HLA-DR4 was not associated with either earlier onset or more severe disease when compared with heterozygous DR4. Possession of the haplotype most commonly inherited with the RA in individual families was not associated with earlier onset but may be associated with more severe disease. The severity of RA appears to be influenced by the major histocompatibility complex (MHC) in these families.
Relationship Between Gilbert Syndrome and Prevalence of Vascular Complications in Patients With Diabetes
Authors: Toyoshi Inoguchi, Shuji Sasaki, Kunihisa Kobayashi, Ryoichi Takayanagi, Tomomi Yamada
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regional differences in the expression of innate host defense molecules in sinonasal mucosa
Authors: Sudarshan Seshadri, Mariel Rosati, David C. Lin, Roderick G. Carter, James E. Norton, Andrew Wonho Choi, Lydia Suh, Atsushi Kato, Rakesh K. Chandra, Kathleen E. Harris, Hong Wei Chu, Anju T. Peters, Bruce K. Tan, David B. Conley, Leslie C. Grammer, Robert C. Kern, Robert P. Schleimer
Journal: Journal of Allergy and Clinical Immunology (2013)
Platelet activation and thrombosis: Studies in a patient with essential thrombocythemia
Authors: P. Nurden, C. Bihour, M. Smith, J.M. Raymond, A.T. Nurden
Journal: American Journal of Hematology (1996)

Recent advances permit the detection of activated platelets using specific monoclonal antibodies and flow cytometry. Nevertheless, there are few reports in which activated platelets have been studied over a period of time in patients at risk for thrombosis. Our patient S.D. has essential thrombocythemia and a prothrombotic state manifested in two major thrombotic episodes involving the portal vein and a mesenteric artery. Investigation revealed both spontaneous aggregation and hyperaggregability in response to ADP and the presence of activated platelets in platelet-rich plasma as revealed by flow cytometry. Interestingly, the activated platelets were recognized by an anti-RIBS ("receptor-induced binding site") monoclonal antibody that recognized bound fibrinogen but not by antibodies reactive with antigens whose presence on the platelet surface was secretion dependent. Treatment with aspirin inhibited spontaneous platelet aggregation but had little effect on the activated platelet profile. A change of therapy to ticlopidine suppressed expression of platelet activation markers. Treatment with ticlopidine has continued for 1 year so far without further thrombotic complications. © 1996 Wiley-Liss, Inc.
Rituximab in autoimmune bullous diseases: mixed responses and adverse effects
Authors: E. Schmidt, C.S. Seitz, S. Benoit, E.B. Bröcker, M. Goebeler
Journal: British Journal of Dermatology (2006)

Intolerably high doses of systemic corticosteroids and additional immunosuppressants may be required to control disease activity in autoimmune bullous skin diseases. New therapeutic options are needed for such patients.To determine the efficacy and adverse effects of adjuvant rituximab.Seven patients with refractory autoimmune blistering diseases (pemphigus vulgaris, PV, n = 4; bullous pemphigoid, BP, n = 2; mucous membrane pemphigoid, MMP, n = 1) were treated four times with rituximab at an individual dose of 375 mg m(-2) at weekly intervals.All lesions cleared in three patients (two PV, one BP), while they were reduced by more than 50% in three others (two PV, one BP). The concomitant immunosuppressive medication was reduced in five patients (four PV, one BP). The patient with MMP developed bilateral blindness while nasopharyngeal lesions resolved. Three patients (two BP, one PV) experienced severe adverse events including fatal pneumonia.Adjuvant B-cell depletion by rituximab is effective in otherwise therapy-resistant bullous autoimmune disorders but may be associated with substantial adverse effects including fatal outcomes.
Principles of Ambulatory Medicine
Authors: Harold Nachimson
Journal: JAMA (1983)

This is a major text of 1,200-plus pages that takes its place as a standard work in the field of ambulatory medicine. Regrettably, it is too large to be carried in one's coat pocket, for surely it would be used often. The text is purposely limited by the editors to adult ambulatory medicine and runs true to this promise. Family practitioners will find the book useful but restrictive since there is little pediatrics, ambulatory surgery, or obstetrics-gynecology. Consequently, generalists will need supplemental works. The text is uniquely organized into 15 broad divisions called "sections" and 199 chapters that run the course of the book. The chapters relate to the sections geographically rather than ideologically. The beginning of each chapter reveals a friendly outline of contents with appropriate page assignments. One may peruse the contents to see clearly what is of interest and quickly go to that part. The broad sections
Medicine in 1876: Being an Inquiry into the Effects of Experimental Researches on the Principles and Practice of Medicine
Authors: J. E. Morgan
Journal: BMJ (1876)

dulgences or the vicious habits of your patients ; which will enable you to resist the sacrifice of your convictions to the tyranny of dominant opinion, or the seductions of popularity; which, keeping vou conscious of your own infirmities and errors, will make you candid and gene- rous!to the infirmities and errors of your professional brethren; which will teach you " to admire without envy", and to suffer without bitter- ness; and which, lifting you above the highest region of human inte- rests and passions, and showing you how human freedom, like a " swimmer shaping his course in the stream which carries him along", is but a limited activity in the hands of overruling power, will place you in filial relations to the Eternal Mind.This is the spirit which you should strive to cultivate in yourselves, as one of the most precious results of the knowledge which you will acquire, and of the discipline which you will practise within these walls.This is the spirit which will redeem you from failure and be your sure support in every time of trouble.Wealth may fail, friends may fail, you yourselves may fail, but this spirit, living and fructifying in you, will never fail.In the hurry, the turmoil, and the conflicts of life; in fears that might dismay, and amid calamities that might over- whelm, it will abide with you and it will fill your hearts with the peace which passeth understanding-the peace which the world cannot give.
Identification of a permissible HLA mismatch in hematopoietic stem cell transplantation
Authors: Marcelo A. Fernandez-Viña, Tao Wang, Stephanie J. Lee, Michael Haagenson, Mahmoud Aljurf, Medhat Askar, Minoo Battiwalla, Lee-Ann Baxter-Lowe, James Gajewski, Ann A. Jakubowski, Susana Marino, Machteld Oudshoorn, Steven G. E. Marsh, Effie W. Petersdorf, Kirk Schultz, E. Victoria Turner, Edmund K. Waller, Ann Woolfrey, John Umejiego, Stephen R. Spellman, Michelle Setterholm
Journal: Blood (2014)
US is now "past the rhetoric" in fighting malaria worldwide
Authors: B. Roehr
Journal: BMJ (2009)

Elimination of malaria had been neglected for nearly half a century until speeches by Bill and Melinda Gates in October 2007 put it back on the agenda, the international public health expert Richard Feachem claimed at a 17 June gathering in Washington, DC, that focused on US strategy in combating malaria around the world.

“Their call to arms has changed the nature of the international discussion in a very positive way,” said Sir Richard, now director of the Global Health Group at the University of California, San Francisco.

The United States is moving from …
Lymphocyte subpopulations in essential mixed cryoglobulinaemia.
Authors: F Garcia-Bragado Dalmau, G Acebedo, M Biosca, M Villar, M Vilardell
Journal: Annals of the Rheumatic Diseases (1986)

Lymphocyte subpopulations in essential mixed cryoglobulinaemia SIR, Essential mixed cryoglobulinaemia (EMC) is an uncommon disease characterised by the formation of cryoprecipitable complexes involving IgM and IgG.' The
Partnership publishes data on patients who repeatedly use hospital services
Authors: Lisa Hitchen
Journal: BMJ (2006)

A new joint public-private scheme to provide data on the quality of health and social care services could end the NHS's poor record on using information about its own practices.

That was the message from the health minister Norman Warner at this week's launch of Dr Foster Intelligence, a partnership between the NHS's Health and Social Care Information Centre and the health research company Dr Foster.

The Department of Health has paid the private firm £12m ($21m; €18m) to set up the scheme, which will see 50% of profits going to its shareholders and 50% ploughed back into public services.

“We have got a lot of information in the public sector, but we are not always terribly good …
Information about infantile hemangiomas on the Internet: How accurate is it?
Authors: Karen Minzer-Conzetti, Maria C. Garzon, Anita N. Haggstrom, Kimberly A. Horii, Anthony J. Mancini, Kimberly D. Morel, Brandon Newell, Amy J. Nopper, Ilona J. Frieden
Journal: Journal of the American Academy of Dermatology (2007)
Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
Authors: Jae Geun Kim, Shigetomo Suyama, Marco Koch, Sungho Jin, Pilar Argente-Arizon, Jesús Argente, Zhong-Wu Liu, Marcelo R Zimmer, Jin Kwon Jeong, Klara Szigeti-Buck, Yuanqing Gao, Cristina Garcia-Caceres, Chun-Xia Yi, Natalina Salmaso, Flora M Vaccarino, Julie Chowen, Sabrina Diano, Marcelo O Dietrich, Matthias H Tschöp, Tamas L Horvath
Journal: Nature Neuroscience (2014)
Visualization of Breast Tissue by Technetium-99m Labeled Dextran in Chronic Cystic Mastitis
Authors: KUANG-TAO A. YANG, CHUNG-CHIENG WU, JIN-YEH CHEN
Journal: Clinical Nuclear Medicine (1989)

A 42-year-old woman with history of chronic cystic mastitis was referred for lymphoscintigraphy to evaluate low back pain with swelling and soreness over the lower limbs. Lymphoscintigraphy was performed through bipedal intradermal injection of Tc-99m labeled dextran. Uptake of Tc-99m labeled dextran in breast tissue was incidentally identified.
Both heterozygous and homozygous α+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
Authors: Thomas N. Williams, Sammy Wambua, Sophie Uyoga, Alex Macharia, Jedidah K. Mwacharo, Charles R. J. C. Newton, Kathryn Maitland
Journal: Blood (2005)
Current evidence shows no place for antiviral drug distribution in a flu pandemic
Authors: P. J. Saunders, J. Middleton
Journal: BMJ (2014)

The BMJ and Cochrane Collaboration showed serious generic failings in the system of publishing full trial evidence about oseltamivir for flu.1 We remain concerned, however, that the insights of service providers during the 2009-10 pandemic have not been given the same public consideration.2

Even the selective evidence available in 2009 cannot justify the financial and public health …
Abnormalities of cardiac sympathetic function in pacing-induced heart failure as assessed by [123I]metaiodobenzylguanidine scintigraphy.
Authors: W W Simmons, M R Freeman, E A Grima, T W Hsia, P W Armstrong
Journal: Circulation (1994)

BACKGROUND Increased activity of the sympathetic nervous system contributes significantly to the pathophysiology of heart failure. However, cardiac efferent sympathetic function has not been well characterized in this disorder. In this study, we evaluated cardiac sympathetic innervation using [123I]metaiodobenzylguanidine (MIBG) and compared this with left ventricular (LV) tissue norepinephrine concentration and myocardial perfusion, assessed by 201Tl, in a canine model of heart failure. METHODS AND RESULTS Planar and tomographic cardiac imaging was performed for MIBG and 201Tl in 23 dogs: 8 normal dogs (group 1) and 15 dogs with heart failure induced by right ventricular pacing at 250 beats per minute either continuously for 3 weeks (group 2) or intermittently for 7 weeks (group 3). Plasma and LV tissue norepinephrine concentrations were also measured. Scintigraphic studies in group 2 demonstrated reduced cardiac MIBG activity at heart failure (0.17 +/- 0.04 versus 0.29 +/- 0.05 counts per megabecquerel per pixel at baseline, mean +/- SD; P = .0001), whereas thallium activity was unchanged from baseline. This reduction in cardiac MIBG activity with heart failure was associated with increased intraimage variability in the distribution of MIBG activity (21 +/- 8% versus 13 +/- 7% at baseline, mean +/- SD; P = .0001). The MIBG heart-to-lung ratio was calculated for all groups to control for the inhibitory effect that plasma norepinephrine has on the neuronal uptake of MIBG. There was a positive correlation between LV tissue norepinephrine and the MIBG heart-to-lung ratio (r = .67; P &lt; .001; n = 22), for which the group 2 heart failure animals had the lowest values. No relation existed between plasma norepinephrine concentration and the MIBG heart-to-lung ratio. In addition, regional LV tissue norepinephrine concentration and MIBG activity were both lowest at the apex in normal (group 1) and heart failure (group 2) dogs. The MIBG heart-to-lung ratio also correlated inversely with cardiac filling pressure (r = -.59; P &lt; .05) and heart rate (r = -.65; P &lt; .01) and positively with cardiac output (r = .53; P &lt; .05). CONCLUSIONS Heart failure is associated with severe cardiac adrenergic dysfunction manifested by reduced MIBG activity and increased heterogeneity in the LV distribution of MIBG. Furthermore, MIBG scintigraphy is a simple noninvasive method for assessing global and regional LV tissue norepinephrine levels.
Pregnancy and PTU
Authors: David H. Solomon
Journal: New England Journal of Medicine (1981)

In this issue of the Journal Cheron et al. report that modest doses of propylthiouracil (PTU) ingested by mothers being treated for Graves' disease significantly reduce serum thyroxine in newborn infants.This finding is an important extension of previous observations. It has long been known that PTU crosses the placenta and is active against the fetal thyroid. Furthermore, many studies have shown that maternal thyroxine (T4) and triiodothyronine (T3) are in effect barred from reaching the fetal circulation except at extremely high maternal serum concentrations.1 Thus, overt fetal hypothyroidism and goiter result from large doses of . . .
Secondary Sphere Formation Enhances the Functionality of Cardiac Progenitor Cells
Authors: Hyun Jai Cho, Ho Jae Lee, Seock Won Youn, Seok Jin Koh, Joo Yun Won, Yeon Ju Chung, Hyun Ju Cho, Chang Hwan Yoon, Sae Won Lee, Eun Ju Lee, Yoo Wook Kwon, Hae Young Lee, Sang Hun Lee, Won Kyung Ho, Young Bae Park, Hyo Soo Kim
Journal: Molecular Therapy (2012)

Loss of cardiomyocytes impairs cardiac function after myocardial infarction (MI). Recent studies suggest that cardiac stem/progenitor cells could repair the damaged heart. However, cardiac progenitor cells are difficult to maintain in terms of purity and multipotency when propagated in two-dimensional culture systems. Here, we investigated a new strategy that enhances potency and enriches progenitor cells. We applied the repeated sphere formation strategy (cardiac explant → primary cardiosphere (CS) formation → sphere-derived cells (SDCs) in adherent culture condition → secondary CS formation by three-dimensional culture). Cells in secondary CS showed higher differentiation potentials than SDCs. When transplanted into the infarcted myocardium, secondary CSs engrafted robustly, improved left ventricular (LV) dysfunction, and reduced infarct sizes more than SDCs did. In addition to the cardiovascular differentiation of transplanted secondary CSs, robust vascular endothelial growth factor (VEGF) synthesis and secretion enhanced neovascularization in the infarcted myocardium. Microarray pathway analysis and blocking experiments using E-selectin knock-out hearts, specific chemicals, and small interfering RNAs (siRNAs) for each pathway revealed that E-selectin was indispensable to sphere initiation and ERK/Sp1/VEGF autoparacrine loop was responsible for sphere maturation. These results provide a simple strategy for enhancing cellular potency for cardiac repair. Furthermore, this strategy may be implemented to other types of stem/progenitor cell-based therapy.
Hundreds of doctors to be investigated for questionable prescribing practices
Authors: M. McCarthy
Journal: BMJ (2013)

An investigation into physicians’ prescribing practices through Medicare’s drug benefit plan Medicare Part D has identified more than 700 physicians who have “extremely” unusual practices—including writing suspiciously high numbers of prescriptions, often for Schedule II and III drugs.

Schedule II drugs include methadone, oxycodone, and fentanyl, and Schedule III drugs include products that combine non-prescription analgesics, such as paracetamol, with lower dosages of hydrocodone and codeine. Overprescription of these substances is seen as the major cause of the increasing abuse of prescription drugs in the United States.

The investigation was conducted by …