Ranitidine and Theophylline
Authors: ELIZABETH FERNANDES
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 March 1984Ranitidine and TheophyllineELIZABETH FERNANDES, M.D., F. MICHAEL MELEWICZ, M.D.ELIZABETH FERNANDES, M.D.Search for more papers by this author, F. MICHAEL MELEWICZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-3-459_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The newly available histamine (H2) receptor antagonist, ranitidine hydrochloride (Zantac; Glaxo Inc. , Fort Lauderdale, Florida) has been approved for short-term treatment of duodenal ulcer. Ranitidine is four to eight times more potent than Cimetidine for inhibiting gastric acid secretions (1). As the use of ranitidine increases, reports of its interaction with other drugs such as warfarin and metoprolol are appearing (2). We report a case of theophylline toxicity induced by toxic elevation of serum theophylline levels after initiation of ranitidine therapy.A 75-year-old man with a history of chronic obstructive pulmonary disease with bronchospasm, peptic ulcer...References1. RANITIDINE (Zantac). Med Lett Drugs Ther. 1982;24:111-3. MedlineGoogle Scholar2. SPAHNMUTSCHLERKIRCHOHNHAUSJANISCH HEWEH. Influence of ranitidine on plasma metoprolol and antenolol concentrations Br Med J [Clin Res]. 1983;286:1546-7. CrossrefMedlineGoogle Scholar3. WEINBERGERSMITHMILAVETZHENDELES MGGL. Decreased theophylline clearance due to Cimetidine [Letter]. N Engl J Med. 1981;304:672. CrossrefMedlineGoogle Scholar4. REITBERGBERNHARDSCHENTAG DHJ. Alteration of theophylline clearance and half-life by Cimetidine in normal volunteers. Ann Intern Med. 1981;95:582-5. LinkGoogle Scholar5. MCCARTHY D. Ranitidine or Cimetidine [Editorial]. Ann Intern Med. 1983;99:551-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Permanente Medical Group Martinez, CA 94553 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug Interactions with Agents Used to Treat Gastrointestinal DiseaseDrug Interactions with Agents Used in Respiratory DiseaseEffects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitisTreatment of theophylline overdoseEffect of Ranitidine on Theophylline Metabolism in Healthy Koreans Living in ChinaHEPATOTOXICITY OF DRUGS USED IN THE TREATMENT OF GASTROINTESTINAL DISORDERSTheophylline toxicityComparative Investigation of the Influence of Nizatidine, Ranitidine, and Cimetidine on the Steady-State Pharmacokinetics of Theophylline in COPD PatientsRanitidine treatment and cortisol metabolism in manDrug-Drug Interactions with H2-Receptor AntagonistsThe drug interaction potential of ranitidine: An updateRanitidine—Theophylline Interaction—Fact or Fiction?Histamine 2 -Receptor AntagonistsEffects of famotidine and cimetidine on plasma levels of epidurally administered lignocaineInteraction of tertatolol with rifampicin and ranitidine pharmacokinetics and antihypertensive activityEffect of cimetidine and ranitidine on plasma theophylline in patients with chronic obstructive airways disease treated with theophylline and corticosteroidsEffects of equimolar doses of cimetidine and ranitidine on theophylline eliminationTheophylline toxicity subsequent to ranitidine administration: A possible drug-drug interactionA comparison of the influence of famotidine and cimetidine on phenytoin elimination and hepatic blood flow.Induction of theophylline toxicity and inhibition of clearance rates by ranitidineSafety perspectives on parenteral H2-receptor antagonistsCimetidine and ranitidine on basal and ACTH-stimulated steroidogenesis.Clinically Important Adverse Effects and Drug Interactions with H 2 -Receptor Antagonists: An UpdateAccidents psychiques liés à l'inhibition du catabolisme des benzodiazépinesH2-receptor antagonists as inhibitors of oxidative drug metabolism in vivoRanitidine drug interactions—a literature reviewThe Hepatic and Renal Mechanisms of Drug Interactions with CimetidineRanitidine and TheophyllineMARIE E. GARDNER, Pharm.D., GERLAD W. SIKORSKI, D.O.Antacids and Theophylline-Ranitidine InteractionELIZABETH FERNANDES, M.D., F. MICHAEL MELEWICZ, M.D.Ranitidine and TheophyllineJOEL H. DOBBS, PHARM.D., M.P.H., ROBERT N. SMITH, M.D. 1 March 1984Volume 100, Issue 3Page: 459-459KeywordsChronic obstructive pulmonary diseaseDrug interactionsDrugsDuodenal ulcersHistaminePeptic ulcersTheophylline toxicity Issue Published: 1 March 1984 PDF downloadLoading ...