Cholestatic Jaundice Associated with Flurazepam Hydrochloride
Authors: MARY H. FANG
Journal: Annals of Internal Medicine (1978)

Brief Reports1 September 1978Cholestatic Jaundice Associated with Flurazepam HydrochlorideMARY H. FANG, M.D., ALLEN L. GINSBERG, M.D., WILLIAM O. DOBBINS III, M.D.MARY H. FANG, M.D.Search for more papers by this author, ALLEN L. GINSBERG, M.D.Search for more papers by this author, WILLIAM O. DOBBINS III, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-3-363 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFlurazepam hydrochloride (Dalmane®), a commonly used hypnotic available since 1970, has not previously been linked with hepatic toxicity (1). We report here the case of a patient with jaundice associated with flurazepam hydrochloride.A 70-year-old white man was admitted on 5 September 1977 with a 2½-month history of anorexia, weakness, and fatigue. Two and one-half weeks before admission, he had noticed brown urine and clay-colored stools. Pruritis and jaundice had occurred 1 week later. He denied abdominal pain and significant weight loss. A cholecystectomy and an appendectomy had been done in 1969 and coronary artery bypass in 1972. He now...References1. GREENBLATTSHADERKOCH-WESER DRJ: Flurazepam hydrochloride, a benzodiazepine hypnotic. Ann Intern Med 83:237-241, 1975 LinkGoogle Scholar2. KLATSKIN G: Toxic and drug-induced hepatitis, in Diseases of the Liver, 4th ed., edited by SCHIFF L. Philadelphia, J. B. Lippincott Company, 1975, p. 680 Google Scholar3. ABBRUZZESESWANSON AJ: Jaundice after therapy with chlordiazepoxide hydrochloride. N Engl J Med 273:321-322, 1965 CrossrefMedlineGoogle Scholar4. CACIOPPOMERLIS JS: Chlordiazepoxide hydrochloride (Librium) and jaundice: report of a case. Am J Psychiatry 117:1040-1041, 1961 CrossrefMedlineGoogle Scholar5. FRANKSJACOBS EW: Cholestatic jaundice possibly due to benzodiazepine-type drugs. Mo Med 72:605-606, 1975 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: George Washington University School of Medicine and Health Sciences Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLiver damage in children with acute poisoning due to psychopharmacological drugsBenzodiazepinesPsychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicityHepatotoxicity of Psychotropic Drugs and Drugs of AbuseHepatotoxicity of psychotropic drugsBentazepam-Induced Hepatic Bridging NecrosisElevation of serum aminotransferases during S-adenosyl-L-methionine treatment for possible drug-induced cholestasisAcute Drug-Induced Hepatic Injury9 Drug-induced cholestasisDrug-Induced CholestasisDrug effects on the liverDrugs and Liver Disease: A Tabular Compilation of Drugs and the Histopathological Changes That Can Occur in the LiverGastrointestinal DisordersToxicology and Side-Effects of AnxiolyticsDrug effects on the liver 1 September 1978Volume 89, Issue 3Page: 363-364KeywordsAbdominal painAppendectomyCholecystectomyCoronary arteriesFatiguePruritusToxicityUrineWeight loss Issue Published: 1 September 1978 PDF DownloadLoading ...