Renal Tubular Acidosis, Hypokalemia, and Acid Phosphatase
Authors: MYRON R. SCHOENFELD
Journal: Annals of Internal Medicine (1966)

Case Studies1 December 1966Renal Tubular Acidosis, Hypokalemia, and Acid PhosphataseMYRON R. SCHOENFELD, M.D., F.A.C.P., STEPHEN GULOTTA, M.D.MYRON R. SCHOENFELD, M.D., F.A.C.P.Search for more papers by this author, STEPHEN GULOTTA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-6-1256 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe most common pathologic findings (hematoxylin and eosin stain) in the human nephron in hypokalemic nephropathy are vacuolization or granulation or both of proximal convoluted tubules, distal tubules being less affected (1-3); this is a pattern apparently constant regardless of the cause of potassium loss. The nature of these vacuoles and granules is not clear. Because staining techniques have shown that they do not contain glycogen or lipid and because potassium depletion in experimental animals often increases the number of renal lysosomes (1-3), it has been suggested that perhaps they are lysosomes.The admission of a patient with hypokalemia associated...References1. MUEHRCKEROSEN RCS: Hypokalemic nephropathy in rat and man: a light and electron microscopic study. Lab. Invest. 13: 1359, 1964. MedlineGoogle Scholar2. WACHSTEINMEISEL ME: Enzymatic staining reactions in the kidneys of potassium-depleted rats. Amer. J. Path. 35: 1189, 1959. MedlineGoogle Scholar3. MORRISONPANNERGASIC ABBG: Lysosomes in the renal papillae of rats: formation induced by potassium-deficient diet. Science 142: 1066, 1963. CrossrefMedlineGoogle Scholar4. GUTMANGUTMAN EBAB: Estimation of acid phosphatase activity of blood serum. J. Biol. Chem. 136: 201, 1940. CrossrefGoogle Scholar5. GOMORI G: Microscopic Histochemistry: Principles and Practice. University of Chicago Press, Chicago, 1952, p. 273. Google Scholar6. WACHSTEIN M: Histochemical staining reactions of the normally functioning and abnormal kidney. J. Histochem. Cytochem. 3: 246, 1955. CrossrefMedlineGoogle Scholar7. COUPLAND RE: The anatomy of the human kidney, in Renal Disease, edited by BLACK, D. A. K. F. A. Davis Co., Philadelphia, 1962, p. 25. Google Scholar8. WACHSTEINMEISELORTIZ MEJ: Intracellular localization of acid phosphatase as studied in mammalian kidneys. Lab. Invest. 11: 1243, 1962. MedlineGoogle Scholar9. YAFFECRAIGFELLERS SJJMFX: Studies on renal enzymes in a patient with renal tubular acidosis. Amer. J. Med. 29: 168, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mount Vernon and New York, New YorkFrom the Departments of Medicine, Mt. Vernon Hospital, Mt. Vernon, N. Y., and Lincoln Hospital, New York, N. Y.Requests for reprints should be addressed to M. R. Schoenfeld, M.D., 11 Bronx Rd., Yonkers, N. Y. 10704. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTissue antigens in normal and pathologic urine samples: A review 1 December 1966Volume 65, Issue 6Page: 1256-1259KeywordsGlycogensGratitudeHospital medicineLipidsLysosomesNephronsPhosphatasesPotassiumPyelonephritisStaining Issue Published: 1 December 1966 PDF downloadLoading ...