Sudden-Onset Thrombocytopenia with Oxaliplatin
Authors: Frederick G. Dold, Edith P. Mitchell
Journal: Annals of Internal Medicine (2003)

Letters15 July 2003Sudden-Onset Thrombocytopenia with OxaliplatinFrederick G. Dold, MD and Edith P. Mitchell, MDFrederick G. Dold, MDKimmel Cancer Center, Thomas Jefferson University Hospital; Philadelphia, PA 19107 (Dold, Mitchell) and Edith P. Mitchell, MDKimmel Cancer Center, Thomas Jefferson University Hospital; Philadelphia, PA 19107 (Dold, Mitchell)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-2-200307150-00021-w3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Oxaliplatin is a third-generation platinum compound that has shown activity in colorectal cancer. Although it has been used for several years in Europe, it has been approved for use in the United States only since 9 August 2002. With this approval, widespread use is anticipated. Two previous published reports described thrombocytopenia and hemolytic anemia thought to be caused by oxaliplatin (1, 2).Objective: To describe a case of sudden-onset thrombocytopenia in a patient taking oxaliplatin.Case Report: In June 2002, a 70-year-old woman with colon cancer metastatic to the liver presented for her 19th cycle of ...References1. Earle CC, Chen WY, Ryan DP, Mayer RJ. Oxaliplatin-induced Evan's syndrome [Letter]. Br J Cancer. 2001;84:441. [PMID: 11161414] CrossrefMedlineGoogle Scholar2. Sorbye H, Bruserud Y, Dahl O. Oxaliplatin-induced haematological emergency with an immediate severe thrombocytopenia and haemolysis. Acta Oncol. 2001;40:882-3. [PMID: 11859992] CrossrefMedlineGoogle Scholar3. Clinical investigator's brochure SR96669. New York: Sanofi; 1998:79. Google Scholar4. Dold F, Hoey D, Carberry M, Musket A, Freidberg V, Mitchell E. Hypersensitivity in patients with metastatic colorectal carcinoma undergoing chemotherapy with oxaliplatin [Abstract]. Proceedings of the American Society of Clinical Oncology. 2002; 21:370a. Abstract no. 1478. Google Scholar Author, Article, and Disclosure InformationAffiliations: Kimmel Cancer Center, Thomas Jefferson University Hospital; Philadelphia, PA 19107 (Dold, Mitchell) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCase Report: Oxaliplatin-Induced Immune-Mediated ThrombocytopeniaOxaliplatin Immune-Induced Syndrome Occurs With Cumulative Administration and Rechallenge: Single Institution Series and Systematic Review StudyOxaliplatin-induced immune-mediated cytopenias: A case report and literature reviewDisseminated Intravascular Coagulation and Immune Hemolytic Anemia, Possibly Evans Syndrome, After Oxaliplatin and Bevacizumab Infusion for Metastatic Colon Adenocarcinoma: A Case Report and Literature ReviewHypersensitivity reactions associated with oxaliplatin and their clinical managementOxaliplatin-induced Acute Thrombocytopenia: A Case Report and Review of the LiteratureOxaliplatin-induced acute-onset thrombocytopenia and hemorrhage: Case report and review of the literatureOxaliplatin-induced acute thrombocytopeniaHemolytic uremic syndrome induced by infusion of oxaliplatin: A case reportHypersensitivity reaction and acute immune-mediated thrombocytopenia from oxaliplatin: two case reports and a review of the literatureImmune-mediated pancytopenia induced by oxaliplatin: a case reportOxaliplatin-Mediated Increase in Spleen Size As a Biomarker for the Development of Hepatic Sinusoidal InjuryAcute Immune-Mediated Thrombocytopenia Due to Oxaliplatin Administration: A Case ReportTWO CASES OF DRUG-INDUCED THROMBOCYTOPENIA RESULTING FROM SENSITIVITY TO OXALIPLATINA Case of Autoimmune Hemolytic Anemia Caused by Repeated Administration of OxaliplatinOxaliplatin-Induced Immune Thrombocytopenia: Another Cumulative Dose-Dependent Side Effect?Portal Hypertension Associated With Oxaliplatin Administration: Clinical Manifestations of Hepatic Sinusoidal InjuryOxaliplatin-Mediated Autoimmune ThrombocytopeniaOxaliplatin-induced immune hemolytic anemia: a case report and review of the literatureOxaliplatin-Induced Haemolytic Anaemia: A Case ReportHemolytic uremic syndrome following the infusion of oxaliplatin: case reportOxaliplatin-induced immune thrombocytopeniaOxaliplatin-induced immune pancytopenia 15 July 2003Volume 139, Issue 2Page: W-59KeywordsAntibodiesBloodChemotherapyColorectal cancerHemoglobinHemolytic anemiaHeparinHeparin-induced thrombocytopeniaHypersensitivityPlatelets ePublished: 15 July 2003 Issue Published: 15 July 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...