Generalized Vaccinia in a Patient with Chronic Lymphocytic Leukemia and Hypogammaglobulinemia
Authors: JOHN E. ULTMANN
Journal: Annals of Internal Medicine (1964)

Case Studies1 October 1964Generalized Vaccinia in a Patient with Chronic Lymphocytic Leukemia and HypogammaglobulinemiaJOHN E. ULTMANN, M.D., F.A.C.P.JOHN E. ULTMANN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-728 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe reaction to smallpox vaccination is usually trivial and self-limited. Of five million people vaccinated in New York City in 1947, only seven, having no antecedent eczema, developed generalized vaccinia, an incidence of 1: 710,000 vaccinations (1). In 1953, the year following Bruton's (2) description of agammaglobulinemia, Keidan, McCarthy, and Haworth (3) reported a case of generalized vaccinia in an infant with absence of serum gamma globulin. Two, possibly three adults with secondary hypogammaglobulinemia due to chronic lymphocytic leukemia or lymphocytic lymphosarcoma have been reported to develop generalized vaccinia following smallpox vaccination (4-6). The present additional case is presented to...References1. GREENBERG M: Complication of vaccination against smallpox. Amer. J. Dis. Child. 76: 492, 1948. MedlineGoogle Scholar2. BRUTON OC: Agammaglobulinemia. Pediatrics 9: 722, 1952. CrossrefMedlineGoogle Scholar3. KEIDANMCCARTHYHAWORTH SEKJC: Fatal generalized vaccinia with failure of antibody production and absence of serum gamma globulin. Arch. Dis. Child. 28: 110, 1953. CrossrefMedlineGoogle Scholar4. OLANSKYSMITHHANSEN-PRUSS SJGOC: Fatal vaccinia associated with cortisone therapy. JAMA 162: 887, 1956. CrossrefMedlineGoogle Scholar5. ERICHSONMCNAMARA RBMJ: Vaccinia gangrenosa. Ann. Intern. Med. 55: 491, 1961. LinkGoogle Scholar6. CONYBEARE ET: Reports of the Chief Medical Officer of Health, Part II, 1949-1950, p. 26. 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BIGLERSLOTKOWSKI JAEL: Smallpox vaccination with prolonged vaccinia. Pediatrics 7: 24, 1951. MedlineGoogle Scholar20. KOZINNSIGELGORRIE PJMMR: Progressive vaccinia associated with agammaglobulinemia and defects in immune mechanism. Pediatrics 16: 600, 1955. MedlineGoogle Scholar21. CONNOLLYDICKFIELD JHGWCM: A fatal case of progressive vaccinia. Brit. Med. J. 5288: 1315, 1962. CrossrefGoogle Scholar22. WHITE CM: Vaccinia gangrenosa due to hypogammaglobulinaemia. Lancet 1: 969, 1963. CrossrefMedlineGoogle Scholar23. FLEWETTKER THFL: A case of vaccinia necrosum (or progressive vaccinia), with severe hypogammaglobulinaemia, treated with N-methyl isatin beta-thiosemicarbazone (33T57). J. Clin. Path. 16: 271, 1963. CrossrefMedlineGoogle Scholar24. KEMPE CH: Personal communication. 1963. Google Scholar25. KABAT EA: Use of hyperimmune human gamma globulin. New Eng. J. Med. 269: 247, 1963. CrossrefMedlineGoogle Scholar26. BAUERVINCENTKEMPEDOWNIE DJLSCHAW: Prophylactic treatment of smallpox contacts with N-methylisatin betathiosemicarbazone (compound 33T57, Marboran). Lancet 2: 494, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN E. ULTMANN, M.D., F.A.C.P.Affiliations: New York, New YorkFrom the Department of Medicine, Columbia University College of Physicians and Surgeons and Francis Delafield Hospital, New York City, N. Y.This work was supported in part by grant CA-02332 from the U. S. Public Health Service, National Cancer Institute, and in part by the Anne Winton Memorial Fund and the Health Research Council of the City of New York.Requests for reprints should be addressed to John E. Ultmann, M.D., Institute of Cancer Research, College of Physicians and Surgeons of Columbia University, 630 West 168 St., New York, N. Y. 10032. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProgressive VacciniaInfection and Immunity in Chronic Lymphocytic LeukemiaLeukämienThe Clinical Features of Chronic Lymphocytic LeukaemiaAdrenal glucocorticoids after twenty yearsInfluence and production of interferon in Rauscher virus infected mice 1 October 1964Volume 61, Issue 4 Page: 728-732 Keywords Chronic lymphocytic leukemia Hospital medicine Infants Infectious hepatitis Libraries Medical services Proteins Smallpox Surgeons Ulcers ePublished: 1 December 2008 Issue Published: 1 October 1964 PDF downloadLoading ...