tbuckley/cabot-search huggingface dataset:
Regulation of Aldosterone Biosynthesis by Adrenal Renin Is Mediated Through AT <sub>1</sub> Receptors in Renin Transgenic Rats
Authors: Massimo Volpe, Speranza Rubattu, Bruna Gigante, Detlev Ganten, Antonio Porcellini, Rosaria Russo, Michele Romano, Iolanda Enea, Min Ae Lee, Bruno Trimarco
Journal: Circulation Research (1995)

The transgenic (TG) rat (mREN2)27 is characterized by overexpression of the additional mouse Ren-2d gene in the adrenal cortex with marked suppression of renal renin. We have previously shown that in salt-depleted TG rats enhanced activation of mineralocorticoid biosynthesis is associated with selective stimulation of adrenal renin. To investigate whether the local renin-angiotensin system regulates aldosterone biosynthesis in the adrenal cortex of TG rats, we studied the effects of the AT1-angiotensin subtype receptor antagonist DuP 753 on aldosterone production in 5-week-old TG rats during salt restriction. All the rats (n = 56) were shifted from regular chow to a diet containing only 0.04% NaCl for 1 week. The AT1-receptor antagonist DuP 753 (10 mg/kg per day in drinking water) was administered to 27 of these rats during low-salt diet. Subgroups of rats were killed at 0,4, and 7 days. Low-salt diet increased both adrenal renin activity (from 31 +/- 3 to 77 +/- 4 and 85 +/- 2 ng angiotensin I.h-1.mg protein-1 at 4 and 7 days, respectively; P < .001) and mRNA (by 68.4 +/- 10% and 80 +/- 17% from baseline, P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)
Differences in endothelial function between patients with ischemic and dilated heart failure
Authors: Dimitris Tousoulis, Charalambos Antoniades, Costas Tentolouris, Stella Brill, Kyriakoula Marinou, Marleta Charakida, Christos Pitsavos, Christodoulos Stefanadis, Pavlos Toutouzas
Journal: Journal of the American College of Cardiology (2002)
Visualization of Thrombi in Pulmonary Arteries With Radiolabeled, Enzymatically Inactivated Tissue-Type Plasminogen Activator
Authors: Van H. De Bruyn, Steven R. Bergmann, Bruce A. Keyt, Burton E. Sobel
Journal: Circulation (1995)

Background Despite the high frequency of pulmonary thromboembolism and its significant morbidity and mortality, diagnosis remains suboptimal. We have been developing a method for prompt detection with the use of radiolabeled, inactivated tissue-type plasminogen activator (TPA) and performed the present study to determine whether its use permits rapid scintigraphic visualization of pulmonary thrombi in vivo. Methods and Results The thrombolytic, but not fibrin-binding, property of TPA was inactivated with a tripeptide chloromethyl ketone (YPACK) that had already been iodinated with 123 I to radiolabel the TPA. Pulmonary arterial thrombosis was induced in nine dogs with the use of guide wires modified to provide thrombogenic tips. 123 I-YPACK-TPA (1.1 to 7.8 mCi, 0.5 to 7.8 mg) was infused for 5 minutes into either the systemic or the pulmonary circulation. Clearance of radioactivity from the blood was rapid and indistinguishable from that of unlabeled, thrombolytically active TPA, with only 6.7±1.0% (mean±SEM) of peak radioactivity remaining after 60 minutes and minimal release of labeled fragments from the liver during this interval. Thrombi were visualized with single photon emission computed tomography and/or planar imaging 40 to 120 minutes after infusion of tracer in all seven animals given at least 3.7 mCi of 123 I-YPACK-TPA. Ratios of radioactivity in thrombus (wet mass, 610±64 mg) to blood were high (14±3:1). Conclusions The use of radiolabeled TPA in which thrombolytic activity is inactivated permits prompt scintigraphic detection of thrombi in pulmonary arteries in vivo.
From the Alcohol, Drug Abuse, and Mental Health Administration
Authors: E. Johnson
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of chrysotherapy on circulating lymphocyte numbers and subsets.
Authors: M D Smith, A Smith, M Fehr, M J Ahern, P J Roberts-Thomson
Journal: Annals of the Rheumatic Diseases (1988)

In a prospective 24 week study of 25 patients with rheumatoid arthritis (RA) weekly intramuscular (IM) sodium aurothiomalate resulted in a small but significant reduction in the circulating lymphocyte count. Analysis of absolute levels of pan T cells, T4 helper cells, T8 suppressor cells, T4/8 ratio, B cells, and major histocompatibility complex (MHC) class II positive cells showed reductions in these subsets, though these changes did not reach significance. At entry there was no association between circulating lymphocyte counts and subsets and clinical and laboratory indices which reflected disease activity, and during the study gold responders could not be differentiated from non-responders with regard to changes in lymphocyte counts and subsets. Thus this study suggests that weekly IM gold leads to a modest reduction in circulating lymphocyte numbers which involves most subsets. This effect appears to be independent of the clinical efficacy of this drug.
Infusion of liver tumours.
Authors: N. D. Harvey
Journal: BMJ (1968)

MEDIBJOURNgiven a bottle of antibiotic and is under the impression that once the total contents have been taken no further treatment is necessary.Repeated attacks of otitis media may be due to sterile pus remaining within the middle ear, but it is essential to look for con- tributory lesions in the rest of the upper respiratory tract.The adenoids and sinuses are sources of infection which demand investigation and treatment.The " glue ear " is a well-recognized cause of deafness in children,'but is overlooked because the drums appear normal.Abnormal physical signs such as a blue or yellow drum may be seen, but in a small child with a narrow canal it may be difficult to be certain of the appear- ance of the drum.
Oral rapamycin attenuates progression of atherosclerotic plaque in ApoE knockout mice
Authors: Rajbabu Pakala, Mary Susan Burnett, Cindy P. Gulick, Jana Fournadjiev, Laurent Leborgne, Edouard F. Cheneau, David Hellinga, Stephen E. Epstein, Ron Waksman
Journal: Journal of the American College of Cardiology (2003)
275 A COMPARISON OF PRIMARY SURGICAL RESECTION TO LIVER TRANSPLANTATION (LT) AMONG TRANSPLANT-ELIGIBLE HEPATOCELLULAR CARCINOMA (HCC) PATIENTS USING AN INTENTION-TO-TREAT MODEL
Authors: R.J. Wong, J. Wantuck, A. Valenzuela, A. Ahmed, C. Bonham, A. Gallo, M. Melcher, G. Lutchman, W. Concepcion, C. Esquivel, G. Garcia, T. Daugherty, M.H. Nguyen
Journal: Journal of Hepatology (2013)
Venus on the Right
Authors: William G. Porter
Journal: Annals of Internal Medicine (1998)

On Being a Patient15 March 1998Venus on the RightWilliam G. Porter, MDWilliam G. Porter, MDCarolinas Medical Center; Charlotte, NC 28232Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-6-199803150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail One of the joys of our summer vacations on Nantucket is seeing our friend Eileen, now in her early 70s, who lives year-round on the island. For years, Eileen taught biology in Providence at the Quaker girls' school my wife attended. But in all her years on the mainland, her heart never left her native Nantucket. At the end of every school year, she hurried home to enjoy summer on the island. When she retired, she went back for good to her cozy house at the edge of a meadow and settled in with her dog and cat. She took ... Author, Article, and Disclosure InformationAffiliations: Carolinas Medical Center; Charlotte, NC 28232Corresponding Author: William G. Porter, MD, Department of Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1998Volume 128, Issue 6Page: 500-501KeywordsAnginaExerciseGratitudeHealth care qualityHeartMyocardial infarctionSafetyStent implantationStormsThrombosis Issue Published: 15 March 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome
Authors: Christian Windpassinger, Michaela Auer-Grumbach, Joy Irobi, Heema Patel, Erwin Petek, Gerd Hörl, Roland Malli, Johanna A Reed, Ines Dierick, Nathalie Verpoorten, Thomas T Warner, Christos Proukakis, Peter Van den Bergh, Christine Verellen, Lionel Van Maldergem, Luciano Merlini, Peter De Jonghe, Vincent Timmerman, Andrew H Crosby, Klaus Wagner
Journal: Nature Genetics (2004)
Efficacité de la coagulation au plasma-argon des ectasies vasculaires antrales: comparaison chez des malades cirrhotiques et des malades non-cirrhotiques
Authors: S Lecleire, E Ben Soussan, M Antonietti, E Lerebours, P Ducrotté
Journal: Endoscopy (2007)

Les ectasies vasculaires antrales (EVA) représentent une cause rare d'hémorragie digestive ou d'anémie ferriprive. Elles sont plus fréquentes chez les malades atteints de cirrhose, mais peuvent aussi survenir chez des malades atteints de pathologies chroniques rénales, cardiaques ou auto-immunes. Le but de cette étude était de comparer les caractéristiques cliniques, endoscopiques et la réponse au traitement par coagulation au plasma-argon (CPA) des malades présentant des EVA symptomatiques, selon qu'ils soient atteints de cirrhose ou non.
Low dose oxybutynin for the unstable bladder.
Authors: J. Malone-Lee, D. Lubel, G. Szonyi
Journal: BMJ (1992)

Numbers of infants categorised according to quintiles ofratio ofplacental weight to birth weight and by gestational age and birth weight (figures in parentheses are column percentages) NoWeeks of gestation Birth weight (g) of Placental weight:birth weight infants
Disseminated Cryptococcosis: Detection by F-18 FDG PET
Authors: N Seshadri, B Kaur, K Balan
Journal: Clinical Nuclear Medicine (2007)

Disseminated cryptococcosis occurs in immunocompromised patients and can affect the skin, prostate, and bones apart from the lungs. Cutaneous manifestations are seen in 10%–15% of cases. Other less common forms of cryptococcosis include myocarditis, hepatitis, chorioretinitis, peritonitis, and renal abscesses. There have been reports of detection of pulmonary cryptococcosis on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET), which may sometimes lead to diagnostic pitfalls. We report here an unusual case of disseminated cryptococcosis in an immunocompromised patient, which was demonstrated on FDG-PET. The initial diagnosis of cryptococcosis had been made by blood culture and skin biopsy. The chest x-ray was normal but CT showed a solitary pulmonary nodule on the left side. There was, however, uncertainty as to whether the latter was benign or malignant. The whole-body PET images showed multiple sites of abnormal FDG uptake in the skin, lymph nodes, spleen, and lungs, the findings of which were confirmed as cryptococcosis by postmortem examination.
Patterns of Prevalent Major Chronic Disease Among Older Adults in the United States
Authors: Carlos O. Weiss, Cynthia M. Boyd, Qilu Yu, Jennifer L. Wolff, Bruce Leff
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE USE OF BACILLUS ACIDOPHILUS MILK IN A TUBERCULOSIS SANATORIUM
Authors: WILLIAM H. MORRISS
Journal: JAMA (1923)

One of the principal difficulties that arise in the practice of every sanatorium physician is the proper care of the manifold gastro-intestinal complications that occur so frequently in any group of tuberculous patients. It is, indeed, rare that a patient with pulmonary tuberculosis does not develop, at some time in his sanatorium life, a complaint attributable to the gastro-intestinal system. Most frequently this is merely a transitory disturbance, one liable to arise in any group of chronic patients, whatever the nature of their disease when living under conditions of a sanatorium regimen. Aside from this group of minor gastric ailments, there are many patients that develop symptoms of definite gastric motor and secretory disturbances, as well as intestinal symptoms of diarrhea, severe constipation, and generalized abdominal pain. A small proportion of this group can be attributed to tuberculous disease of the intestinal tract, which certainly is far more common than
NEPHRECTOMY, SUBSEQUENT NEPHROTOMY AND FINALLY SUPRAPUBIC CYSTOTOMY.
Authors: E. D. FERGUSON
Journal: JAMA (1902)

The serious or fatal result that often arises from moderate or even slight operative interference with the genito-urinary apparatus, as in anuria from a nephrotomy, or serious "urinary fever" from the passage of a urethral instrument, has its counterpart in the occasional tolerance of extensive, repeated and prolonged operative procedures on these organs. The past twenty-one years, during which a portion of the care of the kidneys has passed from the field of the physician to that of the surgeon, have been marked by notable examples of the change in our lines of demarcation for work, and even now the relative fields are changing in the claim that Bright's disease, at least in some varieties, is to come under the surgeons care. In the somewhat over fifteen years, during which I have had occasion to resort to surgical measures on the kidneys, I have had opportunity to realize that a
Headache Due to Impacted Molar
Authors: Joseph Lubart
Journal: JAMA (1974)

A white woman, aged 32, described left-sided headaches of four years' duration. They were not affected by time of day or changes in weather and were relieved only slightly by aspirin. Since December 1972, the headaches became more severe and awakened her at night. The patient was not able to follow her occupation since February 1973. She underwent a Caldwell-Luc operation on the left 13 years earlier, and had the first and second left upper molars removed because of caries five years ago. On physical examination, there was slight tenderness over the left malar region. The nasal septum was significantly deviated to the left with obstruction of the upper nasal passages. There was an adhesion between the nasal septum and the left inferior turbinate. There was a perforation in the posterior part of the nasal septum due apparently to a previous septectomy, probably at the time of the Caldwell-Luc operation.
Reviews and Notes: Doctors and Their Feelings: A Pharmacology of Medical Caring
Authors: Eric J. Cassell
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 September 1993Reviews and Notes: Doctors and Their Feelings: A Pharmacology of Medical CaringEric J. Cassell, MDEric J. Cassell, MDCornell University Medical Center, New York, New York 10021.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-5-199309010-00040 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Doctors and Their Feelings: A Pharmacology of Medical CaringBenjamin Maoz, Stanley Rabinowitz, Michael Herz, and Hava Elkan Katz. 168 pages. Westport, Connecticut: Praeger; 1992. $47.95.In the 1950s, the psychiatrist Michael Balint recognized that the tool in therapeutic endeavors is the doctor. If the physician is in poor emotional or physical condition, the tool is as blunted as it would be by ignorance. Balint organized what came to be called Balint groups, where physicians could discuss among themselves the emotional problems and burdens caused by the care of the sick. The idea was not as widely accepted as the need seemed ... Author, Article, and Disclosure InformationAffiliations: Cornell University Medical Center, New York, New York 10021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1993Volume 119, Issue 5Page: 443KeywordsAggressionEmotionsFearGratitudePatientsPharmacology ePublished: 15 August 2000 Issue Published: 1 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
STUDIES ON NON-PRECIPITATING ANTIBODY
Authors: Ludwig A. Sternberger
Journal: The Journal of Experimental Medicine (1956)

Reinjection of antigen into immunized rabbits usually results in an immediate increase of circulating antibody-antigen complex. This immediate formation of complex seems to depend upon the presence of non-precipitating antibody before reinjection. The complex disappears by the 2nd day after reinjection and reappears between the 4th to 7th day. This is earlier than its first appearance after a primary injection and may indicate an anamnestic response of the non-precipitating antibody responsible for the formation of circulating antibody-antigen complex.
Smoking during pregnancy and congenital limb deficiency
Authors: P Lee
Journal: BMJ (1994)

documented in the narrative of the notes they may not be apparent on a rapid skim through the notes and an entry about resuscitation status that is not the most up to date may be found.A sheet at the back of the notes giving sequential decisions on resuscitation status perhaps solves this problem, but if the sheet is not updated the information can be misleading.I would be interested to know whether any other departments have managed to find a system that really works in a busy department (at least 1100 admissions a year per consultant).I also wonder whether, if communication between doctors and nurses is accurate (and this can easily be audited), the requirement for the consultant to generate updates in the notes each day results in unnecessary bureaucracy.
SOME PATHOLOGIC CONDITIONS OF THE OVARIES THAT CAUSE GREAT PAIN.
Authors: GEORGE HALLEY
Journal: JAMA (1899)

No physician who has been engaged long in the practice of medicine has not had complaints coming to him from his female patients, of excessive pains in the lower portion of the abdomen. The pain is not always confined to the pelvic portion of the abdominal cavity; but often extends both above and below it. The pain radiating upward from the pelvis, follows a line about two inches inside the crest of the ilium, radiating upward and backward, often losing itself beneath the floating ribs. Downward, it is found most often in the front of the thigh. Occasionally it is found on the outside of the thigh, and rarely in the back part of it. Sometimes it is confined entirely to the lower portion of the iliac fossa and upper two inches of the thigh. The pain is usually of a dull. aching, persistent character; increased markedly by physical exertion
Involvement of Family Physicians in the Care of Cancer Patients Seen in the Palliative Rapid Response Radiotherapy Program
Authors: Elizabeth A. Barnes, Grace Fan, Kristin Harris, Meagan Doyle, Lawrence S. Librach, Edward Chow, Lisa Barbera, May Tsao, Kelvin Lam, Cyril Danjoux
Journal: Journal of Clinical Oncology (2007)

It is important for cancer patients to maintain continuity of care with their family physician (FP) while being followed at the cancer center. The primary objective of this study was to determine the perception of patients seen in the palliative Rapid Response Radiotherapy Program (RRRP) on FP involvement in their cancer care. Secondary objectives were to identify factors predicting for perceived FP involvement in patient cancer care.Consecutive patients were approached for study enrollment at the time of RRRP visit and asked to complete a 15-item survey.Three hundred sixty-five patients were accrued over 15 months. Ninety-eight percent had an FP, and 43% felt their FP was involved in their cancer care. Eighty percent of patients were satisfied with the overall medical care provided by their FP, and 71% had been with their FP for > or = 5 years. The most common reason patients gave for perceiving limited FP involvement was the medical oncologist looking after all of their cancer needs. Multivariate analysis found that satisfaction with overall medical care provided by the FP, shorter time since last FP visit, seeing the FP since cancer diagnosis, and FP providing on-call service for after-hour emergencies all significantly predicted for patients perceiving FP involvement in their cancer care.Less than half of patients surveyed perceived their FP as involved in their cancer care. Encouraging continuity of care between patients and FPs may allow for easier transition of care back to the FP once palliative treatment at the cancer center has finished and help facilitate end-of-life planning.
Partial Characterization of Glycan Ligands in Mouse Lung for The Eosinophil-Selective Surface Protein Siglec-F
Authors: H.J. Na, J.P. Guo, M.E. Brummet, A.C. Myers, D.A. Kuperman, E. Rowland, R.L. Schnaar, T. Zheng, Z. Zhu, B.S. Bochner
Journal: Journal of Allergy and Clinical Immunology (2010)