tbuckley/cabot-search huggingface dataset:
ACUTE SCARLATINIFORM DERMATITIS FOLLOWING INJECTION OF TOXOID-ANTITOXIN
Authors: G. Chesney
Journal: BMJ (1933)

indurated and tender.As I had previously had injections of ACUTE SCARLATINIFORM DERMATITIS T.A.M., and was also a pseudo and negative reactor, I injected FOLLOWING INJECTION OF-a similar dose of the dilute T.A.M. intradermally in my forearm as a control, and in twenty-four hours there was a faint TOXOID-ANTITOXIN flush, without induration or tenderness, which faded by the following day.The result of this test added further conl-BY firmation that the patient was very sensitive to even small GEORGE CHESN:E:Y, M.B
Stage-dependent reduction in T colony formation in Hodgkin's disease. Coincidence with monocyte synthesis of prostaglandins.
Authors: R S Bockman
Journal: Journal of Clinical Investigation (1980)

Prostaglandin synthesis and T lymphocyte colony formation have been examined in previously untreated patients with Hodgkin's disease. Mononuclear cells have been isolated from peripheral blood and spleens of these patients. Significant augmentation in prostaglandin E levels were noted in the mononuclear cell cutures from Hodgkin's disease patients compared with controls (1.64 +/- 0.29 vs. 0.39 +/- 0.09 ng/10(6) cells, P < 0.005). Measured prostaglandin E levels increased with advancing stage of disease. Virtually all of the prostaglandins were synthesized by the adherent monocyte cell population. Prostaglandin E was the major product. Clonal expansion of a T lymphocyte precursor cell, which gives rise to colonies > 50 cells, was determined by a layered soft agar method. T colony formation was significantly reduced in patients with stage II, III, and IV disease. There were progressively reduced colony numbers seen with advancing stage of disease (609 +/- 209, 416 +/- 158, 207 +/- 58 compared with normals 2,274 +/- 360 colonies/10(6) cells plated; P < 0.005). The addition of inhibitors of endogenous prostaglandin synthesis resulted in significant augmentation of T colony number. However, a consistent relative decrease in T colony number was seen even when endogenous prostaglandin E synthesis was blocked. It would appear that both the prostaglandin-dependent and independent T colony precursor cells are lost with progressive stage of disease. A causative role of augmented prostaglandin synthesis in this stage-dependent reduction of T colony formation could not be established.
LIMITATIONS OF SYMPATHECTOMY IN TREATMENT OF DIASTOLIC HYPERTENSION
Authors: Geza de Takats
Journal: JAMA (1952)

Essential hypertension is a progressive disease that is usually discovered by the general practitioner or at preemployment, insurance, or preinduction examinations. Obviously the majority of patients with hypertension do not need operation, but early intensive study is imperative, since a decision to operate may well depend on the discovery of progressive vascular disease in the cerebral, retinal, cardiac, renal, and peripheral vascular areas.  The purpose of this paper is to present some tentative conclusions about when to operate, what type of operation to do, and how to interpret results in patients who have diastolic hypertension. Excluded from this discussion are patients with well-defined causes of hypertension, such as coarctation of the aorta, unilateral renal disease, pheochromocytoma, corticoadrenal tumors, and the full-blown Cushing's syndrome. This leaves a large number of patients affected by a hypertensive cardiorenal disease, for which a variety of etiologic factors, classifications, and methods of management have been
Cardiac Improvement During Mechanical Circulatory Support
Authors: Simon Maybaum, Donna Mancini, Steve Xydas, Randall C. Starling, Keith Aaronson, Francis D. Pagani, Leslie W. Miller, Kenneth Margulies, Susan McRee, O.H. Frazier, Guillermo Torre-Amione
Journal: Circulation (2007)

Background— Myocardial recovery after left ventricular assist device (LVAD) support has been reported. The LVAD Working Group Recovery Study was a prospective multicenter trial to assess the incidence of myocardial recovery in patients bridged to cardiac transplantation. Methods and Results— After LVAD implantation, patients were evaluated with the use of rest echocardiograms with partial LVAD support and cardiopulmonary exercise testing. Dobutamine echocardiography with hemodynamic measurements was performed in those patients with left ventricular ejection fraction &gt;40% during resting studies. Histological analysis was performed on myocardial samples taken at LVAD implantation and explantation. Sixty-seven LVAD patients with heart failure participated in the study. After 30 days, significant improvement occurred in left ventricular ejection fraction (17±7% versus 34±12%; P &lt;0.001) and reductions in left ventricular end-diastolic diameter (7.1±1.2 versus 5.1±1.1 cm; P &lt;0.001) and left ventricular mass (320±113 versus 194±79 g; P &lt;0.001) compared with before LVAD. Thirty-four percent of patients had left ventricular ejection fraction &gt;40% with partial device support. Left ventricular ejection fraction decreased over time to pre-LVAD measurement by 120 days. Peak V̇ o 2 improved with mechanical support (13.7±4.2 versus 18.9±5.5 mL/kg per minute, 30 versus 120 days; P &lt;0.001). Tissue analysis revealed significant reductions in myocyte size, collagen content, and cardiac tumor necrosis factor-α. Six subjects (9%) underwent LVAD explantation for recovery. Conclusions— Cardiac function improves significantly after device implantation. Although cellular recovery and improvement in ventricular function are observed, the degree of clinical recovery is insufficient for device explantation in most patients with chronic heart failure.
Bile leak risk after laparoscopic cholecystectomy
Authors: V R Kale
Journal: BMJ (1994)

EDITOR, - I was interested in the account of laparoscopic cholecystectomy by R C G Russell.1 Complications of retained intraperitoneal calculi and biliary leak seem to be more common after laparoscopic than open cholecystectomy.2,3

A 40 year old woman who suffered from biliary colic in July 1992 was found to have a gall bladder full of stones. She was admitted for laparoscopic cholecystectomy in September 1993. At operation …
THE EFFECTS OF ADMINISTRATION OF ASCORBIC ACID IN EXPERIMENTALLY INDUCED MILIARIA AND HYPOHIDROSIS IN VOLUNTEERS
Authors: T. C. HINDSON, D. E. WOESLEY
Journal: British Journal of Dermatology (1969)

Journal Article THE EFFECTS OF ADMINISTRATION OF ASCORBIC ACID IN EXPERIMENTALLY INDUCED MILIARIA AND HYPOHIDROSIS IN VOLUNTEERS Get access T. C. HINDSON, T. C. HINDSON British Military Hospital and Army Medical Research Unit Singapore Search for other works by this author on: Oxford Academic Google Scholar D. E. WOESLEY D. E. WOESLEY British Military Hospital and Army Medical Research Unit Singapore Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 3, 1 March 1969, Pages 226–227, https://doi.org/10.1111/j.1365-2133.1969.tb16013.x Published: 01 March 1969 Article history Accepted: 30 August 1968 Published: 01 March 1969
Abstract 15075: QRS-T Morphology Measured from Exercise Electrocardiogram as a Predictor of Cardiac Mortality
Authors: Tuomas Kentta, Mari Karsikas, M Juhani Junttila, Juha S Perkiomaki, Tapio Seppanen, Tuomo Nieminen, Terho Lehtimaki, Kjell Nikus, Rami Lehtinen, Jari Viik, Mika Kahonen, Heikki Huikuri
Journal: Circulation (2010)
RELIABILITY OF RETROSPECTIVE PERFORMANCE DATA IN ELITE 400-M SWIMMING AND 1500-M RUNNING
Authors: GJ Mytton, DT Archer, KG Thompson, A St Clair Gibson
Journal: British Journal of Sports Medicine (2013)

It is beneficial for coaches and athletes to know the most effective pacing profiles that have occurred during elite races and to establish how reproducible these profiles are in order to assist tactical preparation for competition (Tucker et al . IJSPP 2006;1:233–245). This study aimed to establish the repeatability of lap data of international standard competitors in 400-m freestyle swimming and 1500-m track athletics, events of similar duration. Data were collected from five Olympic, World and European international competitions between 2005 and 2011 in 400-m swimming and 1500-m running events. Swimming lap times were freely available in the public domain from the Omega Timing results service (www.omegatiming.com). Running lap times were measured using a validated frame by frame playback method (Mytton et al . IJSPP 2013, e-pub). Eleven swimmers and twelve runners with repeat final appearances were analysed with a mean time between finals of 20.5±13.3 months. Trial one to trial two data were compared using Hopkins’ reliability spreadsheet (Hopkins, Sport Sci 2011) and the typical error (TE) and coefficient of variation (CV) reported. The TE and CV values tended to increase in swimming but significantly decreased in running as laps progressed. CV values were greater in running than swimming in laps 1 (p=0.001), 2 (p=0.01) and 4 (p=0.01) but not different in lap 3 or for total time (p&gt;0.05). The findings of this study suggest that in elite competitors, within-subjects reliability for 400-m swimming is greater than for 1500-m running times. The differences in reliability between exercise modalities might be due to a number of factors such as a greater degree of tactical racing in the early laps in track athletics when athletes compete for position, the manner of the start being different to swimming (i.e. dive start in swimming), and differences in mechanical efficiency, kinetic energy production and loss between the two sports (de Koning et al . PIoS One 6:e15863).
Abstract 4229: Dichamanetin, a C-benzylated flavonoid from Piper sarmentosum inhibits cell growth and induces G1 cell cycle arrest in cancer cells through mitochondrial-mediated apoptosis
Authors: Susan Matthew, Li Pan, Qi Shen, A. Douglas Kinghorn, Steven M. Swanson, Esperanza J. Carcache de Blanco
Journal: Cancer Research (2011)

Abstract Dichamanetin (C29H24O6) is a rare C-benzylated flavanoid isolated as a major metabolite from Piper sarmentosum Roxb. (Piperaceae). Dichamanetin significantly decreased the cell viability of various types of cancer cells in a dose- and time-dependent manner, characterized by G1 arrest of the cell cycle. In the present study, we investigated the molecular mechanism whereby dichamanetin exerts its cytotoxic effect on human cancer cells in vitro. We examined the involvement of ROS-signaling components (ROS levels, NF-kB transcription factor, mitochondrial membrane potential, DNA damage, and proteasome inhibition) and demonstrated that the antiproliferative effect of cancer cells is partially mediated by induction of oxidative stress. Dichamanetin treatment did not significantly inhibited proteasome, but inhibited moderately PARP-1 enzyme activity. Additionally, FACS analysis with JC-1 fluorescent dye established significant deviation of mitochondrial membrane potential by dichamanetin in treated cells. The present data therefore supports dichamanetin as an active anti-proliferative metabolite that acts in part through mitochondrial-mediated apoptosis. Acknowledgment This research was supported by Program Project Grant P01-CA125066 funded by the National Cancer Institute, NIH. We also wish to acknowledge the plant taxonomists who collected the plant material used in this investigation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4229. doi:10.1158/1538-7445.AM2011-4229
Dual antigenic recognition by cloned human gamma delta T cells.
Authors: J Holoshitz, L M Vila, B J Keroack, D R McKinley, N K Bayne
Journal: Journal of Clinical Investigation (1992)

The function of gamma delta T cells is still elusive. The nature of the antigens that they recognize and the mode of presentation of these antigens are largely unknown. The majority of human peripheral gamma delta T cells bear a V gamma 9/V delta 2 T cell receptor, and display nonclonal reactivity to mycobacteria, without restriction by MHC. It is unknown whether these cells have clonal antigenic specificity as well. Here we describe rheumatoid arthritis-derived V gamma 9/V delta 2 T cell clones, displaying dual antigenic recognition: a nonclonal, MHC-unrestricted recognition of mycobacteria, and a clonal recognition of a short tetanus toxin peptide presented by HLA-DRw53, a nonpolymorphic class II MHC molecule associated with susceptibility to rheumatoid arthritis. This is the first evidence that V gamma 9/V delta 2 T cells can recognize nominal antigenic peptides presented by class II MHC molecules. These results suggest that much like alpha beta T cells, V gamma 9/V delta 2 cells may contribute to the immune response against foreign antigens in an antigen-specific and MHC-restricted manner. The reactivity of these gamma delta T cells to mycobacteria may represent a superantigen-like phenomenon.
The Efficacy and Safety of Dermagraft in Improving the Healing of Chronic Diabetic Foot Ulcers
Authors: William A. Marston, Jason Hanft, Paul Norwood, Richard Pollak
Journal: Diabetes Care (2003)

OBJECTIVE—To determine if a human fibroblast–derived dermal substitute could promote the healing of diabetic foot ulcers. RESEARCH DESIGN AND METHODS—A randomized, controlled, multicenter study was undertaken at 35 centers throughout the U.S. and enrolled 314 patients to evaluate complete wound closure by 12 weeks. Patients were randomized to either the Dermagraft treatment group or control (conventional therapy). Except for the application of Dermagraft, treatment of study ulcers was identical for patients in both groups. All patients received pressure-reducing footwear and were allowed to be ambulatory during the study. RESULTS—The results demonstrated that patients with chronic diabetic foot ulcers of &amp;gt;6 weeks duration experienced a significant clinical benefit when treated with Dermagraft versus patients treated with conventional therapy alone. With regard to complete wound closure by week 12, 30.0% (39 of 130) of Dermagraft patients healed compared with 18.3% (21 of 115) of control patients (P = 0.023). The overall incidence of adverse events was similar for both the Dermagraft and control groups, but the Dermagraft group experienced significantly fewer ulcer-related adverse events. CONCLUSIONS—The data from this study show that Dermagraft is a safe and effective treatment for chronic diabetic foot ulcers.
Reply to: "Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development" and "Replication studies in various ethnic populations do not support the association of the HIF-2α SNP rs17039192 with knee osteoarthritis"
Authors: Taku Saito, Akihiko Mabuchi, Toru Akune, Ung-il Chung, Katsushi Tokunaga, Hiroshi Kawaguchi
Journal: Nature Medicine (2011)
Thyroid Hormones in Pregnancy in Relation to Environmental Exposure to Organochlorine Compounds and Mercury
Authors: Larissa Takser, Donna Mergler, Mary Baldwin, Sylvie de Grosbois, Audrey Smargiassi, Julie Lafond
Journal: Environmental Health Perspectives (2005)

Polychlorinated biphenyls (PCBs), chlorinated pesticides, and mercury are global environmental contaminants that can disrupt the endocrine system in animals and humans. However, there is little evidence that they can interfere with endocrine status in pregnant women and neonates at low levels of exposure. The aim of this study was to examine thyroid hormone levels during pregnancy and in cord blood in relation to blood concentrations of organochlorine compounds (OCs) and Hg in healthy women recruited during pregnancy. We found a significant negative correlation between maternal total triiodothyronine levels and three non-coplanar congeners (PCB-138, PCB-153, and PCB-180), three pesticides (p,p′-DDE, cis-nanochlor, and hexachlorobenzene), and inorganic Hg independently, without any other changes in thyroid status. No significant relationships were observed between OCs and cord serum thyroid hormones. Cord serum free thyroxin was negatively correlated with inorganic Hg. These results suggest that at even low levels of exposure, persistent environmental contaminants can interfere with thyroid status during pregnancy.
Morphologic Findings in Human Cardiac Allografts
Authors: JOHN D. MILAM, FREDRICK H. SHIPKEY, CARL J. LIND, JAMES J. NORA, ROBERT D. LEACHMAN, DONALD G. ROCHELLE, ROBERT D. BLOODWELL, GRADY L. HALLMAN, DENTON A. COOLEY
Journal: Circulation (1970)

Morphologic findings in human cardiac allografts from 13 patients are presented. In the acutely rejected cardiac allograft there was a cellular infiltrate consisting of large lymphocytes and varying numbers of polymorphonuclear leukocytes, eosinophils, and histiocytes in the myocardium and arterial intima. The coronary arteries frequently exhibited degeneration, acidophilia, and vacuolation of the tunica media. In the cases with chronic cardiac allograft rejection there was obliterative fibrous thickening of the arterial intima with medial necrosis. Focal areas of myocardial necrosis and fibrosis were present along with a myocardial infiltrate of mononuclear cells. In most patients who died of causes other than rejection, there was evidence of an immunologic response. Rejection has not been regarded as an "all or none" phenomenon. There was indication in this series that survival was related to histocompatibility.
Amenorrhea Associated With Carotenemia
Authors: Micheline M. Mathews-Roth
Journal: JAMA (1983)

<h3>To the Editor.—</h3> I read the article entitled "Amenorrhea Associated With Carotenemia" by Kemmann et al (1983;249:926). I am concerned with the authors' suggestion that carotenemia may perhaps be associated with the<i>development</i>of amenorrhea. It may be rather tenuous to implicate beta carotene as the cause of an effect when the source of this compound is a diet rich in carotenoid-containing vegetables. It must be remembered that beta carotene is only a minor component of vegetables and that some of the other components may have toxic effects when ingested in large quantities. An example of this was a report of leukopenia occurring after the ingestion of large amounts of carrots; the leukopenia reversed itself when carrot intake was decreased and did not recur when pure (crystalline) beta carotene was given.<sup>1,2</sup>This finding indeed suggests that some component of carrots other than the beta carotene was causing the leukopenia.
Short course zidovudine cuts vertical transmission of HIV
Authors: Z. Kmietowicz
Journal: BMJ (1999)

A short course of the anti-HIV drug zidovudine can halve the rate of mother to child transmission in women who do not breastfeed and can reduce transmission among those who do by one third, according to the latest research.

The regimen could benefit thousands of babies in developing countries, where 90%of infant infections occur, and where previously there has been no strategy to reduce the risk of transmission. Every year 600000 infants are born with HIV. Without intervention 15–30%of babies are infected during labour and a further 15–30% through breastfeeding.

The short course of zidovudine treatment is a simplified version of that developed in 1994 by the Pediatric AIDS Clinical Trials Group (known as the 076 protocol), …
Oxacillin and the Liver
Authors: AILEEN DENNY
Journal: Annals of Internal Medicine (1979)

Letters1 February 1979Oxacillin and the LiverAILEEN DENNY, M.D., JAMES ADAMS, M.D., T. C. MILLER, M.D.AILEEN DENNY, M.D.Search for more papers by this author, JAMES ADAMS, M.D.Search for more papers by this author, T. C. MILLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-277_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent article (1) hepatitis from intravenous oxacillin therapy was reported in eight patients. When we received that issue of theAnnalswe were treating a 62-year-old woman forStaphylococcus aureusendocarditis with intravenous oxacillin and gentamicin. Symptoms of nausea, malaise, and anorexia with hepatic enlargement and tenderness began after 4 days of oxacillin (total dose of 60 g). After 8 days of oxacillin, the drug was discontinued. The patient was known to have hepatic congestion secondary to tricuspid insufficiency with baseline serum glutamic-oxalacetic transaminase (SGOT) levels of 60 to 100 mU/ml (normal, 5 to 40...Reference1. ONORATOAXELROD IJ: Hepatitis from intravenous high-dose oxacillin therapy. Findings in an adult inpatient population. Ann Intern Med 89:497-500, 1978. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Minnesota Unit for Teaching and Research in Internal Medicine Northwestern Hospital Minneapolis, MN 55407 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1979Volume 90, Issue 2Page: 277-277KeywordsAminotransferasesDrugsEndocarditisHepatitis ALiverNauseaSerum glutamic oxaloacetic transaminaseStaphylococcus aureus Issue Published: 1 February 1979 PDF DownloadLoading ...
Germany puts universal health e-card on hold
Authors: A. Tuffs
Journal: BMJ (2010)

Germany’s health minister, Philipp Rosler, has decided to put on hold the introduction of the planned electronic health card system, whereby every citizen was meant to hold an electronic card carrying their health data, medical history, prescriptions, and insurance status.

The project, originally to have been launched in January 2006, has so far cost the country’s health insurance companies and its government a total of €1.7bn (£1.5bn; $2.5bn).

The new German government, a coalition of the Christian Democrats and the liberal Free Democratic Party, has decided to review the plans, which were the work of the former …
Arthritis in Roman Britain.
Authors: A K Thould, B T Thould
Journal: BMJ (1983)

The pattern of arthritis in Roman Britain was investigated by examining the skeletons of 416 adults from the Roman cemetery at Poundbury Camp near Dorchester, Dorset. The mean height of the people was not much less than that of the current British population, and the prevalence of right handedness was similar to our own. There was a high prevalence of osteoarthritis for such a relatively young community, with particularly severe changes in the vertebral column. The pattern of joints affected by osteoarthritis was different from that seen now, but the prevalence of vertebral ankylosing hyperostosis was much the same. Rheumatoid arthritis was seen as often as the expected rat would indicate, given that the population died young, but it was rare. Other forms of arthritis, including gout and ankylosing spondylitis, were not seen.
Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: Comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores
Authors: Laurent Castéra, Brigitte Le Bail, Françoise Roudot-Thoraval, Pierre-Henri Bernard, Juliette Foucher, Wassil Merrouche, Patrice Couzigou, Victor de Lédinghen
Journal: Journal of Hepatology (2008)
Capsule Endoscopy, Transit Times, and Whipple’s Disease
Authors: G. Gay, J.-F. Roche, M. Delvaux
Journal: Endoscopy (2005)

We read with interest the recent case report by Fritscher-Ravens et al. [1], in which they described a patient with refractory Whipple’s disease, explored by capsule endoscopy. The authors made two interesting observations: firstly, that the intestinal lesions of Whipple’s disease appear to involve the whole of the small intestine; and, secondly, that malabsorption could at least partly result from accelerated intestinal transit in patients with Whipple’s disease, as they measured a transit time of the capsule through the small bowel of 2 hours 43 minutes (163 minutes).