Treatment of Acute Leukemia
Authors: EDWARD S. HENDERSON
Journal: Annals of Internal Medicine (1968)

Editorials1 September 1968Treatment of Acute LeukemiaEDWARD S. HENDERSON, M.D.EDWARD S. HENDERSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-3-628 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI would rather learn from one bird how to sing than teach ten thousand stars how not to dance.e. e. cummingsIn a recently published conference on acute leukemia and Burkitt's tumor (1) there were 22 reports on epidemiology, immunology, biology, and pathology, and only 8 papers dealing primarily with clinical therapy. The selection of papers was not dictated by bias against therapists but reflected the phenomenal growth of preclinical studies in oncology and an equally impressive increase in the complexity of adequate clinical trials of new therapies. Since Farber and his coworkers (2) demonstrated the occasionally dramatic effect...References1. Symposium: Conference on acute leukemia and Burkitt's tumor. Cancer Res. 27: 2414, 1967. Google Scholar2. FARBERDIAMONDMERCERSYLVESTERWOLFF SLKRDRFJA: Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (Aminopterin). New. Eng. J. Med. 238: 787, 1948. CrossrefMedlineGoogle Scholar3. ZUBRODSCHEPARTZLEITERENDICOTTCARRESEBAKER CGSLKMLMCG: The chemotherapy program of the National Cancer Institute: history, analysis, and plans. Cancer Chemother. Rep. 50: 349, 1966. MedlineGoogle Scholar4. HERSHBODEYNIESFREIREICH EMGPBAEJ: Causes of death in acute leukemia: a ten year study of 414 patients from 1954-1963. JAMA 193: 105, 1965. CrossrefMedlineGoogle Scholar5. DJERASSIFARBEREVANS ISAE: Transfusion of fresh platelet concentrates to patients with secondary thrombocytopenia. New Eng. J. Med. 268: 221, 1963. CrossrefMedlineGoogle Scholar6. HANSTUTZMANCOHENKIM TLEU: An autopsy study on the effect of platelet transfusion on hemorrhage in patients with acute leukemia. Cancer 19: 1937, 1966. CrossrefMedlineGoogle Scholar7. HENDERSON ES: Combination chemotherapy of acute lymphocytic leukemia of childhood. Cancer Res. 27 (part 1): 2570, 1967. MedlineGoogle Scholar8. SELAWRY O: New treatment schedule with improved survival in childhood leukemia. JAMA 194: 75, 1965. CrossrefMedlineGoogle Scholar9. DJERASSIFARBERABIRNEIKIRK ISEW: Continuous infusion of methotrexate in children with acute leukemia. Cancer 20: 233, 1967. CrossrefMedlineGoogle Scholar10. VOGLERHUGULEYRUNDLES WRCMRW: Comparison of methotrexate with 6-mercaptopurine-prednisone in treatment of acute leukemia in adults. Cancer 20: 1221, 1967. CrossrefMedlineGoogle Scholar11. ELLISONSILVERENGLE RRRTRL: Comparative study of 6-chloropurine and 6-mercaptopurine in acute leukemia in adults. Ann. Intern. Med. 51: 322, 1959. LinkGoogle Scholar12. : Treatment of acute leukemia in adults: comparison of steroid and mercaptopurine therapy alone and in conjunction. Brit. Med. J. 1: 1383, 1966. CrossrefMedlineGoogle Scholar13. FREIFREIREICHGEHANPINKELHOLLANDSELAWRYHAURANISPURRHAYESJAMESROTHBERGSOCLEERUNDLESSCHROEDERHOOGSTRATTENWOLMANTRAGGISCOOPERGENDELEBAUGHTAYLOR EEJEDJFOFCLDMGWHDBRWLRBIJDGTBRFR: Studies of sequential and combination antimetabolite therapy in acute leukemia: 6-mercaptopurine and methotrexate. Blood 18: 431, 1961. CrossrefGoogle Scholar14. LEVINHENDERSONKARONFREIREICH RHEMEJ: Treatment of acute leukemia with methylglyoxal-bis-guanylhydrozone (Methyl GAG) Clin. Pharmacol. Ther. 6: 31, 1965. CrossrefMedlineGoogle Scholar15. BERNARDBOIRONHOLLANDJACQUILLATWEIL JMJFCM: Rubidomycin (daunomycin) in treatment of acute granulocytic leukemia (A.G.L.). Proc. Amer. Ass. Cancer Res. 9: 5, 1968. Google Scholar16. ELLISONHOLLANDSILVERBERNANDBOIRON RRJFRTJM: Cytosine arabinoside: a new agent for induction of remission in acute leukemia. Proceedings of the Ninth International Cancer Congress, Tokyo, 1966. Google Scholar17. HENDERSONSERPICKLEVENTHALHENRY EABP: Cytosine arabinoside infusions in adult and childhood acute myelocytic leukemia. Proc. Amer. Ass. Cancer Res. 9: 29, 1968. Google Scholar18. GEEYUAUGUSTINKRAKOFFCLARKSON TSBTBTIHBD: Combination therapy of adult acute leukemia with thioguanine (TG) and 1-beta-D-arabinofuranosylcytosine (CA). Proc. Amer. Ass. Cancer Res. 9: 23, 1968. Google Scholar19. FREIREICHBODEYHARRISHART EJGPJEJS: Therapy for acute granulocytic leukemia. Cancer Res. 27 (part 1): 2573, 1967. MedlineGoogle Scholar20. THOMPSONHALLMOLONEY ITCNC: Combination therapy of adult acute myelogenous leukemia: experience with the simultaneous use of vinenstine, amethopterin, 6-mercaptopurine and prednisone. New Eng. J. Med. 273: 1302, 1965. CrossrefMedlineGoogle Scholar21. HENDERSONSERPICK ESA: The effect of combination drug therapy and prophylactic oral antibiotic treatment in adult acute leukemia (abstract). Clin. Res. 15: 336, 1967. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDWARD S. HENDERSON, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA historical perspective on the development of the cytarabine (7days) and daunorubicin (3days) treatment regimen for acute myelogenous leukemia: 2013 the 40th anniversary of 7+3Challenges and opportunities in childhood cancer drug developmentPost-Remission Therapy for Acute Myelogenous LeukemiaAcute Nonlymphocytic Leukemia in the Elderly: Biology and TreatmentAdvances in the Treatment of Acute Myelogenous LeukemiaCombination chemotherapy of acute leukemia and lymphomaCytosine arabinoside and 6-thioguanine in the treatment of childhood acute myeloblastic leukemiaTowards a cure of acute granulocytic leukemia?Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanineThe Management of Acute Myelogenous LeukemiaFolate AntagonistsPROGNOSIS OF ACUTE LEUKÆMIA IN ADULTS *The Therapy of Acute Granulocytic Leukemia in Patients More Than Fifty Years OldVICTOR GRANN, M.D., F.A.C.P., ROBERT ERICHSON, M.D., F.A.C.P., JOHN FLANNERY, B.S., STUART FINCH, M.D., F.A.C.P., BAYARD CLARKSON, M.D., F.A.C.P.Combination Chemotherapy: Clinical ConsiderationsTreatment of acute myeloid leukemia of adults with cytosine arabinoside in combination with 6-mercaptopurineManagement of acute leukemiaCombination chemotherapy with cytosine arabinoside and rubidomycin in 30 cases of acute granulocytic leukemiaCURE AS THE AIM IN THERAPY FOR THE ACUTE LEUKÆMIASDaunorubicin therapy in adult acute lymphatic leukemiaThe Treatment of Acute Granulocytic Leukemia in AdultsTreatment of Acute Myeloid Leukaemia with Cytosine Arabinoside and Daunomycin in CombinationChemotherapy of acute leukaemiaAnti-Candida antibodies in patients with acute leukemiaConcurrent infectious mononucleosis and acute leukemiaTherapy of acute leukemia with drug combinations which include asparaginaseDAUNORUBICIN IN THE TREATMENT OF ADULT ACUTE LEUKAEMIAMegaloblastic Anemia of Pregnancy Simulating Acute LeukemiaPAUL H. LEVINE, M.D., ROGER D. HAMSTRA, M.D.Drug Therapy for Neoplastic Disease in AdultsTreatment of adult acute leukemia with arabinosylcytosine and thioguanine 1 September 1968Volume 69, Issue 3Page: 628-632KeywordsClinical epidemiologyClinical pathologyClinical trialsImmunology ePublished: 1 December 2008 Issue Published: 1 September 1968 PDF downloadLoading ...