tbuckley/cabot-search huggingface dataset:
Spurious automated red cell values in warm autoimmune hemolytic anemia
Authors: Gary B. Weiss, J. David Besman
Journal: American Journal of Hematology (1984)

Two patients with warm autoantibodies to their red cells had a mean cell volume artifactually elevated by red cell agglutination. Red cell size distribution histograms directly showed doublets and triplets of normal-size red cells. This phenomenon is similar to the spurious macrocytosis previously reported due to cold agglutinins, but was not reversible by warming.
Trans-rectal ultrasound guided prostate biopsy related sepsis: A DGH experience of fluoroquinolones
Authors: Harminder Sra, Philip Pastides, Rahul Lunawat, Barry Maraj
Journal: International Journal of Surgery (2011)

control. The control group comprised 71 consecutive patients in a 6 month period. New antimicrobial prophylaxis guidelines were introduced and 92 patients were then followed, with comparable profiles to the controls. The primary end-point was hospitalisation secondary to sepsis within a month. Results:The control regime consisted of 3 days of ciprofloxacin 500mg BD PO, and the new regime comprised Metronidazole 500mg PO prior to, and Gentamicin 160mg IV immediately before, the procedure. There were 4 (4.3%) cases of documented TRUS-biopsy related sepsis with the new regime compared to the one case (1.4%) in control group. All urine cultures were negative, though E.coli was the most frequent cause of urosepsis (50%) on blood cultures. Conclusion: Our study supports the use of fluoroquinolones as part of a prophylactic regime for TRUS biopsies of the prostate.
Human giant cell tumors of bone identification and characterization of cell types.
Authors: S R Goldring, M S Roelke, K K Petrison, A K Bhan
Journal: Journal of Clinical Investigation (1987)

Cells cultured from human giant cell tumors of bone were characterized on the basis of morphological features, proliferative capacity, presence of granulocyte-monocyte antigens, receptors for skeletal hormones, and soluble cell products. Three major cell types were identified. One population consisted of mononuclear cells with fibroblastic morphology, which proliferated in culture and most likely represent the neoplastic element of the tumor. Phenotypically they resembled a connective tissue stromal cell. A second population of mononuclear cells lacked receptors for skeletal hormones and did not persist in culture. These cells were likely of monocyte-macrophage lineage. A third population of cells consisted of large multinucleated giant cells. These cells possessed phenotypic features of osteoclasts including receptors for calcitonin. Human giant cell tumors of bone are most likely a neoplasm of connective tissue stromal cells, which have the capacity to recruit and interact with multinucleated giant cells that exhibit phenotypic features of osteoclasts.
The Radiation Effects Research Foundation of Hiroshima and Nagasaki
Authors: Itsuzo Shigematsu
Journal: JAMA (1995)

THE ATOMIC Bomb Casualty Commission (ABCC) was established in Hiroshima in 1947 and in Nagasaki in 1948 by the US National Academy of Sciences, National Research Council (NAS/NRC) based on President Truman's directive to initiate a long-term and comprehensive epidemiological and genetic study of the atomic bomb survivors.<sup>1</sup>The Japanese National Institute of Health under the Ministry of Health and Welfare joined the ABCC 1 year later to assist in the studies and improve the cooperation of the survivors. This arrangement continued for 28 years until it was replaced in 1975 by the Radiation Effects Research Foundation (RERF), a nonprofit Japanese foundation binationally managed and supported with equal funding by the governments of Japan, through the Ministry of Health and Welfare, and the United States, through the NAS/NRC under contract with the US Department of Energy (and its predecessors). Thanks to the cooperation of the survivors and the contributions
India may not meet millennium development goal on infant mortality
Authors: C. Travasso
Journal: BMJ (2015)

India’s infant mortality rate fell from 88 per 1000 live births in 1990 to 40 per 1000 live births in 2013, show reports from the Registrar General of India.1 But if the rate continues to decrease by 5.6% each year India will not be able to meet this year’s United Nations millennium development goal on infant mortality.

For India to meet the goal this year it will have had to cut the infant mortality rate by two thirds, …
Circulating CD14+CD204+ Cells Predict Postoperative Recurrence in Non–Small-Cell Lung Cancer Patients
Authors: Ryo Maeda, Genichiro Ishii, Shinya Neri, Kazuhiko Aoyagi, Hironori Haga, Hiroki Sasaki, Kanji Nagai, Atsushi Ochiai
Journal: Journal of Thoracic Oncology (2014)
Comparative sensitivity and specificity of Rb-82 pet and Ti-201 spect imagine in the diagnosis of coronary artery disease
Authors: Raymundo T. Go, William J. MacIntyre, Thomas H. Marwick, Conrad C. Simpfendorfer, Gopal B. Saha, Donald R. Neumann, Janet L. King, Donald A. Underwood
Journal: Journal of the American College of Cardiology (1990)
Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling
Authors: Fahsai Kantawong, Karl E.V. Burgess, Kamburapola Jayawardena, Andrew Hart, Richard J. Burchmore, Nikolaj Gadegaard, Richard O.C. Oreffo, Matthew J. Dalby
Journal: Biomaterials (2009)
Helper-independent mink cell focus-inducing strains of Friend murine type-C virus: potential relationship to the origin of replication-defective spleen focus-forming virus.
Authors: D H Troxler, E Yuan, D Linemeyer, S Ruscetti, E M Scolnick
Journal: The Journal of Experimental Medicine (1978)

Recent studies have indicated that both the replication-defective spleen focus-forming virus (SFFV) in the Friend virus complex and the helper-independent mink cell focus-inducing (MCF) viruses derived from AKR-murine leukemia virus (MuLV) are env gene recombinants between ecotropic virus and xenotropic virus. In an attempt to isolate additional env gene recombinants between Friend murine leukemia virus (F-MuLV) and xenotropic virus, we have inoculated cloned ecotropic F-MuLV into newborn NIH Swiss mice and analyzed MuLV released from preleukemic and leukemic spleens of infected mice. Two helper-independent MCF strains of F-MuLV have been isolated. Like the previously described AKR-MCF viruses, the Friend MCF viruses are env gene recombinants between an ecotropic virus (F-MuLV) and a mouse xenotropic virus, as shown by host range, interference pattern, and tryptic peptide analysis of the gp70s of these MuLV. Furthermore, RNA from the Friend MCF viruses hybridizes completely to cDNAsffv, a nucleic acid probe which detects that portion of SFFV which was not derived from P-MuLV. The ability to isolate replicating MCF viruses derived from F-MuLV FURTHER strengthens the parallels between the Friend erythroleukemia system and the AKR thymic leukemia system. Finally, the potential relationship of helper-independent env gene recombinants between F-MuLV and xenotropic virus to be highly leukemogenic SFFV is discussed.
Maternal Depression and Child Development After Prenatal DHA Supplementation
Authors: Johanna Assies
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
Authors: Abhishek Das, Matthew Hoare, Nathan Davies, A. Ross Lopes, Claire Dunn, Patrick T.F. Kennedy, Graeme Alexander, Helene Finney, Alistair Lawson, Fiona J. Plunkett, Antonio Bertoletti, Arne N. Akbar, Mala K. Maini
Journal: The Journal of Experimental Medicine (2008)

The inflamed liver in chronic hepatitis B virus (HBV) infection (CHB) is characterized by a large influx of non–virus-specific CD8 T cells. Little is known about the functional capacity of these lymphocytes, which could provide insights into mechanisms of failure of viral control and liver damage in this setting. We compared the effector function of total circulating and intrahepatic CD8 T cells in CHB patients and healthy donors. We demonstrated that CD8 T cells from CHB patients, regardless of their antigen specificity, were impaired in their ability to produce interleukin-2 and proliferate upon TCR-dependent stimulation. In contrast, these CD8 T cells had preserved production of the proinflammatory cytokines interferon-γ and tumor necrosis factor-α. This aberrant functional profile was partially attributable to down-regulation of the proximal T cell receptor signaling molecule CD3ζ, and could be corrected in vitro by transfection of CD3ζ or replenishment of the amino acid arginine required for its expression. We provide evidence for depletion of arginine in the inflamed hepatic microenvironment as a potential mechanism for these defects in global CD8 T cell signaling and function. These data imply that polarized CD8 T cells within the HBV-infected liver may impede proliferative antiviral effector function, while contributing to the proinflammatory cytokine environment.
The Distinctive Cardiovascular Lesion of Ankylosing Spondylitis: A Study of 8 Necropsy Patients.
Authors: Bernadine H. Bulkley
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973The Distinctive Cardiovascular Lesion of Ankylosing Spondylitis: A Study of 8 Necropsy Patients.Bernadine H. Bulkley, M.D., William C. Roberts, M.D.Bernadine H. Bulkley, M.D.Search for more papers by this author, William C. Roberts, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-834_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough aortic regurgitation has been described previously in patients with ankylosing spondylitis, the distinctive morphologic features of the cardiovascular lesion have not been defined. All eight patients had combined spondylitis and aortic regurgitation; one also had Reiter 's syndrome. All were men (age, 34-55 years), all had severe congestive heart failure, and all had evidence of joint involvement consistent with ankylosing spondylitis. Six had conduction disturbances. All died at an average of 6 years after the onset of congestive heart failure. In at least three patients signs of valvular dysfunction (murmur) antedated or coincided with the earliest arthritic symptoms. The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Bernadine H. Bulkley, M.D.; William C. Roberts, M.D.Affiliations: Bethesda, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 834-834KeywordsAnkylosing spondylitisHeart failureLesionsSpondylitis ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
Revalidation: the real life OSCE
Authors: R. Harrison
Journal: BMJ (2002)

Consultants love a good OSCE, and if objective structured clinical examinations are good enough for assessing medical students then they should be good enough for assessing consultants, although they must reflect a typical working day. The OSCE outlined here is designed for the revalidation of middle aged, male doctors, but it can easily be adjusted for age, sex, and specialty.

Station 1

Neurology

Not unreasonably you ask for an ophthalmoscope to examine the retina of a young man with sudden unilateral visual failure. Sister goes off and returns with one from the urology ward. There is no light and it rattles. Sister goes off again and finds you two batteries. There is still no light. Sister goes off again. She does not return. Examine the other cranial nerves.

Station 2

Radiography

The teacher with an early term dizzy turn, nausea, and headache who underwent computed tomography of her head on the medical admission unit two days ago is agitating for the result, in a fierce sort of way—as is her solicitor husband, in a medicolegal sort of way. With an air of calm authority garnered from years at the top you take control, promising to see the scans immediately and “sort everything out.” Your senior house officer (she looks vaguely familiar and you're pretty sure that's who …
1121-59 Immediate and mid-term results of the treatment of in-stent restenosis with sirolimus-eluting stents
Authors: Renata Rogacka, Flavio Airoldi, Alaide Chieffo, Goran Stankovic, Matteo Montorfano, Mauro Carlino, Jassen Michev, Ghada Mikhail, Antonio Colombo
Journal: Journal of the American College of Cardiology (2004)
Blockade of CD28 by a synthetical peptoid inhibits T-cell proliferation and attenuates graft-versus-host disease
Authors: Na Li, Faliang Zhu, Fei Gao, Qun Wang, Xiaoyan Wang, Haiyan Li, Chunhong Ma, Wensheng Sun, Wenfang Xu, Chaodong Wang, Lining Zhang
Journal: Cellular and Molecular Immunology (2010)
Peptic ulceration and gastrointestinal bleeding in pancreatitis.
Authors: I N Marks, S Bank, J H Louw, J Farman
Journal: Gut (1967)

EDITORIAL COMMENT Acute gastrointestinal bleeding has been present in 20% of this large series but in only a few of these can it be attributed to chronic peptic ulceration.The wide variety of causes is commented upon in this paper.Radiological evidence of peptic ulceration is not unusual in patients with pancreatitis.This, coupled with the not infrequent occurrence of gastrointestinal bleeding in pancreatitis, has led many to believe that a high incidence of peptic ulceration exists in patients with this condition (Warren and Cattell, 1959; Fitzgerald, Fitzgerald, Fennelly, McMullin, and Boland, 1963; Howard and Jordan, 1960; Zollinger, Elliot, Endahl, Grant, Goswitz, and Taft, 1962; Eyler, Clark, and Rian, 1962).Others, on the other hand, have reported a low incidence of ulceration in patients with pancreatitis (Marks and Bank, 1963).The purpose of the present paper is to re-examine the incidence of peptic ulceration in pancreatitis, to draw attention to the fact that the radiological changes in pancreatitis may mimic peptic ulceration, and to analyse the causes of gastrointestinal bleeding in patients with pancreatic disease.
The role of basophil activation test in special populations with mastocytosis and reactions to hymenoptera sting
Authors: P. Bonadonna, R. Zanotti, G. Melioli, F. Antonini, I. Romano, L. Lenzi, B. Caruso, G. Passalacqua
Journal: Allergy (2012)

Abstract Background Systemic mastocytosis ( SM ) may be associated with hymenoptera allergy. In such cases, immunotherapy is a life‐saving treatment, but a circumstantiated diagnosis is needed for its prescription. Patients with SM and previous reactions to stings, but with negative tests represent a diagnostic dilemma. The basophil activation test ( BAT ) may be helpful in refining the diagnosis. Objective We assessed the usefulness of BAT in subpopulations of mastocytosis patients, including those with negative tests for insect allergy. Methods Within a population of patients with mastocytosis and previous stings, we studied by BAT and augmented intradermal test ( IDT ) (10 µg/ml) two groups: (1) with reactions to stings and negative tests; (2) without reactions and negative tests. Basophil activation test was performed with different venoms, assessing at flow cytometry basophils’ activation. Results Sixty‐three patients had mastocytosis and 52 had reactions to previous hymenoptera stings. Of them, seven proved negative to diagnostic tests. In six of seven of those patients, BAT was negative with all venoms, and in one, basophils resulted activated also with the negative control. In six patients without previous reactions and negative tests, BAT was totally negative in five of six patients and weakly positive to Hornet in one. Finally, the IDT at 10 µg/ml venom produced nonspecific positive results in most cases. Conclusion In patients with mastocytosis, the negative results of standard tests are reliable, because BAT and IDT at higher concentration do not add useful information.
Cardiac function in Ghanaian children with severe malaria
Authors: Samuel B. Nguah, Torsten Feldt, Steffi Hoffmann, Daniel Pelletier, Daniel Ansong, Justice Sylverken, Parisa Mehrfar, Johanna Herr, Christian Thiel, Stephan Ehrhardt, Gerd D. Burchard, Jakob P. Cramer
Journal: Intensive Care Medicine (2012)
Distribution of Acute Leukaemia in Time and Space. Studies in New Zealand
Authors: B. Wharton, G. Howells, I. Phillips
Journal: BMJ (1968)

The distribution of leukaemia in time and space was examined by tracing the date of onset and the place of residence in all cases of childhood leukaemia and of acute leukaemia in adults, totalling 1,003 cases, which occurred in New Zealand during the 12 years from 1953 to 1964.Significant seasonal variations in the onset were found in adults but not in children. Time-space clustering did not occur in adults, but a significant tendency towards it was found in children aged less than 6 years. Since a similar tendency has previously been found by two other groups of investigators it is suggested that leukaemia in young children may have a different aetiology from that occurring at other ages.
Chemokine-receptor activation by env determines the mechanism of death in HIV-infected and uninfected T lymphocytes
Authors: Stacey R. Vlahakis, Alicia Algeciras-Schimnich, German Bou, Carrie J. Heppelmann, Angelina Villasis-Keever, Ronald G. Collman, Carlos V. Paya
Journal: Journal of Clinical Investigation (2001)

There is considerable confusion concerning the mechanism of lymphocyte death during HIV infection. During the course of HIV infection, M-tropic viruses (R5) that use CCR5 chemokine coreceptors frequently evolve to T-tropic viruses (X4) that use CXCR4 receptors. In this study we show that activation of the CD4 or CCR5 receptor by R5 HIVenv causes a caspase 8–dependent death of both uninfected and infected CD4 T cells. In contrast, CXCR4 activation by X4 HIVenv induces a caspase-independent death of both uninfected CD4 and CD8 T cells and infected CD4 cells. These results suggest that activation of the chemokine receptor by HIVenv determines the mechanism of death for both infected and uninfected T lymphocytes.
Homogenous Groups as Treatment Modality for Anorectics
Authors: E.L. Edelstein, E. Moguilner
Journal: Psychotherapy and Psychosomatics (1986)

The accumulated amount of research studies on anorexia has not until now produced a clear understanding of its etiology, symptoms and treatment. In this paper we deal with one aspect of the symptomatology: the delusion on the part of the anorectic patient of being normal or overweight. This issue, which seems the most obnoxious, is dealt with and discussed through a psychological model of group therapy with the participation of 7 anorectic women. Implications and limitations of further psychological treatment are clarified and revised.
Muir–Torre syndrome caused by partial duplication of MSH2 gene by Alu-mediated nonhomologous recombination
Authors: K. Yanaba, H. Nakagawa, Y. Takeda, N. Koyama, K. Sugano
Journal: British Journal of Dermatology (2007)

We describe a 54-year-old man with a pedicled tumour on the neck. The surgical specimen revealed a sebaceous carcinoma. He belonged to a cancer-prone family susceptible to gastrointestinal cancer. Systemic evaluation for latent malignancies revealed early-stage colonic adenocarcinoma. These findings were compatible with Muir–Torre syndrome (MTS). Microsatellite instability was detected in the sebaceous carcinoma, suggesting a DNA mismatch repair gene mutation. Moreover, duplication of exon 7 generated a nonsense codon at codon 427 of the MSH2 gene causing truncation of MSH2 protein. Immunohistochemical analysis showed diminished MSH2 protein levels in the sebaceous carcinoma and colonic adenocarcinoma. To date, there have been no reports showing duplication of exon 7 of the MSH2 gene in MTS or hereditary nonpolyposis colorectal cancer kindreds. Furthermore, the present case indicates that the dermatologist plays an important role in the diagnosis of MTS and evaluation for latent malignancies.
Efficacy and safety of yttrium-90 ibritumomab tiuxetan in patients with relapsed or refractory diffuse large B-cell lymphoma not appropriate for autologous stem-cell transplantation
Authors: Franck Morschhauser, Tim Illidge, Damien Huglo, Giovanni Martinelli, Giovanni Paganelli, Pier Luigi Zinzani, Simon Rule, Anna Marina Liberati, Noel Milpied, Georg Hess, Harald Stein, Joachim Kalmus, Robert Marcus
Journal: Blood (2007)
Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference
Authors: Jordi Bruix, Morris Sherman, Josep M Llovet, Michel Beaugrand, Riccardo Lencioni, Andrew K Burroughs, Erik Christensen, Luigi Pagliaro, Massimo Colombo, Juan Rodés
Journal: Journal of Hepatology (2001)
Dietary Fiber, Glycemic Load, and Risk of Non—insulin-dependent Diabetes Mellitus in Women
Authors: Jorge Salmerón
Journal: JAMA (1997)

<h3>Objective.</h3> —To examine prospectively the relationship between glycemic diets, low fiber intake, and risk of non—insulin-dependent diabetes mellitus. <h3>Desing.</h3> —Cohort study. <h3>Setting.</h3> —In 1986, a total of 65173 US women 40 to 65 years of age and free from diagnosed cardiovascular disease, cancer, and diabetes completed a detailed dietary questionnaire from which we calculated usual intake of total and specific sources of dietary fiber, dietary glycemic index, and glycemic load. <h3>Main Outcome Measure.</h3> —Non—insulin-dependent diabetes mellitus. <h3>Results.</h3> —During 6 years of follow-up, 915 incident cases of diabetes were documented. The dietary glycemic index was positively associated with risk of diabetes after adjustment for age, body mass index, smoking, physical activity, family history of diabetes, alcohol and cereal fiber intake, and total energy intake. Comparing the highest with the lowest quintile, the relative risk (RR) of diabetes was 1.37 (95% confidence interval [CI], 1.09-1.71,<i>P</i>trend=.005). The glycemic load (an indicator of a global dietary insulin demand) was also positively associated with diabetes (RR=1.47; 95% CI, 1.16-1.86,<i>P</i>trend=.003). Cereal fiber intake was inversely associated with risk of diabetes when comparing the extreme quintiles (RR=0.72,95% CI, 0.58-0.90,<i>P</i>trend=.001). The combination of a high glycemic load and a low cereal fiber intake further increased the risk of diabetes (RR=2.50, 95% CI, 1.14-5.51) when compared with a low glycemic load and high cereal fiber intake. <h3>Conclusions.</h3> —Our results support the hypothesis that diets with a high glycemic load and a low cereal fiber content increase risk of diabetes in women. Further, they suggest that grains should be consumed in a minimally refined form to reduce the incidence of diabetes.