tbuckley/cabot-search huggingface dataset:
Cell surface antigens of human renal cancer defined by autologous typing.
Authors: R Ueda, H Shiku, M Pfreundschuh, T Takahashi, L T Li, W F Whitmore, H F Oettgen, L J Old
Journal: The Journal of Experimental Medicine (1979)

Sera from 28 patients with renal cancer were tested for reactivity with surface antigens of cultured autologous renal cancer cells. Four serological assays were used to survey sera for autologous antibody. Immune adherence, protein A, and C3-mixed hemadsorption assays detected reactivity in a high percentage of patients (80-100%), whereas mixed hemadsorption assays were negative with sera from all but one patient. Reactive sera from six patients were analyzed by absorption tests with autologous, allogeneic, and restricted to autologous renal cancer cells; class 2 antigens, present on certain allogeneic renal and nonrenal cancer cells; and class 3 antigens, found on a wide variety of normal and malignant cell types. The sera of one patient detected class 1, 2, and 3 antigens, the sera of three patients detected class 2 antigens, and the sera of two patients detected class 3 antigens. This analysis of renal cancer, with the recognition of three classes of surface antigens recognized by autologous sera, resembles the results of autologous typing of three other human malignancies: malignant melanoma, acute leukemia, and astrocytoma. Evidence provided by autologous typing of these cancers indicates that class 1 and class 2 antigens are tumor-restricted and that under certain circumstances these antigens are immunogenic for the autologous host.
Clinicopathological correlations in cor pulmonale.
Authors: P M Calverley, R Howatson, D C Flenley, D Lamb
Journal: Thorax (1992)

BACKGROUND: The relation between pulmonary disease and physiological abnormality in patients with hypoxic cor pulmonale is controversial and the association between arterial hypoxaemia and right ventricular hypertrophy has been challenged. To address these problems matched patients treated with and without domiciliary oxygen were studied. METHODS: Necropsy data were obtained on 19 patients (14 male), 10 of whom had been treated with domiciliary oxygen. Pulmonary artery pressure and total pulmonary vascular resistance as well as blood gas tensions during the breathing of air and oxygen were available for the six months before death. Formalin fixed lung slices were assessed for panacinar and centriacinar emphysema. Right and left ventricular weights were measured and their ratio (LV&amp;S/RV) was used as an index of right ventricular hypertrophy. Carotid body weights were available in 14 cases. RESULTS: Fourteen patients died of respiratory failure and antemortem thrombus was found in the pulmonary arteries of eight cases. Physiological measurements were unrelated to the degree of macroscopic emphysema, pulmonary hypertension, or daytime blood gas tensions. When allowance was made for the higher "ambient" arterial oxygen tension (PaO2) of those who had oxygen, PaO2 was correlated with LV&amp;S/RV (r = 0.79), absolute right ventricular weight (r = -0.53), and carotid body weight (r = 0.68). CONCLUSIONS: These data show that in hypoxic cor pulmonale in vivo physiological disturbances are poor indicators of the underlying disease process. The relation of "ambient" PaO2 to right ventricular hypertrophy and carotid body weight suggests that domiciliary oxygen therapy might lead to regression of such established disease.
The Relation of Endemic Goiter to Mental Deficiency
Authors: O. P. KIMBALL
Journal: Annals of Internal Medicine (1930)

Article1 December 1930The Relation of Endemic Goiter to Mental DeficiencyO. P. KIMBALL, M.D., J. CARLTON MARINUS, M.D.O. P. KIMBALL, M.D.Search for more papers by this author, J. CARLTON MARINUS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-6-569 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEndemic goiter has occupied a prominent place in medical literature from the time of our earliest medical writings. We also find references to this age old disease in our ancient manuscripts.We have definite records of cretins since early Roman history, but it was not until the beginning of the 16th century that the Swiss physician, Paracelsus, described cretinism in detail and emphasized the relation of cretinism to endemic goiter. In 1800, appeared Fodere's basic essay on "Goiter and Cretinism", in which he states that "Goiter is the first degree of a degenerative process in which cretinism is the last...Bibliography BAUER J: Die Diagnose der Schildruseninsuffizienz, Wiener klinische Wochenschrift, 1927, No. 45. Google Scholar CROTTI A: Thyroid and Thymus, 1918. Google Scholar EGGENBERGER H: Kropf und Kretinismus, pp. 903. Google Scholar EISENBERG W: Endocrine disturbance in feeblemindness Ztschrift. f. Kinderforsch. April, 1929, 35:373. Google Scholar HOPENER T: Ergebenisse Kapillarmikroskopisher Untersuchungen an 3100 Casseller Kindern, Deutsche Zeitschrift fur Nervenheikunde. Jan. 1929, pp. 218. Google Scholar JAENACHWITTNEBEN WW: Archicappilaren, Endokrines System und Schwachsinn. Verlagsbuchhanddlung. 1926, Julius Springer, Berlin. Google Scholar OLIN R: Iodine deficiency and prevention of simple goiter in Michigan, Mich. Dept. of Health, Reprints. May 10, 1924. Google Scholar GUDAKUNST DW: Verbal report from Detroit School Records. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTherapeutic concepts relating to hypothyroidism in childhoodEndemic Goiter—A Food Deficiency DiseaseSocial adjustment of hypothyroid children 1Basal Metabolism and the College Freshman Psychological TestNinth Annual Meeting of the American Academy of PediatricsStudies of Miscellaneous Physical ConditionsChapter VI: Physically and Mentally Exceptional ChildrenHypothyroidism as a Factor in MaladjustmentChapter VI: Relationships in Physical and Mental DevelopmentThe effect of thyroid deficiency upon skull growth in the sheepGOITRE PROPHYLAXIS 1 December 1930Volume 4, Issue 6Page: 569-577KeywordsIntellectual disability Issue Published: 1 December 1930 PDF DownloadLoading ...
Don't Learn on Me — Are Teaching Hospitals Patient-Centered?
Authors: Brendan M. Reilly
Journal: New England Journal of Medicine (2014)

Interview with Professor Brendan Reilly on teaching hospitals' balancing of their educational and patient care missions. (12:27)Download When a patient at a U.S. teaching hospital says she wants no trainees involved in her care, do we tell her to go elsewhere? Transfer her to the nonteaching service? Or somehow convince her that she will receive better care on the teaching service?
Confessions of a technophile
Authors: Kinesh Patel
Journal: BMJ (2011)

I’ve got a confession to make: I like The Archers . This tale of everyday village folk on BBC Radio 4 is strangely compelling. I’ve been listening for about 20 years. But rather than tune in six days a week, I prefer the Sunday omnibus edition, with all the week’s episodes in one broadcast.⇑

This, however, rather interrupts my Sunday morning snooze, so six or seven years ago I used to program the family stereo system to turn itself on and begin to record onto a cassette tape, which I would then …
Portal hypertension in Waldenstrom's macroglobulinaemia.
Authors: A P Brooks
Journal: BMJ (1976)

ResultsThe figure summarises results for the Arabs and Africans.'For all results (t=407; DF=30; P<0001), and also when the perfusion segment was proximal (t=272; DF=22; P<002), the difference was significant (Student's t test).Mean net water absorption rate in the Arabs was 4 49 (2 30-7-44) ml/30 cm of jejunum/min and in the Africans 1-88 (-1-15-4-72) ml/30 cm of jejunum/min; this difference was significant (t=4 99; DF=30; P<0O001).E 5 - 0 0 0, i 0 0~~0 0+ ~~~~~~~00 E 5 0 0 0~~~00 C 0 * 0 o 0~~~~~~~( D 0-5- 0~~~~~~Saudi Arabia Zambia Glucose absorption-rates (mmol/30 cm jejunum/min).Means (± SE of mean) are indicated.0 = Infusion < 20 cm past duodenojejunal flexure. 0= Infusion >20 cm past duodeno- jejunal flexure.
Non-therapeutic excision of the foreskin
Authors: A. D. Lempert
Journal: BMJ (2010)

I welcome the Dutch Medical Association’s call to end ritual circumcision.1 Clinically unnecessary surgical excision of normal genital skin violates a child’s human right to an intact body and to be protected from harm.

A 2007 study showed that circumcision ablates the most sensitive parts of the penis.2 There is a risk of further harm …
Competition in the NHS has saved lives, study indicates
Authors: N. Hawkes
Journal: BMJ (2010)

Competition in the NHS in England has saved lives and reduced lengths of stay in hospital, a new study says.

Patients who were treated in hospitals in areas where competition was feasible did better than those in areas where there was less competition, say the researchers, from Bristol University, Carnegie Mellon University in Pittsburgh, Pennsylvania, and Imperial College London. 

Lives were saved, length of stay in hospital was reduced, and costs did not increase, they found.

The introduction in the NHS of “patient choice” (the right of patients to choose the hospital in which they are treated) and of the payment by results system, by which hospitals are paid according to the activities they …
Tennis injuries: occurrence, aetiology, and prevention
Authors: B M Pluim, J B Staal, G E Windler, N Jayanthi
Journal: British Journal of Sports Medicine (2006)

A systematic search of published reports was carried out in three electronic databases from 1966 on to identify relevant articles relating to tennis injuries. There were 39 case reports, 49 laboratory studies, 28 descriptive epidemiological studies, and three analytical epidemiological studies. The principal findings of the review were: first, there is a great variation in the reported incidence of tennis injuries; second, most injuries occur in the lower extremities, followed by the upper extremities and then the trunk; third, there have been very few longitudinal cohort studies that investigated the association between risk factors and the occurrence of tennis injuries (odds ratios, risk ratios, hazard ratios); and fourth, there were no randomised controlled trials investigating injury prevention measures in tennis. More methodologically sound studies are needed for a better understanding of risk factors, in order to design useful strategies to prevent tennis injuries.
AFTER THROMBOLYSIS FOR ACUTE MYOCARDIAL INFARCTION CULPRIT VESSEL REVASCULARIZATION IN PATIENTS WITH VIABILITY IN THE INFARCT AREA LEADS TO A SIGNIFICANT IMPROVEMENT IN EJECTION FRACTION WHEN COMPARED TO A MEDICAL, NON-INVASIVE MANAGEMENT
Authors: Gerrit Veen, Ramon van Loon, Otto Kamp, Albert C. van Rossum
Journal: Journal of the American College of Cardiology (2013)
Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection
Authors: Bruce L. Levine, Wendy B. Bernstein, Naomi E. Aronson, Katia Schlienger, Julio Cotte, Steven Perfetto, Mary J. Humphries, Silvia Ratto-Kim, Deborah L. Birx, Carolyn Steffens, Alan Landay, Richard G. Carroll, Carl H. June
Journal: Nature Medicine (2002)
Effectiveness of Emergency Room Care.
Authors: Robert H. Brook
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Effectiveness of Emergency Room Care.Robert H. Brook, M.D., Morris H. Berg, B.A., Philip A. Schechter, B.A.Robert H. Brook, M.D.Search for more papers by this author, Morris H. Berg, B.A.Search for more papers by this author, Philip A. Schechter, B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-855_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUrban emergency rooms are being required to care for an increasing number of patients with non-emergency conditions. Little is known about their capability to respond to this demand. This study evaluated the care received by 166 consecutive patients with subacute or chronic gastrointestinal symptoms. These patients were seen in the Johns Hopkins Hospital Emergency Room, Baltimore, Md., and were referred for either barium enema, upper gastrointestinal series, or an oral cholecystogram. Using data obtained from a chart review and patient interview, the adequacy of the process of medical care and change in functional capacity during the 4 months after the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert H. Brook, M.D.; Morris H. Berg, B.A.; Philip A. Schechter, B.A.Affiliations: Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5 Page: 855-855 Keywords Charts Emergency department ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Rupture of posterior wall of left ventricle after mitral valve replacement.
Authors: J H Dark, W H Bain
Journal: Thorax (1984)

Possible aetiological factors, presentation, and management were reviewed in 18 patients with posterior left ventricular rupture complicating mitral valve replacement seen at one centre over six and a half years. The patients were elderly (mean age 57), predominantly women (16 of the 18), and suffering from mitral stenosis. Rupture was much more common after isolated replacement of the mitral valve (16 out of 797 operations) than after double valve replacement (one out 236) or mitral valve replacement and coronary artery bypass graft (one out of 70). A total of 1221 mitral valve replacements were performed over this period, with an overall incidence of rupture of 1.47%. Damage to the valve annulus occurred five times. On four occasions haemorrhage followed a vigorous response to a bolus dose of an inotrope. With the exception of these features, it was difficult to define specific risk factors. Eleven patients bled while still in theatre; one of them survived long term and another four lived for four to 10 days. Repair after restarting cardiopulmonary bypass made short term survival much more likely. In seven rupture developed after return to the intensive therapy unit; again only one survived long term. In nearly all cases bleeding was at, or just below, the atrioventricular groove. Rupture probably occurs after endocardial damage to a thin myocardium that has lost the internal buttress of the subvalvar apparatus. With the rise in intraventricular pressure at the end of bypass blood dissects into the myocardium, resulting in a large haematoma and eventual rupture.
Appendiceal Schwannoma Detected by FDG-PET/CT
Authors: Masami Nishio, Tsuneo Tamaki, Masaki Hara, Yuta Shibamoto
Journal: Clinical Nuclear Medicine (2010)

We report the FDG-PET/CT findings in a patient with an appendiceal schwannoma. The incidence of appendiceal neoplasm in patients in whom appendectomy was performed is low and ranges from 0.6% to 0.8%. Schwannoma is extremely rare among them. We describe a 71-year-old man without symptoms who had continued yearly health screening including FDG-PET/CT for 3 years. The initial FDG-PET/CT demonstrated an intense uptake superimposed to the appendix. We recommended a surgical intervention with a malignant nature in mind. However, he refused surgery with the risk of deterioration of his heart disease. Under these circumstances, a yearly check-up was performed. Two years later, an increased FDG accumulation was observed and he agreed to have a surgical resection. Histopathological examination confirmed a diagnosis of appendiceal schwannoma.
Torsion of testis.
Authors: J. A. Burton
Journal: BMJ (1969)

<h3>Objective:</h3> To investigate the relationship between years of ice hockey play and risk for CTE neuropathology at autopsy. <h3>Background:</h3> Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts (RHI) including from contact sports and military service. Previous work showed a dose-response relationship between CTE risk and severity and years of American football play. A similar dose-response relationship for ice hockey has not been investigated. <h3>Design/Methods:</h3> 74 consecutive brain donors who played ice hockey from the Veterans Affairs-Boston University-Concussion Legacy Foundation and Framingham Heart Study Brain Banks [age range: 13–91; highest level of play: 7 (9%) youth, 25 (34%) high school, 22 (30%) juniors/college, 19 (26%) professional (1 unknown); 34 (46%) played an additional contact sport, including 32 (43%) who played American football] were assessed for CTE diagnosis, stage (0–IV) and cumulative neurofibrillary tangle burden across 11 brain regions commonly affected by CTE (range: 0–33). We estimated the association of duration of ice hockey play in years with each neuropathological outcome in linear models adjusted for age at death and duration of football play. <h3>Results:</h3> 40 donors were diagnosed with CTE (54%). A dose-response relationship was observed between duration of ice hockey play and each outcome. Each additional year of play corresponded to a 23% increase in odds for having CTE (95% CI: 11%–36%; p&lt;0.01), a 15% increase in odds for increasing one CTE stage (95% CI: 8%–22%; p&lt;0.01), and a 0.03 SD increase in cumulative NFT burden (95% CI: 0.01–0.05; p&lt;0.01). When limited to those who played hockey as their primary source of exposure (n=56), results remained similar. <h3>Conclusions:</h3> This is the first study to find a dose-response relationship between years of ice hockey play and CTE risk and severity. Increasing ice hockey play may pose an increasing risk for CTE in a similar manner as American football play. <b>Disclosure:</b> Bobak Abdolmohamadi has nothing to disclose. Madeline Uretsky has nothing to disclose. Mr. Nair has nothing to disclose. Nicole Saltiel has nothing to disclose. Raymond Nicks has nothing to disclose. Daniel Daneshvar has nothing to disclose. Victor E Alvarez, 5394 has nothing to disclose. Bertrand Huber has nothing to disclose. Dr. Stein has nothing to disclose. Dr. McKee has nothing to disclose. The institution of Michael Alosco, PHD has received research support from NIH. The institution of Dr. Mez has received research support from NIH, DOD.
Body fat distribution, relative weight, and liver enzyme levels: A population-based study
Authors: Saverio Stranges, Joan M. Dorn, Paola Muti, Jo L. Freudenheim, Eduardo Farinaro, Marcia Russell, Thomas H. Nochajski, Maurizio Trevisan
Journal: Hepatology (2004)

Regional body fat distribution may represent an independent risk factor for several conditions, especially metabolic and cardiovascular diseases; recent findings have shown that abdominal fat accumulation can be an independent predictor of hepatic steatosis. Very few studies, mostly using selected clinical samples, have focused on the relationship between indices of abdominal visceral fat accumulation and the most commonly used biochemical liver tests, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT). The aim of the present study was to evaluate the relation between central fat accumulation, as assessed by abdominal height, relative weight, as determined by body mass index (BMI), and liver function tests (ALT, AST, and GGT) in a random sample of 2,704 residents of Erie and Niagara Counties in New York State, 35-80 years of age and free from known hepatic disease. Multiple linear regression models were used, with liver enzymes as dependent variables with abdominal height and BMI as independent variables, and the inclusion of several covariates (age, race, education, smoking status, pack-years of smoking, drinking status, and total ounces of ethanol in the past 30 days). Abdominal height was consistently a better correlate of ALT and GGT levels than BMI in both sexes. In addition, abdominal height was the most powerful independent predictor of ALT in both sexes as well as of GGT among women. In conclusion, these findings support a role for central adiposity independent from BMI in predicting increased levels of hepatic enzymes, likely as a result of unrecognized fatty liver.
Semiquantitative grading of severity of mitral regurgitation by real-time two-dimensional Doppler flow imaging technique
Authors: Kunio Miyatake, Shiro Izumi, Mitsunori Okamoto, Naokazu Kinoshita, Hirohiko Asonuma, Hiroshi Nakagawa, Katsuhiro Yamamoto, Makoto Takamiya, Hiroshi Sakakibara, Yasuharu Nimura
Journal: Journal of the American College of Cardiology (1986)
Muslims with non-insulin dependent diabetes fasting during Ramadan: treatment with glibenclamide.
Authors: J Belkhadir, H el Ghomari, N Klocker, A Mikou, M Nasciri, M Sabri
Journal: BMJ (1993)

OBJECTIVE--To compare the efficacy of two glibenclamide regimens in patients with non-insulin dependent diabetes who were fasting during Ramadan and regular glibenclamide treatment in the non-fasting group. DESIGN--Non-randomised control group of patients who did not fast during Ramadan and two groups of patients who fasted randomised equally to one of two regimens: to take their usual morning dose of glibenclamide in the evening and their usual evening dose before dawn; or to follow this pattern but to reduce the total dose by a quarter. SETTING--Two university hospitals, one private hospital, and two private clinics in Casablanca and Rabat, Morocco. SUBJECTS--591 diabetic patients (198 men, 391 women, two unspecified) with similar duration of diabetes and length and amount of glibenclamide treatment, of whom 542 completed the study. MAIN OUTCOME MEASURES--Serum fructosamine and total glycated haemoglobin concentrations and number of hypoglycaemic events. RESULTS--At the end of Ramadan there were no significant differences between the groups in fructosamine concentration (400 mumol/l in controls and 381 mumol/l and 376 mumol/l in the fasting groups); percentage of glycated haemoglobin (14.7%, 14.0%, and 13.6%); or number of hypoglycaemic events during Ramadan (11, 14, and 10). CONCLUSION--Glibenclamide is effective and safe for patients with non-insulin dependent diabetes who fast during Ramadan. The easiest regimen is to take the normal morning dose (together with any midday dose) at sunset and any evening dose before dawn.
Isolated Incompetence of the Pulmonic Valve
Authors: BEN O. PRICE
Journal: Circulation (1961)

Two cases of isolated incompetence of the pulmonic valve diagnosed during life are reported and a review of the literature is presented. The diagnosis should be suspected in patients with a basal diastolic murmur and right ventricular enlargement who have no evidence of other cardiac valvular disease. The characteristic murmur associated with isolated incompetence of the pulmonic valve appears to be related to filling of the dilated right ventricle. The diagnosis can be confirmed clinically by right heart catheterization. The lesion is not benign in the human being, and right ventricular failure may be precipitated when complicating diseases are present.
Preparing a Child for a Good-bye Visit to a Dying Loved One
Authors: Judith S. Rubenstein
Journal: JAMA (1982)

DEATH is never easy to explain to children, particularly younger ones. Experts may compound the problem by giving parents vague generalizations, such as "explain death honestly to the child," without suggesting specific phrases to use. The parents still remain at a loss for words and may feel even worse than they did before they received the advice, because now they think they should know what to say. Preparing a child for a "good-bye" visit to a dying loved one is an aspect of death that probably has received the least attention. It is not customary, in the United States, to take a child on such a visit. The epitome of this exclusion may be found in "Gone With the Wind": when Melanie is dying, all of the most meaningful people in her life get to say good-bye to her, except her child. When my father-in-law was dying of cancer, my