Membranous Glomerulonephritis in Two Human Renal Homotransplants
Authors: JOHN P. O'BRIEN
Journal: Annals of Internal Medicine (1966)

Article1 September 1966Membranous Glomerulonephritis in Two Human Renal HomotransplantsJOHN P. O'BRIEN, M.D., DAVID M. HUME, M.D.JOHN P. O'BRIEN, M.D.Search for more papers by this author, DAVID M. HUME, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-3-504 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHealthy kidneys transplanted to an identical twin who suffers from chronic glomerulonephritis frequently show the signs and morphology of chronic glomerulonephritis (1-3). In these cases there seems to have been a recrudesence of a diffuse glomerulonephritis which was previously active in the recipient. It has been suggested that some nephritogenic substance, possibly circulating antibody, contributes to the activity of the disease in the transplant. Prophylactic nephrectomy has been advocated because such a substance might be specifically related to the diseased renal tissue (1). In contrast, glomerulonephritis occurring in homotransplants treated continuously with immunosuppressive drugs to avoid rejection is distinctly rare....References1. MURRAYMERRILLHARRISON JEJPJH: Transplantation between seven pairs of identical twins. Ann. Surg. 148: 343, 1958. CrossrefMedlineGoogle Scholar2. PFEIFFERMERRILL EFJP: Die autoagression in der pathogenese der diffusen glomerulonephritis. Deutsch. Med. Wschr. 87: 934, 1962. CrossrefMedlineGoogle Scholar3. HUMEMERRILLMILLERTHORN DMJPBFGW: Experiences with renal homotransplantation in the human. J. Clin. Invest. 34: 327, 1955. CrossrefMedlineGoogle Scholar4. PORTERTHOMPSONOWENKENYONMOWBRAYPEART KAWBKJRJFWS: Obliterative vascular changes in four human kidney homotransplants. Brit. Med. J. 2: 639, 1963. CrossrefMedlineGoogle Scholar5. HAMBURGERCROSNIERDORMONT JJJ: Observations in patients with a well tolerated homotransplanted kidney; possibility of a secondary disease. Ann. N. Y. Acad. Sci. 120: 558, 1964. CrossrefMedlineGoogle Scholar6. KRIEGBOLANDEHOLDENHUBAYPERSKY AFRPWDCAL: Membranous glomerulonephritis occurring in a human renal homograft. Amer. J. Clin. Path. 34: 155, 1960. CrossrefMedlineGoogle Scholar7. MICHONHAMBURGEROCCONOMOSDELINIATTERICHETVAYSSEANTOINE LJNPGJB: Une tentative de transplantation renale chez l'homme: aspects medicale et biologiques. Press. Med. 61: 1419, 1953. MedlineGoogle Scholar8. BERMANSCHREINER LBGE: Clinical and histologic spectrum of the nephrotic syndrome. Amer. J. Med. 24: 249, 1958. CrossrefMedlineGoogle Scholar9. HUMELEEPROUTBOWERWOLFSLAPAK DMHMGRJDJSM: Renal homotransplantation in man: studies in 63 cases. Ann. Surg. In press, 1966. MedlineGoogle Scholar10. ZUKOSKIENDE CFN: Membranous glomerulonephritis complicating prolonged survival of a homografted kidney. Transplantation 3: 118, 1965. CrossrefMedlineGoogle Scholar11. RUSSELLMONACO PSAP: The biology of tissue transplantation. New Eng. J. Med. 271: 502, 533, 610, 664, 718, 776, 1964. CrossrefMedlineGoogle Scholar12. PORTERCALNEZUKOSKI KARYCF: Vascular and other changes in 200 canine renal homotransplants treated with immunosuppressive drugs. Lab. Invest. Part II, 13: 809, 1963. Google Scholar13. STARZLMARCHIOROTERASAKPORTERFARISHERMANNVEDEVOHUTTOGDENWADDELL TETLPIKATDTJDLPMDAWR: Chronic survival after human renal homotransplantation. Ann. Surg. 162: 749, 1965. CrossrefMedlineGoogle Scholar14. KUSSLEGRAINMATHENEDEYCAOMEY RMGRM: Homotransplantation renale chez l'homme hors de tour lien de parente: Survie jusqu' au dix-septieme mois. Rev. Franc. Etud. Clin. Biol. 7: 1048, 1962. MedlineGoogle Scholar15. HAMBURGERVAYSSECROSNIERAUVERTLALANNEHOPPER JJJJCMJ: Renal homotransplantation in man after radiation of the recipient. Experience with six patients since 1959. Amer. J. Med. 32: 854, 1962. CrossrefMedlineGoogle Scholar16. MURRAYMERRILLDAMMINDEALYALEXANDREHARRISON JEJPGJJBGWJH: Kidney transplantation in modified recipients. Ann. Surg. 156: 337, 1962. CrossrefMedlineGoogle Scholar17. MURRAYMERRILLHARRISONWILSONDAMMIN JEJPJHREGJ: Prolonged survival of human-kidney homografts by immunosuppressive drug therapy. New Eng. J. Med. 268: 1315, 1963. CrossrefMedlineGoogle Scholar18. GOODWINKAUFMANMIMSTURNERGLASSCOCKGOLDMANMAXWELL WEJJMMRDRRMM: Human renal transplantation. I. Clinical experiences with six cases of renal homotransplantation. J. Urol. 89: 13, 1963. CrossrefMedlineGoogle Scholar19. PARSONMARKLANDRAPERFOX FMCFPM: Cadaveric renal transplantation. Brit. Med. J. 1: 930, 1963. CrossrefGoogle Scholar20. EHRENREICHOLMSTEAD TEV: Malignant hypertension following the administration of cortisone in periarteritis nodosa. Arch. Path. (Chicago) 52: 145, 1951. MedlineGoogle Scholar21. ZUELZERPALMERNEWTON WWHDWA: Unusual glomerulonephritis in young children, probably radiation nephritis. Amer. J. Path. 26: 1019, 1950. MedlineGoogle Scholar22. VALLERY-RADOTMAURICEWOLFROMMGUIOT PGRG: Nephrose l'poidique secondarire a un traitment aurique. Bull. Mem. Soc. Med. Hop. Paris. 58: 96, 1942. Google Scholar23. ALLEN AC: The clinicopathologic meaning of the nephrotic syndrome. Amer. J. Med. 18: 277, 1955. CrossrefMedlineGoogle Scholar24. HUMEMAGEEPROUTCLEVELANDBOWERLEE DMJHGRRJJDHM: Studies of renal homotransplantation in man. Ann. N. Y. Acad. Sci. 120: 578, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN P. O'BRIEN, M.D.; DAVID M. HUME, M.D.Affiliations: Richmond, VirginiaFrom the Departments of Medicine and Surgery, Medical College of Virginia, Richmond, Va.This study was supported in part by research grant HE 08203 (Clinical Transplant Center), U. S. Public Health Service, Bethesda, Md., and grant MO 1 FR 65-04 (Clinical Research Center), National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to David M. Hume, M.D., Chairman, Department of Surgery, Medical College of Virginia, Richmond, Va. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDe novo membrano-proliferative glomerulonephritis in a renal allograftDe novo membranous nephropathy in human renal allografts: Report of nine patientsGlomerular Lesions in Renal AllograftsGlomerulopathies in Human Renal AllograftsMembranous glomerulonephritis: Current statusGlomerulopathy in the Transplanted KidneyRelationship Between Original Renal Disease and Fate of Renal AllograftsOrgan Transplantation, Past and PresentProteinuria and Nephrotic Syndrome Associated with Chronic Rejection of Kidney TransplantsHuman Tissue Transplantation 1 September 1966Volume 65, Issue 3Page: 504-510KeywordsElectron microscopyGlomerulonephritisMedical servicesMonozygotic twinsNephrectomyProteinuriaRenal diseasesResearch grantsSurgeryTransplantation ePublished: 1 December 2008 Issue Published: 1 September 1966 PDF downloadLoading ...