tbuckley/cabot-search huggingface dataset:
Interpretation of Ventricular Ectopy
Authors: NORMAN KRASNOW
Journal: Annals of Internal Medicine (1980)

Letters1 July 1980Interpretation of Ventricular EctopyNORMAN KRASNOW, M.D.NORMAN KRASNOW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-1-149 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Kennedy and colleagues (1) have contributed important data to the etiologic interpretation of complex ventricular ectopy in apparently healthy persons. Only six of 25 subjects had significant coronary artery disease (> 50% luminal narrowing), despite a high frequency of hyperlipidemia, hypertension, and cigarette smoking as risk factors. Analysis of results of maximal exercise testing, morphology of ectopic beats on 24-hour ambulatory electrocardiography, or angiographic data did not help identify those subjects with underlying heart or coronary artery disease. The authors therefore conclude that ventricular ectopy, even complex forms, is "unrelated to significant covert coronary heart disease in...Reference1. KENNEDYPESCARMONABOUCHARDGOLDBERG HJRR. Coronary artery status of apparently healthy subjects with frequent and complex ventricular ectopy. Ann Intern Med. 1980;92(Part 1):179-85. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: State University of New York Downstate Medical Center Brooklyn, NY 11203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1980Volume 93, Issue 1_Part_1Page: 149-150KeywordsCoronary heart diseaseElectrocardiographyExerciseHyperlipidemiaHypertensionMedical risk factorsStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 July 1980 PDF downloadLoading ...
Mondor's Disease and String Phlebitis
Authors: Daniel J. Abramson
Journal: JAMA (1966)

MONDOR'S DISEASE, or string phlebitis of the chest wall, is relatively unknown, often unrecognized, and infrequently reported. The development of a fibrous cord in the region of the breast is of great concern to the patient. Therefore, it is important that this lesion be recognized as benign and selflimited and not as an indication of malignancy. The following cases draw attention to this entity and its clinical features. Methods of treatment, including the forcible snapping of the band, will be described. (Priority for this technique is given to Frederick Y. Donn, MD, Washington, DC, who initially used this procedure [F. Y. Donn, personal communication]. ) <h3>Report of Cases</h3><h3>Case 1.—</h3> A 32-year-old Negro woman complained of soreness and a band in the right outer chest wall, that had been present for two weeks. She was eight weeks post partum. A fibrous cord was found in the outer quadrant of the breast,
The Chinese herbal formula, MSSM-002, can reverse the established Th2 phenotype, which is accompanied with down regulation of the th2 transcription factor GATA-3
Authors: Xiu-Min Li, Ariel Teper, Zhong-Mei Zou, Kamal D Srivastava, Brian H Schofield, Hugh A Sampson
Journal: Journal of Allergy and Clinical Immunology (2002)
SPECIFIC CUTANEOUS REACTIONS AND CIRCULATING ANTIBODIES IN THE COURSE OF LOBAR PNEUMONIA
Authors: Maxwell Finland, W. D. Sutliff
Journal: The Journal of Experimental Medicine (1931)

1. Characteristic cutaneous responses to the type-specific protein-free carbohydrates of both Type I and Type II pneumococci have been "produced" in cases of lobar pneumonia due to either of these types by the intravenous injection of concentrated bivalent (Types I and II) antipneumococcic sera (Felton). 2. A positive cutaneous response to the specific polysaccharide of Type II pneumococci has been passively transferred from human cases convalescing from this infection to a patient suffering from pneumonia due to this organism. 3. The cutaneous responses to the type-specific polysaccharides and circulating antibodies were studied in 51 cases of lobar pneumonia. Positive cutaneous reactions were, in most instances, associated with recovery, even when purulent complications were present. Failure to elicit a positive reaction was usually followed by a fatal outcome. 4. The positive reactions in patients who were treated with concentrated sera and recovered were most often elicited within 24 hours after the first dose and after a total of 40 cc. had been given. 5. The positive skin reactions obtained after the administration of specific antisera were associated with the presence of mouse protective antibodies and agglutinins in the sera of the patients. 6. The immune reactions in serum treated cases receiving repeated inoculations with the specific carbohydrates disappeared more rapidly than in similar cases receiving no antiserum. It is suggested that the administration of antisera in someway interferes with the production of antibodies by the intracutaneously injected carbohydrates.
USE OF MEPHENOXALONE IN BEHAVIORAL PROBLEMS
Authors: IRVIN A. KRAFT
Journal: American Journal of Psychiatry (1962)

Mephenoxalone appears to be a useful medication for cases demonstrating 14 and 6 per second spikings. Its activity warrants further investigation in the areas of brain damage, especially in the so-called diffuse brain damaged child. Mephenoxalone was used in 31 children with various diagnoses. It proved helpful in 2 types of therapy: drug-symptom focused and psychotherapy-drug adjunctive. Improvement of excellent and good ratings was achieved in 55% of the former and 75% of the latter groups.
Differences in Access to Liver Transplantation: Disease Severity, Waiting Time, and Transplantation Center Volume
Authors: Jawad Ahmad, Cindy L. Bryce, Thomas Cacciarelli, Mark S. Roberts
Journal: Annals of Internal Medicine (2007)

Background: The Model for End-Stage Liver Disease (MELD) score has been used since February 2002 to allocate livers for transplantation from deceased donors according to medical need. Allocation based on MELD scores should ensure that sicker patients receive transplants first regardless of transplantation center volume. Objective: To determine whether the MELD score at transplantation and waiting time of liver transplant recipients differs by transplantation center volume. Design: Analysis of the Organ Procurement and Transplantation Network database. Centers were classified according to the volume of transplantations performed in 2005: high (≥100 transplantations), medium (50 to 99 transplantations), and low (<50 transplantations). Setting: Transplantation centers in the United States. Patients: 20 075 transplant recipients between 27 February 2002 and 30 April 2006. Measurements: MELD scores and waiting times of liver transplant recipients. Results: Transplant recipients at high-volume centers had lower MELD scores (35.1% with MELD scores ≤18 vs. 22.7% and 27.0% at medium- and low-volume centers, respectively; P < 0.001), and the median MELD score was 22 compared with 24 at both medium- and low-volume centers. Despite having lower MELD scores, recipients at high-volume centers also experienced shorter waiting times (median waiting time, 69 days vs. 98 days and 94 days at medium-and low-volume centers, respectively; P < 0.001). Limitations: The definition of transplantation center volume was subjective. The recent implementation of MELD precluded analysis of differences in long-term outcomes related to waiting time or center volume. Conclusions: The MELD scores and waiting time of liver transplant recipients differed by transplantation center volume. High-volume centers have shorter waiting times and perform more transplantations for less sick patients. The reasons for these differences are unclear but warrant further investigation.
Reply to Karol Polom, Dawid Murawa, Wojciech Polom's Letter to the Editor re: Henk G. van der Poel, Tessa Buckle, Oscar R. Brouwer, Renato A. Valdés Olmos, Fijs W.B. van Leeuwen. Intraoperative Laparoscopic Fluorescence Guidance to the Sentinel Lymph Node in Prostate Cancer Patients: Clinical Proof of Concept of an Integrated Functional Imaging Approach Using a Multimodal Tracer. Eur Urol 2011;60:826–33
Authors: Henk G. van der Poel, Oscar R. Brouwer, Nynke S. van den Berg, Tessa Buckle, Fijs W.B. van Leeuwen
Journal: European Urology (2011)
Screening Donated Blood and Plasma for HTLV-III Antibody
Authors: Michael T. Osterholm, Robert J. Bowman, Michael W. Chopek, J. Jeffrey McCullough, Jack A. Korlath, Herbert F. Polesky
Journal: New England Journal of Medicine (1985)

Little question remains that the causative agent of the acquired immunodeficiency syndrome (AIDS) is the newly recognized retrovirus, human T-cell lymphotropic virus Type III (HTLV-III).1 2 3 4 5 AIDS, the AIDS-related complex, and asymptomatic HTLV-III infection have been associated with several well-defined high-risk groups, including recipients of blood and blood products.6 7 8 Protection of our nation's blood and plasma supply from HTLV-III contamination has been one of the highest public health priorities related to the AIDS epidemic.Studies of symptomatic and asymptomatic members of high-risk groups indicate that those who are infected with HTLV-III are also likely to be positive for HTLV-III antibody.3 , 9 10 11 Tests . . .
Expression of Wnt4 in Human Pituitary Adenomas Regulates Activation of the β-Catenin-Independent Pathway
Authors: Takashi Miyakoshi, Mao Takei, Hanako Kajiya, Noboru Egashira, Susumu Takekoshi, Akira Teramoto, Robert Yoshiyuki Osamura
Journal: Endocrine Pathology (2008)
Medical vs Legal Definitions of Death
Authors: M. Martin Halley
Journal: JAMA (1968)

Legal and medical definitions of death are not characterized by intrinsic uniformity or scientific exactness. The legal definition of death is also not necessarily identical with the ordinary medical definition of death and is inconsistent with extraordinary medical definitions. The legal definition appears as an inclusive concept, involving cessation of all vital functions, cessation of respiration, cessation of circulation, and impossibility of resuscitation. Potential conflicts should be anticipated and resolved through interprofessional cooperative action, with emphasis on precise definitions identical in both law and medicine. An interdisciplinary definition of death is proposed as a basis for further discussion.
Childhood vulval pemphigoid: a clinical and immunopathological study of five patients
Authors: None FARRELL, None KIRTSCHIG, None DALZIEL, None ALLEN, None DOOTSON, None EDWARDS, None WOJNAROWSKA
Journal: British Journal of Dermatology (1999)

We describe five girls with vulval pemphigoid: two had bullous pemphigoid confined to the vulva and three had cicatricial pemphigoid. They demonstrate a spectrum of severity from localized disease to extensive vulval scarring necessitating long-term immunosuppressive therapy and surgical correction. The age at onset of their disease ranged between 6 and 13 years. All presented with vulval discomfort and erosions. Three had oral lesions, two perianal and one eye and cutaneous involvement. Two girls with only vulval lesions and one with vulval and oral lesions responded well to topical steroids. In two, systemic treatment with prednisolone and dapsone or azathioprine was required. The diagnosis was made on the basis of histology and immunofluorescence (IF). All had positive direct IF with IgG and C3. Indirect IF demonstrated circulating IgG binding to the basement membrane zone in four, with dermal or epidermal binding on salt-split skin substrate. Immunoblotting revealed antibodies to the BP230 and BP180 antigens. Immunoelectron microscopy in the child with dermal binding IgG and BP180 and BP230 on immunoblotting showed labelling at the lamina densa-lamina lucida interface adjacent to hemidesmosomes.
THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE
Authors: Richard M. Pearce, J. H. Austin, John H. Musser
Journal: The Journal of Experimental Medicine (1912)

The results of this study of the changes in the blood after splenectomy and of the effect of the administration of hemolytic serum allow the following tentative conclusions: 1. The failure of a hemolytic serum to cause jaundice is due in some way to the anemia which frequently follows splenectomy. Animals, whether splenectomized or not, which have a low blood count and low hemoglobin content do not readily develop jaundice after administration of a hemolytic serum. On the other hand, in animals with a normal blood picture such a serum readily causes, during early periods after splenectomy, a well marked jaundice. 2. The difficulty of producing hemoglobinemia and jaundice in animals splenectomized one month or more, is due, as shown by blood count, the use of hypotonic salt solution test, and by the search for the presence of hemoglobin in the serum and urine, to an increase in the resistance of the red cells. The results of detailed serologic tests upon this point will be presented later. 3. It is possible that spontaneous jaundice occurring at long periods after splenectomy is an accompaniment of the complete regeneration of the blood. The study of the blood in animals splenectomized for long periods, seven to ten months, indicates that spontaneous jaundice occurs only when the animal has recovered from the initial period of anemia and has a high red cell count and high hemoglobin content. 4. As to the mechanism responsible for the anemia following splenectomy and for the increased resistance of the red cells, we can at present offer no explanation.
Pregnancy, with Accidental Hæmorrhage; Difficult to Control and Difficult in the Diagnosis.
Authors: John M. Batten
Journal: JAMA (1889)

<h3>Dear Sir:</h3> —The following case seems to me to be of special interest: Mrs. P., æt. 30 years, mother of five children and had had three miscarriages. Her mother died of disease of some one of the abdominal organs. Mrs. P. had her last monthly period the latter part of last July. On September 24, whilst sitting in a carriage watching a procession passing by, she was taken suddenly with uterine hæmorrhage and was carried into a drug store in a fainting condition. On November 20 she had recurrence of the hæmorrhage, and also on December 21. I saw her first on November 20. On December 29 she had another hæmorrhage. At this time she took to her bed and remained there. The hæmorrhage never afterwards totally ceased. January 1, 1889, patient had profuse hæmorrhage; also January 16 and 21. On the morning of January 23 I tamponed in order
A piece of my mind. I of the storm
Authors: P. S. Butterfield
Journal: JAMA (1990)

John was admitted through the emergency department on a brilliantly clear autumn afternoon. A healthy kid from an upper middle-class neighborhood, he had run in a high school cross-country track meet the previous afternoon. That night he'd awakened complaining of a fever and headache. By the time his physician saw him the next afternoon, the boy was severely purpuric from fulminating meningococcemia. He was referred to our emergency department and admitted to intensive care almost immediately. From the day he arrived, John's situation was special. As rarely happens in a tertiary-care center, John's disease and the medical complications arising from it were overshadowed by the human context and consequences of his situation. Its impact rippled out from the intensive care unit. By Friday, 2 days after he was admitted, even people who had never met him were asking, "How's the kid in the unit?" This was not just banal curiosity
Prediction of relapse by day 100 BCR-ABL quantification after allogeneic stem cell transplantation for chronic myeloid leukemia
Authors: V Asnafi, M-T Rubio, E Delabesse, E Villar, F Davi, G Damaj, I Hirsch, N Dhédin, J P Vernant, B Varet, A Buzyn, E Macintyre
Journal: Leukemia (2006)
VERY STALE, VERY SOFT
Authors: HARVEY E. FINKEL
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 September 1969VERY STALE, VERY SOFTHARVEY E. FINKEL, M.D.HARVEY E. FINKEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-3-668_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I would suggest that the dis-interest of internists in postgraduate training in psychiatry may be attributed to the first two words of the title of your editorial, "Stale, Soft, or Chronic" (Ann. Intern. Med. 70: 1272, 1969). Psychiatric instruction is, in most cases, stale and very, very soft. Despite decades of background, experimental studies, and clinical observations upon which data (facts, not theories, even if simple clinical descriptions—see Kraeplin) are based are rarely adequately controlled. The skeptic is often asked to take things on faith.This leads to the problem of apparent disinterest. Practicing internists do not... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARVEY E. FINKEL, M.D.Affiliations: 77 Warren St. Brighton, Mass. 02135 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1969Volume 71, Issue 3Page: 668-668KeywordsObservational studiesResidency ePublished: 1 December 2008 Issue Published: 1 September 1969 PDF downloadLoading ...
Association of seropositivity for hepatitis viruses and aplastic anemia in Thailand
Authors: S Issaragrisil, D Kaufman, A Thongput, K Chansung, T Thamprasit, A Piankijagum, T Anderson, S Shapiro, P Leaverton, N S Young
Journal: Hepatology (1997)

Aplastic anemia is more common in the Orient than in western countries, with an incidence in Thailand that is 2- to 3-fold higher than in Europe. Aplastic anemia after hepatitis is a well characterized clinical entity, and clinical hepatitis is also prevalent in the Far East. We performed a prospective case-control study to determine risk factors for aplastic anemia in Bangkok and two rural regions during 1989 to 1994. A total of 375 cases were identified, along with 1,174 hospital controls matched for age and sex. Historical data were collected by trained interviewers. Sera from a subset of cases (N = 177) and controls (N = 183) were tested for antibodies to hepatitis viruses A, B, and C and hepatitis B surface antigen. There was no evidence of association of aplastic anemia with hepatitis B or hepatitis C. Previous exposure to hepatitis A, as determined by immunoglobulin G (IgG) seropositivity, was significantly associated with aplastic anemia: the relative risk adjusted for confounding was 2.9 (95% confidence interval 1.2-6.7). The same association also existed for persons under age 25 years, in whom the prevalence of hepatitis A IgG was lower than in the total population. However, no patients showed evidence of recent infection with hepatitis A (immunoglobulin M [IgM] seropositivity). These results indicate that exposure to a hepatitis virus is a risk indicator for aplastic anemia in Thailand, and while itself unlikely to be etiologic, hepatitis A may be a surrogate marker for another enteric microbial agent.
No Evidence of an Emerging Physician Surplus
Authors: William B. Schwartz
Journal: JAMA (1990)

Analysis of physicians' work patterns and income between 1982 and 1987 provides strong evidence that the demand for physicians' services has risen at least as quickly as physician supply. Aggregate hours spent by US physicians who provide patient care rose by 21%, and aggregate real net income rose by more than 30% during a period in which the supply of physicians grew by only 16%. The aggregate number of visits rose by only 9%, indicating that the time spent per patient encounter rose sharply, presumably as a result of technological change and the increased complexity of care. Recently released data for 1988 are consistent with these trends. Our findings are inconsistent with the prediction by the Graduate Medical Education National Advisory Committee that there would be a large physician surplus by the year 1990. Moreover, if the upward trend in demand for physicians' services continues, as seems probable, a physician surplus should not develop in the foreseeable future. Only extensive rationing of beneficial services would be expected to alter this projection.
Androgen Deprivation Therapy and Competing Risks
Authors: William K. Kelly, Leonard G. Gomella
Journal: JAMA (2011)

among patients receiving ADT vs control was 11.0% (95% CI, 8.3%-14.5%) vs 11.2% (95% CI, 8.3%-15.0%), respectively, and the corresponding relative risk (RR) was not significant (0.93; 95% CI, 0.79-1.10; P=.41). The duration of ADT (long duration [3 years] vs short duration [6 months]) was not associated with increased cardiovascular death. An important additional finding was that ADT comparedwithcontroltreatmentwasassociatedwithlowerprostatecancer–specificmortality(13.5%vs22.1%;RR,0.69;95% CI, 0.56-0.84; P.001) and all-cause mortality (37.7% vs 44.4%; RR, 0.86; 95% CI, 0.80-0.93; P.001). These data should give confidence to treating physicians andpatientsthatuseofADTamongpatientswithunfavorablerisk,nonmetastaticprostatecancerdoeshaveasignificantclinicalbenefitwithoutasignificantincreaseincardiovascularmortality.However,thisstudyonlyevaluatedcardiovasculardeaths and sheds little light on the issue of the development or acceleration of cardiovascular disease. The latter may be more of a concern because data from the National Prostate Cancer Register in Sweden found the RR of nonfatal and fatal cardiovascular disease was increased in all men with prostate cancer. 9 Thisincreasedriskwasevenobservedinmenundersurveillance with the risk further increased with ADT. 9 Although the study by Nguyen et al 8 appears to directly contradict the findings of some prior reports, 4-6 an important consideration is that this analysis evaluated the use of
Admission to Medical School
Authors: Henry K. Silver
Journal: JAMA (1982)

DEANS and associate deans for admissions of state-supported schools of medicine are frequently contacted by individuals who indicate, but do not declare outright, that certain applicants to medical school should receive "thorough consideration" (do they mean "special consideration" or "preference?") when these applicants come up for review for admission to medical school. The deans and associate deans often have great sympathy for the arguments given for an applicant to receive "thorough consideration," but they usually cannot, and feel they should not, do anything to influence the admissions process, since the faculty and others involved in the process are (and necessarily should be) precluded from giving special consideration to anyone except under guidelines established by state and federal regulations or under overall university or medical school policy. I wonder whether those who contact deans or admissions committee personnel would, overall, be any more satisfied if special consideration actually were given to