tbuckley/cabot-search huggingface dataset:
Expression of Heat Shock Protein 27 in Human Atherosclerotic Plaques and Increased Plasma Level of Heat Shock Protein 27 in Patients With Acute Coronary Syndrome
Authors: Haing Kee Park, Eui-Chul Park, Sung Won Bae, Mi Young Park, Seon Woon Kim, Hwan Soo Yoo, Munkhtsetseg Tudev, Young Hye Ko, Yoon-Ho Choi, Sungjoo Kim, Dong-Ik Kim, Young Wook Kim, Byung Boong Lee, Jong-Bok Yoon, Jeong Euy Park
Journal: Circulation (2006)

We intended to identify proteins that are differentially expressed in human atherosclerotic plaques.Comparative 2-dimensional electrophoretic analysis on carotid atherosclerotic endarterectomy specimens (n = 10) revealed that heat shock protein 27 (Hsp27) expression was significantly increased in the nearby normal-appearing area compared with the plaque core area from the same vessel specimen, which was further confirmed by Western blot analysis. The Hsp27 expression in the adjacent normal-appearing vessel areas was much higher than that in nonatherosclerotic reference arteries. The phosphorylation of Hsp27 showed a gradation in the degree of phosphorylation: greatest in the reference arteries, intermediate in the adjacent normal-appearing area, and lowest in plaque core area. Immunohistochemical analysis showed that the phosphorylation of Hsp27 of smooth muscle cells in the carotid endarterectomy specimens was decreased compared with that in the reference artery specimen. The mean plasma level of Hsp27 was significantly higher in patients with acute coronary syndrome (ACS) (n = 27; 106.1 +/- 74.1 ng/mL) than in the normal reference subjects (n = 29; 45.8 +/- 29.5 ng/mL; P < 0.005). The plasma levels of Hsp27 were significantly correlated with those of heat shock protein 70 (Hsp70) (r = 0.422, P < 0.0005), with adjustment for ACS/reference status.In the atherosclerotic lesion, Hsp27 expression is increased in the normal-appearing vessel adjacent to atherosclerotic plaque, whereas levels in the plaque itself are significantly decreased. Both plaque and adjacent artery show decreased Hsp27 phosphorylation compared with reference vessel. In ACS, plasma Hsp27 and Hsp70 are increased, and levels of Hsp27 correlate with Hsp70, C-reactive protein, and CD40L levels.
Treatment of onychomycosis with terbinafine
Authors: F. BAUDRAZ-ROSSELET, T. RAKOSI, P.B. WILI, R. KENZELMANN
Journal: British Journal of Dermatology (1992)

An open multicentre trial was conducted by 40 dermatologists in Switzerland involving 188 patients with onychomycosis of either the toenails or fingernails. Of these patients, 145 who had positive microscopy and culture of dermatophyte infection were evaluable: of the dermatophytes identified at the initial visit, 80% were Trichophyton rubrum and 12.4% were T. mentagrophytes. Only the most affected nail was evaluated during the obsevration period. Daily dosage was 250 mg of terbinafine (Lamisil®) orally for up to 6 months. The cure rate (negative microscopy and culture) at the end of treatment was 77% for toenails and 100% for fingernails. A follow-up investigation was made 6 months after the end of treatment: of the 88 patients examined with onychomycosis of the toenail and the 14 with fingernail onychomycosis, 90.9% and 85.7%, respectively, remained free of recurrence. Of the 26 patients who had shown improvement, but not cure, by the end of the treatment period, 15 were clinically and mycologically cured at the time of the follow-up investigation. Terbinafine was generally well tolerated: the most frequent drug-related adverse events were mild-to-moderate gastrointestinal disturbances. Changes in liver or renal biochemical tests were not considered clinically relevant.
Spontaneous Intramural Hematoma of the Esophagus
Authors: Ajay Chawla, Michael H. Blume, Jerald Insel
Journal: Annals of Internal Medicine (2002)

Letters2 July 2002Spontaneous Intramural Hematoma of the EsophagusAjay Chawla, MD, Michael H. Blume, MD, and Jerald Insel, MDAjay Chawla, MDGood Samaritan Hospital; Baltimore, MD 21239 (Chawla, Blume, Insel)Search for more papers by this author, Michael H. Blume, MDGood Samaritan Hospital; Baltimore, MD 21239 (Chawla, Blume, Insel)Search for more papers by this author, and Jerald Insel, MDGood Samaritan Hospital; Baltimore, MD 21239 (Chawla, Blume, Insel)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-1-200207020-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Spontaneous intramural hematoma of the esophagus is an uncommon cause of acute odynophagia. It can result in chest pain, dysphagia, and hematemesis (1). We report a case of a man with hemophilia and partial factor VIII deficiency who presented with sudden onset of acute odynophagia and substernal chest pain radiating to the anterior chest and shoulder. The patient did not report a history of emesis, trauma, ingestion of nonsteroidal anti-inflammatory drugs, or gastrointestinal bleeding episodes. His vital signs were stable, and results of liver and kidney function tests were normal. His initial prothrombin time was 44 seconds; ...References1. Oldenburger D, Gundlach WJ. Intramural esophageal hematoma in a hemophiliac. An unusual cause of gastrointestinal bleeding. JAMA. 1977;237:800. [PMID: 299897] CrossrefMedlineGoogle Scholar2. Kerr WF. Spontaneous intramural rupture and intramural haematoma of the oesophagus. Thorax. 1980;35:890-7. [PMID: 6973833] CrossrefMedlineGoogle Scholar3. Shay SS, Berendson RA, Johnson LF. Esophageal hematoma. Four new cases, a review, and proposed etiology. Dig Dis Sci. 1981;26:1019-24. [PMID: 7028429] CrossrefMedlineGoogle Scholar4. Hiller N, Zagal I, Hadas-Halpern I. Spontaneous intramural hematoma of the esophagus. Am J Gastroenterol. 1999;94:2282-4. [PMID: 10445563] CrossrefMedlineGoogle Scholar5. Ackert JJ, Sherman A, Lustbader IJ, McCauley DI. Spontaneous intramural hematoma of the esophagus. Am J Gastroenterol. 1989;84:1325-8. [PMID: 2801687] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Good Samaritan Hospital; Baltimore, MD 21239 (Chawla, Blume, Insel) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIntramural haematoma of the oesophagusCricopharyngeal Intramural Hematoma: An Unusual Complication of Orthopedic InterventionHematoma esofágico gigante: posible relación con dosis pequeñas de aspirina 2 July 2002Volume 137, Issue 1Page: 73-74KeywordsComputed axial tomographyEndoscopyEsophagusHemophiliaHemorrhageIschemiaMagnetic resonance imagingShouldersThoraxVital signs ePublished: 2 July 2002 Issue Published: 2 July 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Letter: Treatment of acute gout.
Authors: P A Bacon, A J Collins, E F Ring
Journal: BMJ (1974)

published in the near fuutre.6The pre- liminary results of in vitro lipid haemodialysis utilizing '4C-imipramine indicate a clearance of approximately 20 to 40 ml/min, depending on the type of filter, dialysate, and blood-line system used.-Weare, etc.,
P82 Effect Of A Standardised Chest Clearance Pathway On Quality Of Life And Hospital Admissions In Patients With Non Cystic Fibrosis Bronchiectasis
Authors: L. Yeo, K. Bentley, Z. Borrill
Journal: Thorax (2014)

<h3></h3> British Thoracic Society guidelines for non-cystic fibrosis bronchiectasis (NCFB) recommend airway clearance taught by a physiotherapist for patients with chronic sputum production or mucus plugging on CT. Various techniques and adjuncts are available and the evidence for the effectiveness of these is inconsistent. We designed a stepwise chest clearance pathway for use in a specialist NCFB clinic in a large district general hospital trust. Patients were taught and commenced on active cycle breathing technique with postural drainage, positive expiratory pressure device, mucolytic and nebulised hypertonic saline, progressing to each step until chest clearance was felt to be optimised. Quality of life was assessed using Leicester cough questionnaire (LCQ) at baseline and after each intervention including the point of optimisation. Hospital admission and general practice antibiotic prescription data were retrospectively collected for 12 months pre and post initiation of the pathway. Data were compared using Wilcoxon signed rank test. 105 patients (mean age 67, 53 female, mean FEV1 1.62l) were included although data were incomplete. Total LCQ score significantly improved at the point where chest clearance was felt to be optimised, compared to baseline, with a median difference of 1.3. Subgroup analysis revealed that patients with lower baseline LCQ showed greater improvement. Further analysis revealed that all steps in the pathway resulted in significant improvements in LCQ with the exception of mucolytics. Hospital admissions for NCFB were significantly reduced in the 12 months following initiation of the pathway. There was no significant difference in antibiotic usage according to GP prescriptions. This retrospective study suggests that the use of a standardised chest clearance pathway may result in improved quality of life and reduction in hospital admissions in patients with NCFB.
Reduced Postprandial Hyperglycemia After Subcutaneous Injection of a Somatostatin-Analogue (SMS 201-995) in Insulin-dependent Diabetes Mellitus
Authors: Giatgen A Spinas, Andreas Bock, Ulrich Keller
Journal: Diabetes Care (1985)

The effect of a new octapeptide analogue of somatostatin (SMS 201-995) on blood glucose and gut hormone levels was studied in 10 C-peptide-negative, insulin-dependent diabetic (IDDM) subjects. On separate days, either 50 or 100 μg SMS or placebo was s.c. injected simultaneously with an identical insulin dose 30 min before a mixed meal. Postprandial blood glucose decreased after 100 μg SMS s.c. within 30 min from 8.9 ± 0.7 to 7.8 ± 0.6 mmol/L (P &amp;lt; 0.001) and remained at similar levels during 180 min. In contrast, postprandial blood glucose concentration increased after placebo from 9.9 ± 0.8 to 13.8 ± 0.9 mmol/L (SMS versus placebo P &amp;lt; 0.001). Plasma glucagon decreased rapidly after SMS to the limit of detection (P &amp;lt; 0.001) and remained lowered during 180 min; in contrast, glucagon levels increased after the meal during the placebo study (SMS versus placebo P &amp;lt; 0.001). Plasma growth hormone concentrations were significantly lower after SMS than after placebo (P &amp;lt; 0.05). SMS abolished completely the postprandial increase in plasma gastrin and pancreatic polypeptide (PP) concentrations. Plasma free fatty acid (FFA) and triglyceride concentrations decreased after SMS, reaching significantly lower levels than after placebo (P &amp;lt; 0.05 and P &amp;lt; 0.01), respectively). Plasma SMS concentration increased rapidly after s.c. administration of SMS; its appearance preceded that of plasma free insulin after s.c. insulin injection. Fifty micrograms SMS was similarly effective as 100 μg in decreasing blood glucose, triglycerides, glucagon, and gut hormone concentrations. The data demonstrate that in contrast to native somatostatin whose action is known to be relatively weak and shortlived after s.c. administration, this somatostatin analogue results in diminished postprandial blood glucose and plasma triglyceride concentrations and in prolonged suppression of gut hormone levels after s.c. injection.
Effects of a Clinical Trial on Mechanical Ventilation Practices in Patients with Acute Lung Injury
Authors: William Checkley, Roy Brower, Anna Korpak, B. Taylor Thompson
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

In a clinical trial by the Acute Respiratory Distress Syndrome Network (ARDSNet), mechanical ventilation with tidal volumes of 6 ml/kg decreased mortality from acute lung injury. However, interpretations of these results generated controversy and it was unclear if this trial would change usual-care practices.
THE SUSCEPTIBILITY OF THE HAMSTER TO MOUSE ENCEPHALOMYELITIS VIRUS
Authors: Donald J. Dean, Gilbert Dalldorf
Journal: The Journal of Experimental Medicine (1948)

The OT strain of mouse encephalomyelitis virus induces an inapparent infection in suckling hamsters associated with lesions of the central nervous system and skeletal muscles. The virus increases in pathogenicity after alternating mouse-hamster transfers and then induces both paralysis and encephalitis. Pathogenicity is lost through serial hamster passages but is restored by a single mouse transfer.
Environmental Tobacco Smoke and Heart Disease
Authors: Peter N Lee
Journal: JAMA (1992)

To the Editor.  —Dr Steenland 1 estimates more than 35000 deaths from ischemic heart disease occur annually in the United States from exposure to environmental tobacco smoke (ETS), a number similar to previous estimates by Wells 2 and Glantz and Parmley. 3 These estimates conflict with overviews of the evidence prepared under the auspices of a number of national authorities, none of which considered a causal relationship demonstrated. 4 The estimates take the epidemiological evidence essentially at face value, making adjustments only for a limited number of sources of bias, and failing to reflect the fragility of the data.  Steenland does not even mention publication bias, although a number of prospective studies presented data on lung cancer but not on heart disease. Nor does he mention the general paucity of available data. Only three studies 5-7 with more than 120 cases have been published despite the relatively high incidence of
Death from occupational disease.
Authors: D Slater, L Harvey
Journal: BMJ (1993)

Are undervaluedEDrroR,-Locum doctors have been strongly criticised since the General Medical Council found Dr Behrooz Irani guilty of serious professional misconduct.' Various suggestions have been put forward, including log books and registers to be stamped for all locums.23Why was it not suggested that every consultant in a substantive post should be supervised when prescribing potentially lethal drugs in response to the case of Dr Cox?4 A number of doctors in substantive posts have been stripped of their registration with the General Medical Council because of negligence.Then why not keep log books for all doctors in substantive posts?Most locums are good doctors-some are more efficient than regular doctors-and some are bad,
The Value of Cardiovascular Autonomic Function Tests: 10 Years Experience in Diabetes
Authors: David J Ewing, Christopher N Martyn, Robert J Young, Basil F Clarke
Journal: Diabetes Care (1985)

Five simple, noninvasive cardiovascular reflex tests have been used to assess autonomic function in one center over the past 10 yr. Seven hundred seventy-four diabetic subjects were tested for diagnostic and research purposes. In 543 subjects completing all five tests, abnormalities of heart rate tests occurred in 40%, while abnormal blood pressure tests occurred in less than 20%. Their results were grouped as normal (39%), early (15%), definite (18%), and severe (22%) involvement. Six percent had an atypical pattern of results. Two hundred thirty-seven diabetic subjects had the tests repeated greater than or equal to 3 mo apart: 26% worsened, 71% were unchanged, and only 3% improved. The worsening followed a sequential pattern with first heart rate and later additional blood pressure abnormalities. Comparison between a single test (heart rate response to deep breathing) and the full battery in 360 subjects showed that one test alone does not distinguish the degree or severity of autonomic damage. These tests provide a useful framework to assess autonomic neuropathy simply, quickly, and noninvasively.
ARTERIAL STIFFNESS IS ASSOCIATED WITH LIMITED LEFT VENTRICULAR STRETCH MOTION DURING EARLY DIASTOLIC PHASE IN NEVER TREATED, NON-COMPLICATED HYPERTENSION
Authors: Kyu Young Choi, Eun Joo Cho, Beom June Kwon, Dong Bin Kim, Seong Won Jang, Jae Hyung Kim
Journal: Journal of the American College of Cardiology (2011)
Clinical Pediatric and Adolescent Endocrinology
Authors: Barry H. Rich
Journal: JAMA (1983)

Dr Kaplan undertakes a difficult task, producing a new textbook of pediatric endocrinology. The need is real. The second edition of the benchmark work by Lawson Wilkins appeared in 1957. The goals of the two books are similar. Like Wilkins, Kaplan writes for the clinician, "to provide a practical reference source for knowledge regarding endocrine disorders affecting infants, children, and adolescents." Wilkins complains of the burden the advances of the six years between editions placed on him to present concisely the current state of the art. Now, a full generation later, 19 coauthors sift and sort. The result is not a "how-to" book and is most dissimilar to the recent handbooks or practical guides to pediatric endocrinology. The latter popular works, often found protruding from the house officer's coat pocket, provide tables of differential diagnosis, details to perform special diagnostic tests precisely, and normal ranges for obscure laboratory tests. This
Behcet's disease with decreased fibrinolysis and superior vena caval occlusion.
Authors: T Chajek, M Fainaru
Journal: BMJ (1973)

To determine germination rate and final germination percentage of the endangered Florida endemic Caribbean applecactus (<i>Harrisia fragrans</i> Small [Cactaceae]), we treated seeds with sulfuric and gibberellic (GA<sub>3</sub>) acids and germinated them under constant temperature regimes. Temperature effect was marginal at best, with only 2% of seed germinating in 50 d in 25 °C. Although there was improved germination with sulfuric acid (H<sub>2</sub>SO<sub>4</sub>) alone, significant increases in both germination rate and germination percentage were realized when seeds were scarified with 18 M H<sub>2</sub>SO<sub>4</sub> for 15,30,and 45 s,followed by soaking in 1000 ppm GA<sub>3</sub> for 24 h,with 68% germination in 120 d for the 45 s H<sub>2</sub>SO<sub>4</sub> treatment. Emergence first occurred on day 18 for seed treated with 1000 ppm GA<sub>3</sub> but not until day 70 for the 500 ppm treatment. Control seeds failed to emerge during the observation period. These treatments represent a quick method of meeting Species Level Recovery Actions for <i>Harrisia fragrans</i> in the Multi-Species Recovery Plans for South Florida.
Benzodiazepines may be linked to Alzheimer's disease, study finds
Authors: Z. Kmietowicz
Journal: BMJ (2014)

Taking benzodiazepines is associated with an increased risk of developing Alzheimer’s disease, particularly in long term users, a study has found.

Benzodiazepine use has long been associated with an increased risk of Alzheimer’s disease, although whether this association is causal remains unclear. To try to better understand the association, a team of researchers from France and Canada used data from the Quebec health insurance programme database (RAMQ) to track the development of Alzheimer’s in a sample of elderly residents living in Quebec, Canada, who had been prescribed benzodiazepines.1

Over a period of at least six years they identified 1796 cases of Alzheimer’s disease. They then compared these cases …
Dye bias correction in dual-labeled cDNA microarray gene expression measurements.
Authors: Barry A Rosenzweig, P Scott Pine, Olen E Domon, Suzanne M Morris, James J Chen, Frank D Sistare
Journal: Environmental Health Perspectives (2004)

A significant limitation to the analytical accuracy and precision of dual-labeled spotted cDNA microarrays is the signal error due to dye bias. Transcript-dependent dye bias may be due to gene-specific differences of incorporation of two distinctly different chemical dyes and the resultant differential hybridization efficiencies of these two chemically different targets for the same probe. Several approaches were used to assess and minimize the effects of dye bias on fluorescent hybridization signals and maximize the experimental design efficiency of a cell culture experiment. Dye bias was measured at the individual transcript level within each batch of simultaneously processed arrays by replicate dual-labeled split-control sample hybridizations and accounted for a significant component of fluorescent signal differences. This transcript-dependent dye bias alone could introduce unacceptably high numbers of both false-positive and false-negative signals. We found that within a given set of concurrently processed hybridizations, the bias is remarkably consistent and therefore measurable and correctable. The additional microarrays and reagents required for paired technical replicate dye-swap corrections commonly performed to control for dye bias could be costly to end users. Incorporating split-control microarrays within a set of concurrently processed hybridizations to specifically measure dye bias can eliminate the need for technical dye swap replicates and reduce microarray and reagent costs while maintaining experimental accuracy and technical precision. These data support a practical and more efficient experimental design to measure and mathematically correct for dye bias.
Law and General Practice
Authors: J. Cohen
Journal: BMJ (1995)

Chris Hughes Publishing Initiatives, £19.95, pp 101 ISBN 1 873839 09 X

All doctors are facing a big increase in the number of grumbles and complaints that they receive, both verbally and in writing.

These arise from changes in the values held by society, and the changing role and position of doctors. No longer are we all-knowing and benevolent--we are trained professionals with hearts, minds, emotions, and needs of our own, which sometimes conflict with the needs of our patients.

We work within bureaucratic structures that may put up barriers to our clinical free-dom, and make us choose between competing demands. Then there …
Plantar Warts and Athlete's Foot
Authors: A. A. Ross
Journal: BMJ (1964)

lower incidence of cervical carcinoma prob- ably was related to the universal practice of male circumcision amongst the Muslim com- munity.That male circumcision is unlikely to be the only factor involved in reducing cervical carcinoma is evident from the con- flicting literature on the subject.As Elliott3 points out, " No more can be said for the argument than that it is a hypothesis which fits the facts."As such it deserves consideration.-I am, etc.,
ACE Inhibition in Acute Myocardial Infarction
Authors: Marc A. Pfeffer
Journal: New England Journal of Medicine (1995)

Any new therapeutic advance requires clear proof of effectiveness from well-designed and well-conducted clinical trials that establish both the range of anticipated benefits and the potential adverse effects. However, for the results of clinical trials to be translated into clinical practice, physicians must be comfortable with their decisions to initiate and continue a new therapy in individual cases. Unlike clinical investigators, whose use of a new therapy is sheltered by protocol-based inclusion and exclusion criteria, titration regimens, and data and safety monitoring committees, the actions of treating physicians are more exposed. The assessment of whether a specific therapy will help . . .