tbuckley/cabot-search huggingface dataset:
Abstract 902: Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer
Authors: Karen S. Anderson, Jessica Wong, Gypsyamber D'Souza, Angelika B. Riemer, Jochen Lorch, Robert Haddad, Sarah Pai, Janina Longtine, Janine Bryan, Michael McClean, Joshua Labaer, Karl Kelsey, Marshall R. Posner
Journal: Cancer Research (2011)

Abstract Purpose: Human papillomavirus (HPV) type 16 is associated with oropharyngeal carcinomas (OPC). Antibodies (Abs) to HPV16 E6 and E7 oncoproteins have been detected in patient sera, however Abs to other early HPV-derived proteins have not been well explored. Experimental Design: Abs to the HPV16 proteome were quantified using a novel multiplexed bead assay, using C-terminal GST fusion proteins captured onto Luminex beads. Sera were obtained from two cohorts of untreated OPC patients with known Abs to HPV16 Virus-Like Particles (VLP) (N=10), HPV18 VLP (N=10), healthy controls (N=20), and from a validation cohort of untreated patients with OPC (N=30), partners of patients with HPV16+ OPC (N=11), and healthy controls (N=30). Results: OPC patients in the known VLP+ cohort had elevated serum Abs to HPV16 E1, E2, E4, E6, and E7, and L1 antibody levels but not E5. The ratios of specific median fluorescent intensity (MFI) to p21-GST compared to controls were: E1 50.7 vs. 2.1; E4 14.6 vs. 1.3; E6 11.3 vs. 2.4; E7 43.1 vs. 2.6; and L1 10.3 vs. 2.6 (each p&amp;lt;0.01). No cross-reactivity was detected between HPV16 E7 and HPV18 E7 Abs. In the validation cohort, HPV16 E1, E2, and E7 antibody levels were most significantly elevated compared to healthy control samples (p&amp;lt;0.0001) and partners of OPC patients (p&amp;lt;0.01). Conclusion: A novel multiplexed bead assay for the detection of HPV16-specific Abs demonstrates that patients with HPV16+ OPC have detectable Abs to multiple early genes, in particular E1, E2 and E7. These Abs are potential biomarkers for HPV-associated OPC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 902. doi:10.1158/1538-7445.AM2011-902
ADOLESCENT MALADJUSTMENT AND FAMILY DYNAMICS
Authors: ALBERTO C. SERRANO, EUGENE C. MCDANALD, HAROLD A. GOOLISHIAN, ROBERT MACGREGOR, AGNES M. RITCHIE
Journal: American Journal of Psychiatry (1962)

The various types of adolescent disorder may be related to 4 types of unhealthy family interaction. The adolescent's primary role in intrafamilial imbalance is to function as a stabilizing factor, that is, he internalizes or externalizes the unresolved, unspoken parental conflicts. The realization of his individual potentials and emotional growth are impaired, inasmuch as they are made secondary to the primary role. The neurotic equilibrium of the family broken when the adolescent's behavior becomes unendurable to himself, the family and/or society. This precipitates a crisis that tends to mobilize the family to seek some type of help. It is at this time that a clear understanding of adolescent maladjustment and family dynamics becomes most important for diagnostic and therapeutic purposes(11).
UNUSUAL REACTION TO INTRAPLEURAL ADMINISTRATION OF STREPTOKINASE AND STREPTODORNASE
Authors: George L. Baum
Journal: JAMA (1952)

Streptococcic fibrinolysin (streptokinase) and streptococcic desoxyribonuclease (streptodornase) have been found to be beneficial in treating a variety of clinical states. Their mode of action and therapeutic usefulness have been described elsewhere.<sup>1</sup>These enzymes have been chiefly employed in the liquefaction of pleural exudates. Toxic systemic reactions caused by these substrates have been reported.<sup>2</sup>In at least 50% of the patients treated there is a febrile reaction, with associated malaise, headache, orthopnea, and, occasionally, nausea. This generally occurs approximately four to six hours after the administration of streptokinase and streptodornase, subsiding in the ensuing 24 to 48 hours. According to the protocol furnished by the manufacturers of the drugs, these side-effects are treated symptomatically and rarely are of a nature requiring cessation of treatment. It is the purpose of this report to show that the thermal reaction may be attained by serious consequences and that the patient should be
Structural Variants of Prolactin: Occurrence and Physiological Significance
Authors: Y. N. SINHA
Journal: Endocrine Reviews (1995)

PROLACTIN (PRL) is one of the most versatile hormones of the pituitary gland in terms of biological actions. More than 100 different and distinct effects of the hormone have been documented (1), ranging from mammary development and initiation of lactation in mammals to osmoregulation in fishes, nesting behavior in birds, and growth and metamorphosis in amphibians. These are far in excess of the reported actions of all other adenohypophyseal hormones combined. But how does a single molecule evoke so many different responses? Studies in the last few years have shown that the hormone exists in several molecular forms, some arising from posttranslational modifications and others from genetically determined factors. Such findings have led to the suggestion that PRL is perhaps a prohormone, which is synthesized as a precursor molecule and then converted to different bioactive forms as it traverses the secretory pathway. The purpose of this review is to provide an account of the recent advances in the characterization of the molecular heterogeneity of PRL and to consider the physiological implications of the structural polymorphism of this polyfunctional hormone. Previous reviews of the subject can be found in Refs. 2–9.
Abstract B28: Autotaxin, LPA1 and LPA5 receptors in the tumor microenvironment determine melanoma invasion and metastasis
Authors: Sue-Chin Lee, Yuko Fujiwara, Jianxiong Liu, Junming Yue, Ryoko Tsukahara, Erzsebet Szabo, Renukadevi Patil, Duane D. Miller, Louisa Balazs, Tamas Oravecz, Gabor J. Tigyi
Journal: Cancer Research (2015)

Abstract Autotaxin (ATX), a lysophospholipase D that generates the growth factor-like mediator lysophosphatidic acid LPA, is up-regulated in metastatic and chemotherapy-resistant carcinomas. Many cancer cells secrete ATX, and it contributes to their invasive properties. The biological functions of ATX are mediated by LPA acting on G protein-coupled receptors (LPAR1-8). Many cancers overexpress multiple subtypes of LPAR and the overexpression of LPAR leads to malignant transformation, metastasis, and resistance to therapy. We have previously shown that knockdown of ATX expression in B16F10 melanoma cells decreased tumor invasion in vitro and lung metastasis in vivo. In our present study, we sought to understand the roles of LPAR both in the tumor cells and stromal cells of the tumor microenvironment. B16F10 melanoma cells predominantly express the LPA5 receptor. We found that these cells do not invade across a matrigel layer in response to LPA. shRNA knockdown of LPA5 receptors in B16F10 attenuates this inhibition, suggesting that the LPA5 receptor acts as an anti-invasive receptor in these tumor cells. Interestingly, we identified a different role for host LPA5 receptor. We found that the incidence of B16F10 lung metastasis was significantly reduced in the LPA5 knockout mice compared to wild type mice. In addition, LPA1 knockout mice also showed diminished B16F10 lung metastasis suggesting that host LPA1 and LPA5 receptors play critical roles in the seeding of metastasis. The decrease in tumor cell residence in the lungs of these knockout animals was apparent at 24 hours after injection. However, deletion of LPA1 or LPA5 did not affect the subcutaneous growth of B16F10 tumors. In summary, our results suggest that LPAR, in particular LPA5 and LPA1 receptors in tumor and stromal cells may play different roles in invasion and the seeding of metastasis. Citation Format: Sue-Chin Lee, Yuko Fujiwara, Jianxiong Liu, Junming Yue, Ryoko Tsukahara, Erzsebet Szabo, Renukadevi Patil, Duane D. Miller, Louisa Balazs, Tamas Oravecz, Gabor J. Tigyi. Autotaxin, LPA1 and LPA5 receptors in the tumor microenvironment determine melanoma invasion and metastasis. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr B28. doi:10.1158/1538-7445.CHTME14-B28
CARBON TETRACHLORIDE AS AN INDUSTRIAL HAZARD
Authors: PAUL A. DAVIS
Journal: JAMA (1934)

Carbon tetrachloride has many uses at the present time. Many years go it was tried as an anesthetic in place of chloroform but it was too toxic because of the high chlorine content. More recently it has been given as a remedy in hookworm and other intestinal parasitic diseases. It is at the present day used by the veterinary profession in treatment of canines. Perhaps the most frequent commercial uses of carbon tetrachloride today are the following: As a solvent in the rubber industry. As a cleansing agent in the dry cleaning industry. As a solvent in the chemical and drug industry. As an occluding and nonoxidizing agent in fire extinguishers. As a solvent in the paint industry. As an anthelmintic for parasites in the practice of medicine. In machine shops for the removal of grease in combination with benzine in order to
Development of an adenovirus vector lacking the expression of virus-associated RNAs
Authors: Mitsuhiro Machitani, Kazufumi Katayama, Fuminori Sakurai, Hayato Matsui, Tomoko Yamaguchi, Takayuki Suzuki, Hiroyuki Miyoshi, Kenji Kawabata, Hiroyuki Mizuguchi
Journal: Journal of Controlled Release (2011)
Catecholamine modulation of prefrontal cortical cognitive function
Authors: Amy F.T Arnsten
Journal: Trends in Cognitive Sciences (1998)

The prefrontal cortex (PFC) utilizes working memory to guide behavior and to release the organism from dependence on environmental cues and is commonly disrupted in neuropsychiatric disorders, normal aging, or exposure to uncontrollable stress. This review posits that the PFC is very sensitive to changes in the neuromodulatory inputs it receives from norepinephrine (NE) and dopamine (DA) systems and that this sensitivity can lead to marked changes in the working-memory functions of the PFC. While NE and DA have important beneficial influences on processing in this area, very high levels of catecholamine release, for example, during exposure to uncontrollable stress, disrupt the cognitive functions of the PFC. This fresh understanding of the neurochemical influences on PFC function has led to new treatments for cognitive disorders such as Attention Deficit Hyperactivity Disorder (ADHD), and may help to elucidate the prevalence of PFC dysfunction in other mental disorders.
Poliomyelitis — A Persistent Problem
Authors: Louis Weinstein
Journal: New England Journal of Medicine (1973)

The October 21 and October 28, 1972, issues of Morbidity and Mortality Weekly Report1,2 (Center for Disease Control, United States Public Health Service) featured a startling news item: an epidemic of poliomyelitis in a community in the United States. The area involved was not a socially, economically and medically deprived community but rather a private school in Greenwich, Connecticut, an affluent city most of whose residents are white and corporate executives, professionals and white-collar workers. Between September 29 and October 17, 1972, in nine male students between the ages of 12 and 18 years, and in two females, seven and . . .
Migratory properties and functional capacities of human skin dendritic cells
Authors: C.D. RICHTERS, M.J. HOEKSTRA, J. BAARE, J.S. PONT, E.C.M. HOEFSMIT, E.W.A. KAMPERDIJK
Journal: British Journal of Dermatology (2006)

The different cell types which migrated 'spontaneously’out of human skin explants during different periods of culture were characterized. Before culture, C'Dla + dendritic cells were observed not only in the epidermis but also in the dermis, whereas CDlb+ dendritic cells were present exclusively in the dermis. The populations of migrating cells were harvested and phenotyped on 3 successive days of culture. They always contained high percentages of CDla+ cells. The other cells that migrated were T cells and macrophages. A relatively high proportion of the CUla+ cells that migrated during the first 24 h culture period was also CDlb+. The number of cells which were positive for both CDla and CDlb decreased in the following 2 days of culture. However, the purified CUla+ cell populations isolated on the 3 consecutive days did not show any difference in their capacity to stimulate allogeneic T cells. The CDla+ cells possess potent allo‐activating capacities that are independent of whether or not they are positive for CDlb+. Three days after culture about half of the CDla+ cells were still present in the epidermis and dermis, but no CDlb+ cells could be detected in the dermis. This suggests that the CDlb+ cells represent a population of active migrating cells.
An overview of current efforts in short-term carcinogen testing.
Authors: H A Milman, P M Hurley, A Auletta
Journal: Environmental Health Perspectives (1983)

Scientists in the Health and Environmental Review Division (HERD), Office of Toxic Substances of the U.S. Environmental Protection Agency, are examining the feasibility of expanding efforts in short-term carcinogen testing. Three areas for consideration have been defined. These are (1) short-term in vitro tests; (2) short-term in vivo tests; and (3) tumor markers. HERD's current efforts in short-term in vitro testing are exemplified by the Gene-Tox program. Through a comprehensive system of committees and reviews, the published literature on eukaryotic and prokaryotic in vitro and in vivo test systems are being examined and analyzed. The suitability of utilizing the various systems in a test battery to identify potential chemical mutagens and carcinogens will be ascertained. A review of the literature on short-term in vivo tests (limited bioassays) and tumor markers is currently being conducted. Correlations will be made between results obtained from these tests and epidemiological information and long-term animal bioassays. The attributes and deficiencies of each test or marker will be examined. Further testing, development, or validation needs will be outlined. The aim of this review is to attempt to expand the prechronic test battery for carcinogenicity in order to provide sufficient information for regulatory decision-making.
Health Effects of Exposure to Natural Arsenic in Groundwater and Coal in China: An Overview of Occurrence
Authors: Guangqian Yu, Dianjun Sun, Yan Zheng
Journal: Environmental Health Perspectives (2007)

Between 2001 and 2005, 21,155 of 445,638 wells in 20,517 villages in 292 counties in 16 provinces from China, or 5% of wells, were found to contain > 50 microg/L arsenic (As) by field testing with the Merck As kit. We achieved quality assurance of analysis of at least 10% of the wells containing > 50 microg/L As using hydride generation atomic fluorescence spectrometry and silver dithiodicarbomate spectrometry. Our best estimate of the population exposed to > 50 microg/L As in drinking water was 582,769. This is probably an underestimate for China because of the limited area surveyed. In a survey of 135,492 individuals in eight provinces, we used the National Diagnosis Standard for Endemic Arsenicosis and identified 10,096 cases of arsenicosis with various degrees of skin lesions. The arsenicosis occurrence rate of 7.5% is likely an overestimate, because the survey focused more on known and suspected endemic areas of arsenicosis. The occurrence of arsenicosis correlates positively with the percentage of wells containing > 50 microg/L As, or at a ratio of 1 to 5%. Based on both the amount of As in well water and the rate of occurrence of arsenicosis, Shanxi province, Inner Mongolia autonomous region, and Jilin province are the top three areas in China as of 2005 for exposure to endemic As from drinking water. Our survey also identified exposure to high levels of As from wells in several provinces and from the indoor burning of coal containing high levels of As in Shaanxi province. These areas, however, have not had any reports of previous arsenicosis endemics. In the endemic areas, the average rate of occurrence of arsenicosis at advanced stages was 1.2%, possibly because of a long exposure time of > 20 years; the rate of occurrence increased to 2.7% when we included a high dose of As exposure from the indoor burning of coal. Mitigation to reduce As exposure remains a challenge in rural China.
Restoration of dysregulated CC chemokine signaling for monocyte/macrophage chemotaxis in head and neck squamous cell carcinoma patients by neem leaf glycoprotein maximizes tumor cell cytotoxicity
Authors: Krishnendu Chakraborty, Anamika Bose, Tathagata Chakraborty, Koustav Sarkar, Shyamal Goswami, Smarajit Pal, Rathindranath Baral
Journal: Cellular and Molecular Immunology (2010)
Cancer Pain: Psychological Management Using Hypnosis
Authors: J. Barber, J. Gitelson
Journal: CA A Cancer Journal for Clinicians (1980)

In the treatment of cancer, particularly when pain is a serious symptom, psychological support of a patient is important and can, in fact, facilitate ongoing oncologic treatment. Hypnosis represents a psychological technique of great potency for reducing pain, increasing patients' life-enhancing attitudes, and helping patients deal with death and separation. Ultimately, the value of hypnosis lies in enabling an individual to potentiate inner capacities for creating psychological quiescence and physical comfort. For a suffering cancer patient, relief that comes from within can provide a much-needed experience of personal efficacy and strength.
Chemotherapy for gastric cancer by finely tailoring anti-Her2 anchored dual targeting immunomicelles
Authors: Wei Li, He Zhao, Weizhu Qian, Huafei Li, Li Zhang, Zengwei Ye, Ge Zhang, Mao Xia, Jinfeng Li, Jie Gao, Bohua Li, Geng Kou, Jianxin Dai, Hao Wang, Yajun Guo
Journal: Biomaterials (2012)
Digestive Diseases and the Teeth
Authors: WILLIAM LINTZ
Journal: Annals of Internal Medicine (1931)

Article1 March 1931Digestive Diseases and the TeethWILLIAM LINTZ, M. D.WILLIAM LINTZ, M. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-9-1188 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a personal communication, Dr. C. H. Mayo makes a statement that "75% of human ailments come from what goes into the mouth including food and drink, and the diseases of the mouth which cause local and general disease, and focal infections which may remain a cause of disease over a long period of time." From this statement it is at once apparent how important is a study of the teeth in disease in general and in digestive diseases in particular.CASES FOR INVESTIGATIONOut of 361 consecutive office patients (See Table III) suffering with the various ailments for which...Bibliography1 LINTZ W American Journal Medical Science, May 1927, p. 682. Cholecystography and Lyon-Meltzer Test in a Patient with a Congenitally Absent Gall-Bladder. CrossrefGoogle Scholar2 LINTZ W: Dental Outlook, 1925, vol. xii, p. 267. Necessity for Inter-Relationship Between Physician and Dentist. Google Scholar3 LINTZ W: N. Y. State Journal Medicine, March 6, 1925. Appendicitis in 300 cases of Asthma and Other Forms of Allergy. Google Scholar4 BARCLAYMACWILIAMS HCA: New York State Journal Medicine Vol. XXI, p. 39. Remarks on the Diagnosis of Right Iliac Fossae Pains and the End Results in 200 Chronic Appendicitis Operations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClinical Oral Pathology as Related to Oral Diagnosis 1 March 1931Volume 4, Issue 9Page: 1188-1196KeywordsFoodInfectious diseasesMouth Issue Published: 1 March 1931 PDF DownloadLoading ...
796 USE OF EXOGENOUS INSULIN OR SULFONYLUREA ASSOCIATED WITH AN INCREASED INCIDENCE OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH HEPATITIS C VIRUS INFECTION
Authors: T. Kawaguchi, E. Taniguchi, Y. Morita, M. Shirachi, Y. Tateishi, E. Nagata, M. Sata
Journal: Journal of Hepatology (2009)
NARCOLEPSY IN THE PICKWICKIAN SENSE
Authors: Phillip E. Rothman
Journal: JAMA (1933)

To the Editor:  —The portrayal of the symptoms of a disease in a fictional character is always interesting reading. This is particularly true if the novel appeared before the malady was studied systematically or recorded authoritatively in the medical literature. An example of this kind occurs in Charles Dickens's Pickwick Papers. In a humorous character sketch, Dickens portrayed the symptoms of narcolepsy forty years before the publication of its first description as a clinical entity.  This disease, which physicians find fascinating because of its rarity and extraordinary manifestations, was described in 1877 by Westphal. He has properly received the credit attached to priority, although it was not until three years later that Gelineau first applied the term narcolepsy as a name for brief and sudden attacks of irresistible sleep. One of his patients had some two hundred attacks a day, each lasting from one to five minutes. Sir William Gowers
Super Cells—Metabolic and Functional Behavior of Red Cells with Extreme Elevation of 2,3-Diphosphoglycerate.
Authors: A. S. Keitt
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Super Cells—Metabolic and Functional Behavior of Red Cells with Extreme Elevation of 2,3-Diphosphoglycerate.A. S. Keitt, M.D., J. M. Salhany, R. S. Eliot, M.D., F.A.C.P.A. S. Keitt, M.D.Search for more papers by this author, J. M. SalhanySearch for more papers by this author, R. S. Eliot, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-827_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt2,3-Diphosphoglycerate (DPG) is known to influence the oxygen equilibrium of hemoglobin and has been thought to participate in the regulation of glycolysis and nucleotide catabolism by inhibiting certain red cell enzymes. To examine further these properties of DPG in the intact red cell, fresh cells (hematocrit, 10%) were incubated with inosine, pyruvate, and phosphate (IPP), 20 mMeach, for 16 hr at 37 C so as to increase their content of DPG. The glycolytic metabolism of these cells was examined during prolonged incubation after removal of IPP (Method: Keitt,J Clin Invest48:1997, 1969). Hemoglobin function was estimated by determining... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Gainesville, Fla. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe rate of deoxygenation of red blood cells: Effect of intracellular 2,3-diphosphoglycerate and pH 1 May 1971Volume 74, Issue 5Page: 827-827KeywordsBehaviorCatabolismCell metabolismCellsEnzymesHematocritHemoglobinOxygenPhosphatesPyruvate Issue Published: 1 May 1971 PDF DownloadLoading ...
UNIFORMITY THE KEY TO RECIPROCITY.
Authors: WILLIAM WARREN POTTER
Journal: JAMA (1898)

behind other branches of science in taking advantage of improved methods of research and in establishing itself upon the sound basis of faots, demonstrated by experiment and observation with instruments of precision.What has been said will also show that there is no room for creeds and pathies in medicine, any more than in astronomy, geology or botany.Every man is