tbuckley/cabot-search huggingface dataset:
Trial of support treatment with human chorionic gonadotrophin in the luteal phase after treatment with buserelin and human menopausal gonadotrophin in women taking part in an in vitro fertilisation programme.
Authors: E. M. Smith, F. W. Anthony, S. C. Gadd, G. M. Masson
Journal: BMJ (1989)

To evaluate the effect of support with human chorionic gonadotrophin in the luteal phase in women taking part in an in vitro fertilisation programme after buserelin and human menopausal gonadotrophin were used to hyperstimulate their ovaries.Controlled group comparison.Outpatient department of a private hospital.115 Women with indications for in vitro fertilisation, all of whom had at least one embryo transferred.After suppression of the pituitary with buserelin the ovaries of all the women were stimulated with human menopausal gonadotrophin on day 4 of the luteal phase. Human chorionic gonadotrophin (10,000 IU) was given to induce ovulation, and oocytes were recovered 34 hours later. Embryos were transferred 46 to 48 hours after insemination. Women who had received the 10,000 IU of human chorionic gonadotrophin on a date that was an uneven number (n = 61) were allocated to receive support doses of 2500 IU human chorionic gonadotrophin three and six days after that date. The remaining 54 women did not receive hormonal support.Determination of the rates of pregnancy. MEASUREMENTS and main results--Support with human chorionic gonadotrophin did not significantly alter the progesterone or oestradiol concentrations in the early or mid-luteal phase. The mean (range) progesterone concentrations in the late luteal phase in women who did not become pregnant were, however, significantly higher in those who received support (16(9-110) nmol/l nu 8(4-46) nmol/l), and the luteal phase was significantly longer in this group (14 days nu 12 days). The rate of pregnancy was significantly higher in the women who received support than in those who did not (25/61 nu 8/54).When buserelin and human menopausal gonadotrophin are used to hyperstimulate ovaries support with human chorionic gonadotrophin in the luteal phase has a beneficial effect on in vitro fertilisation.
Management of the Pregnant Asthmatic Patient
Authors: Elaine S. Turner, Paul A. Greenberger, Roy Patterson
Journal: Annals of Internal Medicine (1980)

Asthma is not an uncommon medical problem during pregnancy. Various physiologic alterations of pregnancy may theoretically affect asthma. Fetal oxygenation is affected more by maternal alkalosis than by hypoxemia, both of which can occur during uncontrolled asthma. Clinical studies suggest a variable effect of pregnancy on asthma and increased maternal and fetal morbidity and mortality associated with severe asthma. Most antiasthmatic drugs are safe to use during pregnancy. Medications used during delivery by the obstetrician may affect asthma, and some antiasthmatic medications may alter labor. We review here a rational approach to the management of steroid preparation for delivery in steroiddependent asthmatic patients. Asthmatic mothers may breast-feed with minimal risk of adverse drug effects on the infant.
Conditioning of the diaphragm by phrenic nerve pacing in primary alveolar hypoventilation.
Authors: P G Wilcox, P D Pare, J A Fleetham
Journal: Thorax (1988)

The effect of beta-adrenoceptor antagonists on the respiratory response to carbon dioxide rebreathing was studied in eight normal subjects. Propranolol, atenolol, metoprolol, and placebo were given in random, double-blind fashion. Subjects were studied before each treatment period, after one dose, and after eight days of treatment with each drug. A rebreathing method was used to produce progressive hypercapnia and the respiratory response was assessed by measuring minute ventilation and maximum rate of change of inspiratory mouth pressure. Beta-blockade was assessed by the reduction in heart rate during steady state exercise on a cycle ergometer. There was no change in the respiratory response to carbon dioxide after a single dose or eight days treatment of any drug. All three active drugs produced a significant reduction in exercise heart rate. The forced expiratory volume in one second was not altered by any of the drugs.
Where Do Residency Graduates Start Medical Practice?-Reply
Authors: Rebecca S. Miller
Journal: JAMA (1997)

<h3>In Reply.</h3> —We agree with Dr Stolee that practicing in a community of any size should not be presented as undesirable as long as it is the physician's choice. Unfortunately, working in a small town does not appear to be the choice of an adequate number of physicians. Over the years, some workforce planners have argued to remedy the lack of physicians in small towns and underserved areas by overproducing the supply of physicians, thereby forcing location in these areas. Others, including us, disagree with this concept and believe that positive incentives are essential to increase the number of physicians in small towns. Stolee's approach of educating physicians interested in small town practice has achieved a laudable degree of success. In our survey, we asked how many physicians practiced in small towns (22.3%) and, of those physicians, how many found an employment opportunity only by doing so. The findings indicated that 3.4%
Nanoparticles and microparticles for skin drug delivery
Authors: Tarl W. Prow, Jeffrey E. Grice, Lynlee L. Lin, Rokhaya Faye, Margaret Butler, Wolfgang Becker, Elisabeth M.T. Wurm, Corinne Yoong, Thomas A. Robertson, H. Peter Soyer, Michael S. Roberts
Journal: Advanced Drug Delivery Reviews (2011)
Effects of staphylococci on cytokine production from human keratinocytes
Authors: T. Sasaki, R. Kano, H. Sato, Y. Nakamura, S. Watanabe, A. Hasegawa
Journal: British Journal of Dermatology (2003)

Staphylococcus skin infection is characterized by the infiltration of numerous neutrophils within the epidermis; however, the precise mechanism of epidermal infiltration of neutrophils during skin infection with staphylococci is not well understood and the factors regulating the neutrophil recruitment are yet to be determined.We investigated the effects of staphylococci on cytokine production from keratinocytes, specifically to elucidate the mechanisms of neutrophil infiltration within the epidermis in cutaneous microbial infection.Cytokine production from human keratinocytes was examined after stimulation with heat-killed Staphylococcus aureus, S. epidermidis and S. intermedius.Interleukin (IL)-6 and IL-8 were detected in the culture supernatants by enzyme-linked immunosorbent assay but IL-1beta, monocyte chemotactic protein-1 and tumour necrosis factor-alpha were not. IL-6 and IL-8 mRNAs were also confirmed by reverse transcription-polymerase chain reaction in the keratinocytes stimulated with killed staphylococci for 1, 3, 6, 10 and 24 h.These results could explain the epidermal infiltration of neutrophils in cutaneous infection with staphylococci, suggesting that the analysis of cytokines might add valuable information for the pathogenesis of cutaneous infection with Staphylococcus species.
STUDY OF TROPICAL DISEASES IN THE PHILIPPINE ISLANDS.
Authors: P. M. ASHBURN
Journal: JAMA (1907)

During the last quarter the following research work has been accomplished along special lines of investigation: <h3>A. DEVELOPMENT OF FILARIA PHILIPPINENSIS IN THE MOSQUITO.</h3> Although we have not yet completed our work on this parasite and are not prepared to make a full report on the subject, which we hope to do later, we have, nevertheless, devoted considerable study to the subject since our last report and have demonstrated the following facts: Filaria philippinensis undergoes a stage of development in the body of Culex fatigans. This mosquito, in drawing blood from the infected patient, manages in some way to get about 40, 50 or more times as many filariæ as are found in an equal amount of blood obtained by a needle puncture. A proportion of the mosquitoes thus infecting themselves seem to succumb to the infection; two of them that we have seen seem to have died acutely of
Whole-exome sequencing diagnosis of two autosomal recessive disorders in one family
Authors: T. Takeichi, A. Nanda, S. Aristodemou, J.R. McMillan, J. Lee, M. Akiyama, H. Al-Ajmi, M.A. Simpson, J.A. McGrath
Journal: British Journal of Dermatology (2014)

Autosomal recessive congenital ichthyosis (ARCI) is a genetically heterogeneous disorder for which subtyping through molecular analysis can help determine the eventual phenotype and prognosis. We used whole-exome sequencing to identify a new homozygous splice-site mutation in ST14 (IVS5+1G>A), encoding matriptase, in a 4-year-old girl with ARCI from a consanguineous Kuwaiti family. Clinically, she also had hypotrichosis, which supported a diagnosis of ARCI type 11. Only four previous examples of pathogenic mutations in ST14 have been reported, and our findings expand the genotype-phenotype correlation for this subtype of ARCI. Our patient was the second child born to these parents; the first (deceased) and third children had congenital brain and eye abnormalities, of uncertain aetiology and with no precise diagnosis. Further analysis of our patient's exome dataset revealed heterozygosity for a splice-site mutation in POMT1 (IVS4+1G>T), encoding the protein O-mannosyltransferase, a gene implicated in Walker-Warburg syndrome. DNA sequencing in the third child showed homozygosity for this mutation in POMT1. The first-cousin parents were both heterozygous for the splice-site mutations in ST14 and POMT1. In this family, whole-exome sequencing provided accurate subtyping of a form of ARCI in one child and provide an explanation for an undiagnosed developmental disorder in two other children, findings that improve the prospects for diagnostic accuracy and genetic counselling, and demonstrate the impact of next-generation sequencing technologies on clinical genetics.
Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle
Authors: Noriaki Shimizu, Noritada Yoshikawa, Naoki Ito, Takako Maruyama, Yuko Suzuki, Sin-ichi Takeda, Jun Nakae, Yusuke Tagata, Shinobu Nishitani, Kenji Takehana, Motoaki Sano, Keiichi Fukuda, Makoto Suematsu, Chikao Morimoto, Hirotoshi Tanaka
Journal: Cell Metabolism (2011)
Prognostic Model for Primary Melanoma
Authors: Bimal P. Jain
Journal: Annals of Internal Medicine (1997)

Letters15 May 1997Prognostic Model for Primary MelanomaBimal P. Jain, MDBimal P. Jain, MDUnion Hospital, Lynn, MA 01904Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-10-199705150-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The four-variable probability model developed by Schuchter and colleagues [1] for estimating prognosis of primary melanoma represents a clinically useful approach to a difficult problem. The model's accuracy can be increased considerably, I believe, by using it in a slightly different manner. I suggest that a probability of survival in a subgroup be used to estimate prognosis only if the entire CI and not just the point probability lie outside the intermediate probability range of 0.3 to 0.7. This would enable us to accurately estimate prognosis in 95% of 315 patients in 14 of the 32 subgroups ...References1. Schuchter L, Schultz DJ, Synnestvedt M, Trock BJ, Guerry D, Elder DE, et al. A prognostic model for predicting 10-year survival in patients with primary melanoma. Ann Intern Med. 1996; 125:369-75. Google Scholar2. Braitman LE, Davidoff F. Predicting clinical states in individual patients. Ann Intern Med. 1996; 125:406-12. Google Scholar Author, Article, and Disclosure InformationAuthors: Bimal P. Jain, MDAffiliations: Union Hospital, Lynn, MA 01904 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIdentification of a Gene-Related Risk Signature in Melanoma Patients Using Bioinformatic Profiling 15 May 1997Volume 126, Issue 10Page: 832KeywordsLymphocytesMelanoma ePublished: 15 August 2000 Issue Published: 15 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells
Authors: Erzsébet Zavaczki, Viktória Jeney, Anupam Agarwal, Abolfazl Zarjou, Melinda Oros, Mónika Katkó, Zsuzsa Varga, György Balla, József Balla
Journal: Kidney International (2011)

Osteoblastic differentiation of vascular smooth muscle cells (VSMCs) is involved in the pathogenesis of vascular calcification. Hydrogen sulfide (H<sub>2</sub>S) is a gas endogenously produced by cystathionine γ-lyase in VSMC. Here we determined whether H<sub>2</sub>S plays a role in phosphate-induced osteoblastic transformation and mineralization of VSMC. Hydrogen sulfide was found to inhibit calcium deposition in the extracellular matrix and to suppress the induction of the genes involved in osteoblastic transformation of VSMC: alkaline phosphatase, osteocalcin, and Cbfa1. Moreover, phosphate uptake and phosphate-triggered upregulation of the sodium-dependent phosphate cotransporter (Pit-1) were also prevented by H<sub>2</sub>S. Reduction of endogenous production of H<sub>2</sub>S by inhibition of cystathionine γ-lyase activity resulted in increased osteoblastic transformation and mineralization. Low plasma levels of H<sub>2</sub>S, associated with decreased cystathionine γ-lyase enzyme activity, were found in patients with chronic kidney disease receiving hemodialysis. Thus, H<sub>2</sub>S is a potent inhibitor of phosphate-induced calcification and osteoblastic differentiation of VSMC. This mechanism might contribute to accelerated vascular calcification in chronic kidney disease.
Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony-stimulating factor mRNA and protein. A potential autocrine role for interleukin 1 in epidermis.
Authors: T S Kupper, F Lee, N Birchall, S Clark, S Dower
Journal: Journal of Clinical Investigation (1988)

Cultured human keratinocytes have been shown to produce IL-1 alpha and beta mRNA and protein. IL-1 biological activity has been identified in normal human epidermis; in vitro, most biologically active IL-1 resides in a cell-associated compartment. The potential for autocrine effects of IL-1 on human keratinocytes was assessed by measurement of keratinocyte IL-1 receptors. Both high- and low-affinity cell surface receptors that bound recombinant (r) IL-1 alpha and beta with comparable affinities could be identified on cultured human keratinocytes, using 125I-labeled rIL-1. Chemical crosslinking experiments identified a cell surface molecule of roughly 72,500 Mr that bound 125I-labeled IL-1, similar to the molecular weight of previously described IL-1 receptors on fibroblasts, B cells, and T cells. To assess the biological consequences of keratinocyte IL-1 binding, granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression was measured. The addition of exogenous rIL-1 alpha led to a dose-dependent increase in the accumulation of GM-CSF mRNA, as measured by a sensitive and specific S1 nuclease assay. This increase in mRNA was reflected in a marked increase in GM-CSF biological activity as measured by proliferation of blast cells from chronic myelogenous leukemia patients. The biological activity was completely inhibitable by an antibody to human rGM-CSF. GM-CSF activates mature neutrophils and macrophages and appears to enhance the efficiency of Langerhans cell antigen presentation to T cells. Release of IL-1 from injured or activated keratinocytes may lead to enhanced epidermal GM-CSF gene expression via an autocrine mechanism, thus enhancing local host defense.
ETV6–FLT3 fusion gene-positive, eosinophilia-associated myeloproliferative neoplasm successfully treated with sorafenib and allogeneic stem cell transplant
Authors: L Falchi, M Mehrotra, K J Newberry, L M Lyle, G Lu, K P Patel, R Luthra, U Popat, S Verstovsek
Journal: Leukemia (2014)
Imaging of hepatitis C virus infection in liver grafts after liver transplantation
Authors: Laura Mensa, Sofía Pérez-del-Pulgar, Gonzalo Crespo, George Koutsoudakis, Carlos Fernández-Carrillo, Mairene Coto-Llerena, Rosa Miquel, Helena Allende, Lluís Castells, Miquel Navasa, Xavier Forns
Journal: Journal of Hepatology (2013)
Isolation in the Control of Dysentry
Authors: R. G. Hendrickse
Journal: BMJ (1973)

12 hours.His E.C.G. was monitored and he went into atrial fibrillation on a second occasion, reverting to sinus rhythm after six hours, again without treatment.His neurological condition showed steady improvement and he was dis- charged walking with sticks.The cause of his atrial fibrillation remains obscure though toxic myocarditis is a possibility.He had no obvious chest or other infec- tion nor evidence of ischaemic heart disease either clinically or on E.C.G.s taken before and after exertion."Paralysis of the heart" in neuropathy was described by Oslerl in 1892 and tachycardia was noted by Guillain,2 Kernohan,3 and others.Davies and Dingle4 described five patients with Guillain-Barrd syndrome, all on respirators, who had tachycardia, one of whom showed ventricular ectopic beats on the E.C.G.Of 15 recent cases seen in this hospital, eight had a pulse rate (between 120 and 160/min and half showed non-specific S-T changes in the E.C.G.This tachycardia was out of proportion to any expected rise asso- ciated with a pyrexia and tended to occur at the height of the illness.It may be that the mortality of around 10%5 seen in this condition despite effective positive pressure respiration may be in part due to cardiac arrhythmias, and on the pre- mise that these are potentially treatable E.C.G. monitoring of all patients showing a sustained tachycardia is advisable.I would like to thank Dr. P. Millac for per- mission to report this case and for helpful criticism.
Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis
Authors: Johannes Noe, Gerd A. Kullak-Ublick, Wolfram Jochum, Bruno Stieger, Reinhold Kerb, Michael Haberl, Beat Müllhaupt, Peter J. Meier, Christiane Pauli-Magnus
Journal: Journal of Hepatology (2005)
Infectivity-selective Oncolytic Adenovirus Developed by High-throughput Screening of Adenovirus-formatted Library
Authors: Yoshiaki Miura, Satoshi Yamasaki, Julia Davydova, Eric Brown, Kazunori Aoki, Selwyn Vickers, Masato Yamamoto
Journal: Molecular Therapy (2012)

Adenovirus (Ad) is a potent gene-delivery vehicle and has frequently been used for designing oncolytic viruses. However, lack of selectivity on infection has hampered the achievement of sufficient in vivo efficiency. Here, we developed a novel oncolytic virus system, infectivity-selective oncolytic adenovirus (ISOAd), via direct high-throughput screening of a high-diversity targeting-ligand library in adenoviral format. Through our newly designed rescue virus system, the high-diversity Ad library carrying the random seven amino acid sequences ligand-library in the AB-loop of its fiber-knob region (5 × 109 diversity) was successfully generated. During the screening of this library with the cells expressing the target molecule (mesothelin, MSLN), the AB-loop sequence of the virus clones converged to one dominant sequence and a novel MSLN-targeting sequence was isolated. The virus with the isolated motif showed selective infectivity to MSLN-positive cells in vitro. In vivo, it exhibited a selective and potent antitumor effect resulted from the viral replication in MSLN-positive xenografts. The ISOAd is a novel class of oncolytic Ad, which has selectivity at the step of transduction. The selectivity at the stage of infection can open new perspectives in oncolytic Ad therapy for various diseases. Adenovirus (Ad) is a potent gene-delivery vehicle and has frequently been used for designing oncolytic viruses. However, lack of selectivity on infection has hampered the achievement of sufficient in vivo efficiency. Here, we developed a novel oncolytic virus system, infectivity-selective oncolytic adenovirus (ISOAd), via direct high-throughput screening of a high-diversity targeting-ligand library in adenoviral format. Through our newly designed rescue virus system, the high-diversity Ad library carrying the random seven amino acid sequences ligand-library in the AB-loop of its fiber-knob region (5 × 109 diversity) was successfully generated. During the screening of this library with the cells expressing the target molecule (mesothelin, MSLN), the AB-loop sequence of the virus clones converged to one dominant sequence and a novel MSLN-targeting sequence was isolated. The virus with the isolated motif showed selective infectivity to MSLN-positive cells in vitro. In vivo, it exhibited a selective and potent antitumor effect resulted from the viral replication in MSLN-positive xenografts. The ISOAd is a novel class of oncolytic Ad, which has selectivity at the step of transduction. The selectivity at the stage of infection can open new perspectives in oncolytic Ad therapy for various diseases.
Role of immune complexes in rheumatoid polyarteritis.
Authors: J B Farrell, D A Person, R D Rossen, M D Lidsky
Journal: Annals of the Rheumatic Diseases (1979)

Serial clinical and serological observations were made on a patient with necrotising polyarteritis associated with rheumatoid arthritis. Significant levels of circulating immune complexes, as determined by a C1q binding assay, were observed up to 2 years before the clinical manifestations of polyarteritis but rose abrumptly immediately before and concurrently with the onset of polyarteritis. Concomitant serial determinations of C3, latex fixation titres for anti-immunoglobulin, and patterns of fluorescence of antinuclear antibody afforded insight into the nature of these somplexes, as did clinical and serological response to glucocorticoid and cytotoxic therapy. Our data suggest that the antibody involved in the complex was of the IgG class and capable of complement fixation.
Carotid Stenting at the Crossroads
Authors: Ethan A. Halm
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal