tbuckley/cabot-search huggingface dataset:
Surgical Treatment of Asymptomatic Carotid Stenosis
Authors: Henry J.M. Barnett
Journal: Annals of Internal Medicine (1996)

Letters15 September 1996Surgical Treatment of Asymptomatic Carotid StenosisHenry J.M. Barnett, MD, Michael Eliasziw, PhD, and Heather Meldrum, BAHenry J.M. Barnett, MDThe John P. Robarts Research Institute, London N6A 5K8, Ontario, CanadaSearch for more papers by this author, Michael Eliasziw, PhDThe John P. Robarts Research Institute, London N6A 5K8, Ontario, CanadaSearch for more papers by this author, and Heather Meldrum, BAThe John P. Robarts Research Institute, London N6A 5K8, Ontario, CanadaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-6-199609150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree completely that data from trial subgroups should be interpreted cautiously. Nevertheless, it is disappointing that the survival curves for the secondary analysis of disabling stroke remained superimposed for 4.5 years [1]. The lack of benefit for women could be due to small numbers rather than an absence of benefit. The perioperative complication rate of stroke in women (3.6%) was double that in men (1.7%).We did not imply that the ACAS was reporting 60% as an area stenosis. Our comment was that “60% is only equivalent to a linear measurement on an arteriogram if the cut-point ...References1. Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA. 1995; 273:1421-8. Google Scholar2. Barnett HJ, Meldrum HE, Eliasziw M. The dilemma of surgical treatment for patients with asymptomatic carotid disease. Ann Intern Med. 1995; 123:723-5. Google Scholar3. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med. 1991; 325:445-53. Google Scholar4. Eliasziw M, Smith RF, Singh N, Holdsworth DW, Fox AJ, Barnett HJ, et al. Further comments on the measurement of carotid stenosis from angiograms. Stroke. 1994; 25:2445-9. Google Scholar5. Halliday AW, Thomas D, Mansfield A, for the Steering Committee and for the collaborators. The Asymptomatic Carotid Surgery Trial (ACST): rationale and design. Eur J Vasc Surg. 1994; 8:703-10. Google Scholar Author, Article, and Disclosure InformationAffiliations: The John P. Robarts Research Institute, London N6A 5K8, Ontario, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1996Volume 125, Issue 6Page: 517KeywordsAbsolute risk reductionCarotid endarterectomyPatient Protection and Affordable Care ActRandomized trialsStenosisStrokeSurgeonsSurgerySurvival analysisUltrasound imaging Issue Published: 15 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Monitoring the success of articles: a look back and a look ahead
Authors: H. M. Piper, D. Garcia-Dorado, E. A. Martinson
Journal: Cardiovascular Research (2008)

The Editorial Team at Cardiovascular Research ( CVR ) is constantly trying to evaluate which research topics are the most interesting to its readers. Two ways we do this is to look at which articles are most often downloaded from the Journal's website on the Internet and which are cited most frequently in the literature. Now, at the end of 2008, we are in a position to look back at the year 2007 to see how well the papers from last year performed and which were most popular. In addition, this will give us a look ahead at our next impact factor for 2008.

Table 1 shows the 20 most-cited articles from 2007. It is not surprising that review articles were the most cited, with all of the top 10 being reviews. … 

*Corresponding author. Tel: +49 641 99 47242; fax: +49 641 99 47209. E-mail address : CVR{at}physiologie.med.uni-giessen.de
Paroxysmal Tachycardia
Authors: GEORGE O. BELL, ROBERT B. BRADLEY, LEWIS M. HURXTHAL
Journal: Circulation (1950)

An interesting case of recurrent paroxysmal tachycardia is presented. The patient had had a previous coronary thrombosis, leaving in its wake a residual left bundle branch block. Three episodes of paroxysmal tachycardia were observed, the longest one of sixty-three days' duration. Although ventricular origin of the tachycardia was thought to be most likely, a nodal origin was also considered. All forms of therapy were tried but only intravenous quinidine proved to be successful. Experiences with massive doses of quinidine intravenously are presented.
Influence of dietary fat on the effect of endotoxin on murine hepatic peroxisomes
Authors: J G DeLamatre, J T Schilleci, L H Hanson
Journal: Hepatology (1996)

This study investigates the effects of either a high-fat diet or endotoxin on peroxisome metabolism as assessed by measuring catalase activity, catalase mass, and peroxisomal beta-oxidation. Three mouse strains C3H/HeJ, BALB/c, and C57BL/6J were fed either a low-fat or a high-fat diet and injected intraperitoneally with 1 microg Escherichia coli lipopolysaccharide. These parameters were not different in C3H/HeJ mice fed a high-fat diet compared with controls fed a low-fat diet. Total liver catalase activity and peroxisomal beta-oxidation were higher in BALB/c mice fed high-fat diet compared with low-fat controls. Total liver catalase activity, catalase mass and peroxisomal beta-oxidation increased to the greatest extent in C57BL/6J mice fed a high-fat diet. Endotoxin treatment did not alter any of the parameters in mice fed a low-fat diet. Among mice fed a high-fat diet, endotoxin did not affect hepatic catalase or peroxisomal beta-oxidation in the C3H/HeJ mice, decreased catalase activity in BALB/c mice (28%), and greatly decreased both catalase (66%) and peroxisomal beta-oxidation (69%) in C57BL/6J mice. The decrease in catalase activity in C57BL/6J mice was apparently because of an inactivation of the enzyme as determined by the activity/mass ratio. Thus, endotoxin is showed to inhibit both catalase and peroxisomal beta-oxidation in mice and the sensitivity to endotoxin is greatest in C57BL/6J mice fed a high-fat diet.
249 HCC DIAGNOSED ON SURVEILLANCE PROGRAMMES: IMPACT ON STAGE AND OUTCOME
Authors: A. Ahmed, Z. Mustafa, M. Rutherford, M. Neilson, S. Ballantyne, R. Kasthuri, J. Evans, E.H. Forrest, R. Gillespie, S. Barclay, M. Priest, P. Mill, A. Stanley
Journal: Journal of Hepatology (2013)
Angiolymphoid hyperplasia with eosinophilia: successful treatment with pulsed dye laser using the double pulse technique
Authors: G. Gupta, C.S. Munro
Journal: British Journal of Dermatology (2000)

Journal Article Angiolymphoid hyperplasia with eosinophilia: successful treatment with pulsed dye laser using the double pulse technique Get access G. Gupta, G. Gupta Department of Dermatology, Southern General Hospital, Govan Road, Glasgow G51 4TF, U.K. Search for other works by this author on: Oxford Academic Google Scholar C.S. Munro C.S. Munro Department of Dermatology, Southern General Hospital, Govan Road, Glasgow G51 4TF, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 1, 1 July 2000, Pages 214–215, https://doi.org/10.1046/j.1365-2133.2000.03632.x Published: 01 July 2000
Cutaneous colonization with staphylococci influences the disease activity of Sézary syndrome: a potential role for bacterial superantigens
Authors: Y. TOKURA, H. YAGI, A. OHSHIMA, S. KUROKAWA, H. WAKITA, R. YOKOTE, S. SHIRAHAMA, F. FLIRUKAWA, M. TAKIGAWA
Journal: British Journal of Dermatology (2006)

It has previously been shown that circulating Sézary cells respond in vitro to superantigenic staphylococcal exotoxins in a manner that is restricted by their V beta usage. This study was conducted to examine whether cutaneous colonization with Staphylococcus aureus influences the activity of the skin lesions of Sézary syndrome, and whether S. aureus isolated from patients with Sézary syndrome stimulates circulating Sézary cells in vitro. Two patients with Sézary syndrome, whose skin was colonized with S. aureus, were treated with antibacterial agents, and the relation between the severity of the skin disease and the degree of S. aureus colonization was assessed. In addition, the patients' peripheral blood mononuclear cells were cultured in the presence of mitomycin C-treated S. aureus or superantigenic staphylococcal toxins. The antibacterial treatment improved the skin disease, and eliminated S. aureus in both patients. In one patient, 98% of the peripheral blood mononuclear cells bore V alpha 2V beta 17 of the T-cell receptor, indicative of the presence of an extremely high percentage of circulating Sézary cells. The peripheral blood lymphocytes from this patient responded well in vitro to superantigenic staphylococcal enterotoxin (SE), but not to SEA or toxic shock syndrome toxin-1, or to mitomycin-treated S. aureus isolated from the same patient. Cutaneous colonization by S. aureus influences the disease activity of CTCL, possibly by activation of Sézary cells by bacterial superantigenic exoproteins.
STUDIES ON A CASE OF PORPHYRIA CUTANEA TARDA.
Authors: G. C. WELLS, C. RIMINGTON
Journal: British Journal of Dermatology (1953)

Journal Article STUDIES ON A CASE OF PORPHYRIA CUTANEA TARDA. Get access G. C. WELLS, M.B., M.R.C.P., G. C. WELLS, M.B., M.R.C.P. Department of Dermatology and Nuffield Unit for the Investigation of Pyrrole Pigment Metabolism, Department of Chemical Pathology, University College Hospital Medical School, London Search for other works by this author on: Oxford Academic Google Scholar C. RIMINGTON, M.A., Ph.D., D.Sc. C. RIMINGTON, M.A., Ph.D., D.Sc. Department of Dermatology and Nuffield Unit for the Investigation of Pyrrole Pigment Metabolism, Department of Chemical Pathology, University College Hospital Medical School, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 65, Issue 10, 1 October 1953, Pages 337–351, https://doi.org/10.1111/j.1365-2133.1953.tb13165.x Published: 01 October 1953
Oncogenic MITF dysregulation in clear cell sarcoma: Defining the MiT family of human cancers
Authors: Ian J. Davis, Jessica J. Kim, Fatih Ozsolak, Hans R. Widlund, Orit Rozenblatt-Rosen, Scott R. Granter, Jinyan Du, Jonathan A. Fletcher, Christopher T. Denny, Stephen L. Lessnick, W. Marston Linehan, Andrew L. Kung, David E. Fisher
Journal: Cancer Cell (2006)
Does the Extent of Lymphadenectomy in Radical Cystectomy for Bladder Cancer Influence Disease-Free Survival? A Prospective Single-Center Study
Authors: Hassan Abol-Enein, Derya Tilki, Ahmed Mosbah, Mahmoud El-Baz, Ahmed Shokeir, Adel Nabeeh, Mohamed A. Ghoneim
Journal: European Urology (2011)
Renal Amyloidosis and Subcutaneous Drug Abuse
Authors: KATHLEEN H. MEADOR
Journal: Annals of Internal Medicine (1979)

Two drug addicts who practiced subcutaneous injection of crushed tripelennamine and pentazocine tablets, a practice known as "skin-popping," developed nephrotic syndrome and demonstrated amyloidosis on renal biopsy. These patients had chronic inflammation of the skin in the form of abscesses and ulcerations. Although both patients were long-standing drug abusers, they had practiced intradermal drug administration for only 3 years. The occurrence of amyloidosis in these patients appears to relate to their particular drug habit and must be considered in the differential diagnosis of proteinuria in this patient population.
Abstract 5472: Role of Harvey Ras (HRAS) mutations in head and neck squamous cell carcinoma (HNSCC)
Authors: Katharina U. Endhardt, Arun Khattri, Michaela Keck, Johannes Braegelmann, Derya Mahmutoglu, Kelley Leung, Mohamed El Dinali, Damian Rieke, Ezra Cohen, Tanguy Seiwert
Journal: Cancer Research (2012)

Abstract Background: Harvey Ras (HRAS) was recently reported being mutated in head and neck squamous cell carcinomas (HNSCC) and likely plays an important role as an oncogene. The precise role of HRAS mutations for signaling and carcinogenesis of HNSCC remains to be determined. Methods: We completed mutational screening (Sanger Sequencing) for tissues and cell lines focused on the known hotspot mutations G12X and Q61X. Furthermore we performed viability testing for various cell lines and visualized the signaling-effects by itself, in presence of PI3K-, EGFR inhibitors and likewise in combination, by immunoblotting. After suppression of HRAS using siRNA, we determined the cell-viability. Results: In our study we sequenced 100 HNSCC tumor tissues and HNSCC cell lines and identified several canonical HRAS mutations. One cell line contained a G12D HRAS mutation and was further examined. Additional two cell lines with atypical HRAS variants were identified and compared to the classic hotspot mutated cell line. The viability for the mentioned cell lines were indicative of resistance to EGFR inhibition to different degrees. The protein activation levels in important signaling pathways (PI3K/MAPK) confirmed our viability data. HRAS signaling was primarily via PI3K/AKT. Silencing HRAS showed significantly decreased viability. Conclusions: Previous studies have shown that EGFR-targeting agents remain insufficient as single targeted therapy. HRAS appears to contribute to the EGFR-resistance of HNSCC. The canonical mutation G12D appears to signal primarily via PI3K and PI3K inhibitors may be effective. The G12D cell line model indicates a central role of mutated HRAS for signaling and viability consistent with role as a driver mutation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5472. doi:1538-7445.AM2012-5472
Navigating across medicine's electronic landscape, stopping at places with Pub or Central in their names
Authors: T. Delamothe
Journal: BMJ (2001)

Attempts to use the internet to free up access to the world's biomedical literature have resulted in several similarly named initiatives emerging over the past two years. PubMed Central, BioMed Central, and the Public Library of Science have joined the slightly older PubMed, which has a different function but a name similar enough to add to the confusion.

The debates around free access are some of the most important that have taken place in the three centuries of scientific publishing.1 Yet confusion about who wants to do what to whom is hampering this debate. This attempt to dispel some of the confusion was up to date at the time of writing, but given the speed at which medicine's electronic landscape is changing, it is likely to date fast.

#### Summary points

Several initiatives have recently emerged to provide free access to biomedical literature though the internet

Traditional publishers have been reluctant to join these initiatives because of fears about lost subscriptions

PubMed Central's “decentralised model” could be the trigger for greater publisher participation

The advent of free electronic journals—paid for by authors' charges—could profoundly change the publishing landscape

PubMed provides access via the world wide web to over 11 million Medline citations dating from the mid-1960s to the present. It covers 4300 journals devoted to medicine, nursing, dentistry, veterinary medicine, healthcare systems, and the preclinical sciences. PubMed also provides access to life science journals that are not indexed by Medline but have submitted their full text to PubMed Central (see below).

As well as providing access to these abstracts and citations, PubMed links to more than 2000 websites that provide full text articles (figure). Access to these full text articles usually entails registration, subscription fees, or some other form of payment, although bmj.com is free.

In the four years since PubMed was …
Efficacy of Commercial Weight-Loss Programs
Authors: Kimberly A. Gudzune, Ruchi S. Doshi, Ambereen K. Mehta, Zoobia W. Chaudhry, David K. Jacobs, Rachit M. Vakil, Clare J. Lee, Sara N. Bleich, Jeanne M. Clark
Journal: Annals of Internal Medicine (2015)

Commercial and proprietary weight-loss programs are popular obesity treatment options, but their efficacy is unclear.To compare weight loss, adherence, and harms of commercial or proprietary weight-loss programs versus control/education (no intervention, printed materials only, health education curriculum, or <3 sessions with a provider) or behavioral counseling among overweight and obese adults.MEDLINE and the Cochrane Database of Systematic Reviews from inception to November 2014; references identified by program staff.Randomized, controlled trials (RCTs) of at least 12 weeks' duration; prospective case series of at least 12 months' duration (harms only).Two reviewers extracted information on study design, population characteristics, interventions, and mean percentage of weight change and assessed risk of bias.We included 45 studies, 39 of which were RCTs. At 12 months, Weight Watchers participants achieved at least 2.6% greater weight loss than those assigned to control/education. Jenny Craig resulted in at least 4.9% greater weight loss at 12 months than control/education and counseling. Nutrisystem resulted in at least 3.8% greater weight loss at 3 months than control/education and counseling. Very-low-calorie programs (Health Management Resources, Medifast, and OPTIFAST) resulted in at least 4.0% greater short-term weight loss than counseling, but some attenuation of effect occurred beyond 6 months when reported. Atkins resulted in 0.1% to 2.9% greater weight loss at 12 months than counseling. Results for SlimFast were mixed. We found limited evidence to evaluate adherence or harms for all programs and weight outcomes for other commercial programs.Many trials were short (<12 months), had high attrition, and lacked blinding.Clinicians could consider referring overweight or obese patients to Weight Watchers or Jenny Craig. Other popular programs, such as Nutrisystem, show promising weight-loss results; however, additional studies evaluating long-term outcomes are needed.None. (CRD4201-4007155).
Hydatid Disease of the Lung
Authors: J. G. Edwards
Journal: BMJ (1945)

<h3>Introduction</h3> Antineoplastic drugs, also known as hazardous drugs, are used to treat cancer. Healthcare workers’ exposure to these agents may lead to DNA damage and adverse reproductive effects. Exposure to antineoplastic drugs can be assessed via biological monitoring. <h3>Objectives</h3> To conduct a literature review of studies examining biological monitoring of healthcare workers exposed to antineoplastic drugs to identify trends and knowledge gaps. <h3>Methods</h3> The literature search was performed on three databases: Proquest, Web of Science and PubMed. For inclusion, an article had to be in English and published between 2005 and 2020. Search terms included ‘antineoplastic drugs’ or ‘hazardous drugs’ AND ‘occupational’ or ‘healthcare workers’ or ‘pharmacist’ or ‘nurse’ AND ‘blood’ or ‘urine’ or ‘biomarkers’. <h3>Results</h3> Overall, the literature review resulted in 70 unique articles - 30 examined urine as the matrix, 31 had non-urine samples and nine papers collected both urine and non-urine samples. Regarding the urine sampling studies, researchers collected either spot samples or 24-hr voids. Cyclophosphamide was the most common analyte (69%) with a detection limit ranging from 0.09 to 0.20 ng/ml. Approximately 75% of the articles reported at least one urine sample had detectable levels of drug. In some instances, urinary drug contamination was found even though workers wore personal protective equipment. For those studies that collected other matrices, blood and exfoliated buccal cells were the most common specimens. A majority (81%) reported that there was a statistically significant difference in results between exposed and non-exposed populations. Many studies reported that safe work practices, which includes the use of personal protective equipment, may not be adequate to protect healthcare workers. <h3>Conclusion</h3> There is value in conducting biological monitoring to assess healthcare workers’ exposure to antineoplastic drugs. However, because of the variability in sampling and analytical methods, standardization is recommended to ensure biological monitoring results are comparable.
Mycobacterium fortuitum glycolipids for the serodiagnosis of pulmonary tuberculosis.
Authors: L Escamilla, R Mancilla, W Glender, L M López-Marín
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Glycolipids belonging to the family of acylated trehaloses were isolated from Mycobacterium fortuitum, a rapidly growing mycobacterial species, and tested in the serologic diagnosis of human pulmonary tuberculosis by enzyme-linked immunosorbent assay. Di- and tri-O-acylated trehaloses from M. fortuitum reacted with serum antibodies of patients with pulmonary tuberculosis at higher titers than did with sera from healthy donors. With both glycolipids, the sensitivity of the test was above 0.80 at a chosen specificity of 0.98. Individuals with treated tuberculosis showed lower antibody titers compared with their initial reactivities. These data show that M. fortuitum could be used as a surrogate source of antigens for tuberculosis serodiagnosis.
Plasminogen activator inhibitor‐1 levels determine the profibrinolytic response in disseminated intravascular coagulation
Authors: L. Javier Garciá‐Frade, Jose A. Lorente, Angel Garciá‐Avello, Raul De Pablo, Luis Landín
Journal: American Journal of Hematology (1992)

TABLE 1. Plasma PAI-1 (nglml) Levels in Patients with Sepsis (Values Are Median [Range])t Day I Day 7quently altered, and 50% of the mutations were identical to that observed in our patient [9,10].The role of N-rus activation in y HCD and whether other oncogene abnormalities are also present are unknown; nonetheless, the identical mutation in tumors of related lineage deserves notice.
CHRONIC ROENTGEN-RAY DERMATOSES AS SEEN IN THE PROFESSIONAL MAN
Authors: H. N. COLE
Journal: JAMA (1925)

In 1896, Marcuse<sup>1</sup>first called attention to the dangers incident to exposure to the roentgen ray—the production of an alopecia and of a dermatitis "resembling sunburn." In the short space of twenty-eight years, how much valuable knowledge has been discovered concerning this wonderful physical agent? Incidentally, how many workers have learned to their own cost the dangers ensuing from being fully exposed to its unseen rays? In the early days, many a martyr to science was known, and the result was a long list of fatalities extending from 1898 to 1912. As the result of education and prophylactic measures, this list has since rapidly declined. Nevertheless, in the last few years, with the increasingly wide use of the roentgen ray by many physicians and dentists for picture work, for fluoroscopic work and for treatment, the question arises whether it will not be well to sound a new warning on