tbuckley/cabot-search huggingface dataset:
Van Gieson, a Visionary of Psychiatric Research
Authors: LEON ROIZIN
Journal: American Journal of Psychiatry (1970)

The author evaluates the significance of van Gieson`s pioneering work and original concepts in relation to the historical development of research in psychiatry and the foundation of the Pathological Institute of the New York State Hospitals for the Insane, the first multidisciplinary research institute in the Western hemisphere for the investigation and treatment of diseases of the nervous system.
Inflammatory Lesions of the Peritoneum Mimic Carcinomatosis After Treatment With Intravenous Chemotherapy and Intraperitoneal Catumaxomab
Authors: Jörn Rüssel, Alexander Stein, Curd Behrmann, Steffen Hauptmann, Patrick Krummenerl, Hans-Joachim Schmoll, Dirk Arnold
Journal: Journal of Clinical Oncology (2011)

Case ReportIn December 2007, a 54-year-old man was diagnosed with a diffusely growing, poorly differentiated (G3) gastric adenocarcinoma that was staged as T3Nϩ on the basis of an endoscopic ultrasound (EUS), computed tomography (CT) scan, and histologic evaluation of biopsies.Liver metastases and a bone lesion at the T9 level that were suggested by the CT scan were not confirmed by magnetic resonance imaging.The patient's medical history included recurrent gastric ulcers (Helicobacter pylori positive).The patient was enrolled onto a prospective phase II study (Multicenter, Open-Label Phase II Study to Evaluate the Safety and Efficacy of the Trifunctional Bispecific Antibody Catumaxomab [Anti-EpCAM ϫ Anti-CD3] in Patients With Gastric Adenocarcinoma After Neoadjuvant Chemotherapy and Intended Curative Resection) that was designed to evaluate the safety and efficacy of adding intra-and postoperative intraperitoneal (IP) catumaxomab (given at the end of surgery and on postoperative days 7, 10, 13, and 16) to a perioperative standard chemotherapy regimen, followed by gastrectomy.From January 2008 on, and within the preoperative period of the trial, the patient underwent three cycles of chemotherapy beginning at weeks 1, 4, and 7. Epirubicin (50 mg/m 2 ) and cisplatin (60 mg/m 2 ) were given intravenously and oral capecitabine (625 mg/m 2 ) was administered in two daily doses on days 1 through 21.In April 2008, the patient was readmitted for restaging, and a CT scan and gastroscopy/EUS were performed.The CT scan did not show any visceral metastases or nodal manifestations.The gastroscopy demonstrated no evidence of the primary tumor at the aforementioned location macroscopically, but scattered cicatricial areas of mucosa in the previously described location of the tumor were found.Within the possible location of the malignancy, the EUS demonstrated thickening of the stomach wall (maximum diameter of 10 mm), with evidence of a hypoechoic mass with a maximum diameter of 22 mm
Are Nursing Home Diagnosis and Treatment Inadequate?
Authors: Thomas D. Sabin
Journal: JAMA (1982)

THERE ARE about 60,000 patients—mostly elderly—in Massachusetts nursing homes and hospitals for the chronically ill, and 37,000 are paid for by Medicaid. The services rendered to these patients cost more than half a billion dollars annually, and this includes approximately half the total Medicaid dollars expended by the Commonwealth of Massachusetts (personal communication, Department of Public Welfare, Medicaid Division, Commonwealth of Massachusetts, February 1982). These figures reflect a growing national problem; 1.5% of the population in the United States between the ages of 65 and 74 years, 6% between 75 and 84 years, and 20% of those older than 85 years are institutionalized in hospitals for the chronically ill or in nursing homes. This group is a rapidly growing segment of our population. A more depressing statistic shows that elderly patients institutionalized for longer than six months have little chance of being discharged, unless it is for transfer to a
A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation
Authors: F Abate, M Todaro, J-A van der Krogt, M Boi, I Landra, R Machiorlatti, F Tabbò, K Messana, C Abele, A Barreca, D Novero, M Gaudiano, S Aliberti, F Di Giacomo, T Tousseyn, E Lasorsa, R Crescenzo, L Bessone, E Ficarra, A Acquaviva, A Rinaldi, M Ponzoni, D L Longo, S Aime, M Cheng, B Ruggeri, P P Piccaluga, S Pileri, E Tiacci, B Falini, B Pera-Gresely, L Cerchietti, J Iqbal, W C Chan, Leonard D Shultz, I Kwee, R Piva, I Wlodarska, R Rabadan, F Bertoni, G Inghirami
Journal: Leukemia (2014)
The Campaign against Smokeless Tobacco
Authors: C. Everett Koop
Journal: New England Journal of Medicine (1986)

IN 1985, the United States produced nearly 140 million lb (64 million kg) of an addictive substance, the use of which is growing at an appalling rate among male youths and young adults.1 It is easy to get and easy to use, and it offers an easy way for teenage boys to bolster their "macho" image. This substance, a smokeless form of tobacco, has reemerged as a popular product for the first time since the turn of the century. As summarized in an article in this issue2 and concluded in a recent report to the Surgeon General by the Advisory . . .
Doublethink in Lupus Nephritis
Authors: Eli A. Friedman
Journal: JAMA (1980)

Selecting a treatment strategy for azotemic patients with lupus nephritis is a stress-inducing exercise. It has been suggested that the type and extent of glomerular abnormalities offer the best guidance for therapy. Study of percutaneous renal biopsy specimens from patients with systemic lupus erythematosus (SLE) who have proteinuria, gross or microscopic hematuria, or a diminished creatinine clearance will in almost all instances discover pathological changes in glomeruli. Mild glomerular pathological changes transform to diffuse proliferative glomerulonephritis sufficiently frequently, however, to preclude constant association of a benign clinical course with a favorable biopsy specimen.<sup>1</sup>Changes from severe proliferative to membranous glomerulonephritis, from focal or diffuse proliferative glomerulonephritis to membranous glomerulonephritis, and from membranous to diffuse proliferative glomerulonephritis occur, indicating the folly of dogmatically ascribing any clinical syndrome to a fixed histological glomerular pattern. While it is generally true that development of diffuse proliferative glomerulonephritis in SLE is an ominous prognostic
Points from Letters: Medical Staff Dining-rooms
Authors: H. Jacobs
Journal: BMJ (1973)

JouRNAL 28 juLY 1973 already being made, and I would anticipate a successful outcome in due course.(2) So far as women doctors are con- cerned, they are in an unusual position in that for all service prior to March 1972 they will on retirement receive a substantial lump sum in lieu of a widower's pension.This lump sum is not received by a mar- ried man and pays for a half-pension for his widow.In the vast majority of cases the lump sum, received by the woman doctor and properly used, is worth more to the possible widower than the alternative pen- sion which might have been paid on the death of the woman doctor.(3) All this applies to service prior to March 1972, and the situation is quite different for service after March 1972, since for this the lump payment will not be de-
Abstract 5277: Latent transforming growth factor beta-binding protein-3 interacts with midkine
Authors: Chunhua Weng, Haojie Dong, Zhengping Xu
Journal: Cancer Research (2014)

Abstract Midkine (MK) is a multifunctional heparin-binding growth factor with a molecular weight of 13 kDa, which plays important roles in carcinogenesis. In order to study the action mechanism of MK,we employed a yeast two-hybrid system to screen a human liver cDNA library to determine the putative MK-interacting proteins. cDNA clones containing nucleotide sequences which encode latent transforming growth factor -beta binding protein-3 (LTBP-3) were obtained. The MK/LTBP-3 interaction was confirmed by fluorescence resonance energy transfer analysis. Furthermore, the interaction was analyzed in detail by yeast two-hybrid assay and GST pull down assay. The binding site of MK in LTBP-3 was mapped to the center of the protein, a tandem array of EGF-like repeats, by a fragment deletion analysis in yeast two-hybrid system. The eighth EGF-like domain of LTBP3 plays a critical role in the MK/LTBP-3 interaction in GST pull down assay. On the other hand, four basic amino acids (K-79, R-81, K-86 and K-87) present within the heparin-binding cluster I and II of MK are necessary for the two proteins binding process. These results indicate that MK can bind to LTBP-3, and locate to the eighth EGF-like domain. The heparin-binding clusters of MK are a multifunctional domain, which provide a potential mechanism whereby MK may participate in the TGF-beta system to interfere in carcinogenesis. Note: This abstract was not presented at the meeting. Citation Format: Chunhua Weng, Haojie Dong, Zhengping Xu. Latent transforming growth factor beta-binding protein-3 interacts with midkine. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5277. doi:10.1158/1538-7445.AM2014-5277
Maintaining the Public Trust in Clinical Research
Authors: Robert P Kelch
Journal: New England Journal of Medicine (2002)

Financial conflicts of interest are present in many types of medical research. Until recently there has been no unified effort to address the many problems that arise because of such conflicts. The Association of American Medical Colleges recently approved guidelines for dealing with individual, as opposed to institutional, conflicts of interest. In this Sounding Board article, Kelch outlines the many features of the guidelines and urges their widespread adoption.
The Psychiatrist: Personality and Patterns
Authors: Marjorie C. Meehan
Journal: JAMA (1968)

Wouldn't you enjoy listening to the reminiscences and comments of an older physician who had personal contacts with many of the leaders in his field? Walter Freeman has held a prominent place in American psychiatry and neurology for many years and has been involved in much controversy. In this book he writes about psychiatrists as if he were just chatting, recalling personal experiences, anecdotes told him by friends, information and ideas culled from wide reading. He describes in some detail individual psychiatrists, ranging in time from Benjamin Rush (1746-1813) to some still living. He includes the well-known figures such as Freud, Jung, and Meyer and gives prominence to the leaders in physical therapy of mental illness, such as von Jauregg, Sakel, Meduna, Cerletti. He includes the "dynasties"— Menningers, Bullards, Grinkers. An essay on psychiatrists who kill themselves accompanies short biographies of eight who did so. In addition to the biographical
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells
Authors: Shawn A Mahmud, Luke S Manlove, Heather M Schmitz, Yan Xing, Yanyan Wang, David L Owen, Jason M Schenkel, Jonathan S Boomer, Jonathan M Green, Hideo Yagita, Hongbo Chi, Kristin A Hogquist, Michael A Farrar
Journal: Nature Immunology (2014)
Umbilical Cord Blood–derived Progenitor Cells Enhance Muscle Regeneration in Mouse Hindlimb Ischemia Model
Authors: Jonna K Koponen, Tuija Kekarainen, Suvi E Heinonen, Anita Laitinen, Johanna Nystedt, Jarmo Laine, Seppo Ylä-Herttuala
Journal: Molecular Therapy (2007)

Progenitor cell therapy is a potential new treatment option for ischemic conditions in the myocardium and skeletal muscles. However, it remains unclear whether umbilical cord blood (UCB)-derived progenitor cells can provide therapeutic effects in ischemic muscles and whether ex vivo gene transfer can be used for improving the effect. In this study, the use of a lentiviral vector led to efficient transduction of both UCB-derived hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Our method resulted in a long-term transgene expression and did not alter the differentiation potential of either HSCs or MSCs. In addition, we studied the therapeutic potential of CD133+ and MSC progenitor cells transduced ex vivo with lentiviruses encoding the mature form of vascular endothelial growth factor D (VEGF-DΔNΔC) or the enhanced green fluorescent protein (eGFP) marker gene in a nude mouse model of skeletal muscle ischemia. Progenitor cells enhanced the regeneration of ischemic muscles without a detectable long-term engraftment of either CD133+ or MSC progenitor cells. Our results show that, rather than directly participating in angiogenesis or skeletal myogenesis, UCB-derived progenitor cells indirectly enhance the regenerative capacity of skeletal muscle after acute ischemic injury. However, VEGF-D gene transfer of progenitor cells did not improve the therapeutic effect in ischemic muscles. Progenitor cell therapy is a potential new treatment option for ischemic conditions in the myocardium and skeletal muscles. However, it remains unclear whether umbilical cord blood (UCB)-derived progenitor cells can provide therapeutic effects in ischemic muscles and whether ex vivo gene transfer can be used for improving the effect. In this study, the use of a lentiviral vector led to efficient transduction of both UCB-derived hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Our method resulted in a long-term transgene expression and did not alter the differentiation potential of either HSCs or MSCs. In addition, we studied the therapeutic potential of CD133+ and MSC progenitor cells transduced ex vivo with lentiviruses encoding the mature form of vascular endothelial growth factor D (VEGF-DΔNΔC) or the enhanced green fluorescent protein (eGFP) marker gene in a nude mouse model of skeletal muscle ischemia. Progenitor cells enhanced the regeneration of ischemic muscles without a detectable long-term engraftment of either CD133+ or MSC progenitor cells. Our results show that, rather than directly participating in angiogenesis or skeletal myogenesis, UCB-derived progenitor cells indirectly enhance the regenerative capacity of skeletal muscle after acute ischemic injury. However, VEGF-D gene transfer of progenitor cells did not improve the therapeutic effect in ischemic muscles.
Brain Death with Prolonged Somatic Survival
Authors: Joseph E. Parisi, Ronald C. Kim, George H. Collins, Martin F. Hilfinger
Journal: New England Journal of Medicine (1982)

IT is widely held that in patients with brain death who are receiving continued ventilation and full medical care, spontaneous cessation of the heartbeat will ensue within a period of hours or a few days.1 2 3 In this report, we describe a middle-aged man in whom a number of generally accepted sets of clinical criteria for brain death were met, and in whom cardiac activity ceased only after ventilatory support was discontinued over two months later.Case ReportA 49-year-old man with a prior history of heart disease and psychiatric illness had a cardiorespiratory arrest during a physical altercation. Cardiopulmonary resuscitation . . .
Longitudinal analysis of changes in early HCV kinetics following the addition of ribavirin to IFN monotherapy
Authors: J.E.M. Medeiros-Filho, A.U. Neumann, J.R.R. Pinho, I.M.V.G.C. Mello, M.F. Lemos, L.C. Da Silva, A.A. Laudann, F.J. Carrilho
Journal: Journal of Hepatology (2002)
Loricrin keratoderma: a cause of congenital ichthyosiform erythroderma and collodion baby.
Authors: K. Matsumoto, M. Muto, S. Seki, T. Saida, N. Horiuchi, H. Takahashi, A. Ishida-Yamamoto, H. Iizuka
Journal: British Journal of Dermatology (2001)

A group of hereditary palmoplantar keratodermas due to heterozygous mutation in the loricrin gene has recently been identified. Of five reported pedigrees, four presented as mutilating keratoderma with ichthyosis (variant Vohwinkel syndrome), and one as progressive symmetric erythrokeratoderma. We report a new Japanese pedigree of loricrin keratoderma. A 14-year-old male and his 11-year-old female sibling had both been born as collodion babies and were initially diagnosed as having non-bullous congenital ichthyosiform erythroderma, but later developed palmoplantar keratoderma with pseudoainhum. Their father was similarly affected. Direct sequencing of genomic DNA revealed a G residue insertion at codon 230–231 of the loricrin gene. Antibody studies confirmed the presence of mutant loricrin in the retained nuclei. We conclude that loricrin gene mutation may present as congenital ichthyosiform erythroderma, and should be included in the differential diagnosis of collodion baby.
Handbook of Clinical Nuclear Medicine
Authors: Adolph J. Rabinovitz
Journal: JAMA (1978)

Nuclear medicine has appeared as an important new diagnostic modality in the last decade. In some areas it has added critical new information to the medical decision-making process, but time is needed to apply the newly available procedures and derived data to daily practice. This book is prepared as a guide for the physician who is not a specialist in nuclear medicine. Each chapter, laid out in a uniform format, deals with the scanning of a different organ. Physiological factors, pertinent anatomic facts, radiopharmaceuticals, technical comments, and indications for scanning the particular organ form the introductory portion of each chapter. This is followed by a description of the appearances of the normal scans and the salient features of the abnormal findings in common conditions, with frequent references to the operative pathophysiological factors. The chapters end with a brief section on disadvantages and source of errors in interpretation. Indications for the
Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice
Authors: Jordi Farrés, Juan Martín-Caballero, Carlos Martínez, Juan J. Lozano, Laura Llacuna, Coral Ampurdanés, Cristina Ruiz-Herguido, Françoise Dantzer, Valérie Schreiber, Andreas Villunger, Anna Bigas, José Yélamos
Journal: Blood (2013)
New standards for cardiopulmonary resuscitation
Authors: Charles D Deakin
Journal: BMJ (2005)

<h3>Background and Objectives:</h3> The fentanyl HCl iontophoretic transdermal system (ITS) has been demonstrated in clinical trials to be safe and effective for acute-pain management after several types of major surgery. The current study compared the efficacy, safety, and convenience of fentanyl ITS with morphine intravenous patient-controlled analgesia (IV PCA) for acute-pain management after unilateral total-hip replacement (THR). <h3>Methods:</h3> In this multicenter (52 sites), randomized, open-label, active-controlled, phase IIIb study, patients (n = 799) received fentanyl ITS (40 μg fentanyl [10-minute infusion/lockout], up to 6 doses/h) or morphine IV PCA (1-mg morphine bolus [5-minute lockout], up to 10 mg/h) after unilateral THR. The primary efficacy measure was success ratings (“excellent” or “good”) on the patient global assessment (PGA) of the method of pain control in the first 24 hours. Pain intensity and adverse events were also assessed. <h3>Results:</h3> The PGA success ratings (83.0% <i>v</i> 82.2%; difference = 0.9%; 95% CI: −4.4% to 6.1%) and the mean last pain-intensity scores (3.0 <i>v</i> 3.0; difference = 0.0; 95% CI: −0.33 to 0.33) in the first 24 hours were statistically equivalent between fentanyl ITS and morphine IV PCA groups, respectively. The incidence of adverse events was similar between the groups. <h3>Conclusions:</h3> Results of this study demonstrate fentanyl ITS and a standard regimen of morphine IV PCA were comparable methods of pain control for management of acute postoperative pain after THR, on the basis of the PGA success ratings and pain intensity in the first 24 hours of treatment.
Contaminated infant formula sickens 6200 babies in China
Authors: J. Parry
Journal: BMJ (2008)

More than 6200 babies have become ill in China as a result of drinking infant formula made from milk contaminated with the industrial chemical melamine.

China’s health minister Chen Zhu at a press conference on 17 September, said, “Three babies have died of kidney failure, 158 more have acute kidney failure and 1327 babies remain in hospital.” A day later the death toll rose to four.

Melamine, used to boost the protein concentration of cow’s milk when it is tested before sale to milk product manufacturers, was first found in baby formula manufactured by the state owned Sanlu Group, based in Shijiazhuang, the capital of Hebei province, and …
Fluoride Safety and Efficacy
Authors: J. H. WEISBURGER, G. WILLIAMS, E. L. WYNDER
Journal: JNCI Journal of the National Cancer Institute (1990)

Fluoride Safety and EfficacyIn a recent paper, Maurer et al (7) reported on an extensive study of the potential chronic toxicity and carcinogenicity of three dose levels of sodium fluoride in Sprague-Dawley rats.At the higher dosages, weight gain was depressed, signifying that the test was properly conducted at the maximally tolerated dose, and lethality was not observed.The ingestion of fluoride led to changes in bone and teeth, an expected phenomenon, but there was no evidence of any carcinogenic effect.This study provides perspective on a recently published study (2), by the US National Toxicology Program (NTP), which was widely reported and discussed (3,4).In the NTP study, osteosarcomas developed in 4 of 80 male Fischer rats, at an intake of 175 ppm of sodium fluoride in drinking water, and a sarcoma developed in 1 rat at the level of 100 ppm.No neoplasms were found at 25 ppm of fluoride or in untreated controls.Female rats and mice of both sexes had no such tumors.In a commentary on this study, the suggestion was advanced that a positive finding would have implications regarding the safety of fluoride consumption (3,4).Such a suggestion is important because of the extensive use of fluoride in drinking water.In the 1940s at the National Institute of Dental Research (National Institutes of Health, Bethesda, Md), fluoridation was discovered to have a significant protective effect in preventing dental caries (5,6).This finding has been confirmed, and many municipalities provide adequate fluoride levels in water.In areas with fluoridated water, dental health is better than in unfluoridated control regions.Because of a prophylactic effect of fluoride, many dentifrices now include fluoride.Therefore, demonstration or even a suspicion that fluoride, at high dose levels, might be unsafe and/ or carcinogenic requires very careful analysis.
Unusual Tc-99m MAG3 Uptake in Unknown Bone Metastases
Authors: Naureen Nizar, Akhtar Ahmed
Journal: Clinical Nuclear Medicine (2009)

A 55-years-old female patient with a diagnosis of transitional cell carcinoma of the urinary bladder and a right hydronephrotic kidney1 was referred for evaluation of renal function. On Tc-99m MAG3 scan, abnormal accumulation of tracer2 was noted in the region of the right sacroiliac joint with nonvisualization of the right kidney. Subsequent correlation with CT scan and Tc-99m MDP bone scintigraphy confirmed the Tc-99m MAG3 uptake in a metastasis involving the right sacroiliac joint.3–8