tbuckley/cabot-search huggingface dataset:
In patients with severe sepsis, adding albumin to crystalloid solution did not reduce 28- or 90-day mortality
Authors: B. Taylor Thompson
Journal: Annals of Internal Medicine (2014)

ACP Journal Club15 July 2014In patients with severe sepsis, adding albumin to crystalloid solution did not reduce 28- or 90-day mortalityB. Taylor Thompson, MDB. Taylor Thompson, MDMassachusetts General Hospital, Boston, Massachusetts, USA (B.T.T.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-161-2-201407150-02006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationCaironi P, Tognoni G, Masson S, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med. 2014;370:1412-21. https://pubmed.ncbi.nlm.nih.gov/24635772Clinical Impact RatingsHospitalists: Infectious Disease: Critical Care: References1 Finfer S, Bellomo R, Boyce N, et al; SAFE Study Investigators. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350:2247-56. [PMID: 15163774] Google Scholar2 Finfer S, McEvoy S, Bellomo R, et al; SAFE Study Investigators. Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis. Intensive Care Med. 2011;37:86-96. [PMID: 20924555] Google Scholar3 Delaney AP, Dan A, McCaffrey J, Finfer S. The role of albumin as a resuscitation fluid for patients with sepsis: a systematic review and meta-analysis. Crit Care Med. 2011;39:386-91. [PMID: 21248514] Google Scholar4 Russell JA. Is there a good MAP for septic shock? N Engl J Med. 2014;370:1649-51. [PMID: 24635771] Google Scholar5 Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41:580-637. [PMID: 23353941] Google Scholar Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital, Boston, Massachusetts, USA (B.T.T.)This article was published at Annals.org on 1 July 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIn septic shock, MAP targets of 80 to 85 mm Hg vs 65 to 70 mm Hg did not differ for 28-day mortality B. Taylor Thompson Metrics 15 July 2014Volume 161, Issue 2Page: JC6KeywordsAlbuminsIntensive care unitsResuscitationSepsisVasopressorsVentilators ePublished: 15 July 2014 Issue Published: 15 July 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Liver-Spleen Imaging in Patients with Subacute Hepatic Necrosis and Chronic Hepatitis
Authors: G J FISCHER, E V STAAB, H R LESESNE, W H McCARTNEY
Journal: Clinical Nuclear Medicine (1980)

Tc-99m-sulfur colloid reticuloendothelial images and percutaneous liver biopsies are correlated in 54 patients who presented with signs and symptoms of subacute hepatic necrosis or chronic active hepatitis. The scored Tc-99m-sulfur colloid scan is compared to the histological severity of disease. Serial scans and biopsies are compared. In patients with significant hepatocellular disease, the liver-spleen scan did not correlate well with the histological severity of disease. Changes in the spleen-to-liver ratio are more common than those in the liver or increased bone marrow activity, and appear earlier. In serial studies, changes in the Tc-99m-sulfur colloid scans correlate weakly with changes in histology.
Case 9-1961
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. Kibbee
Journal: New England Journal of Medicine (1961)

Presentation of Case A seventy-five-year-old woman entered the hospital because of weakness. For several months before admission she was weak and anorectic and lost weight. She was said to have fallen on at least one occasion. Twelve years previously digitalis therapy was given and a low-salt diet prescribed because of congestive heart failure, which was attributed to arteriosclerotic heart disease. The blood pressure was 175 systolic, 75 diastolic. The patient was known to have diabetes mellitus for eleven years before entry. She failed to follow a dietary regimen, and the diabetes was controlled with insulin therapy. Two years before admission . . .
Analysis of T-Wave Morphology From the 12-Lead Electrocardiogram for Prediction of Long-Term Prognosis in Male US Veterans
Authors: Markus Zabel, Marek Malik, Katerina Hnatkova, Vasilios Papademetriou, Andreas Pittaras, Ross D. Fletcher, Michael R. Franz
Journal: Circulation (2002)

Background — The aim of the present study was to assess the prognostic value of novel repolarization descriptors from the 12-lead ECG in a large cohort of US veterans. Methods and Results — Male US veterans (n=813) with cardiovascular disease had digital 12-lead ECGs recorded at the VA Medical Center, Washington, DC, between 1984 and 1991. The patient series was retrospectively compiled in 1991; follow-up was prospectively assessed until 2000. Novel ECG variables characterizing repolarization and the T-wave loop were automatically analyzed. Of 772 patients with technically analyzable data, 252 patients (32.6%) died after a mean follow-up of 10.4±3.8 years. Direct comparison between dead and alive patients showed that the so-called T-wave residua (the absolute and relative amount of nondipolar contents within the T wave) predicted mortality (111 900±164 700 versus 85 600±144 800 between dead and alive patients, P &lt;0.0002; and 0.43±0.62% versus 0.33±0.56%, P &lt;0.0005 for the absolute and relative T-wave residuum, respectively). On Cox regression analysis entering age, left ventricular ejection fraction, echocardiographic left ventricular hypertrophy, and either of the T-wave residua, risk prediction was independent for the absolute ( P =0.022) and for the relative ( P =0.006) T-wave residuum, respectively, with age ( P &lt;0.0001), presence of left ventricular hypertrophy ( P =0.002), and left ventricular ejection fraction ( P =0.004) also being predictors of survival. Conclusions — The heterogeneity of myocardial repolarization, measured by the so-called T-wave residuum in the ECG, confers long-term independent prognostic information in US veterans with cardiovascular disease.
Atherosclerotic Aortic Occlusion
Authors: Thanila A Macedo
Journal: New England Journal of Medicine (2005)

This 46-year-old woman had lifestyle-limiting claudication of the legs. She had hypertension, hyperlipidemia, and a history of smoking. A computed tomographic angiogram showed aortic occlusion just below the origin of the renal arteries (red arrowhead).
Tropical Splenomegaly Syndrome: Long-term Proguanil Therapy Correlated with Spleen Size, Serum IgM, and Lymphocyte Transformation
Authors: A.-S. Sagoe
Journal: BMJ (1970)

Forty-three patients with an initial diagnosis of tropical splenomegaly syndrome were placed on long-term proguanil therapy. All patients who failed to respond to proguanil and who were adequately followed up developed identifiable disease, usually malignant lymphoma or chronic lymphatic leukaemia. In patients who responded to proguanil IgM values were always very high and phytohaemagglutinin (P.H.A.)-lymphocyte-transformation scores were always normal before treatment was started. In patients who failed to respond IgM values were within the normal range or below, while P.H.A.-lymphocyte-transformation scores were abnormally low. During proguanil treatment IgM values fell gradually, closely paralleling the decrease in spleen size.
Postoperative radiotherapy can improve chances of survival in some lung cancer patients
Authors: David Spurgeon
Journal: BMJ (2006)

A new study of 7465 patients who underwent surgery for lung cancer shows that radiotherapy can improve the chances of long term survival in certain patients. The study, published online on 12 June in the Journal of Clinical Oncology (www.jco.org, doi:10.1200/JCO.2005.04.6110) suggests reconsidering the role of radiotherapy in the treatment of lung cancer.

Brian Lally, a radiation oncologist at Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, and the study's lead author, said: “Postoperative radiotherapy has failed to demonstrate a survival benefit in the past, …
Tyrosine kinases, drugs, and<i>Shigella flexneri</i>dissemination
Authors: Ana-Maria Dragoi, Hervé Agaisse
Journal: Gut Microbes (2013)

Shigella flexneri is an enteropathogenic bacterium responsible for approximately 100 million cases of severe dysentery each year. S. flexneri colonization of the human colonic epithelium is supported by direct spread from cell to cell, which relies on actin-based motility. We have recently uncovered that, in intestinal epithelial cells, S. flexneri actin-based motility is regulated by the Bruton's tyrosine kinase (Btk). Consequently, treatment with Ibrutinib, a specific Btk inhibitor currently used in the treatment of B-cell malignancies, effectively impaired S. flexneri spread from cell to cell. Thus, therapeutic intervention capitalizing on drugs interfering with host factors supporting the infection process may represent an effective alternative to treatments with antimicrobial compounds.
A Flexible Thin Needle for Transbronchial Aspiration Biopsy Through the Flexible Fiberoptic Bronchoscope
Authors: R. Lundgren
Journal: Endoscopy (1980)

A new flexible thin needle for transbronchial aspiration biopsy through the flexible fiberoptic bronchoscope has been developed. The instrument is described and the experience gained in 53 transbronchial punctures is reported. The needle is a suitable adjunct to other accessories for use with the flexible fiberoptic bronchoscope.
The Process of Neurologic Care in Medical Practice
Authors: George W. Paulson
Journal: JAMA (1984)

<i>The Process of Neurologic Care</i>was difficult to review and difficult to read, but deserves to be in many libraries for family practitioners and neurologists. The author is a sympathetic consultant for primary caregivers, having observed that many in practice are alienated from formal neurological education and are convinced that all can benefit from discussion of hidden and understated approaches to care. Quality of care can improve with positive education, even about attitudes, and although ostensibly intending to educate the nonneurologist, the author discloses neurological tricks of the trade. He also uses numerous brief cases that must have appeared in teaching conferences on the neurology service at Cambridge (Mass) Hospital, where Dr Glick is chief of services. There are 48 complex tables on pitfalls, causes, and red flags and numerous lists of illustrative questions and aphorisms. In addition, there is discussion of rarely mentioned techniques, such as use of corneal
Technical crystallization for application in pharmaceutical material engineering: Review article
Authors: Abdul Khaliq El-Zhry El-Yafi, Hind El-Zein
Journal: Asian Journal of Pharmaceutical Sciences (2015)

In recent years, engineering the total morphology of pharmaceutical materials particles to desirable shape, size and surface area has long been actively increased because it has many advantages especially for improving physicochemical properties of Active Pharmaceutical Ingredients (APIs). This article therefore considers the potential utility of crystal engineering as a tool for controlling and designing properties of pharmaceutical solid particles in purpose to developing efficacious performance of solid dosage form, fundamentals of crystallization process, applications. In addition, understanding the relationship between molecular recognition, thermodynamic, and kinetics which controls the crystallization process so that it benefits in designing successful experiments to have desirable crystal habit for materials.
Abnormal spatial dispersion of QRS duration predicts mortality in patients with mild to moderate chronic heart failure
Authors: Takahisa Yamada, Masatake Fukunami, Tsuyoshi Shimonagata, Kazuaki Kumagai, Akio Hirata, Mitsutoshi Asai, Nobuhiko Makino, Hidetaka Kioka, Noritake Hoki
Journal: Journal of the American College of Cardiology (2002)
The Efficacy of Tricyclic Antidepressants
Authors: Maxwell Sobel
Journal: JAMA (1988)

<h3>To the Editor. —</h3> In the July 15 issue of<i>JAMA</i>, Dr Renshaw<sup>1</sup>presents a case discussion of the use of a tricyclic antidepressant in treating a young woman with interstitial cystitis and depression. While I found the case interesting, I take issue with the assumption that the presence of anticholinergic side effects means a therapeutic blood level has been attained. This is simply not a reliable estimate of efficacy. There seems to be little or no relationship between established therapeutic blood levels of tricyclic antidepressants and the anticholinergic side effects seen in approximately 15% of patients taking these agents.<sup>2</sup> The presence of "dry mouth and eyes" only signifies the patient's individual sensitivity to this effect. I have seen several patients develop these side effects when taking small doses with negligible blood levels, far below levels shown to be therapeutic. The custom of predicting blood levels and determining
DISTRIBUTION OF TYPES OF INVASION IN GREAT VESSELS OF 52 SUBJECTS WITH TAKAYASU ARTERITIS EVALUATED BY MULTISLICE COMPUTED TOMOGRAPHY: A MEDIAN OF 15.5 YEARS FOLLOW UP FROM ONSET
Authors: Hiroyuki Takaoka, Nobusada Funabashi, Koya Ozawa, Yoshio Kobayashi
Journal: Journal of the American College of Cardiology (2014)
Bone-Marrow Transplantation for Hematologic Neoplasia in 16 Patients with Identical Twins
Authors: Alexander Fefer, Albert B. Einstein, E. Donnall Thomas, C. Dean Buckner, Reginald A. Clift, Harold Glucksberg, Paul E. Neiman, Rainer Storb
Journal: New England Journal of Medicine (1974)

Abstract Sixteen patients (11 years to 67 years of age) with hematologic neoplasia refractory to conventional therapy were treated with cyclophosphamide (60 mg per kilogram per day on two occasions), a supralethal dose of total-body irradiation (1000 rads) and a bone-marrow transplant from a normal identical twin. Twelve patients also received immunotherapy consisting of subcutaneous injections of the patients' own leukemia cells lethally irradiated with 10,000 rads and intravenous infusions of peripheral blood lymphocytes from the normal twin. Fourteen patients experienced complete remissions. Six patients (two with acute lymphoblastic leukemia, three with acute myelogenous leukemia, and one with lymphosarcoma-leukemia) remained in complete remission at 11 to 44 months without any maintenance chemotherapy, and two others with acute myelogenous leukemia were in complete remission at two and three months. One patient died of viral hepatitis without leukemia. Five patients relapsed at three to seven months....
The Effect of Biomass Burning on Respiratory Symptoms and Lung Function in Rural Mexican Women
Authors: Justino Regalado, Rogelio Pérez-Padilla, Raúl Sansores, José Ignacio Páramo Ramirez, Michael Brauer, Peter Paré, Sverre Vedal
Journal: American Journal of Respiratory and Critical Care Medicine (2006)

Background: The use of biomass as a cooking fuel is commonplace in developing countries and has been associated with chronic bronchitis and obstructive airway disease.Methods: A cross-sectional survey was done in the village of Solis, close to Mexico City. Lifelong nonsmoking women 38 yr of age or older (n = 841) completed a questionnaire on respiratory symptoms and illnesses and on cooking fuel use, and performed spirometry in their homes. Particulate matter concentration was measured with a nephelometer in the kitchen for 1 h, while the subject was cooking.Results: The peak indoor concentration of particulate matter (PM10, particles with a diameter of 10 μm or less) often exceeded 2 mg/m3. Compared with those cooking with gas, current use of a stove burning biomass fuel was associated with increased reporting of phlegm (27 vs. 9%) and reduced FEV1/FVC (79.9 vs. 82.8%). Levels of FEV1 were 81 ml lower and cough was more common (odds ratio, 1.7; 95% confidence interval, 1.0–2.8) in women from homes with higher PM10 concentrations. All women found with moderate airflow obstruction (Global Initiative for Chronic Obstructive Lung Disease stage II and above) were cooking with biomass stoves.Conclusion: Women cooking with biomass fuels have increased respiratory symptoms and a slight average reduction in lung function compared with those cooking with gas.
Prognostic Value of Troponins in Acute Pulmonary Embolism
Authors: Cecilia Becattini, Maria Cristina Vedovati, Giancarlo Agnelli
Journal: Circulation (2007)

Whether elevated serum troponin levels identify patients with acute pulmonary embolism at high risk of short-term mortality or adverse outcome is undefined.We performed a meta-analysis of studies in patients with acute pulmonary embolism to assess the prognostic value of elevated troponin levels for short-term death and adverse outcome events (composite of death and any of the following: shock, need for thrombolysis, endotracheal intubation, catecholamine infusion, cardiopulmonary resuscitation, or recurrent pulmonary embolism). Unrestricted searches of MEDLINE and EMBASE bibliographic databases from January 1998 to November 2006 were performed using the terms "troponin" and "pulmonary embolism." Additionally, review articles and bibliographies were manually searched. Cohort studies were included if they had used cardiac-specific troponin assays and had reported on short-term death or adverse outcome events. A random-effects model was used to pool study results; funnel-plot inspection was done to evaluate publication bias; and I2 testing was used to test for heterogeneity. Data from 20 studies (1985 patients) were included in the analysis. Overall, 122 of 618 patients with elevated troponin levels died (19.7%; 95% confidence interval [CI], 16.6 to 22.8) compared with 51 of 1367 with normal troponin levels (3.7%; 95% CI, 2.7 to 4.7). Elevated troponin levels were significantly associated with short-term mortality (odds ratio [OR], 5.24; 95% CI, 3.28 to 8.38), with death resulting from pulmonary embolism (OR, 9.44; 95% CI, 4.14 to 21.49), and with adverse outcome events (OR, 7.03; 95% CI, 2.42 to 20.43). Elevated troponin levels were associated with a high mortality in the subgroup of hemodynamically stable patients (OR, 5.90; 95% CI, 2.68 to 12.95). Results were consistent for troponin I or T and prospective or retrospective studies.Elevated troponin levels identify patients with acute pulmonary embolism at high risk of short-term death and adverse outcome events.
Soluble Mesothelin, Megakaryocyte Potentiating Factor, and Osteopontin as Markers of Patient Response and Outcome in Mesothelioma
Authors: Kevin Hollevoet, Kristiaan Nackaerts, Robert Gosselin, Walter De Wever, Lionel Bosquée, Paul De Vuyst, Paul Germonpré, Eliane Kellen, Catherine Legrand, Yoshiro Kishi, Joris R. Delanghe, Jan P. van Meerbeeck
Journal: Journal of Thoracic Oncology (2011)
Studies With RP 56976 (Taxotere): A Semisynthetic Analogue of Taxol
Authors: I. Ringel, S. B. Horwitz
Journal: JNCI Journal of the National Cancer Institute (1991)

RP 56976 (taxotere), a new semisynthetic analogue of taxol, is a potentially important chemotherapeutic agent for the treatment of cancer. We report here that this drug is a potent inhibitor of cell replication and, like taxol, promotes the in vitro assembly of stable microtubules in the absence of guanosine triphosphate and induces microtubule-bundle formation in cells. Compared with taxol, RP 56976 is slightly more active as a promoter of tubulin polymerization. As an inhibitor of cell replication, RP 56976 is 2.5-fold more potent than taxol in J774.2 and P388 cells and at least 5-fold more potent in taxol-resistant cells.
Psychometric Findings for a Spanish Translation of the Diabetes Self-Management Profile (DSMP-Parent-Sp)
Authors: Jessica M. Valenzuela, Michelle Castro Fernandez, Olivia Hsin, Michael A. Harris, Cortney Taylor, Annette M. La Greca, Alan M. Delamater
Journal: Diabetes Care (2009)

OBJECTIVE Few validated measures exist to evaluate self-management of diabetes in families with limited English proficiency. The present study evaluated the psychometric properties and the factorial equivalence of a Spanish translation of the parent report version of the Diabetes Self-Management Profile (DSMP-Parent-Sp). RESEARCH DESIGN AND METHODS Hispanic families of youth (mean 13.7 years old) with type 1 diabetes were recruited from three clinics in South Florida and represented a wide range of nationalities and acculturation levels. A total of 127 parents reported on their child's self-management behaviors using either the original DSMP-Parent (59.8%) or the DSMP-Parent-Sp (40.2%). In addition, youth reported their self-management using the original DSMP in English, and physicians rated their perceptions of the youth's self-management. Glycemic control was indexed by A1C in the past 3 months and collected from medical chart review. RESULTS Item analysis confirmed that the DSMP-Parent-Sp items related to the overall composite score in expected ways, and internal consistency estimates were adequate. Paired correlations demonstrated strong parent-child concordance and a significant relationship with physician perceptions of self-management. Evidence of concurrent and convergent validity, as well as “strict factorial invariance,” was demonstrated. CONCLUSIONS These preliminary findings indicate that the DSMP-Parent-Sp is a reliable and valid parent report measure of the diabetes self-management behaviors of Hispanic youths. In addition, there is preliminary evidence that the translated measure may be considered equivalent to the original English measure when used to measure self-management in Hispanic youth with diabetes.
PERFORATION OF AN AORTIC ANEURYSM INTO THE SUPERIOR VENA CAVA
Authors: Albert Jackson
Journal: JAMA (1952)

Perforation of an aortic aneurysm into the superior vena cava is still a rare entity; most authors have reported one or two cases.<sup>1</sup>Although our patient came to the Veterans Administration Hospital in May, 1950, we intended to delay publication until we had an additional case to report; however, we have not seen another patient with this condition. A correct diagnosis was made during the patient's life without cardiac catheterization or angiocardiography. <h3>REPORT OF A CASE</h3> L. R. T., a 53-year-old white male veteran, was admitted to the hospital by ambulance on May 11, 1950, in a semistuporous, disoriented, and confused state. He was dyspneic and could scarcely speak, the history being taken from his wife. The patient had been a heavy equipment operator and had taken great pride in his physical strength and ability to lift heavy objects. His present illness began approximately five to six weeks prior
. . . and for Chlamydia
Authors: Joan Stephenson
Journal: JAMA (1998)

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