tbuckley/cabot-search huggingface dataset:
Leisure-Time Physical Activity Levels and Risk of Coronary Heart Disease and Death
Authors: Arthur S. Leon
Journal: JAMA (1987)

The relation of self-selected leisure-time physical activity (LTPA) to first major coronary heart disease (CHD) events and overall mortality was studied in 12 138 middle-aged men participating in the Multiple Risk Factor Intervention Trial. Total LTPA over the preceding year was quantitated in mean minutes per day at baseline by questionnaire, with subjects classified into tertiles (low, moderate, and high) based on LTPA distribution. During seven years of follow-up, moderate LTPA was associated with 63% as many fatal CHD events and sudden deaths, and 70% as many total deaths as low LTPA (<i>P</i>&lt;.01). Mortality rates with high LTPA were similar to those in moderate LTPA; however, combined fatal and nonfatal major CHD events were 20% lower with high as compared with low LTPA (<i>P</i>&lt;.05). These risk differentials persisted after statistical adjustments for possible confounding variables, including other baseline risk factors and Multiple Risk Factor Intervention Trial group assignments. It is concluded that LTPA has a modest inverse relation to CHD and overall mortality in middle-aged men at high risk for CHD. (<i>JAMA</i>1987;258:2388-2395)
Iron Fortification of Baby Foods and Sudden Infant Death
Authors: Samuel Ayres
Journal: JAMA (1973)

<h3>To the Editor.—</h3> A LETTER TO THE EDITOR on possible harmful effects of iron fortification of baby foods, by Thomas C. Washburn (224:530, 1973), did not mention one possible danger that might prove serious. D.F.L. Money, in two articles (<i>J Pediatr</i>77:165-166, 1970;<i>Br Med J</i>4:559, 1971) has called attention to the striking similarity of the sudden infant death syndrome to sudden death in certain experimental animals receiving vitamin E-deficient diets, and cites evidence that the infant deaths may also be associated with a deficiency of vitamin E or selenium or both in nonbreast fed infants. Money states that infant serum vitamin E levels are low at birth, and for those fed cow's milk the levels remain low for six to eight months. Cow's milk apparently cannot supply a theoretical infant selenium requirement in the absence of sufficient vitamin E, and the continuing simultaneous deficiency could result in peroxidation of the
Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent
Authors: Joseph Keane, Sharon Gershon, Robert P. Wise, Elizabeth Mirabile-Levens, John Kasznica, William D. Schwieterman, Jeffrey N. Siegel, M. Miles Braun
Journal: New England Journal of Medicine (2001)

Infliximab is a humanized antibody against tumor necrosis factor α (TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis. Approximately 147,000 patients throughout the world have received infliximab. Excess TNF-α in association with tuberculosis may cause weight loss and night sweats, yet in animal models it has a protective role in the host response to tuberculosis. There is no direct evidence of a protective role of TNF-α in patients with tuberculosis.
Inhaled nitric oxide therapy in adults: European expert recommendations
Authors: Peter Germann, Antonio Braschi, Giorgio Della Rocca, Anh Tuan Dinh-Xuan, Konrad Falke, Claes Frostell, Lars E. Gustafsson, Philippe Hervé, Philippe Jolliet, Udo Kaisers, Hector Litvan, Duncan J. Macrae, Marco Maggiorini, Nandor Marczin, Bernd Mueller, Didier Payen, Marco Ranucci, Dietmar Schranz, Rainer Zimmermann, Roman Ullrich
Journal: Intensive Care Medicine (2005)
Glucocorticoid and Mineralocorticoid Effects on Adrenocorticotropin and β-Endorphin in the Adrenalectomized Rat
Authors: Alan T. Lim, B. A. K. Khalid, Judith Clements, John W. Funder
Journal: Journal of Clinical Investigation (1982)

Immunoreactive ACTH (ir-ACTH) and immunoreactive β-endorphin (ir-βEP) were determined in plasma, anterior pituitary, neuro-intermediate lobe, and hypothalamus of sham-adrenalectomized rats, and adrenalectomized rats given six daily injections of vehicle (oil), dexamethasone, 9α-fluorocortisol or deoxycorticosterone. 6 d after adrenalectomy, anterior pituitary ir-ACTH and ir-βEP were double, and plasma levels approximately fivefold those in controls. Adrenalectomy did not alter hypothalamic levels of either peptide, or ir-βEP in neuro-intermediate lobe, in which tissue ir-ACTH was below detection limit at routine dilutions. Dexamethasone (0.2-200 μg/d) concurrently suppressed plasma ir-ACTH and ir-βEP, with a near maximal effect at 20 μg, and a half-maximal effect between 2 and 6 μg; similar dose-response characteristics were found for thymolysis. Step-wise increases in anterior pituitary content of both peptides were found, with no change in hypothalamic levels of either peptide, or neuro-intermediate lobe ir-βEP. 9α-fluorocortisol (0.2-200 μg/d) produced plasma, anterior pituitary, and hypothalamic effects equivalent to dexamethasone, but with one-tenth the potency. Unlike dexamethasone, higher doses of 9α-fluorocortisol significantly elevated neuro-intermediate lobe ir-βEP. Deoxycorticosterone (2-2,000 μg/d) produced no significant changes in plasma, anterior pituitary or hypothalamic levels of either peptide; like 9α-fluorocortisol, doses of >60 μg/d significantly elevated neuro-intermediate lobe ir-βEP. Whereas ir-ACTH and ir-βEP synthesis in and release from the anterior pituitary are under complex negative feedback glucocorticoid control, there exists a mineralocorticoid-specific effect on neuro-intermediate lobe content of ir-βEP.
Ultrasound validity in the measurement of knee cartilage thickness
Authors: E Naredo, C Acebes, I Moller, F Canillas, J J de Agustin, E de Miguel, E Filippucci, A Iagnocco, C Moragues, R Tuneu, J Uson, J Garrido, E Delgado-Baeza, I Saenz-Navarro
Journal: Annals of the Rheumatic Diseases (2008)

<h3>Objective:</h3> To assess the multiexaminer reproducibility and the accuracy comparing with cadaver anatomic specimens of ultrasound (US) measurement of femoral articular cartilage (FAC) thickness. <h3>Methods:</h3> In 8 flexed cadaver knees, FAC thickness was blindly, independently and consecutively measured twice by 10 rheumatologists at the lateral condyle (LC), medial condyle (MC) and intercondylar notch (IN) with US. After the US measurements, the knees were dissected. Articular cartilage integrity was evaluated macroscopically in the femoral condyles. FAC thickness was blindly measured in the specimens using a stereoscopic magnifying loupe and a digitised image software. Interexaminer and intraexaminer reliability of US FAC thickness measurement and agreement between US and anatomic measurements were assessed by estimating the intraclass correlation coefficient (ICC). <h3>Results:</h3> Interexaminer ICCs were higher than 0.90 for MC (p&lt;0.001) and IN (p&lt;0.001) and higher than 0.75 for LC (p&lt;0.01). Mean intraexaminer ICCs were 0.832 for MC (p&lt;0.001), 0.696 for LC (p&lt;0.001) and, 0.701 for IN (p&lt;0.001). Agreement between US and anatomic FAC thickness measurements was good for MC (ICC 0.719; p = 0.020) and poor for LC (p = 0.285) and IN (p = 0.332). Bland–Altman analysis showed that the difference between US and anatomic values was considerably high in the one knee with severely damaged FAC. After eliminating this knee from the analysis, ICCs were 0.883 (p&lt;0.001) for MC, 0.795 (p = 0.016) for LC and 0.732 for IN (p = 0.071). <h3>Conclusion:</h3> US demonstrated a good reproducibility in FAC thickness measurement by multiple examiners. In addition, US FAC thickness measurement was accurate in normal to moderately damaged cartilage.
Athlete's heart in women. Echocardiographic characterization of highly trained elite female athletes
Authors: A. Pelliccia
Journal: JAMA (1996)

OBJECTIVES; To define the expression of "athlete's heart" in women by determining the alterations in cardiac dimensions associated with long-term intense conditioning in elite female athletes. DESIGN; Prospective cardiovascular assessment conducted from 1986 through 1993. Subjects were evaluated using 2-dimensional, M-mode, and Doppler echo-cardiographic studies.Institute of Sports Science, Italian National Olympic Committee, Rome, Italy.A total of 600 elite female athletes (mean age, 21 years; range, 12-49 years) who had participated in vigorous training (mean duration, 9 years; range, 2-32 years) and had competed in 27 sports, including 211 athletes at the international level and 389 at the national level. A control group consisted of 65 sedentary volunteer women (mean age, 23.7 years; range, 14-41 years) who were free of cardiovascular disease and who did not participate in regular athletic training.Left ventricular end-diastolic cavity dimension and wall thickness.Athletes demonstrated larger left ventricular end-diastolic cavity dimension (mean +/- SD) (49 +/- 4 mm) and greater maximal wall thickness (8.2 +/- 0.9 mm) than controls (46 +/- 3 mm and 7.2 +/- 0.6 mm; P < .001). These dimensions were 6% and 14% larger in athletes. Among athletes, left ventricular cavity dimension was 40 mm to 66 mm, exceeded normal limits ( > 54 mm) in 47 women (8%), and was within the range consistent with primary dilated cardiomyopathy ( > or = 60 mm) in 4 athletes (1%). Training for endurance sports, such as cycling, cross-country skiing, and rowing had the greatest effect on cavity dimension. Left ventricular wall thickness was 6 mm to 12 mm in athletes and did not exceed normal limits or extend into the borderline gray zone with hypertrophic cardiomyopathy in any subject. Compared with data from 738 previously studied male athletes, female athletes showed significantly smaller left ventricular cavity dimension (11% less; P < .001) and wall thickness (23% less; P < .001).Highly trained women athletes frequently demonstrate cardiac dimensional changes as an adaptation to physical training, although absolute left ventricular cavity size exceeding normal limits was evident in a minority (8%) of women athletes and was rarely (1% of athletes) within the range of dilated cardiomyopathy. Athletic training was not a stimulus for substantial increases in absolute left ventricular wall thickness, which was within normal limits for all women athletes. These findings suggest that the clinical differentiation of athlete's heart and hypertrophic cardiomyopathy appears to be a diagnostic dilemma that is limited to male athletes.
Brain asymmetry as a potential biomarker for developmental TCDD intoxication: a dose-response study.
Authors: D S Henshel, J W Martin, J C DeWitt
Journal: Environmental Health Perspectives (1997)

Previous studies have indicated that in ovo exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds is correlated with the development of grossly asymmetric brains. This asymmetry is manifested as a difference between the two halves of the forebrain and the tecta. Previously, only wildlife species (heron, cormorant, and eagle) had been shown to manifest this response. In the wildlife studies, the frequency and degree of left-right interhemispheric differences had been correlated with the levels of polychlorinated dibenzo-p-dioxin toxic equivalency factors (TEFs) in eggs from the same nest (heron, cormorant). We studied the effect of in ovo exposure to TCDD on the brain throughout development in a sensitive laboratory model (chicken). Embryos from chicken eggs (Gallus gallus) injected with one of several doses of TCDD or vehicle control were sacrificed after 9, 11, 13, 15, 17, or 20 days of incubation, or incubated to hatch and then sacrificed either within 24 hr or at 3 weeks post-hatch. Measurements of both chicken embryo and hatchling brains indicated that 1) TCDD alone induced the brain asymmetry in developing chickens; 2) this brain asymmetry was similar to that observed in animals exposed in the wild to a mixture of TCDD-related contaminants; 3) there was a dose-related increase in both the frequency and severity of brain asymmetry observed at all ages measured; and 4) the asymmetry was measurable in embryonic brains at an age when the braincase was a thin, flexible layer (embryonic day 9), implying that the effect of TCDD was directly on the developing brain and not indirectly via an effect on the braincase.
Getting Cut: Failing to Survive Surgical Residency Training
Authors: M. Mark Hoffer
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular Mechanism of Lipopeptide Presentation by CD1a
Authors: Dirk M. Zajonc, M.D. Max Crispin, Thomas A. Bowden, David C. Young, Tan-Yun Cheng, Jingdan Hu, Catherine E. Costello, Pauline M. Rudd, Raymond A. Dwek, Marvin J. Miller, Michael B. Brenner, D. Branch Moody, Ian A. Wilson
Journal: Immunity (2005)
Estrogen receptor α (ERα) expression in neuronal cells affects bone mass
Authors: M K Lagerquist, C Engdahl, A E Börjesson, S H Windahl, E Studer, L Westberg, E Eriksson, A Koskela, J Tuukkanen, A Krust, P Chambon, H Carlsten, C Ohlsson
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background and objective</h3> Bone mass is often negatively affected in autoimmune diseases such as rheumatoid arthritis. It has generally been assumed that bone mass is controlled by endocrine mechanisms and/or the local bone environment. Recent findings demonstrate that central pathways are involved in the regulation of bone mass. Estrogen is involved in the regulation of bone mass and the central nervous system is also a target for estrogen actions. The aim of this study was to investigate in vivo the role of central estrogen receptor-α (ERα) expression for bone mass. <h3>Methods</h3> Nestin-Cre mice were crossed with ERα<sup>flox</sup> mice to generate mice lacking ERα expression specifically in nervous tissue (nestin-ERα<sup>−/−</sup>). Mice homozygous for ERα-loxP, but lacking Cre expression, were used as controls. Phenotyping of the bone was performed using pQCT, µCT, histomorphometry and three-point bending. Gene expression analyses were performed using real-time PCR and serum analyses with commercial kits. <h3>Results</h3> Bone mineral density was increased in both the trabecular and cortical bone compartments in nestin-ERα<sup>−/−</sup> mice compared to controls. Femoral bone strength was increased in nestin-ERα<sup>−/−</sup> mice as demonstrated by increased stiffness and maximal load of failure. The high bone mass phenotype in nestin-ERα<sup>−/−</sup> mice was mainly caused by increased bone formation. Serum leptin levels were elevated as a result of increased leptin expression in white adipose tissue (WAT) and slightly increased amount of WAT in nestin-ERα<sup>−/−</sup> mice. Leptin receptor mRNA levels were reduced in the hypothalamus but not in bone. Furthermore, nestin-ERα<sup>−/−</sup> mice displayed disturbed regulation of T cells with reduced proliferation and decreased frequency in bone marrow. <h3>Conclusions</h3> In summary, while peripheral ERα activation increases bone mass, the authors here demonstrate that central ERα activation decreases bone mass. Thus, the balance between peripheral stimulatory and central inhibitory ERα actions is important in the regulation of bone mass. The authors propose that the increased bone mass in nestin-ERα<sup>−/−</sup> mice is mediated via decreased central leptin sensitivity and thereby increased secretion of leptin from WAT which, in turn, results in increased peripheral leptin-induced bone formation. In addition, an altered T cell regulation might contribute to the high bone mass phenotype in the nestin-ERα<sup>−/−</sup> mice.
The Psychological Panel in Diagnosis and Prognosis*
Authors: WALTER FREEMAN
Journal: Annals of Internal Medicine (1930)

Article1 July 1930The Psychological Panel in Diagnosis and PrognosisCorrelation of Personality Type With Susceptibility to Disease, Based upon 1400 Necropsies.WALTER FREEMAN, M.D., F.A.C.P.WALTER FREEMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-1-29 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo know an organ and its diseases thoroughly is the apparent goal of many medical and surgical specialists, but to know the patient thoroughly is the goal that should be set for himself by the true physician. All the great teachers have emphasized this, cautioning their students against too narrow a point of view. Nevertheless it is only with experience and practice, backed up by humanism, that the view can be broadened, since the intensive study of a particular disease or system of organs leads to the neglect of the larger aspects of the case and of the individual in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Read at the Minneapolis Meeting of the American College of Physicians, February 10, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPERSONALITY AND THE ENDOCRINES; A STUDY BASED UPON 1400 QUANTITATIVE NECROPSIES*WALTER FREEMAN, M.D., F.A.C.P.HUMAN CONSTITUTION: A STUDY OF THE CORRELATIONS BETWEEN PHYSICAL ASPECTS OF THE BODY AND SUSCEPTIBILITY TO CERTAIN DISEASES*WALTER FREEMAN, M.D., F.A.C.P. 1 July 1930Volume 4, Issue 1Page: 29-38KeywordsSystemic diseases Issue Published: 1 July 1930 PDF downloadLoading ...
Frontal and Sagittal Electrocardiograms of Normal and Hypertensive Subjects during an Experimentally Produced Phase of Lowered Blood Pressure
Authors: JOSEPH BRUMLÍK, CHARLES E. KOSSMANN
Journal: Circulation (1952)

Reduction of the blood pressure in normal and hypertensive subjects by intravenous pyrogen caused the electrocardiograms to assume a more abnormal configuration as judged by present criteria of electrocardiographic normality. A temporary reduction of the blood pressure by the intravenous administration of tetraethylammonium chloride caused only minor and variable modifications of the electrocardiogram. The results of the experiments as done do not support the concept of strain as applied to certain electrocardiographic abnormalities which occur in the course of hypertension.
Tea catechins improve left ventricular dysfunction, suppress myocardial inflammation and fibrosis, and alter cytokine expression in rat autoimmune myocarditis
Authors: Jun‐ichi Suzuki, Masahito Ogawa, Hideki Futamatsu, Hisanori Kosuge, Yuko M. Sagesaka, Mitsuaki Isobe
Journal: European Journal of Heart Failure (2006)
Gastrointestinal disease: Pathophysiology/diag-nosis/management. 5th Edition. Edited by M. H. Sleisenger and J. S. Fordtran and Associate Editors B. F. Scharschmidt and M. Feldman, 2445 pp. Philadelphia: W.B. Saunders, 1993. $185
Authors: Raymond S. Koff
Journal: Hepatology (1994)
Eine häufig vorkommende Lösung des Oedipuskonfliktes
Authors: R. Le Coultre
Journal: Psychotherapy and Psychosomatics (1956)

Research Articles| February 10 2010 Eine häufig vorkommende Lösung des Oedipuskonfliktes Subject Area: Psychiatry and Psychology R. Le Coultre R. Le Coultre Amsterdam Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1956) 4 (4): 289–296. https://doi.org/10.1159/000285256 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation R. Le Coultre; Eine häufig vorkommende Lösung des Oedipuskonfliktes. Acta Psychotherapeutica et Psychosomatica 1 April 1956; 4 (4): 289–296. https://doi.org/10.1159/000285256 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1956Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Interferon Beta and Long-term Disability in Multiple Sclerosis—Reply
Authors: Benjamin M. Greenberg, Elliot Frohman
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal