Association of High Serum Ferritin Concentration with Glucose Intolerance and Insulin Resistance in Healthy People
Authors: Michael Haap, Andreas Fritsche, Heinz Joachim Mensing, Hans-Ulrich Hring, Michael Stumvoll
Journal: Annals of Internal Medicine (2003)

Letters18 November 2003Association of High Serum Ferritin Concentration with Glucose Intolerance and Insulin Resistance in Healthy PeopleMichael Haap, MD, Andreas Fritsche, MD, Heinz Joachim Mensing, MD, Hans-Ulrich Hring, MD, and Michael Stumvoll, MDMichael Haap, MDFrom University of Tbingen; D-72076 Tbingen, Germany., Andreas Fritsche, MDFrom University of Tbingen; D-72076 Tbingen, Germany., Heinz Joachim Mensing, MDFrom University of Tbingen; D-72076 Tbingen, Germany., Hans-Ulrich Hring, MDFrom University of Tbingen; D-72076 Tbingen, Germany., and Michael Stumvoll, MDFrom University of Tbingen; D-72076 Tbingen, Germany.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-10-200311180-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Increasing evidence points to an association between increased body iron storage and type 2 diabetes mellitus, even outside the context of hemochromatosis (1, 2). A small intervention study provided preliminary evidence that bloodletting, which resulted in 50% reduction of serum ferritin concentrations, improved glycemia and insulin sensitivity in patients with type 2 diabetes (3). However, interpretation of mechanistic studies in patients with overt type 2 diabetes mellitus are complicated because glycemic control itself influences serum ferritin concentrations (glycosylated ferritin has a longer serum half-life) and primary effects on insulin sensitivity or -cell function can no longer ...References1. Tuomainen TP, Nyyssonen K, Salonen R, Tervahauta A, Korpela H, Lakka T, . Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men. Diabetes Care. 1997;20:426-8. [PMID: 9051399] CrossrefMedlineGoogle Scholar2. Ford ES, Cogswell ME. Diabetes and serum ferritin concentration among U.S. adults. Diabetes Care. 1999;22:1978-83. [PMID: 10587829] CrossrefMedlineGoogle Scholar3. Fernandez-Real JM, Penarroja G, Castro A, Garcia-Bragado F, Hernandez-Aguado I, Ricart W. Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and -cell function. Diabetes. 2002;51:1000-4. [PMID: 11916918] CrossrefMedlineGoogle Scholar4. Ferrannini E. Insulin resistance, iron, and the liver. Lancet. 2000;355:2181-2. [PMID: 10881887] CrossrefMedlineGoogle Scholar5. Qian M, Liu M, Eaton JW. Transition metals bind to glycated proteins forming redox active glycochelates: implications for the pathogenesis of certain diabetic complications. Biochem Biophys Res Commun. 1998;250:385-9. [PMID: 9753639] CrossrefMedlineGoogle Scholar6. Fernandez-Real JM, Lopez-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes. 2002;51:2348-54. [PMID: 12145144] CrossrefMedlineGoogle Scholar7. Resnick HE, Howard BV. Diabetes and cardiovascular disease. Annu Rev Med. 2002;53:245-67. [PMID: 11818473] CrossrefMedlineGoogle Scholar8. Hua NW, Stoohs RA, Facchini FS. Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians. Br J Nutr. 2001;86:515-9. [PMID: 11591239] CrossrefMedlineGoogle Scholar9. Kato I, Dnistrian AM, Schwartz M, Toniolo P, Koenig K, Shore RE, . Risk of iron overload among middle-aged women. Int J Vitam Nutr Res. 2000;70:119-25. [PMID: 10883405] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Tbingen; D-72076 Tbingen, Germany.Grant Support: In part by grants from the Deutsche Forschungsgemeinschaft DFG (Stu 192/3-1 and FR 1561/1-1) and the European Union (QLRT-1999-00674). 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