tbuckley/cabot-search huggingface dataset:
Action spectra of topical psoralens: a re-evaluation
Authors: DEREK J. CRIPPS, NICHOLAS J. LOWB, AARON B. LHRNER
Journal: British Journal of Dermatology (1982)

The action spectra for producing minimal phototoxic erythema with topical 0 1% trimethyl psoralen (TMP) and 8‐mcthoxypsoralen (8‐MOP) were determined with a double monochromator in the range of 295–380 nm. Both psoralens induced photosensitivity in the range of 313–365 nm; TMP was 54% more effective than 8‐MOP. There was no difference in the dose needed to produce minimal UV erythema or phototoxic erythema with 8‐MOP and TMP at 295 and 305 nm, but at 313 nm with 8‐MOP, photosensitivity was enhanced 3.5 times, and with TMP, sensitivity was enhanced 55 times. The peak sensitivity with 8‐MOP was at 330 nm and for TMP it was 335 nm. No photosensitivity occurred above 380 nm. Results suggest that TMP and 8‐MOP are significantly photoreactive at 320–335 nm. Commonly used UV‐A light sources show peak emission around 360 nm. If there is a relationship between development of erythema and therapeutic effectiveness then this raises the possibility of alternative UV light sources for phototherapy with psoralens.
Phenotypic Features of Crohn's Disease Associated With Failure of Medical Treatment
Authors: Gordon W Moran, Marie-France Dubeau, Gilaad G Kaplan, Hong Yang, Cynthia H Seow, Richard N Fedorak, Levinus A Dieleman, Herman W Barkema, Subrata Ghosh, Remo Panaccione
Journal: Clinical Gastroenterology and Hepatology (2013)
TREATMENT OF MIDDLE-EAR SUPPURATION
Authors: H. B. Shaheen
Journal: BMJ (1929)

DISEASIES of the middle ear, whether of the d-y or suppura- tive tvpe, tend to run a chronic coutrse unless they are dealt withi plomptly and energetically.Adequiate treat- meant can be ensured only if the patient is seeni regularly; but in hospital practice, where patients are drawn from the working classes, one often finds that *the patient's regular attendance can be secured only at tthe risk of llis losinlg llis work.Dry conditions of the miiiddle ear wlhichl have failed to derive benefit from catheterization and' m-assage frequently respo-nd to treatment by intravenous injection of colloid iodi-ne; suppurative otitis media is, however, a far more seriious and dangerous type of.disease, and failure to treat it adequately has undoubtedly been responsible for a large number of operations on the teinporal bone.
Ectopic Pregnancy Occurring in the Right Inguinal Canal
Authors: Alexander A. Levi
Journal: New England Journal of Medicine (1953)

THE purpose of this paper is to present a case of pregnancy occurring in the right inguinal canal, between the layers of the abdominal wall. A careful survey of the medical literature failed to reveal any similar case; the review included a number of the current textbooks on obstetrics and gynecology. Curtis1 states that "The incidence of extrauterine gestation is estimated by Schumann as one in 300 pregnancies." He also lists 19 authors at the end of his chapter on ectopic pregnancy, none of whom describe a case similar to that reported below. Eastman,2 in discussing a rare type of . . .
The primary immune response of patients with different stages of squamous-cell bronchial carcinoma.
Authors: H M Jansen, T H The, G C de Gast, M T Esselink, G Pastoor, N G Orie
Journal: Thorax (1978)

Using the indirect ELISA technique, the IgM, IgG, and IgA antibody response to the primary test immunogen Helix pomatia haemocyanin (HPH) was studied in 30 patients with various clinical stages of primary squamous-cell bronchial carcinoma and compared with values obtained in 15 controls matched for sex, age, smoking habit, and presence of chronic bronchitis. Patients with disseminated disease (stage III) showed a significant decrease in IgG and IgA antibody response (P less than 0.001), but IgM antibodies were relatively high and not different from the controls. Although normal IgG and IgA antibody titres were found at the peak response two weeks after immunisation in patients with localised disease (stage I), these antibody titres showed a significantly more rapid decline after serial investigations at eight and 14 weeks after immunisation compared with the controls (P less than 0.001) despite total removal of the tumour burden at c four weeks after immunisation. In-vitro HPH-induced lymphocyte transformation was considerably decreased in state I patients (P less than 0.01) as well as in stage III patients (P less than 0.001). The results suggest that patients with squamous-cell bronchial carcinoma develop impaired T-cell function, which gives rise to a defective antibody response and in-vitro lymphocyte reactivity to the T-cell dependent primary immunogen HPH.
"PROPHYLAXIS OF ROENTGEN-RAY OVERDOSAGE"
Authors: Harold Swanberg
Journal: JAMA (1924)

To the Editor:  —InThe Journal, November 8, I note a short article by Dr. R. H. Rulison on this subject, reporting a case of senile keratosis of the face suggesting malignant degeneration which he treated by giving a dose of roentgen ray with the following setting: 8 inch spark gap, 5 milliamperes of current, 10 inch distance and 3.9 minutes of time. He states that he made a mistake and omitted the filter, and that the total skin dose that he administered was 4⅓ skin units, which, he says, was sufficient to cause a severe burn of the skin when passing through a 1 inch opening in a lead screen. He then goes on to state that by the use of the Kromayer lamp in this case, giving treatment every day or so for about two weeks after the above dose had been given, he was able to prevent
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
Authors: Thomas Jamieson, Mairi Clarke, Colin W. Steele, Michael S. Samuel, Jens Neumann, Andreas Jung, David Huels, Michael F. Olson, Sudipto Das, Robert J.B. Nibbs, Owen J. Sansom
Journal: Journal of Clinical Investigation (2012)

The chemokine receptor CXCR2 is a key mediator of neutrophil migration that also plays a role in tumor development. However, CXCR2 influences tumors through multiple mechanisms and might promote or inhibit tumor development depending on context. Here, we used several mouse models of spontaneous and inflammation-driven neoplasia to define indispensable roles for CXCR2 in benign and malignant tumors. CXCR2-activating chemokines were part of the secretome of cultured primary benign intestinal adenomas (ApcMin/+) and highly expressed by all tumors in all models. CXCR2 deficiency profoundly suppressed inflammation-driven tumorigenesis in skin and intestine as well as spontaneous adenocarcinoma formation in a model of invasive intestinal adenocarcinoma (AhCreER;Apcfl/+;Ptenfl/fl mice). Pepducin-mediated CXCR2 inhibition reduced tumorigenesis in ApcMin/+ mice. Ly6G+ neutrophils were the dominant source of CXCR2 in blood, and CXCR2 deficiency attenuated neutrophil recruitment. Moreover, systemic Ly6G+ cell depletion purged CXCR2-dependent tumor-associated leukocytes, suppressed established skin tumor growth and colitis-associated tumorigenesis, and reduced ApcMin/+ adenoma formation. CXCR2 is thus a potent protumorigenic chemokine receptor that directs recruitment of tumor-promoting leukocytes into tissues during tumor-inducing and tumor-driven inflammation. Similar leukocyte populations were also found in human intestinal adenomas, which suggests that CXCR2 antagonists may have therapeutic and prophylactic potential in the treatment of cancer.
Is melatonin useful in alopecia: critical appraisal of a randomized trial?
Authors: M.J. Sladden, P.E. Hutchinson
Journal: British Journal of Dermatology (2005)

Journal Article Is melatonin useful in alopecia: critical appraisal of a randomized trial? Get access M.J. Sladden, M.J. Sladden Department of Dermatology, Leicester Royal Infirmary, Leicester, U.K M.J. Sladden. E‐mail: m.sladden@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar P.E. Hutchinson P.E. Hutchinson Department of Dermatology, Leicester Royal Infirmary, Leicester, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 4, 1 October 2005, Pages 859–860, https://doi.org/10.1111/j.1365-2133.2005.06859.x Published: 01 October 2005
C-Terminal Provasopressin (Copeptin) as a Novel and Prognostic Marker in Acute Myocardial Infarction
Authors: Sohail Q. Khan, Onkar S. Dhillon, Russell J. O’Brien, Joachim Struck, Paulene A. Quinn, Nils G. Morgenthaler, Iain B. Squire, Joan E. Davies, Andreas Bergmann, Leong L. Ng
Journal: Circulation (2007)

The role of the vasopressin system after acute myocardial infarction is unclear. Copeptin, the C-terminal part of the vasopressin prohormone, is secreted stoichiometrically with vasopressin. We compared the prognostic value of copeptin and an established marker, N-terminal pro-B-type natriuretic peptide (NTproBNP), after acute myocardial infarction.In this prospective single-hospital study, we recruited 980 consecutive post-acute myocardial infarction patients (718 men, median [range] age 66 [24 to 95] years), with follow-up over 342 (range 0 to 764) days. Plasma copeptin was highest on admission (n=132, P<0.001, day 1 versus days 2 to 5) and reached a plateau at days 3 to 5. In the 980 patients, copeptin (measured at days 3 to 5) was elevated in patients who died (n=101) or were readmitted with heart failure (n=49) compared with survivors (median [range] 18.5 [0.6 to 441.0] versus 6.5 [0.3 to 267.0] pmol/L, P<0.0005). With logistic regression analysis, copeptin (odds ratio, 4.14, P<0.0005) and NTproBNP (odds ratio, 2.26, P<0.003) were significant independent predictors of death or heart failure at 60 days. The area under the receiver operating characteristic curves for copeptin (0.75) and NTproBNP (0.76) were similar. The logistic model with both markers yielded a larger area under the curve (0.84) than for NTproBNP (P<0.013) or copeptin (P<0.003) alone, respectively. Cox modeling predicted death or heart failure with both biomarkers (log copeptin [hazard ratio, 2.33], log NTproBNP [hazard ratio, 2.70]). In patients stratified by NTproBNP (above the median of approximately 900 pmol/L), copeptin above the median (approximately 7 pmol/L) was associated with poorer outcome (P<0.0005). Findings were similar for death and heart failure as individual end points.The vasopressin system is activated after acute myocardial infarction. Copeptin may predict adverse outcome, especially in those with an elevated NTproBNP (more than approximately 900 pmol/L).
144 A model to predict one year graft failure in patients transplanted for HCV cirrhosis
Authors: S. Iacob, S. Beckebaum, R. Iacob, V. Cicinnati, C. Klein, L. Gheorghe, C. Gheorghe, I. Popescu, A. Frilling, M. Malago, G. Gerken, C. Broelsch
Journal: Journal of Hepatology (2006)
Coronary Embolization of an Intramyocardial Hematoma After Myocardial Infarction
Authors: R.P. Martins, N. Coquerel, A. Zabalawi, A.-E. Baruteau, J.Y. Gauvrit, D. Boulmier, J.C. Daubert, P. Mabo, E. Donal
Journal: Circulation (2010)
Reviews and Notes: Neurology: Metabolic Brain Dysfunction in Systemic Disorders
Authors: Elliott L. Mancall
Journal: Annals of Internal Medicine (1994)

Literature of Medicine15 January 1994Reviews and Notes: Neurology: Metabolic Brain Dysfunction in Systemic DisordersElliott L. Mancall, MDElliott L. Mancall, MDHahnemann University Hospital, Philadelphia, PA 19102.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-2-199401150-00043 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Metabolic Brain Dysfunction in Systemic DisordersAllen I. Arieff and Robert C. Griggs; eds. 477 pages. Boston: Little, Brown; 1992. $126.50.The information necessary to deal effectively with neurologic diseases all too often appears forbidding, if not inaccessible, to physicians who are not neurologists. Nonetheless, neurologic disorders do represent a significant portion of disorders encountered by any general physician. Cerebral disorders that are metabolic in origin are frequently encountered in a hospital setting and often reflect systemic disease in which the brain participates as but one of several organ systems. The past two decades have seen remarkable strides in our ... Author, Article, and Disclosure InformationAffiliations: Hahnemann University Hospital, Philadelphia, PA 19102. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1994Volume 120, Issue 2Page: 176KeywordsBrainCarbohydrate metabolismClinical laboratoriesHypoxiaMyelopathyNeurologyPathogenesisRenal failureResearch laboratoriesSystemic diseases ePublished: 15 August 2000 Issue Published: 15 January 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Jordi Casals-Ariet
Authors: Jeanne Lenzer
Journal: BMJ (2004)

Epidemiologist who discovered the Lassa fever virus-and nearly died from it Jordi Casals-Ariet, an epidemiologist and virologist, was hailed by scientists around the world when he discovered the virus that causes Lassa fever.He was nearly killed by the disease in 1969 while working with the virus in his Yale laboratory.In a high-stakes gamble and with no known treatment, his doctors decided to transfuse him with blood from a nurse who had survived Lassa fever.The blood saved his life.But colleagues say that Dr Casals' contributions are far greater than his discovery of the Lassa fever virus."He did a yeoman's work in establishing useful methods of classifying viruses," said Dr Gregory Tignor, professor emeritus at Yale, who worked with Dr Casals.Little was known about many viruses when Dr Casals started his work at Yale. "Everybody has forgotten how bad it was back then," said Dr Tignor."People didn't know what was causing encephalitis.We had no way of telling the difference between rabies encephalitis, polio encephalitis, or other causes of encephalitis.But Jordi found ways, using antigens and antibodies, to figure it out.His work was so meticulous that to this day nobody has changed his classifications because they have all held up."
New HIV infections fall by a sixth in a decade
Authors: J. Zarocostas
Journal: BMJ (2010)

From 1999 to 2009 the number of new infections of HIV fell worldwide by 16%, says a report by UNAIDS, the joint United Nations agency on HIV and AIDS. Greater use of effective antiretrovirals has also resulted in fewer AIDS related deaths, it says.

The fall in new infections between 2001 and 2009 exceeded 25% in 33 countries, including 22 in sub-Saharan Africa, says the report. However, in seven countries—five in eastern Europe and central Asia—the incidence of HIV rose by more than 25% in the same period.

Michel Sidibe, executive director of UNAIDS, said, “We are breaking the trajectory of the AIDS epidemic with bold actions and …
FIRST USE OF POLYGRAPH AND SPHYGMOGRAPH
Authors: Russell Burton-Opitz
Journal: JAMA (1925)

<h3>To the Editor:</h3> —I am glad that Dr. Fossier has called attention to the error regarding the discovery of the polygraph. While the simple tambours were first employed by Vierordt in 1855, Marey first used the multiple tambour. Long before the time of Mackenzie, an instrument of this type was used by Hürthle. In 1898, when I first worked in Hürthle's laboratory, I attempted to obtain differences in the time relationship of the cardiac impulse and the carotid and radial pulses. This required the simultaneous working of three receiving and three recording tambours, the latter registering their excursions on the smoked paper of the kymograph above the second markings of a chronograph. Thus, the only difference between this early method of registration by means of multiple tambours and that of Mackenzie is that the various appliances were fastened to a small drum, which could be conveniently moved from place to
General practice's last stand
Authors: D P Kernick
Journal: BMJ (1995)

Adiscussion document from the BMA's General Medical Services Committee, which was circulated in July, defines the core content of general practice. The intention is to ensure that all general practitioners provide a basic standard of service and are able to choose which non-core services are provided at an appropriate level of additional remuneration. Future social historians will identify this document as a milestone in our professional decline. Not unlike General Custer a hundred years ago, it is general practice's last stand—heroic, futile, misconceived, and with the same inevitable conclusion.

The paper suggests that our core professional area is to respond to the “timeless human need” of managing real and perceived illness. “This aspect of human behaviour transcends history, geography and culture and will survive the ephemeral health policies of transient governments.” Unfortunately, this superficial use of metaphor fails to appreciate the real world as it analyses our “sovereign professional territory.” The government is not transient but a permanent phenomenon in that its actions reflect changes in society, both economic and sociological.

This naive use of metaphor is again shown by one of the …
&lt;emph type="ital"&gt;The Legend of John Brown&lt;/emph&gt;
Authors: Thomas B. Cole
Journal: JAMA (2010)

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US judge bans use of term “light cigarette” worldwide
Authors: Anne Harding
Journal: BMJ (2007)

UK NEWS UK Biobank gets 10% response rate as it starts recruiting volunteers, p659 World NEWS US �u�ge bans use o�� ter�� �lig�t cigarette�� �orl��i�e, p65� US �u�ge bans use o�� ter�� �lig�t cigarette�� �orl��i�e
IgG glycan hydrolysis by EndoS diminishes the pro-inflammatory properties of immune complexes from patients with SLE – a possible new treatment?
Authors: Christian Lood, Maria Allhorn, Rolf Lood, Birgitta Gullstrand, Anders I Olin, Lars Rönnblom, Gunnar Sturfelt, Lennart Truedsson, Mattias Collin, Anders A Bengtsson
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background and objectives</h3> Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in several organ systems, related to the presence of circulating and tissue-deposited immune complexes (ICs) which stimulate leucocytes through FcγRs with subsequent inflammation. Treatment with EndoS, an IgG glycan hydrolysing bacterial enzyme from <i>Streptococcus pyogenes,</i> has shown beneficial effects in several experimental animal models of chronic inflammatory disease. In the present study the authors asked if EndoS could affect pro-inflammatory properties of ICs and have the potential to be developed as a therapy in SLE. <h3>Materials and methods</h3> ICs, purified from SLE patients or RNA-containing ICs formed in vitro, were treated with EndoS and used in several assays reflecting different important parts of SLE pathogenesis such as phagocytosis by polymorphonuclear neutrophils (PMNs) and plasmacytoid dendritic cells (pDCs), complement activation and IFNα production by pDCs. <h3>Results</h3> Our results demonstrate that EndoS treatment could abolish all pro-inflammatory properties of ICs investigated. This includes FcγR-mediated phagocytosis by pDCs (p&lt;0.0001) and subsequent production of IFNα (p&lt;0.0001), IC-induced classical complement pathway activation (p&lt;0.0001), chemotaxis and oxidative burst activity of PMNs (p=0.002). The authors could also demonstrate direct effects on the molecular structure of ICs after EndoS treatment with decreased size and glycosylation patterns. <h3>Conclusions</h3> Prominent effects of EndoS treatment were seen in several pathogenetically important IC-mediated events and our data suggest that EndoS have the potential to be developed as a novel therapy in SLE.
Cardiac Sodium Channel Na <sub>v</sub> 1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin
Authors: Bruno Gavillet, Jean-Sébastien Rougier, Andrea A. Domenighetti, Romina Behar, Christophe Boixel, Patrick Ruchat, Hans-Anton Lehr, Thierry Pedrazzini, Hugues Abriel
Journal: Circulation Research (2006)

The cardiac sodium channel Na(v)1.5 plays a key role in cardiac excitability and conduction. The purpose of this study was to elucidate the role of the PDZ domain-binding motif formed by the last three residues (Ser-Ile-Val) of the Na(v)1.5 C-terminus. Pull-down experiments were performed using Na(v)1.5 C-terminus fusion proteins and human or mouse heart protein extracts, combined with mass spectrometry analysis. These experiments revealed that the C-terminus associates with dystrophin, and that this interaction was mediated by alpha- and beta-syntrophin proteins. Truncation of the PDZ domain-binding motif abolished the interaction. We used dystrophin-deficient mdx(5cv) mice to study the role of this protein complex in Na(v)1.5 function. Western blot experiments revealed a 50% decrease in the Na(v)1.5 protein levels in mdx(5cv) hearts, whereas Na(v)1.5 mRNA levels were unchanged. Patch-clamp experiments showed a 29% decrease of sodium current in isolated mdx(5cv) cardiomyocytes. Finally, ECG measurements of the mdx(5cv) mice exhibited a 19% reduction in the P wave amplitude, and an 18% increase of the QRS complex duration, compared with controls. These results indicate that the dystrophin protein complex is required for the proper expression and function of Na(v)1.5. In the absence of dystrophin, decreased sodium current may explain the alterations in cardiac conduction observed in patients with dystrophinopathies.
Folliculotropic mycosis fungoides (stage IIA) progressing to Sézary syndrome: a case report
Authors: N. Agar, S.J. Whittaker
Journal: British Journal of Dermatology (2008)

Journal Article Folliculotropic mycosis fungoides (stage IIA) progressing to Sézary syndrome: a case report Get access N. Agar, N. Agar St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Rd SE1 7EH, London, U.K. Correspondence: N. Agar. E‐mail: nita_agar@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar S.J. Whittaker S.J. Whittaker St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Rd SE1 7EH, London, U.K. Correspondence: S.J. Whittaker. E‐mail: Sean.Whittaker@kcl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 5, 1 November 2008, Pages 1197–1199, https://doi.org/10.1111/j.1365-2133.2008.08802.x Published: 01 November 2008
Roles of endogenous monocyte chemoattractant protein-1 in ischemia-induced neovascularization
Authors: Hiroshi Niiyama, Hisashi Kai, Tomoka Yamamoto, Toshifumi Shimada, Ken-Ichiro Sasaki, Toyoaki Murohara, Kensuke Egashira, Tsutomu Imaizumi
Journal: Journal of the American College of Cardiology (2004)