Association between Protein Levels and Mortality in Patients with Peripheral Arterial Disease
Authors: Mary M. McDermott, Lu Tian, Kiang Liu
Journal: Annals of Internal Medicine (2008)

Letters1 July 2008Association between Protein Levels and Mortality in Patients with Peripheral Arterial DiseaseMary M. McDermott, MD, Lu Tian, ScD, and Kiang Liu, PhDMary M. McDermott, MDFrom Northwestern University, Chicago, IL 60611.Search for more papers by this author, Lu Tian, ScDFrom Northwestern University, Chicago, IL 60611.Search for more papers by this author, and Kiang Liu, PhDFrom Northwestern University, Chicago, IL 60611.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-1-200807010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:First, because of relatively limited statistical power, we restricted the number of covariates included in our statistical models. Covariates in our fully adjusted models were selected a priori on the basis of previously published work that identified these covariates as potential confounders of the association of biomarkers with mortality. For example, previous studies demonstrate that the ankle–brachial index and black race are each associated with increased mortality among persons with PAD (1, 2), even though these characteristics were not statistically significantly associated with mortality in univariate analyses in our study. Nonetheless, we agree with Dr. Fujita that statistical ...References1. Feringa HH, Bax JJ, Hoeks S, van Waning VH, Elhendy A, Karagiannis S, et al. A prognostic risk index for long-term mortality in patients with peripheral arterial disease. Arch Intern Med. 2007;167:2482-9. [PMID: 18071171] CrossrefMedlineGoogle Scholar2. Garg PK, Tian L, Criqui MH, Liu K, Ferrucci L, Guralnik JM, et al. Physical activity during daily life and mortality in patients with peripheral arterial disease. Circulation. 2006;114:242-8. [PMID: 16818814] CrossrefMedlineGoogle Scholar3. Lloyd-Jones DM, Liu K, Tian L, Greenland P. Narrative review: Assessment of C-reactive protein in risk prediction for cardiovascular disease. Ann Intern Med. 2006;145:35-42. [PMID: 16818927] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Northwestern University, Chicago, IL 60611.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNarrative Review: Assessment of C-Reactive Protein in Risk Prediction for Cardiovascular Disease Donald M. Lloyd-Jones , Kiang Liu , Lu Tian , and Philip Greenland Biomarkers of Inflammation and Thrombosis as Predictors of Near-Term Mortality in Patients with Peripheral Arterial Disease: A Cohort Study Himabindu Vidula , Lu Tian , Kiang Liu , Michael H. Criqui , Luigi Ferrucci , William H. Pearce , Philip Greenland , David Green , Jin Tan , Daniel B. Garside , Jack Guralnik , Paul M Ridker , Nader Rifai , and Mary M. McDermott Association between Protein Levels and Mortality in Patients with Peripheral Arterial Disease Tetsuji Fujita Metrics 1 July 2008Volume 149, Issue 1Page: 64-65KeywordsC-reactive proteinsCardiovascular disease riskCardiovascular diseasesCholesterolMedical risk factorsPeripheral vascular diseaseStatistical models ePublished: 1 July 2008 Issue Published: 1 July 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...