Insulin-like Activity in Insulin-treated Patients with Diabetes Mellitus
Authors: GERALD REAVEN
Journal: Annals of Internal Medicine (1964)

Article1 October 1964Insulin-like Activity in Insulin-treated Patients with Diabetes MellitusGERALD REAVEN, M.D., LESTER SALANS, M.D.GERALD REAVEN, M.D.Search for more papers by this author, LESTER SALANS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-680 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough treatment of diabetic patients with insulin has resulted in satisfactory control of hyperglycemia, its use has not significantly affected the incidence of diabetic retinopathy, neuropathy, nephropathy, or premature atherosclerosis. Indeed, the apparent increase in these manifestations of what might be referred to as the chronic diabetic syndrome would seem to raise the logical alternative that insulin is somehow involved in the genesis of these lesions. This possibility has been discarded in the past, primarily because all clinical manifestations of the chronic diabetic syndrome have been described in patients who never received insulin. This objection becomes less meaningful with recent...References1. YALOWBERSON RSSA: Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 39: 1157, 1960. CrossrefMedlineGoogle Scholar2. STEINKECAMERINIMARBLERENOLD JRAAE: Elevated levels of serum insulin-like activity as measured with adipose tissue in early untreated diabetes and prediabetes. Metabolism 10: 707, 1961. MedlineGoogle Scholar3. VALLANCE-OWENHURLOCKPLEASE JBNW: Plasma insulin-activity in diabetes mellitus. Lancet 2: 583, 1955. CrossrefGoogle Scholar4. MARTINRENOLDDAGENAIS DBAEYM: An assay for insulin-like activity using rat adipose tissue. Lancet 2: 76, 1958. CrossrefMedlineGoogle Scholar5. SNIDERGODFREY FP: Collecting C14O2 in a Warburg flask for subsequent scintillation counting. J. Lipid Res. 2: 195, 1961. 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Author, Article, and Disclosure InformationAffiliations: Palo Alto, CaliforniaFrom the Department of Medicine, Stanford University School of Medicine, Palo Alto, Calif.This investigation was supported by fellowship 2-F2-AM-20, 076 from the National Institute of Arthritis and Metabolic Diseases, U. S. Public Health Service, Bethesda, Md., and a research grant from the San Mateo County (Calif.) Heart Association.Requests for reprints should be addressed to Gerald Reaven, M.D., Metabolic Research Unit, Stanford Medical Center, 300 Pasteur Drive, Palo Alto, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGerald M. 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WILLIAMS, M.D., F.A.C.P.ATHEROMA, GLUCOSE, LIPID, AND INSULIN 1 October 1964Volume 61, Issue 4Page: 680-687KeywordsFellowshipsHeart diseasesHyperglycemiaInsulinLesionsMedical servicesMetabolic disordersNeuropathyPatientsResearch grants Issue Published: 1 October 1964 PDF DownloadLoading ...