tbuckley/cabot-search huggingface dataset:
The potential health impacts of climate variability and change for the United States: executive summary of the report of the health sector of the U.S. National Assessment.
Authors: J A Patz, M A McGeehin, S M Bernard, K L Ebi, P R Epstein, A Grambsch, D J Gubler, P Reither, I Romieu, J B Rose, J M Samet, J Trtanj
Journal: Environmental Health Perspectives (2000)

We examined the potential impacts of climate variability and change on human health as part of a congressionally mandated study of climate change in the United States. Our author team, comprising experts from academia, government, and the private sector, was selected by the federal interagency U.S. Global Change Research Program, and this report stems from our first 18 months of work. For this assessment we used a set of assumptions and/or projections of future climates developed for all participants in the National Assessment of the Potential Consequences of Climate Variability and Change. We identified five categories of health outcomes that are most likely to be affected by climate change because they are associated with weather and/or climate variables: temperature-related morbidity and mortality; health effects of extreme weather events (storms, tornadoes, hurricanes, and precipitation extremes); air-pollution-related health effects; water- and foodborne diseases; and vector- and rodent-borne diseases. We concluded that the levels of uncertainty preclude any definitive statement on the direction of potential future change for each of these health outcomes, although we developed some hypotheses. Although we mainly addressed adverse health outcomes, we identified some positive health outcomes, notably reduced cold-weather mortality, which has not been extensively examined. We found that at present most of the U.S. population is protected against adverse health outcomes associated with weather and/or climate, although certain demographic and geographic populations are at increased risk. We concluded that vigilance in the maintenance and improvement of public health systems and their responsiveness to changing climate conditions and to identified vulnerable subpopulations should help to protect the U.S. population from any adverse health outcomes of projected climate change.
Langfristige Psychotherapie in sozial tragbarer Form
Authors: D. Langen
Journal: Psychotherapy and Psychosomatics (1961)

Research Articles| February 10 2010 Langfristige Psychotherapie in sozial tragbarer Form Subject Area: Psychiatry and Psychology D. Langen D. Langen Tübingen, Aus der Universitäts-Nervenklinik Tübingen Stellvertretender Direktor: Prof. Dr. J. Hirschmann Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1961) 9 (6): 401–409. https://doi.org/10.1159/000285610 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation D. Langen; Langfristige Psychotherapie in sozial tragbarer Form. Acta Psychotherapeutica et Psychosomatica 1 June 1961; 9 (6): 401–409. https://doi.org/10.1159/000285610 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1961Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
Authors: P J Meier, U Eckhardt, A Schroeder, B Hagenbuch, B Stieger
Journal: Hepatology (1997)

The Na + -dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na + -independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.
Diet, microbial virulence, and<i>Helicobacter pylori</i>-induced gastric cancer
Authors: Timothy L Cover, Richard M Peek
Journal: Gut Microbes (2013)

Gastric adenocarcinoma is a leading cause of cancer-related death worldwide, and Helicobacter pylori infection is one of the strongest known risk factors for this malignancy. H. pylori strains exhibit a high level of genetic diversity, and the risk of gastric cancer is higher in persons carrying certain strain types (for example, those that contain a cag pathogenicity island or type s1 vacA alleles) than in persons carrying other strain types. Additional risk factors for gastric cancer include specific human genetic polymorphisms and specific dietary preferences (for example, a high-salt diet or a diet deficient in fruits and vegetables). Finally, iron-deficiency anemia is a risk factor for gastric cancer. Recent studies have provided evidence that several dietary risk factors for gastric cancer directly impact H. pylori virulence. In this review article, we discuss mechanisms by which diet can modulate H. pylori virulence and thereby influence gastric cancer risk.
Use of spiral enteroscopy in a tertiary endoscopy center: initial experience
Authors: M. Riccioni, R. Cianci, C. Spada, G. Costamagna
Journal: Endoscopy (2009)

In their article “The spiral enteroscopy training initiative: results of a prospective study evaluating the Discovery SB overtube device during small bowel enteroscopy,” Buscaglia et al. reported their experience of this new technique during a 2-day training module. The device is described as easy to use and able to be effectively operated after as few as five training cases [1].
Aldosterone Inhibition in Patients With Heart Failure With Preserved Ejection Fraction
Authors: Alberto Milan, Sara Abram, Franco Veglio
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The poor helping the rich: How can incomplete representations monitor complete ones?
Authors: Kristof Strijkers, Elin Runnqvist, Albert Costa, Phillip Holcomb
Journal: Behavioral and Brain Sciences (2013)

Abstract Pickering &amp; Garrod (P&amp;G) propose that inner speech monitoring is subserved by predictions stemming from fast forward modeling. In this commentary, we question this alignment of language prediction with the inner speech monitor. We wonder how the speech monitor can function so efficiently if it is based on incomplete representations.
Direct Effects of Protamine Sulfate on Myocyte Contractile Processes
Authors: R. Barry Hird, Thomas W. Wakefield, Rupak Mukherjee, Blanding U. Jones, Fred A. Crawford, Philip C. Andrews, James C. Stanley, Francis G. Spinale
Journal: Circulation (1995)

Background Administration of the arginine-rich, highly charged protamine (PROT) molecule has been associated with episodes of acute left ventricular (LV) dysfunction. The objective of the present study was to test the hypothesis that PROT has direct effects on isolated LV myocyte contractile processes and sarcolemmal transduction systems. Methods and Results Exposure of porcine LV myocytes (n=305) to 40 μg/mL PROT (reflecting a dose of 2.5 mg/kg) decreased basal contractile function and β-adrenergic responsiveness. For example, myocyte percent shortening was 4.3±0.1% in control myocytes and decreased to 2.8±0.2% in the presence of 40 μg/mL PROT ( P &lt;.05). Myocyte percent shortening was 9.3±0.7% after β-adrenergic receptor stimulation (isoproterenol; 25 nmol/L) and was significantly reduced in the presence of 40 μg/mL PROT (5.7±0.7%, P &lt;.05). PROT reduced myocyte responsiveness to forskolin (100 μmol/L), which directly activates adenylate cyclase, by &gt;40% from forskolin. In addition, PROT abolished the inotropic effects of ouabain on myocyte contractile function. To determine contributory mechanisms for the effects of PROT on myocyte sarcolemmal systems, β-receptor– and cardiac glycoside–binding characteristics were determined in sarcolemmal preparations. β-receptor binding was 175±10 fmol/mg and was reduced to 140±6 fmol/mg in the presence of PROT ( P &lt;.05). Ouabain receptor binding was 7.1 pmol/mg and decreased to 2.6±0.4 pmol/mg in the presence of PROT. In addition, cAMP production after stimulation with isoproterenol and forskolin was significantly blunted in the presence of PROT. Variants of the PROT molecule were constructed by specific amino acid substitutions and deletions, which provided a means to vary charge as well as structure. Substitution of arginine with lysine in the PROT peptide sequence ameliorated the negative effects on myocyte contractile processes; despite identical overall charge (21+). However, a PROT variant with an 18+ charge but different amino acid sequence induced significant negative effects on myocyte function and inotropic responsiveness. Thus, the effects of PROT on myocyte contractile processes are not due simply to the high positive charge of the molecule. To further establish that PROT can contribute to changes in LV function in the clinical setting, fluorescein-labeled PROT was circulated in antegradely perfused rabbit hearts. Microscopic examination revealed that PROT could traverse the vascular compartment of the myocardium and come in direct contact with the myocyte. Conclusions The unique findings from the present study suggest that a fundamental contributory mechanism for the changes in LV function observed after protamine administration may be the direct effect of unbound protamine on myocyte contractile processes.
National reporting system for medical errors is launched
Authors: Vittal Katikireddi
Journal: BMJ (2004)

The world's first national system for collecting reports of health system failures and any error that compromises patients' safety was launched this week.

The national reporting and learning system (NRLS), which aims to improve patients' safety by collecting reports from health professionals across England and Wales, has been developed by the National Patient Safety Agency (NPSA), an organisation established in 2001 to tackle the problem of errors in the NHS.

The system will mostly extract information from existing local risk management systems. However, NHS health professionals will be able to report directly to the system through an online form if no local risk management system …
Children's health and the environment: a new agenda for prevention research.
Authors: P J Landrigan, J E Carlson, C F Bearer, J S Cranmer, R D Bullard, R A Etzel, J Groopman, J A McLachlan, F P Perera, J R Reigart, L Robison, L Schell, W A Suk
Journal: Environmental Health Perspectives (1998)

Patterns of illness in American children have changed dramatically in this century. The ancient infectious diseases have largely been controlled. The major diseases confronting children now are chronic and disabling conditions termed the "new pediatric morbidity"--asthma mortality has doubled; leukemia and brain cancer have increased in incidence; neurodevelopmental dysfunction is widespread; hypospadias incidence has doubled. Chemical toxicants in the environment as well as poverty, racism, and inequitable access to medical care are factors known and suspected to contribute to causation of these pediatric diseases. Children are at risk of exposure to over 15,000 high-production-volume synthetic chemicals, nearly all of them developed in the past 50 years. These chemicals are used widely in consumer products and are dispersed in the environment. More than half are untested for toxicity. Children appear uniquely vulnerable to chemical toxicants because of their disproportionately heavy exposures and their inherent biological susceptibility. To prevent disease of environmental origin in America's children, the Children's Environmental Health Network (CEHN) calls for a comprehensive, national, child-centered agenda. This agenda must recognize children's vulnerabilities to environmental toxicants. It must encompass a) a new prevention-oriented research focus; b) a new child-centered paradigm for health risk assessment and policy formulation; and c) a campaign to educate the public, health professionals, and policy makers that environmental disease is caused by preventable exposures and is therefore avoidable. To anchor the agenda, CEHN calls for long-term, stable investment and for creation of a national network of pediatric environmental health research and prevention centers.
Cubital tunnel syndrome.
Authors: S Renfrew
Journal: BMJ (1979)

In February 1978 the patient went skiing with his school colleagues, and being afraid of taking drugs in the presence of his friends he stopped taking his immunosuppressive therapy for two weeks.Seen again at the end of March 1978 he was azotaemic, with a plasma creatinine of 884 ,umol/l (10-0 mg/100 ml).An open biopsy of the transplant showed the signs of an acute interstitial graft rejection.Under high-dose steroids administered in addition to his continuous immunosuppressive regimen the graft function improved again, and since June 1978 the plasma creatinine is stable at about 256 tmol/l (2 9 mg/100 ml).
Leukocyte Esterase Tests Detect Pyuria, Not Bacteriuria
Authors: Mark S. Lachs
Journal: Annals of Internal Medicine (1993)

Letters1 February 1993Leukocyte Esterase Tests Detect Pyuria, Not BacteriuriaMark S. Lachs, MD, Alvan R. Feinstein, MD, and J. Sanford Schwartz, MDMark S. Lachs, MDSearch for more papers by this author, Alvan R. Feinstein, MDSearch for more papers by this author, and J. Sanford Schwartz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-3-199302010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree that the leukocyte esterase test (like any other diagnostic test) should be judged on its ability to provide additional information for evaluating the total clinical picture. Our study's entry criterion was performance on a urinalysis specifically to diagnose or exclude UTI, based on the patient's history and physical examination, the context of the test's use in clinical practice.We also agree with White and Kunin's description of the potential clinical value of the leukocyte esterase test. We disagree, however, that it is inappropriate to use a clinically diverse population to assess a test with predictive value ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1993Volume 118, Issue 3Page: 230-231KeywordsEsterasesFallsPatientsUrine Issue Published: 1 February 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Vascular Surgery: Principles and Techniques
Authors: Robert L. Hewitt
Journal: JAMA (1976)

This 1,000-page volume with 44 contributing authors is an authoritative text in vascular surgery, complemented with the illustrative detail of an atlas. Thoroughness and clarity of presentation make it valuable for students, while the precision, illustrative content, and organization make it useful for the experienced surgeon as a comprehensive reference in pathology, anatomy, physiology, and surgical techniques. The first of eight parts is concerned with basic considerations: history of vascular surgery, principles of diagnosis, including arteriography and current noninvasive techniques, and prosthetic materials and fundamental techniques of vascular operations. Hemodynamic considerations, thrombogenesis, and anesthetic management are discussed as well. A second part of the text presents detail in operative exposure of arteries and is an excellent atlas of operative exposure. A third division deals with basic considerations and common clinical patterns of arteriosclerosis and adds perspective to the subsequent parts. The fourth and fifth sections, approximately one half of the
Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease
Authors: Nilesh R. Ghugre, Ignacio Gonzalez‐Gomez, Ellen Butensky, Leila Noetzli, Roland Fischer, Roger Williams, Paul Harmatz, Thomas D. Coates, John C. Wood
Journal: American Journal of Hematology (2009)

Abstract Patients with sickle cell disease (SCD) appear to be at lower risk of endocrinopathies and cardiac dysfunction than those with thalassemia major (TM). Circulating redox active iron is lower in these patients, possibly due to increased systemic inflammation and circulating cytokines. Hepcidin synthesis is upregulated during chronic inflammation, reducing intestinal iron absorption and promoting retention of iron in the reticuloendothelial cells. Hence, we hypothesized that livers of patients with SCD would exhibit greater iron deposition in sinusoidal spaces relative to hepatocytes and less in portal tracts when compared to patients with TM. To test this hypothesis, iron scoring analysis was performed on 70 clinically indicated liver biopsy specimens from children and young adults with the two syndromes. Sinusoidal scores were lower in around 1 of 4 patients with TM but the relative iron loading in hepatocytes, and portal tracts was identical in both diseases. Sinusoidal iron burdens saturated at low hepatic iron concentration (HIC) while hepatocyte and portal iron depots increased proportionally to HIC. Liver fibrosis was increased in patients with TM regardless of their chronic hepatitis status. Overall, liver iron distribution was relatively insensitive to differences in disease type and to the presence or absence of hepatitis. Am. J. Hematol., 2009. © 2009 Wiley‐Liss, Inc.
Efficacy and Safety of Inhaled Insulin (Exubera) Compared With Subcutaneous Insulin Therapy in Patients With Type 2 Diabetes
Authors: Priscilla A. Hollander, Lawrence Blonde, Richard Rowe, Adi E. Mehta, Joseph L. Milburn, Kenneth S. Hershon, Jean-Louis Chiasson, Seymour R. Levin
Journal: Diabetes Care (2004)

OBJECTIVE— Glycemic control using inhaled, dry-powder insulin plus a single injection of long-acting insulin was compared with a conventional regimen in patients with type 2 diabetes, which was previously managed with at least two daily insulin injections. RESEARCH DESIGN AND METHODS— Patients were randomized to 6 months’ treatment with either premeal inhaled insulin plus a bedtime dose of Ultralente (n = 149) or at least two daily injections of subcutaneous insulin (mixed regular/NPH insulin; n = 150). The primary efficacy end point was the change in HbA1c from baseline to the end of study. RESULTS— HbA1c decreased similarly in the inhaled (−0.7%) and subcutaneous (−0.6%) insulin groups (adjusted treatment group difference: −0.07%, 95% CI −0.32 to 0.17). HbA1c &amp;lt;7.0% was achieved in more patients receiving inhaled (46.9%) than subcutaneous (31.7%) insulin (odds ratio 2.27, 95% CI 1.24–4.14). Overall hypoglycemia (events per subject-month) was slightly lower in the inhaled (1.4 events) than in the subcutaneous (1.6 events) insulin group (risk ratio 0.89, 95% CI 0.82–0.97), with no difference in severe events. Other adverse events, with the exception of increased cough in the inhaled insulin group, were similar. No difference in pulmonary function testing was seen. Further studies are underway to assess tolerability in the longer term. Insulin antibody binding increased more in the inhaled insulin group. Treatment satisfaction was greater in the inhaled insulin group. CONCLUSIONS— Inhaled insulin appears to be effective, well tolerated, and well accepted in patients with type 2 diabetes and provides glycemic control comparable to a conventional subcutaneous regimen.
Is the Forrest Classification a Useful Tool for Planning Endoscopic Therapy of Bleeding Peptic Ulcers?
Authors: W. Heldwein, J. Schreiner, J. Pedrazzoli, P. Lehnert
Journal: Endoscopy (1989)

See also: Endoscopic Treatment of Bleeding Peptic Ulcers. Good in Every Situation?Endoscopy 1990; 22(04): 201-201DOI: 10.1055/s-2007-1012845
OBSTRUCTION OF THE SUPERIOR VENA CAVA OF TWENTY-FIVE YEARS' DURATION
Authors: Leonard B. Rose
Journal: JAMA (1952)

The survival period following obstruction of the superior vena cava depends to some extent on the underlying cause of the obstruction—a benign lesion of gradual onset would be expected to result in the longest survival. While obstruction of the superior vena cava due to tumor or aneurysm is not uncommon, accounting for 70% to 85% of the cases, benign lesions causing obstruction of this vessel, such as mediastinitis and thrombophlebitis, are relatively uncommon.<sup>1</sup>The present case is reported because of the following points of interest: (1) gradual onset of signs and symptoms during and after a period of recurrent severe infections of the chest wall, strongly suggesting thrombophlebitis as the cause, (2) involvement of the azygos vein, as proved by angiograms and clinical tests (described elsewhere<sup>2</sup>), (3) prolonged survival period of 25 years, indicating adequate compensatory collateral circulation, and (4) minimal symptoms after 25 years, the diagnosis having