tbuckley/cabot-search huggingface dataset:
Lupus Erythematosus and Panhypogammaglobulinemia
Authors: RICHARD J. EPSTEIN
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 January 1984Lupus Erythematosus and PanhypogammaglobulinemiaRICHARD J. EPSTEIN, ROBERT F. OGLER, PAUL A. GATENBYRICHARD J. EPSTEINSearch for more papers by this author, ROBERT F. OGLERSearch for more papers by this author, PAUL A. GATENBYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-162_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sussman and associates (1) report a correlation between the administration of high-dose steroid therapy and the occurrence of panhypogammaglobulinemia in a case of systemic lupus erythematosus. We report a further case of panhypogammaglobulinemia occurring in the context of systemic lupus erythematosus, in which reductions of serum immunoglobulins coincided with the administration of azathioprine.In 1975 a 16-year-old girl was diagnosed as having systemic lupus erythematosus with renal involvement. The diagnosis was supported by clinical findings, positive antinuclear antibody and DNA antibody titres, hypocomplementemia, and renal biopsy results. Serum immunoglobulins (IgG, IgA, and IgM) were within normal limits...References1. SUSSMANRIVERAKOHLER GVP. Transition from systemic lupus erythematosus to common variable hypogammaglobulinemia. Ann Intern Med. 1983;99:32-5. LinkGoogle Scholar2. ASHMANWHITEWIESENHUTTER RRC. Panhypogammaglobulinaemia in systemic lupus erythematosus: in vitro demonstration of multiple cellular defects. J Allergy Clin Immunol. 1982;70:465-73. CrossrefMedlineGoogle Scholar3. STEVENSONFAUCI HA. Effects of corticosteroids on the function and distribution of human lymphocytes. In: FRANKLIN C, ed. Clinical Immunology Update. Churchill Livingstone; 1981: 336-53. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Royal Prince Alfred Hospital Missenden Road; Camperdown, N.S.W. 2050 Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOVERVIEW OF CELLULAR IMMUNE FUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUSHypogammaglobulinemia in a Renal Transplant Recipient With Antiglomerular Basement Membrane DiseaseSystemic lupus erythematosus and common variable panhypogammaglobulinemia: A patient with absence of circulating B cells 1 January 1984Volume 100, Issue 1Page: 162-163KeywordsAntinuclear antibodiesBiopsyDNALupus erythematosusSteroid therapy Issue Published: 1 January 1984 PDF downloadLoading ...
The viral storm: the dawn of a new pandemic age
Authors: Neil Vora
Journal: The Lancet Infectious Diseases (2012)

HIV, severe acute respiratory syndrome, and pandemic influenza A H1N1 are startling reminders of our vulnerability to emerging infectious diseases; indeed, even Hollywood film-makers seem to share this concern lately. In his book, The Viral Storm, Nathan Wolfe explores the origins of pandemics and the bold notion that we might soon enter an era in which pandemics could be stopped before they even begin.
Drug Antisubstitution Laws: Further Comment
Authors: Hugh H. Hussey
Journal: JAMA (1975)

During 1974, the Drug Research Board (DRB) of the National Research Council/National Academy of Sciences (NRC/NAS) held a special meeting with representatives of the Pharmaceutical Manufacturers Association. One outcome of the meeting was a statement supporting the state drug antisubstitution laws and opposing their repeal. When that statement was reviewed at the next regular meeting of the DRB, a representative of the American Pharmaceutical Association (APhA) made a plea for deferral of action at least until representatives of APhA should have had an opportunity to be heard. Accordingly, Dr. Shideman, chairman of the DRB, appointed Dr. James Pittman (chairman) and me as a committee of two to meet with APhA representatives. At the meeting that ensued, the APhA representatives announced that their association had no desire to have the antisubstitution laws repealed—only modified. The arguments were persuasive, and Dr. Pittman presented a report at the next regular meeting of the
I Had a Tough Day Today, Hillary
Authors: S D Boren
Journal: New England Journal of Medicine (1994)

My main office is different from that of most physicians: I am assistant medical director for a very large insurance company. We administer self-insured accounts, as well as conventional, minimal-premium, and experience-rated health care policies. With conventional insurance, the carrier establishes appropriate rates and collects the premiums at the beginning of the month. If the year's claims are lower than expected, the insurance company makes a profit; if there are losses, the insurance company absorbs them. With minimal-premium insurance, the client deposits a set amount of funds with the insurance company each month, and the insurer pays claims from these . . .
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia
Authors: Christine F. Skibola, Martyn T. Smith, Alan Hubbard, Barry Shane, Abby C. Roberts, Graham R. Law, Sara Rollinson, Eve Roman, Raymond A. Cartwright, Gareth J. Morgan
Journal: Blood (2002)
Hospital Peer Review and Clinical Privileges Actions
Authors: Troyen A. Brennan
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Familial Breast and Ovarian Cancer: Genetics, Screening and Management Edited by Patrick J. Morrison, Shirley V. Hodgson, and Neva E. Haites. 401 pp., illustrated. Cambridge, United Kingdom, Cambridge University Press, 2002. $95. 0-521-80373-X
Authors: Anne-Renee Hartman
Journal: New England Journal of Medicine (2003)
Doctors refuse to operate on 80 year old man
Authors: G. Kenyon
Journal: BMJ (1998)

A study was carried out in an inner-city emergency department (ED) of patients returning for related complaints within 48 h of discharge. The incidence was around 0.7% and the majority (82%) of patients presented with persistence or progression of the original symptoms. Patient-related factors accounted for 13% of returns and only 5% were found to be the result of doctor-related factors. Of the returnees, 54% were discharged and 36% were admitted. The most common initial complaint was pain (31%) which, in 23% of patients, was localized to the abdomen. Injury (14%) and febrile illnesses (13%) came second and third. Asthma and chronic obstructive airway diseases (COAD) also accounted for 8% of cases. Children of less than 10 years of age were more likely to return within 48 h. About 18% of cases were thought to be potentially avoidable. Better patient education and an improvement in primary health care services were thought to be important in decreasing such avoidable reattendance. Reattendance audit was a useful tool in the continuous quality improvement programme of emergency department.
Preoperative risk evaluation for lung cancer resection: predicted postoperative product as a predictor of surgical mortality.
Authors: R J Pierce, J M Copland, K Sharpe, C E Barter
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

We assessed the capacity to predict surgical mortality, complications, and functional loss by using the results of resting and exercise respiratory function. Measurements were made before and 4 mo after lung resection in 54 consecutive patients with bronchogenic carcinoma. Predicted postoperative (ppo) FEV1 and DLCO were derived using quantitative lung perfusion scans when baseline FEV1 was < 55% predicted, and by proportional loss of pulmonary segments (total = 19 segments) when FEV1 was > 55% predicted. The patients were aged 67 +/- 7 (mean +/- SD) yr, with an FEV1 of 76 +/- 23% predicted, FEV1/FVC of 55 +/- 13%. and DLCO of 85 +/- 22% predicted. Eleven of the patients had pneumonectomy, 29 had lobectomy, 12 had wedge resection, and two had no resection. Wilcoxon and stepwise logistic regression analyses were used to determine which indices best predicted outcome. Postoperative values were correlated (r = 0.87, p < 0.0001) with actual 4/12 postoperative values of FEV1% and of DLCO (r = 0.56, p < 0.0001). The best predictors (all p < 0.05) for each outcome, in order of usefulness, were as follows. For surgical mortality: (1) the predicted postoperative product (PPP) of ppo FEV1% x ppo DLCO%; (2) ppo DLCO%; (3) ppo FEV1%, and (4) RV, FRC, and SaO2 on the maximal step exercise test. For respiratory complications: body mass index (BMI) (for patients undergoing lobectomy or wedge resection only). For cardiac complications: (1) age; (2) SaO2 at baseline and on the maximal step exercise test; (3) PaO2; (4) PaCO2; and (5) minute ventilation at maximal exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
One in 12 children in Britain are at increased risk of respiratory diseases due to bad housing
Authors: Susan Mayor
Journal: BMJ (2004)

One in 12 children in Britain are at increased risk of respiratory diseases as a result of bad housing, a report on the impact of housing on child health has said.

The report, Toying With Their Future , which was published this week, says that more than one million children in Britain are growing up in overcrowded, unfit, or emergency housing—conditions associated with serious health problems and poor education. The report, based on research done by the housing charity Shelter, showed that one in 12 children in England, Wales, and Scotland were at increased risk of developing diseases such as bronchitis, tuberculosis, or asthma because of their poor housing.

The report brought together findings from previous research studies and research specially commissioned by Shelter to …
Trial of a New Remedy (Ciba 10870) in Parkinsonism
Authors: W. Hughes, J. H. Keevil, I. E. Gibbs
Journal: BMJ (1958)

MEDICAL JOURNAL is of no value-was found here in the two groups investi- gated--those with cutbreaks of violent tempers and those with Parkinsonism.Once again this minor investigation shows that inert substances produce the same effects as drugs with pharmacological properties; they are useful to patients who believe they will get benefit from them, and they cause undesired side-effects; and the side-effects may be present only with the inert tablets and not with the actual drug. SummaryBenactyzine was tested in patients with outbreaks of violent temper and in patients with Parkinsonism.It was of no greater value than control tablets.I thank Drs. Eliot Slater, John Marshall, and John Walton for referring cases to me for this investigation,
Discriminative Use of Blood and Its Fractions
Authors: Buford Ellington
Journal: JAMA (1966)

To the Editor:—  The Subcommittee on Blood, of the Health Resources Advisory Committee, which was appointed by the President to advise me on health preparedness measures, has made the following recommendation:  That the medical services of the Federal Government, and the various civilian medical Associations and Societies, be requested to initiate a program of education of the physician in the discriminating use of whole blood and its fraction, and especially in the use of packed red cells in lieu of whole blood.  This recommendation was made to increase the supplies of plasma required for both civilian and military purposes for the production of plasma protein fractions which are in short commercial supply.
A CONTRIBUTION TO THE STUDY OF PANCREAS INTOXICATION
Authors: E. W. Goodpasture
Journal: The Journal of Experimental Medicine (1917)

1. A toxic constituent is present in the fresh pancreas of dogs before trypsinogen can have been activated. 2. The toxic fraction is present in the beta-nucleoprotein, and therefore is thermostable. 3. It is gradually destroyed by autolysis but can be obtained in concentrated form from a gland which has autolyzed 24 hours. 4. The toxic material is probably protein in nature. 5. Intravenous or intraperitoneal injection of from 0.05 to O.I gm. per kilo of body weight is usually fatal and elicits in dogs symptoms comparable to those of spontaneous hemorrhagic necrosis of the pancreas. 6. Dog pancreas differs from that of beef or pig in that guanylic acid and toxic protein combined with it are slowly broken down by autolysis. 7. After autolysis of dog pancreas the toxic protein and guanylic acid may be separated and obtained in relatively pure form.
Appropriateness of Age Thresholds for Respiratory Syncytial Virus Immunoprophylaxis in Moderate-Preterm Infants
Authors: Almut G. Winterstein, Caitlin A. Knox, Paul Kubilis, Christian Hampp
Journal: JAMA Pediatrics (2013)

<h3>Importance</h3> Recommendations concerning the appropriate age threshold for respiratory syncytial virus (RSV) prophylaxis in moderate-preterm infants are highly debated. <h3>Objective</h3> To determine the age at which moderate-preterm infants' risk of RSV hospitalization has decreased to the risk observed in low-risk term infants. <h3>Design, Setting, and Participants</h3> Retrospective cohort study of Florida and Texas Medicaid fee-for-service billing records matched to birth certificates from Medicaid beneficiaries aged 0 to 12 months with a sibling younger than 5 years and without other indications for RSV prophylaxis between January 1, 1999, and December 31, 2004. <h3>Exposures</h3> For each state, we used discrete time survival analysis to develop age trend models for RSV hospitalizations for 2 groups: moderate-preterm infants (32-34 weeks' gestational age) and term infants (37-41 weeks' gestational age). <h3>Main Outcomes and Measures</h3> Age at which preterm infants' risk of RSV hospitalization equaled the risk for term infants at age 1 month. <h3>Results</h3> Our cohort included 247 566 eligible infants with 5322 RSV hospitalizations. Preterm status doubled the risk for RSV hospitalization in both Florida (odds ratio = 2.41; 95% CI, 1.85-3.12) and Texas (odds ratio = 1.94; 95% CI, 1.64-2.30). Preterm infants' risk of RSV hospitalization was similar to that for 1-month-old term infants at ages 4.2 months (95% CI, 2.5-5.7) in Florida and 4.5 months (95% CI, 2.8-6.4) in Texas. <h3>Conclusions and Relevance</h3> The age at which moderate-preterm infants showed RSV hospitalization risk similar to their healthy term counterparts supports the more restrictive age thresholds in RSV immunoprophylaxis recommendations. Further studies are warranted to investigate the age-dependent risk of RSV hospitalization in other RSV risk groups.
Patient preference trials
Authors: P. Sedgwick
Journal: BMJ (2011)

Researchers compared the efficacy of antidepressant drugs with generic counselling for the treatment of mild to moderate depression in general practice. A randomised controlled trial, with patient preference arms, was conducted. In total, 52 patients were randomised to counselling and 51 to antidepressant drugs, with 140 recruited to the counselling and 80 to the antidepressant preference arms.1 The outcome measures included the Beck depression inventory score at one year follow-up. No differences were reported in Beck scores between the randomised arms or patient preference groups. Patients who chose counselling did better than those who were randomised to it. Which of the following statements, if any, are true?
THERAPEUTIC VALUE OF HYPNOTISM.
Authors: JNO. R. ROSE
Journal: JAMA (1899)

A general anesthesia can be brought about by proper suggestions, and this can be utilized with the happiest results in obstetric practice; I have come across the record of several cases where childbirth took place during hypnosis without the mother being aware of it and in one case refusing to believe it on awakening; in all, this has evidently been due to faulty suggestions given by persons not fully understanding the inhibitory power of hypnosis, and the best plan to pursue is in suitable cases to gauge the inhibition only sufficiently deep to produce freedom from pain or suffering, and not deep enough to cause loss of consciousness nor amnesia on waking.  This inclination or desire on the part of a hypnotized person to translate suggestions into acts through both voluntary and automatic channels is taken advantage of as a therapeutic measure for the relief of pathologic conditions. Dr. Brouardel,
Computer screening for early detection of melanoma—is there a future?
Authors: P. N. HALL, E. CLARIDGE, J. D. MORRIS SMITH
Journal: British Journal of Dermatology (1995)

Computer image analysis in the study of pigmented lesions is critically examined and discussed in the light of the current published data. The potential for objective analysis by computers as a possible screening aid for the inexperienced clinician is discussed. The future for this technology is exciting if handled with care.
Concomitant erythrasma and dermatophytosis of the groin
Authors: OTTO L.A. SCHLAPPNER, GERALD A. ROSENBLUM, GEOFFREY ROWDEN, TERRENCE M. PHILLIPS
Journal: British Journal of Dermatology (1979)

Four patients are reported with concomitant erythrasma and trichophyton rubrum dermatophytosis of the groin. The recognition and diagnosis of these associated infections is emphasized.
Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression
Authors: Alexandre Bougdour, Eric Durandau, Marie-Pierre Brenier-Pinchart, Philippe Ortet, Mohamed Barakat, Sylvie Kieffer, Aurélie Curt-Varesano, Rose-Laurence Curt-Bertini, Olivier Bastien, Yohann Coute, Hervé Pelloux, Mohamed-Ali Hakimi
Journal: Cell Host & Microbe (2013)
Book Review Cardiology: An illustrated text/reference Edited by Kanu Chatterjee, Melvin D. Cheitlin, Joel Karliner, William W. Parmley, Elliot Rapaport, and Melvin Scheinman. Approximately 1800 pp. in two volumes, illustrated. Philadelphia, J.B. Lippincott/Gower Medical, 1991. $225.
Authors: Andrew R. Weintraub
Journal: New England Journal of Medicine (1992)
Quality of Life Improves for Pediatric Patients After Total Pancreatectomy and Islet Autotransplant for Chronic Pancreatitis
Authors: Melena D. Bellin, Martin L. Freeman, Sarah Jane Schwarzenberg, Ty B. Dunn, Gregory J. Beilman, Selwyn M. Vickers, Srinath Chinnakotla, A.N. Balamurugan, Bernhard J. Hering, David M. Radosevich, Antoinette Moran, David E.R. Sutherland
Journal: Clinical Gastroenterology and Hepatology (2011)
Blackwater Fever and Malaria
Authors: G. Thin
Journal: BMJ (1900)

The present study aimed to investigate how the heat-related increase in deaths in summer and the extent of mortality displacement depend on influenza and other categories of mortality in the previous winter, which when low leaves a greater pool of susceptible individuals. Mortality data from Stockholm, Sweden, from 1990–2002 were stratified into a summer period and a winter period. A Poisson regression model was established for the daily mortality in the summer, with temperature and confounders as explanatory variables. In addition, indicators of total, respiratory, cardiovascular and influenza mortality of the winter period were incorporated as effect modifiers in the summer model, and lagged effects in strata defined by indicators were studied. A high rate of respiratory as well as cardiovascular mortality in winter reduced the heat effect the following summer, and influenza mortality tended to do so as well. The cumulative effect per °C increase was 0.95% below and 0.89% above a threshold (21.3°C) after a winter with low cardiovascular and respiratory mortality, but -0.23% below and 0.21% above the threshold after a winter with high cardiovascular and respiratory mortality. The current study shows that high respiratory, cardiovascular and influenza mortality in winter leads to lower temperature effects in the following summer. It also suggests that persons for whom influenza may be fatal are often also susceptible to heat and this subgroup might, therefore, not benefit as much as expected from influenza vaccinations.
Early Signs of Landouzy-Déjerine Disease: Wrist and Finger Weakness
Authors: Irwin M. Siegel
Journal: JAMA (1972)

To the Editor.—  Facioscapulohumeral muscular dystrophy (Landouzy-Dejerine disease) is characterized by total penetrance in either sex, autosomal dominant transmission usually, variable expression where forme fruste cases are common, insidious progress with initial facial and shoulder weakness and subsequent involvement of the pelvic girdle, uncommon pseudohypertrophy, and rare contracture and deformity.  Walton 1 noted that one of the striking features of this disease is the occurrence of partially affected or abortive cases. In such instances, weakness may remain confined to one or two muscles or muscle groups indefinitely, and many of these patients are unaware they suffer from the disease in its mild form. Walton emphasized the importance of examining all available family members in studying the inheritance of this disorder. This report documents one such case, in which the only complaint was wrist and finger weakness.  Report of a Case.—  A 15-year-old white boy complained of slowly progressive extension weakness
The Hospital Trustees' Dilemma
Authors: John L. Sinn
Journal: New England Journal of Medicine (1985)

BY a curious coincidence, during the current period of corporate takeovers (some voluntary and others involuntary) that highlights the business world in general, a similar onslaught of takeovers is besetting the hospital field. The large hospital corporate chains are seeking to purchase many not-for-profit hospitals, including some university teaching facilities.The decision whether or not to sell rests entirely with the hospital's board of trustees. It is but the latest in a long series of increasing obligations that have fallen on the trustee. A number of court decisions have by now made it clear that the trustee is indeed the . . .
Sciences of New Importance to Medicine
Authors: J. Walter Wilson
Journal: JAMA (1963)

I ACCEPTED MY TITLE NAIVELY. It was not until I sat down to prepare my talk that I realized it presents some problems. Am I to talk about Medicine (with a capital M) or the practice of medicine? It has been reported to me that in a neighboring medical school the students, confronted with new editions of histology textbooks, have raised the question, "How will a knowledge of the cristae of mitochondria and the difference between smooth and rough endoplasmic reticulum make me a better doctor?" To reply by asking the question, "Is medicine a science or an art?" would be trite—and would also present an antithesis which I have long felt to be invalid. From time immemorial science has been considered one of the arts. In addition to logic and experiment it involves the same creative imagination as the rest of the arts and affords the same kind
Melphalan and dexamethasone with or without bortezomib in newly diagnosed AL amyloidosis: a matched case–control study on 174 patients
Authors: G Palladini, P Milani, A Foli, M Vidus Rosin, M Basset, F Lavatelli, M Nuvolone, L Obici, S Perlini, G Merlini
Journal: Leukemia (2014)