Hepatitis B in Patients with HIV Infection: Relationship to AIDS and Patient Survival
Authors: Bruce F. Scharschmidt, Michael J. Held, Harry H. Hollander, Alexandra E. Read, Joel E. Lavine, Genevieve Veereman, Richard F. McGuire, M. Michael Thaler
Journal: Annals of Internal Medicine (1992)

Brief Report15 November 1992Hepatitis B in Patients with HIV Infection: Relationship to AIDS and Patient SurvivalBruce F. Scharschmidt, MD, Michael J. Held, MA, Harry H. Hollander, MD, Alexandra E. Read, MD, Joel E. Lavine, MD, PhD, Genevieve Veereman, MD, Richard F. McGuire, MD, M. Michael Thaler, MDBruce F. Scharschmidt, MD, Michael J. Held, MA, Harry H. Hollander, MD, Alexandra E. Read, MD, Joel E. Lavine, MD, PhD, Genevieve Veereman, MD, Richard F. McGuire, MD, M. Michael Thaler, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-10-837 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHepatitis B virus (HBV) infection is common among persons with human immunodeficiency virus (HIV) infection (1-4). Hepatitis B virus DNA is found in lymphoid cells of patients co-infected with HBV and HIV (5), and studies in cultured cells co-infected or transfected with HIV and HBV DNA indicate that the HBV X gene product enhances HIV gene expression (6, 7). These findings suggest that infection with HBV may accelerate progression of HIV-related disease, but limited clinical information is available. Therefore, we retrospectively analyzed sera from 511 HIV-infected patients for evidence of hepatitis B, in order to examine the relationship between serologic...References1. SchreederThompsonHadlerBerquistZaidiMaynard MSSKAJ. Hepatitis B in homosexual men: prevalence of infection and factors related to transmission. J Infect Dis. 1982;146:7-15. CrossrefMedlineGoogle Scholar2. PerrilloRegensteinRoodman RFS. Chronic hepatitis B in asymptomatic homosexual men with antibody to the human immunodeficiency virus. Ann Intern Med. 1986;105:382-3. LinkGoogle Scholar3. HomannKrogsgaardPedersenAnderssonNielsen CKCPJ. High incidence of hepatitis B infection in patients with advanced HIV infection. J Acquir Immune Defic Syndr. 1991;4:416-20. MedlineGoogle Scholar4. OuattaraMeiteAronAkranGodyManlan SMYVML. Increase of the prevalence of hepatitis B virus surface antigen related to immunodeficiency inherent in acquired immune deficiency syndrome (AIDS). J Acquir Immune Defic Syndr. 1990;3:282-386. MedlineGoogle Scholar5. HirschmanZucker SM. Recombinant DNA related to hepatitis B and human immunodeficiency viruses in mononuclear cells of patients with AIDS. J Med Virol. 1988;26:145-52. CrossrefMedlineGoogle Scholar6. TwuChuRobinson JKW. Hepatitis B virus X gene activate kB-like enhancer sequences in the long terminal repeat of human immunodeficiency virus 1. Proc Natl Acad Sci. 1989;86:5168-72. CrossrefMedlineGoogle Scholar7. SetoYenPeterlinOu ETBJ. Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc Natl Acad Sci. 1988;85:8286-90. CrossrefMedlineGoogle Scholar8. Cox D. Regression models and life tables. Journal of the Royal Statistical Society (Series B). 1972;34:187-202. Google Scholar9. HoughtonLeevyOleske JCJ. AIDS in children is associated with a high incidence of HBV infections [Abstract]. Clin Res. 1989;37:368A. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University of California, San Francisco, California. For current author addresses, see end of text. 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