tbuckley/cabot-search huggingface dataset:
Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
Authors: Max S. Topp, Nicola Gökbuget, Gerhard Zugmaier, Evelyn Degenhard, Marie-Elisabeth Goebeler, Matthias Klinger, Svenja A. Neumann, Heinz A. Horst, Thorsten Raff, Andreas Viardot, Matthias Stelljes, Markus Schaich, Rudolf Köhne-Volland, Monika Brüggemann, Oliver G. Ottmann, Thomas Burmeister, Patrick A. Baeuerle, Dirk Nagorsen, Margit Schmidt, Hermann Einsele, Gert Riethmüller, Michael Kneba, Dieter Hoelzer, Peter Kufer, Ralf C. Bargou
Journal: Blood (2012)
Rural Health Care-Reply
Authors: William J. Kane
Journal: JAMA (1979)

Mr Frary's comments are appreciated, and I believe that we have no strong disagreement. I believe that isolated rural areas will receive their health care from physician extenders with support and backup from physicians. My experience with residency graduates leads me to believe that there will be few physicians willing to enter a rural area without another physician and that the team composed of a family physician and a physician's assistant will not be overly popular. Since the laws in most states will require the physician to be immediately available to the physician's assistant, the physician will still be subject to extremely long hours and little time off. The satellite clinic model is still the most suitable answer, with most physicians located in areas with a population density of 5,000 to 6,000 people.  Despite problems with the recent Rural Health Clinics legislation, I still think that legislation will
Adsorption of organic chemicals in soils.
Authors: R Calvet
Journal: Environmental Health Perspectives (1989)

This paper presents a review on adsorption of organic chemicals on soils sediments and their constituents. The first part of this review deals with adsorption from gas and liquid phases and gives a discussion on the physical meaning of the shape of adsorption isotherms. Results show that no general rules can be proposed to describe univocally the relation between the shape of isotherms and the nature of adsorbate-adsorbent system. Kinetics of adsorption is discussed through the description of various models. Theoretical developments exist both for the thermodynamics and the kinetics of adsorption, but there is a strong need for experimental results. Possible adsorption mechanisms are ion exchange, interaction with metallic cations, hydrogen bonds, charge transfers, and London-van der Waals dispersion forces/hydrophobic effect. However, direct proofs of a given mechanism are rare. Several factors influence adsorption behavior. Electronic structure of adsorbed molecules, properties of adsorbents, and characteristics of the liquid phase are discussed in relation to adsorption. Such properties as water solubility, organic carbon content of adsorbing materials, and the composition of the liquid phase are particularly important. Evaluation of adsorption can be obtained through either laboratory measurements or use of several correlations. Adsorption measurements must be interpreted, taking into account treatment of adsorbent materials, experimental conditions, and secondary phenomena such as degradations. Correlations between adsorption coefficients and water-octanol partition coefficient or water solubility are numerous. They may be useful tools for prediction purposes. Relations with transport, bioavailability, and degradation are described.
Pulmonary embolism after sclerotherapy treatment for variceal bleeding
Authors: J. Escardo, S. Cosenza, J. Alvarez, P. Pratesi, G. Parra, A. Hita
Journal: Endoscopy (2007)

A 51-year-old man presented to the emergency department with upper gastrointestinal bleeding. He had a history of portal hypertension and cirrhosis. On admission, he was lucid and stable.
Levels of observation
Authors: T. Dalrymple
Journal: BMJ (2011)

All art, said Walter Pater, aspires to the condition of music. Whether this be so or not, the Swiss novelist and dramatist, Friedrich Durrenmatt (1921-1990) certainly wrote the novel The Assignment: or, on the Observing of the Observer of the Observers after listening to a recording of Glenn Gould playing the first half of Bach’s The Well-Tempered Clavier . He decided then to write a novel in 24 sentences, either in imitation or in honour of Bach; not surprisingly the book is short, but the sentences are long.

It is a technical accomplishment to write a sentence several pages long that is both lucid and easy to …
A Figure-Eight Elastic Knee Support
Authors: John Bate
Journal: JAMA (1973)

To the Editor.—  Inasmuch as we have had some patients with residual discomfort following injuries to the knee and operations upon the knee for injuries that were not relieved by conventional elastic bandages, elastic kneecaps, or knee cages, a brace maker was requested to make a 5.8-cm elastic webbing strap approximately 76.2 cm long with a buckle at one end and well padded under the buckle with felt. This was wound around the area above and below the knee as a figure eight so that the knee was open anteriorly but the straps crossed over the popliteal area posteriorly. This figure-eight support gave great benefit in an individual who had suffered a football injury before the era of moderate knee-reparative surgery. Probably there had been injury to the medial meniscus, medial collateral ligament, and, possibly, the anterior cruciate ligament. As a result, late in life he was having symptoms apparently
Current consensus and guidelines of contrast enhanced ultrasound for the characterization of focal liver lesions
Authors: Jae Young Jang, Moon Young Kim, Soung Won Jeong, Tae Yeob Kim, Seung Up Kim, Sae Hwan Lee, Ki Tae Suk, Soo Young Park, Hyun Young Woo, Sang Gyune Kim, Jeong Heo, Soon Koo Baik, Hong Soo Kim, Won Young Tak
Journal: Clinical and Molecular Hepatology (2013)

The application of ultrasound contrast agents (UCAs) is considered essential when evaluating focal liver lesions (FLLs) using ultrasonography (US). Microbubble UCAs are easy to use and robust; their use poses no risk of nephrotoxicity and requires no ionizing radiation. The unique features of contrast enhanced US (CEUS) are not only noninvasiveness but also real-time assessing of liver perfusion throughout the vascular phases. The later feature has led to dramatic improvement in the diagnostic accuracy of US for detection and characterization of FLLs as well as the guidance to therapeutic procedures and evaluation of response to treatment. This article describes the current consensus and guidelines for the use of UCAs for the FLLs that are commonly encountered in US. After a brief description of the bases of different CEUS techniques, contrast-enhancement patterns of different types of benign and malignant FLLs and other clinical applications are described and discussed on the basis of our experience and the literature data.
Spirituality and Chronic Illness
Authors: Thomas J. Flynn, Charles B. Fulton
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Perinatal mortality in the Netherlands
Authors: M. J N C Keirse
Journal: BMJ (2009)

Consistently poor performance indicates that it is time for change

The Netherlands’ consistently poor performance in the European perinatal mortality league is a cause for concern. Neither the concern nor the performance are new. They culminated in the late 1970s and mid-1980s when home births were erroneously put forward as the explanation.1 A new height was reached when the Peristat project showed that at the turn of this century the Netherlands had the highest perinatal mortality in the European Union.1 Five years on, nine new EU members have expanded the league from 15 to 24, but this has brought little change.2 In 2004, perinatal mortality was 10 per 1000 in the Netherlands, higher than in all but one of the new EU members,2 and still 9.8 per 1000 in 2006.3 

Admittedly, the European perinatal mortality league is a poor relation of the European football league, not just because it takes four years before the results are announced.2 Not all teams play by the same rules. Some nations register births for babies ≥500 g; others from 22, 24, or 28 weeks’ gestation; and some have …
US outlines plan to reduce use of antimicrobials in food production
Authors: M. McCarthy
Journal: BMJ (2013)

To combat the growing threat of antimicrobial resistance the US Food and Drug Administration has launched a three year initiative to curtail the use of medically important antimicrobials in food production.

Food producers commonly add antimicrobials to animal feed and water to accelerate animal growth, a practice that has been linked to the spread of resistance to drugs in human pathogens. It is estimated that about 80% of antimicrobials sold in the United States are used in farm animal production.

Under the new plan, makers of animal pharmaceuticals are being asked …
Brain Tumors in Children
Authors: I. J. Ertel
Journal: CA A Cancer Journal for Clinicians (1980)

Brain tumors are relatively common cancers among children, just as they are among adults. Unlike the tumors of adults, however, they have a predilection for the posterior fossa. The most common types of tumors among children are astrocytomas, ependymomas, and medulloblastomas. The definitive diagnosis of these lesions can usually be made with relative ease by CT scans of the brain. Treatment typically consists of the surgical removal of all or as much tumor as possible, followed by radiation therapy, and occasionally also by chemotherapy with one of the nitrosoureas combined with vincristine and/or other antitumor drugs. Recurrence-free survival may be expected for about half of the children past infancy who develop brain tumors. The substantial progress recently made in both the diagnosis and treatment of brain tumors in childhood has heightened, not diminished, the clinical responsibilities of primary care clinicians throughout the management of this disease. Since tumor-free survival so heavily depends upon an early diagnosis, a high index of suspicion must be maintained for commonplace non-specific symptomatology. The primary physician must pursue critical aspects of the medical history at the first suggestion of an atypical course. A skillful physical examination is then needed to detect subtle clinical signs that are indicators for the prompt performance of definitive diagnostic tests. Further, since there are now so many therapeutic modalities that can be brought into the comprehensive management of children with brain tumors, the primary clinician should maintain close contact with the patient not only to provide medical and psychological support, but also to monitor the clinical response or side effects of therapeutic agents and to serve as the patient advocate at times of great personal and family need.
Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon
Authors: R G Hardy
Journal: Gut (2002)

Background: Colorectal adenomatous and, probably, hyperplastic polyp development requires epithelial remodelling and stratification, with loss of E-cadherin expression implicated in adenoma formation. We have shown that P-cadherin, normally expressed in stratified epithelia and placenta, is aberrantly expressed in disturbed epithelial architecture associated with colitis. Aims: (i) To investigate the role of P-cadherin in colonic polyp formation. (ii) To ascertain whether expression of P-cadherin is independent of or correlated with expression of its associated proteins— E-cadherin, β-catenin, and γ-catenin. (iii) To determine if P-cadherin is functional regarding catenin binding in polyps. Methods: Expression and localisation of cadherins (E- and P-) and their associated catenins (β- and γ-) were determined in aberrant crypt foci (ACF), in polyps with hyperplastic morphology (hyperplastic polyps and serrated adenomas), and in adenomatous polyps by immunohistochemistry, western blotting, and mRNA in situ hybridisation. Assessment of cadherin-catenin binding was evaluated by co-immunoprecipitation. Adenomatous polyposis coli (APC) mutation was assessed in adenomatous polyps. Results: P-cadherin was expressed from ACF through to hyperplastic and adenomatous polyps. Alterations in E-cadherin and catenin expression occurred later, with variant patterns in (i) ACF, (ii) hyperplastic polyps and serrated adenomas, and (iii) adenomatous polyps. P-cadherin present in adenomas was functional with regard to catenin binding, and its expression was independent of APC mutational status. Conclusions: P-cadherin is aberrantly expressed from the earliest morphologically identifiable stage of colonocyte transformation, prior to changes in E-cadherin, catenin, and APC expression/mutation. P-cadherin expression alone does not predict tissue morphology, and such expression is independent of that of associated cadherins and catenins.
Streptolinase and serum enzymes.
Authors: J T Shepherd, S S Rao, J R Lawrence, M J Brodie, W F Fulton
Journal: BMJ (1976)

Streptokinase and serum enzymesWe have recently observed a rise in the serum transaminase (aspartate aminotransferase, AST; and alanine aminotransferase, ALT) levels in patients who received a 24-hour course of streptokinase.The patterns of this enzyme rise suggests a hepatic source.
US given more time to consider cheap drugs deal for poor nations
Authors: F. Fleck
Journal: BMJ (2003)

Trade negotiators said on Monday they needed more time to persuade the United States to agree to a revised deal that would give African and other poor nations access to cheap, lifesaving drugs.

Negotiators for the 144 member countries of the World Trade Organization failed to meet their deadline of reaching agreement by the end of 2002 after the United States, under pressure from its powerful pharmaceutical lobby, blocked the deal.

Eduardo Perez Motta, Mexico's envoy at the organisation …
Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33–q35
Authors: Afif Hentati, Khemissa Bejaoui, Margaret A. Pericak-Vance, Faycal Hentati, Marcy C. Speer, Wu-Yen Hung, Denise A. Figlewicz, Jonathan Haines, Jackie Rimmler, Christiane Ben Hamida, Mongi Ben Hamida, Robert H. Brown, Teepu Siddique
Journal: Nature Genetics (1994)
The Editor, 'The British Journal of Dermatology'. Seborrhoeic dermatitis with moniliasis.
Authors: J. Jefferson
Journal: British Journal of Dermatology (1967)

Journal Article The Editor, ‘The British Journal of Dermatology’. Seborrhoeic dermatitis with moniliasis. Get access J. Jefferson J. Jefferson Belfast City Hospital, Belfast, 9 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 12, 1 December 1967, Pages 722–724, https://doi.org/10.1111/j.1365-2133.1967.tb11448.x Published: 01 December 1967
THE MECHANISM OF THE VOMITING INDUCED BY ANTIMONY AND POTASSIUM TARTRATE (TARTAR EMETIC)
Authors: Soma Weiss, Robert A. Hatcher
Journal: The Journal of Experimental Medicine (1923)

1. It has been shown that tartar emetic acts on the stomach to induce emesis after its oral administration, that only traces are present in the vomitus following its intravenous injection (Kleimann and Simonowitsch), and that it does not induce emesis when it is applied directly to the vomiting center (Thumas). 2. In the present study, which was made with cats except when otherwise specifically stated, the intravenous injection of tartar emetic caused emesis (typical vomiting movements) after the removal of the entire gastrointestinal tract from the esophagus to the anus. 3. Cutting the vagi inhibits emesis after the intravenous injection of any dose of tartar emetic, though nausea may be induced. 4. Cutting the vagi and simultaneously extirpating the stellate ganglia inhibits both nausea and vomiting after the intravenous injection of tartar emetic. 5. Extirpation of the celiac ganglion and simultaneous cutting of the vagi just below the level of the diaphragm does not prevent emesis following the intravenous injection of tartar emetic. 6. Cutting the vagi prevents vomiting after the introduction of large doses of tartar emetic into the stomach, but massive doses may still cause emesis. Vagotomy probably has less influence on the emetic action of a moderately large dose of tartar emetic introduced into a loop of the duodenum. 7. Atropine has very nearly the same effect on the emetic action of tartar emetic as cutting the vagi, but much larger doses are necessary to abolish the effect of the introduction of tartar emetic into the stomach in moderate amounts than that of equal amounts injected intravenously. 8. The facts just stated point to the heart as the seat of reflex vomiting following the intravenous injection of tartar emetic. 9. The intravenous injection of tartar emetic induces afferent emetic impulses which pass from the heart to the vomiting center mainly by way of the vagus, to a much less extent by way of the sympathetic nerve and the stellate ganglia. 10. The introduction of tartar emetic into the stomach induces afferent emetic impulses which pass upward mainly by way of the vagus, to a much less extent by way of the sympathetic nerve. 11. The introduction of tartar emetic into the duodenum induces afferent emetic impulses which pass upward partly by way of the sympathetic nerve, partly by way of the vagus. 12. It seems probable that the path taken by afferent emetic impulses induced in the gastrointestinal tract by tartar emetic depends on the innervation of the organ concerned, and not on any selective action of the poison on the afferent nerve.
Trust faces sex discrimination claim
Authors: M. Hunter
Journal: BMJ (2001)

Five women consultant psychiatrists have launched a sex discrimination action against an NHS trust alleging that male consultants received pay deals worth up to £15 000 ($22 500) more than those offered to their female colleagues.

The case will centre around perks and pay enhancements offered by the Foundation NHS Trust, which has since become part of the South Staffordshire NHS Trust.

The women claim that the trust struck “sweetheart deals” with male consultants, offering them extra payments for working from home, making …
A Prospective Study of Alexithymia in Obsessive-Compulsive Patients Treated with Multimodal Cognitive-Behavioral Therapy
Authors: Michael Rufer, Iver Hand, Anne Braatz, Heike Alsleben, Susanne Fricke, Helmut Peter
Journal: Psychotherapy and Psychosomatics (2004)

&lt;i&gt;Background:&lt;/i&gt; Alexithymia as a predictor of treatment outcome in psychotherapy has often been discussed but rarely evaluated in prospective studies. The present study evaluated the absolute and relative stability of alexithymia in patients with obsessive-compulsive disorder (OCD), and the predictive value of alexithymia for the outcome of treatment. &lt;i&gt;Methods:&lt;/i&gt; We conducted a prospective study with 42 inpatients receiving intensive, multimodal cognitive-behavioral therapy (CBT). Patients were assessed for alexithymia at pre- and post-treatment with the 20-item Toronto Alexithymia Scale (TAS-20), for obsessive-compulsive symptoms and depression with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and the 21-item Hamilton Depression Rating Scale (HDRS). &lt;i&gt;Results:&lt;/i&gt; OCD and comorbid depression showed a highly significant symptom-reduction from pre- to post-treatment while no absolute changes in the TAS-20 total scores and its factors 1 and 3 occurred. Only factor 2 scores decreased significantly, but with a smaller effect size than the effect sizes for the changes in Y-BOCS and HDRS. Alexithymia scores at pre-treatment correlated significantly with alexithymia scores at the end of treatment, indicating its relative stability. In the linear regression analyses, no variables were identified that predicted significantly the outcome of treatment. &lt;i&gt;Conclusions:&lt;/i&gt; Our findings support the view that alexithymia is a stable personality trait rather than a state-dependent phenomenon in obsessive-compulsive patients. Alexithymia scores do not predict response to multimodal CBT in OCD. It might be an effect of CBT that patients could at least partly regain or newly learn the capability to describe their feelings.
A Second Radiographic Skeletal Survey for Child Abuse Triggered by Bone Scintigraphy Found Positive After the Initial Survey Was Called Negative
Authors: Gethin Williams, S Ted Treves
Journal: Clinical Nuclear Medicine (2006)

A 6 month old, previously reported as a “robust,” healthy boy, presented with the mother reporting that when she tried to change his diaper, she “heard a crack.” Also noted were periorbital small skin abrasions bilaterally. An ophthalmologic examination was negative; a skeletal survey noted a left femoral fracture. Routine bone scintigraphy was undertaken for suspected child abuse. This scan was positive and the child was recalled for another skeletal survey. This second skeletal survey noted a contralateral femoral subperiosteal reaction which, together with a healing femoral classic metaphyseal lesion, strongly suggested nonaccidental injury.
Use of Animals in Medical Education
Authors: Kent Hoffman
Journal: JAMA (1991)

<h3>To the Editor.</h3> —I take great exception to the Council's report<sup>1</sup>regarding the use of animals in medical education. Animal dissection and/or "study" has no place in modern medical education. We treat people, not animals. Animal anatomy is very different from human anatomy, and the study of it is of minimal use to a practicing physician. It would seem more appropriate to learn anatomy from human cadavers, models, and learning aides. Physiology is best learned in the classroom. As a medical student, I was forced to take part in a dog laboratory, where we systematically injected potassium chloride into intubated dogs to watch their hearts stop. No medical knowledge was learned from this execution. The only thing this type of thing teaches is that life is cheap. It is easy to progress from animal abuse to human abuse. Even now, our profession is under fire for indifference to patient