tbuckley/cabot-search huggingface dataset:
Acute Myeloid Leukemia and Erythroleukemia
Authors: E. Del Potro, I. Krsnik, J. Diaz Media Villa, A. Villegas, D. Espinos, M.T. Ferro
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 February 1986Acute Myeloid Leukemia and ErythroleukemiaE. DEL POTRO, M.D., I. KRSNIK, M.D., J. DIAZ MEDIA VILLA, M.D., A. VILLEGAS, M.D., D. ESPINOS, M.D., M.T. FERRO, M.D.E. DEL POTRO, M.D.Search for more papers by this author, I. KRSNIK, M.D.Search for more papers by this author, J. DIAZ MEDIA VILLA, M.D.Search for more papers by this author, A. VILLEGAS, M.D.Search for more papers by this author, D. ESPINOS, M.D.Search for more papers by this author, M.T. FERRO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-281 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The French-American-British (FAB) Group (1) has proposed several revisions in an attempt to improve their classification of acute myeloid leukemia. For Bloomfield and Brunning (2), the new criteria resolve some difficulties, but they believe that immunologic and cytogenetic findings must be added to resolve the remaining problems. We write to present a case that shows the importance of the new diagnostic criteria for the differential diagnosis between erythroleukemia and myelodysplastic syndrome in a patient with interesting chromosomal findings.A 78-year-old man with a 3-week history of asthenia presented with pallor; a systolic murmur, and 3-cm hepatomegaly. Laboratory...References1. BENNETTCATOVSKYDANIEL JDM. Proposed revised criteria for the classification of acute myeloid leukemia: a report of the French-American-British Cooperative Group. Ann Intern Med. 1985;103:620-5. LinkGoogle Scholar2. BLOOMFIELDBRUNNING CR. The revised French-American-British classification of acute myeloid leukemia: is new better [Editorial]? Ann Intern Med. 1985;103:614-6. LinkGoogle Scholar3. BENNETTCATOVSKYDANIEL JDM. Proposals for the classification of the acute leukemias: French-American-British (FAB) Cooperative Group. Br J Haematol. 1976;33:451-8. CrossrefMedlineGoogle Scholar4. SAKURAISANDBERG MA. Chromosomes and causation of human cancer and leukemia: an evaluation of karyotypic findings in erythroleukemia. Cancer. 1976;37:790-804. CrossrefMedlineGoogle Scholar5. KOCOVASANDBERG MA. Major karyotypic abnormalities in a neartetraploid erythroleukemia. Cancer Genet Cytogenet. 1985;17:143-50. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Centro Especial Ramon y Cajal Madrid España PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1986Volume 104, Issue 2Page: 281-281KeywordsAcute myeloid leukemiaChromosomesCytogeneticsHepatomegalyMyelodysplastic syndromesResearch laboratoriesSystolic ejection murmur Issue Published: 1 February 1986 PDF DownloadLoading ...
Predicting Clinical Outcomes After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma
Authors: Eugene K. Cha, Shahrokh F. Shariat, Matthias Kormaksson, Giacomo Novara, Thomas F. Chromecki, Douglas S. Scherr, Yair Lotan, Jay D. Raman, Wassim Kassouf, Richard Zigeuner, Mesut Remzi, Karim Bensalah, Alon Weizer, Eiji Kikuchi, Christian Bolenz, Marco Roscigno, Theresa M. Koppie, Casey K. Ng, Hans-Martin Fritsche, Kazumasa Matsumoto, Thomas J. Walton, Behfar Ehdaie, Stefan Tritschler, Harun Fajkovic, Juan I. Martínez-Salamanca, Armin Pycha, Cord Langner, Vincenzo Ficarra, Jean-Jacques Patard, Francesco Montorsi, Christopher G. Wood, Pierre I. Karakiewicz, Vitaly Margulis
Journal: European Urology (2012)
Simultaneous Detection of Breast Tumor Resection Margins and Radioguided Sentinel Node Biopsy Using an Intraoperative Electronically Collimated Probe With Variable Energy Window
Authors: Gianpiero Manca, Elisa Biggi, Alice Lorenzoni, Giuseppe Boni, Manuela Roncella, Matteo Ghilli, Duccio Volterrani, Giuliano Mariani
Journal: Clinical Nuclear Medicine (2011)

Breast-conserving surgery with intraoperative assessment of lesion margins and sentinel lymph node biopsy has become the preferred method of treatment for selected patients with early infiltrating breast cancer. A high-energy gamma probe, designed according to a novel concept of electronic collimation and variable energy window, was used in a patient with nonpalpable infiltrating breast cancer to perform simultaneous intraoperative identification of lesion margins (based on the detection of the high-energy gamma rays originated from annihilation following preoperative administration of F-18 FDG) and radioguided sentinel node biopsy (based on the single-photon agent Tc-99m-nanocolloid used for lymphoscintigraphy).
Increased IP-10 and MIG Expression after Intra-amniotic Endotoxin in Preterm Lamb Lung
Authors: Suhas G. Kallapur, Alan H. Jobe, Machiko Ikegami, Cindy J. Bachurski
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

Subtraction hybridization was performed to explore changes in gene expression in the fetal lung after 20 mg of intra-amniotic (IA) endotoxin. Interferon-gamma-inducible 10-kd protein (IP-10) and monokine induced by interferon-gamma (MIG) constituted 20% of 102 endotoxin-induced clones identified in the preterm lamb lung. IP-10 (CXCL10) and MIG (CXCL9) are T-cell chemoattractants that have angiostatic properties. Both IP-10 and MIG mRNA were induced 30- to 40-fold in the fetal lung at 1 to 2 days after IA endotoxin. Intense IP-10 mRNA expression was detected by in situ hybridization in the bronchiolar and peribronchiolar areas and the vascular endothelium after IA endotoxin at all time points tested. MIG mRNA expression was detected initially focally in infiltrating neutrophils (15 hours after IA endotoxin) and later in the bronchiolar and peribronchiolar areas and vascular endothelium (1 day after IA endotoxin). In contrast to endotoxin, IA tumor necrosis factor-alpha or interleukin-1 alpha did not induce IP-10 or MIG mRNA in the lung. IA endotoxin also caused a modest induction of IP-10 and MIG mRNA in the jejunum, liver, and spleen. The IP-10 and MIG receptor CXCR3 was detected in the bronchiolar epithelium of preterm lambs by immunostaining. IP-10 and MIG are potent angiostatic chemokines that may contribute to lung injury and altered pulmonary vascular development in the preterm exposed to chorioamnionitis.
Government's assumptions about NHS efficiency savings are optimistic, claims health economist
Authors: C. White
Journal: BMJ (2010)

It is difficult to estimate how much money the NHS in England can save by following a quality and innovation programme set up by the previous Labour government, health economists said at a conference last week. But NHS organisations cannot afford to abandon it, they added.

The quality, innovation, productivity and prevention (QIPP) programme comprises 12 different national work streams, designed to help the NHS do more with less money while still improving quality. The work streams include measures to improve care (such as preventing falls, cutting numbers of infections, and avoiding long term complications) but also innovations in “backroom” functions …
A serological marker for neonatal lupus erythematosus
Authors: W.L. WESTON, CATHERINE HARMON, CAROL PEEBLESs, D. MANCHESTER, H.L. FRANCO, J.C. HUFF, D.A. NORRIS
Journal: British Journal of Dermatology (1982)

Journal Article A serological marker for neonatal lupus erythematosus Get access W.L. WESTON, W.L. WESTON Department of Dermatology, University of Colorado School of Medicine, Denver, Colorado, U.S.A. William L.Weston, M.D., University of Colorado School of Medicine, Department of Dermatolo gy/Box B153. 4200 East Ninth Avenue, Denver, CO 80262, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar CATHERINE HARMON, CATHERINE HARMON Department of Rheumatology, University of Colorado School of Medicine, Denver, Colorado, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar CAROL PEEBLES§, CAROL PEEBLES§ Department of Dermatology, University of Colorado School of Medicine, Denver, Colorado, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar D. MANCHESTER, D. MANCHESTER Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar H.L. FRANCO, H.L. FRANCO Department of Dermatology, University of Colorado School of Medicine, Denver, Colorado, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J.C. HUFF, J.C. HUFF Department of Dermatology, University of Colorado School of Medicine, Denver, Colorado, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar D.A. NORRIS D.A. NORRIS Department of Dermatology, University of Colorado School of Medicine, Denver, Colorado, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 4, 1 October 1982, Pages 377–382, https://doi.org/10.1111/j.1365-2133.1982.tb00380.x Published: 01 October 1982 Article history Accepted: 16 March 1982 Published: 01 October 1982
Unusual Arthritic Manifestations of Hemochromatosis.
Authors: Ralph F. Jacox
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Unusual Arthritic Manifestations of Hemochromatosis.Ralph F. Jacox, M.D., F.A.C.P., C. Douglas Angevine, M.D.Ralph F. Jacox, M.D., F.A.C.P.Search for more papers by this author, C. Douglas Angevine, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-842_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptJoint involvement in hemochromatosis was first recognized by Schumacher (Arthritis Rheum7:41-50, 1964) and further delineated by Hamilton and associates (Quart J Med37:171-182, 1968). Our experience with this disease suggests that any patient with an unusual distribution of arthritis should be investigated for abnormal iron metabolism. One patient with unusual calcific changes around the ankles and with remarkable osteoarthritic disease in the ankle joints was found to have hemochromatosis. He had a high serum iron with 100% saturation and a liver biopsy that showed a heavy deposition of iron characteristic of hemochromatosis. Radiographs of the pelvis showed nodular, bony... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Ralph F. Jacox, M.D., F.A.C.P.; C. Douglas Angevine, M.D.Affiliations: Rochester, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 842-842KeywordsAnklesArthritisBiopsyHemochromatosisLiverPelvis ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
25-Hydroxycholecalciferol absorption in steatorrhoea and postgastrectomy osteomalacia.
Authors: J M Gertner, M Lilburn, M Domenech
Journal: BMJ (1977)

Post-absorption levels of 25-hydroxy vitamin D (25-OHD) after oral administration of 25-hydroxycholecalciferol (25-OHD3) were measured in 11 subjects. Five had presented with steatorrhoea of various causes while six had post-gastrectomy osteomalacia. Post-absorption levels of 25-OHD were low in four of the patients with steatorrhoea but normal in five of those with post-gastrectomy osteomalacia. There was a significant inverse correlation between peak post-absorption 25-OHD levels and faecal fat excretion. All patients with active post-gastrectomy osteomalacia had subnormal baseline plasma 25-OHD levels, which indicates that the condition is due to a deficiency of vitamin D. Only two of the patients with osteomalacia had estimated dietary vitamin D intakes ofer 1-75 microng/day. These findings suggest that an oral 25-OHD absorption test may be a valuable measure of small intestinal function and that poor dietary vitamin D intake rather than impaired absorption of the vitamin may be the major cause of post-gastrectomy osteomalacia.
CASE OF SALIVARY CALCULUS IN WHARTON'S DUCT.
Authors: GAYLORD C. HALL
Journal: JAMA (1907)

Salivary calculi are sufficiently rare to justify reporting the following interesting case: <h3>History.</h3> —C. A. P., aged 22, consulted me Aug. 4, 1907, giving the following history: Trouble began five years previously with pain and swelling on right side of face and neck about angle of jaw. This disappeared by use of astringent washes in a few days. From that time up to one week ago he had always had slight swelling at angle of jaw on right side and some tenderness at all times. This quiescent stage would be interrupted by attacks of swelling and pain which, while always relieved by simple measures, had of late been increasing in number and severity. Patient could offer no explanation for his condition. There was no history of injury and his previous history was negative. Patient was otherwise in good general health. The present attack commenced one week before I saw him,
INTRAVENOUS USE OF DYES
Authors: JOHN W. CHURCHMAN
Journal: JAMA (1925)

When interest in the triphenylmethane group of dyes was reawakened by the studies of their selective powers, reported in 1912 and successive years, the question of their adaptability to intravenous injections immediately arose and (of course, with the ultimate treatment of septicemia in mind) Herz and I,<sup>1</sup>in 1913, studied the fate of gentian violet in the animal body. We showed conclusively that, after intravenous injection, this dye disappeared from the blood stream in about one hour and a quarter. We also made numerous experiments at that time to see whether bacteria floating in the blood stream could be killed by injected dye. The general conclusion of all of this work was stated, in 1924, as follows: "I have never been able to kill organisms circulating in the blood by intra-vascular injection of gentian violet. At the present time there is nothing to suggest that it is now possible
ILLUMINATED FORCEPS AND TENACULUM FOR TONSILLECTOMY AND CONTROL OF HEMORRHAGE
Authors: George R. Marshall
Journal: JAMA (1922)

In tonsillectomy there is inconvenience and danger of tonsil hemorrhage. The experienced operator measures full well its gravity. Hemorrhage is comparatively frequent and may be dangerous, so this fact impressed me sufficiently to devise these instruments. They consist of an ordinary tonsil tenaculum and artery forceps, with Cameron lamp attached. Any standard lamp may be used. These instruments have the following advantages: The tonsil fossa, after removal of the tonsil, is sufficiently illuminated to identify the bleeding point. The bleeding point can be grasped accurately with forceps. This instrument facilitates suturing or ligation of the bleeding vessel. It may be used in emergency hemorrhage in the home. It is simple. Joshua Green Building.
Classic Descriptions in Diagnostic Roentgenology
Authors: Charles G. Roland
Journal: JAMA (1965)

These volumes represent a collection of original communications, interspersed with previously unpublished essays on the history of roentgenology, prepared by several eminent radiologists. The editor reproduces photographs of many early investigators, as well as drawings, illustrations of apparatus, facsimiles of letters and other material. The historical essays which salt the text are often interesting, but they are of uneven quality and in some instances primarily anecdotal. However, Historical Notes on X-ray Plates and Film is very well illustrated, as is the History of Radiologic Journals, to single out two contributions.  The editor has painstakingly and laboriously located, selected, and coordinated the material. The illustrations are valuable, the interpretative essays helpful. No one would deny that the collection, translation, and reproduction of original documents is an appropriate occupation for an historian of radiology. On this basis, these books could be valuable reference works, containing much information difficult or impossible to obtain
Similarity of Lateralized Rhythmic Delta Activity to Periodic Lateralized Epileptiform Discharges in Critically Ill Patients
Authors: Nicolas Gaspard, Louis Manganas, Nishi Rampal, Ognen A. C. Petroff, Lawrence J. Hirsch
Journal: JAMA Neurology (2013)

<h3>Importance</h3> The increasing use of continuous electroencephalography (EEG) monitoring in the intensive care unit has led to recognition of new EEG patterns that are of unclear or unknown significance. <h3>Objective</h3> To describe an EEG pattern, lateralized rhythmic delta activity (LRDA), encountered in critically ill subjects and determine its clinical significance in this setting. <h3>Design, Setting, and Participants</h3> Retrospective review at an academic medical center of EEG recordings, medical records, and imaging studies of critically ill patients with LRDA and comparison with subjects with lateralized periodic discharges (also known as periodic lateralized epileptiform discharges), subjects with focal nonrhythmic slowing, and controls. <h3>Intervention</h3> Electroencephalography or continuous electroencephalography. <h3>Main Outcomes and Measures</h3> Cross-sectional prevalence of lateralized rhythmic delta activity; EEG characteristics; etiology, clinical, and radiological correlates; and risk of early seizures. <h3>Results</h3> We identified LRDA in 4.7% of acutely ill subjects undergoing EEG or continuous EEG monitoring. It was often associated with other focal EEG abnormalities, including lateralized periodic discharges in 44% of cases. The most common conditions associated with LRDA were intracranial hemorrhage and subarachnoid hemorrhage. Lateralized rhythmic delta activity was an independent predictor of acute seizures, with 63% of subjects having seizures during their acute illness, a proportion similar to subjects with lateralized periodic discharges (57%) and significantly higher than associated with focal nonrhythmic slowing (20%) or in control subjects (16%). Most patients (80%-90%) in the LRDA and lateralized periodic discharges groups who had seizures while undergoing continuous EEG monitoring had only nonconvulsive seizures, whereas this was the case for only 17% of patients in the other groups. Lateralized rhythmic delta activity and lateralized periodic discharges were both associated with lesions involving the cortex or juxtacortical white matter. <h3>Conclusions and Relevance</h3> Lateralized rhythmic delta activity in critically ill patients has a similar clinical significance as lateralized periodic discharges. It reflects the presence of a focal lesion and is associated with a high risk of acute seizures, especially nonconvulsive.
Conceptualizing Physician Professionalism
Authors: Eric Walsh
Journal: JAMA (2011)

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Hypertension reduces the number of beta-adrenergic receptors in rat brain microvessels.
Authors: M S Magnoni, H Kobayashi, A Cazzaniga, F Izumi, P F Spano, M Trabucchi
Journal: Circulation (1983)

Beta-adrenergic receptor function was measured in cerebral microvessels of spontaneously and DOCA-salt hypertensive rats using 125I-iodohydroxybenzylpindolol (IHYP). Both in genetic and in experimental hypertension, a significant decrease in the number of beta-receptor sites was observed, without receptor affinity changes. These results suggest that alterations of central adrenergic regulation of small vessels may participate in the pathogenetic mechanisms leading to the development of the central hypertensive disease.
Sensitivity of cat papillary muscles to verapamil and nifedipine: enhanced effect in acidosis
Authors: M. G BRISCOE, H. J SMITH
Journal: Cardiovascular Research (1982)

The effects of acidosis on the myocardial sensitivity to verapamil and nifedipine were examined by measuring the changes in tension in cat papillary muscles perfused in oxygenated physiological saline. Calcium concentration was altered over a range of 2 to 12 mmol . litre-1 and pH adjusted to 7.4, 6.8 or 6.0. Addition of verapamil or nifedipine moved the calcium dose response to the right. At pH 7.4 a Schild plot confirmed competitive interaction between verapamil and calcium, with a calculated dissociation constant (KB) for verapamil of 4.6 +/- 0.2 micrograms . cm-3. At pH 6.0 the slope was less than 1.0 (not significant, P = 0.2) but KB was significantly lower (P less than 0.01) at 0.62 +/- 0.4 microgram . cm-3. Similar enhancement of sensitivity by lowered pH was found for nifedipine. It is proposed that partial inhibition of the slow channel by acidosis increases the sensitivity to calcium entry blockers. This might create a differential effect between normal and diseased tissue in vivo.
Social coping strategies associated with quality of life decrements among psoriasis patients
Authors: S.R. Rapp, C.A. Cottrell, M.R. Leary
Journal: British Journal of Dermatology (2001)

Background Individuals with psoriasis often report significant psychological distress, physical disability, social strain and reduced quality of life. Little is known about how they cope with the illness. Objective The primary aim of this study is to determine whether patients' efforts to cope with psoriasis are associated with better or worse health-related quality of life (HRQL). Methods Focus groups identified seven commonly used coping strategies that were subsequently measured, along with HRQL and other variables, in a survey of 318 individuals with psoriasis. Results Results revealed: (i) that psoriasis is associated with decrements in all quality of life domains that were assessed, and (ii) that commonly used coping strategies such as telling others about psoriasis, covering the lesions and avoiding people were associated with greater decrements in HRQL after controlling for covariates; however, telling others that psoriasis is not contagious was associated with smaller HRQL decreases. Conclusions How patients cope with the social aspects of psoriasis is associated with their quality of life.