tbuckley/cabot-search huggingface dataset:
Complement cleavage products in the phototoxic reaction of porphyria cutanea tarda
Authors: P.D. PIGATTO, M.M. POLENGHI, G.F. ALTOMARE, A. GIACCHETTI, R. CIRILLO, A.F. FINZI
Journal: British Journal of Dermatology (1986)

We have measured C3, C4, CH50 and complement cleavage products C3a and C5a in sera and plasma from PCT patients and normal controls 10 min and I, 4 and 24 h after UVA irradiation. We found elevated C3a concentrations in PCT patients immediately after UVA irradiation and 24 h later. The same was true for CH50, whereas C3, C4 and C5a did not change significantly. No such changes occurred in normal controls. Our data suggest that activation of the complement cleavage product C3 a by porphyrin and UV light triggers a series of events that cause tissue damage.
De subitaneis mortibus. XIV. Bacterial arteritis in Whipple's disease.
Authors: T N James, W S Haubrich
Journal: Circulation (1975)

Although Whipple's disease is clinically recognized for its features of arthritis and diarrhea, pericarditis and cardiac valvular disease are frequently present and a significant number of such patients die suddenly and unexpectedly. This report includes special postmortem cardiovascular examinations in a 55-year-old man who died of Whipple's disease. Pericarditis and valvular disease were extensively present. There was also focal myocardial degeneration, including the sinus node, A-V node and His bundle. Typical Schiff-positive bacilli were found in the tunica media and endothelium most numerously in the small coronary and hepatic arteries, less in splenic and renal arteries, and least in small pulmonary arteries. Large coronary arteries and the aorta were not involved. Three stages of bacterial invasion of the arteries included a noninflammatory phase in which the bacilli were most numerous, a pancreatic phase in which bacilli were distinctly less numerous, and a healed scarring of arteries previously damaged. The combination of pericarditis, valvular disease of the heart, coronary and systemic bacterial arteritis and focal myocardial degeneration and myocarditis is unusual for Whippl'e disease. Studies of other cases are warranted to determine whether bacterial arteriopathy and arteritis have previously been overlooked or if the present case is unique. Evidence that the conduction system of the heart may be involved indicated that careful attention to cardiac rhyth and conduction is merited in future studies of patients with Whipple's disease.
Spectrophotometric Modification of the TAMe Assay for "Prothrombin"
Authors: Dorothy A. Hough, Lillian V. Lyons, Johannes L. Koppel, John H. Olwin
Journal: JAMA (1964)

The purpose of this communication is to describe a new prothrombin assay and to report results of its use in the control of anticoagulant therapy in 1,414 patients. The assay is a spectrophotometric modification of the original TAMe procedure and is based on the esterolytic action of thrombin on p-tosyl-l-arginine methyl ester (TAMe). The assay was performed in parallel with the one-stage, two-stage, and Thrombotest assays in patients during anticoagulant therapy induction, maintenance (long and short-term), and recovery periods, the results closely paralleling those of the two-stage procedure. Because of (1) the uniform reproducibility of its results, (2) the simplicity with which it can be performed, and (3) its ready adaptability to routine clinical use, the authors have found it the most satisfactory prothrombin assay they have used.
Pneumococcal Vaccine and Isolates for the Centers for Disease Control
Authors: Margaret J. Oxtoby, Claire V. Broome, Richard R. Facklam, Robert C. Good
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 April 1986Pneumococcal Vaccine and Isolates for the Centers for Disease ControlMARGARET J. OXTOBY, M.D., CLAIRE V. BROOME, M.D., RICHARD R. FACKLAM, Ph.D., ROBERT C. GOOD, Ph.D.MARGARET J. OXTOBY, M.D.Search for more papers by this author, CLAIRE V. BROOME, M.D.Search for more papers by this author, RICHARD R. FACKLAM, Ph.D.Search for more papers by this author, ROBERT C. GOOD, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-4-587_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We want to emphasize that the Centers for Disease Control (CDC) continues to welcome isolates ofStreptococcus pneumoniaefrom persons who have previously received the pneumococcal vaccine (either the 14- or 23-valent formulation). Two groups of pneumococcal isolates are serotyped at the CDC. The first group consists of isolates from all patients with invasive pneumococcal disease; these isolates are sent in regularly by hospitals participating in the national pneumococcal surveillance system. This representative sample of isolates provides information on serotype distribution. The second group consists of isolates from vaccinated persons; a few of these are from the...Reference1. BOLANBROOMEFACKLAMPLIKAYTISFRASERSCHLECH GCRBDW. Pneumococcal vaccine efficacy in selected populations in the United States. Ann Intern Med. 1986;104:1-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1986Volume 104, Issue 4Page: 587-587KeywordsPneumoniaStreptococcusVaccines Issue Published: 1 April 1986 PDF DownloadLoading ...
IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia
Authors: Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Tomoyoshi Soga, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
Journal: Cancer Research (2015)

IDH1 and IDH2 mutations occur frequently in acute myeloid leukemia (AML) and other cancers. The mutant isocitrate dehydrogenase (IDH) enzymes convert α-ketoglutarate (α-KG) to the oncometabolite 2-hydroxyglutarate (2-HG), which dysregulates a set of α-KG-dependent dioxygenases. To determine whether mutant IDH enzymes are valid targets for cancer therapy, we created a mouse model of AML in which mice were transplanted with nucleophosmin1 (NPM)(+/-) hematopoietic stem/progenitor cells cotransduced with four mutant genes (NPMc, IDH2/R140Q, DNMT3A/R882H, and FLT3/ITD), which often occur simultaneously in human AML patients. Conditional deletion of IDH2/R140Q blocked 2-HG production and maintenance of leukemia stem cells, resulting in survival of the AML mice. IDH2/R140Q was necessary for the engraftment or survival of NPMc(+) cells in vivo. Gene expression analysis indicated that NPMc increased expression of Hoxa9. IDH2/R140Q also increased the level of Meis1 and activated the hypoxia pathway in AML cells. IDH2/R140Q decreased the 5hmC modification and expression of some differentiation-inducing genes (Ebf1 and Spib). Taken together, our results indicated that IDH2 mutation is critical for the development and maintenance of AML stem-like cells, and they provided a preclinical justification for targeting mutant IDH enzymes as a strategy for anticancer therapy.
David Hugh Gilmore
Authors: A. Cameron
Journal: BMJ (2002)

Consultant obstetrician and gynaecologist Queen Mother's Hospital and Western Infirmary (b Ayrshire 1953; q Glasgow 1977; MD, FRCOG, FRCS Glas), died from a heart attack on 15 March 2002.

In 1988 he was appointed to his first consultant post at the Royal Alexandra Infirmary, Paisley, moving to the Queen Mother's and Western Infirmary in 1995. David was a true “all rounder.” His involvement with junior staff training led to him being elected regional RCOG adviser in 1999. Trainees found him to be a demanding but inspirational figure. He leaves a partner, Jess; and two sons.
Abstract 3682: Overexpression and cell proliferation-regulating function of CRKL protein in gastric cancer
Authors: Hiroko Natsume, Kazuya Shinmura, Hong Tao, Masaya Suzuki, Masanori Goto, Hidetaka Yamada, Matsuyoshi Maeda, Hiroyuki Konno, Satoki Nakamura, Haruhiko Sugimura
Journal: Cancer Research (2012)

Abstract Genomic DNA amplification is a genetic factor involved in cancer, and some oncogenes, such as ERBB2, are highly amplified in gastric cancer. To identify previously undiscovered amplified genes in gastric cancer, a genome-wide single nucleotide polymorphism microarray analysis was performed using three cell lines of differentiated gastric cancers. Twenty-two genes (including ERBB2) in five highly amplified chromosome regions (with a copy number of more than 6) were identified. Particular attention was paid to the CRKL gene, which has not been previously characterized in gastric cancer and the product of which is an adaptor protein containing Src homology 2 and 3 (SH2/SH3) domains. A relatively high CRKL copy number was confirmed in the MKN74 gastric cancer cell line using fluorescence in situ hybridization, and a high level of CRKL expression was also observed in the cells. The RNA-interference-mediated knockdown of CRKL in MKN74 disclosed the ability of CRKL to upregulate gastric cell proliferation. An immunohistochemical analysis revealed that CRKL protein was overexpressed in 24.4% (88/360) of the primary gastric cancers that were analyzed. Finally, we showed that MKN74 cells with CRKL amplification were responsive to the dual Src/BCR-ABL kinase inhibitor BMS354825, likely via the inhibition of CRKL phosphorylation, and that the proliferation of MKN74 cells was suppressed by treatment with a CRKL-targeting peptide. These results suggested that CRKL protein is overexpressed in a subset of gastric cancers, that it regulates gastric cell proliferation, and that it has the potential to be a molecular therapy target for gastric cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3682. doi:1538-7445.AM2012-3682
Binding specificity of serum amyloid P component for the pyruvate acetal of galactose.
Authors: C R Hind, P M Collins, D Renn, R B Cook, D Caspi, M L Baltz, M B Pepys
Journal: The Journal of Experimental Medicine (1984)

Serum amyloid P component (SAP) is a normal plasma protein that is of interest because of its presence in amyloid deposits, its presence in normal human glomerular basement membrane, and its stable evolutionary conservation. It has calcium-dependent ligand-binding specificity for amyloid fibrils, fibronectin (Fn), C4-binding protein (C4bp), and agarose. Although the binding to agarose, a linear galactan hydrocolloid derived from some marine algae, is unlikely per se to be related to the physiological function of SAP, it does provide a model system in which to explore the precise ligand requirements of SAP. We report here that the amount of SAP from human, mouse, and plaice (Pleuronectes platessa L.) serum able to bind to agarose from different sources reflect precisely their pyruvate content. Methylation with diazomethane of the carboxyl groups in the pyruvate moiety of agarose completely abolishes SAP binding to agarose. The pyruvate in agarose exists as the 4,6-pyruvate acetal of beta-D-galactopyranose. We have therefore synthesized this galactoside, using a novel procedure, established its structure by analysis of its nuclear magnetic resonance spectra, and shown that it completely inhibits all known calcium-dependent binding reactions of SAP. The R isomer of the cyclic acetal, methyl 4,6-O-(1-carboxyethylidene)-beta-D-galactopyranoside (MO beta DG) was effective at millimolar concentration and was more potent than its noncyclic analogue, while pyruvate, D-galactose, and methyl beta-D-galactopyranoside were without effect. The autologous protein ligands of SAP presumably, therefore express a structural determinant(s) that stereochemically resembles MO beta DG. Availability of this specific, well-characterized, low molecular weight ligand for SAP should facilitate further investigation of the function of SAP and its role in physiological and pathophysiological processes.
Reviews and Notes: On the Ledge: A Doctor's Stories from the Inner City
Authors: Rita Charon
Journal: Annals of Internal Medicine (1996)

Literature of Medicine15 October 1996Reviews and Notes: On the Ledge: A Doctor's Stories from the Inner CityRita Charon, MDRita Charon, MDColumbia University, New York, NY 10032Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-8-199610150-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail NS Skolnik. 161 pages. Boston: Faber and Faber; 1996. $19.95. ISBN 0-571-19883-X. Order phone 800-666-2211.A family physician works in an inner-city government-subsidized clinic treating patients with tuberculosis, substance abuse problems, syphilis, injuries from domestic violence, unwanted pregnancies, the acquired immunodeficiency syndrome, and failure to thrive. The physician, too, fails to thrive. His anger toward his not-altogether-blameless patients, his undue pessimism alternating with delusions of grandeur, and his corrupting cynicism prove to be too much. After 2 years, he leaves the clinic, his guilt compounded when he learns that the entire clinic will be closed once he is gone.Rather ... Author, Article, and Disclosure InformationAffiliations: Columbia University, New York, NY 10032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1996Volume 125, Issue 8Page: 702KeywordsAIDSChildrenDomestic violenceDrug regulationDrugsEmotionsFemale contraceptionPregnancySubstance abuseSyphilis ePublished: 15 August 2000 Issue Published: 15 October 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Modification of Neisser's Diagnostic Stain for the Diphtheria Bacillus
Authors: A. C. Coles
Journal: BMJ (1899)

UDtLnJAL 1213 lung, in that there can be no eroding pressure on any large vessel, and also because it is not liable to extrusion, as so frequently happens with drainage tubes in thoracic surgery.Fortunately the lung was adherent to the costal pleura, and thus what might have been a very difficult operation was much simplified.Finally, although the consideration is of quite secondary importance, one need not in children, as the later photograph (Fig 2) (taken July 22nd, four and a half months after operation) illustrates, be deterred from excising considerable portions of ribs by the fear of future deformity, an observation which strictly applies also to the surgical treatment of empyema.
A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5
Authors: Marina Bousquet, Cyril Broccardo, Cathy Quelen, Fabienne Meggetto, Emilienne Kuhlein, Georges Delsol, Nicole Dastugue, Pierre Brousset
Journal: Blood (2006)
European flu toll reaches 107 confirmed cases
Authors: R. Watson
Journal: BMJ (2009)

<h3>Abstract</h3> Adult hippocampal neurogenesis occurs throughout life and is believed to participate in cognitive functions such as learning and memory. A number of genes that regulate adult hippocampal neurogenesis have been identified, although most of these have been implicated in progenitor proliferation and survival, but not in the development into fully differentiated neurons. Among these genes, apolipoprotein E (ApoE) is particularly compelling because the human ApoE isoform E4 is a risk factor for the development of Alzheimer’s disease, where hippocampal neurogenesis is reported to be dysfunctional. To investigate the effects of ApoE and its human isoforms on adult hippocampal neurogenesis and neuronal development, retroviruses carrying a GFP-expressing vector were injected into wild-type (WT), ApoE-deficient, and human targeted replacement (ApoE3 and ApoE4) mice to infect progenitors in the dentate gyrus and analyze the morphology of fully developed GFP-expressing neurons. Analysis of these adult-born neurons revealed significant decreases in the complexity of dendritic arborizations and spine density in ApoE-deficient mice compared with WT mice, as well as in ApoE4 mice compared with ApoE3. These findings demonstrate that ApoE deficiency and the ApoE4 human isoform both impair hippocampal neurogenesis and give insight into how ApoE may influence hippocampal-related neurological diseases.
ER blamed for nursing shortage
Authors: J. Lenzer
Journal: BMJ (2003)

The top rated television show ER , now in its tenth season, is the target of a letter writing campaign by nurses who say that the show's depiction of them is demeaning. Such a negative portrayal, they say, is contributing to the critical shortage of nurses in the United States.

The show is wildly popular with audiences around the world. Twenty million US viewers alone tune in every week to watch, for example, patients with gunshot wounds or terminal cancer, or wealthy hypochondriacs pouring in through the doors of a level one trauma hospital in Chicago. The care of patients in ER always triggers ethical conundrums. Tempers flare. Doctors clash. In the end, the right thing is not always done.

The issues that the show tackles have long made it a target of advocacy groups. Anti-vaccination campaigners and advocates for blind people have protested about segments of ER . Now nurses are …
Using Medicare Data to Understand Health Care Value
Authors: Philip A. Band
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Public health consequences of heavy metals in dump sites.
Authors: T W Clarkson, B Weiss, C Cox
Journal: Environmental Health Perspectives (1983)

Metals differ from most synthetic organic chemicals in that their clinical manifestations are well known and methods for their measurement in the body are generally well established. Since metals are ubiquitous, special care should be taken to identify the source, whether dump site or not. Isotopic ratios may be used for lead. Time of exposure may be highly variable so estimates will be necessary of integrated
Type IV Hyperlipoproteinemia
Authors: Robert Zelis, Ezra A. Amsterdam, James F. Spann, Dean T. Mason
Journal: JAMA (1972)

Since weight reduction, the cornerstone of treatment in type IV hyperlipoproteinemia, has poor patient acceptance, clofibrate (2 gm/day) was evaluated in a double-blind study prior to dietary therapy in 12 patients. Mean plasma triglyceride levels fell with clofibrate (429 mg/100 ml to 255 mg/100 ml) but not with placebo (565 mg/100 ml). In most patients, cholesterol levels were unchanged. Although clofibrate alone may be effective in certain type IV patients if both cholesterol and triglyceride levels are substantially reduced, it is no substitute for adequate dietary therapy.
Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival
Authors: Sotiria Sotiriou, Suzana Gispert, Jun Cheng, Yaohui Wang, Amy Chen, Shelley Hoogstraten-Miller, Georgina F. Miller, Oran Kwon, Mark Levine, Susan H. Guttentag, Robert L. Nussbaum
Journal: Nature Medicine (2002)
Labouring in water:Findings do not fully support conclusions
Authors: Helen Bradshaw
Journal: BMJ (2004)

EDITOR—The study by Cluett et al, comparing labour in water with standard augmentation for dystocia, tackles an important area.1 Too often modern obstetrics concentrates on major medical interventions and neglects the low tech solutions that many women would prefer.2

Despite the study's robust design the findings do not fully …
17 SMALL INTERFERING RNA INHIBIT WOODCHUCK HEPATITIS VIRUS GENE EXPRESSION AND REPLICATION IN PRIMARY HEPATOCYTES AND RESTORE THE CELLULAR ANTIVIRAL GENE EXPRESSION
Authors: Z.J. Meng, S. Qiu, X.Y. Zhang, J. Wu, T. Schreiter, Y. Xu, D.L. Yang, M. Roggendorf, J. Schlaak, M.J. Lu
Journal: Journal of Hepatology (2008)
The FDA and Drug Uses: Reprise-Reply
Authors: John Archer
Journal: JAMA (1985)

In Reply.—  I appreciate Dr Nightingale's letter and agree with everything he has stated. The letter does much to clarify and expand on what I said in my editorial. Although I was thinking in a somewhat different context about FDA  of uses of drugs, Dr Nightingale's explanation of how the agency does sometimes validly express  of some uses of some drugs should prove valuable to readers. As noted in the editorial, however, on some occasions labeling has, in a sense, expressed disapproval of valid uses of drugs as I specified.
Primary Care Physician Workforce and Outcomes—Reply
Authors: Chiang-Hua Chang, Therese A. Stukel, David C. Goodman
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal