tbuckley/cabot-search huggingface dataset:
Demeclocycline Treatment in the Syndrome of Inappropriate Antidiuretic Hormone Secretion
Authors: DAVID A. CHERRILL
Journal: Annals of Internal Medicine (1975)

We have studied the effects of demeclocycline on the water metabolism of a patient with the syndrome of inappropriate antidiuretic hormone (ADH) secretion who presented with a serum sodium concentration of 110 meq/litre. Free water clearance was studied before, during, and after treatment with demeclocycline. This study shows that demeclocycline (900 mg/day) can at least partially inhibit the action of ADH in the setting of tumor-induced ADH secretion, with the production of a reversible, partial nephrogenic diabetes insipidus, and with few or no side effects. Demeclocycline may be useful in the treatment of chronic inappropriate ADH secretion.
Hospital Care and Medical Utilization After Discharge
Authors: Arun K. Raman
Journal: Annals of Internal Medicine (2011)

Letters15 November 2011Hospital Care and Medical Utilization After DischargeArun K. Raman, MD, MPHArun K. Raman, MD, MPHFrom Endion Hospitalist Systems: A Cogent HMG Company, Buffalo, NY 14221.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-10-201111150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As a practicing hospitalist, I agree with Kuo and Goodwin's findings (1) that seamless PCP-driven inpatient care is efficient and cost-effective. As noted in the article, hospitalized patients cared for by hospitalists cost Medicare $282 less during their hospital stay and $332 more after their discharge than hospitalized patients cared for by PCPs; these data imply a cost shift of approximately $50. If this shift were applied to 25% of patients using Medicare who were hospitalized, the annual additional cost would be $170 million, not $1.1 billion as the authors stated.The intensity of care that hospitalized ...References1. Kuo YF, Goodwin JS. Association of hospitalist care with medical utilization after discharge: evidence of cost shift from a cohort study. Ann Intern Med. 2011;155:152-9. [PMID: 21810708] LinkGoogle Scholar2. Centers for Medicare & Medicaid Services. 100% MEDPAR inpatient hospital fiscal year 2008. Short stay inpatient by state. Accessed at www.cms.gov/MedicareFeeforSvcPartsAB/Downloads/DRGState08.pdf on 12 May 2010. Google Scholar Author, Article, and Disclosure InformationAuthors: Arun K. Raman, MD, MPHAffiliations: From Endion Hospitalist Systems: A Cogent HMG Company, Buffalo, NY 14221.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssociation of Hospitalist Care With Medical Utilization After Discharge: Evidence of Cost Shift From a Cohort Study Yong-Fang Kuo and James S. Goodwin Hospital Care and Medical Utilization After Discharge Dimitriy Levin and Jeffrey J. Glasheen Hospital Care and Medical Utilization After Discharge Joshua Freeman Hospital Care and Medical Utilization After Discharge Yong-Fang Kuo and James S. Goodwin Hospital Care and Medical Utilization After Discharge David M. Mitchell Hospital Care and Medical Utilization After Discharge David O. Meltzer and Jeanette W. Chung Hospital Care and Medical Utilization After Discharge Jean-Sebastien Rachoin Hospital Care and Medical Utilization After Discharge Daniel J. Brotman , Romsai T. Boonyasai , and Amy Deutschendorf Metrics Cited byCharacteristics of primary care providers who adopted the hospitalist model from 2001 to 2009 15 November 2011Volume 155, Issue 10Page: 721KeywordsCohort studiesConflicts of interestForecastingHospitalistsInpatientsMedicareNursing homesPatients ePublished: 15 November 2011 Issue Published: 15 November 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Unusual Collateral Venous Blood Flow Following Surgical Repair of a Thoracic Aortic Dissection
Authors: LAWRENCE C. SWAYNE, HAL N. GINSBERG, GRANT V. S. PARR
Journal: Clinical Nuclear Medicine (1991)

We present a case of unusual collateral venous blood flow, which occurred following proximal surgical repair of an extensive type A thoracic aortic dissection. Although no major veins were ligated during surgery, the procedure resulted in a functional obstruction of the left brachiocephalic vein. Possible etiologies for the venous obstruction include intrinsic effects (e.g., direct trauma from surgical retraction) or extrinsic effects (e.g., compression from postoperative swelling and edema). Incidentally noted was nonvisualization of the right kidney secondary to involvement of the right renal artery by the false channel of the aortic dissection. This case illustrates the potential value of scintiangiography for the evaluation of venous blood flow patterns following major vascular surgery in the thorax.
Intravenous Ergometrine for Retained Placenta
Authors: J. C. Moir
Journal: BMJ (1947)

The Indian Medical Service SIR,-In the course of last week the Indian Medical Service as a service of the Crown passed away.With the other Indian Services it has received a vote of thanks from both Houses of Parliament.To the general public at home, the Indian Medical Service was a vague entity which had produced some famous men, but what it did for India is little realized even by medical men in this country.Those of us who saw the work of that great service know that its credit rests not only on those of its members whose reputations were international, but on many others unknown in Britain whose names were household words in vast tracts of India.The debt India owes to the Indian Medical Service is beyond calculation, and we, whose medical schools produced so many of its members, should place on record some account of its achievements and the appreciation of the medical profession.-Iam, etc.,
Letter: Congenital defects of the anterior abdominal wall.
Authors: D W Ryan
Journal: BMJ (1975)

with the same antigen since our source of material is the same.Hopefully, co-operative and collaborative efforts will accelerate the eventual realization of an effective human vaccine to protect against malaria.The pro- cess of achieving this end should not be exacerbated by deliberate or inadvertent downgrading or misrepresen,tation.
Sequence heterogeneities among 16S ribosomal RNA sequences, and their effect on phylogenetic analyses at the species level
Authors: V. Cilia, B. Lafay, R. Christen
Journal: Molecular Biology and Evolution (1996)

We have analyzed what phylogenetic signal can be derived by small subunit rRNA comparison for bacteria of different but closely related genera (enterobacteria) and for different species or strains within a single genus (Escherichia or Salmonella), and finally how similar are the ribosomal operons within a single organism (Escherichia coli). These sequences have been analyzed by neighbor-joining, maximum likelihood, and parsimony. The robustness of each topology was assessed by bootstrap. Sequences were obtained for the seven rrn operons of E. coli strain PK3. These data demonstrated differences located in three highly variable domains. Their nature and localization suggest that since the divergence of E. coli and Salmonella typhimurium, most point mutations that occurred within each gene have been propagated among the gene family by conversions involving short domains, and that homogenization by conversions may not have affected the entire sequence of each gene. We show that the differences that exist between the different operons are ignored when sequences are obtained either after cloning of a single operon or directly from polymerase chain reaction (PCR) products. Direct sequencing of PCR products produces a mean sequence in which mutations present in the most variable domains become hidden. Cloning a single operon results in a sequence that differs from that of the other operons and of the mean sequence by several point mutations. For identification of unknown bacteria at the species level or below, a mean sequence or the sequence of a single nonidentified operon should therefore be avoided. Taking into account the seven operons and therefore mutations that accumulate in the most variable domains would perhaps increase tree resolution. However, if gene conversions that homogenize the rRNA multigene family are rare events, some nodes in phylogenetic trees will reflect these recombination events and these trees may therefore be gene trees rather than organismal trees.
An Official American Thoracic Society/European Respiratory Society Statement: Research Questions in Chronic Obstructive Pulmonary Disease
Authors: Bartolome R. Celli, Marc Decramer, Jadwiga A. Wedzicha, Kevin C. Wilson, Alvar Agustí, Gerard J. Criner, William MacNee, Barry J. Make, Stephen I. Rennard, Robert A. Stockley, Claus Vogelmeier, Antonio Anzueto, David H. Au, Peter J. Barnes, Pierre-Regis Burgel, Peter M. Calverley, Ciro Casanova, Enrico M. Clini, Christopher B. Cooper, Harvey O. Coxson, Daniel J. Dusser, Leonardo M. Fabbri, Bonnie Fahy, Gary T. Ferguson, Andrew Fisher, Monica J. Fletcher, Maurice Hayot, John R. Hurst, Paul W. Jones, Donald A. Mahler, François Maltais, David M. Mannino, Fernando J. Martinez, Marc Miravitlles, Paula M. Meek, Alberto Papi, Klaus F. Rabe, Nicolas Roche, Frank C. Sciurba, Sanjay Sethi, Nikos Siafakas, Don D. Sin, Joan B. Soriano, James K. Stoller, Donald P. Tashkin, Thierry Troosters, Geert M. Verleden, Johny Verschakelen, Jorgen Vestbo, John W. Walsh, George R. Washko, Robert A. Wise, Emiel F. M. Wouters, Richard L. ZuWallack
Journal: American Journal of Respiratory and Critical Care Medicine (2015)

Section:ChooseTop of pageAbstract <<Executive SummaryContentsIntroductionMethodsDefinitionsClinical Presentation and...DiagnosisAssessment after Diagnosi...Pathophysiology and Patho...ManagementConclusionsReferencesCITING ARTICLES
The short-term impact of a continuing medical education program on providers' attitudes toward treating diabetes.
Authors: L K Sharp, M S Lipsky
Journal: Diabetes Care (1999)

OBJECTIVE: The objective of this study was to evaluate the short-term impact of a 7-h type 2 diabetes continuing medical education (CME) program. Outcomes included a measure of health care providers' diabetes knowledge and the Diabetes Attitude Scale (DAS), a validated measure of attitudes toward diabetes. RESEARCH DESIGN AND METHODS: A CME program on type 2 diabetes was presented by an expert panel in Chicago during November 1998. A before-after trial with pre- and postintervention measurements of diabetes knowledge and attitudes toward diabetes was administered as part of the program. A convenience sample of the 129 health care providers in attendance resulted in 91 (71%) completed pre- and postintervention surveys. RESULTS: Within-subjects analysis revealed increases in knowledge and more favorable attitudes toward diabetes after the program. Between-subjects analysis revealed that attitude changes differed for physicians as compared with allied health care providers. CONCLUSIONS: A CME program was associated with an increase in knowledge of diabetes and more favorable attitudes toward diabetes as measured by the DAS. The DAS changes were subtly different for the physician group as compared with the allied health care provider group. These results suggest that the DAS can be a useful instrument for measuring the short-term impact of educational interventions.
IMWG consensus on risk stratification in multiple myeloma
Authors: W J Chng, A Dispenzieri, C-S Chim, R Fonseca, H Goldschmidt, S Lentzsch, N Munshi, A Palumbo, J S Miguel, P Sonneveld, M Cavo, S Usmani, B GM Durie, H Avet-Loiseau
Journal: Leukemia (2013)
Drug Use Data: A Different Perspective
Authors: Armistead M. Lee
Journal: JAMA (1975)

IT IS AN occupational hazard of advocates to overstate the size of the problems their innovations might correct and the benefits of their proposed solutions. The average physician makes due allowance for such possible bias when listening to a pharmaceutical company's sales representative. However, he may not be equally aware of the same potential for bias when listening to the advocate of some new proposal for upgrading the quality and rationality of health care.  One such advocate is T. Donald Rucker, PhD. In an article 1 inThe Journal, Dr. Rucker proposed a computerized drug information system that would provide, among other benefits, a means for ongoing peer review of medications prescribed.  To oppose utilization review in any form is equivalent to attacking motherhood. It is an idea that has been widely accepted in principle and applied in practice for many years, as any member of a hospital tissue committee
Estimated Effects of Projected Climate Change on the Basic Reproductive Number of the Lyme Disease Vector <i>Ixodes scapularis</i>
Authors: Nicholas H. Ogden, Milka Radojevic´, Xiaotian Wu, Venkata R. Duvvuri, Patrick A. Leighton, Jianhong Wu
Journal: Environmental Health Perspectives (2014)

The extent to which climate change may affect human health by increasing risk from vector-borne diseases has been under considerable debate.We quantified potential effects of future climate change on the basic reproduction number (R0) of the tick vector of Lyme disease, Ixodes scapularis, and explored their importance for Lyme disease risk, and for vector-borne diseases in general.We applied observed temperature data for North America and projected temperatures using regional climate models to drive an I. scapularis population model to hindcast recent, and project future, effects of climate warming on R0. Modeled R0 increases were compared with R0 ranges for pathogens and parasites associated with variations in key ecological and epidemiological factors (obtained by literature review) to assess their epidemiological importance.R0 for I. scapularis in North America increased during the years 1971-2010 in spatio-temporal patterns consistent with observations. Increased temperatures due to projected climate change increased R0 by factors (2-5 times in Canada and 1.5-2 times in the United States), comparable to observed ranges of R0 for pathogens and parasites due to variations in strains, geographic locations, epidemics, host and vector densities, and control efforts.Climate warming may have co-driven the emergence of Lyme disease in northeastern North America, and in the future may drive substantial disease spread into new geographic regions and increase tick-borne disease risk where climate is currently suitable. Our findings highlight the potential for climate change to have profound effects on vectors and vector-borne diseases, and the need to refocus efforts to understand these effects.
Topics in Gastroenterology: 2
Authors: Howard M. Spiro
Journal: JAMA (1975)

Somehow, British writers and publishers can turn out quickly and effectively engaging and up-to-date books.<i>Topics in Gastroenterology</i>, based on a very recent course in postgraduate gastroenterology at Oxford and with references into 1974, is a small paperbound book about as current as it can be. Fine reading for the general internist and gastroenterologist, its topics range as widely as recent developments in gastrointestinal endoscopy, the synthesis and chemical nature of mucus, and the medical management of ulcerative colitis. Hans Krebs offers a chapter on the metabolism of ethanol which I found particularly helpful. With useful information from every contributor,<i>Topics in Gastroenterology</i>has a maturity that comes with reflection on experience and is no mere literature review. But don't rush out to buy a copy without recognizing that you will pay, in the United States at least, $39.50 for a 373-page softbound book. Its British price is £10, which
Children as Research Subjects: Science, Ethics, and Law
Authors: Robert M. Nelson
Journal: JAMA (1995)

The subject of research involving children is inherently one of contrast. The needs of society are balanced against the rights of the never competent individual. The possible good for many is weighed against the possible harm to one. Parents are asked to consent to their child's undergoing a research protocol as part of treatment by investigators with research projects who may also be parents.<i>Children as Research Subjects</i>, edited by Michael A. Grodin and Leonard H. Glantz, examines the topic of research involving children from these many varied perspectives. The editors have brought together a number of experienced individuals in an attempt to achieve a balanced examination of these complex issues. The volume starts with a historical view of research using children as subjects. This first chapter should be read by all who involve children as research subjects or who have oversight responsibilities for such research. The remainder of the
Suppression of alcohol-induced flushing by a combination of H1 and H2 histamine antagonists
Authors: O.T. TAN, T.J. STAFFORD, I. SARKANY, P.M. GAYLARDE, C. TILSEY, J.P. PAYNE
Journal: British Journal of Dermatology (1982)

Alcohol-induced flushing of the face and neck regions is a well recognized condition, probably genetically determined and due to individual differences in alcohol metabolism. We have shown that the flushing appears only after a threshold level of blood alcohol (20–35 mg per 100 ml) is exceeded. The rate of alcohol absorption and peak blood levels were reduced by a combination of H1 and H2 antagonists. This reduction was accompanied by abolition of flushing in sensitive individuals.
Successful Endoscopic Management of Iatrogenic Mediastinal Infection and Subsequent Esophagomediastinal Fistula, Following Endosonographically Guided Fine-Needle Aspiration Biopsy
Authors: U. Will, F. Meyer, H. Bosseckert
Journal: Endoscopy (2005)

Complications following endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy are rare. A 75-year-old man underwent EUS-FNA biopsy of an enlarged mediastinal lymph, which histologic investigation revealed to be a metastasis of a hepatocellular carcinoma. The patient developed the postinterventional complication of suppurative infection within the mediastinum. Under EUS guidance, a pigtail catheter and a soft tube were inserted to respectively drain and rinse the mediastinal lesion for 8 days. The remaining esophagomediastinal fistula was closed by gathering the fistula margins, using band ligations and an Endoloop. The fistula healed with no further complaints or dysphagia. Infection is a possible complication of endoluminal FNA biopsy. An endoscopically guided therapeutic approach can be favored as the initial treatment of choice and as a reasonable alternative that avoids surgical intervention.
Drug Automatism: A Myth
Authors: Hugh H. Hussey
Journal: JAMA (1974)

Many cases of severe intoxication or death result each year from overdoses of barbiturates. The idea prevails that some of these cases are due to "drug automatism," meaning that a patient takes a dose of a barbiturate, forgets about it, takes another dose, and so on, to the point of intoxication or death, which therefore would be considered "accidental." In a recent issue of the<i>Archives of General Psychiatry</i>(31:216-220, 1974), Dorpat deplores the theory of drug automatism; indeed, he explodes it. To that end, he presents a thorough review of the literature in which he fails to find a single well-authenticated case of drug automatism. He also presents two cases of barbiturate intoxication—one fatal and one nonfatal—in which an initial diagnosis of drug automatism was erroneously made. The first patient, a middle-aged woman, ingested more than 20 barbiturate sleeping pills. Soon thereafter, and by good fortune, her husband found
Uptake of Technetium-99m DISIDA by Bone Metastasis From a Hepatoma
Authors: F PONS, F LOME??A, X CALVET, J BRUIX, A CATAFAU, A. GIN??S, R HERRANZ, J SETOAIN
Journal: Clinical Nuclear Medicine (1988)

Uptake of Tc-99m DISIDA in a bone meiastatis from a hepatoma located at the humeral head is reported. Previous literature has only shown extrahepatic uptake of hepatobiliary agents in cases of lung metastases from hepatocellular carcinoma. The use of imaging with biliary tracers can increase the diagnostic specificity when bone metastases from hepatoma are suspected.
Inhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexes.
Authors: P Romagnoli, R N Germain
Journal: The Journal of Experimental Medicine (1995)

Calnexin is a resident protein of the endoplasmic reticulum (ER) that associates with nascent protein chains. Among the newly synthesized integral membrane proteins known to bind to calnexin is invariant chain (Ii), and Ii release from calnexin coincides with proper assembly with major histocompatibility complex (MHC) class II heterodimers. Although calnexin association with several membrane glycoproteins depends on interactions involving N-linked glycans, we previously reported that a truncation mutant of mouse Ii (mIi1-107) lacking both N-glycosylation sites was highly effective in associating with MHC class II heterodimers and escorting these dimers through the secretory pathway. This could indicate that calnexin, despite binding to both Ii and class II, is not necessary for the proper interaction of these proteins, or that in contrast to most membrane glycoproteins, the N-linked glycans of Ii are not critical to its interaction with this chaperone. To examine this issue, we have directly explored the binding of calnexin to both Ii truncation mutants lacking the typical sites of N-glycosylation or Ii produced in cells treated with tunicamycin to prevent glycan addition. These experiments revealed that either method of eliminating N-linked carbohydrates on Ii also inhibited association with calnexin. A lumenally truncated form of Ii (mIi1-131) that still has N-linked carbohydrates showed a decreased affinity for calnexin compared with intact Ii, however, indicating that calnexin-Ii binding is not determined solely by the sugar moieties. All forms of Ii lacking N-linked sugars and showing defective association with calnexin also had enhanced rates of preendosomal degradation. Despite this effect on degradation rate, tunicamycin treatment did not inhibit the association of class II with glycan-free Ii. These data support the view that calnexin is not an absolute requirement for the proper assembly of class II-Ii nonamers, but rather acts primarily to retain Ii in the ER and to inhibit its degradation. These two properties of calnexin-Ii interaction may help ensure that sufficient intact Ii is available for efficient inactivation of the binding sites of newly synthesized class II molecules, while limiting the ability of excess free Ii to alter the transport properties of the early endocytic pathway.