tbuckley/cabot-search huggingface dataset:
INTESTINAL OBSTRUCTIONS FROM GALLSTONES, WITH REPORT OF A CASE.
Authors: JOHN PRENTISS LORD
Journal: JAMA (1898)

Sunday, March 14, 1898, I was called in consultation to see a man, aged 70 years, who was suffering from acute intestinal obstruction, and suffered from vague gastro-intestinal symptoms for about one year, which had caused him to take medical treatment most of the period, without relief, he had been reduced in general health and strength, although he had maintained a very fair degree of vigor, and had filled his place as clerk uninteruptedly until the previous Thursday, when he was attacked, while at breakfast, with a sudden acute pain in the left side, midway between the umbilicus and the spine of the ileum. He left his breakfast uneaten and went to the office where he continued to suffer from pain and nausea; had an evacuation of the bowels and vomited. At ten o'clock he saw his physician, Dr. Malster, who prescribed and sent him home. The pain did not
Pacing prevention of atrial tachyarrhythmias: preliminary results from the Italian AT500 registry
Authors: GianLuca Botto, Luigi Padeletti, Renato Ricci, Giuseppe Inama, Annibale S. Montenero, Alessandro Capucci, Giuseppe Boriani, Paolo DellaBella, Alessandro Proclemer, Andrea Grammatico
Journal: Journal of the American College of Cardiology (2002)
ADHD Medications and Cardiovascular Risk
Authors: Philip Shaw
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CARDIAC FAILURE SECONDARY TO INEFFECTIVE BELLOWS ACTION OF THE CHEST CAGE
Authors: James A. Feltman, Walter Newman, Arthur Schwartz, Daniel J. Stone, Francis J. Lovelock
Journal: Journal of Clinical Investigation (1952)

The two cases to be presented demonstrate ventilatory insufficiency of the restrictive type due ,in the first instance to primary neuromuscular dysfunction and in the second to chronic pleural disease with resulting calcification and restriction of the underlying parenchyma and diaphragm.Of particular interest was the development of con- gestive heart failure in both of these patients.These cases represent examples of cardiac failure secondary to an ineffective bellows action of the chest cage without significant intrinsic pulmonary disease. CASE REPORTS Case 1This 34 year old white male was well until 1945 when he noted the gradual onset of weakness of the right side of the face.A few months later he began to have bilateral jaw weakness, and difficulty in swallowing food with regurgitation of fluid through the nose.In 1947 there was onset of occasional diplopia.He was admitted to this hospital on three different occasions between January 1947 and November 1948 and on all these admissions showed signs and symptoms of bulbar involvement.These signs and symptoms persisted with little change except for development of dysarthria.In November 1949 he complained of difficulty in maintaining erect posture and he was readmitted for his fourth and final admission.At this time the patient stated he had noted dyspnea on exertion for the preceding one and a half years and dur- ing the month before admission, cyanosis of the lips had
Extended 21-Sample Needle Biopsy Protocol for Diagnosis of Prostate Cancer in 1000 Consecutive Patients
Authors: Guillaume Guichard, Stéphane Larré, Andrea Gallina, Adi Lazar, Hugo Faucon, Stéphanie Chemama, Yves Allory, Jean-Jacques Patard, Dimitri Vordos, Andras Hoznek, René Yiou, Laurent Salomon, Claude Clément Abbou, Alexandre de la Taille
Journal: European Urology (2007)
Haemoglobin-H Disease
Authors: J. P. Bingle, E. R. Huehns, T. A. J. Prankerd
Journal: BMJ (1958)

Haemoglobin-H was first described in 1955 by Rigas, Koler, and Osgood.It differs from the other abnormal haemoglobins so far described in that its inheritance cannot be followed by electrophoresis in its heterozy- gous and homozygous forms.Usually in the haemo- globinopathies, adult haemoglobin (HbA) and the abnormal haemoglobin are present in approximately equal quantities in the heterozygous state.In the homozygous state all or nearly all the haemoglobin present is of the abnormal type, the patient showing the features of the appropriate disease.In patients with haemoglobin-H disease the proportion of abnormal haemoglobin found varies from about 10 to 35%.It is irregularly found in relatives of these patients.In both these respects it resembles the appearance of haemo- globin-F in thalassaemia.Clinically, haemoglobin-H disease is very similar to thalassaemia minor.Two cases of this rare disease are reported in which red-cell survival and marrow iron turnover have been studied.
Comparative toxicity of gold preparations in treatment of rheumatoid arthritis.
Authors: J S Lawrence
Journal: Annals of the Rheumatic Diseases (1976)

Patients with rheumatoid arthritis have been treated alternately with aurothioglucose and aurothiomalate. In the earlier part of the study an oily suspension of aurothioglucose and an aqueous solution of aurothiomalate were used, but later an aqueous solution of aurothioglucose was alternated with the oily suspension and an oily suspension of aurothiomalate with the aqueous solution. Skin eruptions, stomatitis, and albuminuria were significantly more common in patients treated with the aqueous solution than with the oily suspension.
Fibrosis progression in chronic hepatitis C: Morphometric image analysis in the HALT-C trial
Authors: Zachary D. Goodman, Anne M. Stoddard, Herbert L. Bonkovsky, Robert J. Fontana, Marc G. Ghany, Timothy R. Morgan, Elizabeth C. Wright, Elizabeth M. Brunt, David E. Kleiner, Mitchell L. Shiffman, Gregory T. Everson, Karen L. Lindsay, Jules L. Dienstag, Chihiro Morishima
Journal: Hepatology (2009)

Computer-assisted morphometry can provide precise measurement of hepatic fibrosis on a continuous scale. Previous morphometric studies of large cohorts of patients with treatment refractory chronic hepatitis C have shown a mean increase in fibrosis of 30% to 58% in 1 year. The aim of the present study was to quantify fibrosis progression in biopsy specimens obtained over 1.5 to 5 years from three groups of patients with baseline bridging fibrosis or cirrhosis (Ishak stages 3-6) enrolled in the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis Trial. The main group of 346 lead-in nonresponders (viremic after 24 weeks of peginterferon-ribavirin therapy) had a mean fibrosis increase of 61% over pretreatment baseline after 2 years and 80% after 4 years. In contrast, the 78 breakthrough/relapse patients (undetectable serum hepatitis C virus RNA after 24 weeks of peginterferon-ribavirin and receiving antiviral therapy for 48 weeks) showed a mean increase in fibrosis of 48% when biopsied 36 months from pretreatment baseline but no further increase at 60 months. Finally, the 111 express patients with baseline biopsies following unsuccessful peginterferon-ribavirin outside the trial had significantly more baseline fibrosis than the others but an increase of only 21% after 21 months and a slight decrease at 45 months. Maintenance therapy with low-dose peginterferon had no effect on fibrosis changes in any of the groups. Conclusion: Morphometry demonstrated complex, nonlinear changes in fibrosis over time in this heterogeneous cohort of patients with interferon-refractory chronic hepatitis C. (HEPATOLOGY 2009.)
Psychology of the allergic patient
Authors: F‐B. Michel
Journal: Allergy (1994)

Biological hypersensitivity is the fundamental feature of atopy, and patients suffering from this syndrome are characterized by their ability to produce high levels of IgE in response to low amounts of antigen. This hypersensitivity results in a range of acute and chronic diseases, such as asthma, rhinitis, allergic conjunctivitis and atopic dermatitis. In addition to their biological effects, these diseases may have psychological consequences in terms of stress, anxiety or depression. However, atopic patients, far from displaying a typical depressive psychological profile, are characterized by their increased emotional sensitivity. Atopic individuals alert us to the presence of allergens but perhaps they also indicate something about our way of life. Are the symptoms displayed by allergic patients, their wheezing, sneezing or itching skin, more than a simple biological response?
Book: The Practice of Reform in Health, Medicine and Science, 1500-2000
Authors: David Hughes
Journal: BMJ (2006)

Healthcare reform has become a global phenomenon. Countries around the world are reshaping their health systems. The modified systems are often based on Western models and are subject to terms of “conditionality” imposed by supranational funding bodies. Many European countries seem to be locked into a continuous cycle of reform akin to Maostyle permanent revolution. Reform has become routine, and “reform fatigue” is widespread.​widespread.




Figure 1



Eds Margaret Pelling, Scott Mandelbrote

Ashgate, £55, pp 376 ISBN 0 7546 3933 9

Rating: ★★⋆⋆




A major health policy conference to be held in Israel later this year is entitled “Are we in a post-reform era?” Its thesis is that reform ideas have been recycled to the point that genuinely new approaches are scarce or non-existent. Some people will find this thesis too radical. A more commonsense view is that reform always has occurred and always will occur, and that questions about the merit of reform reflect the uncertainty of those periods where progress slows to the point that little seems to change. However, such debates raise intriguing questions about our current understanding of reform and the provenance of the concept and whether reform is an essentially modern idea.

A volume on the history of reform might be expected to shed light on these contemporary issues. Although the reader has to do a little digging, Pelling and Mandelbrote's edited collection, written in honour of the social historian Charles Webster, provides some answers. The first chapter describes the profound shift in theological thinking that occurred as Renaissance notions about the improvement of man in God's image opened a space for innovation and progress. Later chapters dissect the thesis that Protestantism and the social changes it brought opened the way for developments in the new astronomy, physics, and mathematics.

This book shows us that the domains of reform can change over time in subtle ways, as with the shifting conceptualisation of resource allocation in the NHS, but also that seemingly new policy developments often have continuities with the past, as with recruitment of nurses overseas. Doctors have often been largely “detached” from the political and social processes that supported reform, but at critical junctures they have moved centre stage to shape the nature of learned societies and of the settlement between the professions and the state.

My main disappointment with this book is that the “practice of reform” often remains in the background. The authors shy away from analysis of the concept of reform itself, so that “reform” is often used synonymously with innovation, new conjunctions of ideas, scientific development, and incremental policy change. However, reform as we understand it today is about rapid transformational change that is based on rational planning and modern conceptions of governance. Perhaps the lesson is that we did not get to this position all at once and need to further examine the steps we took along the way.
An Educational Model
Authors: Charles D. Aring
Journal: JAMA (1972)

"We must educate people in what nobody knew yesterday, and prepare people in our schools for what no one knows yet, but what some people must know tomorrow," says Margaret Mead. This has been the goal of medical education for as long as I can remember. Having opted for a lifetime of learning and there being no question about his intelligence, the student of medicine is encouraged to take the initiative and practice what he hears and sees. Doing as well as studying under supervision, while no royal road to learning, is as good as has been devised to date. By broadening the sources of responsibility, all the while encouraging dissent, the student is afforded the moral advantage of becoming excellent in his own way. "... it is impossible you should take true root but by the fair weather that you make yourself: it is needful that you frame the season
Which is the best surgery for budd-chiari syndrome: Venous decompression or liver transplantation? a single-center experience with 50 patients
Authors: Burckhardt Ringe, Hauke Lang, Karl-Jürgen Oldhafer, Michael Gebel, Peer Flemming, Axel Georgii, Hans-Georg Borst, Rudolf Pichlmayr
Journal: Hepatology (1995)

The optimal treatment of Budd-Chiari syndrome (BCS) remains an open question. It is still a matter of controversial discussion whether venous decompression or liver transplantation is superior. To elucidate the role and prognosis of both surgical options in our own experience, a consecutive series of 50 patients treated between 1981 and 1993 was retrospectively analyzed. Twelve patients had different types of portosystemic shunts or local decompressive procedures, and transplantation was performed in 43 cases, including five with previous conventional surgery. The overall mortality of 18 of 50 was conventional surgery. The overall mortality of 18 of 50 was concentrated within the early postoperative period, with no patient lost after 1 year. In the venous decompression group, the success rate was only 29%, and treatment failure was closely related to the finding of cirrhosis or technical problems like vascular thrombosis. After transplantation, early complications were rejection, primary nonfunction, or graft necrosis, and contributed significantly to the risk of sepsis. Thirty of 43 liver recipients are currently alive, including four rescued after failed decompressive surgery, with 1- and 10-year survival of 69%, and excellent recurrence-free rehabilitation. These results clearly indicate that patient selection plays a dominant prognostic role in the treatment of BCS. Venous decompression and liver transplantation should both be integrated in a common therapeutic concept, and the individual decision for the preferred approach must be based on the leading clinical symptom: portal hypertension or liver failure, together with the assessment of reversibility of hepatic damage, and the potential of cure of the underlying disease.
Exercise Lowers Type 2 Diabetes Risk After Gestational Diabetes
Authors: Anita Slomski
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Follow-up of recurrent hepatitis B and delta infection in liver allograft recipients after treatment with recombinant interferon-α
Authors: U. Hopf, P. Neuhaus, H. Lobeck, V. König, S. Küther, J. Bauditz, W.-O. Bechstein, G. Blumhardt, R. Steffen, R. Neuhaus, D. Huhn
Journal: Journal of Hepatology (1991)
Hospitalization for Mental Illness among Parents after the Death of a Child
Authors: Jiong Li, Thomas Munk Laursen, Dorthe Hansen Precht, Jørn Olsen, Preben Bo Mortensen
Journal: New England Journal of Medicine (2005)

The loss of a child is considered one of the most stressful events in the life of a parent. We hypothesized that parental bereavement increases the risk of hospital admission for a psychiatric disorder, especially for affective disorders.
Chronic Dizziness among Older Adults
Authors: Michael I. Weintraub
Journal: Annals of Internal Medicine (2000)

Letters20 June 2000Chronic Dizziness among Older AdultsMichael I. Weintraub, MDMichael I. Weintraub, MDNew York Medical College; Briarcliff, NY 10510 (Weintraub)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I applaud Tinetti and coworkers' comprehensive approach to the study of dizziness in the geriatric population (1). However, the notion that dizziness is purely a geriatric disease is misguided and may delay a physician's approach to proper diagnosis and treatment. Many factors are relevant, but the authors did not mention a common causation.In 1992 and 1993, I described the “beauty parlor stroke syndrome” in elderly women, with subsequent demonstration of vertebral artery flow reduction at the atlanto-occipital and atlanto-axial junction by hyperextension and rotation movements (2). Distinct hemodynamic changes of slow flow, reversal of flow, and ...References1. Tinetti ME, Williams CS, Gill TN. Dizziness among older adults: a possible geriatric syndrome. Ann Intern Med. 2000;132:337-44. LinkGoogle Scholar2. Weintraub M. Beauty parlor stroke syndrome: report of five cases. JAMA. 1993;269:2085-6. CrossrefMedlineGoogle Scholar3. Weintraub MI, Khoury A. Cerebral hemodynamic changes induced by simulated tracheal intubation: a possible role in perioperative stroke? Magnetic resonance angiography and flow analysis in 160 cases. Stroke. 1998;29:1644-9. CrossrefMedlineGoogle Scholar4. Shimura H, Yuzawa K, Nozuc M. Stroke after visit to the hairdresser. Lancet. 1997;350:1777-8. CrossrefGoogle Scholar5. Drachman DA. Occam's razor, geriatric syndromes, and the dizzy patient [Editorial]. Ann Intern Med. 2000;132:403-5. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: New York Medical College; Briarcliff, NY 10510 (Weintraub) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDizziness among Older Adults: A Possible Geriatric Syndrome Mary E. Tinetti , Christianna S. Williams , and Thomas M. Gill Occam's Razor, Geriatric Syndromes, and the Dizzy Patient David A. Drachman Some Considerations regarding Geriatric Syndromes Elizabeth A. Phelan , Elizabeth K. Vig , and Itamar B. Abrass Metrics Cited bySome Considerations regarding Geriatric SyndromesElizabeth A. Phelan, MD, MS, Elizabeth K. Vig, MD, MPH, and Itamar B. Abrass, MD 20 June 2000Volume 132, Issue 12Page: 1009-1010KeywordsArteriesBiomarkersElderlyGeriatricsHemodynamicsInfarctionMagnetic resonance imagingStroke Issue Published: 20 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Multiple Roles for the Major Histocompatibility Complex Class I– Related Receptor FcRn
Authors: Victor Ghetie, E. Sally Ward
Journal: Annual Review of Immunology (2000)

Multiple functions have recently been identified for the neonatal Fc receptor FcRn. In addition, a human homolog of the rodent forms of FcRn has been identified and characterized. This major histocompatibility complex class I-related receptor plays a role in the passive delivery of immunoglobulin (Ig)Gs from mother to young and the regulation of serum IgG levels. In addition, FcRn expression in tissues such as liver, mammary gland, and adult intestine suggests that it may modulate IgG transport at these sites. These diverse functions are apparently brought about by the ability of FcRn to bind IgGs and transport them within and across cells. However, the molecular details as to how FcRn traffics within cells have yet to be fully understood, although in vitro systems have been developed for this purpose. The molecular nature of the FcRn-IgG interaction has been studied extensively and encompasses residues located at the CH2-CH3 domain interface of the Fc region of IgG. These Fc amino acids are highly conserved in rodents and man and interact with residues primarily located on the α2 domain of FcRn. Thus, it is now possible to engineer IgGs with altered affinities for FcRn, and this has relevance to the modulation of IgG serum half-life and maternofetal IgG transport for therapeutic applications.
Editorial
Authors: FELIX E. MOORE, OGLESBY PAUL, GEORGE E. WAKERLIN
Journal: Circulation (1964)

THE article, "Comparability of Criteriaand Methods in the Epidemiology of Cardiovascular Disease," which appears in this issue, is another indication of the coming of age of this important, but relatively new, approach to the study of cardiovascular disease.It also points up the need for discussion of re- search strategy and tactics in this rapidly growing field of research.The authors, Drs.Weinstein and Epstein, are, respectively, the staff physician and the chairman of the American Heart Association's Subcommittee on Criteria and Methods of the Committee * on Epidemiological Studies.Formed as a result of the report of the Prince- ton Conference,1 the subcommittee, composed of physicians and biostatisticians active in the field, developed plans for a survey of criteria and methods used in the various epidemiologic studies in this country.The subcommittee surveyed no less than 57 studies ranging from broadly based com- munity studies, through studies concentrating on occupational, ethnic and religious groups, and ending, appropriately, with studies based on autopsy findings or death certificates.The 52 studies on living populations have covered no less than 363,000 persons.The five mor- tality investigations included in this survey, which do not however encompass all studies using vital statistics, were based on over 20,-* Now the Council on Epidemiology of the Associa- tion.