tbuckley/cabot-search huggingface dataset:
ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function
Authors: Takayuki Shindo, Hiroki Kurihara, Kouji Kuno, Hitoshi Yokoyama, Takashi Wada, Yukiko Kurihara, Tomihiko Imai, Yuhui Wang, Masafumi Ogata, Hiroaki Nishimatsu, Nobuo Moriyama, Yoshio Oh-hashi, Hiroyuki Morita, Takatoshi Ishikawa, Ryozo Nagai, Yoshio Yazaki, Kouji Matsushima
Journal: Journal of Clinical Investigation (2000)

A disintegrin and metalloproteinase (ADAM) represents a protein family possessing both metalloproteinase and disintegrin domains. ADAMTS-1, an ADAM family member cloned from cachexigenic colon adenocarcinoma, is unusual in that it contains thrombospondin type I motifs and anchors to the extracellular matrix. To elucidate the biological role of ADAMTS-1, we developed ADAMTS-1-null mice by gene targeting. Targeted disruption of the mouse ADAMTS-1 gene resulted in growth retardation with adipose tissue malformation. Impaired female fertilization accompanied by histological changes in the uterus and ovaries also resulted. Furthermore, ADAMTS-1(-/-) mice demonstrated enlarged renal calices with fibrotic changes from the ureteropelvic junction through the ureter, and abnormal adrenal medullary architecture without capillary formation. ADAMTS-1 thus appears necessary for normal growth, fertility, and organ morphology and function. Moreover, the resemblance of the renal phenotype to human ureteropelvic junction obstruction may provide a clue to the pathogenesis of this common congenital disease.
Lack of clinically relevant differences between combination therapy and monotherapy in COPD
Authors: Brian J. Lipworth
Journal: European Respiratory Journal (2014)

Lack of clinically relevant differences between combination therapy and monotherapy in COPDTo the Editor: BATEMAN et al. [1] reported significantly greater mean improvements with indacaterol/glycopyrronium combination therapy, Ultibro Breezhaler (QVA149) compared to monotherapy with either indacaterol (0.07 L), glycopyrronium (0.09 L) or tiotropium (0.08 L) for the primary outcome of trough forced expiratory volume in 1 s (FEV1) at week 26 in patients with chronic obstructive pulmonary disease (COPD).However, such improvements were all less than the 0.1-0.14L range that represents the minimal clinically important difference (MCID) for FEV1 [2].Pointedly, the mean differences between combination therapy and monotherapy for the secondary outcomes of dyspnoea (transition dyspnoea index score) and health status (St.George's Respiratory Questionnaire score) were also less than the respective MCID values, with a significant difference between Ultibro Breezhaler (QVA149) and tiotropium at week 26.Analysis of individual responders revealed a significantly higher proportion of patients exceeding the MCID for transition dyspnoea index (o1 unit) and St. George's Respiratory Questionnaire (o4 units) with QVA149 versus tiotropium but not indacaterol or glycopyrronium.These data do not therefore support the conclusion that QVA149 demonstrated clinically relevant superiority versus their respective monotherapy components in COPD.Clinically relevant differences not found between combination and monotherapy http://ow.ly/thbE4
Transparent Skin and Osteoporosis : A Study in Patients with Rheumatoid Disease
Authors: B. McConkey, G. M. Fraser, A. S. Bligh
Journal: Annals of the Rheumatic Diseases (1965)

We have described elsewhere (McConkey, Fraser, Bligh, and Whiteley, 1963) an abnormality of the skin which we called transparent skin.In a number of patients, none of whom had rheumatoid disease, we found an association between transparent skin and osteoporosis.We suggested that both the transparency of the skin and the osteoporosis were the consequences of a disorder of connective tissue.We now report a study of transparent skin and osteoporosis in patients suffering from a known disorder of connective tissue, rheumatoid disease.
HERETOFORE UNDESCRIBED AEROBIC SPORE FORMING BACILLUS IN CHILD WITH MENINGITIS
Authors: Dan P. Boyette
Journal: JAMA (1952)

The encountering of a new organism, which, on competent bacteriological study, is found to be one never before described and not known to be naturally pathogenic, is an experience we feel should be recorded. We believe the following case report will interest both the clinician and the bacteriologist. <h3>REPORT OF A CASE</h3> On Dec. 5, 1948, a 5-day-old Negro boy was examined because of convulsions. He had been delivered at home by a midwife after a full-term, uncomplicated pregnancy. Neonatal course was uneventful until the night before the day of admission, when the first convulsion occurred. He was breast fed, and the mother showed no signs of illness. Family history was noncontributory. There were no concomitant or recent illnesses among the siblings or the parents. When the infant was first seen by us, physical examination showed negative results. The cord was sloughing from the umbilicus and the temperature was normal.
Norepinephrine reverses the effects of activin A on DNA synthesis and apoptosis in cultured rat hepatocytes
Authors: Y Zhang, M Kanzaki, H Mashima, T Mine, I Kojima
Journal: Hepatology (1996)

Activin A, an autocrine factor produced by hepatocytes, inhibits mitogen-stimulated DNA synthesis and induces apoptotic death of cultured rat hepatocytes. Several lines of evidence indicate that norepinephrine (NE), as a comitogenic growth factor, alters the balance between growth stimulation and inhibition and acts as a trigger for the initiation of hepatocyte proliferation. In the present study, we examined whether NE modulated the effects of activin A on rat hepatocytes in primary culture. Activin A, at a concentration of 10 −9 mol/L, blocked the effect of epidermal growth factor (EGF) on DNA synthesis, that was assessed by measuring [ 3 H] thymidine incorporation and nuclear labeling, almost completely, and NE reversed the inhibitory effect of activin A on DNA synthesis. This effect of NE was dose- dependent, being significant at concentrations of 10 −6 mol/L and above, but was overcome by higher concentrations of activin A, and was attenuated by prazosin, but not by yohimbine or propranolol. NE exerted its effect during the first 24 hours of culture, but was ineffective when added after 24 hours. EGF augmented the release of follistatin, an activin-binding protein known to block the action of activin A, by hepatocytes and NE did not affect the amount of follistatin they released. In addition to inhibiting DNA synthesis by hepatocytes cultured with EGF, activin A induced death of hepatocytes cultured in the absence of EGF. The nuclear morphology of cells cultured with activin A alone was strikingly changed compared with untreated control cells and marked identation of the nuclear membranes and moderate chromatin condensation were observed. Fragmentation of DNA was also observed, suggesting that activin A induced apoptosis, and activin-mediated cell death was prevented significantly by NE. These results indicate that NE, acting on α 1 -adrenergic receptors, attenuates the effects of activin A on DNA synthesis by and apoptosis of cultured rat hepatocytes.
Myxoma of the Left Atrium Simulating Mitral Stenosis
Authors: JOHN W. HARRISON, LAWRENCE J. MCCORMACK, A. CARLTON ERNSTENE
Journal: Circulation (1954)

A case of myxoma of the left atrium originally diagnosed as mitral stenosis has been presented. Analysis of the clinical and roentgenologic features and the data obtained from cardiac catheterization indicate that a correct diagnosis probably could have been made. Certain of the findings suggest that although prolapse of the tumor into the orifice of the mitral valve was responsible for striking changes in the patient's condition, the site of the chronic obstruction responsible for the pulmonary hypertension and the changes in the pulmonary arterioles may have been at the atrial orifices of the pulmonary veins.
Using the micronucleus assay to detect genotoxic effects of metal ions.
Authors: J Bérces, M Otos, S Szirmai, C Crane-Uruena, G J Köteles
Journal: Environmental Health Perspectives (1993)

The lymphocyte micronucleus assay was used to measure the average frequency of micronuclei in a population and thus assess genotoxic effects. Data from 174 persons give an average value of 16.4 +/- 7.3, and a slight age-dependence was observed. To detect combined environmental mutagen injuries the micronucleus assay was used to study the effects of metal compounds. Cadmium ions increased the micronucleus frequency linearly after incubation with whole blood in vitro with 10(6)-10(-3) M concentrations for 30 min. Similarly, a linear increase in micronucleus frequency was detected with 10(-3)-10(-1) M mercury ions. Concerning the biological effect of selenium, it was found that neither sodium selenite nor selenium dioxide induced increases at concentrations of 10(-7)-10(-6) M; 10(-5) M caused a slight increase; 10(-4) M, however, destroyed the cells. These results suggest that the human lymphocyte micronucleus test can be used to assess genotoxic injuries due to environmental effects in human lymphocytes.
Chemotherapy of Gonorrhoea
Authors: R. Marinkovitch
Journal: BMJ (1939)

METCLE BRTSH 317 us in recalling her memory, as of eighteenth-century pot- pourri, also more vividly recall what we owe each of us to his own wife.There should be a special petition in the Litany for the women whose domestic routine is daily at the mercy of the acute appendix and the perforated gastric ulcer.
Comparison of Adrenergic Beta-receptor Antagonists in Angina Pectoris
Authors: U. Thadani, B. Sharma, M. K. Meeran, P. A. Majid, W. Whitaker, S. H. Taylor
Journal: BMJ (1973)

The symptomatic, electrocardiographic, and circulatory effects of intravenous and oral preparations of propranolol, oxprenolol, and practolol were compared in 16 patients with uncomplicated angina pectoris precipitated by exertion. The method of study included treadmill exercise, double-blind assessment, single-blind analysis, with placebo control and randomized serial comparison of each drug in each patient. The doses used were selected to give the same near-maximum suppression of the heart rate response to exercise. The symptomatic, electrocardiographic, and circulatory response of each patient to both preparations of each of the three drugs was similar. Exercise tolerance was increased in two-thirds, unchanged in one-sixth, and significantly worsened in one-sixth of the studies. Electrocardiographic evidence of myocardial ischaemia was conspicuously reduced by all three drugs in most studies irrespective of their symptomatic effects. Though the exclusive choice of patients, the single dose design of the trial, and the treadmill method of assessment limit the general application of these results, they do clearly indicate that in doses that induce equal suppression of the exercise heart rate these three drugs have similar distinct anti-anginal activity. Their ancillary pharmacological properties are probably of little importance in this respect. Equally, the similarity in the symptomatic, circulatory, and electrocardiographic response to the intravenous and oral preparations suggests that metabolic breakdown products are probably of therapeutic importance only in so far as they antagonize beta-receptor activity.
INFLUENZA COMMENCING WITH SUDDEN UNCONSCIOUSNESS, AND EXCESSIVE DYSPNOEA
Authors: W. Harris
Journal: BMJ (1907)

We describe a case report of a man aged 56 years with a 4-month history of right-sided sciatica-type pain with subclinical disc prolapse evident on MRI. Worsening pain together with the appearance of a tender mass in his right buttock prompted further imaging, which demonstrated an infiltrative mass engulfing the lumbosacral plexus. This was later shown to be a granulocytic sarcoma on biopsy. Intervertebral disc herniation can be an incidental finding and is not always the cause of sciatica.
MYOCARDIAL EXPRESSION OF THE MICRORNA DRE-MIR-133A-5P IS ASSOCIATED WITH IMPROVEMENT IN LEFT VENTRICULAR EJECTION FRACTION IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY TREATED WITH BETA-BLOCKERS
Authors: Michael Albert Hinterberg, David Kao, Anis Karimpour-Fard, Kika Sucharov, Lawrence E. Hunter, David Port, Michael Bristow
Journal: Journal of the American College of Cardiology (2013)
Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine
Authors: Harshad P Patil, Senthil Murugappan, Wouter ter Veer, Tjarko Meijerhof, Aalzen de Haan, Henderik W Frijlink, Jan Wilschut, Wouter L J Hinrichs, Anke Huckriede
Journal: Journal of Controlled Release (2013)
Hunt denies that the government's "reforms" lessen his responsibility for the NHS
Authors: G. Iacobucci
Journal: BMJ (2012)

The health secretary, Jeremy Hunt, has insisted that he would not abdicate his responsibility for delivering care in the NHS when he devolves power to local doctors to commission £60bn (€74bn; $96bn) of healthcare services in England. He acknowledged that his head would be “on the block” if the government’s changes to the NHS failed to deliver.

In a keynote speech to delegates …
Periodic Limb Movements in Sleep — Endophenotype for Restless Legs Syndrome?
Authors: John W. Winkelman
Journal: New England Journal of Medicine (2007)

Today, 350 years after its first description, the restless legs syndrome (RLS) is strangely controversial. Experts and patients alike describe RLS both as a miserably impairing disorder and as "the most common disorder you have never heard of." Critics do not regard RLS as a disorder at all but, rather, as the fabrication of an omnivorous pharmaceutical industry. RLS is a waking sensorimotor disturbance with features of both neurologic and sleep disorders. Those afflicted describe an intensely uncomfortable, overwhelming urge to move the legs (often accompanied by dysesthesias), predominantly in the evening or at night, that is present at rest . . .
Obstructive Sleep Apnea and Stroke
Authors: Pankaj Madan
Journal: Annals of Internal Medicine (2005)

Letters6 September 2005Obstructive Sleep Apnea and StrokePankaj Madan, MDPankaj Madan, MDFrom University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-5-200509060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The review on obstructive sleep apnea by Caples and colleagues (1) made for interesting reading, but the authors overlooked the association between obstructive sleep apnea and cerebrovascular disease. The most difficult challenge in understanding the link between hypertension and cardiovascular and cerebrovascular disease is the presence of significant obesity in most adult patients with obstructive sleep apnea. Obesity tends to be differentially distributed in the abdomen and upper body, probably producing much of its effect on sleep apnea through the deposition of fat in the neck, narrowing the pharyngeal airway. Whether this fat distribution pattern rather than ...References1. Caples SM, Gami AS, Somers VK. Obstructive sleep apnea. Ann Intern Med. 2005;142:187-97. [PMID: 15684207] LinkGoogle Scholar2. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Javier Nieto F, et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med. 2001;163:19-25. [PMID: 11208620] CrossrefMedlineGoogle Scholar3. Bassetti C, Aldrich MS. Sleep apnea in acute cerebrovascular diseases: final report on 128 patients. Sleep. 1999;22:217-23. [PMID: 10201066] CrossrefMedlineGoogle Scholar4. Yaggi K, Kernan W, Mohsenin V. The association between obstructive sleep apnea and stroke [Abstract]. Am J Respir Crit Care Med. 2003;167:A173. Google Scholar Author, Article, and Disclosure InformationAuthors: Pankaj Madan, MDAffiliations: From University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoObstructive Sleep Apnea Sean M. Caples , Apoor S. Gami , and Virend K. Somers Obstructive Sleep Apnea and Stroke Sean M. Caples and Virend K. Somers Metrics 6 September 2005Volume 143, Issue 5Page: 390KeywordsCerebrovascular diseasesFatsHypertensionIschemic strokeLongitudinal studiesMedical risk factorsObesitySleep apneaStrokeTransient ischemic attacks ePublished: 6 September 2005 Issue Published: 6 September 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Positive regulation of hepatic miR-122 expression by HNF4α
Authors: Zhen-Ya Li, Yang Xi, Wen-Nan Zhu, Chao Zeng, Zhu-Qin Zhang, Zhi-Chen Guo, De-Long Hao, Guang Liu, Lei Feng, Hou-Zao Chen, Feng Chen, Xiang Lv, De-Pei Liu, Chih-Chuan Liang
Journal: Journal of Hepatology (2011)
Pleural Mesothelioma in New Caledonia: Associations with Environmental Risk Factors
Authors: Francine Baumann, Pierre Maurizot, Morgan Mangeas, Jean-Paul Ambrosi, Jeroen Douwes, Bernard Robineau
Journal: Environmental Health Perspectives (2010)

High incidences of malignant mesothelioma (MM) have been observed in New Caledonia. Previous work has shown an association between MM and soil containing serpentinite.We studied the spatial and temporal variation of MM and its association with environmental factors.We investigated the 109 MM cases recorded in the Cancer Registry of New Caledonia between 1984 and 2008 and performed spatial, temporal, and space-time cluster analyses. We conducted an ecological analysis involving 100 tribes over a large area including those with the highest incidence rates. Associations with environmental factors were assessed using logistic and Poisson regression analyses.The highest incidence was observed in the Houaïlou area with a world age-standardized rate of 128.7 per 100,000 person-years [95% confidence interval (CI), 70.41-137.84]. A significant spatial cluster grouped 18 tribes (31 observed cases vs. 8 expected cases; p = 0.001), but no significant temporal clusters were identified. The ecological analyses identified serpentinite on roads as the greatest environmental risk factor (odds ratio = 495.0; 95% CI, 46.2-4679.7; multivariate incidence rate ratio = 13.0; 95% CI, 10.2-16.6). The risk increased with serpentinite surface, proximity to serpentinite quarries and distance to the peridotite massif. The association with serpentines was stronger than with amphiboles. Living on a slope and close to dense vegetation appeared protective. The use of whitewash, previously suggested to be a risk factor, was not associated with MM incidence.Presence of serpentinite on roads is a major environmental risk factor for mesothelioma in New Caledonia.
P1324 LEDIPASVIR (LDV) AND SOFOSBUVIR (SOF) COMBINATION IMPROVES PATIENT-REPORTED OUTCOMES (PRO) DURING TREATMENT OF CHRONIC HEPATITIS C (CH-C) PATIENTS: RESULTS FROM THE ION-1 CLINICAL TRIAL
Authors: Z. Younossi, M. Stepanova, P. Marcellin, N. Afdhal, F. Nader, S. Hunt
Journal: Journal of Hepatology (2014)
Endoscopic sphincteroplasty: a novel and safe alternative to papillotomy in the management of bile duct stones.
Authors: P Mac Mathuna, P White, E Clarke, J Lennon, J Crowe
Journal: Gut (1994)

Removal of bile duct stones during endoscopic retrograde cholangiopancreatography (ERCP) usually includes papillotomy. Papillotomy is associated with occasional complications and in addition, the longterm sequelae of papillotomy in young patients having laparoscopic cholecystectomy remain unclear. As an alternative to papillotomy, this study prospectively evaluated the efficacy and safety of endoscopic balloon sphincteroplasty to facilitate bile duct clearance. Of 32 patients with bile duct stones (diameter 3-30 mm) at ERCP, sphincteroplasty was considered inappropriate in four patients because of stone size (&gt; 20 mm) necessitating papillotomy for bile duct clearance. Sphincteroplasty was performed in the remaining 28 patients to permit duct clearance by dormier basket, balloon or mechanical lithotripsy. The bile duct was cleared in 22 patients (79%) while additional measures including papillotomy or stent insertion were required in the remaining six patients (21%) because of stone size or technical difficulties. There was no associated papillary haemorrhage. Pancreatitis was seen in one patient (4%) but resolved within 24 hours. Our preliminary experience suggests that sphincteroplasty is a safe and effective sphincter preservation technique that significantly reduces the necessity for papillotomy in the management of bile duct stones.
Well-defined cross-linked antioxidant nanozymes for treatment of ischemic brain injury
Authors: Devika S. Manickam, Anna M. Brynskikh, Jennifer L. Kopanic, Paul L. Sorgen, Natalia L. Klyachko, Elena V. Batrakova, Tatiana K. Bronich, Alexander V. Kabanov
Journal: Journal of Controlled Release (2012)
Cigarette possession becomes illegal for Novia Scotia's under 19s
Authors: D. Spurgeon
Journal: BMJ (2003)

On 1 January it became illegal for people under the age of 19 in the Canadian province of Nova Scotia to possess or smoke cigarettes. Young people caught with cigarettes by police will not be charged or fined, but police will be authorised to confiscate the cigarettes.

The province's Act to Protect Young Persons and Other Persons from Tobacco Smoke is one of Canada's most extensive tobacco laws. British Columbia, Newfoundland, and Labrador have also enacted antismoking regulations.

Nova Scotia's new act is controversial, with …
Marriage, Family, and Parenthood
Authors: HENRY GREENBAUM
Journal: American Journal of Psychiatry (1973)

The author discusses the recent attacks against marriage, family, and parenthood by some of the leaders of the Women's Liberation Movement. He points out that the difficulties that cause human suffering in these institutions are not intrinsic to them but are determined by the quality of the people involved in them. He believes there is a deep human need for marriage, family, and parenthood, which has its roots in the prolonged biological and psychological dependency of the human child. The conditions of personality development necessary for successful functioning in marriage, family, and parenthood are analyzed.
Young adult Americans set to gain expanded access to health insurance
Authors: B. Roehr
Journal: BMJ (2010)

An estimated 13.7 million uninsured young adult Americans (ages 19 to 26) might gain access to health insurance under recently passed health reform legislation, according to a new report from the charity The Commonwealth Fund. They account for about a third of all people without health insurance in the US.

The first to benefit will be an estimated 1.2 million young adults who will become eligible for coverage under their parent’s family policy that is either directly purchased or provided through their employer. The provision is due to come into effect in September 2010 but 65 major insurance companies have announced that they will implement …
Tribunals should replace fitness to practise panels, GMC proposes
Authors: C. Dyer
Journal: BMJ (2011)

UK doctors facing serious concerns about their practice would in future go before a medical practitioners tribunal, possibly chaired by a lawyer, under proposals from the General Medical Council for major changes to enhance the independence of its disciplinary role.

The tribunals, which would replace the current fitness to practise panels, would remain part of the GMC but would be in a separate service overseen by an independent statutory committee. The tribunal service would be led by a separate chair with “significant judicial experience” who would report to parliament every year.

Either all tribunal hearings or else just the most complex hearings would have a legally …