tbuckley/cabot-search huggingface dataset:
Insulin regulates the paracellular permeability of cultured intestinal epithelial cell monolayers.
Authors: J A McRoberts, R Aranda, N Riley, H Kang
Journal: Journal of Clinical Investigation (1990)

The T84 human colonic epithelial cell line retains the ability to produce secretagogue-responsive monolayer cultures with high transepithelial resistance when grown and maintained on collagen-coated permeable supports in media supplemented with 5% newborn calf serum. The addition of highly purified insulin to the basolateral but not the apical membrane side of established monolayers caused the transepithelial resistance to decline more than eightfold over a 3-4-d period. By comparing the transepithelial flux of 22Na with that of the extracellular space marker, [3H]mannitol, the decline in electrical resistance was shown to be due solely to an effect on tight junction-mediated paracellular permeability. The effect of insulin was dose dependent with a half-maximal effect at 3.9 ng/ml (approximately 0.7 nM) and fully reversible over a 10-d time course. Simultaneous addition of 2 microM cycloheximide prevented the insulin-induced decline in resistance; in fact, this combination caused a significant increase in electrical resistance. There was no effect on the short-circuit current response of insulin-treated monolayers to secretagogues so long as media was changed daily. While no gross morphological changes were apparent, there did appear to be a subtle condensation of the perijunctional actin ring as visualized using rhodamine-labeled phalloidin. These results demonstrate that insulin modulates the permeability of the occluding junction in T84 cell monolayers through a receptor mediated process which probably involves changes in protein synthesis and cytoskeletal structure. Insulin was also shown to produce similar effects on two other intestinal epithelial cell lines.
Pneumoconiosis-related Lung Cancers
Authors: MOTOO KATABAMI, HIROTOSHI DOSAKA-AKITA, KOICHI HONMA, YOSHIAKI SAITOH, KIYONOBU KIMURA, YOSHIKAZU UCHIDA, HIROSHI MIKAMI, YUTAKA OHSAKI, YOSHIKAZU KAWAKAMI, KOKICHI KIKUCHI
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

It has been reported that patients with pneumoconiosis occasionally have a diffuse interstitial fibrosis (DIF) that resembles interstitial pneumonia, but little is known about the relation between pneumoconiosis-associated DIF and the risk of lung cancer. In the present study, we evaluated the incidence of DIF by chest CT and its contribution to lung cancer in 563 patients with nonasbestos pneumoconiosis. Fifty-five (10%) of the 563 patients had DIF. Pneumoconiosis with DIF had an exceedingly high concurrence of lung cancers when compared with pneumoconiosis without DIF (29 [53%] of 55 versus 78 [15%] of 508, p < 0.001). Squamous cell carcinomas (SCCs) of the lung from pneumoconiosis with DIF exclusively comprised peripheral-types, as compared with SCCs from pneumoconiosis without DIF (13 [100%] of 13 versus 33 [72%] of 46, p = 0.03). In addition, lung cancers arose frequently from the area of DIF in pneumoconiosis with DIF (20 [74%] of 27). Furthermore, our pathologic examination revealed that dysplasias from pneumoconiosis with DIF were significantly more frequently observed in peripheral bronchioli than were dysplasias from pneumoconiosis without DIF (11 [69%] of 16 versus 20 [30%] of 66, p = 0.01). p53 expression evaluated by immunohistochemistry was frequently observed in dysplasias from pneumoconiosis with DIF, although it was not significantly different compared with that in dysplasias from pneumoconiosis without DIF (5 [50%] of 10 versus 12 [38%] of 32). Taken together, these results may suggest a positive causal relationship between pneumoconiosis and peripheral-type SCCs of the lung, and further indicate a pivotal role of diffuse fibrosis for the excess incidence of lung cancers, especially peripheral-type SCCs, in DIF-type pneumoconiosis.
Gene transfer of truncated IκBα prevents tubulointerstitial injury
Authors: Osamu Takase, Junichi Hirahashi, Atsushi Takayanagi, Akihiro Chikaraishi, Takeshi Marumo, Yuri Ozawa, Matsuhiko Hayashi, Nobuyoshi Shimizu, Takao Saruta
Journal: Kidney International (2003)
Glutamine supplements in the critically ill
Authors: R. D'Souza, J. Powell-Tuck
Journal: Journal of the Royal Society of Medicine (2004)

Glutamine is a five-carbon neutral aminoacid containing two carboxyl groups one of which is bound to nitrogen, forming an amide group. It is the most abundant free aminoacid in the body.1 In the extracellular fluid it constitutes about 25% of the free aminoacid pool, in skeletal muscle more than 60%.1 A healthy 70 kg man contains 80 g of glutamine and the concentration of glutamine in his blood is 500–700 μmol/L.
Diagnosis of Conversion Reactions
Authors: Marjorie Raskin
Journal: JAMA (1966)

Eight psychiatric criteria were tested for their usefulness in distinguishing between conversion reactions and organic symptoms. Three were found most useful and can form a predictive index. They include (1) the patient's prior use of physical symptoms as a psychological defense, (2) the presence of a significant emotional stress prior to the onset of the symptom, and (3) evidence that the symptom was being used to solve a conflict brought about by the precipitating stress. These criteria can serve as additional data for the diagnosis of conversion reaction, and are useful in ruling out conversion reactions thus reopening the search for organic illness. The diagnosis of "hysteria" and the presence of a model for the symptom confirmed a conversion reaction. The presence of an hysterical personality, "la belle indifference," and the expression of symbolism in the symptom were not helpful.
Chronic Poisoning by Arsenic
Authors: A. T. H. Kerr
Journal: BMJ (1875)

ignited, charcoal-points, and electric heat, all of which either have some disadv'antage or are ineffectual.I believe nitric acid to possess these advantages as a caustic in uterine practice.It requires no special pre- parmition, and is always at hand; it cannot affect the system as may a salt of mercury; it does not spread like potassa cum calce, nor is its ac.tion so deep; it produces little or no pain, and no htemor-rhage.
Three cases of spontaneous duodeno-colic fistula
Authors: B. Torrance, C. Jones
Journal: Gut (1972)

Three cases of duodeno-colic fistula are presented, where a communication was demonstrated between the anterior aspect of the third part of the duodenum and the transverse colon at the point of mesocolic attachment. At operation the fistulae were found to be some 6 to 9 cm in length, and histological examination showed a well marked muscular layer with an intact epithelium. In view of the absence of any explanatory pathology, an embryological basis is suggested as the likeliest explanation for their origin.
Results of a randomized controlled trial on statin use in dialysis patients had no influence on statin prescription
Authors: Ngan N. Lam, Arsh K. Jain, Dan G. Hackam, Meaghan S. Cuerden, Rita S. Suri, Cindy Y. Huo, Ping Li, William F. Clark, Amit X. Garg
Journal: Kidney International (2009)
A METHOD FOR SERIAL SAMPLING OF BLOOD DURING SLEEP
Authors: JAMES L. MATHIS, BOYD K. LESTER, CHESTER M. PIERCE
Journal: American Journal of Psychiatry (1961)

An indwelling polyethylene tube in a large superficial vein offers a simple, safe, economical technique for obtaining serial blood samples without disturbing a sleeping subject. This permits study of hematological correlates of depth of sleep, diurnal and other periodic changes, and episodes of dreaming.
Sport and exercise headache: Part 2. Diagnosis and classification.
Authors: S J Williams, H Nukada
Journal: British Journal of Sports Medicine (1994)

A group of 129 subjects (67 men and 62 women) experiencing sports headache was established using a questionnaire. A wide range of information was gathered, focusing on the mode of onset, time course, characteristic features and associated symptoms of sports-related headache. Criteria for the varieties of sports headaches were established using head trauma and then migraine to divide subgroups of sports headaches. Cases were classified into four categories: effort migraine, trauma-triggered migraine, effort-exertion headache, and post-traumatic headache. The percentages of each sports-related headache found were: effort migraine 9%, trauma-triggered migraine 6%, effort-exertion headache 60%, post-traumatic headache 22% and miscellaneous 3%. Sports migraine accounted for 15% of the total sports headache sample. Effort-exertion headache was the most common type of sports headache. Although effort-exertion headache could be separated into subjects who had an acute severe headache induced by anaerobic exercise (exertion headache) from those having a substantial headache lasting hours initiated by aerobic exercise (effort headache), most subjects with effort-exertion headache in this study appeared not to fall into any discrete subgroups. Trauma-related headaches were experienced mainly by men in contact sports, while women more commonly had non-trauma-related headache in running and jogging.
BACTERIOLOGICAL AND EXPERIMENTAL STUDIES ON GASTRIC ULCER
Authors: Herbert L. Celler, William Thalhimer
Journal: The Journal of Experimental Medicine (1916)

It must be assumed that some cause is operative in certain cases preventing the healing of defects in the gastric mucosa and is inoperative in others. Even though anhemolytic streptococci are present in practically all gastric ulcers, we cannot convince ourselves that these organisms have been proven as yet to be the factor which either initiates the ulceration or prevents healing. Nevertheless, the constant presence of streptococci in this type of lesion is a suggestive fact and further experiments to determine their significance are being undertaken.
Palliative Radiotherapy Trials for Bone Metastases: A Systematic Review
Authors: Edward Chow, Kristin Harris, Grace Fan, May Tsao, Wai M. Sze
Journal: Journal of Clinical Oncology (2007)

Purpose The objective is to update previous meta-analyses with a systematic review of randomized palliative radiotherapy (RT) trials comparing single fractions (SFs) versus multiple fractions (MFs). Methods The analysis includes all published reports from randomized trials comparing SF or MF schedules for the treatment of painful bone metastases with localized RT. A systematic review was performed using the random-effects model with Review Manager version 4.1 (Cochrane Collaboration, Oxford, UK). The odds ratio and 95% CI were calculated for each trial and presented in a forest plot. Results A total of 16 randomized trials from 1986 onward were identified. For intention-to-treat patients, the overall response (OR) rates for pain were similar for SF at 1,468 (58%) of 2,513 patients and MF RT at 1,466 (59%) of 2,487 patients. The complete response (CR) rates for pain were 23% (545 of 2,375 patients) for SF and 24% (558 of 2,351 patients) for MF RT. No significant differences were found in response rates. Trends showing an increased risk for SF RT arm patients in terms of pathological fractures and spinal cord compressions were observed, but neither were statistically significant (P = .75 and P = .13, respectively). The likelihood of re-treatment was 2.5-fold higher (95% CI, 1.76 to 3.56) in SF RT arm patients (P &lt; .00001). Repeated analysis of these end points, excluding dropout patients, did not alter the conclusions. Generally, no significant differences with respect to acute toxicities were observed between the arms. Conclusion No significant differences in the arms were observed for overall and CR rates in both intention-to-treat and assessable patients. However, a significantly higher re-treatment rate with SFs was evident.
By their own young hand.
Authors: K. Hawton
Journal: BMJ (1992)

would not preclude later publication of a scientific paper because the presentation would be different and the original source not easily retrievable.Like other forms of "grey literature" these reports do not appear in widely available databases and indexes, and the information would be virtually unobtainable by someone who did not already know it existed-particularly someone outside Britain.Annual reports of directors of public health are also unlikely to cause problems, for similar reasons.
La suggestibilité et les caractères nationaux
Authors: J. Stuchlík
Journal: Psychotherapy and Psychosomatics (1967)

Research Articles| February 12 2010 La suggestibilité et les caractères nationaux Subject Area: Psychiatry and Psychology J. Stuchlík J. Stuchlík Prague Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1967) 15 (5): 358–369. https://doi.org/10.1159/000285903 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J. Stuchlík; La suggestibilité et les caractères nationaux. Psychother Psychosom 1 May 1967; 15 (5): 358–369. https://doi.org/10.1159/000285903 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
709 LONG-TERM TREATMENT WITH LAMIVUDINE UP TO TEN YEARS: PREDICTIVE VALUE OF HOST AND VIRUS RELATED RISK FACTORS FOR THE DEVELOPMENT OF HBV RESISTANCE
Authors: F. van Bömmel, A. Brodzinski, U. Mihm, M.C. Jung, C. Sarrazin, A. Bergk, B. Schlosser, V. Weich, T. Müller, E. Schott, B. Wiedenmann, T. Berg
Journal: Journal of Hepatology (2008)
Asbestos company is forced to fund compensation shortfall
Authors: Bob Burton
Journal: BMJ (2005)

Hit by a national boycott, the major Australian building products company James Hardie Industries has agreed to compensate people with diseases induced by its asbestos products by providing approximately $A1.5bn (£0.6bn; $1.2bn; €0.9bn) over a period of at least 40 years.

Under a heads of agreement negotiated with the Australian Council of Trade Unions and groups representing people with asbestos related diseases James Hardie will, for each year of the term agreed, provide up to 35% of the company's annual cash flow from its global operations to a special purpose fund. The number of new cases of diseases relating to the widespread use …
Evaluation of Myocardial Revascularization with Arterial Implants
Authors: W. E. Bloomer, M. H. Ellestad, A. J. Beland, J. A. Cope, E. R. Palarea
Journal: Annals of Internal Medicine (1970)

A study was made of 164 patients who had received systemic arterial implants for myocardial revascularization. This included 63 patients with a single Vineberg, 78 with a double Vineberg, and 23 in whom splenic artery implants had been performed with or without internal mammary artery implants. All had preoperative coronary arteriograms, and all but six had preoperative treadmill stress tests. Operative mortality was 6.7%. In 93 patients, all of whom had had positive stress tests preoperatively, comparison was made with postoperative stress tests 6 months to a year after operation. In 28% no ischemia could be demonstrated on maximal stress testing. In an additional 34.4% there was significant improvement. Postoperative angiography of the implants was obtained in 53 patients who had been studied by treadmill stress testing. The stress testing was found to be a more critical objective method of appraisal of functional improvement.
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms
Authors: Yoshihiro Onouchi, Tomohiko Gunji, Jane C Burns, Chisato Shimizu, Jane W Newburger, Mayumi Yashiro, Yoshikazu Nakamura, Hiroshi Yanagawa, Keiko Wakui, Yoshimitsu Fukushima, Fumio Kishi, Kunihiro Hamamoto, Masaru Terai, Yoshitake Sato, Kazunobu Ouchi, Tsutomu Saji, Akiyoshi Nariai, Yoichi Kaburagi, Tetsushi Yoshikawa, Kyoko Suzuki, Takeo Tanaka, Toshiro Nagai, Hideo Cho, Akihiro Fujino, Akihiro Sekine, Reiichiro Nakamichi, Tatsuhiko Tsunoda, Tomisaku Kawasaki, Yusuke Nakamura, Akira Hata
Journal: Nature Genetics (2007)
EYE SYMPTOMS AND CONDITIONS IN BRIGHT'S DISEASE.
Authors: WM. S. LITTLE
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Worsening of heart failure during hospital course of an unselected cohort of 2507 patients with myocardial infarction is a factor of poor prognosis: the PRIMA study
Authors: Guy de Gevigney, René Ecochard, Muriel Rabilloud, Sandrine Gaillard, Edouard Cheneau, Corinne Ducreux, Danièle Cao, Hugues Milon, François Delahaye
Journal: European Journal of Heart Failure (2001)
Searching for a Biomarker for Ovarian Cancer
Authors: James Allen Roberts
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL TREATMENT OF PITUITARY NEOPLASM
Authors: IRVING H. PARDEE
Journal: JAMA (1925)

The frequency of unsuccessful operations on tumors of the hypophysis has led us to search for a method of approach that is less hazardous. Two fields seemed open—that of glandular therapy and that of radiotherapy.  The average benign enlargement of the pituitary gland will proceed along a certain stereotyped course. Ushered in by headaches, there will be a progressive enlargement of the gland, resulting in a constant pressure on the walls of the sella turcica. This fossa will enlarge according to the size of its contained tumor until symptoms of pressure on surrounding brain structures appear. Depending on the direction this growth takes, signs of pressure will develop. Associated with this there may or may not be signs of tissue changes or biochemical disorder, due to disturbance of the internal secretory mechanism of the pituitary or of a closely related gland.  The entire course tends toward recovery. Other endocrine glands
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
Authors: Ryo Sumazaki, Nobuyoshi Shiojiri, Shigemi Isoyama, Masayuki Masu, Kazuko Keino-Masu, Mitsujiro Osawa, Hiromitsu Nakauchi, Ryoichiro Kageyama, Akira Matsui
Journal: Nature Genetics (2003)
The effect of FGF-1 loaded alginate microbeads on neovascularization and adipogenesis in a vascular pedicle model of adipose tissue engineering
Authors: Monica L. Moya, Ming-Huei Cheng, Jung-Ju Huang, Megan E. Francis-Sedlak, Shu-wei Kao, Emmanuel C. Opara, Eric M. Brey
Journal: Biomaterials (2010)