tbuckley/cabot-search huggingface dataset:
SYMPATHECTOMY IN BRONCHIAL ASTHMA
Authors: Maximilian A. Ramirez
Journal: JAMA (1925)

The favorable report of Kümmell<sup>1</sup>on resection of the cervical sympathetic ganglion in bronchial asthma led us to attempt this procedure in two severe cases of asthma. The patients had been under observation by one of us for a number of years in the clinic of the French Hospital. No improvement had resulted from the usual methods of treatment. In selecting cases for sympathectomy, we desire to stress the necessity of doing a very complete test against all available proteins, as only nonallergic cases should be subjected to this method of treatment. <h3>REPORT OF CASES</h3><h3>Case 1.—History.</h3> —J. C., a man, aged 55, had had frequent attacks of coughing, dyspnea and profuse expectoration for twenty-nine years. He had had periods of remission and felt fairly well. For the past few years, shortness of breath had been quite constant, and he had attacks of coughing almost every night. The
INSULIN SENSITIZING THERAPY COMPARED TO INSULIN PROVIDING THERAPY FOR TYPE 2 DIABETES MELLITUS: EFFECTS ON LOW DENSITY LIPOPROTEIN PARTICLE CHARACTERISTICS BY NUCLEAR MAGNETIC RESONANCE LIPOPROFILE-III
Authors: Trevor J. Orchard, David Robertson, Marnie Bertolet, James Otvos, Tom Donner, Teik Ooi, Georgia Pambianco, Jamal Rana, Donald Smith, Lynn Zoiopoulos
Journal: Journal of the American College of Cardiology (2010)
Serum Transaminases during Salicylate Therapy
Authors: A. S. Russell, R. A. Sturge, M. A. Smith
Journal: BMJ (1971)

In 8 out of 32 juvenile patients suffering from chronic polyarthritis and in one patient with dermatomyositis, raised transaminase levels were found; the salicylate level was above 35 mg/100 ml in all except one. Reduction in the salicylate level led to a prompt fall in the serum transaminases. Despite a rise in alkaline phosphatase in three cases there was no other evidence of liver dysfunction in the children. Only one of the adults showed a rise in transaminase levels, and she had mild cirrhosis.
A1.23 Lasp-1 deficiency modifies synovial fibroblast migration and cartilage destruction in a model of HTNF alpha mediated arthritis
Authors: Denise Beckmann, Jan Hillen, Marianne Heitzmann, Catherine S Chew, Stefan Butz, Dietmar Vestweber, Hermann Pavenstädt, Thomas Pap, Adelheid Korb-Pap
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background and Objectives</h3> Lasp-1 is an important actin-crosslinking protein. It's localises at focal adhesions, along stress fibres and leading edges and is involved in cellular migration and metastatic dissemination of different cancers. Rheumatoid arthritis synovial fibroblasts (RASF) are also able to enter the bloodstream from sites of cartilage destruction to new locations where they re-initiate the destructive processes. The underlying mechanisms of this process are of special interest, but currently unclear. Therefore we have investigated the role of Lasp-1 in synovial fibroblast migration during RA. <h3>Materials and Methods</h3> Lasp-1 expression and its subcellular location was analysed using Western blotting and immunofluorescence microscopy of cells seeded on various coatings, including fibronectin, laminin and a self-purified collagen matrix. Furthermore, Lasp-1 deficient mice were generated, which were interbred with hTNFtg mice, to form a model of inflammatory arthritis. Mice of all genotypes were analysed using a clinical score, measuring weight, grip strength and paw swelling over a time course of 14 weeks. Hind paws from each genotype were isolated, paraffin-embedded and toluidine blue stained in order to assess synovial inflammation, cartilage degradation and SF attachment. Cell migration properties of SFs derived from WT, Lasp-1<sup>-/-</sup>, hTNFtg and Lasp1<sup>-/-</sup>/hTNFtg were measured using a modified scratch assay and by live cell imaging. <h3>Results</h3> Lasp-1 expression was up regulated in RASF and in SF from hTNFtg mice compared to healthy controls. In immunofluorescence, Lasp-1 was co-localised with cortactin, a marker for structures of cell adhesion and invasion, particularly when cultured on a purified collagen matrix. Lasp1<sup>-/-</sup>/hTNFtg mice showed milder clinical symptoms in comparison to hTNFtg mice. Notably, histopathological analyses revealed less cartilage destruction (0.4 mm vs. 1.6 mm, p&lt;0.05) and less attachment of synovial tissue to the cartilage surface (5% vs. 35%, p&lt;0.05) in Lasp1<sup>-/-</sup>/hTNFtg mice at 14 weeks of age. Lasp-1<sup>-/-</sup> SFs and Lasp1<sup>-/-</sup>/hTNFtg SFs exhibited a significantly reduced migration rate in comparison to WT and hTNFtg SFs, with significant differences observed in cell migration speed, cell spreading and in the formation of stress fibres and filopodia. <h3>Conclusion</h3> Lasp-1 deficiency leads to significantly reduced migration rates of RASF and hTNFtg SF <i>in vitro</i> and results in a decreased cartilage degradation and destruction and less SF attachment to articular cartilage in hTNFtg mice <i>in vivo</i>. Therefore, Lasp-1 is an important target for therapeutic strategies aimed to reduce the invasive and migratory behaviour of synovial fibroblast in rheumatoid arthritis.
Infarct resorption, compensatory hypertrophy, and differing patterns of ventricular remodeling following myocardial infarctions of varying size
Authors: David S. Fieno, Hanns B. Hillenbrand, Wolfgang G. Rehwald, Kathleen R. Harris, Robert S. Decker, Michele A. Parker, Francis J. Klocke, Raymond J. Kim, Robert M. Judd
Journal: Journal of the American College of Cardiology (2004)
Absolute Risk Models for Subtypes of Breast Cancer
Authors: M. H. Gail, W. F. Anderson, M. Garcia-Closas, M. E. Sherman
Journal: JNCI Journal of the National Cancer Institute (2007)

JNCI | Editorials 1657 Statistical models developed to predict the absolute risks of breast cancer subtypes may help identify women who could benefit from specific preventive interventions and improve estimates of total breast cancer risk. Chlebowski et al. ( 1 ) present data from the observational study and clinical trial cohorts of the Women’s Health Initiative (WHI) to evaluate and improve absolute risk prediction models for estrogen receptor (ER) – positive and – negative invasive breast cancer among women aged 50 – 79 years. They evaluate how well the Gail model [model 2 in Costantino et al. ( 2 )] predicts the numbers of breast cancers in the combined observational study and clinical trial cohorts (i.e., calibration) and the Gail model’s discriminatory accuracy, expressed as the area under the receiver operating curve (AUC), in the clinical trial population. They examine whether models with many risk factors can improve discriminatory accuracy and propose parsimonious models. Although they found that the AUC for the Gail model for all invasive cancer was 0.60, which is in line with previous validation studies ( 2 , 3 ), they reported AUC values of 0.58 for ER-positive breast cancer but only 0.50 for ER-negative breast cancer. The similarity in AUC values for ER-positive disease and for all invasive breast cancers may reflect the fact that most invasive breast cancer in women ag ed 50 – 79 years is ER positive (see Fig. 1 ).
Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity.
Authors: D J Jenkins, T M Wolever, A R Leeds, M A Gassull, P Haisman, J Dilawari, D V Goff, G L Metz, K G Alberti
Journal: BMJ (1978)

To define the type of dietary fibre of fibre analogue with the greatest potential use in diabetic treatment, groups of four to six volunteers underwent 50-g glucose tolerance tests (GTT) with and without the addition of either guar, pectin, gum tragacanth, methylcellulose, wheat bran, or cholestyramine equivalent to 12 g fibre. The addition of each substance significantly reduced blood glucose concentration at one or more points during the GTT and generally reduced serum insulin concentrations. The greatest flattening of the glucose response was seen with guar, but this effect was abolished when hydrolysed non-viscous guar was used. The reduction in the mean peak rise in blood glucose concentration for each substance correlated positively with its viscosity (r = 0.926; P less than 0.01), as did delay in mouth-to-caecum transit time (r = 0.885; P less than 0.02). Viscous types of dietary fibre are therefore most likely to be therapeutically useful in modifying postprandial hyperglycaemia.
Clustering of risk factors and social class in childhood and adulthood in British women's heart and health study: cross sectional analysis
Authors: Shah Ebrahim, David Montaner, Debbie A Lawlor
Journal: BMJ (2004)

<h3>Abstract</h3> <b>Objective</b> To examine co-occurrence and clustering of risk factors used in the Framingham equation by social class in childhood and adult life. <b>Design</b> Cross sectional study. <b>Setting</b> 23 towns across England, Wales, and Scotland. <b>Participants</b> 2936 women aged 60-79 years. <b>Main outcome measures</b> Prevalence of risk factors (hypertension, obesity, smoking, left ventricular hypertrophy on electrocardiography, diabetes, and low concentration of high density cholesterol); ratios of observed to expected frequencies of clusters of risk factors. <b>Results</b> Risk factors were more common in women from manual social classes in either childhood or adult life, and the co-occurrence of three or four of these risk factors was greater among more disadvantaged groups. Within the four socioeconomic groups, these risk factors occurred together more than would be expected from their individual frequency distributions, indicating that they were clustered. The extent of this clustering was similar in all four social class groups. <b>Conclusions</b> Clustering of risk factors included in the Framingham risk function occurs in all social class groups, but the lack of social patterning makes it unlikely that clustering is an explanation of socioeconomic inequalities in cardiovascular disease. As the proportion of women with co-occurrence of risk factors is greatest in those from manual social class in childhood, this measure of socioeconomic position might prove useful in risk prediction.
Characterization of Beta3-Adrenoceptors in Human Internal Mammary Artery and Putative Involvement in Coronary Artery Bypass Management
Authors: Bertrand Rozec, Sabrina Serpillon, Gilles Toumaniantz, Camille Sèze, Yohann Rautureau, Olivier Baron, Jacques Noireaud, Chantal Gauthier
Journal: Journal of the American College of Cardiology (2005)
Human Reproduction: Conception and Contraception
Authors: Larry McGowan
Journal: JAMA (1973)

This single volume attempts to summarize pertinent literature of human conception and contraception. To accomplish this difficult task, the authors and contributors divided 33 chapters into five major divisions. The first, parameters of human fertility, brings together basic knowledge regarding spermatogenesis and oogenesis, gamete transport, fertilization, implantation, and the reproductive life cycle. The second section, fertility inhibition, contains clinically oriented chapters on ovulation detection, female barrier contraceptives, intrauterine devices, sterilization of men and women, termination of pregnancy, and the oral contraceptives. It is of interest that on page 347 the association of oral contraceptives and thromboembolism is rejected, whereas on page 555 we find "the reality of association between drug use and a significant increase in both mortality and morbidity from thromboembolic disease." Consequences of fertility inhibition constitute the third division of the text, covering such interesting topics as metabolic and vascular effects of oral contraceptives and consequences of termination
Safety, humoral and cell-mediated immune responses to herpes zoster vaccine in subjects with diabetes mellitus
Authors: Atsuko Hata, Fukue Inoue, Midori Yamasaki, Jun Fujikawa, Yukiko Kawasaki, Yoshiyuki Hamamoto, Sachiko Honjo, Eiko Moriishi, Yasuko Mori, Hiroyuki Koshiyama
Journal: Journal of Infection (2013)
INTERACTION BETWEEN ALCOHOL HABIT AND GENE POLYMORPHISM OF NEUROPEPTIDE Y ON THE RISK OF ESSENTIAL HYPERTENSION
Authors: Masahiko Eto, Masanobu Okayama, Maki Kumada, Taro Takeshima, Takanori Aonuma, Yoshikazu Nakamura, Kajii Eiji
Journal: Journal of the American College of Cardiology (2014)
Is there a sex difference in the balance of pain excitatory and pain inhibitory processes?
Authors: Stefan Lautenbacher
Journal: Behavioral and Brain Sciences (1997)

According to berkley 's review, women have a higher risk of suffering from pain than men. If this is true, there should be more frequent and more intense activity both in the pain excitatory system and in the pain inhibitory system of women than of men. Consequently, it remains unclear whether the overall effect at the end is more pain or less pain in women. This conclusion fits the weak sex differences observed for experimental and clinical pain as shown by berkley 's review of the literature.
Reversed Form of Differential Collapsing Pulses
Authors: Tsung O. Cheng
Journal: Annals of Internal Medicine (1994)

Letters15 January 1994Reversed Form of Differential Collapsing PulsesTsung O. Cheng, MDTsung O. Cheng, MDThe George Washington University; Washington, DC 20037Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-2-199401150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The report of collapsing pulses in both lower limbs but not in the upper limbs [1] reminded me of a reversed phenomenon in a patient I encountered as a medical resident.A 25-year-old woman was hospitalized for evaluation of severe hypertension and fever 3 weeks after dental extraction. Physical examination at the time of hospitalization showed the blood pressures in both arms to be 190/60 mm Hg, collapsing pulses in both arms, and an early diastolic blowing murmur at the Erb point. The patient reported a history of hypertension and a heart murmur since early childhood. Further ...REFERENCE1. O'Sullivan J, Bain H. Differential collapsing pulses: a new clinical sign (Letter). Ann Intern Med. 1993; 119:540. Google Scholar Author, Article, and Disclosure InformationAffiliations: The George Washington University; Washington, DC 20037 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1994Volume 120, Issue 2Page: 167KeywordsAortic valveCongenital heart diseaseDecision makingDrug therapyEndocarditisFeversHeart murmursHeart rateHospitalizationsHypertension Issue Published: 15 January 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Caffeine and Incident Hypertension in Women
Authors: Paolo Palatini
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selected Papers of Charles H. Best. (On insulin and diabetes; heparin and thrombosis; choline and liver damage.)
Authors: Thomas G. Skillman
Journal: JAMA (1963)

In this volume any physician would expect to find the exciting and historic documents which describe the brief era preceding the successful extraction of insulin and the stirring records of its initial effects in human diabetics. He would also expect the subsequent reports, detailing a continued and comprehensive investigation of experimental diabetes. However, those unaware of the enormous energy and intellectual curiosity of Dr. Best are surprised to find almost equally significant accounts of his contributions to the fields of fat metabolism and lipotropic factors, and thrombosis and anticoagulants. The book is prefaced with a foreword by Sir Henry Dale and an introduction by Elliott P. Joslin. Its 64 papers are divided into four major sections, but the first two, discussing "Insulin and Glucagon" and "Choline and Lipotropic Factors," account for two thirds of the content. In each section there is a chronologic sequence. Dr. Best personally annotated most of
Teratological research using in vitro systems. III. Embryonic organs in culture.
Authors: K E Whitby
Journal: Environmental Health Perspectives (1987)

A search of literature published through the spring of 1986 yielded approximately 95 citations for the following embryonic organs in culture: kidney, pancreas, skin, palate, craniofacial tissue, tooth, lens, bones, digits, and liver. However, only the in vitro organ culture of the palate and tooth are reviewed in this paper. The other organ culture systems were not reported as teratogenic screens. Although some organs may have the potential for such use, many are currently used for evaluation of the pathogenesis associated with congenital abnormalities, cancer, or transplacental carcinogenesis, or in studies of the structure and function of differentiating organs, and will not be included in this review.
Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry site–mediated translation via phosphatidylinositol 3-kinase pathway in human factor–dependent leukemic cells
Authors: Norihiko Kobayashi, Kumiko Saeki, Akira Yuo
Journal: Blood (2003)
Drinks industry has learnt from tobacco companies, study says
Authors: M. Sweet
Journal: BMJ (2010)

Alcohol and tobacco companies have worked closely to share information and strategies in their fight against public health initiatives, a new Australian study says.

The researchers analysed 29 alcohol related documents retrieved from the millions of confidential tobacco industry papers that have been published online as a result of the Master Settlement Agreement in the United States in 1998, an agreement between four tobacco firms and the attorneys general of 46 US states. 

The study, published in the Australasian Medical Journal this week (doi:10.4066/AMJ.2010.363), found that the two industries used similar marketing strategies, including product placement and targeting young people and specific ethnic groups.

“They develop and provide potentially counterproductive public education campaigns so as to appear socially responsible and in an effort to deflect tighter controls on products,” the researchers said.

“Further, it can be drawn from these documents that …
Risk of Intussusception Following Administration of a Pentavalent Rotavirus Vaccine in US Infants
Authors: Irene M. Shui, James Baggs, Manish Patel, Umesh D. Parashar, Melisa Rett, Edward A. Belongia, Simon J. Hambidge, Jason M. Glanz, Nicola P. Klein, Eric Weintraub
Journal: JAMA (2012)

Current rotavirus vaccines were not associated with intussusception in large prelicensure trials. However, recent postlicensure data from international settings suggest the possibility of a low-level elevated risk, primarily in the first week after the first vaccine dose.To examine the risk of intussusception following pentavalent rotavirus vaccine (RV5) in US infants.This cohort study included infants 4 to 34 weeks of age, enrolled in the Vaccine Safety Datalink (VSD) who received RV5 from May 2006-February 2010. We calculated standardized incidence ratios (SIRs), relative risks (RRs), and 95% confidence intervals for the association between intussusception and RV5 by comparing the rates of intussusception in infants who had received RV5 with the rates of intussusception in infants who received other recommended vaccines without concomitant RV5 during the concurrent period and with the expected number of intussusception visits based on background rates assessed prior to US licensure of the RV5 (2001-2005).Intussusception occurring in the 1- to 7-day and 1- to 30-day risk windows following RV5 vaccination.During the study period, 786,725 total RV5 doses, which included 309,844 first doses, were administered. We did not observe a statistically significant increased risk of intussusception with RV5 for either comparison group following any dose in either the 1- to 7-day or 1- to 30-day risk window. For the 1- to 30-day window following all RV5 doses, we observed 21 cases of intussusception compared with 20.9 expected cases (SIR, 1.01; 95% CI, 0.62-1.54); following dose 1, we observed 7 cases compared with 5.7 expected cases (SIR, 1.23; 95% CI, 0.5-2.54). For the 1- to 7-day window following all RV5 doses, we observed 4 cases compared with 4.3 expected cases (SIR, 0.92; 95% CI, 0.25-2.36); for dose 1, we observed 1 case compared with 0.8 expected case (SIR, 1.21; 95% CI, 0.03-6.75). The upper 95% CI limit of the SIR (6.75) from the historical comparison translates to an upper limit for the attributable risk of 1 intussusception case per 65,287 RV5 dose-1 recipients.Among US infants aged 4 to 34 weeks who received RV5, the risk of intussusception was not increased compared with infants who did not receive the rotavirus vaccine.
Feasibility and Preliminary Clinical Outcomes of Robotic Laparoendoscopic Single-Site (R-LESS) Pyeloplasty Using a New Single-Port Platform
Authors: Andrea Cestari, Nicolò Maria Buffi, Giuliana Lista, Giovanni Lughezzani, Alessandro Larcher, Massimo Lazzeri, Mattia Sangalli, Patrizio Rigatti, Giorgio Guazzoni
Journal: European Urology (2012)
Acne conglobata responding to buserelin, a gonadotrophin-releasing hormone analogue
Authors: J. WAXMAN, M.H.A. RUSTIN, L. PERRY, J.D.T. KIRBY
Journal: British Journal of Dermatology (1983)

Journal Article Acne conglobata responding to buserelin, a gonadotrophin‐releasing hormone analogue Get access J. WAXMAN, J. WAXMAN Department of Medical Oncology and the Institute of Urology, St Bartholomew's Hospital, West Smithfield, London EC1A7BE Search for other works by this author on: Oxford Academic Google Scholar M.H.A. RUSTIN, M.H.A. RUSTIN Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London EC1A7BE Search for other works by this author on: Oxford Academic Google Scholar L. PERRY, L. PERRY Department of Chemical Endocrinology, St Bartholomew's Hospital, West Smithfield, London EC1A7BE Search for other works by this author on: Oxford Academic Google Scholar J.D.T. KIRBY J.D.T. KIRBY Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London EC1A7BE Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 109, Issue 6, 1 December 1983, Pages 679–681, https://doi.org/10.1111/j.1365-2133.1983.tb00550.x Published: 01 December 1983 Article history Accepted: 08 June 1983 Published: 01 December 1983