tbuckley/cabot-search huggingface dataset:
Diabetes and Oral Tumors in Hungary
Authors: Márta Ujpál, Orsolya Matos, György Bíbok, Anikó Somogyi, György Szabó, Zsuzsanna Suba
Journal: Diabetes Care (2004)

OBJECTIVE—Numerous publications have already demonstrated that diabetes is a risk factor for the development of periodontal diseases and various inflammatory lesions in the oral mucosa. A possible correlation between diabetes and oral premalignancies and tumors was examined in this study, as no literature data are available concerning this problem. RESEARCH DESIGN AND METHODS—Stomato-oncological screening was carried out on 200 diabetic patients in the medical departments; the control group included 280 adult dentistry outpatients. The lesions found were classified into three groups: inflammatory lesions, benign tumors, and precancerous lesions. A retrospective diabetes screening of 610 inpatients with histologically confirmed oral malignancies was also performed. The control group comprised 574 complaint- and tumor-free adults. Fasting blood glucose levels were determined in both groups, and the tumor location was registered in the cancer patients. RESULTS—Benign tumors were found in 14.5% and precancerous lesions in 8% of diabetic patients. In the control group these values were significantly lower, at 6.4 and 3.2%, respectively (P &amp;gt; 0.01). Earlier Hungarian screening studies indicated similar frequency of these lesions in the general population. The proportion of oral cavity lesions was higher among diabetic patients compared with that of the control patients. In the oral cancer patient group, diabetes was present in 14.6% and an elevated blood glucose level in 9.7%. These values are significantly higher than those for the tumor-free control group (P &amp;lt; 0.01). The gingival and labial tumor location was significantly more frequent among diabetic cancer patients than in the nondiabetic group (P &amp;lt; 0.01). The combination of diabetes and smoking means a higher risk for oral precancerous lesions and malignancies. CONCLUSIONS—Diabetes may be a risk factor for oral premalignancies and tumors.
Improved Internal Defibrillation Success With Shocks Timed to the Morphology Electrogram
Authors: William Hsu, Yayun Lin, Douglas J. Lang, Janice L. Jones
Journal: Circulation (1998)

Background —A previous retrospective study by our group suggested that shocks timed to the upslope of the shocking lead electrogram improved defibrillation efficacy. The goal of this study was to prospectively determine whether defibrillation threshold could be reduced by use of an algorithm that timed shocks to the upslope of coarse ventricular fibrillation (test treatment) compared with shocks delivered asynchronously after 10 seconds of fibrillation (control treatment). Methods and Results —Ten pigs were instrumented with a 3-lead system for internal defibrillation. Initial estimates of the energy required to achieve defibrillation E 50 for both treatments were made by an up/down method. Subsequently, additional shocks at V 50 ±10% and V 50 ±20% were given for each treatment to obtain data points at higher and lower intensities. Probability-of-success curves were estimated for both treatments by the best-fit method. Energies required were significantly lower for the timed shocks than for the asynchronous shocks ( P &lt;0.001). E 80 was reduced 15.5%, from 27.1±2.5 to 22.9±1.8 J ( P &lt;0.002). The width of the probability-of-success curve (E 80 −E 20 ) for the test treatment was also significantly narrower than that for the control treatment (7.1±0.9 versus 10.8±1.7, P &lt;0.01). Normalized curve width (E 80 −E 20 )/E 50 was decreased from 51±5% of E 50 for control shocks to 37±4% of E 50 for synchronous shocks ( P &lt;0.02). Conclusions —In this model, defibrillation threshold is lower and more deterministic when shocks are timed to the upslope of the shocking lead electrogram. If a similar reduction is observed in humans, shock timing may lower defibrillation threshold and simplify programming of shock intensity.
248 ANALYSIS AND CHARACTERIZATION OF HBVDNA INTEGRATION IN PATIENTS WITH OCCULT HBV INFECTION AND HEPATOCELLULAR CARCINOMA
Authors: C. Saitta, T. Pollicino, G. Raffa, A. Bertuccio, A. Barbera, A. Ciancio, A. Smedile, G. Navarra, G. Raimondo
Journal: Journal of Hepatology (2011)
Through the Viewing Tube: Videocassette Psychiatry
Authors: DAVID V. FORREST, JAMES H. RYAN, RICHARD GLAVIN, H. HOUSTON MERRITT
Journal: American Journal of Psychiatry (1974)

The authors, who have been exploring the potential of videotape presentations for psychiatric education, discuss the issues that have arisen since they began developing their "Electronic Textbook of Psychiatry." They consider such questions as the adequacy of the television image in capturing emotion and transmitting information, the ideal length of the taped segment, and the flexibility and limits of the medium. They conclude that videotape presentation may (as have dream interpretation. psychometrics, linguistics, and other useful approaches to behavior) contribute to our conception of mental disorders.
Electronic Health Records in the Age of Social Networks and Global Telecommunications
Authors: Aviv Shachak, Alejandro R Jadad
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endothelin and angiotensin II stimulation of Na+-H+ exchange is impaired in cardiac hypertrophy.
Authors: N Ito, Y Kagaya, E O Weinberg, W H Barry, B H Lorell
Journal: Journal of Clinical Investigation (1997)

We compared the effects of endothelin-1 (ET-1) on intracellular pH, intracellular [Ca2+]i, and cell contraction in hypertrophied adult ventricular myocytes from ascending aortic banded rats and age-matched controls. Intracellular pH (pH(i)) was measured in individual myocytes with SNARF-1, and [Ca2+]i was measured with indo-1, simultaneous with cell motion. Experiments were performed at 36 degrees C in myocytes paced at 0.5 Hz in Hepes-buffered solution (pH(o) 7.40) containing 1.2 mM CaCl2. At baseline, calibrated pH(i), diastolic and systolic [Ca2+]i values, and the amplitude of cell contraction were similar in hypertrophied and control myocytes. Exposure of the control myocytes to 10 nM ET-1 caused an increase in the amplitude of cell contraction to 163+/-22% of baseline (P < 0.05), associated with intracellular alkalinization (pH(i) + 0.08+/-0.02 U, P < 0.05) and a slight increase in peak systolic [Ca2+]i (104+/-11% of baseline, P < 0.05). In contrast, in the hypertrophied myocytes, exposure to ET-1 did not increase the amplitude of cell contraction or cause intracellular alkalinization (-0.01+/-0.02 U, NS). Similar effects were observed in the hypertrophied and control myocytes in response to exposure to 10 nM angiotensin II. ET-1 also increased the rate of recovery from intracellular acidosis induced by the washout of NH4Cl in the control cells, but did not do so in the hypertrophied cells. In the presence of 10 microM 5-(N-ethyl-N-isopropyl)-amiloride, which inhibits Na+-H+ exchange, ET-1 did not cause a positive inotropic effect or intracellular alkalinization in control cells. The activation of protein kinase C by exposure to phorbol ester caused intracellular alkalinization and it increased the rate of recovery from intracellular acidification induced by an NH4Cl pulse in control cells but not in hypertrophied cells. ET-1, as well as angiotensin II, and phorbol ester, fail to stimulate forward Na+-H+ exchange in adult hypertrophied myocytes. These data suggest a defect in the coupling of protein kinase C signaling with Na+-H+ exchange in adult hypertrophied myocytes.
Role of Olivary Electrical Coupling in Cerebellar Motor Learning
Authors: Ruben S. Van Der Giessen, Sebastiaan K. Koekkoek, Stijn van Dorp, Jornt R. De Gruijl, Alexander Cupido, Sara Khosrovani, Bjorn Dortland, Kerstin Wellershaus, Joachim Degen, Jim Deuchars, Elke C. Fuchs, Hannah Monyer, Klaus Willecke, Marcel T.G. De Jeu, Chris I. De Zeeuw
Journal: Neuron (2008)
Tensile destruction test as an estimation of partial proteolysis in fibrin clots
Authors: Enrique Saldívar, Jennifer N. Orje, Zaverio M. Ruggeri
Journal: American Journal of Hematology (2002)

Abstract We report a technique devised to evaluate the effects of partial proteolysis on the mechanical characteristics of acellular non‐cross‐linked fibrin clots. The destruction technique applies coaxial tension on mechanically preconditioned cylindrical molded clots and measures the number of mechanical failures vs the total number of samples at a given load (2, 3, and 4 grams force). We used different plasmin concentrations (0, 0.01, 0.02, 0.04, and 0.08 U/mL) in the bathing medium to cause partial proteolysis. We monitored the fibrinolysis process by measuring the amount of protein released in the bathing medium. Our results showed no difference in the creep function in all the groups studied. We compare our technique with compaction, a commonly used mechanical technique that compresses the sample by centrifugation, and found that our technique is capable of detecting minor changes of fibrinolysis (the results of the least square fit for the destruction test at 2 grams force, as a function of plasmin concentration, has a coefficient of determination of R 2 = 0.55), while compaction did not show a statistically significant difference in the same conditions, suggesting that each individual fibrin fiber bears load only under tension. Our findings suggest that when the fibers are cleaved their capacity to withstand stress is seriously challenged; thus, in principle, tensile destruction test can detect a minimal degree of proteolysis. Am. J. Hematol. 71:119–127, 2002. © 2002 Wiley‐Liss, Inc.
Electrophysiological effects of thoracic epidural analgesia in the dog heart in situ
Authors: R. HOTVEDT, E. S PLATOU, H. REFSUM
Journal: Cardiovascular Research (1983)

Journal Article Electrophysiological effects of thoracic epidural analgesia in the dog heart in situ Get access RAGNAR HOTVEDT, RAGNAR HOTVEDT * From the Institute of Medical Biology, University of Tromsø, Tromsø, Norway *Reprint requests to: Ragnar Hotvedt MD, Physiological Section, Institute of Medical Biology, University of Tromsø, N-9000 Tromsø, Norway. Search for other works by this author on: Oxford Academic PubMed Google Scholar EIVIND S PLATOU, EIVIND S PLATOU From the Institute of Medical Biology, University of Tromsø, Tromsø, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar HELGE REFSUM HELGE REFSUM From the Institute of Medical Biology, University of Tromsø, Tromsø, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 17, Issue 5, May 1983, Pages 259–266, https://doi.org/10.1093/cvr/17.5.259 Published: 01 May 1983
OBSERVATIONS IN THE USE OF DIPHTHERIA ANTITOXIN, WITH SPECIAL REFERENCE TO ITS USE IN MALIGNANT CASES.
Authors: ALEXANDER McALISTER
Journal: JAMA (1897)

In bringing this subject before you it is my purpose to confine myself to those features of the disease which demonstrate the rationale of the serum treatment, as now recommended by all leading clinicians. The development of the bacillus of Löffler in a susceptible individual constitutes diphtheria in its primary form. The seat of development, a local lesion, is usually the mucous surface of the respiratory tract, but may be any mucous surface or flesh wound of the body. The medium of infection is atmospheric air, and the portions of the body most exposed are the tonsils because of their structure, function and situation. It is important in this connection to recall the anatomy of the tonsils. They are racemose glands, covered with reduplications of the oral mucous membrane. Their inner surface presents from twelve to fifteen orifices leading into small recesses, from which numerous follicles branch out into the
Assessment of oxidative metabolism in adults with hepatocellular carcinoma in the Sudan.
Authors: M M Homeida, T K Daneshmend, E M Ali, A G Yousif-Elkadaru, B M Arbab
Journal: Gut (1986)

The hypothesis that an increased rate of oxidative metabolism may be an initiator or promoter of hepatocellular carcinoma was tested in vivo. Elimination of antipyrine (phenazone) was used as an index of the activity of microsomal mixed function oxidative enzymes. Plasma antipyrine kinetics were examined in 10 patients with hepatocellular carcinoma and in 10 normal Sudanese adults. The half life, volume of distribution and clearance of antipyrine in patients were 18.8 +/- 7.9 hours (mean +/- SD), 33.8 +/- 7.7 litres and 23.7 +/- 10.1 ml/min, respectively; and in normal adults were 20.3 +/- 8.8 hours, 40.1 +/- 10.4 litres and 25.7 +/- 12.0 ml/min, respectively. These differences were not significant. Antipyrine plasma clearance when corrected for weight was similar in the two groups. This study suggests that in a population at risk for hepatocellular carcinoma, the overall activity of mixed function oxidative enzymes is not an important determinant in selectively increasing this risk.
Measuring ventilation of patient care areas in hospitals. Description of a new protocol.
Authors: R Menzies, K Schwartzman, V Loo, J Pasztor
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

It has been recommended that ventilation of health care facilities should be monitored regularly to reduce the risk of nosocomial transmission of tuberculosis. We developed a simple method to measure air-change rates and direction of airflow in patient care areas. Pure carbon dioxide (CO2) was released at 13.5 L/min for 5 min, then measured for 30 min within the room and outside in the hallway. Smoke tubes were also used to measure direction of airflow. Doors and windows (if openable) were manipulated. This protocol, when conducted in five offices in 30 patients care areas in two hospitals, provided good mixing and reproducible decay curves, with less than 15% coefficient of variation for repeated measures over a wide range of air-change rates. Manipulation of door and/or window produced significant changes in air-change rates and airflow direction, although calculated air-change rates were more variable. Smoke tube measurements were inconsistent, agreed poorly with evidence of CO2 movement from room to hall, and were strongly affected by room to hallway temperature differentials. CO2 release and measurement proved to be a simple, yet reliable, method to measure air-change rates and the effect of door or window manipulation. Smoke tube measurements were not reliable to characterize direction of airflow.
Specificity of antinuclear antibodies in primary biliary cirrhosis.
Authors: M.J. Chou, S.L. Lee, T.Y. Chen, G.J. Tsay
Journal: Annals of the Rheumatic Diseases (1995)

OBJECTIVE--To study the specific autoantibodies against nuclear antigens in patients with primary biliary cirrhosis (PBC). METHODS--Sera from 21 patients with PBC were tested for antinuclear antibody (ANA) by indirect immunofluorescence on human epithelial (HEp)-2 cells, and for antibodies to various nuclear antigens by enzyme linked immunosorbent assay (ELISA) using different purified proteins or recombinant proteins as antigens. RESULTS--ANA detected in 10 of 21 patients (48%) with PBC included five anti-centromere antibody (ACA), two speckled, two homogeneous and one nuclear dot staining. ACA were present in 24% of PBC patients. By ELISA, anti-histone antibodies were detected in 81% of PBC patients, anti-ssDNA antibodies in 71% and anti-dsDNA in 10%, anti-topoisomerase-1 antibodies in 24%, anti-Sm/RNP antibodies in 24%, anti-La-48(SS-A) antibodies in 21%, and anti-Ro-60(SS-A) and anti-Ro-52(SS-A) antibodies in 30% and 25%, respectively. CONCLUSIONS--The high frequencies of various antibodies directed against intracellular proteins and nucleic acids in patients with PBC suggests that PBC is a multisystem autoimmune disease which is similar to other systemic autoimmune diseases.
Clinical Investigations With Medical Devices
Authors: Robert S. Kennedy
Journal: JAMA (1981)

IN MAY 1976, Congress passed the Medical Device Amendments to the Federal Food, Drug, and Cosmetic Act. These amendments provide the Food and Drug Administration with substantial new authority in the regulation of new and existing medical devices. The term "medical device" includes all of the items readily identified as devices as well as in vitro diagnostic devices used in the clinical laboratory and some products previously regulated by the FDA's Bureau of Drugs, such as soft contact lenses and intrauterine devices, or by the Bureau of Biologics, such as some arterial grafts. The Medical Device Amendments included provisions designed to avoid the overregulation of certain devices. For instance, all medical devices are classified into one of three regulatory classes so that the amount of regulation for a device is proportional to the product's potential hazards. Class I devices are subject only to the general controls applicable to all devices,
Asthma and contact urticaria caused by rice in a housewife
Authors: A. Lezaun, J. M. Igea, S. Quirce, M. Cuevas, F. Parra, M. D. Alonso, J. A. Martín, M. S. Cano
Journal: Allergy (1994)

We report the case of an atopic housewife who presented with rhinoconjunctivitis‐asthma and contact urticaria from handling rice and other cereals. She tolerated cooked cereals. Both skin prick tests with a rice extract (20% w/v) and a rub test with raw rice gave positive results. Bronchial challenge test with methacholine revealed a PC 20 of 0.45 mg/ml. The challenge test with raw rice resulted in immediate and late clinical and spirometric responses; pretreatment with DSCG inhibited both responses. The histamine release test (HRT) with rice was positive, and we detected rice‐specific IgE antibodies by REIA in the patient's serum. Skin prick tests, HRT, and RAST with a battery of cereals gave positive results. Finally, the rice REIA was inhibited by rice (75%), rye (63%), corn (64%), and wheat (51%) extracts.
Patient Delay in Cancer
Authors: Thomas P. Hackett, N. H. Cassem, John W. Raker
Journal: New England Journal of Medicine (1973)

Abstract Analysis was made of psychosocial factors influencing the amount of elapsed time between the first sign or symptom of cancer and the search for medical help in 563 patients. Delay remained much the same as that reported in similar surveys conducted at the same hospital 30 and 50 years earlier. Detection of cancer through routine physical examination ensured the least delay. Worry about the condition reduced delay time more than pain, incapacity or other factors. Patients of higher social class sought help significantly sooner than the less privileged. Those who openly referred to their condition as cancer had significantly less delay than those who used the term, "tumor," or some other euphemism. Delay in seeking medical help appeared to be a conscious and deliberate act rather than a failure to perceive the neoplasm or to comprehend its consequences. (N Engl J Med 289: 14–20, 1973)
Unilateral Pleuritis and Regional Lung Function
Authors: FRANK F. DAVIDSON
Journal: Annals of Internal Medicine (1972)

The effects of unilateral pleuritis on the distribution of pulmonary blood flow and ventilation and on alveolar expansion, in both the involved and normal-appearing lung, were measured with radioactive xenon-133. Total blood flow and ventilation were reduced to the lung with pleural disease, but ventilation was decreased more than perfusion. The decrease in perfusion to the lung with pleural disease was more marked at lower lung volumes. Blood flow and ventilation were redistributed away from the lung base in the lung with pleural disease, and blood flow was also shifted away from the lung base in the contralateral lung. With a maximum inspiration from residual volume to total lung capacity, alveolar expansion was decreased, compared with that in normal lungs, both in the lung with pleural disease and in the contralateral lung. Unilateral pleuritis thus appears to affect the mechanical function of both lungs.
Acute compartment syndromes resulting from anticoagulant treatment.
Authors: S. M. Hay, M. J. Allen, M. R. Barnes
Journal: BMJ (1992)

and clinicoserological evaluation.Mean ages of donors and partners were: group 1, 52-6 and 51 9 years; group 2, 48-0 and 47 4 years; and group 3, 46 3 and 46-8 years.All serum samples tested for alanine aminotransferase activity, hepatitis B surface antigen, and anti-HIV were screened with Abbott hepatitis C virus enzyme immunoassay, second generation kit.In group 1, 10 partners (six men) tested anti-HCV positive, and in group 2 three partners (two men) tested positive.Among the partners of controls one woman tested anti-HCV positive (table).(This last result (1 -5%) is Prevalence of anti-HCVpositive subjects in groups 1-4* 1 la lb 2 3 4 No anti-HC%V negative 33 22 11 40 67 23 No (O/0) anti-HCV positive 10 (23 3) 7 (24 1) 3 (21 4) 3 (7 0) 1 (1 5) 0 Total 43 29 14 43 68 23 X Test (three degrees of freedom) 19 8; p < 00005.*Group 1: heterosexual partners of anti-HCV positive blood donors with chronic liver disease (subset la) or previously abnormal alanine aminotransferase activities (subset lb); group 2: heterosexual partners of anti-HCV positive donors without previously known abnormal alanine aminotransferase activities; group 3: controls (heterosexual partners of random anti-HCV negative donors); group 4: children or other family members of anti-HCV positive subjects.consistent with findings in Piedmont among people of the same age range.Serum samples from the 14 partners positive for anti-HCV were tested with a recombinant immunoblot assay (Ortho) capable of detecting antibodies to antigens 5-1-1, c-100-3, c22-3, and c33c.All gave positive results with at least two antigens.Identical antigenic specificities were observed in seven of the 13 couples in whom both partners were anti-HCV positive.Among 23 children or other family members of anti-HCV positive subjects (group 4; mean age 14-3 years) none (15 in group 1 families, eight in group 2) tested positive (table).
Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model
Authors: Jian Guan, Weimin Tong, Wenyong Ding, Shiwei Du, Zhifeng Xiao, Qianqian Han, Zhaohui Zhu, Xinjie Bao, Ximin Shi, Chenxi Wu, Jiani Cao, Yi Yang, Wenbin Ma, Guilin Li, Yong Yao, Jun Gao, Junji Wei, Jianwu Dai, Renzhi Wang
Journal: Biomaterials (2011)