tbuckley/cabot-search huggingface dataset:
Points: Human papillomavirus infection of the uterine cervix of women without cytological signs of neoplasia
Authors: M. Byrne, D Taylor-Robinson, J R W Harris
Journal: BMJ (1987)

in addition to Doppler studies.If they judged, again exclusively by their interpretation of the femoral pulse, that there was some aortoiliac disease then blind aortoiliac surgery was advocated in addition to the distal surgery.If angiography showed a localised iliac stenosis we would proceed to angioplasty.This procedure alone might improve the patient's clinical condition or it might subsequently be necessary to proceed to bypass surgery or further angioplasty.Whereas we advocate and use extensively Doppler ultrasound in the management of peripheral vascular disease, we see it as a critical adjunct to angiography in the combined treatment of patients with peripheral vascular disease by both the surgeon and the radio- logist.1
Digital Superimposition of CT and Positive SPECT Tumor Images Phantom Study and Clinical Applications
Authors: FRANçOISE MONTRAVERS, MARCEL RICARD, JEAN LUMBROSO, MIREILLE DI PAOLA, MARTIN SCHLUMBERGER, CLAUDE PARMENTIER, ROBERT DI PAOLA
Journal: Clinical Nuclear Medicine (1997)

Digital superimposition of SPECT and CT data was evaluated in a phantom and then applied to patient data. Seven patients were studied. Six patients had pheochromocytomas as evidenced by I-131 or I-123 MIBG localization and one had ovarian cancer imaged by In-111 OC125 MoAb. Anatomic or skin landmarks identified the level of each SPECT transaxial slice. Both SPECT and CT image data sets were transferred to a minicomputer connected to an image processor. Afterwards, a scaled, rotated, and translated realignment was performed. Data for each modality were coded in different primary colors and then superimposed. Superimposition of phantom data was checked for the absence of distortion of pinpoint and large structures. For suspected tumor sites, superimposition of the patients' slices were allowed to check for matching SPECT and CT abnormalities to localize a SPECT abnormality without a corresponding CT lesion or to distinguish SPECT abnormalities from those seen on CT. In one case, the technique failed because of very low I-131 MIBG-tumor uptake. The superimposition decreases false positives in SPECT and both false negatives or false positives in CT.
Early detection of progressive renal dysfunction in patients with coronary artery disease
Authors: Giorgio Fuiano, Domenico Mancuso, Ciro Indolfi, Annalisa Mongiardo, Massimo Sabbatini, Giuseppe Conte, Luca De Nicola, Roberto Minutolo, Giuseppe Mazza, Paola Cianfrone, Michele Andreucci
Journal: Kidney International (2005)
Loss of HBsAg after interferon-α treatment: Cure of chronic hepatitis B virus?
Authors: Gary L. Davis
Journal: Hepatology (1991)

Sixty-four patients with chronic hepatitis B who were treated with interferon-α (recombinant IFN-α-2a in 9 patients, recombinant IFN-α-2b in 50 patients and lymphoblastoid IFN-α-n1 in 5 patients) in protocols conducted at the Liver Diseases Section of the National Institutes of Health between 1984 and 1986 were observed with sequential determinations of serum ALT levels, HBsAg and serological markers of hepatitis B virus replication (HBeAg, hepatitis B virus DNA polymerase, hepatitis B virus DNA by blot hybridization and hepatitis B virus DNA by polymerase chain reaction). Among the 64 treated patients, 23 responded to interferon treatment with loss of HBeAg and improvement in serum ALT. Three patients (13%) relapsed, all within the first year of follow-up. The remaining 20 patients continued to have no detectable HBeAg or hepatitis B virus DNA (dot blot) in serum during follow-up of 3 to 7 yr (mean = 4.3 yr), although 3 patients had minimal elevations of serum ALT. Thirteen patients (65%) lost HBsAg between 0.2 and 6 yr (mean = 3 yr) after loss of HBeAg. Although none of the 20 patients had detectable serum hepatitis B virus DNA (dot blot), all 7 patients with persistent HBsAg had detectable serum hepatitis B virus DNA by the polymerase chain reaction. Sequential testing in HBsAg-patients indicated the serum hepatitis B virus DNA usually became undetectable by the polymerase chain reaction at about the time of loss of HBsAg. Only 2 of 13 HBsAg- patients had hepatitis B virus DNA detectable in serum by the polymerase chain reaction.
Abstract 3307: Angiomotin regulates the Hippo pathway to increase prostate cancer cell growth
Authors: Angelica Ortiz, Hao Zeng, Sue-Hwa Lin
Journal: Cancer Research (2014)

Abstract Angiomotin (AMOT) is a member of the motin family that consists of three members, AMOT, AMOTL1, and AMOTL2, which function as either positive or negative regulators of cell growth depending on interacting proteins and cellular context. The role of AMOT in prostate cancer (PCa) has not been studied. AMOT is expressed as two isoforms, AMOTp80 and AMOTp130. The AMOTp130 isoform has an extended 409 aa N-terminal domain that is absent in AMOTp80. Both AMOTp80 and AMOTp130 are expressed in LNCaP and C4-2B4, but at a very low level in PC3-mm2 PCa cells. We found that expression of AMOTp130 and AMOTp80 have distinct functions in PCa cells. While AMOTp80 functions as a tumor promoter by enhancing PCa cell proliferation, AMOTp130 did not. We further show that AMOTp80 affects the Hippo tumor suppressor pathway by inhibiting LATS1 and YAP phosphorylation, resulting in nuclear translocation of YAP. Once in the nucleus, YAP increases transcription of the target protein BMP4. Moreover, inhibition of BMP receptor activity by LDN-193189 abrogates AMOTp80-mediated proliferation. These observations suggest that AMOTp80 induces the expression of BMP4, which functions in an autocrine manner to promote PCa cell proliferation. Together, our studies identify AMOTp80-MST-LATS1-YAP-BMP4 as a novel signal pathway that regulates PCa cell proliferation. Citation Format: Angelica Ortiz, Hao Zeng, Sue-Hwa Lin. Angiomotin regulates the Hippo pathway to increase prostate cancer cell growth. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3307. doi:10.1158/1538-7445.AM2014-3307
An Address ON THE MEDICAL ASPECTS OF CARCINOMA OF THE BREAST
Authors: W. Osler
Journal: BMJ (1906)

HE physician sees carcinoma of the breast at two periods.Hoping against hope, and dreading the knife, women consult him, rather than the " surgeon,.about a lump" wichi thley hiave noticed.But far more important are the numerous and unhappy victims of the late internal metastases.Having for some years been much interested subject lected notes of cases, one ~series of which I have already published.'The cases may be considered under two divisions.I. THE CONDITION OF THE BREAST ITSELF.Apart from definite tumour or cyst, the consulting physician does not often see patients with trouble in the breast.Sometimes, indeed, he overlooks the true nature -of a case by omitting the examination of the breast, for- .gettingthat extensive general lesions may be associated with a small latent carcinoma.Such an instance I have reported (in the paper referred to).A woman, aged 29, -was admitted with enlargement of the right cervical and ;axillary glands and a pleural effusion on the same side.Naturally enough the condition was supposed to be tuber- .culous.She made no complaint of tile breast, nor was it -examined.The true nature of the trouble was only dis- -covered post mortem, when there was found in the breast -on the same side a carcinoma not much larger than a -walnut.The importance of the character of the examination is well illustrated in Case vii of my first series; a large, powerfully-built man had suffered for some months with .symptoms of disease of the spinal cord, and becoming -paraplegic on his way home from Florida was admitted to the Johns Hopkins Hospital.When stripped for ex- .amination,as I looked at him from the foot of the bed, -my attention was at once attracted to the greater prominence of the right breast.He had not noticed it himself, nor had his physician.It was the seat of a quite large -carcinoma, and his remarkable spinal cord symptoms were due to metastases.Mastitis Carcinomatosa.An important local condition leading to error in diagnosis is a diffuse inflammatory infiltration of the breast, extending rapidly beyond its limits, and even * Delivered before the Leamington Medical Society.5
Molecular Signature of MT1-MMP: Transactivation of the Downstream Universal Gene Network in Cancer
Authors: Dmitri V. Rozanov, Alexei Y. Savinov, Roy Williams, Kang Liu, Vladislav S. Golubkov, Stan Krajewski, Alex Y. Strongin
Journal: Cancer Research (2008)

Abstract Invasion-promoting MT1-MMP is directly linked to tumorigenesis and metastasis. Our studies led us to identify those genes, the expression of which is universally linked to MT1-MMP in multiple tumor types. Genome-wide expression profiling of MT1-MMP–overexpressing versus MT1-MMP–silenced cancer cells and a further data mining analysis of the preexisting expression database of 190 human tumors of 14 cancer types led us to identify 11 genes, the expression of which correlated firmly and universally with that of MT1-MMP (P &amp;lt; 0.00001). These genes included regulators of energy metabolism (NNT), trafficking and membrane fusion (SLCO2A1 and ANXA7), signaling and transcription (NR3C1, JAG1, PI3Kδ, and CK2α), chromatin rearrangement (SMARCA1), cell division (STK38/NDR1), apoptosis (DAPK1), and mRNA splicing (SNRPB2). Our subsequent extensive analysis of cultured cells, tumor xenografts, and cancer patient biopsies supported our data mining. Our results suggest that transcriptional reprogramming of the specific downstream genes, which themselves are associated with tumorigenesis, represents a distinctive “molecular signature” of the proteolytically active MT1-MMP. We suggest that the transactivation activity of MT1-MMP contributes to the promigratory cell phenotype, which is induced by this tumorigenic proteinase. The activated downstream gene network then begins functioning in unison with MT1-MMP to rework the signaling, transport, cell division, energy metabolism, and other critical cell functions and to commit the cell to migration, invasion, and, consequently, tumorigenesis. [Cancer Res 2008;68(11):4086–96]
Protein‐bound cobalamin absorption declines in the elderly
Authors: John D. Scarlett, Helen Read, Kerin O'Dea
Journal: American Journal of Hematology (1992)

Abstract A modified protein‐bound cobalamin absorption test was used to study dietary cobalamin absorption in healthy adults of different age groups and patients with isolated low serum concentrations of cobalamin. Dietary cobalamin absorption was significantly reduced in healthy adults aged 55‐75 years compared with young adults, with a further reduction in those older than 75 years. No difference was detected between dietary cobalamin absorption in patients with isolated low serum cobalamin and controls of a similar age group. Cobalamin malabsorption was associated with elevated serum gastrin. The diagnostic value of this protein‐bound cobalamin absorption test in the elderly was limited by the frequent finding of reduced absorption in healthy elderly people with normal serum cobalamin concentrations. The performance of such tests should be evaluated in different age groups before application in diagnosis.
Comparative study between doxorubicin-eluting beads and conventional transarterial chemoembolization for treatment of hepatocellular carcinoma
Authors: Myeong Jun Song, Ho Jong Chun, Do Seon Song, Hee Yeon Kim, Sun Hong Yoo, Chung-Hwa Park, Si Hyun Bae, Jong Young Choi, U Im Chang, Jin Mo Yang, Hae Giu Lee, Seung Kew Yoon
Journal: Journal of Hepatology (2012)
Medical Education — Trends and Adjustments in the University and Its Teaching Hospital
Authors: Samuel Proger
Journal: New England Journal of Medicine (1965)

CHANGES in medical education are often little more than inevitable responses to altered circumstances. At other times the changes are designed to initiate new trends, to facilitate developing trends or to check undesirable tendencies. The following consideration of preclinical and clinical teaching concerns itself in the preclinical area with trends that are considered inevitable because of expanding knowledge, and in the clinical area with tendencies that are thought in some respects to be undesirable because of the imbalance that they are creating. The large and extremely important problems related to the continuing education of the physician in practice are beyond . . .
HMG-CoA Reductase Inhibitors and the Risk of Hip Fractures in Elderly Patients
Authors: Philip S. Wang
Journal: JAMA (2000)

ContextRecent animal studies have found that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) lipid-lowering drugs (statins) substantially increase bone formation, but whether statin use in humans results in clinically meaningful bone formation or a reduction in the risk of osteoporotic fractures is not known.ObjectiveTo determine whether the use of statins is associated with reduced hip fracture risk.DesignCase-control study.Setting and PatientsA total of 6110 New Jersey residents aged 65 years or older and enrolled in Medicare and either Medicaid or the Pharmacy Assistance for the Aged and Disabled program. Case patients (n=1222) underwent surgical repair of a hip fracture in 1994. Control patients (n=4888) were identified at a ratio of 4:1 and frequency-matched to case patients for age and sex.Main Outcome MeasureAdjusted odds ratio (OR) of hip fracture by statin use in the 180 days and 3 years prior to the index date (the earliest date of admission for surgery), adjusted for demographic and clinical characteristics and health care utilization.ResultsUse of statins in either the prior 180 days (adjusted OR, 0.50; 95% confidence interval [CI], 0.33-0.76) or prior 3 years (adjusted OR, 0.57; 95% CI, 0.40-0.82) was associated with a significant reduction in the risk of hip fracture, even after controlling for variables such as race, insurance status, psychoactive medications, estrogen and thiazide use, ischemic heart disease, cancer, and diabetes mellitus. No significant relationship was observed between use of nonstatin lipid-lowering agents and hip fracture risk. Clear relationships were observed between the degree of reduction in hip fracture risk and the extent of statin use; there was no evidence of such relationships with nonstatin lipid-lowering agents. After adjusting for extent of statin use in the prior 3 years, current use (on the index date) was associated with a 71% reduction in risk (adjusted OR, 0.29; 95% CI, 0.10-0.81). The relationship between statin use and hip fracture risk persisted after controlling for variables such as the number of medications, the Charlson comorbidity index score, and hospitalization or nursing home stay in the last 180 days, as well as after excluding patients who were in a nursing home prior to their index date or who died in the year after their index date. Use of nonstatin lipid-lowering agents was not observed to be associated with reduction in hip fracture risk in any of these alternative models or analyses.ConclusionsThese findings support an association between statin use by elderly patients and reduction in the risk of hip fracture. Controlled trials are needed to exclude the possibility of unmeasured confounders.
On Growing Old
Authors: Myrtle Lundberg
Journal: Annals of Internal Medicine (2002)

On Being a Patient19 March 2002On Growing OldMyrtle LundbergMyrtle LundbergDuluth, MN 55805Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-6-200203190-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What happened to that skinny kid—the one so skinny her ribs could be counted just by looking? Today, she is a twittery, purse-clutching, cane-wielding, pill-popping little old lady living alone. Still skinny, she prefers the term petite. It sounds better.I am that skinny kid. I'm missing a few parts and have replaced several of the worn-out ones. Then, there are all the abuses suffered by this 88-year-old body. Nothing prepares you for old age. You get out of bed one morning and voila! A bolt out of the blue and you can no longer function normally. What to do? ... Author, Article, and Disclosure InformationAffiliations: Duluth, MN 55805Corresponding Author: Robert J. Sjoberg, MD, Endocrinology Associates, A St. Luke's Specialty Clinic, 1000 East First Street, Suite 203, Duluth, MN 55805; email, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLife on the Receiving End: A Qualitative Analysis of Health Providers??? Illness Narratives 19 March 2002Volume 136, Issue 6Page: 484-485KeywordsArthritisKneesPacemakersRibsScarsStomachThyroidTotal hip replacementUlcersWheelchairs ePublished: 19 March 2002 Issue Published: 19 March 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effectiveness of pergolide mesylate in long term treatment of hyperprolactinaemia.
Authors: S Franks, P M Horrocks, S S Lynch, W R Butt, D R London
Journal: BMJ (1983)

Twenty five patients with hyperprolactinaemia were treated with pergolide mesylate, a new dopamine receptor agonist. Twenty three received treatment for six to 20 months, and in all serum prolactin concentrations were considerably reduced. In most patients prolactin concentrations were maintained in the normal range by a low, once daily dose of pergolide and reversal of associated reproductive disorders was observed. Tumour volume as assessed by computed tomography decreased considerably during treatment in three out of four patients with a pituitary tumour. The drug was well tolerated. Side effects were similar to those of bromocriptine, but four out of eight patients who had been forced to stop taking bromocriptine because of untoward effects were subsequently able to tolerate treatment with pergolide. Pergolide mesylate promises to be a useful addition to the currently available long acting dopamine agonists in the management of hyperprolactinaemia.
Dangerous people with severe personality disorder
Authors: P. E Mullen
Journal: BMJ (1999)

This summer the British Department of Health and the Home Office jointly issued a paper on Managing Dangerous People with Severe Personality Disorder. 1 The paper was apparently “based on the results of extensive informal discussions” and sets out the government's policy objectives in dealing with what the paper calls the “dangerous severely personality disordered.” The paper avoids descending into the apparently unending debate over what is, or is not, a personality disorder and to what extent personality disorders are treatable and attempts to cut through the gordian knot with what presumably are intended as straightforward and practical proposals for action. If only it were that simple.

This government “framework for the future” proposes legal powers for detaining indefinitely people with dangerous severe personality disorder. Specialists, including psychiatrists, are to be employed both to better identify people with dangerous severe personality disorder and to develop “approaches to detention and management.” Finally a comprehensive programme of research is to be established to support development of policy and practice. The proposals make a point of insisting that “indeterminate detention will be authorised only on the basis of evidence from an intensive specialist assessment” …
Teaching Health Workers Malaria Diagnosis
Authors: Graham Icke, Richard Davis, William McConnell
Journal: PLoS Medicine (2005)

Malaria kills over one million people in Africa each year and contributes 10% of the continent's burden of disease [1]. One of the factors that affects the morbidity and mortality rate is incorrect diagnosis [2]. In this article, we describe a freely available online training tool for health professionals to learn malaria diagnosis. We describe why we launched it and discuss how it is being used.
Contributions to Sports Medicine Journals
Authors: John P. Jesse
Journal: British Journal of Sports Medicine (1976)

The Am. College of Sports medicine journal is dominated by the exercise physiologists and physical education research specialists,2) The Physician and Sports medicine by medical practioners and orthopedic specialists, 3) The journal of sports medicine by the orthopedic profession, and 4) The athletic journals by the coaches.However their comments do not apply to your journal or association.I wonder how often
Court of Protection is asked to impose sterilisation on woman with learning disabilities
Authors: C. Dyer
Journal: BMJ (2011)

A court decision on whether to impose a forced sterilisation on a 21 year old woman with learning disabilities has been postponed while the judge gathers more evidence on her best interests and her mental capacity to take decisions about contraception.

Named only as P, she was due to deliver her second child by caesarean section on 16 February, the day after the case went to court. Her mother, Mrs P, broke down in tears as she asked Mr Justice …
Changing clinical expression of <scp>B</scp> ehçet disease in <scp>K</scp> orea during three decades (1983–2012): chronological analysis of 3674 hospital‐based patients
Authors: D.Y. Kim, M.J. Choi, S. Cho, D.W. Kim, D. Bang
Journal: British Journal of Dermatology (2013)

Background Behçet disease (BD) is a chronic multisystemic vasculitis affecting blood vessels of any calibre or type. Recent evidence suggests that the clinical expression of BD is lessening. Objectives To examine the clinical expression of BD in Korea during the past three decades via a large patient registry. Methods Initial manifestations of patients with BD seen at a tertiary referral hospital between 1983 and 2012 were reviewed retrospectively, stratifying patients by decade to compare epidemiological data and cardinal symptoms. Results In total 3674 patients with BD were reviewed. Significant proportional declines occurred with respect to male sex, complete type BD and major presenting features (genital ulcers, ocular involvement and skin lesions), whereas the mean patient age rose progressively, as did the frequencies of joint, gastrointestinal and central nervous system manifestations (all P < 0·0001). Conclusions During the past three decades, clinical expression of BD in Korea has changed, resulting in fewer instances of complete type disease, declining male propensity, and shifting patterns of organ involvement.
ON THE RELATION BETWEEN THE VARIETY OF MICRO-ORGANISMS AND THE COMPOSITION OF STONE IN CALCULOUS PYELONEPHRITIS.
Authors: THOMAS R. BROWN
Journal: JAMA (1901)

No subject in renal diseases has been more discussed than calculus, especially as regards the etiologic factors involved in the production of the stone. Many theories have been held regarding the origin of stone in nephrolithiasis, but of these most have been finally abandoned from insufficient evidence; thus the idea that telluric conditions play an important rôle in this connection has been practically abandoned by all, as also the belief that gout was the most important etiologic factor in the development of such a condition, while Senator, Von Noorden and numerous other observers have definitely shown that the method of living and the variety of diet play, speaking generally, but a small part. Our ideas regarding the formation of uric acid in the body have undergone a marked change, through the work of Horbaczewski and Kossel, who showed that in a large number of cases, at least, the uric acid