Renin-Secreting Adenocarcinoma of the Colon
Authors: Tim R. Ringrose, Paddy A. Phillips, George B.M. Lindop
Journal: Annals of Internal Medicine (1999)

Letters16 November 1999Renin-Secreting Adenocarcinoma of the ColonTim R. Ringrose, Paddy A. Phillips, and George B.M. LindopTim R. RingroseThe John Radcliffe Hospital; Headington, Oxford OX3 9DU, United Kingdom (Ringrose)The John Radcliffe Hospital; Headington, Oxford OX3 9DU, United Kingdom (Phillips)Western Infirmary; Glasgow G11 6NT, United Kingdom (Lindop)Search for more papers by this author, Paddy A. PhillipsThe John Radcliffe Hospital; Headington, Oxford OX3 9DU, United Kingdom (Ringrose)The John Radcliffe Hospital; Headington, Oxford OX3 9DU, United Kingdom (Phillips)Western Infirmary; Glasgow G11 6NT, United Kingdom (Lindop)Search for more papers by this author, and George B.M. LindopThe John Radcliffe Hospital; Headington, Oxford OX3 9DU, United Kingdom (Ringrose)The John Radcliffe Hospital; Headington, Oxford OX3 9DU, United Kingdom (Phillips)Western Infirmary; Glasgow G11 6NT, United Kingdom (Lindop)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-10-199911160-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We describe what we believe to be the first case of a renin-secreting adenocarcinoma of the colon. A 66-year-old retired schoolteacher presented with a 3-month history of headaches, vomiting, constipation, and weight loss. She had severe hypertension (blood pressure, 210/140 mm Hg) and hypokalemia (potassium level, 2.2 mmol/L). A barium enema showed appearances of cecal carcinoma. Both plasma renin levels (21 pmol/L; normal, 1.1 to 2.7 pmol/L) and plasma aldosterone levels (1010 pmol/L; normal, 100 to 450 pmol/L) were elevated. Potassium supplements and oral spironolactone (100 mg daily) rapidly corrected the hypokalemia, and a calcium antagonist (amlodipine, ...References1. Genest J, Rojo-Ortega JM, Kuchel O, Boucher R, Nowaczynski W, Lefebvre R, et al . Malignant hypertension with hypokalemia in a patient with renin-producing pulmonary carcinoma. Trans Assoc Am Phys. 1975;88:192-200. MedlineGoogle Scholar2. Ruddy MC, Atlas SA, Salerno FG. Hypertension associated with a renin-secreting adenocarcinoma of the pancreas. N Engl J Med. 1982;307:993-7. CrossrefMedlineGoogle Scholar3. Lindop GB, Leckie BJ, Mimran A. Renin-secreting tumours. In: Robertson JI, Nicholls MG, eds. The Renin-Angiotensin System. London: Gower Medical Publishing; 1992:54.1-54.13. Google Scholar4. Saito T, Fukamizu A, Okada K, Ishikawa S, Iwamoto Y, Kuzuya T, et al . Ectopic production of renin by ileal carcinoma. Endocrinol Jpn. 1989;36:117-24. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: The John Radcliffe Hospital; Headington, Oxford OX3 9DU, United Kingdom (Ringrose)The John Radcliffe Hospital; Headington, Oxford OX3 9DU, United Kingdom (Phillips)Western Infirmary; Glasgow G11 6NT, United Kingdom (Lindop) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDisorders of Potassium BalanceA patient with a juxtaglomerular cell tumor with histological vascular invasionTumeurs à rénineTumeurs à réninePrimary Reninism or Renin-Secreting Tumors 16 November 1999Volume 131, Issue 10Page: 794-795KeywordsAdenocarcinomaAldosteroneBlood plasmaBlood pressureColonPotassiumSurgeryTriiodothyronineVomitingWeight loss Issue Published: 16 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...