Liver Cancer on the Rise
Authors: Jennifer Fisher Wilson
Journal: Annals of Internal Medicine (2005)

Current Clinical Issues21 June 2005Liver Cancer on the RiseJennifer Fisher WilsonJennifer Fisher WilsonAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-12_Part_1-200506210-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Liver cancer is one of the world's most common types of cancer, and one of the most deadly. Worldwide prevalence is highest in southeast Asia and sub-Saharan Africa, but it has recently struck Japan particularly hard. The number of deaths from liver cancer in Japan increased steadily from about 10,000 in 1975 to 35,000 in 2002 because of an epidemic of hepatocellular carcinoma (HCC). This disorder, which accounts for 80% to 90% of all cases of liver cancer, is now the third most common cause of cancer death among Japanese men and the fifth most common cause among Japanese women.... References1. Kojiro M. Focus on dysplastic nodules and early hepatocellular carcinoma: an Eastern point of view. Liver Transpl. 2004;10 2 Suppl 1 S3-8. [PMID: 14762831] CrossrefMedlineGoogle Scholar2. Di Bisceglie AM. Issues in screening and surveillance for hepatocellular carcinoma. Gastroenterology. 2004;127 5 Suppl 1 S104-7. [PMID: 15508072] CrossrefMedlineGoogle Scholar3. Adams PC, Arthur MJ, Boyer TD, DeLeve LD, DiBisceglie AM, Hall M, et al. Screening in liver disease: report of an AASLD clinical workshop. Hepatology. 2004;39:1204-12. [PMID: 15122748] CrossrefMedlineGoogle Scholar4. Ikai I, Itai Y, Okita K, Omata M, Kojiro M, Kobayashi K, et al. Report of the 15th follow-up survey of primary liver cancer. Hepatol Res. 2004;28:21-9. [PMID: 14734147] CrossrefMedlineGoogle Scholar5. Lencioni R, Cioni D, Crocetti L, Franchini C, Pina CD, Lera J, et al. Early-stage hepatocellular carcinoma in patients with cirrhosis: long-term results of percutaneous image-guided radiofrequency ablation. Radiology. 2005;234:961-7. [PMID: 15665226] CrossrefMedlineGoogle Scholar6. Shiratori Y, Shiina S, Teratani T, Imamura M, Obi S, Sato S, et al. Interferon therapy after tumor ablation improves prognosis in patients with hepatocellular carcinoma associated with hepatitis C virus. Ann Intern Med. 2003;138:299-306. [PMID: 12585827] LinkGoogle Scholar7. Nishiguchi S, Kuroki T, Nakatani S, Morimoto H, Takeda T, Nakajima S, et al. Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet. 1995;346:1051-5. [PMID: 7564784] CrossrefMedlineGoogle Scholar8. Morgan TR, Mandayam S, Jamal MM. Alcohol and hepatocellular carcinoma. Gastroenterology. 2004;127 5 Suppl 1 S87-96. [PMID: 15508108] CrossrefMedlineGoogle Scholar9. Caldwell SH, Crespo DM, Kang HS, Al-Osaimi AM. Obesity and hepatocellular carcinoma. Gastroenterology. 2004;127 5 Suppl 1 S97-103. [PMID: 15508109] CrossrefMedlineGoogle Scholar10. El-Serag HB. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology. 2004;127 5 Suppl 1 S27-34. [PMID: 15508094] CrossrefMedlineGoogle Scholar11. Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut. 2005;54:533-9. [PMID: 15753540] CrossrefMedlineGoogle Scholar12. El-Serag HB, Tran T, Everhart JE. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology. 2004;126:460-8. [PMID: 14762783] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Disclosures: None disclosed.E-mail:[email protected]org PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEmerging signals regulating liver tumor initiating cellsTransforming growth factor‑β1 and lysophosphatidic acid activate integrin β6 gene promoter in Hep‑3B cellsMiR-216b is involved in pathogenesis and progression of hepatocellular carcinoma through HBx-miR-216b-IGF2BP2 signaling pathwaySC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activationHispidulin Induces Apoptosis Through Mitochondrial Dysfunction and Inhibition of P13k/Akt Signalling Pathway in HepG2 Cancer CellsThe Inflammation and Liver CancerDevelopments in near-infrared-guided hepatobiliary, pancreatic and other upper gastrointestinal surgeryPotential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinomaExpression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell linesEvaluation of a Modified Enzyme Linked Immunosorbent Assay for Serum PIVKA-II MeasurementCelecoxib Inhibits Interleukin-6/Interleukin-6 Receptor–Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma CellsXZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cellsSynergistic cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and Rana catesbeiana ribonuclease-6 in hepatoma cellsBlocking the IL-6–STAT3 signaling pathway: potential liver cancer therapyHuman vascular adhesion proteın-1 (VAP-1): Serum levels for hepatocellular carcinoma in non-alcoholic and alcoholic fatty liver diseaseExtended O 6 -Methylguanine Methyltransferase Promoter Hypermethylation Following n -Butylidenephthalide Combined with 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) on Inhibition of Human Hepatocellular Carcinoma Cell GrowthA proteomic strategy to identify novel serum biomarkers for liver cirrhosis and hepatocellular cancer in individuals with fatty liver diseaseImage-guided thermochemical ablation: Theoretical and practical considerationsHepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis and therapeuticsHepatocellular carcinoma: Epidemiological profile from a cohort of federal employees in MexicoCucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitroAFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver diseaseHeparin-degrading sulfatases in hepatocellular carcinoma: roles in pathogenesis and therapy targetsDiagnosis of liver cirrhosis by transit-time analysis at contrast-enhanced ultrasonographyProteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acidIonic Versus Nonionic Contrast Media Solvents Used with an Epirubicin-based Agent for Transarterial Chemoembolization of Hepatocellular CarcinomaUltrasound simulation of real-time temperature estimation during radiofrequency ablation using finite element modelsDevelopment of evidence-based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in JapanUsefulness of cancer-testis antigens as biomarkers for the diagnosis and treatment of hepatocellular carcinomaThe NS5A protein of hepatitis C virus represses gene expression of hRPB10α, a common subunit of host RNA polymerases, through interferon regulatory factor-1 binding siteContrast-enhanced ultrasound to evaluate the severity of chronic hepatitis CUltraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and CarcinomasNon-invasive ultrasound-based temperature imaging for monitoring radiofrequency heating—phantom resultsDeactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, AtiprimodCytotoxic effect induced by retinoic acid loaded into galactosyl-sphingosine containing liposomes on human hepatoma cell linesComparison of 11 C-acetate positron emission tomography and 67 Gallium citrate scintigraphy in patients with hepatocellular carcinomaMethylation of Ras association domain family protein 1, isoform A correlated with proliferation and drug resistance in hepatocellular carcinoma cell line SMMC-7721Aspartyl-asparagyl β hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms1I-3 Ultrasound Simulation of Real-Time Temperature Estimation during Radiofrequency Ablation using Finite Element ModelsP2H-5 Ultrasound-Based Temperature Imaging for Monitoring Electromagnetic Radiofrequency Ablation - Phantom Results 21 June 2005Volume 142, Issue 12_Part_1Page: 1029-1032KeywordsCirrhosisHepatitisLiverLiver diseasesLiver transplantationMagnetic resonance imagingSurgeryTransplantationUltrasound imaging ePublished: 21 June 2005 Issue Published: 21 June 2005 CopyrightCopyright © 2005 by American College of Physicians. 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