tbuckley/cabot-search huggingface dataset:
EPIDEMIC CEREBRO-SPINAL MENINGITIS
Authors: J. C. G. Ledingham
Journal: BMJ (1915)

Tlhe ground at Gailes has been ulsedl yearly for over two decades for camiip purposes ; refuse pits lhatve been opened.and covered over; mulch traffic, horse an1d otberwise,-has occurred in the-vicinity of the dr.ainis, and indiscriminate use of sand meant the use of polluted miiaterial.A bac- teriological report on tlle sand in qucstioni an-d vahiable suaggestions miade by the bacteriologist arc appendecl.-BSACTERIOLOaICAL EXAMINATION OF SAND.Sample 1 wa'Ds collected from a small lheap wllichl hiadl becn used for cleansing fooLd utensils andl wliicll presented a soiledl appearance.It was examiined same (lay to dleterminie the nature and amount of bacteria!contamination, if any.Sample 2 was collected fromL foutndation pit for comparison with Samnple 1. SaOzd I. Bacterial Content : 2,060,000 per gram in gelatine at roonm temperature; 95,200 per gram on agar at 37C C. C'olon Grlong (Lactose-F Indol+).-Details:B. coli ... -... Present in 0 01 grami. 1.. neapolitaniis ... Present in 0.01 gram, absent in 0.05 gram.B. coscoroba .. Present in 0.05 gram.?. ntei(di lactici ... Present in 0.001 gram.B. p)rot?es ... Present in 0.CO1 gram.SaMd I1.Bacterial Contwet: 2-1,200 per gram in gelatinie at room temperatture; overgrown witlh colonies of mould (mucus).Colon GCr}outp (Lactose+ Indol+).-Absent in 1 gram.Details: B. coscoroba ... Present in 0.01 gram.
P1-142: A preliminary comparison between short and long survivors consecutively diagnosed in a large hospital included in the regional population-based mesothelioma registry (Liguria, Italy)
Authors: Manlio Mencoboni, Fabio Montanaro, Monica Bianchelli, Simona Tredici, Valentina Galbusera, Omar Racchi, Bruno Faravelli, Giuseppe Pastorino, Andrea Lazzarotto, Valerio Gennaro
Journal: Journal of Thoracic Oncology (2007)
The disabled living centre: what does it do?
Authors: M. A. Chamberlain, J. Gallop
Journal: BMJ (1988)

Seventy five consecutive users of the Leeds disabled living foundation were surveyed. Two thirds of these users were at least moderately severely disabled. Forty eight of the 65 people (74%) who completed the questionnaire were recommended aids, and 33 had received some at the end of the survey. Only 10 of 28 people had received recommended adaptations. Few referrals were made to the centre by doctors. It is important that they tell their patients of this useful service.
A Time to Decide
Authors: Denise A. Niemira
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corticosteroid Use and Peptic Ulcer Disease: Role of Nonsteroidal Anti-inflammatory Drugs
Authors: Joyce M. Piper, Wayne A. Ray, James R. Daugherty, Marie R. Griffin
Journal: Annals of Internal Medicine (1991)

Objective: To estimate the relative risk for peptic ulcer disease that is associated with the use of oral corticosteroids. Design: A nested case-control study. Setting: Tennessee Medicaid program. Participants: The case patients (n = 1415) were hospitalized between 1984 and 1986 for gastric or duodenal ulcer or for upper gastrointestinal hemorrhage of unknown cause. The controls (n = 7063) were randomly selected from Medicaid enrollees not meeting the study criteria for inclusion as case patients. Measurements and Main Results: The estimated relative risk for the development of peptic ulcer disease among current users of oral corticosteroids was 2.0 (95% CI, 1.3 to 3.0). However, the risk was increased only in those who concurrently received nonsteroidal anti-inflammatory drugs (NSAIDs); these persons had an estimated relative risk associated with current corticosteroid use of 4.4 (CI, 2.0 to 9.7). In contrast, the estimated relative risk for those corticosteroid users not receiving NSAIDs was 1.1 (CI, 0.5 to 2.1). Persons concurrently receiving corticosteroids and NSAIDs had a risk for peptic ulcer disease that was 15 times greater than that of nonusers of either drug. Conclusion: Discrepant findings among earlier studies regarding steroids and the risk for peptic ulcer disease could in part be due to differences in the use of NSAIDs among study participants. The high risk for peptic ulcer disease associated with combined use of NSAIDs and corticosteroids indicates the need to prescribe this drug combination cautiously.
Cycling injuries with special reference to events in the 1970 Commonwealth Games in Edinburgh
Authors: J. Dorward
Journal: British Journal of Sports Medicine (1970)

The cyclist puts his energies into a machine, and this machine controls his muscle movements within a quite limited range so that even with all out effort or with the onset of fatigue the muscles are grooved along a controlled path.Consequently, muscle injury specific to cycling is not very significant.The commonest complaints are almost entirely confined to the lumbar region and the knees.
Gastrointestinal Blood Loss-Reply
Authors: Donald H. Loebl
Journal: JAMA (1977)

We find no fault with the conclusions reached by Dr Hanauer and, in fact, fully support his closing statement that "aspirin remains the drug of choice unless clearly not tolerated." However, we feel that Dr Hanauer missed the major point of our paper, namely, that a scientific methodology is available that can be employed in a feasible manner to test the "short-term risk of erosive gastritis" in patients who receive drugs that contribute to this risk. No data were presented on long-term risks of these drugs. As indicated by Dr Hanauer, the true frequency of a major gastrointestinal bleeding episode, in contrast to the smaller amounts of bleeding usually seen in erosive gastritis, remains to be determined by clinical experience. For the short term, we suggest that objective data as illustrated by our report best assess this facet of drug action.
Adolescent Diabetes Management and Mismanagement
Authors: Jill Weissberg-Benchell, Allen M Glasgow, W Douglas Tynan, Philip Wirtz, Jane Turek, Joseph Ward
Journal: Diabetes Care (1995)

To document the existence and prevalence of adolescent-generated diabetes management techniques.One hundred forty-four adolescents completed the confidential questionnaire developed for this study. Glycohemoglobin was also obtained for each individual.Within the 10 days before their clinic visit, many adolescents admitted to engaging in various mismanagement behaviors, with 25% admitting to missing shots. Parents tend to underestimate adolescent mismanagement. Missing shots was significantly related to poor control (P < 0.01). Older adolescents engaged in more mismanagement than their younger cohorts (P < 0.001). The questionnaire factored into two subscales: blatant mismanagement and faking.This study shows the importance of recognizing the prevalence of mismanagement among adolescents.
Diagnostic Procedures and Reagents: Technics for the Laboratory Diagnosis and Control of the Communicable Diseases
Authors: John B. Henry
Journal: JAMA (1964)

The title does not reflect the content of the book. A more descriptive title would be "Laboratory Diagnostic Procedures in Bacteriology, Mycology, Parasitology, and Immunology." The efforts of 148 authorities have yielded a definitive textbook on diagnostic medical microbiology which deserves the highest praise. The first four chapters encompass the basic activities in a diagnostic microbiological service laboratory. These include, among other topics, general procedures, organization, equipment, materials, and laboratory infections. Formulas and preparation of 116 culture media are dealt with in detail. In each of the 28 chapters the most difficult task was the establishment of one selected method representing the best method for each type of examination, as determined by the consensus of individual experts in the various fields. While all authorities might not agree with the choice, at least the reader is not confused by a multiplicity of diagnostic approaches for a specific organism or specimen. Among
Pseudomyxoma of the pleural and peritoneal cavities.
Authors: G Radosavljevic, B Nedeljkovic, V Kacar
Journal: Thorax (1993)

Pseudomyxoma peritonei is a rare clinical manifestation of mucin producing adenocarcinomas. An extensively metastased adenocarcinoma developed a pseudomyxoma that affected not only the peritoneal cavity but also the pleura.
Do intrinsic arterial wall features determine atherosclerosis susceptibility?
Authors: D MOLIN, M POST
Journal: Cardiovascular Research (2006)

Journal Article Do intrinsic arterial wall features determine atherosclerosis susceptibility? Get access Daniel G.M. Molin, Daniel G.M. Molin aDepartment of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Mark J. Post Mark J. Post * aDepartment of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The NetherlandsbDepartment of Biomedical Technology, Eindhoven Institute of Technology, Eindhoven, The Netherlands *Corresponding author. Department of Physiology, Maastricht University, 6229 ER Maastricht, The Netherlands. Tel.: +31 43 3881200; fax: +31 43 3884166. Email address: [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 72, Issue 1, October 2006, Pages 3–4, https://doi.org/10.1016/j.cardiores.2006.07.013 Published: 01 October 2006 Article history Received: 14 July 2006 Accepted: 18 July 2006 Published: 01 October 2006
Mid-dermal elastolysis and pseudoxanthoma elasticum-Iike papillary dermal elastolysis
Authors: A. Rebora, A. Parodi, F. Rongioletti
Journal: British Journal of Dermatology (1995)

Journal Article Mid‐dermal elastolysis and pseudoxanthoma elasticum‐Iike papillary dermal elastolysis Get access A. Rebora, A. Rebora Department of Dermatology, University of Genoa, Viale Benedetto XV, 7‐16132 Genoa, Italy Search for other works by this author on: Oxford Academic Google Scholar A. Parodi, A. Parodi Department of Dermatology, University of Genoa, Viale Benedetto XV, 7‐16132 Genoa, Italy Search for other works by this author on: Oxford Academic Google Scholar F. Rongioletti F. Rongioletti Department of Dermatology, University of Genoa, Viale Benedetto XV, 7‐16132 Genoa, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 3, 1 March 1995, Page 487, https://doi.org/10.1111/j.1365-2133.1995.tb08693.x Published: 01 March 1995
Simple Linear Regression in Medical Research
Authors: Katherine Godfrey
Journal: New England Journal of Medicine (1985)

Abstract This article discusses the method of fitting a straight line to data by linear regression and focuses on examples from 36 Original Articles published in the Journal in 1978 and 1979. Medical authors generally use linear regression to summarize the data (as in 12 of 36 articles in my survey) or to calculate the correlation between two variables (21 of 36 articles). Investigators need to become better acquainted with residual plots, which give insight into how well the fitted line models the data, and with confidence bounds for regression lines. Statistical computing packages enable investigators to use these techniques easily. (N Engl J Med 1985; 313:1629–36.)
Carbohydrate intake and tennis: are there benefits?
Authors: M S Kovacs
Journal: British Journal of Sports Medicine (2006)

Carbohydrate supplementation in prolonged aerobic exercise has been shown to be effective in improving performance and deferring fatigue. However, there is confounding evidence with regard to carbohydrate supplementation and tennis performance, which may be due to the limited number of studies on this topic. This evidence based review, using database searches of Medline and SPORTDiscus, summarises the limited relevant literature to determine if carbohydrate supplementation benefits tennis performance, and, if so, the appropriate amounts and timing. Although more research is required, it appears that it may be beneficial in tennis sessions lasting more than 90 minutes.
Bowel Habit in Thyrotoxicosis and Hypothyroidism
Authors: J. T. Baker, R. F. Harvey
Journal: BMJ (1971)

A prospective study of bowel frequency in patients with thyroid disease showed increased frequency of bowel action in thyrotoxicosis and decreased frequency in myxoedema. The contrary findings of previous studies may be due to the use of inexact criteria in interrogation of the patients.
Connexion of Ovarian and Uterine Disease
Authors: E. J. Tilt
Journal: BMJ (1850)

judgment of the practitioner under whose care it has come.Like many other medicines, Turpentine may fail in producing the effects desired, if all the circumstances which may modify its action be not duly taken into account: but, when judiciously administered, I believe it to be one of the most valuable remedial agents which we possess.
The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase
Authors: Erin G. Rosenbaugh, James W. Roat, Lie Gao, Rui Fang Yang, Devika S. Manickam, Jing Xiang Yin, Harold D. Schultz, Tatiana K. Bronich, Elena V. Batrakova, Alexander V. Kabanov, Irving H. Zucker, Matthew C. Zimmerman
Journal: Biomaterials (2010)
A 3′-Untranslated Region Polymorphism in <i>IGF1</i> Predicts Survival of Non–Small Cell Lung Cancer in a Chinese Population
Authors: Mingfeng Zhang, Zhibin Hu, Jinlin Huang, Yongqian Shu, Juncheng Dai, Guangfu Jin, Rong Tang, Jing Dong, Yijiang Chen, Lin Xu, Xinen Huang, Hongbing Shen
Journal: Clinical Cancer Research (2010)

Abstract Purpose: Disruption of the balance of insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP3) has been implicated in the etiology and progression of lung and other cancers. Single nucleotide polymorphisms (SNP) in IGF1 and IGFBP3 have been reported to be associated with the expression of the IGF-I/IGFBP3 axis. Therefore, we hypothesized that SNPs in these two genes were associated with lung cancer survival. Experimental Design: We selected and genotyped 21 tagging and potentially functional SNPs in IGF1 and IGFBP3 by using Illumina Goldengate Genotyping Chip in a case cohort of 568 patients diagnosed with non–small cell lung cancer (NSCLC) in a Chinese population. Log-rank test and Cox proportional hazard models were used for the survival analyses. Results: We found that rs5742714C/G in the 3′-untranslated region of IGF1 was associated significantly with NSCLC survival after adjustment for demographic and clinicopathologic factors, showing an improved median survival time in patients carrying variant CG/GG genotypes [median survival time, 28.5 months for CG/GG and 23.0 for CC; crude hazard ratio (HR), 0.74; 95% confidence interval (95% CI), 0.57-0.95, and adjusted HR, 0.77; 95% CI, 0.60-0.99]. This protective effect was more predominant for patients receiving surgical operation (HR, 0.58; 95% CI, 0.40-0.85; P for heterogeneity test = 0.045), along with a significant multiplicative interaction between variant genotypes and operation status (P = 0.028). Conclusions: Our findings suggest that rs5742714 in IGF1 may be a genetic modifier for NSCLC prognosis in this Chinese population, especially among patients with surgical operation. Clin Cancer Res; 16(4); 1236–44
A Phase I Trial of Intravenous CG7870, a Replication-Selective, Prostate-Specific Antigen–Targeted Oncolytic Adenovirus, for the Treatment of Hormone-Refractory, Metastatic Prostate Cancer
Authors: Eric J. Small, Michael A. Carducci, James M. Burke, Ron Rodriguez, Lawrence Fong, Lynn van Ummersen, D.C. Yu, Junko Aimi, Dale Ando, Peter Working, David Kirn, George Wilding
Journal: Molecular Therapy (2006)

CG7870 is a replication-selective oncolytic adenovirus genetically engineered to replicate preferentially in prostate tissue. In a previous phase I/II clinical trial of intraprostatic delivery of CG7870 for locally recurrent prostate cancer this virus was well tolerated. In this phase I study CG7870 was administered as a single intravenous infusion in a group-sequential dose escalation design (1 × 1010 to 6 × 1012 viral particles (vp)) to 23 patients with hormone-refractory metastatic prostate cancer. Flulike symptoms (fever, fatigue, rigors, nausea, and/or vomiting) were the most common adverse events. Three therapy-related grade 3 adverse events were reported, one of which (fatigue) was serious. At doses greater than 1012 vp all five patients experienced asymptomatic grade 1 to 2 transaminitis and/or isolated d-dimer elevations starting on day 2 through 8; dose escalation was therefore halted at 6 × 1012 vp. All tested patients had CG7870 genomes present in the peripheral blood for at least 90 minutes after infusion; patients in the highest dose group had persistence of genomes through 29 days. A "secondary" or "delayed" peak in plasma CG7870 genome copies (defined as a >10-fold increase in CG7870 genomes from nadir concentration) suggestive of active viral replication and shedding into the bloodstream was detected in 16/23 (70%) patients. CG7870 was detected in the saliva of 3 patients, whereas all urine samples tested negative. All patients developed antibodies to CG7870. Dose-related increases in interleukins 6 and 10 (IL-6, IL-10) blood levels were detected. The peak IL-6 concentration after CG7870 treatment was associated with a transient, asymptomatic decrease in blood pressure. No partial or complete prostate-specific antigen (PSA) responses were observed; however, 5 patients had a decrease in serum PSA of 25% to 49% following a single treatment, including 3 of 8 patients at the highest dose levels.
Human Antirabies Serum: The Supply Problem
Authors: Joseph J. Kraut
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Geoffrey Edsall (<b>195</b>:595, 1966) gave an excellent summary of the preventive therapy of rabies infection. He pointed out the necessity of administration of antirabies serum in cases where the rabies-prone injury suggests a very short incubation period for the possible rabies infection. The World Health Organization (WHO) considers antirabies serum obligatory in cases where the possibility of rabies infection is pronounced. At the same time, the WHO warns the attending physician that the responsibility for this therapy remains with him. The antirabies serum is a horse-blood derivative; therefore, the possibility of serum reaction exists even when the serum is administered together with epinephrine, antihistamines, cortisone, and heparin. When the serum is administered to persons who are sensitive to it in minute, highly diluted doses intravenously, the possibility of immediate reactions is less likely because of the rapid elimination of the serum in these cases. However, the
Nuclear Factor-κB Protects the Adult Cardiac Myocyte Against Ischemia-Induced Apoptosis in a Murine Model of Acute Myocardial Infarction
Authors: Arunima Misra, Sandra B. Haudek, Pascal Knuefermann, Jesus G. Vallejo, Zhijian J. Chen, Lloyd H. Michael, Natarajan Sivasubramanian, Eric N. Olson, Mark L. Entman, Douglas L. Mann
Journal: Circulation (2003)

Previous studies have shown that tumor necrosis factor (TNF) confers cytoprotective responses in cardiac myocytes. However, the mechanisms for the cytoprotective effects of TNF remain unknown. Given that TNF signals through nuclear factor kappaB (NF-kappaB) and given that NF-kappaB mediates cytoprotective responses, we asked whether NF-kappaB activation conferred cytoprotective responses in acute myocardial ischemia/infarction.We examined infarct size and the prevalence of apoptosis in transgenic mice harboring cardiac-restricted expression of a mutated IkappaBalpha protein (IkappaBalphaDeltaN) that prevents nuclear translocation of NF-kappaB in cardiac myocytes. Triphenyltetrazolium chloride staining showed that infarct size was approximately 50% greater (P<0.02) in the IkappaBalphaDeltaN mice compared with littermate controls at 24 hours. The prevalence of cardiac myocyte apoptosis was significantly greater (P<0.008) in the IkappaBalphaDeltaN mice compared with the littermate control mice 3 and 6 hours after left anterior descending occlusion. To explore the mechanism for these findings, we examined protein levels of c-IAP1, c-IAP2, and Bcl-2 as well as manganese superoxide dismutase and c-Jun NH2-terminal kinase activity. These studies showed that protein levels of c-IAP1 and Bcl-2 were significantly lower in the IkappaBalphaDeltaN mice, whereas there was no change in c-IAP2 levels, manganese superoxide dismutase, or c-Jun NH2-terminal kinase activity.Transgenic mice with a defect in activation of NF-kappaB have increased susceptibility to tissue injury after acute left anterior descending occlusion. These studies suggest that the cytoprotective effects of NF-kappaB are mediated, at least in part, by Bcl-2 or c-IAP1.
Exacerbation of Hereditary Hepatic Porphyria by Surreptitious Ingestion of an Unusual Provocative Agent — A Mouthwash Preparation
Authors: David R. Bickers, Lorraine Miller, Attallah Kappas
Journal: New England Journal of Medicine (1975)

EXACERBATIONS of acute intermittent porphyria are provoked by many commonly used drugs known to stimulate hepatic porphyrin-heme synthesis. In the patient described below, surreptitious ingestion of a seemingly innocuous agent — a mouthwash preparation — appeared to precipitate acute attacks of this disease.Case ReportA 48-year-old woman known to have acute intermittent porphyria was admitted to the Rockefeller University Hospital in severe clinical crisis in 1970. Urinary δ-aminolevulinic acid and porphobilinogen levels were highly elevated, and erythrocyte uroporphyrinogen synthetase activity was diagnostic for this genetic disease.1,2 She responded to therapy and was discharged within a month. A series of . . .