Endurance Exercise: More Pain, More Metabolic Gain
Authors: Mihoko Yoshino, Samuel Klein
Journal: Annals of Internal Medicine (2015)

Editorials3 March 2015Endurance Exercise: More Pain, More Metabolic GainMihoko Yoshino, MD, PhD and Samuel Klein, MDMihoko Yoshino, MD, PhDFrom Washington University School of Medicine, St. Louis, Missouri. and Samuel Klein, MDFrom Washington University School of Medicine, St. Louis, Missouri.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-0059 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Obesity is associated with a constellation of metabolic abnormalities, including insulin resistance, dyslipidemia, and excessive intrahepatic triglyceride content, which are important risk factors for type 2 diabetes and cardiovascular disease (1). Obese persons who have abdominal or upper-body obesity are at much higher risk for cardiometabolic diseases than those with lower-body, gluteal, or femoral obesity. Epidemiologic studies have consistently shown that waist circumference, which provides an index of abdominal fat mass, is a better predictor of whether a person will develop type 2 diabetes and coronary heart disease than body mass index (2).Reduction in body fat, particularly abdominal fat, ...References1. Klein S, Wadden T, Sugerman HJ. AGA technical review on obesity. Gastroenterology. 2002;123:882-932. [PMID: 12198715] CrossrefMedlineGoogle Scholar2. Lofgren I, Herron K, Zern T, West K, Patalay M, Shachter NS, et al. Waist circumference is a better predictor than body mass index of coronary heart disease risk in overweight premenopausal women. J Nutr. 2004;134:1071-6. [PMID: 15113947] CrossrefMedlineGoogle Scholar3. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults—the evidence report. National Institutes of Health. . Obes Res. 1998;6 Suppl 2:51S-209S. [PMID: 9813653] MedlineGoogle Scholar4. Wei M, Gibbons LW, Mitchell TL, Kampert JB, Lee CD, Blair SN. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med. 1999;130:89-96. [PMID: 10068380] LinkGoogle Scholar5. Lee CD, Blair SN, Jackson AS. Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. Am J Clin Nutr. 1999;69:373-80. [PMID: 10075319] CrossrefMedlineGoogle Scholar6. Holloszy JO, Schultz J, Kusnierkiewicz J, Hagberg JM, Ehsani AA. Effects of exercise on glucose tolerance and insulin resistance. Brief review and some preliminary results. Acta Med Scand Suppl. 1986;711:55-65. [PMID: 3535414] MedlineGoogle Scholar7. Mikines KJ, Sonne B, Farrell PA, Tronier B, Galbo H. Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am J Physiol. 1988;254:E248-59. [PMID: 3126668] MedlineGoogle Scholar8. Etgen GJ, Brozinick JT, Kang HY, Ivy JL. Effects of exercise training on skeletal muscle glucose uptake and transport. Am J Physiol. 1993;264:C727-33. [PMID: 8460676] CrossrefMedlineGoogle Scholar9. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, et al; American College of Sports Medicine. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116:1081-93. [PMID: 17671237] CrossrefMedlineGoogle Scholar10. Ross R, Hudson R, Stotz PJ, Lam M. Effects of exercise amount and intensity on abdominal obesity and glucose tolerance in obese adults. A randomized trial. Ann Intern Med. 2015;162:325-34. doi:10.7326/M14-1189 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Washington University School of Medicine, St. Louis, Missouri.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-2820.Corresponding Author: Samuel Klein, MD, Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St. Louis, MO 63110; e-mail, [email protected]wustl.edu.Current Author Addresses: Drs. Yoshino and Klein: Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St. Louis, MO 63110. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Exercise Amount and Intensity on Abdominal Obesity and Glucose Tolerance in Obese Adults Robert Ross , Robert Hudson , Paula J. Stotz , and Miu Lam Effects of Exercise Amount and Intensity on Abdominal Obesity and Glucose Tolerance in Obese Adults Robert Ross , Robert Hudson , Paula J. Stotz , and Miu Lam Metrics 3 March 2015Volume 162, Issue 5Page: 385-386KeywordsAttentionBlood plasmaExerciseGlucoseInsulin resistanceObesityOverweightType 2 diabetesWeight loss ePublished: 3 March 2015 Issue Published: 3 March 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...