tbuckley/cabot-search huggingface dataset:
Correction: Table 2 in Article on Zidovudine and Kaposi Sarcoma
Authors: H. Clifford Lane
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 March 1990Correction: Table 2 in Article on Zidovudine and Kaposi SarcomaH. Clifford Lane, MDH. Clifford Lane, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-5-388_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:There is an error in our article (1). The heading of column 7 of Table 2 (p. 45) titled "Samples with Levels ≥ 4µM" should read "Samples with Levels ≥ 0.4µM."...Reference1. LaneFalloonWalker HJR Zidovudine in patients with human immunodeficiency virus (HIV) infection and Kaposi sarcoma. Ann Intern Med. 1989;111:41-50. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H. Clifford Lane, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1990Volume 112, Issue 5Page: 388-388KeywordsKaposi sarcoma ePublished: 1 December 2008 Issue Published: 1 March 1990 PDF downloadLoading ...
1321 DIFFERENT INFLUENCE OF HCV-SPECIFIC T-CELL RESPONSES AND RS12979860 IL28B GENOTYPES ON KINETICS OF HCV CLEARANCE IN PATIENTS TREATED WITH PEGINTERFERON-RIBAVIRIN
Authors: N.I. Rallón, V. Soriano, E. Vispo, J. Garcia-Samaniego, C. Restrepo, A. Madejon, J.M. Benito
Journal: Journal of Hepatology (2011)
Cystic fibrosis and survival in patients with advanced lung disease
Authors: E. C. Dasenbrook
Journal: BMJ (2011)

rhDNase slows progression, and is strongly recommended in treatment guidelines

When Dorothy Andersen provided the first comprehensive description of cystic fibrosis in 1938,1 survival was often measured in days and months. However, the introduction of penicillin resulted in children recovering from previously fatal infective respiratory exacerbations.2 Subsequently, antibiotics given in combination with aggressive treatment of malnutrition resulted in some people with the condition living into adulthood.3 Today, a myriad therapeutic strategies are directed at the infectious, inflammatory, and mucociliary defects in cystic fibrosis.4 Combined with other non-pharmacological advances, children born today with cystic fibrosis are expected to live into their 50s⇓.5



Simon Fraser RVI/SPL

In the linked study (doi:10.1136/bmj.d1008), George and colleagues report on survival in a subgroup of adult patients with cystic fibrosis and advanced lung disease at the Royal Brompton Hospital, London, over 17 years (1990-2007).6 Median survival improved by four years in those entering the cohort between 2002 and 2003 compared with those who entered between 1990 and 1991. Their data suggest that the widespread introduction of recombinant human deoxyribonuclease (rhDNase) at the centre in …
A Novel Antioxidant Gene from <i>Mycobacterium tuberculosis </i>
Authors: Sabine Ehrt, Michael U. Shiloh, Jia Ruan, Michael Choi, Stuart Gunzburg, Carl Nathan, Qiao-wen Xie, Lee W. Riley
Journal: The Journal of Experimental Medicine (1997)

Among the major antimicrobial products of macrophages are reactive intermediates of the oxidation of nitrogen (RNI) and the reduction of oxygen (ROI). Selection of recombinants in acidified nitrite led to the cloning of a novel gene, noxR1, from a pathogenic clinical isolate of Mycobacterium tuberculosis. Expression of noxR1 conferred upon Escherichia coli and Mycobacterium smegmatis enhanced ability to resist RNI and ROI, whether the bacteria were exposed to exogenous compounds in medium or to endogenous products in macrophages. These studies provide the first identification of an RNI resistance mechanism in mycobacteria, point to a new mechanism for resistance to ROI, and raise the possibility that inhibition of the noxR1 pathway might enhance the ability of macrophages to control tuberculosis.
Abstract LB-12: Inhibition of the proliferation and invasion of hepatocellular carcinoma cells by lipocalin 2 through blockade of JNK and PI3K/Akt signaling
Authors: Eun-Kyoung Lee, Hyun-Jun Kim, Kong-Ju Lee, Ho-Jeong Lee, Dae-Ghon Kim, Soon-Won Hong, Yeup Yoon, Jang-Seong Kim
Journal: Cancer Research (2010)

Abstract Lipocalin 2 (Lcn2) has long been regarded to induce cellular proliferation because expression of Lcn2 has been associated in a variety of proliferative cells. Consistent with this, it has been demonstrated in the present study that Lcn2 was significantly elevated in human HCC (hepatocellular carcinoma) tissues compared with the non-tumor liver tissues. However, the roles of Lcn2 in hepatocarcinogenesis are far from clear. To investigate the effects of Lcn2 expression on the hepatocarcinogenesis, Chang liver and SK-Hep1, the HCC cell lines, were genetically manipulated to express Lcn2 and their effects on the proliferation and invasion of HCC cells were analyzed. Ectopic expression of Lcn2 in HCC cells significantly inhibited the growth of HCC cells in vitro and in vivo. In addition, its expression reduced the invasive potential of cells and inhibited the expression of matrix metalloproteinase 2 (MMP-2). Lcn2 may exert its function partly through the inhibition of the c-Jun N-terminal kinase (JNK) and phosphatidyl inositol 3′-kinase (PI3K)/Akt signaling pathways in HCC cells, since selective inhibition of those pathways using pharmacological inhibitors significantly inhibited the proliferation, invasion and MMP-2 expression, whereas Lcn2 expression suppressed the JNK and PI3K/Akt pathways. In conclusion, these results clearly indicate that Lcn2 may play a protective role in the progression of HCCs by suppressing the proliferation and invasion of HCC cells, although clinical significance of the present findings remains to be evaluated. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-12.
Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
Authors: Jia Zhu, David M. Koelle, Jianhong Cao, Julio Vazquez, Meei Li Huang, Florian Hladik, Anna Wald, Lawrence Corey
Journal: The Journal of Experimental Medicine (2007)

Cytotoxic CD8+ T cells play a critical role in controlling herpes simplex virus (HSV) infection and reactivation. However, little is known about the spatiotemporal dynamics of CD8+ T cells during HSV lesion evolution or about their involvement in immune surveillance after lesion resolution. Using quantum dot–conjugated peptide–major histocompatibility complex multimers, we investigated the in vivo localization of HSV-2–specific CD8+ T cells in sequential biopsies of human genital skin during acute, resolving, and healed stages of HSV-2 reactivation. Our studies revealed that functionally active CD8+ T cells selectively infiltrated to the site of viral reactivation. After lesion healing in concert with complete reepithelialization and loss of HSV DNA from skin biopsies, HSV-2–specific CD8+ T cells persisted for more than two months at the dermal–epidermal junction, adjacent to peripheral nerve endings. In two out of the six sequentially studied individuals, HSV-2 DNA reappeared in clinically and histologically normal–appearing skin. Detection of viral DNA was accompanied by increased numbers of both HSV-specific and total CD8+ T cells in the dermis. These findings indicate that the frequency and clinical course of HSV-2 reactivation in humans is influenced by virus-specific CD8+ T cells that persist in peripheral mucosa and genital skin after resolution of herpes lesions.
Corrigendum to “Effects of Once-Daily Tadalafil on Erectile Function in Men with Erectile Dysfunction and Signs and Symptoms of Benign Prostatic Hyperplasia” [Eur Urol 2009;56:727–36]
Authors: Hartmut Porst, Kevin T. McVary, Francesco Montorsi, Peter Sutherland, Albert Elion-Mboussa, Anne M. Wolka, Lars Viktrup
Journal: European Urology (2011)
THE DIAGNOSIS AND TREATMENT OF STONE IN THE URETER
Authors: HERMAN L. KRETSCHMER
Journal: JAMA (1923)

The high plane of efficiency that has been achieved in the treatment of stone in the ureter is directly due to the splendid developments in the field of roentgenology, the perfection of urologic diagnostic instruments and the results derived from the combination of these two factors. With the improved technic in roentgen-ray examinations, recently fortified by the new Potter diaphragm, stones in the ureter are being more and more frequently demonstrated. As for the perfection of the various types of urologic instruments, this scarcely needs comment at this time. The treatment of stone in the ureter has passed through three more or less arbitrary periods. The first period began about the time the use of the roentgen rays was introduced as a diagnostic measure. Many shadows were found that were wrongly interpreted, and it is unpleasant to record that as a result patients were subjected to a needless open operation
Sustained Delivery Fluocinolone Acetonide Vitreous Inserts Provide Benefit for at Least 3 Years in Patients with Diabetic Macular Edema
Authors: Peter A. Campochiaro, David M. Brown, Andrew Pearson, Sanford Chen, David Boyer, Jose Ruiz-Moreno, Bruce Garretson, Amod Gupta, Seenu M. Hariprasad, Clare Bailey, Elias Reichel, Gisele Soubrane, Barry Kapik, Kathleen Billman, Frances E. Kane, Kenneth Green
Journal: Ophthalmology (2012)
Determinants of team-sport performance: implications for altitude training by team-sport athletes
Authors: David J Bishop, Olivier Girard
Journal: British Journal of Sports Medicine (2013)

Team sports are increasingly popular, with millions of participants worldwide. Athletes engaged in these sports are required to repeatedly produce skilful actions and maximal or near-maximal efforts (eg, accelerations, changes in pace and direction, sprints, jumps and kicks), interspersed with brief recovery intervals (consisting of rest or low-intensity to moderate-intensity activity), over an extended period of time (1–2 h). While performance in most team sports is dominated by technical and tactical proficiencies, successful team-sport athletes must also have highly-developed, specific, physical capacities. Much effort goes into designing training programmes to improve these physical capacities, with expected benefits for team-sport performance. Recently, some team sports have introduced altitude training in the belief that it can further enhance team-sport physical performance. Until now, however, there is little published evidence showing improved team-sport performance following altitude training, despite the often considerable expense involved. In the absence of such studies, this review will identify important determinants of team-sport physical performance that may be improved by altitude training, with potential benefits for team-sport performance. These determinants can be broadly described as factors that enhance either sprint performance or the ability to recover from maximal or near-maximal efforts. There is some evidence that some of these physical capacities may be enhanced by altitude training, but further research is required to verify that these adaptations occur, that they are greater than what could be achieved by appropriate sea-level training and that they translate to improved team-sport performance.
Attempt to strip abortion providers of counselling role is defeated
Authors: N. Hawkes
Journal: BMJ (2011)

An attempt to strip some abortion providers of the duty to offer advice to women about abortion was heavily defeated in a vote in the House of Commons.

Nadine Dorries, a Conservative backbencher, moved an amendment to the Health and Social Care Bill that would have insisted counselling be provided by independent agencies and not by abortion providers such as Marie Stopes or the British Pregnancy Advisory Service (bpas). Ms Dorries argued that it was wrong for organisations that had a financial interest in carrying out terminations also to be providing counselling.

If passed, the effect would have been to give a greater …
Deaths under Anaesthetics
Authors: E. H. Jacob
Journal: BMJ (1886)

wounded is not stated.The point, however, which M. Pasteur leaves most in doubt, in a great number of cases, is the most important point of all-namely, whether the dog was really rabid.Several children were sent to Paris from Newark, in the United States, under the impression that the dog by which they had been bitten was rabid From a paragraph in the New York .1ledicalRecord, it would appear that this was niot the case ; for seven other dogs bitten by it, and kept under observation until March 2nd, did not become rabid.His last paper makes it clear that AI.Pasteur is fully alive to this grave source of fallacy; and, in criticising him, it is only fair to remenmber that, not being a bird, as Sir Boyle Roche would have said, he cannot personally verify the diagnosis of rabies wlhich he obtainis from the veterinary or medical practitioner.The first duty of the Commission would be to examine into this; the number of cases at present published, in which the evidence is conclusive, is only four at most; and the Commission, I take it, would have to make observations for itself.M. Pasteur does not, as yet, ap- pear to have had as many as a hundred patients in a month; but, assuming that, within that time, the Commission witnessed the com- mencement of a hundred inioculationis, then, since as a rule each pa- tient has been bitten by a different dog, some sixty or seventy journeys throughout the length and breadth of Europe, and the careful observa- tion, perhaps for several days, of as many dogs, post mortegn examina- tions, and secondary test inoculations, would be necessary.The period of incubation of hydrophobia mnay be at least as much as sixty days, and all the patients inoculated would have to be kept under ob- servation for at least this period.The best available statistics show that, of onie hundredl persons bitten by rabidl dogs, only twenty will develope hydrophobia.M. Pasteur, it is true, includes persons bitten on parts of the body covered by clothes, unless the clothes arc torn; buit, on the other hand, a certain unknown proportion of his patients have not been bitten by rabid dogs.It is, therefore, fair to assume that, if the Comulission observes a consecutive series of a hundred cases, its report will be founded on not more than twenty cases of potential hydrophobia.To do this, with any approach to completeness, will take three months' woork ; and yet, the settlement of these elementary questions: Was the dog mad?Did the patient escape hydrophobia?leaves us still at the threshold of the inquiry.-Yourstruly, DAWSON WILLIAMS.EMIMET'S OPERATION.Sin,-I am sorry to trespass once more upon your much-contested ppace.Dr.
Optogenetic Countering of Glial Acidosis Suppresses Glial Glutamate Release and Ischemic Brain Damage
Authors: Kaoru Beppu, Takuya Sasaki, Kenji F. Tanaka, Akihiro Yamanaka, Yugo Fukazawa, Ryuichi Shigemoto, Ko Matsui
Journal: Neuron (2014)
Patterns of allergic sensitisation and cross-reactivity between Blomia tropicalis and Dermatophagoides farinae: A comparative study
Authors: AC Angus, S Chua, ST Wun, M Moh, V Mahakittikun, C Bunnag, Pakit Vichyanond, DY Wang, Bee Wah Lee, S Lim
Journal: Journal of Allergy and Clinical Immunology (2002)
570 CONTRAST-ENHANCED ULTRASONOGRAPHY IN EVALUATING HEPATIC METASTASES FROM NEUROENDOCRINE TUMOURS
Authors: S. Massironi, D. Conte, V. Sciola, L. Pirola, S. Paggi, M. Fraquelli, C. Ciafardini, R. Rossi, M. Peracchi
Journal: Journal of Hepatology (2010)
Mesangiocapillary (membranoproliferative) glomerulonephritis and rheumatoid arthritis.
Authors: H C Ting, F Wang
Journal: BMJ (1977)

Bladder rupture in multiple sclerosisWe describe two cases of spontaneous bladder rupture in patients with multiple sclerosis. Case reportsCase 1-A 52-year-old woman presented with a two-day history of haematuria, dysuria, and frequency.She had had difficulty in walking and urgency for five years.On examination she was dehydrated and had loin and abdominal tenderness.She soon became shocked and febrile, and laparotomy showed extensive peritonitis.The bladder was inflamed, hypertrophic, and perforated through the fundus.Neurological assessment during convalescence showed bilateral optic atrophy, spastic tetraparesis, and loss of vibration sense below the iliac crests.Cerebrospinal fluid protein was 0-6 g/l and IgG 0 1 1 g!l.Case 2-A 47-year-old woman who had had multiple sclerosis for 11 years presented with vomiting, abdominal pain, and haematuria.She had had recurrent urinary tract infections and urgency for two years.Two weeks before admission she had become incontinent of urine and an exacerbation of her leg weakness had occurred.She was catheterised and treated with distigmine and corticotrophin.On examination she was febrile and dehydrated and had a distended abdomen and loin tenderness.There was noticeable spasticity of all four limbs and optic atrophy.Abdominal radiog- raphy showed fluid levels and gas under the diaphragm.At laparotomy peritonitis and a large, trabeculated, hypertrophic bladder with a perforation in the fundus were found.
Epidemiologic Study Design for Investigating Respiratory Health Effects of Complex Air Pollution Mixtures
Authors: Douglas W. Dockery
Journal: Environmental Health Perspectives (1993)

Epidemiologic studies of the respiratory health effects of air pollution are intrinsically difficult because exposure is common, expected effects at con- centrations found in developed countries are weak, random misclassification of exposure is common, and the respiratory health indicators have multiple etiologies.Exposures to air pollutants also are multidimensional, generally consisting of a mixture of gases and particles.In this paper, epidemiologic study designs are described, and their potential for evaluating effects of complex pollutant mixtures are discussed.Power to detect the independent effects of individual pollutants in a complex pollutant mixture or to measure their interactions is in general very weak unless the study is specifically designed to test such hypotheses.However, with innovative and creative design, the independent and joint effects of multiple pollutants should be estimable in epidemiologic studies.
Reperfusion induced arrhythmias following ischaemia in intact rat heart: role of intracellular calcium
Authors: W. W Brooks, C. H Conrad, J. P Morgan
Journal: Cardiovascular Research (1995)

The aim was to test the hypothesis that reperfusion induced arrhythmias are associated with major alterations in intracellular calcium ([Ca2+]i) regulation.Intracellular calcium, epicardial electrical potentials, and isovolumetric left ventricular pressure were simultaneously recorded in isolated perfused intact rat hearts during ischaemia (10 min) and reperfusion. [Ca2+]i was measured using the bioluminescent calcium indicator aequorin.Neither ventricular tachycardia nor ventricular fibrillation occurred during ischaemia. However, during the first minute of reperfusion ventricular tachycardia or fibrillation were frequently observed. Cellular calcium was altered by varying the perfusate calcium ([Ca2+]o; 0.5, 1.0, and 3.0 mmol.litre-1). 0% (0/6), 50% (5/10), 91% (10/11), respectively, of hearts showed ventricular tachycardia, ventricular fibrillation, or both upon reperfusion (P < 0.001, 0.5 v 3.0 mmol.litre-1). At all [Ca2+]o values examined, early ischaemia was associated with a rapid decrease in developed pressure and transient increase in the peak calcium transient followed by a gradual decline and subsequent increase in diastolic calcium during late ischaemia. The initiation of ventricular tachycardia/fibrillation upon reperfusion was immediately preceded by large increases in the amplitude of the calcium transient. These increases in systolic calcium were not seen in hearts in which ventricular arrhythmias did not occur.The association between reperfusion induced abrupt increases in peak calcium and the occurrence of ventricular tachycardia or fibrillation suggests that intracellular calcium transients may have a significant role in initiating these ventricular arrhythmias.
Alemtuzumab for Refractory Celiac Disease in a Patient at Risk for Enteropathy-Associated T-Cell Lymphoma
Authors: Santiago Vivas, José María Ruiz de Morales, Fernando Ramos, Dimas Suárez-Vilela
Journal: New England Journal of Medicine (2006)

To the Editor: A 56-year-old woman had a two-year history of refractory celiac disease for which she had taken prednisone (20 mg per day) for the previous six months, during which time her condition had worsened despite a gluten-free diet. Duodenal biopsy showed severe atrophy with crypt hyperplasia and increased intraepithelial lymphocyte counts. On immunohistochemical analysis, the cytoplasm was positive for CD3 and negative for CD4 and CD8 (Figure 1). Flow-cytometric analysis of intraepithelial lymphocytes showed that more than 50 percent of the cells expressed T-cell receptor γδ (TCRγδ). In addition, we identified a second aberrant population of intraepithelial lymphocytes, . . .
Researcher from study alleging link between MMR and autism warns of measles epidemic
Authors: S. Mayor
Journal: BMJ (2003)

The dangers of complications associated with measles and rubella in unvaccinated children outweigh any concerns about the safety of the measles, mumps, and rubella (MMR) vaccine, argued one of the authors of the study that first raised the question of a link between MMR and autism, in a letter published last week.

In a letter to the Lancet (2003;362:1498-9), Dr Simon Murch, a consultant gastroenterologist at the Royal Free and University College Medical School, London, warned that a recent report of encephalitis associated with measles in immunosuppressed children ( Lancet 2003 ;362: 832) emphasised the grave risk posed by children not having …
Response to Budesonide/Formoterol Pressurized Metered-Dose Inhaler (BUD/FM pMDI) by Patient's Sex in Non-Black and Black Populations With Asthma
Authors: S.M. Meltzer, S.L. Spector, T. Uryniak, U.J. Martin
Journal: Journal of Allergy and Clinical Immunology (2011)