tbuckley/cabot-search huggingface dataset:
Effect of atrial systole on canine and porcine coronary blood flow.
Authors: R F Bellamy
Journal: Circulation Research (1981)

A feature of phasic coronary flow patterns recorded in conscious chronically instrumented dogs is the atrial cove--a transient depression of arterial flow that occurs during atrial systole. The association between the hemodynamic effects of atrial systole and the atrial cove was studied in anesthetized dogs and pigs with complete heart block. Many atrial coves are available for study in these preparations because atrial activity continues unabated during the diastolic ventricular arrest that follows cessation of electrical pacing. The effect of atrial systole is to translate the pressure-flow relation found during diastole to a higher intercept pressure without change in slope. The increase in the intercept pressure equals the increase in intramyocardial pressure measured with microtransducers embedded in the left ventricular wall. The decrement in flow during the atrial cove is a direct function of the change in intramyocardial pressure and an inverse function of coronary vascular resistance. Each atrial systole is associated with a forward flow transient in the coronary veins, the peak of which occurs at the same instant as does the nadir of atrial flow. These data suggest that the coronary vessels are acting as collapsible tubes and that the waterfall model of the coronary circulation is applicable. The following sequence is proposed to account for the atrial cove. Atrial systole ejects a bolus of blood into the left ventricle increasing both ventricular cavity and intramyocardial pressures. The increase in intramyocardial pressure raises the back pressure opposing coronary flow, reducing the arterial perfusion pressure gradient and causing flow to fall.
Dabigatran led to less major bleeding than warfarin in younger but not older patients with atrial fibrillation
Authors: Marcel Levi
Journal: Annals of Internal Medicine (2011)

Source Citation Eikelboom JW, Wallentin L, Connolly SJ, et al. Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the Randomized Evaluation of Long-term Anticoagulant Therapy (RE-LY) Trial. Circulation. 2011;123:2363-72. 21576658
Albuterol-induced downregulation of Gsα accounts for pulmonary β2-adrenoceptor desensitization in vivo
Authors: Paul A. Finney, Maria G. Belvisi, Louise E. Donnelly, Tsu-Tshen Chuang, Judith C.W. Mak, Carol Scorer, Peter J. Barnes, Ian M. Adcock, Mark A. Giembycz
Journal: Journal of Clinical Investigation (2000)

The aim of the present study was to develop a chronic in vivo model of pulmonary β2-adrenoceptor desensitization and to elucidate the nature and molecular basis of this state. Subcutaneous infusion of rats with albuterol for 7 days compromised the ability of albuterol, given acutely, to protect against acetylcholine-induced bronchoconstriction. The bronchoprotective effect of prostaglandin E2, but not forskolin, was also impaired, indicating that the desensitization was heterologous and that the primary defect in signaling was upstream of adenylyl cyclase. β2-Adrenoceptor density was reduced in lung membranes harvested from albuterol-treated animals, and this was associated with impaired albuterol-induced cyclic adenosine monophosphate (cAMP) accumulation and activation of cAMP-dependent protein kinase ex vivo. Gsα expression was reduced in the lung and tracheae of albuterol-treated rats, and cholera toxin–induced cAMP accumulation was blunted. Chronic treatment of rats with albuterol also increased cAMP phosphodiesterase activity and G protein–coupled receptor kinase-2, but the extent to which these events contributed to β2-adrenoceptor desensitization was unclear given that forskolin was active in both groups of animals and that desensitization was heterologous. Collectively, these results indicate that albuterol effects heterologous desensitization of pulmonary Gs-coupled receptors in this model, with downregulation of Gsα representing a primary molecular etiology.
ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome
Authors: Tobias Willer, Hane Lee, Mark Lommel, Takako Yoshida-Moriguchi, Daniel Beltran Valero de Bernabe, David Venzke, Sebahattin Cirak, Harry Schachter, Jiri Vajsar, Thomas Voit, Francesco Muntoni, Andrea S Loder, William B Dobyns, Thomas L Winder, Sabine Strahl, Katherine D Mathews, Stanley F Nelson, Steven A Moore, Kevin P Campbell
Journal: Nature Genetics (2012)
THE IRRITANT EFFECT OF SOAP UPON THE NORMAL SKIN.
Authors: F. RAY BETTLEY, ELAINE DONOGHUE
Journal: British Journal of Dermatology (1960)

Journal Article THE IRRITANT EFFECT OF SOAP UPON THE NORMAL SKIN. Get access F. RAY BETTLEY, F.R.C.P., F. RAY BETTLEY, F.R.C.P. Physician for Diseases of the Skin Search for other works by this author on: Oxford Academic Google Scholar ELAINE DONOGHUE, M.B., B.S. ELAINE DONOGHUE, M.B., B.S. Research Assistant The Institute of Clinical Research, Middlesex Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 72, Issue 2, 1 February 1960, Pages 67–76, https://doi.org/10.1111/j.1365-2133.1960.tb13847.x Published: 01 February 1960
Author Misrepresentation in the Submission of Redundant Papers
Authors: Qais Al-Awqati, Eric G. Neilson
Journal: Journal of the American Society of Nephrology (2008)

When are two original papers by the same authors redundant? Variations in study design around similar themes might enable plausible claims of distinction, but the average reader can quickly perceive commonality and overlap. Authors use all or part of the same data set, come to similar conclusions that have no incremental value, produce overlapping communications that could easily have been distilled to one, and waste the time of our reviewers and readers. Redundant publications also deprive other authors of space to have their own articles chosen for print in well-regarded journals. This is annoying and usually caught during the review process, except when it is not disclosed. Our journals ask each submitting author at the time of submission whether they have other, similar manuscripts under review elsewhere. When authors fail to report related manuscripts, it disturbs choices made during review and the relative success of all submissions. It also leaves us with the ethical dilemma of misrepresentation. Not too long ago, Kidney International and Journal of the American Society of Nephrology published what we believe were largely redundant articles by the same group of authors. At the time of submission, the authors misled us by stating they had no like article under review, knowing full well within days of their submission to one journal they were submitting a related article to the other. Neither manuscript referenced the other, and neither journal was told of a related article at the time the authors uploaded their revisions. Our journals collectively receive many more promising manuscripts than they can accommodate. Would it have made a difference if these recent authors had told of us of their related article? Quite possibly, and our reviewers and editors were entitled to consider the potential for overlap in their decision to review and accept. Because of this, both journals are banning all authors in both papers from publishing their work in either journal for the next 2 years. This will also be our approach going forward. Sadly, we live in a world indifferent to pretense. In PubMed, there are more than 30 journal commentaries lamenting the problem of redundant publications.1–4 In our circumstance, neither journal was given the chance to decide for itself. At some point, it has to stop. We thank an early reader of both journals for pointing out the current mishap. Disclosures None.
A CASE OF ACUTE INFLAMMATION OF THE BRAIN IN A CHILD.Read at a meeting of the Kalamazoo Academy of Medicine, May 15, 1894.
Authors: C. VAN ZWALUWENBURG
Journal: JAMA (1894)

In stating the following case, our attention is directed to the etiology and diagnosis of acute diseases of the brain; especially with reference to the effects of injuries; to the medico legal question involved; to the relation of infection to brain disease, and to the question of trephining after an injury. The subject of the paper was a boy of Holland parentage, with an excellent family history, both as regards bodily and mental disease. He was a well developed child and the picture of health. No history of physical illness excepting a few attacks of gastro-intestinal trouble. On March 20, 1894, he complained of headache and vomited considerably. The following day he fell, or rather slipped off the steps of a porch in a faint, as described by his parents. On this day or the day preceding, the exact date could not be determined, he was hit on the head
Multiple Myeloma and Benign Monoclonal Gammopathy: Differentiation by Immunofluorescence of Lymphocytes
Authors: FOLKE D. LINDSTRÖM
Journal: Annals of Internal Medicine (1973)

The proportions of T and B cells among peripheral blood lymphocytes were studied in 46 patients with plasma cell myeloma and in 14 patients with benign monoclonal gammopathy. Significant lowering (P < 0.001) of percentages of B cells having normal surface Ig was found in the myeloma group, whereas the patients with benign M-components showed normal proportions of B cells. Mean percentage of total B cells in myeloma patients was 10.3% ± 6.9%, whereas mean B-cell value in benign monoclonal gammopathy was 21.4% ± 11.7%. Normal B-cell values were 22.9% ± 7.1%. Myeloma patients in remission tended to have normal proportions of B cells. Individually specific or idiotypic M-component antigenic Ig markers were present in relatively high percentages in peripheral blood lymphocytes from two patients with myeloma, whereas the reverse was true in a patient with a benign M-component. There was some overlap in total B-cell values between patients with established myeloma and those with benign monoclonal gammopathy.
Tranquilizers not overprescribed for anxiety
Authors: Milan Korcok
Journal: JAMA (1981)

A majority of recently surveyed Texas physicians believe their formal training in the management of anxiety has been inadequate. What's more, they are staunchly conservative in terms of handing out minor tranquilizers to their anxious patients. In fact, the survey, carried out by Carl D. Chambers, PhD, associate professor and director of Health Services Administration at Ohio University, Athens, and colleagues showed that 67% of the 150 physicians interviewed do not believe that removal from the market of minor tranquilizers, particularly benzodiazepines, would restrict their ability to practice. Only 6% feel that prescribing of benzodiazepines is the most effective means of addressing persistent anxiety. The majority of physicians interviewed think that office counseling is the most effective means of managing anxiety, but almost two out of three believe they did not receive sufficient training in this phase of medicine in school or during internship or residency. The survey was prompted
Post-transcriptionally Regulated Expression System in Human Xenogeneic Transplantation Models
Authors: Hui-Ling Rose Lee, Chiann-Chyi Chen, Timor Baasov, Yacov Ron, Joseph P Dougherty
Journal: Molecular Therapy (2011)

Cells have developed a mechanism to discriminate between premature termination codons (PTCs) and normal stop codons during translation, sparking vigorous research to develop drugs promoting readthrough at PTCs to treat genetic disorders caused by PTCs. It was posed that this concept could also be applied to regulated gene therapy protocols by incorporating a PTC into a therapeutic gene, so active protein would only be made after administration of a readthrough agent. The strengths of the system are highlighted here by results demonstrating: (i) background expression levels were reduced to 0.01% to 0.0005% of wild type in unselected mass populations of cells depending upon the specific stop codon utilized and its position within the gene; (ii) expression levels responded well to multiple "On" and "Off" regulation cycles <i>in vivo</i> in human xenograft systems; (iii) the level of induction approached three logs using aminoglycoside activators including NB54, a newly synthesized aminoglycoside with significantly reduced toxicity; and (iv) expression levels could be appreciably altered when employing different promoters in a variety of cell types. These results strongly support the contention that this system should have important clinical applications when tight control of gene expression is required.
DoH seems to have underestimated incidence of venous thromboembolism in users of combined oral contraceptives
Authors: R A Lawrenson, A Whalley, E Simpson, R D T Farmer
Journal: BMJ (1999)

EDITOR—Mayor reports the Department of Health's change of view on the use of third generation oral contraceptives.1 The department now proposes that women may be prescribed these newer oral contraceptives provided that they are “fully informed.” It is reported that the new package insert will include a statement that the risk of deep venous thrombosis is 15 per 100 000 among women using second generation pills and 25 per 100 000 among users of third generation …
Subacute Tuberculous Constrictive Pericarditis
Authors: José Alberto de Agustín, Jordi Álvarez, Angel García, Juan José González-Ferrer, Ivan Javier Núñez-Gil, Pedro Marcos-Alberca, Covadonga Fernández-Golfín, Carlos Macaya, José Zamorano
Journal: Journal of the American College of Cardiology (2012)
The Jake Walk Blues
Authors: JOHN P. MORGAN
Journal: Annals of Internal Medicine (1976)

In 1930 thousands of cases of muscle pain, weakness of upper and lower extremities, and minimal sensory impairment occurred in the United States. The illness was caused by the consumption of an adulterated Jamaica ginger extract ("Jake"), an illicit beverage then popularly used in the southern and midwestern United States to circumvent prohibition statutes. The additive tri-ortho-cresyl phosphate caused severe, only partially reversible damage to the spinal cord and peripheral nervous tissue. Victims with resultant gait impairment, sometimes permanent, were said to have the "Jake Leg" or "Jake Walk." Twelve commercial phonographic recordings made between 1928 and 1934 by southern rural artists, white and black, refer to Jake or Jake-induced infirmity. These reveal preepidemic cultural familiarity with Jake, and the later, postepidemic performances reflect a whimsical, even cynical, cultural attitude that those with "Jake Leg" were suffering the wages of sin and should not be regarded as objects of pity or sympathy.
Response to the Methylation Inhibitor Dihydro-5-azacytidine in Mesothelioma Is Not Associated with Methylation of p16INK4a: Results of Cancer and Leukemia Group B 159904
Authors: Robert A. Kratzke, Xiaofei Wang, Long Wong, Marian G. Kratzke, Mark R. Green, Everett E. Vokes, Nicholas J. Vogelzang, Hedy L. Kindler, Jeffrey A. Kern
Journal: Journal of Thoracic Oncology (2008)
Kunitz Soybean Trypsin Inhibitor
Authors: Leonard A. Moroz, William H. Yang
Journal: New England Journal of Medicine (1980)

ALTHOUGH foods are common causes of anaphylaxis,1 the responsible allergens, with the exception of the one from codfish muscle,2,3 remain uncharacterized. Soybean products are recognized causes1 and are commonly encountered, often in an unrecognizable form,4 in processed and restaurant foods. In some cases, IgE antibody has been documented by radioallergosorbent methods and skin testing with crude soybean extracts, rather than purified allergens, as test materials.5,6 Proteinase inhibitors from plants are widely used in biochemical research and are highly characterized molecules.7 The best known is the Kunitz soybean trypsin inhibitor (SBTI).8-10 This report documents a specific IgE-antibody response . . .
Other Studies Show Aspirin Use Is High
Authors: Jonathan Brown
Journal: PLoS Medicine (2006)

I would like to thank PLoS Medicine for publishing Lacasse and Leo's important and methodical Essay that debunks the "chemical imbalance" advertisements for psychiatric drugs [1].Why would the United States Food and Drug Administration (FDA) approve such ads?Our human rights group, MindFreedom International, has been asking that question for a long time.On behalf of MindFreedom, US Senator Ron Wyden contacted the FDA for an explanation about why they approve such advertising.In their responsewhich took over one year to receive-the FDA could cite no scientifi c literature or studies.It turns out there's a good reason that the FDA can't fi nd any scientifi c evidence for the claims of a "chemical imbalance" in these ads: the scientifi c evidence in support of the serotonin hypothesis is very weak.Readers who would like more information about the psychiatric industry's advertising suggesting a "chemical imbalance" in depression may be interested in the following:(1) MindFreedom's debate with Pfi zer, manufacturer of Zoloft, available at http:⁄⁄www.mindfreedom.org/mindfreedom/pfi zerlies.shtml,and (2) a historic debate with the American Psychiatric Association resulting from MindFreedom's 2003 hunger strike, available at http:⁄⁄www.mindfreedom.org/mindfreedom/hungerstrike.shtml
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Authors: Vincent Favaudon, Laura Caplier, Virginie Monceau, Frédéric Pouzoulet, Mano Sayarath, Charles Fouillade, Marie-France Poupon, Isabel Brito, Philippe Hupé, Jean Bourhis, Janet Hall, Jean-Jacques Fontaine, Marie-Catherine Vozenin
Journal: Science Translational Medicine (2014)

Pulsed, ultrahigh dose-rate irradiation is safer than standard radiotherapy for the treatment of lung cancer and selectively spares normal tissue.
Hospital Design and Function
Authors: Carl W. Walter
Journal: JAMA (1965)

The initiation of a project to create new hospital facilities promptly induces controversy that may result in needless disunity and ineffective pursuit of the objective: health facilities to enable the profession to serve the public optimally. The community and the project suffer from the ill will engendered. Prevention of this turbulence is the purpose of this newly published monograph, which charts the complex process of developing a health facility from the moment of conception until turnkey day. It is a unique contribution to a sparse literature. The book is well organized and extraordinarily readable. The author maintains a high level of interest throughout the detailed exposition of how to program the design of a hospital and get it built. The author's approach to planning is illustrated by specific data upon which to base judgments. Indeed, many of these data cannot be found elsewhere in the literature. The diagrammatic illustrations, tables,
Cardiovascular Disease and Vasectomy
Authors: M. J. Goldacre, T. R. Holford, M. P. Vessey
Journal: New England Journal of Medicine (1983)

We performed two epidemiologic studies using routine abstracts of medical records to test the hypothesis that vasectomy may predispose men to cardiovascular disease. In a case-control study 1512 men who were under 55 years of age and had a history of myocardial infarction, stroke, or hypertension were matched with 3024 controls with other conditions; 2.4 per cent of the cases and 2.7 per cent of the controls were identified as having undergone vasectomy (risk ratio, 0.9; 95 per cent confidence limits, 0.6 to 1.3). In a cohort study data covering a mean period of 6 1/2 years after surgery were available on 1764 men who had had a vasectomy and on three comparison cohorts of men who had had other minor surgical procedures. There was no evidence of an increased risk of cardiovascular disease associated with vasectomy. There is no consistent evidence from our studies to support the hypothesis that in the short term vasectomy predisposes young men to cardiovascular disease.
Eosinophilia Apparently Related to Cigarette Smoking
Authors: Irwin Schoen, Marvin Pizer
Journal: New England Journal of Medicine (1964)

THERE are clinically a moderate number of patients with eosinophilia of unknown etiology or eosinophilia associated with mild allergic signs and symptoms (hay fever and so forth) without demonstrable allergens or other specific etiologic agents. The laboratory is occasionally called upon to evaluate a patient with eosinophilia by the examination of multiple fecal specimens for ova and parasites to complete an otherwise fruitless etiologic medical work-up. Since these cases usually do not reveal any parasitic basis for the eosinophilia the possibility of relating the abnormality to tobacco smoking came to mind. A review of the literature did not reveal any . . .
Value of Postmortem Eye Examination
Authors: Alice G. Karpik
Journal: JAMA (1980)

To the Editor.—  The efficacy of enucleating the eye as treatment for uveal melanoma has recently been questioned after observing an unexpected postoperative increase in mortality from metastatic disease.1Although enucleation has been the standard treatment for more than a century, the natural history of the disease remains obscure.2Cancer statistics on incidence and effects of treatment of any tumor are compromised unless confirmed by postmortem examination (221:1471, 1972).3This problem is particularly serious for uveal melanoma statistics, as this case demonstrates.  Report of a Case.—  A 61-year-old woman with a 15-year history of alcohol abuse and a four-month history of weakness and diffuse abdominal pain was first seen elsewhere. Findings from liver biopsy specimen showed hepatocyte atypia and regenerative nodules. The clinical impression was alcoholic cirrhosis.  Three weeks later, the patient was admitted to Rush-Presbyterian-St Luke's Medical Center with abdominal enlargement and diarrhea. She had daily
On Science Business
Authors: Lewis Thomas
Journal: New England Journal of Medicine (1980)

IT seems only yesterday that cell biology was the purest and most basic of all fields in biomedical research, in constant need of defense before skeptical Congressional subcommittees, hard to justify for tax-payers' funds except on grounds of rather vague prospects for its future usefulness, years off. Now, almost overnight, it looks like a way to make lots of money. The big pharmaceutical houses are already doing cell biology in great vats, while tiny new corporations are sprouting everywhere at the edges of university towns for the development of innovative and patentable technologies. Cells are not just useful, they are . . .
In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification.
Authors: E S Metcalf, N H Sigal, N R Klinman
Journal: The Journal of Experimental Medicine (1977)

The susceptibility to in vitro tolerance induction has been implicated as a characteristic of B cells early in their development, since DNP-reactive B cells are tolerizable only during the first days after birth, and 25% of adult bone marrow cells are tolerizable. In the present study, a modification of the in vitro splenic focus technique was utilized to determine if PC-specific B cells, by virtue of their late expression (approximately 1 wk post-parturition), also display susceptibility to tolerance induction. The results demonstrate that at 7-10 days after birth, when over 90% of the DNP-specific splenic B cells are resistant to tolerance induction, the majority of PC-specific B cells are tolerizable. These results re-emphasize tolerance susceptibility as a characteristic of developing clones, confirm the late acquisition of PC-specific B cells, and support the contention that the acquisition of the specificity repertoire is a highly ordered, specifically predetermined process which is independent of antigen-driven events.