The Presence of Anti-gamma Globulin Factors in Sera of Patients with Active Pulmonary Tuberculosis
Authors: JACQUES M. SINGER
Journal: Annals of Internal Medicine (1962)

Article1 April 1962The Presence of Anti-gamma Globulin Factors in Sera of Patients with Active Pulmonary TuberculosisJACQUES M. SINGER, M.D., CHARLES M. PLOTZ, M.D., F.A.C.P., FRANCISCO M. PERALTA, M.D., HAROLD C. LYONS, M.D.JACQUES M. SINGER, M.D.Search for more papers by this author, CHARLES M. PLOTZ, M.D., F.A.C.P.Search for more papers by this author, FRANCISCO M. PERALTA, M.D.Search for more papers by this author, HAROLD C. LYONS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-545 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of particulate carrier agglutination methods has made possible the serological detection of serum macroglobulins which interact with human or animal gamma globulin (1). These macroglobulins, present with great frequency in the sera of patients with rheumatoid arthritis, have been called "rheumatoid factors" (2-4). Similar macroglobulins are also present in many other disease states, including systemic lupus erythematosus, sarcoidosis, syphilis, and cirrhosis of the liver (5-9).Positive "rheumatoid factor" agglutination tests have also been obtained with sera from some patients with chronic pulmonary tuberculosis (9-11). It was the purpose of this study to determine whether such positive "rheumatoid factor"...References1. ZIFF M: The agglutination reaction in rheumatoid arthritis. J. Chron. Dis. 5: 644, 1957. CrossrefMedlineGoogle Scholar2. FRANKLINHOLMANMULLER-EBERHARDKUNKEL ECHRHJHG: An unusual protein component of high molecular weight in the serum of certain patients with rheumatoid arthritis. J. Exp. Med. 105: 425, 1957. CrossrefMedlineGoogle Scholar3. LOSPALLUTOZIFF JM: Chromatographic studies of the rheumatoid factor. J. Exp. 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Google Scholar26. SCHAFFNERTURNERESHBAUGHBUCKINGHAMPOPPER FGCDEWBH: Hypergammaglobulinemia in pulmonary tuberculosis. Arch. Intern. Med. 92: 490, 1953. CrossrefGoogle Scholar27. KORNKELLOWHELLERCHOMETZIMMERMAN RJWFPBHJ: Hepatic involvement in extrapulmonary tuberculosis. Histologic and functional characteristics. Amer. J. Med. 28: 60, 1959. CrossrefGoogle Scholar28. EPSTEINENGLEMANROSS WVEPM: Quantitative studies of the precipitation and agglutination reactions between serum of patient with "connective tissue" disease and a preparation (Cohn Fraction II) of human gamma globulin. J. Immunol. 79: 441, 1957. MedlineGoogle Scholar29. VAUGHANELLISMARSHALL JHPJH: Quantitative considerations of the rheumatoid factor. J. Immunol. 81: 261, 1958. MedlineGoogle Scholar30. TOMASIFUDENBERGFINBY TBHN: Possible relationship of rheumatoid factors and pulmonary disease. (Abstract) Annual Meeting, Amer. Rheum. Ass. June 22-23, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Department of Medicine, State University College of Medicine, Downstate Medical Center, Brooklyn, New York, and the Departments of Medicine and Microbiology, The Mount Sinai Hospital, New York, New York.Aided in part by grants from the National Foundation and the New York State Chapter of the Arthritis and Rheumatism Foundation.Requests for reprints should be addressed to Jacques M. Singer, M.D., Department of Bacteriology, Montefiore Hospital, 210th Street and Bainbridge Avenue, New York 67, New York. 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SMYTH, M.D. F.A.C.P.Über Anti-Gamma-Globulinfaktoren bei LebererkrankungenVerlaufsdokumentation der TuberkuloseRHEUMATOID FACTOR IN SERUM OF INDIVIDUALS EXPOSED TO ASBESTOSSerologic factors in idiopathic diffuse interstitial pulmonary fibrosisrheumatoid factors in primary and reactive macroglobulinaemia.The occurrence of rheumatoid factor in association with antibody response to influenza A2 (Asian) virusStandardization of the sheep cell agglutination test the use of pooled reference sera and hemagglutination traysDie immunologische Spezifit�t der Rheumafaktoren der prim�r-chronischen PolyarthritisDie Reaktion von Rheumafaktoren mit humanem und tierischem ?-GlobulinLatex Fixation Tests in SarcoidosisThe rheumatoid factorsAnti-gamma globulin factors in liver disease 1 April 1962Volume 56, Issue 4Page: 545-552KeywordsGlobulinsHospital medicineParticulatesRabbitsRheumatoid arthritisSarcoidosisSurgerySyphilisSystemic lupus erythematosusUltracentrifugation ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...