tbuckley/cabot-search huggingface dataset:
P111 Bronchoalveolar Lavage does not affect the Acute Inflammatory Response Following Bronchoscopy and Mediastinoscopy
Authors: RO Jones, JT Murchison, G Casali, EJ Simon, N Anderson, AJ Simpson, WS Walker
Journal: Thorax (2012)

<h3>Objective</h3> Bronchoalveolar lavage (BAL) may be used to investigate acute inflammation following thoracic surgery. However, BAL has previously been found to induce an acute phase response in healthy and critically-ill patients complicating research analysis (1,2). We sought to examine the impact of BAL in thoracic surgery patients hypothesising that BAL would not lead to a significant additional acute inflammatory response. <h3>Methods</h3> Seventeen patients undergoing lung cancer staging bronchoscopy and mediastinoscopy were randomly assigned to have 220mls 0.9% NaCl BAL before surgery (n=10) or no BAL (n=7). Blood samples were taken pre-operatively followed by 6 and 24 hours post-operatively. Exhaled nitric oxide (eNO) was also measured at a flow rate of 50mls/sec at these times. All patients had a CXR at 24hrs and were evaluated for evidence of SIRS using pre-defined criteria. <h3>Results</h3> IL-6 and CRP increased post-operatively peaking at 6hrs and 24hrs respectively however there was no statistically significant difference between the increase for BAL and non-BAL patients (p&gt;0.05). There was no significant increase or variation between the groups for IL-2, IL-4, IL-10, TNF-α or IFN-γ (p&gt;0.05). eNO tended to decrease in the BAL group and increase in the non-BAL group at 6hrs although there was no significant difference between the groups (p=0.167). Post-operative CXR atelectasis developed in 3 patients (2 BAL). One patient in each group developed SIRS. <h3>Conclusion</h3> BAL has minimal impact on acute inflammation following bronchoscopy and mediastinoscopy. It may therefore be used to safely and reliably obtain samples for research or microbiology purposes in thoracic surgery patients. Huang Y-C T, Bassett MA, Levin D, Montilla, Ghio AJ. Acute Phase Reaction in Healthy Volunteers After Bronchoscopy with Lavage. Chest 2006; 129 (6): 1565–9. Terashima T, Amakawa K, Matsumaru A et al. BAL Induces an Increase in Peripheral Blood Neutrophils and Cytokine Levels in Healthy Volunteers and Patients with Pneumonia. Chest 2001; 119 (6): 1724–1729.
ZASP1-D117N ON Z-LINE DECREASES HNAV1.5 FUNCTION IN A DCM SUBJECT WITH CONDUCTION DISTURBANCES
Authors: Yutao Xi, Tomohiko AI, Zhaohui Li, Geru Wu, Enkhsaikhan Purevjav, Shahrzad Abbasi, Jie Cheng, Matteo Vatta
Journal: Journal of the American College of Cardiology (2010)
Bombs in the sexual health war
Authors: D. Spence
Journal: BMJ (2008)

Everyone ducked, but I was too slow, and water splashed into my face. The spermicide made my eyes smart. In the early 1980s we used condoms mainly as water bombs. Sex was taboo at school. Even at medical school we wore balaclavas to our “clap clinic” rotations and never sat down on the toilet seats. Sexual health clinics were in prefabricated huts hidden behind the bin areas of most hospitals. Genitourinary medicine (GUM) consultants had side partings, and junior doctors …
Technetium-99m MDP Uptake in Chronic Venous Insufficiency
Authors: LYNN M. LUCAS-FEHM, P TODD MAKLER, BERNARD SHAPIRO
Journal: Clinical Nuclear Medicine (1986)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Online First Collections ACNM MeetingsCMECommunication in OrganizationCOVID-19Feedback and RewardsFrom the American College of Nuclear MedicineHighly Cited and Frequently Read ArticlesPlanning and Conducting Meetings EffectivelyQuality and Safety in Health CareRecruitment of New PhysiciansTips for Giving a Memorable PresentationTips for LeadersTips for Physicians in Getting the Right Job ACNM ArticlesACNM Website For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Ultraviolet radiation-induced histopathological changes in the skin of the marsupial Monodelphis domestica. I. The effects of acute and chronic exposures and of photoreactivation treatment
Authors: L.A. APPLEGATE, T.D. STUART, R.D. LEY
Journal: British Journal of Dermatology (1985)

Journal Article Ultraviolet radiation‐induced histopathological changes in the skin of the marsupial Monodelphis domestica. I. The effects of acute and chronic exposures and of photoreactivation treatment Get access L.A. APPLEGATE, L.A. APPLEGATE Research Division, Lovelace Medical Foundation, 5400 Gibson Boulevard, SE, Albuquerque, NM 87108, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar T.D. STUART, T.D. STUART Pathology Department, Lovelace Medical Foundation, 5400 Gibson Boulevard, SE, Albuquerque, NM 87108, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar R.D. LEY R.D. LEY Research Division, Lovelace Medical Foundation, 5400 Gibson Boulevard, SE, Albuquerque, NM 87108, U.S.A. Dr Ronald D. Ley. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue 2, 1 August 1985, Pages 219–227, https://doi.org/10.1111/j.1365-2133.1985.tb02068.x Published: 01 August 1985 Article history Accepted: 04 January 1985 Published: 01 August 1985
A CASE OF TYPHOID FEVER TREATED WITH SALOL,—WITH REMARKS.
Authors: R. H. DAY
Journal: JAMA (1889)

Willie Thomas, colored, æt. 17 years, was taken sick on Monday, October 22, 1888, was brought home on Friday, the 26th, and on Monday morning, the 29th, I was called to see him. The following conditions were noted: Skin hot, dry and pungent, pulse 110, temperature 102.4° F., respiration not counted. Tongue red, parched and deeply fissured, with sordes collected upon front teeth and lips, low muttering delirium, urine scanty and high colored, stools not very frequent, but small, watery, and offensive; abdomen slightly tympanitic and sore upon pressure. This boy, residing in Baton Rouge, had gone to work on a sugar plantation, necessitating hard work, loss of rest, rough living, and considerable exposure; and a week of cool rainy weather during the time greatly intensified these unsanitary conditions. This sickness was ushered in with a slight chill, succeeded by high fever, which was said to have been continuous up
Distribution of blood flow between embryo and vitelline bed in the stage 18, 21 and 24 chick embryo
Authors: N. Hu, T. D. Ngo, E. B. Clark
Journal: Cardiovascular Research (1996)

We defined the distribution of blood flow between the embryo and the extraembryonic vascular bed as an initial step in understanding the control of flow distribution in the early developing heart.Dorsal aortic blood flow of stage 18, 21, and 24 chick embryo (n > or = 7 at each stage) was measured with a 20 MHz pulsed-Doppler velocity meter. Analog waveforms were digitally sampled at 500 Hz. 1-5 x 10(3) yellow microspheres in saline suspension were injected into the vitelline vein. The embryo and the extraembryonic vascular bed were harvested and separated from each other. The dye on the microspheres from each portion was extracted and extrapolated from the standard curve of the absorbance of dye concentrations per number of microspheres quantified by spectrophotometry. Blood flow was calculated from the integral of blood velocity and aortic cross-sectional area multiplied by the fraction distribution of microspheres in the embryo and extraembryonic vascular bed. Data were presented as mean +/- standard error of the mean.The proportion distribution of microspheres between embryo and extraembryonic vascular bed shifted from 18.7 +/- 2.5 vs. 81.3 +/- 2.5% at stage 18, 25.1 +/- 3.0 vs. 74.9 +/- 3.0% at stage 21, and 34.2 +/- 2.4 vs. 65.8 +/- 2.4% at stage 24. Indices of blood flow normalized to wet weight (mean +/- 95% confidence interval) were similar between the embryo and the extraembryonic vascular bed, but increased throughout the stages.During embryogenesis, blood flow per unit mass is evenly distributed between the metabolically active embryo and the extraembryonic vascular bed.
Histology of Burkitt's lymphoma.
Authors: S McClatchie
Journal: BMJ (1971)

in which Dr. Linus Pauling's book Vitamin C and the Common Cold' was discussed.During the past six years a programme of research has been carried out in this department on various aspects of the metabolism and action of vitamin C, and several papers have now been published describing the results.27Included in this programme has been a study on the relationship between the administration of supplementary vitamin C and the occurrence of symptoms of the -common cold.Dr. Pauling referred to the results of these investigations in his book.Any discussion about vitamin C and the common cold must take into account the human requirements for exogenous vitamin C. The United Kingdom Panel on Recommended Allowances of Nutrients points out that there are two theories about the human
The Future of Medical Journals: In Commemoration of 150 years of the British Medical Journal
Authors: David W. Sharp
Journal: JAMA (1992)

Leeds Castle, like Sheffield Park, is a trap set by the English Tourist Board more than 200 miles away from the northern industrial city it seems to belong to. Happily, a distinguished band of medical editors met with no difficulty in seeking out its moated beauty during the celebrations in 1990 of one and a half centuries of publication of the British Medical Journal .  Any discussion of the future of medical publications has to take into account the possibility of a paper-free world. In that world—depressing or bright depending on where you look at it from— the bound journal gradually disappears. Doctors, already used to getting their patients' records by calling them up from computer to screen, will, by pressing a key or twitching a mouse, move to an inquiry mode for information that used to appear on the printed page.  At first sight, the 16 contributions to the Leeds
GlaxoSmithKline faces US lawsuit over concealment of trial results
Authors: Owen Dyer
Journal: BMJ (2004)

The British pharmaceutical giant GlaxoSmithKline (GSK) is facing a major lawsuit in the United States over alleged concealment of negative trial results involving its antidepressant paroxetine (marketed there as Paxil and in Britain as Seroxat).

The civil suit, filed by New York state's attorney general, Eliot Spitzer, charges the drug company with “repeated and persistent fraud” in concealing the results of studies that suggested that paroxetine was ineffective in treating depression in adolescents. It is the first time a US public authority has pursued a drug company for misreporting trial data.

Five studies have attracted particular attention. Two of these showed no …
BALDNESS AND CALCIFICATION OF THE "IVORY DOME"
Authors: Frederick Hoelzel
Journal: JAMA (1942)

<h3>To the Editor:—</h3> Some questions concerning baldness which were raised by Dr. Ballenger's comments inThe Journal, June 27, may be answered by observations which I made while serving as technician in gross anatomy at the College of Medicine of the University of Illinois (1916-1917). I then had occasion to remove the brains of about 80 cadavers for separate use in the neurology classes and incidentally noted a seemingly obvious relation between the blood (vessel) supply to the scalp and the quantity of hair. Baldness occurred in persons in whom calcification of the skull bones apparently had not only firmly knitted the cranial sutures but also closed or narrowed various small foramens through which blood vessels pass, most prominently in persons with a luxuriant crop of hair. These blood vessels are mainly veins which normally communicate with the diploic veins in the spongy tissue of the skull bones but which
Hundreds of thousands of pounds of NHS funds have been spent on care of private patients with PIP implants
Authors: I. Torjesen
Journal: BMJ (2012)

Almost 3000 women who had breast augmentation surgery done privately with implants made by the discredited French manufacturer Poly Implant Prosthese (PIP) have been seen by the NHS, more than a third have been investigated, and a small group of women have already had the implants removed, figures from the Department of Health for England show.

The British Association of Aesthetic Plastic Surgeons estimates that the NHS has already spent hundreds of thousands of pounds seeing and treating private patients who had come forward, who represent only a small proportion of the number of women who have received these implants privately. The association has accused private clinics of failing in their “moral obligation” and “ethical duty” to treat patients.

The health department figures show that 2860 women who had their implant surgery done privately have been referred to NHS specialists by their GPs. More than 1100 of these women have undergone scans, 67 women have decided to have their PIP implants removed, and 12 of these procedures have been carried out so far.

But these figures could escalate substantially because only …
Pulmonary Dendritic Cells
Authors: Karim Vermaelen, Romain Pauwels
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Dendritic cells (DCs) are leukocytes that are emerging as chief orchestrators of immune responses. The crucial task of DCs is the continuous surveillance of antigen-exposed sites throughout the body, and their unique responsibility is to decide whether to present sampled antigen in an immunogenic or tolerogenic way. Any misstep can either lead to a flawed immune defense or to allergy, even autoimmunity. It comes as no surprise that the lungs become increasingly the subject of DC-related investigations, as they represent a vast interface between the body and the outer world. This constitutes an enormous challenge for the immune system: "firing up" immune responses inappropriately could have devastating results for the fragile gas exchange structures. Evidence accumulates that DCs play a pivotal role in maintaining the delicate balance between tolerance and active immune response in our respiratory system. The exponentially growing body of DC-related publications is a big challenge. This article aims to provide researchers and clinicians with an up-to-date view on DC biology and its relevance to pulmonary medicine. A developing trend in the field of DCs is the shift from fundamental immunologic research toward exciting clinical insights and applications. For the pulmonary clinician, this heralds the dawn of promising therapies in various domains such as infections, allergy, and cancer.
Report of some Cases of Stoppage of Respiration During Chloroform Anaesthesia Treated by Tracheotomy: With the Report of One Fatal Case of Chloroform Anaesthesia
Authors: A. Maclennan
Journal: BMJ (1896)

TRACHEOTOMY IN CHLOROFORM ANESTHESIA. [NoV.21, i869.whether the series given has been a specially favoured one, and whether cases may occur of a still more severe type, upon which no impression can be made by medical treat- ment.Upon all these points, as well as upon the question as to the method and details of the treatment, this paper aims at eliciting valuable information which may be avail- able, though not yet recorded.It may also be of some use in pointing out that it is desirable, in every case proposed for operation, to inquire closely, not only whether medical treat- ment has been applied, but in what form.
Adrenomedullin Enhances Angiogenic Potency of Bone Marrow Transplantation in a Rat Model of Hindlimb Ischemia
Authors: Takashi Iwase, Noritoshi Nagaya, Takafumi Fujii, Takefumi Itoh, Hatsue Ishibashi-Ueda, Masakazu Yamagishi, Kunio Miyatake, Toshio Matsumoto, Soichiro Kitamura, Kenji Kangawa
Journal: Circulation (2005)

Previous studies have shown that adrenomedullin (AM) inhibits vascular endothelial cell apoptosis and induces angiogenesis. We investigated whether AM enhances bone marrow cell-induced angiogenesis.Immediately after hindlimb ischemia was created, rats were randomized to receive AM infusion plus bone marrow-derived mononuclear cell (MNC) transplantation (AM+MNC group), AM infusion alone (AM group), MNC transplantation alone (MNC group), or vehicle infusion (control group). The laser Doppler perfusion index was significantly higher in the AM and MNC groups than in the control group (0.74+/-0.11 and 0.69+/-0.07 versus 0.59+/-0.07, respectively, P<0.01), which suggests the angiogenic potency of AM and MNC. Importantly, improvement in blood perfusion was marked in the AM+MNC group (0.84+/-0.08). Capillary density was highest in the AM+MNC group, followed by the AM and MNC groups. In vitro, AM inhibited MNC apoptosis, promoted MNC adhesiveness to a human umbilical vein endothelial cell monolayer, and increased the number of MNC-derived endothelial progenitor cells. In vivo, AM administration not only enhanced the differentiation of MNC into endothelial cells but also produced mature vessels that included smooth muscle cells.A combination of AM infusion and MNC transplantation caused significantly greater improvement in hindlimb ischemia than MNC transplantation alone. This effect may be mediated in part by the angiogenic potency of AM itself and the beneficial effects of AM on the survival, adhesion, and differentiation of transplanted MNCs.
Clinical implications of FLT3 mutations in pediatric AML
Authors: S. Meshinchi, T. A. Alonzo, D. L. Stirewalt, M. Zwaan, M. Zimmerman, D. Reinhardt, G. J. L. Kaspers, N. A. Heerema, R. Gerbing, B. J. Lange, J. P. Radich
Journal: Blood (2006)
Evidence for aberrant regulation of the p21Ras pathway in PBMCs of patients with chronic idiopathic urticaria
Authors: Ronit Confino-Cohen, Dorit Aharoni, Arnon Goldberg, Irena Gurevitch, Andreas Buchs, Mordechai Weiss, Joshua Weissgarten, Micha J. Rapoport
Journal: Journal of Allergy and Clinical Immunology (2002)
A Classification of Anemia Based on Functional Activity of the Erythroid Marrow.
Authors: Donald D. Funk
Journal: Annals of Internal Medicine (1966)

s1 May 1966A Classification of Anemia Based on Functional Activity of the Erythroid Marrow.Donald D. Funk, M.D., Clement A. Finch, M.D.Donald D. Funk, M.D.Search for more papers by this author, Clement A. Finch, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1163_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptErythroid marrow function has been evaluated in a variety of hematologic disorders by ferrokinetic measurements including plasma iron turnover rate, red cell utilization, marrow transit time, and body scanning.Comparison of hepatic, splenic, and sacral uptake of plasma sound radioiron-59 with plasma radioiron-59 disappearance demonstrates that only marrow and liver are capable of removing iron directly from transferrin. Parenchymal iron loading is indicated by primary liver uptake of activity. Myeloid metaplasia is detected by initial uptake by spleen and differs from early red cell destruction and splenic sequestration by the timing of tissue activity accumulation. Plasma activity localizes in marrow... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1163-1163KeywordsAnemiaBlood plasmaBone marrowLiverPlasma cellsSpleen Issue Published: 1 May 1966 PDF DownloadLoading ...
Problems of Antenatal Care in the Tropics
Authors: R. R. Trussell
Journal: BMJ (1967)

IBrr 113 that there is a good case for the nutritional origin of these megaloblastic anaemias.The high incidence of pregnancy megaloblastic anaemias in our district, 272 over the same 71-month period, would also support the mainly dietary origin of folate deficiency megaloblastic anaemias.While in some areas it holds true that per- nicious anaemia is the predominant megalo- blastic anaemia in the elderly, this does not appear to be the case in our patient material.This does not subtract from the import- ance of the recommendation contained in the last sentence of your leading article, but underlines at the same time the necessity of an exact diagnosis of the deficiency involved in megaloblastic anaemia in any age groupeven in the elderly.-Weare, etc.,
Back, neck, and shoulder pain in Finnish adolescents: national cross sectional surveys
Authors: Paula Hakala, Arja Rimpelä, Jouko J Salminen, Suvi M Virtanen, Matti Rimpelä
Journal: BMJ (2002)

To study changes in pain of the back and neck in adolescents between 1985 and 2001 and pain of the neck, shoulder, and lower back between 1991 and 2001.Biennial nationwide postal surveys, 1985-2001, and annual classroom surveys, 1996-2001.Finland.62 677 12, 14, 16, and 18 year olds and 127 217 14-16 year olds.Pain in the back and neck, neck and shoulder, or lower back, at least weekly.Prevalence of pain in the back and neck was greater in the 1990s than in the 1980s and increased steadily from 1993 to 1997. Pain of the neck and shoulder and pain of the lower back was much more common in 1999 than in 1991 and in 2001 than in 1999. Pain was more common among girls and older groups: pain of the neck and shoulder affected 24% of girls and 12% of boys in 14 year olds, 38% of girls and 16% of boys in 16 year olds, and 45% of girls and 19% of boys in 18 year olds; pain in the lower back affected 8% of girls and 7% of boys in 14 year olds, 14% of girls and 11% of boys in 16 year olds, and 17% of boys and 13% of girls in 18 year olds.Pain in the neck, shoulder, and lower back is becoming more common in Finnish adolescents. This pain suggests a new disease burden of degenerative musculoskeletal disorders in future adults.
Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers
Authors: Mengyao Zheng, Damiano Librizzi, Ayşe Kılıç, Yu Liu, Harald Renz, Olivia M. Merkel, Thomas Kissel
Journal: Biomaterials (2012)
932-87 Non-Mechanical Energy Expenditure is Preserved During the Transition from Compensatory Hypertrophy to Failure of the Left Ventricle in Dahl Salt-Sensitive Rats
Authors: Isao Morii, Yasuki Kihara, Moriaki Inoko, Masashi Kambayashi, Shigetake Sasayama
Journal: Journal of the American College of Cardiology (1995)
Human Tumor Antigens
Authors: Ingegerd Hellström, Karl Erik Hellström
Journal: New England Journal of Medicine (1971)

Tumor immunology is one of the branches of cancer research to which our hopes go for an ultimate prevention and cure of at least certain tumors. Its history is long and not always illustrious: already, in the beginning of this century, claims were raised that tumors are antigenically different from normal tissues, but it was not until some 15 or 20 years ago that valid evidence for the existence of tumor-associated (specific) antigens was obtained. Most of this evidence has come from work on animal neoplasms. Today, it is a more or less accepted fact that the majority of tumors . . .