tbuckley/cabot-search huggingface dataset:
"Anaerobic" Growth of Gonococci, and Candle Jars
Authors: Reuben D. Wende
Journal: JAMA (1972)

<h3>To the Editor.—</h3> We wish to correct an inaccuracy that appeared in an article recently published inThe Journal(219:1730, 1972). In the first paragraph of the section entitled "Comment" the authors cited among the criteria used for identification of<i>Neisseria gonorrhoeae</i>"growth of the organism anaerobically under increased carbon dioxide tension."<sup>1</sup>This statement is not correct. The organism grows optimally under aerobic conditions,<sup>2</sup>although growth of most strains is enhanced by an increased tension of CO<sub>2</sub>, particularly when strains are cultured from specimens taken directly from patients.<sup>3</sup>In our experience, gonococci grow poorly, if at all, under anaerobic conditions. This misconception concerning atmospheric conditions for growth of<i>N gonorrhoeae</i>is not unique. Another recent article referred to incubation of cultures anaerobically.<sup>4</sup>Since precise conditions for incubation were not described, we cannot evaluate the authors' procedures. We suspect that cultures were incubated in a candle
COMBINED USE OF LIVING VIRUS AND IMMUNE SERUM FOR IMMUNIZATION AGAINST VIRUS INFECTIONS
Authors: G. M. Findlay, E. Hindle
Journal: BMJ (1931)

IMMUNIZATION AGAINST VIRUS INFECTIONS[ MEDICAL OURNAL than for the information it conveys, for not infrequently ulnion is firm-to clinical tests some weeks before it is confirmed radiologically.This third x-ray depicts the anatomical result, but nothing less than a film will-disclose the restoration of function, and even this does not record the various aches and pains which may impair a perfect result.It is strange that public opinion on the treatment of fractures is that anything short of perfection indicates in- competence or negligence, and yet a much greater margin of error is given to us in the treatment of almost any disease.But most of the latter tend to get well, and in some fractures, particularly if occurnng after middle life, we cannot anticipate more than a fair result.
The ERJ in its 21st year of age: a smooth transition for an everlasting evolution
Authors: A. T. Dinh-Xuan, V. Brusasco
Journal: European Respiratory Journal (2008)

Starting a new job has never been an easy task. It is even more difficult to continue an enterprise initiated 20 yrs ago 1, which has then been progressively built upon throughout the years by previous Editorial Boards 2–7, and finally strengthened in such a masterful manner by our predecessors 8. But the advantage of having such a strong heritage is that it offers abundant resources 9, for which we are most grateful to the previous joint European Respiratory Journal ( ERJ ) Chief Editors, Peter J. Sterk and Klaus F. Rabe. By firmly establishing the ERJ among the top journals in the respiratory field 8, 9, they have clearly indicated the way for us, and the new Editorial team, to drive the ERJ forward and provide a constantly improving service for the international respiratory community. Before commencing on this journey, which we will continue for the next 4 yrs, let us have a look back at the paths that have led the ERJ to reach its …
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Authors: Dmitry Usoskin, Alessandro Furlan, Saiful Islam, Hind Abdo, Peter Lönnerberg, Daohua Lou, Jens Hjerling-Leffler, Jesper Haeggström, Olga Kharchenko, Peter V Kharchenko, Sten Linnarsson, Patrik Ernfors
Journal: Nature Neuroscience (2014)
Low Recurrence of Angina Pectoris After Coronary Artery Bypass Graft Surgery With Bilateral Internal Thoracic and Right Gastroepiploic Arteries
Authors: T. Margot Bergsma, Jan G. Grandjean, Adriaan A. Voors, Piet W. Boonstra, Peter den Heyer, Tjark Ebels
Journal: Circulation (1998)

Background —In the past 10 years, there has been a trend to use more arterial grafts instead of vein grafts for coronary artery bypass graft surgery. Although there are many reports on the short- and mid-term follow-up of patients who underwent arterial revascularization with 1 or 2 arteries, little has been reported on the follow-up of patients with 3-vessel disease who received 3 arteries. Methods and Results —We reviewed a group of 256 patients with 3-vessel disease who received the right gastroepiploic artery together with both internal thoracic arteries (ITAs). Vein grafts were not used in these patients. The patients were monitored for up to 7 years (mean, 51±15 months). Seven-year actuarial survival was 91.1%. The cumulative probability of event-free survival for myocardial infarction, reintervention, and angina pectoris at 7 years was 97.3%, 95.4%, and 85.4%, respectively. Conclusions —We conclude that concomitant use of the gastroepiploic artery with both ITAs results in low mortality and a low incidence of myocardial infarction and reintervention at follow-up. Most interestingly, we found 85.4% freedom from angina pectoris after 7 years, which is considerably lower than the results of studies in which vein grafts, single ITA grafts, or double ITA grafts are used. These results strongly support the use of both ITAs and the right gastroepiploic artery for bypass grafting in patients with 3-vessel disease.
Impulse Oscillation Technique May Help to Better Discriminate Between Asthmatic Preschool Children and Healthy Controls When Combined with Conventional Spirometry on The Basis of Their Bronchodilator Response
Authors: Y.H. Shin, H.M. Jee, D.W. Jung, S.H. Choi, H.Y. Yum, M.Y. Han
Journal: Journal of Allergy and Clinical Immunology (2011)
N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus
Authors: Corinna M. Bremer, Irina Sominskaya, Dace Skrastina, Paul Pumpens, Ahmed Abd El Wahed, Ulrike Beutling, Ronald Frank, Hans-Joachim Fritz, Gerhard Hunsmann, Wolfram H. Gerlich, Dieter Glebe
Journal: Journal of Hepatology (2010)
A case of fatal ephedra intake associated with lipofuscin accumulation, caspase activation and cleavage of myofibrillary proteins
Authors: Carol Chen‐Scarabelli, Siân E. Hughes, Giorgio Landon, Peter Rowley, Zuhair Allebban, Noel Lawson, Louis Saravolatz, Julius Gardin, David Latchman, Tiziano M. Scarabelli
Journal: European Journal of Heart Failure (2005)
Laparoscopic Resection for Colon Cancer — The End of the Beginning?
Authors: Theodore N. Pappas, Danny O. Jacobs
Journal: New England Journal of Medicine (2004)

Technological advances, which are followed by long periods of catch-up while clinicians learn how to use the new techniques appropriately, often precede true medical progress. Such certainly appears to be the case for minimally invasive surgery. Early on, surgeons were hampered by having to steady the laparoscope with one hand and look through a small lens while performing surgery with the other hand. Advances in laparoscopic surgery were facilitated by a series of innovations that allowed true video surgery, in which two surgeons work together with both hands to perform operations. In the late 1990s, surgeons began to use minimally . . .
TranscriptSNPView: a genome-wide catalog of mouse coding variation
Authors: Fiona Cunningham, Daniel Rios, Mark Griffiths, James Smith, Zemin Ning, Tony Cox, Paul Flicek, Pablo Marin-Garcin, Javier Herrero, Jane Rogers, Louise van der Weyden, Allan Bradley, Ewan Birney, David J Adams
Journal: Nature Genetics (2006)

Has the chimpanzee Y chromosome
Therapeutic Effects of Human Mesenchymal Stem Cells in <i>Ex Vivo</i> Human Lungs Injured with Live Bacteria
Authors: Jae W. Lee, Anna Krasnodembskaya, David H. McKenna, Yuanlin Song, Jason Abbott, Michael A. Matthay
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Mesenchymal stem cells secrete paracrine factors that can regulate lung permeability and decrease inflammation, making it a potentially attractive therapy for acute lung injury. However, concerns exist whether mesenchymal stem cells' immunomodulatory properties may have detrimental effects if targeted toward infectious causes of lung injury.Therefore, we tested the effect of mesenchymal stem cells on lung fluid balance, acute inflammation, and bacterial clearance.We developed an Escherichia coli pneumonia model in our ex vivo perfused human lung to test the therapeutic effects of mesenchymal stem cells on bacterial-induced acute lung injury.Clinical-grade human mesenchymal stem cells restored alveolar fluid clearance to a normal level, decreased inflammation, and were associated with increased bacterial killing and reduced bacteremia, in part through increased alveolar macrophage phagocytosis and secretion of antimicrobial factors. Keratinocyte growth factor, a soluble factor secreted by mesenchymal stem cells, duplicated most of the antimicrobial effects. In subsequent in vitro studies, we discovered that human monocytes expressed the keratinocyte growth factor receptor, and that keratinocyte growth factor decreased apoptosis of human monocytes through AKT phosphorylation, an effect that increased bacterial clearance. Inhibition of keratinocyte growth factor by a neutralizing antibody reduced the antimicrobial effects of mesenchymal stem cells in the ex vivo perfused human lung and monocytes grown in vitro injured with E. coli bacteria.In E. coli-injured human lungs, mesenchymal stem cells restored alveolar fluid clearance, reduced inflammation, and exerted antimicrobial activity, in part through keratinocyte growth factor secretion.
German doctors criticise "lifestyle pensions" that reward smoking and obesity
Authors: A. Tuffs
Journal: BMJ (2009)

Doctors in Germany have voiced concerns about the introduction of so called lifestyle pensions, which “reward” unhealthy behaviour by offering higher annuities to groups of people, such as smokers and obese people, who may be expected to die earlier than average. 

Rudolf Henke, the chairman of the Marburger Bund, the German hospital doctors’ society, said it was “ludicrous and cynical” to reward customers for risking their own health.

Lifestyle …
Four cases of bromism.
Authors: G. Nuki, P. Richardson, M. J. Goggin, R. I. Bayliss
Journal: BMJ (1966)

Intravenous Diets-Peaston MEDIBALIJOURNAL balance for water.The results in six patients were compared with those obtained during intragastric feeding of the same patients.The intragastric diet of milk powder and glucose maintained metabolic balance except for a negative chloride balance.The urinary total nitrogen, ammonia, and amino- acids were similar on the two diets, but urea excretion was reduced on the intravenous diet, suggesting a decrease in protein catabolism.
Pain in Children: A Practical Guide for Primary Care
Authors: Cleo K. Hardin
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
453. Injectionof Different Adult Cell Types into Mouse Myocardium Three Days after Myocardial Infarction Using a Novel Echo-Guided Technique Improves Cardiac Function
Authors: Yan Zhang, Junya Takagawa, Richard E. Sievers, Maelene L. Wong, Christian Heiss, Mohan N. Viswanathan, Neel K. Kapasi, Jianqin Ye, Elyse Foster, William Grossman, Matthew L. Springer, Yerem Yeghiazarians
Journal: Molecular Therapy (2006)

Objective: Myocardial regeneration based on stem cell transplantation has emerged as a potential therapeutic approach toward replacing myocardial scar with functioning contractile tissue after myocardial infarction (MI). Considerable interest has focused on bone marrow cells (BMCs) and endothelial progenitor cells (EPCs) because they appear successful in attenuating remodeling following acute MI. However, preclinical experiments toward this goal have been limited to treatment within hours of an MI, in contrast to human trials, in which cell treatment has been performed several days later after patient stabilization and autologous cell harvesting.
Treatment of ocular hypertension and open angle glaucoma: meta-analysis of randomised controlled trials
Authors: Philip C Maier, Jens Funk, Guido Schwarzer, Gerd Antes, Yngve T Falck-Ytter
Journal: BMJ (2005)

<h3>Abstract</h3> <b>Objective</b> Open angle glaucoma is one of the most common causes of blindness in industrialised nations. Treatments to lower ocular pressure are widely used in glaucoma prevention and treatment, despite conflicting evidence. <b>Design</b> We performed meta-analyses to reassess the effectiveness of pressure lowering treatment to delay the development of glaucoma in ocular hypertension, as well as progression of manifest open angle glaucoma. <b>Data sources</b> Medline, Embase, and the Cochrane Library. <b>Selection of studies</b> Eligible studies were randomised controlled trials with a concurrent untreated control group and information on time to glaucomatous changes to visual field and optic disc. Trial reports were reviewed independently by two investigators in an unblinded standardised manner. <b>Results</b> Meta-analysis of trials in ocular hypertension showed a significant preventive effect of reducing intraocular pressure on progression to glaucoma (hazard ratio 0.56, 95% confidence interval 0.39 to 0.81, P = 0.01; number needed to treat 12). Pooled data of studies in manifest glaucoma showed a significant delay of visual field deterioration (0.65, 0.49 to 0.87, P = 0.003; NNT = 7), with subgroup analysis showing a larger effect in patients with raised pressure and a reduced effect in normal tension glaucoma (subgroup comparison: not significant). <b>Conclusions</b> Lowering intraocular pressure in patients with ocular hypertension or manifest glaucoma is beneficial in reducing the risk of visual field loss in the long term.
Comparison of initial detection and redetection of ventricular fibrillation in a transvenous defibrillator system with automatic gain control
Authors: Charles I. Berul, David J. Callans, David S. Schwartzman, Mark W. Preminger, Charles D. Gottlieb, Francis E. Marchlinski
Journal: Journal of the American College of Cardiology (1995)

Objectives. The purpose of this study was to prospectively evaluate postshock redetection of ventricular fibrillation by a system that coupled an implantable cardioverter-defibrillator with an automatic gain control sense amplifier and a transvenous lead system. Background. Redetection of ventricular fibrillation after an unsuccessful first shock has not been systematically evaluated. Previous studies have suggested that sensing performance of some-lead systems may be adversely affecter by the delivery of subthreshold shocks. Methods. The time required for both initial detection and redetection of ventricular fibrillation was compared in 22 patients. These times were estimated by subtracting the capacitor charge time from the total event time. Results. A total of 113 successful and 57 unsuccessful initial shocks were delivered during induced ventricular fibrillation. The mean ± SD initial time to detection of ventricular fibrillation was 5.5 ± 1.7 s (range 2.4 to 10.8); the time to redetection ranged from 1.5 to 18.5 s (mean 4.5 ± 2.8, p = NS vs. detection time). Abnormal redetection episodes, defined as a redetection time >10.2 s (i.e., >2 SD above the mean redetection time), were observed in 4 (18%) of 22 patients. Conclusions. Redetection of ventricular fibrillation after a subthreshold first shock may be delayed. Device testing with intentional delivery of subthreshold shocks to verify successful postshock redetection of ventricular fibrillation should be performed routinely in all patients.
Abstract P1-01-14: Extracorporeal shock wave therapy for lymphedema after axillary lymphadenectomy
Authors: S Imboden, D Herzig, M Rabaglio, R Hohermuth, MD Mueller, AR Günthert, P Eser, J-P Schmid
Journal: Cancer Research (2013)

Abstract Introduction: Lymphedema is a frequent complication of local treatment for breast cancer. Substantial differences in the incidence of lymphedema have been reported depending on the extent of surgery, presence of lymph node metastasis and postoperative radiotherapy. The classical treatment of lymphedema includes manual lymph drainage and compressive bandages. No pharmacological treatment has been shown to be effective. In animal experiments extracorporeal shock wave therapy (ESWT) has been shown to stimulate angiogenesis and lymphatic vessel regeneration. However, whether ESWT reduces lymphedema after axillary lymphadenectomy is unknown. Patients and Method: We randomized patients with lymphedema after axillary lymphadenectomy (2004 to 2011) into a treatment and a placebo group. Informed consent was obtained from all patients. All but one patient had at least one positive lymph node. A mean of 21.9 (5-43) lymph nodes were removed. 8/10 had an adjuvant radiotherapy of the axilla. ESWT of the whole edematous limb was performed once a week for 10 weeks (2000 shots, energy density 0,25-0,69 mJ/mm2). The placebo group underwent similar treatment, but the shock waves were absorbed in the probe. At baseline and at the end of treatment a clinical and oncological control was performed, including tolerability of the therapy (pain, local skin changes or infections) and oncological safety (recurrence rate). The response to ESWT was measured by volumetry (water displacement of the whole arm) and peripheral quantitative computed tomography (pQCT, change in total cross sectional area of the most swollen part of the arm). Also questionnaires on subjective body feeling, activity score and body image were applied. Results: We report the preliminary results of the first 10 patients (placebo n = 5, verum n = 5) after 10 weeks. The median change water displacement volume in the verum group corresponded to -192.5 ml (25% percentile: -366.3 ml, 75% percentile -148.8 ml) vs. -12.5 ml (25% percentile: -192.8 ml, 75% percentile: 147.5 ml) in the placebo group (p-value for Mann-Whitney U test: 0.093). Cross sectional area decreased by -3.05% (25% percentile: -8.73%, 75% percentile: 1.49%) in the verum group vs. -1.36% (25% percentile -3.47%, 75% percentile 4.20%) in the placebo group (p-value: 0.394). No treatment had to be interrupted due to local complications. Conclusion: ESWT is well tolerated in patients treated for lymphedema after axillary lymphadenectomy. Our preliminary results show a promising trend towards both objective and subjective improvement of the lymphedema. The statistical significance of these improvements has to be confirmed after inclusion of all patients (N = 30). Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-01-14.
Aesthetic Plastic Surgery
Authors: Joseph E. Murray
Journal: JAMA (1981)

<b>Aesthetic Plastic Surgery,</b>by Richard B. Stark, 530 pp, with illus, $55, Boston, Little Brown &amp; Co, 1980. Rees' credibility and experience sparkle throughout his<i>Aesthetic Plastic Surgery</i>, two attractively bound and clearly illustrated volumes. He includes "basic practical tested surgical maneuvers that have withstood the test of time" and he includes technical advances since 1973 when his previous text,<i>Cosmetic Facial Surgery</i>, was published. Substitution of the term "aesthetic" for "cosmetic" in the title apparently reflects a preferred direction in current society. The introductory chapter "Concepts of Beauty" whets the reader's appetite. The chapter "Selection of Patients" contains gems on how to avoid complications and dissatisfaction: "The hardest but most important lesson for the young surgeon to learn is how to recognize which patients seeking cosmetic surgery will become postoperative problems." The rest of the first volume deals with the nose: anatomy, physiology, techniques of rhinoplasty, and complications, all
Genetic variation in phospholipid transfer protein modulates lipoprotein profiles in hyperalphalipoproteinemia
Authors: Mary B. Engler, Clive R. Pullinger, Mary J. Malloy, Yanina Natanzon, Medha V. Kulkarni, James Song, Celeste Eng, Jaarko Huuskonen, Christopher Rivera, Annie Poon, Matt Bensley, Amy Sehnert, Christian Zellner, John Kane, Bradley E. Aouizerat
Journal: Metabolism (2008)
Survival Benefits from Follow-Up of Patients with Lung Cancer: A Systematic Review and Meta-Analysis
Authors: Lynn Calman, Kinta Beaver, Daniel Hind, Paul Lorigan, Chris Roberts, Myfanwy Lloyd-Jones
Journal: Journal of Thoracic Oncology (2011)

The burden of lung cancer is high for patients and carers. Care after treatment may have the potential to impact on this. We reviewed the published literature on follow-up strategies intended to improve survival and quality of life.We systematically reviewed studies comparing follow-up regimes in lung cancer. Primary outcomes were overall survival (comparing more intensive versus less intensive follow-up) and survival comparing symptomatic with asymptomatic recurrence. Quality of life was identified as a secondary outcome measure. Hazard ratios (HRs) and 95% confidence intervals from eligible studies were synthesized.Nine studies that examined the role of more intensive follow-up for patients with lung cancer were included (eight observational studies and one randomized controlled trial). The studies of curative resection included patients with non-small cell lung cancer Stages I to III disease, and studies of palliative treatment follow-up included limited and extensive stage patients with small cell lung cancer. A total of 1669 patients were included in the studies. Follow-up programs were heterogeneous and multifaceted. A nonsignificant trend for intensive follow-up to improve survival was identified, for the curative intent treatment subgroup (HR: 0.83; 95% confidence interval: 0.66-1.05). Asymptomatic recurrence was associated with increased survival, which was statistically significant HR: 0.61 (0.50-0.74) (p < 0.01); quality of life was only assessed in one study.This meta-analysis must be interpreted with caution due to the potential for bias in the included studies: observed benefit may be due to systematic differences in outcomes rather than intervention effects. Some benefit was noted from intensive follow-up strategies. More robust data, in the form of randomized controlled trials, are needed to confirm these findings as the review is based primarily on observational studies. Future research should also include patient-centered outcomes to investigate the impact of follow-up regimes on living with lung cancer and psychosocial well-being.
The effect of glucagon on serum gastrin: I Studies in normal subjects
Authors: J. Hansky, C. Soveny, M. G. Korman
Journal: Gut (1973)

Serum gastrin has been determined by radioimmunoassay in 13 subjects free of gastrointestinal disease, in the basal state, and following the intravenous injection of 1 mg glucagon. Serum gastrin fell from a mean ± SEM level of 50·3 ± 6·7 to 9·4 ± 3·3 pg/ml at 30 minutes after injection, significant at p&lt;0·005. This is similar to the response previously reported for secretin and indicates a role for glucagon in the control of gastrin release.