Somatostatin Treatment for Cryptosporidial Diarrhea in a Patient with the Acquired Immunodeficiency Syndrome (AIDS)
Authors: DEBORAH J. COOK
Journal: Annals of Internal Medicine (1988)

Brief Reports1 May 1988Somatostatin Treatment for Cryptosporidial Diarrhea in a Patient with the Acquired Immunodeficiency Syndrome (AIDS)DEBORAH J. COOK, M.D., JOHN G. KELTON, M.D., ANDRZEJ M. STANISZ, M.D., STEPHEN M. COLLINS, M.D.DEBORAH J. COOK, M.D.Search for more papers by this author, JOHN G. KELTON, M.D.Search for more papers by this author, ANDRZEJ M. STANISZ, M.D.Search for more papers by this author, STEPHEN M. COLLINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-5-708 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn healthy persons, the coccidioidal protozoan, Cryptosporidium, can inhabit the microvillous border of intestinal epithelial cells and cause an acute self-limited diarrhea. In contrast, the protozoan can cause chronic severe secretory diarrhea in immunosuppressed patients ( 1 ).Somatostatin has controlled diarrhea in patients with Zollinger-Ellison syndrome (2), Werner-Morrison syndrome (3-5) and the carcinoid syndrome (6). We administered somatostatin analogue (SMS-201-995,, Sandoz Pharmaceuticals, , , Dorval, Quebec) to a patient with the acquired immunodeficiency syndrome (AIDS) who was colonized with cryptosporidia and had diarrhea that was refractory to conventional medical therapy.A 24-year-old heterosexual man with a congenital bicuspid...References1. PORTNOYWHITESIDEBUCKLEYMCLEOD DMEC. Treatment of intestinal cryptosporidiosis with spiramycin. Ann Intern Med. 1984;101;202-4. LinkGoogle Scholar2. BONFILSRUSZNIEWSKICOSTIL SPV. Prolonged treatment of Zollinger-Ellison syndrome by long-acting somatostatin. Lancet. 1986;1:554-5. CrossrefMedlineGoogle Scholar3. SANTANGELOO'DORISIOKIM WTJ Vipoma syndrome: effect of a synthetic somatostatin analogue. 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Robinson Jr., MD, Ronald Fogel, MD 1 May 1988Volume 108, Issue 5Page: 708-709KeywordsAIDSCryptosporidiumDiarrheaEpithelial cellsHeterosexualsProtozoansSomatostatinZollinger Ellison syndrome Issue Published: 1 May 1988 PDF DownloadLoading ...