tbuckley/cabot-search huggingface dataset:
TCT-669 Very Low Intravenous Contrast Dose (20 cc) Computed Tomographic Angiography Protocol for Pre-Procedural Assessment of the Aortic Annulus Prior to Transcatheter Aortic Valve Replacement: Validation by 3-Dimensional Transesophageal Echocardiography
Authors: Omar K. Khalique, Todd Pulerwitz, Tamim M. Nazif, Martin Leon, Isaac George, Hemal Gada, Torsten P. Vahl
Journal: Journal of the American College of Cardiology (2014)
Hepatorenal Correction in Murine Glycogen Storage Disease Type I With a Double-stranded Adeno-associated Virus Vector
Authors: Xiaoyan Luo, Gentzon Hall, Songtao Li, Andrew Bird, Peter J Lavin, Michelle P Winn, Alex R Kemper, Talmage T Brown, Dwight D Koeberl
Journal: Molecular Therapy (2011)

Glycogen storage disease type Ia (GSD-Ia) is caused by the deficiency of glucose-6-phosphatase (G6Pase). Long-term complications of GSD-Ia include life-threatening hypoglycemia and proteinuria progressing to renal failure. A double-stranded (ds) adeno-associated virus serotype 2 (AAV2) vector encoding human G6Pase was pseudotyped with four serotypes, AAV2, AAV7, AAV8, and AAV9, and we evaluated efficacy in 12-day-old G6pase (-/-) mice. Hypoglycemia during fasting (plasma glucose <100 mg/dl) was prevented for >6 months by the dsAAV2/7, dsAAV2/8, and dsAAV2/9 vectors. Prolonged fasting for 8 hours revealed normalization of blood glucose following dsAAV2/9 vector administration at the higher dose. The glycogen content of kidney was reduced by >65% with both the dsAAV2/7 and dsAAV2/9 vectors, and renal glycogen content was stably reduced between 7 and 12 months of age for the dsAAV2/9 vector-treated mice. Every vector-treated group had significantly reduced glycogen content in the liver, in comparison with untreated G6pase (-/-) mice. G6Pase was expressed in many renal epithelial cells of with the dsAAV2/9 vector for up to 12 months. Albuminuria and renal fibrosis were reduced by the dsAAV2/9 vector. Hepatorenal correction in G6pase (-/-) mice demonstrates the potential of AAV vectors for the correction of inherited diseases of metabolism.
CONSERVATISM IN OVARIOTOMY.
Authors: HOWARD A. KELLY
Journal: JAMA (1896)

I have recently received two vigorous letters, which I enclose, from friends who are doctors, upon the ethical status of the operation for the removal of the ovaries. These letters have brought vividly to mind a note which I published in the American Journal of Obstetrics , for February 1893, entitled The Ethical Side of the Operation of Oophorectomy; I have gone over the ground once more from the standpoint of almost three years' growth in gynecology, to see what positive advances have been made in answer to this burning question. Both of the letters are from highly valued friends, for whose opinions I have a profound respect, and in whose judgment I place full confidence; I feel under obligation to reply to them in such a way as shall effectually promote the end in view. One of the letters, the second one, is from a distinguished physician, the leading practitioner
A `Truth in Mending' Act
Authors: Eben Alexander
Journal: JAMA (1980)

ON JAN 25, 1979, the following two paragraphs appeared in Jonathan Rand's sports column in the<i>Miami Herald</i>: Tom Kite has been named winner of the Bob Jones Award in recognition of an outstanding example of sportsmanship in 1978. It would be tough to argue that anyone deserved it more. Kite penalized himself one stroke for an infraction that no one else saw in the final round of last year's Hall of Fame Classic in Pinehurst, N.C. He finished one stroke behind the winner, Tom Watson. For reasons best known to himself, however, Rand titled the item "Was This Award Really Worth the Price?" Perhaps Rand was merely pondering the influence that monetary gain has on what is considered ethical and honest. It would be nice to believe that most of us in the medical field are the Tom Kites of the world and that we are symbols of honor
FDA is sued for allegedly violating privacy of employees
Authors: B. Roehr
Journal: BMJ (2012)

Six current and former employees of the US Food and Drug Administration (FDA) have sued that agency for allegedly violating their right to privacy by secretly monitoring their personal email activity. The doctors and scientists reviewed medical devices for the agency as part of the approval process.

Among the monitored activity were complaints to congressional staff members about the safety and efficacy of medical devices the agency approved, over objections from the employees.

The employees say they were harassed, terminated, or did not have their contracts as outside consultants renewed because of their …
Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70
Authors: Adeboye H. Adewoye, Elizabeth S. Klings, Harrison W. Farber, Elizabeth Palaima, Maria A. Bausero, Lillian McMahon, Adam Odhiambo, Safaya Surinder, Mark Yoder, Martin H. Steinberg, Alexzander Asea
Journal: American Journal of Hematology (2005)

Inflammation may play an important role in the pathophysiology of sickle cell disease (SCD), and recent studies have identified the 70-kDa heat shock protein (Hsp70) as an important mediator of inflammatory responses. Here we demonstrate a significant increase in circulating serum Hsp70 level in SCD during vaso-occlusive crisis (VOC) as compared with baseline steady-state levels (P < 0.05) and a significant increase in Hsp70 levels in SCD at baseline compared with normal controls (P < 0.05). Taken together, these results indicate that circulating serum Hsp70 might be a marker for VOC in SCD. Am. J. Hematol. 78:240–242, 2005. © 2005 Wiley-Liss, Inc.
Pilot projects for personal health budgets in England are announced
Authors: Z. Kmietowicz
Journal: BMJ (2009)

A total of 75 primary care trusts have been selected to take part in a trial of personal health budgets throughout England.

The pilot projects will assess whether giving patients greater involvement in how money is spent on their healthcare needs will deliver more personalised services, one of the key aims outlined by the health minister Ara Darzi in his review of the NHS, High Quality Care …
POLY(ADP–RIBOSE) POLYMERASE–14 COOPERATES WITH TRISTETRAPROLIN TO CONTROL TISSUE FACTOR MRNA STABILITY: A NOVEL ROLE FOR ADP–RIBOSYLATION IN REGULATING THROMBOSIS
Authors: Bilal Iqbal, Michael Johns, Mark Boothby, Dorian Haskard
Journal: Journal of the American College of Cardiology (2013)
Transplantation of autologous endothelial cells induces angiogenesis in a sheep model of chronic ischemia
Authors: Nicholas N. Kipshidze, Guennady Tchekanov, George Dangas, Roxana Mehran, Fermin Tio, Gary S. Roubin, Milena G. Adamian, Martin B. Leon, Antonio Colombo, Elazer Edelman, Jeffrey W. Moses, Masood Akhtar, Valeri Chekanov
Journal: Journal of the American College of Cardiology (2003)
A systems approach identifies HIPK2 as a key regulator of kidney fibrosis
Authors: Yuanmeng Jin, Krishna Ratnam, Peter Y Chuang, Ying Fan, Yifei Zhong, Yan Dai, Amin R Mazloom, Edward Y Chen, Vivette D'Agati, Huabao Xiong, Michael J Ross, Nan Chen, Avi Ma'ayan, John Cijiang He
Journal: Nature Medicine (2012)
Microbicide offers no protection against HIV infection
Authors: B. Roehr
Journal: BMJ (2009)

There has been another setback in efforts to develop a microbicide to protect women against HIV infection during vaginal sex. Results of a large clinical trial of PRO 2000, released on 14 December, showed that although the product was safe, it was not effective against infection.

The large (9385 women) double blind, placebo controlled trial (called MDP 301) was conducted by the Microbicides Development Programme—a broad international collaboration—in South Africa, Tanzania, Uganda, and Zambia. It had substantial support …
Declining sperm counts
Authors: D M de Kretser
Journal: BMJ (1996)

The controversy over whether sperm counts have declined over the past 50 years is reopened by two papers in this issue of the BMJ. In a carefully analysed study of cohorts of unselected men in Britain born between 1951 and 1973, Irvine and colleagues demonstrate a progressive decline in sperm concentration and total sperm number per ejaculate of about 2% a year over 11 years.1 A smaller study by Bujan et al finds no change in sperm counts of sperm donors in the Toulouse area of France over a 16 year period.2

The controversy over sperm counts began with a metaanalysis by Carlsen et al which showed a decline in a sperm concentrations from 113 x 106/ml to 66 x 106/ml between 1940 and 1990.3 These findings were supported by Auger et al in a study of 1351 fertile men in Paris.4 …
Quantitative Risk Assessment: Biomedical Ethics Reviews—1986
Authors: Robert M. Veatch
Journal: JAMA (1988)

The current issue of<i>Biomedical Ethics Reviews</i>is devoted to one nonclinical topic: quantitative risk assessment (QRA) as used by government agencies and others attempting to quantify the risks associated with environmental and public health practices. It contains papers from a September 1985 conference. The two-part volume first presents four accounts by practicing risk analysts and then five commentaries by philosophers attuned to the ethical, epistemological, and other philosophical questions raised by QRA. The authors are unanimous in one conclusion: risk assessment necessarily involves assumptions, evaluations, or subjective judgments, at least at some point. The practitioners show that countless assumptions necessarily must be made: assumptions about conceptualizing the problem, modeling the risks, choosing the proper animal models, criteria for statistical analysis, methods for extrapolating to low-dose exposure. Inherently evaluative judgments must be made about how serious harms are and even whether they are harms or benefits. These papers provide intriguing
Anthrax Toxin Targeting of Myeloid Cells through the CMG2 Receptor Is Essential for Establishment of Bacillus anthracis Infections in Mice
Authors: Shihui Liu, Sharmina Miller-Randolph, Devorah Crown, Mahtab Moayeri, Inka Sastalla, Shu Okugawa, Stephen H. Leppla
Journal: Cell Host & Microbe (2010)
Molecular Mechanisms of Transforming Growth Factor-β Signaling
Authors: Patrick Pei-chih Hu, Michael B. Datto, Xiao-fan Wang
Journal: Endocrine Reviews (1998)

I. Introduction II. Ligands and Receptors A. Ligands B. Receptors C. Receptor kinase signaling III. Smads A. Cloning of the Smads B. Smad regulation C. Smad nuclear function D. Smad structure E. Smads as negative regulators F. Smad-deficient mice G. Smads: an emerging model IV. TGF-β and the Cell Cycle A. TGF-β induction of the CKIs B. TGF-β-mediated decrease in Cdc25A levels in the breast epithelial cell line MCF10A C. TGF-β-mediated cyclin-CDK inhibition may be common strategy to arrest cells in G1 V. TGF-β and Cancer A. Receptor mutants B. Smad mutants C. Cell cycle mutants D. Multilevel resistance to TGF-β is important in multistep model of carcinogenesis VI. Conclusions
Modulation of Distinct Asthmatic Phenotypes in Mice by Dose-Dependent Inhalation of Microbial Products
Authors: Gregory S. Whitehead, Seddon Y. Thomas, Donald N. Cook
Journal: Environmental Health Perspectives (2013)

Humans with asthma display considerable heterogeneity with regard to T helper (Th) 2-associated eosinophilic and Th17-associated neutrophilic inflammation, but the impact of the environment on these different forms of asthma is poorly understood.We studied the nature and longevity of asthma-like responses triggered by inhalation of allergen together with environmentally relevant doses of inhaled lipopolysaccharide (LPS).Ovalbumin (OVA) was instilled into the airways of mice together with a wide range of LPS doses. Following a single OVA challenge, or multiple challenges, animals were assessed for pulmonary cytokine production, airway inflammation, and airway hyperresponsiveness (AHR).Mice instilled with OVA together with very low doses (≤10⁻³ μg) of LPS displayed modest amounts of Th2 cytokines, with associated airway eosinophilia and AHR after a single challenge, and these responses were sustained after multiple OVA challenges. When the higher but still environmentally relevant dose of 10⁻¹ μg LPS was used, mice initially displayed similar Th2 responses, as well as Th17-associated neutrophilia. After multiple OVA challenges, however, the 10⁻¹ μg LPS animals also accumulated large numbers of allergen-specific T regulatory (Treg) cells with high levels of inducible co-stimulatory molecule (ICOS). As a result, asthma-like features in these mice were shorter-lived than in mice sensitized using lower doses of LPS.The nature and longevity of Th2, Th17, and Treg immune responses to inhaled allergen are dependent on the quantity of LPS inhaled at the time of allergic sensitization. These findings might account in part for the heterogeneity of inflammatory infiltrates seen in lungs of asthmatics.
New Technology, Old Dilemma — Monitoring EEG Activity during Executions
Authors: Robert Steinbrook
Journal: New England Journal of Medicine (2006)

On April 21, 2006, Willie Brown, Jr., was executed by lethal injection in North Carolina for the 1983 killing of a convenience-store clerk. The execution might have received little attention if not for the fact that Brown's electroencephalogram (EEG) was monitored during the procedure. This apparently unprecedented monitoring was a response to concern that some inmates have not been properly anesthetized during executions by lethal injection and may therefore have experienced painful deaths that violated the constitutional ban on cruel and unusual punishment.1,2 The EEG device used during Brown's execution was a bispectral index (BIS) monitor. Made by Aspect . . .
Abstract 5571: Inflammatory response as a novel prognostic parameter in patients with metastatic renal cell carcinoma treated with pazopanib
Authors: Brian M. Lingerfelt, Mikhail Y. Akbashev, Viraj A. Master, Wayne B. Harris
Journal: Cancer Research (2012)

Abstract Over sixty thousand patients were diagnosed with metastatic renal cell carcinoma (mRCC) in 2010, yet no tumor markers have been identified. Standard prognostic systems only measure characteristics at baseline and do not assess the potential benefit of therapeutic intervention. The introduction of receptor tyrosine kinase inhibitors has significantly changed the management of mRCC. Pazopanib, a selective, multi-targeted, receptor tyrosine kinase inhibitor, was approved for mRCC in 2009. The modified Glasgow Prognostic Score (mGPS), a prognostic system based on inflammatory biomarkers (serum C-reactive protein (CRP) and albumin), has been validated in the pre-treatment setting for mRCC treated with surgery or cytokines. In this study, we present data demonstrating the correlation of serial mGPS measurements with objective responses to targeted therapy with pazopanib in patients with mRCC. We conducted a retrospective chart review of patients seen at the Winship Cancer Institute for whom serial CRP and albumin measurements as well as imaging studies were available while taking pazopanib. In these patients we assessed the correlation of pre- and post-treatment mGPS scores to objective responses by imaging. Twenty patients met inclusion criteria. Of these patients, 12 (60%) had progressive disease, and 8 (40%) had clinical benefit response (defined as stable disease, partial response, or complete response) by imaging. An elevated pre-treatment mGPS score had 75% sensitivity (95% confidence interval 35.5%-95.5%; P&amp;lt;0.01) and 83.3% specificity (95% confidence interval 50.9%-97.1%; P&amp;lt;0.01) for disease progression at the end of treatment. On the other hand, an elevated post-treatment mGPS score had 100% sensitivity (95% confidence interval 59.8%-100%; P&amp;lt;0.01) and 100% specificity (95% confidence interval 69.9%-100%; P&amp;lt;0.01) for disease progression at the end of treatment. Although these data require prospective validation, they suggest that serial measurements of serum inflammatory biomarkers may improve the sensitivity and specificity of mGPS for response to therapy. If confirmed, inflammatory response rates based on mGPS may become a valuable and cost effective tool to guide patient care and drug development for mRCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5571. doi:1538-7445.AM2012-5571
Nonsurgical treatment of congenital ichthyosis cicatricial ectropion and eyelid retraction using Restylane hyaluronic acid
Authors: A.S. Litwin, G. Kalantzis, E. Drimtzias, S. Hamada, B. Chang, R. Malhotra
Journal: British Journal of Dermatology (2015)

Journal Article Nonsurgical treatment of congenital ichthyosis cicatricial ectropion and eyelid retraction using Restylane hyaluronic acid Get access A.S. Litwin, A.S. Litwin Corneoplastic Unit Queen Victoria Hospital NHS Trust East Grinstead West Sussex RH19 3DZ U.K Search for other works by this author on: Oxford Academic Google Scholar G. Kalantzis, G. Kalantzis The Leeds Teaching Hospitals NHS Trust St James University Hospital Beckett Street Leeds LS9 7TF U.K Search for other works by this author on: Oxford Academic Google Scholar E. Drimtzias, E. Drimtzias The Leeds Teaching Hospitals NHS Trust St James University Hospital Beckett Street Leeds LS9 7TF U.K Search for other works by this author on: Oxford Academic Google Scholar S. Hamada, S. Hamada Corneoplastic Unit Queen Victoria Hospital NHS Trust East Grinstead West Sussex RH19 3DZ U.K Search for other works by this author on: Oxford Academic Google Scholar B. Chang, B. Chang The Leeds Teaching Hospitals NHS Trust St James University Hospital Beckett Street Leeds LS9 7TF U.K Search for other works by this author on: Oxford Academic Google Scholar R. Malhotra R. Malhotra Corneoplastic Unit Queen Victoria Hospital NHS Trust East Grinstead West Sussex RH19 3DZ U.K Correspondence: Raman Malhotra. E‐mail: raman.malhotra@qvh.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 2, 1 August 2015, Pages 601–603, https://doi.org/10.1111/bjd.13710 Published: 01 August 2015
Single- vs. double-balloon enteroscopy in small-bowel diagnostics: a randomized multicenter trial
Authors: D. Domagk, P. Mensink, H. Aktas, P. Lenz, T. Meister, A. Luegering, H. Ullerich, L. Aabakken, A. Heinecke, W. Domschke, E. Kuipers, M. Bretthauer
Journal: Endoscopy (2011)

Background and study aims: Double-balloon enteroscopy (DBE) is the first choice endoscopic technique for small-bowel visualization. However, preparation and handling of the double-balloon enteroscope is complex. Recently, a single-balloon enteroscopy (SBE) system has been introduced as being a simplified, less-complex balloon-assisted enteroscopy system.
Sick-building syndrome.
Authors: J A Stolwijk
Journal: Environmental Health Perspectives (1991)

The sick-building syndrome (SBS) is defined as the occurrence of an excessive number of subjective complaints by the occupants of a building. These complaints include headache, irritation of the eyes, nose, and throat, lethargy, inability to concentrate, objectionable odors, and less frequently, nausea, dizziness, chest tightness, etc. These complaints will always be reported by a fraction of the occupants of any building if a questionnaire is administered that asks the respondent to recall any subjective symptoms they remember having had in the last 2 weeks or or over some period of time. It is often considered that SBS symptom reports have a minimum prevalence of about 15 to 20% for a 2-week recall period. SBS symptoms reported by 30% or more of occupants are indicative of conditions in the building environment that warrant attention. It is not often that a clear, single cause is responsible for the excess symptom reports. The following factors, often in combinations, are seen to contribute to SBS: outdoor air supply that is inadequate, ventilation distribution or effectiveness that is inadequate, the presence of temporary or long-term sources of contaminants such as tobacco smoke, adhesives, composite materials such as chipboard, and the growth of microorganisms in the HVAC equipment or in carpets or other furnishings. Depending on which causes contribute, the condition may be intermittent or even temporary. Psychosocial factors such as labor-management relations and satisfaction or dissatisfaction with other factors in the work environment can have a profound influence on the level of response of the occupants to their environment. Although hard data are difficult to collect, it is likely that productivity in the office environment is sensitive to conditions causing SBS.
DIET AND HEALTH
Authors: R. Chalmers
Journal: BMJ (1931)

OBITUARY[MEALJOURAL 605both cases alike, termination of the appointment estops any claim to superannuation.Similarly in the case of sick pensions: if an officer continues to serve after he has become entitled to a sick pension on medical grounds, and the authority subsequently sees fit to terminate his appointment, his claim to a sick pension is thereby forfeited.To many it may seem that such risks as these are infinitesimal; but, in fact, it is not so.Illustrative cases
Indium 111 autologous leucocyte scanning in lobar pneumonia and lung abscesses.
Authors: S H Saverymuttu, G Phillips, A M Peters, J P Lavender
Journal: Thorax (1985)

Indium 111 leucocyte scanning was used to examine the kinetics of granulocyte localisation in five patients with lobar pneumonia and four patients with lung abscess. Lung abscesses showed dense accumulation of labelled granulocytes within four hours of injection. In contrast, in all cases of lobar pneumonia granulocytes failed to accumulate over a period of up to 24 hours despite evidence of adequate perfusion and of uptake in inflammation elsewhere. These results suggest that the recruitment of granulocytes to lobar pneumonia may be terminated early in its clinical course.
The integration of motivation
Authors: Alan H. Bond, Michael Raleigh
Journal: Behavioral and Brain Sciences (1999)

We propose that a control system will address the causal dynamics of the neural network that Depue &amp; Collins regard as underlying extraversion. We briefly describe a control system approach and articulate the notion of integration. The integration of goals and regards is achieved by subcortical assessment of reward in the nucleus accumbens and VTA (ventral tegmental area) transmission of this information largely by dopaminergic systems and representation of reward in the MOC (medial orbital cortex). Thus reward information is collected, integrated, and evaluated in the MOC. Such control decisions rely on constraining processes, a functional property of the MOC mediated largely by serotonergic neurons.