tbuckley/cabot-search huggingface dataset:
Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.
Authors: D P McCauliffe, F A Lux, T S Lieu, I Sanz, J Hanke, M M Newkirk, L L Bachinski, Y Itoh, M J Siciliano, M Reichlin
Journal: Journal of Clinical Investigation (1990)

Ro/SS-A antibodies are found in a number of human autoimmune disorders including Sjogren's syndrome and several systemic lupus erythematosus-related disorders. These heterogeneous autoantibodies are known to recognize several distinct cellular antigens. With synthetic oligonucleotides corresponding to amino acid sequence information we have isolated a full-length cDNA clone which encodes a human Ro ribonucleoprotein autoantigen. The 1,890-base pair clone contains an open reading frame that encodes a 417-amino acid, 48-kD polypeptide that migrates aberrantly at 60 kD by SDS-PAGE. Rabbit antibodies raised against this protein's recently described amino-terminal epitope react with a previously identified 52-kD human Ro protein and immunoprecipitate the human cytoplasmic RNAs. Ultraviolet light cross-linking studies suggest that this Ro protein binds each of the four major human cytoplasmic RNAs. The deduced amino acid sequence is 63% homologous to an Onchocerca volvulus antigen. Southern filter hybridization analysis indicates that this gene is not highly polymorphic and exists as a single copy in the human genome. Chromosomal localization studies place this gene on the short arm of chromosome 19 near the gene encoding the low density lipoprotein receptor.
USE OF CORTICAL EXTRACT TO PROMOTE EXCRETION OF BROMIDES
Authors: Alfred Gilman
Journal: JAMA (1941)

To the Editor:—  The observations of Bondurant and Campbell appearing in the January 11 issue ofThe Journal, on the use of cortical extract to promote the excretion of bromide in cases of bromide intoxication, and the favorable comment which appears in the discussion of this paper are disconcerting in view of the chemical data presented. In the first place, the rationale which prompted the use of adrenal cortex extract in the treatment of bromism deserves closer scrutiny. It is true that, in adrenal cortical insufficiency, hypochloremia is a common finding and administration of cortical extract aids in returning the electrolyte composition of the blood toward normal. According to present concepts this is accomplished by promoting the renal reabsorption of sodium chloride, a defect in this mechanism existing in Addison's disease. The low blood chloride accompanying high levels of blood bromide, however, merely represents the replacement in the extracellular fluid
Improvement In Quality Of Life With Administration Of A 300 IR Sublingual Tablet Of 5-grass Pollen Allergen Extract In Adults With Grass Pollen-induced Allergic Rhinoconjunctivitis
Authors: F. Horak, A. Didier, M. Worm, H. Malling, K. Abiteboul, A. Montagut, R.K. Zeldin
Journal: Journal of Allergy and Clinical Immunology (2012)
The significance of a positive cutaneous immunofluorescence test in systemic lupus erythematosus
Authors: PAUL I. DANTZIG, JACQUELINE MAURO, SYRUS RAYHANZADEH, ULRICH H. RUDOFSKY
Journal: British Journal of Dermatology (1975)

Direct cutaneous immunofluorescence microscopical examination of uninvolved skin is an important diagnostic test in systemic lupus erythematosus. Its prognostic significance is undetermined. In twenty-four patients there was an increased incidence of leukopenia, hypocomplementaemia, and LE cells in patients with positive skin immunofluorescence. Positive cutaneous immunofluorescence of uninvolved skin was correlated with the most severe forms of lupus renal disease, membranous glomerulonephritis, and diffuse proliferative glomerulonephritis.
Changes in Proteins and Lipoproteins in Diabetes and their Relationship to Vascular Degeneration
Authors: J. C. DEMANET, P. E. GREGOIRE, P. A. BASTENIE
Journal: Circulation (1959)

The cause of atherosclerosis and reason for its high incidence in diabetes are not known. In this study proteins and lipoids of serums of patients with diabetes or atherosclerosis are examined by paper electrophoresis to determine whether such changes may be a common factor for both of these conditions.
Postprandial Hyperglycemia Is a Better Predictor of the Progression of Diabetic Retinopathy Than HbA1c in Japanese Type 2 Diabetic Patients
Authors: Toshihiko Shiraiwa, Hideaki Kaneto, Takeshi Miyatsuka, Ken Kato, Kaoru Yamamoto, Ayaha Kawashima, Tsutomu Kanda, Masaaki Suzuki, Eiichi Imano, Munehide Matsuhisa, Masatsugu Hori, Yoshimitsu Yamasaki
Journal: Diabetes Care (2005)

It is well known that postchallenge and postprandial hyperglycemia are related to the progression of diabetic macroangiopathy (1–6). However, there is little information regarding the association between diabetic microangiopathy and postprandial hyperglycemia in human subjects. In this study, we performed a follow-up study to elucidate the relationship between diabetic retinopathy and postprandial glycemia or insulinemia.

We recruited 151 Japanese patients with type 2 diabetes (74 men, aged 58.1 ± 10.2 years, and 77 women, aged 57.9 ± 9.2 years) who were admitted to Osaka Prefectural General Hospital between 1 January 1995 and 31 December 1999. The mean …
<i>Rooftops Under Snow</i>
Authors: Jeanette M. Smith
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Early Fatal Reaction to Blood Transfusion
Authors: A. A. Miller
Journal: BMJ (1953)

MEDICAL JOURNAL insulin (Organon) and alt-insulin (Horn)-the former act- ing somewhat more acutely than the latter.In the literature the normal duration of the action of regular insulin in diabetics is given as eight hours, so one may take this value to be well founded (Fig. 1).Categor y 2.-DEoration, 10 hours.To this category belong N.P.H. insulin (Organon), N.P.H. 50 (Lilly), depot insulin C 0-CASES (Horm), semilente (Novo), CONTROL 6 and zinc insulin ' neutrale " (Organon).These show only I 20U.minor differences in charac-N.PH.ter.The first three insulins INSULIN 0o60 5 'are protamine zinc insulins: -ORGANON" ~~N.P.H. insulin and N.P.H. NRe50 0X.10°0 005L4 5 50 being cloudy suspensions N.PH 50 0.060-5 'LILLY o;eo and depot insulin (Horm) a clear solution.The last two DEPOT 0.oooV-I i+ insulins are zinc insulins,
A METHOD OF PERFORMING EXTERNAL URETHROTOMY IN IMPASSABLE STRICTURE
Authors: A. B. CECIL
Journal: JAMA (1913)

The difficulties which have surrounded external urethrotomy have been only partially overcome by the later day operations. Young's method is by far the most practical procedure yet devised. In this operation the urethra is opened in the prostatic portion posterior to the stricture. At this point the urethra is easily located, as it is here dilated. Young's own description is quoted:  The vertex of the prostate was then exposed as in the operation for perinea] prostatectomy, after carefully dividing the central tendon and recto-urethralis muscle. By means of blunt dissection the membranous urethra and the anterior third of the prostate were exposed, the wound being held open by posterior and lateral retractors. A median incision was then made into the membranous urethra and the anterior portion of the prostatic urethra. It was found best to carry the incision back into the posterior urethra, because without a guide in the membranous
Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
Authors: Melanie M. Mahtani, Elisabeth Widén, Markku Lehto, Jeffrey Thomas, Mark McCarthy, James Brayer, Barbara Bryant, Gayun Chan, Mark Daly, Carol Forsblom, Timo Kanninen, Andrew Kirby, Leonid Kruglyak, Kevin Munnelly, Maikki Parkkonen, Mary Pat Reeve-Daly, Alix Weaver, Thomas Brettin, Geoffrey Duyk, Eric S. Lander, Leif C. Groop
Journal: Nature Genetics (1996)
Hodgkin's Disease: An Unusual Case with Spinal Symptoms
Authors: O. D. Beresford, N. G. B. McLetchie
Journal: BMJ (1948)

We record this case because it displays certain less-known features of lymphadenoma which are of greater moment than a mere record of unusual manifestations of a protean disease. Case HistoryThe patient, a house-decorator aged 49, was in good health until October, 1942, when he noticed a swelling of the neck.Clinical examination in December revealed a mass of firm discrete glands in the left side of the neck and supraclavicular region and some smaller glands in the right axilla.No other abnormality was found clinically and the patient felt well.The red cell count, haemoglobin estimation, and total and differ- ential white cell counts were normal.A large cervical gland was removed, and was reported on as a lymphadenoma by Dr. Fraser, pathologist to the Bristol Royal Infirmary.Radio- therapy was started in January, 1943, under the late Dr. Bryan Adams.(Details of radiotherapy are given in an Appendix.)In March, 1943, a nodule the size of a walnut still remained in the left side of the neck, but this had disappeared by May, 1943, when no other abnormality could be detected.The patient was examined at three-monthly intervals and was well until August, 1946, when he complained of pains in the back and down the right leg.Clinical examination.didnot reveal any abnormality.Radiological examination did not show tumour involvement of the vertebrae, but osteoarthritic changes were noticed.No treatment was given.One month later the patient was seen again ; he complained of having had lower abdominal pains, the character of which suggested girdle pains, and now had loss of power of the right leg and weakness of the left leg.On examination a mass in the right iliac fossa was found, with wasting of the right gluteus maxi- mus and of the right hamstrings, weakness of both lower limbs, especially the right, spasticity, exaggerated tendon reflexes, and analgesia corresponding to a cord lesion at the level of the tenth dorsal segment.Sphincter control was normal.No
Education, 15-Year Risk Factor Progression, and Coronary Artery Calcium in Young Adulthood and Early Middle Age
Authors: Lijing L. Yan, Kiang Liu, Martha L. Daviglus, Laura A. Colangelo, Catarina I. Kiefe, Stephen Sidney, Karen A. Matthews, Philip Greenland
Journal: JAMA (2006)

ContextThe inverse association between education and cardiovascular disease is well established, but little is known about the relationship between education and subclinical disease, which is free from medical access and treatment-related influences, or about possible mediating pathways for these relationships.ObjectiveTo examine the association of education with coronary artery calcium (CAC), an indicator of subclinical atherosclerosis, and cardiovascular risk factors, and their changes as potential mediators.Design, Setting, and ParticipantsA population-based, prospective, observational study (Coronary Artery Risk Development in Young Adults [CARDIA]) of 2913 eligible participants (44.9% black; 53.9% women) recruited from 4 metropolitan areas (Birmingham, Ala; Chicago, Ill; Minneapolis, Minn; and Oakland, Calif) in both the baseline (1985-1986, ages 18-30 years) and year 15 examinations (2000-2001, ages 33-45 years). Education (year 15) was classified into less than high school (n = 128), high school graduate (n = 498), some college (n = 902), college graduate (n = 764), and more than college (n = 621).Main Outcome MeasurePresence of CAC, measured twice by computed tomography (mean total Agatston score >0) at year 15.ResultsOverall CAC prevalence in this sample was 9.3%. After adjusting for age, race, and sex, the odds ratios (ORs) for having CAC were 4.14 (95% confidence interval [CI], 2.33-7.35) for less than high school education, 1.89 (95% CI, 1.23-2.91) for high school graduate, 1.47 (95% CI, 0.99-2.19) for some college, and 1.24 (95% CI, 0.84-1.85) for college graduate compared with those participants with more than a college education (P for trend<.001). This was also consistent within each of the 4 race-sex groups. Adjustment for baseline systolic blood pressure, smoking, waist circumference, physical activity, and total cholesterol reduced the ORs to 2.61 (95% CI, 1.40-4.85) for less than high school, 1.38 (95% CI, 0.88-2.17) for high school graduate, 1.17 (95% CI, 0.78-1.77) for some college, and 1.13 (95% CI, 0.76-1.69) for college graduate compared with more than a college education (P for trend = .01), and only slightly attenuated by further adjustment for 15-year changes in risk factors.ConclusionEducation was inversely associated with the prevalence of CAC, an association partially explained by baseline risk factors and minimally by 15-year changes in risk factors.
The Character of the Anti-Vivisectionist.
Authors: J. Winchell Forbes
Journal: JAMA (1896)

Cincinnati, Ohio, Feb. 15, 1896. <h3>To the Editor:</h3> —Among your comments on the vivisection bill of Mr. McMillan, on p. 297 of the issue of theJournalof February 8, you make use of the following language: "In the absence of knowledge of the subject, no one should chide these good hearted men and women, etc.," (no need to quote the remainder). Now my dear doctor, the "good book" (both versions) contains the following passage, "Fools rush in where angels fear to tread," in line with this statement is the fact of experience that ignorance will criticise, while knowledge is weighing evidence. It is also a known fact that an exaggerated idea of the specific individuals, qualifications and<i>ego</i>, is the prompter for the rendition of<i>judgment</i>by that individual, who thinks what he or she<i>thinks</i>, is necessarily<i>law</i>. It is a well-established principle of justice, and common sense
REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS
Authors: L. A. Julianelle, M. C. Morris
Journal: The Journal of Experimental Medicine (1932)

1. Following repeated intracutaneous injections of heat-killed S or R pneumococci, rabbits acquire an increased skin reactivity to the nucleoprotein of both Pneumococcus and indifferent Streptococcus. 2. Rabbits acquire a skin reactivity to the proteins of both the organisms mentioned after receiving intracutaneous injections of heat-killed indifferent streptococci. 3. Injections of pneumococci into the skin are followed in some rabbits by an eye sensitivity to pneumococcus protein but not to streptococcus protein nor to suspensions of either living organism. 4. Injections of indifferent streptococci into the skin are followed, in some rabbits, by an eye sensitivity to suspensions of live indifferent Streptococcus, but not to R Pneumococcus or to the nucleoprotein of either organism. Measured in terms of bacterial specificity therefore, the eye sensitivity possesses a specificity which is not shared by the skin sensitivity. 5. The sera of rabbits injected intracutaneously with pneumococci or indifferent streptococci contain agglutinins for both R Pneurnococcus and indifferent Streptococcus. 6. Only those animals injected with pneumococci acquire resistance to pneumococcal infection.
The Rewards of Clinical Trials: Disclosure
Authors: Steven Lipper
Journal: JAMA (1986)

To the Editor.—  We are in strong agreement with Dr Spiro 1 that full disclosure of financial and professional advantages accruing to the physician if a patient participates in a controlled clinical trial will enhance the patient's freedom to decide. It is not unusual for a patient to make or rationalize his decision to participate in research in the belief that the physician-researcher is acting solely in the patient's best interest.  Apart from any financial reward for enrolling patients in a clinical trial, the physician may already be subject to pressures and inducements that can compete with his ethical obligation to afford primacy to the interests of each patient. The investigator's uncompensated decision to enroll a particular patient in a research study may be based not only on a desire to help patients generically through discovering something medically beneficial, whether or not it can help an individual patient-participant, but also
The Fabric of the Body: European Traditions of Anatomical Illustration
Authors: John Cody
Journal: JAMA (1993)

The history of anatomical illustration has been curiously neglected. As long ago as 1920, Mortimer Frank, a Chicago physician, published his translation from the German of Ludwig Choulant's 1852 treatise on the subject. It is startling to realize that, until the present work, there has been nothing on a comparable scale since. Roberts and Tomlinson, therefore, are to be congratulated on breaking the wall of silence and producing a handsome, scholarly, and much needed work. Much has happened in the field since Choulant's day. Anatomic and medical art underwent a second flowering in the late 19th and 20th centuries, until now practically unrecorded, in works such as the atlases of Spalteholz, Sobotta, Pernkopf, and Grant, and in the individual talents of such artists as Frank Netter and Max Brödel. It is gratifying to see these contributions assigned their appropriate place in the long line of development dating from medieval times.
Survey of Simple Sequence Repeats in Completed Fungal Genomes
Authors: Haydar Karaoglu, Crystal Man Ying Lee, Wieland Meyer
Journal: Molecular Biology and Evolution (2004)

The use of simple sequence repeats or microsatellites as genetic markers has become very popular because of their abundance and length variation between different individuals. SSRs are tandem repeat units of 1 to 6 base pairs that are found abundantly in many prokaryotic and eukaryotic genomes. This is the first study examining and comparing SSRs in completely sequenced fungal genomes. We analyzed and compared the occurrences, relative abundance, relative density, most common, and longest SSRs in nine taxonomically different fungal species: Aspergillus nidulans, Cryptococcus neoformans, Encephalitozoon cuniculi, Fusarium graminearum, Magnaporthe grisea, Neurospora crassa, Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Ustilago maydis. Our analysis revealed that, in all of the genomes studied, the occurrence, abundance, and relative density of SSRs varied and was not influenced by the genome sizes. No correlation between relative abundance and the genome sizes was observed, but it was shown that N. crassa, the largest genome analyzed had the highest relative abundance of SSRs. In most genomes, mononucleotide, dinucleotide, and trinucleotide repeats were more abundant than the longer repeated SSRs. Generally, in each organism, the occurrence, relative abundance, and relative density of SSRs decreased as the repeat unit increased. Furthermore, each organism had its own common and longest SSRs. Our analysis showed that the relative abundance of SSRs in fungi is low compared with the human genome and that longer SSRs in fungi are rare. In addition to providing new information concerning the abundance of SSRs for each of these fungi, the results provide a general source of molecular markers that could be useful for a variety of applications such as population genetics and strain identification of fungal organisms.
Organic Brain Syndrome: Diagnostic Value of the EEG-Reply
Authors: William R. Dubin
Journal: JAMA (1983)

<h3>In Reply.—</h3> We are in complete agreement with the comments of Dr Alberto and colleagues about the value of using EEG recordings to differentiate organic brain disease from functional psychosis. The results of their study reaffirm the importance of the EEG in the diagnostic workup of the acutely confused patient. We did not discuss the EEG in our article because our study was carried out in an emergency department setting. Although our study focused on patients who were medically cleared, our psychiatric emergency service receives a large number of direct referrals who are acutely confused and have had no prior medical evaluation of their conditions. It would be logistically impossible to perform EEGs on such a large number of patients. Therefore, the purpose of our article was to help increase the physician's awareness of the potential for patients with organic brain disease to seem to be psychiatric patients. Without a
Regional transfusion centre preoperative autologous blood donation programme: the first two years.
Authors: M. R. Howard, C. E. Chapman, J. A. Dunstan, C. Mitchell, H. L. Lloyd
Journal: BMJ (1992)

OBJECTIVE--To assess the efficacy of a regional autologous blood donation programme. DESIGN--Clinical and laboratory data were collected and stored prospectively. Transfusion data were collected retrospectively from hospital blood bank records. SETTING--Northern Region Blood Transfusion Service and 14 hospitals within the Northern Regional Health Authority. SUBJECTS--505 patients referred for autologous blood donation before elective surgery. MAIN OUTCOME MEASURES--Patient eligibility, adverse events from donation, autologous blood units provided, and autologous and allogeneic blood units transfused within 10 days of operation. RESULTS--Of 505 patients referred, 354 donated at least one unit. 78 of 151 referred patients who did not donate were excluded at the autologous clinic, mostly because of anaemia or ischaemic heart disease. In 73 cases the patient, general practitioner, or hospital consultant decided against donation. 363 autologous procedures were undertaken. In 213 (59%) cases all requested units were provided. The most common reasons for incomplete provision were late referral or anaemia. Adverse events accompanied 24 of 928 donations (2.6%). Transfusion data were obtained for 357 of the 363 procedures. 281 donors were transfused; autologous blood only was given to 225, autologous and allogeneic blood was given to 52, and allogeneic blood only was given to four. 648 of 902 (72%) units of autologous blood were transfused. Complete provision of requested autologous units was followed by allogeneic transfusion in 12 of 208 procedures (5.8%). Incomplete provision was followed by allogeneic transfusion in 44 of 149 procedures (30%). CONCLUSIONS--This study shows the feasibility of a regional autologous transfusion programme. Autologous donors only infrequently received allogeneic transfusion. Patients should be appropriately selected and referred early.