Large Intracranial Arteritis with Giant Cells in Systemic Lupus Erythematosus
Authors: DOUGLAS SCHARRE
Journal: Annals of Internal Medicine (1986)

Brief Reports1 May 1986Large Intracranial Arteritis with Giant Cells in Systemic Lupus ErythematosusDOUGLAS SCHARRE, M.D., MICHELLE PETRI, M.D., ELAINE ENGMAN, M.D., STEPHEN DeARMOND, M.D., Ph.D.DOUGLAS SCHARRE, M.D.Search for more papers by this author, MICHELLE PETRI, M.D.Search for more papers by this author, ELAINE ENGMAN, M.D.Search for more papers by this author, STEPHEN DeARMOND, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-5-661 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeuropsychiatric manifestations in systemic lupus erythematosus have been reported extensively, but the central nervous system pathology has rarely been documented (1, 2). We studied the case of a patient who died with arteritis and occlusion of the left middle and posterior cerebral arteries. An arteritis with giant cells has not been described previously in systemic lupus erythematosus.A 29-year-old woman had had systemic lupus erythematosus for 3 years with Raynaud's phenomenon; mouth ulcers; polyarthritis; serositis; and diffuse proliferative glomerulonephritis. Tests for antinuclear antibody, anti-double-stranded DNA, and Sm antigen were positive. Recurrent flares were associated with headaches. Diffuse proliferative glomerulonephritis with...References1. JOHNSON R and RICHARDSON E. The neurological manifestations of systemic lupus erythematosus. Medicine (Baltimore). 1968;47:337-69. CrossrefMedlineGoogle Scholar2. ELLIS S and VERITY M. Central nervous system involvement in systemic lupus erythematosus: a review of neuropathologic findings in 57 cases, 1955-1977. Semin Arthritis Rheum. 1979;8:212-21. CrossrefMedlineGoogle Scholar3. SILVERSTEIN A. Cerebrovascular accidents as the initial major manifestation of lupus erythematosus. NY State J Med. 1963;63:2942-8. MedlineGoogle Scholar4. KELLEY R, STOKES N, REYES P, and HARIK S. Cerebral transmural angiitis and ruptured aneurysm: a complication of systemic lupus erythematosus. Arch Neurol. 1980;37:526-7. CrossrefMedlineGoogle Scholar5. MUSSINI J, PONGE T, BARRIER J, MUSSINI-MONTPELLIER J, and GROLLEAU J. Herpes zoster and cranial giant cell arteritis [Letter]. J Rheumatol. 1985;12:625. MedlineGoogle Scholar6. OJEDA V, PETERS D, and SPAGNOLO D. Giant cell granulomatous angiitis of the central nervous system in a patient with leukemia and cutaneous herpes zoster. Am J Clin Pathol. 1984;81:529-32. CrossrefMedlineGoogle Scholar7. ELIAS M and ELDOR A. Thromboembolism in patients with the 'lupus'-type circulating anticoagulant. Arch Intern Med. 1984;144:510-5. CrossrefMedlineGoogle Scholar8. CUPPS T and FAUCI A. The Vasculitides. Philadelphia: W. B. Saunders Company; 1981:126. Google Scholar9. ROTHENBERG R. Isolated angiitis of the brain: case in a renal transplant recipient. Am J Med. 1985;79:629-32. CrossrefMedlineGoogle Scholar10. DELANEY P and ESTES M. Intracranial hemorrhage with amphetamine abuse. Neurology. 1980;30:1125-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DOUGLAS SCHARRE, M.D.; MICHELLE PETRI, M.D.; ELAINE ENGMAN, M.D.; STEPHEN DeARMOND, M.D., Ph.D.Affiliations: University of California San Francisco Letterman Army Medical Center San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVasculitis in lupusIsolated Cerebral Vasculitis in the Unilateral Middle Cerebral Artery in a Case with SLEVasculitis in LupusCerebral large vessel vasculitis in systemic lupus erythematosusTransient ischemic attack and stroke in systemic lupus erythematosusDifferential Diagnosis and Disease AssociationsThe Enigma of VasculitisVasculitisVascular DementiaRADIOGRAPHIC FEATURES OF CENTRAL NERVOUS SYSTEM VASCULITISGRANULOMATOUS ANGIITIS OF THE NERVOUS SYSTEMKopfschmerz bei GefäßstörungenCase 30-1996Wegener's granulomatosis presenting as temporal arteritisGiant Cell Vasculitis with Extravascular Granulomas in an AdolescentThe Vasculitis Syndromes in Small- and Medium-Sized VesselsGiant cell arteritis and systemic lupus erythematosusCerebral thrombophlebitis in a patient with systemic lupus erythematosus. 1 May 1986Volume 104, Issue 5Page: 661-662KeywordsArthritisCentral nervous systemCerebral arteriesDNAGiant cellsGlomerulonephritisLupus erythematosusMouthRaynaud syndromeUlcers ePublished: 1 December 2008 Issue Published: 1 May 1986 Copyright & Permissions© 1986 American College of PhysiciansPDF downloadLoading ...