tbuckley/cabot-search huggingface dataset:
Improved Survival Among Patients With Eisenmenger Syndrome Receiving Advanced Therapy for Pulmonary Arterial Hypertension
Authors: Konstantinos Dimopoulos, Ryo Inuzuka, Sara Goletto, Georgios Giannakoulas, Lorna Swan, Stephen J. Wort, Michael A. Gatzoulis
Journal: Circulation (2009)

Background— Advanced therapy (AT) for pulmonary arterial hypertension in the context of congenital heart disease (Eisenmenger syndrome) improves pulmonary hemodynamics, functional class, and the 6-minute walk test. We examined the potential effect of AT on survival in this population. Methods and Results— Data on all Eisenmenger patients attending our center over the past decade were collected. Survival rates were compared between patients on and off AT with the use of a modified version of the Cox model, which treats AT as a time-varying covariate. Baseline differences were adjusted for the use of propensity scores. A total of 229 patients (aged 34.5±12.6 years; 35.4% male) were included. The majority had complex anatomy, and 53.7% were in New York Heart Association class ≥III at baseline assessment. Mean resting saturations were 84.3%. Sixty-eight patients (29.7%) either were on AT or had AT initiated during follow-up. During a median follow-up of 4.0 years, 52 patients died, only 2 of them while on AT. Patients on AT were at a significantly lower risk of death, both unadjusted and after adjustment for baseline clinical differences by propensity score regression adjustment ( C statistic=0.80; hazard ratio, 0.16; 95% confidence interval, 0.04 to 0.71; P =0.015) and propensity score matching (hazard ratio, 0.10; 95% confidence interval, 0.01 to 0.78; P =0.028). Conclusions— AT for pulmonary arterial hypertension in a contemporary cohort of adults with Eisenmenger syndrome was associated with a lower risk of death. Survival benefits should be considered together with improved hemodynamics and functional class when decisions are made about AT in this population.
Reversion of hepatic stellate cell to a quiescent phenotype: From myth to reality?
Authors: Ariane Mallat, Sophie Lotersztajn
Journal: Journal of Hepatology (2013)

Myofibroblasts produce the fibrous scar in hepatic fibrosis.In the carbon tetrachloride (CCl(4)) model of liver fibrosis, quiescent hepatic stellate cells (HSC) are activated to become myofibroblasts.When the underlying etiological agent is removed, clinical and experimental fibrosis undergoes a remarkable regression with complete disappearance of these myofibroblasts.Although some myofibroblasts apoptose, it is unknown whether other myofibroblasts may revert to an inactive phenotype during regression of fibrosis.We elucidated the fate of HSCs/myofibroblasts during recovery from CCl(4)and alcohol-induced liver fibrosis using Cre-LoxP-based genetic labeling of myofibroblasts.Here we demonstrate that half of the myofibroblasts escape apoptosis during regression of liver fibrosis, down-regulate fibrogenic genes, and acquire a phenotype similar to, but distinct from, quiescent HSCs in their ability to more rapidly reactivate into myofibroblasts in response to fibrogenic stimuli and strongly contribute to liver fibrosis.Inactivation of HSCs was associated with up-regulation of the anti-apoptotic genes Hspa1a/b, which participate in the survival of HSCs in culture and in vivo. AND
[256] EFFECTIVENESS OF SURVEILLANCE FOR HEPATOCELLULAR CARCINOMA IN CIRRHOTIC PATIENTS: A PROSPECTIVE STUDY IN A SINGLE TERTIARY-CARE CENTRE
Authors: G.G. Pi Costanzo, P. Pagliano, T. Ascione, P.P. Picciotto, G. Tritto, F. Lampasi, M. De Luca, A. Galeota Lanza, T. Tartaglione, L. Addario, A. Ascione
Journal: Journal of Hepatology (2007)
DOUBLE UTERUS WITH PREGNANCY
Authors: GOODRICH C. SCHAUFFLER
Journal: JAMA (1941)

In the last six years I have seen 11 patients<sup>1</sup>with more or less complete duplex anomalies of the uterovaginal tract, each of whom has had one or more pregnancies (a total of thirty-two). The present discussion applies strictly to the association of the two conditions; no attempt is made to present embryologic or purely gynecologic considerations, and my approach is from the clinical rather than from the academic side. Briefly, duplex anomalies of the uterovaginal tract are due to (1) irregularities of fusion involving the normal junction of the müllerian ducts to form the symmetrical halves of the corpus of the uterus and (2) irregularities in canalization involving the urogenital sinus or lower uterine and vaginal tracts. The most common anomaly is simple uterus arcuatus, departing little from the normal contours and hence not as often important clinically. I have not included such cases. The misfortunes that occur
A Comparison Between Four Simple Methods for Measuring Glomerular Filtration Rate Using Technetium-99m DTPA
Authors: M GINJAUME, M CASEY, F BARKER, G DUFFY
Journal: Clinical Nuclear Medicine (1986)

Numerous centers perform glomerular filtration rate (GFR) measurements on patients undergoing renal imaging with Tc-99m DTPA. GFR measurement, however, does involve multiple blood samples taken over a 4-hour period, and this has led to attempts to simplify the technique by reducing the number of blood samples required and hence diminish the time taken to perform the test and the inconvenience to the patient. Four different simplified techniques for measuring GFR that have been reported in the literature are compared with a reference 2 blood sample method. Three of the methods do not require any blood samples but have standard errors of >20 ml /min in adults and >14 ml /min in children. The other method requires one blood sample, and if this is taken at 2 hours postinjection, the standard error is 9 ml /min in adults and 5 ml/min in children. The latter method is suitable for routine use in renography when accuracy is not of paramount importance.
THE MATURATION OF WESTERN EQUINE ENCEPHALOMYELITIS VIRUS AND ITS RELEASE FROM CHICK EMBRYO CELLS IN SUSPENSION
Authors: Harry Rubin, Marcel Baluda, John E. Hotchin
Journal: The Journal of Experimental Medicine (1955)

Experiments are presented in which the plaque assay technique was used to study the intracellular appearance and release of Western equine encephalomyelitis virus in suspensions of infected chick embryo fibroblasts. No intracellular virus could be found during the 1st hour after adsorption in spite of the fact that more than 10(14) cells per ml. proved to be infected. This is taken to indicate that the infecting particle loses its infectivity upon entering a susceptible cell. The first progeny virus was detectable in the cells between 1 and 2 hours after infection, and it increased in amount exponentially during the following 3 hours. The released virus as measured in the supernatant fluid increased at the same rate as the intracellular virus but exceeded it in amount by a factor of about twenty at all times during the period of exponential increase. More than 100 particles were spontaneously released from each cell, by the end of the period of exponential increase, yet the maximum number of intracellular infective particles at any instant during this period was never more than an average of from 4 to 10 per cell. Calculations based on these findings indicate that, on the average, a virus particle is released from the cell within 1 minute after it gains the property of infectiousness.
Cutaneous ulcers: An unusual manifestation of inherited thrombophilia
Authors: Clio P. Mavragani, Dimitris Pikazis, Kyriaki Aroni, Spiros Paikos, Michalis Voulgarelis
Journal: American Journal of Hematology (2004)

Abstract We report two cases with cutaneous lesions found to be associated with factor V Leiden mutation and low S protein levels. At the time of presentation, no other symptoms were reported. Histopathology of both lesions revealed the presence of widespread intravascular thrombi. The therapeutic response to oral anticoagulants in the first case was dramatic, leading to complete healing of the lesions. Inherited causes of thrombophilia manifested as cutaneous lesions, although rare, should be considered in the differential diagnosis of occlusive vasculopathy. Am J Hematol 76:139–142, 2004. © 2004 Wiley‐Liss, Inc.
Computed Tomography and Psychiatric Disorders
Authors: FRED OVSIEW
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 January 1982Computed Tomography and Psychiatric DisordersFRED OVSIEW, M.D.FRED OVSIEW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-1-126_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent papers by Larson and colleagues (1) on the cost effectiveness of computed tomography (CT) scanning in psychiatric patients is in the good company of many similar studies of the use of high-technology diagnostic procedures. Arguing with the economics or quarreling with the authors' methods is difficult.But the authors assume that "case finding" or reassurance for the physician is the only possible gain from a CT scan. By case finding they mean identifying a nonpsychiatric brain disease, and thus nonspecific findings such as atrophy are considered irrelevant. This ignores completely the growing body of data...References1. LARSONMACKWATTSCROMWELL ELBL. Computed tomography in patients with psychiatric illnesses: advantage of a "rule-in" approach. Ann Intern Med. 1981;95:360-4. LinkGoogle Scholar2. DONNELLYWEINBERGERWALDMANWYATT EDIR. Cognitive impairment associated with morphological brain abnormalities on computed tomography in chronic schizophrenic patients. J Nerv Ment Dis. 1980;168:305-8. CrossrefMedlineGoogle Scholar3. LUCHINSWEINBERGERWYATT DDR. Schizophrenia: evidence for a subgroup with reversed cerebral asymmetry. Arch Gen Psychiatry. 1979;36:1309-11. CrossrefMedlineGoogle Scholar4. WEINBERGERCANNON-SPOORPOTKINWYATT DESR. Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. Am J Psychiatry. 1980;137:1410-3. CrossrefMedlineGoogle Scholar5. WEINBERGERBIGELOWKLEINMANKLEINROSENBLATTWYATT DLJSJR. Cerebral ventricular enlargement in chronic schizophrenia: an association with poor response to treatment. Arch Gen Psychiatry. 1980;37:11-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1982Volume 96, Issue 1Page: 126-127KeywordsAtrophyBrain diseasesComputed axial tomography ePublished: 1 December 2008 Issue Published: 1 January 1982 PDF downloadLoading ...
Biosynthetic Human Insulin: Effect in Healthy Men on Plasma Glucose and Non-Esterified Fatty Acids in Comparison with Highly Purified Pork Insulin
Authors: G C Viberti, J C Pickup, H Keen, R W Bilous, M Mattock, R J Jarrett, A Glynne, R Rogers
Journal: Diabetes Care (1981)

Biosynthetic human insulin (BHI) produced by recombinant DNA technology was administered subcutaneously and intravenously at two dose levels to two groups, each consisting of six normal men. Responses were compared with those for purified pork insulin (PPI) given by the same routes at the same dose levels to the same two groups. The glycemic response to the insulins was similar with a suggestion (seen both with intravenous and subcutaneous administration) that the glycemic depression with BHI was slightly greater at low dose and less at high dose. No significant difference between insulin types was found in the depression of non-esterified fatty acid (NEFA) concentrations, although significant differences between types with low-dose subcutaneous injection emerged during the later phases of the experiment. After termination of high-rate infusion with both insulins, NEFA concentrations rose more rapidly with some overshoot, suggesting that the rate and depth of blood glucose fall in these experiments might have triggered a brisker counterregulatory response. The small differences found between human and pork insulins, although in some cases significant, are unlikely to be of clinical importance.
Cryptosporidial diarrhoea in AIDS and its treatment.
Authors: G M Connolly, M S Dryden, D C Shanson, B G Gazzard
Journal: Gut (1988)

Of 234 patients with AIDS diagnosed at St. Stephen9s Hospital between January 1981 and June 1987, 26 (11%) were found to have cryptosporidiosis. Stool examination was positive in all patients, but an average of three specimens (range 1-6) were required before a positive diagnosis was made. Other methods of diagnosis included jejunal and rectal biopsy and aspiration of the duodenal contents. Twenty three (89%) lived for six months from the time of diagnosis and 16 (60%) were alive at one year. Only five patients died as a direct result of cryptosporidial infection, while 10 other patients died from another complication of AIDS. Fifteen patients were enrolled in a prospective controlled study of erythromycin or spiramycin in the treatment of cryptosporidial diarrhoea. Most patients showed a significant response to antibiotic therapy but treatment was limited because of side effects. All patients responded to antidiarrhoeal agents, particularly long acting morphine sulphate. Three of our patients recently given zidovudine (AZT) have responded with a cessation of diarrhoea and cryptosporidia are no longer isolated from the stools.
Free-Breathing 3 T Magnetic Resonance T2-Mapping of the Heart
Authors: Ruud B. van Heeswijk, Hélène Feliciano, Cédric Bongard, Gabriele Bonanno, Simone Coppo, Nathalie Lauriers, Didier Locca, Juerg Schwitter, Matthias Stuber
Journal: JACC. Cardiovascular imaging (2012)
Intravenous Fluosol in the treatment of acute myocardial infarction. Results of the Thrombolysis and Angioplasty in Myocardial Infarction 9 Trial. TAMI 9 Research Group.
Authors: T C Wall, R M Califf, J Blankenship, J D Talley, M Tannenbaum, M Schwaiger, G Gacioch, M D Cohen, M Sanz, J D Leimberger
Journal: Circulation (1994)

BACKGROUND This study was performed to determine the safety and potential efficacy of an intravenous perfluorochemical emulsion (Fluosol) as an adjunct reperfusion therapy aimed at preventing reperfusion injury for patients with acute myocardial infarction. METHODS AND RESULTS Patients (430) were randomized in a prospective open-labeled study, 213 to receive Fluosol and 217 to receive no Fluosol, along with 100 mg of tissue-type plasminogen activator given over 3 hours. Major end points included global ejection fraction, regional wall motion analysis, infarct size as measured by tomographic thallium imaging, and a composite clinical outcome measure. Baseline patient and angiographic characteristics were similar in the two groups. No significant difference in global ejection fraction (52% without Fluosol, 51% with Fluosol) or regional wall motion (-2.4 SD/chord with Fluosol, -2.2 SD/chord without Fluosol) was demonstrated in patients receiving Fluosol versus those not receiving Fluosol, nor was there a significant difference in thallium infarct size. Although Fluosol-treated patients with anterior infarction had an insignificantly lower mean infarct size (18.7% of the left ventricle) compared with patients with anterior infarction not treated with Fluosol (21.2% of left ventricle), this trend was not evident in the median infarct size values (22% versus 17%), left ventricular ejection fraction values (46% without Fluosol, 47% with Fluosol), or regional wall motion (-2.5 SD/chord in both groups). Rates of death and stroke were no different in the two groups; however, patients who received Fluosol experienced less recurrent ischemia. Patients receiving intravenous Fluosol had more transient congestive heart failure and pulmonary edema, perhaps because of necessary fluid administration. There was no difference in hemorrhagic complications between the two study groups. CONCLUSIONS When given with a thrombolytic agent, Fluosol was not associated with improvement in ventricular systolic function, reduction in thallium infarct size, or overall clinical outcome. Fluosol was, however, associated with a reduction in ischemic complications and with an increase in pulmonary edema and congestive heart failure.
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
Authors: Chuka A. Didigu, Craig B. Wilen, Jianbin Wang, Jennifer Duong, Anthony J. Secreto, Gwenn A. Danet-Desnoyers, James L. Riley, Phillip D. Gregory, Carl H. June, Michael C. Holmes, Robert W. Doms
Journal: Blood (2013)
A Report of Fluorosis in the United States Secondary to Drinking Well Water
Authors: Arnold J. Felsenfeld, Mark A. Roberts
Journal: JAMA (1991)

A 54-year-old female resident of Wellston, Okla, was found to have osteosclerosis on a routine chest roentgenogram. Subsequent investigation disclosed the cause of her osteosclerosis to be fluorosis secondary to the ingestion of well water containing 429 μmol/L of fluoride (recommended levels, 11 to 58 μmol/L). Water samples were also obtained from the 12 wells on properties adjacent to the index case. In three other wells, all at similar depths as the well of the index case, the fluoride concentration of the water was greater than 212 μmol/L. Urine samples from members of the four households who obtain their drinking water from these wells contained elevated urinary fluoride levels. Thus, fluorosis may develop in certain areas of the United States as a result of the natural occurrence of fluoride in the groundwater. Consequently, in known endemic areas, it would appear reasonable to measure the fluoride concentration of the well water at the time of drilling. (<i>JAMA</i>. 1991;265:486-488)
Mucin-bacterial interactions in the human oral cavity and digestive tract
Authors: Muriel Derrien, Mark W.J. van Passel, Jeroen H.B. van de Bovenkamp, Raymond Schipper, Willem de Vos, Jan Dekker
Journal: Gut Microbes (2010)

Mucins are a family of heavily glycosylated proteins that are the major organic components of the mucus layer, the protective layer covering the epithelial cells in many human and animal organs, including the entire gastro-intestinal tract. Microbes that can associate with mucins benefit from this interaction since they can get available nutrients, experience physico-chemical protection and adhere, resulting in increased residence time. Mucin-degrading microorganisms, which often are found in consortia, have not been extensively characterized as mucins are high molecular weight glycoproteins that are hard to study because of their size, complexity and heterogeneity. The purpose of this review is to discuss how advances in mucus and mucin research, and insight in the microbial ecology promoted our understanding of mucin degradation. Recent insight is presented in mucin structure and organization, the microorganisms known to use mucin as growth substrate, with a specific attention on Akkermansia muciniphila, and the molecular basis of microbial mucin degradation owing to availability of genome sequences.
Experiences with 1,000 Fiberscopic Examinations of the Stomach.
Authors: Norman N. Cohen
Journal: Annals of Internal Medicine (1965)

s1 May 1965Experiences with 1,000 Fiberscopic Examinations of the Stomach.Norman N. Cohen, M.D. (Associate), Rollin W. Hughes Jr., M.D., Hector E. Manfredo, M.D.Norman N. Cohen, M.D. (Associate)Search for more papers by this author, Rollin W. Hughes Jr., M.D.Search for more papers by this author, Hector E. Manfredo, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1080_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development of the gastroduodenal fiberscope has been a major advance in gastrointestinal endoscopy. This report will include an analysis of 1,000 examinations, chosen solely on the basis of chart availability from 1,200 examinations performed under the supervision of the senior author. The advantages and disadvantages of the fiberscope compared with the conventional gastroscope will be discussed. These include blind areas, complications, discomfort to the patient, optical definition, and ease of passage. In none of the studies has the examiner been certain the instrument entered the duodenum. The prepyloric area, fundus, efferent and afferent loops of the gastroenterostomy are usually... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Norman N. Cohen, M.D. (Associate); Rollin W. HughesJr., M.D.; Hector E. Manfredo, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1080-1080KeywordsChartsDuodenumEndoscopyGastroenterology and hepatologyStomach ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...
Religion and the Skin: Devotional Dermatoses
Authors: Barry Ladizinski, Kachiu C. Lee
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Paracrine hypertrophic factors from cardiac non-myocyte cells downregulate the transient outward current density and Kv4.2 K+ channel expression in cultured rat cardiomyocytes
Authors: W Guo
Journal: Cardiovascular Research (1999)

Objectives: Cardiac hypertrophy is characterized by a prolongation of action potential duration (APD) and a reduction of outward K+ currents, primarily the transient outward current (Ito). Since the interaction between cardiac non-myocyte cells (NMCs) and cardiomyocytes (MCs) plays a critical role during the process of myocardial hypertrophy, in the present study, we investigated the effects of NMCs on cell growth and K+ channel expression in cultured newborn rat ventricular cells. Methods: Single MCs were isolated from day-old Wistar rat ventricles and cultured for a period of five days. The effects of NMCs were examined by MC–NMC co-culture or incubating pure MCs in NMC-conditioned growth medium (NCGM). Whole-cell voltage–clamp recording and Western blot analysis using a polyclonal antibody against rat Kv4.2 channel protein were performed. Results: A marked increase in surface area and total cell protein concentration of MCs was observed in the MC–NMC co-culture. In the pure MC culture, this hypertrophic effect could be mimicked by a 72-h addition of NCGM, with a significant prolongation of APD25 (APD at 25% repolarization) and a 42% decrease in Ito density (at +30 mV). The rates of inactivation and recovery from inactivation of Ito were unchanged. In the NCGM-treated MC culture, Western blots of MC proteins also showed a 36% reduction of the Kv4.2 K+ channel protein level. In addition, the NCGM-induced MC hypertrophy was partially inhibited by anti-insulin-like growth factor-1 (IGF-1) antibody, while it revealed no effects on Ito density and Kv4.2 channel expression. Conclusions: These findings first demonstrate that some paracrine hypertrophic factors released from cardiac NMCs, although unidentified, downregulate cardiac K+ channel expression.