tbuckley/cabot-search huggingface dataset:
Patients' passports pop up again
Authors: Nicholas Timmins
Journal: BMJ (2005)

Similarities between the Tory and Labour plans for the NHS mask the Tories' big idea—a subsidyfor patients who choose to go private. Nicholas Timmins reports

The conventional wisdom in much of the media is that there is not much difference between Labour and the Conservatives when it comes to the NHS. Both are fighting over whether the extra NHS spending since 1997, a doubling in cash terms by this year and a near doubling in real terms by 2007-8, after discounting for inflation, has been wasted. They battle jointly over access, choice, waiting lists, and bureaucracy in remarkably similar language and, in some areas, remarkably similar policies.

But that is to miss two absolute firsts. For the first time since the foundation of the NHS in1948, the Conservatives are going into a general election with spending promises that, at least at the time of writing, stretch further into the future than Labour's. The second, against this apparent total commitment to the NHS, is an opposite—a promise to break with more than 50 years of history and to offer patients and the private sector a direct subsidy if patients choose to leavethe NHS and go private.

The first is a measure of how far Labour has won the battle over the need to increase NHS expenditure. There may be doubts over whether the extra spending has produced enough improvement. Butthe Conservative plans to match Labour's spending …
Rifampicin and folate and vitamin B12 assays.
Authors: A J Cole, J Bate, O H Gyde
Journal: BMJ (1973)

The principal role of the consultant psychiatrist must be to bestow therapeutic skill on other workers (including general practitioners, social workers, health visitors, and ward nurses).This is not only dictated by arithmetic-it also offers the only hope for prevention.Mr. Bury is right to insist that psychiatry become more effective, but he should be warned not to expect it (or psychiatrists) to become popular; for it deals with the nost unpopular of human feelings.-I am, etc.,
Association of the ANRS-12126 Male Circumcision Project with HIV Levels among Men in a South African Township: Evaluation of Effectiveness using Cross-sectional Surveys
Authors: Bertran Auvert, Dirk Taljaard, Dino Rech, Pascale Lissouba, Beverley Singh, Julie Bouscaillou, Gilles Peytavin, Séverin Guy Mahiane, Rémi Sitta, Adrian Puren, David Lewis
Journal: PLoS Medicine (2013)

Betran Auvert and colleagues report findings from the Bophelo Pele project, a community-based HIV prevention intervention offering free voluntary medical male circumcision (VMMC), that demonstrate an association between VMMC roll-out and a reduction in the incidence and prevalence of HIV in the community. Please see later in the article for the Editors' Summary
Antineutrophil cytoplasmic antibodies in sera from colectomised ulcerative colitis patients and its relation to the presence of pouchitis.
Authors: M Esteve, J Mallolas, J Klaassen, A Abad-Lacruz, F Gonzalez-Huix, E Cabre, F Fernandez-Banares, X Bertran, E Condom, J Marti-Rague, M A Gassull
Journal: Gut (1996)

Few studies have evaluated the influence of colectomy on antineutrophil cytoplasmic antibody (ANCA) positivity in ulcerative colitis (UC). In small series of patients it has been suggested that ANCA positivity in UC might be predictive for development of pouchitis after colectomy.To assess the prevalence of ANCA in UC patients treated by colectomy and a Brooke's ileostomy (UC-BI) or ileal pouch anal anastomosis (UC-IPAA), and the relation between the presence of ANCA, the type of surgery, and the presence of pouchitis.63 UC patients treated by colectomy (32 with UC-BI and 31 with UC-IPAA), 54 UC, and 24 controls.Samples were obtained at least two years after colectomy. ANCA were detected by indirect immunofluorescent assay.There were no differences between patients with (36.3%) or without pouchitis (35.0%) and between patients with UC (55%), UC-BI (40.6%), and UC-IPAA (35.4%). However, ANCA prevalence significantly decreases in the whole group of operated patients (38.0%) compared with non-operated UC (p = 0.044).The prevalence of ANCA in operated patients was significantly lower than in non-operated UC, suggesting that it might be related either to the presence of inflamed or diseased tissue. ANCA persistence is not related to the surgical procedure and it should not be used as a marker for predicting the development of pouchitis.
Cushing's syndrome induced by hypersecretion of cortisol from only one of bilateral adrenocortical tumors
Authors: Sumio Kato, Rumi Masunaga, Tetsuya Kawabe, Akio Nagasaka, Takako Miyamoto, Motoko Itoh, Akira Nakai, Katsumi Iwase, Toru Tsujimura, Susumu Ohtani, Asako Inagaki, Kaoru Miura, Hitoshi Chikamatsu, Hitoshi Hishida, Yasushi Mizuno
Journal: Metabolism (1992)
Mechanisms and applications of hypertonic saline
Authors: Mark R Elkins, Peter Tp Bye
Journal: Journal of the Royal Society of Medicine (2011)

Hypertonic saline is a strong sterile solution of salt water that can be inhaled as a nebulized medication for people with cystic fibrosis (CF). To examine how it should be applied clinically, it is worth considering the mechanisms by which it affects the disease process, and which signs, symptoms and other clinical outcomes it influences. Finally, it is worth considering how the effect is influenced by the dose received, and whether this should influence how it is applied in clinical practice. This paper will review this information and relate it to the clinical application of hypertonic saline.
Surfactant extract reduces infant respiratory distress
Authors: Charles Marwick
Journal: JAMA (1983)

A purified extract of surfactant obtained from human amniotic fluid has successfully reduced the problems of managing respiratory distress syndrome (RDS) in a group of nine premature infants. A single endotracheal dose of 60 mg/kg of the surfactant resulted in a dramatic rise in oxygen tension as well as other favorable effects, permitting the investigators to cut in half the amount of oxygen the infants were given compared with 17 control patients who received conventional intermittent ventilation. Such measures can reduce the chances of oxygen toxicity. The results, reported by T. Allen Merritt, MD, assistant professor of pediatrics of the University of California, San Diego, School of Medicine at the meeting of the American Pediatric Society-Society for Pediatric Research in Washington, DC, were described as a major advance by Sumner Yaffe, MD, director of the Center for Research for Mothers and Children of the National Institute for Child Health and
Tomotherapy after Pleurectomy/Decortication or Biopsy for Malignant Pleural Mesothelioma Allows the Delivery of High Dose of Radiation in Patients with Intact Lung
Authors: Emilio Minatel, Marco Trovo, Jerry Polesel, Imad Abu Rumeileh, Tania Baresic, Alessandra Bearz, Alessandro Del Conte, Giovanni Franchin, Carlo Gobitti, Annalisa Drigo, Andrea Dassie, Vittore Pagan, Mauro G. Trovo
Journal: Journal of Thoracic Oncology (2012)
GMC says it will watch curriculum reforms
Authors: L Dillner
Journal: BMJ (1994)

Medical schools in the United Kingdom will have to change their curriculums dramatically and report annually to the General Medical Council (GMC) on the progress of their reforms. The GMC's latest recommendations on curriculum reform emphasise that the council will ensure that changes are implemented. Professor David Shaw, chairman of the GMC's education committee, said that the GMC had been urging medical schools to reduce the factual content of their courses since 1863.

* Students will be encouraged to teach themselves

(Fig Omitted)

“Most medical schools already seem to have major revisions of their curriculum going on at the moment. Change is happening quite rapidly. But we are committed to these reforms, and …
Abstract 13218: Adverse Effects and Incidence of Post-Rewarming Pyrexia in Patients Treated With Therapeutic Hypothermia After Cardiac Arrest
Authors: Marion Leary, Anne V Grossestreuer, Emily C Esposito, Gary D Wendell, David F Gaieski, Benjamin S Abella
Journal: Circulation (2011)

Background: Therapeutic hypothermia (TH) has been shown to improve clinical outcomes in patients resuscitated from cardiac arrest. The adverse effect profile of TH, including rebound pyrexia early ...
SOME NEW OBSERVATIONS ON THE DIAGNOSIS AND TREATMENT OF SYPHILIS
Authors: Thos. Anwyl-Davies
Journal: BMJ (1933)

SYPHILIS rTEBICRIJOTUSRAL 487and in one case neurological symptoms became apparent for the first time during treatment.Similar results are reported by Ungley.(c) Haema.tological.-Atendency for the colour index to rise under marmite therapy, due to the increase of haemoglobin in relation to red cells, is seen in cases reported by Goodall, Ungley, and myself.No satis- factory explanation for this is "available.As previously noted, yeast products are valueless in the treatrment of iron-deficiency anaemias in human beings. CONCLUSIONSThe therapeutic effects of yeast products in different types of anaemiia are reviewed.Records of sixteen cases of Addisonian pernicious anaemia treated with autolysed yeast products or alcoholic extracts made therefrom are described and compared with the results of other workers in this field.The conclusion is reached that such pro- ducts contain some haeimiopoietic principle, the value of which is discussed, but its concentration is snmall, as judged by many therapeutic failures, relative or absolute.For this reason, autolysed yeast products in their present form should not be used as substitutes for liver, liver extract, or hog's stomach tissue in the treatment of pernicious anaemia.
Soluble L-selectin level is a marker for coronary artery disease in type 2 diabetic patients.
Authors: J P Albertini, P Valensi, B Lormeau, J Vaysse, J R Attali, L Gattegno
Journal: Diabetes Care (1999)

To investigate whether the fall in soluble L-selectin (sL-selectin) level constitutes a marker for myocardial ischemia.The levels of soluble forms of adhesion molecules, i.e., intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE-selectin), P-selectin (sP-selectin), and L-selectin (sL-selectin), were compared in type 2 diabetic patients without inflammatory syndrome but with symptomatic coronary artery disease (CAD) (group 1, n = 11), with silent ischemic disorders and proven coronary stenoses (group 2, n = 11), with silent myocardial ischemia (SMI) and normal coronary angiography (group 3, n = 10), and without proven SMI (group 4, n = 13). These levels were compared with those of 22 control subjects.The sL-selectin level was significantly lower in groups 1, 2, or 3 with symptomatic CAD or with SMI as compared with the control group (P = 0.0004). Group 4 without myocardial ischemia did not significantly differ from the control subjects (P = 0.6). In type 2 diabetic patients, after controlling for HbA1c, a partial correlation between sL-selectin and the CAD status was significant (P = 0.001). sICAM-1 and sP- or sE-selectin did not differ significantly between type 2 diabetic patients and control subjects or among the different groups of patients. The sVCAM-1 level in type 2 diabetic patients was significantly higher than in the control subjects (P = 0.001), but there were no significant intergroup differences (P = 0.4).In type 2 diabetic patients, sVCAM-1 is increased with regard to glycemic control, whatever the CAD status. In type 2 diabetic patients with symptomatic CAD or SMI associated with coronary stenoses, sL-selectin is significantly decreased. A marked fall in sL-selectin might constitute a marker for silent CAD in type 2 diabetic patients.
Bromocriptine for an Acromegalic Patient
Authors: Rafael Luboshitzky
Journal: JAMA (1980)

A 64-year-old woman with active acromegaly of 33 years' duration, severe carpal tunnel syndrome, and subclinical heart disease was treated with bromocriptine mesylate. Within eight months of therapy, basal growth hormone (GH) levels decreased from 90.0 to 7.0 ng/mL, and hand volume was reduced from 375 to 295 mL. Concomitantly, echocardiographic studies showed normal left ventricular size and function. Electromyographic studies demonstrated normal function in both median nerves. Bromocriptine may correct cardiac dysfunction and carpal tunnel syndrome in acromegaly either by reduction of GH oversecretion or by a direct effect of bromocriptine on dopamine receptors in the heart and peripheral nerve endings. (<i>JAMA</i>244:1825-1827, 1980)
SPATIAL QRS-T ANGLE PREDICTS MORTALITY IN CHRONIC DIALYSIS PATIENTS
Authors: Mihaly K. de Bie, Elsbeth Belt, Andre Gaasbeek, Roderick W.C. Scherptong, Cees A. Swenne, Martin J. Schalij, Ton J. Rabelink, J. Wouter Jukema
Journal: Journal of the American College of Cardiology (2010)
THE IMPACT OF THE FIFA 11+ ON THE STRUCTURE OF SELECT TRUNK AND LOWER EXTREMITY MUSCLES IN ADOLESCENT FEMALE FOOTBALLERS
Authors: J Whittaker, CA Emery
Journal: British Journal of Sports Medicine (2014)

Background The FIFA 11+ is an injury prevention program found to reduce lower-extremity injury risk; however, the mechanisms behind this protective effect are not well understood. One possible explanation is the program addresses trunk and lower-extremity muscle deficits. Objective To determine the impact of FIFA 11+ exposure on the structure of select muscles in adolescent female footballers. Setting Sport Medicine Clinic. Design Sub-study embedded within a cluster-randomized controlled trail (RCT). Participants 23 female footballers (14–16 years) recruited from three teams that participated in a FIFA11+ implementation strategies RCT. Intervention: Participants were recruited from teams randomly assigned to one of two FIFA 11+ delivery groups; coach with unsupervised website access (control; n=11) or, coach with pre-season FIFA 11+ workshop and on-field physiotherapist supervision (comprehensive; n=12). Main outcome measurements Pre-post season bilateral sonographic measures of: resting Rectus Abdominis (RA), External/Internal Oblique, Transversus Abdominis, Lumbar Multifidus (MF), Gluteus Medius/Minimus (GMd/GMn), and Vastus Mediallis (VM) thickness; VM width and inter-recti distance (IRD); change in abdominal parameters during an Active Straight Leg Raise (ASLR) and gluteals during hip abduction. Mean (95% CI) pre-post season changes in sonographic parameters were calculated and group means compared with paired t-tests (=0.05). Results No differences in 95% CIs existed for pre-post season change in sonographic parameters between participants with low (mean=149±9 exercises/year) and high (mean=314±15 exercises/year) FIFA 11+ exposure. Both groups exhibited significant within-group IRD decreases at rest (low t=8.20, P&lt;.001; high t=5.90, P&lt;.001) and with the ASLR (low t=5.66, P&lt;.001; high t=5.04, P&lt;.001). Further, the lower exposure group demonstrated decreased ASLR percent RA thickness change (t=3.19, P=.01) while the high exposure group exhibited increased resting MF thickness (t=2.26, P=.04). Conclusions Different levels of FIFA 11+ exposure in this investigation were not associated with differential changes in the structure of the muscles investigated. Protective mechanisms underlying the FIFA11+ may be associated with alterations in neuromuscular control resulting in IRD and MF adaptations.
Measles outbreak hits northeast England
Authors: J. Wise
Journal: BMJ (2013)

Northeast England has seen a serious outbreak of measles, with more than 100 confirmed or suspected cases and 29 patients needing hospital treatment.

The Health Protection Agency said that there had been 56 confirmed cases in the region and a further 49 suspected cases since the beginning of September last year. This compares with a total of 18 confirmed cases in 2011 and 11 cases in 2010.

Most of the cases are in unvaccinated schoolchildren and young adults, and immunisation officials are urging parents to ensure …
London whistleblower left with career in tatters
Authors: C. Dyer
Journal: BMJ (1999)

A former professor at Imperial College School of Medicine and consultant to the Hammersmith Hospitals NHS Trust, both in London, has been left with his career in tatters after raising concerns about the safety of patients.

Peter Dawson, aged 54, who has now talked openly in interviews with BBC Radio 4 and London's Evening Standard newspaper, was suspended from his job and eventually agreed to resign last February with a payoff of £120000 ($192000).

Dr Dawson, a consultant radiologist, is now on a six month contract with University College London hospitals which expires next month, …
VE_VC02 SLOPE IN HEART FAILURE PATIENTS DUE TO CHAGAS DISEASE IS AN INDEPENDENT PREDICTOR OF LONGTERM MORTALITY
Authors: Luiz Eduardo Fonteles Ritt, Antonio C. Carvalho, Gilson Feitosa, Cristiano Macedo, Fabio Vilas-Boas Pinto, Gilson Feitosa-Filho, Joel pinho, Renato Lopes
Journal: Journal of the American College of Cardiology (2012)
Premutation Alleles Associated With Parkinson Disease and Essential Tremor
Authors: Hao Deng, Weidong Le, Joseph Jankovic
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood Purification for Severe Sarin Poisoning After the Tokyo Subway Attack
Authors: Keitaro Yokoyama
Journal: JAMA (1995)

To the Editor.  —The terrorist attack using the nerve gas sarin that took place in the Tokyo subways on March 20, 1995, injured more than 5000 persons and caused 12 deaths. Two hundred thirty patients were seen at Toranomon Hospital. All of the patients were treated with 0.5 mg of intramuscular atropine sulfate, 10 mg of intravenous hydrocortisone, and 500 mL lactated Ringer's solution by intravenous drip. We encountered one patient with severe sarin poisoning who was resistant to this pharmacologic therapy, but whose condition significantly improved following blood purification.  A 45-year-old woman was brought to our hospital approximately 2 hours after the terrorist attack. On admission she was in a deep coma, had shallow respirations, and a blood pressure measurement of 160/80 mm Hg. Coarse crepitations were heard throughout both lung fields, and pupillary constriction (size of pupils, 1 mm in diameter) was observed. Chest radiography revealed severe pulmonary
Thrombotic Thrombocytopenic Purpura Associated with Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Authors: Andrea N. Leaf
Journal: Annals of Internal Medicine (1988)

The cases of 14 patients with thrombotic thrombocytopenic purpura admitted to one institution after 1980 were reviewed. Three of the fourteen cases occurred in patients with the acquired immunodeficiency syndrome (AIDS)-related complex and one occurred in a patient with probable human immunodeficiency virus (HIV) infection. The diagnosis in all four cases had been made after 1985. The association of thrombotic thrombocytopenic purpura with HIV infection was judged to be statistically significant on the basis of the proportion of patients with AIDS among the general population of patients admitted to the same institution during the same period. The fact that this association is only now being recognized suggests that there may be a long incubation period for thrombotic thrombocytopenic purpura or that the association is a rare one recognized now only because of the increased number of persons with AIDS.
Abuse of Medical Students
Authors: Larrie W. Greenberg
Journal: JAMA (1990)

<h3>To the Editor. —</h3> The recent articles and editorial on medical student abuse induced feelings of anxiety and déjà vu in me.<sup>1-3</sup>These studies, whatever their shortcomings, highlight an issue, recently addressed by Kanner in his book<i>Becoming a Doctor</i>,<sup>4</sup>that has been repressed too long. Unfortunately, the studies and editorial stopped short in recommending ways medical schools can change this environment. I would propose that the solution to this problem can be found in adopting and implementing sound educational principles in our medical schools. Historically, medical student abuse has been part of an educational tradition that dates back to apprenticeships before the establishment of medical schools in this country. To change this system is a monumental task that will require systematic, long-range, innovative planning and commitment initiated by our deans and influential department chairpersons. The power to suggest and help implement change rests at this level and
P191Mivrovascular damage, endothelium dysfunction and angiogenesis biomarkers as predictors of digital ulcers in systemic sclerosis
Authors: DR Silva, C Vasconcelos
Journal: Cardiovascular Research (2014)

Background: Digital Ulcers (DU) are a major disabling complication of SSc that interferes seriously with personal and professional life of our patients. The aim of this study was to correlate functional dysfunction of endothelium, capillaroscopy and angiogenesis biomarkers in patients with SSc in order to try to predict the development of digital ulcers in these patients. Methods: This is a prospective study of patients with Systemic Sclerosis (SSc) and primary Raynaud Phenomenon (RP) attending our Raynaud Clinic: n= 108. Demographic and epidemiological data, Flow mediated dilation (FMD) and end diastolic volume (EDV), capillaroscopy, Endothelin-1 (ET-1), ADMA, VEGF and Endoglin were analyzed and compared to a control group (n=31). Statistical calculations were performed using SPSS (v 20.0). Comparison and distribution between groups were performed using Kruskal-Wallis test. The Mann-Witney test was used to compare continuous variables wit nominal variables. A p value ≤ 0.05 was considered significant. Results: Flow mediated dilation (FMD) had statistical differences (P<0.001) between SSc patients with digital ulcers compared to SSc patients without DU or primary Raynaud phenomenon (RP). End diastolic volume was significantly different between groups (P<0.001) suggesting an increase in peripheral resistance in patients with DU. FMD was more reduced in patients with late pattern (Cutolo classification) in capillaroscopy and a statistical differences (P<0.001) between early and late pattern (P<0.007) was found. Endothelin-1 and ADMA were increased in patients with DU (P<0.001) which might explain an excessive vasoconstrictor tone in these patients in association with occlusion of distal digital circulation (avascular areas in capillaroscopy) leading to the reduced FMD in patients with DU. VEGF was increased in SSl patients without DU, we found no difference with primary RP (P<0.168). A statistical differences (P<0.002) between patients with DU and SSc patients with no DU or with primary RP was found in VEGF. Endoglin was increased in patients with DU (p<0,001). Patients with Cutolo late pattern in capillaroscopy had a increase in the angiostatic biomarker endoglin in comparison with the other groups (p<0,005). Conclusion: In our study , patients with antibody Sscl 70 positive, decreased FMD and low EDV, late pattern of Cutolo classification, increased ET-1, ADMA and endoglin and a reduced VEGF were at higher risk of developing digital ulcers.