tbuckley/cabot-search huggingface dataset:
Infections Complicating Cortisone Therapy
Authors: Frank P. Smith, E. A. Cleve
Journal: New England Journal of Medicine (1957)

ONE of the most serious complications of cortisone therapy is infection. In the six years in which cortisone has been available for general use, this danger has been the subject of numerous clinical and experimental reports. However, much of the enthusiastic literature has not given this aspect sufficient emphasis. The purpose of this report is to present 6 cases seen in a period of one year in which infections developed during cortisone therapy. Four of these infections were due to bacteria, 1 to monilia, and 1 to histoplasmosis.The corticosteroids are used in a wide variety of diseases, but their . . .
Sublingual immunotherapy in the treatment of children
Authors: N. Pham‐Thi, J. De Blic, P. Scheinmann
Journal: Allergy (2006)

Children with controlled intermittent mild‐to‐moderate asthma, controlled rhinitis and a single sensitivity may be appropriate candidates for sublingual immunotherapy (SLIT). Positive effects of SLIT may depend on initiation in early childhood and a long duration of treatment. To ensure optimum compliance, sociological, economic and familial factors should also be taken in to consideration when prescribing SLIT. Evidence from recent long‐term trials indicates that SLIT interfered with the atopic march and the allergic progression from rhinitis to asthma without any severe adverse side effects. Local immune response has been seen to be blunted with SLIT, which suggests that treatment has an immunomodulatory effect. In addition, it may also decrease the risk of new sensitizations. Ongoing developments in SLIT, particularly advances in dosing and new indications, such as food allergies, will increase the use of this treatment modality in children.
812-4 Efficacy of Angioscopic Findings for Prediction of Cardiac Events In Patients with Chronic Ischemic Heart Disease
Authors: Takayuki Miatke, Ko Arakawa, Kimio Satamura, Hirakuni Etsuda, Katsuhira Kitamura, Tomoo Nagai, Toshio Shibuya, Kajushige Isojima, Akira Kurita, Haruo Nakamura, Kyoichi Mizuno
Journal: Journal of the American College of Cardiology (1995)
Viral Infections and the Development of Asthma
Authors: Fernando D. Martinez
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The possible role of viral infections in the inception of asthma has been the matter of considerable debate. Older data suggested that viral respiratory infections occurring during early life could alter the lungs and the immune system, thus starting the process leading to allergic sensitization and persistent bronchial responsiveness. More recent studies suggest that infants who wheeze belong to two distinct groups, which at present can only be differentiated by the evolution of their illness. Most of these infants have a transitory tendency to wheeze during viral infections, and their lung function shortly after birth is significantly lower than that of infants who will not wheeze during similar infections. Most of these children become symptom-free during the preschool years, and their condition is not associated with higher serum IgE levels. A smaller group of children who wheeze as infants will still have wheezing episodes during the early school years. The factors that determine which infants will become persistent wheezers are not well understood, but viral infections per se are likely to play a minor role, if any. Early sensitization to aeroallergens in subjects genetically predisposed to having high serum IgE levels seems to be the main risk factor for this condition.
Accumulation of Bone Scanning Agent in Multiple Myeloma
Authors: MAYNARD L. FREEMAN, MARC VanDRUNEN, GREGORY GERGANS, ERVIN KAPLAN
Journal: Clinical Nuclear Medicine (1984)

FREEMAN, MAYNARD L. M.D.; VanDRUNEN, MARC M.D.; GERGANS, GREGORY M.D.; KAPLAN, ERVIN M.D. Author Information
Simultaneous isolation and detection of circulating tumor cells with a microfluidic silicon-nanowire-array integrated with magnetic upconversion nanoprobes
Authors: Chao Wang, Min Ye, Liang Cheng, Rui Li, Wenwen Zhu, Zhen Shi, Chunhai Fan, Jinkang He, Jian Liu, Zhuang Liu
Journal: Biomaterials (2015)
AORTIC DISSECTION DURING PREGNANCY: RESULTS FROM THE INTERNATIONAL REGISTRY OF ACUTE AORTIC DISSECTION (IRAD)
Authors: Alan C. Braverman, Kevin Harris, Reed Pyeritz, Stuart Hutchison, Linda Pitler, Arturo Evangelista, Magnus Larsen, Jane Humphrey, Andrea Bullinger, Matthias Voehringer, Patrick O&apos;Gara, Toru Suzuki, Christoph Nienaber, Eric Isselbacher, Kim Eagle
Journal: Journal of the American College of Cardiology (2012)
The Cancer Survivors and How They Did It
Authors: John M. Merrill
Journal: JAMA (1984)

As an acknowledged member of   orthodoxy, my attempt to review fairly a book that seeks to be controversial may be inadequate. Controversy demands either balanced presentations or startling new information, and this book lacks both. Unbalanced from its foreword (by a psychiatrist practicing oncology with l-mandelonitrile-β-glucuronic acid) to its conclusion,  book does at least avoid  classic polemic that states that there's a conspiracy to hide cancer cures.  Actual errors are few, and usually demonstrate a lack of understanding of  technical aspects of radiotherapy or cytotoxic chemotherapy. The author is somewhat naive in her review of research data. She readily accepts as scientific fact either casual observance or medical research by dentists or Nobel prizewinners in nonmedical fields. She is similarly generous in accepting as data testimonials, some of which are decades old.  The book attempts to be inspirational, in presenting  value of the will
Response to Comment on Goldfine et al. Targeting Inflammation Using Salsalate in Patients With Type 2 Diabetes: Effects on Flow-Mediated Dilation (TINSAL-FMD). Diabetes Care 2013;36:4132–4139
Authors: Allison B. Goldfine, Kathleen A. Jablonski, Steven E. Shoelson, Mark A. Creager
Journal: Diabetes Care (2014)

In our study to target inflammation using salsalate in patients with type 2 diabetes, we demonstrate improvement in glycemia but no change in either flow-mediated, endothelium-dependent (FMD) or nitroglycerin-mediated, endothelium-independent dilation over 6 months in salsalate (3.5 g/day) compared with placebo-treated patients (1). It is important to note that no adverse cardiovascular safety signal for endothelial function was demonstrated. Our findings differ from Pierce and colleagues (2,3), who demonstrated improvement in vascular function and …
TRUNK MOTION AND MUSCULAR STRENGTH AFFECT KNEE VALGUS MOMENT DURING SINGLE-LEG LANDING AFTER OVERHEAD STROKE IN BADMINTON
Authors: Y Kimura, E Tsuda, Y Hiraga, S Maeda, S Sasaki, E Sasaki, Y Fujita, Y Ishibashi, M Makino
Journal: British Journal of Sports Medicine (2014)

Background Anterior cruciate ligament (ACL) injury in knees opposite to the racket-hand side frequent occurs during single-leg landing after overhead stroke in badminton. Although large lateral inclination of trunk during single-leg landing seems to generate knee valgus moment which causes ACL injury, it has not been examined. Objective To evaluate if there was a correlation between trunk kinematics and knee valgus moment during single-leg landing after overhead stroke, in addition, to evaluate an association with muscular strength of trunk. Design Controlled laboratory study. Setting Female college badminton players with no history of knee injury. Participants 8 right-handed players. Risk factor assessment Subjects performed single-left-legged landing after an overhead stroke following back-stepping. The kinematic and kinetic data of the trunk and left lower extremity during landing were measured using 3-dimensional motion analysis system. Isometric trunk flexion and extension strength was measured using a dynamometer. Main outcome measurement Change in lateral trunk bending angle and maximum knee valgus moment during landing were measured. The correlation between these and trunk strength were analyzed. Results The average of maximum knee valgus moment was 0.34±0.24 Nm/kg/m, and the change in lateral trunk bending angle was 22.9±13.3 degrees, respectively. The mean trunk flexion strength was 2.2±0.9 Nm/kg. The knee valgus moment was significantly correlated with the change in lateral trunk bending angle (r=0.87, P&lt;.05) and the trunk flexion strength (r=−0.94, P&lt;.01). The change in lateral trunk bending angle was also significantly correlated with the trunk flexion strength (r=−0.94, P&lt;.01). Conclusions Larger lateral trunk bending associated with weak flexion strength increased knee valgus moment during single-leg landing. The core muscle training focused on trunk flexion strength may improve neuromuscular control of trunk and avoid excessive knee valgus moment in playing badminton, and this may play an important role of ACL injury prevention.
Campylobacter Enteritis in Iceland
Authors: ÓLAFUR STEINGRÍMSSON
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 August 1982Campylobacter Enteritis in IcelandÓLAFUR STEINGRÍMSSON, M.D., GUONI ALFREOSSON, M.D.ÓLAFUR STEINGRÍMSSON, M.D.Search for more papers by this author, GUONI ALFREOSSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-2-283_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The reports (1,2) of the Campylobacter enteritis outbreak in Bennington, Vermont, prompted us to look for Campylobacter in the water supply of Akranes, Iceland. In June 1980 we diagnosed Campylobacter enteritis in a resident (3) who did not have any known contact with a likely source of infection.Akranes is a small town of 5200 inhabitants that receives most of its drinking water from a river that drains an uninhabited valley. The valley is a major nesting ground for seagulls and grassland for sheep in summer. A small part of the town's water comes from wells. The...References1. . Waterborne Campylobacter gastroenteritis—Vermont. Morbid Mortal Weekly Rep. 1978;27:207. Google Scholar2. VOGTSOURSBARRETTFELDMANDICKINSONWITHERELL RHTRRL. Campylobacter enteritis associated with contaminated water. Ann Intern Med. 1982;96:292-6. LinkGoogle Scholar3. STEINGRÍMSSONKOLBEINSSON #A. Campylobacter jejuni. Algeng orsök niourgangs á Íslandi? Læknablaoio. 1981;67:73-6. Google Scholar4. KNILLSUCKLINGPEARSON MWA. Environmental isolation of heat-tolerant Campylobacterin the Southampton area [Letter]. Lancet. 1978;2:1002-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Iceland Reykjavík, Iceland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe impact of domestic travel on estimating regional rates of human campylobacteriosisCampylobacter ssp. Infections in Iceland during a 24-Month Period in 1980–1982: Clinical and Epidemiological Characteristics 1 August 1982Volume 97, Issue 2Page: 283-284KeywordsCampylobacterEnteritisRivers Issue Published: 1 August 1982 PDF downloadLoading ...
The Generation Gap
Authors: Leonard B. Berman
Journal: JAMA (1981)

Difficulty arises when young people in nursing, who are in the middle of a self-image revolution, meet older physicians who are unaware, indifferent, or hostile, in varying degrees. One need only scan recruiting ads in nursing journals to see that graduating nurses are being appealed to as glamorous, sophisticated, and intelligent members of the health care team. Beyond the "hype," however, is a serious movement in nursing to provide education credentials up to and beyond a master's degree, and to establish nurses as separate but equal health care professionals. Young nursing school graduates, having been provided with this view of themselves, enter the hospital world and collide with physicians who see nurses as none of the above. Instead, depending to some extent on their age, physicians may perceive nurses as handmaidens, drudges, or coffee pourers, on whom they may vent annoyance with the laboratory and x-ray; or they may perceive
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis
Authors: Monique F. Smeets, Elisabetta DeLuca, Meaghan Wall, Julie M. Quach, Alistair M. Chalk, Andrew J. Deans, Jörg Heierhorst, Louise E. Purton, David J. Izon, Carl R. Walkley
Journal: Journal of Clinical Investigation (2014)

Mutations within the gene encoding the DNA helicase RECQL4 underlie the autosomal recessive cancer-predisposition disorder Rothmund-Thomson syndrome, though it is unclear how these mutations lead to disease. Here, we demonstrated that somatic deletion of Recql4 causes a rapid bone marrow failure in mice that involves cells from across the myeloid, lymphoid, and, most profoundly, erythroid lineages. Apoptosis was markedly elevated in multipotent progenitors lacking RECQL4 compared with WT cells. While the stem cell compartment was relatively spared in RECQL4-deficent mice, HSCs from these animals were not transplantable and even selected against. The requirement for RECQL4 was intrinsic in hematopoietic cells, and loss of RECQL4 in these cells was associated with increased replicative DNA damage and failed cell-cycle progression. Concurrent deletion of p53, which rescues loss of function in animals lacking the related helicase BLM, did not rescue BM phenotypes in RECQL4-deficient animals. In contrast, hematopoietic defects in cells from Recql4Δ/Δ mice were fully rescued by a RECQL4 variant without RecQ helicase activity, demonstrating that RECQL4 maintains hematopoiesis independently of helicase activity. Together, our data indicate that RECQL4 participates in DNA replication rather than genome stability and identify RECQL4 as a regulator of hematopoiesis with a nonredundant role compared with other RecQ helicases.
Will one stage and no feedback suffice in lexicalization?
Authors: Trevor A. Harley
Journal: Behavioral and Brain Sciences (1999)

I examine four core aspects of weaver++. The necessity for lemmas is often overstated. A model can incorporate interaction between levels without feedback connections between them. There is some evidence supporting the absence of inhibition in the model. Connectionist modelling avoids the necessity of a nondecompositional semantics apparently required by the hypernym problem.
Tick Paralysis
Authors: Michael Cherington, Russell D. Snyder
Journal: New England Journal of Medicine (1968)

TICK paralysis is an ascending flaccid paralysis caused by the bite of a tick and cured by removal of the tick.We recently had the opportunity to examine a five-year-old girl with tick paralysis and to perform nerve-conduction studies. After reviewing the literature, we believe this to be the first case of tick paralysis in which conduction studies have been reported.Case ReportA 5-year-old girl from western Colorado was in excellent health until May, 1967, when, within a 2-day period, a progressive, ascending quadriparesis developed. Speech became indistinct, and she had trouble swallowing. She was hospitalized elsewhere, and an . . .
&lt;emph type="ital"&gt;The Physician Hua Tuo Scraping the Bone of Guan Yu to Treat an Arrow Wound&lt;/emph&gt;
Authors: Robert M. Golub
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.
Authors: E Bonora, G Targher, M Alberiche, R C Bonadonna, F Saggiani, M B Zenere, T Monauni, M Muggeo
Journal: Diabetes Care (2000)

OBJECTIVE: To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans. RESEARCH DESIGN AND METHODS: In the present study, we compared insulin sensitivity as assessed by a 4-h euglycemic (approximately 5 mmol/l) hyperinsulinemic (approximately 300 pmol/l) clamp with HOMA in 115 subjects with various degrees of glucose tolerance and insulin sensitivity. RESULTS: We found a strong correlation between clamp-measured total glucose disposal and HOMA-estimated insulin sensitivity (r = -0.820, P&amp;lt;0.0001), with no substantial differences between men (r = -0.800) and women (r = -0.796), younger (aged &amp;lt;50 years, r = -0.832) and older (r = -0.800) subjects, nonobese (BMI &amp;lt;27 kg/m2, r = -0.800) and obese (r = -0.765) subjects, nondiabetic (r = -0.754) and diabetic (r = -0.695) subjects, and normotensive ( r = -0.786) and hypertensive (r = -0.762) subjects. Also, we found good agreement between the two methods in the categorization of subjects according to insulin sensitivity (weighted k = 0.63). CONCLUSIONS: We conclude that the HOMA can be reliably used in large-scale or epidemiological studies in which only a fasting blood sample is available to assess insulin sensitivity
Intergenerational 20 year trends in the prevalence of asthma and hay fever in adults: the Midspan family study surveys of parents and offspring
Authors: M. N Upton
Journal: BMJ (2000)

<h3>Abstract</h3> <b>Objective:</b> To estimate trends between 1972–6 and 1996 in the prevalences of asthma and hay fever in adults. <b>Design:</b> Two epidemiological surveys 20 years apart. Identical questions were asked about asthma, hay fever, and respiratory symptoms at each survey. <b>Setting:</b> Renfrew and Paisley, two towns in the west of Scotland. <b>Subjects:</b> 1477 married couples aged 45–64 participated in a general population survey in 1972-6; and 2338 offspring aged 30–59 participated in a 1996 survey. Prevalences were compared in 1708 parents and 1124 offspring aged 45-54. <b>Main outcome measures:</b> Prevalences of asthma, hay fever, and respiratory symptoms. <b>Results:</b> In never smokers, age and sex standardised prevalences of asthma and hay fever were 3.0% and 5.8% respectively in 1972-6, and 8.2% and 19.9% in 1996. In ever smokers, the corresponding values were 1.6% and 5.4% in 1972–6 and 5.3% and 15.5% in 1996. In both generations, the prevalence of asthma was higher in those who reported hay fever (atopic asthma). In never smokers, reports of wheeze not labelled as asthma were about 10 times more common in 1972–6 than in 1996. With a broader definition of asthma (asthma and/or wheeze), to minimise diagnostic bias, the overall prevalence of asthma changed little. However, diagnostic bias mainly affected non-atopic asthma. Atopic asthma increased more than twofold (prevalence ratio 2.52 (95% confidence interval 1.01 to 6.28)) whereas the prevalence of non-atopic asthma did not change (1.00 (0.53 to 1.90)). <b>Conclusion:</b> The prevalence of asthma in adults has increased more than twofold in 20 years, largely in association with trends in atopy, as measured indirectly by the prevalence of hay fever. No evidence was found for an increase in diagnostic awareness being responsible for the trend in atopic asthma, but increased awareness may account for trends in non-atopic asthma.
Point: A Glucose Tolerance Test Is Important for Clinical Practice
Authors: Jaakko Tuomilehto
Journal: Diabetes Care (2002)

There is no doubt that clinical, symptomatic diabetes is a risk factor for cardiovascular disease (CVD) and all-cause mortality. It has also been shown that the risk is graded across the entire range of hyperglycemia (1,2). However, it has been debated during the last decades whether asymptomatic, unrecognized diabetes, or even a lesser degree of hyperglycemia, increases the risk of CVD and death. Traditionally, investigators who studied the association between hyperglycemia and the development of diabetic complications focused on fasting glucose levels (3). Until the 1980s, the standards for measuring blood glucose concentration varied, HbA1c was not available, and consequently, the results between the studies were conflicting. Now that we have data from the multitude of studies in which recommended standards have been applied (4,5), it has been possible to get a clearer picture of the matter. A plethora of recent studies from diverse populations have demonstrated that asymptomatic hyperglycemia is an independent risk factor (6–10).

Hyperglycemia, however, is not a simple issue. Blood glucose has a strong diurnal variation; it also varies seasonally and changes with age. Hyperglycemia can be determined at least in three ways by measuring fasting glucose, postchallenge (or postprandial) glucose, and HbA1c. The first is by definition the lowest glucose level during the day, during a few early morning hours. HbA1c indicates the mean glycemic level during a lengthy period of time—several weeks or months—summarizing both fasting and postprandial glucose levels. Postchallenge glucose level shows the magnitude of glucose elevation (peak) after the glucose load, lasting 1–3 h. If one eats the usual three meals a day, the postprandial glycemia usually lasts from 6 to 9 h a day (11). Even though there are moderate correlations between these parameters of glycemia, in the general …
Sigmar Gunar Norfried Saisch
Authors: M. Parry
Journal: BMJ (2011)

Born in Germany, Sigmar Gunar Norfried Saisch moved with his parents as very young boy to Australia, where he grew up. He gained his first degree, a BSc in physiology, before studying medicine and gaining his MB BS in 1982 at the University of Melbourne. He met Debbie and they moved to England, settling in London, where he completed an MSc in human and applied physiology at King’s College. He went on to work with Dr William Gardner and Professor Simon Wessely in the department of respiratory medicine at King’s, assessing and quantifying anxiety and …