Organophosphorus Esters and Polyneuropathy
Authors: MARTIN G. CHERNIACK
Journal: Annals of Internal Medicine (1986)

Editorials1 February 1986Organophosphorus Esters and PolyneuropathyMARTIN G. CHERNIACK, M.D., M.P.HMARTIN G. CHERNIACK, M.D., M.P.HSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-264 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptContaminated watermelons in California, toxic dumps and abandoned towns in the Midwest, and mass death in India: In the 1980s the hazards from human exposure to pesticides and related chemicals have moved from the toxicologic laboratory to the clinician's office. The muscarinic and nicotinic effects of one class of pesticides, the organophosphorus esters, have been well recognized for their acute inhibition of acetyl cholinesterase. There is also a less familiar but complex pattern of progressive and chronic polyneuropathy, organophosphorus-induced delayed neurotoxicity, which is a potentially devastating consequence of exposure to this ubiquitous class of substances found in industry and the...References1. JOHNSON M. The delayed neuropathy caused by some organophosphorus esters: mechanisms and challenge. CRC Crit Rev Toxicol. 1975;3:289-316. CrossrefMedlineGoogle Scholar2. CAVANAUGH J. Peripheral neuropathy caused by chemical agents. CRC Crit Rev Toxicol. 1973;2:365-417. CrossrefMedlineGoogle Scholar3. DAVISRICHARDSON CR. Organophosphorus compounds. In: SPENCER PS, SCHAUMBERG HH, eds. Experimental and Clinical Neurotoxicology. Baltimore: Williams & Wilkins; 1980:527-44. Google Scholar4. DRUG C. The system neurons affinity of triorthocresylphosphate. Brain. 1972;65:34-47. Google Scholar5. . Neurological findings among workers exposed to fenthion in a veterinary hospital—Georgia. MMWR. 1985;26:402-3. 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Delayed neurotoxicity of 0-ethyl-0-4-nitrophenyl, phenyl phosphonothionate: subchronic (90 days) oral administration in the hen. Toxicol Appl Pharmacol. 1978;45:685-700. CrossrefMedlineGoogle Scholar18. JOHNSON M. Delayed neurotoxic action of some organophosphorus compounds. Br Med Bull. 1969;25:231-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of California Irvine Medical Center Orange, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOrganophosphorus-Induced Delayed NeuropathyChemical TerrorismLess Common Causes of Quadriparesis and Respiratory FailureDelayed Neuropathy and Myelopathy after Organophosphate IntoxicationOrganophosphorus-Induced Delayed NeuropathyPesticidesBiochemical Changes Associated with Muscle Fibre Necrosis after Experimental Organophosphate PoisoningNeurological aspects of organophosphate poisoningNeurotoxicity of acute and repeated treatments of tabun, paraoxon, diisopropyl fluorophosphate and isofenphos to the henOverview of the biological and clinical aspects of organophosphates and carbamatesPesticide-Related Health Problems and FarmworkersLate onset isofenphos neurotoxicity. 1 February 1986Volume 104, Issue 2Page: 264-266KeywordsResearch laboratories Issue Published: 1 February 1986 PDF DownloadLoading ...