tbuckley/cabot-search huggingface dataset:
Marked Bladder Displacement by Dilated Rectosigmoid Colon
Authors: ANITA CHEVRES, STEVEN J. BROWN, WALTER J. SLIZOFSKI, LALITHA KRISHNA, REGINA ROMAN, SIMIN DADPARVAR
Journal: Clinical Nuclear Medicine (1993)

A 22-year-old man admitted to the hospital after blunt trauma to the head, neck, flank, and abdomen developed sickle cell crisis, Escnerichia coli sepis, tooth abscesses, and pain in his back and shoulders. Initial examination disclosed a massively dilated colon. A whole-body bone scan and a CT scan of the abdomen and pelvis were performed. Tc-99m HDP delayed bone images demonstrated abnormal uptake in multiple sites and a markedly displaced bladder, which emptied after voiding. The CT scan of the pelvis revealed a dilated stool-filled rectosigmoid displacing the bladder and loops of bowel. The patient refused further evaluation of the dilated colon, which emptied after multiple enemas. He was discharged after treatment for sickle cell crisis, sepsis, and tooth extractions.
Transient Diabetes Associated With Withdrawal of Lithium Therapy
Authors: O. E. Okosieme
Journal: Diabetes Care (2006)

We describe a patient with bipolar disease who developed diabetic ketoacidosis following discontinuation of long-term lithium treatment. Diabetes resolved completely after 7 months of insulin therapy. Transient diabetes in this patient could have been precipitated by withdrawal of lithium therapy.

A 26-year-old white male was admitted to our hospital with vomiting and abdominal pain. He suffered from bipolar disorder and had been on lithium treatment for 3 years. Six weeks before presentation, he had discontinued lithium due to persistent tremors and 2 weeks afterward developed excessive thirst …
AN ANALYSIS OF A SERIES OF CASE RECORDS RELATIVE TO CERTAIN PHASES OF BREAST FEEDING
Authors: HENRY DIETRICH
Journal: JAMA (1922)

This analytic study is based on a series of 1,000 records of almost consecutive cases seen in private practice. Hospital and welfare records are purposely omitted because I wish to demonstrate what happens to the infant of the middle class of our population. These patients employed a physician to care for mother and child during and, frequently, also after the obstetric period. Most mothers and nurslings are, and should be, cared for by the general practitioner. If we approach the subject from this practical standpoint, the general practitioner, whom I shall speak of as the obstetrician, must be impressed with the fact that he is constantly responsible for two patients, the mother and the child. Once imbued with this fact, he should aim to become as proficient in the care of the nursling, in all phases of its welfare, as he is in the care of the mother. The obstetrician must
Lipid infusion lowers sympathetic nervous activity and leads to increased β-cell responsiveness to glucose
Authors: Christophe Magnan, Stephan Collins, Marie-France Berthault, Nadim Kassis, Mylène Vincent, Marc Gilbert, Luc Pénicaud, Alain Ktorza, Françoise Assimacopoulos-Jeannet
Journal: Journal of Clinical Investigation (1999)

We investigated the possible involvement of the autonomic nervous system in the effect of a long-term elevation of plasma free fatty acid (FFA) concentration on glucose-induced insulin secretion (GIIS) in rats. Rats were infused with an emulsion of triglycerides (Intralipid) for 48 hours (IL rats). This resulted in a twofold increase in plasma FFA concentration. At the end of infusion, GIIS as reflected in the insulinogenic index (ΔI/ΔG) was 2.5-fold greater in IL rats compared with control saline-infused rats. The ratio of sympathetic to parasympathetic nervous activities was sharply decreased in IL rats relative to controls. GIIS was studied in the presence of increasing amounts of α- and β-adrenoreceptor agonists and antagonists. The lowest concentrations of the α2A-adrenoreceptor agonist oxymetazoline, which were ineffective in control rats, reduced GIIS in IL rats. At the dose of 0.3 pmol/kg, GIIS became similar in IL and control rats. The use of β-adrenoreceptor agonist (isoproterenol) or antagonist (propranolol) did not result in a significant alteration in GIIS in both groups. GIIS remained as high in IL vagotomized rats as in intact IL rats, indicating that changes in parasympathetic tone were of minor importance. Altogether, the data show that lipid infusion provokes β-cell hyperresponsiveness in vivo, at least in part through changes in α2-adrenergic innervation.
Impotence in Scleroderma
Authors: NANCY S. NOWLIN
Journal: Annals of Internal Medicine (1986)

Hormonal, neurologic, and vascular factors affecting potency were evaluated in 10 men with scleroderma and in 10 age-matched men with rheumatoid arthritis. Impotence was reported by 6 of the patients with scleroderma and none with rheumatoid arthritis. Studies of serum testosterone, free testosterone index, follicle-stimulating hormone, luteinizing hormone, prolactin, estradiol, thyroxine, and thyrotropin did not show a hormonal basis for impotence in any patient. Neurologic causes were not found on physical examination. Penile blood pressures were markedly abnormal in 4 impotent patients, intermediate in 2 impotent and 3 potent patients, and normal in 11 potent patients. A history of claudication and diminished ankle blood pressures indicated large vessel disease in 2 impotent patients; the remaining 4 impotent men had normal ankle pressures, suggesting that their poor penile blood pressures and impotence were due to small vessel disease, perhaps the small artery lesions of scleroderma.
Accessing Maternal Health Services in Eastern Burma
Authors: Macaya Douoguih
Journal: PLoS Medicine (2008)

Burma is a country that has endured decades of war and civil conflict. The State Peace and Development Council, the current military regime that has governed the country for decades, has had ongoing conflicts with ethnic minority groups. Specific policies of the State Peace and Development Council have resulted in forced labor, forced relocation, torture, killings, and deliberate destruction of food supplies [1–3], largely targeted at ethnic minorities within the country [4]. Over one million Burmese are estimated to have been displaced since 1996 [5], and about half have been unable to resettle or return to their homes. The eastern border of the country bears the largest burden of internally displaced persons in the country [5].

Accurate measures of health are critical to address the high morbidity and mortality in this vulnerable population. However, there is a wide variation in reported estimates of health indicators. For example, the World Health Organization reports a maternal mortality ratio of 360 per 100,000 live births [6]; in 2006 UNICEF reported an under-five mortality rate of 104 per 1,000 live births and an infant mortality rate of 74 per 1,000 live births [7]. In contrast, surveys conducted by the Back Pack Health Worker Team—a community-based organization providing health care to internally displaced persons in active conflict zones (“black zones”)—give very different results. The team's surveys estimate maternal mortality as 1,000–1,200 per 100,000 live births [4] and infant mortality and under-five mortality as 91 per 1,000 live births and 221 per 1,000 live births, respectively [4].

Linked Research Article
This Perspective discusses the following new study published in PLoS Medicine:

Mullany LC, Lee CI, Yone L, Paw P, Oo EKS, et al. (2008) Access to essential maternal health interventions and human rights violations among vulnerable communities in eastern Burma. PLoS Med 5(12): e242. doi:10.1371/journal.pmed.0050242

Luke Mullany and colleagues examine access to essential maternal health interventions and human rights violations within vulnerable communities in eastern Burma.
Abstract 4892: Hypoxia enhances tumor vascularization by endothelial differentiation of endometrial cancer stem cells.
Authors: Mitsuhiro Nakamura, Xiuzhi Zhang, Masahiro Takakura, Yoshiko Maida, Yasunari Mizumoto, Yukiko Bono, Toshiyuki Sasagawa, Satoru Kyo
Journal: Cancer Research (2013)

Abstract Emerging evidence has shown that a small subpopulation of cancer cells plays critical roles in tumorigenesis, establishing the cancer stem cells (CSCs) theory. CSCs have properties of tumorigenesis, self-renewal and multilineage differentiation. Previous our study demonstrated that CD133+ enodometrial cancer cells showed tumorigenic and self-renewal ability, suggesting that CD133 was a potential CSC marker in endometrial cancer. In this study, we focused on multilineage differentiation and investigated an ability of endothelial differentiation in endometrial CSCs. Immunohistochemistry of subcutaneous xenografts showed that human endometrial tumors contained human vessels labeled by human-specific anti-CD31 and vWF antibodies. Endothelial tube formation assay (in vitro angiogenesis) revealed that isolated CD133+ endometrial cancer cells could show tube formation while CD133- cells could not. CD133+ cells expressed CD31 and VEGFR-1 higher than CD133- cells. In some cell types of endometrial cancer cells, flow cytometric analysis showed expression of CD31 was high ratio under hypoxia compared to normoxia. Furthermore, in vitro angiogenesis assay demonstrated hypoxic condition could promote and keep tube formation in CD133+ cells, but not CD133- cells. These results suggest that CSCs have potential of endothelial differentiation and hypoxia enhances endothelial differentiation of CSCs. These findings shed light on the establishment of new target therapy for endometrial cancer. Citation Format: Mitsuhiro Nakamura, Xiuzhi Zhang, Masahiro Takakura, Yoshiko Maida, Yasunari Mizumoto, Yukiko Bono, Toshiyuki Sasagawa, Satoru Kyo. Hypoxia enhances tumor vascularization by endothelial differentiation of endometrial cancer stem cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4892. doi:10.1158/1538-7445.AM2013-4892
Solitary plasmacytoma of the uvula
Authors: Frank G. Basile, Min Shi, Molly Sullivan
Journal: American Journal of Hematology (2014)

A 64-year-old gentleman presented to an otolaryngologist complaining of feeling a foreign body in his throat for several weeks. He had no pain, no dysphagia, nor odynophagia. In general, he was in good health. On physical exam, a mass could be seen on the posterior aspect of the uvula in the oropharynx (Image 1). A biopsy surprisingly revealed a plasmacytoma, composed of sheets of atypical plasma cells expressing CD56 and CD138 (Image 2). The patient underwent a complete evaluation for plasma cell dyscrasia. Serum electrophoresis with immunofixation revealed a minute lambda band too small to quantify. A 24 hr urine immunofixation revealed no monoclonal proteins. Other studies included normal free serum light chains (kappa-1.06 mg/dL, lambda 1.16 mg/dL ratio 0.9138), Hgb 15.7 g/dL, erythrocyte sedimentation rate 5 MM/hr, Cre 1.13 mg/dL, Albumin 4.3 g/dL, Calcium 9.2 mg/dL. A bone marrow core biopsy and aspirate showed no increase in plasma cells and no evidence of a monoclonal plasma cell population. Skeletal Survey with standard X-rays showed no lytic bone lesions. The patient also underwent a PET-CT scan that showed only the solitary focus in the oropharynx with increased 18F-fluorodeoxyglucose uptake. An MRI of the head showed no other lesions in the nasopharynx or sinuses. Therefore, a diagnosis of Solitary Extraosseous Plasmacytoma (SEP) was made. Treatment consisted of 50Gy of radiation to the lesion on the soft palate and 42.5Gy to the first echelon draining lymph nodes, administered via intensity-modulated radiation therapy (IMRT) to limit toxicity to the parotid gland, sublingual glands, and oral cavity (Image 3). Six weeks postradiation, clinically the lesion had completely regressed, and serum immunofixation no longer detected a minute lambda band. Post treatment PET-CT was negative. He will continue ongoing serologic surveillance and direct laryngoscopy at 3 to 6 month intervals and will be followed indefinitely. In contrast to Osseous (Medullary) Solitary Plasmacytoma, which carries a ∼50% risk of eventually developing Multiple Myeloma, the risk of developing Multiple Myeloma in patients with SEP is lower, estimated at between 10 and 20%. SEP commonly involves the upper respiratory tract and oropharynx as in this case, and has been reviewed extensively 1-6. Currently, the standard treatment approach for SEP is definitive radiation therapy, with a dose of >45 Gy of radiation therapy to the lesion 1, 4. This results in local control rates of ∼90%. Radiation of regional draining lymph nodes has been recommended for lesions involving the soft tissues of the head and neck 2. Patients who continue to display a monoclonal gammopathy post radiation are considered higher risk for either local relapse or eventual evolution to Multiple Myeloma. All patients require close ongoing follow-up.
Hereditary Factors in Rheumatoid Arthritis and Ankylosing Spondylitis
Authors: J. J. de Blecourt, A. Polman, T. de Blecourt-Meindersma, T. J. D. Erlee, E. F. Drion
Journal: Annals of the Rheumatic Diseases (1961)

In determining the results of the subsequent examina- tion of the relatives of these 300 probands, the same criteria were used as regards a possible diagnosis of "rheumatoid arthritis" or "ankylosing spondylitis".Relatives.-Thecompletest possible pedigree was obtained for each of the 300 probands.All accessible grandparents, parents, siblings, children, and collateral members of the family were examined.215 copyright.
Unusual Neurological Complications After Sudden Withdrawal of Cortisone
Authors: A. G. Beckett, C. J. Stevenson
Journal: BMJ (1956)

no doubt borne by the profits reaped in consequence of its success.The British Medical Journlal (1954) has referred to the role of family doctors in dissuading mothers from the routine administration of unnecessary medicaments to their offspring.Both they and all health workers, especially those whose efforts are chiefly directed towards infants and children, must play their part in discouraging the regular use of laxatives and the attitude of mind which accompanies it. SummaryThe regular taking of laxatives by a group of school entrants and leavers is investigated.Over 17% of these children took them at least weekly, proportionately more girls than boys doing so at each age.The prac- tice was commoner among entrants than among leavers.The frequency of administration and type of laxative used are analysed.The undesirable nature of such medication is dis- cussed.
Back to the future (again)
Authors: S. A Spence
Journal: BMJ (1997)

Sean Spence finds contemporary psychiatry attempting to distance itself from the “cruelty” of the past in an exhibition commemorating 750 years of the Bethlem Royal Hospital. Bedlam: Custody, Care and Cure , can be seen at the Museum of London until 15 March 1998. 

The Museum of London is a densely packed menagerie, sequestered away in the labyrinthine Barbican area of the City of London. Currently, it hosts an exhibition commemorating 750 years of the Bethlem Royal Hospital, the world's oldest hospital for the mentally ill. The exhibition itself is an uneasy mix of the old and the new. In a darkened room display cases brim with exhibits culled from the Bethlem archives, augmented in places by those of the host museum. All the usual suspects are here: the brooding maniacal …
Diet and Asthma
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PREVENTION OF INFECTIOUS DISEASES.
Authors: J. M. G. CARTER
Journal: JAMA (1896)

Perhaps no branch of medicine occupies so much of the thought of the medical profession to-day as infectious diseases. The manner of dealing with these has undergone great changes during the, last few years.  The treatment is more satisfactory, and the prophylactic and preventive phases of treatment are most prominent. Since Jenner discovered the importance of vaccination as a preventive measure against smallpox the belief has prevailed in many minds, and hope in all, that some means might be discovered to reduce the terrors if not prevent the prevalence of all the diseases commonly known as infectious. Under improved hygienic precautions and more scientific methods of treatment this hope is beginning to be realized. Typhoid and malarial fevers are almost conquered, the specters of tuberculosis and diphtheria are beginning to pale and show evidences of vanishing, the terrible cases of scarlet fever are not so frequent, measleset al.are
High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: A double-blind, placebo-controlled study
Authors: Ulrich Wahn, Ludger Klimek, Anna Ploszczuk, Thomas Adelt, Bernhard Sandner, Ewa Trebas-Pietras, Peter Eberle, Albrecht Bufe
Journal: Journal of Allergy and Clinical Immunology (2012)
Acute Renal Failure Due to Heat Injury: An Analysis of Ten Cases Associated with a High Incidence of Myoglobinuria.
Authors: Robert M. Vertel
Journal: Annals of Internal Medicine (1967)

s1 May 1967Acute Renal Failure Due to Heat Injury: An Analysis of Ten Cases Associated with a High Incidence of Myoglobinuria.Robert M. Vertel, James P. KnochelRobert M. VertelSearch for more papers by this author, James P. KnochelSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1054_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA cute renal failure is generally considered to be a grave complication of heat injury. Since the report in 1958 of three fatal cases of acute renal failure and "atypical heat stroke" treated at the U. S. Army Surgical Research Unit, ten additional patients have been treated at this facility for oliguric renal failure due to heat injury. Seven of these patients had classical heat stroke and recovered without serious sequelae while another patient survived acute renal failure secondary to heat exhaustion. The remaining two demonstrated a prodromic behavior disorder, unaccompanied by obvious signs of heat injury, culminating in hyperpyrexia,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fort Sam Houston, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1054-1054KeywordsAcute renal failureBehaviorRenal analysisRenal failureStroke Issue Published: 1 May 1967 PDF DownloadLoading ...
Potential Risk of Asbestos Exposure Among Japanese General Population: Japanese General Screening Study for Asbestos-Related Diseases (JGSARD)
Authors: N. Seki, K. Eguchi, M. Kusumoto, M. Kaneko, T. Yamaguchi, F. lcli, D. Caliskan, I. Gonullu, H. Akbulut, A. Ozkan, S. Olmez, U. Gonullu, K. Sunguroglu, E. Walsh, M. Farrell, R. Clarke, C. Nolan, M.J. Kennedy, J.A. McCaffrey, E. Connolly, M. Kell, T. Boyle, D. Gallagher, S. Gupta, D. Avila, E.A. Mino, P. Gosain, K.K. Batra, S. McDunn, N.A. Zakharova, S.W. Duffy, J. Mackay, E.V. Kotlyarov, A.V. Filimonov, K. Barinov, I. Gromut, E.V. Belan, F. Eisinger, J. Viguier, C. Touboul, Y. Coscas, X. Pivot, J. Blay, C. Lhomel, J. Morère, S. Bhattacharjee, C.K. Bose, S. Koner, A. Mukhopadhyay, A.N. Sen, C. Guillen-Ponce, E. Mocci, A. Amendolara, E. Vazquez-Sequeiros, C. Gonzalez Gordaliza, M. Muñoz Beltran, A. Sanjuanbenito, C. Gonzalez Garcia, A. Custodio, A. Carrato, J. Basak, A. Chakraborty, S. Dasgupta, D. Bhattacharya, S. Mukhopadhyay, P. Hazra, O. Uysal Sonmez, U. Uyeturk, I.I. Budakoglu, R. Kazancioglu, I. Turker, B. Budakoglu, U. Yalcintas Arslan, O.B. Oksuzoglu
Journal: Annals of Oncology (2012)
The Relation Between the Community Hospital and the Medical Center
Authors: DONALD E. WARREN
Journal: Annals of Internal Medicine (1968)

Greater demands are being placed on the community hospital and the practicing physician by an increasing population, a more sophisticated public with increasing medical demands, and an ever increasing bulk of medical knowledge. Only by a closer cooperation among the medical center, the community hospital, and the practicing physician can we accomplish the aims of all three—namely, that of providing the best possible medical care for all people. Four areas in which there should be further study and closer cooperation are suggested. These include training physicians to see more people in a shorter period of time and yet improve the quality of the patient care, another level of physicians requiring different and much shorter training for routine medical care, and better continuing education as well as mechanisms to upgrade those physicians who are not prepared to take care of the seriously ill or complex patient.
880-2 Randomized comparison of rotational atherectomy and cutting balloon angioplasty followed by radiation therapy with a 188Re-MAG3-filled balloon in the treatment of diffuse in-stent restenosis
Authors: Seong-Wook Park, Seung-Whan Lee, Young-Hak Kim, Ki-Hoon Han, Cheol Whan Lee, Myeong-Ki Hong, Jae-Joong Kim, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2004)
ACROMEGALY OF THE LARYNX
Authors: CHEVALIER JACKSON
Journal: JAMA (1918)

The literature of acromegaly contains but little reference to the larynx, which seems strange in view of the fact that in a number of cases alteration of the voice is mentioned. I hope that the herein recorded cases will lead to systematic examination of the larynx not only in every case of acromegaly but also in every case of hypophysial abnormality. It is to call attention to the necessity for this that the four cases are reported. Complete reports of all the cases would require too much space and would detract from the emphasis desired to be placed on the laryngeal phases: <h3>REPORT OF cases</h3><h3>Case 1.—History.</h3> —A man, aged 43, complained of remittent shortness of breath of two years' duration. Breathing was noisy at night. Repeated "asthmatic" attacks culminated in a severe dyspneic attack two weeks before. A laryngologist arrived in time to do a tracheotomy and save