MRFIT, "MS FIT," and Alcohol Use
Authors: Michele G. Cyr, Anne W. Moulton, Michael D. Stein
Journal: Annals of Internal Medicine (1992)

Letters15 November 1992MRFIT, "MS FIT," and Alcohol UseMichele G. Cyr, MD, Anne W. Moulton, MD, Michael D. Stein, MDMichele G. Cyr, MD, Anne W. Moulton, MD, Michael D. Stein, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-10-874 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Suh and colleagues (1) report results from the Multiple Risk Factor Intervention Trial (MRFIT) suggesting that for light- to moderate-drinking middle-aged men, the inverse association between alcohol consumption and coronary heart disease mortality can be explained largely by increased high-density lipoprotein (HDL) levels. What is not stated explicitly is that these results should not be generalized from middle-aged men to women.Women differ from men, particularly concerning alcohol. What is considered light to moderate drinking for men is potentially hazardous for women. More specifically, the risk for alcohol-related morbidity begins to increase significantly at alcohol consumption above...References1. SuhShatenCutlerKuller IJJL. Alcohol use and mortality from coronary heart disease: the role of high-density lipoprotein cholesterol. Ann Intern Med. 1992;116:881-7. LinkGoogle Scholar2. CyrMoulton MA. Substance abuse in women. Obstet Gynecol Clin North Am. 1990;17:905-25. CrossrefMedlineGoogle Scholar3. FrezzaDiPadovaPozzatoTerpinBaraonaLieber MCGMEC. High blood alcohol levels in women: the role of decreased gastric alcohol dehydrogenase activity in first-pass metabolism. N Engl J Med. 1990;22:95-9. CrossrefGoogle Scholar4. SchatzinJonesHooverTaylorBrintonZiegler AYRPLR. Alcohol consumption and breast cancer in the epidemiologic follow-up study of the First National Health and Nutrition Examination Survey. N Engl J Med. 1987;316:1169-80. CrossrefMedlineGoogle Scholar5. FelsonKielAndersonKannel DDJW. Alcohol consumption and hip fractures: the Framingham Study. Am J Epidemiol. 1988;128:1102-10. CrossrefMedlineGoogle Scholar1. SuhShatenCutlerKuller IJJL. Alcohol use and mortality from coronary heart disease: the role of high-density lipoprotein cholesterol. Ann Intern Med. 1992;116:881-7. LinkGoogle Scholar1. SuhShatenCutlerKuller IBJL. Alcohol use and mortality from coronary heart disease: the role of high-density lipoprotein cholesterol. Ann Intern Med. 1992;116:881-7. LinkGoogle Scholar2. CriquiCowanTyrolerBangdiwalaHeissWallace MLHSGR. Lipoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: results from the Lipid Research Clinics Follow-Up Study. Am J Epidemiol. 1987;126:629-37. CrossrefMedlineGoogle Scholar3. Criqui M. The roles of alcohol in the epidemiology of cardiovascular disease. Acta Med Scand (Suppl). 1987;717:73-85. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rhode Island Hospital Brown University School of Medicine Providence, RI 02903 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1992Volume 117, Issue 10Page: 874-875KeywordsAddictionAlcohol consumptionAlcoholsCoronary heart diseaseHigh density lipoproteinMedical risk factorsMorbidityMortalityRisk management Issue Published: 15 November 1992 PDF downloadLoading ...