tbuckley/cabot-search huggingface dataset:
Abstract 1929: Antifolates as folate receptor targeting ligands: Design and synthesis of their conjugates with cytotoxic agents
Authors: Iontcho Vlahov, Fei You, Ryan Dorton, Elaine Westrick, Joseph Reddy, Christopher P. Leamon
Journal: Cancer Research (2012)

Abstract Antifolates are interfering specifically with DNA synthesis in the S-phase of the cell cycle. Thus, they are cytotoxic to rapidly dividing cancer cells, which replicate their DNA more frequently. Some antifolates bind with high affinity to the cell-membrane-associated folate receptor (FR). FR is frequently over-expressed in some of the most prevalent tumors. FR-binding antifolates can also be used as ligands for FR-targeted delivery of therapeutic agents. With this presentation we are reporting an improved synthesis of the FR-binding antifolate CB3717. Furthermore, to demonstrate its dual utility as FR-ligand and therapeutic agent, we designed and synthesized a conjugate of CB3717 with the highly cytotoxic agent Desacetylvinblastine Monohydrazide. A hydrophilic spacer unit and two biologically releasable disulfide-based linker systems were used to construct the conjugate. This conjugate exhibited high binding affinity for FR and excellent anti-tumor activity in vivo (subcutaneous FR+ KB tumors). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1929. doi:1538-7445.AM2012-1929
278 mTOR Inhibition for patients with hepatocellular carcinoma undergoing liver transplantation: Is there a rationale?
Authors: W. Sieghart, T. Fuereder, K. Schmid, D. Cejka, E. Wrba, X. Wang, D. Gruber, S. Rasoul-Rockenschaub, M. Peck-Radosavljevic, V. Wacheck
Journal: Journal of Hepatology (2006)
Latent Semantic Analysis (LSA), a disembodied learning machine, acquires human word meaning vicariously from language alone
Authors: Thomas K. Landauer
Journal: Behavioral and Brain Sciences (1999)

The hypothesis that perceptual mechanisms could have more representational and logical power than usually assumed is interesting and provocative, especially with regard to brain evolution. However, the importance of embodiment and grounding is exaggerated, and the implication that there is no highly abstract representation at all, and that human-like knowledge cannot be learned or represented without human bodies, is very doubtful. A machine-learning model, Latent Semantic Analysis (LSA) that closely mimics human word and passage meaning relations is offered as a counterexample.
Alcohol and the Borderline Personality
Authors: GREGORY E. BERGER
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 August 1982Alcohol and the Borderline PersonalityGREGORY E. BERGER, M.D.GREGORY E. BERGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-2-280_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: As a medical director of an alcoholism treatment center, I have a different perspective on the five case histories included in the article (1) on the borderline personality.The recurrent themes of labile personality changes, hostility, manipulation, defiance, marital problems, and physical ailments are characteristic of the untreated alcoholic. Regardless of the correct diagnosis, it is significant that none of the proposed management plans included aggressive therapy for alcoholism. Nor did the plans suggest reevaluating the diagnosis of borderline personality after a period of prolonged sobriety as a treatment stratagem.In an earlier article, Clark (2) suggested...References1. STOUDEMIRETHOMPSON AT. The borderline personality in the medical setting. Ann Intern Med. 1982;96:76-9. LinkGoogle Scholar2. CLARK W. Alcoholism: blocks to diagnosis and treatment. Ann J Med. 1981;71:275-86. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GREGORY E. BERGER, M.D.Affiliations: Sacred Heart Rehabilitation Center Detroit, MI 48201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1982Volume 97, Issue 2Page: 280-280KeywordsAlcoholicsAlcoholismAlcohols ePublished: 1 December 2008 Issue Published: 1 August 1982 PDF downloadLoading ...
Comparison of four right ventricular systolic echocardiographic parameters to predict adverse outcomes in chronic heart failure
Authors: Thibaud Damy, Caroline Viallet, Olivier Lairez, Guillaume Deswarte, Alexandra Paulino, Patrick Maison, Emmanuelle Vermes, Pascal Gueret, Serge Adnot, Jean‐Luc Dubois‐Randé, Luc Hittinger
Journal: European Journal of Heart Failure (2009)
P157 The Language of Cough: A Focus Group Study in Respiratory Diseases
Authors: SV Oliver, D Yuill, J Yorke, AL Caress, JA Smith
Journal: Thorax (2012)

<h3>Background</h3> Little is known about the sensations and triggers that provoke cough in patients, or their preferred language to describe their experiences. We have previously collected a list of descriptors covering the themes of triggers, sensations and secretions, generated from individual interviews in a range of respiratory disorders, with a view to developing a questionnaire. <h3>Aims</h3> To take the key descriptors and present these to focus groups diagnosed with chronic cough, COPD, ILD, asthma, and non-CF bronchiectasis. <h3>Methods</h3> Five semi-structured focus groups were conducted with 22 participants (7 chronic cough, mean age 67.7 years (range 57–80) 4 female; 5 asthma, age 66 years (60–71) 2 female; 4 COPD, age 68 years (66–73) 2 female; 3 ILD, age 70 years (65–74) 0 female; 3 non-CF bronchiectasis, age 67.3 years (53–77) 2 female). Using simple manifest content analysis, a list of descriptors was derived based on the frequency of use during individual interviews. These were presented to the focus groups, asking them to describe what each word meant to them, the image it conjured up and whether they could identify a most appropriate word. <h3>Results</h3> All focus groups favoured the terms ‘phlegm’ over ‘sputum’ (which was considered too “clinical”), ‘irritation’ over the word ‘tickle’ (which was considered too “gentle”) and the ‘need to cough’ over an ‘urge to cough’. In contrast, there were distinct differences in some disease groups for example, all groups, apart from COPD, recognised specific foods and eating as triggers of coughing. Similarly, all groups, apart from asthma, identified specific smells and odours as triggers of coughing. Patients with COPD, ILD and non-CF bronchiectasis related to the word ‘crackle’, but asthmatics only associated this word with “infection” and chronic cough patients did not identify with this terminology. <h3>Conclusion</h3> These focus group discussions would suggest that whilst some descriptors of cough are felt to be universally appropriate, other descriptors and triggers appear to discriminate between diagnoses. This study will inform the language and content of a future questionnaire to categorise patients by the sensations and triggers provoking their cough.
Rat hepatocyte aggregate formation on discrete aligned nanofibers of type-I collagen-coated poly(l-lactic acid)
Authors: Zhang-Qi Feng, Xue-Hui Chu, Ning-Ping Huang, Michelle K. Leach, Gan Wang, Yi-Chun Wang, Yi-Tao Ding, Zhong-Ze Gu
Journal: Biomaterials (2010)
DISEASES OF PORTO RICO
Authors: ELMER F. OTIS
Journal: JAMA (1913)

Porto Rico is an interesting island-gem forming an emerald setting of the crescent of the West Indies. The climatic and social conditions are such that the various diseases have no difficulty in making great headway, when permitted to pursue their natural course. It is about the diseases here encountered that I wish to speak. Manson has well said, "If by 'tropical diseases' be meant diseases peculiar to the tropics, then half a dozen pages might have sufficed for the description [for, at most, only two or three comparatively unimportant diseases strictly deserve that title]. If, on the other hand [the term] include all diseases occurring in the tropics, then the work would require to cover almost the entire range of medicine." <h3>TUBERCULOSIS, TYPHOID AND MALARIA</h3> Tuberculosis, typhoid and malaria may justly receive first mention; while rickets, bronchopneumonia, angina pectoris, venereal diseases, tumors, meningitis and a variety of chronic rheumatic
Justifying Patient Risks Associated With Medical Education
Authors: Winston Chiong
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The value of synovial fluid analysis in the assessment of knee joint destruction in arthritis in a three year follow up study
Authors: S Aman, J Risteli, R Luukkainen, L Risteli, M Kauppi, P Nieminen, M Hakala
Journal: Annals of the Rheumatic Diseases (1999)

To assess the predictive significance of synovial fluid (SF) analysis for progressive radiological knee joint destruction in arthritis.Altogether 55 patients with arthritis and knee joint effusion were included in the study. The diagnosis was rheumatoid arthritis (RA) for 44 of them, chronic seronegative spondylarthropathy for seven and juvenile rheumatoid arthritis for four. The mean age of the patients was 51.8 (SD 14.9, range 19-82) years, and the mean duration of disease 10.9 (SD 9.2, range 0.5-37) years. In addition to the routine laboratory tests, different markers of collagen synthesis and breakdown in serum and SF were assessed. The radiological grade of the knee joint was assessed by Larsen's method at the baseline and after a three year follow up.During the follow up, Larsen's grade deteriorated in 22 (40%) patients. These patients had a significantly higher median level of cross linked carboxyterminal telopeptide of type I collagen (ICTP) in SF at entry than those who had a stable index (p = 0.035). Serum ICTP did not have any predictive value for a specific joint. The median levels of total SF leucocytes (p = 0.012) and the subgroup of polymorphonuclear leucocytes (p = 0.018) were higher in the patients with a stable Larsen's index. However, the relation of SF leucocyte level to radiological progression could not be confirmed in the RA group.It is concluded that SF analysis may help in the identification of patients with inflammatory arthritis who are at risk for progressive destruction in a particular joint. A high total SF leucocyte level is not necessarily associated with a poor prognosis. Instead, a high SF ICTP level seems to reflect accelerated bone degradation.
A good surgeon should know when to abandon a procedure
Authors: Anuruddha M Abeygunasekera
Journal: BMJ (2006)

In my early days as a consultant I saw a patient with left upper abdominal pain and a lump in the loin. Abdominal ultrasonography in the 38 year old widow revealed a grossly hydronephrotic left kidney and a right pelvic kidney. An intravenous urogram showed some functioning renal tissue in the region of the upper sacrum corresponding to the pelvic kidney. The left kidney was not visualised. An isotope …
Neurogenic Control of Peripheral Resistance in Renal Hypertension
Authors: ALBERTO C. TAQUINI
Journal: Circulation Research (1963)

The increased peripheral resistance responsible for hypertension associated with unilateral renal ischemia and contralateral nephrectomy, is abolished after destruction by pithing of the central nervous system of dogs and rats, or after inactivation of the inhibitory carotid sinus reflex in dogs. The tissue catecholamine content of renal hypertensive rats was in the same range as in the normotensive animals. These results suggest that the increased peripheral resistance in hypertension is neurogenically mediated and that the increased resistance is due to an increased response of the resistance vessels to normal neurogenic stimulation.
Macrocytic Anaemia of Pregnancy and the Puerperium
Authors: H. W. Fullerton
Journal: BMJ (1943)

rheumatism of childhood cannot be of great importance, since there are many facts that declare it primarily an environmental disorder.Glover (1930) has called rheumatism an obsolescent disease, and this no doubt depends on the slow removal of the appropriate environmental stresses amongst the poor.Such " gradual- ness may be inevitable," but it is suggested that the health of the rheumatic child is improved and stabilized by treatment of its nervous instability.This is done by the removal of the grosser environmental stresses, if possible, by the adjustment of the child's reaction to its environment, and, most important of all, by continuous sedation with phenobarbitone.I am grateful to Lieut.-Col.
Effect of Bronchodilator Aerosol on Ventilatory Capacity in Chronic Lung and Heart Diseases
Authors: B. Gandevia, N. Rogers
Journal: BMJ (1963)

During a review of the results of pulmonary function tests carried out in a diagnostic laboratory note was made of the effect on ventilatory capacity of a bronchodilator aerosol in three groups of patients: those with obstructive lung disease, those with diffuse interstitial pulmonary fibrosis, and those with mitral and aortic valve disease.The findings are here briefly recorded as they are of some therapeutic significance and interest.
Pretargeting CD45 enhances the selective delivery of radiation to hematolymphoid tissues in nonhuman primates
Authors: Damian J. Green, John M. Pagel, Eneida R. Nemecek, Yukang Lin, Aimee Kenoyer, Anastasia Pantelias, Donald K. Hamlin, D. Scott Wilbur, Darrell R. Fisher, Joseph G. Rajendran, Ajay K. Gopal, Steven I. Park, Oliver W. Press
Journal: Blood (2009)
Pigmented nail bands and mucocutaneous pigmentation in HIV-positive patients treated with zidovudine
Authors: M. Grau-Massanes, F. Millan, M.I. Febrer, C. Pujol, V.A. Alegre, M. Salavert, V. Navarro, A. Aliaga
Journal: Journal of the American Academy of Dermatology (1990)
Abstract 1080: Effect of IGF2 overexpression on the tumorigenicity of human ovarian carcinoma cells
Authors: Jurriaan Brouwer-Visser, María J. Cossio, Suzan K. Chao, Gloria S. Huang
Journal: Cancer Research (2012)

Abstract Introduction High Insulin-like Growth Factor 2 (IGF2) tumor expression correlates with reduced disease-free survival in epithelial ovarian tumors. IGF2 mRNA is also upregulated after Taxol treatment of ovarian cancer cells. The purpose of this study was to determine the effect of IGF2 overexpression on the tumorigenicity of human ovarian cancer cells. Methods HEY cells were stably transfected using lentiviral particles with IGF2 or no insert (EV) constructs. qPCR and ELISA were performed to measure the IGF2 mRNA and secreted protein expression levels, respectively. Signaling pathways were probed by immunoblotting. Tumorigenicity was evaluated in athymic nude mice by subcutaneous injection of serial cell dilutions with matrigel, followed by monitoring of in vivo tumor growth by caliper measurements. qPCR for IGF2 mRNA and immunohistochemistry for Ki67 were performed on the excised tumors. Results The IGF2 mRNA level was 4679 ±176 fold-change higher in HEY-IGF2 cells relative to HEY-EV cells (P&amp;lt;0.0001). The amount of IGF2 protein secreted in 48 h was 5159 ng/100,000 HEY-IGF2 cells (51.6 pg/cell), and undetectable in the media of HEY-EV cells. Tyrosine phosphorylation of the IGF1-receptor was increased 13-fold in HEY-IGF2 cells. In vitro, dependency on the IGF1-receptor signaling was unaltered, as IGF2 overexpressing cells responded similarly to the IGF1-receptor inhibitor NVP-AEW541 compared to HEY-EV cells. Following an injection of one million cells with matrigel, the mean tumor volume of xenografts after 4 weeks was 1608 ±330 mm3 versus 705 ±95 mm3 for HEY-IGF2 and HEY-EV xenografts, respectively (P=0.04, N=6 per group). Immunohistochemistry for Ki67 showed a significantly higher percentage of stained nuclei in HEY-IGF2 tumors than in HEY-EV tumors (P=0.04, N=3 per group). Discussion Stable overexpression of IGF2 in HEY ovarian cancer cells resulted in an increased xenograft growth rate. Further evaluation is underway to fully characterize the mechanisms by which IGF2 overexpression promotes tumor growth. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1080. doi:1538-7445.AM2012-1080
Information needs of cancer patients in west Scotland: cross sectional survey of patients' views
Authors: C. Meredith, P. Symonds, L. Webster, D. Lamont, E. Pyper, C. R Gillis, L. Fallowfield
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To assess the needs of patients with cancer for information about their condition. <b>Design</b>: Cross sectional survey of patients9 views by means of semistructured interview with questionnaire. <b>Setting</b>: A regional cancer centre and two university hospitals in west Scotland. <b>Subjects</b>: 250 (93%) of 269 cancer patients invited to participate in study who were selected by age, sex, socioeconomic status, and tumour site to be representative of cancer patients in west Scotland. <b>Main outcome measures</b>: Patients9 need to know whether they had cancer, the medical name of their illness, progress through treatment, how treatment works, side effects, chances of cure, and treatment options. <b>Results</b>: 79% (95% confidence interval 73% to 84%) of patients wanted as much information as possible, and 96% (93% to 98%) had a need or an absolute need to know if they had cancer. Most patients also wanted to know the chance of cure (91% (87% to 94%)) and about side effects of treatment (94% (90% to 97%)). When the replies were cross tabulated with patients9 age, sex, deprivation score, and type of treatment there was a linear trend for patients from more affluent areas to want more information and those from deprived areas to want less. There was a strong preference for diagnosis of cancer to be given by a hospital doctor (60% (53% to 66%). <b>Conclusion</b>: Almost all patients wanted to know their diagnosis, and most wanted to know about prognosis, treatment options, and side effects. <h3>Key messages</h3> We interviewed 250 patients with cancer to find out what information they wanted Almost all the patients wanted to know their diagnosis, and most also wanted to know the chance of cure and the side effects of their treatment Younger patients, women, and those receiving radical treatment in particular wanted to know more about treatment options The overwhelming preference was for the diagnosis of cancer to be given by a hospital doctor
An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer
Authors: Michael A. Morse, Amy C. Hobeika, Takuya Osada, Peter Berglund, Bolyn Hubby, Sarah Negri, Donna Niedzwiecki, Gayathri R. Devi, Bruce K. Burnett, Timothy M. Clay, Jonathan Smith, H. Kim Lyerly
Journal: Journal of Clinical Investigation (2010)

Therapeutic anticancer vaccines are designed to boost patients' immune responses to tumors. One approach is to use a viral vector to deliver antigen to in situ DCs, which then activate tumor-specific T cell and antibody responses. However, vector-specific neutralizing antibodies and suppressive cell populations such as Tregs remain great challenges to the efficacy of this approach. We report here that an alphavirus vector, packaged in virus-like replicon particles (VRP) and capable of efficiently infecting DCs, could be repeatedly administered to patients with metastatic cancer expressing the tumor antigen carcinoembryonic antigen (CEA) and that it overcame high titers of neutralizing antibodies and elevated Treg levels to induce clinically relevant CEA-specific T cell and antibody responses. The CEA-specific antibodies mediated antibody-dependent cellular cytotoxicity against tumor cells from human colorectal cancer metastases. In addition, patients with CEA-specific T cell responses exhibited longer overall survival. These data suggest that VRP-based vectors can overcome the presence of neutralizing antibodies to break tolerance to self antigen and may be clinically useful for immunotherapy in the setting of tumor-induced immunosuppression.
Hypertension Control in African-American Patients with Chronic Kidney Disease
Authors: Julie R. Ingelfinger
Journal: New England Journal of Medicine (2010)

The risks of renal and cardiovascular disease — conditions that are often associated with long-standing hypertension — are far higher among people of African-American heritage than among those in other racial or ethnic groups. The African-American Study of Kidney Disease and Hypertension (AASK)1 is an important long-term study that compared standard with intensive therapy for hypertension among 1094 black patients with chronic kidney disease, defined as a glomerular filtration rate (GFR) of 20 to 65 ml per minute per 1.73 m2 of body-surface area. The study was conducted in a trial phase, followed by an observational cohort phase. The primary . . .
Teens and Gun Trafficking
Authors: Nancy A. Dodson, David Hemenway
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal