tbuckley/cabot-search huggingface dataset:
P255Galectin-3: a new promising cardiac biomarker in sports endurance?
Authors: C Le Goff, S Devaux, E Brevers, S Peeters, JF Kaux, E Cavalier
Journal: Cardiovascular Research (2014)

Purpose: Galectin-3 (Gal-3) is well-known as a very interesting biomarker for heart failure and myocardial fibrosis. Gal-3 is a carbohydrate binding lectin produced by macrophages, upregulated in hypertrophied heart, emerging as an important mediator for fibrosis development and cardiac remodeling. We aimed to examine the evolution of Gal-3 in some endurances runners compared to sedentary subjects and the correlation of its evolution with other cardiac and renal biomarkers. Methods: Twenty-eight males (mean age 37 ± 8.5 yo), 9 healthy non-elite marathon runners (42 km), 10 ultratour runners (67 km) and 9 sedentary subjects (10 km, <2h of sport/week). Blood samples were taken just before (T0), just after (T1) and 3 hours (T3) after the race. The biomarkers used for the correlation were: highly sensitive troponin T (TnThs), N-terminal-pro brain natriuretic peptide (NT-proBNP), myoglobin (MYO), myeloperoxydase (MPO), cystatine C (CYSC), creatinin (Cr). The analyses were performed on the VIDAS (Biomerieux) and COBAS (Roche Diagnostics) according to the manufacturer's specifications. The study was approved by the Ethical Committee of our University Hospital. Results: The concentration of all biomarkers measured in the post-race (T1 and T3) samples was remarkably increased, compared with the values obtained on baseline (T0) specimens. Plasma Gal-3 increased from baseline to post exercise and decreased in the 3 hours after the end of the exercise. Indeed, at T1, we observed that the level is higher in marathon runner (mean at T1 = 25 ± 5.08 ng/ml) than in ultratour (mean at T1 = 18.7 ± 4.45ng/ml) and in the sedentary runners (mean at T1 = 11.88 ± 2.09 ng/ml). The concentrations obtained for the marathon runners at T1 could be considered as a risk predictor of cardiovascular event in the general population. Interestingly, baseline plasma levels of Gal-3 were in normal range but higher than in healthy sedentary controls. There is a correlation between the increase of Gal-3 and TnThs, NT-proBNP, MYO, MPO, CYSC, Cr. Conclusions: The results of this study demonstrate that exercises of different intensity are associated with biochemical abnormalities that may reflect adverse consequences on cardiac structure as fibrosis and biology.
Myxoma Virus Oncolysis of Primary and Metastatic B16F10 Mouse Tumors In Vivo
Authors: Marianne M Stanford, Mae Shaban, John W Barrett, Steven J Werden, Philippe-Alexandre Gilbert, Joe Bondy-Denomy, Lisa MacKenzie, Kevin C Graham, Ann F Chambers, Grant McFadden
Journal: Molecular Therapy (2007)

Myxoma virus (MV) is a rabbit-specific poxvirus, whose unexpected tropism to human cancer cells has led to studies exploring its potential use in oncolytic therapy. MV infects a wide range of human cancer cells in vitro, in a manner intricately linked to the cellular activation of Akt kinase. MV has also been successfully used for treating human glioma xenografts in immunodeficient mice. This study examines the effectiveness of MV in treating primary and metastatic mouse tumors in immunocompetent C57BL6 mice. We have found that several mouse tumor cell lines, including B16 melanomas, are permissive to MV infection. B16F10 cells were used for assessing MV replication and efficacy in syngeneic primary tumor and metastatic models in vivo. Multiple intratumoral injections of MV resulted in dramatic inhibition of tumor growth. Systemic administration of MV in a lung metastasis model with B16F10LacZ cells was dramatically effective in reducing lung tumor burden. Combination therapy of MV with rapamycin reduced both size and number of lung metastases, and also reduced the induced antiviral neutralizing antibody titres, but did not affect tumor tropism. These results show MV to be a promising virotherapeutic agent in immunocompetent animal tumor models, with good efficacy in combination with rapamycin. Myxoma virus (MV) is a rabbit-specific poxvirus, whose unexpected tropism to human cancer cells has led to studies exploring its potential use in oncolytic therapy. MV infects a wide range of human cancer cells in vitro, in a manner intricately linked to the cellular activation of Akt kinase. MV has also been successfully used for treating human glioma xenografts in immunodeficient mice. This study examines the effectiveness of MV in treating primary and metastatic mouse tumors in immunocompetent C57BL6 mice. We have found that several mouse tumor cell lines, including B16 melanomas, are permissive to MV infection. B16F10 cells were used for assessing MV replication and efficacy in syngeneic primary tumor and metastatic models in vivo. Multiple intratumoral injections of MV resulted in dramatic inhibition of tumor growth. Systemic administration of MV in a lung metastasis model with B16F10LacZ cells was dramatically effective in reducing lung tumor burden. Combination therapy of MV with rapamycin reduced both size and number of lung metastases, and also reduced the induced antiviral neutralizing antibody titres, but did not affect tumor tropism. These results show MV to be a promising virotherapeutic agent in immunocompetent animal tumor models, with good efficacy in combination with rapamycin.
Acquired pure red cell aplasia associated with malignant lymphomas: A nationwide cohort study in Japan for the PRCA Collaborative Study Group
Authors: Makoto Hirokawa, Ken‐ichi Sawada, Naohito Fujishima, Fumio Kawano, Akiro Kimura, Takashi Watanabe, Ayako Arai, Toshimitsu Matsui, Shinji Nakao, Akio Urabe, Mitsuhiro Omine, Keiya Ozawa
Journal: American Journal of Hematology (2008)

Pure red cell aplasia (PRCA) has been reported in association with lymphoma as one of the autoimmune diseases seen during the course of lymphoid malignancies. However, the relation of PRCA with the underlying lymphomas remains unclear. The aim of this study was to clarify the histologic subtypes of lymphomas, the chronological sequence of anemia and lymphoma, and the response to treatment. We conducted a nationwide survey in Japan. From a cohort of 185 PRCA patients, 8 patients with lymphoma were evaluated. Histologic subtypes varied and the lymphoma was of the B-cell type in four cases and of the T-cell type in four. Four patients simultaneously developed PRCA and lymphoma. Three patients developed PRCA following lymphoma, two of whom developed anemia during remission of lymphoma. PRCA preceded lymphoma in one patient. Effective chemotherapy was associated with remission of anemia in concurrent lymphoma and PRCA. Overall, anemia responded to chemotherapy and/or immunosuppressive therapy in seven patients. In four responding patients, PRCA remained in durable remission without maintenance immunosuppressive therapy, which is different from a recurrent feature of idiopathic PRCA. We suggest that the mechanism of lymphoma-associated PRCA is heterogeneous and that durable maintenance-free remission of anemia can be obtained in some patients.
In Praise of the Hyperglycemic Clamp: A method for assessment of β-cell sensitivity and insulin resistance
Authors: Dariush Elahi
Journal: Diabetes Care (1996)

The most widely used methods for the assessment of beta-cell response and peripheral tissue sensitivity to insulin include the oral glucose tolerance test (OGTT), the frequently sampled intravenous glucose tolerance test, and the hyperinsulinemiceuglycemic clamp technique. During an OGTT, glucose levels increase after a variable lag period, then reach a peak and fall variably among individuals. The response even varies in the same subject upon repeat testing. A more reproducible glucose curve is achieved with an intravenous glucose tolerance test in which the plasma glucose levels rise rapidly to a very high level and fall exponentially. In neither of the two methods is a steady-state glucose level achieved. In the hyperinsulinemic-euglycemic clamp technique, a steady-state glucose level can be maintained at any level of hyperinsulinemia. However, an assessment of beta-cell sensitivity is not obtained. The less used hyperglycemic clamp technique can assess beta-cell sensitivity as well as peripheral tissue sensitivity. Moreover, a measure of glucose effectiveness or non-insulin-mediated glucose uptake can also be determined. With this technique the beta-cells of all subjects are stimulated with the same arterial glucose concentration, thus enabling assessment of beta-cell response to identical plasma glucose levels. Comparison of responses to stable hyperglycemic stimuli can be made in glucose-tolerant and -intolerant states with the addition of various substances, either alone or in combination. The use of the hyperglycemic clamp and several of its variant forms is reviewed as an alternative method for assessment of glucose homeostasis.
THE UNEXPLORED FIELD OF PREVENTIVE MEDICINE IN PRIVATE PRACTICE
Authors: W. F. DRAPER
Journal: JAMA (1927)

The U. S. Public Health Service is a medical organization. Its commissioned corps is composed entirely of doctors of medicine recruited from the ranks of the general profession. Its paramount duty may he said to be the conservation and improvement of the health of the inhabitants of this country, to the extent that the powers and facilities conferred and afforded by Congress make this possible. In performing this duty this service makes use of medical knowledge, the heritage of the centuries of patient and careful observation and experiment which our professional forebears have handed down to us and which we are all endeavoring to perfect and expand. I have made these statements to emphasize the fact that in appearing before this section as a representative of the Public Health Service I come as a medical man representing a medical body—one which shares the traditions, the training, the aspirations and, it
Socioeconomical conditions as risk factors for bronchial asthma in children aged 4–5 yrs
Authors: M. Lindbæk, K.W. Wefring, E.H. Grangård, K. Øvsthus
Journal: European Respiratory Journal (2002)

A number of factors are associated with the development of childhood asthma. The purpose of this study was to establish the prevalence of childhood asthma and to explore the socioeconomic background factors associated with childhood asthma in a Norwegian cohort of children aged 4–5 yrs. A questionnaire was given to parents in connection with the ordinary child control of 4–5‐yr-old children in Vestfold county, Norway. In addition to the question “Has the child at present or ever had asthma?”, a number of medical and socioeconomical background factors were registered. Of the 2,430 parents, 1,913 (79%) responded. Of the 163 (cumulative prevalence 8.7%) children with confirmed asthma, 19 did not use any medication and were regarded as having outgrown their asthma. Several background factors were significantly associated with asthma in a logistic regression analysis: few rooms at home, psychosocial problems, fever more than three times during the last year, hay fever, reaction to food and mother or father with chronic disease. The findings indicate that socioeconomic background factors are associated with asthma in childhood, in addition to other known risk factors.
PERSONALITY STUDIES IN MENOPAUSAL WOMEN
Authors: KARL STERN, MIGUEL PRADOS
Journal: American Journal of Psychiatry (1946)

Fifty patients who attended a medical or gynæcological outdoor department with the diagnosis of "menopausal syndrome" were examined psychiatrically with interviews, social histories and, in all but 5 cases, Rorschach tests. In 23 cases the emotional disturbances were the chief spontaneous complaint so that a psychiatrist had been called in as consultant. The remaining 27 cases would not have been seen by a psychiatrist, had it not been for this study. "Menopausal depression" is a uniform clinical picture ; it is a reactive depression which presents only an accentuation of a previously existing maladjustment. It is clearly distinguishable from other so-called involutional disorders. The "causes" of this depression in the group examined are most frequently crude and obvious. They are almost exclusively associated with marriage and reproduction. The patient's premorbid personality differs essentially from that described by previous authors as characteristic of involutional psychoses. There is no correlation between the intensity of hot flushes on one hand and the severity of the emotional disturbance on the other. There does not appear to be any correlation between estrogenic deficiency and the severity of the emotional disturbance. Among complaints, pelvic pain is most intimately associated with the more severe forms of maladjustment. Considerably more of the cases of artificial menopause were found among the severely maladjusted women. In the majority of these cases, however, the injurious life situation preceded the artificial menopause. A qualitative descriptive study of these cases suggests that the patients reacted to psychological traumas with uterine dysfunction. From this it appears that the "menopausal" character of these depressive reactions is due to an additional conversion mechanism. An attempt is being made to explain this mechanism on the basis of our case studies.
CD10 is expressed in dermatofibromas
Authors: K-J. Lee, J-M. Yang, E-S. Lee, D-Y. Lee, K-T. Jang
Journal: British Journal of Dermatology (2006)

Journal Article CD10 is expressed in dermatofibromas Get access K‐J. Lee, K‐J. Lee Departments of Dermatology and Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon‐Dong, Gangnam‐Gu, Seoul 135–710, Korea Dong‐Youn Lee. E‐mail: dylee@smc.samsung.co.kr Search for other works by this author on: Oxford Academic Google Scholar J‐M. Yang, J‐M. Yang Departments of Dermatology and Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon‐Dong, Gangnam‐Gu, Seoul 135–710, Korea Search for other works by this author on: Oxford Academic Google Scholar E‐S. Lee, E‐S. Lee Departments of Dermatology and Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon‐Dong, Gangnam‐Gu, Seoul 135–710, Korea Search for other works by this author on: Oxford Academic Google Scholar D‐Y. Lee, D‐Y. Lee Departments of Dermatology and Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon‐Dong, Gangnam‐Gu, Seoul 135–710, Korea Search for other works by this author on: Oxford Academic Google Scholar K‐T. Jang K‐T. Jang Departments of Dermatology and Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon‐Dong, Gangnam‐Gu, Seoul 135–710, Korea Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 3, 1 September 2006, Pages 632–633, https://doi.org/10.1111/j.1365-2133.2006.07375.x Published: 01 September 2006
Abstract 5282: The role of T3-regulated microRNAs in human hepatoma cells.
Authors: Ya-Hui Huang, Yang-Hsiang Lin, Ching-Ying Chen, Kwang-Huei Lin
Journal: Cancer Research (2013)

Abstract Thyroid hormone (T3)/thyroid hormone receptor (TR) signaling regulates cellular growth, development and differentiation, which play important roles in vivo. T3/TR signaling promotes invasion while suppressing proliferation of hepatoma cells. MicroRNAs (miRNA) are small, short, endogenously expressed non-coding RNAs that negatively regulate gene expression. Aberrant miRNA expression has been observed in various tumor types, including hepatocellular carcinoma. At present, it is unclear whether T3/TR signaling regulates miRNAs in hepatoma cells. In our laboratory, miRNA profiling analysis using the high-throughput stem-loop RT-qPCR method revealed upregulation of miR-21 by T3/TR. A native thyroid hormone response element was identified in the primary miR-21 promoter region using promoter and chromatin immunoprecipitation assays. Overexpression of miR-21 promoted hepatoma cell migration and invasion, similar to that observed with T3 stimulation in hepatoma cells. In addition, anti-miR-21-induced suppression of cell migration was rescued by T3. T-cell lymphoma invasion and metastasis 1 (Tiam1), involved in cell migration and invasion, was identified as a miR-21 target, and downregulated by T3. Tiam1 was upregulated upon knockdown of miR-21, and conversely, downregulated upon miR-21 overexpression. Further, knockdown of Tiam1 enhanced migration and invasion may through increase of vimentin and MMP2 expression in hepatoma cells. The correlation among T3/TR, miR-21 and Tiam1 was observed in vivo is similar with in vitro. These findings indicate that miR-21 is directly upregulated by T3. Moreover, T3-mediated enhancement of hepatoma cell migration and invasion may through miR-21-targeted downregulation of Tiam1. Citation Format: Ya-Hui Huang, Yang-Hsiang Lin, Ching-Ying Chen, Kwang-Huei Lin. The role of T3-regulated microRNAs in human hepatoma cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5282. doi:10.1158/1538-7445.AM2013-5282
A Comparison of Hepatic Mucinous Cystic Neoplasms With Biliary Intraductal Papillary Neoplasms
Authors: Tao Li, Yuan Ji, Xu–Ting Zhi, Lu Wang, Xin–Rong Yang, Guo–Ming Shi, Wei Zhang, Zhao–You Tang
Journal: Clinical Gastroenterology and Hepatology (2009)
Regeneration of Infarcted Myocardium by Intramyocardial Implantation of Ex Vivo Transforming Growth Factor-β–Preprogrammed Bone Marrow Stem Cells
Authors: Tao-Sheng Li, Masanori Hayashi, Hiroshi Ito, Akira Furutani, Tomoaki Murata, Masunori Matsuzaki, Kimikazu Hamano
Journal: Circulation (2005)

Recent studies have shown that bone marrow-derived stem cells differentiate into the phenotype of cardiomyocytes in vivo and in vitro. We tried to regenerate infarcted myocardium by implanting ex vivo transforming growth factor (TGF)-beta-preprogrammed CD117 (c-kit)-positive (CD117+) stem cells intramyocardially.CD117+ cells were isolated from the bone marrow mononuclear cells of GFP-transgenic or normal C57/BL6 mice. The myogenic differentiation of CD117+ cells was achieved by cultivation with TGF-beta. Using an acute myocardial infarction model, we also tried to regenerate infarcted myocardium by implanting untreated (newly isolated) or preprogrammed (24 hours of cultivation with 5 ng/mL TGF-beta1) CD117+ cells intramyocardially. TGF-beta increased the cellular expression of myosin, troponins, connexin-43, GATA-4, and NKx-2.5, which suggested that it induced the myogenic differentiation of CD117+ cells. Compared with the effects of PBS injection only, the microvessel density in the infarcted myocardium was increased significantly 3 months after the implantation of either TGF-beta-preprogrammed or untreated CD117+ cells. Moreover, many of the TGF-beta-preprogrammed CD117+ cells were stained positively for myosin, whereas few of the untreated CD117+ cells were. Histological analysis revealed newly regenerated myocardium in the left ventricular anterior wall after the implantation of TGF-beta-preprogrammed cells but not untreated cells. Furthermore, the left ventricular percent fraction shortening was significantly higher after the implantation of TGF-beta-preprogrammed cells than after the implantation of untreated CD117+ cells.TGF-beta conducted the myogenic differentiation of CD117+ stem cells by upregulating GATA-4 and NKx-2.5 expression. Therefore, the intramyocardial implantation of TGF-beta-preprogrammed CD117+ cells effectively assisted the myocardial regeneration and induced therapeutic angiogenesis, contributing to functional cardiac regeneration.
On Encountering Hopelessness
Authors: Lisa Shulman
Journal: JAMA (1977)

SOMETIMES we encounter a situation for which we have not been prepared, which confounds us and calls our assumptions into question. Certain patients force such a crisis on us, allowing us in our resolution of it to again come to terms with our commitment. Paradoxically, the situation is not always generated by the seriousness or arcane nature of the patient's disease. Sometimes, in fact, the diseases are much like many others we have seen, unique in their particulars, but so familiar in their clinical presentation that we type them, treat them, and look for no more in them than an expected sequence of laboratory values and clinical findings, unless something stirs us to look deeper, and learn. <h3>Report of a Case</h3> A 78-year-old former baseball player and insurance salesman was brought to the emergency room by his wife, disoriented and unmanageable. His history showed that he had been forgetful and
Lower-zone emphysema in young patients without 1-antitrypsin deficiency
Authors: N. A. Martelli, E. Goldman, A. J. Roncoroni
Journal: Thorax (1974)

<b>Martelli, N. A., Goldman, E., and Roncoroni, A. J. (1974).</b><i>Thorax</i>, <b>29</b>, 237-244. <b>Lowerzone emphysema in young patients without</b> α<sub>1</sub><b>-antitrypsin deficiency.</b> Three young patients with radiographic pulmonary emphysema predominantly in the lower zones are reported. The clinical and physiological features were those observed in severe pulmonary emphysema. Predominance of the main lesions in the lower zones was confirmed in two cases by selective pulmonary angiography. One of the patients died and extensive panlobular emphysema was found at necropsy. Although the similarities between our patients and those with emphysema and α<sub>1</sub>-antitrypsin deficiency were remarkable, the latter condition was ruled out.
Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation.
Authors: D F Dinges, S D Douglas, L Zaugg, D E Campbell, J M McMann, W G Whitehouse, E C Orne, S C Kapoor, E Icaza, M T Orne
Journal: Journal of Clinical Investigation (1994)

The hypothesis that sleep deprivation depresses immune function was tested in 20 adults, selected on the basis of their normal blood chemistry, monitored in a laboratory for 7 d, and kept awake for 64 h. At 2200 h each day measurements were taken of total leukocytes (WBC), monocytes, granulocytes, lymphocytes, eosinophils, erythrocytes (RBC), B and T lymphocyte subsets, activated T cells, and natural killer (NK) subpopulations (CD56/CD8 dual-positive cells, CD16-positive cells, CD57-positive cells). Functional tests included NK cytotoxicity, lymphocyte stimulation with mitogens, and DNA analysis of cell cycle. Sleep loss was associated with leukocytosis and increased NK cell activity. At the maximum sleep deprivation, increases were observed in counts of WBC, granulocytes, monocytes, NK activity, and the proportion of lymphocytes in the S phase of the cell cycle. Changes in monocyte counts correlated with changes in other immune parameters. Counts of CD4, CD16, CD56, and CD57 lymphocytes declined after one night without sleep, whereas CD56 and CD57 counts increased after two nights. No changes were observed in other lymphocyte counts, in proliferative responses to mitogens, or in plasma levels of cortisol or adrenocorticotropin hormone. The physiologic leukocytosis and NK activity increases during deprivation were eliminated by recovery sleep in a manner parallel to neurobehavioral function, suggesting that the immune alterations may be associated with biological pressure for sleep.
Influenza vaccine is delayed by problems in growing virus strain
Authors: Andrew Cole
Journal: BMJ (2006)

against the use of docetaxel.At the time the appraisal committee found that there was "too much uncertainty about the evidence to make a clear judgment on its clinical and cost effectiveness compared with current practice in England and Wales" (bmj.com, 6 May 2006, News Extra).NICE asked for more information on the clinical and cost effectiveness of docetaxel in combination with doxorubicin and cyclophosphamide when compared with currently used regimens, including a combination of 5-fluorouracil, cyclophosphamide, and epirubicin.The committee concluded that the evidence supported that the docetaxel regimen was clinically and cost effective in comparison with standard practice.