Atorvastatin-Induced Polyneuropathy
Authors: Chad Silverberg
Journal: Annals of Internal Medicine (2003)

Letters4 November 2003Atorvastatin-Induced PolyneuropathyChad Silverberg, BA, BSChad Silverberg, BA, BSFrom Ellicott City, MD 21042.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-9-200311040-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Statins are the most effective agents for reducing serum cholesterol and low-density lipoprotein levels, and they improve morbidity and mortality associated with chronic hyperlipidemia (1). Studies of these drugs have identified side effects, including myopathy and hepatotoxicity; however, recent reports have also implicated statins in polyneuropathy (2, 3). The significance of statin use in modern medicine continues to grow. Recently, statins have shown promise in the treatment of multiple sclerosis and are being evaluated for use after myocardial infarction (4, 5). With increased use of statins and advancement in the spectrum of their utility, more cases ...References1. Hardman JG, Limbird LE, eds. 10th ed Goodman & Gilman's The Pharmacological Basis of Therapeutics. New York: McGraw-Hill; 2001:883. Google Scholar2. Bernini F, Poli A, Paoletti R. Safety of HMG-CoA reductase inhibitors: focus on atorvastatin. Cardiovasc Drugs Ther. 2001;15:211-8. [PMID: 11713888] CrossrefMedlineGoogle Scholar3. Gaist D, Jeppesen U, Andersen M, Garcia Rodriguez LA, Hallas J, Sindrup SH. Statins and risk of polyneuropathy: a case–control study. Neurology. 2002;58:1333-7. [PMID: 12011277] CrossrefMedlineGoogle Scholar4. Nahrendorf M, Hu K, Hiller KH, Galuppo P, Fraccarollo D, Schweizer G, . Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: an experimental serial cardiac magnetic resonance imaging study. J Am Coll Cardiol. 2002;40:1695-700. [PMID: 12427425] CrossrefMedlineGoogle Scholar5. Neuhaus O, Strasser-Fuchs S, Fazekas F, Kieseier BC, Niederwieser G, Hartung HP, . Statins as immunomodulators: comparison with interferon- 1b in MS. Neurology. 2002;59:990-7. [PMID: 12370451] CrossrefMedlineGoogle Scholar6. Richardson JD, Vasko MR. Cellular mechanisms of neurogenic inflammation. J Pharmacol Exp Ther. 2002;302:839-45. [PMID: 12183638] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Chad Silverberg, BA, BSAffiliations: From Ellicott City, MD 21042. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAtorvastatin-Induced Polyneuropathy Michael B. Jacobs Metrics Cited byClinicians' Reports in Electronic Health Records Versus Patients' Concerns in Social Media: A Pilot Study of Adverse Drug Reactions of Aspirin and AtorvastatinAtorvastatinLIPID – REGULATING DRUGSTREATMENT WITH STATINS AND INVOLVEMENT OF THE PERIPHERAL NERVOUS SYSTEM: RESULTS OF A PROSPECTIVE CLINICAL AND NEUROPHYSIOLOGICAL FOLLOW-UPDixièmes Journées des Maladies du Système Nerveux Périphérique Neuropathies aux statines, mythe ou réalité?Genetic risk factors associated with lipid-lowering drug-induced myopathiesStatins and polyneuropathy: Setting the record straightToxic neuropathyAdverse effects of statinsDrugs that affect lipid metabolismPeripheral neuropathyStatin-Associated Peripheral Neuropathy: Review of the LiteratureAtorvastatin-Induced PolyneuropathyMichael B. Jacobs, MDCurrent awareness: Pharmacoepidemiology and drug safetyAcute Delirium after Hepatitis a Vaccine Ocular Side Effects with Topiramate Omeprazole-Induced Intractable Cough Levetiracetam Behavioral Side Effects: Another Large Review Atorvastatin-Induced Polyneuropathy Prolonged Thrombocytopenia in a Patient Using Isotretinoin 4 November 2003Volume 139, Issue 9Page: 792-793KeywordsBiopsyComplete blood countCreatinine phosphokinaseDrugsHyperlipidemiaNeuronsNeuropathyStatinsTicksWalking ePublished: 4 November 2003 Issue Published: 4 November 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...