tbuckley/cabot-search huggingface dataset:
Abstract 1579: TGF-β blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma model
Authors: Shan Liao, JieQiong Liu, Rakesh K. Jain, Lei Xu
Journal: Cancer Research (2011)

Abstract Ovarian cancer is characterized by the rapid growth of solid intraperitoneal tumors and accumulation of ascites, the ascites being the clinical presentation of end-stage disease. The role of Transforming Growth Factor beta (TGF-β) in tumor progression has been well studied. However, the role of TGF-β in lymphatic vessel function remains far from understood. We study the effect and mechanisms of TGF-β blockade in human ovarian cancer. We report that blocking tumor and host TGF-β signaling can significantly inhibit the growth of both VEGF- and IL-8-dependent human ovarian tumors. More importantly, we have shown that TGF-β blockade significantly decreases the volume of ascites by both inhibiting ascites formation and preventing impairment of lymphatic vessel drainage, thus demonstrating its potential as a promising new treatment for malignant ascites. Since a number of agents that target the TGF-β-pathway are in clinical trials, the results of the proposed study could be rapidly translated to the clinic. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1579. doi:10.1158/1538-7445.AM2011-1579
Sensory Neuropathy from Pyridoxine Abuse
Authors: Herbert Schaumburg, Jerry Kaplan, Anthony Windebank, Nicholas Vick, Stephen Rasmus, David Pleasure, Mark J. Brown
Journal: New England Journal of Medicine (1983)

We describe seven adults who had ataxia and severe sensory-nervous-system dysfunction after daily high-level pyridoxine (vitamin B6) consumption. Four were severely disabled; all improved after withdrawal. Weakness was not a feature of this condition, and the central nervous system was clinically spared. Although consumption of large doses of pyridoxine has gained wide public acceptance, this report indicates that it can cause sensory neuropathy or neuronopathy syndromes and that safe guidelines should be established for the use of this widely abused vitamin. (N Engl J Med 1983; 309:445–8.)
Influence of HIV Infection on Manifestations and Natural History of Other Sexually Transmitted Diseases
Authors: A Wald, L Corey, H H Handsfield, K K Holmes
Journal: Annual Review of Public Health (1993)

In recent decades, public health policy and practice have been increasingly challenged by globalization, even as global financing for health has increased dramatically. This article discusses globalization and its health challenges from a vantage of ...Read More
The Point of View of Organized Medicine toward the Distribution of Medical Care
Authors: Louis H. Bauer
Journal: New England Journal of Medicine (1946)

THE problem to be discussed is that of medical care. It is a controversial issue; in fact, if it were not so there would be no problem. I should like to appeal for a sound and sane method of approaching it. It is a problem that is comparatively recent, having developed within the last two decades. It has been brought about by the increased costs of medical care.One of the reasons for this situation has been the increased cost of medical education, but the chief one has been the increased cost in diagnosis. After all, the physician giving the . . .
“Constraint” versus “choice” in preferred movement patterns
Authors: Kenneth G. Holt
Journal: Behavioral and Brain Sciences (1996)

Abstract Movement patterns in impaired gait are not selected by a smart central nervous system (CNS), but arise by virtue of mutual constraints of task, limitations in personal dynamics available for the task, and optimality criteria. An oscillatory model of gait cycle is presented that exemplifies this control and coordination scheme. Preferred gait patterns may be based on physical principles rather than CNS “coordinative rules.”
Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study
Authors: April Zambelli-Weiner, Eva Ehrlich, Maria L. Stockton, Audrey V. Grant, Shu Zhang, Paul N. Levett, Terri H. Beaty, Kathleen C. Barnes
Journal: Journal of Allergy and Clinical Immunology (2005)
Mechanism of skin tumorigenesis by contact sensitizers: the effect of the corticosteroid fluocinolone acetonide on inflammation and tumor induction by 2,4 dinitro-1-fluorobenzene in the skin of the TG.AC (v-Ha-ras) mouse.
Authors: R E Albert, J E French, R Maronpot, J Spalding, R Tennant
Journal: Environmental Health Perspectives (1996)

The effect of the corticosteroid fluocinolone acetonide (FA) on skin tumor induction and inflammation by the contact sensitizer dinitrofluorobenzene (DNFB) was examined. This study broadly relates to the question of whether contact sensitizers, as electrophilic chemicals that produce protein adduction, may constitute an environmental cancer hazard. The specific aim of this study was to evaluate the extent to which the immunogenic inflammatory response to DNFB, in contrast to DNFB cytotoxicity, might be responsible for tumor induction. Experiments were conducted on a transgenic (TG.AC) mouse, incorporating a mutated ras oncogene (v-Ha-ras) that responds rapidly and profusely with skin papillomas to tumor promoters as if it were genetically initiated. Various doses and patterns of DNFB and FA were applied to the skin in a 2-week period; DNFB was given four times and FA was given either with the DNFB or daily. The tumor response to DNFB was completed by 8 weeks from the first dose and was consistent with a dose-squared relationship. FA was not tumorigenic alone; when given with DNFB, it caused only a small reduction in inflammation and tumor yield. When given daily, FA increased ulcerative skin damage, inflammation, and the yield tumors. The results suggest that tumorigenesis by DNFB, in the high-dose short-term regimen used here, is mainly due to its cytotoxicity and not contact sensitization.
Trials of inhaled Iloprost and other new vasodilating prostaglandins
Authors: T. Higenbottam, T. Siddons
Journal: European Respiratory Journal (2001)

Pulmonary hypertension in its many different forms 1 was considered untreatable until the 1990s. With the exception of pulmonary hypertension associated with hypoxic lung disease, where long-term oxygen therapy (LTOT) improves survival in those patients with respiratory failure 2, the various forms of the disease often progress rapidly and lead to premature death. Work carried out in the early 1980s suggested that long-term, continuous intravenous prostacyclin might increase survival in severe primary pulmonary hypertension (PPH) 3, 4. However, these papers reported unrandomized studies. This was also true of a report that showed that long-term anticoagulation improved survival in PPH and chronic thrombo-embolic pulmonary hypertension 5. …
GMC investigates government's director of commissioning development
Authors: C. Dyer
Journal: BMJ (2012)

The UK regulator of doctors, the General Medical Council, is investigating Barbara Hakin, national managing director for commissioning development at the Department of Health for England, over an allegation that in her previous job she prioritised national targets on waiting times at the expense of patient safety.

The investigation relates to Hakin’s time as chief executive of the East Midlands Strategic Health Authority.

Hakin is subject to the GMC’s jurisdiction because she remains on the medical register as a GP, the role she had before moving into management in 2000. The complaint was lodged by the journalists Phil Hammond, who is also a doctor, and Andrew Bousfield, who sent the GMC …
CIRCUMSCRIBED INTRATHORACIC NEOPLASMS
Authors: JOHN ALEXANDER
Journal: JAMA (1942)

There is a prevailing impression among many physicians that most circumscribed intrathoracic neoplasms are extrapulmonary and benign, and that their prompt removal is not important. The basis for this impression is in part the fact that a considerable number of small circumscribed neoplasms at first cause few or no troublesome symptoms and also that such tumors may, for a period of months, remain apparently stationary with regard to growth. The truth is that a majority of circumscribed intrathoracic neoplasms arise within the lung (almost all of them being malignant), many of those that arise outside the lung are malignant and, therefore, the prompt removal of any circumscribed neoplasm which cannot be proved benign is of vital importance. The preoperative demonstration of the exact nature of primary intrathoracic neoplasms is usually impossible unless a specimen of tissue can be obtained for microscopic examination by bronchoscopy, esophagoscopy, needle aspiration or from a
Protecting the Brain in Coronary Artery Bypass Graft Surgery
Authors: Daniel B. Mark
Journal: JAMA (2002)

OR MUCH OF THE 35-YEAR HISTORY OF CORONARY ARtery bypass graft (CABG) surgery, the prevailing belief among cardiovascular physicians was that neurological complications of the procedure were infrequent, consisting primarily of a 1% to 5% incidence of stroke. 1 Some patients reported to their physicians that they were “not quite right” intellectually after the procedure, but such problems were not systematically examined and seemed to be uncommon. Using preoperative and postoperative neuropsychological testing, researchers from many centers have now convincingly demonstrated that measurable cognitive dysfunction is actually a common complication of CABG surgery, with an incidence of up to 80% to 90% at hospital
US Medicaid programme grows to cover 50 million low income people
Authors: B. Roehr
Journal: BMJ (2011)

Medicaid programmes in the US, which provide medical coverage for unemployed people and those on low incomes, climbed to 50.3 million enrollees in June 2010, an increase of 7.2% or 3.37 million people in a single year. 

The bad economy and high unemployment, which nearly doubled from 5% to 9.5%, drove the increase in enrollment by 17.8% or 7.6 million people since the recession began in December 2007, according to the Kaiser Commission on Medicaid and the Uninsured, an operating programme of the charity the Kaiser Family Foundation. The commission regularly compiles and analyses data …
Introduction to the methods used in the generation of the British Thoracic Society guidelines for the management of pleural diseases
Authors: R. J. O. Davies, F. V. Gleeson
Journal: Thorax (2003)

These guidelines have been replaced by BTS Pleural Disease Guideline 2010 Superseded By BTS Pleural Disease Guideline 2010: BTS Guidelines for the Management of Pleural Disease. Thorax 2003 May; 58(Suppl 2): 1–59.
Abstract 2482: <i>Carnitine palmitoyltransferase 1A</i> (<i>CPT1A</i>): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells
Authors: Lingling Liu, Taosheng Chen
Journal: Cancer Research (2012)

Abstract Alveolar rhabdomyosarcoma (ARMS) has a high propensity to metastasize, leading to its aggressiveness and a poor survival rate among those with the disease. More than 80% of aggressive ARMSs harbor a PAX3-FKHR fusion transcription factor, which regulates cell migration and promotes metastasis, most likely by regulating the fusion protein's transcriptional targets. Therefore, identifying druggable transcription targets of PAX3-FKHR that are also downstream effectors of PAX3-FKHR-mediated cell migration and metastasis may lead to novel therapeutic approaches for treating ARMS. To identify genes whose expression is directly affected by the level of PAX3-FKHR in an ARMS cellular-context, we first developed an ARMS cell line in which PAX3-FKHR is stably down-regulated, and showed that stably downregulating PAX3-FKHR in ARMS cells significantly decreased the cells’ motility. We also found that when PAX3-FKHR was downregulated, the expression level of carnitine palmitoyltransferase 1A (CPT1A) decreased. Analysis of the CPT1A promoter identified 4 putative PAX3-FKHR binding sites. Results of mutational analysis, promoter reporter assays, and electrophoretic mobility shift assays showed that PAX3-FKHR binds directly and specifically to a paired-domain binding-site in the CPT1A promoter region, indicating that CPT1A is a novel direct transcriptional target of PAX3-FKHR. Downregulating CPT1A, either by gene knockdown or by using a pharmacologic modulator of CPT1A activity, decreased cell motility in ARMS cells. Taken together, we have identified CPT1A as a novel direct transcriptional target of PAX3-FKHR and revealed the novel function of CPT1A in promoting cell motility. CPT1A may represent a novel therapeutic target for the treatment of ARMS. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2482. doi:1538-7445.AM2012-2482
Long-term (5-Year) Changes in HDL Cholesterol in Cardiac Rehabilitation Patients
Authors: James G. Warner, Peter H. Brubaker, Ying Zhu, Timothy M. Morgan, Paul M. Ribisl, Henry S. Miller, David M. Herrington
Journal: Circulation (1995)

Background It is unknown whether the benefits of a cardiac rehabilitation program on HDL cholesterol (HDL-C) are equally achieved in men and women. To study this, we compared changes in HDL-C and other lipids in a large group of men and women participating in a cardiac rehabilitation program for up to 5 years. Methods and Results We compared changes in HDL-C and other fasting lipids in 553 men and 166 women participating in a cardiac rehabilitation program at baseline and then annually for up to 5 years. Patients exercised 3 days a week at 70% to 85% of their maximum heart rate predetermined by a symptom-limited treadmill test. Aerobic capacity was estimated in metabolic equivalents (METs), and percent body fat was determined by skin-fold measurements. Baseline HDL-C, LDL cholesterol (LDL-C), and total cholesterol were significantly higher in women, whereas the ratio of total cholesterol to HDL-C was lower. Although both men and women showed an increase in HDL-C after 1 year (10% and 7%, respectively), only the women’s level continued to increase over 5 years (20% versus 5% for men, P =.03). The sex difference in change in HDL-C remained after adjustment for age and smoking. A nonsignificant trend toward a greater change in HDL-C in women existed after adjustment for baseline percent body fat and estimated METs. The change in the ratio of total cholesterol to HDL-C was also more favorable in women, with a 38% decrease over 5 years compared with a 14% decrease in men ( P =.01). Total cholesterol decreased by 20% in women and 8% in men ( P =.0001), whereas LDL-C dropped by 34% in women and 15% in men ( P =.0001). There was no sex difference in change in triglycerides. Conclusions Women with heart disease who participate in a cardiac rehabilitation program may achieve greater lipid benefits over longer periods of time than previously demonstrated in men.
Atlas of Gastroenterology
Authors: Phillip M. Berman
Journal: JAMA (1992)

Because gastroenterology is a visual science,<i>Atlas of Gastroenterology</i>, edited by Tadataka Yamada et al, was prepared as a corresponding supplement to the<i>Textbook of Gastroenterology</i>(Philadelphia, Pa, JB Lippincott, 1991) by the same editors. It is designed to correspond to the textbook's chapters and to provide additional visual material such as endophotographs, pictures of gross and microscopic pathology, and diagnostic images of gastrointestinal disorders. More than a picture book, the atlas presents through tables and figures a vast amount of information in an outline format, which can be readily adapted for teaching students, house staff, and others. The brief descriptive copy and line drawings make the photos and images clearly understood. The chapter on endoscopic mucosal biopsy is entirely reproduced from the text. Although I would have preferred the photomicrographs to be in color, there is striking detail in the black-and-white reproductions. This chapter could be published as a
Review: Corticosteroid plus LABA inhalers, vs LABAs alone, reduce morbidity in COPD
Authors: Shawn D. Aaron
Journal: Annals of Internal Medicine (2013)

Source Citation Nannini LJ, Lasserson TJ, Poole P. Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus long-acting beta(2)-agonists for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012;(9):CD006829. 22972099
A Phase 1B Study of Anti-Dll4 (DELTA-LIKE LIGAND 4) Antibody Demcizumab (DEM) with Pemetrexed (PEM) and Carboplatin (CARBO) in Patients with 1St-Line Non-Squamous Nsclc
Authors: J. Dupont, M. McKeage, D. Kotasek, B. Markman, M. Hidalgo, M. Millward, M. Jameson, D. Harris, R. Stagg, B. Hughes
Journal: Annals of Oncology (2015)
Physician Supply and the Health Care Crisis
Authors: Herbert Gershberg
Journal: Annals of Internal Medicine (1990)

Letters15 December 1990Physician Supply and the Health Care CrisisHerbert Gershberg, MDHerbert Gershberg, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-12-996_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:The supply of physicians is increasing at a much greater rate than the general population. In 1960 there were 142 physicians per 100 000 persons in the United States, and this year there are approximately 240 per 100 000 persons. The number of new entrants annually is projected to decrease slowly from 17 500 to 16 200 in 1996 and then remain steady until the year 2010. The number leaving the active population is projected to increase from 7100 to 12 500, resulting in a net increase of from 2900 to 3700 new entrants annually in that...References1. Physician Supply and Utilization by Specialty: Trends and Projections. Chicago: AMA Center for Health and Policy Research; 1988:59. Google Scholar2. Freudenheim M. Job growth in health care soars. New York Times. 5 March 1990:D6. MedlineGoogle Scholar3. SchwartzMendelson WD. No evidence of an emerging physician surplus. An analysis of change in physicians work load and income. JAMA. 1990;263:557-60. CrossrefMedlineGoogle Scholar4. Iglehart J. Health policy report. Canada's health care system faces its problems. N Engl J Med. 1990;322:562-8. CrossrefMedlineGoogle Scholar5. HemenwayKillenCashmanParksBricknell DASCW. Physicians responses to financial incentives. Evidence from a for-profit ambulatory care center. N Engl J Med. 1990;322:1059-63. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 614 Second Avenue New York, NY 10016 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1990Volume 113, Issue 12Page: 996-996KeywordsHealth care ePublished: 1 December 2008 Issue Published: 15 December 1990 PDF downloadLoading ...
Women's Health—Filling the Gaps
Authors: Catherine D. DeAngelis
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Connective tissue components in serum in multiple myeloma: Analyses of propeptides of type I and type III procollagens, type I collagen telopeptide, and hyaluronan
Authors: Niels Abildgaard, Johan Lanng Nielsen, Lene Heickendorff
Journal: American Journal of Hematology (1994)

The present study was performed to evaluate whether information concerning synthesis and degradation of type I collagen in multiple myeloma (MM) as obtained by serum analyses of C-terminal propeptide of type I procollagen (PICP) and the C-terminal telopeptide of type I collagen (ICTP) may be useful in evaluating the development of osteolytic bone destruction. Serum N-terminal propeptide of type III procollagen (PIIINP) may give information about marrow fibrosis in MM. No data are available about MM and serum hyaluronan, another important component of bone marrow stroma. We examined 15 consecutive patients before treatment and 15 sex- and age-matched controls. We found highly significant elevations in serum ICTP (median 6.2 vs. 2.4 micrograms/L; P < 0.01), PIIINP (median 5.2 vs. 2.9 micrograms/L; P < 0.01) and hyaluronan (median 122 vs. 45 micrograms/L; P < 0.01). ICTP in serum correlated closely to bone morbidity (r = 0.69; P < 0.01). Furthermore, serum ICTP correlated highly significantly to serum PIIINP (P < 0.01) and serum beta 2-microglobulin (P < 0.01), whereas there was no correlation between hyaluronan and any of the collagen-derived peptides or beta 2-microglobulin. The MM group was followed for 9-25 months and analysis of survival data suggested that serum ICTP may be of predictive value (P < 0.05). We conclude that important changes in connective tissue metabolism occur in MM. ICTP in serum seems to be a noninvasive marker of bone morbidity and may be of prognostic value. Furthermore, elevation of hyaluronan in serum is common in MM, the significance of which is unknown.