Cimetidine and Impaired Renal Function
Authors: GORDON D. LUK
Journal: Annals of Internal Medicine (1979)

Letters and Correction1 June 1979Cimetidine and Impaired Renal FunctionGORDON D. LUK, M.D., WENDY J. LUK, M.S., THOMAS R. HENDRIX, M.D.GORDON D. LUK, M.D.Search for more papers by this author, WENDY J. LUK, M.S.Search for more papers by this author, THOMAS R. HENDRIX, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-991_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Even though there is now extensive experience with the use of Cimetidine, its use in patients with renal failure is still limited. The manufacturer and others have recommended that the dosage of Cimetidine be adjusted when administered to patients with impairment of renal function (1). However, no simple guideline is available, and appropriate attention to the patient's renal status or dosage adjustment, or both, is often not paid. Many reports on possible complications of Cimetidine therapy have involved the administration of normal or increased doses of Cimetidine to patients with renal failure (2). Other reports, including two...References1. MA K, BROWN D, MASLER D, and SILVIS S: Effects of renal failure on blood levels of Cimetidine. Gastroenterology 74:473-477, 1978 CrossrefMedlineGoogle Scholar2. MCMILLEN M, AMBIS D, and SIEGEL J: Cimetidine and mental confusion. TV Engl J Med 298:284-285, 1978 CrossrefMedlineGoogle Scholar3. DE GALOCSY C and VAN YPERSELE DE STRIHOU C: Pancytopenia with Cimetidine (letter). Ann Intern Med 90:274, 1979 LinkGoogle Scholar4. SILVER B and BELL W: Cimetidine potentiation of the hypoprothrombinemic effect of warfarin. Ann Intern Med 90:348-349, 1979 LinkGoogle Scholar5. FRESTON J: Cimetidine and granulocytopenia (editorial). Ann Intern Med 90:264-265, 1979 LinkGoogle Scholar6. CANAVAN J and BRIGGS J: Cimetidine clearance in renal failure in Cimetidine: Proceedings of the Second International Symposium on Histamine H2—Recptor Antagonists, edited by BURLAND WL, SIMKINS MD, Amsterdam-Oxford, Excerpta Medica, 1977, pp. 75-80 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GORDON D. LUK, M.D.; WENDY J. LUK, M.S.; THOMAS R. HENDRIX, M.D.Affiliations: Johns Hopkins University School of Medicine Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCimetidine and GranulopoiesisS. ERIDANI, M.D., I.D.A. JOHNSTON, M.R.C.P., S. VILLA, B.SC.Neurological and psychiatric side effects of cimetidine—report of 3 cases with review of the literatureCimetidine in Elderly PatientsCimetidineMisuse of CimetidineDrug Therapy in Renal Failure: Dosing Guidelines for Adults Part II: Sedatives, Hypnotics, and Tranquilizers; Cardiovascular, Antihypertensive, and Diuretic Agents; Miscellaneous AgentsWILLIAM M. BENNETT, M.D., RICHARD S. MUTHER, M.D., RICHARD A. PARKER, M.D., PETER FEIG, M.D., GAIL MORRISON, M.D., THOMAS A. GOLPER, M.D., IRWIN SINGER, M.D.Great reduction in renal function associated with cimetidinePRIMIDONE-INDUCED "URÆMIC FLAP"CLOSE COMPANY OR CHICKEN SOUP 1 June 1979Volume 90, Issue 6Page: 991-992KeywordsRenal failure ePublished: 1 December 2008 Issue Published: 1 June 1979 PDF downloadLoading ...