tbuckley/cabot-search huggingface dataset:
Does Physical Exercise Aggravate Hepatitis?
Authors: William M. Lukash
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Does Physical Exercise Aggravate Hepatitis?William M. Lukash, M.D., F.A.C.P., Raymond B. Johnson, M.D., Michael F. Fornes, M.D., Jack W. Millar, M.D., Nicholas E. ManosWilliam M. Lukash, M.D., F.A.C.P.Search for more papers by this author, Raymond B. Johnson, M.D.Search for more papers by this author, Michael F. Fornes, M.D.Search for more papers by this author, Jack W. Millar, M.D.Search for more papers by this author, Nicholas E. ManosSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-793_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute viral hepatitis continues to be a major cause of time loss from work in our Armed Forces personnel. A recent Vietnam experience showed that a long period of convalescence with restricted physical activity was not essential for the treatment of this disease. To further substantiate this clinical impression regarding physical activity, more sensitive serum enzyme levels were utilized to determine the effect of exercise on the course of hepatitis. Twenty-two normal controls and 46 hospitalized patients whose serum enzyme levels had returned to normal were studied. Determination of serum glutamic-oxalacetic transaminase, serum glutamic-pyruvic transaminase, total and direct bilirubin, total... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 793-793KeywordsAminotransferasesArmed forcesBilirubinConvalescenceEnzymesExerciseHepatitisHepatitis A Issue Published: 1 May 1970 PDF DownloadLoading ...
Schizophrenia sans frontieres: concepts of schizophrenia among French and British psychiatrists.
Authors: J van Os, P Galdos, G Lewis, M Bourgeois, A Mann
Journal: BMJ (1993)

OBJECTIVE--To compare the first admission rates for schizophrenia in England and France, and to compare the concept of schizophrenia held by practising British and French psychiatrists. DESIGN--Comparative study of incidence rates in England and France; and postal questionnaire survey of a sample of about 1 in 30 psychiatrists in the United Kingdom and in l9Aquitaine, France. SUBJECTS--All first admissions for schizophrenia to psychiatric hospitals in England and France 1973-82; 92 psychiatrists in the United Kingdom and 69 in France. MAIN OUTCOME MEASURES--Age adjusted first admission rates for schizophrenia between 1973-82; and opinions on the aetiology, diagnosis, and management of schizophrenia. RESULTS--First admission rates were much higher in France than in England before the age of 45, but lower after that age. Rates were falling in England over the 10 year period, while they were rising in France. In the questionnaire study English and French psychiatrists showed prominent differences of opinion for 31 out of 38 statements. The French sample did not diagnose schizophrenia after the age of 45 and endorsed psychoanalytical concepts. CONCLUSIONS--British and French psychiatrists use different diagnostic criteria and contrasting methods of treatment for schizophrenia. Differences in diagnostic criteria probably contribute towards the disparity in administrative incidence rates and time trends for schizophrenia in the two countries. Doctors in the European Community can now work in any country. Further work is needed to ensure psychiatrists are talking a common language.
THE CHADS2 SCORE PREDICTS NEW ONSET ATRIAL FIBRILLATION AND ISCHEMIC STROKE IN PATIENTS WITH PALPITATIONS WITHOUT STRUCTURAL HEART DISEASE
Authors: Yuk-Fai Lau, Chu-Pak Lau, Hung-Fat Tse, Chung-Wah Siu
Journal: Journal of the American College of Cardiology (2012)
Sudden infant death in Scotland.
Authors: A Scott, H Campbell, D Gorman
Journal: BMJ (1993)

investigations without priority, selection criteria, or cost-benefit considerations.The brief mention of vesicoureteric reflux gives no indication of which adults require investigation, and both here and in respect of investigation for renal scarring there seems to be confusion with paediatric practice.'Are we really to believe that adults require dimercaptosuccinic (DMSA) scans?
A small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity
Authors: Kuan-Ju Chen, Stephanie M. Wolahan, Hao Wang, Chao-Hsiung Hsu, Hsing-Wei Chang, Armando Durazo, Lian-Pin Hwang, Mitch A. Garcia, Ziyue K. Jiang, Lily Wu, Yung-Ya Lin, Hsian-Rong Tseng
Journal: Biomaterials (2010)
Neointima formation in stented baboon carotid arteries is reduced by bonded heparin: Correlation with decreased thrombogenicity
Authors: Nicolas A.F. Chronos, Keith A. Robinson, Andrew B. Kelly, Margaret Yoklavich, Stephen M. Rowland, Pallassana N. Narayan, Laurence A. Harker, Stephen R. Hanson
Journal: Journal of the American College of Cardiology (1996)
Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees
Authors: Marian E. Major, Harel Dahari, Kathleen Mihalik, Montserrat Puig, Charles M. Rice, Avidan U. Neumann, Stephen M. Feinstone
Journal: Hepatology (2004)

To study determinants of clinical outcome following HCV infection, viral kinetics, immune events, and intrahepatic cytokine markers were compared in 10 naive chimpanzees. Four of the animals cleared HCV; 6 developed persistent infections. All animals developed similar acute infections with increasing viremia from 1 to 2 weeks, followed by alanine aminotransferase (ALT) elevations and seroconversion. This viremia pattern consisted of a biphasic increase, a rapid slope (mean doubling time [t 2 ] = 0.5 days) followed by a slower slope after the second week (t 2 = 7.5 days). This slowing of virus replication correlated in all animals with increased intrahepatic 2′5′ oligoadenylate synthetase 1 (2OAS-1) messenger RNA (mRNA) levels and was independent of disease outcome. An effective control of virus replication was observed following increases in intrahepatic interferon γ (IFN-γ) mRNA and ALT levels. Although this control was associated in all animals with a 2-log decrease in virus titer, the timing occurred approximately 2 weeks later in the chronic group ( P &lt; .05). Additionally, while cleared infections were characterized by a continual decrease in virus titer, the titers in the persistent infections reached a steady state level of 10 4 to 10 5 RNA copies/mL. This inability of the immune response to sustain viral clearance in the persistent infections was associated with a reduced intrahepatic CD3e and monocyte-induced protein 1α (MIP-1α) mRNA induction. In conclusion , these data indicate that, regardless of outcome, chimpanzees generate responses that control HCV replication during the early and late acute phase. However, the pathogenesis of HCV may be determined by a more rapid onset of the induced response and the cell population that migrates to the liver. (Hepatology 2004;39:1709-1720.)
ROENTGEN EVIDENCE OF HEALING IN DUODENAL ULCER
Authors: DANIEL M. CLARK
Journal: JAMA (1934)

The most conspicuous defect in the present accepted methods for the management of peptic ulcer is the lack of any dependable means of establishing that the lesion is healed. The interval between the onset of symptomatic relief, which is usually effected within a few days after the institution of medical treatment, and the complete healing of the ulcer undoubtedly varies greatly, and the time at which the latter takes place in individual cases cannot be established by any known procedure. Besides enabling one to answer the patient's persistent question "Is my ulcer healed," such a procedure, if it could be brought to light, would result in other advantages. By its employment in a sufficiently large number of controlled cases, information might be gathered as to the relative effectiveness of the widely varying methods of treatment now in vogue, thus ending many an argument. The patient would be benefited more directly
Bortezomib-Based Versus Nonbortezomib-Based Induction Treatment Before Autologous Stem-Cell Transplantation in Patients With Previously Untreated Multiple Myeloma: A Meta-Analysis of Phase III Randomized, Controlled Trials
Authors: Pieter Sonneveld, Hartmut Goldschmidt, Laura Rosiñol, Joan Bladé, Juan José Lahuerta, Michele Cavo, Paola Tacchetti, Elena Zamagni, Michel Attal, Henk M. Lokhorst, Avinash Desai, Andrew Cakana, Kevin Liu, Helgi van de Velde, Dixie-Lee Esseltine, Philippe Moreau
Journal: Journal of Clinical Oncology (2013)

Purpose To characterize efficacy and safety of bortezomib-based versus nonbortezomib-based induction regimens through an integrated analysis of data from phase III studies in transplantation-eligible patients with previously untreated myeloma. Patients and Methods Patient-level data from the IFM 2005-01 (bortezomib-dexamethasone v vincristine-doxorubicin-dexamethasone [VAD] induction), HOVON-65/GMMG-HD4 (bortezomib-doxorubicin-dexamethasone v VAD), and PETHEMA GEM05MENOS65 (bortezomib-thalidomide-dexamethasone v thalidomide-dexamethasone) studies were pooled in an integrated analysis of efficacy and safety. Study-level data from the GIMEMA MM-BO2005 study (bortezomib-thalidomide-dexamethasone v thalidomide-dexamethasone) supplemented the integrated patient-level analysis. Key efficacy end points were post-transplantation complete plus near-complete response (CR+nCR) rate and progression-free survival (PFS). Results Patient-level data for 1,572 patients (bortezomib-based induction, n = 787; nonbortezomib-based induction, n = 785) were included. Post-transplantation CR+nCR rate was significantly higher following bortezomib-based versus nonbortezomib-based induction (38% v 24%; odds ratio, 2.05; P &lt; .001); the benefit remained similar (pooled odds ratio, 1.96) when GIMEMA MM-BO2005 data were included. Median PFS was 35.9 months versus 28.6 months with bortezomib-based versus nonbortezomib-based induction, respectively (hazard ratio, 0.75; P &lt; .001); 3-year overall survival (OS) rates were 79.7% and 74.7%, respectively (hazard ratio for OS, 0.81; P = .0402). Median duration of induction treatment was 11 weeks in both treatment groups. Rates of peripheral neuropathy during induction were 34% versus 17% (grade ≥ 3, 6% v 1%). Overall, 3% and 4% of patients died during bortezomib-based and nonbortezomib-based induction, respectively. Conclusion Bortezomib-based induction results in significant improvements in response and PFS/OS compared with nonbortezomib-based induction and is generally well tolerated, with a higher rate of peripheral neuropathy but no apparent increase in risk of death during induction.
Regional trauma systems
Authors: D. Yates
Journal: BMJ (1997)

In 1988 the Royal College of Surgeons published recommendations designed to improve the management of patients with major injuries.1 The Department of Health responded by supporting the development of a regional trauma service in North Staffordshire and commissioning an in depth analysis of its performance compared with the orthodox British model of care in two other centres in Lancashire and Humberside. Reviews were also undertaken of the cost effectiveness of helicopter ambulances and the role of minor injuries units. The college introduced courses in advanced trauma life support, and the Department of Health supported the extension of the major trauma outcome study, to provide comparative audit data on hospital performance.2

Although the analysis of the regional trauma service examined outcomes in 1990-3, the article by Nicholl and Turner in this issue provides the first opportunity for the general reader to review the data (p 1349).3 Some will conclude that this delay is due either to publication bias against the negative results or to uncertainty about their validity when compared with the very positive earlier report from the Stoke clinicians.4 Whatever the reason, the paper provides an opportunity to …
174 FUNCTIONAL CORE MODULATION FOLLOWING TREATMENT OF MINIMAL HEPATIC ENCEPHALOPATHY WITH L-ORNITHINE L-ASPARTATE: A POTENTIAL NOVEL MECHANISM OF ACTION
Authors: M.J. McPhail, R. Leech, V.P. Grover, J. Fitzpatrick, N.S. Dhanjal, B.K. Saxby, K. Wesnes, H.C. Thomas, R.J. Wise, S.D. Taylor-Robinson
Journal: Journal of Hepatology (2011)
House Dust Endotoxin and Allergic Sensitization in Children
Authors: Ulrike Gehring, Wolfgang Bischof, Bärbel Fahlbusch, Heinz-Erich Wichmann, Joachim Heinrich
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Section:ChooseTop of pageAbstract <<METHODSRESULTSDISCUSSIONAPPENDIXReferencesCITING ARTICLES
Splenomegaly in Thyrotoxicosis
Authors: Samuel P. Marynick
Journal: JAMA (1982)

To the Editor.—  Edward R. Eichner, MD, and Charles L. Whitfield, MD, presented an excellent algorithmic approach to the diagnosis of splenomegaly (1981;246:2858). However, there is one omission that strikes an endocrinologist immediately: thyrotoxicosis. In the article by Baldridge and Peterson (1927;88:1701) they describe 144 patients with exopthalmic goiter, of which 44 had palpable spleens. Other authors have reported the induction of lymphoid hyperplasia and splenomegaly by thyroxine in experimental animals. 1,2   In the 73 patients I have seen with thyrotoxicosis, there have been three with generalized prominent lymphadenopathy that resolved after correction of the thyrotoxicosis. Two of the 73 had easily palpable splenomegaly as well as thrombocytopenia and leukopenia, a syndrome previously reported. 3 One of the two with decreased platelets had undergone a splenectomy before it was discovered he had thyrotoxicosis. Splenomegaly resolved in the second patient when a euthyroid state was achieved following sodium iodide I 131
Still awaiting screening facts
Authors: M. Baum, H. Thornton, P. C. Gotzsche
Journal: BMJ (2010)

On 19 February 2009 we wrote a letter in the Times calling for the leaflet, Breast Screening: the Facts , to be rewritten because none of the invitations for screening told the truth about its harms and benefits.1 Two days later the Times reported that the national …
Changes to mental health care proposed
Authors: J. Warden
Journal: BMJ (1997)

Britain this week began a search for better ways to treat mental illness in the community with the publication of a green paper, Developing Partnerships in Mental Health . Recent homicides committed by people with mental illness have both raised public concern and exposed shortcomings in the present system of care in the community.

The government, while not abandoning the concept of care in the community, has now put forward four options to be considered by a new administration after the …
Pitfalls in the Diagnosis of Jaundice due to Carcinoma of the Pancreas or Biliary Tree
Authors: R. B. Stern, R. P. Knill-Jones, R. Williams
Journal: BMJ (1973)

Analysis of 56 patients with obstructive jaundice due to carcinoma of the pancreas or extrahepatic biliary tree showed that unexpected features were present in 25%. Presentation with painless jaundice was uncommon, and the symptoms were more often non-specific, with malaise, anorexia, and vomiting. Abdominal pain was frequent, and the condition was found in young patients. One-fifth presented with serum alkaline phosphatase levels of less than 30 K.A. units. Some had high serum aspartate aminotransferase levels, more characteristic of hepatocellular jaundice. A mathematical model may be helpful in correctly weighting these various criteria.
Erythrocyte sensitization with monomeric IgM in a patient with hemolytic anemia
Authors: Irma O. Szymanski, Sara R. Huff, Leslie G. Selbovitz, Geoffrey K. Sherwood
Journal: American Journal of Hematology (1984)

Abstract An automated antiglobulin test showed that erythrocytes of a patient with an acute episode of Coombs‐negative hemolytic anemia were strongly sensitized with nonagglutinating IgM molecules. The bound antibodies, after elution from red blood cell stroma, were found to be monomeric IgM, since they migrated with IgG molecules on an agarose column, although they were proved to be immunoglobulin M, not G, by a sensitive hemagglutination inhibition assay. The hemolysis subsided with steroid therapy, but ANA increased to a titer greater than 1,024 (with peripheral pattern) without other laboratory evidence of systemic lupus erythematosus. In addition, the patient demonstrated photosensitivity and non‐scarring alopecia. We consider that this appearance of erythrocyte autoantibodies consisting of monomeric IgM was a symptom of atypical SLE.
Secondary prevention for stroke and transient ischaemic attacks
Authors: Sumantra Ray, Alexander S F Doney, Ronald S MacWalter
Journal: BMJ (2004)

Research on preventing road traffic injuries in developing countries is neededEditor-The dedication of the World Health Organization's World Health Day 2004 to road safety is recognition of the global threat of road traffic injuries.Increasing population size, vehicle ownership, road infrastructure, and transnational transportation have created a substantial public health burden.However, little epidemiological research has been conducted into preventing road traffic injuries in developing countries.Currently global research and development funding per disability adjusted life year for HIV, asthma, and blindness are $26.2,$10.8, and $5.4, respectively, while only $0.40 for road traffic injuries. 1 Epidemiological studies of successful interventions preventing road traffic injuries have been conducted in developed countries. 2But to assume the same effectiveness in developing countries is inappropriate because of behavioural, vehicular, and environmental differences.A pooled analysis of street lighting intervention data from developed countries shows a protective effect, 3 particularly in pedestrian injury (relative risk 0.56), the most common road traffic injuries in developing countries.Annually, 1.2 million deaths are attributed to road traffic crashes, 85% occurring in developing countries. 4If an intervention such as street lighting could reduce deaths by as much as 30%, there is a potential to save thousands of lives.Various international aid agencies are investing in road infrastructure development.These initiatives could be coupled with the need to develop concrete epidemiological data.Innovative strategies, such as step wedge study design, 5 could lead to the evolution of an evidence based public health approach to this problem.
A British Medical Association Lecture ON TUMOURS OF THE CEREBRUM: Delivered before the Nottingham Division and the Nottingham Medico-Chirurgical Society, December 3rd, 1924
Authors: H. S. Souttar
Journal: BMJ (1925)

THE symnptomiis of cer-ebral tumours ar e so varied in formii and so complex in origin that it is difficult to present a view
Prostate cancer patients with BRCA2 mutation face poor survival
Authors: R. Dobson
Journal: BMJ (2008)

Survival among patients with prostate cancer who have a mutation of the BRCA2 gene is poor, with only one in four known carriers of the mutation alive 10 years after diagnosis.

The median survival from diagnosis among men with the mutation is four years, finds a new study, whose authors say it may be important to develop chemotherapies targeted at such men ( British Journal of Cancer doi: 10.1038/sj.bjc.6604453).

“The survival …
We must join forces with our patients
Authors: J. Tomlinson
Journal: BMJ (2012)

<h3>Abstract</h3> Network analysis methods are useful to better understand and contextualize relationships between entities. While statistical and machine learning prediction models generally assume independence between actors, network-based statistical methods for social network data allow for dyadic dependence between actors. While numerous methods have been developed for the R statistical software to analyze such data, deep learning methods have not been implemented in this language. Here, we introduce GCN4R, an R library for fitting graph neural networks on independent networks to aggregate actor covariate information to yield meaningful embeddings for a variety of network-based tasks (e.g. community detection, peer effects models, social influence). We provide an extensive overview of insights and methods utilized by the deep learning community on learning on social and biological networks, followed by a tutorial that demonstrates some of the capabilities of the GCN4R framework to make these methods more accessible to the R research community.
STRIKING IDIOSYNCRASY TO THE USE OF COCAIN IN THE EYE.
Authors: T. W. MOORE
Journal: JAMA (1906)

The patient here referred to has an idiosyncrasy for two drugs, quinin and cocain. Such susceptibility to quinin has been frequently reported, and I have seen several cases so afflicted, but I am not aware of any one being affected by cocain in this manner, and a cursory examination of the literature fails to reveal a similar case. During January, in testing the refraction of L. L., a bank clerk, aged 25, I had a nurse in the office instil a solution of homatropin, gr. ½, in ½ dram of 4 per cent. solution of cocain, one drop in each eye, repeated every five minutes until six drops were used. Just before using the last drop the nurse called my attention to the fact that the patient's eyes had become very much swollen. To my astonishment I found the lids so swollen that it was only after the greatest effort
Mycological and Clinical Evaluation of Griseofulvin for Chronic Onychomycosis
Authors: R. R. Davies, J. D. Everall, E. Hamilton
Journal: BMJ (1967)

When griseofulvin became available in 1959 a critical evaluation of its use in chronic tinea of the nail was begun.Since then 122 patients have been treated with a standard dose § (0.5 g. t.d.s. for one month followed by 0.5 g. b.d.) for a minimum of six months and 74 for two years.As the trial progressed it became evident that a longer course of treatment was required than that suggested in earlier reports on the efficacy of the drug-namely, Williams et al. (1958) and Blank et al. (1959).It was therefore decided to treat for two years and to follow up the patient for a further year without treatment.Those failing to take the drug consistently throughout the lengthy period of treatment were transferred to an " intermittent-dose group."Methods
Freeman Hospital: working to improve services
Authors: J S Yudkin
Journal: BMJ (1992)

empirical evidence that psychological aspects of cancer management are important to quality of life, it is perhaps time now to ask why these practices are not being incorporated routinely into cancer treatment.Counselling is now a mandatory part of HIV testing.We should be thinking along the same lines for those people with a prospective diagnosis of cancer.In people with advanced disease the potential for distress is obviously great.It seems, however, that a large proportion of long term survivors pay a high psychological price and continue to have problems many years after treatment has ended.2Given this, how can the problem be adequately addressed?Where physical health is concerned there can be few dissenters from the belief that prevention is better than cure, yet this principle is rarely extended to psychological health.There are many excuses as to why we should not provide this type of care as routine, ranging from assertions that "everyone will want it" through to claims that "nobody will accept it."To an extent this latter claim acts as self fulfilling: if psychological help is offered in a judgmental and stigmatised way it is no surprise that people are reluctant to accept it.Spiegal et al's group of women with metastatic breast cancer, like the Greer et al cohort, were shown to benefit from therapy.3Given the groaning weight of evidence, it may be time to stop finding reasons for these aspects of care to fail and take a serious look at some not so new initiatives and how they could potentially prevent the deteriora- tion in quality of life that seems associated with life threatening disease.