High-Dosage Vitamin E Supplementation and All-Cause Mortality
Authors: Antonio M. Possolo
Journal: Annals of Internal Medicine (2005)

Letters19 July 2005High-Dosage Vitamin E Supplementation and All-Cause MortalityAntonio M. Possolo, PhDAntonio M. Possolo, PhDFrom GE Global Research, Niskayuna, NY 12309.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-2-200507190-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Given the results of the dose–response analysis summarized in Miller and colleagues' Figure 3 (1), the authors observed that the 95% confidence band for the risk difference does not include 0 for dosages greater than 900 IU/d. They go on (in their Table 2) to derive pooled risk differences and ratios therefrom that suggest a statistically significant relationship between dosage of vitamin E supplementation and all-cause mortality. The authors are to be commended for listing the data they used, thereby facilitating the exploration of alternative analyses. The ability to do this is especially important here because the ...References1. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37-46. [PMID: 15537682] LinkGoogle Scholar2. Breslow NE, Day NE. Statistical Methods in Cancer Research. Volume 1: The Analysis of Case-Control Studies. Lyon, France: International Agency for Research on Cancer; 1980. Google Scholar3. Loader C. Local Regression and Likelihood. New York: Springer-Verlag; 1999. Google Scholar4. R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2004. Google Scholar Author, Article, and Disclosure InformationAffiliations: From GE Global Research, Niskayuna, NY 12309.Disclaimer: The analyses and the opinions described in this letter are solely those of the author, were developed by him on his personal time, are unrelated to the work he performs for his employer, and do not purport to represent any views or positions held by his employer (General Electric).Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality Edgar R. Miller III , Roberto Pastor-Barriuso , Darshan Dalal , Rudolph A. Riemersma , Lawrence J. Appel , and Eliseo Guallar High-Dosage Vitamin E Supplementation and All-Cause Mortality Ishwarlal Jialal and Sridevi Devaraj High-Dosage Vitamin E Supplementation and All-Cause Mortality Thomas Carter High-Dosage Vitamin E Supplementation and All-Cause Mortality Joseph E. Baggott High-Dosage Vitamin E Supplementation and All-Cause Mortality Edgar R. Miller III , Lawrence J. Appel , Eliseo Guallar , and Roberto Pastor-Barriuso Brief Communication: The Prevalence of High Intake of Vitamin E from the Use of Supplements among U.S. Adults Earl S. Ford , Umed A. Ajani , and Ali H. Mokdad An Editorial Update: Annus horribilis for Vitamin E Eliseo Guallar , Daniel F. Hanley , and Edgar R. Miller III High-Dosage Vitamin E Supplementation and All-Cause Mortality David H. Blatt and William A. Pryor High-Dosage Vitamin E Supplementation and All-Cause Mortality Koyamangalath Krishnan , Sharon Campbell , and William L. Stone High-Dosage Vitamin E Supplementation and All-Cause Mortality Harri Hemilä High-Dosage Vitamin E Supplementation and All-Cause Mortality Wee-Shiong Lim , Rajka Liscic , Chengjie Xiong , and John C. Morris High-Dosage Vitamin E Supplementation and All-Cause Mortality Connie Marras , Anthony E. Lang , David Oakes , Michael P. McDermott , Karl Kieburtz , Ira Shoulson , Caroline M. Tanner , and Stanley Fahn High-Dosage Vitamin E Supplementation and All-Cause Mortality Simin Nikbin Meydani , Joseph Lau , Gerard E. Dallal , and Mohsen Meydani High-Dosage Vitamin E Supplementation and All-Cause Mortality Kent J. DeZee , William Shimeall , Kevin Douglas , and Jeffrey L. Jackson Metrics Cited ByNutrient plasma levels achieved during treatment that reduces noise-induced hearing lossBioactive Nutritional Supplements for Chronic Kidney Disease: Potential Cost BenefitsAdverse effects of vitamin E by induction of drug metabolismCellular, molecular and clinical aspects of vitamin E on atherosclerosis preventionVitamin E Regulatory Mechanisms 19 July 2005Volume 143, Issue 2Page: 154KeywordsConflicts of interestRegression analysisVitamin E ePublished: 19 July 2005 Issue Published: 19 July 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...