Empiric Carbenicillin, Gentamicin and Cephalothin Therapy for Presumed Infection in Patients with Granulocytopenia and Cancer.
Authors: W. H. Greene
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Empiric Carbenicillin, Gentamicin and Cephalothin Therapy for Presumed Infection in Patients with Granulocytopenia and Cancer.W. H. Greene, M.D., S. C. Schimpff, M.D., V. M. Young, M.D., P. H. Wiernik, M.D.W. H. Greene, M.D.Search for more papers by this author, S. C. Schimpff, M.D.Search for more papers by this author, V. M. Young, M.D.Search for more papers by this author, P. H. Wiernik, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-825_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of empiric, broad-spectrum antibiotic therapy in the treatment of presumed Gram-negative sepsis is nowhere more necessary than in the granulocytopenic patient, for without such therapy early (48 to 72 hours) death rates may exceed 50%. Since February 1971 the combination of carbenicillin, gentamicin, and cephalothin has been empirically applied to granulocytopenic (less than 1500/mm3), febrile (more than 38.3 °C [101 °F]) cancer patients at the first clinical suspicion of sepsis. In the ensuing 18 months 89 patients were treated for 177 such episodes, of which 103 were evaluable. (Nonevaluability was equated with either nonbacterial infection or no demonstrable... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFever and granulocytopenia in children with cancer: A study of 299 episodes with two treatment protocols in BrazilCeftazidime Combined with a Short or Long Course of Amikacin for Empirical Therapy of Gram-Negative Bacteremia in Cancer Patients with GranulocytopeniaBacterial Infections in Neutropenic PatientsStaphylococcus epidermidis: An Increasing Cause of Infection in Patients with GranulocytopeniaJAMES C. WADE, M.D., STEPHEN C. SCHIMPFF, M.D., KATHRYN A. NEWMAN, R.N., M.S., PETER H. WIERNIK, M.D.Piperacillin or ticarcillin plus amikacinCombinations of antibiotics for therapy of severe infections in cancer patientsPotential of mezlocillin as empiric single-agent therapy in febrile granulocytopenic cancer patientsFever and neutropenia in children with neoplastic disease an analysis of 158 episodesDuration of empiric antibiotic therapy in granulocytopenic patients with cancerInfection in the Compromised HostSepticemia in acute leukemiaKomplikationen und supportive Therapie der Leukämien und malignen Non-Hodgkin-LymphomeThe Management of Infections in the Hematologically Compromised PatientTherapy of Infection in Patients with GranulocytopeniaFever, neutropenia and malignancy: A clinical syndrome in evolutionSupportive Care in the Cancer PatientUse of Combinations of Antibiotics for Severe Infectionsin Cancer PatientsThe Use of Synergistic Combinations of Antibiotics in Patients with Haematological DiseasesCost analysis of leukemia treatment. A problem-oriented approachThe Therapy of Acute Leukemia in the Adult A Progress ReportDIAGNOSIS OF INFECTION IN PATIENTS WITH CANCERInfections in cancer patientsInfection Prevention in Acute Nonlymphocytic Leukemia Laminar Air Flow Room Reverse Isolation with Oral, Nonabsorbable Antibiotic ProphylaxisSTEPHEN C. SCHIMPFF, M.D., F.A.C.P., WILLIAM H. GREENE, M.D., VIOLA MAE YOUNG, Ph.D., CLARENCE L. FORTNER, M.S., LOIS JEPSEN, R.N., NANCY CUSACK, JEROME B. BLOCK, M.D., PETER H. WIERNIK, M.D.Complications and total care of a child with acute leukemia 1 May 1973Volume 78, Issue 5Page: 825-826KeywordsAntibioticsDeath ratesSepsis Issue Published: 1 May 1973 PDF DownloadLoading ...