tbuckley/cabot-search huggingface dataset:
Depression of Cardiac Function and Altered Myocardial Metabolism After Ethanol.
Authors: Timothy J. Regan
Journal: Annals of Internal Medicine (1964)

s1 April 1964Depression of Cardiac Function and Altered Myocardial Metabolism After Ethanol.Timothy J. Regan, M.D., Christos B. Moschos, M.D., Pablo Casanegra, M.D., Gabriel Koroxenidis, M.D., Harper K. Hellems, M.D., F.A.C.P.Timothy J. Regan, M.D.Search for more papers by this author, Christos B. Moschos, M.D.Search for more papers by this author, Pablo Casanegra, M.D.Search for more papers by this author, Gabriel Koroxenidis, M.D.Search for more papers by this author, Harper K. Hellems, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-709_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn view of the ill-defined status of cardiac involvement in chronic alcoholism, a study of the acute effects of ethanol on myocardial metabolism and function has been undertaken in animals considered nutritionally normal. The transport of various substrates by the left ventricle was studied for a 5-hr period in ten intact dogs. Fifteen per cent ethanol was infused for 2 hr at a rate of 0.1 ml/kg/min. Simultaneous arterial-coronary sinus sampling was performed at 15-min intervals. Observations were made of enzyme and ion leakage from heart muscle for evidence of necrosis, and the maximum rate of left-ventricular pressure rise was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Timothy J. Regan, M.D.; Christos B. Moschos, M.D.; Pablo Casanegra, M.D.; Gabriel Koroxenidis, M.D.; Harper K. Hellems, M.D., F.A.C.P.Affiliations: Jersey City, New Jersey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTimothy J. ReganAmelioration of Cardiotoxic Effects of Alcohol by Vitamin EAlcohol-induced prinzmetal variant anginaThe effect of ingestion of ethyl alcohol, wine and beer on the myocardium of miceAcute hemodynamic effects of ethanol on normal human volunteersThe Concept of Alcoholic MyocardiopathyAlcohol and the HeartCARL S. ALEXANDER, M.D.Alcoholism and the heartMyocardial depression accompanying chronic consumption of alcoholIdiopathic heart diseaseIdiopathic heart diseaseAlcoholic cardiomyopathy a histochemical study 1 April 1964Volume 60, Issue 4Page: 709-710KeywordsAlcoholismEnzymesEthanolLeft ventricleMyocardiumNecrosisNutrition ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
Ketanserin in the treatment of traumatic vasospastic disease.
Authors: V H Larsen, J Fabricius, G Nielsen, K S Hansen
Journal: BMJ (1986)

The specific serotonin receptor blocker ketanserin was given orally to 12 patients with traumatic vasospastic disease in a double blind crossover study. The effect of treatment was assessed by measuring finger systolic pressure and rewarming time after cold provocation and by medical interview and diaries. Median (range) percentage change in finger systolic pressure after cooling was 50 (0-100)% after treatment with ketanserin compared with 0 (0-90)% after placebo. Median (range) rewarming time after cooling decreased from 320 (236-972)s with placebo to 160 (88-404)s after treatment with ketanserin. These changes were not significant. Ninety five percent confidence intervals for difference between the treatments, however, showed that finger systolic pressure may be 80% better and rewarming time 256 seconds faster after treatment with ketanserin than after placebo. The number of attacks did not differ significantly between the two treatments. Two patients had a feeling of warmth in their hands during treatment with ketanserin. The results suggest that orally administered ketanserin may improve digital circulation in patients with traumatic vasospastic disease, but larger numbers of patients are required to assess the true effect of treatment with ketanserin in this disease.
Therapeutic pancreatic endoscopy after Whipple resection requires rendezvous access
Authors: T. Kinney, R. Li, K. Gupta, S. Mallery, D. Hunter, E. Jensen, S. Vickers, M. Freeman
Journal: Endoscopy (2009)

Whipple pancreaticoduodenectomy is an intricate surgical procedure that has traditionally carried a high morbidity and mortality. Despite advances in surgical techniques, the pancreaticojejunal anastomosis remains the "Achilles heel" of the surgery, and complications including acute duct leaks, stricturing of the pancreaticojejunostomy, and chronic pancreatic fistulae are not uncommon [1] [2] [3] [4] [5]. Acute duct leaks can often be managed conservatively with percutaneous drainage, whereas chronic strictures and fistulae may require more aggressive intervention. When re-operation and surgical revision of the pancreaticojejunal anastomosis is not possible, the only surgical option may be completion total pancreatectomy with or without islet cell autotransplantation [2] [3].
ENSAYO CLINICO ALEATORIZADO Y CIEGO COMPARANDO PICOSULFATO SÓDICO (CITRAFLEET®) Y MACROGOL 3350 (MOVIPREP®) EN LA PREPARACIÓN PARA COLONOSCOPIA
Authors: F Martínez de Juan, C Martínez Lapiedra, F Maia de Alcantara, V Picazo Ruíz, M Acedo Hidalgo, Y Alcaraz Serrano, P Carrau Mellado
Journal: Endoscopy (2011)

Introducción: la preparación es fundamental en la calidad de la colonoscopia. Existen pocos estudios que comparen los evacuantes más utilizados en nuestro medio: picosulfato sódico(CITRAFLEET®) y macrogol 3350 (MOVIPREP®).
Commercial aircraft cabin altitude
Authors: Michael Bagshaw
Journal: Journal of the Royal Society of Medicine (2007)

It was a pleasure to read the review in JRSM1 of an aviation medicine topic based on fact rather than emotional opinion. However, when considering the aircraft cabin environment it is incorrect to state that the cabin pressure is standardized to an equivalent of 8000 feet.

The regulations2,3 stipulate that the maximum cabin altitude should not exceed 8000 feet during normal operations, and, in fact, at usual cruising altitude the cabin altitude rarely exceeds 6000 or 7000 feet in a modern jet airliner.

Finally, the authors should have credited Boeing as well as Airbus with announcing a maximum design cabin altitude of 6000 feet, which they did for the new Boeing 787.
EFFECTS OF LYMPHOKINES ON FIBRINOLYSIS AND KININ GENERATION IN HUMAN PLASMA
Authors: SÁNDOR SIPKA, TIBOR SZILÁGYI
Journal: Allergy (1977)

Supernatants from Con-A-stimulated human lymphocytes containing leukocyte migration inhibitory factor, skin reactive factor and procoagulant activities were tested for their effect on fibrinolysis and kinin generation. The supernatants of stimulated lymphocytes activated the fibrinolysis and generated kinin in human plasma. These results are discussed from the aspect of cell-mediated (type IV) immune inflammation.
International Union of Pharmacology. L. Nomenclature and Structure-Function Relationships of CatSper and Two-Pore Channels
Authors: David E. Clapham, David L. Garbers
Journal: Pharmacological Reviews (2005)

CatSper channels (CatSper1-4) are named after the first putative cation channel of sperm ([Quill et al., 2001][1]; [Ren et al., 2001][2]). CatSpers are putative six-transmembrane (6TM[1][3]) voltage-gated Ca2+-permeant channels and seem to be specific to sperm cells. CatSper1 and 2 are each
Observation of Nucleogeminy in Urinary-Sediment Cells in the Roseola-Infantum Syndrome
Authors: Ruben Foster Gittes
Journal: New England Journal of Medicine (1963)

THE presence of two distinct nuclei in a majority of the epithelial cells in a urinary sediment was first observed in the course of routine urinalysis of a child with a nonspecific rash similar to that of roseola infantum and bacterial bronchopneumonia. The phenomenon of binucleated cells is here referred to as nucleogeminy. A search for further examples of the same phenomenon yielded 4 more cases, all associated with a viral exanthem. The apparent clinical diagnosis in 4 of the 5 cases was roseola infantum, and in the fifth case a diagnosis of measles had been made.This limited study . . .
Joy of rapid responses: … but perhaps not entirely effective
Authors: Leisha Wharfield
Journal: BMJ (2004)

Random drug testing in schools fails screening criteriaEditor-Last month the prime minister, Tony Blair, lent his weight to random drug testing in schools in an interview for a downmarket newspaper. 1He proposed a national programme be implemented soon, adhering to unspecified central directives.The Department of Health has 19 criteria for introducing new screening programmes. 2 At least 18 of these 19 criteria are not met for widespread, wide spectrum drug urine analysis in schools.The remaining criterion is that the condition is an important health problem.Drug use in young people is indeed associated with many health risks, 3 but a single, positive urine test, for any illicit drug, is probably not meaningful in a clinical sense.Each schoolchild's context of use (family history, social and emotional development) is crucial to interpreting any supposed "drug career."Use by a homeless pregnant teenage runaway from local authority care with a history of deliberate self harm and high risk sex work to pay for her drugs may be very different from a single experimental use at home with adults during a family party.Three failed criteria are especially pertinent to screening for school age drug use:(1) There should be an agreed policy on the further diagnostic investigation of people with a positive test result and on the choices available to them.(2) There should be an effective treatment or intervention for patients identified through early detection.(3) Clinical management of the condition and patient outcomes should be optimised by all healthcare providers before participation in a screening programme.In three years of experience of school health provision for alcohol and drug problems and their related referral networks I do not know of one school that could satisfy these criteria, especially the underpinning policy of promoting informed choice for children and families. 2
Gamma Globulin
Authors: Alta Ashley
Journal: New England Journal of Medicine (1954)

DURING the period January 1, 1952, through April 15, 1953, 671 cases of infectious hepatitis were reported to have occurred in Maine. This was far in excess of the number known to have occurred over a similar previous period though no true incidence was known before 1948, when the disease became reportable. In 1947 a small localized epidemic, involving an estimated 100 cases, had appeared in the southwest portion of the State. In 1949, the first full year of reporting, 17 cases were reported; there were 7 cases in 1950 and 21 in 1951.The incidence was somewhat higher during . . .
The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background
Authors: Edward K. Novak, Rashi Gautam, Madonna Reddington, Lucy M. Collinson, Neal G. Copeland, Nancy A. Jenkins, Michael P. McGarry, Richard T. Swank
Journal: Blood (2002)
Clinical Disorders of the Heart Beat. A Handbook for Practitioners and Students.
Authors: Thomas Lewis
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Localization of 99mTc-Pyrophosphate in an Ischemic Leg
Authors: ALAN J. SIMPSON
Journal: Clinical Nuclear Medicine (1977)

The localization of bone seeking radiopharmaceuticals in a variety of extraosseous lesions is well recognized. Specific accumulation in ischemic or infarcted tissue of the heart, brain and intestine has been reported. Two cases which demonstrate localization of 99mTc-pyrophosphate in the soft tissues and bone in an arterial thrombosed leg are reported.
Observations ON THE ETIOLOGY AND TREATMENT OF SEBORRHOEIC ERUPTIONS: A Preliminary Report
Authors: H. W. Barber, H. C. Semon
Journal: BMJ (1918)

T'HE widespread distribution and intractability of sebor- hliocic eruptions among troops on active service will sufficiently excuse the early publication of soine new conceptions as to their nature and treatment.The condition is very prevalent, and Major
Changes in Serum Cholesterol During the Stillman Diet
Authors: Frank Rickman
Journal: JAMA (1974)

In their quest to lose unwanted weight, more than 5 million people have purchased copies of Stillman's book:<i>The Doctor's Quick Weight Loss Diet</i>. The Stillman diet consists almost totally of protein and animal fat. The impact of this diet on serum cholesterol and triglyceride levels is unknown. The serum lipid levels of 12 healthy volunteers were monitored while they followed the Stillman diet for 3 to 17 days (average, 7.6 days). There was a transient weight loss that averaged 3.1 kg (7 lb). The serum cholesterol increased in every case, from an average base line of 215 mg/100 ml to 248 mg/100 ml during the diet (<i>P</i>&lt;.001). There were no considerable changes in serum triglycerides. The use of the Stillman diet with its resultant hypercholesterolemia presents potential risks, particularly to patients with overt or subclinical coronary artery disease. (<i>JAMA</i>228:54-58, 1974)
THE PATHOGENESIS OF RHEUMATIC FEVER
Authors: Homer F. Swift
Journal: The Journal of Experimental Medicine (1924)

It is evident that there are two distinct types of response on the part of the body to the infectious agent of rheumatic fever; viz., proliferative and exudative. The perivascular proliferative type of lesion, resembling an infectious granuloma, explains the subacute and chronic character of the clinical symptoms in many patients with this disease. Marked exudation of serum into the periarticular tissues and of serum and cells into the joint cavities are concomitants of the acute arthritis occurring with high fever and general intoxication; these acute exudations disappear following the administration of certain drugs. But their disappearance does not mean necessarily that all lesions of the proliferative type have resolved. In fact, we know that these last mentioned lesions, when present in the subcutaneous tissues, often continue for months; and from analogy we may conclude that they have a similar persistent character in other tissues of the body invaded by the causative agent of rheumatic fever.
Properties of the mouse α-globin HS-26: Relationship to HS-40, the major enhancer of human α-globin gene expression
Authors: Eric E. Bouhassira, Menno F. Kielman, John Gilman, Mary F. Fabry, Sandy Suzuka, Ofelia Leone, Ekatarinas Gikas, Luigi F. Bernini, Ronald L. Nagel
Journal: American Journal of Hematology (1997)

HS-26, the mouse homologue of HS-40, is the major regulatory element of the mouse α-globin gene locus. Like HS-40, HS-26 is located within an intron of a house-keeping gene; comparison of the nucleotide sequences of HS-26 and HS-40 reveals conservation of the sequences and positions of several DNA binding motifs in the 5′ regions of both elements (3 GATA, 2 NFE-2, and 1 CACCC sites) and the absence in HS-26 of three CACCC sites and one GATA site that are present in the 3′ region of HS-40, suggesting that the two elements might not be identical. We report here that when HS-26 is linked to a 1.5 kb Psti human α-globin gene fragment, it has a weak enhancer activity in induced MEL cells and in transgenic embryos, and it does not have any detectable activity in adult transgenic mice. This suggests that HS-26 does not have Locus Control Region (LCR) activity but can act as an enhancer during the embryonic life when integrated at a permissive locus. To further test the importance of HS-26 at its natural locus, we have generated embryonic stem cells and chimeric animals in which 350 bp containing HS-26 have been replaced by a neomycin resistance gene by homologous recombination. The sizes of the chimeras' red cells were then estimated by measuring forward scattering on a FacsScan apparatus in hypotonic conditions. This revealed that a fraction of the chimeric animals' red cells were smaller than normal mouse red cells and were very similar to cells from mice heterozygous for α-thalassemia. Density gradient analysis also suggested the presence of thalassemic cells. These results indicated that despite its lack of LCR activity, HS-26 is important for the regulation of the mouse α-globin gene locus. Am. J. Hematol. 54:30–39, 1997 © 1997 Wiley-Liss, Inc.
Heliox improves pulsus paradoxus and peak expiratory flow in nonintubated patients with severe asthma.
Authors: Constantine A. Manthous, Jesse B. Hall, Ari Melmed, Mark A. Caputo, James Walter, James M. Klocksieben, Gregory A. Schmidt, Lawrence D. H. Wood
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Heliox is a blend of helium and oxygen with a gas density less than that of air that decreases airway resistance (Raw) in patients ventilated for status asthmaticus. We tested whether breathing an 80:20 mixture of helium:oxygen would reduce pulsus paradoxus (PP) and increase peak expiratory flow (PEF) in patients presenting to the emergency room with an exacerbation of asthma. After receiving 30 min of beta-agonist aerosols and intravenously administered methylprednisolone, 27 patients whose PP remained greater than 15 mm Hg and whose PEF remained less than 250 L/min consented to breathe heliox or room air for 15 min. PP decreased and PEF increased with time in control patients, indicating a time-related effect of routine bronchodilator therapy (p < 0.05). PP decreased in 15 of 16 patients during heliox, and the change with heliox was significantly greater than that during air breathing (p < 0.01). PEF measured with a Wright's peak flow meter calibrated for heliox increased in all patients breathing heliox. Again, the increase in PEF during heliox breathing was significantly greater than the corresponding change in control patients breathing air (p < 0.001). To the extent that PP reflects the inspiratory fall in pleural pressure, this reduction in PP indicates a substantial reduction in inspiratory Raw when the less dense gas is inspired through narrowed bronchi having turbulent flow regimes. The 35% increase in PEF while breathing heliox signals a similar reduction in expiratory Raw, which might diminish the hyperinflation often observed during an exacerbation of asthma.(ABSTRACT TRUNCATED AT 250 WORDS)
Ca <sup>2+</sup> Uptake by the Sarcoplasmic Reticulum in Ventricular Myocytes of the <i>SERCA2</i> <sup>b/b</sup> Mouse Is Impaired at Higher Ca <sup>2+</sup> Loads Only
Authors: Gudrun Antoons, Mark Ver Heyen, Luc Raeymaekers, Peter Vangheluwe, Frank Wuytack, Karin R. Sipido
Journal: Circulation Research (2003)

SERCA2a is the cardiac-specific isoform of Ca2+-ATPase of the sarcoplasmic reticulum (SR). A reduction of SERCA2a has been implicated in the contractile dysfunction of heart failure, and partial knockout of the SERCA2 gene (Atp2a2+/- mice) reiterated many of the features of heart failure. Yet, mice with a mutation of Atp2a2, resulting in full suppression of the SERCA2a isoform and expression of the SERCA2b isoform only (SERCA2b/b), showed only moderate functional impairment, despite a reduction by 40% of the SERCA2 protein levels. We examined in more detail the Ca2+ handling in isolated cardiac myocytes from SERCA2b/b. At 0.25 Hz stimulation, the amplitude of the [Ca2+]i transients, SR Ca2+ content, diastolic [Ca2+]i, and density of ICaL were comparable between WT and SERCA2b/b. However, the decline of [Ca2+]i was slower (t1/2 154+/-7 versus 131+/-5 ms; P<0.05). Reducing the amplitude of the [Ca2+]i transient (eg, SR depletion), removed the differences in [Ca2+]i decline. In contrast, increasing the Ca2+ load revealed pronounced reduction of SR Ca2+ uptake at high [Ca2+]i. There was no increase in Na+-Ca2+ exchange protein or function. Theoretical modeling indicated that in the SERCA2b/b mouse, the higher Ca2+ affinity of SERCA2b partially compensates for the 40% reduction of SERCA expression. The lack of SR depletion in the SERCA2b/b may also be related to the absence of upregulation of Na+-Ca2+ exchange. We conclude that for SERCA isoforms with increased affinity for Ca2+, a reduced expression level is better tolerated as Ca2+ uptake and storage are impaired only at higher Ca2+ loads.
Chlorhexidine Gluconate for Prevention of Nosocomial Infection in Cardiac Surgery
Authors: William E. Scheckler
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spinal Cord Stimulation for Chronic Reflex Sympathetic Dystrophy — Five-Year Follow-up
Authors: Marius A Kemler, Henrica C W de Vet, Gerard A M Barendse, Frans A J M van den Wildenberg, Maarten van Kleef
Journal: New England Journal of Medicine (2006)

To the Editor: Reflex sympathetic dystrophy is a painful, disabling disorder of unknown pathophysiological origin that usually commences after trauma to or surgery on a limb. In chronic cases, the syndrome leads to extreme pain, disability, and an inability to work, symptoms that dramatically change the lives of both patients and their families.1,2 We undertook the present trial to determine whether treatment of chronic reflex sympathetic dystrophy with spinal cord stimulation and physical therapy is more effective than treatment with physical therapy alone. In spinal cord stimulation, an electrode is positioned in the epidural space on the dorsal aspect . . .