tbuckley/cabot-search huggingface dataset:
SOME QUANTITATIVE OBSERVATIONS ON THE ECZEMA REACTION.
Authors: G. H. PERCIVAL
Journal: British Journal of Dermatology (1933)

Journal Article SOME QUANTITATIVE OBSERVATIONS ON THE ECZEMA REACTION. Get access G. H. PERCIVAL, M.D., F.R.C.P. Edin. G. H. PERCIVAL, M.D., F.R.C.P. Edin. (From the Skin Department, Royal Infirmary, Edinburgh.) Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 45, Issue 2, 1 February 1933, Pages 49–58, https://doi.org/10.1111/j.1365-2133.1933.tb10140.x Published: 01 February 1933
BIPOLAR MULTI-ELECTRODE BALLOON CATHETER RADIOFREQUENCY RENAL DENERVATION WITH THE VESSIX SYSTEM: PRECLINICAL SAFETY EVALUATION
Authors: Gregory J. Wilson, Dawn Winsor-Hines, Radhika Tunstall, Barbara Huibregtse, Liza Davis, Jeannette Bankes
Journal: Journal of the American College of Cardiology (2014)
Long-term Cost-effectiveness of Various Initial Monotherapies for Mild to Moderate Hypertension
Authors: Jonathan T. Edelson
Journal: JAMA (1990)

To evaluate the comparative efficacy and cost-effectiveness of various antihypertensive medications in persons aged 35 through 64 years with diastolic blood pressure of 95 mm Hg or greater and no known coronary heart disease, we used the Coronary Heart Disease Policy Model, which is a computer simulation of overall mortality as well as the mortality, morbidity, and cost of coronary heart disease in the US population. From the pooled literature, we estimated the antihypertensive and total cholesterol effects of various antihypertensive regimens. For 20 years of simulated therapy from 1990 through 2010, the cost per year of life saved was projected to be $10,900 for propranolol hydrochloride; $16,400 for hydrochlorothiazide; $31,600 for nifedipine; $61,900 for prazosin hydrochloride; and $72,100 for captopril. Doubling the cholesterol effects of the agents under study did not significantly change their effectiveness because, in general, lowering diastolic blood pressure by 1 mm Hg was equivalent to lowering the cholesterol level by 6%. Although any projection requires multiple estimates, each of which may be open to debate, propranolol appears to be the preferred initial option under most of a variety of alternative assumptions.
Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.
Authors: L Voisin, D Breuillé, L Combaret, C Pouyet, D Taillandier, E Aurousseau, C Obled, D Attaix
Journal: Journal of Clinical Investigation (1996)

We studied the alterations in skeletal muscle protein breakdown in long lasting sepsis using a rat model that reproduces a sustained and reversible catabolic state, as observed in humans. Rats were injected intravenously with live Escherichia coli; control rats were pair-fed to the intake of infected rats. Rats were studied in an acute septic phase (day 2 postinfection), in a chronic septic phase (day 6), and in a late septic phase (day 10). The importance of the lysosomal, Ca2+ -dependent, and ubiquitin-proteasome proteolytic processes was investigated using proteolytic inhibitors in incubated epitrochlearis muscles and by measuring mRNA levels for critical components of these pathways. Protein breakdown was elevated during the acute and chronic septic phases (when significant muscle wasting occurred) and returned to control values in the late septic phase (when wasting was stopped). A nonlysosomal and Ca2+ -independent process accounted for the enhanced proteolysis, and only mRNA levels for ubiquitin and subunits of the 20 S proteasome, the proteolytic core of the 26 S proteasome that degrades ubiquitin conjugates, paralleled the increased and decreased rates of proteolysis throughout. However, increased mRNA levels for the 14-kD ubiquitin conjugating enzyme E2, involved in substrate ubiquitylation, and for cathepsin B and m-calpain were observed in chronic sepsis. These data clearly support a major role for the ubiquitin-proteasome dependent proteolytic process during sepsis but also suggest that the activation of lysosomal and Ca2+ -dependent proteolysis may be important in the chronic phase.
Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B
Authors: Stefan Fröhling, Richard F. Schlenk, Sabine Kayser, Martina Morhardt, Axel Benner, Konstanze Döhner, Hartmut Döhner
Journal: Blood (2006)
CS1-Directed Monoclonal Antibody Therapy for Multiple Myeloma
Authors: Don M. Benson, John C. Byrd
Journal: Journal of Clinical Oncology (2012)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2011.40.4061 Journal of Clinical Oncology - published online before print April 30, 2012 PMID: 22547601 CS1-Directed Monoclonal Antibody Therapy for Multiple Myeloma Don M. Benson JrxDon M. Benson JrSearch for articles by this author , John C. ByrdxJohn C. ByrdSearch for articles by this author Show More The Ohio State University Comprehensive Cancer Center, Columbus, OH https://doi.org/10.1200/JCO.2011.40.4061 First Page Full Text PDF Figures and Tables © 2012 by American Society of Clinical Oncology
Coagulation factor V and VIII/V ratio as predictors of outcome in paracetamol induced fulminant hepatic failure: relation to other prognostic indicators.
Authors: L M Pereira, P G Langley, K M Hayllar, J M Tredger, R Williams
Journal: Gut (1992)

The value of coagulation factor V and VIII/V levels as prognostic indicators was assessed in 27 patients with fulminant hepatic failure and compared with other predictive indices. Admission factor V levels were significantly reduced in 22 patients with paracetamol induced hepatic failure compared with a healthy control group (median 9.5% v 103%, respectively; p less than 0.001) and with lower values in non-A non-B hepatitis (median 2.7%). Values in the seven patients who died after paracetamol overdose, considered together with the four who underwent liver transplantation (group median 5.1%), were significantly lower than in the 11 who survived (median 11.8%; p less than 0.01). Median admission factor VIII was higher in those who died or received a transplant than in those who survived (298% v 162%; p less than 0.05), with both results higher than in healthy volunteers (median 104%; p less than 0.01) but lower than in non-A non-B hepatitis (median 340%). The ratio of factor VIII/V on admission was less than 30 in all patients who survived paracetamol overdose (median 17) with corresponding values greater than 30 in 10 of 11 of those who died (median 39). A factor V result less than or equal to 10% on admission predicted an adverse outcome in 10 of 11 fatal cases, a 91% sensitivity which was greater than for the previously defined indicator of an arterial blood pH less than 7.30 on admission (sensitivity 82%). Prothrombin time at admission or on day 4 did not usefully predict outcome in our series. Predictive accuracy was 73% and 82% for factor V and admission acidosis respectively and 95% for factor V in conjunction with admission coma grade III or IV and factor VIII (ratio > 30). These criteria may be useful in selecting patients with paracetamol induced fulminant hepatic failure for transplantation.
Spain's smoking restrictions spark tobacco price war
Authors: Sophie Arie
Journal: BMJ (2006)

Spain's effort to discourage smoking by banning it in the workplace and increasing taxes on cigarettes is not having quite the effect that the government intended.

Since the law went into effect on 1 January Spaniards have duly stopped smoking in offices, schools, and hospitals and on public transport and can now be seen lighting up in huddles on the pavements outside.

But a tax increase designed to make cigarettes more expensive and to discourage smoking has instead started a price war between companies determined to keep their place in the Spanish market.

Philip Morris, which makes Marlboro cigarettes, and Spain's top manufacturer, Altadis, have both lowered prices sharply.

The price …
Extensive Extraosseous Localization of Bone Imaging Agent in a Patient with Renal Failure and Rhabdomyolysis Accompanied by Combined Hypercalcemia and Hyperphosphatemia
Authors: WEI-JEN SHIH, JAMES FLUECK, WILLIAM O??CONNOR, PEGGY A. DOMSTAD
Journal: Clinical Nuclear Medicine (1989)

Four sequential Tc-99m pyrophosphate (PYP) imaging studies were performed in a 28-year-old man with high fever and exudate pharyngitis associated with renal failure. Radiotracer localization in the left ventricle (LV), lungs, kidneys, and skeletal muscles were seen in two, initial imaging studies. In the second and third imaging studies, area of increase in activity was seen in the left-sided bowel. In studies done two months later (in the third study), the radioactivity in the skeletal muscles was no longer seen. Studies obtained nine months (in the fourth study) after the first imaging showed less radiotracer localization in the LV, lungs, and kidneys as compared to that seen in the initial study. Myocardial necrosis and microcalcification were proved by LV biopsy. The exact mechanism of extraosseous bone-imaging agent localization is unknown. However, this phenomenon may be related to renal failure, rhabdomyolysis, hypercalcemia, hyperphosphatemia, or elevated parathyroid hormone. The Tc-99m PYP imaging study is useful and sensitive in the detection of extraosseous tissue calcification and monitoring of the disease process.
Telomerase and the Aging Cell
Authors: Michael Fossel
Journal: JAMA (1998)

Recent research has shown that inserting a gene for the protein component of telomerase into senescent human cells reextends their telomeres to lengths typical of young cells, and the cells then display all the other identifiable characteristics of young, healthy cells. This advance not only suggests that telomeres are the central timing mechanism for cellular aging, but also demonstrates that such a mechanism can be reset, extending the replicative life span of such cells and resulting in markers of gene expression typical of "younger" (ie, early passage) cells without the hallmarks of malignant transformation. It is now possible to explore the fundamental cellular mechanisms underlying human aging, clarifying the role played by replicative senescence. By implication, we may soon be able to determine the extent to which the major causes of death and disability in aging populations in developed countries—cancer, atherosclerosis, osteoarthritis, macular degeneration, and Alzheimer dementia—are attributable to such fundamental mechanisms. If they are amenable to prevention or treatment by alteration of cellular senescence, the clinical implications have few historic precedents.
Equitable access to health care
Authors: James K Tumwine
Journal: BMJ (2007)

As the world grapples with the problems of poverty and ill health most people would agree that urgent action is needed to reduce the unacceptably high number of deaths of children living in resource constrained countries. Three studies in this weeks BMJ provide evidence to improve health services in less resourced countries. The first study by Biai and colleagues is a randomised controlled trial from Guinea Bissau in West Africa. They show that supervising healthcare workers to adhere to standard treatment protocols reduces mortality in children admitted to hospital with severe malaria. This may not seem surprising. What is surprising though and of major policy importance is that a key part of this effective intervention was to provide a small financial incentive to health workers (equivalent to one months rent). Many agencies including governments in countries in sub-Saharan Africa with less resources have been reluctant to give financial incentives to their staff. They have opted instead for non-financial incentives such as acknowledging staff professionalism offering career development and training enforcing strict codes of conduct and setting benchmarks for performance-all to no avail. (excerpt)
Origin of the third heart sound. II. Studies in human subjects.
Authors: Y Ozawa, D Smith, E Craige
Journal: Circulation (1983)

We report noninvasive and invasive studies designed to clarify the mechanism of the third heart sound (S3) in humans. The noninvasive observations were made using a miniature accelerometer attached to the skin surface at the cardiac apex. In subjects with no S3, the tracings were either flat or showed very low undulations throughout diastole. Those with an S3, however, demonstrated a distinct reduction of acceleration, or negative jerk, of the rapid filling movement at the apex at the time of the sound. The invasive studies in the cardiac catheterization laboratory consisted of frame-by-frame measurements of left ventricular dimensions in the transverse and long axes during early diastole in patients with diastolic overload abnormalities to investigate the temporal sequence of filling in these two principal axes. The maximal long-axis filling rate occurred after the short axis, a finding that helps to resolve a discrepancy noted in the time of maximal short-axis filling and S3 production. These studies support the concept that the S3 is due to a sudden intrinsic limitation of longitudinal expansion of the left ventricular wall during early diastolic filling, resulting in a negative jerk that is transmitted to the skin surface.
Atlas of Aesthetic Plastic Surgery
Authors: Blair O. Rogers
Journal: JAMA (1974)

Little, Brown &amp; Company have added yet another excellent publication to their already growing library of books dealing with plastic surgery. In publishing this illustrated atlas of "cosmetic" or "esthetic" plastic surgical techniques, they have wisely chosen as its author one of the senior innovators in esthetic surgery in the United States today, Dr. John R. Lewis, Jr. His atlas owes a good deal of its usefulness to the simple, clear line-drawings of Mrs. Miriam Scharf Altmann. It should appeal chiefly to resident, junior and senior plastic surgeons whose training and skill in this specialty will be further enhanced by a careful reading of its contents from cover to cover. In addition, the book might help other surgeons in allied fields, such as otolaryngology, ophthalmology, and general surgery, to better understand the advances made in this subspecialty of cosmetic surgery ever since it originated in the United States and Europe
III. A Family Practice Program as a Basis for Training in the Clinical Program
Authors: Clark W. Wescoe
Journal: JAMA (1961)

YOU MAY well ask this morning why I was selected to speak for this program. At the moment I represent none of the areas of medical competence which are under discussion; indeed it might be claimed, and with some basis in fact, that I do not even represent medicine in general. I am not now, nor have I ever been, a family physician. The only family that conceivably would call upon my services is my own, and its members are much too sophisticated to be caught in such a blunder.  I am not now, nor have I ever been, a specialist in any of the clinical branches—although it is true that I received some training in internal medicine, training of which I am proud, training that I am certain was excellent, and training that has been of exceptional value to me in the various positions I have held since I
Abstract 457: Significance of angiotensin targeting on treatment of liver metastasis in colorectal cancer patients with diabetes
Authors: Hiroki Kuniyasu, Yi Luo, Yoshitomo Chihara, Hitoshi Ohmori, Kiyomu Fujii, Motokiyo Yoshikawa, Masaomi Kuwata, Kiyohide Fujimoto, Yoshihiko Hirao, Yasuhiko Kitadai
Journal: Cancer Research (2012)

Abstract We examined the effects of hyperglycemic conditions on liver metastasis of colorectal cancer (CRC). Angiotensin (AT)-II increased growth, invasion, and anti-apoptotic survival in HT29 and CT26 cells. In contrast, angiotensinogen (ATG) increased these features in HT29 cells but not in CT26 cells. HT29 cells expressed AT-II type 1 receptor, chymase, and rennin, whereas CT26 cells did not express renin. Renin expression and ATG-induced cell growth, invasion, and survival induced and increased as glucose concentration increased in HT29 cells and also CT26 cells. An inhibitor of renin or chymase abrogated A-II production in both cells. Reduction of hepatic ATG production by knockdown suppressed liver metastasis of HT29 cells. An examination of 121 CRC patients showed that diabetes in CRC cases was associated with higher blood HbA1c, higher renin and AT-II concentrations in the primary tumors, and higher incidence of liver metastasis than in nondiabetic cases. These results suggest that diabetes-associated AT activation enhances liver metastasis of CRC. We then examined an antimetastatic therapy by anti-AT treatments in CRC. In a streptozotocin-induced BALB/c mouse diabetes model that was fed a high-calorie diet, the blood sugar level increased and was associated with enhanced CT26 liver metastases. In this diabetic mouse model, liver metastasis of CT26 cells was suppressed by anti-AT treatment with a chymase inhibitor, a renin inhibitor, and an AT-II receptor blocker. Moreover, concurrent hypoglycemic and anti-AT treatments showed a synergistic inhibitory effect on CT26 cell liver metastasis. These results suggest that AT activation ability associated with diabetic conditions enhances liver metastasis of colon cancer. Therefore, treatment with anti-AT and hypoglycemic agents might be relevant for suppressing liver metastasis. This scheme should be examined in a clinical setting. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 457. doi:1538-7445.AM2012-457
Impact of solid discharges from coal usage in the southwest
Authors: D. G. Jones, I. R. Straughan
Journal: Environmental Health Perspectives (1978)

The Southwestern region of the United States is extremely wealthy in low sulfur coal resources which must be eventually utilized in response to national energy balance priorities. Fly ash and scrubber sludge can be safely disposed of using properly managed techniques to ensure that any potential impact from elements such as boron, molybdenum, or selenium is rendered insignificant. Alternative methods of solids utilization are presently being developed. Fly ash is presently being marketed commercially as an additive for concrete manufacture. Successful experiments have been completed to demonstrate the manufacture of commercial-grade wallboard from scrubber sludge. Also, greenhouse studies and field experiments have been conducted to demonstrate increased yields of selected crops grown on typical soils amended with fly ash in amounts ranging from 2% to 8%, by weight. These studies also indicate that barium and strontium may be good monitoring indices for determining atmospheric deposition of fly ash, due to their concentration ratios in soil and vegetation samples. Further studies are being conducted to confirm encouraging irrigation and crop-yield data obtained with fly ash amended soils. Finally, the composition of many fly ashes and soils are similar in the Southwest, and there are no anticipated solid discharges from coal usage which cannot be rendered insignificant with proper management of existing and emerging methods of treatment. Compared with the water availability impact of coal usage in the Southwest, the impact of solid waste discharges are insignificant.
The Medical Management of Clinical Endocardial Fibroelastosis
Authors: JAMES A. MANNING, FRANK J. SELLERS, RUFUS S. BYNUM, JOHN D. KEITH
Journal: Circulation (1964)

Fifty-six patients with the clinical diagnosis of primary endocardial fibroelastosis have been reviewed. There was an over-all mortality rate of 44 per cent and a long-term survival of 56 per cent. Of 31 long-term survivors, 27 are without cardiac symptomatology or cardiomegaly. The method and rationale of therapy are reviewed.
RESULTS OF ROENTGEN THERAPY IN CARCINOMA OF THE BREAST
Authors: GEORGE E. PFAHLER
Journal: JAMA (1930)

We have been using roentgen therapy in carcinoma of the breast since 1901, but, as this report is based on private cases, our records extend only from June, 1902, to June, 1926, which gives us 939 cases which have passed at least a three year period since the beginning of treatment. We have used only our private records because the cases in the hospital records have not been sufficiently followed.  Every medical observer has recognized the disappearance of both primary and recurrent malignant disease located in various parts of the body as a result of the action of the x-rays. All observers have also seen primary, recurrent and metastatic disease from carcinoma of the breast disappear. Gradually, the results from larger clinics are being reduced to statistics since beneficial results in individual cases are too common to excite interest.  In 1925, Pfahler and Widmann 1 presented before the American Roentgen
Socioeconomic outcome of subjects experiencing asthma symptoms at work
Authors: A. Larbanois, J. Jamart, J‐P. Delwiche, O. Vandenplas
Journal: European Respiratory Journal (2002)

The aim of this study was to investigate the socioeconomic outcomes of subjects who experienced work­related asthma symptoms in the absence of demonstrable occupational asthma (OA) and to compare these outcomes with those found in subjects with documented OA. Subjects (n=157) who were being investigated for work­related asthma, were surveyed. Of these 86 had OA, ascertained by a positive specific inhalation challenge (SIC), and 71 subjects had a negative SIC response. After a median interval of 43 months (range 12–85 months), the subjects were interviewed to collect information on employment status, income changes, and asthma­related work disability. Rates of work disruption and income loss at follow­up were similar in subjects with negative SIC (46% and 59%, respectively) and in those with OA (38% and 62%). The median loss as a percentage of initial income was 23% in subjects with negative SIC and 22% in subjects with OA. Asthma­related work disability, defined as any job change or work loss due to asthma, was slightly more common in subjects with OA (72%) than in those with negative SIC (54%). This study shows that, even in the absence of demonstrable occupational asthma, work­related asthma symptoms are associated with considerable socioeconomic consequences.
A Clinician's View of Neuromuscular Diseases
Authors: Fred A. Ziter
Journal: JAMA (1987)

Nine years have elapsed since the publication of the first edition of this book, and many of the changes that have occurred in the field of neuromuscular diseases are included in this new edition. However, the format remains the same, and the new, somewhat expanded version is even better than the original. This textbook describes the major neuromuscular diseases, exclusive of peripheral neuropathies, that produce muscle weakness in children and adults. The disorders covered include motor neuron diseases, disorders of neuromuscular transmission, muscular dystrophies and myotonias, inflammatory and metabolic myopathies, and congenital muscle diseases. An introductory chapter describes the general approach to diagnosis based on symptoms and signs and provides many helpful clues that Dr Brooke has garnered through years of experience. A new section dealing with exercise, muscle energetics, and various stress-testing techniques introduces and provides the foundation for the chapter on metabolic myopathies. The book has ample illustrations,