Mixed Cryoglobulinemia and Membranoproliferative Glomerulonephritis Associated with Hepatitis C Virus Infection
Authors: Edmundo Lopes
Journal: Annals of Internal Medicine (1996)

Letters1 November 1996Mixed Cryoglobulinemia and Membranoproliferative Glomerulonephritis Associated with Hepatitis C Virus InfectionEdmundo Lopes, MD, Lucila Lopes, V., MD, and Antonio Silva, Eduardo, MDEdmundo Lopes, MDEscola Paulista de Medicine 04023-900 Sao Paulo, Brazil.Search for more papers by this author, Lucila Lopes, V., MDEscola Paulista de Medicine 04023-900 Sao Paulo, Brazil.Search for more papers by this author, and Antonio Silva, Eduardo, MDEscola Paulista de Medicine 04023-900 Sao Paulo, Brazil.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-9-199611010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Response to interferon-α therapy has been reported in patients with mixed cryoglobulinemia (MC) and membranoproliferative glomerulonephritis (MPGN) associated with hepatitis C virus (HCV) infection, but relapses are frequent [1]. We describe a patient with HCV-related type II MC and MPGN who responded to treatment with ribavirin [2].A 49-year-old man with the nephrotic syndrome was referred to us for evaluation. For 8 years, he had been followed for hypertension, edema, hematuria, and proteinuria. Maintenance therapy included enalapril, clonidine, furosemide, and prednisone (10 mg daily). In 1993, HCV infection was diagnosed by the presence of antibody to HCV, ...References1. Misiani R, Beliavita P, Fenili D, Vicari O, Marchesci D, Sironi PL, et al. Interferon alfa-2a therapy in cryoglobulinemia associated with hepatitis C virus. N Engl J Med. 1994; 330:751-6. Google Scholar2. Reichard O, Andersson J, Schvarcz R, Welland O. Ribavirin treatment for chronic hepatitis C. Lancet. 1991; 337:1058-61. Google Scholar3. Johnson RJ, Willson R, Yamabe H, Couser W, Alpers CE, Wener MH, et al. Renal manifestations of hepatitis C virus infection. Kidney Int. 1994; 46:1255-63. Google Scholar4. Quigg R, Brathwaite M, Gardner D, et al. Successful cyclophosphamide treatment of cryoglobulinemic membranoproliferative glomerulonephritis associated with hepatitis C virus infection. Am J Kidney Dis. 1995; 25:798-800. Google Scholar Author, Article, and Disclosure InformationAffiliations: Escola Paulista de Medicine 04023-900 Sao Paulo, Brazil. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRemission of long-term hepatic and renal disease induced by HCV after direct-acting antivirals therapyA case of rapid amelioration of hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis treated by interferon-free directly acting antivirals for HCV in the absence of immunosuppressantHepatitis C as a systemic disease: virus and host immunologic responses underlie hepatic and extrahepatic manifestationsHepatitis C virus and lichen planusHepatitis C virus–related cryoglobulinemic glomerulonephritis: Long-term remission after antiviral therapyComplex management issues: management of HCV in the atypical patientRenal manifestations of hepatitis C infectionGlomerulonefrite associada à infecção pelo vírus da hepatiteCPrevalence of Cryoglobulinemia in Chronic Hepatitis C Virus Infection and Response to Treatment With Interferon-α 1 November 1996Volume 125, Issue 9Page: 781-782KeywordsAlanine aminotransferaseCyclophosphamideEdemaGlomerulonephritisHepatitis C virusInfectious hepatitisProteinuriaRNASerum albuminViral clearance Issue Published: 1 November 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...