tbuckley/cabot-search huggingface dataset:
Ulnar-sided wrist pain is not the only cause of TFCC injury: a clinical perspective on other diagnoses in the sport setting
Authors: J Read
Journal: British Journal of Sports Medicine (2013)

Diagnosing ulnar-sided wrist pain can be challenging due to the proximity of numerous anatomical structures that can all be injured, which cause pain or produce mechanical instability. Understanding the anatomy of the ulnar side of the wrist and the biomechanics of normal and dysfunctional movement are essential to accurate diagnosis and effective treatment.

So far the commonest presumptive diagnosis for ulnar-sided wrist pain has been triangular fibrocartilage complex (TFCC) injury. Though this may prove to be true the TFCC is not the only cause of pain around the ulnar side of the wrist. The rise in knowledge of the TFCC has been driven by an expanding body of research into this complex structure. A MEDLINE search for the term TFCC revealed no results until 1979, in the years 1980–1987 there were only six articles, this rose to 47 from 1988 to 1995 and between 1996 and now 244 articles have come into view. However, other causes of ulnar-sided wrist pain should not be overlooked. The purpose of this editorial is to give the reader a framework of basic science with which to approach this problem and to link in …
INHIBITION OF ANGIOTENSIN SIGNALING REDUCES INCIDENCE OF ANTIBODY MEDIATED ALLOGRAFT REJECTION.
Authors: Sanjay K. Shah, Divya Ratan Verma, Greg Snow, Abadallah G. Kfoury, Feras Bader, Kim Brunisholz, Stavros G. Drakos, Elizabeth ME Hammond, Monica P. Revelo, Edward Gilbert, Rami Alharethi, Deborah Budge, Melanie D. Everitt, Craig Selzman, Josef Stehlik
Journal: Journal of the American College of Cardiology (2010)
Lactation and breast cancer.
Authors: H Ratner
Journal: BMJ (1980)

assess this.We should be told how many patients receiving long-term anti-inflammatory therapy were examined in order to find the 249 patients who had no gastric lesions at the initial endoscopy, incorrectly named the pretreatment endoscopy.If few were rejected this would support the view that the lesions are often transient.We do not accept the authors' reasons for not including a control group, and would suggest the use of paracetamol in a group with osteoarthrosis.This is an important area of work in which much more information is required, but we would reluctantly question the conclusions drawn by these workers.Further studies of better design should be undertaken.
Treatment Given High Priority in New White House Drug Control Policy
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

JUST A FEW MONTHS AFTER HIS APpointment by President Obama as the new director of the White House Office of National Drug Control Policy (ONDCP), R. Gil Kerlikowske, former chief of the Seattle Police Department announced that after 4 decades, the “war on drugs” was over. “It’s time to recognize drug abuse and addiction for what it is—not just a criminal justice issue, but also a very complex and dynamic public health challenge, one that demands a systematic, comprehensive, and evidenceled approach if we are going to be equal to the task,” Kerlikowske said in a December speech (ht tp : / /www .whitehousedrugpolicy.gov/news /speech09/121009_Stockholm.pdf). Such statements and the appointment of a 35-year veteran of addiction treatment research, A. Thomas McLellan, PhD, as deputy director of ONDCP have lead to optimism that drug treatment would play a larger role in US drug policy. McLellan, cofounder of the Treatment Research Institute, a nonprofit organization that promotes the translation of addiction research into therapy, and editor in chief of the Journal of Substance Abuse Treatment from 20002009, recently discussed with JAMA the new direction at ONDCP. JAMA: There has been considerable progress in understanding the biological underpinnings of addiction in recent years. What role will this science play in the new policy? Dr McLellan: On the demandreduction side of the ONDCP strategy, we are going to be pushing prevention, early intervention, treatment, and recovery. Across all of those areas, the emphasis is evidence-based practice.
Immunoglobulin G heavy chain (Gm) allotypes in multiple sclerosis.
Authors: J P Pandey, J M Goust, J P Salier, H H Fudenberg
Journal: Journal of Clinical Investigation (1981)

Serum samples from 70 Caucasian patients with multiple sclerosis were typed for nine Gm markers. Significant association was found with the Gm 1,17;21 phenotype, and the relative risk for individuals with this phenotype was calculated at 3.6. The data indicate that Caucasians positive for Gm 1,17;21 are almost four times more likely to develop multiple sclerosis than those without this phenotype.
Lowered risk of dying of heart attack with third generation pill may offset risk of dying of thromboembolism
Authors: M. A Lewis, W. O Spitzer, L. A J Heinemann, K. D MacRae, R. Bruppacher
Journal: BMJ (1997)

Reported in this letter are the final results of a transnational case-control study on oral contraceptives (OCs) and myocardial infarction.  182 women 16-44 years of age with myocardial infarction were recruited to the study at 16 European centers in 1993-96; 635 hospital and community-based healthy women matched by age group and site served as controls.  Documented in linear trend analysis was a clear decrease in risk from first to third generation OCs.  The odds ratios (ORs) were 4.66 (95% confidence interval (CI) 1.52-14.33) for women who used first-generation OCs 2.99 (95% CI 1.51-5.91) for second-generation OCs and 0.85 (95% CI 0.30-2.39) for third-generation pills.  The OR for current use of third-generation OCs compared with current use of second-generation pills was 0.28 (95% CI 0.09-0.87).  Finally the OR for the risk of myocardial infarction was 7.2 (95% CI 4.6-11.4) when current smoking was adjusted for OC use.  The expected reduction in deaths from myocardial infarction associated with third-generation OCs should offset any excess deaths associated with venous thromboembolism.
Eligibility criteria for home treatment of DVT vary
Authors: D. R Vinson
Journal: BMJ (2001)

Two week rule for cancer referralsReducing waiting times from diagnosis to treatment might be more effectiveEditor-In their editorial on the two week rule for cancer referrals Jones et al discuss the fact that steps to meet the target for "urgent" referrals have led to a doubling of waiting time for "routine" cases. 1 This is exactly the result we would expect from our calculations modelling waiting times with a Monte Carlo model based on Poisson fluctuations in demand. 2 To sustain a waiting time below two weeks, capacity needs to exceed mean demand by approximately two patients a week for a wide range of values of mean demand.This applies to any appointment, including those for diagnostic and staging procedures, as well as for treatment.Applying this excess capacity to a subgroup of urgent referrals is inherently less efficient than applying it to reduce the waits for all patients.If a fast track for urgent referrals is created by transferring resources from routine cases, this is likely to lead to demand exceeding capacity for routine cases and hence to ever increasing waiting times.These calculations assume that variations are due to random fluctuations in a constant demand, which is an effective model for oncology referrals. 2There is some evidence from dermatology that reductions in waiting times lead to increase in demand, negating the benefit of increased resources. 3t might also apply to referrals for suspected cancer, in which case the extra capacity required will exceed our calculations.This effect should not apply to the number of cases of diagnosed cancer, which will be limited by the incidence of the disease.This suggests that resources may be more effectively targeted at reducing the waiting times from diagnosis to treatment than on reducing the time from referral by a general practitioner to diagnosis.
Group Ponders Genomics and Public Health
Authors: Xavier Bosch
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High Variability of Glycated Hemoglobin Concentrations in Patients With IDDM Followed Over 9 years: What is the best index of long-term glycemic control?
Authors: Baldev M Singh, Catherine McNamara, Peter H Wise
Journal: Diabetes Care (1997)

To determine variability of long-term glycemic control in patients with IDDM.A retrospective analysis of HbA1 among 122 IDDM patients followed over 9 years.Annual group mean HbA1 ranged from 8.4 to 9.3% with large standard deviations (1.7-2.0%), indicating marked variability among individuals. Fluctuations of more than +/- 1% HbA1 occurred in 50% of the patients year to year, and over 9 years the minimum-maximum range was > 3 and > 5% HbA1 in 55 and 11% of patients, respectively. In any one year, 22-43% of patients had HbA1 < 8%, but over 9 years only 3.3% were consistently < 8%. Groups divided according to baseline HbA1 of < 8, 8-10, and > 10% were significantly separated over 9 years by frequency distribution analysis of individual mean HbA1 but were indistinguishable when analyzed by individual HbA1 interquartile range (measure of variability).High variability of long-term glycemic control is a marked feature of IDDM, the extent of which may be relevant to microvascular risk.
Iodine-Labelled Fibrinogen Uptake Test
Authors: Edwin W. Salzman
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Your EDITORIAL entitled "Expanding Uses of the<sup>125</sup>I-Labelled Fibrinogen Uptake Test" (221:1162, 1972), unless specifically intended to tantalize and frustrate the reader, quite misses the point of the problem. What is needed is not yet another item in print applauding the method for its sensitivity, simplicity, and clinical value in diagnosis of venous thrombosis, but rather a means to make the radioactive product generally available in the United States. Many important studies using this method have been published from Europe, where the technique has been widely used. In this country, for fear of transmission of viral hepatitis, the Division of Biologic Standards has steadfastly refused to approve a commercial preparation for general distribution. The requirements for licensure are so intricate and tedious that no pharmaceutical firm has thus far been able or willing to satisfy them. The only applications of radioiodinated fibrinogen here have been with
Early effects of total paracentesis and albumin infusion on muscle sympathetic nerve activity in cirrhotic patients with tense ascites
Authors: Massimo Pozzi, Guido Grassi, Valeria Pecci, Carlo Turri, Giuseppe Boari, Giovanni Battista Bolla, Raffaella Dell'Oro, Sara Massironi, Luigi Roffi, Giuseppe Mancia
Journal: Journal of Hepatology (1999)
Gallbladder perforation with formation of hepatic subcapsular biloma, treated with endoscopic nasobiliary drainage
Authors: M. Tsai, T. Chen, M. Chang, T. Chen, C. Lin
Journal: Endoscopy (2010)

A 66-year-old man presented with right upper quadrant pain and progressive dyspnea for 2 days. He had history of chronic obstructive pulmonary disease and chronic kidney disease. On admission, he was febrile and had sinus tachycardia. Laboratory findings showed an elevated white blood cell count of 18.01 × 109/L with 92.1 % neutrophils. Liver function tests revealed normal alanine aminotransferase (14 U/L [3 – 37 U/L]), normal total bilirubin (0.6 mg/dL [0 – 1.0 mg/dL]), and elevated alkaline phosphatase (157 U/L [39 – 120 U/L]). Ultrasonography showed a big encapsulated cystic lesion in right upper quadrant of abdomen, with amorphous echogenic material within the lesion. The gallbladder was small in size and a 0.9-cm gallstone was noted ([Fig. 1]).
Prostheses after Amputation for Malignant Lesions
Authors: William F. Hickey, A. Arthur Rosse
Journal: New England Journal of Medicine (1955)

THE cost of an artificial limb, along with the expenses incident to a preliminary examination, x-ray studies, physiotherapy and, finally, training in the use of the limb, is a sizeable sum. As a result the question frequently arises whether it is medically advisable or economically sound to expend such a sum of money in behalf of a patient who has undergone an amputation because of a malignant process occurring in an extremity.It is a general impression among doctors that the prognosis for life in such patients is poor. However, because these cases are not very numerous, few persons or . . .
PWE-003 Colorectal Cancers Arising in Adenomas (“Polyp Cancers”) Discovered and Resected during Bowel Cancer Screening Colonoscopy: Abstract PWE-003 Table
Authors: A M Verma, P Wurm, A Dixon, K P West, A P Chilton
Journal: Gut (2013)

<h3>Introduction</h3> The national bowel cancer screening programme (BCSP) was rolled out in 2006. Screening is based on a guaiac FOBt strategy, positive tests are offered colonoscopy. In January 2008 implementation commenced in LNR region (pop ~1.6 million). Polyp cancers present a challenge both to clinicians and patients - optimal management remains unclear. We prospectively followed all patients who underwent primary endoscopic polypectomy. <h3>Methods</h3> Patients with polyp cancers resected by polypectomy alone within the BCSP (48 cases as of 31/12/11) have had their outcomes recorded (last update 31/10/12). <b>Results Demographic data</b> Mean/median age = 65.92/66 yrs Males/Females = 33 (68.75%)/15 (31.25%) Location of polyp cancer Rectum = 5 (10.4%)/Sigmoid = 41 (85.4%)/Desc colon = 2 (4.2%) <h3>Notes</h3> One patient with a Haggitt 1 polyp cancer has subsequently died from ascending colon adenocarcinoma (a new lesion). Of the 13 other polyp cancers, 5 were pedunculated but not assigned Haggitt levels due to incomplete excision or invasive cancer – one of these patients has subsequently died with liver metastases. There were 8 sessile polyp cancers with no recurrences – too small a group to draw any meaningful conclusions. <h3>Conclusion</h3> There were 26 patients with Haggitt 1 or 2 polyp cancers. Cumulative follow up of 73.3 yrs has not identified any case of recurrence, suggesting that endoscopic resection of these lesions is curative. The 9 patients with Haggitt 3 polyp cancers (invasion into stalk) have 30.3 yrs cumulative recurrence free time. It is recognised that there is an increased risk of adverse outcomes (lymph node metastasis/recurrence)<sup>1</sup> from Haggitt 4 polyp cancers (invasion into bowel wall submucosa below stalk) and hence factors such as adequate resection margins (despite diathermy artefact) and length of stalk have to be taken into account to ensure that Haggitt 3 polyp cancers are not actually Haggitt 4 polyp cancers. Patients with Haggitt 3 polyp cancers, where there is evidence of adequate resection margins, should be offered the option of conservative treatment balanced with the risks of formal resection. <h3>Disclosure of Interest</h3> None Declared <h3>Reference</h3> Haggitt RC, Glotzbach RE, Soffer EE, Wruble LD. Prognostic factors in colorectal carcinomas arising in adenomas: implications for lesions removed by endoscopic polypectomy. Gastroenterology 1985; 89:328–36.
Incidence, severity, and mortality of acute respiratory failure in Berlin, Germany.
Authors: K Lewandowski, J Metz, C Deutschmann, H Preiss, R Kuhlen, A Artigas, K J Falke
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

A prospective multicenter study was carried out from October 1 to November 30, 1991, to determine the incidence, severity, and mortality of acute respiratory failure (ARF) in Berlin, Germany, a metropolis with a population of 3.44 million. Adult patients from 72 intensive care units (ICUs) were evaluated. ARF was defined as: (1) intubation and mechanical ventilation (I+MV) > or = 24 h; age > or = 14 yr. Incidence of ARF was assessed as the number of patients fulfilling ARF criteria within the 2-mo study period. Severity of ARF was defined as "no lung injury" (NLI), "mild-to-moderate lung injury" (MMLI), and "severe lung injury" (SLI) according to Murray and coworkers' proposals. Mortality was assessed as number of patients with ARF dying during ICU stay. During the study period, 508 patients were diagnosed as having ARF, representing an incidence of ARF of 88.6 per 100,000/yr. Twenty-four h after I+MV, MMLI occurred in 94% and SLI in 3.6% of the ARF patients. Overall mortality rate was 42.7%. Mortality rate in the NLI group was 36.4%; in patients with MMLI, 40.8%; and in patients with SLI, 58.8%. Our data offer novel information on incidence, severity, and mortality of ARF in a major urban population.
Manual of Surgery of the Gallbladder, Bile Ducts, and Exocrine Pancreas
Authors: A. R. Moossa
Journal: JAMA (1980)

This manual represents the ambitious project of summarizing in a comprehensive fashion current thinking on and techniques of biliary and pancreatic surgery for surgeons, residents, and practitioners. It includes an account of the relevant anatomy and physiology as well as a review of diagnostic methods and operative management. I was at first skeptical and even cynical when I began this review and thought that no concise text could satisfy these objectives. Dr Hermann and his colleagues at the Cleveland Clinic have proved me wrong. Their extensive experience in biliary tract and pancreatic surgery is reflected throughout the text, which provides sound, rapid advice to the young surgeon in training who wishes to brush up on his facts before going to the operating room. Occasionally I was frustrated by the lack of in-depth information and discussion and had to remind myself that this text attempts simply to highlight approaches to patient
Imagine all the people
Authors: Des Spence
Journal: BMJ (2013)

“What do you see?” he breathed down my neck. I squinted down the microscope. All I saw was a collection of stained circular blobs where pancreas cells should be. We were supposed to sketch this in drawing books. “Elephants,” I exclaimed—for the exercise was rubbish as far as I was concerned, but histology was no place for the flippant. Next week, a friend winked at me and furtively pulled out a histology atlas. I beamed in appreciation. We traced round the photos of cell …
Severe esophageal burn after transesophageal pacing
Authors: H. Köhler, S. Zink, J. Scharf, A. Koch
Journal: Endoscopy (2007)

A 13-year-old girl with tachycardia and a 3-week history of fatigue and headaches was admitted with suspected myocarditis. Echocardiography showed a dilated left ventricle with a shortening fraction of 12 %. Electrocardiography revealed ectopic atrial tachycardia, with a heart rate of 200 beats per minute. Cardioversion was performed to terminate the tachycardia, but this was unsuccessful. Intravenous amiodarone was started, but within hours the girl had deteriorated. Verapamil and beta blockers were not suitable because of their negative inotropic effects, and so a transesophageal electrode catheter was placed under fluoroscopic guidance. Rapid atrial pacing (320/minute, 20 mA) resulted in atrioventricular block and the ventricular rate fell to 160 beats per minte. The amiodarone treatment was continued and sinus rhythm was achieved after 18 hours, when atrial pacing was stopped.
Profound hypothermia on combined lithium carbonate and diazepam treatment.
Authors: G J Naylor, A McHarg
Journal: BMJ (1977)

cell count 16 5 x 109/1 (16 500/mm3), 90% neutrophils; ESR 131 mm in the first hour; serum uric acid 0-15 mmol/l (2-5 mg/100 ml).Aspiration of fluid from the knee confirmed the presence of crystals.X-ray pictures showed chondrocalcinosis of knees, shoulders, and hips.There were streaks of calcification in the annulus fibrosus ligament of the lumbar spine.He was given phenylbutazone and immediately improved.Subsequent investigations showed a raised serum iron concentration and liver biopsy confirmed the diagnosis of haemochromatosis.Case 3-A 78-year-old man was admitted to hospital with a two-month history of pain in the neck and lower back accompanied by such severe stiffness that he could hardly move.Four years previously he had an episode of swelling of the left knee.All movements of the cervical and lumbar vertebrae were greatly limited and accompanied by severe pain.There was effusion in the left knee with warmth and tenderness.The white cell count was 8 0 x 109/1 (8000/mm3), and the ESR 42 mm in the first hour.Aspirate from the left knee showed calcium pyrophosphate crystals.X-ray examination of left knee showed chondrocalcinosis.He was treated with indomethacin, improved remarkably, and was discharged after only one week in hospital.
Tetrahydroaminoacridine–Lecithin Combination Treatment in Patients with Intermediate-Stage Alzheimer's Disease
Authors: Serge Gauthier, Rémi Bouchard, Albert Lamontagne, Peter Bailey, Howard Bergman, Jack Ratner, Yoseph Tesfaye, Monique Saint-Martin, Yves Bacher, Louise Carrier, Roland Charbonneau, A. Mark Clarfield, Brian Collier, Dolly Dastoor, Louise Gauthier, Marcel Germain, Catherine Kissel, Monique Krieger, Seymour Kushnir, Hélène Masson, Jacques Morin, Vasavan Nair, Leonard Neirinck, Samy Suissa
Journal: New England Journal of Medicine (1990)

We studied the efficacy and safety of oral tetrahydroaminoacridine (THA) combined with lecithin in 52 patients with Alzheimer's disease. The maximal tolerated dose of THA (up to 100 mg per day) was determined during an eight-week titration period, after which the tolerated dose of THA or placebo was given during two sequential randomized periods of treatment lasting eight weeks each. Highly purified lecithin (4.7 g per day) was administered during all phases of the study. Efficacy was expressed in terms of scores on the Mini—Mental State (MMS) test, the modified MMS test, the Hierarchic Dementia Scale, the Rapid Disability Rating Scale—ll, and the behavioral scale of Reisberg et al. Safety was assessed by careful clinical monitoring as well as serial measurements of liver aminotransferases.