tbuckley/cabot-search huggingface dataset:
OBSERVATIONS ON INFECTION BY PLASMODIUM KNOWLESI (APE MALARIA) IN THE TREATMENT OF GENERAL PARALYSIS OF THE INSANE
Authors: C. E. van Rooyen, G. R. Pile
Journal: BMJ (1935)

A male, aged 35 years, labourer, had been suffering from cardiac insufficiency for several years.When first seer., a few months before his death, he was suffering from heart failure.The pulse was regular and a bit rapid, and he was Cyanosed and dyspnoeic.The cardiac pulsations were seen
Autoradiographic analysis of GABA-benzodiazepine receptors in an animal model of acute hepatic encephalopathy
Authors: Martin Rössle, Jürgen Deckert, Anthony E. Jones
Journal: Hepatology (1989)

To complement analogous studies using conventional ligand-membrane binding assays, the densities of γ-aminobutyric acid and benzodiazepine receptors in the brain have been assessed using an autoradiographic technique in an animal model of hepatic encephalopathy. Hepatic encephalopathy due to fulminant hepatic failure was induced in rabbits by the intravenous injection of galactosamine. The specific binding of three radiolabeled ligands was assessed densitometrically in several microregions of cerebral cortex, hippocampus and cerebellum. [ 3 H]Muscimol was used to assess γ-aminobutyric acid receptor density and [ 3 H]flunitrazepam or [ 3 H]Ro 15-1788 was used to assess benzodiazepine receptor density. No significant differences were observed between the magnitude of binding of the three ligands to each of the microregions of brain from control rabbits and rabbits in Stage III or IV hepatic encephalopathy. These findings suggest that the behavioral expression of hepatic encephalopathy in the model studied is not dependent upon an increase in the number of γ-aminobutyric acid or benzodiazepine receptors, but do not conflict with the hypothesis that γ-aminobutyric acid-ergic tone is increased in hepatic encephalopathy.
Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm
Authors: Xuehui Huang, Yan Zhao, Xinghua Wei, Canyang Li, Ahong Wang, Qiang Zhao, Wenjun Li, Yunli Guo, Liuwei Deng, Chuanrang Zhu, Danlin Fan, Yiqi Lu, Qijun Weng, Kunyan Liu, Taoying Zhou, Yufeng Jing, Lizhen Si, Guojun Dong, Tao Huang, Tingting Lu, Qi Feng, Qian Qian, Jiayang Li, Bin Han
Journal: Nature Genetics (2011)
Guidelines for the clinical evaluation of hypersensitivity pneumonitis Report of the Subcommittee on Hypersensitivity Pneumonitis
Authors: H RICHERSON, I BERNSTEIN, J FINK, G HUNNINGHAKE, H NOVEY, C REED, J SALVAGGIO, M SCHUYLER, H SCHWARTZ, D STECHSCHULTE
Journal: Journal of Allergy and Clinical Immunology (1989)
Evolution of gypsy Endogenous Retrovirus in the Drosophila obscura Species Group
Authors: R P Vázquez-Manrique, M Hernández, M J Martínez-Sebastián, R de Frutos
Journal: Molecular Biology and Evolution (2000)

The Ty3/gypsy family of retroelements is closely related to retroviruses, and some of their members have an open reading frame resembling the retroviral gene env. Sequences homologous to the gypsy element from Drosophila melanogaster are widely distributed among Drosophila species. In this work, we report a phylogenetic study based mainly on the analysis of the 5′ region of the env gene from several species of the obscura group, and also from sequences already reported of D. melanogaster, Drosophila virilis, and Drosophila hydei. Our results indicate that the gypsy elements from species of the obscura group constitute a monophyletic group which has strongly diverged from the prototypic D. melanogaster gypsy element. Phylogenetic relationships between gypsy sequences from the obscura group are consistent with those of their hosts, indicating vertical transmission. However, D. hydei and D. virilis gypsy sequences are closely related to those of the affinis subgroup, which could be indicative of horizontal transmission.
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
Authors: Dana B Hancock, Mark Eijgelsheim, Jemma B Wilk, Sina A Gharib, Laura R Loehr, Kristin D Marciante, Nora Franceschini, Yannick M T A van Durme, Ting-hsu Chen, R Graham Barr, Matthew B Schabath, David J Couper, Guy G Brusselle, Bruce M Psaty, Cornelia M van Duijn, Jerome I Rotter, André G Uitterlinden, Albert Hofman, Naresh M Punjabi, Fernando Rivadeneira, Alanna C Morrison, Paul L Enright, Kari E North, Susan R Heckbert, Thomas Lumley, Bruno H C Stricker, George T O'Connor, Stephanie J London
Journal: Nature Genetics (2009)
Heparin in the Treatment of Burns
Authors: Michael J. Saliba
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Known since 1906 chiefly as an anticoagulant, heparin has serum lipid-clearing, anti-inflammatory, and antiallergenic properties.<sup>1-3</sup>Its molecule carries a strong negative charge and it is the strongest antihistamine known.<sup>1,3</sup>Dougherty has shown a chain reaction destruction of all living cells in tissue culture when some cells are injured. Heparin protects against this cellular lysis, presumably by inactivating histamine directly.<sup>3</sup>Heparin has been reported as useful in allergic reactions, weeping eczema, laryngeal tracheal bronchitis, and acute and chronic asthma.<sup>2-6</sup> By inferential thinking, heparin could be extremely helpful in the treatment of burns—a thermal trauma infamous for its high loss of fluids, electrolyte, and protein. To test this hypothesis, I treated burn patients as follows: Eight acutely burned patients with first-, second-, and third-degree burns were seen in my office immediately after the thermal burn injury. Blisters were forming in all cases. Some patients had
Tuberculosis-associated Severe CD4+ T-Lymphocytopenia in HIV-Seronegative Patients from Dakar
Authors: S.J Kony, A.A Hane, B Larouzé, A Samb, S Cissoko, P.S Sow, M Sané, M Maynart, G Diouf, J.F Murray, None the SIDAK Research Group
Journal: Journal of Infection (2000)
Mesoscopic and Macroscopic Optoacoustic Imaging of Cancer
Authors: Adrian Taruttis, Gooitzen M. van Dam, Vasilis Ntziachristos
Journal: Cancer Research (2015)

Optoacoustic imaging combines the rich contrast of optical methods with the resolution of ultrasound imaging. It can therefore deliver optical visualization of cancer far deeper in tissue than optical microscopy and other conventional optical imaging methods. Technological progress and novel contrast media have resulted in optoacoustic imaging being propagated to basic cancer research and in clinical translation projects. We briefly review recent technological advances, showcase the ability to resolve unique cancer biomarkers based on spectral features at different imaging scales, and highlight the imaging performance achieved in preclinical and clinical imaging applications. .
Formaldehyde exposure enhances inhalative allergic sensitization in the guinea pig
Authors: F. Riedel, E. Hasenauer, P. J. Barth, A. Koziorowski, C. H. L. Rieger
Journal: Allergy (1996)

Formaldehyde (FA), a common indoor air pollutant, has been associated with increased prevalence rates of asthmatic symptoms among exposed individuals in epidemiologic surveys. We studied the influence of FA exposure on inhalative allergic sensitization in the guinea pig. Three groups of guinea pigs ( n = 12 each) were exposed to clean air or two different FA concentrations (0.13 and 0.25 ppm) over 5 consecutive days. Exposure was followed by inhalation of 0.5% ovalbumin (OA) as sensitizing allergen. Three weeks later, specific bronchial provocation with OA was performed with body plethysmographic measurement of compressed air (CA). Furthermore, specific anti‐OA‐IgGI (reaginic) antibodies were determined in serum. In a further six animals, the respiratory tract was examined histologically for signs of inflammation directly after the end of FA or clean air exposure. In the group exposed to 0.25 ppm FA, 10/12 animals were found to be sensitized to OA (positive reaction on specific provocation) vs. 3/12 animals in the control group (P&lt;0.01). Furthermore, CA measurements of specific bronchial provocation and serum anti‐OA‐antibodies were significantly higher in the 0.25 ppm FA group than in controls (CA 0.35 vs. 0.09 ml median, P &lt;0.01; anti‐OA‐IgC1 13 vs. &lt;10 EU median, P &lt;0.05), indicating enhanced sensitization. In the group exposed to 0.13 ppm FA, no significant difference was found compared to the control group. There was no sign of inflammation of the lower airways in FA‐exposed guinea pigs other than mucosal edema, which was discovered by morphometry. We conclude that short‐term exposure to a low concentration of FA (0.25 ppm) can significantly enhance sensitization to inhaled allergens in the guinea pig.
Health insurance is "very important" to young US adults, poll finds
Authors: M. McCarthy
Journal: BMJ (2013)

Seven in 10 US adults aged 18-30 think that having health insurance is “very important” to them, a new poll shows.1

The findings should cheer the Obama administration, which is depending on the enrollment of healthy young adults to keep premiums of plans offered by the new insurance exchanges low.

The exchanges, a key provision of the 2010 Affordable Care Act, create online marketplaces where individuals and small businesses can shop for plans and obtain subsidies …
Coronary Disease and Hiatal Hernia
Authors: James C. Morris, Palmer F. Shelburne, Edward S. Orgain
Journal: JAMA (1963)

IT IS WELL DOCUMENTED that coronary insufficiency and hiatal hernia may produce identical chest pain.<sup>1-3</sup>However, it is less generally appreciated that when both conditions occur simultaneously there may be actual interplay between the esophageal disease and the coronary-artery disease. The purpose of this report is to describe a patient who had coronary insufficiency and a hiatal hernia; whose pain and classical ST-T changes in the electrocardiogram of myocardial ischemia were regularly induced by (1) exercise in the fasting state and (2) distention of the hernia with barium or with food with the patient in the recumbent position. Surgical correction of the hernia abolished both the pain and the electrocardiographic changes produced by the distention of the hernia with barium and food but did not affect the classical response to the exercise test. These observations offer evidence suggestive of the existence of a true viscerocardiac reflex. <h3>Report of a</h3>
Long-Term Response to Gefitinib and Crizotinib in Lung Adenocarcinoma Harboring Both Epidermal Growth Factor Receptor Mutation and <i>EML4-ALK</i> Fusion Gene
Authors: Rita Chiari, Simona Duranti, Vienna Ludovini, Guido Bellezza, Anjuta Pireddu, Vincenzo Minotti, Chiara Bennati, Lucio Crinò
Journal: Journal of Clinical Oncology (2014)
Abstract B40: MYCN/MYC protein expression in high-MKI (Mitosis-Karyorrhexis Index) neuroblastomas: A report from the Children's Oncology Group
Authors: Larry L. Wang, Risa Teshiba, Lejian He, Arlene Naranjo, Wendy B. London, Julie M. Gastier-Foster, Robert C. Seeger, Susan L. Cohn, John M. Maris, Julie R. Park, Michael D. Hogarty, Hiroyuki Shimada
Journal: Cancer Research (2014)

Abstract Background: In neuroblastoma (NB), Mitosis-Karyorrhexis Index (MKI; low-L, &amp;lt;100/5,000 cells; intermediate-I, 100-200/5,000 cells; high-H, &amp;gt;200/5,000 cells) is one of the histologic indicators for predicting a patient's clinical outcome. Event-Free Survival (EFS) and Overall Survival (OS) are significantly worse as MKI increases (p&amp;lt;0.0001): 3-year EFS for L-MKI (81.2+1.0%), I-MKI (68.6+1.8%), H-MKI (51.0+2.2%); and 3-year OS for L-MKI (92.0+0.7%), I-MKI (81.0+1.6%), H-MKI (64.4+2.1%). MYCN amplification (MYCN-A) is significantly associated with H-MKI, which indicates markedly increased mitotic (cellular proliferation) and karyorrhectic (cellular death) cells. However, about one-third of H-MKI tumors do not have MYCN-A. Study design: A total of 4,712 NB cases reviewed by the Children's Oncology Group (COG) Neuroblastoma Pathology Reference Laboratory (Children's Hospital Los Angeles) between 06/18/2001 and 06/06/2013 included 2,595 L-MKI (3% with MYCN-A), 1,197 I-MKI (16% with MYCN-A), and 920 H-MKI (70% with MYCN-A) tumors. In this study, immunohistochemical detection of MYCN and MYC (C-myc) protein was performed on 82 H-MKI tumors (53 with MYCN-A and 29 without MYCN-A). Results: 50/53 (94%) of H-MKI tumors having MYCN-A were positive for MYCN protein (including one case positive for both MYCN and MYC proteins), and only 3 cases were negative for both proteins immunohistochemically. Among the H-MKI tumors without MYCN-A, 16 cases (55%) showed positive staining for MYC protein, 6 cases (21%) were positive for MYCN protein, 2 cases (7%) were positive for both proteins, and 5 cases (17%) were negative for both proteins. Conclusions: MYCN-A and subsequent MYCN protein expression are considered as the starting point for leading NB tumors to H-MKI status. However, when MYCN is not amplified, high mitotic/karyorrhectic (M/K) activities in NB tumors are often associated with MYC protein expression. Even some MYCN non-amplified tumors can express MYCN protein, which is associated with H-MKI. There is still a small group of H-MKI tumors whose increased M/K activities are not related to MYCN/MYC protein expression. Citation Format: Larry L. Wang, Risa Teshiba, Lejian He, Arlene Naranjo, Wendy B. London, Julie M. Gastier-Foster, Robert C. Seeger, Susan L. Cohn, John M. Maris, Julie R. Park, Michael D. Hogarty, Hiroyuki Shimada. MYCN/MYC protein expression in high-MKI (Mitosis-Karyorrhexis Index) neuroblastomas: A report from the Children's Oncology Group. [abstract]. In: Proceedings of the AACR Special Conference on Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes; Nov 3-6, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;74(20 Suppl):Abstract nr B40.
808-5 Findings of intravascular ultrasound during acute stent thrombosis
Authors: Fernando Alfonso, Alfonso Suarez, Dominick J Angiolillo, Manel Sabate, Javier Escaned, Raul Moreno, Camino Bañuelos, Rosana Hernández-Antolín, Carlos Macaya
Journal: Journal of the American College of Cardiology (2004)
BENIGN GLYCOSURIA DUE TO DISTURBANCES IN THE BLOOD SUGAR REGULATING MECHANISM 1
Authors: Knud Faber
Journal: Journal of Clinical Investigation (1926)

Chr. Bohr, the Danish physiologist, always emphasized the im- portance of making an exact study of the adjustments exhibited by the organism to adapt the functions of the various organs to each other, and thereby to ensure the equilibrium of the organism necessary for maintaining a healthy, undisturbed life.Among these adjustments that of the blood sugar is one of the most interesting, both on account of its great significance in ensuring an undisturbed metabolism and also because quite minor disturbances in its regulation manifest themselves by abnormal phenomena in the individual.Besides the liver, acting as a reservoir between the intestine and the blood, one of the best known means possessed by the organism for the maintenance of a certain concentration of glucose in the blood is the sugar threshold.Since Claude Bernard's experiment in the middle of the last century, it has been known that glucose is not excreted in the urine until it exceeds a certain concentration.Ambard and after him Cushny thoroughly examined the "problem of thres- hold" in detail.After Bang had introduced the micro-method for the determination of blood sugar, Jacobsen (15) in our clinic found the value of the threshold in normal persons to be about 0.16 to 0.18 per cent of blood sugar.A number of investigators have subsequently confirmed this, in so far as they have demonstrated that this is the usual threshold value in normal individuals but on the other hand, higher or lower values are by no means rarely ob- served.Subsequently it was proved that the blood sugar level is not
D-type prostanoid receptor enhances the signaling of chemoattractant receptor–homologous molecule expressed on TH2 cells
Authors: Miriam Sedej, Ralf Schröder, Kathrin Bell, Wolfgang Platzer, Anela Vukoja, Evi Kostenis, Akos Heinemann, Maria Waldhoer
Journal: Journal of Allergy and Clinical Immunology (2011)
Immunoglobulin Deficiency and Idiotype Expression in Children Developing Haemophilus influenzae Type b Disease After Vaccination With Conjugate Vaccine
Authors: Sandra J. Holmes, Alexander H. Lucas, Michael T. Osterholm, James E. Froeschle, Dan M. Granoff
Journal: JAMA (1991)

--Haemophilus influenzae type b (Hib) conjugate vaccines are effective in preventing Haemophilus disease in most children. The reasons why the vaccination fails in some children are unknown. This study investigated host factors in children who developed the disease despite conjugate vaccination. DESIGN, PATIENTS, OUTCOME MEASURES:--A convenience sample of 23 patients in whom Hib disease developed 14 days or more after conjugate vaccination was investigated for the presence of subnormal serum immunoglobulin concentrations and anticapsular antibody responses to Hib disease. We also investigated expression of the Hib idiotype 1 (Hibld-1), a serological marker of a VKII chain that comprises a major portion of the normal variable region repertoire of the antibody response to Hib polysaccharide. The results were compared with those of 149 patients in whom the unconjugated Hib polysaccharide vaccine failed and of 90 unvaccinated patients who developed the disease.--Compared with children in whom the unconjugated polysaccharide vaccination failed, the relative risk of a subnormal serum concentration of IgM, IgA, IgG, and/or IgG2 in the children in whom the conjugate vaccination failed was 4.9 (95% confidence interval [CI], 1.8 to 14; P less than .003) and of IgG2 was 22 (95% CI, 3.5 to 146; P less than .001). With the exception of the children with subnormal serum immunoglobulin concentrations, most of the children with conjugate vaccination failure showed normal or high anticapsular antibody responses to the disease, whereas the children with polysaccharide vaccination failure showed impaired responses. The Hibld-1 was expressed by the majority of the children in both vaccination failure groups and of the unvaccinated patients.--In most patients, vaccination failure is not attributable to lack of expression of the variable region gene encoding Hibld-1. However, children in whom conjugate vaccination has failed frequently have subnormal serum immunoglobulin concentrations and should be evaluated for immunodeficiency.
Abstract 1578: Endogenous Adenosine Protects the Heart from Severe Systolic Overload Induced Ventricular Hypertrophy and Congestive Heart Failure
Authors: Xin Xu, John Fassett, Xinli Hu, Guangshuo Zhu, Jurgen Schnermann, Robert J Bache, Yingjie Chen
Journal: Circulation (2006)

Adenosine regulates myocardial blood flow and protects the heart from acute ischemia-reperfusion induced damage. However, the effect of endogenous adenosine on chronic systolic overload induced left ventricular hypertrophy (LVH) and congestive heart failure (CHF) is unknown. CD73 uses AMP as substrate to generate adenosine, and CD73-deficiency attenuates extracellular adenosine production. To determine the effect of endogenous adenosine on LVH and CHF, the degree of LV hypertrophy, dilation and dysfunction in response to severe transverse aortic constriction (TAC) was determined in CD73-deficient (CD73-KO) mice and their wild type littermates. CD73-KO mice develop and grow normally without obvious cardiovascular defects or dysfunction. Although there was no difference in heart weight, lung weight, or LV function between CD73-KO mice and wild type littermates (WTL) under unstressed conditions, CD73-KO mice demonstrated more severe myocardial hypertrophy, LV dilation and LV dysfunction in response to systol...
Overexpression of Transforming Growth Factor-β Is Associated With Increased Hyaluronan Content and Impairment of Repair in Marfan Syndrome Aortic Aneurysm
Authors: Maria Nataatmadja, Jennifer West, Malcolm West
Journal: Circulation (2006)

Marfan syndrome (MFS), a condition caused by fibrillin-1 gene mutation is associated with aortic aneurysm that shows elastic lamellae disruption, accumulation of glycosaminoglycans, and vascular smooth muscle cell (VSMC) apoptosis with minimal inflammatory response. We examined aneurysm tissue and cultured cells for expression of transforming growth factor-beta1 to -beta3 (TGFbeta1 to 3), hyaluronan content, apoptosis, markers of cell migration, and infiltration of vascular progenitor cells (CD34).MFS aortic aneurysm (6 males, 5 females; age 8 to 78 years) and normal aorta (5 males, 3 females; age 22 to 56 years) were used. Immunohistochemistry showed increased expression of TGFbeta1 to 3, hyaluronan, and CD34-positive microcapillaries in MFS aneurysm compared with control. There was increased expression of TGFbeta1 to 3 and hyaluronan in MFS cultured VSMCs, adventitial fibroblasts (AF), and skin fibroblasts (SF). Apoptosis was increased in MFS (VSMC: mean cell loss in MFS 29%, n of subjects=5, versus control 8%, n=3, P<0.05; AF: 28%, n=5 versus 7%, n=5, P<0.05; SF: 29%, n=3 versus 4%, n=3, not significant). In MFS, there was a 2-fold increase in adventitial microcapillaries containing CD34-positive cells compared with control tissue. Scratch wound assay showed absence of CD44, MT1-MMP, and beta-3 integrin at the leading edge of migration in MFS indicating altered directional migration. Western blot showed increased expression of TGFbeta1 to 3 in MFS but no change in expression of CD44, MT1-MMP, or beta-3 integrin compared with controls.There was overexpression of TGF-beta in MFS associated with altered hyaluronan synthesis, increased apoptosis, impaired progenitor cell recruitment, and abnormal directional migration. These factors limit tissue repair and are likely to contribute to aneurysm development.
INTERMITTENT CHEMOTHERAPY IN THE TREATMENT OF TUBERCULOSIS CUTIS.
Authors: V. S. RAJAN, Y. S. GOH
Journal: British Journal of Dermatology (1972)

Journal Article INTERMITTENT CHEMOTHERAPY IN THE TREATMENT OF TUBERCULOSIS CUTIS: A PRELIMINARY REPORT Get access V. S. RAJAN, V. S. RAJAN Middle Road Hospital, Singapore 7 Search for other works by this author on: Oxford Academic Google Scholar Y. S. GOH Y. S. GOH Middle Road Hospital, Singapore 7 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 3, 1 September 1972, Pages 270–273, https://doi.org/10.1111/j.1365-2133.1972.tb00317.x Published: 01 September 1972 Article history Accepted: 14 March 1972 Published: 01 September 1972