tbuckley/cabot-search huggingface dataset:
Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts.
Authors: R B Mannon, B L Kotzin, C Nataraj, K Ferri, E Roper, R J Kurlander, T M Coffman
Journal: Journal of Clinical Investigation (1998)

Allospecific CD8(+) T lymphocytes are an important component of the cellular response in allograft rejection. These cells recognize and engage MHC class I antigens, leading to allospecific cytolytic responses and graft rejection. In mouse kidney allografts that survive to 3 wk after transplantation, we noted that the majority of CD8(+) cells do not express surface alpha/beta T cell receptor alpha/beta(TCR), gamma/deltaTCR, or CD3. However, these CD8(+)TCR- cells did express surface markers characteristic of T cells, including Thy1.2, CD2, and CD5. In addition, the CD8(+)TCR- cells expressed mRNA for TCR Vbeta gene families, and nearly half stained positive for cytoplasmic Vbeta8 protein, suggesting that they are T cells that have downregulated alpha/betaTCR protein expression from their cell surfaces. When these surface TCR- cells were isolated from kidney allografts by flow cytometry and cultured in the presence of either allogeneic or syngeneic stimulators, nearly 100% of cells reacquired normal levels of alpha/betaTCR expression with disproportionate usage of Vbeta8 chains. After recovery of their surface TCR expression, the CD8(+)TCR- population demonstrated strong alloreactivity in culture. These results suggest that the substantial number of CD8(+)TCR- cells found in long-term surviving mouse kidney allografts are alpha/beta-T cells that have downregulated their cell surface expression of TCR. While in other systems this phenotype may identify cells that have engaged antigen, our results indicate that loss of TCR expression by CD8(+) kidney graft-infiltrating cells may not depend on antigen engagement and that elements in the microenvironment of the kidney graft play a key role in this process. Factors that modulate expression of TCR by graft-infiltrating lymphocytes may have an important role in regulating rejection responses.
The Clinical Value of Lymphatic Micrometastases in Patients with Non-small Cell Lung Cancer
Authors: Ad F. Verhagen, Johan Bulten, Hebste Shirango, Frederik B.J.M. Thunnissen, Miep A. van der Drift, Wouter van der Bruggen, Vivianne C.G. Tjan-Heijnen, Henry A. van Swieten
Journal: Journal of Thoracic Oncology (2010)
Familial hypertrophic cardiomyopathy. Microsatellite haplotyping and identification of a hot spot for mutations in the beta-myosin heavy chain gene.
Authors: E Dausse, M Komajda, L Fetler, O Dubourg, C Dufour, L Carrier, C Wisnewsky, J Bercovici, C Hengstenberg, S al-Mahdawi
Journal: Journal of Clinical Investigation (1993)

Familial hypertrophic cardiomyopathy (FHC) is a clinically and genetically heterogeneous disease. The first identified disease gene, located on chromosome 14q11-q12, encodes the beta-myosin heavy chain. We have performed linkage analysis of two French FHC pedigrees, 720 and 730, with two microsatellite markers located in the beta-myosin heavy chain gene (MYO I and MYO II) and with four highly informative markers, recently mapped to chromosome 14q11-q12. Significant linkage was found with MYO I and MYO II in pedigree 720, but results were not conclusive for pedigree 730. Haplotype analysis of the six markers allowed identification of affected individuals and of some unaffected subjects carrying the disease gene. Two novel missense mutations were identified in exon 13 by direct sequencing, 403Arg-->Leu and 403Arg-->Trp in families 720 and 730, respectively. The 403Arg-->Leu mutation was associated with incomplete penetrance, a high incidence of sudden deaths and severe cardiac events, whereas the consequences of the 403Arg-->Trp mutation appeared less severe. Haplotyping of polymorphic markers in close linkage to the beta-myosin heavy chain gene can, thus, provide rapid analysis of non informative pedigrees and rapid detection of carrier status. Our results also indicate that codon 403 of the beta-myosin heavy chain gene is a hot spot for mutations causing FHC.
Ham Radio Gives Physicians Long Reach
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene Transfer of Extracellular Superoxide Dismutase Ameliorates Pulmonary Hypertension in Rats
Authors: Fumihiko Kamezaki, Hiromi Tasaki, Kazuhito Yamashita, Masato Tsutsui, Shinichiro Koide, Sei Nakata, Akihide Tanimoto, Masahiro Okazaki, Yasuyuki Sasaguri, Tetsuo Adachi, Yutaka Otsuji
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Rationale: Pulmonary hypertension (PH) is a life-threatening disease, characterized by vascular remodeling and vasoconstriction. Evidence suggests that oxidative stress may contribute to the pathogenesis and/or development of PH.Objectives: In the present study, we examined whether intratracheal gene transfer of human extracellular superoxide dismutase (EC-SOD) could ameliorate monocrotaline (MCT)–induced PH in rats.Methods: MCT-injected rats were intratracheally administered vehicle (MCT group) or an adenovirus encoding β-galactosidase (Adβgal group) or human EC-SOD (AdEC-SOD group).Measurements and Main Results: After intratracheal gene transfer, EC-SOD was successfully expressed in lung tissue, bronchoalveolar lavage fluid, and plasma. Twenty-eight days after MCT injection, right ventricular systolic pressure and the weight ratio of the right ventricle to the left ventricle plus septum were significantly lower in the AdEC-SOD group (42.50 ± 1.46 mm Hg and 0.453 ± 0.029, respectively) than in the MCT group (59.89 ± 1.61 mm Hg and 0.636 ± 0.022, respectively) or the Adβgal group (61.50 ± 2.61 mm Hg and 0.653 ± 0.038, respectively). Moreover, vascular remodeling and proliferation of vascular smooth muscle cells in pulmonary arteries were markedly suppressed in the AdEC-SOD group. Importantly, 8-isoprostane in lung tissue was also significantly reduced in the AdEC-SOD group.Conclusions: EC-SOD overexpression to the lung ameliorated MCT-induced PH in rats. We suggest that EC-SOD may act as an antioxidant in PH and that increased oxidative stress may be important in the pathogenesis of MCT-induced PH.
SPECT and Subtraction Imaging of an Ectopic Parathyroid Adenoma
Authors: LEON S. SERCHUK, MARIA B. TOMAS, MAHENDRA PATEL, CHRISTOPHER J. PALESTRO
Journal: Clinical Nuclear Medicine (1997)

Primary hyperparathyroidism is a disease best managed surgically; resection of the lesion(s) is curative. Although the routine use of localizing procedures is controversial before surgery, it is generally agreed that these techniques are useful in cases of reexploration. The authors have recently studied a patient with long-standing hyperparathyroidism, in whom initial surgery was unsuccessful. Although planar imaging with Tc-99m sestamibi is usually sufficient for identification and localization of the lesion, both SPECT and subtraction imaging provided additional information that contributed to the success of the subsequent surgery. Single-proton emission computed tomography provided critical information about the position of the ectopic parathyroid adenoma in relation to the right submandibular salivary gland, whereas subtraction imaging confirmed that the focus was indeed a parathyroid lesion, and not merely an anatomic variant of a normal salivary gland.
The good of small things
Authors: M. J Marret
Journal: BMJ (2003)

I first met “Salmah” when she was about nine. She had cerebral palsy and had spent her life confined to her bed or wheelchair, relying on her family for her every need. To some people it might seem a useless or meaningless existence—always needing someone there to turn, change, or feed her. Yet these were acts of love that her family carried out devotedly. Most of the time she would show no sign that she saw or heard much. Quite often what I elicited were grimaces or protesting moans as I tried to move her stiff limbs while examining her. Once in a while she would surprise us with a broad grin or a near chuckle, as if sharing a good joke.

As time went on I felt increasingly inadequate, with little to offer except regular prescriptions of anticonvulsants or suggestions to improve her seating or her constipation. She grew larger, making it more difficult for her family to move her. Transportation became a complicated logistical exercise.

> Everything we do for our patients has …
Paget??s Disease of the Skull
Authors: CHRISTOPHER J. PALESTRO, AMARILIS VEGA, CHUN K. KIM, STANLEY J. GOLDSMITH
Journal: Clinical Nuclear Medicine (1990)

A 27-year-old woman on steroid therapy for systemic lupus erythematosus had shortness of breath and a clear chest radiograph. The patient underwent scintigraphy 48 hours after the injection of 5 mCi of Ga-67 citrate because of the possibility of opportunistic pulmonary infection. Although the lung fields were scintigraphically normal, intense, homogeneously increased tracer accumulation was noted throughout a mildly enlarged skull. The differential diagnosis of this scintigraphic pattern included fibrous dysplasia and Paget's disease; skull radiographs subsequently obtained were consistent with Paget's disease.
Recommendations of the 2006 Human Variome Project meeting
Authors: Cotton Rg, Appelbe W, Auerbach Ad, Becker K, Bodmer W, Boone Dj, Boulyjenkov, Brahmachari S, Brody L, Brookes A, Brown Af, Byers P, Cantu Jm, Cassiman Jj, Claustres M, Concannon P, den Dunnen Jt, Flicek P, Gibbs R, Hall J, Hasler J, Katz M, Kwok Py, Laradi S, Lindblom A, Maglott D, Marsh S, Masimirembwa Cm, Minoshima S, de Ramirez Am, Pagon R, Ramesar R, Ravine D, Richards S, Rimoin D, Ring Hz, Scriver Cr, Sherry S, Shimizu N, Stein L, Tadmouri Go, Taylor G, Watson M
Journal: Nature Genetics (2007)
Robust Functional Vascular Network Formation In Vivo by Cooperation of Adipose Progenitor and Endothelial Cells
Authors: Dmitry O. Traktuev, Daniel N. Prater, Stephanie Merfeld-Clauss, Aravind Raj Sanjeevaiah, M. Reza Saadatzadeh, Michael Murphy, Brian H. Johnstone, David A. Ingram, Keith L. March
Journal: Circulation Research (2009)

Rapid induction and maintenance of blood flow through new vascular networks is essential for successfully treating ischemic tissues and maintaining function of engineered neo-organs. We have previously shown that human endothelial progenitor cells (EPCs) form functioning vessels in mice, but these are limited in number and persistence; and also that human adipose stromal cells (ASCs) are multipotent cells with pericytic properties which can stabilize vascular assembly in vitro. In this study, we tested whether ASCs would cooperate with EPCs to coassemble vessels in in vivo implants. Collagen implants containing EPCs, ASCs, or a 4:1 mixture of both were placed subcutaneously into NOD/SCID mice. After a range of time periods, constructs were explanted and evaluated with regard to vascular network assembly and cell fate; and heterotypic cell interactions were explored by targeted molecular perturbations. The density and complexity of vascular networks formed by the synergistic dual-cell system was many-fold higher than found in implants containing either ASCs or EPCs alone. Coimplantation of ASCs and EPCs with either pancreatic islets or adipocytes produced neoorgans populated by these parenchymal cells, as well as by chimeric human vessels conducting flow. This study is the first to demonstrate prompt and consistent assembly of a vascular network by human ASCs and endothelial cells and vascularization by these cells of parenchymal cells in implants. Mixture of these 2 readily available, nontransformed human cell types provides a practical approach to tissue engineering, therapeutic revascularization, and in vivo studies of human vasculogenesis.
Antibiotics and Growth
Authors: Arthur J. Tronstein
Journal: JAMA (1961)

<h3>To the Editor:—</h3> InThe Journal, Jan. 21, page 266, "M.D., Missouri," asked about the methods by which antibiotics stimulate growth in young animals and also if these effects have been known in human usage. The reply by John R. Lewis, Ph.D., is incomplete. While the exact mode by which antibiotics stimulate growth in young animals is not clearly understood, there is evidence that this action is not entirely a result of changes in bacterial flora or of the bactericidal and bacteria-static actions of the antibiotics. As pointed out in my paper on the use of antibiotics for the treatment of acne (<i>Ohio State Med J</i>, April, 1959), the amounts used for supplemental feeding to animals and poultry are minute as compared to the usual dosages considered necessary for therapy in human or animal infectious diseases, and most likely would not be effective in active disease. The amounts used in
Discordant Uptake of Dual Pharmaceuticals on Brain SPECT in Meningioma
Authors: NOLAN K. SAKOW, CAROLE A. KIPHART
Journal: Clinical Nuclear Medicine (1996)

It has been well described that Tc-99m sestamibi has an important and expanding role in nuclear oncology. It has, for the most part in oncology, replaced Tl-201, which has a longer history of use but is less desirable because of its smaller dose and imaging characteristics. Sestamibi is also known to be avid for many benign and malignant neoplasms (i.e., breast, lung, sarcoma, lymphoma, thyroid and parathyroid neoplasms). The proposed mechanism of uptake is probably related to blood flow, mitochondrial content, and negative plasma membrane potential. This article describes a meningioma patient who underwent dual radiopharmaceutical imaging with brain SPECT scanning.
Circumcision Is a Religious/Cultural Procedure, Not a Medical Procedure
Authors: J. Steven Svoboda
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
ENZYMES AND ANTI-ENZYMES OF INFLAMMATORY EXUDATES
Authors: Eugene L. Opie
Journal: The Journal of Experimental Medicine (1905)

The serum of an inflammatory exudate has the power of inhibiting the action of proteolytic ferments contained in the leucocytes. This anti-enzymotic power is possessed by the blood serum from which it doubtless passes into the exudate. In the later stages of inflammation there is some diminution of this anti-enzymotic action. The anti-body contained in the serum is destroyed by a temperature of 75 degrees C. The proteolytic ferments of the leucocytes act both in an acid and in an alkaline medium but are most efficient in the latter. The anti-enzymotic action of the serum is favored by an alkaline reaction, but is completely lost in an acid medium.
Accelerated Atherosclerosis in Autoimmune Rheumatic Diseases
Authors: Yehuda Shoenfeld, Roberto Gerli, Andrea Doria, Eiji Matsuura, Marco Matucci Cerinic, Nicoletta Ronda, Luis J. Jara, Mahmud Abu-Shakra, Pier Luigi Meroni, Yaniv Sherer
Journal: Circulation (2005)
F-18 FDG PET Imaging of Urinary Bladder Oat Cell Carcinoma With Widespread Osseous Metastases
Authors: Andrei Iagaru, Sherief Gamie, George Segall
Journal: Clinical Nuclear Medicine (2006)

We present coronal views of serial whole-body F-18 FDG PET scans obtained from a 71-year-old man with recently diagnosed oat cell carcinoma (OCC) of the bladder as well as pathology slides from bladder biopsy. Transmission images were first acquired and were followed by emission images at 1 hour after intravenous administration of 14.9 mCi of the radiopharmaceutical. F-18 FDG PET revealed widespread osseous metastatic disease, upstaging the patient and changing the management of disease. Repeat F-18 FDG PET after 2 and 6 cycles of cisplatin and etoposide chemotherapy showed reduction and resolution of osseous metastases. The tumor had a Ki-67 proliferation fraction of 90%, TTF1 was focally positive; chromogranin, PSA, and PAP were negative. Immunohistochemical stains for keratin and synaptophysin were positive. These findings are typical for OCC.
Possible hepatotoxicity of zimelidine.
Authors: G K Simpson, N M Davidson
Journal: BMJ (1983)

Possible hepatotoxicity of zimelidineZimelidine (Zelmid, Astra), which acts on the 5-hydroxytryptamine neuronal system, is a recent preparation for treating depression.Cholinergic and cardiovascular side effects are reportedly fewer than with established antidepressent drugs.1 2 We report on a patient who developed hepatocellular jaundice and fever during treatment with zimelidine and whose symptoms recurred on inadvertent rechallenge with the drug. Case reportA 47 year old insulin dependent diabetic consulted her general prac- titioner eight times over two months with varied physical symptoms including premenstrual tension, nausea, dizziness, anorexia, weight loss, and paraes- thesia.She was often weepy and lacked confidence.She was treated un- successfully with lorazepam, ketazolam, betahistine, metoclopramide, amitriptyline, and cyclizine and was then given zimelidine 100 mg twice daily and lorazepam 1 mg as required.Nine days later she was admitted to this hospital with increasing nausea, vomiting, and lassitude.She did not have headache.She was febrile (temperature 385'C) and jaundiced but did not have hepatomegaly.Serum
BROMIDE ERUPTION ON HARD PALATE
Authors: Frederick H. Dillingham
Journal: JAMA (1928)

The cutaneous eruption which results from the ingestion of the salts of bromide and iodide is by no means rare. However, an eruption produced by the halogen group on the mucosa is unusually rare. So far as we can ascertain, there are only two references pertaining to this subject. In 1904, Dr. Lotta Wright Myers<sup>1</sup>reported the case of an infant, aged 6 months, who developed a very unusual bromide eruption after the ingestion of a small quantity of potassium bromide. The interesting feature in this case is the fact that the child developed a bromide lesion on the tongue. Dr. Myers stated that while a few cases simulating hers, from the cutaneous point of view, have been reported, there had not been any instances up to that time of a bromide eruption occurring on the mucous membrane from one of the bromide salts. Dr. Arthur Hall, cited by Dr. Lotta
Effect of nicotine chewing gum as an adjunct to general practitioners' advice against smoking
Authors: A. Cartwright
Journal: BMJ (1984)

A double-blind, crossover study was carried out to investigate the effect of nedocromil sodium on the dual asthmatic response to exercise challenge. Nineteen patients with a late response to bicycle exercise were randomly treated on two study days with 4 mg nedocromil sodium or a matched placebo aerosol, 30 min before commencing exercise. Peak flow was measured before exercise, at intervals up to 60 min after exercise, then hourly for up to 13 h. In 12 of the 19 patients an early reaction to exercise occurred. In 8 of these 12 patients the early reaction could be inhibited by nedocromil sodium (p less than 0.01) although in half of these patients placebo was also shown to be protective. In the case of the late reaction after exercise challenge, 4-13 h after exercise challenge, nine patients were clearly protected by pretreatment with nedocromil sodium (p less than 0.01) when the fall in peak expiratory flow rate was related to the pre-exercise baseline, four patients showed an equal protective effect of placebo and nedocromil sodium, whilst the others were not protected. When the late asthmatic response (fall in peak expiratory flow rate) after exercise challenge was related to control diurnal peak flow values, the number of responses was reduced; the protective effect of nedocromil sodium remained.
Systemic Weber-Christian disease: a case report with lipoprotein profile and immunological evaluation
Authors: P.J. CICLITIRA, D.G.D. WIGHT, A.P. DICK
Journal: British Journal of Dermatology (1980)

A case of fatal systemic Weber‐Christian disease is described. In vitro immunological function and lipoprotein measurements are presented with a subsequent discussion on the possible aetiology of the condition.
Gut microbial communities modulating brain development and function
Authors: Maha Al-Asmakh, Farhana Anuar, Fahad Zadjali, Joseph Rafter, Sven Pettersson
Journal: Gut Microbes (2012)

Mammalian brain development is initiated in utero and internal and external environmental signals can affect this process all the way until adulthood. Recent observations suggest that one such external cue is the indigenous microbiota which has been shown to affect developmental programming of the brain. This may have consequences for brain maturation and function that impact on cognitive functions later in life. This review discusses these recent findings from a developmental perspective.
Glimepiride Treatment and IGF-I in Adolescents With Type 1 Diabetes
Authors: Stefan A. Wudy, Josef Högel, Barbara Dollinger, Primus Mullis, Eberhard Heinze
Journal: Diabetes Care (2003)

Serum IGF-I is reduced in adolescents with type 1 diabetes, and injections of IGF-I improve glycemic control (1). The fact that sulfonylureas can increase IGF-I directly and independent of insulin has not been included in standard literature (2). The first observation of a stimulatory effect on serum IGF-I was made in hypophysectomized rats (3). In in vitro experiments, glibenclamide stimulated growth of human chondrocytes via IGF-I and independent of insulin (4). Glibenclamide and glimepiride had dose-dependent stimulatory effects on IGF-I transcription and production in human liver cells (HuH7) (5).

We recruited 40 pubertal patients with type 1 diabetes of a duration of >1 year (negative for C-peptide) at Ulm ( n = 20) and Bern ( n = 20). …
Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction
Authors: Myung-Shin Jeon, Alex Atfield, K. Venuprasad, Connie Krawczyk, Renu Sarao, Chris Elly, Chun Yang, Sudha Arya, Kurt Bachmaier, Leon Su, Dennis Bouchard, Russel Jones, Mathew Gronski, Pamela Ohashi, Teiji Wada, Debra Bloom, C.Garrison Fathman, Yun-Cai Liu, Josef M. Penninger
Journal: Immunity (2004)