tbuckley/cabot-search huggingface dataset:
Hypertrophy induced alteration of action potential and effects of the inhibition of angiotensin converting enzyme by perindopril in infarcted rat hearts
Authors: C THOLLON, P KREHER, V CHARLON, A ROSSI
Journal: Cardiovascular Research (1989)

Journal Article Hypertrophy induced alteration of action potential and effects of the inhibition of angiotensin converting enzyme by perindopril in infarcted rat hearts Get access C THOLLON, C THOLLON From the Laboratoire de Physiologie cellulaire cardiaque, Université Joseph Fourier, Grenoble, France Address for correspondence and reprints: Dr C Thollon, Laboratoire de Physiologie cellulaire cardiaque, URACNRS No 632, Université Joseph Fourier, Grenoble 1, BP53X-38041 Grenoble Cedex, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar P KREHER, P KREHER From the Laboratoire de Physiologie cellulaire cardiaque, Université Joseph Fourier, Grenoble, France Search for other works by this author on: Oxford Academic PubMed Google Scholar V CHARLON, V CHARLON From the Laboratoire de Physiologie cellulaire cardiaque, Université Joseph Fourier, Grenoble, France Search for other works by this author on: Oxford Academic PubMed Google Scholar A ROSSI A ROSSI From the Laboratoire de Physiologie cellulaire cardiaque, Université Joseph Fourier, Grenoble, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 23, Issue 3, March 1989, Pages 224–230, https://doi.org/10.1093/cvr/23.3.224 Published: 01 March 1989 Article history Accepted: 31 October 1988 Published: 01 March 1989
Ethylene glycol monomethyl ether (EGME) and propylene glycol monomethyl ether (PGME): inhalation fertility and teratogenicity studies in rats, mice and rabbits.
Authors: T R Hanley, J T Young, J A John, K S Rao
Journal: Environmental Health Perspectives (1984)

A combined dominant lethal-fertility study was conducted in which male and female Sprague-Dawley (CD) rats were exposed to 0, 30, 100 or 300 ppm of ethylene glycol monomethyl ether (EGME) vapor for 6 hr/day, 5 days/week for 13 weeks and then mated to untreated counterparts. Among males, fertility was completely suppressed after exposure to 300 ppm. A partial restoration of reproductive function was evident following 13 weeks of recovery. No treatment-related reproductive effects were observed among males exposed subchronically to 100 ppm, or among females exposed to 300 ppm or below of EGME. Studies to assess the effects of inhaled EGME on embryonal and fetal development were also conducted in Fischer 344 rats, CF-1 mice, and New Zealand White rabbits. Rats and rabbits were exposed to concentrations of 0, 3, 10 or 50 ppm for 6 hr/day on days 6-15 or 6-18 of gestation, respectively. Exposure of rabbits to 50 ppm resulted in significant teratologic effects, an increased resorption rate, and decreased fetal body weight. Slight fetotoxicity in the form of skeletal variations were observed among rats exposed to 50 ppm. Exposure of pregnant mice to 0, 10, or 50 ppm for 6 hr/day on days 6-15 of gestation resulted in slight fetotoxicity at 50 ppm. No significant treatment-related effects were observed at 10 ppm of EGME or below in any of the species tested. Separate groups of pregnant rats and rabbits were exposed to 0, 500, 1500 or 3000 ppm of propylene glycol monomethyl ether (PGME) during organogenesis.(ABSTRACT TRUNCATED AT 250 WORDS)
Human Coxsackie-Adenovirus Receptor Is Colocalized With Integrins α <sub>v</sub> β <sub>3</sub> and α <sub>v</sub> β <sub>5</sub> on the Cardiomyocyte Sarcolemma and Upregulated in Dilated Cardiomyopathy
Authors: Michel Noutsias, Henry Fechner, Henriëtte de Jonge, Xiaomin Wang, Dick Dekkers, A.B. Houtsmuller, Matthias Pauschinger, Jeffrey Bergelson, Rahat Warraich, Magdi Yacoub, Roland Hetzer, Jos Lamers, Heinz-Peter Schultheiss, Wolfgang Poller
Journal: Circulation (2001)

Background The coxsackievirus and adenovirus receptor (CAR) was identified as a common cellular receptor for both viruses, but its biological and pathogenic relevance is uncertain. Knowledge of CAR localization in the human cardiovascular system is limited but important with respect to CAR-dependent viral infections and gene transfer using CAR-dependent viral vectors. Methods and Results Explanted failing hearts from 13 patients (8 with dilated cardiomyopathy [DCM] and 5 with other heart diseases [non-DCM]) and normal donor hearts (n=7) were investigated for the expression levels and subcellular localization of CAR and the adenovirus coreceptors α v β 3 and α v β 5 integrins. CAR immunoreactivity was very low in normal and non-DCM hearts, whereas strong CAR signals occurred at the intercalated discs and sarcolemma in 5 of the 8 DCM hearts (62.5%); these strong signals colocalized with both integrins. In all hearts, CAR was detectable in subendothelial layers of the vessel wall, but not on the luminal endothelial surface, and on interstitial cells. Human CAR (hCAR) expressed in rat cardiomyocytes was targeted to cell-cell contacts, which resembled CAR localization in DCM hearts and resulted in 15-fold increased adenovirus uptake. Conclusions Low hCAR abundance may render normal human myocardium resistant to CAR-dependent viruses, whereas re-expression of hCAR, such as that observed in DCM, may be a key determinant of cardiac susceptibility to viral infections. Asymmetric expression of hCAR in the vessel wall may be an important determinant of adenovirus tropism in humans. hCAR subcellular localization in human myocardium and hCAR targeting to cell-cell contacts in cardiomyocyte cultures suggest that hCAR may play a role in cell-cell contact formation.
THE CATHOLIC CHURCH AND THE LOURDES CURES
Authors: F. A. Gasquet
Journal: BMJ (1910)

THE LOURDES CURES.r X TD BAoJx 465 the end of a week we had a long talk, and that night I determined to make more effort.... Then about walking, I was not told at all what I was to do, only I knew he thought I should do a little more each day. . . .I got the strength during
Ratio of Serum Levels of AGEs to Soluble Form of RAGE Is a Predictor of Endothelial Function
Authors: Masato Kajikawa, Ayumu Nakashima, Noritaka Fujimura, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi Iwamoto, Takeshi Matsumoto, Nozomu Oda, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Yoshiki Aibara, Kensuke Noma, Masayoshi Takeuchi, Takanori Matsui, Sho-ichi Yamagishi, Yukihito Higashi
Journal: Diabetes Care (2014)

OBJECTIVE Advanced glycation end products (AGEs) and their specific receptor, the receptor for AGEs (RAGE), play an important role in atherosclerosis. Recently, a soluble form of RAGE (sRAGE) has been identified in human serum. However, the role of sRAGE in cardiovascular disease is still controversial. There is no information on the association between simultaneous measurements of AGEs and sRAGE and vascular function. In this study, we evaluated the associations between serum levels of AGEs and sRAGE, ratio of AGEs to sRAGE, and vascular function. RESEARCH DESIGN AND METHODS We measured serum levels of AGEs and sRAGE and assessed vascular function by measurement of flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation in 110 subjects who underwent health examinations. Multivariate regression analyses were performed to identify factors associated with vascular function. RESULTS Univariate regression analysis revealed that FMD correlated with age, BMI, systolic blood pressure, diastolic blood pressure, heart rate, triglycerides, HDL cholesterol, glucose, smoking pack-years, nitroglycerine-induced vasodilation, serum levels of AGEs and sRAGE, and ratio of AGEs to sRAGE. Multivariate analysis revealed that the ratio of AGEs to sRAGE remained an independent predictor of FMD, while serum level of AGEs alone or sRAGE alone was not associated with FMD. CONCLUSIONS These findings suggest that sRAGE may have a counterregulatory mechanism that is activated to counteract the vasotoxic effect of the AGE–RAGE axis. The ratio of AGEs to sRAGE may be a new chemical biomarker of endothelial function.
Sermons in Stones —
Authors: Henry Jackson
Journal: New England Journal of Medicine (1956)

NOT very long ago there was a little boy of thirteen summers in a small New England town. He looked to be about nine or ten. Though bright as a button, he was very short and at the age of thirteen he showed not the slightest evidence, either physically or emotionally, of sexual maturity. A local doctor full of whimsey and the latest "scientific" ideas, filled him with expensive medicines, no one of which could possibly make him grow. One of them could, quite easily, do considerable harm. No adequate family history had been taken in spite of the fact . . .
William Carlos Williams
Authors: Robert Coles
Journal: JAMA (1981)

"I'M a doctor all day and into the night; I write on the run, or when it's plenty dark, before going to bed." That autobiographical fragment was sent to an inquiring Harvard undergraduate who wanted to make a clearer distinction between a particular person's vocation and avocation than the student was disposed to allow. I happened to be the lucky recipient of the message. I was writing a major paper on the American poet (and novelist, and writer of short stories, and essayist, and playwright) William Carlos Williams and felt emboldened to ask a few questions of him. He was more than forthright; he answered in strong, wry, bemused language. And he offered a bonus: If I ever wanted to accompany him on his medical rounds, I would be welcome. I quickly accepted and soon enough found myself utterly captivated by this brilliant, energetic, many-sided man from Rutherford, NJ, who
On the Provisions of the New Medical Bill
Authors: J. Brown
Journal: BMJ (1844)

Dr. Fletcher presented to the Society two kidneys in the third stage of granular disease, which had been taken from a female patient, aged 54, whom he had attended with Mr. Harman.He first visited her April 18, 1844, when she was delirious, and suffered from many symptoms of hysteria; pulse 70, feeble; head hot; right arm somewhat torpid in its motions.She said she could not move it, though she had been observed to do so.With the exception of the heat of the bead no symptom of disease of the brain presented itself.The organs of the chest presented no signs of disease upon physical examination; nor did any of the organs of the abdomen.No cedema of the face or extremities.The urine was described as scanty, but none could be obtained; a small quantity was after- wards obtained, when it was found to be strongly coagulable, that is to say, the precipitate, after allow- ing tie urine to stand twenty-four hours after heating, occupied half the volume of the fluid.The case was iregarded as a pure case of albuminuria.Six leeches |were ordered to be applied to the head, and a third of a grain of elaterium, with two grains of calomel, and five of extract of hyosciamus, every third day.April 21.The leeches were said to produce a great deal of debility.The elaterium acted freely upon the
Asthmatic Deaths in Children
Authors: J. J. Robbins
Journal: JAMA (1966)

<h3>To the Editor:—</h3> There is an often-quoted opinion concerning the treatment of bronchial asthma, repeated by Kessler and Geller-Bernstein (<b>196</b>: 458, 1966), that asthmatic deaths in children have risen in recent years because of wide-spread use of steroids. Although, as these Israeli physicians state, hypoadrenalism is a distinct possibility, the evidence is against this explanation for deaths in asthma. The death-rate increase antedates the steroid era. Mustachi in an epidemiological study in 1962 states that there were 6,000 deaths from asthma in 1956 in the United States. In not a single postmortem study of asthma deaths has significant adrenal atrophy been demonstrated. Certainly none of adrenal hemorrhage has come to my attention. In my own experience with over 1,500 asthma patients in the last ten years, although ketosteroid levels have generally been low in steroid-treated patients, no mortality has been encountered. The consistent finding at post-mortem, as in Richards' cases,
A randomised controlled trial of feedback to general practitioners of their prophylactic aspirin prescribing
Authors: P. McCartney, W. Macdowall, M. Thorogood
Journal: BMJ (1997)

Objective: To estimate the miscarriage rate in a cohort of pregnant women and the final outcome of pregnancy.Design: Two year prospective community study.Setting: Women registered with four semirural practices at one health centre.Subjects: 626 pregnant women from a population 21 448, 5140 of whom were women aged 15-44 years. Main outcome measures: Vaginal bleeding and outcome of pregnancy.Results: 76 of the 89 women with an unwanted pregnancy requested a termination.In the 550 ongoing pregnancies bleeding occurred before the 20th week in 117 (21%), and 67 (12%) ended in miscarriage.The risk of miscarriage was not significantly increased after a miscarriage in the previous pregnancy (11 (15%) women had miscarriage v 55 (12%) women who had not had miscarriage) who had previously had a live birth).Of the 117 women with bleeding, 64 were not admitted to hospital by the general practitioner; 42 of these women had an ultrasound examination at the health centre and 19 subsequently miscarried at home.In hospital 41 of 46 women who miscarried had evacuation of the uterus.Conclusions: Bleeding occurred in one fifth of recognised pregnancies before the 20th week and over half of these miscarried.Treatment of women with miscarriage at home means current statistics on miscarriage in Britain are missing many cases.
Quantitative assessment of the immediate results of coronary angioplasty by myocardial contrast echocardiography
Authors: Shimon A. Reisner, Ling S. Ong, Gerson S. Lichtenberg, Janine R. Shapiro, Antonio F. Amico, Mark N. Allen, Richard S. Meltzer
Journal: Journal of the American College of Cardiology (1989)
THYMUS-DEPENDENT AREAS IN THE LYMPHOID ORGANS OF NEONATALLY THYMECTOMIZED MICE
Authors: Delphine M. V. Parrott, Maria A. B. de Sousa, June East
Journal: The Journal of Experimental Medicine (1966)

Specific areas of lymphocyte depletion, termed thymus-dependent areas, have been delineated in neonatally thymectomized C3H/Bi and F(1) (C57BL x C3H/Bi) mice. They occur within the lymphoid follicles of the spleen immediately surrounding the central arterioles, and constitute the mid and deep cortical zones of the lymph nodes. These depleted areas appear in healthy thymectomized mice as early as 3 wk after operation but, in mice which survive for more than 6 to 7 wk, the thymus-dependent areas are repopulated by rapidly dividing pyroninophilic cells, the majority of which are immature plasma cells. Syngeneic thymus cells, labeled in vitro with tritiated adenosine localize preferentially in the thymus-dependent areas after intravenous injection. Similarly labeled spleen cells also accumulate in these areas but, in addition, are distributed at the periphery of splenic follicles and in the outer cortical zone of the lymph nodes. Many more spleen than thymus cells enter the lymphoid tissues and the spleen appears to be the primary target. The apparent paradox that syngeneic thymus cells are less efficient than spleen cells in restoring neonatally thymectomized mice to normality is discussed in the light of these results and possible routes by which the migrating cells could enter the lymphoid tissues are considered. The origin of the plasma cells which repopulate the lymphocyte depleted areas is also discussed. It is concluded that the normal thymus produces cells which contribute directly to the migratory or circulatory lymphocyte population but that there also exists another source of supply for the plasma cell series. These two systems may function synergistically so that the thymus may control, directly or indirectly, the balance of cell populations within the body.
Correction of Murine Hemophilia A and Immunological Differences of Factor VIII Variants Delivered by Helper-dependent Adenoviral Vectors
Authors: Vincenzo Cerullo, Michael P Seiler, Viraj Mane, Racel Cela, Christian Clarke, Randal J Kaufman, Steven W Pipe, Brendan Lee
Journal: Molecular Therapy (2007)

Bioengineering of the factor VIII (FVIII) molecule has led to the production of variants that overcome poor secretion and/or rapid inactivation. We tested six modified FVIII variants for in vivo efficacy by expressing them from helper-dependent adenoviral (HD-Ad) vectors. We constructed a wild-type (WT) variant, a B-domain-deleted (BDD) variant, a point mutant for improved secretion (F309S), a variant with a partial B-domain deletion for improved secretion (N6), a combination of the point mutant and partial BDD variant (F309N6), and an inactivation-resistant (IR8) FVIII variant. All the constructs expressed functional protein after injection of high-dose HD-Ad. Activity ranged from 20 to 50% with WT, to approximately 100% with the N6 and F309N6 variants. Interestingly, mice treated with N6 showed long-term FVIII activity and phenotypic correction for up to 74 weeks, with low anti-FVIII antibody titer. Importantly, the N6 variant was therapeutically efficacious even after a 50% reduction of viral dose, thereby indicating that transgene modification itself can improve the dose efficacy of HD-Ad. This finding is significant, because dose efficacy is a key factor in clinical application. In summary, bioengineering of the FVIII molecule may be an effective approach to improving the safety, immunogenicity, and efficacy of HD-Ad gene therapy in hemophilia A (HA).
Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation
Authors: S. Munir Alam, I. Nicholas Crispe, Nicholas R.J. Gascoigne
Journal: Immunity (1995)

We report a detailed analysis of TCR V alpha and V beta chain expression on immature versus mature thymocytes of normal, TCR beta-transgenic, and TCR alpha-hemizygous mice. Chain pairing between TCR V alpha and V beta chains is random on immature thymocytes, but individual chain pairs are selected in mature thymocytes. This indicates that V alpha-V beta chain pairing preferences are determined during thymic selection, and not as a result of structural constraints. Dual V alpha chain expression is found frequently on immature, but not mature thymocytes. It is not found in TCR alpha-hemizygous mice, showing that cell surface expression of dual alpha chains is caused by lack of allelic exclusion in immature thymocytes. Down-regulation of one of the alpha chains occurs concurrently with differentiation from TCRlo, CD69- to TCRhi, CD69+ phenotype, suggesting that it is associated with positive selection of the functional TCR.
A NOTE ON DEFECTIVE NIPPLES
Authors: H. B. Billups
Journal: BMJ (1910)

VERY much nowadays is written about excessive infantile mortality, and one of-the chief causes alleged is defective artificial feeding.The reasons for the prevalence of artificial feeding have been frequently discussed, but there is one reason on which sufficient stress is not laid-defects in the nipples of nursing mothers.I have seen a number of mothers who, although they had plenty of milk in their breasts, have yet, on this account, been unable to nurse their babiee.
Development of Ecdysone-Regulated Lentiviral Vectors
Authors: Francesco Galimi, Enrique Saez, Jason Gall, Nien Hoong, Gerald Cho, Ronald M. Evans, Inder M. Verma
Journal: Molecular Therapy (2004)

We have engineered a lentivirus-based gene transfer system to achieve ecdysone-regulated transgene expression. The method combines the wide tropism of lentiviral vectors and the possibility of gene regulation by a small molecule with an excellent pharmacological profile. Using the hematopoietic tissue as a model, we transduced mouse progenitors with an ecdysone-regulated GFP expression cassette. The ecdysone gene switch efficiently turned GFP on and off in transplanted animals, showing low basal activity. This system allows the delivery of inducible transcriptional units in vitro and ex vivo and may be a useful tool for gene transfer purposes. Moreover, our work provides hints on the design of lentiviral vectors containing multiple expression cassettes with multiple promoters.
Researchers face patent race for breast cancer gene
Authors: O. Dyer
Journal: BMJ (1996)

A team of Anglo-American researchers who recently announced their discovery of a second gene that causes breast cancer now seems likely to face a challenge from a rival American project. Myriad Genetics, based in Salt Lake City, Utah, claims to have beaten the Institute of Cancer Research in a race to isolate the gene BRCA2 and has filed an application for a US patent.

The British team, led by Dr Mike Stratton of the Institute of Cancer Research, has also filed a preliminary application for a European patent in the name of CRC Technology, the institute's technology transfer company. Myriad Genetics, meanwhile, …
Polyclonal B lymphocytosis with binucleated lymphocytes in a man
Authors: Charles Chevalier, Bernard Husson, Gautier Detry
Journal: American Journal of Hematology (2011)

A 47 year-old man followed for chronic anemia presented to our service for a routine check. His medical history showed meningitis in childhood, depression, and chronic bronchitis. This patient occasionally drinks alcohol and has actively smoked, a pack a day, for 25 years. His hematological check-up revealed microcytic (Mean corpuscular volume: 67.4 fL) hypochromic (Mean corpuscular hemoglogin concentration: 28.7 g/dL) anemia (hemoglobin concentration: 10.7 g/dL) with a low ferritin (5 ng/mL) count and an increased IgM level (934 mg/dL), unchanged from prior visits. The lymphocyte count was normal (3900/μL), but the cytological analysis showed several lymphocytes of intermediate to large size with abundant moderately basophilic cytoplasm. The nucleus presented a quadrangular or bilobed form with a small nucleolus (Images 1 and 2). As cases of B-chronic lymphocytic leukemia with such cytology features had previously been described in the literature [1], flow cytometry immunophenotyping was performed and showed B-cell hyperplasia with polyclonality of light chains (Image 3). No additional investigation was conducted. Image 1. Image 2. Image 3. Polyclonal B lymphocytosis with binucleated lymphocytes first described by Gordon et al. [2] is a rare condition preferentially affecting young women who smoke heavily [3]. Lymphocytosis is usually moderate. The etiology is unknown but tobacco plays an undeniable role. Family history and an association with HLA-DR7 have been described [4]. An increase of polyclonal IgM is reported in all patients. The conventional karyotype or fluorescence in situ hybridization paradoxically may show a clonal abnormality with isochromosome 3 being found in most cases. Evolutionarily, lymphocytosis remains stable over time. This stability makes chemotherapy treatment unnecessary, but prolonged monitoring seems necessary because some authors have described the occurrence in rare cases of large cell lymphoma [5].
Fast Fourier Transformation of EEG Data
Authors: Ira Jay Rampil
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Several opinions expressed by the Diagnostic and Therapeutic Technology Assessment (DATTA) panel on the subject of intraoperative quantitative EEG monitoring<sup>1</sup>might be considered controversial. The actual technique, Fast Fourier transform (FFT) of EEG data, is not per se a quantification of EEG data but merely a reformatting of data into component frequencies. This transformation is useful because many pathological EEG patterns produce spectral patterns that can be easily recognized without the extensive training required to interpret routine EEG tracings. The reformatting of EEG into respective frequency spectral patterns allows enormous compression in display of data over time, providing easy visualization of temporal trends. The currently available commercial EEG-FFT monitors are easy to set up and operate, obviating the need for a technician-operator, but do not provide as many EEG data channels as do routine clinical EEG recorders. The statement in the DATTA opinion that standard EEG