Levothyroxine Binding by Sucralfate
Authors: Jana Havrankova, Raymond Lahaie
Journal: Annals of Internal Medicine (1992)

Letters1 September 1992Levothyroxine Binding by SucralfateJana Havrankova, MD, Raymond Lahaie, MDJana Havrankova, MDSearch for more papers by this author, Raymond Lahaie, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-5-445_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Sucralfate is widely used in gastrointestinal ulcer therapy and as a cytoprotective agent in patients receiving anti-inflammatory agents. Because prevalence of hypothyroidism varies from 0.5% to 4%, physicians may see patients who have been treated with both levothyroxine and sucralfate. We examined a 63-year-old woman taking sucralfate, whose hypothyroidism (secondary to radioiodine treatment for diffuse toxic goiter given 8 months earlier) could not be corrected despite administration of up to 4.8 µg/kg body weight of levothyroxine, three times the usual replacement dose. When levothyroxine was taken 2.5 hours after sucralfate, the plasma thyroid-stimulating hormone (TSH) level remained...References1. McCarthy D. Sucralfate. N Engl J Med. 1991;325:1017-25. CrossrefMedlineGoogle Scholar2. NorthcuttStielHollifieldStant RJWE. The influence of cholestyramine on thyroxine absorption. JAMA. 1969;208:1857-60. CrossrefMedlineGoogle Scholar3. PhillipsSchultzStafford WJW. Effects of colestipol hydrochloride on drug absorption in the rat. I. Aspirin, L-thyroxine, phenobarbital, cortisone, and sulfadiazine. J Pharm Sci. 1974;63:1097-101. CrossrefMedlineGoogle Scholar4. SperberLiel AY. Evidence for interference with the intestinal absorption of levothyroxine sodium by aluminum hydroxide. Arch Intern Med. 1992;152:183-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hôpital Saint-Luc Montreal, Quebec H2X 3J4 Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThyroid Auto-TransplantationGastrointestinal Malabsorption of ThyroxineReview of Heterotopic Thyroid AutotransplantationFactors Affecting Gastrointestinal Absorption of Levothyroxine: A ReviewThyroid Function TestingHypothyroidism and Myxedema ComaAbsorption of Levothyroxine When Coadministered with Various Calcium FormulationsHipotiroidismo primario: consideraciones para una buena utilización del tratamiento con levotiroxinaThyroid Function TestingHypothyroidism and Myxedema ComaConditions and drugs interfering with thyroxine absorptionColesevelam Hydrochloride and Lanthanum Carbonate Interfere with the Absorption of LevothyroxineNew Medications Which Decrease Levothyroxine AbsorptionTablet Formulation of Levothyroxine Is Absorbed Less Well Than Powdered LevothyroxineInterference with the absorption of levothyroxineExaggerated Levothyroxine Malabsorption Due to Calcium Carbonate Supplementation in Gastrointestinal DisordersThe Acute Effect of Calcium Carbonate on the Intestinal Absorption of LevothyroxineConcurrent Use of Antiulcerative AgentsMedication use in the hypothyroid patientDrugs and Thyroid FunctionNonspecific intestinal adsorption of levothyroxine by aluminum hydroxideDrug Interactions with Antiulcer Agents: Considerations in the Treatment of Acid-Peptic DiseaseSucralfate causes malabsorption of L-thyroxineThyroxine interaction 1 September 1992Volume 117, Issue 5Page: 445-446KeywordsBlood plasmaBody weightHypothyroidismThyroid-stimulating hormoneThyroxineUlcers Issue Published: 1 September 1992 PDF DownloadLoading ...