tbuckley/cabot-search huggingface dataset:
Surgical Treatment of Coronary Arteriosclerosis
Authors: Colin McCord
Journal: JAMA (1971)

The rapid acceptance of bypass grafting to coronary arteries in the past two years has, for most cardiac surgeons, reduced the novelty of the procedures described in this volume, but its historic significance is unaffected. Recounted here is the development, in a ten-year period in a single institution, of coronary artery visualization by Mason Sones; internal mammary artery implantation for myocardial revascularization (using the techniques of Vineberg and Sewell, but changing the operation from a blind procedure to a carefully designed operation in which the new blood supply was introduced into the exact area of ischemia); and the introduction and perfection of saphenous vein bypass techniques by Favaloro—first to the right coronary artery, and ultimately to any artery in need of new blood supply. Further refinements of these techniques have been subsequently introduced, particularly the use of microsuture methods to permit anastomosis to very small blood vessels (Green, Jacobson, and
Will Accountable Care Organizations Deliver Greater Quality and Lower Cost Health Care?
Authors: Jay A. Harolds
Journal: Clinical Nuclear Medicine (2010)

An Accountable Care Organization (ACO) is a voluntary grouping of health care providers that is envisioned to be able to offer high quality care with lower cost than is typically provided in this country. The cost savings achieved by the ACO would be shared between the ACO and the Centers for Medicare and Medicaid Services (CMS). There are a variety of types of ACO's, and there are certain eligibility requirements. There are both benefits and risks to those participating in these ACOs.
INCREASED VASCULAR STIFFNESS MEASURED AS PULSE WAVE VELOCITY IS ASSOCIATED WITH THE PRESENCE AND SEVERITY OF CORONARY ARTERY DISEASE
Authors: Naser Ahmadi, Vahid Nabavi, Braynce L. Oyang, Shahin Moshrefi, Sagar J. Pathak, Sourya Sourya-nejad, Hussain Isma’eel, Ramin Ebrahimi, Matthew Budoff
Journal: Journal of the American College of Cardiology (2010)
Randomised equivalence trial comparing three month and six month follow up of patients with hypertension by family practitioners
Authors: R. V Birtwhistle
Journal: BMJ (2004)

To compare blood pressure control, satisfaction, and adherence to drug treatment in patients with treated hypertension followed up by their family physicians either every three months or every six months for three years.Randomised equivalence clinical trial. Settings 50 family practices in south eastern Ontario, Canada.609 patients aged 30-74 years with essential hypertension receiving drug treatment whose hypertension had been controlled for at least three months before entry into the study.302 patients were randomly assigned to follow up every three months and 307 to follow up every six months. Baseline variables in the two groups were similar. As expected, patients in the six month group had significantly fewer visits, but patients in both groups visited their doctor more frequently than their assigned interval. Mean blood pressure was similar in the groups, as was control of hypertension. Patient satisfaction and adherence to treatment were similar in the groups. About 20% of patients in each group had blood pressures that were out of control during the study.Follow up of patients with treated essential hypertension every six months is equivalent to follow up every three months. Patient satisfaction and adherence to treatment are the same for these follow up intervals. As about 20% of patients' hypertension was out of control at any time during the study in both groups, the frequency of follow up may not the most important factor in the control of patients' hypertension by family practitioners.
Evaluation of Acute Proctitis
Authors: Diane C. Halstead-McFarland
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Richard R. Babb, MD (1980;244:358), recently presented guidelines for the clinician to use in ascertaining the cause of acute proctitis, including stool analysis for infectious agents. We would like to draw attention to a more recently recognized and important cause of proctitis caused by<i>Campylobacter fetus</i>subspecies<i>jejuni</i>(1979;242:2519).<sup>1</sup>Stool samples collected during sigmoidoscopy should be delivered immediately to the microbiology laboratory where they may be examined by either darkfield or phase contrast microscopy for typical darting or corkscrew-like motility. For definitive diagnosis, comprehensive bacteriologic studies should include culturing on<i>Campylobacter</i>selective medium<sup>3</sup>incubated at 42 °C under microaerophilic conditions. Since epidemiologic studies have confirmed acquisition of disease from contaminated food, water, animals, eg, dogs with diarrhea, and slaughterhouses, patients should be questioned about these possible contacts. Severe campylobacteriosis may be clinically and histologically indistinguishable from ulcerative colitis as well as other enteric infections. Only
Isotonic Saline Subjected to Taylor-Couette-Poiseuille Flow Demonstrates Anti-Inflammatory Activity in a Rat Model of Allergic Asthma
Authors: S. Ghosh, T.L. Mega, S. German, L.M. Burke, M.L. Diegel, A.B. Wood, R.L. Watson
Journal: Journal of Allergy and Clinical Immunology (2011)
Valve Sparing Aortic Root Re-implantation (David V Procedure): Early and Midterms Results of Our Clinic
Authors: Sabit Sarıkaya, Mehmet Dedemoğlu, Ahmet Elibol, Eylül Kafalı Başaran, Fuat Büyükbayrak, Kaan Kırali
Journal: Journal of the American College of Cardiology (2013)
A LABILE COMPONENT OF NORMAL SERUM WHICH COMBINES WITH VARIOUS VIRUSES. NEUTRALIZATION OF INFECTIVITY AND INHIBITION OF HEMAGGLUTINATION BY THE COMPONENT
Authors: Harold S. Ginsberg, Frank L. Horsfall
Journal: The Journal of Experimental Medicine (1949)

A labile component present in the serum of human beings, guinea pigs, and rabbits neutralizes the infectivity of mumps, Newcastle disease, influenza A and B viruses. The labile component of these sera and of mouse serum also inhibits hemagglutination of chicken RBC by these viruses. The component is inactivated by heating at 56 degrees C. for 30 minutes and upon storage at 4 degrees C. for periods longer than 2 weeks. The virus-neutralizing and hemagglutination-inhibiting properties result from serum component-virus combination in the presence of calcium. The combination is stable, and does not undergo spontaneous dissociation. Partial separation of virus can be brought about by heating mixtures held for 24 hours or by removal of calcium ions with sodium citrate. The labile serum component appears to be distinct from hemolytic complement.
Involvement of the serine/threonine p70S6 kinase in TGF-β1-induced ADAM12 expression in cultured human hepatic stellate cells
Authors: Hélène Le Pabic, Annie L'Helgoualc'h, Alexandre Coutant, Ulla M. Wewer, Georges Baffet, Bruno Clément, Nathalie Théret
Journal: Journal of Hepatology (2005)
Cutaneous Sarcoidosis in Venepuncture Sites
Authors: I. A. Short, J. A. Milne
Journal: BMJ (1973)

the system in the ventricular septum were also severely affected, further establishing the aetiology of the heart block.These findings are characteristic of the lesions and the functional impairment that I ~~~~M-'~1 ~~~~F ig 2-The node of Tawara, recognizable above the dark-stained central fibrous body, almost completely replaced by sarcoid granulomatous tissue.(Azanx18.)seems to be peculiar to sarcoid heart disease, as stated in your leading article.-Iam, etc.,
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
Authors: Haley Hieronymus, Justin Lamb, Kenneth N. Ross, Xiao P. Peng, Cristina Clement, Anna Rodina, Maria Nieto, Jinyan Du, Kimberly Stegmaier, Srilakshmi M. Raj, Katherine N. Maloney, Jon Clardy, William C. Hahn, Gabriela Chiosis, Todd R. Golub
Journal: Cancer Cell (2006)
Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation?
Authors: C. B. ARCHER, C. P. PAGE, W. PAUL, J. MORLEY, D. M. MACDONALD
Journal: British Journal of Dermatology (1985)

The ether-linked phospholipid, Paf-acether (AGEPC) is released from a variety of inflammatory cell types and has properties consistent with those of a mediator of inflammation. We have examined the effects of locally administered Paf-acether on cellular accumulation in the skin of experimental animals and man by histological evaluation of sequential skin biopsies and quantification of accumulation of radiolabelled blood elements. In guinea-pig skin, immediate extravasation of plasma protein and intravascular accumulation of platelets and neutrophils was succeeded by a persistent mixed cellular infiltrate predominantly of neutrophils but also containing lymphocytes and histiocytes. Radiolabelling studies were consistent with these observations. Intradermal Paf-acether elicited persistent clinical and histopathological responses in human skin. The finding that Paf-acether is able to initiate cutaneous cellular accumulation may be important in the pathogenesis of inflammatory dermatoses.
TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA
Authors: Seong Gyu Jeon, Sun-Young Oh, Hye-Kyung Park, You-Sun Kim, Eun-Jin Shim, Hyun-Seung Lee, Min-Hee Oh, Boram Bang, Eun-Young Chun, Sang-Heon Kim, Yong Song Gho, Zhou Zhu, You-Young Kim, Yoon-Keun Kim
Journal: Journal of Allergy and Clinical Immunology (2007)
Transplanted Murine Long-term Repopulating Hematopoietic Cells Can Differentiate to Osteoblasts in the Marrow Stem Cell Niche
Authors: Ted J Hofmann, Satoru Otsuru, Roberta Marino, Valeria Rasini, Elena Veronesi, Alba Murgia, Jill Lahti, Kelli Boyd, Massimo Dominici, Edwin M Horwitz
Journal: Molecular Therapy (2013)

Bone marrow transplantation (BMT) can give rise to donor-derived osteopoiesis in mice and humans; however, the source of this activity, whether a primitive osteoprogenitor or a transplantable marrow cell with dual hematopoietic and osteogenic potential, has eluded detection. To address this issue, we fractionated whole BM from mice according to cell surface immunophenotype and assayed the hematopoietic and osteopoietic potentials of the transplanted cells. Here, we show that a donor marrow cell capable of robust osteopoiesis possesses a surface phenotype of c-Kit+ Lin− Sca-1+ CD34−/lo, identical to that of the long-term repopulating hematopoietic stem cell (LTR-HSC). Secondary BMT studies demonstrated that a single marrow cell able to contribute to hematopoietic reconstitution in primary recipients also drives robust osteopoiesis and LT hematopoiesis in secondary recipients. These findings indicate that LTR-HSC can give rise to progeny that differentiate to osteoblasts after BMT, suggesting a mechanism for prompt restoration of the osteoblastic HSC niche following BM injury, such as that induced by clinical BMT preparative regimens. An understanding of the mechanisms that regulate this differentiation potential may lead to novel treatments for disorders of bone as well as methods for preserving the integrity of endosteal hematopoietic niches. Bone marrow transplantation (BMT) can give rise to donor-derived osteopoiesis in mice and humans; however, the source of this activity, whether a primitive osteoprogenitor or a transplantable marrow cell with dual hematopoietic and osteogenic potential, has eluded detection. To address this issue, we fractionated whole BM from mice according to cell surface immunophenotype and assayed the hematopoietic and osteopoietic potentials of the transplanted cells. Here, we show that a donor marrow cell capable of robust osteopoiesis possesses a surface phenotype of c-Kit+ Lin− Sca-1+ CD34−/lo, identical to that of the long-term repopulating hematopoietic stem cell (LTR-HSC). Secondary BMT studies demonstrated that a single marrow cell able to contribute to hematopoietic reconstitution in primary recipients also drives robust osteopoiesis and LT hematopoiesis in secondary recipients. These findings indicate that LTR-HSC can give rise to progeny that differentiate to osteoblasts after BMT, suggesting a mechanism for prompt restoration of the osteoblastic HSC niche following BM injury, such as that induced by clinical BMT preparative regimens. An understanding of the mechanisms that regulate this differentiation potential may lead to novel treatments for disorders of bone as well as methods for preserving the integrity of endosteal hematopoietic niches.
Life without COX 2 inhibitors:Opioids can be prescribed safely in osteoarthritis
Authors: Colette M Reid, Jeremy Horwood
Journal: BMJ (2006)

EDITOR—In their editorial on life without COX 2 inhibitors Shaughnessy and Gordon give examples of drug and non-drug measures shown to be effective in osteoarthritis, but their discussion of opioids was not referenced.1 The omission of studies supporting the use of opioids was surprising, particularly when references for the non-drug measures were included even when the effect sizes were small or the data limited by small …
39 and Holding (In the Dusk With the Light Behind Her)
Authors: Thom R. Nichols
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Age is a relevant variable in most investigations of health problems, and problems of health care. When estimating an association of interest, distortion or bias can occur from inaccurate age reporting, directly affecting conclusions. In our analyses of medical malpractice claims,<sup>1</sup>we have observed remarkable age reporting preferences by both defendant physicians and plaintiffs, which suggest that this method of age determination may produce considerable inaccuracies. Physicians in general tended to report their age in five-year intervals even though the report form requested specific age. Of 11 939 physicians reporting age, 24.4% reported either 40, 45, 50, 55, 60, or 65 years. This is illustrated in Fig 1. Compared with the expected frequencies, based on the average of frequencies reported for the single-year ages directly preceding and following, the increased frequencies for these "preferred" ages ranged from +30% for age 55 years to +140% for age 60 years (<i>P</i>&lt;.001 for each). Physician gender was not reported, so male
Application of the solid phase C1q and Raji cell radioimmune assays for the detection of circulating immune complexes in glomerulonephritis.
Authors: K S Tung, A J Woodroffe, T D Ahlin, R C Williams, C B Wilson
Journal: Journal of Clinical Investigation (1978)

The C1q solid phase and Raji cell radioimmune assays were used to determine the frequency of detectable circulating immune complexes in patients with glomerulonephritis. In this study, 46% of 56 patients with glomerulonephritis had evidence of circulating immune complexes. More important, circulating immune complexes were associated with some, but not other, types of glomerulonephritis. Thus, immune complexes were detected in lupus glomerulonephritis (9/9 patients), rapidly progressive glomerulonephritis (5/6 patients), and acute nephritis (5/6 patients), but not in IgA-IgG glomerulonephritis (0/7 patients), or membranous glomerulonephritis (0/8 patients). The Raji cell radioimmune assay and the C1q solid phase radioimmune assay showed concordance of 79% in the detection of circulating immune complexes. Serial determinations, in general, showed either persistence of a negative or positive result of conversion of positive to negative.
Lead toxicity: current concerns.
Authors: R A Goyer
Journal: Environmental Health Perspectives (1993)

Over the 20-year period since the first issue of Environmental Health Perspectives was published, there has been considerable progress in the understanding of the potential toxicity of exposure to lead. Many of these advances have been reviewed in published symposia, conferences, and review papers in EHP. This brief review identifies major advances as well as a number of current concerns that present opportunities for prevention and intervention strategies. The major scientific advance has been the demonstration that blood lead (PbB) levels of 10-15 micrograms/dL in newborn and very young infants result in cognitive and behavioral deficits. Further support for this observation is being obtained by prospective or longitudinal studies presently in progress. The mechanism(s) for the central nervous system effects of lead is unclear but involve lead interactions within calcium-mediated intracellular messenger systems and neurotransmission. Effects of low-level lead exposure on blood pressure, particularly in adult men, may be related to the effect of lead on calcium-mediated control of vascular smooth muscle contraction and on the renin-angiotensin system. Reproductive effects of lead have long been suspected, but low-level effects have not been well studied. Whether lead is a carcinogen or its association with renal adenocarcinoma is a consequence of cystic nephropathy is uncertain. Major risk factors for lead toxicity in children in the United States include nutrition, particularly deficiencies of essential metals, calcium, iron, and zinc, and housing and socioeconomic status. A goal for the year 2000 is to reduce prevalence of blood lead levels exceeding 15 micrograms/dL.
TCT-439 First Report of Short Term and Long Term Outcomes from a Confirmatory Study of Percutaneous Ventricular Restoration (PVR) therapy using the Parachute(r) Device in Patients with Ischemic Dilated Heart Failure
Authors: Marco Costa, Martyn Thomas, Andrejs Erglis, Vasco G. Ribeiro, Hüseyin Ince, Christoph A. Nienaber, Ruiz C. Ferreira, Corrado Tamburino, William Abraham
Journal: Journal of the American College of Cardiology (2013)
Abstract P1-02-02: Concordance of microarray based determination of ER, PR and HER2 receptor status and local IHC/FISH assessment in the prospective neo-adjuvant breast registry symphony trial (NBRST)
Authors: P Beitsch, M Gittleman, S Akbari, L Stork-Sloots, F de Snoo, J Gibson, P Whitworth
Journal: Cancer Research (2013)

Abstract Background The level of estrogen receptor (ER), progesterone receptor (PR) and HER2 expression is predictive for prognosis and/or treatment response in breast cancer patients. However, differences in fixation and IHC and subjective interpretation can substantially affect the accuracy and reproducibility of the results. The commercially available TargetPrint test measures the mRNA expression level of ER, PR and HER2. Previously TargetPrint was shown to be strongly correlated with high quality IHC/FISH assessment, especially for ER and HER2. Concordance rates were 98% (k = 0.90) for ER; 85% (k = 0.62) for PR and 96% for HER2 (k = 0.78) in 619 patients (Viale et al., SABCS 2011). This study compares results from the microarray-based TargetPrint with IHC and FISH conducted according to local standard procedures in the prospective NBRST study. Methods The NBRST study includes women aged 18–90 with histologically proven breast cancer, who are scheduled to start neo-adjuvant chemotherapy (CT) or neo-adjuvant endocrine therapy (ET), and who provide written informed consent. The mRNA level of ER, PR and HER2 (TargetPrint) was assessed at the Agendia laboratory (Agendia Inc, Irvine, CA) in fresh and formalin fixed paraffin embedded tumor samples submitted from 40 institutes in the US. The results of the IHC/FISH assessments conducted according to local standard procedures were compared to the quantitative gene expression readouts. Results There were 355 eligible patients enrolled. 67% of patients are IHC ER positive and 25% Her2 IHC/FISH positive. 11 patients were IHC/FISH HER2 equivocal (all TargetPrint HER2 negative). Comparison of IHC and gene expression read out by TargetPrint showed a concordance of 88% (k = 0.75)for ER; 83% (k = 0.66) for PR and 89% (k = 0.70) for HER2. The discordance range for institutes who submitted more than 10 samples was 0-30% for ER, 0-47% for PR and 0-28% for HER2. 16% of all IHC ER+ samples were classified negative by microarray. In contrast, 4% of IHC ER- samples were classified positive by microarray. However for HER2, as many as 33% of IHC/FISH HER2+ samples were classified negative by microarray; 3% of IHC/FISH HER2- samples were classified positive by microarray. Conclusions Microarray based readout of ER, PR and HER2 status using TargetPrint is comparable to local IHC and FISH analysis in 355 analyzed samples from 40 US institutes but the discordance range for individual institutes was up to 30% for ER and 28% for Her2. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-02-02.
Microaerosols; physiology, pharmacology, therapeutics.
Authors: David W. Cugell
Journal: JAMA (1963)

In this small volume Dr. Dautreband of Belgium has summarized his extensive contributions over the past 30 years. Among the best of the twenty-two chapters are those pertaining to the technical aspects of aerosol production, the collective administration of aerosols to workers in dusty occupations, and the methods of sampling and sizing aerosol particles.  There are 38 pages of references, but not all sections are equally well documented. Physiological studies, particularly in man, are well annotated, whereas pharmacologic experiments and the technical aspects of aerosols and aerosol production are irregularly documented. There are frequent references to corroborative findings, but few to conclusions at variance with those obtained by the author. The use of numerical references instead of proper names would have made the text somewhat easier to read. The author occasionally displays considerable physiological naivete, particularly in his conclusions about carbon dioxide transfer. On the other hand, he uses ingenious
Intestinal Sucrase — Isomaltase Deficiency and Renal Calculi
Authors: C. Wayne Starnes, Jack D. Welsh
Journal: New England Journal of Medicine (1970)

SINCE the report in 1964 of the first adult with sucrase-isomaltase deficiency proved by assays of intestinal enzymes,1 nine documented cases in adults have been described.2 3 4 5 6 7 The presence of the enzyme defect and renal calculus in two of our patients prompted the following report.Case ReportsD.B., a 45-year-old-man, was studied in 1966 because of diarrhea. He had had severe feeding problems as an infant, but later childhood development was normal. As an adult abdominal pain, flatulence and watery diarrhea developed when he ate sucrose. He passed renal stones on 4 occasions, the 1st time in 1944 and the last . . .
Surgical Management of Descending Thoracic Aortic Disease: Open and Endovascular Approaches
Authors: Michael A. Coady, John S. Ikonomidis, Albert T. Cheung, Alan H. Matsumoto, Michael D. Dake, Elliot L. Chaikof, Richard P. Cambria, Christina T. Mora-Mangano, Thoralf M. Sundt, Frank W. Sellke
Journal: Circulation (2010)