tbuckley/cabot-search huggingface dataset:
Necrosis of the Hand After Daunorubicin Infusion Distal to an Arteriovenous Fistula
Authors: LEON H. DRAGON
Journal: Annals of Internal Medicine (1979)

Brief Reports1 July 1979Necrosis of the Hand After Daunorubicin Infusion Distal to an Arteriovenous FistulaLEON H. DRAGON, M.D., HAYDEN G. BRAINE, M.D.LEON H. DRAGON, M.D.Search for more papers by this author, HAYDEN G. BRAINE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-58 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with malignant disease who receive repeated intravenous injections of various chemotherapeutic agents may develop difficulty secondary to insufficient venous access. Previously reported experience with surgicalarteriovenous fistulas (1) and bovine heterografts (2) has shown that these techniques may improve long-term venous access if they are used while a suitable vein for venous outflow still exists. The morbidity of these procedures has been related to the expected risks of the surgical procedures and, on occasion, to high output cardiac failure. Complications resulting from administration of drugs and blood products into the fistula have not been reported. We report here a...References1. STECKLERMORTENSPEERMCCREDIE RRJK. Vascular access by means of surgically created arteriovenous fistulas in the chemotherapy of acute leukemia. South Med J. 1974;67:821-4. CrossrefMedlineGoogle Scholar2. LEMPERTKNIGHTKARMONDY NEA. Vascular access for cancer chemotherapy. JAMA. 1977;237:1964. CrossrefMedlineGoogle Scholar3. RUDOLPHSTEINPATTILLO RRR. Skin ulcers due to adriamycin. Cancer. 1976;38:1087-94. CrossrefMedlineGoogle Scholar4. HASKELLSILVERSTEINRANGELHUNTSPARKSMORTON CMDJFD. Multimodality cancer therapy in man: a pilot study of adriamycin by arterial infusion. Cancer. 1974;33:1485-90. CrossrefGoogle Scholar5. REILLYNEIFELDROSENBERG JJS. Clinical course and management of accidental adriamycin extravasation. Cancer. 1977;40:2053-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LEON H. DRAGON, M.D.; HAYDEN G. BRAINE, M.D.Affiliations: The Johns Hopkins Oncology Center Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTopoisomerase-Interacting AgentsDaunorubicinDaunorubicinMeasuresDaunorubicinAcquired Aplastic Anemia: Classification and Etiologic ConsiderationsPharmacological Considerations for Renal Failure and DialysisPharmacological Aspects of Renal Failure and DialysisDaunorubicin (z.B. Daunoblastin®) 1 July 1979Volume 91, Issue 1Page: 58-59KeywordsDrug administrationDrugsEdemaErythemaFistulasHeart failureIntravenous injectionsMorbidityNecrosisVeins ePublished: 1 December 2008 Issue Published: 1 July 1979 PDF downloadLoading ...
Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2 by juxtaposition with MBNL1 and STAG2
Authors: S Chen, S Nagel, B Schneider, M Kaufmann, C Meyer, M Zaborski, U R Kees, H G Drexler, R A F MacLeod
Journal: Leukemia (2011)
Levels of peripheral CD4+FoxP3+ regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer
Authors: Xin Yao, Mojgan Ahmadzadeh, Yong-Chen Lu, David J. Liewehr, Mark E. Dudley, Fang Liu, David S. Schrump, Seth M. Steinberg, Steven A. Rosenberg, Paul F. Robbins
Journal: Blood (2012)
Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular lymphoma
Authors: Masanori Daibata, Nobuo Hatakeyama, Mikio Kamioka, Yuiko Nemoto, Makoto Hiroi, Isao Miyoshi, Hirokuni Taguchi
Journal: American Journal of Hematology (2001)

Abstract Progressive multifocal leukoencephalopathy (PML), a demyelinating infectious disease caused by JC virus (JCV), occurs almost exclusively in immunocompromised patients usually with malignant diseases. We report here a Japanese female with follicular lymphoma who subsequently developed PML. In addition to JCV, human herpesvirus 6 (HHV‐6) was detected in the affected brain lesions of the patient by polymerase chain reaction and by in situ hybridization. HHV‐6, recognized as a neurotropic virus, is known to be reactivated during immunosuppression and can cause fatal complications such as encephalitis/encephalopathy. It is likely that impaired immunity associated with lymphoma and the additional immunosuppression following cytopenia‐inducing chemotherapies predisposed the patient to reactivated HHV‐6 infection. Although it remains to be clarified whether HHV‐6 plays an important role as a co‐agent with JCV in causing demyelination of the brain, our observation alerts physicians to the possible association of HHV‐6 with the pathogenesis of PML. Am. J. Hematol. 67:200–205, 2001. © 2001 Wiley‐Liss, Inc.
ln-111-Labeled Leukocyte Scan Demonstrating Septic Meningitis Complicating a Spinal Epidural Abscess
Authors: RICHARD A. BEDONT, FREDERICK L. DATZ
Journal: Clinical Nuclear Medicine (1985)

Imaging leukocytes labeled with ln-111 tropolone correctly identified clinically inapparent septic meningitis in a 22-year-old man with a spinal epidural abscess. The meningitis was secondary to microscopic communication between the abscess and the thecal sac.
Challenge for emergency physicians
Authors: H. Herkner
Journal: BMJ (2003)

Aortic dissection is relatively rare,1 but because patients may die rapidly doctors need to bear it in mind when patients present with chest pain. The likelihood of encountering a case of aortic dissection is higher in emergency departments than in primary care. In our department, located in a 2000 bed university hospital, we see about one patient a week with acute aortic disease.2 The fact that most electronic …
Severe Acute Fibrinogenopenia Apparently Caused by Reaction to Drugs
Authors: Roger L. Trinkner, Herbert A. Perkins
Journal: JAMA (1964)

THE SUDDEN ONSET of a severe generalized bleeding syndrome in a previously healthy patient is an unusual event. Prompt therapy is required, yet time does not permit the laboratory studies needed for complete analysis of a blood-coagulation defect. Inappropriate therapy will be useless and, on occasion, severely detrimental to the patient's chances of survival. The following case is unique in that gross bleeding due to an acute fibrinolytic state appears to have been initiated by a drug-induced hypersensitivity reaction. <h3>Report of a Case</h3> A 61-year-old Filipino male, entered the Veterans Administration Hospital in San Francisco, on April 29, 1963, complaining of palpitations of five months' duration. He had been in excellent health with the exception of recurrent attacks of gout during the past year. He had taken no medications other than colchicine and a compound of acetyl-salicylic acid, acetophenetidin and caffeine (Empirin), and had no past history of allergic manifestations.
The effect of hydrocortisone on immunoglobulin metabolism
Authors: Arthur L. Levy, Thomas A. Waldmann
Journal: Journal of Clinical Investigation (1970)

The serum concentration of all subclasses of IgG (gamma(2)A, gamma(2)B, and gamma(1)) as well as IgA and IgM were reduced in normal and low pathogen mice receiving hydrocortisone acetate. Turnover studies using (131)I-labeled gamma(2)A subclass of IgG demonstrated that high dose corticosteroids cause a significantly shortened survival (increased catabolic rate) which contributes to the observed hypogammaglobulinemia. This increase in fractional catabolism is not due to excess loss in the urine or stool but reflects an increase in endogenous catabolism.
END-TO-END APPROXIMATION OF THE BROAD LIGAMENTS AND OTHER POINTS OF TECHNIQUE IN ABDOMINAL HYSTERO-MYOMECTOMY.
Authors: E. C. DUDLEY
Journal: JAMA (1902)

Abdominal hystero-myomectomy may be, supravaginal, in which the tumor, corpus uteri and supravaginal portion of the cervix are removed, or, complete, in which the tumor and entire uterus are removed. The two operations will be considered separately. <h3>SUPRAVAGINAL HYSTERO-MYOMECTOMY.</h3> The usual operation is to secure the ovarian and uterine arteries by means of strong catgut ligatures and after the removal of the tumor, corpus uteri and supravaginal portion of the cervix, to close the uterine stump by means of a continuous suture running from side to side and then to close the wound in the broad ligaments by means of another continuous suture also running in the same direction (Fig. 1). This method is open to the following objections: 1. The severed broad ligaments retract to the sides of the pelvis where they can no longer give adequate support to the bladder, vagina and the rectum, and where they consequently
Kinetic identification of an intracellular calcium compartment sensitive to phosphate and dinitrophenol in intact isolated rabbit aorta.
Authors: C M Hai, R D Phair
Journal: Circulation Research (1986)

Previous work from this laboratory revealed the presence of at least three distinct intracellular calcium compartments in intact segments of rabbit aorta. In this study one of these intracellular compartments is shown to be sensitive to dinitrophenol and to increased extracellular phosphate. Intact aortic segments were loaded with 45Ca in bicarbonate-buffered physiologic salt solution for 1 hour, and then transferred to a flow-through chamber perfused with physiologic salt solution. Effluent from the chamber was collected for 8 hours, and 45Ca efflux curves were analyzed using compartmental analysis. When aortic segments were loaded and washed out in dinitrophenol, the slowest component of the efflux curve was less prominent; in high phosphate it was more prominent. The rate constant changes required to account for these data were primarily in the exchange between the cytosolic and slowest intracellular calcium compartment, suggesting that the slowest calcium compartment resolved during the 8-hour washout was mitochondrial. This compartment contained 5.4 +/- 3.2 nmol calcium/g wet wt. tissue. The calcium flux across its membranes was 0.32 +/- 0.04 nmol min-1g-1. Because this flux is much smaller than the plasma-membrane calcium flux, we suggest that, in normal physiological circumstances, plasma-membrane extrusion is more important for the removal of Ca from the smooth muscle cytosol than is uptake into this slow intracellular compartment.
Rapid complete cytogenetic remission after upfront dasatinib monotherapy in a patient with a NUP214-ABL1-positive T-cell acute lymphoblastic leukemia
Authors: W Deenik, H B Beverloo, S C P A M van der Poel-van de Luytgaarde, M M Wattel, J W J van Esser, P J M Valk, J J Cornelissen
Journal: Leukemia (2008)
Weight Reduction With Low-Calorie Diets
Authors: Sanford H. Roth
Journal: JAMA (1968)

<h3>To the Editor:—</h3> In an incisive, well-written report (<b>202</b>:118, 1967) Dr. E. J. Drenick details the clinical consequences of a 200 to 600 calorie diet. One area of the report deserves special comment. Dr. Drenick suggests that probenecid or allopurinol is to be used in combination with such a diet as "all patients who are fed diets low enough in calories and carbohydrates to produce ketonemia should be treated prophylactically with a uricosuric agent or xanthine oxidase inhibitor" presumably to prevent gouty (arthritic) attacks. In his classical treatise on gout, Talbott defines the clinical characteristics which are the hallmark of the gouty patient.<sup>1</sup>Gouty arthritis diathesis is fortunately infrequent in the absence of a genetic predisposition, and usual sexual (predominantly male), chronological (usually middle life and beyond) factors, or previous hyperuricemia or uric acid urinary lithiasis. When such features are absent we would, in the example of Dr.
Adhesion molecules in inflammatory bowel disease.
Authors: S C Jones, R E Banks, A Haidar, A J Gearing, I K Hemingway, S H Ibbotson, M F Dixon, A T Axon
Journal: Gut (1995)

The ability of leucocytes to adhere to endothelium is essential for leucocyte migration into inflammatory sites. Some of these adhesion molecules are released from the cell surface and can be detected in serum. The soluble adhesion molecules intercellular adhesion molecule 1 (ICAM-1), E selectin, and vascular cell adhesion molecule 1 (VCAM-1) were studied in the serum of patients with Crohn's disease, ulcerative colitis, and healthy controls. A second blood sample was taken from patients with active disease after one month of treatment and a third two months after remission was achieved. Tissue expression of the same adhesion molecules was studied by immunohistology. Circulating VCAM-1 concentrations were significantly higher in patients with active ulcerative colitis (n = 11, median = 165 U/ml) compared with patients with inactive ulcerative colitis (n = 10, median = 117 U/ml, p < 0.005), active Crohn's disease (n = 12, median = 124 U/ml, p < 0.02), and controls (n = 90, median = 50 U/ml, p < 0.0001). Within each disease group there were no significant differences in E selectin or ICAM-1 concentrations between the active and inactive states, however, patients with active Crohn's disease had significantly higher ICAM-1 concentrations (n = 12, median = 273 ng/ml) than controls (n = 28, median = 168, p < 0.003). VCAM-1 concentrations fell significantly from pretreatment values to remission in active ulcerative colitis (p < 0.01). In Crohn's disease there was a significant fall in ICAM-1 both during treatment (p < 0.01) and two months after remission (p < 0.02). Vascular expression of ICAM-1 occurred more often and was more intense in inflamed tissue sections from patients with ulcerative colitis and Crohn's disease than from controls. Vascular labelling with antibody to E selectin also occurred more often in patients with active inflammatory bowel disease. In conclusion, increased circulating concentrations of selected adhesion molecules are associated with inflammatory bowel disease. There is also evidence of local upregulation, particularly of ICAM-1. Differential expression of adhesion molecules in tissue may play a part in the initiation of leucocyte migration and local inflammation; the function of circulating adhesion molecules is unknown, but may play a physiological part in blocking adhesion.
ON FAeCAL FERMENTATION AS A SOURCE OF DISEASE
Authors: C. H. F. Routh
Journal: BMJ (1856)

Intermissions re seldom seen, and remissions even are rarely obtained.Organic visceral complications are almost universal, the liver and spleen being chiefly affected; and not unfrequently the disease assumes a malignant typhoid type.Should the patient recover from the first attack of the fever, it still lingers upon him for months, or even years, recurring at the new or full moon with the greatest regularity.In 1849 and 1850, a considerable party of Eu- ropeans was located at Mohamreh, where they were en- camped on a dry plain, about a mile to the north of the town, just outside the gardens.They suffered severely from fever, which proved very fatal amongst the escort of Turkish troops; but all were affected with a disagreeable complaint, to which they could assign no cause, and which no precautions could prevent.This was a constant vonmiting after meals, which affected not only the party residing there, but also their visitors who remained with them for a day or two.It at length became so general and so dis- tressing, that they gave up eating breakfast, and all be- -came emaciated to a great degree.That this was not caused by anything deleterious in the dict, was proved by
THE ORTHOPEDIC AND PHYSICAL THERAPEUTIC TREATMENT OF CHRONIC ARTHRITIS
Authors: LORING T. SWAIM
Journal: JAMA (1934)

The orthopedic treatment of chronic arthritis should start at the very beginning of the arthritis and should be carried along in close cooperation with the medical care. There are three objectives in the treatment of chronic arthritis: (1) to control and stop the disease, (2) to prevent deformity during the course of the disease, and (3) to restore the patient to his normal life as functionally capable as possible. A fourth objective might be added to prevent recurrence of the disease. This might seem unnecessary but is an important factor in the follow up of every case. I consider this as important as any part of the treatment, since relapses are common. The medical problem in the first of these objectives demanded of treatment I shall not discuss, yet there is a very practical way in which the orthopedist can materially aid in the success of the medical treatment. He
“Big Data” in the Intensive Care Unit. Closing the Data Loop
Authors: Leo Anthony Celi, Roger G. Mark, David J. Stone, Robert A. Montgomery
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Closing the Data LoopThe data generated in the process of medical care has historically not just been underused, it has been wasted.This was due in part to the difficulty of accessing, organizing, and using data entered on paper charts, but notable variability in clinical documentation methods and quality made the problem even more challenging.In the absence of a practical way to systematically capture, analyze, and integrate the information contained in the massive amount of data generated during patient care, medicine has remained a highly empirical process in which the disconnected application of individual experiences and subjective preferences continues to thwart continuous improvement and consistent delivery of best practices to all patients.
Abstract 1975: AICAR induces cell death in LKB1-deficient NSCLC.
Authors: Fakeng Liu, Wei Zhou, Xiuju Liu, Shi-yong Sun, Fadlo Khuri, Yu-long He, Diansheng Zhong
Journal: Cancer Research (2013)

Abstract AICAR is a well known AMPK activator, and AICAR-induced AMPK activation has been shown to inhibit cell proliferation or induce apoptosis through various mechanisms, such as the inactivation of metabolic enzyme involved ATP consumption, the inhibition of the of fatty acid synthesisPI3K/AKT pathway, the activation of cell cycle regulators, or the activation of the JNK pathway. LKB1 is an upstream AMPK kinase, and energetic stress-induced AMPK activation usually requires LKB1. Interestingly, AICAR has also been shown to induce caspase-3 cleavage in LKB1- null MEF and ovarian cancer cells, indicating AICAR can induce cell killing through an AMPK- independent mechanism. Because LKB1 is most frequently inactivated in non-small cell lung cancer, we evaluated the effect of AICAR in lung cancer cell lines. AICAR preferentially induced caspase-3 cleavage in LKB1- mutant NSCLC cell lines H157, A549, H460 and H1944, but not in LKB1- wild type cell lines H1299, H358, H1650 and H1792. Transient depletion of LKB1 by RNAi in H1299 and H1792 cells promoted AICAR-induced caaspase-3 cleavage in the absence of AMPK activation, supporting the notion that AICAR induces cell killing in LKB1-depleted cells through an AMPK- independent mechanism. In LKB1-null H460 cells, AICAR treatment led to a significant increase in S phase cell populations, and G1 cell cycle arrest by serum starvation is was sufficient to prevent AICAR-induced cell death. These data indicated that AICAR-induced cell killing in LKB1- deficient cells is cell cycle dependent. In summary, the ability of AICAR to preferentially induce cell death in LKB1- deficient NSCLC suggestsed that LKB1 deficiency may be a therapeutic target for the treatment of NSCLC. Citation Format: Fakeng Liu, Wei Zhou, Xiuju Liu, Shi-yong Sun, Fadlo Khuri, Yu-long He, Diansheng Zhong. AICAR induces cell death in LKB1-deficient NSCLC. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1975. doi:10.1158/1538-7445.AM2013-1975
STUDY OF THE TREATMENT IN ACUTE TETANUS
Authors: FREDERIC W. TAYLOR
Journal: JAMA (1934)

The results obtained from the treatment of active tetanus cases are far from satisfactory. Mortality statistics on this disease vary considerably from different sources but lack any constant variation that would indicate a desirability of one form of therapy over another. The only constant variation in these statistics is found in a comparison of cases with long and with short incubation periods. This is well illustrated in the cases of Calvin and Goldberg. 1 They found a mortality of 84 per cent when the incubation was less than five days, of 83 per cent when it was from five to ten days, of 37 per cent when it was from ten to fourteen days, and of 25 per cent when it was from fourteen to twenty-one days.  Until the last few years much clinical investigation has been directed toward determining the most efficacious route of administering tetanus antitoxin. Most failures
Continuing medical education through television
Authors: S. S. Meighan
Journal: JAMA (1967)

Many physicians do not participate in organized continuing medical education. While some show reluctance to accept their need to become involved, others express concern that they lack the opportunity to influence the design of the educational courses offered. The Oregon Medical Association, therefore, decided to sponsor a series of television programs for the continuing education of its members. By the placement of this responsibility in the state medical association, the entire membership theoretically becomes involved in attempting to design and organize an effective system of continuing medical education. <h3>Organization</h3> Plans for program production were laid at a meeting of the television committee of the medical association and the production staff of Oregon Educational Broadcasting (part of the Oregon State System of Higher Education). The television committee then selected 17 physicians and made each responsible for the development of one program. Criteria for the selection of these physicians were vague; a
Family Bonds: Adoption and the Politics of Parenting
Authors: Harriet S. Meyer
Journal: JAMA (1993)

<b>Stories of Adoption: Loss and Reunion</b>, by Eric Blau, 131 pp, with illus, paper, $16.95, ISBN 0-939165-17-1, Pasadena, Calif, NewSage Press, 1993. <i>In Family Bonds</i>Elizabeth Bartholet, a professor of law at Harvard, combines personal experience and professional perspective to criticize the state of adoption and assisted reproduction in this country and to offer proposals for the reform of both. Although adoption has its own history while reproductive technology has proceeded independently apace, Bartholet's social perspective on parenting examines the two both separately and together. In her view, couples expend too much time, energy, and heartache in fertility workups, while adoption remains exclusivist, overregulated, and stigmatized. In light of her own experiences with childbirth, unsuccessful in vitro fertilization (IVF), and international adoption, she writes, "There may be some inborn need to procreate, but there are also inborn needs to nurture. Why does organized society seem to want to encourage its