tbuckley/cabot-search huggingface dataset:
Abstract P6-07-29: Independent prognostic value of age depends on breast cancer subtype
Authors: O Brouckaert, R Salihi, A Laenen, J Vanderhaegen, F Amant, K Leunen, A Smeets, P Berteloot, E Van Limbergen, C Weltens, P Moerman, S Peeters, R Paridaens, G Floris, H Wildiers, I Vergote, M-R Christiaens, P Neven
Journal: Cancer Research (2012)

Abstract Background: Whether age is an independent prognostic factor in early breast cancer remains controversial. Different cut-off values have been suggested in different studies and few studies assessed its value in triple negative breast cancer and other phenotypes. Methods: We included all primary operable breast cancer patients from our prospectively managed database in UZ Leuven, Belgium. We excluded male patients, patients treated elsewhere first, patients treated with primary systemic treatment first. We assessed the effect of age as a continuous and categorical variable for distant metastasis free interval (DMFI), locoregional free interval (LRRFI) and breast cancer specific survival (BCSS) in multivariable analysis (correcting for phenotype, tumor size, nodal status, chemo−, endocrine−, radiotherapy, type of breast and axillary surgery). We assessed the effect of age for DMFI, LRRFI and BCSS in basal-like breast cancer and other phenotypes. Results: We included 4318 patients with a mean/median age of 58/ 57 years (1170 patients were younger than 50 years) and with a median follow-up of 6,0 years. Multivariate analysis confirmed age as an independent prognostic variable for LLRFI (HR1.91; 95% CL:1.33–2.74; p = 0.0005), DMFI (HR:1.77; 95% CL:1.33–2.36; P &amp;lt; 0.0001) and BCSS (HR:2.35; 95% CL:1.66–2.74; P &amp;lt; 0.0001). The optimal cut-off value is 41years for LLRFI and BCSS and 44 years for DMFI. We did not find an independent prognostic value for age in triple negative breast cancer regarding DMFI and LRRFI. Results for other subtypes are subject to currently ongoing analyses. Conclusions: Overall, young age in primary operable breast cancer patients is an independent prognostic value for DMFI, LRRFI and BCSS after adjusting for known prognostic factors. In triple negative breast cancer, age did not retain independent prognostic value for DMFI and LRRFI. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P6-07-29.
Life and Death and the Automobile
Authors: ROBERT C. BUXBAUM
Journal: Annals of Internal Medicine (1966)

Editorials1 July 1966Life and Death and the AutomobileROBERT C. BUXBAUM, M.D.ROBERT C. BUXBAUM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-1-191 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor the 50,000 persons who will have died in traffic accidents by the end of 1966, any discussion of a better life will be useless. The problem of death and injury is of such magnitude as to shove almost all discussion aside until a solution is found. This is as it should be, since prevention of death, for physicians at least, is primary. Nevertheless, as physicians we should not be blind to the myriad other problems which lie just below the surface of motor vehicle accidents.The most critical of these is the effect of automobiles upon the quality of...References1. PRICE DJ: Little Science, Big Science. Columbia University Press, New York, 1963. CrossrefGoogle Scholar2. BUXBAUMCOLTON RCT: The relationship of motor vehicle inspection to accident mortality rates. JAMA. In press, July, 1966. CrossrefMedlineGoogle Scholar3. NAIRN I: The American Landscape: A Critical View. Random House, New York, 1965. Google Scholar4. LANGER EThe best summary of this episode may be found in the article by : Auto safety: Nader vs. General Motors. Science, 152: 47, (April 1) 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOutlook for Treating Patients with Self-Destructive HabitsJOHN F. BURNUM, M.D., F.A.C.P. 1 July 1966Volume 65, Issue 1Page: 191-193 Issue Published: 1 July 1966 PDF DownloadLoading ...
The Practical Use of a Cooling Device to Inhibit the Cutaneous Pain of Hypodermic Injections
Authors: Harry L. Mueller
Journal: New England Journal of Medicine (1953)

THE pain, discomfort, unpleasantness and anxiety attendant upon hypodermic injections given to children is well known to most physicians, particularly to those, such as pediatricians and allergists, who routinely administer a large number of hypodermic injections. The fear of anticipation is often much worse than the actual pain of the injection and is frequently translated into unpleasant disturbances in the reception room of the office or on the wards and in the outpatient clinics of the hospital. Extreme examples have been noted in children who start to scream as the car in which they are riding approaches or passes the . . .
Medication Cost Sharing and Health Outcomes in Children With Asthma
Authors: Wendy J. Ungar
Journal: JAMA (2012)

1. Lloyd-Jones DM, Hong Y, Labarthe D, et al; American Heart Association Strategic Planning Task Force and Statistics Committee. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s Strategic Impact Goal through 2020 and beyond. Circulation. 2010; 121(4):586-613. 2. Rose G. Sick individuals and sick populations. Int J Epidemiol. 1985;14(1): 32-38. 3. Rose G. The Strategy of Preventive Medicine. New York, NY: Oxford University Press; 1992. 4. Strasser T. Reflections on cardiovascular diseases. Interdiscip Sci Rev. 1978; 3(3):225-230. 5. Yang Q, Cogswell ME, Flanders WD, et al. Trends in cardiovascular health metrics and associations with all-cause and CVD mortality among US adults [published online March 16, 2012]. JAMA. 2012;307(12):1273-1283. 6. Bambs C, Kip KE, Dinga A, Mulukutla SR, Aiyer AN, Reis SE. Low prevalence of “ideal cardiovascular health” in a community-based population: the heart strategies concentrating on risk evaluation (Heart SCORE) study. Circulation. 2011; 123(8):850-857. 7. Ford ES, Greenlund KJ, Hong Y. Ideal cardiovascular health and mortality from all causes and diseases of the circulatory system among adults in the United States [published online January 30, 2012]. Circulation. doi:10.1161/CIRCULATIONAHA .111.049122. 8. Folsom AR, Yatsuya H, Nettleton JA, Lutsey PL, Cushman M, Rosamond WD; ARIC Study Investigators. Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidence. J Am Coll Cardiol. 2011;57(16):1690-1696. 9. Roger VL, Go AS, Lloyd-Jones DM, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2012 update: a report from the American Heart Association. Circulation. 2012;125(1):e2-e220. 10. Liu K, Daviglus ML, Loria C, et al. Healthy lifestyle through young adulthood and presence of low cardiovascular disease risk profile in middle age [published online January 30, 2012]. Circulation. doi:10.1161/CIRCULATIONAHA.111 .060681. 11. Koh HK, Sebelius KG. Promoting prevention through the Affordable Care Act. N Engl J Med. 2010;363(14):1296-1299. 12. Frieden TR, Berwick DM. The “Million Hearts” initiative—preventing heart attacks and strokes. N Engl J Med. 2011;365(13):e27. 13. My Life Check. American Heart Association website. http://mylifecheck.heart .org. Accessed February 29, 2012.
Prazosin, Diuretics, and Glucose Intolerance
Authors: Ivan Berlin
Journal: Annals of Internal Medicine (1993)

Letters15 October 1993Prazosin, Diuretics, and Glucose IntoleranceIvan Berlin, MDIvan Berlin, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-8-199310150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent review of drug-induced disorders of glucose tolerance, Pandit and colleagues [1] state that prazosin, an -1-adrenoceptor antagonist, may improve glucose tolerance through increased glucose-dependent insulin secretion. They suggest that this effect results from decreased -2-adrenoceptor stimulation [2].However, Broadstone and colleagues [2] tested phentolamine, an -1-adrenoceptor and -2-adrenoceptor antagonist, and found that this agent improved glucose-potentiated insulin secretion in patients with non–insulin-dependent diabetes mellitus. Because -adrenoceptors on pancreatic -cells are of the -2 subtype [3], this effect of phentolamine can only be attributed to an -2-adrenoceptor and not -1-adrenoceptor blockade. To our knowledge, there ...References1. Pandit MK, Burke J, Gustafson AB, Minocha A, Peiris AN. Drug-induced disorders of glucose tolerance. Ann Intern Med. 1993; 118: 529-39. Google Scholar2. Broadstone VI, Pfeifer MA, Bajaj V, Stagner JI, Samols E. Alpha-adrenergic blockade improves glucose-potentiated insulin secretion in non–insulin-dependent diabetes mellitus. Diabetes. 1987; 36:932-7. Google Scholar3. Nakadate T, Nakaki T, Muraki T, Kato R. Adrenergic regulation of blood glucose levels: possible involvement of postsynaptic -2 type adrenergic receptors regulating insulin release. J Pharmacol Exp Ther. 1980; 215:226-30. Google Scholar4. Baron AD. Vascular tone and insulin sensitivity: a potential role for blockade. Seventh Scientific Meeting of the American Society of Hypertension. Symposium: Sympathetic activation, blockade, and cardiovascular risk factors: putting the pieces together. New York; 6 May 1992. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1993Volume 119, Issue 8Page: 859-860KeywordsBlood flowDiureticsDrugsGlucoseGlucose intoleranceGlucose toleranceInsulin secretionMusclesType 2 diabetes ePublished: 15 August 2000 Issue Published: 15 October 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Planning for Better Care Fund was a "shambles," says parliamentary committee
Authors: J. Wise
Journal: BMJ (2014)

The planning for the Better Care Fund, set up to move care out of hospitals into the community, has been a “shambles,” said Margaret Hodge, chair of the parliamentary public accounts committee, after a critical report from the National Audit Office.1

The Better Care Fund aims to deliver more joined-up local services to older and disabled people to care for them in the community and keep them out of hospital. It will pool £5.3bn (€6.8bn; $8.4bn) of existing NHS and local authority funding and will run from April 2015. Local health and wellbeing boards had to submit their plans in April 2014 for how they would spend their fund …
Relation of Diet to High-Density-Lipoprotein Cholesterol in Middle-Aged Marathon Runners, Joggers, and Inactive Men
Authors: G. Harley Hartung, John P. Foreyt, Robert E. Mitchell, Imogene Vlasek, Antonio M. Gotto
Journal: New England Journal of Medicine (1980)

We investigated the effect of diet on high-density-lipoprotein (HDL) cholesterol in 59 healthy middle-aged marathon runners, 85 joggers, and 74 inactive men. Marathon runners and joggers reported eating less red meat (P less than 0.0001), bacon (P less than 0.05), and sausage (P less than 0.01) than did the inactive men, although meat consumption was not significantly correlated with HDL. Results suggest that HDL differences (marathon runners, 65 mg per deciliter; joggers, 58 mg per deciliter; inactive men, 43 mg per deciliter) among the three groups were primarily the result of distance run, not dietary factors. Distance run was also the best predictor of the HDL:total cholesterol ratio and of total cholesterol (a negative correlation), and it was second only to weight in predicting triglyceride levels.
A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum eosinophilic cationic protein (ECP), soluble interleukin 2 receptor (sIL-2R), IL-4, and soluble intercellular adhesion molecule 1 (sICAM-1) in children with asthma
Authors: Iwona Stelmach, Joanna Jerzynska, Piotr Kuna
Journal: Journal of Allergy and Clinical Immunology (2002)
He Learns to Care
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2013)

Ad LibitumDecember 3, 2013He Learns to CareJack Coulehan, MD, MPHJack Coulehan, MD, MPHFrom Setauket, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-11-201312030-00015 Audio Reading - “He Learns to Care” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "He Learns to Care," by J. Coulehan. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail that ... Author, Article, and Disclosure InformationAffiliations: From Setauket, New York.Current Author Address: Jack Coulehan, MD, MPH, e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “He Learns to Care” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "He Learns to Care," by J. Coulehan. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics December 3, 2013Volume 159, Issue 11Page: 788KeywordsAddictsFatigueHeadachesLiverMemoryPatients ePublished: 3 December 2013 Issue Published: December 3, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Immune-Complex Arthritis in Viral Hepatitis?
Authors: Raymond S. Koff
Journal: New England Journal of Medicine (1971)

Joint involvement is now a well recognized complication of systemic infections produced by both RNA (e.g., rubella or mumps) and DNA (e.g., vaccinia or variola) viruses.1 Although arthralgia is a common prodromal symptom in both virus A (short-incubation) and virus B (long-incubation) hepatitis,2 a frank polyarthritis with soft-tissue swelling, warmth and tenderness has also been described typically but not exclusively during the prodrome of virus B hepatitis, and less frequently in virus A hepatitis.2,3 Acute, self-limited, and usually symmetrical, this hepatitis-induced polyarthritis is often associated with urticaria, and occasionally with angioneurotic edema. The distal joints of the extremities are commonly . . .
Genetic manipulation of AML1-ETO–induced expansion of hematopoietic precursors in a Drosophila model
Authors: Sergey A. Sinenko, Tony Hung, Tatiana Moroz, Quynh-Minh Tran, Sohrab Sidhu, Matthew D. Cheney, Nancy A. Speck, Utpal Banerjee
Journal: Blood (2010)

Among mutations in human Runx1/AML1 transcription factors, the t(8;21)(q22;q22) genomic translocation that creates an AML1-ETO fusion protein is implicated in etiology of the acute myeloid leukemia. To identify genes and components associated with this oncogene we used Drosophila as a genetic model. Expression of AML1-ETO caused an expansion of hematopoietic precursors in Drosophila, which expressed high levels of reactive oxygen species (ROS). Mutations in functional domains of the fusion protein suppress the proliferative phenotype. In a genetic screen, we found that inactivation of EcRB1 or activation of Foxo and superoxide dismutase-2 (SOD2) suppress the AML1-ETO-induced phenotype by reducing ROS expression in the precursor cells. Our studies indicate that ROS is a signaling factor promoting maintenance of normal as well as the aberrant myeloid precursors and suggests the importance of antioxidant enzymes and their regulators as targets for further study in the context of leukemia.
952. Human Mesenchymal Stem Cells Migrate to Colon Cancer Xenografts: Potential Carriers of Cancer Therapeutics
Authors: Steven P. Zielske, Theodore S. Lawrence
Journal: Molecular Therapy (2006)

Mesenchymal stem cells (MSC) are found in the bone marrow and give rise to adipocytes, osteocytes, chondrocytes, and potentially other tissues. It has recently been shown that MSCs have affinity for lung and glioma tumors in xenograft models. We investigated MSC migration to colon cancer xenografts in conjunction with MSC transduction by a lentiviral vector as a way to deliver cancer therapeutics to the local tumor microenvironment. Subcutaneous colon or glioma tumor xenografts were generated in nude mice followed by intravenous infusion of DiOC18 fluorescently labeled MSCs. MSC pluripotentcy was confirmed by in vitro differentiation into osteocytes and adipocytes. Tumors and other organs were harvested 1 wk following MSC infusion and cryosections prepared in order to observe the presence of MSCs. We found that colon cancer tumors were selectively populated by labeled MSCs, compared to liver and spleen. MSCs were also observed to some extent in the lung. The distribution of tumor-associated MSCs were predominately at the tumor periphery and within loose clusters. In glioma xenografts, labeled MSCs were detected to a lesser extent and were mainly distributed as single cells. MSCs were then analyzed for their susceptibility to lentiviral transduction for eventual use to target cancer therapeutics to the tumor mass. We analyzed MSC transduction by a lentiviral vector harboring a luciferase-IRES-GFP cassette over a range of MOI. MSCs were easily transduced, with essentially complete transduction at an MOI of 18, and substantial transduction observed at MOIs as low as 2 when analyzed for GFP expression by flow cytometry. Luciferase expression was likewise high. These studies show that MSCs have the capacity for high lentiviral transduction and the ability to migrate to colon cancer xenografts, suggesting potential use to deliver transgene-expressed anti-cancer therapeutics to solid tumors in vivo.
Abstract 14321: Comparing Zero Coronary Artery Calcium With Other Negative Risk Factors for Coronary Heart Disease - Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Michael J Blaha, Bill McEvoy, Ron Blankstein, Matthew J Budoff, Christopher Sibley, Burke Gregory, Moyses Szklo, Roger S Blumenthal, Richard Kronmal, Khurram Nasir
Journal: Circulation (2011)

Background: Less attention is paid to negative coronary heart disease (CHD) risk factors despite their potential public health importance. With emphasis on imaging tests, whose high sensitivity mak...
Liposome concentration in canine ischemic myocardium and depolarized myocardial cells.
Authors: T M Mueller, M L Marcus, H E Mayer, J K Williams, K Hermsmeyer
Journal: Circulation Research (1981)

To determine whether liposomes (microscopic phospholipid vesicles) may be useful in delivering drugs to a region of myocardial ischemia, we studied the concentration of positively charged and neutral liposomes containing 131I-albumin and horseradish peroxidase in ischemic myocardium of 20 dogs during the first 4 hours of experimental myocardial infarction. We studied the interaction of liposomes containing fluorescent dyes and horseradish peroxidase with isolated contracting cardiac myocytes. We found that positively charged and neutral liposomes accumulated in poorly perfused myocardium and that positively charged liposomes accumulated in the ischemic region to a greater extent than neutral liposomes [138 +/- 21 vs. 81 +/- 9% (mean +/- SE) of the concentration of liposomes in uninvolved myocardium]. Electron microscopic examination of this myocardium showed liposome contents to be located in the vascular space, in endothelial cells, and in ischemic myocytes. We found high potassium environment and that liposomal contents were scattered throughout the interior of the cells in the electron micrographs of some of the isolated myocytes. Anoxia alone for 20-30 minutes did not modify the liposome-isolated myocyte interaction or cause depolarization of the cells. We conclude that liposomes may be useful as drug carriers to depolarized ischemic myocardium, although significant uptake by normal myocardial cells cannot be expected with lecithin, cholesterol, and octadecylamine liposomes we used.
Carboxyhaemoglobin and plasma thiocyanate: complementary indicators of smoking behaviour?
Authors: Y Saloojee, C J Vesey, P V Cole, M A Russell
Journal: Thorax (1982)

Carboxyhaemoglobin and plasma thiocyanate concentrations were measured in 79 non-smokers and 360 cigarette smokers. The mean levels were 0.73% and 7.09% carboxyhaemoglobin and 40 . 2 and 133 . 8 mumol thiocyanate/1 plasma respectively. With 1 . 6% carboxyhaemoglobin and 73 . 0 mumol thiocyanate/1 plasma as critical values the concentrations of carboxyhaemoglobin in 96.6% of subjects and of thiocyanate in 93.4% were compatible with reported smoking status. This difference between the two tests is significant (p less than 0 . 005). Statistical combination of the carboxyhaemoglobin and thiocyanate results, with the use of linear discrimination analysis, only marginally improved their diagnostic efficiency (96.8% of subjects were grouped correctly). This analysis did, however, successfully regroup 21 of 26 individuals with contradictory carboxyhaemoglobin and thiocyanate classifications. It is concluded that in this study determination of thiocyanate added little to the information obtained from carboxyhaemoglobin measurements alone.
THE INCIDENCE OF CANCER IN FILIPINOS
Authors: EDWARD B. VEDDER
Journal: JAMA (1927)

Hoffman,<sup>1</sup>as the result of a very extensive survey of the mortality statistics of cancer in all parts of the world, has drawn the conclusion that cancer is exceedingly rare in primitive races, and that it is a disease of civilized peoples and in a special sense is the result of present day conditions of life. This conclusion differs radically from the statements of numerous observers among various Oriental races who have found malignant tumors to be fairly common. Thus Madden,<sup>2</sup>professor of surgery at the government school of medicine at Cairo, writes: "Malignant disease among tropical and semitropical peoples, even in the black races, is much more common than is generally believed, as figures prepared for the Cancer Research Committee show. With the Oriental and tropical precocity in development, malignant disease often appears at a very early age; epithelioma of the tongue for instance at the age
Is it acceptable for people to take methylphenidate to enhance performance? Yes
Authors: J. Harris
Journal: BMJ (2009)

A drug that can improve your exam results may sound tempting, and <b>John Harris </b>believes that we should embrace its possibilities. <b>Anjan Chatterjee</b> (doi:10.1136/bmj.b1956), however, argues that the dangers have been underplayed
The other side of the coin: Intersexual selection and the expression of emotions to signal youth or maturity
Authors: George A. Lozano
Journal: Behavioral and Brain Sciences (2009)

Abstract Vigil summarizes sex-related differences in emotivity, and presents a psychological model based on the restrictive assumption that responses to stimuli are dichotomous. The model uses for support the concept of intrasexual selection, but ignores intersexual selection. An alternative hypothesis might be that emotivity signals age: maturity in men and youth in women. Integration requires considering all evolutionary biology, not just agreeable concepts.