Hypouremia in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone
Authors: Guy Decaux, Françoise Genette, Jean Mockel
Journal: Annals of Internal Medicine (1980)

Brief Reports1 November 1980Hypouremia in the Syndrome of Inappropriate Secretion of Antidiuretic HormoneGUY DECAUX, M.D., FRANÇOISE GENETTE, M.D., JEAN MOCKEL, M.D., Ph.D.GUY DECAUX, M.D.Search for more papers by this author, FRANÇOISE GENETTE, M.D.Search for more papers by this author, JEAN MOCKEL, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-5-716 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLow blood urea levels are a common finding in the syndrome of inappropriate secretion of antidiuretic hormone (1). Although they usually are attributed to body fluid dilution, some have suggested that they may also result from excessive urinary losses (2). To investigate this point we studied prospectively the relation between serum sodium levels, blood urea, and urinary urea in seven patients with the syndrome of inappropriate secretion of antidiuretic hormone. The data confirmed the suspected increase in urea urinary losses which, together with body fluid dilution, explained the low urea blood levels in our patients.Seven patients with asymptomatic hyponatremia...References1. BARTIERSCHWARTZ FW. The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med. 1967;42:790-806. CrossrefMedlineGoogle Scholar2. LEVIN L. Hyponatremic syndromes. Med Clin N Am. 1978;62:1257-72. CrossrefMedlineGoogle Scholar3. CROXTON F. Elementary Statistics with Applications in Medicine and the Biological Sciences. New York: Dover Publications; 1959. Google Scholar4. GALLAGHERSELIGSON JD. Significance of abnormally low blood urea levels. N Engl J Med. 1962;266:492-5. CrossrefMedlineGoogle Scholar5. SHANNON J. Glomerular filtration and urea excretion in relation to urine flow in the dog. Am J Physiol. 1936;117:206-25. CrossrefGoogle Scholar6. CHASISSMITH HH. The excretion of urea in normal man and in subjects with gomeruluonephritis. J Clin Invest. 1938;17:347-58. CrossrefMedlineGoogle Scholar7. MURDAUGHSCHMIDT-NIELSENDOYLEO'DELL HBER. Renal tubular regulation of urea excretion in man. J Appl Physiol. 1958;13:263-8. CrossrefMedlineGoogle Scholar8. BERLANDERSONMCDONALDSCHRIER TRKR. Clinical disorders of water metabolism. Kidney Int. 1976;10:117-32. CrossrefMedlineGoogle Scholar9. DORHOUT MEESBLOM VAN ASSENDELFNIEUWENHUIS ETM. Elevation of uric acid clearance caused by inappropriate antidiuretic hormone secretion. Acta Med Scand. 1971;189:69-72. CrossrefMedlineGoogle Scholar10. BECK L. Hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone. N Engl J Med. 1979;301:528-30. CrossrefMedlineGoogle Scholar This content is PDF only. 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Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHypertonic saline, isotonic saline, water restriction, long loops diuretics, urea or vaptans to treat hyponatremiaApproach to and management of abnormalities in plasma sodiumFluid and Electrolyte BalanceRapidity of Correction of Hyponatremia Due to Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following TolvaptanMild water restriction with or without urea for the longterm treatment of syndrome of inappropriate antidiuretic hormone secretion (SIADH): Can urine osmolality help the choice?The Posterior PituitaryTolvaptan for hyponatremia with preserved sodium pool in critically ill patientsExternal Balance of Electrolytes and Acids and AlkaliFluid and Electrolyte BalanceThe Posterior PituitaryThe Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)Clinical Laboratory Evaluation of the Syndrome of Inappropriate Secretion of Antidiuretic HormoneAge-Related Increase in Plasma Urea Level and Decrease in Fractional Urea Excretion: Clinical Application in the Syndrome of Inappropriate Secretion of Antidiuretic HormoneDifference in solute excretion during correction of hyponatremic patients with cirrhosis or syndrome of inappropriate secretion of antidiuretic hormone by oral vasopressin V2 receptor antagonist VPA-985Evidence that chronicity of hyponatremia contributes to the high urate clearance observed in the syndrome of inappropriate antidiuretic hormone secretionCombined fractional excretion of sodium and urea better predicts response to saline in hyponatremia than do usual clinical and biochemical parameters8 Hyponatraemia in AIDSRaised urea clearance in cirrhotic patients with high uric acid clearance is related to low salt excretion.The Electrolytes in HyponatremiaDrug-Induced Syndrome of Inappropriate Secretion of Antidiuretic HormoneDisorders of Antidiuretic HormoneNatriuresis and atrial natriuretic factor secretion during inappropriate antidiuresisThe Effects of Alcohol on Renal Function and ExcretionCirrhotic Ascites Pathophysiology, Diagnosis, and ManagementVlTO K. ROCCO, M.D., ATHOL J. WARE, M.D.High Plasma Levels of Atrial Natriuretic Factor in SIADHElectrolytes, BUN, creatinine: Who's at risk?Demeclocycline-Induced Phosphate Diabetes in Patients with Inappropriate Secretion of Antidiuretic HormoneHigh uric acid and urea clearance in cirrhosis secondary to increased “effective vascular volume”Diagnostic strategies in disorders of fluid, electrolyte and acid-base homeostasisUrea for long-term treatment of syndrome of inappropriate secretion of antidiuretic hormone. 1 November 1980Volume 93, Issue 5Page: 716-717KeywordsAntidiuretic hormoneBloodBody fluidsHyponatremiaPatientsSodiumUrea Issue Published: 1 November 1980 PDF DownloadLoading ...