Indirect Tests to Detect the Non-A, Non-B Hepatitis Carrier State
Authors: Harvey J. Alter, Paul V. Holland
Journal: Annals of Internal Medicine (1984)

Editorials1 December 1984Indirect Tests to Detect the Non-A, Non-B Hepatitis Carrier StateHARVEY J. ALTER, M.D., PAUL V. HOLLAND, M.D.HARVEY J. ALTER, M.D.Search for more papers by this author, PAUL V. HOLLAND, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-6-859 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElsewhere in this issue, Stevens and associates (1) have detailed the second major finding of the Transfusion-Transmitted Viruses (TTV) Study, showing a significant correlation between the presence of antibody to the hepatitis B core antigen (anti-HBc) in donors, and the occurrence of non-A, non-B hepatitis in recipients of their blood. Previously, the TTV study had shown a similar correlation between donor alanine aminotransferase (ALT) and recipient hepatitis (2).The TTV study was a superbly conducted, controlled, prospective study of transfusion-associated hepatitis. The criteria for assessing hepatitis were valid and patient follow-up was excellent. As a result, the data...References1. STEVENSAACHHOLLINGER CRF. Hepatitis B virus antibody in blood donors and the occurrence of non-A, non-B hepatitis in transfusion recipients: an analysis of the Transfusion-Transmitted Viruses Study. Ann Intern Med. 1984;101:733-8. LinkGoogle Scholar2. AACHSZMUNESSMOSLEY RWJ. Serum alanine aminotransferase of donors in relation to the risk of non-A, non-B hepatitis inrecipients: the Transfusion-Transmitted Viruses Study. N Engl J Med. 1981;304:989-94. CrossrefMedlineGoogle Scholar3. GOCKEPANICK DJ. Transfusion of blood containing anti-HBAg. In: VYAS GN, PERKINS HA, SCHMID R, eds. Hepatitis and Transfusion. New York: Grune and Stratton; 1972:319-22. Google Scholar4. HOLLINGERWERCHMELNICK FJJ. A prospective study indicating that double-antibody radioimmunoassay reduces the incidence of post-transfusion hepatitis B. N Engl J Med. 1974;290:1104-9. CrossrefMedlineGoogle Scholar5. AACHALTERHOLLINGER RHF. Risk of transfusing blood containing antibody to hepatitis-B surface antigen. Lancet. 1974;2:190-3. CrossrefMedlineGoogle Scholar6. WANDSLIEBERMANMUCHMOREISSELBACHERSHAFRITZ JHEKD. Detection and transmission in chimpanzees of hepatitis B virus-related agents formerly designated "non-A, non-B" hepatitis. Proc Natl Acad Sci USA. 1982;79:7552-6. CrossrefMedlineGoogle Scholar7. KOZIOLHOLLANDALLINGALTER DPDH. Donor antibody to hepatitis B core antigen (anti-HBc) and recipient hepatitis. In: VYAS GN, DIENSTAG JL, HOOFNAGLE JH, eds. Viral Hepatitis and Liver Disease. Orlando, Florida: Grune and Stratton, Inc.; 1984:640. Google Scholar8. HOOFNAGLEALTER JH. Chronic viral hepatitis. In: VYAS GN, DIENSTAG JL, HOOFNAGLE JH, eds. Viral Hepatitis and Liver Disease. Orlando, Florida: Grune and Stratton, Inc.; 1984:97-113. Google Scholar9. ALTER H. Posttransfusion hepatitis: clinical features risk and donor testing. In: BARKER LF, DODD RY, eds. Infection, Immunity and Blood Transfusion: Proceedings of the XVI Red Cross Scientific Symposium. New York: Allen R. Liss, Inc. (In press). Google Scholar10. SETOCOLEMANIWARSONGERETY BWSR. Detection of reverse transcriptase activity in association with the non-A, non-B hepatitis agent(s). Lancet. 1984;2:941-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARVEY J. ALTER, M.D.; PAUL V. HOLLAND, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatitis CThe Safety of Blood Components and DerivativesHazards of Blood TransfusionInfectious complications of blood transfusionRationale for Surrogate Testing to Detect Non-A, Non-B HepatitisPost-Transfusion Non-A, Non-B Hepatitis: Significance of Raised ALT and Anti-HBc in Blood DonorsOpportunities for Biotechnology in Transfusion MedicineHepatitis in household contacts of patients with hemophilia who have received multiple transfusionsAntibody to Hepatitis B Core Antigen as a Paradoxical Marker for Non-A, Non-B Hepatitis Agents in Donated BloodDELORIS E. KOZIOL, MT., PAUL V. HOLLAND, M.D., DAVID W. ALLING, M.D., JACQUELINE C. MELPOLDER, M.T., RACHEL E. SOLOMON, M.H.S., ROBERT H. PURCELL, M.D., LENITA M. HUDSON, M.T., FRANCES J. SHOUP, R.N., HENRY KRAKAUER, M.D., HARVEY J. ALTER, M.D.Hepatitis in clinical practiceSouthwestern Internal Medicine Conference: The Current Status of Non-A, Non-B Viral Hepatitis 1 December 1984Volume 101, Issue 6Page: 859-861KeywordsAlanine aminotransferaseAntigensBlood banksHematologic testsHepatitisHepatitis AHepatitis A virusHepatitis BProspective studies ePublished: 1 December 2008 Issue Published: 1 December 1984 PDF downloadLoading ...