Indomethacin-Induced Rises in Blood Pressure
Authors: JOHN G. GERBER
Journal: Annals of Internal Medicine (1983)

Editorials1 October 1983Indomethacin-Induced Rises in Blood PressureJOHN G. GERBER, M.D.JOHN G. GERBER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-4-555 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhether prostaglandins have any role in the control of blood pressure is an issue that has been debated for many years. Ever since the isolation from the renal medulla of lipid-soluble vasodepressor substances that have properties similar to the then recently discovered prostaglandins, it has been suggested that renal prostaglandins may have a physiologically important antihypertensive effect (1, 2). The isolation of prostaglandin A2from rabbit kidney medulla and the subsequent demonstration of the antihypertensive effect of intravenously administered prostaglandin A1in humans seemed to corroborate a proposed role for prostaglandin A as a circulating vasodepressor substance responsible for lowering...References1. MUIRHEAD E, JONES F, and STIRMAN J. Antihypertensive property in renoprival hypertension of extract from renal medulla. J Lab Clin Med. 1960;56:167-80. MedlineGoogle Scholar2. HICKLER R, LAULER D, SARAVIS C, VAGNUCCI A, STEINER G, and THORN G. Vasodepressor lipid from the renal medulla. Can Med Assoc J. 1964;90:280-7. MedlineGoogle Scholar3. LEE J, COVINO B, TAKMAN B, and SMITH E. Renomedullary vasodepressor substance: medullin. Circ Res. 1965;17:57-77. CrossrefMedlineGoogle Scholar4. LEE J, CROWSHAW K, TAKMAN B, and ATTREP K. The identification of prostaglandins E2, F2a, and A2 from rabbit kidney medulla. Biochem J. 1967;105:1251-60. CrossrefMedlineGoogle Scholar5. LEE J, MCGIFF J, KANNEGIESSER H, AYKENT Y, MUDD J, and FRAWLEY T. Prostaglandin A1: antihypertensive and renal effects: studies in patients with essential hypertension. Ann Intern Med. 1971;74:703-10. LinkGoogle Scholar6. ZUSMAN R, SPECTOR D, CALDWELL B, SPEROFF L, SCHNEIDER G, and MULBOW P. The effect of chronic sodium loading and sodium restriction on plasma prostaglandin A, E, and F concentrations in normal humans. J Clin Invest. 1973;52:1093-8. CrossrefMedlineGoogle Scholar7. FRÖLICH J, SWEETMAN B, CARR K, HOLLIFIELD J, and OATES J. Assessment of the levels of PGA2 in human plasma by gas chromatography-mass spectrometry. Prostaglandins. 1975;10:185-95. CrossrefMedlineGoogle Scholar8. VANE J. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature. 1971;231:232-5. CrossrefGoogle Scholar9. FITZGERALD G, BRASH A, FALARDEAU P, and OATES J. Estimated rate of prostacyclin secretion into the circulation of normal men. J Clin Invest. 1981;68:1272-5. CrossrefMedlineGoogle Scholar10. NEGUS P, TANNEN R, and DUNN M. Indomethacin potentiates the vasoconstrictor actions of angiotensin II in normal man. Prostaglandins. 1976;12:175-80. CrossrefMedlineGoogle Scholar11. SPENGLER U, LORENZ R, and WEBER P. Effects of indomethacin or ω-3 polyunsaturated fatty acids on blood pressure, pressor response and levels of vasoactive hormones [Abstract]. In: Proceedings of the V International Conference on Prostaglandins. Florence, Italy; 1982:696. Google Scholar12. HEDQVIST P. Effects of prostaglandins on autonomic transmission. In: KARIM SM, ed. Advances in Prostaglandin Research. Prostaglandins: Physiological, Pharmacological and Pathological Aspects. Lancaster, England: MTP Press Ltd.; 1976:37-61. Google Scholar13. GERBER J, OLSON R, and NIES A. Interrelationship between prostaglandins and renin release. Kidney Int. 1981;19:816-21. CrossrefMedlineGoogle Scholar14. FRÖLICH J, HOLLIFIELD J, and DORMOIS J. Suppression of plasma renin activity by indomethacin in man. Circ Res. 1976;39:447-52. CrossrefMedlineGoogle Scholar15. FRÖLICH J, HOLLIFIELD J, and MICHELAKIS A. Reduction of plasma renin activity by inhibition of fatty acid cyclooxygenase in human subjects: independence of sodium rentention. Circ Res. 1979;44:781-7. CrossrefMedlineGoogle Scholar16. SCHRÖR K and MONCADA S. Effects of prostacyclin on coronary circulation, heart rate and myocardial contractile force in isolated hearts of guinea pig and rabbit—comparison with prostaglandin E2. Prostaglandins. 1979;17:367-73. CrossrefMedlineGoogle Scholar17. GUYTON A, COLEMAN T, COWLEY A, MANNING R, NORMAN R, and FERGUSON J. A systems analysis approach to understanding long range arterial blood pressure control and hypertension. Circ Res. 1974;35:159-76. CrossrefGoogle Scholar18. GERBER J, ANDERSON R, SCHRIER R, and NIES A. Prostaglandins and the regulation of renal circulation and function. In: OATES JA, ed. Advances in Prostaglandin, Thromboxane and Leukotriene Research, Volume 10: Prostaglandins and the Cardiovascular System. New York: Raven Press; 1982:227-54. Google Scholar19. STOKES J. Effect of prostaglandin E2 on chloride transport across the rabbit thick ascending limb of Henle: selective inhibitions of the medullary portion. J Clin Invest. 1979;64:495-502. CrossrefMedlineGoogle Scholar20. KAOJARERN S, CHENNAVASIN P, ANDERSON S, and BRATER D. Nephron site of effect of nonsteroidal anti-inflammatory drugs on solute excretion in humans. Am J Physiol. 1983;244:F134-9. MedlineGoogle Scholar21. COX J, RUTECKI G, FRANCISCO L, and FERRIS T. Studies of the effects of essential fatty acid deficiency in the rat. Circ Res. 1982;51:694-702. CrossrefMedlineGoogle Scholar22. PATAK R, MOOKERJEE B, BENTZEL C, HYSERT P, BABEJ M, and LEE J. Antagonism of the effects of furosemide by indomethacin in normal and hypertensive man. Prostaglandins. 1975;10:649-59. CrossrefMedlineGoogle Scholar23. WENNMALM #. Influence of indomethacin on the systemic and pulmonary vascular resistance in man. Clin Sci Mol Med. 1978;54:141-5. MedlineGoogle Scholar24. FRIEDMAN P, BROWN E, and GUNTHER S. Coronary vasoconstrictor effect of indomethacin in patients with coronary-artery disease. N Engl J Med. 1981;305:1171-5. CrossrefMedlineGoogle Scholar25. MILLS E, WHITWORTH J, ANDREWS J, and KINCAID-SMITH P. Non-steroidal antiinflammatory drugs and blood pressure. Aust NZ J Med. 1982;12:478-82. CrossrefMedlineGoogle Scholar26. GÜLLNER H, GILL J, BARTTER F, and DUSING R. The role of the prostaglandin system in the regulation of renal function in normal women. Am J Med. 1980;69:718-24. CrossrefMedlineGoogle Scholar27. LOPEZ-OVEJERO J, WEBER M, DRAYER J, SEALEY J, and LARAGH J. Effects of indomethacin alone and during diuretic or β-adrenoceptor blockade therapy on blood pressure and the renin system in essential hypertension. Clin Sci Mol Med. 1978;55(suppl 4):203s-5s. Google Scholar28. DE JONG P, DONKER A, VAN DER WALL E, ERKELENS D, VAN DER HEM G, and DOORENBOS H. Effect of indomethacin in two siblings with a renin-dependent hypertension, hyperaldosteronism and hypokalemia. Nephron. 1980;25:47-52. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN G. GERBER, M.D.Affiliations: University of Colorado Health Sciences Center Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMinimizing Cardiovascular Complications During the Treatment of OsteoarthritisEffect of indomethacin on the antihypertensive efficacy of valsartan and lisinopril: a multicentre studyElevation of blood pressure by genetic and pharmacological disruption of the ET B receptor in miceEffect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the ratEffect of Aspirin on Central and Peripheral Cardiovascular Adaptation to Exercise in Heart Failure: Participation of Splanchnic FlowHemodynamic and Humoral Effects of Low-Dose Aspirin in Treated and Untreated Essential Hypertensive PatientsRenal complications of nonsteroidal anti-inflammatory drugsEffect of Naproxen and Sulindac on Blood Pressure Response to AtenololNonsteroidal Anti-Inflammatory Drugs, and HypertensionEldad S. Kisch, MD, PhD, Benno Fischel, MD, Michael Yaron, MDRapid antidepressant response to alprazolam in depressed patients with high catecholamine output and heterologous desensitization of platelet adenylate cyclaseTherapeutic Interventions in the Treatment of Acute and Chronic Pain in OsteoarthrosisThe Effect Of Indomethacin On Cerebral Blood-Flow Velocity In Premature InfantsIbuprofen Interferes with the Efficacy of Antihypertensive Drugs A Randomized, Double-Blind, Placebo-Controlled Trial of Ibuprofen Compared with AcetaminophenKENNETH L RADACK, M.D., COLLEEN C. DECK, Pharm.D., SAUL S. BLOOMFIELD, M.D.The influence of ibuprofen, diclofenac and sulindac on the blood pressure lowering effect of hydrochlorothiazideHypercholesterolemic effect of indomethacin in the ratINTERACTIONS BETWEEN NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND ANTIHYPERTENSIVES AND DIURETICSEFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON CONTROL OF HYPERTENSION BY BETA-BLOCKERS AND DIURETICSTissue HormonesThe arthritic patient with hypertension: Selection of an NSAIDThe Role of Prostaglandins in Human HypertensionAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and goutProstaglandins and Blood PressureHANS-GEORG GÜLLNER, M.D. 1 October 1983Volume 99, Issue 4 Page: 555-558 Keywords Blood pressure Prostaglandins Rabbits Renal circulation ePublished: 1 December 2008 Issue Published: 1 October 1983 PDF downloadLoading ...