Hepatitis B Prevention and Human Immunodeficiency Virus (HIV) Infection
Authors: Stephen C. Hadler
Journal: Annals of Internal Medicine (1988)

Editorials15 July 1988Hepatitis B Prevention and Human Immunodeficiency Virus (HIV) InfectionStephen C. Hadler, MDStephen C. Hadler, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-2-92 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHepatitis B virus (HBV) infection has been a well-defined problem among homosexual men and parenteral drug abusers for almost 20 years (1-3). Homosexual men were a willing and reliable high-risk population for the initial studies of hepatitis B vaccine efficacy and, more recently, for studies of the vaccine's long-term protection (4, 5). Unfortunately, during the last 6 years, programs to provide vaccine to these groups have largely foundered due to high cost, lack of awareness of risk and motivation to receive vaccine, lack of third-party payment despite demonstrated cost effectiveness, and, perhaps, a low priority for hepatitis B vaccination in...References1. CherubinHargrovePrince CAA. The serum hepatitis related antigen (SH) in illicit drug users. Am J Epidemiol. 1970;91:510-17. CrossrefMedlineGoogle Scholar2. SchreederThompsonHadler MSS. Hepatitis B in homosexual men: prevalence of infection and factors related to transmission. J Infect Dis. 1982; 146:7-15. CrossrefMedlineGoogle Scholar3. SzmunessMuchPrince WMA. On the role of sexual behavior in the spread of hepatitis B infection. Ann Intern Med. 1975;83:489-95. LinkGoogle Scholar4. SzmunessStevensHarley WCE. Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States. N Engl J Med. 1980;303:833-41. CrossrefMedlineGoogle Scholar5. HadlerFrancisMaynard SDJ. Long-term immunogenicity and efficacy of hepatitis B vaccine in homosexual men. N Engl J Med. 1986;315:209-14. CrossrefMedlineGoogle Scholar6. . Update on hepatitis B prevention. MMWR. 1987;36:353-60, 366. MedlineGoogle Scholar7. CollierCoreyMurphyHandsfield ALVH. Antibody to human immunodeficiency virus and suboptimal response to hepatitis B vaccination. Ann Intern Med. 1988;109:101-5. LinkGoogle Scholar8. CarneWellerWaite CIJ. Impaired responsiveness of homosexual men with HIV antibodies to plasma derived hepatitis B vaccine. Br Med J. 1987;294:866-8. CrossrefMedlineGoogle Scholar9. DrakeParmleyBritton JRH. Loss of hepatitis B antibody in human immunodeficiency virus-positive hemophilia patients. Pediatr Infect Dis J. 1987;6:1051-4. CrossrefMedlineGoogle Scholar10. HadlerJudsonEchenberg SFD. Effect of prior human immunodeficiency virus infection on the outcome of hepatitis B virus infection [Abstract]. J Med Virol. 1987;21:87A. Google Scholar11. McLeanShaw AR. Hepatitis B virus vaccine [Letter]. Ann Intern Med. 1982;97:451. LinkGoogle Scholar12. TaylorStevensRodriguez de CordobaRubenstein PCSP. Hepatitis B virus and human immunodeficiency virus: possible interactions In: Zuckerman AJ, ed. Viral Hepatitis and Liver Disease. New York: Alan R. Liss, Inc. 1988; 198-200. Google Scholar13. SolomonKaslowPhair RRJ. Human immunodeficiency virus and hepatitis delta virus in homosexual men: a study of four cohorts. Ann Intern Med. 1988;108:51-4. LinkGoogle Scholar14. Human immunodeficiency virus infection in the United States: a review of current knowledge. MMWR. 1987;36(Suppl 6):2-3, 23-6. Google Scholar15. Recommendations for protection against viral hepatitis. MMWR. 1985;34:313-24, 329-35. MedlineGoogle Scholar16. PerrilloRegensteinRoodman RFS. Chronic hepatitis B in asymptomatic homosexual men with antibody to the human immunodeficiency virus. Ann Intern Med. 1986;105:382-3. LinkGoogle Scholar17. KrogsgaardLindhardtNielson KBJ. The influence of HTLV-III infection on the natural history of hepatitis B virus infection in male homosexual HBsAg carriers. Hepatology. 1987;7:37-41. CrossrefMedlineGoogle Scholar18. Self-reported behavioral change among gay and bisexual men—San Francisco. MMWR. 1985;34:613-5. MedlineGoogle Scholar19. Changing patterns of groups at high risk for hepatitis B in the United States. MMWR. 1988;[In press]. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. 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Peter Parsa, MDAIDS and the gastroenterologistAIDS and the gastroenterologistVaccination against hepatitis B in homosexual menFactors influencing the immune response to hepatitis B vaccine, booster dose guidelines, and vaccine protocol recommendationsIs booster injection with hepatitis B vaccine necessary in healthy responders? 15 July 1988Volume 109, Issue 2Page: 92-94KeywordsAddictsHIVHIV infectionsHepatitis AHepatitis BHepatitis B virusHomosexualsMotivationVaccines Issue Published: 15 July 1988 PDF DownloadLoading ...