tbuckley/cabot-search huggingface dataset:
In Memoriam: Pentti K. Siiteri, Ph.D. Editor-in-Chief, Endocrine Reviews, 1985–1990
Authors: Robert B. Jaffe
Journal: Endocrine Reviews (2012)

Pentti Siiteri was a brilliant, inquisitive, and outstanding scientist, who delved deeply to get to the core of very significant, important, and novel hormonal findings, no matter how complex the issues. He did not stop digging regardless of how complex the issue, and his investigations were almost always well thought through, and almost always correct.

“Finn,” which was what almost everybody called him, had a love and enjoyment of life in general, and science particularly.

He had five delightful children, four sons and one daughter, all of whom were extremely fond of their Dad. His delightful wife, Helen, is a successful and perceptive writer of children's books, and a thoughtful, intelligent, charming woman and mother.

Among Finn's numerous discoveries were demonstrations of key facets of the human placenta, the early studies of progesterone and estrogens, both physiologically and pathologically, and various forms of cancer.

He completed his doctorate at Dartmouth and a postdoctoral fellowship at Columbia University. He studied with the brilliant, perceptive, world-renowned biochemist, Seymour Lieberman, who trained many outstanding biochemists.

When Finn was at Columbia University, he also worked closely with Paul MacDonald, a brilliant physician-scientist. Soon after Paul moved back to the University of Texas Southwestern in Dallas from Columbia, Finn joined him in Dallas. They produced a series of very important studies concerning the placenta and free and conjugated steroids, for which Finn was well known and received many honors, including a major formal presentation in Finland.

Shortly after I joined the faculty at the University of California, San Francisco, and established the Center for Reproductive Medicine and Biology to enhance basic science in Obstetrics and Gynecology. I was invited to speak at the University of Texas Southwestern, where Finn had been successful and productive for many years. I was looking for a senior biochemist who could help nurture and train more junior physicians and scientists. Finn accepted my offer and soon joined me on the faculty of UCSF in the Center for Reproductive Medicine and Biology, where he had a fruitful scientific career. With Finn as a senior faculty member, we recruited a panoply of talented faculty members, fellows, and graduate students.

Aside from his scientific talents, one of Finn's many other abilities included playing a variety of string instruments, including a mandolin, guitar, and ukulele. He often serenaded us with his ukulele and other instruments.

Finn was a warm, caring, unique, and wonderful individual. He was one of a kind, and will be missed by family, friends, and colleagues.
Gene Expression Profiling Predicts Survival in Conventional Renal Cell Carcinoma
Authors: Hongjuan Zhao, Börje Ljungberg, Kjell Grankvist, Torgny Rasmuson, Robert Tibshirani, James D Brooks
Journal: PLoS Medicine (2005)

Conventional renal cell carcinoma (cRCC) accounts for most of the deaths due to kidney cancer. Tumor stage, grade, and patient performance status are used currently to predict survival after surgery. Our goal was to identify gene expression features, using comprehensive gene expression profiling, that correlate with survival.Gene expression profiles were determined in 177 primary cRCCs using DNA microarrays. Unsupervised hierarchical clustering analysis segregated cRCC into five gene expression subgroups. Expression subgroup was correlated with survival in long-term follow-up and was independent of grade, stage, and performance status. The tumors were then divided evenly into training and test sets that were balanced for grade, stage, performance status, and length of follow-up. A semisupervised learning algorithm (supervised principal components analysis) was applied to identify transcripts whose expression was associated with survival in the training set, and the performance of this gene expression-based survival predictor was assessed using the test set. With this method, we identified 259 genes that accurately predicted disease-specific survival among patients in the independent validation group (p < 0.001). In multivariate analysis, the gene expression predictor was a strong predictor of survival independent of tumor stage, grade, and performance status (p < 0.001).cRCC displays molecular heterogeneity and can be separated into gene expression subgroups that correlate with survival after surgery. We have identified a set of 259 genes that predict survival after surgery independent of clinical prognostic factors.
What the fetus feels.
Authors: H B Valman, J F Pearson
Journal: BMJ (1980)

The fetus's environment is disturbed by sounds, light, and touch and he responds to these disturbances by moving.Until the late nineteenth century babies were thought to be born deaf as well as dumb.In fact the inner ear of the fetus is completely developed by mid-pregnancy, and the fetus responds to a wide variety of sounds.He is surrounded by a constant very loud noise in the uterus-the rhythmical sound of the uterine blood supply punctuated by the noises of air passing through the mother's intestine.Loud noises from outside the uterus such as the slamming of a door or loud music reach the fetus and he reacts to them.The fetus also responds to sounds in frequencies so high or low that they cannot be heard by the human adult ear, which suggests that sensory pathways other than the ear are implicated.Movements of the fetus tend to be inhibited by low frequencies and increased by high frequencies.Doppler ultrasound used for monitoring fetal heart rate appears to provoke fetal activity.Ultrasound used for imaging does not affect the fetus.After birth a mother tends to hold her baby on the left breast.There the infant can hear his mother's heartbeat, which provides the same type of rhythm that was present in the uterus and which appears to have a cIming effect.Recordings of the adult heartbeat or of the noise in the uterus have a vlming effect on infants when they are played to them.
Acecainide for Ventricular Arrhythmias
Authors: John K. Vyden
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I would like to comment on the MEDICAL NEWS article entitled "Alter Drug Structure-Avert Induced Lupus" (1981;246:1634) that dealt with the efficacy of acecainide hydrochloride, chemically known as<i>N</i>-acetylprocainamide, in treating ventricular arrhythmias. It was of great interest to learn about Marcus A. Reidenberg, MD, and his successful clinical experience with the product. The fact that seven of 11 patients with ventricular arrhythmias and histories of procainamide-induced lupus had no recurrence of lupus when treated with acecainide is important. Also important is the fact that two of the patients who were still experiencing the lupus syndrome at the inception of the study went into remission while they took acecainide. Also impressive was Dr Reidenberg's statement: "I think we have had some patients who have done better on [acecainide] than on any other antiarrhythmic drug." Furthermore, it is gratifying to note that Dr Reidenberg's results were confirmed
Internet-Based Self-management Plus Education Compared With Usual Care in Asthma
Authors: Victor van der Meer
Journal: Annals of Internal Medicine (2009)

Background: The Internet may support patient self-management of chronic conditions, such as asthma. Objective: To evaluate the effectiveness of Internet-based asthma self-management. Design: Randomized, controlled trial. Setting: 37 general practices and 1 academic outpatient department in the Netherlands. Patients: 200 adults with asthma who were treated with inhaled corticosteroids for 3 months or more during the previous year and had access to the Internet. Measurements: Asthma-related quality of life at 12 months (minimal clinically significant difference of 0.5 on the 7-point scale), asthma control, symptom-free days, lung function, and exacerbations. Intervention: Participants were randomly assigned by using a computer-generated permuted block scheme to Internet-based self-management (n = 101) or usual care (n = 99). The Internet-based self-management program included weekly asthma control monitoring and treatment advice, online and group education, and remote Web communications. Results: Asthma-related quality of life improved by 0.56 and 0.18 points in the Internet and usual care groups, respectively (adjusted between-group difference, 0.38 [95% CI, 0.20 to 0.56]). An improvement of 0.5 point or more occurred in 54% and 27% of Internet and usual care patients, respectively (adjusted relative risk, 2.00 [CI, 1.38 to 3.04]). Asthma control improved more in the Internet group than in the usual care group (adjusted difference, −0.47 [CI, −0.64 to −0.30]). At 12 months, 63% of Internet patients and 52% of usual care patients reported symptom-free days in the previous 2 weeks (adjusted absolute difference, 10.9% [CI, 0.05% to 21.3%]). Prebronchodilator FEV1 changed with 0.24 L and −0.01 L for Internet and usual care patients, respectively (adjusted difference, 0.25 L [CI, 0.03 to 0.46 L]). Exacerbations did not differ between groups. Limitation: The study was unblinded and lasted only 12 months. Conclusion: Internet-based self-management resulted in improvements in asthma control and lung function but did not reduce exacerbations, and improvement in asthma-related quality of life was slightly less than clinically significant. Primary Funding Source: Netherlands Organization for Health Research and Development, ZonMw, and Netherlands Asthma Foundation.
The Forehead Scar as a Literary Device
Authors: Nicole Cresce, Melissa A. Muszynski, Scott A. Norton
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Abstract 2280: Role of apoptosis signal-regulating kinase 1 in the cell apoptosis in oral leukoplakia
Authors: Xiaofei Tang, Jian-Fei Zhang, Wen-wen Niu, Min Zhang
Journal: Cancer Research (2014)

Abstract Oral leukoplakia is a common precancerous lesion. The mechanism is not clear. The aim is to investigate the roles of apoptosis signal-regulating kinase 1(ASK1) in the cell apoptosis in oral leukoplakia. Archival tissue sections of 10 oral leukoplakia,23 oral leukoplakia with mild to moderate dysplasia, 7 normal oral mucosa were detected by real time PCR and immunohistochemical staining of markers of ASK1 and p-ASK1.The cell apoptosis was detected by terminal deoxynucleotidyl transferase-mediated nucleotide shift enzyme(TdT) mediated d-UTP end labeling(TUNEL). The results showed The mRNA and protein expression of ASK1 in oral leukoplakia with mild to moderate dysplasia was higher than the normal mucosa(p&amp;lt;0.05).From oral normal mucosa to oral leukoplakia to mild to moderate dysplasia, the expression of p-ASK1 was increased with the increasing grade( p&amp;lt;0.05).The apoptosis in oral leukoplakia and mild to moderate dysplasia increased more than normal mucose(p&amp;lt;0.05). It suggests that ASK1 and p-ASK1 are positive correlation with the increased apoptosis in the development of oral leukoplakia, its related signal pathways and cascade may play an important role in the cell apoptosis in oral leukoplakia. Citation Format: Xiaofei Tang, Jian-Fei Zhang, Wen-wen Niu, Min Zhang. Role of apoptosis signal-regulating kinase 1 in the cell apoptosis in oral leukoplakia. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2280. doi:10.1158/1538-7445.AM2014-2280
EPIDEMIC ACUTE POLIOMYELITIS IN NORWAY IN THE YEARS 1903 TO 1906.RESULTS OF ANATOMIC INVESTIGATION OF NINETEEN CASES OF ACUTE POLIOMYELITIS AND KINDRED CONDITIONS.
Authors: FRANCIS HARBITZ
Journal: JAMA (1907)

There are frequent accounts in medical literature of epidemics of acute cerebrospinal meningitis. Much more rarely epidemics of acute poliomyelitis have been observed. A few such epidemics have been described, however, and apparently they occur with relative frequency in North America and the Scandinavian countries. It will be remembered that from June to August, 1894, there was an epidemic in the Otter Creek Valley in Vermont of 150 or 160 cases, which probably, at least largely, were cases of acute poliomyelitis.<sup>1</sup>A similar epidemic occurred in New York in 1899<sup>2</sup>with about 30 cases, and a third one in 1902 has been briefly described by Painter.<sup>3</sup>It involved 38 cases of acute poliomyelitis and a few cases of acute cerebrospinal meningitis. Unfortunately, there are no records of anatomic examination from these epidemics, so one can not feel certain that there were not also cases of other diseases,
Very Late Stent Thrombosis and Late Target Lesion Revascularization After Sirolimus-Eluting Stent Implantation
Authors: Takeshi Kimura, Takeshi Morimoto, Yoshihisa Nakagawa, Kazuya Kawai, Shunichi Miyazaki, Toshiya Muramatsu, Nobuo Shiode, Masanobu Namura, Takahito Sone, Shigeru Oshima, Hideo Nishikawa, Yoshikazu Hiasa, Yasuhiko Hayashi, Masakiyo Nobuyoshi, Kazuaki Mitudo
Journal: Circulation (2011)

There is a scarcity of long-term data from large-scale drug-eluting stent registries with a large enough sample to evaluate low-frequency events such as stent thrombosis (ST).Five-year outcomes were evaluated in 12 812 consecutive patients undergoing sirolimus-eluting stent (SES) implantation in the j-Cypher registry. Cumulative incidence of definite ST was low (30 day, 0.3%; 1 year, 0.6%; and 5 years, 1.6%). However, late and very late ST continued to occur without attenuation up to 5 years after sirolimus-eluting stent implantation (0.26%/y). Cumulative incidence of target lesion revascularization within the first year was low (7.3%). However, late target lesion revascularization beyond 1 year also continued to occur without attenuation up to 5 years (2.2%/y). Independent risk factors of ST were completely different according to the timing of ST onset, suggesting the presence of different pathophysiological mechanisms of ST according to the timing of ST onset: acute coronary syndrome and target of proximal left anterior descending coronary artery for early ST; side-branch stenting, diabetes mellitus, and end-stage renal disease with or without hemodialysis for late ST; and current smoking and total stent length >28 mm for very late ST. Independent risk factors of late target lesion revascularization beyond 1 year were generally similar to those risk factors identified for early target lesion revascularization.Late adverse events such as very late ST and late target lesion revascularization are continuous hazards, lasting at least up to 5 years after implantation of the first-generation drug-eluting stents (sirolimus-eluting stents), which should be the targets for developing improved coronary stents.
PROLONGED GESTATION, ACRANIA MONSTROSITY AND APPARENT PLACENTA PREVIA IN ONE OBSTETRICAL CASE.
Authors: CHARLES REA
Journal: JAMA (1898)

The following case, on account of its unique character, will probably be of interest: About the middle of April, 1897, Mrs. F., 4-para, age 34, engaged me to attend her in confinement which was expected about July 1, 1897. When questioned, she told me her last menstruation occurred September 4, 1896, but did not indulge in sexual intercourse until two days before her next expected menstrual period, or September 30, and that she had not copulated for two months before this period and not at all afterward. Accepting these statements as facts, she should have fallen in labor about July 6, 1897. On June 20, I was summoned to her on account of a "severe period" coming on. Upon arriving at her home and making careful inquiry, I was told that two months before she had passed considerable blood and each time there was very little pain. A vaginal examination
Lupus Erythematosus, Treatment?
Authors: MICHAEL D. LOCKSHIN
Journal: Annals of Internal Medicine (1973)

Letters1 June 1973Lupus Erythematosus, Treatment?MICHAEL D. LOCKSHIN, M.D., F.A.C.P.MICHAEL D. LOCKSHIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-6-969 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent publications about systemic lupus erythematosus in the ANNALS OF INTERNAL MEDICINE and elsewhere have emphasized aggressive forms of therapy for this disease (1, 2). Little emphasis has been placed on the need to fit therapy to the extent of clinical illness. In particular, little has been published about themanagement of patients who have serologic findings compatible with the diagnosis of systemic lupus erythematosus but who do not have clinically evident multisystem disease.I have seen six patients with serologically but not clinically diagnosable systemic lupus erythematosus since 1969, when the DNA-binding assay (3) was first...References1. DONADIOHOLLEYWAGONER JKR: Treatment of lupus nephritis with prednisone and combined prednisone and azathioprine. Ann Intern Med 77:829-835, 1972 LinkGoogle Scholar2. SHARONKAPLANDIAMOND EDH: Exacerbation of systemic lupus erythematosus after withdrawal of azathioprine therapy. N Engl J Med 288:122-124, 1973 CrossrefMedlineGoogle Scholar3. PINCUSSCHURROSE TPJ: Measurement of serum DNA-binding activity in systemic lupus erythematosus. N Engl J Med 281:701-705, 1969 CrossrefMedlineGoogle Scholar4. COHENCANOSO AJ: Criteria for the classification of systemic lupus erythematosus—status 1972. Arthritis Rheum 15:540-543, 1972 CrossrefMedlineGoogle Scholar5. ESTESCHRISTIAN DC: The natural history of systemic lupus erythematosus by prospective analysis. Medicine (Baltimore) 50:85-95, 1971 CrossrefMedlineGoogle Scholar6. LIGHTFOOT R: Significance of persistent serologic abnormalities in systemic lupus erythematosus (SLE) (abstract). Arthritis Rheum 15:455, 1972 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Hospital for Special Surgery New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAbsent factor II in systemic lupus erythematosus. Immunologic studies and response to corticosteroid therapy 1 June 1973Volume 78, Issue 6Page: 969-970KeywordsLupus erythematosusSystemic lupus erythematosus Issue Published: 1 June 1973 PDF DownloadLoading ...
Modified Goodell Dilator.
Authors: CHARLES F. SPANGLER
Journal: JAMA (1900)

The accompanying illustration is a modification of the Goodell dilator. This is designed chiefly for office work, and can be conveniently manipulated through an ordinary speculum without an assistant or an anesthetic. It is neat in construction, light in weight and embodies sufficient strength. It is evenly balanced and can be poised and directed with accuracy with the fingers of one hand while the other is engaged with the tenaculum. The blades are smooth, delicately curved, permitting a ready introduction and secure a dilatation of ⅞ of an inch. The body and handles occupy 50 per cent, less space than the original instrument. The degree of dilatation is ample for correcting constrictions of the cervical canal to facilitate medication of the endometrium, or for the use of the ordinary sized curettes; and precludes the danger of unnecessary tearing of the tissues of the cervix, always incident to the use of
Fibrinogen Philadelphia, a hypodysfibrinogenemia characterized by abnormal polymerization and fibrinogen hypercatabolism due to γ S378P mutation
Authors: Margaret A. Keller, Josè Martinez, Timothy C. Baradet, Chandrasekaran Nagaswami, Irina N. Chernysh, Meggin K. Borowski, Saul Surrey, John W. Weisel
Journal: Blood (2005)
Regulation of lipoprotein lipase translation by epinephrine in 3T3-L1 cells. Importance of the 3' untranslated region.
Authors: A Yukht, R C Davis, J M Ong, G Ranganathan, P A Kern
Journal: Journal of Clinical Investigation (1995)

Lipoprotein lipase (LPL) is a central enzyme in lipoprotein metabolism and is in part responsible for adipocyte lipid accumulation. Catecholamines are known to decrease the activity of LPL in adipocytes, and we have previously demonstrated that this inhibition occurs posttranscriptionally, with a prominent inhibition of LPL translation. To better characterize the inhibition of LPL translation, 3T3-L1 cells were differentiated into adipocytes, and exposed to epinephrine. Epinephrine induced a dose-dependent decrease in LPL synthesis using [35S]methionine incorporation, with no change in LPL mRNA levels, demonstrating translational regulation of LPL in this cell line. The poly A-enriched RNA from epinephrine-treated cells was translated well in vitro, and there was no difference in the polysome profiles from control and epinephrine-treated cells, suggesting that epinephrine did not affect mRNA editing, and did not induce an inhibition of translation initiation. To obtain evidence for the presence of an inhibitory factor, a cytoplasmic extract from control, and epinephrine-treated adipocytes was human. When compared to the control cell extract, the epinephrine-treated cell extract sharply inhibited LPL translation in vitro, yet had no effect on the translation of other mRNAs. Epinephrine-treated cells had fourfold more of this inhibitor activity than control cells, and this translation inhibition was partially reversed by heat treatment. To determine what region of the LPL mRNA was involved in the translation inhibition, different LPL constructs were synthesized. The inhibitory effect of the epinephrine-treated cell extract was dependent on the presence of the first 40 nucleotides of the 3' (untranslated region UTR) (nucleotides 1599-1638), whereas deletion of the 5' UTR and other areas of the 3' UTR had no effect on translation inhibition. When a sense RNA strand corresponding to this region was added to the in vitro translation reaction, it restored translation towards normal, suggesting that the sense strand was competing for a transacting binding protein. Thus, epinephrine-treated adipocytes produced a transacting factor, probably a protein, that interacted with a region on the LPL mRNA between nucleotides 1599 and 1638, resulting in an inhibition of translation. These studies add new insight into the hormonal regulation of LPL.