tbuckley/cabot-search huggingface dataset:
Effects of topical treatment with the raft modulator miltefosine and clobetasol in cutaneous mastocytosis: a randomized, double-blind, placebo-controlled trial
Authors: K. Hartmann, F. Siebenhaar, B. Belloni, K. Brockow, R. Eben, B. Hartmann, F. Ruëff, N. Schoepke, P. Staubach, A. Weber, M. Maurer
Journal: British Journal of Dermatology (2009)

Background Mastocytosis is characterized by the accumulation and activation of mast cells in different organs, most commonly the skin. Miltefosine, a raft modulator, has recently been shown to inhibit the activation of mast cells and to reduce mast cell‐driven skin inflammatory responses. Objectives To study the safety and efficacy of topical miltefosine treatment of skin lesions in patients with mastocytosis. Methods Thirty‐nine adult patients with mastocytosis with skin involvement were treated in a double‐blind, placebo‐controlled, parallel trial with topical miltefosine and clobetasol for 2 weeks. Treatment areas were analysed for changes in skin lesions and symptoms following mechanical irritation using novel volumetric imaging techniques and quantitative histomorphometry. Results Miltefosine and clobetasol failed to reduce significantly weals and flare‐type skin responses following mechanical provocation. Miltefosine showed a trend towards reducing the volume of weals. Clobetasol significantly decreased the volume of weals and the number of mast cells in the upper dermis. Treatment with miltefosine, but not with clobetasol, was often associated with eczematous skin irritation, which may, at least in part, be related to the formulation of miltefosine containing the potentially irritating alkanol propanediol as the vehicle. Conclusions Raft modulators such as miltefosine are promising candidates for novel therapeutic strategies in patients with cutaneous mastocytosis. Future studies should be performed with improved formulations using nonirritant vehicles.
Use of HMOs
Authors: Jack Shelton
Journal: JAMA (1984)

To the Editor.—  In response to the recent article, Evidence for Self-Selection Among HMO Enrollees, 1 The National Industry Council for HMO Development would like JAMA 's readers to be aware that it is addressing this issue to obtain more conclusive data.  The council comprises 35 employer, labor, financial, and health industry executives and was formed in 1978 to assist the further growth and development of health maintenance organizations. It believes that the issue of adverse selection toward any form of health plan is a serious question. In fact, the council deliberated this topic during its September 1983 meeting in Nashville. Dr Jackson-Beeck was among several persons invited to present their views.  The conclusion of the council work group on this topic is that the data thus far available are inconclusive and not sufficient for policymaking by employers and other purchasers of medical care. The survey by Jackson-Beeck and Kleinman
Association of Cytomegalovirus Infection and Penile Ulcer
Authors: I. W. Fong
Journal: Annals of Internal Medicine (1993)

Letters1 December 1993Association of Cytomegalovirus Infection and Penile UlcerI. W. Fong, MDI. W. Fong, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-11-199312010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Patients in the late stages of the acquired immunodeficiency syndrome (AIDS) often present with chorioretinitis, esophagitis, enterocolitis, hepatitis, adrenalitis, encephalitis, and occasionally pneumonitis due to cytomegalovirus (CMV) infection. I recently cared for a patient with human immunodeficiency virus (HIV) infection and a longstanding penile ulceration due to CMV infection, the first reported instance of this association.A 25-year-old black man from Guyana presented with a painless penile ulcer of 6 months' duration, a 4.5-kg weight loss, and a 2-week history of fever, chills, and malaise. The patient is heterosexual with a history of previous intravenous drug abuse. ...References1. Van der Piil JW, Frissen PH, Reiss P, Huselbosch HJ, Van den Tweel JG, Lange JM, et al. Foscarnet and penile ulceration (Letter). Lancet. 1990; 335:286. Google Scholar2. Horn TD, Hood AF. Cytomegalovirus is predictably present in perineal ulcers from immunosuppressed patients. Arch Dermatol. 1990; 126:642-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCYTOMEGALOVIRUS BALANITIS IN A RENAL TRANSPLANT RECIPIENT 1 December 1993Volume 119, Issue 11Page: 1149KeywordsAIDSCytomegalovirus infectionEnzyme linked immunosorbent assayHerpes simplexPenisPneumonitisSexually transmitted diseasesUlcersWeight lossWestern blot Issue Published: 1 December 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Treatment of relapsed blast-phase Philadelphia-chromosome-positive leukaemia after non-myeloablative stem-cell transplantation with donor lymphocytes and imatinib
Authors: Bipin N Savani, Ramaprasad Srinivasan, Igor Espinoza-Delgado, Colleen Dorrance, Yoshiyuki Takahashi, Takehito Igarashi, Katayoun Rezvani, Andreas Lundqvist, A John Barrett, Richard W Childs
Journal: The Lancet Oncology (2005)
Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties
Authors: Rachel L. Rutishauser, Gislâine A. Martins, Sergey Kalachikov, Anmol Chandele, Ian A. Parish, Eric Meffre, Joshy Jacob, Kathryn Calame, Susan M. Kaech
Journal: Immunity (2009)
Transthoracic Echocardiography Guidance for TAVR Under Monitored Anesthesia Care
Authors: Partho P. Sengupta, Brandon M. Wiley, Sandeep Basnet, Anitha Rajamanickman, Jason C. Kovacic, Gregory W. Fischer, Annapoorna S. Kini, Samin K. Sharma
Journal: JACC. Cardiovascular imaging (2015)
Case holding in patients with tuberculosis in Botswana.
Authors: J. A. Kumaresan, E. T. Maganu
Journal: BMJ (1992)

OBJECTIVE--To evaluate the effectiveness of daily supervised short course chemotherapy in a national tuberculosis programme. DESIGN--Observation of programme during 1984-90. In October 1986 short course chemotherapy was introduced with patients receiving treatment daily from staff in their nearest health facility. SETTING--Botswana national tuberculosis programme. SUBJECTS--All patients with tuberculosis. MAIN OUTCOME MEASURES--Proportions of patients complying with and defaulting from treatment (missing &gt; or = 43 days9 treatment). RESULTS--2938 cases of tuberculosis were recorded in 1990, 1528 of which were of sputum positive pulmonary disease. 2711 (92.3%) patients complied with treatment and 227 (7.7%) defaulted. Before introduction of short course chemotherapy compliance was about 60% compared with over 90% in 1987-90. CONCLUSIONS--A programme using daily supervised short course chemotherapy integrated into the primary health care system is an effective method of treating tuberculosis. The costs of the programme need to be evaluated.
Epidemiology and aetiology of basal cell carcinoma
Authors: H. Tran, K. Chen, S. Shumack
Journal: British Journal of Dermatology (2003)

Basal cell carcinoma is the most common malignancy among caucasians worldwide. Accurate epidemiological data can be difficult to obtain, but does suggest that the overall incidence is increasing. Risk factors include skin type, prior skin cancers and immunosuppression. Research in free radical‐mediated cellular injury and innate defence mechanisms, and ultraviolet radiation‐induced genetic mutations have improved our understanding of the development of this disorder.
Reduction of the Potency of Luteinizing Hormone by Estrogen
Authors: Anne W. Lucky, Robert W. Rebar, Robert L. Rosenfield, Nanette Roche-Bender, James Helke
Journal: New England Journal of Medicine (1979)

The reduction of the potency of luteinizing hormone (LH) by estrogen was investigated. The bioactive and immunoreactive forms of LH from basal and luteotropin-releasing-hormone-stimulated serum samples from 6 teen-age girls with gonadal dysgenesis before and during induction of secondary sex changes with estrogen were assayed. The 6 girls, 13-15 years of age, were feminized daily with doses of 10 or 20 mcg of oral ethinyl estradiol (EE). The girls showed satisfactory secondary sexual development, including breast development and menses, within the 1st 6 months of estrogen therapy. Both forms of LH declined with increasing dose and time of therapy. However, the ratio of the bioactive to the immunoreactive form of the hormone was significantly higher (p .001) before treatment than after 3 months of treatment with 10 mcg of EE and after 3 additional months of treatment with EE during which time the daily dose was increased to 20 mcg. 2 younger girls, ages 9 and 11, with gonadal dysgenesis showed no elevation of the immunoreactive form of the hormone, a weak response to luteotropin-releasing hormone, and a low ratio of bioactive to immunoreactive LH. These data indicate that estrogen produces qualitative and quantitative changes in serum LH in girls with gonadal dysgenesis.
Reply from Authors re: Margit M. Fisch. Validated Patient-reported Outcome Measure: A Step Forward to Improve Patient Counselling Before Urethral Reconstruction. Eur Urol 2013;64:783–4
Authors: Matthew J. Jackson, Altaf Mangera, Nick Watkin, Christopher R. Chapple, Daniela E. Andrich, Robert S. Pickard, Anthony R. Mundy
Journal: European Urology (2013)
Physician-Assisted Suicide
Authors: Paul Rousseau
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I read with interest the analysis by Mr Cotton regarding the referendum on physician-assisted suicide that recently passed in Oregon but is now pending legal disposition in the courts. The commentary was well done and equitable; however, I was dismayed at the apparent vernacular attributed to Dr Goodwin and other physicians supportive of the referendum. Dr Goodwin ostensibly stated, "Dying patients are given larger and larger doses of morphine. We talk about the 'double effect,' and know jolly well we are sedating them into oblivion, providing pain relief but also providing permanent relief, and we don't tell them."<sup>1</sup>Such a statement does a disservice to the many able and competent hospice and palliative care professionals caring for dying patients. And what this diatribe also demonstrates is that palliative care must assume importance as a respected academic discipline, similar to what has transpired in England and Canada.
Cysteinyl leukotriene expression in chronic hyperplastic sinusitis–nasal polyposis: Importance to eosinophilia and asthma
Authors: John W. Steinke, Dewayne Bradley, Pablo Arango, Charles D. Crouse, Henry Frierson, Stilianos E. Kountakis, Monica Kraft, Larry Borish
Journal: Journal of Allergy and Clinical Immunology (2003)
Postnatal physiologic hypercholemia in both premature and full-term infants.
Authors: S Barnes, G Berkowitz, B I Hirschowitz, D Wirtschafter, G Cassady
Journal: Journal of Clinical Investigation (1981)

Previous studies have shown that bile salt concentrations in human blood taken from the placenta at birth of term infants are in the range found in adults. A 125I-radioimmunoassay procedure and capillary gas liquid chromatography-mass spectrometry have been used in this investigation to measure serum bile salt concentrations in premature and normal term infants. It was found that the serum bile salt concentration in samples taken at birth in premature infants were also similar to that of adults. In the week after birth the serum bile salt concentration rose four- to sevenfold in each of the infant groups. The increase was independent of gestational age and the "health" of the child. A similar increase was observed in term infants. Thus, hypercholemia is physiologic in newborn infants. In conjunction with other abnormalities of the enterohepatic circulation of bile salts there are profound implications in the newborn for the metabolism and excretion of those endogenous and exogenous substances that are dependent on the secretion of bile salt by the liver. In addition, speculations concerning the role of parenteral nutrition in the induction of cholestasis in premature infants should be made with caution.
The Relationship to Serum Cholesterol, Triglycerides, and Hematocrit to the Thrombosis of Human Blood in Vitro.
Authors: Hyman Engelberg
Journal: Annals of Internal Medicine (1964)

s1 October 1964The Relationship to Serum Cholesterol, Triglycerides, and Hematocrit to the Thrombosis of Human Blood in Vitro.Hyman Engelberg, M.D., F.A.C.P.Hyman Engelberg, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-806_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral years ago Chandler developed a simple method for the in vitro production of thrombi using recalcified citrated whole blood. Essentially the method involves placing blood in a closed loop plastic tubing, which is then rotated at a speed approximating that of the blood flow in man. A platelet-head thrombus forms and the time it takes to do so is called the thrombus formation time. This technique lends itself well to the study of the relationship of various other circulating factors to the tendency of the blood to form a thrombus. Since the endpoint is a thrombus the method may... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Hyman Engelberg, M.D., F.A.C.P.Affiliations: Beverly Hills, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 806-806KeywordsBloodBlood flowCholesterolHematocritThrombosis ePublished: 1 December 2008 Issue Published: 1 October 1964 PDF downloadLoading ...
P319Identification of haemogenic endothelium as the main source of the blood-endothelium common lineage in the mouse embryo
Authors: L Padron-Barthe, S Temino, C Villa, L Carramolino, M Torres
Journal: Cardiovascular Research (2014)

The first endothelial and blood cells of amniote embryos appear in close association in the blood islands of the yolk sac. This association and in vitro lineage analyses have suggested a common origin from mesodermal precursors called haemangioblasts, specified in the primitive streak during gastrulation. Fate mapping and chimera studies, however, failed to provide strong evidence for a common origin in the early mouse yolk sac. Additional in vitro studies suggest instead that mesodermal precursors first generate haemogenic endothelium, which then generate blood cells in a linear sequence. We conducted an in vivo clonal analysis to determine the potential of individual cells in the mouse epiblast, primitive streak and early yolk sac. We found that early yolk sac blood and endothelial lineages mostly derive from independent epiblast populations, specified before gastrulation. Additionally, a subpopulation of the yolk sac endothelium has haemogenic activity and displays characteristics similar to those found later in the embryonic haemogenic endothelium. Our results show that the earliest endothelial and blood cell populations in the mouse embryo are specified independently, and that haemogenic endothelium first appears in the yolk sac and produces blood precursors with markers related to definitive haematopoiesis.
Evaluation of Six Methods for Estimating Synonymous and Nonsynonymous Substitution Rates
Authors: Zhang Zhang, Jun Yu
Journal: Genomics Proteomics & Bioinformatics (2006)

Abstract Methods for estimating synonymous and nonsynonymous substitution rates among protein-coding sequences adopt different mutation (substitution) models with subtle yet significant differences, which lead to different estimates of evolutionary information. Little attention has been devoted to the comparison of methods for obtaining reliable estimates since the amount of sequence variations within targeted datasets is always unpredictable. To our knowledge, there is little information available in literature about evaluation of these different methods. In this study, we compared six widely used methods and provided with evaluation results using simulated sequences. The results indicate that incorporating sequence features (such as transition/transversion bias and nucleotide/codon frequency bias) into methods could yield better performance. We recommend that conclusions related to or derived from Ka and Ks analyses should not be readily drawn only according to results from one method.
The Physician in the Hospital Organization
Authors: George Bugbee
Journal: New England Journal of Medicine (1959)

ALTHOUGH the physician is the key figure in the voluntary hospital in this country, hospital organization and administration neither reflect the doctor's actual role nor assign him a role that assures the highest possible quality of patient care. A look at the principles of organization and administration as they apply to the voluntary hospital may point the way to a better part for the physician to play — and, from that, raise the level of patient care in hospitals.In terms of organizations rather than individuals, voluntary hospitals are the principal facilities in the rendering of medical care in this . . .
Clinical course of thrombocytopenia in patients treated with imatinib mesylate for accelerated phase chronic myelogenous leukemia
Authors: Hendrik W. van Deventer, Melissa D. Hall, Robert Z. Orlowski, Beverly S. Mitchell, Lee R. Berkowitz, Cathe Hogan, Cherie H. Dunphy, Julie Koehler, Thomas C. Shea
Journal: American Journal of Hematology (2002)

Abstract We studied 28 patients with accelerated phase chronic myelogenous leukemia (CML) who were enrolled on the Novartis expanded access study 114. Diagnosis of accel‐ erated phase CML was based on karyotypic evolution (n = 9) and hematologic criteria (n = 18). All patients were begun on 600 mg/day of imatinib mesylate. Dose reductions to 400 mg/day and then 300 mg/day were prescribed for an absolute neutrophil count (ANC) of &lt;0.5/μl or a platelet count of &lt;20,000/μl. Twenty‐seven of the 28 patients continued treatment for a median of 34 weeks. Eleven patients developed thrombocytopenia following an average of 8.4 ± 1.4 weeks of therapy. The onset of thrombocytopenia was associated with disease progression in one patient and a decline in bone marrow megakaryocytes in the other 10. Nine patients recovered to a platelet count of &gt;20,000/μl after an average of 19.7 ± 1.8 weeks. Patients who developed thrombocytopenia had a longer duration of disease (9.39 vs. 4.35 years; P &lt; 0.01) and were more likely to be diagnosed with accelerated phase CML by hematologic criteria. Hematologic responses in patients with and without thrombocytopenia were comparable; however, 31.3% of patients without thrombocytopenia had a complete cytogenetic response compared to none of those with thrombocytopenia. Grade III–IV thrombocytopenia is common in accelerated phase CML and may be a marker for the inability to achieve cytogenetic response using single agent imatinib mesylate. Am. J. Hematol. 71:184–190, 2002. © 2002 Wiley‐Liss, Inc.
Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment
Authors: Joseph D. Buxbaum, Eun-Kyoung Choi, Yuxia Luo, Christina Lilliehook, Annette C. Crowley, David E. Merriam, Wilma Wasco
Journal: Nature Medicine (1998)
Association Between Prehospital Time Intervals and ST-Elevation Myocardial Infarction System Performance
Authors: Jonathan R. Studnek, Lee Garvey, Tom Blackwell, Steven Vandeventer, Steven R. Ward
Journal: Circulation (2010)

Among individuals experiencing an ST segment-elevation myocardial infarction, current guidelines recommend that the interval from first medical contact to percutaneous coronary intervention be ≤90 minutes. The objective of this study was to determine whether prehospital time intervals were associated with ST-elevation myocardial infarction system performance, defined as first medical contact to percutaneous coronary intervention.Study patients presented with an acute ST-elevation myocardial infarction diagnosed by prehospital ECG between May 2007 and March 2009. Prehospital time intervals were as follows: 9-1-1 call receipt to ambulance on scene ≤10 minutes, ambulance on scene to 12-lead ECG acquisition ≤8 minutes, on-scene time ≤15 minutes, prehospital ECG acquisition to ST-elevation myocardial infarction team notification ≤10 minutes, and scene departure to patient on cardiac catheterization laboratory table ≤30 minutes. Time intervals were derived and analyzed with descriptive statistics and logistic regression. There were 181 prehospital patients who received percutaneous coronary intervention, with 165 (91.1) having complete data. Logistic regression indicated that table time, response time, and on-scene time were the benchmark time intervals with the greatest influence on the probability of achieving percutaneous coronary intervention in ≤90 minutes. Individuals with a time from scene departure to arrival on cardiac catheterization laboratory table of ≤30 minutes were 11.1 times (3.4 to 36.0) more likely to achieve percutaneous coronary intervention in ≤90 minutes than those with extended table times.In this patient population, prehospital timing benchmarks were associated with system performance. Although meeting all 5 benchmarks may be an ideal goal, this model may be more useful for identifying areas for system improvement that will have the greatest clinical impact.
BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet
Authors: Simona Soverini, Andreas Hochhaus, Franck E. Nicolini, Franz Gruber, Thoralf Lange, Giuseppe Saglio, Fabrizio Pane, Martin C. Müller, Thomas Ernst, Gianantonio Rosti, Kimmo Porkka, Michele Baccarani, Nicholas C. P. Cross, Giovanni Martinelli
Journal: Blood (2011)
Dialogue: A Core Clinical Skill
Authors: Alan G. Pocinki
Journal: Annals of Internal Medicine (1998)

Letters1 August 1998Dialogue: A Core Clinical SkillAlan G. Pocinki, MDAlan G. Pocinki, MDWashington, DC 20037Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-3-199808010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although I share Dr. Duffy's passion for physician–patient communication, I found preposterous his suggestion that “managed care organizations that view patient satisfaction and physician satisfaction as good business” might somehow be involved in a “real push to improve physician communication” [1]. I have never worked for any such managed care organization; the organizations I have worked for care little about what is best for their patients and care not a whit about physician satisfaction.In my world, the absurdly low fees paid by managed care organizations have forced physicians to spend less and less time talking to ...References1. Duffy FD. Dialogue: the core clinical skill [Editorial]. Ann Intern Med. 1998; 128:139-41. Google Scholar Author, Article, and Disclosure InformationAffiliations: Washington, DC 20037 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPalliative care education: a global imperative 1 August 1998Volume 129, Issue 3Page: 253KeywordsHealth maintenance organizationsHeartHospitalizationsMotivationMouthPatients Issue Published: 1 August 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...