Crohn Disease and Intravenous Immunoglobulin G
Authors: Peter Knoflach
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 March 1990Crohn Disease and Intravenous Immunoglobulin GPeter Knoflach, MD, Christian Müller, MD, Martha M. Eibl, MDPeter Knoflach, MDSearch for more papers by this author, Christian Müller, MDSearch for more papers by this author, Martha M. Eibl, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-5-385 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Despite the proven effectiveness of corticosteroids in treating active Crohn disease, the search for therapeutic alternatives has continued; one of the reasons for the continuing search is the overlap of the extra-intestinal manifestations of Crohn disease with the side effects of long-term corticosteroid treatment (for example, osteoporosis). Postulating an effect on endotoxin clearance or on immunoregulation, some investigators used intravenous immunoglobulins for treating Crohn disease in two uncontrolled pilot studies (1, 2). Although some patients seemed to respond well to treatment with intravenous immunoglobulins, the numbers of patients were small, follow-up periods were short, and—most important—immunoglobulin therapy...References1. RohrKustererSchille GKM Treatment of Crohn's disease and ulcerative colitis with 7S-immunoglobulin. Lancet. 1987;1:170. CrossrefMedlineGoogle Scholar2. RaedlerLadehoffSchugGreten AESH. Adjuvante Therapie des Morbus Crohn mit IgM-angereichertem Immunglobulin. In: Deicher H, Schoeppe W, eds. Berlin: Springer Verlag; 1986:50-5. Google Scholar3. ImbachBarandund'Apuzzo PSV. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in children. Lancet. 1981;1:1228-31. CrossrefMedlineGoogle Scholar4. Stiehm E. Intravenous immunoglobulines as therapeutic agents. Ann Intern Med. 1987;107:367-82. LinkGoogle Scholar5. MeyersJanowitz SH. "Natural history" of Crohn's disease. An analytic review of the placebo lesson. Gastroenterology. 1984;87:1189-92. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Vienna Vienna, Austria A-1090 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEfficacy and Factors Associated with Treatment Response of Intravenous Immunoglobulin in Inpatients with Refractory Inflammatory Bowel DiseasesIntravenous immunoglobulin for the treatment of Crohn's diseaseBiology of Gut ImmunoglobulinsULCERATIVE PROCTITISBiology of Gut ImmunoglobulinsOral immunoglobulin treatment in Crohn's diseaseReview article: Refractory distal colitis-explanations and optionsNEW THERAPEUTIC APPROACHESImmune Modulating Therapies for Idiopathic Inflammatory Bowel DiseasesTreatment of active distal ulcerative colitis with immunoglobulin G enemasIntravenous immunoglobulins (IVIg) in the treatment of autoimmune diseases 1 March 1990Volume 112, Issue 5Page: 385-386KeywordsCorticosteroid therapyCrohn's diseaseEndotoxinsIntravenous immunoglobulinOsteoporosisPilot studies Issue Published: 1 March 1990 PDF DownloadLoading ...