tbuckley/cabot-search huggingface dataset:
Hepatitis and Leukemia
Authors: FRED ROSNER
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 May 1979Hepatitis and LeukemiaFRED ROSNER, M.D.FRED ROSNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-5-853_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Barton and Conrad suggest in the February issue (1) that hepatitis may have a beneficial effect in acute myelocytic leukemia. They postulate that hepatitis may directly suppress the leukemia or that leukemic patients with hepatitis may be those with "greater immunocompetence and thus a better prognosis." Several additional hypotheses should be considered. Patients with increased SGOT levels may not have hepatitis at all; rather their hepatocytes (and their leukemic cells) may be more sensitive to the antileukemic chemotherapy. For example, these patients may be lacking in cytarabine deaminase, thus accounting for higher and more prolonged cytarabine levels....References1. BARTON J and CONRAD M: Beneficial effects of hepatitis in patients with acute myelogenous leukemia. Ann Intern Med 90:188-190, 1979 LinkGoogle Scholar2. ROSNER F: Aplastic anemia and viral hepatitis. Lancet 2:1080, 1970 CrossrefMedlineGoogle Scholar3. HAGLER L, PASTORE R, and BERGIN J: Aplastic anemia following viral hepatitis. Report of two fatal cases and literature review. Medicine (Baltimore) 54:139-164, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRED ROSNER, M.D.Affiliations: Queens Hospital Center Affiliation of Long Island Jewish-Hillside Medical Center Jamaica, NY 11432 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byViral Hepatitis in the Compromised HostViral Hepatitis in the Compromised HostViral Hepatitis in the Compromised HostPeripheral blood remission of hairy cell leukemia after transfusion hepatitisPrognostic significance of posttransfusion hepatitis and chromosomal abnormalities in adult acute nonlymphocytic leukemiaAcute Myelogenous Leukemia and HepatitisELIO CACCIOLA, M.D., ROSARIO GLUSTOLISI, M.D. 1 May 1979Volume 90, Issue 5Page: 853-853KeywordsAcute myeloid leukemiaCellsChemotherapyHepatitisHepatitis AHepatocytesSerum glutamic oxaloacetic transaminase ePublished: 1 December 2008 Issue Published: 1 May 1979 PDF downloadLoading ...
Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.
Authors: J Sedgwick, S Brostoff, D Mason
Journal: The Journal of Experimental Medicine (1987)

One characteristic of experimental allergic encephalomyelitis (EAE) in all species is the presence of a considerable leukocyte infiltrate in the central nervous system (CNS). By adoptive transfer of EAE into irradiated or nonirradiated Lewis strain rats we now show that the bulk (greater than 90%) of infiltrating cells in the CNS are superfluous to the induction of disease, as lethally irradiated recipients, despite having very few infiltrating cells in the CNS, acquire severe paralytic EAE. The reduction in the level of infiltration in irradiated recipients is selective, however, as both irradiated and nonirradiated diseased animals have very similar numbers of cells expressing IL-2-R. Disease in irradiated recipient animals is associated with substantial submeningeal hemorrhage in the spinal cord and brain stem and similar hemorrhages are found in recipients rendered leukopenic with cytotoxic drugs. Clinical signs of disease and hemorrhage are preventable, however, by administration to the recipient rats of mAbs specific for the CD4 antigen. Classic delayed-type hypersensitivity (DTH) reactions are transferable with the same cells that produce EAE in both irradiated and nonirradiated recipient rats, but such transfer of DTH is observed only in nonirradiated recipient animals and not in irradiated rats. Collectively, the findings reported herein support the conclusion that the paralysis characteristic of acute EAE is mediated by the direct action of very small numbers of activated CD4+ lymphocytes that infiltrate the CNS and produce their effects by inducing vascular damage. The findings are not consistent with reports that the lesions in EAE are produced by a classic DTH reaction.
Abnormal Softness of the Nulliparous Uterus as a Factor in the Etiology of Uterine Distortions, and as a Cause of Impairment of Power of Locomotion
Authors: G. Hewitt
Journal: BMJ (1877)

No one who has had practical experience in the diseases peculiar to women can fail to have observed how very frequently the ability to move about, to walk, and to take exercise of various kinds, is inter- fered with in cases where some disorder of the uterus is present.
Defective insulin response of cyclic adenosine monophosphate-dependent protein kinase in insulin-resistant humans.
Authors: Y Kida, B L Nyomba, C Bogardus, D M Mott
Journal: Journal of Clinical Investigation (1991)

Insulin-stimulated glycogen synthase activity in human muscle correlates with insulin-mediated glucose disposal and is reduced in insulin-resistant subjects. Inhibition of the cyclic AMP-dependent protein kinase (A-kinase) is considered as a possible mechanism of insulin action for glycogen synthase activation. In this study, we investigated the time course of insulin action on human muscle A-kinase activity during a 2-h insulin infusion in 13 insulin-sensitive (group S) and 7 insulin-resistant subjects (group R). Muscle biopsies were obtained from quadriceps femoris muscle at times 0, 10, 20, 40, and 120 min. Insulin infusion resulted in significant inhibition of A-kinase activity at 20 and/or 40 min using 0.2, 0.6, and 1.0 microM cyclic AMP in group S. A-kinase activities both before and after insulin administration were lower in group S than in group R using 0.6 microM cyclic AMP. The decrease in apparent affinity for cyclic AMP during insulin infusion was larger for group S compared with group R. Glycogen synthase activity increased significantly after insulin infusion in both groups and was higher in group S compared with group R. The data suggest that a defective response of A-kinase to insulin in insulin-resistant subjects could contribute to their reduced insulin stimulation of skeletal muscle glycogen synthase.
Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color
Authors: Laura A.G. Armas, Susan Dowell, Mohammed Akhter, Sowjanya Duthuluru, Christopher Huerter, Bruce W. Hollis, Richard Lund, Robert P. Heaney
Journal: Journal of the American Academy of Dermatology (2007)
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
Authors: Christopher J Klein, Maria-Victoria Botuyan, Yanhong Wu, Christopher J Ward, Garth A Nicholson, Simon Hammans, Kaori Hojo, Hiromitch Yamanishi, Adam R Karpf, Douglas C Wallace, Mariella Simon, Cecilie Lander, Lisa A Boardman, Julie M Cunningham, Glenn E Smith, William J Litchy, Benjamin Boes, Elizabeth J Atkinson, Sumit Middha, P James B Dyck, Joseph E Parisi, Georges Mer, David I Smith, Peter J Dyck
Journal: Nature Genetics (2011)
A dose-dependent inhibitory effect of cyclosporine A on obliterative bronchiolitis of rat tracheal allografts.
Authors: P K Koskinen, E A Kallio, R Krebs, K B Lemström
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Inbred DA and WF rats were used as donors and recipients of heterotopic tracheal allografts. To investigate cellular and molecular mechanisms as well as inhibitory effects of differently acting immunosuppressive drugs on the development of obliterative bronchiolitis (OB), the recipient rats received either cyclosporine A (CsA; 1, 2, or 5 mg/kg/d), 15-deoxyspergualin (DSG; 1 or 2 mg/kg/d), or mycophenolate mofetil (MMF; 20 or 40 mg/kg/d), or were left without immunosuppression. The grafts were removed at various time points for histology and immunohistochemistry. In tracheal allografts removed from nonimmunosuppressed animals, respiratory epithelium was replaced by cuboidal or squamous cell epithelium, with markedly enhanced expression of epithelial major histocompatibility class (MHC) Class II antigens at 3 d after transplantation. This was associated with a pronounced inflammatory episode and proliferation of T cells and macrophages, with the prominence of lymphoid activation markers, MHC Class II antigens and interleukin-2R (IL-2R). Later, total epithelial necrosis developed and intense proliferation of granulation tissue occluded the airway lumen producing a condition resembling OB in humans. In syngeneic tracheal grafts, no such changes could be observed. CsA decreased the development of OB in a dose-dependent fashion, in association with downregulation of epithelial MHC Class II antigen expression, IL-2R expression, and the infiltration of T cells. The new immunosuppressive drugs DSG (suppression of the monocyte/macrophage action and lymphocyte proliferation) and MMF (blocking of the de novo pathway of purine synthesis), in the dose range tested, showed no significant effect on the development of OB. These results suggest that an acute alloimmune response to airway targets, perhaps to epithelium, is the primary cause of OB, since CsA, with a nearly exclusive effect on the transcription of immune cytokines, entirely inhibited the generation of OB, and that preventive intervention for OB must occur early in the T-cell activation pathway.
NEW CARDIAC ELECTRICAL BIOMAKER MEASURED ON 12-LEAD ECG STRONGLY CORRELATES WITH HIGH SENSITIVITY TROPONIN IN PATIENTS ADMITTED TO THE EMERGENCY DEPARTMENT TO RULE OUT ACUTE MYOCARDIAL ISCHEMIC INJURY
Authors: Larisa Tereshchenko, David Gatz, Randy Bell, Albert Feeny, Frederick Korley
Journal: Journal of the American College of Cardiology (2013)
Hyponatraemia in acute heart failure is a marker of increased mortality but not when associated with hyperglycaemia
Authors: Olga Milo‐Cotter, Gad Cotter, Beth D. Weatherley, Kirkwood F. Adams, Edo Kaluski, Nir Uriel, Christopher M. O'Connor, G. Michael Felker
Journal: European Journal of Heart Failure (2008)
New HIV Therapy Guidelines
Authors: Joan Stephenson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
It's Never Too Late to Stop Smoking But How Old Are Your Lungs?
Authors: Thomas L. Petty
Journal: JAMA (1993)

It is well-known that smoking is a major contributor to premature morbidity and mortality from cardiovascular diseases, lung cancer and at least six other cancers, and chronic obstructive pulmonary disease. But what is not commonly known is that pulmonary function impairment is a powerful predictor of patients at risk for premature morbidity and mortality from these smoking-related diseases. A reduced forced vital capacity, forced expiratory volume in 1 second, or both identify patients at increased risk of these smokingrelated disease states compared with patients matched by age, sex, and smoking histories who do not have pulmonary function impairment. Accordingly, simple spirometric measurements are both specific and nonspecific predictors of premature mortality from many causes. See also p 2741. More than a century ago, John Hutchinson, MB, a surgeon, invented the spirometer.<sup>1</sup>He offered his device to the insurance industry of London, England, as a potential tool to predict patients
Corrigendum to: Hepatitis C virus NS2 protein triggers endoplasmic reticulum stress and suppresses its own viral replication [J Hepatol. 2010 Nov;53(5):797–804]
Authors: Annette von dem Bussche, Raiki Machida, Ke Li, Gideon Loevinsohn, Amrin Khander, Jianguo Wang, Takaji Wakita, Jack R. Wands, Jisu Li
Journal: Journal of Hepatology (2011)
The structure of cardiological revolutions. James B. Herrick Lecture.
Authors: B E Sobel
Journal: Circulation (1993)

Four revolutions are transforming the cardiology of our day. The first is a social revolution. It has resulted in plummeting esteem for the medical profession reflecting disenchantment coupled with the rapid emergence of the recognition that health care is a right rather than a privilege. The second revolution, interventional cardiology, has provided powerful therapeutic tools demanding technical as well as cognitive expertise. The third, the revolution in molecular and cellular biology, is transforming our understanding of mechanisms underlying disease. Because of the seminal importance of progress in basic science to advances in clinical cardiology, features of these three revolutions are being synthesized in a fourth, a revolution transforming cardiology itself. Novel approaches are needed for optimal training of clinicians with diverse areas of interest, investigators in fundamental and clinical research, house staff, and students; for optimal use of clinical and research resources; and for optimal responsiveness to the needs of patients. They must be developed with cognizance of and fidelity to our clinical and scientific heritage.
The Fas/Fas ligand apoptosis pathway underlies immunomodulatory properties of human biliary tree stem/progenitor cells
Authors: Massimo Riccio, Gianluca Carnevale, Vincenzo Cardinale, Lara Gibellini, Sara De Biasi, Alessandra Pisciotta, Guido Carpino, Raffaele Gentile, Pasquale B. Berloco, Roberto Brunelli, Carlo Bastianelli, Chiara Napoletano, Alfredo Cantafora, Andrea Cossarizza, Eugenio Gaudio, Domenico Alvaro, Anto De Pol
Journal: Journal of Hepatology (2014)
Mitochondrial respiration scavenges extramitochondrial superoxide anion via a nonenzymatic mechanism.
Authors: D M Guidot, J E Repine, A D Kitlowski, S C Flores, S K Nelson, R M Wright, J M McCord
Journal: Journal of Clinical Investigation (1995)

We determined that mitochondrial respiration reduced cytosolic oxidant stress in vivo and scavenged extramitochondrial superoxide anion (O2-.) in vitro. First, Saccharomyces cerevisiae deficient in both the cytosolic antioxidant cupro-zinc superoxide dismutase (Cu,Zn-SOD) and electron transport (Rho0 state) grew poorly (P < 0.05) in 21% O2 compared with parent yeast and yeast deficient only in electron transport or Cu,Zn-SOD, whereas anaerobic growth was the same (P > 0.05) in all yeast. Second, isolated yeast and mammalian mitochondria scavenged extramitochondrial O2-. generated by xanthine/xanthine oxidase. Yeast mitochondria scavenged 42% more (P < 0.05) extramitochondrial O2-. during pyruvate/malate-induced respiration than in the resting state. Addition of either antimycin (respiratory chain inhibitor) or FCCP (respiratory chain uncoupler) prevented increased O2-. scavenging. Mitochondria isolated from yeast deficient in the mitochondrial manganous superoxide dismutase (Mn-SOD) increased (P < 0.05) O2-. scavenging 56% during respiration. This apparent SOD activity, expressed in units of SOD activity per milligram of mitochondrial protein, was the same (9 +/- 0.6 vs. 10 +/- 1.0; P = 0.43) as the O2-. scavenging of mitochondria with Mn-SOD, suggesting that respiration-dependent mitochondrial O2-. scavenging was nonenzymatic. Finally, isolated rat liver and lung mitochondria also increased (P < 0.05) O2-. scavenging during respiration. We speculate that respiring mitochondria, via the protonmotive pump, present a polarized, proton-rich surface that enhances nonenzymatic dismutation of extramitochondrial O2-. and that this is a previously unrecognized function of mitochondrial respiration with potential physiological ramifications.
Letter: E.S.R. versus plasma viscosity readings in the old.
Authors: R D Eastham
Journal: BMJ (1973)

be widespread I now accept the majority view that there should be a second person present to give the anaesthetic; but this would bring no gain in safety unless that person fully understood and kept constantly in mind the peculiar danger of anaesthesia in the dental chair.Whether this person needs to be qualified in medicine or dentistry is open to question.I think not and have suggested67 the establishment of an alterna- tive grade.-Iam, etc.,
MODELING THE HEART FROM ECHOCARDIOGRAPHIC STRAIN DATA, COLLECTED ON THE INTERNATIONAL SPACE STATION
Authors: Patrick A. Gladding, Shafkat Anwar, Kazuaki Negishi, Zoran Popovic, Jagir R. Hussan, Thomas Marwick, Peter Hunter, Mohammed Kassemi, Benjamin Levine, Jim Thomas
Journal: Journal of the American College of Cardiology (2011)
Coexistence and upregulation of three types of opioid receptors, mu, delta and kappa, in human hypertrophic scars
Authors: B. Cheng, H-W. Liu, X-B. Fu, Z-Y. Sheng, J-F. Li
Journal: British Journal of Dermatology (2008)

Pruritus or nociceptive pain is a significant clinical problem of hypertrophic scars. Recently emerging evidence has indicated the possible involvement of opioid receptors (ORs) in abnormal cutaneous sensation; however, little is known about the pathophysiological role of ORs in local cacaesthesia in hypertrophic scars.To study the expression profile of ORs in normal human skin and hypertrophic scars with cacaesthesia.Skin biopsy was performed in 10 patients newly diagnosed as having hypertrophic scars with cacaesthesia, and in 10 healthy individuals. Parts of these skin tissues were subjected to primary culture of keratinocytes and fibroblasts. Localization of ORs was examined by immunofluorescence staining and quantitation of ORs was performed by real-time polymerase chain reaction (PCR).Immunofluorescence staining revealed that OR types mu (MOR), delta (DOR) and kappa (KOR) were coexpressed and located mainly in the keratinocytes and fibroblast-like cells. Real-time PCR indicated that the expression of MOR, DOR and KOR in hypertrophic scars was enhanced in comparison with normal skin. Consistent with the results from skin biopsy, we observed enhanced expression of MOR, DOR and KOR in the cultured keratinocytes and fibroblasts derived from hypertrophic scars in comparison with those derived from normal skin.Our results demonstrate that expression of three types of ORs, MOR, DOR and KOR, was markedly upregulated in human hypertrophic scars, suggesting a possible link between upregulated ORs and local cacaesthesia in hypertrophic scars.
Abrogating Cbl-b in effector CD8+ T cells improves the efficacy of adoptive therapy of leukemia in mice
Authors: Ingunn M. Stromnes, Joseph N. Blattman, Xiaoxia Tan, Sara Jeevanjee, Hua Gu, Philip D. Greenberg
Journal: Journal of Clinical Investigation (2010)

The clinical use of adoptive immunotherapy with tumor-reactive T cells to treat established cancers is limited in part by the poor in vivo survival and function of the transferred T cells. Although administration of exogenous cytokines such as IL-2 can promote T cell survival, such strategies have many nonspecific activities and are often associated with toxicity. We show here that abrogating expression of Casitas B-lineage lymphoma b (Cbl-b), a negative regulator of lymphocyte activation, in tumor-reactive CD8(+) T cells expanded ex vivo increased the efficacy of adoptive immunotherapy of disseminated leukemia in mice. Mechanistically, Cbl-b abrogation bypassed the requirement for exogenous IL-2 administration for tumor eradication in vivo. In addition, CD8(+) T cells lacking Cbl-b demonstrated a lower threshold for activation, better survival following target recognition and stimulation, and enhanced proliferative responses as a result of both IL-2-dependent and -independent pathways. Importantly, siRNA knockdown of Cbl-b in human CD8(+)CD28- effector T cell clones similarly restored IL-2 production and proliferation following target recognition independent of exogenous IL-2, enhanced IFN-γ production, and increased target avidity. Thus, abrogating Cbl-b expression in effector T cells may improve the efficacy of adoptive therapy of some human malignancies.
Evaluation of left ventricular function (ejection fraction and segmental wall motion) by single pass radioisotope angiography.
Authors: J A Jengo, I Mena, A Blaufuss, J M Criley
Journal: Circulation (1978)

Changes in ejection fraction (EF) and segmental wall motion (SWM) have been shown to be sensitive indicators of left ventricular (LV) function. This information is only obtainable by contrast angiography or gated blood pool scans. Gated studies assume a fixed geometry for the LV for EF determinations, are lengthy and limited primarily to the LAO projection. We correlated contrast and Tc-99m pertechnetate angiograms by singl pass radioisotope angiography (immediately preceding the contrast study) in 12 patients. EF was calculated from the LV time/activity curve and values ranged from .21 to .72. Angiographic correlation yielded r = 0.97. Regional LV wall motion was evaluated by dividing a summated cardiac cycle into 16 frames and dynamically and sequentially displaying these frames. Regional wall motion evaluation of four LV quadrants correlated well with angiography (r = 0.97). For quantitation these images were divided into four anterior and four inferior segments and the areas of respective segments were compared and expressed as a shortening fraction. SWM compared favorably with angiographic determinations (r ranged from 0.70 to 0.99). Thus, single pass radioisotopic determinations of EF and SWM in the RAO projection correlated well with the angiographic values and provide essential quantitative information of LV function otherwise unobtainable at the bedside.