tbuckley/cabot-search huggingface dataset:
Hepatic Secretion of Lipoproteins in the Rat and the Effect of Experimental Nephrosis
Authors: Julian B. Marsh, Charles E. Sparks
Journal: Journal of Clinical Investigation (1979)

Livers from normal and nephrotic rats were perfused by the nonrecirculating technique. Nephrosis was studied on the 7th d after the injection of puromycin animonucleoside. Amino acid-labeled lipoproteins (d < 1.21) were isolated from the perfusion medium by agarose column chromatography or by sequential density ultracentrifugation. In both groups of animals, in addition to very low density lipoproteins and nascent high density lipoproteins, column chromatography revealed the presence of a peak of 2-3 × 106 daltons. This peak contained lipoproteins of densities corresponding to <1.006, 1.006 < d < 1.02, and 1.02 < d < 1.06, which indicated that rat liver secretes a heterogeneous mixture of triglyceride-rich lipoproteins.
Bilateral Primary Carcinoma of the Ureter
Authors: Jay Y. Gillenwater
Journal: JAMA (1966)

PRIMARY TUMORS of the ureter are uncommon, and bilateral malignant tumors of the ureter occurring simultaneously are rare. There have been previously reported only five cases of bilateral primary ureteral tumors<sup>1-5</sup>and two other cases<sup>6,7</sup>which occurred asynchronously. This case is noteworthy because of the rarity of the lesion, the paucity of presenting symptoms, the elderly age of the patient, and the concomitant finding of papillary carcinoma in the bladder. <h3>Report of a Case</h3> The patient (514124), an 81-year-old white sawmill worker, was admitted to the University of Virginia Hospital with a chief complaint of several episodes of hematuria and intermittent mild left flank pain for five months. For three years, he also had noticed increasing difficulty with urination, frequency, and nocturia (three to four times). The patient was normotensive and appeared somewhat younger than his stated age. Review of systems was non-contributory and past history was negative.
DOES CHLOROQUINE CAUSE HYPOGLYCAEMIA IN THE ABSENCE OF CLINICAL MALARIA?
Authors: J.E. Ogbuokiri, M.J. Brueton, B.M. Greenwood, N.J. White, K.D. Miller, K. Marsh, C.D. Berry, R.C. Turner, D.H. Williamson, J. Brown
Journal: The Lancet (1987)
Increased stratum corneum turnover induced by subclinical irritant dermatitis
Authors: K.-P. WILHELM, JENNELLE C. SAUNDERS, H.I. MAIBACH
Journal: British Journal of Dermatology (1990)

The chronic effects of the irritant sodium lauryl sulphate (SLS) on stratum corneum (SC) barrier function, determined by transepidermal water loss (TEWL) measurements and on epidermal cell kinetics, estimated by stratum corneum turnover time (SCTT) determination (dansyl chloride staining method), were investigated in 18 healthy female volunteers. SLS (7·5%) was applied without occlusion for 20 min once daily, over a period of 3 weeks (5 days a week) on dansyl chloride‐stained skin and on untreated skin. SCTT of untreated skin (19·3 ± 0·8 days; mean ± SEM) was not changed by daily treatment with water (control) (19·3±2.0) but was significantly reduced by SLS (10·9±0·6; P0·0001; compared to controls). However, TEWL was increased in SLS‐treated sites 1·5‐fold after 4 days of treatment (5·3±0·6 vs. 3·5 ± 0·3; P<0·001). At the end of the second week, TEWL was increased 2.6‐fold and after 3 weeks TEWL was 3·3 times higher than in controls (13·0±1·6 vs. 3·9, P0.0001) The intensity of SLS‐induced irritation as measured by TEWL was significantly correlated with baseline TEWL (r=0·50; P0·02) and significantly negatively correlated with SCTT of SLS treated sites (r=− 50; P0·02) but not with SCTT of untreated skin (r=0·19).
Common variants at CD40 and other loci confer risk of rheumatoid arthritis
Authors: Soumya Raychaudhuri, Elaine F Remmers, Annette T Lee, Rachel Hackett, Candace Guiducci, Noël P Burtt, Lauren Gianniny, Benjamin D Korman, Leonid Padyukov, Fina A S Kurreeman, Monica Chang, Joseph J Catanese, Bo Ding, Sandra Wong, Annette H M van der Helm-van Mil, Benjamin M Neale, Jonathan Coblyn, Jing Cui, Paul P Tak, Gert Jan Wolbink, J Bart A Crusius, Irene E van der Horst-Bruinsma, Lindsey A Criswell, Christopher I Amos, Michael F Seldin, Daniel L Kastner, Kristin G Ardlie, Lars Alfredsson, Karen H Costenbader, David Altshuler, Tom W J Huizinga, Nancy A Shadick, Michael E Weinblatt, Niek de Vries, Jane Worthington, Mark Seielstad, Rene E M Toes, Elizabeth W Karlson, Ann B Begovich, Lars Klareskog, Peter K Gregersen, Mark J Daly, Robert M Plenge
Journal: Nature Genetics (2008)
A long-term hypopigmentary effect of thorium-X on freckled skin
Authors: A.S. BREATHNACH
Journal: British Journal of Dermatology (1982)

Journal Article A long‐term hypopigmentary effect of thorium‐X on freckled skin Get access A.S. BREATHNACH A.S. BREATHNACH Department of Anatomy and Cell Biology, St Mary's Hospital Medical School, London W2 1PG Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 106, Issue 1, 1 January 1982, Pages 19–25, https://doi.org/10.1111/j.1365-2133.1982.tb00897.x Published: 01 January 1982 Article history Accepted: 26 March 1981 Published: 01 January 1982
Bleeding Gastric Erosions
Authors: T. P. Casey
Journal: BMJ (1967)

In our work at the Pneumoconiosis Research Unit we actually used Indian ink instead of glycerol-water, as this gives a per- manent deposit on which differential counts can be made.In practice these turned out to be uninformative as the maximum drop- let size dominated the result, and it is a rather messy technique.In our studies we found an enormous range of performance, some nebulizers marketed by reputable firms having virtually no delivery and others producing dense clouds of droplets 20-30 microns in diameter.Inquiry among commercial firms produced no better account of test procedure than that given to Bruce by British Drug Houses.-Iam, etc.,
Transient Impairment of Vasomotion Function After Successful Chronic Total Occlusion Recanalization
Authors: Alfredo R. Galassi, Salvatore D. Tomasello, Filippo Crea, Luca Costanzo, Maria Barbara Campisano, Francesco Marzá, Corrado Tamburino
Journal: Journal of the American College of Cardiology (2012)
Holo-Retinol–Binding Protein and Its Receptor STRA6 Drive Oncogenic Transformation
Authors: Daniel C. Berry, Liraz Levi, Noa Noy
Journal: Cancer Research (2014)

Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP). At some tissues, RBP is recognized by STRA6, a plasma membrane protein that serves a dual role: it transports retinol from extracellular RBP into cells and it transduces a signaling cascade mediated by the Janus kinase JAK2 and the transcription factors STAT3 and STAT5. We show here that expression of RBP and STRA6 is markedly upregulated in human breast and colon tumors, that holo-RBP/STRA6 signaling promotes oncogenic properties, and that STRA6 expression is critical for tumor formation by colon carcinoma cells in vivo. The holo-RBP/STRA6 pathway also efficiently induces fibroblasts to undergo oncogenic transformation, rendering them highly tumorigenic. These data establish that holo-RBP and its receptor STRA6 are potent oncogenes and suggest that the pathway is a novel target for therapy of some human cancers.
Atrial septal aneurysm: a cause for midsystolic click. Report of a case and review of the literature.
Authors: M D Alexander, K R Bloom, P Hart, F D'Silva, J P Murgo
Journal: Circulation (1981)

A patient who was evaluated for a midsystolic click was found to have an aneurysm of the atrial septum as an isolated anomaly. Bulging of this aneurysm into the right atrium was associated with the production of the click. Echo-, phono-, and angiocardiographic features are presented, with a review of the literature on atrial septal aneurysms. These aneurysms, although rare, should be considered in the differential diagnosis of patients with midsystolic click.
When Medicine Went Mad: Bioethics and the Holocaust
Authors: Burton C. Einspruch
Journal: JAMA (1993)

Courage is required of an individual who has been touched by the Holocaust, as was Arthur L. Caplan, PhD, to write about it. (His father, Sidney, was among the American troops that liberated Dachau.) Dr Caplan, the prominent director of the Center for Biomedical Ethics at the University of Minnesota, organized a conference in May 1989, which examined the bioethical implications of the Holocaust. The articles published in his book represent the product of that meeting. Countless books have been written about the Holocaust by individuals as divergent as revisionist historians who wish to deny its existence and victims who bear the scars of this monstrous experience. This book is divided in a very readable fashion into five main segments: "Testimonies," "Medicine, Bioethics, and Nazism," "The Use of Information From Nazi 'Experiments,'" "Medical Killing and Euthanasia: Then and Now," and "The Abuse of Medicine and the Legacy of the Holocaust."
"ARE MITOCHONDRIA IDENTICAL WITH BACTERIA?"
Authors: S. B. Wolbach
Journal: JAMA (1922)

<h3>To the Editor:</h3> —The article of Cowdry and Olitsky on "Differences Between Mitochondria and Bacteria" is wholly deserving of your editorial comment (The Journal, Nov. 26, 1922, p. 1848). It is gratifying to have grotesque conceptions in biology neatly disposed of. To those who have worked with<i>Rickettsia</i>bodies, however, the statement that their significance in typhus fever, trench fever and other conditions has been influenced by the researches of Cowdry and Olitsky seems unwarranted. In connection with trench fever,<i>Rickettsia</i>bodies have been seen only in extracellular situations in lice. Mitochondria, at least, are always intracellular. The association of<i>Rickettsia</i>with typhus fever is most strongly supported by their occurrence in experimentally fed lice, and under such conditions<i>Rickettsia</i>occur in such numbers as to distend and disrupt the epithelial cells of the louse's stomach, a phenomenon not even suspected to occur from the multiplication of mitochondria, least of
Possible Synergism Between Iodine And Lithium Carbonate
Authors: Jorgen Vesterdal Jorgensen
Journal: JAMA (1973)

To the Editor.—  In reference to the article inThe Journalby Dr. Luby and colleagues (218:1298, 1971) and the comments by Dr. Wiener (220:587, 1972) and Dr. Whybrow (221:506, 1972) concerning the possible contributive effect of iodide to the antithyroid action of  carbonate, we want to mention that one of the first published cases of myxedema attributed to excessive iodide administration might have been a lithium plus iodide hypothyroidism.  In 1953, Morgans and Trotter published two cases of myxedema attributed to iodide administration. One of the patients was a 66-year-old man who was myxedematous on admission with a basal metabolic rate (BMR) of 85% and a plasma cholesterol level of 370 mg/100 ml. Measurements of radioactive iodine neck to thigh ratios four days and ten days after admission showed a shift from normal to thyrotoxic values. Repeated measurements 31 and 76 days after admission demonstrated that the thyroid
Aspirin and Analgesic Nephropathy
Authors: Ronald D. Emkey
Journal: JAMA (1982)

To assess the effects of long-term aspirin ingestion on renal function, we studied all of the patients at the Massachusetts General Hospital Arthritis Clinic who had been taking aspirin continuously for ten or more years. Aspirin ingestion was documented by multiple, random, unannounced blood salicylate levels. Most of these 46 patients had seropositive rheumatoid arthritis. All creatinine and BUN levels were normal. Maximum recorded specific gravities were greater than 1.019 in 43 of 46 patients. These data suggest that long-term salicylate ingestion does not cause renal damage. (<i>JAMA</i>1982;247:55-57)
Thyroid disease and vitamin D deficiency
Authors: S Kivity, N Agmon-Levin, M Zisappl, Y Shapira, V Barak, K Danko, Z Szekanecz, M Szyper-Kravitz, P langevitz, B Gilburd, Y Shoenfeld
Journal: Annals of the Rheumatic Diseases (2010)

BackgroundThe role of vitamin D as an immune-modulator has been emphasised in recent years, and low levels of this hormone were observed in several autoimmune diseases. 1Vitamin D mediates its effect through binding to vitamin D receptor (VDR) and activation of VDR-responsive genes.VDRgene polymorphism was found to associate with autoimmune thyroid diseases (AITD), however studies exploring levels of vitamin D in patients with AITD are scarce and yield confl icting results.We therefore evaluated the levels of vitamin D in patients with AITD compared with non-autoimmune thyroid disease and healthy subjects.Methods Serum vitamin D levels were measured in 50 patients with AITDs, 42 patients with non-autoimmune thyroid diseases and 98 healthy subjects using the Liaison chemiluminescent immunoassays (DiaSorin, Italy).Vitamin D defi ciency was designated at <10 ng/ml.Patients were evaluated for anti-thyroid antibodies, thyroid function and demographic parameters. ResultsThe prevalence of vitamin D defi ciency was significantly higher in patients with AITD compared with healthy individuals (72% vs 30.6%; p<0.001), and in patients with Hashimoto's thyroiditis compared with patients with non-AITD (79% vs 52%; p<0.05).Vitamin D defi ciency significantly correlated with the presence of anti-thyroid antibodies (p=01) and a trend towards an association with disturbed thyroid function was also observed (p=0.59).Conclusion Signifi cantly low levels of vitamin D were documented in patients with AITD, and were related to the presence of anti-thyroid antibodies and disturbed thyroid function.Although further studies are required, the role of vitamin D in the pathogenesis of autoimmune thyroid diseases is suggested and supplementation should be considered.
Coffee or decaff?
Authors: S E GROBER
Journal: Annals of the Rheumatic Diseases (2001)

This potentially valuable information about a relation between coffee consumption and the presence of rheumatoid factor1 is difficult to evaluate because of a lack of clarity in definitions. What is meant by "coffee"? Is coffee, caffeinated or decaffeinated? This is an obvious distinction that … Dr Markku Heliövaara, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland markku.heliovaara{at}ktl.fi
Comparison of thallium-201 scanning in idiopathic dilated cardiomyopathy and severe coronary artery disease.
Authors: R F Dunn, R F Uren, N Sadick, G Bautovich, A McLaughlin, M Hiroe, D T Kelly
Journal: Circulation (1982)

To determine whether cardiomyopathy could be distinguished from coronary artery disease, we used thallium scanning to study 25 patients with severe left ventricular dysfunction and chronic heart failure. Ten patients had normal coronary arteries and idiopathic cardiomyopathy (ejection fraction 20 +/- 5%), and 15 patients had multivessel coronary disease and left ventricular dysfunction (ejection fraction 25 +/- 6%). The exercise time and maximal heart rate were similar in the two groups. Two patients with cardiomyopathy and 11 with coronary artery disease had a positive exercise ECG (p less than 0.05). Thallium scans showed perfusion defects in all 25 patients. The perfusion defects were complete in nine coronary artery disease patients (60%) and in one patient (10%) with cardiomyopathy (p less than 0.05). Extensive defects involving more than 40% of the left ventricular circumference, the number of segments involved, redistribution on the 4-hour scan, lung uptake and ventricular size were similar in the two groups. Perfusion defects on thallium scanning can occur in patients with idiopathic dilated cardiomyopathy and chronic heart failure. Thallium scanning cannot be reliably used in patients with chronic heart failure to distinguish coronary artery disease from cardiomyopathy unless complete defects are present.
Influenza: The Viruses and the Disease
Authors: Fred M. Davenport
Journal: JAMA (1977)

This excellent monograph is a comprehensive statement of the authors' views of the biology of influenza and of the influenza viruses. Coverage of modern history of influenza extends from London in 1933 to Fort Dix, NJ, in 1976. Earlier experiences are described using selected epidemiologic records and seroepidemiologic findings. Schild provides a thorough yet concise treatment of the viruses of human disease and their relationship to those of lower animals and birds. His participation in many of the studies that disclosed these relationships contributes to the authenticity of the account. Basic concepts of molecular virology are boldly set forth in chapters 2,3, and 4. Sir Charles has been a continuous student of clinical, epidemiologic, and virological features of influenza since the 1930s. Chapter 5, on human disease, comprises an authoritative in-depth description of the illness and its complications. Chapter 6 and 7 review epidemiologic records from 1562 to the present,
Color Atlas of Cardiovascular Pathology
Authors: Robert W. Wissler
Journal: JAMA (1987)

This is an elegant book with the avowed aim of providing a bridge between traditional and new techniques of cardiopathology. It achieves this goal as well as can be done by the printed page. Echocardiography, now widely carried out, presents the clinician with the heart in its dynamic state of activity by planar dissection of this vital organ as it is accessed by means of a window through the barrier of the chest wall. This technique amplifies and supplements the knowledge gained in the course of autopsies, which often yield detailed knowledge of altered structure-function relationships as prosectors follow the pathway established so long ago by William Harvey for the direction of blood flow. Professor Davies'<i>Atlas of Cardiovascular Pathology</i>represents 20 years of observation and research by a busy clinician. The excellent photographs of gross pathology and the well-selected photomicrographs are derived from his personal collection of specimens, supplemented
Protein kinase C-η regulates resistance to UV- and γ-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation
Authors: Isa M. Hussaini, Joan E. Carpenter, Gerard T. Redpath, Julianne J. Sando, Mark E. Shaffrey, Scott R. VandenBerg
Journal: Neuro-Oncology (2002)

Both increased cell proliferation and apoptosis play important roles in the malignant growth of glioblastomas. We have demonstrated recently that the differential expression of protein kinase C (PKC)-eta increases the proliferative capacity of glioblastoma cells in culture; however, specific functions for this novel PKC isozyme in the regulation of apoptosis in these tumors has not been defined. In the present study of several glioblastoma cell lines, we investigated the role of PKC-eta in preventing UV- and gamma-irradiation-induced apoptosis and in caspase-dependent signaling pathways that mediate cell death. Exposure to UV or gamma irradiation killed 80% to 100% of PKC-eta-deficient nonneoplastic human astrocytes and U-1242 MG cells, but had little effect on the PKC-eta-expressing U-251 MG and U-373 MG cells. PKC-eta appears to mediate resistance to irradiation specifically such that when PKC-eta was stably expressed in U-1242 MG cells, more than 80% of these cells developed resistance to irradiation-induced apoptosis. Reducing PKC-eta expression by transient and stable expression of antisense PKC-eta in wild-type U-251 MG cells results in increased sensitivity to UV irradiation in a fashion similar to U-1242 MG cells and nonneoplastic astrocytes. Irradiation of PKC-eta-deficient glioblastoma cells resulted in the activation of caspase-9 and caspase-3, cleavage of poly (ADP-ribose) polymerase (PARP), and a substantial increase in subdiploid DNA content that did not occur in PKC-eta-expressing tumor cells. A specific inhibitor (Ac-DEVD-CHO) of caspase-3 blocked apoptosis in PKC-eta-deficient U-1242 MG cells. The data demonstrate that resistance to UV and gamma irradiation in glioblastoma cell lines is modified significantly by PKC-eta expression and that PKC-eta appears to block the apoptotic cascade at caspase-9 activation.
Coexistence of pemphigus vulgaris and ocular cicatricial pemphigoid
Authors: Jean Buhac, Kailash Bhol, Tomas Padilla, C.Stephen Foster, A.Razzaque Ahmed
Journal: Journal of the American Academy of Dermatology (1996)

We describe the case of a patient with both pemphigus vulgaris limited to the oral cavity and ocular cicatricial pemphigoid. The diagnoses were established by means of histopathologic examination and direct and indirect immunofluorescence studies and confirmed by immunoblot analysis of serum. Treatment with dapsone resulted in a prolonged remission of the ocular cicatricial pemphigoid. The pemphigus vulgaris has remained localized to the oral cavity and has responded to sublesional corticosteroid injections.
Disinvestment from low value clinical interventions: NICEly done?
Authors: Sarah Garner, Peter Littlejohns
Journal: BMJ (2011)

Over the past 10 years NICE has identified over 800 clinical interventions for potential disinvestment. But <b>Sarah Garner</b> and <b>Peter Littlejohns</b> report that although disinvestment will increase efficiency and quality, the opportunity for cash saving is unlikely to meet the necessary targets
Night pain in arthritis: patients at risk from prescribed night sedation.
Authors: P G Hardo, S A Wasti, A Tennant
Journal: Annals of the Rheumatic Diseases (1992)

To assess the problem of night pain and the use of hypnotic drugs in patients with rheumatic diseases 165 consecutive patients (mean age 58.5 years) were assessed and questioned about night pain and the use of drugs including night sedation. Most of the patients (106 (64%)) were women. A total of 32 (19%) patients were receiving night sedation for a mean duration of 43.9 months. Fourteen patients (13 women) were using these drugs to treat insomnia related to pain. The mean visual analogue pain score for night pain showed a significant difference between those receiving night sedation (5.2) and those who were not (3.7). Of the 70 patients who answered the Stanford Health Assessment Questionnaire (HAQ), those receiving night sedation also had a significantly higher mean score (1.91) than those who were not (1.2), suggesting that patients receiving night sedation were more clinically disabled. Codeine was used by more (34%) patients receiving night sedation than those who were not (18%) suggesting that those receiving night sedation had more pain. These results highlight the need for better pain management in patients with rheumatic diseases to minimise the risk of prescribing addictive drugs such as hypnotic drugs and codeine.
Postmyocardial Infarction Syndrome
Authors: NELSON J. WEISER, MILTON KANTOR, HOLLIS K. RUSSELL
Journal: Circulation (1959)

A new syndrome that is likely to follow myocardial infarction has recently been described. The cardinal manifestations of this syndrome may easily be confused with other, more common sequels of myocardial infarction, including cardiac failure, further infarction of the myocardium, and pulmonary embolism. The result of such confusion may be inappropriate therapy. This paper reviews the recent literature and our own experience with this syndrome and discusses the therapeutic implications.
Liver fibrosis assessment with semiquantitative indexes and image analysis quantification in sustained-responder and non-responder interferon-treated patients with chronic hepatitis C
Authors: Trinidad Caballero, Alejandro Pérez-Milena, Marco Masseroli, Francisco O'Valle, Francisco J Salmerón, Raimundo M.G Del Moral, Guillermo Sánchez-Salgado
Journal: Journal of Hepatology (2001)
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma
Authors: Yun-Yan Xiang, Shuhe Wang, Mingyao Liu, Jeremy A Hirota, Jingxin Li, William Ju, Yijun Fan, Margaret M Kelly, Bin Ye, Beverley Orser, Paul M O'Byrne, Mark D Inman, Xi Yang, Wei-Yang Lu
Journal: Nature Medicine (2007)