tbuckley/cabot-search huggingface dataset:
Adjunctive Effect of Acupuncture to Refractive Correction on Anisometropic Amblyopia
Authors: Dennis S.C. Lam, Jianhao Zhao, Li Jia Chen, Yunxiu Wang, Chongren Zheng, Qiaoer Lin, Srinivas K. Rao, Dorothy S.P. Fan, Mingzhi Zhang, Ping Chung Leung, Robert Ritch
Journal: Ophthalmology (2011)
Monthly Rhythm of Libido in Married Women
Authors: R. D. Hart
Journal: BMJ (1960)

Since classical times there has been discussion on the existence or non-existence of variations in libido in women during the menstrual cycle.*This discussion reached its peak in the nineteenth and early part of the present century.The main difference of opinion lay between those who believed that there was increased libido in association with menstruation itself-that is, just before, just after, or during, or various combinations thereof (for example, Campbell, 1891 ; Kossmann, 1903; Havelock Ellis, 1910)-and those who denied the existence of any monthly enhancement of sexual desire in women (for example, Ftirbringer, 1918).The more recent literature continues to show marked differences of opinion.Thus Corner (1952) maintained that libido is maximal just before or just after menstrua- tion, whereas Stopes (1937) considered the monthly rhythm to have two peaks, one just before menstruation and the other at mid-cycle.On the other hand, Eckstein and Zuckerman (1956) stated that " sexual behaviour in women very rarely manifests any rhythmic pattern."However, according to Swyer (1954), " Psychic changes occur throughout the menstrual cycle.So great are the variations in different individuals that generalizations are difficult to draw.Thus, whereas some women lose all or most of their libido during the menstrual period,
Validation of terminal peptide of procollagen III for the detection and assessment of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease
Authors: Sudeep Tanwar, Paul M. Trembling, Indra N. Guha, Julie Parkes, Philip Kaye, Alastair D. Burt, Stephen D. Ryder, Guruprasad P. Aithal, Christopher P. Day, William M. Rosenberg
Journal: Hepatology (2012)

Liver biopsy is the reference standard for the detection of nonalcoholic steatohepatitis (NASH) within nonalcoholic fatty liver disease (NAFLD). The aim of this study was to identify a biomarker of NASH in patients without significant fibrosis. In all, 172 patients from two centers with biopsy-proven NAFLD were included in this study. Eighty-four patients from a single center were included as a derivation cohort and 88 patients from a second center were included as a validation cohort. Serum samples were tested for candidate markers of fibrosis and inflammation alongside hematological and biochemical markers. Among patients without advanced fibrosis, terminal peptide of procollagen III (PIIINP) was the only marker found to be associated with a histological diagnosis of NASH in both cohorts. PIIINP also correlated with the total NAFLD activity score (NAS) and its constituent components (P < 0.001). Area under receiver operating characteristic curve (AUROC) for PIIINP in discriminating between NASH and simple steatosis (SS) was 0.77-0.82 in patients with F0-2 fibrosis and 0.82-0.84 in patients with F0-3 fibrosis. PIIINP was elevated in patients with advanced fibrosis, the overwhelming majority of whom had NASH. When incorporating patients with all degrees of fibrosis from both cohorts, PIIINP was able to discriminate between patients with SS and those with NASH or advanced fibrosis with AUROC 0.85-0.87.PIIINP discriminates between SS and NASH or advanced fibrosis. The use of a single biomarker in this context will be of clinical utility in detecting the minority of patients with NAFLD who have NASH or advanced fibrosis related to NASH.
Hospitals lag behind primary care in going digital, conference hears
Authors: M. Limb
Journal: BMJ (2013)

NHS trusts have less than a month to apply for cash from a new £260m technology fund set up to help them go paperless and develop digital care records systems.

The fund, announced in May by NHS England, became operational on 1 July.1 It was meant to support the “rapid progression” from traditional patient notes and prescriptions to integrated digital care records that connect across providers, as well as electronic prescribing and referral systems.

Although trusts can choose which technologies to invest in, these systems will have to meet national standards in areas such as data security and interoperability with other systems. Trusts have until the end of July to …
Endoscopic Ligation for Non-Esophageal Variceal Upper Gastrointestinal Hemorrhage
Authors: R. M. Wong, S. Ota, A. Katoh, A. Yamauchi, K. Arai, K. Kaneko, M. Yazawa, F. Matsuzaki
Journal: Endoscopy (1998)

Background: Endoscopic ligation can be used for bleeding lesions in non-fibrotic tissue; however, only small numbers of patients with non-esophageal variceal upper gastrointestinal hemorrhage have been treated in this way. To evaluate the utility of the technique, we performed the procedure to treat hemorrhage not from esophageal varices during emergency endoscopy.
<i>−308GA</i>and<i>TNFB</i>polymorphisms in acute respiratory distress syndrome
Authors: M. N. Gong, W. Zhou, P. L. Williams, B. T. Thompson, L. Pothier, P. Boyce, D. C. Christiani
Journal: European Respiratory Journal (2005)

The −308GA and TNFB1 /2 polymorphisms of the tumour necrosis factor genes have been associated with increased susceptibility to, and mortality in sepsis, although, prior studies are not consistent. Their role in acute respiratory distress syndrome (ARDS) has not been evaluated. The current authors hypothesised that the −308A allele and TNFB22 genotype would be associated with increased susceptibility to, and mortality in ARDS. The above hypothesis was investigated in a nested case-control study of 441 Caucasian controls and 212 cases admitted to an intensive care unit with sepsis, trauma, aspiration or hyper-transfusions. The −308A and TNFB1 alleles were in linkage disequilibrium. These polymorphisms were not associated with ARDS susceptibility on crude analysis. On subgroup analyses, they were associated with either increased or decreased odds of developing ARDS depending on whether the clinical risk for ARDS results in direct or indirect pulmonary injury. The −308A allele was associated with increased 60-day mortality in ARDS, with the strongest association found among younger patients. There was no association between the TNFB polymorphism and ARDS mortality. The − 308GA , but not the TNFB12 , polymorphism was associated with increased mortality in acute respiratory distress syndrome, but their association with acute respiratory distress syndrome susceptibility depended on the site of injury predisposing to acute respiratory distress syndrome.
PLoS Medicine and Publication Ethics: When Is It Research?
Authors: Mary Ann Baily
Journal: PLoS Medicine (2007)

It is only about 25 years since the abolition or abandonment of TB sanatoria in South Africa.It is likely that there are people in South Africa who are familiar with the idea of isolation of TB patients from the general public emanating from the era of TB sanatoria, and it is conceivable that they are likely to be understanding of the reasons that were used to keep patients there during their treatment.These people could help to make the idea of isolation in sanatoria acceptable again to the general public.Anyway, the TB sanatoria of this era were rightfully regarded as hospitals, as indeed they were, and I cannot see why modern day sanatoria should be viewed any differently.Granted, with the likelihood that the patients detained in these envisaged isolation areas may be more likely to die than be discharged, it will be a mammoth task to convince the "detainees" to stay there or their families to allow them to be kept there, especially if they are minors or the elderly infi rm.It is a tough call but it is worth a try.
Carcinogen-Altered Genes in Rat Esophagus Positively Modulated to Normal Levels of Expression by Both Black Raspberries and Phenylethyl Isothiocyanate
Authors: Gary D. Stoner, Alan A. Dombkowski, Rashmeet K. Reen, Daniela Cukovic, Sridevi Salagrama, Li-Shu Wang, John F. Lechner
Journal: Cancer Research (2008)

Abstract Our recent study identified 2,261 dysregulated genes in the esophagi of rats that received a 1-week exposure to the carcinogen N-nitrosomethylbenzylamine (NMBA). We further reported that 1,323 of these genes were positively modulated to near-normal levels of expression in NMBA-treated animals that consumed dietary phenylethyl isothiocyanate (PEITC), a constituent of cruciferous vegetables. Herein, we report our results with companion animals that were fed a diet containing 5% freeze-dried black raspberries (BRB) instead of PEITC. We found that 462 of the 2,261 NMBA-dysregulated genes in rat esophagus were restored to near-normal levels of expression by BRB. Further, we have identified 53 NMBA-dysregulated genes that are positively modulated by both PEITC and BRB. These 53 common genes include genes involved in phase I and II metabolism, oxidative damage, and oncogenes and tumor suppressor genes that regulate apoptosis, cell cycling, and angiogenesis. Because both PEITC and BRB maintain near-normal levels of expression of these 53 genes, their dysregulation during the early phase of NMBA-induced esophageal cancer may be especially important in the genesis of the disease. [Cancer Res 2008;68(15):6460–7]
276 MULTIPLE NOVEL PEPTIDE EPITOPES IN HCV GENOTYPE-3A IDENTIFIED USING TWO PARALLEL APPROACHES
Authors: A. Boehmer, K. Pfafferott, I.S. Humphreys, M. Lucas, L. Swadling, G.M. Lauer, S. Gaudieri, P. Klenerman, E. Barnes
Journal: Journal of Hepatology (2011)
Histamine induced changes in breathing pattern may precede bronchoconstriction in selected patients with bronchial asthma.
Authors: A Fanelli, R Duranti, M Gorini, A Spinelli, F Gigliotti, G Scano
Journal: Thorax (1994)

BACKGROUND--In asthmatic patients methacholine or histamine challenge may result in more rapid and shallow breathing. Bronchoconstriction can also be associated with changes in the pattern of breathing. However, few studies, particularly in patients with asthma, have investigated the possibility that changes in the pattern of breathing may precede the onset of bronchoconstriction. METHODS--Eight subjects were selected from 34 consecutive asthmatic patients who had previously exhibited a significant increase in respiratory frequency (Rf) and decrease in tidal volume (VT) accompanying a 20% or greater fall in FEV1 during a histamine bronchial provocation test. These patients also had bronchial hyperresponsiveness (histamine PC20FEV1 0.1-0.25 mg/ml). VT, Rf, and the ratio of VT to Rf were evaluated breath by breath under control conditions and two minutes after inhalation of either saline or each of a series of progressively increasing concentrations of histamine. In each subject the coefficient of variation (CV) for each breathing pattern variable was calculated under control conditions and at each histamine concentration over at least 30-40 breaths. For FEV1, VT and Rf step by step coefficients of variation were averaged and the mean (2SD) CV was considered to represent a threshold value in each patient. RESULTS--Histamine challenge resulted in increased Rf and Rf/VT, and decreased VT and FEV1. In all but one subject change in Rf and Rf/VT beyond the threshold value preceded change in FEV1 beyond the threshold value. The threshold concentrations of histamine for Rf and Rf/VT did not correlate with the threshold value for FEV1. CONCLUSIONS--In selected asthmatic patients a change in breathing pattern occurs prior to a change in FEV1. These results suggest that narrowing of the airways, in terms of decrease in FEV1, does not play a major part in the initial change in the pattern of breathing. This may be caused by direct stimulation of vagal airway receptors.
A review of human carcinogens—Part B: biological agents
Authors: Véronique Bouvard, Robert Baan, Kurt Straif, Yann Grosse, Béatrice Secretan, Fatiha El Ghissassi, Lamia Benbrahim-Tallaa, Neela Guha, Crystal Freeman, Laurent Galichet, Vincent Cogliano
Journal: The Lancet Oncology (2009)
Left Lower Quadrant Mass
Authors: Jan P. Kaminski, David Ryan, Balasubramaniam Iyer
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Planning for Retirement
Authors: Charles M. Gaitz
Journal: JAMA (1977)

Retirement planning has become a legitimate concern of all physicians, especially those employed by agencies where retirement is compulsory. Faced with the possibility of retirement, whether forced or voluntary, and issues of competence and other related matters, many physicians are departing from the traditional pattern of working until they become incapacitated. The typical physician places high values on work and deprecates other activities. Busy practitioners who have spent little time with their families and in recreational pursuits find themselves unprepared for their altered status when they stop working. Little empirical information is available concerning physicians and retirement. Four proposed retirement patterns may help physicians plan successfully for retirement. (<i>JAMA</i>238:149-151, 1977)
Evaluation of Sino-atrial Node Function in Man by Overdrive Suppression
Authors: WILLIAM MANDEL, H. HAYAKAWA, RONALD DANZIG, HAROLD S. MARCUS
Journal: Circulation (1971)

Sino-atrial node (SAN) function was evaluated in 46 patients, three of whom had the sick sinus syndrome. Patients were paced from the right atrium for 15 to 180 sec at rates of 90, 110, 130, and 150 beats/min. The rapid cessation of pacing was associated with suppression of the SAN at all paced rates and at all durations of pacing. The observed pause was terminated by a sinus beat in all instances. The duration of pacing had little influence on the duration of the observed pause. The pause increased as the pacing rate was increased until, at a rate of 150 beats/min, a marked decrease in the pause was noted. Atropine (1.5-3.0 mg iv) diminished but did not eliminate the SAN suppression. Subthreshold pacing did not suppress SAN function. Three patients with sick sinus syndrome had a greater degree of SAN suppression than normal patients (4732 ± 415 msec [SSS] M ± sem ; 1041 ± 56 msec for normal patients). The determination of the duration of the pause following cessation of atrial pacing provides a technique for recognition of abnormalities of SAN function.
Geriatrics Training in General Internal Medicine Fellowship Programs: Current Practice, Barriers, and Strategies for Improvement
Authors: Steven R. Simon, Anne R. Fabiny, Jamie Kotch
Journal: Annals of Internal Medicine (2003)

To ensure its growth and prosperity, general internal medicine will need to embrace care of the elderly, research on aging, and geriatrics education as components of its core mission. Experts agree that general internal medicine fellows could benefit from increased opportunities in research on aging and geriatrics education; however, important barriers will hamper efforts to integrate geriatrics training into general internal medicine fellowship programs. This article reviews the barriers to integration and proposes solutions for overcoming those barriers. As a result of interviews and meetings with a broad representation of general internists, geriatricians, funding agencies, and policymakers, we propose 2 interventions: 1) the development of institutional program grants to foster collaboration between general internal medicine and geriatrics faculty in the training of general internal medicine fellows and 2) the creation of a 3-year fellowship program combining general internal medicine and geriatrics. This article discusses the importance of evaluating these and other programs intended to increase the geriatrics experience of general internal medicine fellows, and it describes the potential implications of these changes for a broad array of stakeholder institutions.
Mandatory Group Therapy for Exhibitionists
Authors: JAMES L. MATHIS, MABELLE COLLINS
Journal: American Journal of Psychiatry (1970)

The authors describe a program of group therapy for men arrested for exhibitionism. The program was based on three factors: mandatory attendance, common patient goals and symptoms, and male and female co-therapists. The thesis is that external pressure is needed to prevent the exhibitionist from using his pathological denial system to escape treatment prematurely. At least six months' attendance is desirable. The common goals and symptoms allowed focusing of group interaction.
SOCIOECONOMIC CRISIS AND INCIDENCE OF ACUTE MYOCARDIAL INFARCTION IN MESSINIA, GREECE
Authors: Emmanouil Makaris, George Michas, Renata Micha, Ioannis Pisimisis, Ilias Tsichlis, Dionysis Svoronos, Charalampos Panotopoulos, Dimitrios Gkotsis, George Koudounis, Spyridon Zompolos
Journal: Journal of the American College of Cardiology (2013)
Effects of Coffee and Napping on Nighttime Highway Driving
Authors: Pierre Philip
Journal: Annals of Internal Medicine (2007)

Letters6 February 2007Effects of Coffee and Napping on Nighttime Highway DrivingPierre Philip, MD, PhDPierre Philip, MD, PhDFrom Centre Hospitalier Universitaire Pellegrin, Bordeaux, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-3-200702060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: Dr. Yee wonders whether 1 of our participants could have had a nocturnal visual deficit that could explain the driving handicap recorded during our nighttime driving sessions. All participants were healthy, including their perceptual and psychomotor functions. We used the expertise of our copilots (who are professional driving instructors) to test the normative driving patterns of our participants in a 20-minute session. As Dr. Yee mentioned, the normative data of our participants were homogenous in our paper as in previous studies (1). This would already exclude a diurnal visual problem. Participant 7 behaved just like the other participants ...Reference1. Philip P, Sagaspe P, Moore N, Taillard J, Charles A, Guilleminault C, et al. Fatigue, sleep restriction and driving performance. Accid Anal Prev. 2005;37:473-8. [PMID: 15784201] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Centre Hospitalier Universitaire Pellegrin, Bordeaux, France.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effects of Coffee and Napping on Nighttime Highway Driving Pierre Philip , Jacques Taillard , Nicholas Moore , Sandrine Delord , Cédric Valtat , Patricia Sagaspe , and Bernard Bioulac Effects of Coffee and Napping on Nighttime Highway Driving Andrew J. Yee Metrics 6 February 2007Volume 146, Issue 3Page: 229KeywordsCoffeeConflicts of interestVisionVisual acuity ePublished: 6 February 2007 Issue Published: 6 February 2007 CopyrightCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The Causes of the Schizophrenias
Authors: ROBERT CANCRO
Journal: Annals of Internal Medicine (1972)

Editorials1 October 1972The Causes of the SchizophreniasROBERT CANCRO, M.D., MED.SC.D., F.A.C.P.ROBERT CANCRO, M.D., MED.SC.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-4-647 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEugen Bleuler (1) took an important step away from the disease-entity model when he introduced the concept of a group of schizophrenias. He recognized the existence of a number of end states that shared certain clinical similarities. He drew an analogy between the schizophrenias and the organic psychoses. Today we have gone beyond this position and recognize the schizophrenias, not only as a group of clinically similar end states, but as deriving from different initial states through different pathways. There is no single cause for the schizophrenias. The very complexity of this group of disorders suggests that the causes are...References1. BLEULER E: Dementia Praecox or The Group of Schizophrenias. New York, International Universities Press, 1950, p. 8 Google Scholar2. CANCRO R: A review of current research directions: their product and their promise, in The Schizophrenic Reactions: A Critique of the Concept, Hospital Treatment, and Current Research, edited by CANCRO R. New York, Brunner/Mazel, 1970, pp. 192-193 Google Scholar3. SLATER E: A review of earlier evidence on genetic factors, in The Transmission of Schizophrenia, edited by ROSENTHAL D, KETY SS. Oxford, Pergamon Press, 1968, pp. 15-26 Google Scholar4. ROSENTHAL D: Genetic research in the schizophrenic syndrome, in The Schizophrenic Reactions: A Critique of the Concept, Hospital Treatment, and Current Research, edited by CANCRO R. New York, Brunner/Mazel, 1970, pp. 245-258 Google Scholar5. HESTON L: Psychiatric disorders in foster home reared children of schizophrenic mothers. Br J Psychiat 112:819-825, 1966 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT CANCRO, M.D., MED.SC.D., F.A.C.P.Affiliations: University of Connecticut Health Center Hartford, Conn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1972Volume 77, Issue 4Page: 647-648KeywordsPsychosesSchizophrenia ePublished: 1 December 2008 Issue Published: 1 October 1972 PDF downloadLoading ...