tbuckley/cabot-search huggingface dataset:
Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages.
Authors: P Cullen, A Cignarella, B Brennhausen, S Mohr, G Assmann, A von Eckardstein
Journal: Journal of Clinical Investigation (1998)

In this study, we investigated the impact of the common apoE polymorphism on apoE metabolism and cholesterol homeostasis in monocyte-derived macrophages isolated from E2/2, E3/3, and E4/4 subjects. Unloaded cells of all genotypes contained similar amounts of free cholesterol, cholesteryl ester, and apoE mRNA. E3/3 cells secreted 77 and 30% more apoE than E2/2 or E4/4 cells, respectively. Pulse-chase studies confirmed that the apoE secretion rate was greatest in E3/3 and least in E2/2 cells and showed that a portion of apoE2, but not apoE3 or apoE4, was degraded intracellularly. Surface binding of apoE was greatest in E4/4 cells, as revealed by heparinase treatment. On cholesterol loading with acetylated LDL, apoE mRNA levels and protein secretion rose most in E4/4 and least in E2/2 cells. Cholesterol and cholesteryl ester content, however, rose most in E2/2 and least in E3/3 cells. Incubations with 3H-cholesterol-labeled acetylated LDL revealed that E2/2 cells were most efficient at secreting cholesterol. The greatest reuptake of 3H-cholesterol-rich particles was from E4/4 macrophage- conditioned media. Thus, E2/2 macrophages, despite a low apoE secretion rate, are protected from cholesterol storage by apoE-mediated cholesterol efflux. In E3/3 macrophages, cholesterol accumulation is lessened by a high basal apoE secretion rate. E4/4 macrophages secrete the most apoE but lack effective net cholesterol efflux due to enhanced surface binding and reuptake of cholesterol-rich particles.
Audit in general practice.
Authors: D. H. Metcalfe
Journal: BMJ (1989)

actionbut the debate will then have moved away from fundamental scientific issues concerning the genesis of mental states.This view, which is close to what is often termed the social concept of disease, brings its own difficulties, and until these are resolved no one is in a strong position to pronounce on the definition of mental health.The approach nevertheless has certain advantages, including its recognition of the arbitrary way in which conditions are designated as requiring to be prevented or treated.There is a large measure of agreement about these, as reflected in standard taxonomies such as the International Classification of Diseases.Yet even that distinguished publication includes some rule of thumb decisions.Few would doubt that patients with schizophrenia or Alzheimer's disease fall outside the rubric of the healthy, but with the common neuroses or personality disorders we are dealing with extremes of distributions rather than categorical distinctions.In such cases-as with, say, hypertension-the dividing line must be based on informed judgment rather than logic.A solution of this kind may be untidy, yet it may serve us best for practical purposes.Assuming, then, that we have provisionally identified the condition we wish to tackle and are fortified by some extensive epidemiological knowledge of psychiatric disorder, the next
Glucose Tolerance and Serum Insulin in Identical Twins of Diabetics
Authors: D. A. Pyke, J. Cassar, J. Todd, K. W. Taylor
Journal: BMJ (1970)

Glucose tolerance with serum insulin assay has been carried out in 24 apparently unaffected identical twins of diabetics. Glucose values were significantly higher and insulin values significantly lower than in control subjects, but there was considerable individual variation and in half the cases glucose tolerance was normal. There was no case of increased insulin response. In these twins glucose tolerance and insulin response were not correlated with weight, family history of diabetes, age at diagnosis of diabetes in the affected twin, time since that diagnosis, nor with age at testing the unaffected twin. On retesting 12 of the twins after two years no significant differences were found from the first testing.We conclude that not all these twins are likely to develop diabetes, that the assumption that identical twins of diabetics are necessarily "prediabetic" is probably erroneous, and that factors other than genetic ones are important in the aetiology of diabetes.
After the Ball: How America Will Conquer Its Fear and Hatred of Gays in the 90's
Authors: Mary A. Hartshorn
Journal: JAMA (1990)

Published in late June 1989, this book about discrimination against male homosexuals (and, to a lesser extent, lesbians) offers a practical series of suggestions (including a "Waging Peace" advertising campaign and creation of an ethical code of behavior for the gay community) to decrease such discrimination in the decade ahead; to wit, the subtitle. The authors come from interesting backgrounds: Madsen has taught communications at Harvard and has written advertising copy; Kirk is, by implication, "unfinished," but has done a variety of interesting things, such as studying neuropsychology and crafting aptitude tests for people with 200 + IQs. In the acknowledgments, both men give an interesting perspective on the business of coauthoring a controversial book while still remaining friends: "Someone's opinion must always prevail.... The real fun starts... when... we begin shifting the blame as to who said what." The book is divided into "Problems" (of discrimination
Do we need to treat vulvovaginitis in prepubertal girls?
Authors: Manohara Joishy, Chetan Sandeep Ashtekar, Arpana Jain, Rohini Gonsalves
Journal: BMJ (2005)

Vulvovaginitis is generally considered to be the commonest gynaecological problem in prepubertal girls, 1 although the incidence is unknown.In practice, the terms vulvitis, vaginitis, and vulvovaginitis are often used interchangeably by doctors in diagnosing inflammatory conditions of the lower female genital tract. 2 Diagnosing infection is confounded by the overlap between normal flora and potential pathogens.The presence of an organism does not itself denote causation, and the clinical picture as well as microbiology should be considered before infection is assumed. 1 3 Despite vulvovaginitis being a common problem, the initial management is mostly empirical, and antibiotics are commonly prescribed.In this review, we present available evidence on the management of vulvovaginitis focusing mainly on the microbiology. Search strategy and selectionWe made electronic literature searches with Medline (January 1965 to June 2004) and the Cochrane database to identify articles related to the aetiology and management of vulvovaginitis using the key words "vulvovaginitis and (prepubertal or premenstrual girls)."We limited our search to English language articles about children.We reviewed the abstracts of retrieved articles and obtained the full texts of relevant articles.We also reviewed the references of these articles.We excluded studies including pubertal girls.
Limited Restoration of Cystic Fibrosis Lung Epithelium<i>In Vivo</i>with Adult Bone Marrow–derived Cells
Authors: Roberto Loi, Travis Beckett, Kaarin K. Goncz, Benjamin T. Suratt, Daniel J. Weiss
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Rationale: Recent literature suggests that adult bone marrow–derived cells can localize to lung and acquire immunophenotypic characteristics of lung epithelial cells. We speculated this might be a potential therapeutic approach for correcting defective lung epithelium in cystic fibrosis.Objective: To determine whether adult bone marrow–derived cells containing normal cystic fibrosis transmembrane conductance regulator protein (CFTR) could repopulate lung epithelium in transgenic mice deficient in that protein.Methods: Stromal marrow cells or total marrow obtained from adult male wild-type mice were transplanted into adult female Cftr knockout mice. To increase marrow cell recruitment naphthalene was used to induce airway epithelial injury in recipient mice.Measurements and Main Results: At 1 wk, 1 mo, and 3 mo after transplantation, Cftr mRNA was detected in lung homogenates of recipient mice by reverse transcription–polymerase chain reaction. Cftr mRNA was not found in either donor marrow cells or mature circulating leukocytes. In situ examination of recipient mouse lungs demonstrated rare (0.025%) chimeric airway epithelial cells, some of which (0.01%) expressed CFTR protein. Naphthalene-induced airway remodeling nonsignificantly increased the number of chimeric airway epithelial cells expressing Cftr.Conclusions: These results demonstrate that adult marrow cells can be recruited to airway epithelium and induced to express Cftr in mice otherwise lacking this protein. However, the number of observed chimeric epithelial cells is small and new strategies for enhancing airway epithelial remodeling by adult bone marrow–derived cells will be necessary for correction of defective CFTR-dependent chloride transport.
SSA and SSB antibodies are important in the formation of circulating immune complexes in SLE
Authors: E Ahlin, L Mathsson, M-L Eloranta, L Ronnblom, J Ronnelid
Journal: Annals of the Rheumatic Diseases (2010)

The authors have earlier demonstrated that the amounts of circulating immune complexes (CIC) are higher in anti-SSA positive as compared to anti-SSA negative systemic lupus erythematosus (SLE) patients. As the same discrepancy was not found for anti-DNA, the authors hypothesised that anti-SSA but not anti-DNA might form CIC during active SLE. Here the authors have used two techniques to study the autoantibody content in CIC.

Immune complex were either isolated from SLE sera by …
Ethical Guidelines for Physician Compensation Based on Capitation
Authors: S D Pearson, J E Sabin, E J Emanuel
Journal: New England Journal of Medicine (1998)

There is a growing crisis of confidence in managed care. Because of its success in controlling costs to employers, managed care has triggered fears that necessary health services are being withheld and that decisions about health care are being driven by the financial bottom line. The growth of for-profit managed-care corporations has fanned the flames of this distrust.1 Managed-care organizations have been accused of withholding necessary services through several mechanisms, including restriction of access to specialists, denial of coverage for new forms of technology, and administrative review of physicians' decisions. But perhaps even more important, there are public fears about . . .
PSEUDO (?) OR MODIFIED (?) SMALLPOX.
Authors: T. J. HAPPEL
Journal: JAMA (1900)

The diversity of opinions in regard to the eruptive disease that has prevailed throughout the United States during 1899, has atracted much attention. My having had a personal experience with at least two hundred cases in one of the large counties of Tennessee (Gibson), and a nominal supervision of fully one hundred more as county health officer, has induced me to report this epidemic as briefly as possible. My sole object is to provoke a discussion, in which we should be deeply interested, as smallpox has been regarded with no favor by medical men. <h3>SOME FEATURES OF VARIOLA VERA.</h3> Before entering directly upon the phase of the subject presented in this paper, I desire to review briefly some of the chief characteristics of variola vera. It has been defined as an acute contagious and infectious disease, communicable at any time from the first rise in temperature to the final desquamation
BRD7 Regulates XBP1s’ Activity and Glucose Homeostasis through Its Interaction with the Regulatory Subunits of PI3K
Authors: Sang Won Park, Hilde Herrema, Mario Salazar, Isin Cakir, Serkan Cabi, Fatma Basibuyuk Sahin, Yu-Hsin Chiu, Lewis C. Cantley, Umut Ozcan
Journal: Cell Metabolism (2014)
The liver. Biology and Pathobiology. Ed 3. Edited by Irwin M. Arias, James L. Boyer, Nelson Fausto, William B. Jacoby, David Schachter, and David A. Shafritz. 1628 pp. New York: Raven, 1994. $265
Authors: Caroline A. Riely, Alexander S. Petrides
Journal: Hepatology (1995)
Treatment of cutaneous calcinosis in CREST syndrome by extracorporeal shock wave lithotripsy
Authors: Agnès Sparsa, Nicolas Lesaux, Emmanuel Kessler, Jean-Marie Bonnetblanc, Sophie Blaise, Valérie Lebrun-Ly, Pierre Colombeau, Elisabeth Vidal, Christophe Bédane
Journal: Journal of the American Academy of Dermatology (2005)
Traumatic Aortic-Right Ventricular Fistula
Authors: James A. Nowlan
Journal: JAMA (1962)

AORTIC-RIGHT VENTRICULAR fistula, an uncommon lesion, is rarely the result of a penetrating wound of the heart. Such fistulas are characterized by peripheral signs suggestive of aortic insufficiency, the appearance of a continuous murmur, and the rapid development of right ventricular failure. Prior to the development of techniques which now permit surgical repair under direct vision, the clinical course of a patient with a communication between the aortic root and right ventricle was usually fatal, but in recent years 4 traumatic aortic-right ventricular fistulas have been successfully repaired. I We recently observed an aortic-right ventricular fistula which resulted from a stab wound. Report of a Case On May 13, 1961, at 4:00a.m., a 36-year-old male laborer was admitted to Cook County Hospital with a stab wound of the left anterior chest. He was in profound shock and an infusion of phenylephrine in 5% dextrose and water was started immediately.
Assessing pain in non-intubated critically ill patients unable to self report: an adaptation of the Behavioral Pain Scale
Authors: Gérald Chanques, Jean-François Payen, Grégoire Mercier, Sylvie de Lattre, Eric Viel, Boris Jung, Moussa Cissé, Jean-Yves Lefrant, Samir Jaber
Journal: Intensive Care Medicine (2009)
Novel non-steroidal p160 coactivator interactions in tamoxifen resistant breast cancer.
Authors: M McIlroy, D McCartan, S Early, AD Hill, LS Young
Journal: Cancer Research (2009)

Abstract Abstract #3038 While most breast cancer patients initially respond to endocrine therapy, 30-40% of cases relapse within 5 years of treatment. Translational studies from our group and others have provided substantial evidence of a significant role for p160 family of Steroid Receptor Co-activator (SRC) proteins in the development of resistance to endocrine therapy. In this study we have investigated novel non-steroidal SRC-1 interactions in endocrine resistant breast cancer.&amp;#x2028; A mass-spectrometry-based screen was used to identify proteins which differentially interact with SRC-1 in endocrine resistant compared with endocrine sensitive breast cancer cells. The developmental protein, HOXC11, was confirmed as an SRC-1 interacting partner. HOXC11 was shown to be over-expressed in tamoxifen-resistant cells using immunocytochemistry and was observed to translocate to the nucleus and peri-nuclear region when cells were treated with tamoxifen. In a breast cancer TMA (n=560) HOXC11 was found to correlate with disease recurrence and metastasis (local and distant). Moreover, in addition to associating with SRC-1, HOXC11 was found to be a strong predictor of reduced disease-free survival on endocrine treatment (Hazard ratio: 5.79; p&amp;lt;0.0001).&amp;#x2028; Bioinformatic analysis identified S100β as a target gene of the HOXC11 transcription factor. Interestingly, the s100 family of calcium binding proteins has been associated with poor outcome and reduced disease-free survival in melanoma. Reporter assays were used to confirm HOXC11 as a mediator of S100β transcription. Regulation of the target gene in the presence of tamoxifen was shown to be modified by activation of protein kinase A (PKA) which has previously been implicated in the enhancement of tamoxifenÂs agonist profile. Here we have defined HOXC11 as a non-steroidal interacting partner of SRC-1; furthermore, this interaction appears to be regulated by the activation of PKA. HOXC11 expression in our breast cancer patient cohort associated with poor survival and the development of metastatic disease. This study provides evidence of a novel mechanism at play in endocrine resistant breast cancer cells. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3038.
PREDICTION OF CARDIAC RESYNCHRONIZATION THERAPY RESPONSE - VALUE OF CARDIAC 123-IODINE META-IODOBENZYLGUANIDINE IMAGING
Authors: See Hooi Ewe, Mark J. Boogers, Petra Dibbets-Schneider, Rutger J. van Bommel, Matteo Bertini, Victoria Delgado, Arnold C.T. Ng, Dominique Auger, Tomasz G. Witkowski, Imad Al Younis, Bernies van der Hiel, Martin J. Schalij, Ernst E. van der Wall, Jeroen J. Bax
Journal: Journal of the American College of Cardiology (2011)
A Diagnostic Test for "Gilbert's Disease."
Authors: J. T. Galambos
Journal: Annals of Internal Medicine (1963)

s1 April 1963A Diagnostic Test for "Gilbert's Disease."J. T. Galambos, M.D. (Associate), J. R. McLaren, M.D.J. T. Galambos, M.D. (Associate)Search for more papers by this author, J. R. McLaren, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-724_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIntravenously administered 1-131 iodipamide (R.I.I.) is rapidly concentrated in the normal human liver. External monitoring of hepatic radioactivity for 15 minutes following intravenous injection of R.I.I, is a simple, reliable, and discriminating clinical liver function test. We have shown that patients as well as animals with liver damage have a depressed hepatic uptake of R.I.I. It has also been shown that 1-131 labeled rosebengal (RIRB) uptake is also depressed in the presence of liver disease. Gilbert's disease is diagnosed in patients who have recurrent indirect hyperbilirubinemia, usually under 5 mg/100 ml, by demonstrating normal liver morphology or biopsy, normal liver... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Ga. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 724-724KeywordsBiopsyIntravenous injectionsLiverLiver diseasesLiver function tests ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
A CASE OF RAT-BITE FEVER TREATED SUCCESSFULLY BY INJECTIONS OF NOVARSENOBILLON
Authors: G. C. Low, R. P. Cockin
Journal: BMJ (1918)

RA-IEFVRMEDICAL JOURNAL 23 bas been adopted partly for convenience of argument, but largely because tllis explanation seemns plausible.Tlhe fact that the auiaesthesia in two of the cases extended wvell above ti e wouud hias led to the suggestion that it is of a functioi al nature.But even if we call it functional, does that carry us aily furtlher?Several controls lhave been tried, and patients with fractures, wounded joints, and otther bad wounds of the limbs were tested, but in no case vas a stocking anaestlhesia discovered except in tllose wlho [lad arterial lesions.Wlhatever tlle cause of the paralysis may be in these cases, it can hardly be attributed to ischaeinia.In this connexion, it may be well to recall the cerebral dis- turbaiices whiclh are apt to follow sudden obliteration, by Dperation or otherwise, of thle lumen of the common carotid or internal carotid artery.These disturbances, severe and not rarely fatal, surely cannot be attributed to isclhaemia, seeing what a liberal provision of collateral clhannels is present for supplying the brain witlh blood, and considering also the rapidity with wlicih the cerebral symptoms develop.CASE XII.Pte.0. K., wounded on September 1st, 1916, was admitted on September 9th.He had been shot through the right neck.He stated that his left arm became paralysed at the instant he was hit; in fact, he thought the wound was in his arm.The pro- jectile had clearly divided the internal carotid artery.
Hyperlipemia and alcoholic cirrhosis
Authors: H. T. Rickets
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
101 HUMAN MONOCLONAL ANTIBODIES TARGETING SR-BI PREVENT HCV ENTRY AND VIRAL SPREAD IN VIVO
Authors: P. Meuleman, M.T. Catanese, L. Verhoye, I. Desombere, C.T. Jones, H. Walter, K. Grzyb, R. Cortese, C.M. Rice, G. Leroux-Roels, A. Nicosia
Journal: Journal of Hepatology (2011)
Imatinib in Philadelphia chromosome‐positive chronic phase CML patients: Molecular and cytogenetic response rates and prediction of clinical outcome
Authors: Philipp le Coutre, Karl‐Anton Kreuzer, Il‐Kang Na, Michaela Schwarz, Joachim Lupberger, Matthias Holdhoff, Gökben Baskaynak, Harald Gschaidmeier, Uwe Platzbecker, Gerhard Ehninger, Witold Prejzner, Dieter Huhn, Christian A. Schmidt
Journal: American Journal of Hematology (2003)

Abstract Previous clinical trials with the tyrosine kinase inhibitor imatinib in chronic‐phase Philadelphia chromosome‐positive chronic myelogenous leukemia (CML) resulted in 95% of hematologic and 60% major cytogenetic remissions in patients who failed a previous interferon‐α‐containing regimen. In an identical clinical trial setting with 39 chronic‐phase CML patients we achieved comparable cytogenetic response rates after a median follow up of 30.1 weeks, with an almost identical toxicity profile. In order to identify predictive markers for the therapeutical use of imatinib, we monitored apart from standard hematology parameters bcr/abl fusion transcripts by quantitative real‐time fluorescence RT‐PCR. As previous investigations demonstrated that the plasma protein α‐1 acid glycoprotein might inactivate circulating levels of free imatinib by protein binding with high affinity, we assessed plasma α‐1 acid glycoprotein concentrations in our study cohort as well. Median bcr/abl fusion transcripts declined gradually over the entire treatment period and became significantly lowered at month 3 after initiation of imatinib therapy. Further, we observed elevated pretreatment levels of α‐1 acid glycoprotein in patients who relapsed with leukemia, whereas initial bcr/abl mRNA copy numbers were not of predictive value. In addition, we provide data showing molecular response to this therapy in the vast majority of patients. Finally, our results support the hypothesis, that initially elevated plasma levels of α‐1 acid glycoprotein might serve as a predictive marker for the clinical outcome of treatment with imatinib. Am. J. Hematol. 73:249–255, 2003. © 2003 Wiley‐Liss, Inc.