tbuckley/cabot-search huggingface dataset:
Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma
Authors: L. G. Sensi, F. Marcucci, E. Migali, G. Coniglio
Journal: Allergy (2001)

After allergen exposure, IgE-bearing mast cells surface in respiratory mucosa. Eosinophils are also recruited locally by chemotactic mediators; they are the main cell directly involved in the late phase of allergic inflammation. IgE antibody and eosinophil cationic protein (ECP) are routinely determined mainly in serum although they exert their pathogenetic role more directly on mucosal surfaces.We performed a comparative study of IgE antibody to grass and ECP on nasal mucosa and blood samples in order to evaluate the relevance of monitoring allergic inflammation in the target organ. Thirty-one patients and 10 nonatopic controls were enrolled in the protocol. Twenty-six subjects allergic to grass, 11 with rhinitis (group 1) and 15 with asthma and rhinitis (group 2), completed the study. Five patients dropped out. Specific IgE to grass and ECP was determined in nasal mucosa by our method based on in situ incubation.Serum IgE to grass did not increase during the pollen peak, as did nasal IgE, in group 1 from before the pollen peak, from 2.3 to 3.2 kU/l (P=0.02), and in group 2 at the pollen peak, from 4.8 to 12.2 kU/l (P=0.01). Serum ECP did not show any significant variation in group 1, but it increased at pollen peak from 6 to 11.2 microg/l (P=0.01) in group 2. Nasal ECP increased significantly in both groups even before the pollen peak. In group 1, ECP values rose from 15 to 39.9 microg/l (P=0.01). In group 2, ECP increase was much higher than in group 1, from 9 to 213 microg/l (P=0.001). Serum eosinophils, like nasal ECP, showed a significant increase of values from before the pollen peak in both groups, without correlation with serum ECP in rhinitic patients.Both specific IgE and ECP in the nasal mucosa showed a better correlation with allergen exposure than serum evaluations. With an appropriate method, allergic inflammation may be best monitored in the nasal mucosa.
Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study
Authors: Monika A. Niewczas, Tammy L. Sirich, Anna V. Mathew, Jan Skupien, Robert P. Mohney, James H. Warram, Adam Smiles, Xiaoping Huang, Walker Walker, Jaeman Byun, Edward D. Karoly, Elizabeth M. Kensicki, Gerard T. Berry, Joseph V. Bonventre, Subramaniam Pennathur, Timothy W. Meyer, Andrzej S. Krolewski
Journal: Kidney International (2014)
α-Interferon in the treatment of chronic viral hepatitis: effects on fibrogenesis serum markers
Authors: Franco Capra, Massimo Casaril, Giovanni Battista Gabrielli, Patrizia Tognella, Arianna Rizzi, Luigi Dolci, Romano Colombari, Paolo Mezzelani, Roberto Corrocher, Giorgio De Sandre
Journal: Journal of Hepatology (1993)
A surprising hyperpigmentation of the gums and tongue
Authors: S Dell'Isola, A M Ialungo, G Starnini, P Roselli, G Ghittoni, E Caturelli
Journal: Gut (2008)

A 33-year-old caucasian woman with chronic hepatitis C (genotype 1b) started treament with pegylated interferon α2b 80 mg plus oral ribavirin 800 mg daily. …
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
Authors: Michael A van Es, Paul WJ van Vught, Hylke M Blauw, Lude Franke, Christiaan GJ Saris, Ludo Van Den Bosch, Sonja W de Jong, Vianney de Jong, Frank Baas, Ruben van't Slot, Robin Lemmens, Helenius J Schelhaas, Anna Birve, Kristel Sleegers, Christine Van Broeckhoven, Jennifer C Schymick, Bryan J Traynor, John HJ Wokke, Cisca Wijmenga, Wim Robberecht, Peter M Andersen, Jan H Veldink, Roel A Ophoff, Leonard H van den Berg
Journal: Nature Genetics (2007)
Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infection
Authors: Stephen A. Villano, David Vlahov, Kenrad E. Nelson, Sylvia Cohn, David L. Thomas
Journal: Hepatology (1999)

The purpose of this investigation was to prospectively characterize acute hepatitis C virus (HCV) infections and to evaluate the hypothesis that the outcome is affected by identifiable clinical or viral factors. One hundred forty-two people with a history of illicit drug use who were HCV antibody-negative in 1988 were followed semiannually through 1996. HCV seroconversion (second generation enzyme immunoassay and recombinant immunoblot assay) was recognized in 43 (30%) of the participants, who were followed up for a median of 72 months. HCV RNA was detected and quantified by polymerase chain reaction in a median of 10 specimens per participant and showed two distinct patterns of viremia: viral clearance was noted in 6 (14%) of the participants, and viral persistence was observed in 37 (86%) of the participants. Subjects with viral clearance were more likely to be white (P =.004), have jaundice (P =.03), and have lower peak viral titer (P =.003). However, the outcome for a given person could not be predicted by clinical features, RNA level, or HCV subtype (as ascertained by analysis of core-E1 complementary DNA sequence). No acute infections were recognized by health care providers. At the time of seroconversion, HCV RNA was detectable in 81% of participants, and recombinant immunoblot assay (RIBA) was positive in 85% of participants. We conclude that approximately 85% of people with acute hepatitis C develop persistent viremia. However, acute infections are uncommonly recognized clinically, underscoring the importance of screening individuals at risk. Long-term follow-up, but no single laboratory test, is necessary to ascertain the outcome and in some cases make the diagnosis of acute HCV infection.
Role of transforming growth factor B (TGF-B) in hepatic fibrosis of non-alcoholic steatohepatitis (NASH) patients
Authors: Javier Crespo, Amalia Cayon, Marta Mayorga, Agustin Dominguez-Diez, Manuel Hernandez-Guerra, Pedro Fernandez-Gil, Fernando Pons-Romero
Journal: Journal of Hepatology (2002)
Polyclinics open till 10 pm proposed for London
Authors: Michael Day
Journal: BMJ (2007)

The UK government has announced a review of the NHS in a bid to ensure that clinical priorities and local accountability are paramount in the health service's day to day operations.The health secretary, Alan Johnson, has asked the junior health minister and surgeon Sir Ara Darzi to lead the review and to consult widely with patients and staff.The move is widely seen as a bid to mend relationships with health professionals, many of whom feel aggrieved by a decade of nonstop NHS reforms.Mr Johnson said that providing more accessible and convenient care for patients; achieving better value for money; and ensuring that people with long term illness were "treated with dignity in safe, clean environments" were all key areas that the review would look at.He also announced an extra £50m (€74m; $100m) to fight hospital acquired infections.Mr Johnson said, "The past 10 years have seen huge improvements in the NHS, and thanks to record investment and measures to raise standards, nine out of 10 patients rate their care as good to excellent."He added, "What was right for the last decade-top down targets and important but sometimes difficult reforms-will not be right for the next, where more local decision making and staff empowerment need to drive the NHS."He said that the review could result in an NHS constitution that sets out its values and lines of accountability.The full report will be published in June 2008.An interim assessment in autumn 2007 will inform the next comprehensive spending review.Gill Morgan, chief executive of the NHS Confederation, said, "We hope that this is not just another review but a genuine exercise in listening and understanding where the service has got to and where it needs to go.The opportunity to re-engage staff with the NHS reform programme is too important to be missed.
B7-2 Expressed on EL4 Lymphoma Suppresses Antitumor Immunity by an Interleukin 4–dependent Mechanism
Authors: C. Stremmel, E.A. Greenfield, E. Howard, G.J. Freeman, V.K. Kuchroo
Journal: The Journal of Experimental Medicine (1999)

For T cells to become functionally activated they require at least two signals. The B7 costimulatory molecules B7-1 and B7-2 provide the “second signal” pivotal for T cell activation. In this report, we studied the relative roles of B7-1 and B7-2 molecules in the induction of antitumor immunity to the T cell thymoma, EL4. We generated EL4 tumor cells that expressed B7-1, B7-2, and B7-1+B7-2 by transfecting murine cDNAs. Our results demonstrate that EL4–B7-1 cells are completely rejected in syngeneic mice. Unlike EL4–B7-1 cells, we find that EL4–B7-2 cells are not rejected but progressively grow in the mice. A B7-1– and B7-2–EL4 double transfectant was generated by introducing B7-2 cDNA into the EL4–B7-1 tumor line that regressed in vivo. The EL4–B7-1+B7-2 double transfectant was not rejected when implanted into syngeneic mice but progressively grew to produce tumors. The double transfectant EL4 cells could costimulate T cell proliferation that could be blocked by anti–B7-1 antibodies, anti–B7-2 antibodies, or hCTLA4 immunoglobulin, showing that the B7-1 and B7-2 molecules expressed on the EL4 cells were functional. In vivo, treatment of mice implanted with double-transfected EL4 cells with anti–B7-2 monoclonal antibody resulted in tumor rejection. Furthermore, the EL4–B7-2 and EL4–B7-1+B7-2 cells, but not the wild-type EL4 cells, were rejected in interleukin 4 (IL-4) knockout mice. Our data suggests that B7-2 expressed on some T cell tumors inhibits development of antitumor immunity, and IL-4 appears to play a critical role in abrogation of the antitumor immune response.
Clinicopathological Studies of Esophageal Carcinosarcoma: Analyses of its Morphological Characteristics Using Endoscopic, Histological, and Immunohistochemical Procedures
Authors: None Chino, None Kijima, None Shimada, None Nishi, None Tanaka, None Oshiba, None Kise, None Kenmochi, None Himeno, None Tsuchida, None Kawai, None Tanaka, None Machimura, None Tajima, None Makuuchi
Journal: Endoscopy (2000)

Carcinosarcoma of the esophagus is a rare malignant neoplasm consisting of both carcinomatous and sarcomatous components, which characteristically forms polypoid tumors.Seven carcinosarcomas were analyzed using endoscopic, histological, and immunohistochemical procedures. Endoscopically, six of the seven lesions were found to be of the protruding type, while the other one was an ulcerating tumor.In all seven cases, the carcinomatous component consisted of differentiated squamous cell carcinoma, and the sarcomatous component was spindle cell carcinoma. Histological analyses demonstrated that the majority of the protruding tumors consisted of the sarcomatous component, while the ulcerating tumor mainly consisted of squamous cell carcinoma. The Ki-67 (MIB-1) labeling index (LI) of the carcinomatous component (28.2%) did not differ significantly from that of the sarcomatous component (25.5%). The sarcomatous component showed abundant expression of type IV collagen and laminin.It is conceivable that the carcinomatous and sarcomatous components grow separately from the early stage of the tumors, and that the sarcomatous component forms a protruding tumor mass because it has abundant stroma positive for type IV collagen and laminin.
Diabetic Complications and Their Relationships to Risk Factors in a Japanese Population
Authors: Masaki Ishihara, Yaichiro Yukimura, Takashi Yamada, Ken Ohto, Kunio Yoshizawa
Journal: Diabetes Care (1984)

The relationship between diabetic complications and age, sex, duration, mode of therapy, body weight, control of blood glucose, blood pressure, and serum triglyceride and cholesterol was analyzed in a population with non-insulin-dependent diabetes in Japan. The prevalences of complications in the subjects varied from 6.5% for cerebrovascular strokes to 85.1% for sclerotic changes in retinal vessels; 35.8% of the patients had diabetic retinopathy and 19.8% had proteinuria. Univariate and multivariate analyses revealed that control of diabetes (blood glucose, mode of therapy, and duration) was closely correlated with retinopathy and proteinuria. However, blood glucose did not correlate with coronary insufficiency or cerebrovascular strokes. These macrovascular complications were related to aging and blood pressure. The data suggested that not only good glycemic control but also sufficient antihypertensive therapy was necessary for treating diabetic patients. The coefficient of determination of the risk factors was calculated for each diabetic complication. Except for sclerotic changes in retinal vessels, the coefficients were too small to fully explain the development of diabetic complications, especially for macrovascular diseases. The current data suggest that susceptibility of the individual patients to the diabetic complications is an important determinant.
β -Adrenergic Stimulation Restores Rat Lung Ability to Clear Edema in Ventilator-associated Lung Injury
Authors: F. J. SALDÍAS, E. LECUONA, A. P. COMELLAS, K. M. RIDGE, D. H. RUTSCHMAN, J. I. SZNAJDER
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Mechanical ventilation with high tidal volume (HVT) causes lung injury and decreases the lung's ability to clear edema in rats. beta-adrenergic agonists increase active Na(+) transport and lung edema clearance in normal rat lungs by stimulating apical Na(+) channels and basolateral Na,K-ATPase in alveolar epithelial cells. We studied whether beta-adrenergic agonists could restore lung edema clearance in rats ventilated with HVT (40 ml/kg, peak airway pressure of 35 cm H(2)O) for 40 min. The ability of rat lungs to clear edema decreased by approximately 50% after 40 min of HVT ventilation. Terbutaline (TERB) and isoproterenol (ISO) increased lung edema clearance in control nonventilated rats (from 0.50 +/- 0. 02 ml/h to 0.81 +/- 0.04 ml/h and 0.99 +/- 0.05 ml/h, respectively) and restored the lung's ability to clear edema in HVT ventilated rats (from 0.25 +/- 0.03 ml/h to 0.64 +/- 0.02 ml/h and 0.88 +/- 0. 09 ml/h, respectively). Disruption of cell microtubular transport system by colchicine inhibited the stimulatory effects of ISO in HVT ventilated rats, whereas beta-lumicolchicine did not affect beta-adrenergic stimulation. The Na,K-ATPase alpha(1)- and beta(1)-subunit mRNA steady state levels were not affected by incubation with ISO for 60 min in alveolar type II cells isolated from control and HVT ventilated rats. The data suggest that beta-adrenergic agonists increased alveolar fluid reabsorption in rats ventilated with HVT by promoting recruitment of ion-transporting proteins from intracellular pools to the plasma membrane of alveolar epithelial cells.
RECENT ADVANCES IN THE TREATMENT OF DIABETES MELLITUS
Authors: GEORGE B. WALLACE
Journal: JAMA (1910)

stated that there is no diminution in the total energy production of the diabetic as compared with the normal man.The diabetic obtains his calorific energy from fat instead of from carbohydrates, and if fat is not given him in sufficient quantity to maintain his requirement he uses his own body fat.Pettenkofer and Voit in early experiments on a dia¬ betic found no change in the metabolism from the normal.Rubner, using a phlorhizinized dog, found that the heat production was increased by 7 per cent, when glycosuria was induced.The protein metabolism was increased more than threefold,.and he attributed the rise in energy production to the increased protein destruction (specific dynamic action of protein).Palta/ working with Benedict in Boston, could find do evidence of an increased metabolism in diabetes mellitus.Du Bois andVeeder" report a comparison betw.i the metabolism of a normal man and two men suffering from diabetes.One case, which was of the most severe type of diabetes, showed an increase in metabolism of 5 per cent, above the normal.Finally, -a preliminary report by F. G.Benedict and E. P. Joslin of work on the metabolism of thirteen patients representing various types of diabetes, .declaresthat the heal production of the diabetic may be 15 per cent, above the normal.Zuntz attributes this rise
Effects of Identifying a High Risk Population
Authors: Steven G Gabbe
Journal: Diabetes Care (1980)

Gestational diabetic women who are at greater risk for perinatal loss include those patients with the history of a previous intrauterine death, an elevated fasting glucose level, pregnancy-induced hypertension, or prolonged gestation. These patients do require a program of antepartum fetal surveillance to prevent intrauterine deaths. Within the broad category of gestational diabetes, however, another group of patients may be defined who can be followed safely to term with no higher perinatal mortality than that observed in the general population. Such women have been designated Class A diabetic by White, indicating that they have normal fasting glucose levels, an abnormal oral glucose tolerance test, and require only minimal dietary regulation. Fasting glucose levels must be followed closely in Class A patients to detect those who develop overt diabetes.
MicroRNA-93 Controls Perfusion Recovery After Hindlimb Ischemia by Modulating Expression of Multiple Genes in the Cell Cycle Pathway
Authors: Surovi Hazarika, Charles R. Farber, Ayotunde O. Dokun, Achillieas N. Pitsillides, Tao Wang, R. John Lye, Brian H. Annex
Journal: Circulation (2013)

Background— MicroRNAs are key regulators of gene expression in response to injury, but there is limited knowledge of their role in ischemia-induced angiogenesis, such as in peripheral arterial disease. Here, we used an unbiased strategy and took advantage of different phenotypic outcomes that follow surgically induced hindlimb ischemia between inbred mouse strains to identify key microRNAs involved in perfusion recovery from hindlimb ischemia. Methods and Results— From comparative microRNA profiling between inbred mouse strains that display profound differences in their extent of perfusion recovery after hindlimb ischemia, we found that the mouse strain with higher levels of microRNA-93 (miR-93) in hindlimb muscle before ischemia and the greater ability to upregulate miR-93 in response to ischemia had better perfusion recovery. In vitro, overexpression of miR-93 attenuated hypoxia-induced apoptosis in both endothelial and skeletal muscle cells and enhanced proliferation in both cell types. In addition, miR-93 overexpression enhanced endothelial cell tube formation. In vivo, miR-93 overexpression enhanced capillary density and perfusion recovery from hindlimb ischemia, and antagomirs to miR-93 attenuated perfusion recovery. Both in vitro and in vivo modulation of miR-93 resulted in alterations in the expression of &gt;1 cell cycle pathway gene in 2 different cell types. Conclusions— Our data indicate that miR-93 enhances perfusion recovery from hindlimb ischemia by modulation of multiple genes that coordinate the functional pathways of cell proliferation and apoptosis. Thus, miR-93 is a strong potential target for pharmacological modulation to promote angiogenesis in ischemic tissue.
The Scientific Status of Childhood Dissociative Identity Disorder: A Review of Published Research
Authors: Guy A. Boysen
Journal: Psychotherapy and Psychosomatics (2011)

&lt;i&gt;Background:&lt;/i&gt; Dissociative identity disorder (DID) remains a controversial diagnosis due to conflicting views on its etiology. Some attribute DID to childhood trauma and others attribute it to iatrogenesis. The purpose of this article is to review the published cases of childhood DID in order to evaluate its scientific status, and to answer research questions related to the etiological models. &lt;i&gt;Methods:&lt;/i&gt; I searched MEDLINE and PsycINFO records for studies published since 1980 on DID/multiple personality disorder in children. For each study I coded information regarding the origin of samples and diagnostic methods. &lt;i&gt;Results:&lt;/i&gt; The review produced a total of 255 cases of childhood DID reported as individual case studies (44) or aggregated into empirical studies (211). Nearly all cases (93%) emerged from samples of children in treatment, and multiple personalities was the presenting problem in 23% of the case studies. Four US research groups accounted for 65% of all 255 cases. Diagnostic methods typically included clinical evaluation based on Diagnostic and Statistical Manual of Mental Disorder criteria, but hypnosis, structured interviews, and multiple raters were rarely used in diagnoses. &lt;i&gt;Conclusion:&lt;/i&gt; Despite continuing research on the related concepts of trauma and dissociation, childhood DID itself appears to be an extremely rare phenomenon that few researchers have studied in depth. Nearly all of the research that does exist on childhood DID is from the 1980s and 1990s and does not resolve the ongoing controversies surrounding the disorder.
SEQUEL OF A CASE OF TROPHIC DISORDER OF THE FEET
Authors: F. PARKES WEBER
Journal: British Journal of Dermatology (1902)

Journal Article SEQUEL OF A CASE OF TROPHIC DISORDER OF THE FEET Get access F. PARKES WEBER, M.D., F.R.C.P. F. PARKES WEBER, M.D., F.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 14, Issue 10, 1 October 1902, Pages 388–392, https://doi.org/10.1111/j.1365-2133.1902.tb16414.x Published: 01 October 1902
Does Being Natural Make It Good?
Authors: Helen B. Hiscoe
Journal: New England Journal of Medicine (1983)

How many ads try to seduce the buyer with the appeal, "Our product is 100 per cent natural"? The product may be a food, a cosmetic, or even a fabric. Health-food stores prosper because of our love affair with nature. Foods that are grown 100 per cent organically command higher prices than those nurtured by chemical fertilizers and pesticides (as if a plant could care about the source of the appropriate molecule). The back-to-nature movement inspires some women to prefer natural childbirth over birth with professional assistance (sometimes in spite of risk to themselves and their infants). It may underlie . . .
Impairment in endothelial‐dependent forearm vasodilation in idiopathic cardiomyopathy is related to severe left ventricle dilation and elevated serum tumor necrosis factor levels
Authors: M. Sitges, M. Morales, M. Azqueta, E. Roig, F. Pérez‐Villa, C. Paré, J. Orús, M. Heras
Journal: European Journal of Heart Failure (2000)
Long-term WT1 peptide vaccination for patients with acute myeloid leukemia with minimal residual disease
Authors: A Tsuboi, Y Oka, T Kyo, Y Katayama, O A Elisseeva, M Kawakami, S Nishida, S Morimoto, A Murao, H Nakajima, N Hosen, Y Oji, H Sugiyama
Journal: Leukemia (2011)