tbuckley/cabot-search huggingface dataset:
594 ERYTHROID DIFFERENTIATION IS SUPPRESSED BY RIBAVIRIN DURING COMBINATION THERAPY WITH PEGYLATED INTERFERON-α2a IN CHRONIC HEPATITIS C: AN IN VITRO AND IN VIVO STUDY
Authors: A. Aghemo, L. Ronzoni, M.G. Rumi, G.M. Prati, S. Monico, A. Colancecco, P. Grillo, M. Viganó, M.D. Cappellini, M. Colombo
Journal: Journal of Hepatology (2009)
Learning from indigenous people
Authors: R. Smith
Journal: BMJ (2003)

health, as well as emphasising the role of individuals in changing their lifestyles and health habits.Bloomfield and Logan (p 439) argue that a quality improvement framework is a better approach to healthcare priority setting and funding decisions than is the explicit prioritisation processes that have recently taken place in New Zealand.McPherson and colleagues (p 443) show how developments at national and local levels have reduced the disparities in life expectancies and health among indigenous people in New Zealand.On p 445 Cunningham and colleagues discuss the tripartite memorandum of understanding on indigenous health research signed by Australia, Canada, and New Zealand, which aims to share information and expertise on health research funding.
Exercise Training Stimulates Ischemia-Induced Neovascularization via Phosphatidylinositol 3-Kinase/Akt-Dependent Hypoxia-Induced Factor-1α Reactivation in Mice of Advanced Age
Authors: Xian Wu Cheng, Masafumi Kuzuya, Weon Kim, Haizhen Song, Lina Hu, Aiko Inoue, Kae Nakamura, Qun Di, Takeshi Sasaki, Michitaka Tsuzuki, Guo-Ping Shi, Kenji Okumura, Toyoaki Murohara
Journal: Circulation (2010)

Background— Exercise stimulates the vascular response in pathological conditions, including ischemia; however, the molecular mechanisms by which exercise improves the impaired hypoxia-induced factor (HIF)-1α–mediated response to hypoxia associated with aging are poorly understood. Here, we report that swimming training (ST) modulates the vascular response to ischemia in aged (24-month-old) mice. Methods and Results— Aged wild-type mice (MMP-2 +/+ ) that maintained ST (swimming 1 h/d) from day 1 after surgery were randomly assigned to 4 groups that were treated with either vehicle, LY294002, or deferoxamine for 14 days. Mice that were maintained in a sedentary condition served as controls. ST increased blood flow, capillary density, and levels of p-Akt, HIF-1α, vascular endothelial growth factor, Fit-1, and matrix metalloproteinase-2 (MMP-2) in MMP-2 +/+ mice. ST also increased the numbers of circulating endothelial progenitor cells and their function associated with activation of HIF-1α. All of these effects were diminished by LY294002, an inhibitor of phosphatidylinositol 3-kinase; enhanced by deferoxamine, an HIF-1α stabilizer; and impaired by knockout of MMP-2. Finally, bone marrow transplantation confirmed that ST enhanced endothelial progenitor cell homing to ischemic sites in aged mice. Conclusions— ST can improve neovascularization in response to hypoxia via a phosphatidylinositol 3-kinase–dependent mechanism that is mediated by the HIF-1α/vascular endothelial growth factor/MMP-2 pathway in advanced age.
INFECTIVE GRANULOMATA OF PHARYNX: GLANDERS.
Authors: EMMA E. MUSSON
Journal: JAMA (1899)

For the laryngologist the case to be reported will have at least two points of interest. It is, as far as I can find, a unique case of infective granulomata of throat due to the bacillus mallei. Its other point of interest lies in its microscopic and macroscopic resemblance to sarcomata of the tonsils. Virchow was the first to use the term "infective granulomata," applying it to the lesions of tubercle, lupus, syphilis, glanders, leprosy, actinomycosis and rhinoscleroma, on account of the resemblance which they show to some forms of tumor. It, however, remained for Loeffler and Schuetz, in 1882, to discover the bacillus mallei. Mrs. H. R., aged 54, married, reported to me Oct. 2, 1893, with the history of rapid enlargement of tonsils commencing twelve months ago; for the past three months they have been their present size, and for that length of time she has had much
22. Generation of Circular Sleeping Beauty DNA Transposition Substrates by RU486-Induced Flp Recombination In Vitro – Steps towards a Single Integrating Adeno-Transposon Vector
Authors: Jacob G. Mikkelsen, Stephen R. Yant, Anja Ehrhardt, Mark A. Kay
Journal: Molecular Therapy (2005)

DNA transposons, incorporated in nonviral or viral gene delivery systems, represent promising new tools for chromosomal transgene insertion and establishment of persistent gene expression in vivo. In a nonviral gene therapy approach based on a single plasmid vector containing (i) a transgene-tagged Sleeping Beauty (SB) transposon and (ii) a SB-derived transposase we have previously demonstrated efficient transposition and therapeutic gene expression in mouse liver (Mikkelsen et al., Mol. Ther. 2003, 8:654). Although this vector technology holds great promise as a nonviral therapeutic tool, incorporation of the transposon integration machinery into viral vector systems may be required for some applications. We have previously shown that circular DNA serves as an efficient substrate for SB transposition, whereas linear DNA only supports limited transposition. Therefore, to create a gutless 'all-in-one' adenoviral vector containing all components required for transposition we have generated adenoviral vector constructs from which plasmid-like circular DNA carrying a transgene-marked transposon and a transposase expression cassette can be released by Flp-recombinase-based recombination. To reduce possible premature DNA circle formation during vector preparation, we fused Flpe with a modified human progesterone receptor (hPR) domain that facilitates specific binding to and activation by the synthetic steroid RU486. By co-transfections with a |[beta]|-gal reporter plasmid, the Flpe-hPR protein was found to retain 20 to 50% of the wildtype Flpe activity (depending on cell line) in the presence of RU486 and was induced 6- to 44-fold by addition of RU486. Next, by using plasmid vectors containing both (i) a neo-tagged transposon and (ii) a Flpe-activated transposase expression cassette we found that the level of transposition in Flpe-hPR-transfected HeLa cells was 5-fold higher than the background level in the presence of RU486 and only slightly reduced (1.4-fold) compared to cells transfected with wildtype Flpe plasmid. We have successfully produced 'all-in-one' adenoviral vectors carrying the transposase coding sequence, the Flpe-hPR recombinase gene, and a human factor IX-marked transposon and are currently studying RU486-induced generation of circular substrates for SB-mediated transposition in in vitro-transduced cells. In summary, this study demonstrates a new approach for drug-inducible SB transposition and its use in a novel integrating adenoviral vector system with potential applications in gene therapy approaches which require long-term transgene expression.
Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization
Authors: Pornsak Sriamornsak, Kanokporn Burapapadh
Journal: Asian Journal of Pharmaceutical Sciences (2015)

The objective of the present study was to alter the crystal habit of itraconazole (ITZ) by cooling and anti-solvent crystallization and characterize its properties. ITZ was recrystallized in different solvents and the effects of each solvent on morphology of crystals, dissolution behavior and solid state of recrystallized drug particles were investigated. The results revealed that ITZ crystals recrystallized by cooling and anti-solvent crystallization showed the different crystal habits from the untreated ITZ. Using cooling crystallization tended to provide needle-shaped crystals while the crystals obtained from anti-solvent crystallization showed more flaky, plate shape. This indicated the importance of preparation method on nucleation and crystal growth. No change in drug polymorphism was observed, according to determination of thermal property and crystalline state by differential scanning calorimetry and powder X-ray diffractometry, respectively. The recrystallized ITZ showed higher drug dissolution than untreated ITZ and the highest drug dissolution was observed from the samples recrystallized in the presence of PEG 200, which provided the small plate-shaped crystals with tremendously increased in surface area. However, the increasing of drug dissolution is relatively small, therefore, further development may be required.
Prognostic Significance of LGE by CMR in Aortic Stenosis Patients Undergoing Valve Replacement
Authors: Gilles Barone-Rochette, Sophie Piérard, Christophe De Meester de Ravenstein, Stéphanie Seldrum, Julie Melchior, Frédéric Maes, Anne-Catherine Pouleur, David Vancraeynest, Agnes Pasquet, Jean-Louis Vanoverschelde, Bernhard L. Gerber
Journal: Journal of the American College of Cardiology (2014)
Bone Marrow Transplants from Unrelated Donors for Patients with Chronic Myeloid Leukemia
Authors: John A. Hansen, Theodore A. Gooley, Paul J. Martin, Frederick Appelbaum, Thomas R. Chauncey, Reginald A. Clift, Effie W. Petersdorf, Jerald Radich, Jean E. Sanders, Rainer F. Storb, Keith M. Sullivan, Claudio Anasetti
Journal: New England Journal of Medicine (1998)

Chronic myeloid leukemia can be cured by marrow transplantation from an HLA-identical sibling donor. The use of transplants from unrelated donors is an option for the 70 percent of patients without an HLA-identical sibling, but the morbidity and mortality associated with such transplants have been cause for concern. We analyzed the safety and efficacy of transplants from unrelated donors for the treatment of chronic myeloid leukemia and identified variables that predict a favorable outcome.
Hepatic Coma with Recovery in a Cystinuric
Authors: E. D. H. Cowen
Journal: BMJ (1951)

Effective adrenergic blocking agents able to prevent the hypertensive attacks have been described (Console et al., 1950) and their severe side-reactions discussed (Swan, 1951).Some, such as benzodiozane, act quickly and are useful in the acute hypertensive attack whether spontaneous or provoked by histamine.Others, such as " dibenamine," are slower to act but more prolonged and complete in action, and preliminary reports (Bartels and Cattell, 1950; Crowther, 1951) suggest that these probably offer the best hope of success in preparing the patient for later surgery by preventing the state of shock.We are grateful to Dr. Russell Fraser and Mr.
Right Ventricular Enlargement on Chest Computed Tomography
Authors: Rene Quiroz, Nils Kucher, U. Joseph Schoepf, Florian Kipfmueller, Scott D. Solomon, Philip Costello, Samuel Z. Goldhaber
Journal: Circulation (2004)

Background— We investigated the prognostic role of right ventricular enlargement on multidetector-row chest CT in acute pulmonary embolism (PE). Methods and Results— We studied 63 patients with CT-confirmed PE who underwent echocardiography within the ensuing 24 hours. Adverse clinical events, defined as 30-day mortality or the need for cardiopulmonary resuscitation, mechanical ventilation, pressors, rescue thrombolysis, or surgical embolectomy, were present in 24 patients. We performed off-line CT measurements of right and left ventricular dimensions (RV D , LV D ) with axial and 2-dimensional reconstructed 4-chamber (4-CH) views. The proportion of patients with RV D /LV D &gt;0.9 on the axial view was similar in patients with (70.8%) and those without adverse events (71.8%; P =0.577). In contrast, RV D /LV D &gt;0.9 on the 4-CH view was more common in patients with (80.3%) than without (51.3%; P =0.015) adverse events. The area under the curve of RV D /LV D from the axial and 4-CH views for predicting adverse events was 0.667 and 0.753, respectively. Sensitivity and specificity of RV D /LV D &gt;0.9 for predicting adverse events were 37.5% and 92.3% on the axial view and 83.3% and 48.7% on the reconstructed 4-CH view, respectively. RV D /LV D &gt;0.9 on the 4-CH view was an independent predictor for adverse events (OR, 4.02; 95% CI, 1.06 to 15.19; P =0.041) when adjusted for age, obesity, cancer, and recent surgery. Conclusions— Right ventricular enlargement on the reconstructed CT 4-CH views predicts adverse clinical events in patients with acute PE. Ventricular CT measurements obtained from 4-CH views are superior to those from axial views for identifying high-risk patients.
"Labyrinthine" commissioning is barrier to change, says NHS expert
Authors: G. Iacobucci
Journal: BMJ (2014)

New competition laws and the fragmentation of commissioning responsibilities between clinical commissioning groups and NHS England are huge barriers to change in the health service, an NHS strategist has warned.

Ruth Carnall, former chief executive of NHS London, said, “We have an absolute labyrinth of process that people need to wade through in order to get support for change. Many people live in daily fear of the judicial review that’s going to come along if they don’t follow the minutiae of the processes we’ve set up.”

She was speaking at the NHS Innovation Expo in Manchester on 3 March. Carnall, who now works as an independent healthcare consultant to the …
MICROWAVE RADIOMETRY FOR THE DETECTION OF LOCAL INFLAMMATORY ACTIVATION IN CAROTID ATHEROSCLEROTIC PLAQUES: A NEW NON-INVASIVE METHOD
Authors: Andreas Synetos, Konstantinos Toutouzas, Maria Drakopoulou, Haralampos Grassos, Konstantinos Stathogiannis, Eleftherios Tsiamis, Georgios Agrogiannis, Efstratios Patsouris, Athanasios Katsargyris, Christos Klonaris, Nikolaos Liasis, Dimitrios Tousoulis, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2012)
What “the Straw Man” Teaches Us, Or, Finding Wisdom Between the Horns of a False Dilemma About Ethics Consultation Methodology
Authors: Jeffrey P. Spike
Journal: The American Journal of Bioethics (2015)

"What "the Straw Man" Teaches Us, Or, Finding Wisdom Between the Horns of a False Dilemma About Ethics Consultation Methodology." The American Journal of Bioethics, 15(1), pp. 48–49
724-3 Long RP Tachycardia: Can Mode of Termination by Adenosine Differentiate Atrial from Atypical AV Node Re-entry Tachycardia?
Authors: John Hill, Rafe Chamberlain Webber, Leandro Zimerman, Hossein Shenasa, Richard Fogel, Marcus Wharton, Eric Prystowsky
Journal: Journal of the American College of Cardiology (1995)
GENETIC POLYMORPHISM IN HUMAN GLYCINE-RICH BETA-GLYCOPROTEIN
Authors: Chester A. Alper, Thomas Boenisch, Lillian Watson
Journal: The Journal of Experimental Medicine (1972)

Extensive polymorphism of glycine-rich beta-glycoprotein (GBG) was found in human sera. In all instances, GBG consisted of at least five components on electrophoresis. Patterns were such that they provided evidence for four alleles (at a locus designated Gb) which were expressed as autosomal codominant traits. Gb(S) and Gb(F) were found in all populations but with different frequencies, Gb(F1) was found in Negroes, and Gb(S1) was found in Caucasians. From electrophoretic studies of GBG, evidence was obtained that suggested that the GBG molecule was a tetramer consisting of A and B subunits in a proportion of about 1.6:1. The genetically controlled differences in GBG embodied in the Gb system indicated the presence of a third moiety of the molecule (C), possibly a polypeptide subunit. Electrophoretic studies of fragments from defined types of GBG suggested that GBG cleavage induced by complement or properdin activation in serum occurred through this C moiety, since two variants were detectable in one fragment and two were found in the other fragment. On comparison of fetal-maternal Gb types, approximately one-half the pairs showed differences. This indicated that GBG did not cross the placental barrier.
SI Units and Enzyme Levels
Authors: David E. Langdon
Journal: JAMA (1979)

To the Editor.—  The International System of Units (SI) (240:1618, 1978) perpetuates one of the major shackles imposed by the laboratory man on his clinical colleagues—a Tower of Babel in normal enzyme levels. Each enzyme, however rarely used, has its own normal level that has to be memorized, or a call to the laboratory is required. If different substrates are used for the same enzyme, then there are many normal levels for the same enzyme, all in SI units. The patient-related problems are numerous. Normal levels for a laboratory may change. Last month I sent a patient to an emergency room for an amylase reading; I knew the normal level to be 200. The value was 148, but one week later, I found that the normal level had been changed the week before to 28—rather devastating. When normal levels change, reading old charts is tougher than reading cuneiform—one needs to
Mercury battery ingestion.
Authors: D T Reilly
Journal: BMJ (1979)

laparotomyl or were examined post mortem.13 14An appreciable proportion of patients, however-140, in the Public Health Laboratory Service series9-had fresh blood, pus, or mucus in their stools, suggesting colorectal inflammation.The presence of proctitis in eight of the 11 patients in the present series suggested that colonic inflammation occurred commonly in those patients whose symptoms were severe enough to require hospital admission, and may have played an important part in producing the diarrhoea.It is accepted that infection with salmonella, shigella, or amoeba should be included in the differential diagnosis of irritable bowel disease, and our findings indicate that campylobacter should be considered.The changes seen on sigmoidoscopy and with a barium enema have little value in differentiating campylobacter colitis from irritable bowel disease, and, moreover, the histology of rectal biopsy specimens may show changes of this disease, thus compounding the problem.The importance of comprehensive bacteriological studies in all patients presenting with bloody diarrhoea cannot be overemphasised.Patients who in the past were diagnosed as having irritable bowel disease on clinical, sigmoidoscopic, and histological grounds may well have been suffering from unrecognised campylobacter colitis.sixth postoperative day.
All opportunities should now be taken to meet the needs of patients with learning difficulties
Authors: M. A. Hoghton, P. Heslop, A. Marriott, P. Fleming, L. Russ, P. Blair
Journal: BMJ (2013)

Hollins and Tuffrey-Wijne recently highlighted some of the key findings of the Confidential Inquiry into Premature Deaths of People with Learning Disabilities.1 We await the minister of state for care and support, Norman Lamb, and the Department of Health’s response before the end of June 2013. However, the 18 key recommendations will need sustained action from all of us involved in health and social …
Cerebral infarct associated with factor V Leiden mutation in a boy with hemophilia A
Authors: Lale Olcay, Aytemiz Gürgey, Haluk Topaloğlu, Sedat Altay, Hülya Parlak, Murat Firat
Journal: American Journal of Hematology (1997)

An 11-year-old boy with mild hemophilia A was admitted to our hospital because of focal convulsions. Magnetic resonance imaging showed an old occipital infarct. Protein C, S, antithrombin III, anticardiolipin antibodies and fibrinogen were normal. Heterozygosity for factor V Leiden mutation was detected. We suggest that factor V Leiden mutation should be studied in hemophiliacs with thrombosis. Am. J. Hematol. 56:189–190, 1997. © 1997 Wiley-Liss, Inc.
TINEA IMBRICATA IN MALAYA.*
Authors: IVAN POLUNIN
Journal: British Journal of Dermatology (1952)

Journal Article TINEA IMBRICATA IN MALAYA. Get access IVAN POLUNIN, M. A., D. M., B. SC. Oxon. IVAN POLUNIN, M. A., D. M., B. SC. Oxon. Department of Social Medicine and Public Health, University of Malaya, Singapore Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 64, Issue 10, 1 October 1952, Pages 378–384, https://doi.org/10.1111/j.1365-2133.1952.tb15801.x Published: 01 October 1952
Patient With Homer-3 Antibodies and Cerebellitis
Authors: Romana Höftberger, Lidia Sabater, Angel Ortega, Josep Dalmau, Francesc Graus
Journal: JAMA Neurology (2013)

Homer proteins are a family of scaffolding proteins of the postsynaptic density. Homer-3 colocalizes and modulates the activity of group I metabotropic glutamate receptors (mGluR1 and mGluR5). Cerebellitis has been reported in association with antibodies to mGluR1. We describe the second patient with cerebellitis and Homer-3 antibodies and report a novel, highly specific immunoblot assay.A 38-year-old man had acute onset of headache, nausea, vomiting, and confusion. He developed a pancerebellar syndrome during the ensuing week. Extensive studies did not reveal any tumor. Cerebrospinal fluid analysis showed a white blood cell count of 60/μL (to convert to ×109 per liter, multiply by 0.001). Brain magnetic resonance imaging findings were normal. For 2 years, the patient was treated with intravenous immunoglobulins and steroids, with partial improvement of the cerebellar ataxia. The patient was negative for onconeural (Hu, Yo, Ri, CV2, Tr, amphiphysin, and Ma2), glutamic acid decarboxylase, and mGluR1 antibodies. Immunohistochemistry on rat brain revealed immunostaining of the cerebellar molecular layer. Homer-3 antibodies were demonstrated by immunoblot of recombinant Homer-3. The clinical features of this patient and a previously described patient with Homer-3 antibodies are similar to those of patients with mGluR1 antibodies.We report the second case of autoimmune cerebellar ataxia associated with Homer-3 antibodies. The presence of Homer-3 autoantibodies should be considered in the differential diagnosis of patients with subacute cerebellar ataxia of unknown cause.
Need for Controlled Study
Authors: David H. Spodick
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The article by Sheldon et al on venous autografts for myocardial revascularization (<b>213</b>: 78, 1970) records a magnificent surgical series from the standpoint of concept and technical ability. Yet the very appealing evidence for success remains inconclusive. Where are the control patients? Surgery is a form of therapy, not a magical process. It must be evaluated like other treatments and by equally high standards, ie, by minimizing bias through random allocation of "qualifying" patients to control and treated groups. It is equally deplorable that in the same issue (QUESTIONS AND ANSWERS, p 135) Dr. Baue's evaluation of various forms of revascularization is devoid of any reference to the lack of control. My criticism of the surgical enthusiasts is not that they are wrong (or even probably wrong), but rather that they have not attempted to really prove themselves right. Their technical and professional expertise are not in
Coxsackie B infection and arthritis
Authors: N. R Grist, E. J Bell
Journal: BMJ (1983)

rectum at necropsy was described as ". . .much thickened in its coats, and of a hardish gristly texture, a good deal like the turtle's intestines."3Few modern human pathologists are familiar with the intestines of reptiles, and it is only relatively recently that veterinary surgeons have developed an interest in this group of animals.These and other cases exemplify Hunter's breadth of interest and experience and, at a time when there is increasing contact and cooperation between doctors and veterinary surgeons, are a timely reminder of the im- portance of comparative studies.