tbuckley/cabot-search huggingface dataset:
PSORIATIC HYPERPLASIA: SOME MEASUREMENTS
Authors: E. CHRISTOPHERS, O. BRAUN-FALCO
Journal: British Journal of Dermatology (1970)

SUMMARY.— Single psoriatic lesions were analysed planimetrically and auto-radiographically after 3H-thymidine labelling. The results indicate maximum alterations of epidermis and papillary body in the centre of a lesion. Epidermal volume values are elevated at the periphery while the papillary body is still normal. After stripping, the proliferative activity of the peripheral epidermis increases in proportion to epidermal volume, while no stimulatory effect can be exerted in the centre of a lesion. Comparison of several lesions reveals large differences for volume values and between single rete pegs for 3H-thymidine labelling. The role of an epidermal defect in evoking the changes is discussed.
6 ALL ORAL THERAPY WITH SOFOSBUVIR + RIBAVIRIN FOR 12 OR 16 WEEKS IN TREATMENT EXPERIENCED GT2/3 HCV-INFECTED PATIENTS: RESULTS OF THE PHASE 3 FUSION TRIAL
Authors: D.R. Nelson, J. Feld, K.V. Kowdley, M.T. Al-Assi, M. Lin, H. Mo, J. McNally, D.M. Brainard, W.T. Symonds, J.G. McHutchison, K. Patel, S.C. Gordon
Journal: Journal of Hepatology (2013)
EFFECTIVENESS OF A CLINICAL DECISION SUPPORT SYSTEM INCORPORATING A VALIDATED QT INTERVAL PROLONGATION RISK SCORE FOR REDUCING THE RISK OF QT INTERVAL PROLONGATION IN HOSPITALIZED PATIENTS
Authors: James Tisdale, Heather Wroblewski, Joanna Kingery, Brian Overholser, Tate N. Trujillo, Richard Kovacs
Journal: Journal of the American College of Cardiology (2012)
Child wellbeing and income inequality in rich societies: ecological cross sectional study
Authors: Kate E Pickett, Richard G Wilkinson
Journal: BMJ (2007)

Objectives To examine associations between child wellbeing and material living standards (average income), the scale of differentiation in social status (income inequality), and social exclusion (children in relative poverty) in rich developed societies. Design Ecological, cross sectional studies. Setting Cross national comparisons of 23 rich countries; cross state comparisons within the United States. Population Children and young people. Main outcome measures The Unicef index of child wellbeing and its components for rich countries; eight comparable measures for the US states and District of Columbia (teenage births, juvenile homicides, infant mortality, low birth weight, educational performance, dropping out of high school, overweight, mental health problems). Results The overall index of child wellbeing was negatively correlated with income inequality ( r =−0.64, P=0.001) and percentage of children in relative poverty ( r =−0.67, P=0.001) but not with average income ( r =0.15, P=0.50). Many more indicators of child wellbeing were associated with income inequality or children in relative poverty, or both, than with average incomes. Among the US states and District of Columbia all indicators were significantly worse in more unequal states. Only teenage birth rates and the proportion of children dropping out of high school were lower in richer states. Conclusions Improvements in child wellbeing in rich societies may depend more on reductions in inequality than on further economic growth.
Case 8-1980
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Ashby C. Moncure, John T. Fallon
Journal: New England Journal of Medicine (1980)

Presentation of CaseA 66-year-old man was admitted to the hospital because of hemoptysis.There was a long history of ischemic heart disease, with four episodes of myocardial infarction between six and 19 years earlier. Thirty-four months before admission a triple coronary-artery-bypass graft was performed elsewhere, with an aneurysmectomy of the inferior wall of the left ventricle. Exertional angina pectoris continued but was diminished in frequency and severity. Two years before admission he came to this hospital because of reflex sympathetic dystrophy of the left arm; an injection into the left stellate ganglion resulted in improvement. Two months later a . . .
Myocardial ischaemia: can we agree on a definition for the 21st century?
Authors: D. J HEARSE
Journal: Cardiovascular Research (1994)

Journal Article Myocardial ischaemia: can we agree on a definition for the 21st century? Get access DAVID J HEARSE DAVID J HEARSE Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 12, December 1994, Pages 1737–1744, https://doi.org/10.1093/cvr/28.12.1737 Published: 01 December 1994
In Vitro Fertilization and Risk of Autistic Disorder and Mental Retardation
Authors: Marcelle I. Cedars
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Challenges Facing Early Career Academic Cardiologists
Authors: Carl W. Tong, Tariq Ahmad, Evan L. Brittain, T. Jared Bunch, Julie B. Damp, Todd Dardas, Amalea Hijar, Joseph A. Hill, Anthony A. Hilliard, Steven R. Houser, Eiman Jahangir, Andrew M. Kates, Darlene Kim, Brian R. Lindman, John J. Ryan, Anne K. Rzeszut, Chittur A. Sivaram, Anne Marie Valente, Andrew M. Freeman
Journal: Journal of the American College of Cardiology (2014)

Early career academic cardiologists currently face unprecedented challenges that threaten a highly valued career path. A team consisting of early career professionals and senior leadership members of American College of Cardiology completed this white paper to inform the cardiovascular medicine profession regarding the plight of early career cardiologists and to suggest possible solutions. This paper includes: 1) definition of categories of early career academic cardiologists; 2) general challenges to all categories and specific challenges to each category; 3) obstacles as identified by a survey of current early career members of the American College of Cardiology; 4) major reasons for the failure of physician-scientists to receive funding from National Institute of Health/National Heart Lung and Blood Institute career development grants; 5) potential solutions; and 6) a call to action with specific recommendations.
Interstitial Lung Disease, Lung Cancer, Lung Transplantation, Pulmonary Vascular Disorders, and Sleep-disordered Breathing in <i>AJRCCM</i> in 2004
Authors: T. Douglas Bradley, York E. Miller, Fernando J. Martinez, Derek C. Angus, William MacNee, Edward Abraham
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Denver Veterans Affairs Medical Center; Departments of Medicine and Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado; Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
Fasting Hyperglycemia Predicts the Magnitude of Postprandial Hyperglycemia
Authors: Mary F. Carroll, Ahmad Izard, Katrina Riboni, Mark R. Burge, David S. Schade
Journal: Diabetes Care (2002)

Postprandial blood glucose is a strong predictor of HbA1c levels and cardiovascular mortality (1–3). The treatment of postprandial hyperglycemia has become prominent with the recent availability of oral hypoglycemic agents that specifically target the postmeal glucose rise. The aim of this study was to examine the relationship between the fasting blood glucose level and the magnitude of the postprandial glucose rise in type 2 diabetes. Specifically, if the fasting blood glucose level is a determinant of the postprandial glucose excursion, then correction of fasting hyperglycemia should precede attempts at limiting postprandial hyperglycemia.

All results are expressed as means ± SD. A total of 21 subjects (11 men and 10 women) with non-insulin-requiring type 2 diabetes and average glycemic control (HbA1c 7.3 ± 1.4%) were recruited. The subjects were aged 59.4 ± 11.1 years, were moderately obese (BMI 31.3 ± 5.5 kg/m2), and had been diagnosed with diabetes for 8.7 ± 8.8 years. Two of the patients were treated with diet and exercise alone, and the remaining 19 were taking one or two oral hypoglycemic agents for diabetes control ( n = 13 for sulfonylureas, n = 6 for …
A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells
Authors: Aya Shibamiya, Karin Hersemeyer, Thomas Schmidt Wöll, Daniel Sedding, Jan-Marcus Daniel, Stefan Bauer, Takatoshi Koyama, Klaus T. Preissner, Sandip M. Kanse
Journal: Blood (2008)
MENTAL TESTS FOR MOTORISTS
Authors: William C. Ewing
Journal: JAMA (1923)

To the Editor:  —In the editorial comment (The Journal, September 8, p. 835) in which is suggested the devising of standards for drivers of motor vehicles, there occurs a suggestion that seems to me might well be amplified by those who are specializing on psychologic tests. The various works on this subject and particularly the articles in the Journal of Personnel Research show that while progress in reliable mental tests is slow, it is, nevertheless, continuous and practically useful in industry. Not only have special tests been devised which show the fitness of persons for particular occupations, but these tests are also being used in practice in the employment departments of a number of the most progressive employers of labor.  The use of special psychologic tests in a few of the most modernized of our civil service departments indicates, as does your comment, the feasibility of extending the same principle
Abstract PL01: Screening mammography and overdiagnosis
Authors: HG Welch
Journal: Cancer Research (2013)

Abstract Cancer screening involves trade-offs. Screening offers the potential benefit of avoiding advanced cancer and subsequent cancer death. It also produces the harms of false alarms, overdiagnosis and unnecessary treatment. Because different individuals value these benefits and harms differently, there is no single calculation to answer the question of what to do. The trade-off of benefits and harms is present in screening mammography. The reduction in breast cancer mortality identified in the original randomized trials has likely been diminished by subsequent – and substantial – improvements in treatment. The rate of false positives can be high – particularly in the United States. Less familiar is the harm of overdiagnosis: the detection of early cancers that are not destined to ever cause clinicaldisease. Because women given the diagnosis of “cancer” are generally treated, overdiagnosis is rarely directly observed. Instead, inferences about overdiagnosis are based on indirect evidence: long-term follow-up of randomized trials and changes in stage-specific incidence over time. There is no single “right” number to describe the magnitude of either the benefits or harms of screening mammography and there is no single “right” value to assign to the various outcomes. Consequently, screening mammography is a choice – not a public health imperative. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr PL01.
Laboratory Contributions to the Tobacco-cancer Problem
Authors: E. L. Wynder
Journal: BMJ (1959)

The sum total of evidence linking smoking to cancer of the respiratory tract is based upon different types of evidence: presumptive, epidemiological, pathological, animal, and chemical.All of the evidence so far established demonstrates smoking to be a carcinogenic factr.TFis niiow ourtasikto bring, the problem posed 6y-this association to a successful solution.The present report represents an evaluation of the contributions that laboratory research is making in this field.The importance of laboratory work is not to prove that smoking is a cause of cancer in man.Such proof can only come from human epidemiological investiga- tion.Laboratory research can, however, contribute to, and give a logical explanation for, the human findings.Just as an animal experiment cannot disprove that a given factor causes cancer in man because of possible species differences, so, by itself, an experiment cannot prove a given agent to be carcinogenic to man.It is primarily as a corollary to the human findings that the animal experiment has its significance.The basic tasks of laboratory research, which are of a biological and chemical nature, are to identify the specific agents in a given product that produces cancer and to devise ways and means whereby such agents can be reduced or removed.In so doing, we can only assume that the agents responsible for the activity in animals are also responsible for the human activity.In view of the many similarities established for tumour growth in animals and man, such an assumption, though it cannot be
Systematic review finds no benefits to population screening for dementia
Authors: N. Hawkes
Journal: BMJ (2013)

Screening the population for dementia offers no clinical benefits, a systematic review of the evidence has shown, while potential harms such as the risk of depression, anxiety, stigma or loss of independence remain unexamined in any study the researchers could find.

Carol Brayne, of the Cambridge Institute for Public Health, and the study’s lead author said, “Policy makers should be very cautious about adopting population screening for dementia without any evidence of …
Rsk2 controls synovial fibroblast hyperplasia and the course of arthritis
Authors: Anja Derer, Christina Böhm, Bettina Grötsch, Joachim R Grün, Andreas Grützkau, Michael Stock, Sybille Böhm, Udo Gaipl, Georg Schett, Axel J Hueber, Jean-Pierre David, Bettina Sehnert
Journal: Annals of the Rheumatic Diseases (2014)

Arthritis is a chronic inflammatory disease characterised by immune cell infiltration and mesenchymal cell expansion in the joints. Although the role of immune cells in arthritis is well characterised, the development of mesenchymal cell hyperplasia needs to be better defined. Here, we analysed the role of the ribosomal S6 kinase Rsk2, which we found to be highly activated in joints of patients with arthritis, in the development of mesenchymal cell hyperplasia. We genetically inactivated Rsk2 in the tumour necrosis factor (TNF)-α transgenic (TNFtg) mice, an animal model for human inflammatory arthritis. Clinical and histological signs of arthritis as well as molecular markers of inflammation and joint destruction were quantified. Fibroblast-like synoviocytes (FLS) were characterised in vitro and the effect of Rsk2 deletion on the pattern of gene expression was determined. Rsk2 deficiency in TNFtg mice results in earlier and exacerbated inflammation as well as increased bone and cartilage destruction. The production of inflammatory cytokines, matrix metalloproteinases and osteoclastogenic molecules was significantly increased in vivo upon Rsk2 inactivation. Bone marrow deficient in Rsk2 could not transfer this phenotype, indicating that Rsk2 expression in mesenchymal cells controls the course of arthritis. Indeed, Rsk2 deficiency was associated with a more activated phenotype and higher proliferative capacity of FLS, thereby increasing cytokines and production of matrix proteinases. Rsk2 emerges as a key regulator of mesenchymal cell numbers in the joint and thereby could be targeted to control the inflammatory and tissue-destructive feature of joints in arthritis.
Abstract 3742: Targeting the stem cell factor HMGA2 to improve outcomes in glioblastoma.
Authors: Harpreet Kaur, Marianne Hutt, Xing-gang Mao, Charles G. Eberhart, Eric H. Raabe
Journal: Cancer Research (2013)

Abstract Glioblastoma Multiforme (GBM) causes the majority of brain tumor-related deaths in the United States. The high invasiveness of GBM prevents complete surgical resection, allowing tumor recurrence. The lack of curative treatment highlights a dire need to develop specific targeted therapeutics. Identifying and targeting novel molecular markers in glioma stem-like cells (GSCs), one of the major causes of tumor invasion and recurrence, could lead to development of better therapies. HMGA2, a non-histone transcriptional modulator, is a regulator of normal and cancer stem cells. The significance of HMGA2 as a potential therapeutic target in GBM has not been investigated. To elucidate the role of HMGA2 in GBM, we have used a combination of in vitro and in vivo techniques in the present study. We found high expression of HMGA2 mRNA and protein in a subset of primary brain tumor samples from GBM patients, GBM cell lines and GBM stem-cell lines using quantitative real-time PCR and immunoblotting. Short hairpin RNA (shRNA)-mediated reduction of HMGA2 significantly inhibited invasion of GBM cell lines (U-87 MG and LN-229, 32 and 70% inhibition, respectively, with HMGA2 shRNA vs. control shRNA, P&amp;lt;0.001) and GBM stem cell lines (040821, 62% inhibition with HMGA2 shRNA vs. control shRNA, P&amp;lt;0.001) through Matrigel in vitro by transwell invasion assays. Conversely, overexpression of HMGA2 in GBM stem cell lines increased invasion (130% increase with HMGA2 overexpression vs. control vector, P&amp;lt;0.0001) through Matrigel in vitro as demonstrated by transwell invasion assays. In addition, overexpression of HMGA2 increased clonogenicity of GBM stem cell lines in vitro in soft agar and methylcellulose clonogenic assays (40% increase with HMGA2 overexpression vs. control vector, P&amp;lt;0.0001). Importantly, Kaplan-Meier analysis showed increased survival of mice injected with GBM stem cell lines transduced with HMGA2 shRNA compared to control shRNA (P&amp;lt;0.05) in an in vivo, orthotopic, intracranial mouse xenograft model. Together, our results suggest the importance of HMGA2 in promoting tumorigenicity of GBM by increasing invasiveness and a stem-like state, thereby suggesting that HMGA2 is a potential therapeutic target in GBM. Future studies are aimed at elucidating the molecular mechanism by which HMGA2 regulates invasion and stemness in GBM. Citation Format: Harpreet Kaur, Marianne Hutt, Xing-gang Mao, Charles G. Eberhart, Eric H. Raabe. Targeting the stem cell factor HMGA2 to improve outcomes in glioblastoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3742. doi:10.1158/1538-7445.AM2013-3742
Medical aspects of scuba diving Standards for diabetic divers are workable
Authors: C J Edge, P Wilmshurst
Journal: BMJ (1994)

reported by Super and colleagues, one had completed their family and another five did not request parental diagnosis.This contrasts with the 12 heterozygous couples detected through our antenatal screening programmes,23 all of whom have requested prenatal diagnosis.It is impossible to measure the theoretical effectiveness of cascade testing by simple extrapolation.It is necessary to create models with family size distributions and alternative testing strategies.Our projections, using such modelling, suggest that less than 25% of heterozygous couples be detected by cascading to the second cousin level.4In contrast, we have already shown that over 50% of heterozygous couples can be detected by either of the two major forms of antenatal screening.
Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/− mice
Authors: Hongbo Wang, Frederick Bauzon, Peng Ji, Xiaoliang Xu, Daqian Sun, Joseph Locker, Rani S Sellers, Keiko Nakayama, Keiich I Nakayama, David Cobrinik, Liang Zhu
Journal: Nature Genetics (2009)
How To Do It
Authors: Harriet S. Meyer
Journal: JAMA (1986)

An unusual assortment of nearly 50 topics are covered in this manual. As the editor suggests in the preface, it should be quite useful for the physician taking a first post-training position. Among topics one rarely or never would find treated anywhere else are "Chair a Committee," "Give a Press Conference," "Become a Medical Journalist or Editor," "Appear on Television," "Prepare a Lecture," "Use an Overhead Projector," "Referee a Paper," "Deal With a Publisher," and "Beautify Your Old Hospital." Many chapters are only a few pages long, but the opening chapter, "Organise an International Medical Meeting," is more than 30 pages long and deals with a range of topics from "The Committee" to "The Dinner." Some chapters, such as "Prepare an MD Thesis," are pertinent to a British audience, but even one such as "Giving Evidence"—a topic that is covered at greater length in many other books and symposia—still has
Lithium and Generic Nonequivalence
Authors: GARY E. PAKES
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 June 1979Lithium and Generic NonequivalenceGARY E. PAKES, PHARM, D.GARY E. PAKES, PHARM, D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-994_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Lithium carbonate is now marketed in 300-mg dosage forms by five different manufacturers. A liquid form of lithium, as the citrate salt, was also introduced in 1978, with each teaspoonful providing the lithium equivalent of a 300-mg tablet or capsule. Although the individual manufacturers have provided data showing bioequivalence of their marketed lithium dosage forms (1, 2), little has been published investigating comparative bioavailability of different brands.At this institution, two cases have concerned us in this regard. In one case, a manic-depressive patient who had received 300 mg of a popular brand (Eskalith®) four times daily...References1. : Lithonate® and Lithotabs®, Bioavailability Report. Baudette, Minnesota, Rowell Laboratories, Inc., 1977, pp. 1-4 Google Scholar2. CALDWELLWESTLAKECONNORFLANAGAN HWST: A pharmacokinetic analysis of lithium carbonate absorption from several formulations in man. J Clin Pharmacol 11:349-356, 1971 Google Scholar3. SUGITASTOKESFRAZERGROFMENDELSGOLDSTEINNIEBERGALL EJAPJFP: Lithium carbonate absorption in humans. J Clin Pharmacol 13:264-270, 1973 MedlineGoogle Scholar4. VARLEY A: The generic inequivalence of drugs. JAMA 206:1745, 1968 CrossrefMedlineGoogle Scholar5. SCHNELLER G: Hazard of therapeutic nonequivalency of drug products. J Am Pharm Assoc NS 9:455-457, 1969 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brotman Memorial Hospital Culver City, CA 90230 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySwitching from Brand-Name to Generic Psychotropic Medications: A Literature Review 1 June 1979Volume 90, Issue 6Page: 994-994KeywordsCarbonatesSalts Issue Published: 1 June 1979 PDF DownloadLoading ...