Hyperoxaluria and Renal Insufficiency Due to Ascorbic Acid Administration During Total Parenteral Nutrition
Authors: Richard D. Swartz, John R. Wesley, Michael G. Somermeyer, Kai Lau
Journal: Annals of Internal Medicine (1984)

Brief Reports1 April 1984Hyperoxaluria and Renal Insufficiency Due to Ascorbic Acid Administration During Total Parenteral NutritionRICHARD D. SWARTZ, M.D., JOHN R. WESLEY, M.D., MICHAEL G. SOMERMEYER, M.D., KAI LAU, M.D.RICHARD D. SWARTZ, M.D., JOHN R. WESLEY, M.D., MICHAEL G. SOMERMEYER, M.D., KAI LAU, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-530 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyperoxaluria associated with nephrolithiasis and with renal insufficiency may result from increased enteral oxalate absorption with intestinal disease (1, 2) or synthesis from increased oxalate precursor. Ascorbic acid is one such precursor, reported to increase urinary excretion of oxalate at high oral doses in humans (3-6). We report a patient with extensive bowel resection who developed hyperoxaluria and renal insufficiency that was causally related to parenteral ascorbic acid during total parenteral nutrition and abated when ascorbic acid was discontinued. The data define a dose-response relation between administered ascorbic acid and excreted oxalate.A 22-year-old white woman who weighed 45 kg...References1. SMITHFROMMHOFMANN LHA. Acquired hyperoxaluria, nephrolithiasis and intestinal disease: description of a new syndrome. N Engl J Med. 1972;286:1371-4. CrossrefMedlineGoogle Scholar2. DRENICKSTANLEYBORDER ETW. Renal damage with intestinal bypass. Ann Intern Med. 1978;89:594-9. LinkGoogle Scholar3. ATKINSDEANGRIFFINWATTS GBWR. Quantitative aspects of ascorbic acid metabolism in man. J Biol Chem. 1964;239:297580. CrossrefGoogle Scholar4. BRIGGSGARCIA-WEBBDAVIES MPP. Urinary oxalate and vitamin C supplements [Letter]. Lancet. 1973;2:201. CrossrefMedlineGoogle Scholar5. 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Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD D. SWARTZ, M.D.; JOHN R. WESLEY, M.D.; MICHAEL G. SOMERMEYER, M.D.; KAI LAU, M.D.Affiliations: University of Michigan Medical Center Ann Arbor, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChildren with Intestinal Failure Maintain Their Renal Function on Long-Term Parenteral NutritionVitamin C-Induced Oxalate Nephropathy in a Septic PatientIntestinal failure as a significant risk factor for renal impairment in childrenSecondary hyperoxaluria: a risk factor for kidney stone formation and renal failure in native kidneys and renal graftsRenal consequences of parenteral nutritionToxicities Associated with Parenteral NutritionOxalic acid excretion after intravenous ascorbic acid administrationFatal Vitamin C-associated Acute Renal FailureVitamin C-induced hyperoxaluria causing reversible tubulointerstitial nephritis and chronic renal failure: a case reportEarly postoperative substitution procedure of the antioxidant ascorbic acidRapidly progressive irreversible renal failure in patients with pancreatic insufficiencyOntogenic Variations of Ascorbic Acid and Phenethyl Isothiocyanate Concentrations in Watercress ( Nasturtium officinale R.Br.) 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TSAO, PH.D 1 April 1984Volume 100, Issue 4Page: 530-531KeywordsColectomyExcretionNephrologyRenal diseasesResearch laboratoriesTotal parenteral nutrition ePublished: 1 December 2008 Issue Published: 1 April 1984 PDF downloadLoading ...