tbuckley/cabot-search huggingface dataset:
Subclinical coeliac disease and infertility.
Authors: C Wilson, O E Eade, M Elstein, R Wright
Journal: BMJ (1976)

athetosis' and may occur in psychological illnesses, especially hysteria, and with drugs such as phenothiazines and levodopa.5This report adds amodiaquine to the list.Involuntary movements after taking phenothiazines have been attributed to toxic overdose or to individual idiosyncrasy.The doses of amodiaquine in our cases were large but not large enough to be toxic.The patients' reactions were therefore probably idiosyncratic.The rarity of such cases supports this view.
TCT-117 Peri-procedural and Follow up Outcomes after Endovascular Abdominal Aortic Aneurysm Repair by Interventional Cardiologists
Authors: Abhijeet Basoor, Kirit Patel, Abdul Halabi, Nishit Choksi, Thanh Phan, Michele DeGregorio
Journal: Journal of the American College of Cardiology (2012)
Psychological and Physiopathological Study on Coronary Patients
Authors: C. Maggini, M. Guazzelli, P. Castrogiovanni, M. Mauri, G.F. de Lisio, S. Chierchia, G.B. Cassano
Journal: Psychotherapy and Psychosomatics (1976)

In this paper the AA have tried to define the relationship between psychopathological characteristics or symptoms and angina attacks in coronary patients. The research plan was agreed upon and carried out as a collaborative program between psychiatrists and internists with the goal of reaching a more comprehensive approach to the psychosomatic patient. In 20 patients suffering from nocturnal angina attacks the polygraphic sleep recording was performed; 10 of them received psychodiagnostic examination (MMPI). In 8 cases during sleep recordings hemodynamic monitoring was also performed. The MMPI data were compared with 82 other individuals who had myocardial infarction (56 ss) and diurnal angina (26 ss) and 34 control subjects without cardiac disease. The results show that the sleep patterns were strongly affected and the most relevant alterations were recorded during the nights with ischemic episodes. No significant correlations were found between ischemic episodes and sleep stages. In no instance did the hemodynamic monitoring show an increase in the parameters related to myocardial oxygen consumption. The psychological data showed that the most severe symptomatology was observed in the nocturnal angina patients where the disease seems to be mostly related to a functional pathogenic mechanism.
Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1
Authors: Ai-Luen Wu, Ganesh Kolumam, Scott Stawicki, Yongmei Chen, Jun Li, Jose Zavala-Solorio, Khanhky Phamluong, Bo Feng, Li Li, Scot Marsters, Lance Kates, Nicholas van Bruggen, Maya Leabman, Anne Wong, David West, Howard Stern, Elizabeth Luis, Hok Seon Kim, Daniel Yansura, Andrew S. Peterson, Ellen Filvaroff, Yan Wu, Junichiro Sonoda
Journal: Science Translational Medicine (2011)

Antibody-mediated activation of fibroblast growth factor receptor 1 reverses the diabetic phenotype in mice, likely by affecting brown adipose tissues.
The Left Atrial Pressure Pulses in Experimental Mitral Valve Lesions
Authors: O. M. HARING, C. K. LIU, H. D. TRACE, A.A Luisada
Journal: Circulation Research (1956)

Comparative studies of left atrial electrokymograms, left atrial pressure tracings, and pulmonary wedge pressure tracings were made in dogs with experimental mitral insufficiency or stenosis. Typical patterns were found in pure insufficiency or stenosis. A remarkable coincidence was found between pressure tracings and electrokymograms of the left atrium.
John Magoveny King
Authors: R. Sill
Journal: BMJ (2010)

After house jobs in Greenock Royal Infirmary and Glasgow Western Infirmary, John Magoveny King (“Jack”) was called up to the Royal Army Medical Corps, serving first as a regimental medical officer to the 86th Field Regiment Royal Artillery. From 1943 to 1946 Jack served in Italy as a captain in the 140th Field Ambulance and later in the 44th Reconnaissance Regiment. Jack was shipped home in 1946 …
Evidence-Based Dermatology
Authors: Lawrence C. Parish
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth
Authors: Benno Kreuels, Christina Kreuzberg, Robin Kobbe, Matilda Ayim-Akonor, Peter Apiah-Thompson, Benedicta Thompson, Christa Ehmen, Samuel Adjei, Iris Langefeld, Ohene Adjei, Jürgen May
Journal: Blood (2010)
US abortion rates rise among poor women but fall overall
Authors: J. H. Tanne
Journal: BMJ (2011)

Abortion rates declined 8% in the United States from 2000 to 2008 except among poor women—shows a study by the Guttmacher Institute, which advocates for sexual and reproductive health worldwide and conducts research.

Among women whose family incomes were below 100% of the federal poverty level—about $22 350 (£13 600; €15 500) for a family of four—the abortion rate increased 18% from 44.4 abortions per 1000 women aged 15-44 in 2000, to 52.2 in 2008.

The study, published in Obstetrics and Gynecology , uses data from the Institute’s 2008 …
Professional Standards Review Organization and Care of the Elderly
Authors: Ian R. Lawson
Journal: JAMA (1974)

THE institution that I serve, The Hebrew Home, Hartford, Conn, has a responsibility mainly for disabled elderly patients, for whose varied needs we have attempted to provide a spectrum of institutional geriatric care. The Hebrew Home includes a professional assessment of need made in the patient's home, hospital rehabilitation care, long-term nursing care, and day-hospital care. This is all in response to a public expectancy, nourished a good deal by Title XVIII and XIX enactments that services will be provided for the elderly according to evident need and disability. Hence, should future fiscal-professional formulas fall seriously short of supporting that need, providers like our Home staff will be in the front line of embarassment, the more so because we have attempted the ideal in comprehensive care. In connection with Titles XVIII and XIX, we have seen already that later statutory and fiscal amendments may seriously limit the care of the
Type VII collagen is expressed but anchoring fibrils are defective in dystrophic epidermolysis bullosa inversa
Authors: LEENA BRUCKNER-TUDERMAN, KIRSTI-MARIA NIEMI, MATTI KERO, URS W. SCHNYDER, TIMO REUNALA
Journal: British Journal of Dermatology (1990)

A patient with dystrophic epidermolysis bullosa inversa was studied using electron microscopy and indirect immunofluorescence using antibodies to matrix macromolecules of the dermo-epidermal junction zone. There was splitting below the lamina densa with an apparently normal basement membrane, but a lack of intact anchoring fibrils and with a disarranged papillary connective tissue. Indirect immunofluorescence examination with antibodies to type VII collagen, the major structural protein of anchoring fibrils, showed a normal linear staining pattern. Synthesis of type VII collagen which is unable to form stable, resistant anchoring fibrils may be a distinct feature of this subtype of recessive dystrophic epidermolysis bullosa.
Hyaluronan Enhances Bone Marrow Cell Therapy for Myocardial Repair After Infarction
Authors: Chien-Hsi Chen, Shoei-Shen Wang, Erika IH Wei, Ting-Yu Chu, Patrick CH Hsieh
Journal: Molecular Therapy (2013)

Hyaluronan (HA) has been shown to play an important role during early heart development and promote angiogenesis under various physiological and pathological conditions. In recent years, stem cell therapy, which may reduce cardiomyocyte apoptosis, increase neovascularization, and prevent cardiac fibrosis, has emerged as a promising approach to treat myocardial infarction (MI). However, effective delivery of stem cells for cardiac therapy remains a major challenge. In this study, we tested whether transplanting a combination of HA and allogeneic bone marrow mononuclear cells (MNCs) promotes cell therapy efficacy and thus improves cardiac performance after MI in rats. We showed that HA provided a favorable microenvironment for cell adhesion, proliferation, and vascular differentiation in MNC culture. Following MI in rats, compared with the injection of HA alone or MNC alone, injection of both HA and MNCs significantly reduced inflammatory cell infiltration, cardiomyocyte apoptosis, and infarct size and also improved cell retention, angiogenesis, and arteriogenesis, and thus the overall cardiac performance. Ultimately, HA/MNC treatment improved vasculature engraftment of transplanted cells in the infarcted region. Together, our results indicate that combining the biocompatible material HA with bone marrow stem cells exerts a therapeutic effect on heart repair and may further provide potential treatment for ischemic diseases. Hyaluronan (HA) has been shown to play an important role during early heart development and promote angiogenesis under various physiological and pathological conditions. In recent years, stem cell therapy, which may reduce cardiomyocyte apoptosis, increase neovascularization, and prevent cardiac fibrosis, has emerged as a promising approach to treat myocardial infarction (MI). However, effective delivery of stem cells for cardiac therapy remains a major challenge. In this study, we tested whether transplanting a combination of HA and allogeneic bone marrow mononuclear cells (MNCs) promotes cell therapy efficacy and thus improves cardiac performance after MI in rats. We showed that HA provided a favorable microenvironment for cell adhesion, proliferation, and vascular differentiation in MNC culture. Following MI in rats, compared with the injection of HA alone or MNC alone, injection of both HA and MNCs significantly reduced inflammatory cell infiltration, cardiomyocyte apoptosis, and infarct size and also improved cell retention, angiogenesis, and arteriogenesis, and thus the overall cardiac performance. Ultimately, HA/MNC treatment improved vasculature engraftment of transplanted cells in the infarcted region. Together, our results indicate that combining the biocompatible material HA with bone marrow stem cells exerts a therapeutic effect on heart repair and may further provide potential treatment for ischemic diseases.
Tedizolid: A Novel Oxazolidinone with Potent Activity Against Multidrug-Resistant Gram-Positive Pathogens
Authors: George G. Zhanel, Riley Love, Heather Adam, Alyssa Golden, Sheryl Zelenitsky, Frank Schweizer, Bala Gorityala, Philippe R. S. Lagacé-Wiens, Ethan Rubinstein, Andrew Walkty, Alfred S. Gin, Matthew Gilmour, Daryl J. Hoban, Joseph P. Lynch, James A. Karlowsky
Journal: Drugs (2015)
NHS must start reconfiguring services if it is to meet savings challenge, says National Audit Office
Authors: G. Iacobucci
Journal: BMJ (2012)

The NHS in England has made a positive start towards meeting the government’s target of £20bn (€25bn; $32bn) in efficiency savings by 2014-15, but progress may stall unless attention is urgently shifted to transformation of services, auditors have warned.

The National Audit Office said that the NHS had delivered efficiency savings of £5.8bn in 2011-12, against a target of £5.9bn, by concentrating on the “easiest savings” borne from reducing national tariff prices by 1.5% and freezing staff pay for two years.

But its new report said that the NHS would struggle to repeat these savings for the remainder of the government’s quality, innovation, productivity, and prevention (QIPP) drive unless it turned its attention to service reconfiguration.1

The efficiency drive, dubbed the “Nicholson challenge” after its architect, David Nicholson, the NHS’s chief executive,2 requires the health service …
Cancer of the Gastrointestinal Tract
Authors: Philip Rubin
Journal: JAMA (1974)

DESPITE the gains in therapeutic techniques, there has been no major improvement in the long-term survival of patients with stomach cancer. The detection of gastric cancer through clinical and roentgenographic findings pronounces a death sentence on the patient; merely the overt recognition of this cancer is a sign of advancement. Most clinical reports read the same<sup>1,2</sup>: for every 100 patients, 60 to 80 undergo exploratory surgery; resections are performed in 30 to 40, and 5% to 15% survive, depending on the number of patients in whom disease is limited to the stomach. Marshall<sup>3</sup>has shown that the five-year survival decreases from 34.8% to 7.2% when lymph nodal invasion occurs. This is the most critical factor in determining prognosis; lymph node invasion is present in two thirds of patients who undergo resection.<sup>3</sup> There is little correlation between the aggressiveness of surgical resection and the ultimate outcome for the patient. The
HOME TREATMENT OF PSYCHIATRIC PATIENTS
Authors: T. T. FRIEDMAN, PHYLLIS ROLFE, STEWART E. PERRY
Journal: American Journal of Psychiatry (1960)

The present report refers to 60 cases seen in the first 15 months of a small Home Treatment Service. The doctor, accompanied by a social worker, functions as a general practitioner-psychiatrist, working primarily in the home and collaborating directly with community agencies. Inaccessible patients can be reached at home for either brief or long-term therapy, and families may be directly included in the treatment process. Appropriate alternatives to hospitalization can be worked out and numerous agencies helped to coordinate their function in helping a family. A Home Treatment Service also provides an opportunity for mental health education to families, doctors and social agencies around concrete situations and on a personal basis.
Chemokine Receptor CCR9 Contributes to the Localization of Plasma Cells to the Small Intestine
Authors: Oliver Pabst, Lars Ohl, Meike Wendland, Marc-André Wurbel, Elisabeth Kremmer, Bernard Malissen, Reinhold Förster
Journal: The Journal of Experimental Medicine (2004)

Humoral immunity in the gut-associated lymphoid tissue is characterized by the production of immunoglobulin A (IgA) by antibody-secreting plasma cells (PCs) in the lamina propria. The chemokine CCL25 is expressed by intestinal epithelial cells and is capable of inducing chemotaxis of IgA+ PCs in vitro. Using a newly generated monoclonal antibody against murine CCR9, we show that IgA+ PCs express high levels of CCR9 in the mesenteric lymph node (MLN) and Peyer's patches (PPs), but down-regulate CCR9 once they are located in the small intestine. In CCR9-deficient mice, IgA+ PCs are substantially reduced in number in the lamina propria of the small intestine. In adoptive transfer experiments, CCR9-deficient IgA+ PCs show reduced migration into the small intestine compared with wild-type controls. Furthermore, CCR9 mutants fail to mount a regular IgA response to an orally administered antigen, although the architecture and cell type composition of PPs and MLN are unaffected and are functional for the generation of IgA PCs. These findings provide profound in vivo evidence that CCL25/CCR9 guides PCs into the small intestine.
Congenital Myasthenic Syndrome Caused by Decreased Agonist Binding Affinity Due to a Mutation in the Acetylcholine Receptor ε Subunit
Authors: Kinji Ohno, Hai-Long Wang, Margherita Milone, Nina Bren, Joan M Brengman, Satoshi Nakano, Polly Quiram, Jerry N Pruitt, Steven M Sine, Andrew G Engel
Journal: Neuron (1996)
Staff problem in old people's homes
Authors: P. H Millard, R Bailey
Journal: BMJ (1981)

dextrous patients being combined in the "non- right-handed" group.The results showed a marginally significant tendency for non-right- handedness to be overrepresented among schizo- phrenics (Z2 corrected for continuity-=2-99; p <O05 (one tailed)).We conclude that to claim an association between psychosis and left-handedness is too general.Even the association which was here found between one specific psychotic condition and sinistrality was rather weak.We do not wish to question the assertion that in some subgroups of schizophrenia there is evidence of minimal neurological dysfunction, of which left-handedness may be a part; but our results remind us that there remains the need to explain the aetiology in the larger proportion of psychotic patients who show no evidence of such neurological involvement.The results of our survey suggest that sinistrality is maybe not as sinister as you say.
Hypertension—Primary and Secondary
Authors: JOSEPH J. KAUFMAN
Journal: Annals of Internal Medicine (1971)

High blood pressure has received abundant clinical and laboratory attention in recent years. Some 6% of whites and 20% of negroes in the United States are affected by arterial hypertension. The number of cases secondary to renal and adrenal lesions has increased, with a corresponding reduction in the number of patients relegated to the category of essential hypertension. The chief causes of secondary hypertension are renal artery stenosis, primary aldosteronism, and, more recently, excess adrenal secretion of 18-hydroxydeoxycorticosterone. Those patients in the latter category are an exciting group, potentially treatable with dexamethasone. The radiological study of patients with hypertension is highly important, with the intravenous urogram remaining the best screening test. Arteriography and adrenal venography are being used with greater frequency. Drug therapy of hypertension has reached a new stage of effectiveness and specificity, and many patients can be successfully managed medically. The chief indications for surgical intervention are renal artery stenosis in good-risk individuals with definite criteria of renal ischemia, pheochromocytoma, and primary aldosteronism. Many of the reconstructive operations considered speculative only 8 years ago are now proving their long-range usefulness and durability.
Severe disability: 2--Residential care and living in the community.
Authors: D Gloag
Journal: BMJ (1985)

The climate of opinion is changing. The inevitability of some such scheme is increasingly being accepted. We believe that discussions on financing a scheme should be opened between the principally interested parties with the aim of producing a scheme that is so obviously workable and in the public interest that the government will not wish to, indeed cannot, stand aside.
Has Glenberg forgotten his nurse?
Authors: Arthur M. Jacobs, Johannes C. Ziegler
Journal: Behavioral and Brain Sciences (1997)

Glenberg's conception of “meaning from and for action” is too narrow. For example, it provides no satisfactory account of the “logic of Elfland,” a metaphor used by Chesterton to refer to meaning acquired by being told something. All that we call spirit and art and ecstasy only means that for one awful instant we remember that we forget. G. K. Chesterton (in Gardner 1994, p. 101)
NOTE ON THE AETIOLOGY OF LEPROSY
Authors: WILLIAM TURNER
Journal: British Journal of Dermatology (1911)

Journal Article NOTE ON THE ÆTIOLOGY OF LEPROSY Get access WILLIAM TURNER, M.A., M.D WILLIAM TURNER, M.A., M.D Gibraltar Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 23, Issue 9, 1 September 1911, Pages 291–294, https://doi.org/10.1111/j.1365-2133.1911.tb16684.x Published: 01 September 1911
The Diagnosis of Growth Hormone Deficiency in Children and Adults
Authors: Stephen Michael Shalet, Andrew Toogood, Asad Rahim, Bernadette M. D. Brennan
Journal: Endocrine Reviews (1998)

A. Clinical aspects B. Radiology C. GH provocative tests D. Physiological assessment of GH secretion E. IGFs F. IGFBPs G. Newer strategies for assessment
Rapid sequence variation of the hypervariable region of hepatitis C virus during the course of chronic infection
Authors: Masayuki Kurosaki, Nobuyuki Enomoto, Fumiaki Marumo, Chifumi Sato
Journal: Hepatology (1993)

To evaluate the clinical significance of sequence variations in the hypervariable region of hepatitis C virus during the course of chronic infection, we performed pairwise comparison of the predominant nucleotide sequences. Hepatitis C virus RNA was extracted from two plasma samples obtained from 12 chronically infected Japanese patients over approximately 1 yr. Complementary DNA containing the hypervariable region was amplified by means of reverse transcription-polymerase chain reaction and was directly sequenced for determination of predominant sequences. In all 12 individuals, the predominant sequence of the hypervariable region at the second time point differed from that at the first time point, and significant sequence variation was observed during this short period. A high proportion of these nucleotide substitutions (90%) resulted in changes of predicted amino acid sequences, indirect evidence of in vivo positive selection for these variants. There appeared to be an important difference in the rate of nucleotide sequence variation of the hypervariable region between four patients with flare-ups of their ALT levels (1.54 to 2.24 x 10(-1)/genome site/yr) and eight patients with quiescent courses (0.13 to 1.21 x 10(-1)/genome site/yr). These results demonstrate that rapid sequence variations of the hypervariable region of predominant virus population take place during the natural course of chronic hepatitis C virus infection. These sequence variations seem to occur as an adaptive response of hepatitis C virus to evade host immunity and may play a major role in the establishment of persistent infection and in the occasional flare-up of hepatitis.