Severe Symptomatic Hyperkalemia in an Adrenalectomized Woman Due to Enhanced Mineralocorticoid Requirement
Authors: WILLIAM H. DAUGHADAY
Journal: Annals of Internal Medicine (1967)

Case Studies1 June 1967Severe Symptomatic Hyperkalemia in an Adrenalectomized Woman Due to Enhanced Mineralocorticoid RequirementWILLIAM H. DAUGHADAY, M.D., DAVID RENDLEMAN, M.D.WILLIAM H. DAUGHADAY, M.D.Search for more papers by this author, DAVID RENDLEMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-6-1197 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development of hyperkalemic neuromyopathy in untreated Addison's disease is unusual. The common picture of addisonian crisis is dominated by the signs and symptoms of hypovolemia and circulatory collapse. Moderate hyperkalemia occurs, but neuromuscular complaints attributable to the hyperkalemia can rarely be detected. With cortisone and mineralocorticoid treatment correction of the electrolyte disturbance is prompt. With the addition of potent mineralocorticoids such as fluorohydrocortisone (50 to 100 μg/day) to cortisone replacement (25 to 37.5 mg/day), serious disturbances of electrolyte levels in the plasma are rarely encountered, even when patients enter the hospital in acute collapse secondary to an intercurrent infection....References1. BULLCARTERLOWE GMABKG: Hyperpotassaemic paralysis. Lancet 2: 60, 1953. CrossrefGoogle Scholar2. MARKSFEIT LJE: Flaccid quadriplegia, hyperkalemia and Addison's disease. Arch. Intern. Med. (Chicago) 91: 56, 1953. CrossrefGoogle Scholar3. RICHARDSONSIBLEY GOJD: Flaccid quadriplegia associated with hyperpotassaemia. Canad. Med. Ass. J. 69: 504, 1953. MedlineGoogle Scholar4. MOLLARETGOULOWTOURNILHAC PMM: Contribution à l'etude des paralysies avec hyperkaliemie. I. Role de l'insuffisance corticosurrenalianne. Rev. Neurol. (Paris) 98: 341, 1958. MedlineGoogle Scholar5. POLLENWILLIAMS RHRH: Hyperkalemic neuromyopathy in Addison's disease. New Eng. J. 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Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM H. DAUGHADAY, M.D.; DAVID RENDLEMAN, M.D.Affiliations: St. Louis, MissouriFrom the Metabolism Division, Washington University School of Medicine, St. Louis, Mo.This study was supported by grant FR-36, Division of Research Facilities and Resources, General Clinical Research Centers Branch, and by training grant AM 5027, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to William H. Daughaday, M.D., Department of Medicine, Washington University School of Medicine, 4550 Scott Ave., St. Louis, Mo. 63110. 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DUGUID, M.B., CH.B., M.C.PATH.Muscle Wasting Disease of Endocrine Origin 1 June 1967Volume 66, Issue 6Page: 1197-1203KeywordsArthritisBlood plasmaLesionsMetabolic disordersMineralocorticoidsPyelonephritisResearch facilitiesSigns and symptoms ePublished: 1 December 2008 Issue Published: 1 June 1967 PDF downloadLoading ...