tbuckley/cabot-search huggingface dataset:
Intravital video-capillaroscopy for the study of the microcirculation in psoriasis
Authors: R.H. BULL, D.O. BATES, P.S. MORTIMER
Journal: British Journal of Dermatology (1992)

Intravital capillaroscopy using a video-microscopy system permits real-time imaging of the skin microvasculature with retrospective analysis of capillary dynamics. The addition of fluorescein angiography improves contrast and detects aspects of blood vessel behaviour, such as perfusion homogeneity and transcapillary solute diffusion, not detectable under native conditions. This study was performed to evaluate whether the method can be applied to the investigation of a skin disease and in particular the understanding of the role of the blood vessel in the pathogenesis of psoriasis. Results demonstrated clear differences between normal and psoriatic skin. More capillaries were red-cell perfused in both plaque and uninvolved skin compared to normal skin (P less than 0.001) and 0.01 less than P less than 0.02, respectively). The capillaries in psoriatic plaque skin were much larger than those in normal skin (P less than 0.001). The density of capillaries was not increased in plaque or uninvolved psoriatic skin, indicating expansion of existing vessels and not new vessel formation. The area of fluorescence seen around each capillary at 60 s was greater in plaque (P less than 0.001) and in uninvolved psoriatic skin (P less than 0.001) than in normal skin, indicating greater vessel transcapillary diffusion. This study confirms the value of video-microscopy as a non-invasive technique for the examination of the cutaneous microcirculation in vivo.
Medical notes--the patient's contribution?
Authors: V. Lobban
Journal: BMJ (1995)

Over the past five years I have been an outpatient at three hospitals, have seen five consultants, and had countless appointments, all of which relate to the same illness. Each time I see a different doctor I have to relate the history of the illness, investigations, and treatment. The first time that I saw a different consultant I was unprepared. I found …
SOME EFFECTS OF HOSPITALIZATION ON THE CLINICAL STATUS OF PATIENTS
Authors: John W. Higgins
Journal: JAMA (1953)

The fact that a patient has to go to a hospital is usually interpreted as meaning that he will be in a place of refuge and security, free of the usual stress and strain of ordinary living, and therefore relaxed and at ease. This view of the hospital as an asylum or a refuge may be especially adhered to for persons who seem prone to have difficulties with other persons in their environment. The implication is that the usual discords and incompatibilities in everyday existence with other persons have been rendered unimportant by hospitalization, or are in temporary abeyance. In this paper, we hope to demonstrate that such a view of the hospitalized patient is incomplete, and in fact may be seriously inaccurate. The hospital patient lives in close contact with a number of other persons, the other patients and the professional and nonprofessional staff of the hospital. Such interpersonal
Message From China
Authors: Gerson Jacobs
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Robert Moser's editorial on the Chinese people's love of their government (230:1566, 1974) may be true; I am certainly not in a position to know. But it does lack a knowledge of the history of the intellectual's experience with all other forms of Communism. Communist states are totalitarian states, in the sense used by Hannah Arendt, and none of us can know what the people of a Communist state really think. I wonder who Robert Moser's Chinese Solzhenitsyn will be.
P221Venous thromboembolism: secondary prevention with dabigatran vs. acenocumarol in patients with paraneoplastic deep vein thrombosis. Results from a small prospective study in Romania
Authors: L Mazilu, I R Parepa, A I Suceveanu, A Suceveanu, R Baz, D Catrinoiu
Journal: Cardiovascular Research (2014)

Background: Secondary prevention of thromboembolic disease in cancer patients with oral anticoagulants is a challenging issue, due to the particular liver biology in this high-risk category of subjects. Aim: To compare novel oral anticoagulant dabigatran vs acenocumarol administered in patients with malignant disease and deep vein thrombosis. Method. We randomized 46 patients with paraneoplastic deep vein thrombosis in two groups, matched by age, sex, cancer type and Khorana score in 2 groups: first group (n=23) assigned to bid fixed-dose dabigatran (according to individual creatinine clearance), and second group (n= 23) assigned to qd adjusted-dose acenocumarol (according to individual INR determined monthly). Patients were followed-up 6 months. Results: 6 patients from the dabigatran group (13.95%) experienced an adverse outcome (major bleeding or recurrent thrombosis), vs. 12 patients (52.817%) from acenocumarol group, showing a significant difference (P=0.0349; 95%CI=0.2266-1.103). No patient developed pulmonary thromboembolism.There was one death due to major bleeding in the acenocumarol group vs. none in dabigatran group. No difference in the progression of underlying cancer was noticed between the two studied groups (4 deaths in dabigatran group vs 5 deaths in acenocumarol group, OR= 0.7579; 95% CI= 0.1752-3.279; P=0.3551). Patients in the dabigatran group reported a better QOL due to the fact that there was no need for monthly blood tests as in acenocumarol group. Conclusion: In our study dabigatran was associated with a smaller rate of complications and may be safer in cancer patients with venous thromboembolism. Larger studies are needed, but difficult to be performed in this specific class of patients.
Drug Addiction in Youth
Authors: George Mora
Journal: JAMA (1965)

The topic of drug addiction in youth has thus far received relatively little thorough research. The topic sporadically may arouse a community when episodes of violence or delinquency related to drug addiction become prominent. When the emotional climate subsides, the problem of drug addiction is again pushed aside to the fringes of society where only a few dedicated men carry on difficult research and treatment programs. The fact that most of the young drug addicts belong to the lowest levels of society and that they are far from being cooperative further complicates the aim of the investigators.  The papers gathered in this book attempt to cover a variety of areas connected more or less directly with drug addiction in youth. They range from the discussion of the physiology and pharmacology of drug addiction and of drug withdrawal to the description of the psychology, therapeutic methods, and rehabilitation program of the
Multiple regions within 8q24 independently affect risk for prostate cancer
Authors: Christopher A Haiman, Nick Patterson, Matthew L Freedman, Simon R Myers, Malcolm C Pike, Alicja Waliszewska, Julie Neubauer, Arti Tandon, Christine Schirmer, Gavin J McDonald, Steven C Greenway, Daniel O Stram, Loic Le Marchand, Laurence N Kolonel, Melissa Frasco, David Wong, Loreall C Pooler, Kristin Ardlie, Ingrid Oakley-Girvan, Alice S Whittemore, Kathleen A Cooney, Esther M John, Sue A Ingles, David Altshuler, Brian E Henderson, David Reich
Journal: Nature Genetics (2007)
Pathologic changes following chronic exposures to halothane: a review.
Authors: L W Chang
Journal: Environmental Health Perspectives (1977)

The toxic effects of halothane on the liver, kidney, and brain are reviewed. Increasing evidence has indicated that hepatic degeneration can be induced in several animal speices after exposure to halothane. Recent electron microscopic investigations have also revealed cytological degeneration of the liver cells after chronic exposure to subclinical levels of halothane. Degeneration of the kidney and the nervous system after halothane exposure have also been reported. The pathological effects of halothane on the neonatal (developing) liver, kidney, and brain are also demonstrated by electron microscopy. Although the full significance of these observations on experimental animals in relationship to human exposure is still not known, the indication of the toxic potential of halothane on the biological system is strong and deserves further investigation.
Blood glucose awareness training and epinephrine responses to hypoglycemia during intensive treatment in type 1 diabetes.
Authors: B T Kinsley, K Weinger, M Bajaj, C J Levy, D C Simonson, M Quigley, D J Cox, A M Jacobson
Journal: Diabetes Care (1999)

OBJECTIVE: To determine the effect of blood glucose awareness training (BGAT) on epinephrine and symptom responses to hypoglycemia in patients with type 1 diabetes enrolled in an intensive diabetes treatment (IDT) program. RESEARCH DESIGN AND METHODS: A total of 47 subjects with uncomplicated diabetes (duration 9 +/- 3 years: HbA1c 9.0 +/- 1.2%; reference range 4-6%) enrolled in a 4-month outpatient IDT program were randomized to classes in BGAT (n = 25) (BGAT group) or cholesterol awareness (n = 22) (control group). Subjects underwent stepped hypoglycemic clamp studies before and at completion of IDT. Plasma glucose was lowered from 6.7 mmol/l (baseline) to 4.4, 3.9, 3.3, 2.8, and 2.2 mmol/l over 190 min. Symptoms, counterregulatory hormones, and ability of the subject to estimate their glucose level were assessed at each plateau. At home, subjects used a handheld computer to first estimate and then measure and record blood glucose levels for 70 trials over a 4-week period immediately before IDT and again immediately following the educational intervention. RESULTS: HbA1c decreased in both BGAT group (9.1 +/- 1.4 to 7.9 +/- 1.1%; P &amp;lt; 0.001) and control group (9.0 +/- 1.1 to 7.8 +/- 0.8%; P &amp;lt; 0.001) (NS between groups). Frequency of hypoglycemia (&amp;lt; 3.9 mmol/l) increased in both groups, from 0.45 +/- 0.06 to 0.69 +/- 0.07 episodes per day (P &amp;lt; 0.001) in the BGAT group and from 0.50 +/- 0.08 to 0.68 +/- 0.06 episodes per day (P &amp;lt; 0.05) in the control group NS between groups). Epinephrine responses after IDT were greater in the BGAT group (repeated measure analysis of variance [ANOVA], F = 3.5, P &amp;lt; 0.05). A separate analysis of subjects n = 26) most at risk for hypoglycemia (HbA1c after IDT &amp;lt; 7.8% or an HbA1c improvement of &amp;gt; 2 percentage points) showed that frequency of hypoglycemia increased in both the groups: from 0.50 +/- 0.09 to 0.80 +/- 0.11 episodes per day (P &amp;lt; 0.01) in the BGAT group (n = 14) and from 0.43 +/- 0.11 to 0.75 +/- 0.07 episodes per day (P &amp;lt; 0.05) in the control group (n = 12) (NS between groups). However, the epinephrine response in control subjects decreased with IDT while the response in the BGAT subjects was preserved (repeated measure ANOVA, F = 4.4, P &amp;lt; 0.02). CONCLUSIONS: BGAT is a useful intervention to decrease blunting of counterregulatory responses associated with improved glycemic control and may modify the severity of hypoglycemia associated with improved glycemic control in type 1 diabetes.
Severe Neutropenia Associated with Fluoxetine Hydrochloride
Authors: Felix D. Vilinsky
Journal: Annals of Internal Medicine (1997)

Letters1 October 1997Severe Neutropenia Associated with Fluoxetine HydrochlorideFelix D. Vilinsky, MD and Alan Lubin, MDFelix D. Vilinsky, MDMt. Sinai Medical Center; Cleveland, OH 44106 and Alan Lubin, MDMt. Sinai Medical Center; Cleveland, OH 44106Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-7-199710010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 79-year-old man, wheelchair-bound because of residual right hemiparesis from remote stroke, presented with increased fatigue, weakness, and recent history of febrile illness that had resolved spontaneously. Results of physical examination were normal except for neurologic findings related to the stroke. Medications included fluoxetine hydrochloride (Prozac, Dista Products, Indianapolis, Indiana), warfarin, glipizide, diphenhydramine, and tobramycin-dexamethasone ophthalmic drops.Hemogram showed a leukocyte count of 2800 cells/mm3 with granulocytopenia and significant monocytosis (0% segmented cells, 11% band cells, 2% metamyelocytes, 45% lymphocytes, 36% monocytes, and 6% eosinophils). Hemoglobin level (16.2 g/dL), platelet count (277 000 cells/mm3), and mean corpuscular ... Author, Article, and Disclosure InformationAuthors: Felix D. Vilinsky, MD; Alan Lubin, MDAffiliations: Mt. Sinai Medical Center; Cleveland, OH 44106 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLow-dose and repeated exposure to fluoxetine leads to eryptosis and hematological disorder in Wistar ratsSertraline-Induced Neutropenia and Fatigue in a Patient With End-Stage Renal DiseaseFluoxetineParoxetineAripiprazole-Associated Leukopenia With Coadministration of FluoxetineANTIDEPRESSANTSLeukopenia Associated with Paroxetine UseFluoxetineMonoaminergic‐based Pharmacotherapy for DepressionSafety and side effect profile of fluoxetineNeutropenia Associated with Mirtazapine Use: Is a Drop in the Neutrophil Count in a symptomatic Older Adults a Cause for Concern?Mirtazapine and bone marrow suppression: A case reportAntidepressant drugsAplastic anaemia during treatment with fluoxetineFluoxetine 1 October 1997Volume 127, Issue 7Page: 573-574KeywordsAntibodiesCellsDrug therapyLymphocytesMean corpuscular volumeMonocytesNeutropeniaNeutrophilsPlateletsStroke ePublished: 15 August 2000 Issue Published: 1 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Experience With Shortened Hospital Stay for Postsurgical Patients
Authors: Arthur Innes
Journal: JAMA (1968)

Postoperative hospital stay of 200 unselected patients who underwent either appendectomy, cholecystectomy, herniorrhaphy, or hemorrhoidectomy has been shortened by one third to one half of the customary hospital convalescence. This has been accomplished with a patient group living in a favorable sociomedical environment without detriment, and with probable benefit, to the patients and their families. The substantial shortening of hospital stay automatically increases the number of available hospital beds which at present is inadequate to meet the increasing demand.
LACK OF ANTICOAGULATION IS COMMON IN PATIENTS WITH ATRIAL FIBRILLATION WHO DEVELOP AN ISCHEMIC STROKE OR TRANSIENT ISCHEMIC ATTACK: THE FIBSTROKE STUDY
Authors: Antti Palomaki, Pirjo Mustonen, Tuija Vasankari, Ilpo Nuotio, Antti Ylitalo, Jussi Jaakkola, Riho Luite, Paivi Hartikainen, Juha Hartikainen, Juhani Airaksinen
Journal: Journal of the American College of Cardiology (2014)
Strengthening the reporting of genetic risk prediction studies: the GRIPS statement
Authors: A Cecile JW Janssens, John PA Ioannidis, Cornelia M van Duijn, Julian Little, Muin J Khoury
Journal: Genome Medicine (2011)

The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but the quality and completeness of reporting varies. A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of genetic risk prediction studies (the GRIPS statement), building on the principles established by prior reporting guidelines. These recommendations aim to enhance the transparency of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct, or analysis. A detailed Explanation and Elaboration document is published at http://www.plosmedicine.org.
The Breast Cancer Screening Controversy Continues
Authors: Anthony B. Miller
Journal: Annals of Internal Medicine (1993)

Letters1 May 1993The Breast Cancer Screening Controversy ContinuesAnthony B. Miller, MDAnthony B. Miller, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-9-199305010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Dr. Miller responds: Dr. Kopans and Dr. Logan-Young and her colleagues make several erroneous statements. Centers were chosen for the National Breast Screening Study for their expertise in mammography. Expertise in screening was not available because there was no screening program in operation in Canada at the time. Thus, the radiologists, radiographers, and nurse-examiners learned to deal with the problems of screening on the job. We simply did not have the resources to send radiologists and technologists to Rochester, New York, or indeed anywhere else for training. We documented good sensitivity and specificity of both screening modalities [1, 2] and ...References1. Baines CJ, McFarlane DV, Miller AB, and collaborating radiologists. Sensitivity and specificity of first screen mammography in 15 NBSS centres. J Can Assoc Rad. 1988; 39:273-6. Google Scholar2. Baines CJ, Miller AB, Bassett AA. Physical examination; evaluation of its role as a single screening modality in the Canadian National Breast Screening Study. Cancer. 1989; 63:160-6. Google Scholar3. Baines CJ, Miller AB, Kopans DB, Moskowitz M, Sanders DE, Sickles CA, et al. Canadian National Breast Screening Study: assessment of technical quality by external review. AJR. 1990; 155:743-7. Google Scholar4. Miller AB, Baines CJ, Sickles EA. Canadian National Breast Screening Study (Letter). AJR. 1990; 155:1133-4. Google Scholar5. Baines CJ, McFarlane DV, Miller AB. The role of the reference radiologist: estimates of inter-observer agreement and potential delay in cancer detection in the National Breast Screening Study. Invest Radiol. 1990; 25:971-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1993Volume 118, Issue 9Page: 746-749KeywordsBreast cancerBreast cancer screeningMammographyMortalityRadiologistsSpecificity ePublished: 15 August 2000 Issue Published: 1 May 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A New Method of Cleaning the Cervical Canal.
Authors: GEORGE W. NEWTON
Journal: JAMA (1901)

The difficulty experienced in trying to remove the secretion from the cervical canal before making applications thereto caused me to seek other methods than theories heretofore advised. I had a brush made as shown in the cut and the ease with which the canal can be cleaned is really surprising. It does its work perfectly, and removes equally as well the thick, yellow, gelatinous gonorrheal plug as it does one of the hematogenous variety of endocervicitis. The brush is cylindrical in shape, 1½ in. long, ¼ in. in diameter, tapering to 3/16 in. If the patient is a nullipara and has a small cervical canal a smaller brush should be used. With a pair of scissors it is a simple matter to trim the bristle off to any size desired. Several sizes should be kept on hand; as they are very inexpensive the cost is a matter of small consideration.
RAYNAUD'S DISEASE OF THE UPPER EXTREMITIES: CURE AFTER THORACIC SYMPATHECTOMY
Authors: Anatole Kolodny
Journal: JAMA (1930)

When Raynaud first described the disease subsequently named after him, he expressed an opinion that the circulatory disturbance in this disease was due to a vascular spasm. Recent microscopic study of the capillaries of the terminal phalanges of the involved extremity showed that the original suggestion of Raynaud is correct, and that the anatomic substratum of the disease is a prolonged vascular spasm due to irritation of the vasoconstrictors. Surgical treatment of this disease then suggested itself. It consists in an interruption of the path of the vasoconstrictors and in such a way in an abolition of the competition that the vasodilators have to meet. Deficient knowledge of the anatomy of the sympathetic vasotonic system up to recent years blocked the way of the evolution of surgical treatment of this disease. The periarterial sympathectomy of Leriche failed to effect a cure because of the fact that the sympathetic nerve system
P253 Pulmonary infiltrates in HIV negative immunocompromised patients: outcome and predictive factors
Authors: S. Chandramouli, M. Devine, H. Shoo, N. Duffy
Journal: Thorax (2010)

<h3>Introduction</h3> The incidence of pulmonary complications in immunocompromised patients is on the rise mainly driven by increased organ and bone marrow transplants, more aggressive chemotherapy and novel immunosuppressants.1 Mortality rates in HIV negative immunosuppressed patients vary between 40–85%.1–3 Prognostic factors have been previously described in these patients and these include need for mechanical ventilation and delay in diagnosis.2 <h3>Aims</h3> To describe the characteristics of immunocompromised HIV negative patients presenting with pulmonary infiltrates and to examine the factors that lead to increased mortality. <h3>Methods</h3> All HIV negative immunocompromised patients who had bronchoalveolar (BAL) samples taken from January 2007 to January 2010 were identified from laboratory data. Their baseline demographics, immune status, clinical presentation, radiological picture and blood results at the time of BAL sampling were obtained from hospital records. The influence of various categorical variables on mortality was evaluated using Chi-square test. Logistic regression was then used to quantify the impact of each of these variables and obtain OR. <h3>Results</h3> 87 patients (33 women) with a median (range) age of 62 (21–87) years were studied. Overall mortality was 49% (42 patients). The Abstract P253 Table 1 shows the effect of different variables on mortality. This was not affected by sex, transplant status or laboratory parameters. With logistic regression analysis, we found that haematological malignancies (OR 7.44, 1.96–28.20), long term steroids (OR 7.87, 2.36–26.20) and age &gt;65 years (OR 3.94, 1.36–11.40) were significantly associated with mortality. The relationship with immunosuppressive drugs was less significant. <h3>Conclusions</h3> HIV negative immunocompromised patients with pulmonary infiltrates are more likely to die if they have a haematological malignancy, are on long term steroid therapy or aged &gt;65 years. The effect of immunosuppressive drugs needs more elucidation. Careful attention needs to be paid to these groups of patients to pick up early signs of deterioration.
Alcohol evidence and policy
Authors: Rod MacQueen
Journal: BMJ (2004)

National Programme for Information Technology (NPfIT), has highlighted the lack of clinicians' engagement with this £6bn project.The advisory board represents a much needed injection of resources to NHS information technology systems, which could bring many benefits to care for patients and clinicians' working practices.The Wanless reports have emphasised the importance of information technology in the future of healthcare in the United Kingdom. 1 A national programme could avoid the problems around interoperability associated with past failures in NHS information technology systems.However, the secrecy surrounding the procurement phase of the programme has led to an increasing feeling of unease among clinician end users.Anxieties prevail about changes in working practices, usability of systems, training needs, and the possibility that political expediency will overshadow clinical needs.Aidan Halligan, the deputy chief medical officer, has been charged with ensuring clinical engagement with the programme. 2 The good news for the Department of Health comes from its survey, carried out by Medix, which shows that many doctors are enthusiastic about the potential of the national programme, with three quarters of respondents endorsing it as an important NHS priority. 3 Only 4% of respondents thought, however, that they had been adequately consulted.The recently announced new Front Line Support Academy aims to correct omissions at the leadership level.