tbuckley/cabot-search huggingface dataset:
Cervical and Axillary Lymph Node Sarcoidosis Misdiagnosed as Lymphoma on F-18 FDG PET-CT
Authors: Ya-Jun Li, Yue Zhang, Shuo Gao, Ren-Ju Bai
Journal: Clinical Nuclear Medicine (2007)

A 48-year-old woman without any symptoms found multiple enlarged lymph nodes in the neck and axillae for 1 year. F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)–computed tomography (CT) was performed to define the diagnosis and showed avid FDG uptake in the enlarged lymph nodes. There was no abnormal FDG uptake foci in other sites. The result was interpreted as lymphoma. Surprisingly, the histologic assessment of the surgical specimen revealed no signs of malignancy but rather sarcoidosis in the axillary lymph nodes. Many other publications have demonstrated increased FDG activity in different types of sarcoidosis but none had tracer distribution similar to our case presented here.
Poxvirus-based active immunotherapy synergizes with immune checkpoint inhibitors to cause tumor regression and extend survival in preclinical models of cancer
Authors: Susan P Foy, Ryan B Rountree, Joseph Cote, Tracy dela Cruz, Evan Gordon, Erica Trent, Alex Franzusoff, James B Breitmeyer, Stefanie J Mandl
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Combining poxvirus-based immunotherapies which "step on the gas" to activate tumor antigen-specific T cell immune responses with immune checkpoint inhibitors (ICIs) which "release the brakes" on the immune system is a promising direction for enhancing cancer immunotherapy.
DNA methylation in schizophrenia: progress and challenges of epigenetic studies
Authors: Masaki Nishioka, Miki Bundo, Kiyoto Kasai, Kazuya Iwamoto
Journal: Genome Medicine (2012)

Schizophrenia is a severe psychiatric disease affecting about 1% of the world's population, with significant effects on patients and society. Genetic studies have identified several candidate risk genes or genomic regions for schizophrenia, and epidemiological studies have revealed several environmental risk factors. However, the etiology of schizophrenia still remains largely unknown. Epigenetic mechanisms such as DNA methylation and histone modifications can explain the interaction between genetic and environmental factors at the molecular level, and accumulating evidence suggests that such epigenetic alterations are involved in the pathophysiology of schizophrenia. However, replication studies to validate previous findings and investigations of the causality of epigenetic alterations in schizophrenia are needed. Here, we review epigenetic studies of schizophrenia patients using postmortem brains or peripheral tissues, focusing mainly on DNA methylation. We also highlight the recent progress and challenges in characterizing the potentially complex and dynamic patterns of epigenomic variations. Such studies are expected to contribute to our understanding of schizophrenia etiology and should provide novel opportunities for the development of therapeutic drugs.
Combination of Sumatriptan and Naproxen for Migraine
Authors: Kevin P. Hill, Omotola Hope
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE EFFECT OF HEMOPHILUS INFLUENZAE SUIS VACCINES ON SWINE INFLUENZA
Authors: Richard E. Shope
Journal: The Journal of Experimental Medicine (1937)

Either living or heat-killed H. influenzae suis vaccines, given intramuscularly to swine, elicit an immune response capable of modifying the course of a later swine influenza infection. The protection afforded is only partial and is in no way comparable to the complete immunity afforded by swine influenza virus vaccines.
Mucin-vesicle interactions in model bile: Evidence for vesicle aggregation and fusion before cholesterol crystal formation
Authors: Nezam H. Afdhal, Niu Niu, David P. Nunes, Rama Bansil, Xing Xiang Cao, Donald Gantz, Donald M. Small, Gwynneth D. Offner
Journal: Hepatology (1995)

Nucleation of cholesterol monohydrate crystals from bile is a critical step in the formation of cholesterol gallstones. Measurement of nucleation in model bile system and the characteristics of the initial nucleus have proven elusive. In this study we have used three separate physical chemical techniques to examine vesicle aggregation and fusion, including dynamic light scattering (DLS), transmission electron microscopy (TEM), and fluorescent biochemical assays. These assays enabled us to quantify the effect of biliary proteins, such as gallbladder mucin, on vesicle fusion and aggregation. In the absence of mucin, fusion is a relatively slow process occurring over 24 hours, whereas physiological concentrations of mucin are able to accelerate almost complete fusion of vesicles within 6 hours. Vesicle fusion and aggregation as characterized by TEM result in the formation of aggregates of multilamellar vesicles and giant fusion bodies associated with a background of mucin. These mucin-vesicle aggregate bodies may represent true nuclei and precede cholesterol monohydrate crystal nucleation. In future studies, these vesicle fusion assays can be used to quantitatively examine the effect of putative pro- and anti-nucleating proteins on the earliest steps of cholesterol crystal nucleation.
Criticism of a Medical Directory.
Authors: A. N. Shotwell
Journal: JAMA (1898)

Mount Clemens, Mich., Sept. 22, 1898.  To the Editor:  —There has been a question coming up from time to time as to the reliability of the information published by R. L. Polk & Co., in their Medical and Surgical Register of the United States. This question has been discussed pro and con , some claiming that it was reliable and others that it was not. It has come to the notice of physicians generally that the names of men were inserted as practicing physicians, whose evidences of having graduated were rather shady; but not until the present year have I known of any instance where they have sought to compel physicians to buy their publication by giving them a bad standing before the public if they did not. That seems to have been done in my case in the present edition without any other motive (further than that as treasurer of
Prevention of dermatitis and its medico-legal aspects
Authors: RONALD CHURCH
Journal: British Journal of Dermatology (1981)

Journal Article Prevention of dermatitis and its medico‐legal aspects Get access RONALD CHURCH RONALD CHURCH Rupert Hallam Department of Dermatology, Royal Hallamshire Hospital, Sheffield Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue s21, 1 September 1981, Pages 85–90, https://doi.org/10.1111/j.1365-2133.1981.tb01317.x Published: 01 September 1981
Sudden death during ambulatory monitoring. Clinical and electrocardiographic correlations. Report of a case.
Authors: A H Gradman, P A Bell, R F DeBusk
Journal: Circulation (1977)

A man with known coronary heart disease underwent treadmill exercise testing to determine his functional capacity. The test was negative for ischemia. Ventricular ectopic activity was noted at rest and in the recovery period. On the same day, while viewing a sporting event at home, the patient died suddenly. An ambulatory electrocardiographic recording documented ventricular fibrillations as the terminal mechanism. Ventricular ectopic activity and heart rate increased in the two hours prior to death, and ischemic ST-segment depression was noted at the time of the terminal arrhythmia. It is postulated that myocardial ischemia and catecholamine response lowered the threshold to ventricular fibrillation, thus facilitating the emergence of the fatal arrhythmia.
Successful treatment of severe aplastic anemia associated with human parvovirus B19 and Epstein‐Barr virus in a healthy subject with allo‐BMT
Authors: Kürşad Kaptan, Cengiz Beyan, Ali Uğur Ural, Celalettin Üstün, Türker Çetin, Ferit Avcu, Ayhan Kubar, Metin Alış, Atilla Yalçın
Journal: American Journal of Hematology (2001)

Abstract Several reports have noted pancytopenia associated with Human parvovirus B19 (PVB19) or Ebstein‐Barr virus (EBV) infections in patients who have no history of immunodeficiency. To our knowledge, we report the first case of severe aplastic anemia associated with both EBV and PVB19 infections in a previously healthy 22‐year‐old man. He was admitted to our hematology service due to anemia and thrombocytopenia. He had no symptoms or signs of infections of these viruses. His bone marrow biopsy revealed a hypocellular marrow. Specific IgM and IgG antibodies to EBV and PVB19 were elevated. EBV and PVB19 virus genomes were detected by PCR in the bone marrow nucleated cells and the peripheral blood lymphocytes. Two months after treatment with prednisone, acyclovir, and intravenous immune globulin (IVIg), the genomes of both these viruses disappeared. However, his transfusion requirement for platelet suspensions and packed red blood cells persisted. The patient underwent allogeneic bone marrow transplant (allo‐BMT) and has had an enduring complete hematological response for 8 months. Am. J. Hematol. 67:252–255, 2001. © 2001 Wiley‐Liss, Inc.
Intranasal lidocaine for treatment of migraine
Authors: A. Tulchinsky
Journal: JAMA (1996)

<h3>To the Editor.</h3> —I am concerned that the study by Dr Maizels et al<sup>,</sup>which shows efficacy for intranasal lidocaine in the treatment of migraine headaches, is a demonstration of the ability of therapy to show a positive response rate when the treatment and placebo are not equivalent. This is an important issue regarding this double-blind randomized controlled study, because intranasal lidocaine is highly irritative and can easily be distinguished from the relatively benign and comfortable instillation of saline that was used as a control. It is reasonable to expect that the treatment that causes more irritation might cause a higher placebo response rate, as has been demonstrated in several reviews of placebo pharmacology.<sup>3,4</sup>Patients tend to perceive larger capsules of placebo as being stronger than smaller ones, 2 placebo capsules as producing stronger effects than just 1,<sup>2</sup>and injections as producing larger placebo effects than pills.<sup>3,4</sup> The literature on
Codon 102 of the Cardiac Troponin T Gene Is a Putative Hot Spot for Mutations in Familial Hypertrophic Cardiomyopathy
Authors: Jean-Franc¸ois Forissier, Lucie Carrier, Hend Farza, Gise`le Bonne, Josiane Bercovici, Pascale Richard, Bernard Hainque, Philip J. Townsend, Magdi H. Yacoub, Sabine Faure´, Olivier Dubourg, Alain Millaire, Albert A. Hage`ge, Michel Desnos, Michel Komajda, Ketty Schwartz
Journal: Circulation (1996)

Familial hypertrophic cardiomyopathy is a phenotypically and genetically heterogeneous disease. In some families, the disease is linked to the CMH2 locus on chromosome 1q3, in which the cardiac troponin T gene (TNNT2) has been identified as the disease gene. The mutations found in this gene appear to be associated with incomplete penetrance and poor prognosis. Because mutational hot spots offer unique possibilities for analysis of genotype-phenotype correlations, new missense mutations that could define such hot spots in TNNT2 were looked for in unrelated French families with familial hypertrophic cardiomyopathy.Family members were genotyped with microsatellite markers to detect linkage to the four known disease loci. In family 715, analyses showed linkage to CMH2 only. To accurately position potential mutations on TNNT2, its partial genomic organization was established. Screening for mutations was performed by single-strand conformation polymorphism analysis and sequencing. A new missense mutation, Arg102Leu, was identified in affected members of family 715 because of a G-->T transversion located in the 10th exon of the gene. Penetrance of this new mutation is complete; echocardiographic data show a wide range of hypertrophy; and there was no sudden cardiac death in this family.The codon 102 of the TNNT2 gene is a putative mutational hot spot in familial hypertrophic cardiomyopathy and is associated with phenotypic variability. Analysis of more pedigrees carrying mutations in this codon is necessary to better characterize the clinical and prognostic implications of TNNT2 mutations.
Lumbar Puncture in Poliomyelitis
Authors: Simon Flexner
Journal: JAMA (1910)

<h3>To the Editor:—</h3> The reason for recommending that lumbar puncture be performed in cases of doubtful infantile paralysis is in order to arrive at the earliest practical moment at a correct diagnosis. We are still very ignorant of the real extent of the epidemics of poliomyelitis and are therefore, prevented from exercising due caution in limiting its spread. What we need especially to learn is the frequency with which cases of poliomyelitis that do not develop paralysis occur, and what the leading symptoms are in these instances, since the socalled abortive cases may be found to be the insidious means of the transmission of the infection. Moreover, there occurs, not uncommonly, a form of anterior poliomyelitis which simulates epidemic meningitis so closely as to be frequently confused with that disease. I can speak with certain knowledge on this point because of the frequency
Tc-99m MDP Uptake in Liver Metastases from Adenocarcinoma of the Duodenum
Authors: Serpil Erdogan, Sabri Barutca, Yakup Yurekli
Journal: Clinical Nuclear Medicine (2004)

A 45-year-old man with histopathologically confirmed adenocarcinoma of the duodenum underwent Tc-99m methylene diphosphonate bone scintigraphy to evaluate possible bone metastases. Both abdominal ultrasonography and CT showed hepatomegaly and massive metastases in the liver with multiple areas of tumor necrosis. Liver biopsy established the diagnosis of liver metastases from adenocarcinoma. Bone scintigraphy revealed multiple areas of increased uptake in the liver, consistent with multiple hepatic metastases.
Identification of Mycobacterium marinum in sea-urchin granulomas
Authors: C. De La Torre, A. Vega, A. Carracedo, J. Toribio
Journal: British Journal of Dermatology (2001)

Sea-urchin granuloma is a chronic granulomatous reaction arising after injury with sea-urchin spines. Classified as an allergic foreign-body type of granuloma, it is believed to be a delayed-type reaction to an as yet unidentified antigen. In a clinicopathological study, 50 biopsy specimens from 35 patients diagnosed as having sea-urchin granuloma caused by Paracentrotus lividus, we found different inflammatory patterns that in some cases suggested a mycobacterial infection.To investigate and identify mycobacterial DNA in formalin-fixed and paraffin-embedded skin biopsy specimens diagnosed as sea-urchin granulomas.A search combining polymerase chain reaction amplification using Mycobacterium genus-specific primers, and subsequent restriction enzyme analysis enabling identification to the species level, was performed in 41 samples.Amplification of a 924-bp DNA fragment encoding mycobacterial 16S rRNA gene was positive in eight biopsy specimens from seven patients (21%). M. marinum-specific restriction patterns were identified in three samples.Although further controlled studies are necessary, from these data it would appear that mycobacteria may play a pathogenic role in some cases of sea-urchin granuloma.
The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes
Authors: R Bomben, S Gobessi, M Dal Bo, S Volinia, D Marconi, E Tissino, D Benedetti, A Zucchetto, D Rossi, G Gaidano, G Del Poeta, Luca Laurenti, Dg Efremov, V. Gattei
Journal: Leukemia (2012)
Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy
Authors: Noah Weisleder, Norio Takizawa, Peihui Lin, Xianhua Wang, Chunmei Cao, Yan Zhang, Tao Tan, Christopher Ferrante, Hua Zhu, Pin-Jung Chen, Rosalie Yan, Matthew Sterling, Xiaoli Zhao, Moonsun Hwang, Miyuki Takeshima, Chuanxi Cai, Heping Cheng, Hiroshi Takeshima, Rui-Ping Xiao, Jianjie Ma
Journal: Science Translational Medicine (2012)

Recombinant human MG53 protein can increase membrane repair after injury in cells and can reduce pathology in animal models of muscle injury and muscular dystrophy.
Transitions Between Care Settings at the End of Life in Belgium
Authors: Lieve Van den Block, Reginald Deschepper, Johan Bilsen, Viviane Van Casteren, Luc Deliens
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor Stenoses of the Upper Gastrointestinal Tract - Therapeutic Alternatives to Laser Therapy
Authors: G. Lux, H. Groitl, Ch. Ell
Journal: Endoscopy (1986)

Alternatives to laser treatment of tumor stenoses of upper gastrointestinal tract include dilatation, implantation of bridging tubes, radiation therapy and chemotherapy. Based on the experience of 170 bridging tubes implanted and laser therapy in 70 patients with tumor stenoses (presented elsewhere) "tubes and laser" are compared. Complication rate, applicability in very proximal and distal stenoses are in favour of laser therapy, costs, hospitalisation time, possibility to occlude fistulae and short recurrence time after laser therapy are facts speaking for oesophageal bridging tubes. The question "tubes or laser" has to be answered by "tubes and laser" already.
Cryptosporidiosis in Hospital Personnel
Authors: Kenneth L. Koch, Debra J. Phillips, Robert C. Aber, William L. Current
Journal: Annals of Internal Medicine (1985)

An intern responsible for the care of a patient with chronic cryptosporidiosis developed acute diarrhea and serologic evidence of Cryptosporidium infection. Sera from 26 hospital personnel exposed to the patient and 18 personnel with no exposure were examined with an indirect immunofluorescent antibody procedure for the presence of antibodies to Cryptosporidium. Eight (31%) exposed personnel—5 nurses, 2 house officers, and 1 student—had positive antibody titers (1:10 or more). The frequency of positivity in the nurse-housestaff-student group (8 of 18, 45%) was significantly greater (p < 0.05) than that in the attending physicians and respiratory therapists (0 of 8). The former group had significantly more exposure to the patient's feces than did the latter group (p < 0.01). Three of eighteen control personnel (17%) had positive Cryptosporidium antibody titers. These findings suggest that Cryptosporidium may be transmitted from person to person in the hospital environment and that serologic evidence of infection is common among hospital personnel.
Clinical and Radiographic Predictors of GOLD–Unclassified Smokers in the COPDGene Study
Authors: Emily S. Wan, John E. Hokanson, James R. Murphy, Elizabeth A. Regan, Barry J. Make, David A. Lynch, James D. Crapo, Edwin K. Silverman
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Rationale: A significant proportion of smokers have lung function impairment characterized by a reduced FEV1 with a preserved FEV1/FVC ratio. These smokers are a poorly characterized group due to their systematic exclusion from chronic obstructive pulmonary disease (COPD) studies.Objectives: To characterize the clinical, functional, and radiographic features of Global Initiative for Chronic Obstructive Lung Disease (GOLD)-Unclassified (FEV1/FVC ≥ 0.7 and FEV1 < 80% predicted) and lower limits of normal (LLN)-unclassified (FEV1/FVC ≥ LLN and FEV1 < LLN) subjects compared to smokers with normal lung function and subjects with COPD.Methods: Data from the first 2,500 subjects enrolled in the COPDGene study were analyzed. All subjects had 10 or more pack-years of smoking and were between the ages of 45 and 80 years. Multivariate regression models were constructed to determine the clinical and radiological variables associated with GOLD-Unclassified (GOLD-U) and LLN-Unclassified status. Separate multivariate regressions were performed in the subgroups of subjects with complete radiologic measurement variables available.Measurements and Main Results: GOLD-U smokers account for 9% of smokers in COPDGene and have increased body mass index (BMI), a disproportionately reduced total lung capacity, and a higher proportion of nonwhite subjects and subjects with diabetes. GOLD-U subjects exhibit increased airway wall thickness compared to smoking control subjects and decreased gas trapping and bronchodilator responsiveness compared to subjects with COPD. When LLN criteria were used to define the “unclassified” group, African American subjects were no longer overrepresented. Both GOLD-U and LLN-Unclassified subjects demonstrated a wide range of lung function impairment, BMI, and percentage of total lung emphysema.Conclusions: Subjects with reduced FEV1 and a preserved FEV1/FVC ratio are a heterogeneous group with significant symptoms and functional limitation who likely have a variety of underlying etiologies beyond increased BMI.Clinical trial registered with www.clinicaltrials.gov (NCT000608764).