Genetics, Alcohol, and Cirrhosis
Authors: Elisabetta Ceni
Journal: Annals of Internal Medicine (1997)

Letters15 June 1997Genetics, Alcohol, and CirrhosisElisabetta Ceni, PhD, Andrea Galli, MD, and Alessandro Casini, MDElisabetta Ceni, PhDUniversita di Firenze, 50134 Firenze, ItalySearch for more papers by this author, Andrea Galli, MDUniversita di Firenze, 50134 Firenze, ItalySearch for more papers by this author, and Alessandro Casini, MDUniversita di Firenze, 50134 Firenze, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-12-199706150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Ethanol is almost completely metabolized by oxidative metabolism in humans. Alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and cytochrome P4502E1 (CYP2E1) are the primary enzymes that catalyze the conversion of ethanol to acetaldehyde and then to acetate. Genetic polymorphisms have been reported in the ADH2, ADH3, and ALDH2 loci and in the 5′-flanking region of CYP2E1 [1]. Such polymorphisms might play a role in an individual's susceptibility to alcoholic liver disease [2]. The aim of our study was to determine whether genetic polymorphism influences the severity of alcoholic liver disease in Italian patients.One hundred persons with chronic ...References1. Yoshida A, Hsu LC, Yasunami M. Genetics of human alcohol metabolizing enzymes. Prog Nucleic Acid Res Mol Biol. 1991; 40:255-87. Google Scholar2. Lumeng L, Crabb DW. Genetic aspects and risk factors in alcoholism and alcoholic liver disease. Gastroenterology. 1994; 107:572-8. Google Scholar3. Groppi A, Begueret J, Iron A. Improved methods for genotype determination of human alcohol dehydrogenase (ADH) at ADH2 and ADH3 loci by using polymerase chain reaction-directed mutagenesis. Clin Chem. 1990; 36:1765-8. Google Scholar4. Chao YC, Liou SR, Chung YY, Tang HS, Hsu CT, Li TK, et al. Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients. Hepatology. 1994; 19:360-6. Google Scholar5. Hayashi S, Watanabe J, Kawajiri K. Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J Biochem. 1991; 110:559-65. Google Scholar Author, Article, and Disclosure InformationAffiliations: Universita di Firenze, 50134 Firenze, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByReview of Pathophysiological Aspects and Risk Factors for Liver DysfunctionAre genes really important in alcoholic liver disease?Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individualsReview article: alcoholic liver disease ? pathophysiological aspects and risk factorsTHE ROLE OF GENETIC POLYMORPHISMS IN ALCOHOLIC LIVER DISEASEGenetic Polymorphism of CYP2E1 and Digestive Tract Alcohol Damage Among Polish IndividualsEffects of alcohol on skeletal and cardiac muscleGenetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver diseaseGenetic Determinants of Alcohol Addiction and Metabolism: A Survey in Italy 15 June 1997Volume 126, Issue 12Page: 1000KeywordsAlcoholsCirrhosisEnzymesEthanolFatty liverGenetic polymorphismLiverLiver diseasesLiver fibrosisPolymerase chain reaction Issue Published: 15 June 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...