An Evaluation of the Tetracycline-fluorescence Test in the Diagnosis of Gastric Cancer
Authors: ALVIN J. CUMMINS
Journal: Annals of Internal Medicine (1964)

Article1 July 1964An Evaluation of the Tetracycline-fluorescence Test in the Diagnosis of Gastric CancerComparison with CytologyALVIN J. CUMMINS, M.D., F.A.C.P., MICHAEL L. GOMPERTZ, M.D., F.A.C.P., JOHN H. KIER, M.D.ALVIN J. CUMMINS, M.D., F.A.C.P.Search for more papers by this author, MICHAEL L. GOMPERTZ, M.D., F.A.C.P.Search for more papers by this author, JOHN H. KIER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-1-56 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is great need for a simple reliable test for the detection of gastric malignancy and its differentiation from benign lesions. Recently, several investigators have reported on the use of tetracycline fluorescence of the gastric sediment in such detection and most of the reports have indicated a rather high degree of diagnostic accuracy (1-4).The tetracycline drugs are known to fluoresce bright yellow in ultraviolet light of 3,600 Å, and this observation has been used to trace the absorption and distribution of the drug (5). Tetracycline-induced fluorescence disappears from normal tissues, except bone and teeth, within 24 hours (6, 7)....References1. KLINGERKATZ JR: Tetracycline fluorescence in the diagnosis of gastric carcinoma. Gastroenterology 41: 29, 1961. CrossrefMedlineGoogle Scholar2. BERKKANTOR JESM: Demethylchlortetracycline-induced fluorescence of gastric sediment—use to differentiate benign and malignant gastric lesions. JAMA 179: 997, 1962. CrossrefMedlineGoogle Scholar3. SANDLOWALLENNECHELES LJHAH: The use of tetracycline fluorescence in the detection of gastric malignancy. Ann. Intern. Med. 58: 409, 1963. LinkGoogle Scholar4. SHERMANCHRYSSANTHOUSUKOFFMININBERGBECKMANWEINGARTEN HHCMHDEMM: Tetracycline fluorescence in the diagnosis of gastric carcinoma. Gastroenterology 45: 84, 1963. CrossrefMedlineGoogle Scholar5. BOTTINGER LE: On the distribution of tetracycline in the body. Antibiot. Chemother. (NY) 5: 332, 1955. MedlineGoogle Scholar6. RALLLOOLANEKELLY DPTLMMG: Appearance and persistence of fluorescent material in tumor tissue after tetracycline administration. J. Nat. Cancer Inst. 19: 79, 1957. MedlineGoogle Scholar7. MILCHRALLTOBIE RADPJE: Bone localization of the tetracyclines. Ibid., p. 87. Google Scholar8. VASSARSAUNDERSCULLING PSAMCF: Tetracycline fluorescence in malignant tumors and benign ulcers. Arch. Path. (Chicago) 69: 613, 1960. MedlineGoogle Scholar9. PHILLIPSCOBBRICHARDSRHODESLOEHRERRITCHIE JWEGVWDDCJL: The deposition and retention of tetracycline in cancer. Amer. J. Surg. 100: 384, 1960. CrossrefMedlineGoogle Scholar10. ABERLE S: The tetracycline fluorescence test in the differential diagnosis of gastric disease (abstract). Gastroenterology 44: 813, 1963. CrossrefGoogle Scholar11. WORSLEYMCKENNABECK GHRDIT: Critical evaluation of the tetracycline fluorescence test in the diagnosis of gastric carcinoma. Canad. Med. Ass. J. 88: 1272, 1963. MedlineGoogle Scholar12. RASKINKIRSNERPALMER HFJBWL: Exfoliative cytology of the gastrointestinal tract, in Modern Trends in Gastroenterology, series 2, edited by JONES, F. A., Paul B. Hoeber, Inc., New York, 1958. Google Scholar13. KRAUSCASEYJOHNSON FWDWV: Aureomycin and Terramycin in human saliva. Proc. Soc. Exp. Biol. Med. 78: 554, 1951. CrossrefMedlineGoogle Scholar14. ABERLE S: Basal gastric secretions: a study in yellow orange fluorescence. JAMA 185: 777, 1963. CrossrefMedlineGoogle Scholar15. BERNHARDTKILLIANEASTRIDGE HJJC: Gastric washings as a source of malignant cells from bronchial secretions. JAMA 183: 485, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALVIN J. CUMMINS, M.D., F.A.C.P.; MICHAEL L. GOMPERTZ, M.D., F.A.C.P.; JOHN H. KIER, M.D.Affiliations: Memphis, TennesseeFrom the Department of Medicine, University of Tennessee College of Medicine, the John Gaston Hospital, and the Gastroenterology Section of the Medical Service, Veterans Administration Hospital, Memphis, Tennessee.Requests for reprints should be addressed to Alvin J. Cummins, M.D., Professor of Medicine, University of Tennessee College of Medicine, 858 Madison Avenue, Memphis 3, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBösartige GeschwülsteQuantitative studies on the accumulation of tetracycline in tumorsDegree of fluorescence in the prognosis of malignant tumorsTetracycline fluorescence and cytological procedures compared for the detection of malignancy.Gastric Ulcer or Gastric Cancer ?Comparison of tetracycline-induced fluorescence test and exfoliative cytology of gastric contentTetracycline Fluorescence of Pathologic Pulmonary Tissues 1 July 1964Volume 61, Issue 1Page: 56-63KeywordsDrug absorptionDrug distributionDrugsGratitudeHospital medicineIngestionLesionsMedical servicesSalivaTetracyclines ePublished: 1 December 2008 Issue Published: 1 July 1964 PDF downloadLoading ...