Biochemical Abnormalities in Hereditary Diseases
Authors: JOSEPH J. BUNIM
Journal: Annals of Internal Medicine (1962)

Clinical Staff Conference1 September 1962Biochemical Abnormalities in Hereditary DiseasesJOSEPH J. BUNIM, M.D., F.A.C.P., ROBERT S. KROOTH, M.D., ARNOLD WEINBERG, M.D., R. RODNEY HOWELL, M.D., BERT N. LA DU, M.D., J. E. SEEGMILLER, M.D.JOSEPH J. BUNIM, M.D., F.A.C.P.Search for more papers by this author, ROBERT S. KROOTH, M.D.Search for more papers by this author, ARNOLD WEINBERG, M.D.Search for more papers by this author, R. RODNEY HOWELL, M.D.Search for more papers by this author, BERT N. LA DU, M.D.Search for more papers by this author, J. E. SEEGMILLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-3-472 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Joseph J. Bunim: In a recent Harvey lecture (1), Dr. James V. Neel stated that "The ultimate basis of biogenetic traits resides in some 20 thousand pairs of genes. The term gene refers to that functional subdivision of chromosomes which conveys a unit biochemical message." To be able to intercept this message and to interpret it in precise biochemical language by means of growing human cell lines in tissue culture and by quantitatively analyzing their enzymatic contents, is a breakthrough in human genetics of considerable magnitude and even greater promise.Soon after Dr. Robert Krooth came to the National...References1. NEEL JV: A geneticist looks at modern medicine. The Harvey Lectures, Series 56, Academic Press, New York, 1960-61, p. 127. Google Scholar2. LEVINTOWEAGLE LH: Biochemistry of cultured mammalian cells. Ann. Rev. Biochem. 30: 605, 1961. CrossrefGoogle Scholar3. SATOZAROFFMILLS GLSE: Tissue culture populations and their relation to the tissue of origin. Proc. Nat. Acad. Sci. 46: 963, 1960. CrossrefMedlineGoogle Scholar4. GARTLER S: A study of the glucose-6-phosphate dehydrogenase mutant in cell culture. 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Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandThis is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Maryland, by the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.Requests for reprints should be addressed to Joseph J. Bunim, M.D., National Institute of Arthritis and Metabolic Diseases, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCystinosis Combined Clinical Staff Conference at the National Institutes of HealthJ. EDWIN SEEGMILLER, M.D., THEODORE FRIEDMANN, M.D., HAROLD E. HARRISON, M.D., VERNON WONG, M.D., JERRY A. SCHNEIDER, M.D.Heredity of gout and hyperuricemiaMedical genetics 1962Biochemistry of Uric Acid and Its Relation to Gout 1 September 1962Volume 57, Issue 3Page: 472-497KeywordsChromosomesGenetic diseasesGeneticsHuman geneticsInfantsMedical servicesMetabolic disordersPrevention, policy, and public healthTissue culturesUric acid Issue Published: 1 September 1962 PDF downloadLoading ...