tbuckley/cabot-search huggingface dataset:
Flow-independent Nitric Oxide Exchange Parameters in Cystic Fibrosis
Authors: HYE-WON SHIN, CHRISTINE M. ROSE-GOTTRON, RAMINDRJIT S. SUFI, FEDERICO PEREZ, DAN M. COOPER, ARCHIE F. WILSON, STEVEN C. GEORGE
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Exhaled nitric oxide (NO) remains a promising noninvasive index for monitoring inflammatory lung diseases; however, the plateau concentration (CNO,plat) is nonspecific and requires a constant exhalation flow rate. We utilized a new technique that employs a variable flow rate to estimate key flow-independent parameters characteristic of NO exchange in a group (n = 9) of 10 to 14 yr-old healthy children and children with cystic fibrosis (CF): maximum flux of NO from the airways (JNO,max, pl s− 1), diffusing capacity of NO in the airways (DNO,air, pl s− 1 ppb− 1), steady-state alveolar concentration (Calv,ss, ppb), and mean tissue concentration of NO in the airways (Ctiss,air, ppb). We determined the following mean ( ± SD) values in the healthy children and patients with CF for JNO,max, DNO,air, Calv,ss, and Ctiss,air, respectively: 784 ± 465 and 607 ± 648 pl s− 1; 4.82 ± 3.07 and 17.6 ± 12.1 pl s− 1 ppb− 1; 4.63 ± 3.59 and 1.96 ± 1.18 ppb; and 198 ± 131 and 38 ± 25 ppb. DNO,air is elevated (p = 0.007), and both Calv,ss and Ctiss,air are reduced (p = 0.05 and 0.002, respectively) in CF. In contrast, CNO,plat for healthy control subjects and patients with CF are not statistically different at both exhalation flow rates of 50 ml/s (17.5 ± 11.5 and 11.5 ± 8.97) and at 250 ml/s (7.11 ± 5.36 and 4.28 ± 3.43). We conclude that DNO,air, Ctiss,air, and Calv,ss may be useful noninvasive markers of CF.
Exanthematous lichen planus in a child - response to acitretin
Authors: K. Brockow, D. Abeck, G. Haupt, J. Ring
Journal: British Journal of Dermatology (1997)

Journal Article Exanthematous lichen planus in a child – response to acitretin Get access K. Brockow, K. Brockow Universitäts–Hautklinik Hamburg–Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.Dermatologische Klinik und Poliklinik am Biederstein, Technische Universität München, Biedersteiner Strasse 29, 80802 München, Germany Search for other works by this author on: Oxford Academic Google Scholar D. Abeck, D. Abeck Universitäts–Hautklinik Hamburg–Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.Dermatologische Klinik und Poliklinik am Biederstein, Technische Universität München, Biedersteiner Strasse 29, 80802 München, Germany Search for other works by this author on: Oxford Academic Google Scholar G. Haupt, G. Haupt Universitäts–Hautklinik Hamburg–Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. Search for other works by this author on: Oxford Academic Google Scholar J. Ring J. Ring Universitäts–Hautklinik Hamburg–Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.Dermatologische Klinik und Poliklinik am Biederstein, Technische Universität München, Biedersteiner Strasse 29, 80802 München, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 2, 1 February 1997, Pages 287–288, https://doi.org/10.1111/j.1365-2133.1997.tb14918.x Published: 01 February 1997
FBI Assigns Agents to Combat Health Care Fraud
Authors: Charles Marwick
Journal: JAMA (1992)

THE JUSTICE DEPARTMENT is strengthening its attack on civil and criminal fraud in the health care industry. Fifty agents from the department's Federal Bureau of Investigation have been transferred to newly formed health care fraud units being established in 12 cities where such fraud is held to be most serious. <h3>12 Cities Targeted</h3> The cities are Baltimore, Md, Charlotte, NC, Chicago, Ill, Dallas, Tex, Detroit, Mich, Las Vegas, NV, Los Angeles, Calif, Miami, Fla, New York, NY, Newark, NJ, New Orleans, La, and Philadelphia, Pa. The agents join about 100 assistant US attorneys dealing with civil and criminal health care fraud matters. A report from George J. Terwilliger III, acting deputy attorney general, mentions false billings, unnecessary tests and services, abuse of controlled substances, kickbacks and bribes, false cost reporting, staged accidents, false testing, and price fixing. No one, least of all the Department of Justice, seems to have a
TREATMENT OF THYROTOXICOSIS
Authors: Thomas A. Groover
Journal: JAMA (1930)

<h3>To the Editor:</h3> —In Queries and Minor Notes (The Journal, June 28, p. 2085), a correspondent asks advice as to "the treatment of patients with thyrotoxicosis who will not submit to surgery." Your answer indicates that the nonsurgical treatment of thyrotoxicosis is of little or no value and concludes with the statement that "the physician in charge has a definite responsibility imposed on him to influence such patients to submit to an operation." Your answer, of course, is quite in harmony with the surgical point of view, but you ignore the fact that many able clinicians do not subscribe to that point of view, at least, without more or less latitudinous reservations. As an example of the latter I quote the following concerning [ill]e medical treatment of hyperthyroidism from Osler's Practice of Medicine, edition 10, page 901: It is usually well to try medical treatment before surgery is considered. Halfway
Sleep-Disordered Breathing and Cognitive Impairment in Older Women--Reply
Authors: K. Yaffe, K. L. Stone
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma histamine in asthmatic and control subjects following exercise: influence of circulating basophils and different assay techniques.
Authors: D J Morgan, I Moodley, M J Phillips, R J Davies
Journal: Thorax (1983)

Arterial plasma histamine concentrations were measured after exercise in 10 subjects with extrinsic atopic asthma, 10 who were non-atopic and non-asthmatic and seven who were atopic but non-asthmatic, by a single isotope radioenzymatic assay. Significantly higher plasma histamine concentrations were found in the asthmatic subjects before exercise than in the non-atopic controls (p less than 0.05). The mean histamine concentration rose after exercise in all groups but the increased levels were not significantly different from pre-exercise values. Similarly, mean circulating basophil counts increased in all groups after exercise, and a highly significant correlation was found between basophil counts and whole blood histamine concentrations (p less than 0.001). In vitro studies showed that there was a significant correlation between the number of basophils added to plasma samples and the concentrations of histamine subsequently detected. Although the mean concentrations of plasma histamine and whole blood histamine and number of basophils in the atopic control group were intermediate between those found in the atopic asthmatic and non-atopic controls, none of the differences was significant. Venous plasma histamine concentrations after exercise were measured in a further five subjects with extrinsic atopic asthma and five non-atopic, non-asthmatic subjects before and after exercise with the more sensitive and specific double isotope radioenzymatic assay. Concentrations of plasma histamine measured by this assay were about one tenth of those measured by the single isotope radioenzymatic assay. Although a small rise in mean plasma histamine concentration occurred in both groups after exercise there was no significant difference in these levels either between or within the groups. We find no evidence from these studies on measurement of peripheral blood histamine to support the hypothesis that mast cell mediator release is implicated in the pathogenesis of exercise induced asthma.
The Effect of Balloon Angioplasty on Hypertension in Atherosclerotic Renal-Artery Stenosis
Authors: Brigit C. van Jaarsveld, Pieta Krijnen, Herman Pieterman, Frans H.M. Derkx, Jaap Deinum, Cornelis T. Postma, Ad Dees, Arend J.J. Woittiez, Anton K.M. Bartelink, Arie J. Man in `t Veld, Maarten A.D.H. Schalekamp
Journal: New England Journal of Medicine (2000)

Patients with hypertension and renal-artery stenosis are often treated with percutaneous transluminal renal angioplasty. However, the long-term effects of this procedure on blood pressure are not well understood.
Cushing's Syndrome Treated by Removal of Adrenal-Cortex Tumor
Authors: Frederick L. Nichols, Sophie A. Root, Charles S. Mirabile, R. Starr Lampson
Journal: New England Journal of Medicine (1952)

CUSHING'S syndrome is the broad term describing a definite clinical entity that may result from any one of several different causes. In this condition the common denominator, which gives rise to the signs and symptoms, is overproduction of adrenal cortical hormones with their typical effects on sexuality, electrolytes and carbohydrate metabolism.Originally Cushing called attention to this clinical picture in cases in which he found basophilic pituitary tumors or an increase in the basophilic cells throughout the anterior pituitary. This particular subgroup of Cushing's syndrome has therefore been given the name of Cushing's disease. In these cases the basophilic cells . . .
Automatic Clotting-timer for Control of Anticoagulant Therapy
Authors: M. Toohey, I. J. Y. Cook
Journal: BMJ (1960)

BRDICALJOURNAL carpal tunnel.Further swelling slowly developed, together with acute tenderness both in the palm and just above the transverse carpal ligament on the front of the wrist.There was almost complete loss of median-nerve sensation in the thumb and index and middle fingers.Motor function of the short thenar muscles could not be tested because of the extreme swelling and tenderness.On January 7 it was decided to explore the front of the wrist.Operation.-This was performed by Mr. A. Gourevitch under general anaesthesia, in a bloodless field.An incision was made along the ulnar border of the wrist, and Parona's space was opened.The tissues were all oedematous and a small quantity of blood-stained exudate was evacuated.A second incision was made, curving round the base of the thenar eminence and up to the distal wrist-crease.The palmar fascia and transverse carpal ligament were exposed.The latter was divided completely, exposing the median nerve.No macroscopic evidence of compression was noted, but some further blood-stained fluid was evacuated from here and from the mid-palmar space, which was explored by an incision through the palmar fascia.No frank pus was found.A small rubber drain was placed in each wound and the incisions were closed with silk sutures.
Pyridoxine toxicity courtesy of your local health food store
Authors: C D Silva, D P D'Cruz
Journal: Annals of the Rheumatic Diseases (2006)

Pyridoxine or vitamin B6 is a highly water-soluble vitamin that plays an important part in the functioning of many enzymes, especially those involved in amino acid metabolism. A normal adult will require 1–2 mg of pyridoxine per day. This is adequately supplied by a normal diet. Requirements are increased in pregnancy, in malnourished patients and in patients who are taking drugs that cause a depletion of pyridoxine— for …
STROKE AND BLEEDING IN OLDER PATIENTS WITH ATRIAL FIBRILLATION TREATED WITH WARFARIN
Authors: Meytal Avgil Tsadok, Cynthia Jackevicius, Vidal Essebag, Mark Eisenberg, Elham Rahme, Karin Humphries, Jack Tu, Louise Pilote
Journal: Journal of the American College of Cardiology (2013)
Removal of a razor blade from the stomach with unusual accessory tools
Authors: K. Dolay, A. Soylu, O. Oner, E. Aygun
Journal: Endoscopy (2007)

An 18-year-old male convict was brought to the emergency department upon stating that he had swallowed a foreign body the day before. He had no complaints, and no abnormality was observed on physical examination. Direct radiography revealed a foreign body in a gastric location. On gastroduodenoscopy, a razor blade measuring 4 × 1 cm was observed at the larger curvature ([Fig. 1]). As there was no protection cap on the razor, which had sharp edges, the foreign body forceps was not used for removal. Instead, the razor blade was easily broken into pieces intragastrically using an endoscopic retrograde cholangiopancreatographic (ERCP) lithotripsy basket ([Fig. 2]), and was removed with the help of a band ligator cap connected to the endoscope ([Fig. 3]). No complication was observed. In the absence of accessory tools, an ERCP basket and band ligator cap allowed easy and safe removal of a sharp foreign body.
Practice based commissioning is delivering only “modest” results, watchdog says
Authors: Zosia Kmietowicz
Journal: BMJ (2007)

Practice based commissioning is failing to deliver the benefit for patients envisaged by the government because of a lack of incentives to get GPs on board, says the public spending watchdog.

The policy to devolve responsibility for commissioning services from primary care trusts to general practices at the local level was introduced in 2005-6 and is a main plank of the NHS reform programme. But the Audit Commission says it is suffering from poor support from primary care trusts for GPs to develop projects—including accurate information on budgets, what savings have been made, and how these savings could be used to develop other services.

“Unless you get the financial infrastructure right it [practice based commissioning] won't work,” said Andy McKeon, …
"Isolated" T-Wave Negativity in the "Ischemic Phase" of Myocardial Infarction in Man
Authors: ROBERT C. SCHLANT, HAROLD D. LEVINE, C. CABELL BAILEY
Journal: Circulation (1954)

T-wave inversion, in leads localized to a small segment of the precordium, has in rare instances been described as a normal variant. The present report concerns a number of individuals in whom more or less similar T-wave changes developed under circumstances suggesting myocardial ischemia, and who went on to develop acute infarction of the anterior wall of the heart. This may be a clinical analogue of the brief T-wave inversion which has been observed early in experimental coronary artery compression.
Alcoholism and society.
Authors: Melvin Thorner
Journal: JAMA (1963)

Few problems of western civilized behavior are so obtrusive as the question of alcoholism. The determinants as to whether or not Person A or Person B will become an alcoholic are incompletely known. The volume by Dr. Chafetz and Mr. Demone is a survey of alcoholism. In no sense does it constitute a complete explanation of alcoholism or a method of predicting in whom alcoholism may occur or a method of sure cure in those in whom it has occurred. As the authors point out, alcoholism has existed in many different sorts of societies. In some of these it has constituted a problem and in others merely a social or religious rite. In American culture of the present day, alcoholism presents a major problem. It is juvenile to dismiss this problem with the casual statement that alcohol constitutes a retreat from psychological factors. That it does this on occasion, no
Migraine with aura and the risk of increased mortality
Authors: K. Berger, S. Evers
Journal: BMJ (2010)

Any discussion of risks should be tailored to the individual

Evidence suggests that people who have migraine with aura have increased risks of cardiac and cerebrovascular disease.1 Two linked cohort studies add to this evidence. Gudmundsson and colleagues (doi:10.1136/bmj.c3966) examined whether migraine with aura in mid-life is associated with increased mortality from cardiovascular disease, other causes, and all causes,2 and Kurth and colleagues (doi:10.1136/bmj.c3659) assessed the relation between migraine with aura and haemorrhagic stroke.3

The first study followed 18 725 men and women for about 25 years.2 Because of the large number of people and the long follow-up the authors were able to analyse specific causes of death. They found that people with migraine with aura had a significantly higher risk of all cause mortality (hazard ratio 1.21, 95% confidence interval 1.12 to 1.30) and mortality from cardiovascular disease (1.27, 1.13 to 1.43), mainly as a result of coronary heart disease (1.28, 1.11 to 1.49) and stroke (1.40, 1.10 to 1.78).

In the second study, Kurth and colleagues assessed 27 860 women aged over 45 who took part in the US Women’s Health Study.3 They found an increased risk of haemorrhagic stroke in women who had migraine with aura (2.25, 1.11 to 4.54). …
Hypertension, Asymmetric Renal Parenchymal Defect, Sterile Urine, and High E. coli Antibody Titre
Authors: H. J. Andersen, B. Jacobsson, H. Larsson, J. Winberg
Journal: BMJ (1973)

During an 11-year period four children were seen with asymmetric renal parenchymal reduction, arterial hypertension, and sterile urine. The history and radio-logical or histological findings, or both, were consistent with "abacterial pyelonephritis" induced by bacterial infection in early childhood. All four had raised antibody titres to Escherichia coli. Three possibilities may explain the high antibody titres and insidious course of the renal damage-the presence of bacterial variants or amorphous bacterial antigen in the kidneys or the fact that because of cross-reactivity between certain E. coli O antigens and renal tissue the "E. coli antibodies" were, in fact, autoantibodies.
Cell surface receptor-specific scaffold requirements for adhesion to laminin-derived peptide–chitosan membranes
Authors: Kentaro Hozumi, Dai Otagiri, Yuji Yamada, Ayano Sasaki, Chikara Fujimori, Yuki Wakai, Tatsuya Uchida, Fumihiko Katagiri, Yamato Kikkawa, Motoyoshi Nomizu
Journal: Biomaterials (2010)
Urban adolescents' perceptions of health worldwide
Authors: Kristin N Mmari, Beth Marshall, Freya Sonenstein, Farah Qureshi, Chaohua Lou, Yan Cheng, Ershang Gao, Chunyan Yu, Ziliang Wang, Qiguo Lian, Rajib Acharya, Shireen Jejeebhoy, Adesola Sangowawa, Oladosu Ojengbede, Emilie Venables, Sinead Delany-Moretlwe, Heena Brambhatt
Journal: The Lancet (2012)
Durable remissions in a pivotal phase 2 study of brentuximab vedotin in relapsed or refractory Hodgkin lymphoma
Authors: Ajay K. Gopal, Robert Chen, Scott E. Smith, Stephen M. Ansell, Joseph D. Rosenblatt, Kerry J. Savage, Joseph M. Connors, Andreas Engert, Emily K. Larsen, Xuedong Chi, Eric L. Sievers, Anas Younes
Journal: Blood (2014)
The Effect of Provider Case Volume on Cancer Mortality: Systematic Review and Meta-Analysis
Authors: R. L. Gruen, V. Pitt, S. Green, A. Parkhill, D. Campbell, D. Jolley
Journal: CA A Cancer Journal for Clinicians (2009)

The authors systematically reviewed the association between provider case volume and mortality in 101 publications involving greater than 1 million patients with esophageal, gastric, hepatic, pancreatic, colon, or rectal cancer, of whom more than 70,000 died. The majority of studies addressed the relation between hospital surgical case volume and short-term perioperative mortality. Few studies addressed surgeon case volume or evaluated long-term survival outcomes. Common methodologic limitations were failure to control for potential confounders, post hoc categorization of provider volume, and unit of analysis errors. A significant volume effect was evident for the majority of gastrointestinal cancers; with each doubling of hospital case volume, the odds of perioperative death decreased by 0.1 to 0.23. The authors calculated that between 10 and 50 patients per year, depending on cancer type, needed to be moved from a "low-volume" hospital to a "high-volume" hospital to prevent 1 additional volume-associated perioperative death. Despite this, approximately one-third of all analyses did not find a significant volume effect on mortality. The heterogeneity of results from individual studies calls into question the validity of case volume as a proxy for care quality, and leads the authors to conclude that more direct quality measures and the validity of their use to inform policy should also be explored.
Abstract B24: Using a unique genetically modified ovarian cancer cell line model to identify the targets for siRNA directed therapies
Authors: Patricia N. Tonin, Celia MT Greenwood, Diane MT Provencher, Anne-Marie Mes-Masson
Journal: Clinical Cancer Research (2013)

Abstract We reported that though &amp;gt;90% of high-grade serous ovarian carcinomas (HGSC) harbor somatic TP53 mutations, cases with missense mutations have significantly longer progression free and overall survival than cases with “null” mutations, and that HGSCs defined by TP53 mutation type exhibit unique differences in their genomic landscapes. Large-scale molecular genetic analyses by The Cancer Atlas Group (TCGA) have identified numerous genes/molecular pathways that could be targeted for therapy in HGSC. A large number of candidates were reported, whereby the results were affected by heterogeneity of samples. We have analyzed the transcriptomes from a unique HGSC cell line model with altered in vivo tumorigenic and in vitro growth characteristics to understand the biology of HGSC as we have shown in previous analyses that the pathways affected intersected those found altered in tumors. We posit that investigating phenotypically defined cancer cell line models could facilitate the identification of targets for siRNA-based therapeutics (as an example). Towards this goal, we have characterized the transcriptomes (n~700 RNAs) derived from our parental HGSC cell line model and derived genetically modified cell lines. The cell line was derived from long term passage of ovarian ascites, harbors a somatic missense TP53 mutation and exhibits suppression of tumorigenicity in murine models. The genetically modified derivative cell lines have lost tumorigenic potential and exhibit altered growth characteristics. We compared their transcriptomes, derived a list a genes correlated with these alterations and then compared them to transcriptomes from public data sets: ovarian surface epithelial cells (n=10) and HGSC (n=56); and (2) TCGA samples (n~300). A defined list of known and new genes was identified by these comparative analyses pointing to targets that could be used to affect tumorigenic potential. The genetically modified model provides a new avenue of research that has the potential to elucidate pathways important in HGSC, especially those involved in tumorigenicity, as well as define targets for the development of RNA-based targeted therapeutics. Citation Format: Patricia N. Tonin, Celia MT Greenwood, Diane MT Provencher, Anne-Marie Mes-Masson. Using a unique genetically modified ovarian cancer cell line model to identify the targets for siRNA directed therapies. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr B24.