Leukocytoclastic Vasculitis After High-Dose Methotrexate
Authors: M. NAVARRO
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 September 1986Leukocytoclastic Vasculitis After High-Dose MethotrexateM. NAVARRO, M.D., R. PEDRAGOSA, M.D., A. LAFUERZA, M.D., D. RUBIO, M.D., P. HUGUET, M.D.M. NAVARRO, M.D.Search for more papers by this author, R. PEDRAGOSA, M.D.Search for more papers by this author, A. LAFUERZA, M.D.Search for more papers by this author, D. RUBIO, M.D.Search for more papers by this author, P. HUGUET, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-3-471_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Leukocytoclastic vasculitis is a rare side effect of cytostatic treatment. This lesion has been seen after treatment with busulfan, hydroxyurea, and propylthiouracil (1), but it has not been seen in association with osteogenic sarcoma. We describe the case of a patient with osteogenic sarcoma who developed a leukocytoclastic vasculitis that could be ascribed to treatment with high-dose methotrexate.A 45-year-old man developed osteogenic sarcoma in the condyle of his left femur. He was placed on a preoperative chemotherapeutic protocol using the drug schedule proposed by Rosen and colleagues (2). Briefly, this regimen consists of four weekly doses...References1. WEISS R. Hypersensitivity reaction to cancer chemotherapy. Semin Oncol. 1982;9:5-13. MedlineGoogle Scholar2. ROSENCAPARROSHUVOS GBA. Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer. 1982;49:1221-30. CrossrefMedlineGoogle Scholar3. KAPLANWIERNIK RP. Neurotoxicity of antineoplastic drugs. Semin Oncol. 1982;9:103-30. MedlineGoogle Scholar4. CADMANLUNDBERGBERTINO EWJ. Systemic methotrexate toxicity: a pharmacological study of its occurrence after intrathecal administration in a patient with renal failure. Arch Intern Med. 1976;136:1321-2. CrossrefMedlineGoogle Scholar5. LANZKOWSKYJAYABOSESHENDELEVY PSAR. Vasculitis as a complication of high-dose methotrexate in the treatment of acute leukemia [Letter]. Am J Dis Child. 1976;130:675. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. NAVARRO, M.D.; R. PEDRAGOSA, M.D.; A. LAFUERZA, M.D.; D. RUBIO, M.D.; P. HUGUET, M.D.Affiliations: Valle Hebron Hospital 08035 Barcelona Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMethotrexate-Induced Vasculitis in a Child with Systemic Onset Juvenile Idiopathic ArthritisLeukocytoclastic Vasculitis and Desensitization to High-dose Methotrexate in Primary Central Nervous System LymphomaDrug ReactionsVascular Toxicity of Antineoplastic AgentsCutaneous and Systemic Manifestations of Drug-Induced VasculitisMethotrexate-responsive chronic idiopathic urticaria: a report of two cases.Leukocytoclastic vasculitis induced by low-dose methotrexate: in vitro evidence for an immunologic mechanismCutaneous necrotizing vasculitis after low dose methotrexate therapy for rheumatoid arthritis: A possible manifestation of methotrexate hypersensitivityAcute febrile toxic reaction in patients with refractory rheumatoid arthritis who are receiving combined therapy with methotrexate and azathioprineCutaneous Lymphocytic Vasculopathy in Lymphoproliferative Disorders-A Paraneoplastic Lymphocytic Vasculitis of the SkinCutaneous drug reactionsTreatment of vasculitis.Long-term methotrexate therapy for rheumatoid arthritisDrug-induced vasculitidesRheumatic syndromes caused by antirheumatic drugsToxic Skin Reaction Restricted to Palms and Soles after High-Dose MethotrexateCUTANEOUS VASCULITIS AFTER INTERMEDIATE DOSE OF METHOTREXATE (IDMTX)Drug-Induced Rheumatic SyndromesMethotrexate in rheumatoid arthritis 1 September 1986Volume 105, Issue 3Page: 471-472KeywordsDrugsFemurLesionsMethotrexateSarcomaVasculitis ePublished: 1 December 2008 Issue Published: 1 September 1986 PDF downloadLoading ...