tbuckley/cabot-search huggingface dataset:
Use of Propranolol in a Coronary Care Unit.
Authors: Louis Lemberg
Journal: Annals of Internal Medicine (1969)

s1 May 1969Use of Propranolol in a Coronary Care Unit.Louis Lemberg, M.D., F.A.C.P., Agustin Castellanos Jr., M.D., Azucena G. Arcebal, M.D.Louis Lemberg, M.D., F.A.C.P.Search for more papers by this author, Agustin Castellanos Jr., M.D.Search for more papers by this author, Azucena G. Arcebal, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1078_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is frequently stated that beta-blocking agents are contraindicated in arrhythmias occurring during acute myocardial infarction. This is a report on 12 patients in a coronary care unit who developed supraventricular arrhythmias during the first 5 days of an acute myocardial infarction. Five had atrial fibrillation; three, atrial flutter; two, atrial tachycardia; and two, junctional tachycardia. A total of 16 episodes were treated. In all patients the ventricular rates exceeded 140/min. Intravenous propranolol was given at a rate of 0.5 mg every 2 min until sinus rhythm was established. All patients were in moderate to severe congestive heart failure, but... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Miami, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1078-1079KeywordsAcute myocardial infarctionArrhythmiaAtrial fibrillationCardiac care unitHeart failureTachycardia Issue Published: 1 May 1969 PDF DownloadLoading ...
Pharmacokinetic Analysis (PK) of Immune Globulin Subcutaneous (Human), 10% (IGSC) Administered Intravenously or Subcutaneously in Subjects with Primary Immunodeficiency Diseases (PIDD)
Authors: H. Leibl, R.L. Wasserman, I. Melamed, M. Stein, W. Engl, R.I. Schiff, D. Gelmont, W.J. Grossman
Journal: Journal of Allergy and Clinical Immunology (2011)
Looking for images of memory
Authors: Narinder Kapur
Journal: Behavioral and Brain Sciences (1995)

Abstract This is an excellent book but it lacks a detailed presentation and formulation of images of memory. Positron emission tomography (PET) findings sometimes raise more enigmatic questions than they answer, with differences between studies and differences with established lesion evidence. Perhaps the book could have been more critical in its analysis of these enigmas, covering more of the basic issues and assumptions underlying PET research.
The fast of Ramadan.
Authors: D. A. McHardy, M. Ephraim
Journal: BMJ (1992)

examination.Infants cannot describe their complaints and often resent abdominal palpation.Stringer and colleagues confirm that among children with intussusception only a minority have the traditional triad of symptoms.It is natural for trainees in general practice to try to reach an accurate diagnosis, but in these difficult
Malignancy in Kaolin Pneumoconiosis Found With F-18 FDG Positron Emission Tomography
Authors: Hadyn T. Williams, Veronica Solis, Thomas A. Dillard, James R. Gossage, Lawrence J. Freant
Journal: Clinical Nuclear Medicine (2008)

Kaolin pneumoconiosis may produce radiologic findings similar to those of malignancy. Current management includes serial radiologic examination and lung sampling of suspicious parenchymal opacities and nodules to exclude associated malignancy. This may result in unnecessary pulmonary resections in patients with already compromised lung function. In a patient with known kaolin pneumoconiosis and multiple nodules, we used positron emission tomography to identify suspicious areas for malignancy that were confirmed by open lung biopsy, leading to successful lung cancer treatment.
Fractures of the Tibial Spines
Authors: Charles H. Bradford, Ronald W. Adams, H. Kelvin Magill
Journal: New England Journal of Medicine (1949)

FRACTURES of the tibial spines, like all the less common fractures, receive so little attention in medical literature that even the specialists lose contact with the trends of treatment. It seems justified, therefore, to give this topic a thorough airing on the principle of "let sleeping dogs wake," even though our discussion may fail to contribute any vitally new ideas. The occurrence, recently, of 5 cases in our combined observation gives practical significance to such a review.In this age of radiology it is apt to be forgotten that the entire foundation of knowledge of fracture pathology was established, before . . .
Brain edema and inflammatory activation in bile duct ligated rats with diet-induced hyperammonemia: A model of hepatic encephalopathy in cirrhosis
Authors: Rodrigo Jover, Regina Rodrigo, Vicente Felipo, Ricardo Insausti, Javier Sáez-Valero, M. Salud García-Ayllón, Isabel Suárez, Asunción Candela, Antonio Compañ, Angel Esteban, Omar Cauli, Eva Ausó, Erika Rodríguez, Ana Gutiérrez, Eva Girona, Slaven Erceg, Pere Berbel, Miguel Pérez-Mateo
Journal: Hepatology (2006)

Studies of the pathogenesis of hepatic encephalopathy are hampered by the lack of a satisfactory animal model. We examined the neurological features of rats after bile duct ligation fed a hyperammonemic diet (BDL+HD). Six groups were studied: sham, sham pair-fed, hyperammonemic, bile duct ligation (BDL), BDL pair fed, and BDL+HD. The BDL+HD rats were made hyperammonemic via an ammonia-containing diet that began 2 weeks after operation. One week later, the animals were sacrificed. BDL+HD rats displayed an increased level of cerebral ammonia and neuroanatomical characteristics of hepatic encephalopathy (HE), including the presence of type II Alzheimer astrocytes. Both BDL and BDL+HD rats showed activation of the inflammatory system. BDL+HD rats showed an increased amount of brain glutamine, a decreased amount of brain myo-inositol, and a significant increase in the level of brain water. In coordination tests, BDL+HD rats showed severe impairment of motor activity and performance as opposed to BDL rats, whose results seemed only mildly affected. In conclusion, the BDL+HD rats displayed similar neuroanatomical and neurochemical characteristics to human HE in liver cirrhosis. Brain edema and inflammatory activation can be detected under these circumstances.
P85 Home and school directly observed therapy in a child with difficult and life threatening asthma
Authors: G Nyamugunduru, J Smith, V Moreton
Journal: Thorax (2013)

<h3>Background and aim</h3> We report the case of a child with difficult and life- threatening asthma whose control improved with directly observed therapy (DOT). School based DOT improves adherence<b><sup>1</sup></b> but to date there are no publications of combined home and school DOT. <h3>Case report</h3> The child was commenced on Beclomethasone aged 4 years following repeat admissions with asthma. Clinic attendance was erratic. Occasionally she arrived in clinic with wheeze and saturations in the 80’s. Health behaviour did not change despite warning parents about risk of death. A common assessment framework (CAF) was initiated. Following a life threatening asthma episode (aged 6 years) maintenance therapy was increased to Seretide 250 mcg bd (spacer) and Montelukast 5mg od. IgE was 1556 and House Dust Mite RAST positive. Clinic attendance and asthma control temporarily improved. Following another two admissions with life threatening attacks SloPhylline 250mg am/125mg pm was added. Theophyline levels were found to be &lt;2 mg/l after a further serious admission. Maintenance oral prednisolone was commenced and she was referred to tertiary hospital for consideration of Omalizumab. She was concurrently referred to Social services. At case conference she was put under a child protection plan for reasons of child neglect. DOT service at home and school was commenced. Non-attendance to clinics immediately ceased. There were no further hospital admissions. She was weaned off prednisolone. SloPhylline was reduced to 125mg bd. A lower dose of Seretide was attempted but unsuccessful. DOT was funded by Social services. The cost was £24.24 per week term- time and £37.66 per week during school holidays. <h3>Discussion</h3> Before starting regular oral prednisolone or Omalizumab in difficult paediatric asthma a trial of DOT could be worth considering. It is safer and cheaper. <h3>References</h3> Halterman JS <i>et al.</i> Randomized controlled trial to improve care for urban children with asthma: results of the School-Based Asthma Therapy trial. <i>Arch Pediatr Adolesc Med</i>. 2011 Mar;165(3):262–8. doi: 10.1001/archpediatrics.2011.1.
Wheezing Due to Pulmonary Embolism
Authors: J. R. Webster, G. B. Saadeh, P. R. Eggum, J. R. Suker
Journal: New England Journal of Medicine (1966)

SATISFACTORY management of pulmonary embolism is complicated by the fact that diagnostic cardiopulmonary symptoms and physical findings are often almost absent, evanescent or equivocal, and the source of emboli may not be evident. In most series an ante-mortem diagnosis of pulmonary embolic disease is not made in most cases, and its true incidence is consistently underestimated.1 , 2 It is therefore of value for all physicians to be aware of any clinical signs that aid in the recognition of pulmonary thromboembolism so that they may initiate proper therapy before the onset of extensive irreversible pulmonary vascular damage or a final catastrophic episode. . . .
Emergence of two populations of methicillin-resistant <i>Staphylococcus aureus</i> with distinct epidemiological, clinical and biological features, isolated from patients with community-acquired skin infections
Authors: P. Del Giudice, V. Blanc, F. Durupt, M. Bes, J-P. Martinez, E. Counillon, G. Lina, F. Vandenesch, J. Etienne
Journal: British Journal of Dermatology (2005)

Community-acquired skin and soft-tissue infections due to methicillin-resistant Staphylococcus aureus (MRSA) are an emerging clinical and epidemiological problem.To characterize community-acquired skin infections caused by S. aureus, and especially MRSA.From November 1999 to December 2003, we conducted in a French hospital a prospective epidemiological, clinical and bacteriological study of skin infections acquired in the community, applying strict criteria for true community-acquired MRSA (CA-MRSA) and health-care-associated MRSA (HCA-MRSA).One hundred and ninety-seven patients had 207 skin infections (154 primary and 53 secondary infections). Twenty-two (11%) patients had skin infections caused by MRSA. The incidence of MRSA skin infections acquired in the community rose from 4% in 2000 to 17% in 2003, but the increase was not statistically significant. Six patients (3%) were infected by CA-MRSA and 15 (8%) by HCA-MRSA; one patient was lost to follow-up and could not be classified. CA-MRSA and HCA-MRSA had different epidemiological, clinical and biological characteristics. CA-MRSA infections were more severe than HCA-MRSA infections: all the CA-MRSA infections (six of six, 100%) required surgical treatment, compared with only two (15%) of 13 with HCA-MRSA infection (P < 0.001). CA-MRSA all belonged to the same clonal strain, harbouring an agr type 3 allele and the Panton-Valentine leucocidin genes (not detected in HCA-MRSA) and possessing a specific antibiotype.Two populations of MRSA causing skin infections are emerging in the French community, with distinct epidemiological, clinical and biological characteristics.
Dopamine Restores Lung Ability to Clear Edema in Rats Exposed to Hyperoxia
Authors: FERNANDO J. SALDÍAS, EMILIA LECUONA, ALEJANDRO P. COMELLAS, KAREN M. RIDGE, JACOB I. SZNAJDER
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Exposure to hyperoxia causes lung injury, decreases active sodium transport and lung edema clearance in rats. Dopamine (DA) increases lung edema clearance by stimulating vectorial Na+ flux and Na,K-ATPase function in rat alveolar epithelium. This study was designed to test whether DA (10− 5 M) would increase lung edema clearance in rats exposed to 100% O2 for 64 h. Active Na+ transport and lung edema clearance decreased by approximately 44% in rats exposed to acute hyperoxia (p < 0.001). DA increased lung edema clearance in room air breathing rats (from 0.50 ± 0.02 to 0.75 ± 0.06 ml/h) and in rats exposed to 100% O2 (from 0.28 ± 0.03 to 0.67 ± 0.03 ml/h). Disruption of cell microtubular transport system by colchicine blocked the stimulatory effect of DA on active Na+ transport in control and hyperoxic rats, whereas the isomer β -lumicolchicine, which does not affect cell microtubular transport, did not inhibit the stimulatory effects of dopamine. The Na,K-ATPase α1-subunit protein abundance increased in the basolateral membranes of alveolar type II (ATII) cells incubated with 10− 5 M DA for 15 min, probably by recruiting Na+ pumps from intracellular pools. Colchicine, but not β -lumicolchicine, prevented the recruitment of α1 subunits to the plasma membrane by DA. Accordingly, DA restored lung ability to clear edema in hyperoxic-injured rat lungs. Conceivably, dopamine induces recruitment of Na+ pumps from intracellular pools to the plasma membrane of alveolar epithelial cells and thus increases lung edema clearance.
Reviews and Notes: Cardiology: Atlas of Heart Diseases. Vol. 6: Heart Disease in the Presence of Disorders of Other Organ Systems
Authors: Joshua Wynne
Journal: Annals of Internal Medicine (1996)

Literature of Medicine15 September 1996Reviews and Notes: Cardiology: Atlas of Heart Diseases. Vol. 6: Heart Disease in the Presence of Disorders of Other Organ SystemsJoshua Wynne, MDJoshua Wynne, MDWayne State University, Detroit, MI 48201Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-6-199609150-00055 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail MH Crawford and E Braunwald; eds. 264 pages. St. Louis: Mosby; 1996. $125.00. ISBN 1878132288. Order phone 800-426-4545.As the utility and availability of computer-based informatics increase, the role of textbooks is becoming ambiguous; they currently serve as a bridge between the printed media of the past and the cyberspace future. This is particularly true of atlases such as this one, which are particularly well suited for computer-based multimedia presentations.This attractive volume is the sixth in a series of 13 atlases that deal with a wide spectrum of cardiovascular diseases, from hypertension to valvular and congenital heart disease. The ... Author, Article, and Disclosure InformationAffiliations: Wayne State University, Detroit, MI 48201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1996Volume 125, Issue 6Page: 528KeywordsCardiovascular therapyComputersCongenital heart diseaseElectrocardiographyEmotionsForecastingHypertensionInternetLibrariesSystemic diseases ePublished: 15 August 2000 Issue Published: 15 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid
Authors: M Andreeff, S Jiang, X Zhang, M Konopleva, Z Estrov, VE Snell, Z Xie, MF Okcu, G Sanchez-Williams, J Dong, EH Estey, RC Champlin, SM Kornblau, JC Reed, S Zhao
Journal: Leukemia (1999)
Renal Transplantation for Childhood Cystinosis
Authors: C. Patrick Mahoney, Gary E. Striker, Robert O. Hickman, Gilbert B. Manning, Thomas L. Marchioro
Journal: New England Journal of Medicine (1970)

Four cystinotic children with renal failure received a renal allograft from a parent. The follow-up durations for the four patients were eight, 14, 16 and 32 months; final creatinine clearances were 115, 66, 130 and 41 ml per minute per 1.73 m2 respectively. No decrease in cystine crystals was visible on corneal and bone-marrow examinations. Although the allografts accumulated intracellular cystine, the distribution of cystine was different from that in the natural disease. Cystine crystals were plentiful in interstitial cells of both the patients' original and their transplanted kidneys, but crystals were found in glomerular and tubular epithelial cells only in the original kidneys. Moreover, changes in renal function correlated with complications of transplantation and clinical rejection episodes rather than with the amount of accumulated cystine. So far the Fanconi syndrome does not appear to be developing, and all patients have returned to full activity.
Significant mobilization of both conventional and regulatory T cells with AMD3100
Authors: Leslie S. Kean, Sharon Sen, Olusegun Onabajo, Karnail Singh, Jennifer Robertson, Linda Stempora, Aylin C. Bonifacino, Mark E. Metzger, Daniel E. L. Promislow, Joseph J. Mattapallil, Robert E. Donahue
Journal: Blood (2011)
A "Liddle" Aspersion
Authors: L. M. Fredric
Journal: JAMA (1966)

<h3>To the Editor:—</h3> In reference to Dr. G. G. Liddle's Letter to the Editor (<b>195</b>:1157, 1966), I would like to proclaim: Who climbs the Grammar-Tree, distinctly knows Where Noun, and Verb, and Participle grows. Juvenal, Satires True, "use" is a noun or a verb. But, as Juvenal points out, "use" also has a participial form, or verbal adjective, "using." In each of the examples cited, "using" is just that; however, in each case, the verbal adjective modifies an incorrect noun. The results did not use a scintillation camera, any more than did the dogs use a 20-gauge needle. Perhaps Dr. Liddle might agree with the dramatist Sheridan when he said, "An aspersion upon my parts of speech!"—but it is only a grammatical aspersion which, as anyone knows, is the very mildest kind.
Differential impact of allelic ratio and insertion site in FLT3-ITD–positive AML with respect to allogeneic transplantation
Authors: Richard F. Schlenk, Sabine Kayser, Lars Bullinger, Guido Kobbe, Jochen Casper, Mark Ringhoffer, Gerhard Held, Peter Brossart, Michael Lübbert, Helmut R. Salih, Thomas Kindler, Heinz A. Horst, Gerald Wulf, David Nachbaur, Katharina Götze, Alexander Lamparter, Peter Paschka, Verena I. Gaidzik, Veronica Teleanu, Daniela Späth, Axel Benner, Jürgen Krauter, Arnold Ganser, Hartmut Döhner, Konstanze Döhner
Journal: Blood (2014)
Systemic tobramycin concentrations during selective decontamination of the digestive tract in intensive care unit patients on continuous venovenous hemofiltration
Authors: Meriel Mol, Hendrikus J. M. van Kan, Marcus J. Schultz, Evert de Jonge
Journal: Intensive Care Medicine (2008)

To study whether selective decontamination of the digestive tract (SDD) results in detectable serum tobramycin concentrations in intensive care unit (ICU) patients with acute renal failure treated with continuous venovenous hemofiltration (CVVH).Prospective, observational, single-center study in a mixed medical-surgical ICU.Adult ICU patients receiving SDD for at least 3 days and being treated with CVVH because of acute renal failure.Tobramycin serum concentrations were measured at the 3rd day after start of CVVH and every 3 days thereafter. Detectable serum concentrations of tobramycin were found in 12 (63%) of 19 patients and in 15 (58%) of the 26 samples. With a toxic tobramycin concentration defined as more than 2.0 mg/l, we found one patient with a toxic concentration of 3.0 mg/l. In three other patients tobramycin concentrations of >or=1.0 mg/l were found.In patients with acute renal failure treated with CVVH, administration of SDD with tobramycin can lead to detectable and potentially toxic serum tobramycin concentrations.
Short-term feedback regulation of bile salt uptake by bile salts in rodent liver
Authors: Stefanie Mühlfeld, Olga Domanova, Thomas Berlage, Claudia Stross, Angelika Helmer, Verena Keitel, Dieter Häussinger, Ralf Kubitz
Journal: Hepatology (2012)

The sodium taurocholate cotransporting polypeptide (Ntcp) is the major bile salt uptake transporter at the sinusoidal membrane of hepatocytes. Short-term feedback regulation of Ntcp by primary bile salts has not yet been investigated in vivo. Subcellular localization of Ntcp was analyzed in Ntcp-transfected HepG2-cells by flow cytometry and in immunofluorescence images from tissue sections by a new automated image analysis method. Net bile salt uptake was investigated in perfused rat liver by a pulse chase technique. In Flag-Ntcp-EGFP (enhanced green fluorescent protein) expressing HepG2-cells, taurochenodeoxycholate (TCDC), but not taurocholate (TC), induced endocytosis of Ntcp. TCDC, but not TC, caused significant internalization of Ntcp in perfused rat livers, as shown by an increase in intracellular Ntcp immunoreactivity, whereas Bsep distribution remained unchanged. These results correlate with functional studies. Rat livers were continuously perfused with 100 μmol/L of TC. 25 μmol/L of TCDC, taurodeoxycholate (TDC), tauroursodeoxycholate (TUDC), or TC were added for 30 minutes, washed out, followed by a pulse of (3) [H]-TC. TCDC, but not TDC, TUDC, or TC significantly increased the amount of (3) [H]-TC in the effluent, indicating a reduced sinusoidal net TC uptake. This effect was sensitive to chelerythrine (protein kinase C inhibitor) and cypermethrin (protein phosphatase 2B inhibitor). Phosphoinositide 3-kinase (PI3K) inhibitors had an additive effect, whereas Erk1/2 (extracellular signal activated kinase 1/2), p38MAPK, protein phosphatase 1/2A (PP1/2A), and reactive oxygen species (ROS) were not involved.TCDC regulates bile salt transport at the sinusoidal membrane by protein kinase C- and protein phosphatase 2B-mediated retrieval of Ntcp from the plasma membrane. During increased portal bile salt load this mechanism may adjust bile salt uptake along the acinus and protect periportal hepatocytes from harmful bile salt concentrations.
Cryptogenic fibrosing alveolitis: lack of association with Epstein-Barr virus infection.
Authors: A Wangoo, R J Shaw, T C Diss, P J Farrell, R M du Bois, A G Nicholson
Journal: Thorax (1997)

Cryptogenic fibrosing alveolitis (CFA) is a well defined clinical entity of unknown aetiology. An association between CFA and the presence of protein indicating Epstein-Barr virus (EBV) replication within epithelial cells of the respiratory tract has recently been suggested, leading to speculation for a role for EBV in the pathogenesis of CFA.Lung tissue was obtained from patients in three groups: those with cryptogenic fibrosing alveolitis, either lone or associated with systemic sclerosis; patients with other pulmonary disorders; and patients with normal lung. Paraffin blocks were stained using three antibodies raised against well defined EBV antigens. In addition, EBER-1 and EBER-2 anti-sense nucleotide probes were used in an attempt to identify EBV RNA. DNA was also extracted from the tissue sections and evaluated for evidence of EBV DNA using the polymerase chain reaction.Immunohistochemistry showed inconsistent focal positive staining with anti-EBV antibodies in all three groups, but there was no evidence of EBV RNA using in situ hybridisation. None of the samples from patients with pulmonary fibrotic disorders was found to contain EBV DNA following gene amplification.Contrary to an earlier report, these results do not support the hypothesis that EBV has a role in the pathogenesis of CFA.