tbuckley/cabot-search huggingface dataset:
Inhibition of uptake of transferrin-bound iron by human hepatoma cells by nontransferrin-bound iron
Authors: D Trinder
Journal: Hepatology (1997)

The liver acquires iron from transferrin by transferrin receptor-mediated (TR) and transferrin receptor-independent pathways (NTR) and from nontransferrin-bound iron (NTB-Fe). Iron uptake by the NTR processes involves an iron-carrier mediated step. Experiments, using human hepatoma cells (HuH7) transfected with TR antisense (sense for control) RNA expression vectors to suppress TR expression, were performed to examine the effect of unlabeled NTB-Fe as iron citrate on the uptake of 59Fe-125I-transferrin. This was to determine if the uptake of transferrin-bound iron (Tf-Fe) and NTB-Fe uptake is mediated by a common iron-carrier. Iron citrate inhibited the uptake of 59Fe-transferrin (2.5 micromol/L Fe) in a concentration-dependent manner with a maximum effect when the citrate-iron:Tf-Fe molar ratio was 10:1. Transferrin uptake was not affected. At a lower Tf-Fe concentration of (0.125 micromol/L) when uptake of iron is TR-mediated, a 10-fold molar excess of iron citrate had no effect on Tf-Fe uptake by HuH7 TR antisense and sense cells. However, at a higher Tf-Fe concentration (2.5 micromol/L), when uptake occurs mainly by the NTR-mediated process, there was a 40% reduction in the membrane-bound and intracellular uptake of iron. Iron citrate did not affect the maximum rate (Vmax) of Tf-Fe uptake but the Michaelis-Menten constant (Km) for Tf-Fe uptake by the NTR-mediated process was increased, indicating there was competitive inhibition of Tf-Fe uptake by iron citrate. These results suggest that the uptake of NTB-Fe and Tf-Fe by the NTR-mediated process occurs by the same cellular pathway, using a common iron-carrier.
Epidemiology of adult Still's disease.
Authors: C A Dunne, J Davies
Journal: Annals of the Rheumatic Diseases (1996)

<h3>Abstract</h3> The Wartberg culture (WBC, 3,500-2,800 BCE) dates to the Late Neolithic period, a time of important demographic and cultural transformations in western Europe. We perform a genome-wide analysis of 42 individuals who were interred in a WBC collective burial in Niedertiefenbach, Germany (3,300-3,200 cal. BCE). Our results highlight that the Niedertiefenbach population indeed emerged at the beginning of the WBC. This farming community was genetically heterogeneous and carried a surprisingly large hunter-gatherer ancestry component (40%). We detect considerable differences in the human leukocyte antigen gene pool between contemporary Europeans and the Niedertiefenbach individuals whose immune response was primarily geared towards defending viral infections.
Authors, Readers, and Editors—A Postscript
Authors: A. GORMAN HILLS
Journal: Annals of Internal Medicine (1964)

Brief Communication1 January 1964Authors, Readers, and Editors—A PostscriptA. GORMAN HILLS, M.D.A. GORMAN HILLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-1-158 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA recent editorial (1) in the ANNALS OFINTERNALMEDICINEaddressed itself with penetration and charm to some of the all-too-human failings on both sides which contribute to disharmony between writer and editor. Authors who have dealings with a variety of medical journals must nevertheless regret that one of their sorest complaints was not brought into focus. I mean the fact and circumstances of routine and extensive recasting of their articles by editorial assistants intoxicated with the virtues of standardized restyling. This practice—mercifully not yet universal, though spreading with great rapidity—is sufficiently disquieting that editors must surely examine their consciences...References1. ELKINTON JR: Authors, readers, and editors—dreams of medical writing. Ann. Intern. Med. 59: 410, 1963. LinkGoogle Scholar2. FLESCH R: The Art of Readable Writing, Harper and Bros., New York, 1949; Collier Books, New York, 1962. Google Scholar3. FOWLERFOWLER HFFG: The King's English, 3rd edition, Oxford Press, Oxford, 1931, page 262. "Such was the view," they continue, "with which, on a matter of even greater importance than punctuation, Procrustes identified himself; but he came to a bad end." Google Scholar4. WHYTE WH: The Organization Man, Simon and Schuster, New York, 1956. Google Scholar5. BARZUN J: The House of Intellect, Harper and Brothers, New York, 1959. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1964Volume 60, Issue 1Page: 158-159KeywordsEmotions Issue Published: 1 January 1964 PDF DownloadLoading ...
CT radiation risks coming into clearer focus
Authors: A. Sodickson
Journal: BMJ (2013)

As we gather more direct evidence of the dose-response curve from childhood CT

Recent attention to the cancer risks of ionizing radiation has prompted vigorous debate about how to quantify the risks of diagnostic imaging, and whether or how these risks ought to be incorporated into our decision making process as we participate in patient care.

In the past, models of the carcinogenic risks of ionizing radiation have primarily relied on long term surveillance of the Japanese atomic bomb survivors, which showed significant increases in the incidence of cancer after effective doses greater than about 50 mSv.1 2 The relative paucity of direct data in the lower dose range delivered by diagnostic imaging has led to conflicting opinions about the shape and slope of the radiation dose-response curve.

In a linked study (doi:10.1136/bmj.f2360), Mathews and colleagues present compelling data on the magnitude of the cancer risk attributable to ionizing radiation.3 This well designed study examined a cohort of nearly 11 million young patients in the Australian national Medicare system and compared subsequent incidence of cancer in the 680 000 patients exposed to …
BALLOON OCCLUSION TEST OVERESTIMATES THE RISK OF ACUTE PULMONARY CONGESTION AFTER THE TRANSCATHETER CLOSURE OF ATRIAL SEPTAL DEFECT IN ADULTS
Authors: Koji Nakagawa, Yasufumi Kijima, Kengo Kusano, Hiroshi Ito, Teiji Akagi
Journal: Journal of the American College of Cardiology (2012)
Italian surgeon is sentenced for carrying out bogus operations for profit
Authors: M. Day
Journal: BMJ (2010)

An Italian surgeon who removed a woman’s breast for the sole purpose of boosting his income has been sentenced to 15 years in jail by a court in Milan.

Pier Paolo Brega Massone, formerly the chief thoracic surgeon at the city’s Santa Rita clinic, was found guilty on Thursday 28 October of putting dozens of other patients under the knife needlessly at the institution, dubbed the “clinic of horrors” by the Italian press.

At least five patients died after bogus operations at the hands of the surgeon or his colleagues, prosecutors said. The court heard that more than 80 unnecessary operations, many on very sick and elderly patients, …
THE RELATION OF CHILDHOOD BEHAVIOR PROBLEMS TO ADULT PSYCHIATRIC STATUS: A 30-YEAR FOLLOW-UP STUDY OF 150 SUBJECTS
Authors: PATRICIA O'NEAL, LEE N. ROBINS
Journal: American Journal of Psychiatry (1958)

1. A preliminary report of the first 150 interviewed subjects in a long-term (30-year) follow-up study has been presented. This report emphasizes the adult psychiatric diagnoses and their relation to childhood problems. 2. Patients referred to a child guidance clinic 30 years ago were found to have a high rate of psychiatric disease as adults as compared with a matched group of normal controls. They differed little from the normal controls in their rate of neurotic reactions but presented many cases of sociopathic personalities, psychotic reactions, and alcoholism. 3. The patients who contributed primarily to the diagnosis of sociopathic personality were those who had been juvenile delinquents as children. Many of those who were psychotic as adults had a history of anti-social behavior in childhood without court hearings. Patients who were psychiatrically well as adults came mainly from the group with neurotic problems as children. The relations between the specific presenting problem and the adult psychiatric disease show that the well group was characterized by problems such as fighting, sex problems, tantrums, and the classic neurotic traits of childhood. 4. While children with neurotic problems came from families of better socio-economic background than children with anti-social problems and delinquency, class background was not found to account for the greater proportion of psychiatrically well as adults among the subjects who had had neurotic problems in childhood. 5. While patients had a higher rate of broken homes than controls, broken homes were not found to be related to the continuance of psychiatric problems into adult life. 6. Although the rate of psychiatric disease is very high in the patient group, very few of them have sought any psychiatric help.
The Solitary Pulmonary Nodule
Authors: David Ost, Alan M. Fein, Steven H. Feinsilver
Journal: New England Journal of Medicine (2003)

A 60-year-old man undergoes chest radiography during an evaluation for pneumonia, and a 1.5-cm nodule is discovered. He is a heavy smoker but has no history of lung disease. The results of a physical examination are unremarkable. How should he be evaluated?
Pancreas Divisum and Pancreatitis: a Coincidental Association?
Authors: P. Burtin, B. Person, J. Charneau, J. Boyer
Journal: Endoscopy (1991)

The aim of the present study is to assess the frequency of pancreas divisum and the features of patients with pancreas divisum in order to assess the role of this anomaly in the occurrence of pancreatitis. A total of 1049 endoscopic retrograde pancreatographics were studied between 1978 and 1988. Patients with pancreas divisum were studied in terms of their clinical findings and their disease (pancreatitis or not). Pancreas divisum was diagnosed in 62 patients (5.9 %). No statistical differences with regard to age and sex were found between patients with and without pancreas divisum. The frequency of pancreas divisum was similar in the different groups of disease, especially chronic pancreatitis, acute pancreatitis, recurrent pancreatitis and idiopathic pancreatitis. The study of pancreatograms showed that dorsal ductal abnormalities alone were found as frequently as ventral alterations alone. Our results show that pancreas divisum cannot be directly implicated in the occurrence of pancreatitis, and should not prompt a systematic sphincterotomy of the accessory papilla. This treatment should only be considered in the rare cases of acute recurrent idiopathic pancreatitis with dorsal ductal dilatation and stenosis of the accessory papilla.
Points: Regular prescribing in a residential home for elderly women
Authors: J. Stirrat
Journal: BMJ (1982)

A Ledermann and colleagues (12 June, p 1784) reporting thrombocytopenia following benoxaprofen therapy.They state that thrombocytopenia associated with benoxaprofen has not been reported before.We reported thrombocytopenia in association with leucopenia and toxic epidermal necrolysis in a 62- year-old woman after only nine days' treatment with benoxaprofen, and this was published in May 1982.
Relationship between Induced Spherical Aberration and Depth of Focus after Hyperopic LASIK in Presbyopic Patients
Authors: Benjamin Leray, Myriam Cassagne, Vincent Soler, Eloy A. Villegas, Claire Triozon, Guillermo M. Perez, Jonathan Letsch, Eric Chapotot, Pablo Artal, François Malecaze
Journal: Ophthalmology (2014)
Causal link between vitamin D deficiency and ill health still possible
Authors: B. J. Boucher
Journal: BMJ (2014)

The two BMJ articles suggest that vitamin D supplementation has limited benefits.1 2 However, their findings could be compromised by non-adjustment for several factors—inclusion of the same study data in several meta-analyses reviewed; benefits only at higher intakes (fracture reduction in older women) or with baseline deficiency (muscle strength); “thresholds” for detectable benefits (insulin resistance when final 25 hydroxyvitamin D ≥80 nmol/L); and non-exclusion …
Quantitative analysis of Malassezia in the scale of patients with psoriasis using a real-time polymerase chain reaction assay
Authors: Y. Takahata, T. Sugita, M. Hiruma, M. Muto
Journal: British Journal of Dermatology (2007)

Journal Article Quantitative analysis of Malassezia in the scale of patients with psoriasis using a real‐time polymerase chain reaction assay Get access Y. Takahata, Y. Takahata Department of Dermatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JapanDepartment of Microbiology, Meiji Pharmaceutical University, 2‐522‐1 Noshio, Kiyose, Tokyo 204‐8588, JapanDepartment of Dermatology and Allergology, Juntendo University Nerima Hospital, Nerima‐ku, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Sugita, T. Sugita Department of Microbiology, Meiji Pharmaceutical University, 2‐522‐1 Noshio, Kiyose, Tokyo 204‐8588, Japan Correspondence: Takashi Sugita. E‐mail: sugita@my‐pharm.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Hiruma, M. Hiruma Department of Dermatology and Allergology, Juntendo University Nerima Hospital, Nerima‐ku, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Muto M. Muto Department of Dermatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 4, 1 October 2007, Pages 670–673, https://doi.org/10.1111/j.1365-2133.2007.08090.x Published: 01 October 2007
Secretion of Dopa in Phaeochromocytoma
Authors: W. J. Louis, A. E. Doyle, W. C. Heath, M. J. Robinson
Journal: BMJ (1972)

In a series of 11 cases with phaeochromocytoma, two patients were found in whom the tumour secreted dopa in addition to dopamine, noradrenaline, and adrenaline. These two patients were normotensive in spite of high plasma and urinary levels of noradrenaline and adrenaline. This raises the possibility that dopa may be able to protect against the hypertensive action of noradrenaline. Such a mechanism would also explain the absence of hypertension in many cases of neuroblastoma.
The Radioiodinated Rose Bengal Test in the Diagnosis of Congenital Biliary Tract Disease
Authors: J R POLEY, C W SMITH
Journal: Clinical Nuclear Medicine (1976)

The use of the radioiodinated rose bengal (IRB) test for the diagnosis of congenital biliary tract disease (obstructive cholangiopathy) has been reviewed. Experience gained in a series of studies demonstrated that a greater diagnostic accuracy is achieved with the IRB excretion test, as compared with scintillation counting or hepatic scintigraphy. Recently introduced modifications of the IRB excretion test employing the use of either phenobarbital or cholestyramine seem of additional help in identifying the patient with biliary atresia.
A 72 old woman with a painful leg after a fall
Authors: K. C. Eseonu, M. Rafferty, S. Al-Nammari
Journal: BMJ (2015)

A 72 year old woman presented to the emergency department after tripping over uneven carpet at home. She had pain in her right groin and was unable to weight bear but had no other injuries. The fall had been a true mechanical one, with no preceding dizziness, chest pain, or palpitations. Her medical history included hypertension, and she had undergone a left (contralateral) total hip replacement four years earlier. Her only regular drug was ramipril. She lived alone, was independent in activities of daily living, and could walk short distances in the community unsupported. She had no ophthalmological disease or other visual impairment. 

On examination, her right leg was shortened and externally rotated. She could not straight raise the leg and any attempted movement was painful. Figure 1⇓ shows an anteroposterior radiograph of her right hip.





### 1. On the basis of the history, what is the most likely diagnosis?

#### Short answer

The most likely diagnosis is a proximal femoral fracture.

#### Long answer

The most likely diagnosis is a fracture of the proximal femur. Radiographic assessment is needed to differentiate between a fracture of the femoral neck or one of the proximal femoral diaphysis, and if located at the neck of the femur, to differentiate between intracapsular and extracapsular fractures. Differential diagnoses include fracture of the pubic rami, pelvic fracture, other fractures of the lower limb and axial skeleton, and soft tissue injury. Anterior dislocation of the hip would also present with an externally rotated (but abducted) limb; however, this is more commonly associated with high energy trauma such as a fall from a height or a road …
18F-DOPA PET/CT But Not 68Ga-DOTA-TOC PET/CT Revealed the Underlying Cause of Ectopic Cushing Syndrome
Authors: Camilla Schalin-Jäntti, Aapo Ahonen, Marko Seppänen
Journal: Clinical Nuclear Medicine (2012)

18F-DOPA PET/CT but not 68Ga-DOTA-TOC PET/CT revealed the cause of ectopic Cushing syndrome in a 61-year-old man. The patient presented with rapid weight gain, swollen legs, and sleep disturbances. Plasma potassium level was 2.7 mM (reference range, 3.3–4.9 mM), 24-hour urinary cortisol level was 13,124 nmol (reference range, 30–144 nmol), and plasma adrenocorticotropin level was 61 ng/L (reference range, <48 g/L). CT demonstrated prominent lymph nodes in the left lung hilus and hyperplastic adrenals but no primary tumor. 68Ga-DOTA-TOC PET/CT, which is recommended as the first-line PET imaging, was performed, but it was not diagnostic. Imaging with 18F-DOPA PET/CT revealed the underlying cause.
A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials
Authors: C M Lucas, L Wang, G M Austin, K Knight, S J Watmough, K H Shwe, R Dasgupta, Nauman M Butt, D Galvani, C F Hoyle, J R C Seale, R E Clark
Journal: Leukemia (2008)
Bradykinin B1 receptor gene polymorphism is associated with impaired coronary reactivity in women: a report from the NHLBI WISE study
Authors: Zachary Brown, Richard A. Kerensky, Susan P. McGorray, Dennis M. McNamara, Steven E. Reis, C.Noel Bairey Merz, George Sopko, Carl J. Pepine, Daniel F. Pauly
Journal: Journal of the American College of Cardiology (2002)
SOME MORE TRICHO CASES
Authors: Erich Brockelmann
Journal: JAMA (1930)

To the Editor:  —To your list of published cases—victims of the Tricho System—I wish to add yet another:  Miss M. W.  —Patient, aged 28, reported that she had had x-ray treatments at the Tricho Institute somewhat over two years ago for epilation of the hair on both arms. These treatments were given her at two-week intervals. After the sixth one patient noticed both swelling and pain in right forearm, which, however, shortly disappeared. Following this, and for this reason, she discontinued treatment. Some two years later a skin condition appeared, which grew steadily worse. At time of consultation patient exhibited multiple marked telangiectases of both forearms and lower portions of the arms. The lesions varied in size from that of a pinpoint to that of a small bean, not elevated above the surrounding skin, disappearing completely on pressure again to reappear after pressure was released. Dendritic ramifications were so numerous
Letter: Ideal diet.
Authors: J I Mann
Journal: BMJ (1973)

Melatonin and its analog 5-MCA-NAT (5-methylcarboxyamino-<i>N</i>-acetyl tryptamine) are active compounds reducing intraocular pressure (IOP). This action is mediated through MT<sub>2</sub> and the putative MT<sub>3</sub> melatonin receptor, producing a transient reduction of IOP that lasts for a few hours and has not yet been characterized. The use of melatonin and its analog are causing a decrease in chloride efflux from rabbit nonpigmented epithelial cells (NPE), possibly explaining the decrease in IOP. Melatonin and 5-MCA-NAT inhibited rabbit NPE chloride release in a concentration-dependent manner, whereas the pD<sub>2</sub> values were between 4.5 ± 1.2 and 4.4 ± 1.0, respectively. Melatonin hypotensive action was enhanced by the presence of MT<sub>2</sub> antagonists, such as DH97 (<i>N</i>-pentanoyl-2-benzyltryptamine) and 4-P-P-DOT (4-phenyl-2-propionamidotetralin) and by the nonselective melatonin receptor antagonist luzindole. Prazosin (1.5 <i>µ</i>M) partially reverses the melatonin action by acting as a selective MT<sub>3</sub> antagonist. However, at 15 nM it acts as an <i>α</i>-adrenergic receptor antagonist, enhancing the melatonin effect. Regarding the intracellular pathways triggered by melatonin receptors, neither phospholipase C/protein kinase C pathway nor the canonical reduction of intracellular cAMP was responsible for melatonin or 5-MCA-NAT actions. On the contrary, the application of these substances produced a concentration-dependent increase of cAMP, with pD<sub>2</sub> values of 4.6 ± 0.2 and 4.9 ± 0.7 for melatonin and 5-MCA-NAT, respectively. In summary, melatonin reduces the release of chloride concomitantly to cAMP generation. The reduction of Cl<sup>−</sup> secretion accounts for a decrease in the water outflow and therefore a decrease in aqueous humor production. This could be one of the main mechanisms responsible for the reduction of IOP after application of melatonin and 5-MCA-NAT.
Who is responsible for do not resuscitate status in patients with broken hips?
Authors: Rahij Anwar, Azeem Ahmed
Journal: BMJ (2007)

Hip fractures are on the rise in the ageing population of our country. It has been estimated that about 30-40% of these patients die within the first year. Although actual perioperative causes of mortality are difficult to ascertain, it is generally believed that a vast majority of early deaths occur due to medical conditions such as chest infection and fluid and electrolyte imbalance. Better outcomes have been reported in centres where the management of these patients is carried out jointly under the medical and orthopaedic teams. However, lack of resources, poor co-ordination between the orthopaedic surgeons and medical teams, and ever increasing patient load often affect the quality of treatment that these frail patients deserve. 

When elderly patients with hip fractures become acutely unwell during the perioperative care and …