The Sweet Syndrome or G-CSF Reaction?
Authors: Debra Lynn Karp
Journal: Annals of Internal Medicine (1992)

Letters15 November 1992The Sweet Syndrome or G-CSF Reaction?Debra Lynn Karp, MDDebra Lynn Karp, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-10-875_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Park and colleagues (1) describe the development of the Sweet syndrome in a woman receiving chemotherapy for breast cancer during treatment with subcutaneous granulocyte colony-stimulating factor (G-CSF).The authors largely base their diagnosis on a skin biopsy that showed a dermal neutrophilic infiltrate. They attribute the Sweet syndrome to treatment with G-CSF because the patient did not require corticosteroids and because the eruption resolved with termination of the G-CSF treatment.The Sweet syndrome is characterized histologically by a dense dermal and perivascular infiltrate composed largely of neutrophils without evidence of vasculitis (2). Granulocyte colony-stimulating factor, a hematopoietic...References1. Park J, Mehrotra B, Barnett B, Baron A, and Venook A. The Sweet syndrome during therapy with granulocyte colony-stimulating factor. Ann Intern Med. 1992;116:996-8. LinkGoogle Scholar2. Lever W and Schaumburg-Lever G. Histopathology of the Skin. Philadelphia: J.B. Lippincott Company; 1990:196. Google Scholar3. Horn T, Burke P, Karp J, and Hood A. Intravenous administration of recombinant human granulocyte-macrophage colony-stimulating factor causes a cutaneous eruption. Arch Dermatol. 1991;127:49-52. CrossrefMedlineGoogle Scholar1. Park J, Mehrotra B, Barnett B, Baron A, and Venook A. The Sweet syndrome during therapy with granulocyte colony-stimulating factor. Ann Intern Med. 1992;116:996-8. LinkGoogle Scholar2. Horn T, Burke P, Karp J, and Hood A. Intravenous administration of recombinant human granulocyte-macrophage colony-stimulating factor causes a cutaneous eruption. Arch Dermatol. 1991;127:49-52. CrossrefMedlineGoogle Scholar3. Sweet R. An acute febrile neutrophilic dermatosis. Br J Dermatol. 1864;76:349-56. CrossrefGoogle Scholar4. Kemmett D and Hunter J. Sweet's syndrome: a clinicopathologic review of twenty-nine cases. J Am Acad Dermaol. 1990;12:503-7. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Debra Lynn Karp, MDAffiliations: Johns Hopkins Hospital Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySweet Syndrome: A Review and UpdateSweet Syndrome: A Review and UpdateDrug ReactionsSWEET'S SYNDROMESweet's syndrome (acute febrile neutrophilic dermatosis)Acute neutrophilic dermatosis with myeloblastic infiltrate in a leukemia patient receiving all-trans-retnoic acid therapyBlood, blood components, plasma and plasma products 15 November 1992Volume 117, Issue 10 Page: 875-876 Keywords Biopsy Breast cancer Cancer chemotherapy Cancer treatment Chemotherapy Granulocyte colony stimulating factor Neutrophils Vasculitis ePublished: 1 December 2008 Issue Published: 15 November 1992 PDF downloadLoading ...