tbuckley/cabot-search huggingface dataset:
Migratory pulmonary infiltrates in a patient treated with sotalol
Authors: L Portel, G Hilbert, D Gruson, G Gbikpi-Benissan, JP Cardinaud
Journal: European Respiratory Journal (1998)

Migratory pulmonary infiltrates in a patient treated with sotalolTo the Editors:We read with interest the case study by FALLER et al. [1] concerning migratory pulmonary infiltrates in a patient treated with sotalol.The authors concluded that β-blockers produce an adverse effect, but we have good reason to think that the diagnosis can be refined.In particular, the patient could have been suffering from an underlying disease, such as a drug-induced lupus, and this point did not appear to have been discussed.First, the patient was female, and this is an epidemiological argument for exposure to systemic lupus erythematosus (SLE), even though this predominance is less marked in the case of induced lupus.The clinical presentation included nonspecific signs of SLE: slight fever, systemic hypertension and, in particular, a more specific sign, Raynaud's phenomenon, that should not be neglected.The patient was treated with β-blockers, which are known to provoke induced lupus [2, 3].These are often pauci-symptomatic and benign forms of SLE and do not fit the American Rheumatism Association (ARA) criteria of SLE.Secondly, immunological investigations did not contain a dosage of soluble antinuclear factors and, in particular, antihistone antibodies.The latter have a good sensitivity in these cases of induced lupus, and their absence may have diverted the suspicion of an induced lupus.Furthermore, even if seric antinuclear antibodies were absent here, as is commonly observed, one could perform antibody immunodetection on the lung biopsy with the same aim.Thirdly, although specific pulmonary involvements of SLE are rare compared to infectious manifestations, there have been several observations of bronchiolitis obliterans organizing pneumonia (BOOP) accompanying a lupus [4][5][6][7] since the first description by MATTAY et al. [8] in 1974, and this would not be an isolated report.Finally, the authors did not mention the evolution of the Raynaud's syndrome after the discontinuation of treatment; it would be interesting to know the course of all of the clinical symptoms, particularly this uncommon symptom, after the resolution of BOOP.For all of these reasons, we believe that this BOOP was not an adverse effect of the β-blocker treatment, but appeared as a manifestation of an induced lupus.This case report may represent more accurately the first case of a bronchiolitis obliterans organizing pneumonia in the course of a drug-induced lupus in a patient treated with sotalol.
THE EFFECT OF OSMIUM FIXATION ON THE HISTOLOGICAL APPEARANCE OF THE NORMAL EPIDERMAL HORNY LAYERS OF MAN AND THE GUINEA-PIG
Authors: R. I. C. SPEARMAN, P. A. RILEY
Journal: British Journal of Dermatology (1967)

Journal Article THE EFFECT OF OSMIUM FIXATION ON THE HISTOLOGICAL APPEARANCE OF THE NORMAL EPIDERMAL HORNY LAYERS OF MAN AND THE GUINEA‐PIG Get access R. I. C. SPEARMAN, Ph.D., B.Sc., R. I. C. SPEARMAN, Ph.D., B.Sc. Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar P. A. RILEY, Ph.D., M.B. P. A. RILEY, Ph.D., M.B. Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 1, 1 January 1967, Pages 31–42, https://doi.org/10.1111/j.1365-2133.1967.tb11394.x Published: 01 January 1967
Prevalence and incidence of hand eczema in adolescence: report from <scp>BAMSE</scp> – a population‐based birth cohort
Authors: C.M. Grönhagen, C. Lidén, A. Bergström, I. Kull, C.‐F. Wahlgren, B. Meding
Journal: British Journal of Dermatology (2014)

BAMSE is a Swedish population-based birth cohort.To estimate prevalence proportions and the incidence rate of hand eczema in Swedish adolescents, and to compare information given by adolescents and parents. Further aims were to study sex distribution, age at onset and extension of hand eczema.At 16 years of age, 2927 adolescents were included in this study; both adolescent and parental questionnaires were used, as well as clinical examination.The 1-year prevalence of hand eczema was 5·2% (n = 152) and 4·0% (n = 116) (P < 0·03), and lifetime prevalence was 9·7% (n = 284) and 7·0% (n = 206) (P < 0·01), respectively, when adolescents and parents reported. The incidence rate was 573/100 000 person-years according to the adolescent report. The level of agreement between adolescents and parents was fair for 1-year and lifetime prevalence (κ = 0·56 and κ = 0·49, respectively). According to the Hand Eczema Extent Score, 27·0% (n = 36) had moderate-to-severe hand eczema.At the age of 16 years, the 1-year prevalence of hand eczema was substantial, with an incidence rate of the same magnitude as in adults. Female predominance was seen in adolescence. It is preferable that the occurrence of hand eczema is reported by adolescents themselves, as they are the ones most aware of their symptoms.
Calcium Channel Blockers and Myocardial Infarction
Authors: Julie E. Buring
Journal: JAMA (1995)

In this week's<i>JAMA</i>, Psaty and colleagues<sup>1</sup>present findings from a case-control study that raise the possibility, but cannot evaluate definitively, whether calcium channel blockers prescribed for patients with hypertension increase risk of myocardial infarction. This retrospective study among enrollees of the Group Health Cooperative of Puget Sound compared those who had suffered a myocardial infarction (cases) with those who had not (controls), with respect to their prior use of various antihypertensive drug therapies. The authors reported that risk of myocardial infarction increased about 60% (risk ratio=1.6; 95% confidence interval [CI], 1.1 to 2.3) among hypertensive patients treated with a calcium channel blocker compared with those treated with diuretics alone, and this apparent adverse effect was even greater among those treated with high doses. See also p 620. Unfortunately, media reporting of the presentation of these findings at a recent scientific meeting triggered concern among users of these and
Antihypertensive and adverse biochemical effects of bendrofluazide: Authors' reply
Authors: J. E Carlsen, L. Kober, C. Torp-Pedersen, P. Johansen
Journal: BMJ (1990)

to show was that there were true social judgments that were not open to challenge by majority opinion, and to illustrate this he turned to medicine because of the newly emerging confidence being expressed in the absolute truth of the germ theorv of disease.The contemporary belief in the power of this theory was perhaps most clearly shown in the acclaim given to Robert Koch's work on the role of the bacillus in tuberculosis, which was published in the same year as An Enemv ofJthe People.It is unlikely that a playwright would look to medicine for such inspiration today; our confidence in the ability of medical science to solve all ills has declined.Ibsen raised two important questions that remain with us: firstly how to distinguish medical areas from social and political areas and define the relation between them, and, secondly, if we cannot rely on absolute truths in either of these domains, how to assess the claims of the individual as opposed to the majority.
A New Inotropic Drug: Its Promise and a Caution
Authors: Arnold M. Katz
Journal: New England Journal of Medicine (1978)

Cardiology, which rapidly embraced the principles of hemodynamic physiology with the introduction of cardiac catheterization in the late 1940's, has been much slower in adopting the tools of the molecular biologist. It was only in 1954 that most cardiovascular physiologists came to recognize that changes in the biochemical and biophysical processes involved in myocardial contraction played a major part in adjusting the pumping action of the heart to a variety of stimuli and pathologic conditions.1 These adjustments in the mechanical performance of the heart, subsequently referred to as changes in "myocardial contractility," remained ill defined until the 1960's, when attempts . . .
Conversion to mycophenolate mofetil (MMF) instead of cyclosporine a (CYA) in liver transplant (LT) recipients with renal function impairment. A pilot study
Authors: J.I. Herrero, J. Quiroga, B. Sangro, M. Girala, N. Gómez, A. Beltrán, F. Pardo, J.A. Cienfuegos, J. Prieto
Journal: Journal of Hepatology (1998)
Clinical Application of the Ottawa Ankle Rules
Authors: Daniel F. McCarter
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The article on the Ottawa ankle rules by Dr Stiell and colleagues improved emergency department treatment of patients with ankle injuries.<sup>1,2</sup>We would like to share a recent example from our own practice highlighting another potential benefit from implementing these rules. Like much of the eastern United States, we found this past January to be plagued by the worst ice storms in many years. During one particularly bad storm, one of us (D.M.) received a telephone call from the mother of a 7-year-old girl with a possible traumatic ankle fracture. This family lives on the side of a mountain accessible only via an unpaved road. To attempt to reach the child by rescue squad and then transport her 32 km to the nearest radiography facility would have been dangerous. By further questioning the mother, we were able to determine that the child had suffered an inversion
The relationship between blood lead levels and periodontal bone loss in the United States, 1988-1994.
Authors: Bruce A Dye, Rosemarie Hirsch, Debra J Brody
Journal: Environmental Health Perspectives (2002)

An association between bone disease and bone lead has been reported. Studies have suggested that lead stored in bone may adversely affect bone mineral metabolism and blood lead (PbB) levels. However, the relationship between PbB levels and bone loss attributed to periodontal disease has never been reported. In this study we examined the relationship between clinical parameters that characterize bone loss due to periodontal disease and PbB levels in the U.S. population. We used data from the Third National Health and Nutritional Examination Survey (NHANES III), 1988-1994, for the analyses. A total of 10,033 participants 20-69 years of age who completed a periodontal examination and had whole blood tested for lead were examined. Four types of periodontal disease measures were used to indicate oral bone loss: periodontal pocket depth, attachment loss extent, attachment loss severity, and the presence of dental furcations. We found that dental furcations were the best periodontal bone loss indicator for PbB levels (p = 0.005) in a multivariate linear regression model adjusting for sex, age, race/ethnicity, educational attainment, poverty status, smoking, and age of home. Furthermore, after additional modeling, we found a smoking and dental furcation interaction (p = 0.034). Subsequent stratified analyses indicated that current and past smoking is an effect modifier for dental furcations on PbB levels. These findings indicate that increased PbB levels may be associated with advanced periodontal bone loss, particularly among people with a history of smoking.
THE CAUSAL MECHANISM OF DIABETES MELLITUS
Authors: ALBERT A. EPSTEIN
Journal: JAMA (1925)

The presence of an internal secretion in the pancreas and its controlling influence on carbohydrate metabolism have long been surmised. The discovery of insulin fully confirmed this supposition, but the exact mechanism by which diabetes is produced is still problematic. It is now believed that the disease is due to a deficient production of insulin, resulting from a structural or functional change in the islands of Langerhans. In the light of recently acquired knowledge, this explanation seems inadequate. While this disease is undoubtedly due to a lack of insulin, the shortage cannot be ascribed to a simple quantitative reduction in the secretion of this hormone by the pancreas, on either a morphologic or a functional basis. Gross pathologic affections of the pancreas, in the majority of cases, do not produce diabetes. The degenerative changes in the islands of Langerhans noted in some cases of diabetes are absent in others. The
TCT-785 The "Eyeball Test" in Aortic Stenosis: Characterizing Subjective Frailty with Objective Measures
Authors: Tamim Nazif, Philip Green, Christopher W. Hawk, Kishore Harjai, Jean-Michel Paradis, Tiffany Wong, Rosa M. Lazarte, Isaac George, Martin Leon, Ajay J. Kirtane, Mathew Williams, Susheel Kodali
Journal: Journal of the American College of Cardiology (2013)
A memorable doctor: The life of an Egyptian doctor
Authors: S. M. Simaika
Journal: BMJ (2001)

A freezing day on 5 January 1882. “I was born in a state of white asphyxia, the worst form of foetal distress. I was breathless when I was born and did not meet life with screams as most babies do. The midwife and doctor who attended my mother took me for dead. I was placed, together with the placenta, in a copper tray near an open window. My family was told that I was stillborn. Half an hour later my aunt Hana whispered to the midwife that she noticed that the baby was breathing feebly every few minutes whereupon the midwife wrapped me up, cut the cord, and did what she could to resuscitate me.”

From such a precarious start to life, Naguib Mahfouz went on to become the first Egyptian professor …
Lapatinib monotherapy in patients with HER2-overexpressing relapsed or refractory inflammatory breast cancer: final results and survival of the expanded HER2+ cohort in EGF103009, a phase II study
Authors: Bella Kaufman, Maureen Trudeau, Ahmad Awada, Kimberly Blackwell, Thomas Bachelot, Vanessa Salazar, Michelle DeSilvio, Ronald Westlund, Tal Zaks, Neil Spector, Stephen Johnston
Journal: The Lancet Oncology (2009)
US trial of gene therapy for cystic fibrosis
Authors: J. H. Tanne
Journal: BMJ (1999)

Researchers at Stanford University Medical Center in California have started a trial of gene therapy delivered by aerosol to the lungs of patients with cystic fibrosis. The treatment consists of a manufactured version of the faulty cystic fibrosis gene packed inside the shell of a virus.

“We use a manufactured version of the cystic fibrosis transmembrane conductance regulator (CFTR) gene packed into an adeno-associated virus shell. The adeno-associated virus is a small, single stranded RNA virus. It …
Sympathetic activity–associated periodic repolarization dynamics predict mortality following myocardial infarction
Authors: Konstantinos D. Rizas, Tuomo Nieminen, Petra Barthel, Christine S. Zürn, Mika Kähönen, Jari Viik, Terho Lehtimäki, Kjell Nikus, Christian Eick, Tim O. Greiner, Hans P. Wendel, Peter Seizer, Jürgen Schreieck, Meinrad Gawaz, Georg Schmidt, Axel Bauer
Journal: Journal of Clinical Investigation (2014)

Enhanced sympathetic activity at the ventricular myocardium can destabilize repolarization, increasing the risk of death. Sympathetic activity is known to cluster in low-frequency bursts; therefore, we hypothesized that sympathetic activity induces periodic low-frequency changes of repolarization. We developed a technique to assess the sympathetic effect on repolarization and identified periodic components in the low-frequency spectral range (≤0.1 Hz), which we termed periodic repolarization dynamics (PRD).We investigated the physiological properties of PRD in multiple experimental studies, including a swine model of steady-state ventilation (n=7) and human studies involving fixed atrial pacing (n=10), passive head-up tilt testing (n=11), low-intensity exercise testing (n=11), and beta blockade (n=10). We tested the prognostic power of PRD in 908 survivors of acute myocardial infarction (MI). Finally, we tested the predictive values of PRD and T-wave alternans (TWA) in 2,965 patients undergoing clinically indicated exercise testing.PRD was not related to underlying respiratory activity (P<0.001) or heart-rate variability (P=0.002). Furthermore, PRD was enhanced by activation of the sympathetic nervous system, and pharmacological blockade of sympathetic nervous system activity suppressed PRD (P≤0.005 for both). Increased PRD was the strongest single risk predictor of 5-year total mortality (hazard ratio 4.75, 95% CI 2.94-7.66; P<0.001) after acute MI. In patients undergoing exercise testing, the predictive value of PRD was strong and complementary to that of TWA.We have described and identified low-frequency rhythmic modulations of repolarization that are associated with sympathetic activity. Increased PRD can be used as a predictor of mortality in survivors of acute MI and patients undergoing exercise testing.ClinicalTrials.gov NCT00196274.This study was funded by Angewandte Klinische Forschung, University of Tübingen (252-1-0).
Laser treatment of tattoos: A prospective, paired, comparison study of the Q-switched Nd:YAG (1064 NM), frequency-doubled Q-switched Nd:YAG (532 nm), and Q-switched ruby lasers
Authors: Sanjiva Goyal, Kenneth A. Arndt, Robert S. Stern, Deirdre O'Hare, Jeffrey S. Dover
Journal: Journal of the American Academy of Dermatology (1997)
Clinical validation of dialysable calcium in relation to other methods of serum calcium measurement.
Authors: R L Prince, S R Langton
Journal: BMJ (1985)

Dialysable calcium (CaD) values were measured by a simple technique not interfered with by protein bound calcium and validation attempted by comparison with concentrations of ionised calcium (CaI) and clinical categorisation. CaD values were also compared with total calcium (CaT) and albumin adjusted calcium (CaA) concentrations. The normal ranges for CaD, CaT, CaA, and CaI were calculated from the results in healthy blood donors. In 50 normal subjects CaD was more highly correlated with CaI than CaT or CaA. The effects of lying down and of venous stasis in 10 normal subjects showed that CaD was slightly influenced by posture only, whereas CaT was noticeably affected by posture and venous stasis; CaA reduced but did not abolish these effects on CaT. The correlation coefficient of CaD and CaI in patients with chronic renal failure was 0.81. CaD was compared with CaT and CaA values in 293 consecutive hospital patients; discrepant results were obtained in 14.3% and 13.0% of cases respectively and there were some clinical grounds for accepting CaD as correct in 86% and 74% of these cases. Measurement of CaD is a simple, reliable method for estimating accurately the calcium concentration free from biologically inactive protein bound calcium.
Sexual Orientation in Child and Adolescent Health Care; Caring for Lesbian and Gay People: A Clinical Guide
Authors: Sabina Dosani
Journal: BMJ (2004)

Patients' sexual orientation—none of our business, really, is it? Except that lesbian women are more likely than other women to have breast, ovarian, and endometrial cancer. Gay men and women are at higher risk of stroke, coronary artery disease, and lung cancer, and are more likely to commit suicide and to be victims of violence.

Over half of gay adolescents suffer abuse from their families when they disclose their sexual orientation. A third of gay adolescents use alcohol excessively. Gay teenagers represent 30% of all suicides among teenagers. A book to equip heterosexual doctors with the knowledge and …
DEVELOPMENT OF AN AUTOMATED REGISTRATION ALGORITHM FOR DETECTION AND CORRECTION OF PATIENT MOVEMENT IN CARDIAC PET IMAGING
Authors: G C Harris, C K Hoh, M Dahlbom, S Khanna, M DiCarli, R A Hawkins, H R Schelbert, M E Phelps, J Maddahi
Journal: Clinical Nuclear Medicine (1992)

Harris, G. C; Hoh, C. K.; Dahlbom, M.; Khanna, S.; DiCarli, M.; Hawkins, R. A.; Schelbert, H. R.; Phelps, M. E.; Maddahi, J. Author Information
Cyclophosphamide for Ocular Inflammatory Diseases
Authors: Siddharth S. Pujari, John H. Kempen, Craig W. Newcomb, Sapna Gangaputra, Ebenezer Daniel, Eric B. Suhler, Jennifer E. Thorne, Douglas A. Jabs, Grace A. Levy-Clarke, Robert B. Nussenblatt, James T. Rosenbaum, C. Stephen Foster
Journal: Ophthalmology (2009)
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against<i>Salmonella</i>
Authors: Petr Broz, Kim Newton, Mohamed Lamkanfi, Sanjeev Mariathasan, Vishva M. Dixit, Denise M. Monack
Journal: The Journal of Experimental Medicine (2010)

Intracellular pathogens and endogenous danger signals in the cytosol engage NOD-like receptors (NLRs), which assemble inflammasome complexes to activate caspase-1 and promote the release of proinflammatory cytokines IL-1β and IL-18. However, the NLRs that respond to microbial pathogens in vivo are poorly defined. We show that the NLRs NLRP3 and NLRC4 both activate caspase-1 in response to Salmonella typhimurium. Responding to distinct bacterial triggers, NLRP3 and NLRC4 recruited ASC and caspase-1 into a single cytoplasmic focus, which served as the site of pro–IL-1β processing. Consistent with an important role for both NLRP3 and NLRC4 in innate immune defense against S. typhimurium, mice lacking both NLRs were markedly more susceptible to infection. These results reveal unexpected redundancy among NLRs in host defense against intracellular pathogens in vivo.
Detection of Soft Tissue Hemangioma of the Leg by Tc-99m DTPA-HSA Blood Pool Imaging
Authors: MOTOO OSHIMA, HIDEYUKI MURAMAOTO, SADAYUKI SAKUMA
Journal: Clinical Nuclear Medicine (1993)

A 9-year-old girl had pain and swelling of the left distal thigh for 5 months. Radionuclide angiography of leg arteries was performed using Tc-99m DTPA-HSA. Increased blood pooling was observed in the distal thigh and knee joint area of the left leg 20 minutes after the injection. Open biopsy revealed hemangioma in that area. Blood pool imaging using Tc-99m DTPA-HSA is a useful method in the diagnosis of soft tissue hemangioma.
Methods for recording electrograms of the sinoatrial node during cardiac surgery in man.
Authors: R J Hariman, E Krongrad, R A Boxer, F O Bowman, J R Malm, B F Hoffman
Journal: Circulation (1980)

Recent reports have shown that it is possible to record extracellular electrograms from the rabbit and dog sinoatrial (SA) node. We applied similar techniques to record SA nodal activity in 23 patients who underwent cardiac surgery for various forms of heart disease. Both a bipolar technique, using pairs of electrodes at various interelectrode distances, and a unipolar technique, using an exploring and an indifferent electrode, were used. To record SA nodal electrograms, polarity was reversed from the conventional electrocardiographic recording; high amplification (100 microV/cm) and low-pass filters (0.15-20 Hz) were used. SA nodal electrograms were recorded from eight of 12 patients using the bipolar method and from nine of 11 patients using the unipolar method. There were no significant differences in the success rate or quality of the recording between the two methods. However, the unipolar method allowed a more accurate localization of the SA node. Human SA nodal electrograms resembled those of the dog and rabbit and showed two distinct slopes: a diastolic slope and an upstroke slope preceding the P wave of the ECG, SA conduction times were 32.4 +/- 2.8 msec (mean +/- SEM) at sinus (PP) cycle lengths of 587.6 +/- 35.6 msec for the bipolar method, and 38.2 +/- 3.2 msec at sinus (PP) cycle lengths of 712.2 +/- 50.7 msec for the unipolar method. These methods for recording of extracellular SA nodal electrograms in man may prove useful in 1) localization of the SA node during open heart surgery and 2) assessment of SA nodal function in health and disease.