tbuckley/cabot-search huggingface dataset:
Cancer of the liver and the use of oral contraceptives.
Authors: D Forman, T J Vincent, R Doll
Journal: BMJ (1986)

A case-control study of the use of oral contraceptives was conducted among women certified as having died from cancer of the liver in the period 1979-82 and in the age range 20-44 years. An age matched group of women who died from other causes, not related to use of oral contraceptives, in the same period were used as controls. Information about use of oral contraceptives was obtained from the general practitioners9 notes for both cases and controls. Information was obtained for 30 women with histologically confirmed liver cancer, 19 with hepatocellular carcinoma and 11 with cholangiocarcinoma, and for 147 controls. The results were analysed after adjusting for age at diagnosis and year of birth and showed that use of oral contraceptives was associated with a significantly (p less than 0.05) raised relative risk for hepatocellular carcinoma of 3.8 (95% confidence interval 1.0 to 14.6) and use for eight years or more was associated with a significantly (p less than 0.01) increased relative risk of 20.1 (2.3 to 175.7). There were no apparent increases in risk for cholangiocarcinoma. Despite the small number of cases in this study and the methodological problems in assessing use of oral contraceptives from general practitioners9 notes, the results were consistent with other similar studies. Although in the United Kingdom primary liver cancer remains an exceptionally rare disease, especially in young women, further research on the role of oral contraceptives is needed in those countries where it is a much more common disease.
Tight BP control reduced left ventricular hypertrophy in nondiabetic patients with hypertension
Authors: Finlay A. McAlister
Journal: Annals of Internal Medicine (2009)

Source Citation Verdecchia P, Staessen JA, Angeli F, et al. Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial. Lancet. 2009;374:525−33. 19683638
Niels Steensen, M.D. (1638–1686), Scientist and Bishop
Authors: Ian H. Porter
Journal: New England Journal of Medicine (1962)

THE Dane, Niels Steensen,† graduated from the University of Copenhagen when he was twenty-two years old.2 By the time he was thirty-one years of age he had made contributions to anatomy, geology and paleontology that were important milestones in each of these disciplines. At the age of thirty-seven he took Holy Orders, and two years later he was consecrated bishop and appointed vicar apostolic of Hanover. Such is his legend that Pope Pius XI was requested to initiate the formal examination of Steensen's cause for beatification in 1938.His first work in anatomy, carried out in Holland, led to the . . .
Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells.
Authors: P Aparicio, J M Alonso, M L Toribio, M A Marcos, L Pezzi, C Martínez-A
Journal: The Journal of Experimental Medicine (1989)

Lymphocytes isolated from human fetal liver and expanded in vitro in IL-2-containing media reveal the existence of CD4+ gamma, delta T cells. These cells display differential features of double-negative and CD8+ gamma, delta T cells as well as of CD4+ alpha, beta T cells. Thus, they failed to lyse targets in lectin-mediated killing assays and to perform classical helper functions. These results add new information necessary for a better understanding of the physiological role of the gamma, delta T cells.
Who Needs Hexachlorophene? Hospitals and Some People
Authors: Naomi M. Kanof
Journal: JAMA (1972)

Hexachlorophene, the most widely used agent to prevent bacterial overgrowth and limit contamination, is incorporated in untold numbers and kinds of consumer goods. Its merits, touted by some, remain unmentioned by others. In a considerable variety of consumer goods, the rationale for its use is obscure, and its consumer appeal, until now, large. Nonetheless, hexachlorophene fills a health need with scientifically documented effectiveness. It is therefore unfortunate that the Food and Drug Administration has proposed new regulations which will materially restrict the use of hexachlorophene. Among the several problems which the contemplated restrictive regulations create is that of finding a substitute for this antibacterial and preservative substance. If a substitute were immediately available, it would take 20 years of testing and an enormous test population to permit comparison of effectiveness and safety with hexachlorophene's "use test." Were it possible to reduce the time and the sample of testing of such
Importance of the Primer for Dermatology Residents and Students
Authors: Larry E. Millikan
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral Anticoagulant Therapy for Venous Thromboembolism
Authors: David L. Diuguid
Journal: New England Journal of Medicine (1997)

Patients with venous thromboembolic disease require treatment to stop the thrombotic process. The importance of immediate therapy with parenteral anticoagulants or thrombolytic agents (or both) is unquestioned.1,2 Furthermore, several well-designed clinical trials have demonstrated that oral anticoagulant therapy with warfarin derivatives prevents the development of recurrent thromboembolic disease,36 whereas inadequate anticoagulant therapy carries a risk of recurrent thromboembolism that can be as high as 25 percent.5 These studies also show that prolonged anticoagulant therapy is associated with an increased risk of bleeding.36 This risk can be lessened, but not eliminated, by appropriate monitoring of warfarin therapy.7, . . .
Correlation Between Amount of Carbohydrate in Mixed Meals and Insulin Delivery by Artificial Pancreas in seven IDDM Subjects
Authors: Patricia Halfon, Jamil Belkhadir, Gérard Slama
Journal: Diabetes Care (1989)

The effects of mixed meals containing varying amounts of carbohydrate (CHO) on blood glucose levels and insulin delivery by an artificial pancreas were studied in seven insulin-dependent diabetes mellitus subjects. Each patient received, at random over 3 consecutive days, three mixed meals containing 60, 80, and 140 g complex CHOs. There was a high and linear correlation between total amount of insulin delivered to restore blood glucose values and amount of CHO consumed: 12.1 ± 1.3 to 31.2 ± 5.2 U insulin were needed for 116 ± 16 to 198 ± 24 min. However, neither the time lapse between the beginning of meal intake and blood glucose increase nor the peaking time for blood glucose variation were significantly different between meals. We suggest that some of the data obtained in this study might be useful in programming an open-loop insulin-infusion system.
The Forensic Psychiatry Clinic: Model for a New Approach
Authors: ROBERT L. SADOFF, SAMUEL POLSKY, MELVIN S. HELLER
Journal: American Journal of Psychiatry (1967)

The Forensic Psychiatry Clinic at Temple University was established to serve the needs of the indigent and their attorneys in both criminal and civil cases. Closed reports and "private" consultations are provided at the earliest stage of the legal problem. The significance of this type of clinic lies in its versatility and comprehensive approach to the evaluation and treatment of legal-psychiatric problems, its availability for clinical training of lawyers and psychiatrists, and its potential for continued research.
Comparison Of Efficacy Of Once Daily Zyrtec® (cetirizine), Cetrizin® (cetirizine), Desloratadine And Placebo: Suppressive Effects On Allergen And Histamine Induced Wheal And Flare Responses In Allergic Rhinitis Patients
Authors: A. Sukkul, K. Ruxrungtham
Journal: Journal of Allergy and Clinical Immunology (2007)
Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy
Authors: Nicolas Dupont, Sandra Lacas-Gervais, Julie Bertout, Irit Paz, Barbara Freche, Guy Tran Van Nhieu, F. Gisou van der Goot, Philippe J. Sansonetti, Frank Lafont
Journal: Cell Host & Microbe (2009)
Home From the War: A Study of Psychiatric Problems in Viet Nam Returnees
Authors: ROBERT E. STRANGE, DUDLEY E. BROWN
Journal: American Journal of Psychiatry (1970)

Fifty patients who developed psychiatric problems after return from tours of Viet Nam combat duty were compared with a group of patients who had not had such duty. The Viet Nam returnees reported more conflicts in intimate relationships and had a higher incidence of depression and somatization than did the noncombat group. Although the returnees manifested more aggressive and suicidal threats, they did not evidence more direct aggressive or suicidal behavior. The authors suggest that although Viet Nam returnees face significant readjustment stress, their reactions are generally internalized and their potential for violent aggression is no greater than in those without Viet Nam experience.
Initial management of suspected meningococcal infection
Authors: C S Nanayakkara, R Cox
Journal: BMJ (1994)

EDITOR, - The overall mortality and morbidity in childhood bacterial meningitis have changed little over the past three decades despite the availability of an effective range of antibiotics. Since the introduction of Haemophilus influenzae type b vaccine the incidence of serious haemophilus infections has fallen dramatically. The initial management of meningococcal infections has therefore become relatively more important and may even have …
The kinetics of metaphase arrest in human psoriatic epidermis: an examination of optimal experimental conditions for determining the birth rate
Authors: IAN RALFS, RODNEY DAWBER, TERENCE RYAN, MARK DUFFILL, NICHOLAS A. WRIGHT
Journal: British Journal of Dermatology (1981)

Journal Article The kinetics of metaphase arrest in human psoriatic epidermis: an examination of optimal experimental conditions for determining the birth rate Get access IAN RALFS, IAN RALFS Department of Dermatology, University of Oxford, Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar RODNEY DAWBER, RODNEY DAWBER Department of Dermatology, University of Oxford, Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar TERENCE RYAN, TERENCE RYAN Department of Dermatology, University of Oxford, Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar MARK DUFFILL, MARK DUFFILL Department of Dermatology, Hamilton Hospital, New Zealand Search for other works by this author on: Oxford Academic Google Scholar NICHOLAS A. WRIGHT NICHOLAS A. WRIGHT Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, London W12 oHS Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 104, Issue 3, 1 March 1981, Pages 231–242, https://doi.org/10.1111/j.1365-2133.1981.tb00943.x Published: 01 March 1981 Article history Accepted: 16 May 1980 Published: 01 March 1981
Graft-versus-host-induced cirrhosis: Possible mechanisms
Authors: Howard M. Shulman
Journal: Hepatology (1987)

A 28-yr-old woman with severe idiopathic aplastic anemia received an HLA-identical mixed lymphocyte culture nonreactive bone marrow transplant from her brother. In the months after successful engraftment, she developed cutaneous and hepatic graft-versus-host disease, associated with marked cholestatic jaundice. Despite a series of therapeutic maneuvers, cholestasis persisted but remained relative stable over the enuing 10 yr. However, serial liver biopsies revealed progressive biliary-type firbrosis culminating in cirrhosis. Subsequently, her clinical course deteriorated and she developed signs of hepatic failure, and ultimately died 10.5 yr after bone marrow transplantation. The evolution of chronic graftversus-host disease to cirrhosis may be a limiting factor in the long-term survival of this group of bone marrow transplant recipients. The lack of correlation between the stable clinical or biochemical indices and the progressive hepatic disease underscores the need for sequential liver biopsies in patients with sustained liver function abnormalities after bone marrow transplantation.
Legal Aspects of Health Care Administration
Authors: Jonathan B. Perlin
Journal: Annals of Internal Medicine (2002)

Medical Writings: Book Notes6 August 2002Legal Aspects of Health Care AdministrationJonathan B. Perlin, MD, PhD, MSHAJonathan B. Perlin, MD, PhD, MSHAOffice of Quality & Performance, Veterans Health Administration, Department of Veterans Affairs, Washington, D.C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-3-200208060-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 8th edition. Pozgar GD, Santucci NM. 487 pages. Gaithersburg, MD: Aspen Publishers; 2002. $69.00. ISBN 0834219115. Order phone 800-638-8437.Field of medicine: Health systems administration and health law.Format: Hardcover book.Audience: The stated audience is health administrators and health care practitioners; however, the book may also be useful for health administration students requiring an introduction to health law and the clinical and administrative contexts in which legal issues arise. Although not encyclopedic, this volume would be useful for clinicians and administrators framing questions for discussion with professional counsel.Purpose: To provide a foundation of health law, enabling health care ... Author, Article, and Disclosure InformationAffiliations: Office of Quality & Performance, Veterans Health Administration, Department of Veterans Affairs, Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 August 2002Volume 137, Issue 3Page: 224KeywordsBioethicsHealth careHealth care providersHealth information technologyHealth insuranceMedical lawMedical staffPatientsSoftware toolsVeteran care ePublished: 6 August 2002 Issue Published: 6 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Association of Herpes Virus Infection of the Esophagus and Idiopathic Inflammatory Bowel Disease
Authors: B. Wörmann, A. Sommer, R. Ottenjann
Journal: Endoscopy (1985)

A case of relapsing ulcerative esophagitis presumably due to herpes virus infection in temporary association with two relapses of an idiopathic inflammatory bowel disease is reported.
Selective deficiency of pancreatic amylase.
Authors: K Sjolund, A Haggmark, I Ihse, G Skude, U Karnstrom, M Wikander
Journal: Gut (1991)

Two patients with specific pancreatic amylase deficiency are described. The greatly reduced pancreatic amylase activity was not due to an enzymatically inactive amylase molecule but to an almost complete absence of the molecule itself. The findings are of diagnostic importance as they show that low pancreatic amylase activity in serum or duodenal aspirates, or both, does not necessarily represent chronic exocrine pancreatic disease such as chronic pancreatitis, carcinoma of the pancreas, or cystic fibrosis but may be an isolated finding. In one of our patients a familial occurrence was shown, indicating a congenital deficiency.
Associations of Serum Concentrations of Persistent Organic Pollutants with the Prevalence of Periodontal Disease and Subpopulations of White Blood Cells
Authors: Duk-Hee Lee, David R. Jacobs, Thomas Kocher
Journal: Environmental Health Perspectives (2008)

Persistent organic pollutants (POPs), which are endocrine disruptors that accumulate in adipose tissue, can increase the risk of periodontal disease through the disturbance of the immune system.We examined associations of background exposure to POPs with periodontal disease in the general population.Cross-sectional associations of concentrations of serum POPs with the prevalence of periodontal disease were investigated in 1,234 adults > or = 20 years of age in the National Health and Nutrition Examination Survey 1999-2002.Among several POPs, organochlorine (OC) pesticides were most strongly associated with periodontal disease. Adjusted odds ratios across quintiles of OC pesticides were 1.0, 1.3, 1.7, 2.4, and 2.7 (p for trend < 0.01) for the presence in any site of clinical attachment loss > or = 4 mm and 1.0, 1.7, 2.6, 3.4, and 3.7 (p for trend < 0.01) for the presence of pocket depth > or = 4 mm. Polychlorinated biphenyls and polychlorinated dibenzo-p-dioxins also showed significant positive associations with one or both definitions of periodontal disease. Results did not materially change when continuous variables of clinical attachment loss or pocket depth were used as outcomes. Although participants with periodontal disease had higher white blood cell and neutrophil counts, neutrophil counts were inversely related to OC pesticides (p for trend < 0.01). These inverse associations did not change after excluding subjects with C-reactive protein >/= 3 mg/L.POPs, especially OC pesticides, were positively associated with periodontal disease, possibly through immunomodulation due to OC pesticides.
Alterations in serum immunoglobulins after resection for ulcerative and granulomatous disease of the intestine
Authors: I. M. Gelernt, D. H. Present, H. D. Janowitz
Journal: Gut (1972)

Following resections for ulcerative colitis and granulomatous enteritis there is a significant rise in serum IgM levels. The rise seen in IgM following resection does not occur after bypass surgery. No consistent changes were noted in the concentrations of IgA or IgG. There was no observed difference noted between patients with ulcerative colitis and granulomatous enteritis in the IgM response following resection. The results resemble those which occur after the surgical removal of an allograft which is in process of being rejected.
STAT3 Polymorphism Can Predict the Response to Interferon-α Therapy in Patients with Metastatic Renal Cell Carcinoma
Authors: Masatoshi Eto, Tomomi Kamba, Hideaki Miyake, Masato Fujisawa, Takao Kamai, Hirotsugu Uemura, Taiji Tsukamoto, Haruhito Azuma, Akio Matsubara, Kazuo Nishimura, Tsuyoshi Nakamura, Osamu Ogawa, Seiji Naito
Journal: European Urology (2012)
COMPARISON OF HISTOPATHOLOGICAL ANALYSIS OF INTRACORONARY THROMBUS ASPIRATED BY THROMBECTOMY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH AND WITHOUT ST-SEGMENT ELEVATION
Authors: Roberta Montisci, Massimo Ruscazio, CInzia Soro, Cristina Cacace, Antonio Bracco, Giorgio Lai, Mauro Cadeddu, Raimondo Pirisi, Maria Letizia Lai, Gavino Faa, Luigi Meloni
Journal: Journal of the American College of Cardiology (2013)
Systemic Lupus Erythematosus: Emerging Concepts: Part 1: Renal, Neuropsychiatric, Cardiovascular, Pulmonary, and Hematologic Disease
Authors: Dimitrios T. Boumpas
Journal: Annals of Internal Medicine (1995)

Purpose: To review advances and controversies in the diagnosis and management of systemic lupus erythematosus with visceral involvement (renal, neuropsychiatric, cardiopulmonary, and hematologic disease). Data Sources and Study Selection: Review of the English-language medical literature with emphasis on articles published in the last 5 years. More than 400 articles were reviewed. Data Synthesis: Recent debates pertaining to lupus nephritis have focused on the value of kidney biopsy data and the role of cytotoxic drug therapies. Many studies have shown that estimates of prognosis are enhanced by consideration of clinical, demographic, and histologic features. For patients with severe lupus nephritis, an extended course of pulse cyclophosphamide therapy is more effective than a 6-month course of pulse methylprednisolone therapy in preserving renal function. Adding a quarterly maintenance regimen to monthly pulse cyclophosphamide therapy reduces the rate of exacerbations. Plasmapheresis appears not to enhance the effectiveness of prednisone and daily oral cyclophosphamide. Small case series have shown pulses of cyclophosphamide to be beneficial in patients with lupus and neuropsychiatric disease refractory to glucocorticoid therapy, acute pulmonary disease (pneumonitis or hemorrhage), and thrombocytopenia. Patients with systemic lupus erythematosus have an increased prevalence of valvular and atherosclerotic heart disease, apparently because of factors related to the disease itself and to drug therapy. Conclusions: Cytotoxic agents are superior to glucocorticoid therapy for the treatment of proliferative lupus nephritis, but the optimal duration and intensity of cytotoxic therapy remain undefined. Definitive studies of the treatment of autoimmune thrombocytopenia and acute pulmonary disease and of the diagnosis and treatment of neuropsychiatric disease are not available.
A “PSA Pyramid” for Men with Initial Prostate-specific Antigen ≤3 ng/ml: A Plea for Individualized Prostate Cancer Screening
Authors: Marco Randazzo, Josef Beatrice, Andreas Huber, Rainer Grobholz, Lukas Manka, Felix K. Chun, Franz Recker, Maciej Kwiatkowski
Journal: European Urology (2014)
Regulation by miR181 Family of the Dependence Receptor CDON Tumor Suppressive Activity in Neuroblastoma
Authors: Benjamin Gibert, Céline Delloye-Bourgeois, Charles-Henry Gattolliat, Olivier Meurette, Solen Le Guernevel, Joanna Fombonne, Benjamin Ducarouge, Fabrice Lavial, Frantz Bouhallier, Marion Creveaux, Ana Maria Negulescu, Jean Bénard, Isabelle Janoueix-Lerosey, Annick Harel-Bellan, Olivier Delattre, Patrick Mehlen
Journal: JNCI Journal of the National Cancer Institute (2014)

BackgroundThe Sonic Hedgehog (SHH) signaling pathway plays an important role in neural crest cell fate during embryonic development and has been implicated in the progression of multiple cancers that include neuroblastoma, a neural crest cell-derived disease. While most of the SHH signaling is mediated by the well-described canonical pathway leading to the activation of Smoothened and Gli, it has recently been shown that cell-adhesion molecule-related/downregulated by oncogenes (CDON) serves as a receptor for SHH and contributes to SHH-induced signaling. CDON has also been recently described as a dependence receptor, triggering apoptosis in the absence of SHH. This CDON proapoptotic activity has been suggested to constrain tumor progression.