EXPERIMENTAL AND CLINICAL STUDIES OF ERGOTAMINE
Authors: JOHN B. YOUMANS
Journal: Annals of Internal Medicine (1933)

Article1 November 1933EXPERIMENTAL AND CLINICAL STUDIES OF ERGOTAMINEV. THE ACTION OF ERGOTAMINE ON THE SYMPATHETIC NERVOUS SYSTEM STIMULATED BY EPINEPHRINE. STUDIES OF THE METABOLIC RATE, PULSE RATE, BLOOD PRESSURE, BLOOD SUGAR AND THE TOTAL LEUKOCYTE COUNT*JOHN B. YOUMANS, M.D., F.A.C.P., CHARLES TRABUE, M.D., RALPH S. BUVINGER, M.D., HELEN FRANK, B.A.JOHN B. YOUMANS, M.D., F.A.C.P.Search for more papers by this author, CHARLES TRABUE, M.D.Search for more papers by this author, RALPH S. BUVINGER, M.D.Search for more papers by this author, HELEN FRANK, B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-5-653 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous paper1it was shown that in human subjects, under basal conditions, ergotamine had little or no effect on those motor divisions of the sympathetic nervous system concerned with the regulation of the blood sugar level or the basal metabolic rate. Evidence was given for the belief that the slowing of the pulse was the result of vagus stimulation rather than depression of the sympathetic. It was suggested at that time that the failure of ergotamine to depress certain of these motor functions of the sympathetic nervous system might be explained if the latter were inactive2in the...Bibliography1. YOUMANSTRIMBLEFRANK JBWHH: Experimental and clinical studies of ergotamine. IV. The effect of ergotamine on basal metabolism, circulation and blood sugar of normal persons and of patients with thyrotoxicosis, Arch. Int Med., 1931, xlvii, 612-632. CrossrefGoogle Scholar2. CANNON WB: Organization for physiological homeostasis, Physiol. Rev., 1929, ix, 399-431. CrossrefGoogle Scholar3. FOLIN OK: Laboratory manual of biological chemistry with supplement, 1925, D. Appleton and Company, New York, p. 308. Google Scholar4. DALE HH: On some physiological actions of ergot, Jr. Physiol., 1906, xxxiv, 163-206. CrossrefGoogle Scholar5. GOLDMAN M: Recherches cliniques sur l'action de l'ergotamine sur le système végétatif, Arch. d. mal du cœur, 1928, xxi, 204-209. Google Scholar6. MORETTI H: L'action hypoglycémiante de l'ergotamine dans le diabète, Compt rend. Soc. de biol., 1927, xcvii, 320-324. Google Scholar7. COELHODE OLIVEIRA EJC: Influence de l'ergotamine sur l'hyperglycémie alimentaire chez les sujets normaux et chez les diabétiques, Compt. rend. Soc. de biol., 1928, xcix, 1527-1530. Google Scholar8. YOUMANSTRIMBLE JBWH: Experimental and clinical studies of ergotamine. I. Effect of ergotamine on blood sugar and epinephrine hyperglycemia in trained unanesthetized dogs, Jr. Pharmacol. and Exper. Therap., 1930, xxxviii, 121-132. Google Scholar9. WILDER J: Ein unbeachtetes biologisches Gesetz, seine Bedeutung für Forschung und Praxis, Wien. klin. Wchnschr., 1931, xliv, 1299-1304. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nashville, Tennessee*Received for publication March 6, 1933.From the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byActions on the Heart and CirculationEffects of Adrenaline and Ergotamine on the Oxygen Consumption 1 November 1933Volume 7, Issue 5Page: 653-663KeywordsBlood sugarHeart rateSympathetic nervous system Issue Published: 1 November 1933 PDF downloadLoading ...