tbuckley/cabot-search huggingface dataset:
The Contribution of the Interview Situation to the Restriction of Fantasy Life and Emotional Experience in Psychosomatic Patients
Authors: Heinz H. Wolff
Journal: Psychotherapy and Psychosomatics (1977)

Discussions| February 16 2010 The Contribution of the Interview Situation to the Restriction of Fantasy Life and Emotional Experience in Psychosomatic Patients Subject Area: Psychiatry and Psychology Heinz H. Wolff Heinz H. Wolff London Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1977) 28 (1-4): 58–67. https://doi.org/10.1159/000287044 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Heinz H. Wolff; The Contribution of the Interview Situation to the Restriction of Fantasy Life and Emotional Experience in Psychosomatic Patients. Psychother Psychosom 31 December 1977; 28 (1-4): 58–67. https://doi.org/10.1159/000287044 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1977Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Empirical Anti-<i>Candida</i> Therapy among Selected Patients in the Intensive Care Unit: A Cost-Effectiveness Analysis
Authors: Yoav Golan, Michael P. Wolf, Stephen G. Pauker, John B. Wong, Susan Hadley
Journal: Annals of Internal Medicine (2005)

Mortality from invasive candidiasis is high. Low culture sensitivity and treatment delay contribute to increased mortality, but nonselective early therapy may result in excess costs and drug resistance.To determine the cost-effectiveness of anti-Candida strategies for high-risk patients in the intensive care unit (ICU).Cost-effectiveness decision model.Published data to 10 May 2005, identified from MEDLINE and Cochrane Library searches, ICU databases, expert estimates, and actual hospital costs.Patients in the ICU with suspected infection who have not responded to antibacterial therapy.Lifetime.Societal.Fluconazole, caspofungin, amphotericin B, or lipid formulation of amphotericin B given as either empirical or culture-based therapy and no anti-Candida therapy.Incremental life expectancy and incremental cost per discounted life-year (DLY) saved.Ten percent of the target population will have invasive candidiasis. Empirical caspofungin therapy is the most effective strategy but is expensive (295,115 dollars per DLY saved). Empirical fluconazole therapy is the most reasonable strategy (12,593 dollars per DLY saved) and decreases mortality from 44.0% to 30.4% in patients with invasive candidiasis and from 22.4% to 21.0% in the overall target cohort.Empirical fluconazole therapy is reasonable for likelihoods of invasive candidiasis greater than 2.5% or fluconazole resistance less than 24.0%. For higher resistance levels, empirical caspofungin therapy is preferred. For low prevalences of invasive candidiasis, culture-based fluconazole is reasonable. For prevalences exceeding 60%, empirical caspofungin therapy is reasonable. For caspofungin to be reasonable at a prevalence of 10%, its cost must be reduced by 58%.Less severe illness and limited use of broad-spectrum antimicrobial agents, typical of smaller hospitals, could result in a lower risk for invasive candidiasis.In patients in the ICU with suspected infection who have not responded to antibiotic treatment, empirical fluconazole should reduce mortality at an acceptable cost. The use of empirical strategies in low-risk patients is not justified.
Incorporation of chylomicron fatty acids into the developing rat brain.
Authors: G J Anderson, P S Tso, W E Connor
Journal: Journal of Clinical Investigation (1994)

The developing brain obtains polyunsaturated fatty acids from the circulation, but the mechanism and route of delivery of these fatty acids are undetermined. 14C-labeled chylomicrons were prepared by duodenal infusion of [1-14C]16:0, [1-14C]18:2(n-6), [1-14C]18:3(n-3), or [1-14C]22:6(n-3) into adult donor rats, and were individually injected into hepatectomized 2-wk-old suckling rats. After minor correction for trapped blood in the brain, the incorporation of chylomicron fatty acids after 30 min was nearly half that of a co-injected free fatty acid reference. [1-14C]22:6(n-3)-labeled chylomicrons showed an average 65% greater incorporation than chylomicrons prepared from the other fatty acids. This apparent selectivity may have been partly due to lower oxidation of 22:6(n-3) in the brain compared to the other fatty acids tested, based on recovered water-soluble oxidation products. The bulk of the radioactivity in the brain was found in phospholipid and triacylglycerol, except that animals injected with [1-14C]22:6(n-3) chylomicrons showed considerable incorporation also into the fatty acid fraction instead of triacylglycerol. These data show that chylomicrons may be an important source of fatty acids for the developing rat brain.
THE SUN CURE AND THE WORK CURE IN SURGICAL TUBERCULOSIS
Authors: A. Rollier
Journal: BMJ (1929)

HELIOTHER.M11Y h.as COIIe to be associated especially withl higlh altitudes ill the Swiss Alps.More thanl a quarter of a ceintury ago thie filst clinic for the treatiulenit of surgical tuberculosis by geileral and systematized lleliotherapy was opeiied by me at Leysill, aild the results have proved so fas ouri able that lheliotherapy lias becomiie recogiiized as tho treatmelnt par excellenice for surgical tuberculosis.Leysin is situated in Switzerland, overlooking the upper Rh6noe valley and facing tile p)icturesque ridge of the Dent du Midi alnd lleighbouiring snow-capped peaks.Altlhough its height is betweeni 4,000 alnd 5,000 feet, the site is protected fronm the niorth willds by pine-clad up- lands aiid it slopes steeply towards the southern sun.TIle air is tller efore still, and the daily amount of sllllshine is exceptio'nally great, both in willter and in suminmer, so tlhat heliotherapy caln he practised liere all the year rounid.The idea of a worlk cure for bed-riddeln patients is of iolie recent intioduction, alid miglht at first sighit appear to be a conitradictioni inl ternis.Occupational therapy has for lolig beell applied to collsuimiptive patients-for example, by George Bodingtoll (1840)-and ill lmore recen-t times by, Dr. Marcus Paterson, who, at Frimley, presciribed
Hearing Loss in the Sjogren Syndrome
Authors: Bruno Tumiati
Journal: Annals of Internal Medicine (1997)

Ear involvement is not unusual in autoimmune diseases, but few data on this problem in the Sjögren syndrome are available.To determine whether the incidence of hearing loss is increased in patients with the Sjögren syndrome and to determine what factors might be involved in the pathogenesis of Sjögren syndrome-related hearing loss.Cross-sectional study.Secondary referral center in Italy.30 women with the Sjögren syndrome were evaluated for evidence of audiovestibular disorder. Their results were compared with those of 40 age-matched healthy women.Evaluation techniques included pure tone audiometry thresholds at octave frequencies of 125 Hz to 8000 Hz, tympanometry, and the stapedial reflex test in both ears. The presence of vasculitis, the Raynaud phenomenon, nervous system involvement, and serum anticardiolipin antibodies was recorded.14 patients with the Sjögren syndrome (46% [95% CI, 28% to 66%]) had sensorineural hearing loss. Only one control (2.5% [CI, 0.06% to 13%]) had a similar hearing impairment (P < 0.001). Nine of the 14 patients who had the Sjögren syndrome and sensorineural hearing loss (64% [CI, 36% to 87%]) had anticardiolipin antibodies compared with only 3 controls (18% [CI, 4% to 45%]) (P = 0.02).The high prevalence of hearing loss in the Sjögren syndrome supports the value of doing audiometric studies before excluding cranial nerve involvement in this disease. The correlation of sensorineural hearing loss with anticardiolipin antibodies must be investigated further.
Abstract 2284: MIR-200 family as EMT related microRNA in renal cell carcinoma
Authors: Hideki Enokida, Hirofumi Yoshino, Takeshi Yamasaki, Hideo Hidaka, Takeshi Chiyomaru, Nijiro Nohata, Naohiko Seki, Masayuki Nakagawa
Journal: Cancer Research (2012)

Abstract (Background) Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney, and clear cell RCC represents the most common renal cancer histology. However surgical treatment is provided for localized disease, relapse or metastasis of the patient is caused in a considerable ratio. At present, metastatic RCC is difficult to treat and the process of metastasis is not well understood. Therefore, it is crucial to find molecular mechanisms based on recent genome analysis in RCC oncogenesis and metastasis. Based on the microRNA (miRNA) expression signature of RCC revealed that miR-200 family significantly reduced in RCC cells. The miR-200 family (miR-200b, miR-200a and miR-429 are encoded by single polycistronic transcript on chromosome 1p36.33 and miR-200c and miR-141 are cluster on chromosome 12 p13.31) of miRNA plays a major role to epithelial to mesenchymal transition (EMT) by targeting transcription repressors, zinc-finger E-box binding homeobox (ZEB1) and ZEB2. In this study, we investigated the functional significance of miR-200 family and identified the novel cancer pathways in RCC. (Methods) Cell proliferation and invasion assay was performed by restoration of mature miR-200 family (miR-200a, miR-200b, miR-200c, miR-429 and miR-141) in RCC cell lines. Genome-wide gene expression analysis was performed to identify the molecular networks of miR-200 family by microarray analysis. (Results) The mRNA expression levels of ZEB1 and ZEB2 were significantly decreased by miR-200 family (miR-200a, miR-200b, miR-200c, miR-429 and miR-141) transfectantion in RCC cells. Restoration of each miRNAs significantly inhibited cell proliferation and invasion in RCC cells. Interestingly, the morphological changes were recognized by miR-200 family transfection in RCC cell lines. Gene expression analysis showed more than ten candidate genes were searched for miR-200 family targets and these genes were up-regulated in RCC clinical specimens. (Conclusions) Our data suggest that miR-200 family function as tumor suppressors in RCC. EMT-related tumor suppressive miR-200 family mediates novel molecular targets provide new insights into the potential mechanisms of RCC oncogenesis and metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2284. doi:1538-7445.AM2012-2284
Natural HIV Inhibitor
Authors: Joan Stephenson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SHEDDING OF NAILS APPARENTLY INDUCED BY THE ADMINISTRATION OF LARGE AMOUNTS OF CEPHALORIDINE AND CLOXACILLIN IN TWO ANEPHRIC PATIENTS
Authors: J. B. EASTWOOD, J. R. CURTIS, E. K. M. SMITH, H. E. WARDENER
Journal: British Journal of Dermatology (1969)

SUMMARY.— Two anephric patients on twice weekly maintenance haemodi‐alysis developed staphylococcal infections of their Scribner Teflon‐silastic arteriovenous shunts. Both patients were treated with very large doses of cephaloridine and cloxacillin in an attempt to preserve the shunts. Shedding of finger and toe nails developed in both patients some 6 to 12 weeks after the start of antibiotic therapy. Regrowth of the nails occurred normally.
Circulating nucleated red blood cells following splenectomy in a patient with congenital dyserythropoietic anemia
Authors: Christopher D. Adams, John F. Kessler
Journal: American Journal of Hematology (1991)

Abstract A 24‐year‐old white female with a 10‐year history of juvenile rheumatoid arthritis and splenomegaly developed numerous circulating nucleated red blood cells (NRBC) following splenectomy for chronic abdominal pain. Subsequent evaluation revealed the presence of a congenital dyserythropoietic anemia (CDA) with atypical features. Circulating NRBCs have been reported following splenectomy in three other cases of CDA, each of which had atypical features and did not fit into the customary classification of types I–IV. Follow‐up of our patient at 4 years revealed no untoward consequences of persistent NRBCs in her circulation.
Mismatch Repair Gene <b> <i>PMS2</i> </b>
Authors: Hidewaki Nakagawa, Janet C. Lockman, Wendy L. Frankel, Heather Hampel, Kelle Steenblock, Lawrence J. Burgart, Stephen N. Thibodeau, Albert de la Chapelle
Journal: Cancer Research (2004)

Abstract The MutLα heterodimer formed by mismatch repair (MMR) proteins MLH1 and PMS2 is a major component of the MMR complex, yet mutations in the PMS2 gene are rare in the etiology of hereditary nonpolyposis colorectal cancer. Evidence from five published cases suggested that contrary to the Knudson principle, PMS2 mutations cause hereditary nonpolyposis colorectal cancer or Turcot syndrome only when they are biallelic in the germline or abnormally expressed. As candidates for PMS2 mutations, we selected seven patients whose colon tumors stained negative for PMS2 and positive for MLH1 by immunohistochemistry. After conversion to haploidy, truncating germline mutations of PMS2 were found in two patients (2192delTAACT and deletion of exon 8). These mutations abrogated PMS2 protein in germline cells by Western analysis. In two additional patients, PMS2 protein from one allele also was abrogated. Novel or previously described missense variants of PMS2 were detected, but their pathogenicity is undetermined. We detected and characterized a new transcript, PMS2CL, showing 98% sequence identity with exons 9 and 11–15 of PMS2 and emanating from a locus close to PMS2 in chromosome 7p. Its predicted protein product was not detected. Thus, in addition to several previously described PMS2-related genes resembling the 5′ end of PMS2, at least one related gene resembles the 3′ end of PMS2. In conclusion, both detectable and presently undefined germline mutations are deleterious and produce susceptibility to cancer by the two-hit mechanism. Paralogous genes interfere with mutation detection, resulting in underdiagnosis of PMS2 mutations. Mutation detection in PMS2 requires haploid DNA.
S76. Adoptive cell therapy of melanoma with autologous tumour infiltrating lymphocytes
Authors: I Svane, R Andersen, M Donia
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Adoptive T-cell therapy (ACT) with tumor infiltrating lymphocytes (TILs) is a personalized treatment for cancer defined as the infusion of T cells isolated from the patient’s own tumor tissue after ex vivo activation and several rounds of expansion. This treatment has achieved
REPORT OF THE TREATMENT OF SIX GRAVE CASES OF TYPHOID FEVER WITHOUT ALCOHOL.
Authors: KATE LINDSAY
Journal: JAMA (1895)

The use of any remedy empirically declines always in proportion to increased knowledge of facts and the approach to exactness in medical science in all its branches. When the treatment of disease consisted almost entirely of a medication of symptoms and no fixed rules or indications regulated the giving of drugs, many remedies were used because of precedent and without any other virtue to recommend them for the cure of disease. At the present, when rational ideas about the causes, course, and all other phenomena of disease are found, collected and classified from actual knowledge of these subjects, and the progressive medical mind is not satisfied with the therapeutics of the past, many remedies and methods of treatment, some of them very popular, have been superseded by other and more rational methods of dealing with disease. Preventive medicine has come to the front in many departments of healing, notably in
EFFECTS OF BETA BLOCKERS ON MYOCARDIAL MECHANICS IN HYPERTROPHIC CARDIOMYOPATHY
Authors: Chiara Pisanello, Hongchang Luo, Iraklis Pozios, Lars Sorensen, HsinYueh Liang, Filippo Crea, M. Roselle Abraham, Theodore Abraham
Journal: Journal of the American College of Cardiology (2014)
Scotland considers radical reform of hospital services
Authors: B. Christie
Journal: BMJ (1997)

A review is to be conducted into the way hospital services are delivered in Scotland to ensure that patients are being given the highest standard of clinical treatment. The announcement has led to fears that certain services could be withdrawn from local hospitals and concentrated instead on larger, specialist centres.

The review was announced in a government white paper, The Scottish Health Service: Ready for the Future , which maps out a strategy to take the NHS in Scotland into the next century. It emphasises the …
Prognostic Significance of Visible Lesions on Transrectal Ultrasound in Impalpable Prostate Cancers: Implications for Staging
Authors: Herbert Augustin, Markus Graefen, Jüri Palisaar, Jakob Blonski, Andreas Erbersdobler, Fedor Daghofer, Hartwig Huland, Peter G. Hammerer
Journal: Journal of Clinical Oncology (2003)

Purpose: The current tumor-node metastasis (TNM) staging system classifies impalpable prostate cancers identified by needle biopsy and invisible by imaging as T1c and those visible as T2. Palpable cancers are classified as at least T2. However, most urologists consider impalpable prostate cancers T1c tumors, irrespective of findings on transrectal ultrasound (TRUS). The aim of this article is to provide a differentiated view of the significance of TRUS findings for staging purposes in impalpable prostate cancers. Patients and Methods: A consecutive series of 1,670 patients with impalpable tumors and palpable T2 cancers after radical prostatectomy were evaluated. Tumor characteristics and 5-year biochemical cure rates of cancers invisible and visible on TRUS were compared, as well as the rates of impalpable but visible and palpable T2 cancers. Results: Impalpable cancers invisible on TRUS presented significantly more favorable pathologic stages and lower cancer volumes than those visible on TRUS (P = .002, P = .010). In the latter, these clinical features were more favorable compared with T2 cancers (P &lt; .001, P &lt; .001). Progression-free probability of impalpable cancers invisible on TRUS was 86.8%; progression-free probability for impalpable cancers visible on TRUS was 85.4% (log-rank test P = .2060). The corresponding rate for T2 tumors was 73.9%, significantly lower when compared to those of visible and impalpable cancers (log-rank test P = .0001). Conclusion: Impalpable prostate cancers invisible on TRUS present more favorable cancer features than those that are visible on TRUS. However, these differences are not as pronounced as those between impalpable but visible cancers and palpable T2 tumors. Thus, based on our data, it seems inappropriate to classify impalpable prostate cancers visible on TRUS as T2 cancers.
Foundation allocation of 148 students is changed in wake of scanning error
Authors: T. Moberly
Journal: BMJ (2013)

Foundation school allocations of 148 medical students have changed after the remarking of applicants’ exam papers, the UK Foundation Programme Office (UKFPO) has announced.

On 8 March the UKFPO announced the final revised allocations of 7535 applicants, 98% of whom were given the same allocation as they originally received on 25 February. Of those whose scores changed, 77 were allocated to a foundation school lower down their list of preferences and …
Human adipose tissue as a source of Flk-1 cells: new method of differentiation and expansion
Authors: O MARTINEZESTRADA, Y MUNOZSANTOS, J JULVE, M REINA, S VILARO
Journal: Cardiovascular Research (2004)

The low number of postnatal endothelial progenitor cells (EPC) in the circulation limits their therapeutic application in cardiovascular medicine. Processed lipoaspirate (PLA) cells differentiate into osteoid, adipose, muscle, and cartilaginous cells. This study examines the potential of PLA cells as a source of EPCs.PLA cells obtained from human lipoaspirates were cultured for 1 week in serum-depleted medium to form three-dimensional cell clusters (3DCC). The phenotype of 3DCC-derived cells was assessed by immunofluorescence staining and FACS analysis.Flow cytometry showed that 45+/-5% of cells derived from the 3DCC expressed Flk-1, a marker of early EPC, whilst only 4+/-0.5% of freshly isolated PLA were Flk-1+. The proportion of Flk-1+ cells increased to 98+/-2% during culture in hematopoietic stem cell medium. When cultured in an endothelial cell (EC)-specific medium, Flk-1+ cells also expressed Ve-cadherin, von Willebrand's factor (vW), and a lectin receptor, and took up low-density lipoprotein. Incorporation into an endothelial cell tubular network confirmed their functional activity.This report describes the first isolation and culture of Flk-1+ cells from human adipose tissue. The feasibility of the extraction and culture of these cells in increased numbers suggests that such autologous cells will be useful for applications ranging from basic research to cell-based therapies.