The Cortisone-Glucose Tolerance Test
Authors: THOMAS POZEFSKY
Journal: Annals of Internal Medicine (1965)

Article1 December 1965The Cortisone-Glucose Tolerance TestThe Influence of Age on PerformanceTHOMAS POZEFSKY, M.D., JOEL L. COLKER, M.D., HAROLD M. LANGS, M.D., REUBIN ANDRES, M.D.THOMAS POZEFSKY, M.D., JOEL L. COLKER, M.D., HAROLD M. LANGS, M.D., REUBIN ANDRES, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-988 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt any given time there exists a group of individuals who, although reacting normally to standard tests of glucose tolerance, are destined to become overt diabetics in the future. The development of abnormal glucose tolerance in a sense represents a late stage in the natural history of diabetes. The ability to detect the diabetic diathesis at a stage of the disease before the development of grossly abnormal glucose tolerance would be of great theoretical interest and potentially of practical importance as well. The introduction of the cortisone-glucose tolerance test by Fajans and Conn (1) 11 years ago for the purpose...References1. FAJANSCONN SSJW: An approach to the prediction of diabetes mellitus by modification of the glucose tolerance test with cortisone. Diabetes 3: 296, 1954. CrossrefMedlineGoogle Scholar2. CONNFAJANS JWSS: The prediabetic state. A concept of dynamic resistance to a genetic diabetogenic influence. Amer. J. Med. 31: 839, 1961. CrossrefMedlineGoogle Scholar3. WEST KM: Comparison of the hyperglycemic effects of glucocorticoids in human beings. The effect of heredity on responses to glucocorticoids. Diabetes 6: 168, 1957. CrossrefMedlineGoogle Scholar4. SANDERS MJ: The effect of prednisolone on glucose tolerance in respect to age and family history of diabetes mellitus. Diabetes 10: 41, 1961. CrossrefMedlineGoogle Scholar5. GOTOKATOTAKANAMIOHNEDA YJAA: Detection of prediabetes by glucose-tolerance test sensitised by prednisolone. Lancet 2: 461, 1960. CrossrefMedlineGoogle Scholar6. LAMBERTJOHNSONPAUL THRBGR: Glucose and cortisone-glucose tolerance in normal and "prediabetic humans. Ann. Intern. Med. 54: 916, 1961. LinkGoogle Scholar7. WAJCHENBERGPUPOQUINTAOLEONSALDANHA BLAAERNPH: Predisposition to diabetes as evaluated by the cortisone-glucose tolerance test in children. Diabetes 13: 569, 1964. CrossrefMedlineGoogle Scholar8. DUNCAN LJ: Cortisone induced impairment of glucose tolerance in the detection of the diabetic diathesis. Quart. J. Exp. Physiol. 41: 453, 1956. CrossrefGoogle Scholar9. JACKSON WP: The cortisone-glucose tolerance test with special reference to the prediction of diabetes. Diagnosis of prediabetes. Diabetes 10: 33, 1961. CrossrefMedlineGoogle Scholar10. KYLEYALCINDREWYERCARRUTHER GCSRB: The prednisolone-glucose tolerance test in pregnancy. Diabetes 13: 572, 1964. CrossrefMedlineGoogle Scholar11. REAVENCALCIANOCODYLUCASMILLER GARCR: Carbohydrate intolerance and hyperlipemia in patients with myocardial infarction without known diabetes mellitus. J. Clin. Endocr. 23: 1013, 1963. CrossrefGoogle Scholar12. DAYSOGDOBSONBRENNAN AHLJC: Renal glomerular and vascular lesions in prediabetes and in diabetes mellitus: a study based on renal biopsies. Ann. Intern. Med. 54: 672, 1961. LinkGoogle Scholar13. VALLANCE-OWENLILLEY JMD: Insulin antagonism in the plasma of obese diabetics and prediabetics. Lancet 1: 806, 1961. CrossrefMedlineGoogle Scholar14. SCHNEEBERGFinestone NGI: The effect of age on the intravenous glucose tolerance test. J. Geront. 7: 54, 1952. CrossrefMedlineGoogle Scholar15. PETRIEMCLOUGHLINHODGINS LMCJTE: Mass screening for lowered glucose tolerance. Ann. Intern. Med. 40: 963, 1954. LinkGoogle Scholar16. SILVERSTONEBRANDFONBRENERSHOCKYIENGST FAMNWMJ: Age differences in the intravenous glucose tests and the response to insulin. J. Clin. Invest. 35: 504, 1956. Google Scholar17. Glucose Tolerance of Adults, United States, 1960-1962. PHS Publication no. 1000, series 11, no. 2, U. S. Government Printing Office, Washington, D. C., 1964, p. 25. Google Scholar18. BRANDT RL: Decreased carbohydrate tolerance in elderly patients. Geriatrics 15: 315, 1960. MedlineGoogle Scholar19. KLIMTWOLFFSILVERMANCONANT CRFWCJ: Calibration of a simplified cortisone glucose tolerance test. Diabetes 10: 351, 1961. CrossrefMedlineGoogle Scholar20. FAJANSCONN SSJW: Comments on the cortisone-glucose tolerance test. Ibid., p. 63. Google Scholar21. KNUTTI RE: The youthful science of aging. Today's Health 42: 16, 1964. Google Scholar22. SOMOGYI M: Determination of blood sugar. J. Biol. Chem. 160: 69, 1945. CrossrefGoogle Scholar23. New weight standards for men and women. Statist. Bull. Metrop. Life Insur. Co. 40: 1, 1959. Google Scholar24. IRVINGWANG EMI: Effect of previous diet on glucose tolerance tests. Glasgow Med. J. 35: 275, 1954. MedlineGoogle Scholar25. UNGER RH: The standard two-hour oral glucose tolerance test in the diagnosis of diabetes mellitus in subjects without fasting hyperglycemia. Ann. Intern. Med. 47: 1138, 1957. LinkGoogle Scholar26. WILKERSONBUTLERFRANCIS HLFKJO: The effect of prior carbohydrate intake on the oral glucose tolerance test. Diabetes 9: 386, 1960. CrossrefMedlineGoogle Scholar27. WILKERSONHYMANKAUFMANMCCUISTIONFRANCIS HLHMACJO: Diagnostic evaluation of oral glucose tolerance tests in nondiabetic subjects after various levels of carbohydrate intake. New Eng. J. Med. 262: 1047, 1960. CrossrefMedlineGoogle Scholar28. WEST KM: Response of the blood glucose to glucocorticoids in man. Diabetes 8: 22, 1959. CrossrefMedlineGoogle Scholar29. BURNSENGELVIAUSCOTTHOLLINGSWORTHWERK TWFLAJLDRE: Studies on the interdependent effects of stress and the adrenal cortex on carbohydrate metabolism in man. J. Clin. Invest. 32: 781, 1953. CrossrefMedlineGoogle Scholar30. SMITHSHOCK LENW: Intravenous glucose tolerance test in aged males. J. Geront. 4: 27, 1949. CrossrefMedlineGoogle Scholar31. ANDRESLANGS RHM: Unpublished observations. Google Scholar32. MOSENTHALBARRY HOE: Criteria for interpretation of normal glucose tolerance tests. Ann. Intern. Med. 33: 1175, 1950. LinkGoogle Scholar33. WILLIAMS RH: The pancreas, in Textbook of Endocrinology, 3rd ed., edited by WILLIAMS, R. H. W. B. Saunders Co., Philadelphia, 1962, p. 619. Google Scholar34. WILKERSONKRALL HLLP: Diabetes in a New England town. JAMA 135: 209, 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, MarylandFrom the Gerontology Branch, National Heart Institute, National Institutes of Health, Bethesda, Md., and the Baltimore City Hospitals, Baltimore, Md.Requests for reprints should be addressed to Reubin Andres, M.D., Gerontology Branch, National Heart Institute, Baltimore City Hospitals, Baltimore, Md. 21224. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIs the prevalence of dehydration among community-dwelling older adults really low? 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