tbuckley/cabot-search huggingface dataset:
Parasympathetic Denervation of the Iris in Uremia
Authors: Juan C. Idiaguez
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 December 1988Parasympathetic Denervation of the Iris in UremiaJuan C. Idiaguez, MD, Roberto O. García-Ortez, MD, Rodrigo K. Alonso, MDJuan C. Idiaguez, MDSearch for more papers by this author, Roberto O. García-Ortez, MDSearch for more papers by this author, Rodrigo K. Alonso, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-11-929_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Fraser and colleagues (1) have reported autonomic dysfunction in uremia. Parasympathetic pupillary denervation, however, was not mentioned. Because widespread autonomic neuropathy, which includes parasympathetic pupillary denervation (2), also occurs in patients with diabetes mellitus, a similar compromise is possible in patients with uremia. In 45 uremic patients and 33 controls (subjects at risk for autonomic neuropathy, such as persons with diabetes, alcoholism, and amyloidosis, were excluded), the supersensitivity to diluted pilocarpine (0.0625%) (3) was assessed. Two drops were instilled in one conjunctival sac in each patient, and the diameter of the pupil was measured on Polaroid camera...References1. FraserArieff CA. Nervous system complications in uremia. Ann Intern Med. 1988;109:143-53. LinkGoogle Scholar2. SigsbeeTorkelsonKadisWrigthReeves BRGJA. Parasympathetic denervation of the iris in diabetes mellitus. J Neurol Neurosurg Psychiatry. 1974;37:1031-5. CrossrefGoogle Scholar3. CohenZakov DZ. The diagnosis of Adie's pupil using 0.0625% pilocarpine solution. Am J Opthalmol. 1975;79:883-5. CrossrefMedlineGoogle Scholar4. RodriguesEwing ED. Immediate heart rate response to lying down: simple test for cardiac parasympathetic damage in diabetics. Br Med J. 1983;287:800. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Valparaiso Valparaiso Chile PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDisorders of the pupilParasympathetic denervation of the iris in Chagas' diseaseCorrection: Parasympathetic Denervation of the Iris in UremiaJuan C. Idiaquez, MD, Roberto O. García Ortiz, MD, Rodrigo K. Alonso, MD 1 December 1988Volume 109, Issue 11Page: 929-929KeywordsAlcoholismAmyloidosisDenervationDiabetes mellitusNeuropathy Issue Published: 1 December 1988 PDF DownloadLoading ...
Low-dose oral chloroquine in the treatment of porphyria cutanea tarda
Authors: R.E. ASHTON, J.L.M. HAWK, I.A. MAGNUS
Journal: British Journal of Dermatology (1984)

Journal Article Low‐dose oral chloroquine in the treatment of porphyria cutanea tarda Get access R.E. ASHTON, R.E. ASHTON Department of Photobiology, Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London E9 6BX, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.L.M. HAWK, J.L.M. HAWK Department of Photobiology, Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London E9 6BX, U.K. Search for other works by this author on: Oxford Academic Google Scholar I.A. MAGNUS I.A. MAGNUS Department of Photobiology, Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London E9 6BX, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue 5, 1 November 1984, Pages 609–613, https://doi.org/10.1111/j.1365-2133.1984.tb06632.x Published: 01 November 1984 Article history Accepted: 18 April 1984 Published: 01 November 1984
Iron in Bread
Authors: Louis Lasagna
Journal: JAMA (1975)

<h3>To the Editor.—</h3> A recent article inThe Journalby Dr. William H. Crosby (228:1651, 1974) raised about six points, as I remember, that represent important accusations about the Food and Drug Administration (FDA). If Crosby is correct, then the situation is shameful. If he is incorrect, then he is doing the FDA a great disservice. I would hope that Crosby could be invited to document such charges as "fraudulent chronology," etc.
TREATMENT OF INGROWING TOENAIL.
Authors: GERALD B. WEBB
Journal: JAMA (1907)

Some years ago I published<sup>1</sup>a method of treating ingrowing toenail by the use of silver wire. Latterly I have made a few changes in the technic which simplify the method for those who found difficulty in the mechanical adjustment of the wire. Instead of the annealed silver wire of pin size, I now take surgeon's silver suture wire, No. 26 (occasionally larger or smaller, depending on the case), and twist it, as shown in Figure 1, to get the effect of a piece of string. This can now be easily, manipulated to fit the toe without the need of pliers or artery forceps. Having molded it to fit accurately under the nail and around the edges, as in Figure 3, a piece of adhesive plaster is laid on the toe (Fig. 2), the wire reapplied and kept in position by straps of adhesive plaster run around, as in
Pathway activation patterns in diffuse large B-cell lymphomas
Authors: S Bentink, S Wessendorf, C Schwaenen, M Rosolowski, W Klapper, A Rosenwald, G Ott, A H Banham, H Berger, A C Feller, M-L Hansmann, D Hasenclever, M Hummel, D Lenze, P Möller, B Stuerzenhofecker, M Loeffler, L Truemper, H Stein, R Siebert, R Spang
Journal: Leukemia (2008)
Lettsomian Lectures on the Pathology and Treatment of Some Diseases of the Liver
Authors: S. O. Habershon
Journal: BMJ (1872)

THE liver and the bile are frequently regarded by unprofessional minds as inimical to the healthy working of man's organism.Like friends unjustly maligned, who are made to bear their own faults as well as their neighbours', scarcely anything too bad can be said of them by some persons, whilst they are really constant benefactors; and there is truth in the remark, that even in medical diagnosis the liver is often "the refuge for the destitute".[After describing the composition of the bile and the arrangement of the ducts, the lecturer proceeded to consider some of their pathological conditions.]Sjyasmzodic Occlusiont of the Bile-Dutcts.-Althoughno definite mus- cular coat can be traced in the bile-ducts, still they possess contractile bands, which1 are susceptible of irregular action.They receive nervous supply from the same source as the pylorus and the first portion of the duodenum, and in cases of gall-stone they are thrown into violent con- traction ; in catarrhal states of the mucous membrane the irritability is increased, but spasmodic contraction takes place independently of these causes.
Transthoracic ventricular defibrillation in the dog with unidirectional rectangular double pulses
Authors: J. C. Schuder, H. Stoeckle, P. Y. Keskar, J. H. Gold, M. T. Chier, J. A. West
Journal: Cardiovascular Research (1970)

Journal Article Transthoracic ventricular defibrillation in the dog with unidirectional rectangular double pulses Get access John C. Schuder, John C. Schuder From the Section of Thoracic and Cardiovascular Surgery, Department of Surgery, and Department of Pediatrics, University of Missouri, Columbia, Missouri 65201, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Harry Stoeckle, Harry Stoeckle From the Section of Thoracic and Cardiovascular Surgery, Department of Surgery, and Department of Pediatrics, University of Missouri, Columbia, Missouri 65201, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Prabhakar Y. Keskar, Prabhakar Y. Keskar From the Section of Thoracic and Cardiovascular Surgery, Department of Surgery, and Department of Pediatrics, University of Missouri, Columbia, Missouri 65201, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jerry H. Gold, Jerry H. Gold From the Section of Thoracic and Cardiovascular Surgery, Department of Surgery, and Department of Pediatrics, University of Missouri, Columbia, Missouri 65201, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael T. Chier, Michael T. Chier From the Section of Thoracic and Cardiovascular Surgery, Department of Surgery, and Department of Pediatrics, University of Missouri, Columbia, Missouri 65201, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Joe A. West Joe A. West From the Section of Thoracic and Cardiovascular Surgery, Department of Surgery, and Department of Pediatrics, University of Missouri, Columbia, Missouri 65201, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 4, Issue 4, October 1970, Pages 497–501, https://doi.org/10.1093/cvr/4.4.497 Published: 01 October 1970 Article history Accepted: 27 February 1970 Published: 01 October 1970
Care for Dementia
Authors: REMIGIO VICTOR BOCCIO
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 September 1981Care for DementiaREMIGIO VICTOR BOCCIO, M.D.REMIGIO VICTOR BOCCIO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-3-391_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: As a resident in internal medicine, I found the article by Cassel and Jameton (1) especially pertinent. Dementia is, indeed, one of the commoner problems I deal with and yet one of the most poorly understood and most neglected.The authors suggest three reasons why more attention is not given the demented patient. In my experience, the "institutional obstacles" referred to are the most difficult to deal with as they are often outside the sphere of influence of physicians (especially housestaff, who may be the greatest offenders in neglect of the demented patient). Although I agree that...Reference1. CASSELJAMETON CA. Dementia in the elderly: an analysis of medical responsibility. Ann Intern Med. 1981;94:802-7. LinkGoogle Scholar1. CASSELJAMETON CA. Dementia in the elderly: an analysis of medical responsibility. Ann Intern Med. 1981; 94:802-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Wayne State University Affiliated Hospitals Detroit, MI 48201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGeriatric MedicineROBERT L. DICKMAN, M.D. 1 September 1981Volume 95, Issue 3Page: 391-391KeywordsDementia Issue Published: 1 September 1981 PDF DownloadLoading ...
Patient Protection in Cancer Chemotherapy
Authors: Stanley A. Schwartz
Journal: JAMA (1966)

Eight patients undergoing intensive cancer chemotherapy have been treated in a protection unit. The antibiotic protocol in this program was designed to prevent the appearance of resistant organisms. The preliminary results indicate that it is quite feasible and practical to maintain an individual in a relatively germ-free environment for long periods of time. In this small group of patients there was no evidence of infection with the more common pathogens, despite severe bone marrow depression and leukopenia induced by antitumor agents.
Using lasers to image the retina
Authors: J. E Morgan
Journal: BMJ (1999)

High quality ophthalmic care depends on the accurate assessment of ocular disease. Conventional direct ophthalmoscopy is used widely and provides good two dimensional views of the retina. However, the true nature of retinal disease is apparent only in three dimensions. In diabetic maculopathy, direct ophthalmoscopy can reveal retinal exudates, but the degree of macula oedema, which usually underlies the decision to treat by laser photocoagulation,1 is less clear. In glaucoma, the earliest damage can be seen as thinning of the retinal nerve fibre layer with increased cupping of the optic disc.2 These changes are best viewed stereoscopically. In both cases, disease of the retinal or optic nerve head will change the surface contour of the retina, either elevating or depressing the retinal surface by up to several hundred micrometres. Clearly, the objective quantification of these changes would be of immense benefit in diagnosing disease and monitoring disease progression and response to treatment. 

#### Summary points

In diseases such as diabetic maculopathy and glaucoma changes in retinal structure precede visual symptoms

Earlier detection of these changes allows early intervention and improves the prognosis

Scanning laser ophthalmoscopes provide rapidly acquired views of the retina that enable the detection of these early changes

Clinical studies have shown the value of these devices in the diagnosis of glaucoma and diabetic maculopathy

The costs of these devices is falling and serious consideration should be given to their introduction into hospital based eye services

The three dimensional imaging of the retina has been facilitated by two technical developments. The first is the availability of cheap and powerful computers. The second is the production of affordable optoelectronics such as digital cameras and diode lasers. The incorporation of some of these technologies into clinical practice has been relatively straightforward and will be familiar to doctors in other specialties. For …
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Authors: Kitt Falk Petersen, Sylvie Dufour, Douglas Befroy, Rina Garcia, Gerald I. Shulman
Journal: New England Journal of Medicine (2004)

Insulin resistance appears to be the best predictor of the development of diabetes in the children of patients with type 2 diabetes, but the mechanism responsible is unknown.We performed hyperinsulinemic-euglycemic clamp studies in combination with infusions of [6,6-(2)H(2)]glucose in healthy, young, lean, insulin-resistant offspring of patients with type 2 diabetes and insulin-sensitive control subjects matched for age, height, weight, and physical activity to assess the sensitivity of liver and muscle to insulin. Proton ((1)H) magnetic resonance spectroscopy studies were performed to measure intramyocellular lipid and intrahepatic triglyceride content. Rates of whole-body and subcutaneous fat lipolysis were assessed by measuring the rates of [(2)H(5)]glycerol turnover in combination with microdialysis measurements of glycerol release from subcutaneous fat. We performed (31)P magnetic resonance spectroscopy studies to assess the rates of mitochondrial oxidative-phosphorylation activity in muscle.The insulin-stimulated rate of glucose uptake by muscle was approximately 60 percent lower in the insulin-resistant subjects than in the insulin-sensitive control subjects (P<0.001) and was associated with an increase of approximately 80 percent in the intramyocellular lipid content (P=0.005). This increase in intramyocellular lipid content was most likely attributable to mitochondrial dysfunction, as reflected by a reduction of approximately 30 percent in mitochondrial phosphorylation (P=0.01 for the comparison with controls), since there were no significant differences in systemic or localized rates of lipolysis or plasma concentrations of tumor necrosis factor alpha, interleukin-6, resistin, or adiponectin.These data support the hypothesis that insulin resistance in the skeletal muscle of insulin-resistant offspring of patients with type 2 diabetes is associated with dysregulation of intramyocellular fatty acid metabolism, possibly because of an inherited defect in mitochondrial oxidative phosphorylation.
THE PREPARATION AND SOME PROPERTIES OF PURIFIED ANTIBODY SPECIFIC FOR THE 2,4-DINITROPHENYL GROUP
Authors: Fuad S. Farah, Milton Kern, Herman N. Eisen
Journal: The Journal of Experimental Medicine (1960)

Injection of rabbits with Freund's complete adjuvant containing bovine γ-globulin substituted to near saturation with dinitrophenyl groups leads to the production of large amounts of antibodies specific for the 2,4-dinitrophenyl substituent. These antibodies can be isolated from sera in satisfactory yield (40 per cent) and in a high state of purity (90 per cent specifically precipitable). Hapten dissolution, which was used to screen haptens for their potential usefulness as specific reagents in the purification procedure, provides a means for evaluating, in relative terms, antibody-hapten affinities (in competition with antigen).
Beyond the Purple Heart — Continuity of Care for the Wounded in Iraq
Authors: James B Peake
Journal: New England Journal of Medicine (2005)

You can hear the usual hum of the emergency room, and all the familiar beeps of monitors in the operating room provide a backdrop for medical teams boasting the usual collection of skills and following the typical team approach to injured patients. But beyond the generic hospital buzz, the background noises are unusual. The whoosh and explosion of incoming mortars and the loud whine of the turbo engines of Blackhawk helicopters bringing patients, often directly from the point of wounding, distinguish the military combat support hospitals and forward surgical teams in Iraq from the ERs and ORs back home. Different . . .
The genomic landscape of nasopharyngeal carcinoma
Authors: De-Chen Lin, Xuan Meng, Masaharu Hazawa, Yasunobu Nagata, Ana Maria Varela, Liang Xu, Yusuke Sato, Li-Zhen Liu, Ling-Wen Ding, Arjun Sharma, Boon Cher Goh, Soo Chin Lee, Bengt Fredrik Petersson, Feng Gang Yu, Paul Macary, Min Zin Oo, Chan Soh Ha, Henry Yang, Seishi Ogawa, Kwok Seng Loh, H Phillip Koeffler
Journal: Nature Genetics (2014)
Long-Term Survival of Patients With Chronic Obstructive Pulmonary Disease Undergoing Coronary Artery Bypass Surgery
Authors: Bruce J. Leavitt, Cathy S. Ross, Brian Spence, Stephen D. Surgenor, Elaine M. Olmstead, Robert A. Clough, David C. Charlesworth, Robert S. Kramer, Gerald T. O’Connor
Journal: Circulation (2006)

Background— Chronic obstructive pulmonary disease (COPD) is associated with increased in-hospital mortality in patients undergoing coronary artery bypass surgery (CABG). Long-term survival is less well understood. The present study examined the effect of COPD on survival after CABG. Methods and Results— We conducted a prospective study of 33 137 consecutive isolated CABG patients between 1992 and 2001 in northern New England. Records were linked to the National Death Index for long-term mortality data. Cox proportional hazards regression was used to calculate hazard ratios (HRs). Patients were stratified by: no comorbidities (none), COPD, COPD plus comorbidities, and other comorbidities with no COPD. There were 131 434 person years of follow-up and 5344 deaths. The overall incidence rate (deaths per 100 person years) was 4.1. By group, rates were: 2.1 (none), 4.0 (COPD alone), 5.5 (other), and 9.4 (COPD plus; log rank P &lt;0.001). After adjustment, survival with COPD alone was worse compared with none (HR, 1.8; 95% CI, 1.6 to 2.1; P &lt;0.001). Patients with other comorbidities compared with none had even worse survival (HR, 2.2; 95% CI, 2.1 to 2.4; P &lt;0.001). Patients with COPD plus other comorbidities compared with none had the worst long-term survival (HR, 3.6; 95% CI, 3.3 to 3.9; P &lt;0.001). Conclusions— Patients with only COPD had significantly reduced long-term survival compared with patient with no comorbidities. Patients with COPD and ≥1 other comorbidity had the worst survival rate when compared with all of the other groups.
Depressive States in the Soldier: Their Symptoms, Causation, and Prognosis
Authors: R. F. Tredgold
Journal: BMJ (1941)

Among the patients of a military hospital for psychotics the number of cases of depression appeared to be note- worthy.These cases were of many different types, they had been precipitated by a number of causes in various personalities, and their course varied.An attempt was therefore made (i) to differentiate the types; (ii) to analyse the factors in each case and to correlate them if possible; and (iii) to describe the course, and response to treatment, of the various cases.Differentiation of Types In 1926 began the considerable controversy in this country on the question of differentiation between psychoses and neuroses, which unfortunately still con- tinues.This had been provoked by Mapother (1926), who stated that the distinction had grown out of practical differ- ences and that he could find no other basis for it.This was hotly contested by many speakers, their protagonist being Ross (1926), who has since defined his views more concisely (1937), stressing the differentiation of anxiety states from depressive psychoses.In point of fact he does not mention depression as a symptom occurring in an anxiety state, but his distinction of the latter from the depressive psychosis is based on the extent of its depen- dence on environment, as well as on the absence of retardation and presence of insight.
Abstract IA20: A bad influence: ERG, AR, and prostate cell differentiation
Authors: Raymond A. Pagliarini
Journal: Cancer Research (2012)

Abstract Aberrant expression of oncogenic ETS transcription factors such as ERG (via the TMPRSS2:ERG fusion) plays a key role in the development of a significant fraction of prostate cancers. However, the underlying biology of ERG's function in prostate cancer is incompletely understood, with a growing number of potential effector pathways implicated. To better understand the “ERG pathway”, we have worked towards elucidating the mechanism of ERG function in prostate cancer using a variety of in vitro and in vivo models. We observe that potent ERG inhibition (using inducible shRNA constructs) inhibits the proliferation of TMPRSS2:ERG positive VCaP prostate cancer cells. A number of phenotypic findings in this model suggest that ERG knockdown causes growth arrest by inducing aspects of prostate cell differentiation. In particular, the most significant transcriptional response to ERG inhibition was an upregulation of Androgen Receptor (AR)-dependent genes expressed in normal prostate lumenal epithelium. We validated these findings in additional in vitro models, and showed that recruitment of ERG to AR target genes attenuates recruitment of AR, even when ERG and AR are not bound to adjacent regions of the target gene. From these findings, we hypothesize that the main role of ERG in prostate cancer is to prevent AR-mediated cell differentiation signals, while still allowing AR-dependent proliferation. We are currently working to further elucidate the mechanism of how ERG controls AR recruitment to its target genes; in particular, whether any ERG-interacting proteins with enzymatic function (i.e., “druggable pockets”) mediate this effect. We are also working to build more robust in vitro models of AR-dependent prostate cell differentiation, in order to better assess how perturbing ERG function, as well as the function of other signaling pathways, affects this biology. Citation Format: Raymond A. Pagliarini. A bad influence: ERG, AR, and prostate cell differentiation [abstract]. In: Proceedings of the AACR Special Conference on Advances in Prostate Cancer Research; 2012 Feb 6-9; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(4 Suppl):Abstract nr IA20.
Obliterative bronchiolitis and upper-zone pulmonary consolidation in rheumatoid arthritis.
Authors: B G McCann, G J Hart, T C Stokes, B D Harrison
Journal: Thorax (1983)

We report a patient with two of the rare intrapulmonary complications of rheumatoid disease.Necropsy showed that obliterative bronchiolitis was the cause of the bilateral upper-zone consolidation noted on the chest radiograph.