tbuckley/cabot-search huggingface dataset:
Landmark perspective: The significance of Dr Fantus' report
Authors: B. A. Myhre
Journal: JAMA (1984)

<h3>History of Previous Transfusion Therapy</h3> With the usual availability of adequate amounts and types of blood that we encounter today, it is hard to visualize the difficulty that faced physicians wishing to transfuse before World War II. The account by Louis Diamond<sup>1</sup>chronicles how between the years of 1667 and 1937, the major accent in transfusion therapy was direct transfusion from donor to recipient, usually using some type of arteriovenous anastomosis,<sup>2,3</sup>a pump for direct transfusion,<sup>4</sup>multiple syringes,<sup>5</sup>various stopcocksyringe devices,<sup>6</sup>or, occasionally, a paraffin-lined flask<sup>7</sup>to hold the blood temporarily. No anticoagulant was used, the blood was not stored, all transfusions required the immediate availability of the donor, and the donor had to be bled in the proximity of the patient (often in an operating room). For these reasons, almost all transfusions were elective and given for chronic loss or decreased production of
DNA content, ploidy level and number of nuclei in the human heart after myocardial infarction
Authors: G.W Herget, M Neuburger, R Plagwitz, C.P Adler
Journal: Cardiovascular Research (1997)

Cardiac hypertrophy due to a prolonged functional activity is associated with an increase of cell size and polyploidization of the myocyte nuclei. Myocardial infarction is characterized by loss of myocytes. Increased load and as a consequence hypertrophic growth of the surviving myocardium has to be expected. The aim of this study was to investigate the response of cardiomyocytes after infarction.Biochemical and cytophotometric analysis was performed on myocyte and connective tissue nuclei to determine whether the human heart after myocardial infarction is accompanied by an increase in the ploidy level, DNA content and in the number of nuclei. A total of 15 hearts obtained from autopsy material was studied, among them 8 after myocardial infarction. The number of nuclei was measured by indirect computation.We found a decrease of 4c and no significant difference of 2c nuclei in infarcted hearts. DNA ploidy level (> 8c) as well as the proportion of aneuploid myocyte nuclei were increased in infarcted hearts. DNA concentration and total DNA content were increased in the hearts after myocardial infarction. Numerical ratio of connective tissue nuclei/myocyte nuclei, total number of nuclei, number of myocyte nuclei and number of connective tissue nuclei were increased in infarcted hearts.Polyploidization and nuclear hyperplasia of myocytes may represent an adaptive response of the myocardium to an ischemic injury.
Lactoferrin binds to cell membrane DNA. Association of surface DNA with an enriched population of B cells and monocytes.
Authors: R M Bennett, J Davis, S Campbell, S Portnoff
Journal: Journal of Clinical Investigation (1983)

The binding of human 125I-labeled lactoferrin (LF) to a population of adherent mononuclear cells (ADMC) and nonrosetting lymphocytes (E-) was abolished by prior treatment of the cells with deoxyribonuclease (DNase), but not ribonuclease (RNase). When DNase-treated ADMC were incubated with exogenous DNA, the binding of 125I-LF was restored. Enzymatic digestion with other enzymes, trypsin, phospholipase D, and neuraminidase, did not significantly influence 125I-LF binding. Saturable binding of LF at 0 degrees C was demonstrated for both E- and ADMC, with equilibrium dissociated constants of 0.76 x 10(-6) M and 1.8 x 10(-6) M, respectively. E- cells bound 2.5 x 10(7) and ADMC bound 3.3 x 10(7) molecules of Lf at saturation. Cell membranes were isolated from ADMC, E- and E+ and reacted with 125I-labeled LF; significant binding was only seen with ADMC and E-. Prior treatment of the membranes with DNase abolished the binding. Immunofluorescence studies indicated that a population of ADMC and E-, but not E+, exhibited a peripheral staining pattern for LF. Prior treatment of ADMC and E- with DNase abolished the surface immunofluorescence. This study provides evidence that cell membrane DNA acts as a binding site for exogenous LF. This is a novel role for DNA that has not been previously reported. Furthermore, it points to a basic difference between E+ cells vs. ADMC and E- cells in respect to their possession of cell surface DNA.
Vascular endothelial growth factor concentrations in serum of patients with extensive slow-flow vascular malformations
Authors: S. Ferrero
Journal: British Journal of Dermatology (2010)

Journal Article Vascular endothelial growth factor concentrations in serum of patients with extensive slow‐flow vascular malformations Get access S. Ferrero S. Ferrero Department of Obstetrics and Gynecology, San Martino Hospital and University of Genoa, Largo Rosanna Benzi 1, 16132 Genoa, Italy E‐mail: dr@simoneferrero.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 5, 1 May 2010, Pages 1155–1156, https://doi.org/10.1111/j.1365-2133.2010.09690.x Published: 01 May 2010
Comparison of Delayed Imaging with Tc-99m PMT and Tc-99m DEIDA for Visualization of Hepatoma
Authors: Y HASEGAWA, S NAKANO, T HASHIZUME, A NOGUCHI, K IBUKA, H KASUGAI, J KOJIMA, S ISHIGAMI
Journal: Clinical Nuclear Medicine (1989)

Delayed imaging was performed after the intravenous administration of Tc–99m DEIDA and Tc–99m PMT in 18 patients with hepatocellular carcinoma. Using Tc–99m DEIDA imaging, sharp uptake by liver tumors was observed in four patients (22%), but the uptake was similar to that of the surrounding normal liver in eight patients (44%). Using Tc–99m PMT imaging, the uptake by the tumor was notable in ten patients (56%) and normal in two (11%). Tc–99m PMT and Tc–99m DEIDA were both concentrated in hepatocellular carcinomas, but the former showed intense uptakes more frequently, and thus Is suggested to be useful in the diagnosis of hepatocellular carcinoma.
THE TREATMENT OF CONGENITAL DACRYOCYSTITIS
Authors: LEWIS W. CRIGLER
Journal: JAMA (1923)

The term  dacryocystitis is a misnomer. The condition develops after birth, and not before, and is not a true inflammation of the sac wall, but an infection of the retained excretions from the conjunctival sac. The condition that predisposes to this postnatal infection, however, is congenital in the sense that there has been a delay in Nature's process of canalization of the lacrimal passageways. This is manifest in at least 95 per cent. of all cases by delayed opening into the inferior nasal wall.  We are indebted to Born, Legal, Kolliker, Ewetzky, Schaeffer and others for our knowledge concerning the embryologic development of the nasolacrimal passageways; but to Schaeffer, perhaps, belongs the credit of a more thorough study of the subject in the human embryo, commencing when the initial cells are laid down and continuing the study until it is complete at the end of gestation. From his investigations,
Accuracy of recall of back pain after delivery
Authors: C. Macarthur, A. Macarthur, S. Weeks
Journal: BMJ (1996)

The relation between epidural anaesthesia during labour and delivery and the subsequent development of back pain is unclear. While our recent prospective study showed no association,1 two retrospective surveys showed an increased risk of backache associated with epidural anaesthesia.2 3 The retrospective studies were conducted long after delivery (12 months to nine years) and response rates were poor (40% to 63%). One possible interpretation is response bias—that is, women who had received an epidural during labour and who later had backache were more likely to respond. Another possibility is recall bias—women given an epidural may have expected backache and therefore may have been more likely to recall it. We performed a follow up study to determine the accuracy of recall of back pain among women who did and did not …
Should recent dental treatment exclude potential blood donors?
Authors: A. Nouri, T. W. MacFarlane, D. MacKenzie, D. A. McGowan
Journal: BMJ (1989)

the patient denied vigorously that she had ingested either of these drugs, but thin layer chromatography of the patient's urine showed a peak corresponding to propranolol.By the time this result became available the patient had discharged herself.She did not attend for follow up and was not readmitted to this hospital.Her general practitioner reported a long history of personality disturbance and antisocial behaviour, including alcohol abuse, domestic violence, and child neglect; offers of psychiatric help had been refused.
Lead Poisoning in Scrap-Metal Workers
Authors: Frederick E. Zimmer
Journal: JAMA (1961)

DURING THE summer of 1959 an old railroad bridge over the Susquehanna River near Northumberland, Pa., was dismantled. Steel members of the bridge, heavily coated with layers of paint, were cut into 3-ft. lengths to facilitate their handling as scrap steel. The cutting was performed by men working about 3 ft. apart in open air on the river bank using propane-compressed air torches. While cutting the steel the men were enveloped in dense clouds of bluish smoke which appeared to rise from the paint. Within a week of coming on this job several of the men, and within five weeks all of the seven men who were examined, complained of gagging, nausea, anorexia, muscular weakness, generalized aching, and fatigability. Six of the men had griping abdominal pains. Five were troubled by severe constipation. Vomiting was prominent for a few days in two of the patients, and nausea was noted in
THE ENDURING PARTNERSHIP OF A NEOPLASTIC VIRUS AND CARCINOMA CELLS
Authors: John G. Kidd
Journal: The Journal of Experimental Medicine (1942)

The V2 carcinoma—a transplanted rabbit cancer derived originally from a virus-induced papilloma and carrying in masked or altered form the virus primarily responsible for it—was propagated in five successive groups of animals all previously hyperimmunized against the papilloma virus. The cancer grew as well in the hyperimmunized hosts as in normal animals implanted during the same months; and serological tests, made when the tumor was eventually returned to ordinary hosts, proved that the virus was still associated with the carcinoma cells: it had increased to the usual extent as the tumor grew in the hyperimmune animals. The continued increase of the neoplastic virus during propagation of the V2 carcinoma in hyperimmunized hosts contrasts sharply with the elimination of certain extraneous passenger viruses when the tumors they ride upon are grown in hosts previously immunized against them. The facts as a whole would seem to warrant a distinction between the enduring partnership of a neoplastic virus and carcinoma cells on the one hand and the casual association of passenger viruses with tumor cells on the other.
Delayed Urticarial and Anaphylactic Reactions to Red Meat: Age of Onset, Severity, and Immunology Among 353 Cases and 140 Controls
Authors: Scott P. Commins, Alexander J. Schuyler, Lisa J. Workman, Luis A. Matos, Saju S. Eapen, Charles J. Lane, Theo Rispens, Peter W. Heymann, Timothy F. Platts-Mills, Thomas A.E. Platts-Mills
Journal: Journal of Allergy and Clinical Immunology (2015)
Increased fibrinolytic activity in the intima of atheromatous coronary arteries: protection at a price
Authors: M J Underwood, D P D. Bono
Journal: Cardiovascular Research (1993)

Objective: The aim was to quantify and compare the fibrinolytic activity of normal blood vessels (saphenous vein, internal mammary artery, and aorta) and atheromatous arteries (coronary endarterectomy specimens). Methods: Fibrinolytic activity was measured by fibrin plate and colorimetric assays on fresh samples of coronary endarterectomy core, internal mammary artery, human aorta, and saphenous vein from patients undergoing coronary artery bypass surgery. Results: Fibrinolytic activity on fibrin plates ranked in the order endarterectomy cores > internal mammary artery > saphenous vein. The increased activity of endarterectomy cores was associated with an increased content of extractable tissue plasminogen activator and was suppressed by monoclonal antibody to tissue plasmogen activator. Paired comparisons of tissues from the same patients confirmed this increased activity in endarterectomy specimens relative to normal artery or vein. Urokinase activity was also increased in some endarterectomy specimens, but was more variable than tissue plasmogen activator. Conclusions: The increased fibrinolytic activity of endarterectomy cores may help preserve patency in atheromatous vessels, but at the possible price of increased intimal instability and fibrous proliferation. Cardiovascular Research 1993;27:882-885
Molecular Imaging of Endothelial Vascular Cell Adhesion Molecule-1 Expression and Inflammatory Cell Recruitment During Vasculogenesis and Ischemia-Mediated Arteriogenesis
Authors: Carolyn Z. Behm, Beat A. Kaufmann, Chad Carr, Miles Lankford, John M. Sanders, C. Edward Rose, Sanjiv Kaul, Jonathan R. Lindner
Journal: Circulation (2008)

Inflammatory responses contribute to vascular remodeling during tissue repair or ischemia. We hypothesized that inflammatory cell recruitment and endothelial cell activation during vasculogenesis and ischemia-mediated arteriogenesis could be temporally assessed by noninvasive molecular imaging.Contrast ultrasound perfusion imaging and molecular imaging with microbubbles targeted to activated neutrophils, alpha(5)-integrins, or vascular cell adhesion molecule (VCAM-1) were performed in murine models of vasculogenesis (subcutaneous matrigel) or hind-limb ischemia produced by arterial occlusion in wild-type or monocyte chemotactic protein-1-deficient mice. In subcutaneous matrigel plugs, perfusion advanced centripetally between days 3 and 10. On targeted imaging, signal enhancement from alpha(5)-integrins and VCAM-1 coincided with the earliest appearance of regional blood flow. Targeted imaging correlated temporally with histological evidence of channel formation by alpha(5)-integrin-positive monocytes, followed by the appearance of spindle-shaped cells lining the channels that expressed VCAM-1. In ischemic hind-limb tissue, skeletal muscle blood flow and arteriolar density increased progressively between days 2 and 21 after arterial ligation. Targeted imaging demonstrated early signal enhancement for neutrophils, monocyte alpha(5)-integrin, and VCAM-1 at day 2 when blood flow was very low (<20% control). The neutrophil signal declined precipitously between days 2 and 4, whereas VCAM-1 and monocyte signal persisted to day 7. In mice deficient for monocyte chemotactic protein-1, monocyte-targeted signal was severely reduced compared with wild-type mice (1.2+/-0.6 versus 10.5+/-8.8 video intensity units on day 4; P<0.05), although flow responses were only mildly impaired.Different components of the inflammatory response that participate in vascular development and remodeling can be assessed separately with targeted molecular imaging.
Unilateral Herpes Zoster Ophthalmicus Results in Bilateral Corneal Nerve Alteration
Authors: Pedram Hamrah, Andrea Cruzat, Mohammad H. Dastjerdi, Harald Prüss, Lixin Zheng, Bashar M. Shahatit, Hasan A. Bayhan, Reza Dana, Deborah Pavan-Langston
Journal: Ophthalmology (2012)
A Crossover Study Comparing Tc-99m-labeled HMDP and MDP in Patients
Authors: L ROSENTHALL, A ARZOUMANIAN, B DAMTEW, J TREMBLAY
Journal: Clinical Nuclear Medicine (1981)

ROSENTHALL, L M.D.; ARZOUMANIAN, A M.D.; DAMTEW, B M.D.; TREMBLAY, J R.T. (NM) Author Information
Sequelae of Cerebrospinal Meningitis
Authors: J. A. Degen, H. Cameron, V. L. M. Robinson, M. S. R. Wieden
Journal: BMJ (1945)

The present survey was designed primarily to answer a single question, "Is there an appreciable incidence of persistent symptoms following cerebrospinal meningitis, and, if so, what are the nature and the severity of these symptoms ?"The term "symptoms" is used advisedly, and refers to the sub- jective sensations and feelings of the patient as opposed to specific pathological states or conditions.The data here pre- sented are therefore based solely on the statements of the patients themselves.It would obviously be highly desirable to carry out a medical check-up as well, but lack of necessary facilities and of medical personnel unfortunately made such a procedure impossible.The area chosen for the survey comprised three geographically distinct districts.The chief of these was in south-east Wales and Monmouthshire, the lists of patients being supplied by two large city isolation hospitals (at Cardiff and Newport) and five smaller isolation hospitals in coal-mining towns of.southern Glamorganshire (Bridgend, Caerphilly, Gelligaer, Pontypridd, and Rhondda).Two smaller areas were added by way of contrast-the Denbighshire region served by the Wrexham Isolation Hospital, and the largely rural area from TABLE I Meningitis Cases Excluded from Series 0 " Hospital |o | i ,0.a 0~.d0 0-.
Prolonged Survival in Down's Syndrome
Authors: P. A. Cato
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The article by Charles H. McGowen, MD, (237:673, 1977) reporting a case of Down's syndrome as the oldest Down's syndrome patient (death at 65 years of age) will undoubtedly be challenged by those who have spent much time working in well-run residential care centers. As a physician employed by The Brown Schools (PO Box 4088, Austin, TX 78765), I have had an opportunity to supervise the care of a male Down's syndrome patient whose birthdate is Feb 28, 1908, making him 69 years old. He is still alive and now resides at a nearby nursing home. I suspect that many physicians have encountered older patients with Down's syndrome in this day and time.
Management of Patients with Bronchial Asthma, Elevated IgE and Eosinophilia Including Patients with Churg Strauss Syndrome
Authors: V.V. Chopyak, G.O. Potomkina, K.O. Lishchuk-Yakymovych, R.R. Holovyn, I.V. DuBuske, L.M. DuBuske
Journal: Journal of Allergy and Clinical Immunology (2007)
THE OPERATIVE TREATMENT OF ULCERATIVE COLITIS
Authors: P. Lockhart-Mummery
Journal: BMJ (1920)

ULCERATIVE COLITIS acht ind: no-vomiting, and no-complaint of difficulty in walkingi6r of giddiness.On examination the pupils were found to be unequal in size, the right being larger than the left; the right pupil reacted ,briskly to light and apcoinmodation; the left pupil was Gon- tracted, slightly irreqular in shape, and reacted only very sluggishly to light.there was no nystagmus and no ocular paralysis.The fundi were normal.With the exception of the deafness the functions of the other cranial nerves were not disturbed in any way.There was practically complete bilateral nerve deafness.He was examined by Mr. Muecke, who considered that the nerve conduction from the labyrinth was almost completely blocked on both sides, more so on
Active Compression-Decompression CPR
Authors: Alexander Mazziotti
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Dr Lurie and colleagues<sup>1</sup>conclude that active compression-decompression (ACD) cardiopulmonary resuscitation (CPR) appears to be more effective than standard CPR in certain subsets under study. This statistical inference is dependent on matching baseline characteristics as presented in their Table 1. In prehospital nontraumatic cardiac arrest, a sudden reversible cardiac miscue based on myocardial ischemia or a small myocardial infarction in an otherwise healthy person is the most likely condition to have a successful CPR outcome. On the other hand, if the pathway to arrest is pulmonary embolus, massive cerebral vascular accident, aortic dissection, or sepsis, then the probability of a successful outcome is much less. The authors match the previous cardiac history in both groups (62%); however, previous cardiac history alone, without the present clinical history, is not sufficient to give meaning to the statistical analysis. This is particularly true for the subgroup analysis of those
Vaccination against opportunistic infections in patients with inflammatory bowel disease on immunomodulator therapy
Authors: C. T. Tee, S. T. Peake, J. Landy, N. Arebi
Journal: Gut (2011)

<h3>Introduction</h3> Immunomodulators (IM) and biological agents are now used more often and earlier in Inflammatory Bowel Disease (IBD), leading to an increase in opportunistic infections (OI). The RR of OI is reported as OR of 2.9 with one IM, increasing to OR of 14.5 with ≥2 concomitant IMs. Age (&gt;50 years) is also an independent risk factor for OI. These vaccinations are recommended by the European Crohn9s and Colitis Organisation (ECCO) to minimise OI in immunocompromised IBD patients; Varicella Zoster Virus (VZV) (if no history of chickenpox/shingles and serology is negative), Human Papilloma Virus (HPV), annual Influenza (inactivated vaccine), Pneumococcal and Hepatitis B (if HBV seronegative). Following the Influenza A outbreak (H1N1) in 2009, Swine Flu vaccination was also recommended. The authors aimed to investigate the vaccination status of IBD patients on one or more IM. <h3>Methods</h3> The authors identified a cohort of 200 patients on IM or biological therapy from outpatients attendance between September 2009 and June 2010. Questionnaires were posted to the General Practitioners (GP) to obtain vaccination status for Flu (within 1 year), Pneumococcal (within last 5 years), VZV, HPV and Swine Flu. T test was used to examine for differences in higher risk groups. <h3>Results</h3> The response rate was 51.5% (103/200). Median age was 42 years (range 16–74); 54 were female (52.4%). 82 were tertiary referrals (79.6%). 75.7% had Crohn9s disease (n=78). IMs included Azathioprine (35.9%, n=37), 6-Mercaptopurine (9.7%, n=10), corticosteroids (5.8%, n=6), Methotrexate (3.8%, n=4) and Tacrolimus (1.9%, n=2). Biological agents included Infliximab (36.9%, n=38) and Adalimumab (25.2%, n=26). 21 patients were ≥50 years old; 47.6% (10/21) had received the Influenza and/or Swine Flu vaccination compared to 40.2% (33/82) in the younger age group (p=0.6). Of the 10 patients receiving dual IM and biological therapy, 9 (90%) received both annual Influenza and Swine Flu vaccinations (p&lt;0.001). <h3>Conclusion</h3> Majority of patients at risk of OI in this cohort are on biological therapy. Very few received the recommended vaccinations. Patients on dual immunosuppression had significantly higher vaccine uptake. These findings may be due to lack of awareness of the risks associated with immunosuppression. Information leaflets on the ECCO-recommended vaccines directed at GPs and patients may improve compliance.
Complete remission with bortezomib on plasmocytomas in an end-stage patient with refractory multiple myeloma who failed all other therapies including hematopoietic stem cell transplantation: possible enhancement of graft-vs-tumor effect
Authors: E Paubelle, P Coppo, L Garderet, L Azizi, D Bories, N-C Gorin, L Fouillard
Journal: Leukemia (2005)