Reversible Hepatic Veno-Occlusive Disease and 6-Thioguanine
Authors: N. KRIVOY
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 June 1982Reversible Hepatic Veno-Occlusive Disease and 6-ThioguanineN. KRIVOY, M.D., R. RAZ, M.D., A. CARTER, M.D., G. ALROY, M.D.N. KRIVOY, M.D.Search for more papers by this author, R. RAZ, M.D.Search for more papers by this author, A. CARTER, M.D.Search for more papers by this author, G. ALROY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-6-788_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the article by Gill and associates (1). We report another case of reversible veno-occlusive disease of the liver caused by 6-thioguanine in a patient with acute leukemia in remission who was concomitantly treated with methotrexate.A 46-year-old man was hospitalized in April 1976 for evaluation of acute diffuse abdominal pain, fever, and sudden ascites that began 1 week before admission. In January 1976 he had been started on 6-thioguanine, 120 mg/d, and methotrexate, 30 mg/week. One week before hospitalization a bone marrow aspiration was done that did not show leukemic activity. At the...References1. GILLONSTADCARDAMONEMANEVALSUMNER RGJDH. Hepatic veno-occlusive disease caused by 6-thioguanine. Ann Intern Med. 1982;96:58-60. LinkGoogle Scholar2. BRAS G. Aspects of hepatic vascular lesions. In: GALL EA, MOSTOFI K, eds. The Liver. Baltimore: Williams & Wilkins Co.; 1973: 412-30. Google Scholar3. MEINDOKLANGER HB. Liver scan in Budd-Chiari syndrome. J Nucl Med. 1976;17:365-8. MedlineGoogle Scholar4. GRINEREL BADAWIPACKMAN PAH. Veno-occlusive disease after chemotherapy of acute leukemia. Ann Intern Med. 1976;85:578-82. LinkGoogle Scholar5. MITCHELLLAUTERBURG JB. Drug induced liver injury. Hosp Prac. 1978;13:95-106. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rambam Medical Center Haifa Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTioguanineOral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trialDRUGS USED IN CANCER CHEMOTHERAPYPurine Synthesis Inhibitors, 6-thioguanine and Azathioprine: Forgotten Treatment Options in Psoriasis and Psoriatic ArthritisA systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel diseaseToxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trialHepatotoxicity of ChemotherapyVascular Toxicity of Antineoplastic AgentsTioguaninePortal hypertension develops in a subset of children with standard risk acute lymphoblastic leukemia treated with oral 6-thioguanine during maintenance therapyEarly Hepatic Nodular Hyperplasia and Submicroscopic Fibrosis Associated With 6-Thioguanine Therapy in Inflammatory Bowel Disease6-Thioguanine can cause serious liver injury in inflammatory bowel disease patients.Early Nodular Hyperplasia of the Liver Occurring With Inflammatory Bowel Diseases in Association With Thioguanine TherapyVeno-occlusive disease in patients receiving thiopurines during maintenance therapy for childhood acute lymphoblastic leukaemiaHepatotoxicity Associated With 6-Thioguanine Therapy for Crohn's DiseaseHepatotoxicity of ChemotherapyANTIMETABOLITES AND CYTOTOXIC DRUGSVENO-OCCLUSIVE DISEASE OF THE LIVER ASSOCIATED WITH THIOPURINES IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIACANCER CHEMOTHERAPY AND THE LIVERHEPATOTOXICITY OF CHEMOTHERAPEUTIC AND ONCOLOGIC AGENTS6-Thioguanine therapy for psoriasis causing toxic hepatic venoocclusive diseaseThioguanine used in maintenance therapy of chronic myeloid leukaemia causes non-cirrhotic portal hypertension. RESULTS FROM MRC CML II TRIAL COMPARING BUSULPHAN WITH BUSULPHAN AND THIOGUANINETREATMENT OF PSORIASIS WITH 6-THIOGUANINE12 Drug-induced vascular and sinusoidal lesions of the liverCytostatics and immunosuppressive drugs 1 June 1982Volume 96, Issue 6_Part_1Page: 788-788KeywordsAbdominal painAscitesBone marrowFeversHospitalizationsLiver diseasesMethotrexate Issue Published: 1 June 1982 PDF downloadLoading ...