Coronary Thrombosis
Authors: P. A. OWREN
Journal: Annals of Internal Medicine (1965)

Article1 August 1965Coronary ThrombosisIts Mechanism and Possible Prevention by Linolenic AcidP. A. OWREN, M.D.P. A. OWREN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-167 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe rapid increase in the prevalence of coronary heart disease (CHD) in recent decades has frightened the public, alarmed the health authorities, and challenged the medical profession. The fundamental lesion in more than 95% of all cases of CHD is coronary atherosclerosis. This is always a local manifestation of a generalized disease, a universal process that occurs in most humans. It begins in early childhood as fatty streaks and develops into progressive atheroma from the time of adolescence (Figure 1). In some individuals coronary atheroma remains clinically silent for a lifetime, but others are stricken by CHD because of complicating...References1. GERTLERWHITECADYWHITER MMPDLDHH: Coronary heart disease. A prospective study. Amer. J. Med. Sci. 248: 377, 1964. CrossrefMedlineGoogle Scholar2. KANNELDAWBERFRIEDMANGLENNONMCNAMARA WBTRGDWEPM: Risk factors in coronary heart disease. Ann. Intern. Med. 61: 888, 1964. LinkGoogle Scholar3. JERVELLMEYERWESTLUND AKK: Coronary heart disease and serum cholesterol in males in different parts of Norway. Acta Med. Scand. 177: 13, 1965. CrossrefMedlineGoogle Scholar4. RINZLERCHRISTAKISWINSLOWSTEPHANSONFRIEDMANFEINJAMESKRAUSARCHER SHGAJGHGAM: American Public Health Association Meeting, New York, October, 1964. Med. News 190: 31, 1965. Google Scholar5. DUGUID JB: Thrombosis as a factor in the pathogenesis of coronary arteriosclerosis. J. Path. Bact. 58: 207, 1946. CrossrefMedlineGoogle Scholar6. HAUSTMORE MDRH: The thrombotic basis of arteriosclerosis. The Heart Bull. 9: 90, 1960. MedlineGoogle Scholar7. MOREMOVATHAUST RHHZMD: The role of mural fibrin thrombi of the aorta in the genesis of arteriosclerotic plaques. Report of two cases. Arch. Path. (Chicago) 63: 612, 1957. MedlineGoogle Scholar8. CRAWFORD T: Some aspects of the pathology of coronary occlusion. Proceedings of the Royal College of Physicians. Pitman Medical Publishing Co. Ltd., London, 1959. Google Scholar9. MOREHAUST RHMD: The role of thrombosis in occlusive disease of coronary arteries, in Anticoagulants and Fibrinolysis. McMillan Cp., Toronto, 1961, p. 143. Google Scholar10. MUSTARDMURPHYROWSELLDOWNIE JFEAHCHG: Factors influencing thrombus formation in vivo. Amer. J. Med. 33: 621, 1962. CrossrefMedlineGoogle Scholar11. MUSTARDMURPHYROWSELLDOWNIE JFEAHCHG: Platelets and atherosclerosis. J. Atheroscler. Res. 4: 1, 1964. CrossrefMedlineGoogle Scholar12. BOUNAMEAUX Y: L'accolement des plaquettes aux sous endotheliales. C. R. Soc. Biol. 153: 865, 1959. MedlineGoogle Scholar13. HUGUES J: L'accolement des plaquettes aux structures conjonctives perivasculaires. Thromb. Diath. Haemorrh. 8: 241, 1962. MedlineGoogle Scholar14. ZUCKERBORELLI MBJ: Platelet clumping produced by connective tissue suspensions and by collagen. Proc. Soc. Exp. Biol. Med. 109: 779, 1962. CrossrefGoogle Scholar15. EBERTSCHIMMELBUSCH JCC: Experimentelle Untersuchungen über Thrombose. Fortschr. Med. 4: 115, 1886. Google Scholar16. OWREN PA: The mechanism of hemostasis, in Proceedings of the 8th Congress of the International Society of Blood Transfusion in Tokyo, 1960, Karger, Basel and New York, 1962, p. 1522. Google Scholar17. OWREN PA: Blood coagulation and spontaneous hemostasis, in Proceedings of the XXIIth International Congress of Physiologic Science, Leiden, The Netherlands, 1962, p. 233. Google Scholar18. BORCHGREVINKOWREN CFPA: The hemostatic effect of normal platelets in hemophilia and Factor V deficiency. Acta Med. Scand. 170: 375, 1961. CrossrefMedlineGoogle Scholar19. HELLEM AJ: Demonstration of a substance in red cells affecting the adhesiveness of blood platelets, in Proceedings of the VIIth International Congress of Hematology, Vol. 2, Rome, 1958. Google Scholar20. GAARDERJONSENLALANDHELLEMOWREN AJSAJPA: Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature (London) 192: 531, 1961. CrossrefMedlineGoogle Scholar21. SOKAL A: Personal communication. Google Scholar22. ØDEGAARDSKÅLHEGGHELLEM ABAAJ: ADP induced platelet adhesiveness as a diagnostic test in von Willebrand's disease. Thromb. Diath. Haemorrh. 11: 23, 1964. MedlineGoogle Scholar23. HOVIG T: Release of platelet aggregating substance (adenosine diphosphate) from rabbit blood platelets induced by saline extracts of tendons. Thromb. Diath. Haemorrh. 9: 264, 1963. Google Scholar24. HELLEM AJ: The adhesiveness of human blood platelets in vitro. Scand. J. Clin. Lab. Invest. 12: Suppl. 51, 1, 1960. MedlineGoogle Scholar25. ØDEGAARD A: Unpublished data. Google Scholar26. EGEBERG O: Blood coagulation and intravascular hemolysis. Scand. J. Clin. Lab. Invest. 14: 217, 1962. CrossrefMedlineGoogle Scholar27. EGEBERG O: Clotting factor levels in patients with coronary atherosclerosis. Ibid., p. 253. Google Scholar28. EGEBERG O: The effect of unspecific fever induction on the blood clotting system. Ibid., p. 471. Google Scholar29. EGEBERG O: Changes in the coagulation system following major surgical operations. Acta Med. Scand. 171: 679, 1962. CrossrefMedlineGoogle Scholar30. EGEBERG O: The blood coagulability in diabetic patients. Scand. J. Clin. Lab. Invest. 15: 533, 1963. CrossrefMedlineGoogle Scholar31. ØDEGAARD A: Unpublished data. Google Scholar32. CRAWFORDDEXTERTEARE TDRD: Coronary-artery pathology in sudden death from myocardial ischemia. A comparison by age-groups. Lancet i: 181, 1961. CrossrefGoogle Scholar33. BRANWOODMONTGOMERY AWGL: Observations on the morbid anatomy of coronary artery disease. Scot. Med. J. 1: 367, 1956. CrossrefMedlineGoogle Scholar34. STRONGMCGILL JPHC: The natural history of coronary atherosclerosis. Amer. J. Path. 40: 37, 1962. MedlineGoogle Scholar35. DEDICHENSTRØMADELSTEN-JENSENCLOSS JARK: Incidence of atherosclerotic disease during war years, in Transactions of the 5th Conference on Factors Regulating Blood Pressure, Josiah Macy, Jr. Foundation, New York, 1951, p. 117. Google Scholar36. NORDØY A: The influence of saturated fats, cholesterol, corn oil and linseed oil on experimental venous thrombosis in rats. Thromb. Diath. Haemorrh. 13: 244, 1965. MedlineGoogle Scholar37. NORDØY A: The influence of saturated fat, cholesterol, corn oil and linseed oil on the ADP-induced platelet adhesiveness in the rat. Ibid., p. 543. Google Scholar38. STRØM A: Examination into the diet of Norwegian families during the war years 1942-45. Acta Med. Scand. 81: Suppl. 214, 1948. Google Scholar39. NOTEVARP O: Umettede fettsyrer i vår ernaering og i blodet. T. Kjemi, Bergv. Metallurgy. 20: 187, 1960. Google Scholar40. NOTEVARPCYVIN OBN: Polyunsaturated fatty acids in fish fat, in the diet and in the blood, in Fish in Nutrition: Lipids and Fish Oils. Fishing News (Books) Lt., London, 1962. Google Scholar41. NESTRØGSTADØGRIM IKME: Kostholdsundersøkelser i Lom og Skjåk. Landsforeningen for kosthold og helse, Oslo, 1964. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: P. A. OWREN, M.D.Affiliations: Oslo, NorwayFrom the University Hospital of Oslo, Norway.Presented at the Golden Anniversary Session of the American College of Physicians, Chicago, Ill., March 24, 1965.Requests for reprints should be addressed to P. A. Owren, M.D., Rikshospitalet, Medisinsk Avdeling A, Universitetsklinikk, Oslo, Norway. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffect of Fruit and Vegetable Intake on cvd Risk Factors in HumansAliphatic Carboxylic Acids: UnsaturatedHeart AttackAutonomic Function, Omega-3, and Cardiovascular RiskDiet and risk of ischemic heart disease in IndiaRelation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study,,Aliphatic Carboxylic Acids, UnsaturatedDietary intake of α-linolenic acid and risk of fatal ischemic heart disease among womenDietary fatty acids in human thrombosis and hemostasisThe combined role of atheroma, cholesterol, platelets, the endothelium and fibrin in heart attacks and strokesMARGARINE (NOT BUTTER) THE CULPRIT?ISCHAEMIC HEART DISEASE MORTALITYUnsaturated fatty acids and platelet aggregation: In vitro studyThe beriberi analogy to myocardial infarctionThe dominant diseases of modernized societies as omega-3 essential fatty acid deficiency syndrome: Substrate beriberiThe protective effects of dietary fish oil on focal cerebral infarctionInhibition of prostaglandin biosynthesis by eicosapentaenoic acidPrognostic Value of Blood Platelet Counts, Coagulation Factors and Serum Fibrin/Fibrinogen Degradation Products (FDP) in Acute InfectionsThe Effects of Lipids and Fatty Acids on Blood Coagulation and Platelets in Relation to ThrombosisProphylaxis of Postoperative Venous Thrombosis by Combined Leg Bandaging and Oxyphenbutazone Clinical and Experimental InvestigationsThe effect of O-(β-hydroxyethyl) rutoside on platelet intermediary metabolism in normal and streptozotocin diabetic ratsThe Occurrence and Significance of Fibrin/Fibrinogen Degradation Products (FDP) in Acute InfectionsA study of the effect of an oral contraceptive on blood coagulation factors, platelets and fibrinolytic activityPlatelets in shock and traumaPlatelet adhesiveness and aggregation in relation to diabetic retinopathyLow Fibrinolytic Activity of Blood and Vein Walls in Venous ThrombosisBiological activities of and requirements for polyunsaturated acidsPlatelet adhesiveness, plasma fibrinogen and factor VIII levels in diabetes mellitusThe effect of ethanol on human platelet aggregation In vitroStudies of platelet adhesiveness, blood viscosity and the microcirculation in patients with thrombotic diseaseThromboembolism of Leg following Percutaneous Catheterisation of Femoral Artery for AngiographyREFERENCESThe effect of “in-vivo” alteration of free fatty acids on platelet stickinessARGININE INFUSION IN MATURITY-ONSET DIABETES MELLITUSRELATIONSHIP BETWEEN POSTOPERATIVE CHANGES IN ADENOSINE-DIPHOSPHATE INDUCED PLATELET ADHESIVENESS AND VENOUS THROMBOSISOccurrence of Arteriosclerosis in von Willebrand's DiseaseChapter 16. AtherosclerosisLINOLENIC ACID AND CORONARY THROMBOSISP. A. OWREN, M.D.PSEUDOMOSAICISM IN MALES WITH MILD GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCYLINOLENIC ACID AND PLATELET ADHESIVENESS 1 August 1965Volume 63, Issue 2Page: 167-184KeywordsAtheromasAtherosclerosisCongenital heart diseaseCoronary heart diseaseFamilial hypercholesterolemiaIngestionLesionsPrevention, policy, and public healthStable coronary artery diseaseThrombosis ePublished: 1 December 2008 Issue Published: 1 August 1965 Copyright & PermissionsCopyright ©, 1965, by The American College of PhysiciansPDF downloadLoading ...