tbuckley/cabot-search huggingface dataset:
Injury, Death, and Cholesterol
Authors: Matthew F. Muldoon
Journal: Annals of Internal Medicine (1994)

Letters1 November 1994Injury, Death, and CholesterolMatthew F. Muldoon, MDMatthew F. Muldoon, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-9-199411010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In 1990, my colleagues and I reported that the mortality outcomes in randomized, primary prevention trials of cholesterol-lowering measures, when aggregated with the results of a meta-analysis, showed an excess of suicide and traumatic deaths (that is, “non-illness mortality”) in the treated men (odds ratio, 1.76; P = 0.004) [1]. Cummings and Psaty [2] examined this issue by analyzing non-illness mortality occurring in multiple risk factor intervention trials; however, these trials, by their design, preclude attributing any outcome to one particular intervention.Cummings and Psaty also redid the meta-analysis of the primary prevention trials of non-illness mortality ...References1. Muldoon MF, Manuck SM, Matthews KM. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. BMJ. 1990; 301:309-14. Google Scholar2. Cummings P, Psaty BM. The association between cholesterol and death from injury. Ann Intern Med. 1994; 120:848-55. Google Scholar3. Tobert JA. The cholesterol controversy (Letter). BMJ. 1992; 304:713. Google Scholar4. Muldoon MF, Rossouw JE, Manuck SB, Glueck CJ, Kaplan JR, Kaufmann PG. Low or lowered cholesterol and risk of death from suicide and trauma. Metabolism. 1993; 42(Suppl 1):45-56. Google Scholar Author, Article, and Disclosure InformationAuthors: Matthew F. Muldoon, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAtorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic miceSimvastatin prevents and ameliorates depressive behaviors via neuroinflammatory regulation in miceStatins use and risk of depression: A systematic review and meta-analysisSimvastatin Causes Changes in Affective Processes in Elderly VolunteersLong-term statin use and psychological well-beingEffects of lovastatin on cognitive function and psychological well-being∗∗Access the “Journal Club” discussion of this paper at http://www.elsevier.com/locate/ajmselect/ 1 November 1994Volume 121, Issue 9Page: 719-720KeywordsCardiovascular therapyCholesterolClinical trial reportingGlobal healthIntent to treat analysisMedical risk factorsMortalityOdds ratioRandomized trialsSuicide ePublished: 15 August 2000 Issue Published: 1 November 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Gallstones: Laparoscopic Treatment, Intracorporeal Lithotripsy Followed by Cholecystostomy or Cholecystectomy - A Personal Technique
Authors: J. Perissat, D. R. Collet, R. Belliard
Journal: Endoscopy (1989)

See also: Successful Treatment of Bile Duct Injury Inflicted during Laparoscopic Cholecystectomy by Endoscopic Retrograde Biliary DrainageEndoscopy 1992; 24(09): 801-801DOI: 10.1055/s-2007-1010590
Depression and Oral Contraception
Authors: K. L. Oldershaw
Journal: BMJ (1970)

BRjTisHShe was para 3 + 0. The second was a twin pregnancy.All four children were alive and well.Her last menstrual period was on 6 July 1968.The uterine size was compatible with the period of gestation.On 22 October 1968 hysterotomy and Pameroy sterilization was performed by an experienced member of our team.A single fetus was removed from the uterine cavity, and the postoperative period was satisfactory apart from mild urinary tract infection.At the follow-up clinic on 27 December 1968 the patient presented with a uterus the size of a 24-week gestation.She was obviously pregnant and she was booked for a hospital delivery.On
Amyloidosis and systemic lupus erythematosus.
Authors: M G Ridley, P J Maddison, C R Tribe
Journal: Annals of the Rheumatic Diseases (1984)

A patient with systemic lupus erythematosus who developed reactive amyloidosis associated with high levels of serum amyloid-A protein (SAA) is reported. The possible relevance of elevated SAA levels in the aetiology of amyloidosis is discussed.
A MEMORABLE PATIENT
Authors: R. Barnes
Journal: BMJ (1996)

Born and raised in Oldham, in the heart of rugby league territory, it was only natural that I should often climb the hill from home to the Watersheddings ground to watch the Roughyeds play “the greatest game of all.” Medical school in Liverpool, however, thrust me into a soccer obsessed city where the medical school rugby team offered only a game of the tedious and uninspiring plod for the …
Scheme to register all those who work with children is put on hold
Authors: C. Dyer
Journal: BMJ (2010)

A controversial “vetting and barring” scheme for people working with children and vulnerable adults, which would have covered most doctors practising in the United Kingdom, is to be halted and recast in a more “commonsense” way by the new Conservative and Liberal Democrat coalition government.

The scheme, set up by the previous Labour government in response to the murders of the schoolgirls Holly Wells and Jessica Chapman by the school caretaker Ian Huntley in 2002, would have been the largest child protection register in the world, with nine million adults required to register.

The scheme covers England, Wales, and …
Bronchodilator treatment in asthama: Authors' reply
Authors: R W Fuller, W M Castle, J R Hall, J B D Palmer
Journal: BMJ (1993)

salmeterol, although relieving symptoms, may mask or even increase the severity of the underlying disease.'The mortality data provided by Win Castle and colleagues do not alleviate current concerns that the frequent or regular use of f agonist drugs may be contributing to morbidity due to and mortality from asthma.
Triple Therapy
Authors: Mayer B. Davidson
Journal: Diabetes Care (2004)

In this issue of Diabetes Care , Strowig, Aviles-Santa, and Raskin (1) evaluated the glycemic response to “triple therapy” in a small number of patients. Their study of triple therapy involved adding metformin to type 2 diabetic patients receiving >30 units of insulin plus troglitazone or adding troglitazone to similar patients receiving >30 units of insulin plus metformin. The added oral antidiabetes medications were titrated upward over 1 month to maximal doses and the patients followed for another 3 months without further changes in their doses. Insulin doses were not allowed to be increased but could be decreased in response to hypoglycemia. Although these patients were well controlled at baseline, their control improved even further with this triple therapy. A1C levels in patients in whom troglitazone was added fell from 7.0 ± 0.8% (mean ± SD) at baseline to 6.1 ± 0.4%. Corresponding changes in A1C levels in the group receiving metformin as the third medication were 6.2 ± 0.8 to 5.8 ± 0.6%.

There is no agreement on what constitutes …
Fasting and postprandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjects
Authors: Seiko Otokozawa, Masumi Ai, Margaret R. Diffenderfer, Bela F. Asztalos, Akira Tanaka, Stefania Lamon-Fava, Ernst J. Schaefer
Journal: Metabolism (2009)
Pranayama: a divine power in sports
Authors: Vinuta Muktamath, Umesh Muktamath, Basavaraj Ganiger
Journal: British Journal of Sports Medicine (2010)

In day to life stress became a big problem in our society, especially in sports. Though a top class sportsman is having scientific coaching and proper nutrition, still he is lacking in showing top class performance because of more stress. Stresses always hamper the performance of an individual in sports competitions. Pranayama is the fourth limb and meditation is the seventh limb of ashtanga yoga. Its full significance has to be properly understood and appreciated. It consists of two components, pran and ayama. Pran is introduced by Sri Yogendraj has bio-energy and ayama means control or discipline. The real meaning of pranayama, therefore, is control of bio-energy. Prana is an essential living activity agent that works in the human body and makes the various function of the body possible. Since the stress is a main hurdle to the performance of sports men it shall be given higher priority to be treated. Numerous physiological effects have been reported due to meditation and pranayama. Lowering the heart beat rate and metabolism, as well as respiration and blood pressure. Also, the meditators significantly improve in the 50 m dash, standing broad jump and in an agility test. Since it does not require any costly instrument, simple in nature, it can adapt to any field to get rid of stress.
The antiviral effect of jiadifenoic acids C against coxsackievirus B3
Authors: Miao Ge, Huiqiang Wang, Guijie Zhang, Shishan Yu, Yuhuan Li
Journal: Acta Pharmaceutica Sinica B (2014)

Coxsackievirus B type 3 (CVB3) is one of the major causative pathogens associated with viral meningitis and myocarditis, which are widespread in the human population and especially prevalent in neonates and children. These infections can result in dilated cardiomyopathy (DCM) and other severe clinical complications. There are no vaccines or drugs approved for the prevention or therapy of CVB3-induced diseases. During screening for anti-CVB3 candidates in our previous studies, we found that jiadifenoic acids C exhibited strong antiviral activities against CVB3 as well as other strains of Coxsackie B viruses (CVBs). The present studies were carried out to evaluate the antiviral activities of jiadifenoic acids C. Results showed that jiadifenoic acids C could reduce CVB3 RNA and proteins synthesis in a dose-dependent manner. Jiadifenoic acids C also had a similar antiviral effect on the pleconaril-resistant variant of CVB3. We further examined the impact of jiadifenoic acids C on the synthesis of viral structural and non-structural proteins, finding that jiadifenoic acids C could reduce VP1 and 3D protein production. A time-course study with Vero cells showed that jiadifenoic acids C displayed significant antiviral activities at 0-6 h after CVB3 inoculation, indicating that jiadifenoic acids C functioned at an early step of CVB3 replication. However, jiadifenoic acids C had no prophylactic effect against CVB3. Taken together, we show that jiadifenoic acids C exhibit strong antiviral activities against all strains of CVB, including the pleconaril-resistant variant. Our study could provide a significant lead for anti-CVB3 drug development.
Contemporary Trends of Hospitalization for Atrial Fibrillation in the United States, 2000 Through 2010
Authors: Nileshkumar J. Patel, Abhishek Deshmukh, Sadip Pant, Vikas Singh, Nilay Patel, Shilpkumar Arora, Neeraj Shah, Ankit Chothani, Ghanshyambhai T. Savani, Kathan Mehta, Valay Parikh, Ankit Rathod, Apurva O. Badheka, James Lafferty, Marcin Kowalski, Jawahar L. Mehta, Raul D. Mitrani, Juan F. Viles-Gonzalez, Hakan Paydak
Journal: Circulation (2014)

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The associated morbidity and mortality make AF a major public health burden. Hospitalizations account for the majority of the economic cost burden associated with AF. The main objective of this study is to examine the trends of AF-related hospitalizations in the United States and to compare patient characteristics, outcomes, and comorbid diagnoses.With the use of the Nationwide Inpatient Sample from 2000 through 2010, we identified AF-related hospitalizations using International Classification of Diseases, 9th Revision, Clinical Modification code 427.31 as the principal discharge diagnosis. Overall AF hospitalizations increased by 23% from 2000 to 2010, particularly in patients ≥65 years of age. The most frequent coexisting conditions were hypertension (60.0%), diabetes mellitus (21.5%), and chronic pulmonary disease (20.0%). Overall in-hospital mortality was 1%. The mortality rate was highest in the group of patients ≥80 years of age (1.9%) and in the group of patients with concomitant heart failure (8.2%). In-hospital mortality rate decreased significantly from 1.2% in 2000 to 0.9% in 2010 (29.2% decrease; P<0.001). Although there was no significant change in mean length of stay, mean cost of AF hospitalization increased significantly from $6410 in 2001 to $8439 in 2010 (24.0% increase; P<0.001).Hospitalization rates for AF have increased exponentially among US adults from 2000 to 2010. The proportion of comorbid chronic diseases has also increased significantly. The last decade has witnessed an overall decline in hospital mortality; however, the hospitalization cost has significantly increased.
A 38-Year-Old Woman With Fetal Loss and Hysterectomy
Authors: Benjamin P. Sachs
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis
Authors: Joseph A. Gebbia, Juan Carlos Garcia Monco, Jay L. Degen, Thomas H. Bugge, Jorge L. Benach
Journal: Journal of Clinical Investigation (1999)

The role of the plasminogen activation system (PAS) was investigated during the course of infection of a relapsing fever Borrelia species in plasminogen-deficient (plg –/–) and control (plg+/+ and plg+/–) mice. Subcutaneous inoculation of 104 spirochetes resulted in a peak spirochetemia five days after infection with 20–23 × 106 organisms per milliliter of whole blood in all mice, indicating that the PAS had no effect on the development of this phase of the infection. Anemia, thrombocytopenia, hepatitis, carditis, and splenomegaly were noted in all mice during and immediately after peak spirochetemia. Fibrin deposition in organs was noted in plg–/– mice but not in controls during these stages. Significantly greater spirochetal DNA burdens were consistently observed in the hearts and brains of control mice 28–30 days after infection, as determined by PCR amplification of this organism's flagellin gene (flaB), followed by quantitative densitometry. Furthermore, the decreased spirochetal load in brains of plg –/– mice was associated with a significant decrease in the degree of inflammation of the leptomeninges in these mice. These findings indicate a role for the PAS in heart and brain invasion by relapsing fever Borrelia, resulting in organ injury.
A Sadly Troubled History: The Meanings of Suicide in the Modern Age
Authors: Antolin C. Trinidad
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment
Authors: Federica Cattaneo, Mike Recher, Stefania Masneri, Sachin N. Baxi, Claudia Fiorini, Francesca Antonelli, Christian A. Wysocki, Jose G. Calderon, Hermann Eibel, Angela R. Smith, Francisco A. Bonilla, Erdyni Tsitsikov, Silvia Giliani, Luigi D. Notarangelo, Sung-Yun Pai
Journal: Journal of Allergy and Clinical Immunology (2013)
An unusual treatment: Intractable hiccups
Authors: J. Macdonald
Journal: BMJ (1999)

treatment mainly directed at musculoskeletal and other painful conditions and are usually based in pain clinics or in general practice. TrainingProfessional acupuncturists train for up to 3-4 years full time and may acquire university degrees on completion of their training.Some complete further training in the principles and practice of Chinese herbalism.All accredited acupuncture training courses include conventional anatomy, physiology, pathology, and diagnosis.Research and audit skills are also taught.Medical acupuncturists generally have fewer training hours in acupuncture techniques-a course of several weekends in which they learn a small range of simple techniques is typical.Other conventional healthcare disciplines run courses for their own members, ranging from basic introductions to two year training in advanced acupuncture. RegulationProfessional acupuncturists have a single regulatory body, the British Acupuncture Council (BAcC), with about 1500 members.The council aims to achieve statutory regulation, although no final decisions have been made.All members have undergone a training independently accredited by the British Acupuncture Accreditation Board.Physiotherapists are regulated by the Acupuncture Association of Chartered Physiotherapists (AACP).Although many doctors practise some basic acupuncture without an official qualification, the British Medical Acupuncture Society offers a Certificate of Basic Competence and a Diploma of Medical Acupuncture for appropriately trained doctors.
Diverticular disease of the colon.
Authors: N. S. Painter
Journal: BMJ (1968)

Asymptomatic(2) Symptomatic-vague dyspeptic symptoms and variable bowel habit Caused by abnormal activity of colonic muscle ACUTE DIVERTICULITIS cated diverticulitis, even though it was known that resection could cure the disease and its complications.Fortunately, Smithwick3 showed that resection of the sigmoid could be performed with an acceptable mortality and that this cured the disease.Since then surgery has become safer owing to improved anaesthesia and supportive therapy, so that today elective resection of the diseased colon is the standard treatment of diverticular disease with complications.
Tumour progression in a patient with granulomatous mycosis fungoides
Authors: E. PAPADAVID, R.C. YU, C. BUNKER, D. SCOONES, A.C. CHU
Journal: British Journal of Dermatology (1996)

We report a patient with granulomatous mycosis fungoides whose disease transformed into a high grade blast lymphoma with angiocentric features within 12 months of the initial diagnosis. This repudiates previous claims that granulomatous inflammation is protective in cutaneous T-cell lymphoma.
Intravenous adenosine: Continuous infusion and low dose bolus administration for determination of coronary vasodilator reserve in patients with and without coronary artery disease
Authors: Morton J. Kern, Ubeydullah Deligonul, Satyanarayana Tatineni, Harvey Serota, Frank Aguirre, Thomas C. Hilton
Journal: Journal of the American College of Cardiology (1991)
THE RISE, PROGRESS AND PRESENT NEEDS OF PEDIATRICS.
Authors: J. P. CROZER GRIFFTH
Journal: JAMA (1898)

The honor which you have done me in electing me your chairman brings with it the duty of opening the session with an address. I have chosen as my subject one of great importance to us, one in which I have felt great interest and to which I have given considerable thought during a number of years, and I dwell on it now hoping to awaken in you, if need be, an equal interest in the matter, and that together we may aid in advancing the position of the branch of medical science which we represent today. The subject to which I refer treats of the rise of pediatrics as a specialty, its present position as compared with its past and its needs for future growth. I can give you but an incomplete sketch, lacking in very many of the most important details. One is often surprised that our medical
Statin therapy in lupus-mediated atherogenesis: two birds with one stone?
Authors: S. I. van Leuven, Y. V. Mendez-Fernandez, E. S. Stroes, P. P. Tak, A. S. Major
Journal: Annals of the Rheumatic Diseases (2010)

The atherosclerotic process is accelerated in patients with systemic lupus erythematosus (SLE). In addition to a robust lipid-lowering effect, various immunomodulatory functions have been ascribed to statins. By virtue of the latter they may be able to reduce atherosclerotic vascular disease in SLE by inhibiting immune activation within the arterial wall and by attenuating lupus activity. The effects of statins on SLE as well as on lupus-mediated atherogenesis in vivo are discussed in this viewpoint.
Epidemiology of rheumatic diseases in rural and urban populations in Indonesia: a World Health Organisation International League Against Rheumatism COPCORD study, stage I, phase 2.
Authors: J Darmawan, H A Valkenburg, K D Muirden, R D Wigley
Journal: Annals of the Rheumatic Diseases (1992)

To determine the incidence of musculoskeletal pain, disabilities, and help seeking behaviour, a questionnaire was administered to a rural population of 2184 men and 2499 women and an urban population of 481 men and 590 women aged over 15 years by house to house interviews with completion rates of 95.2% (rural) and 97.1% (urban). The incidences of pain in the joints, back, or neck were 23.6% (rural) and 31.3% (urban). The incidence of disability due to an inability to walk, lift, carry, and dress was 2.8% (rural) and 0.9% (urban). The percentage of the population with pain who had to stop work owing to disability was 75% (rural) and 78% (urban). Official health care facilities were used by 62% (rural) and 71% (urban) of the population. Traditional health care was used by 87% (rural) and 89% (urban). The high percentage of subjects unable to work was due to a predominance of manual labour occupations (rural, 90%, urban, 80%). The age and sex specific incidence of rheumatic diseases in these populations were similar to other developing and developed countries. The primary rheumatology service was inadequate due to the low priority given by the health service to non-communicable diseases and inadequate rheumatology teaching of the primary health care doctors during undergraduate training. Musculoskeletal pain is a major public health problem in Indonesia and is still not fully appreciated.