Aspirin-Induced Hepatic Injury
Authors: HYMAN J. ZIMMERMAN
Journal: Annals of Internal Medicine (1974)

Editorials1 January 1974Aspirin-Induced Hepatic InjuryHYMAN J. ZIMMERMAN, M.D.HYMAN J. ZIMMERMAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-1-103 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOld drugs are like old friends. One knows their faults and potential for creating problems. The incidence and gravity of adverse effects of pharmacologic old friends can be weighed against their therapeutic benefits. One is more wary of new acquaintances and regards new drugs with a jaundiced eye—often literally. When newly introduced drugs lead to hepatic injury or other disturbing side effects, the phenomenon is usually recognized during the first several years of use. Thus, the potential for chlorpromazine to produce jaundice was recognized shortly after the drug found wide clinical use (1). Within several years after halothane came into...References1. ZIMMERMAN H: Drug-Induced Hepatic Injury, in Hypersensitivity to Drugs, edited by SAMTER M, New York, Pergamon Press, 1972, p. 299-365 Google Scholar2. MADDREYBOITNOTT WJ: Isoniazid hepatitis. Ann Intern Med 79:1-12, 1973 LinkGoogle Scholar3. STEADTEXTER WE: Isoniazid hepatitis: backlash of progress. Ann Intern Med 79:125-127, 1973 LinkGoogle Scholar4. GARIBALDIDRUSINFEREBEE RRS: Isoniazid-associated hepatitis: report of an outbreak. Am Rev Resp Dis 106:357-365, 1972 CrossrefMedlineGoogle Scholar5. ZIMMERMAN H: Papaverine revisted as hepatotoxin. N Engl J Med, 281:1364, 1969 CrossrefMedlineGoogle Scholar6. SHELLEY J: Phenacetin, through the looking glass. Clin Pharmacol Ther 8:427-471, 1967 CrossrefMedlineGoogle Scholar7. Editorial: Liver injury by salicylates. Br Med J, 2:732, 1973 CrossrefGoogle Scholar8. SEAMANISHAKPLOTZ WKP: Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus. Ann Intern Med 80:000-000, 1974 LinkGoogle Scholar9. 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Am J Dis Child 69:37-43, 1945 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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