tbuckley/cabot-search huggingface dataset:
Abstract 658: Fruit and vegetable intake and cancer incidence in Korean men
Authors: Jung Eun Lee, Dong-Hyun Kim, Yoon-Ok Ahn
Journal: Cancer Research (2012)

Abstract Few prospective cohort studies have examined the association between fruit and vegetable intake and cancer incidence in Asian population, who consume a diet rich in fruit and vegetable and experience dramatic change in their diet. We investigated whether total fruit intake, total vegetable intake, and total fruit and vegetable intake were associated with risk of incident cancers among 13,563 Korean men during 15 years of follow-up. We used the Cox proportional hazards model to calculate relative risks (RRs) and 95% confidence intervals (CIs) for incident cancers according to fruit and vegetable intake assessed by a validated food frequency-questionnaire. All statistical tests were two-sided. We identified a total of 831 incident cancers. We observed that low intake of total vegetable intake or total fruit and vegetable intake was associated with increased risk of overall cancer incidence. The risk reduction was attributable to increasing intake above a threshold of approximately 100 to 150 g/d. For example, compared with &amp;lt;100 g/d of total fruit and vegetable intake, RRs (95% CIs) for overall cancer risk were 0.74 (0.53-1.02) for 100-&amp;lt;300 g/d, 0.73 (0.53-1.01) for 300-&amp;lt;500 g/d, 0.76 (0.53-1.11) for 500-&amp;lt;600 g/d, and 0.71 (0.51-0.99) for 600 or more g/d. However, when we chose &amp;lt;200 g/d as the referent category, we did not observe the statistically significant associations. In conclusion, our findings suggest that low levels of fruit and vegetable intake could pose an increase in risk of cancer, but the risk could be minimized with modestly increasing intake. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 658. doi:1538-7445.AM2012-658
Effect of a gluten free diet on osteopenia in adults with newly diagnosed coeliac disease.
Authors: X A McFarlane, A K Bhalla, D A Robertson
Journal: Gut (1996)

BACKGROUND/AIMS: Calcium and vitamin D malabsorption in coeliac disease predispose to skeletal demineralisation. This study aimed to determine bone mineral density in patients studied in the first year after diagnosis of coeliac disease, and to detect changes in bone mineral density over the subsequent year. METHODS: Lumbar spine and femoral neck bone mineral density was measured in 21 adults with coeliac disease, diagnosed and started on a gluten free diet during the preceding year, with dual energy x ray absorptiometry and repeated after 12 months. RESULTS: Bone mineral density was significantly lower in patients than in paired controls (matched for age and sex), at lumbar spine (0.819 g/cm2 compared with 1.021 g/cm2, p &lt; 0.001 Wilcoxon signed rank test) and femoral neck (0.663 g/cm2 compared with 0.794 g/cm2, p &lt; 0.001). Repeat measurement after 12 months demonstrated that patients had a significant gain in bone mineral density at lumbar spine (16.6%/year), and femoral neck (15.5%/year, p &lt; 0.002, Wilcoxon signed rank test at both sites), whereas no significant change in bone mineral density was detected in controls. CONCLUSIONS: Treatment of coeliac disease with a gluten free diet is associated with a significant increase in bone mineral density, although patients still had lower bone mineral density than controls.
Temporary heterotopic auxiliary liver transplantation for fulminant hepatitis B
Authors: Bart van Hoek, Jan Ringers, Alouis C.M. Kroes, Johan H.J.M. van Krieken, W.Dick van Schelven, Ad A.M. Masclee, Laura G.van Krikken-Hogenberk, Harm R. Haak, Cornelis B.H.W. Lamers, Onno T. Terpstra
Journal: Journal of Hepatology (1995)
CENTRAL VENOUS VERSUS ARTERIAL BLOOD GAS VALUES
Authors: TSUNG O. CHENG
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 October 1969CENTRAL VENOUS VERSUS ARTERIAL BLOOD GAS VALUESTSUNG O. CHENG, M.D., F.A.C.P.TSUNG O. CHENG, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-4-870 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The recent article by Phillips and Peretz on the use of central venous blood for monitoring pH and Pco2 (Ann. Intern. Med. 70: 745, 1969) is a valuable contribution to a more precise management of the critically ill. However, a few words of caution should be said here with regard to the degree of reliability with which the central venous blood values may be used to predict the precise levels in arterial blood.First, a distinction should be made between central venous blood and mixed venous blood. Whereas mixed venous blood Pco2(which incidentally, may be obtained...References1. PETTYBIGELOWLEVINE TLDBBE: The simplicity and safety of arterial puncture. JAMA, 195: 693, 1966. CrossrefMedlineGoogle Scholar2. SNIDERMALDONADO GLD: Arterial blood gases in acutely ill patients. JAMA 204: 991, 1968. CrossrefMedlineGoogle Scholar3. FLENLEY DC: The rationale of oxygen therapy. Lancet 1: 270, 1967. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cardiovascular Laboratory V.A. Hospital State University of New York Downstate Medical Center Brooklyn, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1969Volume 71, Issue 4Page: 870-871KeywordsArterial blood gasBloodPartial pressure of carbon dioxide Issue Published: 1 October 1969 PDF DownloadLoading ...
Erratum to “Cord Blood-Hematopoietic Stem Cell Expansion in 3D Fibrin Scaffolds with Stromal Support” [Biomaterials 33 6987–6997]
Authors: Mónica S. Ventura Ferreira, Willi Jahnen-Dechent, Norina Labude, Manfred Bovi, Thomas Hieronymus, Martin Zenke, Rebekka K. Schneider, Sabine Neuss
Journal: Biomaterials (2012)
National Organ Matching and Distribution Service
Authors: S. D. Nelson, G. H. Tovey
Journal: BMJ (1974)

In the first eleven months of the National Organ Matching and Distribution Service 455 kidney transplants were notified. A high proportion of first transplants failed within seven days of operation, probably reflecting low quality of some of the donor kidneys supplied. To improve the results of renal transplantation and to serve the increasing number of potential recipients registered with the service, as well as to obtain the optimum blood and tissue group compatibility of donor and recipient, many more kidneys are needed.
The distribution of sodium-potassium-activated adenosine triphosphatase in medulla and cortex of the kidney
Authors: Ernesto D. Hendler, Jorge Torretti, Franklin H. Epstein
Journal: Journal of Clinical Investigation (1971)

The activity of sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) is considerably higher in homogenates of outer medulla than in the cortex or papilla of the kidney. The enzyme has similar kinetic characteristics in both cortex and medulla, and binds ouabain in the same proportion. The discrepancy in enzymatic activity is not paralleled by similar change in the activity of adenyl cyclase, 5'nucleotidase, glucose-6-phosphatase, or succinic dehydrogenase. Na-K-ATPase is also higher in distal convoluted tubules (ventral slices) than in the proximal tubules (dorsal slices) of the kidney of Amphiuma. The high concentration of Na-K-ATPase in the red medulla of the kidney is probably related to the presence here of the thick ascending limb of the loop of Henle, and this has important implications with regard to the mechanism of sodium reabsorption by different portions of the nephron.
Bone growth oscillation: Longitudinal metabolic process of bone growth in congenital adrenal hyperplasia and nonendocrine short stature
Authors: O. Arisaka, H. Kanno, M. Negishi, M. Kojima, K. Nishikura, M. Numata, S. Kanazawa, A. Nitta, T. Kuribayashi, K. Kano
Journal: Metabolism (2002)
Undergraduate Medical Education
Authors: Basil R. Meyerowitz
Journal: JAMA (1973)

To the Editor.—  I write in support of Dr. Rosinski's recommended revision of undergraduate  education (222:473, 1972).  In 1968,I made a similar proposal. 1 In essence, I indicated that the undergraduate  curriculum was failing because it was trying to do too many things at one and the same time. It aimed to produce excellent physicians at two levels—family practitioners (Dr. Rosinski's medical practitioners) and well-trained graduates for the specialty-residency programs (medical clinicians). In addition, I indicated that  schools were aiming to produce men and women who are highly motivated to careers in research (medical scientists).  I agree with him entirely that there needs to be a redefinition of the goals of our  schools. My solution was to increase the enrolling class and give all students a two-year study of the basic sciences along the lines he suggested. At the end of the second year, the group
Cloretazine (VNP40101M), a Novel Sulfonylhydrazine Alkylating Agent, in Patients Age 60 Years or Older With Previously Untreated Acute Myeloid Leukemia
Authors: Francis Giles, David Rizzieri, Judith Karp, Norbert Vey, Farhad Ravandi, Stefan Faderl, Khuda Dad Khan, Gregor Verhoef, Pierre Wijermans, Anjali Advani, Gail Roboz, Hagop Kantarjian, Syed Fazl Ali Bilgrami, Augustin Ferrant, Simon M.G.J. Daenen, Verena Karsten, Ann Cahill, Maher Albitar, Ghulam Mufti, Susan O'Brien
Journal: Journal of Clinical Oncology (2006)

Cloretazine (VNP40101M) is a sulfonylhydrazine alkylating agent with significant antileukemia activity. A multicenter phase II study of cloretazine was conducted in patients 60 years of age or older with previously untreated acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS).Cloretazine 600 mg/m2 was administered as a single intravenous infusion. Patients were stratified by age, performance score, cytogenetic risk category, type of AML, and comorbidity.One hundred four patients, median age 72 years (range, 60 to 84 years), were treated on study. Performance status was 2 in 31 patients (30%) and no patient had a favorable karyotype. Forty-seven patients (45%) had cardiac disease, 25 patients (24%) had hepatic disease, and 19 patients (18%) had pulmonary disease, defined as per the Hematopoietic Cell Transplantation-Specific Comorbidity Index, at study entry. The overall response rate was 32%, with 29 patients (28%) achieving complete response (CR) and four patients (4%) achieving CR with incomplete platelet recovery. Response rates in 44 de novo AML patients, 45 secondary AML patients, and 15 high-risk MDS patients were 50%, 11%, and 40%, respectively. Response by cytogenetic risk category was 39% in 56 patients with intermediate cytogenetic risk and 24% in 46 patients with unfavorable cytogenetic risk. Nineteen (18%) patients died within 30 days of receiving cloretazine therapy. Median overall survival was 94 days, with a 1-year survival of 14%; the median duration of survival was 147 days, with a 1-year survival of 28% for those who achieved CR.Cloretazine has significant activity and modest extramedullary toxicity in elderly patients with AML or high-risk MDS. Response rates remain consistent despite increasing age and comorbidity.
The International Scientific Language.
Authors: Casey A. Wood
Journal: JAMA (1896)

Chicago, Dec. 23, 1895. <h3>To the Editor:</h3> —I was very much pleased with your article in the last number of theJournalon "The International Scientific Language," and I think that in the main I agree with you. But I feel sure that you did not lay sufficient stress upon the unfortunate fact that the ability to speak French is quite a different thing from the translating knowledge. The former is rarely acquired after a certain age and almost never outside of a French school or a French-speaking locality. For instance, the only French that I heard spoken by Americans at the Pan-American Medical Congress—with one or two notable exceptions—was of that variety which Chaucer designated as of " Stratford-atte-Bow," and it was excessively painful to listen to. When the time comes that a man will commence to prepare himself for the study and practice of medicine at 12 years of
A Case of Abscess of Abdominal Wall Following Typhoid Fever: Incision: Recovery
Authors: G. Westby
Journal: BMJ (1897)

neuritis.It is interesting to note that optic neuritis is not mentioned as occurring in enteric fever by either Fagge, Osler, or Strtimpell, while Sir William Broadbent, in Quain's Dictionary,mentions it onlyas an almost pathognomonic sign of meningitis.On the other hand, Gowers speaks of it as being not uncommon in both enteric and scarlet fevers; and Taylor records a similar case that has come under his notice.
Carcinoma in situ of the testis: aneuploid cells in semen
Authors: A. Giwercman, O. P. F Clausen, N. E Skakkebaek
Journal: BMJ (1988)

The content of cellular DNA in ejaculates from eight patients with carcinoma in situ of the testis and 26 controls without evidence of testicular neoplasia was studied by flow cytometry. An aneuploid cell population with a ploidy value similar to that found for carcinoma in situ cells was detected in seminal fluid from four of the eight men with carcinoma in situ but in none of the controls. One year after orchidectomy or local irradiation in these four men no aneuploid cells were found in the semen. These findings show that a detectable proportion of malignant germ cells may be released into the seminal fluid of patients with carcinoma in situ of the testis. Analysis of seminal fluid may therefore aid in screening for early neoplasia of the testis.
Tc-99m Galactosyl-Neoglycoalbumin Hepatic Scintigraphy in Fulminant Hepatic Failure
Authors: MERCÈ MORAGAS, JAVIER PAVÍA, ANGELS GINÉS, DOMÈNEC ROS, MONTSERRAT SOLÁ, MARINA HUGUET, FRANCESCA PONS, JORDI SETOAIN
Journal: Clinical Nuclear Medicine (1995)

Tc-99m galactosyl-neoglycoalbumin (NGA) is a new liver imaging agent that specifically binds to a hepatocyte specific membrane receptor, the hepatic binding protein. Scintigraphy with Tc-99m NGA is a noninvasive method that provides functional images of the liver. This report deals with one case of fulminant hepatic failure in which hepatic Scintigraphy with Tc-99m NGA predicted hepatic recovery before clinical and biochemical parameters, being a prognostic index in this patient.
High Rate of Spontaneous Normalization of Celiac Serology in a Cohort of 446 Children With Type 1 Diabetes: A Prospective Study
Authors: Stefania Castellaneta, Elvira Piccinno, Marica Oliva, Fernanda Cristofori, Marcella Vendemiale, Federica Ortolani, Francesco Papadia, Carlo Catassi, Luciano Cavallo, Ruggiero Francavilla
Journal: Diabetes Care (2015)

OBJECTIVE In children with type 1 diabetes mellitus (T1DM), elevated levels of antitissue transglutaminase (anti-tTG) antibody may spontaneously normalize, despite continued consumption of gluten. We aimed to investigate the prevalence of spontaneous normalization of anti-tTG levels and the existence of factors predictive for this outcome. RESEARCH DESIGN AND METHODS All children referred from 2002 to 2012 were screened for celiac disease (CD) at diabetes onset and at specific intervals. In the presence of a high anti-tTG titer or clinical symptoms, children were offered endoscopy, and asymptomatic patients with a low anti-tTG titer were invited to a second serological test after 6 months of eating a gluten-containing diet. RESULTS The study included 446 children. Of these, 65 (14.5%) became positive for celiac serology: 38 (58%) had a persistently elevated anti-tTG titer and 27 (41%) fluctuating anti-tTG titer; 18 (28%) became negative. The prevalence of positive CD autoimmunity and overt CD was 14.3% (95% CI 11–17) and 8.5% (95% CI 5–10), 15- and 8-times higher than the general pediatric population, respectively. Asymptomatic children older than 9.1 years at T1DM onset had the lowest risk to develop CD. CONCLUSIONS Serum anti-tTG levels decreased spontaneously in 40% of children with T1DM and became negative in 20%, despite gluten consumption. This finding supports the hypothesis of a state of temporary positivity of celiac serology in children with diabetes. In absence of clinical symptoms or signs of CD, histological confirmation of the disease and the gluten-free diet should be postponed to avoid unnecessary procedures and reduce an additional psychological burden.
Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
Authors: Yoko Kidani, Heidi Elsaesser, M Benjamin Hock, Laurent Vergnes, Kevin J Williams, Joseph P Argus, Beth N Marbois, Evangelia Komisopoulou, Elizabeth B Wilson, Timothy F Osborne, Thomas G Graeber, Karen Reue, David G Brooks, Steven J Bensinger
Journal: Nature Immunology (2013)
Less Is More
Authors: Dimitrios Linos
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
A CASE OF CEREBRAL ABSCESS OF OTIC ORIGIN
Authors: H. Bodkin
Journal: BMJ (1917)

APRIL 21, 17 and vein would be sure to iinvite the risk of gangrene.The sides of the wounid were then drawni together at each end and the c6ntre packed with gauze soaked in euisol.The wouind in the knee was excised ancl openedl up freely, wheni it was seen that the joinit had not been enitered, but that the patellar ligameint with the tuberosity of the tibia had been torn away.Loose boine was scrared out an(d the wound packed with gauze anld eeusol.The wouLnd in the right groiln was excised, the traclk followetl dowil about eight inches *to the a(lductor muscles.A counter opening was made, the track well scrape(l out, and a rubber tube placedl along it.The scal)p wounid, tlhrough an oversight, was nlot excised, and the patient was returnied to be(d with the right leg enveloped in cotton-wool aiid placed il all elevated position.Qn recovering from the anaesthetic he was placed in the Fowler positioIn.Thie next day the patient was very ill inldeed.Pulse 130, respirations 30, temperature 990 F. Hie was given morplhine freely.He had onie and a half grains of morplline lhypodermically in the twenity-four hours anid saliines lPer rectum; which he retained, also a turpenitine eniema to relieve some distensioni.December 19th.He was better and had had a good night.Dressinlgs were soalked through, so he was dressed.There was no dtscharge from tli-e lower abdominal tube, but a free dis- charge of bile from the upper one, free oozing from the left
Heat Stress Attenuates Ventilator-induced Lung Dysfunction in an <i>Ex vivo</i> Rat Lung Model
Authors: SERGIO P. RIBEIRO, KUNUK RHEE, LORRAINE TREMBLAY, RUUD VELDHUIZEN, JAMES F. LEWIS, ARTHUR S. SLUTSKY
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Our laboratory has previously shown decreased mortality rates and the attenuation of lung injury in rats exposed to heat stress (H) 18 h prior to induction of sepsis. In the present study, we examined the hypothesis that heat stress would protect lungs against ventilator-induced lung injury. Male Sprague–Dawley rats were anesthetized and randomly allocated to receive either sham treatment or exposure to heat (rectal temperature 41 ° C, for 15 min). The lungs were harvested 18 h later, a pressure–volume (P– V) curve was constructed, and the lungs were either lavaged for cytokine and surfactant analyses (preventilation data) or were mechanically ventilated with Vt 40 ml/kg in a warmed, humidified chamber. After 2 h of mechanical ventilation, another P–V curve was constructed and the lungs were lavaged for cytokine and surfactant analyses (postventilation data). Mechanical ventilation in control lungs produced a 47% decrease in chord compliance, an increase in lung lavage levels of tumor necrosis factor (TNF)- α (722 ± 306 pg/ml), interleukin (IL)-1 β (902 ± 322 pg/ml), and macrophage inflammatory protein-2 (MIP-2) (363 ± 104 pg/ml) as compared with low levels of cytokines detected in preventilation data, and no change in percentage of surfactant large aggregates (LA). In contrast, in mechanically ventilated lungs from animals that were exposed to heat stress we observed a smaller decrease in chord compliance (17%), a significant attenuation in cytokine levels (TNF- α 233 ± 119 pg/ml; IL-1 β 124 ± 53 pg/ml; MIP-2 73 ± 52 pg/ml; p < 0.05) and a significant increase in percentage LA compared with control animals. We conclude that exposing animals to heat stress confers protection against the effects of an injurious form of mechanical ventilation, by a mechanism that may involve attenuation of cytokines and preservation of some surfactant properties.
No Association between the Methyleletetrahydrofolate Reductase A1298C Variants and Atrial Fibrillation with Ischemic Stroke in Turkish Population
Authors: Atilla İçli, Nilgün Erten, Akif Arslan, Habil Yücel, Salaheddin Akçay, Erdoğan Yaşar, Bayram Ali Uysal, Hasan Aydın Baş, Fatih Aksoy, Recep Sütçü
Journal: Journal of the American College of Cardiology (2013)
501 18-BETA-GLYCYRRHETIC ACID, METABOLITE OF GLYCYRRHIZIN, INDUCES APOPTOSIS AND SUPPRESS THE EXPRESSION OF COLLAGEN TYPE I GENE IN HEPATIC STELLATE CELLS
Authors: A. Yanagida, E. Hatano, N. Uyama, M. Narita, H. Asechi, H. Nagata, K. Ikeda, N. Kawada, I. Ikai, S. Uemoto
Journal: Journal of Hepatology (2008)
Is sequence-in/sequence-out a cerebellar mode of operation in cognition too?
Authors: Marco Molinari, Laura Petrosini
Journal: Behavioral and Brain Sciences (1997)

This commentary reinterprets our recent data on the cerebellar contribution to different cognitive functions in light of Braitenberg and coworkers's hypothesis about the sequence-in/sequence-out cerebellar mode of operation in the motor domain. Cerebellar involvement in spatial data processing, procedural learning, verbal fluency, application of grammatical rules, and writing is dependent on sequence processing.
990 PEGINTERFERON ALPHA-2A PLUS RIBAVIRIN VERSUS PEGINTERFERON ALPHA-2B PLUS RIBAVIRIN IN NAIVE PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION: RESULTS OF A PROSPECTIVE RANDOMISED TRIAL
Authors: A. Ascione, M. De Luca, M.T. Tartaglione, F. Lampasi, A. Galeota Lanza, F.P. Picciotto, G.G. Di Costanzo, G. Leandro
Journal: Journal of Hepatology (2008)