Colony-Stimulating Factors and Neutrophil Migration
Authors: Guy C. Toner
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 May 1989Colony-Stimulating Factors and Neutrophil MigrationGuy C. Toner, MBBS, Ann A. Jakubowski, MD, John P.L. Crown, MD, Barry Meisenberg, MD, Carol Sheridan, RN, Janice L. Gabrilove, MDGuy C. Toner, MBBSSearch for more papers by this author, Ann A. Jakubowski, MDSearch for more papers by this author, John P.L. Crown, MDSearch for more papers by this author, Barry Meisenberg, MDSearch for more papers by this author, Carol Sheridan, RNSearch for more papers by this author, Janice L. Gabrilove, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-10-846 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Clinical trials of hemopoietic growth factors have concentrated on the ability of these factors to increase circulating blood counts. Less emphasis has been given to the effects of these factors on the functional capabilities of the mature cells. There is substantial in-vitro and increasing in-vivo evidence that these growth factors may play an important role in immune function control by modulating effector cell function. The recently published UCLA Conference (1) provided a timely and thorough review of the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on host defense. An additional recent report, relevant to this topic, has...References1. Weisbart R. Colony-stimulating factors and host defense. Ann Intern Med. 1989;110:297-303. LinkGoogle Scholar2. PetersStuartAffrontiKimColeman WAMCR. Neutrophil migration is defective during recombinant human granulocyte-macrophage colony-stimulating factor infusion after autologous bone marrow transplantation in humans. Blood. 1988;72:1310-5. CrossrefMedlineGoogle Scholar3. SennHollandBanerjee HJT. Kinetic and comparative studies on localized leukocyte migration in normal man. J Lab Clin Med. 1969;74:742-56. MedlineGoogle Scholar4. WangCollelaAllavenaMantovani JSPA. Chemotactic activity of human recombinant granulocyte-macrophage colony-stimulating factor. Immunology. 1987;60:439-44. MedlineGoogle Scholar5. GassonWeisbartKaufman JRS. Purified human granulocyte-macrophage colony stimulating factor: direct action on neutrophils. Science. 1984;226:1339-42. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memorial Sloan-Kettering Cancer Center New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Influence of Colony-Stimulating Factors on Neutrophil Production, Distribution, and FunctionGranulocyte Colony Stimulating Factor (G-CSF): Biology and Clinical StatusG- and GM-CSF in oncology and oncological haematologyStudies of oral neutrophil levels in patients receiving G-CSF after autologous marrow transplantationColony-Stimulating Factors: A New Step in Clinical Practice. Part IEmerging clinical uses for GM-CSFLeukocyte Adhesion Molecule-1 (LAM-1): Structure, Function, Genetics, and Evolution 15 May 1989Volume 110, Issue 10Page: 846-847KeywordsBlood countsCellsClinical trialsColony stimulating factorGranulocyte macrophage colony stimulating factorGrowth factorsNeutrophils Issue Published: 15 May 1989 PDF DownloadLoading ...