tbuckley/cabot-search huggingface dataset:
816 Prostaglandin I2-analogue, beraprost sodium, prevents concanavalin A-induced liver injury through improvement of hepatic blood circulation and suppression of cytokine production in mice
Authors: S OHTA, M FUKUSHIMA, M KUNIYOSI, S MORIZONO, M ENJOJI, M NAKAMUTA
Journal: Hepatology (2003)

Plant-growth promoting bacteria can ameliorate the negative effects of salt stress on canola. To better understand the role of bacteria in canola under salt stress, salt-sensitive (Sarigol) and salt-tolerant (Hyola308) cultivars were inoculated with Pseudomonas fluorescens and protein profiles of roots were compared. Bacterial inoculation increased the dry weight and length of canola roots under salt stress. Using a gel-free proteomic technique, 55 commonly changed proteins were identified in Sarigol and Hyola308 roots inoculated with bacteria under salt stress. In both canola cultivars, proteins related to amino acid metabolism and tricarboxylic acid cycle were affected. Hierarchical cluster analysis divided the identified proteins into three clusters. Proteins related to Clusters II and III, which were secretion-associated RAS super family 1, dynamin-like protein, and histone, were increased in roots of both Sarigol and Hyola308 inoculated with bacteria under salt stress. Based on pathway mapping, proteins related to amino acid metabolism and the tricarboxylic acid cycle significantly changed in canola cultivars inoculated with or without bacteria under salt stress. These results suggest that bacterial inoculation of canola roots increases tolerance to salt stress by proteins related to energy metabolism and cell division.Plant-growth promoting bacteria as an emerging aid can ameliorate the negative effect of salt stress on canola. To understand the role of bacteria in canola under salt stress, salt sensitive Sarigol and tolerant Hyola308 cultivars were used. Dry weight and length of canola root were improved by inoculation of bacteria under salt stress. Using gel-free proteomic technique, 55 commonly changed proteins identified in Sarigol and Hyola308 inoculated with bacteria under salt stress. In both canola cultivars, the number of proteins related to amino acid metabolism and tricarboxylic acid cycle was more than other categories with higher change in protein abundance. Hierarchical cluster analysis divided into 3 clusters. Cluster II including secretion-associated RAS super family 1 and dynamin-like protein and Cluster III including histones H2A were increased by bacterial inoculation in both cultivars. Furthermore, pathway mapping highlighted the importance of S-denosylmethionine synthetase and malate dehydrogenase that decreased in canola inoculated with bacteria under salt stress. These results suggest that bacterial inoculation helps the canola to endure salt stress by modulating the proteins related to energy metabolism and cell division.
The Skeleton at Work
Authors: Charles Baudelaire
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Profiling the t cell repertoire in rheumatoid arthritis
Authors: L Su
Journal: Annals of the Rheumatic Diseases (2010)

Purpose Rheumatoid arthritis (RA) is one of the most common debilitating systemic infl ammatory conditions.To date, little is known about the autoantigens involved in RA and how T cells recognising self-proteins may become pathogenic in disease.The aim of this study is to determine whether autoreactive T cells in RA patients are different from those that can be found in healthy individuals.Method Autoantigen-specifi c T cells are identifi ed directly ex vivo using peptide-MHC tetramers.HLA-DR4 monomers with a tethered thrombin cleavable CLIP peptide were purifi ed from the culture supernatant of a stable HLA-DR4 transfectant cell line by antibody affi nity chromatography.The purifi ed monomers were then biotinylated, thrombin cleaved, loaded with peptides, and oligomerised onto a streptavidin backbone labeled with a fl uorophore.To identify individuals carrying the HLA-DRB1*0401 (DR4) allele, HLA typing was performed on healthy blood donors and RA patients using sequence-specifi c primer PCR.Individuals with DR4 allele(s) were selected for T cell repertoire analysis.To identify antigen-specifi c T cells, blood from DR4 positive individuals were enriched for CD4 cells by rosettasep/fi coll centrifugation.Tetramer staining was performed at room temperature for one hour using 10nM of tetramers loaded with peptides from hemagglutinin (HA) and the human glycoprotein 39 (Hcgp39).Memory phenotyping was performed
HYSTERECTOMY FOR FIBROID DISEASE IN THREE SISTERS: RECOVERY
Authors: A. Doran
Journal: BMJ (1905)

ACUTE inflammation of the lungs bearing a definite rnlation to the application of pbysical violence is, I think, of sufficient rarity to warrant publication.The following are the notes of such a case recently under my care.History.-Arthur M., an A.B. in H.M. navy, age 20, while on duty in a steamboat at 7 p.m, May 28tb, tripped and fell, striking his left arm and left side of chest violently against the gunwale.When he returred on board the d6p6t ship he mtade no complaint, and " turned in " without assistance.Admission to Sick Bay.-At 7 a.m. the following day, feeling very faint and sitiff, he lay down in the gallJ-v until 7.30 a.m., when he was brought to the sick bay.He then complained of hpadache, inability to move his left arm, vague pains over the left side of the chest, and a desire to pass water.His skin was hot and dry, his cheeks flushed, and his bladder distended.Temperature was 1040 F., pulse 120, respirations 28.He was put to bed, 30 oz. of clear nonalbuminous urine were drawn off by catheter, an enema was administered, and a diaphoretic prescribed thrice daily.No pbysical signs were observed in the heart or lungs.MAY.-I '-
Medallion-like dermal dendrocyte hamartoma: A new clinically and histopathologically distinct lesion
Authors: Rodolfo Rodrı́guez-Jurado, Carolina Palacios, Carola Durán-McKinster, Patricia Mercadillo, Luz Orozco-Covarrubias, Maria del Mar Saez-de-Ocariz, Ramón Ruiz-Maldonado
Journal: Journal of the American Academy of Dermatology (2004)
Sentinel Node Biopsy After Neoadjuvant Chemotherapy
Authors: Monica Morrow, Chau T. Dang
Journal: JAMA (2013)

Axillary lymph node dissection (ALND) reliably identifies lymph node metastases and results in a high rate of local cancer control, even in patients who initially present with node-postive disease. In patients initially presenting with node-negative breast cancer, ALND has been replaced by sentinel lymph node (SLN) biopsy. Sentinel lymph node biopsy involves injecting dye or tracer substances into the breast to selectively identify and remove the lymph nodes most likely to contain metastases. This is a much less morbid procedure than ALND.
Diagnostic Approach and Management of Lynch Syndrome (Hereditary Nonpolyposis Colorectal Carcinoma): A Guide for Clinicians
Authors: Y. M.C. Hendriks, A. E. de Jong, H. Morreau, C. M.J. Tops, H. F. Vasen, J. Th. Wijnen, M. H. Breuning, A. H.J.T. Brocker-Vriends
Journal: CA A Cancer Journal for Clinicians (2006)

ABSTRACT diagnostic workup of familial colorectal cancer is an elaborate and time consuming process in which the family and several medical specialists closely collaborate. However, establishing a diagnosis can be very rewarding. If a mutation is detected in the family, a satisfactory explanation can be provided for an accumulation of tumors at young age, and often of untimely death. Appropriate presymptomatic testing can be offered to reduce mortality among at-risk family members, and relatives not at risk can avoid uncertainty and needlessly intensive surveillance. We show the differential diagnostic considerations when an individual with a family history of colorectal carcinoma is encountered, with emphasis on Lynch syndrome (Hereditary Nonpolyposis Colorectal Carcinoma [HNPCC]). Practical recommendations for laboratory workup of suspected Lynch syndrome, including analysis of tumor tissue by microsatellite instability analysis and immunohistochemistry, and germline DNA analysis are given. Furthermore, the clinical management after a molecular diagnosis has been made is described. The diagnostic scheme presented here allows efficient and effective analysis of colorectal carcinoma cases with (suspected) Lynch syndrome, making optimal use of currently available technology.
SMALLPOX IN OHIO.
Authors: C. O. PROBST
Journal: JAMA (1899)

Ohio has been having a most interesting epidemic of smallpox during the past year, and I had hoped to be able to present a proper report of it to this meeting. During the past six or eight months, however, I have been kept so busy combatting the disease that I have had no opportunity to complete the report. A few weeks ago I wrote the Chairman that I would be unable to present the paper I had promised, but he informed me that the program had already been printed and that he would expect me to say something on the subject. I have, therefore, very hurriedly prepared a few remarks on some of the more interesting features of our epidemic. Smallpox made its appearance in Ohio April 6, 1898, and up to June 6, 1899, fourteen months, there have been reported 1882 cases and 30 deaths. Out of 88 counties
Murderer loses attempt to keep his medical records secret
Authors: Clare Dyer
Journal: BMJ (2006)

A double murderer lost his High Court bid to keep details of his medical records secret in the United Kingdom last week.

Michael Stone, who murdered Lin Russell and her 6 year old daughter Megan on a country lane in Kent 10 years ago, argued that his personal medical information should be edited out of the report of the inquiry into his care and treatment before it was published. He claimed publication would breach his right to privacy under article 8 of the European Convention on Human Rights, and his right to confidentiality under the Data Protection Act.

But at the High Court in London, Mr Justice Davis agreed with the South East …
SEROLOGICAL DIFFERENTIATION OF STERIC ISOMERS (ANTIGENS CONTAINING TARTARIC ACIDS)
Authors: K. Landsteiner, J. van der Scheer
Journal: The Journal of Experimental Medicine (1929)

In continuation of studies on the stereochemical specificity of serum reactions, antigens were examined containing the acyl radicals of the levo-, dextro-, and meso-tartaric acids. It was found that in this case also, immune sera can readily be obtained which differentiate sharply the three antigens identical in every other respect but possessing stereoisomeric groups. Since the tartaric acids by their chemical constitution belong to the same class of substances as sugar acids the results have a bearing upon the question of the specificity of natural antigens containing carbohydrates such as have been described by Avery and Heidelberger.
What the Bayesian framework has contributed to understanding cognition: Causal learning as a case study
Authors: Keith J. Holyoak, Hongjing Lu
Journal: Behavioral and Brain Sciences (2011)

Abstract The field of causal learning and reasoning (largely overlooked in the target article) provides an illuminating case study of how the modern Bayesian framework has deepened theoretical understanding, resolved long-standing controversies, and guided development of new and more principled algorithmic models. This progress was guided in large part by the systematic formulation and empirical comparison of multiple alternative Bayesian models.
Contribution of smoking during pregnancy to inequalities in stillbirth and infant death in Scotland 1994-2003: retrospective population based study using hospital maternity records
Authors: R. Gray, S. R Bonellie, J. Chalmers, I. Greer, S. Jarvis, J. J Kurinczuk, C. Williams
Journal: BMJ (2009)

To quantify the contribution of smoking during pregnancy to social inequalities in stillbirth and infant death.Population based retrospective cohort study.Scottish hospitals between 1994 and 2003.Records of 529 317 singleton live births and 2699 stillbirths delivered at 24-44 weeks' gestation in Scotland from 1994 to 2003.Rates of stillbirth and infant, neonatal, and post-neonatal death for each deprivation category (fifths of postcode sector Carstairs-Morris scores); contribution of smoking during pregnancy ("no," "yes," or "not known") in explaining social inequalities in these outcomes.The stillbirth rate increased from 3.8 per 1000 in the least deprived group to 5.9 per 1000 in the most deprived group. For infant deaths, the rate increased from 3.2 per 1000 in the least deprived group to 5.4 per 1000 in the most deprived group. Stillbirths were 56% more likely (odds ratio 1.56, 95% confidence interval 1.38 to 1.77) and infant deaths were 72% more likely (1.72, 1.50 to 1.97) in the most deprived compared with the least deprived category. Smoking during pregnancy accounted for 38% of the inequality in stillbirths and 31% of the inequality in infant deaths.Both tackling smoking during pregnancy and reducing infants' exposure to tobacco smoke in the postnatal environment may help to reduce stillbirths and infant deaths overall and to reduce the socioeconomic inequalities in stillbirths and infant deaths perhaps by as much as 30-40%. However, action on smoking on its own is unlikely to be sufficient and other measures to improve the social circumstances, social support, and health of mothers and infants are needed.
G8 leaders must seize their chance to tackle undernutrition
Authors: M. A. Ayoya
Journal: BMJ (2010)

The world continues to fail malnourished children and hence stalls any progress in achieving the United Nations’ millennium development goals to halve hunger and reduce child mortality by two thirds between 1990 and 2015.

We know that between 3.5 million and five million children aged under 5 years die every year because of undernutrition and that low birth weight is responsible for 3.3% of overall child mortality.1 Initiation of breast feeding within one hour of birth, exclusive breast feeding for the first six months, and continued breast feeding for two years or beyond—together with age appropriate, nutritionally adequate complementary foods—have the potential to prevent 19% of all deaths of under 5s in the developing world.

Providing vitamin A supplements twice a year to all children aged 6 months to 59 months can avert …
Sleep-Disordered Breathing and Cognitive Impairment in Older Women
Authors: D. Gianakos, A. Mehra
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NOTE ON HEPATIC INSUFFICIENCY
Authors: H. A. Harris
Journal: BMJ (1932)

rmEDICAL JOURNAL~H epatic function is impaired so little that there is good comparison with ether and the barbiturates.Even when a liver has been purposely damaged by chloroform, avertin causes very little additional impediment.More may be said about the liver in its activity.During anaesthesia phosphoric acid appears to leave the muscles and to sojourn in that gland until the resumption of kidney function after the recovery of an animal, when it is redistributed and partly excreted,'6 and Mann"7 has given it out that ether produces demonstrable effects on hepatic activity; it causes a hyperglycaemia dependent wholly on the liver, and it also d-epresses hepatic function in regard to the secretion of bile.These informative data could easily be amplified: how- evtr, they imay be sufficient for the presenit, and this fact remains,, that we should not decry any one drug too much.I am convinced that even chloroform has a definite place in anaesthesia.
The Damocles Syndrome: Psychosocial Consequences of Surviving Childhood Cancer
Authors: Alvin M. Mauer
Journal: JAMA (1981)

In the foreword to this excellent book, Dr Leon Eisenberg indicates that the psychological dilemma in childhood cancer has changed from one of adaptation to the imminence of death to a position of needing to cope with uncertain survival. This uncertainty for the child and family is likened to the sword of Damocles from the story told by Cicero. In this clearly written book, Drs Koocher and O'Malley relate the results of a study begun in 1975. The study was designed to assess the nature and incidence of psychosocial consequences among childhood cancer survivors and their families. As a consequence of this study they hoped to make recommendations for the care of patients to reduce long-term psychological problems apparent from their study. The subjects chosen for this study had survived for more than five years malignancies that had been diagnosed before the age of 18 years. These survivors had been
PTU-266 Trainee satisfaction with JAG e-certification
Authors: S Dharmasiri, C Wells, L Flexer, S Thomas-Gibson, P Dunckley
Journal: Gut (2012)

<h3>Introduction</h3> In March 2011 JAG launched e-certification allowing trainees to apply for JAG certification through their JETS e-portfolio. Prior to this, trainees were required to submit paper portfolios for application of JAG certification. We report results of a quality assurance survey, which all trainees applying through the JETS e-portfolio were invited to complete. <h3>Methods</h3> All trainees applying through the JETS e-portfolio were invited to complete an online survey, created to assess trainee experience of e-certification. Trainees were asked if they strongly agreed (SA), agreed (A), were neutral (N), disagreed (D) or strongly disagreed (SD) with statements describing their experience of the process. <h3>Results</h3> A total of 109 applications for JAG certification have been made through the JETS e-portfolio since its launch. Some trainees have submitted more than one application for certification in different endoscopic modalities. A total of 33 trainees (30% of applications) completed the survey, 7 (21%) of which had previously applied for JAG certification by the paper or hybrid (paper and e-portfolio) methods. When questioned about the general process 69.2% agreed and 23.1% strongly agreed that it was better that the previous JAG certification process it replaced. The majority felt that the process was quicker (SA=42.9%, A=42.9%) and less time consuming (SA=28.6%, A=57.1%). Opinion was divided on cost; 48.5% agreed that the cost was reasonable and 15.2% were neutral but 30.3% disagreed and 6.1% strongly disagreed. The majority felt that a breakdown of costs would be helpful (SA=18.2%, A=51.5%, N=21.2%, D=9.1%). Trainees agreed that the process tested endoscopic competence across all the modalities: gastroscopy (SA=37.9%, A=62.1%), flexible sigmoidoscopy (SA=60%, A=40%) and colonoscopy (SA=44.4%, A=55.6%). There was agreement that the summative assessments were straightforward to submit (SA=48.4%, A=51.6%) and intuitive (SA=32.3%, A=58.1%, N=9.7%). Similarly trainees felt that the process of submitting the application by the JETS e-portfolio was straightforward (SA=42.4%, A=54.5%, N=3%), quick (SA=39.4%, A=54.5%, N=3%, D=3%) and that they were kept informed of their application progress (SA=45.5%, A=45.5%, N=9.1%). <h3>Conclusion</h3> This survey of trainee experience with the JETS e-portfolio application for JAG certification shows that trainees prefer the process compared to the old paper system. It is quicker and trainees agreed the process tested endoscopy competence in gastroscopy, colonoscopy and flexible sigmoidoscopy. The opinion of trainees regarding the cost of the process was spit and trainees would find a breakdown of the cost helpful. The findings of this survey show that the new e-portfolio certification functions well and meets the needs of trainees. <h3>Competing interests</h3> None declared.
Factors Affecting Interpretation of Postprandial Glucose and Insulin Areas
Authors: Mary C Gannon, Frank Q Nuttall
Journal: Diabetes Care (1987)

Recently there has been an increased interest in determining the circulating glucose concentration after the ingestion of various individual foods and mixed meals. The purpose of these determinations is to systematically rank foods with respect to their quantitative effect on postmeal glucose concentration. Potentially such data could be useful in designing a diet for individuals with diabetes. We believe this concept is good. However, several factors that may affect interpretation of the data used to develop this ranking need to be considered before the utility of this approach to dietary management can be assessed: 1) duration of time over which the data are collected and analyzed; 2) use of absolute versus incremental areas in the determinations; 3) inclusion or exclusion of negative areas if incremental areas are used; 4) differences in response to a given food in males compared with females; 5) severity of diabetes; 6) confounding effects of oral agents or insulin treatment; 7) reproducibility of data; 8) differences in collection of blood sample; 9) food composition, processing, and preparation; 10) the dose-response relationship to ingestion of a given carbohydrate; 11) the meal being studied, i.e., first, second, or third meal of the day; and 12) a possible effect of the composition of the previous meal, if the response is tested to any meal other than the first meal of the day.