tbuckley/cabot-search huggingface dataset:
Myocardial infarct size can be estimated from serial plasma myoglobin measurements within 4 hours of reperfusion.
Authors: T Yamashita, S Abe, S Arima, K Nomoto, M Miyata, I Maruyama, H Toda, H Okino, Y Atsuchi, M Tahara
Journal: Circulation (1993)

BACKGROUND An early estimation of infarct size is useful for the appropriate early treatment of patients with acute myocardial infarction. We evaluated how early and how accurately infarct size could be estimated from serial plasma myoglobin (Mb) measurements in patients with successful reperfusion. METHODS AND RESULTS We measured plasma Mb and creatine kinase (CK) in 35 patients in whom reperfusion therapy was successfully performed. Blood samples were collected at 15-minute intervals for 2 hours after reperfusion, at 30-minute intervals for the subsequent 2 hours, and at 3-6-hour intervals until 52 hours after reperfusion. Plasma Mb was measured by a newly developed turbidimetric latex agglutination assay. Total Mb and CK release (sigma Mb, sigma CK) were calculated with a one-compartment model. The mean chord motion in the most hypokinetic 50% of the infarct-related artery territory was calculated from follow-up ventriculograms as an index of the severity of regional hypokinesis. There were significant correlations between sigma Mb and sigma CK (r = 0.89), between log sigma Mb and the severity of regional hypokinesis (r = -0.85), and between log sigma CK and the severity of regional hypokinesis (r = -0.74). The time required for the cumulative Mb release curves to reach a plateau was 64 +/- 28 minutes. An additional 53 +/- 14 minutes was required to calculate the disappearance rate constant of Mb, and 15 minutes was necessary for the assay. Therefore, the total time required for sigma Mb to be available was 132 +/- 40 minutes, significantly shorter than the time required for sigma CK, 24.3 +/- 9.1 hours (p &lt; 0.001). The infarct size could be estimated from the sigma Mb in 34 of 35 patients within 4 hours of reperfusion. CONCLUSIONS Infarct size can be estimated accurately 4 hours after reperfusion by calculating the sigma Mb in patients with successful reperfusion.
State Diabetes Programs Need Adapted Guidelines
Authors: Rebecca Voelker
Journal: JAMA (2011)

programs provide instruction in mental healthcare, and that this canbe incorporatedintopediatric training.Hesaidsuch programs need to place greater emphasis on simple rules for diagnosing mentalhealthconditionsandwhattypesofcare canbeofferedinapediatricsetting.“That would go a long way to improve the care ofchildrenwithmental illnessandreduce the variation in practice,” he said. While specialists will continue to serve as a safety net in the care of patients with more complicated mental illness, March noted that pediatricians must play a role even in the care of these patients—for example, by avoiding the use of antibiotics that have central nervous system effects in patients who are being treated for mental health conditions. “There’s no expectation that pediatricians should be able to manage complex psychiatric disease, but they need to be able to identify patients with these conditions and know how to arrange a referral and co-manage their care,” March said.