tbuckley/cabot-search huggingface dataset:
The Effectiveness of the Cognitive Behavioral Analysis System of Psychotherapy for Chronic Depression: A Randomized Controlled Trial
Authors: Jenneke E. Wiersma, Digna J.F. Van Schaik, Adriaan W. Hoogendorn, Jack J. Dekker, Hendrikus L. Van, Robert A. Schoevers, Marc B.J. Blom, Kristel Maas, Johannes H. Smit, James P. McCullough Jr., Aartjan T.F. Beekman, Patricia Van Oppen
Journal: Psychotherapy and Psychosomatics (2014)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; It is widely agreed that chronic depression is difficult to treat, knowledge about optimal treatment approaches is emerging. &lt;b&gt;&lt;i&gt;Method:&lt;/i&gt;&lt;/b&gt; A multisite randomized controlled trial was conducted comparing the cognitive behavioral analysis system of psychotherapy (CBASP), a psychotherapy model developed specifically to treat chronic depression (n = 67) with care as usual (CAU; evidence-based treatments, n = 72) over a period of 52 weeks, with 23 sessions on average, in 3 outpatient clinics in the Netherlands. In both arms algorithm-based pharmacotherapy was provided. Patients (aged 18-65) met criteria for a DSM-IV diagnosis of major depressive disorder with diagnostic specifiers (chronic, without interepisode recovery) or with co-occurring dysthymic disorder indicating a chronic course. The Inventory for Depressive Symptomatology (IDS) Self-Report was used as the primary outcome measure. Mixed-effects linear regression analysis was used to compare the changes on the IDS scores between CBASP and CAU. The IDS was administered before treatment, and after 8, 16, 32 and 52 weeks. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; At week 52, patients assigned to CBASP had a greater reduction of depressive symptoms compared to patients assigned to CAU (t = -2.00, p = 0.05). However, CBASP and CAU did not differ from each other on the IDS after 8 weeks (t = 0.49, p = 0.63), 16 weeks (t = -0.03, p = 0.98) and 32 weeks (t = -0.17, p = 0.86) of treatment. &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; This trial shows that CBASP is at least as effective as standard evidence-based treatments for chronic depression. In the long run, CBASP appears to have an added effect.
Current Use of Unopposed Estrogen and Estrogen Plus Progestin and the Risk of Acute Myocardial Infarction Among Women With Diabetes
Authors: Assiamira Ferrara, Charles P. Quesenberry, Andrew J. Karter, Catherine W. Njoroge, Alice S. Jacobson, Joseph V. Selby
Journal: Circulation (2003)

Background— Little is known about hormone replacement therapy (HRT) and risk for myocardial infarction (MI) in diabetic women. We examined associations of current HRT, estrogen dosage, and time since HRT initiation with risk of acute MI in diabetic women. Methods and Results— Cox proportional hazards models, with current HRT modeled as a time-dependent covariate, were used to assess the 3-year risk of MI. Among 24 420 women without a recent MI (mean age 64.9 years), 1110 incident MIs were identified. After adjustment for cardiovascular risk factors, current HRT was associated with reduced MI risk (relative hazard [RH] 0.84, 95% CI 0.72 to 0.98). The RH for MI associated with current estrogen plus progestin use was 0.77 (95% CI 0.61 to 0.97), and the RH for MI associated with current unopposed estrogen use was 0.88 (95% CI 0.73 to 1.05). Women were at reduced MI risk if they were taking a low or medium dose of estrogen (equivalent to &lt;0.625 or 0.625 mg of conjugated estrogen, respectively) but not a high dose (&gt;0.625 mg of conjugated estrogen or its equivalent). Among those whose current use of HRT was &lt;1 year, the RH for MI was 1.03 (95% CI 0.74 to 1.44), whereas among users for ≥1 year, the RH was 0.81 (95% CI 0.66 to 1.00). Among 580 women with a recent MI (mean age 69.2 years), 89 recurrent MIs were identified. An increased risk of recurrent MI was observed among current HRT users (RH 1.78, 95% CI 1.06 to 2.98), which was higher among those with current use for &lt;1 year (RH 3.84, 95% CI 1.60 to 9.20). Conclusions— In women without a recent MI, use of estrogen plus progestin was associated with decreased risk of MI. However, HRT was associated with increased risk of MI in women with history of a recent MI. Data from clinical trials in diabetic women are needed.
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
Authors: Cameron R Stewart, Lynda M Stuart, Kim Wilkinson, Janine M van Gils, Jiusheng Deng, Annett Halle, Katey J Rayner, Laurent Boyer, Ruiqin Zhong, William A Frazier, Adam Lacy-Hulbert, Joseph El Khoury, Douglas T Golenbock, Kathryn J Moore
Journal: Nature Immunology (2009)
A multi-modality platform to image stem cell graft survival in the naïve and stroke-damaged mouse brain
Authors: Philipp Boehm-Sturm, Markus Aswendt, Anuka Minassian, Stefanie Michalk, Luam Mengler, Joanna Adamczak, Laura Mezzanotte, Clemens Löwik, Mathias Hoehn
Journal: Biomaterials (2013)

Neural stem cell implantations have been extensively investigated for treatment of brain diseases such as stroke. In order to follow the localization and functional status of cells after implantation noninvasive imaging is essential. Therefore, we developed a comprehensive multi-modality platform for in vivo imaging of graft localization, density, and survival using 19F magnetic resonance imaging in combination with bioluminescence imaging. We quantitatively analyzed cell graft survival over the first 4 weeks after transplantation in both healthy and stroke-damaged mouse brain and correlated our findings of graft vitality with the host innate immune response. The multi-modality imaging platform will help to improve cell therapy also in context other than stroke and to gain indispensable information for clinical translation.
Phasic vascular sodium pump changes in deoxycorticosterone-hypertensive rats.
Authors: E Songu-Mize, S L Bealer, R W Caldwell
Journal: Circulation Research (1984)

We determined the sodium pump activity, measured as ouabain-sensitive 86Rb+ uptake, in the tail arteries of rats treated with deoxycorticosterone and sodium chloride for 6, 9, 14, 28, and 50 days. Systolic blood pressures, plasma sodium, potassium, and creatinine concentrations were measured, and the body weights were recorded. Vascular sodium pump activity was suppressed (by 27%) at the 6th day of deoxycorticosterone and sodium chloride treatment, a prehypertensive state. By the 9th day, blood pressure of deoxycorticosterone-treated and sodium chloride rats had increased, but sodium pump activity was not different from that of control animals. However, increases in sodium pump activity were noted after 14 and 28 days of deoxycorticosterone and sodium chloride treatment (18 and 21%, respectively). By 28 days, a fully developed hypertension was noted. At 50 days, rats displayed lower vascular sodium pump activity (by 23%) than the controls. These rats, although hypertensive, had significantly lower systolic blood pressures than the rats treated for 28 days. They had high plasma creatinine levels, low potassium and sodium concentrations, and low body weights compared to the controls, suggesting the presence of a malignant state. Our data indicate that there are time-related changes in the vascular sodium pump activity with this type of hypertension.
Combination Therapy With Recombinant Human Granulocyte Colony‐Stimulating Factor and Erythropoietin in Aplastic Anemia
Authors: Masahiro Imamura, Masanobu Kobayashi, Sumiko Kobayashi, Kohki Yoshida, Chikara Mikuni, Yorikazu Ishikawa, Shuzo Matsumoto, Sumio Sakamaki, Yoshiro Niitsu, Yuji Hinoda, Akira Yachi, Tohru Kudoh, Shunzo Chiba, Masaharu Kasai, Toshiaki Oka, Akimasa Okuno, Isao Maekawa, Keisuke Sakurada, Tamotsu Miyazaki
Journal: American Journal of Hematology (1995)

Abstract Recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) and erythropoietin (rhEPO) were used to treat patients with aplastic anemia (AA). In terms of effects on erythrocyte recovery, the combined use of rhG‐CSF and rhEPO showed a favorable response in 6 of 14 (42.9%) patients with moderate AA following 10 weeks treatment and in 3 of 14 (21.4%) patients thereafter. However, the response was poor in patients with severe AA (3/13). A favorable response in severe AA was observed in 1 of 13 (7.7%) patients following 10 weeks treatment and in 2 of 13 (15.4%) patients thereafter. The overall effect on erythrocytes was observed in 44.4% patients. A dose of 400 μ/m 2 G‐CSF was sufficient to cause an increase in neutrophil count and 100 IU/kg rhEPO appeared to be sufficient to cause an increase in erythrocyte count. In 6 of 27 (22.2%) patients, a trilineage response was observed. Interestingly, a delayed and long‐lasting effect was obtained in 5 of 27 (18.5%) patients. These results suggest that rhG‐CSF can synergize with rhEPO in erythrocyte response, especially in patients with moderate AA.
Extrapulmonary Localization of Gallium in Sarcoidosis
Authors: PRASHANT K. ROHATGI, RAVINDER SINGH, FRANK VIERAS
Journal: Clinical Nuclear Medicine (1987)

This paper describes the spectrum of extrapulmonary localization of gallium in patients with sarcoidosis. The usefulness of Ga-67 scintiscans in detecting clinically occult lesions, in directing clinicians to accessible sites for biopsy, and in following the course of extrapulmonary sites of involvement with therapy is emphasized.
Promoter hypermethylation of the cyclin-dependent kinase inhibitor (CDKI) gene p21WAF1/CIP1/SDI1 is rare in various lymphomas and carcinomas
Authors: Jianming Ying, Gopesh Srivastava, Zifen Gao, Xiaohua Zhang, Paul Murray, Richard Ambinder, Qian Tao
Journal: Blood (2003)
PARAFFIN PAPER AS A SURGICAL DRESSING
Authors: CHARLES M. HARPSTER
Journal: JAMA (1918)

On account of the small supply and high cost of gauze, paraffin tissue paper will be found an excellent dressing for burns or any other condition in which a nonadherent dressing is desirable. It is far superior to the paraffin dressing of burns by the spray method, is much more easily and rapidly applied, results in more rapid healing of the burned surface, and is more easily removed. In the first stage of burns, when there is great pain, the various ointments now in use can be applied directly to the paraffin paper and this applied to the burned area after all vesicles have been opened. It has the advantage of excluding the air, which relieves the pain of the burns, and it is readily removed at the time of redressing, leaving the developing granulations unaltered. The first dressing, of pure petrolatum on paraffin paper, is applied directly to the
Opioids are commonly prescribed to women of reproductive age despite birth defect risk, US CDC study shows
Authors: M. McCarthy
Journal: BMJ (2015)

Although opioids are associated with serious birth defects, more than a third of US women of reproductive age who are enrolled in Medicaid and more than a quarter of those with private insurance fill in a prescription for opioid pain drugs each year, a study by the US Centers for Disease Control and Prevention (CDC) has shown.1

Half of pregnancies in the United States are unintended, the researchers noted, and many may go unrecognized during the …
Aplastic Anemia after Meprobamate (2-Methyl-2-N-Propyl-1,3-Propanediol Dicarbamate) Therapy
Authors: Leo M. Meyer, William L. Heeve, Robert W. Bertscher
Journal: New England Journal of Medicine (1957)

MEPROBAMATE (Miltown), 2-methyl-2-n-propyl-1,3-propanediol dicarbamate, was recently introduced as a sedative and tranquilizing drug. In doses of one or two tablets (400 mg. each) three times a day, no adverse hematologic effects were noted after two months.1 Rare allergic reactions were reported by Selling.2 More recently Carmel and Dannenberg3 described 3 cases of nonthrombocytopenic purpura after ingestion of 400 to 1200 mg.In the following case aplastic anemia developed after daily ingestion of 1200 mg. for eight days.Case ReportF.D., a 28-year-old woman, was admitted to the South Nassau Communities Hospital on May 13, 1956, because of malaise, weakness, headache . . .
[672] DETECTION OF ANTI-NUCLEAR PORE COMPLEX ANTIBODIES IN PRIMARY BlLlARY CIRRHOSIS: A COMPARISON BETWEEN WESTERN BLOT ANALYSIS AND INDIRECT IMMUNOFLUORESCENCE
Authors: M.S. Longhi, R.M. Mitry, G. Mieli-Vergani, D. Vergani, Y. Ma
Journal: Journal of Hepatology (2007)
Under the Tuscan sun
Authors: Kevin Barraclough
Journal: BMJ (2004)

T he heat in Tuscany is quite unlike that in England. In England, no matter how hot the day, there is always that hint of a chill—the merest echo that warns that summer is short and that winter, loaded with the passage of time, is not far away. Here the heat is like a blanket. It wraps away the anxieties of life in a cocoon of enforced idleness and fatigue.

Holidays do not come naturally to me and …
TV advertisement that linked alcohol with cancer was not misleading, says UK regulator
Authors: J. Gornall
Journal: BMJ (2014)

The UK Advertising Standards Authority has rejected complaints by the drinks industry that a hard hitting public health commercial depicting a tumour growing in a glass of beer was misleading and irresponsible.

Balance, an alcohol awareness organisation funded by the 12 local authorities in the north east of England, broadcast the television advertisement across the region for six weeks in November and December last year, to coincide with alcohol awareness week.



Courtesy of Balance North East

The advertisement featured a man taking sips from a glass of beer as he prepared a meal for his children. At the bottom of the glass was a small …
Differential influence of different dietary fatty acids on very low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants
Authors: Iliana López-Soldado, Michael Avella, Kathleen M. Botham
Journal: Metabolism (2009)

The influence of dietary fats carried in chylomicron remnants on the hepatic secretion of very low-density lipoprotein (VLDL) was investigated using chylomicron remnant-like particles (CRLPs) and cultured rat hepatocytes as the experimental model. Chylomicron remnant-like particles containing triacylglycerol (TG) from palm, olive, or corn (enriched in saturated, monounsaturated, or n-6 polyunsaturated fatty acids) oil, respectively, were incubated with cultured hepatocytes for 5 hours. The medium was then removed and replaced with medium without CRLPs; and the secretion of TG, cholesterol, and apolipoprotein B48 during the following 16 hours was determined. Secretion of TG into the d less than 1.050-g/mL fraction containing VLDL was unaffected by olive CRLPs, but was significantly increased in cells exposed to palm or corn CRLPs in comparison with both olive CRLPs and control incubations without CRLPs. Secretion of apolipoprotein B48, however, was not changed by any of the CRLP types. Apolipoprotein B messenger RNA levels were decreased by olive and corn CRLPs, and 3-hydroxy-3-methylglutaryl coenzyme A reductase messenger RNA abundance was increased by palm CRLPs; but expression of other genes involved in the regulation of VLDL secretion was unaffected. These findings demonstrate that CRLPs enriched in saturated fatty acids or n-6 polyunsaturated fatty acids increase the secretion of TG in VLDL, possibly because of the secretion of larger particles, whereas those enriched in monounsaturated fatty acids have no effect. Thus, different dietary fats have differential effects on VLDL secretion directly when delivered to the liver in chylomicron remnants.
Are limited opening times really to blame for men's underuse of healthcare services?
Authors: S. H. Walker
Journal: BMJ (2011)

<h3>ABSTRACT</h3> Evolutionary transitions to a social lifestyle in insects are associated with lineage-specific changes in gene expression, but the key nodes that drive these regulatory changes are largely unknown. We tested the hypothesis that changes in gene regulatory function associated with social evolution are facilitated by lineage-specific microRNA (miRNA) regulatory function. Genome scans across 12 bees showed that miRNA copy number is highly conserved and is not associated with variation in social organization. However, deep sequencing of small RNAs of six bee species revealed a substantial proportion (20-35%) of miRNAs are expressed in the brains of a single species, and many of these do not have identifiable homologs in any other species. Lineage-specific miRNAs disproportionately target lineage-specific genes, and have lower expression levels than more evolutionarily conserved miRNAs. Consistent with our hypothesis, the predicted targets of lineage-specific miRNAs are enriched for genes related to social behavior, such as caste-biased genes, in social species, but they are either not enriched for or significantly depleted of genes under positive selection. Together, these results suggest that novel miRNAs may contribute to lineage-specific patterns of molecular evolution associated with the origins and elaborations of eusociality. Our analyses also lend support to earlier hypotheses concerning miRNA origins from a relatively understudied taxonomic group, and reveal important differences in the evolution and assimilation of novel miRNAs between mammals and insects.
Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children
Authors: David K. Meyerholz, David A. Stoltz, Eman Namati, Shyam Ramachandran, Alejandro A. Pezzulo, Amanda R. Smith, Michael V. Rector, Melissa J. Suter, Simon Kao, Geoffrey McLennan, Guillermo J. Tearney, Joseph Zabner, Paul B. McCray, Michael J. Welsh
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Rationale: Although airway abnormalities are common in patients with cystic fibrosis (CF), it is unknown whether they are all secondary to postnatal infection and inflammation, which characterize the disease.Objectives: To learn whether loss of the cystic fibrosis transmembrane conductance regulator (CFTR) might affect major airways early in life, before the onset of inflammation and infection.Methods: We studied newborn CFTR−/− pig trachea, using computed tomography (CT) scans, pathology, and morphometry. We retrospectively analyzed trachea CT scans in young children with CF and also previously published data of infants with CF.Measurements and Main Results: We discovered three abnormalities in the porcine CF trachea. First, the trachea and mainstem bronchi had a uniformly small caliber and cross-sections of trachea were less circular than in controls. Second, trachealis smooth muscle had an altered bundle orientation and increased transcripts in a smooth muscle gene set. Third, submucosal gland units occurred with similar frequency in the mucosa of CF and control airways, but CF submucosal glands were hypoplastic and had global reductions in tissue-specific transcripts. To learn whether any of these changes occurred in young patients with CF, we examined CT scans from children 2 years of age and younger, and found that CF tracheas were less circular in cross-section, but lacked differences in lumen area. However, analysis of previously published morphometric data showed reduced tracheal lumen area in neonates with CF.Conclusions: Our findings in newborn CF pigs and young patients with CF suggest that airway changes begin during fetal life and may contribute to CF pathogenesis and clinical disease during postnatal life.
Etiologic Factors in Aortoiliac and Femoropopliteal Vascular Disease
Authors: Sandor A. Friedman, H. Edward Holling, Brooke Roberts
Journal: New England Journal of Medicine (1964)

IN 1940 Leriche1 described the following clinical features of obstruction of the terminal aorta: fatigue in hips, thighs or calves appearing after exertion; pallor of the legs on elevation; absence of arterial pulsations in the lower extremities; and inability to maintain a penile erection. He also commented on the slow progress of the syndrome and the rare occurrence ischemic skin lesions.A review of our experience with patients complaining of the effects of aortoiliac obstruction has led us to be dissatisfied with current accounts of what has come to be known as the Leriche syndrome. In the textbooks this . . .
THE KETOGENIC DIET
Authors: M. G. PETERMAN
Journal: JAMA (1928)

The ketogenic diet was introduced in 1924<sup>1</sup>after two years of clinical trial. Wilder,<sup>2</sup>in 1921, on the basis of Geyelin's<sup>3</sup>results with starvation, suggested that diets in which the proportion of carbohydrate and protein was sufficiently restricted might offer a method of treatment of epilepsy. It was on the basis of Wilder's suggestion that the high fat, low carbohydrate, restricted protein diet was evolved. Studies of patients on this diet and modifications of my original procedure have been reported during the past three years.<sup>4</sup>Other investigators have reported results in the treatment of epilepsy with the ketogenic diet but there have not been any modifications of my procedure,<sup>5</sup>nor have there appeared any other original explanations of the action of the diet in its control of epileptic seizures. In my preliminary report,<sup>1</sup>I suggested that the object of the diet was to produce
Advances in Reproductive Physiology
Authors: Charles W. Bodemer
Journal: JAMA (1968)

Advances in Teratology  , vol 2, edited by D. H. M. Woolam, 306 pp, with illus, $16, New York: Logos Press, Academic Press, Inc., 1967.  These books continue  annual series begun last year. Reproductive physiology and teratology represent inclusive disciplines which embrace an immense variety of subjects, and in bothAdvances in Reproductive PhysiologyandAdvances in Teratologythe editor has decided to include articles dealing with a variety of topics, rather than a central theme. Thus, volume 2 ofAdvances in Reproductive Physiologycontains material on behavior, the Physiology of Courtship and Mating  and Maternal Behavior in Rodents and Lagomorphs; items on  gametes and reproductive tract functions, Formation of  Egg in  Domestic Chicken, The Biochemical and Physiological Relationships Between  Gametes and  Female Reproductive Tract, The Action of Oestrogens, and The Hormonal Interplay Controlling Egg-Implantation in  Rat; and two articles discussing Growth of
Are Antidepressants Better Than Placebo?
Authors: SIDNEY MALITZ, MAUREEN KANZLER
Journal: American Journal of Psychiatry (1971)

A study of 203 depressed outpatients who were randomly assigned to one of seven active drug treatment groups or to a placebo group demonstrated that the inclusion of a placebo group is essential for valid assessment of the efficacy of antidepressant drugs. Although all groups improved on depression ratings in relation to their own baselines, only one group achieved a level of improvement that was significantly better than that of the placebo group.
Quality-of-Care Assessment by Process and Outcome Scoring
Authors: LISA RUBENSTEIN
Journal: Annals of Internal Medicine (1977)

Weighted process criteria based on chart review using an algorithmic method, and weighted outcome criteria based on a telephone interview with the patient, were used to assess the quality of emergency room care of women with symptoms of acute urinary tract infection. Outcomes at a municipal hospital were significantly better than those at an affiliated voluntary hospital. Process and outcome scores were positively correlated at both hospitals; the data suggest, but do not themselves adequately test, the hypothesis that the correlation is curvilinear and that there is a threshold process score below which a poor outcome is extremely likely. Our findings suggest that weighted algorithmic assessment criteria are a useful method for quality assessment and are consistent with the testable hypothesis that the greatest improvements in outcome may result from raising the quality of care from a poor to an adequate level rather than from an adequate to an optimal level.