tbuckley/cabot-search huggingface dataset:
The effect of endurance exercise on the power, speed, talent and anaerobic capacities of teenage female basketball players
Authors: Rüçhan İri, Gürkan Yılmaz, M Serdar Çözeli
Journal: British Journal of Sports Medicine (2010)

The aim of this study is to investigate a 16-week endurance exercise in terms of power, speed, ability and aerobic capacity in 13–16-year-old female basketball players. Twenty female basketball players participated in the study and they are divided into two groups, ‘endurance group’ and ‘control group’. Both groups have exercised 3 days a week and 90 min a day throughout 16 weeks. The 1st group (endurance group – EG) is applied the interval training method and the 2nd (control group – CG) group is applied general basketball exercises. The groups in the study have taken 20-m speed run, squat jump, countermovement jump and running-based anaerobic speed run tests both before and after the exercises. Paired-samples t test is done for arithmetical mean, SD and the evaluation between groups, and non-parametric test Mann–Whitney U test is done for the comparison of the two groups. Statistically, in the assessment of groups before exercises (EÖ) and after exercises (ES), a significant difference is found in terms of the number of shoots within the groups themselves, between EÖ and ES, and between the two groups being in favour of EG group. A significant difference in favour of EG group is found in valid shoot and group shuttle tests as well. Statistically significant differences in favour of EG group are also found in the assessment of ES in terms of all the running values of anaerobic speed test. It is seen that there is a significant difference in the fatigue index value of EG group in favour of ES. No statistically significant differences have been observed in the other tests. In conclusion, interval endurance exercise is seen to have caused an improvement in the number of shoots, in valid shoots, in grouped shuttle tests and in the anaerobic powers of young females. Thus, it can be suggested that the application of interval training method besides cardiovascular and metabolic specific factors in the improvement of endurance in children may be useful.
Prevention of Wound Dehiscence by Use of Stainless-Steel Retention Sutures
Authors: Thomas J. Anglem
Journal: JAMA (1961)

Through-and-through wire stay sutures of stainless steel were used to reinforce the closure of the abdominal incision in 835 patients, mostly after operations on the upper abdomen. In 893 other patients who had mostly lower abdominal incisions stay sutures were not used. In each of these 2 groups there were 3 cases of dehiscence. The incidence of this complication was about the same (0.36% and 0.33%) in the two groups. This is considered significant because several factors make for weakness of the abdominal wall after incisions in the upper abdomen. The results are therefore interpreted to mean that the stay sutures used for closure after upper abdominal operations appreciably reduced the danger of dehiscence.
Abstract 3221: Anticancer effect of PUFAs is mediated by inhibition of polyisoprenylated methylated protein methyl esterase
Authors: Felix Amissah, Lambert T. Ayuk-Takem, Nazarius S. Lamango
Journal: Cancer Research (2012)

Abstract Purpose: Polyisoprenylation is a set of secondary modifications involving proteins whose aberrant activities are implicated in cancers and macular degeneration. This process is essential for the activities of oncogenic proteins such as Ras. The terminal reversible step of polyisoprenylation pathway is catalyzed by an ester forming polyisoprenylated protein methyl transferase and polyisoprenylated methylated protein methyl esterase (PMPMEase). PUFAs share structural similarities with the polyisoprenyl groups and may interfere with polyisoprenylated protein metabolism. Methods: The effect of PUFAs on purified PMPMEase activity was studied. The inhibitory PUFAs were further evaluated on the viability of various cancer cell lines. The PMPMEase activity in the lysates of treated cells was analyzed in the presence or absence of COX-2/celecoxib. The mechanism of PUFAs-induced cell death was determined using a modified ethidium bromide and acridine orange (EB/AO) staining assay. Results: PUFAs such as arachidonic (AA), eicosapentaenoic and docosahexaenoic acids inhibited purified PMPMEase activity with Ki values of 0.12 to 3.7 µM. Enzyme kinetics analysis with PMPMEase revealed a 2- fold decrease in KM from 16.2 ± 1.34 to 8.60 ± 1.20 and 7.84 ± 1.02 μM in the presence of 10 μM AA or EPA, respectively. AA also induced the degeneration of various cancer cells at physiologically relevant concentrations (EC50 from 1 to 24 μM). The cellular PMPMEase activity also followed similar profiles to those of the cell viabilities in concentration-dependent studies. Treated degenerating cells displayed diminished PMPMEase activities. The inhibited PMPMEase activities in PUFAs-treated cells were restored by the addition of COX-2 but not in the presence of celecoxib. Conclusions: These data suggest that AA and other PUFAs, functioning through PMPMEase inhibition, may be involved in the regulation of cell proliferation. NSAIDs may thus owe their anticancer effects by protecting the PMPMEase- and cell proliferation-inhibiting PUFAs from COX-2 metabolism. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3221. doi:1538-7445.AM2012-3221
Weaver's Bottom
Authors: C. Russell Anderson
Journal: JAMA (1974)

<h3>To the Editor.—</h3> I have just read "Ischiogluteal Bursitis: The Pain in the Arse" (227:551, 1974) by Swartout and Compere. This syndrome, ischiogluteal bursitis (weaver's bottom), has been described in several editions of<i>Christopher's Minor Surgery</i>(Philadelphia, W. B. Saunders Co). Ischiogluteal bursitis is one of the manifestations of gout and responds to treatment with colchicine, an opiate, and uricosuric drugs. It is well to remember that gout may affect any joint or bursa. I remember because I suffer from gout, and I have sat on weaver's bottom!
Correction: Plasma Exchange When Myeloma Presents as Acute Renal Failure
Authors: William F. Clark
Journal: Annals of Internal Medicine (2007)

Letters20 March 2007Correction: Plasma Exchange When Myeloma Presents as Acute Renal FailureWilliam F. Clark, MDWilliam F. Clark, MDFrom London Health Sciences Center, London, Ontario N6A 4G5, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-6-200703200-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: We are submitting a new Table 2 to replace the original Table 2 that appeared in our article (1). We discovered an error in the order of data entry in the original table. The control group (no plasma exchange group) was compared with the plasma exchange group instead of the plasma exchange group being compared with the control group. This error has no effect on the interpretation or conclusions of the paper. In the original Table 2, the primary composite outcome occurred more frequently in the control group than in the plasma exchange group. Thus, when comparing ...Reference1. Clark WF, Stewart AK, Rock GA, Sternbach M, Sutton DM, Barrett BJ, et al. Plasma exchange when myeloma presents as acute renal failure: a randomized, controlled trial. Ann Intern Med. 2005;143:777-84. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From London Health Sciences Center, London, Ontario N6A 4G5, Canada.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPlasma Exchange When Myeloma Presents as Acute Renal Failure William F. Clark , A. Keith Stewart , Gail A. Rock , Marion Sternbach , David M. Sutton , Brendan J. Barrett , A. Paul Heidenheim , Amit X. Garg , David N. Churchill , and Metrics Cited ByThe Clone Wars: Diagnosing and Treating Dysproteinemic Kidney Disease in the Modern EraPerspectives From an Onconephrology Interest Group: Conference ReportSupportive Care in Multiple MyelomaRenal, GI, and Peripheral Nerves: Evidence-Based Recommendations for the Management of Symptoms and Care for Patients With Multiple MyelomaMyelosuppression, Bone Disease, and Acute Renal Failure: Evidence-Based Recommendations for Oncologic EmergenciesDysproteinemias and Kidney DiseaseMyeloma-related Kidney DiseaseImplementation and Assessment of a Resident Curriculum in Evidence-Based Transfusion Medicine 20 March 2007Volume 146, Issue 6Page: 471KeywordsAcute renal failureBlood plasmaConflicts of interestMultiple myelomaMyeloma ePublished: 20 March 2007 Issue Published: 20 March 2007 CopyrightCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Puppy Love Can Be Therapeutic, Too
Authors: Rebecca Voelker
Journal: JAMA (1995)

ON A WINTRY November night, a special group of therapists makes its way to the 11th floor of the Rehabilitation Institute of Chicago (Ill). They arrive with cold noses, but that has nothing to do with the blustery weather. These therapists have names like Max, Kelly, Derby, and Jake. Each has four legs and a gorgeous fur coat. "The dogs are a source of inspiration," says Marquette Buie, recovering from multiple gunshot wounds that in September 1994 left him quadriplegic. Since then, Buie has regained the use of his right arm and hand and his ability to speak. He says that the dogs, which arrive with their owners weekly at the institute through a volunteer-based animal-assisted therapy program, play a role in his recovery. "When I was hurting and thought I couldn't go on, I'd come to see these dogs." By giving them verbal commands, Buie relearned how to project
Use of branched chain amino acids for treating hepatic encephalopathy: clinical experiences.
Authors: F Rossi Fanelli, C Cangiano, L Capocaccia, A Cascino, F Ceci, M Muscaritoli, G Giunchi
Journal: Gut (1986)

The efficacy of branched chain amino acids in two consecutive clinical studies in patients with severe hepatic encephalopathy was tested. In the preliminary uncontrolled study 19 patients with grade 3-4 hepatic encephalopathy were given an intravenous solution containing leucine 11 g/l, isoleucine 9 g/l, and valine 8.4 g/l in 20% dextrose. A complete recovery of mental state was obtained in all patients in a mean time of 20.5 hours. In a subsequent controlled study 40 patients with grade 3-4 hepatic encephalopathy were randomly assigned to receive intravenous branched chain amino acid in 20% dextrose (group A) or oral lactulose (group B). Twelve patients (70.6%) in group A and eight (47%) in group B regained consciousness in a mean time of 27.6 and 31.5 hours, respectively. The difference in the recovery rate between the two groups, although evident, was not significant. Intravenous branched chain amino acids are thus at least as effective as lactulose in reversing hepatic coma. These data argue strongly in favour of a therapeutic effect of branched chain amino acids in the treatment of hepatic encephalopathy in patients with chronic liver failure.
Outcomes of elective surgery undertaken in independent sector treatment centres and NHS providers in England: audit of patient outcomes in surgery
Authors: J. Chard, M. Kuczawski, N. Black, J. van der Meulen
Journal: BMJ (2011)

<b>Objective</b> To compare characteristics of patients and outcomes after elective surgery in independent sector treatment centres (ISTCs) and NHS providers. <b>Design</b> Follow-up study with outcomes reported by patients three to six months after surgery. <b>Setting</b> 25 ISTCs and 72 NHS providers in England. <b>Population</b> Consecutive patients undergoing hip or knee replacement (5671 in ISTCs and 14 292 in NHS), inguinal hernia repair (640 and 2023, respectively), or surgery for varicose veins (248 and 1336, respectively). <b>Main outcomes</b> Symptoms and disability reported by patients (Oxford hip and knee scores on a 48 point scale; Aberdeen varicose vein questionnaire) and quality of life (EuroQol EQ-5D score). <b>Results</b> Patients in ISTCs were healthier than those in NHS providers, had less severe preoperative symptoms, and were more affluent, though the differences were small. With adjustment, patients undergoing joint replacements in NHS providers had poorer outcomes: difference of −1.7 (95% confidence interval −2.5 to −0.9) on the Oxford hip score and −0.9 (−1.6 to −0.2) on the Oxford knee score. They more often reported complications: odds ratio 1.3 (95% confidence interval 1.1 to 1.5) for hip and 1.4 (1.2 to 1.6) for knee. There were no significant differences in outcomes after surgery for hernia or varicose veins, except that NHS patients more often reported poor results after hernia repair (1.4, 1.0 to 1.9) and additional surgery after varicose vein surgery (2.8, 1.2 to 6.8). <b>Conclusion</b> Patients undergoing surgery in ISTCs were slightly healthier and had less severe conditions than those undergoing surgery in NHS providers. Some outcomes were better in ISTCs, but differences were small compared with the impact ISTCs could have on the provision of elective services.
Staphylococcal SSL5 inhibits leukocyte activation by chemokines and anaphylatoxins
Authors: Jovanka Bestebroer, Kok P. M. van Kessel, Hafida Azouagh, Annemiek M. Walenkamp, Ingrid G. J. Boer, Roland A. Romijn, Jos A. G. van Strijp, Carla J. C. de Haas
Journal: Blood (2008)
Spurious Reporting of Nocturnal Hypoglycemia by CGMS in Patients With Tightly Controlled Type 1 Diabetes
Authors: Kilty McGowan, William Thomas, Antoinette Moran
Journal: Diabetes Care (2002)

OBJECTIVE—The Medtronic MiniMed Continuous Glucose Monitoring System (CGMS) is designed to continuously monitor interstitial fluid glucose levels within a range of 40–400 mg/dl. It is considered an important tool for overnight glucose monitoring. The goal of this study was to determine the accuracy of this system in individuals with tightly controlled diabetes. RESEARCH DESIGN AND METHODS—Seven adolescents and young adults with HbA1c levels 6.6 ± 0.6% (range 5.7–7.1) were admitted to the Clinical Research Center. Simultaneous glucose measurements obtained by glucose analyzer, Accu-Check Advantage meter, and CGMS were compared. The analyzer levels were considered the standard. RESULTS—The CGMS results were lower than analyzer readings in 74% of simultaneous pairs of tests performed during the 24-h period; the average correlation was 0.76. There was a trend for the poorest correlation to occur in patients with the narrowest range in daily glucose levels. When the lowest CGMS reading of the night was compared with the simultaneous analyzer reading, the CGMS level was lower in all cases by an average of 38 ± 15%. In six of seven patients, the discrepancy was believed to be clinically significant; in at least four patients, overnight glucose levels reported by CGMS were falsely low, in a range that might have resulted in inappropriate reduction of overnight insulin dose. CONCLUSIONS—CGMS reports of asymptomatic nighttime hypoglycemia may be spurious and should be interpreted with caution in patients with tightly controlled diabetes.
Long-Term Clinical Outcome After Fractional Flow Reserve–Guided Treatment in Patients With Angiographically Equivocal Left Main Coronary Artery Stenosis
Authors: Michalis Hamilos, Olivier Muller, Thomas Cuisset, Argyrios Ntalianis, Gregory Chlouverakis, Giovanna Sarno, Olivier Nelis, Jozef Bartunek, Marc Vanderheyden, Eric Wyffels, Emanuele Barbato, Guy R. Heyndrickx, William Wijns, Bernard De Bruyne
Journal: Circulation (2009)

Significant left main coronary artery stenosis is an accepted indication for surgical revascularization. The potential of angiography to evaluate the hemodynamic severity of a stenosis is limited. The aims of the present study were to assess the long-term clinical outcome of patients with an angiographically equivocal left main coronary artery stenosis in whom the revascularization strategy was based on fractional flow reserve (FFR) and to determine the relationship between quantitative coronary angiography and FFR.In 213 patients with an angiographically equivocal left main coronary artery stenosis, FFR measurements and quantitative coronary angiography were performed. When FFR was > or =0.80, patients were treated medically or another stenosis was treated by coronary angioplasty (nonsurgical group; n=138). When FFR was <0.80, coronary artery bypass grafting was performed (surgical group; n=75). The 5-year survival estimates were 89.8% in the nonsurgical group and 85.4% in the surgical group (P=0.48). The 5-year event-free survival estimates were 74.2% and 82.8% in the nonsurgical and surgical groups, respectively (P=0.50). Percent diameter stenosis at quantitative coronary angiography correlated significantly with FFR (r=-0.38, P<0.001), but a very large scatter was observed. In 23% of patients with a diameter stenosis <50%, the left main coronary artery stenosis was hemodynamically significant by FFR.In patients with equivocal stenosis of the left main coronary artery, angiography alone does not allow appropriate individual decision making about the need for revascularization and often underestimates the functional significance of the stenosis. The favorable outcome of an FFR-guided strategy suggests that FFR should be assessed in such patients before a decision is made "blindly" about the need for revascularization.
Hybrid acute leukemia in an HIV-antibody-positive patient
Authors: Jay E. Gold, Arvid Babu, Victor Penchaszadeh, Antonio Castella, Violette Ghali, Ralph Zalusky
Journal: American Journal of Hematology (1989)

Abstract Although the great majority of acute leukemias have been designated as being of lymphocytic or myelocytic origin, recent reports have described elements of both in some patients. We describe here the first case of hybrid acute leukemia in an HIV‐antibody‐positive patient as well as the first hybrid involving B‐cell (Burkitt) acute lymphocytic leukemia and acute myelomonocytic leukemia proven by cytochemical, immunologic, and cytogenetic methods. This case illustrates the increasingly complex difficulties in the diagnosis and treatment of AIDS‐related malignancies.
Interferon- release assays for diagnosis of active pleural tuberculosis: a developing world perspective
Authors: K. Shah, Z. Udwadia
Journal: European Respiratory Journal (2011)

smoke or nitrogen dioxide exposure, in an analysis analagous to that presented in our article, no such synergy is apparent.Again, given the limited sample size and specific context of our analysis, no definitive conclusion can be drawn from these results, but it is possible that dog/endotoxin may synergise more powerfully with indoor air pollutants, relative to other exposures.If so, it may be important to understand the biology that underlies this effect.
Cortisol, Testosterone, and Coronary Heart Disease
Authors: George Davey Smith, Yoav Ben-Shlomo, Andrew Beswick, John Yarnell, Stafford Lightman, Peter Elwood
Journal: Circulation (2005)

There is a popular belief that chronic stress causes heart disease through psychoneuroendocrine mechanisms. We have examined whether an elevated circulating cortisol-to-testosterone ratio increases the risk of ischemic heart disease.We undertook a prospective cohort study of 2512 men aged 45 to 59 years between 1979 and 1983 from Caerphilly, South Wales, with a mean follow-up of 16.5 years. Subjects underwent a clinical examination, and morning fasting blood samples were taken for analysis of cortisol levels, testosterone levels, and other cardiovascular risk factors. The ratio of cortisol to testosterone showed weak associations with potential confounding factors but strong positive associations with components of the insulin resistance syndrome (P<0.001). A positive linear trend was seen across quintiles of cortisol:testosterone ratio for incident ischemic heart disease (age-adjusted OR per z score change in ratio 1.22, 95% CI 1.07 to 1.38, P=0.003). This was markedly attenuated after adjustment for components of the insulin resistance syndrome (age-adjusted OR per z score change in ratio 1.10, 95% CI 0.96 to 1.25, P=0.18). There was no association between the cortisol:testosterone ratio and other causes of death (age-adjusted hazard ratio 0.99, 95% CI 0.88 to 1.11, P=0.81).This is the first population-based prospective study that has found a specific association between cortisol:testosterone ratio and incident ischemic heart disease, apparently mediated through the insulin resistance syndrome. Whether this reflects the effects of chronic stress, behavioral factors, or genetic influences remains to be determined.
Mortality after the Hospitalization of a Spouse
Authors: Nicholas A. Christakis, Paul D. Allison
Journal: New England Journal of Medicine (2006)

The illness of a spouse can affect the health of a caregiving partner. We examined the association between the hospitalization of a spouse and a partner's risk of death among elderly people.We studied 518,240 couples who were enrolled in Medicare in 1993. We used Cox regression analysis and fixed-effects (case-time-control) methods to assess hospitalizations and deaths during nine years of follow-up.Overall, 383,480 husbands (74 percent) and 347,269 wives (67 percent) were hospitalized at least once, and 252,557 husbands (49 percent) and 156,004 wives (30 percent) died. Mortality after the hospitalization of a spouse varied according to the spouse's diagnosis. Among men, 6.4 percent died within a year after a spouse's hospitalization for colon cancer, 6.9 percent after a spouse's hospitalization for stroke, 7.5 percent after a spouse's hospitalization for psychiatric disease, and 8.6 percent after a spouse's hospitalization for dementia. Among women, 3.0 percent died within a year after a spouse's hospitalization for colon cancer, 3.7 percent after a spouse's hospitalization for stroke, 5.7 percent after a spouse's hospitalization for psychiatric disease, and 5.0 percent after a spouse's hospitalization for dementia. After adjustment for measured covariates, the risk of death for men was not significantly higher after a spouse's hospitalization for colon cancer (hazard ratio, 1.02; 95 percent confidence interval, 0.95 to 1.09) but was higher after hospitalization for stroke (hazard ratio, 1.06; 95 percent confidence interval, 1.03 to 1.09), congestive heart failure (hazard ratio, 1.12; 95 percent confidence interval, 1.07 to 1.16), hip fracture (hazard ratio, 1.15; 95 percent confidence interval, 1.11 to 1.18), psychiatric disease (hazard ratio, 1.19; 95 percent confidence interval, 1.12 to 1.26), or dementia (hazard ratio, 1.22; 95 percent confidence interval, 1.12 to 1.32). For women, the various risks of death after a spouse's hospitalization were similar. Overall, for men, the risk of death associated with a spouse's hospitalization was 22 percent of that associated with a spouse's death (95 percent confidence interval, 17 to 27 percent); for women, the risk was 16 percent of that associated with death (95 percent confidence interval, 8 to 24 percent).Among elderly people hospitalization of a spouse is associated with an increased risk of death, and the effect of the illness of a spouse varies among diagnoses. Such interpersonal health effects have clinical and policy implications for the care of patients and their families.