External Pancreatic Secretion in Diabetes Mellitus
Authors: WOO YOON CHEY
Journal: Annals of Internal Medicine (1963)

Article1 December 1963External Pancreatic Secretion in Diabetes MellitusWOO YOON CHEY, M.D., HARRY SHAY, M.D., F.A.C.P., CHARLES R. SHUMAN, M.D., F.A.C.P.WOO YOON CHEY, M.D., HARRY SHAY, M.D., F.A.C.P., CHARLES R. SHUMAN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-812 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhether changes in external pancreatic secretion can occur in diabetes mellitus has long been debated. Early investigators, using a single lumen (1) or a double lumen tube (2-4) for the collection of duodenal contents after pancreatic stimulation, reported abnormalities in external pancreatic secretion in some patients with diabetes mellitus. Others, however, concluded that diabetes mellitus per se does not cause an abnormal external pancreatic secretion and considered such findings to be due to either associated pancreatitis or tumor of the pancreas (5-6). In the present investigation, we studied external secretory function of pancreas after the injection of pancreozymin and secretin...References1. JONESCASTLEMULHOLLANDBAILEY CMWBHBF: Pancreatic hepatic activity in diabetes mellitus. Arch. Intern. Med. (Chicago) 35: 315, 1925. CrossrefGoogle Scholar2. LAGERLÖF H: The secretin test of pancreatic function. Quart. J. Med., N.S. 8: 115, 1939. Google Scholar3. DIAMONDSIEGEL JSSA: The secretin test in the diagnosis of pancreatic disease with a report of one hundred and thirty test. Amer. J. Dig. Dis. 7: 435. 1940. CrossrefGoogle Scholar4. POLLARDMILLERBREWER HMLWA: The external secretion of the pancreas and diabetes mellitus. Amer. J. Dig. Dis. 10: 20, 1943. CrossrefGoogle Scholar5. DREILING DA: Studies in pancreatic function. IV. The use of secretin test in the diagnosis of tumors and about the pancreas. Gastroenterology 18: 184, 1951. CrossrefMedlineGoogle Scholar6. AKTANKLOTZ HSAP: Fat absorption and pancreatic function in diabetes mellitus. Ann. Intern. Med. 49: 820, 1958. LinkGoogle Scholar7. FISHERYATES RAF: Statistical Tables for Biological, Agricultural and Medical Research, Oliver and Body, London, 1948, p. 104. Google Scholar8. SUNSHAY DCH: Pancreozymin-secretin test, the combined study of serum enzymes and duodenal contents in the diagnosis of pancreatic disease. Gastroenterology 38: 570, 1960. CrossrefMedlineGoogle Scholar9. JOSLINROOTWHITEMARBLE EPHEPA: The Treatment of Diabetes Mellitus, 10th Ed., Lea and Febiger, Philadelphia, 1959, p. 656. Google Scholar10. WARRENLECOMPTE SPM: The Pathology of Diabetes Mellitus. Lea and Febiger, Philadelphia, 1952, p. 63. Google Scholar11. GIBBLOGAN WFVW: Diabetes mellitus, a study of one hundred forty-seven autopsies. Arch. Intern. Med. (Chicago) 43: 376, 1929. CrossrefGoogle Scholar12. VARTIAINEN I: Studien über den diabetes mellitus in Finland; die makroscopischen Organveränderungen der Diabetiker in Lichte des Obduktionsmaterials. Acta Med. Scand. 118: 538, 1944. CrossrefGoogle Scholar13. MACLEANOGILVIE NRF: Quantitative estimation of the pancreatic islet tissue in diabetic subjects. Diabetes 4: 367, 1955. CrossrefMedlineGoogle Scholar14. TULLYLOWENTHAL GTJJ: The diabetic coma of acute pancreatitis. Ann. Intern. Med. 48: 310, 1958. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom Fels Research Institute and Department of Medicine, Temple University Medical Center, Philadelphia, Pennsylvania.Requests for reprints should be addressed to Woo Yoon Chey, M.D., Fels Research Institute, Temple University School of Medicine, Philadelphia 40, Pennsylvania.Dr. Shay died on July 30, 1963. 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VACCA, M.D., F.A.C.P., WILBERT J. HENKE, M.D., WILLIAM A. KNIGHT JR., M.D., F.A.C.P. 1 December 1963Volume 59, Issue 6Page: 812-821KeywordsAcute pancreatitisChronic pancreatitisDiabetes mellitusInsulin secretionLipasesPancreasPancreatitisSecretin Issue Published: 1 December 1963 PDF DownloadLoading ...