tbuckley/cabot-search huggingface dataset:
Vascularization and restoration of heart function in rat myocardial infarction using transplantation of human cbMSC/HUVEC core-shell bodies
Authors: Wen-Yu Lee, Hao-Ji Wei, Jiun-Jie Wang, Kun-Ju Lin, Wei-Wen Lin, Ding-Yuan Chen, Chieh-Cheng Huang, Ting-Yin Lee, Hsiang-Yang Ma, Shiaw-Min Hwang, Yen Chang, Hsing-Wen Sung
Journal: Biomaterials (2011)
THE DIAGNOSTIC VALIDITY OF THE RORSCHACH TEST
Authors: John D. Benjamin, Franklin G. Ebaugh
Journal: American Journal of Psychiatry (1938)

1. Previous attempts to investigate the reliability and validity of the Rorschach test by means of statistical methods are criticized. 2. In a series of 50 cases the Rorschach diagnosis is compared with the clinical diagnosis. 3. The results of the investigation show that the Rorschach test possesses a high degree of diagnostic validity.
REDUCED LEFT VENTRICULAR GLOBAL LONGITUDINAL STRAIN IN HEART TRANSPLANT RECIPIENTS IS ASSOCIATED WITH AN INCREASED ONE YEAR MORTALITY
Authors: Sebastian I. Sarvari, Ola Gjesdal, Einar Gude, Satish Arora, Kristina H. Haugaa, Arne K. Andreassen, Lars Gullestad, Odd R. Geiran, Thor Edvardsen
Journal: Journal of the American College of Cardiology (2011)
LPS-induced down-regulation of signal regulatory protein α contributes to innate immune activation in macrophages
Authors: Xiao-Ni Kong, He-Xin Yan, Lei Chen, Li-Wei Dong, Wen Yang, Qiong Liu, Le-Xing Yu, Dan-Dan Huang, Shu-Qin Liu, Hui Liu, Meng-Chao Wu, Hong-Yang Wang
Journal: The Journal of Experimental Medicine (2007)

Activation of the mitogen-activated protein kinases (MAPKs) and nuclear factor κB (NF-κB) cascades after Toll-like receptor (TLR) stimulation contributes to innate immune responses. Signal regulatory protein (SIRP) α, a member of the SIRP family that is abundantly expressed in macrophages, has been implicated in regulating MAPK and NF-κB signaling pathways. In addition, SIRPα can negatively regulate the phagocytosis of host cells by macrophages, indicating an inhibitory role of SIRPα in innate immunity. We provide evidences that SIRPα is an essential endogenous regulator of the innate immune activation upon lipopolysaccharide (LPS) exposure. SIRPα expression was promptly reduced in macrophages after LPS stimulation. The decrease in SIRPα expression levels was required for initiation of LPS-induced innate immune responses because overexpression of SIRPα reduced macrophage responses to LPS. Knockdown of SIRPα caused prolonged activation of MAPKs and NF-κB pathways and augmented production of proinflammatory cytokines and type I interferon (IFN). Mice transferred with SIRPα-depleted macrophages were highly susceptible to endotoxic shock, developing multiple organ failure and exhibiting a remarkable increase in mortality. SIRPα may accomplish this mainly through its association and sequestration of the LPS signal transducer SHP-2. Thus, SIRPα functions as a biologically important modulator of TLR signaling and innate immunity.
FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI. THE DEVELOPMENT OF RESISTANCE TO FIBRINOLYSIS FOLLOWING ACUTE HEMOLYTIC STREPTOCOCCUS INFECTIONS
Authors: William S. Tillett, L. B. Edwards, R. L. Garner
Journal: Journal of Clinical Investigation (1934)

In several instances, the hemolytic streptococci isolated from a patient, were used in tests with the patients' plasma.In such observations, however, no specificity was demonstrable, and no special advantage was obtained by employing strains and plasma from the same patient.Although sterile filtrates have been found to contain the fibrinolytic principle in large quantities, whole broth cultures were employed in all the tests reported in this communication.Since the tests were designed to determine resistance to clot liquefaction, the more potent cultures have been used instead of filtrate, in order to make the test more stringent and exacting.Anticoagulant.Potassium oxalate has been regularly employed in amounts of 0.02 gram of oxalate to 10 cc. of blood.A 2 per cent solution is made in distilled water.One cubic centimeter of this solution is placed in small bottles which are heated in a dry air sterilizer until all water has evaporated.Ten cubic centimeters of blood, immediately after withdrawal, are mixed with the dried powder.
A COMPARISON OF THE EFFECTS OF PYRIDOXINE AND PANTOTHENIC ACID DEFICIENCIES ON THE NERVOUS TISSUES OF SWINE
Authors: Richard H. Follis, Maxwell M. Wintrobe
Journal: The Journal of Experimental Medicine (1945)

1. When pigs were fed diets deficient in pyridoxine or pantothenic acid, ataxia developed and lesions were found in the sensory neuron. 2. The morphological pattern of the lesions differed in the early stages of the two deficient states. Degeneration of the peripheral process of the sensory neuron was the initial and most prominent feature in pyridoxine deficiency. Chromatolysis was the first evidence of damage to the afferent neuron in pantothenic acid-deficient animals. 3. The possible significance of this evidence of damage to different portions of the sensory neuron is discussed.
Re: Prognostic Significance of a Short Sequence Insertion in the MCL-1 Promoter in Chronic Lymphocytic Leukemia
Authors: Scott N. Freeman, Gerold Bepler, Eric Haura, Rebecca Sutphen, W. Douglas Cress
Journal: JNCI Journal of the National Cancer Institute (2005)

Wt = wild-type allele; 6 = 6-nucleotide insertion; 18 = 18-nucleotide insertion.† B-CLL = B-cell chronic lymphocytic leukemia
Introducing JAMA Clinical Guidelines Synopsis
Authors: Adam S. Cifu, Andrew M. Davis, Edward H. Livingston
Journal: JAMA (2014)

Physicians are busy and often do not have the time to review a single topic in enough depth to successfully aggregate and synthesize current research into a single coherent theme that can guide practice, and they maynothave theexpertise to critically appraise complex primary research studies and apply the results todeterminehowbest todelivermedical care. Thepurposeof clinical guidelines is to accomplish these tasks for physicians. However, committees that prepare guidelines often fail toproduceadocument thatmostphysicians canuse. Guideline documents are often hundreds of pages long,making themdifficult and time-consuming to readanddigest. The deployment of guidelines through electronic medical record decision support tools or applications on handheld electronicdevices canbehelpful, but these tools cannotassistwith the nuanced decision making required for providing care to individual patients. Another problem with clinical guidelines is that they are not all equal. On the one hand, some guidelines are produced by committees that are unbiased butmay lack the content expertise for the clinical problem being assessed. On the other hand, someguidelinesareproducedbyhighlyspecializedcommittees thathave content expertise but aremore likely tohave conflictsof interest thatmay lead tobiasedoutcomes. Ineither situation, the resultingguidelinesdonotgeneralizewell toprimary care populations and the unique circumstances of individual patients.1 To help address these issues, in this issue of JAMA, we are launching a new series: JAMA Clinical Guidelines Synopsis.2 These brief articles concisely summarize guideline recommendations in a format designed for busy physicians. Each article will have an overview of the major recommendations from the guideline, will identify the groups that issued and funded the guideline, and will link to selected associated guidelines and resources. Each article will summarize the clinical problem, review the evidence base for the guideline, note the potential benefits or harms related to instituting the guideline’s recommendations, and suggest future areas of research. A major feature of JAMA Clinical Guidelines Synopsis articles will be a table that rates the guideline being Related article page 1248
Regulation of active sodium and potassium transport in the distal colon of the rat. Role of the aldosterone and glucocorticoid receptors.
Authors: S G Turnamian, H J Binder
Journal: Journal of Clinical Investigation (1989)

To determine whether mineralocorticosteroids and glucocorticosteroids have specific effects on colonic electrolyte transport, we compared the effect of aldosterone and RU 28362, a glucocorticoid receptor-specific agonist that does not bind to the aldosterone receptor, on unidirectional Na, Cl, and K fluxes across isolated mucosa of the rat distal colon. Continuous infusion of aldosterone for 7 d produced changes in four specific transport processes: induction of both active electrogenic, amiloride-sensitive sodium absorption and active electrogenic potassium secretion, enhancement of active electroneutral potassium absorption, and inhibition of electroneutral Na-Cl absorption, the predominant transport process in this epithelium. In contrast, continuous infusion of RU 28362 for 1-11 d produced a sustained increase in electroneutral Na-Cl absorption. This glucocorticoid receptor-specific agonist did not induce electrogenic sodium absorption nor affect either potassium absorption or secretion. These studies demonstrate that aldosterone (i.e., mineralocorticoid) and glucocorticoid receptors modulate separate and specific changes in active sodium and potassium transport. These results suggest that other glucocorticoids (e.g., dexamethasone, methylprednisolone) are not glucocorticoid receptor-specific and that their effects on electrogenic sodium absorption and potassium transport most likely represent the binding of these agonists to the aldosterone receptor.
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
Authors: Markus Guba, Philipp von Breitenbuch, Markus Steinbauer, Gudrun Koehl, Stefanie Flegel, Matthias Hornung, Christiane J. Bruns, Carl Zuelke, Stefan Farkas, Matthias Anthuber, Karl-Walter Jauch, Edward K. Geissler
Journal: Nature Medicine (2002)
Gene Density and Human Nucleotide Polymorphism
Authors: Bret A. Payseur, Michael W. Nachman
Journal: Molecular Biology and Evolution (2002)

Population genetics theory indicates that natural selection will affect levels and patterns of genetic variation at closely linked loci. Background selection (Charlesworth, Morgan, and Charlesworth 1993) proposes that the removal of recurrent deleterious mutations and associated neutral variants will cause a reduction of nucleotide variation in low-recombination regions. The strength of background selection depends on the deleterious mutation rate, the magnitude of selection and dominance, and the recombination rate. Genetic hitchhiking (Maynard Smith and Haigh 1974), the fixation of advantageous alleles and the associated fixation of linked neutral alleles, can also decrease nucleotide diversity in low-recombination regions. The extent of genetic hitchhiking depends on the strength of selection and the rate of recombination. Therefore, under both background selection and genetic hitchhiking, theory predicts that genomic regions that rarely recombine may be subject to reductions in nucleotide diversity. Furthermore, if the rate of deleterious mutation or selective sweeps (or both) is sufficiently high, background selection (Hudson and Kaplan 1995) and genetic hitchhiking (Wiehe and Stephan 1993) models predict an overall positive correlation between nucleotide polymorphism and recombination rate. Empirical investigations of nucleotide variation support these predictions. In Drosophila melanogaster, regions of the genome with little recombination show reduced heterozygosity (Aguade, Miyashita, and Langley 1989; Begun and Aquadro 1991; Berry, Ajioka, and Kreitman 1991). Furthermore, there is evidence that nucleotide variation and recombination rate are positively correlated in several taxa, including fruit flies (Begun and Aquadro 1992), house mice (Nachman 1997), goatgrasses (Dvorak, Luo, and Yang 1998), sea beets (Kraft et al. 1998), tomatoes (Stephan and Langley 1998), humans (Nachman et al. 1998; Przeworski, Hudson, and Di Rienzo 2000; Nachman 2001), and maize (Tenaillon et al. 2001). The combination of theoretical and empirical results indicates that selection acting at linked sites is likely to be a major force shaping genomic patterns of nucleotide variation. The documented relationship between nucleotide variation and recombination rate raises the question of whether other measurable variables can explain additional variation in nucleotide polymorphism in the context of selection at linked sites. We predict that the effects of selection at linked sites will depend on local
Impaired myocardial development resulting in neonatal cardiac hypoplasia alters postnatal growth and stress response in the heart
Authors: Jörg-Detlef Drenckhahn, Jette Strasen, Kirsten Heinecke, Patrick Langner, Kom Voy Yin, Friederike Skole, Maria Hennig, Bastian Spallek, Robert Fischer, Florian Blaschke, Arnd Heuser, Timothy C. Cox, Mary Jane Black, Ludwig Thierfelder
Journal: Cardiovascular Research (2015)

Foetal growth has been proposed to influence cardiovascular health in adulthood, a process referred to as foetal programming. Indeed, intrauterine growth restriction in animal models alters heart size and cardiomyocyte number in the perinatal period, yet the consequences for the adult or challenged heart are largely unknown. The aim of this study was to elucidate postnatal myocardial growth pattern, left ventricular function, and stress response in the adult heart after neonatal cardiac hypoplasia in mice. Utilizing a new mouse model of impaired cardiac development leading to fully functional but hypoplastic hearts at birth, we show that myocardial mass is normalized until early adulthood by accelerated physiological cardiomyocyte hypertrophy. Compensatory hypertrophy, however, cannot be maintained upon ageing, resulting in reduced organ size without maladaptive myocardial remodelling. Angiotensin II stress revealed aberrant cardiomyocyte growth kinetics in adult hearts after neonatal hypoplasia compared with normally developed controls, characterized by reversible overshooting hypertrophy. This exaggerated growth mainly depends on STAT3, whose inhibition during angiotensin II treatment reduces left ventricular mass in both groups but causes contractile dysfunction in developmentally impaired hearts only. Whereas JAK/STAT3 inhibition reduces cardiomyocyte cross-sectional area in the latter, it prevents fibrosis in control hearts, indicating fundamentally different mechanisms of action. Impaired prenatal development leading to neonatal cardiac hypoplasia alters postnatal cardiac growth and stress response in vivo, thereby linking foetal programming to organ size control in the heart.
COMPARISON OF UNRESTRICTED USE OF RESOLUTE ZOTAROLIMUS-ELUTING AND EVEROLIMUS-ELUTING STENTS: OUTCOMES IN A REAL WORLD SETTING OF CORONARY INTERVENTION IN KOREANS
Authors: Joo Myung Lee, Tae-Jin Youn, Il-Young Oh, Jung-Won Suh, Chang-Hwan Yoon, Young-Seok Cho, Goo-Yeong Cho, Dong-Ju Choi, In-Ho Chae
Journal: Journal of the American College of Cardiology (2012)
VOLVULUS OF THE OMENTUM.
Authors: FRANCIS T. STEWART
Journal: JAMA (1904)

Including my case nine instances of volvulus of the omentum have been recorded in surgical literature. These are as follows: <h3>Case 1.</h3> —Male, aged 35 years, a patient of Dr. Alfred Allman, for whom I operated. His mother, a sister and six children are living and in good health. He had never suffered from any serious illness. Four days before operation, while in the best of health, he was attacked by severe abdominal pains, which began in the epigastrium, and which later settled in the right iliac region. He vomited at this time and went to bed. The pain grew worse and the vomiting persisted. I saw the patient for the first time June 19, 1902, on the fourth day of the illness. He was a large, well-nourished man, sweating freely, and evidently suffering severe pain. His temperature was 101 F., the pulse 120, and the respirations 20.
The 10-year incidence of renal insufficiency in people with type 1 diabetes.
Authors: R Klein, B E Klein, S E Moss, K J Cruickshanks, P C Brazy
Journal: Diabetes Care (1999)

OBJECTIVE: To describe the 10-year decrease in estimated creatinine clearance and the incidence of renal insufficiency and end-stage renal disease in a cohort of people with type 1 diabetes. RESEARCH DESIGN AND METHODS: A population-based cohort of individuals with younger-onset diabetes (diagnosed at &amp;lt; 30 years old and taking insulin) participated in an examination during 1984-1986 (n = 891), a 6-year follow-up examination during 1990-1992 (n = 765), and a 10-year follow-up examination during 1995-1996 (n = 634). Serum creatinine and risk factors were measured during standardized protocols at each examination. Estimated adjusted creatinine clearance was computed by a modification of the Cockroft-Gault formula. A clinically meaningful change was defined as a decrease in the estimated annual creatinine clearance of &amp;gt; or = 3 ml.min-1.1.73 m-2.year-1. Renal insufficiency was defined by the development of a serum creatinine of 2.0 mg/dl or greater after the 1984-1986 examination. RESULTS: The 10-year estimated incidence of an annual decrease in the creatinine clearance of &amp;gt; or = 3 ml.min-1.1.73 m-2 for the cohort was 52.5%, and the cumulative 10-year incidence of renal insufficiency and end-stage renal failure was 14.4%. In univariate analyses, incidence of a decrease in the estimated creatinine clearance of &amp;gt; or = 3 ml.min-1.1.73 m-2.year-1 and the incidence of renal insufficiency were both related to higher glycosylated hemoglobin; higher diastolic blood pressure; the presence of microalbuminuria and gross proteinuria; more severe retinopathy; and a history of loss of tactile sensation or temperature sensitivity at baseline. In logistic regression analysis, after adjusting for the presence of microalbuminuria and gross proteinuria at baseline, higher glycosylated hemoglobin and higher diastolic blood pressure were associated with decreasing estimated creatinine clearance. In logistic regression analyses, after adjusting for the presence of microalbuminuria and gross proteinuria at baseline, the incidence of renal insufficiency was independently associated with age, glycosylated hemoglobin, hypertension, and serum HDL cholesterol. CONCLUSIONS: These data suggest that a public health approach aimed at controlling glycemia, blood pressure, and serum lipids might result in reducing the rate of decline in renal function and development of renal insufficiency in people with type 1 diabetes.
Regional Variations in Plasma Fibrinogen Levels
Authors: E. Ernst
Journal: Annals of Internal Medicine (1991)

Letters15 August 1991Regional Variations in Plasma Fibrinogen LevelsE. Ernst, MDE. Ernst, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-4-329_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Fibrinogen is currently recognized as a major, independent risk factor for cardiovascular disease. Several population-based studies have linked fibrinogen with other risk factors and with incidence of future cardiovascular events (1). These studies have also produced a rich source for "normal" values that, surprisingly, range from 2.3 to 4.0 g/L. Obviously, the method of measurement has a strong influence. I therefore looked only at those studies that employed the standard method based on thrombin coagulation time; at least three other methods are frequently used (Table 1).Mean fibrinogen values vary from 2.3 to 3.1 g/L. This cannot...References1. Ernst E. Fibrinogen, an independent cardiovascular risk factor. J Int Med. 1990;227:365-72. CrossrefMedlineGoogle Scholar2. Lee A, Smith W, Lowe G, and Tunstall-Pedoe H. Plasma fibrinogen and coronary risk factors. J Clin Epidemiol. 1990;43:913-9. CrossrefMedlineGoogle Scholar3. Balleisen L, Bailey J, Epping P, Schulte H, and van de Loo J. Epidemiological study on factor VII, factor VIII and fibrinogen in an industrial population. Thromb Haemost. 1985;54:475-9. CrossrefMedlineGoogle Scholar4. Baker J, Eastham R, Elwood P, Etherington M, O'Brien J, and Sweetnam P. Haemostatic factors associated with ischaemic heart disease in men aged 45 to 64 years. Br Heart J. 1982;47:490-4. CrossrefMedlineGoogle Scholar5. Rosengren A, Wilhelmsen L, Welin L, Tsipogianni A, Teger-Nilson A, and Wedel H. Social influences and cardiovascular risk factors as determinants of plasma fibrinogen concentration in a general population sample of middle aged men. Br Med J. 1990;300:634-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: E. Ernst, MDAffiliations: University of Vienna A-1097 Vienna Austria PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHelicobacter pylori infection is not a correlate of plasma fibrinogen in the Australian populationFibrinogen and agingFibrinogen: The plot thickensRegional Variations in Plasma FibrinogenDonald E. McMillan, MD, John I. Malone, MD 15 August 1991Volume 115, Issue 4 Page: 329-330 Keywords Blood plasma Cardiovascular disease risk Cardiovascular diseases Fibrinogen Forecasting Medical risk factors Thrombin ePublished: 1 December 2008 Issue Published: 15 August 1991 PDF downloadLoading ...
De Subitaneis Mortibus
Authors: THOMAS N. JAMES, RICHARD S. ARMSTRONG, JAY SILVERMAN, THOMAS K. MARSHALL
Journal: Circulation (1974)

Special studies of the heart were conducted at necropsy of two young soldiers who had died suddenly and unexpectedly. In the first case there was extensive myocarditis, an atretic main left coronary artery, special large interarterial anastomoses including the sinus node artery, old fibrosis in the His bundle and recent hemorrhages in the internodal pathways. In the second case there was a markedly narrowed atrioventricular (A-V) node artery with disruptive fibrosis of the left and right bundle branches, and lacunar faults in the central fibrous body near the A-V node. These dissimilar findings are discussed relative to the pathophysiological basis of sudden death.
The Virus of Hepatitis, Type B
Authors: William S. Robinson, Larry I. Lutwick
Journal: New England Journal of Medicine (1976)

The discovery of hepatitis B antigen1 2 3 4 has led to studies of the physical and chemical nature of the antigen and to the discovery of different structural forms of the antigen, some of which have properties of an incomplete virus and at least one having properties consistent with those of a complete virus. Here, we review some of the more recently acquired knowledge of the morphologic, antigenic and macromolecular structure of the hepatitis B antigen forms and compare hepatitis B virus (HBV) with better studied viruses. Some of the clinical and biologic implications of the recent findings . . .
STERILE LANCETS FOR BLOOD SAMPLING
Authors: Carl W. Walter
Journal: JAMA (1952)

Among the epidemiological factors in the transmission of homologous serum jaundice, the spread via cannulated needles used for obtaining blood samples and tattooing needles has been substantiated. 1 The possibility of needle transmission of poliomyelitis has been emphasized. 2 Sterilization in saturated steam at 121 C or dry heat at 160 C is essential, because chemical disinfection is inadequate against the virus concerned.  Safe acupuncture of the individual patient presents problems in packaging, sterilizing, and dispensing lancets. Accidental pricking of the fingers of technicians and supply room workers must be guarded against. In hospital and clinic practice and blood donor evaluation, so many lancets are used that maintenance of sharpness, the provision for automatic cleaning, and prevention of loss are major considerations. A technique is presented that accomplishes these ends.  The lancets (fig. 1) are made of a piece of cutlery stainless steel embedded in a waterproof nylon handle. The
Human Eosinophils Enhance Staphylococcal Enterotoxin B Stimulation of CD4+ T-cells
Authors: S.K. Mathur, E.A. Durocher, L. Liu, E.A.B. Kelly, J.B. Sedgwick, N.N. Jarjour, W.W. Busse
Journal: Journal of Allergy and Clinical Immunology (2006)