tbuckley/cabot-search huggingface dataset:
Mevalonate Kinase Deficiency and Autoinflammation
Authors: Elizabeth J. Hager, K. Michael Gibson
Journal: New England Journal of Medicine (2007)

To the Editor: The Perspective article about mevalonate kinase deficiency and autoinflammatory disorders by Haas and Hoffmann (June 28 issue)1 accompanies the Brief Report by Neven et al.2 The Perspective describes the disease spectrum of human mevalonate kinase deficiency, which includes unexplained periodic episodes of fever and inflammation, and discusses treatment regimens used to alleviate symptoms in patients with the disease. In this context, we believe it is necessary to clarify statements in the Perspective that imply that a causal effect of the inflammation in patients with mevalonate kinase deficiency may relate to a type 2 helper T cell bias . . .
Impact of type 1 and type 2 diabetes on patterns and costs of drug prescribing: a population-based study.
Authors: J M Evans, T M MacDonald, G P Leese, D A Ruta, A D Morris
Journal: Diabetes Care (2000)

OBJECTIVE: Utilization and costs of prescription drugs were investigated in diabetic and nondiabetic patients. RESEARCH DESIGN AND METHODS: The study was carried out in Tayside, Scotland, U.K. A validated population-based diabetes register was used to identify patients with type 1 and type 2 diabetes, and a database of all prescriptions dispensed in the community was used to investigate drug utilization in 1995. RESULTS: In a population of 406,526, there were 974 (0.2%) with type 1 diabetes and 6,869 (1.7%) with type 2 diabetes. The mean dispensed prescribing rates for all drugs (excluding antidiabetic medication) were higher across all age-groups for diabetic patients. After adjusting for age, patients with type 1 diabetes were 2.07 times (95% CI 2.03-2.11) more likely and patients with type 2 diabetes were 1.70 times (1.69-1.71) more likely to be dispensed a drug item than people without diabetes. This likelihood was increased in every drug category, even those not directly related to diabetes, and the proportion and cost of drug items dispensed to diabetic patients was therefore higher than expected given the prevalence of diabetes. Upon projecting these results to the U.K. population, it was discovered that nearly 8% of the U.K. drug budget (Pound Sterling 350 million) is accounted for by patients with diabetes (90% of that by patients with type 2 diabetes). CONCLUSIONS: This study highlights the increased usage and cost of prescription drugs in diabetes, with type 2 diabetes constituting a particular burden. It was discovered that 1.4% of drug usage in the entire population can be accounted for by the increased prescribing rate of diabetic patients compared with that of nondiabetic patients.
Low-Fluence Photodynamic Therapy versus Ranibizumab for Chronic Central Serous Chorioretinopathy
Authors: So Hyun Bae, Jangwon Heo, Cinoo Kim, Tae Wan Kim, Joo Young Shin, Joo Yong Lee, Su Jeong Song, Tae Kwann Park, Sang Woong Moon, Hum Chung
Journal: Ophthalmology (2013)
JAMA and AIDS: Too Much? Not Enough?
Authors: Allan R. Tunkel
Journal: JAMA (1989)

To the Editor. —  In the Letter to the Editor that appeared in the January 27 issue of JAMA , Dr Kubin 1 asks that JAMA restrict the publication of articles about the acquired immunodeficiency syndrome (AIDS). I disagree with many of his statements. First, he maintains that practicing physicians are inundated with information about AIDS and that almost every issue of JAMA has an article about AIDS. It may seem that way to Dr Kubin, but the overall percentage of articles and letters concerning AIDS is not that great. To illustrate this point, I reviewed the table of contents of all issues of JAMA during the calendar year 1988, including all articles about AIDS, AIDS-related complex, or AIDS risk factors. As can be seen in the Table, only 13.1% of all articles published in JAMA over that period concerned AIDS. On further breakdown by journal section, the work of researchers
Adverse drug reactions as cause of admission to hospital: Authors' reply
Authors: Munir Pirmohamed, Sally James, Shaun Meakin, Chris Green
Journal: BMJ (2004)

EDITOR—The aim of our study was to elucidate the prevalence of adverse drug reactions associated with prescribed medicines. We agree with Williams and Taylor that alcohol and herbal medicines may be contributory factors but thought that our study could not accurately report on this aspect because of difficulties in verification of intake. More studies of a different design are needed in this area, and we are currently addressing the role of alcohol in warfarin related adverse drug reactions in a prospective study of 2000 patients using the AUDIT questionnaire,1 a validated instrument to assess alcohol misuse.

With regard …
Low-dose cyclosporin A in severe psoriasis. A double-blind study
Authors: TH. JOOST, J.D. BOS, F. HEULE, M.M.H.M. MEINARDI
Journal: British Journal of Dermatology (1988)

Twenty patients with severe plaque psoriasis were selected to receive either low‐dose cyclosporin A (CyA) or placebo (CyA vehicle) in a double‐blind randomized trial at two centres. Within 4 weeks the mean reduction in the Psoriasis Area and Severity Index (PASI) in 10 patients receiving CyA (mean dose 5.5 mg/kg/day) differed significantly from the mean reduction in 10 patients receiving placebo. In eight patients given placebo a switch to CyA therapy resulted within 4 weeks in a mean reduction in PASI of 90%. In a total 15 out of 18 patients given CyA (83%) (mean dose 5.6 mg/kg/day) there was an improvement of ≥ 75% in PASI within 4 weeks. In a 2‐month tapering off phase a lower mean CyA dose (3 mg/kg/day) was effective in maintaining the reduced PASI scores in seven of nine patients. Four out of five CyA treated patients who entered a post‐treatment observation phase had a relapse (PASI score ≥ 50% of score at baseline) after a mean interval of 6.5 weeks. The most important side‐effects were mild reversible hypertension in 5 of 18 patients (28%), and reversible elevated serum creatinine levels in 7 of 18 patients (39%). We consider that further studies are justified in severe chronic psoriasis to establish suitable regimens for maintenance of remission in psoriasis with low‐doses of CyA or a combination of CyA with other anti‐psoriatic agents.
Sex differences may indeed exist for 3-D navigational abilities: But was sexual selection responsible?
Authors: Peter Frost
Journal: Behavioral and Brain Sciences (1998)

Polygyny does not necessarily entail sexual selection of men. All factors that affect the operational sex ratio must be considered. Data from contemporary hunter-gatherers indicate higher mortality rates in men than in women, and lost female reproductive time. If sexual selection did occur in ancestral hunter-gatherers, it was probably men selecting women and not women selecting men.
miR-186 Downregulation Correlates with Poor Survival in Lung Adenocarcinoma, Where It Interferes with Cell-Cycle Regulation
Authors: Junchao Cai, Jueheng Wu, Huizhong Zhang, Lishan Fang, Yongbo Huang, Yi Yang, Xun Zhu, Rong Li, Mengfeng Li
Journal: Cancer Research (2012)

Abstract Deeper mechanistic understanding of lung adenocarcinoma (non–small cell lung carcinoma, or NSCLC), a leading cause of cancer-related deaths overall, may lead to more effective therapeutic strategies. In analyzing NSCLC clinical specimens and cell lines, we discovered a uniform decrease in miR-186 (MIR186) expression in comparison with normal lung tissue or epithelial cell lines. miR-186 expression correlated with patient survival, with median overall survival time of 63.0 or 21.5 months in cases exhibiting high or low levels of miR-186, respectively. Enforced overexpression of miR-186 in NSCLC cells inhibited proliferation by inducing G1–S checkpoint arrest. Conversely, RNA interference–mediated silencing miR-186 expression promoted cell-cycle progression and accelerated the proliferation of NSCLC cells. Cyclin D1 (CCND1), cyclin-dependent kinase (CDK)2, and CDK6 were each directly targeted for inhibition by miR-186 and restoring their expression reversed miR-186–mediated inhibition of cell-cycle progression. The inverse relationship between expression of miR-186 and its targets was confirmed in NSCLC tumor xenografts and clinical specimens. Taken together, our findings established a tumor-suppressive role for miR-186 in the progression of NSCLC. Cancer Res; 73(2); 756–66. ©2012 AACR.
Correlates of the “Don't Know” Response to Questions about Snoring
Authors: DONALD L. BLIWISE, GARY E. SWAN, DORIT CARMELLI, ASENATH LA RUE
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Many persons say that they “don't know” whether they snore. The purpose of this study was to investigate the prevalence and correlates of such responses in an elderly population. Subjects were 1715 members (1,155 men, 560 women) of a previously defined cohort (Western Group Collaborative Study) followed prospectively since 1960–1961 with a current mean age of 75.9 (SD = 4.3) for the men and 71.4 (SD = 5.3) for the women. We collected survey questionnaires and reviewed medical records. Results indicated that risk factors for the “don't know” response in this population were similar to those for frequent snoring and included: male sex, higher Body Mass Index, smoking, and use of sinus medication. Between 28 and 44% of the cohort answered questions about snoring with a “don't know” response. These data are compatible with the interpretation that subjects may disavow knowledge of their own snoring and suggest that future studies consider the “don't know” response to questions about snoring as a response of potential interest. Bliwise DL, Swan GE, Carmelli D, La Rue A. Correlates of the “don't know” response to questions about snoring.
Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium.
Authors: J G De Mey, P M Vanhoutte
Journal: Circulation Research (1982)

Experiments were designed to determine the contribution of endothelial cells to the heterogeneous behavior of the arterial and venous wall. Rings of canine femoral, pulmonary, saphenous, and splenic arteries and veins, with and without endothelium, were mounted for isometric tension recording in Krebs-Ringer bicarbonate solution. Endothelium-dependent inhibitory responses to acetylcholine, adenosine triphosphate, bovine thrombin, and arachidonic acid were prominent in the arteries. In the veins, only transient endothelium-dependent relaxations to these substances were observed. Removal of the endothelium decreased the augmentation of the response to norepinephrine caused by anoxia in both arteries and veins. In the veins, arachidonic acid and thrombin caused endothelium-dependent increases in tension during contractions evoked by norepinephrine. The endothelium-independent inhibitory effects of isoproterenol and adenosine and the excitatory effects of acetylcholine and ATP were more pronounced in the veins than in the arteries. These experiments demonstrate that in the arterial and venous wall the endothelial cells can contribute to both inhibitory and excitatory responses of the smooth muscle cells of the media. Inhibitory endothelial responses prevail in the arteries, and excitatory ones in the veins.
Follow-up of Patients with Early Breast Cancer
Authors: Daniel F. Hayes
Journal: New England Journal of Medicine (2007)

An otherwise healthy 53-year-old woman is seen for routine care after completing treatment several months earlier for stage II estrogen-receptor–positive, HER2-positive breast cancer. The treatment consisted of lumpectomy, irradiation, adjuvant chemotherapy (doxorubicin and cyclophosphamide followed by paclitaxel), and trastuzumab. Her only current medication is an aromatase inhibitor. She is amenorrheic. She reports fatigue, hot flashes, arthralgias, and sexual difficulties and is concerned about the risk of a recurrence. How would you follow this patient, and what would you recommend for her symptoms?
Abstract 5534: Evaluation of clinical safety and immunogenicity of DPX-0907, a multi-epitope vaccine for the treatment of breast, ovarian and prostate cancers
Authors: Rita Nigam, Mohan Karkada, Genevieve M. Weir, Lisa D. MacDonald, Neil Berinstein, Marc Mansour
Journal: Cancer Research (2011)

Abstract A successful cancer vaccine needs to overcome tumor-induced immune suppression while enhancing protective Type1-biased tumor-specific immune responses. To achieve this, enhanced vaccine delivery technologies are needed. We have developed a novel liposome-in-oil depot vaccine platform called DepoVaxTM (DPX) which increases the potency of peptide-based cancer vaccines and elicits a strong cytotoxic T cell response. DPX-0907 is a human DPX-based vaccine containing 7 HLA-A2 restricted peptides and is indicated for breast, ovarian and prostate cancer. The antigens were carefully selected with a multi-targeted approach that focuses on proteins involved in pathways that are critical for the survival of a cancer cell. This reduces the likelihood of immune escape through loss of antigen expression/presentation as a tumor responds to vaccine-induced immune pressure. We recently showed that DPX-0907 produces stronger and better sustained immune responses in HLA-A2 transgenic mice than a GM-CSF/ emulsion vaccine. A multicenter phase I clinical trial was initiated in five US clinical sites in March 2010 to evaluate the safety and immunogenicity of DPX-0907 in patients with advanced breast, ovarian or prostate cancer. The open label, dose escalation study recruited patients into one of 2 dose levels (0.25 mL and 1 mL). The vaccine was administered subcutaneously every three weeks for a total of three vaccinations. PBMC's were collected prior to each vaccination and at three time points following the last vaccination. These samples were also used to monitor the immunosuppressive MDSC population in patients receiving the vaccine treatment. In addition, immune monitoring of vaccine-induced responses is based on multi-parametric intracellular cytokine staining of multiple immune cell types and the functional analysis of peptide-MHC-multimer positive CD8 T cells. This first- in-man trial has generated important safety information that support the use of DepoVax for delivering multi-peptide based vaccines. The extensive immune monitoring will aid in the rational design of future DPX-0907 and other DepoVax-based vaccine trials. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5534. doi:10.1158/1538-7445.AM2011-5534
The 11th Revision of the<i>International Classification of Diseases</i>(<i>ICD</i>)
Authors: Raad Shakir, Sanjeev Rajakulendran
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Multiple Endocrine and Metabolic Disease Syndrome
Authors: Murray L. Fields, Luther L. Burkett
Journal: JAMA (1964)

IT IS BECOMING more and more apparent that some patients and families are prone to develop multiple, but varying combinations of, endocrine diseases. This report concerns a patient who has had Graves' disease, carcinoma of the thyroid, hyperparathyroidism due to a parathyroid adenoma, and gout. Although the association of these four diseases is unique, so far as we know, we feel that their appearance together is more than coincidental. Evidence is presented to indicate that the endocrine adenomatosis syndrome should be enlarged to include endocrine gland carcinoma, endocrine gland hyperplasia, and possibly one metabolic disease not due to an endocrine abnormality. The present case is an example of this syndrome. <h3>Report of a Case</h3> A 48-year-old white male enjoyed good health until the age of 23 when he developed symptoms of hyperthyroidism and was found to have a thyroid nodule. He was thought to have a hyperfunctioning thyroid adenoma and
Relation Between Renal Interstitial ATP Concentrations and Autoregulation-Mediated Changes in Renal Vascular Resistance
Authors: Akira Nishiyama, Dewan S. A. Majid, Khandaker A. Taher, Akira Miyatake, L. Gabriel Navar
Journal: Circulation Research (2000)

Abstract —The present study was performed to examine the hypothesis that autoregulation-related changes in renal vascular resistance (RVR) are mediated by extracellular ATP. By use of a microdialysis method, renal interstitial concentrations of ATP and adenosine were measured at different renal arterial pressures (RAPs) within the autoregulatory range in anesthetized dogs (n=12). RAP was reduced in steps from the ambient pressure (131±4 mm Hg) to 105±3 mm Hg (step 1) and 80±2 mm Hg (step 2). Renal blood flow and glomerular filtration rate exhibited efficient autoregulation in response to these changes in RAP. RVR decreased by 22±2% in step 1 ( P &lt;0.01) and 38±3% in step 2 ( P &lt;0.01). The control renal interstitial concentration of ATP was 6.51±0.71 nmol/L and decreased to 4.51±0.55 nmol/L in step 1 ( P &lt;0.01) and 2.77±0.47 nmol/L in step 2 ( P &lt;0.01). In contrast, the adenosine concentrations (117±6 nmol/L) were not altered significantly. Changes in ATP levels were highly correlated with changes in RVR ( r =0.88, P &lt;0.0001). Further studies demonstrated that stimulation of the tubuloglomerular feedback (TGF) mechanism by increasing distal volume delivery elicited with acetazolamide also led to increases in renal interstitial ATP concentrations, whereas furosemide, which is known to block TGF responses, reduced renal interstitial fluid ATP concentrations. The data demonstrate a positive relation between renal interstitial fluid ATP concentrations and both autoregulation- and TGF-dependent changes in RVR and thus support the hypothesis that changes in extracellular ATP contribute to the RVR adjustments responsible for the mechanism of renal autoregulation.
A milestone for myocardial infarction.
Authors: S. A. Livesey, M. Douzinas, S. C. Lennox
Journal: BMJ (1988)

difference of 2 0 cm between social classes I and V.The age standardised difference between manual and non-manual groups was 0 9 cm.Differences between manual and non-manual groups showed a tendency to increase .4ithage, from 0-64 cm in 5 year olds to 1-96 cm in 7 year olds, although the effect did not reach conventional levels of statisti- cal significance (p=0 09).An analysis of height differences in the national child development study cohort (born in 1958) at age 7 showed a mean difference of 3 3 cm between social classes I and II and social class V.3 A study of 5-11 year-olds born in 1960-7 suggested a median difference of 2 cm between manual and nonmanual groups.4Although the differences appear smaller in our study, comparisons require cautious interpretation because of differences in population selection and because of the suggestion in our data that social class differences in height increase with age.What the results show clearly is that important inequalities in height are still present in the first decade of life in Great Britain.
IMPLICATIONS OF BUNDLE BRANCH BLOCK IN PATIENTS UNDERGOING PRIMARY ANGIOPLASTY IN THE STENT ERA: SHORT AND LONG-TERM PROGNOSIS
Authors: David Vivas, Maria Jose Pérez-Vizcayno, Antonio Fernández-Ortiz, Camino Bañuelos, Javier Escaned, Pilar Jiménez-Quevedo, Ivan Núñez-Gil, Juan Jose González-Ferrer, Rosana Hernández-Antolin, Carlos Macaya, Fernando Alfonso
Journal: Journal of the American College of Cardiology (2010)
Remission of Felty's Syndrome With Long-Term Testosterone Therapy
Authors: Bruce M. Wimer
Journal: JAMA (1973)

Three men with Felty's syndrome were treated with long-term testosterone therapy. Two had a full, and one a partial, correction of the neutropenia and a concomitant abatement of tendency to infection. For the two patients with complete correction of the neutropenia, full recovery of neutrophils took 20 and 24 months, respectively, correlating with diminution in splenomegaly. Testosterone may increase stem cell commitment to granulopoiesis, at the same time diminishing lymphopoiesis. It may also exert a weak lympholytic effect.
ABSTRACT—A LARYNGEAL NEOPLASM SIMULATING THE EVERTED VENTRICLE.Read in the Section on Laryngology and Otology, at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: S. K. MERRICK
Journal: JAMA (1894)

able apprehension for inflammatory complications of the middle ear, so that I rarely allow a patient to go
Building a Better X-ray
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Watchdog advises patients to fight for their rights
Authors: J. Wise
Journal: BMJ (2013)

The public should become “savvy consumers” rather than “grateful patients,” says Healthwatch England in its first report to parliament.

Healthwatch England was set up in April this year as part of the shake-up of the NHS introduced by the Health and Social Care Act. The national body heads up a network of 152 local patient bodies, with the aim of championing the needs of …