Piroxicam-Induced Renal Failure and Hyperkalemia
Authors: MICHAEL A. FRAIS
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 July 1983Piroxicam-Induced Renal Failure and HyperkalemiaMICHAEL A. FRAIS, M.D., ELLEN D. BURGESS, M.D., L. BRENT MITCHELL, M.D.MICHAEL A. FRAIS, M.D.Search for more papers by this author, ELLEN D. BURGESS, M.D.Search for more papers by this author, L. BRENT MITCHELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-1-129_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We report a case of piroxicam-induced acute renal failure and hyperkalemia. Although these complications have accompanied the use of other nonsteroidal antiinflammatory agents (1-4), they have not to our knowledge been reported with piroxicam.An 82-year-old white woman had a long history of hypertension, cerebrovascular disease, stable angina pectoris, and rheumatoid arthritis. She was taking prednisone, folic acid, timolol, triamterene-hydrochlorothiazide, and digoxin, and developed bilateral lumbar pain. The patient was treated with oral cotrimoxazole and piroxicam. Six days later, effort-induced dyspnea and frequent presyncopal episodes necessitated hospital admission.The patient's heart rate ranged from 20 to 80/min,...References1. GALLERFOLKERTSCHLONDORFF MVD. Reversible acute renal insufficiency and hyperkalemia following indomethacin therapy. JAMA. 1981;246:154-5. CrossrefMedlineGoogle Scholar2. FINDLINGBECKSTROMRAWSTHORNEKOZINITSKOVITZ JDLFH. Indomethacin-induced hyperkalemia in three patients with gouty arthritis. JAMA. 1980;244:1127-8. CrossrefMedlineGoogle Scholar3. BREZINKATZSCHWARTZCHINITZ JSAJ. Reversible renal failure and nephrotic syndrome associated with nonsteroidal antiinflammatory drugs. N Engl J Med. 1979;301:1271-3. CrossrefMedlineGoogle Scholar4. TANSHAPIROFRANCOSTOCKARDMULROW SRRHP. Indomethacin-induced prostaglandin inhibition with hyperkalemia: a reversible cause of hyporeninemic hypoaldosteronism Ann Intern Med. 1979;90:783-5. LinkGoogle Scholar5. WIDSTROM A. Influence of indomethacin on glucose-induced insulin response in normal man: role of prostaglandins in the rapid insulin release? Horm Metab Res. 1977;9:172-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL A. FRAIS, M.D.; ELLEN D. BURGESS, M.D.; L. BRENT MITCHELL, M.D.Affiliations: Foothills Hospital University of Calgary Calgary, Alberta Canada T2N 2T9 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPiroxicamManagement of Hyperuricemia and GoutHyperkalemia in the elderlyEffects of Age on the Pharmacokinetics of Piroxicam in RatsNon-steroidal anti-inflammatory drugs and acute renal disease: A case control studyDrug-Induced Renal DisordersEffects of Piroxicam on Natriuresis and Kaliuresis in Hypertensives and Healthy VolunteersToxic interactions between lithium and non-steroidal anti-inflammatory drugsDrug-Induced Parenchymal Renal Disease in OutpatientsAdverse Reactions of PiroxicamIncidence of serious side-effects from non-steroidal anti-inflammatory drugs (NSAIDs) in the USAInterstitial nephropathies and pyelonephritis in the agedOnce-daily oxaprozin and piroxicam compared in osteoarthritisAntiinflammatory and Immunosuppressive Drugs in the Treatment of Rheumatoid ArthritisEffects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal functionPiroxicam-induced acute renal failure (anuria)Interstitial nephritis, proteinuria, and renal failure caused by nonsteroidal anti-inflammatory drugsAntiinflammatory analgesics and durgs used in rheumatoid arthritis and gout 1 July 1983Volume 99, Issue 1Page: 129-130KeywordsAcute renal failureAnginaCerebrovascular diseasesDyspneaFolic acidHeart rateHypertensionNSAIDsRenal failureRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 July 1983 PDF downloadLoading ...