Plasmapheresis Therapy in Macroglobulinemia
Authors: ALAN SOLOMON
Journal: Annals of Internal Medicine (1963)

Article1 May 1963Plasmapheresis Therapy in MacroglobulinemiaALAN SOLOMON, M.D., JOHN L. FAHEY, M.D.ALAN SOLOMON, M.D.Search for more papers by this author, JOHN L. FAHEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-5-789 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDeath or disability of a patient with malignant disease may result from direct growth of the tumor or from the elaboration of some harmful product. In the latter instance it should be possible to alter the disease course by modification or removal of the offending substance. At the present time, however, there are a few situations where a deleterious substance present in an excessive amount can be removed in a practicable way. In polycythemia vera, reduction of red blood cell mass by removal of whole blood is a standard form of therapy (1). In primary (Waldenström's) macroglobulinemia, removal of the...References1. DAMESHEK W: Editorial. The treatment of polycythemia. Blood 1: 256, 1946. CrossrefGoogle Scholar2. SKOOGADAMS WAWS: Plasmapheresis in case of Waldenström's macroglobulinemia. Clin. Research 7: 96, 1959. Google Scholar3. SKOOGADAMSCOBURN WAWSJW: Metabolic balance study of plasmapheresis in a case of Waldenström's macroglobulinemia. Blood 29: 425, 1962. CrossrefGoogle Scholar4. SCHWABFAHEY PJJL: Treatment of Waldenström's macroglobulinemia by plasmapheresis. New Engl. J. Med. 263: 574, 1960. CrossrefMedlineGoogle Scholar5. FAHEY JL: Studies of anomalous γ, -β2A-and γ1-macroglobulins. J. Biol. Chem. 237: 440, 1962. CrossrefMedlineGoogle Scholar6. FAHEYBOGGS JLDR: Serum protein changes in malignant diseases. I. the acute leukemias. Blood 16: 1479, 1960. CrossrefMedlineGoogle Scholar7. SCHWABOKUNFAHEY PJEJL: Reversal of retinopathy in Waldenström's macroglobulinemia by plasmapheresis. Arch. Ophthal. (Chicago) 64: 515, 1960. CrossrefMedlineGoogle Scholar8. KLIMANGAYDOSSCHROEDERFREIREICH ALALREJ: Repeated plasmapheresis of blood donors as a source of platelets. Blood 18: 303, 1961. CrossrefMedlineGoogle Scholar9. CLINESOLOMONBERLINFAHEY MJANIJL: Anemia in macroglobulinemia. Amer. J. Med. 34: 213, 1963. CrossrefMedlineGoogle Scholar10. STERLING K: The turnover rate of serum albumin in man as measured by I131-tagged albumin. J. Clin. Invest. 30: 1228, 1951. CrossrefMedlineGoogle Scholar11. GITLINJANEWAYFARR DCALE: Studies on the metabolism of plasma proteins in the nephrotic syndrome. I. Albumin, γ-globulin and iron-binding globulin. J. Clin. Invest. 35: 44, 1956. CrossrefMedlineGoogle Scholar12. SOLOMONWALDMANNFAHEY ATJL: Metabolism of normal 6.6 S γ-globulin in normal subjects and in patients with macroglobulinemia and multiple myeloma. J. Lab. Clin. Med. In press. Google Scholar13. COHENFREEMAN ST: Metabolic heterogeneity of human γ-globulin. Biochem. J. 76: 475, 1960. CrossrefMedlineGoogle Scholar14. WALDENSTRÖM J: Incipient myelomatosis or "essential" hyperglobulinemia with fibrinogenopenia—a new syndrome? Acta Med. Scand. 117: 216, 1944. CrossrefGoogle Scholar15. WALDENSTRÖM J: Die Makroglobulinamie. Ergben. Inn Med. Kinderheilk. 9: 591, 1958. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Metabolism Service, National Cancer Institute, National Institutes of Health, United States Public Health Service, Department of Health, Education, and Welfare, Bethesda 14, Maryland.This paper was presented at the Forty-third Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 9-13, 1962.Requests for reprints should be addressed to John L. Fahey, M.D., Metabolism Service, National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland. 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HemapheresisPLASMA EXCHANGE IN THE TREATMENT OF SEVERE, CHILDHOOD ONSET SYSTEMIC LUPUS ERYTHEMATOSUSPlasma Exchange and Moderate Dose of Cytostatics in Advanced Macro(cryo)globulinemiaNational center for health care technology assessment of therapeutic apheresis for rheumatoid arthritis, 1981The hemostatic system in children undergoing intensive plasma exchangePlasma Exchange in the Treatment of Immune Complex DiseasePlasma exchange in systemic lupus erythematosus.Plasmapheresis: A pediatric perspectivePlasma ExchangeAdvances in the use of therapeutic pheresis for the management of rheumatic diseasesHyperviscosity syndrome associated with an idiopathic monoclonal IgA-rheumatoid factorBlood rheology.Plasmapheresis-Bloodletting Revived and RefinedMonoclonal Immunoglobulins As Biomarkers Of CancerSuccessful treatment by plasmapheresis of respiratory insufficiency in myasthenia gravisPLASMA EXCHANGE: A SELECTIVE FORM OF BLOOD‐LETTINGTherapeutic Plasmapheresis for Collagen DiseasesBiology, Clinical Patterns, and Treatment of Multiple Myeloma and Related Plasma–Cell DyscrasiasKomplikationen und supportive Therapie der Leukämien und malignen Non-Hodgkin-LymphomePlasmapheresis: Great Economy in the Use of HorsesEffect of plasma exchange on circulating immune complexes and antibody formation in patients treated with cyclophosphamide and prednisoneOtolaryngological disturbances in Waldenstrom's macroglobulinaemiaPLASMAPHERESIS IN MACROGLOBULINÆMIAMultiple Myeloma and Primary Macroglobulinemia (Waldenström)Positional Nystagmus in Association with MacroglobulinemiaKlinik und Therapie des Morbus Waldenström und der H-Ketten-ErkrankungenSjögren's Syndrome: Hyperviscosity and Intermediate ComplexesWILLIAM M. BLAYLOCK, M.D., MARION WALLER, Ph.D., DAVID E. NORMANSELL, Ph.D.Paraproteinämische HämoblastosenErfahrung mit der Procarbazintherapie bei Morbus WaldenströmImmunoglobulin Disturbances and Their Clinical SignificanceCRYOGENIC DISEASESThe Pathology Of Sudden DeafnessAggregation phenomenon in an IgG multiple myeloma resulting in the hyperviscosity syndromePlasmapheresis in Acute Pulmonary EdemaRetinal Circulation in the Hyperviscosity SyndromeSyndromes of HyperviscosityA lambda light chain cold agglutinin-cryomacroglobulin occurring in Waldenström's macroglobulinemiaSafety and Long-term Effects of PlasmapheresisBIBLIOGRAPHYTherapeutic Plasmapheresis in Treatment of Patients with Waldenström's MacroglobulinemiaIntense plasmapheresis in the pregnant Rh-sensitized womanMacroglobulinemia and vasculitis in Sjögren's syndromePrimary macroglobulinemiaM-proteins, plasmacytosis and cancerUltrastructure of the Fibrin ClotThe Treatment of Plasma Cell MyelomaTurnover of 131I-labeled Autologous Macroglobulin in Waldenström's Macroglobulinemia Report of a Case Studied During Treatment with Phenylalanine MustardPATRICIA WILKINSON, M.D., F.R.C.P., WARREN DAVIDSON, M.D., AMORY SOMMARIPA, M.D.Waldenström's macroglobulinemiaREFERENCESAggregation of IgG globulin in vivoDie hämorrhagischen DiathesenMacroglobulinemiaSerum protein disorders causing clinical symptoms in malignant neoplastic disease 1 May 1963Volume 58, Issue 5Page: 789-800KeywordsBlindnessDisabilitiesElectroencephalographyHemorrhageMedical servicesNeurologyOphthalmologyPolycythemia veraPrevention, policy, and public healthRed blood cells ePublished: 1 December 2008 Issue Published: 1 May 1963 PDF downloadLoading ...