Gram-Positive Infections and Quinolones in Neutropenia
Authors: Javier Altclas
Journal: Annals of Internal Medicine (1997)

Letters15 May 1997Gram-Positive Infections and Quinolones in NeutropeniaJavier Altclas, MD, Patricia Costantini, MD, and Miguel Dictar, MDJavier Altclas, MDInstituto de Criopreservacion y Transplante de Medula Osea IMA, Buenos Aires, ArgentinaInstituto de Oncologi Angel Roffo, Buenos Aires, ArgentinaInstituto de Alexander Fleming, Buenos Aires, ArgentinaSearch for more papers by this author, Patricia Costantini, MDInstituto de Criopreservacion y Transplante de Medula Osea IMA, Buenos Aires, ArgentinaInstituto de Oncologi Angel Roffo, Buenos Aires, ArgentinaInstituto de Alexander Fleming, Buenos Aires, ArgentinaSearch for more papers by this author, and Miguel Dictar, MDInstituto de Criopreservacion y Transplante de Medula Osea IMA, Buenos Aires, ArgentinaInstituto de Oncologi Angel Roffo, Buenos Aires, ArgentinaInstituto de Alexander Fleming, Buenos Aires, ArgentinaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-10-199705150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the recent article by Bow and colleagues [1] on quinolone prophylaxis. The authors showed that the patients who received ofloxacin plus rifampin had fewer documented infections than patients who received other prophylactic regimens. However, these results were hampered by an increased rate of fevers of unknown origin. The authors also noted a high rate of yeast colonization (71%) in their patients. Only 6 of 31 patients were colonized by gram-negative rods; data on the susceptibility of these organisms are not available. The rate of febrile neutropenia and mortality were similar among the three ...References1. Bow EJ, Mandell LA, Louie TJ, Feld R, Palmer M, Zee B. et al. Quinolone-based antibacterial chemoprophylaxis in neutropenic patients: effect of augmented gram-positive activity on infectious morbidity. Ann Intern Med. 1996; 125:183-90. Google Scholar2. Pizzo PA, Robichaud KJ, Gill FA, Witebsky FG, Levine AS, Deisseroth AB, et al. Duration of empiric antibiotic therapy in granulocytopenic patients with cancer. Am J Med. 1979; 67:194-200. Google Scholar3. Uzun O, Anaissie EJ. Antifungal prophylaxis in patients with hematological malignancies: a reappraisal. Blood. 1995; 86:2063-72. Google Scholar4. Altclas J, Dictar M, Dignani C, Salgueira C, Veron T. Arduino S, et al. Oral quinolones prophylaxis: evaluation of aerobic gram-negative bacteremia in 578 bone marrow transplant patients [Abstract]. Proceedings of the Ninth Internal Symposium on Infections in the Immunocompromised Host. Assisi, Italy; 1996. Google Scholar Author, Article, and Disclosure InformationAuthors: Javier Altclas, MD; Patricia Costantini, MD; Miguel Dictar, MDAffiliations: Instituto de Criopreservacion y Transplante de Medula Osea IMA, Buenos Aires, ArgentinaInstituto de Oncologi Angel Roffo, Buenos Aires, ArgentinaInstituto de Alexander Fleming, Buenos Aires, Argentina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1997Volume 126, Issue 10Page: 830KeywordsAntibioticsFeversMortalityNeutropeniaProphylaxisPseudomonas aeruginosaPseudomonas infectionsRandomized trialsToxinsYeast infections ePublished: 15 August 2000 Issue Published: 15 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...