tbuckley/cabot-search huggingface dataset:
The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor
Authors: Babs O. Fabriek, Machteld M. J. Polfliet, Rianka P. M. Vloet, Roel C. van der Schors, Antoon J. M. Ligtenberg, Lehn K. Weaver, Christiaan Geest, Kenjiro Matsuno, Søren K. Moestrup, Christien D. Dijkstra, Timo K. van den Berg
Journal: Blood (2007)
Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura
Authors: Hendrik B. Feys, Inge Pareyn, Renee Vancraenenbroeck, Marc De Maeyer, Hans Deckmyn, Chris Van Geet, Karen Vanhoorelbeke
Journal: Blood (2009)
REMOVING DEEP SUTURES
Authors: Frederick L. Smith
Journal: JAMA (1924)

The removal of deep retention sutures is a painful ordeal; "worse than the operation" is a common expression of patients on whom laparotomy has been performed. The deep silkworm sutures that are used in the Mayo Clinic are placed as supportive retention sutures, and are usually removed on the fourteenth day following operation. Frequently the suture adheres to the tissues and requires considerable traction in removal, with consequent pain. Occasionally the suture breaks, leaving the last half in the tissues; this not only causes the patient great discomfort and concern, but is a source of anxiety to the surgeon, who does not know whether it will fibrose, or whether it will cause a suppurative process later. In order to avoid such a sequel I instruct the patient to execute deep abdominal breathing, and then by gentle traction, remove the suture on inspiratory and occasionally on expiratory movement of the abdominal
Drug points: Membranous glomerulopathy associated with carbemazepine
Authors: L D Hordon, J H Turney
Journal: BMJ (1987)

The report by Dr M K Albazzaz and others (13 December, p 1537) sheds light on a recent case of a 38 year old man with ankylosing spondylitis admitted to the renal unit in oligoanuric renal failure (creatinine 800 [tmol/l).He had been taking azapro- pazone 600 mg daily for the previous 12 months.Ultrasound examination showed normal sized kid- neys, and a renal biopsy showed only areas of focal interstitial fibrosis.The azapropazone was withdrawn and after dietary management his renal function recovered to a creatinine clearance of 30 ml/min.Acute renal failure has been reported in patients who developed acute pyelonephritis while taking non- steroidal anti-inflammatory agents (including azapro- pazone),I and the interactions between non-steroidal anti-inflammatory drugs and the kidneys have been reviewed.2The mechanism of our patient's mild chronic renal impairment was presumably drug in- duced interstitial fibrosis,3 but in view of the above report and the lack of evidence of glomerular or tubular damage on renal biopsy the pathogenesis of his acute episode is likely to have been allergic.Extreme care is needed in evaluating the risk-benefit ratio when prescribing non-steroidal anti-inflammatory agents.1 Atkinson LK, Goodship THJ, Ward MK.Acute renal failure associated with acute pyelonephritis and consumption of non- steroidal anti-inflamnatory drugs.
Cerebral function before and after carotid endarterectomy.
Authors: P M Perry, J E Drinkwater, G W Taylor
Journal: BMJ (1975)

Twenty men had their cerebral function measured preoperatively and three months after carotid endarterectomy using the Halstead-Reitan neuropsychological test battery. Thirteen patients were cerebrally impaired preoperatively, but 12 of them improved appreciably after surgery. Changes in internal carotid arterial blood flow measured preoperatively showed no significant correlation with the improvement in neuropsychological status. We think that carotid endarterectomy carries an even better prophylaxis for the brain as a whole than had been thought.
Sonographically Guided Percutaneous Renal Interventional Procedures
Authors: Rosalyn Kutcher
Journal: JAMA (1984)

THE INCREASING use of percutaneous aspiration techniques has led to a variety of alternatives to surgical procedures for patients with diagnostic problems relating to the kidney and perirenal areas. The accessibility of the genitourinary tract to ultrasound and the absence of radiation afforded by its use make ultrasound a desirable modality for a number of interventional procedures. Table 1 lists the spectrum of diagnostic and therapeutic interventional procedures performed under sonographic guidance at the Montefiore Medical Center from 1975 to May 1983. <h3>Renal Biopsy</h3> The kidney was one of the first organs to be selected for percutaneous biopsy. In the past 30 years, the superiority of percutaneous biopsy over open biopsy has been well established for its high yield and low morbidity.<sup>1</sup>Both ultrasonic and fluoroscopic localization techniques are considered equal in accuracy. Ultrasound is advantageous because it is a gross anatomic examination and does not depend on renal
Differential block of cardiac delayed rectifier current by class Ic antiarrhythmic drugs: evidence for open channel block and unblock
Authors: C. H Follmer, C. A Cullinan, T. J Colatsky
Journal: Cardiovascular Research (1992)

The aim was to compare the effects of the class Ic antiarrhythmic drugs flecainide, encainide, and recainam on the delayed rectifier current, IK.Membrane currents were studied using the single suction pipette voltage clamp technique in freshly dissociated cat ventricular myocytes bathed in HEPES buffered physiological saline at 32 degrees C.Flecainide and encainide decreased IK with IC50 values of 2.1 microM and 6 microM, respectively. Recainam (100 microM) reduced IK by only 7 (SEM 3)% after 20-30 min exposure and by 19% after an 80 min exposure (IC50 > 400 microM). None of the compounds blocked the inward rectifier, IK1. Block of IK by flecainide and encainide increased with depolarisation following a voltage dependence similar to that describing channel activation. Flecainide and encainide also slowed the time course of the IK tail currents, consistent with drug dissociating from open channels.The observed voltage dependence for IK block by flecainide and encainide resembles the interaction reported between these agents and the excitatory sodium channel, ie, depolarisation enhances block while repolarisation leads to removal of block. The results further suggest that the electrophysiological profile of class Ic agents can have a markedly different ionic basis, ie, K+ channel block by flecainide and encainide is balanced by a potent block of sodium channels, while recainam appears to be a weak but relatively specific blocker of sodium channels only. These differences are not readily accommodated by the current Harrison-Vaughan-Williams classification scheme, and suggest the possibility that potentially important drug specific differences can exist within the same antiarrhythmic drug class.
Treatment of hyponatraemic seizures with intravenous 29.2% saline.
Authors: L I Worthley, P D Thomas
Journal: BMJ (1986)

Five patients with severe hyponatraemia and epileptiform seizures were given 50 ml of 29.2% saline (250 mmol) through a central venous catheter over 10 minutes to control seizures rapidly, reduce cerebral oedema, and diminish the incidence of permanent neuronal damage. The saline controlled seizures in all patients, increasing the mean serum sodium concentration by 7.4 (SD 1.14) mmol(mEq)/l and decreasing the mean serum potassium concentration by 0.62 (0.5) mmol(mEq)/l. Further saline and frusemide were then administered over 10 (2) hours, raising the serum sodium concentration by 2.14 (0.49) mmol/l/h until it reached 133 (2.35) mmol/l. A total of 790 (139) mmol saline was infused and a negative fluid balance of 3.34 (0.75) litres achieved. Four patients survived without neurological abnormality. One patient, who was not treated immediately and suffered a prolonged episode of status epilepticus, was left with a permanent neurological defect.
Chief Resident Operative Experience
Authors: Karen Deveney
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
STUDIES ON THE PHYSIOLOGICAL EFFECTS OF FEVER TEMPERATURES
Authors: Charles M. Carpenter, Ruth A. Boak, Stafford L. Warren
Journal: The Journal of Experimental Medicine (1932)

1. Multiple, unsustained fevers (41-42 degrees C.) produced by irradiation in a high frequency electrostatic field (10,000 kilocycles) destroyed T. pallidum in rabbits with active syphilitic lesions as determined by the injection into normal rabbits of extracts prepared from their testes and popliteal lymph nodes. 2. One febrile period of 6 hours at a temperature of 41.5-42 degrees C. was likewise found to be sufficient to destroy T. pallidum. 3. Infection with T. pallidum persisted in a control series of untreated rabbits for as long as 395 days after inoculation, but clinical healing occurred in from 3 to 4 months after injection. 4. The time interval between inoculation and fever treatment, or between the end of the fever treatment and reinoculation, did not affect the results. 5. The fever treatment was effective at any stage of experimental syphilis in rabbits.
Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis
Authors: F ROUSSET, J ROBERT, M ANDARY, J BONNIN, G SOUILLET, I CHRETIEN, F BRIERE, J PENE, J DEVRIES
Journal: Journal of Allergy and Clinical Immunology (1991)
The p21<sup>Cip1</sup>protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers
Authors: Maribel Jaime, Maria Jessús Pujol, Joan Serratosa, Cristina Pantoja, Núria Canela, Oriol Casanovas, Manuel Serrano, Neus Agell, Oriol Bachs
Journal: Hepatology (2002)

Liver cells from p21 Cip1−/− mice subjected to partial hepatectomy (PH) progress into DNA synthesis faster than those from wild-type mice. These cells also show a premature induction of cyclin E/cyclin-dependent kinase (CDK) 2 activity. We studied the mechanisms whereby cells lacking p21 Cip1 showed a premature induction of this activity. Whereas the levels of CDK2, cyclin E, and p27 Kip1 were similar in both wild-type and p21 Cip1−/− mice, those of the activator CDC25A were much higher in p21 Cip1−/− quiescent and regenerating livers than in wild-type animals. Moreover, p21 Cip1−/− cells also showed a premature translocation of CDC25A from cytoplasm into the nucleus. The ectopic expression of p21 Cip1 into mice embryo fibroblasts from p21 Cip1−/− mice decreased the levels of CDC25A and delayed its nuclear translocation. The levels of CDC25A messenger RNA in p21 Cip1−/− cells were higher than in wild-type cells, suggesting that this increase might be responsible, at least in part, for the high levels of CDC25A protein in these cells. Thus, the results reported here indicate that p21 Cip1 regulates the levels and the intracellular localization of CDC25A. We also found a good correlation between CDC25A nuclear translocation and cyclin E/CDK2 activation. In conclusion, premature translocation of CDC25A to the nucleus might be involved in the advanced induction of cyclin E/CDK2 activity and DNA replication in cells from animals lacking p21 Cip1 .
Right aortic arch associated with Kommerell’s diverticulum and aberrant left subclavian artery: an unusual cause of dysphagia
Authors: K.-C. Cheng, H.-H. Chiu, C.-C. Huang
Journal: Endoscopy (2009)

A 60-year-old man presented with a 2-day history of fever, chill, and swelling of the left knee. There had been occasional dysphagia to solids during the previous 1 year. Aspirate from the left knee showed an elevated white cell count, but no bacteria. Chest radiograph showed widening of the upper mediastinum. Upper gastrointestinal endoscopy showed extrinsic compression of the upper thoracic esophagus with normal overlying mucosa ([Fig. 1]).
Zaida Mary Hall
Authors: N. Hall
Journal: BMJ (2013)

An only child, Zaida Megrah was educated at St Paul’s Girls School in London and then read medicine at Oxford and subsequently at St George’s Hospital, where she was one of the first female medical students. She wrote her doctorate on the fate and action of vitamin B12 in pernicious anaemia and then trained to be a chest physician. She joined the Bach Choir while in London and sang with the choir for more than 40 years. There she met Ruthven Hall, and they married in 1950. When he became bursar of Winchester College the couple moved to Winchester, and, …
TREATMENT OF INTRACTABLE PEPTIC ULCER WITH METHANTHELINE (BANTHINE®) BROMIDE
Authors: Daniel Liebowitz
Journal: JAMA (1952)

Since methantheline (banthine®) bromide was first used in the treatment of patients with peptic ulcer, many enthusiastic reports of its therapeutic value have appeared in the literature. Most studies reported were short-term evaluations of not more than a few weeks or months.<sup>1</sup>Others were done for longer periods, some as follow-ups on preliminary reports.<sup>2</sup>The authors of many of these reports have stressed the prompt symptomatic response to the drug. Healing of ulcer craters has also been frequently observed. Little has been mentioned, however, regarding the development in patients of tolerance to a maintenance dose of the drug or of their relapse while taking the drug. While most investigators have recommended that a standard dose of the drug should be employed, there has been some disagreement as to the amounts that should be used in therapy and in maintenance.<sup>3</sup>Conflicting reports concerning the effect of methantheline
How journals identify their contents
Authors: B. Aronson, M. Thuriaux
Journal: BMJ (1992)

comments of the Joint Committee for Postgraduate Training in General Practice in its report for Dudley and Sandwell, which highlighted this as a potential difficulty.We organised a weekend course for all the trainers to learn how to interview, with an appreci- able input from non-medical people.It became clear that our interviewing skills were poor, and as a result we rethought the whole way of interview- ing potential trainees.Rodger wrote the seminal work on this subject in 1952,4 and it has been reiterated by others more recently.56As a result, we have reduced our interviewing panel from 12-18 to four-two consultants and two general practice trainers-with a neutral chairman.This is a much less intimidating ordeal, but the questioning is no less probing for this change.The reduction ofinterviewers means that those involved in the training scheme but not invited to interview candidates have to trust the panel.We believe that this change has considerably improved the interviewing procedure.It has already worked well in the Dudley scheme, and we strongly recommend it to other interviewing panels.We must recognise that we have a lot to learn from non-medical experts when it comes to interviewing procedure.
Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program
Authors: Maarten Hoogenkamp, Monika Lichtinger, Hanna Krysinska, Christophe Lancrin, Deborah Clarke, Andrew Williamson, Luca Mazzarella, Richard Ingram, Helle Jorgensen, Amanda Fisher, Daniel G. Tenen, Valerie Kouskoff, Georges Lacaud, Constanze Bonifer
Journal: Blood (2009)
A Scheme for the Care of the Aged and Chronic Sick
Authors: T. McKeown, C. R. Lowe
Journal: BMJ (1952)

amount of disinterested advice will avail to alter them.Moreover, advice of this sort is a policy of despair, robbing the patient of all joy in life.Rather he should be fortified by encouragement, assured that the future is by no means devoid of hope, and advised to live as actively as his health permits.
GW25-e5349 Nebivolol Protects against Myocardial Infarction Injury via Stimulation of beta 3-Adrenergic Receptors and Nitric Oxide Signaling
Authors: Zhang Zheng, Liping Ding, Zhitao Jin, Guojie Gao, Taohong Hu
Journal: Journal of the American College of Cardiology (2014)
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
Authors: Richard S Houlston, Jeremy Cheadle, Sara E Dobbins, Albert Tenesa, Angela M Jones, Kimberley Howarth, Sarah L Spain, Peter Broderick, Enric Domingo, Susan Farrington, James G D Prendergast, Alan M Pittman, Evi Theodoratou, Christopher G Smith, Bianca Olver, Axel Walther, Rebecca A Barnetson, Michael Churchman, Emma E M Jaeger, Steven Penegar, Ella Barclay, Lynn Martin, Maggie Gorman, Rachel Mager, Elaine Johnstone, Rachel Midgley, Iina Niittymäki, Sari Tuupanen, James Colley, Shelley Idziaszczyk, Huw J W Thomas, Anneke M Lucassen, D Gareth R Evans, Eamonn R Maher, Timothy Maughan, Antigone Dimas, Emmanouil Dermitzakis, Jean-Baptiste Cazier, Lauri A Aaltonen, Paul Pharoah, David J Kerr, Luis G Carvajal-Carmona, Harry Campbell, Malcolm G Dunlop, Ian P M Tomlinson
Journal: Nature Genetics (2010)
Silver poisoning associated with an antismoking lozenge.
Authors: D Shelton, R Goulding
Journal: BMJ (1979)

demand expertise.If this is lacking then expert supervision should be at hand.When this is not available, as in practical terms it may not be, then how much wiser it is to stop well short of that critical force.A trial of forceps therefore should still be a laudable and well-recognised procedure, and a "failed forceps" never regarded as an obstetric failure, unless the danger force is exceeded.No amount of experience will always predict the outcome of every instrumental delivery.Perhaps in the electronic age we could design a special type of strain gauge attached to the forceps handles.Failing this, a change in some attitudes towards trials of forceps, and in particular failed forceps, could certainly help.
The Diagnostic Dilemma of Severe Staphylococcal Infections
Authors: ROBERT I. WISE
Journal: Annals of Internal Medicine (1961)

Editorials1 August 1961The Diagnostic Dilemma of Severe Staphylococcal InfectionsROBERT I. WISE, M.D., PH.D.ROBERT I. WISE, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-2-344 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs the growth of medical knowledge becomes more complex, the hazard arises that the clinician may lose touch with basic principles of the medical sciences. A paper in this issue of the ANNALSby Woodley and Hall (1) reports on the management of the difficult problem of severe staphylococcal infections with vancomycin. Before an effective program of management of this often fatal disease can be started with confidence, the clinician requires accuracy of diagnosis. These serious infections present a challenging problem to modern medicine in diagnosis and management needed to reduce the fatality rate and expense of prolonged stay in...Reference1. WOODLEYHALL DWWH: The treatment of severe staphylococcal infections with vancomycin. Ann. Intern. Med. 55: 235, 1961. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Jefferson Medical College 1025 Walnut Street Philadelphia 7, Penna. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1961Volume 55, Issue 2Page: 344-346KeywordsStaphylococcal infectionTouchVancomycin Issue Published: 1 August 1961 PDF DownloadLoading ...
Left ventricular unloading during reperfusion does not limit myocardial infarct size.
Authors: D M Van Winkle, T Matsuki, N M Gad, M C Jordan, J M Downey
Journal: Circulation (1990)

To determine whether venting the left ventricle during coronary reperfusion limits myocardial infarct size, we studied paced (200 beats/min) Langendorff rabbit hearts, perfused with blood from a support rabbit. A left coronary artery was occluded for 60 minutes, followed by 2 hours of reperfusion. Four experimental conditions, as follows, were used: In group 1 (control), the hearts contracted isovolumetrically on a fluid-filled balloon in the left ventricle during both occlusion and reperfusion. In group 2, the balloon was present only during occlusion, and the heart was vented during reperfusion. Hearts in group 3 were vented during occlusion and developed pressure during reperfusion. In group 4, the left ventricle was vented during occlusion and reperfusion. Perfusion pressure (91.2 +/- 0.9 mm Hg) and coronary flow (0.88 +/- 0.03 ml/min/g) were not different between groups. Left ventricular pressures (mean of all groups) were 87.3 +/- 1.5 mm Hg systolic and 6.5 +/- 0.6 mm Hg diastolic. Infarcted myocardium was assessed by triphenyl tetrazolium staining and expressed as a percentage of the area at risk, as measured by fluorescent particles. Venting during both ischemia and reperfusion (n = 10) did result in significantly smaller infarcts than in the unvented controls (n = 10), that is, 13 +/- 5% vs. 41 +/- 6%, respectively. Venting only during reperfusion (n = 10) or occlusion (n = 11) did not significantly limit infarct size (57 +/- 6% and 32 +/- 5%, respectively), as compared with controls. Thus, the clinically feasible intervention of left ventricular venting during reperfusion was not cardioprotective.