tbuckley/cabot-search huggingface dataset:
Mental Illness and Susceptibility to Motion Sickness
Authors: CHARLES S. MIRABILE
Journal: American Journal of Psychiatry (1972)

In attempting to explore the relationship between orienting mechanisms and behavior, the incidence of motion sickness in various diagnostic categories was determined and a meaningful diagnostic continuum was constructed. Through examination of unilateral versus bilateral seizure disturbances in one subgroup, it was possible to infer differences in interhemispheric access at the extremes of vestibular sensitivity, thus raising questions about underlying organization of brain function and behavior.
Characterization of the Mismatch Repair Defect in the Human Lymphoblastoid MT1 Cells
Authors: Marta Szadkowski, Ingram Iaccarino, Karl Heinimann, Giancarlo Marra, Josef Jiricny
Journal: Cancer Research (2005)

Abstract Mutations in mismatch repair (MMR) genes predispose to hereditary nonpolyposis colon cancer. Those leading to truncated proteins bring about a MMR defect, but phenotypes of missense mutations are harder to predict especially if they do not affect conserved residues. Several systems capable of predicting the phenotypes of MMR missense mutations were described. We deployed one of these to study the MMR defect in MT1 cells, which carry mutations in both alleles of the hMSH6 gene. In one, an A→T transversion brings about an Asp(1213)Val amino acid change in the highly conserved ATP binding site, whereas the other carries a G→A transition, which brings about a Val(1260)Ile change at a nonconserved site. The hMSH2/hMSH6 (hMutSα) heterodimers carrying these mutations were expressed in the baculovirus system and tested in in vitro MMR assays. As anticipated, the Asp(1213)Val mutation inactivated MMR by disabling the variant hMutSα from translocating along the DNA. In contrast, the recombinant Val(1260)Ile variant displayed wild-type activity. Interestingly, partial proteolytic analysis showed that this heterodimer was absent from MT1 extracts, although both hMSH6 alleles in MT1 cells could be shown to be transcribed with an efficiency similar to each other and to that seen in control cells. The MMR defect in MT1 cells is thus the compound result of one mutation that inactivates the ATPase function of hMutSα and a second mutation that apparently destabilizes the Val(1260)Ile hMSH6 protein in human cells in vivo.
Theophylline Toxicity and Nifedipine
Authors: CHARLES SCOTT HARROD
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 March 1987Theophylline Toxicity and NifedipineCHARLES SCOTT HARROD, M.D.CHARLES SCOTT HARROD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-480_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Elevated theophylline blood levels and frank toxicity precipitated by the addition of many medicines, most notably Cimetidine and erythromycin, have been well documented. Recently, I saw a patient who developed frank theophylline toxicity after the addition of Procardia (nifedipine; Pfizer, Inc., New York, New York) therapy. An extensive search done on MEDLINE showed reference only to increased theophylline concentrations after the addition of oral verapamil (1) and one case after the addition of nifedipine (2). No other cases have been reported in the literature, and none document the recurrence of toxicity after rechallenge. I then informed Pfizer...References1. BURNAKISSELDONCZAPLICKI TMA. Increased serum theophylline concentration secondary to oral verapamil. Clin Pharmacol. 1983;2:458-61. Google Scholar2. PARRILLOVENTITTO SM. Elevated theophylline blood levels from institution of nifedipine therapy. Ann Emerg Med. 1984;13:216-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES SCOTT HARROD, M.D.Affiliations: San Luis Valley Medical Professional Corporation Alamosa, CO 81101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug Interactions with Agents Used in Respiratory DiseaseNifedipine alters serum theophylline levels in asthmatic patients with hypertensionPharmakologie und antihypertensive Wirksamkeit der KalziumantagonistenCombination therapy has potential complicationsVerapamil-Induced Inhibition of Theophylline Elimination in Healthy HumansSide Effects — Overdosage — Contraindications — Drug InteractionsDrug interactions with calcium antagonistsCalcium Channel Blockers as Inhibitors of Drug MetabolismNebenwirkungen — Überdosierung (Vergiftung) — Kontraindikationen — Arzneimittelinteraktionen 1 March 1987Volume 106, Issue 3Page: 480-480KeywordsAttentionBloodErythromycinTheophylline toxicityToxicity ePublished: 1 December 2008 Issue Published: 1 March 1987 PDF downloadLoading ...
Potentiation of the hemodynamic effects of acutely administered nitroglycerin by methionine.
Authors: W S Levy, R J Katz, R L Ruffalo, R H Leiboff, A G Wasserman
Journal: Circulation (1988)

It is believed that nitroglycerin causes vasodilatation by interacting with sulfhydryl groups present in vascular smooth muscle. This study was performed to assess whether methionine, an amino acid capable of increasing sulfhydryl availability, would potentiate the hemodynamic effects of nitroglycerin. Nitroglycerin was initially infused in incremental doses from 1 to 50 micrograms/min in all patients to determine the dose required to reduce mean arterial pressure by 10% and pulmonary capillary wedge pressure by 30%. After a washout period, 10 patients received 5 g methionine i.v. and five patients received an equal volume of 5% dextrose in water (control). Nitroglycerin dose titration was then repeated. Methionine alone induced no hemodynamic effects, but after methionine infusion, there was a significant reduction in the nitroglycerin infusion rate required to reach each hemodynamic endpoint (p less than 0.01). In the control group, there was no significant change in responsiveness to nitroglycerin between infusions. Thus, methionine potentiates the hemodynamic effects of acutely administered intravenous nitroglycerin.
“Plunging Biopsy”: A New Aimed Bioptic Technique
Authors: V. Casale, A. Grassi, M. Crespi
Journal: Endoscopy (1977)

A new technique for aimed bioptic sampling is described, by which it is possible to obtain satisfactory tissue fragments also with front view instruments and normal forceps in those areas, such as the esophagus and gastric prepyloric lesser curvature, where the bioptic material obtained is often unsuitable for histologic diagnosis.
Complications of transvenous (transjugular) liver biopsy.
Authors: D Lebrec, B Rueff, J P Benhamou
Journal: BMJ (1977)

Whether Drs Brooks and Harrington's patient developed malignancy after the diagnosis of coeliac disease was made and some clinical improvement was obtained after gluten withdrawal or whether it was present initially, precipitating overt manifestations of gluten intolerance, it is not possible to say.It is certainly believed that failure of a patient with newly diagnosed coeliac disease to respond to gluten withdrawal or relapse occurring after previous control by diet is suggestive of the development of malignancy.'The view that intestinal malignancy may cause flattening of the jejunal mucosa and present as "the coeliac syndrome" is no longer held.
Abstract 4637: Cell penetrating antibodies for intracellular targets: Expanding the antibody-based treatments for cancer
Authors: Richard S. Agnes, Masahiro Hitomi, James P. Basilion
Journal: Cancer Research (2012)

Abstract Antibody based therapeutics have gained significant interest in recent years. Herceptin, which targets cell surface protein, have been successful for the treatment of cancer. While antibodies are promising platforms for therapy, antibodies have been limited to targeting cell surface proteins because they cannot penetrate cells. Recently, we have developed cell penetrating antibodies engineered from the conjugation of a cell penetrating peptide (CPP) and an antibody. The CPP-mIgG and CPP-anti-RPA1 IgGs were internalized in cells as observed by fluorescence microscopy. Biological activities of these conjugates were determined and the expected anti-proliferative effects of the CPP-anti-RPA1 were subtly distinguishable from the control CPP-mIgG. While RPA1 is a valid anti-cancer target, its function depends on complicated pathways and cell cycle where dosing may have to be optimized. This demonstrates the difficulties in establishing CPP-IgG as an efficient therapeutic. To demonstrate that CPP-IgG bioconjugates are capable of inducing biological effects, we sought a different intracellular target. Antimitotic drugs are standard cancer chemotherapeutic agents. Recently, other proteins involved in the mitotic machinery have gained much attention. For example, kinesin motor protein Eg5 plays an important role in mitosis and inhibiting Eg5 prevents the formation of bipolar spindles resulting to an unmistakable change of morphology during mitosis_a star-like structure called “monoastral”. Small molecules, such as monastrol and (S)-trityl cysteine (STLC), lead to monastral formation. Thus, we chose Eg5 protein as an intracellular target to demonstrate that CPP-IgG bioconjugates are able to penetrate cells and have neutralizing activity. We expect that CPP-anti-Eg5 conjugates will penetrate cells and produce the canonical inhibition of Eg5 protein by observing for the monoastral morphology during mitosis. We tested whether CPP-anti-Eg5 IgG will present the same biological activity as STLC. We bioconjugated the anti-Eg5 with a CPP. Cell cycle synchronized cells were treated with the positive control STLC and CPP-anti-Eg5 showed an atypical star-like structure similar to monoastral. In whole, these studies show that CPP-IgG against intracellular targets are able to enter the cells and show inhibitory activities. We will describe our progress and discuss approaches to expanding the utility of antibodies as therapeutics for intracellular cancer targets. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4637. doi:1538-7445.AM2012-4637
Exposure to chemicals and systemic sclerosis.
Authors: L Czirjak, Z Csiki, Z Nagy, E Toth
Journal: Annals of the Rheumatic Diseases (1995)

Exposure to chemicals and systemic sclerosisOccupational exposure to various chemicals, including vinyl chloride, silica dust, epoxy resin, benzene, trichloroethylene, perchloro- ethylene, and other solvents, has been described as a potential provoking factor of systemic sclerosis (SSc) and scleroderma like disorders.'However, the precise contribution made by occupational environmental factors to the occurrence of scleroderma remains unknown.
Letter to the editor: Thrombocytosis and erythropoietin‐unresponsive anemia in patients with Castleman's disease
Authors: Masao Mito, Masuhiro Takahashi, Takeshi Suda, Kumiko Yagisawa, Shoji Shinada, Yoshiaki Moriyama, Akira Shibata
Journal: American Journal of Hematology (1991)
Abstract P4-01-15: A high-throughput three-dimensional cell migration assay (BiO assay) for toxicity screening for breast cancer applications
Authors: H Tseng, LG Sabino, WL Haisler, JA Gage, SK Neeley, GR Souza
Journal: Cancer Research (2013)

Abstract Common in vitro assays for drug toxicity screening are not accurate predictors of human in vivo toxicity as they are performed on two-dimensional (2D) surfaces that do not mimic native cellular environments. Three-dimensional (3D) cell culture systems, like magnetic levitation, offer representative culture environments, with spatial control to design assays for drug toxicity applications. In this study, a label-free 3D in vitro assay for high-throughput toxicity screening (BiO Assay) of breast cancer cells was developed. Confluent flasks of cancerous and non-cancerous mammary gland epithelial cells (MDA-231 and MCF-10A) were incubated overnight with a magnetic nanoparticle assembly, to which they bind. The next day, these cells were detached from the flask, and with the external application of a magnetic field, levitated to the air-liquid interface, where cells aggregated and interact to form larger 3D structures. These 3D structures were levitated for 24 hours to induce extracellular matrix formation. Afterwards, the structures were mechanically disrupted and patterned into rings using ring-shaped magnets. The magnetic field was removed, drugs, like doxorubicin, were added at varying concentrations, and the rings were allowed to close. This assay was validated against a 2D viability assay. A mobile device was programmed to capture the rings at specified timepoints, and image analysis was performed to track ring closure as a function of drug concentration and time. MDA-231s and MCF10As were successfully formed into 3D cultures using magnetic levitation, and patterned into rings. We found significantly different results in drug sensitivity between cells grown in 2D and 3D. In conclusion, the BiO Assay is a simple assay that measures drug toxicity in a culture system similar to the native cellular environment. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-01-15.
The neural basis of Imitative behavior: Parietal actions and frontal programs
Authors: Naoyasu Motomura
Journal: Behavioral and Brain Sciences (1998)

Byrne &amp; Russon suggest that there are two kinds of imitation learning – action level and program level – and that the latter is critical for great apes' learning. I have interpreted this phenomenon from the standpoint of clinical neuropsychology and conjecture that action-level imitation might be related to parietal lobe function and program-level imitation might be related to frontal lobe function.
Detection and Quantitation of Intracardiac Left-to-Right Shunts by an Oximetric Inert Gas Technic
Authors: ROBERT C. WOOD, HIRAM W. MARSHALL, EARL H. WOOD
Journal: Circulation (1963)

A method is described for detecting and quantitating small left-to-right shunts by recording continuously and simultaneously the changes in blood oxygen saturation at a systemic artery and at selected sites in the right heart chambers or great vessels produced by a few breaths of an inert gas such as helium or nitrogen. The advantages of this technic for detecting and quantitating left-to-right shunts are (1) the same instrument, namely, the cuvette oximeter, used to determine blood oxygen saturation and indicator-dilution curves in conjunction with routine diagnostic catheterization procedures, also is used to record the inert gas curves, (2) only one right heart catheter is needed, (3) the method is relatively simple, (4) the shunt can be quantitated, and (5) shunts of less than 10 per cent of pulmonary flow can be detected. It is concluded that the technic is of considerable practical value as a means of excluding the presence of or demonstrating and determining the magnitude of small left-to-right shunts.
Factors Affecting the Determination of Uterine Blood Flow in Vivo
Authors: WILLIAM E. HUCKABEE, DONALD H. BAERON
Journal: Circulation Research (1961)

When 4-aminoantipyrine (4AA) was injected into pregnant goats, the time curves of blood concentration could be determined easily and accurately when the injection was carried out over about seven minutes' time. The arterial-and uterine venous-blood concentration curves came together after 15 minutes, and afterward the arteriovenous difference remained negligible. The blood concentration of 4AA gave an accurate estimate of concentrations in the tissue water of the uterus, placenta, and fetus after disappearance of the arteriovenous difference. At the time interval of 15 to 20 minutes, 4AA concentrations in amniotic and allantoic fluids were so low that they could be regarded as negligible. There fore, when 4AA was used as the diffusing substance, the major factors affecting the determination of uterine blood flow by diffusion-equilibration methods were favorable for an estimate of the rate of blood flow per unit weight of metabolically active tissue.
SINGLE NUCLEOTIDE POLYMORPHISMS IN CHROMOSOME 4Q25 PREDICT IN-HOSPITAL AND LONG TERM DEVELOPMENT OF ATRIAL FIBRILLATION AND SURVIVAL IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING
Authors: Salim S. Virani, Ariel Brautbar, Vei-Vei Lee, MacArthur Elayda, Shehzad Sami, Vijay Nambi, Lorraine Frazier, James M. Wilson, James T. Willerson, Eric Boerwinkle, Christie M. Ballantyne
Journal: Journal of the American College of Cardiology (2011)
Thrombocytopenia and Myocardial Ischemia
Authors: Phin Cohen
Journal: JAMA (1974)

Two patients had myocardial ischemia in a setting of chronic thrombocytopenia. Awareness of such occurrences should stimulate the reporting of other cases, so that the role of quantitative changes in platelets on the course of ischemic heart disease may receive greater attention. (<i>JAMA</i>228:1568-1569, 1974)
GPs sent “useless” guidance on coping with possible human cases of bird flu
Authors: Susan Mayor
Journal: BMJ (2007)

GPs near the outbreak of H5N1 avian influenza at a turkey farm in Suffolk, in the east of England, have found the information they have been sent on how to deal with people presenting with symptoms “useless.” A key diagnostic algorithm is difficult to find and the guidance makes no provision for recommended infection control measures, such as the provision for surgical masks. 

In a letter sent to GPs in the area last Monday, the Health Protection Agency (HPA) explained that all the people potentially exposed to H5N1 in the outbreak had “been requested to contact their GP in the event that they experience fever and/or respiratory symptoms.” 

The letter told GPs to assess patients according to a flow chart on the agency's website (www.hpa.org.uk). This advises that people with fever ≥38°C; history of fever …
Regulation of pituitary gonadotropin-releasing hormone receptors by pulsatile gonadotropin-releasing hormone injections in male rats. Modulation by testosterone.
Authors: A Garcia, M Schiff, J C Marshall
Journal: Journal of Clinical Investigation (1984)

The pattern of the gonadotropin-releasing hormone (GnRH) stimulus is critically important in the regulation of pituitary gonadotropin secretion and continuous infusions down-regulate secretion while intermittent pulses maintain luteinizing hormone (LH) and follicle-stimulating hormone (FSH) responsiveness. We examined the effects of pulsatile GnRH administration on pituitary GnRH receptors (GnRH-R) and gonadotropin secretion in the presence of physiological concentrations of testosterone (T) to elucidate the mechanisms and sites of action of GnRH and T on the pituitary gonadotroph. Castrate male rats received one, two, or four testosterone (T) implants (serum T concentrations of 1.1, 2.4, and 5.2 ng/ml, respectively) to suppress endogenous GnRH secretion. Subsequently, intracarotid pulse injections of GnRH (5-250 ng/pulse) or saline in controls were given every 30 min for 48 h, after which gonadotropin responses and pituitary GnRH-R were measured. In control rats, the T implants prevented the rise in GnRH-R that was seen in castrates (empty implant--600 fmol/mg protein) and maintained receptors at the level that was present in intact animals (300 fmol/mg). Pulsatile GnRH administration increased GnRH-R in castrate T-implanted rats, but the response was dependent on the serum T concentration. With one T implant, increasing GnRH doses per pulse stimulated GnRH-R in a linear manner and the maximum receptor concentration (703 +/- 99 fmol/mg) was seen after the 250 ng GnRH dose. In the presence of two T implants, GnRH-R was maximal (705 +/- 45 fmol/mg) after the 25-ng dose and higher doses did not increase receptors above control values. With four T implants, GnRH doses of 5 ng induced a maximum response, 17-50 ng/pulse did not increase GnRH-R, but receptors were again increased by the 250-ng dose (633 +/- 86 fmol/mg). After 48 h of pulsatile GnRH administration there was no correlation between the number of GnRH-R and LH responses to GnRH. In rats with one or two T implants, LH responses were absent after all but the 250-ng doses. In contrast, LH responsiveness was not impaired in the presence of four implants. Thus, low dose GnRH pulses down-regulate LH secretion by an action at a post GnRH-R site, and this effect is regulated by testosterone. The results show that GnRH, given in a pulsatile manner, regulates its own receptor, and physiological increases in serum T produce a 50-fold increase in the sensitivity of GnRH-R stimulation by GnRH.
FEMALE GENDER, LASER SHEATH USE AND OPERATOR SKILL DRIVE THE SUCCESS AND COMPLICATION RATES OF CARDIAC DEVICE LEAD EXTRACTION: AN ACAP REGISTRY ANALYSIS
Authors: Matthew Pierce, Balaji Pratap, Chaithanya Pamidimukala, Joseph Bastawrose, Archana Lingannan, Narmadha Panneerselvam, Adilaxmi Gurram, Dipen Patel, Prachi Kalamkar, Rishad Usmani, Tad Umali, Eyal Herzog, Emad Aziz
Journal: Journal of the American College of Cardiology (2014)
Pretibial Myxedema — A Reversible Cause of Foot Drop Due to Entrapment of the Peroneal Nerve
Authors: Mark Siegler, Samuel Refetoff
Journal: New England Journal of Medicine (1976)

PRETIBIAL myxedema may be cosmetically unattractive but is not believed to have any adverse medical consequence. We recently encountered a patient with Graves's disease in whom bilateral foot drop developed in association with the onset of the infiltrative dermopathy, and disappeared with the resolution of the skin lesion.Case ReportA 64-year-old woman, previously in excellent health, had symptoms of hyperthyroidism for six weeks, and for three weeks had noted progressive weakness of her ankles, with complete inability to walk.Physical examination revealed an anxious woman, whose heart rate was 110 per minute. The thyroid gland was diffusely enlarged and . . .
Current and Future Public Health Challenges
Authors: Jeffrey P. Koplan
Journal: JAMA (2000)

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