UNILATERAL RENAL ISCHEMIA AS A CAUSE OF HYPERTENSION
Authors: PAUL W. CLOUGH
Journal: Annals of Internal Medicine (1959)

Editorial1 January 1959UNILATERAL RENAL ISCHEMIA AS A CAUSE OF HYPERTENSIONPAUL W. CLOUGH, M.D.PAUL W. CLOUGH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-1-232 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe relationship between renal ischemia and hypertension was first clearly demonstrated and brought to general notice by Goldblatt (1934). By applying a clamp to the renal artery so as partially to obstruct the circulation to the kidney, he was able to produce sustained hypertension in some dogs (and also monkeys) which had some clinical resemblance to essential hypertension in man. Release of the clamp or timely removal of the ischemic kidney usually resulted in prompt subsidence of the hypertension if the other kidney was normal. Something instrumental in increasing blood pressure is evidently elaborated or produced in increased quantity by...1 Braun-MenéndezPage EIH: Suggested revision of nomenclature—angiotensin, Science 127: 242, 1958. CrossrefMedlineGoogle Scholar2 BumpusSchwartzPage FMHIH: Synthesis and pharmacology of the octapeptid angiotonin, Science 125: 886, 1957. CrossrefMedlineGoogle Scholar3 KahnSkeggsShumwayWisenbaugh JRLTNPPE: The assay of hypertensin from the arterial blood of normotensive and hypertensive human beings, J. Exper. Med. 95: 523-529, 1952. CrossrefMedlineGoogle Scholar4 Braun-Menéndez E: The prohypertensive and antihypertensive actions of the kidney, Ann. Int. Med. 49: 717-731, 1958. LinkGoogle Scholar5 Smith HW: Unilateral nephrectomy in hypertensive disease, J. Urol. 76: 685-701, 1956. CrossrefMedlineGoogle Scholar6 ThompsonSmithwick JERH: Human hypertension due to unilateral renal disease, with special reference to renal arterial lesions, Angiology 3: 493-505, 1952. CrossrefMedlineGoogle Scholar7 PereraHaelig GAAW: Clinical characteristics of hypertension associated with unilateral renal disease, Circulation 6: 549, 1952. CrossrefMedlineGoogle Scholar8 Deming QB: Association of polyuria and albuminuria with hypertension of unilateral renal origin, Arch. Int. Med. 93: 197-204, 1954. CrossrefGoogle Scholar9 McDonaldSzilagyiSmith RTDERF: Nephrogenic hypertension (Goldblatt kidney) following operative trauma to the renal artery, Circulation 18: 71-75, 1958. CrossrefMedlineGoogle Scholar10 Shackelford RT, quoted by Howard et al.,11 p. 66. Google Scholar11 HowardBerthrongGouldYendt JEBDMER: Hypertension resulting from unilateral renal vascular disease and its relief by nephrectomy, Bull. Johns Hopkins Hosp. 94: 51-85, 1954. MedlineGoogle Scholar12 PoutasseDustan EFHP: Arteriosclerosis and renal hypertension. Indications for aortography in hypertensive patients and results of surgical treatment of obstructive lesions of the renal artery, J. A. M. A. 165: 1521-1525, 1957. CrossrefMedlineGoogle Scholar13 HallerRadiganMorrow JALRAG: Hypertension due to segmental infarction of the kidney, Am. J. Med. 22: 303-305, 1957. CrossrefMedlineGoogle Scholar14 ConnorBerthrongThomasHoward TBMWCJE: Hypertension due to unilateral renal disease—with a report on a functional test helpful in diagnosis, Bull. Johns Hopkins Hosp. 100: 241-276, 1957. MedlineGoogle Scholar15 ImberClymer IRH: Obstruction of the renal artery producing hypertension, New England J. Med. 252: 301, 1955. CrossrefMedlineGoogle Scholar16 McAfeeWillson JGJK: A review of the complications of translumbar aortography, Am. J. Roentgenol. 75: 956-970, 1956. Google Scholar17 Kincaid-Smith P: Vascular obstruction in chronic pyelonephritic kidneys and its relation to hypertension, Lancet 2: 1263, 1955. CrossrefGoogle Scholar18 Winters CC: Unilateral renal disease and hypertension. Use of the radioactive Diodrast renogram as a screening test, J. Urol. 78: 107, 1957. CrossrefMedlineGoogle Scholar19 FreemanLeedsElliottRoland NEFHWGSI: Thromboendarterectomy for hypertension due to renal artery occlusion, J. A. M. A. 156: 1077, 1954. CrossrefMedlineGoogle Scholar20 DeCampBirchall PTR: Recognition and treatment of renal arterial stenosis associated with hypertension, Surgery 43: 134-152, 1958. MedlineGoogle Scholar21 PoutasseHumphriesMcCormackCorcoran EFAWLJAC: Bilateral stenosis of renal arteries and hypertension, J. A. M. A. 161: 419, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL W. CLOUGH, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byÉtude expérimentale du rénogrammeDie Hypertonie bei einseitigen NierenerkrankungenIleorenal RevascularizationI 131 -Diodrast Studies in Unilateral Renal Disease 1 January 1959Volume 50, Issue 1Page: 232-238KeywordsBlood pressureHypertensionKidneysRenal arteriesRenal circulationRenal ischemia ePublished: 1 December 2008 Issue Published: 1 January 1959 PDF downloadLoading ...