tbuckley/cabot-search huggingface dataset:
Todd-Sanford-Davidsohn Clinical Diagnosis and Management by Laboratory Methods
Authors: James W. Allen
Journal: JAMA (1985)

Both medical students and practitioners recognize<i>Todd and Sanford</i>as one of the leading texts in clinical pathology and laboratory medical science. Its newest edition, the 17th, follows the same format as the previous edition, published in 1979, and has the same editor and many of the same contributors. A comparison between the two versions is in order. For the student, the new edition reflects advances made in medical laboratory science in the intervening five years. These changes are evident in all the major chapters: clinical chemistry, microscopy, immunopathology, microbiology, and hematology. Tables that had blank spaces in the 16th edition are now completed in the newest edition. The student will appreciate this newness; however, the book assumes a basic understanding of patholophysiology. For the practitioner, the 17th edition has a clearer clinical orientation than did the previous one. While some contributors display more clinical orientation than others, all chapters
Isolation and partial characterization of allergens from <i>Helianthus annuus</i> (sunflower) pollen
Authors: F. de la Hoz, J. A. Melero, R. González, J. Carreira
Journal: Allergy (1994)

We have purified four allergens from Helianthus annuus (sunflower) pollen, hereafter named as allergens a, b, c, and d. Under native conditions, allergen a has a mol. mass of 32, allergen b has one of 24, and allergens c and d each have one of 55 kDa. At the least, allergens b, c, and d demonstrate charge heterogeneity, and the electrophoretic mobility of allergens c and d increases when these allergens are deglycosylated with trifluoromethanesulfonic acid. Cross-reactivity among the four allergens and with the whole extract is very high, and each allergen recognizes IgE in a high proportion of patients sensitized to sunflower pollen.
HIGH RESOLUTION SYSTEMATIC DIGITAL HISTOLOGICAL QUANTIFICATION OF CARDIAC FIBROSIS AND ADIPOSE TISSUE IN PHOSPHOLAMBAN MUTATION ASSOCIATED CARDIOMYOPATHY
Authors: Johannes M.I.H. Gho, Rene van Es, Nikolas Stathonikos, Magdalena Harakalova, Wouter Te Rijdt, Albert J.H. Suurmeijer, Jeroen F. van der Heijden, Nicolaas de Jonge, Steven Chamuleau, Roel A. de Weger, Folkert W. Asselbergs, Aryan Vink
Journal: Journal of the American College of Cardiology (2014)
CD4-CD8- T cell receptor alpha beta T cells: generation of an in vitro major histocompatibility complex class I specific cytotoxic T lymphocyte response and allogeneic tumor rejection.
Authors: M Mieno, R Suto, Y Obata, H Udono, T Takahashi, H Shiku, E Nakayama
Journal: The Journal of Experimental Medicine (1991)

The generation of an in vitro major histocompatibility complex class I specific response of CD4-CD8- T cell receptor (TCR) alpha beta cytotoxic T lymphocytes (CTL) and their allogeneic tumor rejection were investigated. Inocula of BALBRL male 1 were rejected in C57BL/6 (B6) mice treated with minimum essential medium (MEM) (control), anti-L3T4 (CD4) monoclonal antibody (mAb) or anti-Lyt-2.2 (CD8) mAb and CTL against the tumor were generated in vitro. No rejection and no induction of CTL were observed in B6 mice treated with anti-L3T4 (CD4) plus anti-Lyt-2.2 (CD8) mAb. CTL with the classical Thy-1+ CD3+CD4-CD8+ TCR alpha beta phenotype were generated in mixed lymphocyte tumor cell culture (MLTC) spleen cells from B6 mice treated with MEM (control) or anti-L3T4 (CD4) mAb, whereas CTL with an unusual Thy-1+CD3+CD4-CD8- TCR alpha beta phenotype were generated in MLTC spleen cells from anti-Lyt-2.2 (CD8) mAb-treated B6 mice. Both types of CTL were reactive with both H-2Kd and Dd (Ld) class I antigen. These findings suggest that when CD4+ cells were blocked by anti-L3T4 (CD4) mAb, CD8+ CTL mediated rejection, and when CD8+ cells were blocked by anti-Lyt-2.2 (CD8) mAb, CD4+ cells were capable of mediating rejection, although less efficiently than CD8+ cells, by inducing CD4-CD8- TCR alpha beta CTL. The finding that adoptive transfer of CD4 and CD8-depleted MLTC spleen cells, obtained from anti-Lyt-2.2 (CD8) mAb-treated B6 mice that had rejected BALBRL male 1, resulted in rejection of BALBRL male 1 inoculated into B6 nu/nu mice confirmed the above notion. CTL clones with the CD4-CD8- TCR alpha beta phenotype specific for Ld were established.
Perinatal ECHOvirus Infection: Risk of Transmission during a Community Outbreak
Authors: John F. Modlin, B. Frank Polk, Paula Horton, Paul Etkind, Eileen Crane, Amelia Spiliotes
Journal: New England Journal of Medicine (1981)

During a community outbreak of enterovirus infection, seven of 194 pregnant women (3.6 per cent) were found to be excreting a prime strain of echovirus 11 at term. Each of the seven women possessed serum neutralizing echovirus 11 antibody in titers ranging from 1:20 to 1:320, and the cord serum of their seven infants had antibody in titers of 1:10 to 1:640. None of these seven infants became ill, but four were shedding virus from the respiratory or gastrointestinal tract by three days of age. In a previous study, four infants who died of generalized infection due to the same strain of echovirus 11 had no detectable antibody in cord serum. None of the infants of virus-negative mothers became infected, according to cultures at hospital discharge (151 infants) or at two weeks of age (135 infants). We conclude that passive transplacental acquisition of antibody prevents severe, systemic echovirus disease but does not prevent mucosal infection in the perinatally infected infant.
Endoscopic Teflon injection for a refluxing ureteric stump after simple nephrectomy.
Authors: K N Bullock, A M Deane, M H Ashken
Journal: BMJ (1985)

Endoscopic Teflon injection for a refluxing ureteric stump after simple nephrectomy Persistence of vesicoureteric reflux into adult life is unusual nowadays given the aggressive investigation of childhood urinary tract in- fections.We report a case in which a simple nephrectomy performed for apparent end stage calculous disease of the kidney was complicated by the discovery, postoperatively, that the renal abnormality was due to unrecognised vesicoureteric reflux.
Medical research in antarctica
Authors: V. E. Fuchs
Journal: BMJ (1969)

p. 432) was an excellent testimony to the efficacy of D.C. defibrillation in terminating ventricular fibrillation, it raises an important point.The values for arterial Pco2 quoted show that the patient was adequately " titrated " with, presumably, bicarbonate solutions, but the values quoted for arterial Pco2 are: 107 mm.Hg, 97 mm.Hg, and 107 mm.Hg, respectively.A high Pco2 is known to alter the automaticity of pacemaker cells, and above a value of about 70 mm.Hg may be associated with the production of ectopic beats,' especi- ally in an already abnormal myocardium.A high Pco2 will also cause the release of endo- genous catecholamines,2 which have a similar electrophysiological effect as well as changing the refractory periods and increasing the rate of discharge of pacemaker cells.'Could it be possible that, in the presence of the myocardial infarction, the episodes of ventricular fibrillation were related to the respiratory failure ?Were this the case then surely the appropriate therapy lies in the avoidance of high oxygen-enriched mixtures for the patient to breathe, and, should the hypercapnia persist at unacceptable levels, the institution of mechanical ventilation.-I am, etc.,
Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration
Authors: Julia Esser, Ulf Gehrmann, Fabio Luiz D'Alexandri, Alicia M. Hidalgo-Estévez, Craig E. Wheelock, Annika Scheynius, Susanne Gabrielsson, Olof Rådmark
Journal: Journal of Allergy and Clinical Immunology (2010)
Histological subclassification of cirrhosis using the Laennec fibrosis scoring system correlates with clinical stage and grade of portal hypertension
Authors: Moon Young Kim, Mee Yon Cho, Soon Koo Baik, Hong Jun Park, Hyo Keun Jeon, Chong Kun Im, Chan Sik Won, Jae Woo Kim, Hyun Soo Kim, Sang Ok Kwon, Min Seob Eom, Seung Hwan Cha, Young Ju Kim, Sei Jin Chang, Samuel S. Lee
Journal: Journal of Hepatology (2011)
Compliance therapy: a randomised controlled trial in schizophrenia
Authors: C. O'Donnell
Journal: BMJ (2003)

To evaluate the efficacy of "compliance therapy" for improving adherence to prescribed drug treatment among patients with schizophrenia.Randomised controlled trial.Urban catchment area psychiatric service.94 consecutive admissions of patients with schizophrenia, 56 agreed to participate.Compliance therapy and non-specific counselling, each consisting of 5 sessions lasting 30-60 minutes.Compliance with drug treatment at one year; attitudes to treatment, symptomatology, insight, and quality of life at one year; length of "survival" in the community, bed days, and rehospitalisation rates at two years.Compliance therapy did not confer a major advantage over non-specific therapy in improving compliance at one year (43% (12/28) v 54% (15/28), difference -11% (95% confidence interval -37% to 15%) or in any of the secondary outcome measures-symptomatology, attitudes to treatment, insight, global assessment of functioning, and quality of life.Compliance therapy may not be of benefit to patients with schizophrenia. Attitudes to treatment at baseline predicted adherence one year later and may be a clinically useful tool.
Bone Cells on Microcarrier Spheres
Authors: Guy A. Howard, Russell T. Turner, J. Edward Puzas, Frank Nichols, David J. Baylink
Journal: JAMA (1983)

Many of the experiments being done in our laboratory to gain a clearer understanding of bone metabolism require the use of cell culture techniques to examine the effects of ions or hormones on a specific cell population. Unfortunately, however, because the isolated osteoblasts and their precursors are anchorage-dependent cells, it is often difficult to obtain large numbers of these cells by standard tissue culture techniques. In an attempt to overcome these difficulties and thus obtain large numbers of these cells, we have adapted a technique of using microspheres (Superbeads, Flow Laboratories, or Cytodex 1, Pharmacia) to which cells will attach and proliferate. These microspheres are composed of diethylaminoethyl anion exchange groups bound to a dextran matrix. First discovered by van Wezel,<sup>1</sup>and worked into research scale applications by Levine et al,<sup>2</sup>this method offers all of the advantages of suspension cultures for large-scale cultivation of cells, while providing
Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa.
Authors: A Heeckeren, R Walenga, M W Konstan, T Bonfield, P B Davis, T Ferkol
Journal: Journal of Clinical Investigation (1997)

In cystic fibrosis (CF), defective function of the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells and submucosal glands results in chronic pulmonary infection with Pseudomonas aeruginosa. The pulmonary infection incites an intense host inflammatory response, causing progressive suppurative pulmonary disease. Mouse models of CF, however, fail to develop pulmonary disease spontaneously. We examined the effects of bronchopulmonary infection on mice homozygous for the S489X mutation of the CFTR gene using an animal model of chronic Pseudomonas endobronchial infection. Slurries of sterile agarose beads or beads containing a clinical isolate of mucoid P. aeruginosa were instilled in the right lung of normal or CF mice. The mortality of CF mice inoculated with Pseudomonas-laden beads was significantly higher than that of normal animals: 82% of infected CF mice, but only 23% of normal mice, died within 10 d of infection (P = 0.023). The concentration of inflammatory mediators, including TNF-alpha, murine macrophage inflammatory protein-2, and KC/N51, in bronchoalveolar lavage fluid in CF mice 3 d after infection and before any mortality, was markedly elevated compared with normal mice. This inflammatory response also correlated with weight loss observed in both CF and normal littermates after inoculation. Thus, this model may permit examination of the relationship of bacterial infections, inflammation, and the cellular and genetic defects in CF.
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
Authors: Tobias Goldmann, Peter Wieghofer, Philippe F Müller, Yochai Wolf, Diana Varol, Simon Yona, Stefanie M Brendecke, Katrin Kierdorf, Ori Staszewski, Moumita Datta, Tom Luedde, Mathias Heikenwalder, Steffen Jung, Marco Prinz
Journal: Nature Neuroscience (2013)
Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment
Authors: R SHIBATA, K SATO, M KUMADA, Y IZUMIYA, M SONODA, S KIHARA, N OUCHI, K WALSH
Journal: Cardiovascular Research (2007)

Adiponectin, a circulating adipocyte-derived hormone, exerts beneficial actions on hearts subjected to ischemia-reperfusion injury. Adiponectin exists in plasma as three different oligomeric forms: trimer, hexamer and high molecular weight. This study investigated the expression and myocardial accumulation of adiponectin in a murine model of ischemia-reperfusion injury.Wild-type and adiponectin deficient mice were subjected to left anterior descending artery ligation followed by reperfusion. Plasma adiponectin levels were analyzed by ELISA and adiponectin in heart was determined by immunohistochemical, Western blot and real-time PCR analyses.Plasma adiponectin levels declined after myocardial ischemia-reperfusion injury due to reductions in high molecular weight and, to a lesser extent, trimer and hexamer isoforms. Adiponectin protein was detected in injured but not sham-operated heart, and this was accompanied by a negligible increase in adiponectin transcript in the myocardium. Systemic delivery of adiponectin to adiponectin knockout (APN-KO) mice led to the accumulation of adiponectin in ischemia-reperfusion-injured, but not-uninjured hearts at levels comparable to wild-type suggesting that cardiac expression of adiponectin does not appreciably contribute to its accumulation in the infarcted heart. The serum half-life of adiponectin was 7.4+/-0.3 h in ischemia-reperfusion and 9.7+/-0.5 h in sham-operated mice (P>0.05), whereas the half-life of adiponectin in the damaged heart was 26.9+/-2.2 h (P<0.05).These data show that adiponectin accumulates in the heart following ischemic damage primarily through leakage from the vascular compartment, and that adiponectin has a longer half-life in damaged heart tissue than in plasma.
STUDIES ON THE INCREASE OF VACCINE VIRUS IN CULTURED HUMAN CELLS BY MEANS OF THE FLUORESCENT ANTIBODY TECHNIQUE
Authors: Wilbur Fiske Noyes, Barbara K. Watson
Journal: The Journal of Experimental Medicine (1955)

The specific detection of the antigens of vaccine virus in cultured human cells by means of fluorescent antibody is reported. The antigenic material occurred in the cytoplasm in progressively increasing amounts and in the early stages was in close contact with the nuclear membrane. The antigens were present in a finely particulate form, either as foci or loosely spread out, up to late stages of infection, at which time the staining assumed a homogeneous form due either to close packing of the particles or to soluble antigen, or both. In late stages, homogeneous collections of antigen were observed in the nucleus. They may have resulted from diffusion of soluble antigen through the nuclear membrane. The antigens were observed in situations which suggest a new method of spread from one to another of these cells, namely by transmission through cytoplasmic connections.
Cholescintigraphy in Gallbladder Carcinoma
Authors: PATRICK M. COLLETTI, PHILIP W. RALLS, MICHAEL E. SIEGEL, JAMES M. HALLS
Journal: Clinical Nuclear Medicine (1986)

Findings on cholescintigraphy in gallbladder carcinoma are described in five patients. Four patients presenting with acute cholecystitis had nonvisualization of the gallbladder with normal hepatoenteric transit time. One of these had a large portal mass and two had liver metastasis as additional findings. The fifth patient was jaundiced, and showed absence of bowel activity compatible with total biliary obstruction. Both the clinical and scintigraphic findings in gallbladder carcinoma are difficult to separate from findings in cholelithiasis and cholecystitis.
THE CAUSE OF THE EXCESSIVE CALCIUM EXCRETION THROUGH THE FECES IN INFANTILISM
Authors: F. H. McCrudden, H. L. Fales
Journal: The Journal of Experimental Medicine (1913)

Analyses of the principal known bases and acids of the feces in cases of infantilism in which excessive amounts of calcium are being lost, and comparison with cases which are normal in this respect, show that the fats, fatty acids, and volatile acids are not high, and lead to the conclusion that the loss of calcium is not secondary to the presence of large quantities of phosphates, fatty acids, or volatile acids.
Biotechnology Creating Edible Vaccines
Authors: Cynthia Washam
Journal: Annals of Internal Medicine (1997)

Currents15 September 1997Biotechnology Creating Edible VaccinesCynthia WashamCynthia WashamSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-6-199709150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The technology that first enabled the synthesis of immunoglobulin molecules in tobacco plants is now being used to grow vaccines in fruits and vegetables. Although years from approval, this approach holds promise for people who fear needles and for countries that cannot afford to pay for distribution, storage, and delivery of costly injectable vaccines.Researchers have had the most success cultivating food-borne vaccines against enteric diseases, particularly Escherichia coli and Norwalk virus. Hepatitis B, rabies, rotavirus, and HIV are also being studied for potential vaccine development in produce.In August, the U.S. Food and Drug Administration granted approval to begin ... Author, Article, and Disclosure InformationAuthors: Cynthia WashamAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMolecular Farming for Production of Biopharmaceuticals and Edible Vaccines in PlantsTransgenic Crop Plants: Contributions, Concerns, and CompulsionsNovel foods to treat food allergy and gastrointestinal infectionNovel foods to treat food allergy and gastrointestinal infectionChildren and Genetically Engineered Food: Potentials and Problems 15 September 1997Volume 127, Issue 6Page: 499KeywordsCellsChildrenDiarrheaHIV vaccinesHepatitis BImmune responsePathogensProteinsRabiesVaccines ePublished: 15 August 2000 Issue Published: 15 September 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
"ARSPHENAMIN DERMATITIS, MERCURIAL POISONING AND LEAD INTOXICATION"
Authors: Harry Lutz
Journal: JAMA (1925)

<h3>To the Editor:</h3> —After reading the article of Drs. Charles C. Dennie and William L. McBride (The Journal, Dec. 27, 1924, p. 2082) permit me to warn all readers of some possible misunderstandings. So far as dermatitis exfoliativa is concerned, what is claimed to be sodium thiosulphate in aqueous solution, when given intravenously, seems to be beneficial. In that form of acute arsenic poisoning characterized by glandular destruction and presenting the signs and symptoms that accompany the partial or complete loss of function of the involved organs, permit me to warn all that, even though directions are followed carefully and the so-called aqueous solution of sodium thiosulphate is the drug used, the physician is many times disappointed and the result disastrous. In the chronic forms of arsenic poisoning, I doubt the value of the drug in question very much. As for mercurial poisoning due to the ingestion of mercuric chlorid,
Clinical course and prognostic factors in acute low back pain: an inception cohort study in primary care practice
Authors: J Coste, G Delecoeuillerie, A C. de Lara, J M LeParc, J B Paolaggi
Journal: BMJ (1994)

To describe the natural course of recent acute low back pain in terms of both morbidity (pain, disability) and absenteeism from work and to evaluate the prognostic factors for these outcomes.Inception cohort study.Primary care.103 patients with acute localised non-specific back pain lasting less than 72 hours.Complete recovery (disappearance of both pain and disability) and return to work.90% of patients recovered within two weeks and only two developed chronic low back pain. Only 49 of 100 patients for whom data were available had bed rest and 40% of 75 employed patients lost no time from work. Proportional hazards regression analysis showed that previous chronic episodes of low back pain, initial disability level, initial pain worse when standing, initial pain worse when lying, and compensation status were significantly associated with delayed episode recovery. These factors were also related to absenteeism from work. Absenteeism from work was also influenced by job satisfaction and gender.The recovery rate from acute low back pain was much higher than reported in other studies. Those studies, however, did not investigate groups of patients enrolled shortly after the onset of symptoms and often mixed acute low back pain patients with patients with exacerbations of chronic pain or sciatica. Several sociodemographic and clinical factors were of prognostic value in acute low back pain. Factors which influenced the outcome in terms of episode recovery (mainly physical severity factors) were only partly predictive of absenteeism from work. Time off work and return to work depended more on sociodemographic and job related influences.
Treatment of Heart Disease in the Adult
Authors: Harry B. Greenberg
Journal: JAMA (1968)

For the intern needing immediate information about dosage, method of administration, or even what to do next, this book will prove useful. Theory receives little space, and controversy is limited or altogether omitted. Because of the authors' almost painful efforts to be inclusive, drugs now largely superseded receive considerable attention. But the new and potent diuretics furosemide and ethacrynic acid are mentioned only briefly. On the other hand, sections concerning treatment of myocardial infarction, bacterial endocarditis, and electrolyte disturbances are informative. The uses of digitalis and its analogues are described repeatedly and in detail. Much space is also allotted to the thiazide diuretics for which the authors express some preference. The section on cardiac arrhythmias gives useful information regarding the indications and contraindications for quinidine, diphenylhydantoin sodium (Dilatin), procainamide, lidocaine, and propranolol. The authors also explain techniques for electrical pacemaking and defibrillation. Short descriptions of elective cardioversion briefly set forth
Training and Postgraduate Training in Psychosomatics and Psychotherapy in the Federal Republic of Germany Today
Authors: Heinz Schepank
Journal: Psychotherapy and Psychosomatics (1990)

The training of medical and psychological students at the universities is completely separated. The postgraduate training to become a psychosomaticist, psychotherapist, or psychoanalyst again joins the colleagues of the two branches separated since Descartes and W. Wundt. The curricula and the quantitative result, i.e. the numbers of physicians and psychologists in the FRG, will be described here.
The Writing on the Wall
Authors: Brian M. Wolpin, Peter F. Weller, Joel T. Katz, Bruce D. Levy, Joseph Loscalzo
Journal: New England Journal of Medicine (2009)

A 52-year-old man presented to the emergency department with a 5-week history of abdominal discomfort. The pain worsened after eating and was associated with nausea and bloating. Two weeks before presentation, the patient's pain localized more to the periumbilical area and was accompanied by early satiety and vomiting. He had no fever, diarrhea, tenesmus, melena, or hematochezia.