tbuckley/cabot-search huggingface dataset:
Off-Label Use of Drug-Eluting Stents—Reply
Authors: Nirat Beohar, Charles J. Davidson, Kevin E. Kip, Helen A. Vlachos, David O. Williams
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Playing God—Revisited
Authors: Daniel C. Citron
Journal: Annals of Internal Medicine (1992)

Letters15 June 1992Playing God—RevisitedDaniel C. Citron, MDDaniel C. Citron, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-12-1035 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Dr. LaCombe's captivating story (1) is a stark reminder of the primary role of the physician in 1992 or in any era. Despite expenditure of billions of dollars on health care and despite a burgeoning (often self-serving) medical industrial complex, the primary care physician, whose duty is to relieve pain and suffering, remains that link to humanity, indeed, to the individual.With the onslaught of the acquired immunodeficiency syndrome, the resurgence of tuberculosis and cholera as well as current levels of violence, most of us, even those who treat the most fortunate, still primarily serve to comfort...Reference1. LaCombe M. Playing God. Ann Intern Med. 1992;116:161-2. LinkGoogle Scholar1. LaCombe M. Playing God. Ann Intern Med. 1992;116:161-2. LinkGoogle Scholar2. Shakespeare W. In: Clarke MC; ed. Best Loved Plays of William Shakespeare: Merchant of Venice. The Spencer Press; 1936. Google Scholar1. LaCombe M. Playing God. Ann Intern Med. 1992;116:161-2. LinkGoogle Scholar1. LaCombe M. Playing God. Ann Intern Med. 1992;116:161-2. LinkGoogle Scholar1. LaCombe M. Playing God. Ann Intern Med. 1992;116:161-2. LinkGoogle Scholar2. Cassel C. Reflections on "Playing God" [Editorial]. Ann Intern Med. 1992;116:163-4. LinkGoogle Scholar1. LaCombe M. Playing God. Ann Intern Med. 1992;116:161-2. LinkGoogle Scholar1. LaCombe M. Playing God. Ann Intern Med. 1992;116:161-2. LinkGoogle Scholar1. LaCombe M. Playing God. Ann Intern Med. 1992;116:161-2. LinkGoogle Scholar2. Cassel C. Reflections on "Playing God" [Editorial]. Ann Intern Med. 1992;116:163-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1992Volume 116, Issue 12_Part_1Page: 1035-1037KeywordsAIDSCholeraHealth carePrimary care physicians Issue Published: 15 June 1992 PDF DownloadLoading ...
Type 2 Diabetes and Risk of Rupture of Saccular Intracranial Aneurysm in Eastern Finland
Authors: Antti E. Lindgren, Mitja I. Kurki, Annamaija Riihinen, Timo Koivisto, Antti Ronkainen, Jaakko Rinne, Juha Hernesniemi, Johan G. Eriksson, Juha E. Jääskeläinen, Mikael von und zu Fraunberg
Journal: Diabetes Care (2013)

Type 2 diabetes is a risk factor for other forms of stroke, but its association with subarachnoid hemorrhage (SAH) from ruptured saccular intracranial aneurysm (sIA) has remained unclear.Kuopio Intracranial Aneurysm Database (www.uef.fi/ns) includes all ruptured and unruptured sIA cases from a defined catchment population in eastern Finland since 1980. We compared the age-adjusted incidences of type 2 diabetes in 1,058 ruptured and 484 unruptured sIA patients during 1994-2008, using the national registry of prescribed medicine purchases.Of the 1,058 ruptured sIA patients, 43% were males and 57% females, with a median age at rupture of 51 and 56 years, respectively. From 1994 to 2008 or until death, 9% had been prescribed antidiabetes medication (ADM) with a median starting age of 58 years for males and 66 years for females. Of the 484 unruptured sIA patients, 44% were males and 56% females, with a median age at the diagnosis of 53 and 55 years, respectively, and 9% had used ADM, with a median starting age of 61 years for males and 66 years for females. The incidence of type 2 diabetes was highest in the age-group 60-70 years, with no significant differences between the ruptured and unruptured sIA patients.Our study suggests that type 2 diabetes does not increase the risk of rupture of sIA, which is by far the most frequent cause of nontraumatic SAH.
Children of Psychiatrists and Other Psychotherapists
Authors: Sara C. Charles
Journal: JAMA (1989)

The author writes at the end of this book that "there is no easy or definitive conclusion to what began as a work of curiosity." This book is, in a sense, a journey that we share with the child of a psychoanalyst and a clinical social worker who, like many other children of psychotherapists, seeks to penetrate the secret world of his parents' work as well as to explore how he himself and others like him have been influenced by that world. His search begins with the question, "Are common features to be found among the children of psychotherapists... that stem from different manners of behaving and understanding behavior?" His initial response is, "There appears that there are." The author, an accomplished writer, is an articulate guide, pointing out both the interesting sights and the rocky terrain of a world that is a source of curiosity not only for the
Basal cell carcinomas of the inner canthus: incidence of incomplete excision according to topographical localization of tumours
Authors: F. Boriani, F. Marconi
Journal: British Journal of Dermatology (2007)

Journal Article Basal cell carcinomas of the inner canthus: incidence of incomplete excision according to topographical localization of tumours Get access F. Boriani, F. Boriani Director: Prof. Giovanni Bocchiotti. Department of Plastic Surgery, Turin University, Turin, Italy Search for other works by this author on: Oxford Academic Google Scholar F. Marconi F. Marconi Director: Prof. Giovanni Bocchiotti. Department of Plastic Surgery, Turin University, Turin, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 6, 1 December 2007, Pages 1301–1302, https://doi.org/10.1111/j.1365-2133.2007.08221.x Published: 01 December 2007
CD95-Ligand on Peripheral Myeloid Cells Activates Syk Kinase to Trigger Their Recruitment to the Inflammatory Site
Authors: Elisabeth Letellier, Sachin Kumar, Ignacio Sancho-Martinez, Stefanie Krauth, Anne Funke-Kaiser, Sabrina Laudenklos, Katrin Konecki, Stefan Klussmann, Nina S. Corsini, Susanne Kleber, Natalia Drost, Andreas Neumann, Matthieu Lévi-Strauss, Benedikt Brors, Norbert Gretz, Lutz Edler, Carmen Fischer, Oliver Hill, Meinolf Thiemann, Bahram Biglari, Saoussen Karray, Ana Martin-Villalba
Journal: Immunity (2010)
Improved Outcomes in Hypertension After Physician Tutorials
Authors: THOMAS S. INUI
Journal: Annals of Internal Medicine (1976)

Physicians working at the General Medical Clinic of the Johns Hopkins Hospital entered into tutorials to improve their effectiveness as managers and educators of patients with essential hypertension. After exposure to a single teaching session, tutored physicians allocated a greater percent of clinic-visit time to patient teaching than did control physicians, achieving increased patient knowledge and more appropriate patient beliefs regarding hypertension and its therapy. Patients of tutored physicians were more compliant with drug regimens and had better control of blood pressure than patients of untutored physicians. The personal physician, if he is provided with strategies for identifying the noncompliant patient and for intervening in that behavior, can apply a stimulus to his patients that results in improved compliance and better control of hypertension.
Patients who are eligible but not randomised should be included as additional comparative arm in study
Authors: L P. Fielding, R. Grace, R. Hittinger
Journal: BMJ (1999)

EDITOR—Peto and Baigent state that we need to find ways of making trials much simpler and larger.1 We agree and have a suggestion based on 20 years' experience.2

Everyone is familiar with inclusion and exclusion criteria for randomised controlled trials. With rare exceptions, however, those patients who are eligible but not randomised are a forgotten part of the population; this presents a potentially large problem for all trials. The principal investigators of randomised controlled trials often find that the number of patients …
Letter: Lavatory doors.
Authors: M D Begley
Journal: BMJ (1973)

study" listed by Short et al.3 is that of gastric acidity in patients with Siogren's syndrome.Furthermore, they have reviewed the question of gastric acidity in rheumatoid arthritis,3 particularly wit,h reference to Edstrom's studies.2The latter author found achlorhydria among 12-8% of patients with rheumatoid arthritis under 40 and 28-6% of those over 40, a higher incidence than in comparable control groups.Short et al. con- firmed these findings for the under 40 age group.While it may be questionable whether the data as presented by these workers can be subjected to proper statistical analysis the studies clearly deserve mention.Together with the point about Sjogren's syndrome they imply that studies of acid secretion should be done before implicating other factors- for example, anti-inflam,matory drugs-as a cause of hypergastrinaemia.-Iam, etc.,
The effectiveness of acne treatment: an assessment by patients of the outcome of therapy
Authors: J.N. NEWTON, E. MALLON, A. KLASSEN, T.J. RYAN, A.Y. FINLAY
Journal: British Journal of Dermatology (1997)

Journal Article The effectiveness of acne treatment: an assessment by patients of the outcome of therapy Get access J.N. NEWTON, J.N. NEWTON Unit of Health‐Care Epidemiology, University of Oxford, Old Road, Headington, Oxford, U.K. Dr J.N. Newton, Unit of Health‐Care Epidemiology, University of Oxford, Old Road, Headington, Oxford OX3 7LF. Search for other works by this author on: Oxford Academic Google Scholar E. MALLON, E. MALLON Department of Dermatology, Churchill Hospital, Headington, Oxford, U.K. Search for other works by this author on: Oxford Academic Google Scholar A. KLASSEN, A. KLASSEN Health Services Research Unit, University of Oxford, Radcliffe Infirmary, Oxford, U.K. Search for other works by this author on: Oxford Academic Google Scholar T.J. RYAN, T.J. RYAN Department of Dermatology, Churchill Hospital, Headington, Oxford, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.Y. FINLAY A.Y. FINLAY Department of Dermatology, University of Wales College of Medicine, Heath Park, Cardiff, Wales Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 4, 1 October 1997, Pages 563–567, https://doi.org/10.1111/j.1365-2133.1997.tb03787.x Published: 01 October 1997 Article history Accepted: 16 May 1997 Published: 01 October 1997
THE REPORT OF THE ROYAL COMMISSION IN REFERENCE TO MEDICAL TEACHING IN LONDON
Authors: E. H. Starling
Journal: BMJ (1913)

REGRET lhas been expressed that there was among the Commissioners a medical man, London graduate, who should be acquainted land witlh the conditions of medical education in an inclusion would, however, have been in to the spirit underlying the appointment mzission.Its labours included the consideration teaching of arts, science, and engineering, of medicine.No teacher of these subjects was included, the Commission being made of administrators and business men (with that is to say, of men whose life business to act or to devise policies after taking the experts on the different problems involved.have been hard, therefore, to make an favouLr of medicine, and still more difficult a representative medical man who, though in the matter,.hadtaken no side in the discussions whichhave occurred during the years of the University.The advantage no suLch man on the Commission is that tlle Com- missioners have come to the burning questions lhave divided medical opinion in London-for example, the concentration of preliminary and early medical studies-with an entirely open mind.they lhave left some of them entirely and have indicated new policies, which may satisfy any particular party in the University, sent, at any rate, an unbiassed attempt to create Medical School which shall be second to none lt behoves everv medical teacher, therefore, approachl the recommendations of the Commission an equally open mind, and to ask hlimself whether, although his pet scheme is not advocated, recommendations may not be, if not in his opinion equally effective, yet a considerable advance on present conditions, and whether they may not contain the possibilities right ddvelopment in the future.The recommendations in the Report fall two lieadings:1.In the first place suggestions are framed which enable the e work ofmicedical education in London with the present machinery, while removing hindrances which medical schools have experienced theeir work.2. In the second place, a plan is seetched out the new University, when it is constituted, establish, either de ntovo or preferably ouit of the present machinery, a University Faculty of Medicine under the thle University and with full control of academic affecting medicine, whichi, whlile preserving vantages of the present English system of miiedical ingg, miay provide, as has never yet been done, carrying out of the other function of a namely, the advancemient of learning.This act creation cannot, however, be immediarte, since awvaits formiiation of a new university by Act of Parliament, in all probability also the voluntary sacrifice on the part of one or more of the present medical It will be convenient, therefore, to deal with the situiation whlich will present itself directly the w ew University is coistituted.
The dangers of disease specific programmes for developing countries
Authors: Roger England
Journal: BMJ (2007)

Last week saw the launch of the new International Health Partnership that Prime Minister Gordon Brown hopes will accelerate progress towards achieving the United Nations' millennium development goals for health (see News doi: 10.1136/bmj.39335.610394.DB). Will the partnership make a difference? Certainly, the joint press releases with Chancellor Merkel of Germany made the right noises (www.number-10.gov.uk/output/Page13047.asp). Politicians are realising, perhaps, that throwing money at countries through disease specific global programmes might make good press, but it is not the way to help Africa.

Although international aid to developing countries for health has doubled to $14bn (£7bn; €10bn) since 2000, much of the increase is tied to individual diseases and is delivered outside of recipient countries' planning and budgeting systems, causing big problems for the recipients. Money for combating HIV and AIDS is the worst. This now exceeds the whole health budget of many of the recipient countries, such as Uganda (figure).⇓ It distorts countries' efforts to deal with their problems, because most of this new aid is delivered “off budget,” resulting in separate plans, operations, and monitoring—all in parallel with government systems. Just as …
Abstract 403: Deletion of HBZ alters lymphomagenesis in HTLV-1 infected humanized SCID mice
Authors: Lindsey Crawford, Prabal Banerjee, Michael Lairmore, Patrick Green, Gerold Feuer
Journal: Cancer Research (2010)

Abstract Human T-lymphotropic virus type 1 (HTLV-1) is the etiologic agent of Adult T-cell Leukemia (ATL), an aggressive, mature CD4+/CD25+ T-cell malignancy. The early molecular events induced by HTLV-1 infection as well as the role of various viral genes in the induction of leukemia remain unclear, predominantly due to the lack of an animal model that recapitulates ATL development. We have previously demonstrated that HTLV-1 is capable of infecting human hematopoietic progenitor and stem cells (CD34+ HPCs). Humanized NOD/SCID (HU-SCID) mice generated by injection with HTLV-1-infected CD34+ HPCs demonstrate persistent infection and reproducibly develop CD4+ T-cell lymphomas (∼80%) with clinical characteristics associated with ATL. The HTLV-1 bZIP protein (HBZ) is consistently expressed in all ATL cells and has been implicated in the maintenance of leukemogenesis. HBZ has previously been demonstrated to modulate Tax activity and to interact with the cellular factors CREB, Jun and p53. Transduction of HBZ into CD34+ HP/HSCs using a lentivirus vector suppresses clonogenic colony formation in vitro. Moreover, infection of CD34+ HP/HSCs with an infectious proviral clone lacking functional HBZ (HTLV-1ΔHBZ) results in elevated clonogenic colony formation in vitro, suggesting that HBZ suppresses hematopoiesis. To establish the role of HBZ in HTLV-1 replication and leukemogenesis in vivo, HU-SCID mice were infected with an infectious proviral clone lacking functional HBZ (HTLV-1ΔHBZ). HTLV-1ΔHBZ-infected HU-SCID mice developed lymphoproliferations that were phenotypically characterized as a mixture of immature lymphoid progenitors (CD90+) and mature B-cells (CD19+) starting at ∼10 weeks post-reconstitution, in contrast to wild-type HTLV-1 infection. Lymphoproliferations induced by HTLV-1ΔHBZ successfully engraft and expand in naïve NOD/SCID mice when injected into the peritoneal cavity and leukemic cells and lymphoma cells express HTLV-1 gp46env and p19gag. FACS-purified CD90+CD19− HTLV-1ΔHBZ infected cells also successfully engraft in naïve NOD/SCID mice and mature into CD19+ cells suggesting that these cells may be leukemic progenitors with the capability of maturing in vivo. In addition, a majority of HTLV-1ΔHBZ-infected HU-SCID mice also develop a progressive, flaccid hind limb paralysis with features similar to the neurological disorder, HAM/TSP. These results suggest that HBZ is dispensable for HTLV-1 replication and modulates lymphomagenesis in the HU-SCID model. The humanized SCID mouse provides a novel in vivo platform for analysis of the role of HTLV-1 genes in viral replication and pathogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 403.
Gene Expression, Synteny, and Local Similarity in Human Noncoding Mutation Rates
Authors: M. T. Webster
Journal: Molecular Biology and Evolution (2004)

The human genome is organized with regard to many features such as isochores, Giemsa bands, clusters of genes with similar expression patterns, and contiguous regions with shared evolutionary histories (synteny blocks). In addition to these genomic features, it is clear that mutation rates also vary across the human genome. To address how mutation rates and genomic features are related, we analyzed substitution rates at three classes of putatively neutral noncoding sites (nongenic, intronic, and ancestral repeats) in ∼14 Mb of human–chimpanzee alignments covering human chromosome 7. Patterns of mutation rate variation inferred from substitution rate variation differ among the three site classes. In particular, we find that intronic mutation rates are strongly affected by the breadth of expression of the genes in which they reside, with broadly expressed genes exhibiting low mutation rates, probably as a consequence of the transcription-coupled repair process acting in the germ line. All site classes show significant local similarities in mutation rate at the megabase scale, and regional similarities in nongenic mutation rate covary with blocks of synteny between the human and mouse genomes, indicating that the evolutionary history of a genomic region is an important determinant of mutation rate.
Caring for the Poor: The Altruism of Physicians
Authors: Kevin C. Kelleher
Journal: JAMA (1989)

To the Editor.—  I just finished reading the well-considered commentary Medical Care for the Poor: No Magic Bullets by Dr Ginzberg. 1 His analysis of current shortcomings in the care of the indigent are, it seems, well researched, and he communicates the feeling that he has grappled with the problem and continues to do so. Though I am certain I have not thought as long or as hard, sometimes a simple opinion from a parochial source is able to shed light.  First, in any consideration of health care planning there is a common major flaw: the altruism of the physicians is not relied on. You may say, How can it be? yet the centuries have demonstrated that the majority of physicians donate significant time and expense caring for the indigent. Here in Roanoke, Va, a free clinic is staffed voluntarily by local physicians, dentists, nurses, and health care workers. We
Endoscopic Sphincterotomy in the Management of Gallstone Pancreatitis
Authors: S. van der Spuy
Journal: Endoscopy (1981)

The presence of pancreatitis does not constitute a contraindication to endoscopic sphincterotomy in the management of common duct calculi. On the contrary, experience with 10 cases of gallstone pancreatitis suggests that endoscopic sphincterotomy can be carried out safely with little disturbance to the patient, and that it greatly simplifies the management of these cases. In the frail and elderly patient little further may be required.
Pregnancy IFN‐γ responses to foetal alloantigens are altered by maternal allergy and gravidity status
Authors: L. A. Breckler, J. Hale, A. Taylor, J. A. Dunstan, C. A. Thornton, S. L. Prescott
Journal: Allergy (2008)

Background: During pregnancy, variations in maternal–foetal cellular interactions may influence immune programming. This study was carried out to determine if maternal responses to foetal alloantigens are altered by maternal allergic disease and/or previous pregnancies. Methods: For this cohort study, peripheral blood was collected from allergic ( n = 69) and nonallergic ( n = 63) pregnant women at 20, 30, 36‐week gestation and 6‐week postpartum (pp). Cord blood was collected at delivery. Mixed lymphocyte reactions were used to measure maternal cytokine responses [interleukin‐6 (IL‐6), IL‐10, IL‐13 and (interferon‐γ) IFN‐γ] at each time point towards foetal mononuclear cells. Results: Maternal cytokine responses during pregnancy (20, 30 and 36 weeks) were suppressed compared to the responses at 6‐week pp. The ratio of maternal IFN‐γ/IL‐13 and IFN‐γ/IL‐10 responses were lower during pregnancy. Allergic mothers had lower IFN‐γ responses at each time‐point during pregnancy with the greatest difference in responses observed at 36‐week gestation. When allergic and nonallergic women were further stratified by gravidity group, IFN‐γ responses of allergic multigravid mothers were significantly lower than nonallergic multigravid mothers during pregnancy. Conclusions: During normal pregnancy, peripheral T‐cell cytokine responses to foetal alloantigens may be altered by both allergic status of the mother and previous pregnancies. These factors could influence the cytokine milieu experienced by the foetus and will be further explored in the development of allergic disease during early life.