tbuckley/cabot-search huggingface dataset:
US hospital loses Catholic designation after performing a lifesaving abortion
Authors: J. H. Tanne
Journal: BMJ (2010)

St Joseph’s Hospital and Medical Center in Phoenix, Arizona, lost its designation as a Catholic hospital in December because it carried out an abortion in November 2009 to save the life of a 27 year old woman with severe pulmonary hypertension.

The woman, the mother of four children, was in the third month of pregnancy. The hospital said her condition was life threatening and decided to end the pregnancy to save her life.

St Joseph’s, with 697 beds, is the largest hospital in Arizona. It is part of the hospital group Catholic Healthcare West and does not receive any funding from the Phoenix diocese.

Bishop Thomas Olmstead, head of the Phoenix diocese, excommunicated Sister Margaret McBride, a nun on the hospital’s ethics committee who agreed to the abortion, and removed …
Correctional Treatment of the Sexual Deviate
Authors: CHARLES E. SMITH
Journal: American Journal of Psychiatry (1968)

Correctional work with sex offenders is complicated by confusing statutory definitions, uncertainties about diagnosis, problems in motivation for treatment, and many other factors. After evaluating these difficulties and the resources available to overcome them, the author concludes that this group of offenders is most effectively treated in a hospital rather than a correctional setting, using the technique of group psychotherapy.
Novartis must face kickback lawsuit over "sham" speaker events
Authors: M. McCarthy
Journal: BMJ (2014)

Novartis Pharmaceuticals Corporation must face a US government lawsuit alleging that the company violated federal anti-kickback laws by sponsoring sham speaking events to boost sales of its drugs, a federal judge ruled on 30 September.

The lawsuit was initially filed in 2011 by Oswald Bilotta, a former Novartis sales representative, under the False Claims Act—an 1863 law that authorizes private individuals to sue federal contractors on the government’s behalf to recover money lost through fraud. The individual who files the suit stands to share 15-25% of the settlement if the claim is won.

The federal government joined the suit in 2013, alleging that the company—a subsidiary of the Switzerland based Novartis AG—had violated the federal Anti-Kickback Statute that makes it illegal to pay people to …
Two Cases of Malignant Disease of the Thyroid Gland
Authors: P. S. Hutchinson
Journal: BMJ (1889)

gredients of "Sicherheit" explosive on Friday, June 28th, but Saturday and Sunday being holidays did not work a full day until Monday, July 1st, and since then worked regularly until the time of attending at the surgery.On Monday evening, July 1st, he began not to feel well, and his wife noticed that he was very blue.Symptom8.-(1)Subjective: Has much headache of a dull and heavy character, chiefly frontal.Feels very short of breath on ex- ertion.Is "muddled in his mind." (2)Objective: Is cyanosed all over.His appearance can only be compared to that of an infant with patent foramen ovale.The cheeks, naturally ruddy, are of deep purple-blue; hands blue except nails, which are of a yellow- white.The pulse is quick and jerky, 99 per minute.Sphygmographic tracing as below.The blood from prick of finger is of a .
Nafcillin-Induced Interstitial Nephritis
Authors: T. W. Bodendorfer
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Acute interstitial nephritis caused by any drug is probably a rare drug reaction. Methicillin sodium is the most commonly reported penicillin derivative associated with nephritis, with more than 100 cases being reported.<sup>1</sup>Reexacerbation (ie, cross sensitivity) with nafcillin, ampicillin, and cephalothin administration has been reported (1973;225: 178; 1974;227:255).<sup>2</sup>Although histological confirmation was not obtained, this is a probable case of nafcillininduced interstitial nephritis. <h3>Report of a Case.—</h3> A 60-year-old man was admitted to the orthopedic unit of Memorial Hospital Medical Center with a painful swollen right knee. He had a 40-year history of hypertension, rheumatoid arthritis, and coronary artery disease, but no renal disease. Therapy with indomethacin, 100 mg/24 hr, and allopurinol, 200 mg/24 hr, was started. Medicationscontinued from before admission included propranolol hydrochloride, 160 mg/24 hr, isosorbide dinitrate, 160 mg/24 hr, and nitroglycerin as needed. On the second day of hospitalization, knee aspirate
Synthetic Human Parathyroid Hormone 1-34 Fragment for Diagnostic Testing
Authors: Lawrence E. Mallette
Journal: Annals of Internal Medicine (1988)

Since bovine parathyroid extract became unavailable for stimulatory testing, the differentiation between hypoparathyroidism and pseudohypoparathyroidism has been made from the measurement of serum parathyroid hormone (PTH) values alone. Responsiveness to PTH can once again be tested with teriparatide acetate, the newly available, biologically active 1-34 fragment of human PTH. The PTH infusion test can be used to confirm a preliminary diagnosis based on serum immunoreactive PTH values, to differentiate between type 1 and type 2 pseudohypoparathyroidism, or to detect a subtle abnormality of calcium metabolism in normocalcemic patients with features suggesting pseudohypoparathyroidism. Of several variables used to express changes in renal metabolism of cyclic adenosine 3′,5′-monophosphate (cAMP) or phosphate, the 30-minute change in cAMP excretion per unit of glomerular filtration and the 60-minute percentage fall in the tubular maximum for phosphate reabsorption provide the best discrimination. Teriparatide has a low incidence of adverse reactions and provides an effective diagnostic tool.
How much does Disease Activity Score in 28 joints ESR and CRP calculations underestimate disease activity compared with the Simplified Disease Activity Index?
Authors: Roy Fleischmann, Désirée van der Heijde, Andrew S Koenig, Ronald Pedersen, Annette Szumski, Lisa Marshall, Eustratios Bananis
Journal: Annals of the Rheumatic Diseases (2014)

Objectives Disease Activity Score in 28 joints calculated with C-reactive protein (DAS28-CRP) is used instead of erythrocyte sedimentation rate (DAS28-ESR) to assess rheumatoid arthritis disease activity; however, values for remission and low disease activity (LDA) for DAS28-CRP have not been validated. American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) guidelines suggest remission should be calculated by Simplified Disease Activity Index (SDAI) rather than DAS28-ESR. We examined values of remission and LDA of DAS28-CRP that correspond to the respective cut-off points for DAS28-ESR and SDAI from five clinical trials. Methods DAS28-CRP cut-offs that best correspond to DAS28-ESR remission &lt;2.6 and LDA ≤3.2 were obtained by cumulative distribution plots, receiver operating curves and maximum concordance and averaged for each approach, treatment group and study. Level of agreement between DAS28-CRP and DAS28-ESR remission and LDA cut-offs was compared against each other and versus SDAI remission ≤3.3 and LDA ≤11. Results Percentage of patients who achieved remission and LDA by DAS28-ESR cut-offs was greater for DAS28-CRP versus DAS28-ESR regardless of patient population or treatment group. Discordance between CRP and ESR cut-offs ranged from 4%–26% and 8%–23% for remission and LDA, respectively, and 19%–40% and 6%–11% for DAS28-CRP versus SDAI, respectively. Estimated (range) remission and LDA thresholds were 2.4 (2.2–2.6) and 2.9 (2.6–3.3), 1.9 (1.6–2.2) and 3.1 (3.1–3.3) and 2.2 (1.1–2.9) and 3.6 (3.4–4.0) for DAS28-CRP versus DAS28-ESR, DAS28-CRP versus SDAI and DAS28-ESR versus SDAI, respectively. Conclusions DAS28-CRP underestimates disease activity when using cut-off points validated for DAS28-ESR; therefore, DAS28-ESR cut-off values should not be applied to DAS28-CRP. Although DAS28-CRP and DAS28-ESR cut-offs for LDA ≤3.2 correspond to SDAI LDA, neither corresponds well to SDAI remission.
Managing Older Patients With Colorectal Cancer
Authors: Hanna Kelly Sanoff, Harry Bleiberg, Richard M. Goldberg
Journal: Journal of Clinical Oncology (2007)

Colorectal cancer (CRC) is predominantly a disease of older persons, and our population is aging. Physicians and their older patients commonly face the dilemma of whether or not to give/receive systemic chemotherapy for CRC. Evidence supports the safety and efficacy of systemic chemotherapy in fit older patients motivated enough to enroll onto clinical trials. Conversely, frail older patients are more likely to suffer adverse outcomes when faced with stressors and may not benefit from chemotherapy. However, the majority of patients are neither fit nor frail, and current evidence is insufficient to either quantify or qualify the benefit of chemotherapy for this intermediate group of patients. Thus, treatment decisions must be individualized based on each older person's physical state (eg, their function and degree of comorbidity) and values. Despite a growing body of data, a great deal of work is still needed to establish optimal strategies to care for patients diagnosed with cancer later in life.
Ode to Dry Hands
Authors: Adam Possner
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Changing Epidemiology of Invasive Group A Streptococcal Infections and the Emergence of Streptococcal Toxic Shock-like Syndrome
Authors: Charles W. Hoge
Journal: JAMA (1993)

To determine disease incidence and changes in the epidemiology of invasive group A streptococcal infections in a community in Arizona.We retrospectively surveyed microbiology records from all 10 hospitals in Pima County, Arizona, to identify patients who had Streptococcus pyogenes isolated from blood, sterile body fluid, or tissue biopsy specimens between April 1985 and March 1990. Demographic and clinical information was abstracted from the medical records of these patients.A total of 128 patients with a median age of 53.5 years (range, 6 months to 96 years).Racial/ethnic differences in disease incidence; mortality and changes in the clinical spectrum of disease over the study period.The annual age-adjusted incidence was 4.3 per 100,000 but was 46.0 per 100,000 among Native Americans. Advanced age, age less than 5 years, hypotension, and multi-organ system involvement were significantly associated with increased mortality. From 1985 to 1990, the proportion of infections with hypotension, rash, desquamation, renal impairment, and gastrointestinal involvement increased significantly (chi 2 for trend P < or = .02 for each feature). A toxic shock-like syndrome occurred in 8% of infections since 1988, compared with none of the infections between 1985 and 1987 (P = .04). Patients with the syndrome were younger than patients with other invasive infections (median age 15 vs 54 years, P = .02), and were less likely to have underlying medical conditions (P = .008).Significant changes occurred in the spectrum of invasive group A streptococcal infections in Pima County, Arizona, between 1985 and 1990. Native Americans were at increased risk of acquiring these infections. Patients with the streptococcal toxic shock-like syndrome had epidemiologic features that distinguished them from patients with other invasive infections, including younger age and less underlying illness.
A Modest Institution With Grand Designs
Authors: Timothy F. Kirn
Journal: JAMA (1988)

THE SPONSOR OF the Growing Healthy curriculum, the National Center for Health Education, has itself never really been healthy. At least, the center has never achieved the preeminence or the proportions originally envisioned when it was established. The center came into being in about 1975, the result of a recommendation from former President Richard Nixon's President's Committee on Health Education. At its suggestion, support for the center was to come from both the government and private sources, along the lines of the Institute of Medicine in Washington, DC. The center was to function in part as an umbrella, connecting and coordinating the disparate activities of the various organizations working in health education. But the funding to foster its development never materialized, says M. Roy Schwarz, MD, assistant executive vice president of the American Medical Association and the and the center's current board chair. "I can say we've done things right,"
The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells
Authors: Jen-Liang Su, Pan-Chyr Yang, Jin-Yuan Shih, Ching-Yao Yang, Lin-Hung Wei, Chang-Yao Hsieh, Chia-Hung Chou, Yung-Ming Jeng, Ming-Yang Wang, King-Jen Chang, Mien-Chie Hung, Min-Liang Kuo
Journal: Cancer Cell (2006)
Tropoelastin Gene Expression in Individual Vascular Smooth Muscle Cells
Authors: James K. Belknap, Nicole A. Grieshaber, Phillip E. Schwartz, E. Christopher Orton, Michael A. Reidy, Richard A. Majack
Journal: Circulation Research (1996)

Abstract After vascular injury, quiescent adult smooth muscle cells (SMCs) revert to a more immature synthetic-state phenotype concomitant with the onset of cell replication. The relationship between SMC proliferation and the reexpression of genes characteristic of immature SMCs (eg, tropoelastin [TE]), on an individual cell basis, has not been determined. Using a combined bromodeoxyuridine (BrdU) immunocytochemistry–TE in situ hybridization technique, we determined the relationship between DNA synthesis and TE gene expression in the rat vascular wall during development and after experimental injury. During the early development of the aortic media (embryonic days 13 to 18), low but detectable levels of TE expression occurred equally in both replicating and nonreplicating SMCs. TE message levels dramatically increased in the late fetal and early postnatal periods (fetal day 19 to 1 month postpartum), after a precipitous drop in SMC replication, and then decreased to undetectable levels by postpartum day 60. After balloon catheter injury in the adult, a developmental sequence of SMC replication followed by TE gene expression was reiterated in both the media and in the developing neointima. On an individual cell basis, adult SMCs replicating after injury expressed little or no TE message; detectable TE gene expression occurred only in nonreplicating SMCs. The most important implications of these data are that (1) adult SMCs replicating after injury appear to revert to a preelastogenic embryonic phenotype; (2) maximal TE expression occurs in SMCs only after the cessation of cell replication; and (3) in both the media and the neointima, adult SMCs responding to injury undergo temporally sequential changes in phenotype reflective of SMC development.
Comparative Genomics and Evolution of Proteins Associated with RNA Polymerase II C-Terminal Domain
Authors: Zhenhua Guo, John W. Stiller
Journal: Molecular Biology and Evolution (2005)

The C-terminal domain (CTD) of the largest subunit of RNA polymerase II provides an anchoring point for a wide variety of proteins involved in mRNA synthesis and processing. Most of what is known about CTD-protein interactions comes from animal and yeast models. The consensus sequence and repetitive structure of the CTD is conserved strongly across a wide range of organisms, implying that the same is true of many of its known functions. In some eukaryotic groups, however, the CTD has been allowed to degenerate, suggesting a comparable lack of essential protein interactions. To date, there has been no comprehensive examination of CTD-related proteins across the eukaryotic domain to determine which of its identified functions are correlated with strong stabilizing selection on CTD structure. Here we report a comparative investigation of genes encoding 50 CTD-associated proteins, identifying putative homologs from 12 completed or nearly completed eukaryotic genomes. The presence of a canonical CTD generally is correlated with the apparent presence and conservation of its known protein partners; however, no clear set of interactions emerges that is invariably linked to conservation of the CTD. General rates of evolution, phylogenetic patterns, and the conservation of modeled tertiary structure of capping enzyme guanylyltransferase (Cgt1) indicate a pattern of coevolution of components of a transcription factory organized around the CTD, presumably driven by common functional constraints. These constraints complicate efforts to determine orthologous gene relationships and can mislead phylogenetic and informatic algorithms.
THE TREATMENT OF TUBERCULOUS DISEASES: THE EFFICACY OF SODIUM MORRHUATE INJECTIONS COMPARED WITH OTHER TREATMENTS
Authors: P. W. R. Boelke
Journal: BMJ (1923)

TREATMENT OF TUBERCULOUS DISEASES.r MTDBsJ 124g appear to err on the liberal side, but the guardians, rightly or wrongly, hold the view that relief should be adequate to the needs of the applicant, and particularly in the case of children, who, well fed rather than half-starved, are much less likely later on to fall victims to sickness and be thrown again on local rates.This surely is an enlightened policy which is followed by the borough council in supplyinig dried milk free under a liberal wage scale to nursing imiothers and young children, as well as by generous provision of con- valescent treatment for ailing youth.Carping critics allege that relief schemes foster indifference and mendicancv.It miiay be so in isolated cases, and occasionially one meets with whlat at first sight appears to justify the criticism.For instance, my chief clerk, crossing the hall corridor, met a little vulgar boy." Well, my little man, what do you wanit?" said he. "Please, sir, mother says will you put on a piece of paper what's given away?'"His mnother's request was not granted, but I fancy assistance followed investigation, and those who practically deal with relief know that the black sheep in every flock are few.
Mortality From Pneumonia and Hip Fractures in Patients With Advanced Dementia
Authors: Leopold Liss
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
512. The Cellular TATA-Binding Protein Is Required for Replication of a Minimal Adeno-Associated Virus Type 2 (AAV-2) p5 Promoter Element
Authors: Achille François, Mickael Guilbaud, Rafi Awedikian, Gilliane Chadeuf, Philippe Moullier, Anna Salvetti
Journal: Molecular Therapy (2005)

It was previously reported that the p5 promoter region (nt 191 to 350 of wt AAV-2) of the AAV-2 rep gene contained a cis-acting element that behaved as a Rep-dependent origin of replication in the absence of ITR (Nony et al, J. Virol. 2001; Musatov et al., J. Virol. 2002). This region was also shown to promote AAV-2 site-specific integration into human chromosome 19 (Philpott et al., PNAS 2002). The present study was conducted to identify the minimal elements in the p5 region necessary for the Rep-dependent replication.
Interaction between the insulin-like growth factor family and the integrin receptor family in tissue repair processes. Evidence in a rabbit ear dermal ulcer model.
Authors: R D Galiano, L L Zhao, D R Clemmons, S I Roth, X Lin, T A Mustoe
Journal: Journal of Clinical Investigation (1996)

We have determined previously that IGF-I is dependent on the presence of IGF binding protein-1 (IGFBP-1) to act as a wound healing agent. We sought to determine the mechanism whereby IGFBP-1 is able to enhance IGF-I bioactivity. As IGFBP-1 binds both the alpha5beta1 integrin as well as IGF-I in vitro, we asked which of the following interactions were important: (a) the ability of IGFBP-1 to interact with an integrin receptor, and/or (b) the binding of IGF-I by IGFBP-1. We used an IGF-1 analogue (des(1-3)IGF-I) with a > 100-fold reduction in affinity for IGFBP-1 as well as an IGFBP-1 mutant (WGD-IGFBP-1) which does not associate with the alpha5beta1 integrin to selectively abrogate each of these interactions. We also tested the ability of IGFBP-2, a related binding protein which has an arginine-glycine-aspartate sequence but does not associate with integrin family members, to enhance IGF-I bioactivity. Full-thickness dermal wounds were created on rabbit ears; various combinations of native IGF-I, native IGFBP-1, native IGFBP-2, and their respective analogues/mutants were applied to each wound. Wounds were harvested 7 d later for analysis. Only native IGF-I in combination with native IGFBP-1 was effective as a wound healing agent, enhancing reepithelialization and granulation tissue deposition by 64+/-5 and 83+/-12% over controls (P = 0.008 and 0.016, respectively). The same doses of IGF-I/WGD-IGFBP-1, des(1-3)IGF-I/IGFBP-1, and IGF-I/IGFBP-2 were ineffective. We propose that IGF-I physically interacts with IGFBP-1 and that IGFBP-1 also binds to an integrin receptor, most likely the alpha5beta1 integrin. This interaction is unique to IGFBP-1 as the closely related IGFBP-2 had no effect, a finding consistent with its inability to bind to integrin receptors. Our results suggest that activation of both the IGF-I receptor and the alpha5beta1 integrin is required for IGF-I to stimulate wound healing.
Eradication of diffuse gastric Peutz–Jeghers polyps by unsedated transnasal snare polypectomy and argon plasma coagulation
Authors: J. Lin, M. Chen, W. Lei, W. Law, C. Hu
Journal: Endoscopy (2009)

Peutz–Jeghers syndrome (PJS) is a rare, autosomal dominant disease characterized by hamartomatous gastrointestinal polyps, mucocutaneous pigmentation, and family history of PJS [1]. Rarely, solitary Peutz–Jeghers polyps occur, without other features of PJS, and are associated with an increased risk of gastrointestinal and gynecological cancers. Transnasal ultrathin esophagogastroduodenoscopy (EGD) has an important role in the diagnosis and treatment of Peutz–Jeghers polyps because it is highly tolerable and is also safer than peroral EGD [2] [3].