tbuckley/cabot-search huggingface dataset:
Acute Myocardial Infarction: The Influence of a Coronary Care Unit.
Authors: Robert M. Marshall
Journal: Annals of Internal Medicine (1968)

s1 May 1968Acute Myocardial Infarction: The Influence of a Coronary Care Unit.Robert M. Marshall, M.D., Edward Genton, M.D. (Associate)Robert M. Marshall, M.D.Search for more papers by this author, Edward Genton, M.D. (Associate)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1158_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInfluence of a coronary care unit on the course of patients with acute myocardial infarction was studied. Comparison was made between 87 patients admitted to a coronary care unit and monitored for 1 week at the Colorado General Hospital and 95 patients admitted to medical wards at Denver Veterans Administration Hospital where no coronary care unit facility exists. Both groups included consecutive patients admitted during the same 15 months, from the same geographical area, and cared for by the same rotating physicians. They were similar in age, past history of angina, admission clinical characteristics, and electrocardiographic location of infarction. Arrhythmias... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert M. Marshall, M.D.; Edward Genton, M.D. (Associate)Affiliations: Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5 Page: 1158-1159 Keywords Acute myocardial infarction Angina Arrhythmia Cardiac care unit Electrocardiography Hospitals Infarction ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Mycobacterium chelonae infection resistant to clarithromycin in a patient with dermatomyositis
Authors: J. Bañuls, R. Ramón, E. Pascual, J. Navas, I. Betlloch, R. Botella
Journal: British Journal of Dermatology (2000)

Journal Article Mycobacterium chelonae infection resistant to clarithromycin in a patient with dermatomyositis Get access J. Bañuls, J. Bañuls Services of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar R. Ramón, R. Ramón Services of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar E. Pascual, E. Pascual Rheumatology, Hospital General de Alicante, C/Maestro Alonso 109 03010 Alicante, Spain Search for other works by this author on: Oxford Academic Google Scholar J. Navas, J. Navas Services of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar I. Betlloch, I. Betlloch Services of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar R. Botella R. Botella Services of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 6, 1 December 2000, Page 1345, https://doi.org/10.1046/j.1365-2133.2000.03931.x Published: 01 December 2000
Children's surgery services under threat from competition, says report
Authors: Zosia Kmietowicz
Journal: BMJ (2007)

Children's surgical services could disappear from district general hospitals if they are not exempt from health policies involving competition, forcing children to travel to large specialist centres for routine operations, experts warn.

A report from the Children's Surgical Forum has called for routine surgery for children to remain available locally in the future and not be threatened by initiatives that have introduced competition between trusts.

David Jones, chairman of the Royal College of Surgeons of England and chairman of the forum, …
Surgery for the Ruptured Abdominal Aortic Aneurysm
Authors: Joseph Alpert
Journal: JAMA (1970)

In an eight-year interval, 40 consecutive ruptured abdominal aortic aneurysms were surgically resected in a community hospital. The resulting 43% mortality (18 patients) compares favorably with those reported from the larger university hospitals. A review of cases suggests that a successful surgical outcome depends on many variable factors, but speed in diagnosis and operation still remain the mainstays of success. Since a survival rate of 98% for elective aneurysm resection was obtained in 100 patients during the same eight-year period, we proposed a diligent search for all asymptomatic aneurysms and elective resection.
Suggested merger of mental and neurological illnesses is premature
Authors: S. Bailey, W. Burn, N. Craddock, L. Mynors-Wallis, P. Tyrer
Journal: BMJ (2012)

White and colleagues’ suggestion that the distinction between mental and neurological illnesses should disappear is premature.1 It is perfectly reasonable to argue that mental illnesses are brain diseases—this was clearly stated more than 150 years ago2—but this is not a reason to combine mental and behavioural disorders …
End of the Oldest Controversy in Medicine — Are We Ready to Conclude the Debate on Digitalis?
Authors: Milton Packer
Journal: New England Journal of Medicine (1997)

The role of digitalis in treating cardiovascular disease has been at the center of the oldest continuing controversy in the history of medicine. Ever since its clinical introduction by William Withering more than 200 years ago,1 physicians have disagreed fiercely about the drug's efficacy and safety, with some advocating its widespread use and others recommending that its application be severely limited or abandoned entirely. Evidence from clinical studies published during the past decade has heightened the sophistication of the debate, but not diminished its intensity.Advocates of digitalis have argued that the drug should be used because it has been . . .
CAPILLARY BLOOD PRESSURE IN MAN. COMPARISON OF DIRECT AND INDIRECT METHODS OF MEASUREMENT. 1
Authors: L. W. Eichna, James Bordley
Journal: Journal of Clinical Investigation (1939)

In the course of studies of the peripheral cir- culation in hypertensive subjects it became de- sirable to make measurements of the capillary blood pressure.Previous studies by others (1, 2, 3) had indicated that the capillary blood pres- sure is at approximately the same level in normal and hypertensive subjects.The accuracy of the indirect methods of measurement employed in these earlier studies has never been actually estab- lished.Indeed there is reason to suspect their reliability (4).It seemed necessary, therefore, before attempting to determine capillary blood pressure in hypertensive subjects, to analyze critically some of the available methods of meas- urement, in order to select one which would yield trustworthy results.Two methods were chosen for analysis: (1) the direct microinjection method of Landis (5), and (2) the indirect, pressure- capsule method of Danzer and Hooker (6).Heretofore, no attempt has been made to com- pare in the same individual the results obtained by the direct and indirect methods.The present investigation has led to the conclusion that the two methods do not give comparable results, and that, of the two, only the direct method gives accurate readings. METHODSBecause of their size, accessibility and position parallel to the skin surface, the capillaries in the nail -folds are, in man, the most suitable for blood pressure determina- tions.All of the following observations were made upon capillaries in the nail folds of the fingers of quiet, re- cumbent subjects with normal systemic venous pressures.The capillary bed was always at the level of the heart, i.e., 2 to 5 cm.below the level of the anterior chest wall at the third intercostal space.The observations were made in a quiet, warm room, the temperature of which was usually 240 to 260 C. In none of the experiments was the room temperature higher than 28°C.or lower than 220 C. Digital skin temperature varied from sub- ' Supported by a grant from The Commonwealth Fund for the study of essential hypertension.ject to subject but was fairly constant in any single experiment.The temperature of the finger tip was usu- ally between 280 and 310 C., and always between 250 and 330 C.
Book Review The Medicalization of Cyberspace By Andy Miah and Emma Rich. 160 pp. New York, Routledge, 2008. $140 (cloth); $43.95 (paper). 978-0-415-37622-8 (cloth); 978-0-415-39364-5 (paper).
Authors: Edward W. Campion
Journal: New England Journal of Medicine (2008)
A Note on some Cases Mistaken for Small-Pox During the Recent Epidemic
Authors: C. Fraser
Journal: BMJ (1902)

ature, the subsultus tendinum, the curled-up posture as he lay in bed like a ball of wool, the ensuing paralysis, irregular breathing, deepening coma, and then the end.These were all but a common variety of symptoms of this disease.I quote the case mainly to show how all these symptoms may be ushered in by initial attacks of an aphasic nature.I re- gret that in this case a necropsy was absolutely denied me and that I had to rest content with the history above set forth.We may, however, form a fair estimate of the lesion in this case and in doing so, a summary of the other two cases I have referred to may prove of interest.CASE ii (Schutz).-Aphasiaas an Initial Symptom of Tuber- culous Meningitis.-F.W. Elsner2 gives the following sum- mary of this case, which was apparently believed to be the only example of the kind recorded up till that date.
TECHNICAL CONSIDERATIONS IN GATED BLOOD POOL SPECT
Authors: M. W. Grocly, E. M. Leidholdt, R. C. Marshall, D. J. Schippcrs, W. D. Erwin
Journal: Clinical Nuclear Medicine (1991)

Grocly, M. W.; Leidholdt, E. M.; Marshall, R. C.; Schippcrs, D. J.; Erwin, W. D. Author Information
A differential inotropic responsiveness to isoprenaline and ouabain in dogs with heart failure
Authors: W. H NEWMAN, J. G WEBB
Journal: Cardiovascular Research (1980)

We have previously shown that volume overload heart failure is associated with a depressed inotropic response to isoprenaline, noradrenaline, glucagon, and calcium. In these present experiments, the inotropic response of the failing heart to ouabain was examined because ouabain has a mechanism of action that is different from these other agents. The studies were conducted in dogs with heart failure resulting from an aortocaval fistula. The principal finding was that during heart failure the inotropic response to isoprenaline was markedly depressed while the inotropic response to ouabain was unaltered. These findings, coupled with our previous observations, suggest that heart failure is not associated with some common defect in the excitation-contraction coupling mechanism that reduces the response to inotropic agents. Additionally, we made the first measurements of plasma noradrenaline levels in this model of heart failure and found them to be elevated four-fold.
Association Between Cigarette Smoking and Metabolic Syndrome: Response to Masulli and Vaccaro
Authors: Sang Woo Oh, Taiwoo Yoo
Journal: Diabetes Care (2006)

We thank Massulli and Vaccaro (1) for their interest and comments regarding our article (2). Moreover, we are pleased to hear that they found results similar to ours in a population-based study of Italian men. They reported that, like Korean smokers, Italian smokers had higher triglycerides and lower HDL cholesterol levels than those who had never smoked. They also showed that smoking is …
CHEMICAL CHANGES IN THE BLOOD OF THE DOG IN EXPERIMENTAL PERITONITIS
Authors: Thomas G. Orr, Russell L. Haden
Journal: The Journal of Experimental Medicine (1928)

1. A study of the blood chlorides, urea and non-protein nitrogen and the carbon dioxide-combining power in experimental general peritonitis is here reported. 2. The similarity between the chemical changes in high intestinal obstruction and general peritonitis is noted. These chemical changes suggest that the cause of death may be, at least in part, the same in the two diseases.
An Aid to the Diagnosis of Appendicitis.
Authors: Leonidas Ki[ill]by
Journal: JAMA (1902)

<sub>Harrison, Ark.</sub>, Aug. 23, 1902. <h3>To the Editor:</h3> —After examining a patient with most of the ordinary objective and subjective symptoms of appendicitis— tumefaction, muscular rigidity, fever, pain and cutaneous hyperesthesia—the physician is often still in doubt whether the case is or is not one of appendicitis. In just such cases, indeed in all cases, for the last two years I have learned to depend very materially on the following plan to aid in the diagnosis: Have the patient lie on the back, with the legs flexed on the thighs, the thighs flexed, the feet resting evenly on the bed, the lower limbs held or steadied in this position by an assistant. Then place the tip of one finger on the skin of the abdomen over the seat of greatest tenderness—usually McBurney's point—press down slowly with about as much force as the patient will tolerate. Still keep up this pressure
Too much mammography
Authors: M. Kalager, H.-O. Adami, M. Bretthauer
Journal: BMJ (2014)

Long term follow-up does not support screening women under 60

Before being widely implemented, mammography screening was tested in randomised controlled trials in the 1960s to 80s. Meta-analyses of these trials showed a relative reduction in deaths from breast cancer of between 15% and 25% among women aged 50 to 69.1 2 3 Only the Canadian National Breast Screening Study showed no reduction in breast cancer mortality.1 2 3 This large randomised controlled trial compared physical breast examination with combined physical breast examination and annual mammography in women aged 40 to 59.1 2 3

In a linked paper (doi:10.1136/bmj.g366), Miller and colleagues present the results for up to 25 years of follow-up in the Canadian study.4 No difference in breast cancer mortality was observed between the mammography and control arms, whereas a significant excess incidence of invasive breast cancer was observed in the mammography arm, resulting in 22% overdiagnosis. This means that 22% of screen detected invasive cancers would not have reduced a woman’s life expectancy if left undetected.

The major strengths of this study include its randomised design, intense intervention with …
Psychopharmacology: The Fourth Generation of Progress
Authors: James J. Brophy
Journal: JAMA (1995)

The number 2002 has various connotations in our current thinking: the year of a balanced budget and Medicare bankruptcy. But in the realm of psychopharmacology, 2002 is the number of pages in the latest edition of this definitive book on the subject. At 11 lbs it is a behemoth, but the material therein is an argosy of medical information. It is a major advance over the very good previous edition,<i>Psychopharmacology: The Third Generation of Progress</i>, reviewed in<i>JAMA</i>(1988;259:1392). The 317 contributors from around the world include the best and the brightest minds from the fields of academic and commercial psychopharmacology. Of the 163 chapters, approximately one third deal with the preclinical issues and the remainder with clinical disorders. Subject material extends far beyond the field of psychopharmacology. The use of imaging techniques is not only discussed separately, but also permeates the discussions of both research and clinical issues.
Detection and quantitation of constriction of the fetal ductus arteriosus by Doppler echocardiography.
Authors: J C Huhta, K J Moise, D J Fisher, D S Sharif, N Wasserstrum, C Martin
Journal: Circulation (1987)

Pulmonary hypertension may occur in the fetus in the presence of constriction of the ductus arteriosus. The feasibility of detection and quantitation of fetal ductal constriction by Doppler echocardiography was assessed in an animal preparation in which ductal constriction was created in the fetal lamb with a variable ligature causing varying degrees of fetal pulmonary hypertension (fetal pulmonary arterial systolic pressure 57 to 97 mm Hg and ductal gradient 9 to 42 mm Hg). Comparison of blinded, continuous-wave peak Doppler velocity (V) measurements of the ductal gradient with the modified Bernoulli assumption (gradient = 4V2) compared well with direct catheter measurements of instantaneous peak systolic gradient (r = .99, catheter = 0.95 X Doppler + 0.6), peak-to-peak gradient (r = .97), and mid-diastolic gradient (r = .85). Ductal constriction was characterized by an increase in the peak systolic and diastolic velocities. The normal human fetal ductus arteriosus blood flow velocity pattern was assessed by pulsed Doppler techniques in 25 normal human fetuses after 20 weeks gestation. The peak systolic flow velocity in the ductus arteriosus measured by image-directed pulsed Doppler echocardiography ranged from 50 to 141 cm/sec (mean 80 cm/sec) and increased with gestational age (r = .50). Diastolic velocity in the ductus arteriosus was consistently directed toward the descending aorta and ranged from 6 to 30 cm/sec. The ductal systolic velocities were the highest blood flow velocities in the fetal cardiovascular system. Application of these techniques to fetuses whose mothers were receiving indomethacin for treatment of premature labor at 30 to 31 weeks gestation confirmed this method to be sensitive for detection of fetal ductal constriction, which developed in three fetuses.(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract 3907: Expression of vascular endothelial growth factor a (VEGF-A) in advanced gallbladder cancer.
Authors: Pablo Letelier, Kurt Buchegger, Carmen Ili, Patricia Garcia, Priscilla Brevi, Alejandra Sandoval, Pamela Leal, Ismael Riquelme, Juan Carlos Roa
Journal: Cancer Research (2013)

Abstract Gallbladder cancer (GBC) is a highly fatal disease with poor prognosis and few therapeutic alternatives. Molecular mechanisms involved in GBC pathogenesis remain poorly understood. The Vascular Endothelial Growth Factor A (VEGF) is a potent proangiogenic agent involved in the carcinogenesis of many human tumors and it is an attractive target for cancer therapy. The aim of this study was characterize VEGF expression in advanced gallbladder cancer and determine it's relationships with clinicopathologic features and utility as a prognostic factor. VEGF expression was examined by immunohistochemistry (IHC) in tissue microarrays containing 224 advanced gallbladder carcinomas and 39 cases of chronic cholecystitis (CC). The advanced GBC were classified as low or high expression to evaluate the association of VEGF expression level with clinical variables. Statistical analysis was performed using univariate analyses with a significance level of P&amp;lt;0.05; survival analysis was performed by the Kaplan- Meier method with the log-rank test. High expression of VEGF was observed in 183 of 224 (81%) tumors and 2 of 39 (5.1%) of chronic cholecystitis (P&amp;lt;0.0001). The VEGF expression had a significant relationship with clinical or pathological features included histological grade and TNM stage (P&amp;lt;0.05). Moreover, 5-year survival analysis indicated that high expression of VEGF is associated with a poor prognosis in patients with advanced gallbladder cancer (P = 0.0116). Our results indicate that VEGF is highly expressed in gallbladder cancer and correlates with poor prognostic, suggesting that VEGF expression could be used as a biomarker for predicting malignant behavior and to identify a subset of patients who may benefit from anti-VEGF therapies. Citation Format: Pablo Letelier, Kurt Buchegger, Carmen Ili, Patricia Garcia, Priscilla Brevi, Alejandra Sandoval, Pamela Leal, Ismael Riquelme, Juan Carlos Roa. Expression of vascular endothelial growth factor a (VEGF-A) in advanced gallbladder cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3907. doi:10.1158/1538-7445.AM2013-3907
Private company wins rights to Icelandic gene database
Authors: A. Berger
Journal: BMJ (1999)

The Icelandic parliament has passed a bill that has critical implications for countries around the world. The bill, passed on December 17, makes it legal for a private company to obtain a comprehensive electronic database containing health information about the entire population of Iceland.

The bill will also allow deCODE Genetics, a privately funded company based in Reykjavik, to manage the database, enabling the company to add both genetic and genealogical information to medical details that will be taken from hospital records. The final vote was taken after months of political wrangling, and only one member of the 41 strong coalition government voted against it.

deCODE Genetics, which is largely funded by American investors, has already signed a deal with the Swiss pharmaceutical company Hoffman-La Roche, giving them exclusive access to the database in order to establish the genetic origins of 12 diseases. Much of the growing opposition to the bill stems from the monopoly it clearly gives to a single company so that no other biotechnology or pharmaceutical company will have access to the data.

A significant …
Montelukast Prevents Antigen-induced Mucociliary Dysfunction in Sheep
Authors: Juan R. Sabater, Adam Wanner, William M. Abraham
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

The cysteinyl leukotrienes are potent proinflammatory mediators that, in addition to their bronchospastic actions, can also contribute to mucociliary dysfunction, a central component of the pathophysiology of asthma. In this study, we determined whether montelukast, a cysteinyl leukotriene 1 receptor antagonist, could prevent and/or reverse antigen-induced mucociliary dysfunction in allergic sheep. We measured tracheal mucus velocity, a marker of mucociliary clearance, before and for 8 hours after antigen challenge in six animals treated with montelukast (0.15 mg/kg, intravenously) 30 minutes before, 1 hour after, or 4 hours after antigen challenge. In the control trial, the sheep received 0.9% saline intravenously at each of the previously mentioned time points. The maximum decrease in tracheal mucus velocity seen in the control trial was 56 +/- 4% (mean +/- SE) of baseline at 8 hours. Pretreatment with montelukast significantly protected against this reduction. However, treatment at 1 and 4 hours neither protected against nor reversed the allergen-induced fall in tracheal mucus velocity. We conclude that the early release of cysteinyl leukotrienes may contribute to the fall in tracheal mucus velocity that follows acute antigen challenge and that pretreatment with montelukast reduces this impairment.