Cimetidine Therapy for Severe Hypercalcemia in Two Chronic Hemodialysis Patients
Authors: DOUGLAS LANIER
Journal: Annals of Internal Medicine (1980)

Brief Reports1 October 1980Cimetidine Therapy for Severe Hypercalcemia in Two Chronic Hemodialysis PatientsDOUGLAS LANIER Jr., M.D., HERVE FAVRE, M.D., ALLAN I. JACOB, M.D., JACQUES J. BOURGOIGNIE, M.D.DOUGLAS LANIER Jr., M.D.Search for more papers by this author, HERVE FAVRE, M.D.Search for more papers by this author, ALLAN I. JACOB, M.D.Search for more papers by this author, JACQUES J. BOURGOIGNIE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-4-573 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSpontaneous and persistent hypercalcemia in chronic hemodialysis patients, although rare, is usually associated with secondary hyperparathyroidism (1). When other causes of hypercalcemia are absent parathyroidectomy is indicated (2). We report two chronic hemodialysis patients with severe hypercalcemia who were successfully treated with Cimetidine for more than 6 months.Patient A is a 22-year-old black woman with sickle cell anemia in whom proteinuria and progressive renal failure developed in 1975. Chronic hemodialysis was initiated in January 1978. In February 1979, her serum calcium levels, which had ranged from 8.0 to 9.5 mg/dL, increased progressively over a 3month period to 9.9, 11.1,...References1. WINGCURTISEASTWOODSMITHDE WARDENER AJJEH. Transient and persistent hypercalcemia in patients treated by maintenance hemodialysis. Br Med J 1968;2:150-3. Google Scholar2. MASSRYCOBURN SJ. Divalent ion metabolism and renal osteodystrophy. In: MASSRY SG, SELLERS AL, eds. Clinical Aspects of Uremia and Dialysis. Springfield, Illinois: Charles C Thomas; 1976:304-88. Google Scholar3. JACOBLANIERCANTERBURYBOURGOIGNIE ADJJ. Cimetidine suppression of circulating parathyroid hormone in uremia. N Engl J Med. 1980;302:671-4. CrossrefMedlineGoogle Scholar4. BURCKARDTRUEDIFELBER PBJ. The clinical usefulness of the EDTA infusion as a stimulation test for parathyroid function. In: Calcium Regulating Hormones. Amsterdam: Excerpta Medica; 1975:75-9. Google Scholar5. BOURGOIGNIEJACOBGAVELLASCANTERBURY JAGJ. Effects of Cimetidine on parathyroid hormone in chronic uremia. In: MASSRY SG, ed. Fourth International Workshop on Phosphate and Other Minerals. New York: Plenum Publishing Corporation; 1980: in press. CrossrefGoogle Scholar6. BOURGOIGNIEJACOBLANIERGAVELLASCANTERBURY JADGJ. Cimetidine inhibition of iPTH in chronic renal disease. Kidney Int. 1979;16:918. Abstract. Google Scholar7. JACOBCANTERBURYGAVELLASBOURGOIGNIE AJGJ. Effect of Cimetidine (C) on calcium (Ca) and phosphate (P) homeostasis in chronic uremia. Clin Res. 1980;28:450A. Abstract. Google Scholar8. WILLIAMSLONGLEYHARGIS GRG. Effect of histamine on secretion of parathyroid hormone. Clin Res. 1979;27:704A. Abstract. Google Scholar9. LONGLEYHARGISBOWSER RGE. Parathyroid hormone and calcitonin secretion: role of histamine H2 receptors. Clin Res. 1980;28:398A. Abstract. Google Scholar10. BROWN E. Histamine receptors in parathyroid adenomas. Clin Res. 1980;28:388A. Abstract. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DOUGLAS LANIERJr., M.D.; HERVE FAVRE, M.D.; ALLAN I. JACOB, M.D.; JACQUES J. BOURGOIGNIE, M.D.Affiliations: University of Miami School of Medicine Miami, Florida University of Geneva Geneva Switzerland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMorphological and Histochemical Characteristics of Mast Cells and the Content of In-tissue Histamine in Various Pathological Parathyroids: Do Mast Cells Participate in Hormone Secretion in Human Parathyroids?FAdverse Reactions and Interactions with H2-Receptor AntagonistsLONG-TERM EFFECTS OF HISTAMINE H 2 -RECEPTOR ANTAGONISTS ON SERUM PARATHYROID HORMONE IN CHRONIC RENAL FAILUREMineral Metabolism in Health and DiseaseDrugs Five Years Later Cimetidine II. Adverse Reactions and Patterns of UseJAMES W. FRESTON, M.D., Ph.D.EFFECTS OF CIMETIDINE ON PARATHYROID HORMONE METABOLISM 1 October 1980Volume 93, Issue 4Page: 573-574KeywordsAnemiaCalciumHypercalcemiaHyperparathyroidismKidneysNephrologyParathyroid hormoneParathyroidectomyProteinuriaRenal failure ePublished: 1 December 2008 Issue Published: 1 October 1980 PDF downloadLoading ...