tbuckley/cabot-search huggingface dataset:
Abstract 783: Mutational status of the p53 tumor suppressor gene is associated with expression of GSTP1 allelic variants in human GBM..
Authors: Gamil R. Antoun, Francis Ali-Osman
Journal: Cancer Research (2013)

Abstract The tumor suppressor and transcription factor, p53, regulates the transcription of a large number of genes that control key cellular functional, such as, cell cycle arrest, DNA repair, senescence and apoptosis, and its mutational inactivation of p53 has been implicated in tumor development and progression. Mutation in p53 is a common genetic abnormality in GBM and other cancers and several studies have associated wild type p53 with high tumor drug resistance. Our laboratory previously reported that the polymorphic human GSTP1 gene is a transcriptional target of and is activated by p53 via a canonical p53 binding motif located in intron 4 of the GSTP1 gene. The ability of the p53 wild type to transcriptionally activate the GSTP1 gene, thus, defines a novel mechanism of protecting the genome and enhancement tumor drug resistance. The ability of the different GSTP1 alleles to protect against the toxicity of anticancer agents plays an important factor in this GSTP1-mediated tumor drug resistance. In a previous study, we showed that p53 mutations in GBM spanned the entire p53 gene, with the majority of the mutations in the DNA binding domain and that GSTP1 expression correlated, in most cases with wild type p53. In the present study, we examined the relationship between p53-dependent GSTP1 gene activation genetic polymorphism and expression in human GBM. We sequenced the p53 gene in 52 primary human GBMs, genotyped these tumors for their GSTP1 allelic status and determined the expression of the GSTP1 gene transcripts by quantitative PCR. The results showed the GSTP1*A allele to most highly (40%) expressed in the tumors and of these 27% harbored wild-type p53. In contrast, GSTP1*C allele was not only the least prevalent allele but also had the least association with wild-type p53. GSTP1*B, as well as, heterozygous GSTP1 alleles were intermediate in their association with p53 mutational status of the tumors. The level of expression of the individual genes also correlated with the presence of wild-type p53 in inversely with mutant p53. These results demonstrate a significant impact of p53 mutational status, not only in mediating the level of GSTP1 gene expression but also that it is related to the specific allelic form of GSTP1 that is expressed. This suggest that p53 mutational status and both GSTP1 expression and allele polymorphism may interact together to mediate glioma drug resistance. Citation Format: Gamil R. Antoun, Francis Ali-Osman. Mutational status of the p53 tumor suppressor gene is associated with expression of GSTP1 allelic variants in human GBM. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 783. doi:10.1158/1538-7445.AM2013-783
Tuberculosis and Indoor Biomass and Kerosene Use in Nepal: A Case–Control Study
Authors: Amod K. Pokhrel, Michael N. Bates, Sharat C. Verma, Hari S. Joshi, Chandrashekhar T. Sreeramareddy, Kirk R. Smith
Journal: Environmental Health Perspectives (2009)

In Nepal, tuberculosis (TB) is a major problem. Worldwide, six previous epidemiologic studies have investigated whether indoor cooking with biomass fuel such as wood or agricultural wastes is associated with TB with inconsistent results.Using detailed information on potential confounders, we investigated the associations between TB and the use of biomass and kerosene fuels.A hospital-based case-control study was conducted in Pokhara, Nepal. Cases (n = 125) were women, 20-65 years old, with a confirmed diagnosis of TB. Age-matched controls (n = 250) were female patients without TB. Detailed exposure histories were collected with a standardized questionnaire.Compared with using a clean-burning fuel stove (liquefied petroleum gas, biogas), the adjusted odds ratio (OR) for using a biomass-fuel stove was 1.21 [95% confidence interval (CI), 0.48-3.05], whereas use of a kerosene-fuel stove had an OR of 3.36 (95% CI, 1.01-11.22). The OR for use of biomass fuel for heating was 3.45 (95% CI, 1.44-8.27) and for use of kerosene lamps for lighting was 9.43 (95% CI, 1.45-61.32).This study provides evidence that the use of indoor biomass fuel, particularly as a source of heating, is associated with TB in women. It also provides the first evidence that using kerosene stoves and wick lamps is associated with TB. These associations require confirmation in other studies. If using kerosene lamps is a risk factor for TB, it would provide strong justification for promoting clean lighting sources, such as solar lamps.
Increasing Chemotherapy Intensity in Aggressive Lymphomas: A Renewal?
Authors: Bertrand Coiffier
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES ERRATA. November 01, 2016 ARTICLE CITATION DOI: 10.1200/JCO.2003.93.116 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12829662 Increasing Chemotherapy Intensity in Aggressive Lymphomas: A Renewal? Bertrand CoiffierxBertrand CoiffierSearch for articles by this author Show More Hospices Civils de Lyon and Université Claude Bernard, Lyon, France https://doi.org/10.1200/JCO.2003.93.116 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology Errata ERRATA
A CASE OF INFANTILE MYXEDEMA.
Authors: JAMES FREDERICK CLARKE
Journal: JAMA (1907)

The case here presented is the fourth of sporadic cretinism brought to my attention in this part of Iowa. Such a number found in a limited territory inclines me to the belief that the condition is much more frequent in the United States than is commonly supposed. <h3>Patient.</h3> —P. Z., male, aged 18 months, was sent to me by Dr. C. S. Bishop of Glasgow, Iowa. <h3>History.</h3> —This boy was the fourth child, of German parents who are first cousins. All other children of the family are normal. The baby weighed ten pounds at birth (Oct. 26, 1904), fourteen pounds when two months old, and sixteen pounds when eight months of age. There was obstinate constipation from the second month, and when nine months old the baby became deeply jaundiced and remained so for several months. An umbilical hernia developed at the same age. From the age of 9 months
Postprandial plasma retinyl ester response is greater in older subjects compared with younger subjects. Evidence for delayed plasma clearance of intestinal lipoproteins.
Authors: S D Krasinski, J S Cohn, E J Schaefer, R M Russell
Journal: Journal of Clinical Investigation (1990)

Postprandial vitamin A and intestinal lipoprotein metabolism was studied in 86 healthy men and women, aged 19-76 yr. Three independent experiments were carried out. In the first experiment, a supplement dose of vitamin A (3,000 retinol equivalents [RE]) was given without a meal to 59 subjects, aged 22-76 yr. In the second experiment, 20 RE/kg body wt was given with a fat-rich meal (1 g fat/kg body wt) to seven younger subjects (aged less than 50 yr) and seven older subjects (aged greater than or equal to 50 yr). In both experiments, postprandial plasma retinyl ester response increased significantly with advancing age (P less than 0.05). In the third experiment, retinyl ester-rich plasma was infused intravenously into nine young adult subjects (aged 18-30 yr) and nine elderly subjects (aged greater than or equal to 60 yr), and the rate of retinyl ester disappearance from plasma during the subsequent 3 h was determined. Mean (+/- SE) plasma retinyl ester residence time was 31 +/- 4 min in the young adult subjects vs. 57 +/- 8 min in the elderly subjects (P less than 0.05). These data are consistent with the concept that increased postprandial plasma retinyl ester concentrations in older subjects are due to delayed plasma clearance of retinyl esters in triglyceride-rich lipoproteins of intestinal origin.
Skin tolerability and efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A randomized, investigator-masked, controlled trial
Authors: R. Capizzi, F. Landi, M. Milani, P. Amerio
Journal: British Journal of Dermatology (2004)

Journal Article Skin tolerability and efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A randomized, investigator‐masked, controlled trial Get access R. Capizzi, R. Capizzi Clinica Dermatologica, Policlinico Universitario 'Agostino Gemelli', Rome, Italy *R&D Mipharm, Via B.Quaranta 12, 20141 Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar F. Landi, F. Landi Clinica Dermatologica, Policlinico Universitario 'Agostino Gemelli', Rome, Italy *R&D Mipharm, Via B.Quaranta 12, 20141 Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar M. Milani, M. Milani Clinica Dermatologica, Policlinico Universitario 'Agostino Gemelli', Rome, Italy *R&D Mipharm, Via B.Quaranta 12, 20141 Milan, Italy Massimo Milani. E‐mail: massimo.milani@mipharm.it Search for other works by this author on: Oxford Academic Google Scholar P. Amerio P. Amerio Clinica Dermatologica, Policlinico Universitario 'Agostino Gemelli', Rome, Italy *R&D Mipharm, Via B.Quaranta 12, 20141 Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 2, 1 August 2004, Pages 481–484, https://doi.org/10.1111/j.1365-2133.2004.06067.x Published: 01 August 2004 Article history Accepted: 01 February 2004 Published: 01 August 2004
Peptic Ulcerations Are Related to Systemic Rather Than Local Effects of Low-Dose Aspirin
Authors: Martijn G.H. van Oijen, Jeanne P. Dieleman, Robert J.F. Laheij, Miriam C.J.M. Sturkenboom, Jan B.M.J. Jansen, Freek W.A. Verheugt
Journal: Clinical Gastroenterology and Hepatology (2008)
Eosinophils and Blood Clotting
Authors: E. Keleman, M. Majoros, T. Janovics
Journal: BMJ (1951)

<h3>Abstract</h3> <h3>Objective</h3> To review interventions to reduce long term opioid treatment in people with chronic non-cancer pain, considering efficacy on dose reduction and discontinuation, pain, function, quality of life, withdrawal symptoms, substance use, and adverse events. <h3>Design</h3> Systematic review and meta-analysis of randomised controlled trials and non-randomised studies of interventions. <h3>Data sources</h3> Medline, Embase, PsycINFO, CINAHL, and the Cochrane Library searched from inception to July 2021. Reference lists and previous reviews were also searched and experts were contacted. <h3>Eligibility criteria for study selection</h3> Original research in English. Case reports and cross sectional studies were excluded. <h3>Data extraction and synthesis</h3> Two authors independently selected studies, extracted data, and used the Cochrane risk-of-bias tools for randomised and non-randomised studies (RoB 2 and ROBINS-I). Authors grouped interventions into five categories (pain self-management, complementary and alternative medicine, pharmacological and biomedical devices and interventions, opioid replacement treatment, and deprescription methods), estimated pooled effects using random effects meta-analytical models, and appraised the certainty of evidence using GRADE (grading of recommendations, assessment, development, and evaluation). <h3>Results</h3> Of 166 studies meeting inclusion criteria, 130 (78%) were considered at critical risk of bias and were excluded from the evidence synthesis. Of the 36 included studies, few had comparable treatment arms and sample sizes were generally small. Consequently, the certainty of the evidence was low or very low for more than 90% (41/44) of GRADE outcomes, including for all non-opioid patient outcomes. Despite these limitations, evidence of moderate certainty indicated that interventions to support prescribers’ adherence to guidelines increased the likelihood of patients discontinuing opioid treatment (adjusted odds ratio 1.5, 95% confidence interval 1.0 to 2.1), and that these prescriber interventions as well as pain self-management programmes reduced opioid dose more than controls (intervention <i>v</i> control, mean difference –6.8 mg (standard error 1.6) daily oral morphine equivalent, P&lt;0.001; pain programme <i>v</i> control, −14.31 mg daily oral morphine equivalent, 95% confidence interval −21.57 to −7.05). <h3>Conclusions</h3> Evidence on the reduction of long term opioid treatment for chronic pain continues to be constrained by poor study methodology. Of particular concern is the lack of evidence relating to possible harms. Agreed standards for designing and reporting studies on the reduction of opioid treatment are urgently needed. <h3>Review registration</h3> PROSPERO CRD42020140943.
Cardiovascular actions of palladium compounds in the unanesthetized rat.
Authors: M J Wiester
Journal: Environmental Health Perspectives (1975)

The natural occurrence of palladium (Pd) is rare. It is obtained as a by-product during the extraction of platinum and, until the present time, its uses were small in number--principally in the manufacture of jewelry, dental alloys, chemical catalysts, and electrical contacts. Interest in Pd toxicology has been limited to occupational exposures and even that has been sparse. Recently Pd has been chosen as one of the metals to be incorporated into the automotive catalytic converter material. Palladium chloride has been shown to be extremely toxic when given to rabbits intravenously. Animals rapidly injected quickly died with damage chiefly to the heart. This heart damage was not explained or further defined, and other references addressing this subject have not been found. The objective of our study was to investigate and attempt to characterize toxic actions of soluble Pd compounds on the cardiovascular system of the unanesthetized rat. Surgically prepared rats were monitored for ECG, aortic blood pressure, cardiac contractility (dp/dt), and respiration before, during, and 1 hr following intravenous injections of Pd2+ salt solutions. Our findings indicate that injected Pd2+ profoundly disturbs the electrical integrity of ventricular myocardium. Effective doses induce cardiac arrhythmias with the consequential fall in blood pressure; the extent of the response is dose related. An immediate cardiovascular effect is seen when doses of 0.4 mg/kg or more of Pd ion as PdSO4 is administered over a 40-sec period of time via the femoral vein. Pd(NO3)2 and PdCl2 appear to have similar activity. To achieve and equal response three times as much Pd is necessary as (NH4)2PdCl4 or K2PdCl4.
Cardiopulmonary Bypass to Repair an Atrial Septal Defect Does Not Affect Cognitive Function in Children
Authors: Peter L. Stavinoha, David E. Fixler, Lynn Mahony
Journal: Circulation (2003)

Changes in neurocognitive function after cardiopulmonary bypass (CPB) are difficult to assess in children with congenital cardiovascular malformations in part because identification of a suitable control group of children is difficult.We evaluated neurocognitive function in subjects aged 3 to 17 years both before and after surgical repair of an atrial septal defect (ASD). Eighteen subjects underwent testing within a median of 3 days (range, 1 to 27) before surgery and 5.8 months (range, 5.5 to 9) after surgery. The Differential Ability Scales was administered to subjects in a single testing session. All subjects were considered to be healthy, and they had no activity limitations. The mean General Conceptual Ability (GCA) scores (analogous to IQ) for the group were in the normal range before and after ASD repair. No significant difference was detected between the GCA scores before and after surgery. The GCA score was 90.8+/-18.6 before surgery and 93.1+/-16.3 after surgery.Use of CPB was not associated with changes in cognitive function in our subjects who underwent repair of an ASD.
1121-57 Increasing brachytherapy dose dramatically improves outcome in patients with long lesions
Authors: Paul S Teirstein, Jeffrey Moses, Martin Leon, Michael Collins, Roxanna Mehran, Eve Aymong, Manuela Neogota, Huan Giap, Ray Lin, Shirish Jani, Stephen Balter, Jack Dalton, Roberto Lipsztein, Neal Sawhney, Prabhakar Tripuraneni
Journal: Journal of the American College of Cardiology (2004)
Treatment of atopic eczema with oral alitretinoin
Authors: M. Grahovac, S. Molin, J.C. Prinz, T. Ruzicka, A. Wollenberg
Journal: British Journal of Dermatology (2009)

Conflicts of interest: M.G. and A.W. have received financial support and S.M., J.C.P. and T.R. have conducted clinical trials with alitretinoin and have received financial support from Basilea Pharmaceuticals GmbH, the manufacturer of oral alitretinoin. However, there was no financial support for the clinical observation submitted here. Madam, Chronic hand eczema (CHE) is a distressing disease of the palms with variable aetiology, severity and morphology. Clinical phenotypes essentially distinguish hyperkeratotic and dyshidrotic or mixed disease patterns. The underlying disease mechanisms include allergic contact dermatitis, irritative damage and atopy.1 Alitretinoin (9‐cis retinoic acid) is a novel antagonist vitamin A derivative, which binds both retinoic acid receptors (RAR) and retinoid X receptors (RXR). It has recently been licensed for oral treatment of CHE in several European countries.2 The clinical efficacy of alitretinoin for CHE has been confirmed in two large, randomized, double‐blinded, placebo‐controlled, clinical trials.3, 4 We wondered if oral alitretinoin would also be effective in extrapalmar atopic eczema (AE) lesions of patients with atopic CHE, or if side‐effects would limit its potential use in AE.
Book: Bodies of Evidence: Medicine and the Politics of the English Inquest, 1830-1926
Authors: M. F Maltese
Journal: BMJ (2001)

Ian A Burney Johns Hopkins University Press, £31, pp 176 ISBN 080186240X Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> For centuries, unnatural deaths in England have been subject to the scrutiny of a coroner's inquest—designed to determine a conclusive means of death in cases involving accidental or potentially criminal causation. In Bodies of Evidence Ian Burney chronicles the last century of the inquest, telling the tale of its medical and political reformers. Inquiry into mysterious deaths was initially seen as a duty of the government, to ensure the safety of its citizenry. In … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Atrial Fibrillation and Mitral Stenosis
Authors: NICHOLAS M. PAPAZOGLOU
Journal: Circulation (1974)

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Chronic arthritis associated with the presence of intrasynovial rubella virus.
Authors: R Grahame, R Armstrong, N Simmons, J.M Wilton, M Dyson, R Laurent, R Millis, C.A Mims
Journal: Annals of the Rheumatic Diseases (1983)

In this report we present 21 instances in which live rubella virus was isolated from synovial fluid obtained from 6 cases of inflammatory oligoarthritis or polyarthritis over a period of 2 years in the absence of firm clinical evidence of rubella. In 3 cases (cases 1, 2, 6,) a persistent oligoarthritis predominantly affecting the knee joints occurred in 2 adult women and one man, lasting to date 27, 29, and 18 months respectively, and in one of these cases virions were found in cells of the synovial membrane. In case 3 a boy of 9 presented with an illness indistinguishable from the systemic variety of juvenile chronic arthritis (Still's disease). In case 4 a young man with persistent monoarthritis was found to have ankylosing spondylitis, and in case 5 a progressive erosive polyarthritis developed 5 years after an attack of rubella complicated by rubella arthritis. The virus was identified by a variety of virological techniques and infection confirmed by immunofluorescence and (in one case) electron microscopy.
Evacuated Populations — Lessons from Foreign Refugee Crises
Authors: Phillip Nieburg, Ronald J. Waldman, Donald M. Krumm
Journal: New England Journal of Medicine (2005)

The terms “malfeasance” and “negligence” have been bandied about by many who are frustrated by the official response to Hurricane Katrina. Beginning with the evacuation orders before the hurricane's landfall, some public officials appeared to be trying hard to take the right steps. It appeared to us, however, that without any experience with crises of similar severity, and lacking guidelines and preparation for dealing with large displaced populations, such officials did not know what those right steps might be. For them, the experience must have been the uncomfortable public-policy equivalent of suddenly having to care for a critically ill patient . . .
Abstract P1-13-04: Immunohistochemical Evaluation of RANK/RANKL/OPG Axis and CXCR4 in Primary Breast Cancer and Their Role in Bone Metastasization
Authors: T Ibrahim, E Sacanna, M Gaudio, L Mercatali, R Ricci, E Scarpi, P Serra, F Fabbri, L Serra, D. Amadori
Journal: Cancer Research (2010)

Abstract Background: The RANK/RANKL/OPG axis plays an important role in the bone metastasization process. CXCL12 is overexpressed in bone and, like its receptor, CXCR4, is a determinant of organ tropism. The objective of the present study was to evaluate whether the expression of these markers in primary breast cancer can predict the onset of bone metastases. Methods: Marker expression was evaluated by immunohistochemical staining in paraffin-embedded sections of primary breast cancers from 40 individuals: 10 patients (median age 64 years, range 48-78) showed no evidence of disease (NED — control group) at a median of 9.8 (range 6.9-11.5) years, while 30 (median age 67 years, range 42-87) had relapsed. In the latter group, 10 (median age 66 years, range 42-87) had visceral metastases (VM — control group) and 20 (median age 69 years, range 42-87) had bone metastases (BM — case group), both confirmed radiologically. The 3 patient subgroups (NED, visceral lesions, bone lesions) were matched for age classes (≥60 years, &amp;gt; 60 years). The study design was reviewed and approved by the local ethics committee. Results: In the overall series, 17.5% of tumors were positive for RANK, 22.5% for OPG and 25% for CXCR4. None of the patients expressed RANKL. RANK and OPG resulted equally expressed in 20% of NED patients, while CXCR4 was expressed in only 10% of this group. OPG was expressed in 20% of VM patients, whereas RANK or CXCR4 were not detected. RANK and OPG positivity was present in 25% of BM patients, while CXCR4 was expressed in 45% of cases. CXCR4 was the only marker with a significantly higher frequency of expression in bone metastases than in visceral lesions (p=0.013). Taking into consideration all the patients without bone involvement (NED plus VM patients), it was observed that CXCR4 expression, alone and in combination with RANK, significantly discriminated between BM patients and the control group (p=0.008 and P&amp;lt;0.001, respectively). ER-positivity and HER2-negative status were observed in 80% and 95% of BM patients, respectively, but neither discriminated between cases and controls. Conclusions: In our study, ER-positivity and HER2- negativity identified a high percentage of bone relapse patients, but also highlighted patients who did not have bone involvement. RANK and CXCR4 expression, on the other hand, would appear to be a more accurate predictor of bone relapse. Such evidence could help to identify patients with a high probability of developing bone metastases, which can be treated with bisphosphonates or other bone-targeted therapies, such as denosumab, in an attempt to prevent distant metastases. Our results are currently being validated in a larger series of breast cancer patients. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P1-13-04.