tbuckley/cabot-search huggingface dataset:
Use of the Activated Partial Thromboplastin Time
Authors: Erich Kuss
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 August 1988Use of the Activated Partial Thromboplastin TimeErich Kuss, MDErich Kuss, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-4-347_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In connection with a recent article (1), I pose a question.Should peridural anesthesia in women with otherwise normal bleeding history be preceded by coagulation tests to prevent unexpected bleeding in the central nervous system?...Reference1. SuchmanGriner AP. Diagnostic uses of the activated partial thromboplastin time and prothrombin time. Ann Intern Med. 1986;104:810-6. LinkGoogle Scholar1. Feinstein A. The 'chagrin factor' and qualitative decision analysis. Arch Intern Med. 1985;145:1257-9. CrossrefMedlineGoogle Scholar2. Bell D. Regret in decision making under uncertainty. Oper Res. 1982;30:961-81. CrossrefGoogle Scholar3. WilliamsSuchman GA. Regret and preoperative testing [Abstract]. Med Decis Making. 1986;6:268. Google Scholar4. SuchmanMushlin AA. How well does the activated partial thromboplastin time predict postoperative hemorrhage? JAMA. 1986;256:750-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: I. Frauenklinik der Universität 8000 Munich 2 West Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1988Volume 109, Issue 4Page: 347-347KeywordsAnesthesiaCentral nervous systemHemorrhagePartial thromboplastin time Issue Published: 15 August 1988 PDF downloadLoading ...
Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function
Authors: Yang Liu, Colin A. Kretz, Morgan L. Maeder, Catherine E. Richter, Philip Tsao, Andy H. Vo, Michael C. Huarng, Thomas Rode, Zhilian Hu, Rohit Mehra, Steven T. Olson, J. Keith Joung, Jordan A. Shavit
Journal: Blood (2014)
Abstract 4651: Elevated serum tissue inhibitor of metalloproteinases-1 (TIMP-1) level predicts shorter survival in ovarian cancer
Authors: Navid Jamshidi, Vikas Shrivastava, Kim Leitzel, Suhail Ali, Edward Podczask, Colin Macneill, Timothy Deimling, Sheryl Brown-Shimer, Karen Pierce, Walter Carney, Syed Rizvi, Kamal Abbi, Allan Lipton
Journal: Cancer Research (2010)

Abstract Body: Background: Matrix metalloproteinases (MMPs) play a key role in invasion and metastasis of cancer cells. MMPs are able to degrade extracellular matrix and aid formation of new blood vessels, thus supporting metastatic tumor growth and angiogenesis. The MMP family can be regulated by their inhibitors, the tissue inhibitor of metalloproteinases (TIMPs), which bind MMPs noncovalently. TIMP-1 has paradoxical multifunctional roles in tumorigenesis, independent of its original MMP-inhibitory role: growth promotion, inhibition of apoptosis, and regulation of angiogenesis. Overexpression of TIMP-1 confers resistance to chemotherapy in cell culture, and increased TIMP-1 has been associated with an unfavorable prognosis in multiple cancer types. TIMP-1 has recently been reported to be a predictive biomarker in large human breast cancer trials. The purpose of this study was to determine the correlation between serum TIMP-1 levels at the time of diagnosis in patients with ovarian cancer and correlate this biomarker with overall survival. Methods: Serum TIMP-1 was assayed from 36 patients diagnosed with ovarian cancer between 1982 and 1987. Blood was collected at the time of diagnosis and serum frozen. Serum TIMP-1 levels were measured using a TIMP-1 ELISA from Oncogene Science / Siemens Healthcare Diagnostics (Cambridge, MA). Clinical outcome data were correlated with serum TIMP1 levels. Results: TIMP-1 levels from 36 patients had a mean of 559 ng/ml with SD of + 296 (range 145 to 1460 ng/ml). 35 of 36 patients had clinical follow up data available. 82.14% of patients had distant metastasis, 7.14 % had localized tumor, and 10.71 % had regional involvement. Elevated serum TIMP-1 level predicted shorter survival in ovarian cancer by quartile analysis (p=0.022). Median survival was 4079 days for patients with the lowest serum TIMP-1 quartile, and 106 days for those with the highest serum TIMP-1 quartile. On a continuous basis, higher serum TIMP-1 trended to predict significant shorter survival (p=0.063). Conclusions: Elevated serum TIMP-1 levels at the time of diagnosis predicted shorter survival in ovarian cancer. Circulating TIMP-1 deserves further study as a predictive and prognostic factor in ovarian cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4651.
Nasal Pain After Injury: Cure by Procaine
Authors: G. Fennell, D. M. L. Williams
Journal: BMJ (1962)

Nasal Pain after Injury : Cure by Procaine Causalgia is a state resulting from injury involving a peripheral nerve.It consists of persistent burning pain, usually beginning at the site of injury and often radiating for some distance from this point.The pain may continue intermittently for months or even years.It may begin at the time of injury, or its onset may be delayed for days or weeks.The skin over the affected area is frequently hot and red.Causalgia has been reported many times after injury to the median and sciatic nerves, but we can find no reference to the condition after injury to the nose. CASE REPORTSCase 1.-A man aged 32 attended because of intense
11 SUSTAINED VIROLOGIC RESPONSE (SVR) IN PRIOR PEGINTERFERON/RIBAVIRIN (PR) TREATMENT FAILURES AFTER RETREATMENT WITH BOCEPREVIR (BOC)-+-PR: THE PROVIDE STUDY INTERIM RESULTS
Authors: J.P. Bronowicki, M. Davis, S. Flamm, S. Gordon, E. Lawitz, E. Yoshida, J. Galati, V. Luketic, J. McCone, I. Jabobson, P. Marcellin, A. Muir, F. Poordad, L.D. Pedicone, W. Deng, M. Treitel, J. Wahl, J. Vierling
Journal: Journal of Hepatology (2012)
Arrhythmias and Cardiac Arrest-Reply
Authors: Bruce Logue
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In reply to the comment by Drs. Berkowitz and Greene, isoproterenol is, in general, a depressor drug; at times, through its inotropic effect, it may produce elevation of the systolic pressure, with a widening of the pulse pressure. Methoxamine, on the other hand, has almost a purely peripheral action (Goldberg and others: Comparative Heart Contractile Force Effects of Equipressor Doses of Several Sympathomimetic Amines,<i>J Pharmacol Exp Ther</i><b>108</b>:177-185 [June] 1953). In regard to the occurrence of ventricular tachycardia induced by methoxamine, it is well known that any maneuver producing reflex increase in vagal tone can initiate ventricular arrhythmias, including such things as carotid sinus stimulation or the Valsalva maneuver. Certainly any of the sympathomimetic drugs, whether their action is predominantly peripheral or central, can induce such arrhythmia. One needs to keep in mind not only the inotropic effect, with stimulation of ventricular pacemakers, but also
Lessons learned? Chemical plant safety since Bhopal.
Authors: Ernie Hood
Journal: Environmental Health Perspectives (2004)

It was 3 December 1984, a quiet night in Bhopal, India, until a cascade of catastrophic circumstances, system failures, and outright negligence at the Union Carbide pesticide plant led to the accidental release of approximately 40 metric tons of acutely toxic methyl isocyanate (MIC).The dense cloud of deadly vapor spread over the sleeping community.Estimates of immediate and long-term casualties vary; the U.S. Chemical Safety and Hazard Investigation Board (CSB), an independent federal agency, cites more than 3,000 people dying within a few days and at least 100,000 injured.The event is widely acknowledged to be the worst industrial accident in history, leaving as many as 50,000 people partially or totally disabled as of 1994, according to the International Medical Commission on Bhopal.The incident also left a morass of civil and criminal litigation in its wake, as survivors continue their effort to recover what they consider to be appropriate compensation for their long-term pain and suffering.As the twentieth anniversary of the Bhopal incident arrives later this year, there inevitably will be a renewed focus on its impact on safety within the chemical industry worldwide."Bhopal was a wake-up call for the industry," says chemical engineer Sam Mannan, director of the Mary Kay O'Connor Process Safety Center at Texas A&M University, echoing the opinion of many experts in the field.Although it seems clear that Bhopal has had a positive legacy in improved chemical plant safety, particularly in the United States, to this day there is no single, reliable, quantifiable method to answer a very simple, reasonable, and vitally important question: How safe are chemical plants today, and are they really any safer today than they were 20 years ago?"I wish somebody had a good solid finger on the pulse of chemical safety, but we really don't have that in [the United States] right now," says CSB toxicologist Gerald Poje.Mannan concurs: "It's really impossible to answer the question 'Are we doing better or worse?' without having data, without having statistics."Of that lack of data, he says, "I won't hesitate to use the word 'scandalous,' because it is." Bill TompkinsFocus | Lessons Learned?Reaction and action.A 1998 runaway chemical reaction at the Morton International plant in Paterson, New Jersey, helped call greater attention to this particular industry hazard.
Observations on Asthma Mortality
Authors: E.R. McFadden
Journal: Annals of Internal Medicine (1997)

The rate of death from asthma in the United States has been increasing over the last decade, but such deaths still remain uncommon.Mortality rates differ markedly by region and ethnicity, and case-fatality rates are highest in black men living in inner cities. In general, patients in greatest jeopardy are those with severe, unstable disease who are not being objectively monitored; however, death can occur in anyone if the attack is intense enough. Sudden catastrophic episodes of asthma occur but are very rare. Failure to recognize the seriousness of the terminal episode or to treat the episode appropriately remains the chief contributing cause of poor outcome. Little compelling evidence shows that adverse effects of medications play much of a role in asthma-related death. The disease characteristics that place patients at risk remain inadequately defined. Of those suggested, only a history of recurrent hospitalization and the need for ventilatory assistance are specific enough to be helpful. These characteristics, however, are found in only 36% and 6% of cases, respectively; thus, their absence is of no value in assessing risk. The prognosis after a near-fatal episode of asthma is poor, and approximately 10% of patients die in the year after the event. Given the current state of knowledge, it is wise to view all exacerbations of asthma that last longer than a few days as potentially fatal and to treat them accordingly. This is especially true in patients who have previously had a severe episode of asthma.
Development secretary says UK contribution to Global Fund depends on fund making progress on its reforms
Authors: A. Gulland
Journal: BMJ (2012)

International development secretary Andrew Mitchell has given strong backing to the Global Fund to fight AIDS, Tuberculosis, and Malaria but stopped short of announcing an immediate boost in financial aid.

Mitchell was giving evidence to MPs on the international development select committee, which was holding a special one off evidence session to investigate the cancellation of the Global Fund’s latest funding round in November after a shortfall in donations.

Mitchell began his evidence by saying that the UK would make a “significant uplift for 2013-14 at the turn of the year.” After questioning by MPs, however, he said that he might make his announcement earlier than that, possibly at the next G20 meeting in Mexico in June. Since 2001 …
Ebola outbreak claims more than 60 lives
Authors: A. Gulland
Journal: BMJ (2014)

Doctors are fighting to contain an outbreak of Ebola haemorrhagic fever in Guinea that has claimed more than 60 lives and is now being reported in the capital, 400 miles away.

As of 27 March, the World Health Organization said that there had been 103 suspected and confirmed cases of the disease, including 66 deaths. WHO said it could not confirm all cases because of the rapidly changing situation.

Most of the cases have been reported in three districts in the south east of the west African country, Gueckedou, Macenta, and Kissidougou, but five cases have also been reported in the capital, Conakry. Neighbouring Liberia and Sierra Leone have also reported cases …
Atorvastatin-Induced Polyneuropathy
Authors: Michael B. Jacobs
Journal: Annals of Internal Medicine (2004)

Letters6 July 2004Atorvastatin-Induced PolyneuropathyMichael B. Jacobs, MDMichael B. Jacobs, MDFrom Stanford University, Palo Alto, CA 94304.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-1-200407060-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was interested to read Dr. Silverberg's letter about atorvastatin-induced polyneuropathy (1). Although Dr. Silverberg was able to find only a single article on this phenomenon, others have been reported, including a letter published in Annals 10 years ago (2). An additional 7 cases were subsequently described (3). Some of the reported patients had irreversible symptoms, possibly related to prolonged exposure to the statin (4 to 7 years). Given the ubiquitous use of this class of drug, it is important that physicians be aware of this potential toxicity.References1. Silverberg C. Atorvastatin-induced polyneuropathy [Letter]. Ann Intern Med. 2003;139:792-3. [PMID: 14597471] LinkGoogle Scholar2. Jacobs MB. HMG-CoA reductase inhibitor therapy and peripheral neuropathy [Letter]. Ann Intern Med. 1994;120:970. [PMID: 8172444] LinkGoogle Scholar3. Jeppesen U, Gaist D, Smith T, Sindrup SH. Statins and peripheral neuropathy. Eur J Clin Pharmacol. 1999;54:835-8. [PMID: 10027656] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Michael B. Jacobs, MDAffiliations: From Stanford University, Palo Alto, CA 94304. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHMG-CoA Reductase Inhibitor Therapy and Peripheral Neuropathy Michael B. Jacobs Atorvastatin-Induced Polyneuropathy Chad Silverberg Metrics Cited byStatin Safety: An Overview and Assessment of the Data—2005 6 July 2004Volume 141, Issue 1Page: 77KeywordsAdverse reactionsStatinsToxicity ePublished: 6 July 2004 Issue Published: 6 July 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Differentiation of Embryonic Stem Cells Into Hepatocytes: Biological Functions and Therapeutic Application
Authors: Hanako Yamamoto, Gary Quinn, Akira Asari, Hiroko Yamanokuchi, Takumi Teratani, Masaaki Terada, Takahiro Ochiya
Journal: Hepatology (2003)

Embryonic stem (ES) cells provide a unique source for tissue regeneration. We examined whether mouse ES cells can efficiently differentiate into transplantable hepatocytes. ES cells were implanted into mouse livers 24 hours after carbon tetrachloride intoxication; ES-derived cells with several hepatocyte-cell-markers were generated. They were able to grow in vitro and showed morphology consistent with typical mature hepatocytes and expressed hepatocyte-specific genes. After transplantation into the carbon tetrachloride-injured mouse liver, ES-derived green fluorescent protein-positive cells were incorporated into liver tissue and rescued mice from hepatic injury. No teratoma formation was observed in the transplant recipients. In conclusion, ES cells can provide a valuable tool for studying the molecular basis for differentiation of hepatocytes and form the basis for cell therapies.
New, Poorly Recognized Echocardiographic Findings
Authors: Samuel Zoneraich
Journal: JAMA (1976)

New, poorly recognized echocardiographic findings were recorded in six patients with pericardial effusion. These findings were apparent prolapse of mitral and tricuspid valves, apparent systolic anterior motion of mitral valve, and midsystolic notching of pulmonic valve. Beat-to-beat variation of the dimensions of right and left ventricle and in the diastolic opening amplitude of the anterior mitral valve were present in cardiac tamponade. Substantial decrease or resolution of effusion resulted in disappearance of the observed abnormalities. Serial echographic studies before and after fluid resolution may prevent misleading echographic and clinical diagnoses.
Targeting the KIT activating switch control pocket: a novel mechanism to inhibit neoplastic mast cell proliferation and mast cell activation
Authors: Y Bai, G Bandara, E Ching Chan, I Maric, O Simakova, S N Bandara, W-P Lu, S C Wise, D L Flynn, D D Metcalfe, A M Gilfillan, T M Wilson
Journal: Leukemia (2012)
Low Toxicity of Carbimazole
Authors: C. D. Burrell, R. Fraser, D. Doniach
Journal: BMJ (1956)

Woods (1952) described the case of a man of 46 admitted to hospital with burns and shock following lightning.Ten weeks later he developed " pins-and-needles " in the fingertips, spasm of the forearm muscles, and weakness of both legs.A diagnosis of spinal atrophic paralysis resembling amyotrophic lateral sclerosis was made.He made an almost complete recovery in eight weeks.Girard, Garde, and Jacquot (1954) described the case of a woman who was struck by lightning.She had momentary loss of sensation in her legs accompanied by pain, which soon passed off.Eight days later, however, progressive weakness of the legs began, making walking impossible.There was also marked weakness of the arms with pain in all four limbs.Considerable improvement took place later, though some weakness persisted.Critchley (1934) described the pathological findings follow- ing death from injury by lightning.He found scattered petechiae throughout the brain, medulla, and spinal cord, especially around the anterior horn cells.Similar petechiae were found in the peripheral nerves and muscles.Schallock (1952) described an incident where two juvenile football teams were struck by lightning, several players being thrown to the ground.One, a boy of 16 years, was killed.Post-mortem examination revealed no burns, but a minute wound in the web between the second and third toes of the right foot with minimal bleeding.The boot on this foot was torn open, but there were no burn marks on it.The metal nails and eyelets were blackened.Death was thought to be due to shock, the boy having been struck by lightning in the right foot.Marriott (1951) recommended artificial respiration in suitable cases, prolonged for several hours if necessary, and the injection of nikethamide intravenously.Plasma transfusions would be required for extensive burns.In this present series there was a wide variety of lesions, varying from mild paraesthesia and feathering burns of the skin to severe head injuries and full-thickness burns.It was interesting that a large number of minor burns occurred, but only one case of burns remained in hospital after 10 days.In this instance full recovery took place without grafting.There was also a wide variety of burns, several types sometimes being seen in the same patient.Finally, in no case was extensive deep necrosis present beneath the skin as is so often seen in electrical burns, despite the number of cases in which burns with small areas of full-thickness skin loss were found.
Trust chiefs cause flood of serious cases to GMC
Authors: K. Burke
Journal: BMJ (2002)

Nearly two thirds of professional conduct complaints languish for more than a year between committees because of an upsurge in the number of serious cases referred to the General Medical Council.

The GMC has admitted that some “fitness to practise” complaints take over two years to deal with because the Professional Conduct Committee (PCC) cannot keep up with the caseload referred to it.

Fitness to practise figures show that the committee heard only 35% of conduct cases within a year, compared with a …
The use of three-dimensional nanostructures to instruct cells to produce extracellular matrix for regenerative medicine strategies
Authors: Katja Schenke-Layland, Fady Rofail, Sanaz Heydarkhan, Jessica M. Gluck, Nilesh P. Ingle, Ekaterini Angelis, Chang-Hwan Choi, William R. MacLellan, Ramin E. Beygui, Richard J. Shemin, Sepideh Heydarkhan-Hagvall
Journal: Biomaterials (2009)
Charity calls for ban on cluster bombs
Authors: P. Moszynski
Journal: BMJ (2002)

Landmine Action—a UK umbrella group of concerned organisations—is calling for the concerted clearance of “explosive remnants of war” and a moratorium on cluster bombs until new international humanitarian law is in place.

The move comes as part of landmine action week, 4-10 November. Unexploded cluster bombs are similar to landmines: “As there is no way of distinguishing between soldiers and civilians, their use is indiscriminate, and that is in clear breach of international law,” says the group.

The United States dropped 600 cluster bombs on Afghanistan in its initial bombing campaign, according to research by the charity Human Rights Watch. Each …
Aspiration biopsy of thoracic lesions
Authors: A. F. Lalli, B. Naylor, W. M. Whitehouse
Journal: Thorax (1967)

We have performed percutaneous needle aspiration biopsy of intrathoracic lesions under fluoroscopic control on 50 patients. Lesions as small as 1 to 1·5 cm. in diameter were aspirated. Thirty of the 36 cases of malignant neoplasm were diagnosed by this method. Of the 14 non-neoplastic cases, granuloma was diagnosed in two, and in eight of the remaining 12 the clinical diagnosis was supported by the nature of the aspirated material. Pneumothoraces are to be expected as a complication of the method. Most will be asymptomatic; a small proportion will require treatment. There will also be the occasional haemoptysis. The procedure can be quickly performed and it is well tolerated by the patient. It causes less discomfort than bronchoscopy or scalene lymph node biopsy. The interpretation of the cytological material presents no undue difficulty to the pathologist experienced in conventional pulmonary exfoliative cytology.