Dietary Treatment of Type V Hyperlipoproteinemia Fails to Normalize Low Levels of High-Density Lipoprotein Cholesterol
Authors: JAMES M. FALKO
Journal: Annals of Internal Medicine (1979)

Brief Reports1 November 1979Dietary Treatment of Type V Hyperlipoproteinemia Fails to Normalize Low Levels of High-Density Lipoprotein CholesterolJAMES M. FALKO, M.D., JOSEPH L. WITZTUM, M.D., GUSTAV SCHONFELD, M.D., JOYCE BATEMAN, R.D.JAMES M. FALKO, M.D.Search for more papers by this author, JOSEPH L. WITZTUM, M.D.Search for more papers by this author, GUSTAV SCHONFELD, M.D.Search for more papers by this author, JOYCE BATEMAN, R.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-750 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent epidemiologic and experimental data suggest that high-density lipoproteins may protect against the development of atherosclerosis (1, 2). Cross-sectional population studies have shown that plasma triglyceride values are inversely related to high-density lipoprotein-cholesterol values in both normal and hyperlipidemic populations (3). This has led to the suggestion that therapeutic lowering of plasma triglyceride levels would result in elevation of high-density lipoprotein-cholesterol levels. However, in a prospective longitudinal study of subjects with type IV hyperlipoproteinemia, we have shown that hypocaloric diet-induced normalization of plasma triglyceride levels failed to correct their initially low high-density lipoprotein-cholesterol values (4). In contrast, in response to...References1. RHOADSGULBRANDSENKAGAN GCA. Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men. N Engl J Med. 1976;294:293-8. CrossrefMedlineGoogle Scholar2. MILLERWEINSTEINCAREWKOSCHINSKYSTEINBERG NDTTD. Interaction between high density and low density lipoproteins during uptake and degradation by cultured human fibroblasts. J Clin Invest. 1977;60:78-88. CrossrefMedlineGoogle Scholar3. SCHAEFFERANDERSONDANNERBREWERBLACKWELDER EDRHW. Plasma-triglycerides in regulation of H.D.L.-cholesterol levels. Lancet. 1978;2:391-2. CrossrefMedlineGoogle Scholar4. WITZTUMDILLINGHAMGIESESCHONFELDWEIDMAN JMWGS. Triglyceride lowering fails to correct low high-density lipoprotein-cholesterol in primary hypertriglyceridemia (type IV). Circulation. 1978;58 (suppl II):II38. Abstract. Google Scholar5. FALKOWITZTUMSCHONFELDWEIDMANKOLAR JJGSJ. Type III hyperlipoproteinemia: rise in high-density lipoprotein levels in response to therapy. Am J Med. 1979;66:303-10. CrossrefMedlineGoogle Scholar6. FREDRICKSONGOLDSTEINBROWN DJM: Familial hyperlipoproteinemia. In: STANBURY JB, WYNGAARDEN JB, FREDRICKSON DS, eds. The Metabolic Basis of Inherited Disease. New York: McGraw-Hill; 1978:604-56. Google Scholar7. Dietary Management of Hyperlipoproteinemia, A Handbook for Physicians and Dietitians. DHEW Publication No. (NIH) 75-110, Bethesda: National Heart and Lung Institute; 1974. Google Scholar8. Manual of Laboratory Operations, Lipid Research Clinics Program. DHEW Publication No. NIH-75-628. Bethesda: National Heart and Lung Institute; 1974. Google Scholar9. RIFKINDTAMIRHEISSWALLACETYROLER BIGRH. Distribution of high density and other lipoproteins in selected LRC prevalence study populations: a brief survey. Lipids. 1979;14:105-12. CrossrefMedlineGoogle Scholar10. PATSCHGOTTOOLIVECRONAEISENBERG JATS. Formation of high density lipoprotein like particles during lipolysis of very low density lipoproteins in vitro. Proc Natl Acad Sci USA. 1978;75:4519-4523. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lipid Research Center Department of Preventive Medicine Washington University School of Medicine St. Louis, MissouriThe authors appreciate the assistance of the Lipid Research Clinic staff and the Core Laboratory.Supported in part by NIH Contract N01-HV-2-2916-L (Lipid Research Clinics Program). Dr. Falko was supported by U.S. Public Health Service Training Grant 1F32-HL05566-01. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIIIOne third of the variability in HDL‐cholesterol level in a large dyslipidaemic population is predicted by age, sex and triglyceridaemia:The Paris La Pitié StudyTriglycerides and HDL-cholesterol as risk factors for ischemic heart disease. Results from the Québec cardiovascular studyDiet and lifestyle modification and its relationship to atherosclerosisEffect of reduction of plasma triglycerides with gemfibrozil on high-density-lipoprotein-cholesterol concentrationsRelationship of triglycerides and HDL cholesterol in hypertriglyceridemiaDOES DIETARY THERAPY FOR HYPERLIPOPROTEINEMIA TYPE V PREDISPOSE TO PREMATURE ATHEROSCLEROSIS?Modifications of plasma lipoproteins after lipase activation in patients with chylomicronemia.Nutritional Management of Plasma Lipid DisordersHDL Subclasses and AtherosclerosisThe Plasma Lipoproteins in Hypertriglyceridemia as Risk Factors for AtherosclerosisLipoprotein modifications during dietary treatment in patients with primary type V hyperlipoproteinaemiaFette und Niereninsuffizienz — Therapeutische AspekteRegulation of High Density Lipoprotein LevelsUnterschiedliche Beeinflussung der Plasma- und Lipoproteinlipide durch Gewichtsreduktion bei übergewichtigen Patienten mit kombinierter Hyperlipoproteinämie (HLP Typ IV)Diet and high density lipoproteinsNormalization of Triglycerides in Type IV Hyperlipoproteinemia Fails to Correct Low Levels of High-Density-Lipoprotein Cholesterol 1 November 1979Volume 91, Issue 5Page: 750-751KeywordsAtherosclerosisBlood plasmaEpidemiologyHigh density lipoproteinHigh density lipoprotein cholesterolHypocaloricLipidsLongitudinal studiesMedical servicesResearch laboratories Issue Published: 1 November 1979 PDF downloadLoading ...