tbuckley/cabot-search huggingface dataset:
Nanocarriers with ultrahigh chromophore loading for fluorescence bio-imaging and photodynamic therapy
Authors: Julien R.G. Navarro, Frédéric Lerouge, Cristina Cepraga, Guillaume Micouin, Arnaud Favier, Denis Chateau, Marie-Thérèse Charreyre, Pierre-Henri Lanoë, Cyrille Monnereau, Frédéric Chaput, Sophie Marotte, Yann Leverrier, Jacqueline Marvel, Kenji Kamada, Chantal Andraud, Patrice L. Baldeck, Stephane Parola
Journal: Biomaterials (2013)
Contribution of Metabolic Syndrome Components to Cognition in Older Individuals
Authors: Miranda G. Dik, Cees Jonker, Hannie C. Comijs, Dorly J.H. Deeg, Astrid Kok, Kristine Yaffe, Brenda W. Penninx
Journal: Diabetes Care (2007)

Recent evidence suggests that the metabolic syndrome and inflammation affect cognitive decline in old age and that they reinforce each other. However, it is not known what the roles of the individual components of the metabolic syndrome on cognition are.The sample consisted of 1,183 participants in the Longitudinal Aging Study Amsterdam who were aged 65-88 years. Metabolic syndrome (U.S. National Cholesterol Education Program definition) and its individual components and the inflammatory markers C-reactive protein (CRP) and alpha1-antichymotrypsin (ACT) were assessed. Cognitive assessments included general cognition (Mini-Mental State Examination), memory (verbal learning test), fluid intelligence (Raven's Matrices), and information processing speed (coding task).Of the sample, 36.3% had metabolic syndrome. Metabolic syndrome was significantly associated with all cognitive measures (P < 0.05). Of the individual components, hyperglycemia was most strongly and significantly associated with cognitive function (multivariate adjusted models; B values, indicating differences in scores between both groups, ranging from -0.38 to -1.21). There was a significant interaction between metabolic syndrome and inflammation on cognition (P < 0.01-0.09). Metabolic syndrome was negatively associated with cognition in subjects with high inflammation (highest tertile for both CRP and ACT; B values ranging from -0.86 to -1.94, P < 0.05), whereas an association was absent in subjects with low inflammation (B values ranging from -0.10 to -0.70).Subjects with metabolic syndrome showed poorer cognitive performance than subjects without metabolic syndrome, especially those with high levels of inflammation. Hyperglycemia was the main contributor of the association of metabolic syndrome with cognition.
Phylogenetic Methodology for Detecting Protein Interactions
Authors: P. J. Waddell, H. Kishino, R. Ota
Journal: Molecular Biology and Evolution (2006)

Detecting protein-protein interactions and assigning proteins to functional complexes are key challenges of modern biology. The rise of genomics has lead to evidence that correlated patterns of presence/absence and/or fusing of proteins in any organism suggest these proteins interact. Unfortunately, methods based on such data work best with divergent genomes, whereas major sequencing efforts in vertebrates, for example, are yielding alignments of the same set of proteins sampled from the same set of taxa (species). Using vertebrate mitochondrial genomes to illustrate a novel method, we associate proteins based on vectors of their evolutionary tree edge (branch or internode) lengths. This approach is based on the expectation that molecular coevolution is greatest between proteins that interact in some way. Mitochondrial DNA-encoded proteins are associated into groups largely consistent with the complexes they come from. This association is apparently not due to the tree structure or mutation processes, leaving coevolution as the best explanation. We show that it is important that the tree used to derive the edge-length vector is estimated accurately in terms of both topology and edge lengths. Although more complex substitution models reduce systematic error, they also inflate stochastic error. This makes the use of less complex substitution models preferable in some circumstances. We describe a method to estimate correlations of pairwise evolutionary distances, which adjusts for non-independent correlations due to shared evolutionary history. Associations of proteins based on their edge-length vectors are visualized and assessed using a variety of hierarchical clustering and multidimensional scaling methods. New formula for estimating the fit of data to model, including the average percent standard deviation of distances on least squares trees, are presented. Use of edge-length vectors is compared and contrasted with correlated distance methods, correlated rates methods, and site-specific evidence of coevolution.
(40) Two siblings with epidermolysis bullosa
Authors: M.L. Wood, R.E. Church, M.E. Kesseler
Journal: British Journal of Dermatology (1986)

Journal Article (40) Two siblings with epidermolysis bullosa Get access M.L. Wood, Drs, M.L. Wood, Drs Search for other works by this author on: Oxford Academic Google Scholar R.E. Church, R.E. Church Search for other works by this author on: Oxford Academic Google Scholar M.E. Kesseler M.E. Kesseler Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s30, 1 July 1986, Page 85, https://doi.org/10.1111/j.1365-2133.1986.tb07735.x Published: 01 July 1986
Correlation between FDG/PET, histology, characteristics, and survival in 332 patients with chronic lymphoid leukemia
Authors: Lorenzo Falchi, Michael J. Keating, Edith M. Marom, Mylene T. Truong, Ellen J. Schlette, Rachel L. Sargent, Long Trinh, Xuemei Wang, Susan C. Smith, Nitin Jain, Zeev Estrov, Susan O’Brien, William G. Wierda, Susan Lerner, Alessandra Ferrajoli
Journal: Blood (2014)
Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart
Authors: Chantal Mercure, Alvaro Yogi, Glaucia E. Callera, Anna B. Aranha, Michael Bader, Anderson J. Ferreira, Robson A. S. Santos, Thomas Walther, Rhian M. Touyz, Timothy L. Reudelhuber
Journal: Circulation Research (2008)

Angiotensin-converting enzyme 2 (ACE2) converts the vasopressor angiotensin II (Ang II) into angiotensin (1-7) [Ang(1-7)], a peptide reported to have vasodilatory and cardioprotective properties. Inactivation of the ACE2 gene in mice has been reported by one group to result in an accumulation of Ang II in the heart and an age-related defect in cardiac contractility. A second study confirmed the role of ACE2 as an Ang II clearance enzyme but failed to reproduce the contractility defects previously reported in ACE2-deficient mice. The reasons for these differences are unclear but could include differences in the accumulation of Ang II or the deficiencies in Ang(1-7) in the mouse models used. As a result, the roles of ACE2, Ang II, and Ang(1-7) in the heart remain controversial. Using a novel strategy, we targeted the chronic overproduction of either Ang II or Ang(1-7) in the heart of transgenic mice and tested their effect on age-related contractility and on cardiac remodeling in response to a hypertensive challenge. We demonstrate that a chronic accumulation of Ang II in the heart does not result in cardiac contractility defects, even in older (8-month-old) mice. Likewise, transgenic animals with an 8-fold increase in Ang(1-7) peptide in the heart exhibited no differences in resting blood pressure or cardiac contractility as compared to age-matched controls, but they had significantly less ventricular hypertrophy and fibrosis than their nontransgenic littermates in response to a hypertensive challenge. Analysis of downstream signaling cascades demonstrates that cardiac Ang(1-7) selectively modulates some of the downstream signaling effectors of cardiac remodeling. These results suggest that Ang(1-7) can reduce hypertension-induced cardiac remodeling through a direct effect on the heart and raise the possibility that pathologies associated with ACE2 inactivation are mediated in part by a decrease in production of Ang(1-7).
Physical Activity Prevents Age-Related Impairment in Nitric Oxide Availability in Elderly Athletes
Authors: Stefano Taddei, Fabio Galetta, Agostino Virdis, Lorenzo Ghiadoni, Guido Salvetti, Ferdinando Franzoni, Costantino Giusti, Antonio Salvetti
Journal: Circulation (2000)

Background —Aging is associated with increased cardiovascular risk and endothelial dysfunction. Since exercise can improve endothelium-dependent vasodilation, in the present study we tested whether long-term physical activity could prevent aging-related endothelial dysfunction. Methods and Results —In 12 young and elderly (age 26.9±2.3 and 62.9±5.8 years, respectively) healthy sedentary subjects and 11 young and 14 elderly matched athletes (age 27.5±1.9 and 66.4±6.1 years, respectively), we studied (with strain-gauge plethysmography) forearm blood flow modifications induced by intrabrachial acetylcholine (0.15, 0.45, 1.5, 4.5, and 15 μg/100 mL per minute), an endothelium-dependent vasodilator, at baseline, during infusion of N G -monomethyl- l -arginine (L-NMMA) (100 μg/100 mL forearm tissue per minute), a nitric oxide–synthase inhibitor, vitamin C (8 mg/100 mL forearm tissue per minute), an antioxidant, and finally under simultaneous infusion of L-NMMA and vitamin C. The response to sodium nitroprusside (1, 2, and 4 μg/100 mL forearm tissue per minute) was also evaluated. In young athletes and sedentary subgroups, vasodilation to acetylcholine was inhibited by L-NMMA and was not changed by vitamin C. In elderly subjects, vasodilation to acetylcholine was blunted as compared with young subjects in both control subjects and athletes, whereas the response to sodium nitroprusside was similar. Moreover, in elderly athletes, vitamin C did not change the vasodilation to acetylcholine. In contrast, in elderly sedentary subjects, the response to acetylcholine was resistant to L-NMMA. In this subgroup, vitamin C increased the vasodilation to acetylcholine and restored the inhibiting effect of L-NMMA. Conclusions —These results suggest that regular physical activity can at least in part prevent the age-induced endothelial dysfunction, probably the restoration of nitric oxide availability consequent to prevention of production of oxidative stress.
The Rhesus and MN Blood Groups and Disease
Authors: A. S. Wiener
Journal: JAMA (1962)

ABSTRACT To the Editor:—  contribution by Buckwalter and G. V. Tweed on The Rhesus and MN Blood Groups and Disease, which appeared in  Journal (JAMA179:479 [Feb. 17] 1962) asserts that an association exists between the blood type N and rheumatic fever, and that individuals of particular Rh-Hr types are prone to duodenal and gastric ulceration, as well as to gastric carcinoma and rheumatic fever. These assertions can be challenged.Perusal of the tables suggests that a number of mistakes in blood grouping must have been made during this study, and, if this is true, this could have produced a bias in the results which created the illusion of the presence of various associations. As has been shown, in populations undergoing random intermarriage, the frequency of type MN cannot exceed 50%. Yet, in every study group by Buckwalter and Tweed, the frequency of type MN is significantly higher
Topical treatment of recurrent cutaneous leishmaniasis with ointment containing paromomycin and methylbenzethonium chloride.
Authors: J el-On, L Weinrauch, R Livshin, Z Even-Paz, G P Jacobs
Journal: BMJ (1985)

A propos de 2 observations. Resultats satisfaisants: amelioration clinique, disparition progressive des parasites et cicatrisation plus ou moins rapide: 85 j et 80 j respectivement. Le traitement est bien tolere et on n'observe pas de recidives (1 an de recul dans un cas)
Oral Application Of Bacterial Lysate In Infancy Decreases The Risk Of Infantile Atopic Eczema In A Subgroup Of Children With Paternal Atopy
Authors: S.G. Lau, K. Gerhold, C. Sulser, S. Rossberg, I. Witt, J. Wauer, J. Beschorner, R. Bunikowski, K. Zimmermann, G. Menke
Journal: Journal of Allergy and Clinical Immunology (2011)
Thrombin activatable fibrinolysis inhibitor activity, thrombin‐antithrombin complex and D‐dimer levels in preterm neonates with early respiratory distress syndrome
Authors: Tugba Gursoy, Gulsevin Tekinalp, Murat Yurdakok, Osman Ozcebe, Ayse Korkmaz, Aytemiz Gurgey
Journal: American Journal of Hematology (2007)

Abstract Intraalveolar fibrin deposition found in neonates with respiratory distress syndrome (RDS) is explained by the activation of the coagulation system and inefficient fibrinolysis. However, thrombin activatable fibrinolysis inhibitor activity (TAFIa), an inhibitor of fibrinolysis, and the ratio of D‐dimer to thrombin–antithrombin complex (D‐dimer/TAT), an index of fibrinolytic activity, have not been reported previously in neonatal RDS. Aim of this study is to evaluate the influence of plasma TAFIa levels on the fibrinolytic state in neonatal RDS. The RDS group (Group 1) consisted of 29 neonates, and 18 neonates served as the control group (Group 2). Plasma TAFIa levels and D‐dimer/TAT ratios were evaluated in all neonates in the first 6 hr of life. Neonates in the RDS group were further divided into two subgroups; Group 1a consisted of 12 neonates with evidence of mild asphyxia (Apgar score at 5 min &lt;7 and cord pH &lt;7.26), and Group 1b consisted of 17 nonasphyxiated neonates. No significant difference was found in TAFIa levels and D‐dimer/TAT ratios between Groups 1 and 2 [214% (56.2–361%) and 124.3 (4.4–3,921) in Group 1 and 201% (60.3–381%) and 147 (5.9–1,426) in Group 2]. There were negative correlations between cord pH and TAFIa levels in both groups. Increased TAFIa levels and decreased D‐dimer/TAT ratios and platelet counts were detected in mildly asphyxiated neonates when compared with nonasphyxiated ones. TAFIa is not responsible for the hypofibrinolytic state reported in RDS. However, asphyxia influences TAFIa levels and increased TAFIa levels depress fibrinolysis. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Are There Too Many US Transplantation Centers? Some Experts Suggest Fewer, Cheaper, and Better
Authors: Andrew A. Skolnick
Journal: JAMA (1994)

WHILE the increase in the number of transplantation centers across the United States may help provide easier and more equitable patient access to services, this growth is not always associated with good outcomes or with the most cost-effective use of donor organs and health care dollars. Such were the views a panel of experts presented at the first joint annual meeting, held in Washington, DC, of the United Network for Organ Sharing (UNOS) and the US Department of Health and Human Services' Division of Organ Transplantation. "Not everybody who wants a center can have one, and we better start to accept this at the outset of discussion," said panelist Charles M. Miller, MD, director of the liver transplant program at Mount Sinai Medical Center, New York, NY. Any hospital with at least one UNOS-approved transplantation program in association with an organ procurement officer and a tissue-typing laboratory can call itself
Abortion rates in England in 1995: comparative study of data from district health authorities
Authors: V. S. Raleigh
Journal: BMJ (1998)

pated in the first survey.Of the 13 respondents, 11 of whom had returned the previous survey, only two commented that population based data could be produced, while another two could supply hospital based datasets.The obstacles encountered by regional coordinators in providing data for 1993 and 1995 are given in the table.
Motorcycle and bicycle accidents.
Authors: K J Watson
Journal: BMJ (1979)

goods vehicles was more successful.It was followed by a marked decrease in deaths and injuries among occupants of goods vehicles-3700 fewer were killed in 1977 than in 1970.2In 1977 in magistrates courts in England and Wales 1-2 million persons were found guilty of motoring offences; of these 97°were fined.3Penalties for serious transgressions were too mild.In 82 480 driving licence offences, including driving while disqualified, a fine of £20 or less was imposed in 830oi, and £50 or less in 970°.In 7899 cases of dangerous driving the penalty was £50 or less in 51°', and £100 or less in 96o0.Fines must be increased if they are to remain a credible deterrent.Disqualification and penalties are ineffective in a small minority of habitual offenders, who often also have a past history of other criminal offences.These cases present a social as well as a legal problem.Adequate enforcement with suitable penalties can improve road behaviour, but the real answer is to persuade the public that traffic regulations are an essential ingredient of road safety.
Ogilvie's Syndrome During Chemotherapy With High-Dose Methotrexate for Primary CNS Lymphoma
Authors: Hao Xie, David M. Peereboom
Journal: Journal of Clinical Oncology (2012)

Case ReportA 70-year-old white woman was admitted to the hospital because of abdominal pain and diarrhea.Approximately 1 month before admission, the patient became confused, disoriented, and was found lying on the floor.She was admitted to another hospital.An examination revealed an unstable gait and a left homonymous hemianopsia.Magnetic resonance imaging of the brain revealed a 3-cm enhancing mass in the right temporal lobe.Computed tomography (CT) of the chest, abdomen, and pelvis was negative.A stereotactic brain biopsy proved the diagnosis of primary CNS lymphoma.An additional evaluation showed no intraocular or leptomeningeal involvement by lymphoma.Two weeks before admission, the patient began therapy on a clinical trial (Radiation Therapy Oncology Group 0227-rituximab, methotrexate, temozolomide, and whole-brain radiation therapy) and received rituximab 375 mg/m 2 intravenously (IV), which she tolerated well.Three days later she received high-dose methotrexate 3.5 g/m 2 IV with leucovorin.At the time of admission, the patient complained of fatigue, abdominal pain, and profuse diarrhea for 3 days.Her Karnofsky performance score was 50.Her past medical history included gastroesophageal reflux disease and hypertension, which were well managed by omeprazole and metoprolol, respectively.On physical examination, the patient appeared elderly and acutely ill.Her blood pressure was 121/71 mmHg, pulse was 96 beats/min, and temperature was 38.1°C.The abdominal examination was notable for abdominal distension and diffuse mild abdominal tenderness over all quadrants without rebound or flank tenderness.Laboratory tests revealed neutropenia with a neutrophil count of 210/L (reference range, Ͼ 1,500/ L), anemia with hemoglobin concentration of 9.7 g/dL (reference range, 12.0 to 16.0 g/dL), thrombocytopenia with a platelet count of 40 ϫ 10 3 /L (reference range, 150 to 350 ϫ 10 3 /L), and hypokalemia with potassium level of 3.1 mmol/L (reference range, 3.5 to 5.0 mmol/L).An abdominal CT was consistent with proctocolitis involving the descending colon, sigmoid, and rectum without evidence of perforation or fluid collection.On the basis of this clinical picture, the initial treatment included potassium chloride 20 mEq/dose IV every 1 hour for 4 hours, potassium chloride 40 mEq per day orally, piperacillin/tazobactam 3.375 g IV every 6 hours, and filgrastim 480 g subcutaneously per day.The pancytopenia and fever of the patient resolved by hospital day 6.However, her abdominal pain and distension worsened, and included bilateral lower back pain.She also had an episode of hematochezia.Abdominal CT showed the progression of proctocolitis with increased mesenteric and retroperitoneal edema as well as interval dilation of small and large bowels without evidence of obstruction, which was most consistent with ileus.The maximum colonic dilation
Hepatocyte transplant combined with nonparenchymal cells in the mesenteric fat pad in mouse
Authors: S NARUMI
Journal: Hepatology (1995)

Hepatoblastoma is the most frequent malignant pediatric liver tumor. Approximately 25% of hepatoblastoma patients cannot be cured with current treatment protocols. Additional treatment options must, therefore, be developed. Subcutaneous animal models for hepatoblastoma exist, but a more physiologic intrahepatic model is lacking.The α-fetoprotein-expressing hepatoblastoma-cell lines HepT1, HuH6 and the childhood hepatocellular carcinoma-cell line HepG2 were injected subcutaneously and intrasplenically into NMRI nu/nu mice. Tumor growth was monitored by measuring tumor size for subcutaneous and serum human α-fetoprotein levels for intra-abdominal tumors. Tumors were characterized microscopically.Subcutaneous tumor growth occurred in 70% (7/10) of mice injected with HuH6 and 50% (5/10) of mice injected with HepG2. HepT1 did not form tumors. Accumulation of serum α-fetoprotein reflected tumor growth. Intrasplenic growth was seen in 50% (14/27, HuH6) and 10% (3/10, HepG2) of the mice, with only HuH6 forming intrahepatic tumors in 25% (7/27) of the mice. Growth pattern and α-fetoprotein production were similar at the subcutaneous and intra-abdominal location. Intrahepatic grafting occurred by metastatic spread from the spleen, produced well-defined nodules, and was accompanied by a weakened expression of the hepatocyte marker carbamoylphosphate synthetase, and the canalicular markers CD10 and cytokeratin7. The expression of cytokeratin18 and -19, active caspase3, and β-catenin was increased. There were no lung metastases.We established an intrahepatic mouse model for human hepatoblastoma, in which tumor growth could be monitored by serum α-fetoprotein levels. Engrafting in the liver occurred by metastatic spread from the spleen and was accompanied by some loss of differentiation features.
CD40 inhibits replication of hepatitis C virus in primary human hepatocytes by c-jun N terminal kinase activation independent from the interferon pathway
Authors: Sibylle J. Rau, Eberhard Hildt, Kiyoshi Himmelsbach, Robert Thimme, Takaji Wakita, Hubert E. Blum, Richard Fischer
Journal: Hepatology (2012)

Abstract CD40, a member of the tumor necrosis factor receptor family, and its ligand, CD40L (CD154), are important regulators of the antiviral immune response. CD40L is up-regulated on lymphocytes and CD40 on hepatocytes during infection with hepatitis C virus (HCV); we investigated the role of CD40 signaling during HCV replication in hepatocytes. Viral replication was studied in primary human hepatocytes (PHH) and Huh7.5 cells using the infectious HCV Japanese fulminate hepatitis 1 isolate (JFH1) culture system, and in coculture with HCV antigen-specific CD8+ T cells. CD40L rapidly and transiently inhibits expression of the HCV nonstructural proteins NS3 and NS5A as well as HCV structural proteins core and E2 in Huh7.5 cells. Similarly, CD40L prevented replication of HCV in PHH, in synergy with interferon (IFN)-alpha. In Huh7.5 cells with replicating HCV, CD40L prevented production of infectious viral particles. When HCV antigen-specific CD8+ T cells were cocultured with HLA-A2-expressing Huh7 cells that had replicating virus, the T cells became activated, up-regulated CD40L, and inhibited HCV replication. Inhibition of CD40L partially prevented the antiviral activity of the CD8+ T cells. The antiviral effect of CD40L required activation of c-Jun N terminal kinases (JNK)1/2, but not induction of apoptosis or the JAK/STAT pathway that is necessary for the antiviral effects of IFNs. Conclusion: CD40 inhibits HCV replication by a novel, innate immune mechanism. This pathway might mediate viral clearance, and disruptions might be involved in the pathogenesis of HCV infection. (Hepatology 2013;)