Philadelphia Chromosome Abnormality in Agnogenic Myeloid Metaplasia
Authors: Ralph H. Forrester, Jose M. Louro
Journal: Annals of Internal Medicine (1966)

Case Studies1 March 1966Philadelphia Chromosome Abnormality in Agnogenic Myeloid MetaplasiaRALPH H. FORRESTER, JOSE M. LOURORALPH H. FORRESTERSearch for more papers by this author, JOSE M. LOUROSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-622 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1960, Nowell and Hungerford (1) described a chromosome change in chronic granulocytic leukemia which has since been confirmed by numerous workers and termed the Philadelphia chromosome (Ph1) abnormality. It consists of a loss either by deletion or translocation of approximately half of the genetic material occupying the long arms of one of the small acrocentric chromosomes. The change is illustrated schematically in Figure 1. Chromosome abnormalities of many types have been observed in leukemia (2, 3). There have been too many chromosomes, too few, and a variety of qualitative abnormalities (4). The Ph1has been unique in that it...References1. NOWELLHUNGERFORD PCDA: Minute chromosome in human chronic granulocytic leukemia. Science 132: 1497, 1960. Google Scholar2. FORDJACOBSLAJTHA CEPALG: Human somatic chromosomes. Nature (London) 181: 1565, 1958. CrossrefMedlineGoogle Scholar3. BAIKIECOURT BROWNJACOBSMILNE AGWMPAJS: Chromosome studies in human leukaemia. Lancet 2: 425, 1959. CrossrefMedlineGoogle Scholar4. GUNZFITZGERALD FWPH: Editorial: Chromosomes and leukemia. Blood 23: 394, 1964. CrossrefMedlineGoogle Scholar5. NOWELLHUNGERFORD PCDA: Chromosome studies in human leukemia. II Chronic granulocytic leukemia. J. Nat. Cancer Inst. 27: 1013, 1961. MedlineGoogle Scholar6. TOUGHCOURT BROWNBAIKIEBUCKTONHARNDENJACOBSKINGMCBRIDE IMWMAGKEDGPAMJJA: Cytogenetic studies in chronic myeloid leukaemia and acute leukaemia associated with mongolism. Lancet 1: 411, 1961. 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WALKER, M.D.Genetic Factors in CarcinomaTHE PHILADELPHIA CHROMOSOME AND LEUKOCYTE ALKALINE PHOSPHATASE IN CHRONIC MYELOCYTIC LEUKEMIA AND RELATED DISORDERSTHE PHILADELPHIA CHROMOSOME AND LEUKOCYTE ALKALINE PHOSPHATASE IN CHRONIC MYELOCYTIC LEUKEMIA AND RELATED DISORDERSHYPOGLYCÆMIC EFFECT OF TRIGONELLINESPECIFICITY OF THE Ph1 CHROMOSOME 1 March 1966Volume 64, Issue 3Page: 622-627KeywordsChromosomal translocationsChromosomesCytogeneticsGeneticsHospital medicinePhosphatases ePublished: 1 December 2008 Issue Published: 1 March 1966 PDF downloadLoading ...