Oligoclonal Immunoglobulins in Mastocytosis
Authors: WILLIAM J. MEGGS
Journal: Annals of Internal Medicine (1985)

Brief Reports1 December 1985Oligoclonal Immunoglobulins in MastocytosisWILLIAM J. MEGGS, M.D., Ph.D., MARIANNE FRIERI, M.D., Ph.D., RENE COSTELLO, B.S., DEAN D. METCALFE, M.D., NICHOLAS M. PAPADOPOULOS, Ph.D.WILLIAM J. MEGGS, M.D., Ph.D., MARIANNE FRIERI, M.D., Ph.D., RENE COSTELLO, B.S., DEAN D. METCALFE, M.D., NICHOLAS M. PAPADOPOULOS, Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-894 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMastocytosis is defined as a disease in which mast cells infiltrate one or more tissues. Mastocytosis may be either benign or malignant (1), with the benign form of the disease characterized by a protracted, indolent course. Persons with benign mastocytosis are at increased risk for developing hematologic malignancies and also a malignant form of mastocytosis (2, 3).The recognition of malignancy in mastocytosis may be difficult, as the signs of malignancy can be obscured by, or confused with, the abnormalities associated with benign mastocytosis. Because in recent studies oligoclonal immunoglobulins have been found in the sera of patients with certain malignancies...References1. SAGHEREVEN-PAZ FZ. Mastocytosis and the Mast Cell. Chicago: Year Book Medical Publishers, Inc. ; 1967:56. Google Scholar2. LENNERTPAWARESCH KM. Mast cell and mast cell neoplasia: a review. Histopathology. 1979;3:349-65. CrossrefMedlineGoogle Scholar3. ULTMANMUTTERTANNENBAUMWARNER JRMR. Clinical cytologic and biochemical studies on systemic mast cell diseases. Ann Intern Med. 1964;61:326-33. LinkGoogle Scholar4. PAPADOPOULOSELINWILSON NRD. The incidence of gammaglobulin banding in a healthy population by high-resolution electrophoresis. Clin Chem. 1982;28:707-8. CrossrefMedlineGoogle Scholar5. PAPADOPOULOSLANECOSTELLO NHR. Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome. Clin Immunol Immunopathol. 1985;35:43-6. CrossrefMedlineGoogle Scholar6. ROSENBAUMFRIERIMETCALFE RMD. Patterns of skeletal scintigraphy and their relationship to plasma and urinary histamine levels in systemic mastocytosis. J Nucl Med. 1984;25:859-64. MedlineGoogle Scholar7. MAGRATHBENJAMINPAPADOPOULOS IDN. Serum monoclonal immunoglobulin bands in undifferentiated lymphomas of Burkitt and non-Burkitt types. Blood. 1983;61:726-31. CrossrefMedlineGoogle Scholar8. YATES F. The analysis of contingency tables with groupings based on qualitative characters. Biometrika. 1948;35:176-81. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM J. MEGGS, M.D., Ph.D.; MARIANNE FRIERI, M.D., Ph.D.; RENE COSTELLO, B.S.; DEAN D. METCALFE, M.D.; NICHOLAS M. PAPADOPOULOS, Ph.D.Affiliations: National Institute of Allergy and Infectious Diseases, and the National Institutes of Health Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMastocytosisSystemic mastocytosis with plasma cell dyscrasia: Report of a caseSystemic MastocytosisTelangiectasia macularis eruptiva perstans and multiple myelomaClinical and Biologic Diversity of Leukemias Occurring in Patients with MastocytosisAcute nonlymphocytic leukemia in systemic mastocytosis with biclonal gammopathySystemic Mastocytosis: Retrospective Review of a Decade's Clinical Experience at the Brigham and Women's HospitalLymphadenopathic mastocytosis with eosinophilia and biclonal gammopathySkin diseases 1 December 1985Volume 103, Issue 6_Part_1Page: 894-895KeywordsCell physiologyHealth statisticsHematologic malignanciesImmunohistochemistryMast cellsMastocytosis ePublished: 1 December 2008 Issue Published: 1 December 1985 Copyright & Permissions©1985 American College of PhysiciansPDF downloadLoading ...