tbuckley/cabot-search huggingface dataset:
Methylprednisolone and Aplastic Anemia
Authors: Surapol Issaragrisil, Anong Painkijagum
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 December 1985Methylprednisolone and Aplastic AnemiaSURAPOL ISSARAGRISIL, M.D., ANONG PAINKIJAGUM, M.D., Ph.D.SURAPOL ISSARAGRISIL, M.D.Search for more papers by this author, ANONG PAINKIJAGUM, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-964_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Over the past decade, clinical and laboratory evidence has suggested that aplastic anemia is, in some patients, due to an "autoimmune mechanism," and interest has focused on the possibility of treating patients with immunosuppressive therapy (1). Antithymocyte globulin has been considered effective therapy for aplastic anemia in randomized control studies (2), but it is expensive and causes complications. Long-term bolus doses of methylprednisolone have been shown to induce hematologic recovery in such patients (3, 4). In our experience long-term treatment with methylprednisolone is usually associated with high morbidity and mortality due to infections. To avoid this complication,...References1. GLUCKMAN E, MARMONT A, SPECK B, and GORDON-SMITH E. Immunosuppressive treatment of aplastic anemia as an alternative treatment for bone marrow transplantation. Semin Hematol. 1984;21:11-19. MedlineGoogle Scholar2. CHAMPLIN R, HO W, and GALE R. Antithymocyte globulin treatment in patients with aplastic anemia. N Engl J Med. 1983;308:113-8. CrossrefMedlineGoogle Scholar3. BACIGALUPO A, GIOROANO D, VAN LINT M, VIMERCATI R, and MARMONT A. Bolus methylprednisolone in severe aplastic anemia [Letter]. N Engl J Med. 1979;300:501-2. CrossrefMedlineGoogle Scholar4. SANZ M, MARTINEZ J, BESALDUCH J, and RAFECAS J. Bolus of methylprednisolone for aplastic anemia [Letter]. Ann Intern Med. 1982;96:124. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SURAPOL ISSARAGRISIL, M.D.; ANONG PAINKIJAGUM, M.D., Ph.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced Blood DisordersRe-treatment of aplastic anemia with antithymocyte globulin or antilymphocyte serumSpecial Feature: New Therapies for Aplastic Anemia 1 December 1985Volume 103, Issue 6_Part_1Page: 964-964KeywordsAplastic anemiaClinical laboratoriesGlobulinsImmunosuppressivesMorbidityMortalityResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1985 PDF downloadLoading ...
Performance of a patient-dedicated, on-demand blood gas monitor in medical ICU patients.
Authors: C K Mahutte, S A Sasse, P A Chen, M Holody
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

We examined the performance characteristics of a new bedside blood gas monitor. This monitor's fluorescent pH, PCO2, and PO2 sensors are embedded in a cassette, which is calibrated in vitro and then inserted into the patient's radial artery tubing set. In 50 medical ICU patients, 683 paired monitor and conventional blood gas analyzer values were obtained. Performance was assessed via calculations of bias (mean monitor and analyzer difference) and its standard deviation (SD), plots of monitor and analyzer differences against the means (of monitor and analyzer), and linear regression analysis of the sequential changes in monitor values versus the corresponding sequential changes in analyzer values. The ex vivo calibration, assessed using the initial paired blood samples, showed a bias +/- SD of 0.02 +/- 0.02 for pH, -0.1 +/- 1.9 mm Hg for PCO2, and 4.3 +/- 6.0 mm Hg for PO2. For all paired samples (n = 683), the biases +/- SD were 0.004 +/- 0.023 for pH, 0.6 +/- 2.4 mm Hg for PCO2, and 2.7 +2- 6.4 mm HG for PO2. The PO2 bias increased as PO2 increased. The standard deviations (imprecision) of both PCO2 and PO2 also increased as the magnitudes of these variables increased. Sequential changes in monitor values versus the corresponding sequential changes in analyzer values revealed regression lines close to the line of identity. Serum sodium had no effect on pH bias. Daily drift of the sensors was inconsequential, with values of -0.01/d for pH, 1.7 mm Hg/d for PCO2, and 1.1 mm Hg/d for PO2. We conclude that the performance of this monitor is comparable to that of conventional blood gas analyzers.
Ultraviolet B exposure could influence the interpretation of serum S100? levels in patients with malignant melanoma
Authors: J. Vitzthum, H.D. Dörr, V. Meineke
Journal: British Journal of Dermatology (2007)

Journal Article Ultraviolet B exposure could influence the interpretation of serum S100β levels in patients with malignant melanoma Get access J. Vitzthum, J. Vitzthum Bundeswehr Institute of Radiobiology, Munich, Germany E‐mail: jannisvitzthum@bundeswehr.org Search for other works by this author on: Oxford Academic Google Scholar H.D. Dörr, H.D. Dörr Bundeswehr Institute of Radiobiology, Munich, Germany E‐mail: jannisvitzthum@bundeswehr.org Search for other works by this author on: Oxford Academic Google Scholar V. Meineke V. Meineke Bundeswehr Institute of Radiobiology, Munich, Germany E‐mail: jannisvitzthum@bundeswehr.org Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 4, 1 April 2007, Pages 772–773, https://doi.org/10.1111/j.1365-2133.2006.07737.x Published: 01 April 2007
Etiology and Prevalence of Hypertension in Diabetic Patients
Authors: Donald C Simonson
Journal: Diabetes Care (1988)

Data from several epidemiologic studies have suggested that the prevalence of hypertension in patients with diabetes mellitus is ∼1.5–2.0 times greater than in an appropriately matched nondiabetic population. In patients with insulin-dependent diabetes mellitus (IDDM), hypertension is generally not present at the time of diagnosis. As renal insufficiency develops, blood pressure rises and may exacerbate the progression to end-stage renal failure. In non-insulin-dependent diabetes mellitus (NIDDM), many patients are hypertensive at the time of diagnosis. The incidence of hypertension in NIDDM is related to the degree of obesity, advanced age, and extensive atherosclerosis that is typically present, and it probably includes many patients with essential hypertension. Several other pathophysiologic mechanisms also contribute to the genesis and maintenance of hypertension in the patient with diabetes. Hyperglycemia and increases in totalbody exchangeable sodium may lead to extracellular fluid accumulation and expansion of the plasma volume. In some patients, alterations in the function of the renin-angiotensin-aldosterone system and vascular sensitivity to vasoactive hormones may also play a role. It has recently been suggested that hyperinsulinemia and insulin resistance may also contribute to the maintenance of an elevated blood pressure because insulin is known to promote sodium retention and enhance sympathetic nervous system activity. The evidence for these hypotheses and their respective contributions to the etiology of hypertension in IDDM and NIDDM are discussed.
Regret and justification as a link from argumentation to consequentialism
Authors: Terry Connolly, Jochen Reb
Journal: Behavioral and Brain Sciences (2011)

Abstract Mercier and Sperber (M&amp;S) argue that reasoning has evolved primarily as an adjunct to persuasive communication rather than as a basis for consequential choice. Recent research on decision-related regret suggests that regret aversion and concomitant needs for justification may underpin a complementary mechanism that can, if appropriately deployed, convert M&amp;S's facile arguer into an effective decision maker, with obvious evolutionary advantages.
Studies on a family with combined functional deficiencies of vitamin K-dependent coagulation factors.
Authors: G H Goldsmith, R E Pence, O D Ratnoff, D J Adelstein, B Furie
Journal: Journal of Clinical Investigation (1982)

Two siblings with m ild hemorrhagic symptoms had combined functional deficiencies of vitamin K-dependent clotting factors. Prothrombin (0.18-0.20 U/ml) and Stuart factor (Factor X, 0.18-0.20 U/ml) and Stuart factor (Factor X, 0.18-0.20 U/ml) were most severely affected. Antigenic amounts of affected coagulation factors were normal and normal generation of thrombin activity occurred in the patients' plasmas after treatment with nonophysiologic activators that do not require calcium for prothrombin activation. Hepatobilary disease, malabsorptive disorders, and plasma warfarin were not present. Both parents had normal levels of all coagulation factors. The patients' plasmas contained prothrombin that reacted both with antibody directed against des-gamma-carboxyprothrombin and native prothrombin. Crossed immunoelectrophoresis of patients' plasmas and studies of partially purified patient prothrombin suggested the presence of a relatively homogeneous species of dysfunctional prothrombin, distinct from the heterologous species found in the plasma of warfarin-treated persons. These studies are most consistent with a posttranslational defect in hepatic carboxylation of vitamin K-dependent factors. This kindred uniquely possesses an autosomal recessive disorder of vitamin K-dependent factor formation that causes production of an apparently homogeneous species of dysfunctional prothrombin; the functional deficiencies in clotting factors are totally corrected by oral or parenteral administration of vitamin K1.
Common Market--a Challenge, Not a Danger
Authors: S. R. Scagliola
Journal: BMJ (1967)

Council about the implica- tions for the British medical profession of United Kingdom entry into the European Economic Community (Supplement, 13 May, p. 85) Dr. Derek Stevenson said that " the General Medical Council was fully alive to the dangers that faced doctors if Britain entered the Common Market," and later Dr.A
Minocycline Treatment of Pulmonary Nocardiosis
Authors: Eskild A. Petersen
Journal: JAMA (1983)

Minocycline hydrochloride was used to treat pulmonary infections with<i>Nocardia asteroides</i>in five cardiac allograft recipients. In three patients, minocycline was successfully used as the only antinocardial agent. Two other patients were found to have leukopenia after initial therapy with sulfisoxazole. These two patients were subsequently treated with minocycline. The clinical success with minocycline in these highly immunosuppressed patients suggests that minocycline is an effective antinocardial agent. These data did not allow any conclusion regarding which drug, minocycline or sulfisoxazole, is superior in the treatment of this disease. (<i>JAMA</i>1983;250:930-932)
615 Treatment comparison of patients with chronic hepatitis C and elevated ALT vs patients with persistently normal ALT — preliminary results of a prospective open trial
Authors: W. Vogel, H. Brunner, M. Rosenbeiger, I. Graziadei, A. Maieron, K. Jilek, R. Stauber, D. Wolkersdorfer, H. Ulmer
Journal: Journal of Hepatology (2006)
Early research says dust at World Trade Center site not dangerous
Authors: Janice Hopkins Tanne
Journal: BMJ (2001)

Environment specialists told New York workers and residents last week that early studies of asbestos and lead levels in the dust at the site of the collapsed World Trade Center showed that they were below danger levels.

The specialists also described some studies that are going to be carried out to follow the affected population. The studies will involve two child health centres at Columbia University and Mt Sinai Medical Centre and four environmental health centres at Columbia University, New York University, the University of Medicine and Dentistry of New Jersey, and Johns Hopkins University in Baltimore.

The experts addressed a community meeting last week of more than 200 people at a …
Vaccines for HIV infected pregnant women?
Authors: D Nixon
Journal: BMJ (1991)

RiskfactorsforacquiringHIVinfection among 75 women Risk factors No Injecting drug misuse 24 Blood transfusions in Africa 2 Sexual partner an intravenous drug misuser 5 Sexual partner bisexual 2 Sexual partner or partners abroad 40 Under investigation 2arrived in the United Kingdom; three (one Australian and two British) had been sexually assaulted abroad; and the remaining three (two British and one Dutch) had had partners abroad - one from central Africa, one from the United States, and one from Holland.Thirty nine of the 40 women first attended these hospitals after the beginning of 1989, and 35 had acquired the infection during heterosexual contact in Africa.This study supports the contention that most female patients infected with HIV during heterosexual contact who attend departments of genitourinary medicine were infected in Africa and imported the infection into the United Kingdom.Further efforts to identify and help such patients must use this knowledge.
Abstract 1050: Alvespimycin (17-DMAG) blocks TGFβ-induced EMT and migration in A549 lung cancer cells
Authors: Edna Gordian, Eric Welsh, Teresita Muñoz-Antonia
Journal: Cancer Research (2014)

Abstract Background: Transforming Growth Factor β (TGFβ) can induce Epithelial-to-Messenchymal Transition (EMT) in Non-Small Cell Lung Cancer (NSCLC) leading to increased potential to migrate and metastasize. A unique Tumor Promoting signature (TGFβ-TP97) with genes highly associated with TGFβ-induced EMT was derived from human lung cancer cell line microarray experiments. The TGFβ-TP97 EMT signature was then searched against the Connectivity Map (CMAP) dataset for drugs that induce gene expression changes opposite to those of the TGFβ-TP97 signature, and identified 17-DMAG as a compound that could potentially inhibit EMT in NSCLC cells. 17-DMAG is an Hsp90 inhibitor recently described to have a stronger antiproliferative effect in NSCLC harboring EGFR mutations over EGFR wild type lung cancers cells. Furthermore, 17-DMAG has been recently shown to prevent TGFβ induced fibrosis. Methods: A549 and A549T (A549 cells grown in the presence of TGFβ for over two weeks, that have acquired a mesenchymal/fibroblast-like phenotype) were treated with increasing concentrations of 17-DMAG, both in the absence and presence of 5ng/mL TGFβ, and proliferation was measured through GLO assay after 72 hours. The effects of 17-DMAG on TGFβ signaling was tested by Western Blotting for phosphorylated Smads and markers of TGFβ-induced EMT. 17-DMAG effects on morphology and migration were also determined through wound healing and invasion assays. Results: 1) A549T cells grown in TGFβ are more sensitive to the effects of 17-DMAG than cells grown without TGFβ; 2) Pre-treatment of A549 cells with 17-DMAG blocks the induction of EMT markers such as Snail and the downregulation of Ecadherin; 3) 17-DMAG blocks TGFβ-induced phosphorylation of SMAD2, SMAD3; and 4) 17-DMAG inhibits migration and decreases motility of A549 cells in the presence of TGFβ. Conclusion: These results show that 17-DMAG is a potent inhibitor of the effects of TGFβ-induced EMT in A549 cells. It interferes with the regulated process of TGFβ signaling by its ability to block Smad activation and induction of EMT proteins. These findings suggest that 17-DMAG can potentially be used in the treatment of NSCLC cells to prevent disease dissemination and invasion. Citation Format: Edna Gordian, Eric Welsh, Teresita Muñoz-Antonia. Alvespimycin (17-DMAG) blocks TGFβ-induced EMT and migration in A549 lung cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1050. doi:10.1158/1538-7445.AM2014-1050
Studies Probe Oral Health–Diabetes Link
Authors: Tracy Hampton
Journal: JAMA (2008)

PHYSICIANS AND DENTISTS HAVE long known that the health of an individual’s mouth can have significant effects on the health of the rest of the body. The link between periodontal disease and heart disease is one of the most commonly known associations, but researchers are finding many more medical reasons to maintain good oral hygiene. Diabetes, the focus of much attention lately due to its rising incidence, appears to have a particularly close relationship with conditions within the oral cavity. This relationship seems to go both ways—diabetes can lead to unwanted changes in the gums and periodontal tissues, and periodontal diseases—including gingivitis and severe periodontitis— can make it more difficult to control diabetes.
Growth Differentiation Factor 15: A Novel Risk Marker Adjunct to the EuroSCORE for Risk Stratification in Cardiac Surgery Patients
Authors: Matthias Heringlake, Efstratios I. Charitos, Nicola Gatz, Jan-Hendrik Käbler, Anna Beilharz, Daniel Holz, Julika Schön, Hauke Paarmann, Michael Petersen, Thorsten Hanke
Journal: Journal of the American College of Cardiology (2013)
&lt;emph type="ital"&gt;Bust of Marsyas&lt;/emph&gt;
Authors: Thomas B. Cole
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Type III Hyperlipoproteinemia: Diagnosis in Whole Plasma by Apolipoprotein-E Immunoassay
Authors: RAMPRATAP S. KUSHWAHA
Journal: Annals of Internal Medicine (1977)

Because the cholesterol-rich very low density (VLD) lipoproteins of subjects with type III hyperlipoproteinemia are distinctively enriched in apolipoprotein E, a radial immunodiffusion assay for apolipoprotein E in whole plasma was developed. Its diagnostic usefulness was tested in randomly selected (n = 174) and hyperlipidemic (n = 61) subsets of an adult employee population and a hyperlipidemia clinic referral group (n = 63), which included 18 patients with well-documented type III hyperlipoproteinemia. Apolipoprotein-E levels were normally distributed among the random population subset, were equal between the two sexes, and increased little with age. The mean and 99th percentile values were 24.6 and 40.1 mg/dl, respectively. All subjects with type III patterns as assigned by standard criteria from both population (n = 4) and referral sources exceeded this 99th percentile (chi +/- SD = 54.7 +/- 9.7 mg/dl). Hence a plasma apolipoprotein-E concentration exceeding 40 mg/dl appears diagnostic of type III hyperlipoproteinemia, representing the first application of an apolipoprotein immunoassay to improved diagnosis of the hyperlipoproteinemias.
Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells
Authors: Ming Luo, Huaping Fan, Tamas Nagy, Huijun Wei, Chenran Wang, Suling Liu, Max S. Wicha, Jun-Lin Guan
Journal: Cancer Research (2009)

Abstract Focal adhesion kinase (FAK) has been implicated in the development of cancers, including those of the breast. Nevertheless, the molecular and cellular mechanisms by which FAK promotes mammary tumorigenesis in vivo are not well understood. Here, we show that targeted deletion of FAK in mouse mammary epithelium significantly suppresses mammary tumorigenesis in a well-characterized breast cancer model. Ablation of FAK leads to the depletion of a subset of bipotent cells in the tumor that express both luminal marker keratin 8/18 and basal marker keratin 5. Using mammary stem/progenitor markers, including aldehyde dehydrogenase, CD24, CD29, and CD61, we further revealed that ablation of FAK reduced the pool of cancer stem/progenitor cells in primary tumors of FAK-targeted mice and impaired their self-renewal and migration in vitro. Finally, through transplantation in NOD-SCID mice, we found that cancer stem/progenitor cells isolated from FAK-targeted mice have compromised tumorigenicity and impaired maintenance in vivo. Together, these results show a novel function of FAK in maintaining the mammary cancer stem/progenitor cell population and provide a novel mechanism by which FAK may promote breast cancer development and progression. [Cancer Res 2009;69(2):466–74]