tbuckley/cabot-search huggingface dataset:
Electrophysiologic Properties of Diphenylhydantoin
Authors: ANTHONY R. CARACTA, ANTHONY N. DAMATO, MARK E. JOSEPHSON, MICHAEL A. RICCIUTTI, JOHN J. GALLAGHER, SUN H. LAU
Journal: Circulation (1973)

The electrophysiologic properties of diphenylhydantoin (DPH) (5-10 mg/kg) intravenously was studied in 14 subjects using His bundle recordings and correlated with blood levels. Conduction through the A-V conducting system (AVCS) was studied at various paced atrial rates and refractory periods determined using programmed atrial premature depolarization within 10 min of drug administration. In 11 of 14 subjects the sinus cycle length was shortened by an average of 110 msec, lengthened in three (average 116 msec). Conduction through the A-V node (AVN) was shortened in seven subjects (average 10 msec), lengthened in one (5 msec), and unchanged in the remaining six. Conductinged by 5 msec). Prior to DPH, the longest mained constant in all but two subjects (proloengthened in four, and was unchanged in the re-refractory period of the AVCS was in the AVN in nine subjects, the atrium in four and the HPS in one. After DPH, the following effects were noted: (1) the effective refractory period (ERP) of the atria shortened in four subjects, lengthened in four, and was unchanged in the remaining six; (2) the ERP of the AVN shortened in 6/9 subjects, lengthened in 3/9; (3) functional refractory period of AVN shortened in six, prolonged in three subjects, and remained unchanged in five subjects; (4) the relative refractory period (RRP) of the HPS shortened in 7/7 subjects; (5) ERP of HPS in 1/1 subject shortened. Thus, DPH showed varied effects on A-V nodal conduction, inconsistent effect in the atrium, and consistent shortening of the refractory period of the HPS. The data suggest DPH differs from other antiarrhythmic drugs such as quinidine and procaine amide.
AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts
Authors: Jing Zhang, Serk In Park, Marlene C. Artime, Justin M. Summy, Ami N. Shah, Joshua A. Bomser, Andrea Dorfleutner, Daniel C. Flynn, Gary E. Gallick
Journal: Journal of Clinical Investigation (2007)

The actin filament–associated protein AFAP-110 is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP-110 regulates actin cytoskeleton integrity but also functions as an adaptor protein that affects crosstalk between Src and PKC. Here we investigated the roles of AFAP-110 in the tumorigenic process of prostate carcinoma. Using immunohistochemistry of human tissue arrays, we found that AFAP-110 was absent or expressed at very low levels in normal prostatic epithelium and benign prostatic hyperplasia but significantly increased in prostate carcinomas. The level of AFAP-110 in carcinomas correlated with the Gleason scores. Downregulation of AFAP-110 in PC3 prostate cancer cells inhibited cell proliferation in vitro and tumorigenicity and growth in orthotopic nude mouse models. Furthermore, downmodulation of AFAP-110 resulted in decreased cell-matrix adhesion and cell migration, defective focal adhesions, and reduced integrin β1 expression. Reintroduction of avian AFAP-110 or a mutant disabling its interaction with Src restored these properties. However, expression of an AFAP-110 lacking the PKC-interacting domain failed to restore properties of parental cells. Thus, increased expression of AFAP-110 is associated with progressive stages of prostate cancer and is critical for tumorigenic growth, in part by regulating focal contacts in a PKC-dependent mechanism.
A new capsule endoscopy feature of serosal eosinophilic enteritis
Authors: A. Koumi, M. Panos
Journal: Endoscopy (2009)

A 37-year-old woman presented with intermittent, colicky abdominal pain, vomiting, and abdominal distension since the past 20 days. There was no history of fever, diarrhea, or blood or mucus in the stool. The abdomen was slightly distended but not tender, and bowel sounds were normal. Blood tests revealed eosinophilia (white blood cell [WBC] count 11.6 × 109/L, eosinophils 3.6 × 109/L) and serum albumin was 0.4 g/L. Stool cultures and a parasitological examination were negative.
1053 A NOVEL SYNTHETIC SULFOGLYCOLIPID SULFOQUINOVOSYLACYL PROPANEDIOL (SQAP) SWITCHES OFF TUMOR ANGIOGENIC POTENTIAL OF HEPATOCELLULAR CARCINOMA THROUGH THE UPREGULATION OF VON HIPPEL–LINDAU PROTEIN
Authors: H. Iwamoto, T. Torimura, K. Ohta, H. Koga, T. Nakamura, M. Abe, H. Masuda, H. Yano, M. Sata
Journal: Journal of Hepatology (2013)
STUDIES ON THE INTERACTIONS BETWEEN COMPONENTS OF STAPHYLOCOCCUS AUREUS AND STAPHYLOCOCCUS BACTERIOPHAGE
Authors: Stephen I. Morse
Journal: The Journal of Experimental Medicine (1962)

The cell walls of Staphylococcus aureus are capable of inactivating S. aureus bacteriophage. Furthermore, the cell walls isolated from S. aureus of a given phage type inactivate a variety of different staphylococcal bacteriophages. Under the conditions employed neither the isolated mucopeptide nor teichoic acid components of the cell walls act as bacteriophage receptor.
Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease
Authors: Franziska Jundt, Katharina Kley, Ioannis Anagnostopoulos, Kristina Schulze Pröbsting, Axel Greiner, Stephan Mathas, Claus Scheidereit, Thomas Wirth, Harald Stein, Bernd Dörken
Journal: Blood (2002)
Understanding influences on smoking in Bangladeshi and Pakistani adults: community based, qualitative study
Authors: J. Bush
Journal: BMJ (2003)

<h3>Abstract</h3> <b>Objective:</b> To gain detailed understanding of influences on smoking behaviour in Bangladeshi and Pakistani communities in the United Kingdom to inform the development of effective and culturally acceptable smoking cessation interventions. <b>Design:</b> Qualitative study using community participatory methods, purposeful sampling, one to one interviews, focus groups, and a grounded approach to data generation and analysis. <b>Setting:</b> Newcastle upon Tyne, during 2000-2. <b>Participants:</b> 87 men and 54 women aged 18–80 years, smokers and non-smokers, from the Bangladeshi and Pakistani communities. <b>Results:</b> Four dominant, highly inter-related themes had an important influence on smoking attitudes and behaviour: gender, age, religion, and tradition. Smoking was a widely accepted practice in Pakistani, and particularly Bangladeshi, men and was associated with socialising, sharing, and male identity. Among women, smoking was associated with stigma and shame. Smoking in women is often hidden from family members. Peer pressure was an important influence on smoking behaviour in younger people, who tended to hide their smoking from elders. There were varied and conflicting interpretations of how acceptable smoking is within the Muslim religion. Tradition, culture, and the family played an important role in nurturing and cultivating norms and values around smoking. <b>Conclusion:</b> Although there are some culturally specific contexts for smoking behaviour in Bangladeshi and Pakistani adults—notably the influence of gender and religion—there are also strong similarities with white people, particularly among younger adults. Themes identified should help to inform the development and appropriate targeting of smoking cessation interventions. <h3>What is already known on this topic</h3> Smoking is common among Bangladeshi and Pakistani men in Britain but rare among the women Smoking is particularly common in Bangladeshi men Socioeconomic status is thought to influence smoking uptake in Bangladeshi men Influences on smoking in South Asians in Britain are poorly understood <h3>What this study adds</h3> Smoking among Pakistani and Bangladeshi men is strongly seen as socially acceptable—a "normal" part of being a man Smoking in Bangladeshi men is more deeply socially ingrained than in Pakistanis, contributing to group cohesion and identity Smoking in Bangladeshi and Pakistani women is associated with a strong sense of cultural taboo, stigma, and non-acceptance Islam forbids addiction and intoxicants, but opinions differ on whether the Muslim religion allows smoking Culturally sensitive smoking cessation interventions for Bangladeshis and Pakistanis are needed
Cutaneous Immunologic Reactions to Hepatitis B Virus Vaccine
Authors: Francesco Drago, Alfredo Rebora
Journal: Annals of Internal Medicine (2002)

Letters21 May 2002Cutaneous Immunologic Reactions to Hepatitis B Virus VaccineFrancesco Drago, MD and Alfredo Rebora, MDFrancesco Drago, MDUniversity of Genoa; 16132 Genoa, Italy (Drago, Rebora) and Alfredo Rebora, MDUniversity of Genoa; 16132 Genoa, Italy (Drago, Rebora)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-10-200205210-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the letter by Geier and Geier about the risk for immunologic reactions after hepatitis B virus (HBV) vaccine (1). The authors did not mention dermatologic side effects that are intensely immunologic and that may throw light on the pathogenetic mechanisms of immunologic reactions to HBV vaccine.Lichen planus–like reactions are well known (2) and since 1993 have been listed as a side effect of HBV vaccines (3). Their clinical presentation and epidemiology may help explain why they occur in vaccine recipients.In lichen planus eruptions, the primary lesions are flat-topped erythemato-violaceous papules that ...References1. Geier MR, Geier DA. Immunologic reactions and hepatitis B vaccine [Letter]. Ann Intern Med. 2001;134:1155. [PMID: 11412070] LinkGoogle Scholar2. Ciaccio M, Rebora A. Lichen planus following HBV vaccination: a coincidence? [Letter]. Br J Dermatol. 1990;122:424. [PMID: 2138913] CrossrefMedlineGoogle Scholar3. Martindale W, Williams JE. The Extra Pharmacopoeia. 30th ed. London: Pharmaceutical Pr; 1993:1238. Google Scholar4. Rebora A, Rongioletti F, Drago F, Parodi . Lichen planus as a side effect of HBV vaccination [Editorial]. Dermatology. 1999;198:1-2. [PMID: 10200042] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Genoa; 16132 Genoa, Italy (Drago, Rebora) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImmunologic Reactions and Hepatitis B Vaccine Mark R. Geier and David A. Geier Cutaneous Immunologic Reactions to Hepatitis B Virus Vaccine David A. Geier and Mark R. Geier Metrics Cited byDrug ReactionsTwo case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulare 21 May 2002Volume 136, Issue 10Page: 780KeywordsAntigensApoptosisClinical epidemiologyCytotoxic T cellsHepatitis B virusImmune system proteinsKeratinocytesPathogensRecombinant proteinsVaccines ePublished: 21 May 2002 Issue Published: 21 May 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Predicting Outcome by Images?
Authors: Dirk De Ruysscher
Journal: Clinical Cancer Research (2013)

Features from CT, MRI, and PET scans are related to survival of patients with non-small cell lung carcinoma. Individualized image-based tissue characterization allows a whole body view of all tumor deposits and organs at risk. The time is ripe to embark on huge international studies aiming to validate and implement this technology in clinical practice.
Local INR control had some effect on the benefits of dabigatran over warfarin for major bleeding in atrial fibrillation
Authors: Stacy Johnson, Matthew Rondina
Journal: Annals of Internal Medicine (2011)

Source Citation Wallentin L, Yusuf S, Ezekowitz MD, et al. Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Lancet. 2010;376:975-83. 20801496
Why do patients with lupus nephritis die?
Authors: P Correia, J S Cameron, J D Lian, J Hicks, C S Ogg, D G Williams, C Chantler, D G Haycock
Journal: BMJ (1985)

Over 20 years 42 of 138 patients with systemic lupus erythematosus "died"--that is, suffered actual death or went into terminal renal failure, or both; data from 41 were available for analysis. In most patients the causes of death were multiple. Twenty seven patients went into terminal renal failure, of whom 25 were offered dialysis treatment. Three regained renal function later, 12 survived on dialysis or with functioning kidney allografts--almost all with inactive lupus--but 13 died after starting dialysis, most within a few weeks or months. The principal causes were active lupus or infection. In those patients with renal failure after rapid deterioration in renal function (n = 14) there were nine deaths, while of 10 patients with a slow evolution into renal failure, only four died. Four patients with impaired and 10 with normal renal function died, again most often from complications of lupus or from infection. Vascular disease was a major cause of death in seven patients, all but two of whom were young; of 15 postmortem examinations, eight showed severe coronary artery atheroma, and three surviving patients required coronary bypass operations. Analysis of the timing of death or entry into renal failure showed that in 12 out of 13 patients who died within two years of onset the lupus was judged to be active, while this was true in only eight out of 19 patients who died later. Six of the seven vascular deaths occurred later than two years from onset, while only nine of 26 renal "deaths" occurred before two years; deaths from infections (n = 13) were distributed equally. Despite this and aggressive treatment of active disease, the principal cause of actual death was uncontrolled lupus.
THREE CASES OF LICHEN PLANUS IN CHILDREN
Authors: H.G. ADAMSON
Journal: British Journal of Dermatology (1920)

LICHEN PLANUS is not often seen in young children.Dr. Colcott Fox described, in the British Journal of Dennatologij, in 1891, "an acute generalised Lichen planus in infants."But he afterwards admitted that these cases were reallv a form of Lichen urticatus in which the fading papules had acquired a flat-topped shiny aspect and not true Lichen planus.In 1900^ in a discussion on Lichen planus, he said : "My riper experience goes to show that I have never seen true Lichen planus in an infant."On searching the literature of Lichen planus I am able to'find references to four cases only of true Lichen planus in young children.Crocker mentions a case seen by Kaposi in a child aged 8 months, and one by Hallopeau in a child aged 12 months.He also records a case of linear Lichen planus in a girl aged 12 years.Macleod, in 1907, showed a little gir], aged 8 years, who had Lichen planus et pilaris.The following three cases of Lichen planus in young children have come under my own observation: VOL.XXXII.B
Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody.
Authors: V T Lombardo, E Hodson, J R Roberts, T J Kunicki, T S Zimmerman, Z M Ruggeri
Journal: Journal of Clinical Investigation (1985)

In this study we have used two new monoclonal antibodies, designated LJP5 and LJP9, as well as a previously described one, AP2, all specific for the platelet membrane glycoprotein (GP)IIb/IIIa complex. None of them reacted with dissociated GPIIb or GPIIIa. The monovalent Fab fragment of both LJP5 and LJP9 bound to unstimulated platelets in a saturable manner, but binding was markedly decreased after platelets had been incubated at 37 degrees C in the absence of added extracellular calcium. The binding of LJP9 was not affected by AP2, but was blocked by excess LJP5. On the contrary, the binding of LJP5 was blocked in the presence of both AP2 and LJP9. Thus, these antibodies bound to distinct epitopes of GPIIb/IIIa. At saturation, the binding to unstimulated platelets was between 2.41 and 10.9 X 10(4) molecules/platelet for LJP5 and between 3.47 and 9.1 X 10(4) molecules/platelet for LJP9 (range of 11 and 10 experiments, respectively). Binding increased up to 50% after thrombin stimulation. The estimated association constant, Ka, was 2.7 X 10(7) M-1 for LJP5 and 3.85 X 10(7) M-1 for LJP9. Both LJP5 and LJP9 partially inhibited the association of 45Ca2+ with the surface of unstimulated platelets. Moreover, both antibodies blocked the binding of von Willebrand factor (vWF) to stimulated platelets, whereas only LJP9, but not LJP5, blocked fibrinogen binding. LJP9 was also a potent inhibitor of platelet aggregation, whereas LJP5 was without effect in this regard. The results of the present study demonstrate that independent modulation of vWF and fibrinogen binding to stimulated platelets can be attained with monoclonal antibodies directed against distinct epitopes of GPIIb/IIIa.
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
Authors: Martin E Hess, Simon Hess, Kate D Meyer, Linda A W Verhagen, Linda Koch, Hella S Brönneke, Marcelo O Dietrich, Sabine D Jordan, Yogesh Saletore, Olivier Elemento, Bengt F Belgardt, Thomas Franz, Tamas L Horvath, Ulrich Rüther, Samie R Jaffrey, Peter Kloppenburg, Jens C Brüning
Journal: Nature Neuroscience (2013)
Decreased 19S antibody response to bacterial antigens in systemic lupus erythematosus
Authors: John Baum, Morris Ziff
Journal: Journal of Clinical Investigation (1969)

The antibody response to immunization with Brucella and the levels of natural antibody to Escherichia coli and Shigella were compared in patients with systemic lupus erythematosus and control groups. After Brucella immunization, SLE patients showed a significantly lower antibody response in whole serum and in the macroglobulin antibody fraction separated by sucrose density gradient centrifugation. Sucrose gradient fractionation of natural antibodies to E. coli and a polyvalent Shigella antigen showed a significant decrease in macroglobulin antibody against four of the five E. coli antigens tested and the Shigella polyvalent antigen in SLE patients when compared with a group of normal individuals and a matched control group with pulmonary tuberculosis. Whole serum natural antibody titers against 5 of 13 Shigella antigens were significantly lower in the SLE patients when compared with the normal group, and against 7 of 13 when compared with the matched tuberculosis controls. Whole serum titers against 8 of 13 E. coli antigens were significantly lower in the SLE patients when compared with normal subjects. The observed decreased antibody response to bacterial antigens in SLE patients, occurring mainly in the macroglobulin fraction, is discussed in relation to the increased incidence of infection commonly observed in these patients.
Paget Disease of the Humerus Mimicking Metastatic Disease in a Patient With Metastatic Malignant Mesothelioma on Whole Body F-18 FDG PET/CT
Authors: Syed Mahmood, Sofia R. Martinez de Llano
Journal: Clinical Nuclear Medicine (2008)

A 71-year-old man with newly diagnosed malignant mesothelioma was referred for an F-18 FDG PET/CT study to evaluate the extent of disease. PET showed mild FDG uptake in the right chest, corresponding to a lobulated, mass-like right pleural effusion versus thickening involving the entire right pleural space, and some mediastinal involvement, on the accompanying CT scan. In addition, marked FDG uptake was seen in the proximal left humerus, suspicious for an osseous metastasis. The corresponding CT scan findings of cortical thickening and a “Swiss cheese” appearance were most consistent with Paget disease. The intense FDG uptake in an osseous lesion on FDG-PET in our case reminds us of the variable nature of FDG uptake in Paget disease, the possibility of false-positive findings on FDG-PET in patients with cancer, and the usefulness of the fusion techniques in the evaluation of skeletal lesions, with the potential for discriminating between benign Paget disease and other pathologic bone findings.
Migration of a Phthalate Ester Plasticizer from Polyvinyl Chloride Blood Bags into Stored Human Blood and Its Localization in Human Tissues
Authors: Rudolph J. Jaeger, Robert J. Rubin
Journal: New England Journal of Medicine (1972)

A plasticizer, di-2-ethylhexyl phthalate, was found to be extracted from polyvinyl chloride plastic blood bags by both human and dog blood stored at 4°C at a rate of 0.25 ± 0.03 mg per 100 ml per day. Plasticizer was found in both the lipid-containing and lipid-free fractions of plasma whereas red cells contained only minor amounts. Seven of 12 lung-tissue samples taken at autopsy from patients who had received transfusions of stored blood contained detectable amounts of plasticizer. One patient, after open-heart surgery, excreted a urinary metabolite of the plasticizer in excess of the amount calculated to have been received in the transfused blood. The additional metabolite possibly came from plasticizer extracted from the polyvinyl chloride tubing of the cardiopulmonary unit. Although the toxicologic implications of these observations are not currently known, it is suggested that plastic formulations that do not contribute any extractable materials to blood or its fractions be developed.
Another Case of Cryptorchidism.
Authors: H. A. Carrington
Journal: JAMA (1902)

Bristol, Conn., Aug. 14, 1902. <h3>To the Editor:</h3> —A day or two before I received the August 2 number ofThe Journalcontaining Dr. Anthony's case of cryptorchidism, I was called on to make an examination of a person whose wife was about to sue him for divorce on the ground of incompetency. The patient was M. S., 32 years of age, married 9 years, 5 feet 10 inches tall, beardless, voice thin and high pitched, appearing more like a boy of 18 than of his asserted age. On examination, the penis was perfectly formed, though perhaps below the usual size, the scrotum on the left side was empty, the right side contained a small mass which might have been the epididymis, but no testicle, only a small amount of pubic hair. He claimed that he was able to have connection with his wife, but never had an emission. As
Evolocumab Lowers LDL in Genetic High Cholesterol Disorder
Authors: Anita Slomski
Journal: JAMA (2014)

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Improvement of left ventricular ejection fraction, heart failure symptoms and prognosis after revascularization in patients with chronic coronary artery disease and viable myocardium detected by dobutamine stress echocardiography
Authors: Jeroen J. Bax, Don Poldermans, Abdou Elhendy, Jan H. Cornel, Eric Boersma, Riccardo Rambaldi, Jos R.T.C. Roelandt, Paolo M. Fioretti
Journal: Journal of the American College of Cardiology (1999)