tbuckley/cabot-search huggingface dataset:
Through a Glass Darkly
Authors: Tumi Johnson
Journal: Annals of Internal Medicine (2010)

On Being a Doctor16 March 2010Through a Glass DarklyTumi Johnson, MDTumi Johnson, MDFrom Gouverneur Healthcare Services, New York University School of Medicine, New York, New York 11217.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-6-201003160-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The first time I heard the term “neglect” regarding an African mother was during my work in Niger, West Africa, as a member of the medical team of a well-respected relief organization. I might have been sitting in one of the weekly meetings at which we had to review the clinic and hospital admission numbers, deaths, and patterns of morbidity and mortality we were seeing. Someone mentioned that the reason a child had died was that “her mother waited too late to bring her in to the hospital.” A few nodded knowingly. A common scenario: Septicemia that began as a ... Author, Article, and Disclosure InformationAffiliations: From Gouverneur Healthcare Services, New York University School of Medicine, New York, New York 11217.Corresponding Author: Tumi Johnson, MD, 413 Pacific Street, Apartment 2A, Brooklyn, NY 11217. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 March 2010Volume 152, Issue 6Page: 400-401KeywordsChild healthChildrenHealth care providersMilkMorbidityMotivationNursesTasteTemperatureTuberculosis ePublished: 16 March 2010 Issue Published: 16 March 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Association between essential tremor and blood lead concentration.
Authors: Elan D Louis, Eva C Jurewicz, LaKeisha Applegate, Pam Factor-Litvak, Michael Parides, Leslie Andrews, Vesna Slavkovich, Joseph H Graziano, Spencer Carroll, Andrew Todd
Journal: Environmental Health Perspectives (2003)

Lead is a ubiquitous toxicant that causes tremor and cerebellar damage. Essential tremor (ET) is a highly prevalent neurologic disease associated with cerebellar involvement. Although environmental toxicants may play a role in ET etiology and their identification is a critical step in disease prevention, these toxicants have received little attention. Our objective was to test the hypothesis that ET is associated with lead exposure. Therefore, blood lead (BPb) concentrations were measured and a lifetime occupational history was assessed in ET patients and in controls. We frequency matched 100 ET patients and 143 controls on age, sex, and ethnicity. BPb concentrations were analyzed using graphite furnace atomic absorption spectrophotometry. A lifetime occupational history was reviewed by an industrial hygienist. BPb concentrations were higher in ET patients than in controls (mean +/- SD, 3.3 +/- 2.4 and 2.6 +/- 1.6 microg/dL, respectively; median, 2.7 and 2.3 microg/dL; p = 0.038). In a logistic regression model, BPb concentration was associated with diagnosis [control vs. ET patient, odds ratio (OR) per unit increase = 1.21; 95% confidence interval (CI), 1.05-1.39; p = 0.007]. BPb concentration was associated with diagnosis (OR per unit increase = 1.19; 95% CI, 1.03-1.37; p = 0.02) after adjusting for potential confounders. Prevalence of lifetime occupational lead exposure was similar in ET patients and controls. We report an association between BPb concentration and ET. Determining whether this association is due to increased exposure to lead or a difference in lead kinetics in ET patients requires further investigation.
Book Review Practical Color Atlas of Sectional Anatomy: Chest, abdomen, and pelvis By Edward A. Lyons. 308 pp., illustrated. New York, Raven Press, 1990. $56. A Colour Atlas of the Skull By B.K.B. Berkovitz and BJ. Moxham. 112 pp., illustrated. London, Wolfe, 1989.
Authors: A.A. Travill
Journal: New England Journal of Medicine (1990)
A Man With a Fine Talent For Idleness
Authors: George W. Corner
Journal: JAMA (1967)

Thirty years ago as a college sophomore intending to study medicine, I enrolled in a course on the English drama. For the inevitable term paper, I found "Medicine in the Modern Drama" a fascinating and rewarding subject. I explored the works of such then well-known playwrights as Ibsen, Shaw, Guitry, Romains, Schnitzler, Kingsley, and Howard. Since there was enough material for a book, I could prune and refine my paper rather than struggle to attain adequate length. That essay constituted my first publication.<sup>1</sup> I still regard that first publication with affection. The judgements still seem sound, and there is little that I would change as the result of greater maturity. However, now I can see more clearly that the plays I discussed fall into five distinct categories. Plays for the stage, movies, and television utilize medicine as part of social criticism, or satire, or history, or medical tract, or
Effects of Allergic Phenotype on Respiratory Symptoms and Exacerbations in Patients with Chronic Obstructive Pulmonary Disease
Authors: Daniel B. Jamieson, Elizabeth C. Matsui, Andrew Belli, Meredith C. McCormack, Eric Peng, Simon Pierre-Louis, Jean Curtin-Brosnan, Patrick N. Breysse, Gregory B. Diette, Nadia N. Hansel
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Rationale: Chronic obstructive pulmonary disease (COPD) guidelines make no recommendations for allergy diagnosis or treatment.Objectives: To determine whether an allergic phenotype contributes to respiratory symptoms and exacerbations in patients with COPD.Methods: Two separate cohorts were analyzed: National Health and Nutrition Survey III (NHANES III) and the COPD and domestic endotoxin (CODE) cohort. Subjects from NHANES III with COPD (n = 1,381) defined as age > 40 years, history of smoking, FEV1/FVC < 0.70, and no diagnosis of asthma were identified. The presence of an allergic phenotype (n = 296) was defined as self-reported doctor diagnosed hay fever or allergic upper respiratory symptoms. In CODE, former smokers with COPD (n = 77) were evaluated for allergic sensitization defined as a detectable specific IgE to perennial allergens. Bivariate and multivariate models were used to determine whether an allergic phenotype was associated with respiratory symptoms and exacerbations.Measurements and Main Results: In NHANES III, multivariate analysis revealed that individuals with allergic phenotype were more likely to wheeze (odds ratio [OR], 2.1; P < 0.01), to have chronic cough (OR, 1.9; P = 0.01) and chronic phlegm (OR, 1.5; P < 0.05), and to have increased risk of COPD exacerbation requiring an acute doctor visit (OR, 1.7; P = 0.04). In the CODE cohort, multivariate analysis revealed that sensitized subjects reported more wheeze (OR, 5.91; P < 0.01), more nighttime awakening due to cough (OR, 4.20; P = 0.03), increased risk of COPD exacerbations requiring treatment with antibiotics (OR, 3.79; P = 0.02), and acute health visits (OR, 11.05; P < 0.01). An increasing number of sensitizations was associated with a higher risk for adverse health outcomes.Conclusions: Among individuals with COPD, evidence of an allergic phenotype is associated with increased respiratory symptoms and risk of COPD exacerbations.
The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response.
Authors: J B Hay, B B Hobbs
Journal: The Journal of Experimental Medicine (1977)

The blood flow to individual lymph nodes of sheep and rabbits has been determined with 85Sr-labeled microspheres. A popliteal node of the sheep received 0.014% of the cardiac output and a comparable node in the rabbit 0.011%. A sheep lymph node weighing 1 g received an average of 24 ml/h of blood. It was calculated that there was a highly selective removal of lymphocytes by the node and that an equivalent to one in every four lymphocytes that entered a normal lymph node migrated out of the blood, through the substance of the node, and into the efferent lymph. During the immune response to either allogeneic lymphocytes or tuberculin, the blood flow to sheep lymph nodes, even without considering the increase in node weight, increased an average of fourfold. During the primary immune response in the rabbit to keyhole limpet hemocyanin, the blood flow increased threefold. The increase in blood flow preceded the antigen-induced increase in lymphocyte traffic recorded in the efferent lymph. The early phase of increased blood flow was considered to be due to hyperemia, whereas the latter phase had a significant angiogenesis component. It was calculated that an equivalent to 60% of the entire mobilizable pool of lymphocytes could pass through an average lymph node in the blood during an immune response lasting 5 days.
Hypercalcemia, Hypophosphatemia, and Renal Transplantation.
Authors: Gabriel H. Schwartz
Journal: Annals of Internal Medicine (1969)

s1 May 1969Hypercalcemia, Hypophosphatemia, and Renal Transplantation.Gabriel H. Schwartz, M.D., Robert R. Riggio, M.D., Paul Saville, M.D., John Whitsell, M.D., Kurt H. Stenzel, M.D., Albert L. Rubin, M.D., F.A.C.P.Gabriel H. Schwartz, M.D.Search for more papers by this author, Robert R. Riggio, M.D.Search for more papers by this author, Paul Saville, M.D.Search for more papers by this author, John Whitsell, M.D.Search for more papers by this author, Kurt H. Stenzel, M.D.Search for more papers by this author, Albert L. Rubin, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1096_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypophosphatemia and several types of hypercalcemia after renal transplantation are described. Serum and urine calcium, phosphorus, creatinine, and serum parathormone (PTH) (measured by Dr. Yalow) were followed on 25 transplanted patients. Hypophosphatemia occurred in nearly all patients and correlated with the administration of oral hydroxide antacids. Clinical effects of phosphorus depletion included weakness, intention tremor, bone pain, pseudofractures, and hypercalcemia. Treatment with oral phosphate reversed the abnormalities. Aluminum phosphate gel did not induce hypophosphatemia. Hypercalcemia of 12 to 15 mg/100 ml necessitated subtotal parathyroidectomy in five patients, two of whom had oliguria and one, polyuria due to hypercalcemia. Failure to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Gabriel H. Schwartz, M.D.; Robert R. Riggio, M.D.; Paul Saville, M.D.; John Whitsell, M.D.; Kurt H. Stenzel, M.D.; Albert L. Rubin, M.D., F.A.C.P.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1096-1096KeywordsBoneCalciumCreatinineHypercalcemiaParathyroid hormoneParathyroidectomyPhosphatesPhosphorusRenal transplantationUrine ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Pseudophysiologic Emphysema Resulting from Severe Small-Airways Disease
Authors: ARTHUR F. GELB, NOE ZAMEL, JAMES C. HOGG, NESTER L. MÜLLER, MARK J. SCHEIN
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Loss of lung elastic recoil causing hyperinflation with increased TLC and decreased diffusing capacity and expiratory airflow are physiologic hallmarks of emphysema. We studied lung mechanics in 10 patients (seven men and three women) aged 69 ± 9 yr (mean ± SD) who had fixed, severe expiratory airflow limitation with a mean FEV1 = 0.73 ± 0.1 L (mean ± SD) (32 ± 7% predicted) and lung computed tomographic picture grade score ⩽ 20, indicating no or trivial emphysema. Three patients died, in whom whole-lung emphysema scores were 15 each and small airways were abnormal. Marked hyperinflation was present in all 10 patients studied, with TLC 7.3 ± 1.1 L (140 ± 12% predicted); FRC 5.6 ± 0.8 L (177 ± 30% predicted); and RV 5.2 ± 0.8 L (242 ± 28% predicted). Diffusing capacity of carbon monoxide (Dl CO was reduced, at 12 ± 6 ml/min/mm Hg (61 ± 29% predicted). The pressure–volume curves of the lung were markedly abnormal. Pst(L) at TLC was 11.6 ± 1.4 cm H2O. Transdiaphragmatic pressure (Pdi) in five patients was 66 ± 13 cm H2O. These results indicate that severe small-airways disease with no or trivial emphysema may cause a spurious reduction in diffusing capacity as well as severe loss of lung elastic recoil resulting in marked hyperinflation, increased TLC, and decreased Pdi and expiratory airflow.
A piece of my mind. HOPE
Authors: W. M. Buchholz
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
545 DECLINE OF BONE MINERAL DENSITY DURING LONG-TERM NUCLEOS(T)IDE ANALOG THERAPY: A LONGITUDINAL COHORT STUDY OF 135 PATIENTS WITH CHRONIC HEPATITIS B
Authors: M. Viganò, P. Lampertico, R. Soffredini, F. Invernizzi, I. Chiodini, F. Facchetti, P. Beck Peccoz, M. Colombo
Journal: Journal of Hepatology (2012)
Extensive pityriasis alba: A histological histochemical and ultrastructural study
Authors: S.T. ZAYNOUN, B.G. AFTIMOS, K.K. TENEKJIAN, N. BAHUTH, A.K. KURBAN
Journal: British Journal of Dermatology (1983)

Nine patients with extensive pityriasis alba were studied using histopathological and histochemical techniques and electron microscopy. There was a reduction in the density of functional mclanocytes in the affected areas without any change in their cytoplasmic activity. The melanosomes tended to be fewer and smaller, but their distribution pattern in the keratinocytes was normal. Melanosomal transfer to keratinocytes was generally not disturbed. The histology was non-specific. Hyperkeratosis and parakeratosis were not consistently present, and it seems unlikely that they played a significant role in the pathogenesis of the hypomelanosis. A variable degree of intercellular oedema and intracytoplasmic lipid droplets were present. The hypopigmentation may thus be due primarily to the reduced numbers of active melanocytes and a decrease in number and size of melanosomes in the affected skin.
Scientists Ponder When, Why of Emerging Viruses
Authors: Charles Marwick
Journal: JAMA (1989)

WHILE SCIENTIFIC TOOLS are available to identify newly emerging or reemerging pathogens, better systems are needed to track them, say scientists who are concerned about the present inability to pinpoint when and where disease outbreaks may occur and how severe they may be. Meeting in Washington, DC, under sponsorship of the National Institutes of Health (Bethesda, Md) and Rockefeller University (New York City), they discussed bacteria and fungi, but concentrated primarily on viruses and the viral capacity to mutate. Even if the mutations do not always result in a new disease, they note, that potential is always present. <h3>Small World</h3> Furthermore, these scientists say, with modern air travel, unusual diseases can spread from one corner of the earth to another in a few hours, before physicians are aware of what is happening. Also affecting the likelihood of epidemics of new viruses, or the appearance of old viruses in new settings,
CEREBELLAR ABSCESS: OPERATION AND RECOVERY
Authors: Henry M. Goodyear
Journal: JAMA (1926)

A man, aged 26, whom I saw, May 10, 1925, gave the following history relative to his ear and brain complication: Eight weeks prior to this time he complained of an acute sore throat followed by severe pain in the left ear. Twenty-four hours later the drum ruptured spontaneously, and a continuous pus discharge followed, without mastoid tenderness at any time. The patient continued about his work as usual. However, there occurred, six weeks after the onset and two weeks before I saw him, a sudden significant attack of severe pain over the left side of the head, accompanied by nausea and vomiting. After thirty-six hours, these symptoms subsided and the patient felt well, played golf and did his work as usual, until four days before I saw him, when he again developed a severe pain over the left occipital region, accompanied by marked nausea, vomiting and dizziness. When I
Damaged Mitochondria May Link Alcohol and Muscle Weakness
Authors: Bridget M. Kuehn
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improving Outcomes for Patients With Diffuse Large B-Cell Lymphoma
Authors: C. R. Flowers, R. Sinha, J. M. Vose
Journal: CA A Cancer Journal for Clinicians (2010)

Diffuse large B-cell lymphoma (DLBCL) is the most commonly occurring form of non-Hodgkin lymphoma in the western world. Until the mid 1990s the incidence of DLBCL increased in both sexes, across racial categories, and across all age groups except the very young, the etiology of most cases remains unknown. DLBCL is associated with an aggressive natural history, but it can be cured with combination chemotherapy regimens like cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), which has been the mainstay of therapy for several decades. Remarkable progress has been made in understanding the biological heterogeneity of DLBCL and in improving survival for DLBCL patients with novel combinations of chemotherapy and immunotherapy. Gene expression profiling (GEP) has uncovered DLBCL subtypes that have distinct clinical behaviors and prognoses, and the addition of the monoclonal antibody, rituximab, to CHOP has markedly improved outcomes. Future approaches to DLBCL management will use molecular signatures identified through GEP to provide prognostic information and to isolate therapeutic targets that are being evaluated for DLBCL patients who relapse or those with high risk disease.
Effect of Nortriptyline on Symptoms of Idiopathic Gastroparesis
Authors: Henry P. Parkman, Mark L. Van Natta, Thomas L. Abell, Richard W. McCallum, Irene Sarosiek, Linda Nguyen, William J. Snape, Kenneth L. Koch, William L. Hasler, Gianrico Farrugia, Linda Lee, Aynur Unalp-Arida, James Tonascia, Frank Hamilton, Pankaj J. Pasricha
Journal: JAMA (2013)

Gastroparesis remains a challenging syndrome to manage, with few effective treatments and a lack of rigorously controlled trials. Tricyclic antidepressants are often used to treat refractory symptoms of nausea, vomiting, and abdominal pain. Evidence from well-designed studies for this use is lacking.To determine whether treatment with nortriptyline results in symptomatic improvement in patients with idiopathic gastroparesis.The NORIG (Nortriptyline for Idiopathic Gastroparesis) trial, a 15-week multicenter, parallel-group, placebo-controlled, double-masked, randomized clinical trial from the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium (GpCRC), comparing nortriptyline with placebo for symptomatic relief in idiopathic gastroparesis. One hundred thirty patients with idiopathic gastroparesis were enrolled between March 2009 and June 2012 at 7 US academic medical centers. Patient follow-up was completed in October 2012. Inclusion criteria included delayed gastric emptying and moderate to severe symptom scores using the Gastroparesis Cardinal Symptom Index (GCSI). INTERVENTIONS Nortriptyline vs placebo. Study drug dose was increased at 3-week intervals (10, 25, 50, 75 mg) up to 75 mg at 12 weeks.The primary outcome measure of symptomatic improvement was a decrease from the patient's baseline GCSI score of at least 50% on 2 consecutive 3-week GCSI assessments during 15 weeks of treatment.The primary symptomatic improvement outcome did not differ between 65 patients randomized to nortriptyline vs 65 patients randomized to placebo: 15 (23% [95% CI, 14%-35%]) in the nortriptyline group vs 14 (21% [95% CI, 12%-34%]) in the placebo group (P = .86). Treatment was stopped more often in the nortriptyline group (19 [29% {95% CI, 19%-42%}]) than in the placebo group (6 [9%] {95% CI, 3%-19%}]) (P = .007), but numbers of adverse events were not different (27 [95% CI, 18-39] vs 28 [95% CI, 19-40]) (P = .89).Among patients with idiopathic gastroparesis, the use of nortriptyline compared with placebo for 15 weeks did not result in improvement in overall symptoms. These findings do not support the use of nortriptyline for idiopathic gastroparesis.clinicaltrials.gov Identifier: NCT00765895.
Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro.
Authors: S Weber, J E Zuckerman, D G Bostwick, K G Bensch, B I Sikic, T A Raffin
Journal: Journal of Clinical Investigation (1985)

Human small cell lung carcinoma (SCLC) cells have been shown to contain significant levels of a bombesin-immunoreactive peptide. The 27-amino acid peptide, gastrin releasing peptide (GRP), has recently been shown to be responsible for the bombesin-like immunoreactivity found in SCLC cells. Among four lung cancer cell lines examined in vitro, GRP exhibited mitogenic activity for two SCLC subtypes, but not for a squamous carcinoma or adenocarcinoma lung cell line. The mitogenicity of the GRP molecule has been isolated to the carboxyterminal fragment, designated GRP 14-27, which is in part homologous to bombesin. The aminoterminal fragment, GRP 1-16, is no homologous to bombesin and exhibits no mitogenic activity. Thus, GRP may be an important growth regulating or autocrine factor in human SCLC.
Hyperparathyroidism Revealed by Renal Biopsy
Authors: B. Evans, D. Zutshi
Journal: BMJ (1962)

TBIunT 1739 dribbling of urine for one month, a burning sensation on the penis for one year, and stones near the tip of his penis for three years.He had phimosis for a long time.About 20 years ago he had acute retention of urine, which was treated with some local application.A stone was discharged through an ulcer on the dorsum of the penis, and cure resulted.For three years he had felt stones in