tbuckley/cabot-search huggingface dataset:
Development and validation of SIMS: An instrument for measuring quality of life of adults with sickle cell disease
Authors: Patricia Adams‐Graves, Kimberly Lamar, Cage Johnson, Pat Corley
Journal: American Journal of Hematology (2007)

Abstract In recent years, there has been a growing interest in the assessment of quality of life (QOL) issues, particularly in chronic debilitating conditions. Several instruments have been developed, tested, and validated in the general population and in other chronic diseases; however, few studies have examined QOL issues in adults with sickle cell disease (SCD). We developed Sickle Cell Impact Measurement Scale (SIMS), an instrument for measuring the QOL of adults with SCD. The 142‐item multi‐dimensional SIMS questionnaire was developed using 4 validated instruments and additional questions based upon recommendations of patient focus groups. The SIMS was self‐administered to 106 SCD and 45 rheumatoid arthritis (RA) patients over 4 sites. SIMS was evaluated on measures of both internal consistency and construct validity. Item reduction was performed based on results of factor analysis. The SIMS achieved good internal consistency, with a Cronbach's alpha coefficient reported of 0.86, and distinguished between patients with SCD and RA. Overall, QOL did not differ significantly among SCD and RA patients. However, SCD patients scored higher in both physical and social domains, which was expected and reflected the differences in the pathophysiology of each disease. The SIMS is a reliable, valid, and responsive questionnaire, which functions well as a discriminative instrument for the measure of health‐related QOL (HRQOL) of adults with SCD. The SIMS is currently being administered to adults with SCD across several centers for further validation to become a disease‐specific, global QOL instrument. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Abstract 5480: NSCLC cells with LKB1 mutation are vulnerable to energetic and oxidative stresses induced by 8-Chloroadenosine
Authors: Chao Yang, Maria Angelica Cortez, Uma Giri, Jayanthi Gudikote, William G. Wierda, Varsha Gandhi, Lauren Averett Byers, John V. Heymach
Journal: Cancer Research (2014)

Abstract Background: It has been demonstrated that loss of LKB1 is associated with a higher likelihood of tumor recurrence after surgery and shorter overall survival in early stage NSCLC. We sought to determine whether NSCLC tumor cells with loss of LKB1 are preferentially sensitive or resistant to various therapeutic agents. We tested 23 NSCLC cell lines, and observed that LKB1 mutant NSCLC cells are highly resistant to standard chemotherapy as well as EGFR inhibitors. In contrast, LKB1 mutant NSCLC cells are highly sensitive to 8-Chloroadenosine (8-Cl-Ado). 8-Cl-Ado is an RNA-directed nucleoside analogue, which depletes cellular ATP and triggers apoptosis in sensitive cells. LKB1 is known to play a key role in balancing cellular energy consumption and production. Therefore, we hypothesize that LKB1 mutant NSCLC cells are vulnerable to 8-Cl-Ado induced energetic stress. Method: Cellular ATP level was determined by LC-MS and luminescent based methods. Cell proliferation was measured by Celltiter-Glo assay. IC50 values were calculated by Calcusyn. Oxidative stress was measured by CellRox assay. Result: NSCLC cell lines with LKB1 mutation were significantly more sensitive to 8-Cl-Ado than wild type cell lines (p=0.024). We transfected H460 and A549 cells (both harboring mutant LKB1) with wild-type LKB1. Re-expression of LKB1 rendered cells resistant to 8-Cl-Ado (P&amp;lt;0.05). Knockdown LKB1 resulted in increased sensitivity to 8-Cl-Ado in Calu6 cells (p&amp;lt;0.05). Moreover, 8-Cl-Ado treatment caused a significant decrease in cellular ATP levels in LKB1 mutant cells. However, in A549 and H460 cells overexpressing wild-type LKB1, ATP levels were not decreased. Similarly, in H661 cells (wild-type LKB1) 8-Cl-Ado treatment did not affect ATP levels, whereas when LKB1 was knocked down by shRNA 8-Cl-Ado treatment reduced intracellular ATP levels. Furthermore, 8-Cl-Ado increased ROS levels in A549 cells but not in A549 cells overexpressing wild-type LKB1. Conclusion: Our result indicates that LKB1 mutant NSCLC cells are vulnerable to energetic and oxidative stresses induced by 8-Cl-Ado. LKB1 played a protecting role in cells under 8-Cl-Ado treatment. Citation Format: Chao Yang, Maria Angelica Cortez, Uma Giri, Jayanthi Gudikote, William G. Wierda, Varsha Gandhi, Lauren Averett Byers, John V. Heymach. NSCLC cells with LKB1 mutation are vulnerable to energetic and oxidative stresses induced by 8-Chloroadenosine. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5480. doi:10.1158/1538-7445.AM2014-5480
NICE to sort clinical "wheat from chaff"
Authors: J. Warden
Journal: BMJ (1999)

Six weeks before the National Institute of Clinical Excellence (NICE) goes live as thearbiter of NHS treatment in England and Wales, the chairman, Professor Sir Michael Rawlins, said the most important thing on his agenda is to gain the early confidence of the health professions, as well as the public and parliament.

Sir Michael appeared before the Commons health committee as the government issued a discussion …
Abstract 4829: Plasma coenzyme Q10 levels and postmenopausal breast cancer risk: The Multiethnic Cohort Study
Authors: Weiwen Chai, Christian P. Caberto, Yurii B. Shvetsov, Lynne R. Wilkens, Adrian A. Franke, Robert V. Cooney, Loic Le Marchand, Brian E. Henderson, Laurence N. Kolonel, Marc T. Goodman
Journal: Cancer Research (2010)

Abstract Background: Coenzyme Q10 (CoQ10) is a component of the mitochondrial electron transport chain and is considered an important cellular antioxidant. Lower circulating CoQ10 levels are reported in patients with breast cancer, but epidemiologic evidence from large prospective studies is lacking. We examined the association of plasma CoQ10 levels with postmenopausal breast cancer risk in prospectively collected blood samples. Methods: Plasma levels of total CoQ10 were measured by HPLC with UV detection after precolumn coulometric oxidation among 160 incident postmenopausal breast cancer cases and 289 controls in the Multiethnic Cohort Study. Cases and controls were individually-matched on age, sex, ethnicity, study location (Hawaii or California), hormone replacement therapy use, date/time of collection and hours of fasting. Conditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs). Results: Plasma CoQ10 levels were positively associated with breast cancer risk among postmenopausal women in the current study. The OR for the highest versus the lowest tertile was 1.6 (95% CI: 1.0 - 2.6; P = 0.05). The strongest association was observed for postmenopausal women under age 60 (OR for the highest versus the lowest tertile: 3.9; 95% CI: 1.1 - 14.0). Results were similar after adjusting for breast cancer risk factors. Conclusions: Higher CoQ10 levels in postmenopausal women are associated with increased breast cancer risk in this multiethnic population. Future studies are needed to define the origin of circulating CoQ10, its physiological meaning, and potential role in cancer etiology and progression. This work was supported by NIH Grants CA132149, CA33619. One of the authors (WC) was supported by NIH Training Grant CA90956. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4829.
CHEESE TID-BIT URTICARIA
Authors: M. N. Frank
Journal: JAMA (1925)

During the last two months I have come across three cases of urticaria due without doubt to cheese tid-bit (a National Biscuit Company product). <h3>ETIOLOGY</h3> The etiologic factor, though still unknown, is some toxic substance present in the food before preparation, cooking, formed during the process of the preparation (as is possible in this food known as cheese tid-bit) or possibly formed in the intestinal tract by the secretion acting on the food ingested. In these cases, the evidence so far available points to the cheese as either the harmful factor or its precursor. <h3>SYMPTOMS</h3> In all these cases, without varying an iota, the symptoms were alike. The onset was within eighteen hours after ingestion of the cheese tid-bit. Headache was the first symptom, followed by a slight nausea and then a gradual itching of the skin of the face. Within from five to ten minutes, the eyes were almost
Vitamin B12 in Nutritional Macrocytic Anaemia
Authors: C. R. D. Gupta, J. B. Chatterjea, P. Basu
Journal: BMJ (1953)

The serum vitamin B12 concentrations of patients with pernicious anaemia in relapse rose from low pretreatment levels to within the normal range after single intramuscular injections of 20 to 1,000 ,tg. of vitamin B12.Concentrations were within the normal range for from 6 to more than 18 days after injections of 20 ug.; from 2 to 22 days after 40 ,tg.; from 11 to at least 35 days after 80 jug.; from 11 to at least 48 days after 160 jug.; from 39 to 98 days after-320 ,tg.; and from 34 to at least 58 days after 1,000 ,tg.
Prognostic value of Ia+ T lymphocytes in bronchoalveolar lavage fluid in pulmonary sarcoidosis.
Authors: K Suzuki, N Tamura, A Iwase, T Dambara, S Kira
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

We investigated the value of the la+ T-lymphocyte (CD3+ HLA-DR+) ratio in bronchoalveolar lavage fluid (BALF) for predicting the outcome of pulmonary sarcoidosis. Analysis of the BALF la+ T% in 166 patients with pulmonary sarcoidosis by dual-color flow cytometry revealed a wide range of values, of from 0.5 to 85.3%. Although the majority of patients had less than 40% la+ T cells in their BALF, a minor peak was observed at 50 to 60%. The BALF la+ T% value was not influenced by smoking, sex, or age, thus differing from other BALF activation markers. Fifty patients could be followed up precisely for 3 yr after their initial bronchoalveolar lavage (BAL) to evaluate outcome with respect to chest X-ray findings, clinical symptoms, serum angiotensin converting enzyme (ACE) activity, and extrapulmonary involvement. The 50 patients were divided into two groups, with a BALF la+ T% < 40% (n = 34) and > or = 40% (n = 16), respectively. Serum ACE activity returned to normal within 1 yr in the < 40% group, but remained high for the entire follow-up period in the > or = 40% group. The significant difference was observed in the persistence of pulmonary involvement between the two groups except for four patients who showed Stage 0 disease (p < 0.02). Thirteen of 31 patients in the < 40% group showed normalization of chest X-ray findings after three years, whereas only one out of 15 patients in the > or = 40% group showed resolution of pulmonary involvement. Our results suggest that the BALF la+ T% may be a novel marker for predicting the long-term prognosis in pulmonary sarcoidosis.
ROENTGENIZATION IN THE TREATMENT OF CANCER.WITH AN EXHIBITION OF CASES IN WHICH THE EVIDENCES OF MALIGNANT DISEASE HAVE DISAPPEARED UNDER ROENTGEN RADIATION.
Authors: CLARENCE EDWARD SKINNER
Journal: JAMA (1906)

One of the burning questions before the medical profession to-day is "How shall we treat our cancer cases?" The first thought that responds is "With ablative surgery;" the second brings before us the disheartening proportion of hopeless recurrences that follows such management and which varies from 60 to 80 per cent. in different hospitals; the third invokes the Roentgen ray; the fourth, destruction of the affected tissues by caustic pastes; and the fifth, destructive sterilization of such tissues by massive mercuric cataphoresis. Of the last-mentioned, not enough is generally known as yet to render possible the formation of reliable conclusions, but the results obtained by the father of this method, Dr. G. B. Massey, Philadelphia, and by a few others, are such as to give ground for the belief that it is destined to play a not unimportant part in the future management of malignant disease. Caustic pastes are rationally
Relax: It's Onlie Sodeyne Death
Authors: Larry R. Kirkland
Journal: JAMA (1993)

<h3>To the Editor.</h3> —While I acknowledge that it may be too late to divert this flood, "sudden death" as part of the history of a live patient is, at the least, contradictory English. Expanding it to "sudden unexpected death," as in a recent article in<i>JAMA</i>,<sup>1</sup>is even worse. An enormous literature, medical and lay, has been recently directed at the problem of poor physician-patient communication, both real and perceived. This usage of "death" can only aggravate the problem. As an example, "Yes, Mrs Jones, your husband presented with sudden death, but we think he's going to be OK." The psychological effect of this terminology on patients and families cannot be ignored. Over time, the general public has come to approve, such terms as "cardiac arrest" and "heart stoppage," even with a bit of pride among some survivors, and it may eventually do the same with "sudden death." But
Biological functions of t cell lines with specificity for the intracellular bacterium Listeria monocytogenes in vitro and in vivo.
Authors: S H Kaufmann, H Hahn
Journal: The Journal of Experimental Medicine (1982)

Peritoneal exudate T lymphocytes from mice immunized with live Listeria monocytogenes were cloned in double-layer soft agar containing heat-killed L. monocytogenes (lower layer) and syngeneic accessory cells (upper layer). Colony-derived T cells were propagated in vitro in the presence of listerial antigen, syngeneic accessory cells, and T cell growth factor. In vitro proliferation, interleukin secretion, and bystander help for B cells of six such T cell lines and several sublines derived from them were found to be antigen dependent and restricted by the H-2IA locus of the major histocompatibility complex. In vivo, these T cell lines conferred delayed-type hypersensitivity to listerial antigen and protection to live L. monocytogenes. It is concluded that different biological functions of acquired antibacterial immunity can be mediated by a single T cell population.
Choreoathetotic Movement Disorder in Alcoholism
Authors: P. J. Mullin, P. W. Kershaw, J. M. W. Bolt
Journal: BMJ (1970)

A syndrome of choreoathetosis in association with alcoholism has been found in 12 patients. It appeared to occur more often in women, was transient, and may have been associated with alcohol withdrawal. It was not associated with gross liver disease, phenothiazine administration, or familial chorea, and no consistent abnormalities in whole blood thiamine or nicotinic acid, in serum magnesium, or in serum vitamin B<sub>12</sub> levels were present.
Antiretrovirals reach more people in poor countries but many still lack access, UNAIDS says
Authors: John Zarocostas
Journal: BMJ (2008)

Almost one million more people in poor countries with HIV/AIDS received antiretroviral drugs in 2007 than in 2006, bringing the total to almost three million. But an estimated 6.7 million in need were still unable to access life saving AIDS drugs, a United Nations report has said.

Peter Piot, executive director of UNAIDS, said that the increase in antiretroviral treatment was “a step forward to universal access to HIV prevention, treatment, care, and support.”

The number of people receiving antiretrovirals in sub-Saharan Africa at the end of 2007 is estimated to have reached 2.1 million, 30% of the people …
Pentazocine in Pregnancy
Authors: Vicente W. Kwan
Journal: JAMA (1970)

To the Editor.—  The increasing use of pentazocine (Talwin) as an analgesic has led to many reports of dependence as well as abuse of the drug. Its use in pregnancy like most drugs is not recommended although no teratogenic or embryotoxic effects have been observed in reproductive studies in animals. This patient had a relatively prolonged administration of pentazocine during pregnancy.  Report of a Case.—  The patient is a 23-year-old white female whose last menstrual period was Nov 5, 1968. The first two months of pregnancy were uneventful. The third month was characterized by frequent and severe low pelvic cramps and occasional spotting. The pains were controlled by the intramuscular administration of 45 to 60 mg of pentazocine every four to six hours. This was continued for approximately one month. During the fourth month of pregnancy the patient received lututrin (Lutrexin) in dosage ranging from 8 to 12 tablets a
Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet
Authors: Jonathan M. Spergel, Terri F. Brown-Whitehorn, Antonella Cianferoni, Michele Shuker, Mei-Lun Wang, Ritu Verma, Chris A. Liacouras
Journal: Journal of Allergy and Clinical Immunology (2012)
Hands as route of transmission for Klebsiella species.
Authors: M Casewell, I Phillips
Journal: BMJ (1977)

Seventeen per cent of the staff of an intensive care ward were found to have Klebsiella spp contaminating their hands, and these strains could be related to serotypes infecting or colonising patients in the ward on the same day. We identified some simple ward procedures that resulted in contamination of nurses' hands with 100-1000 klebsiellae per hand. Klebsiellae survived on artifically inoculated hands for up to 150 minutes. Handwashing with chlorhexidine hand cleanser reliably gave 98-100% reduction in hand counts, and the introduction of routine handwashing by staff before moving from one patient to the next was associated with a significant and sustained reduction in the number of patients colonised or infected with Klebsiella spp. Staff clothing was occasionally contaminated, but ward air and dust rarely contained klebsiellae.
Influence of degradation on inflammatory profile of polyphosphazene coated PMMA and trisacryl gelatin microspheres in a sheep uterine artery embolization model
Authors: Valentin Verret, Michel Wassef, Jean-Pierre Pelage, Saïda H. Ghegediban, Luc Jouneau, Laurence Moine, Denis Labarre, Jafar Golzarian, Isabelle Schwartz-Cornil, Alexandre Laurent
Journal: Biomaterials (2010)
Prevention of Sepsis during the Transition to Dialysis May Improve the Survival of Transplant Failure Patients
Authors: Olwyn Johnston, Nadia Zalunardo, Caren Rose, John S. Gill
Journal: Journal of the American Society of Nephrology (2007)

Dialysis patients are at risk for sepsis, and the risk may be even higher among transplant failure patients because of previous or ongoing immunosuppression. The incidence and the consequences of sepsis as defined by International Classification of Diseases, Ninth Revision, Clinical Modification hospital discharge diagnoses codes were determined among 5117 patients who initiated dialysis after transplant failure between 1995 and 2004 in the United States. The overall sepsis rate was 11.8 per 100 patient years (95% confidence interval [CI] 11.5 to 12.1). Sepsis was highest in the first 6 mo after transplant failure (35.6 per 100 patient years [95% CI 29.4 to 43.0] between 0 to 3 mo after transplant failure; 19.7 per 100 patient years [95% CI 17.2 to 22.5] between 3 to 6 mo after transplant failure). In comparison, the sepsis rate among incident dialysis patients between 3 and 6 mo after dialysis initiation was 7.8 per 100 patient years (95% CI 7.3 to 8.3), whereas the sepsis rate among transplant recipients between 3 and 6 mo after transplantation was 5.4 per 100 patient years (95% CI 4.9 to 5.9). Patients who were > or =60 yr, obese patients, patients with diabetes, and patients with a history or peripheral vascular disease or congestive heart failure were at risk for sepsis. Transplant nephrectomy was not associated with septicemia. The role of continued immunosuppression and vascular access creation was not assessed and should be addressed in future studies. In a multivariate analysis, patients who were hospitalized for sepsis had an increased risk for death (hazard ratio 2.93; 95% CI 2.64 to 3.24; P < 0.001). Strategies to prevent sepsis during the transition from transplantation to dialysis may improve the survival of patients with allograft failure.
Plasma Exchange in Multiple Myeloma
Authors: William F. Clark
Journal: Annals of Internal Medicine (2006)

Letters21 March 2006Plasma Exchange in Multiple MyelomaWilliam F. Clark, MDWilliam F. Clark, MDFrom London Health Sciences Centre, London, Ontario N6A 4G5, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-6-200603210-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:My coauthors and I concur that, on closer observation of our data, more questions are found than answers. We hope that most careful readers would experience this phenomenon when looking closely at data from other randomized, controlled trials. Dr. Leung raises the issue of an absence of renal biopsies and refers to an autopsy study published in 1990 (1), which indicated that 37% of patients with myeloma had light-chain or cast nephropathy and 11% had amyloidosis. Fewer than 20% of patients with myeloma have a clinical picture of acute renal failure and heavy proteinuria at diagnosis. As indicated ...References1. Ivanyi B. Frequency of light chain deposition nephropathy relative to renal amyloidosis and Bence Jones cast nephropathy in a necropsy study of patients with myeloma. Arch Pathol Lab Med. 1990;114:986-7. [PMID: 2117910] MedlineGoogle Scholar2. Montseny JJ, Kleinknecht D, Meyrier A, Vanhille P, Simon P, Pruna A, et al. Long-term outcome according to renal histological lesions in 118 patients with monoclonal gammopathies. Nephrol Dial Transplant. 1998;13:1438-45. [PMID: 9641173] CrossrefMedlineGoogle Scholar3. Pasquali S, Zucchelli P, Casanova S, Cagnoli L, Confalonieri R, Pozzi C, et al. Renal histological lesions and clinical syndromes in multiple myeloma. Renal Immunopathology Group. Clin Nephrol. 1987;27:222-8. [PMID: 3109793] MedlineGoogle Scholar4. Zucchelli P, Pasquali S, Cagnoli L, Ferrari G. Controlled plasma exchange trial in acute renal failure due to multiple myeloma. Kidney Int. 1988;33:1175-80. [PMID: 3043077] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From London Health Sciences Centre, London, Ontario N6A 4G5, Canada.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPlasma Exchange When Myeloma Presents as Acute Renal Failure William F. Clark , A. Keith Stewart , Gail A. Rock , Marion Sternbach , David M. Sutton , Brendan J. Barrett , A. Paul Heidenheim , Amit X. Garg , David N. Churchill , and Plasma Exchange in Multiple Myeloma Nelson Leung Metrics 21 March 2006Volume 144, Issue 6Page: 455KeywordsAcute renal failureBlood plasmaConflicts of interestCytogeneticsMultiple myelomaMyelomaPlasma cellsProteinuriaQuality of life ePublished: 21 March 2006 Issue Published: 21 March 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...