Azole Antifungal Drugs: Old and New
Authors: William E. Dismukes
Journal: Annals of Internal Medicine (1988)

Editorials1 August 1988Azole Antifungal Drugs: Old and NewWilliam E. Dismukes, MDWilliam E. Dismukes, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-3-177 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapeutic armamentarium against both systemic and superficial fungal infections consists primarily of the polyenes, amphotericin B and nystatin; flucytosine, a fluorinated pyrimidine analogue; and the older antifungal azoles, clotrimazole, miconazole, and ketoconazole. Results of recent studies give promise that new investigational antifungal oral azole drugs, including itraconazole, fluconazole, and SCH 39304, will be exciting additions to current compounds. Although none of these new azoles has been approved by the Food and Drug Administration yet, two of them, itraconazole and fluconazole, have already been extensively studied in in-vitro and in-vivo animal model systems, and to a lesser degree in humans....References1. AlsipStammDismukes SAW. Ketoconazole, miconazole, and other imidazoles. In: Sarosi GA, Davies SF, eds. Fungal Diseases of the Lung. Orlando: Grune & Stratton, Inc.; 1986:335-76. Google Scholar2. Galgiani J. Antifungal susceptibility tests. Antimicrob Agents Chemother. 1987;31:1867-70. CrossrefMedlineGoogle Scholar3. SaagDismukes MW. Azole antifungal agents: emphasis on new triazoles. Antimicrob Agents Chemother. 1988;32:1-8. CrossrefMedlineGoogle Scholar4. PerfectDurack JD. Penetration of imidazoles and triazoles into cerebrospinal fluid of rabbits. J Antimicro Chemother. 1985;16:81-6. CrossrefMedlineGoogle Scholar5. PerfectSavaniDurack JDD. 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Recent Advances in Antifungal AgentsDisseminated Histoplasmosis in a Danish Patient with AIDS 1 August 1988Volume 109, Issue 3Page: 177-179KeywordsAmphotericinAnimal modelsAntifungalsClinical microbiologyDrugsFood and Drug AdministrationInfectious diseasesMedical servicesMicrobiologyNystatin Issue Published: 1 August 1988 PDF DownloadLoading ...