tbuckley/cabot-search huggingface dataset:
Transient Global Amnesia Syndrome
Authors: Bernard M. Patten
Journal: JAMA (1971)

A patient with transient global amnesia was studied during the acute phase of the attack. The condition is a definite and easily recognized entity characterized by two phases. There is inability to encode recent memories, accompanied by retrograde amnesia of variable duration, with remarkable preservation of recall of distant events. In the recovery phase, the patient regains the ability to encode recent memories but still has amnesia for the events during the acute phase.
Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation
Authors: Nicolas Noiseux, Massimiliano Gnecchi, Marco Lopez-Ilasaca, Lunan Zhang, Scott D. Solomon, Arjun Deb, Victor J. Dzau, Richard E. Pratt
Journal: Molecular Therapy (2006)

We previously reported that intramyocardial injection of bone marrow-derived mesenchymal stem cells overexpressing Akt (MSC-Akt) efficiently repaired infarcted rat myocardium and improved cardiac function. Controversy still exists over the mechanisms by which MSC contribute to tissue repair. Herein, we tested if cellular fusion of MSC plays a determinant role in cardiac repair. We injected MSC expressing Cre recombinase, with or without Akt, into Cre reporter mice. In these mice, LacZ is expressed only after Cre-mediated excision of a loxP-flanked stop signal and is indicative of fusion. MSC engraftment within infarcted myocardium was transient but significantly enhanced by Akt. MSC fusion with cardiomyocytes was observed as early as 3 days, but was infrequent, and we found a low rate of differentiation of MSC into cardiomyocytes. MSC-Akt decreased infarct size at 3 days and restored early cardiac function. In conclusion, MSC-Akt improved early repair despite transient engraftment, low levels of cellular fusion, and differentiation. These new observations further confirm our recently reported data that early paracrine mechanisms mediated by MSC are responsible for enhancing the survival of existing myocytes and that Akt could alter the secretion of various cytokines and growth factors.
Letter: Consistent chromosome abnormalities in acute leukaemia.
Authors: J H Ford, S M Pittman, F W Gunz
Journal: BMJ (1974)

to likely ways in which heart disease could be prevented by alteration in diet.Drs. Ball and Tumner give the impression, too, that there is a fairly broad consensus in the dietary recommendations.This is just not true.Some authorities but not all recommend a reduction in cholesterol; some but not all a reduction in dietary fat; some but not all an increase in polyunsaturated fat; some but not all a reduction in saturated fat.Even within the reports there are some- times important differences in the opinions expressed by individual memlbers of the committees producing them.The truth is that very experienced and respected research workers continue sincerely to hold different and even contradictory views.Any statement that suggests otherwise, whether from those in the health profession or from the food industry, is unwarranted and misleading.-Iam, etc.,
Histologic outcomes in hepatitis C-infected patients with varying degrees of virologic response to interferon-based treatments
Authors: Paul J. Pockros, Fayez M. Hamzeh, Paul Martin, Ellen Lentz, Xiaolei Zhou, Sugantha Govindarajan, Anna S. Lok
Journal: Hepatology (2010)

Patients with chronic hepatitis C with partial virologic response or nonresponse to interferon-based therapies can experience treatment-related improvements in liver histology. This retrospective analysis assessed the histologic response to treatment in patients with varying degrees of virologic response (sustained virologic response [SVR], breakthrough, relapse, or nonresponse), time to hepatitis C virus (HCV) RNA undetectability, and duration of viral suppression. Patients (HCV genotypes 1-6) with baseline and follow-up liver biopsies from eight phase 2 to phase 4 interferon-based trials were analyzed. Blinded biopsies were evaluated by a single pathologist. Improvements or worsening of METAVIR necroinflammatory activity and fibrosis were defined as increase or decrease of ≥1 grading category from baseline to 24 weeks after end of treatment. A majority of the 1571 patients with paired biopsy data were white, male, with HCV genotype 1/4, baseline HCV RNA levels &gt;800,000 IU/mL, and baseline alanine aminotransferase levels ≤3 × upper limit of the normal range; mean baseline activity and fibrosis scores were 1.8 and 1.7, respectively. Overall, 80% of patients received peginterferon alfa-2a monotherapy or peginterferon alfa-2a/ribavirin combination therapy. Mean treatment duration was 46 weeks. There was a positive correlation between the degree of virologic response and improvements in METAVIR activity and fibrosis, and an inverse correlation with worsening activity and fibrosis (all comparisons, P &lt; 0.0001). Patients with SVR had the greatest histologic benefit. As a combined group, relapsers and patients with breakthrough had significantly greater benefits than nonresponders (activity, P = 0.0001; fibrosis, P = 0.003). Consistent with these results, a better histologic response was correlated with a shorter time to undetectable HCV RNA and a longer duration of viral suppression (all comparisons, P &lt; 0.0001). Conclusion: In patients with chronic hepatitis C who were treated with interferon-based therapies, histologic benefits may be observed even in the absence of an SVR. (Hepatology 2010;)
In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993)
Authors: Anthony H. Goldstone, Susan M. Richards, Hillard M. Lazarus, Martin S. Tallman, Georgina Buck, Adele K. Fielding, Alan K. Burnett, Raj Chopra, Peter H. Wiernik, Letizia Foroni, Elisabeth Paietta, Mark R. Litzow, David I. Marks, Jill Durrant, Andrew McMillan, Ian M. Franklin, Selina Luger, Niculae Ciobanu, Jacob M. Rowe
Journal: Blood (2007)
Increased Epicardial Fat Tissue is a Marker of Subclinic Atherosclerosis in Patients with Psoriasis
Authors: Bilge Bülbül Şen, Nesrin Atçı, Emine Nur Rifaioglu, Özlem Ekiz, İsmail Kartal, Eyup Buyukkaya, Mustafa Kurt, Mehmet Fatih Karakas, Şule Büyükkaya, Adnan Burak Akçay, Nihat Şen
Journal: Journal of the American College of Cardiology (2013)
Management of Prolonged Motor Seizure Activity in Children
Authors: Raul Calderon-Gonzalez
Journal: JAMA (1968)

Prolonged motor seizure activity was controlled with intravenously administered diazepam (5 to 10 mg) in 36 children ranging from one month to 12 years of age. Of the children, 10 had acute structural or metabolic cerebral disease or both, 12 had acute seizure disorder of undetermined origin, and the other 14 had old non-progressive cerebral disease. There were no serious complications secondary to this therapy.
Vicious Circles Associated with Diseases of the Skin
Authors: J. B. Hurry
Journal: BMJ (1911)

<h3>Abstract</h3> Anthropogenic activity can increase water turbidity, changing fish behaviour by reducing visibility. The spread of invasive species is also facilitated by human activity, further increasing the pressure on native species. In two experiments we measured the foraging efficiency, risk perception and inter-individual consistency of risk-taking (personality variation in boldness) of an invasive species, the Nile tilapia (<i>Oreochromis niloticus</i>), and a threatened tilapia, the Manyara tilapia (<i>Oreochromis amphimelas</i>), in clear and turbid water. In experiment one, <i>O. niloticus</i> was faster to initiate feeding, encountered more food items, and consumed more than <i>O. amphimelas</i>. The latency to start foraging by <i>O. niloticus</i> decreased in turbid water. Turbidity did not affect the latency to start foraging in <i>O. amphimelas</i> but the number of food items they encountered was highest at the intermediate turbidity. There was however no significant effect of turbidity in either species on the total food consumed. In contrast to this foraging context, in experiment two with a refuge and no food available, risk taking behaviour was similar in both species and they both responded with similarly reduced risk taking in turbid water. Evidence of personality variation was weak, being observed only in <i>O. amphimelas</i> when first leaving the shelter in turbid water. Overall, species differences were greater in the foraging context but turbidity was more important in the risk-taking context. <i>O. amphimelas</i> is more sensitive to turbidity during foraging, and <i>O. niloticus</i> is likely to have a competitive advantage in foraging situations, especially in degraded turbid habitats. <h3>Significance Statement</h3> Under human-induced environmental change, native species are often exposed to multiple stressors. Here we tested the responses of two cichlid fish to increasing turbidity. The Nile tilapia (<i>Oreochromis niloticus</i>), which is invasive throughout the tropics, and the Manyara tilapia (<i>Oreochromis amphimelas</i>), a threatened species, indigenous to Tanzania. We found that turbidity was beneficial to the foraging of <i>O. niloticus</i>, which in both clear and turbid water consumed and encountered more food than <i>O. amphimelas</i>. In contrast, without food present, both species displayed similar responses of increased risk perception in turbid water with little evidence of personality variation between individuals in either species. Our results suggest that invasive species tolerant of degraded habitats may outcompete less well adapted native species for food.
Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin
Authors: Wantong Song, Zhaohui Tang, Dawei Zhang, Ying Zhang, Haiyang Yu, Mingqiang Li, Shixian Lv, Hai Sun, Mingxiao Deng, Xuesi Chen
Journal: Biomaterials (2014)
(1) Leukocytoclastic vasculitis with chronic fibrosing panniculitis
Authors: R.R.M. Harman
Journal: British Journal of Dermatology (1977)

Journal Article (1) Leukocytoclastic vasculitis with chronic fibrosing panniculitis Get access R.R.M. Harman R.R.M. Harman Southmead Hospital, Bristol Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue s15, 1 December 1977, Pages 25–27, https://doi.org/10.1111/j.1365-2133.1977.tb14309.x Published: 01 December 1977
A meta-analysis assessing the efficacy of intranasal corticosteroids on improving nasal congestion, sleep quality, and daytime somnolence in perennial allergic rhinitis
Authors: M. Ripchinski, F. Gurevich, K. Hughes, S. Kakumanu, S. Teets, E. Lehman, V. Chinchilli, T.J. Craig
Journal: Journal of Allergy and Clinical Immunology (2003)
Effect of immunosuppressive treatment on gene expression in muscle from patients with polymyositis and dermatomyositis
Authors: Ingela Loell, Yi-Wen Chen, Rongye Shi, Marina Korotkova, Kanneboyina Nagaraju, Ingrid E Lundberg
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background</h3> Polymyositis (PM) and dermatomyositis (DM) muscle tissue is characterised by infiltrating T cells, macrophages and dendritic cells, as well as cytokines, chemokines and lipid mediators forming an inflammatory milieu. Patients are treated with glucocorticoids in combination with additional immunosuppressive drugs nevertheless patients rarely reach full recovery and persistent T cells as well as IL-1 and mPGES-1 expression has been seen in muscle tissue. Here, the authors aimed to investigate whether the expression of genes related to inflammation and muscle remodeling is affected by immunosuppressive treatment in patients with PM and DM. <h3>Patients/methods</h3> Muscle biopsies from six patients (two PM and four DM, two men and four women) taken before and after a median of 10 months (range 7, 5–16) of treatment were analysed with microarray. For verification, immunohistochemistry (IHC) and single section western blot was performed. For single section western blot, approximately 20 sections of 7 µm muscle tissue were lysed and analysed for protein content. <h3>Results</h3> Several pathways of interest were identified by microarray: ▶AIM2 inflammasome pathway is still active which could explain the persistent IL-1 expression. Upregulated genes; AIM2: 2.5 fold, Caspase 1: 2.3 fold and IL-18: 2.2 fold. ▶Interferon pathway seems unaffected by immunosuppressive treatment. Upregulated genes; STAT1: 4.3 fold, CXCL10/11: 5.6/5.9 fold and IRF8: 2.8 fold. ▶Changes in PGE2 signaling pathway. Upregulated gene; EP4: 2.0 fold, downregulated gene; EP3: −3.0. ▶Damage of muscle fiber structural proteins. Downregulated genes; FKBP5: −3.0 fold, FOXO1A: −2.5 fold. Also several proteins involved in ubiquitination/proteasome pathway were upregulated. The gene expression has so far been confirmed on protein level for STAT1, IRF8 and FOXO1A by IHC and for EP3 as well as EP4 protein expression by IHC and western blot. <h3>Conclusions</h3> Persistent inflammation in muscle tissue of patients with PM or DM might be explained by insufficient effect of conventional immunosuppressive treatment on different inflammatory pathways, such as AIM2 inflammasome, interferons and PGE2. During treatment, structural muscle proteins are negatively affected and this, concurrently with the continuing inflammation might contribute to the prolonged muscle impairment in PM and DM patients.
Lack of expression of aminoacylase-1 in small cell lung cancer. Evidence for inactivation of genes encoded by chromosome 3p.
Authors: Y E Miller, J D Minna, A F Gazdar
Journal: Journal of Clinical Investigation (1989)

A deletion involving chromosome 3p (14-23) characteristically occurs in small cell lung cancer (SCLC). Reduction to homozygosity, rather than complete loss, is typically observed for genes in the deleted region. Lack of expression for genes encoded by this region, implying inactivation of all alleles, has not been previously described. We have examined the expression of aminoacylase-1 (ACY-1), encoded by chromosome 3p21, using both an electrophoretic activity assay and a monoclonal antibody-based ELISA. A variety of human tissues, including lung, brain, liver, kidney, heart, adrenal medulla, and erythrocytes have previously been tested for ACY-1 activity and antigen; all but erythrocytes are positive. Thus, ACY-1 is expressed in all nucleated human cells examined to date. ACY-1 was undetectable in a significant number of SCLC cell lines (4/29) and tumors (1/8), but not in non-small cell lung cancer (NSCLC) cell lines (0/19) or tumors (0/9), nor in a variety of other human cell lines (0/15) or colon tumors (0/8). In addition, reduced (approximately 10% of normal) ACY-1 expression was common in SCLC cell lines (14/29) and tumors (3/8), but not in NSCLC cell lines (1/19) or tumors (0/9), nor in other human cell lines (0/15) or colon tumors (0/8). Thus, low or undetectable ACY-1 expression is highly specific for SCLC and occurs in both cell lines and tumor tissue. The finding of undetectable ACY-1 expression in SCLC supports the hypothesis that inactivation of all alleles of specific chromosome 3p genes occurs in a SCLC in a fashion analogous to Rb gene inactivation in retinoblastoma, and suggests that the structural gene for ACY-1 may be closely linked to a putative SCLC tumor suppressor gene.
Fellowship of Royal College of General Practitioners is still valuable
Authors: M. Pringle
Journal: BMJ (2013)

I am sorry that Spence is sartorially offended by the “expensive polyester merchandising tat” on offer to fellows of the Royal College of General Practitioners (RCGP).1 I have to say that I am extremely proud of my college tie (at least 30% viscose) and my RCGP cufflinks.

Joking aside, as president of the RCGP and chair of the …
1119-95 N-terminal-pro braintype natriuretic peptide predicts extent of coronary artery disease and myocardial ischemia in patients with stable angina pectoris
Authors: Michael W Weber, Roman Arnold, Torsten Dill, Matthias Rau, Vesselin Mitrovic, Klaus D Mueller, Christian Hamm
Journal: Journal of the American College of Cardiology (2004)
1097-94 Early versus delayed intervention in non-ST-elevation acute coronary syndromes: A natural experiment from the CRUSADE initiative
Authors: Jason W Ryan, Eric D Peterson, Anita Chen, Matthew T Roe, E Magnus Ohman, Christopher P Cannon, Peter B Berger, Jorge F Saucedo, Elizabeth R DeLong, Charles V Pollack, David J Cohen
Journal: Journal of the American College of Cardiology (2004)
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
Authors: Jinghui Zhang, Gang Wu, Claudia P. Miller, Ruth G. Tatevossian, James D. Dalton, Bo Tang, Wilda Orisme, Chandanamali Punchihewa, Matthew Parker, Ibrahim Qaddoumi, Fredrick A. Boop, Charles Lu, Cyriac Kandoth, Li Ding, Ryan Lee, Robert Huether, Xiang Chen, Erin Hedlund, Panduka Nagahawatte, Michael Rusch, Kristy Boggs, Jinjun Cheng, Jared Becksfort, Jing Ma, Guangchun Song, Yongjin Li, Lei Wei, Jianmin Wang, Sheila Shurtleff, John Easton, David Zhao, Robert S. Fulton, Lucinda L. Fulton, David J. Dooling, Bhavin Vadodaria, Heather L. Mulder, Chunlao Tang, Kerri Ochoa, Charles G. Mullighan, Amar Gajjar, Richard Kriwacki, Denise Sheer, Richard J. Gilbertson, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Suzanne J. Baker, David W. Ellison
Journal: Nature Genetics (2013)
Long-term release of fluocinolone acetonide using biodegradable fumarate-based polymers
Authors: A. Haesslein, H. Ueda, M.C. Hacker, S. Jo, D.M. Ammon, R.N. Borazjani, J.F. Kunzler, J.C. Salamone, A.G. Mikos
Journal: Journal of Controlled Release (2006)
Frequency, Type, and Monetary Value of Financial Conflicts of Interest in Cancer Clinical Research
Authors: Lindsay A. Hampson, Steven Joffe, Robert Fowler, Joel Verter, Ezekiel J. Emanuel
Journal: Journal of Clinical Oncology (2007)

Using data from American Society of Clinical Oncology (ASCO) Annual Meetings, we determined the frequency, type, and monetary value of researchers' financial interests.Financial disclosures for the 2004 (3,529 abstracts and 25,416 authors) and 2005 (3,556 abstracts and 26,181 authors) ASCO Annual Meetings were categorized into four groups: no author with a financial interest, research funding only, employment and leadership positions only, or at least one author with a personal financial interest. Interests were stratified by monetary value and other factors.In 2004 and 2005, 23% of abstracts had one or more authors with a personal financial interest. More than 75% of all personal financial interests were valued at less than $10,000. More than 90% of financial interests of more than $100,000 were employment related. Fewer than 3.5% of authors with personal financial interests had interests valued at more than $100,000. Overall, 6.3% (2004) and 2.9% (2005) of abstracts only had research funding, whereas 7.3% (2004) and 6.9% (2005) had only commercial employment. In 2005, 60% of plenary sessions compared with 23.1% in general poster sessions and 17.3% for publish-only abstracts reported financial ties. Personal financial interests were more common among US authors compared with non-US authors (9.2% v 4.2%).About one fourth of abstracts at ASCO Annual Meetings have an author with a personal financial interest. Most personal financial interests are valued at less than $10,000 per year, whereas a majority valued at more than $100,000 are related to employees of commercial entities.
Classification of Secondary Corneal Amyloidosis and Involvement of Lactoferrin
Authors: Kaoru Araki-Sasaki, Koji Hirano, Yasuhiro Osakabe, Masahiko Kuroda, Kazuko Kitagawa, Hiroshi Mishima, Hiroto Obata, Masakazu Yamada, Naoyuki Maeda, Kohji Nishida, Shigeru Kinoshita
Journal: Ophthalmology (2013)
Decreased lymphocytlc proliferation by mitogens in patients with transitional cell carcinoma of the renal pelvis subsequent to non-Hodgkin's lymphoma
Authors: Sadaya Matano, Shinobu Nakamura, Kazumi Kobayashi, Toshimitu Misaki, Tamotsu Matsuda, Tatsuho Suqimoto
Journal: American Journal of Hematology (1996)
Persistent Dyskinesias in Drug Users
Authors: Myron H. Marshall
Journal: JAMA (1972)

ABSTRACT To the Editor.— In this report we document persistent dyskinesias in adolescents who are members of the drug subculture in the United States and who take medications not by prescription and not therapeutically, but for behavioral and emotionally modifying responses.After the use of the phenothiazines became widespread, the attention of neurologists was called to the extrapyramidal side effects sometimes accompanying them. These included dyskinesia or abnormal movements.We must now distress the medical community by reporting the appearance of persistent neurologic sequelae in adolescent drug abusers, being careful to differentiate the persistent dyskinesia in the elderly from the serious long-standing neurologic sequelae, which may follow the illegal use of drugs.Report of Cases.—Case 1.—
Change in HbA1c as a Measure of Quality of Diabetes Care
Authors: A. F. Spitz
Journal: Diabetes Care (2006)

The Diabetes Quality Improvement Project established performance indicators that were adopted by The National Committee for Quality Assurance in the Diabetes Physician Recognition Program (DPRP) (1,2). The HbA1c (A1C) factors heavily in the scoring system, accounting for 15 of a possible 80 points. To achieve full credit,  9.0% and at least 40% must be <7.0%. This methodology may bias against diabetes consultants who are referred patients in worse control. Improvements in A1C may more readily reflect quality of care. The American Diabetes Association recommends an A1C of <7.0% (3) and in previous guidelines …
Short-Acting β-Blocker Administration in Patients With Septic Shock
Authors: Gen-Min Lin
Journal: JAMA (2014)

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Hemorrhage Into the Round Ligament
Authors: Edgar Borrero
Journal: JAMA (1983)

<h3>To the Editor.—</h3> <i>Report of a Case</i>.—A 43-year-old woman was admitted to the Manhasset (NY) Division of Long Island Jewish-Hillside Medical Center on April 27, 1982, complaining of left lower quadrant burning and sharp pain in the left groin. She had been in excellent health, with no prior surgery, and was not receiving any medications. She was gravida 3, para 2, with one spontaneous abortion. Her last menstrual period was on Feb 23, 1982. She was told on a previous examination that she had a left groin hernia. She believed she was eight weeks pregnant because she had not menstruated for two months. Two days before admission to the hospital, she began to pass blood and large clots from the vagina, which she interpreted as another spontaneous abortion. While straining, she developed sharp pain in the left groin and a burning sensation in the left lower quadrant that did