tbuckley/cabot-search huggingface dataset:
Successful treatment of bullous pemphigoid with pulsed intravenous cyclophosphamide
Authors: T. ITOH, H. HOSOKAWA, Y. SHIRAI, T. HORIO
Journal: British Journal of Dermatology (1996)

Summary Pulsed therapy with intravenous cyclophosphamide was successful in a patient with bullous pemphigoid whose disease had proved resistant to other treatments.
Vasopressor Material in Experimental Renal Hypertension
Authors: Simon Koletsky, Walter H. Pritchard
Journal: Circulation Research (1963)

Transfer of blood from rats with acute renal hypertension to normal recipient rats demonstrated that a vasopressor substance was present in the circulation of the hypertensive animals. This is consistent with the view that a humoral mechanism plays a role in the origin of the hypertension. In contrast to the acute stage, no vasoactive material could be demonstrated in the blood after the second week of hypertension. Either the amount of pressor substance was too small to detect or none was being produced. In the latter case, chronic renal hypertension cannot be attributed to a humoral mechanism.
Further Reflections on Psychosomatic Theory
Authors: Stuart Shipko
Journal: Psychotherapy and Psychosomatics (1982)

Clinical and laboratory observations of alexithymia suggest that a neurophysiologic hypothesis may be more useful than the traditional psychodynamic explanations for understanding psychosomatic processes. Current data support the concept of a functional disconnection between the two cerebral hemispheres. A mechanism for this disconnection, based on Kaplan and Wogan's experimental analogue of alexithymia, is presented. This mechanism implicates an inability to process painful stimuli through right hemispheric processes as a causitive factor in psychosomatic illness. Discussion of how this mechanism explains clinical observations of psychosomatic illness, and suggestions for further studies to elucidate and test this hypothetical mechanism are presented.
Upper gastrointestinal mucosal mast cells in infants with persistent distress and gastroesophageal reflux
Authors: R.G. Heine, M. Chehade, C.W. Chow, D.J.S. Cameron, G.P. Davidson, D.J. Moore, H.A. Sampson, D.J. Hill
Journal: Journal of Allergy and Clinical Immunology (2005)
Myocardial function in general and regional left ventricular ischaemia in dogs at control and high aortic blood pressure
Authors: J. LEKVEN, F. KIIL
Journal: Cardiovascular Research (1975)

End-diastolic dilation and reduced systolic shortening are the characteristic dimensional changes during myocardial ischaemia. Elevation of systolic aortic blood pressure by 5.3 kPa (40 mm Hg) normalized shortening and reduced myocardial dilatation when the tissue rendered ischaemic by coronary artery occlusion was less than 20% of the left ventricle. However, when the ischaemic lesion was more extensive, an adverse effect of raising aortic blood pressure was observed.
Duodenal histology, ulceration, and Helicobacter pylori in the presence or absence of non-steroidal anti-inflammatory drugs.
Authors: A S Taha, S Dahill, I Nakshabendi, F D Lee, R D Sturrock, R I Russell
Journal: Gut (1993)

Duodenitis and gastric metaplasia, which is often colonised by Helicobacter pylori (H pylori), are increasingly recognised for their importance in the pathogenesis of duodenal ulcers. The situation is not clear in patients receiving non-steroidal anti-inflammatory drugs (NSAIDs), who have a higher risk of peptic ulceration. The aim of this study was to identify the duodenal histological abnormalities in the presence or absence of NSAIDs, H pylori, and duodenal ulceration. Endoscopic duodenal biopsy specimens were taken from healthy looking mucosa of 172 patients (74 took NSAIDs, and 98 did not). Duodenitis was graded according to the degree of neutrophilic and plasma cell infiltration, villus height, Brunner9s gland prolapse, and gastric metaplasia. The activity of duodenitis was dependent on the neutrophilic infiltration. A global score covering all the above factors was constructed, and H pylori in both the stomach and duodenum, was also assessed. The results showed that duodenitis with varying degrees of neutrophilic infiltration and gastric metaplasia was found in 20 patients (27%) taking NSAIDs, compared with 56 patients (57%) not taking NSAIDs (chi 2 = 16.24, p &lt; 0.001). This degree of duodenitis was also found in 20 of 25 patients (80%) with duodenal ulcers, regardless of NSAID intake (chi 2 = 15.38, p &lt; 0.001). Gastric metaplasia was identified in 20 patients (27%) receiving NSAIDs and 38 (39%) not receiving NSAIDs. Duodenal H pylori was only seen in patients with gastric metaplasia 10 (50%) receiving NSAIDs, and 34 (89%) not receiving NSAIDs. H pylori positive gastritis, and the combination of active duodenitis and gastric metaplasia were independent predictors of duodenal ulceration. It is concluded that active duodenitis is less common in patients taking NSAIDs but is strongly associated with gastric metaplasia, H pylori positive gastritis, and duodenal ulceration. These findings are relevant to the pathogenesis and treatment of duodenal ulcers in patients taking NSAIDs.
Abstract 3430: Role of Tip60 in human melanoma cell migration, melanoma metastasis and patient survival
Authors: Guangdi Chen, Yabin Cheng, Zhizhong Zhang, Magdalena Martinka, Gang Li
Journal: Cancer Research (2012)

Abstract The tumor suppressor Tip60 plays a major role in transcription, DNA damage response, apoptosis and cancer development, but its role in melanoma is unknown. In this study, we investigated the role of Tip60 in melanoma pathogenesis and assessed its prognostic value. Using tissue microarrays consisting of 448 cases of melanomas (201 for the training set and 247 for the validation set) and 105 cases of nevi, we found that Tip60 expression was significantly reduced in metastatic melanoma compared to normal nevi (P = 0.045), dysplastic nevi (P = 0.047) and primary melanoma (P = 0.001). Kaplan-Meier survival curve and univariate Cox regression analyses showed that reduced Tip60 expression was associated with a poorer five-year disease-specific survival in primary melanoma (P = 0.016) and metastatic melanoma patients (P = 0.027). Multivariate Cox regression analyses indicated that Tip60 expression was an independent prognostic marker for primary (P = 0.002) and metastatic melanomas (P = 0.035). In vitro wound healing assay showed that enforced Tip60 expression inhibited melanoma cell migration suggesting that Tip60 might regulate melanoma metastasis. Finally, we showed that overexpression of Tip60 in melanoma cells resulted in significantly increased chemosensitivity. Our data indicate that Tip60 may serve as a potential biomarker for melanoma patient outcome as well as a potential therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3430. doi:1538-7445.AM2012-3430
The Esteem of Colleagues
Authors: Charles D. Aring
Journal: JAMA (1975)

THE DISSENTING statement by Walton Hamilton in the final report of The Committee on the Costs of Medical Care published in 1932<sup>1</sup>was summarized recently in these pages.<sup>2</sup>Hamilton said he believed that aside from the alleviation of suffering, the strongest impulse that moves the physician is the professional motive of winning the esteem of his fellows. Certainly, the latter is a potent motivating force at the outset of a medical career, although it may suffer attrition as life moves along. Hamilton noted that the profession has had to accommodate itself to a world that is largely commercial; through no fault of its own, it had to come to terms with and employ certain pecuniary devices and respond to business incentives. Rather than a collaborative enterprise with enough work and an adequate income for everyone, the tendency was to develop a system of individual business competition in the
ABC of complementary medicine: Complementary medicine in conventional practice
Authors: C. Zollman, A. Vickers
Journal: BMJ (1999)

The past 10 years has seen a significant increase in the amount of complementary medicine being accessed through the NHS. These services are not evenly distributed, and many different delivery mechanisms are used, some of which (such as homoeopathic hospitals) predate the inception of the NHS. Others depend on more recent NHS reorganisations, like general practice fundholding and health commission contracting, or have been set up as evaluated pilot projects.



Complementary therapies have been available in the NHS since its inception



#### Integrating complementary medicine into conventional settings

##### Successful integration is more likely with

##### Problems are likely with

List adapted from the report of the Delivery Mechanisms Working Party of the Foundation for Integrated Medicine

In general, development of these services has been demand led rather than evidence led. A few have published formal evaluations or audit reports. Some of these show benefits associated with complementary therapy—high patient satisfaction, significant improvements on validated health questionnaires compared with waiting list controls, and suggestions of reduced prescribing and referrals. However, data from other services are less clear, and many have not been formally evaluated These pilot projects have also identified various factors that influence the integration of complementary medicine practitioners within …
Policies on Donation After Cardiac Death at Children's Hospitals
Authors: Armand H. Matheny Antommaria, Karen Trotochaud, Kathy Kinlaw, Paul N. Hopkins, Joel Frader
Journal: JAMA (2009)

Although authoritative bodies have promulgated guidelines for donation after cardiac death (DCD) and the Joint Commission requires hospitals to address DCD, little is known about actual hospital policies.To characterize DCD policies in children's hospitals and evaluate variation among policies.Mixed-methods analysis of policies collected between November 2007 and January 2008 from hospitals in the United States, Puerto Rico, and Canada in 2 membership categories of the National Association of Children's Hospitals and Related Institutions.Status of DCD policy development and content of the policies based on coding categories developed in part from authoritative statements.One hundred five of 124 eligible hospitals responded, a response rate of 85%. Seventy-six institutions (72%; 95% confidence interval [CI], 64%-82%) had DCD policies, 20 (19%; 95% CI, 12%-28%) were developing policies; and 7 (7%; 95% CI, 3%-14%) neither had nor were developing policies. We received and analyzed 73 unique, approved policies. Sixty-one policies (84%; 95% CI, 73%-91%) specify criteria or tests for declaring death. Four policies require total waiting periods prior to organ recovery at variance with professional guidelines: 1 less than 2 minutes and 3 longer than 5 minutes. Sixty-four policies (88%; 95% CI, 78%-94%) preclude transplant personnel from declaring death and 37 (51%; 95% CI, 39%-63%) prohibit them from involvement in premortem management. While 65 policies (89%; 95% CI, 80%-95%) indicate the importance of palliative care, only 5 (7%; 95% CI, 2%-15%) recommend or require palliative care consultation. Of 68 policies that indicate where withdrawal of life-sustaining treatment can or should take place, 37 policies (54%; 95% CI, 42%-67%) require it to occur in the operating room and 3 policies (4%; 95% CI, 1%-12%) require it to occur in the intensive care unit.Most children's hospitals have developed or are developing DCD policies. There is, however, considerable variation among policies.
ESWL Now Possible for Patients With Pacemakers
Authors: Marsha F. Goldsmith
Journal: JAMA (1987)

NEWS FOR PERSONS with kidney stones who wear pacemakers—heretofore considered a contraindication for undergoing extracorporeal shock wave lithotripsy (ESWL)—came in preliminary reports at two recent meetings. At the annual meeting of the American College of Cardiology in New Orleans, Jonathan Langberg, MD, University of California, San Francisco, reported that he and colleagues tested 22 single-chamber pacemakers using 16 different models. The group didn't test any of the dual-chamber or motion-sensitive devices. Each pacemaker was suspended in the lithotriptor's water bath, with both the pulse generator and electrode positioned 5 cm from the point of highest pressure (that is, right where the patient's kidney stones would be). The pacemakers were subjected to 50 to 75 shocks—synchronized with the pulsing—and monitored continuously. None of the 22 pacemakers was damaged by the lithotriptor, and only one malfunctioned slightly. "Based on this study [which will be published in the September issue of<i>Pace</i>], we
Radionuclide Scanning and Lung Lesions
Authors: Marvin J. Shapiro
Journal: JAMA (1980)

To the Editor.—  The typical lung tumor seen in private practice is seen most often as a peripheral coin lesion. In most instances a chest x-ray film within the past five years is available and is normal. Perhaps more often here in California than elsewhere, but certainly everywhere, some of the recently developed peripheral lesions are ultimately proved to be granulomas.  In their article relative to the efficacy of radionuclide scanning in patients with lung cancer, Kelly et al (242:2855, 1979) selected their patients from among those receiving radiation for proved carcinoma of the lung. The likelihood of metastases, apparent or occult, in this group would seem to be considerably greater than among those with peripheral lesions. Yet if one were to accept their report with all of its implications, triple scans before surgery in all cases of possible lung tumor would become mandatory to avoid medicolegal complications.  Could one
Urinary Excretion of N-Acetyl-Beta-D-Glucosaminidase in Children with Type I Diabetes Mellitus
Authors: Eileen N Ellis, Ben H Brouhard, Lavenia Lagrone, Luther B Travis
Journal: Diabetes Care (1983)

N-acetyl-beta-D-glucosaminidase (NAG), a lysosomal enzyme, has been shown to be increased in the urine of patients with various glomerulonephritides, tubulointerestitial diseases, renal allograft rejection, toxic renal injury, and diabetes mellitus. Although it has been suggested that urinary NAG may reflect blood glucose control, no studies have correlated this with other measures of metabolic control. Thirty-four children from a diabetic summer camp were found to have urinary NAG to creatinine ratios significantly above those of normal controls of similar age (5.22 +/- 1.19 versus 1.51 +/- 0.17 U). Urinary NAG was found to positively correlate with an arbitrary control index (r = 0.82; P less than 0.05) and in seven patients with hemoglobin A1c (r = 0.70; P less than 0.001). In a closely followed group of 40 clinic patients, urinary NAG to creatinine ratio was again found to be significantly increased over normal controls (7.55 +/- 0.70 versus 1.51 +/- 0.17 U; P less than 0.05). Again, urinary NAG was positively correlated with HbA1c (r = 0.62; P less than 0.001) and urinary albumin to creatinine ratio (r = 0.47; P less than 0.01). In neither group was there a correlation with UNAG:UCr and duration of disease. Thus, these data suggest that urinary NAG to creatinine ratio appears to be a reflection of blood sugar control.
THE PASSAGE OF TYPE III RABBIT VIRULENT PNEUMOCOCCI FROM THE VASCULAR SYSTEM INTO JOINTS AND CERTAIN OTHER BODY CAVITIES
Authors: Morris F. Shaffer, Granville A. Bennett
Journal: The Journal of Experimental Medicine (1939)

1. Within 24 hours following intravenous inoculation with rabbit virulent strains of pneumococcus Type III, most rabbits develop infections of one or both knees. The frequency of bilateral knee joint involvement increases as the duration of the disease is prolonged. 2. The spinal fluid, aqueous humor, and bladder urine remain sterile at a time when the knee joints contain pneumococci. Subsequently, however, they may be invaded. 3. The administration of a single dose of type specific horse immune serum, at a period when in all probability one or both knee joints contain organisms, appears to be ineffective in bringing about resolution of the infections process in these sites, even though horse serum constituents may be demonstrated serologically to be present within the joint cavities.
Timolol Ophthalmic Solution and Respiratory Arrest
Authors: C. BOTET
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 August 1986Timolol Ophthalmic Solution and Respiratory ArrestC. BOTET, M.D., J. GRAU, M.D., P. BENITO, M.D., J. COLL, M.D., J. VIVANCOS, M.D.C. BOTET, M.D.Search for more papers by this author, J. GRAU, M.D.Search for more papers by this author, P. BENITO, M.D.Search for more papers by this author, J. COLL, M.D.Search for more papers by this author, J. VIVANCOS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-306_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Leier and colleagues (1) have recently reported on the cardiovascular effects of ophthalmic timolol, a beta-adrenergic blocker commonly used to treat chronic glaucoma. We report a case of respiratory arrest that occurred after a first dose of timolol.A 62-year-old woman allergic to penicillin and aspirin had a 46-year history of extrinsic asthma with multiple exacerbations in relation to seasonal environmental conditions that were usually treated with albuterol aerosols. At age 26, she had retinal detachment of the right eye and subsequent amaurosis. A few days before the current hospitalization, the diagnosis of glaucoma was established and...References1. LEIERBAKERWEBER CNP. Cardiovascular effects of ophthalmic timolol. Ann Intern Med. 1986;104:197-9. LinkGoogle Scholar2. ZIMMERMANJEFFREYHETHERINGTON TPJ. Side effects of timolol. Surg Ophthalmol. 1983;28(suppl):243-51. CrossrefMedlineGoogle Scholar3. LAURSENBJERRUM SP. Timolol eyedrop-induced severe bronchospasm. Acta Med Scand. 1982;211:505-6. Google Scholar4. MUNROERINDONEKERSHNER WJR. Systemic side effects associated with the ophthalmic administration of timolol. Drug Intell Clin Pharmacol. 1985;19:85-9. CrossrefMedlineGoogle Scholar5. PRINCECARLINER DN. Respiratory arrest following first dose of timolol ophthalmic solution. Chest. 1983;84:640-1. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital General Nuestra Señora de la Esperanza Autonomous University of Barcelona Barcelona Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySafety Implications of Vascular Endothelial Growth Factor Blockade for Subjects Receiving Intravitreal Anti–Vascular Endothelial Growth Factor TherapiesSecond place winnerSystemic Adverse Effects of Ophthalmic β-BlockersAcute Asthma Attack Due to Ophthalmic IndomethacinGerard J. Sheehan, MB, Morley R Kutzner, MD, Wu D. Chin, MB 1 August 1986Volume 105, Issue 2Page: 306-307KeywordsAspirinAsthmaBlindnessGlaucomaHospitalizationsPenicillinRetinal detachment Issue Published: 1 August 1986 PDF DownloadLoading ...
THE RELIEF OF MENOPAUSE SYMPTOMS BY ESTROGENIC PREPARATIONS
Authors: ELMER L. SEVRINGHAUS
Journal: JAMA (1935)

Therapeutic use of ovarian preparations for relief of the symptoms accompanying the menopause has met with varying and unpredictable success until within the last few years. The production of estrogenic preparations in biologically assayed form was the occasion for substantial improvement in clinical management of these patients. In 1929 the first American report of dependable treatment of the menopause with such material was published.<sup>1</sup>Corroborative reports have appeared by Bowman and Bender<sup>2</sup>in the field of psychiatry, by Hamblen<sup>3</sup>in gynecology and by Werner and Collier<sup>4</sup>in internal medicine. Experience with several standardized ovarian preparations is now so widespread among clinicians that there can no longer be the doubt of the efficacy of treatment expressed by King<sup>5</sup>in 1928. The usefulness of the estrogenic substance has been shown to extend not only to the commoner types of climacteric symptoms but also to the not infrequent
Functional dyspepsia: bye-bye to PPIs
Authors: O Nyren
Journal: Gut (2002)

Absence of therapeutic benefit of proton pump inhibitor therapy among Chinese patients with functional dyspepsia

When specifically asked, a significant proportion of the adult population reports dyspepsia—that is, pain or discomfort in the upper abdomen. The prevalence reported in the literature varies from 25% to 30%. Although only one in four patients with dyspepsia in the UK and USA sees a doctor for their symptoms1–4 dyspepsia accounts for up to 5% of consultations in family practice.5 When appropriately investigated, less than half have an underlying structural explanation for symptoms such as peptic ulcer or reflux oesophagitis. The remainder are classified as having functional dyspepsia. The vast number of patients with functional dyspepsia, and the usually chronic or recurrent nature of this ailment, creates an enormous market for the drug industry. In spite of the obvious difficulties in delimiting the patient population, and the absence of hard end points, a fair number of—mostly industry initiated—controlled trials have been conducted. However, regardless of whether the target has been gastric acid, gastrointestinal dysmotility, or Helicobacter pylori , the treatment effects have generally been unimpressive, and similar to the usually strong effects observed with placebo alone.

Although meta-analyses6–8 seem to indicate an approximately 20–30% advantage for acid suppression therapy (H2 receptor antagonists or proton pump inhibitors (PPIs)) over placebo in functional dyspepsia, the value of these secondary publications may be limited due to possible publication bias and various imperfections in the studies included. The main concern is the admixture of patients with non-erosive gastro-oesophageal reflux disease (GORD), which is known to respond to acid suppressive treatment.9 As large studies are unlikely to remain unpublished even in the event of a negative result, it appears well advised to focus on such studies. It also …