Hair Loss and 5-Aminosalicylic Acid Enemas
Authors: P.K. KUTTY
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 November 1982Hair Loss and 5-Aminosalicylic Acid EnemasP.K. KUTTY, M.B., K.R.K. RAMAN, M.D., K. HAWKEN, M.D., J.A. BARROWMAN, M.B.P.K. KUTTY, M.B.Search for more papers by this author, K.R.K. RAMAN, M.D.Search for more papers by this author, K. HAWKEN, M.D.Search for more papers by this author, J.A. BARROWMAN, M.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-5-785_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: 5-Aminosalicylic acid is believed to be the active metabolite of sulfasalazine which is used widely in the treatment of chronic inflammatory bowel disease (1, 2). Double-blind controlled trials have shown that retention enemas containing 5-aminosalicylic acid are effective in inducing remission from active ulcerative colitis (3, 4). Unlike sulfasalazine, topical 5-aminosalicylic acid is believed to be free of side effects. We report two cases of accelerated hair loss from the scalp associated with 5-aminosalicylic acid enema therapy for ulcerative proctitis.A 24-year-old white man was found in June 1981 to have idiopathic distal ulcerative colitis. The patient's...References1. AZAD KHANPIRISTRUELOVE AJS. An experiment to determine the active therapeutic moiety of sulphasalazine. Lancet. 1977;2:892-5. CrossrefMedlineGoogle Scholar2. VAN HEESBAKKERVAN TONGEREN PJJ. Effect of sulphapyridine, 5-aminosalicylic acid, and placebo in patients with idiopathic proctitis: a study to determine the active therapeutic moiety of sulphasalazine. Gut. 1980:21:632-5. CrossrefMedlineGoogle Scholar3. WILLOUGHBYPIRISTRUELOVE CJS. The effect of topical N-acetyl-5-aminosalicylic acid in ulcerative colitis. Scand J Gastroenterol. 1980:15:715-9. CrossrefMedlineGoogle Scholar4. CAMPIERILANFRANCHI MG. Treatment of ulcerative colitis with high dose 5-aminosalicylic acid enema. Lancet. 1981;2:270-1. CrossrefMedlineGoogle Scholar5. DASEASTWOODMCMANUSSIRCUS KMJW. Metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and response to treatment in in-patients. II. The relationship between metabolites and the progress of the disease studied in out-patients. Gut. 1973;14:631-41. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Newfoundland St. John's, Newfoundland Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug ReactionsComparative Tolerability of Therapies for Ulcerative ColitisDRUG-ASSOCIATED ALOPECIAMesalamine in Ulcerative ColitisAdvances in Drug Therapy for Inflammatory Bowel DiseaseMark A. Peppercorn, MDKlinik und Therapie der medikamentösen NebenwirkungenProctocolitis unresponsive to conventional therapyOlsalazine sodium in the treatment of ulcerative colitis among patients intolerant of sulfasalazineAdverse reactions to sulphasalazine and 5-amino salicylic acid in the same patientSulfasalazine Pharmacology, Clinical Use, Toxicity, and Related New Drug DevelopmentMARK A. PEPPERCORN, M.D.DRUGS AND ALOPECIA 1 November 1982Volume 97, Issue 5Page: 785-786KeywordsInflammatory bowel diseaseMetabolitesProctitisUlcerative colitis Issue Published: 1 November 1982 PDF DownloadLoading ...