A Malignant Eccrine Poroma Responds to Isotretinoin (13-cis- Retinoic Acid)
Authors: MACK ROACH
Journal: Annals of Internal Medicine (1983)

Brief Reports1 October 1983A Malignant Eccrine Poroma Responds to Isotretinoin (13-cis- Retinoic Acid)MACK ROACH III, M.D.MACK ROACH III, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-4-486 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe malignant eccrine poroma is a rare neoplasm originating in the sweat glands. Mehregan and associates (1) reported 35 cases among 450 000 consecutive biopsy specimens received over a 20-year period. This neoplasm can be mistaken for squamous cell carcinoma with acantholysis, Paget's disease, superficial spreading melanoma, and metastatic carcinoma.The histopathologic features of this disease (2) include epidermal origin, dermal and lymphatic spread, and chronic course. In the following case, a patient with eccrine poroma responded to isotretinoin (13-cis-retinoic acid) and not to conventional surgery, radiation, and chemotherapy.A 61-year-old man of Sioux Indian descent developed a nodular lesion...References1. MEHREGANHASHIMOTORAHBARI AKH. Eccrine adenocarcinoma: a clinicopathologic study of 35 cases. Arch Dermatol. 1983;119:104-14. CrossrefMedlineGoogle Scholar2. BOTTLESSAGEBIELMCNUTTJENSENDEVENEY KRNBK. Malignant eccrine poroma: case report and review of the literature. Cancer. (In press). Google Scholar3. MORIARITYDUNNDARRAGHLAMBEBRICK MJARI. Etretinate in treatment of actinic keratosis: a double-blind crossover study. Lancet. 1982;1:364-5. CrossrefMedlineGoogle Scholar4. MEYSKENSGILMARTINALBERTS FED. Activity of isotretinoin against squamous cell cancers and preneoplastic lesions. Cancer Treat Rep. 1982;66:1315-9. MedlineGoogle Scholar5. LEVINEMEYSKENS NF. Topical vitamin-A-acid therapy for cutaneous metastatic melanoma. Lancet. 1980;2:224-6. CrossrefMedlineGoogle Scholar6. STRICKLANDMAHDAVI SV. The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell. 1978;15:393-403. CrossrefMedlineGoogle Scholar7. SCOTTMEYSKENSRUSSELL KFD. Retinoids increase transglutaminase activity and inhibit ornithine decarboxylase activity in Chinese hamster ovary cells and in melanoma cells stimulated to differentiate. Proc Natl Acad Sci USA. 1982;79:4093-7. CrossrefMedlineGoogle Scholar8. DENNERTCROWLEYKOUBALOTAN GCJR. Retinoic acid stimulation of the induction of mouse killer T-cells in allogeneic and syngeneic systems. JNCI. 1979;62:89-94. MedlineGoogle Scholar9. LOTANONGCHYTILL RDF. Comparison of the level of cellular retinoid-binding of proteins and susceptibility to retinoid-induced growth inhibition of various neoplastic cell lines. JNCI. 1980;64:1259-62. MedlineGoogle Scholar10. TADARODE LARCOSPORN GJM. Retinoids block phenotypic cell transformation produced by sarcoma growth factor. Nature. 1978;276:272-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MACK ROACHIII, M.D.Affiliations: Veterans Administration Medical Center San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byManagement of Metastatic Skin Cancers in Organ Transplant RecipientsEccrine porocarcinomaTreatment of advanced malignant eccrine poroma with locoregional chemotherapyMetastatic Eccrine PorocarcinomaMetastatic Eccrine Porocarcinoma: A 5.6-Year Follow-up Study of a Patient Treated With a Combined Therapeutic ProtocolMalignant eccrine poroma in an unusual location1Malignant Eccrine Poroma with Spinal and Cerebrospinal Fluid Metastases: Case ReportMalignant Eccrine Poroma with Spinal and Cerebrospinal Fluid Metastases: Case ReportMetastatic eccrine porocarcinoma: Response to docetaxel (Taxotere) chemotherapyRetinoids: unapproved uses or indicationsIsotretinoin in dermatologyIntracranial extension of an eccrine porocarcinomaMalignant Metastatic Eccrine PoromaMetastasizing eccrine porocarcinoma: report of a case and review of the literaturePorocarcinoma of the heel: A case report with unusual histologic featuresEccrine porocarcinoma of the faceEpidermotropic eccrine porocarcinomaMetastatic sweat gland carcinoma: Response to 5-fluorouracil infusionResponse of eccrine adenocarcinoma to tamoxifenRadiation therapy and chemotherapy in malignant sweat gland tumorsDermatologic therapy: December, 1982, through November, 1983Malignant Eccrine Poroma and IsotretinoinMICHAEL FRIEDLAND, M.D., ASHOK BAJRACHARYA, M.D., ZALMEN ARLIN, M.D. 1 October 1983Volume 99, Issue 4Page: 486-488KeywordsBiopsyChemotherapyLesionsMelanomaRetinoic acidSquamous cell carcinomaSurgerySweat glands ePublished: 1 December 2008 Issue Published: 1 October 1983 PDF downloadLoading ...