tbuckley/cabot-search huggingface dataset:
IMPACT OF USE OF STATINS ON LONG-TERM INCIDENCE OF MYOCARDIAL INFARCTION, PERCUTANEOUS CORONARY INTERVENTION, AND CORONARY ARTERY BYPASS GRAFT SURGERY IN AN OUTPATIENT CARDIOLOGY PRACTICE
Authors: Hoang M. Lai, Anthony D. Mercando, Wilbert S. Aronow, Phoenix Kalen, Harit V. Desai, Kaushang Gandhi, Mala Sharma, Harshad Amin, Trung M. Lai
Journal: Journal of the American College of Cardiology (2011)
Prime minister uses London Olympics to highlight challenge of global hunger
Authors: P. Moszynski
Journal: BMJ (2012)

The UK prime minister, David Cameron, is hosting a high level summit on global nutrition and food security on 12 August, the last day of the London Olympic Games, in a bid to create a lasting international legacy.

A new report by Save the Children indicates that the number of hungry children worldwide has risen for the first time in a decade.1 It warns that a “significant rise in acutely malnourished children threatens impressive progress in cutting child mortality and getting more children into school.”

The findings come amid a “backdrop of rising food and fuel prices, which is making it much harder for families to afford to …
Ipratropium bromide in children with asthma.
Authors: N P Mann, E J Hiller
Journal: Thorax (1982)

Eighteen children between 6 and 14 years of age with perennial asthma were studied over two four-week treatment periods. Ipratropium bromide, given in addition to their current treatment, was compared with placebo using a double-blind crossover technique. The period of treatment with ipratropium was associated with a significant reduction in symptoms during both day and night and significantly higher morning peak expiratory flow rates.
Re: Richard J. Sylvester, Adrian P.M. van der Meijden, Willem Oosterlinck, J. Alfred Witjes, Christian Bouffioux, Louis Denis and Donald W.W. Newling. Predicting Recurrence and Progression in Individual Patients with Stage Ta T1 Bladder Cancer Using EORTC Risk Tables: A Combined Analysis of 2596 Patients from Seven EORTC Trials. Eur Urol 2006;49:466–77
Authors: Massimo Maffezzini
Journal: European Urology (2006)
Trinucleotide repeats: triggers for genomic disorders?
Authors: Piotr Kozlowski, Krzysztof Sobczak, Wlodzimierz J Krzyzosiak
Journal: Genome Medicine (2010)

Among the various sequence repeats that shape the human genome, trinucleotide repeats have attracted special interest as a result of their involvement in a class of human genetic disorders known as triplet repeat expansion diseases. Recently, long TGG repeat tracts were shown to be implicated in a genomic disorder resulting from chromosome 14q32.2 deletion. Various different mechanisms might trigger this deletion, and looking at the problem from a structural biology perspective may help. Deeper insight into repeated sequences and their features may shed light on the mechanisms involved in this microdeletion and similar genomic rearrangements.
Case of Mammary Cancer: Removal: Relapses
Authors: F. Troup
Journal: BMJ (1862)

Feb. 6th.He had been almost free from pain.The urine was turbid; his pulse was stronger; the appetite was improved.Feb. 7th.He could bear pressure on the affected part; had no pricking sensation; he was almost free from pain.Feb. 8tb, 9th, 10th.Oxygen was used daily since the 7th.He had been free from pain.The health had been daily improving, and the appetite was excellent.Feb. 26th.Since the 10th, oxygen had only been used every other day.He was perfectly well.
TWO CASES OF GENERALIZED BLASTOMYCOSIS.
Authors: C. CHRISTENSEN
Journal: JAMA (1906)

In neither of the cases of disseminated blastomycosis here reported is the course of the disease completed. Both patients, however, have passed out of our hands and it is extremely doubtful whether either will come again under our observation. We, therefore, place the two cases on record now and principally because certain facts noted in connection with them appear to us to ado something to our knowledge of the clinical course, especially in the earlier stages of this interesting disease. It is not necessary at this time to review in detail the facts observed in connection with the previously recorded cases. That is done satisfactorily in the recent reports by Bassoe,<sup>1</sup>by Eisendrath and Ormsby,<sup>2</sup>and, so far as the closely related "coccidioidal granuloma" in California is concerned, by Ophüls.<sup>3</sup> <h3>REPORT OF CASE 1.</h3><h3>Summary.</h3> —Man, aged 28, farmer in northeastern Iowa, was taken with acute fever
Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD
Authors: S. Chappell, L. Daly, K. Morgan, T. G. Baranes, J. Roca, R. Rabinovich, A. Millar, S. C. Donnelly, V. Keatings, W. MacNee, J. Stolk, P. S. Hiemstra, M. Miniati, S. Monti, C. M. O'Connor, N. Kalsheker
Journal: European Respiratory Journal (2007)

Ligation of both TLR2 and 9 on human cells has been shown to be associated with the development of T-reg cells and/or tolerance [5, 6].We found that HSV infection conferred protection against atopy among Finnish children only.Besides the fact that atopy is infrequent in Russian Karelia, the overall exposure to microorganisms is overwhelming and the impact of saprophytes and other pathogens may well override the possible effects of HSV on the Russian side.In summary, in an area with a relatively low microbial burden such as Finnish Karelia, herpes simplex virus appears to be able to exert immunomodulatory potential, which may have implications for the occurrence of atopy.This finding confirms the result shown previously in two other Western populations [7, 8].
Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo
Authors: Weijun Jin, John S. Millar, Uli Broedl, Jane M. Glick, Daniel J. Rader
Journal: Journal of Clinical Investigation (2003)

Endothelial lipase (EL) is a recently discovered member of the lipoprotein lipase gene family that hydrolyzes HDL phospholipids ex vivo and reduces HDL cholesterol (HDL-C) levels when overexpressed in vivo in mice. To gain further insight into the physiological role of EL in the metabolism of HDL in vivo, studies were performed in which EL was inhibited in wild-type, hepatic lipase knockout (HL–/–), and human apoA-I transgenic mice by intravenous infusion of a polyclonal antibody inhibitory to murine EL. As compared with infusion of a control antibody, infusion of the inhibitory antibody resulted in a 25–60% increase in HDL-C levels in the three mouse models, with the peak HDL-C levels occurring at 48 hours after injection. Inhibition of EL also generated larger HDL particles in the HL–/– mice. The clearance of HDL phospholipid was significantly slower in human apoA-I transgenic mice injected with an antibody against murine EL (mEL) than in mice injected with a control antibody. We conclude that inhibition of EL results in increased HDL-C levels and that EL is an important enzyme in the physiological regulation of HDL metabolism.
Excess treatment reduction including anthracyclines results in higher incidence of relapse in core binding factor acute myeloid leukemia in children
Authors: D Tomizawa, A Tawa, T Watanabe, A M Saito, K Kudo, T Taga, S Iwamoto, A Shimada, K Terui, H Moritake, A Kinoshita, H Takahashi, H Nakayama, K Koh, H Kigasawa, Y Kosaka, H Miyachi, K Horibe, T Nakahata, S Adachi
Journal: Leukemia (2013)
Residential proximity to main roads and lung function in healthy young children
Authors: S. Sonnappa, C. M. Bastardo, P. Aurora, D. Whyatt, F. J. Kelly, S. D. Beevers, J. Grigg
Journal: European Respiratory Journal (2011)

To the Editors:

In preschool children, exposure to traffic-related emissions is associated with increased prevalence of respiratory symptoms [1–3] and, in school-aged children, with reduced lung function growth [4]. However, to date, the association between air pollution and preschool lung function remains unclear. In a cross-sectional study, we investigated the effects of residential proximity to main roads and air pollutants on lung function in healthy preschool children.

Spirometric forced vital capacity, forced expiratory volume in 1 s and 0.5 s, lung clearance index (LCI) by multiple breath washout, plethysmographic specific airway resistance (s R aw) and exhaled nitric oxide fraction ( F eNO) were measured in healthy preschool children as part of another study protocol [5 …
Prevalence of nonpolypoid colorectal neoplasia: An Italian multicenter observational study
Authors: M. Bianco, L. Cipolletta, G. Rotondano, F. Buffoli, G. Gizzi, F. Tessari
Journal: Endoscopy (2010)

Corrected by: Prevalence of nonpolypoid colorectal neoplasia: An Italian multicenter observational studyEndoscopy 2010; 42(07): 563-563DOI: 10.1055/s-0030-1255547 See also: Commentaire de travail de M. A. Bianco et al., pp. 279Endoscopy 2010; 42(04): 350-350DOI: 10.1055/s-0031-1291849
The Quality of Heat Rays
Authors: L. Hill
Journal: BMJ (1939)

An organic process can develop in a patient with a psycho- genic process, and this case record is a testament to that dictum.The record of Case II illustrates a very unfortunate complicating factor in myasthenia gravis-that is, the development of a psychosis with an extreme degree of psychomotor activity.The latter without a doubt con- tributed in no small measure to the fatal outcome.I am greatly indebted to Professor D. K.
Fungal Infections of the Skin
Authors: H. C. M. Walton
Journal: BMJ (1966)

A number of fungi, known as dermatophytes, are able to cause skin infections (often called ringworm or tinea) at various body sites including the scalp, face, hands, feet, groin, and trunk. They’re the most common infections of humans. These fungi belong to three main genera – Epidermophyton, Microsporum and Trichophyton. Infection is accompanied by an itchy, inflamed characteristic rash. The disease can be transmitted from person to person or via contaminated personal care items or other objects. The fungi produce enzymes that break down skin components such as keratin and collagen to small molecules that are used as nutrients. The infection can be treated using anti-fungal agents either applied to the skin or taken orally. However, treatment failure is common often because of the prolonged treatment period required.
Becker's naevus with ipsilateral yreolar hypoplasia in three males
Authors: R. Sharma, A. Mishra
Journal: British Journal of Dermatology (1997)

Journal Article Becker's naevus with ipsilateral yreolar hypoplasia in three males Get access R. Sharma, R. Sharma Bishen Skin Centre, M‐69, Marris Road, Aligarh 202001, India Search for other works by this author on: Oxford Academic Google Scholar A. Mishra A. Mishra Niranjan Pathology Laboratory, Samad Road, Aligarh 202001, India Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 3, 1 March 1997, Pages 471–472, https://doi.org/10.1111/j.1365-2133.1997.tb14976.x Published: 01 March 1997
Points: Plasma cholesterol concentration and death from coronary heart disease
Authors: R Marquis
Journal: BMJ (1986)

August, p 395) make an important point which deserves highlighting.Fracture dislocation of the cervical spine complicating near drowning is a rare event in Britain but is seen more commonly in Australia, where body surfing is a popular sport.The advice given to rescuers in Britain is that any unconscious patient found in standing depth water should be handled as though he or she had suffered fracture dislocation of the neck.It is possible on occasions to ventilate adequately without extending the neck, but if this is not the case then the rescuer has no alternative but to tilt the head back.
M-Mode and Two-dimensional Echocardiographic Abnormalities in Systemic Lupus Erythematosus
Authors: Alice V. Klinkhoff
Journal: JAMA (1985)

A prospective clinical and echocardiographic study of 47 patients with systemic lupus erythematosus (SLE) and 46 age- and sex-matched controls showed an increased prevalence of echocardiographic abnormalities in the SLE group. Pericardial abnormalities were identified in ten patients with SLE and in no controls. Excluding mitral valve prolapse, valvular abnormalities were identified in ten patients with SLE (21%) and in three controls (7%). In the patients with SLE, abnormalities included mitral valve leaflet thickening in six, aortic valve thickening in five, and mitral annular calcification in two. The presence of valvular abnormalities correlated with duration but not with severity of SLE. The finding of systolic murmurs in 17 of 47 patients with SLE did not correlate with echocardiographic evidence of valvular disease. In six patients with SLE, valvular abnormalities detected by two-dimensional echocardiography were not seen on M-mode echocardiogram.
American cardiothoracic trainees want longer hours too
Authors: J. P Jacobs, K. H Nguyen, J. H Stevens
Journal: BMJ (1995)

examine a woman who had been involved in a vehicle accident on her way to the airport.The accident was sufficiently violent to have fractured a long bone.Despite having "attended an advanced trauma and life support course" he failed to examine the patient properly-on his own admission he did not carry out a full primary survey of the patient at the outset.Nor did he insist that the patient be transferred from the plane for a proper evaluation, which would have been simple and taken only a few minutes.Admittedly, the "Heath Robinson" chest tube drainage that he performed during the flight was ingenious, but what if she had had a ruptured liver or spleen?His Sellotape and coat hanger would not have helped then.Surely the best way of managing an in flight emergency is to avoid it if at all possible.
An approach to the toxicology of combustion products of materials.
Authors: J H Petajan
Journal: Environmental Health Perspectives (1976)

Physiological and behavioral (conditioned avoidance) responses of male Long-Evans rats were determined during exposure to combustion products produced on thermal degradation of three different polymeric materials. Arterial blood samples were obtained for determination of carboxyhemoglobin (COHb) and acid/base status. Material A produced a syndrome of carbon monoxide (CO)-induced anoxia, the severity of which was a function of the mass of material degraded. Material B produced grand mal seizures despite COHb levels of less than 10%. Material C produced metabolic acidosis and a mild degree of CO-induced anoxia. Loss of avoidance responses occurred at significantly lower COHb levels for materials B and C in comparison to CO alone. Using responses to COHb as a reference, it was possible to detect the presence of other toxicants present in combustion products. Compounds found in smoke in very low concentrations may have a high degree of biological activity and be responsible for impairment of survival responses. We have labeled these compounds "limiting" toxicants. They constitute a significant hazard, which is added to that of CO and anoxia.
Laser photoablation of ventricular tachycardia: Correlation of diastolic activation times and photoablation effects on cycle length and termination-observations supporting a macroreentrant mechanism
Authors: Robert H. Svenson, Laszlo Littmann, Paul G. Cola Vita, Samuel H. Zimmern, John J. Gallagher, John M. Fedor, Jay G. Selle
Journal: Journal of the American College of Cardiology (1992)
Randomized Controlled Trial of Exercise Training in Postmenopausal Breast Cancer Survivors: Cardiopulmonary and Quality of Life Outcomes
Authors: Kerry S. Courneya, John R. Mackey, Gordon J. Bell, Lee W. Jones, Catherine J. Field, Adrian S. Fairey
Journal: Journal of Clinical Oncology (2003)

Purpose: To determine the effects of exercise training on cardiopulmonary function and quality of life (QOL) in postmenopausal breast cancer survivors who had completed surgery, radiotherapy, and/or chemotherapy with or without current hormone therapy use. Methods: Fifty-three postmenopausal breast cancer survivors were randomly assigned to an exercise (n = 25) or control (n = 28) group. The exercise group trained on cycle ergometers three times per week for 15 weeks at a power output that elicited the ventilatory equivalent for carbon dioxide. The control group did not train. The primary outcomes were changes in peak oxygen consumption and overall QOL from baseline to postintervention. Peak oxygen consumption was assessed by a graded exercise test using gas exchange analysis. Overall QOL was assessed by the Functional Assessment of Cancer Therapy–Breast scale. Results: Fifty-two participants completed the trial. The exercise group completed 98.4% of the exercise sessions. Baseline values for peak oxygen consumption (P = .254) and overall QOL (P = .286) did not differ between groups. Peak oxygen consumption increased by 0.24 L/min in the exercise group, whereas it decreased by 0.05 L/min in the control group (mean difference, 0.29 L/min; 95% confidence interval [CI], 0.18 to 0.40; P &lt; .001). Overall QOL increased by 9.1 points in the exercise group compared with 0.3 points in the control group (mean difference, 8.8 points; 95% CI, 3.6 to 14.0; P = .001). Pearson correlations indicated that change in peak oxygen consumption correlated with change in overall QOL (r = 0.45; P &lt; .01). Conclusion: Exercise training had beneficial effects on cardiopulmonary function and QOL in postmenopausal breast cancer survivors.
Clinical Capillary Microscopy
Authors: Nancy E. Warner
Journal: JAMA (1967)

This comprehensive photographic atlas of normal and diseased living human capillaries in nail fold, bulbar conjuctiva, tongue, lip, and gingiva is the first book of its kind. As such, it represents a milestone in the field and an impressive record of the authors' personal investigations of normal subjects and patients during the past 25 years. While such studies are by no means new (early observations of conjuctival vessels are attributed to Boerhaave), it is only in recent years that capillary microscopy has begun to be used as a tool in the study of human disease. Whereas more elaborate experimental techniques of illumination, recording, and amplification of images hold promise for future investigation, the authors have used relatively simple, readily available equipment. They advocate wider utilization of capillary microscopy as part of routine, complete clinical examination, and the method in their hands has proved useful, yielding findings relevant to the diagnosis
Neutrophilic dermatosis with myelodysplastic syndrome: Nuclear segmentation anomalies of neutrophils in the skin lesion and in peripheral blood
Authors: Naoko Morioka, Fujio Otsuka, Toshitatsu Nogita, Kyoko Igisu, Akio Urabe, Yasumasa Ishibashi
Journal: Journal of the American Academy of Dermatology (1990)
Wrist Circumference Is a Clinical Marker of Insulin Resistance in Overweight and Obese Children and Adolescents
Authors: Marco Capizzi, Gaetano Leto, Antonio Petrone, Simona Zampetti, Raffaele Edo Papa, Marcello Osimani, Marialuisa Spoletini, Andrea Lenzi, John Osborn, Marco Mastantuono, Andrea Vania, Raffaella Buzzetti
Journal: Circulation (2011)

Excess fat is one of the main determinants of insulin resistance, representing the metabolic basis for developing future cardiovascular disease. The aim of the current study was to find an easy-to-detect clinical marker of insulin resistance which can be used to identify young subjects at increased risk of cardiovascular disease.Four-hundred and seventy-seven overweight/obese children and adolescents (mean age 10.31±2.80 years) were consecutively enrolled. Standard deviation score body mass index, fasting biochemical parameters, and homeostasis model assessment of insulin resistance were evaluated. Statistical differences were investigated using multiple linear regression analysis. Manual measure of wrist circumference was evaluated in all children and adolescents. Fifty-one subjects, randomly selected, underwent nuclear magnetic resonance imaging of the wrist to evaluate transversal wrist area at the Lister tubercle level. A statistically significant association was found between manual measure of wrist circumference and insulin levels or homeostasis model assessment of insulin resistance (β=0.34 and 0.35, respectively; P<10(-5) for both comparisons). These associations were more significant than those between SD score body mass index and insulin levels or homeostasis model assessment of insulin resistance (β=0.12 and 0.10, respectively; P≤0.02 for both comparisons). Nuclear magnetic resonance imaging acquisition clarified that the association between wrist circumference and insulin levels or homeostasis model assessment of insulin resistance reflected the association with bone tissue-related areas (P≤0.01 for both) but not with the adipose tissue ones (P>0.05), explaining 20% and 17% of the variances of the 2 parameters.Our findings suggest a close relationship among wrist circumference, its bone component, and insulin resistance in overweight/obese children and adolescents, opening new perspectives in the prediction of cardiovascular disease.
And on the Farm...
Authors: Teri Randall
Journal: JAMA (1990)

PLOWING a field is almost as dangerous as working in a coal mine in this country, and the federal government now has allocated additional funds to further promote the safety of the nation's 3.6 million agricultural workers. According to statistics from the National Institute for Occupational Safety and Health (NIOSH), within the CDC, agriculture ranks as the fourth most hazardous industry in the United States, with a mortality rate of 21 deaths per 100 000 workers. The rate is nearly four times the national average of all occupations. Only mining (31 deaths per 100 000 workers), the transportation, communications, and utilities industries (26 deaths per 100 000 workers), and construction (25 deaths per 100 000 workers) carry higher mortality risks. The National Safety Council estimates that about 1600 farmers and agricultural workers are killed in farm accidents every year and an additional 170 000 are injured or become seriously ill—half
NAB Domain Is Essential for the Subunit Assembly of both α–α and α–β Complexes of Shaker-like Potassium Channels
Authors: Weifeng Yu, Jia Xu, Min Li
Journal: Neuron (1996)

There are at least five subfamilies of Shaker-like K+ channels. The diverse functions of K+ channels are thought to be further modulated by hydrophilic β subunits. Here we report that Kvβ1 inactivates RCK4 and Shaker B K+ channels of the Kv1 subfamily, but not Shal2 of the Kv4 subfamily. This correlates the subfamily-specific binding of Kvβ1 to the cytoplasmic N-terminal domains of Kv1 α subunits. We map the Kvβ1-binding site to a region overlapping NABKv1, a domain that specifies different Kv1 α subunits to form heterotetramers. Using chimeric α subunits, we demonstrate that NABKv1 is essential for the Kvβ1-mediated inactivation. These results suggest that Kvβ1 modulates a subset of K+ channels through the specific assembly of α–β complexes and reveal the dual function of the NAB domain in mediating the assembly of both α–α and α–β complexes.