tbuckley/cabot-search huggingface dataset:
The Continuing Evolution of Pediatric Emergency Care
Authors: Evaline A. Alessandrini, Joseph L. Wright
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Abstract 2989: Depletion of the Topoisomerase I binding proteins BTBD1 and BTBD2 alters the DNA damage response in tumor cells treated with camptothecin
Authors: Christian Kurtis, Peter D'Arpa, Mary L. Cutler
Journal: Cancer Research (2010)

Abstract The Topoisomerase I (Top1) binding proteins BTBD1 and BTBD2 belong to a family of structurally related proteins of diverse function. BTBD1 and BTBD2 are highly homologous (&amp;gt;80% identity) and are comprised of an N-terminal BTB/POZ domain, typically involved in protein-protein interactions, followed by a related BACK (BTB and C-terminal Kelch) domain. The carboxy-terminal half of these proteins have been shown to be the Top1 binding portion (Xu et al., 2002) and contain a PHR domain found in certain E3 ubiquitin ligases. Understanding the role of BTBD1 and 2 proteins, with an emphasis on the effects of their depletion by RNAi and concomitant treatment of cells with the Top1 specific camptothecin (CPT) family of chemotherapeutic agents, is the focus of this present study. Treatment of cells with CPT and related analogues results in Top1 mediated DNA damage that was assayed by detection of the phosphorylation of DNA damage response elements (DDRE), including ATM, ATR, Chk1 and H2A.X, by Western blot. We have observed a &amp;gt;5-fold activation of the basal levels of DDRE in cells in which BTBD1 and BTBD2 have been depleted by RNAi. Furthermore, the response to CPT in these cells is temporally accelerated compared to cells treated with a non-specific control siRNA and CPT. In addition, immunofluorescent studies have revealed that there is a clearing of Top1 from the nucleoli of BTBD1 and 2-depleted cells even in the absence of CPT treatment. Recently characterized members of the BTB family of proteins have been shown to be involved in the repair of DNA damage (Munoz et al., 2009). It appears that BTBD1 and 2 proteins are involved in the response to DNA damage induced by Top1 specific drugs and as such open a new area of study with potential for development of novel combination therapies. Xu L, et al., BMC Genomics. 2002. 3(1). Muñoz IM, et al., Mol Cell. 2009. 35:116-27. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2989.
Case 56-1966
Authors: Hugh H. Kopald, Richard B. Cohen
Journal: New England Journal of Medicine (1966)

Presentation of CaseA forty-nine-year-old man entered the hospital because of pain in the foot.Two months previously he had been admitted to a nursing home with the diagnoses of "chronic alcoholism, pulmonary emphysema, senile changes and stasis changes of the left leg." The personnel of the nursing home believed that he had experienced pain in the left foot and leg for several years. During the four days before admission the left foot was cold, blue and more painful.Physical examination revealed a lethargic, confused, obese man. There was mild cyanosis of the lips, and the tongue was thick. The . . .
A METHOD FOR THE DETERMINATION OF THE BLUE DYE T-1824 IN PLASMA
Authors: Robert Allan Phillips
Journal: The Journal of Experimental Medicine (1943)

A method for the estimation of the concentration of the blue dye, T-1824, in plasma has been developed. The method is based on the fact that the dye can be reduced to a colorless compound by Na2S2O4, in alkaline solution. The extinction coefficient is determined under specified conditions before and after reduction of the dye. Under the conditions employed hemoglobin does not interfere, even if partly present as HbCO or as methemoglobin; the absorption of light by the hemoglobin is the same before and after reduction of the dye. Absorption of light by suspended lipids and plasma pigments is also unaltered by the Na2S2O4. Hence variations from sample to sample in hemolysis or degree of lipemia do not affect the accuracy with which T-1824 is determined.
Bedside haemodynamic monitoring: experience in a general hospital.
Authors: J Bayliss, M Norell, A Ryan, M Thurston, G C Sutton
Journal: BMJ (1983)

Bedside right heart haemodynamic monitoring was carried out on 55 occasions over 18 months in the cardiac care unit of a district general hospital. The technique was used to assist in the management of 27 patients with acute heart failure by helping to select appropriate treatment. Although the catheters were flow guided, insertion and positioning were facilitated by fluoroscopy. The procedure was safe, with one complication arising; technical difficulties occurred in eight cases. Prediction of cardiac output and left ventricular filling pressure by clinical assessment proved to be accurate in only 55% of cases: in patients with acute heart failure there was a tendency to underestimate the cardiac output (25%) and overestimate the left ventricular filling pressure (37%), whereas in patients with chronic heart failure the filling pressure was more accurately estimated (71%). Haemodynamic measurement was often invaluable in selecting and adjusting treatment, particularly in critically ill patients.
HEXAMETHYLENAMIN POISONING IN THE RUBBER INDUSTRY
Authors: HERBERT J. CRONIN
Journal: JAMA (1924)

Hexamethylenamin poisoned sixty employees in a local rubber factory. Acute dermatitis of the exposed surfaces was the principal symptom. Removal of this chemical from all rubber stock alone prevented further cases. <h3>RUBBER CATALYZERS</h3> Rubber is a colloidal, organic compound, the exact chemical composition of which is unknown. It was discovered that when rubber was mixed with sulphur and heated, the product became stable and useful. This process is called vulcanization. It was next found that the addition of lead accelerated the action of the sulphur, and made a better end-product. Later, several organic chemicals have been used as accelerators or catalyzers, and hexamethylenamin is one of the most recent. Hexamethylenamin, C<sup>6</sup>H<sup>12</sup>N<sup>4</sup>, is formed by the action of ammonia on formaldehyd. It occurs in colorless, odorless crystals, or as a white crystalline powder, having a slightly sweetened taste. It is soluble in 1.5 parts of water
Undue Distinction of Sex
Authors: William H. Masters, Virginia E. Johnson
Journal: New England Journal of Medicine (1969)

The Mudd—Siegel contribution in this issue has refocused attention on the salient feature that medical students conceive themselves less at ease taking a sexual than a medical history. The mere fact that there is consideration of two separate histories, not only by the medical students, but conceptually by the proponents of the questionnaire, speaks volumes for the influence of our culture. Why should there ever have been the professional suggestion that there are two distinct types of material — that of medical and that of sexual moment?Obviously, Mudd and Siegel are but reflecting the current state of biologic and . . .
Effect of intranasal administration of semliki forest virus recombinant particles expressing reporter and cytokine genes on the progression of experimental autoimmune encephalomyelitis
Authors: Alan Jerusalmi, Margaret M Morris-Downes, Brian J Sheahan, Gregory J Atkins
Journal: Molecular Therapy (2003)

We have initiated studies to determine the feasibility of employing the Semliki Forest virus (SFV) expression system as a central nervous system (CNS) vector. We investigated the effects of infecting Balb/c mice intranasally (i.n.) with recombinant SFV particles expressing the enhanced green fluorescent protein (EGFP) reporter gene. EGFP expression was detected by fluorescence microscopy in the olfactory bulb as early as 1 day postinfection. No pathological changes were associated with infection. Viral RNA could be detected in the olfactory mucosa only, whereas fluorescence was detected in axons in the olfactory bulb, indicating that only the expressed protein was present. A vector expressing interleukin 10 (IL-10) was constructed and shown to induce good cytokine expression in cultured cells. IL-10 expression in the nasal passage and olfactory bulb of infected mice was enhanced following i.n. administration of such particles. Mice induced for experimental autoimmune encephalomyelitis (EAE) were treated i.n. with vectors expressing EGFP and IL-10 and with empty vector. The EGFP-expressing and empty vectors were found to exacerbate EAE, whereas that expressing IL-10 ameliorated EAE. It is concluded that the mice showed a significant biological response when treated i.n. with recombinant SFV particles and that such particles administered by the i.n. route have potential as a noninvasive vector for protein delivery to the CNS.
Goitrogenic and estrogenic activity of soy isoflavones.
Authors: Daniel R Doerge, Daniel M Sheehan
Journal: Environmental Health Perspectives (2002)

Soy is known to produce estrogenic isoflavones. Here, we briefly review the evidence for binding of isoflavones to the estrogen receptor, in vivo estrogenicity and developmental toxicity, and estrogen developmental carcinogenesis in rats. Genistein, the major soy isoflavone, also has a frank estrogenic effect in women. We then focus on evidence from animal and human studies suggesting a link between soy consumption and goiter, an activity independent of estrogenicity. Iodine deficiency greatly increases soy antithyroid effects, whereas iodine supplementation is protective. Thus, soy effects on the thyroid involve the critical relationship between iodine status and thyroid function. In rats consuming genistein-fortified diets, genistein was measured in the thyroid at levels that produced dose-dependent and significant inactivation of rat and human thyroid peroxidase (TPO) in vitro. Furthermore, rat TPO activity was dose-dependently reduced by up to 80%. Although these effects are clear and reproducible, other measures of thyroid function in vivo (serum levels of triiodothyronine, thyroxine, and thyroid-stimulating hormone; thyroid weight; and thyroid histopathology) were all normal. Additional factors appear necessary for soy to cause overt thyroid toxicity. These clearly include iodine deficiency but may also include additional soy components, other defects of hormone synthesis, or additional goitrogenic dietary factors. Although safety testing of natural products, including soy products, is not required, the possibility that widely consumed soy products may cause harm in the human population via either or both estrogenic and goitrogenic activities is of concern. Rigorous, high-quality experimental and human research into soy toxicity is the best way to address these concerns. Similar studies in wildlife populations are also appropriate.
Abstract 3655: Stem cell-associated gene Lin-28B genotype and phenotype in epithelial ovarian cancer and their associations with disease survival outcomes
Authors: Lingeng Lu, Dionyssios Katsaros, Harvey Risch, Herbert Yu
Journal: Cancer Research (2012)

Abstract Several single nucleotide polymorphisms (SNPs) in lin-28B, a gene encoding RNA binding protein that represses miRNA let-7 maturation and acts as an oncogene, were found in the genome-wide association studies (GWAS), to be associated with the risk of ovarian cancer and cancer-related risk factors such as age at menarche, body mass index (BMI) and height. However, whether these SNPs are functionally important and can serve as prognostic markers in ovarian cancer remain unknown. The purposes of this study were to investigate the genotype-phenotype relationship in lin-28B and their associations with patient survivals in epithelial ovarian cancer. To achieve these purposes, we analyzed five lin-28B SNPs using Taqman® assays and lin-28B expression using SYBR green-based qPCR in tumor samples collected from 211 patients diagnosed with primary epithelial ovarian cancer. Wilcoxon rank sum test was performed to analyze cis-regulatory eQTL; Kaplan-Meir survival curves and Cox proportional hazards regression models were used to assess the associations of lin-28B SNPs and expression with the risks of relapse and death. The results showed that three SNPs (rs314276, rs314277 and rs7759938) were associated with lin-28B mRNA levels. Using mfold, rs314276 and rs314277 were predicted to affect the secondary structures of lin-28B mRNA. SNP rs7759938 is located at the 500 bp downstream of the region with H3K4Me1 (an enhancer marker) enrichment restricted to stem cells. However, these SNPs were not significantly associated with clinical and pathological parameters including disease stage, tumor grade, histological types, residual tumor size, and debulking results. No SNPs alone were related to patient survivals. Among patients initially responding to chemotherapy, those with high lin-28B expression had higher risks of death (hazard ratio (HR)=3.27, 95% CI: 1.63-6.56), and relapse (HR=2.53, 95% CI: 1.41-4.54) than those with low one. After adjustment for patient age at surgery, disease stage, tumor grade, histological types and residual tumor size, the associations were still statistically significant. These findings suggest that 3 of the GWAS-hit SNPs in lin-28B may affect gene expression, but these SNPs are not associated with ovarian cancer survival. The results also indicate that lin-28B may affect the outcome of chemotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3655. doi:1538-7445.AM2012-3655
Multilineage Priming of Enhancer Repertoires Precedes Commitment to the B and Myeloid Cell Lineages in Hematopoietic Progenitors
Authors: Elinore M. Mercer, Yin C. Lin, Christopher Benner, Suchit Jhunjhunwala, Janusz Dutkowski, Martha Flores, Mikael Sigvardsson, Trey Ideker, Christopher K. Glass, Cornelis Murre
Journal: Immunity (2011)
National measles and rubella vaccination campaign
Authors: E B P Wiratunga, J. O'Brien
Journal: BMJ (1995)

EDITOR,—The national schools measles and rubella campaign of November 1994,1 2 3 in which most districts attained coverage of 90%, has been a success.4 This was despite adverse publicity and concern regarding possible adverse reactions to a new vaccine. All adverse reactions were reported to the Committee on Safety of Medicines through the yellow card system, with a copy to the immunisation coordinator. We analysed the information in St Helens and Knowsley district with EpiInfo version 5.00.

Altogether 48000 children were immunised during November 1994, with an uptake rate of 90%. One hundred and sixteen reports (0.24%) …
Scintigraphic Characterization of Amyloid Cardiomyopathy
Authors: CURTIS K. LI, MARK A. RABINOVITCH, JACK E. JUNI, JAMES H. THRALL, BERTRAM PITT, SUNIL K. DAS, GERALD D. ABRAMS, MARK HELVIE
Journal: Clinical Nuclear Medicine (1985)

Amyloidosis is an important entity in the differential diagnosis of cardiac failure of undetermined etiology. In this case report, the typical pattern of combined systolic and diastolic impairment in amyloid cardiomyopathy was demonstrated by analysis of the cardiac blood pool study. In addition, the patient described had mild uptake of Ga-67 citrate, as well as the characteristically intense myocardial uptake of Tc-99m pyrophosphate. Scintigraphic assessment may be particularly helpful when the diagnosis of amyloidosis is being considered in a patient with unexplained cardiac failure.
Mary Louise Grove-White (nee Wilson)
Authors: I. Grove-White
Journal: BMJ (2008)

Born in Belfast, Mary Louise Grove-White (nee Wilson) entered medical school at Trinity College, Dublin, in 1935. She left to join her husband, John, in the Malayan Medical Service in 1939. She was evacuated from Singapore in 1942 with her two children, and it was to be nearly two years before she …
Hemodynamic effects of the endothelin-1 receptor antagonist Bosenian at different stages of heart failure in conscious dogs
Authors: Rémi Choussat, Fabrice Barbe, Jinbo Su, Geneviève Maistre, Alain Carayon, Bertrand Crozatier, Luc Hittinger
Journal: Journal of the American College of Cardiology (1996)
Beyond Beijing: putting words into action.
Authors: C Blaney
Journal: Environmental Health Perspectives (1996)

The Fourth World Conference on Women acknowledged that environmental degradation 1) disproportionately affects poor women who are powerless to control it, 2) is linked to poverty, and 3) jeopardizes women's reproductive health. Thus, the Platform for Action addresses environmental inequalities among its 12 areas of critical concern, and the governments who signed the consensus agreed to take almost two dozen specific environmental actions in the areas of 1) involving women in environmental decision-making, 2) integrating gender concerns in sustainable development, and 3) assessing the impact of developmental and environmental policies on women. The NGO (nongovernmental organization) Forum held in conjunction with the Conference acted as the environmental conscience of the Conference. In their discussions of environmental matters, NGO Forum participants introduced new concepts, such as that of environmental injustice or imperialism, into the international lexicon. They sought to develop a worldwide network working for social changes through the power of information sharing. Specific commitments to provide clean water to citizens were made by several countries, Cambodia pledged to include women in sustainable development programs, and Lesotho agreed to educate women about alternative energy sources. The US created the President's Interagency Council on Women to follow through on platform pledges. The environmental efforts of this Council will focus on improving women's health. NGOs throughout the world are holding a series of meetings to exchange information about the Conference and to suggest implementation methods.
Decision making by primary care trusts prejudices patient survival
Authors: A. Gulland
Journal: BMJ (2010)

Hydroquinone, an activator of caspase-9 activity via reactive oxygen species, and farnesol, a post-translational down-regulator of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity suppress the growth of murine B16 melanoma cells. Our previous studies have shown that farnesyl-O-acetylhydroquinone has a markedly greater growth-suppressive activity than that predicted by the responses to the parent compounds. Perillyl alcohol, a modulator of small G-protein activity, and biphenyl compounds, activators of Fas-mediated death pathways, suppress B16 growth. A similar synergistic increase in the potency of each compound when ether-linked to acetylhydroquinone is reported. Perillyl-O-acetylhydroquinone, biphenylethyl-O-acetylhydroquinone and biphenylpropyl-O-acetylhydroquinone had dose-dependent impacts on the proliferation of B16 cells with 50% inhibitory concentration (IC<sub>50</sub>) values of 8.0, 4.2 and 1.4 μmol/L, respectively. The growth-suppression effected by biphenylpropyl-O-acetylhydroquinone was accompanied by a dose-dependent arrest at the G1/S interface of the cell cycle, an impact greater than that previously reported for farnesyl-O-acetylhydroquinone (IC<sub>50</sub>=2.5 μmol/L). These new hydroquinone derivatives may have potential in cancer chemoprevention and/or therapy.
THE X-RAY IN DETERMINING THE LIMITS OF THE FRONTAL SINUS.
Authors: JOHN HAROLD PHILIP
Journal: JAMA (1902)

In the June number of the<i>Laryngoscope</i>I note the following from the pen of Dr. Jonathan Wright: "I have lately seen the frontal bone perforated and the dura mater wounded with disastrous results in a case in which the frontal sinus was lacking on that side." Dr. Howard A. Lothrop, of Harvard University, after carefully examining 250 frontal sinuses, from dissecting room material, concluded that there was no external landmark defining the superior limit of the sinus; that the external angular process of the frontal bone was not often the limit of the sinus laterally; that in the majority of cases the septum (between the sinuses) deviated to one side or the other within a range of five millimeters or even more, notwithstanding its frequent median position inferiorly; that the plane of the septum was roughly antero-posterior, passing between the anterior and posterior surfaces, but occasionally it might so
Improving Food Labeling for the Allergic Consumer
Authors: S.S. Sheth, S. Waserman, R. Kagan, R. Alizadehfar, M. Primeau, S. Elliot, Y. St. Pierre, E. Turnbull, R. Wickett, L. Joseph, L. Harada, C. Dufresne, M. Allen, S. Godefroy, A. Clarke
Journal: Journal of Allergy and Clinical Immunology (2008)
Hormone-Induced Protection against Mammary Tumorigenesis Is Conserved in Multiple Rat Strains and Identifies a Core Gene Expression Signature Induced by Pregnancy
Authors: Collin M. Blakely, Alexander J. Stoddard, George K. Belka, Katherine D. Dugan, Kathleen L. Notarfrancesco, Susan E. Moody, Celina M. D'Cruz, Lewis A. Chodosh
Journal: Cancer Research (2006)

Abstract Women who have their first child early in life have a substantially lower lifetime risk of breast cancer. The mechanism for this is unknown. Similar to humans, rats exhibit parity-induced protection against mammary tumorigenesis. To explore the basis for this phenomenon, we identified persistent pregnancy-induced changes in mammary gene expression that are tightly associated with protection against tumorigenesis in multiple inbred rat strains. Four inbred rat strains that exhibit marked differences in their intrinsic susceptibilities to carcinogen-induced mammary tumorigenesis were each shown to display significant protection against methylnitrosourea-induced mammary tumorigenesis following treatment with pregnancy levels of estradiol and progesterone. Microarray expression profiling of parous and nulliparous mammary tissue from these four strains yielded a common 70-gene signature. Examination of the genes constituting this signature implicated alterations in transforming growth factor-β signaling, the extracellular matrix, amphiregulin expression, and the growth hormone/insulin-like growth factor I axis in pregnancy-induced alterations in breast cancer risk. Notably, related molecular changes have been associated with decreased mammographic density, which itself is strongly associated with decreased breast cancer risk. Our findings show that hormone-induced protection against mammary tumorigenesis is widely conserved among divergent rat strains and define a gene expression signature that is tightly correlated with reduced mammary tumor susceptibility as a consequence of a normal developmental event. Given the conservation of this signature, these pathways may contribute to pregnancy-induced protection against breast cancer. (Cancer Res 2006; 66(12): 6421-31)