Cowden's Disease
Authors: KENNETH M. LLOYD
Journal: Annals of Internal Medicine (1963)

Case Studies1 January 1963Cowden's DiseaseA Possible New Symptom Complex with Multiple System InvolvementKENNETH M. LLOYD II, M.D., MACEY DENNIS, M.D.KENNETH M. LLOYD II, M.D., MACEY DENNIS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-136 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years an accelerated interest has been directed toward a better understanding of the rare, familial, developmental diseases. The purpose of this communication is to define an unusual symptom complex which previously has not been described. Because of the multiplicity of findings, and the ill-defined classification for this disease, it shall be referred to as "Cowden's disease," the family name of the propositus. The clinical findings include: an adenoid facies; hypoplasia of the mandible and maxilla; a high-arch palate; hypoplasia of the soft palate and uvula; microstomia; papillomatosis of the lips and oral pharynx; scrotal tongue; multiple thyroid adenomas;...References1. MOEHLIGGODBOW RCJJ: The significance of the high-arched palate. Harper Hosp. Bull. 4: 168, 1946. MedlineGoogle Scholar2. SMITHSTOWE JLFR: The Piere Robin syndrome. Pediatrics 27: 128, 1961. Google Scholar3. SAGE RA: Some interesting lesions of the tongue. Arch. Otolaryng. 43: 122, 1946. CrossrefMedlineGoogle Scholar4. HALPERINKOLASJEFFERISHUDDLESTONROBINSON VSKRSOHG: The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis and fissured tongue in 2,478 dental patients. Oral Surg. 6: 1072, 1953. CrossrefMedlineGoogle Scholar5. WALLKBLUEFARB SSM: Melkersson-Rosenthal syndrome. Arch. Derm. 84: 798, 1961. CrossrefMedlineGoogle Scholar6. 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Lloyd, II, M.D., Henry Ford Hospital, Box 166, Detroit 2, Michigan. 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