tbuckley/cabot-search huggingface dataset:
Thromboaspiration Before Intra-aortic Balloon Counterpulsation—Reply
Authors: Manesh R. Patel, Richard W. Smalling, E. Magnus Ohman
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Up-regulation of p27kip1 contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy
Authors: Jinqing Li, Cheng Zhang, Yifan Xing, Joseph S. Janicki, Masayuki Yamamoto, Xing Li Wang, Dong-Qi Tang, Taixing Cui
Journal: Cardiovascular Research (2011)

AimsNuclear factor erythroid-2-related factor 2 (Nrf2) appears to be a negative regulator of maladaptive cardiac remodelling and dysfunction; however, a potential of the Nrf2-mediated cardiac protection in diverse pathological settings remains to be determined. This study was aimed to explore the role of Nrf2 in angiotensin II (Ang II)-induced cardiac hypertrophy.
A Peptide Derived from Endostatin Ameliorates Organ Fibrosis
Authors: Yukie Yamaguchi, Takahisa Takihara, Roger A. Chambers, Kristen L. Veraldi, Adriana T. Larregina, Carol A. Feghali-Bostwick
Journal: Science Translational Medicine (2012)

A naturally occurring peptide from endostatin can inhibit fibrosis in lung and skin, even when it is already established.
The Cambridge World History of Medical Ethics
Authors: John Collins Harvey
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Factors Involved in Cardiogenesis and the Regulation of Cardiac-Specific Gene Expression
Authors: John D. Mably, Choong-Chin Liew
Journal: Circulation Research (1996)

The delineation of the mechanisms that regulate cardiac gene expression is central to our understanding of cardiac growth and development. Much progress has been made toward the identification of factors involved in tissue-restricted gene expression, especially in skeletal muscle cells. However, the mechanisms regulating the expression of cardiac-specific genes remain less well understood. Certain homeodomain proteins have been implicated in commitment to the cardiac phenotype. Among the best characterized are the murine proteins Csx, Nkx-2.5, and Nkx-2.6, related to the protein tinman, which is essential for heart formation in Drosophila . The expression of these genes precedes that of cardiac-specific genes and is therefore believed to play a critical role in the development of the heart. The GATA proteins are a family of zinc finger proteins that are also expressed early in cardiac development and may act separately from, or in concert with, the homeodomain proteins as crucial regulators of heart development. The myosin heavy and light chain genes, the actin genes, the troponin genes, and the atrial natriuretic factor and muscle creatine kinase genes have served as excellent paradigms for the study of cardiac gene expression. Although differences in cis -acting elements and their behavior in binding assays have been observed between different genes, there exist similarities that are noteworthy. In this review, we will discuss the factors involved in the regulation of cardiac-specific gene expression in an attempt to provide a better understanding of the process of cardiogenesis.
South Asian diabetic patients need more education about their illness
Authors: K. Hawthorne
Journal: BMJ (1997)

<h3>Objective</h3> To explore the recurrence of cervical artery dissection (CeAD). <h3>Methods</h3> A single-center consecutive series of 282 CeAD patients was prospectively recruited during first admission from 1995 to 2012. Patients with a follow-up of at least 1 year (n = 238) were eligible for the current analysis. All patients with clinical symptoms or signs of recurrent CeAD on ultrasound were examined by MRI. Dermal connective tissue morphology was studied in 108 (45.4%) patients. <h3>Results</h3> Median follow-up was 52 months (range 12–204 months). In all, 221 (92.8%) patients presented with monophasic CeAD, including 188 (79.0%) patients with a single CeAD event, 11 (4.6%) with simultaneous dissections in multiple cervical arteries, and 22 (9.2%) with subsequent events within a single phase of 4 weeks. Seventeen patients (7.1%) had late (&gt;1 month after the initial event) recurrent CeAD events, including 5 (2.1%) with multiple recurrences. Patients with late recurrences were younger (37.5 ± 6.9 years) than those without (43.8 ± 9.9; <i>p</i> = 0.011). Ischemic stroke occurred in 164 (68.9%) patients at first diagnosis, but only 4 of 46 (8.7%) subsequent events caused stroke (<i>p</i> &lt; 0.0001), while 19 (41.3%) were asymptomatic. Connective tissue abnormalities were found in 54 (56.3%) patients with monophasic and 8 (66.7%) with late recurrent dissections (<i>p</i> = 0.494). <h3>Conclusion</h3> Twenty-two (9.2%) patients had new CeAD events within 1 month and 17 (7.1%) later recurrences. The risk for new events was significantly higher (about 60-fold) during the acute phase than during later follow-up. Connective tissue abnormalities were not more frequent in patients with late recurrent events than in those with monophasic CeAD.
AN EXPERIMENTAL GLOMERULAR LESION CAUSED BY VENOM (CROTALUS ADAMANTEUS)
Authors: Richard M. Pearce
Journal: The Journal of Experimental Medicine (1909)

The venom of Crotalus adamanteus when administered intravenously to rabbits in properly graded doses causes lesions of the glomerulus of tile kidney which may be either hemorrhagic or exudative in character. Both types of lesion are usually associated but either one or the other may predominate. The hemorrhagic lesion, which may be confined to the glomerular tuft, or, by rupture of the latter, may involve the capsular space, is a peculiar localization of the hemorrhage so common in other parts of the body in venom intoxication. On the other hand, the exquisite exudative lesion involving usually the capsular space but sometimes limited, as in the hemorrhagic type, to the tuft itself and with little or no tubular injury, constitutes a type of experimental vascular nephritis, hitherto undescribed, which differs widely in its anatomical appearance from that due to arsenic, cantharidin and other vascular poisons. As the limitation of the lesion to the glomerulus indicates a selective action of the venom, and as the histological changes in the tuft are suggestive of gradual endothelial destruction and solution, the lesion can be explained by the action of the endotheliolytic body of crotalus venom described by Flexner and Noguchi.
INCREASED FREQUENCY OF SERUM ANTIBODIES TO CHLAMYDIA TRACHOMATIS IN INFERTILITY DUE TO DISTAL TUBAL DISEASE
Authors: DonaldE Moore, HjordisM Foy, JanetR Daling, J.Thomas Grayston, LeonR Spadoni, San-Pin Wang, Cho-Chou Kuo, DavidA Eschenbach
Journal: The Lancet (1982)
Mathematical Modeling of Tumor Growth and Metastatic Spreading: Validation in Tumor-Bearing Mice
Authors: Niklas Hartung, Séverine Mollard, Dominique Barbolosi, Assia Benabdallah, Guillemette Chapuisat, Gerard Henry, Sarah Giacometti, Athanassios Iliadis, Joseph Ciccolini, Christian Faivre, Florence Hubert
Journal: Cancer Research (2014)

Defining tumor stage at diagnosis is a pivotal point for clinical decisions about patient treatment strategies. In this respect, early detection of occult metastasis invisible to current imaging methods would have a major impact on best care and long-term survival. Mathematical models that describe metastatic spreading might estimate the risk of metastasis when no clinical evidence is available. In this study, we adapted a top-down model to make such estimates. The model was constituted by a transport equation describing metastatic growth and endowed with a boundary condition for metastatic emission. Model predictions were compared with experimental results from orthotopic breast tumor xenograft experiments conducted in Nod/Scidγ mice. Primary tumor growth, metastatic spread and growth were monitored by 3D bioluminescence tomography. A tailored computational approach allowed the use of Monolix software for mixed-effects modeling with a partial differential equation model. Primary tumor growth was described best by Bertalanffy, West, and Gompertz models, which involve an initial exponential growth phase. All other tested models were rejected. The best metastatic model involved two parameters describing metastatic spreading and growth, respectively. Visual predictive check, analysis of residuals, and a bootstrap study validated the model. Coefficients of determination were [Formula: see text] for primary tumor growth and [Formula: see text] for metastatic growth. The data-based model development revealed several biologically significant findings. First, information on both growth and spreading can be obtained from measures of total metastatic burden. Second, the postulated link between primary tumor size and emission rate is validated. Finally, fast growing peritoneal metastases can only be described by such a complex partial differential equation model and not by ordinary differential equation models. This work advances efforts to predict metastatic spreading during the earliest stages of cancer.
Hemophilia: Cyclophosphamide and Factor VIII Concentrate
Authors: RICHARD S. STEIN
Journal: Annals of Internal Medicine (1974)

Comments1 November 1974Hemophilia: Cyclophosphamide and Factor VIII ConcentrateRICHARD S. STEIN, M.D.RICHARD S. STEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-5-706_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Combinations of factor VIII concentrates and alkylating agents have met with variable success in the treatment of hemophiliacs having inhibitors of factor VIII. In some cases the anamnestic response was blocked (1, 2), and in one patient with a low titer of inhibitor, the inhibitor disappeared and repeat administration of factor VIII in the absence of further immunosuppression did not provoke the reappearance of the antibody (1). In similar but not identical circumstances, the characteristic anamnestic response to treatment has been observed (3). We report here an additional case in which an anamnestic response was blocked by...References1. STEIN R and COLMAN R: Hemophilia with factor VIII inhibitor. Elimination of the anamnestic response. Ann Intern Med 79:84-87, 1974 LinkGoogle Scholar2. LUSCHER J and EVANS R: Effective suppression of factor VIII antibody with cyclophosphamide (abstract). Blood 38:818, 1971 Google Scholar3. HRUBY M and SCHULMAN I: Failure of combined factor VIII and cyclophosphamide to suppress antibody to factor VIII in hemophilia. Blood 42:919-923, 1973 CrossrefMedlineGoogle Scholar4. KURCZYNSKI E and PENNER J: Activated prothrombin concentrate for patients with factor VIII inhibitors. N Engl J Med 291:164-167, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD S. STEIN, M.D.Affiliations: Department of Medicine Medical College of Wisconsin Milwaukee County General Hospital 8700 West Wisconsin Avenue Milwaukee, Wisconsin 53226 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImmunosuppressive Treatment in Haemophiliacs with Inhibitors to Factor VIII and Factor IX 1 November 1974Volume 81, Issue 5Page: 706-707KeywordsAntibody productionCyclophosphamideHemophilia ePublished: 1 December 2008 Issue Published: 1 November 1974 PDF downloadLoading ...
Tumor Necrosis Factor- α − 308 Promoter Gene Polymorphism and Increased Tumor Necrosis Factor Serum Bioactivity in Farmer's Lung Patients
Authors: BERNHARD M. SCHAAF, ULRIKE SEITZER, VERA PRAVICA, SVEN P. ARIES, PETER ZABEL
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Hypersensitivity pneumonitis (HP) represents an immunologic reaction of the pulmonary parenchyma to an inhaled agent. Since tumor necrosis factor (TNF)- α is thought to be involved in the pathogenesis of HP, and polymorphisms in the TNF genes have been associated with variations in the production of TNF- α , we investigated the serum bioactivity and genotype of TNF in HP. TNF bioactivity was measured after hay dust challenge in eight patients with farmer's lung (Group A) and in 12 healthy, sensitized (antibody-positive) controls (Group B). Genotyping for the − 308 TNF- α promoter polymorphism and the TNF- β intron 1 gene polymorphism was performed in 20 patients with farmer's lung, 25 patients with pigeon breeder's lung, and 216 controls. TNF bioactivity increased in Group A at 4 to 10 h after hay dust challenge, but not in Group B (p < 0.05). The frequency for the TNFA2 allele, a genotype associated with high TNF- α production in vitro, was significantly higher in farmer's lung patients (frequency [f] = 0.43, p = 0.0012) than in controls (f = 0.19) or patients with pigeon breeder's lung (f = 0.16). Genotyping for TNF- β revealed no significant abnormalities. Thus, increased production of TNF- α after hay contact, and a genetic predisposition to TNF- α production, are implicated in the pathogenesis of alveolitis in farmer's lung.
Regulated Insulin Delivery From Human Epidermal Cells Reverses Hyperglycemia
Authors: Jun Tian, Pedro Lei, Suzanne G Laychock, Stelios T Andreadis
Journal: Molecular Therapy (2008)

Alternative insulin therapies are being sought that will provide euglycemic control for people with diabetes mellitus. The epidermis is a self-renewing tissue that is easily accessible and can provide large numbers of autologous cells that can be used for generating insulin-secreting skin substitutes. Lentiviral vectors have been engineered to produce a fusion protein between the furin-cleavable proinsulin and the self-dimerization mutant of FK506-binding protein to yield bioactive insulin in keratinocytes; this insulin is released as a response to exogenous administration of a small organic molecule, rapamycin. The engineered keratinocytes retained normal morphology and grew in a manner similar to lentiviral-treated control cells. Epidermal keratinocytes in culture and in stratified bioengineered epidermis released insulin within 30 minutes after addition of rapamycin, and secretion slowed or stopped within 2–3 hours after removal of the inducing agent. When the cells were implanted into athymic mice that had been rendered diabetic with streptozotocin (STZ), insulin was detected in the plasma within 1 hour after addition of rapamycin. Concomitantly, serum glucose decreased to normal levels even in diabetic animals with severe hyperglycemia. Repeated rapamycin administration yielded similar results. These experiments provide proof-of-concept that insulin released from the skin in a regulatable manner can reverse hyperglycemia. Alternative insulin therapies are being sought that will provide euglycemic control for people with diabetes mellitus. The epidermis is a self-renewing tissue that is easily accessible and can provide large numbers of autologous cells that can be used for generating insulin-secreting skin substitutes. Lentiviral vectors have been engineered to produce a fusion protein between the furin-cleavable proinsulin and the self-dimerization mutant of FK506-binding protein to yield bioactive insulin in keratinocytes; this insulin is released as a response to exogenous administration of a small organic molecule, rapamycin. The engineered keratinocytes retained normal morphology and grew in a manner similar to lentiviral-treated control cells. Epidermal keratinocytes in culture and in stratified bioengineered epidermis released insulin within 30 minutes after addition of rapamycin, and secretion slowed or stopped within 2–3 hours after removal of the inducing agent. When the cells were implanted into athymic mice that had been rendered diabetic with streptozotocin (STZ), insulin was detected in the plasma within 1 hour after addition of rapamycin. Concomitantly, serum glucose decreased to normal levels even in diabetic animals with severe hyperglycemia. Repeated rapamycin administration yielded similar results. These experiments provide proof-of-concept that insulin released from the skin in a regulatable manner can reverse hyperglycemia.
Marked increase in C-C chemokine gene expression both in human and mouse mast cell transcriptomes after FcεR I cross-linking
Authors: Hirohisa Saito, Toshiharu Nakajima, Mamoru Yoshikawa, Kenji Matsumoto, Akira Akasawa, Gozo Tsujimoto, Hiroichi Nagai, Hiroshi Matsuda
Journal: Journal of Allergy and Clinical Immunology (2002)
Clinical Evaluation of Push-Type Enteroscopy
Authors: M. Pennazio, A. Arrigoni, M. Risio, M. Spandre, F. P. Rossini
Journal: Endoscopy (1995)

Background and Study Aims: Endoscopic exploration of the small bowel is potentially of prime importance in studying gastrointestinal bleeding of obscure origin, diarrhea and malabsorption, neoplasia, and other clinical conditions, but the method is still problematic because of the limited efficacy of sonde-type enteroscopes. This study evaluates the diagnostic yield of two push-type enteroscopes fitted with tip deflection and a biopsy channel.
Synergistic Copathogens — HIV-1 and HSV-2
Authors: Lawrence Corey
Journal: New England Journal of Medicine (2007)

The variability in both the clinical progression and transmission of human immunodeficiency virus (HIV) infection has prompted a search for cofactors influencing replication of the virus. Although it is clear that host immune and genetic factors, as well as the replication kinetics of particular viral strains, influence the progression of HIV disease, a variety of exogenously acquired infectious agents also appear to influence the pace of HIV replication, the destruction of CD4+ T cells, and HIV transmission to infants and sexual partners. Transient bursts of HIV replication occur after vaccination and during episodes of acute systemic infection. More persistent elevations . . .
Dynamics of Interatrial Shunting in Children with Obstruction of the Tricuspid and Pulmonic Valves
Authors: AARON R. LEVIN, MADISON S. SPACH, RAMON V. CANENT, JOHN P. BOINEAU
Journal: Circulation (1970)

The interatrial pressure-flow dynamics in patients with right-to-left shunting at the atrial level in the presence of right heart obstruction were studied. In tricuspid atresia most of the right-to-left gradient occurred during right atrial systole. This gradient, as well as the cineangiocardiograms, indicated that almost all systemic venous return was transferred from the right to the left atrium through the interatrial communication during right atrial contraction. Cine studies also suggesed that right atrial systole (1) contributed significantly to left ventricular filling and (2) produced regurgitant venous flow, especially into the hepatic veins. In two patients with secundum atrial defect and associated marked pulmonic valve stenosis, bidirectional shunting at the atrial level was defined by pressure gradient and cine and dye-dilution curve technics. The right-to-left gradient and shunt occurred during ventricular diastole with accentuation of this gradient by atrial contraction; the left-to-right interatrial flow and gradient occurred during ventricular systole when both A-V valves were closed. These studies indicate that, in the presence of an interatrial communication, increasing degrees of right heart obstruction not only produce right-to-left shunting but (1) do so primarily by right-to-left flow across the interatrial communication during ventricular diastole and (2) with complete right atrial obstruction, right atrial contraction plays a dominant role in the transfer of systemic venous return to the left atrium.
Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes
Authors: Ralph Tiedt, Jörn Coers, Sandra Ziegler, Adrian Wiestner, Hui Hao-Shen, Caroline Bornmann, Johannes Schenkel, Svetlana Karakhanova, Frederic J. de Sauvage, Carl W. Jackson, Radek C. Skoda
Journal: Blood (2008)
Detection and management of hypertension in general practices in north west London.
Authors: K H Kurji, A P Haines
Journal: BMJ (1984)

An examination of the practice notes and attached correspondence of 900 patients aged 30 to 65 years in a random sample of 18 general practice in north west London showed that 340 (47%) of 716 patients consulting in a 10 year period had no blood pressure readings in their records. The blood pressure was equal to or above 160 mm Hg systolic or 95 mm Hg diastolic, or both, in 115 (31%) of those whose blood pressures were recorded; 18 (16%) of these were not followed up. Seventy four patients were being treated for hypertension. Diuretics were the most commonly prescribed drugs. Treatment was started after one blood pressure reading in 34 (46%). Nine of those who had an initial raised blood pressure reading were normotensive on follow up. A further 14 patients had subsequent raised blood pressure readings but were not treated. Sixty one (69%) of the 88 patients with hypertension did not have a blood pressure recording after diagnosis for one or more periods exceeding 12 months. Of 84 hypertensive patients with complete records, 62 (74%) apparently had had no physical examination performed by the general practitioner and 61 (72%) did not seem to have had any investigations initiated by the general practitioners. Fifteen (35%) of 43 patients taking oral contraceptive pills apparently had no blood pressure recordings during the time they were taking these. The results of this study suggest that there are still deficiencies in the detection and management of hypertension in general practice.