A Guide to Disorders of Hemostasis
Authors: MEHRAN GOULIAN
Journal: Annals of Internal Medicine (1966)

Diagnosis and Treatment1 October 1966A Guide to Disorders of HemostasisMEHRAN GOULIAN, M.D.MEHRAN GOULIAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-782 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe subject of hemostasis has repelled many clinicians largely because of its reputation for confusion and inconsistency. Recent advances in the scientific basis of hemostasis have ended much pointless controversy of the past and improved our ability to understand and solve practical problems. The purpose here is to outline a practical approach to clinical hemostasis based on present concepts of hemostatic mechanisms. No attempt is made to be exhaustively complete and sources for more detailed information are indicated. Selection of material is influenced by recent shifts in emphasis due to newer information and, above all, by what is most useful...References General References1. SCHULMAN I: Vascular factors in hemostasis. Ann. Rev. Med. 14: 339, 1963. CrossrefMedlineGoogle Scholar2. JOHNSONMONTOREBUCK SARWJW (editors): Blood Platelets. Henry Ford Hospital International Symposium. Little, Brown and Co., Boston, 1961. Google Scholar3. SPAET TH: The platelet in hemostasis. Ann. N. Y. Acad. Sci. 115: 31, 1964. CrossrefMedlineGoogle Scholar4. SHARP AA: Present status of platelet aggregation. New Eng. J. Med. 272: 89, 1965. CrossrefMedlineGoogle Scholar5. MARCUSZUCKER AJMB: The Physiology of Blood Platelets. Grune & Stratton, Inc., New York, 1965. Google Scholar6. LÜSCHER EF: Biochemistry of blood platelets and thrombus formation. Series Haematologica supplement to Scand. J. Haemat. 10: 76, 1965. Google Scholar7. HARDISTY RM: The haemostatic process, in Lectures on Haematology, edited by HAYHOE, F. G. J. Cambridge University Press, Cambridge, 1960, pp. 179-199. Google Scholar8. MERSKEYMARCUS CAJ: Lipids, blood coagulation and fibrinolysis. Ann. Rev. Med. 14: 323, 1963. CrossrefMedlineGoogle Scholar9. POOL JG: Thromboplastin formation. Ann. Rev. Med. 15: 215, 1964. CrossrefMedlineGoogle Scholar10. GASTON LW: The blood-clotting factors. New Eng. J. Med. 270: 236, 290, 1964. CrossrefMedlineGoogle Scholar11. MACFARLANE RG: An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature (London) 202: 498, 1964. CrossrefMedlineGoogle Scholar12. DAVIERATNOFF EWOD: The proteins of blood coagulation, in The Proteins, edited by NEURATH, H. Academic Press, New York, 1965. Google Scholar13. DUCKERT F: The fibrin stabilizing factor (FSF). Series Haematologica supplement to Scand. J. Haemat 7: 58, 1965. Google Scholar14. SHERRYFLETCHERAIKJAERSIG SAPN: Fibrinolysis and fibrinolytic activity in man. Physiol. Rev. 39: 343, 1959. CrossrefMedlineGoogle Scholar15. VON KAULA KN: Chemistry of Thrombolysis in Human Fibrinolytic Enzymes. Charles C Thomas, Publisher, Springfield, Ill., 1963. Google Scholar16. MACFARLANE RG: The development of ideas on fibrinolysis. Brit. Med. Bull. 20: 173, 1964. CrossrefMedlineGoogle Scholar17. STAFFORD JL: Fibrinolysis and intrinsic haemostasis. Ibid., p. 179. Google Scholar18. SHARP AA: Pathological fibrinolysis. Ibid., p. 240. Google Scholar19. JOHNSONNEWMAN AGJ: The fibrinolytic system in health and disease. Seminars Hemat. 1: 401, 1964. MedlineGoogle Scholar20. SHERRY S: Present concept of the fibrinolytic state. Series Haematologica supplement to Scand. J. Haemat. 7: 70, 1965. Google Scholar21. PECHET L: Fibrinolysis. New Eng. J. Med. 273: 966, 1024, 1965. CrossrefMedlineGoogle Scholar22. SILVERSTEIN A: Management of neurologic complications of hemophilia, in The Hemophilias, International Symposium, Washington, edited by BRINKHOUS, K. M. University of North Carolina Press, Chapel Hill, 1964. Google Scholar23. BARROWGRAHAM EMJB: Von Willebrand's disease, in Progress in Hematology, vol. 4, edited by MOORE, C. V., BROWN, E. B. Grune & Stratton, Inc., New York, 1964, p. 203. Google Scholar24. RAPAPORTPROCTORPATCHYETTRA SIRPMJM: The mode of inheritance of PTA deficiency: evidence for the existence of major PTA deficiency and minor PTA deficiency. Blood 18: 149, 1961. CrossrefMedlineGoogle Scholar25. BALDINIEBBE MS: Platelet disorders and their management. Med. Clin. N. Amer. 46: 1349, 1962. CrossrefMedlineGoogle Scholar26. GUNZ FW: Hemorrhagic thrombocythemia: a critical review. Blood 15: 706, 1960. CrossrefMedlineGoogle Scholar27. WILLOUGHBYCROUCH MLS: An investigation of the haemorrhagic tendency in renal failure. Brit. J. Haemat. 7: 315, 1961. CrossrefMedlineGoogle Scholar28. RATNOFF OD: Hemostatic mechanisms in liver disease. Med. Clin. N. Amer. 47: 721, 1963. CrossrefMedlineGoogle Scholar29. DOUGLAS AS: Anticoagulant Therapy. Blackwell Scientific Publications, Oxford, 1962. Google Scholar30. MCKAY DG: Disseminated Intravascular Coagulation. An Intermediary Mechanism of Disease. Harper & Row, New York, 1965. Google Scholar31. KOLLER F: Clinical and genetic aspects of coagulopathies with special emphasis on generalized intravascular clotting. Ann. Intern. Med. 62: 744, 1965. LinkGoogle Scholar32. VERSTRAETEVERMYLENVERMYLENVANDENBROECKE MCJJ: Excessive consumption of blood coagulation components as a cause of hemorrhagic diathesis. Amer. J. Med. 38: 899, 1965. CrossrefMedlineGoogle Scholar33. RODRIGUEZ-ERDMANN F: Bleeding due to increased intravascular blood coagulation: hemorrhagic syndromes caused by consumption of blood clotting factors (consumption-coagulopathies). New Eng. J. Med. 273: 1370, 1965. CrossrefMedlineGoogle Scholar34. MARGOLIUSJACKSONRATNOFF ADPOD: Circulating anticoagulants: a study of 40 cases and a review of the literature. Medicine (Bait.) 40: 145, 1961. CrossrefMedlineGoogle Scholar35. PACHTERNEBLETTTRUANT MRTRJP: Bleeding, platelets, and macroglobulinemia. Amer. J. Clin. Path. 31: 467, 1959. CrossrefMedlineGoogle Scholar36. BORCHGREVINK CF: Platelet adhesiveness in vivo in patients with bleeding disorders. Acta Med. Scand. 170: 231, 1961. CrossrefGoogle Scholar37. SALZMAN EW: Measurement of platelet adhesiveness. A simple in vitro technique demonstrating an abnormality in von Willebrand's disease. J. Lab. Clin. Med. 62: 724, 1963. MedlineGoogle Scholar38. HICKSPITNEY NDWR: A rapid screening test for disorders of thromboplastin generation. Brit. J. Haemat. 3: 227, 1957. CrossrefMedlineGoogle Scholar39. O'REILLYAGGELERHOAGLEONG RAPMMSL: Studies on the coumarin anticoagulant drugs: the assay of warfarin and its biologic application. Thromb. Diath. Haemorrh. 8: 82, 1962. Google Scholar40. GOULIANBECK MWS: The partial thromboplastin time test. Amer. J. Clin. Path. 35: 97, 1965. CrossrefGoogle Scholar41. FLUTE PT: The assessment of fibrinolytic activity in the blood. Brit. Med. Bull. 20: 195, 1964. CrossrefMedlineGoogle Scholar42. RATNOFF OD: The therapy of hereditary disorders of blood coagulation. Arch. Intern. Med. (Chicago) 112: 92, 1963. MedlineGoogle Scholar43. ROBERTSGRAHAMWEBSTERPENICK HRJBWPG: Plasma transfusion therapy in hemophilia, in The Hemophilias. International Symposium, Washington. University of North Carolina Press, Chapel Hill, 1964, p. 323. Google Scholar44. MCMILLANDIAMONDSURGENOR CWLKDM: Treatment of classic hemophilia: the use of fibrinogen rich in factor VIII for hemorrhage and surgery. New Eng. J. Med. 265: 224, 1961. CrossrefGoogle Scholar45. POOLSHANNON JGAE: Production of high-potency concentrates of antihemophilic globulin in a closed-bag system: assay in vitro and in vivo. New Eng. J. Med. 273: 1443, 1965. CrossrefMedlineGoogle Scholar46. CORNULARRIEUCAENBERNARD PMJJJ: Transfusion studies in von Willebrand 's disease: effect on bleeding time and factor VIII. Brit. J. Haemat. 9: 189, 1963. CrossrefMedlineGoogle Scholar47. BIGGSMATTHEWS RJ: The treatment of hemorrhage in von Willebrand's disease and the blood level of factor VIII (AHG). Ibid., p. 203. Google Scholar48. MCNICOLDOUGLAS GPAS: Epsilonaminocaproic acid and other inhibitors of fibrinolysis. Brit. Med. Bull. 20: 233, 1964. CrossrefMedlineGoogle Scholar49. MERSKEYJOHNSONPERTWOHL CAGJHH: Pathogenesis of fibrinolysis in defibrination syndrome: effect of heparin administration. Blood 24: 701, 1964. CrossrefMedlineGoogle Scholar BIGGSMACFARLANE RRG: Human Blood Coagulation and its Disorders, 3rd ed. Blackwell Scientific Publications, Oxford, 1962. Google Scholar BIGGSMACFARLANE RRG, (editors): Treatment of Haemophilia and Other Coagulation Disorders. Blackwell Scientific Publications, Oxford, 1966. Google Scholar HARDISTYINGRAM RMGI: Bleeding Disorders, Investigation and Management. Blackwell Scientific Publications, Oxford, 1965. Google Scholar HOUGIE C: Fundamentals of Blood Coagulation in Clinical Medicine. McGraw Hill Book Co., New York, 1963. Google Scholar JOHNSONGREENWALT SATJ: Coagulation and Transfusion in Clinical Medicine. Little, Brown and Co., Boston, 1965. Google Scholar RATNOFF OD: Bleeding Syndromes. Charles C Thomas, Publisher, Springfield, Ill., 1960. Google Scholar RATNOFF OD: The blood clotting mechanism and its disorders. DM, November, 1965. Google Scholar SALZMANBRITTEN EWA: Hemorrhage and Thrombosis. A Practical Clinical Guide. Little, Brown and Co., Boston, 1965. Google Scholar SEEGARS WH: Prothrombin. Harvard University Press, Cambridge, 1962. CrossrefGoogle Scholar STEFANINIDAMESHEK MW: The Hemorrhagic Disorders. 2nd ed. Grune & Stratton, Inc., New York, 1962. Google Scholar TOCANTINSKAZAI LMLA (editors): Blood Coagulation. Hemorrhage and Thrombosis. Methods of Study. 2nd ed. Grune & Stratton, Inc., New York, 1964. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MEHRAN GOULIAN, M.D.Affiliations: Boston, MassachusettsFrom the Department of Medicine, Harvard Medical School, and the Hematology Research Laboratory of the Medical Service of the Massachusetts General Hospital, Boston, Mass.This study was supported by grants AM-04501 and HE-04610, National Institute of Arthritis and Metabolic Diseases, and the National Heart Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Mehran Goulian, M.D., Department of Biochemistry, Stanford University School of Medicine, Palo Alto, Calif. 94304. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPlasma thromboplastin antecedent deficiencyFibrinolysis and Hemorrhage in a Fatal Case of Heat Stroke 1 October 1966Volume 65, Issue 4Page: 782-796KeywordsArthritisHeart diseasesHematology and oncologyHemostasisHemostaticsHospital medicineLongitudinal studiesMedical servicesMetabolic disordersResearch laboratories ePublished: 1 December 2008 Issue Published: 1 October 1966 PDF downloadLoading ...