Creatininemia Versus Uremia
Authors: JOHN B. DOSSETOR
Journal: Annals of Internal Medicine (1966)

Diagnosis and Treatment1 December 1966Creatininemia Versus UremiaThe Relative Significance of Blood Urea Nitrogen and Serum Creatinine Concentrations in AzotemiaJOHN B. DOSSETOR, M.D., PH.D., F.A.C.P., F.R.C.P. (C)JOHN B. DOSSETOR, M.D., PH.D., F.A.C.P., F.R.C.P. (C)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-6-1287 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe terms uremia and azotemia are applied to acute or chronic conditions in which the blood concentration of nitrogenous end products rises. The terms are otherwise poorly defined. Nitrogen retention usually occurs when the renal function is less than 30% of normal. Recently, progressive renal dysfunction has been graded as [1] diminished renal reserve, [2] renal insufficiency, [3] renal failure, and [4] uremia (Strauss and Welt (1) 1963), but each grade overlaps others.Although urea is present in greatest amount, errors can occur when increased urea concentration is accepted as synonymous with the degree of renal dysfunction. Myers, Fine, and...References1. STRAUSSWELT MBLG (editors): Diseases of the Kidney. Little, Brown and Co., Boston, 1963. Google Scholar2. MYERSFINELOUGH VCMSEG: The significance of uric acid, urea and creatinine of blood in nephritis. Arch. Intern. Med. (Chicago) 17: 570, 1916. CrossrefGoogle Scholar3. MYERSKILLIAM VCJA: The prognostic value of the creatinine in the blood in nephritis. Proc. Soc. Exp. Biol. Med. 16: 41, 1918. CrossrefGoogle Scholar4. MÖLLERMCINTOSHVAN SLYKE EJFDD: Studies on urea excretion. Relationship between urine volume and the rate of urea excretion by normal adults. J. Clin. Invest. 6: 427, 1928. 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