Ro 15-1788 and Hepatic Failure
Authors: L. R. SUTHERLAND
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 January 1988Ro 15-1788 and Hepatic FailureL. R. SUTHERLAND, G. Y. MINUKL. R. SUTHERLANDSearch for more papers by this author, G. Y. MINUKSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-1-158_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently, Ro 15-1788, a GABA-benzodiazepine receptor antagonist, was reported to be effective in the management of adults with chronic liver disease and hepatic encephalopathy (1, 2). To our knowledge, the use of this agent has not been reported in patients with fulminant hepatic failure.A 30-year-old woman was hospitalized with nausea and abdominal discomfort after an acetaminophen overdose (15 g). Laboratory results included serum bilirubin, 67 μM/L (normal, 3 to 20) and alanine aminotransferase, 2598 U/L (normal, 0 to 36). The prothrombin time was 59.3s (control, 11 to 13). Forty-eight hours later the patient became confused, then...References1. SCOLLO-LAVIZZARI G and STEINMANN E. Reversal of hepatic coma by benzodiazepine antagonist (Ro 15-1788) [Letter]. Lancet. 1985;1:1324. CrossrefGoogle Scholar2. BANSKY G, MEIER P, and ZIEGLER W. Reversal of hepatic coma by benzodiazepine antagonist (Ro 15-1788) [Letter]. Lancet. 1985;1:1324-5. Google Scholar3. CANALESE J, GIMSON A, and DAVIS C. Controlled trial of dexamethasone and mannitol for the cerebral edema of fulminant hepatic failure. Gut. 1982;23:625-9. CrossrefMedlineGoogle Scholar4. BARALDI M, ZENEROLI M, and VENTURA E. Supersensitivity of benzodiazepine receptors in hepatic encephalopathy due to fulminant hepatic failure in the rat: reversal by a benzodiazepine antagonist. Clin Sci. 1984;67:167-75. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: L. R. SUTHERLAND; G. Y. MINUKAffiliations: Department of Medicine The University of Calgary Calgary, Alberta, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Role of Natural Benzodiazepines Receptor Ligands in Hepatic EncephalopathyFlumazenil for hepatic encephalopathy grade III and IVa in patients with cirrhosis: An italian multicenter double-blind, placebo-controlled, cross-over studyFlumazenil in cirrhotic patients in hepatic coma: A randomized double-blind placebo-controlled crossover trialRelationship between plasma benzodiazepine receptor ligand concentrations and severity of hepatic encephalopathyHepatic EncephalopathyNeurochemical studies of hepatic encephalopathyPathophysiology and clinical basis of prevention and treatment of complications of chronic liver diseaseFlumazenil: A new benzodiazepine antagonistFlumazenil in the treatment of portal systemic encephalopathy —an overviewAlterations of GABA-A and dopamine D-2 brain receptors in dogs with portal-systemic encephalopathyFlumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbitSupersensitivity of GABA-A receptors in hepatic encephalopathyBenzodiazepine Antagonist in the Treatment of Human Hepatic EncephalopathyNeurotransmission in Hepatic EncephalopathyFlumazenil: Potential implications for hepatic encephalopathyCortical benzodiazepine receptor binding in a rabbit model of hepatic encephalopathy: The effect of Triton X-100 on receptor solubilizationThe γ-Aminobutyric Acid A (GABAA) Receptor Complex and Hepatic Encephalopathy Some Recent AdvancesE. Anthony Jones, MD, Phil Skolnick, PhD, Sergio H. Gammal, MD, Anthony S. Basile, PhD, Kevin D. Mullen, MBStudies of Central and “Peripheral-Type” Benzodiazepine Receptors in Autopsied Brain Tissue from Cirrhotic Patients with Hepatic EncephalopathyRo 15–1788 Kinetics are Markedly Impaired in Cirrhotic Patients.Treatment Of Hepatic Encephalopathy With The Benzodiazepine Antagonist FlumazenilIMPROVEMENT OF HEPATIC ENCEPHALOPATHY TREATED WITH FLUMAZENIL 1 January 1988Volume 108, Issue 1Page: 158-158KeywordsAcute liver failureAlanine aminotransferaseBilirubinBrain diseasesChronic liver diseaseNauseaProthrombin timeResearch laboratories ePublished: 1 December 2008 Issue Published: 1 January 1988 PDF downloadLoading ...