tbuckley/cabot-search huggingface dataset:
Total Cholesterol and Death from Coronary Heart Disease in Older Persons
Authors: Charles M. Grossman
Journal: Annals of Internal Medicine (1998)

Letters1 February 1998Total Cholesterol and Death from Coronary Heart Disease in Older PersonsCharles M. Grossman, MDCharles M. Grossman, MDPortland, OR 97205Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-3-199802010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:There are several problems with Corti and colleagues' attempt to correlate death from coronary heart disease and cholesterol levels in older persons [1]. First, calculations from crude mortality rates, requiring adjustments to achieve results that are the opposite of the raw data, can hardly be called observational evidence (as is done twice in the Discussion section). Second, statistical significance occurs only when the 44 deaths that occurred in the first year were excluded from the analysis. The authors collected these data in accordance with their own experimental design. The authors then argue that persons in the last ...References1. Corti MC, Guralnik JM, Salive ME, Harris T, Ferrucci L, Glynn RJ, et al. Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons. Ann Intern Med. 1997; 126:753-60. Google Scholar2. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, McFariane PW, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study. N Engl J Med. 1995; 333:1301-7. Google Scholar3. Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG, et al. Effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. 1996; 335:1001-9. Google Scholar4. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease. The Scandinavian Simvastatin Survival Study (4S). Lancet. 1994; 344:1383-9. Google Scholar5. Grossman CM. Cholesterol reduction, heart disease, and mortality [Letter]. Ann Intern Med. 1997; 126:661. Google Scholar Author, Article, and Disclosure InformationAffiliations: Portland, OR 97205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1998Volume 128, Issue 3Page: 242KeywordsCholesterolCoronary heart diseaseDeath ratesLongitudinal studiesMortalityResearch designSerum albumin Issue Published: 1 February 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Time to face up to the locums scandal
Authors: F. Godlee
Journal: BMJ (2010)

“On rare occasions single catastrophic errors rightly lead to a complete review of a healthcare service,” write Paul Cosford and Justyn Thomas this week (doi:10.1136/bmj.c3194). They have in mind the death of David Gray from an overdose of diamorphine given by German based locum Daniel Ubani. Without absolving Ubani of responsibility, they are damning of the system that allowed a doctor who had previously failed an English language test, had never worked in the UK, and did not practise primary care in Germany, to fly in one evening and work unsupervised the following day. 

They call for changes, including letting the General Medical Council assess competence and …
Re: Increased Virus Shedding With Aspirin Treatment of Rhinovirus Infection
Authors: William J. Mogabgab
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In the recent report by Stanley et al (231:1248, 1975) rhinovirus types 21 or 25 were recovered more often from infected volunteers receiving 0.6 gm of aspirin three times daily for five days than from placebo-treated and also infected controls. Because of this, we report the following. Rhinovirus, type 1A (third passage in WI-38 cells; 50% tissue culture infective dose, 10<sup>4.5</sup>/ml) was inoculated into nonimmune young adults, 0.75 ml in each nostril. Pharyngeal washings for virus isolation were obtained on days 1, 2, and 3. When symptoms of an upper respiratory tract illness began, volunteers were given aspirin or placebo, 0.6 gm four times daily. In those receiving medication from day 1, there were 7 of 18 rhinovirus-positive specimens in the aspirin group and 9 of 18 in the placebo group on days 2 and 3. When treatment was begun on day 2, five of
Death of a Blow-up Doll
Authors: Brian J. Secemsky
Journal: Annals of Internal Medicine (2013)

On Being a DoctorDecember 3, 2013Death of a Blow-up DollBrian J. Secemsky, MDBrian J. Secemsky, MDFrom University of California, San Francisco, San Francisco, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-11-201312030-00017 Audio Reading - “Death of a Blow-up Doll” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Death of a Blow-up Doll," by B.J. Secemsky.. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A few weeks ago, I cried during a scene from Lars and the Real Girl, a dark comedy starring Ryan Gosling about an unconventional man and his even more unconventional relationship with an inflatable sex doll. The tears started pouring as the doll, found “unresponsive” by Gosling's character, was rushed to the hospital where—you guessed it—she “died.” The last time I cried over a movie was during The Babe, a 1992 biography describing the tumultuous life of Babe Ruth. I was 7 years old.As a resident physician training in internal medicine, I have encountered countless tragic episodes of death ...Reference1. Hughes PH, Brandenburg N, Baldwin DC, Storr CL, Williams KM, Anthony JC, et al. Prevalence of substance use among US physicians. JAMA. 1992;267:2333-9. [PMID: 1348789] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of California, San Francisco, San Francisco, California.Corresponding Author: Brian J. Secemsky, MD, General Medical Clinic, San Francisco General Hospital, 1001 Potrero Avenue 1M3, San Francisco, CA 94110; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Death of a Blow-up Doll” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Death of a Blow-up Doll," by B.J. Secemsky.. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics December 3, 2013Volume 159, Issue 11Page: 791KeywordsBehaviorEmotionsFoodHealth care providersPsychiatry and mental healthSportsSubstance abuse ePublished: 3 December 2013 Issue Published: December 3, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
P3-07-05: Nomogram Incorporating SLN Metastasis Size Provides the Most Accurate Prediction of Non-SLN Involvement in Breast Cancer Patients.
Authors: SM Gainer, EA Mittendorf, KK Hunt, RL Bassett, M Yi, F Meric-Bernstam, MI Ross, GV Babiera, HM Kuerer, AS Caudle, RF Hwang
Journal: Cancer Research (2011)

Abstract Introduction: The finding of metastatic disease in the axillary nodes remains an important factor that guides adjuvant therapy decisions in breast cancer. The value of completion axillary lymph node dissection (ALND) may not be the same in all patients and determining the risk of non-SLN involvement can be a guide in surgical decision making. We recently developed a nomogram that incorporates the maximum SLN metastasis size to predict non-SLN axillary involvement (Mittendorf et al., Ann Surgery 2011,in press). The purpose of this study was to compare the accuracy of this nomogram to another widely used nomogram that does not include SLN metastasis size. Methods: We queried a prospective breast cancer database for patients with clinically negative nodes undergoing sentinel node biopsy who did not receive neoadjuvant therapy. We identified 431 patients with invasive breast cancer treated from 1996 to 2007 who had a positive SLN and underwent completion ALND. We evaluated clinicopathologic data including histology, multifocality, nuclear grade, pathologic tumor size, number of SLNs recovered, number of positive SLNs, maximum SLN metastasis size, presence of extranodal extension, hormone receptor status, and presence of lymphovascular invasion. Data were entered into our nomogram and the nomogram that does not include SLN metastasis size. The accuracy of the 2 nomograms in predicting non-SLN axillary metastasis was compared in all patients and in subgroups of patients based on burden of disease in the SLN. Results: For the entire cohort of 431 women with positive SLNs, our SLN size nomogram was more accurate in the detection of non-SLN disease (area under the receiver operating characteristic curve [AUC] 78.3% vs. 72.4%, p=0.01). Whether or not SLNs were subjected to frozen section did not influence the relative accuracies of the 2 nomograms. When patients were analyzed by burden of disease in the SLNs, our SLN size nomogram was more accurate in predicting non-SLN disease in patients with macrometastases in the SLN (AUC 77.3% vs. 70.3%, p=0.008). There was no significant difference in the accuracy of the 2 nomograms for patients with isolated tumor cells or micrometastases in the SLNs. Conclusions: Our nomogram incorporating SLN metastasis size with other clinicopathologic factors is the most accurate predictor of the risk of non-SLN metastasis in patients with a positive SLN. The SLN size nomogram is highly accurate in women with macrometastases, who may benefit the most from completion ALND. Using a nomogram with SLN metastasis size can provide the most accurate information for patient counseling and surgical decision making. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-07-05.
Iron and Diabetes Revisited
Authors: Sudhir V. Shah, Vivian A. Fonseca
Journal: Diabetes Care (2011)

Iron is the most abundant transitional metal in the body. It has long been recognized that iron overload can increase the risk of diabetes, particularly in iron-overload states such as hemochromatosis and recurrent transfusions in diseases like thalassemia. Furthermore, a large body of epidemiological evidence suggests that an increase in dietary iron (as heme, mainly from meat and meat products) is associated with an increased risk of diabetes (1). In contrast, iron deficiency (over time one of the most common nutritional deficiencies in the world) may lower the risk of diabetes. Indeed, it has been suggested that recurrent phlebotomy may protect against diabetes (2), although there are no large multicenter, randomized controlled trials to support this hypothesis. In addition, iron has been implicated in the pathogenesis of renal disease including diabetic nephropathy (1).

Two articles in this issue of Diabetes Care add to this evidence and report that prepregnancy dietary heme iron intake is associated with an increased risk of diabetes. The association remains significant even after adjustment for a variety of factors known to be associated with gestational diabetes mellitus (GDM). Bowers et al. (3) studied participants in the Nurses' Health Study which has a robust dataset and fairly reliable information on …
The Coal Miner and His Doctor
Authors: John Pemberton
Journal: New England Journal of Medicine (1955)

"THE present practices of medicine in the coal fields on a contract basis cannot be supported. They are synonymous with many abuses and they are undesirable and in many instances deplorable."These blunt statements appeared in the report, published in 1947, of a medical survey of the bituminous-coal industry instigated by the federal Government and conducted by a commission headed by Rear Admiral Joel T. Boone.1 The survey was one of the results of the 1946 coal strike. Another was the creation of the United Mine Workers of America Welfare and Retirement Fund for bituminous-coal miners and their dependents, financed . . .
Commercial Hair Analysis: Science or Scam?
Authors: George Hickok
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The publication of the recent article entitled "Commercial Hair Analysis: Science or Scam?" by Dr Stephen Barrett<sup>1</sup>surely constitutes a new low for<i>JAMA</i>. Space does not permit a point by point critique, but a few comments should be mentioned: Barrett ignores the literature published since 1974 showing that laboratories have learned how to manage or use to their advantage each of the seven items listed as problems.<sup>2</sup>In fact, laboratories for commercial hair analysis in existence in 1974 had overcome these problems at that time. Sixty percent of the business of Doctor's Data Inc, the oldest and largest laboratory for hair analysis, comes from physicians—many board certified in their specialty! Barrett infers that there is great discrepancy when two results from the same laboratory vary between normal and high, or normal and low. He does not explain that this can be by only one
Good Ole Boys on Target With Cost-effective Spittoons
Authors: Darren Lisse
Journal: JAMA (1985)

<h3>To the Editor.—</h3> For some time there has been controversy regarding the documentation of progress in the resolution of Bell's palsy. Those of us who practice medicine south of the Mason-Dixon line would like to share with our Northern brethren a newly discovered method to solve this dilemma. Recently we treated an electrician with this affliction. While we were considering the time-honored ways of following up this disease process, our patient provided us with a most practical concept. At the disease onset, while chewing his tobacco, he was able to spit the juice only out the contralateral side at a 90° angle to the sagittal plane. As his strength slowly returned, his buccinator tone and aim improved. Over the weeks he was able to transcribe an arc that gradually progressed to the midline, at which time complete healing was obvious. The advantage in this method to the pain and cost
Diabetes and carbohydrates: the copper connection
Authors: G. Hill
Journal: JAMA (1987)

To the Editor.—  Bantle et al 1 show in a crossover study that after eight days on diets providing approximately 35% of energy as starch plus an additional 20% as fructose, sucrose, or starch, diabetics had lower plasma glucose levels when fructose was the added carbohydrate. Their work suggests that the source of dietary carbohydrates may affect glucose metabolism following food consumption. Interestingly, the animal literature has recently added copper as a new dimension to the carbohydrate/diabetes interaction. Reiser et al 2 have demonstrated that copper-deficient rats have significantly higher blood glucose levels after an oral glucose load compared with copper-supplemented rats. Adipocytes from copper-deficient rats bound less insulin than did cells from copper-fed rats, regardless of the carbohydrate source. 3   While copper deficiency may induce glucose intolerance, fructose feeding may induce clinical copper deficiency. Human subjects fed fructose as 20% of their diet developed biochemical evidence of decreased copper
In vivo measurement of thromboxane B2 and 6-keto-prostaglandin F1 alpha in humans in response to a standardized vascular injury and the influence of aspirin.
Authors: J M Gerrard, S Taback, S Singhroy, J C Docherty, I Kostolansky, A McNicol, N L Kobrinsky, J K McKenzie, R Rowe
Journal: Circulation (1989)

The effects of smoking, aspirin ingestion, and sex differences on bleeding times and bleeding time thromboxane B2 and 6-keto-prostaglandin (PG)F1 alpha production were examined. Nonsmoking men produced more thromboxane B2 (3.99 +/- 0.76 ng/ml) than nonsmoking women (2.13 +/- 0.24 ng/ml). Female smokers produced more thromboxane B2 (5.01 +/- 0.97 ng/ml) than nonsmoking women. Twenty-four hours after a single dose of 600 mg aspirin, in vitro production of thromboxane B2 in response to collagen fell by 95%, whereas in vivo production of thromboxane B2 and 6-keto-PGF1 alpha in bleeding time blood fell by 87% and 66%, respectively. Subjects with the lowest absolute levels of thromboxane B2 24 hours after aspirin were also those with the longest postaspirin bleeding times. Recovery of 6-keto-PGF1 alpha production was faster than recovery of thromboxane B2 production, but 6-keto-PGF1 alpha production for most subjects was still below basal 72 hours after aspirin. The influence of two different doses of long-term aspirin (80 mg every other day and 325 mg daily) on the in vivo production of thromboxane B2 and 6-keto-PGF1 alpha was studied in normals and diabetics. After 14 days of 80 mg aspirin every other day, thromboxane B2 and 6-keto-PGF1 alpha production were both substantially inhibited (93% and 78%, respectively). After 14 days of 325 mg aspirin daily, thromboxane B2 production was similarly substantially inhibited (93%), whereas 6-keto-PGF1 alpha was significantly less affected (only 45% inhibition). Study of a second group of five normal subjects confirmed that 6-keto-PGF1 alpha production was significantly inhibited 24 hours after the first dose of 325 mg aspirin but was not significantly less than basal after 14 days of 325 mg aspirin. The results suggest that 325 mg aspirin daily is more antithrombotic compared with 80 mg every other day due to the superior preservation of prostacyclin production.
Reply to L.K. Mell et al
Authors: Karla V. Ballman, Murielle Mauer, Ulrich Wedding, Supriya G. Mohile, Hyman Muss, Martine Extermann, Andrea Luciani, Harvey Jay Cohen, Arti Hurria, Stuart M. Lichtman, Giuseppe Curigliano, Hans Wildiers
Journal: Journal of Clinical Oncology (2014)
Ventilation-Perfusion Lung Imaging in Nitrofurantoin-related Pulmonary Reaction
Authors: NORMAN K.K. LEE, JAMES D. SLAVIN, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1992)

A woman with a history of multiple drug allergies was admitted for cough and dyspnea. She had been taking nitrofurantoin for 10 days, was febrile, and had a rash on the trunk and extremities. A chest radiograph revealed right-sided pleural effusion and basal markings. Because of suspected nitrofurantoin-related pulmonary reaction, the medication was discontinued and the patient was started on an H2-blocker and intravenous corticosteroids. She improved clinically, and within 24 hours a radiograph revealed that her chest had largely cleared. Restricted distribution of radioxenon, seen initially on a ventilation lung scan, also reverted to near normal by the follow-up. The first perfusion lung scan showed multiple but nonspecific changes; this also came back to near normal. The nitrofurantoin-related pulmonary reaction should be considered in patients who present with pulmonary signs/symptoms while on the medication.
Characteristic Traumatic Skin Lesions in Drug-Induced Coma
Authors: Stephen Mandy
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AFP-specific immunotherapy impairs growth of autochthonous hepatocellular carcinoma in mice
Authors: Jeannette Cany, Benoît Barteau, Lucile Tran, Vanessa Gauttier, Isabelle Archambeaud, Jean-Pierre Couty, Bruno Turlin, Bruno Pitard, Georges Vassaux, Nicolas Ferry, Sophie Conchon
Journal: Journal of Hepatology (2010)
All-trans retinoic acid (ATRA) in patients with chronic myeloid leukemia in the chronic phase
Authors: D Russo, M Regazzi, S Sacchi, G Visani, M Lazzarino, G Avvisati, PG Pelicci, G Dastoli, C Grandi, I Iacona, A Candoni, R Grattoni, P Galieni, S Rupoli, AM Liberati, AT Maiolo
Journal: Leukemia (1998)
Effect of nicotine chewing gum as an adjunct to general practitioner's advice against smoking.
Authors: M A Russell, R Merriman, J Stapleton, W Taylor
Journal: BMJ (1983)

This study was designed to see whether the offer and prescription of nicotine chewing gum would enhance the efficacy of general practitioners9 advice to stop smoking. A sample of 1938 cigarette smokers who attended the surgeries of 34 general practitioners in six group practices were assigned by week of attendance (in a balanced design) to one of three groups: (a) non-intervention controls, (b) advice plus booklet, and (c) advice plus booklet plus the offer of nicotine gum. Follow up was done after four months and one year. The results show a clear advantage for those offered the nicotine gum (p less than 0.001). After correction for those who refused or failed chemical validation and those who switched from cigarettes to a pipe or cigars, the proportions who were abstinent at four months and still abstinent at one year were 3.9%, 4.1%, and 8.8% in the three groups, respectively. These percentages are based on all cigarette smokers who attended the surgeries including those who did not wish to stop and those in the gum group who did not try the gum (47%). The effect of the offer and prescription of gum was to motivate more smokers to try to stop, to increase the success rate among those who tried, and to reduce the relapse rate of those who stopped. The self selected subgroup of 8% who used more than one box of 105 pieces of gum achieved a success rate of 24%. It would be feasible and effective for general practitioners to include the offer of nicotine gum and brief instructions on its use as part of a minimal intervention routine with all cigarette smokers. A general practitioner who adopts such a routine with similar success could expect to achieve about 35-40 long term ex-smokers a year and so save the lives of about 10 of them. If replicated by all general practitioners throughout the country the yield of ex-smokers would be about one million a year.
Seasons of Survival: Reflections of a Physician with Cancer
Authors: Fitzhugh Mullan
Journal: New England Journal of Medicine (1985)

When I was given a diagnosis of cancer, my first thought was not, Will I die? but rather, How can I beat this? Like a youngster who flunks a big test, I immediately began to worry about what to do to pass the course. I was 32 years old at the time, a physician, a husband, a parent, and a son. I had been healthy, athletic, and free of pain, but with the diagnosis, I became formally sick. My mind and my hopes riveted immediately on the goal of cure. Cure. The word itself became magic for me, a . . .