tbuckley/cabot-search huggingface dataset:
Liver biopsy: Increased risks in patients with cancer
Authors: Harold O. Conn
Journal: Hepatology (1991)

Nine thousand two hundred twelve liver biopsies were performed according to a defined protocol, and data were prospectively recorded to identify risk factors for major bleeding. There were 10 fatal and 22 nonfatal hemorrhages (0.11% and 0.24%, respectively). By comparison with a control group that did not hemorrhage, malignancy, age, sex, and the number of passes were the only predictable risk factors. The risk of fatal hemorrhage in patients with malignancy is estimated to be 0.4%; for nonfatal hemorrhage, 0.57%. In patients undergoing liver biopsy for nonmalignant disease, the risks are 0.04% and 0.16%, respectively.
Variations in number of births and perinatal mortality by day of week.
Authors: M J Bull
Journal: BMJ (1979)

goods vehicles was more successful.It was followed by a marked decrease in deaths and injuries among occupants of goods vehicles-3700 fewer were killed in 1977 than in 1970.2In 1977 in magistrates courts in England and Wales 1-2 million persons were found guilty of motoring offences; of these 97°were fined.3Penalties for serious transgressions were too mild.In 82 480 driving licence offences, including driving while disqualified, a fine of £20 or less was imposed in 830oi, and £50 or less in 970°.In 7899 cases of dangerous driving the penalty was £50 or less in 51°', and £100 or less in 96o0.Fines must be increased if they are to remain a credible deterrent.Disqualification and penalties are ineffective in a small minority of habitual offenders, who often also have a past history of other criminal offences.These cases present a social as well as a legal problem.Adequate enforcement with suitable penalties can improve road behaviour, but the real answer is to persuade the public that traffic regulations are an essential ingredient of road safety.
Cables1 Complex Couples Survival Signaling to the Cell Death Machinery
Authors: Zhi Shi, Hae R. Park, Yuhong Du, Zijian Li, Kejun Cheng, Shi-Yong Sun, Zenggang Li, Haian Fu, Fadlo R. Khuri
Journal: Cancer Research (2014)

Cables1 is a candidate tumor suppressor that negatively regulates cell growth by inhibiting cyclin-dependent kinases. Cables1 expression is lost frequently in human cancer but little is known about its regulation. Here, we report that Cables1 levels are controlled by a phosphorylation and 14-3-3-dependent mechanism. Mutagenic analyses identified two residues, T44 and T150, that are specifically critical for 14-3-3 binding and that serve as substrates for phosphorylation by the cell survival kinase Akt, which by binding directly to Cables1 recruits 14-3-3 to the complex. In cells, Cables1 overexpression induced apoptosis and inhibited cell growth in part by stabilizing p21 and decreasing Cdk2 kinase activity. Ectopic expression of activated Akt (AKT1) prevented Cables1-induced apoptosis. Clinically, levels of phosphorylated Cables1 and phosphorylated Akt correlated with each other in human lung cancer specimens, consistent with pathophysiologic significance. Together, our results illuminated a dynamic regulatory system through which activated Akt and 14-3-3 work directly together to neutralize a potent tumor suppressor function of Cables1.
WT1 mutations are secondary events in AML, show varying frequencies and impact on prognosis between genetic subgroups
Authors: M-T Krauth, T Alpermann, U Bacher, C Eder, F Dicker, M Ulke, S Kuznia, N Nadarajah, W Kern, C Haferlach, T Haferlach, S Schnittger
Journal: Leukemia (2014)
Physical efficiency tests on Indian male "Kabaddi" inter-university players.
Authors: A. K. De, P. K. Dasgupta, B. K. Panda, A. K. Bhattacharya
Journal: British Journal of Sports Medicine (1982)

The participants of inter-university "Kabaddi" competition showed higher values of height, weight and surface area than average Indian population, indicating better attainment of growth in them. Further, the values of respiratory efficiency tests like, FEV1, MEFR and PEFR were also observed to be more in these players, probably due to training effect. The grip strength values were high in comparison to those of Indian football goalkeepers and hockey players.
A CASE OF APPARENTLY ACUTE SIMPLE FEBRILE ERYTHEMA: ASSOCIATED WITH THE OCCURRENCE OF TWO SUBSEQUENT CASES OF SMALL-POX
Authors: D. S. Davies
Journal: BMJ (1909)

On this date he looked quite well.He was a thin but wiry man, of a rather neurotic temperament.The pulse and temperature were normal.Notbing abnormal could be found in the chest or abdomen.The tongue was clean but of a rather brighter red than normal.The bowels were regular, the urine neutral, quite clear, and contained neither albumen nor sugar.wOn the previous day he had had pain and swelling in the right ankle.The joint now appeared quite natural, but over the right tibia there were a few small red spots not unlike erythema nodosum.There was a slight scattered macular rash over the -abdomen.With the exception of some labial herpes there were no sores of any description anywhere on the body.No sign of disease could be found in the ears, nose, or throat.He wore a ,plate of artificial teeth, but had some of his own, which were -carious in places, and round some of them the gums were 3retracted and spongy.He was thought to be suffering from rheumatism, and was ordered 15-grain doses of sodium salicylate every four hours.Two davs later he had a further attack which was quite as violent as its predecessors.
Predicting children's short-term exposure to pesticides: results of a questionnaire screening approach.
Authors: Ken Sexton, John L Adgate, Lynn E Eberly, C Andrew Clayton, Roy W Whitmore, Edo D Pellizzari, Paul J Lioy, James J Quackenboss
Journal: Environmental Health Perspectives (2002)

The ability of questionnaires to predict children's exposure to pesticides was examined as part of the Minnesota Children's Pesticide Exposure Study (MNCPES). The MNCPES focused on a probability sample of 102 children between the ages of 3 and 13 years living in either urban (Minneapolis and St. Paul, MN) or nonurban (Rice and Goodhue Counties in Minnesota) households. Samples were collected in a variety of relevant media (air, food, beverages, tap water, house dust, soil, urine), and chemical analyses emphasized three organophosphate insecticides (chlorpyrifos, diazinon, malathion) and a herbicide (atrazine). Results indicate that the residential pesticide-use questions and overall screening approach used in the MNCPES were ineffective for identifying and oversampling children/households with higher levels of individual target pesticides.
Recent Trends in Euthanasia and Other End-of-Life Practices in Belgium
Authors: Kenneth Chambaere, Robert Vander Stichele, Freddy Mortier, Joachim Cohen, Luc Deliens
Journal: New England Journal of Medicine (2015)

In surveys of physicians about patients who had died in Belgium, where euthanasia is legal, the rate of euthanasia increased between 2007 and 2013, from 1.9 to 4.6% of deaths. The increase resulted from a rise in both the number of requests for euthanasia and the proportion of requests granted.
Digitized video flucrescence microscopy studies on isolated perfused rat livers. Effect of ethinylestradiol (EE) on the uptake of fluorescein and its attenuation by S-adenosylmethionine (SAMe) and ursodeoxycholate (URSO)
Authors: H.-P. Buscher, R. Schmidt, F. Szalay, W. Gerok
Journal: Journal of Hepatology (1989)
Clinical Lecture on Uterine Lameness
Authors: G. Hewitt
Journal: BMJ (1868)

GENTLEMEN,-AS science advances, new terms and new expressions are frequently necessary, either to attract attention to certain important facts or doctrines, or to represent ideas which require embodiment and a more exact syminbolisation; and, if I now adopt a somewhat new term, and discuss with you what I propose to term "uterine lameness", it is with the belief that the adoption of the term will serve an useful purpose.The word "lameness", as ordinarily used, implies a crippling, or fee- bleness, or paralysis of one of the lower extremities; and, in a wider sense, to convey the idea of weakness, as when we speak of a "lame excuse", a "lame argument", etc.I now, however, propose to use the word in an ordinary sense."Uterine lameness" I define to be inter- ference with locomotion, difficulty or pain in standing or walking, in various degrees, due to an abnormal condition of the uterus.It is well known that inflammations of the abdominal viscera, in their acute stage, often render it physically impossible for the patient to walk at all; even passive motion of the legs gives the sufferer from peritonitis the acutest pain.In cystitis, in the acute stage of pelvic cellulitis, and in many other conditions, instances of which will readily occur to you, locomotion is difficult or extremely painful, and therefore, in one sense of the word, impossible; but not because the muscles of the legs are
The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: Implications for diagnosis and classification
Authors: Massimo Roncalli, Elena Roz, Guido Coggi, Maria Grazia Di Rocco, Paola Bossi, Ernesto Minola, Marcello Gambacorta, Mauro Borzio
Journal: Hepatology (1999)

We investigated the angiogenic phenotype of regenerative and dysplastic hepatocellular nodules to assess whether these lesions have distinct vascular profiles compared with the adjacent nonneoplastic or malignant liver. Forty-three liver nodules surgically removed from 18 patients were classified into regenerative and dysplastic categories. Serial sections of each nodule, adjacent cirrhotic liver (16 patients), and associated hepatocellular carcinoma (HCC) (6 patients), have been immunostained against CD31 and α-smooth muscle actin (αSMA) to detect capillary and muscular vessels. The study included 20 large regenerative nodules (LRNs), 13 low-grade dysplastic nodules (LGDNs), and 10 high-grade dysplastic nodules (HGDNs). The number of both capillary units and unpaired arteries was significantly increased in HGDNs and malignant lesions over LGDNs, regenerative, and cirrhotic nodules ( P &lt; .01), which showed an overlapping vascular profile. In addition, the number of capillary units, but not that of unpaired arteries, was significantly increased in HCC compared with HGDNs ( P &lt; .01). These results show that certain angiogenic features segregate HGDNs from other nonmalignant nodules such as LRNs and LGDNs. The former group of lesions is similar to HCC whereas the latter group is undistinguishable from the adjacent cirrhosis as far as their vascular profile is concerned. The adopted investigative approach does not support the morphological distinction between LRNs and LGDNs although it suggests that HGDNs are likely advanced precursors of HCC. An abnormal number of capillary units and/or unpaired arteries in a nonmalignant hepatocellular nodule can be diagnostically helpful to identify a precancerous lesion.
The Role of Lymphangiography
Authors: George Schwarz
Journal: JAMA (1964)

Prognosis of Hodgkin's disease is closely related to its initial anatomic staging. Since treatment in many institutions is determined by this staging, it is of great importance that the extent of involvement be determined as accurately as possible. Until recently, staging was purely clinical, being based on manual palpation of nodes of varying accessibility and on the demonstration of enlarged nodes on chest roentgenograms. Although palpation could often be most accurate in the evaluation of superficial lymph nodes, it was quite tenuous in those node areas not accessible to direct touch. Thus the retroperitoneal region, containing a large fraction of the entire lymphatic system, was often poorly or incompletely evaluated. Indirect methods of lymph-node demonstration prior to lymphongiography were often unreliable and subject to a wide range of interpretations. Opacification of the gastrointestinal tract has traditionally been used as an indirect method. Yet, node demonstration is anatomically restricted to those
Magnifying endoscopic findings of early duodenal adenocarcinoma in relation to the pathological findings
Authors: Y. Onozato, S. Kakizaki, H. Ishihara, N. Sohara, H. Iizuka, S. Okamura, M. Mori, T. Ogawa, H. Itoh
Journal: Endoscopy (2008)

Primary duodenal carcinoma is a rare entity, with an autopsy incidence reported to range from 0.02 % to 0.12 % [1] [2] [3]. We recently experienced a case of early duodenal adenocarcinoma, which we describe here. We report the magnifying endoscopic findings in relation to the histopathological findings.
Asthma in Jemez Pueblo schoolchildren.
Authors: D Clark, R Gollub, W F Green, N Harvey, S J Murphy, J M Samet
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Asthma, a major chronic health problem of children, has received little investigation in Native Americans. We conducted a survey of asthma in children of Jemez Pueblo, Jemez, New Mexico, in response to concerns of the community and health care providers about the frequency of asthma. In collaboration with Jemez Pueblo, we developed a standardized questionnaire and administered it to parents of 318 children aged 3 to 13 years. Parents reported that 12.3% had been diagnosed as having asthma or reactive airway disease by a physician or other health care practitioner. Asthma was reported as still active at the time of the interview for 55% of those subjects. The study showed that asthma was not uncommon among the Jemez Pueblo children and, in fact, was more common than in recent nationwide surveys.
Protease Inhibitors May Reverse AIDS Dementia
Authors: Andrew A. Skolnick
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prothrombin time in liver failure: Time, ratio, activity percentage, or international normalized ratio
Authors: A Robert
Journal: Hepatology (1996)

Prothrombin time (PT) is a universal indicator of liver disease severity. However, variability in thromboplastin reagents leads to large interlaboratory differences in PT results. The aim of this study was to determine whether the use of the international normalized ratio (INR) or other modes of expression might achieve PT standardization in patients with liver failure. PT was measured with seven thromboplastin reagents with different sensitivities in plasmas from 27 patients with miscellaneous chronic and acute liver failure and, as a control population, 29 patients on oral anticoagulation therapy. PT was expressed in seconds, ratio, activity percentage, and INR. In patients with liver failure, only activity percentage expression eliminated variability in PT results obtained with the seven thromboplastins while INR, seconds, and ratio values remained significantly different (P < .01). In patients on oral anticoagulant therapy, only INR normalized PT results. We conclude that, in patients with liver failure, INR fails to yield a PT expression independent of the thromboplastin used and only activity percentage expression may provide a common international scale of PT reporting.
Christmas party games
Authors: James Owen Drife
Journal: BMJ (2007)

Christmas will soon be upon us! Make sure your departmental party is one to remember with our medical updates to those traditional games.

Musical cars —Managers and consultants can play this one together. The managers begin by closing half the consultants’ car park for essential maintenance. On 13 December they paint “Disabled Driver Only” on one of the 12 remaining spaces. With carols playing intermittently on the Tannoy, they paint one more space each day until …
Congenital anomalies after treatment for infertility
Authors: Soo-Mi Park, Raj Mathur, Gordon C S Smith
Journal: BMJ (2006)

It is not easy to prevent bullying and harassment in the workplace.It requires people to moderate their behaviour so that they become positive role models and demands considerable changes in institutional culture.The negative impact that bullying and harassment have on the wellbeing of students and doctors, overall morale in the medical workforce, and recruitment and retention in the profession demand our continuing efforts to resolve these problems.
Large Global Effective Population Sizes in Paramecium
Authors: Margaret S. Snoke, Thomas U. Berendonk, Dana Barth, Michael Lynch
Journal: Molecular Biology and Evolution (2006)

The genetic effective population size (Ne) of a species is an important parameter for understanding evolutionary dynamics because it mediates the relative effects of selection. However, because most Ne estimates for unicellular organisms are derived either from taxa with poorly understood species boundaries or from host-restricted pathogens and most unicellular species have prominent phases of clonal propagation potentially subject to strong selective sweeps, the hypothesis that Ne is elevated in single-celled organisms remains controversial. Drawing from observations on well-defined species within the genus Paramecium, we report exceptionally high levels of silent-site polymorphism, which appear to be a reflection of large Ne.
A Tactic of Last Resort
Authors: Borys Surawicz
Journal: New England Journal of Medicine (1982)

One of the lessons learned in the early days of open-heart surgery was how easily a surgeon could inadvertently create a complete atrioventricular block by damaging the bundle of His. Painstaking precautions have since been designed in order to identify the site of the bundle and thus protect it. At the same time, progress in pacemaker technology has made it possible to correct the consequences of an accidental lesion of the bundle. A particularly effective device has been the recently developed sequential atrioventricular pacemaker, which (as the name implies) makes use of the impulse triggered by the P wave, for . . .
TCT-871 Leveraging Preparatory Balloon Aortic Valvuloplasty (BAV) During TAVI for Improved Valve Sizing – A simple way to reduce Paravalvular Aortic Regurgitation (PAR)?!
Authors: Polykarpos Christos Patsalis, Fadi Al-Rashid, Bjoern Plicht, Matthias Riebisch, Daniel Wendt, Matthias Thielmann, Heinz Jakob, Gerd Heusch, Raimund Erbel, Thomas Konorza, Philipp Kahlert
Journal: Journal of the American College of Cardiology (2012)
Transplantation and the Law: Progress toward Uniformity
Authors: Alfred M. Sadler, Blair L. Sadler, E. Blythe Stason
Journal: New England Journal of Medicine (1970)

Abstract New laws based on the Uniform Anatomical Gift Act had been enacted in 41 states as of February 9, 1970. Most of these states adopted the Uniform Act with little or no change. The few important amendments include raising the donor age from 18, modifying the "good-faith" standard of care and altering the provision dealing with separation of responsibility. Progress toward uniformity of legislation allows efforts to be directed to efficient implementation of the law. This includes donation mechanisms for both the individual and the next of kin. The establishment of regional (and eventually national) networks of organ and tissue sharing indicate that there will be increasing quantities of tissue crossing state lines. Although all states have statutes dealing with the transportation of dead human bodies, only three refer specifically to the transport of organs and tissue for use in medical science, and these are permissive.
Effect of coronary stenosis on myocardial blood flow during exercise in the chronically pressure-overloaded hypertrophied left ventricle.
Authors: R J Bache, L Wright, D D Laxson, X Z Dai
Journal: Circulation (1990)

This study was performed to determine if a coronary artery stenosis would result in more-severe perfusion abnormalities in hypertrophied compared with normal canine hearts during exercise. Studies were performed in eight normal control dogs and in seven adult dogs in which a 67% increase in left ventricular mass wa produced by banding the ascending aorta at 9 weeks of age. Myocardial blood flow was measured by the microsphere method during treadmill exercise in the presence of a coronary artery stenosis that decreased distal coronary perfusion pressure to 55 or 42 mm Hg. At a coronary pressure of 55 mm Hg, mean myocardial blood flow was decreased by 23 +/- 5% in normal control dogs but was decreased by 53 +/- 10% in dogs with left ventricular hypertrophy (LVH) (p less than 0.05, comparing normal vs. LVH dogs). Similarly, at a coronary pressure of 42 mm Hg, mean blood flow was decreased by 53 +/- 6% below control in normal dogs but was decreased by 76 +/- 5% below control values in dogs with LVH (p less than 0.01, comparing normal vs. LVH dogs). In both groups of dogs, the stenosis caused a gradient of hypoperfusion, worsening from epicardium to endocardium. However, for each level of stenosis, subendocardial blood flow and the ratio of subendocardial to subepicardial blood flow was less in LVH than in normal canine hearts. These findings demonstrate that the presence of LVH secondary to long-term pressure overload is associated with an increased vulnerability to myocardial hypoperfusion during exercise in the presence of a coronary artery stenosis.
Genetic Aspects of Hemoglobins and Red Cell Enzymes.
Authors: Arno G. Motulsky
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Genetic Aspects of Hemoglobins and Red Cell Enzymes.Arno G. Motulsky, M.D., F.A.C.P.Arno G. Motulsky, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-844_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical implications of mutations can best be demonstrated by the hemoglobinopathies and enzymopathies. Mutations affecting hemoglobins and enzymes can have three types of effect: molecular alterations causing disease, such as certain hemolytic anemias, polycythemias, and methemoglobinemia; molecular alterations, causing disease only in certain environments, such as drug sensitivities caused by hemoglobin and glucose-6-phosphate dehydrogenase (G6PD) variants; molecular alterations without clinical consequences. Over 100 hemoglobin mutations and over 80 G6PD variants are known. Many are rare; others are frequent in certain populations and owe their origin to a selective survival advantage in the past. The clinical and genetic biology of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Arno G. Motulsky, M.D., F.A.C.P.Affiliations: Seattle, Wash. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 844-844KeywordsClinical geneticsEnzymesGeneticsHemoglobinHemoglobinopathiesHemolytic anemiaMethemoglobinemiaMutationPolycythemiaPopulation statistics ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...