tbuckley/cabot-search huggingface dataset:
Abstract 2364: Long non-coding RNA HOTAIR is expressed in small cell lung cancer and relevant to cellular proliferation, invasiveness and clinical relapse - analyses based on tumor tissues and cell lines.
Authors: Hiroshi Ono, Eisaku Miyauchi, Noriko Motoi, Masaru Ushijima, Masaaki Matsuura, Sakae Okumura, Makoto Nishio, Tetsuro Hirose, Satoru Itou, Mutsunori Fujiwara, Naohiko Inase, Yuichi Ishikawa
Journal: Cancer Research (2013)

Abstract Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis, showing early relapse after initial fair response to chemotherapy. A long non-coding RNA, Hox transcript antisense intergenic RNA (HOTAIR) has been reported to be involved in breast and colon cancer metastasis. Here we revealed, using 35 surgical SCLC cases, that HOTAIR was expressed highly in pure, rather than combined, SCLC (p=0.012) and that a subset of SCLC with its higher expression tended to relapse earlier (p=0.086). Also, knock down of HOTAIR by siRNA transfection in an SCLC cell line, SBC-3, led to the reduced proliferation activity and invasiveness, due to changes of expression of cell adhesion-related genes. These findings suggest that the HOTAIR expression changes gene expression in relation to cell adhesion and subsequently alters proliferation activity and invasiveness of tumor cells, resulting in early relapse of SCLC. Our results imply that HOTAIR could be a prognostic biomarker and a therapeutic target of SCLC. Citation Format: Hiroshi Ono, Eisaku Miyauchi, Noriko Motoi, Masaru Ushijima, Masaaki Matsuura, Sakae Okumura, Makoto Nishio, Tetsuro Hirose, Satoru Itou, Mutsunori Fujiwara, Naohiko Inase, Yuichi Ishikawa. Long non-coding RNA HOTAIR is expressed in small cell lung cancer and relevant to cellular proliferation, invasiveness and clinical relapse - analyses based on tumor tissues and cell lines. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2364. doi:10.1158/1538-7445.AM2013-2364
THE SIGNIFICANCE OF ERYTHEMA NODOSUM*
Authors: J. ODERY SYMES
Journal: British Journal of Dermatology (1932)

Journal Article THE SIGNIFICANCE OF ERYTHEMA NODOSUM Get access J. ODERY SYMES, M.D. J. ODERY SYMES, M.D. Consultant Physician, Bristol General Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 44, Issue 4, 1 April 1932, Pages 181–187, https://doi.org/10.1111/j.1365-2133.1932.tb09590.x Published: 01 April 1932
Keeping Up with the Medical Literature
Authors: DANIEL REINHARTH
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 November 1986Keeping Up with the Medical LiteratureDANIEL REINHARTH, M.D.DANIEL REINHARTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-5-807_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I take strong exception to the approach on keeping up with the medical literature proposed by Haynes and colleagues (1, 2). They suggest focusing exclusively on articles directly relevant to one's practice. For those in a primary care practice, this suggestion is almost irrelevant, because the range of problems encountered is vast. Even topics apparently unrelated may be important: for example, a general internist may read a surgical article to understand better what patients must go through and thereby to know what to advise them. As for subspecialists, most practice much primary care, and even the rest...References1. HAYNES R, MCKIBBON K, FITZGERALD D, GUYATT G, WALKER C, and SACKETT D. How to keep up with the medical literature: I. Why try to keep up and how to get started. Ann Intern Med. 1986;105:149-53. LinkGoogle Scholar2. HAYNES R, MCKIBBON K, FITZGERALD D, GUYATT G, WALKER C, and SACKETT D. How to keep up with the medical literature: II. Deciding which journals to read regularly. Ann Intern Med. 1986;105:309-12. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL REINHARTH, M.D.Affiliations: EAB Plaza Uniondale, NY 11556 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1986Volume 105, Issue 5Page: 807-808KeywordsSub-specialty care ePublished: 1 December 2008 Issue Published: 1 November 1986 PDF downloadLoading ...
Cochlear Implants for Children with Severe-to-Profound Hearing Loss
Authors: Blake C. Papsin, Karen A. Gordon
Journal: New England Journal of Medicine (2007)

Profound bilateral sensorineural hearing loss is diagnosed in a 4-month-old baby girl, and a cochlear implant is recommended. Unlike hearing aids, which amplify sound, cochlear implants stimulate the cochlear nerve directly. The benefit of this form of therapy depends on the patient's age at implantation, but it also requires participation by the patient and family in therapy for speech and oral language development.
False-positive Benzodiazepine Urine Test Due to Oxaprozin-Reply
Authors: Harvey Raphan
Journal: JAMA (1995)

In Reply.  —We thank Dr Pulini for her interest in this issue. Laboratory test interferences have been reported by Jelic-Ivanovic et al 1 and in the complete prescribing information for several NSAIDs, including etodolac (Lodine, Wyeth-Ayerst Laboratories, Philadelphia, Pa), naproxen sodium (Anaprox, Naprosyn; Syntex Puerto Rico Inc), fenoprofen calcium (Nalfon, Eli Lilly and Co, Indianapolis, Ind), and tolmetin sodium (Tolectin, McNeil Pharmaceuticals, Raritan, NJ), and GD Searle & Co has received reports of alleged false-positive benzodiazepine test results from standard urine toxicology screens for drugs of abuse in patients taking oxaprozin. Based on our investigation into this matter, the prescribing information for oxaprozin was updated in November 1993 to reflect the new information. The 1994 Physicians' Desk Reference (PDR) had already gone to press at that time; current information appears in the 1995 PDR and in the PDR on CD-ROM. 2   Although oxaprozin is not chemically related to the benzodiazepines,
Does Capitation Affect the Health of the Chronically Mentally III?
Authors: Nicole Lurie, Ira S. Moscovice, Michael Finch, Jon B. Christianson, Michael K. Popkin
Journal: JAMA (1992)

To determine the effect on health outcomes of enrollment of chronically mentally ill Medicaid recipients in prepaid plans vs traditional fee-for-service Medicaid.A randomized controlled trial. Clients who were randomly assigned to prepaid care were then permitted to choose among four capitated health plans. Clients returned to fee-for-service care at the end of the demonstration.The Medicaid Demonstration Project in Hennepin County, Minnesota, the urban center of which is Minneapolis.Seven hundred thirty-nine Medicaid clients who were classified as having chronic mental illness on the basis of Medicaid claims. Clients were interviewed at baseline (time 1) and at two follow-up points. Data were available for 96% of participants at the end of the intervention (time 2). Average duration of follow-up was 11 months. A subset of 370 clients with schizophrenia was followed up 11 months after the return of the prepaid group to fee-for-service care (time 3).General health status, physical functioning, social functioning, and psychiatric symptoms, assessed using the Schedule of Affective Disorders and Schizophrenia-Change version, the Global Assessment Scale, and indicators of community function.No significant differences between prepaid and fee-for-service groups in general health or psychiatric symptoms from baseline to time 2. After regression adjustment, 12% fewer clients in the prepaid group reported being victimized (P less than .01). At the end of time 3, the regression-adjusted Global Assessment Scale scores had worsened by 7.6 points more in the prepaid group in comparison with the fee-for-service group (P less than .02).There was no consistent evidence of harmful effects of enrolling chronically mentally ill Medicaid clients in prepaid care, at least in the short run. The generalizability of these findings may be limited to plans that control utilization by methods similar to those used in this study setting. Longer-term outcome studies should be undertaken to clarify the strength of the findings.
The Restless Tide: The Persistent Challenge of the Microbial World
Authors: Mary Lou Clements
Journal: JAMA (1982)

<i>The Restless Tide</i>, a collection of delightful essays, provides an absorbing overview of the historical origins of and recent advances in microbiology and immunology. The book also addresses issues concerning the usefulness of biomedical research and the quality of medical education and medical care. These essays were adapted from public lectures that the author delivered during his first five years as director of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health. Written in an entertaining, narrative style, these 11 essays present a current and broad perspective on different aspects of medicine. Each recalls the origins of current achievements, traces their evolution, gives an up-to-date account of each field discussed, and comments on the future research strategies required for over-coming present obstacles. Topics covered include recent advances in the control of infectious diseases by treatment or immunizations; the chameleon nature of microbes—shifts in antigenic constitution
HTLV-I Polymyositis in a Patient Also Infected with the Human Immunodeficiency Virus
Authors: Clayton A. Wiley, Michael Nerenberg, Didier Cros, Maria C. Soto-Aguilar
Journal: New England Journal of Medicine (1989)

EPIDEMIOLOGIC studies of the seroprevalence of antibodies to human T-cell leukemia virus Type I (HTLV-I) have associated this viral infection with leukemia, a chronic myelopathy,1 2 3 4 5 and polymyositis.2 In Jamaica, where the seroprevalence of HTLV-I is high (ranging from 7 to 18 percent among persons 30 to 69 years old6), all seven patients with polymyositis were seropositive for HTLV-I. In the United States, where the prevalence of HTLV-I infection is less than 0.1 percent,7 1 of 49 patients with polymyositis was HTLV-I seropositive. Recently, another retrovirus, the human immunodeficiency virus (HIV), has also been associated with a progressive myopathy.8 9 10 11 12 13 All . . .
Lesional blistering following narrow-band (TL-01) UVB phototherapy for psoriasis: a report of four cases
Authors: S.A. George, J. Ferguson
Journal: British Journal of Dermatology (1992)

Journal Article Lesional blistering following narrow‐band (TL‐01) UVB phototherapy for psoriasis: a report of four cases Get access S.A. George, S.A. George Photobiology Unit, Ninewells Hospital, Dundee DD1 9SY, U.K. Search for other works by this author on: Oxford Academic Google Scholar J. Ferguson J. Ferguson Photobiology Unit, Ninewells Hospital, Dundee DD1 9SY, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 4, 1 October 1992, Pages 445–446, https://doi.org/10.1111/j.1365-2133.1992.tb00470.x Published: 01 October 1992
Abstract 2340: Preferential targeting of KRAS mutant or BRAF mutant tumors using MEK inhibitors with distinct mechanisms of action.
Authors: Georgia Hatzivassiliou, Jacob Haling, Huifen Chen, Kyung Song, Shiuh-Ming Luoh, Steve Price, Robert Heald, Mark Zak, Mark Merchant, Klaus Hoeflich, Lori Friedman, Shiva Malek, Marcia P. Belvin
Journal: Cancer Research (2013)

Abstract KRAS and BRAF mutant cancers represent an area of high unmet medical need in oncology. Multiple allosteric MEK inhibitors are being tested in clinical trials in BRAF mutant and KRAS mutant cancers, where to date they have demonstrated impressive single agent activity in BRAF mutant melanoma, but not in KRAS mutant disease. Active, phosphorylated MEK is elevated in BRAFV600E mutant melanoma tumor models compared to KRAS mutant tumor models, in line with evidence that MAPK pathway regulation differs depending on the upstream oncogenic lesion. However, the precise differences in MEK activation by mutant KRAS or BRAF and how to create MEK inhibitors to block that activation are not known. In this study we describe two clinical, allosteric MEK inhibitors, GDC-0973 and GDC-0623, that have complementary efficacy profiles, with one showing superior efficacy in BRAF mutant models and the other showing superior efficacy in KRAS mutant models. Using structural information and targeted mutagenesis, we demonstrate that although both inhibitors effectively block MEK kinase activity and downstream ERK activation, their unique binding modes result in differential effects on active versus inactive MEK and MEK interaction with RAF that translates into unique efficacy profiles in BRAFV600E versus KRAS mutant tumors. GDC-0973 has already shown promising efficacy as a single agent in BRAFV600E mutant melanoma, and both inhibitors are currently being tested in KRAS mutant tumors in the clinic. Our study highlights that subtle differences in the binding mode of kinase inhibitors can have a large impact on inhibitor/target interactions and efficacy through allosteric mechanisms. These differences may impact the therapeutic index of MEK inhibitors in either BRAF mutant or KRAS mutant cancers. Citation Format: Georgia Hatzivassiliou, Jacob Haling, Huifen Chen, Kyung Song, Shiuh-Ming Luoh, Steve Price, Robert Heald, Mark Zak, Mark Merchant, Klaus Hoeflich, Lori Friedman, Shiva Malek, Marcia P. Belvin. Preferential targeting of KRAS mutant or BRAF mutant tumors using MEK inhibitors with distinct mechanisms of action. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2340. doi:10.1158/1538-7445.AM2013-2340
Choriocarcinoma with Hyperthyroidism: Probable Identity of the Thyrotropin with Human Chorionic Gonadotropin
Authors: WILLIAM T. CAVE
Journal: Annals of Internal Medicine (1976)

A 15-year-old girl developed severe hyperthyroidism secondary to metastatic choriocarcinoma. Her serum contained high levels of human chorionic gonadotropin (HCG) by radioimmunoassay and had a thyroid-stimulating activity different from that of pituitary thyrotropin (TSH) or of long-acting thyroid stimulator (LATS) in the McKenzie mouse bio-assay. Gradient ultracentrifugation localized this thyroid stimulator to a narrow zone midway between markers of transferrin and ovalbumin. On gel filtration it emerged just before albumin as a single peak coinciding with the peak for HCG. Her HCG was identical to an authentic sample of HCG in position on gel filtration columns and on gel electrophoresis. These results suggest that the thyrotropin of choriocarcinoma is HCG.
`Individualizing' acute leukemia therapy
Authors: Terra Ziporyn
Journal: JAMA (1983)

Not long ago, treating acute leukemia meant using a "cookbook" approach: With no well defined prognostic factors, all patients were likely to receive a standard therapy of an anthracycline (such as daunorubicin) combined with vincristine sulfate, prednisone, and either cytarabine or asparaginase. Now some specific pretreatment "markers" that indicate prognosis allow physicians to tailor therapy to individual patients. "We don't want to give aggressive therapy to a patient with a good chance of response to conventional therapy," explained Kenneth B. McCredie, MB, BS, professor of medicine and deputy head of the Department of Developmental Therapeutics at the M.D. Anderson Hospital and Tumor Institute at the University of Texas System Cancer Center, Houston. "Our aim is to individualize therapy." At M.D. Anderson, McCredie and co-workers have already started achieving this aim. Using a number of pretreatment factors such as presence or absence of infection or level of serum creatinine, they can
Palliative drugs are not for shortening life
Authors: D. Oliver
Journal: BMJ (1997)

Editor—Clare Dyer's report about Annie Lindsell, who has motor neurone disease, suggests that she may still be trying to ensure that her life can be ended at her request when she feels that she cannot face any further distress.1 She wants her general practitioner to be lawfully able to give drugs to relieve her distress in the terminal stages of the illness, even if this could shorten her life.

Although patients with motor neurone disease are understandably worried about their future and the possibility of …
Synovial amyloid deposits and chronic haemodialysis
Authors: N. Cary
Journal: Annals of the Rheumatic Diseases (1986)

Synovial amyloid deposits and chronic haemodialysis SIR, In their recent paper Mufioz-Gomez et al' suggested that localised synovial amyloidosis might be peculiar to chronic renal failure treated with periodical haemodialysis, and they made the assumption that it was the cause of an arthropathy.In fact localised amyloid deposition in synovium and also in articular cartilage is a common aging phenomenon2 apparently associated with osteoarthrosis, and it is relevant that four of the seven patients studied were aged 50 years or more.This type of aging deposit was actually referred to in the preceding editorial as 'joint capsule and articular cartilage' deposition.]The nature and extent of synovial amyloid deposits described in the article did not appear to differ from those associated with aging, and I would suggest that the finding of such deposits may represent no more than an accelerated age change.It is of interest in this context that synovial and articular cartilage amyloid deposits in patients with the so called amyloid arthropathy syndrome of multiple myeloma and primary amyloidosis do not appear to differ qualitatively from aging deposits either.4Such patients may, however, show gross soft tissue amyloid deposition around joints.The finding of synovial amyloid deposits in chronic haemodialysis patients may be unrelated to any arthropathy present and should not prevent other causes for an arthropathy from being sought.
Biomarkers of response to therapy in oesophago-gastric cancer
Authors: K R Fareed, P Kaye, I N Soomro, M Ilyas, S Martin, S L Parsons, S Madhusudan
Journal: Gut (2008)

Cancer of the oesophagus, gastro-oesophageal junction (GOJ) and stomach remains a major health problem worldwide. The evidence base for the optimal management of patients with operable oesophago-gastric cancer is evolving. Accepted approaches include preoperative chemotherapy followed by surgery (oesophageal cancer), chemo-radiotherapy alone (oesophageal cancer) and perioperative chemotherapy (gastric and gastro-oesophageal adenocarcinomas). The underlying principles behind neoadjuvant therapy are to improve resectability of the tumour by tumour shrinkage/downstaging and to treat occult metastatic disease as early as possible. The response rate to cytotoxic therapy is about 40% in oesophago-gastric cancer. Available evidence suggests that a favourable histopathological response to cytotoxic therapy may be a useful positive predictive marker in oesophago-gastric cancer. However, the ability to predict tumour response in routine clinical practice is difficult and is an area of intense investigation. There is evolving evidence for the role of predictive biomarkers in cancer in general and oesophago-gastric cancer in particular. We provide an overview on the current status of radiological and biological predictive biomarkers. We have focussed on clinical translational investigations and, where appropriate, provided pre-clinical insights. Whether predictive markers will be routinely incorporated in clinical practice remains to be seen as biomarker research is expensive and the data generated from these investigations are complex. It is clear that a concerted international effort between academia and industry is critical if personalised medicine as a practical reality for our cancer patients is to be realised.
Articular and Cutaneous Sporotrichosis
Authors: James W. Manhart
Journal: JAMA (1970)

A patient with chronic granulocytopenia and marrow hypoplasia of unknown etiology developed articular and cutaneous sporotrichosis while receiving corticosteroid therapy. The patient's active participation in gardening is presumably the major factor in the development of this mycotic infection. We postulate that the chronic granulocytopenia and corticosteroid administration contributed to the dissemination of the disease and the resulting articular involvement.
Whither Medical Education?
Authors: Emily Friedman
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unusual Complications of Regional Enteritis
Authors: Hilary Zarnow
Journal: JAMA (1976)

REGIONAL enteritis is associated with many complications; these include abdominal abscesses, hemorrhage, fistula formation, bowel obstruction, and malabsorption syndrome. Involvement of the duodenum is an unusual but well-established manifestation. Duodenobiliary communication, however, has been reported in only three cases,<sup>1</sup>and liver abscess is rare.<sup>2,3</sup>The following report describes a case of regional enteritis that was complicated by both a duodenobiliary fistula and a hepatic abscess. <h3>Report of a Case</h3> A 42-year-old man was admitted to Michael Reese Hospital and Medical Center with a 14-year history of regional enteritis. In 1960, he had undergone resection of the terminal ileum and ascending colon at another hospital. In April 1969, he had had a laparotomy for a right-lower-quadrant abscess, and a jejunotransverse colostomy was performed, leaving approximately 2 meters of functioning small bowel. The patient's status worsened progressively during the next two years, with recurrent attacks of cramping pain and fever.