tbuckley/cabot-search huggingface dataset:
Cardiac Three-Dimensional Magnetic Resonance Imaging and Fluoroscopy Merging
Authors: Joris Ector, Stijn De Buck, Jef Adams, Steven Dymarkowski, Jan Bogaert, Frederik Maes, Hein Heidbüchel
Journal: Circulation (2005)

Background— Modern nonfluoroscopic mapping systems construct 3D electroanatomic maps by tracking intracardiac catheters. They require specialized catheters and/or dedicated hardware. We developed a new method for electroanatomic mapping by merging detailed 3D models of the endocardial cavities with fluoroscopic images without the need for specialized hardware. This developmental work focused on the right atrium because of the difficulties in visualizing its anatomic landmarks in 3D with current approaches. Methods and Results— Cardiac MRI images were acquired in 39 patients referred for radiofrequency catheter ablation using balanced steady state free-precession sequences. We optimized acquisition and developed software for construction of detailed 3D models, after contouring of endocardial cavities with cross-checking of different imaging planes. 3D models were then merged with biplane fluoroscopic images by methods for image calibration and registration implemented in a custom software application. The feasibility and accuracy of this merging process were determined in heart-cast experiments and electroanatomic mapping in patients. Right atrial dimensions and relevant anatomic landmarks could be identified and measured in all 3D models. Cephalocaudal, posteroanterior, and lateroseptal diameters were, respectively, 65±11, 54±11, and 57±9 mm; posterior isthmus length was 26±6 mm; Eustachian valve height was 5±5 mm; and coronary sinus ostium height and width were 16±3 and 12±3 mm, respectively (n=39). The average alignment error was 0.2±0.3 mm in heart casts (n=40) and 1.9 to 2.5 mm in patient experiments (n=9), ie, acceptable for clinical use. In 11 patients, reliable catheter positioning and projection of activation times resulted in 3D electroanatomic maps with an unprecedented level of anatomic detail, which assisted ablation. Conclusions— This new approach allows activation visualization in a highly detailed 3D anatomic environment without the need for a specialized nonfluoroscopic mapping system.
National Study of Internal Medicine Manpower: XIX. Trends in Internal Medicine Residency Training Programs
Authors: Ronald M. Andersen, Christopher S. Lyttle, Claire H. Kohrman, Gerald S. Levey, Mary Margaret Clements
Journal: Annals of Internal Medicine (1992)

The National Study of Internal Medicine Manpower (NaSIMM) reports on the results of its 1989-1990 census of residency programs. The results are integrated into an organizational model identifying inputs, process, outputs, and environment of medical training programs. The number of residents entering internal medicine continues to grow at a relatively rapid pace. This growth is largely accounted for by foreign citizens who are graduates of foreign medical schools (AFMGs). Residents are spending an increasing proportion of their time in ambulatory care settings, but, thus far, this ambulatory care training has occurred primarily in hospital clinics and emergency rooms. The proportion of a program's residents entering general internal medicine was found in a multiple regression analysis to be negatively associated with the number of subspecialty programs located in the training hospital, the percent of AFMG residents in the program, and the presence of a preliminary track in the program.
Compartmentalizing Sentinel Lymph Nodes and Nonsentinel Lymph Nodes in Regional Lymph Nodes Draining the Primary Melanoma
Authors: Stanley P. L. Leong
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
The First Endoscopic Laser Coagulation in the Human Gl-Tract
Authors: P. Frühmorgen, F. Bodem, H. Reidenbach, B. Kaduk, L. Demling, H. Brand
Journal: Endoscopy (1975)

Preliminary report on the first endoscopic laser coagulations in the human gastrointestinal tract. The successful light coagulations were carried out on non-bleeding colonic haemangiomas and on a bleeding gastric ulcer. For the first time, a plastic light-guide that could be passed through the instrument channel of an endoscope, served as transmission system.
Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury
Authors: Kiyohiko Hotta, Masayuki Sho, Ichiro Yamato, Keiji Shimada, Hiroshi Harada, Takahiro Akahori, Shinji Nakamura, Noboru Konishi, Hideo Yagita, Katsuya Nonomura, Yoshiyuki Nakajima
Journal: Kidney International (2010)
Postponing or Preventing Deaths? Trends in Infant Survival-Reply
Authors: James W. Buehler
Journal: JAMA (1985)

In Reply.—  Dr Sepkowitz seems to have misinterpreted our study. We did not conclude that greater utilization of newborn intensive care was the single cause of the decline in neonatal mortality in Georgia. His assessment of the birth-weight distribution of deaths is incorrect and fails to take into account trends in the birth-weight distribution of births and birth-weight-specific mortality rates. 1 If this is done, approximately 90% of the reduction in neonatal and infant mortality from 1974-1975 to 1980-1981 can be attributed to lower birth-weight-specific mortality rates, and more than half of this improvement is due to better survival of infants with birth weights of less than 2,500 g.  The main goal of our study was to determine whether advances in neonatal survival have led to postponement rather than prevention of some infant deaths, and our findings suggested that this has occurred, but to a relatively small extent. To put
The Value of Lung Perfused Blood Volume Computed Tomography in Selecting the Target Lesions for the Effective Treatment of Chronic Thromboembolic Pulmonary Hypertension
Authors: Hiroto Shimokawahara, Shun Ijuuin, Koichiro Sonoda, Eikou Sai, Erika Yamashita, Kazuyuki Tanoue, Kiyohisa Hiramine, Kensaku Higashi, Hideki Tanaka, Norihito Nuruki, Masahiro Sonoda
Journal: Circulation (2014)
Confidential HIV Testing and Condom Promotion in Africa
Authors: Susan Allen
Journal: JAMA (1992)

We evaluated the impact of human immunodeficiency virus (HIV) testing and counseling on self-reported condom and spermicide use and on corresponding HIV seroconversion and gonorrhea rates in urban Rwandan women.Prospective cohort study with 2 years of follow-up, comparison of outcome variables before and after an intervention, and condom use measured in a control group that did not receive the intervention.Outpatient research clinic in Kigali, the capital of Rwanda.One thousand four hundred fifty-eight childbearing women, 32% of whom were infected with HIV, were enrolled in a prospective study in 1988, and followed at 3- to 6-month intervals for 2 years. Follow-up was available for 95% of subjects at year 1 and 92% at year 2.An acquired immunodeficiency syndrome (AIDS) educational videotape, HIV testing and counseling, and free condoms and spermicide were provided to all participants and interested sexual partners.Self-report of compliance with condom-spermicide use and observed incidence of HIV and gonorrhea.Only 7% of women reported ever trying condoms before the intervention, but 22% reported condom use with good compliance 1 year later. Women who were HIV-positive were more likely to adopt condom use than HIV-negative women (36% vs 16%; P < .05). Independent predictors of condom use, both in HIV-positive and in HIV-negative women, included HIV testing and counseling of the male partner, having a nonmonogamous relationship, and believing condoms were not dangerous. Human immunodeficiency virus seroconversion rates decreased significantly (from 4.1 to 1.8 per 100 person-years; P < .04) in women whose partners were tested and counseled. The prevalence of gonorrhea decreased substantially (13% to 6%; P < .05) among HIV-positive women, with the greatest reduction among condom users (16% to 4%; P < .05).A confidential HIV testing and counseling program was associated with increased use of condoms and reduced rates of gonorrhea and HIV in urban Rwandan women. The lack of risk reduction in HIV-negative women whose partner's serostatus was unknown was of concern. Interventions that promote HIV testing and counseling for both members of a couple should be considered in other high-prevalence areas.
A starch-based microparticulate system dedicated to diagnostic and therapeutic nuclear medicine applications
Authors: F. Lacoeuille, F. Hindré, M.C. Venier-Julienne, M. Sergent, F. Bouchet, S. Jouaneton, B. Denizot, S. Askienazy, J.P. Benoit, O.F. Couturier, J.J. Le Jeune
Journal: Biomaterials (2011)
Beethoven's Deafness
Authors: Joseph W. Miller
Journal: JAMA (1970)

To the Editor.—  After reading the thorough article on Beethoven's deafness which covered it from every angle and point of view and eliminated most of the diseases and afflictions which might have been the cause of his deafness, nevertheless I feel that one important cause has not been considered.  Young Beethoven had a very unhappy childhood. His father Johann, a singer in the Electoral Chapel at Bonn, was a chronic drunkard who earned little, drank a lot, and made his home sordid with drunken brawls. Yet, when the child Ludwig began to show an interest in music, his father was fired with ambition. He knew that Mozart as a child prodigy had brought in a great deal of money, so why not Ludwig? He enlisted his friend Tobias Pfeiffer to teach the boy piano. Without pity the greedy drink-crazed father forced the boy to play hour after hour. At times
Abstract LB-230: Automating sample preparation for single-cell protein phosphorylation analysis by flow cytometry
Authors: Li Liu, Kelechi Eluwa, Patricia Grom, Amy Yoder, Michael Kowalski, Yong Song, T. Vincent Shankey
Journal: Cancer Research (2010)

Abstract Protein phosphorylation plays essential roles in regulating cellproliferation, differentiation and other cellular processes. Aberrant regulation of protein kinases, can drive malignancy through inappropriate cell growth and survival signals. Understanding the phosphorylation status of specific cellular proteins in cancer has proven valuable in developing targeted therapies and assays to identify specific drug responses in individual cancer patients. The ability to analyze cells at the single cell level allows flow cytometry to measure protein phosphorylation in rare subsets of cells in complex populations such as blood or bone marrow specimens. However, sample preparation for protein phosphorylation analysis by flow cytometry can be technically challenging, time-consuming, and subject to error when performed manually. Furthermore, the procedure demands strict control of experimental conditions such as time and temperature due to the dynamic nature of protein phosphorylation. In this report, we describe an automated sample preparation method using a @Biomek® NXP Span-8 work-station to monitor the phosphorylation status of ERK and p38 MAPK in human peripheral blood monocytes. The method allows automation of sample preparation steps, including 1) ERK/p38 MAPK stimulation, 2) fixation, 3) erythrocyte lysis, 4) cell permeabilization, and, 5) staining with phospho-specific and cell surface marker antibodies. Using this approach, we were able to observe p38 MAPK and ERK activation in CD14+ monocytes following lipopolysaccharide (LPS) or phorbol-12-myristate-13 acetate (PMA) treatment. The automated sample preparation workstation is capable of processing 48 samples in approximately 2.5 hours. Note: *Method cited Not for Clinical purposes. @For Laboratory Use Only; not for use in diagnostic procedures. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-230.
An uncleavable form of pro–scatter factor suppresses tumor growth and dissemination in mice
Authors: Massimiliano Mazzone, Cristina Basilico, Silvia Cavassa, Selma Pennacchietti, Mauro Risio, Luigi Naldini, Paolo M. Comoglio, Paolo Michieli
Journal: Journal of Clinical Investigation (2004)

Scatter factor (SF), also known as hepatocyte growth factor, is ubiquitously present in the extracellular matrix of tissues in the form of an inactive precursor (pro-SF). In order to acquire biological activity, pro-SF must be cleaved by specific proteases present on the cell surface. The mature form of SF controls invasive cues in both physiological and pathological processes through activation of its receptor, the Met tyrosine kinase. By substituting a single amino acid in the proteolytic site, we engineered an unprocessable form of pro-SF (uncleavable SF). Using lentivirus vector technology, we achieved local or systemic delivery of uncleavable SF in mice. We provide evidence that (a) uncleavable SF inhibits both protease-mediated pro-SF conversion and active SF-induced Met activation; (b) local expression of uncleavable SF in tumors suppresses tumor growth, impairs tumor angiogenesis, and prevents metastatic dissemination; and (c) systemic expression of uncleavable SF dramatically inhibits the growth of transplanted tumors and abolishes the formation of spontaneous metastases without perturbing vital physiological functions. These data show that proteolytic activation of pro-SF is a limiting step in tumor progression, thus suggesting a new strategy for the treatment or prevention of the malignant conversion of neoplastic lesions.
Safety and costs of initiating angiotensin converting enzyme inhibitors for heart failure in primary care: analysis of individual patient data from studies of left ventricular dysfunction
Authors: J. Mason
Journal: BMJ (2000)

<h3>Abstract</h3> <b>Objective:</b> To estimate the costs and consequences of diagnosing symptomatic heart failure with left ventricular systolic dysfunction and initiating angiotensin converting enzyme inhibitors in primary care. <b>Design:</b> Analysis of individual patient data from studies of left ventricular dysfunction (SOLVD) to identify complications during test dose and titration phases. <b>Setting:</b> Two randomised controlled trials in secondary care. <b>Participants:</b> 7487 patients taking a test dose of enalapril at enrolment to the treatment and prevention trials; 2569 patients with clinical signs of heart failure and established left ventricular dysfunction entered the treatment trial. <b>Main outcome measures:</b> Discontinuation during the test dose period. Discontinuation or reduction of dose during the first year of treatment for heart failure. Costs of diagnosis and titration of treatment. <b>Results:</b> During the test dose phase, 585 patients (7.8%) reported side effects; 136 (1.8%) of these discontinued because of severe side effects. During the titration phase, compared with placebo, enalapril was associated with an increased risk of dose reduction due to hypotension (odds ratio 2.09, 95% confidence interval 1.15 to 3.82). However, overall, there was no difference in the rates of side effects leading to dose reduction or withdrawal between the enalapril and placebo groups. The costs of diagnosing heart failure with left ventricular systolic dysfunction and initiating and titrating an angiotensin converting enzyme inhibitor in primary care are £300 to £400. <b>Conclusions:</b> Treatment with angiotensin converting enzyme inhibitors can be safely started for patients with heart failure and left ventricular systolic dysfunction in primary care.
Precursors to Malignant Melanoma: Congenital and Dysplastic Nevi
Authors: Kenneth A. Arndt
Journal: JAMA (1984)

It has become evident during the past few years that there are two types of nevi that are predisposed to develop cutaneous melanoma. The incidence of malignant melanoma has been rising over the past decade. It is now clear that conservative excision is curative for virtually all thin tumors. Precursor lesions—congenital and dysplastic nevi—and most melanomas can be detected by careful inspection of the skin. Identification and appropriate treatment of such atypical melanocytic lesions are tantamount to saving a patient's life, for aside from surgery, no other effective therapy exists. The physical examination of<i>all</i>patients should include evaluation of their entire cutaneous surface for unusual pigmented areas. Evaluation for melanoma or precursors will often include biopsy or excision or, if the lesion is to be reassessed periodically, a photograph to document its appearance. The Figures presented here and the accompanying National Institutes of Health consensus statement will guide clinicians
Responsible behavioral science generalizations and applications require much more than non-WEIRD samples
Authors: Vladimir J. Konečni
Journal: Behavioral and Brain Sciences (2010)

There are many methodological considerations - some intricately associated with the use of WEIRD samples - that adversely affect external validity as much as, or even more than, unrepresentative sampling does. Among suspect applications, especially worrisome is the incorporation of WEIRD-based findings regarding moral reasoning and retribution into normative expectations, such as might be held by international criminal tribunals in "cognitively distant" war-torn areas.
Nephrogenic Hypertension (Goldblatt Kidney) Following Operative Trauma to the Renal Artery
Authors: RICHARD T. MCDONALD, D. EMERICK SZILAGYI, ROGER F. SMITH
Journal: Circulation (1958)

The thrombosis of the right renal artery following operative injury set off a chain of events closely duplicating the arterial hypertension observed by Goldblatt after constriction or occlusion of the renal arteries in experimental animals. The resulting hypertension was severe, fulminating, prolonged, and resistant to treatment by hypotensive and ganglion-blocking agents; it was associated with pulmonary edema, myocardial infarction, and impairment of the renal function. Nephrectomy brought about a return of the blood pressure to normal levels. The concentration of renin in the removed kidney was 34 times greater than normal.
Molecular Genetic Studies of Tumor suppressor Gene Regions on chromosomes 13 and 17 in Colorectal Tumors
Authors: R. A. Lothe, T. Fossli, H. E. Danielsen, A. E. Stenwig, J. M. Nesland, B. Gallie, A.-L. Borressen
Journal: JNCI Journal of the National Cancer Institute (1992)

Background: In the majority of colorectal carcinomas, both copies of the tumor suppressor gene TP53 (tumor protein 53) are known to be inactivated. In contrast to a loss of tumor suppressor function, it has been suggested that an increased copy number of the RBI gene is involved in the progression of these tumors. Purpose: To determine genetic alterations at chromosomes 13 and 17 in colorectal tumors, we have studied several loci on these chromosomes, with special focus on the RBI and TP53 genes at both the level of DNA sequence and the level of gene expression. Methods: Restriction fragment length polymorphism analysis was performed after alkaline Southern blotting of the DNA fragments and hybridization (in 7% sodium dodecyl sulfate and 0.5 M NaPO 4 of the nylon membranes with multi-primed, radioactively labeled probes. Total RNA was extracted from tissue biopsy specimens by homogenization of the samples in guanidinium thiocyanate followed by separation in a CsCl gradient. By use of an image-processing system, x-ray film signals were measured densitometrically. Point mutations within the TP53 gene were detected by use of polymerase chain reaction (PCR) in combination with constant denaturant gel electrophoresis. Direct sequencing of PCR products revealed the exact nature of the mutations. Protein expression of TP53 was seen by immuno-staining of sections from paraffin-embedded material using a mouse monoclonal antibody. The two-sided Fisher‘s Exact Test was used for statistical analysis. Results: An increase in allelic copy number at 13q loci was seen in 10 (32% of 31 tumors. In the majority of the cases, this increase probably reflected a change in the diploid status of chromosome 13; in some cases, however, only part of the 13q seemed to be involved. The RBI gene showed an elevated level of RNA compared with the β-actin signal. Four-teen (48%) of 29 tumors showed loss of heterozygosity at loci on 17p, and base mutations within the TP53 gene were seen in 14 (42% of 33 tumors. RNA and protein analyses of TP53 revealed an increased level of expression in the tumors compared with normal mucosa. Allelic variations seen at 13q and 17p were not associated ( P = .7). Conclusions: Our results suggest that, in addition to aneuploidy, gain of specific chromosome 13 sequences is involved in the tumorigenesis of the colon and rectum. In addition, they confirm the importance of TP53 mutations for the progression of such tumors and support the view that accumulation of events is more important than the order of events. The genetic changes observed at chromosome arms 13q and 17p seem to be independent of each other. [J Natl Cancer Inst 84:1100–1108, 1992]
Managing tuberculosis and HIV infection: Author's reply
Authors: P. Ormerod
Journal: BMJ (1992)

the risk of an increase in tuberculosis related to HIV is small.2An audit of cases of tuberculosis (April 1990-March 1991) in Riverside Health Authority showed two problems with the current surveillance of HIV infection and tuberculosis based on notifi- cation data.Firstly, tuberculosis in HIV infected people is less likely to be notified than that in other people.In our study only four (40%) of 10 dual infections were notified; in contrast, 50 (74%) of 68 cases of tuberculosis in people not known to be infected with HIV were notified.Furthermore, HIV positive patients given antituberculous treat- ment without bacteriological evidence being sought were even less likely to be notified (one
Drug chiefs ponder how to improve industry's reputation
Authors: Bob Burton
Journal: BMJ (2005)

Drug industry executives and advisers told a conference in Sydney last week that the poor public standing of the industry was hindering its ability to sell its products at higher prices to government agencies as well as its attempts to address public criticism.

Introducing a panel discussion on reputation management, Kristin Austin, director of the public relations company Ruder Finn, said that a review of coverage of the industry in the Sydney print media showed 30 positive stories in the preceding year but 40 critical stories.

“Each negative story requires six …