tbuckley/cabot-search huggingface dataset:
Serotonin, Cushing’s Disease, and Depression
Authors: Nicoletta Sonino, Giovanni A. Fava
Journal: Psychotherapy and Psychosomatics (1996)

Editorials| February 18 2010 Serotonin, Cushing's Disease, and Depression Subject Area: Psychiatry and Psychology Nicoletta Sonino; Nicoletta Sonino aInstitute of Semeiotica Medica, University of Padova, Search for other works by this author on: This Site PubMed Google Scholar Giovanni A. Fava Giovanni A. Fava bDepartment of Psychology, University of Bologna, Italy Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1996) 65 (2): 63–65. https://doi.org/10.1159/000289048 Article history Published Online: February 18 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Nicoletta Sonino, Giovanni A. Fava; Serotonin, Cushing's Disease, and Depression. Psychother Psychosom 1 February 1996; 65 (2): 63–65. https://doi.org/10.1159/000289048 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1996Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Concurrent or sequential use of cytotoxic chemotherapy and hormone treatment in advanced breast cancer: report of the Swiss Group for Clinical Cancer Research.
Authors: F Cavalli, M Beer, G Martz, W F Jungi, P Alberto, J P Obrecht, B Mermillod, K W Brunner
Journal: BMJ (1983)

In a trial of combined hormone treatment and cytotoxic chemotherapy 464 patients with advanced breast cancer were randomly allocated to either concurrent or sequential treatment. Cytotoxic drugs were given only if the antitumour activity of the hormone treatment was inadequate. Hormone treatment consisted of oophorectomy for premenopausal and tamoxifen administration for postmenopausal patients. Length of survival was better, though not significantly, in premenopausal patients (p = 0.29) treated concurrently and in postmenopausal women (p = 0.17) treated sequentially; the difference was highly significant (p = 0.003) only for postmenopausal women in the low-risk category. The findings suggest that postmenopausal women with metastatic breast cancer should probably be treated primarily by carefully monitored hormone treatment.
Scintigraphic Demonstration of Hepatocellular Damage after Verapamil Toxicity
Authors: PURUSHOTHAM VELUVOLU, JOHN P. WHALEN, B. DAVID COLLIER, BURTON FRIEDMAN
Journal: Clinical Nuclear Medicine (1988)

Tc-99m pyrophosphate imaging was performed to rule out a myocardial infarction 1 day after verapamil therapy. An incidental finding was patchy liver uptake, suggesting hepatocellular damage.
IMMUNOLOGICAL EFFECTS OF THERMAL INJURY
Authors: Felix T. Rapaport, Angus Sampath, Kyiochi Kano, Robert T. McCluskey, Felix Milgrom
Journal: The Journal of Experimental Medicine (1969)

In the present study, controlled burns of 1 testis have induced the formation of testis-specific antibodies in Hartley guinea pigs. The antibodies reacted with autologous as well as homologous testicular extracts. In addition, pathological changes have been noted in the germinal components of the contralateral testis, which were similar to those observed after the induction of experimental allergic orchitis by active immunization with testicular tissue. Results of the study indicate that thermal injury to guinea pig testes can induce an autoimmune response similar to that observed after immunization with autologous or homologous testicular tissue. The antibodies formed were organ-and species-specific against a testicular antigen. Thermal injury may be associated with autoimmunization of the host by the injured organ.
Personal Care in Medicine of the Future
Authors: James A. Halsted
Journal: New England Journal of Medicine (1962)

THE diminishing prestige of the medical profession in the public eye is a matter that must concern practicing physicians, medical educators and administrators, as well as the leaders of organized medicine. Yet it is not enough to explain this (as is customary) on the grounds that more and more people feel convinced that physicians are more interested in money than in practicing a profession, unjustified as that criticism is for the vast majority of physicians. Some other factor in medical practice, unrelated to the economics of medicine, has been lost in the great increase in specialization. Perhaps this was best . . .
Percutaneous coronary intervention. I: History and development
Authors: E. D Grech
Journal: BMJ (2003)

The term “angina pectoris” was introduced by Heberden in 1772 to describe a syndrome characterised by a sensation of “strangling and anxiety” in the chest. Today, it is used for chest discomfort attributed to myocardial ischaemia arising from increased myocardial oxygen consumption. This is often induced by physical exertion, and the commonest aetiology is atheromatous coronary artery disease. The terms “chronic” and “stable” refer to anginal symptoms that have been present for at least several weeks without major deterioration. However, symptom variation occurs for several reasons, such as mental stress, ambient temperature, consumption of alcohol or large meals, and factors that may increase coronary tone such as drugs and hormonal change.

View this table:

Unequivocal indications for use of coronary stents



The Canadian Cardiovascular Society has provided a graded classification of angina which has become widely used. In clinical practice, it is important to describe accurately specific activities associated with angina in each patient. This should include walking distance, frequency, and duration of episodes.

In the management of chronic stable angina, there are two invasive techniques available for myocardial revascularisation: coronary artery bypass surgery and catheter attached devices. Although coronary artery bypass surgery was introduced in 1968, the first percutaneous transluminal coronary angioplasty was not performed until September 1977 by Andreas Gruentzig, a Swiss radiologist, in Zurich. The patient, 38 year old Adolph Bachman, underwent successful angioplasty to a left coronary artery lesion and remains well to this day. After the success of the operation, six patients were successfully treated with percutaneous transluminal coronary angioplasty in that year.

By today's standards, the early procedures used cumbersome equipment: guide catheters were large and could easily traumatise the vessel, there were no guidewires, and balloon catheters were large with low burst pressures. As a result, the procedure was limited to patients with refractory angina, good …
PTTG is a Secretory Protein in Human Pituitary Adenomas and in Mouse Pituitary Tumor Cell Lines
Authors: Takeo Minematsu, Noboru Egashira, Hanako Kajiya, Mao Takei, Susumu Takekoshi, Yoshiko Itoh, Hideo Tsukamoto, Johbu Itoh, Naoko Sanno, Akira Teramoto, Robert Yoshiyuki Osamura
Journal: Endocrine Pathology (2007)
GMC guidance puts duty on doctors to try to prevent child abuse
Authors: C. Dyer
Journal: BMJ (2011)

All doctors in the United Kingdom, not just those treating children, will have an explicit duty to consider the needs of children and, where possible, take action to prevent their abuse and neglect, under proposed new guidance from the General Medical Council.

Doctors caring for adult patients must consider whether a patient poses a risk to children or young people, says the draft guidance from an expert working group chaired by the Court of Appeal judge Lord Justice Thorpe. Every doctor should be able to spot signs at an early stage that a child might be at risk from, for example, a parent or carer who misuses alcohol or drugs.

The guidance says that doctors should tell the parents …
Mount Everest: a deadly playground
Authors: M. Rostrup
Journal: BMJ (1998)

On 11 May 1997 five climbers died during their descent from Mount Everest on the north ridge. Exactly one year and one day earlier eight people died during a storm below the summit. Seven more died later the same year, making 1996 the worst ever on Everest. As a doctor on a Norwegian Everest expedition, I partly witnessed and partly took part in rescue operations on the north side of the mountain where four climbers died. This was my sixth expedition to the Himalayas and my 12th to mountains above 5000 m. The incidents illustrate important medical and ethical aspects of high altitude climbing, and should be considered carefully by expedition doctors.

On 10 May 1996 three Indian climbers were overtaken by bad weather close to the summit and did not make it back to the camp that night. Early next morning five climbers from another expedition headed for the summit. They met the first Indian climber alive on the north ridge below the most difficult part of the climb—the second step. He was reported to be moving slowly downwards. Despite obvious need for help, the team continued and met his two fellow climbers above the second step, still alive, but suffering from altitude sickness, exhaustion, and hypothermia. They …
ENGLISH WEIGHTS AND MEASURES
Authors: Francis L. Burnett
Journal: JAMA (1926)

To the Editor:  —The comment on the use of the English weights and measures by Americans (The Journal, February 6) is timely and well taken. Foreign journals may well point out that physicians and scientific men would be even more appreciated abroad if the metric system were generally recognized in this country. But why comment when immediate and helpful action may be taken to bring about a universal standard? A bill (H. R. 10) has been introduced into the U. S. House of Representatives by Congressman Fred A. Britten of Illinois to extend the use of the metric weights and measures in merchandising after Jan. 1, 1935, and has recently been referred to the Committee on Coinage, Weights and Measures, of which Hon. Randolph Perkins of New Jersey is chairman. Letters written to the chairman and other members of the committee will undoubtedly aid in the passage of this bill.
Systemic MiRNA Levels as Novel Breast Cancer Biomarkers.
Authors: H. Heneghan, N. Miller, J. Newell, M. Kerin
Journal: Cancer Research (2009)

Abstract Background: The development of clinically validated biomarkers for breast cancer has remained an insurmountable task despite other advances in the field of molecular biology. Mi(cro)RNAs have many characteristics of an ideal biomarker most notably their inherent stability, resilience, and ease of detection. Recent blood based miRNA profiling studies, reporting their presence in serum and plasma, have generated the concept that circulating miRNAs hold much potential as novel non-invasive biomarkers for cancer and other disease processes. The objective of this study was to investigate the potential of circulating microRNAs as novel breast cancer biomarkers.Materials and Methods: Using a real-time quantitative PCR approach, expression levels of a panel of 7 oncogenic miRNAs were quantified in tissue and blood specimens of 148 patients with breast cancer and 24 age-matched disease free control individuals. Advanced QBase Plus software and SPSS were used for biostatistical analysis of the data, and correlation with clinicopathological variables.Results: Cancer specific miRNAs were detected and significantly altered in the circulation of breast cancer patients preoperatively, most notably miR-195 (12 fold increase) and let-7a (5-fold increase), (p &amp;lt; 0.001 and p&amp;lt;0.001 respectively). Increased systemic miR-195 levels in breast cancer patients were also reflected in breast tumors. Systemic let-7a levels varied inversely with disease stage, being highest in carcinoma in-situ patients and getting progressively lower through to stage IV invasive disease. Furthermore we identified that circulating levels of miR-195 and let-7a decreased in cancer patients post-operatively following curative tumor resection (p&amp;lt;0.001 and p&amp;lt;0.001 respectively). Finally we found that specific circulating miRNAs correlated with certain clinicopathological variables, namely nodal status and estrogen receptor statusDiscussion/Conclusion: Our results demonstrates the novel finding that miRNAs are detectable in the circulation of breast cancer patients, that expression profiles differ between patients and controls, and that the circulating miRNA expression profile correlates with various biopathologic parameters of breast cancer. Also, systemic miRNA levels revert to normal levels following tumour resection. In this, lies the expectation that systemic miRNAs will be clinically useful as a novel minimally invasive tool to aid in the early diagnosis and perioperative management of breast cancer. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 32.
Scientific Verdict Still Out on DHEA
Authors: Andrew A. Skolnick
Journal: JAMA (1996)

PERHAPS NO drug better illustrates the problem with the US Dietary Supplement Health and Education Act of 1994 than does the adrenal hormone dehydroepiandrosterone (DHEA). Although mounting evidence suggests that DHEA may have a broad range of clinical uses, the long-term effects of the substance are unknown. But that hasn't prevented the creation of a large and growing market for what many are calling a miraculous "Fountain of Youth." DHEA has become the latest drug of choice for talk shows and reports in the print and broadcast media, where it is being touted as an "antidote for aging" and a "superhormone" that can help burn fat, build muscle mass, boost libido, strengthen the immune system, prevent heart disease, cancer, and non—insulin-dependent diabetes, retard memory loss, help in the treatment of systemic lupus erythematosus, and prevent or slow the progression of Alzheimer and Parkinson diseases. All this, despite the
Normal Cholesterol Levels With Lovastatin (Mevinolin) Therapy in a Child With Homozygous Familial Hypercholesterolemia Following Liver Transplantation
Authors: Cara East, Scott M. Grundy, David W. Bilheimer
Journal: JAMA (1986)

Patients with homozygous familial hypercholesterolemia produce no normal low-density lipoprotein (LDL) receptors, and as a result, LDL accumulates in plasma, causing severe premature atherosclerosis. Two years ago, liver transplantation was performed in a child with homozygous familial hypercholesterolemia, restoring LDL receptor activity to about 60% of normal and reducing the LDL cholesterol level by 81%. However, the patient's lipoprotein levels remained significantly elevated for her age and sex. Treatment with lovastatin (mevinolin) one year after transplantation produced a marked improvement in the patient's lipoprotein profile. The total and LDL cholesterol levels fell 40% and 49%, respectively, to values within the normal range. The level of very low-density lipoprotein cholesterol fell 41%, and the level of total triglycerides declined 28%. While lovastatin therapy decreased the production rate of LDL by 35%, it did not affect the LDL fractional clearance rate. Thus, the combination of liver transplantation and lovastatin restored total and LDL cholesterol levels to normal in this patient with homozygous familial hypercholesterolemia.
CHANGES IN THE SKIN-VESSELS FROM PROTRACTED ACTION OE CLIMATIC FACTORS AND THEIR SIGNIFICANCE IN VARIOUS SKIN-DISEASES
Authors: H. HAXTHAUSEN, Axel Reyn
Journal: British Journal of Dermatology (1930)

Journal Article CHANGES IN THE SKIN‐VESSELS FROM PROTRACTED ACTION OE CLIMATIC FACTORS AND THEIR SIGNIFICANCE IN VARIOUS SKIN‐DISEASES Get access H. HAXTHAUSEN, M.D., H. HAXTHAUSEN, M.D. Skin Clinic of the Finsen Institute, Copenhagen Search for other works by this author on: Oxford Academic Google Scholar Axel Reyn Axel Reyn Skin Clinic of the Finsen Institute, Copenhagen Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 42, Issue 3, 1 March 1930, Pages 105–125, https://doi.org/10.1111/j.1365-2133.1930.tb09399.x Published: 01 March 1930
Efficacy of Peripheral Vascular Surgery
Authors: Solomon Fisch
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The article by Miller and Griepp, "A Modern View of the Surgical Treatment of Peripheral Arterial Disease" (240:1524, 1978), attempts to stimulate referrals for this form of therapy. The emphasis of the article is on the low operative morbidity and mortality and the rationality of the procedures, while elaborating on technical surgical details. These are important; however, there was a sparseness of discussion on proof of efficacy—the overriding consideration—by well-controlled and well-designed studies to support this therapeutic modality preferentially. Until that is done, the "communication gap" described by the authors may persist. This comment should probably exclude aortic aneurysms, since the dismal course of the untreated disease appears to be well documented.
The Role of Telomeres and Telomerase in Cancer Research
Authors: Sheila A. Stewart, Alison A. Bertuch
Journal: Cancer Research (2010)

The fourth AACR Special Conference on The Role of Telomeres and Telomerase in Cancer Research was held February 27 to March 2, 2010 in Fort Worth, TX. The meeting was organized to bring together those interested in the basic molecular mechanisms that govern telomere dynamics and stability with those interested in the clinical implications of telomere dysfunction and the use of telomeres and telomerase as therapeutic targets. The meeting was extremely successful as evidenced by the attendance and quality of the presentations. Indeed, several important themes emerged including (a) the intricate connection between the DNA replication and repair machineries in basic telomere replication and stability, (b) the complex interplay between the telomere-specific shelterin components and DNA repair proteins, (c) the nontelomeric functions of TERT in numerous cell types including stem cells, (d) a growing appreciation for the connection that exists between telomere maintenance deficiency states and diverse conditions such as idiopathic pulmonary fibrosis and hematopoietic malignancies, and (e) the successful progression of agents targeting telomerase directly and immunologically to phase III clinical trials. Evident at the meeting was the vibrant energy that permeates the telomere field and the important biological and medical findings that it continues to yield.
Acquisition of adaptive skills
Authors: Peter C Badgio, Gregory S Halperin, Jacques P Barber
Journal: Clinical Psychology Review (1999)

We argue that there are important areas of overlap in the types of patient change processes that occur in cognitive therapy and dynamic therapy. These common processes of patient change have been obscured by differences in language and theoretical constructs between the two traditions. We suggest that the acquisition of adaptive skills describes patient change processes that are common to both therapies. More specifically, we propose that the concept of adaptive skills encompasses both the compensatory skills model of cognitive therapy (Barber & DeRubeis, 1989) and some of the patient changes that occur in dynamic therapies. In clarifying these areas of overlap between cognitive and dynamic therapies encompassed by the adaptive skills acquired in both, the present article highlights the fact that the two therapeutic traditions employ radically different techniques to achieve some of the same outcomes. Recognizing the overlap between change processes in the two types of therapy, and adopting a common language for them, allows for further theoretical and empirical investigation of therapy process and outcome.
ON OCCIPITO-POSTERIOR PRESENTATIONS.
Authors: ISAAC E. TAYLOR
Journal: JAMA (1884)

Read before the Section on Obstetrics and Diseases of Women, American Medical Association, May 8, 1884. Mr. Chairman, and Gentlemen of the Section on Obstetrics and the Diseases of Women:—Requested by your honored and distinguished chairman to present a paper at this meeting on some subject appertaining o the branch of the profession we are all interested in, I thought that a few remarks on the management and rectification of the child's head in the occipito-posterior position in difficult cases might not prove to be unacceptable. I selected this subject in lieu of a paper on some gynæcological topic, having understood that there were several papers in that department to be offered for our edification. The subject I propose to consider is one which, at the present day, might appear to be almost superfluous and useless for any one to undertake, much less to offer anything different from that which
Innovation centre aims to contain US healthcare costs
Authors: B. Roehr
Journal: BMJ (2011)

The US is hoping to avoid continuously escalating healthcare costs by combining existing and new aspects of government programmes into a new bureaucratic structure called the Center for Medicare and Medicaid Innovation.

A packed briefing for congressional staffers on 18 July heard much about how the process might be implemented but there were no silver bullets to slay the fiscal beast.

The Innovation Center was created as part of healthcare reform legislation under the Affordable Care Act. Its goal is to identify, develop, assess, support, and spread new approaches to healthcare finance and delivery that can help improve quality and lower costs.

The $10bn (£6.2bn; $7bn) budget for the period 2011 to 2019 …
Effect of Time to Treatment on Treatment Response With C1 Esterase-Inhibitor Concentrate (Berinert®) for Acute Hereditary Angioedema Attacks
Authors: J.A. Bernstein, D.S. Hurewitz, A.K. Bewtra, T. Machnig, H. Keinecke, T.J. Craig
Journal: Journal of Allergy and Clinical Immunology (2012)