Aortic Valve Disease and Hemolytic Anemia
Authors: DAVID W. WESTRING
Journal: Annals of Internal Medicine (1966)

Article1 August 1966Aortic Valve Disease and Hemolytic AnemiaDAVID W. WESTRING, M.D.DAVID W. WESTRING, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-203 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe postoperative syndrome of anemia, hemoglobinemia, hemosiderinuria, and a characteristic poikilocytosis (schistocytes) has been observed since the widespread use of endocardial prostheses. Hematocrit volumes in operative subjects decreased after implacement of the Hufnagel ball valve (1), and the syndrome was subsequently produced in dogs with Hufnagel valves (2, 3). Since then, many reports of this complication have appeared, nearly all concerning aortic valve replacements or Teflon repairs of ostium primum defects. Hemolysis was discovered in many of these patients when convalescence was disrupted by avulsion of the valve prosthesis from its muscle attachment (4, 5) torn prosthetic valve cusps (6),...References1. ROSEHUFNAGELFREISHARVEYPARTENOPE JCCAEDWPEA: The hemodynamic alterations produced by a plastic valvular prosthesis for severe aortic insufficiency in man. J. Clin. Invest. 33: 891, 1954. CrossrefMedlineGoogle Scholar2. SARNOFFCASE SJRB: Physiologic considerations relating to the Hufnagel operation with special reference to postoperative anemia, in International Symposium on Cardiovascular Surgery. W. B. Saunders Co., Philadelphia, 1955, p. 328. Google Scholar3. STOHLMANSARNOFFCASE FSJRB: Hemolytic syndrome following insertion of a lucite ball valve prosthesis in the vascular system. Clin. Res. Proc. 3: 94, 1955. Google Scholar4. STEVENSONBAKER TDHJ: Haemolytic anaemia following insertion of Starr-Edwards valve prosthesis. Lancet 2: 982, 1964. CrossrefMedlineGoogle Scholar5. 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PIROFSKYSUTHERLANDSTARRGRISWOLD BDWAHE: Hemolytic anemia complicating aortic-valve surgery. New Eng. J. Med. 272: 235, 1965. CrossrefMedlineGoogle Scholar12. Case Records of the Massachusetts General Hospital. New Eng. J. Med. 271: 898, 1964. CrossrefMedlineGoogle Scholar13. BRODEURSUTHERLANDKOLERSTARRKIMSEYGRISWOLD MTDWRDAJAHE: Red blood cell survival in patients with aortic valvular disease and ball-valve prostheses. Circulation 32: 570, 1965. CrossrefMedlineGoogle Scholar14. : A Million Random Digits with 100,000 Normal Deviates. The Free Press of Glencoe, New York, 1955. Google Scholar15. TUFFYBROWNZUELZER PAKWW: Infantile pyknocytosis. J. Dis. Child. (Chicago) 98: 227, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, WisconsinFrom the Department of Medicine, Marquette University School of Medicine, Milwaukee, Wis.This study was supported by training grant TI AM 5162-07, the National Institutes of Health, and grant 5 MO 1 FR-0058, the Clinical Research Center, the National Institutes of Health, Bethesda, Md.This work was performed while the author was a Research Trainee in Hematology at Marquette University School of Medicine and the Milwaukee County General Hospital.Requests for reprints should be addressed to David W. Weetring, M.D., Department of Medicine, University of Wisconsin School of Medicine, Madison, Wis. 53706. 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