tbuckley/cabot-search huggingface dataset:
The independent practice association
Authors: W. De Wolf
Journal: JAMA (1995)

To the Editor.  —For the record, we would like to correct some key factual errors in the article by Dr Shenkin 1 and address some basic contradictions in his thesis.  First, Shenkin claims that we at Hill Physicians Medical Group Inc (HPMG) have demanded physician exclusivity. This is not true. Shenkin, himself a provider and shareholder/ owner in HPMG, also participates in other independent practice associations (IPAs).  Second, he refers to our use of one hospital, implying that we use it exclusively. We work with eight hospitals in the San Francisco East Bay Area in California. Our 1000 physicians in the East Bay Area are located throughout the region and not centered around Oakland and San Ramon, as incorrectly reported.  Third, he reports that HPMG  not raised its basic office visit reimbursement in 9 years! He failed to point out that HPMG has maintained fee-for-service reimbursement with no withholds
Meningococcal Infections—the Military and the Civilians
Authors: HARRY A. FELDMAN
Journal: Annals of Internal Medicine (1966)

Editorial Notes1 November 1966Meningococcal Infections—the Military and the CiviliansHARRY A. FELDMAN, M.D.HARRY A. FELDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1148 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past several years there has been a resurgence of interest in the meningococcus and the diseases it produces that sometimes has bordered on the hysterical. Several factors seem to have contributed to this widespread reaction, not the least of which was the demonstration in 1963 (1) that sulfadiazine-resistant strains ofNeisseria meningitidiscould be isolated with relative frequency from both carriers and patients in the military services. As might have been expected, this led to the finding that sulfadiazine could not be used as an effective prophylactic in populations harboring a significant number of carriers of resistant strains....References1. MILLARSIESSFELDMANSILVERMANFRANK JWEEHACP: In vivo and in vitro resistance to sulfadiazine in strains of Neisseria meningitidis. JAMA 186: 139, 1963. CrossrefMedlineGoogle Scholar2. FELDMAN HA: Meningococcal disease, 1965. JAMA 196: 391, 1966. CrossrefMedlineGoogle Scholar3. Morbidity and Mortality, no. 32, vol. 15. Communicable Disease Center, U. S. Public Health Service, 1966, p. 280. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Preventive Medicine State University of New York Upstate Medical Center Syracuse, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRational Use of Prophylactic Antibiotics in Children 1 November 1966Volume 65, Issue 5Page: 1148-1148KeywordsArmed forcesInfectious diseasesMeningococcal diseaseNeisseria meningitidisPopulation statistics Issue Published: 1 November 1966 PDF DownloadLoading ...
Violence on Television
Authors: Eli A. Rubinstein
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Dr Rothenberg's article on TV violence does an important service in bringing this issue to the attention of your readers. His call for action is to be applauded. However, as someone who was intimately involved in the operation of the Surgeon General's program of research, I must take issue with his interpretation of the "controversy" over the final report of the Scientific Advisory Committee. It is true that the networks identified seven scientists who, they believed, should not serve on the committee. However, it is a slur on the reputations of the 12 members who did serve to suggest that these seven were, by contrast, individuals "who had the most outstanding reputations and work in the field." Furthermore, the seven were not "replaced by five television network executives." Two of the committee members were full-time employees of the networks, but they are scientists, fully credentialed in this
Factors Influencing the Handling of Insulin by the Isolated Rat Kidney
Authors: Ralph Rabkin, Abbas E. Kitabchi
Journal: Journal of Clinical Investigation (1978)

The renal handling of immunoreactive insulin was studied in the isolated perfused normothermic rat kidney to determine (a) the relative contributions of glomerular clearance and peritubular clearance to the renal clearance of insulin under different conditions, (b) what metabolic factors influence the ability of tubular cells to remove insulin from the glomerular filtrate and the peritubular circulation, and (c) whether the same factors influence the luminal and contraluminal uptake of insulin.
Abstract LB-256: S6K1 mediates glycolysis and apoptosis resistance in Pten deficient cells
Authors: Preeti Tandon, Catherine A. Gallo, Shikha Khatri, David R. Plas
Journal: Cancer Research (2011)

Abstract Pten loss and subsequent Akt activation promotes cell survival in human cancer cells through activation of glycolytic metabolism and repression of pro-apoptotic factors. Because sustained glycolysis is required for Akt dependent apoptosis resistance, we investigated the downstream signaling components that mediate Akt dependent increases in glycolysis in Pten-deficient cells. Loss of the ribosomal protein S6K1 in Pten-deficient cells prevented Akt-induced glycolysis and triggered Bax translocation and commitment to apoptosis. Inactivation of S6K1 was associated with decreased expression of the pro-glycolytic HIF1α transcription factor. Restoring HIF1α expression was sufficient to restore both glycolysis and cell survival in S6K1-deficient cells. Conversely, inhibiting HIF1α expression in Pten deficient cells resulted in decreased glycolysis and cell survival, mimicking the loss of S6K1. In vivo, S6K1 deficiency delayed the development of lethal disease in the Pten fl/fl Mx-1 Cre+ model of leukemia. Thus, together the data suggest that S6K1 is a useful target for counteracting the metabolic program that supports apoptosis resistance in Pten-deficient cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-256. doi:10.1158/1538-7445.AM2011-LB-256
Surgical Treatment of Complications of Acute Myocardial Infarction
Authors: Hooshang Bolooki
Journal: JAMA (1990)

Complications of acute myocardial infarction that develop within the first 2 weeks after its onset have been associated with a poor prognosis and dismal surgical outcome. In recent years, aggressive use of hemodynamic monitoring and interventions that improve myocardial oxygen supply and demand have noticeably altered the prognosis. Urgent relief of myocardial ischemia with coronary reperfusion has had the largest impact in improving the results. Surgical treatment of mechanical and nonmechanical complications of acute myocardial infarction requires prompt decision making and expeditious implementation. Persistent left ventricular dysfunction and cardiogenic shock are the most important factors that influence the overall results. (<i>JAMA</i>. 1990;263:1237-1240)
Care service in general practice: a two-year survey.
Authors: C. B. Floyd
Journal: BMJ (1968)

After the retirement of the senior partner at the end of 1965 it was found necessary to examine ways in which the efficiency of the practice could be improved so that it could be run as a three-man partnership.The practice is conducted from a large old Victorian house, and extends for a radius of about 2 miles (3 km.) from the surgery premises in a highly populated urban area.The list size is 8,500, and has remained at this level for several years: 1,072 (12.6%) are over 65 years, and approximately 650 (7.6%) are 5 years and under.A health visitor, midwife, and district nurse are attached to the practice and work at times on the surgery premises-the health visitor at the well-baby clinic, the midwife at the two antenatal clinics, and the district nurse at her own surgery sessions each morning and two evenings a week.The surgery premises are staffed for 24 hours a day by a full-time secretary, two part-time receptionists, and a house- keeper who covers nights and week-ends.The partners in the practice each tend to follow their own interests.The senior partner looks after a large percentage of the old people, another partner has industrial appointments which take him away from the surgery for one day a week, and the third partner holds two clinical assistantships at a local hospital.
Favipiravir for children with Ebola
Authors: Naïm Bouazza, Jean-Marc Treluyer, Frantz Foissac, France Mentré, Anne-Marie Taburet, Jérémie Guedj, Xavier Anglaret, Xavier de Lamballerie, Sakoba Keïta, Denis Malvy, Pierre Frange
Journal: The Lancet (2015)
AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT
Authors: LEWIS A. GOLDEN
Journal: Annals of Internal Medicine (1937)

Article1 November 1937AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATTNEUROLOGIC MANIFESTATIONS IN "HYPOGLYCEMIC SHOCK" (SAKEL)*LEWIS A. GOLDEN, M.D.LEWIS A. GOLDEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-5-819 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPresent attempts to treat schizophrenia and other psychoses with hypoglycemia induced by large doses of insulin, afford the opportunity of observing at one's leisure, many interesting neurological manifestations seldom otherwise witnessed.Through the courtesy of Dr. John R. Ross, Superintendent of the Harlem Valley State Hospital, N. Y., and the kindness of Drs. I. Murray Rossman, William B. Cline, Jr. and O. Schwoerer of the male service and Dr. A. Goulacher and Dr. Pellens of the female service I was among those privileged to observe this phase of their work on the "Insulin Wards." The method used was that of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, Louisiana*Received for publication August 9, 1937.From the Department of Medicine, Division of Psychiatry, Tulane University Medical School, New Orleans, Louisiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByParoxysmal Dyskinesia Associated with HypoglycemiaA movement disorder as a presenting feature of recurrent hypoglycaemiaIntoxikationenInsulin reaction and the cerebral damage that may occur in diabetesNeurological observations in hypoglycemic statesNeurological Manifestations Seen During Cardiazol and Insulin Treatments 1 November 1937Volume 11, Issue 5Page: 819-822KeywordsHypoglycemiaInsulinPsychosesSchizophrenia Issue Published: 1 November 1937 PDF DownloadLoading ...
Splenic Arteriovenous Fistula With Bacterial Endarteritis and Endocarditis
Authors: Richard Quintiliani
Journal: JAMA (1970)

The combination of arteriovenous fistula, endocarditis, and endarteritis is rare. This communication adds another case of this association with the fistula and the endarteritis involving the splenic artery and vein, a previously unreported cause for a splenic arteriovenous fistula. Listening for a characteristic bruit provided much localizing information while arteriography established the exact area of the fistula. The causative organism was a coagulase-negative staphylococcus which produced large vegetations on the aortic valve.
The Physicians Who Care Plan
Authors: Ronald S. Bronow, Robert A. Beltran, Stephen C. Cohen, Paul T. Elliott, Gordon M. Goldman, Seth G. Spotnitz
Journal: JAMA (1991)

To expand health care to all Americans, the organization Physicians Who Care favors a reshaping of current U.S. health care financing structures in preference to a national health care program like Canada's. The proposal comes in five parts. First, Bronow, et al. suggest mandatory employer-provided basic coverage with high deductibles. Second, for people of limited means, high deductibles can be substituted by individual medical savings accounts, established with pretax dollars. Third, instead of being funded entirely through taxes each year, Medicare could be funded partly through medical IRAs, required for every American from his or her first year of life. Fourth, long-term care should be taken out of Medicaid, and eligibility requirements should be changed. Finally, instead of allowing insurance companies to set health benefits, scientific guidelines should be established for medical care. Bronow, et al. also recommend that patients be made fully aware of any financial incentives for physicians.
Childhood Cholesterol Screening: Contraindicated
Authors: Thomas B. Newman
Journal: JAMA (1992)

WE RECENTLY presented the case against childhood cholesterol screening.<sup>1</sup>In short, screening children, even the 25% with a family history of high blood cholesterol or early coronary artery disease, is a waste of money that is likely to do more harm than good. Resnicow et al,<sup>2</sup>in "The Case Against `the Case Against Childhood Cholesterol Screening,'" disagree with our position. They make three important points we wish to reiterate: (1) "Extrapolation of findings from... nonrepresentative adult populations to the general pediatric population should be made with extreme caution." (2) "There are many empirical questions regarding the efficacy and safety of early (universal) detection and treatment of hypercholesterolemia in children that can only be answered through controlled research." (3) "Any discussion regarding the early detection and treatment of hypercholesterolemia should be framed by the parameters of whether the ultimate gains, both medical and economic, outweigh the risks." Given their
Trans-population Analysis of Genetic Mechanisms of Ethnic Disparities in Neuroblastoma Survival
Authors: Eric R. Gamazon, Navin Pinto, Anuar Konkashbaev, Hae Kyung Im, Sharon J. Diskin, Wendy B. London, John M. Maris, M. Eileen Dolan, Nancy J. Cox, Susan L. Cohn
Journal: JNCI Journal of the National Cancer Institute (2012)

BackgroundBlack patients with neuroblastoma have a higher prevalence of high-risk disease and worse outcome than white patients. We sought to investigate the relationship between genetic variation and the disparities in survival observed in neuroblastoma.
Elevated Vascular Endothelial Growth Factor Receptor-2 Abundance Contributes to Increased Angiogenesis in Vascular Endothelial Growth Factor Receptor-1–Deficient Mice
Authors: Vivienne C. Ho, Li-Juan Duan, Chunxia Cronin, Bruce T. Liang, Guo-Hua Fong
Journal: Circulation (2012)

Background— Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1) is a potential therapeutic target for cardiovascular diseases, but its role in angiogenesis remains controversial. Whereas germline Vegfr-1 −/− embryos die of abnormal vascular development in association with excessive endothelial differentiation, mice lacking only the kinase domain appear healthy. Methods and Results— We performed Cre- lox P–mediated knockout to abrogate the expression of all known VEGFR-1 functional domains in neonatal and adult mice and analyzed developmental, pathophysiological, and molecular consequences. VEGFR-1 deficiency promoted tip cell formation and endothelial cell proliferation and facilitated angiogenesis of blood vessels that matured and perfused properly. Vascular permeability was normal at the basal level but elevated in response to high doses of exogenous VEGF-A. In the postinfarct ischemic cardiomyopathy model, VEGFR-1 deficiency supported robust angiogenesis and protected against myocardial infarction. VEGFR-1 knockout led to abundant accumulation of VEGFR-2 at the protein level, increased VEGFR-2 tyrosine phosphorylation transiently, and enhanced serine phosphorylation of Akt and ERK. Interestingly, increased angiogenesis, tip cell formation, vascular permeability, VEGFR-2 accumulation, and Akt phosphorylation could be partially rescued or suppressed by one or more of the following manipulations, including injection of the VEGFR-2 selective inhibitor SU1498, anti-VEGF-A, or introduction of Vegfr-2 +/− heterozygosity into Vegfr-1 somatic knockout mice. Conclusions— Upregulation of VEGFR-2 abundance at the protein level contributes in part to increased angiogenesis in VEGFR-1–deficient mice.
Lung collapse caused by allergic bronchopulmonary aspergillosis in non-asthmatic patients.
Authors: K E Berkin, D R Vernon, J W Kerr
Journal: BMJ (1982)

Allergic bronchopulmonary aspergillosis may occur in non-asthmatic patients FIG 1 Chest radiographs of the patient in case 1, showing (a) complete collapse of left lung at presentation; (b) re-expansion of left lung after bronchoscopy.
Intravenous Immune Globulin in Autoimmune Uveitis
Authors: Marina Karmochkine
Journal: Annals of Internal Medicine (1998)

Letters15 December 1998Intravenous Immune Globulin in Autoimmune UveitisMarina Karmochkine, MD, Michel D. Kazatchkine, MD, and Phuc Lehoang, MD, PhDMarina Karmochkine, MDHopital Broussais; Paris, FranceHopital Pitie-Salpetriere; Paris, FranceSearch for more papers by this author, Michel D. Kazatchkine, MDHopital Broussais; Paris, FranceHopital Pitie-Salpetriere; Paris, FranceSearch for more papers by this author, and Phuc Lehoang, MD, PhDHopital Broussais; Paris, FranceHopital Pitie-Salpetriere; Paris, FranceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-12-199812150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Intravenous immune globulin (IVIg) can be beneficial in several immune-mediated and inflammatory disorders [1, 2]. The administration of IVIg was recently reported to significantly reduce the necessary dose of corticosteroids in patients with severe steroid-dependent asthma, suggesting that IVIg could be used as a steroid-sparing agent in patients with chronic inflammatory conditions [3].Birdshot retinochoroidopathy is a chronic bilateral form of posterior uveitis of autoimmune origin strongly associated with HLA-A29. If untreated, it results in photophobia, night blindness, altered visual fields, and, eventually, visual loss [4]. Patients with severe birdshot retinochoroidopathy require long-term therapy with steroids or ...References1. Dwyer JM. Manipulating the immune system with immune globulin. N Engl J Med. 1992; 326:107-16. Google Scholar2. Mouthon L, Kaveri SV, Spalter SH, Lefranc C, Desai R, Kazatchkine MD. Mechanisms of action of intravenous immunoglobulin in immune-mediated diseases. Clin Exp Immunol. 1996; 104:3-9. Google Scholar3. Gelfand EW, Landwehr LP, Esterl B, Mazer B. Intravenous immune globulin: an alternative therapy in steroid-dependent allergic disease. Clin Exp Immunol. 1996; 104:61-6. Google Scholar4. Ryan SJ, Maumenee AE. Birdshot retinochoroidopathy. Am J Ophthalmol. 1980; 89:31-45. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hopital Broussais; Paris, FranceHopital Pitie-Salpetriere; Paris, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmunoglobulinsImmunosuppresseurs et immunomodulateursHuman Immunoglobulins in Intraocular InflammationIndications thérapeutiques des immunoglobulines intraveineuses 15 December 1998Volume 129, Issue 12Page: 1078-1079KeywordsBody weightCorticosteroid therapyGlobulinsHypertensionOsteoporosisPatientsSteroid therapySteroidsUveitisVisual acuity Issue Published: 15 December 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Measurement of environmental tobacco smoke exposure among adults with asthma.
Authors: M D Eisner, P P Katz, E H Yelin, S K Hammond, P D Blanc
Journal: Environmental Health Perspectives (2001)

Because the morbidity and mortality from adult asthma have been increasing, the identification of modifiable environmental exposures that exacerbate asthma has become a priority. Limited evidence suggests that exposure to environmental tobacco smoke (ETS) may adversely affect adults with asthma. To study the effects of ETS better, we developed a survey instrument to measure ETS exposure in a cohort of adults with asthma living in northern California, where public indoor smoking is limited. To validate this survey instrument, we used a passive badge monitor that measures actual exposure to ambient nicotine, a direct and specific measure of ETS. In this validation study, we recruited 50 subjects from an ongoing longitudinal asthma cohort study who had a positive screening question for ETS exposure or potential exposure. Each subject wore a passive nicotine badge monitor for 7 days. After the personal monitoring period, we readministered the ETS exposure survey instrument. Based on the survey, self-reported total ETS exposure duration ranged from 0 to 70 hr during the previous 7 days. Based on the upper-range boundary, bars or nightclubs (55 hr) and the home (50 hr) were the sites associated with greatest maximal self-reported exposure. As measured by the personal nicotine badge monitors, the overall median 7-day nicotine concentration was 0.03 microg/m(3) (25th-75th interquartile range 0-3.69 microg/m(3)). Measured nicotine concentrations were highest among persons who reported home exposure (median 0.61 microg/m(3)), followed by work exposure (0.03 microg/m(3)), other (outdoor) exposure (0.025 microg/m(3)), and no exposure (0 microg/m(3); p = 0.03). The Spearman rank correlation coefficient between self-reported ETS exposure duration and directly measured personal nicotine concentration during the same 7-day period was 0.47, supporting the survey's validity (p = 0.0006). Compared to persons with no measured exposure, lower-level [odds ratio (OR) 1.9; 95% confidence interval (CI), 0.4-8.8] and higher-level ETS exposures (OR 6.8; 95% CI, 1.4-32.3) were associated with increased risk of respiratory symptoms. A brief, validated survey instrument can be used to assess ETS exposure among adults with asthma, even with low levels of exposure. This instrument could be a valuable tool for studying the effect of ETS exposure on adult asthma health outcomes.
THE DISTRIBUTION OF SODIUM AND POTASSIUM IN MAN 1
Authors: Norman Deane, Homer W. Smith
Journal: Journal of Clinical Investigation (1952)

Simultaneous measurements of body water dis- tribution and total body electrolyte by the isotope dilution technique permit the calculation of total intracellular electrolyte and average intracellular electrolyte concentration.The application of this principle to the measurement of intracellular so- dium and potassium in the dog has been reported by Levitt and Gaudino (1).The purpose of this study is to provide comparable data on man. METHODSTotal body water was determined by the volume of distribution of antipyrine,2 corrected for metabolism, by the method of Soberman, Brodie, Levy, Axelrod, Hollander and Steele (2).In view of indirect evidence which suggests that antipyrine may not reach maximal distribution in two hours (3), we have preferred, for extrapolation to zero time in correction for metabolism, to use the plasma concentrations from three-to seven or eight hours after injection.Extracellular fluid was measured by the maximal vol- ume of distribution of sucrose as determined by the cali- brated infusion technique (4).Intracellular water was calculated as the difference between the antipyrine and sucrose volumes of distribution.Cellular mass was cal-
SEVERE DECLINE IN PLATELET COUNT IN PATIENTS TREATED BY PERCUTANEOUS AORTIC VALVE REPLACEMENT IS ASSOCIATED WITH A HIGH IN-HOSPITAL DEATH RATE
Authors: Danny Dvir, Itsik Ben-Dor, Israel Barbash, Rebecca Torguson, salem badr, Gabriel Sardi, Ana Laynez Carnicero, Lowell Satler, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2012)