tbuckley/cabot-search huggingface dataset:
Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models
Authors: Ju Hee Ryu, Jin Hee Na, Ho Kyung Ko, Dong Gil You, Subin Park, Eunsung Jun, Ho Jun Yeom, Deok Ho Seo, Jae Hyung Park, Seo Young Jeong, In-San Kim, Byung-Soo Kim, Ick Chan Kwon, Kuiwon Choi, Kwangmeyung Kim
Journal: Biomaterials (2013)
Echocardiography of Pericarditis
Authors: RAVI PRAKASH
Journal: Annals of Internal Medicine (1976)

Comments1 September 1976Echocardiography of PericarditisRAVI PRAKASH, M.D., F.A.C.P.RAVI PRAKASH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-395_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: It is important to recognize the conditions leading to a false-positive diagnosis of pericardial effusion by echocardiographic techniques (1-3). The echocardiogram shown in the report of Liedtke, DeJoseph, and Zelis (Ann Intern Med 84:573-574, 1976) may have another interpretation and may not be an example of a falsely positive diagnosis of pericardial effusion. To confirm pericardial effusion and to differentiate the echo-free space from pleural fluid and an enlarged left atrium, it would have been helpful to obtain a scan from the region of the left ventricle toward the left atrium. The echo-free space most likely represents...References1. RATSHINSMITHHOOD RMW: Possible false-positive diagnosis of pericardial effusion by echocardiography in presence of large left atrium. Chest 65:112-114, 1974 CrossrefMedlineGoogle Scholar2. PRAKASHKINGARONOW RJW: Enlarged left atrium causing possible false-positive echocardiographic diagnosis of pericardial effusion. Angiology 27:219-222, 1976 CrossrefMedlineGoogle Scholar3. FEIGENBAUM H: Pericardial effusion, in, Echocardiography. Philadelphia, Lea and Febiger, 1972, pp. 175-176 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RAVI PRAKASH, M.D., F.A.C.P.Affiliations: Long Beach VA Hospital Long Beach, CA 90822 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1976Volume 85, Issue 3Page: 395-396KeywordsEchocardiographyLeft atriumLeft ventricle ePublished: 1 December 2008 Issue Published: 1 September 1976 PDF downloadLoading ...
Newfound genetic defect hints at clues for developing novel antimalarial agents
Authors: A. A. Skolnick
Journal: JAMA (1993)

A RECENTLY identified genetic defect responsible for egg-shaped red blood cells in certain Asian populations may help scientists develop novel antimalarial agents. The defect, which makes red blood cell membranes too rigid for malarial parasites to gain entry, appears harmless to humans who are heterozygous, says Jiri Palek, MD, professor of medicine at Tufts University Medical School and chair of biomedical research at St Elizabeth Hospital, Boston, Mass. "In tropical areas of Southeast Asia, where malaria remains a prevalent health threat, large segments of the population enjoy a resistance to malaria due to the condition called ovalocytosis," Palek says. "It is one of the few genetic abnormalities that, as far as we know, is entirely beneficial to those who carry it." The resistance to malaria associated with the inheritance of egg-shaped red blood cells set Palek and his colleagues to look for the underlying molecular defect. They found it in
A Case of Rodent Ulcer Treated with Radium
Authors: G. Sichel
Journal: BMJ (1904)

~~~~~~~~~~~~~~~~~~~. ..KWIC" theh it would be reasonable to hope that we might be able to arrest the progress of the whole.July 3'oth.Two tubes were applied to the upper lip for fifty minutes, on July 31St for forty minutes, and on August ist for forty minutes.In addition I gave her some thorium nitrate encldsed in " oil silk "'and guttapercha outside it, to be worn as a pad in the cavity; a piece of lint was interposed between this pad and the parts.August 3rd.Two tubes applied for forty and forty-five minutes to different parts.Several applications were made subsequently, and on August 20th, having obtained some more tubes, but not of such good quality as the first, these were also used, so that on this date four tuibes were applied for an hour and a pad of thorium hydroxide given for the- patient to wear.The hydroxide is more powerful than the nitrate, and is not deliquescent.As Dr. Powell is joining me in publishing this case with more details later on it will suffice at present to state the progress made.On September ist three tubes were applied for one hour in the fore-
On the Use of the Turkish Bath in Albuminuria
Authors: E. Morris
Journal: BMJ (1871)

THE BRITI-SH MEDICAL _OURNAL.193 whereas the very opposite to this is the generally admitted fact.Hemorrhage to any extent short of causing exhaustion and prostration is, in my experience, and I believe also in the experience of most observers, rather salutary than otherwise, tending to relieve the patient, and to render the disease more chronic, both by removing local congestion and inflammation, and by separating, to a greater or less ex- tent, diseased or tuberculous blood.Nature in such cases appears to do in her own way internally what the physician often does in his way externally by local depletion.I am far, however, from denying that blood escaping into the lungs in large quantity is, from its mere pres- sure and the obstruction which it occasions, a frequent source of distress to the patient, and of temporary aggravation of disease.I am merely maintaining that it is not an original source of phthisis; and that, when it happens in the progress of consumption, it is not a new focus for the ,development of tubercle.[To be coittinu ged.
Comparison of endoscopic ultrasonography and conventional endoscopy for prediction of depth of tumor invasion in early gastric cancer
Authors: J. Choi, S. Kim, J. Im, J. Kim, H. Jung, I. Song
Journal: Endoscopy (2010)

Background and study aims: This study aimed to compare the diagnostic accuracy of endoscopic ultrasonography (EUS) with that of conventional endoscopy for staging depth of invasion (T staging) in early gastric cancer.
The influence of daily dish-washing with synthetic detergent on human skin
Authors: G. KEIN, G. GUBAUER, P. FITSCH
Journal: British Journal of Dermatology (1992)

Summary The effects of regular dish-washing on the stratum corneum barrier function, as determined by transepidermal water loss (TEWL), and objective and subjective skin parameters, were investigated in a ‘use test’ performed by 18 healthy volunteers. Hands were soaked in a 0.05% solution of a commercial dish-washing product (three times/day, for 15 min, at 37°C) over a period of 3 weeks; one hand was unprotected and the other was protected with a commercial rubber glove. TEWL increased in 13/18 volunteers by more than 25% above baseline on exposed hands within the first 2 weeks of the study. Objective skin signs (erythema, scaling, fissures) and subjective symptoms (itching, dryness, smarting) occurred almost exclusively in subjects with substantial TEWL increases and were most prominent 1–2 weeks following peak TEWL values. There was a highly significant correlation between cumulative relative symptom scores and TEWL changes. TEWL increase and symptom scores were not correlated with a history of inhalant allergy and/or elevated serum IgE levels. Three volunteers, who had shown the highest increase of TEWL values and the most intense clinical reactions to the detergent were subjected to a control experiment in which one hand was soaked in warm tap-water following the same experimental protocol. No significant effects on TEWL values or skin symptoms were observed. We conclude that regular exposure to low concentrations of detergents as used for dish-washing is capable of inducing skin lesions in a substantial proportion of individuals.
Complementary medicine. Elderly people use complementary treatments.
Authors: C Aus
Journal: BMJ (1993)

vascular granulomatosis or pulmonary "mainline" granulomatosis.'Symptoms include cough and dyspnoea, and in severe cases pulmonary hypertension is a consequence.Talc (magnesium trisilicate), a constituent of pentazocine, methyl- phenidate, and tripelennamine (tablets which are commonly injected) seems to be the agent most often implicated in such cases.Our evidence suggests that chronic misuse of injected temazepam may produce a similar pulmonary syndrome.We recently examined the lungs of a 31 year old drug misuser who died suddenly after an electromechanical dissociation cardiac arrest.He had admitted injecting a suspension of temazepam
More than 1000 were injured in latest violence in Gaza
Authors: A. Gulland
Journal: BMJ (2012)

<b>Background:</b> Lung diffusion capasity for carbon monoxide is determined with structural and functional characteristics of the lung performance. Elite athletes tend to have higher DLCO values. <b>Aim:</b> To evaluate the anthropometric and training factors influence on carbon monoxide lung diffusion capacity (DLCO) and on transfer coefficient (KCO) in elite athletes, by using the logistic regression model. <b>Methods:</b> From November 2012 to September 2015, 70 randomly selected male Caucasian elite athletes were analyzed. They came to be regularly screened for the respiratory diseases. DLCO and KCO were measured by the single breath method standardized technique; anthropometric values were measured as standing body height (cm) and body weight (kg). <b>Results:</b> The implemented logistic regression model has shown that only the combination of training frequency per week and the weekly amount of training expressed in hours had positive influence on DLCO. Predictors for KCO were not identified. This model was found to be excellent according to classification table, providing 80,0% of agreement for DLCO and 71,0% for KCO, at a cut off value of p=0.50. A set of goodness of fit tests was performed in order to further test the model, and all were nonsignificant, showing that it has correctly predicted the real data: Hosmer and Lemeshow test (p=0.866); Cox and Snell R2 (p=0.420) and Nagelkerke R2 (p=0.561). <b>Conclusion:</b> Training factors have shown to have positive influence on DLCO. Anthropometric features were not found to be significant predictors for DLCO. Further studies are encouraged.
Potential of Blood Eosinophils, Eosinophil-Derived Neurotoxin, and Eotaxin-3 as Biomarkers of Eosinophilic Esophagitis
Authors: Michael R. Konikoff, Carine Blanchard, Cassie Kirby, Bridget K. Buckmeier, Mitchell B. Cohen, James E. Heubi, Philip E. Putnam, Marc E. Rothenberg
Journal: Clinical Gastroenterology and Hepatology (2006)
Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease
Authors: Jean-Claude Chomel, Marie-Laure Bonnet, Nathalie Sorel, Angelina Bertrand, Marie-Claude Meunier, Serge Fichelson, Michael Melkus, Annelise Bennaceur-Griscelli, François Guilhot, Ali G. Turhan
Journal: Blood (2011)
Calcium in atrial fibrillation — pulling the trigger or not?
Authors: Nieves Gomez-Hurtado, Björn C. Knollmann
Journal: Journal of Clinical Investigation (2014)

Atrial fibrillation (AF) is the most common sustained arrhythmia disease. Current drug- and surgical-based therapies are ineffective in about 40% to 50% of AF patients; therefore, there is a great need to better understand the underlying mechanisms of this disease and identify potential therapeutic targets. In this issue of the JCI, Greiser and coworkers discovered that atrial remodeling in response to sustained tachycardia silences Ca2+ signaling in isolated rabbit and human atrial myocytes. This Ca2+ release silencing was attributable to a failure of subcellular propagated Ca2+ release due to an increased cytosolic buffering strength. The results from this study challenge the current paradigm that Ca2+ release instability underlies AF. Instead, Ca2+ silencing could be protective against the massive cellular Ca2+ loading that occurs during chronic AF.
Lack of hepatic transferrin receptor expression in hemochromatosis
Authors: Raf Sciot, Alan C. Paterson, Joost J. Van Den Oord, Valeer J. Desmet
Journal: Hepatology (1987)

The major part of hepatocellular iron is derived from uptake of transferrin-bound iron by means of nonspecific fluid-phase endocytosis and specific, saturable binding on high-affinity transferrin receptors. We investigated the expression of transferrin receptors on hepatocytes in liver biopsies of 22 cases of hemochromatosis (21 primary hemochromatosis and 1 secondary hemochromatosis), using immunohistochemical demonstration of the human transferrin receptor with the specific monoclonal antibody OKT9. Fifty liver biopsies (normal and pathological) without demonstrable iron storage (Perls' stain negative) served as controls. In the controls, membranous and/or cytoplasmic transferrin receptor expression was always present on hepatocytes, albeit in variable numbers and patterns without obvious relation to the underlying liver disease. In 19 of 22 hemochromatosis cases with severe iron overload, OKT9 immunoreactivity on hepatocytes was completely absent. Three hemochromatosis cases showed few hepatocytes positive for OKT9. One showed mild iron overload, while the second, a successfully treated case, was free of iron. The remaining hemochromatosis case was a known alcoholic with severe iron overload. Since OKT9 binding to the transferrin receptor is not blocked by previous binding of transferrin, the findings show that in advanced hemochromatosis hepatocytes do not express transferrin receptors. This finding is in keeping with the inverse relation between transferrin receptor expression and exogenous iron supply in various cell cultures. These results indicate that in hemochromatosis, apparently as a result of progressive iron overload, transferrin receptor expression on hepatocytes disappears. This leaves the hepatocytes with a nonsaturable mechanism for uptake of transferrin-bound iron (fluid-phase pinocytosis) and with uptake of potentially more toxic forms of nontransferrin-bound iron, which may represent up to 30% of serum iron in fully established hemochromatosis.
PRIMARY PAYER STATUS AND OUTCOMES IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION
Authors: Dhaval Kolte, Sahil Khera, Wilbert Aronow, Marjan Mujib, Chandrasekar Palaniswamy, Diwakar Jain, Sachin Sule, William Frishman, Ali Ahmed, Gregg Fonarow, Julio Panza
Journal: Journal of the American College of Cardiology (2014)
Palliative Care — A Shifting Paradigm
Authors: Amy S. Kelley, Diane E. Meier
Journal: New England Journal of Medicine (2010)

Palliative care focuses on relieving suffering and achieving the best possible quality of life for patients and their family caregivers. It involves the assessment and treatment of symptoms; support for decision making and assistance in matching treatments to informed patient and family goals; practical aid for patients and their family caregivers; mobilization of community resources to ensure a secure and safe living environment; and collaborative and seamless models of care across a range of care settings (i.e., hospital, home, nursing home, and hospice). Palliative care is provided both within the Medicare hospice benefit (hospice palliative care) and outside it (nonhospice . . .
William Bryan Jennett
Authors: Caroline Richmond, Graham Teasdale
Journal: BMJ (2008)

Pioneer academic neurosurgeon and world expert on brain damage prognosis

Bryan Jennett devised, with colleagues, the Glasgow coma scale, a tool used worldwide to assess states of consciousness, and the Glasgow outcome scale for patients with head injury. He defined the persistent vegetative state. He established the criteria for brain death and wrote lucidly and incisively on ethical issues, including the appropriate use of high technology. Combining a career as a neurosurgeon with laboratory and clinical research, he made Glasgow a world centre for neurosurgery. He was an inspirational teacher and trained many of the next generation of academic neurosurgeons.

Bryan was born in Twickenham, Middlesex, the son of a civil servant. He was educated at King’s College School, Wimbledon, and King George V School in Southport. He entered Liverpool University on a scholarship and qualified top of his class in 1949, having been president of the medical students’ society and of the National British Medical Students’ Association.

He became house physician to Lord Cohen of Birkenhead, who steered him towards neurosurgery. Later, in Oxford, …
ST. GEORGE'S HOSPITAL: SCIRRHUS OF PYLORUS: EXTENSIVE COLLOID DEPOSIT IN ABDOMEN: DEATH IN BOTH CASES
Authors: W. E. Page
Journal: BMJ (1856)

She stated that she had suffered for a very long time from indigestion, which had been worse for three months.Her bowels had not been opened for sixteen days, and she spoke of constant vomiting; but this symptom did not manifest itself after she came under our notice.She slept but little, and had much burning pain at the epigastrium.Her pulse was quiet; tongue clean and moist.In the track of the transverse colon was a hard moveable mass which had not previously attracted her attention.September 19th.After enemata and purgatives, the bowels acted: the stools being at first scanty and lumpy, but subsequently quite healthy.The epigastric pain was allayed by a mixture of hydrocyanic acid with soda.In
ANTITOXIN—SOME MEDICO-LEGAL ASPECTS OF ITS USE.
Authors: JAMES L. TAYLOR
Journal: JAMA (1897)

In the issue of theJournalof February 27, Dr. Chas. T. McClintock of Detroit discusses, in an admirable scientific paper, one of the most intensely interesting questions now before the medical profession, viz.: the cause of death in hypodermic serum medication. The doctor shows conclusively that the injection of air along with the serum is not an adequate explanation of the reported accidents. He also points out that carbolic acid or trikresol used as a preservative of the serum is still less likely to be causative of these mishaps, and that experiments seem to show that the serum<i>per se</i>is not responsible. What the true cause may be, the doctor believes to be at present unanswerable, and prefers to give definite form to our ignorance by calling it "shock." The profession will certainly not remain satisfied with thus merely giving a name to our ignorance. The phenomena heretofore
Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: Regulation by a polyphenol -(−)-epigallocatechin-3-gallate
Authors: Jia Liu, Ying Tang, Zhihui Feng, Chen Hou, Hui Wang, Jiong Yan, Jing Liu, Weili Shen, Weijin Zang, Jiankang Liu, Jiangang Long
Journal: Metabolism (2014)
Psychology of limb loss
Authors: M. Deane
Journal: BMJ (1989)

After consultation with their professional body pharmacists were individually canvassed by the director general of health to join the scheme, for which a management plan had been prepared.Specially designed equipment had been produced and was available from the outset.Participating pharmacies order 20 exchange packs at a time, which are delivered in a purpose built cardboard box that doubles as the disposal unit.Each exchange pack consists of a cylindrical plastic container with screw top, ten 3 ml syringes with 26 gauge needles attached, a packet of three condoms with illustrated instruction sheet, and a general information leaflet.Pharmacists charge a service fee for selling the packs.Trhis is less for a customer who returns the
The ontogeny of antigen-specific T cells.
Authors: A M Silverstein, S Segal
Journal: The Journal of Experimental Medicine (1975)

Although the fetal lamb is unable to form circulating antiovalbumin antibodies until about 120 days of gestation, ovalbumin-specific helper T cells can be stimulated to function at an earlier age. This would suggest that the critical event responsible for the precise sequential maturation of immunologic competence to different antigens at different developmental stages is not the first appearance of specific receptors on immunocytes. Alternative explanations of this phenomenon are discussed.
The histone deacetylase inhibitor ITF2357 has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells
Authors: J Golay, L Cuppini, F Leoni, C Micò, V Barbui, M Domenghini, L Lombardi, A Neri, A M Barbui, A Salvi, P Pozzi, G Porro, P Pagani, G Fossati, P Mascagni, M Introna, A Rambaldi
Journal: Leukemia (2007)
738–6 Recanalization of Chronically Occluded Bypass Grafts: The Effect of Angioplasty Site Following Extended Urokinase Infusion on 6 Month Patency
Authors: Joseph R. Hartmann, Louis S. McKeever, William W. O’Neill, Christopher J. White, Patrick J. Whitlow, Elaine L. Enger
Journal: Journal of the American College of Cardiology (1995)
Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression
Authors: Kimberley D. Bruce, Felino R. Cagampang, Marco Argenton, Junlong Zhang, Priya L. Ethirajan, Graham C. Burdge, Adrian C. Bateman, Geraldine F. Clough, Lucilla Poston, Mark A. Hanson, Josie M. McConnell, Christopher D. Byrne
Journal: Hepatology (2009)

Nonalcoholic fatty liver disease (NAFLD) describes an increasingly prevalent spectrum of liver disorders associated with obesity and metabolic syndrome. It is uncertain why steatosis occurs in some individuals, whereas nonalcoholic steatohepatitis (NASH) occurs in others. We have generated a novel mouse model to test our hypothesis: that maternal fat intake contributes to the development of NAFLD in adult offspring. Female mice were fed either a high-fat (HF) or control chow (C) diet before and during gestation and lactation. Resulting offspring were fed either a C or a HF diet after weaning, to generate four offspring groups; HF/HF, HF/C, C/HF, C/C. At 15 weeks of age, liver histology was normal in both the C/C and HF/C offspring. Kleiner scoring showed that although the C/HF offspring developed nonalcoholic fatty liver, the HF/HF offspring developed NASH. At 30 weeks, histological analysis and Kleiner scoring showed that both the HF/C and C/HF groups had NAFLD, whereas the HF/HF had a more severe form of NASH. Therefore, exposure to a HF diet in utero and during lactation contributes toward NAFLD progression. We investigated the mechanisms by which this developmental priming is mediated. At 15 weeks of age, hepatic mitochondrial electron transport chain (ETC) enzyme complex activity (I, II/III, and IV) was reduced in both groups of offspring from HF-fed mothers (HF/C and HF/HF). In addition, measurement of hepatic gene expression indicated that lipogenesis, oxidative stress, and inflammatory pathways were up-regulated in the 15-week-old HF/C and HF/HF offspring. Conclusion: Maternal fat intake contributes toward the NAFLD progression in adult offspring, which is mediated through impaired hepatic mitochondrial metabolism and up-regulated hepatic lipogenesis. (HEPATOLOGY 2009.)
Edward Jarvis and the Medical World of 19th-Century America
Authors: Marjorie C. Meehan
Journal: JAMA (1978)

Although he made no spectacular discoveries and is almost forgotten today, Edward Jarvis achieved a considerable reputation in the 1860s as a statistician, psychiatrist, and propagandist for public health. His training, tradition, and attitude toward medicine were different from those of most physicians today, but he tried to cope with many of the same problems with which we are still struggling. Jarvis was born in Concord, Mass, in 1803 and grew up in that smalltown center of plain living and high thinking. At home and at Harvard College, he was firmly indoctrinated in moral philosophy, unitarianism, belief in the perfectibility of man, the expectation of a harmonious society led by an educated and moral elite. He saw no incompatibility between science and religion, but his view of science included observation and classification rather than laboratory investigation or experimentation. Although contemporary with Virchow and Pasteur, he paid little attention to cellular