Adverse Reactions to Factor VIII Infusions
Authors: M. Elaine Eyster, Herbert S. Bowman, Judy N. Haverstick
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 August 1977Adverse Reactions to Factor VIII InfusionsM. ELAINE EYSTER, M.D., F.A.C.P., HERBERT S. BOWMAN, M.D., F.A.C.P., JUDY N. HAVERSTICK, R.N.M. ELAINE EYSTER, M.D., F.A.C.P.Search for more papers by this author, HERBERT S. BOWMAN, M.D., F.A.C.P.Search for more papers by this author, JUDY N. HAVERSTICK, R.N.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-2-248_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a 15-month period during which time 4 700 000 units of factor VIII were used by 70 hemophiliacs known to us, fifteen adverse reactions were reported. Excluding surgical use, this represents an average of 40 000 factor VIII units per patient treated per year. Ten reactions occurred in 53 patients (19%) receiving freeze-dried concentrates; five occurred in 17 patients (29%) receiving cryoprecipitate.Anaphylactoid reactions consisting of severe bronchospasm, dyspnea, and substernal pain or hypotension, or both, occurred in five patients, four of whom received concentrates and one of whom received cryoprecipitate. All responded promptly to adrenalin... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. ELAINE EYSTER, M.D., F.A.C.P.; HERBERT S. BOWMAN, M.D., F.A.C.P.; JUDY N. HAVERSTICK, R.N.Affiliations: The Harrisburg-Hershey Hemophilia Center The Pennsylvania State University College of Medicine Hershey, PA 17033 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA rare case of an anaphylactic reaction to plasma and recombinant blood coagulation factor VIII in a child with severe hemophilia AHémophilie : physiopathologie et bases moléculairesPlasma protein variations in hemophiliacs receiving factor replacement therapyA post-marketing safety and efficacy assessment of a monoclonal antibody purified high-purity factor VIII concentrateSafety aspects in the manufacturing of plasma-derived coagulation factor concentratesSome characteristics of aggregates of IgG and plasma proteins in heat-treated factor VIII concentratesPrimary wound closure in haemophiliacs undergoing dental extractionsMild Hemophilia A as a Cause of Bleeding in Dermatologic SurgeryImmunmodulierende Eigenschaften von Faktor VIII-KonzentratenComplexes of IgG and Plasma Proteins in Factor VIII Preparations - a Possible Cause of Adverse ReactionsChanges in plasma haptoglobin and alpha-2-macroglobulin in hemophiliacs receiving factor replacement therapyEvidence that less replacement therapy is required for dental extractions in hemophiliacsImmune complexes in hemophiliaAnaphylactic reactions following infusion of factor VIII in a patient with classic hemophiliaPulmonary function abnormalities after infusion of antihemophilic factor (AHF) concentratesBlood and blood productsAdverse Reactions with Factor VIIIWILLIAM G. HOCKING, M.D. 1 August 1977Volume 87, Issue 2Page: 248-248KeywordsAdverse reactionsDyspneaHypotension ePublished: 1 December 2008 Issue Published: 1 August 1977 PDF downloadLoading ...