tbuckley/cabot-search huggingface dataset:
Atrial Myxoma Mimicking Lyme Disease
Authors: Francesco Drago
Journal: Annals of Internal Medicine (1994)

Letters15 April 1994Atrial Myxoma Mimicking Lyme DiseaseFrancesco Drago, MD, Guido Nazzari, MD, and Franco Crovato, MDFrancesco Drago, MDChiarvari Hospital; Chiavari, Gensa; ItalySearch for more papers by this author, Guido Nazzari, MDChiarvari Hospital; Chiavari, Gensa; ItalySearch for more papers by this author, and Franco Crovato, MDChiarvari Hospital; Chiavari, Gensa; ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-8-199404150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We report an unusual case in which misinterpretation of clinical or serologic findings led to overdiagnosis and overtreatment of Lyme borreliosis.In October 1992, a 46-year-old man developed multiple, slowly enlarging annular erythematous lesions on his legs. These were accompanied by fatigue, headache, low-grade fever, myalgias, and arthralgias. Because of a history of insect bites, an enzyme-linked immunosorbent assay (ELISA) for Lyme antibody was done. The test result was negative, and no laboratory test abnormalities were found. In December, he was admitted to a neurology department because of paresis of his right median nerve; cutaneous lesions and ...References1. Steere AC, Taylor E, McHugh GL, Logigian EL. The overdiagnosis of Lyme disease. JAMA. 1993; 269:1812-6. Google Scholar2. Peters MN, Mall RJ, Cooley DA, Garcia E. The clinical syndrome of atrial myxoma. JAMA. 1974; 230:695-701. Google Scholar3. Abelc DC, Anders KH. The many faces and phases of borreliosis. J Am Acad Dermatol. 1990; 23:401-10. Google Scholar4. Atherton DJ, Pitcher DW, Wells RS, MacDonald DM. A syndrome of various cutaneous pigmented lesions, myxoid neurofibromata and atrial myxoma: the NAME syndrome. Br J Dermatol. 1980; 103: 421-9. Google Scholar5. Byrd WE, Matthews OP, Hunt RE. Left atrial myxoma presenting as systemic vasculitis. Arthritis Rheum. 1980; 23:240-3. Google Scholar Author, Article, and Disclosure InformationAffiliations: Chiarvari Hospital; Chiavari, Gensa; Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAtrial MyxomaCardiovascular Manifestations of Lyme Disease 15 April 1994Volume 120, Issue 8Page: 696KeywordsEnzyme linked immunosorbent assayFatigueLaboratory testsLesionsLyme diseaseNeurologyResearch laboratoriesThoraxTicksVasculitis Issue Published: 15 April 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Sudden and Concerning Increase in the Use of Electronic Brachytherapy for Skin Cancer
Authors: Eleni Linos, Marta VanBeek, Jack S. Resneck
Journal: JAMA Dermatology (2015)

The authors of this Viewpoint caution against expanded use of electronic surface brachytherapy for skin cancer because of the paucity of safety and efficacy data with long enough follow-up—especially when effective, safe, and lower-cost treatments already exist for most tumors.
Os subtibiale mistaken for a recent fracture.
Authors: A Coral
Journal: BMJ (1986)

Une observation: douleur et gonflement au niveau de la malleole interne apres un traumatisme. La radiographie montre un fragment osseux arrondi qui est interprete comme une fracture, mais il n'y a pas d'hematome et la «reduction»-cerclage est inefficace. En realite il s'agit d'un os accessoire. Ces os sont frequemment trouves au niveau du pied; leur forme arrondie devrait les faire reconnaitre
Obituary Listing
Authors: Douglas P. Beall
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of endothelium-derived relaxing factor enhances endothelin-mediated vasoconstriction.
Authors: A Lerman, E K Sandok, F L Hildebrand, J C Burnett
Journal: Circulation (1992)

The endothelium possesses the ability to modulate vascular tone by the release of vasodilators and vasoconstrictors, among them endothelium-derived relaxing factor (EDRF) and endothelin (ET). Abnormalities in EDRF generation have been demonstrated in various cardiovascular pathophysiological states. Moreover, a twofold increase in plasma ET concentration was reported in these disease states. Recent in vitro studies have suggested the interaction between these two endothelium-derived substances, suggesting that imbalance between the two may contribute to alternation in vascular tone characteristic of these disease states. Thus, the hypothesis of this study was that inhibition of endogenous EDRF will enhance the vasoconstrictor response to a twofold increase in plasma ET concentrations.Experiments were conducted in three groups of anesthetized dogs. In group 1, ET-1 was infused intravenously to double circulating ET concentrations. Group 2 received both ET and NG-monomethyl L-arginine (L-NMMA), a competitive inhibitor of EDRF generation, and group 3 received a continuous infusion of L-NMMA alone. Twofold increase in plasma ET concentrations was characterized by an increase in systemic and renal vasoconstriction. The inhibition of EDRF markedly enhanced the vasoconstriction to ET specifically involving the systemic, pulmonary, coronary, and renal arterial circulations.The present study demonstrates that inhibition of endogenous EDRF augments the vasoconstrictor property of ET and supports a functional role for the balance between endothelium-derived vasodilating and vasoconstricting factors in the regulation of vascular tone.
OFFSET OF TICAGRELOR’S EFFECT ON ENDOTHELIAL FUNCTION AS ASSESSED WITH PERIPHERAL ARTERIAL TONOMETRY (ENDOPAT ASSAY)
Authors: Ioanna Xanthopoulou, Chrysoula Vogiatzi, Theodora Bampouri, Athina Chasapi, Periklis Davlouros, George Hahalis, Dimitrios Alexopoulos
Journal: Journal of the American College of Cardiology (2015)
Endoscopic and histological findings in subjects with and without dyspepsia.
Authors: S J Middleton, J O Hunter
Journal: BMJ (1991)

services authority because she believed that I should provide the "morning after pill" under my agreement to provide contraceptive services to her.It was only at the informal complaints procedure that the subject was clarified, and no further action was taken.I was advised, however, that I should give patients specific instructions on where to obtain a second opinion and therefore the drugs they demand, the analogy being that I should instruct someone with an injury how
Peritoneal Dialysis in Acute Renal Failure — Why the Bad Outcome?
Authors: John T. Daugirdas
Journal: New England Journal of Medicine (2002)

In contrast to the situation of patients receiving maintenance dialysis, in which information from large, standardized data bases may give us insight into potential management strategies, when it comes to devising treatment approaches to patients with acute renal failure, we are sailing in stormy waters without beacons or buoys. Mortality rates among patients with acute renal failure can be quite high, but this diagnosis encompasses a broad mix of patients. In the case of a patient who is an appropriate candidate for renal-replacement therapy, four questions must be answered: When should renal-replacement therapy be started? What type should be used? . . .
Fever of Unknown Origin Due to Lymphogranuloma Venereum
Authors: Norton M. Luger
Journal: New England Journal of Medicine (1948)

LYMPHOGRANULOMA venereum infection is a localized suppurative process involving the inguinal, femoral and pelvic lymph nodes and the rectum. Although systemic symptoms are common in this disease, prolonged fever is rare. This infection is therefore not usually thought of in the differential diagnoses of febrile conditions. Fever, sweats, headache, tachycardia or relative bradycardia, joint and muscle pains, malaise and anorexia are frequent but, as a rule, cause little concern to the patient. Some cases, however, are so severe that the lymphadenitis appears to be of minor importance in the face of a generalized infection. When generalized symptoms predominate and the . . .
P382Cyclic guanosine monophosphate compartmentation in vascular smooth muscle cells
Authors: J Feiteiro, I Verde, E Cairrao
Journal: Cardiovascular Research (2014)

Cyclic nucleotide-gated (CNG) channels are usually expressed in photoreceptors and in olfactory neurons sensory. They open by the direct binding of cyclic nucleotides, cAMP and cGMP. The cyclic guanosine monophosphate (cGMP) synthesis is controlled by two types of guanylyl cyclases (GC) that differ in their cellular location and activation by specific ligands: a particular CG present at the plasma membrane, which is activated by natriuretic peptides such as atrial natriuretic pepetide (ANP); and a soluble GC present in the cytosol and activated by nitric oxide (NO). NO and ANP use cGMP as second messenger, there are many instances in which activation of particular and soluble GC leads to different functional effects, one explication for the different functional effects is that cGMP rises in specifc subcellular locations, regulating different targets in different parts of the cell. Recent studies performed by our group in HUA smooth muscle cells demonstrated that ANP increases cGMP levels by activating particulate GC and NO increases cGMP levels by activating soluble GC. In this sense, the aim of this work is to analyze the compartmentalization of the cGMP at the vascular level using cells infected with an adenovirus containing the CNG channels gene. The whole cell configuration of patch clamp technique was used to measure the signal activation of CNG channels, which are activated by cGMP. HUA smooth muscle cells were infected with WT CNGA2 encoding adenovirus. Some drugs were used to analyze the compartmentalization: ANP, SNP (sodium nitroprusside), IBMX (3-isobutyl-1-methylxanthine) (nonselective phosphodiesterase inhibitor), To-156 (specific phosphodiesterase 5 inhibitor), cilostamide (specific phosphodiesterase 3 inhibitor) and Sp-8 (an analogue of the natural signal molecule cyclic GMP). ANP and SNP stimulated, with different intensity, the CNG current. The particulate cGMP pool induced by ANP seems to be controled by the PDE5 and PDE3. Moreover, the administration of SNP seems to created two separated polls, one localized next to the plasma membrane, that is controlled by the PDE5 and PDE3, and other poll that is localized inside (in the middle) of the cells and is regulated by PDE3. Differential spatial and temporal distributions of cGMP may therefore contribute to the specific effects of natriuretic peptides and NO donors on vascular function.
Abstract 3995: C-terminal fragment of prostate apoptosis response-4 (Par-4) generated by caspase-3 cleavage induces apoptosis in cancer cells
Authors: Parvesh Chaudhry, Mohan Singh, Sophie Parent, Eric Asselin
Journal: Cancer Research (2012)

Abstract Prostate apoptosis response-4 (Par-4) is a ubiquitously expressed pro-apoptotic tumor suppressor protein. Previously, we have shown that Par-4 undergoes caspase-3 mediated cleavage in normal and cancer cells. In the present study, we demonstrated that caspase-3 generated cleaved fragment of Par-4 displays apoptotic activity. Hela cells were transiently transfected with empty or Myc tagged C-terminal fragment of Par-4. The results from immunofluorescence studies revealed that the cleaved fragment of Par-4 is predominantly localized in the nuclear compartment of the cells. Further, cells expressing C-terminal Par-4 fragment underwent significant apoptosis as compared to empty vector transfected cells as measured by flow cytometry using annexin V/PI staining. Next, we tested whether C-terminal fragment of Par-4 follows similar mechanism of apoptosis induction as the full length Par-4 by the inhibition of protein kinase C (PKC)/NF-κB pathway. Western blot analysis revealed that the overexpression of C-terminal Par-4 fragment reduced the protein levels of Bcl-2 and FLIP as compared to empty vector transfected cells. Overexpression of the C-terminal Par-4 fragment also reduced the levels of phosphorylated IαBβ, however, there was no change in the levels of total IαBβ. Interestingly, C-terminal fragment of Par-4 prevented the nuclear mobilization of NF-κB (p65) compared to empty vector transfected cells. On the other hand, NF-κB (p50) protein levels were found to be decreased in cells expressing the C-terminal Par-4 fragment suggesting that C-terminal fragment of Par-4 possesses pro-apoptotic activity and regulates apoptotic induction by inhibiting the nuclear localization and activity of NF-κB in a manner similar to wild type full length Par-4. To conclude, our data suggest that caspase-3 mediated cleavage of Par-4 results in nuclear localization of C-terminal Par-4 fragment which possesses pro-apoptotic activity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3995. doi:1538-7445.AM2012-3995
The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products
Authors: D.F. Woodward, R.W.C. Carling, C.L. Cornell, H.G. Fliri, J.L. Martos, S.N. Pettit, Y. Liang, J.W. Wang
Journal: Pharmacology & Therapeutics (2008)
CYSTICERCUS CELLULOSÆ OF BRAIN AND SPINAL CORD.
Authors: I. B. DIAMOND
Journal: JAMA (1899)

The relation between the common bladder-worm of the pig, or<i>cysticercus cellulosæ</i>, and the hook-bearing tapeworm that infests the intestines of man, known as tenia solium, was not recognized until 1853, when Küchenmeister first called attention to the resemblance of the bladder-worm head and the head of tenia solium.<sup>1</sup>His observations were soon corroborated, mainly on experimental grounds, by Leuckart,<sup>2</sup>Haubner, Van Beneden and many others<sup>3</sup>—that the eggs of tenia solium, when introduced into the stomach of the pig, by feeding pigs with ripe segments, develop into the familiar bladder-worm (measly pork)—and that the latter is the larval form of the above tenia. Furthermore, the life cycle of this parasite is completed by the metamorphosis of the bladder-worm into the adult tapeworm, when the bladder-worm is taken into the stomach of man and in a few of the lower animals. The knowledge of its life history
Atrioventricular Conduction in Patients with Incomplete Endocardial Cushion Defect
Authors: DANIEL J. GOODMAN, DONALD C. HARRISON, DAVID S. CANNOM
Journal: Circulation (1974)

The cause of left axis deviation noted on the electrocardiogram (ECG) in patients with ostium primum atrial septal defect has been attributed to two differing mechanisms: left ventricular overload secondary to mitral insufficiency and a congenitally anomalous atrioventricular conduction system. In order to define the conduction characteristics of the atrioventricular conduction system in patients free from the hemodynamic abnormalities of ostium primum atrial septal defect, seven patients with an ostium primum atrial septal defect were studied in the late postoperative period. Each ECG showed persisting left axis deviation with no new conduction abnormalities. Hemodynamic evaluation, including left ventriculography, showed no intra-atrial shunting and only minimal mitral insufficiency in three patients. His bundle recording techniques were utilized to study the atrioventricular conduction system. The P-A interval was normal in four patients (25-45 msec) and prolonged in three (50, 60 and 60 msec), while the A-H interval was normal in all seven patients (60-130 msec). This is compatible with abnormal intra-atrial conduction and normal conduction through the atrioventricular node. The H-V interval was normal in four patients (35-55 msec) and short in three (20, 25, and 25 msec). Atrial pacing produced the normally expected A-H prolongation, P-A and H-V remaining constant. These results and the persisting left axis deviation can be explained on the basis of the known anatomy of the atrioventricular conduction system in patients with ostium primum atrial septal defect. The left axis deviation is most probably related to early activation of the postero-basal left ventricular wall (patients with short H-V) and/or late activation of the antero-lateral left ventricular wall (patients with normal H-V). Hemodynamics are not important in producing these findings.
Value of Rectal Biopsy in Paediatric Neurology: Report of 165 Biopsies
Authors: E. M. Brett, C. L. Berry
Journal: BMJ (1967)

One hundred women with incoordinate uterine action had labour managed under continuous epidural analgesia, the average duration of the block being 10 hours.Most of the patients were primigravidae, many were of small stature, and many had large babies, commonly with the occiput in the posterior position.Graphic analysis of labour showed an increased rate of cervical dilatation after epidural block in over 70%.The caesarean section rate remained high (55%) in cases complicated by mechanical dystocia, but where this was not present the caesarean section rate was much lower (14%), while in those patients who had no cephalopelvic disproportion and who showed an increased rate of dilatation after epidural block the caesarean section rate was only 3.8%.With this management, caesarean section is rarely required purely for incoordinate uterine action or maternal distress.The perinatal mortality in the series was 2 %, and there were no serious maternal complications.
On being downstream from faked scientific reports
Authors: Timothy F Murphy
Journal: BMJ (2006)

For some time the US writer David Rorvik held the dubious distinction of being history's greatest hoaxer when it came to human cloning. In the 1970s Rorvik wrote In His Image: The Cloning of a Man , the story of how he helped convene a research team somewhere on a Pacific Ocean island in order to clone a US millionaire (www.museumofhoaxes.com/cloning.html). It wasn't true, of course, but enough people believed this former medical reporter to keep the story afloat. Rorvik was eventually found out, and both author and book faded away, although the idea that people could copy themselves lingered on.

In late 2005 fraud charges starting bubbling around another claimant to success in human cloning. The South Korean researcher Hwang Woo-Suk and colleagues had reported earlier that year that they had used cloning techniques to create stem cell lines of 11 people. The report followed up a 2004 report indicating success in using nuclear transfer techniques to produce an early stage human embryo. Both reports appeared in one of the most eminent scientific journals in the world, Science . Even so, it was not long before critics began to call the findings into question, and a hastily convened review panel found that—contrary to the …
Does Bad News about Suicide Beget Bad News?
Authors: Leon Eisenberg
Journal: New England Journal of Medicine (1986)

Among American adolescents between 15 and 19 years of age, suicide is the second most important cause of death, resulting in almost 1700 lives lost each year. In 1983, the latest year for which national data are available, the mortality rate from suicide among males in this age group (14.0 per 100,000) was second only to that from accidents; the much lower mortality rate from suicide among female adolescents (3.2 per 100,000) was surpassed by the rates from accidents, homicides, and cancer (National Center for Health Statistics: unpublished data). Between 1950 and 1977, the suicide rates for 15-to-19-year-olds rose precipitously: . . .
Reversible bilateral ureteric obstruction due to a pancreatic pseudocyst.
Authors: G E Gibson, E Tiernan, C C Cronin, J B Ferriss
Journal: Gut (1993)

An unusual case of bilateral ureteric obstruction and hydronephrosis due to pancreatic pseudocyst formation, after an episode of acute pancreatitis is reported. All abnormalities resolved with conservative management. Possible reasons for such ureteric obstruction include periureteric fat necrosis by pancreatic enzymes and compression by the inflammatory mass.
An Evaluation of the Hazard Created by Natural Death at the Wheel
Authors: Susan P. Baker, Werner U. Spitz
Journal: New England Journal of Medicine (1970)

Abstract Assessment of the hazard associated with sudden natural death of drivers suggests that the magnitude of the problem does not warrant costly and restrictive control efforts. Investigation of 591 collisions that caused fatal injuries to drivers or pedestrians revealed that none of them resulted from natural death at the wheel. Natural death of a sober driver apparently does not entail measurable risk of death or severe injury to his passengers or other persons. Collisions caused by these deaths are relatively infrequent, representing less than 6 per 10,000 motor-vehicle collisions. Nonfatal medical impairments still need to be explored more precisely before driver examinations and restrictions can be considered justified and effective.
Abnormal Forearm Vascular Responses During Dynamic Leg Exercise in Patients With Vasovagal Syncope
Authors: Helen L. Thomson, Suhas S. Lele, John J. Atherton, Karen N. Wright, Wayne Stafford, Michael P. Frenneaux
Journal: Circulation (1995)

Background We have reported previously that in some patients with normal hearts who present with exercise syncope, abnormal forearm vasodilation is seen during leg exercise and tilt table tests are positive. This suggests that exercise syncope may be a variant of vasovagal syncope. In this study we tested the hypothesis that there is loss of the normal forearm vasoconstrictor response during dynamic leg exercise in an unselected population of patients with classic vasovagal syncope. Methods and Results We evaluated forearm vascular responses during maximal semierect cycle exercise in 28 consecutive patients with vasovagal syncope and compared them with 30 age-matched control subjects. We also evaluated blood pressure responses during erect treadmill exercise (Bruce protocol). While forearm vascular resistance at rest was similar in the patients with vasovagal syncope and the control group, forearm vascular resistance was markedly lower in the patients than in control subjects at peak exercise (85±54 versus 149±94 units, P =.002). Forearm vascular resistance fell by 3±48% during exercise in patients versus an increase of 135±103% in control subjects ( P &lt;.0001). Systolic blood pressure during erect exercise was lower in patients versus control subjects (155±32 versus 188±17 mm Hg, P &lt;.0001). Six of the vasovagal patients complained of exercise syncope or presyncope on specific inquiry, and 4 of these 6 exhibited exercise hypotension during erect treadmill exercise testing. Conclusions Patients with vasovagal syncope exhibit a failure of the normal vasoconstrictor response in the forearm during dynamic leg exercise. Exercise syncope and presyncope are not uncommon in unselected patients with classic vasovagal syncope, as is exercise hypotension.