tbuckley/cabot-search huggingface dataset:
&lt;emph type="ital"&gt;Abraham Lincoln and Stephen A. Douglas—Debate at Charleston, Illinois, September 18, 1858&lt;/emph&gt;
Authors: Thomas B. Cole
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paying for bmj.com: Let the journal be innovative in maintaining information flows and linkages
Authors: A. Midgley
Journal: BMJ (2003)

Editor—Responses to the move of paying for bmj.com have focused on cost and value.1,2 I, however, regret this move for its effect on the usability of the medical web.

The closer we get to a seamless flow of information, and the connections and transitions between items of information, the better. But much of the medical web is isolated in little bubbles with an access barrier to be negotiated, and much is not indexed by the search engines.

The journals hosted on the Highwire servers are already in a bubble for search engines for realistic reasons, but it is a pity that the BMJ's content is about to retreat deeper into the foam we all struggle through.

Authentication and the need for collecting money impair the function characteristic of the web—linkage between items of information—thereby reducing the usability and usage of the system as a whole. However, the move proposed seems to be the emerging consensus in newspaper publishing.

If we have to have a charging system to maintain profits, so be it. But can the journal that was innovative in open medical web publishing ensure that it is innovative in maintaining the flow and connections despite its payments, please?
UK consultation rejects restriction of impotence treatment funding
Authors: M. Pownall
Journal: BMJ (1999)

The UK Department of Health has received more than 800 comments-largely hostile-on its proposals to limit funding for the treatment of erectile dysfunction to a few specific conditions, during a consultation period on the proposals, which ended last week.

Comments received during the consultation period included opposition from medical and patient organisations, as well as from individual doctors and patients. An official from the Department of Health said that the scale of the …
Role of adenosine and its interaction with adrenoceptor activity in ischaemic and reperfusion injury of the myocardium
Authors: M. Kitakaze, M. Hori, T. Kamada
Journal: Cardiovascular Research (1993)

Adenosine is recognised as an important regulator of myocardial function and coronary vascular tone in the ischaemic myocardium. It is produced by the enzymatic dephosphorylation of 5'-AMP by 5'-nucleotidase and the hydrolysis of SAH by SAH-hydrolase. 5'-Nucleotidase is thought to contribute to adenosine production aside from the accumulation of 5'-AMP in the ischaemic myocardium, while the hydrolysis of SAH plays a major role in adenosine production in the normoxic myocardium. 5'-Nucleotidase activity is reported to increase adenosine production through accumulation of ATP, ADP, H+, Mg2+ and inorganic phosphate during ischaemia. In addition, we have found that alpha 1 adrenergic receptors, activated in ischaemic hearts, increase both 5'-nucleotidase activity and adenosine production. Inactivation of adenosine deaminase and adenosine kinase may also contribute to adenosine production. On the other hand, the major role of endogenous adenosine is to increase coronary blood flow. This adenosine induced coronary vasodilatation is amplified by alpha 2 adrenoceptor stimulation. Adenosine induced vasodilatation is also enhanced by increasing H+ and opening ATP sensitive K+ channels, which occurs in the ischaemic myocardium. However, coronary vasodilatation is not the only effect of adenosine in the ischaemic myocardium. Stimulation of adenosine A2 receptors coupled to Gs proteins attenuates both free radical generation by activated leucocytes and aggregation of platelets. Adenosine A1 receptor activation coupled to G(i) proteins attenuates beta adrenoceptor mediated increases in myocardial contractility, Ca2+ influx into myocytes, and noradrenaline release from the presynaptic nerves. Any or all of these effects may attenuate ischaemic and reperfusion injury.(ABSTRACT TRUNCATED AT 250 WORDS)
Human versus mouse eosinophils: “That which we call an eosinophil, by any other name would stain as red”
Authors: James J. Lee, Elizabeth A. Jacobsen, Sergei I. Ochkur, Michael P. McGarry, Rachel M. Condjella, Alfred D. Doyle, Huijun Luo, Katie R. Zellner, Cheryl A. Protheroe, Lian Willetts, William E. LeSuer, Dana C. Colbert, Richard A. Helmers, Paige Lacy, Redwan Moqbel, Nancy A. Lee
Journal: Journal of Allergy and Clinical Immunology (2012)
REMARKS ON THE AFTER-EFFECTS OF OPERATIONS FOR THE REMOVAL OF ADENOID TISSUE AT THE VAULT OF THE PHARYNX.
Authors: E. L. SHURLY
Journal: JAMA (1901)

In view of the great frequency of operations for the removal of adenoids from the nasopharynx, it is a little surprising that serious accidents or sequences are not more often heard of. For this reason it might seem superfluous to the philosopher for any one to attempt the awakening of apprehension over so simple and safe a surgical procedure as this one; still, it is not by any means entirely devoid of grave complications. Having met with a few cases where the operation was followed by troublesome results, it will not be amiss to bring the subject before the Section for discussion. <h3>Classification.</h3> —For convenience of consideration, cases of adenoids or lymphoid hypertrophy at the vault of the pharynx may be classified as: simple, or those cases presenting enlargement or overgrowth of the lymphoid tissue at the vault of the pharynx only; and, complex, or those cases in which the
Educating Doctors: Crisis in Medical Education, Research and Practice
Authors: Andrew D. Hunt
Journal: JAMA (1997)

Medical Education  Dr Wolf's book opens with a critique of  current status of medical education at both college and medical school levels. He deplores  emphasis on scientific fact in college at  expense of liberal education in  arts and humanities. He feels that admission to medical school is based solely on mastery of scientific fact and that  total immersion in basic science continues through  4 years. At  clinical level, bedside teaching has largely been replaced by impersonal exercises such as chart rounds, and  skilled physician-teacher is rarely observed talking to patients and taking a proper history with appropriate consideration of social and behavioral influences. The result is that  student learns to take histories in a rote, mechanical, question-and-answer mode.  the fallacy of  distinction between organic and functional illness  This reviewer agrees with Wolf's critique of medical education up to a
Abstract A24: CpG island methylation of microRNAs is associated with tumor size and the recurrence of non-small cell lung cancer
Authors: Kentaro Kitano, Akiteru Goto, Masashi Fukayama, Yutaka Yatomi, Nobuya Ohishi, Daiya Takai, Kousuke Watanabe, Noriko Emoto, Hidenori Kage, Emi Hamano, Takahide Nagase, Atsushi Sano, Tomohiro Murakawa, Jun Nakajima
Journal: Clinical Cancer Research (2012)

Abstract We investigated whether the CpG island methylation of certain microRNAs was associated with the clinicopathological features and the prognosis of non-small cell lung cancer. The methylation of mir-152, -9-3, -124-1, -124-2, and -124-3 was analyzed in 96 non-small cell lung cancer specimens using a combined bisulfite restriction analysis. The median observation period was 49.5 months. The methylation of mir-9-3, -124-2, and -124-3 was individually associated with an advanced T factor independently of age, sex, and smoking habit. Moreover, the methylation of multiple microRNA loci was associated with a poorer progression-free survival in a univariate analysis. Our result enlightens the accumulation of aberrant DNA methylation which occurs in concordance with the tumor progression.
Tissue Engineering of a Differentiated Cardiac Muscle Construct
Authors: W.-H. Zimmermann, K. Schneiderbanger, P. Schubert, M. Didié, F. Münzel, J.F. Heubach, S. Kostin, W.L. Neuhuber, T. Eschenhagen
Journal: Circulation Research (2002)

Cardiac tissue engineering is an emerging field. The suitability of engineered heart tissue (EHT) for both in vitro and in vivo applications will depend on the degree of syncytoid tissue formation and cardiac myocyte differentiation in vitro, contractile function, and electrophysiological properties. Here, we demonstrate that cardiac myocytes from neonatal rats, when mixed with collagen I and matrix factors, cast in circular molds, and subjected to phasic mechanical stretch, reconstitute ring-shaped EHTs that display important hallmarks of differentiated myocardium. Comparative histological analysis of EHTs with native heart tissue from newborn, 6-day-old, and adult rats revealed that cardiac cells in EHTs reconstitute intensively interconnected, longitudinally oriented, cardiac muscle bundles with morphological features resembling adult rather than immature native tissue. Confocal and electron microscopy demonstrated characteristic features of native differentiated myocardium; some of these features are absent in myocytes from newborn rats: (1) highly organized sarcomeres in registry; (2) adherens junctions, gap junctions, and desmosomes; (3) a well-developed T-tubular system and dyad formation with the sarcoplasmic reticulum; and (4) a basement membrane surrounding cardiac myocytes. Accordingly, EHTs displayed contractile characteristics of native myocardium with a high ratio of twitch (0.4 to 0.8 mN) to resting tension (0.1 to 0.3 mN) and a strong β-adrenergic inotropic response. Action potential recordings demonstrated stable resting membrane potentials of −66 to −78 mV, fast upstroke kinetics, and a prominent plateau phase. The data indicate that EHTs represent highly differentiated cardiac tissue constructs, making EHTs a promising material for in vitro studies of cardiac function and tissue replacement therapy.
1187 PNPLA3 SEQUENCE VARIANT (RS738409) CONFERS SUSCEPTIBILITY TO LIVER DAMAGE AND CIRRHOSIS IN HCV RELATED LIVER DISEASE
Authors: M. Thursz, S.G. Corradini, P. Toniutto, A. Molinaro, L. Palla, S. Knapp, Q. Anstee, I. Huang-Doran, R. Goldin, S. Romeo
Journal: Journal of Hepatology (2011)
Heart Disease: A Textbook of Cardiovascular Medicine
Authors: Samuel Zoneraich
Journal: JAMA (1997)

This is a magnificent and vast opus with 21 new chapters and approximately 2000 pages, 450 tables, 4000 illustrations, and 18000 references. Masterfully, it reflects the state of the art of contemporary cardiology. The text has five parts, subdivided to deal with the history and physical examination, noninvasive and invasive techniques, pathophysiology, diagnosis and treatment, congenital and acquired diseases in adults and children, genetics, the aging heart, postoperative cardiac care, economics, and, finally, the relationship between diseases of other organs and the cardiovascular system. In fact, Braunwald's text is a brilliant continuation of Friedberg's text of the 1950s and 1960s. Modern technology, excellent production, and especially the contributions of so many experts have raised Braunwald's fifth edition to rarely achieved heights. In his impressive inaugural chapter on the history, Braunwald conveys that listening to the patient is essential for gaining trust and understanding the patient's illness. History taking remains a
Die hypnotische Person
Authors: Ernst Schneider
Journal: Psychotherapy and Psychosomatics (1956)

Research Articles| February 10 2010 Die hypnotische Person Subject Area: Psychiatry and Psychology Ernst Schneider Ernst Schneider Basel Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1956) 4 (4): 325–329. https://doi.org/10.1159/000285259 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ernst Schneider; Die hypnotische Person. Acta Psychotherapeutica et Psychosomatica 1 April 1956; 4 (4): 325–329. https://doi.org/10.1159/000285259 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1956Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Suggestion for a Committee to Pass on New Medical Books
Authors: G. Wilds Linn
Journal: JAMA (1913)

<h3>To the Editor:</h3> —May I suggest for the consideration of the American Medical Association at its coming meeting the desirability of appointing a committee for the purpose of passing on the intrinsic merits of medical publications placed on the market? Publishing houses are financially interested in their output, and reviews are too often written hastily and sometimes perhaps with a personal bias; while no single reviewer associated with any periodical can be expected to possess such encyclopedic knowledge as is necessary in a field so varied and extensive. For these reasons thousands of physicians, and especially those far removed from publishing centers, are quite unable to decide what books may be most worthy of their attention. An advisory or reviewing committee (like the Council on Pharmacy and Chemistry) of capable physicians, appointed by the Association because of their technical and practical knowledge of the various specialties and whose members
Upper Gastrointestinal Hemorrhage Associated with Fistula Formation in the Duodenum due to a Catheter Placed in the Hepatic Artery
Authors: M. Muñoz-Navas, J. Jimenez-Perez, J. Sagues, J. Zozaya
Journal: Endoscopy (1987)

Various fistulous complications have been described in the gastrointestinal tract associated with the presence of a prosthesis or catheters located in the aorta or in other great abdominal arteries, either to resolve aneurysms or to bypass occlusive diseases. Exceptionally, enteric fistulas associated with a surgically implanted arterial chemotherapy infusion catheter in the hepatic artery may also occur, as has been previously demonstrated (2, 3).
Notes on a Case of Acute Yellow Atrophy of the Liver
Authors: G. H. Pearce
Journal: BMJ (1900)

LIVER.[ , o 1371 or sigmoid gut can be made to reach the caecum except by the aid of very violent massage.Co-existence of Enterie Fever and Dysentery.-Theco-exist- ence of enteric fever with dysentery was more than once unexpectedly disclosed in our mortuary tent, and I am per- mitted to state that the medical returns of the hospital will show how very often the two diseases occur, if not simultane- ously, within a short interval of one another.When co- existent the cardinal symptoms of either are certainly much modified, and it is in these cases especially that Widal's react'on has been of the greatest service to us.
Coal hydrogenation and environmental health.
Authors: R A Wadden
Journal: Environmental Health Perspectives (1976)

Planning of coal hydrogenation processes, such as liquifaction and gasification, requires consideration of public health implications. Commercial plants will require coal quantities greater than or equal to 20,000 tons/day and the large size of these plants calls for careful consideration of the potential health hazards from the wastes and products of such processes. Analysis of pollution potential can roughly be divided into three categories: raw material structure and constituents, process design, and mode of plant operation. Identifiable pollutants include hydrogen cyanide, phenols, cresols, carbonyl and hydrogen sulfides, ammonia, mercaptans, thiocyanides, aniline, arsenic, trace metals and various polycyclic hydrocarbons. One study of workers in a hydrogenation process has revealed an incidence of skin cancer 16-37 times that expected in the chemical industry. In addition, a number of high boiling point liquid products were identified as being carcinogenic, and air concentrations of benzo[a]pyrene up to 18,000 mug/1000 m3 were reported. Health statistics on occupational groups in other coal conversion industries have shown significantly higher lung cancer rates, relative to groups without such occupational exposures. These data suggest that coal hydrogenation plants must be carefully planned and controlled to avoid harm to environmentally and occupationally exposed populations.
Breast Uptake of Technetium-99m MDP During Radionuclide Angiography
Authors: SEYDI AKSUT, RAMI GAL, STEVEN PORT
Journal: Clinical Nuclear Medicine (1990)

A 31-year-old woman who developed congestive heart failure during her first pregnancy was scheduled for a resting, gated cardiac blood pool scan two weeks after delivery. She had not breast-fed her infant. High-quality RBC tagging was obtained, together with in vivo labeling and Tc-99m MDP. In this case, intense breast uptake of the radionuclide was seen, which confirms reports of uptake of Tc-99m and its excretion in breast milk and breast tissue in mothers given bone imaging agents.
The predominant myeloma clone at diagnosis, CDR3 defined, is constantly detectable across all stages of disease evolution
Authors: N Puig, I Conde, C Jiménez, M E Sarasquete, A Balanzategui, M Alcoceba, J Quintero, M C Chillón, E Sebastián, R Corral, L Marín, N C Gutiérrez, M-V Mateos, M González-Díaz, J F San-Miguel, R García-Sanz
Journal: Leukemia (2015)
The Advantages of Ether as an Anaesthetic: with a Description of a New Inhaler
Authors: L. H. Ormsby
Journal: BMJ (1877)

45'prominent, necessitating its being divided on the riglht side and pressed down into its place.The steps and mode of operation were similar to those in the preceding one.In this case, I feared that the immediate effects of the operation, and the interference with the infant's limited supply of breast-milk, might jeopardise its recovery ; but I was care- ful to direct that all the milk drawn from the mother should be given to the child.The result was happily very satisfactory, for on the sixth day the infant was able to suck.It now sucks perfectly, and is thriving well.The cleft in the palate, I am able to state, is quite closed, no doubt by the continuious pressure of the unite(d lip.The first case adds one more to the few recorded instances of newly born infants successfully operated upon for hare-lip.The second shows that, within a few days after operation, an infant is capable of sucking.Indeed, the good re.ults attending these two cases have encouraged me to bring the question of early operation before the profession.
MIGRATION OF LYMPHOCYTES AND THYMOCYTES IN THE RAT
Authors: Irving Goldschneider, Douglas D. McGregor
Journal: The Journal of Experimental Medicine (1968)

The cellular deficit in rats thymectomized at birth is primarily one of circulating small lymphocytes. The lymphocyte deficiency is similar to that induced in adult rats by chronic drainage from a thoracic duct fistula. In both cases, the animals show a reduction of small lymphocytes in peripheral blood, thoracic duct lymph, and in circumscribed areas of lymphoid tissue. The lympocyte deficiency in lymphoid tissue can be corrected by an intravenous injection of thoracic duct lymphocytes. The evidence suggests that the deficiency is corrected by small lymphocytes. Small lymphocytes pass from blood to lymphoid tissue along a route which includes the marginal sinus in splenic white pulp and postcapillary venules in the cortex of lymph nodes and Peyer's patches. Neither the ability of small lymphocytes to colonize lymphoid tissue nor their ability to traverse postcapillary venules are thymus-dependent phenomena. However, movement of small lymphocytes across postcapillary venules appears to modify the structure of endothelium. Intravenously injected small thymocytes migrate to lymphoid tissue in smaller numbers than small lymphocytes inoculated by the same route. The few thymocytes which localize in lymphoid tissue follow the same pathway as circulating small lymphocytes.
A Man in His 50s With a Giant Abdominal Mass
Authors: Vakhtang Tchantchaleishvili, Randeep Kashyap, Mark S. Orloff
Journal: JAMA Surgery (2015)

Aman in his 50swhopreviously underwent renal transplantation for polycystic kidney disease presented with worsening chronic malaise, fatigue, dyspnea, early satiety, and abdominal distention with extreme discomfort. An abdominalmagnetic resonance image is shown inFigure1A.Giventhesymptomsandmagnetic resonance imagingfindings, the patient was eventually taken to the operating room. Laparotomy exposed a giant multinodular mass (Figure 1B). A B