Superantigens and Microbial Pathogenesis
Authors: Dennis D. Taub
Journal: Annals of Internal Medicine (1993)

Editorials1 July 1993Superantigens and Microbial PathogenesisDennis D. Taub, PhD and Kenneth J. Blank, PhDDennis D. Taub, PhDNational Cancer Institute, Frederick, MD 21702. Hahnemann University, Philadelphia, PA 19102.Search for more papers by this author and Kenneth J. Blank, PhDNational Cancer Institute, Frederick, MD 21702. Hahnemann University, Philadelphia, PA 19102.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-1-199307010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The results of a randomized, controlled trial of endoscopic ligation of esophageal varices compared with sclerotherapy by Laine and colleagues, in this issue of Annals, is the second report of a relatively new endoscopic technique. The two techniques appear to be approximately comparable, except that the complication rate is less with ligation. Whether ligation will replace sclerotherapy remains to be seen.Recent analysis of various bacterial and viral products has revealed that microbial proteins may be not only responsible for microbial infection and disease but also connected to the onset of autoimmunity. These microbial products are called superantigens because of ...References1. Marrack P, Kappler J. The staphylococcal enterotoxins and their relatives. Science. 1990; 248:705-11. Google Scholar2. Herman A, Kappler JW, Marrack P, Pullen AM. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu Rev Immunol. 1991; 9:745-72. Google Scholar3. Allison JP, Lanier LL. Structure, function, and serology of the T-cell antigen receptor complex. Ann Rev Immunol. 1987; 5:503-40. Google Scholar4. Janeway CA Jr, Yagi J, Conrad PJ, Katz ME, Jones B, Vroegop S, et al. T-cell responses to Mls and to bacterial proteins that mimic its behavior. Immunol Rev. 1989; 107:61-88. Google Scholar5. 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Protection from experimental allergic encephalomyelitis by application of a bacterial superantigen. Int Immunol. 1992; 4:347-53. Google Scholar Author, Article, and Disclosure InformationAuthors: Dennis D. Taub, PhD; Kenneth J. Blank, PhDAffiliations: National Cancer Institute, Frederick, MD 21702. Hahnemann University, Philadelphia, PA 19102.Corresponding Author: Kenneth J. Blank, MD, Hahneman University, Department of Pathology, MS435, Room 5409, Broad and Vine, Philadelphia, PA 19102. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDETERMINANTS THAT MAY BE INVOLVED IN VIRULENCE AND DISEASE IN Campylobacter jejuniMetabolism and Biology of TryptophanLipopolysaccharide is required for the lethal effects of enterotoxin B after D-galactosamine sensitizationMultifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy 1 July 1993Volume 119, Issue 1Page: 89-90KeywordsAntigensBacterial diseasesEnterotoxinsPathogenesisPopulation statisticsProteinsT cell receptorsT cellsToxic shock syndromeToxins ePublished: 15 August 2000 Issue Published: 1 July 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...