tbuckley/cabot-search huggingface dataset:
The PROTECT in‐hospital risk model: 7‐day outcome in patients hospitalized with acute heart failure and renal dysfunction
Authors: Christopher M. O'Connor, Robert J. Mentz, Gad Cotter, Marco Metra, John G. Cleland, Beth A. Davison, Michael M. Givertz, George A. Mansoor, Piotr Ponikowski, John R. Teerlink, Adriaan A. Voors, Mona Fiuzat, Daniel Wojdyla, Karen Chiswell, Barry M. Massie
Journal: European Journal of Heart Failure (2012)
CCL2, Galectin-3, and SMRP Combination Improves the Diagnosis of Mesothelioma in Pleural Effusions
Authors: Christophe Blanquart, Fabien Gueugnon, Jean-Michel Nguyen, David Roulois, Laurent Cellerin, Christine Sagan, Christian Perigaud, Arnaud Scherpereel, Marc Gregoire
Journal: Journal of Thoracic Oncology (2012)
Trypsin-like Immunoreactivity as a Test for Pancreatic Insufficiency
Authors: Dan G. Jacobson, Cheryl Curington, Kathleen Connery, Phillip P. Toskes
Journal: New England Journal of Medicine (1984)

AT present, the clinician has several tests available for the assessment of pancreatic function. However, many of these tests lack sensitivity or specificity or both, or are difficult to perform. Recently, an enzymatic assay kit for trypsin-like immunoreactivity has been made available. This kit, called the Trypsik kit, assays for cathodic trypsinogen, a zymogen synthesized only by the pancreas. A depressed serum level of trypsin-like immunoreactivity has been reported in patients with alcohol-induced chronic pancreatitis1 and cystic fibrosis.2 The objectives of this study were to evaluate the sensitivity and specificity of a decreased serum level of trypsin-like immunoreactivity as a . . .
The shift in the myocardial adenine nucleotide translocator isoform expression pattern is associated with an enteroviral infection in the absence of an active T-cell dependent immune response in human inflammatory heart disease
Authors: Andrea Dörner, Mathias Pauschinger, Peter L Schwimmbeck, Uwe Kühl, Heinz-Peter Schultheiss
Journal: Journal of the American College of Cardiology (2000)
The Western Blot
Authors: Rafel D. Rieves
Journal: Annals of Internal Medicine (1996)

Ad Libitum15 August 1996The Western BlotRafel D. Rieves, MDRafel D. Rieves, MDWashington, DC 20009Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-4-199608150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Like February crows,darting horizon to treea twitching branch or yapping dogshould scatter our flockNot the odd absenceHow this happened and whyhawk-eyed aunts and limp-jawedneighbors whisperin aching tonesfelt more than heardAmber sunsets, strongand solidshe knew, as we all knowYet, with this touchour coveysqueaks and cawsthe stuttering chatter to splintera chilled evening's crystal calm“City birds,” one says“are different, slovenly loosefume-choked and brashsuch things are commonnot here”Something's wrongso young, so prettya farming town's pridebut here?A city-savvy virus wrinklesa stealthy smileTogether we perch, again to touchnurturing proper and dyingrightYet in the crisp ... Author, Article, and Disclosure InformationAffiliations: Washington, DC 20009Corresponding Author: Rafel D. Rieves, MD, 1907 New Hampshire Avenue, NW, Washington, DC 20009. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1996Volume 125, Issue 4Page: 343KeywordsTouchWestern blot ePublished: 15 August 2000 Issue Published: 15 August 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Trends in Smoking Initiation Among Adolescents and Young Adults—United States, 1980-1989
Authors: K M Cummings, D Shah
Journal: JAMA (1995)

The evaluation of efforts to prevent tobacco use among adolescents requires accurate surveillance of both smoking prevalence and smoking initiation rates. Although several surveillance systems provide timely data about adolescent smoking prevalence (1), data characterizing rates of smoking initiation among adolescents have been limited. To improve characterization of trends in smoking initiation among young persons, data from the Tobacco Use Supplement of the 1992 and 1993 Current Population Surveys (CPS) (2) were used to estimate smoking initiation rates for persons who were adolescents (aged 14-17 years) or young adults (aged 18-21 years) during 1980-1989. This report summarizes the results of that analysis.
Thrombogenic Materials in Prothrombin Complex Concentrates
Authors: PHILIP M. BLATT
Journal: Annals of Internal Medicine (1974)

Prothrombin complex concentrates are now available for use for treatment of bleeding complications associated with deficiencies of factors II, VII, IX, or X. The purpose of this report is to describe a patient who died immediately after the infusion of such a concentrate. Postmortem studies showed that the cause of death was diffuse thromboembolism. Laboratory studies on the concentrate were done after the patient's death and revealed the presence of "clot-accelerating factors." Their presence suggests that the infused material was thrombogenic. In view of the potential hazards associated with these concentrates, guidelines are suggested for their continued use.
Abstract C30: Resistance to fluid shear stress is a conserved biophysical property of malignant cells
Authors: James Matthew Barnes, Jones T. Nauseef, Michael D. Henry
Journal: Cancer Research (2013)

Abstract During metastasis, cancer cells enter the circulation in order to gain access to distant tissues, but how this fluid microenvironment influences cancer cell biology is poorly understood. A longstanding view is that circulating cancer cells derived from solid tissues may be susceptible to damage from hemodynamic shear forces, contributing to metastatic inefficiency. However, there have been few efforts to directly test this hypothesis. Here we report that compared to non-transformed epithelial cells, transformed cells are remarkably resistant to fluid shear stress (FSS) in a microfluidic protocol, exhibiting a biphasic decrease in viability when subjected to a series of millisecond pulses of high (750-6,300 dyn/cm2) FSS. We show that magnitude of FSS resistance is influenced by several oncogenes including myc, ras, and PI3K; is an adaptive and transient response triggered by reparable plasma membrane damage; and requires extracellular calcium and actin cytoskeletal dynamics, including the activity of Rho kinase. This novel property of malignant cancer cells may facilitate hematogenous metastasis and indicates, contrary to expectations, that cancer cells are quite resistant to destruction by hemodynamic shear forces. Citation Format: James Matthew Barnes, Jones T. Nauseef, Michael D. Henry. Resistance to fluid shear stress is a conserved biophysical property of malignant cells. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr C30.
Low level of HBV-DNA is the most powerful predictive factor of better response to IFN-α therapy in chronic hepatitis B
Authors: K. Simon, A. Gładysz, M. Zalewska, K. Rotter, W. Dobracki, A. Głowacki, M. Inglot, B. Knysz, A. Machaj, P. Piszko
Journal: Journal of Hepatology (1998)
Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor.
Authors: G C Howard, U K Misra, D L DeCamp, S V Pizzo
Journal: Journal of Clinical Investigation (1996)

Receptor-recognized forms of alpha 2-macroglobulin (alpha 2M*) bind to two macrophage receptors: an endocytic receptor, the low density lipoprotein receptor-related protein/alpha 2M receptor (LRP/alpha 2MR), and a G protein-coupled receptor, the alpha 2M signaling receptor (alpha 2MSR). Binding of alpha 2M* to LRP/alpha 2MR but not alpha 2MSR is inhibited by receptor-associated protein. We now present binding characteristics of alpha 2MSR (kD approximately 50 pm; 1,530 sites/cell) using Scatchard analysis. We also demonstrate that chemical modification of alpha 2M* with cis-dichlorodiammineplatinum (cis-DDP) does not significantly alter binding to either receptor or signaling characteristics as compared with unmodified alpha 2M*. However, internalization by LRP/alpha 2MR is greatly affected. Cis-DDP-modified alpha 2M* (cis-DDP-alpha 2M*) and alpha 2M* show comparable internalization during a single round of endocytosis; however, cis-DDP modification of alpha 2M* results in a > or = 82% reduction in internalization involving receptor recycling and multiple rounds of endocytosis. Results from pH 5.0 dissociation and receptor recycling experiments suggest that the mechanism of decreased internalization of cis-DDP-alpha 2M* involves poor dissociation from the receptor in endosomes and a decrease in available surface receptors over the time of exposure to the ligand.
[490] GENOTYPE A2 INFLUENCE UPON THE RESPONSE TO ADEFOVIR DIPIVOXIL TREATMENT
Authors: N. Chueca, C. Nogales, A. Gila, E. Suarez, B. Puche, B. Figueruela, A. Pea, M. Romero, I. Martin, R. Daza, R. Andrade, S. Lopez, P. Muoz de Rueda, F. Garcia, J. Salmeron
Journal: Journal of Hepatology (2007)
Response to Inhaled Nitric Oxide in Acute Lung Injury Depends on Distribution of Pulmonary Blood Flow Prior to Its Administration
Authors: RENÉ GUST, TIMOTHY J. McCARTHY, JAMES KOZLOWSKI, ALAN H. STEPHENSON, DANIEL P. SCHUSTER
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Responses to inhaled nitric oxide (iNO) in acute lung injury (ALI), as evidenced by improvements in oxygenation, are variable. We hypothesized that the effect of iNO may be related to the pre-iNO distribution of pulmonary blood flow (PBF). In the present study we evaluated the effect of iNO on PBF in normal healthy dogs and in a canine model of ALI induced by oleic acid (OA). In Group "OA only" (n = 5), ALI was induced by central venous injection of 0.08 ml/kg OA. In Group "E + OA" (n = 5), hypoxic pulmonary vasoconstriction after ALI was blocked with low-dose endotoxin (15 μ g/kg of Escherichia coli endotoxin) administered 30 min before giving the same dose of OA. Measurements of regional PBF and lung water concentration (LWC) using positron emission tomography (PET) and H2 15O were performed before and after OA or placebo, and then again at concentrations of 10, 40, and 0 ppm iNO. One hundred twenty minutes after OA injury, PaO2 /Fi O2 fell significantly in Group OA only, from 567 ± 32 to 437 ± 67 mm Hg. In these animals, PBF redistributed from the dorsal edematous regions of the lungs to the nondependent zones, thus partially preserving normal ventilation/ perfusion relationships. As in the normal animals, in Group OA only, iNO did not significantly change either PBF or oxygenation. In Group E + OA, the administration of low-dose endotoxin eliminated perfusion redistribution from the dorsal edematous lung regions. As a result, PaO2 /Fi O2 fell from 558 ± 70 to 119 ± 53 mm Hg, a decrease that was significantly greater than that in Group OA only. In Group E + OA, administration of iNO restored perfusion redistribution to a similar level as in Group OA only, which was associated with a significant improvement in PaO2 /Fi O2 , from 119 ± 53 to 251 ± 159 (10 ppm iNO), and 259 ± 165 mm Hg (40 ppm iNO). We conclude that the effect of iNO on oxygenation after ALI depends on the pre-iNO perfusion pattern, which may help explain the variable response to iNO often observed in patients with acute respiratory distress syndrome.
Gene defects and allergy
Authors: H. V. Bever, B. Lane, J. Common
Journal: BMJ (2009)

Identifying specific genotypes of allergy is a major breakthrough in patient care

Allergic diseases—such as asthma, rhinitis, and eczema—have been increasing worldwide over several decades, and the increase has largely been attributed to a Western lifestyle (the hygiene hypothesis). However, the exact causes of the increase are unknown. Several trigger mechanisms are probably involved, but it is still not clear whether similar triggers are responsible for the increases seen in different allergic diseases.1 In the linked systematic review (doi: 10.1136/bmj.b2433), van den Oord and Sheikh assess the association between defects of the filaggrin gene ( FLG ) and the risk of developing allergic sensitisation and allergic disorders.2 

Allergies form a heterogeneous group of diseases in which IgE mediated reactions are the key feature, and a wide variety of symptoms can occur. Diagnosis is largely based on the history, symptoms, and detection of IgE …
DOMESTIC CORRESPONDENCE.
Authors: John M. Batten
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Simultaneous coronary bypass and carotid endarterectomy advocated
Authors: W. Check
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Postmenopausal Hormones, Alcohol, and Risk for Invasive Breast Cancer
Authors: Wendy Y. Chen
Journal: Annals of Internal Medicine (2002)

Background: Physiologic evidence suggests that use of alcohol increases the risk for breast cancer through a hormonal mechanism, but the relationship among breast cancer, alcohol, and postmenopausal hormones (PMH) remains unclear. Objective: To examine the relation between concurrent use of alcohol and PMH and invasive breast cancer. Design: Prospective cohort study Setting: Nurses' Health Study. Participants: 44 187 postmenopausal women. Measurements: Self-reported data on PMH use and breast cancer obtained from biennial questionnaires completed from 1980 to 1994 and average alcohol consumption in 1980, 1984, 1986, and 1990. Results: 1722 women developed invasive breast cancer. Risk for breast cancer was elevated in women who currently used PMH for 5 or more years and did not drink alcohol (relative risk, 1.32 [95% CI, 1.05 to 1.66]) and those who never used PMH but drank 20 or more g (1.5 to 2 drinks) of alcohol daily (relative risk, 1.28 [CI, 0.97 to 1.69]). Current users of PMH for 5 or more years who consumed 20 or more g of alcohol daily had a relative risk for breast cancer nearly twice (1.99 [CI, 1.42 to 2.79]) that of nondrinking nonusers of PMH. A hypothetical postmenopausal woman whose lifetime risk for breast cancer is 4% could increase her risk to 8% with 5 or more years of current PMH use and consumption of more than one alcoholic drink daily. Conclusions: Both alcohol consumption and PMH use were associated with an increased incidence of breast cancer. Women who are currently taking PMH may want to consider the added risks of regular alcohol consumption.
Abstract LB-113: Genome-wide mapping of TFE3-fusion target genes.
Authors: Ying Huang, Masaya Baba, Hisashi Hasumi, Yukiko Hasumi, Laura Schmidt, Yoshi Wakabayashi, Jun Zhu, Wenjing Yang, Marston Linehan
Journal: Cancer Research (2013)

Abstract Xp11.2 translocation renal cell carcinoma (RCC), also known as TFE3-fusion associated RCC, is a recently classified distinct subtype of RCC. It is defined by several different translocations involving chromosome Xp11.2, all resulting in gene fusions involving the Transcription Factor Binding to IGHM Enhancer 3 (TFE3) gene. However, the detailed function of TFE3-fusion proteins in TFE3-fusion associated RCC still remains unknown, and there is no effective treatment for patients with this RCC subtype. In this study we sought to investigate the detailed regulatory network of TFE3-fusion proteins by using doxycycline-inducible HA-tagged TFE3-fusion cell lines and chromatin immunoprecipitation (ChIP)-sequencing. Doxycycline-inducible cell lines that express HA-tagged TFE3-fusion (PRCC-TFE3, PSF-TFE3 and NONO-TFE3) and TFE3 wild-type proteins were established in the HK2 cell line. Genome-wide screening of the binding characteristics of TFE3-fusion proteins and TFE3 wild-type protein in doxycycline-induced cell lines was performed using a chromatin immunoprecipitation sequencing (ChIP-seq) assay. Hierarchical clustering was used to analyze the genes regulated by each type of TFE3-fusion protein compared with TFE3 wild-type protein. The total number of CHIP-seq reads in TFE3 wild-type cell line was 18552874 and enrichment of the promoter region was 1.2. In contrast, the total number of CHIP-seq reads in PRCC-TFE3, PSF-TFE3 and NONO-TFE3 cell lines were 15332969, 20426159 and 17639467, respectively. Enrichment of promoter region in each of the TFE3-fusion cell line was 1.5, 2.4 and 2.2, respectively. There were 80 motifs enriched (Z score &amp;gt;1.5) by expression of PRCC-TFE3 protein compared to TFE3-wild type protein, 104 motifs enriched by PSF-TFE3 protein and 39 motifs by NONO-TFE3 protein expression. Work is ongoing to identify the target genes that are co-regulated in TFE3-fusion cell lines relative to the TFE3 wild-type cell line. Our aim is to identify activated pathways in common among the different TFE3-fusion cell lines compared to the TFE3 wild-type cell line. We anticipate that this study will further our understanding of mechanisms that activate TFE3-fusion proteins facilitating the identification of therapeutic targets for effective treatment of TFE3-fusion associated RCC. Citation Format: Ying Huang, Masaya Baba, Hisashi Hasumi, Yukiko Hasumi, Laura Schmidt, Yoshi Wakabayashi, Jun Zhu, Wenjing Yang, Marston Linehan. Genome-wide mapping of TFE3-fusion target genes. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-113. doi:10.1158/1538-7445.AM2013-LB-113
Cefaclor and Serum Sickness-Like Reaction
Authors: Ronald D. Reynolds
Journal: JAMA (1996)

To the Editor.  —I disagree with Dr Grammer's1admonition that all β-lactam drugs should be avoided in patients who experience a serum sickness reaction to cefaclor. He offers no firm evidence that these patients ever develop serum sickness from other β-lactam drugs. In fact, he cites an article that demonstrates that it is safe to give other cephalosporins to these patients.2  Over the past 9 years, my 3 partners and I have seen about 10 classic serum sickness reaction to cefaclor. We have not avoided subsequent prescription of β-lactam drugs in these patients. Although their reports are anecdotal, none of these patients has had a subsequent serum sickness reaction to any other β-lactam drug.  At the time of a 9-month-old patient's cefaclor serum sickness reaction in February 1991, I had a conversation with Jennifer Stotka, MD, at the Medical Department of Eli Lilly and Co, the manufacturer. I
PHONOGRAPHIC RECORDS OF HEART SOUNDS
Authors: J. E. Ash
Journal: JAMA (1941)

To the Editor:—  My attention has been called to an editorial comment inThe Journal, October 18, which speaks of Dr. Geckeler's reproductions of heart sounds on phonographic records. You make the statement that he no doubt conceived the technic. I thought that you might be interested in knowing that we have on file at the Army Medical Museum records of heart sounds prepared and deposited with us by Dr. Benjamin Manchester of Washington, D. C., in 1939. I understand that Dr. Geckeler knew of these records.
Insulin-Receptor Approaches to Studying Protein Kinase Domain
Authors: Susan R Wente, Ora M Rosen
Journal: Diabetes Care (1990)

Protein tyrosine kinase activity found in the β-subunit of the insulin receptor provides a mechanism by which insulin binding on the outside of the cell transmits its signal across the plasma membrane into the cytosol. The autophosphorylation of the insulin receptor on tyrosyl residues activates the intrinsic tyrosine kinase of the receptor; rendering its ligand independent. Evidence suggests that phosphorylation of tyrosyl residues 1146, 1150, and 1151 in the kinase domain of the β-subunit play a role in activation. Point mutations in the cytoplasmic portion of the β-subunit confirm the above suggestions and indicate that additional sites are important for receptor function. We present methodology for overproducing the cytoplasmic domain of the receptor in the Baculovirus expression system. The protein, produced in insect cells and larvae, is soluble and fully active on autophosphorylation. Like the intact receptor, its autophosphorylation is intramolecular. Because &amp;gt;10 mg of pure protein can be isolated from 1010 insect cells infected with the recombinant Baculovirus encoding the human insulinreceptor kinase domain, sufficient enzyme is available for various studies, including physicochemical analysis. Isolation of β-subunit defects found in the receptors of patients with various forms of diabetes mellitus also implicates the insulin-receptor kinase in insulin action. Finally, α potential model system for the genetic analysis of the insulin-insulin-receptor system with Drosophila melanogaster is noted. Conservation of the deduced amino acid sequence for both α- and β-subunit sequences between humans and insects highlights the significance of this manner of signal transduction throughout nearly 1 billion years of evolution.