tbuckley/cabot-search huggingface dataset:
Case 49-1978
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, James R. Lehrich, Edward P. Richardson, George M. Kleinman
Journal: New England Journal of Medicine (1978)

Presentation of CaseA 66-year-old right-handed woman was admitted to the hospital because of abulia, paraparesis and blindness in the left eye.She was well until 4 1/2 years earlier, when a generalized convulsive seizure occurred. Neurologic evaluation elsewhere, including x-ray films of the skull, a brain scan and an electroencephalogram, was reported to be negative; phenytoin sodium was prescribed. Another seizure occurred 17 months later, preceded by a sensation of vertigo, blurred vision and flashing lights.Thirty-four months before admission a progressive personality change was observed, and the patient became unable to perform routine household chores. She entered another . . .
A Congenital Blood-clotting Anomaly Resembling Coumarin-induced Defect
Authors: F. Nour-Eldin, J. F. Wilkinson
Journal: BMJ (1959)

In spite of the various investigations carried out on the blood-clotting defect caused by the administration of coumarin drugs, their precise mode of action is still undetermined.It is, however, generally agreed that they produce a diminution in the concentration of prothrombin in plasma (Roderick, 1931;Quick, 1937), delay the conversion of prothrombin to thrombin by brain extract (Owen and Bollman, 1948), and reduce the formation of plasma thromboplastin (Biggs, Douglas, and Macfarlane, 1953).Recent studies revealed that the latter defect is most probably due to a deficiency of Christmas factor (Sise, Kimball, and Adamis, 1955: Douglas, 1955;Naeye, 1956; Douglas and Mair, 1958), and Prower factor (Denson, 1958).The purpose of this paper is to present a case with a congenital blood-clotting defect simulating that produced by coumarin drugs.Case Report
Defective Medical Interviews
Authors: DAVID A. NARDONE
Journal: Annals of Internal Medicine (1980)

Letters1 April 1980Defective Medical InterviewsDAVID A. NARDONE, M.D., JAMES B. REULER, M.D., DONALD E. GIRARD, M.D.DAVID A. NARDONE, M.D.Search for more papers by this author, JAMES B. REULER, M.D.Search for more papers by this author, DONALD E. GIRARD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-4-567 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Platt and McMath have written an excellent discussion about interviewing deficiencies (1). A modification of their format to address the flawed data base, especially as it relates to the inordinate time expenditure for the review of the systems, has proved useful in our experience of teaching house staff and students.Current concerns, chief complaint, and other active problems are included under development of a symptom (problem) list (see Table 1). These are elicited directly after the section on the patient's lifestyle. Appropriate openers for this section might be, "What brings you here today?" . . . "What...Reference1. PLATTMCMATH FJ. Clinical hypocompetence: the interview. Ann Intern Med. 1979;91:898-902. LinkGoogle Scholar1. PLATTMCMATH FJ. Clinical hypocompetence: the interview. Ann Intern Med. 1979;91:898-902. LinkGoogle Scholar2. MOLONEYROGERS TD. Medical technology—a different view of the contentious debate over costs. N Engl J Med. 1979;301:1413-9. CrossrefMedlineGoogle Scholar3. PHIBBS B. The abuse of coronary arteriography. N Engl J Med. 1979;301:1394-6. CrossrefMedlineGoogle Scholar1. PLATTMCMATH FJ. Clinical hypocompetence: the interview. Ann Intern Med. 1979, 91:898-902. LinkGoogle Scholar1. PLATTMCMATH FJ. Clinical hypocompetence: the interview. Ann Intern Med. 1979, 91:898-902. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center Portland, OR 97201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1980Volume 92, Issue 4Page: 567-568KeywordsSystematic reviews Issue Published: 1 April 1980 PDF DownloadLoading ...
Association of the <i>toll‐like receptor 2</i> A‐16934T promoter polymorphism with severe atopic dermatitis
Authors: D.‐Y. Oh, R. R. Schumann, L. Hamann, K. Neumann, M. Worm, G. Heine
Journal: Allergy (2009)

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a multifactorial pathogenesis and increasing incidence in the Western world. A genetically determined defective function of pattern recognition receptors such as toll-like receptors (TLRs) has been proposed as a candidate mechanism in the pathogenesis of AD.To study the impact of genetic predisposition of five genes encoding for pattern recognition-related molecules for the phenotype of AD.We examined nine different single-nucleotide polymorphism (SNP) frequencies in the genes encoding TLR1, -2, -4, -9 and the adapter molecule TIRAP by PCR with subsequent melting curve analysis in a case/control cohort of 136 adult AD patients and 129 age and gender matched non-atopic, healthy individuals. TLR2-expression and -function in cells from genotyped individuals were analysed.For the SNPs examined, similar genotype frequencies were found in both groups. In a subgroup of patients suffering from severe AD (SCORAD >50), a significantly increased representation of the A-allele in position -16934 of the tlr2 gene was present (P = 0.004). Constitutive tlr2 mRNA expression in peripheral monocytes was independent of this tlr2 promoter SNP. Stimulation assays indicated that IL-6, but not TNF-alpha secretion following TLR2 stimulation is reduced in homozygous tlr2-16934-A allele carriers.These data indicate that TLR2 is relevant for the phenotype of severe AD in adults.
Talk About Sex: The Battles over Sex Education in the United States
Authors: P. M Boynton
Journal: BMJ (2003)

Sex education is a vital issue for any country, but within nations there are divisions over how it should be delivered. As a psychologist specialising in research on sex and relationship education in the United Kingdom, I was interested to see how a similar Western country (the United States) managed. Janice M Irvine University of California Press, £16.95/$24.95, pp 282 ISBN 0 520 23503 7 www.ucpress.edu Rating: ![Graphic][1]</img>![Graphic][2]</img> Janice Irvine details the struggle between the Christian religious right and liberal sex educators (primarily SIECUS—the Sexuality Information and Education Council of the United … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Once-Daily Treatment with Beclomethasone Dipropionate Nasal Aerosol Effectively Improves the Symptom of Itchy Ear or Palate Associated with Seasonal Allergic Rhinitis
Authors: Niran J. Amar, Frank Hampel, Paul H. Ratner, Julius Van Bavel, Amy Melchior, Sudeesh Tantry
Journal: Journal of Allergy and Clinical Immunology (2013)
Biotransformation and liver-specific functions of human hepatocytes in culture on RGD-immobilized plasma-processed membranes
Authors: Loredana De Bartolo, Sabrina Morelli, Linda C. Lopez, Lidietta Giorno, Carla Campana, Simona Salerno, Maria Rende, Pietro Favia, Loredana Detomaso, Roberto Gristina, Riccardo d’Agostino, Enrico Drioli
Journal: Biomaterials (2004)
The effect of RNAi silencing of p62 using an osmotic polysorbitol transporter on autophagy and tumorigenesis in lungs of K-rasLA1 mice
Authors: Mohammad Ariful Islam, Ji-Young Shin, Cheol-Heui Yun, Chong-Su Cho, Hwi Won Seo, Chanhee Chae, Myung-Haing Cho
Journal: Biomaterials (2013)
Hev b 5 and Hev b 13 as allergen markers to estimate the allergenic potency of latex gloves☆
Authors: Hoong-Yeet Yeang, Siti Arija M. Arif, Monika Raulf-Heimsoth, Yin-Ho Loke, Ingrid Sander, Siti Hawa Sulong, Chee-Heng Lau, Robert G. Hamilton
Journal: Journal of Allergy and Clinical Immunology (2004)
Determinants of glomerular filtration in experimental glomerulonephritis in the rat.
Authors: D A Maddox, C M Bennett, W M Deen, R J Glassock, D Knutson, T M Daugharty, B M Brenner
Journal: Journal of Clinical Investigation (1975)

Pressures and flows were measured in surface glomerular capillaries, efferent arterioles, and proximal tubules of 22 Wistar rats in the early autologous phase of nephrotoxic serum nephritis (NSN). Linear deposits of rabbit and rat IgG and C3 component of complement were demonstrated in glomerular capillary walls by immunofluorescence microscopy. Light microscopy revealed diffuse proliferative glomerulonephritis, and proteinuria was present. Although whole kidney and single nephron glomerular filtration rate (GFR) in NSN (0.8 plus or minus 0.04 SE2 ml/min and 2 plus or minus 2 nl/min, respectively) remained unchanged from values in 16 weight-matched NORMAL HYDROPENIC control rats (0.8 plus or minus 0.08 and 28 plus or minus 2), important alterations in glomerular dynamics were noted. Mean transcapillary hydraulic pressure difference (deltaP) averaged 41 plus or minus 1 mm Hg in NSN versus 32 plus or minus 1 in controls (P LESS THAN 0.005). Oncotic pressures at the afferent (piA) end of the glomerular capillary were similar in both groups ( 16 mm /g) but increased much less by the efferent end (piE) in NSN (to 29 plus or minus 1 mm Hg) than in controls (33 plus or minus 1, P less than 0.025). Hence, equality between deltaP and piE, denoting filtration pressure equilibrium, obtained in control but not in NSN rats. While glomerular plasma flow rate was slightly higher in NSN (88 plus or minus 8 nl/min) than in controls (76 plus or minus 6, P greater than 0.2), the failure to achieve filtration equilibrium in NSN rats was primarily the consequence of a marked fall in the glomerular capillary ultrafiltration coefficient, Kf, to a mean value of 0.03 nl/(s times mm Hg), considerably lower than that found recently for the normal rat, 0.08 nl/(s times mm Hg). Thus, despite extensive glomerular injury, evidenced morphologically and by the low Kf, GFR remained normal. This maintenance of GFR resulted primarily from increases in deltaP, which tended to increase the net driving force for filtration, and thereby compensate for the reduction in Kf.
Biochemical and Functional Abnormalities in Lymphocytes from an Adenosine Deaminase-deficient Patient during Enzyme Replacement Therapy
Authors: John J. Hutton, Dan A. Wiginton, Mary S. Coleman, Steven A. Fuller, Susan Limouze, Beatrice C. Lampkin
Journal: Journal of Clinical Investigation (1981)

Biochemical and immunological properties of lymphocytes were measured repetitively over a period of 40 mo during enzyme replacement by transfusion in a child with adenosine deaminase (ADA) deficiency and severe combined immunodeficiency disease. Catalytically defective ADA protein is present in the child's cells. ADA activity in his lymphocytes is 7 nmol/min per 108 cells with 51 ng of ADA protein/108 cells by radioimmunoassay. ADA activities in normal cord and adult lymphocytes average 193 and 92 nmol/min per 108 cells, respectively, with 429 and 223 ng of ADA protein/108 cells. Deoxy(d)ATP accumulates in the patient's erythrocytes and lymphocytes. Transfusion of irradiated packed erythrocytes partially corrects the metabolic defects. Frank metabolic relapse occurs if transfusions are discontinued for several months. The amounts of dATP in erythrocytes and lymphocytes averaged 13 and 2 times normal, respectively, during periods when transfusions were administered every 2-4 wk. Deoxyguanosine triphosphate and deoxycytidine triphosphate in lymphocytes were normal on 11 occasions, but deoxyribosylthymine triphosphate was ninefold increased. On 11 occasions dATP was measured in lymphocytes and erythrocytes isolated simultaneously. There was a positive, but statistically insignificant, correlation between amounts of dATP in the two types of cells (r = 0.25,P > 0.1). The absolute peripheral lymphocyte count was correlated with the activity of ADA in circulating erythrocytes and with the response of lymphocytes to phytohemagglutinin (r = 0.64, P < 0.01; r = 0.49, P < 0.05). Response of lymphocytes to stimulation by phytohemagglutinin in vitro and absolute peripheral lymphocyte counts were not significantly correlated with levels of dATP in the erythrocyte or lymphocyte during periods of intensive therapy. Although there was objective improvement during enzyme replacement, the child remained immunodeficient and biochemically abnormal.
Cell-delivery therapeutics for liver regeneration☆
Authors: Wenxia Zhang, Lisa Tucker-Kellogg, B.C. Narmada, Lakshmi Venkatraman, Shi Chang, Yin Lu, Nancy Tan, Jacob K. White, Ruirui Jia, Sourav Saha Bhowmick, Shali Shen, C. Forbes Dewey, Hanry Yu
Journal: Advanced Drug Delivery Reviews (2010)
Non–HDL Cholesterol, Apolipoproteins A-I and B<sub>100</sub>, Standard Lipid Measures, Lipid Ratios, and CRP as Risk Factors for Cardiovascular Disease in Women
Authors: Paul M Ridker, Nader Rifai, Nancy R. Cook, Gary Bradwin, Julie E. Buring
Journal: JAMA (2005)

Current guidelines for cardiovascular risk detection are controversial with regard to the clinical utility of different lipid measures, non-high-density lipoprotein cholesterol (non-HDL-C), lipid ratios, apolipoproteins, and C-reactive protein (CRP).To directly compare the clinical utility of total cholesterol, low-density lipoprotein cholesterol (LDL-C), HDL-C, non-HDL-C, apolipoproteins A-I and B(100), high-sensitivity CRP, and the ratios of total cholesterol to HDL-C, LDL-C to HDL-C, apolipoprotein B(100) to apolipoprotein A-I, and apolipoprotein B(100) to HDL-C as predictors of future cardiovascular events in women.Prospective cohort study of 15,632 initially healthy US women aged 45 years or older (interquartile range, 48-59 years) who were enrolled between November 1992 and July 1995. All participants were followed up over a 10-year period for the occurrence of future cardiovascular events.Hazard ratios (HRs) and 95% confidence intervals (CIs) for first-ever major cardiovascular events (N = 464) according to baseline levels of each biomarker.After adjustment for age, smoking status, blood pressure, diabetes, and body mass index, the HRs for future cardiovascular events for those in the extreme quintiles were 1.62 (95% CI, 1.17-2.25) for LDL-C, 1.75 (95% CI, 1.30-2.38) for apolipoprotein A-I, 2.08 (95% CI, 1.45-2.97) for total cholesterol, 2.32 (95% CI, 1.64-3.33) for HDL-C, 2.50 (95% CI, 1.68-3.72) for apolipoprotein B(100), 2.51 (95% CI, 1.69-3.72) for non-HDL-C, and 2.98 (95% CI, 1.90-4.67) for high-sensitivity CRP (P<.001 for trend across all quintiles). The HRs for the lipid ratios were 3.01 (95% CI, 2.01-4.50) for apolipoprotein B(100) to apolipoprotein A-I, 3.18 (95% CI, 2.12-4.75) for LDL-C to HDL-C, 3.56 (95% CI, 2.31-5.47) for apolipoprotein B(100) to HDL-C, and 3.81 (95% CI, 2.47-5.86) for the total cholesterol to HDL-C (P<.001 for trend across all quintiles). The correlation coefficients between high-sensitivity CRP and the lipid parameters ranged from -0.33 to 0.15, and the clinical cut points for CRP of less than 1, 1 to 3, and higher than 3 mg/L provided prognostic information on risk across increasing levels of each lipid measure and lipid ratio.Non-HDL-C and the ratio of total cholesterol to HDL-C were as good as or better than apolipoprotein fractions in the prediction of future cardiovascular events. After adjustment for age, blood pressure, smoking, diabetes, and obesity, high-sensitivity CRP added prognostic information beyond that conveyed by all lipid measures.
Hand, foot and mouth disease in a healthy adult caused by intrafamilial transmission of enterovirus 71
Authors: W-C. Tai, H-J. Hsieh, M-T. Wu
Journal: British Journal of Dermatology (2009)

Journal Article Hand, foot and mouth disease in a healthy adult caused by intrafamilial transmission of enterovirus 71 Get access W‐C. Tai, W‐C. Tai Department of Dermatology, China Medical University, 2, Yuh Der Road, Taichung 404, Taiwan Search for other works by this author on: Oxford Academic Google Scholar H‐J. Hsieh, H‐J. Hsieh Department of Dermatology, China Medical University, 2, Yuh Der Road, Taichung 404, Taiwan Search for other works by this author on: Oxford Academic Google Scholar M‐T. Wu M‐T. Wu Department of Dermatology, China Medical University, 2, Yuh Der Road, Taichung 404, Taiwan Correspondence: Meng‐Tse Wu. E‐mail: d5313@mail.cmuh.org.tw Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 4, 1 April 2009, Pages 890–892, https://doi.org/10.1111/j.1365-2133.2009.09057.x Published: 01 April 2009
A Separate Sacrifice
Authors: Lawrence J. Hergott
Journal: Annals of Internal Medicine (2007)

Ad Libitum18 December 2007A Separate SacrificeLawrence J. Hergott, MDLawrence J. Hergott, MDFrom Denver, CO 80207-3442.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-12-200712180-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The dimly lit hospital corridorlooks at dusk as it did at dawn.The patient list in hand, though,appears much different in the evening light:names, numbers, tasks—added, underlined,crossed off, moved—cryptic symbols of a day's noble work doneand not yet done.Moving to the next bedside,weary,committed,sacrificial mantle felt,I glance toward a westerly windowand am uncaringto be unmovedby the known-rapturous paletteof an evening's fleeting majesty—my soul obscureduntil long after duty and privilege are discharged,the list is satisfied,and its servant late away.now ... Author, Article, and Disclosure InformationAffiliations: From Denver, CO 80207-3442.Current Author Address: Lawrence J. Hergott, MD, 2338 Leyden Street, Denver, CO 80207-3442. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 December 2007Volume 147, Issue 12Page: 896KeywordsFoodHeart ePublished: 18 December 2007 Issue Published: 18 December 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ischemic Stroke and Transient Ischemic Attack in Young Adults
Authors: Ruijun Ji, Lee H. Schwamm, Muhammad A. Pervez, Aneesh B. Singhal
Journal: JAMA Neurology (2012)

Approximately 10% to 14% of ischemic strokes occur in young adults.To investigate the yield of diagnostic tests, neuroimaging findings, and treatment of ischemic strokes in young adults.We retrospectively reviewed data from our Get with the Guidelines-Stroke database from 2005 through 2010.University hospital tertiary stroke center.A total of 215 consecutive inpatients aged 18 to 45 years with ischemic stroke/transient ischemic attack. The mean (SD) age was 37.5 (7) years; 51% were male.There were high incidence rates of hypertension (20%), diabetes mellitus (11%), dyslipidemia (38%), and smoking (34%). Relevant abnormalities were shown on cerebral angiography in 136 of 203 patients, on cardiac ultrasonography in 100 of 195, on Holter monitoring in 2 of 192; and on hypercoagulable panel in 30 of 189 patients. Multiple infarcts were observed in 31% and were more prevalent in individuals younger than age 35 years. Relevant arterial lesions were frequently detected in the middle cerebral artery (23%), internal carotid artery (13%), and vertebrobasilar arteries (13%). Cardioembolic stroke occurred in 47% (including 17% with isolated patent foramen ovale), and 11% had undetermined stroke etiology. The median National Institutes of Health Stroke Scale score was 3 (interquartile range, 0-9) and 81% had good outcome at hospital discharge. Of the 29 patients receiving thrombolysis (median National Institutes of Health Stroke Scale score, 14; interquartile range, 9-17), 55% had good outcome at hospital discharge and none developed symptomatic brain hemorrhage.This study shows the contemporary profile of ischemic stroke in young adults admitted to a tertiary stroke center. Stroke etiology can be determined in nearly 90% of patients with modern diagnostic tests. The causes are heterogeneous; however, young adults have a high rate of traditional vascular risk factors. Thrombolysis appears safe and short-term outcomes are favorable.
PO<sub>2</sub>-dependent Changes in Intrinsic and Extrinsic Tongue Muscle Activities in the Rat
Authors: E. Fiona Bailey, Patrick L. Janssen, Ralph F. Fregosi
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Rationale: Historically, respiratory-related research in sleep apnea has focused exclusively on the extrinsic tongue muscles (i.e., genioglossus, hyoglossus, and styloglossus). Until recently, the respiratory control and function of intrinsic tongue muscles (i.e., inferior and superior longitudinalis, transverses, and verticalis), which comprise the bulk of the tongue, were unknown. Objectives: The current study sought to determine if extrinsic and intrinsic tongue muscles are coactivated in conditions of hypoxemia comparable to that experienced by adults with obstructive sleep apnea. Measurements: Esophageal pressure and EMG activity of an extrinsic (hyoglossus) and an intrinsic (superior longitudinal) tongue muscle were studied in anesthetized, tracheotomized, spontaneously breathing rats. Average EMG activity was compared in a control gas condition (PaO2, 160 ± 12 mm Hg) and in mild isocapnic hypoxia (PaO2, 69 ± 7.2 mm Hg), with and without brief (3-breath) airway occlusions, pre- and postbilateral vagotomy. Main Results: (1) intrinsic and extrinsic tongue muscles are coactivated in mild hypoxia, (2) airway occlusion increased the activities of intrinsic retractor muscles in mild hypoxia, and (3) extrinsic retractor muscles have a steeper rate of rise of activity and an earlier burst onset relative to intrinsic retractor activities in mild hypoxia. Conclusions: These findings support our working hypothesis that airway patency is maintained not simply by activation of extrinsic tongue muscles but by the coactivation of intrinsic and extrinsic protrudor and retractor muscles.
HEART RATE REDUCTION WITH IVABRADINE REDUCES ACTIVATION OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN DOGS WITH CHRONIC HEART FAILURE
Authors: Hani N. Sabbah, Ramesh C. Gupta, Mengjun Wang, Itamar Ilsar, Sharad Rastogi, Michael S. Sabbah, Kaitlin Dye, Andrew Cavanagh
Journal: Journal of the American College of Cardiology (2011)
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells
Authors: Mira Ernkvist, Nathalie Luna Persson, Stéphane Audebert, Patrick Lecine, Indranil Sinha, Miaoliang Liu, Marc Schlueter, Arie Horowitz, Karin Aase, Thomas Weide, Jean-Paul Borg, Arindam Majumdar, Lars Holmgren
Journal: Blood (2008)
Heterosexual AIDS epidemic.
Authors: R. Nandwani, J. Kavanagh, S. Mansfield
Journal: BMJ (1992)

<h3>Aim of special session</h3> To share experience of improvement efforts in the subject areas where resources are limited <sup>1</sup>Ramana KR, <sup>2</sup>Somnath Ganguly, <sup>3</sup>Krishna Nirmalya Sen, <sup>4</sup>Preety Gupta, <sup>5</sup>Arijit Chatterjee <sup>1</sup>National Academy of Construction, Hyderabad, India <sup>2</sup>Calcutta University, Kolkata, India <sup>3</sup>Larsen &amp; Toubro Limited, Kolkata, India <sup>4</sup>Independent Consultant, Goa, India <sup>5</sup>Kalyani University, Kalyani, India