tbuckley/cabot-search huggingface dataset:
Hematopoietic stem cell transplantation: ASBMT/CIBMTR 2010 tandem meeting highlights and discussion
Authors: Noelle V. Frey, David L. Porter
Journal: American Journal of Hematology (2010)

CIBMTR) held their 12th Annual Tandem Meeting this February in Orlando, Florida.This International Transplant Meeting brought together a record 2,570 attendees from 45 countries, and included the state of the art educational and plenary sessions and 478 oral and poster presentations.Recently, the American Journal of Hematology published a series of articles reviewing the ''Top 10 clinically oriented abstracts'' presented at the 2009 American Society of Hematology meeting [1].Given how well this series was received, we believed it would be worthwhile providing a similar review of relevant abstracts from this year's BMT meetings.There has been dramatic progress in this field that we believe is of great interest and importance to the hematology/oncology community.There was an incredible body of work presented and it is misleading to suggest that there is a ''top 10'' list.Many more abstracts than can be presented here are worthy of discussion and recognition and any exclusion of important studies is solely a reflection of space limitation rather than quality of work.We tried to pick abstracts that were important, novel, biologically interesting, and that address either changing or controversial areas in the field.All 10 abstracts are published in full in the February 2010 issue of Biology of Blood and Marrow Transplantation (volume 16, No. 2) and are identified here by their abstract number.Frequency of CD4 1 CD25 hi FOXP3 1 Regulatory T Cells Has Diagnostic and Prognostic Value As a Biomarker for Acute Graft-Versus-Host-Disease (#5)
Absence of Association Between Genetic Variation of the β3-Adrenercjic Receptor and Metabolic Pnenotypes in Oji-Cree
Authors: Robert A Hegele, Stewart B Harris, Anthony JG Hanley, Husain Azouz, Philip W Connelly, Bernard Zinman
Journal: Diabetes Care (1998)

OBJECTIVE To assess the association between the common missense variant, Y64R, in the gene encoding the β3-adrenergic receptor, ADRB3, and intermediate phenotypes related to obesity and NIDDM in Canadian Oji-Cree. RESEARCH DESIGN AND METHODS We determined genotypes of the ADRB3 Y64R polymorphism in 508 clinically and biochemically well-characterized adult Oji-Cree, of whom 115 had NIDDM. We tested for associations with multivariate analysis of variance. RESULTS We found the ADRB3 R64 allele frequency to be 0.40 in this population, which is the highest yet observed in a human population. Furthermore, 15% of subjects were R64/R64 homozygotes, compared with a virtual absence of homozygotes in European study samples. However, we found no statistically significant associations of the ADRB3 Y64R genotype either with the presence of NIDDM, with indexes of obesity, or with intermediate quantitative biochemical traits related to NIDDM. CONCLUSIONS Despite the very high frequency of the ADRB3 R64 allele in this sample of aboriginal people, it was not associated with any metabolic phenotype. This suggests that the ADRB3 R64 allele is probably not a major determinant of obesity or NIDDM in these aboriginal Canadians.
Plasma High-Density Lipoproteins and Ischemic Heart Disease
Authors: Dan Streja, George Steiner, Peter O. Kwiterovich
Journal: Annals of Internal Medicine (1978)

The expression of ischemic heart disease was studied in a large kindred with familial hypercholesterolemia. Tendon xanthomas, multiple generation transmission, and the appearance of bimodality in the distributions of total and low-density lipoprotein cholesterol were found. The segregation ratio was 0.9 in females and 0.43 in males, a difference first apparent during adolescence. The upper quartile of total and low-density lipoprotein cholesterol contained all but two cases of ischemic disease, whereas the lower quartile of high-density lipoprotein cholesterol contained one half of the cases. The ratio of high- to low-density lipoprotein cholesterol (range, 0.06 to 1.6) was less than or equal to 0.20 in each patient with ischemic disease. The association of a low level of high-density lipoprotein cholesterol with ischemic disease persisted after adjustment for differences in other lipids and lipoproteins. A low level of high-density lipoprotein cholesterol, as well as a high level of low-density lipoprotein cholesterol, may influence the development of ischemic heart disease in this disorder.
Diabetes with Coronary Disease — A Moving Target amid Evolving Therapies?
Authors: William E. Boden, David P. Taggart
Journal: New England Journal of Medicine (2009)

The prevalence of diabetes mellitus is rising at an alarming rate and is projected to more than double by 2030.1 The disease currently afflicts 171 million people worldwide, with 23.6 million in the United States. The adverse microvascular and macrovascular consequences of diabetes are well recognized, as is the accompanying accelerated rate of atherosclerosis that predisposes patients to coronary artery disease and to higher rates of myocardial infarction and death. Treatment strategies that are aimed at reducing these events have embraced both optimal medical therapy (lifestyle intervention, vigilant glycemic control, and aggressive secondary prevention) and interventional management (catheter-based and surgical . . .
Acebutolol therapy for ventricular arrhythmia. A randomized placebo-controlled double-blind multicenter study.
Authors: N De Soyza, W Shapiro, P A Chandraratna, W S Aronow, A R Laddu, C H Thompson
Journal: Circulation (1982)

The safety and efficacy of acebutolol in suppressing ventricular ectopy was evaluated in 60 males (average 59 years) using 24-hour Holter recordings and a double-blind, randomized, crossover protocol. Acebutolol, 200 mg and 400 mg thrice daily, was compared with placebo. Only patients who had a mean of at least 30 ventricular premature complexes (VPCs) per hour on three 24-hour control Holter recordings were included. Analysis of Holter recordings revealed greater than 70% reduction in VPCs/hour from control levels during acebutolol therapy in over 50% of the 60 patients; dose-related reduction in the mean number of single and paired VPCs and ventricular tachycardia episodes (p less than 0.05) by acebutolol; and significant, asymptomatic reduction in resting heart rate and blood pressure. All side effects were transient. Acebutolol was discontinued because of side effects in one patient only.
Letter: Complications of laparoscopy.
Authors: J W Crawford
Journal: BMJ (1975)

Of 83 patients who were admitted for outpatient laparoscopic sterilization, 8 chose to remain overnight. 2 of these 8 women underwent laparotomy and sterilization. The 83 patients (not counting the 2 laparotomies) required 89 bed days, which is a shorter period of time than that previously reported for laparoscopy. No complications of any consequence occurred. Most patients were given follow-up appointments. The day approach to laparoscopic sterilization appeared to be popular with the patients.
Double-Blind, Placebo-Controlled (DBPC) Trial of Oral Immunotherapy (OIT) in Peanut Allergic Children
Authors: S.M. Jones, A.M. Scurlock, L. Pons, M. Kulis, T.T. Perry, P. Steele, J. Kamilaris, K.A. Henry, A.W. Burks
Journal: Journal of Allergy and Clinical Immunology (2009)
Communicable disease associated with milk and dairy products in England and Wales 1951-80.
Authors: N S Galbraith, P Forbes, C Clifford
Journal: BMJ (1982)

In England and Wales between 1951 and 1980 233 reported outbreaks of communicable disease attributed to milk or dairy products affected nearly 10 000 people, of whom four died. Tuberculosis and brucellosis have been controlled, but milk-borne outbreaks of salmonellosis and campylobacter enteritis due to raw or defectively pasteurised milk are common and may be increasing in number. Universal heat treatment of milk is an effective preventive measure, and it is regrettable that the continued sale of untreated milk is to be permitted in England and Wales.
MAGNESIUM DEFICIENCY IN THE RAT
Authors: R. W. Brookfield
Journal: BMJ (1934)

EIA ORA Case 4.-A man, aged 62, first seen in January, 1932, he complained of substernal pain radiating to both arms, of six years' duration.The pain was much more easily pro- duced in the last year; moderate exercise, such as light digging, brought it on, and it lasted for two to three minutes.It was always relieved by rest.The left border of the heart was in the mid-clavicular line; there were no murmurs.Blood pressure: 180/90.During the examination the patient had an attack, which he described as being rather worse than usual.It wxas relieved by twenty minutes' rest.He now keeps well with adequate rest.The electrocardiograms are reproduced in Fig. 4. (A) was taken during the attack and (B) followiing it.(A) shows a, depression of the RT interval in all leads, particularly in Leads 2 andl 3. (A) FiG. 4. (B) DISCUSSION In these four cases definit2 changes in the ventricular complexes of the electrocardiograms are demonstrated.These changes resemble those produced by coronary thrombosis.It is agreed that they are not always present, due no doubt to " silent areas " in the myocardium, changes in which do not affect the electrocardiogram.The positive evidence adduced in the above cases and in those previously published points very strongly towards the coronary origin of anginal pain.
Universal Health Care Coverage in the United States: Is It “Slip Slidin' Away”?
Authors: Robert B. Doherty
Journal: Annals of Internal Medicine (2011)

With passage of the Affordable Care Act, affordable health insurance for all Americans is in sight, yet politics could cause it to slip away. A resurgent Republican Party will mount a sustained challenge at the federal and state levels, but the new Congress will not bring about the Affordable Care Act's repeal. More likely, the law's effectiveness could be undermined by congressional restrictions on its implementation, underfunding of programs to improve public health and train more primary care physicians, and resistance by many states to its mandates. Congress could instead seek a bipartisan accord on improving the law, such as by giving the states more options, but this is unlikely in the current polarized environment. This debate is occurring even as the United States faces an unprecedented crisis in access to health insurance coverage, affecting nearly every demographic group, yet the uninsured have largely become an afterthought. Medical professionalism requires a commitment to improving access to care, and physicians could play a crucial role in informing lawmakers that providing all Americans with affordable health care coverage is a moral and medical imperative to prevent needless suffering and death, and must not be allowed to slip away.
Underreporting of AIDS in South Carolina
Authors: Ellis J. Neiburger
Journal: JAMA (1990)

<h3>To the Editor.—</h3> The article entitled "Underreporting of AIDS Cases in South Carolina, 1986 and 1987"<sup>1</sup>was noteworthy in its findings that only 59.5% of reportable cases of acquired immunodeficiency syndrome were actually reported. In September 1987, the Centers for Disease Control revised the definition of acquired immunodeficiency syndrome, adding 31 chronic diseases and 10 lymphomas to the then-existing list of criteria.<sup>2-4</sup> Is it possible that such a discrepancy in reporting, as described in this article, was due primarily to the change in definition (criteria for reporting) of acquired immunodeficiency syndrome that occurred after the data in question were collected, tabulated, and published?
Search for alternatives to animal testing expands
Authors: Phil Gunby
Journal: JAMA (1981)

The Johns Hopkins University, Baltimore, has become the third major research institution this year to agree to seek alternatives to the use of animals for testing the safety of commercial products, and this may be only the beginning. The university's School of Hygiene and Public Health is accepting a $1 million grant from the Cosmetic, Toiletry, and Fragrance Association (CTFA), Washington, DC, to set up a "Center for Alternatives to Animal Testing." Some research will be done at Hopkins but, according to Alan M. Goldberg, PhD, a professor of toxicology who will direct the center, Hopkins also will select investigators from other institutions. A panel of scientists not connected with the university will review research proposals that come in after a symposium is held to identify areas for research. Earlier this year, Rockefeller University, New York City, and Tufts University School of Medicine, Boston, agreed to engage in similar searches
Proarrhythmic Defects in Timothy Syndrome Require Calmodulin Kinase II
Authors: William H. Thiel, Biyi Chen, Thomas J. Hund, Olha M. Koval, Anil Purohit, Long-Sheng Song, Peter J. Mohler, Mark E. Anderson
Journal: Circulation (2008)

Timothy syndrome (TS) is a disease of excessive cellular Ca(2+) entry and life-threatening arrhythmias caused by a mutation in the primary cardiac L-type Ca(2+) channel (Ca(V)1.2). The TS mutation causes loss of normal voltage-dependent inactivation of Ca(V)1.2 current (I(Ca)). During cellular Ca(2+) overload, the calmodulin-dependent protein kinase II (CaMKII) causes arrhythmias. We hypothesized that CaMKII is a part of the proarrhythmic mechanism in TS.We developed an adult rat ventricular myocyte model of TS (G406R) by lentivirus-mediated transfer of wild-type and TS Ca(V)1.2. The exogenous Ca(V)1.2 contained a mutation (T1066Y) conferring dihydropyridine resistance, so we could silence endogenous Ca(V)1.2 with nifedipine and maintain peak I(Ca) at control levels in infected cells. TS Ca(V)1.2-infected ventricular myocytes exhibited the signature voltage-dependent inactivation loss under Ca(2+) buffering conditions, not permissive for CaMKII activation. In physiological Ca(2+) solutions, TS Ca(V)1.2-expressing ventricular myocytes exhibited increased CaMKII activity and a proarrhythmic phenotype that included action potential prolongation, increased I(Ca) facilitation, and afterdepolarizations. Intracellular dialysis of a CaMKII inhibitory peptide, but not a control peptide, reversed increases in I(Ca) facilitation, normalized the action potential, and prevented afterdepolarizations. We developed a revised mathematical model that accounts for CaMKII-dependent and CaMKII-independent effects of the TS mutation.In TS, the loss of voltage-dependent inactivation is an upstream initiating event for arrhythmia phenotypes that are ultimately dependent on CaMKII activation.
Clinician's Manual on Helicobacter Pylori
Authors: R Jones
Journal: Gut (1996)

<h3>Objectives:</h3> To examine relationship between the quality of marital relationship and anxiety among women with breast cancer (BC) in the Kingdom of Saudi Arabia (KSA). <h3>Methods:</h3> This cross-sectional study recruited a consecutive series of 49 married women with BC seen in the Al-Amoudi Breast Cancer Center of Excellence at King Abdulaziz University, Jeddah, KSA in early 2013. Participants completed the Hospital Anxiety and Depression Scale, Spouse Perception Scale, and Quality of Marriage Index forms, and answered questions on demographic and cancer characteristics. <h3>Results:</h3> Anxiety symptoms indicating “possible” anxiety disorder were present in 10.4% and “probable” anxiety disorder in 14.6% (25% total). No significant relationship was found between the quality of marital relationship and anxiety symptoms (B=-0.04, standard error=0.05, t=-0.81, <i>p</i>=0.42). Anxiety was primarily driven by low education, poor socioeconomic status, and young age. <h3>Conclusion:</h3> Anxiety symptoms are prevalent among married women with BC seen in a university-based clinic in the KSA. Further research is needed to determine whether a diagnosis of BC adversely affects marital relationship, and whether this is the cause for anxiety in these women.
Role of ?1 integrins in adhesion and invasion of hepatocellular carcinoma cells
Authors: Akihide Masumoto, Shuichi Arao, Makoto Otsuki
Journal: Hepatology (1999)

To investigate the role of integrins in hepatocellular carcinoma (HCC) invasion, we analyzed the relationship between the expression and activity of β1 integrins and the invasive ability of multiple HCC cell lines. Human HCC cell lines, PLC/PRF/5, Hep3B, HepG2, HLE, HuH7, and C3A cells, had high expression of β1 and α6 subunits, and various levels of α1, α2, α3, and α5 expression as determined by cell surface flow cytometry. Activity of β1 integrins was evaluated by cell adhesion to collagen, fibronectin, and laminin in the presence or absence of the stimulatory anti–β1 monoclonal antibody (mAb) TS2/16. Different types of HCC cells showed various levels of constitutive activity of β1 integrins as assessed by the TS2/16 requirement in cell adhesion. TS2/16 rapidly stimulated constitutively inactive or partially active β1 integrins to fully active states, and as the result, the levels of cell adhesion to each ligand correlated with the expression levels of corresponding β1 integrins. Thus, in the presence of TS2/16 stimulation, the levels of cell adhesion to collagen, fibronectin, and laminin correlated predominantly with the expression levels of α2, α5, and α6, respectively. Remarkably, as a result of in vitro chemoinvasion assay, the levels of constitutive activity of β1 integrins correlated with the invasive ability of HCC cells. The inhibitory anti–β1 mAb 13 almost completely blocked the invasion of PLC/PRF/5 and Hep3B cells that are the most invasive HCC cell lines. Alternatively, the stimulatory anti–β1 mAb TS2/16 strongly inhibited the invasion. These results not only show an essential role of β1 integrins in invasion of HCC cells but also suggest subtle regulatory mechanisms of cell invasion.
Observation of serum estradiol testosterone and immune function in aplastic anemia
Authors: Qingxue Cao, Jianbin Liu
Journal: American Journal of Hematology (1993)

Abstract Letters and correspondence submitted for possible publication must be identified as such. Text length must not exceed 500 words and five bibliographic references. A single concise figure or table may be included if it is essential to support the communication. Letters not typed double‐spaced will not be considered for publication. Letters not meeting these specifications will not be returned to authors. Letters to the Editor are utilized to communicate a single novel observation or finding. Correspondence is to be used to supplement or constructively comment on the contents of a publication in the journal and cannot exceed the restrictions for Letters to the Editor. The Editor reserves the right to shorten text, delete objectional comments and make other changes to comply with the style of the journal. Permission for publication must be appended as a postscript. Submissions must be sent to Marcel E. Conrad, M.D., Associate Editor, American Journal of Hematology, USA Cancer Center, Mobile, Alabama 36688 to permit rapid consideration for publication.
Changes in Sinus Node Function in a Rabbit Model of Heart Failure With Ventricular Arrhythmias and Sudden Death
Authors: Tobias Opthof, Ruben Coronel, Han M. E. Rademaker, Jessica T. Vermeulen, Francien J. G. Wilms-Schopman, Michiel J. Janse
Journal: Circulation (2000)

Heart failure is associated with profound changes in the balance of the autonomic nervous system, such as vagal withdrawal and increased catecholamine levels. It is not known whether the intrinsic sinus node function changes during the progression of heart failure.We implanted transmitters for Holter recording in an established rabbit model of heart failure (n=9) and observed changes in sinus cycle length and the occurrence of arrhythmias during the progression of heart failure. The in vitro sinus cycle length and the responses to acetylcholine and norepinephrine in the isolated right atria were analyzed in 12 rabbits with heart failure and in 6 control rabbits. In vivo cycle length increased in some animals and decreased in others. Sudden death occurred in 3 of 9 rabbits. These rabbits had developed a shorter cycle length than the surviving rabbits. Ventricular tachycardias developed in all but 1 rabbit. The in vitro sinus cycle length increased in heart failure. The response to acetylcholine also increased in heart failure, whereas the response to norepinephrine was unchanged.Changes in intrinsic sinus node function during the progression of heart failure cannot explain the observed decreases in heart rate variability and/or baroreflex sensitivity in this disease, because increased responsiveness to acetylcholine would be expected to cause the opposite.
The Practitioner's Illustrated Dermatology
Authors: Peter N. Horvath
Journal: JAMA (1965)

This manual of dermatology is written primarily for the use of nondermatologists, both medical student and general practitioner. A great deal of thought and effort went into the organization and format. Terminology, clinical descriptions, and therapy are presented in the simplest of terms, avoiding the highly complex and technical language which is a common failing in dermatology textbooks. The descriptions of the various clinical entities are necessarily brief, but adequate. The most interesting feature of this manual is the lavish use of photographs in full color. To my knowledge, this is the first book featuring all colored illustrations at such a reasonable price. The illustrations are well reproduced and arrayed in such a manner that both the text and the photograph of any given clinical condition can be used simultaneously, with photograph on one page, the accompanying text on the opposite page. Therapy receives as much, if not more, attention
Review: Psychological interventions prevent depression after stroke
Authors: Wieslaw Oczkowski
Journal: Annals of Internal Medicine (2008)

ACP Journal ClubNovember 18, 2008Review: Psychological interventions prevent depression after strokeWieslaw Oczkowski, MDWieslaw Oczkowski, MDMcMaster University, Hamilton, Ontario, Canada (W.O.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-10-200811180-02013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationHackett ML, Anderson CS, House A, Halteh C. Interventions for preventing depression after stroke. Cochrane Database Syst Rev. 2008;(3):CD003689. https://pubmed.ncbi.nlm.nih.gov/18646094Clinical Impact RatingsMental Health: Geriatrics: Neurology: Phys Med & Rehab: References1 Hackett ML, Yapa C, Parag V, Anderson CS. Frequency of depression after stroke: a systematic review of observational studies. Stroke. 2005;36:1330-40. [PMID: 15879342] Google Scholar2 Hackett ML, Anderson CS, House AO. Interventions for treating depression after stroke. Cochrane Database Syst Rev. 2004;(3):CD003437. [PMID: 15266484] Google Scholar Author, Article, and Disclosure InformationAffiliations: McMaster University, Hamilton, Ontario, Canada (W.O.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics November 18, 2008Volume 149, Issue 10Page: JC5-13KeywordsActivities of daily livingAntidepressantsAnxietyClinical trialsCognitive impairmentDatabasesDrugsGeriatricsNeurologyPsychiatry and mental healthStroke ePublished: 10 March 2020 Issue Published: November 18, 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE CLINICAL VALUE OF THE PANCREATIC REACTION IN THE URINE, BASED ON OVER 250 ANALYSES
Authors: C. Watson
Journal: BMJ (1908)

THE PANCREATIC RAACTI ¶ INI THE, URINE [NPRIE. 1 inkoduwed into the ctircit of a galvanometer through wich-a ,weak,-current is passings and the resist- ance, being -so arnged byi means -of a rheostat as to enable them to bring the needle to zero on-the scale, psyhical conditions will lead to a deflection of the needle of the galvanometer.The inference is that the psychical change peoduoes some physical change by which the curent-pases less readily, or more readily throughi the BIBLIOGRAPHY.