tbuckley/cabot-search huggingface dataset:
The Unintended Consequences of the “Observation Status” Policy
Authors: Diana Mason
Journal: JAMA (2014)

Januzzi suspects that together with the results from PRAMI, the CvLPRIT findings will lead to guideline changes."What was previously a class III-harm-will eventually become a class I-benefit," he said."Both PRAMI and CvLPRIT were reasonably small studies, but their results are consistent and intuitively logical.Thus, it's not likely we'll need much more before operationalizing this strategy for our patients."
Impact of Periprocedural Bleeding on Incidence of Contrast-Induced Acute Kidney Injury in Patients Treated With Percutaneous Coronary Intervention
Authors: Yohei Ohno, Yuichiro Maekawa, Hiroaki Miyata, Soushin Inoue, Shiro Ishikawa, Koichiro Sueyoshi, Shigetaka Noma, Akio Kawamura, Shun Kohsaka, Keiichi Fukuda
Journal: Journal of the American College of Cardiology (2013)
Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids
Authors: Stephan Blüml, Gordin Zupkovitz, Stefanie Kirchberger, Maria Seyerl, Valery N. Bochkov, Karl Stuhlmeier, Otto Majdic, Gerhard J. Zlabinger, Christian Seiser, Johannes Stöckl
Journal: Blood (2009)
Antagonism between Antibiotics
Authors: L. P. Garrod
Journal: BMJ (1973)

dentistry.Before the dentistry was begun she became unconscious, convulsed, and following resuscitative measures in the dental surgery, was admitted to hospital where, without regaining consciousness, she died some days later.Lum- bar puncture had revealed subarachnoid haem- orrhage and a postmortem examination confirmed the presence of a ruptured congenital cerebral aneurysm.
Chronic Bone Marrow Failure Due to Persistent B19 Parvovirus Infection
Authors: Gary J. Kurtzman, Keiya Ozawa, Bernard Cohen, Gerald Hanson, Ronald Oseas, Neal S. Young
Journal: New England Journal of Medicine (1987)

The B19 parvovirus, which was serendipitously discovered in serum from blood-bank donors in 1975,1 has been associated with several human illnesses. B19 is the etiologic agent of the common childhood exanthem called fifth disease.2 Adults with fifth disease more commonly present with polyarthralgia than skin eruption, and B19 infection has frequently been detected in patients presenting with acute joint symptoms.3 , 4 In patients with underlying hemolysis, B19 infection is the cause of transient aplastic crisis, in which cessation of erythropoiesis leads to absolute reticulocytopenia and abrupt worsening of anemia.5 , 6 In utero infection with B19 has been associated with spontaneous abortion.7 8 9 Laboratory . . .
Is intravenous glucocorticoid therapy better than an oral regimen for asymptomatic cardiac rejection? A randomized trial
Authors: Jon A. Kobashigawa, Lynne W. Stevenson, Jaime D. Moriguchi, Nobuyuki Kawata, Erica Brownfield, Davis C. Drinkwater, Hillel Laks
Journal: Journal of the American College of Cardiology (1993)
Incremental value of prognostic testing in patients with known or suspected ischemic heart disease: A basis for optimal utilization of exercise technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography
Authors: Daniel S. Berman, Rory Hachamovitch, Hosen Kiat, Ishac Cohen, J. Arthur Cabico, Fan Ping Wang, John D. Friedman, Guido Germano, Kenneth Van Train, George A. Diamond
Journal: Journal of the American College of Cardiology (1995)
Experience of coronary care in diabetes.
Authors: A D Harrower, B F Clarke
Journal: BMJ (1976)

During 1968-1973, 94 patients with diabetes were admitted to a coronary care unit (CCU) on 99 occasions with proved myocardial infarction. Altogether 24 of them (25-5%) died, giving an overall mortality at the time of discharge of 24% for the total admissions. This was just significantly higher than the 19% mortality recorded among non-diabetics treated in the same period but was much lower than that among diabetics treated for myocardial infarction before the advent of CCUs. No definite correlation was found between the type of anti-diabetic treatment and either mortality or the incidence of primary ventricular fibrillation. Patients with "poor" control of the diabetes before admission showed a significantly higher mortality than those with "good" control, but there was no significant difference in mortality between those with previous good control and non-diabetics.
A unique role for Stat5 in recovery from acute anemia
Authors: Gregory D Longmore
Journal: Journal of Clinical Investigation (2006)

The precise role of erythropoietin receptor-activated (EpoR-activated) Stat5 in the regulation of erythropoiesis remains unclear. In this issue of the JCI, Menon and colleagues present new experimental data that indicate a distinct role for Stat5 in the regulation of stress-induced erythropoiesis, such as during acute anemic states (see the related article beginning on page 683). A critical function for Stat5 is to promote cell survival, possibly through transcriptional induction of the antiapoptotic protein Bcl-x. In the present experimental system, erythropoietin-Stat5 signals did not induce Bcl-x expression but did induce oncostatin-M. Moreover, oncostatin-M was found to enhance survival of erythroid progenitors. This work differentiates between steady-state (or homeostatic) erythropoiesis and stress-induced erythropoiesis at the level of EpoR signaling.
Just a family medical history?
Authors: Dagmar Schmitz, Urban Wiesing
Journal: BMJ (2006)

Values are important parts of our lives.But values and conscience have different roles in public and private life.They should influence discussion on what kind of health system to deliver.But they should not influence the care an individual doctor offers to his or her patient.The door to "value-driven medicine" is a door to a Pandora's box of idiosyncratic, bigoted, discriminatory medicine.Public servants must act in the public interest, not their own.Contributors and sources: JS is a professional medical ethicist with experience in practising general
In Vivo Analysis of Various Substrates Utilized by Cystathionine -Synthase and O-Acetylhomoserine Sulfhydrylase in Methionine Biosynthesis
Authors: Y. Hacham
Journal: Molecular Biology and Evolution (2003)

To gain insight into the evolution of the methionine biosynthesis pathway, in vivo complementation tests were performed. The substrate specificity of three enzymes that intrinsically use different homoserine-esterified substrates and have different sulfur assimilation pathways was examined: two cystathionine gamma-synthases (the Escherichia coli enzyme that naturally utilizes O-succinylhomoserine [OSH]) and the Arabidopsis thaliana enzyme that naturally exploits O-phosphohomoserine [OPH]. Both of these act through the transsulfuration pathway. The third enzyme investigated was O-acetylhomoserine (OAH) sulfhydrylase of Leptospira meyeri, representing the enzyme that utilizes OAH and operates through the direct sulfhydrylation pathway. All the three enzymes were able to utilize OSH and OAH as substrates, with different degrees of efficiency, but only the plant enzyme was able to utilize OPH as a substrate. In addition to their inherent activity in the transsulfuration pathway, the two cystathionine gamma-synthases were also capable of acting in the direct sulfhydrylation pathway. Based on the phylogenic tree and the results of the complementation tests, we suggest that the ancestral gene was able to act as OAH or OSH sulfhydrylase. In some bacteria and plants, this ancient enzyme most probably evolved into a cystathionine gamma-synthase, thereby maintaining the ability to utilize various homoserine-esterified substrates, as well as various sulfur sources, and thus keeping the multisubstrate specificity of its ancestor. In some organisms, this ancestral gene probably underwent a duplication event, which resulted in a cystathionine gamma-synthase and a separate OAH or OSH sulfhydrylase. This led to the development of two parallel pathways of methionine biosynthesis, transsulfuration and direct sulfhydrylation, in these organisms. Although both pathways exist in several organisms, most seem to favor a single specific pathway for methionine biosynthesis in vivo.
Lowered Aortic Impedance as Therapy for Severe Mitral Regurgitation
Authors: William Grossman
Journal: JAMA (1974)

Sodium nitroprusside was administered intravenously to a patient critically ill with severe mitral insufficiency caused by leakage around a prosthetic mitral valve. Cardiac index increased (1.3 to 3.2 liters/min/sq m) and regurgitant fraction and volume decreased (0.93 to 0.74 for regurgitant fraction, and 16.1 liters/min/sq m to 9.8 liters/min/sq m for regurgitant volume), in association with dramatic clinical improvement. It is suggested that nitroprusside therapy, by decreasing impedance to forward left ventricular output, may be of particular benefit to patients with severe mitral regurgitation. (<i>JAMA</i>230:1011-1013, 1974)
Exercise-Related Hematuria
Authors: Joseph D. Whisnant
Journal: JAMA (1979)

<h3>To the Editor.—</h3> I was pleased to see the excellent article by Siegel et al (241:391, 1979). The problem of exercise related to hematuria has long been of interest to urologists. With the increasing popularity of running in this country in the last several years, the association of gross hematuria with jogging and, more specifically, with marathon running is becoming a more frequently seen problem in the office of the urologist. The syndrome that the authors describe does indeed appear to have a different cause than the renal-based hematurias previously associated with contact sports, particularly boxing. However, I think a word of caution is in order, in that the cause suggested by Blacklock (their reference 3), trauma at the bladder neck area related to the pressure of the interabdominal contents transferred through the posterior bladder wall and to the bladder neck area as being the cause of the bleeding, is
Report Offers Vision For Microbicide Development
Authors: Joan Stephenson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meta-analyses V
Authors: P. Sedgwick
Journal: BMJ (2011)

Researchers undertook a meta-analysis of the analgesic effect of acupuncture.1 Randomised controlled trials of acupuncture for pain were included only if they had three arms incorporating two control groups, with patients randomised to acupuncture, placebo acupuncture, or no acupuncture. Thirteen trials were indentified. Placebo acupuncture included insertion of needles into non-acupuncture points or the use of non-penetrating needles. Separate analyses were undertaken for acupuncture versus placebo acupuncture and placebo acupuncture versus no acupuncture.

The trials used different instruments to record the primary outcome of self reported pain at the end of treatment, including visual analogue scales and ranking scales. Therefore, standardised mean differences were calculated. The results of the meta-analysis for acupuncture compared with placebo acupuncture were presented in a forest plot (figure⇓).



Forest plot of the effectiveness of acupuncture compared with placebo acupuncture in reducing pain at end of treatment. For each trial and the total overall effect, the mean difference in pain was derived as acupuncture minus placebo acupuncture …
Regulation of arachidonic acid metabolites in macrophages.
Authors: W A Scott, J M Zrike, A L Hamill, J Kempe, Z A Cohn
Journal: The Journal of Experimental Medicine (1980)

The lipids of mouse peritoneal macrophages contain high levels (25 mole percent) of esterified arachidonic acid (20:4). Following in vitro exposure to unopsonized zymosan, these cells synthesize and release oxygenated products of 20:4. Maximal levels of zymosan ingestion promote the release of 40-50% of the 20:4 content of cultures without loss of viabilitiy. Release of radiolabel from macrophages prelabeled with [3H]20:4 provides a quantitative measure for the synthesis of 20:4-derived products. Approximately 67% of the released 20:4 is recovered as prostaglandins (PG) (51% PGE and 16% 6-oxo-PGF1 alpha) and the remainder as apolar products tentatively identified as hydroxy-eicosatetraenoic acids. The kinetics of synthesis are comparable for both sets of products. A detailed examination of PGE synthesis indicated the PGE levels rise in parallel with phagocytosis during a continuous exposure of macrophages to zymosan. The concentration of particles determines the initial rate of PGE release, but the time-course of synthesis is finite (approximately 60 min), regardless of the zymosan dose. These observations are compatible with the notion that phagocytosis results in a burst of PG synthesis, the size of which is determined by the phagocytic stimulus. This is supported by the finding that secondary challenges of zymosan promote new rounds of PG synthesis by macrophages.
203 TAFI DEFICIENCY AND ENDOTHELIAL CELL ACTIVATION PLAY A KEY ROLE IN COAGULATION DISORDERS OF PATIENTS WITH SEVERE ACUTE-ON-CHRONIC LIVER FAILURE TREATED BY MARS® SYSTEM
Authors: B. Bismuth, J. Boitard, A. Tournoys, A. Louvet, F. Wartel, S. Dharancy, H. Castel, A. Hollebecque, V. Canva, P. Deltenre, B. Jude, F. Fourrier, P. Mathurin
Journal: Journal of Hepatology (2009)
Cigarette Smoking, Chronic Bronchitis, and Emphysema
Authors: Roger S. Mitchell, Thomas N. Vincent, Giles F. Filley
Journal: JAMA (1964)

Of 150 patients with chronic bronchitis and/or diffuse obstructive pulmonary emphysema, 143 were cigarette smokers, most of them heavy smokers from an early age. Of the 60 who stopped smoking, 44 noted complete or almost complete relief from coughing. These 44 evidenced a lower mortality rate during the 20 years after the onset of their dyspnea than did the 84 who continued to smoke. The lungs of 125 persons who died after age 40 were graded for chronic bronchitis and the quantity of emphysema and black pigmentation. Emphysema and pigment were usually found in close proximity to each other. These three factors correlated well with each other and also with the cigarette smoking histories. The nature of the black pigment is unknown.
TCT-225 Relationship Between the SYNTAX Score and Major Bleeding after PCI: Analysis from the ACUITY Trial
Authors: Mahesh V. Madhavan, Philippe Genereux, Tullio Palmerini, Adriano Caixeta, Mayank Yadav, Ke Xu, Ajay J. Kirtane, Roxana Mehran, Gregg Stone
Journal: Journal of the American College of Cardiology (2013)
Antibodies in malignant disease.
Authors: R J Ablin
Journal: BMJ (1972)

Nutrition has a central role in both primary and secondary prevention of cardiovascular disease yet only relatively recently has food been regarded as a treatment, rather than as an adjunct to established medical and pharmacotherapy. As a field of research, nutrition science is constantly evolving making it difficult for patients and practitioners to ascertain best practice. This is compounded further by the inherent difficulties in performing double-blind randomised controlled trials. This paper covers dietary patterns that are associated with improved cardiovascular outcomes, including the Mediterranean Diet but also low-carbohydrate diets and the potential issues encountered with their implementation. We suggest there must be a refocus away from macronutrients and consideration of whole foods when advising individuals. This approach is fundamental to practice, as clinical guidelines have focused on macronutrients without necessarily considering their source, and ultimately people consume foods containing multiple nutrients. The inclusion of food-based recommendations aids the practitioner to help the patient make genuine and meaningful changes in their diet. We advocate that the cardioprotective diet constructed around the traditional Mediterranean eating pattern (based around vegetables and fruits, nuts, legumes, and unrefined cereals, with modest amounts of fish and shellfish, and fermented dairy products) is still important. However, there are other approaches that can be tried, including low-carbohydrate diets. We encourage practitioners to adopt a flexible dietary approach, being mindful of patient preferences and other comorbidities that may necessitate deviations away from established advice, and advocate for more dietitians in this field to guide the multi-professional team.
Extensible Behavior of Titin in the Miniswine Left Ventricle
Authors: Martin M. LeWinter, Joseph Popper, Mark McNabb, Lori Nyland, Stephen B. Bell, Henk Granzier
Journal: Circulation (2010)

The sarcomeric protein titin is a molecular spring responsible for passive tension and restoring forces of cardiomyocytes. Extension of titin as a function of sarcomere length (SL) has been studied in rodents, which predominantly express the smaller, stiffer N2B titin isoform. Large mammals coexpress roughly equal proportions of N2B and N2BA titin, the larger, more compliant isoform. We hypothesized that extension of titin in relation to SL differs in large mammals and that this difference is functionally important.We characterized the filling pressure-SL relation in diastolic-arrested miniswine left ventricles. SL was 2.15 to 2.25 mum at a filling pressure of approximately 0 mm Hg and reached a maximum of approximately 2.50 mum with overfilling. In the normal filling pressure range, SL ranged from approximately 2.32 to approximately 2.40 mum. We assessed titin extension as a function of SL using immunoelectron microscopy, which allowed delineation of the behavior of specific spring segments. The major isoform difference was that the N2B-Us segment extended approximately 4-fold more as a function of SL in N2B compared with N2BA titin. Using this segment, we estimated sarcomeric force development with a worm-like chain model and found that N2B develops markedly greater force than N2BA titin. The resulting force with coexpression of N2B and N2BA titin is intermediate.In light of murine studies showing that operating SLs are shorter than in miniswine, our results indicate that coexpression of the 2 titin isoforms in large mammals allows longer SLs without the development of excessive diastolic tension.
Abstract 3200: The effect of a sesquiterpenoid from Tussilago farfara on cellular proliferation via the Wnt/β-catenin signaling pathway in colon cancer
Authors: Jae-Ha Ryu, Hua Li, Hwa Jin Lee, Woo-Young Kim
Journal: Cancer Research (2014)

Abstract The β-catenin, a major transcriptional modulator in Wnt signaling, plays a key role in embryogenesis, stem cell renewal and organ regeneration. Abnormal activation of the Wnt/β-catenin signaling pathway frequently induces colon cancer progression. Therefore, the modulation of Wnt/β-catenin signaling pathway has been regarded as a guaranteed target for the treatment of cancer. In the past decade, various pharmacological inhibitors of β-catenin have been identified from medicinal plants. Most of the plant-derived inhibitors are flavonoids such as quercetin, fisetin, silibene and so on. In the present study, we identified tussilagone (TSL), a sesquiterpenoid isolated from the flower buds of medicinal plant Tussilago farfara, as an inhibitor on β-catenin dependent Wnt pathway. TSL suppressed β-catenin/T-cell factor transcriptional activity in a dose dependent manner (2, 10, 30 μM), and also down-regulated β-catenin level both in cytoplasm and nuclei of HEK293 reporter cells when they were activated by Wnt3a or 20 mM LiCl, an inhibitor of glycogen synthase kinase-3β. Since the mRNA level was not affected by TSL up to 30 μM, proteasomal degradation might be responsible for the decreased level of β-catenin. In SW480 and HCT116 colon cancer cell lines, the levels of cytosolic and nuclear β-catenin were decreased significantly by the treatment with 10 μM TSL in Western blot and immunofluorescence analysis. Moreover, TSL also decreased the expression of cyclin D1 and c-myc, the representative target genes of the Wnt/β-catenin signaling pathway, and consequently inhibited the proliferation of colon cancer cells. Taken together, tussilagone from T. farfara may be a new lead compound for the development of therapeutic agents against colon cancer through modulating Wnt/β-catenin signaling pathway. Acknowledgements: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, ICT &amp; Future Planning (Project No 2011-0030699 and 2012R1A1A3013645). Citation Format: Jae-Ha Ryu, Hua Li, Hwa Jin Lee, Woo-Young Kim. The effect of a sesquiterpenoid from Tussilago farfara on cellular proliferation via the Wnt/β-catenin signaling pathway in colon cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3200. doi:10.1158/1538-7445.AM2014-3200
Association of impaired glucose homeostasis with preclinical carotid atherosclerosis in women: Impact of the new American Diabetes Association criteria
Authors: Mario De Michele, Salvatore Panico, Egidio Celentano, Giuseppe Covetti, Mariano Intrieri, Federica Zarrilli, Lucia Sacchetti, Rong Tang, M.Gene Bond, Paolo Rubba
Journal: Metabolism (2002)
Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia
Authors: W L Blalock, P M Navolanic, L S Steelman, J G Shelton, P W Moye, J T Lee, R A Franklin, A Mirza, M McMahon, M K White, J A McCubrey
Journal: Leukemia (2003)
Parts of Italy's law on assisted reproduction are ruled unconstitutional
Authors: F. Turone
Journal: BMJ (2009)

The controversial Italian law on assisted reproduction techniques ( BMJ 2004;328:9, doi:10.1136/bmj.328.7430.9-a) has been amended in part by Italy’s Constitutional Court, which has reaffirmed that the health of the woman must prevail over other considerations.

The court published an outline ruling saying that parts of the current law were contrary to constitutional principles. In particular it ruled as unconstitutional the stipulation that a maximum of three eggs could be fertilised at one time and the obligation that all fertilised eggs had to be transferred back to the womb at the same time.

The details of the decision will be published in a few weeks. Meanwhile many members of the centre right coalition government have …