tbuckley/cabot-search huggingface dataset:
Effect of Adhesive Strips and Dermal Sutures vs Dermal Sutures Only on Wound Closure
Authors: Trenton Custis, April W. Armstrong, Thomas H. King, Victoria R. Sharon, Daniel B. Eisen
Journal: JAMA Dermatology (2015)

<h3>Importance</h3> Although applying adhesive strips to a wound closure has been shown to have outcomes equivalent to those with cuticular suturing, it is unknown whether adhesive strips provide additional benefit compared with dermal suturing alone. <h3>Objective</h3> To determine whether the addition of adhesive strips to a wound closed with buried interrupted subcuticular sutures improves outcomes following wound closure. <h3>Design, Setting, and Participants</h3> A prospective, randomized split-wound intervention was conducted between November 14, 2013, and May 16, 2014, in patients who underwent cutaneous surgical procedures at the University of California, Davis, outpatient dermatology clinic. Fifty-seven patients 18 years or older with postoperative defects of at least 3 cm, resulting from either Mohs micrographic surgical procedures or surgical excision, were screened for participation. Nine patients were excluded and 48 were enrolled. <h3>Interventions</h3> Half of each wound was randomized to receive buried interrupted subcuticular sutures and overlying adhesive strips and the other half received buried interrupted subcuticular sutures only. <h3>Main Outcomes and Measures</h3> At 3 months’ follow-up, each patient and 2 blinded observers evaluated the wound using the Patient Observer Scar Assessment Scale. <h3>Results</h3> The total mean (SD) Patient Observer Scar Assessment Scale score for observers for the side that received a combination of adhesive strips and buried interrupted subcuticular suturing (12.3 [4.8]) and the side that received sutures only (12.9 [6.3]) did not differ significantly at 3 months (<i>P</i> = .32). There was no significant difference in the total patient assessment scale score between the combination closure (14.0 [7.6]) and sutures only (14.7 [7.6]) sides at 3 months (<i>P</i> = .39). There was also no significant difference between the 2 closure methods in terms of mean (SD) scar width (both methods: 1.1 [0.8] mm,<i>P</i> = .89) at follow-up. <h3>Conclusions and Relevance</h3> Combination closure with adhesive strips and buried interrupted subcuticular suturing was not significantly associated with improved overall scar assessment compared with buried interrupted subcuticular suturing alone when evaluated by blinded observers or the patients themselves. Our results do not support the use of adhesive strips as a means to improve cosmetic outcomes or reduce scar width. <h3>Trial Registration</h3> clinicaltrials.gov Identifier:NCT01979497
Thermographical Analysis of the Warmth of the Hands during the Practice of Self-Regulation Method (With 1 color plate)
Authors: Akira Ikemi, Sayuri Tomita, Yoshiaki Hayashida
Journal: Psychotherapy and Psychosomatics (1988)

The changes in surface temperatures of the hands, and the permeation of warmth in the hands during self-regulation method (SRM), a new method of self-control, were studied in 5 trained subjects and in 5 beginners. Temperature changes were measured by thermography. Results indicated that both beginners and trained subjects showed similar significant increases in maximum hand temperatures during SRM, however, trained subjects showed significant increases during the control period as well. Further, both groups showed significant increases in the area of warmth permeation during SRM, however, trained subjects also showed a significant increase during the control period. There was a statistical difference between the two groups for the area of warmth permeation at both the end of the control period and the end of SRM. Thus, in SRM, although beginners seem to be able to raise their hand temperatures in a similar degree to trained subjects, the area of warmth permeation is significantly greater in trained subjects than in beginners. These results indicate that SRM is relatively easy to master for beginners. From these results, the technique of SRM, psychophysiological aspects of SRM and methods of self-control in general, and some issues regarding their clinical applications are discussed.
Principles of Community Health
Authors: Franklin D. Yoder
Journal: JAMA (1961)

While there is no specification as to the student level for which this book is intended, it seems most appropriate for prospective health educators and those in similar categories. Such students who become familiar with its contents will acquire a much needed but yet sometimes neglected background in this important area. Some of the volume's better features include the reading and reference lists for each chapter, good use of graphs, charts, and illustrations, and detailed discussion of mass media. Motivation is given careful consideration. There is adequate attention to community power structure, and references to repositories of health education material will be very helpful. The book does have some shortcomings which should be noted. Devoting a chapter each to radiological and space health is in keeping with the times, but the pressing problem of air pollution has an allotment of only 7 pages. In certain technical details the volume would
Re: Nazareno Suardi, Andrea Gallina, Giuliana Lista, et al. Impact of Adjuvant Radiation Therapy on Urinary Continence Recovery After Radical Prostatectomy. Eur Urol 2014;65:546–51
Authors: Berardino De Bari, Stefano Arcangeli, Filippo Alongi
Journal: European Urology (2014)
Prevention of hepatitis B by vaccine in homosexual men
Authors: D.P. Francis, S.C. Hadler, S.E. Thompson, J.E. Maynard, D.G. Ostrow, N. Altman, E.H. Baff, P. O'Malley, D. Hawkins, F.N. Judson, K. Penley, T. Nylund, G. Christie, F. Meyers, J.N. Moore, A. Gardner, I.L. Doto, J.H. Miller, G. Reynolds, B.L. Murphy, C.A. Schable, B.T. Clark, J.W. Curran, A.G. Redeker
Journal: Journal of Infection (1983)
Novel Insights on Thyroid-Stimulating Hormone Receptor Signal Transduction
Authors: Gunnar Kleinau, Susanne Neumann, Annette Grüters, Heiko Krude, Heike Biebermann
Journal: Endocrine Reviews (2013)

The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of family A G protein-coupled receptors. The TSHR is of great importance for the growth and function of the thyroid gland. The TSHR and its endogenous ligand TSH are pivotal proteins with respect to a variety of physiological functions and malfunctions. The molecular events of TSHR regulation can be summarized as a process of signal transduction, including signal reception, conversion, and amplification. The steps during signal transduction from the extra- to the intracellular sites of the cell are not yet comprehensively understood. However, essential new insights have been achieved in recent years on the interrelated mechanisms at the extracellular region, the transmembrane domain, and intracellular components. This review contains a critical summary of available knowledge of the molecular mechanisms of signal transduction at the TSHR, for example, the key amino acids involved in hormone binding or in the structural conformational changes that lead to G protein activation or signaling regulation. Aspects of TSHR oligomerization, signaling promiscuity, signaling selectivity, phenotypes of genetic variations, and potential extrathyroidal receptor activity are also considered, because these are relevant to an understanding of the overall function of the TSHR, including physiological, pathophysiological, and pharmacological perspectives. Directions for future research are discussed.
William Douglas Park
Authors: Richard Pertwee
Journal: BMJ (2005)

​FormerFormer consultant general surgeon Oldchurch Hospital, Romford, and King George's Hospital, Ilford (b Melbourne, Australia, 1912; q King's College London/St Bartholomew's Hospital 1935; FRCS, MS, SJM), died from bronchopneumonia on 24 August 2004.




Figure 1




William came to Britain in 1924. During the second world war he worked as a specialist in emergency surgery. He subsequently moved to Connaught Hospital, Walthamstow, where he was honorary orthopaedic surgeon. Throughout his career he had interests in orthopaedic, upper gastrointestinal, and cardiac surgery. He was a superb woodcarver, and was commissioned to make a matching pair of crested clocks for the Royal College of Surgeons' committee room. Predeceased by his wife, Pat, he leaves two daughters and five grandchildren.
Fulminant Hepatitis A in Intravenous-Drug Users
Authors: Keith J. Laskin
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 May 1989Fulminant Hepatitis A in Intravenous-Drug UsersKeith J. Laskin, MD, Martin Black, MDKeith J. Laskin, MDSearch for more papers by this author, Martin Black, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-10-845_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: We recently saw a case of fulminant hepatitis A infection in a patient with a history of intravenous drug abuse. The recently reported outbreaks of hepatitis A in drug abusers (1, 2) and the apparently increased incidence of fulminant infection in this patient population suggest a need for close monitoring and aggressive care of what has previously been considered a relatively benign disease.A 24-year-old nonalcoholic white woman at 24 weeks gestation was hospitalized with a 2-week history of fatigue, anorexia, and deepening jaundice. She had a history of intravenous amphetamine abuse, and two episodes of "infectious...References1. Hepatitis A among drug abusers. MMWR. 1988;37:297-305. MedlineGoogle Scholar2. AkriviadisRedeker EA. Fulminant hepatitis A in intravenous drug users with chronic liver disease. Ann Intern Med. 1989;110:838-839. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Temple University Hospital Philadelphia, PA 19140 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHAV infection in chronic liver disease: a rationale for vaccination 15 May 1989Volume 110, Issue 10Page: 845-846KeywordsAddictsAmphetaminesDrug abuseFatigueHepatitis AInfectious diseasesPregnancy Issue Published: 15 May 1989 PDF DownloadLoading ...
Associations of Symptoms and Health-Related Quality of Life: Findings from a National Study of Persons with HIV Infection
Authors: Karl A. Lorenz
Journal: Annals of Internal Medicine (2001)

Background: Health-related quality of life refers to how well people are able to perform daily activities (functioning) and how they feel about their lives (well-being). The relationship between symptoms and health-related quality of life has not been fully explored. Objective: To estimate the association of HIV symptoms with health-related quality of life and with disability days. Design: Prospective cohort study. Setting: HIV providers in 28 urban and 24 rural randomly selected sites throughout the United States. Patients: Nationally representative sample of 2267 adults with known HIV infection who were interviewed in 1996 and again between 1997 and 1998. Measurements: Symptoms, two single-item global measures of health-related quality of life (perceived health and perceived quality of life), and disability days. Results: White patches in the mouth; nausea or loss of appetite; persistent cough, difficulty breathing, or difficulty catching one's breath; and weight loss were associated with more disability days and worse scores on both health-related quality-of-life measures. Headache; pain in the mouth, lips, or gums; dry mouth; and sinus infection, pain, or discharge were associated with worse perceived health. Pain in the mouth, lips, or gums; trouble with eyes; pain, numbness, or tingling of hands or feet; and diarrhea or loose or watery stools were associated with worse perceived quality of life. Headache and fever, sweats, or chills were associated with more disability days. Conclusions: Several symptoms are associated with worse health-related quality of life and more disability days in persons with HIV infection. In such patients, targeting specific symptoms may improve health-related quality of life and reduce disability.
Drug therapy achieves most success in hypertension control
Authors: Milan Korcok
Journal: JAMA (1981)

Physicians who rely on nonpharmacologic means to control hypertension are wasting a lot of time and achieving little success in lowering the blood pressures (BP) of their patients, a Canadian physician told a national conference on prescribing held at Mount Sinai School of Medicine, New York. Furthermore, among those physicians who do prescribe medications, too few prescribe aggressively enough, and too many fail to get patient compliance. The result, said R. Brian Haynes, MD, assistant professor of clinical epidemiology and biostatistics at McMaster University Medical Center in Hamilton, Ontario, is that in only about 30% of hypertensives does treatment result in normalization of BP, despite the fact that most such patients can be successfully treated with available medications. "Studies show," said Haynes, "that fully 98% of physicians recommend weight reduction in overweight patients, and over 90% say they recommend salt restriction to help control blood pressure. "These admonitions are simple
Longitudinal Measure of Glycemic Control and Diabetic Retinopathy
Authors: Barbara E K Klein, Scot E Moss, Ronald Klein
Journal: Diabetes Care (1987)

In a population-based study, 5431 diabetic people in southern Wisconsin who were mature at onset of diabetes were identified, and their charts were reviewed. Recent glycemic control was evaluated from these charts. An index of recent glucose control with at least three glucose determinations abstracted from the doctor's chart was constructed. A sample of 1370 of the 5431 individuals was examined as part of this study. An index of glucose control could be derived for 568 of 674 people using insulin and for 565 of 696 nonusers of insulin. Correlation of the index with the glycosylated hemoglobin obtained at the time of study was significant in insulin users and nonusers.
Performance Characteristics of a New Device for Assessment of Asthmatic Inflammation by Measurement of Exhaled Breath Temperature, the Dunev Thermometer, a Unique Tool for Asthma Management
Authors: T.A. Popov, S. Dunev, T. Kralimarkova, S. Kraeva, L.M. DuBuske
Journal: Journal of Allergy and Clinical Immunology (2007)
The Therapeutic Value of Salicylic Acid
Authors: A. Boggs
Journal: BMJ (1878)

<b>Introduction:</b> Early resistance exercise can improve functional capacity, clinical outcome and survival of patients, leading to a decrease in the harmful effects caused by prolonged bed rest as well as decreased healthcare costs and hospital stay. <b>Objective:</b> To evaluate the influence of early resistance exercise after coronary artery bypass grafting (CABG). <b>Methods:</b> A randomized controlled trial with 37 patients that underwent on-pump CABG between August 2013 and May 2014. Patients were distributed into two groups by simple draw: a control group (n = 20), who received conventional physical therapy, and an intervention group (n = 17), who were subjected to resistance exercise. Pulmonary function and functional capacity were evaluated during the preoperative period and at hospital discharge by spirometry and the six-minute walk test (6MWT). For statistical analysis, the Shapiro-Wilk test, Mann-Whitney test, Student9s t test, Fisher9s exact test and G-test were used. Variables with p &lt; 0.05 were considered significant. <b>Results:</b> Groups were homogeneous in terms of demographic, clinical, and surgical variables. Resistance exercise exerted no effect on pulmonary function when compared to conventional physical therapy. However, intervention group maintained the functional capacity in the two periods evaluated, as there was a significant decrease (p &lt; 0.006) in the functional capacity of control group. In addition, a significant decrease in hospital stay was observed in intervention group (6.3 ± 1.2 vs. 7.6 ± 2.5 days) (p = 0.03). <b>Conclusion:</b> In this study, early resistance exercise after CABG promoted the maintenance of functional capacity and reduced hospital stay compared with conventional physical therapy.
REDUCTION IN OPERATIVE MORTALITY IN THE VERY AGED
Authors: Sidney E. Ziffren
Journal: JAMA (1953)

Most physicians are aware of the tremendous rise in the number of aged persons in our population, but few are aware of the magnitude of that increase. Since the first part of the 20th century the number of persons 65 years of age and older in the United States has quadrupled, while the general population has only doubled. There are 12,269,537 men and women 65 years of age and over in our population today. Of this number it has been estimated that 1,670,000 or approximately 13.6% of this age group are 80 years of age and over. The improvement in life expectancy has been greatest at birth and decreases markedly thereafter, so that today the actual life span at the age of 80 is not much longer than it was in 1900. More persons survive to an older age than before, but, having reached this age, they do not survive
Skin manifestations in a case of trisomy 16 mosaicism
Authors: L.B. Ousager, F. Brandrup, C. Brasch-Andersen, A. Erlendsson
Journal: British Journal of Dermatology (2005)

Journal Article Skin manifestations in a case of trisomy 16 mosaicism Get access L.B. Ousager, L.B. Ousager Department of Clinical Genetics, KKA, Department of Dermatology Lilian Bomme Ousager MD, PhD. E‐mail: lilian.bomme.ousager@ouh.fyns‐amt.dk Search for other works by this author on: Oxford Academic Google Scholar F. Brandrup, F. Brandrup Department of Clinical Genetics, KKA, Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar C. Brasch‐Andersen, C. Brasch‐Andersen Department of Clinical Genetics, KKA, Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar A. Erlendsson A. Erlendsson Department of Audiology, Odense University Hospital, Sdr. Boulevard 29, DK‐5000 Odense C, Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 154, Issue 1, 1 January 2006, Pages 172–176, https://doi.org/10.1111/j.1365-2133.2005.06928.x Published: 01 January 2006 Article history Accepted: 22 February 2005 Published: 01 January 2006
Bivalirudin versus Unfractionated Heparin during Percutaneous Coronary Intervention
Authors: Adnan Kastrati, Franz-Josef Neumann, Julinda Mehilli, Robert A. Byrne, Raisuke Iijima, Heinz Joachim Büttner, Ahmed A. Khattab, Stefanie Schulz, James C. Blankenship, Jürgen Pache, Jan Minners, Melchior Seyfarth, Isolde Graf, Kimberly A. Skelding, Josef Dirschinger, Gert Richardt, Peter B. Berger, Albert Schömig
Journal: New England Journal of Medicine (2008)

Whether bivalirudin is superior to unfractionated heparin in patients with stable or unstable angina who undergo percutaneous coronary intervention (PCI) after pretreatment with clopidogrel is unknown.We enrolled 4570 patients with stable or unstable angina (with normal levels of troponin T and creatine kinase MB) who were undergoing PCI after pretreatment with a 600-mg dose of clopidogrel at least 2 hours before the procedure; 2289 patients were randomly assigned in a double-blind manner to receive bivalirudin, and 2281 to receive unfractionated heparin. The primary end point was the composite of death, myocardial infarction, urgent target-vessel revascularization due to myocardial ischemia within 30 days after randomization, or major bleeding during the index hospitalization (with a net clinical benefit defined as a reduction in the incidence of the end point). The secondary end point was the composite of death, myocardial infarction, or urgent target-vessel revascularization.The incidence of the primary end point was 8.3% (190 patients) in the bivalirudin group as compared with 8.7% (199 patients) in the unfractionated-heparin group (relative risk, 0.94; 95% confidence interval [CI], 0.77 to 1.15; P=0.57). The secondary end point occurred in 134 patients (5.9%) in the bivalirudin group and 115 patients (5.0%) in the unfractionated-heparin group (relative risk, 1.16; 95% CI, 0.91 to 1.49; P=0.23). The incidence of major bleeding was 3.1% (70 patients) in the bivalirudin group and 4.6% (104 patients) in the unfractionated-heparin group (relative risk, 0.66; 95% CI, 0.49 to 0.90; P=0.008).In patients with stable and unstable angina who underwent PCI after pretreatment with clopidogrel, bivalirudin did not provide a net clinical benefit (i.e., it did not reduce the incidence of the composite end point of death, myocardial infarction, urgent target-vessel revascularization, or major bleeding) as compared with unfractionated heparin, but it did significantly reduce the incidence of major bleeding. (ClinicalTrials.gov number, NCT00262054.)
666 OCCULT HBV INFECTION IN PERIPHERAL BLOOD MONONUCLEAR CELLS OF PATIENTS WITH B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA
Authors: L. Sala, D. Rossi, F. Caldera, M. Burlone, M. Cerri, R. Minisini, E. Falleti, P. Toniutto, L. Franzosi, C. Fabris, G. Gaidano, M. Pirisi
Journal: Journal of Hepatology (2008)
The "last joint" syndrome in ankylosing spondylitis.
Authors: K Veerapen, P A Dieppe, R Veerapen, H B Griffith
Journal: BMJ (1986)

CorrectionPrevalence of antibody to HTLV-IH in haemophiliacs in the Unaited Kinlgdom In the Patients, methods, and results section of this short report (19 July, p 175) it was stated that "20 (60%/) of 324 patients with haemophilia B who were tested were positive..."This should have read "20 (6%) of 324 patients with haemophilia B who were tested were positive."We apologise for this error.
CD: The Virtual Surgeon: ACL Reconstruction
Authors: S. Brooks
Journal: BMJ (1999)

George Bentley, Russell E Windsor, Andrew Williams TVF Multimedia, £363, CD Rom Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Anterior cruciate reconstruction is an aspect of surgery that encroaches on the working practice or social scene of most doctors, either through patients requiring advice as to whether to contemplate surgery or through knowing family members, friends, or colleagues who have sustained anterior cruciate ligament … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
The Effect of ACTH on the Plasma and Urinary Corticoids in Normal Elderly Persons and in Patients with Senile Psychosis
Authors: V. A. KRAL, B. GRAD, R. C. PAYNE, J. BERENSON
Journal: American Journal of Psychiatry (1967)

As part of an investigation to determine the relationship between stress tolerance and the development of senile psychosis, the authors measured the effect of ACTH, administered intramuscularly, on the plasma and urinary corticoids in 30 normal aged persons and 32 patients with senile psychosis. The patients tended to have higher plasma corticoid levels and lower urinary corticoid amounts per gram creatinine, but the differences were not statistically significant. The authors suggest that the greater response of patients with senile psychosis to physical and psychological stress might be due to pituitary or hypothalamic dysfunction rather than to a difference in corticoid output, and further investigation of these possibilities seems warranted.