tbuckley/cabot-search huggingface dataset:
Abstract 340: Kaempferol inhibits angiogenesis and tumorigenesis by regulating Akt-HIF, cMyc-p21, and ERRα genes
Authors: Haitao Luo, Gary Rankin, Ann Federoff, Noelle Juliano, Bing-Hua Jiang, Yi C. Chen
Journal: Cancer Research (2010)

Abstract This study was designed to investigate kaempferol's effects on VEGF expression and angiogenesis in ovarian cancer cells and the underlying mechanisms/pathways responsible for these effects. Kaempferol's effects on VEGF expression in ovarian cancer cells, OVCAR-3 and A2780/CP70, were studied with ELISA and a VEGF promoter reporter assay. In-vitro and in-vivo angiogenesis were studied with human umbilical vein endothelial cells and chicken embryo chorioallantoic membranes, respectively. Expression or phosphorylation of pertinent genes in ovarian cancer cells treated with kaempferol (0-160 µM) was examined with RT-qPCR, western blot, or ELISA as appropriate. To investigate kaempferol's effects on VEGF expression, the expression of certain genes was either enhanced by transfection of plasmid DNA or knocked down by transfection of siRNA, and the resultant effects evaluated by using a VEGF promoter reporter assay or RT-qPCR. Our study found that kaempferol is effective in inhibiting VEGF expression, in-vitro and in-vivo angiogenesis, and in-vivo tumorigenesis at physiologically relevant concentrations (e.g. 40 µM). We further looked into mechanisms/pathways for these effects, and confirmed a role for Akt and HIF-1α in kaempferol's inhibition on VEGF expression. We discovered that a new HIF-1α-independent pathway is also involved in VEGF regulation. Our results showed that kaempferol executes its effects on VEGF expression through regulating ERRα but not PPARGC1A in OVCAR-3 and A2780/CP70 cells. We also identified cMyc/p21 as a novel pathway for kaempferol's inhibitory effects on VEGF expression in ovarian cancer cells. Our study found that kaempferol is effective for angio-prevention in ovarian cancer cells, and new information was obtained on the mechanisms/pathways for kaempferol's effects. As a dietary flavonoid, kaempferol is a good candidate for angio-prevention and primary prevention of ovarian cancers, and it deserves further investigation in animal studies and human trials. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 340.
Upregulation of epidermal surface molecule expression in primary and ultraviolet-induced lesions of lupus erythematosus tumidus
Authors: A. Kuhn, M. Sonntag, C. SunderkOtter, P. Lehmann, D. Vestweber, T. Ruzicka
Journal: British Journal of Dermatology (2002)

Summary Background Lupus erythematosus tumidus (LET), a photosensitive skin disorder with characteristic clinical and histological features, has not been generally accepted as a subset of cutaneous lupus erythematosus (CLE). Objectives To analyse the expression of epidermal surface molecules in skin biopsy specimens from patients with LET and to relate the results to other variants of CLE, such as discoid lupus erythematosus (DLE) and subacute CLE (SCLE). Methods In total, 45 patients with different subtypes of CLE were included in the study, and cryostat sections from primary and ultraviolet (UV) A- and UVB-induced skin lesions were investigated using immunohistochemical methods. Results In contrast to healthy controls, skin lesions of LET showed upregulation of intercellular adhesion molecule-1 (ICAM-1) and histocompatibility class II molecules (HLA-DR), with an expression pattern resembling that seen in DLE and SCLE. Furthermore, staining with a monoclonal antibody against 27E10, a distinct marker for cell activation and differentiation, revealed intense focal or band-like labelling of all epidermal layers independent of the type of lesion. Conclusions Expression of epidermal surface molecules such as ICAM-1, HLA-DR and 27E10 is equally upregulated in primary and UV-induced lesions of patients with LET, DLE and SCLE. These results support our recent clinical findings that LET represents a distinct subset of CLE with a similar immunopathomechanism rather than a different disease.
Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure.
Authors: T W Kurtz, L Simonet, P M Kabra, S Wolfe, L Chan, B L Hjelle
Journal: Journal of Clinical Investigation (1990)

The spontaneously hypertensive rat (SHR) exhibits alterations in the renin-angiotensin-aldosterone system which are similar to those that characterize patients with "nonmodulating" hypertension, a common and highly heritable form of essential hypertension. Accordingly, we determined whether the inheritance of a DNA restriction fragment length polymorphism (RFLP) marking the renin gene of the SHR was associated with greater blood pressure than inheritance of a RFLP marking the renin gene of a normotensive control rat. In an F2 population derived from inbred SHR and inbred normotensive Lewis rats, we found the blood pressure in rats that inherited a single SHR renin allele to be significantly greater than that in rats that inherited only the Lewis renin allele. To the extent that the SHR provides a suitable model of "nonmodulating" hypertension, these findings raise the possibility that a structural alteration in the renin gene, or a closely linked gene, may be a pathogenetic determinant of increased blood pressure in one of the most common forms of essential hypertension in humans.
In search of a good death: A good death is an oxymoron without consideration of mental health
Authors: H. G Prigerson
Journal: BMJ (2003)

EDITOR—Ellershaw and Ward are to be commended for their useful review of “evidence-based guidelines on symptom control, psychological support, and bereavement… to facilitate a 'good death.'”1 Their recommendations for diagnosing dying are concrete, thorough, and practical.

By contrast, they write only two sentences about the provision of psychological care: “Patients' insight into their condition should be …
100 TRANSLOCATION OF BACTERIAL DNA IS ASSOCIATED WITH WORSENING OF THE HYPERKINETIC SYSTEMIC CIRCULATION AND OF INTRA-HEPATIC ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CIRRHOTIC AND ASCITES
Authors: P. Bellot, J.C. García-Pagán, R. Francés, J.G. Abraldes, J.M. González-Navajas, M. Navasa, M. Pérez-Mateo, J. Such, J. Bosch
Journal: Journal of Hepatology (2009)
A Neurologist Looks at Death
Authors: John J. McCutchen
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Organ transplantation is again receiving considerable attention. Recent donor hearts for heart transplantation have been offered by relatives of patients "dying" from central nervous system disease or injury. While these donors were chosen after considerable thought and planning, discussion of the brain's role in "death" needs to be reopened to assure that not merely reasonable, but extraordinary standards be set to protect the rights of prospective donors. There are many legal, moral, and religious as well as ethical considerations in organ transplantation; however, this discussion will be limited to a clinical definition of death and suggested standards for evaluation of death under this structure. Some clinical basis for the definition of life is necessary. Certainly life is present in molecular matter, cells, organ systems, and in the integrated individual which represents the human. The most basic definition of life is continued biological activity, and this property is
Mucosal nitric oxide may tonically suppress airways plasma exudation.
Authors: J S Erjefält, I Erjefält, F Sundler, C G Persson
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

In a search for airway epithelial mechanisms that may affect the subepithelial microcirculation, we examined plasma exudation responses to NG-nitro-L-arginine-methyl ester (L-NAME), a nitric oxide synthase (NOS) inhibitor. L-NAME was applied topically on the tracheal mucosa of guinea pigs that had previously received 125I-albumin and/or colloidal gold particles (5 nm) intravenously. Luminal entry of plasma was determined by the levels of 125I-albumin in tracheal lavage fluid. Topical L-NAME (2.2, 9, and 22 mumol), but not intravenous L-NAME (375 mumol/kg), produced plasma exudation into the airway lumen (p < 0.01 to p < 0.001). The L-NAME enantiomer NG-nitro-D-arginine-methyl ester (D-NAME, 9 mumol) produced no exudative response. Coadministration of L-arginine (27 mumol) abolished the L-NAME-induced exudation. The extravasated plasma was distributed in the lamina propria and between epithelial cells (colloidal gold). The epithelial surface structure (scanning electron microscopy) appeared intact. Staining with nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase suggested that epithelial basal may contain nitric oxide synthases. We suggest that endogenously released nitric oxide from epithelial or other superficial cells tonically suppresses the macromolecular permeability of the subepithelial microcirculation.
Financing of Medical Care in the United States
Authors: Herman M. Somers
Journal: New England Journal of Medicine (1966)

THE well publicized revolution in medical care is widely understood to be a product of the explosive changes in science and technology. The more cautious revolution in financing, which has accompanied it, is in some quarters suspiciously regarded as a vulgar machination of bookkeepers, or a political contrivance or perhaps even a dark plot. The interdependence of both revolutions (I am acceding to common jargon, for actually both were painful evolutionary processes) as well as the impersonal character of their sources should be self-evident. Both were inescapable. Few but the more sentimental and nostalgic would claim that the net advantages . . .
Neurodevelopmental Outcomes in Children With Congenital Heart Disease: Evaluation and Management
Authors: Bradley S. Marino, Paul H. Lipkin, Jane W. Newburger, Georgina Peacock, Marsha Gerdes, J. William Gaynor, Kathleen A. Mussatto, Karen Uzark, Caren S. Goldberg, Walter H. Johnson, Jennifer Li, Sabrina E. Smith, David C. Bellinger, William T. Mahle
Journal: Circulation (2012)

The goal of this statement was to review the available literature on surveillance, screening, evaluation, and management strategies and put forward a scientific statement that would comprehensively review the literature and create recommendations to optimize neurodevelopmental outcome in the pediatric congenital heart disease (CHD) population.A writing group appointed by the American Heart Association and American Academy of Pediatrics reviewed the available literature addressing developmental disorder and disability and developmental delay in the CHD population, with specific attention given to surveillance, screening, evaluation, and management strategies. MEDLINE and Google Scholar database searches from 1966 to 2011 were performed for English-language articles cross-referencing CHD with pertinent search terms. The reference lists of identified articles were also searched. The American College of Cardiology/American Heart Association classification of recommendations and levels of evidence for practice guidelines were used. A management algorithm was devised that stratified children with CHD on the basis of established risk factors. For those deemed to be at high risk for developmental disorder or disabilities or for developmental delay, formal, periodic developmental and medical evaluations are recommended. A CHD algorithm for surveillance, screening, evaluation, reevaluation, and management of developmental disorder or disability has been constructed to serve as a supplement to the 2006 American Academy of Pediatrics statement on developmental surveillance and screening. The proposed algorithm is designed to be carried out within the context of the medical home. This scientific statement is meant for medical providers within the medical home who care for patients with CHD.Children with CHD are at increased risk of developmental disorder or disabilities or developmental delay. Periodic developmental surveillance, screening, evaluation, and reevaluation throughout childhood may enhance identification of significant deficits, allowing for appropriate therapies and education to enhance later academic, behavioral, psychosocial, and adaptive functioning.
A Case of an Esophageal Cancer Patient Surviving for Over 4 Years After Chemoradiotherapy and Subsequent Chemotherapy
Authors: M. Misawa, F. Yamamura, Y. Mori, Y. Sugihara, Y. Wada, K. Wakamura, T. Hayashi, H. Miyachi, S.-e. Kudo
Journal: Annals of Oncology (2013)
Anuria Secondary to Renovascular Disease
Authors: Henry T. Smith
Journal: JAMA (1968)

A patient with a solitary kidney had acute renal failure secondary to thrombosis of the renal artery. Physicians should be aware that occlusive renal artery disease is a potentially reversible cause of acute renal failure. Although early diagnosis and correction are desirable, it is difficult to establish rigid time limits for reversible renal damage. Since there is adequate clinical evidence that the kidney may regain significant function upon relief of prolonged ischemia, an aggressive approach should be taken in this situation.
Alveolitis after treatment with amiodarone.
Authors: S A Riley, S E Williams, N J Cooke
Journal: BMJ (1982)

later the patient was in slow junctional rhythm (35 beats/min), hypotensive, and poorly perfused.He responded promptly to ventricular pacing.At the time his other treatment included digoxin, frusemide, and isosorbide dinitrate.There was no electrolyte abnormality.No rise in enzyme activity occurred, and his serum digoxin concentration was 2 2 mg/l.Amiodarone was withdrawn and intermittent sinus node activity returned next day; within two days periods of normal sinus rhythm were noted.Spontaneous ventricular tachycardia requiring cardioversion recurred, however, so an atrioventricular sequential pacer was inserted and amiodarone reinstituted.As no other treat- ment was suitable for this patient he was discharged with this regimen. CommentSinus bradycardia and sinoatrial block have been described as side effects of amiodarone,' but to our knowledge sinus arrest has not been reported and no such case has been notified either to Sanofi Inc, the US agent for the manufacturers of the drug, or to the Food and Drug Administration.Both patients had normal sinus node automati- city as shown by corrected sinus node recovery times within the normal range, this being considered the best available test of sinus node auto- maticity and possibly of overall node function.4Amiodarone depressed automaticity by inhibiting phase 4 depolarisation in the sinus node of rabbits in vitro,5 and these observations suggest that such a mechanism may account for this potentially lethal complication in susceptible patients.
HLA class I antigens on the hepatocyte membrane during recovery from acute hepatitis B virus infection and during interferon therapy in chronic hepatitis B virus infection
Authors: Massimo Pignatelli, Jenny Waters, Dave Brown, Andrew Lever, Sten Iwarson, Zsuzsa Schaff, Robert Gerety, Howard C. Thomas
Journal: Hepatology (1986)

In a chimpanzee model of acute type B hepatitis, at the time of onset of hepatitis B virus replication and before the development of immunity to hepatitis B virus, interferon is present in the plasma. This is followed by an increase in the display of HLA class I, but not class II proteins, on the hepatocyte membrane. In chronic hepatitis B virus infection, there is a low density of HLA class I protein display on the infected hepatocyte. Administration of alpha-interferon enhances HLA display and in many cases is followed by a transaminase elevation, seroconversion of HBe antigen to antibody and disappearance of hepatitis B virus DNA from serum, changes implying clearance of infected hepatocytes. Successful response to interferon therapy may be predicted by a rapidly rising serum beta 2-microglobulin, a component of the HLA class I molecule, during the first 2 weeks of therapy, before the rise in transaminases.
Recent Health Gains for Adults
Authors: James Michael McGinnis
Journal: New England Journal of Medicine (1982)

The emerging profile of health data for Americans suggests some interesting and encouraging trends. Life expectancy for all age groups has increased substantially in this century. The recent gain for adults warrants special comment.An examination of the United States experience with deaths from cardiovascular disease offers some important and possibly historic lessons. As deaths from infectious disease have declined, chronic diseases (and especially cardiovascular diseases) have become prominent on the mortality tables. Heart disease has been the leading cause of death in this country since 1910, except for the years of the influenza pandemic (1918 to 1920). Stroke has . . .
Echocardiographic correlates of left ventricular structure among 844 mildly hypertensive men and women in the Treatment of Mild Hypertension Study (TOMHS).
Authors: P R Liebson, G Grandits, R Prineas, S Dianzumba, J M Flack, J A Cutler, R Grimm, J Stamler
Journal: Circulation (1993)

BACKGROUND Echocardiography provides a noninvasive means of assessing left ventricular (LV) structure and evidence of LV wall remodeling in hypertensive persons. The relation of demographic, biological, and other factors with LV structure can be assessed. METHODS AND RESULTS LV structure was assessed by M-mode echocardiograms for 511 men and 333 women with mild hypertension (average blood pressure, 140/91 mm Hg). Measurements of LV wall thicknesses and internal dimensions were made, and estimates of LV mass indexes and other derivations of structure were calculated. LV hypertrophy criteria were based on previously reported echocardiographic population studies of normal subjects. These measures were compared by age, sex, race, body mass index, systolic blood pressure, antihypertensive drug use, physical activity, alcohol intake, cigarette smoking, and urinary sodium excretion. Despite virtual absence of ECG-determined LV hypertrophy, 13% of men and 20% of women had echocardiographically determined LV hypertrophy indexed by body surface area (g/m2), and 24% of men and 45% of women had LV hypertrophy indexed by height (g/m). Black participants had slightly higher mean levels of wall thickness than nonblack participants but similar LV mass. Systolic blood pressure and urinary sodium excretion were significantly and independently associated with LV mass index and LV hypertrophy using both g/m2 and g/m. Body mass index was significantly related to LV mass index and LV hypertrophy using g/m. Smoking was significantly associated with LV mass index, i.e., using continuous measurement but not using the dichotomy for LV hypertrophy. CONCLUSIONS This study of a large population of men and women with mild primary hypertension, largely without ECG evidence of LV hypertrophy, showed a substantial percentage of participants with echocardiographically determined LV hypertrophy. LV mass indexes correlated positively with systolic blood pressure, body mass index, urinary sodium excretion, and smoking.
Access to heart surgery for smokers. Inform, don't punish.
Authors: S Mullick
Journal: BMJ (1993)

determine the level of services rather than to ration special services to particular patients, and it would be up to the government to decide the level of services offered to people.Smokers might argue that the revenue generated by their smoking sustains more than just the NHS budget.Secondly, failure rates derived by statistics do not apply to individual people.It is unethical to deny a patient the benefit of any treatment simply to reduce failure rates.Even the authors admit that the success rate of the operation is not spectacular.Probably there is a stronger case to look at the operation itself than at the imperfect people who have it.The third argument is that the damage caused by smoking is self inflicted.If we extend that argu- ment we might be tempted to deny services to people who do not adhere to a "healthy" lifestyle or strict medical advice; we would end up with an NHS treating only saints.
Impact of Regurgitant Orifice Height for Mechanism of Aortic Regurgitation
Authors: Kentaro Shibayama, Hiroyuki Watanabe, Shunsuke Sasaki, Keitaro Mahara, Minoru Tabata, Toshihiro Fukui, Shuichiro Takanashi, Tetsuya Sumiyoshi, Hitonobu Tomoike, Takahiro Shiota
Journal: JACC. Cardiovascular imaging (2013)
Contact Sensitivity to Sorbic acid in 'Unguentum Merck'
Authors: EricM. Saihan, Roger R. M. Harman
Journal: British Journal of Dermatology (1978)

Journal Article Contact Sensitivity to Sorbic acid in ‘Unguentum Merck’ Get access EricM. Saihan, EricM. Saihan Department of Dermatology, Bristol Royal Infirmary, Bristol Dr E. M. Saihan, Department of Dermatology, Bristol Royal Infirmary, Bristol BS2 8HW. Search for other works by this author on: Oxford Academic Google Scholar Roger R. M. Harman Roger R. M. Harman Department of Dermatology, Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue 5, 1 November 1978, Pages 583–584, https://doi.org/10.1111/j.1365-2133.1978.tb02030.x Published: 01 November 1978
Cardiac dysfunction in patients with systemic lupus erythematosus and antiphospholipid syndrome
Authors: D. Paran, D. Caspi, D. Levartovsky, O. Elkayam, I. Kaufman, I. Litinsky, G. Keren, B. Koifman
Journal: Annals of the Rheumatic Diseases (2006)

<b>Objective:</b> To comparatively assess the parameters of systolic and diastolic cardiac function in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). <b>Methods:</b> Consecutive patients (n = 74) who were free of cardiovascular symptoms were divided into four groups: (1) SLE (n = 23); (2) SLE with antiphospholipid antibodies (aPL; n = 18); (3) SLE with APS (n = 20); and (4) primary antiphospholipid syndrome (PAPS; n = 13). Pulsed, continuous, colour Doppler echocardiography, and M-mode and B-mode studies were performed. <b>Results:</b> Left ventricular end diastolic and end systolic dimensions were higher in SLE as compared with patients with PAPS (p = 0.022 and 0.022, respectively), with a trend towards a lower fractional shortening in SLE (p = 0.07), suggesting systolic dysfunction. Parameters of diastolic function were more impaired in patients with APS, reflected by lower left ventricular and right ventricular E wave to A wave (E:A) ratios in patients with APS (groups 3, 4) compared with those without APS (groups 1, 2; 1.15 (0.40) <i>v</i> 1.49 (0.43), p = 0.001 and 1.19 (0.31) <i>v</i> 1.49 (0.41), p = 0.001, respectively) and a more prolonged left ventricular isovolumic relaxation time (IVRT; 94.2 (24.6) <i>v</i> 84.4 (17) ms, respectively, p = 0.055). Patients with APS were older than those without APS (47.12 (14.86) <i>v</i> 34.29 (12.6), p = 0.0001). Patients with SLE were younger than those with PAPS (38.19 (14.68) <i>v</i> 48.53 (13.97), p = 0.023). <b>Conclusion:</b> Abnormal echocardiographic findings were detected frequently in asymptomatic patients with SLE or PAPS. Although patients with SLE were younger, left ventricular systolic function was more impaired in patients with SLE compared with those with PAPS, whereas left ventricular and right ventricular diastolic function, as reflected by IVRT and E:A ratios, were significantly more impaired in patients with APS.