tbuckley/cabot-search huggingface dataset:
[440] COMPARTMENTALIZATION OF HEPATITIS C VIRUS QUASISPECIES IN TUMORAL AND NON-TUMORAL HEPATOCYTES ISOLATED BY LASER-CAPTURE MICRODISSECTION
Authors: R. Sobesky, V. Thiers, F. Rimlinger, N. Derian, A. Dos Santos, A.M. Roque-Afonso, D. Samuel, C. Brechot, C. Feray
Journal: Journal of Hepatology (2007)
880 HYALURONIC ACID AND LIVER STIFFNESS REDUCTION IN HIV–HEPATITIS-C (HCV) COINFECTED PATIENTS TREATED WITH A CCR5 INHIBITOR MARAVIROC (MVC) IN A RANDOMIZED CONTROLLED TRIAL (MAICOL STUDY – 48-WEEK ANALYSIS)
Authors: P. Nasta, E. Chari, M.R. Giralda, F. Pasotti, F. Borghi, D. Ricotta, F. Castelli, G. Carosi
Journal: Journal of Hepatology (2013)
Primary Tumours of the Suprarenal Gland and their Removal by Operation
Authors: H. Morris
Journal: BMJ (1899)

would call attention to two cases which I reported in the JOURNAL of January 7th, 1893, of removal of tumours of the suprarenal capsule.'One of these cases was operated upon in I885, and is referred to and illustrated in my book on Surgical Diseases of the Kidney published in that year.The other case was operated upon in March, 1892.To these I can add a third case operated upon in March, 1894.As the two former were only briefly reported in a course of lectures on the Surgery of the Kidney, and, as the third case has not been published, I propose giving a short account of each of them under this their proper title, and adding a few remarks on the pathology, clinical features, and surgical treatment of adrenal tumours.CASE I.
1112-143 Chronic effect of cardiac resynchronization therapy on functional mitral regurgitation in the advanced systolic heart failure
Authors: Kazuya Murata, Rikimaru Oyama, Nobuaki Tanaka, Yasuyuki Hatano, Eizo Akagawa, Akihiko Shimizu, Masunori Matsuzaki
Journal: Journal of the American College of Cardiology (2004)
A case of natural killer cell monoclonal expansion during efalizumab treatment in a patient with psoriasis
Authors: M. Caproni, W. Volpi, C. Chiarini, E. Antiga, B. Giomi, P. Fabbri
Journal: British Journal of Dermatology (2009)

Journal Article A case of natural killer cell monoclonal expansion during efalizumab treatment in a patient with psoriasis Get access M. Caproni, M. Caproni Department of Dermatological Sciences, University of Florence, Via della Pergola 58/60, 50121 Florence, Italy Search for other works by this author on: Oxford Academic Google Scholar W. Volpi, W. Volpi Department of Dermatological Sciences, University of Florence, Via della Pergola 58/60, 50121 Florence, Italy Search for other works by this author on: Oxford Academic Google Scholar C. Chiarini, C. Chiarini Department of Dermatological Sciences, University of Florence, Via della Pergola 58/60, 50121 Florence, Italy Search for other works by this author on: Oxford Academic Google Scholar E. Antiga, E. Antiga Department of Dermatological Sciences, University of Florence, Via della Pergola 58/60, 50121 Florence, Italy Search for other works by this author on: Oxford Academic Google Scholar B. Giomi, B. Giomi Department of Dermatological Sciences, University of Florence, Via della Pergola 58/60, 50121 Florence, Italy Search for other works by this author on: Oxford Academic Google Scholar P. Fabbri P. Fabbri Department of Dermatological Sciences, University of Florence, Via della Pergola 58/60, 50121 Florence, Italy Correspondence: Paolo Fabbri. E‐mail: fabbri@unifi.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 4, 1 April 2009, Pages 896–897, https://doi.org/10.1111/j.1365-2133.2009.09059.x Published: 01 April 2009
The end of the heparin pump?
Authors: N. R Grubb, P. Bloomfield, C. A Ludlam
Journal: BMJ (1998)

Antithrombotic therapy with intravenous unfractionated heparin has been the mainstay of early treatment of patients with venous thromboembolic disease and unstable angina. On a typical medical ward several patients will be attached to syringe drivers containing heparin. Management of these patients is time consuming: heparin infusions have to be made up daily, intravenous cannulas resited, blood samples analysed for monitoring of coagulation control, and doses adjusted on the basis of these results. The potential for dosing errors is high: even in trials with criteria for dose monitoring, over 60% of patients are overanticoagulated or underanticoagulated 24 hours after the start of heparin therapy.1 Newer low molecular weight heparins are much easier to administer, but do they have other advantages over unfractionated heparin?

The benefit of heparin treatment to patients with venous thromboembolic disease and unstable angina has been shown in several trials. In the only placebo controlled trial of heparin in pulmonary embolism the mortality rate was so much lower in treated patients that the trial was stopped.2 In unstable angina several randomised trials have indicated a trend towards reduced risk of death and non-fatal myocardial infarction in patients treated with aspirin …
T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)
Authors: David F. Tough, Siquan Sun, Jonathan Sprent
Journal: The Journal of Experimental Medicine (1997)

Lipopolysaccharide (LPS) from gram-negative bacteria causes polyclonal activation of B cells and stimulation of macrophages and other APC. We show here that, under in vivo conditions, LPS also induces strong stimulation of T cells. As manifested by CD69 upregulation, LPS injection stimulates both CD4 and CD8+ T cells, and, at high doses, stimulates naive (CD44lo) cells as well as memory (CD44hi) cells. However, in terms of cell division, the response of T cells after LPS injection is limited to the CD44hi subset of CD8+ cells. In contrast with B cells, proliferative responses of CD44hi CD8+ cells require only very low doses of LPS (10 ng). Based on studies with LPS-nonresponder and gene-knockout mice, LPS-induced proliferation of CD44hi CD8+ cells appears to operate via an indirect pathway involving LPS stimulation of APC and release of type I (α, β) interferon (IFN-I). Similar selective stimulation of CD44hi CD8+ cells occurs in viral infections and after injection of IFN-I, implying a common mechanism. Hence, intermittent exposure to pathogens (gram-negative bacteria and viruses) could contribute to the high background proliferation of memory–phenotype CD8+ cells found in normal animals.
Lenient rate control is as effective as strict rate control for preventing cardiovascular events in AF
Authors: Robby Nieuwlaat
Journal: Annals of Internal Medicine (2010)

ACP Journal Club17 August 2010Lenient rate control is as effective as strict rate control for preventing cardiovascular events in AFRobby Nieuwlaat, PhD, Stuart J. Connolly, MDRobby Nieuwlaat, PhDPopulation Health Research Institute, Hamilton, Ontario, Canada (R.N., S.J.C.)Search for more papers by this author, Stuart J. Connolly, MDPopulation Health Research Institute, Hamilton, Ontario, Canada (R.N., S.J.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-4-201008170-02004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationVan Gelder IC, Groenveld HF, Crijns HJ, et al; Race II Investigators. Lenient versus strict rate control in patients with atrial fibrillation. N Engl J Med. 2010;362:1363-73. https://pubmed.ncbi.nlm.nih.gov/20231232Clinical Impact RatingsGIM/FP/GP: Cardiology: References1 Nieuwlaat R, Capucci A, Camm AJ, et al. Atrial fibrillation management: a prospective survey in ESC member countries: the Euro Heart Survey on Atrial Fibrillation. Eur Heart J. 2005;26:2422-34. [PMID: 16204266] Google Scholar2 European Heart Rhythm Association; Heart Rhythm Society, Fuster V, Rydén LE, Cannom DS, et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation—executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation). J Am Coll Cardiol. 2006;48:854-906. [PMID: 16904574] Google Scholar Author, Article, and Disclosure InformationAuthors: Robby Nieuwlaat, PhD; Stuart J. Connolly, MDAffiliations: Population Health Research Institute, Hamilton, Ontario, Canada (R.N., S.J.C.)This article was published at Annals.org on 3 August 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 August 2010Volume 153, Issue 4Page: JC2-4KeywordsAtrial fibrillationExercise therapyHeart failureHeart rateHemorrhageHospitalizationsMortalityMyocardial infarctionRacial and ethnic issuesStable coronary artery disease ePublished: 17 August 2010 Issue Published: 17 August 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Role of SPA-1 in Phenotypes of Chronic Myelogenous Leukemia Induced by BCR-ABL–Expressing Hematopoietic Progenitors in a Mouse Model
Authors: Kohei Kometani, Misayo Aoki, Shin Kawamata, Yoriko Shinozuka, Takumi Era, Masafumi Taniwaki, Masakazu Hattori, Nagahiro Minato
Journal: Cancer Research (2006)

Abstract SPA-1 is a negative regulator of Rap1 signal in hematopoietic cells, and SPA-1-deficient mice develop myeloproliferative disorders (MPD) of long latency. In the present study, we showed that the MPDs in SPA-1−/− mice were associated with the increased hematopoietic stem cells expressing LFA-1 in bone marrow and their premature mobilization to spleen with extensive extramedullary hematopoiesis, resembling human chronic myelogenous leukemia (CML). We further showed that human BCR-ABL oncogene caused a partial down-regulation of endogenous SPA-1 gene expression in mouse hematopoietic progenitor cells (HPC) and immature hematopoietic cell lines. Although both BCR-ABL-transduced wild-type (wt) and SPA-1−/− HPC rapidly developed CML-like MPD when transferred to severe combined immunodeficient mice, the latter recipients showed significantly increased proportions of BCR-ABL+ Lin− c-Kit+ cells compared with the former ones. Serial transfer experiments revealed that spleen cells of secondary recipients of BCR-ABL+ wt HPC failed to transfer MPD to tertiary recipients due to a progressive reduction of BCR-ABL+ Lin− c-Kit+ cells. In contrast, SPA-1−/− BCR-ABL+ Lin− c-Kit+ cells were sustained at high level in secondary recipients, and their spleen cells could transfer MPD to tertiary recipients, a part of which rapidly developed blast crisis. Present results suggest that endogenous SPA-1 plays a significant role in regulating expansion and/or survival of BCR-ABL+ leukemic progenitors albeit partial repression by BCR-ABL and that Rap1 signal may represent a new molecular target for controlling leukemic progenitors in CML. (Cancer Res 2006; 66(20): 9967-76)
Methemoglobinemia Associated With Well Water
Authors: Louis W. Miller
Journal: JAMA (1971)

A case of infant methemoglobinemia associated with milk formula prepared from well water containing excess nitrates occurred in Texas. The existence of numerous rural wells with high nitrate concentrations has been documented in various areas through the United States in the past and again in Texas in 1969. These private wells and certain rural municipal water supplies represent a possible source for cases of methemoglobinemia.
The Medical Society and Long-Term Patient Care
Authors: Pierre Salmon
Journal: JAMA (1966)

To the Editor:—  A question sometimes overlooked among patients with long-term illness is whether those needing medical or nursing support are receiving it in the proper place at the proper time. As the variety of available services becomes greater and their costs mount, it is correspondingly important to have an effective review process in operation.  Rising costs of long-term patient care are inevitable in meeting demands for improvement in the quality of care. Medicare legislation is probably the most compelling force in this change because, almost for the first time, a third party payer has indicated that good quality care is the desired goal, and that reasonable costs will be paid. The Medicare program includes payment for home health services in an effort to broaden the range of support. It is probable that this action arises from the expectation that patients presently receiving nursing-home care might be able to be
More recruitment from ethnic minority groups would improve NHS's service, report says
Authors: Seye Abimbola
Journal: BMJ (2007)

Recruiting more people from ethnic minority groups into the NHS in England would improve the care of patients, cut costs, and increase the skills of NHS staff, says a report by the government agency Race for Health.

The 64 page report sets out ways that trusts can increase the number of people from ethnic minorities that it employs, through pre-recruitment support, better information on access to jobs, and help for people who qualified overseas. The report says that recruiting people from ethnic minority groups for new specialist services that are aimed at those groups would improve health outcomes in those communities.

The report …
Photodynamic therapy of non-melanoma malignant tumours of the skin using topical δ-amino levulinic acid sensitization and laser irradiation
Authors: K. SVANBERG, T. ANDERSSON, D. KILLANDER, I. WANG, U. STENRAM, S. ANDERSSON-ENGELS, R. BERG, J. JOHANSSON, S. SVANBERG
Journal: British Journal of Dermatology (1994)

Journal Article Photodynamic therapy of non‐melanoma malignant tumours of the skin using topical δ‐amino levulinic acid sensitization and laser irradiation Get access K. SVANBERG, K. SVANBERG Department of Oncology. Lund University Hospital, S‐221 85 Lund, Sweden Search for other works by this author on: Oxford Academic Google Scholar T. ANDERSSON, T. ANDERSSON Department of Oncology. Lund University Hospital, S‐221 85 Lund, Sweden Search for other works by this author on: Oxford Academic Google Scholar D. KILLANDER, D. KILLANDER Department of Oncology. Lund University Hospital, S‐221 85 Lund, Sweden Search for other works by this author on: Oxford Academic Google Scholar I. WANG, I. WANG Department of Oncology. Lund University Hospital, S‐221 85 Lund, Sweden Search for other works by this author on: Oxford Academic Google Scholar U. STENRAM, U. STENRAM Department of Pathology. Lund University Hospital, S‐221 85 Lund, Sweden Search for other works by this author on: Oxford Academic Google Scholar S. ANDERSSON‐ENGELS, S. ANDERSSON‐ENGELS Atomic Physics Division, Lund Institute of Technology, PO Box 118. S‐221 00 Lund, Sweden Search for other works by this author on: Oxford Academic Google Scholar R. BERG, R. BERG Atomic Physics Division, Lund Institute of Technology, PO Box 118. S‐221 00 Lund, Sweden Search for other works by this author on: Oxford Academic Google Scholar J. JOHANSSON, J. JOHANSSON Atomic Physics Division, Lund Institute of Technology, PO Box 118. S‐221 00 Lund, Sweden Search for other works by this author on: Oxford Academic Google Scholar S. SVANBERG S. SVANBERG Atomic Physics Division, Lund Institute of Technology, PO Box 118. S‐221 00 Lund, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue 6, 1 June 1994, Pages 743–751, https://doi.org/10.1111/j.1365-2133.1994.tb03412.x Published: 01 June 1994 Article history Accepted: 01 November 1993 Published: 01 June 1994
Preoperative Chemotherapy for Breast Cancer
Authors: Clifford Hudis, Shanu Modi
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effectiveness of Ampicillin Against Gram-Negative Bacteria
Authors: Kenneth N. Anderson, Roger P. Kennedy, James J. Plorde, Jonas A. Shulman, Robert G. Petersdorf
Journal: JAMA (1964)

Three hundred gram-negative bacteria consisting of approximately 50 strains each of<i>Escherichia coli, Proteus mirabilis, Klebsiella-Aerobacter</i>, paracolon sp, indol-fermenting strains of<i>Proteus</i>, and<i>Pseudomonas aeruginosa</i>were tested against a new penicillin, alpha amino benzyl penicillin (ampicillin) in vitro. The drug showed excellent activity against<i>E coli</i>- and<i>P mirabilis</i>but was less effective against the other organisms than agents already available. There was good correlation between results of sensitivity tests performed by the tube dilution and single disc techniques. Forty patients with urinary tract infections were treated with 2 to 3 gm per day of ampicillin for two weeks. In general,<i>E coli</i>infections were most amenable to therapy and patients with acute uncomplicated pyelonephritis responded better than patients with chronic bacteriuria. Diarrhea occurred in six patients and was the only bothersome side effect associated with ampicillin.
Strokes Due to Vertebro-Basilar Disease: Infarction, Vascular Insufficiency and Hemorrhage of the Brain Stem and Cerebellum
Authors: Oscar Sugar
Journal: JAMA (1965)

This book offers the only good English compilation of detailed data on embryology, anatomy, and clinicopathological correlates of disorders of the vertebral and basilar arteries. The authors contend that 50% of all "strokes" involve the vertebrobasilar system and they decry procrustean attempts to tailor clinical findings into the localized eponymic syndromes of classical neurology. Most of these were not vascular in origin and pathologic confirmation was often lacking. An area of infarction may be due to occlusion of its primary artery of supply, but it may also be due to occlusion at some distance in the presence of stenosis or variation in vascular distribution. Some softenings occur without any occlusion; this may happen with a rise in blood pressure instead of a fall. Distinction is made between episodes of cerebrovascular insufficiency months or years apart (more common with carotid disease) and episodes which occur at intervals of hours, days, or
Community-Based Use of Chemotherapy and Hormonal Therapy for Early-Stage Breast Cancer: 1987-2000
Authors: Linda C. Harlan, Limin X. Clegg, Jeffrey Abrams, Jennifer L. Stevens, Rachel Ballard-Barbash
Journal: Journal of Clinical Oncology (2006)

We describe trends in the use of chemotherapy and hormonal therapy by nodal and estrogen receptor (ER) status in women with early-stage breast cancer.Cases were randomly sampled from the population-based Surveillance, Epidemiology and End Results (SEER) program and physician verified treatment was examined. A total of 9,481 women, aged 20 years and older, diagnosed with early-stage breast cancer in 1987 to 1991, 1995, and 2000 were included in the study.The use of chemotherapy plus tamoxifen increased between 1995 and 2000 for women with node-negative, ER-positive breast cancer > or = 1 cm (8% to 21%). Nearly 23% of women with node-negative and ER-positive tumors > or = 1 cm received no adjuvant therapy. The use of chemotherapy alone increased to nearly 60% in women with node-negative, ER-negative tumors > or = 1 cm (48% to 59%). However, in 2000, 16% of women with node-positive and ER-negative tumors received no adjuvant therapy and an additional 6% received tamoxifen alone. The influence of age can clearly be seen. Chemotherapy is given much less often in women 70 years or older.The results from SEER areas across the United States suggest that physicians quickly responded to publications and guidelines regarding breast cancer therapy. The lack of definitive findings from clinical trials on the use of adjuvant therapy in women 70 years and older may explain the lower use in this group of women.
Treatment of Appendicitis at the Massachusetts General Hospital (1937-1959)
Authors: Benjamin A. Barnes
Journal: JAMA (1962)

In analyzing mortality data from 5,800 cases of appendicitis, the cases were grouped according to the pathological stage of the disease at the time of initial treatment. The mortality rates ranged from 0.1% (appendix inflamed but not gangrenous) to 13.1% (appendiceal abscess not treated initially by appendectomy). The deaths in recent years were caused by nonseptic complications as much as by peritonitis or metastatic abscesses. In 4 out of 5 cases the preoperative diagnosis was correct. In 1 out of 6 cases the appendix was found to be perforated. No trend towards earlier referral for surgery was noted over a 20-year period. Further reductions in mortality depend on improved general support of the patient and on control of nonseptic complications.
The Electric Treatment of Poliomyelitis
Authors: Theodore Diller
Journal: JAMA (1910)

<h3>To the Editor:—</h3> In the short paper on "The Treatment of Poliomyelitis from the Neurologist's Point of View" published inThe JournalOctober 22, Dr. B. Sachs says: "Muscular exercise is the chief aim in the treatment, and for that reason one must follow the simple rule that in treating the paralyzed muscles that form of current is to be used which gives the best contraction with currents of moderate strength." I believe that all who have paid attention to this matter will agree with this statement of Dr. Sachs. But in many cases of poliomyelitis no contraction whatever can be produced by "currents of moderate strength." And indeed in many cases no contraction, or only a feeble one, can be produced by even painful currents. No good can be accomplished by using electricity unless the current produces muscular contraction. And in many cases muscular contraction can be produced only
Abscess of the Antrum
Authors: Byron J. Bailey
Journal: JAMA (1983)

It is both an honor and a challenge to review and comment on the landmark publication entitled "Diagnosis and Treatment of Abscess of the Antrum," by Joseph H. Bryan, MD, published in the Oct 5, 1889, issue ofThe Journal. Bryan's original manuscript was presented to those assembled at the Section of Laryngology and Otology at the 40th Annual Meeting of the American Medical Association, which was held in June 1889. The great significance of this publication is apparent when it is placed in the context of the location and time of its publication. European physicians were providing most of the advances in rhinology. The brief period between 1886 and 1893 is the interval during which physicians began to become aware of the frequent need for surgical intervention in the management of chronic sinus infection. In 1886, Mikulicz<sup>1</sup>published his important work in Germany, recommending the transnasal, surgical management