Avascular Necrosis of the Femoral Head Associated with Sickle Cell Trait (AS Hemoglobin)
Authors: RALPH G. RATCLIFF
Journal: Annals of Internal Medicine (1962)

Case Studies1 August 1962Avascular Necrosis of the Femoral Head Associated with Sickle Cell Trait (AS Hemoglobin)RALPH G. RATCLIFF, M.D., MELVYN D. WOLF, M.D.RALPH G. RATCLIFF, M.D.Search for more papers by this author, MELVYN D. WOLF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-2-299 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis communication reports the occurrence of avascular necrosis of the femoral head in 2 patients with sickle cell trait (AS hemoglobin). Although this is known to occur in both sickle cell anemia (SS hemoglobin) (1) and in some of its genetic variants (2), we are unaware of any reports of avascular necrosis of the femoral head in association with pure sickle cell trait.METHODSStandard hematologic techniques were utilized for complete blood counts (3). Sickle cell tests were performed using 2% sodium metabisulfite (3).Fetal hemoglobin content was determined by the method of Singer, Chernoff, and Singer (4).Hemoglobin electrophoresis...References1. TANAKACLIFFORDAXELROD KRGOAR: Sickle cell anemia (homozygous S) with aseptic necrosis of femoral head. Blood 11: 998, 1956. CrossrefMedlineGoogle Scholar2. SMITHCONLEY EWCL: Clinical features of the genetic variants of sickle cell disease. Bull. Johns Hopkins Hosp. 94: 289, 1954. MedlineGoogle Scholar3. CARTWRIGHT GE: Diagnostic Laboratory Hematology, 2d Ed., Grune & Stratton, New York, 1958. Google Scholar4. SINGERCHERNOFFSINGER KAIL: Studies in abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation. Blood 6: 413, 1951. CrossrefMedlineGoogle Scholar5. Spinco Technical Bulletin 6095A, November, 1961, p. 14. Google Scholar6. 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OBERBRUNOWEINBERGJONESWEINER WBMSJBFML: Fatal intravascular sickling in a patient with sickle-cell trait. New Engl. J. Med. 263: 947, 1960. CrossrefMedlineGoogle Scholar21. MCCORMICK WF: Pathology of sickle cell trait. Presented at fifty-seventh annual meeting of American Association of Pathologists and Bacteriologists, Memphis, Tennessee, April 28-30, 1960. Cited by Ober (20). Google Scholar22. WINTROBE MM: Clinical Hematology, 5th Ed., Lea & Febiger, Philadelphia, 1961, p. 688. Google Scholar23. WINTROBE MM: Clinical Hematology, 5th Ed., Lea & Febiger, Philadelphia, 1961, p. 675. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, OhioFrom the Departments of Medicine and Surgery, University of Cincinnati College of Medicine; the Medical Service, Hematology Section, and the Surgical Service, Orthopedic Section, Cincinnati Veterans Administration Hospital, Cincinnati. Ohio.Requests for reprints should be addressed to Ralph G. Ratcliff, M.D., Veterans Administration Hospital, 3200 Vine Street, Cincinnati 20, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTotal hip arthroplasty: Concerns and precautions in sickle-cell traitMultiple Diaphyseal Bone Infarcts in a Patient With Sickle Cell TraitHistopathology of aseptic necrosis of the femoral head in sickle cell diseaseSickle-cell hip necrosis and intraosseous pressureOstéonécrose drépanocytaire de la tête fémorale et pression intraosseuseRetinopathy in haemoglobin C traitMalignant fibrous histiocytoma in bone infarct. 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