New Case of Acute Hepatitis Following the Consumption of Shou Wu Pian, a Chinese Herbal Product Derived from <i>Polygonum multiflorum</i>
Authors: Gabriela Mazzanti, Lucia Battinelli, Claudia Daniele, Claudio Maria Mastroianni, Miriam Lichtner, Simona Coletta, Sergio Costantini
Journal: Annals of Internal Medicine (2004)

Letters6 April 2004New Case of Acute Hepatitis Following the Consumption of Shou Wu Pian, a Chinese Herbal Product Derived from Polygonum multiflorumGabriela Mazzanti, PharmD, PhD, Lucia Battinelli, DSc, PhD, Claudia Daniele, PharmD, Claudio Maria Mastroianni, MD, PhD, Miriam Lichtner, MD, PhD, Simona Coletta, MD, PhD, and Sergio Costantini, DScGabriela Mazzanti, PharmD, PhDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., Lucia Battinelli, DSc, PhDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., Claudia Daniele, PharmDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., Claudio Maria Mastroianni, MD, PhDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., Miriam Lichtner, MD, PhDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., Simona Coletta, MD, PhDFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy., and Sergio Costantini, DScFrom University La Sapienza and Istituto Superiore di Sanità, Rome, Italy.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-7-200404060-00042-w3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Shou Wu Pian (Shenzou-Chinese Medical Centre, Amsterdam, the Netherlands) is a herbal product constituted by powdered root of Polygonum multiflorum Thunb (Polygonaceae). It is used in China as a tonic and antiaging remedy. In western countries, it is commonly found in herb shops and grocery stores in Chinatowns.Two patients with hepatotoxicity related to Shou Wu Pian have been described previously. The first one was a 31-year-old pregnant Chinese woman who had taken the product to treat hair loss (1). She had experienced a similar reaction with a preparation of the same herb about 2 years ...References1. But PP, Tomlinson B, Lee KL. Hepatitis related to the Chinese medicine Shou-wu-pian manufactured from Polygonum multiflorum. Vet Hum Toxicol. 1996;38:280-2. [PMID: 8829347] MedlineGoogle Scholar2. Park GJ, Mann SP, Ngu MC. Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum. J Gastroenterol Hepatol. 2001;16:115-7. [PMID: 11206309] CrossrefMedlineGoogle Scholar3. Guigen Y, Xiaoping S, Xinghang M, Mei P, Zhiling Q. Determination of anthraquinones in Polygonum multiflorum and its preparations by magnesium acetate methanol colorimetric method. Zhongcaoyao. 1983;14:255-8. Google Scholar4. European Pharmacopoeia 4th ed. European Directorate for the Quality of Medicines of the Council of Europe. Strasbourg, France 2002. Google Scholar5. Ciprotti M, Giordano R, Ciaralli L, Sepe A, Rossi P, Costantini S. Heavy metals in Ayurvedic preparations: analytical problems and toxicological aspects [Abstract]. 11th International Symposium on Trace Elements in Man and Animals (TEMA 11), Berkeley, California, 2−6 June 2002:74. Google Scholar6. de Witte P, Lemli L. The metabolism of anthranoid laxatives. Hepatogastroenterology. 1990;37:601-5. [PMID: 2289777] MedlineGoogle Scholar7. Tolman KG, Hammar S, Sannella JJ. Possible hepatotoxicity of Doxidan. Ann Intern Med. 1976;84:290-2. [PMID: 1259264] LinkGoogle Scholar8. Beuers U, Spengler U, Pape GR. Hepatitis after chronic abuse of senna [Letter]. Lancet. 1991;337:372-3. [PMID: 1671276] CrossrefMedlineGoogle Scholar9. Streicher E. Acute renal failure and jaundice following rhubarb leaf poisoning. Dtsch Med Wochenschr. 1964;89:2379-81. [PMID: 14225041] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University La Sapienza and Istituto Superiore di Sanità, Rome, Italy. 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