High Prevalence of Antibody to Hepatitis C Virus in Multitransfused Hemophiliacs with Normal Transaminase Levels
Authors: Maria Grazia Rumi, Massimo Colombo, Alessandro Gringeri, Pier Mannuccio Mannucci
Journal: Annals of Internal Medicine (1990)

Brief Reports1 March 1990High Prevalence of Antibody to Hepatitis C Virus in Multitransfused Hemophiliacs with Normal Transaminase LevelsMaria Grazia Rumi, MD, Massimo Colombo, MD, Alessandro Gringeri, MD, Pier Mannuccio Mannucci, MDMaria Grazia Rumi, MD, Massimo Colombo, MD, Alessandro Gringeri, MD, Pier Mannuccio Mannucci, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-5-379 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNon-A, non-B hepatitis is common in hemophiliacs infused with clotting factors concentrates (1, 2). Using serum alanine aminotransferase (ALT) as a surrogate test for diagnosis, the proportion of hemophiliacs with chronic infection varies greatly, ranging from 20% (3) to 77% (4). Accurate estimation of chronic infection may be important clinically, because up to 20% of the patients may develop cirrhosis and hepatocellular carcinoma (5, 6). With the advent of a serologic assay for diagnosing infection with the hepatitis C virus (HCV), the major causative agent of blood-borne non-A, non-B hepatitis (7, 8), the real frequency of chronic infection in hemophiliacs...References1. FletcherTrowellCraskePavierRizza MJJKC. Non-A non-B hepatitis after transfusion of factor VIII in infrequently treated patients. Br Med J. 1983;287:1754-7. CrossrefMedlineGoogle Scholar2. ColomboMannucciCarmelli MPV Transmission of non-A, non-B hepatitis by heat-treated factor VIII concentrates. Lancet. 1985;2:1-6. CrossrefMedlineGoogle Scholar3. CederbaumBlattLevine APP. Abnormal serum transaminase levels in patients with hemophilia A. Arch Intern Med. 1982;142:481-4. CrossrefMedlineGoogle Scholar4. WhiteZeitlerLesesne GKH. Chronic hepatitis in patients with hemophilia A: histologic studies in patients with intermittently abnormal liver function tests. Blood. 1982;60:1259-62. MedlineGoogle Scholar5. DienstagAlter JH. Non-A non-B hepatitis: evolving epidemiologic and clinical perspective. Semin Liv Dis. 1986;6:67-81. CrossrefMedlineGoogle Scholar6. ResnickStoneAntonioli RKD. Primary hepatocellular carcinoma following non-A, non-B posttransfusion hepatitis. Dig Dis Sci. 1983;28:908-11. CrossrefMedlineGoogle Scholar7. ChooKuoWeinerOverbyBradleyHoughton QGALDM. Isolation of a cDNA clone derived from a blood-borne non-A non-B viral hepatitis genome. Science. 1989;244:359-61. CrossrefMedlineGoogle Scholar8. KuoChooAlter GQH An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989;244:362-4. CrossrefMedlineGoogle Scholar9. KuhnlSeidStangelBeyerSihowskiFlik PSWJWH. Antibody to hepatitis C virus in German blood donors [Letter]. Lancet. 1989;2:324. CrossrefMedlineGoogle Scholar10. WeinerKuoBradley AGD Hepatitis C viral (HCV) sequence in the clinical samples from anti-HCV antibody positive and negative individuals with non-A, non-B hepatitis. Lancet. 1990;1:1-3. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the A. Bianchi Bonomi Hemophilia and Thrombosis Center and the University of Milan, Milan, Italy. For current author addresses, see end of text. 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