Atypical Osteomalacia Involving the Axial Skeleton
Authors: BOY FRAME
Journal: Annals of Internal Medicine (1961)

Article1 October 1961Atypical Osteomalacia Involving the Axial SkeletonBOY FRAME, M.D., F.A.C.P., HAROLD M. FROST, M.D., ROBERT S. ORMOND, M.D., ROBERT B. HUNTER, M.D.BOY FRAME, M.D., F.A.C.P.Search for more papers by this author, HAROLD M. FROST, M.D.Search for more papers by this author, ROBERT S. ORMOND, M.D.Search for more papers by this author, ROBERT B. HUNTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-4-632 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThree patients with a unique coarsening and sponge-like appearance in the X rays of the axial skeleton have been observed in the past year. These changes occurred primarily in the cervical spine and to a lesser extent in the lumbar spine, the pelves, and the ribs. The long bones of the appendicular skeleton were not involved. Symptomatology relating to the skeletal system was minimal and the patients were in excellent general health. Histologic study of open iliac crest biopsies demonstrated the presence of an increased number of wide osteoid seams compatible with the diagnosis of osteomalacia in spite of the...References1. SNAPPERNATHAN IDJ: Rickets and osteomalacia. Amer. J. Med. 22: 939, 1957. CrossrefMedlineGoogle Scholar2. COOKEPEENEYHAWKINS WTALCF: Symptoms, signs and diagnostic features of idiopathic steatorrhoea. Quart. J. Med. 22: 59, 1953. MedlineGoogle Scholar3. ROSELUMBDENT GAFHCE: Discussion on generalized aches and pains from metabolic bone disease. Proc. Roy. Soc. Med. 50: 371, 1957. CrossrefMedlineGoogle Scholar4. SNAPPER I: Bone Disease in Medical Practice, Grune & Stratton, New York, 1957, pp. 40-42. Google Scholar5. ALBRIGHTCONSOLAZIOCOOMBSSULKOWITCHTALBOTT FWFFSHSJH: Metabolic studies and therapy in a case of nephrocalcinosis with rickets and dwarfism. Bull. Johns Hopkins Hosp. 66: 7, 1940. Google Scholar6. FOURMAN P: Calcium Metabolism and the Bone, Charles C Thomas, Springfield, 1960, pp. 225-236. Google Scholar7. FRAMESMITH BRW: Phosphate diabetes; case study of osteomalacia. Amer. J. Med. 25: 771, 1958. CrossrefMedlineGoogle Scholar8. FRASER D: Hypophosphatasia. Amer. J. Med. 22: 730, 1957. CrossrefMedlineGoogle Scholar9. FROST HM: Staining of fresh undecalcified, thin bone sections. Stain Techn. 34: 135, 1959. CrossrefMedlineGoogle Scholar10. FROSTVILLANEUVA HMAF: Observations of osteoid seams. Henry Ford Hosp. Med. Bull. 8: 212, 1960. MedlineGoogle Scholar11. HINKELBEILER CLDD: Osteopetrosis in adults. Amer. J. Roentgenol. 74: 46, 1955. Google Scholar12. ALBRIGHTREIFENSTEIN FEC: The Parathyroid Glands and Metabolic Bone Disease, The Williams and Wilkins Co., Baltimore, 1948, pp. 107-113. Google Scholar13. SOBELGOLDFARBKRAMER AEARB: Studies of incurable rickets. II. Role of the "local factor" and of viosterol in the pathogenesis of rickets due to beryllium. J. Biol. Chem. 108: 395, 1935. CrossrefGoogle Scholar14. PINCUSGITTLEMANKRAMER JBIFB: Juvenile osteopetrosis; metabolic studies in two cases and further observations on composition of bones in this disease. Amer. J. Dis. Child. 73: 458, 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BOY FRAME, M.D., F.A.C.P.; HAROLD M. FROST, M.D.; ROBERT S. ORMOND, M.D.; ROBERT B. HUNTER, M.D.Affiliations: Detroit, MichiganReceived for publication September 27, 1960.From the Department of Medicine, Orthopedic Surgery and Radiology, Henry Ford Hospital, Detroit, Mich.Presented at the Forty-second Annual Session of The American College of Physicians, Bal Harbour, Miami Beach, Florida, May 11, 1961.Requests for reprints should be addressed to Boy Frame, M.D., Associate Physician, Division of General Medicine, Henry Ford Hospital, Detroit 2, Mich. 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MICHAEL PARFITT, M.B., B.Chir.Atypical axial osteomalacia. report of four cases with two having features of ankylosing spondylitisAxial osteomalaciaStain Technology a Bone Stain for Osteoid Seams in Fresh, Unembedded, Mineralized BoneFibrogenesis Imperfecta OssiumRecent Progress in Osteomalacia and RicketsA. ROBERT ARNSTEIN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD M. FROST, M.D.The treatment of adult phosphate diabetes and Fanconi syndrome with neutral sodium phosphateA Tetrachrome Stain for Fresh, Mineralized Bone Sections, Useful in the Diagnosis of Bone Diseases 1 October 1961Volume 55, Issue 4Page: 632-639KeywordsBiopsyBoneCalciumDiagnostic radiologyHospital medicineOrthopedic surgeryPhosphatasesRibsSkeletonSpine ePublished: 1 December 2008 Issue Published: 1 October 1961 PDF downloadLoading ...