Ampicillin plus Ceftriaxone for High-Level Aminoglycoside-Resistant <i>Enterococcus faecalis</i> Endocarditis
Authors: Joan Gavaldá, Oscar Len, Benito Almirante, Albert Pahissa
Journal: Annals of Internal Medicine (2008)

Letters5 February 2008Ampicillin plus Ceftriaxone for High-Level Aminoglycoside-Resistant Enterococcus faecalis EndocarditisJoan Gavaldá, MD, PhD, Oscar Len, MD, Benito Almirante, MD, and Albert Pahissa, MDJoan Gavaldá, MD, PhDFrom Hospital Vall d'Hebron, 08035 Barcelona, Spain.Search for more papers by this author, Oscar Len, MDFrom Hospital Vall d'Hebron, 08035 Barcelona, Spain.Search for more papers by this author, Benito Almirante, MDFrom Hospital Vall d'Hebron, 08035 Barcelona, Spain.Search for more papers by this author, and Albert Pahissa, MDFrom Hospital Vall d'Hebron, 08035 Barcelona, Spain.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-3-200802050-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We read with interest the letter by Dr. Singh regarding our article. First, we would like to clarify that the cure rate for HLAR E. faecalis endocarditis was 71.4%, far greater than the best cure rate reached with a cell-wall–susceptible agent alone or in combination with other therapy. After careful review of our article, we found no figure or data that could lead to this confusion. Second, Dr. Singh's question about the synergic effect of ampicillin plus ceftriaxone was evaluated in vitro by Mainardi and colleagues (1) and by our group in different studies in the experimental endocarditis ...References1. Mainardi JL, Gutmann L, Acar JF, Goldstein FW. Synergistic effect of amoxicillin and cefotaxime against Enterococcus faecalis. Antimicrob Agents Chemother. 1995;39:1984-7. [PMID: 8540703] CrossrefMedlineGoogle Scholar2. Gavaldá J, Onrubia PL, Gómez MT, Gomis X, Ramírez JL, Len O, et al. Efficacy of ampicillin combined with ceftriaxone and gentamicin in the treatment of experimental endocarditis due to Enterococcus faecalis with no high-level resistance to aminoglycosides. J Antimicrob Chemother. 2003;52:514-7. [PMID: 12917251] CrossrefMedlineGoogle Scholar3. Gavaldà J, Torres C, Tenorio C, López P, Zaragoza M, Capdevila JA, et al. Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides. Antimicrob Agents Chemother. 1999;43:639-46. [PMID: 10049280] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Joan Gavaldá, MD, PhD; Oscar Len, MD; Benito Almirante, MD; Albert Pahissa, MDAffiliations: From Hospital Vall d'Hebron, 08035 Barcelona, Spain.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIncorporating Quality of Evidence into Decision Analytic Modeling R. Scott Braithwaite , Mark S. Roberts , and Amy C. Justice Brief Communication: Treatment of Enterococcus faecalis Endocarditis with Ampicillin plus Ceftriaxone Joan Gavaldà , Oscar Len , José M. Miró , Patricia Muñoz , Miguel Montejo , Aristides Alarcón , Julián de la Torre-Cisneros , Carmen Peña , Xavier Martínez-Lacasa , Cristina Sarria , Germán Bou , José M. Aguado , Enrique Navas , Joan Romeu , Francesc Marco , Carmen Torres , Pilar Tornos , Ana Planes , Vicenç Falcó , Benito Almirante , and Albert Pahissa Ampicillin plus Ceftriaxone for High-Level Aminoglycoside-Resistant Enterococcus faecalis Endocarditis Akashdeep Singh Metrics 5 February 2008Volume 148, Issue 3Page: 243KeywordsAttentionCell wallsConflicts of interestEndocarditisEnterococcus faecalisProteins ePublished: 5 February 2008 Issue Published: 5 February 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...