tbuckley/cabot-search huggingface dataset:
Two Rare Growths of the Soft Palate
Authors: C. Ellerman
Journal: BMJ (1888)

in bed, and for three months after that a Sayer's jacket was kept on; she went on favourably in every way, and not only was the Potts' spine cured, with, of course, derormity, but the abscess became eventually absorbed.I examined her with the greatest care on June 21st last, and the following state of things was observed: Her appearance was healthy, though not entirely free from wear and tear ; her pulse, tem.perature, and respiration wero natural; a fulnes, which when first seen had existed in the left lliac fossa, had entirely disappeared.No trace whatever of the abscess could be found on palpation, or other- wise.A severe pain in the spine, from which she had also on the occasion of my first seeiDg her sutfered, had likewise disppeared.There was some little pain across the hiips after sitting, and the left leg was weaker than the right; the bowels were moved every second day.The
Drug Resistance in Cancer Therapy: Cancer Treatment and Research Series
Authors: M. ROTHENBERG
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Drug Resistance in Cancer Therapy: Cancer Treatment and Research Series Get access Robert F. Ozols , ed. Boston : Kluwer Academic Publishers , 1989 , 210 pp. $92.50. MACE ROTHENBERG MACE ROTHENBERG Division of Cancer TreatmentNational Cancer Institute Buldg. 31, Rm. 3A49, Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 8, 18 April 1990, Page 710, https://doi.org/10.1093/jnci/82.8.710 Published: 18 April 1990
A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms.
Authors: S Kontusaari, G Tromp, H Kuivaniemi, A M Romanic, D J Prockop
Journal: Journal of Clinical Investigation (1990)

Experiments were carried out to test the hypothesis that familial aortic aneurysms, either thoracic or abdominal, are caused by mutations in the gene for type III procollagen (COL3A1) similar to mutations in the same gene that have been shown to cause rupture of aorta and other disastrous consequences in the rare genetic disorder known as Ehlers-Danlos syndrome type IV. A family was identified through a 37-yr-old female captain in the United States Air Force who was scrutinized only because many of her direct blood relatives had died of ruptured aortic aneurysms. The woman was heterozygous for a single-base mutation that converted the codon for glycine 619 of the alpha 1(III) chain of type III procollagen to a codon for arginine. Studies on cultured skin fibroblasts demonstrated the mutation caused synthesis of type III procollagen that had a decreased temperature for thermal unfolding of the protein. The same mutation was identified in DNA extracted from pathologic specimens from her mother who had died at the age of 34 and a maternal aunt who died at the age of 55 of aortic aneurysms. Examination of DNA from samples of saliva revealed that the woman's daughter, her son, a brother, and an aunt also had the mutation. The results demonstrated that mutations in the type III procollagen gene can cause familial aortic aneurysms and that DNA tests for such mutations can identify individuals at risk for aneurysms.
Malignant Pulmonary Artery Hypertension in Rheumatic Mitral Valvular Disease.
Authors: Albert G. Vitale
Journal: Annals of Internal Medicine (1965)

s1 November 1965Malignant Pulmonary Artery Hypertension in Rheumatic Mitral Valvular Disease.Albert G. Vitale, M.D., John L. Soscia, M.D.Albert G. Vitale, M.D.Search for more papers by this author, John L. Soscia, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-905_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptApproximately 12% of patients with symptomatic rheumatic mitral valvular disease present with pulmonary artery pressure or pulmonary vascular resistance values approximating those found at the systemic level. This group of patients exhibits a rather remarkable clinicial syndrome that we have called "malignant pulmonary artery hypertension" in mitral valvular disease. A detailed analysis of the natural history, physical findings, physiologic, and radiologic data are presented on ten patients with this syndrome.All patients had either a pulmonary systolic pre ssure of 100 mm Hg or a pulmonary arteriolar resistance of 800 dynes/sec/cm-5or greater at rest. The highest values recorded were 192/63... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 905-905KeywordsHypertensionPulmonary arteriesPulmonary hypertensionPulmonary vascular resistanceValvular diseases Issue Published: 1 November 1965 PDF DownloadLoading ...
Involvement of programmed cell death in preimplantation embryo demise
Authors: A Jurisicova
Journal: Human Reproduction Update (1995)

Journal Article Involvement of programmed cell death in preimplantation embryo demise Get access A. Jurisicova, A. Jurisicova 1Division of Reproductive Sciences, The Toronto Hospital Research InstituteToronto, M5G lL72Department of Zoology, University of TorontoToronto, M5S l A l Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Varmuza, S. Varmuza 2Department of Zoology, University of TorontoToronto, M5S l A l Search for other works by this author on: Oxford Academic PubMed Google Scholar R.F. Casper R.F. Casper 4 1Division of Reproductive Sciences, The Toronto Hospital Research InstituteToronto, M5G lL73Department of Obstetrics and Gynecology, University of TorontoM5G 2C4, Canada 4 To Whom correspondence should be addressed at:6–246 EN. The Toronto Hospital. 200 Elizabeth St. Tomnto. Ortario M5G 2C4. Cannda. Fax: (416) 340–4022: e-mail: r.easpar@utoronto.ca. Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction Update, Volume 1, Issue 6, 1 January 1995, Pages 558–566, https://doi.org/10.1093/humupd/1.6.558 Published: 01 November 1995 Article history Received: 06 August 1995 Accepted: 06 August 1995 Published: 01 November 1995
The Influence of Malarious Disorders on Urethral Fever, with Remarks on the Treatment of Stricture
Authors: J. W. Cousins
Journal: BMJ (1884)

DIuiSoN the recenlt debate oni urethral fever in the Medical Society of bondon, the President (Sir Joseph Fayrer), referred to the asso- ciation which frequently exists between urethral fever and the paroxysmal 'fevers of malarious climates.He remarked "that the disease is uniformnly mnore severe, and more probable to occur in malarious climates than in our comparatively temperate one;" aud that "persons who have been under the influence of malaria,
Hypertension and Renal Disease-Reply
Authors: Robert F. Maronde
Journal: JAMA (1976)

<h3>In Reply.—</h3> At least four of the six references cited by Dr Rubinoff relate to malignant nephrosclerosis. This is an<i>acute</i>entity that, if not arrested, leads to irreversible renal disease, and vigorous treatment is indicated. Our article states this clearly. In regard to chronic renal failure as the result of benign nephrosclerosis, there is no evidence that long-term "vigorous" treatment of hypertension reverses or even prevents progression of this. Nevertheless, we treat such patients, but at least initially, we do not lower the diastolic pressure below 100 to 105 mm Hg. This allows for hemodynamic adjustments and tends to minimize the chances of clinical uremia developing. More vigorous treatment, on a long-term basis, is left to the judgement of the physician and the tolerance of treatment by the patient.
Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III
Authors: David B. Simon, Ranjit S. Bindra, Traci A. Mansfield, Carol Nelson-Williams, Erica Mendonca, Rosário Stone, Scott Schurman, Ahmet Nayir, Harika Alpay, Aysin Bakkaloglu, Juan Rodriguez-Soriano, Jose M. Morales, Sami A. Sanjad, C. Mark Taylor, Daniela Pilz, Andrew Brem, Howard Trachtman, William Griswold, George A. Richard, Eunice John, Richard P. Lifton
Journal: Nature Genetics (1997)
Plasma Homocysteine Levels in Type 1 Diabetic Patients
Authors: Carlos Pavía, Imma Ferrer, Carme Valls, Rafael Artuch, Catrina Colomé, M. Antònia Vilaseca
Journal: Diabetes Care (2001)

We appreciate the comments of Cotellessa et al. (1) as well as their interest in our work. We agree on their results, which confirm our findings. In patients with type 1 diabetes, in the absence of serious complications, the plasmatic concentration of homocysteine is in the low range of the reference values for age-matched control subjects. For this reason, it …
Use of Biplane Cinefluorography for Measurement of Ventricular Volume
Authors: CARLETON B. CHAPMAN, ORLAND BAKER, JACK REYNOLDS, FREDERICK J. BONTE
Journal: Circulation (1958)

A biplane cinefluorographic technic for measuring ventricular volume is described and its accuracy and limitations are assessed. Although rather complicated and time-consuming at present, the method permits construction of volume curves and estimation of stroke volume of the left ventricle for several successive contractions in the intact animal or man. This method may prove most useful for physiologic research and ultimately for diagnostic purposes.
American Heart Association Guidelines for Primary Prevention of Atherosclerotic Cardiovascular Disease Beginning in Childhood
Authors: Rae-Ellen W. Kavey, Stephen R. Daniels, Ronald M. Lauer, Dianne L. Atkins, Laura L. Hayman, Kathryn Taubert
Journal: Circulation (2003)

HomeCirculationVol. 107, No. 11American Heart Association Guidelines for Primary Prevention of Atherosclerotic Cardiovascular Disease Beginning in Childhood
Successful Treatment of Severe Refractory Sulfonylurea-Induced Hypoglycemia With Octreotide
Authors: Andrew J Krentz, Patrick J Boyle, Keith M Justice, Alex D Wright, David S Schade
Journal: Diabetes Care (1993)

Objective— To test the clinical use of octreotide in the treatment of sulfonylurea-induced hypoglycemia. Research Design and Methods— A case is reported of sulfonylurea-induced hypoglycemic coma in a nondiabetic subject, which was complicated by relapse of hypoglycemia after resuscitation with intravenous dextrose. Subcutaneous octreotide, 50 μg 12 hourly, suppressed stimulated endogenous insulin secretion, thereby preventing a further recurrence of hypoglycemia. Results— No adverse effects of treatment were observed. Conclusions— These results suggest a significant role for octreotide as an adjunct to intravenous dextrose in the management of severe and refractory cases of sulfonylurea-induced hypoglycemia.
Clinical significance of human hepatocyte growth factor in blood from patients with fulminant hepatic failure
Authors: Hirohito Tsubouchi, Shuichi Hirono, Eiichi Gohda, Hiroyuki Nakayama, Kozo Takahashi, Osami Sakiyama, Hiroomi Miyazaki, Junichi Sugihara, Eiichi Tomita, Yasutoshi Muto, Yasushi Daikuhara, Shuji Hashimoto
Journal: Hepatology (1989)

We have recently found the presence of human hepa-tocyte growth factor in sera of patients with fulminant hepatic failure and have purified human hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. In this paper, we report the clinical significance of human hepatocyte growth factor in blood from patients with fulminant hepatic failure. The effect of sera or plasma from 17 patients with fulminant he-patic failure on liver cell growth was examined by use of adult rat hepatocytes in primary culture. Sera or plasma from 16 of the 17 patients with fulminant he-patic failure stimulated DNA synthesis in hepatocytes more effectively than normal human serum. The mean growth-promoting activity for the 17 patients with fulminant hepatic failure was about 16 times higher than that obtained for normal human serum. This growth-promoting activity of the patients'blood was not related to sex, age, clinical outcome of the patients or type of fulminant hepatic failure, but was intimately related to the clinical grade of hepatic coma. Sera or plasma with Grade III and IV coma showed stimulatory activity on DNA synthesis more markedly than sera or plasma from patients with coma of less than Grade II. In the surviving group, this activity decreased as the hepatic coma of patients improved. In fact, this activity of sera from patients at the recovery stage showed no significant increase compared with that of normal human serum. In the group of terminal patients, this activity increased as the coma developed. These results suggest that human hepatocyte growth factor in blood from patients with fulminant hepatic failure is a physiological hepato-trophic factor and plays an important role in liver regeneration of patients.
US cancer care system in "highly volatile state," cancer group says
Authors: M. McCarthy
Journal: BMJ (2015)

The US cancer care system is in a “highly volatile state” because of growing demand, soaring costs, and changing models of healthcare delivery, a new report from the American Society of Clinical Oncology has said.1

The report found that care of patients with cancer has made great advances in the United States in recent years, with more than two thirds of patients (68.5%) now living beyond five years of diagnosis, up from just under half (49%) in 1975. But it said that the nation’s cancer care system was coming under increasing stress as demand for services outstripped the growth in the …
Varieties of Healing
Authors: Linda L. Barnes
Journal: Annals of Internal Medicine (2002)

Letters6 August 2002Varieties of HealingLinda L. Barnes, MTS, MA, PhDLinda L. Barnes, MTS, MA, PhDBoston University School of Medicine; Boston, MA 02118Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-3-200208060-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Kaptchuk and Eisenberg introduce a compelling taxonomy of unconventional healing practices (1). I invite them to pursue their recognition that medical practices of “ethnic communities” are defined as ethno-medicine, while unconventional practices of “mainstream white Americans” are classified as complementary and alternative medicine (CAM). The authors acknowledge that existing tendencies reflect “stubborn racist prejudices,” but their taxonomy risks inadvertently perpetuating these through use of the term parochial.The authors characterize parochial systems as those confined to specific ethnic or religious groups. But ethnic boundaries are no longer self-contained. The convergence of minority communities in urban centers encourages ...Reference1. Kaptchuk TJ, Eisenberg DM. Varieties of healing. 2: a taxonomy of unconventional healing practices. Ann Intern Med. 2001;135:196-204. [PMID: 11487487] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Linda L. Barnes, MTS, MA, PhDAffiliations: Boston University School of Medicine; Boston, MA 02118 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoVarieties of Healing. 1: Medical Pluralism in the United States Ted J. Kaptchuk and David M. Eisenberg Varieties of Healing. 2: A Taxonomy of Unconventional Healing Practices Ted J. Kaptchuk and David M. Eisenberg Varieties of Healing Ted J. Kaptchuk and David M. Eisenberg Varieties of Healing Donald A. Sandweiss Metrics 6 August 2002Volume 137, Issue 3Page: 217-218KeywordsArthritisComplementary and alternative medicineExerciseFood ePublished: 6 August 2002 Issue Published: 6 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
BRIEF PSYCHOTHERAPY WITH ENURETICS IN THE ARMY
Authors: GEORGE KRIEGMAN, HARLAN B. WRIGHT
Journal: American Journal of Psychiatry (1947)

This study represents the results of brief psychotherapy in 25 enuretics seen in the Mental Hygiene Consultation Service, Camp Lee, Virginia. There were 16 cases in which the treatment was considered successful; 4 cases showed improvement; and 5 cases were therapeutic failures. The therapeutic plan was conceived in a definite and uniform manner so that almost identical explanations and emotional approaches were used in all cases. Enuresis was regarded as an immature behavior pattern, indicating that the patient lacked an emotionally satisfactory and appropriate relationship to significant adults. A therapeutic situation was created in which the patient's emotional needs could be worked out and satisfied, thus permitting him to develop maturity and independence. As a result the enuresis disappeared. At first there was no attempt to have the patient become fully aware of his interpersonal relationships; instead, he was allowed to work them out in the therapeutic setting. The therapist assumed the role of the significant parental figure. To these immature, dependent individuals the army regime at first was an overwhelming, frightening experience wherein they were unable to turn to their lifelong emotional supports. The parental role of the therapist therefore became magnified. The aid given in easing the patient's training schedule or in modifying his burden in the Army increased his feeling of attachment. Although this program proved successful in the military setting, it is doubtful that it can be applied unmodified to civilian practice where the degree of control over the patient's daily life is not as great and where the patient can continue to maintain his usual sources of emotional supports.
Oxidant stress during reperfusion of ischemic liver: No evidence for a role of xanthine oxidase
Authors: Jacques Metzger, Srinath P. Dore, Bernhard H. Lauterburg
Journal: Hepatology (1988)

Oxygen-derived free radicals might play a role in the injury produced by reperfusion of ischemic organs. Since the generation of reactive oxygen species results in an increased formation of glutathione disulfide, we have attempted to document an oxidant stress during reperfusion of ischemic liver by following the hepatic production of glutathione disulfide in vivo and in the perfused rat liver. Following partial hepatic ischemia of 120 min duration, the plasma concentration of glutathione disulfide gradually increased from 0.8 ± 0.1 to 9.1 ± 1.6 μ M (mean ± S.E., n = 6) after 1 hr of reperfusion. The plasma concentration of reduced glutathione increased only 2-fold from 21.4 ± 2.4 to 38.1 ± 3.4 μ M . The rise in plasma glutathione disulfide was higher with increasing duration of ischemia from 30 to 120 min and was associated with a gradual increase in hepatic glutathione disulfide. The hepatic origin of glutathione disulfide was documented in the perfused rat liver where the release of glutathione disulfide increased gradually during reperfusion following 90 min of warm ischemia from 1.0 ± 0.1 to 2.6 ± 0.5 nmole per min per gm liver at 30 min after onset of reperfusion. The administration of allopurinol, an inhibitor of xanthine oxidase, did not decrease the release of glutathione disulfide (29.9 ± 3.8 nmoles per gm in controls vs. 44.7 ± 10.0 nmoles per gm in 30 min with allopurinol) and ALT (3.3 ± 1.4 units per gm in controls vs. 2.6 ± 0.8 units per gm in 30 min with allopurinol). Our studies document an oxidant stress associated with reperfusion of ischemic liver. The absent effect of allopurinol and the observation that the oxidant stress is not maximal when the available concentration of substrates for xanthine oxidase is highest (i.e., at the onset of reperfusion) indicate that the oxidant stress may not be due to the generation of superoxide anion radicals by xanthine oxidase, but rather may result from the activation of leukocytes and resident macrophages.
Sedation for upper gastrointestinal endoscopy: results of a nationwide survey.
Authors: T K Daneshmend, G D Bell, R F Logan
Journal: Gut (1991)

A postal questionnaire inquiring about routine sedation and premedication practice for upper gastrointestinal endoscopy was sent to 1048 doctors. Of 665 appropriate returns, 81% were from consultant physicians and surgeons. Most endoscopists (90%) reported using an intravenous benzodiazepine for at least three quarters of endoscopies and 54% of physicians and 69% of surgeons always did so. Midazolam was the intravenous sedative used by a third of all respondents and 13% also used an additional intravenous agent, usually pethidine. Over the previous two years a total of 119 respiratory arrests, 37 cardiac arrests, and 52 deaths were identified. Adverse outcomes were reported more frequently by consultant physicians, by those who 'titrated' the intravenous sedative, and by those who used an additional intravenous agent, but were reported equally frequently by endoscopists using midazolam and endoscopists using diazepam. There is an urgent need for a prospective study to identify the circumstances and risk factors associated with adverse outcomes related to endoscopy.
Catholic Medical Ethics
Authors: Lyle C. Voge
Journal: JAMA (1962)

<h3>To the Editor:—</h3> In regard to your editorial of June 9 entitled "Catholic Medical Ethics" (<i>JAMA</i><b>180</b>:834, 1962), I would like to refer you to part of an article appearing in<i>Modern Moral Problems</i>(Conway, J.D.: Therapeutic Abortion, Notre Dame, Ind.: Fides Publishers Association, 1961, p. 63). The Catholic doctor should discard his caduceus if he does a bit less than he rightly can to save this mother. He would be trying to play the part of God if he were to decide that she should die, even to save a thousand babies. But he would be playing God with equal presumption if he were to decide that her baby must die, and then personally see that it does. A doctor may not do murder even to save life, no matter how precious the life. It may happen that the doctor will decide in desperation that he simply cannot
The Medicare Physician-Data Release — Context and Rationale
Authors: Niall Brennan, Patrick H. Conway, Marilyn Tavenner
Journal: New England Journal of Medicine (2014)

Believing that greater transparency can help drive health improvement and delivery of higher-quality, lower-cost care, the Centers for Medicare and Medicaid Services has released information on utilization by more than 880,000 clinicians who care for Medicare patients.
THE CHEMISTRY OF THE MEDICAL SCHOOL.
Authors: J. H. LONG
Journal: JAMA (1904)

In the present condition of rapid growth and devel opment in our medical schools, one of the vexing problems which has come up for solution is with reference to the kind and amount of chemistry which should be taught. It is evident to any one who takes the trouble to look that the methods and concepts of somewhat advanced chemistry are becoming more and more the property of the real medical worker, and to-day we hear from the clinician terms which but a few years ago were heard only in the laboratory of the investigator in pure chemistry. Beyond question, the medical man is called on to learn more chemistry and, seemingly, a new kind of chemistry. Not long ago, in response to the question as to the kind of chemistry which should be taught to medical students, it would have been thought sufficient to answer "medical chemistry,"
Three-dimensional cell aggregates composed of HUVECs and cbMSCs for therapeutic neovascularization in a mouse model of hindlimb ischemia
Authors: Ding-Yuan Chen, Hao-Ji Wei, Kun-Ju Lin, Chieh-Cheng Huang, Chung-Chi Wang, Cheng-Tse Wu, Ko-Ting Chao, Ko-Jie Chen, Yen Chang, Hsing-Wen Sung
Journal: Biomaterials (2012)