Clinical Experience with Vincaleukoblastine in Far-advanced Hodgkin's Disease and Various Malignant States
Authors: JOHN W. FROST
Journal: Annals of Internal Medicine (1962)

Article1 June 1962Clinical Experience with Vincaleukoblastine in Far-advanced Hodgkin's Disease and Various Malignant StatesJOHN W. FROST, M.D., F.A.C.P., MANFRED I. GOLDWEIN, M.D., JAMES A. BRYAN, M.D.JOHN W. FROST, M.D., F.A.C.P.Search for more papers by this author, MANFRED I. GOLDWEIN, M.D.Search for more papers by this author, JAMES A. BRYAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-6-854 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVincaleukoblastine or vinblastine sulfate (VLB) is a recent addition to the chemotherapy of malignant disease. Unlike most of the older drugs of proven benefit, which are either alkylating agents or compounds acting in competitive inhibition with purines and pyrimidines, this agent is an alkaloid whose chemical mode of action may well prove to be different. Earlier reports have shown it to have a favorable effect in Hodgkin's disease (1, 2) and in metastatic choriocarcinoma (3). While some effects in metastatic cancers of other types have been described, these were transient.The drug is extracted from the common flowering shrub, the...References1. WARWICKDARTEBROWN OHJMTC: Some biological effects of vincaleukoblastine, an alkaloid from Vinca rosea linn in patients with malignant disease. Cancer Res. 20: 1032, 1960. MedlineGoogle Scholar2. HODESROHNBOND MERJWH: Vincaleukoblastine. I. Preliminary clinical studies. Cancer Res. 20: 1041, 1960. MedlineGoogle Scholar3. HERTZLIPSETTMOY RMBRN: Effect of Vincaleukoblastine on metastatic choriocarcinoma and related trophoblastic tumors in women. Cancer Res. 20: 1050, 1960. MedlineGoogle Scholar4. KOBLEBEERCUTLS RLCTJH: Role of chance observations in chemotherapy: Vinca Rosea, Ann. N. Y. Acad. Sci. 76: 882, 1958. CrossrefMedlineGoogle Scholar5. JOHNSONWRIGHTSVOBODAVLANTIES ISHFGHJ: Antitumor principles derived from Vinca Rosea Linn. I. Vincaleukoblastine and Leurosine. Cancer Res. 20: 1016, 1960. MedlineGoogle Scholar6. GORMANNEUSSSVOBODA MNGH: Vinca alkaloids. IV. Structural features of leurosine and vincaleukoblastine. Representatives of a new type of indole-indoline alkaloids. J. Amer. Chem. Soc. 81: 4745, 1959. CrossrefGoogle Scholar7. Collected experience as reported in company Publication 00351 I, February, 1961. Eli Lilly and Company, Indianapolis, Indiana. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN W. FROST, M.D., F.A.C.P.; MANFRED I. GOLDWEIN, M.D.; JAMES A. BRYAN, M.D.Affiliations: Philadelphia, PennsylvaniaFrom the Hematology Section, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.Dr. Bryan is a Fellow of the American Cancer Society.Requests for reprints should be addressed to John W. Frost, M.D., Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia 4, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCommentary on and reprint of DeVita VT Jr, Serpick AA, Carbone PP, Combination chemotherapy in the treatment of advanced Hodgkin's disease, in Annals of Internal Medicine (1970) 73:881–895Mucocutaneous side effects of cancer chemotherapyToxicity of Chemotherapeutic AgentsDie LymphogranulomatoseCurrent cancer chemotherapy in obstetrics and gynecologyChemotherapy of the LymphomasCombination Chemotherapy in the Treatment of Advanced Hodgkin's DiseaseVINCENT T. DEVITA JR., M.D., F.A.C.P., ARTHUR A. SERPICK, M.D., F.A.C.P., PAUL P. CARBONE, M.D.VinblastineLangzeitbehandlung der fortgeschrittenen Lymphogranulomatose mit Vinblastin-SulfatBiological Activity of the Terpenoids and Their Derivatives — Recent AdvancesVinblastine in the treatment of advanced Hodgkin's diseaseVinblastine VS. nitrogen mustard therapy of Hodgkin's diseaseVINCA ROSEA ALKALOIDSChemotherapy of Hodgkin's diseaseTreatment of neoplastic diseases with an improved oral preparation of vinblastine sulfateA Methylhydrazine Derivative in Hodgkin's Disease and Other Malignant Neoplasms Therapeutic and Toxic Effects Studied in 51 PatientsKURT W. BRUNNER, M.D., CHARLES W. YOUNG, M.D.The Chemotherapy of Malignant DiseaseVinblastine Sulfate in Hodgkin's Disease in PregnancyARNOLD I. ROSENZWEIG, QUINTOUS E. CREWS JR., HERBERT G. HOPWOODHodgkin's Disease — Prognosis, Treatment and Etiologic and Immunologic ConsiderationsPharmakognosie 1 June 1962Volume 56, Issue 6Page: 854-859KeywordsAlkaloidsChemotherapyDrugsHematology and oncologyHemoglobinHodgkin lymphomaPancreasPurinesSarcomaSulfates ePublished: 1 December 2008 Issue Published: 1 June 1962 PDF downloadLoading ...