tbuckley/cabot-search huggingface dataset:
DOES LONGTERM ENDURANCE RUNNING ENHANCE OR INHIBIT CORONARY ARTERY PLAQUE FORMATION? A PROSPECTIVE MULTIDETECTOR CTA STUDY OF MEN COMPLETING MARATHONS FOR LEAST 25 CONSECUTIVE YEARS
Authors: Jonathan G. Schwartz, Stacia Merkel-Kraus, Sue Duval, Kevin Harris, Gretchen Peichel, John R. Lesser, Thomas Knickelbine, Bjorn Flygenring, Terry R. Longe, Catherine Pastorius, William R. Roberts, Stephen C. Oesterle, Robert S. Schwartz
Journal: Journal of the American College of Cardiology (2010)
Congenital Absence of Apolipoprotein E and Neurological Function
Authors: Daniel T. Laskowitz, Dawn N. Kernagis
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
THE PATHOLOGY OF MASTOIDITIS AS REVEALED BY THE X-RAY
Authors: SIDNEY LANGE
Journal: JAMA (1910)

Thex-ray study of the mastoid region, which was begun in March, 1908, has undergone a slow but gratifying metamorphosis. Undertaken with grave doubts as its practical value, it has developed into a method which rivals in its accuracy other recognized methods of physical examination.  At the inception of the work, it promised at best to show the anatomy and the grosser chronic changes in the mastoid region. Then the graver acute changes were registered on the skiagram, and later it was found that the milder acute mastoid affections yielded roentgenologic evidence of their presence. Within the last few months it was discovered that in acute otitis media without clinical signs of mastoid involvement, thex-ray cells just often show clouding and filling up of the mastoid cells just back of the antrum, which changes may either
Abstract 3285: Phenotypic characterization of circulating tumor cells (CTCs) in triple negative breast cancer patients
Authors: Galatea Kallergi, Sofia Agelaki, Argyri Mathioudaki, Dimitris Mavroudis, Vassilis Georgoulias
Journal: Cancer Research (2010)

Abstract Background: Molecular classification of breast cancer revealed that there are five different subtypes related to clinical outcome:. luminal A, luminal B, normal-like, ERBB2-positive and basal-like. Triple negative patients (ER-negative, PR-negative, HER2-negative) belong to the basal-like subtype. Their tumors commonly express EGFR and are associated with poor prognosis. Circulating Tumor Cells (CTCs) have been proposed as a “real time liquid biopsy” in breast cancer patients. CTCs are associated with disease relapse and could serve as a target for molecular cancer therapies. The aim of the present study was, for the first time, the phenotypic characterization of CTCs in triple negative breast cancer patients. Methods: We evaluated peripheral blood mononuclear cells (PBMC) cytospins from 40 triple negative patients and found CTCs in thirty one of them (15 early and 16 metastatic). The expression of Cytokeratins (CK), Estrogens Receptor (ER), Progesterone Receptor (PR), Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER2) in CTCs was assessed using double immunofluorescent staining and confocal laser scanning microscopy and the Ariol system. PBMCs were stained with a monoclonal A45-B/B3 pancytokeratin antibody in combination with ER, PR, EGFR or HER2 antibodies, respectively. Results: Our results demonstrated that ER, PR, EGFR and HER2 were expressed in 58%, 45%, 55% and 58% of the examined CK-positive patients. The respective proportions for early versus (vs) metastatic patients were 67% vs 50% for ER, 53% vs 38% for PR, 60% vs 44% for EGFR and 60% vs 56% for HER2. In addition ER, PR, EGFR and HER2 were expressed in 5.6%, 79.7%, 80.7% and 13.4%, respectively, of the total examined CTCs. Triple staining experiments with the Ariol system revealed no co-expression of CK/EGFR/ER in CTCs; however, there was only one patient with CTCs co-expressing CK/HER2/ER. Conclusions: ER is expressed but in a minority of CTCs in triple negative breast cancer patients though the majority of CTCs revealed expression of PR and EGFR. However the clinical significance of these findings remain unknown and need further evaluation. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3285.
A chimeric GB virus B with 5′ nontranslated RNA sequence from hepatitis C virus causes hepatitis in tamarins
Authors: Rene Rijnbrand, Yan Yang, Lucy Beales, Francis Bodola, Kathryn Goettge, Lisette Cohen, Robert E. Lanford, Stanley M. Lemon, Annette Martin
Journal: Hepatology (2005)

Only humans and chimpanzees are fully permissive for replication of hepatitis C virus (HCV), an important cause of liver cirrhosis and cancer worldwide. The absence of suitable animal models limits opportunities for in vivo evaluation of candidate hepatitis C therapeutics and slows progress in the field. Here, we describe a chimeric virus derived from GB virus B (GBV-B), an unclassified hepatotropic member of the family Flaviviridae that is closely related to HCV and infects tamarins (Saguinus sp.), in which a functionally important HCV regulatory sequence replaced an analogous sequence in the 5′ nontranslated region (5′NTR) of the GBV-B genome. The transplanted sequence comprised domain III of the internal ribosome entry site (IRES), which directly binds the 40S ribosome subunit and is a target for candidate therapeutics. The chimeric 5′NTR retained ribosome binding activity and was competent in directing protein translation both in cell-free translation reactions and in transfected primary tamarin hepatocyte cultures. Virus rescued from the chimeric RNA replicated in the liver of tamarins, causing biochemical and histopathological changes typical of viral hepatitis. However, adaptive mutations were required elsewhere in the genome for efficient replication. Virus was not rescued from other, translationally competent, chimeric RNAs in which domain II of the IRES was exchanged. Thus, the 5′NTR appears to contain virus-specific replication signals that interact with other sites within the viral genome or with viral proteins. In conclusion, such novel chimeric flaviviruses offer opportunities for new insights into HCV replication mechanisms, while potentially facilitating the evaluation of candidate therapeutics in vivo. Supplementary material for this article can be found on the HEPATOLOGY website http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html. (HEPATOLOGY 2005.)
The Pharmacopeia of the United States of America
Authors: John R. Lewis
Journal: JAMA (1970)

<i>USP XVIII</i>, the second revision of the Pharmacopeia produced by the 1969-1970 General Committee on Revision, has recently become available and will become official from Sept 1, 1970. This revision contains 1,103 monographs, including 257 newly recognized articles. Only 58 previously recognized articles were dropped from this edition. The Subcommittee on Scope has given broader recognition than previously to individual drugs in a class, and thus more articles of equal therapeutic merit are included; nevertheless, the result is more apparent in some groups than in others; for example, only one thiazide diuretic was recognized for admission. The recognition of fixed combination of drugs is still very limited; none of the oral contraceptives is admitted, although most of their individual components are included. The section on "General Information and Procedures," which is useful primarily to those testing drugs, comprises about 20% of the pages. The<i>USP</i>procedures for drug testing reflect
Chemical Pathology of Huntington's Disease
Authors: E D Bird
Journal: The Annual Review of Pharmacology and Toxicology (1980)

Huntington's disease (HD), a dominantly inherited disorder of the nervous system, is usually manifest about middle age by dance-like movements. The disorder may occur in children, when epilepsy and rigidity may be the predominant signs. Degeneration of neurons occurs throughout the whole brain, but this is most marked in the basal ganglia. Neurochemical examination of postmortem brain frozen at the time of autopsy has been collected from patients dying with HD and compared with postmortem brain from psychotic patients and cases without neuropsychiatric disease. A number of alterations in neurotransmitters and their biosynthetic enzymes have been found. There are decreased concentrations of the neuroinhibitory transmitter gamma aminobutyric acid and this is associated with increased concentrations of dopamine and serotonin in the basal ganglia. In addition, there is decreased activity of glutamic acid decarboxylase, choline acetyltransferase, angiotensin-converting enzyme, as well as a decreased concentration of the neuropeptide substance P. Various pharmacologic agents have been tried based on the neurochemical alterations, but nothing has been found to be superior to the various neuroleptics in common use.
Cutaneous tuberculosis in an immunocompromised host: an unusual clinical presentation
Authors: A.E.M. Taylor, P.A. Corris
Journal: British Journal of Dermatology (1995)

Journal Article Cutaneous tuberculosis in an immunocompromised host: an unusual clinical presentation Get access A.E.M. Taylor, A.E.M. Taylor Department of Dermatology Royal Victoria Infirmary Search for other works by this author on: Oxford Academic Google Scholar P.A. Corris P.A. Corris Department of Cardiothoracic Medicine, Freeman Hospital, Newcastle upon Tyne, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 1, 1 January 1995, Pages 155–156, https://doi.org/10.1111/j.1365-2133.1995.tb08647.x Published: 01 January 1995
THE INACTIVATION OF BIOLOGICALLY ACTIVE PROTEINS, AND THE VIRUS OF WESTERN EQUINE ENCEPHALOMYELITIS BY PERIODIC ACID
Authors: Walther F. Goebel, Peter K. Olitsky, Arturo C. Saenz
Journal: The Journal of Experimental Medicine (1948)

The action of periodic acid on two biologically active proteins, crystalline ribonuclease and pneumococcus Type III immune globulin, and on the virus of Western equine encephalomyelitis has been studied. The biological activity of the two proteins and the pathogenic action of the virus were destroyed by the reagent; the specific antigenicity of the immune globulin was retained, however, but that of the equine virus was lost. The bearing of these reactions on the chemical alteration of the respective substances has been discussed.
REDUCING THE COST OF TAVR: AN EVALUATION OF THE IMPACT OF LENGTH OF STAY ON THE COST OF TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Christopher Meduri, Brian Potter, Ruben L.J. Osnabrugge, Philippe Genereux, Andreas Ruck, Vivek Rajagopal, David Wood, A. Kappetein, David Cohen
Journal: Journal of the American College of Cardiology (2014)
The uptake of etiocholanolone by human bone marrow immature granulocytes
Authors: José J. Minguell, S. Lee, R. E. Helmer, F. H. Gardner
Journal: American Journal of Hematology (1982)

Abstract A cell fraction enriched in immature granulocytes was obtained after fractionation of human bone marrow by a three‐step procedure. This fraction sediments at an average density of 1.073 and has a high content of myelocytes and metamyelocytes. It showed the highest specific uptake of etiocholanolone when compared to other bone marrow cell fractions. Autoradiographic studies demonstrated a higher number of silver grains over myelocytes and metamyelocytes than in other cell types. These results suggest the presence in human bone marrow of a target cell for etiocholanolone, located in the late mitotic or postmitotic pool or granulocytes.
Basics of Blood Management
Authors: Joseph H. McIsaac
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obstetric emergencies
Authors: Geoffrey Chamberlain, Philip Steer
Journal: BMJ (1999)

The management of emergencies is usually the responsibility of hospital obstetricians. As more maternity care is now given in the community, however, midwives, general practitioners, and paramedics may be involved and must know the outlines of management of emergencies and the possible side effects. If such a situation occurs outside the hospital then arrangements must be made to transport the woman to the obstetric unit safely and promptly. The first principles of dealing with obstetric emergencies are the same as for any emergency (see to the airway, breathing, and circulation), but remember that in obstetrics there are two patients; the fetus is very vulnerable to maternal hypoxia ### Clinical features of abruption of the placenta Symptoms Signs All emergency protocols should have been considered beforehand and mutually agreed by obstetricians, midwives, general practitioners, and paramedics. Everybody then knows their immediate priority, and hazards to the woman can be minimised. An abruption is a death threat to the fetus and a hazard to the mother. When the placenta separates from its bed (probably because of the rupture of a malformed blood vessel), the damage to the fetus follows not just because of the barrier that the clot makes between the placental bed and villi but also because the release of prostaglandins causes a major degree of uterine spasm. This interferes with perfusion of the placenta, which remains attached. Blood tracking into the myometrium often goes as far as the peritoneum over the uterus, causing much pain and shock, with spasm of the uterine muscle. ### Emergency treatment of abruption Treat the shock
Update on selected inherited venous thrombotic disorders
Authors: Ryan S. Robetorye, George M. Rodgers
Journal: American Journal of Hematology (2001)

Abstract The inherited thrombophilias are a group of inherited conditions that predispose to thrombotic events. Most of the inherited thrombotic disorders are associated with venous thromboembolism rather than arterial thrombosis. Frequently, one or more predisposing genetic factors and/or environmental risk factor are identified in thrombosis patients. Significant advances in the identification of etiologies of inherited thrombosis have recently been reported. The most common inherited thrombotic disorders include activated protein C (APC) resistance (factor V Leiden), hyperhomocysteinemia, the prothrombin gene variant G20210A, elevated factor VIII levels, and deficiencies of thrombomodulin, protein C, protein S, and antithrombin. Less well characterized disorders include elevated factor IX, X, and XI levels. Recognition of these disorders now permits a laboratory diagnosis in approximately 70% of patients being evaluated for inherited thrombosis. This review focuses on the clinical and laboratory aspects of some of the most common inherited venous thrombotic disorders, including APC resistance, hyperhomocysteinemia, the prothrombin G20210A mutation, and elevated coagulation factor levels. Am. J. Hematol. 68:256–268, 2001. © 2001 Wiley‐Liss, Inc.
Spatiotemporal Trends and Age-Period-Cohort Modeling of the Incidence of Type 1 Diabetes Among Children Aged &amp;lt;15 Years in Norway 1973–1982 and 1989–2003
Authors: Geir Aamodt, Lars C. Stene, Pål R. Njølstad, Oddmund Søvik, Geir Joner
Journal: Diabetes Care (2007)

We have investigated age-period-cohort effects and spatial and temporal trends for the incidence of type 1 diabetes among 0- to 14-year-old children in Norway.We included children with the diagnosis of type 1 diabetes in Norway during 1973-1982 and 1989-2003. We studied age, calendar period, and birth cohort effects using Poisson regression, including Holford's method of parameterization, to model the dependencies between age, period, and cohort effects. To study spatiotemporal clustering of cases, we used spatial scan statistics.The overall incidence rate for the study population <15 years of age was 22.7 cases per 100,000 (95% CI 22.1-23.4), showing an average annual increase of 1.2% (95% CI 0.7-1.5%) during the study period. One specific area with 30% increased incidence rates was identified in the southern part of Norway during 1976-1980 (P = 0.001). Also, children born during 1964-1966 in a specific region in the southern part of Norway as well as children born during 1987-1989 in a region in northern Norway showed 2.0 and 2.6 times, respectively, higher incidence rates compared with the rest of the country (both P = 0.001).The incidence of type 1 diabetes among children increased during the study period. Birth cohort effects were identified using the spatiotemporal scan statistic but not using age, period, and birth cohort modeling. Such effects, within the relatively homogenous Norwegian population, suggest the influence of nongenetic etiological factors.
Cirrhosis Associated with the Australia Antigen in an Infant Who Acquired Hepatitis from Her Mother
Authors: R. Wright, J. R. Perkins, B. D. Bower, D. W. Jerrome
Journal: BMJ (1970)

A 19-week-old English girl developed acute viral hepatitis, which became chronic with persistent hepatosplenomegaly and abnormal liver function tests. Liver biopsy at 1 year showed an active cirrhosis with multinucleated giant cells. The Australia (Au) antigen was detected repeatedly in the infant's serum by immunodiffusion and by electron microscopy at the time of the acute attack and during the development of cirrhosis. She had apparently acquired the hepatitis from her mother, who had had jaundice at the end of pregnancy and for one month thereafter, and who was subsequently shown to be a carrier of Au antigen. Particles with surface projections resembling paramyxoviruses were observed in two of the later specimens of the infant's serum.
System of Ophthalmology, vol 6: Ocular Motility and Strabismus
Authors: Albert M. Potts
Journal: JAMA (1974)

With the appearance of this volume, the monumental<i>System of Ophthalmology</i>nears completion. Only one text volume has yet to appear. The present volume devoted to ocular motility and strabismus maintains the high quality of its predecessors. It is at once the most complete, the most current, and the most authoritative volume on the subject. It presents fairly in its 850 text pages the accumulated knowledge extracted by many generations of researchers and clinicians from stubborn and ungenerous Nature. It is my personal prejudice that the volume, along with the majority of today's practitioners, partakes too much of the "I'm alright, Jack" attitude. Our understanding of the normal physiology of binocularity, our understanding of how these mechanisms are disturbed in squint, and our accomplishments in the therapy of strabismus are less satisfactory than knowledge and therapeutic potential in any other subdivision of ophthalmology. The unjustified self-satisfaction results in too little
Effects of Cost Sharing on Seeking Care for Serious and Minor Symptoms
Authors: MARTIN F. SHAPIRO
Journal: Annals of Internal Medicine (1986)

To estimate the effect of cost sharing on seeking care for serious and minor symptoms, we analyzed data for 3539 persons aged 17 to 61 from the Rand Health Insurance Experiment. Participants were randomly assigned to a free-care group or to insurance plans requiring them to pay part of the costs (cost-sharing group). Annual surveys were administered to determine if participants had serious and minor symptoms during the preceding month and whether they saw a physician. Serious symptoms were judged by a panel of physicians to warrant care in most instances; minor symptoms were judged neither to be severe nor to warrant care in most instances. The cost-sharing group was nearly one third less likely than the free-care group to see a physician when they had minor symptoms (6.3% compared with 9.0%;p < 0.04). The free-care and cost-sharing groups did not differ significantly in seeking care for serious symptoms (22.3% compared with 17.9%;p = 0.095). However, for participants with low socioeconomic status who began the study in poor health, the prevalence of serious symptoms was higher in the cost-sharing than the free-care group (29.1% compared with 23.8%,p < 0.004).
Laminin molecular domains which alter metastasis in a murine model.
Authors: S H Barsky, C N Rao, J E Williams, L A Liotta
Journal: Journal of Clinical Investigation (1984)

Human and murine tumor cells contain cell surface receptors for the basement membrane glycoprotein laminin. Since a biologic role for the receptor had not previously been demonstrated, we explored the possibility that the laminin receptor may be involved in hematogenous metastases formation. Preincubation of metastatic murine melanoma cells with syngeneic whole laminin followed by tail vein injection increased tumor cell retention in the lung and strongly stimulated metastases formation. The domain of the laminin molecule responsible for stimulating metastases was identified. Laminin is a cross-shaped molecule with three short arms and one long arm. All arms have globular end regions. Purified protease-derived fragments of laminin were prepared which (a) lacked only the long arm of the molecule (alpha fragment) or, (b) lacked both the long arm and the globular end regions of the short arms (C1 fragment). Both types of fragments contained the laminin receptor binding region. The fragments had opposite effects on metastases. The alpha fragment stimulated metastases formation to the same extent as whole laminin. In contrast, the C1 fragment greatly reduced or abolished metastases formation in a dose-dependent manner. The C1 fragment also inhibited tumor cell attachment to whole amnion basement membrane in vitro. We conclude that intact globular end regions on the short arms (but not the long arm) of the cell surface receptor-bound laminin molecule are necessary for stimulating metastases by the intravenous route.