Graves Disease Induced by Radioactive Iodine
Authors: THOMAS W. H. KAY
Journal: Annals of Internal Medicine (1987)

Brief Reports1 December 1987Graves Disease Induced by Radioactive IodineTHOMAS W. H. KAY, M.B. B.S. B Med Sci., PAULA HEYMA, Ph.D., LEONARD C. HARRISON, M.D., F. I. R. MARTIN, M.D.THOMAS W. H. KAY, M.B. B.S. B Med Sci.Search for more papers by this author, PAULA HEYMA, Ph.D.Search for more papers by this author, LEONARD C. HARRISON, M.D.Search for more papers by this author, F. I. R. MARTIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-6-857 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExternal beam radiotherapy for nonthyroidal conditions has been followed by the development of Graves disease (1, 2) and thyroid eye disease is occasionally exacerbated after radioactive iodine (3). Both occurrences may be due to release of antigen from the damaged thyroid and consequent production of stimulating thyrotropin receptor antibodies (1). After131I treatment of thyrotoxicosis there is a dose-dependent increase in thyrotropin receptor antibodies also believed to be secondary to gland destruction (4). This finding is not generally clinically significant as the gland has been rendered unresponsive by radiation damage. In this patient, the indication for therapy was euthyroid multinodular...References1. WASNICHGRUMETPAYNEKRISS RFRJ. Graves' ophthalmopathy following external neck irradiation for nonthyroidal neoplastic disease. J Clin Endocrinol Metab. 1973;37:703-13. CrossrefMedlineGoogle Scholar2. MORTIMERHILLGALLIGANBRANSDENTYACKROESER RGJASH. Hypothyroidism and Graves' disease after mantle irradiation: a follow up study. Aust NZ J Med. 1986;16:347-51. CrossrefMedlineGoogle Scholar3. DONALDSONBAGSHAWKRISS SMJ. Supervoltage orbital radiotherapy for Graves' ophthalmopathy. J Clin Endocrinol Metab. 1973;37:276-85. CrossrefMedlineGoogle Scholar4. MCGREGORPETERSENCAPIFERRIEVEREDSMITHHALL AMRDBR. Effects of radioiodine on thyrotrophin binding inhibiting immunoglobulins in Graves' disease. Clin Endocrinol. 1979;11:437-44. CrossrefMedlineGoogle Scholar5. ROITTBROSTOFFMALE IJD. Immunology. Edinburgh: Churchill Livingstone; 1985:23.1-23.12. Google Scholar6. WEETMANMCGREGOR AA. Autoimmune thyroid disease: developments in our understanding. Endocr Rev. 1984;5:309-55. CrossrefMedlineGoogle Scholar7. DAHLBERGHOLMLUNDKARLSSONSAFWENBERG PGFJ. HLA-A, -B, -C and -DR antigens in patients with Graves' disease and their correlation with signs and clinical course. Acta Endocrinol (Copenh). 1981;97:42-7. CrossrefMedlineGoogle Scholar8. GUILLETLAIBRINER JMT. Immunological self, nonself discrimination. Science. 1987;235:865-70. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Royal Melbourne Hospital Parkville Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by131I-Induced Graves’ disease in patients treated for toxic multinodular goitre: systematic review and descriptive analysisRadioactive Iodine-Induced Graves' Disease in a Patient with Toxic AdenomaParadoxical exacerbation of preexisting Graves' disease induced by insufficient radioiodine treatment: a report of five patientsRelapses of hyperthyroidism in patients treated with radioiodine for nodular toxic goiter: Relation to thyroid autoimmunityAcute Psychotic State due to Hyperthyroidism Following Excision of a Mandible Bone Tumor: A Case ReportIatrogenic Thyrotoxicosis. Causal Circumstances, Pathophysiology and Principles of Treatment. Review of the LiteratureTransition of Nodular Toxic Goiter to Autoimmune Hyperthyroidism Triggered by 131I TherapyAppearance of anti TSH-receptor antibodies and clinical Graves’ disease after radioiodine therapy for hyperfunctioning thyroid adenomaAutoimmune Hyperthyroidism Occurring Late After Radioiodine Treatment for Volume Reduction of Large Multinodular Goiters*Has the Use of Antithyroid Drugs for Graves' Disease Become Obsolete?Invited reviewTreatment of Goiter for Cosmetic ReasonsGERALD BURKE, M.D. 1 December 1987Volume 107, Issue 6Page: 857-858KeywordsAntibodiesAntigensEndocrinologyEye diseasesThyroidThyroid-stimulating hormone Issue Published: 1 December 1987 PDF downloadLoading ...