Possible Interaction Between Amiodarone and Phenytoin
Authors: BRIAN McGOVERN
Journal: Annals of Internal Medicine (1984)

Brief Reports1 November 1984Possible Interaction Between Amiodarone and PhenytoinBRIAN McGOVERN, M. B., V.R. GEER, M.D., P.J. LaRAIA, M.D., HASAN GARAN, M.D., JEREMY N. RUSKIN, M.D.BRIAN McGOVERN, M. B.Search for more papers by this author, V.R. GEER, M.D.Search for more papers by this author, P.J. LaRAIA, M.D.Search for more papers by this author, HASAN GARAN, M.D.Search for more papers by this author, JEREMY N. RUSKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-5-650 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmiodarone, an investigational antiarrhythmic drug, has been reported to be effective in treating various cardiac tachyarrhythmias (1). Pharmacokinetic interactions with digoxin, warfarin, and class I antiarrhythmic drugs have been reported during treatment with amiodarone contrast barium enema, which showed a polypoid lesion at 15 cm; this patient refused biopsy or further diagnostic studies. The polyps seen during colonoscopy were small (< 5 mm) sessile polyps and had the gross appearance of hyperplastic polyps. Microscopic examination showed that two of the four polyps were adenomatous. Cancer of the colon in one patient was discovered on a routine sigmoidoscopy. Patient 2 had...References1. KLEINPARVEENGAVALERVANTHIEL IGJD. Colonic polyps in patients with acromegaly. Ann Intern Med. 1982;97:27-30. LinkGoogle Scholar2. MOONSIMPSONLIEVANS HMCH. Neoplasms in rats treated with pituitary growth hormone. Cancer Res. 1950;10:297-308. MedlineGoogle Scholar3. MUSTACCHISHIMKEN PM. Occurrence of cancer in acromegaly and in hypopituitarism. Cancer. 1957;10:100-4. CrossrefMedlineGoogle Scholar4. WRIGHTHILLLOWYFRASER ADCT. Mortality in acromegaly. Q J Med. 1970;39:1-16. MedlineGoogle Scholar5. SILVERBERGLUBERA EJ. A review of American Cancer Society estimates of cancer cases and deaths. CA. 1983;33:2-8. Google Scholar6. COPELANDMILLERJONES ELR. Prognostic factors in carcinoma of the colon and rectum. Am J Surg. 1968;116:875-81. CrossrefMedlineGoogle Scholar7. BOLANDKIM CY. Colonic polyps and the gastrointestinal polyposis syndromes. In: SLEISENGER MH, FORDTRAN JS, eds. Gastrointestinal Disease. 3rd ed. Philadelphia: WB Saunders; 1983:1197. Google Scholar8. LEAVITTKLEINKENDRICKSGAVALERVANTHIEL JIFJD. Skin tags: a cutaneous marker for colonic polyps. Ann Intern Med. 1983;98:928-30. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Spaulding Rehabilitation Hospital and Massachusetts General Hospital Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug Interactions in Neurocritical CarePhenytoinAmiodaronePhenytoinPharmacotherapy in the Neurosurgical Intensive Care UnitEffects of chronic treatment with amiodarone on hepatic demethylation and cytochrome P450ANTIDYSRHYTHMIC DRUGSAmiodaronePotentially Significant Drug Interactions of Class III Antiarrhythmic DrugsCARDIOVASCULAR DRUG-DRUG INTERACTIONSAnticonvulsant Combinations and InteractionsReplyPart IV: Class II, Class III, and Class IV Antiarrhythmic Drugs, Comparative Efficacy of Drugs, and Effect of Drugs on Mortality - A Review of Their Pharmaco kinetics, Efficacy, and Toxicity*Side effects from amiodaroneEffect of Phenytoin on the Clinical Pharmacokinetics of AmiodaroneSteady-state interaction between amiodarone and phenytoin in normal subjectsAntiarrhythmic MedicationsEffect of Amiodarone on the Disposition of Acetaminophen in the RatA general overview of amiodarone toxicity: Its prevention, detection, and managementThe efficacy of amiodarone in the treatment of ventricular tachycardia or ventricular fibrillationEffect of amiodarone on the disposition of procainamide in the ratAmiodarone in the Management of Cardiac Arrhythmias: Current ConceptsPart IV: Class II, Class III, and Class IV Antiarrhythmic Drugs, Comparative Efficacy of Drugs, and Effect of Drugs on Mortality ? A Review of Their Pharmaco kinetics, Efficacy, and ToxicityNeurological complications of cardiovascular therapyAmiodaroneThyroid dysfunction during chronic amiodarone therapyCardiac glycosides and drugs used in dysrhythmias 1 November 1984Volume 101, Issue 5Page: 650-651KeywordsBiopsyColonoscopyColorectal cancerDrug interactionsDrugsLesionsPharmacokineticsResearch fundingTachycardia Issue Published: 1 November 1984 PDF DownloadLoading ...