Over-the-Counter Chromium and Renal Failure
Authors: Walter G. Wasser
Journal: Annals of Internal Medicine (1997)

Letters15 October 1997Over-the-Counter Chromium and Renal FailureWalter G. Wasser, MD, Said A. Yusuf, MD, and Vivette D. D'Agati, MDWalter G. Wasser, MDNorth General Hospital New York, NY 10035Columbia University College of Physicians and Surgeons; New York, NY 10032Search for more papers by this author, Said A. Yusuf, MDNorth General Hospital New York, NY 10035Columbia University College of Physicians and Surgeons; New York, NY 10032Search for more papers by this author, and Vivette D. D'Agati, MDNorth General Hospital New York, NY 10035Columbia University College of Physicians and Surgeons; New York, NY 10032Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-8_Part_1-199710150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In our letter of January 1997, we reported the association of chromium picolinate ingestion with the development of renal failure. We carefully considered other possible causes. Our patient was receiving only three other medications at the time: terazosin and hydrochlorothiazide (since 1994) and verapamil (since 1995). Of these, only thiazides have been associated with the rare development of allergic interstitial nephritis. Many of these cases are poorly documented, and some were associated with underlying glomerular conditions that could have mediated tubulointerstitial damage [1]. Most of the patients presented with one or more signs of hypersensitivity (fever, rash, eosinophilia) ...References1. Lyons H, Pinn VW, Cortell S, Cohen JJ, Harrington JT. Allergic interstitial nephritis causing reversible kidney failure in four patients with idiopathic nephrotic syndrome. N Engl J Med. 1973; 288:124-8. Google Scholar2. Stearns DM, Belbruno JJ, Wetterhahn KW. A prediction of chromium (III) accumulation in humans from chromium dietary supplements. FASEB J. 1995; 9:1650-7. Google Scholar3. Jenrette KW. Chromate metabolism in liver microsomes. Biol Trace Elem Res. 1979; 1:55-62. Google Scholar4. Mather AK, Chandra SV, Tandon SK. Comparative toxicity of trivalent and hexavalent chromium to rabbits. II. Morphological changes in some organs. Toxicology. 1977; 8:53-61. Google Scholar Author, Article, and Disclosure InformationAuthors: Walter G. Wasser, MD; Said A. Yusuf, MD; Vivette D. D'Agati, MDAffiliations: North General Hospital New York, NY 10035Columbia University College of Physicians and Surgeons; New York, NY 10032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byToxicology of Chromium(III)Scientific Opinion on the safety of chromium picolinate as a source of chromium added for nutritional purposes to foodstuff for particular nutritional uses and to foods intended for the general populationChromium picolinate, zinc picolinate and zinc picolinate dihydrate added for nutritional purposes in food supplementsStudy of Oxidative Damage in Growing–Finishing Pigs with Continuous Excess Dietary Chromium Picolinate IntakeAcute Tubular Necrosis Associated with Chromium Picolinate–Containing Dietary SupplementThe nutritional supplement chromium picolinate generates oxidative DNA damage and peroxidized lipids in vivoThe bioinorganic chemistry of chromium(III)Chromium update: examining recent literature 1997-1998Chromium Picolinate Toxicity 15 October 1997Volume 127, Issue 8_Part_1Page: 656 ePublished: 15 August 2000 Issue Published: 15 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...