Parathyroid Hormone Radioimmunoassay
Authors: JOEL F. HABENER
Journal: Annals of Internal Medicine (1979)

Editorials1 November 1979Parathyroid Hormone RadioimmunoassayJOEL F. HABENER, M.D., GINO V. SEGRE, M.D.JOEL F. HABENER, M.D.Search for more papers by this author, GINO V. SEGRE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-782 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe study by Raisz and colleagues reported in this issue (1), although based on a small number of samples, illustrates both the assets and limitations of commercially available radioimmunoassays for immunoreactive parathyroid hormone (iPTH). When the same samples from 15 patients with surgically proven hyperparathyroidism were analyzed, good agreement was found among three of the four participating laboratories. A positive correlation between serum calcium and iPTH was seen in two of the four laboratories and is reported to be present in a third when more samples are analyzed (2). The values obtained for plasma iPTH in 14 hypercalcemic patients with...References1. RAISZYAJNIKBOCKMANBOWER LCRB. Comparison of commercially available parathyroid hormone immunoassays in the differential diagnosis of hypercalcemia due to primary hyperparathyroidism or malignancy. Ann Intern Med. 1979;91:739-40. LinkGoogle Scholar2. ARNAUDTSAOLITTLEDIKE CHT. Radioimmunoassay of human parathyroid hormone in serum. J Clin Invest. 1971;50:21-34. CrossrefMedlineGoogle Scholar3. BERSONYALOW SR. Immunochemical heterogeneity of parathyroid hormone in plasma. J Clin Endocrinol Metab. 1968;28:1037-47. CrossrefMedlineGoogle Scholar4. ARNAUDTSAOOLDHAM CHS. Native human parathyroid hormone: an immunochemical investigation. Proc Natl Acad Sci USA. 1970;67:415-22. CrossrefMedlineGoogle Scholar5. CANTERBURYREISS JE. 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Vol. 2 New York: Academic Press; 1978. Google Scholar25. BOONSTRAJACKSON CC. Serum calcium survey for hyperparathyroidism: results in 50, 000 clinic patients. Am J Clin Pathol. 1971;55:523-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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