Immunogenetic Markers in Autoimmune Disease
Authors: JANARDAN P. PANDEY
Journal: Annals of Internal Medicine (1984)

Editorials1 December 1984Immunogenetic Markers in Autoimmune DiseaseJANARDAN P. PANDEY, PH.D., H. HUGH FUDENBERG, M.D.JANARDAN P. PANDEY, PH.D.Search for more papers by this author, H. HUGH FUDENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-6-868 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past few years several studies have examined the role of two highly polymorphic immunogenetic systems, HLA (human leukocyte antigen) on chromosome 6 and Gm (genetic markers of IgG) on chromosome 14, in the pathogenesis of various autoimmune diseases. These studies fall in two categories: population studies and family studies. The former provide information on the "association" of the putative disease susceptibility locus (or loci) and the marker locus, whereas the latter furnish knowledge about the "linkage" relationship between the loci involved.These two terms, association and linkage, are often confused. An association is shown in population studies when...References1. SVEJGAARD A, PLATZ P, and RYDER L. HLA and disease 1982—a survey. Immunol Rev. 1983;70:193-218. CrossrefMedlineGoogle Scholar2. NAKAO Y, MATSUMOTO H, and MIYAZAKI T. IgG heavy chain allotypes (Gm) in autoimmune disease. Clin Exp Immunol. 1980;42:20-6. MedlineGoogle Scholar3. WHITTINGHAM S, MATHEWS J, SCHANFIELD M, TAIT B, and MACKAY I. Interaction of HLA and Gm in autoimmune chronic active hepatitis. Clin Exp Immunol. 1981;43:80-6. MedlineGoogle Scholar4. WHITTINGHAM S, MATHEWS J, SCHANFIELD M, TAIT B, and MACKAY I. HLA and Gm genes in systemic lupus erythematosus. Tissue Antigens. 1983;21:50-7. CrossrefMedlineGoogle Scholar5. UNO H, SASAZUKI T, TAMAI H, and MATSUMOTO H. TWO major genes, linked to HLA and Gm, control susceptibility to Graves' disease. Nature. 1981;292:768-70. CrossrefMedlineGoogle Scholar6. REVEILLE J, WILSON R, PROVOST T, BIAS W, and ARNETT F. Primary Sjögren's syndrome and other autoimmune diseases in families: prevalence and immunogenetic studies in six kindreds. Ann Intern Med. 1984;101;748-56. LinkGoogle Scholar7. ALPER C, AWDEH Z, RAUM D, and YUNIS E. Extended major histocompatibility complex haplotypes in man: role of alleles analogous to murine t mutants. Clin Immunol Immunopathol. 1982;24:276-85. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JANARDAN P. PANDEY, PH.D.; H. HUGH FUDENBERG, M.D.Affiliations: Medical University of South Carolina Charleston, South Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClass II HLA Antigens in Autoimmune and Immune-Mediated DiseasesLaboratory Investigation of Autoimmune Endocrine Diseases 1 December 1984Volume 101, Issue 6Page: 868-869KeywordsAutoimmune diseasesChromosomal diseasesFallsGenetic diseasesHuman leukocyte antigenPathogenesisResearch grants ePublished: 1 December 2008 Issue Published: 1 December 1984 PDF downloadLoading ...