tbuckley/cabot-search huggingface dataset:
Multivariate analysis of cancer mortalities for selected sites in 24 countries.
Authors: H Yanai, Y Inaba, H Takagi, S Yamamoto
Journal: Environmental Health Perspectives (1979)

In order to analyze the pattern in the geographical distribution of cancer death in 24 countries of the world, correlation coefficients were calculated between pairs of mortality rates of different cancer sites, using the data for 13 sites in males and 14 sites in females over 18 years from 1950 to 1967. Then factor analysis by means of varimax method was performed on 13 x 13 correlation matrix for males, 14 x 14 correlation matrix for females and 27 x 27 correlation matrix for males and females combined. As a result of factor analysis, three factors are extracted, which are commonly recognized in both males and females. The first factor has high positive factor loadings on pancreas, prostate (for males), skin, and intestine cancers, and negative loadings on stomach and liver cancers. The second factor has high positive factor loading on rectum, intestine, and lung cancers, and the third factor on larynx, oral, and esophagus cancers. Factor analysis based on 27 x 27 correlation matrix revealed that the third factor of both sexes are heterogeneous with regards to the distributions of the factor score. In order that we may find some clues to develop an etiological hypothesis for each site of cancer, we obtained the correlation coefficient between the scores of the extracted factors and the variables on food and environmental agent, and performed stepwise regression methods as well. One of the most striking results we obtained was that excessive drinking of alcohol and the lack of appropriate intake of fruit are suspected as etiological promoters in the pathogenesis of oral, esophagus, and larynx cancers in males.
Avoidance of high concentration oxygen in chronic obstructive pulmonary disease
Authors: B. R. O'Driscoll, R. Beasley
Journal: BMJ (2010)

Routine use may also be harmful in several other medical emergencies

Oxygen was used to treat several diseases as early as the 1790s, and the belief that “purified air” was better than ordinary air persisted among doctors and the general public for the next two centuries.1 In the early 1960s, Moran Campbell recognised the danger of hypercapnic respiratory failure (carbon dioxide retention) caused by high concentrations of oxygen in the treatment of acute exacerbations of chronic obstructive pulmonary disease.2 Subsequent research has consistently reported adverse outcomes after the use of uncontrolled oxygen treatment in this condition.3 4 Evidence on the benefits and harms of the use of oxygen in acute exacerbations of chronic obstructive pulmonary disease has led all specialties in the United Kingdom to recommend controlled oxygen treatment with a target saturation range (usually 88-92%) in this condition.5 However, this recommendation was limited by the lack of level 1 evidence, because no randomised controlled trials were available.6

The linked cluster randomised trial by Austin and colleagues (doi:10.1136/bmj.c5462) finally fills this …
Consciousness, accessibility, and the mesh between psychology and neuroscience
Authors: Ned Block
Journal: Behavioral and Brain Sciences (2007)

How can we disentangle the neural basis of phenomenal consciousness from the neural machinery of the cognitive access that underlies reports of phenomenal consciousness? We see the problem in stark form if we ask how we can tell whether representations inside a Fodorian module are phenomenally conscious. The methodology would seem straightforward: Find the neural natural kinds that are the basis of phenomenal consciousness in clear cases--when subjects are completely confident and we have no reason to doubt their authority--and look to see whether those neural natural kinds exist within Fodorian modules. But a puzzle arises: Do we include the machinery underlying reportability within the neural natural kinds of the clear cases? If the answer is "Yes," then there can be no phenomenally conscious representations in Fodorian modules. But how can we know if the answer is "Yes"? The suggested methodology requires an answer to the question it was supposed to answer! This target article argues for an abstract solution to the problem and exhibits a source of empirical data that is relevant, data that show that in a certain sense phenomenal consciousness overflows cognitive accessibility. I argue that we can find a neural realizer of this overflow if we assume that the neural basis of phenomenal consciousness does not include the neural basis of cognitive accessibility and that this assumption is justified (other things being equal) by the explanations it allows.
Aspiration of Intrathoracic Abscess
Authors: Guy S. Reeder
Journal: JAMA (1978)

Three cases illustrate that acute respiratory failure may be precipitated by spontaneous drainage of lung abscess or pleural empyema intrabronchially with diffuse aspiration of the contents bilaterally. This condition is especially hazardous if the cavity is large and the patient is debilitated or obtunded. The acute onset may mimic aspiration of gastric contents. Immediate studies of tracheal aspirate and roentgenograms of the chest should define the aspiration of intrathoracic abscess contents as the cause of acute respiratory failure.
Essential Thrombocythaemia and Peripheral Gangrene
Authors: F. E. Preston, I. G. Emmanuel, D. A. Winfield, R. G. Malia
Journal: BMJ (1974)

Six patients are described in whom gangrene of one or more toes occurred as the presenting feature of essential thrombocythaemia. Spontaneous platelet aggregation was observed in platelet-rich plasma from four patients and platelet aggregation after the addition of adenosine diphosphate and collagen was highly abnormal in samples from all six. All of the patients described dramatic relief of pain within six hours of ingestion of aspirin and this coincided with disappearance of the spontaneous platelet aggregation and collagen-induced platelet aggregation. Treatment with phosphorus-32 corrected the platelet count and there were no further recurrences of peripheral vascular disease. Platelet function tests performed at the time all gave normal results. It is concluded that essential thrombocythaemia is an important and treatable cause of peripheral vascular disease.
Simulation model for planning renal services in a district health authority.
Authors: P. G. Bolger, R. Davies
Journal: BMJ (1992)

To investigate the use of a computer simulation model in planning and budgeting for renal replacement services.Regional renal unit.The simulation provided projections that accurately reflected the actual numbers of people maintained on different forms of renal replacement therapy in previous years. Projections up to the end of the century showed that with no change in the demand for the service the total number of people on the renal replacement programme would increase by 40%. Increasing the uptake of new patients from 40 per million to 55 per million would mean an increase of 66% in patient numbers over the same period. Similarly, at present day prices the cost of providing the service would rise by 31% with no change in demand and by twice this with the greater uptake of new patients. Increasing the number of transplant operations was shown to offer little prospect of a reduction in these costs.The simulation program could be used by individual renal units to evaluate different treatment policies and to budget for resource use. Even at current demand levels resource requirements for renal replacement therapy will continue to grow until after the end of the century.
Serum markers of angiogenesis and myocardial ultrasonic tissue characterization in patients with dilated cardiomyopathy
Authors: Tomoaki Ohtsuka, Katsuji Inoue, Yuji Hara, Norikatsu Morioka, Kiyotaka Ohshima, Jun Suzuki, Akiyoshi Ogimoto, Yuji Shigematsu, Jitsuo Higaki
Journal: European Journal of Heart Failure (2005)
Quantitative measurement of left ventricular volumes in man from radiopaque epicardial markers.
Authors: D L Vine, H T Dodge, M Frimer, D K Stewart, J Caldwell
Journal: Circulation (1976)

The distances between three or four radiopaque markers located on the left ventricular epicardial surface at the apex and in the region of the minor axes in 22 subjects showed close correlations with left ventricular chamber radii, length, volume and wall thickness determined from biplane angiograms over the range of stroke volume. The markers were previously placed during heart surgery. Regression equations relating the distances between epicardial markers and chamber volumes were used to predict volumes for other beats. There was close agreement of end-diastolic, end-systolic, and stroke volumes as determined by the angiographic and epicardial marker methods for premature atrial contraction beats and post premature contraction beats, and in studies performed during rest and exercise. Time-volume curves determined by the epicardial marker and angiographic methods were similar. It is concluded that epicardial marker measurements can be used to quantitate beat-to-beat left ventricular chamber volume and dimension changes.
THE ASSOCIATION BETWEEN DUAL ANTIPLATELET THERAPY AND IN–STENT THROMBUS FORMATION IN IN–STENT RESTENOSIS LESIONS AFTER SIROLIMUS–ELUTING STENT IMPLANTATION ASSESSED WITH OPTICAL COHERENCE TOMOGRAPHY
Authors: Takeshi Tada, Kazushige Kadota, Yu Izawa, Hidewo Amano, Michitaka Nakamura, Tahei Ichinohe, Shunsuke Kubo, Masatomo Ozaki, Yusuke Hyodo, Koshi Miyake, Yuki Hayakawa, Naoki Saito, Hideaki Otsuji, Suguru Otsuru, Daiji Hasegawa, Yoshikazu Shigemoto, Seiji Habara, Hiroyuki Tanaka, Yasushi Fuku, Harumi Katoh, Hiroyuki Yamamoto, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2013)
Effects of Red Wine and Vodka on Collateral-Dependent Perfusion and Cardiovascular Function in Hypercholesterolemic Swine
Authors: Louis M. Chu, Antonio D. Lassaletta, Michael P. Robich, Yuhong Liu, Thomas Burgess, Roger J. Laham, Joseph D. Sweeney, Tun-Li Shen, Frank W. Sellke
Journal: Circulation (2012)

Moderate consumption of alcohol, particularly red wine, has been shown to decrease cardiac risk. We used a hypercholesterolemic swine model of chronic ischemia to examine the effects of 2 alcoholic beverages on the heart. Yorkshire swine fed a high-cholesterol diet underwent left circumflex ameroid constrictor placement to induce chronic ischemia at 8 weeks of age. One group (HCC, n=9) continued on the diet alone, the second (HCW, n=8) was supplemented with red wine (pinot noir, 12.5% alcohol, 375 mL daily), and the third (HCV, n=9) was supplemented with vodka (40% alcohol, 112 mL daily). After 7 weeks, cardiac function was measured, and ischemic myocardium was harvested for analysis of perfusion, myocardial fibrosis, vessel function, protein expression, oxidative stress, and capillary density. Platelet function was measured by aggregometry. Perfusion to the ischemic territory as measured by microsphere injection was significantly increased in both HCW and HCV compared with HCC at rest, but in only the HCW group under ventricular pacing. Microvessel relaxation response to adenosine 5'-diphosphate was improved in the HCW group alone as was regional contractility in the ischemic territory, although myocardial fibrosis was decreased in both HCW and HCV. Expression of proangiogenic proteins phospho-endothelial nitric oxide synthase and vascular endothelial growth factor was increased in both HCW and HCV, whereas phospho-mammalian target of rapamycin was increased only in the HCV group. Expression of Sirt-1 and downstream antioxidant phospho-FoxO1 was increased only in the HCW group. Protein oxidative stress was decreased in the HCW group alone, whereas capillary density was increased only in the HCV group. There was no significant difference in platelet function between groups. Moderate consumption of red wine and vodka may reduce cardiovascular risk by improving collateral-dependent perfusion through different mechanisms. Red wine may offer increased cardioprotection related to its antioxidant properties.
Abstract 4888: Parallel Improvement In Central And Peripheral Pulse Pressure And Plasma Natriuretic Peptide In Hypertension With Diastolic Dysfunction: Exceed Trial Investigators
Authors: Anil Verma, Akshay Desai, Amira H Hassanein, Chung-Lieh Hung, Katarzyna Juszczynska, Ricardo Rocha, Robert Hilkert, Joseph Izzo, Suzanne Oparil, Scott D Solomon
Journal: Circulation (2008)
Harvey Cushing: Book Collector
Authors: Madeline E. Stanton
Journal: JAMA (1965)

Following a visit to the Osler Library at McGill University in 1935, Harvey Cushing decided to leave his books to Yale University and to interest as many as possible of his book-collecting friends to do the same. He first approached his longtime friend and adviser, Arnold C. Klebs of Nyon, Switzerland, whom he asked to join in this venture of creating a center for the study of medical history. Klebs (the son of Edwin Klebs of Klebs-Loeffler bacillus fame and a great bibliophile) had no reason to make Yale such an outstanding donation, other than his friendship for Dr. Cushing, but after the initial surprise he became rather intrigued with the suggestion. John F. Fulton, who had come to Yale in 1930 as professor of physiology —and with an outstanding library he had collected in less than a decade—was the second desired recruit. He proved a sympathetic protagonist and in
Intraoperative diagnosis of nonpigmented nail tumours with<i>ex vivo</i>fluorescence confocal microscopy: 10 cases
Authors: S. Debarbieux, R. Gaspar, L. Depaepe, S. Dalle, B. Balme, L. Thomas
Journal: British Journal of Dermatology (2014)

Ex vivo fluorescence confocal microscopy (FCM) permits real-time imaging of freshly excised skin tissues. Its usefulness as a time-sparing alternative to frozen sections in Mohs surgery of basal cell carcinoma is well documented.The purpose of this study was to describe the ex vivo FCM features of a series of benign and malignant nonpigmented tumours of the nail unit, and to correlate them with conventional histopathology.Nail apparatus tumours from 10 patients were imaged during surgical exploration using ex vivo FCM after immersion in acridine orange. Confocal mosaics of the freshly performed biopsies were evaluated in real time and retrospectively compared with haematoxylin and eosin sections.Our series included two invasive epithelial tumours (Group 1), four in situ or minimally invasive squamous cell carcinomas (SCC) (Group 2), three benign epithelial tumours (Group 3) and one nodular melanoma (Group 4). The correlation was excellent for malignant epithelial tumours exhibiting marked cytological and architectural atypias (Bowen disease, invasive SCC and onycholemmal carcinoma). Onychomatricomas exhibited a very peculiar aspect with densely cellular papillae. The correlation was less favourable for minimally invasive well-differentiated SCCs with slight cytological atypias. The correlation was poor for our case of amelanotic invasive subungual melanoma.Ex vivo FCM could be a useful tool to shorten management of nonpigmented nail tumours: in the case of a malignant tumour, it could indeed lead to performing wide excision during the same surgical procedure and possibly assessing the surgical margins.
Good Health at Low Cost 25 years on: lessons for the future of health systems strengthening
Authors: Dina Balabanova, Anne Mills, Lesong Conteh, Baktygul Akkazieva, Hailom Banteyerga, Umakant Dash, Lucy Gilson, Andrew Harmer, Ainura Ibraimova, Ziaul Islam, Aklilu Kidanu, Tracey P Koehlmoos, Supon Limwattananon, VR Muraleedharan, Gulgun Murzalieva, Benjamin Palafox, Warisa Panichkriangkrai, Walaiporn Patcharanarumol, Loveday Penn-Kekana, Timothy Powell-Jackson, Viroj Tangcharoensathien, Martin McKee
Journal: The Lancet (2013)
Progress on Posttraumatic Stress Disorder
Authors: Kenneth W. Kizer
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23
Authors: H-S Shiah, Y-Y Kuo, J-L Tang, S-Y Huang, M Yao, W Tsay, Y-C Chen, C-H Wang, M-C Shen, D-T Lin, K-H Lin, H-F Tien
Journal: Leukemia (2002)
Systemic AA amyloidosis induced by liver cell adenoma.
Authors: P Fievet, H Sevestre, M Boudjelal, L H Noel, F Kemeny, D Franco, J Delamarre, J P Capron
Journal: Gut (1990)

Systemic AA amyloidosis is a rare complication of benign tumours. This report describes a patient with hepatocellular adenoma associated with reactive AA amyloidosis. He had a nephrotic syndrome with deteriorating renal function and an increase of serum concentrations of acute phase proteins, mainly C-reactive protein. Resection of the tumour was followed by improvement in renal function and a marked decrease of the serum concentrations of acute phase proteins.
THE "PUSTULAR BACTERID" TYPE OF REACTION IN EPIDER-MOPHYTON INFECTION AND IN A CASE OF CHRONIC ECZEMA
Authors: G. B. DOWLING
Journal: British Journal of Dermatology (1938)

Journal Article THE "PUSTULAR BACTERID" TYPE OF REACTION IN EPIDER‐MOPHYTON INFECTION AND IN A CASE OF CHRONIC ECZEMA Get access G. B. DOWLING, M.D., F.R.C.P. G. B. DOWLING, M.D., F.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 50, Issue 3, 1 March 1938, Pages 139–140, https://doi.org/10.1111/j.1365-2133.1938.tb10513.x Published: 01 March 1938
Stammering and the Allergic Diathesis
Authors: A. M. Kennedy, D. A. Williams
Journal: BMJ (1938)

the average age of the patients iL. the various groups is, somewhat to our surprise, almost identical: conserva- tive mastoids, 23 years old; modified radicals, 251 years; radicals, 24 years.Summary A survey is given of cases operated on for chronic otorrhoea during the past year.The results of the various operations are examined.Indications for the choice of each method are discussed.
Prognostic signs in chronic myelocytic leukemia
Authors: Robert F. Schilling, John J. Crowley
Journal: American Journal of Hematology (1979)

Abstract In a retrospective search for prognostic factors in 127 patients with chronic myelocytic leukemia we found that thrombocytopenic patients had a significantly shortened life‐span. Patients with the Philadelphia chromosome lived longer and were significantly younger than those lacking it. Females lived longer than males. Numerous other single features failed to correlate significantly with survival, but several combinations of two did. Patients having a low hematocrit with a low white blood count had an impressively short life‐span compared to all others. Those having a high cholesterol and a low uric acid survived significantly longer than all others.
ACE Gene Polymorphism as a Risk Factor for Ischemic Cerebrovascular Disease
Authors: B Agerholm-Larsen, A Tybjaerg-Hansen, R Frikke-Schmidt, M L Grønholdt, G Jensen, B G Nordestgaard
Journal: Annals of Internal Medicine (1997)

Background: Researchers have suggested that the deletional allele of the ACE (angiotensin-converting enzyme) gene insertion-deletion polymorphism is a potent risk factor for myocardial infarction. This association could not be confirmed in the Copenhagen City Heart Study, in which 10 150 persons were studied. The ACE gene polymorphism has also recently been suggested as a potent risk factor for ischemic cerebrovascular disease. Objective: To investigate the association between ACE gene polymorphism and ischemic cerebrovascular disease. Design: Two case-referent studies and a cross-sectional study. Setting: University hospital in Copenhagen, Denmark. Participants: Case-referent study 1: 35 women and 38 men who developed ischemic cerebrovascular disease before 50 years of age compared with 1454 women and 1737 men from a general population sample. Case-referent study 2: 82 women and 137 men with ischemic cerebrovascular disease and carotid stenosis greater than 40% compared with 4273 women and 3091 men from the general population sample. Cross-sectional study of the general population sample: 67 women and 93 men with ischemic cerebrovascular disease compared with 4077 women and 3156 men without such disease. Measurements: Genotype; age; body mass index; smoking habits; levels of lipids, lipoproteins, apolipoproteins, and fibrinogen; and diagnosis of hypertension, diabetes mellitus, and ischemic cerebrovascular disease. Results: Odds ratios for ischemic cerebrovascular disease by ACE genotype classes were not significantly different from 1.0 in women or men in any of the three studies, separately or combined. In a logistic regression analysis that controlled for age and conventional cardiovascular risk factors, odds ratios in either sex still did not significantly differ from 1.0 in any study, separately or combined. Conclusion: In two case-referent studies, a cross-sectional study, and the three studies combined, no statistically significant difference was found in the development of ischemic cerebrovascular disease between genotype classes of the ACE gene polymorphism in women or men.
Double blind, placebo-controlled study of long-term intermittent dobutamine infusion with concomitant oral amiodarone for end stage heart failure
Authors: Eleftheria Tsagalou, Maria Anastasiou-Nana, George Alexopoulos, John Terrovitis, Konstantinos Chalkias, Christos Gialamas, Konstantinos Christodoulou, John Kanakakis, John N. Nanas
Journal: Journal of the American College of Cardiology (2003)
Agency is under fire for refusing to supply details of sudden deaths after first dose of multiple sclerosis drug
Authors: J. Wise
Journal: BMJ (2012)

The European Medicines Agency has been criticised for refusing to supply the French independent drug bulletin, Prescrire , with data on cases of sudden death after the first dose of the multiple sclerosis drug fingolimod.

Fingolimod was authorised by the European Medicines Agency in March 2011 for the treatment of relapsing remitting multiple sclerosis in patients whose disease has failed to respond to a β interferon or is severe and getting worse rapidly.

On 20 December 2011 the US Food and Drug Administration reported that a patient with multiple sclerosis had died within 24 hours of taking the first dose of fingolimod, marketed by Novartis. The patient was also taking a β blocker and a calcium channel blocker.

On 22 December Prescrire contacted the European Medicines Agency to ask for a review of the serious adverse effects of fingolimod and for the initial European Periodic Safety Update Report, which must be filed with the agency within six months …