Shock, Seizures, and Coma with Alkalosis During Mechanical Ventilation
Authors: KAYE H. KILBURN
Journal: Annals of Internal Medicine (1966)

Article1 November 1966Shock, Seizures, and Coma with Alkalosis During Mechanical VentilationKAYE H. KILBURN, M.D.KAYE H. KILBURN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-977 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEffective therapy for patients with severe repiratory failure has produced new hazards which include increased acidosis during oxygen administration (1), pneumonia from breathing aerosols from contaminated nebulizers (2), cardiac arrhythmias associated with rapid reduction of carbon dioxide tension (3, 4), and hypochloremic alkalosis from rapid removal of carbon dioxide in chloride-depleted patients (5-7). Deterioration of mental and neurologic function has been associated frequently with increased acidosis due to reduction of alveolar ventilation (8-10). Recently confusion, seizures, and shock have been described in patients with severe alkalosis due to mechanical hyperventilation (6, 11, 12).That severe alkalosis as well as severe...References1. COMROEBAHNSONCOATES JHEREO: Mental changes occurring in chronically anoxemic patients during oxygen therapy. JAMA 143: 1044, 1950. CrossrefMedlineGoogle Scholar2. REINARZPIERCEMAYSSANFORD JAAKBBJP: The potential role of inhalation therapy equipment in nosocomial pulmonary infection. J. Clin. Invest. 44: 831, 1965. CrossrefMedlineGoogle Scholar3. FLEMMAYOUNG RJWG: The metabolic effects of mechanical ventilation and respiratory alkalosis in postoperative patients. Surgery 56: 36, 1964. MedlineGoogle Scholar4. LURIEJONESLINDEPRICEDRIPPSPRICE AAREHWMLRDHL: Cyclopropane anesthesia. I. Cardiac rate and rhythm during steady states of cyclopropane anesthesia at normal and elevated end-expiratory carbon dioxide tensions. Anesthesiology 19: 457, 1958. CrossrefMedlineGoogle Scholar5. 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HOWARDLEATHARTDORNHORSTSHARPEY-SCHAFER PGLACEP: "Mess trick" and the "fainting lark." Brit. Med. J. 2: 382, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KAYE H. KILBURN, M.D.Affiliations: Durham, North CarolinaFrom the Department of Medicine, Duke University Medical Center, and the Medical Service, Veterans Administration Hospital, Durham, N. C.Portions of this study were presented before the Southern Sectional Meeting of the American Federation for Clinical Research, January 27, 1966, New Orleans, La.Requests for reprints should be addressed to Kaye H. Kilburn, M.D., Associate Professor of Medicine, Duke University Medical Center, Durham, N. C. 27706. 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(LOND.), FREDERIC ELDRIDGE, M.D., F.A.C.P.Complications of Acute Respiratory FailureTRYGGVI ASMUNDSSON, M.D., KAYE H. KILBURN, M.D.Metabolic alkalosis following heart surgeryPrevention of metabolic alkalosis following heart surgeryOXYGENATION, INTUBATION AND VENTILATION IN ACUTE RESPIRATORY FAILURE6. Respiratorische Entgleisungen mit Bewußtseinsstörungen in der ChirurigeEpilepsy 1 November 1966Volume 65, Issue 5Page: 977-984KeywordsArrhythmiaCarbon dioxideComaEpileptic seizuresHospital medicineMedical servicesOxygenPneumoniaShockVentilators ePublished: 1 December 2008 Issue Published: 1 November 1966 PDF downloadLoading ...