tbuckley/cabot-search huggingface dataset:
SOMA--Society of Medical Authors. Summing-up.
Authors: I J Davies
Journal: BMJ (1979)

The idea of forming a society to represent the interests of authors of medical books has developed over the last few years and started as a result of the accidental meeting of a number of authors of moderately successful medical books.First com- parisons suggested that there was such disparity between some publishers' terms that it was obvious that some authors were at a disadvantage; for example, royalty rates paid by publishers generally seemed to vary between 7-5 and 150o of the UK retail price of the book.It was also evident that the taxation of royalties and the expenses allowed against royalties before tax was so variable as to suggest almost arbitrary application of the presumed rules.Individual authors' influence over publishers in respect of the format and production of their books varied from complete participation by the author in discussions about production to a complete inability to influence even major decisions such as production of paperback or hardback versions.Authors themselves spanned a whole range-from those who saw little or no fault with their publishers to those who asserted that they would prefer to hide their light rather than return to their previous publisher.We therefore circulated 3000 medical authors culled from the Medical Directory, and devised a suitable title for our prospec- tive society-hitting on the Society of Medical Authors, which conveniently becomes the acronym SOMA.We had replies from over 1000; the eminence and prestige of some of those who replied were surprising.The literary output of those interested ranged from standard medical texts to obscure poetry, musical scores, and political pamphlets.About 850 of those who replied said that they would be interested in a society for medical authors and felt that there was a need for such a society.'Drive, 1978, p 40.
CEREBROSPINAL FLUID SUGAR IN UNCOMPLICATED AND UNTREATED NEUROSYPHILIS
Authors: Purcell G. Schube, Robert C. Lewis
Journal: American Journal of Psychiatry (1933)

A study of the cerebrospinal fluid sugar as measured in mg. per 100 cc. of cerebrospinal fluid in uncomplicated and untreated neurosyphilis is presented. The values obtained range between 40 and 112 mg. with a mean value for all cases of 62.75 mg. No true difference could be demonstrated between the mean values of the different types of neurosyphilis studied.
Histological findings in chronic hepatitis C with autoimmune features
Authors: A J Czaja, H A Carpenter
Journal: Hepatology (1997)

To evaluate the histological findings in patients with chronic hepatitis C and autoimmune features, liver tissue specimens from 60 patients were graded under code for individual features and composite patterns that denoted autoimmune, viral, combined autoimmune and viral, and nondiscriminative changes. Portal, interface, and acinar hepatitis in any combination with plasma cell infiltration connoted an autoimmune pattern that was associated with higher serum levels of gamma-globulin (2.4 +/- 0.2 g/dL vs. 1.7 +/- 0.1 g/dL; P = .0003) and immunoglobulin G (2,211 +/- 227 mg/dL vs. 1,508 +/- 83 mg/dL; P = .001) than patients with other patterns. Patients with the autoimmune pattern also had a greater frequency of cirrhosis (43% vs. 8%; P = .003), higher mean Knodell score (13.2 +/- 0.9 vs. 6.8 +/- 0.9; P < .0001), and a greater occurrence of high-titer smooth muscle antibodies (SMA) (13% vs. 0%; P = .05) than patients with other histological findings. HLA DR3 also occurred more frequently in these individuals than in other patients (48% vs. 15%; P = .01) and normal subjects (43% vs. 16%; P = .01). Patients with nondiscriminative patterns and interface hepatitis had clinical findings similar to those with autoimmune patterns, except for a lower mean serum level of gamma-globulin. We conclude that the composite histological pattern that resembles autoimmune hepatitis is associated with greater immunoreactivity, inflammatory activity, and disease severity than other patterns. Interface hepatitis may be the most important histological finding associated with these clinical manifestations.
Haemolytic uraemic syndrome: therapeutic effect of plasma infusion.
Authors: R Misiani, A C Appiani, A Edefonti, E Gotti, A Bettinelli, M Giani, E Rossi, G Remuzzi, G Mecca
Journal: BMJ (1982)

The therapeutic effect of plasma infusion was evaluated in 10 children and seven adults with haemolytic uraemic syndrome. All but one patient responded to this treatment with rapid disappearance of haematological abnormalities. The patient who apparently failed to respond to plasma infusion obtained complete remission of the disease after plasmapheresis. Although 15 of the 17 patients were anuric or oliguric on admission, renal function recovered completely in eight children and two adults. Seven patients showed residual chronic renal failure and two required long-term maintenance haemodialysis. Treatment with plasma was also successful in patients with relapses or recurrent episodes. Plasma infusion is a promising therapeutic approach for the haemolytic uraemic syndrome and deserves further study in clinical trials.
Letter: Abortion and promiscuity.
Authors: R G Wilkins
Journal: BMJ (1975)

the natural increase in milk concentration throughout the feed,56 a mid-feed milk fat concentration of less than 20% is suggestive of undernutrition in a mother who is ex- periencing difficulty in lactating or whose baby's weight gain is failing.Fhe successful establishment of lactation could be dependent on many factors, but clearly any form of nutritional stress, whether actual or secondary to the physiological de- mands, could have a direct bearing on the psychological stress observed in clinical prac- tice.Consequently maternal nutrition during this postnatal period should be a matter of high priority, especially where it may not have been possible to give adequate attention to this aspect during the last few weeks of pregnancy.-Weare, etc.,
Structure of the Personality in Psychotherapy
Authors: E. Kretschmer
Journal: BMJ (1937)

Medical treatment by psychological methods is governed by certain guiding conceptions. In the older psycho therapy the leading principle is that of suggestion ; in the more recent that of psycho-analysis. In neither is the study of the finer structure of the personality the aim. Suggestion can very well be practised as mass or group sug gestion ; in fact, frequently those suggestions are strongest and most effective which ignore the single individuality and bring it down to a common level. In the psycho analytical schools it is the problem of experiences, their elaboration, transformation, and after-effects, which is in the foreground ; the other Jialf, the inner structure of the personality which is influenced thereby, receives little atten tion. It is not at this moment my purpose to state my attitude to all these various methods of psychotherapy, but rather to tackle the problem for once from the opposite side, to show it in the light of the personality and its inner biology.
Autoantibodies against the second extracellular loop of beta1-adrenergic receptors predict ventricular tachycardia and sudden death in patients with idiopathic dilated cardiomyopathy
Authors: Michikado Iwata, Tsutomu Yoshikawa, Akiyasu Baba, Toshihisa Anzai, Hideo Mitamura, Satoshi Ogawa
Journal: Journal of the American College of Cardiology (2001)
Corrigendum: BBS10 encodes a vertebrate-specific chaperonin-like protein and is a major BBS locus
Authors: Corinne Stoetzel, Virginie Laurier, Erica E Davis, Jean Muller, Suzanne Rix, José L Badano, Carmen C Leitch, Nabiha Salem, Eliane Chouery, Sandra Corbani, Nadine Jalk, Serge Vicaire, Pierre Sarda, Christian Hamel, Didier Lacombe, Muriel Holder, Sylvie Odent, Susan Holder, Alice S Brooks, Nursel H Elcioglu, Eduardo D Silva, Béatrice Rossillion, Sabine Sigaudy, Thomy J L de Ravel, Richard Alan Lewis, Bruno Leheup, Alain Verloes, Patrizia Amati-Bonneau, André Mégarbané, Olivier Poch, Dominique Bonneau, Philip L Beales, Jean-Louis Mandel, Nicholas Katsanis, Hélène Dollfus
Journal: Nature Genetics (2006)
Regulation of gastric function by gastrin releasing peptide
Authors: I L P Beales
Journal: Gut (2002)

Hypomagnesaemia due to malabsorption is not always responsive to oral magnesium oxide supplementation aloneWe read with interest the Gut File report by Dr Ross and colleagues of hypomagnesaemia due to malabsorption, eventually responding to oral magnesium oxide supplementation (Gut 2001;48:857-8).Our experience however has been different.For the past seven years we have managed a 65 year old woman with short bowel syndrome (right hemicolectomy for Duke's C colorectal carcinoma and thereafter a terminal ileal resection for abscess formation).High ileostomy output was initially difficult to manage (after excluding infection, secreting gut hormone tumours by normal hormone levels, and despite dietary and pharmacological modifications).Clinical signs of hypomagnesaemia and hypocalcaemia ensued.An initial trial with magnesium glycerophosphate (September 1992 to December 1993) was insufficient to sustain her serum magnesium levels requiring frequent "top ups" of intravenous magnesium. 1In December 1993, she was switched to magnesium oxide supplementation but despite this the frequency of intravenous magnesium "top ups" were not reduced.Compliance was not deemed to be an issue with our patient.Since then we have managed this woman while still taking magnesium oxide supplements with almost 3-6 monthly (fig 1) intravenous magnesium replacement through a peripheral line and have avoided insertion of a Hickman line and all its associated complications. 2 While we agree that a trial of magnesium oxide is prudent and until the pharmacokinetics are better understood, this preparation may not be sufficient, especially in patients with extensive resection of the small bowel, as demonstrated in our patient.
Ascorbic acid treatment corrects the phenotype of a mouse model of Charcot-Marie-Tooth disease
Authors: Edith Passage, Jean Chrétien Norreel, Pauline Noack-Fraissignes, Véronique Sanguedolce, Josette Pizant, Xavier Thirion, Andrée Robaglia-Schlupp, Jean François Pellissier, Michel Fontés
Journal: Nature Medicine (2004)
A Case of Non-Union of Fracture of Both Bones of the Leg, of Eighteen Weeks' Standing, Successfully Treated by Mercury
Authors: R. Thursfield
Journal: BMJ (1851)

This case was six months and a half advanced.The child was living, and died in 28 hours.We have means now within our power, with which in former years we were unacquainted,-the ergot for instance; but perhaps there may have been unfortunate results from incautious use of it; and very satisfactory effects in many cases may, I think, be obtained more safely from opium.Mrs. O., in December last, is an example.
Collective Guilt-Reply
Authors: Gregory D. Curfman
Journal: JAMA (1991)

<h3>In Reply.—</h3> Dr Uhlich thoughtfully touches on a complex question known in Germany as the "historians' conflict" (<i>Historikerstreit</i>).<sup>1</sup>Namely, was the Holocaust unique among mass killings committed throughout history, or was it comparable to other national horrors (like African slavery or Stalin's purges)? Other troublesome questions follow from this one. If the mechanized extermination of nearly 6 million Jews by the Nazis is regarded as uniquely evil among genocides, then does this imply that the German "national character" is inherently flawed? Are Germans by their nature prone to committing heinous acts? Or, in a different vein, if we regard Auschwitz as just another example, among many, of man's inhumanity to man, are we thereby engaging in a form of Holocaust "revisionism" that attempts to exonerate the German people of a guilty sentence they rightly deserve? These difficult questions do not lend themselves to simple answers. My own opinions have
Youth Ignorance of HIV/AIDS
Authors: Joan Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Discovery of Leprosy Bacillus
Authors: Th. M. Vogelsang
Journal: JAMA (1963)

<h3>To the Editor:</h3> —In a letter of March 7, 1962, the medical director of the Leonard Wood Memorial (American Leprosy Foundation), James A. Doull, informs me that there are some discrepancies in the American textbooks and manuals concerning the date on which Armauer Hansen first observed the rod-shaped bodies in leprous nodules later known as<i>Mycobacterium leprae</i>(Hansen's bacillus). The date oscillates between 1868 and 1879. Since most of Hansen's publications are written in Norwegian, and very few of the authors of textbooks and manuals are able to read this language, it is understandable that there should be some misapprehension. To prevent these discrepancies from continuing in the future, I will give the following facts. In his first scientific paper in 1869, Hansen gave a description of the normal and pathological anatomy of lymph nodes. It was not printed until 1871.<sup>1</sup>In the material, information regarding some lymph nodes
Wound dressings composed of copper-doped borate bioactive glass microfibers stimulate angiogenesis and heal full-thickness skin defects in a rodent model
Authors: Shichang Zhao, Le Li, Hui Wang, Yadong Zhang, Xiangguo Cheng, Nai Zhou, Mohamed N. Rahaman, Zhongtang Liu, Wenhai Huang, Changqing Zhang
Journal: Biomaterials (2015)
Preparing for 2009 H1N1 Influenza
Authors: Richard P. Wenzel, Michael B. Edmond
Journal: New England Journal of Medicine (2009)

In 1743, when disease was presumed to be astral in origin, European newspapers reported on a contagious influence (influenza in Italian) that was being visited on the citizens of Rome. Two hundred years later, Wilson Smith and colleagues would isolate an influenza A virus, one of the members of the orthomyxovirus family.1 The key reservoirs of all influenza A viruses are migrating waterfowl, and intermittently, other hosts, such as pigs and people, are infected. Further classification of influenza A viruses is based on the specific hemagglutinin viral attachment spike and neuraminidase disengagement spike; the latter is cleaved when newly . . .
TECHNIC OF TONSILLECTOMY
Authors: GEORGE L. RICHARDS
Journal: JAMA (1913)

During the last few years an enormous amount of literature has been written concerning the operation of tonsillectomy, most of which has been occupied with trivial details either of position, instrumentation or order of procedure. If general surgery were to occupy itself with so many minor details for each operation the literature of operative techic would be overwhelming. It seems to me time to simplify somewhat our literature of this subject, and describe principles rather than minute details. The tonsil is a gland set in each side of the back of the mouth; bounded in front by the palatoglossus muscle or anterior pillar, behind by the palatopharyngeus muscle or posterior pillar, and externally and somewhat above by the superior constrictor muscle, and inferiorly lying against the root of the tongue. It is embraced, except on its free surface, with a fibrous capsule, and this fibrous capsule is attached to the
Partial awareness and the illusion of phenomenal consciousness
Authors: Sid Kouider, Vincent de Gardelle, Emmanuel Dupoux
Journal: Behavioral and Brain Sciences (2007)

Abstract The dissociation Block provides between phenomenal and access consciousness (P-consciousness and A-consciousness) captures much of our intuition about conscious experience. However, it raises a major methodological puzzle, and is not uniquely supported by the empirical evidence. We provide an alternative interpretation based on the notion of levels of representation and partial awareness.
Comparison of Reticuloendothelial Scans with Bone Scans in Malignant Disease
Authors: DAVID P. SHREINER, YINGCHIEH HSU
Journal: Clinical Nuclear Medicine (1981)

Thirty patients with histologically proven malignant disease were selected for reticuloendothelial scans and bone scans because of suspected bone or bone marrow involvement. Reticuloendothelial scans were abnormal in 83% of the patients and bone scans were abnormal in 47%. Focal defects on the reticuloendothelial marrow scan correlated better with tumor infiltration of the marrow than did diffusely abnormal scans. Focal defects were found in nine patients (30% of total), four of whom had negative or equivocal bone scans. In multiple myeloma, reticuloendothelial marrow scans were more sensitive than bone scans, but were not clearly better than bone scans in patients with solid tumors. In the interpretation of reticuloendothelial scans, consideration must be given to the effects of radiation, chemotherapy, and uremia, all of which may cause decreased reticuloendothelial uptake and falsely positive reticuloendothelial scans. Reticuloendothelial scans seem most useful for hematologic malignancies that have not been previously treated. The advantages and disadvantages of reticuloendothelial scans are discussed.
Cardiopulmonary Data for Children and Young Adults
Authors: Dean Crocker
Journal: JAMA (1962)

The book consists of a series of physiological values in tabular form obtained from laboratory studies performed at the University of Chicago. Nine topics are presented: Heart rate and blood pressure; blood and plasma volume; hemoglobin concentration and oxygenation; carbon dioxide and pH values of arterial and venous blood and plasma; electrolyte concentrations of plasma and the effect of exercise on electrolytes; selected respiratory data; and maximum breathing capacity. Data obtained from patients with congenital heart disease and kyphoscoliosis are also presented. The last 2 chapters include tables of electrocardiographic changes during exercise and studies of peripheral blood flow in children. This cannot be regarded as a complete handbook of cardiopulmonary data, nor do the authors intend it to be so. The fact that all investigation was carried out in one laboratory under the same supervision lends greater significance to the results. Although identical figures may not be obtained by
Abstract 4642: Biomarkers for assessment of tissue quality in cancer research
Authors: Jie Li, Arianne Eason, Alexander Vortmeyer
Journal: Cancer Research (2011)

Abstract Objectives: Much of the progress in molecular cancer research would not have been achieved without access to clinical tissue specimens. However, lack of quality control on these specimens frequently leads to the generation of irreproducible research data, especially when archived samples of uncertain quality are utilized. We hypothesized that biomolecules have different susceptibility to decomposition and that susceptible molecules may serve as indicators to reveal the molecular quality of tissue. We seek to use a proteomic approach to evaluate protein decomposition over time at room temperature (RT) and to mathematically coordinate the extent of decomposition with the RT-exposure time length. This decomposition curve will serve for tissue-quality assessment. Materials and methods: Cultured cells were used for primary biomarker-screening. Cell origins included kidney (293T), prostate (LNCaP), breast (MDA-MB-231), blood (Jurkat), and lymphoma (Namalwa). Aliquots of cells were randomly assigned to immediate flash-freezing or exposure to RT for 0.5, 4, 8, 24, 48 hours. Lysates were applied in duplicate to Two-Dimensional Fluorescence Difference Gel Electrophoresis (2D DIGE) with pH 3-10 IPG strips and large format PAGE. Proteomic comparison was performed using Decyder software with embedded paired t-/ANOVA-analysis. Spots, consistent in repeats with statistical significance between groups, were sequenced with both LC/MS/MS and MALDI-TOF. Clinical specimens (n=3 for each corresponding organs), procured as above, were used for biomarker validation via regular Western blot and 2-D/IPG-strip Western blot. Results: 2D-DIGE revealed ∼3000 spots per gel. During the course of exposure to RT, proteomic patterns exhibited dynamic and time-dependent changes in specific subsets of proteins, starting from 0.5 hour. The alterations revealed on 2D-DIGE were changes in molecular weight and/or isoelectric point; the results were validated via Western blot and 2-D/IPG-strip Western blot, respectively. Protein candidates that decomposed in a time-dependent manner allowed for the generation of regression curves using the protein quantity against corresponding time points. Several of above proteins, mostly housekeeping proteins, behaved consistently across all types of observed cell/specimen. Therefore, they could serve as widely applicable biomarkers for indication of exposure time (to RT) and further for assessment of the molecular quality of research specimens. Conclusions: The study will draw peers’ attention on the molecular quality of their research tissue and offer biomarkers for the quality assessment. Based on the assessment result, the meaning of tissue-research data should be reinterpreted accordingly. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4642. doi:10.1158/1538-7445.AM2011-4642
The Ausculatory Gap in Arteriosclerotic Heart Disease
Authors: SIMON RODBARD, JACK MARGOLIS
Journal: Circulation (1957)

Auscultatory gaps, found in some patients with arteriosclerotic heart disease, can be elicited in others by reducing blood flow in the extremity. Reactive hyperemia eliminates the gap in every instance. The gap therefore appears to represent a vasospastic disturbance that limits the blood flow to the extremities, despite the presence of an enhanced pressure head.
T- and B-Cell Distribution in Pregnancy
Authors: James R. Scott, Thomas L. Feldbush
Journal: JAMA (1978)

We established the percentage of thymus-derived lymphocytes associated with cellular immune responses and bone marrow-derived, antibody-producing cells in maternal blood throughout normal gestation. The data are in conflict with a recent proposal that reversal ot the T:B cell ratio associated with the serum human chorionic gonadotrophin peak of early pregnancy assists in fetoplacental allograft acceptance. Moreover, variability on lymphocyte dynamics in four women followed up serially throughout pregnancy, as well as T- and B-cell determinations in 15 patients whose pregnancy complications are potentially related to maternal-fetal immunologic aberrations, suggests that more sensitive immunologic methods of monitoring the host immune response are necessary to be clinically useful in obstetrics.