tbuckley/cabot-search huggingface dataset:
Amiodarone pneumonitis: three further cases with a review of published reports.
Authors: J I Darmanata, N van Zandwijk, D R Duren, E A van Royen, W J Mooi, T A Plomp, H M Jansen, D Durrer
Journal: Thorax (1984)

Three further patients are presented who developed evidence of a parenchymal pulmonary disturbance in the course of treatment with amiodarone. In one case the progress of the condition was rapid and ended fatally. Histological examination of the lungs showed evidence of diffuse alveolar damage. The concentration of amiodarone was from four to seven times higher in the lungs than in other organs studied. The concentration of the metabolite desethylamiodarone in the lungs was even higher in relation to other organs studied. The remaining two patients showed a more insidious onset and improvement after withdrawal of amiodarone and treatment with corticosteroids. Gallium 67 scintigraphy appeared to be a sensitive indicator of this adverse effect. Review of published reports revealed 35 cases of amiodarone pneumonitis, including the cases reported in this study. In 11 instances the dose of amiodarone was 400 mg or less. The onset was either insidious or rapidly progressive. Exertional dyspnoea was always present and a nonproductive cough, hypoxaemia, a raised erythrocyte sedimentation rate and diminished carbon monoxide diffusing capacity (transfer factor) were usually noted. Chest radiographs showed either a reticular pattern or diffuse patchy alveolar infiltrates. Discontinuation of amiodarone and an institution of corticosteroid treatment was usually followed by improvement or resolution.
Amoebiasis in homosexual men.
Authors: A McMillan, H M Gilmour, G McNeillage, G R Scott
Journal: Gut (1984)

<b>Objectives:</b> To examine the change in health-related quality of life (HRQOL) and its determinants in children with juvenile idiopathic arthritis (JIA) treated with methotrexate (MTX). <b>Methods:</b> Patients were extracted from the PRINTO clinical trial aimed to evaluate the efficacy and safety profile of MTX administered in standard, intermediate or higher doses (10, 15 and 30 mg/m2/week respectively). Children with polyarticular-course JIA, who were less than 18 years and had a complete HRQOL assessment were included. <b>Results:</b> A total of 521 children were included. At baseline, JIA patients showed poorer HRQOL (p&lt;0.01) as compared to healthy children. In 207/412 (50%) and 63 (15%) children, HRQOL values were 2 standard deviation from the mean of healthy controls in the physical and psychosocial summary scale, respectively. After 6 months of therapy with standard-dose MTX, there was a statistical significant improvement in all HRQOL health concepts, particularly in the physical ones. Similar improvements were observed in the patients non-responders to standard dose MTX who were subsequently randomized to higher dose-MTX. The presence of marked disability at baseline was associated with a 5-fold increased risk to maintain a poor physical health after 6 months of active treatment with standard-dose MTX. Other less important determinants for maintenance of poor physical well being were the baseline level of systemic inflammation, the intensity of child's pain and an ANA-negative status. <b>Conclusions:</b> We report that MTX treatment produces a significant improvement across a wide range of HRQOL components, particularly in the physical domains, in patients with JIA.
HBV-core antibody as unique serological evidence of chronic hepatitis B in patients with renal failure under chronic dialysis in an renal transplant program
Authors: Ana M. Contreras, Francisco J. Monteon, Sara Ruelas, Gonzalo Vazquez, Luis Suarez, Jesus E. Garcia, Sergio Aguilar, Cecilia Vivas, Patricia Romero, Ma.Teresa Vazquez
Journal: Journal of Hepatology (2002)
When laughing is scarce
Authors: Eric Mackay
Journal: BMJ (2005)

Many practices contain one or two safebreakers, known or incognito. At our practice, however, we had a genuine safe salesman, who had spent his working life in a quiet advisory capacity defending individuals and firms against the assaults of crime. He was a gentle, thoughtful man with a twinkle in his eye and for many years had been session clerk to a …
Increasing access to psychological therapies will cost NHS nothing, says report
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Provision of treatment for people with mental illness in England needs to expand urgently to “remedy a gross inequality” whereby people with physical symptoms are four times as likely to get treatment as people who have mental health problems, says a report from the London School of Economics and Political Science (LSE).1

Nearly half of all ill health among people under 65 is due to mental illness, yet only a quarter of them get treatment, says the report by the Mental Health Policy Group, a team of economists, psychologists, doctors, and NHS managers convened by the economics professor Richard Layard, programme director at the LSE’s Centre for Economic Performance.

Investing more money in treating mental illness would cost the NHS nothing …
Hepatocytic phenotypes induced in sarcomatous cholangiocarcinoma cells treated with 5-azacytidine
Authors: M Enjoji, M Nakashima, M Honda, H Sakai, H Nawata
Journal: Hepatology (1997)

The sarcomatoid cells found in cholangiocarcinoma (CC) or hepatocellular carcinoma (HCC) are not well characterized. In this study, a human sarcomatoid CC cell line, ETK-1, was established from a patient, and then morphological and phenotypical characteristics of the ETK-1 cells were evaluated before and after treatment with differentiation-inducing 5-azacytidine (5-azaCR). Phenotypically, the ETK-1 cells appeared immature. Exposure to 5-azaCR induced morphological transformation; a converted cell line, MEK, was successfully established. The MEK cells expressed such hepatocyte-specific proteins as alpha-fetoprotein, albumin, integrin alpha1, and thrombopoietin, but lost such bile duct-specific proteins as integrin alpha3 and integrin beta4. The histopathology of MEK xenografts resembled that of HCC. The ETK-1 cells appeared to be converted into hepatocytes by exposure to 5-azaCR. On the other hand, ETK-1 xenografts were diagnosed as tubular adenocarcinoma, and the tumor cells had a ductal phenotype. This suggests the possibility that ETK-1 cells can differentiate along a biliary epithelial cell lineage. ETK-1 and MEK will be useful in studying hepatocytic differentiation and the transformation from a biliary epithelial cell to a hepatocytic lineage.
P76 When Is It Safe To Discharge Resected Stage 1a/1b Nsclc From The Clinic?
Authors: G. Kamalatharan, C. Moorcroft, R. Shah, S. Taggart
Journal: Thorax (2014)

<h3>Introduction</h3> We have previously shown that the majority of recurrent disease occurs within the 2 years of lung cancer resection.<sup>1</sup> Follow-up protocols vary between centres but often involve serial CXR examinations. At Salford we also perform a CT scan at one year after surgery. Given that the prognosis for early stage lung cancer is good, the question arises as to when it’s safe to discharge such patients from follow-up? Traditionally this has been set at 5 years. The Salford Lung Cancer d-base provides comprehensive data on all patients in Salford undergoing surgical resection including outcomes during follow-up. To date, 255 patients have undergone resection of non-small cell lung cancer and the rate of resection is increasing year on year.<sup>2</sup> This audit sets out to review the data following introduction of routine PET scans to our service in 2005 with a view to providing guidance as to when it might be safe to discontinue regular follow-up of early stage disease. <h3>Methods</h3> All patients undergoing surgical resection were first identified from March 2006 to July 2010. Those with a post-operative stage 1A or 1B disease were then extracted; allowing a 4 year follow up for each patient. Those patients dying within 4 years of surgery from non-cancer and non-lung cancer causes were excluded to produce a selected cohort of patients. 1, 2, 3 and 4 years survival figures were then produced for each category of disease (1A, 1B and 1A+1B) to observe for any serial changes. <h3>Results</h3> A total of 89 patients underwent surgical resection during the study period of which 55 (62%) were 1A or 1B disease. After exclusions, 43 patients (23 × 1A and 20 × 1B) were available for analysis. As expected, relapse rates were low and occurred in the first 2 years. Survival rates were high but remained stable after 2 years of follow up (see Table). The use of 1 year CT scans detected just 2 relapses. <h3>Conclusions</h3> Allowing for the small numbers, the above audit supports a move away from traditional follow-up protocols to discharge alive and well patients with resected early stage disease from the clinic at 2 years. The role of imaging surveillance during the first 2 years requires further exploration. <h3>References</h3> Tunney R <i>et al</i>. P195 Temporal Trends and Distribution of Recurrent Disease Following Lung Cancer Surgery and Relationship to Pre-Operative PET-CT. Thorax 2010;65:A159–A160 Gornasa M <i>et al</i>. P7 Radical Treatments for Lung Cancer: Impact of Recent Service Improvements. Thorax 2013;68:A77–78
960. Gene-Based Delivery of Interferon-beta Is Efficacious in a Murine Model of Acute Experimental Allergic Encephalomyelitis
Authors: Caralee Schaefer, Toni Rose Arceo, Paul Szymanski, Hu Sheng Qian, Heather Gibson, Harald Petry, Claudia Goldman, Linda Cashion, Alan Brooks, Cynthia Gross, Peiyin Wang, Gabor M. Rubanyi, Richard N. Harkins
Journal: Molecular Therapy (2005)

Experimental Allergic Encephalomyelitis (EAE) is a model of central nervous system (CNS) inflammation that ensues following immunization with certain CNS antigens, for example brain derived proteolipid or myelin basic protein. The course and clinical manifestations of EAE are similar to multiple sclerosis (MS) in humans and it has become an accepted animal model to study MS. There have been several reports in which Interferon-beta (IFN-b) protein has been shown to be effective in murine and rat models of EAE. It has also been shown that local CNS delivery of a plasmid DNA encoding IFN-b decreased the severity of the disease. The purpose of this study was to demonstrate that systemic expression of murine IFN-b (mIFN-b) following gene-based delivery of plasmid DNA to hind limb skeletal muscle is effective in reducing the clinical manifestations of disease in a rodent EAE model.
Effects of lazaroid U-74389G on intestinal ischemia and reperfusion injury in porcine experimental model
Authors: Ioannis Flessas, Ioannis Bramis, Evangelos Menenakos, Konstantinos Toutouzas, George Agrogiannis, Efstratios Patsouris, Afroditi Nonni, Dimosthenis Chrysikos, Maria Korontzi, Aristea Gioxari, George Zografos, Apostolos Papalois
Journal: International Journal of Surgery (2014)
Inhalation challenge testing of latex-sensitive health care workers and the effectiveness of laminar flow HEPA–filtered helmets in reducing rhinoconjunctival and asthmatic reactions☆☆☆★★★
Authors: Nunthaporn Laoprasert, Mark C. Swanson, Richard T. Jones, Darrell R. Schroeder, John W. Yunginger
Journal: Journal of Allergy and Clinical Immunology (1998)
The Information Content from Renal Biopsy in Systemic Lupus Erythematosus
Authors: Q. WHITING-O'KEEFE
Journal: Annals of Internal Medicine (1982)

We analyzed data for the 12-month period after renal biopsy was done in 130 patients with systemic lupus erythematosus to examine whether renal biopsy provides useful information on the nephritis of systemic lupus erythematosus beyond that clinically available. A stepwise linear regression analysis was used to construct a linear before biopsy model that predicted the change in renal function 12 months after biopsy. The model included serum creatinine, patient age, 24-hour urine protein, a laboratory index of renal activity, antibodies to DNA, urinalysis protein, change in inverse creatinine from 6 weeks before biopsy, and urine light chain protein, and had a squared multiple correlation coefficient (R2) of 0.246. Four prospectively chosen renal biopsy variables (glomerular cell counts, percent of sclerotic glomeruli, percent of glomeruli with crescents, and interstitial fibrosis) resulted in a 0.079 improvement in R2 (p < 0.012). Both the percent glomerular sclerosis (p < 0.0032) and subendothelial deposits shown by electron microscopy (p < 0.0026) added significantly to the predictive power of the before biopsy model. Histologic classification did not add significantly to the before biopsy model. The renal biopsy information increased the power of a linear regression model to predict the effect of 12 months of treatment of active lupus nephritis.
Multinodular Goiter With a Huge Infected Cyst
Authors: CHUNG-YUAN HSU, CHIA-HUNG KAO, SHYH-JEN WANG
Journal: Clinical Nuclear Medicine (1994)

A 71-year-old female aborigine in Taiwan suffered from chills, fever, tenderness, and progressive enlargement of goiter. Tc-99m thyroid and Ga-67 scans revealed a huge ovoid shape photon-deficient mass and increased uptake around the mass, respectively. Aspiration of the huge cyst produced blood-stained pus from which Staphylococcus aureus was isolated. Operative findings revealed a huge cyst from the left lobe of the thyroid in a multinodular goiter.
Abstract 3524: A novel approach to targeting mutated colorectal adenocarcinomas with T cell-engaging CEA/CD3-bispecific BiTE investigational antibody MEDI-565
Authors: Michael D. Oberst, Stacy Fuhrmann, Kathy Mulgrew, Maria Amman, Lily Cheng, Petra Lutterbuese, Laura Richman, Steven Coats, Patrick A. Baeuerle, Scott A. Hammond
Journal: Cancer Research (2012)

Abstract Colorectal cancer (CRC) cells can harbor somatic mutations with strong impact on cancer cell signaling that limit the effectiveness of both chemotherapy and targeted therapies including monoclonal antibodies and kinase inhibitors. Therefore, novel therapeutic modalities are needed that are not impacted by the presence of such genetic mutations. We have here evaluated a CEA/ CD3-bispecific BiTE antibody termed MEDI-565 (also known as MT111) for its ability to redirect cytotoxic T cells for lysis in co-cultures and in xenograft models of human CRC lines harboring oncogenic mutations. Redirected lysis of CEA-positive tumor cells by MEDI-565 occurred in a manner dependent on CEA surface antigen density but independent of exogenously added soluble CEA. Importantly, the potency of lysis was independent of the mutational status of genes commonly mutated or lost in colorectal and other cancers, including frequent mutations in KRAS, BRAF, PI3KCA, PTEN and TP53 genes. In mouse xenograft models, the ability of MEDI-565 to inhibit tumor growth was likewise independent of the mutational status of the human tumor xenograft models. Our findings suggest that MEDI-565 warrants further clinical investigation as a potential treatment option for patients with CEA-positive tumors harboring somatic mutations that are less responsive to traditional chemotherapy or targeted agents. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3524. doi:1538-7445.AM2012-3524
Angiokeratoma Corporis Diffusum—A Case Report
Authors: Hiram B. Curry
Journal: JAMA (1961)

The case of angiokeratoma corporis diffusum here described is believed to be the fifth reported in this country. The patient, a Caucasoid man, was admitted to the hospital at the age of 23 years, with a neurological finding of left hemianesthesia. The dermatological symptoms had appeared at the age of 18 months in the form of many dark red, non-blanching, verrucous papules measuring from 0.5 to 4 mm. in diameter. They became larger, darker, and more numerous during his childhood. Their angiokeratomatous nature was recognized at biopsy. The underlying pathology is a thickening of arterial walls, the muscle cells of the tunica media being enlarged. Since the cardiovascular, renal, respiratory, and nervous systems all become involved, the symptoms are varied. The prognosis is poor, and the cause is unknown.
Cranial Ultrasonography of Infants
Authors: Leonard J. Graziani
Journal: JAMA (1982)

The purpose of this well-illustrated, relatively lengthy (246 pages, including index) text is to acquaint clinicians caring for infants with the uses, advantages, and capabilities of B-mode cranial ultrasonography and to share the experience and knowledge gained by the authors over a three-year period with those radiologists, ultrasonographers, and clinicians interested in cranial ultrasonography. The result achieves the authors' goals and offers a practical and introductory text on B-mode cranial ultrasonography. Recent technical advances in ultrasound equipment have resulted in numerous publications of cranial ultrasonographic studies in neonatal infants, the bulk of which involve preterm neonates who are at risk for intracranial and intraventricular hemorrhage. Ultrasound images in the coronal and sagittal plane obtained by scanning through the anterior fontanelle are particularly well suited for study of intracranial hemorrhage in neonatal infants and are a great advance in partially understanding what is now recognized as a major problem in the
281 INTRAHEPATIC ULTRASOUND-MEDIATED GENE DELIVERY
Authors: O.K. Toporova, D.M. Irodov, R.V. Bubnov, O.L. Kholodkova, T.P. Gulko, T.P. Ruban, P.V. Morgunov, V.A. Kordium
Journal: Journal of Hepatology (2013)
IMMUNOLOGY OF THE PERUVIAN STRAINS OF LEPTOSPIRA ICTEROIDES
Authors: Hideyo Noguchi, I. J. Kligler
Journal: The Journal of Experimental Medicine (1921)

Serum from yellow fever convalescents from Payta, Piura, and Morropon gave a positive Pfeiffer reaction with the strains of Leptospira icteroides isolated in Guayaquil and Merida. The serum also protected the guinea pigs from these strains in the majority of instances. The Pfeiffer reaction was complete with all recent convalescents (7 to 36 days) but slight or partial in some instances with serum derived from individuals who had had the attack of yellow fever 10 months previously. The virulence of the Morropon strains was found to be approximately the same as that of the Guayaquil or Merida strains. With one strain the minimum lethal dose for the guinea pig was less than 0.00001 cc. of a kidney emulsion from an infected guinea pig. Suitable quantities of the anti-icteroides serum administered to guinea pigs inoculated with 2,000 to 20,000 minimum lethal doses of infective material prevented the development of the infection, or a fatal outcome, according as the serum was given during the incubation period or after fever had appeared. The earlier the administration of the serum the smaller was the quantity needed; during the incubation period 0.0001 to 0.001 cc. was sufficient, during the febrile period 0.01 to 0.1 cc. was required to check the progress of the disease, and even at the time when jaundice had already appeared, the injection of 0.1 to 1 cc. saved three out of four animals inoculated with Strain 3 and one out of three inoculated with Strain 1. The native guinea pigs secured in Payta proved to be unusually refractory to infection with Leptospira icteroides as compared with normal guinea pigs recently imported from New York. Fresh rabbit serum is recommended for culture work with Leptospira icteroides.
THE SCARLET FEVER TOXIN AND THE DICK TEST
Authors: P. S. ROSEN
Journal: JAMA (1925)

The work of the Dicks and of Zingher on scarlet fever, reported from time to time inThe Journal, is of great theoretical and practical importance. We have tried to repeat some of it. The toxicogenic properties of nine strains of hemolytic streptococcus, obtained from the throats of scarlet fever patients in the first days of illness, were examined. Seven of them were found to be producers of toxin. In preparing the toxin, we have used the broth of fermented meat with 2 per cent. Witte's peptone with an alkalinity of<i>p</i>H7.8. Five per cent. citrated or defibrinated sheep's blood was added to the broth. After incubation for four days at 37 C., the toxin was filtered through filter paper, and 0.25 per cent. phenol (carbolic acid) was added to it. The strength of the first portions of our toxin was 1:250, and later 1:500. At our disposal
Aetiology of Complete Heart-block
Authors: M. Zoob, K. S. Smith
Journal: BMJ (1963)

That complete heart-block in the elderly is often due to coronary sclerosis has been, and still is, very widely assumed.The prevalence of coronary heart disease in the later decades of life, when such block commonly occurs, and the occasional appearance of complete heart-block in cardiac infarction have lent colour to this assumption.Moreover, the weighty affirmations of earlier authors have tended to discourage a critical attitude in this matter.The purpose of the present paper is to study the aetiology of complete heart-block and in particular to weigh the evidence upon which this disorder has been attributed to coronary disease.It is well first to review earlier relevant publications (Table I).
Transplants from live patients scrutinised after donor's death
Authors: D. Josefson
Journal: BMJ (2002)

Liver transplants from live donors are under increased scrutiny in the United States after the death of a previously healthy 57 year old man who donated a portion of his liver to save an ailing brother from fatal liver failure.

The man, Michael Hurewitz, a former reporter on the New York Post and the Times Union of Albany, volunteered to have a portion of his liver removed and transplanted into his brother, 54 year old Adam Hurewitz, a doctor. The operation and postoperative care were performed …
ANATOMY OF PERIPHERAL SENSATION
Authors: H. H. Woollard
Journal: BMJ (1936)

I-Ic JUBRISL 861 failed because of defective eyesight.Correction by glasses remedied this defect, and on being asked what was the matter with his neck he told the examining doctor that it was a " bit stiff."No detailed examination was made, and he was passed for training.This was completed, and for the last fourteen years he has carried out his work as a van salesman, starting and driving his van and loading and delivering packages hirmself.