tbuckley/cabot-search huggingface dataset:
Right ventricular reserve in a piglet model of chronic pulmonary hypertension
Authors: Julien Guihaire, François Haddad, Pierre-Emmanuel Noly, David Boulate, Benoit Decante, Philippe Dartevelle, Marc Humbert, Jean-Philippe Verhoye, Olaf Mercier, Elie Fadel
Journal: European Respiratory Journal (2014)

Right ventricular (RV) response to exercise or pharmacological stress is not well documented in pulmonary hypertension (PH). We investigated the relationship between RV reserve and ventricular–arterial coupling. Surgical ligation of the left pulmonary artery was performed in 13 Large White piglets (PH group), thereafter weekly embolisations of the right lower lobe were performed for 5 weeks. A control group of six piglets underwent sham procedures. Right heart catheterisation and echocardiography were performed at week 6. Pressure–volume loops were recorded before and after dobutamine infusion. Induction of experimental PH resulted in a higher mean± sd pulmonary artery pressure (34±9 versus 14±2 mmHg; p&lt;0.01) and in a lower ventricular–arterial coupling efficiency (0.66±0.18 versus 1.24±0.17; p&lt;0.01) compared with controls at 6 weeks. Dobutamine-induced relative changes in RV stroke volume index (SVI) and end-systolic elastance were lower in the PH group (mean± sd 47±5% versus 20±5%, p&lt;0.01, and 81±37% versus 32±14%, p&lt;0.01, respectively). Change in SVI was strongly associated with resting ventricular–arterial coupling (R 2 =0.74; p&lt;0.01). RV reserve was associated with ventricular–arterial coupling in a porcine model of chronic pressure overload.
Heart valve changes common to man and dog: a comparative study
Authors: A. Pomerance, J. C. Whitney
Journal: Cardiovascular Research (1970)

Journal Article Heart valve changes common to man and dog: a comparative study Get access Ariela Pomerance, Ariela Pomerance 1 From the Histopathology Department, Central Middlesex Hospital, London, and the Department of Veterinary Pathology (Royal Dick) School of Veterinary Studies, University of Edinburgh 1 In receipt of a grant from the British Heart Foundation. Search for other works by this author on: Oxford Academic PubMed Google Scholar John C. Whitney John C. Whitney From the Histopathology Department, Central Middlesex Hospital, London, and the Department of Veterinary Pathology (Royal Dick) School of Veterinary Studies, University of Edinburgh Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 4, Issue 1, January 1970, Pages 61–66, https://doi.org/10.1093/cvr/4.1.61 Published: 01 January 1970 Article history Accepted: 24 March 1969 Published: 01 January 1970
Rapidly Progressive, Fatal Pulmonary Fibrosis Induced by Carmustine
Authors: Gregg A. Patten, John E. Billi, Harold H. Rotman
Journal: JAMA (1980)

CARMUSTINE (BCNU), one of a new class of anticancer drugs, is employed in the combination treatment of several malignant conditions and as a single agent in the treatment of CNS malignant diseases.<sup>1,2</sup>There have been several reports of pulmonary toxicity in drug regimens including carmustine,<sup>3,4</sup>but only a few cases where carmustine was the only cytotoxic drug employed.<sup>1,5</sup>There have been no reported instances, to our knowledge, of carmustine toxicity occurring after a low dose of carmustine alone, after a short latent interval, and occurring as the adult respiratory distress syndrome (ARDS). We report here a case of rapidly progressive fatal pulmonary fibrosis, presenting as ARDS, in a patient who received a short course of carmustine as the sole antineoplastic agent. <h3>Report of a Case</h3> A 54-year-old woman noticed fatigue and left arm weakness, followed by a grand mal seizure in August 1978. In November, left arm
TV: The Human Face
Authors: N. Ali
Journal: BMJ (2001)

BBC1, Wednesdays at 9 10 pm, 7 to 28 March

The face serves many important functions, ranging from supporting the airway and the organs of special sense through to forming the most distinctive aspect of our personality. Since society began, facial appearance has been important. Psychologically, the concept of beauty and ugliness can result in a variety of psychiatric conditions, while abnormal development, trauma, cancer, or surgery affecting the face can cause considerable physical and psychological morbidity. Socially, discrimination based on facial appearance occurs in both workplace and classroom. The human face is therefore of great interest—as Cicero said, “everything is in the face.”

The Radio Times described The Human Face as the …
Progressive Disease Due to Ganciclovir-Resistant Cytomegalovirus in Immunocompromised Patients
Authors: Alejo Erice, Sunwen Chou, Karen K. Biron, Sylvia C. Stanat, Henry H. Balfour, M. Colin Jordan
Journal: New England Journal of Medicine (1989)

CYTOMEGALOVIRUS (CMV) infections are a major cause of morbidity and mortality among immunocompromised patients, especially recipients of bone marrow and solid-organ transplants and those with the acquired immunodeficiency syndrome (AIDS).1 2 3 4 More than 90 percent of patients with AIDS are infected with CMV,4 and there is evidence of disseminated CMV at autopsy in 93 percent of this patient population.5 Ganciclovir (9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine) has been studied in preliminary clinical trials for the treatment of severe CMV disease in immunocompromised patients.6 7 8 9 10 11 12 13 14 15 16 17 Although all studies have been uncontrolled, ganciclovir appears to be beneficial in CMV retinitis and in CMV involvement of the gastrointestinal . . .
Physicians' Attitudes about Patients in the Persistent Vegetative State
Authors: William W. Stead
Journal: Annals of Internal Medicine (1997)

Letters1 January 1997Physicians' Attitudes about Patients in the Persistent Vegetative StateWilliam W. Stead, MDWilliam W. Stead, MDArkansas Department of Health; Little Rock, AR 72205-3867Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-1-199701010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was pleased to see the article [1] and accompanying editorial [2] on the PVS. The paper by Gilligan and Raffin [3] and the essay by Dr. Hansot [4] brought to mind personal experiences with two older sisters, one of whom remained in a PVS for 5 years. During that time, the nursing home insisted on maintaining the flickering flame of life. Her living will and a letter from her long-time personal physician were ignored. They relented shortly after she qualified for Medicaid.The other sister was on a respirator because of end-stage chronic obstructive pulmonary disease ...References1. Payne K, Taylor RM, Stocking C, Sachs GA. Physicians' attitudes about the care of patients in the persistent vegetative state: a national survey. Ann Intern Med. 1996; 125:104-10. Google Scholar2. Cassell EJ. Clinical incoherence about persons: the problem of the persistent vegetative state [Editorial]. Ann Intern Med. 1996; 125:146-7. Google Scholar3. Gilligan T, Raffin TA. Whose death is it, anyway? Ann Intern Med. 1996; 125:137-41. Google Scholar4. Hansot E. A letter from a patient's daughter. Ann Intern Med. 1996; 125:149-51. Google Scholar Author, Article, and Disclosure InformationAffiliations: Arkansas Department of Health; Little Rock, AR 72205-3867 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1997Volume 126, Issue 1Page: 90KeywordsChronic obstructive pulmonary diseaseGeriatricsLiving willsNursing homesPersistent vegetative statePulmonary diseasesVentilators Issue Published: 1 January 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
A Clinical Lecture ON SUBCUTANEOUS RUPTURE OF THE INTESTINE: Given at Guy's Hospital on March 7th, 1923
Authors: R. P. Rowlands
Journal: BMJ (1923)

K raM J°p rolonged period of hypoglyeacmia -maaintained by slow absorption.The results also suggest that advantage might be taken of this metlhod to utilize crude insulin extracts.At tlle present time the cost of isolating the drug in a pure and active state for the purposes of lhypodermic medication is suclh as to restrict seriously its application on a large scale.It is possible that more liberal use of cruder materials mighit with advantage be made by means of iuunction.I have to thank Mr. Orr for performing the analyses of the blood.
THE USE OF PRECIPITIN ANALYSIS IN AGAR FOR THE STUDY OF HUMAN STREPTOCOCCAL INFECTIONS
Authors: Seymour P. Halbert, Lois Swick, Constance Sonn
Journal: The Journal of Experimental Medicine (1955)

Using a highly concentrated and partially purified streptolysin O preparation, migrating agar precipitins have been found in 94 of 143 human sera from patients with a variety of diseases. Most of those showing no bands, had very low antistreptolysin titers. A correlation was found between the migration rates of these bands and the antistreptolysin titer. A strong trend toward a straight line relationship was apparent when the ASO titers were plotted on a logarithmic scale. In addition, a roughly positive correlation was found between the intensity of these bands and the antistreptolysin O titers. The finding of high levels of antistreptolysin O activity and slowly migrating heavy bands in normal pooled human gamma globulin supported the above observations. Very similar results were obtained with rabbit and guinea pig sera after immunization with the streptolysin O concentrates. The data strongly indicate that antistreptolysin O activity in human sera is generally due to precipitating antibody, and that non-specific inhibitors are not usually involved, even with low titered sera. Rabbit and guinea pig antisera to the oxidized inactive and to the reduced active forms of streptolysin O showed no obvious differences. Attempts to demonstrate immunological differences between the two states of streptolysin were apparently complicated by proteolysis, due to contamination of the concentrates with proteinase precursor.
Autoritäts- und Freiheitsprobleme in den psychotherapeutischen Bedingungen unserer Gesellschaft
Authors: Vladeta Jerotic
Journal: Psychotherapy and Psychosomatics (1974)

Research Articles| February 12 2010 Autoritäts- und Freiheitsprobleme in den psychotherapeutischen Bedingungen unserer Gesellschaft Subject Area: Psychiatry and Psychology Vladeta Jerotic Vladeta Jerotic A. Krankenhaus "Dr. D. Mišović", Beograd Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1974) 24 (4-6): 412–418. https://doi.org/10.1159/000286776 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Vladeta Jerotic; Autoritäts- und Freiheitsprobleme in den psychotherapeutischen Bedingungen unserer Gesellschaft. Psychother Psychosom 31 December 1974; 24 (4-6): 412–418. https://doi.org/10.1159/000286776 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1974Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Is There Still Too Much Extrapolation From Data on Middle-aged White Men?
Authors: Paul Cotton
Journal: JAMA (1990)

A MYOPIC VIEW of confounding factors in clinical research is continuing to confound clinical practice. Efforts to streamline studies by using the most homogeneous population possible have filled medical libraries with data on middle-aged white men. Even female rats are commonly excluded from basic research. In the real world this leaves physicians to guess whether new findings can be extrapolated to the rest of their patients. For instance, no one knows if aspirin has any prophylactic value in coronary artery disease in women because virtually all the current evidence is from studies on men. And for most classes of drugs, no one knows if ethnic variations in drug metabolism exist, or where they have been seen, as with β-blockers and antidepressants, what the full extent of their clinical relevance might be. These gaps remain despite documentation of important differences in drug responses and risk profiles among women, the elderly, and
INTRACORONARY STEM CELL THERAPY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION &amp;ndash; 36 MONTHS RESULTS OF A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL WITH SERIAL MRI FOLLOW-UPS
Authors: Jochen Woehrle, Fabian von Scheidt, Sinisa Markovic, Peter Schauwecker, Klaus Schwarz, Markus Wiesneth, Hubert Schrezenmeier, Vinzenz Hombach, Wolfgang Rottbauer, Peter Bernhardt
Journal: Journal of the American College of Cardiology (2012)
UNUSUAL EFFECT OF HOMATROPIN.REPORT OF TWO CASES.
Authors: JOSEPH W. SHERER
Journal: JAMA (1906)

The following report of an extraordinary effect of a much used drug is instructive and of interest as illustrating the idiosyncrasy of individuals in their relation to medicines. In these cases the apparent physiologic action of homatropin hydrobromid was irregular to an extraordinary degree. The two observations here chronicled are the only instances which have come under my notice of excessive persistence of the effect.  I am unable to estimate a percentage of frequency for the occurrence of this accident, but suppose it to be rare, for these two cases are the only instances which have occurred in using homatropin several thousand times. The experience of others in this particular should be of interest to all. It is of moment to every practitioner, for the reason that it is especially in the more urgent cases of persons whose time is of great value that homatropin is employed.  I have just
The Accident Process
Authors: Alexander H. Hirschfeld
Journal: JAMA (1966)

Peptic ulcers and other suggestions of depression appear in histories of accident victims, indicating that disability exists before the mishap. After the accident has occurred, this disability is linked with an apparent physical defect, and it becomes acceptable to both patient and society. Breaking this linkage is an important factor in successful therapy. Of equal interest is the fact that prior depression has measurable physical components. Increases occur in adrenal and gastric secretions. Ketosteroid, metadrenalin, normetadrenal, thyroid, and estrogen titers change, some in blood, others in urine. Such physical variables of preaccident depression could be measured for prediction and possibly for preventive therapy.
Impaired Insulin Sensitivity as an Independent Risk Factor for Mortality in Patients With Stable Chronic Heart Failure
Authors: Wolfram Doehner, Mathias Rauchhaus, Piotr Ponikowski, Ian F. Godsland, Stephan von Haehling, Darlington O. Okonko, Francisco Leyva, Anthony J. Proudler, Andrew J.S. Coats, Stefan D. Anker
Journal: Journal of the American College of Cardiology (2005)
Identification of Biomarkers for PKD1 Using Urinary Exosomes
Authors: Marie C. Hogan, Jason L. Bakeberg, Vladimir G. Gainullin, Maria V. Irazabal, Amber J. Harmon, John C. Lieske, M. Cristine Charlesworth, Kenneth L. Johnson, Benjamin J. Madden, Roman M. Zenka, Daniel J. McCormick, Jamie L. Sundsbak, Christina M. Heyer, Vicente E. Torres, Peter C. Harris, Christopher J. Ward
Journal: Journal of the American Society of Nephrology (2014)

Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD. Affected individuals inherit a defective copy of either PKD1 or PKD2, which encode polycystin-1 (PC1) or polycystin-2 (PC2), respectively. PC1 and PC2 are secreted on urinary exosome-like vesicles (ELVs) (100-nm diameter vesicles), in which PC1 is present in a cleaved form and may be complexed with PC2. Here, label-free quantitative proteomic studies of urine ELVs in an initial discovery cohort (13 individuals with PKD1 mutations and 18 normal controls) revealed that of 2008 ELV proteins, 9 (0.32%) were expressed at significantly different levels in samples from individuals with PKD1 mutations compared to controls (P<0.03). In samples from individuals with PKD1 mutations, levels of PC1 and PC2 were reduced to 54% (P<0.02) and 53% (P<0.001), respectively. Transmembrane protein 2 (TMEM2), a protein with homology to fibrocystin, was 2.1-fold higher in individuals with PKD1 mutations (P<0.03). The PC1/TMEM2 ratio correlated inversely with height-adjusted total kidney volume in the discovery cohort, and the ratio of PC1/TMEM2 or PC2/TMEM2 could be used to distinguish individuals with PKD1 mutations from controls in a confirmation cohort. In summary, results of this study suggest that a test measuring the urine exosomal PC1/TMEM2 or PC2/TMEM2 ratio may have utility in diagnosis and monitoring of polycystic kidney disease. Future studies will focus on increasing sample size and confirming these studies. The data were deposited in the ProteomeXchange (identifier PXD001075).
Autoimmune Progesterone Dermatitis
Authors: Walter B Shelley, Robert W. Preucel, Stanley S. Spoont
Journal: JAMA (1964)

A chronic and extensive distinctive pruritic vesiculobullous eruption in a young woman resembled dermatitis herpetiformis clinically and erythema multiforme histologically. The most remarkable feature was the regular premenstrual exacerbation. Study revealed that flares could be excited by progesterone and progestational compounds. Within seven hours a single dose of progesterone induced pruritus, and a clinical flare associated with marked degranulation and later disappearance of the circulating basophil leukocytes. In turn, clinical remission could be induced by estinyl estradiol for oral administration in a dosage sufficient to suppress ovulation. Oophorectomy was followed by complete involution of all clinical signs and symptoms. The eruption is viewed as an autoimmune phenomenon triggered premenstrually by endogenous progesterone.
Muscle Blood Flow During Exercise in Intermittent Claudication
Authors: K. H. TØNNESEN
Journal: Circulation (1968)

Pathophysiological considerations predict that exercise blood flows at comparable work loads must always be reduced in claudicants in comparison to normal subjects. The present study verified that the exercise blood flow determined by 133 xenon clearance measurements in the gastrocnemius muscle in claudicants and in a control group differed widely. As expected, a statistically significant correlation was found between the first flow by plethysmography and the maximal exercise blood flow determined by the 133 xenon clearance technique in the patients and for the whole material (but not for the control group alone). The exercise blood flow determined by 133 xenon clearance in the claudicants was statistically significantly correlated to the walking distance, measured on a treadmill, while the postexercise blood flow as measured by plethysmography was not. This finding establishes the concept, that the 133 xenon clearance technique can be applied in quantitating the degree of arterial insufficiency.
Monitor Passes First Tests With Flying Colors
Authors: Andrew A. Skolnick
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer.
Authors: K Yamasaki, H D Edington, C McClosky, E Tzeng, A Lizonova, I Kovesdi, D L Steed, T R Billiar
Journal: Journal of Clinical Investigation (1998)

Most evidence indicates that nitric oxide plays a role in normal wound repair; however, involvement of inducible nitric oxide synthase (iNOS) has not been established. Experiments were carried out to determine the requirement for iNOS in closing excisional wounds. Wound closure was delayed by 31% in iNOS knockout mice compared with wild-type animals. An identical delay in wound closure was observed in wild-type mice given a continuous infusion of the partially selective iNOS inhibitor N6-(iminoethyl)-L-lysine. Delayed wound healing in iNOS-deficient mice was completely reversed by a single application of an adenoviral vector containing human iNOS cDNA (AdiNOS) at the time of wounding. Reverse transcription PCR identified iNOS mRNA expression in wild-type mice peaking 4-6 d after wounding, and confirmed expression of human iNOS in the adenoviral vector containing human iNOS cDNA-treated animals. These results establish the key role of iNOS in wound closure, and suggest a gene therapy strategy to improve wound healing in iNOS-deficient states such as diabetes, and during steroid treatment.
Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine
Authors: Raphael Itzykson, Sylvain Thépot, Bruno Quesnel, Francois Dreyfus, Odile Beyne-Rauzy, Pascal Turlure, Norbert Vey, Christian Recher, Caroline Dartigeas, Laurence Legros, Jacques Delaunay, Célia Salanoubat, Sorin Visanica, Aspasia Stamatoullas, Francoise Isnard, Anne Marfaing-Koka, Stephane de Botton, Youcef Chelghoum, Anne-Laure Taksin, Isabelle Plantier, Shanti Ame, Simone Boehrer, Claude Gardin, C. L. Beach, Lionel Adès, Pierre Fenaux
Journal: Blood (2010)