tbuckley/cabot-search huggingface dataset:
Prothèses oesophagiennes et maladies bénignes de l'oesophage: efficacité initiale, complications et résultats à long terme
Authors: A Oden-Gangloff, S Lecleire, M Antonietti, I Iwanicki-Caron, P Ducrotté
Journal: Endoscopy (2010)

Introduction: Les prothèses oesophagiennes n'ont été que peu évaluées dans les pathologies bénignes de l'oesophage. Le but de notre étude était d'évaluer l'efficacité et les complications des prothèses oesophagiennes dans cette indication, comprenant les sténoses bénignes quelle qu'en soit l'origine (radique, caustique, peptique, anastomotique ou après photothérapie dynamique) et les perforations ou fistules survenant sur une pathologie non tumorale de l'oesophage.
C-reactive protein activates the NF-κB signal transduction pathway in human saphenous vein endothelial cells
Authors: Subodh Verma, Mitesh V. Badiwala, Chao H. Wang, Richard D. Weisel, Shu-Hong Li, Dhillon Bikramjit, Paul W. Fedak, Ren-Ke Li, Donald A. Mickle
Journal: Journal of the American College of Cardiology (2003)
Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs
Authors: Andreas C. Hocke, Anne Becher, Jessica Knepper, Andrea Peter, Gudrun Holland, Mario Tönnies, Torsten T. Bauer, Paul Schneider, Jens Neudecker, Doreen Muth, Clemens M. Wendtner, Jens C. Rückert, Christian Drosten, Achim D. Gruber, Michael Laue, Norbert Suttorp, Stefan Hippenstiel, Thorsten Wolff
Journal: American Journal of Respiratory and Critical Care Medicine (2013)
Mongolia: a health system in transition.
Authors: S Manaseki
Journal: BMJ (1993)

70% of the 2.2 million population of Mongolia are younger than 35 years old. More than 75% of the population live in urban areas, but many adopt the traditional nomadic lifestyle for at least a few weeks each year. 95% of the population is literate. Winters produce extremely cold temperatures and shortages. Mongolia has a well structured and staffed health care system. 3.9 physicians serve 1000 people. Women comprise more than 80% of physicians. Leading causes of mortality and morbidity are acute respiratory infections (ARIs) in the winter and diarrhea in the summer, particularly among children. Hypertension and ischemic heart disease are common. Mongolians are the greatest consumers of red meat in Asia and perhaps the world. The health system is in the process of switching from a centralized system of specialist clinics to a family doctor system. Family doctors usually are general physicians, pediatricians, and gynecologists who have undergone family doctor training. They have not received adequate training in treating ARIs, however. Family doctor clinics have 3-6 physicians, each physician with his/her own nurse. Each physician cares for 200-350 families (350-600 children younger than 16). Family doctors must visit each newborn every 2 weeks for the first 3 months and then once a month until age 1. They must also visit each elderly and homebound chronically ill patient at least once a month. Their nurses either come with them or visit patients alone to administer injections, change dressings, take infants' measurements, and encourage persons to come for vaccinations. The small district and county hospitals face shortages of drugs, raw materials, and functional equipment. The few national hospitals provide tertiary care. Treatment without medicine and traditional treatments of herbal remedies and Buddhist rituals and prayers are resurging in popularity. Harmful practices include swaddling babies, which contributes to rickets and pneumonia, and giving ill children their mother's early morning urine. Immunization coverage is high. Supplementary ration cards provide milk, flour, meat, rice, and sugar to pregnant women and mothers of children under 1 year old. Milk centers in major towns provide milk to children with a doctor's prescription. Even though malnutrition is rare, vitamin deficiencies are common.
Extensive sharing of epitopes between group 1 allergens of cedar pollen
Authors: T. Midoro-Horiuti, V. Mathura, C.H. Schein, W. Braun, A. Togawa, T. Oka, M. Watanabe, E.G. Brooks, R.M. Goldblum
Journal: Journal of Allergy and Clinical Immunology (2003)
Human Immunodeficiency Virus (HIV) and Aplastic Anemia
Authors: J.M. Grau
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 April 1989Human Immunodeficiency Virus (HIV) and Aplastic AnemiaJ.M. Grau, MD, X. Bosch, MD, A.C. Salgado, MD, A. Urbano-Márquez, MDJ.M. Grau, MDSearch for more papers by this author, X. Bosch, MDSearch for more papers by this author, A.C. Salgado, MDSearch for more papers by this author, A. Urbano-Márquez, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-7-576 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Although numerous opportunistic infections have been reported in either patients with the acquired immunodeficiency syndrome (AIDS) or the AIDS-related complex (1), only a few cases of visceral leishmaniasis in these patients have been reported (2-4). We report a case of this disease in a patient with an atypical presentation that consisted of prolonged fever and progressive severe pancytopenia, but no spleen enlargement or hyperglobulinemia.A 35-year-old white man who reported only occasional intravenous drug abuse and heterosexual promiscuity (one of his sex partners was positive for human immunodeficiency virus [HIV] ) was hospitalized in May 1988 for...References1. GlattChirgwinLandesman AKS. Treatment of infections associated with human immunodeficiency virus. N Engl J Med. 1988;318:1439-48. CrossrefMedlineGoogle Scholar2. Fernández-GuerreroAguadoBuzón MJL. Visceral leishmaniasis in immunocompromised hosts. Am J Med. 1987;83:1098-102. CrossrefMedlineGoogle Scholar3. SenaldiCadeoCarnevaleDi PeniCarosi GGGGG. Visceral leishmaniasis as an opportunistic infection. Lancet. 1986;1:1094. Google Scholar4. Martínezde LetonaMata VázquezPérez LJCR. Visceral leishmaniasis as an opportunistic infection. Lancet. 1986;1:1094. Google Scholar5. CrocchioloLizioliLeopardi PAO. HIV and aplastic anaemia. Lancet. 1988;2:109. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital Clínico y Provincial Barcelona, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHypercellular bone marrow in aplastic anemia: A case report of two patientsAplastic anemia: Etiology, molecular pathogenesis, and emerging conceptsLeishmania SpeciesLeishmaniasisLeishmania SpeciesLeishmania and human immunodeficiency virus coinfection: the first 10 yearsLeishmaniose visceral fatal associada à síndrome de imunodeficiência adquirida: relato de caso com achados necroscópicos e estudo imuno-histoquímicoVisceral leishmaniasis in patients infected with human immunodeficiency virus 1 April 1989Volume 110, Issue 7Page: 576-577KeywordsAIDSAplastic anemiaDrug abuseFeversHIVHeterosexualsHyperglobulinemiaLeishmaniasisOpportunistic infectionsSpleen Issue Published: 1 April 1989 PDF DownloadLoading ...
Oral Combination Chemotherapy in the Management of AIDS-Related Lymphoproliferative Malignancies
Authors: Scot C. Remick, Nell Sedransk, Richard Haase, Mark Craffey, Neepa Subramanian, Afshin Dowlati, Tipu Nazeer, Carm Ramnes, Christina Blanchard, David Mastrianni, Lodovicco Balducci, John Horton, John C. Ruckdeschel
Journal: Drugs (1999)
1172 FUNCTIONAL ANALYSIS OF THE DIACYLGLYCEROL ACYLTRANSFERASE ACTIVITY-1 (DGAT1) IN THE REPLICATION OF HEPATITIS C VIRUS: EFFECT OF QUERCETIN
Authors: Á. Rojas, M. García-Valdecasas, J.A. del Campo, M. Romero-Gomez
Journal: Journal of Hepatology (2013)
Breast Cancer Detection With Tc-99m Tetrofosmin
Authors: PIER FRANCESCO RAMBALDI, LUIGI MANSI, EUGENIO PROCACCINI, FERNANDO DI GREGORIO, ENRICO DEL VECCHIO
Journal: Clinical Nuclear Medicine (1995)

Myocardial SPECT imaging was performed with Tc-99m tetrofosmin. Intense focal uptake at the level of the left breast was observed. At mammography a breast carcinoma was suspected, which was confirmed after surgery. This may be the first report of neoplastic mammary uptake of Tc-99m tetrofosmin.
Abstract IA23: Cervical tissue T cells in HPV disease.
Authors: C.L. Trimble, J. Teague, T.C. Wu, R.A. Clark
Journal: Cancer Research (2013)

Abstract Despite the availability of preventative vaccines, human papillomaviruses (HPVs) cause more cancers than any other virus. Like other viral pathogens that cause human cancers, most HPV infections do not cause overt harm, let alone symptoms. Indeed, in immune-competent persons, most genital infections are eventually cleared. Nonetheless, the incidence of HPV-associated cancers in anatomic sites for which no screening algorithms have been validated is rising steadily. Preinvasive, intraepithelial lesions are associated with integration of the HPV genome into the host genome, and subsequent expression of the viral oncoproteins, E6 and E7, which are required for disease initiation and persistence. These true tumor-specific antigens provide non-“self” targets for immune therapies. The relatively indolent clinical course of preinvasive lesions, and tissue tropism of HPV infections provide opportunities to identify and treat early stage disease. In cervical HPV disease, a subset of high grade dysplastic lesions, cervical intraepithelial neoplasia grade 3 (CIN3), do in fact undergo complete regression, which is presumably immunologically mediated. However, T cell responses to viral antigens, measured in the blood, have not been informative with respect to immune responses in the cervical mucosa. Our team has been studying strategies to enhance the quality and magnitude of immune responses to HPV antigens. Ongoing clinical trials testing therapeutic vaccination and strategies to manipulate the lesion microenvironment to enhance homing and access of immune effector cells will be discussed. The design of these trials has been informed by studies of tissue-resident T cells in normal cervical mucosa, and by changes identified in dysplastic mucosa, both in lesions that regress, and in those that do not, in the course of a defined, prospective study window. Changes in the composition and distribution of tissue T cells postvaccination will be presented. Strategies to modify the stromal compartment of HPV lesions to promote lesion clearance will also be discussed. Citation Format: C.L. Trimble, J. Teague, T.C. Wu, R.A. Clark. Cervical tissue T cells in HPV disease. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; Dec 2-5, 2012; Miami, FL. Philadelphia (PA): AACR; Cancer Res 2013;73(1 Suppl):Abstract nr IA23.
STUDIES ON THE TRANSFER OF LYMPH NODE CELLS
Authors: T. N. Harris, Susanna Harris, Miriam B. Farber
Journal: The Journal of Experimental Medicine (1956)

Leucocytes were obtained from the blood of rabbits, incubated in vitro with soluble antigenic material derived from Shigella paradysenteriae, washed, and transferred to irradiated recipient animals. On the 4th day after cell transfer, agglutinins to Shigella appeared in the sera of the majority of such recipients. The distribution of maximum agglutinin titers was substantially lower in these animals than in recipients of lymph node cells similarly incubated, as reported in earlier studies. Recipients of iodoacetate-treated cells showed no agglutinins. Similar results were obtained with cells of peritoneal exudates obtained 9 days after the intraperitoneal injection of lanolin and light mineral oil. When cells of peritoneal exudates obtained 1 or 2 days after the injection of this irritant were incubated with the antigenic material and transferred to irradiated recipients, agglutinins did not appear in the sera of the latter. Similar results were obtained with cells from peritoneal exudates obtained a few days after the intraperitoneal injection of heavy mineral oil. The preponderant cell types in the suspensions from these two sources were the polymorphonuclear neutrophils and monocytes, respectively.
Quality Assurance in Molecular Genetic Testing Laboratories
Authors: Margaret M. McGovern
Journal: JAMA (1999)

Context Specific regulation of laboratories performing molecular genetic tests may be needed to ensure standards and quality assurance (QA) and safeguard patient rights to informed consent and confidentiality.However, comprehensive analysis of current practices of such laboratories, important for assessing the need for regulation and its impact on access to testing, has not been conducted.Objective To collect and analyze data regarding availability of clinical molecular genetic testing, including personnel standards and laboratory practices.Design A mail survey in June 1997 of molecular genetic testing laboratory directors and assignment of a QA score based on responses to genetic testing process items.Setting Hospital-based, independent, and research-based molecular genetic testing laboratories in the United States.Participants Directors of molecular genetic testing laboratories (n = 245; response rate, 74.9%).Main Outcome Measure Laboratory process QA score, using the American College of Medical Genetics Laboratory Practice Committee standards. ResultsThe 245 responding laboratories reported availability of testing for 94 disorders.Personnel qualifications varied, although all directors had doctoral degrees.The mean QA score was 90% (range, 44%-100%) with 36 laboratories (15%) scoring lower than 70%.Higher scores were associated with test menu size of more than 4 tests (P = .01),performance of more than 30 analyses annually (P = .01),director having a PhD vs MD degree (P = .002),director board certification (P = .03),independent (P Ͻ.001) and hospital (P = .01)laboratories vs research laboratory, participation in proficiency testing (PϽ.001), and Clinical Laboratory Improvement Amendment certification (P = .006).Seventy percent of laboratories provided access to genetic counseling, 69% had a confidentiality policy, and 45% required informed consent prior to testing. ConclusionThe finding that a number of laboratories had QA scores that may reflect suboptimal laboratory practices suggests that both personnel qualification and laboratory practice standards are most in need of improvement to ensure quality in clinical molecular genetic testing laboratories.
A CASE OF POISONING BY METALLIC NICKEL.
Authors: GEORGE RICHTER
Journal: JAMA (1907)

It is well known that a number of metals like zinc, lead, etc., when inhaled or swallowed with atmospheric dust may produce symptoms of poisoning, but of poisoning by metallic nickel I have found no record. The case I report was not observed so closely as might be desired, yet a number of facts have been recorded which may be of interest. <h3>History.</h3> —C. S., male, aged 24, of slender build, weighed 116 pounds (never over 119 pounds), height 5 feet 7 inches. Worked as a metal polisher, polishing aluminum, copper, brass, and mostly nickel. The process generates considerable dust, which is only partially removed by "sucking blowers" instituted for the protection of the workers. Gave a history of diphtheria and typhoid fever in childhood, otherwise healthy. Inclined to be constipated. Denied syphilis and other contagious diseases. In his work the patient was of cleanly habits, always washing his hands
AN UNUSUAL CASE OF BLOOD CYST OF THE POSTERIOR NARES.
Authors: JOHN N. MACKENZIE
Journal: JAMA (1898)

DISCUSSION.Dr. Solly-I once found a calculus in the submaxillary gland.I have never seen a case reported where the calculus was imbedded in the body of the gland.An incision was made following up the duct and the stone was felt by the finger, im- bedded in the gland, and was then forced into the mouth and removed.The stone was about the size of a chestnut and weighed twenty-five ór thirty grains.Dr. Freddenthal-I am sure that there are several cases on record where the stone was in the body of the gland.Dr. Bull of New York has one, and there is a case reported by another surgeon whose name I do not recall, in which the stone could not be reached from the inside of the mouth and he had to make an incision from the outside.
The effect of jejunoileal bypass on the pharmacokinetics of digoxin in man.
Authors: F I Marcus, E J Quinn, H Horton, S Jacobs, S Pippin, M Stafford, C Zukoski
Journal: Circulation (1977)

Seven subjects who underwent jejunoileal bypass surgery for massive obesity participated in a study to examine the relative bioavailability of digoxin before and one to two months after surgery. They were given a loading dose of 1 mg digoxin in divided oral doses followed by oral maintenance doses of 0.5 mg daily. There were no significant differences in the area under the serum concentration time curve, steady state serum levels or 24 hour steady state excretion of digoxin before and after surgery. We conclude that the bioavailability of digoxin from the Lanoxin tablets employed is not impaired in these patients, although urinary d-xylose and 24 hour fecal fat excretion indicated moderate to severe malabsorption after surgery.
Presence of gas in the refluxate enhances reflux perception in non-erosive patients with physiological acid exposure of the oesophagus
Authors: S Emerenziani, D Sifrim, F I Habib, M Ribolsi, M P L Guarino, M Rizzi, R Caviglia, T Petitti, M Cicala
Journal: Gut (2007)

The mechanisms underlying symptoms in gastro-oesophageal reflux disease, particularly in non-erosive reflux disease (NERD), remain to be fully elucidated. Weakly acidic reflux and the presence of gas in the refluxate could be relevant in the pathogenesis of symptoms.To assess the relationship between symptoms and weakly acidic, acid and mixed (liquid-gas) reflux, 24 h oesophageal pH-impedance monitoring was performed in 32 NERD and in 20 oesophagitis patients. In 12 NERD patients the study was repeated following 4 weeks treatment with a proton pump inhibitor (PPI). Impedance-pH data were compared with those of 10 asymptomatic controls. Heartburn and acid regurgitation were considered in the analysis of symptoms.15 NERD patients showed a physiological acid exposure time (pH-negative). Weakly acidic reflux was significantly less frequent in patients (25% (2%), mean (SE)) than in controls (54% (4%), p<0.01). Gas was present in 45-55% of reflux events in patient groups and controls, and decreased following PPI treatment. In NERD pH-negative patients, weakly acidic reflux accounted for 32% (10%) (vs 22% (6%) in NERD pH-positive and 12% (8%) in oesophagitis patients) and mixed reflux for more than two-thirds of all symptom-related refluxes. Multivariate logistic analysis showed that in NERD pH-negative patients, the risk of reflux perception was significantly higher when gas was present in the refluxate (odds ratio, 3.2; 95% CI, 1.2 to 10; p<0.01).The large majority of symptoms, in all patients, are related to acid reflux. In NERD patients, the presence of gas in the refluxate significantly enhances the probability of reflux perception. These patients are also more sensitive to less acidic reflux than oesophagitis patients.
The TEC as a theory of embodied cognition
Authors: Daniel C. Richardson, Michael J. Spivey
Journal: Behavioral and Brain Sciences (2001)

We argue that the strengths of the Theory of Event Coding (TEC) can usefully be applied to a wider scope of cognitive tasks, and tested by more diverse methodologies. When allied with a theory of conceptual representation such as Barsalou's (1999a) perceptual symbol systems, and extended to data from eye-movement studies, the TEC has the potential to address the larger goals of an embodied view of cognition.
Fluid Retention Produced by Guanethidine
Authors: A. J. SMITH
Journal: Circulation (1965)

Total exchangeable sodium and blood volume increased during the first year's treatment of seven hypertensive patients with guanethidine. Creatinine clearance values fell over the same period. A similar change was seen in two patients receiving reserpine. It is suggested that the hemodynamic changes produced by hypotensive drugs are insufficient completely to explain the observations. A direct effect of guanethidine on sodium reabsorption in the kidney may also be involved.
CKD-EPI eGFR categories were better than MDRD categories for predicting mortality in a range of populations
Authors: Chi-yuan Hsu
Journal: Annals of Internal Medicine (2012)

Source Citation Matsushita K, Mahmoodi BK, Woodward M, et al; Chronic Kidney Disease Prognosis Consortium. Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate. JAMA. 2012;307:1941-51. 22570462
Too Smart for Primary Care?
Authors: Eric J. Warm, Celine Goetz
Journal: Annals of Internal Medicine (2013)

In the Balance19 November 2013Too Smart for Primary Care?Eric J. Warm, MD and Celine Goetz, MDEric J. Warm, MDFrom the University of Cincinnati, Cincinnati, Ohio, and New York-Presbyterian Hospital, New York, New York. and Celine Goetz, MDFrom the University of Cincinnati, Cincinnati, Ohio, and New York-Presbyterian Hospital, New York, New York.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-10-201311190-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail During a medical education conference, a prominent specialist asserted that students should not aspire to practice primary care because it does not demand excellence of its trainees. As a primary care physician and a fourth-year medical student, we were shocked by this statement. Together, we approached the speaker after his session to challenge his assertions. He stood firm.As a medical student at the time, one of us had personally experienced faculty members saying that she was too smart for primary care. Being told you are too smart for anything can be flattering. However, as someone who went to medical ... Author, Article, and Disclosure InformationAffiliations: From the University of Cincinnati, Cincinnati, Ohio, and New York-Presbyterian Hospital, New York, New York.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-0801.Corresponding Author: Eric J. Warm, MD, University of Cincinnati, 231 Albert Sabin Way, Mail Location 0557, Cincinnati, OH 45267-0557; e-mail, [email protected]uc.edu.Current Author Addresses: Dr. Warm: University of Cincinnati, 231 Albert Sabin Way, Mail Location 0557, Cincinnati, OH 45267-0557.Dr. Goetz: Department of Internal Medicine, New York-Presbyterian Hospital, 525 East 68th Street, New York, NY 10021.Author Contributions: Conception and design: E.J. Warm, C. Goetz.Drafting of the article: E.J. Warm, C. Goetz.Critical revision of the article for important intellectual content: E.J. Warm, C. Goetz.Final approval of the article: E.J. Warm, C. Goetz. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoToo Lazy for Primary Care? William G. Kussmaul III Too Smart for Primary Care Ian Jenkins Too Smart for Primary Care Caroline Poplin Too Smart for Primary Care Caroline Poplin Too Smart for Primary Care Ian Jenkins Metrics Cited ByOsteopathic Medical Education: Answering the CallCystic Fibrosis: Recent Successes Present New ChallengesJoseph M. Pilewski, MD and Darren B. Taichman, MD, PhD, Executive Deputy EditorToo Smart for Primary CareIan Jenkins, MDToo Smart for Primary CareCaroline Poplin, MD, JD 19 November 2013Volume 159, Issue 10Page: 709-710KeywordsAcademic medicineHealth careHospital medicineMedicarePrimary careRashesStandardized testsStent implantationSub-specialty care ePublished: 19 November 2013 Issue Published: 19 November 2013 CopyrightCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...