tbuckley/cabot-search huggingface dataset:
Everyone Here Spoke Sign Language: Hereditary Deafness on Martha's Vineyard
Authors: R. Gregg Emerton
Journal: JAMA (1986)

The title of this book bespeaks the major themes of the author. It is, to begin with, a scholarly investigation of an unusually large incidence of hereditary deafness that occurred on the island of Martha's Vineyard from its colonial settlement until the early 20th century. The true importance of this book, however, is implied in the phrase "Everyone here spoke sign language," for Groce has provided us with a verified example of the fact that deafness need not necessarily be socially isolating and that deaf people can be socially integrated into the larger community. In her investigation of deafness on the island, Groce used an ethnohistoric approach. This included interviews with some 200 islanders to record the oral history of the community and an exhaustive search of written records to try to confirm these accounts. Groce was able, for example, to track down the "missing" and largely unpublished research notes
Cellular mechanisms of normal growth in the mammalian heart. I. Qualitative and quantitative features of ventricular architecture in the dog from birth to five months of age.
Authors: M J Legato
Journal: Circulation Research (1979)

This paper describes the qualitative and quantitative composition of dog myocardium over the first 5 months of life. The quantitative composition of dog right and left ventricle over this period does not vary. A stereological analysis of electron micrographs representing 32,000 micron2 of tissue surface revealed that 79% of the heart is made up of myofibers, whereas 21% is extracellular space. Twenty-eight percent of the extracellular compartment by volume is vasculature (tissue was preserved by immersion rather than vascular perfusion); 72% is occupied by nonvascular elements and "empty" space. In contrast to the remarkable constancy of quantitative composition of the whole myocardium, myocyte shape and dimensions and the arrangement of intercellular connections vary dramatically over the age period studied. In early postnatal life, the morphology of blood vessels, many of which have completely partitioned lumina, also changes significantly.
TCT-108 Baseline Mitral Regurgitation Does Not Affect 30 Day to Two Year Mortality after Transcatheter Aortic-Valve Implantation (TAVI). A Report on 576 Patients from the Swedish TAVI Registry.
Authors: Andreas Rück, Magnus Settergren, Keita Yamasaki
Journal: Journal of the American College of Cardiology (2013)
Clinical Trial of Acepromazine Maleate in Chronic Schizophrenia
Authors: J. F. Collard, R. Maggs
Journal: BMJ (1958)

Five cases of operative removal of splenic aneurysms are reported.In this series there was one death follow- ing rupture of an aneurysm, and one recovery after rupture of an aneurysm in a pregnant woman; another patient had a porto-caval shunt.In the three patients with unruptured aneurysms the diagnosis was made by the radiologist before operation, and these patients survived.I am indebted to Dr.
ATTACKS OF SYNCOPE, VERTIGO AND APHONIA OF UNCERTAIN ORIGIN, POSSIBLY DUE TO LIGHTNING STROKE.
Authors: J. A. PALMER
Journal: JAMA (1907)

The following case presents a syndrome, apparently either of intracranial or intrathoracic origin, the genesis of which seems very difficult to explain. <h3>History.</h3> —A. A., aged 54, married, a carpenter and farmer, was born in America. The family history was negative. He had had no severe illness in childhood, although never considered exactly strong, and he says that as a boy everything seemed to go to his head. He had no injury in early life and his habits had been good. At the age of 31 he had an attack of acute inflammatory rheumatism from which he recovered. Fifteen years ago he was shocked by a stroke of lightning, but after a few minutes recovered so that he was able to ride one of his horses to the barn, although for twenty-four hours he was dazed or partially stupefied. About a year after this the first symptoms of the present
Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: a preliminary investigation.
Authors: D G Godfrey, W H Stimson, J Watson, J F Belch, R D Sturrock
Journal: Annals of the Rheumatic Diseases (1986)

The effects of dietary fatty acid supplementation on various disease parameters in the spontaneously autoimmune MRL-mp-lpr/lpr mouse model of systemic lupus erythematosus before onset of disease were investigated. A fat deficient diet was supplemented with the following oils: olive oil, sunflower oil, evening primrose oil (EPO), fish oil, and a fish oil/EPO mixture. The mice receiving a diet enriched with EPO showed an increase in survival, as did those receiving the fish oil/EPO mixture. These results, taken together with those of the other parameters monitored, suggest that EPO may be of benefit in alleviating the murine form of the disease.
Activation of Ion Channels in Tumor Cells by Leukoregulin, a Cytostatic Lymphokin
Authors: P. A. Sheehy, S. C. Barnett, C. H. Evans, J. L. Barker
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Activation of Ion Channels in Tumor Cells by Leukoregulin, a Cytostatic Lymphokin Get access P. A. Sheehy, P. A. Sheehy * 2Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and StrokeBethesda, MD *correspondence to: Dr. P. k Sheehy, Buildhg 36, Room 2C02, National Institutes of Health, Bethesda, MD 20892. Search for other works by this author on: Oxford Academic PubMed Google Scholar S. C. Barnett, S. C. Barnett 3Laboratory of Biology, National Cancer InstituteBethesda Search for other works by this author on: Oxford Academic PubMed Google Scholar C. H. Evans, C. H. Evans 3Laboratory of Biology, National Cancer InstituteBethesda Search for other works by this author on: Oxford Academic PubMed Google Scholar J. L. Barker J. L. Barker 2Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and StrokeBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 11, 3 August 1988, Pages 868–871, https://doi.org/10.1093/jnci/80.11.868 Published: 03 August 1988 Article history Received: 25 January 1988 Revision received: 16 February 1988 Accepted: 06 May 1988 Published: 03 August 1988
Implementation of an evidence-based feeding guideline did not reduce mortality in intensive care units
Authors: Mauricio Ferri, Neill Adhikari
Journal: Annals of Internal Medicine (2009)

Source Citation Doig GS, Simpson F, Finfer S, et al. Effect of evidence-based feeding guidelines on mortality of critically ill adults: a cluster randomized controlled trial. JAMA. 2008;300:2731-41. 19088351
Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene.
Authors: L Franksson, E George, S Powis, G Butcher, J Howard, K Kärre
Journal: The Journal of Experimental Medicine (1993)

Presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules requires MHC-encoded molecules of the adenosine triphosphate binding cassette (ABC) family. Defects in these proteins represent a potential risk, since they are essential links in the machinery of T cell-mediated surveillance which continuously scrutinizes peptide samples of cellular proteins. Nevertheless, transfection of the mouse lymphoma mutant RMA-S with the rat ABC gene mtp2a (homologue to mouse HAM2 and human RING11), commonly termed TAP-2 genes, led to a marked increase in tumor outgrowth potential in vivo. This occurred despite restored antigen presentation and sensitivity to cytotoxic T lymphocytes, and was found to be due to escape from natural killer (NK) cell-mediated rejection. It has previously been proposed that adequate expression of self-MHC class I is one important mechanism to avoid elimination by NK cells. Our data argue that a defect in the machinery responsible for processing and loading of peptides into MHC class I molecules is sufficient to render cells sensitive to elimination by NK cells. The latter thus appear to function as a surveillance of the peptide surveillance machinery.
Misuse of Medical Profession
Authors: A. S. Gardiner
Journal: BMJ (1970)

Ban= 119 chore unlikely to be undertaken readily by general practitioners.Again, if it were undertaken, the number of specimens would be such as to swamp all available laboratory facilities (possibly something like 17,000 specimens would need to be obtained, trans- mitted, and examined in the laboratory each day throughout the United Kingdom).The introduction of convenient media for semiquantitative bacterial counts could help to cut this volume of work by about one third if the new technique allowed for incubation and reading on the practice premises; the Positives and doubtful positives only would be transmitted to the laboratory.There is nothing mystical about the technique, and personal experience supports the contention that it is well within the capability of a practice sister or other suitably trained worker.Three requirements must be met for this change in primary medical care to come about:Equipment: the commercially available media and a simple incubator would need to be readily available to all general practi- tioners who wish to use this method.Organization: including the establishing of van collection services, and better communi- cations with laboratories.Demonstration: that this method in fact raises the quality of medical care.-Iam, etc.,
Intra-mesenteric artery steroid administration relieved severe refractory gastro-intestinal graft-vs.-host disease in an allogeneic bone marrow transplantation patient
Authors: Tsutomu Sato, Sumio Sakamaki, Yasuhiro Nagaoka, Kageaki Kuribayashi, Yasuhiro Nagamachi, Kazuhiro Morii, Hisato Honma, Katsuhisa Kogawa, Junji Kato, Yoshiro Niitsu
Journal: American Journal of Hematology (1997)

We report a case of severe gastro-intestinal (G-I) graft-vs.-host disease (GVHD) successfully treated with intra-mesenteric artery steroid administration. A 29-year-old man with severe aplastic anemia (SAA) was submitted to HLA-identical unrelated allogeneic bone marrow transplantation (BMT) and was found to be suffering from grade IV G-I GVHD. Although cyclosporine, steroid pulse therapy, and FK506 proved ineffective, 30 mg of water-soluble prednisolone as administered into each the superior and inferior mesenteric artery with remarkable effects. This treatment was repeated two times, and the symptoms of G-I GVHD disappeared completely. Am. J. Hematol. 56:277–280, 1997. © 1997 Wiley-Liss, Inc.
Treatment of Gonococcal Osteomyelitis
Authors: John R. Black, Myron S. Cohen
Journal: JAMA (1984)

To the Editor.—  We refer to the article by Drs Tindall and Regan-Smith 1 on gonococcal osteomyelitis. We have recently reported an additional case 2 and reviewed three other cases not described in their article. Although gonococci that produce disseminated infections are usually exquisitely sensitive to penicillin, two of these additional cases of gonococcal osteomyelitis were caused by β-lactamase-producing strains. 3,4 This observation calls attention to two points: (1) The setting of acute, asymmetric pauciarticular arthritis in a sexually active patient is complex. While the response of patients with gonococcal arthritis to penicillin is usually dramatic, failure to respond may not absolutely exclude the diagnosis. (2) Empiric therapy with cefoxitin or cefotaxime 5 may be indicated for patients with presumed gonococcal arthritis or osteomyelitis who do not respond rapidly to penicillin and who may have had sexual exposure in areas where β-lactamase-producing gonococci have been isolated.
For and against Eusol.
Authors: J. L. Burton
Journal: BMJ (1992)

of dose in Procrustean NHS methadone pro- grammes.We believe that the time is right to form a multidisciplinary group to promote the rational, humane, and research validated maintenance treatment for opiate addicts that has been a valu- able and traditional feature of British practice since the Rolleston committee first recommended it in 1926.We invite interested doctors to join us in setting up a British Methadone Maintenance Forum and we hope to establish an annual confer- ence on methadone.
The Interface of Law and the Behavioral Sciences
Authors: David L. Bazelon
Journal: New England Journal of Medicine (1964)

THE recurrent problem at the interface of law and the behavioral sciences, the one we rarely get beyond in the courtroom, can be put this way: which of us, lawyer or psychiatrist, has primary responsibility for determining the issue of responsibility? Who is responsible for responsibility? I call this the "football question" — we make a football of the question of criminal responsibility, and kick it back and forth between our professions, and neither side makes much "yardage." The medical witness says to the lawyer, "What do you mean, 'responsible'; what does the Durham vs. United States decision mean when . . .
Research governance: regulating risk and reducing harm?
Authors: Sara Shaw, Geraldine Barrett
Journal: Journal of the Royal Society of Medicine (2005)

Risk assessment can be thought of as the lens through which we anticipate the consequences of research and the impact of the actions of researchers. The way in which risk of harm is managed in research is strongly influenced by the surrounding social and political environment, leading to differences in national and local styles of regulation and review. Different research studies carry different risks, so systems for review and approval must adapt to the question being asked and the nature of the study. Researchers can never wholly guarantee safety in any research but participants and researchers must be offered reasonable protection within any study, with appropriate arrangements in place should something go wrong.
Orthographic processing is universal; it's what you do with it that's different
Authors: Dennis Norris, Sachiko Kinoshita
Journal: Behavioral and Brain Sciences (2012)

Abstract We agree with Frost that the variety of orthographies in the world's languages complicates the task of “cracking the orthographic code.” Frost suggests that orthographic processing must therefore differ between orthographies. We suggest that the same basic orthographic processes are applied to all languages. Where languages differ is in what the reader must do with the results of orthographic processing.
Adrenal Haemangioblastoma Presenting as Phaeochromocytoma: A Rare Manifestation of Extraneural Hemangioblastoma
Authors: Prabal Deb, Seerat Pal, Vibha Dutta, Anand Srivastava, Akshay Bhargava, Krishan Kumar Yadav
Journal: Endocrine Pathology (2012)
The Potent and Selective CRTH2 Antagonist OC000459 Is Effective In The Treatment Of Eosinophilic Asthma When Given Once Daily
Authors: Roy Pettipher, Michael Perkins, Lisa Pearce Collins, Mark Baillet, Trevor Lewis, Jan Steiner, John Bell, Mark Payton, Michael Hunter
Journal: Journal of Allergy and Clinical Immunology (2014)
Serum Glutamic Oxalacetic Transaminase
Authors: Leon D. Sabath, Deborah A. Gerstein, Maxwell Finland
Journal: New England Journal of Medicine (1968)

Transient and sometimes marked elevations of serum glutamic oxalacetic transaminase were found in each of seven young adult male volunteers by a standard colorimetric assay after oral administration of one or two courses of 4 gm of erythromycin estolate. These elevations were shown to be due not to the enzyme but to an unidentified, trypsin-stable substance related to the administration of the antibiotic.
Applying World Wide Web Technology to the Study of Patients with Rare Diseases
Authors: Piet C. de Groen
Journal: Annals of Internal Medicine (1998)

Randomized, controlled trials of sporadic diseases are rarely conducted. Recent developments in communication technology, particularly the World Wide Web, allow efficient dissemination and exchange of information. However, software for the identification of patients with a rare disease and subsequent data entry and analysis in a secure Web database are currently not available. To study cholangiocarcinoma, a rare cancer of the bile ducts, we developed a computerized disease tracing system coupled with a database accessible on the Web. The tracing system scans computerized information systems on a daily basis and forwards demographic information on patients with bile duct abnormalities to an electronic mailbox. If informed consent is given, the patient's demographic and preexisting medical information available in medical database servers are electronically forwarded to a UNIX research database. Information from further patient-physician interactions and procedures is also entered into this database. The database is equipped with a Web user interface that allows data entry from various platforms (PC-compatible, Macintosh, and UNIX workstations) anywhere inside or outside our institution. To ensure patient confidentiality and data security, the database includes all security measures required for electronic medical records. The combination of a Web-based disease tracing system and a database has broad applications, particularly for the integration of clinical research within clinical practice and for the coordination of multicenter trials.
Thyroid Aspiration Cytology: Current Status
Authors: L. J. Layfield, E. S. Cibas, H. Gharib, S. J. Mandel
Journal: CA A Cancer Journal for Clinicians (2009)

In the adult population, thyroid nodules are common and are increasingly detected by ultrasound examination or other scanning techniques. Depending on their size and ultrasonographic features, these nodules may require further investigation, including tissue diagnosis. Fine-needle aspiration (FNA) has become the predominant method to obtain tissue for microscopic analysis. In October 2007, the National Cancer Institute sponsored a conference to review the state of the science for the use of FNA in the management of thyroid nodules. This conference reviewed indications for thyroid FNA and pre-FNA requirements, training and credentialing, techniques for thyroid FNA, diagnostic terminology and morphologic criteria, utilization of ancillary studies, and post-FNA testing and treatment options. The results of those discussions have been published in both print and electronic versions. The aim of the current article was to discuss indications for FNA, diagnostic terminology, and post-FNA options, issues that are important to physicians who are managing patients with thyroid nodules.
Implantable cardioverter defibrillators after acute myocardial infarction
Authors: R. Liew
Journal: BMJ (2010)

Evidence suggests no overall survival benefit if inserted within 40 days

Despite major advances during the past two decades in the management of patients with acute myocardial infarction, sudden cardiac death remains an important contributor to overall mortality.1 Several randomised controlled trials have established the effectiveness of implantable cardioverter defibrillators in reducing overall mortality in patients with a history of myocardial infarction and reduced left ventricular ejection fraction.2 Although the risk of sudden cardiac death is greatest in the first 30 days after acute myocardial infarction, especially in patients with left ventricular dysfunction or heart failure,3 two trials found that the insertion of an implantable cardioverter defibrillator at this early stage did not reduce all cause mortality.4 5 A possible reason is an increase in non-arrhythmic death in the early post-infarct period. The findings of many of the early trials of implantable cardioverter defibrillators are reflected in current national and international guidelines, which recommend that these devices should be considered in patients with a previous myocardial infarction (after at least 40 days) and left ventricular ejection fraction below 30-35%⇓.6 7



A recent study has shed further …
STYLET FOR URETERAL CATHETERS AND PLUGS FOR URETHRAL CATHETERS
Authors: Gideon Timberlake
Journal: JAMA (1933)

<h3>To the Editor:</h3> —For over twenty years, during which time I have watched catheters buckle for others and heard the operators begging for specially made stylets, I have gone on quietly with my own unpatented secret. I advise employment of steel guitar strings, unwrapped, and known as the second treble string, or B. They cost 15 cents. They may be cut off at the proper length. Care in cleansing, drying and oiling will keep them for months. This will serve as a wonderful splint to male ureteral catheters and greatly facilitate their introduction. I recommend as a catheter plug a golf tee of one-half inch top graduated down for one and five-eighths inches. The tees can be boiled, are obtainable in almost any color—though red seems appropriate—and will plug Pezzer catheters to number 36 French down to the smallest one any transurethral resectionist may desire to insert. The depression price
TCT-286 Treatment Of Coronary In-Stent Restenosis With Paclitaxel-Coated Balloon Catheter: 36- Month Clinical Results
Authors: Javier Benezet, Santiago Camacho-Freire, Alejandro Gutierrez-Barrios, Antonio Agarrado, Jesus Oneto
Journal: Journal of the American College of Cardiology (2014)
How can health service users contribute to the NHS research and development programme?
Authors: S. R Oliver
Journal: BMJ (1995)

The National Childbirth Trust, along with other groups of health service users, is working with health professionals and researchers in planning clinical trials, setting priorities for research, systematically reviewing research reports, and getting research findings into practice. User groups may bridge the gap between the public and researchers by explaining research issues to a wide audience, presenting the needs and views of health service users to the research community, and suggesting how members of the public may be approached for their views directly. Service users recognise their need for training and support, and they call for development and evaluation of this work.
Domiciliary night nursing service: luxury or necessity?
Authors: M H Martin, M Ishino
Journal: BMJ (1981)

The nursing records of the 242 patients who used the domiciliary night nursing care service in Newham Health District showed that three distinct groups of patients were nursed during 1979 at a cost of 8.8 pounds a day. Forty-three elderly chronically sick and five disabled patients aged under 50 received care for more than 28 days, 63 patients had terminal cancer, and 131 needed short-term care or observation. Data were also collected from a one-day survey of patients receiving care. This domiciliary care enabled the chronically sick and disabled to retain their independence and remain at home. Referrals from casualty departments and general practitioners avoided admission to acute beds. On account of the lack of continual surveillance the service is unsuitable for the elderly mentally ill.
THE JAPANESE EARTHQUAKE: Notes from Kobe on the Medical History
Authors: F. Barker, G. A. Bird
Journal: BMJ (1924)

Tetraform.CARBON TRTMACHLORIDB has become recognized as a useful drug in the treatment of hookworm and other diseases caused by intestinal parasites.It Is well known that commercial processes of manufacture lead to the occurrence of impurities.The dose given is relatively a large one, amounting in full to 60 minims.Some of the impurities which may be present as a result of tlje process of manufacture are toxic, notably carbon disulphide.
Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses
Authors: Rupali Das, Richard Komorowski, Martin J. Hessner, Hariharan Subramanian, Claudia S. Huettner, Daniel Cua, William R. Drobyski
Journal: Blood (2010)