tbuckley/cabot-search huggingface dataset:
(10) Alagille's syndrome (arteriohepatic dysplasia)
Authors: D.M. Lister, D. Shuttleworth, R.A.C. Graham-Brown, S. Tanner
Journal: British Journal of Dermatology (1986)

Journal Article (10) Alagille's syndrome (arteriohepatic dysplasia) Get access D.M. Lister, Drs, D.M. Lister, Drs Leicester Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar D. Shuttleworth, D. Shuttleworth Leicester Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar R.A.C. Graham‐Brown, R.A.C. Graham‐Brown Leicester Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar S. Tanner S. Tanner Leicester Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s30, 1 July 1986, Page 52, https://doi.org/10.1111/j.1365-2133.1986.tb07705.x Published: 01 July 1986
Epidemiological study of farmer's lung in five districts of the French Doubs province.
Authors: A Depierre, J C Dalphin, D Pernet, A Dubiez, C Faucompre, J L Breton
Journal: Thorax (1988)

The prevalence of farmer9s lung was studied in five districts of the French Doubs province (Rougemont, Clerval, Levier, Montbenoît, Mouthe) on the basis of a medical and occupational questionnaire and serological studies for precipitins. Of the 1763 active farmers (response rate 69%) who participated in the study, 270 were suspected of having farmer9s lung and divided, on the basis of clinical and serological criteria, into probable and possible farmer9s lung groups. This subgroup of 270 patients was examined in more detail with physical examination, chest radiographs, and pulmonary function tests. Probable farmer9s lung was diagnosed in 77 cases (53 men and 24 women, mean age 51.7 years), a prevalence of 43.7/1000. Possible farmer9s lung was present in a further 193 subjects. Fever was the most specific symptom. In the group with probable farmer9s lung the frequency of crepitations, restrictive ventilatory defect, and radiological interstitial abnormalities was 21.5%, 9.5%, and 9.2% at the time of the study. Farmer9s lung was more common in the middle tablelands than in the plain or mountain areas (p less than 0.01). The difference in prevalence of farmer9s lung between the Mouthe mountain and Levier middle tableland districts (25.2/1000 and 60.8/1000) raises the possibility that cold may protect against the disease. Farmer9s lung was more frequent in men and in the age group 51-55 years. Among possible occupational factors, only regular work connected with feeding animals was associated with a significant risk (odds ratio 2.55 with a 95% confidence interval of 1.09-5.93). The frequency of chronic bronchitis in the population studied was 14.8%. There was a close link between farmer9s lung and chronic bronchitis, 50.6% of patients with probable farmer9s lung having it but only 8.6% of patients without farmer9s lung (p less than 0.001). In patients with probable farmer9s lung chronic bronchitis was independent of smoking and age. There were fewer smokers in the probable farmer9s lung than in the non-farmer9s lung group (p less than 0.05).
Lupus-like Syndrome Induced by Penicillamine In Cystinuria
Authors: I. Oliver
Journal: JAMA (1972)

To the Editor.—  Among the variety of toxic reactions caused by penicillamine, a lupus-like syndrome has been recently reported in a patient with Wilson's disease 1 treated with this drug. In view of the apparent rarity of this reaction to penicillamine, we wish to add a report on a patient with cystine lithiasis in whom a lupus-like syndrome was induced by this treatment.  Report of a Case.—  A 47-year-old woman with cystinuria, known to suffer from cystine stones since 1944, was admitted in June 1969 for treatment with penicillamine. In 1955 she underwent right nephrectomy because of a large cystine stone and pyonephrosis. In 1967 and in 1969 emergency ureterolithotomies were performed because of ureteral obstruction by cystine calculi, occurring in spite of treatment by forced fluid intake and alkalinization. On admission the urine contained a few red blood cells and numerous cystine crystals, but there was no proteinuria. Results
Kidney histopathological findings in fatal pandemic 2009 influenza A (H1N1)
Authors: Nicolás Nin, José A. Lorente, Carolina Sánchez-Rodríguez, Rosario Granados, Lorena S. Ver, Luis Soto, Jefferson Hidalgo, Pilar Fernández-Segoviano, Juan Ortín, Andrés Esteban
Journal: Intensive Care Medicine (2011)
Anatomical and developmental patterns of facilitative glucose transporter gene expression in the rat kidney.
Authors: E Chin, J Zhou, C Bondy
Journal: Journal of Clinical Investigation (1993)

In situ hybridization was used to map cellular patterns of gene expression for facilitative glucose transporters (GTs) 1-5 in the developing and adult rat kidney. GT3 was not detected. GT1 mRNA was present in the proximal straight tubule (PST), distal nephron and collecting duct. GT2 mRNA was localized in both proximal convoluted and PST, while GT5 mRNA was detected only in the PST. GT4 mRNA and immunoreactivity were focally localized in the thick ascending limb of Henle's loop and were coexpressed with IGF-I. Thus, each of the four different isoforms demonstrated a distinct renal distribution, with GTs 1, 2, and 5 coexpressed in the PST. Renal GT1 and GT5 gene expression were unchanged throughout development, while GT2 was most abundant before weaning and GT4 was first detected after weaning. Only GT4 appeared to be hormonally regulated: It was decreased after hypophysectomy and increased after vasopressin treatment, but was not affected by 1 or 4 d of insulinopenic diabetes mellitus. The coexpression of GT4 and IGF-I in the thick ascending limb segment of the nephron suggests a novel autocrine/paracrine mechanism by which cells may control local fuel economy independently from that of the larger structure to which they belong and from the systemic hormonal milieu.
Epilepsy and driving
Authors: S. Shorvon
Journal: BMJ (1995)

Many countries restrict the issue of driving licences to people prone to epileptic seizures. Regulations are deemed necessary because research has repeatedly shown an increased rate of road traffic accidents (and accidental deaths) in drivers with epilepsy.1 2 3 4 5 6 7 8

Ideally legislation should balance the excess risks of driving against the social and psychological disadvantage to people of prohibiting driving, but achieving this balance is difficult, and regulations vary widely among countries.8 In Britain the lifelong prohibition against driving enacted in the 1920s was changed in 1969 to permit those who had been free of seizures for at least three years to drive. In 1982 the seizure free period was reduced to two years (but remained at three years for people whose attacks occurred only during sleep). The law was later changed again, in January 1993 for vocational licences and in August 1994 for ordinary licences.

To be eligible for a group 1 licence (an ordinary licence—that for motorcars and motorcycles) an applicant with epilepsy must have been free of epileptic attacks during the year before the date when the licence is granted (or, if epileptic attacks occur only during sleep, must have had a sleep only pattern for three years or more). In addition, his or her driving must …
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells
Authors: Monica V. Goldberg, Charles H. Maris, Edward L. Hipkiss, Andrew S. Flies, Lijie Zhen, Rubin M. Tuder, Joseph F. Grosso, Timothy J. Harris, Derese Getnet, Katharine A. Whartenby, Dirk G. Brockstedt, Thomas W. Dubensky, Lieping Chen, Drew M. Pardoll, Charles G. Drake
Journal: Blood (2007)
ACUTE OTITIS MEDIATHE NECESSITY OF AN EARLY DIAGNOSIS AND TREATMENT.
Authors: FRANK D. BOYD
Journal: JAMA (1904)

about the joints are ail important.In some patients there is permanent change, dating from-the first attack, in others this may only occur after repeated attacks.These seem comparable to the condition often seen in the endocardium of rheumatic patients.A first attack may leave the valves permanently damaged, or only more liable to involvement in subsequent attacks.Could we determine a definite organism to be asso¬ ciated with the disease, the matter is settled.In this series we have never succeeded in obtaining any results from cultures, in spite of the greatest care in following the methods given (for example, by Bloxall).If we hold the view that many organisms (such as those of in¬ fluenza, gonorrhea, etc.) are etiologic factors, there are many suggestive facts to support this.There seems no doubt of the association of attacks or exacerbations with various infections such as influenza.This may mean ( To be continued.)
Is there a familial association between obstructive sleep apnoea/hypopnoea and the sudden infant death syndrome?
Authors: M Vennelle
Journal: Thorax (2004)

One postulated cause of the sudden infant death syndrome (SIDS) is upper airway obstruction during sleep. Several studies have suggested that SIDS may be more common in families with obstructive sleep apnoea/hypopnoea syndrome (OSAHS), but were limited by uncertainty as to whether the deaths were due to SIDS. We have tested the hypothesis that parents of true SIDS cases have an increased frequency of apnoeas and hypopnoeas during sleep.The parents of 269 rigorously determined SIDS cases were invited for single night polysomnography and daytime ventilatory control measurement.Parents of 198 cases were identified but 152 did not respond or declined. Fifty five parents of 34 cases were studied and matched for age, height, and weight to 55 subjects from general practice registers. There was no difference in breathing during sleep between the parents of SIDS cases (median (IQR) 5.9 (3.2, 10.7) apnoeas+hypopnoeas/h) and controls (6.7 (4.0, 12.2) apnoeas+hypopnoeas/h; p = 0.47), but the SIDS parents had lower minimum nocturnal oxygen saturation (median (IQR) 92 (89, 93)%) than controls (92 (90, 94)%; p = 0.048). There were no major differences in control of breathing when awake between SIDS parents and controls.These results provide no evidence to support an association between SIDS and OSAHS. However, the minor impairment of oxygenation during sleep in SIDS parents requires further study.
Choline Chloride in Infective Hepatitis
Authors: J. S. Richardson, W. S. Suffern
Journal: BMJ (1945)

CHOLINE CHLORIDE IN INFECTIVE HEPATITISMEDBIOISH period of six months before and after treatment, the number of attendances at the surgery for the treatment of sore and bleeding finger-tips fell from 192 to 21.The result of this small series would appear to make further trials on a larger scale worth while.My thanks are due to the management and staff of the Aylesford Paper Mills and Medway Paper Sacks Ltd.
NEW TONSIL CLAMPS
Authors: Mark D. Stevenson
Journal: JAMA (1913)

third hand to retain hold of the tonsil, as the operator's hands are both engaged with the snare.The pistol-handle snares of the Tyding or Peters style overcome the above objections and are becoming increas- ingly popular.But, while they possess the advantages of speed and the use of only one hand in their manipulation, they have the following distinct disadvantages:1. Slow snaring is Impossible should one have occasion
Preventing Death One Stroke at a Time
Authors: Mark J. Alberts
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alterations in guanine nucleotide regulatory protein expression and activity in human hepatocellular carcinoma
Authors: C M Schmidt, I H McKillop, P A Cahill, J V Sitzmann
Journal: Hepatology (1997)

Alterations in the expression and activity of guanine nucleotide regulatory proteins (G proteins) have been linked to the growth of several human tumors. We hypothesized that the expression and activity of G proteins are altered in human hepatocellular carcinoma (HCC). The expression of Gi and Gs proteins was determined in six human tumors and six normal controls (adjacent nonneoplastic liver) by Western blotting using specific antisera raised against the alpha subunit of G proteins Gi1, Gi1-2, Gi3, and Gs. Differences in G-protein expression were quantified by densitometry and expressed as percentage change from normal controls. The expression of Gi alpha1 was significantly increased in 80% of tumors (Gi alpha1, 284% +/- 77%; P < .05 percent of normal tissue), whereas Gi alpha1-2 and Gi alpha3 expression was increased in 67% of tumors (Gi alpha1-2, 218% +/- 21%; Gi alpha3, 154% +/- 6%; P < .05 percent of normal tissue). The functional activity of Gi alpha proteins as determined by pertussis toxin-catalyzed adenosine diphosphate (ADP)-ribosylation was also significantly increased in these tumors. In contrast, Gs alpha-protein expression was significantly reduced in all tumors examined (74% +/- 8% of normal tissue, P < .05). The functional activity of Gs alpha, as determined by adenylyl cyclase (AC) activity, was significantly decreased in tumor as compared to normal liver under both basal and agonist stimulated (guanosine triphosphate gamma S and forskolin) conditions. In summary, these data show for the first time a significant alteration in G-protein expression and functional activity in human HCC tissue. These alterations indicate a down-regulation of the AC-linked enzyme effector system in HCC that may be of critical importance to the formation and progression of human hepatocellular carcinoma.
When authorship fails. A proposal to make contributors accountable
Authors: D. Rennie
Journal: JAMA (1997)

A published article is the primary means whereby new work is communicated, priority is established, and academic promotion is determined. Publication depends on trust and requires that authors be held to standards of honesty, completeness, and fairness in their reporting, and to accountability for their statements. The system of authorship, while appropriate for articles with only 1 author, has become inappropriate as the average number of authors of an article has increased; as the work of coauthors has become more specialized and relationships between them have become more complex; and as both credit and, even more, responsibility have become obscured and diluted. Credit and accountability cannot be assessed unless the contributions of those named as authors are disclosed to readers, so the system is flawed. We argue for a radical conceptual and systematic change, to reflect the realities of multiple authorship and to buttress accountability. We propose dropping the outmoded notion of author in favor of the more useful and realistic one of contributor. This requires disclosure to readers of the contributions made to the research and to the manuscript by the contributors, so that they can accept both credit and responsibility. In addition, certain named contributors take on the role of guarantor for the integrity of the entire work. The requirement that all participants be named as contributors will eliminate the artificial distinction between authors and acknowledgees and will enhance the integrity of publication.
HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1
Authors: Marcus Altfeld, Elizabeth T Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N Johnston, Nicole Burgett, Martha E Swartz, Amy Yang, Galit Alter, Xu G Yu, Angela Meier, Juergen K Rockstroh, Todd M Allen, Heiko Jessen, Eric S Rosenberg, Mary Carrington, Bruce D Walker
Journal: PLoS Medicine (2006)

Background Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression. Methods and Findings In a cohort of 104 individuals with primary HIV-1 infection, we demonstrate that a subset of CD8+ T cell epitopes within HIV-1 are consistently targeted early after infection, while other epitopes subsequently targeted through the same HLA class I alleles are rarely recognized. Certain HLA alleles consistently contributed more than others to the total virus-specific CD8+ T cell response during primary infection, and also reduced the absolute magnitude of responses restricted by other alleles if coexpressed in the same individual, consistent with immunodomination. Furthermore, individual HLA class I alleles that have been associated with slower HIV-1 disease progression contributed strongly to the total HIV-1-specific CD8+ T cell response during primary infection. Conclusions These data demonstrate consistent immunodominance patterns of HIV-1-specific CD8+ T cell responses during primary infection and provide a mechanistic explanation for the protective effect of specific HLA class I alleles on HIV-1 disease progression.
LOSS OF VITREOUS IN CATARACT EXTRACTION
Authors: EDWIN BLAKESLEE DUNPHY
Journal: JAMA (1927)

This paper is a survey of 2,560 cataract extractions performed at the Massachusetts Eye and Ear Infirmary between Jan. 1, 1915, and Jan. 1, 1925. This number does not include operations for traumatic or congenital cataract: it covers simply the ordinary senile cases. The object of this survey is twofold: (1) to find out whether or not loss of vitreous at operation really makes much practical difference to the patient in after years, and (2) to classify the complications occurring in the several types of cataract operations. The method employed was the study of the case records of all senile cataract operations for a ten-year period; and then, by follow-up letter and personal examination, a study of as many as possible of the cases in which vitreous had been lost. It is realized, of course, that in this series the operators were men of differing experience. Some were chief surgeons,
Cutaneous leishmaniasis: evaluation of 3074 cases in the Çukurova region of Turkey
Authors: None UZUN, None USLULAR, None YÜCEL, None ACAR, None ÖZPOYRAZ, None MEMİŞOĞLU
Journal: British Journal of Dermatology (1999)

A total of 3,074 cases of cutaneous leishmaniasis was evaluated for demography, diagnosis, clinical characteristics and treatment. A peak in the number of cases was observed in 1991 and 1992, with a total of 1,550 cases. There were seasonal differences in frequency, the highest levels being recorded during the period October-December each year. The disease was more frequent in females (59%) and in the age group 10-19 years (41%). More than 80% of 4394 lesions were located on exposed body sites, and most patients (87%) had the acute form of the disease. Diagnosis was made by the smear method in 90% of cases. Treatment was by intralesional injection of antimony compounds in 76% of cases. Cryotherapy was used in most of the remaining cases, either alone or combined with intralesional injection of antimony compounds. The overall healing rate was over 90%.
Unprocessed Bran in Treatment of Diverticular Disease of the Colon
Authors: N. S. Painter, A. Z. Almeida, K. W. Colebourne
Journal: BMJ (1972)

Seventy patients with diverticular disease of the colon were treated with a high-residue, low-sugar diet including unprocessed bran. Follow-up for an average of 22 months showed marked relief of symptoms in 62 patients. Bowel habit was restored towards normal and abdominal discomfort relieved. Only seven patients were unable to give up the use of laxatives. Eight patients did not tolerate the bran diet, and one of these needed surgical treatment. None of the 62 patients who took the diet needed surgery.
Emergency Physicians In Demand
Authors: Mike Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cell proliferation in the gastric corpus in Helicobacter pylori associated gastritis and after gastric resection.
Authors: D A Lynch, N P Mapstone, A M Clarke, P Jackson, M F Dixon, P Quirke, A T Axon
Journal: Gut (1995)

Patients who have undergone gastric resection are at higher risk of developing gastric carcinoma than normal subjects, and bile reflux is believed to play a role in carcinogenesis. An increase in mucosal cell proliferation increases the likelihood of a neoplastic clone of epithelial cells emerging, particularly where there is chronic epithelial injury associated with bile reflux. Helicobacter pylori is considered a major risk factor for gastric cancer in the intact stomach. It has been shown previously that antral cell proliferation is increased in H pylori gastritis and falls to normal levels after eradication of the organism. Little is known of corpus cell proliferation in H pylori gastritis or after gastric resection. Using in vitro bromodeoxyuridine labelling of endoscopic biopsy specimens we have found that corpus cell proliferation is increased in H pylori gastritis. Cell proliferation was greater in corpus biopsy specimens of resected stomachs than in H pylori gastritis. Subgroup analysis of patients who had undergone gastric resection indicated that those positive for H pylori had higher levels of cell proliferation than those negative for the organism. These findings provide further evidence that H pylori and bile have a role in gastric carcinogenesis and suggest that their presence has a synergistic effect on gastric epithelial cell proliferation.
Counting on Quality: A Medical Audit Workbook
Authors: L Pike
Journal: BMJ (1994)

Oliver Samuel, Paul Sackin, Bonnie Sibbald Royal college of General Practitioners, £ 13.50, pp 115 ISBN 0-85084-189-5

Doctors on the whole are not in the business of counting, unless it has to do with income generation. Decades ago the ability to diagnose and treat illness took precedence over counting the numbers of cases diagnosed or the cost of treatment. The establishment of the College of General Practitioners put an academic face on to general practice. Doctors were able to collaborate in collecting information about such things as the prevalence and incidence of disease, enabling for the …