The Interaction of Hereditary Persistence of Fetal Hemoglobin and Beta Thalassemia
Authors: GARY A. BECKER
Journal: Annals of Internal Medicine (1966)

Case Studies1 November 1966The Interaction of Hereditary Persistence of Fetal Hemoglobin and Beta ThalassemiaGARY A. BECKER, M.D., ENNIO C. ROSSI, M.D.GARY A. BECKER, M.D.Search for more papers by this author, ENNIO C. ROSSI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1071 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHereditary persistence of fetal hemoglobin was first noted in 1955 by Edington and Lehmann (1). Subsequently, this condition was found in African and American Negroes (2-4), in a Portuguese-Indian family in England (5), and in Caucasians of Italian (6) and Greek ancestry (7). Conley and associates (8) found hereditary persistence of fetal hemoglobin in about 0.1% of the Negro population in Baltimore. Recently, this prevalence was confirmed by Thompson, Warrington, Odom, and Bell (9) in a survey of 12,000 Negroes in the southern United States. Thus, far more than 100 cases of hereditary persistence of fetal hemoglobin have been reported....References1. EDINGTONLEHMANN GMH: Expression of the sickle cell gene in Africa. Brit. Med. J. 1: 1308, 1955. CrossrefMedlineGoogle Scholar2. JACOBRAPER GFAB: Hereditary persistence of foetal haemoglobin production and its interaction with the sickle-cell trait. Brit. J. Haemat. 4: 138, 1958. CrossrefMedlineGoogle Scholar3. WHEELERKREVANS JTJR: The homozygous state of persistent fetal hemoglobin and the interaction of persistent fetal hemoglobin with thalassemia. Bull. Hopkins Hosp. 109: 217, 1961. MedlineGoogle Scholar4. THOMPSONMITCHENERHUISMAN RBJWTH: Studies on the fetal hemoglobin in the persistent high Hb-F anomaly. Blood 8: 267, 1961. CrossrefGoogle Scholar5. BARKHANADINOLFI PM: Observations on the high foetal haemoglobin gene and its interaction with the thalassaemia trait. J. Clin. Path. 15: 350, 1962. CrossrefMedlineGoogle Scholar6. MANGANELLIDALFINOTANNOIA GGN: Su di un caso di associazione tra thalassemia e "persistenza ereditaria di emoglobina fetale." Haematologica 47: 353, 1962. MedlineGoogle Scholar7. FESSAS P: Hereditary persistence of foetal haemoglobin and its combination with alpha- and with beta-thalassemia, in Haemoglobin Colloquium, edited by LEHMANN, H., BETKE, K. Wien, Stuttgart, 1962, p. 82. Google Scholar8. CONLEYWEATHERALLRICHARDSONSHEPARDCHARACHE CLDJSNMKS: Hereditary persistence of fetal hemoglobin: a study of 79 affected persons in 15 Negro families in Baltimore. Blood 21: 261, 1963. CrossrefMedlineGoogle Scholar9. THOMPSONWARRINGTONODOMBELL RBRJWN: Interaction between genes for delta thalassemia and hereditary persistence of foetal haemoglobin. Acta Genet. (Basel) 15: 190, 1965. MedlineGoogle Scholar10. WEATHERALL DJ: The Thalassemia Syndromes. F. A. Davis, Co., Philadelphia, 1965, p. 144. Google Scholar11. BETKEKLEIHAUER KE: Fetaler und bleibender blufarbstaff in erythrocyten und erythroblasten von menschlichen fetan und neugelbarenen. Blut 4: 241, 1958. CrossrefMedlineGoogle Scholar12. GABUZDANATHANGARDNER TGDGFH: Thalassemia trait. Genetic combinations of increased fetal and A2 hemoglobin. New Eng. J. Med. 270: 1212, 1964. CrossrefMedlineGoogle Scholar13. FESSAS P: Beta-chain thalassemias, in Haemoglobin Colloquium, edited by LEHMANN, H., BETKE, K. Wien, Stuttgart, 1962, p. 90. Google Scholar14. ZUELZERROBINSONBOOKER WWARCR: Reciprocal relationship of hemoglobins A2 and F in beta chain thalassemias, a key to the genetic control of hemoglobin F. Blood 17: 393, 1961. CrossrefMedlineGoogle Scholar15. GERALD PS: Genetic determination of hemoglobin structure. Medicine (Balt.) 43: 747, 1964. CrossrefMedlineGoogle Scholar16. INGRAM VM: The Hemoglobins in Genetics and Evolution. Columbia University Press, New York, 1963, p. 119. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, WisconsinFrom the Marquette University School of Medicine and the Blood Research Laboratory, Milwaukee County General Hospital, Milwaukee, Wis.This work was supported in part by training grant T1 AM 5162, the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.Dr. Becker is a Trainee in Hematology, the Marquette University School of Medicine, Milwaukee, Wis.Requests for reprints should be addressed to Gary A. Becker, M.D., 8700 W. Wisconsin Ave., Milwaukee, Wis. 53226. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNormal and Abnormal Human Hemoglobins 1 November 1966Volume 65, Issue 5Page: 1071-1075KeywordsAttentionBeta-thalassemiaBloodGeneticsHematology and oncologyHemoglobinHospital medicineMetabolic disordersResearch laboratoriesThalassemia Issue Published: 1 November 1966 PDF DownloadLoading ...