Alcohol and Pancreatitis
Authors: HENRY D. JANOWITZ
Journal: Annals of Internal Medicine (1971)

Editorial Notes1 March 1971Alcohol and PancreatitisHENRY D. JANOWITZ, M.D., MICHAEL BAYER, M.D.HENRY D. JANOWITZ, M.D.Search for more papers by this author, MICHAEL BAYER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-3-444 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe parodox of pancreatitis is that we know much of its etiology but very little about its pathogenesis. A list of associated etiologic factors include biliary tract disease, alcoholism, some disorders of calcium metabolism (especially hyperparathyroidism), hyperlipoproteinemia, specific viral infections, pregnancy, mechanical duodenal obstruction, surgical and external abdominal trauma, and various reactions to drugs (isoniazid, chlorothiazide) among others. All investigators in this area assume in common, however, that the fundamental factor in acute pancreatitis ( and, by inference, in the recurrent and chronic forms) is autodigestion of the gland by its activated enzymes. The recent review by Creutzfeldt and Schmidt...References1. CREUTZFELDTSCHMIDT WH: Etiology and pathogenesis of pancreatitis. Scand J Gastroent 5(suppl 6):47-62, 1970 Google Scholar2. MCCUTCHEON A: A fresh approach to pathogenesis of pancreatitis. Gut 9:296-310, 1968 CrossrefMedlineGoogle Scholar3. DAVISPIROLA AR: The effects of ethyl alcohol on pancreatic exocrine function. Med J Aust 2:757-760, 1966 CrossrefMedlineGoogle Scholar4. PIROLADAVIS RA: Effects of intravenous alcohol on motility of the duodenum and on the sphincter of Oddi. Aust Ann Med 1:24-29, 1970 Google Scholar5. DARLEEKHOLMEDLUND NRY: Ultrastructure of the rat exocrine pancreas after long term intake of ethanol. Gastroenterology 58:62-70, 1970 CrossrefMedlineGoogle Scholar6. ORREGO-MATTENAVIAFERES HEA: Ethanol ingestion and incorporation of P32 into phospholipids of pancreas in the rat. Gastroenterology 56:280-285, 1969 CrossrefMedlineGoogle Scholar7. CLAYMANSWAMINATHANSCHOLEFELD SVP: Transport and exchange diffusion of amino acids by in vitro preparation of pancreas from normal, tumor-bearing and alcohol treated mice. Biochem Biophy Res Commun 31:553-557, 1968 CrossrefMedlineGoogle Scholar8. LIEBER C: Hepatic and metabolic effects of alcohol. Gastroenterology 52:119-133, 1966 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Mount Sinai School of Medicine New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe effect of acute ethanol administration on the exocrine pancreatic secretion of the pigDemographic Characteristics of Hospitalized Patients With Alcoholic Liver Disease and Pancreatitis in Los Angeles CountyComorbid occurrence of liver and pancreas disease in United States military veteransRole of nonpancreatic lipolytic activity in exocrine pancreatic insufficiencyGastrointestinal and hepatic manifestations of chronic alcoholismAlcohol and Acute PancreatitisAlcohol and the upper gastrointestinal tract and pancreasEffect of ethanol on ultrastructure of the pancreatic aciniCirrhosis, Glucagon and PancreatitisAlcoholism and MalnutritionInhibitory Effect of Ethanol on Canine Exocrine Pancreatk Secretion 1 March 1971Volume 74, Issue 3Page: 444-445KeywordsDrugsEnzymesEtiologyHyperparathyroidismInfectious diseasesIsoniazidPancreatitisPathogenesisPregnancyViral diseases Issue Published: 1 March 1971 PDF DownloadLoading ...