tbuckley/cabot-search huggingface dataset:
Getting real about experience
Authors: Inez Myin-Germeys, Erik Myin
Journal: Behavioral and Brain Sciences (2004)

The idea that experience is essentially subjective rather than of the real world is paradoxical and deeply flawed. The external world is, much more than a mere constraint, essential to meaningfully describe experience and neural activity. This is illustrated by an analysis of the phenomenology of veridical perception and by the study of experience in psychopathology by the Experience Sampling Method (ESM).
Influence of capecitabine absorption on its metabolites pharmacokinetics: a bioequivalence study
Authors: L. Chaigneau, B. Royer, D. Montange, T. Nguyen, T. Maurina, C. Villanueva, M. Demarchi, C. Borg, C. Fagnoni-Legat, J.-P. Kantelip, X. Pivot
Journal: Annals of Oncology (2008)
Monozygous twins concordant for duodenojejunal villous atrophy and dermatitis herpetiformis.
Authors: S T Green, S Natarajan, J M Connor, J A Forrest
Journal: Gut (1986)

A pair of monozygous twins concordant for both duodenojejunal villous atrophy and dermatitis herpetiformis are described, the first example to be reported in the literature. The observation provides strong support for the concept of an underlying genetic component being involved in the pathogenesis of these two conditions.
The Treatment of Wounds of the Air Passages
Authors: J. E. Platt
Journal: BMJ (1897)

THis subject does not appear to have received quite so mitch attention as it merits, and hence, having had opportunities of observing an unusually large number of cases, I venture to record my results, together with a brief account of certain improved details of treatment.Until a few years ago almost all authorities discountenanced the use of sutures in wounds opening the air passage.The risks to the patient were thereby greatly increased, and death often occurred from ,septic broncho-pneumonia or other inflammatory complica- tion; at the best convarlescence was tardy, and permanent afrial fistula or stenosis of the larynx or trachea frequently resulted.In I892, however, Henry Morris' recorded a number of cases in which he had applied sutures with success, and Pollard2 advocated the same treatment; but although other -surgeons have from time to time reported isolated successful eases, it would appear that a large number of these wounds axe still treated by the older method of non-suture.During the two years whilst I was resident surgical officer at the Manchester Royal Infirmary 35 patients sufering from suicidal wounds of the throat were admitted to that institu- tion.In io of the number the air passages were injured, and in 25 the wound was comparatively superficial.A brief out- line of the cases in which the air passage was opened, is as follows:CASE I.-Male, aged 55, admitted December 7th, 1894.Large woundabove hyoid bone reaching on left side to posterior border of sterno-mastoid mnusele.Genio-hyoid and genio-glossi muscles divided.and pharynx opened.No sutures appliecdwound packed with lint soaked in warm lotion, and patient placed in a steam tent.He sank gradually, and died fromheart failure eight days after admission.CASE In.-Male, aged 34, alcoholic, admitted June Ioth, 1895.Wound of thyro-hyoid membrane.Aperture in larynx closed by catgut sutures; also skin, except slightly at angles of incision no tracheotomy tube used.Wound healed by first intention; never any rise of temperature; patient discharged ten days after accident quite well.Fifteen months later I heard that he had had no further trouble from his throat, andwas in good health.CASE iI.-Male, aged 52, admitted June s8th, i895.Skin wound 3 inches long; cut through thyroid cartilage into larynx 1 inch long; second cut through crico-thyroid membrane I inch long.Wound in thyroid car- tilage closed by one suture; silver tracheotomy tube introduced through opening in crico-thyroid membrane and rest of wound closed around it.Tube removed on fourth day; the opening left by it was nearly a month in closing.There were never any bad symptoms.The patient was seen fifteen months afterwards, and he was then quite well, and had had no subsequent trouble from his throat.CASE iv.-Male, aged 32, admitted October 5th, 1895.Wound 5 inches ong; left sterno-mastoid three-fourths divided, right sterno-mastoid half divided.Thyro-hyoid membrane close to thyroid cartilage opened for inch.High tracheotomy performed; wound in larynx closed.Some
Functional Interplay of p53 and Mus81 in DNA Damage Responses and Cancer
Authors: Ashwin Pamidi, Renato Cardoso, Anne Hakem, Elzbieta Matysiak-Zablocki, Anuradha Poonepalli, Laura Tamblyn, Bayardo Perez-Ordonez, M. Prakash Hande, Otto Sanchez, Razqallah Hakem
Journal: Cancer Research (2007)

Abstract Mus81 plays an integral role in the maintenance of genome stability and DNA repair in mammalian cells. Deficiency of Mus81 in human and mouse cells results in hypersensitivity to interstrand cross-linking (ICL) agents and elevated levels of genomic instability. Furthermore, Mus81-mutant mice are susceptible to spontaneous lymphomas. The role of cellular checkpoints in mediating the phenotypes observed in Mus81-deficient cells and mice is currently unknown. In this study, we have observed increased activation of p53 in Mus81−/− cells in response to ICL-induced DNA damage. In addition, p53 inactivation completely rescued the ICL hypersensitivity of Mus81−/− cells, signifying p53 is essential for the elimination of ICL-damaged cells in the absence of Mus81. Confirming that p53 acts as a critical checkpoint for the Mus81 repair pathway, a synergistic increase of spontaneous and ICL-induced genomic instability was observed in Mus81−/−p53−/− cells. To clarify the genetic interactions of Mus81 and p53 in tumor suppression, we monitored Mus81−/−p53−/− and control mice for the development of spontaneous tumors. Significantly, we show that loss of even a single allele of Mus81 drastically modifies the tumor spectrum of p53-mutant mice and increases their predisposition to developing sarcomas. Our results reveal a key role for p53 in mediating the response to spontaneous and ICL-induced DNA damage that occurs in the absence of Mus81. Furthermore, our data show that loss of Mus81, in addition to p53, is a key step in sarcoma development. [Cancer Res 2007;67(18):8527–35]
Clinical Use of Psychotherapeutic Drugs
Authors: Frank J. Ayd
Journal: JAMA (1973)

The author of this book is a clinical investigator whose research with psychotherapeutic and other drugs has been respected for its scientific excellence for the past two decades. His wisdom, astute observations, and ability to communicate the essence of his vast research and clinical experience clearly and succinctly are evident throughout this latest addition to his extensive bibliography.  This superior, up-to-date book covers all the psychoactive drugs physicians prescribe—the neuroleptics or major tranquilizers, the minor tranquilizers, the antidepressants, and lithium carbonate—including the use of some of these agents in children and in the treatment of psychoses associated with old age. There also is a brief discussion of the management of alcoholism (acute and chronic), and the abuse of sedative-hypnotic drugs. Each chapter on the various categories of drugs consists of an incisive commentary on clinical indications, contemporary theories on the biochemical disturbances underlying these disorders, the essential pharmacological facts about
Key players express doubt over whether health bill amendments will restrict competition in NHS
Authors: M. Limb
Journal: BMJ (2011)

Monitor, whose role was expanded in the Health and Social Care Bill from economic regulator of foundation trusts to economic regulator of the entire NHS, will put patients’ interests first in judging whether competition is beneficial and act to stop market abuses, its chairman has told a conference.

The UK Future Forum had insisted that competition should be dropped as Monitor’s primary duty. Instead, competition should be used as a tool for supporting choice, promoting integration, and improving quality and must never be pursued as an end in itself. 

David Bennett, who is also acting as interim chief executive of Monitor, confirmed the forum’s recommendations. He said that the organisation would be able to facilitate competition and to encourage integration where appropriate and insisted that these aims were not contradictory, as some critics have said. 

“Competition and cooperation are not mutually exclusive. We believe they can coexist,” he said. Monitor is due to take on the role of economic regulator in October 2012, subject to the health bill being passed.

Dr Bennett was the headline speaker …
Management of Acute Respiratory Failure in Bronchitis and Emphysema with Observations on Controlled Oxygen Therapy.
Authors: James P. Smith
Journal: Annals of Internal Medicine (1967)

s1 May 1967Management of Acute Respiratory Failure in Bronchitis and Emphysema with Observations on Controlled Oxygen Therapy.James P. Smith, M.D., Richard W. Stone, M.D., Carl Muschenheim, M.D., F.A.C.P.James P. Smith, M.D.Search for more papers by this author, Richard W. Stone, M.D.Search for more papers by this author, Carl Muschenheim, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1056_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMortality from acute respiratory failure in patients with chronic obstructive lung disease remains high (18 to 70%) in reported series. The possibility that the discouraging results of treatment are related in part to the widely recommended use of mechanical respirators has prompted an evaluation of a more conservative approach to therapy in patients with severe failure (Paco2, 55 mm Hg or more; arterial pH, 7.35 or less; and arterial oxygen saturation (SaO2), 85% or lower).Precisely controlled oxygen, delivered according to the principle of high airflow with oxygen enrichment (Ventimask), and intensive supportive measures are used as initial therapy for... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: James P. Smith, M.D.; Richard W. Stone, M.D.; Carl Muschenheim, M.D., F.A.C.P.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUse of a Pressure-Cycled Respirator (Bird) in Respiratory Failure Due to Severe Obstructive Pulmonary DiseaseMARGARET BILLINGHAM, M.B.B.S. (LOND.), FREDERIC ELDRIDGE, M.D., F.A.C.P.Effect of Oxygen Administration by a Venturi Apparatus on Arterial Blood Gas Values in Patients with Respiratory Failure 1 May 1967Volume 66, Issue 5Page: 1056-1057KeywordsBronchitisChronic obstructive pulmonary diseaseEmphysemaLungsMortalityOxygenRespiratorsRespiratory failure ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
Spiral Nitinol Biliary Stents in a Porcine Model: Evaluation of the Potential for Use in Benign Strictures
Authors: E. C. Van Os, B. T. Petersen, K. P. Batts
Journal: Endoscopy (1999)

Self-expanding spiral nitinol stents are potentially removable and may be useful in the treatment of benign strictures. We evaluated the histologic response to stent placement and technical aspects of their placement and removal in a porcine model.Nine animals were studied. Stents were placed above the papilla in six surviving animals. After intervals of one, two or three months cholangiography and attempted stent removal was performed. Four animals were then sacrificed acutely with their stent in place, and two were sacrificed after a one-month healing interval. The results of placement, follow-up cholangiography and histology are reported.Cholangiography and stent placement succeeded in 26 of 27 and 11 of 16 attempts, respectively. Three placement failures were attributed to stent/duct size disparity or a faulty release mechanism, resulting in stent kinking and/or duct twisting. Among the successfully deployed stents, two animals developed strictures where stents traversed bifurcations and one exhibited partial luminal compromise by tissue entrapment between coils. Fluoroscopically guided removal was successful in two of five stents positioned above the papilla. Histology was non-specific but minimally changed in those given a one-month healing interval after removal. Others exhibited moderate inflammation, fibrosis and an intramural abscess at sites of induced stricture.Spiral metal stents for the treatment of benign strictures remain experimental. Care must be taken to deploy them in bile ducts of adequate diameter and endoscopic removal is not yet demonstrably reliable and safe.
Gastroptosia Not Gastroptosis. Perityphlitis Not Appendicitis.
Authors: H. O'Donnel Parks
Journal: JAMA (1902)

Ashton, R. I., Aug. 16, 1902. <h3>To the Editor:</h3> —In to-day's issue your correspondent, A. Rose, in my judgment, raises a tempest in a teapot about nothing. In a very learned analysis he condemns the use of the word appendicitis and prefers perityphlitis instead. I think the learned gentleman's labors waste themselves on mere logomachy. In my opinion the term "appendicitis" describes the condition sufficiently well for all practical purposes. He prefers perityphlitis, which means inflammation around, peri (πϵρ[unk]) the cecum, tuphlon (τυϕλον) blind. Now, the appendix is not about the cecum but directly attached to it, and there is no doubt but that the term appendicitis describes the condition accurately: If Dr. Rose is not satisfied etymologically why not call it epityphlitis, epi (ϵπ[unk]), on or attached to the cecum, tuphlon (τυϕλον). Or perhaps he objects to the term appendicitis as being a hybrid word, half Latin, half Greek,
Intraaortic Balloon Pumping for Control of Recurrent Myocardial Ischemia
Authors: HERMAN K. GOLD, ROBERT C. LEINBACH, CHARLES A. SANDERS, MORTIMER J. BUCKLEY, ELDRED D. MUNDTH, W. GERALD AUSTEN
Journal: Circulation (1973)

Eleven patients were studied because of recurrent angina at rest. In five cases ischemic pain developed 3-10 days after acute myocardial infarction. Pain recurred in all cases despite therapy with bedrest, oxygen, heparin anticoagulation, nitrates, and whenever possible, beta blockade. Intraaortic balloon pumping with a 30-cc balloon prevented ischemia in nine patients and markedly reduced the frequency of ischemic attacks in two. Coronary angiograms were obtained during circulatory assistance without complication and confirmed proximal coronary artery obstructions in all patients. Saphenous vein aortocoronary bypass grafting was then performed. Intraaortic balloon pumping will effectively control myocardial ischemia resistant to medical therapy.
Improvement of tissue-adhesive obliteration of bleeding gastric varices using adjuvant hypertonic glucose injection: a prospective randomized trial
Authors: M.-J. Kuo, H.-Z. Yeh, G.-H. Chen, S.-K. Poon, S.-S. Yang, H.-C. Lien, C.-S. Chang
Journal: Endoscopy (2007)

See also: Commentaire de travail de M.-J. Kuo et al., pp. 487Endoscopy 2007; 39(06): 576-576DOI: 10.1055/s-0032-1306937
Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling
Authors: Linlin Wang, Thomas C. Schulz, Eric S. Sherrer, Derek S. Dauphin, Soojung Shin, Angelique M. Nelson, Carol B. Ware, Mei Zhan, Chao-Zhong Song, Xiaoji Chen, Sandii N. Brimble, Amanda McLean, Maria J. Galeano, Elizabeth W. Uhl, Kevin A. D'Amour, Jonathan D. Chesnut, Mahendra S. Rao, C. Anthony Blau, Allan J. Robins
Journal: Blood (2007)
Measurement of Emotional Adjustment in Diabetic Patients: Validity and Reliability of ATT39
Authors: S M Dunn, H H Smartt, L J Beeney, J R Turtle
Journal: Diabetes Care (1986)

The ATT39 scale was developed as a norm-referenced measure of emotional adjustment in diabetic patients. Scores on three parallel forms of the parent scale changed in response to educational intervention, and the change in scores was predictive of subsequent improvement in metabolic control. We describe further reliability and validity studies with six factorially derived subscales of the ATT39, which measured perceived levels of stress, adaptation, guilt, alienation, illness conviction, and tolerance for ambiguity. Internal consistency (Cronbach alpha) of the unweighted total score was 0.78, and the Guttman lower bound estimate of reliability was 0.86. The test-retest reliability of the total score varied from 0.70 to 0.87, over intervals of 2 wk, 3 mo, and 6 mo, and reliability coefficients for the six factor scores averaged 0.56. ATT39 factor scores, in 134 insulin-dependent diabetes mellitus (IDDM) and 166 non-insulin-dependent diabetes mellitus (NIDDM) patients, were correlated with scores on the Cattell 16 personality factor questionnaire and the locus of control of behavior scale (LCB). In IDDM, age was related to better adaptation, increased feelings of guilt, and a more cooperative attitude to staff and treatment. In NIDDM, age was associated with increasing resignation to a conviction of chronic illness and less tolerance for the ambiguities involved in diabetes. Intelligence was correlated with less guilt and more tolerance. Anxiety was associated with significant diabetes-related stress, regardless of treatment, and with poorer adaptation and guilt in NIDDM. An external LCB was related to increased stress and guilt. The results confirm that emotional adjustment in diabetes involves dynamic interactions among feelings that are relatively stable over periods up to 6 mo and that relate meaningfully to other aspects of personality functioning.
Abstract 2162: Gene expression profile for predicting survival in ovarian cancer across two independent datasets
Authors: Kosuke Yoshihara, Atsushi Tajima, Tetsuro Yahata, Shoji Kodama, Hiroyuki Fujiwara, Mitsuaki Suzuki, Yoshitaka Onishi, Masayuki Hatae, Kazunobu Sueyoshi, Hisaya Fujiwara, Yoshiki Kudo, Kohei Kotera, Hideaki Masuzaki, Hironori Tashiro, Hidetaka Katabuchi, Ituro Inoue, Kenichi Tanaka
Journal: Cancer Research (2010)

Abstract Advanced-stage ovarian cancer patients are generally treated with platinum/taxane-based chemotherapy after primary debulking surgery. However, there is a wide range of outcomes for individual patients. Therefore, the clinicopathological factors alone are insufficient for predicting prognosis. To identify a progression-free survival (PFS) related profile for predicting survival, advanced-stage serous ovarian cancer tissues from 110 patients who underwent primary surgery and platinum/taxane-based chemotherapy were profiled using oligonucleotide microarrays. We first selected 88 PFS-related genes by a univariate Cox model (p &amp;lt; 0.01). To avoid overfitting our dataset, we then adjusted regression coefficients of the genes by ridge regression Cox model using 10-fold cross-validation. The prognostic index for each patient based on the 88-gene expression profile with the estimated coefficients was significantly correlated with PFS time as a continuous variable. In multivariate analysis, the prognostic index was independently associated with PFS time compared to other clinical factors [hazard ratio (HR), 4.84; 95% confidence interval (CI), 3.50-6.55; p &amp;lt; 0.001]. This prognostic ability was validated using an external validation dataset (n = 87) and proven by multivariate analysis (HR, 1.25; 95% CI, 1.08-1.45; p = 0.0032). The correlation between the prognostic index and overall survival time was confirmed in the two independent datasets. Furthermore, biological characterization of 88 PFS-related genes mainly highlighted several oncogenic signaling pathways. This PFS-related profile is the first step toward clinical practice for optimizing clinical management for advanced-stage serous ovarian cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2162.
Acquisition of Murine NK Cell Cytotoxicity Requires the Translation of a Pre-existing Pool of Granzyme B and Perforin mRNAs
Authors: Todd A. Fehniger, Sheng F. Cai, Xuefang Cao, Andrew J. Bredemeyer, Rachel M. Presti, Anthony R. French, Timothy J. Ley
Journal: Immunity (2007)
Suctioning through a double-lumen endotracheal tube helps to prevent alveolar collapse and to preserve ventilation
Authors: Hajo Reissmann, Stephan H. Böhm, Fernando Suárez-Sipmann, Gerardo Tusman, Claas Buschmann, Stefan Maisch, Tanja Pesch, Oliver Thamm, Christoph Plümers, Jochen Schulte am Esch, Göran Hedenstierna
Journal: Intensive Care Medicine (2005)
1031-108 The role of a common adenosine monophosphate deaminase-1 polymorphism in outcome of ischemic and nonischemic heart failure
Authors: Matthew J Kolek, John F Carlquist, Surai Thaneemit-Chen, Bryant M Whiting, Benjamin D Horne, Joseph B Muhlestein, Philip Lavori, Jeffrey L Anderson
Journal: Journal of the American College of Cardiology (2004)
Role of hepatic arterial embolisation in the carcinoid syndrome.
Authors: P N Maton, M Camilleri, G Griffin, D J Allison, H J Hodgson, V S Chadwick
Journal: BMJ (1983)

Eighteen patients with severe symptoms of the carcinoid syndrome were assessed for hepatic embolisation. Four were too ill, and one had mild symptoms; thus 13 received a periembolisation regimen of cyproheptadine, fenclonine, aprotinin, methylprednisolone, tobramycin, flucloxacillin, and metronidazole. Embolisation was not performed in one patient with an occluded portal vein and was unsatisfactory in two others, in one because she was moribund and in the other because the hepatic artery had been ligated. Dramatic improvement in symptoms occurred in the nine patients in whom embolisation was successfully carried out, with abolition of flushing, severe abdominal pain, and wheeze and reduction in diarrhoea from 10.5 (SD 7.6) to 1.6 (0.9) stools/day. Urinary excretion of 5-hydroxyindole acetic acid fell from 1048 (716) to 289 (184) mumol/24 h (200 (137) to 55 (35) mg/24 h). Complications included one death from septicaemia, a hepatic abscess requiring surgical drainage, abdominal pain in three patients, pleural effusion in two, and transient encephalopathy in one. Relief of symptoms lasted for one to 24 months, and second embolisation in two patients produced further remissions of four to six months. Five patients died, one to 40 months after embolisation, in four cases because of metastases or heart failure. Hepatic embolisation is the treatment of choice for symptoms of the carcinoid syndrome resistant to medical treatment.