tbuckley/cabot-search huggingface dataset:
Toxoplasma Sortilin-like Receptor Regulates Protein Transport and Is Essential for Apical Secretory Organelle Biogenesis and Host Infection
Authors: Pierre-Julien Sloves, Stephane Delhaye, Thomas Mouveaux, Elisabeth Werkmeister, Christian Slomianny, Agnes Hovasse, Tchilabalo Dilezitoko Alayi, Isabelle Callebaut, Rajshekhar Y. Gaji, Christine Schaeffer-Reiss, Alain Van Dorsselear, Vern B. Carruthers, Stanislas Tomavo
Journal: Cell Host & Microbe (2012)
Safety and antiviral activity of emtricitabine (FTC) for the treatment of chronic hepatitis B infection: A two-year study
Authors: Robert G. Gish, Huy Trinh, Nancy Leung, Francis K.L. Chan, Michael W. Fried, Teresa L. Wright, Chia Wang, Jane Anderson, Elsa Mondou, Andrea Snow, Jeff Sorbel, Franck Rousseau, Lawrence Corey
Journal: Journal of Hepatology (2005)
ACUTE ASCENDING PARALYSIS AND LANDRY'S PARALYSIS.
Authors: L. HARRISON METTLER
Journal: JAMA (1904)

At the present time there is much confusion of thought, and not a little conflict of statement, as to exactly what is meant by Landry's paralysis and as to the true nature of the disease. Landry's paralysis and acute ascending paralysis are by no means always the same, and yet the terms are used synonymously. There must be a middle ground whereon they overlap to warrant this synonymous use of the two names. A clear conception of the nature of this middle ground, from both the clinical and pathologic points of view, will not only go far toward explaining the dissimilar cases lying outside of it and on either hand, but it will help to accomplish what is of far more practical immportance, for it will afford greater unity, definiteness and coherency in the treatment of all cases. The purpose of this paper is to clear up a little, if
A103: Childhood Onset Takayasu Arteritis-Experience From a Tertiary Care Centre in South India
Authors: Sathish Kumar, Ruchika Goel, Debashish Danda, Ajith Kumar Surin, Paul A Bacon
Journal: Arthritis & Rheumatology (2014)

Background/Purpose:

Takayasu Arteritis (TA) is a chronic granulomatous vasculitis of autoimmune etiology characterized by narrowing of aorta and its main branches. It is one of the rarest diseases but the third common cause of vasculitis in pediatric age group. Mortality in juvenile onset TA has been reported to range from 8% to 35%. The outcome of disease has improved recently with interdisciplinary treatment including immunosuppressants and cardiovascular interventional procedures. We aimed to study the clinical features, angiographic findings and outcome of children with TA referred to a single centre in South India over a 9 year period.



Methods:

Records of TA patients, with symptom onset prior to 16 years of age were studied. Disease Extent Index-Takayasu (DEI.TAK), Indian Takayasu Arteritis Score 2010, and Takayasu Arteritis Damage Score (TADS) were calculated retrospectively using clinical information in electronic records. Cumulative incidence of sustained remission was estimated using Kaplan Meir curve



Results:

Forty patients with childhood onset TA with median age of onset of 12.5 (range 1–16) years presented at a median diagnostic delay of 11.3 (range 1–60) months. Commonest presenting features were hypertension, headache, malaise and fever. Pulse-less disease was observed in 25 (62.5%) cases. Majority (n = 28) had active disease with raised inflammatory markers, high baseline DEI.TAK score of 10 (3–24) and high median TADS of 7 (3–14).



Of the 34 patients, followed up for 21.5 (range 3–192) months, remission was attained in 30, however cumulative sustained remission was achieved in only 29% of them at 5 years. Median period of sustained remission was 22.5 months (95% CI 17.1–26.8). New areas of vessel involvement were observed in 13 patients. Disease progression was arrested in majority (n= 20) with aggressive medical management and endovascular intervention. All 11 patients with an increment in TADS of ≥4 units during follow up had persistently active or relapsing disease. There was single case with fatality.



Conclusion:

Corticosteroids and immunosuppressive therapy were effective in the control of disease activity. Progression of damage was associated with persistent inflammation. Continued surveillance by clinical instruments and imaging is warranted.
Complement activation during cardiopulmonary bypass: quantitative study of effects of methylprednisolone and pulsatile flow.
Authors: M J Boscoe, V M Yewdall, M A Thompson, J S Cameron
Journal: BMJ (1983)

Forty four patients undergoing open heart surgery were divided into three groups. Group 1 (17 patients) underwent routine anaesthesia and surgery; group 2 (17 patients) received two doses of methylprednisolone (30 mg/kg), one during induction of anaesthesia and the other immediately before induction of cardiopulmonary bypass; and group 3 (10 patients) received pulsatile flow while undergoing pulsatile perfusion by the heart-lung machine. A modification of the previously described technique was used to detect and measure complement activation in plasma before and during the bypass period using crossed immunoelectrophoresis. About 45% of all patients showed measurable complement activation (greater than 4.5%) during cardiopulmonary bypass and the mean activation in this group was 6.4%. There was no significant difference between the three groups in complement activation. In group 2, however, women showed significantly more complement activation than men (p less than 0.05). It is suggested that neither corticosteroids nor pulsatile flow affect complement activation, but caution should be exercised in women receiving methylprednisolone.
Children in Medical Research: Access Versus Protection
Authors: Robert M. Veatch
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The functional effects of modal versus amodal filling-in
Authors: Greg Davis, Jon Driver
Journal: Behavioral and Brain Sciences (1998)

Comparisons between modally and amodally completed regions show that perceptual filling-in is not merely the ignoring of absences. Illusory filled-in colour arises for modal completion, but not for amodal completion in comparable displays. We find that attention spreads automatically to modally but not amodally completed regions from their inducers, revealing a functional effect of filled-in colour.
The Autonomic Nervous System: Morphological, Comparative, Clinical and Surgical Aspects
Authors: Robert E. McMasters
Journal: JAMA (1970)

According to the publisher, this book represents the culmination of 25 years of study and original investigation by the author; indeed, it contains an enormous amount of varied, well-annotated data which undoubtedly will serve as a standard reference for many years to come. Unfortunately, there is little reference to newer physiologic and pharmacologic concepts which are of such great significance and importance to the modern clinician, for the book is constructed upon strong anatomic foundations and will appeal primarily to the student of autonomic anatomy and to the surgeon. A relatively current bibliography, following each of the 28 chapters, and the numerous, superb illustrations, many in color, stand as the outstanding features of the book. The chapters are grouped into four major subdivisions which begin with a splendid historical section, followed by a discussion of the principles of autonomic function based primarily upon older anatomic concepts of classification. Of particular
Selective activation of gamma/delta + T cell clones by single anti-CD2 antibodies.
Authors: S Wesselborg, O Janssen, K Pechhold, D Kabelitz
Journal: The Journal of Experimental Medicine (1991)

The CD2 antigen is the target for an "alternative" T cell activation pathway. Numerous studies have demonstrated that pairs of monoclonal antibodies (mAbs) directed toward two different epitopes are required for activation of T cell receptor (TCR)-alpha/beta + T cells via CD2. We have now explored the activation of human TCR-gamma/delta + T cell clones by a panel of anti-CD2 mAbs directed against the sheep erythrocyte-binding (T11.1) epitope of CD2. Seven of seven gamma/delta + clones expressing different molecular forms of the TCR-gamma/delta responded to stimulation by a single anti-CD2 mAb (OKT11, 9E8, BW0110, M-T910) with IL-2 secretion and/or proliferation. Immobilization of anti-CD2 mAbs in microculture plates was essential for activation of gamma/delta + clones, which occurred in the absence of feeder cells. In addition to interleukin 2 (IL-2) production and proliferation, anti-CD2 mAbs also triggered cytotoxic effector activity in gamma/delta + clones as measured against FcR+ P815 target cells. In contrast to gamma/delta + clones (but in line with established data), none of five CD4+ or CD8+ TCR-alpha/beta + clones were activated by any of the tested individual anti-CD2 mAbs. Taken together, our results reveal a striking difference between cloned gamma/delta + and alpha/beta + T cells in that gamma/delta + T cells are selectively activated by a single anti-CD2 (T11.1) mAb, without need for the simultaneous signal of a second anti-CD2 mAb directed against another (T11.2 or T11.3) CD2 epitope.
786. Synthesis of Cationic Biodegradable Polymers for Targeted Gene Delivery to Hepatocytes
Authors: Gregory T. Zugates, Daniel Anderson, Ingrid Lawhorn, Robert Langer
Journal: Molecular Therapy (2005)

Gene delivery is the introduction of new genetic information into cells to achieve a therapeutic effect. It is envisioned that this form of therapy may be useful in treating cancer, infectious diseases, neurodegenerative illnesses, and vascular diseases to name a few. Before this can become a reality, a system needs to be developed for the safe, selective delivery of the gene to the cell population of interest with high efficiency. Viruses have been largely explored for this purpose but problems with safety and immunogenicity have yet to be resolved. Non-viral vectors, such as lipids and cationic polymers, have been studied as alternatives but still suffer from low transfection efficiencies, especially in non-dividing cells. Recent studies with poly(b-amino ester)s have shown them to be promising materials for gene delivery. These cationic, degradable polymers associate with plasmid DNA through electrostatic interactions to form nanoparticles that can be readily endocytosed by cells. In a recent study, a combinatorial approach was used to synthesize a large library of poly(b-amino ester)s and test them for gene delivery on fibroblast cell cultures. Forty-six polymers were found to deliver DNA as good as or better than polyethylenimine, the best commercially available polymer. The best polymer found, designated as C32, and many others in the library that are highly effective consist of hydrophobic backbones and side chains containing a primary alcohol.
Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis
Authors: H SULIMAN, K WELTYWOLF, M CARRAWAY, L TATRO, C PIANTADOSI
Journal: Cardiovascular Research (2004)

Objective: The responses to bacterial lipopolysaccharide (LPS) damage mitochondria by generating oxidative stress within the organelles. We postulated that LPS damages heart mitochondrial DNA and protein by oxidation, and that this is recovered by oxidative mechanisms of mitochondrial biogenesis.
Regulation of CD1 Function and NK1.1+ T Cell Selection and Maturation by Cathepsin S
Authors: Richard J. Riese, Guo-Ping Shi, Jose Villadangos, Daniel Stetson, Christoph Driessen, Ana-Maria Lennon-Dumenil, Ching-Liang Chu, Yuri Naumov, Samuel M. Behar, Hidde Ploegh, Richard Locksley, Harold A. Chapman
Journal: Immunity (2001)
Naming of drugs.
Authors: M H Ball
Journal: BMJ (1979)

adrenaline, or MA plus NMA are due to a chemical rather than to a metabolic effect of labetalol and represent falsely high values.Adequate methods should be employed in future studies evaluating the effects of labetalol on the sympathetic nervous system.Further- more, our findings may prevent errors in the differential diagnosis of phaeochromocytoma.
ELISA method for detection of mite allergens in barn dust: comparison with mite counts
Authors: B. Härfast, E. Johansson, S. G. O. Johansson, M. van Hage‐Hamsten
Journal: Allergy (1996)

ELISA (enzyme-linked immunosorbent assay) inhibition with a monoclonal antibody (mAb) (42B6) to Lepidoglyphus destructor was used to detect and quantify the storage-mite allergens in 30 dust samples collected from barns. Regarding the mite fauna, microscopic inspection of the barn dust and mite counts showed that L. destructor infested all 30 barns investigated (range 430-195 400 mites/g dust). In 29/30 barns, L. destructor constituted more than 70% of the Astigmata species. Acarus siro was found in 26 samples, the highest value being 16155 mites/g. No Dermatophagoides species were found. As to mites of the suborder of Prostigmata, species belonging to seven different families were detected. Besides the predominant L. destructor, allergens derived from other storage mites such as Glycyphagus domesticus, A. siro, and Tyrophagus putrescentiae have previously been assessed by this ELISA method. The correlation between number of mites and concentrations of mite antigen as measured by ELISA was assessed by linear regression (r2 = 0.83). Thus, inhibition of mAb 42B6 in ELISA would seem to offer a simple and reliable method to detect levels of dust-mite species belonging to the Acaridae and Glycyphagidae families.
Determination of Systolic Thickening Index With Gated Tc-99m Sestamibi SPECT
Authors: ANNE-SOPHIE HAMBŸE, ANDRÉ DOBBELEIR, MARC DERVEAUX, JOHAN VANDEVIVERE, PAUL VAN DEN HEUVEL
Journal: Clinical Nuclear Medicine (1997)

Myocardial perfusion imaging with Tc-99m MIBI SPECT may underestimate the amount of viable myocardium in patients with coronary artery disease and prior infarction. Electrocardiogram gating could potentially better correlate with the presence of jeopardized myocardium, since it allows the evaluation of systolic contractility parameters in addition to the assessment of perfusion. Using the diastolic and systolic bull's eyes of a rest Tc-99m MIBI-gated SPECT study to generate an index of systolic thickening, we clearly observed an impaired contractility in the anterior and septal walls in a patient with multiple vessel disease and a mild mid-left anterior descending stenosis, despite a normal tracer uptake. Confirmation of the index of systolic thickening findings was obtained by rest/redistribution TI-201 SPECT, showing decreased anteroseptal perfusion on the early images with almost complete perfusion. Gating myocardial perfusion imaging seems helpful to identify myocardium at risk. It can aid in the evaluation of the physiological significance of mild coronary artery disease, sometimes insufficient to result in perceptible flow disturbances but already responsible for contractility abnormalities, especially when a large arterial territory is involved.
THE RECRUITMENT OF SYSTEMIC TO PULMONARY COLLATERALS IN CHRONIC AND SEVERE PULMONARY HYPERTENSION AS AN ADAPTIVE MECHANISM: DO WE TREAT THESE COLLATERALS IN REALITY?
Authors: Cihangir Kaymaz, Zulal Uslu, Necla Kirca, Tugba Aktemur, Nertila Poci, Selcuk Ozturk, Ozgur Y. Akbal, Fatih Yilmaz, Hacer Ceren Tokgoz, Tahsin Guneysu, Nihal Ozdemir
Journal: Journal of the American College of Cardiology (2014)
Remission of Diabetes by Insulin Gene Therapy Using a Hepatocyte-specific and Glucose-responsive Synthetic Promoter
Authors: Jaeseok Han, Brienne McLane, Eung-Hwi Kim, Ji-Won Yoon, Hee-Sook Jun
Journal: Molecular Therapy (2010)

Efficient production of insulin in response to changes in glucose levels has been a major issue for insulin gene therapy to treat diabetes. To express target genes in response to glucose specifically in hepatocytes, we generated a synthetic promoter library containing hepatocyte nuclear factor-1, CAAT/enhancer-binding protein (C/EBP) response element, and glucose-response element. Combinations of these three cis-elements in 3-, 6-, or 9-element configurations were screened for transcriptional activity and then glucose responsiveness in vitro. The most effective promoter (SP23137) was selected for further study. Intravenous administration of a recombinant adenovirus expressing furin-cleavable rat insulin under control of the SP23137 promoter into streptozotocin (STZ)-induced diabetic mice resulted in normoglycemia, which was maintained for >30 days. Glucose tolerance tests showed that treated mice produced insulin in response to glucose and cleared exogenous glucose from the blood in a manner similar to nondiabetic control mice, although the clearance was somewhat delayed. Insulin expression was seen specifically in the liver and not in other organs. These observations indicate the potential of this synthetic, artificial promoter to regulate glucose-responsive insulin production and remit hyperglycemia, thus providing a new method of liver-directed insulin gene therapy for type 1 diabetes.
Computed Tomography to Evaluate Chronic Sinusitis
Authors: Berrylin J. Ferguson
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Dr Newman and colleagues<sup>1</sup>in their article on chronic sinusitis attempt to design a scoring system for extent of disease by computed tomographic (CT) scan. I have several questions regarding the scoring system. First, a scan can receive of maximum of 3 points for soft-tissue thickening of the nasal passages. How does one score a nose that is completely obstructed on one side, but clear on the other? Would that be 1.5 points? Although it is helpful to have a quantitative measure of sinus disease by CT, it is important to remember that mucosal thickening noted on sinus CT can be transient and associated with viral illness. It is not mentioned in the article whether the patients were on maximal medical therapy at the time of the CT scan or whether the patients were having baseline symptoms or an exacerbation of their symptoms. Phillips<sup>2</sup>recently
Points: General versus spinal anaesthesia
Authors: J P Alexander
Journal: BMJ (1985)

authors in proposing trials of adjunctive chemo- therapy after radical hysterectomy in patients at risk of recurrence but must emphasise that the reported efficacy of drug combinations applies only at present to squamous disease.Alberts et al, using cisplatin, vincristine, mito- mycin, and bleomycin showed significant long term responsiveness of recurrent and metastatic squamous cell carcinoma of the cervix.'Personal experience in their department (AC) and in Ireland using this combination, particularly in unirradiated tissues, confirms these and other reported response rates.A prospective randomised clinical trial is under way under the auspices of the Irish Gynaecological Oncology Group using this combination after radical hysterectomy for stage lb squamous carcinoma of the cervix with associated risk factors for recurrence.This brings us to suggest the hitherto-unthink- able.Given those at high risk of residual disease after radical hysterectomy and the increasingly effective chemotherapy regimens, how do we assess the status of the patient after adjunctive chemotherapy?Are we approaching the concept of secondary exploratory laparotomy subsequent to postoperative chemotherapy for squamous cell carcinoma of the cervix?
Increased Airways Hyperresponsiveness and Inflammation in Influenza-Induced Murine Model of Asthma
Authors: Eu Kyoung Lee, Sulmui Won, Ji Hoon Kim, Hwan Soo Kim, Yoon Hong Chun, Jong-seo Yoon, Hyun Hee Kim, Jin-Tack Kim
Journal: Journal of Allergy and Clinical Immunology (2015)
Skin Ulcers Due to Tertiary Syphilis
Authors: J. J. Robbins, Everett P. Kirch
Journal: New England Journal of Medicine (1959)

THE recent literature contains warnings of dangers inherent in the prevalent belief that the problem of syphilis has already been solved.1 , 2 Authorities in the field3 4 5 point out, especially in view of the passing of the diagnosis and management of syphilis from the hands of the specialist, that there is need for constant awareness of the protean manifestations of this disease. This is essential if outbreaks of syphilitic infections are to be prevented from becoming epidemic. The case of skin lesions due to tertiary syphilis reported below illustrates an interesting variation in the natural course of this disease. The fact that . . .
Implanted Electroenzymatic Glucose Sensors
Authors: Leland C Clark, Carol A Duggan
Journal: Diabetes Care (1982)

The advent of electrochemical sensors for intermittent sampling of blood gases and hydrogen ions in the clinic, intensive care, and surgical units has revolutionized diagnostic and critical care medical technics. The use of electrochemical sensors for continuous transcutaneous monitoring of blood gases is further enhancing the medical surveillance of patients. The more recent introduction of glucose and other electroenzymatic sensors has stimulated broad research in the development of metabolic monitoring. For the present research, the glucose sensor widely used for the rapid specific micro-analysis of whole blood and plasma is explored for possible use as an in vivo intravascular or tissue-implanted sensor. This sensor is based on the polarographic measurement of hydrogen peroxide generated by glucose oxidase (EC 1.1.3.4) held between two membranes. The first membrane allows the diffusion of glucose, ions, and many other small molecules, while the second membrane allows the diffusion of the glucose-generated hydrogen peroxide to the platinum surface, but excludes ascorbic acid, bilirubin, and uric acid. Such sensors respond rapidly and specifically when acutely implanted subcutaneously in cats and dogs. They function well as glucose-sensor-tipped venous catheters. One sensor was repeatedly used for in vitro polarograms, subcutaneous and blood glucose monitoring, over a period of ten months, with storage in the cold between uses, with the complete retention of its response characteristics.
Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma
Authors: Jose R. Cortes, Maria D. Rivas, Javier Molina-Infante, Maria A. Gonzalez-Nuñez, Moises Perez-G, Juan F. Masa, Juan F. Sanchez, Jose Zamorano
Journal: Journal of Allergy and Clinical Immunology (2009)
Chronic Subdural Hematoma of the Spinal Cord
Authors: J. Paul Rader
Journal: New England Journal of Medicine (1955)

ALTHOUGH intracranial chronic subdural hematoma is a well recognized and documented clinical entity, the occurrence of such a lesion in a spinal location has not heretofore been reported to my knowledge. The following case is presented as an example of such an occurrence.Case ReportA 40-year-old oilfield mechanic was admitted to the Medical Center Hospital on February 14, 1955, with a chief complaint of progressive weakness of the right leg of 5 years' duration.He gave a history of having been injured on February 28, 1950, while working under the floor of an oil derrick that was 5 feet . . .