tbuckley/cabot-search huggingface dataset:
Predicting posttransplantation diabetes mellitus by regulatory T-cell phenotype: implications for metabolic intervention to modulate alloreactivity
Authors: Brian G. Engelhardt, Shubhada M. Jagasia, James E. Crowe, Michelle L. Griffith, Bipin N. Savani, Adetola A. Kassim, Pengcheng Lu, Jörn-Hendrik Weitkamp, Daniel J. Moore, Sandra M. Yoder, Michael T. Rock, Madan Jagasia
Journal: Blood (2012)
Regional blood flows in unanaesthetized rhesus monkeys during myocardial infarction
Authors: J. D. HILL, M. H. LEES, M. R. MALINOW, A. J. OCHSNER, C. THOMAS
Journal: Cardiovascular Research (1973)

After acute myocardial infarction in rhesus monkeys, the decreased cardiac output was redistributed so that the brain, heart, liver, and adrenals received a relative increase in the fractional distribution at the expense of a decrease to the remaining parts of the body.
A Christmas lecture
Authors: James Owen Drife
Journal: BMJ (2011)

In my first interview for an academic post they asked me why I wanted to be a university lecturer. I said something like, “Well, I like lecturing,” and quickly realised it was the wrong answer. Nobody trusts a smart alec, especially one who enjoys public speaking.⇑

At least my reply was honest, though nowadays that may be hard to believe. Back in the 1970s all you needed for a talk was a set of multicoloured felt tip …
Zinc oxide increases degradation of collagen in necrotic wound tissue
Authors: M.S. Agren
Journal: British Journal of Dermatology (1993)

Journal Article Zinc oxide increases degradation of collagen in necrotic wound tissue Get access M.S. ÅGren M.S. ÅGren Department of Pathology, Faculty of Health Sciences, Linköping, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 129, Issue 2, 1 August 1993, Pages 221–222, https://doi.org/10.1111/j.1365-2133.1993.tb03533.x Published: 01 August 1993
Regulation of p38 Phosphorylation and Topoisomerase IIα Expression in the B-Cell Lymphoma Line Jiyoye by CD26/Dipeptidyl Peptidase IV Is Associated with Enhanced<i>In vitro</i>and<i>In vivo</i>Sensitivity to Doxorubicin
Authors: Toshiko Yamochi, Tadanori Yamochi, Ugur Aytac, Tsutomu Sato, Kazuya Sato, Kei Ohnuma, Kathryn S. McKee, Chikao Morimoto, Nam H. Dang
Journal: Cancer Research (2005)

Abstract CD26 is a Mr 110,000 surface-bound glycoprotein with diverse functional properties, including having a key role in normal T-cell physiology and the development of certain cancers. In this article, we show that surface expression of CD26, especially its intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity, results in enhanced topoisomerase IIα level in the B-cell line Jiyoye and subsequent in vitro sensitivity to doxorubicin-induced apoptosis. In addition, we show that expression of CD26/DPPIV is associated with increased phosphorylation of p38 and its upstream regulators mitogen-activated protein kinase kinase 3/6 and apoptosis signal-regulating kinase 1 and that p38 signaling pathway plays a role in the regulation of topoisomerase IIα expression. Besides demonstrating that CD26 effect on topoisomerase IIα and doxorubicin sensitivity is applicable to cell lines of both B-cell and T-cell lineages, the potential clinical implication of our work lies with the fact that we now show for the first time that our in vitro results can be extended to a severe combined immunodeficient mouse model. Our findings that CD26 expression can be an in vivo marker of tumor sensitivity to doxorubicin treatment may lead to future treatment strategies targeting CD26/DPPIV for selected human cancers in the clinical setting. Our article thus characterizes the biochemical linkage among CD26, p38, and topoisomerase IIα while providing evidence that CD26-associated topoisomerase IIα expression results in greater in vitro and in vivo tumor sensitivity to the antineoplastic agent doxorubicin.
Tetanus Immune Globulin
Authors: Morton A. Madoff
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In his LETTER TO THE EDITOR (225:179, 1973), Dr. Milton H. Stern points to the recommendations indicating the use of tetanus immune globulin (human) in individuals not previously immunized against tetanus. An editorial reply states that "Tetanus immune globulin is not always readily available...." Dr. Stern's position is the more appropriate. Tetanus immune globulin is in adequate supply in the United States, at reasonable cost. It should be as available to physicians as is any other emergency medication that they might expect to use. Justification for the use of equine tetanus antitoxin must be rare, indeed, in the United States at the present.
Local Therapy with Continued EGFR Tyrosine Kinase Inhibitor Therapy as a Treatment Strategy in EGFR-Mutant Advanced Lung Cancers That Have Developed Acquired Resistance to EGFR Tyrosine Kinase Inhibitors
Authors: Helena A. Yu, Camelia S. Sima, James Huang, Stephen B. Solomon, Andreas Rimner, Paul Paik, M. Catherine Pietanza, Christopher G. Azzoli, Naiyer A. Rizvi, Lee M. Krug, Vincent A. Miller, Mark G. Kris, Gregory J. Riely
Journal: Journal of Thoracic Oncology (2013)
Tongue Necrosis: An Unusual Clinical Presentation of Giant Cell Arteritis
Authors: Alejandro Lobato‐Berezo, María Alcalde‐Villar, Adrián Imbernón‐Moya, Marcela Martínez‐Pérez, Antonio Aguilar‐Martínez, Paz Collado‐Ramos
Journal: Arthritis & Rheumatology (2014)
Restore ward rounds to former glory to improve patient care, say colleges
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Doctors’ and nurses’ leaders have called for ward rounds to be restored to the position they once held as the cornerstone of hospital care and for a “concerted culture change” to enable clinicians and mangers to work together to improve quality.

In a joint statement the Royal College of Physicians and the Royal College of Nursing said that ward rounds were often neglected during the planning and organisation of patient care.1 How and why hospitals conducted ward rounds was variable, and their value to patients and the whole …
Improvements in quality of clinical care in English general practice 1998-2003: longitudinal observational study
Authors: Stephen M Campbell, Martin O Roland, Elizabeth Middleton, David Reeves
Journal: BMJ (2005)

<h3>Abstract</h3> <b>Objective</b> To measure changes in quality of care for three major chronic diseases (coronary heart disease, asthma, and type 2 diabetes) between 1998 and 2003. <b>Design</b> Longitudinal cohort study. <b>Setting</b> 42 general practices in six geographical areas of England (Avon, Bury/Rochdale, Enfield, Oldham, Somerset, South Essex). <b>Participants</b> Medical record data for 2300 patients with diabetes, asthma, or coronary heart disease in 1998, and 1495 patients in 2003. <b>Main outcome measure</b> Quality of care assessed against predefined evidence based review criteria. <b>Results</b> Between 1998 and 2003, quality of care improved markedly in terms of maximum possible scores on the review criteria, from 60.5% to 78.1% for coronary heart disease (change = 17.6, 95% confidence interval 13.9 to 21.4; P &lt; 0.001), 60.1% to 70.3% for asthma (10.2, 4.6 to 15.8; P = 0.001), and 70.4% to 77.7% for diabetes (7.3, 3.5 to 11.1; P = 0.001). Important changes occurred to several indicators potentially related to improved health outcomes. These included improved control of serum cholesterol (to ≤ 5 mmol/l) from 17.6% to 61.4% in coronary heart disease and from 21.5% to 52% in diabetes and control of blood pressure to ≤150/90 in coronary heart disease from 47.3% to 72.2% and to ≤145/85 in diabetes from 21.8% to 35.8%. A small, non-significant improvement in glycaemic control occurred among diabetic patients (37.9% to 39.7% with HbA<sub>1c</sub> &lt; 7.4%). Significant improvements also occurred in the recording of exercise capacity and diet and weight advice for patients with coronary heart disease; of smoking advice, peak flow, and symptoms for patients with asthma; and of creatinine, weight, and HbA<sub>1c</sub> for patients with diabetes. Over the five years, more improvement in coronary heart disease care occurred in large practices and practices in affluent areas. <b>Conclusions</b> Substantial improvements were seen in quality of care for the three conditions studied between 1998 and 2003, a time of systematic quality improvement initiatives in the NHS. The changes were most marked for coronary heart disease. English general practices could be expected to achieve high clinical quality scores in the initial year of a new contact, which provides financial incentives for high quality care from 2004.
Thyroid Hormones and Asthma
Authors: Michael S. Rowe
Journal: Annals of Internal Medicine (1991)

Letters1 January 1991Thyroid Hormones and AsthmaMichael S. Rowe, MDMichael S. Rowe, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-1-97_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: I found the recent article on the monitoring of therapy in patients taking levothyroxine to have significant practical merit (1). The authors state that a full dose of levothyroxine can be given to younger patients although older patients and those with heart disease should be started more slowly. I believe that it should also be noted that patients with asthma should be started more slowly.In my experience, as well as that of others, there seems to be a relation between the thyroid state and the severity of asthma (2, 3). Hypothyroidism seems to improve the clinical...References1. HelfandCrapo ML. Monitoring therapy in patients taking levothyroxine. Ann Intern Med. 1990;113:450-4. LinkGoogle Scholar2. RoweMacKechnie MH. Hypothyroidism with co-existent asthma: problems in management. South Med J. 1984;77:401-2. CrossrefMedlineGoogle Scholar3. BushEhrlichReed REC. Thyroid disease and asthma. J Allergy Clin Immunol. 1977;59:398-401. CrossrefMedlineGoogle Scholar4. Thyroid disease and asthma [Editorial]. BMJ. 1977;2:1173-4. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 24230 Karim Boulevard, Suite 130 Novi, MI 48050 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAssociation between anti-thyroid peroxidase and anti-cytokeratin 18 autoantibodies and bronchial asthma in womenThe coexistence of thyroid autoimmunity in children and adolescents with various allergic diseases 1 January 1991Volume 114, Issue 1Page: 97-97KeywordsAsthmaCardiovascular therapyHypothyroidismThyroidThyroid hormonesThyroxine Issue Published: 1 January 1991 PDF DownloadLoading ...
Diagnostic Accuracy of Early Radiology in Acute Gastrointestinal Haemorrhage
Authors: R. N. Allan, P. W. Dykes, D. K. M. Toye
Journal: BMJ (1972)

The accuracy of early radiology in patients with acute gastrointestinal haemorrhage has been studied by a comparison of the radiological opinion with the established diagnosis. A full examination has proved safe and uncomplicated with a high degree of accuracy and no false-positive results.Analysis of the errors shows that the presence of residue discourages the radiologist from making the correct diagnosis, and modification of the standard bariummeal technique may be needed to overcome this difficulty.
A8.4 Fc-Glycosylation Determines Osteoclastogenic Activity of Immune Complexes
Authors: U Harre, R Pfeifle, A Lux, S Frühbeißer, F Gröhn, G Krönke, F Nimmerjahn, M Herrmann, G Schett
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background and Objectives</h3> Autoantibodies recognising citrullinated proteins (ACPA) are highly specific for rheumatoid arthritis (RA), precede the clinical onset of the disease by years and are the strongest known risk factor for bone loss. We have recently shown that ACPA specific for citrullinated vimentin directly interact with osteoclast precursors and induce bone loss. In patients with RA, ACPA-containing immune complexes can be detected in synovial fluid and tissue. We hypothesised that (I) immune complexes directly promote osteoclast maturation and, consecutively, bone loss and that (II) the type of IgG-glycan is important for the interaction with osteoclast precursors, since ACPA have been shown to be hyposialylated. <h3>Materials and Methods</h3> We differentiated preosteoclasts from human monocytes and stimulated them with artificial immune complexes generated by heat aggregation from pooled human IgG (IVIG). Part of the IgG had been pretreated with neuraminidase or PNGase F to remove sialic acid or the whole Fc glycan, respectively. For in vivo studies we injected murine immune complexes in the knee joints of C57-BL/6 mice. <h3>Results</h3> Stimulation of preosteoclasts with immune complexes resulted in their dramatically increased maturation to osteoclasts. This effect was even more pronounced with complexes formed from desialylated IgG. Monomeric IgG and fully deglycosylated immune complexes did not alter osteoclast maturation. qPCR and FACS-analyses revealed that all Fcγ receptors (FcγR) are upregulated during osteoclastogenesis with FcγR I and FcγR III being the most prominent ones. Desialylated immune complexes induced the activation of spleen tyrosine kinase (Syk) and phospholipase Cγ (PLCγ) as well as the upregulation of the transcription factor c-fos in preosteoclasts. Injection of murine immune complexes into the knee joints of C57-BL/6 mice caused accumulation of osteoclasts in the vicinity of the site of injection. <h3>Conclusions</h3> Our data show that IgG immune complexes promote osteoclastogenesis. They upregulate the pro-osteoclastogenic transcription factor c-fos, after binding to activating FcγRs on preosteoclasts. This interaction is highly dependent on the absence of sialic acid in the Fc-glycan of the IgG. Altogether, we propose a novel mechanism by which ACPA promote bone loss independent of inflammation.
Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension.
Authors: S B Eysmann, H I Palevsky, N Reichek, K Hackney, P S Douglas
Journal: Circulation (1989)

To determine correlates of survival in primary pulmonary hypertension, we compared 41 echocardiography-Doppler and nine catheterization parameters with outcome in 26 patients. Mean follow-up was 19.7 months in survivors; mean survival was 4.8 months in 16 nonsurvivors. Cox life-table univariate analysis correlated two echocardiographic, three Doppler, and three catheterization variables with poor survival (p less than or equal to 0.05), and chi 2 analysis ensured the best critical values: severity of pericardial effusion, heart rate of more than 87 beats/min, pulmonic flow acceleration time of less than 62 msec, tricuspid early flow deceleration (T-DEC) equal to or less than -300 cm2/sec, mitral early flow-to-atrial flow velocity ratio (M-E/A) equal to or less than 1.0, catheterization cardiac index (CI) equal to or less than 2.3 l/min/m2, mean pulmonary artery pressure of more than 61 mm Hg, and diastolic pulmonary artery pressure of more than 43 mm Hg. Multivariate life-table analysis of noninvasive variables revealed the severity of pericardial effusion to be independently significant (p = 0.006), whereas analysis of catheterization variables revealed cardiac index to be independently significant (p = 0.014). Combined multivariate analysis did not differ from the noninvasive results alone. Categorical modeling of the eight significant variables split at their critical values (present or absent) revealed M-E/A, T-DEC, and CI to be independently significant by multivariate analysis (p = 0.0014). Analysis of the five echocardiography-Doppler variables alone revealed M-E/A, T-DEC, and heart rate to be independently significant (p = 0.0016). In both cases, mortality increased with the number of critical values reached.(ABSTRACT TRUNCATED AT 250 WORDS)
Difficulties in the Diagnosis of Congenital Abnormalities
Authors: Frank R. Lock
Journal: JAMA (1961)

Study of 176 children for abnormalities following infection with or exposure to rubella during gestation confirmed an earlier report that certain abnormalities cannot be recognized in early infancy. Some peculiarities at first thought abnormal were later proved to be normal. The first examination at 4 to 12 months of age revealed 32 definite and 27 questionable abnormalities in 35 of the 176 children. On the second examination at 16 to 25 months, only 7 of the questionable abnormalities proved to be significant, but 12 previously unsuspected serious abnormalities were found. In the absence of reliable diagnostic criteria for children less than one year of age, data on the frequency of congenital defects must be interpreted with caution.
Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.
Authors: L Linder, W Kiowski, F R Bühler, T F Lüscher
Journal: Circulation (1990)

In isolated blood vessels, acetylcholine releases endothelium-derived relaxing factor (EDRF). In vivo, the vasodilator action of acetylcholine may be mediated by EDRF, but prostacyclin or prejunctional inhibition of adrenergic neurotransmission may also be involved. Therefore, we investigated whether acetylcholine releases EDRF in humans in vivo and, if so, whether the response altered in essential hypertension. Acetylcholine was infused into the brachial artery, and forearm blood flow measured by venous occlusion plethysmography. In control subjects, acetylcholine (0.02-16 micrograms/min/100 ml tissue) increased flow from 2.4 +/- 5.0 to 20.6 +/- 5.2 ml/min/100 ml tissue (n = 14; p less than 0.05) and decreased forearm vascular resistance from 42.0 +/- 4.1 to 6.0 +/- 1.4 units (p less than 0.03), a response comparable to that of sodium nitroprusside (0.6 micrograms/min ml tissue). Acetylsalicylic acid (500 mg i.v.) given to block vascular prostacyclin production did not alter the response (n = 14). alpha-Adrenoceptor blockade by phentolamine (12 micrograms/min/100 ml tissue) did not prevent the increase in flow evoked by acetylcholine. In hypertensive patients, the decrease in forearm vascular resistance induced by acetylcholine but not evoked by sodium nitroprusside was reduced as compared with controls (14.5 +/- 3.1 and 6.1 +/- 1.6 units, respectively; n = 8; p less than 0.05). Thus, the vascular effects of acetylcholine in the human forearm circulation are independent of prostaglandins and adrenergic neurotransmission and therefore are most likely to be mediated by EDRF; the acetylcholine-induced release of EDRF is blunted in patients with essential hypertension.
Transient Entrainment of Bundle-Branch Reentry by Atrial and Ventricular Stimulation
Authors: Jose L. Merino, Rafael Peinado, Ignacio Fernández-Lozano, Nicolas Sobrino, Jose A. Sobrino
Journal: Circulation (1999)

Background —Different responses to entrainment have been reported in relation to the pacing site of a variety of tachycardias. However, transient entrainment of bundle-branch reentrant tachycardia (BBRT) has not been investigated systematically. Methods and Results —We attempted entrainment of 13 BBRTs in 9 patients by pacing first the right ventricle and then the right atrium. The initial pacing cycle length (CL) was 10 ms faster than the tachycardia CL. Subsequent pacing sequences were performed with 5- to 10-ms CL decrements until tachycardia termination or loss of postatropine 1:1 AV conduction. Both full ventricular-paced and AV-conducted QRS complex references were obtained during sinus rhythm pacing from the same sites and with similar CL as during entrainment. Transient entrainment was achieved by ventricular and atrial stimulation in 11 and 8 tachycardias, respectively. Constant fusion was always present during entrainment by ventricular stimulation. There was no change in the QRS complex (orthodromically concealed fusion) during entrainment by atrial stimulation in 6 of 6 tachycardias with left bundle-branch block morphology and in 1 of 2 tachycardias with right bundle-branch block morphology. Conclusions —BBRT, especially if it has a left bundle-branch block morphology, can be differentiated from other wide-QRS-complex tachycardia mechanisms through analysis of the ECGs recorded during tachycardia entrainment by atrial and ventricular stimulation. This diagnostic approach may be especially useful when it is difficult to record a stable or sufficiently sized His bundle electrogram or when spontaneous changes in the ventricular CL precede similar changes in the His bundle CL.
Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns
Authors: Anna Schuh, Jennifer Becq, Sean Humphray, Adrian Alexa, Adam Burns, Ruth Clifford, Stephan M. Feller, Russell Grocock, Shirley Henderson, Irina Khrebtukova, Zoya Kingsbury, Shujun Luo, David McBride, Lisa Murray, Toshi Menju, Adele Timbs, Mark Ross, Jenny Taylor, David Bentley
Journal: Blood (2012)
Abstract 5775: A novel role for ID1 in prostate cancer chemotherapy
Authors: Hao Geng, Tomasz Beer, Pete Nelson, David Qian
Journal: Cancer Research (2010)

Abstract To identify potential mechanisms underlying prostate cancer chemotherapy response and resistance, we compared the gene expression profiles in individual human prostate cancer specimens before and after chemotherapy collected from previously untreated patients with high-risk, localized disease. Among the molecular signatures associated with treatment, transcripts encoding Inhibitor of DNA Binding 1 (ID1) were significantly upregulated. Among patients who developed biochemical relapse 5 years after chemo-surgery, patients with the ID1 upregulation following chemotherapy had significantly longer relapse-free survival time than patients without ID1 increases. In the prostate cancer LNCaP cell line that is characterized by low ID1 expression, docetaxel dose-dependently induced ID1 expression. This docetaxel-induced ID1 transcription was mediated by ID1 promoter E-box chromatin modification and c-Myc binding. Compared to the empty-vector control, stable ID1 overexpression in LNCaP increased cell proliferation, promoted cell cycle progression through the G1 phase, and enhanced docetaxel-induced cytotoxicity. These phenotypic changes were accompanied by an increase in BCL2 phosphorylation at serine 70, caspase-3 activation and PARP cleavage. In contrast, ID1 siRNA in the LNCaP and C42B cell line reduced cell proliferation and decreased docetaxel-induced cytotoxicity. The ID1-mediated chemosensitivity enhancement was in part due to the ID1-suppression of p21. Overexpression of p21 in LNCaP-ID1 overexpressing cells restored the p21 level and reversed ID1-enhanced chemosensitivity. These data demonstrate that ID1 has a novel therapeutic role in prostate cancer treatment and ID1 upregulation after chemotherapy exposure may be a useful marker of chemotherapy efficacy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5775.
Cutting Europe's meat and dairy consumption would benefit health and environment, says report
Authors: N. Hawkes
Journal: BMJ (2014)

If Europeans cut their meat and dairy consumption by 50% it would help their health and the environment, a new report has said.

It said that nitrogen pollution in air and water would reduce, greenhouse emissions would decrease by more than 40%, and large areas of farmland would be made available for producing food for export or crops for bioenergy. In addition, saturated fats in diets would fall by 40% without reducing protein intake to below the recommended daily level.

The figures came from …