tbuckley/cabot-search huggingface dataset:
Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor.
Authors: B Seetharam, E I Christensen, S K Moestrup, T G Hammond, P J Verroust
Journal: Journal of Clinical Investigation (1997)

Previous studies in the rat have shown that antibodies to gp280, a protein > 200 kD and closely associated with the early endocytic system can induce fetal malformations. Although gp280 is thought to act as a receptor, its ligand(s) is not known. In the current study, we report that purified gp280 from rat kidney, like the intrinsic factor-Cobalamin receptor (IFCR), binds to the intrinsic factor-cobalamin (IFCbl) complex with an association constant of 0.3 x 10(9) M-1 and mediates its internalization. Furthermore, antibodies raised to purified gp280 and IFCR inhibited the binding of IF-[57Co]Cbl complex to intestinal, renal, and yolk sac apical membranes and revealed a single identically sized protein on immunoblotting of the renal membranes. Both antibodies precipitated a single radiolabeled protein > 200 kD from cellular extract from [35S]methionine-labeled yolk sac epithelial cells, and antibody to gp280 inhibited the uptake and internalization of 125IF-Cbl. Immunoelectron microscopy using the two antibodies revealed that in the kidney, both proteins were colocalized. These observations suggest that IF-Cbl complex is a ligand for gp280 and that gp280 and IFCR are identical proteins.
Participating in Biomedical Research
Authors: Tia Powell, Bruce D. Rapkin, Elisa S. Weiss
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene expression profile of CD8 T cells from the responder and non-responder mice following immunotherapy treatment for prostate cancer
Authors: Seema Dubey, Sumedha Gunewardena, Peter Van Veldhuizen, J Thrasher, Dev Karan
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Immunotherapy represents a novel treatment approach for cancer; however, a longer maturation time and the lack of immunological markers are major obstacles in the development and characterization of immunological therapies. This study aims to identify gene expression profile on
Tight Glycemic Control versus Standard Care after Pediatric Cardiac Surgery
Authors: Michael S.D. Agus, Garry M. Steil, David Wypij, John M. Costello, Peter C. Laussen, Monica Langer, Jamin L. Alexander, Lisa A. Scoppettuolo, Frank A. Pigula, John R. Charpie, Richard G. Ohye, Michael G. Gaies
Journal: New England Journal of Medicine (2012)

In some studies, tight glycemic control with insulin improved outcomes in adults undergoing cardiac surgery, but these benefits are unproven in critically ill children at risk for hyperinsulinemic hypoglycemia. We tested the hypothesis that tight glycemic control reduces morbidity after pediatric cardiac surgery.
A Genome-Wide Association Study of Non-Steroidal Antiinflammatory Drugs (NSAIDs)-Induced Acute Urticaria in the Spanish Population
Authors: Mike T.M. Lee, Jose A. Cornejo-Garcia, Yuan-Tsong Chen, Chien-Hsiun Chen, Natalia Blanca-López, Inmaculada Doña, Maria J. Torres, Carmen Rondon, Paloma Campo, Jose Julio Laguna, F. Javier Fernandez, Pedro Ayuso Parejo, Maria del Carmen Plaza-Serón, Maria Del Mar Gandolfo Cano, Ana Rosado Ingelmo, Gabriela Canto, Miguel Blanca
Journal: Journal of Allergy and Clinical Immunology (2013)
Toward a strategy for demonstrating the perceptual independence of the global array from individual sensory arrays
Authors: Leonard S. Mark
Journal: Behavioral and Brain Sciences (2001)

This commentary discusses a strategy by which investigators can examine whether observers perceive properties of the global array independently of properties in individual sensory arrays. Research showing that perception of complex relationships appears to be independent of the perception of individual components is considered. Ashby and Townsend's (1986) methods for identifying perceptual independence are important tools for studying the global array.
Trends in health care resource use for hepatitis C virus infection in the United States†
Authors: William C. Grant, Ravi R. Jhaveri, John G. McHutchison, Kevin A. Schulman, Teresa L. Kauf
Journal: Hepatology (2005)

Chronic hepatitis C virus (HCV) infection affects approximately 3 million people in the United States and places tremendous demands on the health care system. As many observers have predicted, the disease burden continues to grow as the infected population ages. In this study, we analyzed inpatient data from the Healthcare Cost and Utilization Project, outpatient data from the National Ambulatory Medical Care Survey, and drug data from the Verispan Source Prescription Audit. We examined recent growth in the use of health care resources among HCV patients by age group and found average annual increases of 25% to 30% for hospitalizations, charges, hospital days, and physician visits. Corresponding time-trend coefficients were positive (P < .001). From 1994 to 2001, the HCV burden increased among patients aged 40 to 60 years, reflecting the natural history of disease progression. In sensitivity analysis, HCV outcome growth rates remained significant, unless more than 3 out of 4 cases were initially underreported. Also, patients co-infected with HIV and HCV in 2001 constituted 7.5 times as many hospitalizations and incurred 2.9 times the charges in 1994, relative to all HIV hospitalizations and charges. Our findings highlight the urgency concerning HCV outcomes. In conclusion, as patients continue to age and disease burden progresses, suboptimal decisions regarding HCV treatments will bring increasing opportunity costs for the health care system and society. (HEPATOLOGY 2005;42:1406–1413.)
EXPERIMENTAL AIR EMBOLISM OF THE CORONARY ARTERIES
Authors: GEORGE RUKSTINAT
Journal: JAMA (1931)

In a previous communication1the constant presence of air was noted in the coronary arteries of guinea-pigs dead of air embolism induced by intratracheal insufflation of air. Subsequently it was determined to ascertain the effect of air injected directly into the coronary arteries of dogs. The following technic was used on thirty-five dogs: An incision was made in the left third or fourth intercostal space in its ventral fourth, the adjacent ribs were retracted, and the heart was exposed by a vertical incision in the pericardial sac. Air was introduced into the coronary arteries through a fine needle attached to a syringe. Intratracheal insufflation of ether and artificial respiration were maintained throughout the experiment. Four series of experiments were performed. In the first, air injections were made into the left coronary artery or either or both of its branches. In the second, injections were made into both coronary arteries.
Prevalence of Renovascular Hypertension in Patients with Grade III or IV Hypertensive Retinopathy
Authors: Bruce A. Davis, James E. Crook, Robert E. Vestal, John A. Oates
Journal: New England Journal of Medicine (1979)

STRATEGY for diagnosing renovascular hypertension has been influenced by an estimate that the disorder has a prevalence of 5 per cent or less in the population with hypertension.1 To apply that estimate to an individual patient with hypertension assumes that the prevalence of renovascular hypertension is the same throughout the spectrum of hypertensive severity. To evaluate whether renovascular hypertension has a higher prevalence in patients with very severe hypertension, we investigated the frequency with which renovascular hypertension was detected in patients with malignant (Grade IV hypertensive retinopathy) and accelerated (Grade III hypertensive retinopathy) hypertension.MethodsPatient SelectionRecords of patients . . .
Krüppel-like factor 4 regulates macrophage polarization
Authors: Xudong Liao, Nikunj Sharma, Fehmida Kapadia, Guangjin Zhou, Yuan Lu, Hong Hong, Kaavya Paruchuri, Ganapati H. Mahabeleshwar, Elise Dalmas, Nicolas Venteclef, Chris A. Flask, Julian Kim, Bryan W. Doreian, Kurt Q. Lu, Klaus H. Kaestner, Anne Hamik, Karine Clément, Mukesh K. Jain
Journal: Journal of Clinical Investigation (2011)

Current paradigms suggest that two macrophage subsets, termed M1 and M2, are involved in inflammation and host defense. While the distinct functions of M1 and M2 macrophages have been intensively studied — the former are considered proinflammatory and the latter antiinflammatory — the determinants of their speciation are incompletely understood. Here we report our studies that identify Krüppel-like factor 4 (KLF4) as a critical regulator of macrophage polarization. Macrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human inflammatory paradigms in vivo. Mechanistically, KLF4 was found to cooperate with Stat6 to induce an M2 genetic program and inhibit M1 targets via sequestration of coactivators required for NF-κB activation. KLF4-deficient macrophages demonstrated increased proinflammatory gene expression, enhanced bactericidal activity, and altered metabolism. Furthermore, mice bearing myeloid-specific deletion of KLF4 exhibited delayed wound healing and were predisposed to developing diet-induced obesity, glucose intolerance, and insulin resistance. Collectively, these data identify KLF4 as what we believe to be a novel regulator of macrophage polarization.
Role of free radicals in the pathogenesis of cystic fibrosis.
Authors: R K Brown, F J Kelly
Journal: Thorax (1994)

Role of free radicals in the pathogenesis of cystic fibrosisIn recent years great advances have been made in under-Genetically determined abnormalit standing the underlying genetic defect in cystic fibrosis, mucus secretion and airway electrc but the cause of the severe lung damage and pulmonary bacterial adhesion and impaire fibrosis, which are responsible for most of the deaths, mucociliary clearance remains unclear.The precise link between the cystic fibrosis gene, its biochemical consequences, and the increased susceptibility to pulmonary infection, particu- larly with Pseudomonas aeruginosa, has not been eluci- dated.It has proved to be extremely difficult to determine Bacterial colonisation what constitutes a primary abnormality and what is a secondary consequence of infection.However, irregulari- ties in ion transport leading to inspissation of mucous secretions, along with increased adherence of bacteria to Increased recruitment ofl epithelia and reduced mucociliary clearance, probably all polymorphonuclear °f Bror contribute to the recurrent progressive pulmonary infec- leucocytes to the lungs Bro tion characteristic of the disease (fig 1).The mechanism ne responsible for the damage to the lungs and the agents concerned have, however, been largely ignored in the pursuit of a genetic answer to the disease.The final Hy solution must inevitably have a genetic basis but, as this Free radicals, Pne may not be realised until the turn of the century at the proteases/elastases HaE earliest, investigation of the physiological damage may release Ate prove to be more beneficial to those already suffering from the disease.The role of free radicals in several diseases with pul- monary complications including hyperoxic lung injury in Pulmonary fibrosis and premature infants,' adult respiratory distress syndrome,2 bronchiectasis asthma,3 and the effect of environmental pollutants4 has recently attracted much attention.In all these cases it has been suggested that oxygen free radicals, produced in various ways, are implicated in the damage to the pulmon-Hypoxia and ary epithelium (table 1).Evidence is now accumulating pulmonary hypertension on August 2,
Interprofessional education and teamworking: a view from the education providers
Authors: J. Finch
Journal: BMJ (2000)

Based on a presentation from the Millennium Festival of Medicine 

> There will be new joint training across the professions in communication skills and in NHS principles and organisation. They will form part of a new core curriculum for all education programmes for NHS staff…. A new common foundation programme will be put in place to enable students and staff to switch careers and training paths more easily.1
> 
> We believe it is important that the NHS … should work with higher education providers and accreditation bodies … to develop education and training arrangements which are genuinely multi-professional and which will enable students to transfer readily between courses without having to start their training afresh.2

These bold—and wholly laudable—statements are taken from two major documents published in the year 2000 on the future of the health service. The strength of the statements, and their inclusion within these two important documents, highlights the central role now being accorded to ideas of multiprofessional and inter-professional education in the development of the “new” NHS.

How is this to be delivered? To deliver on these aspirations, the NHS depends wholly on the ability of the education providers—universities and higher education colleges— to comprehend, embrace, and then provide interprofessional training. It is important therefore that education providers are an active part of this debate.

#### Summary points

Universities and colleges are eager to work with the health service but require greater clarity about health service objectives

Different types of education provision are required, depending on which of the four versions of “interprofessional” is being advocated

Learning in clinical as well as classroom settings may hold the key

The first and most obvious point is the need to be clear about objectives; in turn that means being clear about definitions. In the health literature the terms “multiprofessional” and “interprofessional” …
Is influenza A(H1N1) pneumonia more severe than other community-acquired pneumonias? Results of the GiViTI survey of 155 Italian ICUs
Authors: Guido Bertolini, Carlotta Rossi, Daniele Crespi, Stefano Finazzi, Marco Morandotti, Sandra Rossi, Mario Peta, Martin Langer, Daniele Poole
Journal: Intensive Care Medicine (2011)
Predicting outcomes and drug resistance with new standardised treatment
Authors: P.R. Mohapatra, D.T. Hari
Journal: European Respiratory Journal (2011)

Predicting outcomes and drug resistance with new standardised treatmentTo the Editors:In their hypothetical cohorts OXLADE et al. [1] predicted significant public-health benefits by changing from the 8-month to the 6-month (2HRZE/6HE to 2HRZE/4HR; where H5isoniazid, R5rifampicin, Z5pyrazinamide and E5ethambutol) regimen.Data from 2008 on drug-resistance surveillance from five World Health Organization (WHO) regions, i.e.Africa (Botswana), Western Pacific (China), Africa (Mozambique), South-East Asia (Burma) and Europe (Tajikistan), has shown isoniazid resistances among newly diagnosed cases varies from 9.0% to 26.6% and among previously treated cases from 11.7% to 74.4% [2].India and China carry the greatest estimated burden of multidrugresistant (MDR)-tuberculosis (TB), together accounting for almost 50% of the total cases worldwide [2] The incidence of mono-drug resistance among new cases in tuberculosis endemic countries is also high [3].Relapse cases (from all previously mentioned sites) had 5.5 times higher odds of harbouring MDR-TB strains when compared with new cases (95% CI 4.4-6.8),after adjusting for the clustering effect at the country level [2].The WHO has recommended discontinuation of the regimen that doesn't have rifampicin in the continuation phase (to replace HE by HR) [2].Thus, rifampicin should be part of regimen throughout the treatment period; both in the intensive and continuation phase.Again the use of isoniazid and rifampicin in the continuation phase of the 6-month regimen (2HRZE/4HR) could lead to acquired MDR in the areas where the incidence of mono-drug resistance among new cases is high [4].By using HR in the case of mono-resistance to isoniazid, practically only rifampicin is given during continuation phase.Therefore, the third recommendation of the WHO guidelines states: ''In populations with known or suspected high levels of isoniazid resistance, new TB patients may receive HRE as therapy in the continuation phase as an acceptable alternative to HR'' [4].Thus, in areas with higher levels of isoniazid resistance, newly diagnosed TB patients should receive 2HRZE/4HRE instead of 2HRZE/4HR (three-drug regimen in continuation phase) instead of HR or HE.Therefore, it will be more effective if the authors in their hypothetical cohorts could predict and compare the benefits of the 6-month regimen containing HRE in the continuation phase of the proposed regimen, i.e. 2HRZE/4HRE, and predict the outcomes of the new proposed regimen.Worldwide intermittent regimens are widely administered.The authors only predicted the benefits of daily regimens but remained silent about the intermittent therapy in their hypothetical cohorts.
Stroke volume calculated from the mitral valve echogram in patients with and without ventricular dyssynergy.
Authors: S Rasmussen, B C Corya, H Feigenbaum, M J Black, D E Lovelace, J F Phillips, R J Noble, S B Knoebel
Journal: Circulation (1978)

A formula was derived for calculating mitral valve stroke volume (MVSV) using the rate of mitral valve (MV) opening (DE slope on the MV echogram), the vertical disease between the mitral leaflet echoes early in diastole (EE), the electrocardiographic PR interval and heart rate. The formula was tested prospectively on 80 consecutive patients from whom 95 simultaneous MV echograms and either thermodilution (45) or Fick (50) cardiac outputs were obtained. Sixteen patients were normal; 54 had coronary artery disease; three had cardiomyopathy; and seven had nonrheumatic mitral regurgitation (MR). Linear regression for stroke volume was r = 0.90, SEE +/- 6, and for cardiac output r = 0.83, SEE +/- 0.5 liter for the 73 patients without MR. The presence or absence of ventricular dyssynergy did not alter statistical findings. MVSV consistently overestimated forward stroke volume for the seven patients with MR. This study shows that the MV echogram provides an accurate, widely applicable method for calculating MVSV.
Short‐term and long‐term failure of laparoscopic splenectomy in adult immune thrombocytopenic purpura patients: A systematic review
Authors: Joseph Mikhael, Kelly Northridge, Karla Lindquist, Craig Kessler, Robert Deuson, Mark Danese
Journal: American Journal of Hematology (2009)

Splenectomy is a common therapy for adults with chronic idiopathic thrombocytopenic purpura (ITP). Thisstudy was designed to estimate both the short-term surgical non-response rate and the long-term relapse rate after laparoscopic splenectomy. A systematic review was conducted of articles published between January 1, 1991 and January 1, 2008. Selection criteria included: chronic ITP, study enrollment in 1990 or later, > or =12 months of follow-up, > or =15 patients with ITP, > or =75% of patients at least 14 years of age, not HIV positive, not undergoing a second splenectomy, and type of performed splenectomy clearly reported. Data were pooled across studies to estimate rates. We identified 170 articles, of which 23 met our inclusion criteria (all observational studies). These studies represent 1,223 laparoscopic splenectomies (71 or 5.6% were converted to open splenectomy during surgery). The pooled short-term surgical non-response rate among the 18 studies reporting data was 8.2% (95% CI 5.4-11.0). The pooled long-term relapse rate across all 23 studies was 43.6 per 1,000 patient years (95% CI 28.2-67.2). This translates to an approximate failure rate of 28% at 5 years for all patients undergoing splenectomy. Studies with shorter durations of follow-up had significantly higher pooled relapse rates than studies with longer follow-up (P = 0.04). Laparoscopicsplenectomy is effective for most patients. Splenectomy may have higher initial relapse rates, particularly, in the first 2 years after surgery, and the rate may decline over time. Am. J. Hematol. 2009. (c) 2009 Wiley-Liss, Inc.
IMPACT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ON VARC-DEFINED OUTCOMES AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION: RESULTS FROM THE FRANCE 2 REGISTRY
Authors: Romain Chopard, Nicolas Meneveau, Sidney Chocron, Marie-France Seronde, Martine Gilard, Marc Laskar, Helene Eltchaninoff, Bernard Iung, Pascal Leprince, Emmanuel Teiger, Karine Chevreul, Alain Prat, Michel Lievre, Alain Leguerrier, Patrick Donzeau-Gouge, Jean Fajadet, Francois Schiele
Journal: Journal of the American College of Cardiology (2014)
MECHANICAL REMEDIES IN THE TREATMENT OF SKIN DISEASES.
Authors: John V. Shoemaker
Journal: JAMA (1883)

[Read to the Section on Practice of Medicine, Materia Medica, etc, June, 1883.] Gentlemen: I do not propose to read my paper in extenso before the Section this afternoon, but while giving its salient points, I shall reserve for publication, in case of acceptation, its entirety. There are a number of remedies which can be used in the treatment of skin diseases which cannot be classed as drugs, but being mechanical in their application may be appropriately termed mechanical remedies. They are massage, compression, blood-letting, incision, excision, enucleation, scooping, scraping, setons, and cauterization, remedial measures which have been in vogue almost from time immemorial, but which have been more or less lost sight of, and seldom, if ever, used by therapeutists in the treatment of cutaneous diseases. These are all valuable agents, as I can attest from a long personal experience with them, and I now will proceed to relate