tbuckley/cabot-search huggingface dataset:
Evaluating Quality of Care for Patients With Heart Failure
Authors: Harlan M. Krumholz, David W. Baker, Carol M. Ashton, Sandra B. Dunbar, Gottlieb C. Friesinger, Edward P. Havranek, Mark A. Hlatky, Marvin Konstam, Diana L. Ordin, Ileana L. Pina, Betram Pitt, John A. Spertus
Journal: Circulation (2000)
US anti-abortion groups say health reform package should not pay for abortion
Authors: J. H. Tanne
Journal: BMJ (2009)

Anti-abortion groups in the United States are protesting against proposed healthcare reform bills because they claim that they will force all Americans to pay for abortions through their tax dollars.

Although current discussions focus on how universal health care will be funded, abortion is another potential road block to the passing of the bills.

President Barack Obama has said that he seeks common ground on abortion and wants to reduce the number of unintended pregnancies.

The proposed healthcare reform bills, which are working their way through committees in the House of Representatives and the Senate, do not specify what health and medical services they will cover. President Obama had called for passage of a health reform bill before Congress leaves for its August recess, but voting has been delayed until Congress returns in September (see News, …
Three cases of anorexia nervosa
Authors: J. Hollis-Triantafillou
Journal: BMJ (1995)

She is an intelligent 18 year old who has reluctantly agreed to see me with her mother, who is consumed with anxiety over her daughter's abnormal eating habits. Alexia denies there's a problem and we arrange a new appointment alone. She is on the 85th and 25th centiles for height and weight respectively, menarche at 13, periods always slightly irregular. Boyfriends? She's a bit choosy, avoiding emotional involvement for the time being because she's working for exams. Diet? Vegetarian by choice but with a reasonable understanding of the elements of a healthy diet. Her psychological state seems normal. I warn her of the possible consequences of extreme dieting and reassure her mother. Six months later, studying archeology and living away from home, she's lost four …
Importance of collateral circulation for prevention of left ventricular aneurysm formation in acute myocardial infarction.
Authors: T Hirai, M Fujita, H Nakajima, H Asanoi, K Yamanishi, A Ohno, S Sasayama
Journal: Circulation (1989)

The effect of preexistent coronary collateral perfusion on the prevention of left ventricular aneurysm formation was examined in 47 patients undergoing an intracoronary thrombolysis within 6 hours after the onset of a first acute anterior myocardial infarction. Left ventricular aneurysm formation and wall motion were analyzed with cineventriculography. A left ventricular aneurysm was determined as well-defined demarcation of the infarcted segment from normally contracting myocardium. In 25 patients with successful thrombolysis (group A), a left ventricular aneurysm was observed in one patient (4%) during the chronic stage of infarction. In 10 patients who had a significant collateral circulation to the infarct-related coronary artery and unsuccessful reperfusion (group B), the left ventricular aneurysm was observed in only one patient (10%). In the remaining 12 patients with unsuccessful recanalization in the absence of a significant collateral perfusion (group C), there was a higher incidence (seven of 12, 58%) of left ventricular aneurysm formation than in groups A and B (p less than 0.05). In group A, both the global ejection fraction and regional wall motion in the infarct areas improved significantly (p less than 0.05) between the acute and chronic stages of infarction. By contrast, in groups B and C, these indexes on the ventricular function did not change significantly during the convalescent period. Thus, although the collateral perfusion existing at the onset of acute myocardial infarction may not improve ventricular function, it exerts a beneficial effect on the prevention of left ventricular aneurysm formation.
POMPHOLYX ERUPTION DUE TO IODINE APPLIED EXTERNALLY.
Authors: R. T. BRAIN
Journal: British Journal of Dermatology (1926)

Journal Article POMPHOLYX ERUPTION DUE TO IODINE APPLIED EXTERNALLY. Get access R. T. BRAIN, M.B., M R.C.P. R. T. BRAIN, M.B., M R.C.P. House Physician to the Skin Department, London Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 38, Issue 5, 1 May 1926, Pages 191–192, https://doi.org/10.1111/j.1365-2133.1926.tb09989.x Published: 01 May 1926
A METHOD OF EVALUATING CARDIAC PAIN IN CHILDREN
Authors: HAROLD C. LUETH
Journal: JAMA (1935)

Pain is a valuable symptom in the diagnosis of cardiac conditions. In angina pectoris, for example, one patient may complain of a viselike constriction of the chest and another may merely experience a deep dull sensation that he dismisses as a transient numb feeling over the heart. This variation of response, as well as the different descriptions given by patients,<sup>1</sup>makes pain an equivocal symptom. However, it is not to be expected that all patients will give the same response to a given pathologic condition, nor even is it seen in the same individual at all times. Much of this apparent difficulty in the evaluation of pain can be overcome by taking a careful history and estimating the patient's sensitivity to pain by past experience. We have long been perplexed by the child who complains of a pain over the heart. A complete history of this disorder or an
DO WE NEED ETHNICITY-SPECIFIC GUIDELINES FOR PRE-PARTICIPATION SCREENING OF ATHLETES?
Authors: Nabeel Sheikh, Michael Papadakis, Saqib Ghani, Abbas laidi, Sabiha Gati, Navin Chandra, Rachel Bastiaenen, Lynne Millar, Noel Emmanuel, Sanjay Sharma
Journal: Journal of the American College of Cardiology (2012)
Fluid Phase Endocytosis Contributes to Transfection of DNA by PEI-25
Authors: Hansjörg Hufnagel, Parvez Hakim, Aline Lima, Florian Hollfelder
Journal: Molecular Therapy (2009)

The understanding of internalization pathways of lipo- or polyplexes is crucial for engineering successful reagents for nonviral gene transfection. A known inhibitor of fluid phase endocytosis (FPE), rottlerin, was used to quantify the contribution of this pathway by flow cytometric and fluorescence assays. Rottlerin was shown to be a specific inhibitor of transfection by polyethylene imine (PEI-25)/DNA complexes, leading to a decrease in the amount of transfected HeLa and CHO-K1 cells and a decrease in the expression of enhanced green fluorescent protein (EGFP) reporter gene by up to 50%. Experiments using fluorescently labeled polyplexes result in a decrease of uptake by up to 40%. Additionally, rottlerin does not cross-inhibit clathrin- and caveolin-mediated endocytotic pathways of internalization, consistent with direct uptake inhibition by rottlerin. Nonspecific effects as a result of toxicity were ruled out by control experiments at concentrations where rottlerin inhibition was specific. These findings suggest that for CHO-K1 and HeLa cells, internalization of PEI-25/DNA complexes by FPE plays a decisive role in gene transfection. The establishment of an additional pathway that is independent of clathrin- and caveolin-mediated endocytotic uptake may have an impact on the design of future reagents of nonviral gene therapy and investigations of the uptake pathways and intracellular trafficking involved.
Tc-99m HMDP and Ga-67 Imaging Along With CT and MRI in Fibrous Dysplasia of the Temporal Bone
Authors: HITOYA OHTA, MASATO HOJO, MAYASUKI SHINTAKU, TOMOO KOMIBUCHI, SHINICHIROU OKAMOTO
Journal: Clinical Nuclear Medicine (1997)

The authors report the use of Tc-99m HMDP and Ga-67 citrate imaging in fibrous dysplasia of the temporal bone along with CT and MRI.
Letter Regarding Article by Augé et al, “Role for Matrix Metalloproteinase-2 in Oxidized Low- Density Lipoprotein-Induced Activation of the Sphingomyelin/Ceramide Pathway and Smooth Muscle Cell Proliferation”
Authors: Cemil Izgi, Cihan Cevik, Mehmet Ozkan
Journal: Circulation (2005)

We have read the recent article by Augé et al 1 with great interest.The authors demonstrated the role of matrix metalloproteinase (MMP)-2 in oxidized (ox)-LDL-induced sphingolipid signaling and smooth muscle cell (SMC) proliferation.We have several comments about their findings and statements.The authors depicted the activated neutral sphingomyelinase (SMase) as the membrane-bound form of the enzyme.However, as far as we know, the precise cellular localization of the signaling sphingomyelinase in the ox-LDL-treated SMC is still not exactly clear.Wherever the enzyme is located, the critical point, as stated also by the authors, is how the extracellular ox-LDL is linked to the signaling SMase.The authors suggest this link to be MMP-2, subsequent to its activation by membrane type 1 (MT1)-MMP.However, although the results of their experiments underline the novel, crucial role of both MT1-MMP and MMP-2 in ox-LDLinduced SMase activation, they do not discriminate whether MT1-MMP or MMP-2 is the final link to SMase activation and SMC proliferation.MT1-MMP, with its already existing link to the cytoplasm by its intracytoplasmic domain and predominant location in the caveolae, takes part in signal transduction and ERK activation 2 and may also be the link between ox-LDL and SMase.The experiments by Gingras et al 2 showed that MT1-MMP induced ERK activation when overexpressed in migrating endothelial cells.However, this effect was abolished when a catalytically inactive mutated form of MT1-MMP, which was unable to activate proMMP-2, was expressed or when a tissue inhibitor of MMP-2 activation, TIMP-2, was added.When the intracytoplasmic domain partially truncated mutant of MT1-MMP was expressed, ERK activation did not occur although MMP-2 activation was still occurring.Thus, MT1-MMP-induced MMP-2 activation is a prerequisite, however it is not sufficient to activate ERK, which is dependent on MT1-MMP-induced signaling by its cytoplasmic domain.Although this cascade may be cell type specific and may not necessarily operate in SMC, catalytically active and substrate (MMP-2) available MT1-MMP rather than MT1-MMP-activated MMP-2 may be the link for ox-LDL-induced SMase activation and SMC proliferation.Finally, besides the relatively predictable effect that statins-by reducing MMP-2 expression-may have on this signaling cascade, whether it will also be affected by cyclooxygenase inhibitors, which dose dependently increase the SMase activator arachidonate levels, 3 will be of great concern.
Progressive Loss of Myocardial ATP Due to a Loss of Total Purines During the Development of Heart Failure in Dogs
Authors: Weiqun Shen, Kuniya Asai, Masami Uechi, Michael A. Mathier, Richard P. Shannon, Stephen F. Vatner, Joanne S. Ingwall
Journal: Circulation (1999)

Background —Whether myocardial ATP content falls in heart failure is a long-standing and controversial issue. The mechanism(s) to explain any decrease in ATP content during heart failure have not been identified. Methods and Results —Cardiac dysfunction, heart failure, and a prolonged steady state of heart failure were induced by chronic right ventricular pacing for 1 to 2 weeks, 3 to 4 weeks, and 7 to 9 weeks in dogs. Cardiac function and myocardial O 2 consumption (MV̇ o 2 ) were measured with the dogs in the conscious state. ATP, total purine, and creatine were measured in biopsy specimens obtained at each stage. ATP and the total purine pool progressively fell at rates of 0.12 and 0.15 nmol · mg protein −1 · d −1 , despite an increase in MV̇ o 2 . The rate of loss of creatine was 1.06 nmol · mg protein −1 · d −1 , 7 times faster than the depletion of total purine. Conclusions —(1) ATP contents progressively decreased during heart failure as a result of a loss of the total purine pool. The loss of purines may be due to inhibition of de novo purine synthesis. (2) Loss of creatine is an early marker of heart failure and may serve as a compensatory mechanism minimizing the reduction of the total purine pool in the failing heart.
Diabetic Cutaneous Atrophy and Malignant Melanoma
Authors: LORNE D. FELDMAN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 July 1986Diabetic Cutaneous Atrophy and Malignant MelanomaLORNE D. FELDMAN, M.D.LORNE D. FELDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-1-142_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Risk factors for the development of malignant melanoma include exposure to ultraviolet light, the degree of skin pigmentation (1), and the presence of dysplastic nevi, especially familial dyplastic nevi (2). Malignant melanoma has also been reported to develop in vaccination scars and a tattoo (3).Vasculopathy due to involvement of both small and large blood vessels and neuropathy are the commonest causes of cutaneous abnormalities occurring in patients with diabetes mellitus. These cutaneous lesions progress with increasing duration of diabetes, and regression is uncommon despite optimal medical and surgical management. We report the case of a patient...References1. FITZPATRICK T, EISEN A, WOLFF K, FREEDBERG I, and AUSTEN K. Dermatology in General Internal Medicine. 2nd ed. New York: McGraw-Hill; 1979:629-54. Google Scholar2. GREENE M, CLARK J, and WALLACE H. Acquired precursors of cutaneous malignant melanoma: the familial dysplastic nevus syndrome. N Engl J Med. 1985;312:91-7. CrossrefMedlineGoogle Scholar3. MOSCHELLA S and HURLEY H. Dermatology. 2nd ed. Philadelphia: W.B. Saunders Company; 1985:1574-80. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LORNE D. FELDMAN, M.D.Affiliations: University of Toronto, Toronto Western Hospital Toronto, Ontario M5T 2S8 Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMalignant Melanoma and Diabetic Cutaneous AtrophyWALTER H. C. BURGDORF, M.D. 1 July 1986Volume 105, Issue 1Page: 142-143KeywordsAtrophyBlood vesselsDiabetes mellitusLesionsMedical risk factorsMelanomaNeuropathyScars ePublished: 1 December 2008 Issue Published: 1 July 1986 PDF downloadLoading ...
Concordance and children's use of medicines
Authors: E. J Sanz
Journal: BMJ (2003)

Doctors are expected to encourage patients' involvement in treatment decisions, but what about children? This article considers the issues 

Concordance is usually established between two people, doctor and patient, but the use of drugs in children always involves a third partner, the parents. Developing concordance with children in their health care raises several questions with no straightforward answers. For example, should children have a more active role in taking decisions about health and drugs than they currently do? Should greater emphasis be placed on informing parents about the disease and its treatment or on direct communication with their sick child? From what age should children be addressed directly about their illness? What is really relevant for them? Do children's and parents' perceptions about the usefulness and risks (efficacy), rules, and use of drugs coincide?

This article, based on qualitative studies of children's perceptions and attitudes to health, disease, and drug use, presents information that, though by no means providing the “right” answers to the above questions, might be useful when considering the options.

Most studies of patient compliance and the health education of children refer to the professional view and address compliance with drug use, usually related to specific disease treatment. Few address the general issue of how to improve compliance (or to create concordance). In spite of some outstanding systematic reviews from the Cochrane Consumers and Communication Group,1–3 few studies have examined patients' perspectives about drugs, and even fewer have studied children. Hopefully, the new Cochrane Qualitative Research Methods Group will address the topic.

Of particular value are several international studies supported by the European Union that compared healthy and asthmatic children in their knowledge, perceptions, and expectations about health, diseases, and treatment.4–6 The data presented in this article are based on those …
Some New Researches on the Cause and Origin of Fever from the Action of the Septinous Poisons
Authors: B. W. Richardson
Journal: BMJ (1875)

Experiment v. -Rabbit, weighing 2 lbs. 8ozs.One-thirtieth of a grain of picrotoxine 'was injected under the skin of the shoulder, at 6.54 P.IM. ; the normal temperature having been, by observations ex- tending over I5 minutes, ascertained to be io2.0deg.Fahr.Temperattire Temperature 6.55 P. ....
Encouraging Physical Activity
Authors: Frederic C. McDuffie
Journal: Annals of Internal Medicine (1998)

Letters1 April 1998Encouraging Physical ActivityFrederic C. McDuffie, MDFrederic C. McDuffie, MDPiedmont Rheumatology Consultants; Atlanta, GA 30309Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I heartily endorse Andersen and colleagues' message in the article on the physician's role in encouraging patients to become more physically active [1]. The authors provide evidence for the medical benefits of regular exercise and provide useful advice for physicians in getting their patients to cooperate in such programs. Only in the last sentence, however, do they refer to one of the most important elements in persuading patients to follow such a program-the physicians' own commitment to such a program themselves.I am a 73-year-old physician in full-time active practice who runs 35 miles a week, works ...References1. Andersen RE, Blair SN, Cheskin LJ, Bartlett SJ. Encouraging patients to become more physically active: the physician's role. Ann Intern Med. 1997; 127:395-400. Google Scholar Author, Article, and Disclosure InformationAffiliations: Piedmont Rheumatology Consultants; Atlanta, GA 30309 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 605-606KeywordsExercisePainRacial and ethnic issuesRheumatic pain Issue Published: 1 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Fifteenth Annual Pezcoller Symposium
Authors: Enrico Mihich, William Kaelin
Journal: Cancer Research (2004)

Recent advances in the understanding of the molecular phenomena underlying neoplastic development are leading to the recognition of metabolic features characteristic of the cancer cell. It has become possible to visualize the presence of these cells in vivo and to follow their progression toward increasing anaplastic behavior through measurements of molecular markers that can be achieved by physical or biochemical means.
'Do Not Resuscitate' Orders
Authors: Rodney J. Simonsen
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I am concerned that we may be misinterpreting the order "do not resuscitate" (DNR). This order does not always reflect our concerns about a patient's current situation, but is merely a statement regarding the decision that has been made about the next catastrophic event that may occur in that person's life. A DNR order, while frequently written for patients who are not expected to return to a truly gainful or meaningful life, is not too different from a "living will," which many of us have executed. The living will merely makes a declaration about a catastrophic medical event that may occur in someone's life in the future, and is in essence a DNR statement in a situation where resuscitation will probably not lead to normal recovery. I do not think that medical services should be withheld from patients who are now living merely because a decision has
Regulation Of Anticonvulsant-induced T Cell Responsiveness By Cd4+Cd25+Cd127Low Cells In Patients With Drug Allergy Reactions
Authors: C. Antunez, M.J. Sanchez-Quintero, C. Mayorga, M.J. Torres, D. Ruíz, M. Blanca, A. Romano
Journal: Journal of Allergy and Clinical Immunology (2011)
Small intestinal bacterial flora and folate status in gastrointestinal disease
Authors: A. V. Hoffbrand, S. Tabaqchali, C. C. Booth, D. L. Mollin
Journal: Gut (1971)

Serumfolate folate levels and the bacteriology of the small intestine were studied in 13 patients with jejunal diverticulosis, 29 patients with partial gastrectomy, and five patients with ileal disease. The mean serum folate level in the patients with partial gastrectomy (7.2 mmug/ml) was similar to that of control subjects but the mean level in the patients with jejunal diverticulosis (14.6 mmug/ml) was significantly higher than the mean level of the control group (8.0 mmug/ml). Five of the 13 patients with jejunal diverticulosis and two of the patients with partial gastrectomy had levels above the upper limit of the control group (> 16.6 mmug/ml), and five of six patients with jejunal diverticulosis studied excreted raised amounts of folate in the urine (> 13.2 mug in 24 hours). Serum folate in one of these patients with jejunal diverticulosis was identified chromatographically as 5-methyltetrahydrofolic acid. The mean serum folate level (9.0 mmug/ml) in the patients with partial gastrectomy who had Esch. coli in the jejunal aspirates was significantly higher than in those without Esch. coli present (mean 4.2 mmug/ml). It is suggested that in gastrointestinal disease jejunal bacteria may contribute to the serum folate level even though this remains in an accepted normal range. Some patients had low serum folate levels despite having a large number of Esch. coli in the jejunum. No evidence of malabsorption of folic acid was found in three such patients even though one had lactobacilli capable of consuming folate in the jejunum. No relationship was found between serum folate level and ileal bacteriology.
Emotional Behavior and the Brain
Authors: H. Nakao
Journal: Psychotherapy and Psychosomatics (1979)

Basic behaviors were defined as those controlled by the hypothalamus, and emotion and instinct were defined as the drives of such behaviors. A learning method showed that fear-escape is obtained from the medial hypothalamic area except for the ventromedial nucleus. It was suggested that some neural systems responsible for threat, attack, rush and retreat are overlapped in the ventromedial nucleus. Functions of the amygdala and the septum were discussed in relation to hypothalamic activity in emotional behavior. A behavioral sequence composed of stimulation, classical conditioning, drive, reward learning and behavior was discussed, and learning, anxiety in neuroses and Morita therapy were examined from the viewpoint of the behavioral sequence.