Hemodynamic and Metabolic Studies on Shock Associated with Bacteremia
Authors: VASANT N. UDHOJI
Journal: Annals of Internal Medicine (1965)

Article1 May 1965Hemodynamic and Metabolic Studies on Shock Associated with BacteremiaObservations on 16 PatientsVASANT N. UDHOJI, M.B., B.S., MAX HARRY WEIL, M.D., PH.D., F.A.C.P.VASANT N. UDHOJI, M.B., B.S., MAX HARRY WEIL, M.D., PH.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-966 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute hypotension and clinical features of shock may be presenting features in patients who have bacteremia caused by endotoxin-producing gram-negative bacteria. Our present understanding of the hemodynamic abnormalities in this type of shock is incomplete, and current concepts of pathophysiology are largely based on animal studies. The extrapolation of findings in experimental animals to the understanding of bacterial shock in human patients is difficult because of species differences, the artificiality of an experimental model that employs single injections of endotoxins, and the special circumstances of infection and underlying disease in human patients (1, 2).Two years ago, we (3) reported...References1. ZWEIFACH BW: Aspects of comparative physiology of laboratory animals relative to the problem of experimental shock. Fed. Proc. 20: 18, 1961. MedlineGoogle Scholar2. SPINKANDERSON WWD: Experimental studies on the significance of endotoxin in the pathogenesis of brucellosis. J. Clin. Invest. 33: 540, 1954. CrossrefMedlineGoogle Scholar3. UDHOJIWEILSAMBHIROSOFF VNMHMPL: Hemodynamic studies on clinical shock associated with infection. Amer. J. Med. 34: 461, 1963. CrossrefMedlineGoogle Scholar4. WEILSPINK MHWW: The shock syndrome associated with bacteremia due to gram-negative bacilli. Arch. Intern. Med. 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Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: VASANT N. UDHOJI, M.B., B.S.; MAX HARRY WEIL, M.D., PH.D., F.A.C.P.Affiliations: Los Angeles, CaliforniaFrom the Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, and the Los Angeles County Hospital, Los Angeles, Calif.This study was supported by The John A. Hartford Foundation, Inc., New York, and by grants HE-05570 and HE-07811 from the National Heart Institute, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Max Harry Weil, M.D., Ph.D., Department of Medicine, University of Southern California School of Medicine, 2025 Zonal Avenue, Los Angeles, Calif. 90033. 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Septic Shock–Pathogenesis and TreatmentIsoproterenol in the Treatment of Shock Due to Bacteremia with Gram-Negative PathogensCurrent status of the shock problem 1 May 1965Volume 62, Issue 5Page: 966-978KeywordsAnimal models of infectionBacteremiaBacterial diseasesCirrhosisHemodynamicsHospital medicineMedical servicesNursesShockTechnicians ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...