Acute Renal Failure Related to High-Dose Celecoxib
Authors: Mark G. Graham
Journal: Annals of Internal Medicine (2001)

Letters3 July 2001Acute Renal Failure Related to High-Dose CelecoxibMark G. Graham, MDMark G. Graham, MDJefferson Medical College; Philadelphia, PA 19107 (Graham)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-1-200107030-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 57-year-old woman developed acute renal failure on 6 July 2000. She had been prescribed celecoxib, 200 mg/d, 10 months earlier for symptomatic osteoarthritis and had been followed with bimonthly visits thereafter. Her baseline creatinine and blood urea nitrogen (BUN) levels were normal at 88 µmol/L (1.0 mg/dL) and 3.9 mmol/L (11 mg/dL), respectively. In the last half of June 2000, her orthopedist doubled the daily celecoxib dose to 400 mg. Two weeks later, on 6 July 2000, she presented with marked dependent edema and markedly elevated blood pressure (160/110 mm Hg). Creatinine and BUN levels were ...References1. Perazella MA, Eras J. Are selective COX-2 inhibitors nephrotoxic? Am J Kidney Dis. 2000;35:937-40. [PMID: 0010793030] CrossrefMedlineGoogle Scholar2. Moreland LW, St Clair EW. The use of analgesics in the management of pain in rheumatic diseases. Rheum Dis Clin North Am. 1999; 25:153-91, vii. [PMID: 0010083963] Google Scholar3. Brater DC. Effects of nonsteroidal anti-inflammatory drugs on renal function: focus on cyclooxygenase-2-selective inhibition. Am J Med. 1999;107:65S-71S. [PMID: 0010628595] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Jefferson Medical College; Philadelphia, PA 19107 (Graham) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced Acute Kidney InjuryCelecoxibCOX-2 inhibitors (coxibs)NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)Renal adverse effects of nonsteroidal anti-inflammatory drugsLate-onset celecoxib-induced combined hepato-nephrotoxicityNormotensive Ischemic Acute Renal FailureClinical pharmacology of celecoxib, a COX-2 selective inhibitorCOX-2 inhibitorsCelecoxibSelektive Zyklooxygenase-2-Inhibitoren zur postoperativen SchmerztherapieComplications rénales des anti-inflammatoires non stéroïdiensParecoxib: a shift in pain management?Renal effects of etoricoxib and comparator nonsteroidal anti-inflammatory drugs in controlled clinical trialsCOX-2 inhibition and prostaglandin receptors in experimental nephritisAdverse Drug Events Involving COX-2 InhibitorsDrug-Induced Renal Failure: Update on New Medications and Unique Mechanisms of NephrotoxicityAudit of Selective and Non-Selective Non-Steroidal Anti-Inflammatory Drug Use in Rural General PracticeAnti-inflammatory and antipyretic analgesics and drugs used in goutEffects of NSAIDs on the Incidence of Hospitalisations for Renal Dysfunction in Users of ACE InhibitorsA clinical audit of the prescribing of celecoxib and rofecoxib in Australian rural general practiceCyclooxygenase Inhibition for Postoperative AnalgesiaCOX-2 selective inhibitors: analysis of the renal effectsCox-2 Inhibitors: Today and TomorrowBeneficios y riesgos de los antiinflamatorios no esteroides inhibidores selectivos de la ciclooxigenasa-2Anti-inflammatory and antipyretic analgesics and drugs used in goutUse of nonopioid analgesics and adjunctive agents in the management of pain in rheumatic diseasesA Comparison of Adverse Renovascular Experiences Among Osteoarthritis Patients Treated with Rofecoxib and Comparator Non-selective Non-steroidal Anti-inflammatory AgentsRenal Failure Associated with the Use of Celecoxib and RofecoxibAcute Renal Failure Can Occur with Inappropriate Use of a CoxibRisk Factors for Adverse Drug Events in Nursing Home Residents/Movement Disorder Caused by Cough Syrup/Visual Disturbance with Mirtazapin/Acute Renal Failure Associated with Celecoxib/Rhabdomyolysis with Cerivastatin/Liver Toxicity with an Herbal Preparation/Sulfamethoxazole/Trimethoprim-Induced Toxic Epidermal NecrolysisCelecoxib 3 July 2001Volume 135, Issue 1Page: 69-70KeywordsAcute renal failureAnalgesicsBlood urea nitrogenCreatinineDrugsEdemaNSAIDsProstaglandinsRenal diseasesSodium ePublished: 3 July 2001 Issue Published: 3 July 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...