tbuckley/cabot-search huggingface dataset:
Vasodilator therapy for chronic left ventricular failure.
Authors: R B Kovick, J H Tillisch, S C Berens, A D Bramowitz, K I Shine
Journal: Circulation (1976)

The effects of chronic oral vasodilator therapy were studied in a group of patients with refractory congestive heart failure. Fifteen patients were treated acutely with intravenous sodium nitroprusside and sublingual isosorbide dinitrate. After continuous therapy with nitroprusside and isosorbide dinitrate for up to 72 hours the patients were then placed on isosorbide dinitrate and oral phenoxybenzamine. Hemodynamic responses to nitroprusside, isosorbide dinitrate, and phenoxybenzamine with isosorbide dinitrate were determined. After a mean follow-up of seven months, nine patients who were receiving isosorbide dinitrate and phenoxybenzamine underwent repeat hemodynamic studies. Beneficial effects of acute vasodilator therapy included a significant reduction in pulmonary capillary wedge pressure and systemic vascular resistance, and significant increases in cardiac index and stroke work index. Mean arterial blood pressure and heart rate were unchanged. During the period of chronic vasodilator administration, no other change in basic therapy with isosorbide dinitrate and phenoxybenzamine (3-21 months), the favorable effects observed acutely were maintained. All patients demonstrated symptomatic improvement with minimal side effects. The beneficial hemodynamic responses that are noted with acute vasodilator therapy in patients in advanced congestive heart failure are maintained with oral therapy on a chronic basis.
Marcus Alexander Sleightholm
Authors: R. Davies, M. Smith
Journal: BMJ (2009)

Rhys Davies writes:

Marcus Alexander Sleightholm was a singular soul who was unlike anyone we are likely to meet again.

After qualifying and house jobs at the Royal Liverpool Hospital he worked at the Hammersmith Hospital in London and Addenbrooke’s in Cambridge before moving to Leeds.

He had many interests outside medicine, in particular amateur radio and sailing. He was an accomplished photographer (much of his work has been published, and he recorded our medical student days!), and he was a splendid jazz guitarist, which was his greatest love.

Marcus lived alone but leaves his father and two sisters (his mother and brother predeceased him). He also leaves many friends.

Mike Smith writes a eulogy for Marcus:

Introduction

Marcus was a singular soul who was unlike anyone we are ever likely to meet again.

I’ve only really known Marcus well for about 12 years, but in that time he has become a close friend. He was a complex and multifaceted man, and before I try to convey a glimpse into the different aspects of Marcus’s rich life, I’d like to read some of the tributes from friends, which poured in by phone, text, and email:

“Apart from being very clever he was also really kind. which I find a very unusual combination.”

“He was a delightful quirky man, whose company we always found stimulating.”

“He had a very dry sense of humour—a bit too dry for me at times, but that was Marcus.”

“There was a deep underlying spirit of generosity and fair play.”

“Perfect gentleman. Loyal friend. Never heard him swear or be nasty, cruel, or unkind.”

“Mind you he can be a grumpy bugger at times.”

“He always acted honourably and expected others to do the same.”

“He made a great impression on others in his life and …
Obesity
Authors: JOSEPH EIDELSBERG
Journal: Annals of Internal Medicine (1929)

Article1 December 1929ObesityProcedure, Classification, Treatment, And Results, In 151 Cases Studied During The Past Six Years, With Special Reference to An Endocrinopathic Origin.*JOSEPH EIDELSBERG, M.D.JOSEPH EIDELSBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-6-604 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMuch has been written on the subject of Obesity, and the literature on the study of the condition is certainly voluminous. However, there still remains a vast amount to be uncovered, and explained. Recently there have appeared several expressions of doubt as to an endocrinogenic factory in obesity,1'2and placing its incidence below one per cent. No "normal healthy adult" measures his food intake in grams of carbohydrate, fat and protein, and then, to keep his weight stationary, proceeds to work and exercise, play and rest in a measured caloric-equivalent amount. Still, some will gain weight, while others on the...References1 EVANSSTRONG FAJM: A Departure From the Usual Methods in Treating Obesity. Am. J. of Med. Sc., March, 1929. CrossrefGoogle Scholar2 BAUMAN L: Obesity—Recent Reports in the Literature and Results of Treatment. J. A. M. A., Jan. 7, 1928, Vol. p. 22. CrossrefGoogle Scholar3 GRAFEGRAHAM E: Ueber die Aupassungsfa̋highkeit des Tierischen Organismus an uberreichliche Nahrungazufuhr. Ztsch. F. Physial. Chem. 73:, 1911. Google Scholar4 STROUSEDYE SM: Relation Between Food Intake and Body Weight in Some Obese Persons. Arch. Int. Med., Sept., 1924, p. 267. CrossrefGoogle Scholar5 VON NOORDEN C: Ueber die Verschiedenen Formen der Fettsucht. Med. Klin. 5:, 1909. Google Scholar6 HAGEDORN : Metabolism in Obesity. Arch. Int. Med., July, 1927, p. 37. Google Scholar7 JOHN HJ: Treatment of Obesity with Special Reference to Dangers in Use of Thyroid. Med. J. and Rec., Oct. 19, 1927, p. 476. Google Scholar8 STROUSE S: Studies on Metabolism of Obesity. Arch. Int., Med., Sept., 1924, p. 275. CrossrefGoogle Scholar9 HAUSSLEITER H: Ueber den Gas. verschiednen Formen von Fettsucht und seine Beeinflussung durch Nahrings-arbeit und Arzneimittel. Ztschr. f. exper. Path. u. Therap. 17:413, 1915. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York*From the Endocrine Clinic, Department of Medicine, New York Post Graduate Medical School and Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe treatment of obesity: An analysis of methods, results, and factors which influence success 1 December 1929Volume 3, Issue 6Page: 604-607KeywordsCarbohydratesEatingExerciseFatsGraduate medical educationHospital medicineObesityProteinsWeight gain Issue Published: 1 December 1929 PDF DownloadLoading ...
Do intravascular ultrasound predictors for target lesion revascularization apply to saphenous vein grafts?
Authors: Marco T. Castagna, Gary S. Mintz, Ellen Pinnow, Akiko Maehara, Javed M. Ahmed, Eugenio Stabile, Natalie Gevorkian, Daniela Claus, Martine Gillard, William O. Suddath, Lowell F. Satler, Augusto D. Pichard, Neil J. Weissman
Journal: Journal of the American College of Cardiology (2002)
Court allows preimplantation genetic diagnosis in Germany
Authors: A. Tuffs
Journal: BMJ (2010)

A decision last week by Germany’s Federal Supreme Court to acquit a gynaecologist of illegal abortion after he chose to carry out genetic diagnosis on several human embryos and discarded those with genetic defects has stirred a debate about the possible need for a new law tightening the rules on preimplantation genetic diagnosis.

The landmark ruling said that embryos created from in vitro fertilisation (IVF) can be screened for genetic defects before being implanted in the womb.

The 47 year old doctor, who was not identified, brought the case to court himself in 2006 to clarify the legal situation. He had already been acquitted in …
TCT-414 Dedicated 2-stent versus 1-Stent Strategy in Diabetic Patients with Complex 'True' Bifurcation Lesion PCI using Everolimus-Eluting Stent
Authors: Nisharahmed I. Kherada, Marco G. Mennuni, Omar A. Meelu, Samantha Sartori, Patrick Looser, Usman Baber, Swapna Sayeneni, Swathi Roy, Linsey Walker, Bibhu D. Mohanty, Matthew Tomey, Pedro R. Moreno, Prakash Krishnan, Jason Kovacic, Robert T. Pyo, Joe Sweeny, George Dangas, Roxana Mehran, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2013)
Airways disease: just nosing around?
Authors: G. K Scadding, H. H Kariyawasam
Journal: Thorax (2009)

regimens (simulating a clinical trial) for our patients.In a study evaluating metered dose inhaler compliance in COPD, use of an electronic medication monitor with feedback on the accuracy of medication use improved compliance. 11This type of methodology could be used to improve adherence in COPD outside a clinical trial.Clearly, further research is needed to better understand the factors driving the phenomenon of improved outcomes in adherers.While it is disappointing that neither treatment with active drug nor disease severity had an impact on adherence, study participation was better in the combination treatment arm of the TORCH study which suggests that symptomatic improvement may positively affect the likelihood of compliance of a patient with COPD in the more global sense.This would be good news for our patients as the current analysis also suggests that the association between adherence and mortality risk reduction with combination therapy was even greater when only those in the treatment arm were analysed.
Audit of elderly people's eye problems and non-attendance at hospital eye service
Authors: J G Hillman
Journal: BMJ (1994)

<h3>Abstract</h3> Neurobiological pain models propose that the transition from acute to chronic pain is accompanied by neuropathological adaptations that mediate progressive pain processing dysfunctions. In contrast, meta-analytic studies on neurofunctional dysregulations in chronic pain have not revealed convergent evidence for robust alterations during experimental pain induction. Against this background, the present neuroimaging meta-analysis combined three different meta-analytic approaches with stringent study selection criteria for case-control functional magnetic resonance imaging experiments during acute pain processing with a focus on chronic pain disorders (i.e., fibromyalgia, irritable bowel syndrome, chronic low back pain, neuropathic pain; n = 295 patients, n = 211 controls; 86 foci). Across the meta-analytic approaches, convergent neurofunctional dysregulations in chronic pain patients were observed in the left anterior insula cortex, with study characteristics indicating generalized pain processing abnormalities. Seed-based resting-state functional connectivity based on a large publicly available dataset combined with a meta-analytic task-based approach identified the anterior insular region as a key node of an extended bilateral insula-fronto-cingular network, resembling the salience network. Moreover, the meta-analytic decoding showed that this region presents a high probability to be specifically activated during pain-related processes. Together, the present findings indicate that dysregulated left anterior insular activity represents a robust neurofunctional maladaptation and potential treatment target in chronic pain disorders.
Computed Tomographic Scanning of the Thorax in the Staging of Bronchogenic Carcinoma
Authors: George H. Underwood, Robert G. Hooper, Stewart P. Axelbaum, Donald W. Goodwin
Journal: New England Journal of Medicine (1979)

COMPUTED tomography (CT) of the thorax is now being used on a worldwide basis to evaluate various aspects of chest disease. It has been found to be the most sensitive noninvasive technic to detect pulmonary nodules.1 , 2 Several authors3 4 5 have recently proposed and reported the use of CT scans of the thorax as a staging technic for bronchogenic carcinoma. Studies reported to date have compared CT to conventional noninvasive staging technics, and in one study,5 CT has on occasion replaced invasive staging procedures. A lack of radiologic, CT and pathological correlation led us to compare the results of CT scans of . . .
Allogeneic bone marrow transplantation for leukemia following piperazinedione and fractionated total body irradiation
Authors: Meletios A. Dimopoulos, Jonathan C. Yau, Susan D. Huan, Sundar Jagannath, Gary Spitzer, Jorge A. Spinolo, Gunar K. Zagars, Charles F. Lemaistre, Karel A. Dicke, Axel R. Zander
Journal: American Journal of Hematology (1994)

Abstract Between 1980 and 1988, 126 patients with leukemia were treated with piperazinedione and fractionated total body irradiation (TBI) followed by allogeneic bone marrow transplantation from HLA matched siblings. Sixty‐one patients had acute myelogenous leukemia, 46 acute lymphoblastic leukemia, and 19 chronic myelogenous leukemia. Patients with acute leukemia in first complete remission were transplanted only if perceived to have a low probability of remaining in remission with conventional therapy. The toxicity from the preparative regimen was similar to that of cyclophosphamide and TBI except that none of the patients in the study had hemorrhagic cystitis or veno‐occlusive disease. After a median follow up of 114 months, 29 patients (23%) are still alive without relapse. The survival of patients with acute myelogenous or lymphoblastic leukemia transplanted in their first remission were 35% and 43%, respectively. The survival of patients transplanted in their first chronic phase of chronic myelogenous leukemia was 60%. The results of this preparative regimen are comparable to those of cyclophosphamide and TBI. © 1994 Wiley‐Liss, Inc.
A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors
Authors: Wei Zhang, Fannie St-Gelais, Chad P. Grabner, Jonathan C. Trinidad, Akio Sumioka, Megumi Morimoto-Tomita, Kwang S. Kim, Christoph Straub, Alma L. Burlingame, James R. Howe, Susumu Tomita
Journal: Neuron (2009)
Problems associated with ultraviolet dosimetry in the photochemotherapy of psoriasis
Authors: A.V.J. CHALLONER, B.L. DIFFEY
Journal: British Journal of Dermatology (1977)

Journal Article Problems associated with ultraviolet dosimetry in the photochemotherapy of psoriasis Get access A.V.J. CHALLONER, A.V.J. CHALLONER Department of Photobiology, Institute of Dermatology, Homerton Grove, London Search for other works by this author on: Oxford Academic Google Scholar B.L. DIFFEY B.L. DIFFEY Department of Medical Physics, Kent and Canterbury Hospital, Canterbury, Kent Dr B.L. Diffey, Medical Physics Department, Kent and Canterbury Hospital, Canterbury, Kent CTi 3NG. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue 6, 1 December 1977, Pages 643–648, https://doi.org/10.1111/j.1365-2133.1977.tb14271.x Published: 01 December 1977
Materials for protein delivery in tissue engineering
Authors: Samuel P Baldwin, W Mark Saltzman
Journal: Advanced Drug Delivery Reviews (1998)

The ability of protein agents to modulate cellular behaviors, such as motility, proliferation, adhesion and function, is the subject of intense research; new therapies involving proteins will likely result. Unfortunately, many proteins have short half-lives and the potential for toxicity after systemic delivery, so traditional routes of administration are not appropriate. Alternate methods for sustained delivery of these agents to the desired cells and tissues in biologically active conformations and concentrations are necessary. Techniques similar to those long used in the controlled delivery of drugs have been used to administer certain growth factors to cells and tissues; although clinical success has been limited to date, studies in animal models suggest the potential for tremendous advances in the near future. This review outlines the basic technology of controlled protein delivery using polymeric materials, and discusses some of the techniques under investigation for the efficient administration of proteins in tissue engineering.
Characteristics and completeness of clinical trial registrations in psoriasis and atopic dermatitis
Authors: R.D. Quain, K.A. Katz
Journal: British Journal of Dermatology (2006)

Controversy over the failure to publish results of clinical trials linking antidepressant treatment to suicidal behaviour in adolescents has increased interest in clinical trial registration.To assess numbers, characteristics and completeness of registrations of trials for psoriasis and atopic dermatitis registered at two web-based trial registries: ClinicalTrials.gov and isrctn.org.In this cross-sectional study we identified trials by searching ClinicalTrials.gov and isrctn.org on 18 January 2006 for trials registered up to 31 December 2005. We included only trials of therapeutic interventions for atopic dermatitis or psoriasis. We ascertained the date of submission of registration, the funding source of the trial, and whether a registration listed the specific name of the intervention studied, the specific outcome measure used (e.g. "Psoriasis Area and Severity Index"), the criterion used to gauge success on the outcome measure (e.g. > or = 75% decrease), and the time at which the outcome would be assessed (e.g. at 12 weeks).There were 156 registered trials, including 128 (82%) at ClinicalTrials.gov [36 (23%) in atopic dermatitis, 92 (59%) in psoriasis] and 28 (18%) at isrctn.org [23 (15%) in atopic dermatitis, 5 (3%) in psoriasis]. Pharmaceutical companies funded 87 trials (56%), federal or governmental agencies 28 (18%), universities or organizations 21 (13%), and a combination of funders 20 (13%). Of atopic dermatitis trials (13 of 36) and (24 of 92) of psoriasis trials at ClinicalTrials.gov were registered in September 2005. The specific name of the intervention studied was listed in 150 registrations (96%), 89 (57%) listed the specific measure used, 69 (44%) listed the criteria to gauge success and 62 (40%) listed the time of assessment.While trial registrations in atopic dermatitis and psoriasis are increasing, more complete information in these registrations may increase their value for dermatologists and their patients.
Benzodiazepine Prescription Regulation
Authors: Richard M. Glass
Journal: JAMA (1991)

Among the festering issues in the current turmoil of health care policy in the United States, two of the most hotly debated are physician autonomy and the use of outcome measures to assess quality of care. Physicians generally resent intrusions on their professional autonomy and often cite such intrusions by government regulations and managed-care insurance programs as major sources of dissatisfaction. Preserving the freedom to exercise clinical judgments on behalf of individual patients, with enough limitations on that freedom to prevent inappropriate care, is a difficult task that is now being approached through the development of practice guidelines<sup>1</sup>(sometimes called practice parameters), often with the hope of avoiding further regulation of medical practice by government or other third parties. Measures of outcome have long been accepted as essential determinants of appropriate care when they are derived from randomized controlled clinical trials testing various clinical interventions. However,
Patient Encounters: The Experience of Disease
Authors: Howard M. Spiro
Journal: JAMA (1989)

I was moved to tears by this book, but that may have been because after two weeks of hectic speaking engagements, I read it all through, sitting quietly in the sun gazing at Long Island Sound on a Saturday, relatively at peace. James Buchanan, an associate professor of philosophy at the University of Akron, who has, so he tells us, taken formal coursework in medicine, worked in physiological laboratories, and been a consultant for ethics review boards, has prepared himself in every way for these stories, all true, which prove a guide to what it means to be sick. To observe or treat a disease is not the same as to suffer from it, he emphasizes. His book provides valuable lessons to physicians.  He divides the book into five parts. The first and longest, Diseases of the Soul, has to do with central nervous system disease; the second, Metabolic Furnaces,
Conference on Tropical Medicine
Authors: S. G. Browne
Journal: BMJ (1967)

appeared disorientated and could not communi- cate.She was quite unable to stand or sit without falling over, and could not hold a cup to feed herself owing to frequent and repeated myoclonic jerks of her head and limbs.No other neurological abnormalities were found and general examination was normal.Lumbar puncture revealed no abnormality.Twenty-four hours after admission she was perfectly well.
Prescribing of Benzodiazepines
Authors: Scott D. Jones
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The article entitled "Benzodiazepine Prescribing in a Family Medicine Center" by Jeffrey D. Hasday, MD, and Fred E. Karch, MD (1981;246:1321), is helpful in elucidating some of the factors influencing the prescription of benzodiazepines and other minor tranquilizers to patients. I wish to emphasize, however, that the benzodiazepines are a diverse group of compounds. Thus, while it is important to maintain a patient on the lowest dose and a limited daily regimen for a number of reasons, the statement by the authors that it is a "good practice considering the altered pharmacokinetics and pharmacodynamics of benzodiazepines in the elderly" is not necessarily true. This statement is true with respect to chlordiazepoxide and the clinically important metabolite common to diazepam, prazepam and clorazepate, or nordiazepam.<sup>1,2</sup>However, oxazepam and lorazepam do not appear to have appreciably altered pharmacokinetics and pharmacodynamics in the elderly.<sup>3,4</sup>Therefore, when an antianxiety
868 EVALUATION OF THE IMMUNOSTIMULATORY ACTIONS OF THE TLR7 AGONIST SM-360320 IN EX VIVO ASSAYS IN THE BLOOD OF HCV PATIENTS AND HEALTHY DONORS
Authors: S. Barker, H. Perkins, R. Bannister, K. Gore, C. Laxton, D. Hamilton, T. Corey, M. Fidock, M. Westby, T. Parkinson, A. Semper, W. Rosenberg
Journal: Journal of Hepatology (2009)
Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed αβ T-cell progenitors
Authors: Julie S. Yuan, Joanne B. Tan, Ioana Visan, Irina R. Matei, Peter Urbanellis, Keli Xu, Jayne S. Danska, Sean E. Egan, Cynthia J. Guidos
Journal: Blood (2010)
Campylobachter fetus Infection in a Patient With Hodgkin's Disease
Authors: Allan N. Krutchik
Journal: JAMA (1977)

To the Editor. —  Campylobacter fetus commonly infects cattle and is transmitted venereally from the testes of bulls. In humans the route of infection is unclear, but man may acquire the disease by ingestion of contaminated water or food. 1 The infection usually occurs in adults with underlying disease such as chronic alcoholism or cardiovascular disease. However, it is uncommon in patients with malignant neoplasms. There have been isolated reports of C fetus infection associated with chronic lymphocytic leukemia, chronic myelogenous leukemia, hepatoma, and non-Hodgkin's lymphoma. 1 To our knowledge, this is the first report of the infection occurring in a patient with Hodgkin's disease.  Report of a Case.—  The patient is a 25-year-old man with a history of Hodgkin's disease, nodular sclerosis, stage IV with pulmonary involvement. Dysuria of two weeks' duration developed and was associated with urethritis and a purulent urethral discharge. Urine and urethral cultures were obtained