Graft-versus-Host Disease in a Liver Transplant Recipient
Authors: Robert H. Collins, Barry Cooper, Afzal Nikaein, Goran Klintmalm, Joseph W. Fay
Journal: Annals of Internal Medicine (1992)

Brief Report1 March 1992Graft-versus-Host Disease in a Liver Transplant RecipientRobert H. Collins Jr., MD, Barry Cooper, MD, Afzal Nikaein, PhD, Goran Klintmalm, MD, PhD, Joseph W. Fay, MDRobert H. Collins Jr., MD, Barry Cooper, MD, Afzal Nikaein, PhD, Goran Klintmalm, MD, PhD, Joseph W. Fay, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-5-391 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe classic requirements for graft-versus-host disease (GVHD) (1) exist in recipients of liver allografts: 1) The donor liver and recipient are histo-incompatible; 2) lymphocytes within the lymph nodes and lymphatics of the donor graft are capable of recognizing the recipient as foreign and reacting to the recipient (for example, hemolysis of ABO-incompatible erythrocytes by allograft-derived antibodies has been well described [2]); and 3) the recipient is receiving post-transplant immunosuppressive therapy that could conceivably prevent recipient immune cells from eliminating anti-recipient donor cells.Despite the presence of immunosuppression, GVHD is believed to be a rare phenomenon in liver transplant patients; few...References1. Billingham R. The biology of graft-versus-host reactions. Harvey Lect. 1966;62:21-78. MedlineGoogle Scholar2. Ramsey G, Nusbacher J, Starzl T, and Lindsay G. Isohemagglutinins of graft origin after ABO-unmatched liver transplantation. N Engl J Med. 1984;311:1167-70. CrossrefMedlineGoogle Scholar3. Burdick J, Vogelsang G, Smith W, Farmer E, Bias W, and Kaufman S. Severe graft-versus-host disease in a liver-transplant recipient. N Engl J Med. 1988;318:689-91. CrossrefMedlineGoogle Scholar4. Marubayashi S, Matsuzaka C, Takeda A, Costa M, and Jamieson N. Fatal generalized acute graft-versus-host disease in a liver transplant recipient. Transplantation. 1990;50:709-11. CrossrefMedlineGoogle Scholar5. Jamieson N, Joysey V, and Friend P. Graft-versus-host disease in solid organ transplantation. Transpl Int. 1991;4:67-71. CrossrefMedlineGoogle Scholar6. Bhaduri B, Tan K, Humphreys S, Williams R, Donaldson P, and Vergani D. Graft-versus-host disease after orthotopic liver transplantation in a child. Transplant Proc. 1990;22:2378-80. MedlineGoogle Scholar7. Thaler M, Shamiss A, Orgad S, Huszar M, Nussinovitch N, and Meissel S. The role of blood from HLA-homozygous donors in fatal transfusion-associated graft-versus-host disease after open-heart surgery. N Engl J Med. 1989;321:25-8. CrossrefMedlineGoogle Scholar8. Kruskall M, Alper C, Awdeh Z, and Yunis E. HLA-homozygous donors and transfusion-associated graft-versus-host disease [Letter]. N Engl J Med. 1990;322:1004-7. CrossrefMedlineGoogle Scholar9. Byers V, Henslee A, Kernan N, Blazer B, Gingrich R, and Phillips G. Use of an anti-pan T-lymphocyte ricin A chain immunotoxin in steroid-resistant acute graft-versus-host disease. Blood. 1990;75:1426-32. CrossrefMedlineGoogle Scholar10. Roberts J, Ascher N, and Lake J. Graft-versus-host disease after liver transplantation in humans: a report of four cases. Hepatology. 1991;14:274-81. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert H. CollinsJr., MD; Barry Cooper, MD; Afzal Nikaein, PhD; Goran Klintmalm, MD, PhD; Joseph W. Fay, MDFrom Baylor University Medical Center, Dallas, Texas. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGraft‐versus‐host disease after pediatric liver transplantation: A diagnostic challengeImproved survival after LTx-associated acute GVHD with mAb therapy targeting IL2RAb and soluble TNFAb: Single-center experience and systematic reviewDermatologic manifestations of solid organ transplantation–associated graft-versus-host disease: A systematic reviewNovel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver TransplantationGraft Versus Host Disease After Liver Transplantation in AdultsAbsence of peripheral blood chimerism in graft-vs-host disease following orthotopic liver transplantation: case report and review of the literatureAcute graft versus host disease after orthotopic liver transplantationGraft-versus-host disease after liver transplantationGraft versus host disease after liver transplantation – a single center experience and review of literatureGraft vs. host disease after liver transplantation: A new approach is neededRecipient and donor factors influence the incidence of graft-vs.-host disease in liver transplant patientsGraft-vs.-host disease in lung and other solid organ transplant recipientsAcute Graft versus Host Disease After Liver Transplantation: Patterns of Lymphocyte ChimerismRash and pancytopenia as initial manifestations of acute graft-versus-host disease after liver transplantationGraft-versus-host disease following living donor liver transplantationMonitoring systemic donor lymphocyte macrochimerism to aid the diagnosis of graftversus-host disease after liver transplantationTreatment of Graft-Versus-Host Disease After Liver Transplantation with Basiliximab Followed by Bowel ResectionGraft-vs-Host Disease After Solid Organ TransplantUnusual onset of chronic graft-versus-host disease after adult living-related liver transplantation from a homozygous donorLiver transplant-associated graft-versus-host diseaseAcute graft-versus-host disease of the lung after liver transplantationSUCCESSFUL OUTCOME OF ACUTE GRAFT-VERSUS-HOST DISEASE IN A LIVER ALLOGRAFT RECIPIENT BY WITHDRAWAL OF IMMUNOSUPPRESSIONMicrochimerism, GVHD, and tolerance in solid organ transplantationHUMAN HERPESVIRUS-6 IN LIVER TRANSPLANT RECIPIENTSRapid method for the analysis of peripheral chimerism in suspected graft-versus-host disease after liver transplantationCutaneous lesions as the presenting sign of acute graft-versus-host disease following liver transplantationPCR confirmation of microchimerism and diagnosis of Graft versus Host Disease after liver transplantationUnusual presentation of graft-versus-host disease in pediatric liver transplant recipients: Evidence of late and recurrent diseaseROLE OF DONOR LEUKOCYTE CHIMERISM IN ESTABLISHING THE ETIOLOGY OF NEUTROPENIA AFTER LIVER TRANSPLANTATION1Successful resolution of severe graft versus host disease after liver transplantation correlating with disappearance of donor DNA form the peripheral bloodPersistent Hypersplenism Early After Liver TransplantLETHAL GRAFT-VERSUS-HOST DISEASE AFTER SIMULTANEOUS KIDNEY-PANCREAS TRANSPLANTATIONTHE NEW AGE OF LIVER TRANSPLANTATIONDetection of circulating donor deoxyribonucleic acid by microsatellite analysis in a liver transplant recipientFEVER IN THE SOLID ORGAN TRANSPLANT PATIENTAplastic anemia after liver transplantationHLA Homozygosity and Shared HLA Haplotypes in the Development of Transfusion-Associated Graft-Versus-Host DiseaseCurrent thoughts on the pathogenesis of graft versus host disease.Graft-versus-host disease after liver transplantationDonor-Derived Long-Term Multilineage Hematopoiesis in a Liver-Transplant RecipientGraft-versus-Host Disease Associated with Transfusion of Blood from Unrelated HLA-Homozygous DonorsGraft-versus-Host Disease and Liver TransplantationAlex M. DePaoli, MD, Jacob Bitran, MD 1 March 1992Volume 116, Issue 5 Page: 391-392 Keywords Bone marrow transplantation Cells Graft vs host disease Immunology Immunosuppressives Liver diseases Liver transplantation Lymph nodes Lymphocytes Surgery ePublished: 1 December 2008 Issue Published: 1 March 1992 PDF downloadLoading ...