Postpartum Thrombotic Thrombocytopenic Purpura (TTP) Complicating Pregnancy-Associated Immune Thrombocytopenic Purpura (ITP)
Authors: Martee Olenich
Journal: Annals of Internal Medicine (1994)

Brief Reports15 May 1994Postpartum Thrombotic Thrombocytopenic Purpura (TTP) Complicating Pregnancy-Associated Immune Thrombocytopenic Purpura (ITP)Martee Olenich, MD and Elaine Schattner, MDMartee Olenich, MDFrom The New York Hospital-Cornell Medical Center, New York, New York.Search for more papers by this author and Elaine Schattner, MDFrom The New York Hospital-Cornell Medical Center, New York, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-10-199405150-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Although immune thrombocytopenic purpura in pregnancy is common, thrombotic thrombocytopenic purpura is rare and requires aggressive therapy. We report the case of a young pregnant woman with refractory immune thrombocytopenic purpura who developed postpartum thrombotic thrombocytopenic purpura and was successfully treated with plasmapheresis. The case emphasizes the importance of reviewing peripheral blood smears for evaluation of thrombocytopenia even when the diagnosis is felt to be clear. The coexistence of these two disorders has not been previously reported in the English-language literature.Case ReportA 15-year-old girl, gravida 1, para 0, presented at 11 weeks of pregnancy with hyperemesis gravidarum. A ...References1. Burrows RF, Kelton JG. Thrombocytopenia at delivery: a prospective survey of 6715 deliveries. Am J Obstet Gynecol. 1990; 162:731-4. Google Scholar2. Weiner CP. Thrombotic microangiopathy in pregnancy and the postpartum period. Semin Hematol. 1987; 24:119-29. Google Scholar3. McCrae KR, Samuels P, Schreiber AD. Pregnancy-associated thrombocytopenia: pathogenesis and management. Blood. 1992; 80:2697-714. Google Scholar4. Schwartz ML, Brenner WE. The obfuscation of eclampsia by thrombotic thrombocytopenic purpura. Am J Obstet Gynecol. 1978; 131:18-24. Google Scholar5. Schwartz ML, Brenner W. Severe preeclampsia with persistent postpartum hemolysis and thrombocytopenia treated by plasmapheresis. Obstet Gynecol. 1985; 65:53S-55S. Google Scholar Author, Article, and Disclosure InformationAffiliations: From The New York Hospital-Cornell Medical Center, New York, New York.Corresponding Author: Elaine Schattner, MD, Division of Hematology-Oncology, Room C-606, The New York Hospital-Cornell Medical Center, 525 East 68th Street, New York, NY 10021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySequential occurrence of thrombotic thrombocytopenic purpura, essential thrombocythemia, and idiopathic thrombocytopenic purpura in a 42-year-old African-American woman: a case report and review of the literatureRecurrent ischemic stroke in a patient with idiopathic thrombocytopenic purpuraThrombotic thrombocytopenic purpura in 166 pregnancies: 1955-2006Imitators of Severe PreeclampsiaImitators of severe pre-eclampsia/eclampsiaNine Years of Cascade Filtration for Thrombotic Thrombocytopenic PurpuraIdiopathic thrombocytopenic purpura: Pathophysiology and managementFour patients with both thrombotic thrombocytopenic purpura and autoimmune thrombocytopenic purpura: The concept of a mixed immune thrombocytopenia syndrome and indications for plasma exchange 15 May 1994Volume 120, Issue 10Page: 845-847KeywordsBloodBlood cellsHemoglobinIdiopathic thrombocytopenic purpuraInfantsLactate dehydrogenasePlateletsPregnancySteroidsThrombotic thrombocytopenic purpura Issue Published: 15 May 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...