tbuckley/cabot-search huggingface dataset:
Insulin-like growth factor binding protein-1 (IGFBP-1) targets both the insulin-like growth factor (IGF) and integrin pathways for the inhibition of breast cancer cell motility.
Authors: YH Ibrahim, J Hartel, K La Parra, D Yee
Journal: Cancer Research (2009)

Abstract Abstract #402 The insulin-like growth factor (IGF) system is a relevant therapeutic target for the treatment of breast cancer. Besides receptor targeted therapies, inhibition of ligand-receptor interactions by IGF-sequestering agents such as IGF binding proteins has also proven efficacious. We have used IGF binding protein (IGFBP-1) to neutralize IGF action. This binding protein both binds IGF-I and binds integrins through a RGD sequence and blocks IGF-I induced proliferation and motility. To examine the functional motifs in IGFBP-1, we studied breast cancer cells and examined IGF-induced signaling and biology after exposure to native recombinant human IGFBP-1 (rhIGFBP-1), reduced rhIGFBP-1, and an RGD mutant (Trp-Gly-Asp, WGD) rhIGFBP-1. Native and WGD IGFBP-1 retained IGF-I binding affinity, whereas reduced IGFBP-1 lost ligand binding as confirmed by western ligand blot. Chronic (&amp;gt;3 hour) 80nM rhIGFBP-1 treatment abrogated paxillin phosphorylation and initiated MAPK activation in an IGF-independent manner, and inhibited basal motility and adhesion to fibronectin. While 80nM native rhIGFBP-1 abolished IGF-induced IRS, PKB/Akt and ERK phosphorylation, 80nM reduced rhIGFBP-1 only inhibited IGF-induced PKB/Akt phosphorylation. rhIGFBP-1 inhibited IGF-induced motility, adhesion to fibronectin and anchorage independent growth at IC50 40-80nM. In contrast, efficacy of reduced IGFBP-1 ranged between 80-160nM. Both the IGF-binding and the integrin-binding mechanisms of action of IGFBP-1 were inhibitory to IGF-induced integrin functions. In contrast, IGF-neutralization (but not integrin effects) was required for the inhibition of biology of breast cancer cells in monolayer. Therefore, this study demonstrates that IGFBP-1 has two distinct functional motifs that contribute to the inhibition of breast cancer basal and IGF-induced functions, and that the integrin and IGF-binding motifs of IGFBP-1 cooperatively inhibit IGF-action. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 402.
Mechanism and Kinetics of Factor VIII Inactivation: Study With an IgG4 Monoclonal Antibody Derived From a Hemophilia A Patient With Inhibitor
Authors: Marc G. Jacquemin, Benoı̂t G. Desqueper, Abdellah Benhida, Luc Vander Elst, Marc F. Hoylaerts, Marleen Bakkus, Kris Thielemans, Jef Arnout, Kathelijne Peerlinck, Jean Guy G. Gilles, Jos Vermylen, Jean-Marie R. Saint-Remy
Journal: Blood (1998)
Homer Proteins Regulate Sensitivity to Cocaine
Authors: Karen K. Szumlinski, Marlin H. Dehoff, Shin H. Kang, Kelly A. Frys, Kevin D. Lominac, Matthias Klugmann, Jason Rohrer, William Griffin, Shigenobu Toda, Nicolas P. Champtiaux, Thomas Berry, Jian C. Tu, Stephanie E. Shealy, Matthew J. During, Lawrence D. Middaugh, Paul F. Worley, Peter W. Kalivas
Journal: Neuron (2004)
Pyrethroid Pesticide Exposure and Parental Report of Learning Disability and Attention Deficit/Hyperactivity Disorder in U.S. Children: NHANES 1999–2002
Authors: Lesliam Quirós-Alcalá, Suril Mehta, Brenda Eskenazi
Journal: Environmental Health Perspectives (2014)

Use of pyrethroid insecticides has increased dramatically over the past decade; however, data on their potential health effects, particularly on children, are limited.We examined the cross-sectional association between postnatal pyrethroid exposure and parental report of learning disability (LD) and attention deficit/hyperactivity disorder (ADHD) in children 6-15 years of age.Using logistic regression, we estimated associations of urinary metabolites of pyrethroid insecticides with parent-reported LD, ADHD, and both LD and ADHD in 1,659-1,680 children participating in the National Health and Nutrition Examination Survey (1999-2002).The prevalence rates of parent-reported LD, ADHD, and both LD and ADHD were 12.7%, 10.0%, and 5.4%, respectively. Metabolite detection frequencies for 3-PBA [3-phenoxybenzoic acid], cis-DCCA [cis-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid], and trans-DCCA [trans-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid] were 77.1%, 35.6%, and 33.9%, respectively. The geometric mean 3-PBA concentration was 0.32 μg/L (median = 0.31 μg/L; interquartile rage = 0.10-0.89 μg/L). cis- and trans-DCCA 75th-percentile concentrations were 0.21 μg/L and 0.68 μg/L, respectively. Log10-transformed 3-PBA concentrations were associated with adjusted odds ratios (ORs) of 1.18 (95% CI: 0.92, 1.51) for parent-reported LD, 1.16 (95% CI: 0.85, 1.58) for ADHD, and 1.45 (95% CI: 0.92, 2.27) for both LD and ADHD. Adjusted ORs remained nonsignificant and decreased after controlling for creatinine and other environmental chemicals previously linked to altered neurodevelopment. Similarly, no significant associations were observed for cis- and trans-DCCA.Postnatal pyrethroid exposure was not associated with parental report of LD and/or ADHD. Given the widespread and increasing use of pyrethroids, future research should evaluate exposures at current levels, particularly during critical windows of brain development.
Cystic Fibrosis
Authors: Beryl J. Rosenstein, Terry S. Langbaum, Ellen Gordes, Saul W. Brusilow
Journal: JAMA (1978)

The sweat test is the only practical and reliable laboratory test for confirmation of the diagnosis of cystic fibrosis. Among 234 patients referred to The Johns Hopkins Hospital for sweat testing, 62 had had a previous test; 29 tests had been reported as negative, and 33 tests had been reported as positive. Results of quantitative pilocarpine-iontophoresis sweat tests at this center led to a change in diagnosis in 27 (43.5%) of these 62 patients. Most of the errors were false-positive.
REPAIR OF DURAL AND BRAIN DEFECTS BY FREE FAT AND FASCIAL TRANSPLANTS
Authors: ALBERT E. HALSTEAD
Journal: JAMA (1924)

The repair of defects of the dura mater following trauma or the extirpation of brain tumors is sometimes a difficult surgical problem. One of the first questions to be decided is what material will be used for the plastic operation. The dura is a strong, fibrous membrane almost avascular, lined by a layer of cells termed endothelial.<sup>1</sup>It lies in contact with the leptomeninges save where it is separated by cerebrospinal fluid. In selecting substitutes for the dura, in repair of its defect, we must find a tissue that will fulfil several requirements. It must be strong and unyielding to resist intracranial pressure. It must be capable of forming a tight union with the surrounding intact dura. It must, if possible, be of such a nature as not to coalesce with the brain or leptomeninges. If autoplastic material is used, its viability must be assured. In line with present
Role of AT1 receptors in the resetting of the baroreflex control of heart rate by angiotensin II in the rabbit.
Authors: J Wong, L Chou, I A Reid
Journal: Journal of Clinical Investigation (1993)

Angiotensin II (Ang II) resets the baroreflex control of heart rate to a higher blood pressure. This action is apparently mediated via Ang II receptors in the area postrema, but it is not known if these are of the AT1 or AT2 subtype. In the present study the effects of losartan, a selective AT1 receptor antagonist, and PD 123319, a selective AT2 antagonist, on the cardiac baroreflex response to Ang II were investigated in conscious rabbits with chronically implanted arterial and venous catheters. Baroreflex curves were generated with intravenous infusions of phenylephrine and nitroprusside (2.6-25 micrograms/kg per min) and analyzed using a four-parameter logistic model to yield their upper and lower plateaus, arterial pressure at the midpoint of the heart rate range (BP50), and slope coefficient. From these four parameters, the gain and range of the baroreflex were calculated. Background intravenous infusion of Ang II at 10 ng/kg per min increased mean arterial pressure by 17 mmHg but did not change heart rate. Ang II shifted the baroreflex curve to the right as indicated by an increase in BP50 from 70.9 +/- 2.0 to 89.3 +/- 2.7 mmHg (P < 0.05), but did not change baroreflex gain significantly. Ang II did not alter the upper plateau of the baroreflex, but decreased the lower plateau from 119.4 +/- 10.3 to 73.6 +/- 11.5 beats per minute (bpm) (P < 0.05), extending the heart rate range by 52.5 bpm. Pretreatment with losartan completely abolished the pressor and cardiac baroreflex responses to Ang II. In contrast, PD 123319 had no effect on these responses. Administration of losartan alone to block endogenous Ang II shifted the baroreflex curve to the left as indicated by a decrease in BP50 from 71.2 +/- 2.7 to 64.7 +/- 2.5 mmHg (P < 0.05). These results demonstrate that the resetting of the baroreflex control of heart rate by Ang II is mediated by AT1 receptors, and that basal levels of endogenous Ang II exert a tonic action on the cardiac baroreflex to increase the setpoint around which the baroreflex regulates heart rate.
Amino acid alterations in fibronectin binding protein A (FnBPA) and bacterial genotype are associated with cardiac device related infection in Staphylococcus aureus bacteraemia
Authors: Nina J Hos, Siegbert Rieg, Winfried V Kern, Daniel Jonas, Vance G Fowler, Paul G Higgins, Harald Seifert, Achim J Kaasch
Journal: Journal of Infection (2014)
Nontraumatic Myoglobinuria as a Cause of Acute Tubular Necrosis.
Authors: R. A. Grossman
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Nontraumatic Myoglobinuria as a Cause of Acute Tubular Necrosis.R. A. Grossman, M.D., R. W. Hamilton, M.D., B. M. Morse, M.D., A. S. Penn, M.D., Martin Goldberg, M.D., F.A.C.P.R. A. Grossman, M.D.Search for more papers by this author, R. W. Hamilton, M.D.Search for more papers by this author, B. M. Morse, M.D.Search for more papers by this author, A. S. Penn, M.D.Search for more papers by this author, Martin Goldberg, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-827_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past 3 years we have observed 15 cases in which myoglobinuria, in the absence of surgery or trauma, was the sole identifiable cause of ensuing acute tubular necrosis. Myoglobin, positively identified by acrylamide gel electrophoresis and immunodiffusion, was found in the urine of all patients and in the serum of eight patients. Gross pigmenturia was often not present; but pigmented granular casts were always seen in the urine sediment. A positive ortho-toluidine test (Hematest) of the urine, in the absence of red cells, microscopically, was a frequent finding. Unique features included a strikingly elevated serum Phosphokinase value; rapidly... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 827-827KeywordsCellsGel electrophoresisNecrosisTrauma surgeryUrine Issue Published: 1 May 1973 PDF downloadLoading ...
Pressure Ulcers Preventable, Say Many Clinicians
Authors: Virginia Cowart
Journal: JAMA (1987)

PRESSURE ULCERS, the scourge of immobilized patients, can usually be prevented. That is the view of many physicians who attended the first national symposium on the subject recently. These include a University of Chicago dermatologist, who notes that up to 7% of hospitalized patients have pressure ulcers, as do an estimated 15% to 20% of patients in nursing homes. Moreover, says Allan L. Lorincz, MD, patients who already have pressure ulcers can be successfully treated. Lorincz is professor and head of the section of dermatology and codirector of the Wound Healing Research Center of the University of Chicago Hospitals and Clinics. It is estimated that between 1.5 million and 3 million persons in the United States have pressure ulcers. Lorincz contends there is a lack of interest in the problem that he attributes, in part, to "the attitude that patients who develop pressure sores are not very salvageable in terms
Anticentromere antibody: an immunological marker of a subset of systemic sclerosis
Authors: T.P. CHORZELSKI, S. JABLONSKA, E.H. BEUTNER, M. BLASZCZYK, M. JARZABEK-CHORZELSKA, D. KENCKA, S. KRASNY, V. KUMAR, A. TCHORZEWSKA
Journal: British Journal of Dermatology (1985)

Our clinical and immunological studies of 114 cases of systemic sclerosis, 54 of Raynaud's disease and 46 of other connective tissue diseases, centered on the diagnostic and prognostic significance of anticentromere antibodies (ACA). The ACA occurred in 21 of 84 patients with acrosclerosis, in four of 54 patients with Raynaud's disease but in none of 30 patients with diffuse scleroderma or transitional form, acrosclerosis‐diffuse scleroderma, or 46 cases of other connective tissue diseases. The ACA‐positive patients had no contracture or immobilization of the fingers, the indurations and/or indurative oedema were confined to fingers and usually no other types of ANA were detected. However, systemic involvement and the course of the disease were comparable in ACA‐negative and ACA‐positive acrosclerosis patients. The studies indicate that there is a subset of acrosclerosis with minimal indurations confined to the fingers, and ACA appears to be its serological marker. We propose to use the term CREST for this subset, which to date has not been exactly defined and is regarded by some authors as synonymous with acrosclerosis.
NITRIC OXIDE DONATION FROM THE CINOD NAPROXCINOD COUNTERACTS CYCLOOXYGENASE INHIBITION-DEPENDENT CONTRACTION IN HUMAN MAMMARY ARTERIES
Authors: Manlio Bolla, Alessandra Poggi, Barbara Vergani, Guido Gelpi, Julio Padron, Daniela Miglietta
Journal: Journal of the American College of Cardiology (2010)
The Effect of Stem Cell Mobilization by Granulocyte-Colony Stimulating Factor on Neointimal Hyperplasia and Endothelial Healing After Vascular Injury With Bare-Metal Versus Paclitaxel-Eluting Stents
Authors: Hyun-Jai Cho, Tae-Youn Kim, Hyun-Ju Cho, Kyung-Woo Park, Shu-Ying Zhang, Ji-Hyun Kim, Sung-Hwan Kim, Joo-Yong Hahn, Hyun-Jae Kang, Young-Bae Park, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2006)
Predictors of cardiovascular events in patients with type 2 diabetic nephropathy and hypertension: A case for albuminuria
Authors: Nagesh S. Anavekar, Daniel J. Gans, Tomas Berl, Richard D. Rohde, William Cooper, Amitabha Bhaumik, Lawrence G. Hunsicker, Jean-Lucien Rouleau, Julia B. Lewis, Clive Rosendorff, Jerome G. Porush, Paul L. Drury, Enric Esmatjes, Itamar Raz, Phillippe Vanhille, Franceso Locatelli, Samuel Goldhaber, Edmund J. Lewis, Marc A. Pfeffer
Journal: Kidney International (2004)
Rhabdomyosarcoma Producing Respiratory Obstruction
Authors: Carl Pochedly
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Embryonal rhabdomyosarcomas occur with relative frequency in the head and neck of young children. They most commonly involve the orbit, nasal sinuses, and middle ear. About 30% of head and neck rhabdomyosarcomas have their origin in intraoral or pharyngeal structures.<sup>1</sup>The greatest number involve the nasopharynx, comprising one third of the cases reported. The tongue, palate, and uvula are next in order of frequency. But on rare occasions rhabdomyosarcomas may occur in the hypopharynx and cause acute airway obstruction. <h3>Report of a Case.—</h3> A 21/2-year-old girl was brought to the emergency room of the Nassau County Medical Center in acute respiratory distress. The child had a two-week history of upper respiratory tract infection, which was treated with an antibiotic with no improvement. Two days before admission, she had an acute episode of dyspnea and cyanosis. On the day of admission, the patient developed another episode of
Episodic Nucleotide Substitutions in Seasonal Influenza Virus H3N2 Can Be Explained by Stochastic Genealogical Process without Positive Selection
Authors: Kangchon Kim, Yuseob Kim
Journal: Molecular Biology and Evolution (2014)

Nucleotide substitutions in the HA1 domain of seasonal influenza virus H3N2 occur in temporal clusters, which was interpreted as a result of recurrent selective sweeps underlying antigenic drift. However, classical theory by Watterson suggests that episodic substitutions are mainly due to stochastic genealogy combined with unique genetic structure of influenza virus: High mutation rate over a nonrecombining viral segment. This explains why even larger variance in the number of allelic fixations per year is observed in nonantigenic gene segments of H3N2 than in antigenic (hemagglutinin and neuraminidase) segments. Using simulation, we confirm that allelic substitutions at nonrecombining segments with high mutation rate become temporally clustered without selection. We conclude that temporal clustering of fixations, as it is primarily caused by inherent randomness in genealogical process at linked sites, cannot be used as an evidence of positive selection in the H3N2 population. This effect of linkage and high mutation rate should be carefully considered in analyzing the genomic patterns of allelic substitutions in asexually reproducing systems in general.
Tube Feeding in Patients With Advanced Dementia—Reply
Authors: Thomas E. Finucane, Colleen Christmas
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
995. Effect OF BCL-2 Overexpression on Plasmodium Infection
Authors: Francisco Martinez-F, Jose Luis Ventura, Luis F. Covarrubias, Alejandro Zentella-D, Martha Legorreta-H
Journal: Molecular Therapy (2005)

Introduction: Malaria is the most common parasitic disease in the world. Every year, 1 to 1.5 million people died from it. During the early infection, the progressive high level of parasitaemia is associated to immunosuppression state of the host. Additionally, an increased level of apoptotic lymphocytes is observed at the same time. Based on this described findings, we are exploring the bcl-2 over-expression in the spleen cells and their effect on the infection course.
Low Incidence of Acute Urinary Retention in the General Male Population: The Triumph Project
Authors: K.M.C. Verhamme, J.P. Dieleman, M.A.M. van Wijk, J.L.H.R. Bosch, B.H.Ch. Stricker, M.C.J.M. Sturkenboom
Journal: European Urology (2004)
Dipyridamole directly inhibits vascular smooth muscle cell proliferation in vitro and in vivo: Implications in the treatment of restenosis after angioplasty
Authors: Jai Pal Singh, Kimberly J. Rothfuss, Todd R. Wiernicki, William B. Lacefield, L. Kurtz, Raymond F. Brown, Kellie A. Brune, Dianna Bailey, Gregory P. Dubé
Journal: Journal of the American College of Cardiology (1994)
Abstract 1976: Targeting the PP2A tumor suppressor for the treatment of human pancreatic cancer.
Authors: Amy Farrell, Colin Daniel, Zhiping Wang, Brittany Allen-Petersen, Dale Christensen, Brett Sheppard, Charles D. Lopez, Rosalie Sears
Journal: Cancer Research (2013)

Abstract Pancreatic cancer is a disease with a high rate of mortality, as it is generally diagnosed in the advanced stages when few effective treatments are available. Given the clinical aggressivity of this disease and the lack of good treatment options, the development of new therapeutic agents for the treatment of pancreatic cancer is of the upmost importance. Recent reports have suggested that disruption of several key signal transduction pathways is important for the development of pancreatic cancer. Many of these pathways are negatively regulated by PP2A, a phosphatase that plays a role in many cellular processes, and whose inhibition is essential for cell transformation. PP2A inhibition can occur through inactivation by viral oncogenes, mutation of specific subunits, or by overexpression of endogenous inhibitors, including SET (also known as I2PP2A) and Cellular Inhibitor of PP2A (CIP2A). Here, we show that SET and CIP2A are frequently overexpressed in human pancreatic cancer cells and primary patient samples. This overexpression results in decreased PP2A activity, and overexpression and stabilization of a key PP2A target, c-Myc. Knockdown of SET or CIP2A increases PP2A activity and reduces tumorigenic potential. Furthermore, inhibition of SET using a peptide mimetic (OP449) in pancreatic cancer cell lines increases PP2A activity, reduces migration and invasion, and decreases tumorigenic potential. Thus, antagonizing SET and CIP2A could be an innovative approach for the treatment of human pancreatic cancer. Citation Format: Amy Farrell, Colin Daniel, Zhiping Wang, Brittany Allen-Petersen, Dale Christensen, Brett Sheppard, Charles D. Lopez, Rosalie Sears. Targeting the PP2A tumor suppressor for the treatment of human pancreatic cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1976. doi:10.1158/1538-7445.AM2013-1976
On dying and dyeing
Authors: Douglas Kamerow
Journal: BMJ (2007)

The risk of suicide associated with antidepressant treatment has gotten a lot of attention recently. Annalisa Rubino and colleagues analyzed data from more than 200 000 British general practice patients in a retrospective cohort study (doi: 10.1136/bmj.39041.445104.BE) of suicides in patients on antidepressants. After statistical adjustments for potential confounding characteristics, patients who had taken venlafaxine were significantly more likely to have died by suicide than patients on citalopram, fluoxetine, or dothiepin. The authors acknowledge, however, that they couldn't control for everything, and that patients taking venlafaxine had more suicide risk factors …
Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells
Authors: Weiqiang Li, Lihua Huang, Wanyi Lin, Qiong Ke, Rui Chen, Xingqiang Lai, Xiaoyu Wang, Jifeng Zhang, Meihua Jiang, Weijun Huang, Tao Wang, Xuesong Yang, Yuan Chen, Wu Song, Andy Peng Xiang
Journal: Biomaterials (2014)
SARS-Associated Coronavirus Quasispecies in Individual Patients
Authors: Dongping Xu, Zheng Zhang, Fu Sheng Wang
Journal: New England Journal of Medicine (2004)

To the Editor: Quasispecies are known in RNA viruses such as hepatitis C virus and human immunodeficiency virus.1 Owing to poor fidelity of RNA polymerases, RNA-virus populations typically contain genetic variants that form a heterogeneous virus pool. The severe acute respiratory syndrome (SARS)–associated coronavirus, as a newly identified RNA virus,2 however, has been reported with relatively limited variations,3,4 and no published data have recorded the existence of quasispecies. During the SARS outbreak from March to June in 2003, 132 patients with SARS were treated in our unit, including those with the first cluster of cases in the Beijing, China, . . .