tbuckley/cabot-search huggingface dataset:
Integration of DSM-III and ICD-8 to Be Used in a Consultation-Liaison Psychiatric Service
Authors: Loldrup Poulsen, F. Zierau, L. Eplov, P.W. Jepsen, M. Kastrup, B. Kijne, S. Rasmussen, M. Stubgaard, P. Bech
Journal: Psychotherapy and Psychosomatics (1987)

In 1983 a total of 405 patients received psychiatric supervision in somatic departments in the general hospital. At this supervision, these patients were registered by means of a five-axial diagnostic coding according to the DMS III principle, and this was combined with a quantitative global assessment of the severity of the condition. Reliability testing was undertaken by five supervising physicians with a total of 15 patients. The total number of supervisions constituted one supervision per somatic bed per annum. Women were overrepresented, and medical departments made the greatest use of psychiatric supervision. Reactive conditions dominated parallel with a high relative incidence of alcohol-related conditions. In patients with diagnoses of psychoses, only slight to moderate psychiatric symptoms were encountered. This held true also for personality deviations. 50% of the patients had experienced significant psychosocial stress, but 10 % of these were diagnosed as having non-reactive psychoses. 52% of the patients had moderate to pronounced disturbances of social function. Half of the patients supervised in this manner could be investigated or treated in the referrring departments. Approximately half of the patients in whom referral to private psychiatric specialists was made did not keep these appointments. Reliability testing in the material shows the employability of the diagnostic armamentarium. All in all, the investigation suggests that extension of the liaison psychiatric service in somatic departments would result in a relative increase in the number of patients who could be treated in the referring department and an increase in the number of psychiatric conditions diagnosed. Establishment of a psychiatric outpatient clinic in the somatic environment appears to be indicated.
Man's Image in Medicine and Anthropology.
Authors: Marjorie C. Meehan
Journal: JAMA (1963)

Interdisciplinary conferences are fashionable. The New York Academy of Medicine organized this one, held in 1961. Undoubtedly, the contributors were chosen to present a diversity of viewpoints on a shared theme—the relationship of medicine and anthropoly. As often happens, the diversity was achieved, not only in viewpoint, but in subject matter, so that we have an assortment of essays on various topics, most of them worth reading, but unfortunately not adding up to a truly coherent whole. The opening paper, designated as theme of the volume, is by Whitehorn. He discusses several theories of man, disease, and therapy, emphasizing the importance of language and the leadership role of the physician. Other authors present interesting descriptions of magic, religion, and medical theory and practice in different primitive groups. A sophisticated modern exposition of the doctrine of the "noble savage" is offered by Diamond, who claims that "our illness springs from the
Arteriosclerosis in normal and von Willebrand pigs: long-term prospective study and aortic transplantation study.
Authors: V Fuster, D N Fass, M P Kaye, M Josa, A R Zinsmeister, E J Bowie
Journal: Circulation Research (1982)

In a long-term prospective study, five normal control pigs and five pigs with homozygous von Willebrand's disease received a nonfatty diet from age 3 months to 4 years; then the aortas were analyzed. The fibrous arteriosclerotic plaques in the distal abdominal aortic region involved an average of 28% of the surface area in control pigs and only 7% of the surface area in pigs with von Willebrand's disease (P less than 0.01). In a subsequent study of 3-month-old pigs, the distal abdominal aortic segments from nine normal pigs were cross-transplanted with segments from nine other normal pigs (control study), and aortic segments from four normal pigs were transplanted into four host pigs with von Willebrand's disease (exchange study). All pigs received a 2% cholesterol diet for up to 6 months; then the transplanted aortic segments were analyzed. The donor normal aortic segments in the host normal pigs developed arteriosclerosis that involved an average of 20% of the surface; the endothelial fluorescent pattern of von Willebrand factor was identified. In contrast, the donor normal aortic segments in the host pigs with von Willebrand's disease had arteriosclerosis that involved an average of only 4% of the surface (P less than 0.01); the endothelial cell von Willebrand factor was not identified. The long-term prospective study indicates that pigs with von Willebrand's disease are resistant to the development of spontaneous arteriosclerosis. The aortic transplantation data are compatible with the hypothesis that the absence of von Willebrand factor in pigs with von Willebrand's disease may cause impairment of platelet-arterial wall interaction and resistance to arteriosclerosis.
Hepatobiliary Scintigraphy in Pediatric Liver Transplant Recipients
Authors: MICHAEL J. GELFAND, HOWARD S. SMITH, FREDERICK C. RYCKMAN, WILLIAM F. BALISTRERI, BONNY SPECKER, KATHLEEN H. CARON, SUSAN H. PEDERSEN
Journal: Clinical Nuclear Medicine (1992)

The clinical usefulness of hepatobiliary scintigraphy was evaluated in pediatric liver transplant recipients. One hundred fifteen hepatobiliary scintigraphic studies were performed in 30 patients who received 22 whole liver and 16 segmental grafts. Parameters that were useful in predicting an adverse outcome were failure to visualize excreted radiopharmaceutical at or beyond the biliary anastomosis on a study performed within 24 hours after transplant, and persistent or increasing delay in the time of visualization of excreted radiopharmaceutical. Abnormalities of liver uptake and excretion were seen in rejection, but they were also seen in patients who remained well without rejection or parenchymal disease. Significant biliary leaks were identified in the three cases in which they were known to be present. In liver transplant recipients, hepatobiliary imaging is useful in predicting graft survival and identifying biliary leaks.
A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor
Authors: Lisa Gallinaro, Maria Grazia Cattini, Maryta Sztukowska, Roberto Padrini, Francesca Sartorello, Elena Pontara, Antonella Bertomoro, Viviana Daidone, Antonio Pagnan, Alessandra Casonato
Journal: Blood (2008)
Vitamin K1 in Anticoagulant Therapy
Authors: M. Toohey
Journal: BMJ (1954)

DiscussionAccording to Herndon (1927), one of the most characteristic features of Charcot's spine is the disproportion between the severity of the process disclosed by the x-ray film and the slight discomfort and disability complained of by the patient.Usually, clinical evidence of tabes is present.One of the earliest and most constant signs is deformity which is due to bone destruction and subsequent compression of the vertebral body with posterior or lateral displacement.This process is usually limited to one or two vertebrae, and is most often found in the lower dorsal and lumbar spine.The resulting deformity is usually a kyphus with more or less lateral curvature and rotation.There is usually no tender- ness and no muscle spasm.Considerable discomfort is often caused by pressure of the collapsing spine or that of hypertrophic bone formation upon the spinal nerves.These root pains are usually gradual and insidious in onset and of moderate severity.Occasionally, however, they attain considerable intensity, somewhat simulating gastric crises or peptic ulcer pain.The mobility of the spine is little involved unless in cases of excessive destruction.The existence of hereditary Charcot's spine has long been doubted, but it is now an acknowledged fact.Various observers consider many cases of apparent Pott's disease associated with other joint involvement in young children as luetic.It is claimed that radiologically the alternation between sclerosis and rarefaction, bone absorption and bone apposi- tion, is the most striking feature in Charcot's spine.In some cases the destructive, in others the proliferative, changes prevail.Often both are seen concomitantly.The treatment of Charcot's spine consists in general antiluetic therapy and local measures for support and immobil- ization of the spine.Summary Tabetic Charcot's spine probably occurs much more commonly than most textbooks lead us to believe.Severe persistent shooting pains, especially of a girdle distribution, should indicate an x-ray examination of the spine in order to rule out Charcot's disease.Brief case histories of eight tabetics with Charcot's spine are presented.In Case 7 trauma would appear to have been a predisposing factor in the aetiology of the Charcot's spine.We are indebted to Drs.M.
Late Post-traumatic Headache
Authors: J. L. Blonstein
Journal: BMJ (1966)

Sections 5 8 and 59 of the Act are con- veniently quoted by Mrs. Jenkins.'The word " unlawfully " occurs six times, and became the main issue in R. v. Bourne, 1938, which established that abortion can be lawful and unlawful, only the latter being felonious.3That the Act is capable of being misinterpreted by jurists of the eminence of Rupert Cross (in a broadcast talk) is sufficient reason for restating the law, but only increases the need to restate the law accurately.A myth has been created that every time a surgeon performs an abortion the police turn a blind eye, much as they are expected to if he has left his car in the wrong place during the operation.It ought to be under- stood, once and for all, that abortion is an operation like any other operation: the law can neither compel a surgeon to perform it nor, provided his position is ethical, punish him for performing it.What needs changing is not the law but the myth.-Iam, etc.,
MY MOST REWARDING CASE
Authors: D W Barritt
Journal: BMJ (1996)

More than ten years after retirement life continues to have rewards in addition to all the pleasures of a more leisured existence. One of mine has been to become involved in community affairs in our large village. Although not born here I have found myself increasingly trusted and somewhat to my surprise I am now chairman of the council.

At a full meeting of council with 20 members present we begin to consider plans for a major extension to the village hall. One of us is on edge to promote the development. There is …
Abstract 2394: A flexible micro spring array (FMSA) device for the high throughput enrichment of viable CTCs
Authors: Ramdane Harouaka, Ming-Da Zhou, Waleed Khan, Yin-Ting Yeh, Si-Yang Zheng
Journal: Cancer Research (2012)

Abstract The ability of metastatic cancer to release cells that travel through the circulatory system and invade different parts of the body accounts for over 90% of cancer related deaths. The fundamental challenge with detecting these circulating tumor cells (CTCs) in blood samples is the fact that they are so rare, with only a few tumors cells occurring among billions of blood cells. Size based separation has been demonstrated to be an effective method for CTC capture and enrichment. While useful for detection, size based techniques apply concentrated stresses that affect the viability of captured cells. We have incorporated a novel micro spring array to mitigate the stresses experienced by CTCs during filtration to encourage their health and proliferability. The geometric design and filtration pressures have been optimized to maximize capture efficiency, enrichment against leukocytes, and tumor cell viability. The FMSA device can process 7.5 mL of whole blood in approximately 10 minutes, while still preserving cell viability. The successful enrichment and primary culture of viable CTCs from clinical samples will allow unprecedented analysis and genetic testing amounting to a minimally invasive biopsy that may be repeated often to monitor tumor progression. This can also provide the basis for externally testing tumor cell response to a variety of anticancer drugs without having to expose a patient to the unnecessary cost and toxic effects of chemotherapy, thereby improving patient outcomes through the development of personalized treatment plans. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2394. doi:1538-7445.AM2012-2394
Colorectal Cancer Risk
Authors: Hemant K. Roy, Laura K. Bianchi
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Private Patients and Surgical Training
Authors: Robert M. Sade
Journal: JAMA (1977)

Inaccurate and occasionally inflammatory descriptions of the education of surgeons in recent news reports have produced unnecessary anxiety in many patients. For several months after a television program that presented surgical residents as inept students and their teachers as uncertain apologists, anxious patients asked me, "Doctor, will you do the operation?" Before a surgeon-educator can answer this question, he must have a clear concept of the purposes of surgical education and the nature of the surgeon-patient relationship. The nature of surgical treatment focuses a surgeon's education on two paramount skills: surgical technique and judgment of when and when not to operate. Development of both abilities requires progressively increasing responsibility for patient care during the period of surgical training. By the time his residency is completed, a surgeon must be competent to exercise sound surgical judgment, and he must possess adequate technical skill for independent practice. These goals were achieved readily
Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll‐like receptors
Authors: F. Meiler, S. Klunker, M. Zimmermann, C. A. Akdis, M. Akdis
Journal: Allergy (2008)

Allergic diseases are characterized by the activation of the immune system and formation of immunoglobulin (Ig)E antibodies against normally innocuous environmental antigens, whereas IgG4 and IgA represent noninflammatory and blocking antibody isotypes. The T helper 2 (Th2) cells induce and T regulatory (Treg) cells suppress several features of allergic inflammation. Our aim was to investigate the role of allergen-specific T regulatory type 1 (Tr1) cells and CD4(+)CD25(+) Treg cells and toll-like receptors (TLRs) on IgE, IgG4 and IgA production.Germline or productive Ig-transcripts are determined by real-time reverse transcriptase-polymerase chain reaction, secreted Igs are measured by enzyme-linked immunosorbent assay and the frequency of Ig-producing plasma cells is investigated by enzyme-linked immunosorbent spot. Circulating CD4(+)CD25(+) Treg cells and allergen-specific Tr1 cells are used.Both allergen-specific, interleukin-10-secreting Tr1 cells and CD4(+)CD25(+) Treg cells from healthy individuals induced IgG4 and suppressed IgE production in peripheral blood mononuclear cells and purified B-cell cultures. In contrast, induction of IgA production is independent of T-cell help and the role of Tr1 or Treg cells is very limited, whereas it was highly induced by direct B-cell activation via TLR7 and 9.These data suggest that T regulatory cells may contribute to the suppression of allergic diseases by suppression of IgE and induction of IgG4, whereas IgA production is enhanced by B-cell activation via TLR7 and TLR9.
THE EXTENT OF LOCAL DISPERSION OF INFECTIOUS AGENTS AS A FACTOR IN RESISTANCE TO INFECTION
Authors: F. Duran-Reynals
Journal: The Journal of Experimental Medicine (1935)

Progressively decreasing quantities of bacteria of some 20 strains were utilized in experiments upon the effect of dispersing the organisms in the rabbit skin through the agency of an extract of testicle or an invasive staphylococcus. The same was done with 6 strains of filterable viruses. The bacterial lesions were enhanced by spreading when the organisms introduced were above a certain number or quantity (minimal effective concentration) and on the other hand were partially or totally suppressed when their number was less than this. Virulence and minimal effective concentration were observed to be in inverse relationship. The lesions due to the filterable viruses studied were, on the other hand, enhanced by the spreading factor even when the quantity of virus approached the minimal infective dose. This happened irrespective of whether the virus caused severe lesions or slight ones. The highly virulent Pneumococcus Type I, injected into normal rabbits together with the spreading factor, yielded enhanced lesions even at practically its minimal infective dose; but when the resistance of the animal was raised with specific antiserum the lesions were totally suppressed by the experimental dispersion of the bacteria. When such an experiment was repeated on a filterable virus, vaccinia, no suppression took place as a result of the dispersion of the infective agent. The significance of the differences in the bacterial and virus phenomena is discussed.
Engraftment of nonintegrating neural stem cells differentially perturbs cortical activity in a dose-dependent manner
Authors: Tanya N Weerakkody, Tapan P Patel, Cuiyong Yue, Hajime Takano, Hayley C Anderson, David F Meaney, Douglas A Coulter, John H Wolfe
Journal: Molecular Therapy (2013)

Neural stem cell (NSC) therapy represents a potentially powerful approach for gene transfer in the diseased central nervous system. However, transplanted primary, embryonic stem cell- and induced pluripotent stem cell-derived NSCs generate largely undifferentiated progeny. Understanding how physiologically immature cells influence host activity is critical to evaluating the therapeutic utility of NSCs. Earlier inquiries were limited to single-cell recordings and did not address the emergent properties of neuronal ensembles. To interrogate cortical networks post-transplant, we used voltage sensitive dye imaging in mouse neocortical brain slices, which permits high temporal resolution analysis of neural activity. Although moderate NSC engraftment largely preserved host physiology, subtle defects in the activation properties of synaptic inputs were induced. High-density engraftment severely dampened cortical excitability, markedly reducing the amplitude, spatial extent, and velocity of propagating synaptic potentials in layers 2-6. These global effects may be mediated by specific disruptions in excitatory network structure in deep layers. We propose that depletion of endogenous cells in engrafted neocortex contributes to circuit alterations. Our data provide the first evidence that nonintegrating cells cause differential host impairment as a function of engrafted load. Moreover, they emphasize the necessity for efficient differentiation methods and proper controls for engraftment effects that interfere with the benefits of NSC therapy.
Monitoring human lymphocytic DNA-protein cross-links as biomarkers of biologically active doses of chromate.
Authors: M Costa, A Zhitkovich, P Toniolo, E Taioli, T Popov, A Lukanova
Journal: Environmental Health Perspectives (1996)

A simple and sensitive assay for DNA-protein cross-links has been used as a biomarker of chromate exposure and early carcinogenic effects. Pilot studies of DNA-protein cross-links in peripheral blood lymphocytes have been conducted with individuals who had higher exposure to chromate, including welders, and with individuals who had lower levels of exposure such as residents living in a chromium-contaminated area in Jersey City, New Jersey. Studies were also conducted in two Bulgarian cities (Jambol and Burgas) with different levels of air pollution and Cr(VI) exposure and in chrome platers in Bulgaria who had high exposure to chromate. DNA-protein cross-links in U.S. welders and in individuals living in Hudson County, New Jersey around chromium-contaminated areas were significantly higher compared to matched controls. Although blood and urinary levels of chromium were not extensively studied in these populations, we were able to obtain these measurements in the Bulgarian population. Chromium levels in red blood cells of controls living in Burgas were in the order of 1 to 2 ppb chromium, and these individuals had the lowest levels of DNA-protein cross-links. However, the chromium levels in Jambol ranged from about 2 to 7 ppb in red blood cells of city residents to about 22 ppb in chrome platers. DNA-protein cross-links were saturated at about 7 to 8 ppb chromium in the red blood cells, and cross-links correlated well only with chromium levels in red blood cells. Urinary chromium levels did not correlate well with either DNA-protein cross-links or chromium levels in with red blood cells.
(13) Pterygium: deformity of finger nails in association with generalized psoriasis
Authors: J.D. Kirby, D.D. Munro
Journal: British Journal of Dermatology (1974)

Journal Article (13) Pterygium: deformity of finger nails in association with generalized psoriasis Get access J.D. Kirby, J.D. Kirby St Bartholomew's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar D.D. Munro D.D. Munro St Bartholomew's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue s10, 1 July 1974, Pages 57–59, https://doi.org/10.1111/j.1365-2133.1974.tb12516.x Published: 01 July 1974
Physical activity and health
Authors: K. E Powell, M. Pratt
Journal: BMJ (1996)

attractive to private hospital groups than to the pharmaceutical industry, but, as in the United States, there would be scope for mergers and alliances.In primary care, contracting for services has hardly begun, but it would enable more quality control than in the present system and it would be more open to competition from alternative providers.Moreover, general practitioners will increasingly be looking for alternative ways of financing their premises.Already there are pharmacies in health centres owned by general practitioners: how long before we see general practitioners in premises owned by the private sector, and then the private provider contracting for the services?With government and health authorities under financial pressure and drug companies and private providers looking for commercial opportunities, increased cooperation is likely' between the public and private sectors.To prevent the pharmaceutical industry from becoming overdominant, the 1 Macara A. BMA rejects trend towards American style managed care.London:
STUDIES ON RENIN: THE DURATION OF THE PRESSOR EFFECT OF LARGE DOSES IN CONSCIOUS NORMAL AND RENALLY ABNORMAL DOGS. OBSERVATIONS ON ANESTHETIZED AND UREMIC DOGS, AND THE ANAPHYLACTIC AND PATHOLOGICAL EFFECTS OF PIG RENIN
Authors: Louis Leiter, Lillian Eichelberger, Michael Roma
Journal: Journal of Clinical Investigation (1943)