tbuckley/cabot-search huggingface dataset:
Serum Triiodothyronine and Thyroxine in the Neonate and the Acute Increases in These Hormones Following Delivery
Authors: J. Abuid, D. A. Stinson, P. R. Larsen
Journal: Journal of Clinical Investigation (1973)

Low triiodothyronine (T3) and high normal thyroxine (T4) concentrations are present in cord sera from full term infants. To examine this phenomenon further, radioimmunoassay of T3 and T4 was carried out in paired maternal and cord sera as well as capillary sera from neonates at different intervals after delivery. Free T3 and free T4 concentrations were also estiamted in cord and maternal sera by equilibrium dialysis. In 12 paired specimens, the T3 concentration in cord sera was significantly lower than the maternal level (51±4 vs. 161±11 ng/100 ml, mean ±SE). Mean free T3 concentration was also lower in the cord samples (0.15±0.02 vs. 0.31±0.04 ng/100 ml). whereas total and free T4 concentrations were not significantly different. Umbilical vein and artery samples from 11 neonates did not differ significantly in their T3 and T4 concentrations. In seven infants the mean T3 concentration increased from 51±3 ng/100 ml at delivery to 79±13 at 15 min and 191±16 at 90 min. In four other infants the mean T3 concentration at 24 and 48 h was not significantly different from the 90 min value of the previous group. Less pronounced changes were observed for T4 which increased from 12.3±2.0 μg/100 ml (mean ±SE) at delivery to 14.1±1.9 at 90 min and appeared to have reached a plateau at approximately twice the cord value by 24-48 h after delivery.
Curriculum Changes: Pass or Fail for Town and Gown
Authors: LOCKHART B. MCGUIRE
Journal: Annals of Internal Medicine (1968)

Increased activity of medical schools in the direct provision of medical services is being advocated, both for the purpose of better distribution of expert medical care and for more balanced medical education. Such a trend could either intensify or ameliorate existing differences between academic and non-academic physicians. Characteristics of the educational setting that may complicate medical care include the varied levels of personnel involved, an emphasis on general scientific insights as well as providing of individual patient care, and often relatively aggressive diagnostic and therapeutic attitudes. Characteristics of practicing physicians include a relative emphasis on the emotional and material satisfactions of medical practice, sometimes at the expense of scientific competence and intellectual stimulation, and defensiveness about previous modes of organizing and financing medical care. Each group should review its strengths and liabilities in search of rapport. Medical education is undergoing a major reassessment of its purposes and methods. After the Flexner report both educators and the practicing profession chose to maintain high standards of both basic scientific education and clinical training. The need for students at all levels to experience both the practice of medicine in the community as well as in the academic center and to move freely from one to the other is now coming into focus. Both the requirements of medical education and the hope of improved distribution of medical care to the public indicate a need for more active, continuing collaboration between "gown" and "town" than has recently prevailed.
Cyclic AMP Response Element-Binding Protein in the Vessel Wall
Authors: Jane E.B. Reusch, Dwight J. Klemm
Journal: Circulation (2003)

therosclerosis and postangioplasty restenosis are leading causes of death in the Western world.Recent advances in our understanding of vascular biology would suggest that targeting specific signals in the post-balloon injury vessel or in persons prone to development of atherosclerosis could decrease lesion formation and in the long term decrease cardiovascular events.In light of this, numerous laboratories around the world are investigating the functional activities of the various cellular components of the atherosclerotic plaque, including vascular smooth muscle cells (SMCs), endothelial cells (ECs), and monocyte/macrophages.
Endostatin may stop the progression of atherosclerosis
Authors: S. Gottlieb
Journal: BMJ (1999)

The experimental drug endostatin, which is being developed for its ability to shrink cancerous tumours by inhibiting the development of new blood vessels, is also showing promise in stopping atherosclerosis.

Researchers have found that endostatin significantly reduced atherosclerosis in genetically susceptible mice. In the 16 week experiment …
Impact of Microvascular Obstruction on the Assessment of Coronary Flow Reserve, Index of Microcirculatory Resistance, and Fractional Flow Reserve After ST-Segment Elevation Myocardial Infarction
Authors: Florim Cuculi, Giovanni Luigi De Maria, Pascal Meier, Erica Dall'Armellina, Alberto R. de Caterina, Keith M. Channon, Bernard D. Prendergast, Robin C. Choudhury, John C. Forfar, Rajesh K. Kharbanda, Adrian P. Banning
Journal: Journal of the American College of Cardiology (2014)
COL7A1 mutational analysis in Korean patients with dystrophic epidermolysis bullosa
Authors: S-W. Oh, J.S. Lee, M.Y. Kim, S-C. Kim
Journal: British Journal of Dermatology (2007)

Conflicts of interest: none declared. Dystrophic epidermolysis bullosa (DEB) is an inherited blistering skin disorder, characterized by mucocutaneous blistering, scarring and nail dystrophy following minor trauma. DEB is caused by mutations in the COL7A1 gene and occurs either as an autosomal dominant (DDEB, MIM 131750) or as a recessive (RDEB, MIM 226600) trait. The phenotypic variability results from the different types of mutations in COL7A1 and their positions within the gene. In most cases, RDEB has a more severe clinical presentation.1 The most severe type of DEB, the recessive Hallopeau–Siemens variant (HS‐RDEB), is caused by the presence of mutations that lead to premature termination codons (PTCs) in both alleles, whereas the autosomal dominant cases are frequently caused by heterozygous glycine substitutions (GSs) within the collagenous triple helix. To date, more than 500 different mutations of COL7A1 have been reported.2 In this study, mutational analysis was performed in 18 distinct Korean families with DEB, and a computational study of each mutation was carried out.
Molecular analysis of β‐thalassemia in South Vietnam
Authors: M.L. Saovaros Svasti, Tran Minh Hieu, Thongperm Munkongdee, Pranee Winichagoon, Tran Van Be, Tran Van Binh, Suthat Fucharoen
Journal: American Journal of Hematology (2002)

Abstract In Vietnam, the carrier rate for β‐thalassemia varies from 1.5% to 25% depending on the ethnic groups of the population. The molecular basis of β‐thalassemia in South Vietnam was studied in 50 unrelated β‐thalassemia patients. Of these, 31 had β‐thalassemia/Hb E, 18 were homozygous for β‐thalassemia, and 1 carried the β‐thalassemia trait. The majority of the patients were Kinh, four were Chinese, and two were Kinh–Chinese. All had severe anemia and received blood transfusions regularly, every 1–3 months. Hepatosplenomegaly was found in all patients, and splenectomy had been done in six patients. Normal α‐globin genotype (αα/αα) was found in all subjects. Reverse dot‐blot hybridization using oligonucleotide probes specific for Southeast Asian mutations can detect β‐thalassemia in 60 chromosomes in addition to 31 chromosomes with β E mutation. Excluding the β E gene, six previously reported Thai and Chinese β‐thalassemia mutations were found, including codons 41/42 (−TCTT) 35.3%, codon 17 (A→T) 25.0%, −28 (A→G) 7.3%, codons 71/72 (+A) 7.3%, IVS‐II nt 654 (C→T) 7.3%, and IVS‐I nt 1 (G→T) 6.0%. The Vietnamese frameshift mutation at codon 95 (+A) was detected by ARMS in seven chromosomes (10.3%). DNA polymorphism of the β‐globin gene cluster carrying the codon 95 mutation was − + − − − − − + for G γ/ Xmn I, ϵ/ Hin cII, G γ/ Hin dIII, A γ/ Hin dIII, ψβ/ Hin cII, 3′ ψβ/ Hin cII, β/ Ava II, and 3′β/ Bam HI, respectively. The remaining mutation detected by the gap PCR was a large deletion known as the Chinese G γ( A γδβ) 0 ‐thalassemia. The two most common mutations were the frameshift at codons 41/42 (−TCTT) and the nonsense mutation in codon 17 (A→T). Thus β‐thalassemia mutations in South Vietnam is similar to the previous report from the North, although at different frequencies. This result will help to establish a center for prenatal diagnosis and for prevention and control of thalassemia in Vietnam. Am. J. Hematol. 71:85–88, 2002. © 2002 Wiley‐Liss, Inc.
Mimicry between neurokinin-1 and fibronectin may explain the transport and stability of increased substance P immunoreactivity in patients with bone marrow fibrosis
Authors: Pranela Rameshwar, Deval D. Joshi, Prem Yadav, Jing Qian, Pedro Gascon, Victor T. Chang, Devashish Anjaria, Jonathan S. Harrison, Xiaosong Song
Journal: Blood (2001)
Prolonged action potentials in HCM-derived iPSC - biology or artefact?
Authors: T. Christ, J. T. Koivumaki, T. Eschenhagen
Journal: Cardiovascular Research (2015)

With great interest we read the article by Han et al. ‘Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells’ recently published in ‘Cardiovascular Research’.1 Life-threatening ventricular arrhythmias in hypertrophic cardiomyopathy (HCM) remain a challenge not only for clinical management of individual patients, but also from the viewpoint of cellular cardiac electrophysiology. It remains an enigma how mutations of sarcomeric proteins can increase the propensity for arrhythmias. A recent concept suggests that the often increased Ca2+-binding affinity of mutated sarcomeres in HCM increases Ca2+ buffering and, by diastolic release of Ca2+, the propensity for arrhythmias.2 The advantage of patient-specific induced pluripotent stem cells (iPSC) should be that effects of patient-relevant mutations can be studied in the correct genetic …
A natural killer cell receptor specific for a major histocompatibility complex class I molecule.
Authors: B F Daniels, F M Karlhofer, W E Seaman, W M Yokoyama
Journal: The Journal of Experimental Medicine (1994)

Target cell expression of major histocompatibility complex (MHC) class I molecules correlates with resistance to lysis by natural killer (NK) cells. Prior functional studies of the murine NK cell surface molecule, Ly-49, suggested its role in downregulating NK cell cytotoxicity by specifically interacting with target cell H-2Dd molecules. In support of this hypothesis, we now demonstrate a physical interaction between H-2Dd and Ly-49 in both qualitative and quantitative cell-cell binding assays employing a stable transfected Chinese hamster ovary (CHO) cell line expressing Ly-49 and MHC class I transfected target cells. Binding occurred only when CHO cells expressed Ly-49 at high levels and targets expressed H-2Dd by transfection. Monoclonal antibody blocking experiments confirmed this interaction. These studies indicate that the specificity of natural killing is influenced by NK cell receptors that engage target cell MHC class I molecules.
The Consequences of Feminization in Breeding Groups of Wild Fish
Authors: Catherine A. Harris, Patrick B. Hamilton, Tamsin J. Runnalls, Veronica Vinciotti, Alan Henshaw, Dave Hodgson, Tobias S. Coe, Susan Jobling, Charles R. Tyler, John P. Sumpter
Journal: Environmental Health Perspectives (2010)

BackgroundThe feminization of nature by endocrine-disrupting chemicals (EDCs) is a key environmental issue affecting both terrestrial and aquatic wildlife. A crucial and as yet unanswered question is whether EDCs have adverse impacts on the sustainability of wildlife populations. There is widespread concern that intersex fish are reproductively compromised, with potential population-level consequences. However, to date, only in vitro sperm quality data are available in support of this hypothesis.ObjectiveThe aim of this study was to examine whether wild endocrine-disrupted fish can compete successfully in a realistic breeding scenario.MethodsIn two competitive breeding experiments using wild roach (Rutilus rutilus), we used DNA microsatellites to assign parentage and thus determine reproductive success of the adults.ResultsIn both studies, the majority of intersex fish were able to breed, albeit with varying degrees of success. In the first study, where most intersex fish were only mildly feminized, body length was the only factor correlated with reproductive success. In the second study, which included a higher number of more severely intersex fish, reproductive performance was negatively correlated with severity of intersex. The intersex condition reduced reproductive performance by up to 76% for the most feminized individuals in this study, demonstrating a significant adverse effect of intersex on reproductive performance.ConclusionFeminization of male fish is likely to be an important determinant of reproductive performance in rivers where there is a high prevalence of moderately to severely feminized males.
Nonremoval of Dentures During Anesthesia
Authors: Charles F. Pearson
Journal: JAMA (1974)

<h3>To the Editor.—</h3> For the past ten years, the eight-member Department of Anesthesia at this hospital has been encouraging patients to retain their full dentures in the operating room. We prefer that partial dentures be left at the patient's bedside. The full dentures are usually left in place during general anesthesia with a mask, but are removed before endotracheal intubation. In almost all instances, the dentures are replaced in the patient before he leaves the recovery room. The personnel are fully cognizant of the care of and the return to the patient of the dentures. As a result, our experience has been damage to only one denture and the loss of none in several thousand cases. The major problem has been persuading new nursing personnel on the wards to follow the policy of sending patients to surgery with dentures in place. The preoperative anesthesia questionnaire, given to all surgical patients,
Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.
Authors: N Enomoto, I Sakuma, Y Asahina, M Kurosaki, T Murakami, C Yamamoto, N Izumi, F Marumo, C Sato
Journal: Journal of Clinical Investigation (1995)

We have previously demonstrated that sensitivity to interferon is different among hepatitis C virus (HCV) quasispecies simultaneously detected in same individuals and that interferon-resistant HCV quasispecies are selected during the treatment. To determine the genetic basis of their resistance to interferon, HCV genotype-1b was obtained from serum of three patients before and during interferon therapy, and their full-length nucleotide and deduced amino acid sequences were determined. Comparison of the pairs of interferon-resistant and interferon-sensitive HCV isolates in respective individuals demonstrated clusters of amino acid differences in the COOH-terminal half of the NS5A region (codon 2154-2383), which contained a common unique amino acid difference at codon 2218. Additional sequence data of the COOH-terminal half of the NS5A region obtained from six interferon-resistant and nine interferon-sensitive HCV confirmed the exclusive existence of missense mutations in a 40 amino acid stretch of the NS5A region around codon 2218 (from codon 2209 to 2248) in interferon-sensitive HCV. On the other hand, this region of interferon-resistant HCV was identical to that of prototype HCV genotype-1b (HCV-J, HCV-JTa, or HC-J4). We designated this region as the interferon sensitivity determining region. Thus, HCV genotype-1b with the prototype interferon sensitivity determining region appears to be interferon-resistant strains. The specific nature of these mutations might make it possible to predict prognostic effects of interferon treatment.
Boehringer Ingelheim increases access to clinical trial data
Authors: Z. Kmietowicz
Journal: BMJ (2014)

Boehringer Ingelheim has become the latest drug company to commit to releasing full data it holds on the clinical trials it has conducted on its products once they are approved or after their development has been abandoned.

In an announcement on 12 May the German company said that researchers will be able to request clinical study reports and other clinical documents, including de-identified patient level study data, through its website (trials.boehringer-ingelheim.com/trial_results.html).

The requests will have to be approved by an independent external review panel, and researchers will have to sign a data sharing agreement in which they promise to use the data only for the purpose of …
Determination of stroke volume and cardiac output during exercise: comparison of two-dimensional and Doppler echocardiography, Fick oximetry, and thermodilution.
Authors: J Christie, L M Sheldahl, F E Tristani, K B Sagar, M J Ptacin, S Wann
Journal: Circulation (1987)

Simultaneous estimates of cardiac output were made during graded upright maximal exercise in 10 male subjects by means of Doppler velocity spectrum of ascending aortic flow, apical two-dimensional echocardiograms, thermodilution, and Fick oximetry. In 15 subjects, aortic annular and root diameters were measured during similar exercise from parasternal two-dimensional echocardiograms. The linear correlation between Doppler, two-dimensional echocardiography, and the invasive estimates ranged from r = .78 to r = .92. Both echocardiographic techniques were able to predict changes in invasive flow estimates with reasonable accuracy. Two-dimensional echocardiographic flow estimates underestimated invasive values by about 60%. The accuracy of Doppler flow estimates varied with the method of estimating aortic cross-sectional area. Greatest accuracy was obtained with areas calculated from diameters measured at the aortic value anulus with the leading edge-to-leading edge method of measurement. Correlation coefficients comparing Doppler and thermodilution flow estimates were generally higher (r = .75 to .96, mean .86) for individuals than for the group, but accuracy of the Doppler estimates in single subjects was quite variable. Aortic diameters did not increase from rest to moderate levels of upright exercise. A 3% to 5% increase in resting aortic diameter was noted in the upright posture as compared with the supine. Doppler flow estimates were obtained in all subjects to maximal exertion but in only a minority of subjects with two-dimensional echocardiography or thermodilution. Thus two-dimensional and Doppler echocardiography offer a noninvasive means of estimating cardiac output during vigorous exercise. The Doppler technique is technically more suitable to the study of exercise than two-dimensional echocardiography.(ABSTRACT TRUNCATED AT 250 WORDS)
The Pathogenesis of Acute Tropical Sprue.
Authors: William O'Brien
Journal: Annals of Internal Medicine (1968)

s1 May 1968The Pathogenesis of Acute Tropical Sprue.William O'Brien, F.R.C.P.William O'Brien, F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1149_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe prevalence of tropical sprue among British servicemen and their adult dependents in Southeast Asia presented an opportunity to study the pathogenesis of this syndrome in a young population unaffected by malnutrition, pregnancy, and other extraneous factors. Fifty consecutive patients with uncomplicated sprue were investigated by conventional methods and divided into groups according to the duration of their symptoms. Malabsorption of fat, xylose, and vitamin B12was found in every patient, including 14 who had been ill for less than 3 months. In this group jejunal biopsies showed a leaf pattern, and histological villous measurements were within normal limits in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: William O'Brien, F.R.C.P.Affiliations: Millbank, London PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1149-1149KeywordsBiopsyFatsMalnutritionPathogenesisPregnancyXyloseYoung adults ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
How to implement monitoring tools for sedation, pain and delirium in the intensive care unit: an experimental cohort study
Authors: Finn M. Radtke, Anja Heymann, Martin Franck, Friederike Maechler, Tanja Drews, Alawi Luetz, Irit Nachtigall, Klaus-Dieter Wernecke, Claudia D. Spies
Journal: Intensive Care Medicine (2012)
Lugol chromoendoscopy: might it be useful to improve detection of early dysplastic or neoplastic lesions of the anal canal in high-risk patients?
Authors: M. Antonietti, S. Lecleire, E. Ben Soussan, B. Paillot, F. Di Fiore, E. Lerebours, P. Ducrotté
Journal: Endoscopy (2008)

Lugol is a vital dye that reacts with the glycogen of malpighian nonkeratinized epithelia. Normal mucosa is stained brown by Lugol, whereas pathologic mucosa remains unstained [1]. In smokers and those with alcohol addiction, Lugol increases the sensitivity of the endoscopic detection of dysplasia and squamous cell carcinoma of the esophagus [2]. We wondered whether Lugol might also improve detection of such lesions in the anal canal of high-risk patients. Indeed, most of the anal canal is covered with malpighian nonkeratinized epithelium, separated from the glandular rectal mucosa by a transitional cell epithelium.
AN INVESTIGATION INTO THE ETIOLOGY OF PUERPERAL FEVER
Authors: J. W. Bigger, G. Fitzgibbon
Journal: BMJ (1925)

V/ -WHILE certain cases of ptuerperal sepsis are due to staphylococci, B. coli, or other bacteria, the miiajority are attri- butable to streptococei.Of these the.greater number are 'caused.by lhaemolytic streptococci (chiefly Strep.pIyogenes), but the residue of cases, due to non-haemolytic streptococci { riv'iidans type) are sufficiently numerous to deserve 'consideration.Infectioni of the uterus, as of other parts of the body, nay be either exogenous or endogenous.There can be no 'doubt that a true exogenous infection does occur, as is sh1own by the recorded instances of doctors and midwives acting as carriers of infection.In many cases, however, the possibility of this mode of infection seems to be slight, andl it was with the object of throwing light on what may,
Head and Neck Pathology: Atlas for Histologic and Cytologic Diagnosis
Authors: David Schembri-Wismayer
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
840 ENDOSCOPIC VARICEAL LIGATION IS HIGHLY EFFECTIVE IN THE PREVENTION OF VARICEAL REBLEEDING IN HEMODYNAMIC NON-RESPONDERS TO PHARMACOLOGICAL THERAPY
Authors: S. Augustin, A. González, L. Muntaner, M. Pérez, M. Abu-Suboh, J. Dot, J. Genescà
Journal: Journal of Hepatology (2010)