tbuckley/cabot-search huggingface dataset:
Abstract P5-14-18: Indication of post-mastectomy radiation associated with risk of local recurrence in breast cancer patients with 1-3 lymph node metastasis
Authors: A Saruwatari, M Ishida, Y Koi, S Akiyoshi, A Igawa, M Oikawa, C Koga, S Nishimura, Y Nakamura, S Ohno
Journal: Cancer Research (2013)

Abstract Objective: Post-mastectomy radiotherapy (PMRT) is strongly recommended for breast cancer patients with 1 to 3 axillary lymph node metastasis (N1-3) in NCCN guidelines Version 3.2013 (category 1), whereas the indication of that treatment should be considered individually according to the risk of local recurrence (St Gallen Consensus Meeting 2013). In order to support decision making of PMRT, we evaluated the risk factors of local recurrence after mastectomy. Patients and methods: We reviewed retrospectively 2422 cases with Stage I – III primary breast cancer receiving surgery at National Kyushu Cancer Center between 2000 and 2009. Seven hundred seventy six of them underwent mastectomy, and 547 of them received no PMRT. We analyzed the risk of local recurrence in relation to clinicopathologial factors, the status of hormone receptor and HER2, especially in cases with N1-3. Results: Among 547 cases with no PMRT, there were 364 cases with no LN metastasis (N0), 146 N1-3, and 37 N≥4, and 5-year local disease free survival (DFS) rates were 97.0%, 91.2%, and 73.4%, respectively. In N1-3 (146) cases who underwent no post-operative regional radiotherapies, the 5-year DFS in extent of lymph vessel infiltration (ly) were: ly0 was 97.9% (50) and ly1-3 was 87.9% (92) (ly unknown were 4). In the ly0 cases, the 5-year local DFSs were 100% in grade 2 and 85.7% in grade 3; 100% in ER positive and 90.0% in ER negative; 90.9% in HER2 positive and 100% in HER2 negative. Those in the cases of ly1-3 were 94.5% and 73.4%, 88.7% and 76.6%, and 91.0% and 64.3%, respectively. Conclusion: In patients with N1-3 breast cancer, the risk of local recurrence after mastectomy was significantly related to grade, extent of lymph vessel infiltration, ER and HER2. PMRT could be omitted in case with ly0,additionaly with grade 1-2, ER positive and HER2 negative. The remaining cases have the risk of local recurrence over 10%, if they don't receive PMRT, in which the indication of PMRT should be considered. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-14-18.
Effective treatments for mental illness not being used, WHO says
Authors: P. Brown
Journal: BMJ (2001)

<h3>Background and aims</h3> In our NICU nurses assess the neonates’ pain with the validated COMFORTneo scale three times per day and additionally if they suspect pain. We treat more and more extremely premature neonates from 24 weeks gestation. In this study we explore if the COMFORTneo scale is valid for these extreme premature neonates. <h3>Methods</h3> COMFORTneo scores and Numeric Rating Scale (NRS) scores for pain and distress from 2011 were extracted from the patient data management system. We selected scores assigned in the first 28 postnatal days and considered three gestational age groups: extreme prematures: 23.6 to 27.0 wks, prematures: 27.1 to 35.6 weeks and term borns: 36 weeks and older. <h3>Results</h3> We retrieved 9915 scores in 638 newborns. The median number of scores per patient was 41 (IQR 28 to 55) for 76 extreme prematures; 8(IQR 3 to 18) for 329 prematures; and 3 (IQR 1 to 9) for 233 term borns. 10.0% of scores for the extreme prematures; 9.1% of scores for the prematures; and 15.8% of scores for the term borns suggested pain or distress (COMFORTneo score ≥ 14). Correlations between the COMFORTneo scale and the NRS pain ranged from 0.42 (extreme prematures) to 0.53 (prematures); those between the COMFORTneo scale and the NRS-distress 0.76 (extreme prematures) to 0.85 (term borns). Internal consistencies varied from Cronbach’s alpha 0.73 (in extreme prematures) to 0.85 (in term borns). <h3>Conclusions</h3> The COMFORTneo scale has acceptable psychometric properties for extreme prematures but we should continue to study other assessment strategies.
Lytic Lesion in the Distal Femur
Authors: William J. Otto
Journal: JAMA (1965)

<h3>Dr. Bruce J. Haskin:</h3> An 8-year-old white girl was admitted complaining of pain in her right knee. Three months prior to admission she fell and struck her right knee, producing pain which was increased by walking and caused a slight limp. The pain gradually decreased until about three weeks prior to admission when she again fell, resulting in increased pain in her knee and limitation of motion. She was otherwise well. Physical examination revealed a blood pressure of 110/70 mm Hg respirations, 16; pulse rate 80 beats per minute, and temperature 99 F (37.2 C). The right knee was moderately swollen, warm, and nontender. There was fluid in the joint, but no bony abnormality could be palpated. Full flexion was slightly limited. The white blood cell count was 10,800, with 65% polymorphonuclear cells and 9% band cells. Hematocrit reading was 40%. Sedimentation rate was normal. The roentgenograms (Figure) were interpreted
Antimicrobial Therapy for Otitis Media With Effusion: The Pittsburgh Response
Authors: Richard M. Rosenfeld
Journal: JAMA (1993)

<h3>To the Editor.</h3> —On reading a recent Commentary by Mandel et al,<sup>1</sup>I was struck by the absence of any reference to the only published meta-analysis<sup>2</sup>addressing the efficacy of antimicrobials for otitis media with effusion (OME) in children. In their overview of 1325 children from 10 randomized clinical trials, Rosenfeld and Post<sup>2</sup>found a 22.8% treatment advantage (95% CI, 10.5% to 35.1%) for antimicrobials over placebo or no drug. What effect—if any—does "The Cantekin Affair"<sup>3</sup>have on the interpretation and validity of this finding? The Cantekin affair concerns one of the 10 studies in the meta-analysis, and relates primarily to the choice of OME outcome measure: algorithm vs tympanometry. Mandel et al<sup>4</sup>initially reported a 14.6% treatment advantage for amoxicillin (95% CI, 5.8% to 23.5%;<i>P</i>=.002) based on an otoscopic-tympanometric algorithm; this outcome measure was therefore used in the meta-analysis. A dissenting version
Letter: Survival of infants with unoperated myeloceles.
Authors: D W Hide
Journal: BMJ (1975)

spects.It is not always practicable, and it should be remembered that the physical attributes of a husband and wife are not always passed on to their children.It would seem more appropriate to us to match only the broad outlines of physical appearance in terms of height and stature.All of our donors are screened in terms of a series of medical and laboratory tests and are also paid at the rate of £4 for each sample of semen they provide.Most are university students and are thus assumed to be of reasonable intelligence.The couple requiring insemination are asked to make a contribution of between £5 and £10 into a research fund administered by the local treasurer under our control.This is used to pay the donors.Under normal circumstances the payment covers a woman for up to six consecutive monthly inseminations.It is our impression that the fertility potential of frozen semen is less than that of the fresh.Knowledge of the service has quickly spread and we now have a substantial wait- ing list of nearly 200 couples either under- going investigation, waiting for treatment, or having insemination.We note that various authors have reported variable chances of success.The following facts might prove interesting:Total No of couples referred ... ...
FDG PET Brain Imaging in Neuropsychiatric Systemic Lupus Erythematosis With Choreic Symptoms
Authors: Martin Krakauer, Ian Law
Journal: Clinical Nuclear Medicine (2009)

Chorea is a rare manifestation of neuropsychiatric systemic lupus erythematosus, and is probably caused by immune-mediated hypofunction of the contralateral striatum. Conventional imaging with brain computed tomography or magnetic resonance imaging often fails to show any structural lesions. We report a case of systemic lupus erythematosus-associated chorea in which brain F-18 flourodeoxyglucose positron emission tomography imaging showed disturbances in striatal metabolism in the absence of structural damage on magnetic resonance imaging. A follow-up positron emission tomography scan showed normalization of striatal metabolism, which was correlated with clinical remission.
Abstract 16032: Trends in Smoking among Adults from 1980 to 2009: The Minnesota Heart Survey
Authors: Kristian B Filion, Lyn M Steffen, Sue Duval, David R Jacobs, Henry Blackburn, Russell V Luepker
Journal: Circulation (2010)

Introduction: While the prevalence of smoking has declined, recent smoking trends in the general population are not well studied. We describe these trends in a population-based sample in Minnesota....
Efforts Under Way to Increase Number of Potential Kidney Transplant Donors
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wilson Disease—Penicillamine Therapy and Late Presentation
Authors: Mark B. Skeen
Journal: Annals of Internal Medicine (1992)

Letters1 March 1992Wilson Disease—Penicillamine Therapy and Late PresentationMark B. Skeen, MDMark B. Skeen, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-5-424_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:The review by Stremmel and colleagues (1) is informative and provides a significant analysis of the presentation, evaluation, and long-term course of Wilson disease using current therapies. Their conclusion that the calculated serum free-copper concentration is the most reliable finding for the initial diagnosis and is the best indicator of the effectiveness of copper-reducing therapy is noteworthy. Of specific interest is the significantly reduced incidence of severe side effects of D-penicillamine compared with the incidence reported in previous studies of its use in rheumatoid arthritis, systemic sclerosis, and primary biliary cirrhosis. Current package labeling states "Because of...Reference1. StremmelMeyerroseNiederauHefterKreuzpaintnerStrohmeyer WKCHGG. Wilson disease: clinical presentation, treatment, and survival. Ann Intern Med. 1991;115:720-6. LinkGoogle Scholar1. StremmelMeyerroseNiederauHefterKreuzpaintnerStrohmeyer WKCHGG. Wilson disease: clinical presentation, treatment, and survival. Ann Intern Med. 1991;115:720-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Mark B. Skeen, MDAffiliations: Duke University Medical Center Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnosing Wilson DiseaseJoseph C. Yarze, MD, Santiago J. Munoz, MD, Lawrence S. Friedman, MD 1 March 1992Volume 116, Issue 5Page: 424-425KeywordsAttentionPrimary biliary cirrhosisRheumatoid arthritisScleroderma ePublished: 1 December 2008 Issue Published: 1 March 1992 PDF downloadLoading ...
1183 THE “INTERFERON PARADOX” AS A PREDICTOR OF NON-RESPONSE TO ANTI-VIRAL THERAPY: NOVEL ASSOCIATION WITH APOLIPOPROTEIN E AND HEPATITIS C VIRUS (HCV) LIPOVIRAL PARTICLES (LVP)
Authors: P. Sheridan, S. Bridge, D. Felmlee, S. Taylor Robinson, H. Thomas, G. Toms, D. Neely, M. Bassendine
Journal: Journal of Hepatology (2011)
Is C-Reactive Protein Specific for Vascular Disease in Women?
Authors: Nader Rifai, Julie E. Buring, I-Min Lee, JoAnn E. Manson, Paul M Ridker
Journal: Annals of Internal Medicine (2002)

Background: C-reactive protein (CRP) predicts risk for future cardiovascular events in asymptomatic individuals. However, because CRP also predicts total mortality, its specificity for vascular disease is uncertain. Objective: To compare the predictive value of CRP for cancer and cardiovascular disease, the major determinants of mortality. Design: Prospective, nested case–control study. Setting: The Women's Health Study, an ongoing prospective cohort study involving 28 345 U.S. women 45 years of age and older who were healthy at the time of enrollment. Participants: 643 women who subsequently developed cancer or had cardiovascular events; 643 age- and smoking-matched women who remained free of either disease during 58-month follow-up. Measurements: Baseline CRP levels. Results: Little evidence showed that increasing quartiles of baseline CRP predicted incident cancer (adjusted relative risks, 1.0, 1.2, 1.1, and 1.3; P for trend > 0.2). In contrast, increasing quartiles of baseline CRP were a strong marker of risk for future cardiovascular disease (adjusted relative risks, 1.0, 2.9, 3.4, and 5.6; P for trend < 0.001). Conclusion: C-reactive protein appears to independently predict cardiovascular events but not cancer.
Trust may not discipline psychiatrist who gave leave to schizophrenic patient, court says
Authors: C. Dyer
Journal: BMJ (2010)

A consultant forensic psychiatrist has scored a decisive victory in a long running attempt by her employers to discipline her over an incident in which a paranoid schizophrenic absconded and killed a banker.

Three appeal court judges have upheld a High Court injunction granted last year restraining South West London and St George’s Mental Health Trust from disciplining Gillian Mezey.

John Hendy QC, who represented Dr Mezey, said the appeal court judgment, which analyses the triggers for Department of Health disciplinary procedures, was an important one for NHS hospital doctors.

Lord Justice Ward said the backdrop to the appeal was “a terrible tragedy” in 2004, when John Barrett, a voluntary patient on a secure ward at Springfield Hospital, absconded from …
Association of 1,5-Anhydroglucitol and 2-h Postprandial Blood Glucose in Type 2 Diabetic Patients: Response to Schindhelm et al.
Authors: Christoph Stettler, Matthias Stahl, Sabin Allemann, Peter Diem, Kurt Schmidlin, Marcel Zwahlen, Walter Riesen, Ulrich Keller, Emanuel Christ
Journal: Diabetes Care (2008)

We thank Schindhelm et al. (1) for their highly valuable and important comment referring to our study assessing the association of 1,5-anhydroglucitol (1,5-AG) with 2-h postprandial blood glucose (2). We fully agree with these authors on the importance of impaired renal function as a potential factor modifying the association of 1,5-AG and glucose values (1,3). While patients with frank renal failure were excluded from our study, the impact of …
Are base rates a natural category of information?
Authors: Terry Connolly
Journal: Behavioral and Brain Sciences (1996)

Abstract The base rate fallacy is directly dependent on a particular judgment paradigm in which information may be unambiguously designated as either “base rate” or “individuating,” and in which subjects make two-stage sequential judgments. The paradigm may be a poor match for real world settings, and the fallacy may thus be undefined for natural ecologies of judgment.
Abstract 5262: Disruption of alternative and classical NF-kappaB signaling patterns: Connections to branching morphogenesis and mammary tumorigenesis
Authors: Halina Onishko, Whitney Barham, Lianyi Chen, Dongsheng Cheng, Oleg Tikhomirov, Linda Connelly, Timothy Blackwell, Fiona E. Yull
Journal: Cancer Research (2012)

Abstract NF-kappaB transcription factors including p65 (RelA), RelB, p105/p50, and p100/p52 play roles in mammary development and tumorigenesis. While most studies have focused on classical NF-kappaB signaling (p65/p50), alternative NF-kappaB signaling is elevated in human primary breast tumors and in human breast cancer cell lines. In addition, we have reported that overexpression of p100 within the mouse mammary epithelium during pregnancy and lactation led to ductal thickening and hyperplastic foci. To determine the contribution of alternative NF-kappaB signaling to mammary development and tumorigenesis, we have developed murine transgenic models that enable us to inducibly express activators or inhibitors of classical or alternative NF-kappaB signaling in the mammary epithelium by adding doxycycline to the drinking water of mice. Modulation of both the classical and alternative pathways will enable us to determine the roles that each arm plays independently or synergistically. Using immunoflourescent staining we have identified distinct patterns of expression of the alternative and classical pathways in mammary epithelium, a previously undescribed phenomenon. Classical p65 signaling was found within the luminal cell population and p100/p52 signaling was observed almost exclusively within the basal cell layer. Upon induction of constitutively activated IKK2 or a dominant negative IKBalpha, two regulators of the classical NF-κB pathway, alterations in branching morphogenesis were observed within the developing virgin gland. These branching phenotypes were associated with a break down in the previously observed classical/alternative signaling pattern, as luminal cells were now expressing low levels of p100/p52. Furthermore, this patterning is disrupted during the development of polyoma middle T oncogene induced tumors in which we also observe alternative signaling no longer confined to the basal layer. Ongoing experiments with our newest transgenic model are designed to determine the effects of inducing alternative signaling, through overexpression of p52, within the mammary epithelium. Our models may reveal novel roles for the alternative NF-kappaB pathway in maintaining the basal/luminal structure of mammary epithelial ducts and connect aberrant p100/p52 signaling to tumor progression, potentially identifying a novel therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5262. doi:1538-7445.AM2012-5262
Tumor derived stress triggers C/EBPβ homologous protein (Chop) expression in myeloid derived suppressor cells (MDSC) and mediates immunosuppressive activity
Authors: Paul Thevenot, Rosa Sierra, Patrick Raber, Paulo Rodriguez
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Suppression of anti-tumor T cell responses by MDSC remains a significant barrier in cancer immunotherapy. Although several pathways have been characterized as critical for MDSC-induced suppression, there are currently no therapies to globally and specifically inhibit MDSC function
Psychiatry in a Troubled World: Yesterday's War and Today's Challenge.
Authors: William Claire Menninger
Journal: Annals of Internal Medicine (1948)

The author of this book is the president of the American Psychiatric Association, the American Psychoanalytic Association and the Central Neuropsychiatric Association, in addition to his duties as chairman of the Group for the Advancement of Psychiatry and general secretary of the Menninger Foundation. He has accepted these honors modestly but not lightly. He is conscientious and fearless in his administrative duties as well as in his attitudes and beliefs. The author's background of training and experience, particularly as Chief Consultant in Neuropsychiatry to the Surgeon General of the U. S. Army, has fitted him for the presentation of this comprehensive book. The reader is given a first hand picture of the actual situation and condition of psychiatry in this country at the beginning of World War II, and the obstacles that were necessary to overcome to reach a maximum of efficiency with inadequate personnel and inadequate organization. The author
Negative Signaling Pathways of the Killer Cell Inhibitory Receptor and FcγRIIb1 Require Distinct Phosphatases
Authors: Neetu Gupta, Andrew M. Scharenberg, Deborah N. Burshtyn, Nicolai Wagtmann, Mario N. Lioubin, Larry R. Rohrschneider, Jean-Pierre Kinet, Eric O. Long
Journal: The Journal of Experimental Medicine (1997)

Inhibition of natural killer (NK) cells by the killer cell inhibitory receptor (KIR) involves recruitment of the tyrosine phosphatase SHP-1 by KIR and is prevented by expression of a dominant negative SHP-1 mutant. Another inhibitory receptor, the low affinity Fc receptor for immunoglobulin G (IgG) (Fc gamma RIIb1), has been shown to bind SHP-1 when cocross-linked with the antigen receptor on B cells (BCR). However, coligation of Fc gamma RIIb1 with BCR and with Fc epsilon RI on mast cells leads to recruitment of the inositol 5' phosphatase SHIP and to inhibition of mast cells from SHP-1-deficient mice. In this study, we evaluated the ability of these two inhibitory receptors to block target cell lysis by NK cells, and the contribution of SHP-1 and SHIP to inhibition. Recombinant vaccinia viruses encoding chimeric receptors and dominant negative mutants of SHP-1 and SHIP were used for expression in mouse and human NK cells. When the KIR cytoplasmic tail was replaced by that of Fc gamma RIIb1, recognition of HLA class I on target cells by the extracellular domain resulted in inhibition. A dominant negative mutant of SHP-1 reverted the inhibition mediated by the KIR cytoplasmic tail but not that mediated by Fc gamma RIIb1. In contrast, a dominant negative mutant of SHIP reverted only the inhibition mediated by the Fc gamma RIIb1 tail, providing functional evidence that SHIP plays a role in the Fc gamma RIIb1-mediated negative signal. These data demonstrate that inhibition of NK cells by KIR involves primarily the tyrosine phosphatase SHP-1, whereas inhibition mediated by Fc gamma RIIb1 requires the inositol phosphatase SHIP.