Peptic Ulcer Heterogeneity and Clinical Implications
Authors: DENIS M. MCCARTHY
Journal: Annals of Internal Medicine (1981)

Editorials1 October 1981Peptic Ulcer Heterogeneity and Clinical ImplicationsDENIS M. MCCARTHY, M.D., M.SC.DENIS M. MCCARTHY, M.D., M.SC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-4-507 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe article by Taylor and colleagues in this issue (1) provides additional evidence that peptic ulcer, long regarded as a disease, is in fact a syndrome with many causes (2). In the past, peptic ulcers found in a variety of sites (such as the stomach or duodenum) may have seemed to be part of a continuum of focal histologic damage, the site and severity of the ulcer differing in response to various environmental influences (3). Epidemiologic studies of ulcer disease were pursued largely in the hope of identifying and controlling environmental risk factors thought to apply to a population with...References1. TAYLOR I, CALAM J, and ROTTER J. Family studies of hypergastrinemic, hyperpepsinogenemic I duodenal ulcer. Ann Intern Med. 1981;95:421-5. LinkGoogle Scholar2. ROTTER J. Gastric and duodenal ulcer are each many diseases. Dig Dis Sci. 1981;26:154-9. CrossrefMedlineGoogle Scholar3. KIRK R. Are gastric and duodenal ulcers separate diseases or do they form a continuum? Dig Dis Sci. 1981;26:149-54. CrossrefMedlineGoogle Scholar4. ROTTER J, SAMLOFF I, and RIMOIN D. Genetics and Heterogeneity of Common Gastrointestinal Disorders. New York: Academic Press; 1980:19-127. Google Scholar5. ROTTER J and GROSSMAN M. Genetic aspects of ulcer disease. In: HOLTERMULLER K-H, MALEGALADA J-R, eds. Advances in Ulcer Disease. Amsterdam, The Netherlands: Experta Medica; 1980: 7-26. Google Scholar6. SUSSER M. Causes of peptic ulcer: a selective epidemiologic review. J Chronic Dis. 1967;20:435-56. CrossrefMedlineGoogle Scholar7. ELASHOFF J and GROSSMAN M. Trends in hospital admissions and death rates for peptic ulcer in the United States from 1970 to 1978. Gastroenterology. 1980;78:280-5. CrossrefMedlineGoogle Scholar8. MENDELOFF A. What has been happening to duodenal ulcer? Gastroenterology. 1974;67:1020-2. CrossrefMedlineGoogle Scholar9. TOVEY F. Progress report—peptic ulcer in India and Bangladesh. Gut. 1979;20:329-47. CrossrefMedlineGoogle Scholar10. TOVEY F and TUNSTALL M. Progress report—duodenal ulcer in black populations in Africa south of the Sahara. Gut. 1975;16:564-76. CrossrefMedlineGoogle Scholar11. PAFFENBARGER R, WING A, and HYDE R. Chronic diseases in former college students. Early precursors of peptic ulcer. Am J Epidemiol. 1974;100:307-15. CrossrefMedlineGoogle Scholar12. COOK A. Environmental aspects of ulcer disease. In: HOLTERMULLER K-H, MALEGALADO J-R. Advances in Ulcer Disease. Amsterdam, The Netherlands: Exerpta Medica; 1980: 27-36. Google Scholar13. GRAYSON R. Air controllers syndrome: peptic ulcer in air-traffic controllers. Illinois Med J. 1972;2:111-5. Google Scholar14. MIRSKY I. Physiologic, psychologic, and social determinants in the etiology of duodenal ulcer. Am J Dig Dis. 1958;3:285-314. CrossrefMedlineGoogle Scholar15. MENDELOFF A and DUNN J. Vital and health statistics monographs. In: AMERICAN PUBLIC HEALTH ASSOCIATION, ed. Digestive Diseases. Cambridge Massachusetts: Harvard University Press; 1971. Google Scholar16. BERNARD C. An Introduction to the Study of Experimental Medicine. New York: Macmillan and Co., 1927: 216. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DENIS M. MCCARTHY, M.D., M.SC.Affiliations: University of New Mexico Veterans Administration Medical Center Albuquerque, New Mexico PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTemporal Aspects of the Pathophysiology of Human Ulcer Disease 1 October 1981Volume 95, Issue 4Page: 507-508KeywordsDuodenumGastric ulcersMedical risk factorsPeptic ulcersStomachUlcers ePublished: 1 December 2008 Issue Published: 1 October 1981 PDF downloadLoading ...