The Relationship of the Juxtaglomerular Apparatus to Sodium Retention in Experimental Nephrosis
Authors: LOUIS TOBIAN
Journal: Annals of Internal Medicine (1962)

Article1 September 1962The Relationship of the Juxtaglomerular Apparatus to Sodium Retention in Experimental NephrosisLOUIS TOBIAN, M.D., SANDRA PERRY, B.S., JOHN MORK, B.A.LOUIS TOBIAN, M.D., SANDRA PERRY, B.S., JOHN MORK, B.A.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-3-382 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhenever rats, dogs, or cats are given a sodium deficient diet for a month or 2, the granules in the cytoplasm of juxtaglomerular cells become much more abundant, and the cells themselves often become hyperplastic (1, 2). The opposite effect is seen in rats when a diet containing 7.4 per cent sodium chloride is used. When rats eat these large quantities of salt, the granularity of the juxtaglomerular cells diminishes (3). The actual sodium concentration in the extracellular fluid is scarcely changed by these variations in sodium intake. Hence, attention is focused on changes in extracellular fluid volume or blood...References1. HARTROFTNEWMARKPITCOCK PMLNJA: Relationship of renal juxtaglomerular cells to sodium intake, adrenal cortex and hypertension, in Hypertension, ed. by Moyer, J. H., W. B. Saunders Company, Philadelphia, 1959, p. 24. Google Scholar2. TOBIANTHOMPSONTWEDTJANECEK LJRJ: The granulation of juxtaglomerular cells in renal hypertension, desoxycorticosterone and post-desoxycorticosterone hypertension, adrenal regeneration hypertension, and adrenal insufficiency. J. Clin. Invest. 37: 660, 1958. CrossrefMedlineGoogle Scholar3. TOBIAN L: Physiology of the juxtaglomerular cells. Ann. Intern. Med. 52: 395, 1960. LinkGoogle Scholar4. FRIEDMANFREED MSC: Microphonic manometer for indirect determination of systolic blood pressure in the rat. Proc. Soc. Exp. Biol. 70: 670, 1949. CrossrefMedlineGoogle Scholar5. HARTROFTHARTROFT PMWS: Studies on renal juxtaglomerular cells. I. 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D. ITSKOVITZ, M.D., E. A. HILDRETH, M.D., F.A.C.P., A. M. SELLERS, M.D., F.A.C.P., W. S. BLAKEMORE, M.D., F.A.C.S.Juxtaglomerular Cells 1 September 1962Volume 57, Issue 3Page: 382-388KeywordsAscitesAttentionCellsDietHeartHospital medicineMedical servicesSaltsSodiumSodium chloride Issue Published: 1 September 1962 PDF DownloadLoading ...