The Treatment of Renal Osteodystrophy
Authors: S. W. STANBURY
Journal: Annals of Internal Medicine (1966)

Editorials1 November 1966The Treatment of Renal OsteodystrophyS. W. STANBURY, M.D., F.R.C.P.S. W. STANBURY, M.D., F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1133 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe pathogenesis of azotemic osteodystrophy is still uncertain. The demonstration of impaired intestinal absorption of calcium (1, 2), the occurrence of rickets and osteomalacia (3, 4), and their cure by large amounts of vitamin D are all compatible with an acquired insensitivity to the biological effects of vitamin D (1-5). Hypocalcemia when present is associated with reduced osseous responsiveness to the calcemic action of exogenous parathyroid hormone (6), a functional abnormality also found in simple vitamin D deficiency (7). A degree of secondary hyperparathyroidism is to be expected with vitamin D deficiency, but the osseous manifestations of parathyroid activity are...References1. DENTHARPERPHILPOT CECMGR: Treatment of renal-glomerular osteodystrophy. Quart. J. Med. 30: 1, 1961. MedlineGoogle Scholar2. STANBURYLUMB SWGA: Metabolic studies of renal osteodystrophy. I. Calcium, phosphorus and nitrogen metabolism in rickets, osteomalacia and hyperparathyroidism complicating chronic uremia and in the osteomalacia of the adult Fanconi syndrome. Medicine (Balt.) 41: 1, 1962. CrossrefMedlineGoogle Scholar3. STANBURY SW: Azotaemic renal osteodystrophy. Brit. Med. Bull. 13: 57, 1957. CrossrefMedlineGoogle Scholar4. STANBURY SW: Bony complications of renal disease, in Renal Disease, edited by BLACK, D. A. K. Blackwell, Oxford, 1962, p. 508. (Also 2nd ed., in press, 1966.) Google Scholar5. FLETCHERJONESMORGAN RFJHDB: Bone disease in chronic renal failure. Quart. J. Med. 32: 321, 1963. MedlineGoogle Scholar6. EVANSON JM: The response to infusion of parathyroid extract in hypocalcaemic states. Clin. Sci. 31: 63, 1966. MedlineGoogle Scholar7. RASMUSSENDELUCAARNAUDHAWKERVON STEDINGK HHCCM: The relationship between vitamin D and parathyroid hormone. J. Clin. Invest. 42: 1940, 1963. CrossrefMedlineGoogle Scholar8. KROOKLOWE LJE: Nutritional secondary hyperparathyroidism in the horse. Path. Vet. (suppl. 1), 1964. Google Scholar9. PRENDRASERICKSON JPRV: Hemodialysis: a successful therapy for chronic uremia. Ann. Intern. Med. 64: 293, 1966. LinkGoogle Scholar10. STANBURYLUMB SWGA: Parathyroid function in chronic renal failure. Quart. J. Med. 35: 1, 1966. MedlineGoogle Scholar11. LUMBSTANBURY GASW: The treatment of azotaemic rickets and osteomalacia; observations on the metabolism and therapeutic hazards of vitamin D. In preparation, 1966. Google Scholar12. ALBRIGHTREIFENSTEIN FEC: The Parathyroid Glands and Metabolic Bone Disease. Bailliere, Tindall and Cox, London, 1948. Google Scholar13. STANBURYLUMBNICHOLSON SWGAWF: Elective sub-total parathyroidectomy for renal hyperparathyroidism. Lancet 1: 793, 1960. CrossrefMedlineGoogle Scholar14. ANDERSONMANNKENYONFARRELLHILLS WWJBNJJAG: Subtotal parathyroidectomy in azotemic renal osteodystrophy. New Eng. J. Med. 268: 575, 1963. CrossrefMedlineGoogle Scholar15. WILSONBERNSTEINMURRAYMOORE REDSJEFD: Effects of parathyroidectomy and kidney transplantation on renal osteodystrophy. Amer. J. Surg. 110: 384, 1965. CrossrefMedlineGoogle Scholar16. FINDLEYMOOREBRACKNEY TJDEL: Subtotal parathyroidectomy for renal hyperparathyroidism (letter to the editor). Lancet 2: 1150, 1961. CrossrefGoogle Scholar17. STANBURY SW: Calcium and phosphorus metabolism in chronic renal failure, in Water and Electrolyte Metabolism (II), edited by DE GRAEFF, J., LEIJNSE, B. Elsevier, Amsterdam, 1964. Google Scholar18. WALSER M: The separate effects of hyperparathyroidism, hypercalcemia of malignancy, renal failure, and acidosis on the state of calcium, phosphate, and other ions in plasma. J. Clin. Invest. 41: 1454, 1962. CrossrefMedlineGoogle Scholar19. DAVIESDENTWILCOX DRCEA: Hyperparathyroidism and steatorrhoea. Brit. Med. J. 2: 1133, 1956. CrossrefMedlineGoogle Scholar20. MCPHAULMCINTOSHHAMMONDPARK JJDAWSOK: Autonomous secondary (renal) parathyroid hyperplasia. New Eng. J. Med. 271: 1342, 1964. CrossrefMedlineGoogle Scholar21. HERDMANMICHAELVERNIERKELLYGOOD RCAFRLWDRA: Renal function and phosphorus excretion after human renal homotransplantation. Lancet 1: 121, 1966. CrossrefMedlineGoogle Scholar22. GOLDENCANARYKERWIN AJJDM: Concurrence of hyperplasia and neoplasia of the parathyroid glands. Amer. J. Med. 38: 562, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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ROBERT ARNSTEIN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD M. FROST, M.D.22. Chirurgie der Epithelkörperchen 1 November 1966Volume 65, Issue 5Page: 1133-1138KeywordsCalciumHyperparathyroidismHypocalcemiaParathyroidParathyroid hormonePathogenesisVitamin DVitamin D deficiency Issue Published: 1 November 1966 PDF DownloadLoading ...