tbuckley/cabot-search huggingface dataset:
Human Cardiosphere-Derived Cells From Advanced Heart Failure Patients Exhibit Augmented Functional Potency in Myocardial Repair
Authors: Ke Cheng, Konstantinos Malliaras, Rachel Ruckdeschel Smith, Deliang Shen, Baiming Sun, Agnieszka Blusztajn, Yucai Xie, Ahmed Ibrahim, Mohammad Amin Aminzadeh, Weixin Liu, Tao-Sheng Li, Michele A. De Robertis, Linda Marbán, Lawrence S.C. Czer, Alfredo Trento, Eduardo Marbán
Journal: JACC Heart Failure (2014)

This study sought to compare the regenerative potency of cells derived from healthy and diseased human hearts. Results from pre-clinical studies and the CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial support the notion that cardiosphere-derived cells (CDCs) from normal and recently infarcted hearts are capable of regenerating healthy heart tissue after myocardial infarction (MI). It is unknown whether CDCs derived from advanced heart failure (HF) patients retain the same regenerative potency. In a mouse model of acute MI, we compared the regenerative potential and functional benefits of CDCs derived from 3 groups: 1) non-failing (NF) donor: healthy donor hearts post-transplantation; 2) MI: patients who had an MI 9 to 35 days before biopsy; and 3) HF: advanced cardiomyopathy tissue explanted at cardiac transplantation. Cell growth and phenotype were identical in all 3 groups. Injection of HF CDCs led to the greatest therapeutic benefit in mice, with the highest left ventricular ejection fraction, thickest infarct wall, most viable tissue, and least scar 3 weeks after treatment. In vitro assays revealed that HF CDCs secreted higher levels of stromal cell-derived factor (SDF)-1, which may contribute to the cells' augmented resistance to oxidative stress, enhanced angiogenesis, and improved myocyte survival. Histological analysis indicated that HF CDCs engrafted better, recruited more endogenous stem cells, and induced greater angiogenesis and cardiomyocyte cell-cycle re-entry. CDC-secreted SDF-1 levels correlated with decreases in scar mass over time in CADUCEUS patients treated with autologous CDCs. CDCs from advanced HF patients exhibit augmented potency in ameliorating ventricular dysfunction post-MI, possibly through SDF-1–mediated mechanisms.
AN UNUSUAL TWIN BIRTH: A CASE IN WHICH THE TWO HEADS WERE BORN AT THE SAME TIME
Authors: A. W. Petit
Journal: JAMA (1923)

Mrs. D. R., aged 27, in her fourth full-term normal pregnancy, had not had difficulties at the previous deliveries, eight, six and three years before. The babies had weighed from 6 to 7 pounds (2.7 to 3.2 kg.) each, and there had been no perineal tear except a slight one, repaired at the first delivery. When I arrived at the bedside, July 7, 1923, the patient had been in labor for two hours, and was having strong pains at three-minute intervals. Vaginal examination showed a left occipito-anterior presentation, with the head on the perineum. After a few pains, the vertex progressed so that it was nearly one-half born, but came no farther. Examination to ascertain the cause of this sudden arrest showed a second head in the pelvis pressing into the neck of the first child. The second head was pushed upward, after which the first head was born. In
Epidemiological study of achalasia in children.
Authors: J F Mayberry, M J Mayell
Journal: Gut (1988)

One hundred and twenty nine children under the age of 15 years were diagnosed as having achalasia in Britain and Ireland between 1976 and 1985 by 175 surgeons with an interest in paediatrics or oesophageal disease. The incidence in Eire was 0.31 cases/10(5) population/year and this was significantly higher than in England and Wales (0.1/10(5)/year), Scotland (0.06/10(5)/year/or Northern Ireland (0.02/10(5)/year). Details of age at diagnosis were only obtained for 36 of the 129 patients. The disease appeared to become commoner with increasing age but there is no evidence of a delay in diagnosis until early adulthood. Such a delay would not account for the apparent regional variations in incidence, as they have also been reported in adults. Southern Irish children are at greater risk of the disease than other children in the British Isles.
1021-59 Influence of Cardiac Pacing Mode on Left Atrial Appendage Function: Implication for the Cause of Systemic Embolism in VVI Pacing
Authors: Hiroyuki Yoshitomi, Kazuaki Tanabe, Yo Murakami, Toshihiko Asanuma, Hiromi Shimizu, Sachiko Yamada, Kazuya Sano, Toshio Shimada, Shigefumi Morioka
Journal: Journal of the American College of Cardiology (1995)
Dementias appear to have individual profiles in single photon emission computed tomography
Authors: T. F. Kirn
Journal: JAMA (1989)

A NUMBER OF researchers are seeking clinical applications for single photon emission computed tomographic (SPECT) images of demented patients. They have found that dementias have somewhat individual SPECT profiles. The challenge now, they say, is to determine if the SPECT information is meaningful to the clinician and to develop more specific radiotracers, such as tracers for individual neuroreceptors. The initial work was done with positron emission tomography (PET), a sometimes more sensitive, but much more expensive technique. Recently, a number of centers began trying to duplicate the PET findings using SPECT. Developing SPECT could actually make dementia scanning fairly available, they say. Radiologists estimate that three fourths of the nation's nuclear medicine departments have SPECT scanning machines—either rotating or multiaperture gamma cameras. <h3>Radioligand Now Available</h3> The trick was to develop a radioligand for imaging blood perfusion that would pass through the blood-brain barrier—a lipophilic molecule—but that would stay in the
T Cell Receptor CDR2β and CDR3β Loops Collaborate Functionally to Shape the iNKT Cell Repertoire
Authors: Thierry Mallevaey, James P. Scott-Browne, Jennifer L. Matsuda, Mary H. Young, Daniel G. Pellicci, Onisha Patel, Meena Thakur, Lars Kjer-Nielsen, Stewart K. Richardson, Vincenzo Cerundolo, Amy R. Howell, James McCluskey, Dale I. Godfrey, Jamie Rossjohn, Philippa Marrack, Laurent Gapin
Journal: Immunity (2009)
Junior doctors warn NHS may lose newly qualified medical staff
Authors: Z. Kmietowicz
Journal: BMJ (2001)

The NHS is in danger of losing hundreds of newly qualified doctors that it can ill afford to lose if it fails to guarantee the jobs of those trained under the flexible training scheme, junior doctors warned at their conference last week.

The flexible training scheme, which was set up five years ago to allow some junior doctors to work 40 hours a week rather than 72 hours, is in crisis, the conference heard. Unless emergency measures are implemented to save the scheme, hundreds of doctors will simply leave the health service and find alternative employment. About …
Variation in the Human Genome
Authors: I. D Young
Journal: BMJ (1996)

Ed Derek Chadwick, Gail Cardew Wiley, £52.50, pp 329 ISBN 0 471 96152 3

It will not come as a surprise to doctors that the human genome has been shown to be a complex and diverse entity. Patients show striking and sometimes idiosyncratic differences in their responses to noxious agents and to treatment. If these differences exist today then plausibly they existed in the past, and perhaps this explains why some of our ancestors were able to survive the horrors of famine and plague while others around them succumbed. The underlying explanations for these events must surely lie in our extraordinarily rich and heterogeneous genetic heritage.

The full …
Diabetes Mellitus as a 'Disease of Civilization'
Authors: Robert L. Martensen
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Talc Induces Apoptosis in Human Malignant Mesothelioma Cells <i>In Vitro</i>
Authors: NAJMUNNISA NASREEN, KAMAL A. MOHAMMED, PATRICK A. DOWLING, MELISSA J. WARD, GABRIELLA GALFFY, VEENA B. ANTONY
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Pleurodesis with talc is an accepted method for the treatment of symptomatic pleural effusions secondary to mesotheliomas. Patients with mesothelioma who have talc-induced pleurodesis have a lower morbidity than do those who do not have pleurodesis. The mechanisms whereby talc mediated these effects were considered to be secondary to a decrease or absence of a pleural effusion. The possibility that talc may directly affect malignant cells was not considered. The present study was designed to evaluate if talc directly effects cell death of malignant mesothelioma cells (MMC) or normal pleural mesothelial cells (PMC). Three confluent MMC and PMC were exposed to talc for 24, 48, and 72 h. In parallel experiments, glass beads similar in size to talc were included as control. Apoptosis was determined by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) and DNA electrophoresis. Our results demonstrated that talc at a therapeutically achievable concentration (6 microg/cm(2)) induces significant apoptosis in MMC. Talc-induced maximum apoptosis in MMC (39.50 +/- 2.55%, 31.87 +/- 4.69%, and 15.10 +/- 3.93% in CRL-2081, CRL-5820, and CRL-5915, respectively) at 48 h, which was significantly (p < 0.05) greater than that in control cells. Electrophoresis of DNA isolated from talc-exposed MMC demonstrated the typical ladder pattern of internucleosomal DNA cleavage. Talc did not induce apoptosis in PMC, and glass beads did not cause significant apoptosis in either MMC or PMC. The present study has demonstrated that talc induces apoptosis in MMC without affecting normal mesothelial cells of the pleura.
Biomarkers for individual susceptibility to carcinogenic agents: excretion and carcinogenic risk of benzo[a]pyrene metabolites.
Authors: A J Likhachev, D Sh Beniashvili, V J Bykov, P P Dikun, M L Tyndyk, I V Savochkina, V B Yermilov, M A Zabezhinski
Journal: Environmental Health Perspectives (1992)

In rats exposed to a single intraperitoneal dose of 200 mg/kg of the environmental carcinogen benzo[a]pyrene (BP) in sunflower oil, significant individual variations in excretion of the BP activation (BP-7,8-diol) and deactivation (3-OH-BP) derivatives were found. Most rats developed peritoneal sarcomas. Only the levels of BP-7,8-diol excreted in the urine correlated directly with the latency of tumor formation. After a similar exposure to a dose of 100 mg/kg BP, Macaca fascicularis monkeys excreted smaller quantities than rats of both metabolites. After rats were given 10 intraperitoneal injections each of 10 mg/kg of BP in a water-lipid emulsion, the excreted levels of both metabolites after the first, fifth, and tenth injection were lower than those of the rats that received 200 mg/kg. BP metabolites were also detected in the urine of lung cancer patients who were heavy smokers. The applicability of monitoring the excretion of the BP metabolites to predicting individual cancer risk is discussed.
The Major Infectious Diseases in the World — To Treat or Not to Treat?
Authors: Paul Farmer
Journal: New England Journal of Medicine (2001)

In this issue of the Journal, Tahaoğlu and coworkers report on their experience in treating a cohort of patients infected with strains of Mycobacterium tuberculosis that are resistant to powerful antituberculosis drugs. Tuberculosis caused by strains that are resistant to at least isoniazid and rifampin is, by convention, termed “multidrug-resistant tuberculosis.”1 The authors of this report work in a referral center in Turkey that has available a full complement of clinical, laboratory, and surgical services, including multidrug treatment regimens given for 18 to 24 months, resources for the management of side effects, adjuvant surgery when necessary, and full financial and . . .
Functional Pain
Authors: Neil L. Schechter
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Cutaneous malignancy in arsenicosis.
Authors: K.C. Saha
Journal: British Journal of Dermatology (2001)

Journal Article Cutaneous malignancy in arsenicosis Get access K.C. Saha K.C. Saha The School of Tropical Medicine, EC‐21, Sector 21, Bidhannagar, Calcutta 700 064, India E‐mail: poddars@cal3.vsnl.net.indebasaha@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 1, 1 July 2001, Page 185, https://doi.org/10.1046/j.1365-2133.2001.04316.x Published: 01 July 2001
Revascularization of Chronic Hibernating Myocardium Stimulates Myocyte Proliferation and Partially Reverses Chronic Adaptations to Ischemia
Authors: Brian J. Page, Michael D. Banas, Gen Suzuki, Brian R. Weil, Rebeccah F. Young, James A. Fallavollita, Beth A. Palka, John M. Canty
Journal: Journal of the American College of Cardiology (2015)
Genome-wide patterns of genetic variation in worldwide Arabidopsis thaliana accessions from the RegMap panel
Authors: Matthew W Horton, Angela M Hancock, Yu S Huang, Christopher Toomajian, Susanna Atwell, Adam Auton, N Wayan Muliyati, Alexander Platt, F Gianluca Sperone, Bjarni J Vilhjálmsson, Magnus Nordborg, Justin O Borevitz, Joy Bergelson
Journal: Nature Genetics (2012)
(11) Does a high sebum excretion rate correlate with poor clinical response in patients treated with antibiotics for acne?
Authors: A.M. Layton, B.R. Hughes, S.MacDonald Hull, E.A. Eady, W.J. Cunliffe
Journal: British Journal of Dermatology (1989)

Journal Article (11) Does a high sebum excretion rate correlate with poor clinical response in patients treated with antibiotics for acne? Get access A.M. Layton, A.M. Layton The Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar B.R. Hughes, B.R. Hughes The Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar S.MacDonald Hull, S.MacDonald Hull The Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar E.A. Eady, E.A. Eady The Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar W.J. Cunliffe W.J. Cunliffe The Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue s34, 1 July 1989, Pages 57–58, https://doi.org/10.1111/j.1365-2133.1989.tb05962.x Published: 01 July 1989
Demonstration of a Liver Abscess by ERC
Authors: A. Weizel, P. Czygan
Journal: Endoscopy (1976)

In a patient with septic fever and elevated alkaline phosphatase an ERC was conducted to explore the biliary system. Contrast media could be demonstrated within the hepatic parenchyma, establishing the diagnosis of a liver abscess in communication with the intrahepatic biliary system.
Treatment of Unexplained Syncope
Authors: Daniel Flammang, Timothy R. Church, Luc De Roy, Jean-Jacques Blanc, Jean Leroy, Georges H. Mairesse, Akli Otmani, Pierre J. Graux, Robert Frank, Philippe Purnode
Journal: Circulation (2011)

The origin of 40% of syncope cases remains unknown even after a complete diagnostic workup. Previous studies have suggested that ATP testing has value in selecting successful therapy. This patient-blinded, multicenter, randomized superiority trial tested whether, in patients with syncope of unknown origin, selecting cardiac pacing in those with a positive ATP test leads to fewer recurrences than those who do not receive pacing.From 2000 to 2005, 80 consenting patients (mean age, 75.9±7.7 years; 81% women; 56% without diagnosed structural heart disease) with syncope of unknown origin and atrioventricular or sinoatrial block lasting >10 seconds (average, 17.9±6.8 seconds) under ATP administration (20-mg IV bolus) were recruited from 10 hospitals, implanted with programmable pacemakers, and randomized to either active pacing (dual-chamber pacing at 70 bpm) or backup pacing (atrial pacing at 30 bpm). Patients were followed up regularly for up to 5 years for any syncope recurrence, the primary outcome. Mean follow-up was 16 months. Syncope recurred in 8 of 39 patients (21%) randomized to active pacing and in 27 of 41 (66%) randomized to backup pacing (control), yielding a hazard ratio of 0.25 (95% confidence interval, 0.12-0.56). After recurrence, the 27 recurrent control patients were reprogrammed to active pacing, and only 1 reported subsequent syncope.This study suggests that, in elderly patients with syncope of unknown origin and positive ATP tests, active dual-chamber pacing reduces syncope recurrence risk by 75% (95% confidence interval, 44-88).URL: http://www.controlled-trials.com/ISRCTN00029383. Unique identifier: ISRCTN00029383.
Trials are needed before new devices are used in routine practice in Europe
Authors: P. Storz-Pfennig, M. Schmedders, M. Dettloff
Journal: BMJ (2013)

As the EU debates new legislation to regulate medical devices, <b>Philipp Storz-Pfennig</b>, <b>Mechtild Schmedders</b>, and <b>Matthias Dettloff</b> provide examples from Germany to show why the current proposals do not go far enough and call for further assessment after market approval
Comparison of nebulised aerosol deposition in the lungs of healthy adults following oral and nasal inhalation.
Authors: M L Everard, J G Hardy, A D Milner
Journal: Thorax (1993)

A standard jet nebuliser was used to generate a radiolabelled aerosol and the pattern of deposition within the airways of eight healthy adults was studied with a gamma camera. Penetration of aerosol to the lung was greatly reduced when breathing through the nose compared with mouth breathing.
Treatment of Severe Reflux Esophagitis
Authors: JOEL E. RICHTER
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 April 1986Treatment of Severe Reflux EsophagitisJOEL E. RICHTER, M.D.JOEL E. RICHTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-4-588_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the January issue, Lieberman and Keeffe (1) presented a well-designed study comparing a regimen of cimetidine alone to one of cimetidine and metoclopramide in the treatment of severe reflux esophagitis. Their study should be of particular interest to the practicing physician, because the patients had severe esophagitis that had not previously responded to treatment with an H2-receptor antagonist. This subset of patients with gastroesophageal reflux is the most difficult to treat, and unfortunately their problem has not been addressed by previous clinical studies. Several comments, however, are pertinent to the article and the accompanying editorial (2)....References1. LIEBERMANKEEFFE DE. Treatment of severe reflux esophagitis with cimetidine and metoclopramide. Ann Intern Med. 1986;104:21-6. LinkGoogle Scholar2. CASTELL D. Medical therapy for reflux esophagitis: 1986 and beyond [Editorial]. Ann Intern Med. 1986;104:112-4. LinkGoogle Scholar3. THANIKCHEYSHAKHAMILTONNADELSON KWADN. Bethanechol or cimetidine in the treatment of symptomatic reflux esophagitis. Arch Intern Med. 1982;142:1479-81. CrossrefMedlineGoogle Scholar4. EVLER A. Use of bethanechol for the treatment of gastroesophageal reflux. J Pediatr. 1980;96:321-4. CrossrefMedlineGoogle Scholar5. GRAHAMPATTERSON DD. Double-blind comparison of liquid antacid and placebo in the treatment of symptomatic reflux esophagitis. Dig Dis Sci. 1983;28:559-66. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOEL E. RICHTER, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical Therapy of Reflux Esophagitis4 The medical therapy of reflux oesophagitisClinical efficacy of sucralfate in reflux esophagitisOnce-Daily Administration of Famotidine for Reflux Esophagitis 1 April 1986Volume 104, Issue 4Page: 588-589KeywordsGastroesophageal reflux disease ePublished: 1 December 2008 Issue Published: 1 April 1986 PDF downloadLoading ...
Effects of estrogens on microtubule polymerization in vitro: correlation with estrogenicity.
Authors: M Metzler, E Pfeiffer
Journal: Environmental Health Perspectives (1995)

Several estrogens of diverse classes, namely stilbene estrogens, steroidal estrogens, phytoestrogens, mycoestrogens, lignans, and bisphenol A, were studied for their ability to interfere with the assembly of microtubules under cell-free conditions. Inhibition of microtubules in intact cells may lead to the induction of micronuclei and aneuploidy and thereby contribute to estrogen-mediated carcinogenesis. Diethylstilbestrol and various other stilbene estrogens, as well as bisphenol A, were good inhibitors of microtubule polymerization whereas the other tested compounds were devoid of this activity. Therefore, the ability of estrogenic substances to interact with microtubules does not correlate with the hormonal activity.
Surgical Treatment of Coarctation of the Aorta in a Ten Week Old Infant: Report of a Case
Authors: JOHN W. KIRKLIN, HOWARD B. BURCHELL, DAVID G. PUGH, EDMUND C. BURKE, STEPHEN D. MILLS
Journal: Circulation (1952)

Although most patients with coarctation of the aorta survive to early adult life, it has been adequately demonstrated that some patients die in infancy and early childhood as a result of their coarctation. In selected cases, then, operation is advisable at a very early age. Cardiac failure in a 10 week old infant necessitated operation at this age in the case reported.