Management of Typhoid Fever and Its Complications
Authors: THEODORE E. WOODWARD
Journal: Annals of Internal Medicine (1964)

Review1 January 1964Management of Typhoid Fever and Its ComplicationsTHEODORE E. WOODWARD, M.D., F.A.C.P., JOSEPH E. SMADEL, M.D.THEODORE E. WOODWARD, M.D., F.A.C.P., JOSEPH E. SMADEL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-1-144 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFifteen years have elapsed since chloramphenicol was first employed for the treatment of typhoid fever. During this period, it has become the accepted drug for the control of the acute typhoidal infection. We thought it worth-while to review the published experience with the use of this antibiotic in this disease and also to review the current concepts regarding the management of complications including the carrier state.TREATMENT OF THE ACUTE DISEASEThe treatment of patients with typhoid fever remained symptomatic and supportive until 1948 when, with our colleagues in Malaya, it was possible to demonstrate that chloramphenicol drastically shortens the...References1. WOODWARDSMADELLEYGREENMANKIKAR TEJEHLRDS: Preliminary report on the beneficial effect of chloromycetin in the treatment of typhoid fever. Ann. Intern. Med. 29: 131, 1948. LinkGoogle Scholar2. SMADELWOODWARDBAILEY JETECA: Relation of relapses in typhoid to duration of chloramphenicol therapy. JAMA. 141: 129, 1949. CrossrefMedlineGoogle Scholar3. WOODWARDSMADELLEY TEJEHL: Chloramphenicol and other antibiotics in the treatment of typhoid fever and typhoid carriers. J. Clin. Invest. 29: 87, 1950. CrossrefMedlineGoogle Scholar4. 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SHOWACREHOPPSDU BUYSMADEL JLHEHGJE: Effect of antibiotics on intracellular Salmonella typhosa. I. Demonstration by phase microscopy of prompt inhibition of intracellular multiplication. J. Immun. 87: 153, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THEODORE E. WOODWARD, M.D., F.A.C.P.; JOSEPH E. SMADEL, M.D.Affiliations: Baltimore, MarylandFrom the Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, and the Division of Biologics Standards, National Institutes of Health, United States Public Health Service, Bethesda, Maryland.This review is a slightly modified form of a report prepared at the request of the State Department for inclusion among the United States' papers provided to the United Nations Conference on the Application of Science and Technology for the Benefit of the Less Developed Areas.Requests for reprints should be addressed to Theodore E. Woodward, M.D., Department of Medicine, University of Maryland School of Medicine, Baltimore 1, Maryland.Dr. Smadel died on July 21, 1963. 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PAUL ROBERTSON, FRANK O. RAASCHGLUCOCORTICOIDS IN INFECTIOUS DISEASESAkut bedrohliche Infektionskrankheiten 1 January 1964Volume 60, Issue 1Page: 144-157KeywordsAntibioticsChloramphenicolHormonesHygieneMedical servicesPatientsPenicillinPrevention, policy, and public healthSalmonellaTyphoid ePublished: 1 December 2008 Issue Published: 1 January 1964 PDF downloadLoading ...