Myoglobinuria and Persistence of Fetal Myoglobin
Authors: Frederick L. Benoit, George B. Theil, Raymond H. Watten
Journal: Annals of Internal Medicine (1964)

Case Studies1 December 1964Myoglobinuria and Persistence of Fetal MyoglobinFREDERICK L. BENOIT, GEORGE B. THEIL, M.D., RAYMOND H. WATTENFREDERICK L. BENOITSearch for more papers by this author, GEORGE B. THEIL, M.D.Search for more papers by this author, RAYMOND H. WATTENSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-6-1133 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe presence of a muscle heme protein distinct from adult myoglobin was first shown in fetal calves' hearts by Jonxis and Wadman (1) in 1952. Subsequently, "fetal" myoglobin was identified in human newborn muscle, and its replacement by adult myoglobin in the first 6 months of life was shown (2). These proteins differ in their electrophoretic mobilities and solubility in ammonium sulfate; fetal myoglobin is less soluble in ammonium sulfate and has a faster rate of migration when subjected to electrophoresis than the adult protein. In addition, dissimilar absorption spectra have been noted between the two proteins (2, 3).The...References1. JONXISWADMAN JHSK: A foetal form of myoglobin. Nature (London) 169: 884, 1952. CrossrefMedlineGoogle Scholar2. SINGERANGELOPOULOSRAMOT KBB: Studies on human myoglobin. II. Fetal myoglobin: its identification and its replacement by adult myoglobin during infancy. Blood 10: 987, 1955. CrossrefMedlineGoogle Scholar3. WHORTONHUDGINSCONNERS CMPCJJ: Abnormal spectrophotometric absorption spectrums of myoglobin in two forms of progressive muscular dystrophy. New Eng. J. Med. 265: 1242, 1961. CrossrefMedlineGoogle Scholar4. PERKOFFBROWNTYLER GTDHFH: Isolation myoglobin in progressive muscular dystrophy. J. Clin. Endocr. 17: 1489, 1957. 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CrossrefMedlineGoogle Scholar18. MOTULSKY AG: Controller genes in synthesis of human hemoglobin. Nature (London) 194: 607, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Clinical Investigation Center, U. S. Naval Hospital, Oakland, Calif.This work was supported in part by contract Nonr-222(51) (MR105 156) between the Office of Naval Research, Department of the Navy and the Department of Medicine, University of California School of Medicine, San Francisco, Calif.Presented in part at the Forty-fifth Annual Session of the American College of Physicians, April 7, 1964, at Atlantic City, N. J.Requests for reprints should be addressed to R. H. Watten, Cdr. MC USN, Director, Clinical Investigation Center, U. S. Naval Hospital, Oakland, Calif. 94627 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe amino acid sequence of human myoglobin and its minor fractionsMyoglobinuriaIdiopathic rhabdomyolysisCharacteristics of Adult and Foetal Myoglobin in the Visible Light SpectrumsRECURRENT RHABDOMYOLYSIS PRECIPITATED BY ALCOHOL: A CASE REPORT WITH PHYSIOLOGICAL AND ELECTRON MICROSCOPIC STUDIES OF SKELETAL MUSCLEMyoglobin 1 December 1964Volume 61, Issue 6Page: 1133-1139KeywordsAttentionExcretionHemeMuscle proteinsMusclesMyocardiumProteinsSulfates Issue Published: 1 December 1964 PDF DownloadLoading ...