tbuckley/cabot-search huggingface dataset:
Steven Tarquin Goulding
Authors: P. Goulding
Journal: BMJ (2002)

Consultant anaesthetist Scunthorpe General Hospital since 1995 (b 1961; q Guy's Medical School 1986; FRCA), was killed in a road traffic incident on 24 January 2002.

Steven had special interests in the treatment of postoperative pain and in children's anaesthetics. He was an able trainer of junior colleagues and active in the management of the anaesthetic department and the hospital as a whole. A devoted family man and a lover of animals and the outdoor life, he was at his happiest working in his smallholding or walking his Newfoundland dogs with his family. He leaves a wife, Vicky; two children; and an unborn child due in March.
Investigation discovers fraud in more than half of first tranche of psychologist's research papers
Authors: T. Sheldon
Journal: BMJ (2012)

The first in a series of academic investigations into the “unprecedented” scientific fraud committed by Dutch former professor of social psychology Diederik Stapel has judged more than half of his publications to be fraudulent.

The investigating committee chaired by emeritus professor in psycho-linguistics Pim Levelt has so far only investigated a small part of his research published while employed by Tilburg University (www.commissielevelt.nl). The information is being published online as soon as the results become available as a service to the scientific community.

Out of 20 publications dating from 2008 to 2011, fraud was determined in 12. …
Lymphocyte sensitivity in cancer.
Authors: D Hughes, D W Paty
Journal: BMJ (1971)

was present but caused her little inconveni- ence.Repeat arteriography showed occlusion of the whole of the popliteal artery with well marked coUaterals.She refused further op- eration in view of the paucity of her symptoms.Occlusion of the artery was due to contact between the intimal surfaces of the vessel without thrombosis.Conservative removal of the gel restored pulsation, and patency of the artery was demonstrated arteriographically following the operation.However, re- occlusion occurred within one year, and this supports the opinion that in cases of complete occlusion arterial resection with auto- genous vein grafting should be performed in preference to simple evacuation of the cyst.-Iam, etc.,
Effects of Bed Bug Saliva on Human Skin
Authors: Jerome Goddard, Kristine T. Edwards
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
What information is available on request from drug advertisers in India?
Authors: R K Dikshit, N Dikshit
Journal: BMJ (1996)

Key messages* Women have been reported to have higher case fatality after admission to hos- pital after myocardial infarction * Data from a community based coronary heart disease register were used to examine sex differences in case fatality before and after admission * Women had a higher case fatality after admission but a lower case fatality before admission * Total case fatality 28 days after an acute cardiac event showed no significant difference between men and women * The higher case fatality after an acute cardiac event in women admitted to hospital is largely explained by confounding sion, little angiographic information was available, and previously postulated theories which associated the extent and severity of infarcts to sex related differences in mortality were not assessed.5Furthermore, as information on deaths before admission was gathered from relatives, these data were not as complete or possi- bly as accurate as they were for those admitted to hospi- tal.There is, however, no reason to believe that these missing data were associated with sex and therefore it is unlikely that they will bias the results.The addition of patients with missing data on medical treatment to the analysis made little change to the case fatality ratio, although this analysis required the removal of some variables from the model.No previous study has examined in detail the relation between sex and mortality before admission to hospital after an acute coronary event.Brett and Madans included deaths before admission in their long term survival study but did not perform separate analyses on this subgroup of patients.7Our study shows that women, despite a less favourable risk profile, have a lower case fatality before admission to hospital and therefore an increased chance of arriving in a coronary care unit.This may be explained by more men experiencing a sudden or early death leading to a lower risk cohort arriving in hospital.It has been suggested, however, that women have a longer delay in seeking
Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition
Authors: William T. Cefalu
Journal: Journal of Clinical Investigation (2014)

It is well known that glycemic control over time reduces microvascular and macrovascular complications in human subjects with type 2 diabetes. In addition, preclinical models of type 2 diabetes have demonstrated that long-term hyperglycemia exacerbates insulin resistance and reduces β cell function; therefore, therapies that reduce blood glucose levels are of great interest in not only controlling complications, but for restoring known defects in the pathogenesis of type 2 diabetes. Pharmacological inhibition of the sodium-glucose cotransporter 2 (SGLT2) reduces plasma glucose by limiting glucose absorption in the kidney and increasing glucose excretion in the urine. In this issue of the JCI, Merovci and colleagues and Ferrannini and colleagues independently report a paradoxical increase in endogenous glucose production in patients with type 2 diabetes following SGLT2 inhibition, despite an overall decrease in fasting plasma glucose. Together, these studies provide a unique insight into the effects of SGLT2 inhibition on whole body metabolism.
Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-α via the PI 3-kinase-Akt signaling pathway
Authors: Hirofumi Kawanaka, Michael K. Jones, Imre L. Szabo, Dolgor Baatar, Rama Pai, Kouji Tsugawa, Keizo Sugimachi, James I. Sarfeh, Andrzej S. Tarnawski
Journal: Hepatology (2002)

Activation of endothelial nitric oxide synthase (eNOS) in portal hypertensive (PHT) gastric mucosa leads to hyperdynamic circulation and increased susceptibility to injury. However, the signaling mechanisms for eNOS activation in PHT gastric mucosa and the role of TNF-α in this signaling remain unknown. In PHT gastric mucosa we studied (1) eNOS phosphorylation (at serine 1177) required for its activation; (2) association of the phosphatidylinositol 3-kinase (PI 3-kinase), and its downstream effector Akt, with eNOS; and, (3) whether TNF-α neutralization affects eNOS phosphorylation and PI 3-kinase-Akt activation. To determine human relevance, we used human microvascular endothelial cells to examine directly whether TNF-α stimulates eNOS phosphorylation via PI 3-kinase. PHT gastric mucosa has significantly increased (1) eNOS phosphorylation at serine 1177 by 90% ( P &lt; .01); (2) membrane translocation ( P &lt; .05) and phosphorylation ( P &lt; .05) of p85 (regulatory subunit of PI 3-kinase) by 61% and 85%, respectively; (3) phosphorylation ( P &lt; .01) and activity ( P &lt; .01) of Akt by 40% and 52%, respectively; and (4) binding of Akt to eNOS by as much as 410% ( P &lt; .001). Neutralizing anti-TNF-α antibody significantly reduced p85 phosphorylation, phosphorylation and activity of Akt, and eNOS phosphorylation in PHT gastric mucosa to normal levels. Furthermore, TNF-α stimulated eNOS phosphorylation in human microvascular endothelial cells. In conclusion, these findings show that in PHT gastric mucosa, TNF-α stimulates eNOS phosphorylation at serine 1177 (required for its activation) via the PI 3-kinase-Akt signal transduction pathway.
Sodium Channel Block With Mexiletine Is Effective in Reducing Dispersion of Repolarization and Preventing Torsade de Pointes in LQT2 and LQT3 Models of the Long-QT Syndrome
Authors: Wataru Shimizu, Charles Antzelevitch
Journal: Circulation (1997)

Background This study examines the contribution of transmural heterogeneity of transmembrane activity to phenotypic T-wave patterns and the effects of pacing and of sodium channel block under conditions mimicking HERG and SCN5A defects linked to the congenital long-QT syndrome (LQTS). Methods and Results A transmural ECG and transmembrane action potentials from epicardial, M, and endocardial or Purkinje cells were simultaneously recorded in an arterially perfused wedge of canine left ventricle. d -Sotalol was used to mimic LQT2, whereas ATX-II mimicked LQT3. d -Sotalol caused a preferential prolongation of the M cell action potential duration (APD 90 , 291±14 to 354±35 ms), giving rise to broad and sometimes low-amplitude bifurcated T waves and an increased transmural dispersion of repolarization (TDR, 51±15 to 72±17 ms). QT interval increased from 320±13 to 385±37 ms. ATX-II produced a preferential prolongation of the M cell APD 90 (280±25 to 609±49 ms) and caused a marked delay in the onset of the T wave and a sharp rise in TDR (40±5 to 168±40 ms). QT-, APD 90 -, and dispersion-rate relations were much steeper in the ATX-II than in the d -sotalol model. Mexiletine (2 to 20 μmol/L) dose-dependently abbreviated the QT interval and APD 90 of all cell types, more in the ATX-II than in the d -sotalol model, but decreased TDR equally in the two models. Mexiletine 2 to 5 μmol/L totally suppressed spontaneous torsade de pointes (TdP) and reduced the vulnerable window during which single extrastimuli could induce TdP in both models. Higher concentrations of mexiletine (10 to 20 μmol/L) totally suppressed stimulation-induced TdP. Conclusions Our results suggest that although pacing and sodium channel block are very effective in abbreviating the QT interval and TDR in LQT3, these therapeutic approaches may also be valuable in reducing the incidence of arrhythmogenesis in LQT2.
70 INTRAHEPATIC CHANGES IN BILE ACID COMPOSITION PROTECTS BSEP (ABCB11) KO MICE FROM HEPATIC INFLAMMATION IN METHIONINE CHOLINE DEFICIENT DIET INDUCED NASH
Authors: C.D. Fuchs, T. Claudel, E. Halilbasic, T. Stojakovic, M. Trauner
Journal: Journal of Hepatology (2013)
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.
Authors: J Jacob, J Przylepa, C Miller, G Kelsoe
Journal: The Journal of Experimental Medicine (1993)

In the murine spleen, germinal centers are the anatomic sites for antigen-driven hypermutation and selection of immunoglobulin (Ig) genes. To detail the kinetics of Ig mutation and selection, 178 VDJ sequences from 16 antigen-induced germinal centers were analyzed. Although germinal centers appeared by day 4, mutation was not observed in germinal center B cells until day 8 postimmunization; thereafter, point mutations favoring asymmetrical transversions accumulated until day 14. During this period, strong phenotypic selection on the mutant B lymphocytes was inferred from progressively biased distributions of mutations within the Ig variable region, the loss of crippling mutations, decreased relative clonal diversity, and increasingly restricted use of canonical gene segments. The period of most intense selection on germinal center B cell populations preceded significant levels of mutation and may represent a physiologically determined restriction on B cells permitted to enter the memory pathway. Noncanonical Ig genes recovered from germinal centers were mostly unmutated although they probably came from antigen-reactive cells. Together, these observations demonstrate that the germinal center microenvironment is rich and temporally complex but may not be constitutive for somatic hypermutation.
Are patients with abnormal cervical smears adequately managed?
Authors: J M Elwood, R E Cotton, J Johnson, G M Jones, J Curnow, M W Beaver
Journal: BMJ (1984)

The outcome was assessed for all 1062 women in Nottingham who had a first report of abnormal cervical cytology in 1981. Satisfactory follow up could be found for only 628 (59%) of them. For 275 (26%) one subsequent normal smear had been reported but no further follow up requested. For 43 (4%), no subsequent test, after the abnormal smear, had been requested by the patient9s general practitioner. Thirty patients (3%), 22 of whom had been tested at a special clinic, had not responded to a request for follow up. Even after extensive efforts we could not find the outcome in the remaining 86 (8%) of the patients. Adequate follow up of patients with abnormal cervical cytology is not being achieved. Improvements in the records systems and some changes in procedure should be made to reduce this problem.
Urological Management of the Meningomyelocele Patient
Authors: David A. Culp
Journal: JAMA (1970)

In 1964, Graf et al<sup>1</sup>analyzed a series of 50 cases with spina bifida and meningomyelocele and demonstrated that the ultimate prognosis of the patients who survived their early neurological problems depended upon the condition and function of the upper urinary tract and that the morphologic state and functional capacity of the upper urinary tract could be assessed by roentgenographic means. Furthermore, they demonstrated that diversion of urine from the lower urinary tract failed to prevent progressive, silent upper urinary tract changes that eventually lead to renal failure. In spite of the diversion of urine from the lower urinary tract, ureterectasis developed in 73% of the patients in the series, ureteral reflux in 61%, and reduction in renal function in 46%. After reviewing their findings they suggested that supravesical diversion of urine by ileal conduit was an effective corrective measure in selected cases. As a result of this study,
Estimating Divergence Time with the Use of Microsatellite Genetic Distances: Impacts of Population Growth and Gene Flow
Authors: Lev A. Zhivotovsky
Journal: Molecular Biology and Evolution (2001)

Genetic distances play an important role in estimating divergence time of bifurcated populations. However, they can be greatly affected by demographic processes, such as migration and population dynamics, which complicate their interpretation. For example, the widely used distance for microsatellite loci, (deltamu)2, assumes constant population size, no gene flow, and mutation-drift equilibrium. It is shown here that (deltamu)2 strongly underestimates divergence time if populations are growing and/or connected by gene flow. In recent publications, the average estimate of divergence time between African and non-African populations obtained by using (deltamu)2 is about 34,000 years, although archaeological data show a much earlier presence of modern humans out of Africa. I introduce a different estimator of population separation time based on microsatellite statistics, T(D), that does not assume mutation-drift equilibrium, is independent of population dynamics in the absence of gene flow, and is robust to weak migration flow for growing populations. However, it requires a knowledge of the variance in the number of repeats at the beginning of population separation, V(0). One way to overcome this problem is to find minimal and maximal bounds for the variance and thus obtain the earliest and latest bounds for divergence time (this is not a confidence interval, and it simply reflects an uncertainty about the value of V(0) in an ancestral population). Another way to avoid the uncertainty is to choose from among present populations a reference whose variation is presumably close to what it might have been in an ancestral population. A different approach for using T(D) is to estimate the time difference between adjacent nodes on a phylogenetic population tree. Using data on variation at autosomal short tandem repeat loci with di-, tri-, and tetranucleotide repeats in worldwide populations, T(D) gives an estimate of 57,000 years for the separation of the out-of-Africa branch of modern humans from Africans based on the value of V(0) in the Southern American Indian populations; the earliest bound for this event has been estimated to be about 135,000 years. The data also suggest that the Asian and European populations diverged from each other about 20,000 years, after the occurrence of the out-of-Africa branch.
Antinuclear antibodies in patients with scleroderma (systemic sclerosis) and in their blood relatives and spouses.
Authors: A J Barnett, L J McNeilage
Journal: Annals of the Rheumatic Diseases (1993)

OBJECTIVE--To test the postulate that there is a higher prevalence of antinuclear antibodies (ANAs) in serum samples from blood relatives and from spouses of patients with scleroderma than in control samples, and that this provides evidence for both genetic and environmental factors influencing autoimmunity in scleroderma. METHOD--Testing for ANAs was performed on 58 patients with scleroderma, 30 of their spouses, 74 first degree relatives, and 66 control subjects broadly age matched to the patients, their spouses, and about half of the relatives (siblings and parents). RESULTS--On the basis of an ANA titre of > 40 as positive, 12 (18%) of the controls, 55 (95%) of the patients, one (3%) of the spouses and five (7%) of the relatives would be classified as positive. Thirty seven (64%) of the patients had defined specificities (ACA, Scl 70, U1 (RNP)) but none of the controls, spouses, or relatives had antibodies of these specificities. CONCLUSION--These findings give no support to the postulate that environmental or genetic factors contribute to the ANAs in scleroderma.
Looking at the Dying Patient: The Ferdinand Hodler Paintings of Valentine Godé-Darel
Authors: Bernhard C. Pestalozzi
Journal: Journal of Clinical Oncology (2002)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.7.1948 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11919258 Looking at the Dying Patient: The Ferdinand Hodler Paintings of Valentine Godé-Darel Bernhard C. PestalozzixBernhard C. PestalozziSearch for articles by this author Show More From the Division of Oncology, Department of Internal Medicine, University Hospital, Zurich, Switzerland. https://doi.org/10.1200/JCO.2002.20.7.1948 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
Person-to-Person Transmission of<i>Staphylococcus aureus</i>
Authors: N. Joel Ehrenkranz
Journal: New England Journal of Medicine (1964)

THE number of Staphylococcus aureus organisms disseminated by different carriers and the extent to which they contaminate their environment and transmit infection to their contacts have been shown to vary widely. Nasal carriers with purulent skin lesions or respiratory viral infections have been described as being especially apt to transmit staphylococci1 , 2; yet carriers lacking these conditions have also been observed to cause considerable environmental contamination and to spread infection to contacts.3 Carriers whose nasal swabs yielded 105 or more Staph. aureus organisms in broth have been reported by White4 to disperse more of these organisms to the air and . . .
TCT-381 First Report of Acute and Short-term Outcomes from a Confirmatory (Cohort B) Study of Percutaneous Ventricular Restoration (PVR) therapy using the Parachute Device in Patients with Ischemic Dilated Heart Failure
Authors: Martyn Thomas, Marco Costa, Christoph Nienaber, Hüseyin Ince, Andrejs Erglis, William Abraham
Journal: Journal of the American College of Cardiology (2012)
UN body condemns Syria for use of lethal violence against protestors and for denial of access to medical treatment
Authors: J. Zarocostas
Journal: BMJ (2011)

The United Nations Human Rights Council condemned Syria on Friday 29 April for resorting to lethal violence in its intensified crackdown against antigovernment protestors and for denying access to medical treatment.

“The preponderance of information emerging from Syria depicts a widespread, persistent, and gross disregard for basic human rights by the Syrian military and security forces,” said Kang Kyung-wha, the UN’s deputy high commissioner for human rights.

She said that information gathered included reports of “the widespread use of live fire against protestors . . . torture of detainees . . . and attacks against medical personnel, facilities, and patients.”

In a special session the 47 member council adopted a resolution, by 26 votes to nine, that unequivocally condemned the killings and “the hindrance of access to medical treatment” …
Detection of psoriasin/S100A7 in the sera of patients with psoriasis
Authors: K.S. Anderson, J. Wong, K. Polyak, D. Aronzon, C. Enerbäck
Journal: British Journal of Dermatology (2009)

Background Psoriasis is a disease of dysregulated inflammation and epithelial hyperproliferation in the skin, involving both the innate and adaptive immune system. Psoriatic keratinocytes express high levels of psoriasin (S100A7), a small calcium‐binding protein.
FDA Modernization Act of 1997
Authors: Stuart L. Nightingale
Journal: JAMA (1998)

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