tbuckley/cabot-search huggingface dataset:
Occlusion of the Renal Artery Secondary to Acute or Remote Trauma
Authors: Steven H. Cornell
Journal: JAMA (1972)

Five patients with traumatic occlusion of the renal artery were seen during a three-year period. The injury was recent in four and remote in one. A traumatized kidney not visualized on the excretory urogram but showing no distortion of the collecting system on the retrograde pyelogram should be studied by renal arteriography. If the obstruction is incomplete, repair of the renal artery with restoration of normal blood flow might be possible. A severely ischemic kidney must be removed to prevent the development of infection and hypertension. The arteriogram should be examined for evidence of associated injury to the patient such as splenic or hepatic laceration.
EFFECTS OF ENZYMES IN SERUM ON CARBOHYDRATES AND THEIR RELATION TO BACTERIOLOGICAL TECHNIQUE
Authors: Carl Tenbroeck
Journal: The Journal of Experimental Medicine (1920)

It has been shown that enzymes in serum will change maltose, dextrin, and starch so that they will react as dextrose in media. These enzymes are destroyed by heating to 60 degrees C. for 15 minutes, but they are present in sera that have been refrigerated for as long as 18 months. The practice of using carbohydrate media containing unheated serum should be discouraged, and if it is used the possibility that the carbohydrate may be changed by the enzymes present must be considered.
Nephrotoxic Effects of Penicillamine
Authors: Robert G. Luke
Journal: JAMA (1968)

To the Editor:—  We were very interested in the paper, Nephrotoxic Effects of Penicillamine in Cystinuria ( 201 :698, 1967), as we have reported a similar experience in two patients receiving penicillamine ( J Urol , to be published).  In one patient, a 21-year-old woman, a protein leak of 6.4 gm/24 hr developed after 18 months on penicillamine regimen in a dosage of 1.8 gm/day. Proteinuria gradually lessened but disappeared only 30 months after stopping the drug. In the second patient, a 52-year-old man, proteinuria (1.6 gm/24 hr) developed after 29 months on penicillamine regimen in a dosage of 1.2 gm/24 hr. In this patient, because left nephrectomy and cystolithotomy had previously been required due to cystinuric calculi, and because he was unlikely to cooperate in a regimen of high fluid intake, the drug was continued; proteinuria of a similar degree persisted for ten months then gradually disappeared.  Thus when proteinuria occurs as
FURTHER OBSERVATIONS ON THE INABILITY TO TRANSMIT A RABBIT NEOPLASM BY CELL-FREE MATERIALS
Authors: Louise Pearce, James B. Murphy
Journal: The Journal of Experimental Medicine (1927)

It has not been possible to propagate a malignant neoplasm of the rabbit with cell-free filtrates, or desiccated tumor tissue or by the use of fluid media kept in contact with tumor tissue. These findings confirm the results of previous experiments carried out with early generations of the tumor. The existence of an agent distinct from the tumor cell which could initiate growth has not been demonstrated. The experiments bring out an essential biological difference between this mammalian neoplasm which is considered to be of epithelial origin and certain filtrable tumors of fowls which have been classified as sarcomata.
Computational Identification of miRNAs and Their Target Genes from Expressed Sequence Tags of Tea (Camellia sinensis)
Authors: G.R. Prabu, A.K.A. Mandal
Journal: Genomics Proteomics & Bioinformatics (2010)

Abstract MicroRNAs (miRNAs) are a newly identified class of small non-protein-coding post-transcriptional regulatory RNA in both plants and animals. The use of computational homology based search for expressed sequence tags (ESTs) with the Ambros empirical formula and other structural feature criteria filter is a suitable combination towards the discovery and isolation of conserved miRNAs from tea and other plant species whose genomes are not yet sequenced. In the present study, we blasted the database of tea (Camellia sinensis) ESTs to search for potential miRNAs, using previously known plant miRNAs. For the first time, four candidate miRNAs from four families were identified in tea. Using the newly identified miRNA sequences, a total of 30 potential target genes were identified for 11 miRNA families; 6 of these predicted target genes encode transcription factors (20%), 16 target genes appear to play roles in diverse physiological processes (53%) and 8 target genes have hypothetical or unknown functions (27%). These findings considerably broaden the scope of understanding the functions of miRNA in tea.
Intracameral Phenylephrine 1.5% for Prophylaxis against Intraoperative Floppy Iris Syndrome: Prospective, Randomized Fellow Eye Study
Authors: Ramón Lorente, Victoria de Rojas, Paula Vázquez de Parga, Claudio Moreno, Juan Varela, Maria Luisa Landaluce, Julia Méndez, Betty Lorente
Journal: Ophthalmology (2012)
Polyelectrolyte complexes of poly[(2-dimethylamino) ethyl methacrylate]/chondroitin sulfate obtained at different pHs: Preparation, characterization, cytotoxicity and controlled release of chondroitin sulfate
Authors: Letícia C. Bonkovoski, Alessandro F. Martins, Ismael C. Bellettini, Francielle P. Garcia, Celso V. Nakamura, Adley F. Rubira, Edvani C. Muniz
Journal: Journal of Controlled Release (2015)
Intracoronary β-Irradiation With a Liquid <sup>188</sup> Re-Filled Balloon
Authors: Martin Höher, Jochen Wöhrle, Markus Wohlfrom, Hartmut Hanke, Rainer Voisard, Hans H. Osterhues, Matthias Kochs, Sven N. Reske, Vinzenz Hombach, Jörg Kotzerke
Journal: Circulation (2000)

Background —Coronary irradiation is a new concept to reduce restenosis. We evaluated the feasibility and safety of intracoronary irradiation with a balloon catheter filled with 188 Re, a liquid, high-energy β-emitter. Methods and Results —Irradiation with 15 Gy at 0.5-mm tissue depth was performed in 28 lesions after balloon dilation (n=9) or stenting (n=19). Lesions included 19 de novo stenoses, 4 occlusions, and 5 restenoses. Irradiation time was 515±199 seconds in 1 to 4 fractions. There were no procedural complications. One patient died of noncardiac causes at day 23. One asymptomatic patient refused 6-month angiography. Quantitative angiography after intervention showed a reference diameter of 2.77±0.35 mm and a minimal lumen diameter of 2.36±0.43 mm. At 6-month follow-up, minimal lumen diameter was 1.45±0.88 mm (late loss index 0.57). Target lesion restenosis rate (&gt;50% in diameter) was low (12%; 3 of 26). In addition, we observed 9 stenoses at the proximal or distal end of the irradiation zone, potentially caused by the short irradiation segment and the decreasing irradiation dose at its borders (“edge” stenoses). The total restenosis rate was 46% and was significantly lower (29% vs 70%, P =0.042) when the length of the irradiated segment was more than twice the lesion length. Conclusions —Coronary irradiation with a 188 Re-filled balloon is technically feasible and safe, requiring only standard percutaneous transluminal coronary angioplasty techniques. The target lesion restenosis rate was low. The observed edge stenoses appear to be avoidable by increasing the length of the irradiated segment.
Idiotypes and Idiotypic Networks
Authors: Susan Burdette, Robert S. Schwartz
Journal: New England Journal of Medicine (1987)

THE central feature of the immune system is its diversity. We can appreciate that from the numerous variations in immunoglobulin molecules: a mouse weighing only an ounce has the capacity to make 100 million different antibodies.1 The advantage of such flexibility in a world of hostile microbes is self-evident. But not so obvious is the effect of antibody diversity on the immune system itself. Is the immune system a Janus, with one face scrutinizing antigens of the external environment and another monitoring its own variations? Does the very large number of antibody structures actually represent a private, internal code of . . .
Brief Report: Treatment of Chronic Inflammatory Bowel Disease in Glycogen Storage Disease Type Ib with Colony-Stimulating Factors
Authors: Thomas F. Roe, Thomas D. Coates, Daniel W. Thomas, John H. Miller, Vicente Gilsanz
Journal: New England Journal of Medicine (1992)

GLYCOGEN storage disease Type Ib is a rare hereditary metabolic disorder characterized by growth failure, hepatomegaly, hypoglycemia, lactic acidosis, and neutrophil deficiency.1 , 2 Except for the...
2012 ACCF/AHA/HRS Focused Update Incorporated Into the ACCF/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities
Authors: Andrew E. Epstein, John P. DiMarco, Kenneth A. Ellenbogen, N.A. Mark Estes, Roger A. Freedman, Leonard S. Gettes, A. Marc Gillinov, Gabriel Gregoratos, Stephen C. Hammill, David L. Hayes, Mark A. Hlatky, L. Kristin Newby, Richard L. Page, Mark H. Schoenfeld, Michael J. Silka, Lynne Warner Stevenson, Michael O. Sweeney, Cynthia M. Tracy, Andrew E. Epstein, Dawood Darbar, John P. DiMarco, Sandra B. Dunbar, N.A. Mark Estes, T. Bruce Ferguson, Stephen C. Hammill, Pamela E. Karasik, Mark S. Link, Joseph E. Marine, Mark H. Schoenfeld, Amit J. Shanker, Michael J. Silka, Lynne Warner Stevenson, William G. Stevenson, Paul D. Varosy, Jeffrey L. Anderson, Alice K. Jacobs, Jonathan L. Halperin, Nancy M. Albert, Mark A. Creager, David DeMets, Steven M. Ettinger, Robert A. Guyton, Judith S. Hochman, Frederick G. Kushner, E. Magnus Ohman, William Stevenson, Clyde W. Yancy
Journal: Circulation (2012)
Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel
Authors: Stephen Griffin, Corine StGelais, Ania M. Owsianka, Arvind H. Patel, David Rowlands, Mark Harris
Journal: Hepatology (2008)

Abstract The hepatitis C virus (HCV) p7 protein plays a critical role during particle formation in cell culture and is required for virus replication in chimpanzees. The discovery that it displayed cation channel activity in vitro led to its classification within the “viroporin” family of virus-coded ion channel proteins, which includes the influenza A virus (IAV) M2 protein. Like M2, p7 was proposed as a potential target for much needed new HCV therapies, and this was supported by our finding that the M2 inhibitor, amantadine, blocked its activity in vitro . Since then, further compounds have been shown to inhibit p7 function but the relationship between inhibitory effects in vitro and efficacy against infectious virus is controversial. Here, we have sought to validate multiple p7 inhibitor compounds using a parallel approach combining the HCV infectious culture system and a rapid throughput in vitro assay for p7 function. We identify a genotype-dependent and subtype-dependent sensitivity of HCV to p7 inhibitors, in which results in cell culture largely mirror the sensitivity of recombinant protein in vitro ; thus building separate sensitivity profiles for different p7 sequences. Inhibition of virus entry also occurred, suggesting that p7 may be a virion component. Second site effects on both cellular and viral processes were identified for several compounds in addition to their efficacy against p7 in vitro . Nevertheless, for some compounds antiviral effects were specific to a block of ion channel function. Conclusion: These data validate p7 inhibitors as prototype therapies for chronic HCV disease. (Hepatology 2008;48:1779-1790.)
Needles for Varicose Veins
Authors: H. Dodd
Journal: BMJ (1948)

advisable in the presence of acute allergic manifestations.Failure to find microfilariae in the blood does not exclude the diagnosis, as they may be very difficult to demonstrate in Loa loa.An annotation, in the Journal (July 3, p. 32) has recently drawn attention to the possibility of the successful treatment of filariasis by chemotherapy.-Weare, etc., G. MELTON.London, N.21.
Combined factor IX and protein C deficiency in a child: Thrombogenic effects of two factor IX concentrates
Authors: Claude Negrier, Jean Vial, Christine Vinciguerra, Micheline Berruyer, Marc Dechavanne
Journal: American Journal of Hematology (1995)

Abstract We have recently described an unusual situation which involved a combination of a factor IX and a protein C deficiency in a young child who presented, according to the bleeding tendency, as a hemophilia B patient in this particular hemophiliac, baseline prothrombin fragment F 1+2 levels were unexpectedly elevated and increased after an injection of a very high purity factor IX concentrate. This observation raised a question regarding the substitution schedule in the case of repeated injections of factor IX, since the thrombotic tendency has been a major concern with some factor IX concentrates. We monitored factor IX, prothrombin fragment F 1+2 and D‐dimer plasma levels before and during the 6 hr following the injection of an immunopurified factor IX concentrate. The results showed an increase in the F 1+2 levels after the factor IX injection, but an increase lower than previously observed with an ion‐exchange chromatography‐purified concentrate. Furthermore the F 1+2 level returned to baseline value 6 hr after administration. This factor IX concentrate seems to be best for use in the patient where repeated injections are involved (as employed during surgery). Moreover, the data point out the advantage of a monoclonal antibody‐purified factor IX concentrate over less purified concentrates in a specific situation, with regard to the thrombogenic risk.
Adverse drug reactions: who is to know?
Authors: M Cook, R E Ferner
Journal: BMJ (1993)

Clinical implications* Many patients with coronary artery disease suffer from intractable angina pectoris in spite of optimal medical and surgical therapy * Spinal cord stimulation has proved to be an effective method to relieve angina pectoris in these patients; the anti-anginal effect seems, from earlier studies, to be associated with a reduction in myocardial ischaemia * This study confirms that spinal cord stimulation has an anti-ischaemic effect in angina pectoris that can be induced by atrial pacing-this effect is probably mediated by a reduction in myocardial oxygen consumption.* Myocardial ischaemia during treatment with spinal cord stimulation gives rise to anginal pain-that is, the treatment does not conceal symptoms of myocardial ischaemia * Spinal cord stimulation seems to be a therapeutic possibility in patients with angina pectoris when conventional strategies of management have been exhausted increased tolerance to atrial pacing, improved myo- cardial lactate metabolism, and decreased magnitude and duration of ST segment depression at comparable pacing frequencies, suggesting antianginal and antiischaemic effects of the treatment.These effects seem to be related to a decrease in myocardial oxygen consumption.At the maximum pacing rate all patients experienced anginal pain, myocardial lactate extrac- tion changed to production, and the magnitude of ST segment depression and myocardial oxygen con- sumption increased to the same values as during control pacing, indicating that myocardial ischaemia during treatment with spinal cord stimulation gives rise to anginal pain.Thus, the treatment does not deprive the patient of a warning signal during myocardial ischaemia.We thank our medical statistician, Anders Oden, for expert professional advice and for careful and precise statistical calculations and for guidance regarding their interpretation.
Fatigue Syndrome-Reply
Authors: Stephen E. Straus
Journal: JAMA (1988)

<h3>In Reply.</h3> —The chronic fatigue syndrome should be considered only after other relevant diagnoses have been excluded. Dr Lehrer and Ms Hover suggest that chronic cocaine use be added to the list of excludable disorders. Having specifically inquired of over 140 patients with chronic fatigue regarding their histories of illicit drug use, I am left with the impression that cocaine use is not a feature of the population referred to me for study. Nonetheless, among other patient groups cocaine use may be more prevalent, and thus Dr Lehrer and Ms Hover's admonition to consider it is appropriate. There are differences between the presentation of patients with chronic cocaine abuse and that of patients with the chronic fatigue syndrome. While cocaine use is increasingly common among women, it remains most prevalent in men, unlike the chronic fatigue syndrome. Nasal sores or bleeding, chronic cough, vomiting, loss of consciousness, and seizures are
SIMILAR 3-YEAR-MORTALITY IN PATIENTS WITH STEMI AND NSTEMI FOR KNOWN AS WELL AS FOR NEWLY DIAGNOSED DIABETES: RESULTS OF THE SWEETHEART REGISTRY
Authors: Anselm K. Gitt, Andrea Papp, Jan Karcher, Steffen Schneider, Peter Bramlage, Ralf Zahn, Uwe Zeymer, Diethelm Tschoepe
Journal: Journal of the American College of Cardiology (2014)
Lung Cancer Screening at Any Price?
Authors: Victor R. Grann, Alfred I. Neugut
Journal: JAMA (2003)

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ABC of antenatal care. Abdominal pain in pregnancy.
Authors: G Chamberlain
Journal: BMJ (1991)

Inevitable miscarriage. Pain in the stomach brings a woman to her doctor's surgery early, especially when she is pregnant. In most such cases the problem is not serious, but all cases need careful assessment as some women will need an immediate opinion at the hospital, some can wait till the next day, and others can wait till the next antenatal clinic. Abdominal pain is diagnosed mostly by clinical means. The history and examination are most important, investigations being less helpful than in other branches of medicine. The use of ultrasonography by clinical gynaecologists has considerably improved the understanding of pelvic pathology. A vaginal transducer may give better images in early pregnancy than abdominal transducers; however, the laparoscope is still a major investigative tool for lower abdominal pain in early pregnancy. Under appropriate anaesthesia a good view of the pelvis and its organs clinches a diagnosis; in some cases treatment is also possible at the same time. Pain arises either from inside an organ, involving the covering visceral peritoneum or from later involvement of the parietal peritoneum. The visceral aspects of the pain are poorly localised as they are mediated by the autonomie nervous system. Once the parietal peritoneum is affected, however, impulses travel by the somatic route and localisation may be more specific. Nausea and vomiting occur early in many pelvic conditions as well as in normal pregnancy, which might confuse the picture. Abdominal distension is not usual unless the alimentary tract is involved secondarily; furthermore, it is masked in mid and late pregnancy by the enlarging uterus. Shock may occur if acute pain is accompanied by sudden deterioration in the woman's condition such as in real hypovolaemia due to blood loss at a ruptured ectopic pregnancy or in relative hypovolaemia after excessive autonomie stimulation from peritoneal irritation of an abruptio placentae. For the sake of analysis, in this article the commoner causes of abdominal pain in pregnancy are considered as occurring in either late or early pregnancy, but some conditions can occur in both. The causes will be considered under only one heading, which does not mean, however, that they do not occur in the other half of pregnancy.
An Honorarium Well Merited.
Authors: W. W. Kingsbury
Journal: JAMA (1889)

<h3>Dear Sir :</h3> —The enclosed slip is such a rare compliment paid to one of our profession that I think it deserves notice. It is as follows: Be it ordained by the Municipal Assembly of the City of St. Louis, as follows: <h3>Section 1.</h3> The sum of five hundred dollars is hereby appropriated from the fund to pay Dr. A. C. Bernays for medical attendance on Murty O'Sullivan, a member of the police force, from June to September, 1888, who was injured in discharge of police duty on June 26, 1888, and the Auditor is directed to draw his warrant on the Treasurer for the above amount and deliver the same to Dr. A. C. Bernays, taking his receipt in full. <h3>Section 2.</h3> There is hereby appropriated and set apart out of municipal revenue to pay Dr. A. C. Bernays the sum of five hundred dollars. Approved March 30, 1889. The
Close relation between endothelium-dependent flow-mediated dilation in coronary and brachial artery in human
Authors: B. Takase, T. Akima, A. Uehata, S. Katushika, K. Isojima, K. Arakawa, K. Satomura, A. Kurita, H. Nakamura
Journal: Journal of the American College of Cardiology (1998)
SOME THOUGHTS ON INEBRIETY.Read in the Section of Medical Jurisprudence, at the Forty-first Annual Meeting of the American Medical Association, Nashville, Tenn., May, 1890.
Authors: J. F. AXTELLE
Journal: JAMA (1890)

Fred C, æt. 37, came to this city from Nova Scotia twelve years ago, a bright, manly young fellow, and secured a situation as salesman in one of our leading dry-goods houses. He was liked by all who had dealings with him, and was advanced from time to time by his employers. Soon he got to going out evenings, would drink with a friend when asked, but did not care for it other wise. This went on for about two years; then he found that when he drank once he wanted more, and would keep it up for two or three days, be sick for a week, and would drink no more for six months. When on some special occasion he would again take a drink, he would then keep it up as before. About this time he became engaged to be married, but the parents of the young lady
Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a phase I/II study
Authors: Francesco Frassoni, Francesca Gualandi, Marina Podestà, Anna Maria Raiola, Adalberto Ibatici, Giovanna Piaggio, Mario Sessarego, Nadia Sessarego, Marco Gobbi, Nicoletta Sacchi, Myriam Labopin, Andrea Bacigalupo
Journal: The Lancet Oncology (2008)