Fatal Cinchophen Poisoning
Authors: LAWRENCE PARSONS
Journal: Annals of Internal Medicine (1932)

Article1 October 1932Fatal Cinchophen PoisoningReport of Six CasesLAWRENCE PARSONS, M. D., WARREN G. HARDING 2ND, M.D., L.R.C.P. and S. (Edin.)LAWRENCE PARSONS, M. D.Search for more papers by this author, WARREN G. HARDING 2ND, M.D., L.R.C.P. and S. (Edin.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-4-514 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous article we1reported four fatalities from the use of cinchophen. Three of the patients had been under a mail order treatment for chronic arthritis. All four cases exhibited subacute hepatic degeneration ("yellow atrophy"). Eleven similar cases studied at necropsy by others, presented analogous changes. Several cases subsequently reported, together with others that were overlooked in the preparation of the previous report, increase the total number of fatalities in the literature to thirty-two.1-20Of this number twenty-six have been autopsied. In all of these cases the essential pathological changes were limited to the liver. Recently we have observed...References1 PARSONSHARDING LWG: Cinchophen (Atophan) poisoning; report of four cases, Am. Jr. Med. Sci., 1931, clxxxi, 115-125. CrossrefGoogle Scholar2 CABOT RC: Case records of the Massachusetts General Hospital, case 11231, Boston Med. and Surg. Jr., 1925, cxcii, 1122. CrossrefGoogle Scholar3 WILLCOX WH: Atophan derivatives in rheumatism, Brit. Med. Jr., 1926, ii, 273-274. CrossrefGoogle Scholar4 WELLS CJ: Atophan derivatives in rheumatism, Brit. Med. Jr., 1926, ii, 759. CrossrefGoogle Scholar5 LANGDON-BROWN W: Atophan derivatives in rheumatism: a caution, Brit. Med. Jr., 1926, ii, 37. CrossrefGoogle Scholar6 HITZENBERGER K: Case report, Wien. klin. Wchnschr., 1927, xl, 205. Google Scholar7 SINGER S: Case Report, Wien. klin. Wchnschr., 1927, xl, 238-239. Google Scholar8 RAKE GW: A case of subacute yellow atrophy following taking of Atophan, Guy's Hosp. Rep., 1927, lxxvii, 229-237. Google Scholar9 LOEWENTHALMCKAYLOWE LJWAEC: Acute yellow atrophy of liver following administration of Atophan, Brit. Med. Jr., 1928, i, 592-593. CrossrefGoogle Scholar10 SUTTON DC: Acute yellow atrophy of liver following taking of cinchophen, Jr. Am. Med. Assoc., 1928, xci, 310-312. CrossrefGoogle Scholar11 WEIL P: Leberatrophie nach Atophanbehandlung? Ein Obergutachten, Med. Welt, 1928, ii, 257-259. Google Scholar12 LONDON LETTER: Jr. Med. Assoc., 1928, xc, 1229. Google Scholar13 MCVICARWEIR CSJF: Acute yellow atrophy, possibly due to poisoning by Atophan, Med. Clin. No. America, 1929, xii, 1526-1528. Google Scholar14 REICHLE HS: Toxic cirrhosis of liver due to cinchophen, Arch. Int. Med., 1929, xliv, 281-288. CrossrefGoogle Scholar15 ANDERSONTETER SDDP: Acute yellow atrophy of the liver following administration of oxyl iodide, Jr. Am. Med. Assoc., 1929, xciii, 93. CrossrefGoogle Scholar16 STACYVANZANT LJFR: Poisoning from cinchophen, Minnesota Med., 1930, xiii, 327-328. Google Scholar17 RABINOWITZ MA: Atrophy of the liver due to cinchophen preparations, Jr. Am. Med. Assoc., 1930, xcv, 1228-1233. CrossrefGoogle Scholar18 WALKER WG: Cinchophen and acute yellow atrophy of the liver, New England Jr. Med., 1931, cciv, 253-254. CrossrefGoogle Scholar19 BEAVERROBERTSON DCHE: The specific character of toxic cirrhosis observed in cinchophen poisoning; a review of five fatal cases, Am. Jr. Path., 1931, vii, 237-258. Google Scholar20 BOGEN E: Cinchophen poisoning, report of case, Cal. and Western Med., 1931, xxxv, 269. Google Scholar21 : Renton's Hydrocin tablets, Jr. Am. Med. Assoc., 1931, xcvi, 209-210. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAWRENCE PARSONS, M. D.; WARREN G. HARDING2ND, M.D., L.R.C.P. and S. (Edin.)Affiliations: Los Angeles, CaliforniaFrom the Department of Pathology, Los Angeles County General Hospital, Unit No. 1, and the Department of Pathology, School of Medicine, University of Southern California. Received for publication, Nov. 28, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Advantages of Hepatic Injury and Jaundice in Certain Conditions, Notably the Rheumatic DiseasesATHE ANALGESIC EFFECT OF HEPATITIS AND JAUNDICE IN CHRONIC ARTHRITIS, FIBROSITIS AND SCIATIC PAIN*PHILIP S. HENCH, M.D., F.A.C.P. 1 October 1932Volume 6, Issue 4Page: 514-517KeywordsArthritisAtrophyHospital medicineLiver ePublished: 1 December 2008 Issue Published: 1 October 1932 PDF downloadLoading ...