tbuckley/cabot-search huggingface dataset:
miR30a Inhibits LOX Expression and Anaplastic Thyroid Cancer Progression
Authors: Myriem Boufraqech, Naris Nilubol, Lisa Zhang, Sudheer Kumar Gara, Samira M. Sadowski, Amit Mehta, Mei He, Sean Davis, Jennifer Dreiling, John A. Copland, Robert C. Smallridge, Martha M. Quezado, Electron Kebebew
Journal: Cancer Research (2014)

Abstract Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies, but its genetic drivers remain little understood. In this study, we report losses in expression of the miRNA miR30a, which is downregulated in ATC compared with differentiated thyroid cancer and normal tissue. miR30a downregulation was associated with advanced differentiated thyroid cancer and higher mortality. Mechanistically, we found miR30a decreased cellular invasion and migration, epithelial–mesenchymal transition marker levels, lysyl oxidase (LOX) expression, and metastatic capacity. LOX was identified as a direct target of miR30a that was overexpressed in ATC and associated with advanced differentiated thyroid cancer and higher mortality rate. Consistent with its role in other cancers, we found that LOX inhibited cell proliferation, cellular invasion, and migration and metastasis in vitro and in vivo. Together, our findings establish a critical functional role for miR30a downregulation in mediating LOX upregulation and thyroid cancer progression, with implications for LOX targeting as a rational therapeutic strategy in ATC. Cancer Res; 75(2); 367–77. ©2014 AACR.
Do Condom Catheter Collecting Systems Cause Urinary Tract Infection?
Authors: David D. Hirsh, Victor Fainstein, Daniel M. Musher
Journal: JAMA (1979)

A study was undertaken to determine whether use of a condom catheter collection system (CCCS) is associated with urinary tract infection (UTI). No UTI developed in 79 episodes of CCCS use in patients who were cooperative or because of paralysis were unable to manipulate the collecting system (mean time per patient, 21.2 days; total number of patient days, 1,677). By contrast, in 15 patients who were identified prospectively as being uncooperative and who repeatedly manipulated the CCS, UTI developed in eight (53.3%) within a mean of 9.6 days. Urethral catheterization in cooperative patients during CCCS use was followed by development of UTI. Repeated interference with the proper use of CCCS and urethral catheterization during CCCS use are associated with an increased risk of UTI.
Vesicoureteral Reflux Detected among Patients with Nocturnal Enuresis
Authors: Yoshiyuki Tanaka, Akihiro Kawauchi, Kimihiko Yoneda, Yasuyuki Naitoh, Yutaka Yamao, Hiroshi Iwasaki, Yoichi Mizutani, Tsuneharu Miki
Journal: European Urology (2002)
Maternally Inherited Essential Hypertension Is Associated With the Novel 4263A&gt;G Mutation in the Mitochondrial tRNA <sup>Ile</sup> Gene in a Large Han Chinese Family
Authors: Shiwen Wang, Ronghua Li, Andrea Fettermann, Zongbin Li, Yaping Qian, Yuqi Liu, Xinjian Wang, Anna Zhou, Jun Qin Mo, Li Yang, Pingping Jiang, Andreas Taschner, Walter Rossmanith, Min-Xin Guan
Journal: Circulation Research (2011)

Despite maternal transmission of hypertension in some pedigrees, pathophysiology of maternally inherited hypertension remains poorly understood.To establish a causative link between mitochondrial dysfunction and essential hypertension.A total of 106 subjects from a large Chinese family underwent clinical, genetic, molecular, and biochemical evaluations. Fifteen of 24 adult matrilineal relatives exhibited a wide range of severity in essential hypertension, whereas none of the offspring of affected fathers had hypertension. The age at onset of hypertension in the maternal kindred varied from 20 years to 69 years, with an average of 44 years. Mutational analysis of their mitochondrial genomes identified a novel homoplasmic 4263A>G mutation located at the processing site for the tRNA(Ile) 5'-end precursor. An in vitro processing analysis showed that the 4263A>G mutation reduced the efficiency of the tRNA(Ile) precursor 5'-end cleavage catalyzed by RNase P. tRNA Northern analysis revealed that the 4263A>G mutation caused ≈46% reduction in the steady-state level of tRNA(Ile). An in vivo protein-labeling analysis showed ≈32% reduction in the rate of mitochondrial translation in cells carrying the 4263A>G mutation. Impaired mitochondrial translation is apparently a primary contributor to the reductions in the rate of overall respiratory capacity, malate/glutamate-promoted respiration, succinate/glycerol-3-phosphate-promoted respiration, or N,N,N',N'-tetramethyl-p-phenylenediamine/ascorbate-promoted respiration and the increasing level of reactive oxygen species in cells carrying the 4263A>G mutation.These data provide direct evidence that mitochondrial dysfunction caused by mitochondrial tRNA(Ile) 4263A>G mutation is involved in essential hypertension. Our findings may provide new insights into pathophysiology of maternally transmitted hypertension.
Wireless System Transfers Power to Deep-Tissue Microimplants
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Essential Lymphocyte Function Associated 1 (LFA-1): Intercellular Adhesion Molecule Interactions for T Cell–mediated B Cell Apoptosis by Fas/APO-1/CD95
Authors: Jin Wang, Michael J. Lenardo
Journal: The Journal of Experimental Medicine (1997)

B cells are susceptible to Fas ligand (FasL)+ CD4+ Th1 cell–mediated apoptosis. We demonstrate that blocking the interactions between lymphocyte function associated (LFA)-1 and intercellular adhesion molecule(ICAM)-1 and ICAM-2 completely suppresses Fas-dependent B cell lysis. Antibodies to CD2 and CD48 partially suppress B cell apoptosis, whereas anti-B7.1 and anti-B7.2 antibodies have no effect. Also, B cells from ICAM-1–deficient mice are resistant to FasL+ T cell–mediated death. Our results suggest that LFA-1/ICAM interactions are crucial for Th1 cell–mediated B cell apoptosis and may contribute to the maintenance of B cell homeostasis in vivo.
Ultrasonic Measurement of Left Ventricular Wall Motion in Acute Myocardial Infarction
Authors: KIYOSHI INOUE, HAROLD SMULYAN, SAKTIPADA MOOKHERJEE, ROBERT H. EICH
Journal: Circulation (1971)

The time-motion representation of the echogram was used to evaluate the left ventricular posterior wall motion in myocardial infarction. The left ventricular posterior wall echo was obtained in 10 normal subjects and 26 patients with chest pain admitted to a coronary care unit, including 11 with acute myocardial infarction (group 1), nine with old myocardial infarction (group 2), and six with chest pain of miscellaneous origin (group 3). The total amplitude of posterior wall excursion, left ventricular isometric contraction time, left ventricular systolic ejection time, and mean posterior wall velocity (ratio of posterior wall excursion to ejection time) were measured. By using the measurements of posterior wall excursion, mean posterior wall velocity, and isometric contraction time, group 1 patients were differentiated from those of groups 2 and 3 and from the normal subjects (all P &lt; 0.01). The data from patients in groups 2 and 3 were not statistically different from those of normal subjects. The measurements obtained by the time-motion curve of the left ventricular posterior wall echo appear to be of value in the bedside evaluation of acute myocardial infarction.
Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy
Authors: Chao Liang, Baosheng Guo, Heng Wu, Ningsheng Shao, Defang Li, Jin Liu, Lei Dang, Cheng Wang, Hui Li, Shaohua Li, Wing Ki Lau, Yu Cao, Zhijun Yang, Cheng Lu, Xiaojuan He, D W T Au, Xiaohua Pan, Bao-Ting Zhang, Changwei Lu, Hongqi Zhang, Kinman Yue, Airong Qian, Peng Shang, Jiake Xu, Lianbo Xiao, Zhaoxiang Bian, Weihong Tan, Zicai Liang, Fuchu He, Lingqiang Zhang, Aiping Lu, Ge Zhang
Journal: Nature Medicine (2015)
Tc-99m MIBI Accumulation in Remnant Thymus A Cause of False-Positive Interpretation in Parathyroid Imaging
Authors: AYSE MUDUN, MEHMET KOCAK, SEHER UNAL, SEMA CANTEZ
Journal: Clinical Nuclear Medicine (1995)

A 17-year-old boy, who was suspected of having hyperparathyroidism, was admitted for parathyroid imaging. Tc-99m pertechnetate Tc-99m MIBI subtraction scintigraphy was performed. A focal increased activity accumulation was observed visually after Tc-99m MIBI injection in the lower left lobe of the thyroid extending inferiorly, which was interpreted as parathyroid adenoma. At surgery, a left thyroidectomy was performed and no parathyroid abnormality was observed, but a 3 ± 2 ± 3 cm mass, which was thought to be a thymic remnant, was removed. Histopathologic examination of this specimen revealed an involuted thymic tissue. Three months after surgery, Tc-99m MIBI imaging was repeated and no activity accumulation was seen in the neck.
QUANTITATIVE TESTS FOR PROTEOLYSIS.
Authors: A. L. BENEDICT
Journal: JAMA (1900)

The first table herewith presented gives the results of investigations on students who were free from subjective and objective evidences of stomach trouble, except for some transient disturbances of function as noted. The test meal throughout this series consisted of 50 grams of dry bread, 5 grams of butter, and 250 cubic centimeters of cold water, taken as a noon meal and removed by siphonage from sixty to ninety minutes after the completion of the meal. In no instance were remnants of breakfast found. In eleven of the sixteen examinations, syntonin was either altogether absent or present in the merest trace. The maximum [ill] was 20/100 c.c. in 10 c.c. As the qualitative examinations showed some slight variations from the theoretic normal, it was with some surprise that the following facts were deduced: 1. The presence of a measurable quantity of syntonin, was not connected with a failure of free HCl.
The Human Herpesviruses: An Interdisciplinary Perspective
Authors: Robert F. Betts
Journal: JAMA (1982)

This text on the herpesviruses in man contains chapters originally given as presentations at the International Conference on Herpes Viruses held in Atlanta in March 1980. The topics represent all the relevant areas of interest, including the clinical spectrum of diseases, epidemiology of infection and disease, diagnostic measures including rapid viral diagnosis, prevention, and treatment. For the chapters with a clinical bent, a review of the historical information is undertaken and then more recent developments are highlighted. Less clinically relevant but equally important is information presented on the immunology (especially cellular immunology) of herpesviruses. In addition, topics of molecular and genetic features of these viruses and latency and oncogenesis are nicely developed, with greater focus directed at more recent developments. Tables and figures in all chapters help clarify the information. For each area covered, the four human herpesviruses are given individual chapters. In keeping with the limits of our knowledge,
Selective versus non-selective His bundle pacing
Authors: D. O. WILLIAMS, B. J. SCHERLAG, R. R. HOPE, N. EL-SHERIF, R. LAZZARA, P. SAMET
Journal: Cardiovascular Research (1976)

His bundle pacing was achieved in 10 anaesthetized open chest dogs by stimulation from bipolar electrode catheters positioned in the aortic root and right heart. Recordings were taken directly through plunge wires from the right atrium, high ventricular septum, and epicardial sites on the right and left ventricles. Six types of response were seen during A-V junctional stimulation: (1) low atrial pacing; (2) combined atrial and His bundle pacing; (3) His bundle pacing; (4) combined atrial, ventricular septal, and His bundle pacing; (5) combined septal and His bundle pacing; and (6) ventricular pacing. Pacing of the His bundle in combination with the atrium and/or ventricular septum is designated as non-selective, whereas stimulation of the His bundle alone is considered selective pacing. Nonselective His bundle pacing can be recognized from the surface leads by changes in onset and amplitude of the QRS with appreciable T-wave alterations. Although electrode position was an important determinant of the type of pacing achieved, a variety of patterns of stimulation resulted from variation in the modalities of the pacing stimulus, ie, polarity, intensity, and duration. Unless these factors are considered, selective His bundle pacing may not be achieved.
Invasive vs Conservative Management of Acute Coronary Syndromes
Authors: David J. Cohen
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A6.22 Specialised pro-resolving lipid mediators in chronic inflammation: a comparison between rheumatoid arthritis and osteoarthritis
Authors: HS Jónasdóttir, H Brouwers, JC Kwekkeboom, TW Huizinga, M Kloppenburg, RE Toes, M Giera, A Ioan-Facsinay
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> Inflammation is usually a self-resolving process. The resolution phase involves several cells and molecules that act in a coordinated manner to suppress inflammation, help clearance of apoptotic cells and restore tissue homeostasis. Among these molecules, the pro-resolving specialised lipid mediators (SPM) have emerged as biomarkers and potent mediators of the resolution process. We hypothesised that the underlying cause of chronic inflammation in Rheumatoid Arthritis (RA) and Osteoarthritis (OA)could be the failure of activating pro-resolving mechanisms, involving poly-unsaturated fatty acids (PUFA) and their biologically active metabolites. <h3>Methods</h3> To investigate this, we have collected synovial fluid from 20 RA and 33 OA patients. We measured more than 50 analytes in the cell-free supernatant, including SPM, their pathway markers and accompanying PUFA, using liquid chromatography combined with mass spectrometry (LC-MS/MS). To this end, we have set-up a novel analytical platform, characterised by a simplified work-up protocol and high-throughput capabilities, making it particularly suitable for clinical studies. Moreover, we have quantified and characterised the cellular infiltrate using flow cytometry and the appropriate combination of antibodies directed against cell surface markers. <h3>Results</h3> By using as little as 40 µL of synovial fluid, we could demonstrate the presence of significant amounts of 5-HETE; 12-HETE; 15-HETE; 10S,17S-diHDHA; PGE<sub>2</sub>; 17-HDHA, a series of other hydroxylated analytes and a number of PUFA in synovial fluid of both patient groups. Remarkably, analyses of lipid mediator concentrations revealed higher levels of 12-HETE, 17-HDHA and the pro-resolving 10S,17S-diHDHA in OA versus RA patient samples, indicating a stronger activation of pro-resolving pathways in OA than in RA. Analyses of the cellular infiltrate indicated that in general, less infiltrating cells were found in OA than in RA and the majority of the infiltrating cells were monocytes and neutrophils. The number of monocytes correlated with the number of neutrophils in both diseases, suggesting no specific recruitment of a certain cell-type. Interestingly, we found a strong negative correlation between numbers of infiltrating cells and the concentration of 17-HDHA in the pooled RA and OA samples, as well as the individual disease samples, suggesting a possible biological role for this lipid in cell migration blockage. <h3>Conclusion</h3> These data indicate that both inflammatory and pro-resolving pathways are activated in RA and OA synovial fluid. However, the level of inflammation is less in OA than in RA and this could be explained by the presence of higher levels of SPM in OA compared to RA.
NICE does consider patient views
Authors: M. Kelson, C. Longson, P. Littlejohns
Journal: BMJ (2009)

Speight and Reaney’s article suggests that the National Institute for Health and Clinical Excellence (NICE) does not take patients’ views into account.1 A cursory review of its website and process and technical manuals shows that the authors are wrong and their conclusions based on factual inaccuracies.2 3

NICE uses a …
TCRB gene rearrangements in childhood and adult precursor-B-ALL: frequency, applicability as MRD-PCR target, and stability between diagnosis and relapse
Authors: V H J van der Velden, M Brüggemann, P G Hoogeveen, M de Bie, P G Hart, T Raff, H Pfeifer, S Lüschen, T Szczepański, E R van Wering, M Kneba, J J M van Dongen
Journal: Leukemia (2004)
Effects of Treatment With the Antioxidant α-Lipoic Acid on Cardiac Autonomic Neuropathy in NIDDM Patients: A 4-month randomized controlled multicenter trial (DEKAN Study)
Authors: Dan Ziegler, Helmut Schatz, Frank Conrad, F Arnold Gries, Heinz Ulrich, Gerhard Reichel
Journal: Diabetes Care (1997)

OBJECTIVE To evaluate the efficacy and safety of oral treatment with the antioxidant alpha-lipoic acid (ALA) in NIDDM patients with cardiac autonomic neuropathy (CAN), assessed by heart rate variability (HRV). RESEARCH DESIGN AND METHODS In a randomized, double-blind placebo-controlled multicenter trial (Deutsche Kardiale Autonome Neuropathie [DEKAN] Study), NIDDM patients with reduced HRV were randomly assigned to treatment with daily oral dose of 800 mg ALA (n = 39) or placebo (n = 34) for 4 months. Parameters of HRV at rest included the coefficient of variation (CV), root mean square successive difference (RMSSD), and spectral power in the low-frequency (LF; 0.05–0.15 Hz) and high-frequency (HF; 0.15–0.5 Hz) bands. In addition, cardiovascular autonomic symptoms were assessed. RESULTS Seventeen patients dropped out of the study (ALA n = 10; placebo n = 7). Mean blood pressure and HbA1 levels did not differ between the groups at baseline and during the study, but heart rate at baseline was higher in the group treated with ALA (P &amp;lt; 0.05). RMSSD increased from baseline to 4 months by 1.5 ms (−37.6 to 77.1) [median (minimum-maximum)] in the group given ALA and decreased by −0.1 ms (−19.2 to 32.8) in the placebo group (P &amp;lt; 0.05 for ALA vs. placebo). Power spectrum in the LF band increased by 0.06 bpm2 (−0.09 to 0.62) in ALA, whereas it declined by −0.01 bpm2 (−0.48 to 1.86) in placebo (P &amp;lt; 0.05 for ALA vs. placebo). Furthermore, there was a trend toward a favorable effect of ALA versus placebo for the CV and HF band power spectrum (P = 0.097 and P = 0.094 for ALA vs. placebo). The changes in cardiovascular autonomic symptoms did not differ significantly between the groups during the period studied. No differences between the groups were noted regarding the rates of adverse events. CONCLUSIONS These findings suggest that treatment with ALA using a well-tolerated oral dose of 800 mg/day for 4 months may slightly improve CAN in NIDDM patients.
Complications of Laparoscopic Surgery
Authors: Larry C. Carey
Journal: JAMA (1995)

<i>Complications of Laparoscopic Surgery</i>joins a rapidly increasing list of contributions on minimally invasive operations. The title is slightly inaccurate, since thorascopic procedures are also included. The text is generally well illustrated, and many of the operative photographs are clearer and more interpretable than one is accustomed to seeing in books on minimally invasive procedures. The opening chapter on general considerations describes credentialing guidelines. This remains an issue, particularly as the dimension of minimally invasive operations expands. We struggle with how to introduce new procedures and how to credential people to do them. While the suggestions presented are logical, they do not address the problem of "who gets to do the first." The section on complications of pneumoperitoneum is quite good. The authors have performed rather extensive physiologic studies. No reference is made to the effect of gasless procedures, which seem to be slowly attracting interest. Discussion of the risks
Under-reporting and case fatality estimates for emerging epidemics
Authors: K. E. Atkins, N. S. Wenzel, M. Ndeffo-Mbah, F. L. Altice, J. P. Townsend, A. P. Galvani
Journal: BMJ (2015)

Using the example of Ebola, this article highlights the problems of using population level data to estimate case fatality rates in epidemicsThe case fatality risk (CFR) is the probability that an infection results in death.For an emerging infectious disease, CFR is a vital metric to assess clinical severity.In this paper, we highlight methodological considerations fundamental to calculations of CFR during an ongoing epidemic.Ignoring information biases inherent to population level data may lead to inaccurate estimates of CFR, especially during the nascent phase of an epidemic.The epidemic of Ebola virus disease in west Africa provides an ideal case study both because the high death rate is a pressing international concern and because many CFR estimates have neglected to account for these biases, leading to inaccurate quantification.