tbuckley/cabot-search huggingface dataset:
Impairment of activities of daily living and incident heart failure in community‐dwelling older adults
Authors: C. Barrett Bowling, Gregg C. Fonarow, Kanan Patel, Yan Zhang, Margaret A. Feller, Xuemei Sui, Steven N. Blair, Kannayiram Alagiakrishnan, Inmaculada B. Aban, Thomas E. Love, Richard M. Allman, Ali Ahmed
Journal: European Journal of Heart Failure (2012)
Functional characteristics of Peyer's patch cells. III. Carrier priming of T cells by antigen feeding.
Authors: M F Kagnoff
Journal: The Journal of Experimental Medicine (1975)

Peyer's patch T cells may serve an important role in the interaction of the host with intraluminal gut antigens. Studies presented in this paper demonstrate that T cells in murine Peyer's patches can be carrier primed for helper function in the induction of an antihapten response by feeding antigen. Carrier priming was assessed by measuring the ability of Peyer's patch cells from mice fed heterologous erythrocytes to enhance an antitrinitrophenyl (TNP) response in vitro when added to normal Peyer's patch cells cultured with TNP coupled to the erythrocyte used for feeding. Priming of T helper cells in Peyer's patches was antigen specific and occurred when erythrocytes were administered orally but not when erythrocytes were injected intravenously or intraperitoneally. Murine Peyer's patches are naturally deficient in a cooperating accessory adherent cell type(s) required for B-cell induction to humoral antibody synthesis in vitro and antigen feeding does not result in significant induction of Peyer's patch B cells to humoral antibody synthesis in vivo. Since Peyer's patch T cells can be carrier-antigen primed for helper function in the absence of B-cell induction to humoral antibody synthesis, these studies may indicate that T-cell priming is less dependent than B-cell induction on cooperating accessory adherent cells.
A8.37 The role of microRNA-146a in inflammatory Arthritis
Authors: Saferding Victoria, Goncalves Alves Eliana, Puchner Antonia, Niederreiter Birgit, Kreindl Roman, Sahin Emine, Smolen Joseph, Redlich Kurt, Blüml Stephan
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> MicroRNA (MiR)146a is a key regulator of the innate immune response and has also been shown to suppress cancer development in myeloid cells. Elevated expression of miR-146a has been detected in synovial tissue of rheumatoid arthritis patients, but its function is not clear yet. Thus the role of miR-146a in inflammatory arthritis needs to be clarified. <h3>Materials and Methods</h3> We induced K/BxN serum transfer arthritis in wild type and miR-146a<sup>-/-</sup>mice. As a second inflammatory arthritis model we crossed miR-146a deficient into hTNFtg mice. Disease severity was assessed clinically and histologically in both arthritis models. Serum cytokine levels were measured by Elisa. <h3>Results</h3> Absence of miR-146a leads to increased clinical signs of the induced serum transfer arthritis. In line, higher serum levels of the proinflammatory cytokines IL12 and TNF were measured in miR146a deficient mice compared to wt mice. When we crossed miR-146a<sup>-/-</sup>mice into hTNFtg mice, while detecting no clinical difference between hTNFtg and miR146a/hTNFtg mice, we found a significant increase in synovial inflammation. Even more striking, miR146a/hTNFtg mice displayed a more than twofold increase in local bone destruction and number of osteoclasts in the tarsal joints of the mice. Of note, in vitro osteoclast generation was reduced in miR146a<sup>-/-</sup> mice. <h3>Conclusion</h3> Data from these two arthritis models reveal a negative regulatory role of the miR-146a in inflammatory arthritis. Mice lacking miR-146a are clinically worse than their wild type counterparts with concomitant higher proinflammatory cytokine production in serum transfer arthritis. In addition, microRNA 146a has important anti-erosive properties in TNF-driven local bone destruction and osteoclastogenesis, as mice lacking this microRNA display highly increased joint destruction compared to WT. These results identify an important anti-inflammatory role of miR-146a, which might possibly be exploited for therapeutic purposes.
Cancer Seeding From Needle Biopsy
Authors: John B. Janis
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I have noticed two articles reporting liver biopsy tract seeding, and the rarity of this occurrence.<sup>1,2</sup> We have also had a case of a 54-year old man with carcinoma of the left portion of the colon. Needle biopsy of liver was performed April 3, 1967. A troublesome hemorrhagic papilloma began growing at the skin puncture site. The pathology report on this excised mass (Nov 17) was metastatic carcinoma. Apparently, seeding after liver biopsy is not so rare.
Universities face higher costs during transition to open access model for research findings, conference told
Authors: M. Limb
Journal: BMJ (2013)

The transition to an open access model for published research findings risks being hugely wasteful of UK public funds unless the government changes its approach, a conference has heard.

Adrian Bailey, chairman of the House of Commons’ Business, Innovation and Skills Committee and Labour MP for West Bromwich West, who supports open access, said, “The process now underway disproportionately benefits publishers.”

He said that universities and research bodies, whose budgets were already stretched, would face higher costs meeting the change in publishers’ business models.

Bailey was speaking in London at a seminar on implementing open access policy, held on Tuesday …
Efficacy of Holter Monitors
Authors: Scott Kinlay
Journal: Annals of Internal Medicine (1996)

Letters15 October 1996Efficacy of Holter MonitorsScott Kinlay, MD and James W. Leitch, MBBSScott Kinlay, MDBrigham and Women's Hospital, Boston, MA 02115John Hunter Hospital, New South Wales 2310, AustraliaSearch for more papers by this author and James W. Leitch, MBBSBrigham and Women's Hospital, Boston, MA 02115John Hunter Hospital, New South Wales 2310, AustraliaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-8-199610150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Lantz's comments on the utility of Holter monitoring raise several issues that deserve comment. Compared with our study, his observations showed a higher rate of clinically significant arrhythmias, probably due to the different populations studied (for example, persons with documented arrhythmias) or perhaps to different definitions of significant arrhythmias (length of consecutive beats and type of arrhythmia).Both studies found that Holter monitoring can lead to confusion in the diagnosis and treatment of patients with cardiac arrhythmias. In our study, many of the arrhythmias recorded by Holter monitoring during symptoms were nonspecific and would not require specific ...REFERENCE1. Klein GJ, Gersh BJ, Yee R. Electrophysiological testing: the final court of appeal for diagnosis of syncope? Circulation. 1995; 92:1332-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Scott Kinlay, MD; James W. Leitch, MBBSAffiliations: Brigham and Women's Hospital, Boston, MA 02115John Hunter Hospital, New South Wales 2310, Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1996Volume 125, Issue 8 Page: 698 Keywords Arrhythmia Clinical trials Electrophysiological techniques Observational studies Patients Population statistics Quality of life Tachycardia ePublished: 15 August 2000 Issue Published: 15 October 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Expanding spectrum of the association between Type 1 Gaucher disease and cancers: A series of patients with up to 3 sequential cancers of multiple types—Correlation with genotype and phenotype
Authors: Sarah M. Lo, Philip Stein, Sean Mullaly, Michael Bar, Dhanpat Jain, Gregory M. Pastores, Pramod K. Mistry
Journal: American Journal of Hematology (2010)

In Gaucher disease (GD), inherited deficiency of lysosomal glucocerebrosidase due to mutations in GBA1 gene results in accumulation of glucosylceramide in tissue macrophages, systemic macrophage activation, and a complex multisystemic phenotype. We and others have reported an increased risk of multiple myeloma and other malignancies in non-neuronopathic Type 1 GD (GD1). Here, we describe a subset of GD1 patients with multiple malignancies. In our cohort of 403 patients with GD1, nine patients (2.2%) developed two or three different types of cancers either consecutively or simultaneously. Patients were characterized by age at diagnosis of GD1, GBA1 genotype, disease severity, age at cancer diagnosis, enzyme replacement therapy (ERT) status, and splenectomy status. Of the nine patients, six developed two types of malignancies and three had three cancers each. Overall, the hematologic malignancies comprised lymphoma/leukemia (4) and multiple myeloma (4). Nonhematologic malignancies included colon (2), lung (2), thyroid (2), and prostate cancer (1). Of the seven patients who received ERT, the first cancer was diagnosed before initiation of ERT in all but one. Asplenic patients were more likely to have single or multiple cancers compared with patients with intact spleens (P < 0.0072 and P < 0.0203, respectively). Our data strengthen the association of GD1 and cancer and suggest that patients may be at risk of developing multiple malignancies. We found an association between splenectomy and multiple cancers in GD1. It will be of interest to determine whether timely ERT and declining rates of splenectomy will translate into declining rates of multiple and single cancers.
Rapid HLA-DQB1 Genotyping for Four Alleles in the Assessment of Risk for IDDM in the Finnish Population
Authors: Jorma Ilonen, Helena Reijonen, Elja Herva, Minna Sjöroos, Antti Iitiä, Timo Lövgren, Riitta Veijola, Mikael Knip, Hans K Åkerblom
Journal: Diabetes Care (1996)

OBJECTIVE To study the effectiveness of MHC genotyping in the assessment of risk for IDDM based on the identification of alleles that are significantly associated with risk for IDDM (DQB1 *0302 and *0201) and protection from it (DQB1 *0602/*0603 and *0301). RESEARCH DESIGN AND METHODS A long series of 649 index cases of IDDM, together with their healthy siblings and 756 healthy blood donors, was collected in Finland. The samples were analyzed using a large-scale assay procedure that was developed for rapid screening purposes. The method utilizes time-resolved fluorometry to detect the hybridization of lanthanide-labeled allele-specific oligonucleotide probes with amplified gene product. RESULTS A total of 61.9% of IDDM index cases had high risk (DQB1 *0201/*0302) or moderate risk (DQB1 *0302/x [x meaning DQB1 *0302 or a nondefined allele]) genotypes compared with 14.3% of the reference population. In patients and control subjects, the frequencies of low risk genotypes were 28.0 and 22.1%, respectively, and those of decreased risk genotypes, 10.0 and 63.6%. The relative risk of a *0201/*0302 genotype was 53.5 (31.1–92.8) compared with the decreased risk genotypes (63.6% of controls). The graded risk estimation was equally efficient in assessing the risk of IDDM in siblings of child with IDDM. CONCLUSION The near-automatic typing procedure developed is attractive for large-scale screening projects, such as diabetes prevention and intervention trials.
Abstract 5246: The role of mir-21 and Let-7a in HMGA2 associated colorectal cancer pathogenesis with different APC/k-ras status
Authors: Ya-Wen Cheng, I-Chien Chen
Journal: Cancer Research (2014)

Abstract Colorectal cancer (CRC) is one of the leading causes of cancer death in both the Western world and Taiwan. Although CRC can be inherited, most CRCs are sporadic. The possible causes of colorectal cancer include a high fat diet, low fiber intake, obesity and sedentary lifestyle. A relatively limited number of oncogenes and tumor-suppressor genes_most prominently the APC, KRAS, and p53 genes are mutated in a sizeable fraction of CRCs. Even though numerous genes have been reported to be associated with tumorigenesis in CRC, only a few of them have been validated and used as biomarkers for predicting metastasis and treatment response in clinical applications. Our published paper showed that overexpression of high-mobility group AT-hook 2 (HMGA2) is associated with metastasis and unequivocally occurred in parallel with reduced survival rates of patients with CRC, and thus HMGA2 may potentially serve as a biomarker for predicting aggressive CRC with poor survivability and as an indicator of better response to radiotherapy. The Let-7a miRNA is a tumor suppressing miRNA that targets oncogenes, including HMGA2. Previous reports show that Let-7a miRNA may regulate miR-21 expression in cholesteatoma. The benign nature of cholesteatoma may be due to a balance between Let-7a and miR-21. The miR-21 has oncogene-like activity and is highly expressed in several types of cancers. Our present study also found that patients with high miR-21 expression had poor survival. In this study, we demonstrated the association of mir-21 and Let-7a in HMGA2 regulation in the pathogenesis of colorectal cancer and how the expression of these genes is associated with the clinical outcomes and radiotherapy response of CRC patients. Citation Format: Ya-Wen Cheng, I-Chien Chen. The role of mir-21 and Let-7a in HMGA2 associated colorectal cancer pathogenesis with different APC/k-ras status. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5246. doi:10.1158/1538-7445.AM2014-5246
A piece of my mind. ...for my father
Authors: K. J. Awan
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reduced newborn mononuclear cell production of interleukin-10 (IL-10) is associated with wheezing during RSV infections
Authors: Gregory Daniel Brooks, Patricia A Meyer, Kelly S Anklam, Kathy A Roberg, Kiva J Adler, Stephanie H Gilbertson-White, Kirstin T Carlson-Dakes, Douglas F Dasilva, Sarah A Ellerman-Sund, Abhik Bhattacharya
Journal: Journal of Allergy and Clinical Immunology (2002)
A delicate gesture
Authors: R. K. James
Journal: BMJ (2013)

A magnificent bunch of flowers is brought to my office, paraded through the waiting room of afternoon patients, a glorious ensemble of delicate tulips and petals overflowing with thanks. Pride swells as I receive them.

I am a new registrar to the practice, and I have stumbled my way through my first few months. My trainer is always encouraging, but this …
Transthoracic echocardiography using native tissue harmonic imaging: diagnostic alternative to transesophageal echocardiography in patients with suspected infective endocarditis
Authors: Fabio Chirillo, Alessandra Pedrocco, Andrea Bruni, Oscar Totis, Alessandro De Leo, Roberto Zecchel, Paolo Stritoni
Journal: Journal of the American College of Cardiology (2002)
Breast feeding and atopic eczema.
Authors: D J Atherton
Journal: BMJ (1983)

Breast feeding and atopic eczemaGenerally mild and transient, atopic eczema may be one of the most agonising of all diseases.Its incidence appears to be rising alarmingly in Britain: 12 3`, of a group of 12 555 children born in a single week in 1970 were reported by their parents to have had atopic eczema by the age of 5 years,' more than twice the proportion reported in a similar study 12 years previously.The pathogenesis of atopic eczema has not been established, though dietary factors play an important causal part, at least in early childhood.2The mechanism by which foods can exacerbate the disease is unknown, but allergy is widely believed to be the most likely explanation.Alternatively it may be an entirely metabolic disorder, the associated im- munological disturbances being merely epiphenomena.Certainly susceptibility to the disease is, to a great extent, inherited.Current data suggest that a history of any atopic disease in one parent roughly doubles a child's risk, and such a history in both parents doubles it again.3The concordance rate of 15", for monozygotic twins compared with just 4°" for dizygotic twins both confirms the genetic contribution and highlights the crucial role of environmental influences.4
Conference on Indications for Tonsillectomy and Adenoidectomy-Reply
Authors: Terence S. Carden
Journal: JAMA (1979)

I respect Dr Paradise and associates in their commitment to conduct scientific studies in an effort to resolve this issue. While the question of whether this should be done in one institution or in many centers may be important to those researchers actively involved in the issue, only the conclusions and their validity are of concern to the practicing physician. Unfortunately, these authors failed to appreciate the major thrust of my COMMENTARY, which was the difficulty—virtual impossibility—of designing a study that will win universal acceptance of its conclusions. If Dr Paradise and colleagues had been present for the major deliberations of the "consensus conference," they would have appreciated how much diversity of opinion existed among the blue-ribbon panel convened to arrive at a consensus on the issue. The panel had before it a number of positive recommendations for a nationwide study of the issue, recommendations that Paradise et
Perforation of the Bowel in the Newborn as a Complication of Exchange Transfusion
Authors: R. LE. Orme, S. M. Eades
Journal: BMJ (1968)

Spontaneous perforation of the bowel without evidence of intestinal obstruction is reported in six infants who had exchange transfusions for rhesus incompatibility, and in a seventh who had prolonged intravenous fluids via the umbilical vein. The pathological findings resemble those found in acute necrotizing enterocolitis in adults, which is known to be associated with arterial hypotension. The cause in these infants may also be due to a period of hypotension during the transfusion, and hypoxia and superimposed infection may also play an important part.
Pulmonary Tumor-Embolism from Intravascular Osteosarcoma Demonstrated by Bone Scintigraphy
Authors: C A HOEFNAGEL, H R MARCUSE, R SOMERS
Journal: Clinical Nuclear Medicine (1982)

Accumulation of Tc-99m MDP was noted in the lung of a patient with osteosarcoma and attributed to tumor embolism because of persistent evidence of pulmonary embolism on ventilation/ perfusion imaging and on normal chest x-ray and because of histologically proven intravascular growth of a recurrence of osteosarcoma in the left leg. The role of bone imaging in staging and follow-up of osteosarcoma is underlined.
Could universal health care coverage restrict access? The mixed effects of universal coverage on minorities' receipt of obstetric care in northern Thailand
Authors: Stephanie M Koning
Journal: The Lancet Global Health (2014)

BackgroundUnequal access to safe obstetric services is still a problem worldwide. I examine maternal characteristics associated with place of childbirth and the effect of Thailand's 2001 Universal Health Care Coverage (UHCC) Plan on women's access to and use of hospital-based obstetric services.MethodsI analysed household data from a sample of 13 534 women included in the UNESCO Highland Peoples Survey 2010, a survey of Thai-Burma border villages. I contextualised and triangulated statistical findings with relation to interviews I conducted with highland women and Thai health officials in 2009. With hierarchical logistic regression, I compared women's use of obstetric-based services by their ethnic group, education, language, and citizenship, overall, and before and after the UHCC plan was introduced.FindingsWomen's odds of having given birth in a hospital were significantly lower (p<0·0001) by (unadjusted model) 80% if they are a highland ethnic minority, and (adjusted model) 64% if they do not have citizenship, 68% if they have not had any schooling (compared with having finished upper secondary school), 27% if Thai is not spoken at home, and 47% if a minority language is spoken at home. Although women are generally more likely to have given birth in hospitals after the UHCC plan, nearly all inequalities between subgroups widened after the policy change. Interviews showed that although the UHCC generally reduced health-care-related costs, it imposed tighter restrictions on public insurance coverage and hospital spending, which resulted in unequal benefits to certain subpopulations.InterpretationDespite its commitment to expanding universal health care, Thailand has not eliminated all barriers to providing equal access to obstetric care services. These findings show the mixed effects of national universal health-care coverage plans.FundingThe British Embassy-Bangkok, the Canadian International Development Agency, pre-doctoral National Research Service Award Training Grant (T32 HS00023, PI: Smith), and National Institute of Child Health and Human Development Training Grant (T32 5T32AG000129-25, PD: Palloni).
Legendary Disseminated Intravascular Coagulation
Authors: Richard D. Smith
Journal: JAMA (1976)

To the Editor.—  Since Snow White and the Seven Dwarfs was last released for viewing seven years ago, considerable medical progress has occurred. The wicked stepmother, after formulating and preparing the apple, states  breath will grow short and her blood will congeal, and I will be fairest in the land! The efficacy of this pharmaceutical combination is well known and suggests that Snow White was one of the earliest surviving cases of disseminated intravascular coagulation. Still to be determined is which of the phlogistic agents used was the active ingredient or whether this was a particularly fortuitous drug combination. Important questions remain unanswered, however. Were other life-support procedures employed? How long did the state of suspended consciousness last?  The therapeutic efficacy of the kiss has been known for centuries, but this is the first known instance of the dramatic cure of such a devastating disease by a putative prince.