tbuckley/cabot-search huggingface dataset:
Commitment Devices to Improve Unhealthy Behaviors—Reply
Authors: Todd Rogers, Katherine L. Milkman, Kevin G. Volpp
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Respiratory inductance plethysmography in healthy infants: a comparison of three calibration methods
Authors: K.A. Poole, J.R. Thompson, H.m Hallinan, C.s Beardsmore
Journal: European Respiratory Journal (2000)

Respiratory inductance plethysmography (RIP) measures respiration from body surface movements. Various techniques have been proposed for calibration in order that RIP may be used quantitatively. These include calculation of the proportionality constant of ribcage to abdominal volume change (K). The aims of this study were to 1) establish whether a fixed value of K could be used for calibration, and 2) compare this technique with multiple linear regression (MLR) and qualitative diagnostic calibration (QDC) in normal healthy infants. Recordings of pneumotachograph (PNT) flow and RIP were made during quiet (QS) and active sleep (AS) in 12 infants. The first 5 min in a sleep state were used to calculate calibration factors, which were applied to subsequent validation data. The absolute percentage error between RIP and PNT tidal volumes was calculated. The percentage error was similar over a wide range of K during QS. However, K became more critical when breathing was out of phase. A standard for K of 0.5 was chosen. There was good agreement between calibration methods during QS and AS. In the first minute following calibration during QS, the mean absolute errors were 3.5, 4.1 and 5.3% for MLR, QDC and fixed K respectively. The equivalent errors in AS were 11.5, 13.1 and 13.7% respectively. The simple fixed ratio method can be used to measure tidal volume with similar accuracy to multiple linear regression and qualitative diagnostic calibration in healthy unsedated sleeping infants, although it remains to be validated in other groups of infants, such as those with respiratory disease.
ABC of 1 to 7. Services for children: the community.
Authors: J Wilson, H B Valman
Journal: BMJ (1982)

THE COMMUNITY ,~~~~~IThe fieldworkers of the district child health services are based in local clinics.The emphasis of their work is preventive and concerns identifying and treating abnormal developmental patterns in the home, clinic, school, Therapy or nursery.The services may be divided into two groups: those provided for all children, comprising mainly screening, immunisation, and health education; and those specific services provided for children with special problems. Child developmentWhen they are born, children in Harrow district are entered into the child health computer, which automatically sends appointments for immunisations.Developmental checks are performed at 6 weeks, 8 months, 18 months, 3 years, and 4 years (if necessary).A child whose growth and / r / development are normal at 6 weeks and 8 months should not be assessed o again until 18 months.The computer programme can also be adapted to include invitations for developmental checks as well as immunisations, / and GPs who do their own developmental clinics could also use the computer to issue their own appointments.At 18 months particular attention is paid to the child's motor agility and comprehension of language.At the next review, at 36 months, most children will co-operate with the Sheridan-Gardiner vision test and the Reed hearing test.Their expressive language and general abilities may also be assessed.They are seen again at 4 years only if a doctor, nurse, teacher, or parent considers there is cause for concern.With the agreement of local general practitioners in Harrow some simple medicaments (such as emulsifying ointment, dicyclomine hydrochloride, silicone cream, and treatment for head lice) are available in clinics.The clinics are run by clinical medical officers and health visitors, often helped by a trained nursing auxiliary or volunteer, who performs simple tasks such as weighing babies.Immumnsations 3 months Dphtheria-tetanus -pertussis.oral poliovaccire 5 months.Dphthera tetanu ertussis orol pace A separate immunisation clinic, with a specially trained nurse, runs 9 monohs Diphtheri-tetanus-pertusssis var polaovaccine simultaneously with a child development clinic.This ensures more effective 18 months Measles use of professional time.Triple and polio immunisation is given at 3 4 years Diphtheria -tetanus oral poliovaccne months, 5 months, and 9 months; measles immunisation at 18 months, 11 years Rubelloa after the developmental check; and the "preschool booster" (diphtheria, 13 years BCG tetanus, and polio immunisation) at 4 years.15 years ....
A molecular and evolutionary study of the beta-globin gene family of the Australian marsupial Sminthopsis crassicaudata
Authors: S. J. Cooper, R. Murphy, G. Dolman, D. Hussey, R. M. Hope
Journal: Molecular Biology and Evolution (1996)

Beta-globin gene families in eutherians (placental mammals) consist of a set of four or more developmentally regulated genes which are closely linked and, in general, arranged in the order 5'-embryonic/fetal genes-adult genes-3'. This cluster of genes is proposed to have arisen by tandem duplication of ancestral beta-globin genes, with the first duplication occurring 200 to 155 MYBP just prior to a period in mammalian evolution when eutherians and marsupials diverged from a common ancestor. In this paper we trace the evolutionary history of the beta-globin gene family back to the origins of these mammals by molecular characterization of the beta-globin gene family of the Australian marsupial Sminthopsis crassicaudata. Using Southern and restriction analysis of total genomic DNA and bacteriophage clones of beta-like globin genes, we provide evidence that just two functional beta-like globin genes exist in this marsupial, including one embryonic-expressed gene (S.c-epsilon) and one adult-expressed gene (S.c-beta), linked in the order 5'-epsilon-beta-3'. The entire DNA sequence of the adult beta-globin gene is reported and shown to be orthologous to the adult beta-globin genes of the North American marsupial Didelphis virginiana and eutherian mammals. These results, together with results from a phylogenetic analysis of mammalian beta-like globin genes, confirm the hypothesis that a two-gene cluster, containing an embryonic- and an adult-expressed beta-like globin gene, existed in the most recent common ancester of marsupials and eutherians. Northern analysis of total RNA isolated from embryos and neonatals indicates that a switch from embryonic to adult gene expression occurs at the time of birth, coinciding with the transfer of the marsupial from a uterus to a pouch environment.
TRANSMURAL MYOCARDIAL STRAIN PROFILE IS A USEFUL METHOD TO ESTIMATE THE REGIONAL MYOCARDIAL STUNNNING COURSE AMONG PATIENTS WITH A REPERFUSED ST ELEVATION ACUTE MYOCARDIAL INFARCTION : A COMPARISON WITH TC-99M SESTAMIBI SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
Authors: Noriaki Iwahashi, Masami Kosuge, Jun Okuda, Kengo Tsukahara, Yoshio Tahara, Kiyoshi Hibi, Toshiaki Ebina, Shinichi Sumita, Kazuaki Uchino, Toshiyuki Ishikawa, Satoshi Umemura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2010)
Garcia da Orta
Authors: Louis Pelner
Journal: JAMA (1966)

Just three years ago, Portugal honored one of her most famous sons, Garcia da Orta, by issuing a series of postage stamps in his honor<sup>1</sup>(Fig 1). The occasion was 400 years after the publication of his remarkable work which catalogued, discussed, evaluated, and detailed the method of cultivation of many tropical plants that were then not known to Europeans. He first described Asiatic cholera and its manifestations and also performed the first autopsy on an Indian subject with this disease. He has been called the Father of Pharmacognosy.<sup>2</sup>He was one of the founders of the great city of Bombay, India. In Bombay, he had one of the most remarkable botanical gardens in the subcontinent, where he grew many exotic tropical medicinal plants and spices. However, in recent correspondence with the Indian Tourist Bureau regarding da Orta, nothing is mentioned about his connection with the founding of
Syphilis: using modern approaches to understand an old disease
Authors: Emily L. Ho, Sheila A. Lukehart
Journal: Journal of Clinical Investigation (2011)

Syphilis is a fascinating and perplexing infection, with protean clinical manifestations and both diagnostic and management ambiguities. Treponema pallidum subsp. pallidum, the agent of syphilis, is challenging to study in part because it cannot be cultured or genetically manipulated. Here, we review recent progress in the application of modern molecular techniques to understanding the biological basis of this multistage disease and to the development of new tools for diagnosis, for predicting efficacy of treatment with alternative antibiotics, and for studying the transmission of infection through population networks.
Sputum matrix metalloproteinase-9: Tissue inhibitor of metalloproteinase-1 ratio in acute asthma
Authors: Hiroshi Tanaka, Naomitsu Miyazaki, Kensuke Oashi, Shintaro Tanaka, Mitsuhide Ohmichi, Shosaku Abe
Journal: Journal of Allergy and Clinical Immunology (2000)
Psychotherapy Research: Inertia, Recruitment, and National Policy
Authors: CLYDE H. WARD, JOHN C. RICHARDS
Journal: American Journal of Psychiatry (1968)

The much-attested reluctance of clinicians to join in psychotherapy research was tested by presenting a clinically optimal proposal to 100 of the best qualified therapists in Philadelphia. Extensive interview follow-ups demonstrated a resistance so intense that probably no more than 25 percent of the clinicians could ever be recruited. Collaborative multi-group effort is seen as the best solution to this "inertia" problem.
Defamation bill gives defence of qualified privilege to peer reviewed journal articles
Authors: C. Dyer
Journal: BMJ (2013)

A bill to reform libel law in England and Wales and make it harder to stifle scientific debate is expected to become law later this year, after it was saved by a last minute cross party consensus.

The Defamation Bill creates a statutory defence of public interest and gives a defence of qualified privilege to peer reviewed journal articles and reports of scientific conferences.

The bill’s survival was threatened when a House of Lords amendment requiring companies to prove that the allegedly defamatory statement caused or was likely to cause them substantial financial loss before they could launch a libel action was voted down in the House of Commons …
Towards a coherent terminology of gout.
Authors: P A Simkin
Journal: Annals of the Rheumatic Diseases (1993)

Proposal 1The species of crystals that precipitate in articular tissues should be referred to by single, simple terms: urate, pyrophosphate, apatite, etc.For the most part these are the names of the principal anion.Additional terms that reflect hydration states and stoichiometry- that is, dihydrate, are appropriate and
251 Phase I study of anti-IgE recombinant humanized monoclonal antibody rhuMAB-E25 (E25) in adults with moderate to severe asthma
Authors: J CORREN, J FROEHLICH, M SCHOENHOFF, S SPECTOR, G RACHELEFSKY, H SCHANKER, M PATNAIK, S SIEGEL
Journal: Journal of Allergy and Clinical Immunology (1996)
Tc-99m MIBI/Tc-99m MDP Mismatch: A Useful Scintigraphic Finding in Differentiating Myositis Ossificans From Malignant Tumor of Soft Tissue
Authors: Jabour Khoury, Jacqueline Jerushalmi, Norman Loberant
Journal: Clinical Nuclear Medicine (2006)

Myositis ossificans is a rare condition characterized by the abnormal formation of bone in the soft tissue. It has been classified in 2 forms whether it follows trauma or not. The condition is usually confused with infection or malignancy of soft tissue according to the clinical setting. Radiography is the preferred method of initial imaging, but it may not detect the lesion in the first 1 to 2 weeks. Bone scintigraphy is the method of choice for early detection of the disease and for assessing the maturity of the lesion. We present the case of a 12-year-old boy with myositis ossificans of the thigh muscles demonstrated on bone scintigraphy, which was differentiated from malignancy on Tc-MIBI scintigraphy and hence, ulterior invasive investigation was avoided.
Trisomy 4, a new chromosomal abnormality in Waldenström's macroglobulinemia: a study of 39 cases
Authors: C Terré, F Nguyen-Khac, C Barin, M J Mozziconacci, V Eclache, C Léonard, E Chapiro, H Farhat, A Bouyon, P Rousselot, S Choquet, M Spentchian, P Dubreuil, V Leblond, S Castaigne
Journal: Leukemia (2006)
Occupational cancer research in the Nordic countries.
Authors: K Kjaerheim
Journal: Environmental Health Perspectives (1999)

Occupational cancer research in the Nordic countries benefits from certain structural advantages, including the existence of computerized population registries, national cancer registries with high-quality data on cancer incidence, and a personal identification number for each inhabitant. This article outlines the utilization of this research infrastructure in Denmark, Finland, Iceland, Norway, and Sweden, together with research examples from the different countries. Future research on occupational cancer in this region requires that national legislation on electronic handling of sensitive personal information should not be stricter than the European Union Directive on individual protection with regard to personal data. A personal identification number is essential both for keeping up the high quality of data of the registers and for the high quality of the process of linking the different data sources together. Although previous occupational research has focused on male workers, a broader approach is needed in the future, including a study of how cancer risk in women may be affected by occupational activity and the question of possible cancer risk in offspring of men and women exposed to workplace carcinogens.
Antiproteinase chemotherapy of acute experimental pancreatitis using the low molecular weight oligopeptide aldehyde leupeptin.
Authors: P A Jones, J Hermon-Taylor, D A Grant
Journal: Gut (1982)

Continuous intravenous infusion of the low molecular weight trypsin inhibitor leupeptin prolonged the survival of rats with acute haemorrhagic pancreatitis (p less than 0.001) compared with controls receiving saline alone. Rats receiving high dose intravenous Trasylol (aprotinin) survived no longer than saline-only controls. Combination therapy of leupeptin with Trasylol conferred no additional benefit over animals treated with leupeptin alone. The nature of the infusion was selected blind after the induction of pancreatitis and survival was quantified by recording of body temperature. These preliminary results suggest that sterically favourable molecules which can complete the inhibiton of alpha 2-macroglobulin bound proteinases should contribute to the effective specific chemotherapy of the disease.
Damage Control
Authors: Jeremy W. Cannon
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
A New Property of an Old Remedy: Fibrinolysis and Aspirin
Authors: Oscar D. Ratnoff
Journal: New England Journal of Medicine (1977)

The dissolution of clotted blood has captivated investigators since the phenomenon was recognized at the end of the last century. The currently conventional view ascribes fibrinolysis to the action of a protease, plasmin, that normally exists in plasma in the form of an inert precursor, plasminogen. Elsewhere, Moroz1 has challenged this dogma, and suggested that fibrinolysis may also be brought about by a protease other than plasmin, an effect that he now finds is enhanced in vivo and in vitro by salicylates.In the test tube, plasminogen can be transformed to plasmin in many ways. For example, incubation of plasma . . .
Intrathyroidal Parathyroid Adenoma Or Hyperplasia
Authors: Allen M. Spiegel
Journal: JAMA (1975)

In six surgically proved intrathyroidal parathyroid tumors, neither thyroid scan nor gross appearance of the thyroid at surgery allowed reliable detection of parathyroid glands wholly within the thyroid. Preoperative selective catheterization of thyroid veins with radioimmunoassay for parathyroid hormone facilitated successful removal of hyperfunctioning intrathyroidal parathyroid tissue in all five cases in which it was performed.
Moonlighting: Making a Buck, Compassion, and Quality Control
Authors: Ralph B. Piening
Journal: JAMA (1990)

<h3>To the Editor.—</h3> I simply must respond to the letter about moonlighting by Dr Cohen.<sup>1</sup>He and his ever-compassionate faculty seem to have calculated a method to make money off the moonlighting activity of the house staff. Apparently, the "faculty supervisor" is available by beeper or telephone while the house officer stays up all night and does the work. The faculty physician is then paid a commensurate amount for sitting at home and "being available." We are constantly hearing pleas for better physician role models for residents and medical students. Is it any wonder that house staff are so cynical when they are so blatantly ripped-off, as in the above scenario? These house officers have a permanent license and in the eyes of the state are permitted to practice medicine on their own. Assuming job performance is not compromised, it is none of the university's business how a resident
Medical Ramifications of the Federal Regulation of the Social Security Disability Insurance Program
Authors: NORTIN M. HADLER
Journal: Annals of Internal Medicine (1982)

Social Security Disability Insurance is a federally created and regulated insurance plan. The definition of disability as it relates to work capacity is exclusively the purview of government administrators. The primary physician's opinion has little, it any, impact on decision. Administering this insurance scheme requires the quantification of illness as it relates to work capacity (disability). What has evolved is a program that insures for the amount of "disease." The assumption is that with more disease, there is a greater likelihood of illness, even illness manifest as work incapacity. Leaving this underlying assumption tacit is responsible for the adversary climate that envelops the physician, the patient-claimant, and the administrators. It is also responsible for the paucity of clinical investigations into the critical issue of the amount and form of illness a diseased person will have.
Diagnosis of Pathologically Early HCC with EOB-MRI: Experiences and Current Consensus
Authors: Tomoaki Ichikawa, Katsuhiro Sano, Hiroyuki Morisaka
Journal: Liver Cancer (2014)

&lt;b&gt;&lt;i&gt;Objective: &lt;/i&gt;&lt;/b&gt;After much debate, the International Consensus Group for Hepatocellular Neoplasia (ICGHN) has recently arrived at a conclusion regarding the pathological criteria for early hepatocellular carcinoma (HCC). They have stated that stromal invasion should be recognized as the most important pathological finding for precisely diagnosing and differentiating early HCC from dysplastic nodules (DN). &lt;b&gt;&lt;i&gt;Methods: &lt;/i&gt;&lt;/b&gt;We conducted a review of the imaging findings from multi-imaging modalities of early HCC cases diagnosed according to the pathological criteria of the ICGHN. The multi-imaging modalities included gadoxetic acid (Gd-EOB-DTPA) enhanced magnetic resonance imaging (MRI), abbreviated as EOB-MRI, contrast-enhanced CT (CE-CT), CT during arterioportography (CTAP), and CT during hepatic arteriography (CTHA). It has been shown that EOB-MRI is the only imaging modality that has sufficient resolution for the detection and classification of early HCC. &lt;b&gt;&lt;i&gt;Results: &lt;/i&gt;&lt;/b&gt;The most significant imaging feature for diagnosing early HCC was hypointensity on hepatobiliary-phase (HP) images of EOB-MRI; all of the cases of early HCC that were detected on HP images of EOB-MRI showed hypointensity, while all of the images of DN showed isointensity or hyperintensity compared with the liver parenchyma. The results of the diagnostic performance analysis showed that EOB-MRI had excellent sensitivity (97%) for detecting early HCC and outstanding specificity (100%) for distinguishing early HCC from DN. &lt;b&gt;&lt;i&gt;Conclusions: &lt;/i&gt;&lt;/b&gt;Considering the results from imaging-pathologic correlations and follow-up studies indicating that many early-stage hepatocellular nodules showing hypointensity on HP images of EOB-MRI tend to develop hypervascularization during a relatively short follow-up period, it is beginning to be accepted that such nodules may be treated as early HCC. However, hepatologists and radiologists should also recognize that some cases of early HCC may show isointensity or hyperintensity on HP images of EOB-MRI, making it impossible to differentiate early HCC from DN, although the low prevalence of such nodules may be unlikely to affect the generally accepted follow-up protocols for cirrhotic patients. Our results and other recent reports have indicated that signal-intensity patterns on HP images of EOB-MRI for DN and early HCC directly correlate with the degree of expression of the organic anion transporting polypeptide (OATP) 1B3 in the nodules. Thus, the diagnostic performance of pathological analyses for early HCC cases may be dramatically improved, nearly up to that of EOB-MRI, by incorporating an OATP1B3 staining method.
OUTCOMES FOLLOWING PROLONGED EXTRA CORPOREAL MEMBRANE OXYGENATION SUPPORT IN CHILDREN WITH CARDIAC DISEASE: EXTRACORPOREAL LIFE SUPPORT ORGANIZATION REGISTRY STUDY
Authors: Laura Schoeneberg, Dean Merrill, Pratik Sandesara, Barbara Haney, Erica Molitor-Kirsch, James O'Brien Jr, Hongying Dai, Geetha Raghuveer
Journal: Journal of the American College of Cardiology (2013)