tbuckley/cabot-search huggingface dataset:
Myocardial Infarction and Estrogen Therapy in Post-Menopausal Women
Authors: Lynn Rosenberg, Bruce Armstrong, Hershel Jick
Journal: New England Journal of Medicine (1976)

Data obtained from two multipurpose surveys of hospitalized patients were examined to determine the risk of nonfatal acute myocardial infarction in post-menopausal women 40 to 75 years of age in relation to use of estrogen-containing drugs. Eight (2.4 per cent) of 336 myocardial infarction patients and 330 (4.9 per cent) of 6730 reference patients were regular estrogen users (crude rate ratio, 0.47) at the time of hospitalizaron. After control for confounding variables — among them, age, past history of myocardial infarction, angina, diabetes, and hypertension (alone or in combination) and cigarette smoking — the summary point estimate of rate ratio was 0.97 with 95 per cent confidence limits of 0.48 and 1.95. Thus, there was no evidence of a statistically significant association between current regular use of estrogens and nonfatal acute myocardial infarction. (N Engl J Med 294:1256–1259, 1976)
African states call for ban on tobacco advertising
Authors: P. Brown
Journal: BMJ (2001)

African and Asian states have attacked the current draft of the international tobacco treaty for being too weak and last week tabled new tougher proposals for the next round of negotiations in November. The strength of the developing countries' positions—which contrasted sharply with those of the industrialised countries—has surprised some anti-tobacco campaigners.

Even Zimbabwe and Malawi, which rank sixth and …
The Combined Use of CPIB and Thyroxine in Treatment of Hyperlipoproteinemias
Authors: EDWARD H. STRISOWER
Journal: Circulation (1966)

The combined effect of CPIB and levothyroxine on lipoprotein concentrations in 13 patients with various types of hyperlipoproteinemias has been investigated. Analysis of long-term observations indicates the following: (1) CPIB lowers Sf 20-10 5 concentrations profoundly regardless of the initial lipoprotein distribution. (2) Addition of levothyroxine to CPIB produces no further significant effect on Sf 20-10 5 concentrations. (3) The effect of CPIB on Sf 0-20 concentrations appears to depend on the initial lipoprotein distribution. In carbohydrate-sensitive hyperlipemias CPIB can markedly increase Sf 0-20 levels, whereas it has no such effect in other hyperlipoproteinemias. On occasion, a marked Sf 0-20 lowering effect occurs in patients with Sf 0-20 hyperlipoproteinemias. Two such instances are reported in detail. (4) In combined Sf 0-20 and Sf 20-10 5 hyperlipoproteinemias the combination of CPIB and thyroxine is often more effective than either agent used separately in reducing total lipoprotein concentrations.
TRANSESOPHAGEAL ECHOCARDIOGRAPHY AND DC CARDIOVERSION: 10 YEARS EXPERIENCE IN OVER 2700 PATIENTS
Authors: Tristan B. Klosterman, Hirad Yarmohammadi, Kevin Shrestha, Brandon Varr, Bruce Lindsey, Andrew Zurich, Wai Hong W. Tang, Allan L. Klein
Journal: Journal of the American College of Cardiology (2010)
Sexual Dysfunction Secondary to Topical Ophthalmic Timolol
Authors: F. T. Fraunfelder, S. Martha Meyer
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The 34th most common prescription drug in the United States in 1983 was timolol maleate eyedrops (Timoptic). Although unusual and less known systemic side effects are often not recognized as being associated with a patient's eyedrops, the National Registry of Drug-Induced Ocular Side Effects, at Oregon Health Sciences University, Portland, has received over 1,700 case reports of adverse reactions secondary to topical ophthalmic timolol, and 63% of these reports concern systemic effects. Systemic β-blockade has been demonstrated secondary to both systemic and topical ophthalmic administration of β-adrenergic blockers. Sexual dysfunction has been reported in patients using oral β-blockers for angina pectoris or hypertension.<sup>1-3</sup>In addition, the registry has compiled 28 complaints of various sexual dysfunctions noted in 25 patients following usual doses of topical ocular timolol. Impotence was reported by 18 patients, decreased libido in nine patients, and decreased ejaculate volume in one patient. Five of
Psychiatrist is suspended for a year for abusing position at GMC
Authors: C. Dyer
Journal: BMJ (2011)

A consultant psychiatrist has been suspended from practice for a year for abusing his position as a medical examiner and supervisor for the UK General Medical Council to try to get special treatment for a colleague who was caught drink driving.

Kenneth Checinski, a senior lecturer in the psychiatry of addictive behaviour at St George’s, University of London, concealed his “close personal relationship” with the fellow consultant when he asked the GMC to lift restrictions …
ON THE GREATER SUSCEPTIBILITY OF AN ALIEN VARIETY OF HOST TO AN AVIAN TUMOR
Authors: Peyton Rous, Linda B. Lange
Journal: The Journal of Experimental Medicine (1914)

A transplantable sarcoma of the fowl, known as Chicken Tumor XVIII, in our series, succeeds better in chickens of an alien breed (Plymouth Rock) than in those of the variety in which it originated (brown Leghorn). This is not due to gross physical differences in the two breeds but to some more subtle factor and one which perhaps acts by influencing the agent causing the tumor. It would seem that Chicken Tumor XVIII, as it occurred in nature, was an instance of a disease appearing spontaneously in an animal of relatively insusceptible variety.
Delayed Recall of Active Tetanus Immunization
Authors: George C. Kaiser
Journal: JAMA (1961)

SINCE ITS INCEPTION in 1925, active immunization against tetanus has been employed extensively in both military and civilian populations with good results. It is agreed that active immunization is superior to passive. There is, however, one aspect of active immunization that remains unknown, namely after how long an interval, since the latest toxoid administration, an adequate response to a booster injection may be obtained. Much work has been done in the field of tetanus immunity, but it has been concerned chiefly with the period immediately following active immunization, and the effect of booster injections within 11 years of the latest administration of tetanus toxoid. In order to explore the possibility of extending the benefits of active tetanus immunity, a group of individuals in which the interval was 14 to 18 years was studied. <h3>Material and Method</h3> Forty-one male veterans of World War II, who were admitted to the surgical service
Influence of Patient Literacy on the Effectiveness of a Primary Care–Based Diabetes Disease Management Program
Authors: Russell L. Rothman
Journal: JAMA (2004)

ContextLow literacy is an important barrier for patients with diabetes, but interventions to address low literacy have not been well examined.ObjectiveTo examine the role of literacy on the effectiveness of a comprehensive disease management program for patients with diabetes.Design, Setting, and ParticipantsAnalysis of the influence of literacy on glycemic control and systolic blood pressure using data from a randomized controlled trial (conducted from February 2001 through April 2003) of a comprehensive diabetes management program. Participants were 217 patients aged 18 years or older with type 2 diabetes and poor glycemic control (glycosylated hemoglobin [HbA1c] levels ≥8.0%) and presenting to a US academic general internal medicine practice.InterventionsAll communication to patients was individualized and delivered to enhance comprehension among patients with low literacy. Intervention patients received intensive disease management from a multidisciplinary team. Control patients received an initial management session and continued with usual care.Main Outcome MeasuresAchievement of goal HbA1c levels and systolic blood pressure at 12-month follow-up for control and intervention patients stratified by literacy status.ResultsComplete 12-month data were available for 193 patients (89%). Among patients with low literacy, intervention patients were more likely than control patients to achieve goal HbA1c levels (≤7.0%) (42% vs 15%, respectively; adjusted odds ratio [OR], 4.6; 95% confidence interval [CI], 1.3 to 17.2; P = .02). Patients with higher literacy had similar odds of achieving goal HbA1c levels regardless of intervention status (24% vs 23%; adjusted OR, 1.0; 95% CI, 0.4 to 2.5; P = .98). Improvements in systolic blood pressure were similar by literacy status.ConclusionsLiteracy may be an important factor for predicting who will benefit from an intervention for diabetes management. A diabetes disease management program that addresses literacy may be particularly beneficial for patients with low literacy, and increasing access to such a program could help reduce health disparities.
A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RARα transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study
Authors: Norio Asou, Yuji Kishimoto, Hitoshi Kiyoi, Masaya Okada, Yasukazu Kawai, Motohiro Tsuzuki, Kentaro Horikawa, Mitsuhiro Matsuda, Katsuji Shinagawa, Tohru Kobayashi, Shigeki Ohtake, Miki Nishimura, Masatomo Takahashi, Fumiharu Yagasaki, Akihiro Takeshita, Yukihiko Kimura, Masako Iwanaga, Tomoki Naoe, Ryuzo Ohno
Journal: Blood (2007)
Charlotte Paterson and colleagues respond to Margaret McCartney
Authors: C. Paterson, N. Britten, S. Rugg, R. S. Taylor, P. Griffiths, J. Bridges, B. McCallum, G. Kite
Journal: BMJ (2011)

The CACTUS Study is a randomised pragmatic trial with a nested qualitative study comparing traditional acupuncture with usual care in people who consult frequently with medically unexplained symptoms.1 2 Margaret McCartney has based her Observations article about it on several inaccuracies (quotations from her article in italics below).3

(1) The “wellbeing score” was better in the control group than in the acupuncture group . This statement is untrue: an adjusted mean difference in favour of acupuncture was seen with wellbeing (wellbeing questionnaire, W-BQ12: 4.4 (1.6 to 7.2); P=0.002). This difference remained significant after missing values were imputed (3.4 (0.5 to 6.3); P=0.02).

(2) The graphical …
On Awakening Paralyzed During Surgery
Authors: Rosamond Michael
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I have read Dr Blacher's article with great interest. I experienced this phenomenon, I am convinced, last January when I underwent six hours of vascular surgery (endarterectomy of ilia and aorta, repair of renal arterial autograft, and lumbar sympathectomy). I spoke of it only to my surgeon and to my mother. I have had none of the typical night-mares experienced by the individuals quoted in the article, but I have often wondered about it, since I had no idea how long it lasted, what caused it, what it really was. I theorized that it may have happened in the recovery room and that the nurse in charge had not realized that I was awake and so had not started the morphine dripping into my arm. Browsing through<i>JAMA</i>this afternoon, I saw the title of this article and read it carefully. It seemed to me that it
Frank Haddow Scadding
Authors: Patricia Chapman, Gabriel Laszlo, Angus Robson
Journal: BMJ (2007)

Frank grew up in Lincolnshire and was educated at De Aston School, Market Rasen, and the Middlesex Hospital Medical School. After five years' wartime service partly in the Gambia he left the Royal Army Medical Corps in1946 as lieutenant colonel; he was later appointed honorary consultant to the army. The majority of his clinical training was undertaken at the Middlesex …
Skin cancer risk in <i>BRCA1/2</i> mutation carriers
Authors: P.V. Gumaste, L.A. Penn, R.M. Cymerman, T. Kirchhoff, D. Polsky, B. McLellan
Journal: British Journal of Dermatology (2014)

Women with BRCA1/2 mutations have an elevated risk of breast and ovarian cancer. These patients and their clinicians are often concerned about their risk for other cancers, including skin cancer. Research evaluating the association between BRCA1/2 mutations and skin cancer is limited and has produced inconsistent results. Herein, we review the current literature on the risk of melanoma and nonmelanoma skin cancers in BRCA1/2 mutation carriers. No studies have shown a statistically significant risk of melanoma in BRCA1 families. BRCA2 mutations have been linked to melanoma in large breast and ovarian cancer families, though a statistically significant elevated risk was reported in only one study. Five additional studies have shown some association between BRCA2 mutations and melanoma, while four studies did not find any association. With respect to nonmelanoma skin cancers, studies have produced conflicting results. Given the current state of medical knowledge, there is insufficient evidence to warrant increased skin cancer surveillance of patients with a confirmed BRCA1/2 mutation or a family history of a BRCA1/2 mutation, in the absence of standard risk factors. Nonetheless, suspected BRCA1/2 mutation carriers should be counselled about skin cancer risks and may benefit from yearly full skin examinations.
Frequency of implantable cardioverter fibrillator discharges in New York following the world trade center attack
Authors: Aysha Arshad, Marcin Kowalski, Atul Kukar, Valentin Suma, Margot E. Vloka, Frederick A. Ehlert, Bengt Herweg, Jacqueline E. Donnelly, Julie Philip, George Reed, Alan Rozanski, Jonathan S. Steinberg
Journal: Journal of the American College of Cardiology (2003)
Scleromyxoedema—successful treatment with plasma exchange and immunosuppression
Authors: A.W. MACFARLANE, A. DAVENPORT, J.L. VERBOV, H.J. GOLDSMITH
Journal: British Journal of Dermatology (1987)

Journal Article Scleromyxoedema—successful treatment with plasma exchange and immunosuppression Get access A.W. MACFARLANE, A.W. MACFARLANE Department of Dermatology, Royal Liverpool Hospital, Prescol Street, Liverpool, L7 8XP, U.K. Dr A.W.Macfarlane. Search for other works by this author on: Oxford Academic Google Scholar A. DAVENPORT, A. DAVENPORT Department of Renal Unit, Royal Liverpool Hospital, Prescot Street, Liverpool, L7 8XP, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.L. VERBOV, J.L. VERBOV Department of Dermatology, Royal Liverpool Hospital, Prescol Street, Liverpool, L7 8XP, U.K. Search for other works by this author on: Oxford Academic Google Scholar H.J. GOLDSMITH H.J. GOLDSMITH Department of Renal Unit, Royal Liverpool Hospital, Prescot Street, Liverpool, L7 8XP, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue 5, 1 November 1987, Pages 653–657, https://doi.org/10.1111/j.1365-2133.1987.tb07499.x Published: 01 November 1987
The Bone Scan Flare Phenomenon in Non–Small-Cell Lung Cancer
Authors: JULIE LEMIEUX, JEAN GUIMOND, FRANCIS LABERGE, CAROLE ST-PIERRE, YVON CORMIER
Journal: Clinical Nuclear Medicine (2002)

Purpose The bone scan flare phenomenon, defined as an increase in the number or intensity of bone lesions with subsequent improvement while the patient is receiving chemotherapy, has been described in solid tumors including breast cancers and small-cell lung cancers. The purpose of this study was to verify the existence of the bone scintigraphic flare phenomenon in patients with non–small-cell lung cancer (NSCLC) during chemotherapy and thus determine the utility of bone scintigraphy in the follow-up of these patients. Materials and Methods Thirty-three patients with NSCLC with bone metastases and who had been treated with chemotherapy were included in the study. The outcome of bone scintigraphy was compared with that in other neoplastic sites. Results The flare phenomenon was considered likely in 8 of the 33 patients. It was confirmed in two patients, invalidated in four, and remained doubtful in two. Conclusions The bone flare phenomenon occurs in NSCLC. It renders bone scintigraphy less useful in the evaluation of tumoral response in the patients in whom it is considered likely.
Pulmonary arterial pressure and structure in the patas monkey (Erythrocebus patas patas)
Authors: D. Heath, E. L. Jones, E. Housley
Journal: Cardiovascular Research (1970)

Journal Article Pulmonary arterial pressure and structure in the patas monkey (Erythrocebus patas patas) Get access D. Heath, D. Heath From the Departments of Pathology, Universities of Liverpool and Birmingham Search for other works by this author on: Oxford Academic PubMed Google Scholar E. L. Jones, E. L. Jones From the Departments of Pathology, Universities of Liverpool and Birmingham Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Housley E. Housley From the Departments of Pathology, Universities of Liverpool and Birmingham Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 4, Issue 4, October 1970, Pages 515–519, https://doi.org/10.1093/cvr/4.4.515 Published: 01 October 1970 Article history Accepted: 19 March 1970 Published: 01 October 1970
Hemophiliac patient's knowledge and educational needs concerning acquired immunodeficiency syndrome
Authors: Martha A. Hargraves, Janine M. Jason, Terence L. Chorba, Robert C. Holman, Gloria R. Dixon, Christine J. Eastham, Alan P. Brownstein, Peggy Heine, David P. Agle
Journal: American Journal of Hematology (1987)

The Patient Knowledge Assessment Study (PKAS) was conducted among 107 male hemophilic patients, aged 15 to 67 years, at 19 hemophilia treatment centers (HTC). Participants were given a 30-item questionnaire concerning the cause of acquired immunodeficiency syndrome (AIDS), the groups at risk, and modes of transmission. The questionnaire included questions on the participant's status in regard to antibody to human T-lymphotropic retrovirus, type III/lymphadenopathy-associated virus (HTLV-III/LAV), and the meaning of this test result. HTC health-care providers were asked to complete a separate questionnaire containing 17 questions about information given patients concerning their HTLV-III/LAV antibody status and its meaning. Overall, patients had a good base of knowledge about AIDS; however, there were gaps in this knowledge. Twenty-nine percent of patients did not know that spouses of AIDS patients were at risk for AIDS; 47% did not know that sexual partners of persons with hemophilia were at risk; and 32% did not know that hemophilic children were at risk. Further, only 69% understood that antibody-positive individuals had had contact with the AIDS virus. Identifying these and other areas of misunderstanding will provide the information needed to design educational strategies and psychosocial support programs appropriate for the hemophilic population, and which may serve as a model for other populations.
Abstract 1842: Identifying long noncoding RNAs in breast cancer microarrays.
Authors: Hui Jia, Leonard Lipovich, Donghong Ju, Mary A. Kosir
Journal: Cancer Research (2013)

Abstract Long noncoding RNAs (lncRNA) are powerful regulators of gene expression. The emerging role of long noncoding RNAs (lncRNA) is facilitated by the development of new technologies such as tilling array and next generation sequencing. In this study, our research focused on lncRNA's regulatory mechanisms in breast cancer. Methods: The Gencode v7 lncRNA and FANTOM5 lncRNA datasets were integrated as our lncRNA transcriptome. The expression profile was from four publications of microarray analysis in breast cancer. First, we checked the Affymetrix probe dataset U133 plus with our lncRNA transcriptome. If a probe was on the same strand and 100% fell into the exonic region of one lncRNA transcript, then the probe could this lncRNA. We integrated all lncRNAs from our transcriptome which matched the probes from the supplementary data of four papers and selected those occurred more than once. Results: There were 23 nonredundant lncRNA candidates identified. Among those 23 candidates, PTENP1 was identified. PTENP1 is the pseudogene of tumor suppressor gene PTEN. The 3’UTR can bind the same miRNAs as the related protein-coding gene, PTEN. This suggests that pseudogenes may have a biological function as ‘decoys’, sequestering miRNAs and thereby affecting their regulation of expressed genes. Another candidate identified was ENST00000415285.1, which is the antisense gene of FGF14. FGF14 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including tumor growth and invasion. ENST00000415285.1 is up-regulated in breast cancer, while the expression level of FGF14 is unknown, so further research is necessary to predict the possible mechanism of regulation to FGF14. Conclusion: LncRNAs are identified in datasets for breast cancer that may elucidate further regulatory mechanisms driving the pathogenesis of breast cancer. Citation Format: Hui Jia, Leonard Lipovich, Donghong Ju, Mary A. Kosir. Identifying long noncoding RNAs in breast cancer microarrays. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1842. doi:10.1158/1538-7445.AM2013-1842
Beyond fibrogenesis: Stellate cells take center stage as immune-response modulators
Authors: Anand N. Bhatt, David H. Adams, Kris Kowdley, Geoffrey McCaughan, Christian Trautwein
Journal: Hepatology (2009)

The liver has been generally considered an organ prone to tolerance induction and maintenance. However, whether and how the unique liver microenvironment contributes to tolerance maintenance is largely unknown. Here, we used liver fibroblastic stromal cells to mimic the liver microenvironment and found that liver stroma could induce Lin(-)CD117(+) progenitors to differentiate into dendritic cells (DCs) with low CD11c, MHC II but high CD11b expression, high IL-10, but low IL-12 secretion. Such regulatory DCs could inhibit T-cell proliferation in vitro and in vivo, induce apoptosis of the activated T cells, and alleviate the damage of autoimmune hepatitis. Furthermore, liver stroma-derived macrophage colony-stimulating factor (M-CSF) was found to contribute to the generation of such regulatory DCs. Regulatory DC-derived PGE2 and T cell-derived IFN-gamma were responsible for the regulatory function. The natural counterpart of regulatory DCs was phenotypically and functionally identified in the liver. Importantly, Lin(-)CD117(+) progenitors could be differentiated into regulatory DCs in the liver once transferred into the liver. Infusion with liver regulatory DCs alleviated experimental autoimmune hepatitis. Therefore, we demonstrate that the liver microenvironment is highly important to program progenitors to differentiate into regulatory DCs in situ, which contributes to the maintenance of liver tolerance.
Cystic medial necrosis in coarctation of the aorta: a potential factor contributing to adverse consequences observed after percutaneous balloon angioplasty of coarctation sites.
Authors: J M Isner, R F Donaldson, D Fulton, I Bhan, D D Payne, R J Cleveland
Journal: Circulation (1987)

Percutaneous transluminal angioplasty has been shown to be both feasible and efficacious for the treatment of aortic coarctation. Recent reports, however, have indicated that the development of aortic aneurysms at or near the coarctation segment may complicate attempts to treat this lesion by catheter-based intervention. Accordingly, we examined the light microscopic features of coarctation segments excised at surgery (n = 31) or obtained at autopsy (n = 2) in 33 patients with coarctation of the aorta. Cystic medial necrosis, defined as depletion and disarray of elastic tissue, was observed in each of the 33 specimens. In the majority of coarctation specimens (22 of 33 or 67%) the extent of cystic medial necrosis, graded semiquantitatively on a scale of 0 (normal aorta) to 3+, was severe (3+). The finding that cystic medial necrosis represents a consistent histologic feature of coarctation of the aorta provides a pathologic basis for the formation of aneurysms observed after balloon angioplasty of coarctation sites.