The Irradiated Hamster Test
Authors: J. WAYNE STREILEIN
Journal: Annals of Internal Medicine (1966)

Article1 September 1966The Irradiated Hamster TestA New Method of Donor Selection for Homotransplantation in ManJ. WAYNE STREILEIN, M.D., E. A. HILDRETH, M.D., F.A.C.P., H. RAMSEIER, D.SCI., J. KORNBLUM, M.D.J. WAYNE STREILEIN, M.D.Search for more papers by this author, E. A. HILDRETH, M.D., F.A.C.P.Search for more papers by this author, H. RAMSEIER, D.SCI.Search for more papers by this author, J. KORNBLUM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-3-511 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous report (1), it was shown that homologous rodent lymphoid cell mixtures of binary origin* evoke delayed reactions when injected intracutaneously in irradiated hamsters. The intensities of these reactions appeared to be related to the degree of immunogenetic disparity between the cell donors as revealed by the survival times of skin homografts exchanged between members of the strains concerned.These empiric observations suggested that, if mixtures of human lymphoid cells behave in a similar manner when injected intracutaneously into irradiated hamsters, their reactions might furnish the basis of a means of donor selection for homotransplantation in man. Experimental...References1. RAMSEIERSTREILEIN HJW: Homograft sensitivity reactions in irradiated hamsters. Lancet 1: 622, 1965. CrossrefMedlineGoogle Scholar2. BILLINGHAMSILVERS REWK (editors): Transplantation of Tissues and Cells. The Wistar Institute Press, Philadelphia, 1961, p. 90. Google Scholar3. HILDRETHFREDERICRANDALL EAMWP: Alterations in delayed hypersensitivity produced by live attenuated measles in man. Trans. Amer. Clin. Climat. Ass. 75: 37, 1964. MedlineGoogle Scholar4. 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Nature (London) 204: 998, 1964. CrossrefMedlineGoogle Scholar10. BRENTMEDAWAR LPB: Tissue transplantation: a new approach to the "typing" problem. Brit. Med. J. 2: 269, 1963. CrossrefMedlineGoogle Scholar11. AMOSNICKSPEACOCKESIEKER DBPJNHO: An evaluation of the normal lymphocyte transfer test in man. J. Clin. Invest. 44: 219, 1965. CrossrefMedlineGoogle Scholar12. Kidney Transplant Registry. Transplantation 3: 294, 1965. CrossrefMedlineGoogle Scholar13. SIMONSEN M: Strong transplantation antigens in man. Lancet 1: 415, 1965. CrossrefMedlineGoogle Scholar14. BRENTBROWNMEDAWAR LJBPB: in Biological Problems of Grafting, edited by ALBERT, F., MEDAWAR, P. B. Blackwell Scientific Publications, Oxford, 1959, p. 70. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Department of Medical Genetics and the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa.This work was supported in part by grant AICA-07001 and General Research Support Grant 1-GS-115, U. S. Public Health Service, Bethesda, Md., with the generous support of the Ship 'N Shore Foundation, and Public Health Service Fellowships 5-F2-HD-20, 472-02, from the Institute of Child Health and Human Development and 2-F2-AI-20, 465-02, from the Institute of Allergy and Infectious Diseases.Requests for reprints should be addressed to J. Wayne Streilein, M.D., Department of Medical Genetics, B-103, Richards Bldg., University of Pennsylvania School of Medicine, Philadelphia, Pa. 19104.*The terms binary and unitary have been adopted to describe, conveniently, injections containing lymphoid cells from: [1] two individuals, binary; or from [2] one individual, unitary. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTrans vivo analysis of human delayed-type hypersensitivity reactivityBiological Activities of Antilymphocytic SerumTransplantation AntigensLymphocytes and Transplantation ImmunityHuman Tissue Transplantation 1 September 1966Volume 65, Issue 3Page: 511-520KeywordsChild healthFellowshipsHomograftsHomotransplantationInfectious diseasesLymphocytesMedical geneticsMedical servicesResearch grantsSkin grafting Issue Published: 1 September 1966 PDF DownloadLoading ...