tbuckley/cabot-search huggingface dataset:
Transfer of influenza vaccine–primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial
Authors: Edward A. Stadtmauer, Dan T. Vogl, Eline Luning Prak, Jean Boyer, Nicole A. Aqui, Aaron P. Rapoport, Kenyetta R. McDonald, Xiaoling Hou, Heather Murphy, Rita Bhagat, Patricia A. Mangan, Anne Chew, Elizabeth A. Veloso, Bruce L. Levine, Robert H. Vonderheide, Abbas F. Jawad, Carl H. June, Kathleen E. Sullivan
Journal: Blood (2010)
Accuracy of Pelvic Examination
Authors: Ann K. Ferris, Marilyn M. Schapira, Mark J. Young
Journal: Annals of Internal Medicine (1991)

Letters15 March 1991Accuracy of Pelvic ExaminationAnn K. Ferris, MD, Marilyn M. Schapira, MD, MPH, Mark J. Young, MDAnn K. Ferris, MDSearch for more papers by this author, Marilyn M. Schapira, MD, MPHSearch for more papers by this author, Mark J. Young, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-6-522_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: There is renewed interest in critically evaluating the physical examination skills that are taught to medical students and residents (1). The bimanual pelvic examination is a method of detecting ovarian cancer (2) and other diseases. However, the sensitivity and specificity of the bimanual pelvic examination in the detection of an adnexal mass have not been well established. We report on a study that used synthetic models of the female pelvis to evaluate the ability of internal medicine residents to detect an adnexal mass by bimanual pelvic examination.The participants were 30 internal medicine residents at a university...References1. Wigton R, Blank L, Nicolas J, and Tape T. Procedural skills training in internal medicine residencies. Ann Intern Med. 1989;111:932-8. LinkGoogle Scholar2. Ranney B and Ahmad M. Early identification, differentiation, and treatment of ovarian neoplasia. Int J Gynaecol Obstet. 1979;17:209-17. CrossrefMedlineGoogle Scholar3. Hanley J and Lippman-Hand A. If nothing goes wrong, is everything all right? Interpreting zero numerators. JAMA. 1983;249:1743-5. CrossrefMedlineGoogle Scholar4. Fletcher S, O'Malley M, and Bruce L. Physicians' abilities to detect lumps in silicone breast models. JAMA. 1985;253:2224-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Ann K. Ferris, MD; Marilyn M. Schapira, MD, MPH; Mark J. Young, MDAffiliations: Medical College of Wisconsin Milwaukee, WI 53295 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeed for comprehensive women's health continuing medical education among primary care physiciansCatheterization Prior to Evacuation of Uterus and Diagnostic CurettagePelvic manikins as learning aidsScreening for ovarian cancer: The role of noninvasive imaging techniquesA national cancer institute sponsored screening trial for prostatic, lung, colorectal, and ovarian cancersInternal medicine training in ambulatory gynecology 15 March 1991Volume 114, Issue 6Page: 522-522KeywordsOvarian cancerPelvisSpecificity ePublished: 1 December 2008 Issue Published: 15 March 1991 PDF downloadLoading ...
Occupational Skin Disease
Authors: Marie-Louise Johnson
Journal: JAMA (1983)

Dr Adams has performed a remarkable service. He has put together, in encyclopedic fashion, the many environmental allergens that can disrupt the integrity of the integument through occupational exposure. Although he expects his audience to be conversant with the skin changes caused by irritation and allergic sensitization and their identification, he does lead the reader through the approach to various cutaneous changes and the more common causes of them. A course in basic dermatology is not provided, nor should it be expected. The focus is on the factors that evoke the dermatologic disease. The worth as well as the technique of diagnostic patch testing are underscored. Considerable time is given not only to the treatment and prevention of occupational skin diseases but also to the correct approach of the physician consultant who investigates the workplace in search of occupational hazards that relate to the skin.  Many in glancing through Dr
The Hot Stripe Sign
Authors: CHRISTOPHER J. PALESTRO, DEBORA S. FINEMAN, STANLEY J. GOLDSMITH
Journal: Clinical Nuclear Medicine (1990)

Causes of focally increased radiotracer activity on Tc-99m SC liver-spleen scintigraphy include vena caval obstruction, Budd-Chiari syndrome, focal nodular hyperplasia, and tricuspid insufficiency. Artifactually increased activity may result from a malpositioned central venous catheter, free pertechnetate in the stomach, or an overlying breast. An unusual variation of this last artifact, also known as the “hot stripe sign,” was encountered during routine liver-spleen imaging of a 65-year-old woman who had breast carcinoma.
Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease
Authors: Elena Aikawa, Matthias Nahrendorf, David Sosnovik, Vincent M. Lok, Farouc A. Jaffer, Masanori Aikawa, Ralph Weissleder
Journal: Circulation (2007)

Background— Visualizing early changes in valvular cell functions in vivo may predict the future risk and identify therapeutic targets for prevention of aortic valve stenosis. Methods and Results— To test the hypotheses that (1) aortic stenosis shares a similar pathogenesis to atherosclerosis and (2) molecular imaging can detect early changes in aortic valve disease, we used in vivo a panel of near-infrared fluorescence imaging agents to map endothelial cells, macrophages, proteolysis, and osteogenesis in aortic valves of hypercholesterolemic apolipoprotein E–deficient mice (30 weeks old, n=30). Apolipoprotein E–deficient mice with no probe injection (n=10) and wild-type mice (n=10) served as controls. Valves of apolipoprotein E–deficient mice contained macrophages, were thicker than wild-type mice ( P &lt;0.001), and showed early dysfunction detected by MRI in vivo. Fluorescence imaging detected uptake of macrophage-targeted magnetofluorescent nanoparticles (24 hours after injection) in apolipoprotein E–deficient valves, which was negligible in controls ( P &lt;0.01). Valvular macrophages showed proteolytic activity visualized by protease-activatable near-infrared fluorescence probes. Ex vivo magnetic resonance imaging enhanced with vascular cell adhesion molecule-1–targeted nanoparticles detected endothelial activation in valve commissures, the regions of highest mechanical stress. Osteogenic near-infrared fluorescence signals colocalized with alkaline phosphatase activity and expression of osteopontin, osteocalcin, Runx2/Cbfa1, Osterix, and Notch1 despite no evidence of calcium deposits, which suggests ongoing active processes of osteogenesis in inflamed valves. Notably, the aortic wall contained advanced calcification. Quantitative image analysis correlated near-infrared fluorescence signals with immunoreactive vascular cell adhesion molecule-1, macrophages, and cathepsin-B ( P &lt;0.001). Conclusions— Molecular imaging can detect in vivo the key cellular events in early aortic valve disease, including endothelial cell and macrophage activation, proteolytic activity, and osteogenesis.
Incidence and Prognostic Value of Early Repolarization Pattern in the 12-Lead Electrocardiogram
Authors: Daisuke Haruta, Kiyotaka Matsuo, Akira Tsuneto, Shinichiro Ichimaru, Ayumi Hida, Nobuko Sera, Misa Imaizumi, Eiji Nakashima, Koji Maemura, Masazumi Akahoshi
Journal: Circulation (2011)

Background— Early repolarization pattern is a common ECG finding characterized by J-point elevation and QRS notching or slurring in the inferior and/or lateral leads, yet little is known about its incidence and long-term prognosis in Asian populations. Methods and Results— We reviewed all the ECG records of the 5976 atomic-bomb survivors who were examined at least once during our biennial health examination in Nagasaki, Japan, between July 1958 and December 2004. We defined early repolarization pattern as ≥0.1-mV elevation of the J point or ST segment, with notching or slurring in at least 2 inferior and/or lateral leads. We assessed unexpected, cardiac, and all-cause death risk by Cox analysis. We identified 1429 early repolarization pattern cases (779 incident cases) during follow-up, yielding a positive rate of 23.9% and an incidence rate of 715 per 100 000 person-years. Early repolarization pattern had an elevated risk of unexpected death (hazard ratio, 1.83; 95% confidence interval, 1.12 to 2.97; P =0.02) and a decreased risk of cardiac (hazard ratio, 0.75; 95% confidence interval, 0.60 to 0.93; P &lt;0.01) and all-cause (hazard ratio, 0.85; 95% confidence interval, 0.78 to 0.93; P &lt;0.01) death. In addition, both slurring and notching were related to higher risk of unexpected death (hazard ratio, 2.09; 95% confidence interval, 1.06 to 4.12; P =0.03), as was early repolarization pattern manifestation in both inferior and lateral leads (hazard ratio, 2.50; 95% confidence interval, 1.29 to 4.83; P &lt;0.01). Conclusions— Early repolarization pattern is associated with an elevated risk of unexpected death and a decreased risk of cardiac and all-cause death. Specific early repolarization pattern morphologies and location are associated with an adverse prognosis.
Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: A Rochester Epidemiology Project population-based study in Minnesota
Authors: Jerry D. Brewer, Tait D. Shanafelt, Farzaneh Khezri, Ivette M. Sosa Seda, Adeel S. Zubair, Christian L. Baum, Christopher J. Arpey, James R. Cerhan, Timothy G. Call, Randall K. Roenigk, Carin Y. Smith, Amy L. Weaver, Clark C. Otley
Journal: Journal of the American Academy of Dermatology (2014)
Contempo '81. Genetics
Authors: R. L. Teplitz
Journal: JAMA (1981)

<h3>Gene Transfer Mechanisms</h3> Wouldn't it be useful if we knew how to transfer genetic material into cells at will? Obviously, one a[ill]m of such activity would be to provide a normal gene where one is deficient or lacking. Such an effort implies that the gene to be transferred is known, that there is a mechanism for placing it within the cell, safe from enzymatic attack, and that it can be inserted within the proper site in the genome, displacing a deficient or inoperable gene. While such experiments have not been completed successfully in mammalian cells, recombinant DNA techniques have shown that synthesis of appropriate genetic material is entirely practical. Recently, several methods for transferring genetic material into microorganisms, including deficient ones, have been reported.<sup>1,2</sup>Although the phenomenon of transfer has been known to occur spontaneously in bacteria, the mechanism has been elusive.<sup>1</sup>Now, its genetic character and control
Smoking and colonic mucus in ulcerative colitis.
Authors: G F Cope, R V Heatley, J K Kelleher
Journal: BMJ (1986)

Etude de la production de mucus par la muqueuse colique (biopsie) chez 82 malades atteints de colite ulcerative (71 non-fumeurs et 11 fumeurs) et 121 temoins (70 non-fumeurs et 51 fumeurs). La production de mucus est moindre dans la colite ulcerative, elle est plus leevee chez les fumeurs (elle est pratiquement normale chez les fumeurs atteints de colite). Argument possible en faveur de l'hypothese d'un effet protecteur de la nicotine contre la colite ulcerative
Incidence of HIV infection in homosexual men in London, 1988-94
Authors: E Miller, P A Waight, R S Tedder, S Sutherland, P P Mortimer, M S Shafi
Journal: BMJ (1995)

Measures of the incidence of HIV infection in different groups are essential for targeting and evaluating health education. Incidence measures obtained by the follow up of closed cohorts become biased over time as early infection in those at highest risk results in a subsequent downward trend in incidence.1 2 We describe changes in the age specific incidence of HIV infection in open cohorts of homosexual men continuously recruited from among patients attending genitourinary medicine clinics in London from 1988 to 1994.

View this table:

Incidence of HIV infection in HIV negative homosexual men by age and over time



Homosexual men negative for HIV antibody who had attended genitourinary medicine clinics in London from January 1988 to April 1994 and been voluntarily …
Acromegaly — A Stubborn Therapeutic Challenge
Authors: William H. Daughaday
Journal: New England Journal of Medicine (1970)

Early experience with radioimmunoassay established that plasma growth hormone (GH) remained elevated with high frequency in acromegalic patients who had received conventional x-ray treatment. Because of these findings the view has been prevalent that this form of treatment was virtually without benefit. In this issue of the Journal, Roth, Gorden and Brace argue that conventional irradiation is as good as other forms of treatment and is associated with fewer adverse reactions. Eighteen patients received 4000 to 4500 R by conventional supravoltage machines, and two patients were treated with cobalt irradiation. Plasma GH fell in nearly all. In patients followed . . .
<i>Lith</i>genes control mucin accumulation, cholesterol crystallization, and gallstone formation in A/J and AKR/J inbred mice
Authors: Frank Lammert, David Q.-H. Wang, Henning Wittenburg, Guylaine Bouchard, Sonja Hillebrandt, Bärbel Taenzler, Martin C. Carey, Beverly Paigen
Journal: Hepatology (2002)

We recently identified 2 Lith genes that determine cholesterol gallstone formation in C57L/J inbred mice, which show a gallstone prevalence of ˜80% on feeding 1.0% cholesterol and 0.5% cholic acid. The aim of this study was to explore if the same Lith loci contribute to the variation in gallstone susceptibility in a new experimental cross. After 12 weeks of feeding the lithogenic diet to inbred mice of strains A/J and AKR/J as well as their F 1 progeny, we used microscopy of bile to assess mucin accumulation, crystallization pathways, and stone formation. Backcross progeny (n = 225) were phenotyped and genotyped selectively for microsatellite markers spanning the genome. Quantitative trait loci (QTL) affecting gallstone phenotypes were identified by linkage analysis. Both inbred strains showed accumulation of mucin gel and cholesterol supersaturation. However, only strain AKR developed gallstones (prevalence of 20%), whereas strain A showed a stable liquid crystalline state and no stones. QTL analysis identified a gallstone locus on chromosome 17 ( Lith3 ). A second gene locus on chromosome 15 that controls mucin accumulation harbors the mucin gene Glycam1 , which was shown to be expressed in gallbladder epithelia by immunohistochemistry. Gallstone and mucin loci colocalized with potential QTLs affecting the formation of cholesterol crystals. In conclusion, QTL analysis identified specific gene loci determining mucin accumulation, cholesterol crystallization, and gallstone formation. Characterization of the pathophysiologic roles of Lith3 and the new biliary mucin gene Glycam1 might provide insights into primary defects of human cholelithiasis and lead to new therapeutic strategies for prestone intervention.
North Dakota surveys early onset diabetes
Authors: Phil Gunby
Journal: JAMA (1983)

The first known effort in this country to obtain epidemiologic data about early onset diabetes for an entire state is under way in North Dakota. So far, says James Brosseau, MD, associate professor of community medicine at the University of North Dakota School of Medicine, Grand Forks, about 300 patients younger than 19 years have been located. And results to date raise some interesting questions. For example, six counties, scattered around the state, have prevalence rates more than double the expected rate. Yet adjoining one of them is a county with no known cases of early onset diabetes despite the fact that it has about the same number of people, most of whom go to the same place for medical care, as its neighboring county. Also, while some studies have indicated seasonal variations in onset of this disease, with peaks in the winter months, the North Dakota data to date
Evidence-Based Physical Diagnosis
Authors: Michael Shawn Stinson
Journal: Annals of Internal Medicine (2001)

Medical Writings: Book Notes6 November 2001Evidence-Based Physical DiagnosisMichael Shawn Stinson, MDMichael Shawn Stinson, MDUniversity of South Carolina School of Medicine, Columbia, South Carolina.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-9-200111060-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail McGee S. 910 pages. Philadelphia: WB Saunders; 2001. $45.00. ISBN 0721686931. Order phone 800-545-2522.Field of medicine: General medicine and medical education.Format: Softcover book.Audience: General internists, medical educators, medical students, residents, and medical subspecialists seeking a concise reference on the diagnostic accuracy of many of the physical signs taught and used in bedside diagnosis.Purpose: To review the accuracy of commonly and infrequently used and taught physical diagnosis maneuvers, thereby providing the clinician with the necessary information to decide which are reliable diagnostic tools.Content: The book has 12 parts. Part 1 covers a brief review of basic ... Author, Article, and Disclosure InformationAffiliations: University of South Carolina School of Medicine, Columbia, South Carolina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe low‐harm score for predicting mortality in patients diagnosed with COVID‐19: A multicentric validation study 6 November 2001Volume 135, Issue 9Page: 846KeywordsClinical epidemiologyConfidence intervalsInformation technologyLikelihood ratioMedical educationSoftware toolsSub-specialty care ePublished: 6 November 2001 Issue Published: 6 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Electrophysiologic characteristics andimplications of induced ventricular fibrillationin symptomatic patients with brugada syndrome
Authors: Munetake Kanda, Wataru Shimizu, Kiyotaka Matsuo, Noritoshi Nagaya, Atsushi Taguchi, Kazuhiro Suyama, Takashi Kurita, Naohiko Aihara, Shiro Kamakura
Journal: Journal of the American College of Cardiology (2002)
Mitochondrial Bcl-2 Family Dynamics Define Therapy Response and Resistance in Neuroblastoma
Authors: Kelly C. Goldsmith, Michelle Gross, Susan Peirce, Dema Luyindula, Xueyuan Liu, Annette Vu, Michael Sliozberg, Rong Guo, Huaqing Zhao, C. Patrick Reynolds, Michael D. Hogarty
Journal: Cancer Research (2012)

Neuroblastoma is a childhood tumor in which transient therapeutic responses are typically followed by recurrence with lethal chemoresistant disease. In this study, we characterized the apoptotic responses in diverse neuroblastomas using an unbiased mitochondrial functional assay. We defined the apoptotic set point of neuroblastomas using responses to distinct BH3 death domains providing a BH3 response profile and directly confirmed survival dependencies. We found that viable neuroblastoma cells and primary tumors are primed for death with tonic sequestration of Bim, a direct activator of apoptosis, by either Bcl-2 or Mcl-1, providing a survival dependency that predicts the activity of Bcl-2 antagonists. The Bcl-2/Bcl-xL/Bcl-w inhibitor ABT-737 showed single-agent activity against only Bim:Bcl-2 primed tumor xenografts. Durable complete regressions were achieved in combination with noncurative chemotherapy even for highest risk molecular subtypes with MYCN amplification and activating ALK mutations. Furthermore, the use of unique isogenic cell lines from patients at diagnosis and at the time of relapse showed that therapy resistance was not mediated by upregulation of Bcl-2 homologues or loss of Bim priming, but by repressed Bak/Bax activation. Together, our findings provide a classification system that identifies tumors with clinical responses to Bcl-2 antagonists, defines Mcl-1 as the principal mediator of Bcl-2 antagonist resistance at diagnosis, and isolates the therapy resistant phenotype to the mitochondria.
Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study
Authors: S A Stanner, K Bulmer, C Andres, O E Lantseva, V Borodina, V V Poteen, J S Yudkin
Journal: BMJ (1997)

To investigate the relation between decreased maternal food intake and risk factors for coronary heart disease in adult life.Cross sectional study.169 subjects exposed to malnutrition in utero (intrauterine group) during the siege of Leningrad (now St Petersburg) in 1941-4; 192 subjects born in Leningrad just before rationing began, before the siege (infant group); and 188 subjects born concurrently with the first two groups but outside the area of the siege (unexposed group).Ott Institute of Obstetrics and Gynaecology, St Petersburg.Development of risk factors for coronary heart disease and diabetes mellitus-obesity, blood pressure, glucose tolerance, insulin concentrations, lipids, albumin excretion rate, and clotting factors.There was no difference between the subjects exposed to starvation in utero and those starved during infant life in: (a) glucose tolerance (mean fasting glucose: intrauterine group 5.2 (95% confidence interval 5.1 to 5.3), infant group 5.3 (5.1 to 5.5), P = 0.94; mean 2 hour glucose: intrauterine group 6.1 (5.8 to 6.4), infant group 6.0 (5.7 to 6.3), P = 0.99); (b) insulin concentration; (c) blood pressure; (d) lipid concentration; or (e) coagulation factors. Concentrations of von Willebrand factor were raised in the intrauterine group (156.5 (79.1 to 309.5)) compared with the infant group (127.6 (63.9 to 254.8); P < 0.001), and female subjects in the intrauterine group had a stronger interaction between obesity and both systolic (P = 0.01) and diastolic (P = 0.04) blood pressure than in the infant group. Short adult stature was associated with raised concentrations of glucose and insulin 2 hours after a glucose load-independently of siege exposure. Subjects in the unexposed group had non-systematic differences in subscapular to triceps skinfold ratio, diastolic blood pressure, and clotting factors compared with the exposed groups.Intrauterine malnutrition was not associated with glucose intolerance, dyslipidaemia, hypertension, or cardiovascular disease in adulthood. Subjects exposed to malnutrition showed evidence of endothelial dysfunction and a stronger influence of obesity on blood pressure.
Reduced Incidence of Intraoperative Complications in a Multicenter Controlled Clinical Trial of Triamcinolone in Vitrectomy
Authors: Keita Yamakiri, Taiji Sakamoto, Yoshihiro Noda, Masaaki Nakahara, Nobuchika Ogino, Toshiaki Kubota, Mitsunobu Yokoyama, Mariko Furukawa, Yasushi Sonoda, Tomomi Yamada, Norihito Doi, Hiroshi Enaida, Yasuaki Hata, Tatsuro Ishibashi
Journal: Ophthalmology (2007)