TRANSMISSIBILITY OF LEUKEMIA
Authors: PAUL W. CLOUGH
Journal: Annals of Internal Medicine (1954)

Editorial1 November 1954TRANSMISSIBILITY OF LEUKEMIAPAUL W. CLOUGHPAUL W. CLOUGHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-5-1084 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe etiology of leukemia is an unsolved problem which has stimulated much study and speculation. Leukemia resembles malignant neoplasms in many obvious ways, and it has come to be regarded by most students as essentially a neoplastic process. Recent work, on the other hand, has emphasized the possibility that a living (infectious) agent may be concerned. These views, indeed, are not irreconcilable nor mutually exclusive. The occurrence of a disease closely resembling human leukemia not only in chickens and related birds but also in mice has made extensive experimental studies possible.That leukemia in chickens can be transmitted in the...1 EllermannBang VO: Experimentelle Leukämie bei Hühnern, Centralbl. f. Bakt. I Abt. Orig. 46: 595-609, 1908. Google Scholar2 Waters NF: The contagious nature of a lymphoid tumor in chickens, Science 106: 246-248, 1947 (Sept. 12). CrossrefMedlineGoogle Scholar3 WatersBywaters NFJH: Influence of age of chickens at contact exposure on incidence of lymphomatosis, Poultry Science 28: 254, 1949. CrossrefGoogle Scholar4 Gross L: The "vertical" transmission of mouse mammary carcinoma and chicken leukemia, Cancer 4: 626-633, 1951. CrossrefMedlineGoogle Scholar5 Bittner JJ: The causes and control of mammary cancer in mice, Harvey Lect. Series 42, 221-246, 1946-47. Google Scholar6 Gross L: The vertical epidemic of mammary cancer in mice, Surg., Gynec. and Obst. 88: 295-308, 1949. MedlineGoogle Scholar7 Gross L: Is leukemia caused by a transmissible virus? A working hypothesis, Blood 9: 557-573, 1954. CrossrefMedlineGoogle Scholar8 Gross L: Pathogenic properties and "vertical" transmission of the mouse leukemia agent, Proc. Soc. Exper. Biol. and Med. 78: 342-348, 1951. CrossrefMedlineGoogle Scholar9 Gross L: Biologic properties of the mouse leukemia agent, Cancer 6: 153-158, 1953. CrossrefGoogle Scholar10 Gross L: Spontaneous mouse leukemia developing in C3H mice following inoculation in infancy with AK leukemic extracts or AK embryos, Proc. Soc. Exper. Biol. and Med. 76: 27-32, 1951. CrossrefMedlineGoogle Scholar11 Gross L: Presence of leukemia agent in normal testes and ovaries of young mice of AK line, Acta Haemat. 10: 18-26, 1953. CrossrefMedlineGoogle Scholar12 Furth J: Analytical review: Recent studies of the etiology and nature of leukemia, Blood 6: 964-975, 1951. CrossrefMedlineGoogle Scholar13 Gross L: Neck tumors or leukemia developing in adult C3H mice following inoculation in early infancy with filtered (Berkefeld N) or centrifugated (144, 000 X g) AK-leukemic extracts, Cancer 6: 948-957, 1953. CrossrefMedlineGoogle Scholar14 Stewart SE: Leukemia in mice produced by a filterable agent present in AK leukemic tissues with notes on a sarcoma produced by the same agent, Anat. Rec. 117: 532, 1953 (Abst.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1954Volume 41, Issue 5Page: 1084-1088KeywordsEtiology Issue Published: 1 November 1954 PDF DownloadLoading ...