Goodpasture's Syndrome
Authors: THOMAS R. POSKITT
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 August 1975Goodpasture's SyndromeTHOMAS R. POSKITT, M.D.THOMAS R. POSKITT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-2-283_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent paper by Mathew and associates (Ann Intern Med 82:215-218, 1975), reporting a case of Goodpasture's syndrome without clinical evidence of renal disease, raises several questions concerning interpretation of the data.The patient was an 18-year-old man with a history of hemoptysis, iron deficiency anemia, and hemosiderin-laden pulmonary macrophages, who was treated with corticosteroids with resolution of the hemoptysis. Despite the absence of hematuria, proteinuria, or renal functional impairment, the patient underwent three renal biopsies in 4 months, all of which failed to show evidence of glomerulitis by light microscopy. On the basis of IgG and...References1. KOFFLERAGNELLOCARR DVR: Variable patterns of immunoglobulin and complement deposition in the kidneys of patients with systemic lupus erythematosus. Am J Pathol 56:305-312, 1969 MedlineGoogle Scholar2. GERMUTHRODRIGUEZ FE: Immunopathology of the Renal Glomerulus. Boston, Little, Brown and Company, 1973, pp. 123-134 Google Scholar3. SUTHERLANDVANN MARKHAMMARDINEY JRM: Subclinical immune complexes in the glomeruli of kidneys postmortem. Am J Med 57:536-541, 1974 CrossrefMedlineGoogle Scholar4. BURNSMACIVER JA: Immuno-electron microscopy of the glomerular basement membrane in Goodpasture's syndrome. Rev Eur Etud Clin Biol 16:48-50, 1971 MedlineGoogle Scholar5. POSKITT T: Immunologic and electron microscopic studies in Goodpasture's syndrome. Am J Med 49:250-257, 1970 CrossrefMedlineGoogle Scholar6. See Reference 2, p. 199 Google Scholar7. BYRDTRANK RG: Systemic lupus erythematosis presenting as pulmonary hemosiderosis. Chest 64:128-129, 1973 CrossrefMedlineGoogle Scholar1. DUNCANDRUMMONDMICHAEL DKA: Pulmonary hemorrhage and glomerulonephritis: report of six cases and study of the renal lesion by the fluorescent antibody technique and electron microscopy. Ann Intern Med 62:920-938, 1965 LinkGoogle Scholar2. MARQUARDTWILSONDIXON HCF: Isolation and immunological characterization of human glomerular basement membrane antigens. Kidney Int 3:57-65, 1973 CrossrefMedlineGoogle Scholar1. DUNCANDRUMMONDMICHAEL DKA: Pulmonary hemorrhage and glomerulonephritis. Ann Intern Med 62:920-938, 1965 LinkGoogle Scholar2. POSKITT T: Immunologic and electron microscopic studies in Goodpasture's syndrome. Am J Med 49:250-257, 1970 CrossrefMedlineGoogle Scholar3. BURKHOLDER P: Atlas of Human Glomerular Pathology. Hagerstown, Maryland, Harper & Row, 1974, p 224 Google Scholar1. SOERGELSOMMERS KS: Idiopathic pulmonary haemosiderosis and related syndrome. Am J Med 32:499-511, 1962 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS R. POSKITT, M.D.Affiliations: Department of Medicine New England Center Hospital Boston, Massachusetts 02111 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGlomerulitis 1 August 1975Volume 83, Issue 2Page: 283-284KeywordsBiopsyGlomerulonephritisIron deficiency anemiaLight microscopyMacrophagesProteinuriaRenal diseases ePublished: 1 December 2008 Issue Published: 1 August 1975 PDF downloadLoading ...