Controlling the Troll
Authors: Andre C. Kalil, Elizabeth Lyden, Julie Stoner
Journal: Annals of Internal Medicine (2006)

Letters21 March 2006Controlling the TrollAndre C. Kalil, MD, Elizabeth Lyden, MS, and Julie Stoner, PhDAndre C. Kalil, MDFrom the University of Nebraska, Nebraska Medical Center, Omaha, NE 68198-5400.Search for more papers by this author, Elizabeth Lyden, MSFrom the University of Nebraska, Nebraska Medical Center, Omaha, NE 68198-5400.Search for more papers by this author, and Julie Stoner, PhDFrom the University of Nebraska, Nebraska Medical Center, Omaha, NE 68198-5400.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-6-200603210-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read Dr. Dummer's editorial (1) about our study (2) with interest. However, we would like to make some clarifications.We agree with Dr. Dummer's recommendation that because of potential confounding factors related to differing outcomes in the preemptive and prophylactic trials, “it would be unwise to directly compare the results achieved with the 2 strategies.” Our study made no such formal, direct comparisons. In the Discussion section, we clearly stated that comparison of these 2 approaches needs to be based on a “prospective trial directly comparing universal prophylaxis with a preemptive approach.”Dr. Dummer stated that ...References1. Dummer S. Controlling the troll: management of cytomegalovirus infection after transplantation [Editorial]. Ann Intern Med. 2005;143:913-4. [PMID: 16365473] LinkGoogle Scholar2. Kalil AC, Levitsky J, Lyden E, Stoner J, Freifeld AG. Meta-analysis: the efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients. Ann Intern Med. 2005;143:870-80. [PMID: 16365468] LinkGoogle Scholar3. Hibberd PL, Tolkoff-Rubin NE, Conti D, Stuart F, Thistlethwaite JR, Neylan JF, et al. Preemptive ganciclovir therapy to prevent cytomegalovirus disease in cytomegalovirus antibody-positive renal transplant recipients. A randomized, controlled trial. Ann Intern Med. 1995;123:18-26. [PMID: 7762909] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Andre C. Kalil, MD; Elizabeth Lyden, MS; Julie Stoner, PhDAffiliations: From the University of Nebraska, Nebraska Medical Center, Omaha, NE 68198-5400.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPreemptive Ganciclovir Therapy To Prevent Cytomegalovirus Disease in Cytomegalovirus Antibody-Positive Renal Transplant Recipients Patricia L. Hibberd , Nina E. Tolkoff-Rubin , David Conti , Frank Stuart , J. Richard Thistlethwaite , John F. Neylan , David R. Snydman , Richard Freeman , Marc I. Lorber , and Robert H. Rubin Controlling the Troll: Management of Cytomegalovirus Infection after Transplantation Stephen Dummer Meta-Analysis: The Efficacy of Strategies To Prevent Organ Disease by Cytomegalovirus in Solid Organ Transplant Recipients Andre C. Kalil , Josh Levitsky , Elizabeth Lyden , Julie Stoner , and Alison G. Freifeld Controlling the Troll Stephen Dummer Metrics 21 March 2006Volume 144, Issue 6Page: 457-458KeywordsClinical trialsConflicts of interestCytomegalovirus infectionProphylaxisQualitative studiesStatistical methods ePublished: 21 March 2006 Issue Published: 21 March 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...