tbuckley/cabot-search huggingface dataset:
Evidence for serotonin as a relevant inducer of liver regeneration after liver resection in humans
Authors: Patrick Starlinger, Alice Assinger, Stefanie Haegele, David Wanek, Silvia Zikeli, Dominic Schauer, Peter Birner, Edith Fleischmann, Birgit Gruenberger, Christine Brostjan, Thomas Gruenberger
Journal: Hepatology (2013)

Liver regeneration (LR) involves a complex interplay of growth factors and antagonists. In this context, platelet-derived serotonin (5-HT) has been identified as a critical inducer of LR in mice. Clinical evidence for a role of 5-HT in LR in humans is lacking. Accordingly, serum and plasma 5-HT was monitored perioperatively in 60 patients undergoing liver resection, of which 35 served as exploration and 25 as validation sets. Intraplatelet (IP) levels of 5-HT were calculated by subtraction of plasma 5-HT from serum values. Serum markers of liver function were used to evaluate LR and liver dysfunction (LD). In the exploration setting, IP 5-HT levels significantly decreased after liver resection (P < 0.001) and gradually recovered during the first week. IP 5-HT measured before surgery specifically predicted LD in the subsequent 7 days (area under the curve: 0.721; P = 0.029). Patients suffering from postoperative LD and morbidity were found to have reduced IP 5-HT levels during the entire perioperative period. Furthermore, we validated that reduced preoperative IP 5-HT (<73 ng/mL) was associated with an increased incidence of postoperative LD and morbidity (P = 0.045 and P = 0.021) and were able to demonstrate that IP 5-HT levels were an independent predictor of poor clinical outcome.These findings provide evidence that IP 5-HT correlates with LR in humans: Patients with low IP 5-HT before liver resection suffered from delayed hepatic regeneration. Therefore, IP 5-HT levels may prove a helpful clinical marker to predict postoperative LD and clinical outcome before hepatic resection and initiate suitable interventions.
TRIC-A Channels in Vascular Smooth Muscle Contribute to Blood Pressure Maintenance
Authors: Daiju Yamazaki, Yasuharu Tabara, Satomi Kita, Hironori Hanada, Shinji Komazaki, Daisuke Naitou, Aya Mishima, Miyuki Nishi, Hisao Yamamura, Shinichiro Yamamoto, Sho Kakizawa, Hitoshi Miyachi, Shintaro Yamamoto, Toshiyuki Miyata, Yuhei Kawano, Kei Kamide, Toshio Ogihara, Akira Hata, Satoshi Umemura, Masayoshi Soma, Norio Takahashi, Yuji Imaizumi, Tetsuro Miki, Takahiro Iwamoto, Hiroshi Takeshima
Journal: Cell Metabolism (2011)
No Association Between the MTHFR Gene Polymorphism and Diabetic Retinopathy in Type 2 Diabetic Patients Without Overt Nephropathy
Authors: Keiji Yoshioka, Toshihide Yoshida, Yasuto Takakura, Akinori Kogure, Tsunekazu Umekawa, Hitoshi Toda, Toshikazu Yoshikawa
Journal: Diabetes Care (2003)

Maeda et al. (1) have recently demonstrated that the presence of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in diabetic patients can be a predictive for diabetic retinopathy (DR), especially nonproliferative DR (NPDR). We also genotyped the MTHFR polymorphism (C677T) in 366 type 2 diabetic patients without overt nephropathy, and no such association was found. The subjects had a mean age of 60.0 years, duration of diabetes of 11.7 years, HbA1c of 7.3%, and serum creatinine of 0.71 mg/dl. The patients with urinary …
Walter Henry Chapin
Authors: Allen G. Rice
Journal: New England Journal of Medicine (1956)

WALTER Henry Chapin was a very learned physician. His inquisitive mind and his burning thirst for knowledge drove him into many fields. He was no dilettante. Into whatever realm of learning he ventured — and they were many — he delved deeply until he outdid many a man whose special field he invaded.Born in Springfield, Massachusetts, on March 6, 1859, Dr. Chapin added renown to a family name illustrious in the annals of that city. He received from Yale College the degree of A.B. in 1880, and from the College of Physicians and Surgeons (Columbia) the degree of M.D. . . .
TCT-91 MitraClip-Induced Acute Changes in Renal Function Impact Mortality in Surgical High-Risk Patients with Significant Mitral Regurgitation
Authors: Edith Lubos, Daniel Lubs, Michael Schlüter, Mareike Donner, Georg Sander, Johannes Schirmer, Lenard Conradi, Hendrik Treede, Hermann Reichenspurner, Stephan Baldus, Volker Rudolph, Stefan Blankenberg, Britta Goldmann
Journal: Journal of the American College of Cardiology (2013)
Maturation of interdependence between extra-alveolar arteries and lung parenchyma in piglets.
Authors: A L Mansell, A L McAteer, A C Pipkin
Journal: Circulation Research (1992)

Mechanical interdependence between intrapulmonary structures and parenchyma has not been studied previously in immature postnatal lungs. To study these interactions, lung elastic moduli were measured by pressure-volume and punch indentation studies in lobes excised from 3-day-old (n = 6), 1-month-old (n = 6), and 3-month-old (n = 7) piglets. After extra-alveolar arteries were filled with a radiopaque fluid silicone compound, transpulmonary pressure and arterial pressure were varied independently as the lobar vein was occluded. Arterial diameters and lengths were measured from radiographs. Behavior of 3-month-old lungs was consistent with previous studies of adult lungs, but results were unique in 3-day-old lungs. That is, during stepwise deflation of the immature lungs 1) intravascular pressures fell when arteries were occluded experimentally, 2) arteries increased their diameters when kept at a constant intravascular pressure, and 3) arterial lengths decreased by less than 3%. Behavior of 1-month-old lungs was intermediate. A previous continuum mechanics analysis of pressure-diameter behavior was modified to account for compression by alveolar pressure as vascular diameters increase. It was concluded that 1) radial and axial dimensions of extra-alveolar arteries are virtually independent of parenchymal expansion in newborn piglet lungs and 2) periarterial interstitial pressures increase as these lungs are inflated. Our interpretation of these findings is that a mechanical association of the arteries to the parenchyma occurs gradually with postnatal maturation.
Ethics of Proxy Consent for Research Involving Patients With Adult Respiratory Distress Syndrome-Reply
Authors: Ronald B. Hirschl
Journal: JAMA (1996)

<h3>In Reply.</h3> —Every day, practicing physicians are faced with obtaining "surrogate" consent for procedures and interventions from parents of minor children, foster parents, social service workers, those with power of attorney, family members, and legal guardians who make decisions on behalf of patients who are unable to do so for themselves. We rely on these advocates for the patient to represent the patient's interests in all aspects of their medical care, including the application of new operative and medical treatment. Is there a substantial difference between obtaining informed consent from the patient's representative for standard care or for an innovative treatment? We submit that there is not: in all cases, the tenets of informed consent, including the details of the procedure and the potential risks and benefits and alternatives, must be explained thoroughly in an understandable language to a patient advocate who can represent the interest of the currently incompetent patient. Our
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
Authors: Chunaram Choudhary, Joachim Schwäble, Christian Brandts, Lara Tickenbrock, Bülent Sargin, Thomas Kindler, Thomas Fischer, Wolfgang E. Berdel, Carsten Müller-Tidow, Hubert Serve
Journal: Blood (2005)
Epidemiology of Penicillinase-Producing<i>Neisseria gonorrhoeae</i>Infections
Authors: H. Hunter Handsfield, Eric G. Sandström, Joan S. Knapp, Peter L. Perine, William L. Whittington, Dennis E. Sayers, King K. Holmes
Journal: New England Journal of Medicine (1982)

Auxotyping and serogrouping by coagglutination were used to characterize penicillinase-producing Neisseria gonorrhoeae and penicillinase-negative isolates from the state of Washington, Shreveport (Louisiana), and the Far East. Fifty-four of 75 penicillinase-producing isolates (72 per cent) from Washington required proline for growth and were serogroup W-l (Pro-1), the predominant type of penicillinase-producing strains in the Philippines; none of 86 penicillinase-negative isolates from Washington was Pro-1 (P less than 0.0001). All 38 penicillinase-producing isolates from Shreveport required proline and were serogroup W-11 (Pro-11); five of 26 penicillinase-negative isolates (19 per cent) from Shreveport were also Pro-11 (P less than 0.0001) but had antigenic specificities within serogroup W-ll that distinguished them from the penicillinase-producing isolates. We conclude that the Washington and Shreveport outbreaks resulted from the spread of imported strains rather than transmission of penicillinase-encoding plasmids to indigenous gonococci. The Shreveport outbreak involved a single strain of penicillinase-producing N, gonorrhoeae and probably originated from a common source, whereas several types were involved in the multiple-source Washington outbreak, indicating repeated introduction of new strains.
Components of health: an analysis in rheumatoid arthritis using quality of life questionnaires and clinical and laboratory variables.
Authors: M Borstlap, M van de Laar, J Zant, J van der Korst
Journal: Annals of the Rheumatic Diseases (1993)

OBJECTIVE--To gain insight into the overlap between additional information supplied by recently developed health status instruments for rheumatoid arthritis (RA) and traditional clinical and laboratory tests. METHODS--A cross sectional study of 282 outpatients with RA was made. From each patient, variables of clinical and laboratory measurements were obtained and the modified health assessment questionnaire (MHAQ) and a Dutch quality of life questionnaire, the IRGL, were completed. These variables were analysed for their interrelationship. RESULTS--Clinical and laboratory variables correlated significantly with the scales of the physical dimension and the disease impact scale of the IRGL. Their significant correlations with the IRGL psychological scales were weak. There were no significant correlations between any of the traditional variables and the IRGL social scales. Factor analysis yielded five factors: functionality, pain, depressive mood, social support, and laboratory. The laboratory factor is a measure of the disease process. The other four factors provide a health model. CONCLUSION--The results suggest that the IRGL questionnaire that was studied covers a complete health model that incorporates aspects of health that are not measured by clinical and laboratory tests. A simple questionnaire for the psychological and social dimension of health status, however, would probably be more cost effective and easier to use in clinical practice.
Coarctation of the aorta associated with aortic valvular atresia.
Authors: T J Von Rueden, L Knight, J H Moller, J E Ewards
Journal: Circulation (1975)

The aortas in 41 specimeans of aortic atresia (ten with associated mitral atresia) were studied for the presence of coarctation of the aorta. The basic lesion, causing varying degrees of obstruction, was observed in 31 instances (75%), 24 minor, seven with major degrees of obstruction. In half, the aortic lesion lay proximal to the ductus, and in the majority of the remainder, opposite the ductus arteriosus. The location of lesion and degree of obstruction was essentially the same whether aortic atresia occurred alone or in association with mitral atresia. Angiography is a fairly reliable method of identifying coarctation associated with aortic atresia. An additional point of interest was that in aortic atresia alone there was strong dominance of the male sex, while this tendency was not observed when mitral atresia was associated with aortic atresia.
The General Medical Council and the future of revalidation: Revalidation, discretionary points, clinical excellence awards—steps on the same ladder
Authors: Anton E A Joseph
Journal: BMJ (2005)

The General Medical Council and the future of revalidation GMC member respondsEditor-Esmail and Kmietowicz give an inaccurate account of the General Medical Council's policy development on revalidation, ignoring an iterative process with interested parties since 1998 in an attempt to introduce the most fundamental change to medical regulation since its foundation in 1858. 1 2 The GMC clearly has had regard to the legitimate interests of three principal groups-government and the NHS, patients and the public, and the various tribes that make up the UK medical profession.Despite suggestions to the contrary, an initial exploratory meeting on revalidation convened by Sir Donald Irvine in June 1998 was held in the context of a high profile professional conduct case, but well before the Bristol inquiry report and absolutely nothing to do with Rodney Ledward or, indeed, Harold Shipman.It was recognised then that some doctors were not keeping fully up to date nor were they indulging in reflective practice.Irvine correctly proposed that there was a need to make registration with the GMC more meaningful to the public than a mere recognition that doctors had reached a certain standard of professional knowledge in their early 20s.Both articles promote the idea that the doctors' regulator should be filling the vacuum within the NHS created by its failing to fulfil its public responsibility to monitor doctors' clinical standards.Clinical governance is now, slowly, being developed and eventually will extend from systems and teams to individuals-but is it reasonable, as both authors postulate, that such monitoring should become the financial and moral responsibility of the GMC sitting in London and Manchester rather than local managers at the coalface?Although revalidation is a continuing process, it becomes summative only every five years.The NHS and its local systems must not be allowed to abrogate their responsibility for the safety of patients on a day to day basis.Nor should they demand that the GMC and its prime function of assuring fitness to practise and the meaning of the medical register be inappropriately promoted as the first line of defence for the maintenance of clinical quality and safety.
Abstract 1805: Integration of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) in combinational immunotherapy targeting tumor antigen EphA2
Authors: Aparna Rao, Mayumi Kawabe, Walter J. Storkus
Journal: Cancer Research (2011)

Abstract Introduction: EphA2 and HSP90 play important roles in tumor growth, survival and metastasis. An effective therapeutic approach would promote decreased expression of EphA2 on tumor cells, while increasing presentation of EphA2-derived peptides on tumor MHC class I complexes, thereby enhancing the recognition of tumors by anti-EphA2 CD8+ T effector cells. Aim: We are assessing the safety and effectiveness of the HSP90 inhibitor 17-DMAG in enhancing anti-tumor immunotherapy with EphA2-specific T cells in murine tumor models. Methods: We tested the effect of 17-DMAG on tumor cell expression of EphA2 and the MHC I antigen-processing machinery in vitro. Efficacy of 17-DMAG in an MCA205 sarcoma model was also evaluated in vivo. Results: 17-DMAG facilitated a dose-dependent reduction in EphA2 expression, but had no adverse effects on the antigen-processing machinery of the tumors. Similar effects were seen in an MCA205 sarcoma model in vivo, where reduction in EphA2 levels in tumors corresponded with increased recognition by EphA2-specific CD8+ T cells in vitro. 17-DMAG treatment also facilitated increased infiltration of CD4 and CD8 T cells in the tumor, compared to untreated cohorts. Conclusion: 17-DMAG treatment promotes immunologically-preferred alterations tumor cells in vitro as well as In vivo. Our preliminary in vivo studies suggest that decreased EphA2 levels in tumors is accompanied by increased presentation of EphA2 peptides in tumor MHC class I complexes. Further in vivo studies are warranted to assess the net anti-tumor impact of combinational immunotherapies integrating 17-DMAG. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1805. doi:10.1158/1538-7445.AM2011-1805
The Selection of Residents-Reply
Authors: Robert L. Volle
Journal: JAMA (1988)

<h3>In Reply.</h3> —Dr Mindel has misstated some of my editorial remarks on the use of Part I National Board scores in the selection of residents. Nowhere does the editorial comment on the use by ophthalmology programs of Part I National Board scores; Dr McCollister does so in his article.<sup>1</sup>The intent of the editorial was to caution program directors and others about the limitations of Part I of the National Board examinations, not to advise program directors about their selection methods. Equally important, nowhere does the editorial make the claim that performance on Part I reflects academic achievement that can be related to the quality of later professional life. What was said was that academic achievement in general is held by conventional wisdom to relate to the quality of later professional life, ie, students who do well in high school do well in college, etc. The point being made
VISUALIZATION OF THE GALLBLADDER BY THE SODIUM SALT OF TETRABROMPHENOLPHTHALEIN
Authors: EVARTS A. GRAHAM
Journal: JAMA (1924)

Since the publication of an article a few weeks ago by two of us<sup>1</sup>on the production of roentgen-ray shadows of the gallbladder, a more satisfactory method has been developed by using the sodium salt of tetrabromphenolphthalein, instead of the calcium salt. The sodium salt is much more soluble. We are now using only from 35 to 40 c.c. of solution instead of 350 c.c. required by the calcium salt. It is much more stable, and is not crystallized out by sterilization. The first several injections of the calcium salt, as stated in our previous publication, produced no reaction. However, it was found later that a large proportion of the patients had reactions, which were characterized by headache, backache, nausea and vomiting, which lasted from ten minutes to ten hours. There were never any significant changes in pulse or blood pressure. The sodium salt was found to produce much
Theme Issue on Access to Health Care
Authors: Drummond Rennie, Phil B. Fontanarosa
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
905. The Use of Gene Immunisation To Study the Role of Antibodies to Voltage Gated Potassium Channels in Neuroimmunological Disease
Authors: Mary McMenamin, Karen M. McKnight, Matthew J.A. Wood, Bethan Lang, Nikki J. Horwood, Angela C. Vincent
Journal: Molecular Therapy (2006)

Recently, autoantibodies have been considered to be important in some CNS diseases. There is evidence of autoantibodies being detected in sera of patients with epileptic syndromes, particularly antibodies to voltage gated potassium channels (VGKCs). VGKCs are feasible targets for autoimmune attack as they are transmembrane proteins, expressed on the cell surface, controlling repolarisation and frequency of action potentials in neurons, muscles and other excitable cells. This work involves an attempt to create an animal model of autoimmune disease using gene immunisation to induce an antibody response to a VGKC sub-unit (Kv1.2). An adenoviral vector is used to over-express the immunogen (Kv1.2) as this combines the benefit of delivering a foreign antigen and an infectious agent. Viral vectors are particularly attractive for this puirpose since they mimic natural infection and can induce potent immune responses. The hypothesis is that antibodies raised in this way could potentially cross the blood-brain barrier and cause autoimmune disease by reacting with potassium channels in brain. In preliminary studies, in which mice were inoculated sub-cutaneously with an adenoviral vector expressing GFP, elevated levels of antibodies to GFP were detected in almost all mice inoculated with AdGFP at titres of 107 and 108 pfu in 2 strains of animal. In experiments in which mice were inoculated with an adenoviral vector expressing both GFP and the Kv1.2 sub-unit (AdGFP/HBK5) elevated antibody levels to both GFP and Kv1.2 were detected in some mice. In separate experiments a viral vector expressing NF-kB inducing kinase (NIK), to induce expression of the transcription factor NF-kB (AdNIK), was inoculated together with a vector expressing the Kv1.2 sub-unit (Ad/HBK5). Again elevated levels of antibodies and to Kv1.2 could be detected. There is variation between animals but this work shows that it is possible to induce auto antibodies in mice to foreign antigens in this way.
Menopause in Japanese Women
Authors: Margaret Lock
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The review by Dr Perlmutter<sup>1</sup>of my book,<i>Encounters With Aging: Mythologies of Menopause in Japan and North America</i>, has so many factual errors in it that I must set the record straight. I did not "interview more than 100 Japanese women over 20 years" or make use for comparative purposes of "published reports or material that had already been gathered and that had utilized other instruments." In fact, a questionnaire was distributed to over 1300 Japanese women, and I interviewed 105 of those same women over the course of 1 year. Contrary to what Perlmutter says, the questionnaire was exactly the same— apart from necessary cultural modifications—as the one used for large samples of Massachussetts and Manitoban women by my colleagues Drs Sonja McKinlay and Patricia Kaufert, respectively, with whom I worked closely at all stages of the survey research. As stated in my book,
Management of the Asymptomatic Patient With an Abnormal Exercise ECG
Authors: Lawrence J. Laslett, Ezra A. Amsterdam
Journal: JAMA (1984)

The "positive" stress ECG in an asymptomatic individual should be interpreted cautiously, using both the details of the test results and details of the clinical history. The central concept that this test, in conjunction with the patient's clinical situation, does not yield an absolute answer regarding the presence of coronary artery disease, but rather a likelihood of the presence or absence of disease, forms the basis of this interpretation and the framework in which to make decisions regarding the advisability of further testing. In general, those asymptomatic individuals with a low posttest probability of disease should be followed clinically, those with an intermediate likelihood or strong personal concern should undergo further noninvasive testing, and only in those few with a high likelihood of disease after stress ECG testing should immediate coronary angiography be considered.