tbuckley/cabot-search huggingface dataset:
Trumpets at Her Bedside
Authors: Margaret Roberts
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sending Croatian and Bosnian Children for Treatment Abroad
Authors: Darko Richter
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The armed conflict in Croatia in 1991 and 1992 has resulted in an estimated 13000 killed and 30000 wounded. Of these, 157 (1.2%) and 669 (2.2%), respectively, were children.<sup>1</sup>Forty-one children lost both parents and 5724 lost one.<sup>1</sup>There were 250 000 internally displaced persons. Later in 1992, about 400 000 Bosnian refugees settled in Croatia.<sup>2</sup>Children make up an estimated 35% of the internally displaced population and 56% of the refugee population. The hospital pediatric capacity of Croatia is 1800 beds. Refugee children accounted for 20% of emergency department visits and 30% of hospitalized children (unpublished data from the Department of Pediatrics, University Hospital Center, Zagreb, Croatia). Due to the scarcity of resources it has become increasingly difficult to maintain the prewar level of medical care. The Committee for the Coordination of Relief and Health Care for Children was charged with sending pediatric
Evolution of gene families and relationship with organismal evolution: rapid divergence of tissue-specific genes in the early evolution of chordates
Authors: N. Iwabe, K. Kuma, T. Miyata
Journal: Molecular Biology and Evolution (1996)

To determine a possible relationship between organismal and molecular evolution, the divergence patterns of gene families were examined by taking special notice of functional difference, tissue distribution, and intracellular localization of the members. A phylogenetic analysis of 25 different gene families revealed interesting patterns of divergence of these families: Most gene duplications giving rise to different functions antedate the vertebrates-arthropods separation. On the other hand, in a group of members carrying virtually identical function to one another but differing in tissue distribution (tissue-specific isoform), most gene duplications have occurred independently in each of vertebrates and arthropods after the separation of the two animal groups. In family members encoding molecules localizing in cell compartments (compartmentalized isoforms), the gene duplications antedate the animals-fungi separation. In the cases of the Ca2+ pump and rab subfamilies, the compartmentalized isoforms were shown to have diverged during the early evolution of eukaryotes. A phylogenetic analysis of the tissue-specific isoforms from 26 different subfamilies revealed extensive gene duplications and rapid rates of amino acid substitutions in the early evolution of chordates before the separation of fishes and tetrapods. On the contrary, the genetic variations are relatively low in the later period. This pattern of evolution observed at the molecular level is correlated well with that of tissue evolution based on fossil evidence and morphological data, and thus evolution at the two levels may be related.
Inhaled Zanamivir for the Prevention of Influenza in Families
Authors: Frederick G. Hayden, Larisa V. Gubareva, Arnold S. Monto, Thomas C. Klein, Michael J. Elliott, Janet M. Hammond, Stephen J. Sharp, Michael J. Ossi
Journal: New England Journal of Medicine (2000)

As prophylaxis against influenza in families, amantadine and rimantadine have had inconsistent effectiveness, partly because of the transmission of drug-resistant variants from treated index patients. We performed a double-blind, placebo-controlled study of inhaled zanamivir for the treatment and prevention of influenza in families.
Physiology of Thrombospondin
Authors: Deane F. Mosher
Journal: Annual Review of Medicine (1990)

Thrombospondin is a large, multifunctional glycoprotein released from activated platelets and secreted by growing cells. It binds to components of the cell surface and extracellular milieu. Thrombospondin probably modulates a number of processes, including aggregation of platelets, formation and lysis of fibrin, adhesion and migration of cells, and progression of cells through the growth cycle. Studies relating thrombospondin to disease processes are just beginning.
Renal Tubular Acidosis in Leprosy
Authors: David J. Drutz, Robert A. Gutman
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 September 1971Renal Tubular Acidosis in LeprosyDAVID J. DRUTZ, M.D., ROBERT A. GUTMAN, M.D.DAVID J. DRUTZ, M.D.Search for more papers by this author, ROBERT A. GUTMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-3-475_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Talal's comments regarding the relationship of renal tubular acidosis to peritubular infiltration of lymphocytes (1) are of particular interest to us because of studies we have recently completed relative to the incidence of impaired distal tubular acidification mechanisms in patients with leprosy. While stationed with U.S. Naval Medical Research Unit #2 (NAMRU-2) in Taipei, Taiwan, we became interested in the observation that impaired renal acidification and hypergammaglobulinemia are related (2). The availability of patients with leprosy afforded an opportunity to evaluate the incidence of renal tubular acidosis in a single disease in which serum gamma globulin...References1. TALAL N: Sjögren's syndrome, lymphoproliferation, and renal tubular acidosis. Ann Intern Med 74:633-634, 1971 LinkGoogle Scholar2. MORRISFUDENBERG RH: Impaired renal acidification in patients with hypergammaglobulinemia. Medicine (Baltimore) 46:57-69, 1967 CrossrefMedlineGoogle Scholar3. WRONGDAVIES OH: The excretion of acid in renal disease. Q J Med 28:259-313, 1959 MedlineGoogle Scholar4. RIDLEYJOPLING DW: Classification of leprosy according to immunity; a five-group system. Int J Lepr 34:255-273, 1966 Google Scholar5. TURK J: Immunological processes in infective diseases, in Immunology in Clinical Medicine. New York, Appleton-Century-Crofts, 1969, p. 60 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID J. DRUTZ, M.D.; ROBERT A. GUTMAN, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLEPROSY NEPHROPATHY: A REVIEW OF CLINICAL AND HISTOPATHOLOGICAL FEATURESRenal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular DisordersPathogenesis and Treatment of Immune-mediated Renal DiseaseRenal Complications of Infectious Diseases 1 September 1971Volume 75, Issue 3Page: 475-476KeywordsGlobulinsHypergammaglobulinemiaLeprosyLymphocytesRenal diseases ePublished: 1 December 2008 Issue Published: 1 September 1971 PDF downloadLoading ...
Health research policy in the European Union
Authors: Rodolfo Saracci, J⊘rn Olsen, Albert Hofman
Journal: BMJ (2005)

Drastic revision is needed 

“ H ealth” is the number one theme in the first outline proposal of the European Union's seventh framework programme of research (FP7) for 2007-13.1 Translating this indication into actual “research for the health of Europeans” will require a drastic policy revision with relation to the current (FP6, 2002-6) research programme, which is severely lacking in a population dimension2 and champions “the traditional mix of basic science and biomedicine” that is deemed wholly inadequate to support health systems by the World Health Organization's ministerial summit on health research.3

This revision requires four main changes: in conception, content, procedures, and resources. The programme's conception must incorporate a simple but crucial idea: “From the population to the population.” Research prompted by health problems in a population must provide results that are relevant and applicable in that population. This goes against the common misconception—transparent in the sixth research framework—that a solution to a biological or clinical problem found at, say, the molecular level …
1-131 MIBG Scintigraphy of Neuroectodermal Tumors Comparison Between 1-131 MIBG and ln-111 DTPA-Octreotide
Authors: FILIPPO LAURIERO, GIUSEPPE RUBINI, FRANCESCA D??ADDABBO, DOMENICO RUBINI, FRANCESCO SCHETTINI, ANGELO D??ADDABBO
Journal: Clinical Nuclear Medicine (1995)

An account is given of the results observed with 1-131 MIBG scintigraphy in four patients (1 bladder pheochromocytoma, 3 neuroblastomas) chosen on account of their particular clinical and diagnostic interest from a series of 41 apudoma patients examined by means of this technique. In the first patient, the unusual site of the tumor in the posterior wall of the bladder meant that its detection by 1-131 MIBG was only possible after catheterizatlon of the bladder. In the second patient, uptake in the metastasis was only evident after removal of the primary tumor. In the third patient, the scintiscan revealed several metastases (some in bone) not detected by CT. In the fourth patient (congenital neuroblastoma), enhanced uptake accompanied the appearance of high plasma catecholamlne and urinary vanillylhandelic acid values, suggesting a functional switch from a nonsecret- Ing to a secreting form. A supplementary ln-111 DTPAOctreotide (OCT) scintiscan of this patient demonstrated the presence of somatostatln receptors on the neuroblasts. Thus, this examination would seem particularly useful for the differentiation of nonsecretlng neuroblastomas. Its employment in assessment of the therapeutic capacity of OCT itself is also suggested.
Cytotoxic mechanisms in different forms of T‐cell‐mediated drug allergies
Authors: P C Kuechler, M Britschgi, S Schmid, Y Hari, B Grabscheid, W J Pichler
Journal: Allergy (2004)

Cytotoxic mechanisms are involved in different forms of drug induced exanthems.Here we compare the killing pathways of CD4+, CD8+ and CD4/CD8+ T-cell lines (TCL) and clones derived from patients suffering from maculopapular, bullous and pustular drug eruptions. In vitro, perforin and Fas-mediated killing was analysed in cytotoxicity assays against autologous Epstein-Barr virus (EBV)-transformed B-cell lines, Fas-transfected mouse lymphoblasts and natural killer (NK)-target cells. In addition, affected skin lesions and the TCL and clones were stained for perforin and FasL-expression.We detected perforin and some FasL-mediated killing in all three types of exanthems. Some of the drug-specific T-cell clones analysed exerted mainly perforin-, other more FasL-mediated killing showing no strict relationship between their perforin- and Fas-mediated cytotoxic capacity. Using a cell culture method focusing on the generation of cytotoxic T cells, we detected drug-specific CD8+, TCRalphabeta+ T cells, which failed to proliferate to drug presentation by antigen presenting cells but killed in a drug dependent way. Interestingly, these cells had substantial natural killer-like T cell(s) like features as they were CD56+ and CD94+ and had the ability to kill the NK-sensitive cell line K562.Our data underline the important role of cytotoxic mechanisms in different forms of drug induced exanthems and suggest that even some T cells with NK-like characteristics may be involved in drug hypersensitivity.
Angiotensin Blockade: New Pharmacologic Tools for Understanding and Treating Hypertension
Authors: John H. Laragh
Journal: New England Journal of Medicine (1975)

Traditionally, antihypertensive drug therapy has been empiric because the causes of hypertension could not be identified in most patients and, in consequence, blood-pressure responses to various forms of therapy could not be predicted. Among the new developments that promise to solve these related problems is the use in man of drugs that block either the action1 or the formation2 of the pressor hormone angiotensin II. In the current issue of the Journal, Streeten et al. describe an extensive experience with saralasin, one of these agents. When given parenterally, this octapeptide, which has little pressor activity itself, competes with angiotensin . . .
Epidemiological study of prevalence of chlorpropamide alcohol flushing in insulin dependent diabetics, non-insulin dependent diabetics, and non-diabetics.
Authors: S Ng Tang Fui, H Keen, R J Jarrett, C Strakosch, T Murrells, P Marsden, R Stott
Journal: BMJ (1983)

An epidemiological study was carried out to compare the prevalence of facial flushing in non-diabetics, patients with insulin dependent diabetes, and patients with non-insulin dependent diabetes in response to 40 ml sherry taken 12 hours after 250 mg chlorpropamide or placebo, administered double blind in randomised order. A flush after chlorpropamide but not placebo was reported by 6.2% of non-diabetics (17/273), 9.7% of insulin-dependent diabetics (14/145), and 10.5% of non-insulin dependent diabetics (25/239), excluding those receiving long term chlorpropamide treatment. The differences were not significant. This response was unrelated to age, sex, body mass index, and family history of diabetes in all three groups. Patients taking long term chlorpropamide, however, showed a significantly (p less than 0.01) higher prevalence of flushing after both chlorpropamide and placebo (56.3%; 9/16) compared with the rest of the non-insulin dependent diabetics (16.7%; 40/239), the insulin dependent diabetics (6.9%; 10/145), and the non-diabetics (5.9%; 16/273). Patients receiving long term chlorpropamide would be expected to flush with sherry after a placebo tablet because of therapeutic plasma concentrations of the drug. It is concluded that there is no evidence of an increased prevalence of chlorpropamide alcohol flushing in response to the single challenge test in non-insulin dependent diabetics compared with insulin dependent diabetics and non-diabetics except in selected patients taking chlorpropamide long term. This study does not support the hypothesis that the chlorpropamide alcohol flush is a specific marker for a subtype of non-insulin dependent diabetes.
Problems With Biopsy Needles
Authors: Harold Levine
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The authors of "Pleural Biopsy" (<b>200</b>:317, 1967) correctly identify fragility as a major disadvantage of current, machine-made Cope needles. Because of frequent malfunction of the Cope needles now being produced, comparisons of this instrument to its most obvious present alternative, the Abrams needle, must be precise. The Abrams needle, contrary to the authors' contention, need not be removed with each biopsy specimen. Multiple specimens may be obtained with each insertion of the Abrams needle. This is done by aspirating each specimen into an attached syringe. To achieve this, the Abrams needle is reintroduced into the pleural cavity after the tissue entrapped by the hook has been severed. The cannula is<i>partially</i>opened and pleural fluid is drawn into the syringe, flushing the specimen with it. The cannula is then opened fully and another specimen taken from another quadrant. I regularly obtain four or five specimens with
Doctors and the global population crisis.
Authors: C J Carr
Journal: BMJ (1977)

I read Dr. John A. Loraine's Edward Holme lecture on the global population crisis (September 10, p. 691) with a growing sense of amazement that any man of his standing could be so certain that his views were completely right and those opposed to him so completely wrong. He regrets that when a "liberal" abortion law was introduced in India the number of terminations was "disappointingly small" - he does not seem to consider the possibility that perhaps the Indian people are wiser than he. He condemns the Society for the Unborn Child as "emotive," yet his own views seem dehumanized and amoral. The only surprise is that when he mentions the increasing proportion of elderly people in the population he does not continue to the "logical" conclusion of recommending compulsory euthanasia at a fixed age - perhaps, however, this would be coming too close to home. It was because of the very attitudes that such an article expresses that I, who had been born and educated in Britain, left the country, and I would seriously question whether history will not look back in horror on the "liberal" attitude adopted by the British medical profession, among others, in the 2nd half of the twentieth century.
Problems of care in a private nursing home.
Authors: J Pearson, L Challis, C E Bowman
Journal: BMJ (1990)

To assess problems of care in a private nursing home an observational study was carried out over two months, during which a research nurse worked as a member of the staff in a home caring for 25 patients aged 62-90. During the second month a consultant physician visited the home weekly to hold case conferences and assess each patient's functional ability and drug regimen. Various problems in medical, nursing, and bureaucratic matters were identified--for example, staff failed to understand the appropriate response to various medical symptoms; no clear policy existed for managing pressure sores; and one patient's anticoagulant state could not be assessed when industrial action meant that transport to take him to hospital was not available--and several changes in drug treatments were recommended. The problems that were identified were mainly due to poor communication between the home and general practitioners and hospitals and to the lack of guidance policy on common issues that arise in long term care. Such a policy could be produced by health authority staff, general practitioners, and representatives of nursing homes.
Birth Order and MS
Authors: Joan Stephenson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IFN-γ promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation
Authors: Yanping Yang, Hui Wang, Hui Yu, Beow Yong Yeap, Tingting Liang, Guanjun Wang, Tao Cheng, Yong-Guang Yang
Journal: Blood (2011)
Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems
Authors: Deepa Mohanan, Bram Slütter, Malou Henriksen-Lacey, Wim Jiskoot, Joke A. Bouwstra, Yvonne Perrie, Thomas M. Kündig, Bruno Gander, Pål Johansen
Journal: Journal of Controlled Release (2010)
The Federal Regulation of Prescription Drug Advertising and Promotion
Authors: David A. Kessler
Journal: JAMA (1990)

Prescription drug advertising has been regulated by the Food and Drug Administration since 1962. In the past decade, pharmaceutical companies have employed new communication mechanisms to reach physicians and, with increasing frequency, consumers. Examples of physician-oriented promotional activities are medical symposia and teleconferences. Consumer-oriented efforts include press conferences, use of celebrity spokespeople, and direct-to-consumer advertising. The Food and Drug Administration has asserted its legal jurisdiction over these nontraditional promotional activities and is regulating them on a case-by-case basis. As nontraditional promotional efforts become more prevalent, the Food and Drug Administration's regulatory framework must be able to meet the challenges of a changing environment.Prescription drug advertising in the United States is regulated by the federal Food and Drug Administration (FDA). Kessler and Pines review the FDA's actions under the Food, Drug, and Cosmetic Act in regulating traditional forms of drug advertising. They describe the nontraditional forms of advertising that the pharmaceutical industry has begun to use within the last decade to reach physicians and consumers. On a case-by-case basis, the FDA is asserting its jurisdiction over promotional activities such as industry-sponsored medical symposia and teleconferences, press conferences, celebrity spokespersons, and direct-to-consumer advertising. Kessler and Pines conclude that the FDA's regulatory framework must evolve along with advertising techniques; it should focus on public health issues raised by pharmaceutical advertising and on the content of the information being conveyed.
Comparison of the effects of the ionophore salinomycin and adrenaline on the haemodynamics and work efficiency of the dog heart
Authors: M. FAHIM, G. DEL VALLE, B. C PRESSMAN
Journal: Cardiovascular Research (1986)

Journal Article Comparison of the effects of the ionophore salinomycin and adrenaline on the haemodynamics and work efficiency of the dog heart Get access MOHAMMAD FAHIM, MOHAMMAD FAHIM From the Department of Pharmacology, University of Miami, School of Medicine, Miami, Florida, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar GINA DEL VALLE, GINA DEL VALLE From the Department of Pharmacology, University of Miami, School of Medicine, Miami, Florida, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar BERTON C PRESSMAN BERTON C PRESSMAN From the Department of Pharmacology, University of Miami, School of Medicine, Miami, Florida, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 20, Issue 2, February 1986, Pages 145–152, https://doi.org/10.1093/cvr/20.2.145 Published: 01 February 1986