tbuckley/cabot-search huggingface dataset:
The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1
Authors: Szu-Hua Pan, Yu-Chih Chao, Pei-Fang Hung, Hsuan-Yu Chen, Shuenn-Chen Yang, Yih-Leong Chang, Chen-Tu Wu, Cheng-Chi Chang, Wen-Lung Wang, Wing-Kai Chan, Yi-Ying Wu, Ting-Fang Che, Lu-Kai Wang, Chien-Yu Lin, Yung-Chie Lee, Min-Liang Kuo, Chau-Hwang Lee, Jeremy J.W. Chen, Tse-Ming Hong, Pan-Chyr Yang
Journal: Journal of Clinical Investigation (2011)

Metastasis is a predominant cause of death in patients with cancer. It is a complex multistep process that needs to be better understood if we are to develop new approaches to managing tumor metastasis. Tumor cell invasion of the local stroma is suppressed by collapsin response mediator protein-1 (CRMP-1). Recently, we identified a long isoform of CRMP-1 (LCRMP-1), expression of which correlates with cancer cell invasiveness and poor clinical outcome in patients with non-small-cell lung cancer (NSCLC). Here, we report that LCRMP-1 overexpression in noninvasive human cell lines enhanced filopodia formation, cancer cell migration, and invasion via stabilization of actin. This effect required a highly conserved N-terminal region of LCRMP-1 as well as the WASP family verprolin-homologous protein-1/actin nucleation pathway (WAVE-1/actin nucleation pathway). Furthermore, LCRMP-1 appeared to act downstream of Cdc42, a Rho family protein known to be involved in actin rearrangement. In addition, LCRMP-1 associated with CRMP-1, which downregulated cancer cell metastasis by interrupting the association of LCRMP-1 and WAVE-1. Finally, we found that high-level expression of LCRMP-1 and low-level expression of CRMP-1 were associated with lymph node metastasis and poor survival in patients with NSCLC. In sum, we show that LCRMP-1 and CRMP-1 have opposing functions in regulating cancer cell invasion and metastasis and propose that this pathway may serve as a potential anticancer target.
Survival After Bariatric Surgery Among High-Risk Patients--Reply
Authors: M. L. Maciejewski, E. H. Livingston, D. E. Arterburn
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes.
Authors: J M Watson, E J Jenkins, P Hamilton, M J Lunt, D Kerr
Journal: Diabetes Care (2000)

OBJECTIVE: To examine the influence of caffeine on the frequency and perception of hypoglycemia in "free-living" patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: A total of 34 patients with type 1 diabetes were recruited for a prospective randomized placebo-controlled double-blind study. After a lead-in phase and while adhering to a low-caffeine diet, subjects were randomized to capsules containing either 200 mg caffeine or matched placebo with crossover at 3 months. Hypoglycemic episodes were monitored throughout with capillary blood glucose readings and a symptom questionnaire. During the study, measurements of blood pressure, middle cerebral artery blood velocity (a surrogate measure of cerebral blood flow), cognitive function (via a four-choice reaction time test), HbAlc levels, and lipid profiles were taken at the beginning and end of each phase. RESULTS: Throughout the study, no changes were evident regarding glycemic control or lipid profile. The number of symptomatic episodes was greater with caffeine (1.3 vs. 0.9 episodes/week; P &amp;lt; 0.03) and was associated with more intense warning symptoms (29 vs. 26 total symptom score; P &amp;lt; 0.05). For women, caffeine ingestion caused a modest pressor response (115 vs. 110 mmHg; P &amp;lt; 0.01). Four-choice reaction time improved slightly with caffeine supplementation (P &amp;lt; 0.05). CONCLUSIONS: Ingestion of modest amounts of caffeine enhances the intensity of hypoglycemia warning symptoms in patients with type 1 diabetes without altering the prevailing standard of glycemic control or increasing the incidence of severe hypoglycemic episodes.
Please don't touch me there: the ethics of intimate examinations: Summary of rapid responses
Authors: A. Tonks
Journal: BMJ (2003)

EDITOR—The 46 rapid responses to this article included four from patients, four from medical students, and 30 from practising doctors.1

The issue of intimate examinations without consent attracted the most powerful comment. Almost all those who mentioned it said that it was unethical and must stop. Some were incredulous, others disappointed that so little progress had been made since this issue first surfaced in the early 1980s. Two (a patient and a solicitor) said it was, or should be, a criminal offence.

No one could explain why it endured. And only a handful tried to defend it. One, a junior surgeon, wrote: “The gynaecology consultant urging medical students to examine a patient while under anaesthetic, …
COMPARATIVE EFFECTIVENESS OF RADIAL AND FEMORAL APPROACHES TO PERCUTANEOUS CORONARY INTERVENTION ON LONG-TERM OUTCOMES: A REPORT FROM THE NHLBI DYNAMIC REGISTRY
Authors: Sunil V. Rao, Faith Selzer, Eric D. Peterson, Suresh R. Mulukutla, Joon S. Lee, Howard A. Cohen, David O. Williams, Alice K. Jacobs, Sheryl F. Kelsey, Oscar C. Marroquin
Journal: Journal of the American College of Cardiology (2010)
The hemodynamic effect of verapamil on portal hypertension in patients with postnecrotic cirrhosis
Authors: Chi-Woon Kong, Chii-Shyan Lay, Yang-Te Tsai, Ching-Lan Yeh, Kwok-Hung Lai, Shou-Dong Lee, Kwang-Juei Lo, Benjamin N. Chiang
Journal: Hepatology (1986)

Wedged hepatic venous pressure, free hepatic venous pressure and cardiac index were measured before and 1 hr after i.v. administration as well as 1 month and 3 months after chronic oral administration of verapamil in 10 patients with HBsAg-positive cirrhosis. The gradient between wedged hepatic venous pressure and free hepatic venous pressure was decreased 14% at 1 hr after i.v. administration of 10 mg verapamil, and the sustained decrease in hepatic venous pressure gradient was also demonstrated in the patients after 1 month, and in six patients after 3 months of continuous oral administration of verapamil. The mean arterial pressure significantly decreased (p&lt;0.01) 1 hr after the administration of verapamil. There was no significant change in other hemodynamic values. We conclude that chronic oral administration of verapamil can reduce the hepatic venous pressure gradient in patients with compensated HBsAg-positive cirrhosis and portal hypertension.
Chromosomal Translocation Involving the Immunoglobulin Kappa-Chain and Heavy-Chain Loci in a Child with Chronic Lymphocytic Leukemia
Authors: Joseph A. Sonnier, George R. Buchanan, Patricia N. Howard-Peebles, Joe Rutledge, R. Graham Smith
Journal: New England Journal of Medicine (1983)

Chronic lymphocytic leukemia is usually a monoclonal B-cell neoplasm that occurs almost exclusively in middle-aged and elderly adults. We observed a rapidly progressive case of the disease in a 10-year-old girl. The leukemic cells bore surface IgM and IgD immunoglobulins of the kappa-light-chain type. Karyotyping of the abnormal cells revealed an unusual translocation [t(2;14) (p13;q32)], with break points at or near the kappa-light-chain and heavy-chain gene loci. Translocations involving the immunoglobulin gene loci may be important in the pathogenesis of some cases of chronic lymphocytic leukemia, as they appear to be in Burkitt's lymphoma.
BMA's annual meeting expresses "no confidence" in GMC
Authors: L. Beecham
Journal: BMJ (2000)

Doctors at the BMA's annual representative meeting overwhelmingly declared their lack of confidence in the General Medical Council “as presently constituted and functioning.”

Very few of the 450 representatives wanted to abolish the council; the vast majority reaffirmed support for professional self regulation and for the principle of revalidation, although there was criticism of the GMC's revalidation proposals.

The meeting did, however, want the council to “initiate urgent reform of its structures and functions in consultation with the profession.”

Similar votes of no confidence were passed by the senior and junior hospital staffs conferences and by the public health conference (10 June, p 1557; 17 June, p 1626). The conference of local medical committees called on …
Serum immunoglobulin free light-chain measurement in primary amyloidosis: prognostic value and correlations with clinical features
Authors: Shaji Kumar, Angela Dispenzieri, Jerry A. Katzmann, Dirk R. Larson, Colin L. Colby, Martha Q. Lacy, Suzanne R. Hayman, Francis K. Buadi, Nelson Leung, Steve R. Zeldenrust, Marina Ramirez-Alvarado, Raynell J. Clark, Robert A. Kyle, S. Vincent Rajkumar, Morie A. Gertz
Journal: Blood (2010)
Psychological influences on cancer and ischaemic heart disease.
Authors: A. J. Pelosi, L. Appleby
Journal: BMJ (1992)

to take place in more than one area" and "committees should arrive at a voluntary arrangement under which one LREC is nominated to consider the issue on behalf of all of them."If a tidy administrative solution is sought-and it is questionable whether that should have precedence over local autonomy-it is surprising that no mention is made of the possible role of a national research ethics committee in authorising multicentre studies conducted under the auspices of, for example, the Medical Research Council or Cancer Research Campaign.The guidelines will also produce other frustrations for those planning multicentre studies.Some com- mittees have their own application forms which must be completed and returned together with the protocol under consideration.Inevitably, these forms have not been standardised, with the result that many different forms may be required for the same study.The department should produce standard application forms for all proposed research projects, especially as this would also help maintain the register of proposed research which all ethics committees must now keep.Lack of attention to practical detail is seen through- out the guidelines which, despite an assertion to the contrary in the accompanying circular, also fail to consider ethical principles governing the conduct of research.Perhaps it was never the department's intention to provide such a discussion.For whatever reason, those who serve on committees will have to seek ethical guidance elsewhere.
Survivin Determines Cardiac Function by Controlling Total Cardiomyocyte Number
Authors: Bodo Levkau, Michael Schäfers, Jeremias Wohlschlaeger, Karin von Wnuck Lipinski, Petra Keul, Sven Hermann, Naomasa Kawaguchi, Paulus Kirchhof, Larissa Fabritz, Jörg Stypmann, Lars Stegger, Ulrich Flögel, Jürgen Schrader, Jens W. Fischer, Patrick Hsieh, Yen-Ling Ou, Felix Mehrhof, Klaus Tiemann, Alexander Ghanem, Marek Matus, Joachim Neumann, Gerd Heusch, Kurt W. Schmid, Edward M. Conway, Hideo A. Baba
Journal: Circulation (2008)

Background— Survivin inhibits apoptosis and regulates cell division in many organs, but its function in the heart is unknown. Methods and Results— We show that cardiac-specific deletion of survivin resulted in premature cardiac death. The underlying cause was a dramatic reduction in total cardiomyocyte numbers as determined by a stereological method for quantification of cells per organ. The resulting increased hemodynamic load per cell led to progressive heart failure as assessed by echocardiography, magnetic resonance imaging, positron emission tomography, and invasive catheterization. The reduction in total cardiomyocyte number in α-myosin heavy chain (MHC)–survivin −/− mice was due to an ≈50% lower mitotic rate without increased apoptosis. This occurred at the expense of DNA accumulation because survivin-deficient cardiomyocytes displayed marked DNA polyploidy indicative of consecutive rounds of DNA replication without cell division. Survivin small interfering RNA knockdown in neonatal rat cardiomyocytes also led to polyploidization and cell cycle arrest without apoptosis. Adenoviral overexpression of survivin in cardiomyocytes inhibited doxorubicin-induced apoptosis, induced DNA synthesis, and promoted cell cycle progression. The phenotype of the αMHC-survivin −/− mice also allowed us to determine the minimum cardiomyocyte number sufficient for normal cardiac function. In human cardiomyopathy, survivin was potently induced in the failing heart and downregulated again after hemodynamic support by a left ventricular assist device. Its expression positively correlated with the mean cardiomyocyte DNA content. Conclusions— We suggest that the ontogenetically determined cardiomyocyte number may be an independent factor in the susceptibility to cardiac diseases. Through its profound impact on both cardiomyocyte replication and apoptosis, survivin may emerge as a promising new target for myocardial regeneration.
Decreased caveolin-1 expression in atheroma: Loss of antiproliferative control of vascular smooth muscle cells in human atherosclerosis
Authors: Carsten Schwencke, Alexander Schmeisser, Rolf Wachter, Brigitta Weck, Rainer Marquetant, Michael Kasper, Ruth H. Strasser
Journal: Journal of the American College of Cardiology (2003)
A Method for Noninvasive Determination of Inspiratory Resistance during Proportional Assist Ventilation
Authors: MAGDY YOUNES, JOHN KUN, BRAD MASIOWSKI, KIMBERLY WEBSTER, DANIEL ROBERTS
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Currently available noninvasive methods for measuring inspiratory resistance (Ri) are difficult to implement or interpret during assisted mechanical ventilation on account of the confounding effect of respiratory efforts (Pmus). We propose a simple method consisting of brief reductions in airway pressure (Paw) in the early part of the inflation phase (pulse). Paw, flow (V˙), and volume (V) are measured at the beginning of the pulse (T 0), at the trough of the pulse (Ti) and at a point 0.1 s before T0 (T− 1). Equations of motion of the form [Pmus + Paw = V˙ · K1 + V˙ 2 · K2 + V · E] are generated for the data at the three time points (E = elastance, K1 and K2 are Rohrer's constants). These three equations can be solved for K1 and K2 if it is arranged that the pulse has appropriate configuration and timing, and if it is assumed that Δ Pmus/ Δ t is constant over the brief pulse period. The method was tested in 67 patients ventilated with proportional assist ventilation (PAV). The results were compared with those obtained using the interrupter technique during a period of controlled mechanical ventilation (CMV). Ri, expressed at a standard flow of 1 L · s− 1, was slightly higher during PAV (16.4 ± 4.9 versus 15.5 ± 4.5 cm H2O · L− 1 · s, p < 0.001). The average difference was 0.9 ± 2.0 cm H2O · L− 1 · s, corresponding to 5.4 ± 12.6% of the average of Rcmv and Rpav. The correlation coefficient was 0.92 (p = 8E − 28) with a slope (1.01) and intercept (0.8) not significantly different from 1.0 and 0, respectively. We conclude that brief negative pulses applied early during the inflation phase can be used to provide reliable estimates of inspiratory resistance during PAV.
Social Security Numbers and Privacy — New Hospital Policy
Authors: William J. Curran
Journal: New England Journal of Medicine (1974)

THE battle still rages over whether the ubiquitous Social Security numbers should be used as a universal personal identification for all Americans. Many data-system planners continue to advocate its use. Here in Massachusetts, as in many states, it is on the automobile driver's licenses along with his picture. Should it be used in hospitals? Those who argue against that use generally make an argument for privacy that so often seems to be defeated by the obvious lack of privacy in its required use by all employers for Social Security payments and by the general "benefit" said to be accruing through . . .
The High Cost of Lost Opportunities for Prevention-Reply
Authors: Hai-Yen Sung
Journal: JAMA (1997)

<h3>In Reply.</h3> —As indicated by Dr Havas, significant savings can be gained through primary prevention of chronic disease. While it seemed implicit to us, the message of prevention always bears reinforcing. In addition, it is important to recognize another large source of potential savings—both in dollars and human suffering—from the prevention of secondary conditions. Secondary conditions are diseases, impairments, functional limitations, or additional disabilities that are caused by (ie, occur as a result of) another condition.<sup>1</sup>Crucially important to preventing these sequelae is a health care system that ensures continuity of care, access to assistive technology and resources, and health education—fundamental elements that enable individuals to manage their own health care effectively and prevent further illness and disability. It was our hope that, by measuring the total prevalence and costs of chronic conditions as a whole, the need for both primary prevention of chronic conditions and the secondary prevention of disability
Abstract A22: Mechanisms of oncogenic cooperation between EGFR/Ras and Hippo pathways in <i>Drosophila</i> and human cellular transformation models
Authors: Xin Hong, Stephen Michael Cohen
Journal: Cancer Research (2013)

Abstract The hippo/Salvador kinase cascade is a highly conserved signaling pathway regulating growth and organ size from Drosophila to mammals. The invertebrate-specific microRNA, bantam, is a key target and effector downstream of the Drosophila hippo pathway. Bantam inhibits the pro-apoptotic factor hid and promotes growth through an as yet unidentified mechanism. The EGFR/Ras pathway coordinates growth and patterning in Drosophila. We characterize a molecular circuit involving bantam, socs36E and EGFR that regulates tissue growth. Socs36E is a direct bantam target that negatively regulates wing size. Socs36E buffers EGFR activity by acting in a negative feedback loop with EGFR. Interestingly, bantam and socs36E repress each other forming a potential bistable switch. This switch might allow effective repression of socs36E during the rapid growth phase of wing disc development. Therefore, bantam represents a unique molecular linkage connecting hippo and EGFR signaling in promoting growth. Furthermore, we found that the mammalian socs family members SOCS5 and SOCS6 are targeted by an oncogenic miRNA, which plays a role in RasV12 mediated tumoriogenesis in soft agar assays. Therefore, the SOCS family proteins are evolutionarily conserved regulators of growth and cancer transformation. Citation Format: Xin Hong, Stephen Michael Cohen. Mechanisms of oncogenic cooperation between EGFR/Ras and Hippo pathways in Drosophila and human cellular transformation models. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr A22.
ST. MARY'S HOSPITAL: CASES OF NERVE-DISORDER, RECORDED WITH REFERENCE TO THE PROBABLE OPERATION OF MALARIA AS A CAUSE
Authors: C. H. Jones
Journal: BMJ (1856)

THE statements with which I would preface the following cases are-(1) that disorders resembling very closely those produced by undoubted malaria are by no means unfre- quent among us; (2) that the modifications they present are not more than might be expected from the diminished intensity of the cause; (3) that the treatment these disor- ders require, medical and hygienic, is the same as is bene- ficial in malarious; (4) that there is room for believing that malaria, though not of an intense kind, is generated in and around London; (5) that paralysis of the sympathetic, when general, is largely concerned in producing the phe- nomena of fever, and, when local, may produce hypersemia, inflammation, hmmorrhage, or secretion-fluxes; (6) that the action of malaria on the nervous system, both cerebro-spinal and sympathetic, is mainly of a debilitating or paralysing nature; often, however, also, in the first in- stance, causing morbid irritation or excitement.CASE I. J. P., male, aged 3 years, admitted December 19th, 1855, residing in Carlisle Place, Marylebone, a small street, or rather cul-de-sac, represented by medical au- thority as one of the most unhealthy ones in the vicinity.Looks tolerably well, but rather pale.Has been ailing since August 1854.Lives on ground floor, in a very damp house.For last month has suffered from attacks of pain in the abdomen, about the middle; the belly "1 gets very hard and drawn in; he seems as if he would choke, and gets black in the face."At the same time, his heart beats very much, and copious perspirations break out.During the attacks, he is bowed forward, and seems to have pain in the back.The attacks come on regularly about seven in
Fatal<i>Clostridium sordellii</i>Infections after Medical Abortions
Authors: Elissa Meites, Suzanne Zane, Carolyn Gould
Journal: New England Journal of Medicine (2010)

intravenous zanamivir therapy was reinitiated.In addition to influenza virus, cytomegalovirus DNA was detected in the blood (for which ganciclovir was administered), and rhinovirus was detected in respiratory specimens.Unfortunately, the patient's clinical situation worsened.The acute respiratory distress syndrome developed, and he ultimately died.Because influenza virus persisted, further resistance analyses were performed retrospectively.Sequencing of the neuraminidase gene of a virus isolated on January 4 revealed a novel isoleucine-to-arginine amino acid substitution at residue 223 (I223R).This residue has been linked to oseltamivir resistance for another influenza subtype (H3N2). 4Subsequent in vitro phenotypic testing of the virus showed that the 50% inhibitory concentration for the drugs taken by this patient (oseltamivir and zanamivir) was increased by a factor of 45 and 10, respectively.Moreover, when we tested the sensitivity to peramivir, a novel neuraminidase inhibitor in clinical development, we observed an increase in the 50% inhibitory concentration by a factor of seven.The absence of an adequate immune response and possibly suboptimal drug levels may have contributed to the emergence of the I223R mutant.Further research is warranted to determine the clinical and epidemiologic consequences of mutants with reduced sensitivity to neuraminidase inhibitors, since they leave physicians with limited treatment options.