tbuckley/cabot-search huggingface dataset:
Abstract 12446: Impact of Soluble LR11 on Target Lesion Revascularization After Coronary Intervention in Patients with Stable Coronary Artery Disease
Authors: Manabu Ogita, Katsumi Miyauchi, Tomotaka Dohi, Tadashi Miyazaki, Naohisa Nakajima, Takayuki Yokoyama, Takahiko Kojima, Ken Yokoyama, Takeshi Kurata, Hideaki Bujyo, Hiroyuki Daida
Journal: Circulation (2010)

Background:  LR11, an LDL receptor family member, is a novel marker of intimal smooth muscle cells (SMC). The circulating LR11 likely reflect the pathophysiological condition of intimal SMCs, and is a novel marker of intimal SMCs proliferation. However, it has remained uncertain that LR11 predict restenosis after coronary intervention as a results of proliferation of SMC. We evaluated LR11 as a predicitor of target lesion revascularization (TLR) after coronary stenting in patients with coronary artery disease (CAD).   Methods:  Two hundred nine consecutive SAP patients (mean age 67.0±9.4 years, male 81.8%) treated with PCI who had follow-up coronary angiography were enrolled in this study. Clinical and angiographic data including serum sLR11 were obtained at baseline and follow-up (mean follow-up period 235±48 days). The DES use was 82% of all subjects. Overall, serum sLR11 at follow-up was significantly lower in TLR patients than that in TLR subjects (8.10±2.31 vs 9.35±3.30, p=0.047) though there was no significant difference at baseline characteristics.Multivariate logistic regression analyses were performed to identify the clinical and angiographic predictors of TLR. Percent change in sLR11 (10% change, odds ratio (OR) 1.28, 95% confidence interval (CI) 1.01–1.63, p=0.043) was a significant predictor of TLR.   Conclusion:  Our results demonstrated that sLR11 might have an impact on the TLR in patients with stable CAD following coronary intervention. Futher study needed to elucidate the mechanism of how sLR11 plays a role in local reaction after coronary stenting
Adult lipophagic atrophic panniculitis
Authors: I. J. UMBERT, R. K. WINKELMANN
Journal: British Journal of Dermatology (1991)

We report two patients with chronic, recurrent, nodular panniculitis lesions that later developed areas of lipoatrophy. Histologically, there was a consistent lobular lipophagic replacement of fat cells with lipophagic giant cells. The clinical appearance was that of tender, erythematosus, superficial or subcutaneous, symmetrical nodules and plaques of 1–2 weeks' duration. The lesions could occur with episodes of fever. One patient had hepatomegaly and the other had an increased sedimentation rate and leucocytosis. The histology and the clinical pattern of the panniculitus syndrome resembled those of lipophagic lipoatrophy of childhood. This is a panniculitis of unknown cause in which the principal inflammatory cell response in the subcutaneous tissue is the macrophage.
Prenatal Exposure to Wartime Famine and Development of Antisocial Personality Disorder in Early Adulthood
Authors: Richard Neugebauer
Journal: JAMA (1999)

Several observational epidemiological studies report an association of pregnancy and obstetric complications with development of antisocial personality disorder (ASPD) in offspring. However, the precise nature and timing of the hypothesized biological insults are not known.To test whether severe maternal nutritional deficiency early in gestation is associated with risk for ASPD in offspring.Retrospective cohort study. From October 1944 to May 1945, the German army blockaded food supplies to the Netherlands, subjecting the western Netherlands first to moderate (official food rations, 4200-6300 kJ/d) then to severe (<4200 kJ/d) nutritional deficiency. The north and south were subjected to moderate nutritional deficiency only.Dutch men born in large urban areas in 1944-1946 who were given psychiatric examinations for military induction at age 18 years (N = 100543) were classified by the degree and timing of their prenatal exposure to nutritional deficiency based on their birthdate and birthplace.Diagnosis of ASPD by psychiatric interview at time of medical examination for military induction, using the International Classification of Diseases, Sixth Revision (ICD-6).Men exposed prenatally to severe maternal nutritional deficiency during the first and/or second trimesters of pregnancy exhibited increased risk for ASPD (adjusted odds ratio [OR], 2.5; 95% confidence interval [CI], 1.5-4.2). Third-trimester exposure to severe nutritional deficiency and prenatal exposure to moderate nutritional deficiency were not associated with risk for ASPD.Our data suggest that severe nutritional insults to the developing brain in utero may be capable of increasing the risk for antisocial behaviors in offspring. The possible implications of these findings for both developed countries and developing countries, where severe nutritional deficiency is widespread and often exacerbated by war, natural disaster, and forced migration, warrant study.
The Osseous System in the Insane
Authors: J. F. Briscoe
Journal: BMJ (1898)

THE INSANE.[TM 3JW ¶m I677At present our elder patient is taking a preparation of pituitary gland.The younger is on arsenic, which we propose to push.I am bound to say that though I hope for perma- nent benefit from these measures, I am very far from expect- ing it.
Abstract P5-03-09: Ovarian Hormones Promote Mammary Carcinogenesis by Altering Growth Factor Receptor Signaling
Authors: A Arumugam, J Parada, M Gamez, T Boopalan, A Delgado, P Agullo, R. Lakshmanaswamy
Journal: Cancer Research (2010)

Abstract Study of carcinogenesis in rat models plays an important role in understanding the nature of neoplastic transformation. Identification of biological, cellular and molecular alterations involved in the carcinogen induced preneoplastic transformation has vital importance in mammary cancer development. Copenhagen rats are resistant to the carcinogen, N-methyl-N-nitrosourea (MNU) induced mammary carcinogenesis. Our previous studies indicate that MNU induced preneoplastic lesions were promoted to mammary cancer by the hormones estrogen and progesterone. The purpose of this study is to delineate the molecular mechanisms of hormonal promotion of mammary carcinogenesis. Seven week old female Copenhagen rats were administered a single dose of 50 mg/kg body weight MNU intraperitoneally. Four weeks post carcinogen administration, rats were divided into 4 groups, 1) Control, 2) rats treated with 30 mg estradiol, 3) rats treated with 30 mg progesterone, 4) rats treated with 30 mg estradiol plus 30 mg of progesterone. Two weeks after the implantation rats were killed and mammary glands were excised and used for further experiments. Quantitative RT-PCR experiments showed up-regulation of growth factor receptors such as Igf-1r, Egfr and growth factor signaling members Grb2, Pi3k and Ras mRNA expression. Immuno histochemical studies showed strong staining to growth factor receptors and western blotting studies showed increased protein levels of growth factor receptors such as IGF-1R and EGFR and active form of proliferative signaling molecules Akt and SAPK/JNK were up-regulated in combination of estradiol and progesterone treated rats. Phosphorylated p38 was reduced in the combination of hormones treated rat preneoplastic lesions when compared to control. Combination of ovarian hormones treatment provided enhanced growth factor signaling environment and promoted the mammary lesions through activation of SAPK/JNK and growth factor signaling pathways. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P5-03-09.
Treatment of Scarlatina Maligna
Authors: G. Weekes
Journal: BMJ (1843)

M. Raciborski read a memoir on this subject.His conclusions were drawn from seven cases of women who continued to menstruate during the whole or greater part of the period of suckling; they are- 1.That, contrary to the generally received opinion, the milk of nurses who menstruate during the period of suckling does not differ in any appreciable manner from that of nurses who do not menstruate.2. The only difference, worth noting, is that it contains less cream-a fact on which the blueish color of the milk from some women depends.3. That the inconveniences of allowing a woman to -nurse during menstruation has been greatly exagge- rated, and that a nurse should never be rejected on this account alone.
Treatment of a Psychotic Family in a Family Psychiatry Setting
Authors: E. Chandler, H.M. Holden, M. Robinson
Journal: Psychotherapy and Psychosomatics (1968)

Research Articles| February 12 2010 Treatment of a Psychotic Family in a Family Psychiatry Setting Subject Area: Psychiatry and Psychology E. Chandler; E. Chandler London Search for other works by this author on: This Site PubMed Google Scholar H.M. Holden; H.M. Holden London Search for other works by this author on: This Site PubMed Google Scholar M. Robinson M. Robinson London Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1968) 16 (6): 339–347. https://doi.org/10.1159/000285965 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation E. Chandler, H.M. Holden, M. Robinson; Treatment of a Psychotic Family in a Family Psychiatry Setting. Psychother Psychosom 1 June 1968; 16 (6): 339–347. https://doi.org/10.1159/000285965 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1968Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
GSK hid heart risks of diabetes drug, claims Senate committee
Authors: J. H. Tanne
Journal: BMJ (2010)

The US Senate’s Finance Committee has claimed that GlaxoSmithKline (GSK) knew that “there were possible cardiac risks associated with Avandia” (rosiglitazone) for several years before a 2007 study in the New England Journal of Medicine showed a link between the drug and heart attacks.

The committee released a 342 page report on Saturday 20 February. It said the company should have warned patients and the Food and Drug Administration. “Instead,” the report says, “GSK executives attempted to intimidate independent physicians, focused on strategies to minimize or misrepresent findings that Avandia may increase cardiovascular risk, and sought ways to downplay findings that a competing drug might reduce cardiovascular risk.” It says that another drug, pioglitazone (Actos), might pose less risk to patients.

Rosiglitazone, a thiazolidinedione, is used to treat type 2 diabetes. It helps control blood sugar concentrations by increasing sensitivity to insulin. It is marketed in the United …
SPOROTRTCHOSIS IN EGYPT.
Authors: ABDEL MONEM EL-MOFTY, MOHAMED NADA
Journal: British Journal of Dermatology (1965)

Journal Article SPOROTRTCHOSIS IN EGYPT. Get access ABDEL MONEM EL‐MOFTY, ABDEL MONEM EL‐MOFTY Professor of Dermatology Search for other works by this author on: Oxford Academic Google Scholar MOHAMED NADA MOHAMED NADA Clinical Demonstrator, Department of Dermatology, Faculty of Medicine, Cairo University Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 7, 1 July 1965, Pages 357–364, https://doi.org/10.1111/j.1365-2133.1965.tb14661.x Published: 01 July 1965
What is the clinical relevance of portal hypertensive gastropathy (PHG) in patients with compensated liver cirrhosis?
Authors: F. Schepis, C. Cammà, D. Niceforo, A. Magnano, S. Pallio, M. Cinquegrani, A. Craxì, A. Saitta, G. Raimondo
Journal: Journal of Hepatology (2001)
A different perspective
Authors: Liam Farell
Journal: BMJ (2007)

We have peace now in Northern Ireland, which is a good thing—although it's ironic that the deal could have been done 30 years and thousands of lives ago and was originally scuppered by the very people now in power. There is an unpleasant lesson here: in any negotiation, you need the extremists on board. They're the ones who can make the deal stick, as no one can accuse them of selling out without losing, for example, their thumbs.

I was aware …
Chylothorax after closure of a patent ductus arteriosus.
Authors: M S Gotsman
Journal: Thorax (1966)

From the Children's Hospital, Birmingham Traumatic chylothorax has occurred after nearly every intrathoracic operation (Ross, 1961;Williams and Burford, 1964).If malignant disease and its operations are excluded, it is most common after splanchnicectomy (Hodge and Bridges, 1948), resection of coarctation of the aorta, and Blalock's anastomosis (Shumacker and Moore, 1951 ; Baffes and Potts, 1954).It is uncommon after ligation or transection of the ductus arteriosus, and few cases have been reported in the literature (Baffes and Potts, 1954; Vandecasteele and Soots, 1961).We have observed traumatic chylothorax after transection of a persistently patent ductus arterio- sus and will describe the favourable outcome with conservative management. CASE REPORTC. T. is an only child.A murmur was detected three weeks after birth.She had two serious episodes of acute bronchitis at the age of 10 and 12 months respectively.Apart from failure to thrive she was symptom-free.At the age of 16 months she weighed 14 lb.(6 35 kg.) and was 271 in. (70cm.) in height.a smaller volume was removed on each occasion.At each aspiration all the chyle was removed, since 129
Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model
Authors: Johnnie J. Orozco, Tom Bäck, Aimee Kenoyer, Ethan R. Balkin, Donald K. Hamlin, D. Scott Wilbur, Darrell R. Fisher, Shani L. Frayo, Mark D. Hylarides, Damian J. Green, Ajay K. Gopal, Oliver W. Press, John M. Pagel
Journal: Blood (2013)
Respiratory muscle weakness in Addison's disease.
Authors: A. Mier, C. Laroche, J. Wass, M. Green
Journal: BMJ (1988)

Thyroid antibodies in patients before and during long term amiodarone treatment No of days of treatment with Positive thyroid antibodies* amiodarone Before During n amiodarone amiodarone Mean (SD) Range Pisa and Cagliari: Short term (--three months) 19 1 1 41(26) 13-98 Long term (-four months) 12 1 2t
The nature of economical coding is determined by the unique properties of objects in the environment
Authors: Stephen Handel
Journal: Behavioral and Brain Sciences (2008)

Abstract The physical properties that signify objects differ dramatically, so that the organization of sensory systems must reflect those differences. Although all senses may encode peripheral sensory information using across-fiber firing distributions, an economical coding system for each sense will necessarily differ. An economical code must maximize information about objects, whether they are predators or foods.
Seventh International Congress of Hygiene and Demograghy.
Authors: John S. Billings
Journal: JAMA (1890)

<h3>To the Editor:</h3> —I am requested by the Honorary Secretaries of the Committee of Organization of the Seventh International Congress of Hygiene and Demography, to call attention to the fact that this Congress will be held in London during the week beginning August 10, 1891. The Governments of all countries, and municipalities, and all public health authorities, universities, colleges and societies occupied in the study of the sciences more or less immediately connected with hygiene, are invited to coöperate and appoint delegates to represent them at the Congress. The Prince of Wales will preside. A Committee of Organization has been formed of which Sir Douglas Galton is Chairman, and Prof. W. H. Corfield and Mr. Shirley F. Murphy are Honorary Secretaries. An exhibition of articles of hygienic interest will be held in connection with the Congress. The last of these Congresses was held in Vienna in 1887, and was attended
Abstract 3982: Immuno-sensitization of malignant gliomas by natural polyphenols.
Authors: Chandramouli Mandalaparty, Andrew Huang, Sandeep Mittal, Agnes M. Rimando, Q. Ping Dou, Prahlad Parajuli
Journal: Cancer Research (2013)

Abstract Malignant gliomas are the most common primary brain tumors with approximately 22,000 cases per year. In spite of aggressive surgery, radiotherapy and chemotherapeutic regimens, the median survival of patients with malignant gliomas is a dismal 15 months. The objective of our study was to explore the adjuvant therapeutic potential and associated molecular mechanisms of natural polyphenols stilbenes in malignant gliomas. Recent studies have demonstrated the efficacy of stilbenes in extracranial tumor models. Stilbenes, including resveratrol, were bioavailable in the brain even after low dose oral administration and there was no toxicity to normal tissue. On the contrary, these compounds were found to be neuroprotective in Alzheimer's disease models. Mechanistically, stilbenes modulate NF-κB, STAT3, wnt/β-catenin signaling and also inhibits antiapoptotic protein Bcl-xl. While these molecules are critical in imparting chemoresistance, they are also pivotal in inducing immune-resistance and pro-tumor immune infiltration in gliomas. We hypothesized that stilbenes enhance the efficacy of chemotherapy while also inhibiting immune-suppression and -resistance in malignant gliomas via overlapping molecular mechanisms. We observed significant positive interaction between Temozolomide and Resveratrol for inhibition of glioma proliferation. Resveratrol induced apoptosis in gliomas via inhibition of Bcl-2 and Bcl-xl, while STAT3 activity was also inhibited. Importantly, Resveratrol significantly enhanced the expression of TRAIL-R2 and MIC A/B in gliomas, making them vulnerable to lysis by CTLs and NK cells. Studies are underway to determine combined effect of DC-based immunotherapy and stilbenes against malignant gliomas using syngeneic, orthotopic mouse glioma models. The results can have significant impact in developing novel adjuvant studies to improve survival in patients with malignant gliomas. Citation Format: Chandramouli Mandalaparty, Andrew Huang, Sandeep Mittal, Agnes M. Rimando, Q. Ping Dou, Prahlad Parajuli. Immuno-sensitization of malignant gliomas by natural polyphenols. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3982. doi:10.1158/1538-7445.AM2013-3982
Association of Mouse <i>Dlg4</i> (PSD-95) Gene Deletion and Human <i>DLG4</i> Gene Variation With Phenotypes Relevant to Autism Spectrum Disorders and Williams' Syndrome
Authors: Michael Feyder, Rose-Marie Karlsson, Poonam Mathur, Matthew Lyman, Roland Bock, Reza Momenan, Jeeva Munasinghe, Maria Luisa Scattoni, Jessica Ihne, Marguerite Camp, Carolyn Graybeal, Douglas Strathdee, Alison Begg, Veronica A. Alvarez, Peter Kirsch, Marcella Rietschel, Sven Cichon, Henrik Walter, Andreas Meyer-Lindenberg, Seth G.N. Grant, Andrew Holmes
Journal: American Journal of Psychiatry (2010)

Objective: Research is increasingly linking autism spectrum disorders and other neurodevelopmental disorders to synaptic abnormalities ("synaptopathies"). PSD-95 (postsynaptic density-95, DLG4) orchestrates protein-protein interactions at excitatory synapses and is a major functional bridge interconnecting a neurexinneuroligin-SHANK pathway implicated in autism spectrum disorders. Method: The authors characterized behavioral, dendritic, and molecular phenotypic abnormalities relevant to autism spectrum disorders in mice with PSD-95 deletion (Dlg4−/−). The data from mice led to the identification of single-nucleotide polymorphisms (SNPs) in human DLG4 and the examination of associations between these variants and neural signatures of Williams' syndrome in a normal population, using functional and structural neuroimaging. Results: Dlg4−/− showed increased repetitive behaviors, abnormal communication and social behaviors, impaired motor coordination, and increased stress reactivity and anxiety-related responses. Dlg4−/− had subtle dysmorphology of amygdala dendritic spines and altered forebrain expression of various synaptic genes, including Cyln2, which regulates cytoskeletal dynamics and is a candidate gene for Williams' syndrome. A signifi-cant association was observed between variations in two human DLG4 SNPs and reduced intraparietal sulcus volume and abnormal cortico-amygdala coupling, both of which characterize Williams' syndrome. Conclusions: These findings demonstrate that DLG4 gene disruption in mice produces a complex range of behavioral and molecular abnormalities relevant to autism spectrum disorders and Williams' syndrome. The study provides an initial link between human DLG4 gene variation and key neural endophenotypes of Williams' syndrome and perhaps corticoamygdala regulation of emotional and social processes more generally.
Health and the election
Authors: E. Davies
Journal: BMJ (2012)

With election season now entering the home straight, healthcare has, unsurprisingly, featured heavily in the campaigns of both US presidential candidates.

In their final televised debate last week, Mitt Romney even managed to shoehorn his pledge to repeal “Obamacare” into an exchange about military spending (doi:10.1136/bmj.e7198), saying he would get it …