tbuckley/cabot-search huggingface dataset:
Occupational asthma caused by exposure to asparagus: detection of allergens by immunoblotting
Authors: A. Lopez‐Rubio, J. Rodriguez, J. F. Crespo, R. Vives, P. Daroca, M. Reaño
Journal: Allergy (1998)

Background Vegetables of the Liliaceae family, such as garlic or onion, have been reported to cause occupational asthma. However, there are few data on adverse reactions to asparagus. We evaluated the role of asparagus as a cause of asthma in a patient with respiratory symptoms occurring at work (horticulture) and studied relevant allergens. Methods A 28‐year‐oId man complained of rhinoconjunctivitis and asthma when harvesting asparagus at work. Eating cooked asparagus did not provoke symptoms. A positive skin test reaction was observed with raw asparagus, Aiternaria atternata. and grass‐pollen extracts. The methacholine test demonstrated mild bronchial hyperresponsiveness. The patient had an immediate asthmatic response after challenge with raw asparagus extract. Bronchial provocation tests with boiled asparagus, A. aiternata. and control extracts were negative. Two unexposed subjects with seasonal allergic asthma did not react to the raw asparagus extract. Results The double‐blind, placebo‐controlled food challenge with raw asparagus was negative. Serum asparagus‐specific IgE was 13.9 kUA/1. By SDS‐PAGE immunoblot, at least six IgE‐binding components, ranging from 22 to 73 kDa, were detected only in raw asparagus. Concltisions We report a case of occupational asthma caused by asparagus inhalation, confirmed by specific bronchoprovocation. Immunoblot analysis showed that asparagus allergens are very labile and quite sensitive to heat denaturation.
Assessment of Hostility in the Course of Psychosomatic Treatment of Three Patients with Functional Disorders. Part II
Authors: W. Schüffel, O.W. Schonecke
Journal: Psychotherapy and Psychosomatics (1972)

The effects of a dynamically oriented therapy on three patients with functional complaints were followed up by means of clinical judgement and by means of the repertory grid technique (G. Kelly). Special emphasis was laid upon the assessment of hostile attitudes which the patient connects with self, doctor and an imaginative ideal partner. It was assessed how he relates himself to therapist and ideal partner. Finally clinical judgement and grid results were compared. There is a denial of the existence of hostility in self, doctor, partner at the beginning as well as during treatment. There is a trend towards a reduction of the initial idealization of self and therapist. In the individual case significant changing scores can be demonstrated which correspond to the therapeutical course. Thus the grid may be used for supervision purpose in therapy.
Aortic input impedance and left ventricular energetics in acute isovolumic anaemia
Authors: T. N. S. CLARKE, C. PRYS-ROBERTS, G. BIRO, P. FOEX, M. J. BENNETT
Journal: Cardiovascular Research (1978)

Journal Article Aortic input impedance and left ventricular energetics in acute isovolumic anaemia Get access T. N. S. CLARKE, T. N. S. CLARKE From The Nuffield Department of Anaesthetics, University of Oxford, The Radcliffe Infirmary, Oxford Search for other works by this author on: Oxford Academic PubMed Google Scholar C. PRYS-ROBERTS, C. PRYS-ROBERTS From The Nuffield Department of Anaesthetics, University of Oxford, The Radcliffe Infirmary, Oxford Search for other works by this author on: Oxford Academic PubMed Google Scholar G. BIRO, G. BIRO 1 From The Nuffield Department of Anaesthetics, University of Oxford, The Radcliffe Infirmary, Oxford 1Present address: Department of Physiology, University of Ottawa, Ottawa, Canada. Search for other works by this author on: Oxford Academic PubMed Google Scholar P. FOËX, P. FOËX From The Nuffield Department of Anaesthetics, University of Oxford, The Radcliffe Infirmary, Oxford Search for other works by this author on: Oxford Academic PubMed Google Scholar M. J. BENNETT M. J. BENNETT From The Nuffield Department of Anaesthetics, University of Oxford, The Radcliffe Infirmary, Oxford Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 12, Issue 1, January 1978, Pages 49–55, https://doi.org/10.1093/cvr/12.1.49 Published: 01 January 1978
What about Health Insurance?
Authors: Roger I. Lee
Journal: New England Journal of Medicine (1945)

WORDS may be used to conceal a real meaning, sometimes intentionally and sometimes unintentionally. This is particularly true of those combinations of words that become slogans. This tendency is as old as words themselves, especially if there is a political relation. With the passage of time, a phrase often comes to connote something quite different from the actual meaning of the words. For example, the catch phrase "health insurance" really means quite the reverse; it is insurance to be used when one is sick. Now, the popular connotation of the term is the provision of medical care of some sort, . . .
Inequalities in access to knee joint replacements for people in need
Authors: P F K Yong
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objectives:</b> To quantify the effects of socioeconomic deprivation and rurality on evidence of need for total knee joint replacement and the use of health services, after adjusting for age and sex. <b>Methods:</b> A random stratified sample of 15 000 people aged ⩾65 years taken from central age/sex registers for the geographical areas covered by the previous Sheffield and Wiltshire Health Authorities. A self completion validated questionnaire was then mailed directly to subjects to assess need for knee joint replacement surgery and whether general practice and hospital services were being used. Subjects were followed up for 18 months to evaluate access to surgery. <b>Results:</b> The response rate was 78% after three mailings. In those aged 65 years and over (with and without comorbidity), the proportion with no comorbid factors and in need of knee replacement was 5.1%; the rate of need among subjects without comorbidity was 7.9%. There were inequalities in health and access to health related to age, sex, geography, and deprivation but not rurality. People who were more deprived had greater need. Older and deprived people were less likely to access health services. Only 6.4% of eligible people received knee replacement surgery after 18 months of follow up. <b>Conclusions:</b> There is an important unmet need in older people, with significant age, sex, geographical, and deprivation inequalities in levels of need and access to services. The use of waiting list numbers as a performance indicator is perverse for this procedure. There is urgent need to expand orthopaedic services and training.
Plasma atrial natriuretic factor concentrations in essential and renovascular hypertension.
Authors: P Larochelle, J R Cusson, J Gutkowska, E L Schiffrin, P Hamet, O Kuchel, J Genest, M Cantin
Journal: BMJ (1987)

Plasma atrial natriuretic factor concentrations were measured in 44 patients with mild untreated essential hypertension and 48 normotensive controls. Mean venous plasma atrial natriuretic factor concentrations were 13.2 (SEM 1.5) and 13.0 (1.3) ng/l in the hypertensive patients and controls, respectively. Plasma atrial natriuretic factor concentrations were significantly correlated with age in both groups. Plasma atrial natriuretic factor concentrations were also measured during renal vein catheterisation in a group of 15 hypertensive patients; of these, eight had renovascular hypertension, and in all eight cases plasma atrial natriuretic factor concentrations were increased in the aorta and inferior vena cava. It is concluded that mild essential hypertension is not associated with increased plasma atrial natriuretic factor concentrations, whereas an age related increase in concentrations occurs in hypertensive and normotensive people.
Infectious disease surveillance update
Authors: Nawsheen Boodhun
Journal: The Lancet Infectious Diseases (2013)

15 confirmed cases of hepatitis A and 89 suspected cases have been reported between November, 2012, and April, 2013, in 14 European countries. All patients had subgenotype IB virus and had travelled to Egypt. Symptoms usually begin 2–6 weeks after exposure to the hepatitis A virus and include dark urine, vomiting, and fatigue. The European Commission, WHO, European Centre for Disease Prevention and Control, and the affected countries are cooperating to monitor the outbreak. Vaccination of contacts of patients should be considered in accordance with national guidance, and hepatitis A vaccination recommendations should be highlighted for people travelling to endemic areas.
Adult Thyroid Cancer After Head and Neck Irradiation in Infancy and Childhood
Authors: FRANK O. BECKER
Journal: Annals of Internal Medicine (1975)

We report the surgical-pathologic findings in 15 adults who had had a history of irradiation to the head and neck in childhood. These patients were selected for thyroid surgery because of a "cold" area or areas detected on 99mTc thyroid scan, with or without palpable thyroid abnormalities. Eight of the fifteen patients had thyroid cancer, and 3 had atypical adenomas. We found multiple lesions in 12 patients. Macroscopic and microscopic malignancy in a location different from the cold area or areas occurred in 5 of the 8 cancer patients. In view of these findings, we recommend that adults who received irradiation to the head and neck in childhood and who have been found to have an abnormal thyroid scan or thyroid examination, or both, have a total thyroidectomy.
Emergency stenting to treat neurological complications occurring after carotid endarterectomy
Authors: Angelo Anzuini, Carlo Briguori, Gary S Roubin, Salvatore Rosanio, Flavio Airoldi, Mauro Carlino, Paolo Pagnotta, Carlo Di Mario, Imad Sheiban, Giuseppe Magnani, Antonio Jannello, Germano Melissano, Roberto Chiesa, Antonio Colombo
Journal: Journal of the American College of Cardiology (2001)
Liquiritigenin pharmacokinetics in a rat model of diabetes mellitus induced by streptozotocin: greater formation of glucuronides in the liver, especially M2, due to increased hepatic uridine 5′-diphosphoglucuronic acid level
Authors: Hee E. Kang, Se I. Sohn, Seung R. Baek, Jee W. Lee, Myung G. Lee
Journal: Metabolism (2010)
Communication With the Fatally Ill
Authors: Martin Lipp
Journal: JAMA (1967)

I have yet to meet any clinician who is completely comfortable dealing with dying patients. Most of us are anxious to become more adept in this area, and yet the customary learning sources supply little more than platitudes and generalities. This useful manual by a Duke psychiatrist offers the clinician an orderly and pragmatic approach to the fatally ill. The author's theme seems to be (p 33): "... tact both includes and transcends honesty... Information can be imparted truthfully, yet in a manner and at a tempo geared to the patient's ability to accept." The ten chapters thoughtfully evaluate the variables to be considered in this theme and conclude with a brief, carefullyphrased discussion of euthanasia. The book's weakest chapter is a three-page discussion entitled "The Meaning of Fatal Illness and Death." The strongest ones involve the practical matters of communication with patient and family. The book is quite readable—certainly more
The sociopolitics of contraception
Authors: Elizabeth Rasche González
Journal: JAMA (1980)

There is little question that contraceptives are often tested in developing countries. Contraceptive research is usually associated with the stated political objective of improving economic conditions over the long term in heavily population countries and freeing the female population to do more with their lives than bear children. The critics maintain that new contraceptives are likely to be foisted on an uninformed population against its will, at least when that population is both predominantly poor and nonwhite. C. Wayne Bardin, M.D., vice-president and director of biomedical research at the Population Council in New York reports that any new contraceptive is tested in the 1st country where an Investigational New Drug (IND) permit or its equivalent can be obtained. When a particular contraceptive is expected to be very controversial according to Bardin, a special point is made of obtaining the IND in the United States. Bardin continued to relate that when a contraceptive product is ready to be distributed, final approval is obtained in the country of manufacture. Bardin reports that attempts are made to assure that the contraceptive is tested ethically and that there is no violation of human rights.
FDA approves prostate cancer "vaccine"
Authors: J. H. Tanne
Journal: BMJ (2010)

The US Food and Drug Administration last week approved the first therapeutic “vaccine” against cancer.

Provenge (sipuleucel-T), made by Dendreon, a company in Seattle, Washington, does not prevent cancer. The individualised treatment is designed to induce a patient’s own cells to attack metastatic prostate cancer that is causing few or no symptoms but that no longer responds to hormone therapy.

Trial results show that Provenge extended men’s lives by an average of 4.1 months, …
Patients' Attitudes Toward Screening for Gestational Diabetes Mellitus in the Illawarra Area, Australia
Authors: Rhonda D Griffiths, Dianne V Rodgers, Robert G Moses
Journal: Diabetes Care (1993)

OBJECTIVE To examine the attitudes toward screening of a group of women who have had GDM compared with a group who were screened but did not have GDM. RESEARCH DESIGN AND METHODS We surveyed 90 women with GDM and 100 control women with a postal questionnaire. They were asked to mark on a six-point Likert scale their responses to statements about certain aspects of screening for diabetes in pregnancy. RESULTS No significant differences were found in mean responses between the two groups. The method of screening was found to be convenient (GDM group, 5.02; control group, 4.77). A strong belief that all women should be screened in pregnancy (GDM group, 5.76; control group, 5.66) and a personal desire for screening in any future pregnancy (GDM group, 5.73; control group, 5.62) were expressed. CONCLUSIONS Both groups of women surveyed in this study were extremely positive about the convenience of the screening method used, the need for all women to be screened in pregnancy, and their desire for screening in future pregnancies.
Point-of-Care Ultrasound in Pediatric Clinical Care
Authors: David J. McLario, Adam B. Sivitz
Journal: JAMA Pediatrics (2015)

Point-of-care (POC) ultrasound has been used by a variety of nonradiologist physicians. Recently, POC ultrasound use by pediatricians has received increased attention with the practice of both established and novel applications.To review various uses of ultrasound by pediatricians, discuss challenges and potential pitfalls as pediatric physicians seek to use ultrasound in their practices, and consider various areas of research needs and opportunities.Available English-language publications from 1970 through December 31, 2014.Limited research supports the notion that many POC ultrasound applications practiced by nonradiologist pediatricians can assist in clinical decision making and procedural success. Future challenges include the need for institutions to train and credential large numbers of health care professionals in the use of pediatric POC ultrasound, as well as the necessity of diverse research efforts, including the establishment of pediatric-specific norms, consideration of optimal educational strategies, and inquiry intended to identify best practices for clinical effectiveness and efficiency.Although considerable effort needs to be devoted to the continued development of pediatric POC ultrasound, there is potential for useful application in a variety of clinical and educational settings.
Traffic related air pollutants shorten life expectancy
Authors: A Bhowmik
Journal: Thorax (2003)

▴ Hoek G, Brunekref B, Goldbohm S, et al . Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet2002;360:1203–9. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] This was a study of a random sample of 5000 subjects aged 59–69 years selected from the Netherlands Cohort Study on … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DHoek%26rft.auinit1%253DG.%26rft.volume%253D360%26rft.issue%253D9341%26rft.spage%253D1203%26rft.epage%253D1209%26rft.atitle%253DAssociation%2Bbetween%2Bmortality%2Band%2Bindicators%2Bof%2Btraffic-related%2Bair%2Bpollution%2Bin%2Bthe%2BNetherlands%253A%2Ba%2Bcohort%2Bstudy.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252802%252911280-3%26rft_id%253Dinfo%253Apmid%252F12401246%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(02)11280-3&link_type=DOI [3]: /lookup/external-ref?access_num=12401246&link_type=MED&atom=%2Fthoraxjnl%2F58%2F1%2F57.atom [4]: /lookup/external-ref?access_num=000178708100009&link_type=ISI
Gluten-Sensitive Enteropathy in Patients with Insulin-Dependent Diabetes Mellitus
Authors: Michael J. Rensch
Journal: Annals of Internal Medicine (1996)

To determine the prevalence of celiac disease in a cohort of patients with insulin-dependent diabetes mellitus and to describe the clinical characteristics of patients with coexistent disease.Prospective cohort study.U.S. Army medical center.47 patients with insulin-dependent diabetes mellitus.Antiendomysial antibody testing was used to screen for celiac disease. The diagnosis of celiac disease required histologic evidence of villous atrophy and crypt hyperplasia and a positive antiendomysial antibody test result. In patients identified as having coexistent disease, complete blood counts, multiphasic biochemical testing, D-xylose absorption testing, and bone mineral density estimates were done.3 of 47 patients with insulin-dependent diabetes mellitus (6.4%; 95% CI, 1.4% to 17.5%) had positive antiendomysial antibody test results and small-bowel biopsy specimens consistent with celiac disease. The 95% CI lies entirely above the estimated prevalence of celiac disease expected in the general U.S. population, which ranges from 0.02% to 0.1%. Mean bone mineral densities were 0.8 and 1.1 SD below age-, ethnicity-, and sex-matched controls in each of the 2 antiendomysial antibody-positive patients tested. Small bowel absorption was abnormal in 1 of the 2 patients tested by D-xylose. Anemia and hypoalbuminemia were not detected in any of the patients with coexistent disease. Only 1 of the 3 patients had symptoms of diarrhea. All patients were at or above their ideal body weights.Celiac disease appears to be more common among patients with insulin-dependent diabetes mellitus than in the general U.S. population (p less than 0.001). Two of the three patients with coexistent disease in this study had subclinical or latent celiac disease.
Hyperkalemia and Renin Deficiency
Authors: Norman M Kaplan
Journal: New England Journal of Medicine (1972)

Hyperkalemia can be caused by a deficiency of the salt-retaining hormone, aldosterone. As most readily seen in patients with adrenal insufficiency, the lack of salt-retaining hormone leads to decreased renal tubular reabsorption of sodium. Since potassium is excreted in exchange for sodium reabsorbed, potassium excretion is decreased, resulting in hyperkalemia.The deficiency of aldosterone may be selective. The first report of a patient with isolated aldosterone deficiency clearly defined the typical features of the syndrome: elderly patients with mild to moderate renal insufficiency in whom severe hyperkalemia develops, particularly when they are deprived or depleted of sodium, the hyperkalemia manifested . . .
THE REACTION OF HUMAN BILE AND ITS RELATION TO GALL STONE FORMATION
Authors: John G. Reinhold, L. Kraaer Ferguson
Journal: The Journal of Experimental Medicine (1929)

1. The human gall bladder acidifies the bile. In this respect its action is similar to that of the gall bladders of lower animals, previously described by other workers. 2. The hydrogen ion concentration of gall bladder bile is increased considerably in cases of obstruction of the common or cystic ducts. The highest values were found following complete obstruction. 3. The occurrence of gall stones was not associated with a consistent change in the hydrogen ion concentration of the gall bladder bile.
Prostaglandin E1 vasospastic disease and thermography.
Authors: V Kyle, G Parr, R Salisbury, P.P Thomas, B Hazleman
Journal: Annals of the Rheumatic Diseases (1985)

This is the first study to show a quantitative thermographic difference between patients with Raynaud's syndrome and normal controls after cold stress testing. An improved thermographic response to cold stress testing after treatment of Raynaud's syndrome with PGE1 has also been shown for the first time. Discriminant analysis of the change in temperature of a finger after cold stress, and the mean thermal gradient along the finger during rewarming, clearly separated patients from controls. After treatment with PGE1 the patients' discriminant values moved into the normal range. Symptomatic improvement after PGE1 correlated well with thermographic improvement, and both persisted for up to 12 weeks.