The Influence of Arterial Pressure on the Antihypertensive Action of a Normal Kidney, a Biological Servomechanism
Authors: LOUIS TOBIAN
Journal: Annals of Internal Medicine (1964)

Article1 March 1964The Influence of Arterial Pressure on the Antihypertensive Action of a Normal Kidney, a Biological ServomechanismLOUIS TOBIAN, M.D., F.A.C.P., SANDRA SCHONNING, B.S., CAROL SEEFELDT, B.S.LOUIS TOBIAN, M.D., F.A.C.P., SANDRA SCHONNING, B.S., CAROL SEEFELDT, B.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-3-378 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany observations suggest that the mammalian kidney has an important effect on arterial pressure. Either narrowing the renal artery (1) or compressing the kidney parenchyma (2) will induce arterial hypertension. Various renal diseases such as chronic glomerulonephritis or polycystic kidneys may bring on severe arterial hypertension. The surgical correction of a narrowed renal artery in man often produces a complete cure of an existing hypertension. Moreover, if one identical twin has severe hypertension resulting from chronic glomerulonephritis, the transplantation of a normal kidney from the other twin may bring about the disappearance of his hypertension (3).Knowing that the kidney...References1. GOLDBLATT H: Renal origin of hypertension. Physiol. Rev. 27: 120, 1947. CrossrefMedlineGoogle Scholar2. PAGE IH: The production of persistent arterial hypertension by cellophane perinephritis. JAMA 113: 2045, 1939. Google Scholar3. MERRILLMURRAYHARRISONGUILD JPJEJHWR: Successful homotransplantation of the human kidney between identical twins. JAMA 160: 277, 1956. CrossrefMedlineGoogle Scholar4. TOBIAN L: Interrelationship of electrolytes, juxtaglomerular cells and hypertension. Physiol. Rev. 40: 280, 1960. CrossrefMedlineGoogle Scholar5. SKINNERMCCUBBINPAGE SLJWIH: Route of renin release. Fed. Proc. 22: 181, 1963. Google Scholar6. LEVERPEART AFWS: Renin and angiotensin-like activity in renal lymph. J. Physiol. 160: 548, 1962. CrossrefMedlineGoogle Scholar7. CHANUTINFERRIS AEB: Experimental renal insufficiency produced by partial nephrectomy. Arch. Intern. Med. (Chicago) 49: 767, 1932. CrossrefGoogle Scholar8. WOODETHRIDGE JEC: Hypertension with arteriolar and glomerular changes in the albino rat following subtotal nephrectomy. Proc. Soc. Exp. Biol. Med. 30: 1039, 1933. CrossrefGoogle Scholar9. BRAUN-MENENDEZVON EULER EUS: Hypertension after bilateral nephrectomy in the rat. Nature 160: 905, 1947. CrossrefMedlineGoogle Scholar10. GROLLMANMUIRHEADVANATTA AEEJ: Role of the kidney in the pathogenesis of hypertension as determined by a study of the effects of bilateral nephrectomy and other experimental procedures on the blood pressure of the dog. Amer. J. Physiol. 157: 21, 1949. CrossrefMedlineGoogle Scholar11. FLOYER MA: The effect of nephrectomy and adrenalectomy upon the blood pressure in hypertensive and normotensive rats. Clin. Sci. 10: 405, 1951. MedlineGoogle Scholar12. TOBIAN L: Hypertension following bilateral nephrectomy. J. Clin. Invest. 29: 849, 1950. MedlineGoogle Scholar13. KOLFFPAGE WJIH: Blood pressure reducing function of the kidney: reduction of renoprival hypertension by kidney perfusion. Amer. J. Physiol. 178: 75, 1954. CrossrefMedlineGoogle Scholar14. KOLFFPAGECORCORAN WJIHAC: Pathogenesis of renoprival cardiovascular disease in dogs. Ibid., p. 237. Google Scholar15. HALLHALL CEO: Relative resistance to the hypertensive effects of desoxycorticosterone during the active phase of renal compensatory hypertrophy. Amer. J. Physiol. 194: 236, 1958. CrossrefMedlineGoogle Scholar16. SKELTON FR: Adrenal regeneration hypertension and factors influencing its development. Arch. Intern. Med. (Chicago) 98: 449, 1956. CrossrefGoogle Scholar17. GOMEZHOOBLERBLAQUIER AHSWP: Effects of addition and removal of a kidney transplant in renal and adrenocortical hypertensive rats. Circ. Res. 8: 464, 1960. CrossrefMedlineGoogle Scholar18. FRIEDMANFREED MCF: Microphonic manometer for the indirect determination of systolic blood pressure in the rat. Proc. Soc. Exp. Biol. Med. 70: 670, 1949. CrossrefMedlineGoogle Scholar19. HAMILTONGROLLMAN JGA: The preparation of renal extracts effective in reducing blood pressure in experimental hypertension. J. Biol. Chem. 233: 528, 1958. CrossrefMedlineGoogle Scholar20. GORDON DB: Nature of the depressor agent in extracts of rabbit kidneys. Amer. J. Physiol. 196: 1340, 1959. CrossrefMedlineGoogle Scholar21. MUIRHEADHINMANDANIELSKOSINSKI EEJWEGM: Recession of renal hypertension of dog by medullorenal extract. Fed. Proc. 22: 181, 1963. Google Scholar22. HICKLERSARAVISMOWBRAYLAULERVAGNUCCITHORN RBCAJFDPAIGW: Renomedullary vasodepressor factor. J. Clin. Invest. 42: 942, 1963. Google Scholar23. BLAQUIERBOHRHOOBLER PDFSW: Evidence against an increase in circulating pressor material in renal hypertensive rats. Amer. J. Physiol. 198: 6, 1960. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the Department of Internal Medicine, University of Minnesota Hospital and School of Medicine, Minneapolis, Minnesota.This project has been supported by grants from the American Heart Association, the Cargill Fund, and by grant H 2008 from the National Heart Institute, United States Public Health Service, Bethesda, Maryland.Requests for reprints should be addressed to Louis Tobian, M.D., University of Minnesota Medical School, Department of Medicine, Division of Internal Medicine, Minneapolis 14, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByActivation of the humoral antihypertensive system of the kidney increases diuresis.Urinary 6-keto PGF1α and PGE2 in two kidney-one clip hypertension in the ratAntihypertensive effect of transplant of rat kidney or its unclipping. Hemodynamic effects and control mechanisms.Antihypertensive functions of the kidney: Arthur C. Corcoran memorial lecture.RENAL FUNCTION AND RENAL VENOUS PROSTAGLANDIN CONCENTRATIONS DURING DIFFERENT STAGES OF EXPERIMENTAL RENAL HYPERTENSION IN THE RATRadioimmunoassay of prostaglandins A and B in human bloodAccelerated Induction of Two-Kidney Hypertension in Rats and Renin-Angiotensin SensitivityRenin, Aldosterone, Body Fluid Volumes, and the Baroreceptor Reflex in the Development and Reversal of Goldblatt Hypertension in Conscious DogsIntensivierung experimenteller Hypertonie nach Prostaglandin — Biosynthese — HemmungExperimentelle akute renale Hypertonie und exogene Angiotensin II-Gaben nach Vorbehandlung mit dem Prostaglandin-Biosynthese-Hemmer IndometacinRenal Homeostasis and the Hypertensive State: A Unifying HypothesisA viewpoint concerning the enigma of hypertensionVasoactive and Anti-hypertensive Effects of Prostaglandins and other Renomedullary LipidsRenal medullary fibrosis in hypertensionO comportam en to da pressão arterial na esquistossomose hepática e outras hepatopatiasCirculatory and Humoral Changes in the Reversal of Renovascular Hypertension in Sheep by Unclipping the Renal ArteryDer Einflu� der Leber auf den experimentellen nephrogenen Hochdruck intrarenaler GeneseZur Pathogenese der sogenannten malignen HypertonieIsolation of a Phospholipid Renin Inhibitor from Kidney *Pathophysiology of HypertensionRENIN AND HYPERTENSION 1 March 1964Volume 60, Issue 3Page: 378-383KeywordsBlood pressureGlomerulonephritisHeartHospital medicineHypertensionKidneysRenal arteriesRenal transplantationTransplantationTwins Issue Published: 1 March 1964 PDF DownloadLoading ...