tbuckley/cabot-search huggingface dataset:
Minoo S Shroff
Authors: Nazli Siddiqui
Journal: BMJ (2004)

Minoo Shroff inherited his ophthalmologist father's pioneering spirit and commitment to helping those for whom treatment was sometimes unaffordable. His father had established Dr Schroff's Charity Eye Hospital in a densely populated part of Delhi. Minoo became honorary chief medical officer at the hospital in 1948 and later surgeon emeritus.​emeritus.




Figure 1




During his tenure there he modernised and upgraded the services and expanded the hospital. His success in harnessing the Eicher Corporate Group's collaboration was largely responsible for this and meant that he could provide services to the poor of Delhi, which otherwise would have been way beyond their means.

Minoo Schroff was born in 1922 and, after qualifying at Lahore, went to England for postgraduate training before returning to India.

In 1984 Minoo and his two sons set up the Shroff Eye Centre in Kailash Colony, New Delhi. As always he kept in mind the less well off. He leaves a wife, Mehroo, and two sons.

Minoo S Shroff, senior consultant Shroff Eye Centre, Kailash Colony, New Delhi, India, and former president Delhi Ophthalmological Society (b 1922; q King Edward Medical College, Lahore; DO, DOMS, FICS), d 15 March 2004.
Antibody levels against Chlamydia pneumoniaeand outcome of roxithromycin therapy: Results from a substudy of the randomized antibiotic therapy in acute myocardial infarction (ANTIBIO) trial
Authors: Ralf Zahn, Ulrich Burckhardt, Ulrich Höffler, Birgit Frilling, Jochen Senges
Journal: Journal of the American College of Cardiology (2003)
Endoscopic v radiological techniques for rectal bleeding.
Authors: R M Charnley
Journal: Gut (1989)

Endoscopic v radiological techniques for rectal bleeding SIR, -The paper by Dr Irvine and her colleagues (Gut 1988; 29: 1188-93) compared endoscopic and radio- logical techniques for detecting colonic pathology in patients with rectal bleeding.The investigations have been reported and the results analysed meticulously but the authors are in danger of putting too much weight on the results of this study of only 71 of 315
Revascularization by Pericardial Splenosis and Pericardiopexy
Authors: David Movitz
Journal: JAMA (1963)

FOR its possibility of revascularizing an ischemicmyocardium through collaterals, production of pericardial splenosis was attempted in a series of dogs by autotransplantation of fragmented splenic tissue into the pericardial sac. Pericardial splenosis occurred in every instance and by 6 months was extensive and associated with diffuse pericardial adhesions interposed with splenotic tissue. Coronary arterial injection studies showed the splenosis to be in vascular continuity and, hence, the possibility of its functioning as a collateral supply to the coronaries. The profuse vascularity of splenic tissue, the relative simplicity of production of pericardial splenosis, and its demonstrated vascular continuity with the coronary arteries without need of epicardiectomy would appear to make pericardial splenosis a possible and practical procedure. Splenosis occurs in humans after an interval after splenectomy for ruptured spleen. The peritoneal surfaces are seeded with fragments of tissue torn from the spleen at the time of rupture and distributed by the
Arthroscopic Surgery of the Knee
Authors: Letha Y. Hunter
Journal: JAMA (1982)

<i>Arthroscopic Surgery of the Knee</i>is a concise and precise description of the use of the arthroscope as a diagnostic and operative tool in the treatment of knee disorders. Dandy first presents an excellent review of the development of endoscopic techniques from the first report of endoscopy by Bozzini in 1806 until the present. Next, he clearly outlines his techniques for diagnostic arthroscopy, giving detailed descriptions of equipment needed, organization of the operating room staff, and useful portals of entry and a guide to successful viewing of each compartment of the knee. The remainder of the text is devoted to explaining the techniques of operative arthroscopy, including synovial biopsy, loose body removal, plica resection, lateral release, chondral shaving and drilling, and partial meniscectomy. The author rightly cautions the reader that arthroscopy and arthroscopic surgery require practice and patience. "Although the results of arthroscopic surgery are remarkably successful, the procedures are
TCT-553 A Novel Endovascular Stapling Device Provides a Minimally Injurious Stent Alternative for Maintaining Lumen Patency: A 28-Day Femoral Artery Study in Swine
Authors: Athanasios Peppas, Robert Giasolli, Armando Tellez, Carol A. Burns, Gerard B. Conditt, Frank D. Kolodgie, Peter A. Schneider, Masahiko Shibuya, Renu Virmani, Greg L. Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2013)
Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.
Authors: A H Cross, T J Girard, K S Giacoletto, R J Evans, R M Keeling, R F Lin, J L Trotter, R W Karr
Journal: Journal of Clinical Investigation (1995)

T cell activation involves not only recognition of antigen presented by the MHC, but also nonspecific interactions termed "costimulation."The costimulatory molecules B7- 1 and B7-2 are ligands on antigen-presenting cells for the CD28 and CTLA-4 receptors on T cells.Previously, a fusion protein consisting of human CTLA-4 linked to human Fc was shown to bind B7-1 and B7-2 with high avidity and to prevent specific T cell activation.Here we investigated the effects of a recombinant fusion protein consisting of the extracellular domain of human CTLA-4 bound to mouse IgG2a Fc (CTLA4-Fc) upon experimental autoimmune en- cephalomyelitis, a T cell-mediated disease that serves as a model for multiple sclerosis.CTLA4-Fc prevented experi- mental autoimmune encephalomyelitis in 26 of 28 CTLA4- Fc-treated mice (median maximum score 0), whereas 28 of 30 mice treated with control mouse IgG2a developed disease (median maximum score 2.75).Less inflammation and vir- tually no demyelination or axonal loss occurred in CTLA-4-Fc-treated compared with control-treated mice.Activated splenocytes from CTLA4-Fc-treated mice were able to transfer disease adoptively to naive recipients.These results indicate a key role for the B7/CD28 system in the develop- ment of actively induced murine experimental autoimmune encephalomyelitis, suggesting an area of investigation with therapeutic potential for multiple sclerosis. (
SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR AND PLATELET DERIVED GROWTH FACTOR APPEAR TO BE NECESSARY FOR HUMAN CORONARY COLLATERALIZATION
Authors: Quinn Stanton Wells, Yan R. Su, Jared P. Leboeuf, Evan L. Brittain, Michael B. Kelley, Bobbye M. Wieman, John McPherson, Douglas B. Sawyer, Daniel J. Lenihan
Journal: Journal of the American College of Cardiology (2011)
Cardiac Care Units-Reply
Authors: Jerome A. Cooper
Journal: JAMA (1976)

It is important to delineate the perspective in which a situation is viewed. It is generally agreed that the majority of cardiac deaths occur early and outside of hospitals. Our report and the reports of the cited authors deal with the subgroup of treated patients. I believe that one should first determine whether or not we are helping these patients. If we are having a positive effect, then we should try to expand the subgroup instead of trying to see if treating those within it has a significant effect on the larger group of patients. The statement that "recent experiences with monitored cardiac care units have demonstrated that mortality can be reduced in the first few days after an acute myocardial infarction" was supported by references to Lown et al, Killip and Kimbal, and Day. Their very impressive results would make it difficult to set up a prospective
The Age of Olfactory Bulb Neurons in Humans
Authors: Olaf Bergmann, Jakob Liebl, Samuel Bernard, Kanar Alkass, Maggie S.Y. Yeung, Peter Steier, Walter Kutschera, Lars Johnson, Mikael Landén, Henrik Druid, Kirsty L. Spalding, Jonas Frisén
Journal: Neuron (2012)
Visceral analgesics and functional dyspepsia: have we found the Holy Grail?
Authors: NICHOLAS J TALLEY
Journal: Gut (1997)

See article on page664 

One of the commonest problems presenting in gastrointestinal practice is the patient with chronic or recurrent epigastric pain or discomfort where routine diagnostic testing has failed to identify a definite structural cause for the symptoms.1 Empiric antisecretory and prokinetic agents remain the mainstay of treatment for patients with a diagnosis of functional (or non-ulcer) dyspepsia, but only a minority experience complete symptom relief with these agents.2 Rational medical treatment for patients with functional dyspepsia remains an elusive goal partly because functional dyspepsia seems to comprise a heterogeneous syndrome.1 For example, approximately 50% of patients have Helicobacter pylori gastritis, up to 50% have delayed gastric emptying and perhaps 50% of patients have visceral hypersensitivity to mechanical distension of the stomach or duodenum1; clearly, these pathophysiological subsets overlap, although visceral hypersensitivity is currently postulated to be of central importance.3 4In addition to being sensitive to mechanical distension, patients with functional dyspepsia as a group may be more sensitive to other stimuli such as pentagastrin injection or intragastric infusions of acid, saline and pancreatic or biliary secretions.1 Although there is heightened visceral nocioception, somatic pain sensation is normal3 suggesting that the sensory defect is localised to the gastrointestinal tract, although these observations may also be explained by aberrant processing of signals at the spinal cord or central nervous system level.

Patients with the irritable bowel syndrome (IBS) have well documented visceral hypersensitivity to mechanical distension of the colon and small bowel.4 5 Furthermore, rectal hypersensitivity seems to be inducible in patients with IBS following mechanical stimulation of the …
Speech evolved from vocalization, not mastication
Authors: Uwe Jürgens
Journal: Behavioral and Brain Sciences (1998)

The segmentation of phonation by articulation is a characteristic feature of speech that distinguishes it from most nonhuman vocalizations. However, apart from the trivial fact that speech uses some of the same muscles and, hence the same motoneurons and motorcortical areas used in chewing, there is no convincing evidence that syllable segmentation relies on the same pattern generator as mastication. Evidence for a differential cortical representation of syllable segmentation (“frame”) and syllable “content” is also meager.
Clinical Radiation Oncology: Indications, Techniques, and Results
Authors: Walter G. Gunn
Journal: JAMA (1989)

A book that seeks to survey the indications, techniques, and results of a clinical specialty has to confront a significant dilemma at the outset. Either it ranges across all possible acceptable approaches to its subject matter (in which case it becomes massive and encyclopedic) and risks turning off most readers, or it focuses on one specific school of patient management, which may be in the mainstream on some topics but clearly outside it on others. Such individual schools of thought in the field of clinical radiation therapy began with Paterson's work from Manchester's Christie Hospital and Holt Radium Institute in the 1940s. That work set down in logical fashion the rationale and modus operandi of one of the great world centers of cancer treatment. Twenty odd years later, in the 1960s, Fletcher's group at the M. D. Anderson Hospital presented their approach to the same subject, also with a somewhat
THE COMPARATIVE VIABILITY OF PNEUMOCOCCI ON SOLID AND ON FLUID CULTURE MEDIA
Authors: L. J. Gillespie
Journal: The Journal of Experimental Medicine (1913)

1. Pneumococci, when freshly isolated from the body, are able to live and multiply when a small number of them are inoculated into a small amount of broth. If, however, the inoculations are made in large amounts of broth, many more bacteria must be inoculated in order that they may grow. 2. It requires much smaller numbers of pneumococci to start a growth on agar than are required to start a growth in broth. 3. This predilection for solid medium disappears when the bacteria are grown for some time outside the body. 4. This phenomenon is not dependent on differences in chemical composition between the two media employed or on the presence of more available oxygen in one case than in the other. 5. It is probably dependent entirely on physical differences in the two kinds of media, and bears some relation to the differences in possibilities for diffusion in the two media.
Detection of common mutations in sporadic primary localized cutaneous amyloidosis by DNA mass spectrometry
Authors: Y.-T. Chang, C.-H. Lin, C.-T. Lee, M.-W. Lin, L.-Y. Liu, C.-C. Chen, D.-D. Lee, H.-N. Liu, S.-F. Tsai, I. Matsuura
Journal: British Journal of Dermatology (2013)

Journal Article Detection of common mutations in sporadic primary localized cutaneous amyloidosis by DNA mass spectrometry Get access Y.‐T. Chang, Y.‐T. Chang Department of Dermatology National Yang‐Ming University Taipei TaiwanDepartment of Dermatology Taipei Veterans General Hospital Taipei Taiwan Search for other works by this author on: Oxford Academic Google Scholar C.‐H. Lin, C.‐H. Lin Feng Chi Biotech Corp. Taipei Taiwan Search for other works by this author on: Oxford Academic Google Scholar C.‐T. Lee, C.‐T. Lee Genome Research Centre National Yang‐Ming University Taipei Taiwan Search for other works by this author on: Oxford Academic Google Scholar M.‐W. Lin, M.‐W. Lin Department of Public Health National Yang‐Ming University Taipei Taiwan Search for other works by this author on: Oxford Academic Google Scholar L.‐Y. Liu, L.‐Y. Liu Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan Search for other works by this author on: Oxford Academic Google Scholar C.‐C. Chen, C.‐C. Chen Department of Dermatology National Yang‐Ming University Taipei TaiwanDepartment of Dermatology Taipei Veterans General Hospital Taipei Taiwan Search for other works by this author on: Oxford Academic Google Scholar D.‐D. Lee, D.‐D. Lee Department of Dermatology National Yang‐Ming University Taipei TaiwanDepartment of Dermatology Taipei Veterans General Hospital Taipei Taiwan Search for other works by this author on: Oxford Academic Google Scholar H.‐N. Liu, H.‐N. Liu Department of Dermatology National Yang‐Ming University Taipei TaiwanDepartment of Dermatology Taipei Veterans General Hospital Taipei TaiwanDepartment of Dermatology National Defense Medical Center Taipei Taiwan Search for other works by this author on: Oxford Academic Google Scholar S.‐F. Tsai, S.‐F. Tsai Institute of Molecular and Genomic Medicine National Health Research Institutes 35 Keyan Road Zhuan Miaoli 350 Taiwan Search for other works by this author on: Oxford Academic Google Scholar I. Matsuura I. Matsuura Institute of Molecular and Genomic Medicine National Health Research Institutes 35 Keyan Road Zhuan Miaoli 350 Taiwan Correspondence: Isao Matsuura. E‐mail: imatsuura@nhri.org.tw Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 4, 1 April 2014, Pages 974–976, https://doi.org/10.1111/bjd.12733 Published: 01 April 2014
Origin of neointimal endothelium and α-actin–positive smooth muscle cells in transplant arteriosclerosis
Authors: Jan-Luuk Hillebrands, Flip A. Klatter, Bart M.H. van den Hurk, Eliane R. Popa, Paul Nieuwenhuis, Jan Rozing
Journal: Journal of Clinical Investigation (2001)

The development of transplant arteriosclerosis (TA) is today's most important problem in clinical organ transplantation. Histologically, TA is characterized by perivascular inflammation and progressive intimal thickening. Current thought on this process of vascular remodeling assumes that neointimal vascular smooth muscle (VSM) cells and endothelium in TA are graft-derived, holding that medial VSM cells proliferate and migrate into the subendothelial space in response to signals from inflammatory cells and damaged graft endothelium. Using MHC class I haplotype-specific immunohistochemical staining and single-cell PCR analyses, we show that the neointimal α-actin–positive VSM cells in rat aortic or cardiac allografts are of recipient and not of donor origin. In aortic but not in cardiac allografts, recipient-derived endothelial cells (ECs) replaced donor endothelium. Cyclosporine treatment prevents neointima formation and preserves the vascular media in aortic allografts. Recipient-derived ECs do not replace graft endothelium after cyclosporine treatment. We propose that, although it progresses beyond the needs of functional repair, TA reflects the activity of a normal healing process that restores vascular wall function following allograft-induced immunological injury.
The Only Source of Freedom
Authors: Milford O. Rouse
Journal: JAMA (1967)

In making his Clinical Convention report to the House of Delegates, I believe your President should attempt a broad view of the future. I believe he should look ahead not only from the viewpoint of our profession but from a more broadly based view of the nation as a whole. If we are to build a better tomorrow, our efforts and those of all citizens must be to build the nation. We cannot be content trying to build only one corner of it. The future of the individual physician, of patient care, and of the methods by which it will be made available to all people do not depend on our efforts alone. They depend also on the future attitude of the nation toward free enterprise, on the degree of future national respect for individual initiative, and on the extent of future overall acceptance of the concept that personal satisfaction
Epicardial mapping and ablation of atrioventricular accessory pathways: correlation between success and location
Authors: Robert Schweikert, Nassir F. Marrouche, Christopher Cole, Thomas Dresing, Krzystof Balaban, David O. Martin, Ahmad Abdul-Karim, Eduardo Saad, Walid Saliba, Andrea Natale
Journal: Journal of the American College of Cardiology (2002)
Fatal Rectal Bleeding due to Tuberculosis of the Cecum
Authors: H. A. Goudarzi
Journal: JAMA (1982)

GROSS rectal bleeding is a rare presenting symptom of ileocecal tuberculosis, a disease that has become rare in the United States in recent years.<sup>1,2</sup>This case was diagnosed as Crohn's disease ten years before the fatal episode described here. <h3>Report of a Case</h3> A 65-year-old woman was admitted to the hospital for evaluation of lower abdominal pain associated with distention, nausea, and vomiting of several months' duration. She had a history of ethanol abuse and intermittent small rectal bleeding. In 1970, she had abnormal serological findings and anemia. A barium enema examination disclosed a filling defect of the terminal ileum and cecum thought to be Crohn's disease. She refused laparotomy and received a course of penicillin for the abnormal serological findings. She was emaciated and had mild icterus, slight hepatomegaly, and ascites consistent with the known history of alcoholic cirrhosis. Laboratory studies revealed the following values: WBC count, 8,200/cu
SOME SYMBOLS OF SOUND CLINICIANSHIP FOR THE DOCTOR'S BAG
Authors: David Seegal
Journal: JAMA (1961)

Medical students and house staff members are precisely informed about the diagnostic and therapeutic contents of the physician's bag so that they may meet the expected needs attendant to the house call. For 20 years the possibility of accelerating the development of mature clinicianship in the fourth-year student and the intern has been approached by examining with them certain principles, characteristic of the good doctor, which, as symbols, should<i>also</i>be in his bag. These imperatives are: (1) to respond with the phrase "I don't know" when the accurate information is not in hand, (2) to maintain the open mind for new evidence at all times, (3) to apply the Golden Rule in difficult decisions, (4) to give moral support to the patient at each visit, especially during periods of deterioration in his state of health, and (5) to bring out the latency and best qualities of the patient and
Ichemic injury on early post-transplant endomyocardial Biopsy: Immediate and long-term clinical significance
Authors: Gayle L. Winters, Maria Rosa Costanzo-Nordin, Kathleen M. Siebold, E.Jeanne O'Sulivan, Maryl R. Johnson, Roque Pifarre, Patrick J. Scanlon, John A. Robinson
Journal: Journal of the American College of Cardiology (1990)
5-Fluorouracil after Trabeculectomy and the Iridocorneal Endothelial Syndrome
Authors: Martha M. Wright, Alana L. Grajewski, Stephen M. Cristol, Richard K. Parrish
Journal: Ophthalmology (1991)

Nine patients (nine eyes) with iridocorneal endothelial (ICE) syndrome underwent trabeculectomy and received postoperative subconjunctival injections of 5-fluorouracil (5-FU) to enhance bleb formation (total 5-FU dose, 30-105 mg; mean, 53.8 mg). Eight eyes had undergone prior unsuccessful trabeculectomy. Four eyes had intraocular pressure (IOP) less than or equal to 21 mmHg on zero to two glaucoma medications after 6 to 54 months of follow-up (mean, 25.3 months). Five eyes required repeat surgery within 2 to 13 months and were considered failures. All five eyes that failed received a Molteno drainage implant. Progressive endothelial proliferation may explain late onset bleb failure and the relative ineffectiveness of 5-FU in this condition.
Abstract 19531: Impact of Bariatric Surgery on Quality of Life, Functional Capacity, and Symptoms in Patients with Heart Failure
Authors: William R Miranda, John A Batsis, Michael G Sarr, Maria L Collazo-Clavell, Matthew M Clark, Virend K Somers, Francisco Lopez-Jimenez
Journal: Circulation (2010)

Introduction: Obesity is a well-established risk factor for heart failure (HF), but the benefit of weight loss in HF has not been well documented. Hypothesis: In morbidly obese patients with established HF, bariatric surgery (BSx) improves quality of life, functional capacity and frequency of symptoms, compared to non-surgical treatment for obesity. Methods: We reviewed the outcomes of 13 patients with HF undergoing BSx and 6 HF patients followed in our Nutrition Clinic. HF was defined by a clinical diagnosis of HF, imaging test showing an ejection fraction <50%, or echocardiographic evidence of grade II-IV diastolic dysfunction. A survey assessed overall quality of life at baseline and at follow-up by using a validated single item from the Linear Analogue Self-Assessment Questionnaire (from 0 to 10 – worst to best), the frequency of HF symptoms using a Likert scale from 1 (never) to 5 (always), and functional capacity using the Specific Activity Scale (class I to IV), a measure that parallels New York He...