tbuckley/cabot-search huggingface dataset:
Linear connective tissue naevus of the proteoglycan type ('naevus mucinosus')
Authors: M. BRAKMAN, TH.M. STARINK, J. TAFELKRUYER, J.D. BOS
Journal: British Journal of Dermatology (1994)

We report a case of naevus mucinosus, a recently described condition. Clinically, the lesions presented as unilateral, multiple, firm, 3–5‐mm‐diameter, coalescent papules in a linear arrangement on the back of a 23‐year‐old man. Histologically, large amounts of acid mucoploysaccharides (proteoglycans) were demonstrated in the superficial dermis. As far as we are aware, this is the first report of the onset of naevus mucinosus in an adult. Naevus mucinosus appears to be a distinct type of connective tissue naevus which is characterized by an increase in proteoglycans.
WHO issues its first guidelines on HIV in men who have sex with men
Authors: J. Zarocostas
Journal: BMJ (2011)

The World Health Organization has issued its first public health guidelines on the prevention and treatment of HIV and other sexually transmitted infections among men who have sex with men and transgender people. The aim of the guidelines is to try to reduce new infections and increase access to essential services for people in these high risk groups.

Despite the high burden of disease among these groups, the world’s response to HIV among these groups has been insufficient, WHO says.

Men who have sex with men are nearly 20 times as likely to be infected with HIV than the general population, and infection rates among transgender …
Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells
Authors: Cathy X. Wang, Blythe D. Sather, Xuefeng Wang, Jennifer Adair, Iram Khan, Swati Singh, Shanshan Lang, Amie Adams, Gabrielle Curinga, Hans-Peter Kiem, Carol H. Miao, David J. Rawlings, Bruce E. Torbett
Journal: Blood (2014)
Aberrant expression of the transcription factor Twist in adult T-cell leukemia
Authors: H. Tanji, C. Ishikawa, S. Sawada, S. Nakachi, R. Takamatsu, T. Matsuda, T. Okudaira, J.-N. Uchihara, K. Ohshiro, Y. Tanaka, M. Senba, H. Uezato, K. Ohshima, M. Duc Dodon, K.-J. Wu, N. Mori
Journal: Blood (2010)
Chronic Effect of Fire Fighting on Pulmonary Function
Authors: John M. Peters, Gilles P. Theriault, Lawrence J. Fine, David H. Wegman
Journal: New England Journal of Medicine (1974)

Pulmonary function was studied in 1430 Boston fire fighters during the period 1970 to 1972. Questionnaire information on exposures, current respiratory symptoms and smoking habits was also collected. Forced vital capacity and forced expiratory volume in one second were measured on two occasions. The rate of loss in pulmonary function observed for the entire population was more than twice the expected rate (77 vs. 30 ml for forced vital capacity). These changes were significantly related to frequency of fire exposure (p < 0.01) and could not be explained by differences in age, smoking habits or ethnic background. This study strongly suggests that occupational exposures are contributing to chronic impairment of pulmonary function in fire fighters. (N Engl J Med 291:1320–1322, 1974)
Megaloblastic Anaemia in Congenital Spherocytosis
Authors: I. W. Delamore, J. Richmond, S. H. Davies
Journal: BMJ (1961)

M}OICAL JOUTRNAL cythaemia vera who, after venesections, developed an anaemia resembling pernicious anaemia and who responded dramatically to liver therapy.Wellington and Whitcomb (1960), however, reported the case of a patient with polycythaemia vera who, after venesections, developed an anaemia resembling perni- cious anaemia and who responded dramatically to liver therapy.This patient died from pyelonephritis following prostatectomy.At necropsy normal red-blood-cell maturation was found in the bone marrow, as was myeloid metaplasia in the spleen.The case reported by Hinz (1957) showed cerebral haemorrhage and necrosis at necropsy, but otherwise the post-mortem findings were generally similar to those in the case we have described.Summary A case is described of a woman showing megalo- blastic anaemia, who developed features of poly- cythaemia vera after treatment with liver or vitamin B12' Anaemia recurred on discontinuation of treatment.Clinical and haematological data over a period of 11 years are recorded.The patient was ultimately kept in satisfactory haematological balance with infrequenit small doses of parenteral vitamin B12'The necropsy findings are summarized.The occurrence of vitamin-B12 deficiency developing in a patient prone to myeloproliferative disorder is regarded as a coincidence.Thanks are due to Dr. W. S. Killpack, of the King Edward Memorial
The very model of a vampyre
Authors: T. Dalrymple
Journal: BMJ (2009)

To those of literary ambition but modest talent the company of writers of genius can be discouraging. No quantity of self deception is sufficient to disguise the gulf between their own productions and those of the geniuses in question; it has the same effect as coming too near a flame.

John Polidori (1795–1821) was the son of an Italian refugee in England. He attended Ampleforth College and then Edinburgh University, where he received his medical degree at the age of 19. Lord Byron selected him as companion and personal physician for his journey to the Continent that started in 1816 but discharged him after a few months because he found him bumptious, …
A retrospective study evaluating the use of Permacol™ surgical implant in incisional and ventral hernia repair
Authors: Bipan Chand, Matthew Indeck, Bradley Needleman, Matthew Finnegan, Kent R. Van Sickle, Brynjulf Ystgaard, Francesco Gossetti, Rupert D. Pullan, Pasquale Giordano, Aileen McKinley
Journal: International Journal of Surgery (2014)
Interleukin 4 suppresses the spontaneous growth of chronic myelomonocytic leukemia cells.
Authors: K Akashi, T Shibuya, M Harada, Y Takamatsu, N Uike, T Eto, Y Niho
Journal: Journal of Clinical Investigation (1991)

We studied the effects of IL-4 on the spontaneous proliferation of chronic myelomonocytic leukemia (CMMoL) cells in vitro. IL-4 (100 U/ml) suppressed the spontaneous DNA synthesis by approximately 50% in 5 of 8 cases examined. IL-4 (100 U/ml) also inhibited the spontaneous colony formation by CMMoL cells in a methylcellulose culture by 50-97% in all of the 10 cases in which spontaneous colonies were formed. This IL-4-mediated suppression of the growth of CMMoL cells was completely abolished by the addition of anti-IL-4 neutralizing antibodies. The spontaneous CMMoL colonies were substantially suppressed by the addition of either anti-IL-6 or anti-granulocyte/macrophage colony-stimulating factor (GM-CSF) antibodies to the colony assay system: the addition of both anti-IL-6 and anti-GM-CSF antibodies resulted in greater than 80% inhibition of the colony formation by CMMoL cells. On the other hand, none of anti-IL-1-beta, anti-granulocyte-CSF, anti-macrophage-CSF, or anti-tumor necrosis factor-alpha antibodies affected the CMMoL colony formation. In the supernatants from 24-h cultures of CMMoL cells, high levels of IL-6 and GM-CSF were demonstrated in 9 of 9 and 2 of 9 cases examined, respectively. IL-4 (100 U/ml) almost completely inhibited the secretion of IL-6 and GM-CSF by CMMoL cells. These observations suggest that IL-4 suppresses the spontaneous proliferation of CMMoL cells by inhibiting their production of IL-6 and/or GM-CSF, both of which could act in vitro as an autocrine growth factor for CMMoL cells.
Krüppel-like factor 6 regulates mitochondrial function in the kidney
Authors: Sandeep K. Mallipattu, Sylvia J. Horne, Vivette D’Agati, Goutham Narla, Ruijie Liu, Michael A. Frohman, Kathleen Dickman, Edward Y. Chen, Avi Ma’ayan, Agnieszka B. Bialkowska, Amr M. Ghaleb, Mandayam O. Nandan, Mukesh K. Jain, Ilse Daehn, Peter Y. Chuang, Vincent W. Yang, John C. He
Journal: Journal of Clinical Investigation (2015)

Maintenance of mitochondrial structure and function is critical for preventing podocyte apoptosis and eventual glomerulosclerosis in the kidney; however, the transcription factors that regulate mitochondrial function in podocyte injury remain to be identified. Here, we identified Krüppel-like factor 6 (KLF6), a zinc finger domain transcription factor, as an essential regulator of mitochondrial function in podocyte apoptosis. We observed that podocyte-specific deletion of Klf6 increased the susceptibility of a resistant mouse strain to adriamycin-induced (ADR-induced) focal segmental glomerulosclerosis (FSGS). KLF6 expression was induced early in response to ADR in mice and cultured human podocytes, and prevented mitochondrial dysfunction and activation of intrinsic apoptotic pathways in these podocytes. Promoter analysis and chromatin immunoprecipitation studies revealed that putative KLF6 transcriptional binding sites are present in the promoter of the mitochondrial cytochrome c oxidase assembly gene (SCO2), which is critical for preventing cytochrome c release and activation of the intrinsic apoptotic pathway. Additionally, KLF6 expression was reduced in podocytes from HIV-1 transgenic mice as well as in renal biopsies from patients with HIV-associated nephropathy (HIVAN) and FSGS. Together, these findings indicate that KLF6-dependent regulation of the cytochrome c oxidase assembly gene is critical for maintaining mitochondrial function and preventing podocyte apoptosis.
OBSERVATIONS IN LARYNGOTOMY; TRACHEOTOMY; INTUBATIONS; BASED ON CLINICAL AND EXPERIMENTAL EVIDENCE.
Authors: GEORGE W. CRILE
Journal: JAMA (1900)

The animals were all reduced to full surgical anesthesia by ether before the experiments were begun, and were killed before recovery therefrom. Respiratory tracings were obtained by means of a rubber tambour, attached to a canvas band, encirling three-fourths of the circumference of the animal's chest. This energized a writing style attached to an organ-key mechanism. Respiratory tracings were obtained very accurately. Blood-pressure was recorded by means of a mercury manometer. The drums were revolved by a mechanism so made as to be capable of a variety of movements, ranging from one revolution in thirty minutes to eighteen per minute, so that any phase of any given tracing might be duly recorded. The following is a part of a rather extended research, which enabled us to estimate the reliable reduction with comparatively few experiments. Surgeons have not infrequently encountered, in performing a laryngotomy, sudden collapse at the moment when the
Spinal Subarachnoid Hematoma
Authors: S. S. Brem, D. A. Hafler, R. L. van Uitert, Robert L Ruff, W. H. Reichert
Journal: New England Journal of Medicine (1981)

HEMORRHAGE into the spinal canal can be a complication of lumbar puncture,1 especially when coagulopathy is present. The spinal subdural and epidural spaces are well-recognized sites of possible hematomas that result in compressive myelora-diculopathy.2 3 4 We describe two patients in whom paraplegia due to subarachnoid hematoma developed after lumbar puncture and anticoagulation. A review of cases treated at the New York Hospital indicates that paraplegia and back pain after puncture may be a serious hazard after anticoagulation.Case ReportsCase 1An 81-year-old man awoke with symptoms and signs of an ischemic stroke of the right lateral medulla. A coagulation profile . . .
Flat feet in children.
Authors: M A Smith
Journal: BMJ (1990)

within 24 hours after the onset of continuous chest pain are given thrombolytic treatment.Patients with ST depression or deep T wave inversion are at first treated for unstable angina with heparin, aspirin, nitrates, and ri blockers.If chest pain persists after two hours and electrocardiographic changes show no tendency to resolve myocardial infarction is assumed and streptokinase infusion started.Early resolution of electro- cardiographic changes, on the other hand, is taken to indicate reversible ischaemia requiring no additional treatment.No patient with a normal electrocardiogram receives thrombolytic treatment.
High BRE expression predicts favorable outcome in adult acute myeloid leukemia, in particular among MLL-AF9–positive patients
Authors: Sylvie M. Noordermeer, Mathijs A. Sanders, Christian Gilissen, Evelyn Tönnissen, Adrian van der Heijden, Konstanze Döhner, Lars Bullinger, Joop H. Jansen, Peter J. M. Valk, Bert A. van der Reijden
Journal: Blood (2011)
Ophthalmoplegia, amblyopia, and diffuse encephalomyelitis associated with pelvic abscess.
Authors: B Williams, T N Ghosh, R A Stockley
Journal: BMJ (1979)

Ophthalmoplegia, amblyopia, and diffuse encephalomyelitis associated with pelvic abscess Duke-Elder' included focal sepsis as a cause of optic neuritis, though he thought the association was uncommon.We describe here a patient who presented with optic neuritis with no apparent cause but whose neuro-ophthalmological symptoms disappeared after removal of a pelvic abscess. Case reportAn 18-year-old girl was admitted with a two-week history of headaches, backache, neck stiffness, and hyperacusis.One week before admission she developed intermittent diplopia, failing vision, and ataxia.Her last period had occurred three and a half months earlier.There was no history of drug abuse.
456 HCC PERSISTENCE OR RECURRENCE AFTER BRIDGING THERAPY HELPS PREDICT TRANSPLANT LIST DROPOUT AND GENERATE A MORE EQUITABLE EXCEPTION POLICY
Authors: M. De Giorgio, S. Vezzoli, E. Cohen, E. Armellini, M.G. Lucá, G. Verga, D. Pinelli, R. Nani, M. Colledan, S. Fagiuoli, M. Strazzabosco
Journal: Journal of Hepatology (2009)
Unmasking the Heterogeneity of Acute Lymphoblastic Leukemia
Authors: Erwin W. Gelfand, Boris E. Chechik
Journal: New England Journal of Medicine (1976)

Recognition of cell-surface markers for lymphocytes of T-cell or B-cell origin led to the suggestion that leukemias and lymphomas could be classified on the basis of cell origin or cell characteristics. Acute lymphoblastic leukemia has long been recognized to be a heterogeneous disease on the basis of clinical presentation, response to chemotherapy, course and prognosis. Despite this clinical heterogeneity, lymphoblasts in this disease appear morphologically indistinguishable. Since Minowada, Ohnuma and Moore1 observed that lymphoblasts from a cell line established from a patient with the disorder had surface characteristics of T lymphocytes, a large number of investigators have attempted to determine . . .
Disaster Aid App
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Netherlands tops European healthcare league, with UK coming in at 12th
Authors: R. Watson
Journal: BMJ (2012)

For the third time in a row the Netherlands has come top in an exercise to gauge which country’s residents are most satisfied with their healthcare system, have the best outcomes, and have the best access to healthcare and drugs.

The Netherlands came top of the Euro Health Consumer Index, which is produced by the Swedish think tank Health Consumer Powerhouse.1 With 872 points out of a possible 1000, the country emerged well ahead of Denmark (822), Iceland (799), Luxembourg (791), and Belgium (783).⇓



Health Consumer Powerhouse

The United Kingdom, with 721 points, was placed equal 12th with Ireland and Austria among the 34 countries surveyed—two places higher than its ranking in the previous index produced in 2009.

Overall, the index points to …
Predictive Factors of Failure in a Fixed 15 mCi 131I-Iodide Therapy for Graves’ Disease
Authors: Arnaldo Moura-Neto, Camila Mosci, Allan O. Santos, Barbara J. Amorim, Mariana C. L. de Lima, Elba C. S. C. Etchebehere, Marcos Antonio Tambascia, Celso Dario Ramos, Denise Engelbrecht Zantut-Wittmann
Journal: Clinical Nuclear Medicine (2012)

To investigate the factors influencing the success rate in a fixed, 15 mCi approach for treatment of Graves' hyperthyroidism.The thyroid function outcome (hyperthyroidism or euthyroidism/hypothyroidism) was verified at least 1 year after radioiodine therapy (RIT) retrospectively and compared with presenting clinical characteristics and pre-RIT parameters in 87 patients treated with I-iodide for Graves' disease in a tertiary care center.After RIT, 16 patients (18.4%) became euthyroid, 54 patients (62.1%) became hypothyroid, and 17 (19.5%) remained hyperthyroid. We found no statistically significant association between thyroid function outcome and gender (P = 0.50), ophthalmopathy (P = 0.69), drug used (methimazole or propylthiouracil; P = 1.00), maintenance or withdrawal of thionamides pre-RIT (P = 0.98), or 99mTc sodium pertechnetate thyroid uptake prior to RIT (P = 0.75). The only variable associated with the success rate was thyroid mass <62 g (P < 0.001).Our study has shown that a fixed 15 mCi approach for treatment of Graves' disease was effective, but high failure rates were observed in patients presenting larger goiters, particularly those with estimated thyroid mass >62 g.
No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities
Authors: A V Moorman, S C Raimondi, C-H Pui, A Baruchel, A Biondi, A J Carroll, E Forestier, P S Gaynon, J Harbott, D O Harms, N Heerema, R Pieters, M Schrappe, L B Silverman, E Vilmer, C J Harrison
Journal: Leukemia (2005)
Is there a cure for drug errors?
Authors: R E Ferner
Journal: BMJ (1995)

Drug errors are avoidable but difficult to avoid. The prescriber has to be knowledgeable enough to choose an effective treatment suitable for the individual patient, taking into account age, infirmity, and possible interactions with other drugs. Having selected the right agent and the correct dose, the prescriber has to transmit the message to the dispenser, who has then to hand the drug to the patient or to a carer or nurse, who has to see that the drug is given in the correct way and at the specified times. The process is complex, and, not surprisingly, errors occur. Their frequency is difficult to estimate. As with air travel, deaths are sufficiently rare that “near misses” are important. More important still is to devise a strategy for reducing errors.

Bates et al have recently reported a study from Boston in which they identified about 6.5 actual and 5.5 potential adverse drug events—errors or adverse reactions involving drug treatment—per 100 hospital patients.1 Over a quarter of the observed events resulted from errors, and these were generally more serious than the adverse reactions. Drug errors are clearly an important cause of morbidity in hospital2 3 4 and probably in general practice. …
The Double Face of Janus and Other Essays in the History of Medicine
Authors: Lester S. King
Journal: JAMA (1977)

Owsei Temkin, outstanding historian of medicine, is now celebrating his 75th birthday. In honor of the occasion, the Johns Hopkins Press has just republished some of his earlier papers, together with a new autobiographical essay that provides the title for the book. Early in his university career in Leipzig, Temkin was undecided between medicine and philosophy. He chose medicine. Then, under the influence of Henry Sigerist, he became especially concerned with the history of medicine. After receiving his medical degree, he did not practice but devoted himself to the history of medicine, a field in which he was able to synthesize his interests in philosophy, history, and medicine. In 1932 he emigrated to this country, joining Sigerist at the then new Institute for the History of Medicine at the Johns Hopkins Medical School, where he has spent his entire professional career. The autobiographical essay tells of his own development but
223 Effects of midodrine vs effects of midodrine plus octreotide on systemic hemodynamics and renal function in nonazotemic cirrhotic patients with ascites
Authors: G. Kalambokis, M. Economou, A. Fotopoulos, G. Albuharali, C. Pappas, K. Pappas, E.V. Tsianos
Journal: Journal of Hepatology (2006)
CHRONIC LYMPHATIC LEUKEMIA WITH ALEUKEMIC BLOOD PICTURE
Authors: Edward Weiss
Journal: JAMA (1928)

<h3>History.</h3> —G. B., a white man, aged 55, a painter, admitted to the service of Dr. Solis-Cohen at the Jefferson Hospital, May 4, 1927, complained of weakness, vague pains in the back and abdomen, and swelling of the legs. The family history was negative. He had always enjoyed good health. He had had frequent sore throats in early life and diphtheria at 18, but no serious illnesses. He had married at 25 and had five children living and well. He never had venereal disease. For the last several years he occasionally suffered fleeting joint pains. For the past year, the patient had been unable to work regularly because of progressive weakness and shortness of breath on exertion; during the last month he had had swelling of the legs. The patient was pale. There was no cyanosis or clubbing. There was slight infection of the gums, but no blue line. The
Epithelial P2X purinergic receptor channel expression and function
Authors: Amanda L. Taylor, Lisa M. Schwiebert, Jeffrey J. Smith, Chris King, Julie R. Jones, Eric J. Sorscher, Erik M. Schwiebert
Journal: Journal of Clinical Investigation (1999)

P2X purinergic receptor (P2XR) channels bind ATP and mediate Ca2+ influx — 2 signals that stimulate secretory Cl– transport across epithelia. We tested the hypotheses that P2XR channels are expressed by epithelia and that P2XRs transduce extracellular ATP signals into stimulation of Cl– transport across epithelia. Electrophysiological data and mRNA analysis of human and mouse pulmonary epithelia and other epithelial cells indicate that multiple P2XRs are broadly expressed in these tissues and that they are active on both apical and basolateral surfaces. Because P2X-selective agonists bind multiple P2XR subtypes, and because P2X agonists stimulate Cl– transport across nasal mucosa of cystic fibrosis (CF) patients as well as across non-CF nasal mucosa, P2XRs may provide novel targets for extracellular nucleotide therapy of CF.
Attempt to delay bill on personal care is defeated in House of Lords
Authors: A. Gulland
Journal: BMJ (2010)

An attempt to delay a bill giving the most vulnerable people free personal care in their own homes has been thrown out by the House of Lords.

The Personal Care at Home Bill was announced by Gordon Brown at last year’s Labour Party conference and then formed part of the Queen’s speech. However, former Labour health minister Lord Warner, who proposed the motion to block the bill, said it was unaffordable and proper consultation had not taken place.

Conservative peer Baroness Gardner of Parkes said the bill was being introduced in an “ill considered way.” “The timing and speed of the bill are also unfortunate. Bringing it …