tbuckley/cabot-search huggingface dataset:
Hospital readmission for adult acute sickle cell painful episodes: frequency, etiology, and prognostic significance
Authors: Samir K. Ballas, Margaret Lusardi
Journal: American Journal of Hematology (2005)

The acute sickle cell painful episode is the most common cause of hospitalization of patients with sickle cell anemia. Its detailed clinical features and peri-discharge features are not well known. In order to determine the actual pattern of hospital admissions of patients with SS and the causes of frequent hospital readmissions and their prognostic significance, we conducted a prospective longitudinal and observation cohort study of all adult patients with sickle cell anemia admitted to Thomas Jefferson University Hospital between January 1998 and December 2002. Major outcome measures included the frequency, etiology, and prognostic significance of readmissions to the hospital within 1 week and 1 month after discharge. Incidence of mortality among patients during the study period was also determined. Analysis of the data showed that about 50% of hospital admissions for acute painful episodes were readmitted within 1 month after discharge, and about 16% of all admissions were within 1 week after discharge. The intensity of pain score decreased significantly during the first 4 days of hospital admission (P < 0.001) and then reached a plateau until discharge. The mean score of pain intensity was >7 throughout the hospital stay. Causes of hospital readmission included premature discharge, withdrawal syndrome, and recurrence of new acute episodes. Readmission within 1 week after discharge was associated with higher mortality than otherwise. This study shows that hospital readmission of adult patients with sickle cell anemia is common. It suggests that improvement is needed in the management of pain during hospitalization and at home after discharge. Patients who are readmitted frequently within 1 week of discharge have poor prognosis and require careful monitoring.
Effects of Cost Sharing in Health Insurance
Authors: Rashi Fein
Journal: New England Journal of Medicine (1981)

In 1970, personal health expenditures in the United States totaled $65 billion. In 1980, this figure had risen to $218 billion.1 It is therefore not surprising that discussions about existing health-insurance coverage and possible alternative ways of financing medical care have been concerned not only with how these costs might be shared but also with how they might be contained.Since total costs are affected by the degree to which services are used, various devices designed to restrain the use of services have been suggested. Third parties (insurance and government) pay for most health-care costs, and so cost-sharing proposals, such . . .
Social-affective origins of mindreading and metacognition
Authors: Philippe Rochat
Journal: Behavioral and Brain Sciences (2009)

Abstract The engineer's look at how the mind works omits a central piece of the puzzle. It ignores the dynamic of motivations and the social context in which mindreading and metacognition evolved and developed in the first place. Mindreading and metacognition derive from a primacy of affective mindreading and meta-affectivity (e.g., secondary emotions such as shame or pride), both co-emerging in early development.
Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation
Authors: Anna Rita Migliaccio, Fabrizio Martelli, Maria Verrucci, Massimo Sanchez, Mauro Valeri, Giovanni Migliaccio, Alessandro Maria Vannucchi, Maria Zingariello, Angela Di Baldassarre, Barbara Ghinassi, Rosa Alba Rana, Yvette van Hensbergen, Willem E. Fibbe
Journal: Blood (2009)
Variation in Leukaemia Incidence
Authors: P. Lanzkowsky
Journal: BMJ (1964)

MEDXCsJOURNALtrue, but the significance of the appeal is all too often overlooked.Mr. Philipp writes: " Vomiting in early pregnancy is almost physiological."May I modify this statement with my own view that vomiting in early pregnancy is almost cer- tainly physiological.In a lecture to the Royal College of Midwives (1963) on the " Emo- tional Hygiene of Pregnancy " I outlined my theory of the protective function of preg- nancy sickness.In support of this theory, in a study of 100 first pregnancies, I adduced a quantity of evidence of a kind which is commonly withheld.This evidence will appear in detail in an article now in course of publication, and it is summarized briefly as follows: (1) The risk of abortion is greatest during the early weeks of pregnancy, when sickness is common.(2) Sickness is far commoner in first pregnancies, when the amorous relationship of recent marriage is most intense. (3)Paradoxically, sickness seldom occurs if there is a frank threat of abortion, even though this be no more than a trace of blood.(4) Sickness is significantly less common in unmarried primigravidae when they are removed from the probability of intercourse.-Iam, etc.,
Flagging Th17 in Crohn's
Authors: Amy Maxmen
Journal: The Journal of Experimental Medicine (2009)

It doesn't take much to set off certain Th17 cells lurking in the intestines of patients with Crohn's disease. And on [page 525][1], Kleinschek et al. find a marker that pinpoints those easy-to-incite cells.

![Figure][2] 

CD 161+ T cells from patients with Crohn's disease preferentially
Hepatic Hydrothorax Scintigraphic Confirmation
Authors: CHAN H. PARK, CHINH D. PHAM
Journal: Clinical Nuclear Medicine (1995)

The development of a large hydrothorax (usually on the right side) in patients with advanced hepatic cirrhosis and in the absence of clinical ascites is called hepatic hydrothorax. The condition Is because of a transdiaphragmatic communication between the peritoneal and pleural cavities through defects in the tendinous portion of the diaphragm. A case of right hepatic hydrothorax demonstrated a rapid accumulation of radioactivity in the right pleural effusion after intraperitoneal injection of Tc-99m MAA under ultrasound guidance. The unidirectional transdiaphragmatic flow of ascitic fluid into the pleural cavity after intraperitoneal injection of either Tc- 99m MAA or Tc-99m SC, as in this case, is a confirmatory finding of hepatic hydrothorax.
People who feel younger tend to live longer, say researchers
Authors: J. Wise
Journal: BMJ (2014)

Older people who feel younger than their chronological age have a lower death rate than those who feel their age or older, a new study has found.

A research letter in the journal JAMA Internal Medicine1 analysed data from the English Longitudinal Study of Ageing, which asked 6489 people with a mean age of 65.8 years how old they actually …
Correction: Beryllium Disease
Authors: Milton D. Rossman
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 April 1989Correction: Beryllium DiseaseMilton D. Rossman, MDMilton D. Rossman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-8-672 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Unfortunately, I have discovered an error in my manuscript published in the May 1988 issue (1). In the last paragraph of the results section on page 690, the second and third sentences are incorrect and should be corrected to read: "The four beryllium patients, who according to biopsy and clinical course did not have chronic beryllium disease, and the two patients with clinical features not suggestive of chronic beryllium disease, did not have positive bronchoalveolar cell proliferation tests. The three patients with probable chronic beryllium disease had a positive bronchoalveolar proliferation test to beryllium."...Reference1. Rossman M, Kern J, and Elias J. Proliferative response of bronchoalveolar lymphocytes to beryllium: a test for chronic beryllium disease. Ann Intern Med. 1988;108:687-93. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Milton D. Rossman, MDAffiliations: Hospital of the University of Pennsylvania Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1989Volume 110, Issue 8Page: 672-672KeywordsBiopsyCell proliferationPatients ePublished: 1 December 2008 Issue Published: 15 April 1989 PDF downloadLoading ...
827 LIVER STEATOSIS EVALUATED THROUGH CHEMICAL-SHIFT MAGNETIC RESONANCE IMAGING AND LIVER ENZYMES; EFFECT OF WEIGHT LOSS OBTAINED WITH INTRAGASTRIC BALLOON AND GASTRIC BANDING
Authors: L. Folini, S. Garbossa, A. Benetti, C. Pozzato, A. Veronelli, E. Masci, M. Cappelletti, G. Micheletto, A.E. Pontiroli
Journal: Journal of Hepatology (2011)
Interleukin-8 and neutrophils in systemic sclerosis with lung involvement.
Authors: B Crestani, N Seta, E Palazzo, C Rolland, P Venembre, M Dehoux, A Boutten, P Soler, M C Dombret, M F Kahn
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

We investigated the mechanisms and consequences of neutrophil accumulation in the airspace in 11 patients with systemic sclerosis (SSc) and interstitial lung disease. Seven normal subjects served as controls. We measured total neutrophil elastase burden, elastase activity, and alpha-1-antitrypsin (alpha 1AT) in bronchoalveolar lavage (BAL) fluid and we evaluated the in vitro interleukin-8 (IL-8, a potent chemoattractant for neutrophils) secretion by alveolar macrophages (AM). A mild neutrophil alveolitis was observed in patients when compared with control subjects. Total BAL elastase burden was higher in patients than in control subjects and correlated positively with the percentage of neutrophils in BAL. BAL elastase activity was undetectable in control subjects, but it was detected in all patients but one (mean: 257 +/- 87 mU/L). Spontaneous IL-8 secretion by AM was higher in patients with SSc than in control subjects (518 +/- 115 versus 228 +/- 65 ng/ml, p = 0.04) and positively correlated with the percentage of neutrophils in BAL (r = 0.505). We conclude that (1) the neutrophil could participate in the pathogenesis of SSC lung disease through the release of elastase; (2) the AM could contribute to the influx of neutrophils in the alveolus through the release of IL-8.
Lung Cancer and Vehicle Exhaust in Trucking Industry Workers
Authors: Eric Garshick, Francine Laden, Jaime E. Hart, Bernard Rosner, Mary E. Davis, Ellen A. Eisen, Thomas J. Smith
Journal: Environmental Health Perspectives (2008)

An elevated risk of lung cancer in truck drivers has been attributed to diesel exhaust exposure. Interpretation of these studies specifically implicating diesel exhaust as a carcinogen has been limited because of limited exposure measurements and lack of work records relating job title to exposure-related job duties.We established a large retrospective cohort of trucking company workers to assess the association of lung cancer mortality and measures of vehicle exhaust exposure.Work records were obtained for 31,135 male workers employed in the unionized U.S. trucking industry in 1985. We assessed lung cancer mortality through 2000 using the National Death Index, and we used an industrial hygiene review and current exposure measurements to identify jobs associated with current and historical use of diesel-, gas-, and propane-powered vehicles. We indirectly adjusted for cigarette smoking based on an industry survey.Adjusting for age and a healthy-worker survivor effect, lung cancer hazard ratios were elevated in workers with jobs associated with regular exposure to vehicle exhaust. Mortality risk increased linearly with years of employment and was similar across job categories despite different current and historical patterns of exhaust-related particulate matter from diesel trucks, city and highway traffic, and loading dock operations. Smoking behavior did not explain variations in lung cancer risk.Trucking industry workers who have had regular exposure to vehicle exhaust from diesel and other types of vehicles on highways, city streets, and loading docks have an elevated risk of lung cancer with increasing years of work.
Psychological Factors in the Treatment of Chronic Low Back Pain
Authors: Juhani Julkunen, Heikki Harri, Jarmo Kankainen
Journal: Psychotherapy and Psychosomatics (1988)

The aim of the study was to investigate the role of certain psychological factors (e.g. neurotic features, alexithymia, and hostility) as intervening variables modifying the outcome of the back school intervention or correlating with spontaneous recovery. The results indicated that those patients who reacted favorably to the back school intervention could be described as emotionally well adjusted and controlled showing relatively good cognitive capacity with undisturbed reality testing. The poor responders in the treatment group were less capable cognitively and not so well balanced emotionally. Patients showing spontaneous recovery in the control group were characterized by a more lively and less controlled way of expressing emotions and affects. In contrast to these, patients who showed increasing disability during the 1-year follow-up were characterized by restricted expression of emotions and affects indicating alexithymia.
Heterodox Notions on Pathways of Steroidogenesis*
Authors: SEYMOUR LIEBERMAN, V. V. K. PRASAD
Journal: Endocrine Reviews (1990)

WIDELY accepted dogmas in the life sciences often require revision. Some of these revisions are made necessary not by the subsequent correction of faulty data but rather by the fact that the dogmas are founded on data that, although accurate, do not allow for a single, unequivocal interpretation. In many such instances, the dogma arises when experimental data are considered in the light of contemporary conceptions. These evoke the most obvious explanations which, in turn, with the passage of time become cherished beliefs. This is true even when an alternative and sometimes equally logical explanation of the experimental data provides a different view of the natural situation, one that is no less tenable than the original proposal. Several years ago we examined in some detail the proposition that the true intermediates in the biosynthetic processes leading to the formation of the steroid hormones are enzyme-bound, transient species that proceed from precursor to hormonal products by means of concerted reactions (1).
Abstract 2699: Identification and characterization of active components of antrodia cinnamomea mycelia on targeting cancer initiating cells
Authors: Meng-Chia Wu, Jeng-Fan Lo
Journal: Cancer Research (2014)

Abstract Background: Cancer initiating cells (CICs) are a subtype of cancer cells, which have the enhanced stemness properties and tumorigenic abilities. CICs are also considered to render resistance of chemotherapy, then, result in recurrence and metastasis. Recent researches and our discovery show that elevated activity of aldehyde dehydrogenase (ALDH) is closely related to CICs. Development of drugs that can specific target cancer initiating cells as a therapeutic method to against the disease would benefit for treatment of cancer patients. Methods: We first used the ALDH assay to screen for purified compounds of the myceluim from Antrodia Cinnamomea with inhibitory activity in cancer cells. Then, we find out 4-acetylantroquinonol B (4-AAQN B) significantly down regulated the ALDH activity after its administration. Further, the anticancer activity of 4-AAQN B by targeting CICs will be identified both in vitro and in vivo. Results: Our results showed that ALDH activity and stemness marker CD44, uPAR, CCN1 significantly decreased after 4-AAQN B administration. We also observed the decreased cell viability in cancer cells. On note, 4-AQQN B reduced ROS high cells, which are considered as activated CICs. Conclusion: The anticancer activity of has been reported before. However, we are the first group to confirm that 4-AAQN B can selectively target CICs. The abovementioned findings provide an alternative therapeutics for future cancer treatment in combination with conventional chemotherapy. Citation Format: Meng-Chia Wu, Jeng-Fan Lo. Identification and characterization of active components of antrodia cinnamomea mycelia on targeting cancer initiating cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2699. doi:10.1158/1538-7445.AM2014-2699
Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms.
Authors: A Hartwig, M Asmuss, I Ehleben, U Herzer, D Kostelac, A Pelzer, T Schwerdtle, A Bürkle
Journal: Environmental Health Perspectives (2002)

Nickel, cadmium, cobalt, and arsenic compounds are well-known carcinogens to humans and experimental animals. Even though their DNA-damaging potentials are rather weak, they interfere with the nucleotide and base excision repair at low, noncytotoxic concentrations. For example, both water-soluble Ni(II) and particulate black NiO greatly reduced the repair of DNA adducts induced by benzo[a]pyrene, an important environmental pollutant. Furthermore, Ni(II), As(III), and Co(II) interfered with cell cycle progression and cell cycle control in response to ultraviolet C radiation. As potential molecular targets, interactions with so-called zinc finger proteins involved in DNA repair and/or DNA damage signaling were investigated. We observed an inactivation of the bacterial formamidopyrimidine-DNA glycosylase (Fpg), the mammalian xeroderma pigmentosum group A protein (XPA), and the poly(adenosine diphosphate-ribose)polymerase (PARP). Although all proteins were inhibited by Cd(II) and Cu(II), XPA and PARP but not Fpg were inhibited by Co(II) and Ni(II). As(III) deserves special attention, as it inactivated only PARP, but did so at very low concentrations starting from 10 nM. Because DNA is permanently damaged by endogenous and environmental factors, functioning processing of DNA lesions is an important prerequisite for maintaining genomic integrity; its inactivation by metal compounds may therefore constitute an important mechanism of metal-related carcinogenicity.
Effects of Sildenafil Citrate (Viagra®) on Hemodynamic Parameters during Exercise Testing and Occurrence of Ventricular Arrhythmias in Patients with Erectile Dysfunction and Cardiovascular Disease
Authors: Yoram Vardi, Mondir Bulus, Shimon Reisner, Suliman Nassar, Louis Aboud, Elliot Sprecher, Ilan Gruenwald
Journal: European Urology (2003)
Jewish paper forgoes tobacco advertising
Authors: J. Siegel-Itzkovich
Journal: BMJ (1997)

An Orthodox Jewish weekly newspaper has become the first Israeli publication to voluntarily forgo tobacco advertisements after the spiritual mentor of the political party that owns the newspaper declared that smokers “deserve 40 lashes” and that those who manufacture and market cigarettes “sin and will suffer divine punishment.”

The Jerusalem based weekly Yom Le' Yom (meaning “day to day”) …
Explained Unexplained Anisocoria
Authors: William V. Delaney
Journal: JAMA (1980)

UNEQUAL pupils, loss of accommodation, inconsistent field loss, and double vision in near gaze prompted neurological evaluation of a patient. Discontinuation of diphenhydramine hydrochloride therapy for allergies resulted in immediate and permanent reversal of all symptoms and signs. The atropine-like effect of antihistamines needs reemphasis. <h3>Report of a Case</h3> In December 1978, a 14-year-old girl was referred by a neurosurgeon because of persistent complaints about her vision in the left eye. She had had difficulty reading in school throughout the previous year and had not done well academically. In July 1978, she had "passed out" while at school, without any incontinence or convulsion. The episode was brief and associated with a headache. She was subsequently examined by two ophthalmologists, who found an inferior nasal field defect in both of her eyes and a possible superior temporal defect in the left. She described blurred vision in the left eye and was
Electrocardiographic Diagnosis of Myocardial Infarction in the Presence of Left Bundle-Branch Block
Authors: MYRON G. CHAPMAN, MORTON LEE PEARCE
Journal: Circulation (1957)

It is generally accepted that most myocardial infarctions are obscured on the electrocardiogram by left bundle-branch block. The number of published cases in which this could be evaluated, however, is small, and the case reports are scattered. We have studied 30 cases of myocardial infarction with left bundle-branch block in which the location of the infarction could be determined with certainty, by autopsy, or by a previous electrocardiogram with normal intraventricular conduction. Twenty such published cases have also been collected. Electrocardiographic abnormalities have been correlated with infarctions in different locations. The possible specificity of these abnormalities is discussed.
PHENELZINE IN THE TREATMENT OF DEPRESSION
Authors: HENRY V. AGIN
Journal: American Journal of Psychiatry (1963)

Phenelzine provides effective therapy for the treatment of depressed patients, and is especially effective in patients in the older age groups. Because of its safety and lack of severe side effects, it should be used in preference to ECT, except when the threat of suicide is acute or an immediate improvement is required, without regard to other factors.
Colour vision in vitamin A deficiency.
Authors: V Reddy, None Vijayalaxmi
Journal: BMJ (1977)

81suggests, as do our data, that responses to 1-x-OHD, and I-ax, 25-(OH)2D, are different enough to have important implications in treatment.Although hypercalcaemia remains a serious risk with all vitamin D derivatives the rapid reversal that is possible after I-x, 25-(OH),D, treatment makes this agent preferable to calciferol and possibly to 1-x-OHD,.This is particularly so in patients in whom hypercalcaemia is most likely to be troublesome -for example, those with precarious renal function, or those in whom hypercalcaemia has been previously induced.
Surgery for cardiac complications caused by endocardial mural fibrin deposits in a hypereosinophilic syndrome.
Authors: G Fournial, R Schlanger, F Berthoumieu, J Pris, J Marco, H Eschapasse
Journal: Circulation (1982)

A 31-year-old man presented with rapid onset of intractable congestive heart failure during the course of chemotherapy for eosinophilic leukemia. Patients with a hypereosinophilic syndrome usually die from complications of eosinophilic infiltration and fibrosis in target organs. The resulting cardiac lesions are a cause of death among these patients. Surgical intervention enabled our patient to survive the immediate medical crisis and has prolonged his life.