tbuckley/cabot-search huggingface dataset:
MEDICAL CARE OF INEBRIATES.
Authors: T. D. CROTHERS
Journal: JAMA (1907)

Inebriates rarely ever appeal to physicians for help, unless intoxicated, or in the remorseful period, when recovering from the toxic effects. The moderate drinker never considers the need of medical help. The periodic drinker may seek advice on the eve of an outbreak, but never after, until the storm is over, and he is suffering from the effects of the excess.  The friends of patients frequently ask physicians about these conditions, and sometimes bring the patient with them, who is always skeptical of the need of help. As a rule, physicians look on inebriety as a moral condition of half vice, with mental indolence and feeble will.  The first impression is to alarm the patient and to try to impress on him a fear and horror of his condition, and in this way to rouse up an antagonism to the drink impulse, or the quack method may be tried, of
Hepcidin: what every gastroenterologist should know
Authors: A P Walker
Journal: Gut (2004)

The circulating peptide hepcidin is important in the normal response to iron overload, the pathogenesis of haemochromatosis, and possibly the anaemia of chronic disease

In health, the body content of iron is maintained within fairly narrow limits to provide sufficient iron for synthesis of ferroproteins essential for oxygen transport and catalysis yet avoid the toxic effects of excess. Early experiments provided tantalising evidence for a humoral regulatory factor. Serum obtained from iron repleted rats inhibited iron absorption in normal rat duodenum.1 For many years this putative factor remained elusive. However, recent studies indicate that a peptide hormone, hepcidin, may play a crucial regulatory role in normal iron homeostasis, haemochromatosis, and the anaemia of chronic disease.2

Hepcidin was identified not from studies of iron homeostasis but from investigation of novel antimicrobial peptides in body fluids. Krause and colleagues3 screened human blood ultrafiltrate (a source of the antimicrobial peptides defensins) for small cysteine rich peptides. A 25 amino acid peptide with a mass of 2.7 kDa was found, containing a remarkable eight disulphide bonded cysteine residues. It showed antimicrobial activity against some bacteria and the yeast Saccharomyces cerevisiae . Quantitative reverse transcription-polymerase chain reaction showed predominant expression in liver. The peptide was called LEAP-1 (liver-expressed antimicrobial peptide).3 The cDNA sequence predicted an 84 amino acid pre-propeptide with two cleavage sites. The first predicts cleavage of the N terminal endoplasmic reticulum targeting signal sequence (amino acids 1–24). The second consensus cleavage site for prohormone convertases would yield the central prodomain (amino acids 25−59) plus the 25 amino acid C terminal peptide (also called hepcidin-25; amino acids 60–84). A slightly truncated 20 amino acid peptide was also found (hepcidin 20; amino acids 65–84). Independently, Park and colleagues4 isolated the same cysteine rich peptide from human urine and named it …
Health Manpower: Numbers, Distribution, Quality
Authors: J. MICHAEL MCMILLIN
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 September 1975Health Manpower: Numbers, Distribution, QualityJ. MICHAEL MCMILLIN, M.D.J. MICHAEL MCMILLIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-3-426 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I found Dr. Petersdorf's article (Ann Intern Med 82:694-701, 1975) to be a challenging and candid evaluation of the physician maldistribution problem. However, I feel he neglected several important factors, which led him to make erroneous and potentially dangerous recommendations.The internist, whether he is a subspecialist or not, spends the majority of his time delivering primary care. Thus, unlike the surgeon, in a competitive economic climate he has the option of increasing that portion of his time devoted to primary patient care to maintain his income. In addition, with the exception of procedures such as endoscopy... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. MICHAEL MCMILLIN, M.D.Affiliations: Metabolic Section Minneapolis Veterans Administration Hospital Minneapolis, Minnesota 55417 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1975Volume 83, Issue 3Page: 426-426KeywordsEndoscopyPatientsSub-specialty careSurgeons ePublished: 1 December 2008 Issue Published: 1 September 1975 PDF downloadLoading ...
The mechanism of the length tension ascending limb in heart muscle
Authors: T. IWAZUMI
Journal: Cardiovascular Research (1985)

Journal Article The mechanism of the length tension ascending limb in heart muscle Get access TATSUO IWAZUMI TATSUO IWAZUMI From the Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77550, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 19, Issue 9, September 1985, Page 515, https://doi.org/10.1093/cvr/19.9.515 Published: 01 September 1985
Factitious Anemia Due to Surreptitious Phlebotomy Through A Hickman Catheter
Authors: JOHN PAUL QUINN
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 May 1985Factitious Anemia Due to Surreptitious Phlebotomy Through A Hickman CatheterJOHN PAUL QUINN, M.D., J. PAUL O'KEEFE, M.D.JOHN PAUL QUINN, M.D.Search for more papers by this author, J. PAUL O'KEEFE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-720_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Factitious disorders are not uncommon in tertiary care centers (1, 2). We report a case of a patient with factitious illness characterized by polymicrobial sepsis, which may have been self-induced, and factitious anemia that proved to be due to surreptitious phlebotomy through a Hickman catheter.A 24-year-old nurse was referred to our hospital for evaluation and treatment of a facial abscess that had originated in an abscessed right upper second molar 3 months before admission. On admission she had a temperature of 40° C, swelling and pain in the right maxillary vestibule, and trismus. Two blood cultures...References1. REICHGOTTFRIED PL. Factitious disorders in a teaching hospital. Ann Intern Med. 1983;99:240-7. LinkGoogle Scholar2. ADUANFAUCIDALEHERZBERGWOLFF RADJS. Factitious fever and self-induced infection: a report of 32 cases and review of the literature. Ann Intern Med. 1979;90:230-42. LinkGoogle Scholar3. WEDEL K. A therapeutic confrontation approach to treating patients with factitious illness. Soc Work. 1971;16:69-73. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Loyola University Medical Center Maywood, IL 60153 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySelf-phlebotomy in eating disordersFactitious Hemoptysis and Anemia 1 May 1985Volume 102, Issue 5Page: 720-721KeywordsAbscessesAnemiaBloodCathetersInflammationNursesPhlebotomySepsisTemperature Issue Published: 1 May 1985 PDF DownloadLoading ...
Physician Payment: Fee for Time
Authors: Robert T. Brodell
Journal: JAMA (1994)

To the Editor.  —The recent article regarding a  system by Drs Wachtel and Stein1was certainly thoughtprovoking. Are these authors socialists or communists? What do they think about food? Should all grocers be paid on a fee-for-time system? It should not make a difference what hours they keep, the quality of their service, their location, the type of store, or what they sell! Should there be a cap on their total income just in case a particular grocer might want to improve his family's situation? We wouldn't want him to become fatigued! Productivity should never be rewarded! We wouldn't want there to be any incentive for him to work hard, he should just want to do it!  I can't find any physicians in my community who would support this system. Perhaps we could have nonphysicians act as physicians. Of course, we should pay them at the same rate
The Cervical Venous Hum: A Help and a Hindrance
Authors: Joseph E. Hardison
Journal: New England Journal of Medicine (1975)

The cervical venous hum is a continuous machinery-like noise heard over the internal jugular vein at the base of the neck. It is loudest in diastole, during inspiration and with the patient in the upright position. It may be accentuated by turning of the head away from the side being examined, or by elevation of the chin. It is obliterated by occlusion of the internal jugular vein and the Valsalva maneuver and often if the patient lies down. It occurs more commonly on the right side of the neck, is rarely present only on the left but may occur bilaterally. . . .
Comparison of Fat Intake of American Men and Women
Authors: MEYER FRIEDMAN, RAY H. ROSENMAN
Journal: Circulation (1957)

A detailed dietary survey of 46 women and their husbands belonging to an upper economic stratum was obtained. The caloric and percentage fat intakes of the sexes were almost identical. The data concerning the possible relationship of hormonal, dietary, and socioeconomic factors to the pathogenesis of coronary artery disease are reviewed.
Red Cell Survival in Patients with Mitral Valvular Disease and Mitral Valve Prostheses
Authors: MICHAEL T. H. BRODEUR, ROBERT D. KOLER, ALBERT STARR, HERBERT E. GRISWOLD
Journal: Circulation (1966)

Red cell survival times were measured in patients with mitral valvular disease, mitral ball-valve prostheses, and multiple valve prostheses. Red cell survival was shortened in patients with mitral valvular disease but not in patients who had insertion of a normally functioning mitral prosthesis or after mitral commissurotomy. Mean red cell survival was also reduced in patients who had normal mitral prostheses associated with aortic valvular disease and in patients with a leak around the mitral prosthesis. Mean red cell survival was the same in patients with multiple prostheses and in patients with a single aortic prosthesis. If a leak developed around the mitral prosthesis in patients with multiple prostheses, hemolytic anemia could develop. Renal excretion of iron and iron deficiency were demonstrated in two patients with traumatic hemolytic anemia. The urinary iron loss apparently exceeds the capacity for intestinal absorption, and parenteral iron would seem to be indicated for replacement.
ANTIBODY PRODUCTION BY CELLS IN TISSUE CULTURE
Authors: Claude Hannoun, Alain E. Bussard
Journal: The Journal of Experimental Medicine (1966)

An organ culture technique was used to investigate the migration and the morphological evolution of lymphocytes from lymphopoietic tissues. This evolution was compared with the behavior of cells extracted from the tissue and kept in nutritive medium in vitro. It was found that cells were continuously migrating from the fragments of lymph nodes or spleen, and were attaching to the glass. They spread on glass, their protoplasm enlarged and their nucleus became clearer. The evolution towards blastoid cells was identical with that described under artificial stimulation by PHA for example. Cytological identification of the cells actively engaged in antibody synthesis (as detected by local hemolysis in gum) at the time of staining, showed that several distinct cellular types were active, including plasma cells and macrophagelike cells. It is assumed that the stimulated lymphocytes, after spontaneous migration from the tissue are able to evolve into an "immunoblast" stage and then, eventually after fixation upon a physical support, to initiate antibody synthesis.
Changes in Plasma Mass-Spectral Profile in Course of Treatment of Non-small Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Authors: Chiara Lazzari, Anna Spreafico, Angela Bachi, Heinrich Roder, Irene Floriani, Daniela Garavaglia, Angela Cattaneo, Julia Grigorieva, Maria Grazia Viganò, Cristina Sorlini, Domenico Ghio, Maxim Tsypin, Alessandra Bulotta, Luca Bergamaschi, Vanesa Gregorc
Journal: Journal of Thoracic Oncology (2011)
Evidence for the involvement of two different MHC class II regions in susceptibility or protection in allergic bronchopulmonary aspergillosis
Authors: Bela Chauhan, Louis Santiago, Patricia S. Hutcheson, Howard J. Schwartz, Edward Spitznagel, Mario Castro, Raymond G. Slavin, Clifford J. Bellone
Journal: Journal of Allergy and Clinical Immunology (2000)
Beneficial effects of iloprost in the stunned canine myocardium.
Authors: N E Farber, G M Pieper, J P Thomas, G J Gross
Journal: Circulation Research (1988)

The effect of the prostacyclin-mimetic, iloprost, on the reversibly damaged ("stunned") myocardium was studied in barbital-anesthetized, open-chest dogs subjected to 15 minutes of coronary artery occlusion and 3 hours of reperfusion. Regional myocardial segment shortening (%SS) was measured in the subendocardium of nonischemic and ischemic-reperfused areas by sonomicrometry. Iloprost was infused for 30 minutes beginning 15 minutes prior to occlusion (0.05 microgram/kg/min, ILO-LOW, or 0.1 microgram/kg/min, ILO-HIGH) or immediately prior to reperfusion (0.1 microgram/kg/min, ILO-REP). %SS in the ischemic-reperfused region recovered to 3% of pretreatment values in the control (saline-treated) group by 3 hours of reperfusion. In contrast, %SS in the iloprost-treated groups was significantly enhanced versus the control group at all times of reperfusion. At 3 hours of reperfusion, %SS recovered to 43% (ILO-LOW), 58% (ILO-HIGH), and 35% (ILO-REP) of pretreatment values. The beneficial effect on functional recovery was significantly greater when iloprost was administered before occlusion versus immediately prior to reperfusion. Thus, part of the salutory effects of iloprost appear to occur prior to and/or during ischemia. Iloprost did not improve collateral blood flow to the ischemic region or myocardial high energy phosphate content at 3 hours of reperfusion. While iloprost significantly decreased mean arterial pressure during ischemia and early reperfusion, the hypotensive action did not appear to play a role in the amelioration of postischemic dysfunction, as preocclusion treatment with an equihypotensive dose of sodium nitroprusside produced no significant effect on postischemic recovery beyond 5 minutes of reperfusion. Results of in vitro experiments indicated that iloprost had no effect on the xanthine oxidase free-radical generating system including lipid peroxidation. However, iloprost decreased the neutrophil-derived superoxide burst after chemotactic stimulation. This beneficial action may, in part, explain the efficacy of iloprost in enhancing postischemic function of the stunned myocardium.
Hispanic Health: Time for Data, Time for Action
Authors: Antonia C. Novello
Journal: JAMA (1991)

It is the nature of health statistics to remind us of who we are. Be it information on morbidity, disability, or mortality, the power of health-related data lies in its unblinking capacity to reflect the currents of daily life and their roots in common origins and social ties. It is not surprising, therefore, that the analysis of health data is often conducted in terms of broad perceptions of ethnicity and race. This issue ofThe Journalbreaks new ground in addressing the health issues of Hispanic communities in the United States. Currently the second largest minority group in the United States, the 20 million Hispanics represent an estimated 8.2% of the total population reported to the US Census Bureau in 1989. If current trends continue, Hispanics will represent the largest minority population in the United States by the early 21st century. If nothing else, the collection of articles in this
Otolaryngology: A Textbook
Authors: Robert W. Cantrell
Journal: JAMA (1977)

For more than a decade, the standard textbook of otolaryngology for medical students, residents, and specialists has been<i>Fundamentals of Otolaryngology</i>by Boies, Hilger, and Priest or Otolaryngology by DeWeese and Saunders. Now a new textbook aimed at this same group is offered. Written primarily by physicians in the private practice of otolaryngology, the text is concise, lucid, and well organized. The field of otolaryngology is represented as it is practiced today: a major, regional specialty that covers general otolaryngology, head and neck surgery, allergy, and audiology. Not quite as much emphasis is placed on facial plastic surgery as some otolaryngologists would like, but this is the only topic that is slighted. Many very practical charts are offered that summarize the findings of a particular problem, eg, facial nerve paralysis (to localize the lesion), a summary of vestibular diseases, and many more small but exceedingly helpful charts that are easily
Improvement in Amyloidosis
Authors: MCDONALD K. HORNE
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 August 1975Improvement in AmyloidosisMCDONALD K. HORNE III, CAPT, USAF, MCMCDONALD K. HORNE III, CAPT, USAF, MCSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-2-281 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent paper by Cohen, Lessin, Hallal, et al (1) describing the remarkable response of a patient with renal amyloidosis to chemotherapy has prompted me to report a similar case seen through the past four years at this institution.A 55-year-old white man, presented in April 1971 complaining of abdominal distention, weight loss, and chest pain relieved by antacids. He had previously been in good health except for a benign right renal mass, which had been removed by nephrectomy in 1953. At examination he had hepatomegaly (22-cm liver span), splenomegaly (palpable 10-cm below the costal margin), and...References1. COHENLESSINHALLAL HLJ: Resolution of primary amyloidosis during chemotherapy. Ann Intern Med 82:466-473, 1975 LinkGoogle Scholar2. JONESHILTONTIGHE NPJ: Treatment of "primary" renal amyloidosis with melphalan. Lancet 2:616-619, 1972 CrossrefMedlineGoogle Scholar3. KYLEPIERREBAYRD RRE: Primary amyloidosis and acute leukemia associated with melphalan therapy. Blood 44: 333-337, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnosis and Therapy of Immunoglobulin Light Chain Amyloidosis (AL Amyloidosis)Conventional Treatment of AmyloidosisTreatment of immunoglobulin light chain amyloidosisAmyloidosisAmyloidosis: Diagnosis and ManagementBone Marrow Transplantation for Nonmalignant DiseasesProspects for effective treatment of AL amyloidosis?Myeloablative chemotherapy with stem cell rescue for the treatment of primary systemic amyloidosis: a status reportDiagnosis and treatment of primary amyloidosisAmyloidosis: Prognosis and treatmentThe Restrictive CardiomyopathiesResponse of Primary Hepatic Amyloidosis to Melphalan and Prednisone: A Case Report and Review of the LiteraturePrimary Systemic Amyloidosis (AL): Comparison of Melphalan-Prednisone vs. Colchicine Treatment in 101 CasesPrimary systemic amyloidosis. Comparison of melphalan/prednisone versus colchicineAmyloidosis of the AL typeThe Successful Treatment of Primary Amyloidosis with Intermittent Chemotherapy 1 August 1975Volume 83, Issue 2Page: 281-282KeywordsAmyloidosisChemotherapyHepatomegalyIschemiaLiverNephrectomySplenomegalyWeight loss Issue Published: 1 August 1975 PDF downloadLoading ...
Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis
Authors: Jens-Michael Jensen, Stephan Pfeiffer, Magdalena Witt, Matthias Bräutigam, Claudia Neumann, Michael Weichenthal, Thomas Schwarz, Regina Fölster-Holst, Ehrhardt Proksch
Journal: Journal of Allergy and Clinical Immunology (2009)
The Tumor Suppressor p53 Down-Regulates Glucose Transporters <b> <i>GLUT1</i> </b> and <b> <i>GLUT4</i> </b> Gene Expression
Authors: Fabiana Schwartzenberg-Bar-Yoseph, Michal Armoni, Eddy Karnieli
Journal: Cancer Research (2004)

Abstract Tumorigenesis is associated with enhanced cellular glucose uptake and increased metabolism. Because the p53 tumor suppressor is mutated in a large number of cancers, we evaluated whether p53 regulates expression of the GLUT1 and GLUT4 glucose transporter genes. Transient cotransfection of osteosarcoma-derived SaOS-2 cells, rhabdomyosarcoma-derived RD cells, and C2C12 myotubes with GLUT1-P-Luc or GLUT4-P-Luc promoter-reporter constructs and wild-type p53 expression vectors dose dependently decreased both GLUT1 and GLUT4 promoter activity to approximately 50% of their basal levels. PG13-Luc activity, which was used as a positive control for functional p53 expression, was increased up to ∼250-fold by coexpression of wild-type p53. The inhibitory effect of wild-type p53 was greatly reduced or abolished when cells were transfected with p53 with mutations in amino acids 143, 248, or 273. A region spanning −66/+163 bp of the GLUT4 promoter was both necessary and sufficient to mediate the inhibitory effects of p53. Furthermore, in vitro translated p53 protein was found to bind directly to two sequences in that region. p53-DNA binding was completely abolished by excess unlabeled probe but not by nonspecific DNA and was super-shifted by the addition of an anti-p53 antibody. Taken together, our data strongly suggest that wild-type p53 represses GLUT1 and GLUT4 gene transcription in a tissue-specific manner. Mutations within the DNA-binding domain of p53, which are usually associated with malignancy, were found to impair the repressive effect of p53 on transcriptional activity of the GLUT1 and GLUT4 gene promoters, thereby resulting in increased glucose metabolism and cell energy supply. This, in turn, would be predicted to facilitate tumor growth.
Brain-based sex differences in parenting propagate emotion expression
Authors: James E. Swain
Journal: Behavioral and Brain Sciences (2009)

Abstract Parent-infant emotional expressions vary according to parent and infant gender. Such parent-infant interactions critically affect infant development. Neuroimaging research is exploring emotion-related brain function that varies according to gender, and regulates parenting thoughts and behaviors in the early postpartum. Through specific brain functions, parenting serves to program the infant brain for the next generation of sex-specific emotional expression.
645 SERUM CARBONIC ANHYDRASE 9 (CA) IS A VALUABLE BIOMARKER (BM) TO PROFILE PATIENTS WITH HEPATOCELLULAR CARCINOMA (HCC) TREATED WITH SORAFENIB AND PREDICT THEIR OUTCOME
Authors: M.E. Reig, L. Boix, A. Forner, J. Rimola, C. Rodriguez de Lope, J.M. Lopez-Oliva, S. Tremosini, N. Llarch, J.M. Llovet, C. Ayuso, J. Bruix
Journal: Journal of Hepatology (2011)