tbuckley/cabot-search huggingface dataset:
Androgen-deprivation regimen for multiple bone metastases of extramammary Paget disease
Authors: K. Yoneyama, N. Kamada, K. Kinoshita, T. Kawashima, M. Otani, H. Endo, H. Shinkai, A. Utani
Journal: British Journal of Dermatology (2005)

Journal Article Androgen‐deprivation regimen for multiple bone metastases of extramammary Paget disease Get access K. Yoneyama, K. Yoneyama Department of Dermatology, School of Medicine, Chiba University, Japan Department of Dermatology, School of Medicine, Kyoto University, 54 Kawahara‐cho, Shogoin, Sakyo‐ku, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar N. Kamada, N. Kamada Department of Dermatology, School of Medicine, Chiba University, Japan Department of Dermatology, School of Medicine, Kyoto University, 54 Kawahara‐cho, Shogoin, Sakyo‐ku, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Kinoshita, K. Kinoshita Department of Dermatology, School of Medicine, Chiba University, Japan Department of Dermatology, School of Medicine, Kyoto University, 54 Kawahara‐cho, Shogoin, Sakyo‐ku, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Kawashima, T. Kawashima Department of Dermatology, School of Medicine, Chiba University, Japan Department of Dermatology, School of Medicine, Kyoto University, 54 Kawahara‐cho, Shogoin, Sakyo‐ku, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Otani, M. Otani Department of Dermatology, School of Medicine, Chiba University, Japan Department of Dermatology, School of Medicine, Kyoto University, 54 Kawahara‐cho, Shogoin, Sakyo‐ku, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Endo, H. Endo Department of Dermatology, School of Medicine, Chiba University, Japan Department of Dermatology, School of Medicine, Kyoto University, 54 Kawahara‐cho, Shogoin, Sakyo‐ku, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Shinkai, H. Shinkai Department of Dermatology, School of Medicine, Chiba University, Japan Department of Dermatology, School of Medicine, Kyoto University, 54 Kawahara‐cho, Shogoin, Sakyo‐ku, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar A. Utani A. Utani Department of Dermatology, School of Medicine, Chiba University, Japan Department of Dermatology, School of Medicine, Kyoto University, 54 Kawahara‐cho, Shogoin, Sakyo‐ku, Kyoto 606‐8507, Japan Atsushi Utani. E‐mail: utani@kuhp.kyoto‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 4, 1 October 2005, Pages 853–855, https://doi.org/10.1111/j.1365-2133.2005.06865.x Published: 01 October 2005
Randomised trial of intravenous high dose metoclopramide and intramuscular chlorpromazine in controlling nausea and vomiting induced by cytotoxic drugs.
Authors: D Cunningham, M Soukop, N L Gilchrist, G J Forrest, A Hepplestone, I T Calder, C S McArdle, A W Hutcheon, S B Kaye
Journal: BMJ (1985)
Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Cristina Basso, Gaetano Thiene, Domenico Corrado, Annalisa Angelini, Andrea Nava, Marialuisa Valente
Journal: Circulation (1996)

Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a frequent cause of sudden death in young individuals and athletes. Although familial occurrence has been documented and a gene defect was recently localized on chromosome 14q23-q24 the etiopathogenesis of the disease is still obscure. Methods and Results A pathological study was conducted in 30 hearts with ARVC (age range, 15 to 65 years; mean, 28 years). In the 27 autopsy cases, the mode of death was sudden in 24 and congestive heart failure in 3. ECG, available in 19 cases, showed inverted T waves in the right precordial leads in 15 cases (79%) and ventricular arrhythmias in 15 (79%). Right ventricular aneurysms were present in 15 hearts (50%) and located in the inferior wall in 12. Left ventricle and ventricular septum were involved in 14 (47%) and 6 (20%) cases, respectively. Scattered foci of lymphocytes with myocardial death were observed in 20 cases (67%). Electron microscopy studies, although confirming the myocardial death and lymphocyte infiltrates, did not show any specific ultrastructural substrate. Two pathological patterns, fatty (40%) and fibrofatty (60%), were identified. The fibrofatty pattern was associated with a thinner right ventricular wall ( P &lt;.0001) and a higher occurrence of focal myocarditis ( P &lt;.001). In sections of right ventricular free wall with maximal fatty infiltration, the mean percentage area of fatty tissue was 35.9±11.1% in control versus 80.4±9.6% in the ARVC, fatty variety ( P &lt;.00001). Involvement of the left ventricle and/or ventricular septum, right ventricular aneurysms, and inflammation were found almost exclusively in the fibrofatty variety. Conclusions In the fibrofatty variety of ARVC, the myocardial atrophy appears to be the consequence of acquired injury (myocyte death) and repair (fibrofatty replacement), mediated by patchy myocarditis. Whether the inflammation is a primary event or a reaction to spontaneous cell death remains unclear.
Praziquantel Reverses Pulmonary Hypertension and Vascular Remodeling in Murine Schistosomiasis
Authors: Alexi Crosby, Frances M. Jones, Ewa Kolosionek, Mark Southwood, Ian Purvis, Elaine Soon, Ghazwan Butrous, David W. Dunne, Nicholas W. Morrell
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Schistosomiasis is the most common worldwide cause of pulmonary arterial hypertension. The anti-schistosome drug praziquantel has been shown to reverse the liver fibrosis associated with Schistosoma mansoni in mice.
Highly Sensitive Detection of EGFR T790M Mutation Using Colony Hybridization Predicts Favorable Prognosis of Patients with Lung Cancer Harboring Activating EGFR Mutation
Authors: Yoshihiko Fujita, Kenichi Suda, Hideharu Kimura, Kazuko Matsumoto, Tokuzo Arao, Tomoyuki Nagai, Nagahiro Saijo, Yasushi Yatabe, Tetsuya Mitsudomi, Kazuto Nishio
Journal: Journal of Thoracic Oncology (2012)
STUDIES OF THE GENERALIZED SHWARTZMAN REACTION PRODUCED BY DIET
Authors: Donald G. McKay, Ting-Chao Wong
Journal: The Journal of Experimental Medicine (1962)

A 4-fold reduction in the death rate of pregnant rats subjected to a diet capable of inducing the generalized Shwartzman reaction was obtained by the administration of oral absorbable and non-absorbable antibiotics. The possible mechanisms of this partial protection have been discussed.
Simultaneous Chest Radiographic Findings of Hampton's Hump, Westermark's Sign, and Vascular Redistribution in Pulmonary Embolism
Authors: PING LU, BENNETT B. CHIN
Journal: Clinical Nuclear Medicine (1998)

Chest radiographic findings in patients with pulmonary embolism are highly variable and may be nonspecific. The Westermark's sign (focal oligemia) has been described as a highly specific sign that rapidly disappears after treatment. The Hampton's hump due to pulmonary infarct is more common, but may be confused with pulmonary infiltrate from pneumonia. Pulmonary vascular redistribution is also relatively uncommon. We report a unique case in which all of these findings were initially present but only recognized in retrospect after correlation with ventilation-perfusion scintigraphy and follow-up chest radiograph. Infiltrates, and increased or decreased lung markings may all be due to pulmonary embolism and its sequelae. Ventilation-perfusion scintigraphy may clarify the etiology of these abnormalities and is not contraindicated in patients with markedly abnormal chest radiographs.
Bystander cardiopulmonary resuscitation. Is ventilation necessary?
Authors: R A Berg, K B Kern, A B Sanders, C W Otto, R W Hilwig, G A Ewy
Journal: Circulation (1993)

BACKGROUND Prompt initiation of bystander cardiopulmonary resuscitation (CPR) improves survival. Basic life support with mouth-to-mouth ventilation and chest compressions is intimidating, difficult to remember, and difficult to perform. Chest compressions alone can be easily taught, easily remembered, easily performed, adequately taught by dispatcher-delivered telephone instruction, and more readily accepted by the public. The principal objective of this study was to evaluate the need for ventilation during CPR in a clinically relevant swine model of prehospital witnessed cardiac arrest. METHODS AND RESULTS Thirty seconds after ventricular fibrillation, swine were randomly assigned to 12 minutes of chest compressions plus mechanical ventilation (group A), chest compressions only (group B), or no CPR (group C). Standard advanced cardiac life support was then provided. Animals successfully resuscitated were supported for 2 hours in an intensive care setting, and then observed for 24 hours. All 16 swine in groups A and B were successfully resuscitated and neurologically normal at 24 hours, whereas only 2 of 8 group C animals survived for 24 hours (P &lt; .001, Fisher's exact test). One of the 2 group C survivors was comatose and unresponsive. CONCLUSIONS In this swine model of witnessed prehospital cardiac arrest, the survival and neurological outcome data establish that prompt initiation of chest compressions alone appears to be as effective as chest compressions plus ventilation and that both techniques of bystander CPR markedly improve outcome compared with no bystander CPR.
Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations
Authors: Tadayuki Akagi, Lee-Yung Shih, Motohiro Kato, Norihiko Kawamata, Go Yamamoto, Masashi Sanada, Ryoko Okamoto, Carl W. Miller, Der-Cherng Liang, Seishi Ogawa, H. Phillip Koeffler
Journal: Blood (2008)
Neutrophil zinc levels in psoriasis and seborrhoeic dermatitis
Authors: R.S.C. LEUNG, A.J. TURNBULL, J.A. TAYLOR, R. RUSSELL-JONES, R.P.H. THOMPSON
Journal: British Journal of Dermatology (1990)

Journal Article Neutrophil zinc levels in psoriasis and seborrhoeic dermatitis Get access R.S.C. LEUNG, R.S.C. LEUNG St John's Hospital for Diseases of the Skin Search for other works by this author on: Oxford Academic Google Scholar A.J. TURNBULL, A.J. TURNBULL Gastrointestinal Laboratory, Rayne Institute, St Thomas's Hospital, London SE17EH, U.K. Dr A.J.Turnbull Search for other works by this author on: Oxford Academic Google Scholar J.A. TAYLOR, J.A. TAYLOR Gastrointestinal Laboratory, Rayne Institute, St Thomas's Hospital, London SE17EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. RUSSELL‐JONES, R. RUSSELL‐JONES St John's Hospital for Diseases of the Skin Search for other works by this author on: Oxford Academic Google Scholar R.P.H. THOMPSON R.P.H. THOMPSON Gastrointestinal Laboratory, Rayne Institute, St Thomas's Hospital, London SE17EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 123, Issue 3, 1 September 1990, Pages 319–323, https://doi.org/10.1111/j.1365-2133.1990.tb06291.x Published: 01 September 1990
Conversations, observations, and exclamation
Authors: G. Levy
Journal: BMJ (2001)

About three and a half years ago, I started to feel unwell. The following day—a Sunday—I took myself off to see the emergency GP. She suggested, rather forcibly, that I should go straight to hospital. From this point I have developed an interesting relationship with some of the doctors I have seen. The majority of the two dozen or so doctors have been professional, supportive, and amicable. My GPs have, without fail, been exemplary.

There have, however, been conversations with other doctors that provide alarming insights into the self perception of some members of the medical profession. As an ethnographer (a sort of psychologist) I relate some of the conversations.

The duty consultant (after a very brief examination) on being first referred as an emergency: “Young man, I can find no evidence whatsoever of what you are saying is so. I don't know why you were sent here. Go home.” 

> As you have probably guessed, you have multiple sclerosis 

Two days later my GP came to see me—I was now …
Ventriculographic Patterns and Hemodynamics in Primary Myocardial Disease
Authors: THOMAS H. KREULEN, RICHARD GORLIN, MICHAEL V. HERMAN
Journal: Circulation (1973)

Thirty-four patients with primary myocardial disease were studied and classified into three distinct types based on their left ventriculogram. Each had unique ventriculographic characteristics and findings. Type I are patients with a normal contraction pattern and an elevated left ventricular end-diastolic pressure. Type II A are patients with a hypertrophic pattern without obstruction to outflow while type II B patients have outflow obstruction. Type III A are patients with generalized hypokinesis. Type III B have a similar contraction pattern but in addition show asynergy. Analysis of the right ventriculogram in seven patients showed changes paralleling those seen in the left ventricle, including asynergic patterns of contraction. The electrocardiogram and chest roentgenogram were found to be sensitive but nonspecific indicators of disease. The short-term prognosis was excellent with type I and poor with type III while type II patients had an intermediate prognosis.
The HEP@NET study: an internet-based registry examining the efficacy of heparin coating in patients undergoing coronary stent implantation
Authors: Roxana Mehran, C. Lotan, I. Kranjec, E. Holmer, K. Haase, E. Camenzind, M. Zelizko, L. Maillard, R. Seabra-Gomes, M.G. Vandormael, A.J. Lansky, G. Dangas, G.W. Stone, Dale T. Ashby, M.B. Leon
Journal: Journal of the American College of Cardiology (2002)
Amplification of T cell blastogenic responses in healthy individuals and patients with acquired immunodeficiency syndrome.
Authors: P E Harris, K Strba-Cechova, P Rubinstein, D Mann, D W King, N Suciu-Foca
Journal: Journal of Clinical Investigation (1990)

Human immunodeficiency virus (HIV) infection is associated with a profound impairment of T cell function. Hence, enhancement of T cell reactivity to viral and bacterial antigens is important in the treatment of patients with AIDS. To develop tools for amplifying T cell reactivity, we have immunized mice with human helper T cell clones and selected monoclonal antibodies (MAbs) that enhance in vitro blastogenic responses. MAb NDA5, which recognizes the leukocyte common antigen CD45, amplifies human T cell responses to mitogens and soluble antigens including HIV-1 glycoprotein (gp)-120 and peptides derived from the HIV-1 gp-120 sequence. In the presence of MAb NDA5, peripheral blood mononuclear cells (PBMC) from healthy, HIV-1-seronegative individual displayed augmented blastogenic responses to HIV-1 gp-120 and to HIV-1 gp-120 synthetic peptides. In vitro memory responses to various vaccines and to alloantigens were also enhanced in cultures with MAb. Similarly, the response of PBMC from AIDS patients to pokeweed mitogen, HIV-1 gp-120, and tetanus toxoid was enhanced with MAb NDA5. The finding that the in vitro immune response of patients with AIDS can be amplified with MAb NDA5, suggests that the in vivo immune response of immunodeficient individuals can also be enhanced.
Identification of DNA Methylation Changes in Newborns Related to Maternal Smoking during Pregnancy
Authors: Christina A. Markunas, Zongli Xu, Sophia Harlid, Paul A. Wade, Rolv T. Lie, Jack A. Taylor, Allen J. Wilcox
Journal: Environmental Health Perspectives (2014)

Maternal smoking during pregnancy is associated with significant infant morbidity and mortality, and may influence later disease risk. One mechanism by which smoking (and other environmental factors) might have long-lasting effects is through epigenetic modifications such as DNA methylation.We conducted an epigenome-wide association study (EWAS) investigating alterations in DNA methylation in infants exposed in utero to maternal tobacco smoke, using the Norway Facial Clefts Study.The Illumina HumanMethylation450 BeadChip was used to assess DNA methylation in whole blood from 889 infants shortly after delivery. Of 889 mothers, 287 reported smoking-twice as many smokers as in any previous EWAS of maternal smoking. CpG sites related to maternal smoking during the first trimester were identified using robust linear regression.We identified 185 CpGs with altered methylation in infants of smokers at genome-wide significance (q-value < 0.05; mean Δβ = ± 2%). These correspond to 110 gene regions, of which 7 have been previously reported and 10 are newly confirmed using publicly available results. Among these 10, the most noteworthy are FRMD4A, ATP9A, GALNT2, and MEG3, implicated in processes related to nicotine dependence, smoking cessation, and placental and embryonic development.Our study identified 10 genes with newly established links to maternal smoking. Further, we note differences between smoking-related methylation changes in newborns and adults, suggesting possible distinct effects of direct versus indirect tobacco smoke exposure as well as potential differences due to age. Further work would be needed to determine whether these small changes in DNA methylation are biologically or clinically relevant. The methylation changes identified in newborns may mediate the association between in utero maternal smoking exposure and later health outcomes.
Response to Letter Regarding Article, “Physician Alerts to Prevent Symptomatic Venous Thromboembolism in Hospitalized Patients”
Authors: Gregory Piazza, Erin J. Rosenbaum, Samuel Z. Goldhaber, William Pendergast, Joseph O. Jacobson, Robert C. Pendleton, Gordon D. McLaren, C. Gregory Elliott, Scott M. Stevens, William F. Patton, Ousama Dabbagh, Marilyn D. Paterno, Elaine Catapane, Zhongzhen Li
Journal: Circulation (2009)

Symptomatic Venous Thromboembolism in Hospitalized Patients"We thank Dr Spyropoulos for his comments on our article. 1pper-extremity deep vein thrombosis (UEDVT) has become more common over the past several decades. 2 This phenomenon is due to the increasing use of indwelling central venous catheters, pacemakers, and defibrillators.We advocate studying UEDVT in venous thromboprophylaxis trials.In a study of 483 outpatients presenting with objectively confirmed acute DVT, 69 had UEDVT. 3More than half of these patients with UEDVT had a history of recent prior hospitalization.An analysis of a subset of these patients who had been hospitalized within the 3 months prior to UEDVT diagnosis demonstrated that fewer than half received any thromboprophylaxis.Importantly, rates of mortality, recurrent venous thromboembolism, and major bleeding at 30 days, 6 months, and 1 year were comparable between UEDVT patients and those with lower extremity DVT.In the Registro Informatizado de la Enfermedad Tromboembólica (RIETE) Registry, investigators observed similar findings with no significant difference in 3-month outcome for bleeding or recurrent venous thromboembolism when comparing 512 UEDVT patients with 11 052 patients who had lower extremity DVT. 4 For too long, UEDVT has been treated like a neglected orphan within the field of venous thromboembolism.We encourage investigators to include UEDVT patients when they plan and execute their clinical trials.
Effect of Protamine on Alimentary Lipemia
Authors: ALLAN J. DAY, GWENDOLINE K. WILKINSON, HUGH R. GILMORE, COLIN J. SCHWARTZ, J. A. Peters
Journal: Circulation (1957)

The effect of protamine on the serum lipids during alimentary lipemia was investigated in normal male students and this effect was compared with that in atherosclerotic and in nonatherosclerotic men of the same age group. In the student group protamine produced a highly significant increase in the total fatty acid level, whereas in the 2 older groups no significant change occurred. These results were interpreted as demonstrating that circulating heparin exerts a physiologic effect on fat turnover in the young individual, an effect that is reduced with aging. It is suggested that the lowered fat tolerance known to occur with aging is the result of deficiency of circulating heparin.
Handling of tracer bicarbonate by the liver. The relative impermeability of hepatocyte cell membranes to the ionic species.
Authors: A J Schwab, C A Goresky, C P Rose
Journal: Circulation Research (1989)

The multiple indicator dilution technique was used to study transfer of labeled HCO3- across the hepatocyte membrane in the anesthetized mongrel dog. A bolus of H[14C]O3-, 51Cr-labeled erythrocytes, [36Cl-] and/or [3H]sucrose, and [3H]OH was injected through a catheter in the portal vein, and timed anaerobic blood samples were obtained from a catheter in the hepatic vein. Experiments were carried out in untreated controls and after intravenous infusion of acetazolamide (100 mg/kg). In the controls, the H[14C]O3- curve was very similar to the [3H]OH curve. The dilution curves were all linear transformations of each other, indicating that HCO3-, as had previously been shown for the other diffusible tracers, undergoes delayed-wave flow-limited distribution. The distribution space for H[14C]O3- in the control situation includes the blood plasma and interstitial spaces, the erythrocyte interior modified by a Donnan equilibrium, and the available liver cellular space. The calculated HCO3- concentration in the liver cells was somewhat lower than that in the plasma space; the difference implied a cellular pH lower than that of plasma by approximately 0.08 pH units. When the carbonic anhydrases were inhibited with acetazolamide, the dilution curve for H[14C]O3- changed radically, approaching that for [36Cl-], which does not enter the liver cells. The change indicates that although HCO3-, like Cl-, is rapidly exchanged between plasma and erythrocytes, it also does not readily penetrate hepatocytes unless previously transformed to carbon dioxide by the carbonic anhydrases.
Subcellular Localization of Sigma-2 Receptors in Breast Cancer Cells Using Two-Photon and Confocal Microscopy
Authors: Chenbo Zeng, Suwanna Vangveravong, Jinbin Xu, Katherine C. Chang, Richard S. Hotchkiss, Kenneth T. Wheeler, Duanwen Shen, Zhi-Ping Zhuang, Hank F. Kung, Robert H. Mach
Journal: Cancer Research (2007)

Abstract Sigma-2 receptor agonists have been shown to induce cell death via caspase-dependent and caspase-independent pathways. Unfortunately, there is little information regarding the molecular function of sigma-2 receptors that can explain these results. In this study, two fluorescent probes, SW107 and K05-138, were used to study the subcellular localization of sigma-2 receptors by two-photon and confocal microscopy. The results indicate that sigma-2 receptors colocalize with fluorescent markers of mitochondria, lysosomes, endoplasmic reticulum, and the plasma membrane in both EMT-6 mouse and MDA-MB-435 human breast cancer cells. The fluorescent probe, K05-138, was internalized rapidly, reaching a plateau of fluorescent intensity at 5 min. The internalization of K05-138 was reduced ∼40% by phenylarsine oxide, an inhibitor of endocytosis. These data suggest that sigma-2 ligands are internalized, in part, by an endocytotic pathway. The localization of sigma-2 receptors in several organelles known to have a role in both caspase-dependent and caspase-independent pathways of cell death supports the conclusions of previous studies suggesting that sigma-2 receptor ligands should be evaluated as potential cancer chemotherapeutic agents. [Cancer Res 2007;67(14):6708–16]