Central Nervous System Involvement in the Acquired Immunodeficiency Syndrome (AIDS)
Authors: James W. Dilley
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 September 1988Central Nervous System Involvement in the Acquired Immunodeficiency Syndrome (AIDS)James W. Dilley, MD, Alicia Boccellari, PhD, David Heilbron, PhDJames W. Dilley, MDSearch for more papers by this author, Alicia Boccellari, PhDSearch for more papers by this author, David Heilbron, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-6-508 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Grant and associates (1) have described a trend of progressive neuropsychologic impairment in a small number of patients (n= 55) spread across four groups: those with the acquired immunodeficiency syndrome (AIDS) (n= 15); those with the AIDS-related complex (n= 13); those who are positive for the human immunodeficiency virus (HIV) (n= 16); and those who are HIV-negative (n= 11). Because the incidence of neuropsychologic impairment among persons with AIDS (2) is a well-known and well-accepted clinical phenomenon, the most significant finding in this report was the relatively high percentage of impairment found...References1. GrantAtkinsonHesselink IJJ. Evidence for early central nervous system involvement in the acquired immunodeficiency syndrome (AIDS) and other human immunodeficiency virus (HIV) infections. Ann Intern Med. 1987;107:828-36. LinkGoogle Scholar2. NaviaJordanPrice BBR. The AIDS dementia complex: I. Clinical features. Ann Neurol. 1986;19:517-24. CrossrefMedlineGoogle Scholar3. Lezak M. Neuropsychological Assessment. 2nd ed. New York: Ox ford University Press; 1983. Google Scholar4. RussellNeuringerGoldstein ECG. Assessment of Brain Damage. A Neuropsychological Key Approach. New York: Wiley-Interscience; 1970. Google Scholar5. GronwallWrightson DP. Cumulative effect of concussion. Lancet. 1975;995-6. CrossrefMedlineGoogle Scholar1. GrantAtkinsonHesselink IJJ. Evidence for early central nervous system involvement in the acquired immunodeficiency syndrome (AIDS) and other human immunodeficiency virus (HIV) infections. Ann Intern Med. 1987;107:828-36. LinkGoogle Scholar2. HeatonGrantMatthews RIC. Differences in neuropsychological test performance associated with age, education, and sex. In: Grant I, Adams KM, eds. Neuropsychological Assessment of Neuropsychiatric Disorders. New York: Oxford University Press. 1986:100-20. Google Scholar3. ReitanDavison RL eds. Clinical Neuropsychology: Current Status and Applications. Washington, D.C.: V. M. Winston and Sons; 1974. Google Scholar4. AtkinsonGrantKennedyRichmanSpectorMcCutchan JICDSJ. Prevalence of psychiatric disorders among men infected with human immunodeficiency virus: a controlled study. Arch Gen Psychiatry. 1988: [In press]. CrossrefMedlineGoogle Scholar5. BarkerLoewensteinChang WDJ. Effects of physostigmine on cerebral glucose metabolism (CMRglc) measured by 18FDG/PET studies in normals. Society for Neuroscience: 17th Annual Meeting, New Orleans, November 16-21, 1987. Google Scholar6. McArthurCohenFarzedegan JBH. Cerebrospinal fluid abnormalities in homosexual men with and without neuropsychiatric findings. Ann Neurol. 1988;23(Suppl):34-7. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco General Hospital University of California San Francisco, CA 94143-0884 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeuropsychological Deficits In HIV-1 seropositive and seronegative intravenous drug users (IVDUs): A follow-up studyNeuropsychological function in asymptomatic HIV-1 infection: Methodological issuesNeuropsychological deficits in HIV-1 seropositive and seronegative intravenous drug usersRegional brain atrophy in HIV-1 infection: association with specific neuropsychological test performanceNeurological complications of infection with human immunodeficiency virus type 1 15 September 1988Volume 109, Issue 6Page: 508-510KeywordsAIDSAIDS related complexCentral nervous systemDrug abuseHIV Issue Published: 15 September 1988 PDF downloadLoading ...