Fluphenazine and Inappropriate Secretion of Antidiuretic Hormone
Authors: JORGE S. ZUNIGA
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 November 1975Fluphenazine and Inappropriate Secretion of Antidiuretic HormoneJORGE S. ZUNIGA, M.D., TOBY HAZAN, M.D.JORGE S. ZUNIGA, M.D.Search for more papers by this author, TOBY HAZAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-735_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent case of inappropriate secretion of antidiuretic hormone (ADH) secondary to the use of fluphenazine was reported in the June issue. The patient that was reported suffered two convulsive seizures (1).Although we have observed a case of inappropriate ADH secretion in one of our patients treated with fluphenazine (2), convulsive seizures can in themselves produce the syndrome "by virtue of an irritable focus that promotes the secretion of the hormone" (3-5). The case reported by Dr. de Rivera does not provide sufficient cause-effect relationship between the use of fluphenazine and inappropriate ADH secretion, particularly when...References References References1. DE RIVERA J: Inappropriate secretion of antidiuretic hormone from fluphenazine therapy. Ann Intern Med 82:811-812, 1975 LinkGoogle Scholar2. SHAW R and LORETTI L: Unpublished Google Scholar3. DILLON R: Handbook of Endocrinology. Philadelphia, Lea and Febiger, 1973, pp. 201-202 Google Scholar4. WELT L, DINGMAN J, and THORN G: in Harrison's Principles of Internal Medicine, 7th ed., edited by WINTROBE MM et al. New York, McGraw Hill, 1974, chapters 84 and 264 Google Scholar5. SCHWARTZ W: in Cecil-Loeb Textbook of Medicine, 14th ed., edited by BEESON PB, MCDERMOTT W. Philadelphia, W. B. Saunders, 1975, p. 1582 Google Scholar1. Welt L: Disorders of fluids and electrolytes, in Harrison's Principles of Internal Medicine, 7th ed., edited by Wintrobe MM et al. New York, McGraw Hill, 1974, p. 1347 Google Scholar2. Adams R: The convulsive state. See Reference 1, p. 135 Google Scholar3. Dubovsky S, Grabon S, and Berl T: Syndrome of inappropriate secretion of antidiuretic hormone with exacerbated psychosis. Ann Intern Med 79:551-554, 1973 LinkGoogle Scholar1. Hobson J and English J: Self-induced water intoxication. Ann Intern Med 58:324-332, 1963 LinkGoogle Scholar2. Ajlouni K, Kern M, and Tures J: Thiothixene-induced hyponatremia. Arch lnterm Med 134:1103-1105, 1974 CrossrefMedlineGoogle Scholar3. Luzecky M, Burman K, and Schultz E: The syndrome of inappropriate secretion of antidiuretic hormone associated with amitriptyline administration. South Med J 67:495-497, 1974 CrossrefMedlineGoogle Scholar4. Dyball R: The effect of drugs on the release of vasopressin. Br J Pharmacol Chemother 33:329-341, 1968 CrossrefMedlineGoogle Scholar5. Kimura T, Matsui K, and Sato T: Mechanism of carbamaz-epine (Tegretol) induced antidiuresis: evidence for release of antidiuretic hormone and impaired excretion of a water load. J Clin Endocrinol Metab 38:356-362, 1974 CrossrefMedlineGoogle Scholar6. Maxwell M and Kleeman C: Clinical Disorders of Fluid and Electrolyte Metabolism, 2nd ed., New York, McGraw Hill, 1972, chapter 7 Google Scholar7. Schrier R and Berl T: Non-osmolar factors affecting water excretion. N Engl J Med 292:141-145, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JORGE S. ZUNIGA, M.D.; TOBY HAZAN, M.D.Affiliations: Crises Intervention Center Department of Psychiatry Sinai Hospital of Detroit 6767 West Outer Drive Detroit, Michigan 48235 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySIADH: A Serious Side Effect of Psychotropic DrugsThe Syndrome of Inappropriate Secretion of Antidiuretic Hormone (Siadh): An Overview 1 November 1975Volume 83, Issue 5Page: 735-737KeywordsAntidiuretic hormoneEpileptic seizuresHormones ePublished: 1 December 2008 Issue Published: 1 November 1975 PDF downloadLoading ...