Diagnosis of Hemochromatosis
Authors: Kamyar Kalantar-Zadeh, Friedrich C. Luft
Journal: Annals of Internal Medicine (1999)

Letters17 August 1999Diagnosis of HemochromatosisKamyar Kalantar-Zadeh, MD, MPH and Friedrich C. Luft, MDKamyar Kalantar-Zadeh, MD, MPHUniversity of California, San Francisco; San Francisco, CA 94143 (Kalantar-Zadeh)Humboldt University of Berlin; 13122 Berlin, Germany (Luft)Search for more papers by this author and Friedrich C. Luft, MDUniversity of California, San Francisco; San Francisco, CA 94143 (Kalantar-Zadeh)Humboldt University of Berlin; 13122 Berlin, Germany (Luft)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-4-199908170-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We take issue with the hemochromatosis laboratory criteria by Powell and colleagues (1). The authors concluded that a serum transferrin saturation greater than 45%, a serum ferritin level greater than 200 µg/L in premenopausal women, and a serum ferritin level greater than 300 µg/L in men and postmenopausal women are indicators for primary iron overload. Although the authors explain that elevated serum ferritin levels may be due to inflammation, infection, or cancer and suggest that acute-phase reactants be obtained to exclude these entities, they ignore the fact that in patients with end-stage renal disease (ESRD), the relation ...References1. Powell LW, Georg K, McDonnel SM, Kowdley KV. Diagnosis of hemochromatosis. Ann Intern Med. 1998;129:925-31. LinkGoogle Scholar2. Kalantar-Zadeh K, Wünsch PH, Fink H, Höffken B, Kleiner M, Luft FC. Diagnosis of iron deficiency anemia in renal failure patients during post erythropoietin era. Am J Kid Dis. 1995;26:292-9. CrossrefMedlineGoogle Scholar3. Barany P, Eriksson LC, Hultcrantz R, Pettersson E, Bergstrom J. Serum ferritin and tissue iron in anemic dialysis patient. Min Electrolyte Metab. 1997;23:273-6. MedlineGoogle Scholar4. NKF-DOQI clinical practice guidelines for the treatment of anemia of chronic renal failure. National Kidney Foundation-Dialysis Outcomes Quality Initiative. Am J Kid Dis. 1997; 30(4 Suppl 3):S192-240. Google Scholar5. Kalantar-Zadeh K, Kleiner M, Dunne E, Nelson M, Ahern K, Koslowe R, et al . Total iron binding capacity-estimated transferrin concentrations in dialysis patients correlate with the subjective global assessment of nutrition. Am J Kid Dis. 1998;31:263-72. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Kamyar Kalantar-Zadeh, MD, MPH; Friedrich C. Luft, MDAffiliations: University of California, San Francisco; San Francisco, CA 94143 (Kalantar-Zadeh)Humboldt University of Berlin; 13122 Berlin, Germany (Luft) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDiagnosis of Hemochromatosis Lawrie W. Powell , D. Keith George , Sharon M. McDonnell , and Kris V. Kowdley Diagnosis of Hemochromatosis Lawrie W. Powell , D. Keith George , and Sharon McDonnell Metrics Cited byEpidemiology of Dialysis Patients and Heart Failure PatientsA low serum iron level is a predictor of poor outcome in hemodialysis patientsSerum ferritin is a marker of morbidity and mortality in hemodialysis patients 17 August 1999Volume 131, Issue 4Page: 311KeywordsAcute phase proteinsHemochromatosisInflammationIron deficiencyMalnutritionMedical dialysisNutritionRenal failureResearch laboratoriesSerum ferritin levels ePublished: 15 August 2000 Issue Published: 17 August 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...