tbuckley/cabot-search huggingface dataset:
Neutrophil/Lymphocyte Ratio May Predict in-Hospital Clinical Events in Patients with Aortic Dissection
Authors: Süleyman Karakoyun, Mustafa Ozan Gürsoy, Lütfi Öcal, Macit Kalçık, Mahmut Yesin, Emrah Erdoğan, Şeyhmus Külahçıoğlu, Ruken Bengi Bakal, Cengiz Köksal, Mustafa Yıldız, Mehmet Özkan
Journal: Journal of the American College of Cardiology (2013)
THE EXCRETION OF CYANOL, AZOFUCHSIN I AND WATER BY THE KIDNEYS OF RABBITS
Authors: William E. Ehrich, George M. Bartol, Richard E. Wolf
Journal: The Journal of Experimental Medicine (1938)

1. The excretion of water has been studied in a large number of experiments on rabbits. After the ingestion of 100 cc. of water, the day before the experiment and as part of the experiment, the average diuresis amounted to 0.6 cc. per minute during a half hour period. The highest individual rate was 1.5 cc. per minute. 2. The excretion of cyanol and of azofuchsin I has also been studied. It has been shown that the cyanol excretion curve closely parallels the inulin excretion curve of Kaplan and Smith. Evidence is presented that cyanol is disposed of entirely or mainly by filtration. 3. The excretion of azofuchsin I is not only very different from that of cyanol or inulin, but almost identical with that of phenol red. Evidence is presented that at low plasma concentration azofuchsin is, in the main, secreted.
physiological severity of total occlusion in the coronary artery detected by transthoracic doppler echocardiography at rest: diastolic reverse coronary flow versus exercise 201-TI single photon emission computed tomography
Authors: Ryo Otsuka, Hiroyuki Watanabe, Kumiko Hirata, Kotaro Tokai, Hiroyuki Yamagishi, Takashi Muro, Minoru Yoshiyama, Junichi Yoshikawa
Journal: Journal of the American College of Cardiology (2002)
Antiemetic Efficacy of Dexamethasone
Authors: Maurie Markman, Vivian Sheidler, David S. Ettinger, Shirley A. Quaskey, E. David Mellits
Journal: New England Journal of Medicine (1984)

Original Article from The New England Journal of Medicine — Antiemetic Efficacy of Dexamethasone — Randomized, Double-Blind, Crossover Study with Prochlorperazine in Patients Receiving Cancer Chemotherapy
Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis
Authors: J Bertacchini, M Guida, B Accordi, L Mediani, A M Martelli, P Barozzi, E Petricoin, L Liotta, G Milani, M Giordan, M Luppi, F Forghieri, A De Pol, L Cocco, G Basso, S Marmiroli
Journal: Leukemia (2014)
George S. Sharp, MD
Authors: William Opel
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PET Imaging of Integrin Positive Tumors Using <sup>18</sup>F Labeled Knottin Peptides
Authors: Shuanglong Liu, Hongguang Liu, Gang Ren, Richard H. Kimura, Jennifer R. Cochran, Zhen Cheng
Journal: Theranostics (2011)

Purpose: Cystine knot (knottin) peptides, engineered to bind with high affinity to integrin receptors, have shown promise as molecular imaging agents in living subjects.The aim of the current study was to evaluate tumor uptake and in vivo biodistribution of 18 F-labeled knottins in a U87MG glioblastoma model.Procedures: Engineered knottin mutants 2.5D and 2.5F were synthesized using solid phase peptide synthesis and were folded in vitro, followed by radiolabeling with 4-nitrophenyl 2-18 F-fluoropropionate ( 18 F-NFP).The resulting probes, 18 F-FP-2.5Dand 18 F-FP-2.5F,were evaluated in nude mice bearing U87MG tumor xenografts using microPET and biodistribution studies.Results: MicroPET imaging studies with 18 F-FP-2.5Dand 18 F-FP-2.5Fdemonstrated high tumor uptake in U87MG xenograft mouse models.The probes exhibited rapid clearance from the blood and kidneys, thus leading to excellent tumor-to-normal tissue contrast.Specificity studies confirmed that 18 F-FP-2.5Dand 18 F-FP-2.5Fhad reduced tumor uptake when co-injected with a large excess of the peptidomimetic c(RGDyK) as a blocking agent.Conclusions: 18 F-FP-2.5Dand 18 F-FP-2.5Fshowed reduced gallbladder uptake compared with previously published 18 F-FB-2.5D. 18F-FP-2.5Dand 18 F-FP-2.5Fenabled integrin-specific PET imaging of U87MG tumors with good imaging contrasts. 18F-FP-2.5Ddemonstrated more desirable pharmacokinetics compared to 18 F-FP-2.5F,and thus has greater potential for clinical translation.
Genital Shedding of Herpes Simplex Virus Among Symptomatic and Asymptomatic Persons With HSV-2 Infection
Authors: Elizabeth Tronstein, Christine Johnston, Meei Li Huang, Stacy Selke, Amalia Magaret, Terri Warren, Lawrence Corey, Anna Wald
Journal: JAMA (2011)

<h3>Context</h3>Since herpes simplex virus type 2 (HSV-2) antibody tests have become commercially available, an increasing number of persons have learned that they have genital herpes through serologic testing. The course of natural history of HSV-2 in asymptomatic, seropositive persons is uncertain.<h3>Objective</h3>To evaluate the virologic and clinical course of HSV genital shedding among individuals with symptomatic and asymptomatic HSV-2 infection.<h3>Design, Setting, and Participants</h3>Cohort of 498 immunocompetent HSV-2–seropositive persons enrolled in prospective studies of genital HSV shedding at the University of Washington Virology Research Clinic, Seattle, and Westover Heights Clinic, Portland, Oregon, between March 1992 and April 2008. Each participant obtained daily self-collected swabs of genital secretions for at least 30 days.<h3>Main Outcome Measure</h3>The rate of viral shedding measured by quantitative real-time fluorescence polymerase chain reaction for HSV DNA from genital swabs.<h3>Results</h3>Herpes simplex virus type 2 was detected on 4753 of 23 683 days (20.1%; 95% confidence interval [CI], 18.3%-22.0%) in 410 persons with symptomatic genital HSV-2 infection compared with 519 of 5070 days (10.2%; 95% CI, 7.7%-13.6%) in 88 persons with asymptomatic infection (P &lt; .001). Subclinical shedding rates were higher in persons with symptomatic infection compared with asymptomatic infection (2708 of 20 735 days [13.1%; 95% CI, 11.5%-14.6%) vs 434 of 4929 days [8.8%; 95% CI, 6.3%-11.5%]) (P &lt; .001). However, the amount of HSV detected during subclinical shedding episodes was similar (median, 4.3 [interquartile range, 3.1-5.6] log<sub>10</sub> copies in the symptomatic infection group vs 4.2 [interquartile range, 2.9-5.5] in the asymptomatic infection group, P = .27). Days with lesions accounted for 2045 of 4753 days (43.0%; 95% CI, 39.8%-46.5%) with genital viral shedding among persons with symptomatic genital HSV-2 infection compared with 85 of 519 days (16.4%; 95% CI, 11.2%-23.9%) among persons with asymptomatic infection (P &lt; .001).<h3>Conclusion</h3>Persons with asymptomatic HSV-2 infection shed virus in the genital tract less frequently than persons with symptomatic infection, but much of the difference is attributable to less frequent genital lesions because lesions are accompanied by frequent viral shedding.
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo
Authors: Angell Shieh, Ashley F. Ward, Kegan L. Donlan, Emily R. Harding-Theobald, Jin Xu, Charles G. Mullighan, Chao Zhang, Shann-Ching Chen, Xiaoping Su, James R. Downing, Gideon E. Bollag, Kevin M. Shannon
Journal: Blood (2013)
Failure of hypoxic pulmonary vasoconstriction in patients with liver cirrhosis
Authors: Fuheid S. Daoud, John T. Reeves, John W. Schaefer
Journal: Journal of Clinical Investigation (1972)

The combination of arterial hypoxemia and low pulmonary vascular resistance in patients with liver cirrhosis is unexplained. Pulmonary microcirculatory dilation, but not gross arterio-venous shunts, has been the usual postmortem finding in patients with liver cirrhosis. When 10 patients with alcoholic liver cirrhosis breathed 10% oxygen in nitrogen, they failed to increase their pulmonary vascular resistance. However, four patients with functional murmurs, three patients with hyperkinetic heart syndrome, six patients with normal pulmonary artery pressures and intracardiac left to right shunts, and five patients with renal failure and anemia all increased their pulmonary vascular resistances when they breathed 10% oxygen in nitrogen. These findings suggested that in liver cirrhosis the normal regulating mechanism (hypoxic vasoconstriction) of the pulmonary circulation may be impaired, resulting in failure of the lung to match perfusion with ventilation.
Administration in psychiatry.
Authors: Lindsay E. Beaton
Journal: JAMA (1963)

This book is an encyclopedia; it would be almost as easy to write a comprehensive review of the<i>Britannica</i>. Dr. Barton is one of America's most distinguished psychiatrists, immediate past-president of the American Psychiatric Association, a dean of the country's mental hospital administrators, and, currently, superintendent of the Boston State Hospital. What he writes should be read by anyone interested in the overwhelming problem of management of institutions for the mentally ill. One gathers that this is Dr. Barton's life-long compendium of his experience in mental hospital administration, collected and refined over years of hard practical experience. Treating in detail every conceivable aspect of that difficult craft, this manual contains amazing nuggets of information, from how to search for roaches in the drain pipes (at night, with a flashlight) to a discussion of fees for private psychiatric practice (which made this reviewer look at his books with a flashlight). Yet,
Changes in left ventricular wall motion after coronary artery bypass surgery: signal or noise?
Authors: G M Jeppson, P D Clayton, T J Blair, H V Liddle, R L Jensen, S C Klausner
Journal: Circulation (1981)

We evaluated changes in ventricular wall motion after surgery by comparing smoothed, filtered measurements of regional percent shortening (RPS) from right anterior oblique ventriculograms in 37 patients before and after surgery. After surgery there was a significant (p less than 0.05) decrease in the number of regions with hypokinetic wall motion. The distribution of RPS values was also different (p less than 0.005). However, the mean value of RPS for the surgery group as a whole was not significantly altered. These data were contrasted with RPS data from 11 control patients, who were each studied twice but did not have surgical intervention. Similar analysis of the control group did not show any significant change between studies in the number of hypokinetic regions, and the distributions of RPS for the first and second angiograms were not different. We found a 10.3% absolute mean change in repeated measurements of RPS in the control group. We conclude that significant changes occurred after surgery that were not evident in the control group, and the amount of variability in repeated measurements of RPS suggests that analysis should be applied to group rather than individual data.
Patient, Doctor, Society: A Symposium of Introspections
Authors: Lawrence L. Hirsch
Journal: JAMA (1972)

The discussions in this "symposium of introspections" are clearly designed to stimulate the physician to reevaluate the significance of modern therapy vis-à-vis the individual, society, and the species. From time immemorial, even under conditions when only diagnosis and prognosis were available, the patient was given "everything possible." With the solicitousness of a humane ethic, it was the function—the solemn duty—of the healer to go through the ritual of exhausting even the improbable avenues to "cure." Almost invariably the prognosis was fulfilled; and all involved had expiated, in advance, the sin of not being the victim. As therapeutic nihilism gave way to a dazzling array of miraculous specifics, and as medical art acknowledged medical science, many survived who would previously have perished. However, the time-hallowed ethic remained immutable and, perhaps, became more compelling. It is this situation—a technologically determined morality becoming monolithic and unyielding—that is forcefully yet subtly questioned in<i>Patient,</i>
Physical Activity and Preventing Weight Gain in Women
Authors: Henry S. Kahn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Operative Therapy for Femoral-Popliteal Arterial Occlusive Disease
Authors: NICHOLAS T. KOUCHOUKOS, JEROME F. LEVY, JOHN F. BALFOUR, HARVEY R. BUTCHER
Journal: Circulation (1967)

One hundred ninety-four patients underwent 222 operations for femoral-popliteal arterial occlusive disease between 1957 and 1965. The results of operative therapy employing synthetic bypass grafts, thromboendarterectomy, and autogenous saphenous veins were assessed by determining the accumulative patency rates for the three operative methods, the incidences of subsequent major amputations, and the degree of symptomatic relief (fig. 1, tables 9 and 10). The 2-year accumulative patency rates for synthetic bypass grafts, thromboendarterectomy, and saphenous vein bypass grafts were 28%, 50%, and 63%, respectively (table 8). Subsequent major amputations were performed in 37%, 27%, and 12% of the extremities in the three groups. Improvement in symptoms occurred in 33%, 48%, and 73% of the patients in the respective groups. When grouped according to severity of presenting symptoms and signs and the status of the arterial outflow by arteriography, patency rates were highest in the vein graft group and lowest in the synthetic graft groups. The patency rates after endarterectomy in those extremities with severe symptoms and poor arterial outflow tracts were similar to those of the synthetic graft group.
The Nuclear Orphan Receptor COUP-TFII Plays an Essential Role in Adipogenesis, Glucose Homeostasis, and Energy Metabolism
Authors: Luoping Li, Xin Xie, Jun Qin, George S. Jeha, Pradip K. Saha, Jun Yan, Claire M. Haueter, Lawrence Chan, Sophia Y. Tsai, Ming-Jer Tsai
Journal: Cell Metabolism (2009)
Clinical significance of increased plasma concentration of macrophage colony–stimulating factor in patients with angina pectoris
Authors: Tsutomu Saitoh, Hiroshi Kishida, Yayoi Tsukada, Yumiko Fukuma, Junko Sano, Masahiro Yasutake, Nagaharu Fukuma, Yoshiki Kusama, Hirokazu Hayakawa
Journal: Journal of the American College of Cardiology (2000)
Increasing High-Density Lipoprotein Cholesterol in Dyslipidemia by Cholesteryl Ester Transfer Protein Inhibition
Authors: James S. Forrester, Rajenda Makkar, P.K. Shah
Journal: Circulation (2005)

Reduced HDL cholesterol may be a risk factor comparable in importance to increased LDL cholesterol. Interventions that raise HDL are antiatherosclerotic, presumably through acceleration of reverse cholesterol transport and by antioxidant and antiinflammatory effects. In the hypercholesterolemic rabbit, HDL levels can be increased by >50% by inhibition of cholesteryl ester transfer protein (CETP), a molecule that plays a central role in HDL metabolism. This HDL-raising effect is antiatherosclerotic in moderately severe hyperlipidemia but appears to be ineffective in the presence of severe hypertriglyceridemia. In humans, mutations resulting in CETP inhibition have been associated with both reduced and increased risk of atherosclerosis. Proposed explanations for these apparently disparate observations are that the antiatherosclerotic effect of CETP inhibition varies with either the metabolic milieu or the degree of CETP inhibition. We now have pharmacological inhibitors of CETP that are capable of increasing HDL by as much as 50% to 100% in humans. The importance of this development is that reduced HDL is a risk factor independent of LDL and that these new agents alter HDL by a magnitude comparable to that of statins on LDL. Clinical trials, now beginning, will need to identify the patient subsets in which CETP inhibition may be more or less effective.
Hypothermic protection (26 degrees-25 degrees C) without perfusion cooling for surgery of congenital cardiac defects using prolonged occlusion.
Authors: T Treasure
Journal: Thorax (1988)

Hypothermic protection (26-25C) without perfusion cooling for surgery of congenital cardiac defects using prolonged occlusion.SIR,-The use of periods of circulatory arrest under the protection ofprofound hypothermia (less than 20C) is a well established technique to permit surgery that may be impossible on cardiopulmonary bypass.The time limits are debatable, so the statement by Professor EE Litasova and Dr VN Lomivorotov (March 1988;43:206-1 1) that "The results obtained without perfusion under deep (26-25'C) hypother- mic protection suggest that 75 minutes is a safe time, in terms of brain damage, for circulatory arrest" merits critical attention.25-26'C is quite a modest degree of hypothermia at which to seek prolonged cerebral protection from ischaemia and 75 minutes is a long period of circulatory arrest by any standards.The anaesthetic and surgical techniques are detailed in the "Methods" section but no criteria or objective methods for establishing neurological function were employed.It appears that time to waking has to suffice.The issue of ischaemic brain damage is largely side stepped by attributing unsatis- factory outcome to air embolism or poor myocardial func- tion.A relation was detected between duration of ischaemic time and the number of neurological complications that were recognised, and even by these rather generous criteria it does not suggest that "75 minutes is a safe time."The authors provide nine references, of which six are to Russian publications.Their key reference, from 1963, is fully a quarter ofa century old and maybe none the worse for that, but it may be!The use of circulatory arrest with surface cooling was well established in the 1950s.On the basis of oxygen consumption data-for example, those provided by
The Interaction of Dietary Fibers and Cholesterol upon the Plasma Lipids and Lipoproteins, Sterol Balance, and Bowel Function in Human Subjects
Authors: Thomas L. Raymond, William E. Connor, Don S. Lin, Susan Warner, Martha M. Fry, Sonja L. Connor
Journal: Journal of Clinical Investigation (1977)

To identify any metabolic effects of dietary fiber upon cholesterol metabolism in man, six adult volunteer subjects were fed eucaloric cholesterol-free formula diets, with and without added dietary fiber for two 4-wk periods. A large quantity of dietary fiber was fed, some 60 g of plant cell wall material (or 16 g of crude fiber) derived from corn, beans, bran, pectin, and purified cellulose. This provided about five times the fiber intake of the typical American diet. The addition of fiber to the cholesterol-free diet did not change either the plasma cholesterol level (171±21 mg/dl, SEM, to 167±18) or the triglyceride (103±39 to 93±27 mg/dl). The excretion of both endogenous neutral steroids and bile acids were unchanged with fiber (505±41 to 636±75 mg/day and 194±23 to 266±47 mg/day, respectively.) However, total fecal steroid excretion was increased 699±29 to 902±64 mg/day, P < 0.025). With fiber, intestinal transit time was decreased (59±9 to 35±8 h, P < 0.005), and both the wet and dry stool weights were greatly increased.
Alpha-Fetoprotein in Hepatitis
Authors: TATSUYA ISHIGURO
Journal: Annals of Internal Medicine (1974)

Comments1 March 1974Alpha-Fetoprotein in HepatitisTATSUYA ISHIGURO, M.D.TATSUYA ISHIGURO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-3-425_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: During the recent years several investigators (1-5), using radioimmunoassay, have shown the presence of alphafetoprotein (AFP), not only in the fetal period or in the patients with primary liver cancer, but in the serums of pregnant women or of patients with various nonneoplastic liver diseases.In acute hepatitis we have observed (Figure 1) that the serum alpha-fetoprotein level rose several days later than the serum transaminase level and that even when the serum transaminase level was back to normal the alpha-fetoprotein level still remained significantly high.We believe, in agreement with Seppälä and Ruoslahti (4), that alpha-fetoprotein...References1. RUOSLAHTISEPPÄLÄ EM: Studies of carcino-fetal proteins. III. Development of a radioimmunoassay for αfetoprotein. Demonstration of αfetoprotein in serum of healthy human adults. Int J Cancer 8:374-383, 1971 CrossrefMedlineGoogle Scholar2. SEPPÄLÄRUOSLAHTI ME: Radioimmunoassay of maternal serum alpha-fetoprotein during pregnancy and delivery. Am J Obstet Gynecol 112:208-212, 1972 CrossrefMedlineGoogle Scholar3. RUOSLAHTISEPPÄLÄ EM: Normal and increased alpha-fetoprotein in neoplastic and non-neoplastic liver disease. Lancet 5:278-279, 1972 CrossrefGoogle Scholar4. ISHIGURONISHIMURA TT: Radioimmunoassay of maternal serum αfetoprotein associated with pregnancy. Am J Obstet Gynecol 116:27-33, 1973 CrossrefMedlineGoogle Scholar5. ISHIGURO T: Alpha-fetoprotein in pregnancy (letter). Lancet 1:1509, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Obstetrics and Gynecology Kyoto Hospital of Japan Monopoly Corporation Higashiyamaku, Kyoto 605 Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySerum α-fetoprotein in hydatidiform mole, choriocarcinoma, and twin pregnancy 1 March 1974Volume 80, Issue 3Page: 425-425KeywordsAminotransferasesHepatitis ALiverLiver diseasesPregnancyRadioimmunoassaysΑ-fetoprotein Issue Published: 1 March 1974 PDF DownloadLoading ...