Sudden Death After Methylprednisolone Pulse Therapy
Authors: TOMAS S. BOCANEGRA
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 July 1981Sudden Death After Methylprednisolone Pulse TherapyTOMAS S. BOCANEGRA, M.D., M. OSWALDO CASTANEDA, M.D., LUIS R. ESPINOZA, M.D., FRANK B. VASEY, M.D., BERNARD F. GERMAIN, M.D.TOMAS S. BOCANEGRA, M.D., M. OSWALDO CASTANEDA, M.D., LUIS R. ESPINOZA, M.D., FRANK B. VASEY, M.D., BERNARD F. GERMAIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-1-122_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Corticosteroid pulse therapy is becoming increasingly popular for the treatment of immune-mediated disorders. The current enthusiasm for its use in different clinical settings, including disease of children (1), rests on the apparent absence of serious side effects (2, 3). In a recent editorial in your journal, however, Hess and Kammen (4) stressed the unresolved questions about this modality of treatment, including its safety. We wish to report the cases of two patients who had cardiac arrest in the 24 hours after pulse therapy.Case 1:A 44-year-old man developed skin rash, muscle weakness, pleuritic chest pain, personality...References1. MILLER J. Prolonged use of large intravenous steroid pulses in the rheumatic diseases of children. Pediatrics. 1980;65:989-94. MedlineGoogle Scholar2. BOLTONCOUSER WW. Intravenous pulse methylprednisolone therapy of acute crescentic rapidly progressive glomerulonephritis. Am J Med. 1979;66:495-502. CrossrefMedlineGoogle Scholar3. LIEBLINGLIEBMCLAUGHLIN MEK. Pulse methylprednisolone in rheumatoid arthritis: a double-blind cross-over trial. Ann Intern Med. 1981;94:21-6. LinkGoogle Scholar4. HESSKAMMEN EP. Pulse therapy in rheumatoid arthritis. Ann Intern Med. 1981;94:128-9. Editorial. LinkGoogle Scholar5. GARRETPAULUS RH. Complications of intravenous methylprednisolone pulse therapy. Arthritis Rheum. 1980;23:677. Abstract Google Scholar6. STUBBSMORELL SR. Intravenous methylprednisolone sodium succinate: adverse reactions reported in association with immunosuppressive therapy. Transplant Proc. 1973;5:1145-6. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of South Florida College of Medicine Tampa, FL 33612 Universidad Peruana Cayetano Heredia Lima, Peru PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySystemic CorticosteroidsSteroid-induced Bradycardia During Induction Chemotherapy in Children and Young Adults Diagnosed With Acute Lymphoblastic Leukemia and Lymphoblastic LymphomaElectrocardiographic changes after high-dose corticosteroid pulse therapy in pemphigus patientsCardiotoxicity of antiemetic drugs in oncology: An overview of the current state of the artImmediate and Delayed Hypersensitivity Reactions to Corticosteroids: Evaluation and ManagementCorticosteroid-induced bradycardiaBradycardia after dexamethasone for postoperative nausea and vomiting prophylaxis during induction of anaesthesiaPlasma Pharmacokinetics and Tissue Disposition of Novel Dextran–Methylprednisolone Conjugates With Peptide Linkers in RatsCardiac Arrest After Methylprednisolone Pulse Therapy Rescued Using Extracorporeal Membrane Oxygenation in Patients With Acute Cardiac Rejection: Two Case ReportsSteroids and BradycardiaAcute Myocardial Infarction During High-Dose Methylprednisolone therapy for Graves’ OphthalmopathyAttenuation of Acute Rejection in a Rat Liver Transplantation Model by a Liver-Targeted Dextran Prodrug of MethylprednisoloneFirst report of supraventricular tachycardia after intravenous pulse methylprednisolone therapy, with a brief review of the literatureCardiovascular effects of corticosteroid pulse therapy: a prospective controlled study on pemphigus patientsCORTICOSTEROID USE IN SYSTEMIC LUPUS ERYTHEMATOSUSClinical Use of SteroidOral and intravenous steroids in giant cell arteritisIntravenous pulses of methylprednisolone for systemic lupus erythematosusCorticosteroid-induced hypersensitivity reactionsPyoderma GangrenosumAtrial Fibrillation Associated With Systemic Lupus Erythematosus and Use of MethylprednisoloneSyndrome d’hypersensibilité médicamenteuse en pratique interniste : pièges diagnostique et thérapeutique.Huit observationsRisks and Benefits of Preoperative High Dose Methylprednisolone in Surgical PatientsRECURRENT CARDIOCIRCULATORY ARREST AFTER KIDNEY TRANSPLANTATION RELATED TO INTRAVENOUS METHYLPREDNISOLONE BOLUS THERAPYAllergic-Type Reactions to CorticosteroidsEfficacy of high-dose methylprednisolone as a first-line therapy in adult patients with idiopathic thrombocytopenic purpuraTreatment Algorithm for Autoimmune Myasthenia Gravis in ChildhoodSIDE EFFECTS OF IMMUNOSUPPRESSANT THERAPIES USED IN NEUROLOGYMANAGEMENT OF COMPLICATIONS OF GLUCOCORTICOID THERAPYProgressive Visual Loss from Giant Cell Arteritis Despite High-dose Intravenous MethylprednisolonePulse corticosteroid therapy for cutaneous diseasesEffects of methylprednisolone on the GABA- and glutamate-induced currents: Relevance to glucocorticoid-induced neurotoxicity and brain agingTreatment of pyoderma gangrenosumMinimizing Complications from Systemic Glucocorticosteroid UseREFRACTORY RHEUMATOID ARTHRITISSevere adverse cardiovascular effects of pulse steroid therapy: Is continuous cardiac monitoring necessary?Corticosteroid pulse therapy in active rheumatoid arthritisAtrial Fibrillation Following Pulse Methylprednisolone Therapy in an AdultProarrhythmia of nonantiarrhythmic drugsIV Steroid Treatment of Giant Cell ArteritisCardiovascular Collapse After High Dose MethylprednisoloneThe biology and clinical application of systemic glucocorticoidsAre late potentials operative in arrhythmias following methylprednisolone pulse therapyTransient renal failure following intravenous methylprednisolone pulse therapyA Study of Adverse Effects of High-Dose Intravenous (Pulse) Methylprednisolone Therapy in Patients with Rheumatic DiseaseHigh-dose methylprednisolone sodium succinate as a single agent in relapsed childhood acute lymphoblastic leukaemiaRheumatic DisordersVisual Recovery in Two Patients after Intravenous Methylprednisolone Treatment of Central Retinal Artery Occlusion Secondary to Giant-cell ArteriesTreatment of Childhood Steroid-Resistant Focal Segmental Glomerulosclerosis with Pulse Methylprednisolone and Alkylating AgentsCorticosteroids for Acute, Severe AsthmaFatal acute pyelonephritis following pulsed methylprednisolone for rheumatoid arthritis.Correlation of iron exchange between the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one(L1) and transferrin and possible antianaemic effects of L1 in rheumatoid arthritis.Methylprednisolone induces activation of the contact system in a dose-dependent manner. 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MOSES, D.O., ALICE MCCORMICK, D.O., WILLIAM NICKEY, D.O. 1 July 1981Volume 95, Issue 1Page: 122-122KeywordsChildrenCorticosteroid therapyHeartHeart rateIschemiaMusclesRashesSafety Issue Published: 1 July 1981 PDF downloadLoading ...