tbuckley/cabot-search huggingface dataset:
Foundations of Modern Neurology: A Century of Progress
Authors: Charles M. Poser
Journal: JAMA (1994)

Robert Aird is professor emeritus of neurology at the University of California, San Francisco. This book is a highly personal, eclectic collection of essays about an enormous number of clinical neuroscientists. Some will disagree with his choices, while others will decry his omissions. The essays embody fascinating historical and personal nuggets, many possibly apocryphal and some probably unfounded. They reveal as much about the author as about his subjects. Much of the charm of the book is due to the fact that all these prominent people were personal acquaintances of Dr Aird. The book unquestionably fulfills the author's purpose, which is "to give recognition to that generation of neurologists and neuroscientists who firmly established modern neurology and its related fields as independent disciplines." It is a worthy successor to Webb Haymaker's famous<i>The Founders of Neurology</i>but differs because a number of the vignettes deal with individuals who are still
Unusual cutaneous manifestations of myelodysplastic syndrome
Authors: Y. SUZUKI, K. KURODA, T. KOJIMA, M. FUJITA, T. ISEKI, H. SHINKAI
Journal: British Journal of Dermatology (1995)

We report a 58-year-old patient with acute myeloid leukaemia who developed an oedematous erythema resembling Sweet's syndrome, accompanied by atypical erythema nodosum and bullous pyoderma gangrenosum. Examination of skin biopsies showed dense infiltration with mature neutrophils. although there was peripheral blood leucocytopenia. The oedematous erythema worsened after he was treated with granulocyte-colony-stimulating factor (G-CSF), which was given For his leucocytopenia. We suggest that when a neutrophilic dermatosis complicates leukaemia, alternatives to G-CSF should be considered for the treatment of leucocytopenia. Corticosteroids were very effective in controlling the skin lesions in our patient.
Which Patients Benefit From Percutaneous Mitral Balloon Valvuloplasty?
Authors: Igor F. Palacios, Pedro L. Sanchez, Lari C. Harrell, Arthur E. Weyman, Peter C. Block
Journal: Circulation (2002)

Percutaneous mitral balloon valvuloplasty (PMV) results in good immediate results, particularly in patients with echocardiographic scores (Echo-Sc) < or =8. However, which variables relate to long-term outcome is unclear.We report the immediate and long-term clinical follow-up (mean, 4.2+/-3.7 years; range, 0.5 to 15) of 879 patients who underwent 939 PMV procedures. Patients were divided into 2 groups, Echo-Sc < or =8 (n=601) and Echo-Sc >8 (n=278). PMV resulted in an increase in mitral valve area from 1.0+/-0.3 to 2.0+/-0.6 cm2 in patients with Echo-Sc < or =8 and from 0.8+/-0.3 to 1.6+/-0.6 cm2 in patients with Echo-Sc >8 (P<0.0001). Although adverse events (death, mitral valve surgery, and redo PMV) were low within the first 5 years of follow-up, a progressive number of events occurred beyond this period. Nevertheless, survival (82% versus 57%) and event-free survival (38% versus 22%) at 12-year follow-up was greater in patients with Echo-Sc < or =8 (P<0.0001). Cox regression analysis identified post-PMV mitral regurgitation > or =3+, Echo-Sc >8, age, prior surgical commissurotomy, NYHA functional class IV, pre-PMV mitral regurgitation > or =2+, and higher post-PMV pulmonary artery pressure as independent predictors of combined events at long-term follow-up.The immediate and long-term outcome of patients undergoing PMV is multifactorial. The use of the Echo-Sc in conjunction with other clinical and morphological predictors of PMV outcome allows identification of patients who will obtain the best outcome from PMV.
ADDRESS TO THE HOUSE OF DELEGATES
Authors: E. Vincent Askey
Journal: JAMA (1960)

TODAY I should like to call your attention to a few specific areas which I believe demand careful study and concerted effort by the entire profession. First, however, I want to pay sincere personal tribute to my predecessor, Dr. Louis M. Orr. During the past year he has carried out his presidential duties with great energy and dedication. He has been a forceful, articulate spokesman for American medicine, recognized not only by his colleagues but by the public as a whole. I hope that I can come reasonably close to the quality of leadership provided by Dr. Orr. As we now look at the year and the decade ahead, I strongly urge intensified, accelerated effort in five particular fields: (1) medical education, (2) preparations for the White House Conference on Aging, (3) voluntary health insurance and the related problem of third party relationships, (4) membership, and (5) mental health. <h3>Medical</h3>
Mutations in GJB6 cause hidrotic ectodermal dysplasia
Authors: Jérôme Lamartine, Guilherme Munhoz Essenfelder, Zoha Kibar, Isabelle Lanneluc, Edwige Callouet, Dalila Laoudj, Gilles Lemaître, Colette Hand, Susan J. Hayflick, Jonathan Zonana, Stylianos Antonarakis, Uppala Radhakrishna, David P. Kelsell, Arnold L. Christianson, Amandine Pitaval, Vazken Der Kaloustian, Clarke Fraser, Claudine Blanchet-Bardon, Guy A. Rouleau, Gilles Waksman
Journal: Nature Genetics (2000)
Texas Prepares To Invest Billions In Cancer Research
Authors: J. B. Finkelstein
Journal: JNCI Journal of the National Cancer Institute (2008)

exas is moving forward with a $3 billion bond issue that promises to bolster cancer research in the state.Voters approved a constitutional amendment late last year that will allow the state to fund $300 million in cancer research annually over the next 10 years.Those dollars are expected to start flowing sometime next year, once the Cancer Prevention and Research Institute, established under the amendment, is ready to oversee the grantmaking process.Several members were recently named to an oversight committee that will soon take the first steps in establishing the institute by picking a location and director.Motivated by the death of former Gov. Ann Richards from esophageal cancer in 2006, a group of national and local advocacy organizations, working with both the governor's offi ce and a core group of lawmakers, initiated and lobbied for the constitutional amendment in the state legislature."This didn't initiate with the medical community.This initiated with citizens in Texas and members of the
Impact of Referral Source and Study Applicants’ Preference for Randomly Assigned Service on Research Enrollment, Service Engagement, and Evaluative Outcomes
Authors: Cathaleene Macias, Paul Barreira, William Hargreaves, Leonard Bickman, William Fisher, Elliot Aronson
Journal: American Journal of Psychiatry (2005)

The inability to blind research participants to their experimental conditions is the Achilles' heel of mental health services research. When one experimental condition receives more disappointed participants, or more satisfied participants, research findings can be biased in spite of random assignment. The authors explored the potential for research participants' preference for one experimental program over another to compromise the generalizability and validity of randomized controlled service evaluations as well as cross-study comparisons.Three Cox regression analyses measured the impact of applicants' service assignment preference on research project enrollment, engagement in assigned services, and a service-related outcome, competitive employment.A stated service preference, referral by an agency with a low level of continuity in outpatient care, and willingness to switch from current services were significant positive predictors of research enrollment. Match to service assignment preference was a significant positive predictor of service engagement, and mismatch to assignment preference was a significant negative predictor of both service engagement and employment outcome.Referral source type and service assignment preference should be routinely measured and statistically controlled for in all studies of mental health service effectiveness to provide a sound empirical base for evidence-based practice.
576 Non alcoholic fatty liver disease (NAFLD) and insulin resistance: Does PC-1K121Q play a role?
Authors: L. Carulli, I. Canedi, S. Rondinella, S. Lombardini, A.M. Verrone, M. Ricchi, A. Lonardo, M. Bertolotti, N. Carulli, P. Loria
Journal: Journal of Hepatology (2004)
MISDIAGNOSIS AND MISMANAGEMENT OF EARLY INTERVERTEBRAL DISK LESIONS
Authors: L. Stanley Sell
Journal: JAMA (1952)

In practicing medicine in an area where a large portion of the active male population is engaged in either farming or ranching, one is startlingly impressed by the high percentage of lumbar disk lesions in those patients who present themselves with a low back complaint. In my opinion, this is definitely not a chance correlation but is rather the result of certain occupational hazards. The main theme of this paper is that these disk lesions are all too frequently misdiagnosed and subsequently mismanaged by general practitioners and others unfamiliar with certain fundamentals of orthopedic practice. More than 45 years have passed since Goldthwait and Osgood<sup>1</sup>published their work on subluxations and strains of the sacroiliac joint, and the impact of their teachings on medical opinion is amply attested to by the fact that many physicians still attribute low back complaints to ailments having their origin in or around the
Notifying Participants of Clinical Trial Results—Reply
Authors: Ann Partridge
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corticosteroid Therapy for Boecks Sarcoid
Authors: V.N. Houk
Journal: JAMA (1963)

THE VARIABLE NATURAL course of Boeck's sarcoid involving the lungs has made prognosis in general—and the value of corticosteroid therapy in particular—difficult to define.1-5As a result, despite the extensive use of corticosteroids for  sarcoidosis, the extent to which such therapy can alter the course of the disease remains controversial. There is general agreement, however, that prognosis can be best related to pulmonary functional, not radiographic, status. Therefore, whether or not radiographic clearing is a result of corticosteroid therapy, it is important to establish the relationship between improvement as seen on roentgenograms and physiological improvement. It is the purpose of this communication to report on an individual who was essentially asymptomatic clinically but who demonstrated both significant impairment of pulmonary function and extensive roentgenographic evidence of abnormality when first seen. Within the initial 15 days of corticosteroid treatment, rapid clearing of pulmonary infiltration occurred. Improvement that was seen
Sleep and wakefulness, trivial and non-trivial: Which is which?
Authors: Rubén V. Rial, María C. Nicolau, Antoni Gamundí, Mourad Akaârir, Sara Aparicio, Celia Garau, Silvia Tejada, Catalina Roca, Lluis Gené, David Moranta, Susana Esteban
Journal: Sleep Medicine Reviews (2007)
Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations in<i>MYH</i>
Authors: Oliver M. Sieber, Lara Lipton, Michael Crabtree, Karl Heinimann, Paulo Fidalgo, Robin K.S. Phillips, Marie-Luise Bisgaard, Torben F. Orntoft, Lauri A. Aaltonen, Shirley V. Hodgson, Huw J.W. Thomas, Ian P.M. Tomlinson
Journal: New England Journal of Medicine (2003)

Germ-line mutations in the base-excision–repair gene MYH have been associated with recessive inheritance of multiple colorectal adenomas. Tumors from affected persons displayed excess somatic transversions of a guanine–cytosine pair to a thymine–adenine pair (G:C→T:A) in the APC gene.
Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo
Authors: Zhi-Ying Chen, Cheng-Yi He, Anja Ehrhardt, Mark A Kay
Journal: Molecular Therapy (2003)

The loss of transgene expression has been a major obstacle to the development of nonviral vectors for the treatment of human diseases. We previously demonstrated that bacterial DNA linked to a mammalian expression cassette resulted in transcriptional silencing of the transgene in vivo. To confirm these studies and develop a means to produce a robust DNA vector that is not silenced in vivo, we developed a phage phiC31 integrase-mediated intramolecular recombination technology to prepare minicircle vector DNA devoid of the bacterial backbone and then compared the transgene expression profile of the minicircle with different molecular forms of plasmid DNAs in mice. We demonstrate that minicircular DNAs devoid of bacterial sequences expressed 45- and 560-fold more serum human factor IX and alpha1-antitrypsin, respectively, compared to standard plasmid DNAs transfected into mouse liver. Our data suggest that minicircles are capable of expressing high and persistent levels of therapeutic products in vivo and have a great potential to serve as episomal vectors for the treatment of a wide variety of diseases.
Observations on Partial Paralysis
Authors: C. M. Durrant
Journal: BMJ (1859)

thing that occurred.There was a large wound, about four inches long, over the right side of the head, running across the middle of the right parietal bone.The bone was exposed for the space of a shilling piece.The wound was very ragged, and part of the scalp was torn downwards from the pericranium.There was a wound on the left side of the head, just behind the external angular process of the frontal bone, of about the size of a florin piece; the wound was very ragged, and led down to a comminuted fracture of the skull, which was driven some- what into its cavity.Pulse 60, rather weak.The pupils were regular, and acted.Wet dressing was applied.At 9 P.M.Mr.Pollock saw him, and extracted all the loose portions of bone; they showed, on their internal surface, the ramifications of the meningeal artery, and appeared to belong, at least some of them, to the great wing of the sphenoid.There were about six pieces, and when put together, made a circumference of the size almost of a florin.There was no bleeding.The dura mater was seen exposed, but healthy.The brain appeared to be at some distance from the skull.12 P.M.He is very quiet; has no great pain in the head; pulse 60, quiet.October 21st.Pulse 72; rather full.He does not complain of his head, and is very quiet.He was ordered to have four grains of calomel immediately, and a senna draught in four hours.October 22nd.The wound is very quiet.Pulse 80.The bowels were freely open after the purgatives.October 23rd (1 A.M.) During the last hour he has been restless, getting out of bed twice; and complained much of his head.When seen, he was constantly moving his right arm to and fro, not convulsively; but when spoken to, he answered rationally.Pulse 84, and soft.The face has lately been
Liver Disease in Cytomegalovirus Mononucleosis: A Light Microscopical and Immunoperoxidase Study of Six Cases
Authors: Dale C. Snover, Charles A. Horwitz
Journal: Hepatology (1984)

Six liver biopsies from previously healthy adult patients with cytomegalovirus (CMV) mononucleosis were studied by routine light microscopy and by the immunoperoxidase technique for CMV antigen. Light microscopical findings consisting of a mononuclear portal and sinusoidal infiltrate, increased hepatocellular mitotic activity and minimal hepatocellular necrosis were consistently found. Less common features were granuloma formation and bile duct epithelial damage. Typical CMV nuclear inclusions and CMV antigen were identified in only one case, a patient with marked leukopenia secondary to CMV who had received corticosteroid therapy. The other five cases contained no inclusions and CMV antigen could not be identified by immunoperoxidase staining. This data suggests that, as with hepatitis B, viral antigen is not identifiable in acute CMV hepatitis in the immunocompetent host, perhaps due to active destruction of infected cells. The immunoperoxidase technique for CMV appears to be of little value in the diagnosis of acute CMV hepatitis.
The Speckled Monster: A Historical Tale of Battling Smallpox
Authors: J. A. Rosenfeld
Journal: BMJ (2004)

Today we can hardly imagine the devastation wrought by smallpox. Not only was it a dreadful personal torment, entailing days or weeks of suffering a painful, odorous hell before death, it was also a community and familial catastrophe, killing hundreds and sparing few. Jennifer Lee Carrell conveys the immensity of the smallpox pestilence, the scarring, destruction, and death that we have been spared through the works of the men and women she chronicles.

In …
Modified Mediterranean diet and survival
Authors: Antonia Trichopoulou
Journal: BMJ (2005)

Modified Mediterranean diet and survival Evidence for diet linked longevity is substantialEditor-The EPIC-elderly cohort study was designed to investigate the association between a modified Mediterranean diet and longer life expectancy among an elderly subpopulation (older than 60) that is part of the larger EPIC (European Prospective Investigation into Cancer and Nutrition) cohort. 1 2 Focusing the attention on a sample with a more restricted age range seems to reinforce previous findings on diet linked longevity, but important risk factors were not taken into account in collecting the data.Total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and blood pressure are well known determinants of cardiovascular disease.The study's outcomes are expressed in term of mortality, and cardiovascular disease remains the most important of all causes of death.The benefits of a healthy eating pattern with respect to these variables have been shown. 3he same might not be sustained if the total EPIC cohort were considered (aged 20-85). 2 Have the authors considered any possible statistical gain from including these risk factors in the analysis when considering the younger subgroup?We believe that the conclusions for participants older than 60 are stronger if the risk of cardiovascular disease in men and women after the menopause is considered.In a world in which people eat mainly processed foods that are rich in saturated fats, the analysis is a warning to adopt a healthier dietary pattern and, broadly, lifestyle changes.
Low Molecular-weight Dextran for Foetal Distress
Authors: C. N. McFarlane
Journal: BMJ (1964)

areas-notably those heavily industrialized and heavily populated-where a hospital- confinement rate higher than 70% is desirable.It is in those areas presumably that the effects of the expected increase in the birth rate will also be more keenly felt and the evil effects of too early discharge most likely to be seen, and, as Sir Andrew warns us, " do not let us therefore imagine that it is the ideal arrangement."From the beginning, those most earnestly advocating this makeshift have been obsessed with only one aspect of its value, and, inasmuch as it is aimed at reducing the risks of labour itself, it obviously serves its purpose.When labour is successfully ended there are two individuals for whose welfare we and our colleagues, the paediatricians, are jointly
Intellectual Disability and Ill Health: A Review of the Evidence
Authors: Philip E. Veenhuis
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemodectoma in relation to the aortic arch (aortic body tumour): A clinical report
Authors: R. Wilkinson, R. Forgan-Smith
Journal: Thorax (1969)

Tumours of the aortic body in man are relatively rare and were first described in 1950. Aortic bodies are found in the region of the base of the heart and great vessels, are thought to be of neuroepithelial origin, and have a role in maintenance of circulatory homoeostasis. A clinical report is presented of a benign aortic body tumour which was removed surgically from a 61-year-old woman.
Low Levels of Cytokines and Growth Factors in Serum of Allergic and Non-Allergic Top Atletes
Authors: M. Bonini, B. Ruckert, D. Fioretti, C. Gramiccioni, V. Sargentini, M. Rinaldi, C. Akdis, G.W. Canonica, C. Tranquilli, A. Pelliccia, S. Bonini
Journal: Journal of Allergy and Clinical Immunology (2011)
Thomas de Quincy and the Medical Profession
Authors: Jerome D. Greene
Journal: New England Journal of Medicine (1956)

IN one of Thomas De Quincy's narrative and miscellaneous papers, the Spanish Nun, two passages have a certain medical interest. The first evokes one's curiosity by his use of the word antiseptic in a sense that suggests to a modern reader the meaning it has derived only since the discoveries of Pasteur, Koch and Lister. Yet De Quincy died in 1859, seventeen years before Pasteur's work on the fermentation of beer and Koch's isolation of the bacillus of anthrax, and still longer before Lister's application of the antiseptic method to surgery. One wonders when the word became current in . . .
Scotland <i>v</i> England deal on prescribed drugs
Authors: David J Webb, Kenneth R Paterson, Angela Timoney, Andrew Walker
Journal: BMJ (2006)

We were disappointed to read the recent news article by Watts.1 On what seems to be no more evidence than an article in the Daily Mail he argues that application of the Barnett formula allows Scotland, through higher per capita funding, to be more free and easy in its approval of new medicines. A good story—the only problem is that he is completely wrong in his analysis. 

The National Institute for Health and Clinical Excellence …