Delta Infection in Hepatocellular Carcinoma Positive for Hepatitis B Surface Antigen
Authors: GIOVANNI RAIMONDO
Journal: Annals of Internal Medicine (1984)

Brief Reports1 September 1984Delta Infection in Hepatocellular Carcinoma Positive for Hepatitis B Surface AntigenGIOVANNI RAIMONDO, M.D., ANTONIO CRAXI, M.D., GIUSEPPE LONGO, M.D., GANDOLFO GIANNUOLI, M.D., MARIA CALTAGIRONE, M.D., MARCELLO ARAGONA, M.D., GABRIELLA PECORARO, M.D., GIUSEPPE SQUADRITO, M.D., LUIGI PAGLIARO, M.D.GIOVANNI RAIMONDO, M.D., ANTONIO CRAXI, M.D., GIUSEPPE LONGO, M.D., GANDOLFO GIANNUOLI, M.D., MARIA CALTAGIRONE, M.D., MARCELLO ARAGONA, M.D., GABRIELLA PECORARO, M.D., GIUSEPPE SQUADRITO, M.D., LUIGI PAGLIARO, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-3-343 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChronic hepatitis B virus infection plays a major etio-logic role in hepatocellular carcinoma (1). In southern Italy, where the hepatitis B surface antigen (HBsAg) carrier status has an intermediate prevalence between high- and low-risk areas (2), hepatitis B virus has been confirmed as the main risk factor for hepatocellular carcinoma (3). In the same region superinfection of HBsAg carriers with the delta agent, a defective virus requiring helper functions of hepatitis B virus, is widespread and closely associated with chronic active liver disease (4). The prevalence of markers of delta infection in patients with HBsAg-positive hepatocellular carcinoma was compared to...References1. BEASLEYHWANGLINCHIEN RLCC. Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22 707 men in Taiwan. Lancet. 1981;2:1129-32. CrossrefMedlineGoogle Scholar2. GIUSTI G. Rapporti virus-ospite: Dimensioni del problema. In: COLTORTI M, ed. : II portatore di HBsAg. Editr. Compositori, Bologna 1981, p. 7-16. Google Scholar3. PAGLIAROSIMONETTICRAXI LRA. Alcohol and HBV infection as risk factors for hepatocellular carcinoma in Italy: a multicentre controlled study. Hepatogastroenterology. 1983; 30:48-51. Google Scholar4. CRAXIRAIMONDOLONGO AGG. Delta agent infection in acute hepatitis and chronic HBsAg carriers with and without liver disease. Gut. 1984. (In press). CrossrefMedlineGoogle Scholar5. RIZZETTOSHIHGERIN MJJ. The hepatitis B virus-associated delta antigen: isolation from liver, development of solid-phase radioimmunoassays for delta antigen and anti-delta and partial characterization of delta antigen. J Immunol. 1980;125:318-24. MedlineGoogle Scholar6. SMEDILELAVARINICRIVELLIRAIMONDOFASSONERIZZETTO ACOGMM. Radioimmunoassay detection of IgM antibodies to the HBV-associated delta antigen: clinical significance in delta infection. J Med Virol. 1982;9:131-8. CrossrefMedlineGoogle Scholar7. SMEDILEDENTICOZANETTI APA. Infection with the delta agent in chronic HBsAg carriers. Gastroenterology. 1981;81:992-7. CrossrefMedlineGoogle Scholar8. RIZZETTOVERMERECCHIA GGS. Chronic hepatitis in carriers of hepatitis B surface antigen with intrahepatic expression of the delta antigen: an active and progressive disease unresponsive to immunosuppressive treatment. Ann Intern Med. 1983;98:437-41. LinkGoogle Scholar9. GOVINDARAJANHEVIAPETERS GFR. Prevalence of delta antigen/antibody in B viral induced hepatocellular carcinoma. Cancer. 1984. (In press). CrossrefMedlineGoogle Scholar10. HADZIYANNIS S. Delta antigen positive chronic liver disease in Greece: clinical aspects and natural course. In: RIZZETTO M, VERME G, BONINO F, eds. Viral Hepatitis and Delta Infection. New York; Alan R. Liss; 1984. (In press). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Messina Messina Italy University of Palermo Palermo Italy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatitis viruses (other than hepatitis B and C viruses) as causes of hepatocellular carcinoma: an updateRising incidence of hepatocellular carcinoma: the role of hepatitis B and C; the impact on transplantation and outcomesComparison of clinico-pathological features in hepatitis B virus-associated hepatocellular carcinoma with or without hepatitis D virus superinfectionLong-term interferon-α treatment of children with chronic hepatitis delta: a multicentre studyOccurrence of hepatocellular carcinoma and decompensation in western european patients with cirrhosis type BRisk of liver cirrhosis and hepatocellular carcinoma in subjects with hepatitis B and delta virus infection: A study from Kure, JapanInteraction between HDV and HBV infection in HBsAg-chronic carriersHepatocellular carcinoma following chronic delta virus hepatitis in a patient cured of leukemiaHepatitis delta virus as a global health problemA study on delta virus infection and its clinical impact in IranDelta Virus HepatitisSerological markers of hepatitis B virus and hepatitis D virus infections in Greek adults with primary hepatocellular carcinomaThe epidemiology and clinical outcome of hepatitis D virus (delta) infection in JordanDelta Agent HepatitisDelta agent and the etiology of hepatocellular carcinomaHepatitis delta infections. 1 September 1984Volume 101, Issue 3Page: 343-344KeywordsHepatitisHepatitis AHepatitis B surface antigenHepatitis B virusHepatitis DHepatitis D virusHepatocellular carcinomaLiver diseasesMedical risk factorsSuperinfections Issue Published: 1 September 1984 PDF downloadLoading ...