Cryptococcal Meningitis and Fluconazole
Authors: BERTRAND DUPONT
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 May 1987Cryptococcal Meningitis and FluconazoleBERTRAND DUPONT, M.D., EDOUARD DROUHET, M.D.BERTRAND DUPONT, M.D.Search for more papers by this author, EDOUARD DROUHET, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-778_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We report a case of cryptococcal meningitis in a patient with the acquired immunodeficiency syndrome (AIDS) that was cleared by oral fluconazole. The patient is doing well on a maintenance therapy with this new azole derivative developed by Pfizer Central Research, Kent, England (1, 2).A 27-year-old man with positive antibodies for the human immunodeficiency virus (HIV) had cryptococcal meningitis in January 1986. Treatment with intravenous amphotericin B 30 to 40 mg every second day, and oral flucytosine, 100 mg/kg body weight · d all resolved symptoms, and culture from cerebrospinal fluid became negative. However, granulocytopenia developed...References1. PERFECTDURACK JD. Penetration of imidazoles and triazoles into cerebrospinal fluid of rabbits. J Antimicrob Chemother. 1985;16:81-6. CrossrefMedlineGoogle Scholar2. PERFECTSAVANIDURACK JDD. Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and Candida pyelonephritis in rabbits. Antimicrob Agents Chemother. 1986;29:579-83. CrossrefMedlineGoogle Scholar3. ZUGERLOUIEHOLZMANSIMBERKOFFRAHAL AERMJ. Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1986;104:234-40. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BERTRAND DUPONT, M.D.; EDOUARD DROUHET, M.D.Affiliations: Pasteur Institute Hospital Paris France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTherapy of CryptococcosisEpidemiology of HIV-associated cryptococcosis in France (1985–2001)Fluconazole vs. Amphotericin B for the Treatment of Neonatal Fungal Septicemia: A Prospective Randomized TrialCryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformansAntifungal properties of essential oils and their main components uponCryptococcus neoformansCryptococcal meningitis: the place of itraconazoleMitteilungEfficacy of fluconazole in the treatment of systemic fungal infectionsCryptococcal Infection in AIDSAntifungal Agents Used for Deep-Seated Mycotic InfectionsCryptococcal meningitis associated with acquired immunodeficiency syndrome (AIDS) in African patients: treatment with fluconazoleFailure of fluconazole treatment in cryptococcal meningitis despite adequate CSF levelsFluconazole therapy of disseminated cryptococcosis in AIDS patients with liver cirrhosisFluconazoleAntifungal chemotherapy — Are we winning?Cryptococcal meningoencephalitis in a patient with Hodgkin's lymphoma: successful treatment with fluconazoleImprovement of amphotericin B activity during experimental cryptococcosis by incorporation into specific immunoliposomesThe value of serum cryptococcal antigen in the diagnosis of cryptococcal infection in patients infected with the human immunodeficiency virusFluconazole, a New Antifungal AgentJohn N. 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Dismukes, MDTreatment of systemic fungal infections: Recent progress and current problemsTreatment of Infections Associated with Human Immunodeficiency VirusCryptococcosis and AIDSFungal Infections in AIDSLes antimycosiques en 1988Overview of medically important antifungal azole derivativesCryptococcal Meningitis in the Acquired Immunodeficiency Syndrome (AIDS): Successful Treatment with Fluconazole after Failure of Amphotericin BWILLIAM R. BYRNE, M.D., CHARLES P. WAJSZCZUK, M.D.Pharmacokinetics of fluconazole in cerebrospinal fluid and serum in human coccidioidal meningitis 1 May 1987Volume 106, Issue 5Page: 778-778KeywordsAIDSAmphotericinAntibodiesBody weightCerebrospinal fluidCryptococcal meningitisHIV ePublished: 1 December 2008 Issue Published: 1 May 1987 PDF downloadLoading ...