tbuckley/cabot-search huggingface dataset:
Abstract 4224: MiR-7 and its novel target regulate sensitivity to microtubule stabilizing agents
Authors: Lingling Liu, Charles E. Rogler, Susan Band Horwitz, Hayley M. McDaid
Journal: Cancer Research (2012)

Abstract Microtubule stabilizing drugs, such as Taxol that is used in the treatment of numerous malignancies, cause distinct responses in cancer cells, including apoptosis, mitotic catastrophe, necrosis and accelerated senescence. However, drug resistance, a complex and mutlifactorial phenotype, is a major obstacle to therapy and the foremost cause of disease progression and cancer-related mortality. MiRNAs are small non-coding RNAs that regulate protein expression by targeting their 3′UTRs, and are emerging as key regulators of cancer pathogenesis that can influence sensitivity to chemotherapy and radiotherapy. We have identified miR-7 as a regulator of sensitivity to the microtubule-stabilizing agents, discodermolide and Taxol. Over-expression of miR-7 in the lung cancer cell lines A549 and H2122, strongly inhibited cell proliferation and sensitized the cells to drug-induced apoptosis. Over-expression of miR-7 also increased the number of acidic lysosomes, as measured by β-galactosidase activity, which likely reflects lysosomal stress. It also increased basal and drug-induced caspase activation, which most likely mediate the sensitizing effects of discodermolide and Taxol. In addition, we validated that the transcription factor, Kruppel like factor 4 (KLF4) is a target of miR-7, and that its expression also regulates sensitivity to discodermolide and Taxol. KLF4 is suppressed in discodermolide- and Taxol-treated A549 cells that have a strong senescent phenotype, and is over-expressed in A549 cells that are resistant to either drugs. ShRNA-mediated knockdown of KLF4 in A549 and H2122 also sensitized cells to discodermolide and Taxol though to a lesser degree than miR-7 overexpression, and also inhibited cell proliferation and increased lysosomal β-galactosidase activity and caspase activity. Thus, we hypothesize that suppression of KLF4 partially mediates the potent anti-tumor effects of miR-7 in A549 and H2122 lung cancer cells. In summary, we have identified miR-7 and its novel target, KLF4, as important regulators of sensitivity to discodermolide and Taxol, and suggest that miR-7 is a promising candidate for therapeutic development. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4224. doi:1538-7445.AM2012-4224
The Family Practitioner and Psychiatric Problems in the Old-Reply
Authors: Pearl S. German
Journal: JAMA (1987)

<h3>In Reply.—</h3> Dr Smith describes the dilemma of concerned family and general practitioners regarding mental morbidity in the older patient. He counsels very strongly that training and other approaches intended to increase skills of these practitioners are essential. In this, he shares the concern that motivated the study reported in the Jan 23/30 issue of<i>JAMA</i>, which concludes with the opinion that some strategy aimed at helping the family practitioner is necessary. The General Health Questionnaire, which was used in our study, may not be the most effective strategy, and certainly more investigation is indicated. Better designed and targeted training as well as interventions to increase the awareness of clinicians are both indicated. We join Dr Smith in calling attention to the fact that the elderly do have psychological and emotional problems requiring attention.
Management of menorrhagia: an audit of practices in the Anglia menorrhagia education study
Authors: G. R K Fender
Journal: BMJ (2001)

Menorrhagia is an important healthcare problem for women.1 In primary care menorrhagia is a considerable burden on resources and may ultimately lead to referral and surgery. 1 2 There is a gap between research and practice, with best evidence not uniformly applied. The Anglia menorrhagia education study, a randomised controlled trial of an educational package delivered in 100 general practices in East Anglia between November 1995 and March 1996, evaluated whether education could change doctors' management.3 Practices reported individual cases, and behaviour of practices receiving education was compared with that in control practices. There were differences in the numbers reported from practices, raising concerns that underreporting might impact on the result. The publication of an Effective Health Care bulletin on menorrhagia coinciding with the start of the study was also a potential confounder.4 Furthermore, the reported data allowed comparison only between the two study groups and did not allow assessment …
Accreditation Standards and House-Staff Teaching
Authors: RUDOLPH J. NAPODANO
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 May 1977Accreditation Standards and House-Staff TeachingRUDOLPH J. NAPODANO, M.D.RUDOLPH J. NAPODANO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-5-653_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The Board of Commissioners of the Joint Commission on Hospital Accreditation recently adopted changes in the wording of Standard VII of the Medical Staff Section: "Where there is a medical staff policy that permits patient care orders to be written by the house staff, the policy must not be extended to prohibit orders being written by the patient's private physician without his agreement. This should be made clear in the medical staff by-laws, rules and regulations" (1). This standard does protect the rights and privileges of the medical attending staff and also, seemingly, those of the patient....Reference1. : Perspectives on accreditation. March-April 1976, no. 2 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1977Volume 86, Issue 5Page: 653-653KeywordsMedical staffPatient advocacyPatients Issue Published: 1 May 1977 PDF DownloadLoading ...
Etiology of the Severe Form of Idiopathic Hypercalcemia of Infancy
Authors: Francis X. Fellers, Robert Schwartz
Journal: New England Journal of Medicine (1958)

WITHIN the past deeade, a new syndrome has been described by Fanconi et al.1 in infants showing retardation of growth. Mental retardation, renal dysfunction and osteosclerosis, in addition to dwarfism, characterize this clinical entity, and hypercalcemia, hypercalciuria and azotemia are the major biochemical abnormalities.At about the same time, Lightwood2 , 3 reported a large series of infants showing idiopathic hypercalcemia in whom failure to thrive, anorexia, vomiting and constipation were often associated with thirst and polyuria. Hypercalcemia and azotemia were also found in these infants, but osteosclerosis and mental retardation were not observed. In contrast to this mild, reversible form, only . . .
JEJUNOSTOMY, PRIMARY AND COMPLEMENTAL
Authors: A. I. MacKINNON
Journal: JAMA (1928)

Distention is the symptom that demands immediate attention in late cases of obstruction of the bowels, whether the cause is mechanical, inflammatory or disturbed innervation. The more distended the abdomen is, the more serious the condition. If distention is relieved, the patient is in the safety zone. The operation for removing the cause may be done later when the patient's condition warrants. This plan of treating obstruction of the bowels by a two stage operation may be likened to the plan of treating prostatic obstruction first by draining the bladder and later by removing the cause. There are two outstanding reasons for the mortality of obstruction of the bowels: First, the operation is done under ether anesthesia, whether it is a simple enterostomy or an operation to relieve the obstruction, together with an enterostomy. Ether narcosis practically inhibits peristalsis for thirty or forty hours. It is strange that a surgeon
Resistin, Obesity, and Insulin Resistance — The Emerging Role of the Adipocyte as an Endocrine Organ
Authors: A R Shuldiner, R Yang, D W Gong
Journal: New England Journal of Medicine (2001)

One hundred years ago, type 2 diabetes mellitus was considered a rare disease, but recently there has been an explosive increase in its incidence. About 16 million Americans have type 2 diabetes,1 and at least an equal number have impaired glucose tolerance. Insulin resistance and hyperinsulinemia are characteristics of both type 2 diabetes and impaired glucose tolerance. These metabolic derangements, combined with the hypertension and dyslipidemia that are common in type 2 diabetes and impaired glucose tolerance, markedly increase the risk of cardiovascular, peripheral vascular, and cerebrovascular disease.Why has the incidence of type 2 diabetes increased so rapidly? Considerable . . .
Reticulated White Lip
Authors: Robert H. Dailey
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgical treatment of ventricular tachycardia after surgical repair of tetralogy of Fallot. Relation between intraoperative mapping and histological findings.
Authors: T Misaki, M Tsubota, G Watanabe, Y Watanabe, Y Matumoto, K Ishida, T Iwa, R Okada
Journal: Circulation (1994)

The mechanism of ventricular tachycardia (VT) after correction of tetralogy of Fallot (TF) is poorly understood. The purpose of this study was to examine the histopathology of the arrhythmogenic area detected by intraoperative mapping.The patients were three men who underwent radical surgery for TF at age 3, 3, or 5 years, respectively. VT developed at 8, 9, or 11 years, respectively, after surgery, and shock developed during VT in every case. The ECG revealed monomorphic VT in two cases and polymorphic VT in one case. Induction of VT resulted in a wide left-axis deviation-pattern QRS with cycle lengths varying between 260 and 330 milliseconds. The VT origin was identified at the right ventricular outflow tract (RVOT). A radical operation was performed with the patient under cardiopulmonary bypass. On epicardial mapping, delayed activation of the RVOT was recorded during sinus rhythm, and clockwise circus movement of the macroreentry current during VT on the right ventricular free wall was documented in each case. The VTs were treated successfully by surgical resection and cryoablation of the myocardium. In every patient, histology of the myocardial specimens showed degeneration, adiposis, fibrosis, inflammatory cell infiltration, and scattered myocyte islets. These lesions corresponded anatomically to the area of myocardium in which delayed activation was evident during epicardial mapping.The results of this study indicate that patients with VT after radical correction of the TF have abnormal histopathological findings at the site of the prior right ventriculotomy scar. These lesions were noted within the region of delayed activation found during epicardial mapping and were found to be a part of the reentrant circuit.
Alterations in myocardial creatinine kinase (CK) and lactate dehydrogenase (LDH) isoenzyme‐distribution in a model of left ventricular dysfunction
Authors: Frank Muders, Stefan Neubauer, Andreas Luchner, Sabine Fredersdorf, Guntram Ickenstein, Günter A.J. Riegger, Michael Horn, Dietmar Elsner
Journal: European Journal of Heart Failure (2001)
ARSENIC IN ITS RELATION TO THE KERATIN TISSUES
Authors: S. Smith, E. B. Hendry
Journal: BMJ (1934)

L MEDICAL,TOIJRNAL degree of the contractions and relaxations'Lcan be so con- trolled that the origin and insertion of the muscle need not be approximated until desired; consequently, the beneficial physiological changes called into activity by mnuscle action are produced with the minimal amount of strain of its fibres, and the movements of the injured joint as a whole can be kept within minimal range.If treatment is based on these principles no uncomplicated acute sprain should become a chronic one.
The Origin and Seat of Epileptic Disturbance
Authors: C. Mercier
Journal: BMJ (1892)

dition of the mucous membrane of the intestine, which acts on its secretive power and induces a hypersecretion of mucus and thus produces the alternations of diarrhoea and constipa tion which Niemeyer has so well studied.The cerebro-spinal system appears also to play an important part in the production of these symptoms.The remarkable sedative effects produced by the waters of Plombieres confirm this view.A hypochondriacal tendency and all the various symptoms described under the name of neurasthenia are frequent concomitants of this affection.During twenty years of practice at Plombiores I have treated no fewer than 4,500 patients affected with gastro-enteric troubles, whether of the nature of gastric dyspepsia, of enteritis, of intestinal atony, or chronic diarrhoea.Of this number of patients I find that no fewer than 460 were affected with glairy enteritis, an affection which, I have already said, should not be confounded with colitis or dysentery.Women are more subject to this affection than men.I find 250 cases of women, 150 of men, and 60 of children.Almost
Carrier detection in families with properdin deficiency by microsatellite haplotyping.
Authors: K Kölble, A J Cant, A C Fay, K Whaley, M Schlesinger, K B Reid
Journal: Journal of Clinical Investigation (1993)

Human properdin deficiency is an X-linked disorder strongly predisposing to meningococcal disease which has been recorded in over 50 cases of various ethnic origins. Immunochemically, total deficiency (type I), partial deficiency (type II), and deficiency due to a dysfunctional molecule (type III) can be differentiated. It is therefore most likely that the causative molecular defects will show considerable genetic heterogeneity. Analysis of the properdin locus at Xp11.3-Xp11.23 has led to the characterization of two polymorphic (dC-dA)n.(dG-dT)n repeats located approximately 15 kb downstream from the structural gene. Three families (two Scottish Caucasoid, one Tunisian Sephardic) with seven deficient individuals were investigated immunochemically and using a nonradioisotopic polymerase chain reaction-based method for microsatellite detection. Probable and definite carriers frequently showed properdin levels which were in the normal range. No recombinants between the microsatellite loci and properdin deficiency were detected, thus allowing identification of the defective allele through the generations in all three pedigrees. Haplotyping for these highly polymorphic microsatellites in close physical linkage to the properdin gene can provide rapid and nonradioactive detection of carrier status and prenatal diagnosis without extensive sequencing analysis.
Uremic Cardiomyopathy in Patients on a Selected Low Protein Diet.
Authors: Constantine L. Hampers
Journal: Annals of Internal Medicine (1967)

s1 May 1967Uremic Cardiomyopathy in Patients on a Selected Low Protein Diet.Constantine L. Hampers, M.D., George L. Bailey, M.D., John P. Merrill, M.D., F.A.C.P.Constantine L. Hampers, M.D.Search for more papers by this author, George L. Bailey, M.D.Search for more papers by this author, John P. Merrill, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1050_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of a low-protein diet for the treatment of severe uremia has been resurrected recently with gratifying results. It has prolonged the useful existence of many patients and has been particularly effective in controlling the gastrointestinal manifestations of renal failure. Not all systems are favorably affected, however, and we have noted the progression of a peculiar cardiomyopathy in 5 of 35 patients who were maintained on the "diet" from 1 to 10 months. The clinical picture is one of a progressive, severe biventricular failure manifested by [1] massive cardiomegaly, [2] gallop rhythm, [3] afallin mean blood pressure,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1050-1050KeywordsBlood pressureCardiomyopathiesDietFallsProteinsRenal failure Issue Published: 1 May 1967 PDF DownloadLoading ...
575 ALTERATION IN LIPID AND GLUCOSE (INSULIN SIGNALING PATHWAY) METABOLISM-RELATED GENE EXPRESSION IN HEPATOCELLULAR CARCINOMA HAS IMPLICATIONS FOR TREATMENT USING LIPID MODULATORS
Authors: M. Nakamuta, R. Yada, A. Taketomi, M. Yada, T. Yoshimoto, N. Fukushima, K. Fukuizumi, Y. Maehara, H. Nomura, M. Enjoji
Journal: Journal of Hepatology (2010)
Recent advances: Cardiology
Authors: K. K Teo
Journal: BMJ (1998)

Important advances are being made in acute ischaemic syndromes, chronic coronary artery disease, congestive heart failure, and sudden cardiac death. This review highlights some of the advances in cardiology and the resultant changes in clinical practice that are taking place.

For this review, I have used data from published literature and information on ongoing trials obtained from colleagues. Since doctors usually look to clinical trials to guide their practices, I discuss recent important clinical trials (for explanation of study acronyms see box on BMJ website at www.bmj.com). I also used data from, and systematic overviews of, randomised clinical trials where available.

Acute myocardial infarction and unstable angina are the main reasons for hospitalisation. Pathophysiologically, treatment focuses on the intracoronary thrombosis. Thrombolysis has been clearly shown to be efficacious and is widely used in acute myocardial infarction but is unproved in treating unstable angina. Adjunctive treatment with new antiplatelet and antithrombin agents are being investigated.

### Platelet glycoprotein IIb/IIIa inhibition

Interest in the role of platelets in forming the thrombus has led to identification of the platelet surface glycoprotein IIb/IIIa complex, which, when activated by exposure to ADP or thrombin, binds fibrinogen and links platelets into large aggregates.1 Inhibitors of this complex, a member of the integrin family of adhesion receptors mediating the final common pathway in platelet aggregation, have been evaluated in the acute ischaemic syndromes and after coronary angioplasty. One such inhibitor is a mouse monoclonal antibody, known as 7E3 or abciximab. When given to patients with evolving acute myocardial infarction or unstable angina who are undergoing coronary angioplasty, this agent has produced remarkable reductions in acute myocardial infarction and need for urgent revascularisation in the 30 days after the procedure and beyond (table 1).2-5

### Recent advances

Inhibitors of the platelet surface glycoprotein IIb/IIIa complex are promising treatments for acute ischaemic syndromes in …
Child psychiatry and the general practitioner; diagnosis and treatment of emotional diseases of childhood.
Authors: Alejandro Rodriguez
Journal: JAMA (1963)

This 196-page, comprehensively written book, with a great deal of material in a limited space, presents many theoretical and practical concepts concerning the management of emotionally disturbed children. This book has the advantage of revealing the multidisciplinary aspects of a child-guidance clinic.  The manner in which psychosomatic disorders in children are presented is quite realistic. The chapters entitled the Psychotic Child, Neurosis in Childhood, Recognition and Management of Mental Retardation, Community Health Aspect of Hospitalization, and the summary of the psychopharmacological agents provide an excellent introduction for these problems. There is a well-selected bibliography useful for the medical practitioner.
Estimation of infarct size by myocardial emission computed tomography with thallium-201 and its relation to creatine kinase-MB release after myocardial infarction in man.
Authors: S Tamaki, H Nakajima, T Murakami, Y Yui, H Kambara, K Kadota, A Yoshida, C Kawai, N Tamaki, T Mukai, Y Ishii, K Torizuka
Journal: Circulation (1982)

We evaluated emission computed tomography (ECT) for thallium-201 (201TI) myocardial imaging in estimating infarct size (IS). In 18 patients in whom IS was estimated enzymatically at the time of the acute episode, planar 201TI perfusion scintigraphy and ECT with a rotating gamma camera were performed 4 weeks after the first myocardial infarction. From the size of 201TI perfusion defects, the infarct area in planar images and the infarct volume in reconstructed ECT images were measured by computerized planimetry. When scintigraphic IS was compared with the accumulated creatine kinase-MB isoenzyme release (CK-MBr), infarct volume determined from ECT correlated closely with CK-MBr (r = 0.89), whereas infarct area measured from planar images correlated less satisfactorily with the enzymatic IS (for an average infarct area from three views, r = 0.69; for the largest infarct area, r = 0.73). Although conventional scintigraphic evaluation is useful for detecting and localizing infarction, quantification of ischemic injury with this two-dimensional technique has a significant inherent limitation. The ECT approach can provide a more accurate three-dimensional quantitative estimate of infarction, and can corroborate the enzymatic estimate of IS.