Therapeutic Plasma Exchange
Authors: Fadi Fakhouri, François Vincent, Christophe Legendre
Journal: Annals of Internal Medicine (2000)

Letters2 May 2000Therapeutic Plasma ExchangeFadi Fakhouri, MD, François Vincent, MD, and Christophe Legendre, MDFadi Fakhouri, MDHôpital Saint-Louis; 75010 Paris, France (Fakhouri)Hôpital Saint-Louis; 75010 Paris, France (Vincent)Hôpital Saint-Louis; 75010 Paris, France (Legendre)Search for more papers by this author, François Vincent, MDHôpital Saint-Louis; 75010 Paris, France (Fakhouri)Hôpital Saint-Louis; 75010 Paris, France (Vincent)Hôpital Saint-Louis; 75010 Paris, France (Legendre)Search for more papers by this author, and Christophe Legendre, MDHôpital Saint-Louis; 75010 Paris, France (Fakhouri)Hôpital Saint-Louis; 75010 Paris, France (Vincent)Hôpital Saint-Louis; 75010 Paris, France (Legendre)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-9-200005020-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As Clark and colleagues (1) indicate, the use of plasma exchange for thrombotic thrombocytopenic purpura (TTP) has drastically increased following the results of Rock and associates' prospective study (2), which indicated that plasma exchange is more efficacious than plasma infusion for TTP. However, the validity of the results of this study can be questioned because the plasma exchange group and plasma infusion group differed in terms of total plasma volume infused and duration of therapy. Moreover, plasma exchange performed with albumin or saline usually fails to induce TTP remission (3). This suggests that plasma infusion rather than ...References1. Clark WF, Rock GA, Buskard N, Shumak KH, LeBlond P, Anderson D, et al . Therapeutic plasma exchange: an update from the Canadian Apheresis Group. Ann Intern Med. 1999;131:453-62. LinkGoogle Scholar2. Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, et al . Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. N Engl J Med. 1991;325:393-7. CrossrefMedlineGoogle Scholar3. Ruggenenti P, Galbusera M, Cornejo RP, Bellavita P, Remuzzi G. Thrombotic thrombocytopenic purpura: evidence that infusion rather than removal of plasma induces remission of the disease. Am J Kidney Dis. 1993;21:314-8. CrossrefMedlineGoogle Scholar4. Patton JF, Manning KR, Case D, Owen J. Serum lactate dehydrogenase and platelet count predict survival in thrombotic thrombocytopenic purpura. Am J Hematol. 1994;47:94-9. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Fadi Fakhouri, MD; François Vincent, MD; Christophe Legendre, MDAffiliations: Hôpital Saint-Louis; 75010 Paris, France (Fakhouri)Hôpital Saint-Louis; 75010 Paris, France (Vincent)Hôpital Saint-Louis; 75010 Paris, France (Legendre) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTherapeutic Plasma Exchange: An Update from the Canadian Apheresis Group William F. Clark , Gail A. Rock , Noel Buskard , Kenneth H. Shumak , Pierre LeBlond , David Anderson , David M. Sutton , and Therapeutic Plasma Exchange William F. Clark , Gail Rock , and Kenneth A. Shumak Metrics Cited byTime course of organ dysfunction in thrombotic microangiopathy patients receiving either plasma perfusion or plasma exchange*ADAMTS13 and thrombotic thrombocytopenic purpura-hemolytic uremic syndrome 2 May 2000Volume 132, Issue 9Page: 760KeywordsAlbuminsBlood plasmaBody weightLactate dehydrogenasePlasma volumePlateletsProspective studiesThrombotic thrombocytopenic purpura ePublished: 15 August 2000 Issue Published: 2 May 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...