tbuckley/cabot-search huggingface dataset:
The coexistence of cutaneous vasculitis and thrombosis in childhood-onset systemic lupus erythematosus with antiphospholipid antibodies
Authors: K. Tomizawa, K.C. Sato-Matsumura, N. Kajii
Journal: British Journal of Dermatology (2003)

Journal Article The coexistence of cutaneous vasculitis and thrombosis in childhood‐onset systemic lupus erythematosus with antiphospholipid antibodies Get access K. Tomizawa, K. Tomizawa Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar K.C. Sato‐Matsumura, K.C. Sato‐Matsumura Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan E‐mail: tomizawa@hosp.city.ebetsu.hokkaido.jp Search for other works by this author on: Oxford Academic Google Scholar N. Kajii N. Kajii Paediatrics, Ebetsu City Hospital, 6 Wakakusa‐Cho, Ebetsu 067‐8585, and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 2, 1 August 2003, Pages 439–441, https://doi.org/10.1046/j.1365-2133.2003.05459.x Published: 01 August 2003
Measurement of back movement.
Authors: I F Macrae, V Wright
Journal: Annals of the Rheumatic Diseases (1969)

Both tests were applied to the population under survey, comprising probands with ulcerative colitis, and their relatives and spouses, a total of 195 females and 147 males.The results were correlated with sex, age, and the clinical condition.In a selected group, height and weight were measured and their effect observed.
CLINICAL EVALUATION OF AZACYCLONOL, CHLORPROMAZINE, AND RESERPINE ON A GROUP OF CHRONIC PSYCHOTIC PATIENTS
Authors: FRANCO RINALDI, L H. RUDY, H. E. HIMWICH
Journal: American Journal of Psychiatry (1956)

1. Clinical evaluations of azacyclonol, reserpine, and chlorpromazine were made in turn on the same group of chronic, moderately disturbed, psychotic patients, most of whom revealed schizophrenic reactions maintained through long hospitalization. 2. Beneficial results were obtained with each of the 3 drugs, but not necessarily in the same patients; nor were all patients helped by any one drug. 3. Consideration of the total number of patient improvements in our limited series showed reserpine to be best, closely followed by chlorpromazine, and then by azacyclonol. 4. From the analysis of the results in relation to the different diagnostic categories, it would seem that the hebephrenic and hebephreno-catatoonic patients were helped most by reserpine, next came azacyclonol, while chlorpromazine was least effective. In the treatment of paranoid patients chlorpromazine was most beneficial, followed by reserpine, and then by azacyclonol. The schizo-affective patients exhibited best improvement with chlorpromazine. One case of involutional depression was strikingly benefited by reserpine. 5. Limiting the validity of these conclusions to the types of patients studied we find that it is possible to differentiate between the use of each of these drugs in different psychiatric categories and to indicate the choice of drug that may prove most useful in the treatment of a given case.
Homoeopathy: medicine or magic?
Authors: N. Gould
Journal: BMJ (1991)

guidelines laid down for the profession to follow, and this certainly is an area where public participation and debate must be provided.Nor may the cost-benefit ratio be the only test that is relevant.Some may want to consider the age of the patient, as is done with renal dialysis in Britain.Others may attach weight to the contribution patients make to society or the degree to which they were responsible for their illness.Should haemophiliacs with HIV infection and AIDS be treated any differently from others with the conditions?Should confirmed alcoholics be given an expensive liver transplant if they refuse to give up drink?In Oregon the public expressed interest in 13 social values, but only a few will be incorporated in the process and no one knows yet how it will be done.There remains the problem of deciding how resources should be allocated.Professor Klein is right to stress the need for public and professional involvement, but this will not make the decision process any easier.Many views will be expressed and health authorities will still have the task of reconciling conflicting priorities.Nor can they ignore political realities.Internal market or not, the acute sector is likely to retain the lion's share of funds with the largest amounts still going to the most powerful specialties-those producing the most revenue.If groups like the mentally ill are to be justly treated then central direction combined with ring fenced financing will be needed.Butthe whole process would be greatly facilitated if the NHS were adequately funded.Rationing and resource allocation will be seen to be fair only when Britain devotes as much of its gross national product to health care as does the rest of the European Community.
Futility: Another Way?
Authors: Keyvan Ravakhah
Journal: Annals of Internal Medicine (2014)

Letters17 June 2014Futility: Another Way?Keyvan Ravakhah, MD, MBAKeyvan Ravakhah, MD, MBAFrom St. Vincent Charity Center, Cleveland, Ohio.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5012-7 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Shah's story on futility (1) misleads readers to believe that surrendering to an unreasonable request made by the daughter of a dying patient, under the guise of “giving hope,” is acceptable. He seemed to forget whose physician he was, subjecting a terminally ill patient to extensive surgery, bowel resection, and open abdomen only to have her die a few days later. Shah's responsibility should have been to help his dying patient and not a family member in desperate need of support that he apparently could not provide. It is also painfully surprising to see that the person ...References1. Shah SK. Futility. Ann Intern Med. 2014;160:138-9. [PMID: 24592501] LinkGoogle Scholar2. Clayton JM, Butow PN, Arnold RM, Tattersall MH. Discussing life expectancy with terminally ill cancer patients and their carers: a qualitative study. Support Care Cancer. 2005;13:733-42. [PMID: 15761699] CrossrefMedlineGoogle Scholar3. Christakis NA, Lamont EB. Extent and determinants of error in doctors' prognoses in terminally ill patients: prospective cohort study. BMJ. 2000;320:469-72. [PMID: 10678857] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Keyvan Ravakhah, MD, MBAAffiliations: From St. Vincent Charity Center, Cleveland, Ohio.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0191. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFutility Samir K. Shah Futility Samir K. Shah Futility: Another Way? Joanne Lynn Futility: Another Way? Steven M. Radwany Futility: Another Way? Simon Kassabian Futility: Another Way? Samir K. Shah Futility: Another Way? Samir K. Shah Futility: Another Way? Joanne Lynn Futility: Another Way? Simon Kassabian Futility: Another Way? Steven M. Radwany Metrics 17 June 2014Volume 160, Issue 12Page: 878-879KeywordsColectomyConflicts of interestDisclosureHealth carePalliative careSurgery ePublished: 17 June 2014 Issue Published: 17 June 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Dynamic Electrocardiographic Concept Useful in the Diagnosis of Cor Pulmonale
Authors: MARGARET M. KILCOYNE, ANNE L. DAVIS, M. IRENÉ FERRER
Journal: Circulation (1970)

The results of a survey of 200 patients with chronic obstructive pulmonary disease (COPD) revealed that the electrocardiographic criteria used in the past are relatively poor delineators of cor pulmonale in COPD, either in its early or late stages. The study offers a dynamic concept designed to aid in discovering right ventricular (RV) complications in COPD-the coupling of arterial blood gas analysis and four electrocardiographic fluctuations which signal RV abnormality. Where arterial O 2 saturation fell below 85% and pulmonary artery mean pressure (PA m ) was 25 mm Hg or greater, one or more of these four fluctuations were seen in patients with cor pulmonale: (1) a rightward shift of the mean QRS axis of 30° or more; (2) T-wave abnormalities in right V leads; (3) ST depressions in leads II, III, and aV F ; and (4) transitory right bundle-branch block. With recovery of better arterial saturation and decrease in PA m they subsided. Thus, a clinical appraisal of patients with COPD should include serial analyses of arterial blood gas plus serial electrocardiograms if early (and hence reversible) RV abnormality and cor pulmonale are to be uncovered.
PUERPERAL ECLAMPSIA AND ITS TREATMENT.
Authors: J. T. McSHANE
Journal: JAMA (1896)

9.-The solubility and consequently superior pene- trability of the bichlorid is probably productive of the mercurial characteristic, effects which seem out of proportion to the amount of metal in doses of this salt; but it is not to be denied that chemic or direct neurotic influences cooperate with the metal in the more active preparations, and thus possess features of their own.10.-Experimental evidence is opposed to probable formation of any compound in the body, and supports the belief that decomposition invariably and almost instantaneously follows its ingestion with the pre- cipitation of mercury as minutely divided globules, from any preparation of which it forms the base. PUERPERAL ECLAMPSIA AND ITSTREATMENT.Read before the Marion County (Iud.)Medical Society.
Phospholipase Cβ Serves as a Coincidence Detector through Its Ca2+ Dependency for Triggering Retrograde Endocannabinoid Signal
Authors: Yuki Hashimotodani, Takako Ohno-Shosaku, Hiroshi Tsubokawa, Hidenori Ogata, Ken Emoto, Takashi Maejima, Kenji Araishi, Hee-Sup Shin, Masanobu Kano
Journal: Neuron (2005)
Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus
Authors: Geoffrey A. Walford, Jaclyn Davis, A. Sofia Warner, Rachel J. Ackerman, Liana K. Billings, Bindu Chamarthi, Rebecca R. Fanelli, Alicia M. Hernandez, Chunmei Huang, Sabina Q. Khan, Katherine R. Littleton, Janet Lo, Rita M. McCarthy, Eugene P. Rhee, Amy Deik, Elliot Stolerman, Andrew Taylor, Margo S. Hudson, Thomas J. Wang, David Altshuler, Richard W. Grant, Clary B. Clish, Robert E. Gerszten, Jose C. Florez
Journal: Metabolism (2013)
Understanding Low Sugar from NICE-SUGAR
Authors: Irl B. Hirsch
Journal: New England Journal of Medicine (2012)

A 2001 study from a single center in Leuven, Belgium, in which intensive insulin therapy was associated with a relative reduction in the risk of death of 42% among patients in the surgical intensive care unit (ICU) drew unprecedented attention to the degree of inpatient glycemic control in very ill patients.1 Replication and translation from the research setting has proved difficult, however, and although near-euglycemia in the ICU has become widely recommended, especially for surgical patients,2 it is clear that this therapy is not effective for all patient populations. Indeed, one study of tight glucose control was prematurely terminated owing . . .
THE TRANSMISSION OF YELLOW FEVER
Authors: Nelson C. Davis
Journal: The Journal of Experimental Medicine (1930)

1. Saimiri sciureus has been infected with yellow fever virus, both by the inoculation of infectious blood and by the bites of infective mosquitoes. Some of the monkeys have died, showing lesions, including hepatic necrosis, suggesting yellow fever as seen in human beings and in rhesus monkeys. Virus has been transferred back to M. rhesus from infected Saimiri both by blood inoculation and by mosquito bites. The virus undoubtedly has been maintained through four direct passages in Saimiri. Reinoculations of infectious material into recovered monkeys have not given rise to invasion of the blood stream by virus. Sera from recovered animals have protected M. rhesus against the inoculation of virus. 2. It has been possible to pass the virus to and from Ateleus ater by the injection of blood or liver and by the bites of mosquitoes. The livers from two infected animals have shown no necrosis. The serum from one recovered monkey proved to be protective for M. rhesus. 3. Only three out of twelve Lagothrix lagotricha have reacted to yellow fever virus by a rise in temperature. Probably none have died as a result of the infection. In only one instance has the virus been transferred back to M. rhesus. The sera of recovered animals have had a protective action against yellow fever virus.
Some Adrenergic Drugs and Atropine Methonitrate Given by Inhalation for Asthma: A Comparative Study
Authors: M. C. S. Kennedy, D. C. Thursby-Pelham
Journal: BMJ (1964)

Since Barger and Dale (1910) described the chemical struc ture and sympathomimetic action of adrenaline-like amines, adrenaline and adrenergic drugs have been extensively used for the treatment of asthma. Adrenaline itself is active only when it is given parenterally or by inhalation, whereas the more recently introduced isoprenaline is more stable and can be given by inhalation or as a sublingual tablet, though it is not suitable for parenteral use. Over the past two decades the number of inhalants that have been available for the treatment of asthma has increased enormously. They consist basically of adrenaline or isoprenaline ; many proprietary brands also contain other ingredients?for example, atropine sulphate, atropine methonitrate, benzocaine, papaverine, posterior pituitary extract, stramonium, as well as other trace ingredients.
An extra dose of rituximab improves clinical response in rheumatoid arthritis patients with initial incomplete B cell depletion: a randomised controlled trial
Authors: Edward M Vital, Shouvik Dass, Maya H Buch, Andrew C Rawstron, Paul Emery
Journal: Annals of the Rheumatic Diseases (2014)

Since clinical non-response to 2×1000 mg rituximab has previously been found to be associated with incomplete B cell depletion, we determined, in a randomised controlled proof of concept study, whether patients with initial incomplete B cell depletion would benefit from an additional infusion of rituximab at week 4.Patients with active rheumatoid arthritis despite methotrexate received a first infusion of rituximab 1000 mg and were tested for persistent B cells using highly sensitive flow cytometry on day 15. All received a second infusion of 1 g (according to license), but patients with persistent B cells were subsequently randomised double-blind to receive, 2 weeks later, either a third infusion of 1000 mg rituximab or placebo. Clinical response was determined by European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR) criteria.Baseline characteristics were balanced between groups. Treatment with 3×1000 mg rituximab resulted in significantly greater depletion (lower B cell and plasmablast numbers between 8 and 28 weeks) paralleled by significantly better EULAR and ACR20 response rates at 40 weeks (p=0.035 and p=0.027, respectively) and 52 weeks (p=0.021 and p=0.043, respectively) compared with 2×1000 mg. Immunoglobulin titres remained stable in both arms, and adverse event rates were balanced.In rituximab-treated patients with incomplete B cell depletion (predictive of poor response), an extra 1000 mg infusion of rituximab at 4 weeks produced both better depletion and clinical responses than placebo with no worsening of safety. Degree of depletion is an important, but modifiable, determinant of response.
Principles of Appropriate Antibiotic Use for Treatment of Acute Respiratory Tract Infections in Adults: Background, Specific Aims, and Methods
Authors: Ralph Gonzales, John G. Bartlett, Richard E. Besser, Richelle J. Cooper, John M. Hickner, Jerome R. Hoffman, Merle A. Sande
Journal: Annals of Internal Medicine (2001)

The need to decrease excess antibiotic use in ambulatory practice has been fueled by the epidemic increase in antibiotic-resistant Streptococcus pneumoniae. The majority of antibiotics prescribed to adults in ambulatory practice in the United States are for acute sinusitis, acute pharyngitis, acute bronchitis, and nonspecific upper respiratory tract infections (including the common cold). For each of these conditions—especially colds, nonspecific upper respiratory tract infections, and acute bronchitis (for which routine antibiotic treatment is not recommended)—a large proportion of the antibiotics prescribed are unlikely to provide clinical benefit to patients. Because decreasing community use of antibiotics is an important strategy for combating the increase in community-acquired antibiotic-resistant infections, the Centers for Disease Control and Prevention convened a panel of physicians representing the disciplines of internal medicine, family medicine, emergency medicine, and infectious diseases to develop a series of "Principles of Appropriate Antibiotic Use for Treatment of Acute Respiratory Tract Infections in Adults." These principles provide evidence-based recommendations for evaluation and treatment of adults with acute respiratory illnesses. This paper describes the background and specific aims of and methods used to develop these principles. The goal of the principles is to provide clinicians with practical strategies for limiting antibiotic use to the patients who are most likely to benefit from it. These principles should be used in conjunction with effective patient educational campaigns and enhancements to the health care delivery system that facilitate nonantibiotic treatment of the conditions in question.
Electrical correlate of circumferential contractions in human colonic circular muscle.
Authors: J D Huizinga, W E Waterfall
Journal: Gut (1988)

The role of myogenic electrical activity in the coordination of circumferential contraction of the human colon circular muscle was investigated. Five suction electrodes were placed (5-7 mm apart) on isolated rings of human colon and simultaneously electrical and motor activities were measured. In normal Krebs solution, the slow waves were not synchronised in most preparations studied. The electrical activities at the different recording sites were different with respect to slow wave frequency and amplitude, and amount of spiking activity. This resulted in irregular contractile activity. Cholinergic stimulation resulted in the development of a specific pattern of electrical activity: periodic slow wave activity with superimposed spiking activity which was synchronised over the length of the segment studied. This synchronised electrical activity resulted in regular phasic contractions at the frequency of the bursts of electrical activity (approximately 1/min). The response to carbachol was mediated by muscarinic receptors since it was blocked by atropine. The periodic activity in the continuous presence of carbachol was not the result of periodic input of neural activity as it occurred in the presence of TTX. Intrinsic properties of the muscle cells were responsible for the carbachol induced pattern of activity. The present study presents evidence that the electrical correlate of circumferential contractions is different in man compared with the most commonly studied animal models. It is a specific, stimulus induced pattern of myogenic activity. Its characteristics closely resemble those of a particular pattern of in vivo recorded activity referred to as the 9long spike bursts9.
Peak Petroleum and Public Health
Authors: Howard Frumkin, Jeremy Hess, Stephen Vindigni
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ian Stanley Berg
Authors: P. Graham
Journal: BMJ (2009)

<h3>Objectives</h3> To examine mortality from digestive cancers in a Chinese miner cohort and to explore the exposure–response relationship between chrysotile mining dust and site-specific digestive cancers. <h3>Methods</h3> A cohort of 1539 asbestos miners was followed for 26 years. Information on vital status and death causes was collected from personnel records and hospitals. Underlying causes of death from cancers were determined by combination of clinical manifestations and pathological confirmation. Individual cumulative dust exposures were estimated based on periodic dust measurements of different workshops, individuals’ job title and employment duration, and treated as a time-dependent variable. Standardised mortality ratios (SMR) were calculated according to Chinese national data and stratified by exposure (levels 1–3, from low to high). Cox proportional hazard models were constructed to estimate HRs in relation to cumulative exposure with adjustment of smoking. <h3>Results</h3> Fifty-one deaths from digestive cancers were identified in the cohort, giving an SMR of 1.45 (95% CI 1.10 to 1.90). There was a clear exposure–response relationship between asbestos dust exposure and mortality from stomach cancer, with SMR of 2.39 (95% CI 1.02 to 5.60) and 6.49 (2.77 to 15.20) at exposure levels 2 and 3, respectively. The clear relationship remained in multivariate analysis, in which workers at the highest exposure level had HRs of 12.23 (95% CI 8.74 to 17.12). In addition, excess mortality from oesophageal and liver cancers was also observed at high exposure levels. <h3>Conclusions</h3> This study provides additional evidence for the association between exposure to chrysotile mining dust and excess mortality from digestive cancers, particularly stomach cancer.
Relevance of ara h1, ara h2, and ara h3 in peanut allergic patients, as determined by IgE-western-blotting, basophil histamine release, and intracultaneous testing: Ara h2 is the most important peanut allergen
Authors: E.F. Knol, M. Wensing, R. Vlooswijk, M. Ertmann, A.C. Knulst, S.J. Koppelman
Journal: Journal of Allergy and Clinical Immunology (2003)
Spleen scanning as a diagnostic tool
Authors: B. Felson
Journal: JAMA (1977)

THE WIDE range of functions carried out by the spleen (Table) means that disorders can occur in almost all age groups. To the physician evaluating patients with splenomegaly, hemolytic anemia, or other signs or symptoms relating to the spleen, the number of tests available may appear rather formidable. However, after an adequate history, physical examination, and hematologic study, a spleen scan may be the procedure of choice in the majority of cases. The splenic function that can be most readily assessed by use of radiopharmaceuticals is the ability of its reticuloendothelial (RE) cells to accumulate intravenously administered particulates. When colloidal gold (gold Au 198, particle size 0.001μ to 0.01μ) was used as a liver-scanning agent, nearly all of the agent was accumulated by the liver. Only when there was hepatic damage, such as cirrhosis or hepatitis, was the gold radiocolloid taken up by spleen and bone marrow RE cells. However,