tbuckley/cabot-search huggingface dataset:
Low dose azaribine in the treatment of psoriasis
Authors: PAUL I. DANTZIG, BERNARD McEVOY, JACQUELINE MAURO, SYRUS RAYHANZADEH
Journal: British Journal of Dermatology (1974)

Journal Article Low dose azaribine in the treatment of psoriasis Get access PAUL I. DANTZIG, PAUL I. DANTZIG Department of Dermatology, Albany Medical Center, Albany, New York, U. S. A Search for other works by this author on: Oxford Academic Google Scholar BERNARD McEVOY, BERNARD McEVOY Department of Dermatology, Albany Medical Center, Albany, New York, U. S. A Search for other works by this author on: Oxford Academic Google Scholar JACQUELINE MAURO, JACQUELINE MAURO Department of Dermatology, Albany Medical Center, Albany, New York, U. S. A Search for other works by this author on: Oxford Academic Google Scholar SYRUS RAYHANZADEH SYRUS RAYHANZADEH Department of Dermatology, Albany Medical Center, Albany, New York, U. S. A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue 5, 1 November 1974, Pages 573–577, https://doi.org/10.1111/j.1365-2133.1974.tb12947.x Published: 01 November 1974 Article history Accepted: 13 February 1974 Published: 01 November 1974
Accuracy of a Filter Paper Method for Measuring Glycosylated Hemoglobin
Authors: Elizabeth C Gay, Karen J Cruickshanks, H Peter Chase, Georgeanne Klingensmith, Richard F Hamman
Journal: Diabetes Care (1992)

Objective –To compare glycosylated hemoglobin (GH) results obtained by filter paper fingerstick collection and mailed for assay by affinity chromatography with results from a venous sample assayed by ion-exchange chromatography (HbA1) in a local laboratory. Research Design and Methods –Fifty-eight volunteer subjects with insulin-dependent diabetes mellitus (IDDM), aged 5-24 yr, included patients at a referral-based IDDM clinic and subjects in an ongoing research study. We obtained two blood samples from each subject. One was collected by fingerstick onto filter paper, the other by venipuncture into a vacutainer. We sent filter paper samples to the Diabetes Research Laboratory (Univ. of Missouri, Columbia, MO) for analysis. Vacutainer samples were sent to the Clinical Chemistry Department of the Clinical Laboratory, University of Colorado Health Sciences Center. Results –Results were highly correlated (r = 0.89, P = 0.0001). Fifty-nine percent were classified identically when results were normalized to SD units and grouped to suggest levels of clinical concern. Conclusions –The filter paper method is a convenient, accurate measure of glycosylated hemoglobin in young people with IDDM. It should be considered a credible alternative research and clinical tool.
Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect
Authors: D Nelson
Journal: Hepatology (2003)

An imbalance in Th1 and Th2 cytokine production is implicated in disease progression of HCV. Our aim was to determine the effect of IL-10 administration in patients with HCV-related liver disease. Thirty patients with advanced fibrosis who had failed antiviral therapy were enrolled in a 12-month treatment regimen with SQ IL-10 given daily or thrice weekly. Liver biopsies were performed before and after therapy. Serum and PBMC were collected for HCV RNA, ALT, and functional T-cell analysis. IL-10 led to significant improvement in serum ALT (mean ALT: day 0 = 142 +/- 17 vs. month 12 = 75 +/- 10; P <.05). Hepatic inflammation score decreased by at least 2 in 13 of 28 patients (mean decrease from 4.6 +/- 0.3 to 3.7 +/- 0.3, P <.05) and 11 of 28 showed a reduction in fibrosis score (mean change from 5.0 +/- 0.2 to 4.5 +/- 0.3, P <.05). Serum HCV RNA levels increased by 0.5 log during therapy (mean HCV RNA day 0: 12.3 +/- 3.0 Meq/mL; 12 months: 38 Meq/mL; P <.05) and returned to baseline at the end of follow-up (11.0 +/- 2.4 Meq/mL). Five patients developed viral loads of greater than 120 Meq/mL and two of these developed an acute flare in serum ALT. IL-10 caused a decrease in the number of HCV-specific CD4+ and CD8+ IFN-gamma secreting T cells and alterations in PBMC cytokine production towards a Th2 dominant profile. These changes parallel the improvement in ALT and rise in HCV RNA. In conclusion, long-term rIL-10 therapy appears to decrease disease activity, but also leads to increased HCV viral burden via alterations in immunologic viral surveillance.
AN INTESTINAL OBSTRUCTION, DUE TO AN ABNORMALLY FORMED APPENDIX, ABNORMALLY LOCATED.
Authors: ANGUS McLEAN
Journal: JAMA (1898)

The patient who had this rare and unfortunate anatomic phenomenon was a man aged 40 and by occupation a foreman. He was taken with pain in the right lumbar and epigastric regions while at work; the pain was intermittent and gradually became more severe. He was compelled to quit work and go to his home. He became nauseated in a few hours and sent for his physician, Dr. Charles E. Bleakley. The Doctor examined the abdomen but found nothing of a localized character. He administered cathartics, and a slight anodyne for the pain, but the cathartics were ineffectual, and upon seeing him again he gave large doses of cathartics and had this followed by rectal enemata, but this also proved ineffectual. The pain had now become so severe as to require occasional hypodermics of morphia. The Doctor grew suspicious of obstruction and had medical counsel called, but nothing definite was
Kenneth John Gurling
Authors: H. Gurling
Journal: BMJ (2003)

Former consultant physician Derbyshire Royal Infirmary (b 1921; q King's College Hospital, London, 1945; MD, FRCP), died from heart disease on 17 June 2002.

After qualifying, Kenneth was a major in the Royal Army Medical Corps and medical director of hospitals in Somalia and the Sudan. From 1948 to 1954 he was registrar in the diabetic department at King's College Hospital, where he developed an interest in endocrinology. He then did research in Pennsylvania and London on the effects of methotrexate on tumour cells, before his appointment as consultant physician in Derby. In 1970 he became the first postgraduate dean of the new Nottingham University medical school. Predeceased by his first wife, Nora, with whom he had two children, he leaves his second wife, Monica, and three grandchildren.
A Comparison of Warfarin and Aspirin for the Prevention of Recurrent Ischemic Stroke
Authors: J.P. Mohr, J.L.P. Thompson, R.M. Lazar, B. Levin, R.L. Sacco, K.L. Furie, J.P. Kistler, G.W. Albers, L.C. Pettigrew, H.P. Adams, C.M. Jackson, P. Pullicino
Journal: New England Journal of Medicine (2001)

Despite the use of antiplatelet agents, usually aspirin, in patients who have had an ischemic stroke, there is still a substantial rate of recurrence. Therefore, we investigated whether warfarin, which is effective and superior to aspirin in the prevention of cardiogenic embolism, would also prove superior in the prevention of recurrent ischemic stroke in patients with a prior noncardioembolic ischemic stroke.
Sex steroid binding patterns in primary biliary cirrhosis complicated by hepatocellular carcinoma.
Authors: M J Iqbal, M L Wilkinson, R Williams
Journal: BMJ (1984)

Owing to recent findings of certain unusual sex steroid binding in liver disease--particularly an allosteric biphasic pattern (pattern A) unique to the serum of patients with hepatocellular carcinoma--the serum binding characteristics for 5 alpha-dihydrotestosterone were examined in serum samples from six patients with primary biliary cirrhosis who had developed hepatocellular carcinoma. In all serum samples taken after the development of tumour pattern A binding only was obtained, and in four cases in which earlier samples were also examined there was a transformation from the normal, non-specific binding pattern, or an allosteric plateau pattern seen in non-malignant liver disease (designated D and C respectively), to pattern A coincident with the rise in serum alpha fetoprotein. In one patient chemotherapy leading to a fall in alpha fetoprotein abolished pattern A binding, showing further its close association with tumour growth. The value of pattern A binding as a tumour marker in hepatocellular carcinoma warrants further study.
Systolic mechanical properties of the left ventricle. Effects of volume and contractile state.
Authors: W C Hunter, J S Janicki, K T Weber, A Noordergraaf
Journal: Circulation Research (1983)

To characterize the mechanical properties of the contracting left ventricle, we studied the changes in left ventricular systolic pressure following step-like perturbations (+/- 3 ml) in ventricular volume, using an isovolumically beating, isolated canine heart preparation. Three mechanical properties (elasticity, resistance, and a deactivation effect) were identified. The elastic property differs from the traditional parallel and series elastic elements; it is a time-varying elasticity that includes active and passive effects of volume changes. Furthermore, it could not be represented by a simple time-varying elasticity, but required a second factor to express the dependence of end-systolic elasticity on the timing of the volume step. This effect was represented by a "volume influence factor," which may arise from length-dependent activation. The resistive property appeared to be related to force-velocity behavior of the myocardium. Each mechanical property reacted characteristically to steady state changes in ventricular filling volume or contractile state produced by dobutamine (2-13 micrograms/min). Our findings indicate that elasticity was the property most sensitive to changes in contractile state; these changes increased peak isovolumetric pressure 54% on average, and raised elastic stiffness 40% above control (which was 5.1 mm Hg/ml). Changes in ventricular filling volume only prolonged, but did not alter, the level of elastic stiffness attained at peak pressure. These results support the view that elasticity--or the end-systolic pressure-volume relationship--serves in a given heart to quantify contractility. The "volume influence factor" was not affected by either filling volume or contractile state. Resistance increased in direct proportion with ventricular pressure, but this linear relation was not altered greatly by changes in contractile state or in ventricular filling volume. At 100 mm Hg, ventricular resistance averaged 0.11 mm Hg/ml per sec. Finally, deactivation was greater the later in systole a volume step was imposed, and this pattern was independent of changes in ventricular filling volume and in contractile state.
Orcipenaline in Treatment of Airways Obstruction in Chronic Bronchitis
Authors: G. Edwards
Journal: BMJ (1964)

(1940), since whenithas beenusedextensively. Although takensublingually isoprenalineisan effective bronchodilator; itisnot active when swallowed. Sinceitisrapidly metabolized itsduration of action isshort, andunpleasant side-effects may occur. For these reasonsa bronchodilator without thesedisadvantages, butwithcomparable clinical effectiveness, was sought, and orciprenaline, a chemically similar compound, was foundto fulfil thesecriteria inlaboratory animals (Engelhardt etal., 1961). Orciprenaline (alupent )isa racemic isomeric mixture differing onlyfromisoprenaline inhavingboththehydroxyl groupsofitsbenzeneringinthemeta position, whileisoprenaline hasone ofthese groups inthepara position. Spitzbarth andAlbers (1961) claimed thattachycardia and myocardial irritability withresultant arrhythmias were much less easily produced withorciprenaline thanwithisoprenaline. They alsoreportedthatorciprenaline had a longer duration of actionand causedlessintestinal upset. Beynon-Jones (1962) andDrewitt (1962) claimed satisfactory clinical response to orciprenaline 40-80mg. dailyin patients withasthmaor chronicbronchitis. Myersand Coltman(1963), ina double-blind controlled trial ingeneral practice, foundthatorciprenaline 60 mg. dailycompared favourably withephedrine hydrochloride 180mg. dailyin patients withasthma or chronic bronchitis. PlanofTrial Theinvestigations were designed to assessthetoxicity of orciprenaline, todetermine itsvalueincontrolling reversible bronchospasm or airwaysobstruction, and to assess its clinical effectiveness inrelieving wheezing inthechronic
New Drug to Treat HIV/AIDS Approved
Authors: Stuart L. Nightingale
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is Albumin Safe?
Authors: Deborah Cook
Journal: New England Journal of Medicine (2004)

The Saline versus Albumin Fluid Evaluation (SAFE) Study, reported in this issue of the Journal, 1 heralds a new era in critical care marked by the large, simple, randomized trial popularized by cardiologists. In a study of fluid resuscitation involving nearly 7000 critically ill patients, the Australian and New Zealand Intensive Care Society Clinical Trials Group addressed one of the most fundamental and contentious issues in critical care. Questions about the merits and demerits of colloids as opposed to crystalloids in the resuscitation of seriously ill patients have smoldered for decades, sparked by a meta-analysis suggesting that albumin was associated with . . .
Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex
Authors: DH Katz, M Graves, ME Dorf, H Dimuzio, B Benacerraf
Journal: The Journal of Experimental Medicine (1975)

The results of this study provide compelling evidence for the existence of the gene or genes controlling optimal T-B-cell cooperative interactions in the designated I region of the H-2 gene complex. Previously, we have speculated that the relevant gene(s) involved may well be located in this region based on several observations from our earlier work in this area (3, 5, 6). Thus, in the preceding paper, we showed that T and B cells from B10.BR and A strain mice developed effective cooperative interactions in vitro to DNP-KLH in a system identical to the one reported herein. Since these mice differ for genes in the S and D regions of H-2 but are identical for K and I region genes, we were able to localize the critical genes to the K-end of H-2.
1117 LOW-DOSE ATORVASTATIN IMPROVES DYSLIPIDEMIA AND VASCULAR FUNCTION IN PATIENTS WITH PRIMARY BILIARY CIRRHOSIS AFTER ONE YEAR OF TREATMENT
Authors: T. Stojakovic, T. Claudel, C. Putz-Bankuti, G. Fauler, H. Scharnagl, M. Wagner, H. Sourij, R.E. Stauber, K. Winkler, W. März, T.C. Wascher, M. Trauner
Journal: Journal of Hepatology (2010)
Army Treatment of Gonorrhea
Authors: JOSHUA B. GROSSMAN
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 July 1971Army Treatment of GonorrheaJOSHUA B. GROSSMAN, M.D.JOSHUA B. GROSSMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-1-135_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The position of Commanding Officer of a large dispensary in the Far East has afforded me a rich experience with venereal disease. As such, I personally see approximately a dozen cases of gonococcal urethritis daily six days a week. These strains are becoming increasingly less responsive to penicillin. Still, my cure rate has been quite high by using polycillin, kanamycin, and keflin parenterally, as described in the ANNALS by Shroeter and Pazin (April 1970, data presented by a group from the National Communicable Disease Center in Atlanta, Ga.).My unit has seen no cases of gonococcal arthritis...References1. KEISERRUBENWOLINSKY HFE: Clinical forms of gonococcal arthritis. New Eng J Med 279:234-240, 1968 CrossrefMedlineGoogle Scholar2. PARTIANCATHCARTCOHEN JEA: Arthritis associated with gonorrhea. Ann Rheum Dis 27:156, 1968 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSHUA B. GROSSMAN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1971Volume 75, Issue 1Page: 135-136KeywordsArthritisGonorrheaPenicillinSexually transmitted diseases ePublished: 1 December 2008 Issue Published: 1 July 1971 PDF downloadLoading ...
Acute effects of ethanol on cardiac function and intracellular calcium in perfused rat heart
Authors: S. Kojima, S. T Wu, J. Wikman-Coffelt, W. W Parmley
Journal: Cardiovascular Research (1993)

Journal Article Acute effects of ethanol on cardiac function and intracellular calcium in perfused rat heart Get access Shoji Kojima, Shoji Kojima Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA: S Kojima, S T Wu, J Wikman-Coffelt, W W Parmley. Correspondence to Dr Wikman-Coffelt, Room M1186, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0124, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar Shao T Wu, Shao T Wu Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA: S Kojima, S T Wu, J Wikman-Coffelt, W W Parmley. Search for other works by this author on: Oxford Academic PubMed Google Scholar Joan Wikman-Coffelt, Joan Wikman-Coffelt Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA: S Kojima, S T Wu, J Wikman-Coffelt, W W Parmley. Search for other works by this author on: Oxford Academic PubMed Google Scholar William W Parmley William W Parmley Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA: S Kojima, S T Wu, J Wikman-Coffelt, W W Parmley. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 5, May 1993, Pages 811–816, https://doi.org/10.1093/cvr/27.5.811 Published: 01 May 1993 Article history Received: 30 March 1992 Accepted: 28 September 1992 Published: 01 May 1993
Abstract 3329: Investigations into the tumor specific regulation of HER2 by Grp94 in breast cancer
Authors: Pengrong Yan, Hardik Patel, Chenghua Yang, Tony Taldone, Gabriela Chiosis
Journal: Cancer Research (2014)

Abstract Background: Grp94 is the Endoplasmic Reticulum (ER) paralog of the Hsp90 family of chaperones. Overexpression of Grp94 in tumors correlates with advanced stage and poor survival in various cancers and is closely linked to cancer growth and metastasis. Until recently, the major focus of cancer related studies on Grp94 was on the involvement of this protein in the secretion of IGF-II and the regulation of Toll-Like Receptors (TLRs) and integrins. Objective/Hypothesis: Our group combined compound library screening with computational tools to develop potent and selective inhibitors of Grp94 and of Hsp90, the cytosolic HSP90 paralog. We hypothesize that these small molecules are important pharmacologic tools to investigate, in a tumor-by-tumor manner, Grp94 and Hsp90 associated oncogenic mechanisms. Approach/Results: Using the Hsp90 paralog specific inhibitors we produce preliminary evidence for an unanticipated role for Grp94 in maintaining the architecture of high density HER2 formations at the plasma membrane, particularly in cancer cells where HER2 is required to channel an amplified signaling through the receptor. Our data indicate that under conditions in which stress is imposed on the cell by proteome alterations (i.e. HER2 overexpression), the chaperoning function of Grp94 is vital for proper HER2 functioning. In these cells Grp94 translocates to the plasma membrane where it functions to maintain an active conformation of HER2 and to stabilize downstream signaling through the receptor. Our data show that inhibition of Grp94 in these cells is sufficient to destabilize membrane HER2, inhibit its signaling properties and target HER2 towards a degradative pathway. These effects are associated with cancer cell viability loss and induction of apoptosis. Significance: These findings reveal a novel mechanism of HER2-regulation at the plasma membrane, where Grp94 is implicated in HER2 regulation at this location in the specific case of HER2 positive tumors. They also provide a strong rationale for the use of these inhibitors in the investigation of Grp94 associated oncogenic mechanisms. Further, this study proposes the development of Grp94-based cancer therapeutics for HER2 overexpressing breast cancer. Citation Format: Pengrong Yan, Hardik Patel, Chenghua Yang, Tony Taldone, Gabriela Chiosis. Investigations into the tumor specific regulation of HER2 by Grp94 in breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3329. doi:10.1158/1538-7445.AM2014-3329
European paediatric clinical trials miss priority needs, warns review
Authors: M. Day
Journal: BMJ (2008)

Key studies that are needed to assess the efficacy and safety of medicines in children are not being done, according to a major review of clinical trials in Europe which shows that few studies are being carried out in priority areas.

A research group at the Mario Negri Pharmacological Research Institute in Milan, Italy, reviewed all paediatric clinical trials carried out from 2004 to 2007, after identifying them from a literature search.

The 379 paediatric trials being carried out in the European Union during this period dealt with only four of the 25 priority conditions identified by the European Medicines Agency …
Nursing Home Quality
Authors: Mike Mitka
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal