tbuckley/cabot-search huggingface dataset:
Chronic Infection and Coronary Risk
Authors: Michael Mogadam
Journal: Annals of Internal Medicine (2000)

Letters16 May 2000Chronic Infection and Coronary RiskMichael Mogadam, MDMichael Mogadam, MDGastroenterology & Lipid Disorders; Alexandria, VA 22304 (Mogadam)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-10-200005160-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Ridker and colleagues (1) conclude that “little evidence was found that previous infection, as measured by IgG antibody titers to C. pneumoniae … , is associated with subsequent risk for cardiovascular disease.” This conclusion was based on a 3-year follow-up of 17 women with antibody titers of 1:64 or greater, only 5 of whom had titers of 1:128 or greater (the authors' Table 1). The adjusted rate ratio for cardiovascular events (acute myocardial infarction, stroke, or coronary revascularization) in these 17 women was similar to that in antibody-negative controls (titers ≥ 64 are considered positive according to ...Reference1. Ridker PM, Hennekens CH, Buring JE, Kundsin R, Shih J. Baseline IgG antibody titers to Chlamydia pneumoniae, Helicobacter pylori, herpes simplex virus, and cytomegalovirus and the risk for cardiovascular disease in women. Ann Intern Med. 1999;131:573-7. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Gastroenterology & Lipid Disorders; Alexandria, VA 22304 (Mogadam) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBaseline IgG Antibody Titers to Chlamydia pneumoniae, Helicobacter pylori, Herpes Simplex Virus, and Cytomegalovirus and the Risk for Cardiovascular Disease in Women Paul M. Ridker , Charles H. Hennekens , Julie E. Buring , Ruth Kundsin , and Jessie Shih Metrics 16 May 2000Volume 132, Issue 10Page: 842KeywordsCOVID-19Cardiovascular disease riskCardiovascular diseasesCoronary arteriesInfectious diseasesMedical risk factorsMyocardial infarctionPelvic inflammatory diseasePneumoniaStable coronary artery disease Issue Published: 16 May 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ranibizumab in Myopic Choroidal Neovascularization: The 12-Month Results from the REPAIR Study
Authors: Adnan Tufail, Nirodhini Narendran, Praveen J. Patel, Sobha Sivaprasad, Winfried Amoaku, Andrew C. Browning, Olayinka Osoba, Richard Gale, Sheena George, Andrew J. Lotery, Mohammed Majid, Martin McKibbin, Geeta Menon, Christopher Andrews, Christopher Brittain, Aaron Osborne, Yit Yang
Journal: Ophthalmology (2013)
100,000 and counting
Authors: M. S. Litwin
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mental capacity to make decisions on treatment in people admitted to psychiatric hospitals: cross sectional study
Authors: G. S Owen, G. Richardson, A. S David, G. Szmukler, P. Hayward, M. Hotopf
Journal: BMJ (2008)

<b>Objective</b> To estimate the prevalence of mental capacity to make decisions on treatment in people from different diagnostic and legal groups admitted to psychiatric hospital. <b>Design</b> Cross sectional study. <b>Setting</b> General adult acute psychiatric inpatient units. <b>Participants</b> 350 consecutive people admitted to psychiatric wards from the community over 16 months. <b>Main outcome measure</b> Mental capacity assessed by clinical interview and the MacArthur competence assessment tool for treatment. <b>Results</b> Estimates of mental capacity were obtained on 97% (n=338) of the 350 people admitted. Of those an estimated 60% (95% confidence interval 55% to 65%) lacked mental capacity to make decisions on treatment. This proportion varied according to diagnosis, ranging from 97% (n=36) in people with mania to 4% (n=24) in people with personality disorder. Mental incapacity was common in patients admitted informally to the psychiatric wards (n=188; 39%, 32% to 46%). Incapacity and detention are closely associated under non-capacity based mental health law. <b>Conclusions</b> Mental incapacity to make decisions on treatment is common in people admitted to psychiatric wards from the community but cannot be presumed. It is usual in those detained under the Mental Health Act and common in those admitted voluntarily.
Clinical aspects of polycystic disease of the kidneys.
Authors: H Mitcheson, G Williams, J E Castro
Journal: BMJ (1977)

Seventy-eight patients were treated for polycystic disease of the kidneys. An analysis of the interval between the onset of symptoms and end-stage renal failure made it possible to give and accurate prognosis in individual cases. Pregnancy and urinary infection did not appear to accelerate deterioration of renal function, but Rovsing' operation precipitated renal failure in some cases. Forty-two patients needed replacement treatment for end-stage renal failure, and 24 patients received 29 renal allografts. Transplant function at all times was better than a matched group of 70 patients indications for removal of polycystic kidneys in graft recipients were persistnet or recurrent infection, erythraemia that failed to respond to conservative treatment, and to make room for the transplant.
The Heart and Circulation in the Newborn and Infant
Authors: Donald C. Fyler
Journal: JAMA (1967)

The purpose of this symposium was to discuss selected topics concerning the normal and abnormal circulation of the fetus and infant. A distinguished panel of 35 experts presented papers which were organized into the following sections: (1) Physiology of the Fetal Circulation, (2) Physiologic Adjustments in the Newborn, (3) Hemodynamic and Biochemical Abnormalities in the Newborn with Heart Disease, (4) The Pathology of the Heart in the Transition Period, (5) Electrocardiography, (6) Surgery of the Heart and Great Vessels in the First Six Months of Life. Selected guests took part in the discussions of each paper.  The book provides the edited presentations of each expert and limited discussion. Pertinent tabular and photographic figures are included, but unfortunately, not the data of the discussors' slides. Ordinarily this would not be a significant oversight, but one of the most interesting pieces of factual data presented came out in the discussion of the
WHO puts abortifacients on its essential drug list
Authors: Liza Gibson
Journal: BMJ (2005)

The World Health Organization has put two abortifacient drugs on its list of essential medicines to offer an alternative to surgical methods that are often used in developing countries.

The WHO holds a list of what it considers essential medicines for developing countries—in other words, medicines that “satisfy the priority healthcare needs of the population” and that are selected on the basis of their efficacy, safety, and cost effectiveness. It will be adding to this list the combination under “close medical supervision” of mifepristone followed, some 36 to 48 hours later, by misoprostol, to induce abortion within nine weeks of pregnancy.

The approval will be of particular benefit to developing …
Confusion expertly managed
Authors: P. Finucane
Journal: BMJ (2003)

In people with dementia, an exacerbation of confusion at day's end is often referred to as “sundowning.” We encountered this phenomenon on a recent flight between Croatia and London, when a dramatic Alpine sunset was overshadowed by an even greater drama on board. An elderly passenger became increasingly agitated, and neither his wife nor other passengers and cabin crew could appease him. His interest in the nearby emergency exit and a metal object protruding from his clenched fist worried us all.

Happily, disaster was averted. The …
The Clinical Effectiveness of Pneumococcal Vaccine in the Elderly
Authors: RICHARD V. SIMS
Journal: Annals of Internal Medicine (1988)

The effectiveness of pneumococcal vaccine in the immunocompetent elderly remains controversial. We report the results of a multicenter, case-control study of 244 controls and 122 patients, aged 55 years and older, hospitalized during a 5-year period with pneumococcal bacteremia, meningitis, or other bacteriologically confirmed pneumococcal infection. Two controls per patient were matched on the basis of admission date, hospital records, and underlying diseases. All subjects were selected without knowledge of immunization status with pneumococcal vaccine, and were excluded if there was evidence for immunosuppression due to disease or iatrogenic causes. The clinical effectiveness of the vaccine was calculated to be 70% (95% confidence intervals [CI], 37% to 86%) in this population, based on a Mantel-Haenszel point estimate of the odds ratio of 0.30 (95% CI, 0.14% to 0.63%; P less than 0.005). The clinical effectiveness of pneumococcal vaccine in preventing pneumococcal infection in the immunocompetent elderly approximates the vaccine's effectiveness in the general immunocompetent population.
CLINICAL PRESENTATION OF IN-STENT RESTENOSIS AND ANGIOGRAPHIC CONFIRMED STENT THROMBOSIS IN PATIENTS TREATED WITH BARE METAL OR DRUG-ELUTING STENTS. FROM WESTERN DENMARK HEART REGISTRY
Authors: Per Thayssen, Lisette Okkels Jensen, Anne Kaltoft, Hans Henrik Tilsted, Michael Maeng, Evald Hoej Christiansen, Knud N. Hansen, Jan Ravkilde, Jan Ravkilde, Lars Krusell, Jens F. Lassen, Leif Thuesen
Journal: Journal of the American College of Cardiology (2010)
Work of staff grade doctors does not get proper recognition
Authors: Oona Mashta
Journal: BMJ (2006)

Some hospital doctors are not getting the recognition they deserve, despite carrying out more than one in 10 of the United Kingdom's operations every year, a BMA report says.

The BMA wants to highlight the contribution made by staff grade and associate specialist (SAS) doctors to the care of patients and the running of the NHS.

The BMA's report found that in the UK in 2002 there were 7545 weekday daytime operations—12% of the total number carried out—in which the senior surgeon was an SAS doctor.

The report said that this group of doctors accounts for almost half (49%) of accident and emergency doctors in England, …
Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential
Authors: L M Neri, A Cani, A M Martelli, C Simioni, C Junghanss, G Tabellini, F Ricci, P L Tazzari, P Pagliaro, J A McCubrey, S Capitani
Journal: Leukemia (2013)
Metastasis of Cancer to Cancer
Authors: R. A. Pribek
Journal: JAMA (1962)

MULTIPLE primary malignant neoplasms are now regarded as a common occurrence and not a medical curiosity. Despite the relative frequency of multiple malignant tumors, instances of one cancer metastasizing to another are most uncommon. The case described in this report is an example of this rare and curious association. Report of a Case A 68-year-old white male entered St. Francis Hospital, La Crosse, Wis., for the first time on June 10, 1958, because of pain in the middorsal spine of 2 weeks' duration. The pain was described as sharp, severe, and continuous, with radiation to the right lower chest anteriorly. System review was otherwise negative. Past medical history was not remarkable. His mother died of metastatic carcinoma of the thyroid at age 65. Physical examination revealed a well-developed, moderately obese man with normal vital signs. Examination of the head and neck disclosed a single, 2-cm. firm node in the left
Naloxone for Diagnosis in Methadone Programs
Authors: Paul H. Blachly
Journal: JAMA (1973)

Naloxone hydrochloride is safe, effective, rapid, and inexpensive for the diagnosis of physical dependence on opiates. It may be used in an outpatient setting with a minimum of personnel. Unlike urinalysis, it will distinguish a person who is physically dependent from one who is an occasional user, and in 10 to 35 minutes. A significant hazard exists in creating addicts to methadone hydrochloride, since a third of those applying to a methadone clinic without prior documentation of withdrawal in an institution showed no evidence of physical dependence.
Effects of Prolonged Storage of Whole Plasma or Isolated Plasma DNA on the Results of Circulating DNA Quantification Assays
Authors: Gabriella Sozzi, Luca Roz, Davide Conte, Luigi Mariani, Francesca Andriani, Paolo Verderio, Ugo Pastorino
Journal: JNCI Journal of the National Cancer Institute (2005)

Analysis of molecular markers in biological fluids has been proposed as a tool for early detection and monitoring of cancer. Circulating plasma DNA concentrations have been found to be higher in cancer patients than in cancer-free control subjects, but little is known about the effect of specimen storage on plasma DNA concentrations. Here we investigated the impact of long-term storage of both plasma samples and purified plasma DNA on the reproducibility of plasma DNA quantification as determined using real-time polymerase chain reaction analysis. The analysis was performed on samples from a subset of 34 lung cancer patients and 28 matched control subjects selected from 200 subjects in our previously published case-control study and from 117 cancer-free smokers enrolled in a lung cancer screening program. Two samples of plasma and isolated DNA were assessed for each patient, with a median of 41 months between the first and second assessments for participants in the case-control study and 9 months for participants in the screening study. DNA levels declined substantially between the two assessments at an average rate of approximately 30% per year. These data provide valuable information for the rational planning of retrospective studies of banked series of biological samples, particularly if collected over a long period of time, as can occur in large clinical trials.
Simultaneous Multisite Mapping of the Right and the Left Atrial Septum in the Canine Intact Beating Heart
Authors: Huabin Sun, Emre O. Velipasaoglu, David E. Wu, Helen A. Kopelen, William A. Zoghbi, William H. Spencer, Dirar S. Khoury
Journal: Circulation (1999)

Background —The spread of activation between the right atrium (RA) and left atrium (LA), particularly along the right and left aspects of the interatrial septum, is not clear. Methods and Results —Basket-shaped catheters carrying 64 electrodes were deployed into both the RA and LA of 10 dogs. Position and orientation of the baskets were determined by fluoroscopy and echocardiography. Basket unipolar electrograms were simultaneously recorded in each dog during sinus rhythm, right ventricular pacing, and pacing of the right septum through the basket in the superior and inferior regions. Isochrone maps depicting all aspects of the atria, including the septum, were compared. During sinus rhythm and superior right septal pacing, wave fronts propagated predominantly from superior to inferior regions on both the right and left septum. However, activation of the left septum was delayed compared with the right septum. During right ventricular pacing and inferior right septal pacing, activation of the septum was discordant; 1 wave front propagated rapidly on the right septum from inferior to superior regions, whereas 2 opposing wave fronts originated on the left septum in both the superior and inferior regions. The left septum was activated predominantly by the superior wave front. Activation of the left septum was completed in a significantly shorter time during pacing of the right septum in the inferior region compared with the superior region. Conclusions —In dogs, activation of the right and left aspects of the interatrial septum is discordant. Electrical connections are present between the RA and LA in regions superior as well as inferior to the septum.
Authorship and Other Credits
Authors: N FOTION
Journal: Annals of Internal Medicine (1984)

Coauthorship of articles and case reports in medical journals is causing serious academic problems. Many persons who are listed as authors do not contribute as authors but rather as clinical investigators, statisticians, or program directors. In effect, a dishonest practice has developed that allows contributors to medical research to receive the honorific title of author when this title is not deserved. To help stop this practice, we urge a shift from the concept of authorship to a more general concept of receiving credit. Persons who contribute to articles as authors should be so credited, but those who contribute as clinical investigators, for example, should receive credit as clinical investigators, not authors. Instead, clinical investigators should receive credit by having their names listed alongside the authors' and by being permitted to list their nonauthorial contributions in their curricula vitae.
Non-Osseous Bone Scan Abnormalities in Multiple Myeloma Associated with Hypercalcemia
Authors: BARRY A. EAGEL, STEVEN A. STIER, CHRISTOPHER WAKEM
Journal: Clinical Nuclear Medicine (1988)

Uptake of Tc-99m MDP by extraskeletal tissues is a rare, serendipitous finding during bone scanning studies. It can be clinically correlated with the presence of hypercalcemia in association with renal failure, as may occur in multiple myeloma. While the precise mechanism of non-osseous uptake of MDP is not certain, it may represent metastatic calcification based upon histological examination. A critical calcium-phosphate ion product appears to be requisite for deposition within soft tissues, and all cases in the literature for which data were available exceeded this ion product value. While MDP bone scanning is not generally useful in the diagnosis or staging of multiple myeloma, these findings may indicate secondary effects of the disease. The authors report the first case of liver, spleen, and lung uptake by MDP in a patient with hypercalcemia secondary to multiple myeloma, with a review of the literature.
Potency of brand name and generic levothyroxine
Authors: S. S. Stoffer
Journal: JAMA (1980)

The tablet thyroxine content of a brand name and two generic products were studied. The mean thyroxine content was significantly different in the generic tablets when compared with that in the brand name product. The coefficient of variation of tablet thyroxine was lowest in the brand name, although this product had only 78% of expected potency. When these products were tested in three hypothyroid patients, two serum free thyroxine indexes were well outside the normal range when the most potent generic product was substituted for the brand name drug. Manufacturers should be required to measure the thyroxine content of their tablets. Until such time that levothyroxine products become more uniform, physicians, pharmacists, and legislators should not encourage product switching.
Systematic Reviews: Synthesis of Best Evidence for Health Care Decisions
Authors: David A. Horowitz
Journal: Annals of Internal Medicine (1998)

Medical Writings1 November 1998Systematic Reviews: Synthesis of Best Evidence for Health Care DecisionsDavid A. Horowitz, MDDavid A. Horowitz, MDHospital of the University of Pennsylvania, Philadelphia, PennsylvaniaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-9-199811010-00047 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Systematic Reviews: Synthesis of Best Evidence for Health Care Decisions; Mulrow C, Cook D; eds. 117 pages. Philadelphia: American Coll of Physicians; 1998. $27.00. ISBN 0943126665. Order phone 800-523-1546, ext. 2600.Field of medicine: Any field that involves patient care, clinical decisions, or policymaking.Format: Softcover book.Audience: Health care providers, teachers, researchers, and policymakers. Although some of its content is introductory, the book will be useful to the seasoned clinician and teacher. Those new to clinical decision making and those in training will find it useful as a thorough primer.Purpose: To introduce and expand on the concept of ... Author, Article, and Disclosure InformationAffiliations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1998Volume 129, Issue 9Page: 759-760KeywordsComputersDatabasesDecision makingHealth careHealth care providersInformation technologyPatientsSystematic reviewsTreatment guidelines ePublished: 15 August 2000 Issue Published: 1 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Value of scintigraphy in chronic peritoneal dialysis patients
Authors: Peter H. Juergensen, Hasan Rizvi, Vicente J. Caride, Alan S. Kliger, Fredric O. Finkelstein
Journal: Kidney International (1999)

A variety of factors can adversely impact chronic peritoneal dialysis (CPD) as an effective renal replacement therapy for patients with end-stage renal disease. These factors include peritonitis, poor clearances, loss of ultrafiltration, and a variety of anatomic problems, such as hernias, peritoneal fluid leaks, loculations, and catheter-related problems caused by omental blockage. This study reviews our experience with peritoneal scintigraphy for the evaluation of some of these difficulties.From 1991 to 1996, 50 peritoneal scintigraphy scans were obtained in 48 CPD patients. Indications for scintigraphy were evaluated, and the patients were placed into four groups: group I, abdominal wall swelling; group II, inguinal or genital swelling; group III, pleural fluid; and group IV, poor drainage and/or poor ultrafiltration. A peritoneal scintigraphy protocol was established and the radiotracer isotope that was used was 2.0 mCi of 99mtechnetium sulfur colloid placed in two liters of 2.5% dextrose peritoneal dialysis solution.Ten scans were obtained to study abdominal wall swelling, with seven scans demonstrating leaks; six of these episodes improved with low-volume exchanges. Twenty scans were obtained to evaluate inguinal or genital swelling, and 10 of these had scintigraphic evidence for an inguinal hernia leak (9 of these were surgically corrected). One of four scans obtained to evaluate a pleural fluid collection demonstrated a peritoneal-pleural leak that corrected with a temporary discontinuation of CPD. Sixteen scans were obtained to assess poor drainage and/or ultrafiltration. Five of these scans demonstrated peritoneal location, and all of these patients required transfer to hemodialysis. The other 11 scans were normal; four patients underwent omentectomies, allowing three patients to continue with CPD.Peritoneal scintigraphy is useful in the evaluation and assessment of CPD patients who develop anatomical problems (such as anterior abdominal, pleural-peritoneal, inguinal, and genital leaks) and problems with ultrafiltration and/or drainage.
INCREASED BRAIN DOPAMINE AND REDUCED GLUTAMIC ACID DECARBOXYLASE AND CHOLINE ACETYL TRANSFERASE ACTIVITY IN SCHIZOPHRENIA AND RELATED PSYCHOSES
Authors: EdwardD. Bird, Joanna Barnes, LeslieL. Iversen, ErnestG. Spokes, AngusV.P. Mackay, Michael Shepherd
Journal: The Lancet (1977)