tbuckley/cabot-search huggingface dataset:
Pregnancy and obstetrical outcomes in pseudoxanthoma elasticum
Authors: L. Bercovitch, T. Leroux, S. Terry, M.A. Weinstock
Journal: British Journal of Dermatology (2004)

Background Pseudoxanthoma elasticum (PXE) is a genetic multisystem disorder characterized by calcified dystrophic elastic fibres in skin, retina and arteries. Much of the earlier literature on pregnancy in PXE contained reports of severe complications, leading some healthcare providers to advise women with PXE against becoming pregnant and some women with PXE to avoid pregnancy. Objectives To evaluate the obstetrical outcomes and the incidence of pregnancy complications in women with PXE and to determine if pregnancy is associated with an adverse effect on the course of the disease. Methods Women with PXE (n = 407) answered detailed questionnaires regarding reproductive history and pregnancy as well as the course of their disease. The frequency of reported pregnancy outcomes and complications was determined. Severity indices for the major clinical manifestations of PXE were developed and correlated with gravidity of affected women aged 40 years or over. Results Among the 306 respondents with PXE who had ever been pregnant, there were 795 pregnancies. Of these, 83% ended in live births and 1% in stillbirth. The median birth weight was within the normal range and the incidence of low birth weight for gestation was low. Hypertension occurred in 10% of pregnancies, gastric bleeding and retinal complications in < 1%, and 12% of pregnancies were associated with worsening of skin manifestations. There was no effect of gravidity and clinical severity on cutaneous (P = 0·07), ocular (P = 0·59) or cardiac (P = 0·42) manifestations of PXE in women aged 40+ years, nor did ever having been pregnant adversely affect these clinical severity indices. Of the 101 women who had never been pregnant, 17% made the decision because they were advised against becoming pregnant by a healthcare professional and 11% did not become pregnant because they feared an adverse outcome either in their pregnancy or disease. Conclusions PXE is not associated with markedly increased fetal loss or adverse reproductive outcomes. The incidence of gastric bleeding, although probably higher than in the unaffected population, is much lower than previously reported, and retinal complications are uncommon. Although a few pregnancies were associated with worsening of skin manifestations, there was no correlation of either gravidity or ever having been pregnant with ultimate severity of skin, ocular or cardiovascular manifestations. There is no basis for advising women with PXE to avoid becoming pregnant, and most pregnancies in PXE are uncomplicated.
Cataracts and Inhaled Corticosteroids
Authors: Leo T. Chylack
Journal: New England Journal of Medicine (1997)

In this issue of the Journal, Cumming et al. report an association between the use of inhaled corticosteroids and the development of posterior subcapsular and nuclear cataracts.1 Although this association was not unexpected — the use of systemic corticosteroids is a risk factor for cataracts — published surveys of smaller groups have not demonstrated a link between inhaled corticosteroids and cataracts. Barenholtz2 recently concluded that corticosteroids administered by nasal inhalation have no effect on the risk of posterior subcapsular cataracts. Abuekteish et al.3 concluded that screening for cataract was unnecessary in children receiving inhaled corticosteroids alone. Using modern ophthalmologic techniques, . . .
1024-50 Recanalized chronic total occlusions covered by sirolimus-eluting stents
Authors: JoséSuárez de Lezo, José Segura, Alfonso Medina, Manuel Pan, Antonio Delgado, Miguel Romero, Juan Herrador, Isabel Ureña, Djordje Pavlovic, Federico Segura, Francisco Melián, Luis Burgos
Journal: Journal of the American College of Cardiology (2004)
Overweening on weaning
Authors: Des Spence
Journal: BMJ (2011)

When I was 10 my mum had twin boys. I spent much of my childhood smelling of baby sick, feeding, winding, and changing my brothers’ nappies. I have no idea when they were weaned—Mum used her judgment. We scooped mashed-up food into the yelling mouths; they like buttered potatoes and gravy best. We were skint, so there were no processed baby foods. My brothers have spent the rest of their lives borrowing money and drinking my beer.

I was used to having babies and children around. So I was bemused when my pregnant …
Phleborheography for Thrombosis
Authors: JOHN J. CRANLEY
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 December 1978Phleborheography for ThrombosisJOHN J. CRANLEY, M.D.JOHN J. CRANLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-6-1006_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Among their results in diagnosis of deep venous thrombosis by the phleborheograph in 75 patients also studied by venography, Bynum and associates (Ann Intern Med89:162-166, 1978) found a false-negative rate of 31%. This should be examined, since in our series of 228 patients with deep venous thrombosis proven radiographically the gross false-negative rate was 8.2%. Five of our 19 errors were technical or interpretational, and 13 (5.7%) were inherent in the method. All but one clot missed by phleborheography were below the popliteal vein. In their series, six of 11 errors were thrombi in the intramuscular...References1. KAKKARNICOLAIDESRENNEYFRIENDCLARKE VAJJM: Natural history of postoperative deep venous thrombosis. Lancet 2:230-232, 1969 CrossrefMedlineGoogle Scholar2. CRANLEY J: Vascular Surgery. Volume II. Peripheral Venous Diseases. Hagerstown, Maryland; Harper & Row, 1975, p. 89 Google Scholar1. BYNUMWILSONCROTTYCURRYSMITSON LJCTH: Noninvasive diagnosis of deep venous thrombosis by phleborheography. Ann Intern Med 89:162-166, 1978 LinkGoogle Scholar2. KAKKARNICOLAIDESRENNEYFRIENDCLARKE VAJJM: Natural history of postoperative deep venous thrombosis. Lancet 2:230-232, 1969 CrossrefMedlineGoogle Scholar3. ADARSALZMAN RE: Treatment of thrombosis of the lower extremities. N Engl J Med 292:348-350, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Good Samaritan Hospital Cincinnati, OH 45220 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThromboembolic Disease in the Patient Undergoing Urologic Surgery 1 December 1978Volume 89, Issue 6Page: 1006-1007KeywordsDeep vein thrombosisVeins Issue Published: 1 December 1978 PDF DownloadLoading ...
Complete heart block caused by primary Sjogren's syndrome and hypopituitarism
Authors: D. C BAUMGART, H. GERL, T. DORNER
Journal: Annals of the Rheumatic Diseases (1998)

Sjogren’s syndrome is a systemic autoimmune disease characterised by lymphocytic infiltration of exocrine glands accompanied by a variety of extraglandular manifestations.1 Endocrinological manifestations, however, are infrequently encountered with the exception of autoimmune thyroiditis.2 3 

Here we report a case of combined Sjogren’s syndrome and hypopituitarism where the patient presented with complete heart block. To date the only two cases reported were published in Japanese.4 5 

A 76 year old woman was brought to the emergency room for syncope. She was diagnosed with bradycardia resulting from atrioventricular block with a ventricular rhythm of 30 bpm and a VVI pacemaker was placed to control the life threatening bradycardia. Her complaints were chronic fatigue, cold intolerance, decreased appetite, xerostomia, and dry eyes over the past five …
241 POSITIVE IMPACT ON SURVIVAL OF MELD PRIORITIZATION FOR PATIENTS WITH CIRRHOSIS AND SMALL UNRESECTABLE HEPATOCELLULAR CARCINOMA COMPARED TO LIVING DONOR LIVER TRANSPLANTATION
Authors: A. Villamil, O. Galdame, J.C. Bandi, P. Casciato, V. Ardiles, E. de Santibanes, A. Gadano
Journal: Journal of Hepatology (2008)
A BRIEF CONTRIBUTION TO THE BIOLOGY OF THE MALARIAL PARASITE.
Authors: R. S. WOODSON
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastroenterology and Hepatology
Authors: Arvydas Vanagunas, J. Donald Ostrow
Journal: JAMA (1986)

Although endoscopy is an established and useful diagnostic tool, its emergency use in acute gastrointestinal tract bleeding has not reduced mortality.<sup>1</sup>However, high-risk groups whose management and ultimate outcome might be influenced favorably by early endoscopy have been identified: patients with visible vessels or fresh blood in ulcer craters (who rebleed at a rate of 58% )<sup>2</sup>and patients with a history of alcohol abuse or those who rebleed in the hospital after stabilization.<sup>3</sup>Emergency colonoscopy, performed after a large-volume purge in patients with acute passage of bloody or maroon stools per rectum, has been very useful. The source of bleeding was established in 88% of these difficult patients, 17% of whom had an upper gastrointestinal tract source.<sup>4</sup> Advances in therapeutic endoscopy continue. Although there is increasing use of thermal therapy with bipolar electrodes, heater probes, and direct application of laser in gastrointestinal tract bleeding, a consensus
Uriniferous Perirenal Pseudocyst in a Neonate with Primary Obstructive Megaureter
Authors: NALINI BIDANI, THOMAS E. HERMAN, MARY ANN RADKOWSKI, ANN M. KIERAN
Journal: Clinical Nuclear Medicine (1982)

The case of a newborn infant with a high-grade ureterovesical junction obstruction—a primary obstructive megaureter—who presented with a perirenal pseudocyst (urinoma) is discussed. Radionuclide studies allowed recognition of this collection and led to the discovery of the ureteral obstruction. The rarity of urinomas in neonates and the scintigraphic appearance of urinomas are emphasized.
Hyperglycemic and Hypoglycemic Crises
Authors: Stephen R. Newmark
Journal: JAMA (1975)

METABOLIC abnormalities involving glucose metabolism are the most common endocrine dysfunctions seen in internal medicine. We will cover the three most important abnormalities of glucose metabolism that constitute medical emergencies. As a general rule, it is stressed that in all comatose patients where the diagnosis is not known, the blood glucose level should be measured.  Diabetic Ketoacidosis  Clinical Presentation.—  Diabetic ketoacidosis is a state of severe insulin deficiency characterized by hyperglycemia, systemic acidosis, and hyperketonemia. The diabetic patient is unable to incorporate glucose into metabolic pathways because of insulin deficiency. There is also an increased mobilization of fat and protein stores secondary to insulin deficiency. The products of these stores subsequently accumulate in the form of the ketoacids. The resulting systemic acidosis and osmotic diuresis cause severe derangements in electrolyte and acid-base composition as the obligatory renal loss of glucose and ketoacids results in increased cation excretion. The fluid loss
PRENEURASTHENIC AND PREINSANE CONDITIONS
Authors: ROSS MOORE
Journal: JAMA (1913)

It is with a good deal of hesitation that I again present a subject on which I wrote two years ago. The longer I practice among the nervous and the insane, the stronger is the desire to have a hand in preventing their troubles rather than in curing them. The particular reason for this short paper is to bring out a full discussion of the question of prevention.  For a number of years when examining children I have tried to make up my mind as to what kind of adults they were to become. Results have been most disappointing in the main.  The disappointing thing was that I was not succeeding in finding, among children examined who were evidently not up to an average mental and nerve constitution, any classes or types of temperament to indicate their future neurologic or psychiatric dangers. To put it another way, after I had
Sir Thomas Browne (1605-1682)
Authors: John H. Dirckx
Journal: JAMA (1982)

THIS week marks the 300th anniversary of the death of Sir Thomas Browne, a physician chiefly remembered for his contribution to English letters, an experimenter and reasoner who helped to shape the course of early modern science, and a philosopher and moralist who would have been a credit to any profession. Thomas Browne was born on Oct 19, 1605, the son of a well-to-do London tradesman, who died when Thomas was 8 years old. After completing his preliminary schooling at Winchester College, Browne entered Pembroke College, Oxford, in 1623 and remained there until 1629, when he received the degree of master of arts. Inspired by Dr Thomas Clayton, professor of anatomy and medicine at Pembroke, Browne chose a medical career, and, since his means permitted it, he attended the best continental schools. He spent some time at Montpellier, France, and Padua, Italy, and finished his training at Leyden, the Netherlands,
Screening and management of familial adenomatous polyposis.
Authors: A D Spigelman, K P Nugent, R K Phillips
Journal: Gut (1993)

stones or more than one stone.The paper fails to make any comment on symptom relief, however, and the surprising result of our lithotripsy trial' was that the symptoms were relieved, just as much as after cholecystectomy, within the first month of treatment, well before any stones had disappeared; and the pain relief for the whole year and the relief of many other symptoms did not depend on stone clearance: so we have to distinguish between success in terms of stone clearance and success in terms of symptom relief.Lithotripsy, for whatever reason seems a very cost effective way of doing the second, at least in the short term.We are at present following up our patients for longer periods to see if this symptom improvement is maintained.
Intravenous Diazepam Administration
Authors: Martin F. Keller
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The finding, that intravenously administered diazepam causes phlebitis is well documented by Langdon et al (223:184, 1972) and confirmed by the observations of Wehlage (224:128, 1973). We also found the high chance for a thrombophlebitis after intravenous diazepam administration. What I miss in the above mentioned communications is the discussion of the cause of this adverse drug reaction; I offer the following explanation. Another drug, that when intravenously administered often leads to thrombophlebitis especially after multiple applications, is diphenylhydantoin (Epanutin). The solvent of both diazepam and diphenylhydantoin is identical and consists of propylenglycolum 40%. This chemical is necessary for watersolubility and unfortunately irritates the endothelium of veins. The choice of big veins and slow injection reduce the risk for thrombophlebitis.
Interactions of a very long chain fatty acid with model membranes and serum albumin. Implications for the pathogenesis of adrenoleukodystrophy.
Authors: J K Ho, H Moser, Y Kishimoto, J A Hamilton
Journal: Journal of Clinical Investigation (1995)

Adrenoleukodystrophy (ALD) is an inherited disorder of fatty acid metabolism marked by accumulation of very long chain saturated fatty acids (VLCFA), especially the 26-carbon acid, hexacosanoic acid (HA), in membranes and tissues. We have studied interactions of 13C-enriched HA with model membranes (phospholipid bilayer vesicles) and bovine serum albumin (BSA) by 13C NMR spectroscopy to compare properties of HA with those of typical dietary fatty acids. In phospholipid bilayers the carboxyl group of HA is localized in the aqueous interface, with an apparent pKa (7.4) similar to other fatty acids; the acyl chain must then penetrate very deeply into the membrane. Desorption of HA from vesicles (t1+2 = 3 h) is orders of magnitude slower than shorter chain fatty acids. In mixtures of vesicles and BSA, HA partitions much more favorably to phospholipid bilayers than typical fatty acids. BSA binds a maximum of only 1 mole of HA at one binding site. Calorimetric experiments show strong perturbations of acyl chains of phospholipids by HA. We predict that disruptive effects of VLCFA on cell membrane structure and function may explain the neurological manifestations of ALD patients. These effects will be further amplified by slow desorption of VLCFA from membranes and by the ineffective binding to serum albumin.
A Word From Our Moderator
Authors: Japp Deinum, Gert Jan van der Wilt
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bush criticised for not giving AIDS money to Global Fund
Authors: S. Macdonald
Journal: BMJ (2003)

The Global Fund to fight AIDS, tuberculosis, and malaria needs an extra $6.3bn (£3.8bn; €5.8bn) in contributions over the next two years if it is to approve a third round of grants in October.

The fund made the announcement only days after President George Bush said in his state of the union address that he would pledge $15bn to combat AIDS. Only $1bn of this will be given to the Global Fund.

Welcoming President Bush's pledge, director general of the World Health Organization, Dr Gro Harlem Brundtland, emphasised the need for an annual $10bn to stem …
A new tongue advancement technique for sleep-disordered breathing: side effects and efficacy.
Authors: B Schönhofer, R A Stoohs, H Rager, M Wenzel, G Wenzel, D Köhler
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

We examined the efficacy and the acceptance of an oral device (SnorEx) causing a forward displacement of the tongue for the treatment of sleep-disordered breathing (SDB). Twenty-three consecutive subjects with SDB were investigated. Noncompliance (NC) of use of the oral appliance was observed in 74% (17 of 23) of the subjects. NC patients were characterized by unacceptable local side effects of the prosthesis, lacking improvement of indicators of daytime well-being, and a missing reduction of the respiratory disturbance index (RDI). The device was tolerated without side effects in 26% (6 of 23) of the subjects. In these compliant (C) subjects the RDI, EDS, and snoring improved significantly (p < 0.05) compared with baseline values. After 6 mo using the device, five of the six C patients were still using it. We conclude that the high rate of noncompliance and the low efficacy of the SnorEx prosthesis preclude large-scale use of this treatment modality in patients with SDB and snoring since the local side effects are the principal cause of NC. No useful predictive parameter of treatment compliance or treatment success was found. Thus, this dental appliance should be prescribed only for selected patients failing other treatment modalities seen by an experienced sleep-disorders specialist.
Role of nitric oxide in endotoxin-induced metabolic and vascular dysregulation of the canine diaphragm.
Authors: S N Hussain
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

We assessed the role of nitric oxide (NO) in the regulation of diaphragmatic O2 uptake (Vo2di) and phrenic vascular resistance during endotoxemia in anesthetized, mechanically ventilated dogs. Left diaphragmatic vasculature was isolated and briefly pump perfused with arterial blood at a normal flow rate, at a high rate (50% higher than normal), and at low rat (60 to 70% lower than normal). At each rate, Vo2di and phrenic perfusion pressure (Pphr) were measured. Escherichia coli endotoxin (100 mg) was infused intravenously over 90 min in several groups of animals, whereas normal saline was infused into the other. Endotoxin infusion increased Vo2di and reduced Pphr at a given flow rate. These parameters remained unchanged in the saline-infused animals. Infusion of NG-nitro-L-arginine methyl ester (LNAME 6 x 10(-4) M) into the phrenic artery of the endotoxin group reversed the decline in Pphr with no effect on Vo2di. LNAME infusion in the saline group increased Pphr at normal and high flow rates only. Single intravenous injections of LNAME increased arterial pressure and reduced cardiac output in endotoxemic animals, whereas only an increase in arterial pressure was observed in saline-infused animals. Serum arterial and phrenic venous NO concentrations measured in separate groups of animals increased significantly after endotoxin infusion, whereas saline infusion had no effect on these parameters. These results indicate that enhanced NO release plays a significant role in endotoxin-induced phrenic and systemic vasodilation. However, the increase in Vo2di in the endotoxin group does not seem to be mediated by NO release.