The Familial Occurrence of Chronic Obstructive Pulmonary Disease
Authors: ROGER K. LARSON
Journal: Annals of Internal Medicine (1965)

Article1 December 1965The Familial Occurrence of Chronic Obstructive Pulmonary DiseaseROGER K. LARSON, M.D., F.A.C.P., MARTIN L. BARMAN, M.D.ROGER K. LARSON, M.D., F.A.C.P.Search for more papers by this author, MARTIN L. BARMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-1001 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe etiology of chronic obstructive pulmonary emphysema remains obscure despite intensive efforts to elucidate its pathogenesis (1). Only the roles of tobacco smoking and chronic bronchitis seem to be generally accepted as significant factors (2-6). It is well recognized, however, that chronic obstructive pulmonary emphysema is not confined to smokers or persons with a clear-cut antecedent history of chronic bronchitis. Furthermore, in the author's experience considerable variability is encountered in the toll exerted by cigarette smoking on pulmonary function. Many heavy smokers of long duration have normal or only mildly abnormal pulmonary function while some severely disabled victims of chronic...References1. EBERTPIERCE RVJA: Pathogenesis of pulmonary emphysema. Arch. Intern. Med. (Chicago) 111: 34, 1963. CrossrefGoogle Scholar2. LOWELLFRANKLINMICHELSONSCHILLAR FCWALJW: Chronic obstructive pulmonary emphysema: a disease of smokers. Ann. Intern. Med. 45: 268, 1956. LinkGoogle Scholar3. FRANKLINLOWELL WFC: Unrecognized airway obstruction associated with smoking: a probable forerunner of obstructive pulmonary emphysema. Ann. Intern. Med. 54: 379, 1961. LinkGoogle Scholar4. FLICKPATON ALRR: Obstructive emphysema in cigarette smokers. Arch. Intern. Med. (Chicago) 104: 518, 1959. CrossrefMedlineGoogle Scholar5. READSELBY JT: Tobacco smoking and the ventilatory function of the lungs. Brit. Med. 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Author, Article, and Disclosure InformationAffiliations: Fresno, CaliforniaFrom the Department of Medicine, Fresno County General Hospital, 445 South Cedar Ave., Fresno, Calif.This study was supported in part by a grant from the Tuberculosis and Health Association of Fresno County, Fresno, Calif.Requests for reprints should be addressed to Roger K. Larson, M.D., 445 S. Cedar, Fresno, Calif. 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LARSON, M.D., F.A.C.P., MARTIN L. BARMAN, M.D., FRIEDRICH KUEPPERS, M.D., H. HUGH FUDENBERG, M.D.Pulmonary emphysema and alpha1-antitrypsin deficiencyManagement of patients with cor pulmonale—Acute and chronicFamilial Emphysema and Alpha 1 -Antitrypsin Deficiency 1 December 1965Volume 63, Issue 6Page: 1001-1008KeywordsBronchitisChronic bronchitisChronic obstructive pulmonary diseaseEmphysemaEtiologyGenetic determinismGenetic predispositionHospital medicinePathogenesisPulmonary function Issue Published: 1 December 1965 PDF downloadLoading ...