tbuckley/cabot-search huggingface dataset:
Social Consequences of the Acquired Immunodeficiency Syndrome
Authors: BRETT J. CASSENS
Journal: Annals of Internal Medicine (1985)

Awareness of the pertinent psychosocial dimensions of the acquired immunodeficiency syndrome (AIDS) provides researchers and clinicians with an understanding of factors impinging on their relationships with persons at risk for this disease. These observations are made from the standpoint of the American Association of Physicians for Human Rights, a national organization of gay physicians that serves as an advocate in improving health care for gay men and lesbians. Fear and uncertainty in patient care and prognosis as well as loss of confidentiality are among the stresses on gay men with AIDS. Injudicious "expert" pronouncements and sensational stories in the media heighten the fear of persons at risk for the disease as well as the fear and prejudice of the general community. Members of all communities, both heterosexual and gay, scientific and lay, should work together to eliminate social ignorance about AIDS.
Comparison of the electrocardiographic changes induced by maximam exercise testing with treadmill and cycle ergometer.
Authors: J R Wicks, J R Sutton, N B Oldridge, N L Jones
Journal: Circulation (1978)

Maximum exercise testing using treadmill walking and cycle ergometry was compared in 40 male patients who had suffered a myocardial infarction in the preceeding twelve months. Maximum oxygen uptake was on average 17% greater in the treadmill than the cycle test and maximum heart rate was also higher, but the rate pressure product (RPP) was a similar due to a higher blood pressure in the cycle ergometer test. Eleven subjects showe ST-segment depression greater than 1 min and eight subjects showed ST-segment elevation greater than 1 mm. There was a close relationship (r2 = 0.96) between the magnitude of ST-segment changes in the two tests. Four subjects showing ST depression of 1 mm in the treadmill test showed depression during the cycle ergometer test which was less than this conventionally "positive" value. In these subjects RPP was lower during cycling than in treadmill walking. With both tests maximum ST-segment changes were measured immediately on stopping exercise: resolution of ST depression was more rapid than ST elevation. The two exercise testing modes are closely comparable in their ability to reveal changes of myocardial ischemia.
Human papilloma virus linked to cervical (and other) cancers
Authors: Mitchel L. Zoler
Journal: JAMA (1983)

Human papilloma virus (HPV) has for some time been known to cause benign tumors, or warts. However, a growing body of evidence now links HPV to the genesis of some malignant tumors. The evidence of HPV's role in human cancer remains circumstantial, (although its association with squamous cell carcinomas in animals is well established). But a strong case has been made by the recent finding of genetic sequences homologous to the genome of one HPV type, HPV 16, in cells taken from women with cervical intraepithelial neoplasia (the severe form of which corresponds to carcinoma in situ) or invasive cervical cancer. These sequences were observed in 12 of 20 specimens from German patients and in 10 of 35 specimens from African and South American patients (<i>Proc Nat Acad Sci</i>, in press). "Based on these findings, we can now suggest that infection of genital tissue with HPV 16 represents a significant
Measuring the performance of health systems
Authors: J. Mulligan
Journal: BMJ (2000)

Reviews p 248 

It seems that the whole world is suddenly talking about measuring the performance of health systems. Last month the World Health Organization published its findings from a comparative study of healthcare systems.1 This time it is the turn of the Department of Health in England, which last week published the results of the second round of performance indicators for 99 health authorities and 275 NHS hospital trusts.2 Unlike last year's figures, these data will inform and shape key aspects of the government's plan for the NHS, which will be published next week.

The main message of the latest performance indicators is that health in England is continuing to improve. However, there is also compelling evidence of variation in health and healthcare performance between areas and between hospitals. For example, the proportion of patients waiting less than two hours to be admitted after attending an …
PROGNOSTIC VALUE OF STRESS ECHOCARDIOGRAPHY IN PATIENTS WITH LOW OR INTERMEDIATE SHORT TERM (10-YEAR), BUT HIGH LIFETIME (≥39%) PREDICTED RISK OF CARDIOVASCULAR DISEASE
Authors: Siu-Sun Yao, Azhar Supariwala, Sameh Mohareb, Sai Sreenija Dukkipati, Fayzan Chaudhry, Partho Sengupta, Jagat Narula, Farooq Chaudhry
Journal: Journal of the American College of Cardiology (2014)
Postpartum acquired factor VIII inhibitors
Authors: Massimo Franchini
Journal: American Journal of Hematology (2006)

Abstract The development of factor VIII autoantibodies is a rare but severe complication of pregnancy. Although the natural history of postpartum acquired hemophilia A is usually benign, with a high percentage of spontaneous remissions and a low mortality, its quick recognition is important to control bleeding episodes. Based on an analysis of the literature, this review presents the current knowledge on the pathogenesis, diagnosis, epidemiology, natural history, clinical manifestations, and therapeutic management of postpartum acquired hemophilia A. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.
PLASMAPHERESIS IN TREATMENT OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-I ASSOCIATED MYELOPATHY
Authors: Hidenori Matsuo, Mitsuhiro Tsujihata, Akira Satoh, Susumu Shirabe, Tatsufumi Nakamura, Ikuo Kinoshita, Itsuro Tomita, Kohji Shibayama, Shigenobu Nagataki
Journal: The Lancet (1988)
Health Communication In Alaska
Authors: Harold M. Schoolman
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Your speculations about physician's assistants and satellite communications in sparsely populated Alaska (227:935, 1974) read like a description of an experimental program that the National Library of Medicine and the Indian Health Service have sponsored for the past three years, as well as a blueprint for its planned expansion later this year. Since June 1971, native health aides in 26 remote villages in Alaska have had regular daily voice contact, via the ATS-1 satellite, with an Indian Health Service field hospital in Tanana. This has proved a vast improvement over regular high-frequency radio communication which, because of terrain and atmospheric disturbances, is unreliable in those parts. The experimental satellite system has been credited with saving several lives. A National Aeronautics and Space Administration satellite to be launched later this year, the ATS-F, will allow two-way video and physiological data transmission at certain sites in Alaska, in addition
B cell–specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia
Authors: Hannah M. Kerns, Byoung Y. Ryu, Brigid V. Stirling, Blythe D. Sather, Alexander Astrakhan, Stephanie Humblet-Baron, Denny Liggitt, David J. Rawlings
Journal: Blood (2010)
Are We Physicians Helpless?
Authors: Charles S. Davidson
Journal: New England Journal of Medicine (1984)

IN my lifetime, medicine and the illnesses we physicians are asked to treat have changed greatly. Many of the past scourges have gone, yet we seem to be faced not with fewer problems but with more and more. I will comment about some of these problems and then mention a few simple things each of us can do that will do no harm and, I believe, may even ameliorate a situation that is rapidly becoming difficult for each of us.We have come a long way in bringing science into medical practice, but we still have a long way to . . .
A Randomized Phase 2 Study of Erlotinib Alone and in Combination with Bortezomib in Previously Treated Advanced Non-small Cell Lung Cancer
Authors: Thomas J. Lynch, David Fenton, Vera Hirsh, David Bodkin, Edward L. Middleman, Alberto Chiappori, Balazs Halmos, Reyna Favis, Hua Liu, William L. Trepicchio, Omar Eton, Frances A. Shepherd
Journal: Journal of Thoracic Oncology (2009)
Associations Between Biomarkers and Age in the Presenilin 1 E280A Autosomal Dominant Alzheimer Disease Kindred
Authors: Adam S. Fleisher, Kewei Chen, Yakeel T. Quiroz, Laura J. Jakimovich, Madelyn Gutierrez Gomez, Carolyn M. Langois, Jessica B. S. Langbaum, Auttawut Roontiva, Pradeep Thiyyagura, Wendy Lee, Napatkamon Ayutyanont, Liliana Lopez, Sonia Moreno, Claudia Muñoz, Victoria Tirado, Natalia Acosta-Baena, Anne M. Fagan, Margarita Giraldo, Gloria Garcia, Matthew J. Huentelman, Pierre N. Tariot, Francisco Lopera, Eric M. Reiman
Journal: JAMA Neurology (2015)

Age-associated changes in brain imaging and fluid biomarkers are characterized and compared in presenilin 1 (PSEN1)E280A mutation carriers and noncarriers from the world's largest known autosomal dominant Alzheimer disease (AD) kindred.To characterize and compare age-associated changes in brain imaging and fluid biomarkers in PSEN1 E280A mutation carriers and noncarriers.Cross-sectional measures of 18F-florbetapir positron emission tomography, 18F-fludeoxyglucose positron emission tomography, structural magnetic resonance imaging, cerebrospinal fluid (CSF), and plasma biomarkers of AD were assessed from 54 PSEN1 E280A kindred members (age range, 20-59 years).We used brain mapping algorithms to compare regional cerebral metabolic rates for glucose and gray matter volumes in cognitively unimpaired mutation carriers and noncarriers. We used regression analyses to characterize associations between age and the mean cortical to pontine 18F-florbetapir standard uptake value ratios, precuneus cerebral metabolic rates for glucose, hippocampal gray matter volume, CSF Aβ1-42, total tau and phosphorylated tau181, and plasma Aβ measurements. Age at onset of progressive biomarker changes that distinguish carriers from noncarriers was estimated using best-fitting regression models.Compared with noncarriers, cognitively unimpaired mutation carriers had significantly lower precuneus cerebral metabolic rates for glucose, smaller hippocampal volume, lower CSF Aβ1-42, higher CSF total tau and phosphorylated tau181, and higher plasma Aβ1-42 measurements. Sequential changes in biomarkers were seen at age 20 years (95% CI, 14-24 years) for CSF Aβ1-42, age 16 years (95% CI, 11-24 years) for the mean cortical 18F-florbetapir standard uptake value ratio, age 15 years (95% CI, 10-24 years) for precuneus cerebral metabolic rate for glucose, age 15 years (95% CI, 7-20 years) for CSF total tau, age 13 years (95% CI, 8-19 years) for phosphorylated tau181, and age 6 years (95% CI, 1-10 years) for hippocampal volume, with cognitive decline up to 6 years before the kindred's estimated median age of 44 years (95% CI, 43-45 years) at mild cognitive impairment diagnosis. No age-associated findings were seen in plasma Aβ1-42 or Aβ1-40.This cross-sectional study provides additional information about the course of different AD biomarkers in the preclinical and clinical stages of autosomal dominant AD.
A study of the temporomandibular joint during bruxism
Authors: María S Commisso, Javier Martínez-Reina, Juana Mayo
Journal: International Journal of Oral Science (2014)

A finite element model of the temporomandibular joint (TMJ) and the human mandible was fabricated to study the effect of abnormal loading, such as awake and asleep bruxism, on the articular disc. A quasilinear viscoelastic model was used to simulate the behaviour of the disc. The viscoelastic nature of this tissue is shown to be an important factor when sustained (awake bruxism) or cyclic loading (sleep bruxism) is simulated. From the comparison of the two types of bruxism, it was seen that sustained clenching is the most detrimental activity for the TMJ disc, producing an overload that could lead to severe damage of this tissue. Extreme overload stress on cartilage during clenching can lead to significant damage to the jaw joint, researchers in Spain report. Around 85% of people suffer from awake or sleep bruxism —clenching / grinding of the jaw — at some point in their lives. Bruxism can lead to chronic pain and in extreme cases may do irreparable damage to the temporomandibular joint (TMJ). Maria Commisso and colleagues at the University of Seville built a finite element computer model of the TMJ and human mandible to examine the effect of abnormal loading stresses on the TMJ articular disc. The researchers modelled the behavior of the disc under sustained and cyclic loading, as found in awake and sleep bruxism, respectively. They found that sustained clenching in awake bruxism is the most damaging to disc cartilage.
Infectious disease in the aging
Authors: Satoru Ebihara
Journal: The Lancet Infectious Diseases (2011)

Despite of the recognition of infection as a serious health problem in older adults, textbooks on infectious diseases often do not address issues relevant to elderly and frail people. Guidelines do not always sufficiently account for individual variation among patients, with aging being one of the largest factors affecting this variation. Therefore, I have been looking forward to the updated edition of Infectious Disease in the Aging: A Clinical Handbook—the first edition, published in 2001, was an excellent review of the pertinent infectious diseases issues in the geriatric population.
Severe pulmonary arterial hypertension as initial manifestation of intravascular lymphoma: Case report
Authors: Achille Aouba, Saliou Diop, David Saadoun, Grégoire Trebbia, Françoise Vilde, Blaise Patri, Olivier Hermine
Journal: American Journal of Hematology (2005)

Intravascular lymphoma (IVL) is a rare and usually fatal disease that belongs to the class of high-grade malignant lymphomas and which is characterized by proliferation of neoplastic lymphoid cells exclusively within the lumina of small blood vessels. Its polymorphic and nonspecific clinical manifestations make antemortem diagnosis very difficult. We report herein a case of IVL revealed by fatal, precapillary, pulmonary arterial hypertension and associated with long-lasting fever. Extensive investigation of the usual causes of pulmonary arterial hypertension was negative. The diagnosis of intravascular lymphoma was made on postmortem analysis, revealing diffuse and sometimes complete obliterations of the lumina of small blood vessels by large B-cell lymphoma, including pulmonary capillaries. Thus, we propose that IVL must be added to the spectrum of etiologies of subacute pulmonary arterial hypertension, notably in the context of associated fever, both entities requiring emergency diagnosis. For this purpose, blood collected via pulmonary capillary-wedge aspiration for cytologic examination may be associated with right-sided heart catheterization when this latter procedure is suitable. Am. J. Hematol. 79:46–49, 2005. © 2005 Wiley-Liss, Inc.
Interpersonal exchange and freedom for resource acquisition
Authors: John Adamopoulos
Journal: Behavioral and Brain Sciences (2013)

Abstract The relationship of climate and monetary resources to various freedoms can be enriched if the conceptual links – “psychobehavioral adaptations” – are conceptualized more broadly as reflections of a richer cultural context that involves multiple physical and psychological resources, as proposed by social resource theory and a number of models of the emergence of social meaning.
Myocardial Production of C-Type Natriuretic Peptide in Chronic Heart Failure
Authors: Paul R. Kalra, Jonathon R. Clague, Aidan P. Bolger, Stefan D. Anker, Phillip A. Poole-Wilson, Allan D. Struthers, Andrew J. Coats
Journal: Circulation (2003)

C-type natriuretic peptide (CNP) is a vasodilator produced by the vascular endothelium. It shares structural and physiological properties with the cardiac hormones atrial natriuretic peptide and brain natriuretic peptide (BNP), but little is known about its pathophysiological role in chronic heart failure (CHF). We assessed the hypothesis that CNP is produced by the heart in patients with CHF.Myocardial CNP production was determined (difference in plasma levels between the aortic root and coronary sinus [CS]) in 9 patients undergoing right and left heart catheterization as part of their CHF assessment (all male, age 59+/-9 years; New York Heart Association class 2.2+/-0.1; left ventricular ejection fraction 29+/-5%; creatinine 105+/-8 micro mol/L [all values mean+/-SEM]). BNP, established as originating from myocardium, was assessed from the same samples as a positive control. Analyses were performed by a blinded operator using a standard competitive radioimmunoassay kit (Peninsula Laboratories, Bachem Ltd UK). A step-up (29%) in plasma CNP concentration was found from the aorta to the CS (3.55+/-1.53 versus 4.59+/-1.54 pg/mL, respectively; P=0.035). The mean increase in CNP was 0.90+/-0.35 pg/mL (range 0.05 to 2.80 pg/mL). BNP levels increased by 57% from aorta to CS (86.0+/-20.5 versus 135.0+/-42.2 pg/mL; P=0.01). CS CNP levels correlated with mean pulmonary capillary wedge pressure (r=0.82, P=0.007).We have shown that CNP is produced by the heart in patients with CHF. Although further evaluation is required to define its full pathophysiological role in this condition, CNP may represent an important new local mediator in the heart.
Analysis of mutagens from cooked foods by directly combined liquid chromatography-mass spectrometry.
Authors: C G Edmonds, S K Sethi, Z Yamaizumi, H Kasai, S Nishimura, J A McCloskey
Journal: Environmental Health Perspectives (1986)

Directly combined high performance liquid chromatography-mass spectrometry (LC/MS) has been studied as a method of analysis of heterocyclic aromatic mutagens in cooked foods, in the parts per billion concentration range. Identification and semiquantitative estimation of mutagens is based on accurate measurement of chromatographic retention (k') and molecular weight-selective detection of mutagens, which are protonated during passage of the chromatographic eluant into a thermospray interface of a quadrupole mass spectrometer. Standard chromatographic retention (k') values in two reversed-phase systems and data from thermospray mass spectra from nine mutagens are reported. An isolation scheme employing CH3OH extraction, acid-base partition, cellulose-trisulfo-Cu-phthalocyanine adsorption, and normal-phase HPLC was used prior to LC/MS analysis. Initial applications have been demonstrated in the analysis of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in broiled salmon flesh. Levels measured were estimated to be in the range 0.2 to 0.4 microgram/kg IQ and 0.4 to 0.9 microgram/kg MeIQ. The method is judged to be generally applicable with minimal sample prefractionation to detection of mutagens at the parts per billion level in cooked foods.
Medical Disorders in Drug Addicts
Authors: Abraham G. White
Journal: JAMA (1973)

The cases of 200 patients admitted to the Bernstein Institute Medical Inpatient Unit (Beth Israel Medical Center, New York) were analyzed according to epidemiologic, demographic, and diagnostic characteristics. There were 129 men and 71 women; 126 patients were below 30 years of age and the youngest was 15 years old. Sixty-eight patients were white; 82, black; 49, Hispanic; and 1, Oriental. Reasons for admission were the following: acute hepatitis (30.5%), infections (27.5%), detoxification (11.5%), diabetes mellitus (7.5%), pulmonary disease (6.0%), overdose (5.0%), cardiovascular disease (4.0%), gastrointestinal disease (3.5%), and venereal disease (3.5%).
To “grow” and what “to grow,” that is one question
Authors: Juana M. Liceras
Journal: Behavioral and Brain Sciences (1996)

Abstract L2 learners may access UG principles because these are realized in all natural languages. Since this is not the case for the parametrized aspects of language, parameter setting may be progressively replaced by restructuring mechanisms which are specifically related to the process of representational redescription because L2 learners are not sensitive to the [±] features which define parameters.
Electroconvulsive Therapy
Authors: Max Fink, Michael Alan Taylor
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TH2 cytokine–associated transcription factors in atopic and nonatopic asthma: Evidence for differential signal transducer and activator of transcription 6 expression
Authors: Pota Christodoulopoulos, Lisa Cameron, Yutaka Nakamura, Catherine Lemière, Shigeo Muro, Mario Dugas, Louis-Philippe Boulet, Michel Laviolette, Ron Olivenstein, Qutayba Hamid
Journal: Journal of Allergy and Clinical Immunology (2001)
Bullous lichen sclerosus with chronic hepatitis C virus infection
Authors: S. Boulinguez, P. Bernard, J.P. Lacour, T. Nicot, C. Bedane, J.P. Ortonne, J.M. Bonnetblanc
Journal: British Journal of Dermatology (1997)

Journal Article Bullous lichen sclerosus with chronic hepatitis C virus infection Get access S. Boulinguez, S. Boulinguez Department of Dermatology, University Hospital Dupuytren, Limoges, France Search for other works by this author on: Oxford Academic Google Scholar P. Bernard, P. Bernard Department of Dermatology, University Hospital Dupuytren, Limoges, France Search for other works by this author on: Oxford Academic Google Scholar J.P. Lacour, J.P. Lacour Department of Dermatology, University Hospital, Nice, France Search for other works by this author on: Oxford Academic Google Scholar T. Nicot, T. Nicot †Laboratory of Virology, University Hospital Dupuytren, Limoges, France Search for other works by this author on: Oxford Academic Google Scholar C. Bedane, C. Bedane Department of Dermatology, University Hospital Dupuytren, Limoges, France Search for other works by this author on: Oxford Academic Google Scholar J.P. Ortonne, J.P. Ortonne Department of Dermatology, University Hospital, Nice, France Search for other works by this author on: Oxford Academic Google Scholar J.M. Bonnetblanc J.M. Bonnetblanc Department of Dermatology, University Hospital Dupuytren, Limoges, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 3, 1 September 1997, Pages 474–476, https://doi.org/10.1111/j.1365-2133.1997.tb03767.x Published: 01 September 1997