tbuckley/cabot-search huggingface dataset:
Bringing Professionalism to the Bedside
Authors: Christine Laine, Harold C. Sox
Journal: Annals of Internal Medicine (2004)

Editorials2 November 2004Bringing Professionalism to the BedsideChristine Laine, MD, MPH, Senior Deputy Editor and Harold C. Sox, MD, EditorChristine Laine, MD, MPH, Senior Deputy EditorSearch for more papers by this author and Harold C. Sox, MD, EditorSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-9-200411020-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In February 2002, the American Board of Internal Medicine Foundation, the American College of Physicians Foundation, and the European Federation of Internal Medicine published in Annals of Internal Medicine and The Lancet a document titled the Charter on Medical Professionalism (1). The Charter provides an ethical, educational, and practical framework to guide physicians in the practice of medicine and in their relationships with patients, colleagues, and society. The practical application of these principles is the last joist in this framework, and it is the most difficult to convey in a document such as a Charter. Most physicians would find the ...References1. Medical professionalism in the new millennium: a physician charter. Ann Intern Med. 2002;136:243-6. [PMID: 11827500] LinkGoogle Scholar2. Helms E. A lesson from the third year. Ann Intern Med. 2004;141:736-7. LinkGoogle Scholar3. Francis CK. Professionalism and the medical student [Editorial]. Ann Intern Med. 2004;141:735-6. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Customer Service, American College of Physicians, 190 N. Independence Mall West, Philadelphia, PA 19106-1572.Current Author Addresses: Drs. Laine and Sox: American College of Physicians, 190 N. Independence Mall West, Philadelphia, PA 19106-1572. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoProfessionalism and the Medical Student Charles K. Francis A Lesson from the Third Year Eric Helms Professionalism and the Medical Student Nancy R. Angoff Metrics Cited ByProfessionalism and the Medical StudentNancy R. Angoff, MD, MPH, MEd 2 November 2004Volume 141, Issue 9Page: 735KeywordsEmotions ePublished: 2 November 2004 Issue Published: 2 November 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
FINGERNAIL GROWTH IN IDIOPATHIC AND PSORIATIC ONYCHOLYSIS
Authors: R. P. R. DAWBER, P. D. SAMMAN, EVA BOTTOMS
Journal: British Journal of Dermatology (1971)

Journal Article FINGERNAIL GROWTH IN IDIOPATHIC AND PSORIATIC ONYCHOLYSIS Get access R. P. R. DAWBER, R. P. R. DAWBER St John's Hospital for Diseases of the Skin, Lisle Street, London, W.C.2, and University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne (Dr Bottoms) Search for other works by this author on: Oxford Academic Google Scholar P. D. SAMMAN, P. D. SAMMAN St John's Hospital for Diseases of the Skin, Lisle Street, London, W.C.2, and University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne (Dr Bottoms) Search for other works by this author on: Oxford Academic Google Scholar EVA BOTTOMS EVA BOTTOMS St John's Hospital for Diseases of the Skin, Lisle Street, London, W.C.2, and University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne (Dr Bottoms) Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue 6, 1 December 1971, Pages 558–560, https://doi.org/10.1111/j.1365-2133.1971.tb14082.x Published: 01 December 1971 Article history Accepted: 26 May 1971 Published: 01 December 1971
Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII.
Authors: F Takizawa, M Adamczewski, J P Kinet
Journal: The Journal of Experimental Medicine (1992)

In addition to their well characterized high affinity immunoglobulin E (IgE) receptors (Fc epsilon RI) mast cells have long been suspected to express undefined Fc receptors capable of binding IgE with low affinity. In this paper, we show that Fc gamma RII and Fc gamma RIII, but not Mac-2, on mouse mast cells and macrophages bind IgE-immune complexes. This binding is efficiently competed by 2.4G2, a monoclonal antibody against the extracellular homologous region of both Fc gamma RII and Fc gamma RIII. Furthermore, IgE-immune complexes bind specifically to Fc gamma RII or Fc gamma RIII transfected into COS-7 cells. The association constants of IgE binding estimated from competition experiments are about 3.1 x 10(5) M-1 for Fc gamma RII, and 4.8 x 10(5) M-1 for Fc gamma RIII. Engagement of Fc gamma RII and Fc gamma RIII with IgE-immune complexes (after blocking access to Fc epsilon RI) or with IgG-immune complexes triggers C57.1 mouse mast cells to release serotonin. This release is inhibited by 2.4G2, and at maximum, reaches 30-40% of the intracellular content, about half of the maximal release (60-80%) obtained after Fc epsilon RI engagement. These data demonstrate that mouse Fc gamma RII and Fc gamma RIII are not isotype specific, and that the binding of IgE-immune complexes to these receptors induces cell activation.
Invasive pulmonary aspergillosis is a frequent complication of critically ill H1N1 patients: a retrospective study
Authors: Joost Wauters, Ingrid Baar, Philippe Meersseman, Wouter Meersseman, Karolien Dams, Rudi De Paep, Katrien Lagrou, Alexander Wilmer, Philippe Jorens, Greet Hermans
Journal: Intensive Care Medicine (2012)
AMEBIC ABSCESS OF THE FOOT
Authors: E. L. Nowicki
Journal: JAMA (1952)

<h3>To the Editor:</h3> —Amebic infections of the skin have been described by some authors following the surgical treatment of amebic abscess of the liver (Heimburger, L. F.:<i>Arch. Dermat. &amp; Syph.</i><b>11:</b>49, 1925, and Van Hoof, L.:<i>Ann. Soc. belge de méd. trop.</i><b>6:</b>45, 1926), the drainage after appendectomy (Cole, W. H., and Heideman, M. L.:<i>J. A. M. A.</i><b>92:</b>537 [Feb. 16] 1929), or as anal amebiasis (Kouri, P.; Iriondo, M., and Peraza, J. A.:<i>Rev. Kuba</i><b>5:</b>93, 1949). I have seen two patients with amebic infection of the foot, without any relation to intestinal amebiasis. The special conditions of the country must be mentioned: a very high percentage of the population are amebic "cystpassers" and deposit the stools in the yards between the houses. The result is that in the dry season the dust contains the amebic cyst. One patient, a 32-year-old Italian welder,
The Absorption of Subcutaneously Injected Short-Acting Soluble Insulin: Influence of Injection Technique and Concentration
Authors: Per Hildebrandt, Leif Sestoft, Steen L Nielsen
Journal: Diabetes Care (1983)

The effect of injection technique on the absorption of subcutaneously injected short-acting insulin [125I-labeled Actrapid (MC), Novo, Copenhagen, Denmark] was investigated in insulin-dependent diabetic patients. In one side of the abdomen insulin was given with a fixed standard technique. In the other side of the abdomen the temperature of the injected insulin, the depth of injection, and the duration of injection were varied. Furthermore, we compared the absorption of U40 and U100 insulin by giving either 8 U of the two insulins or 0.1 ml of both insulins simultaneously to the patients in either side of the abdomen. With regard to the injection technique the only significant finding was a faster absorption rate with deep (12 mm) than with superficial (3 mm) injection. The absorption of U100 insulin was significantly slower than of U40 insulin, when given in the same amount (8 U) as well as in the same volume (0.1 ml).
Health and Economic Benefits of Early Vaccination and Nonpharmaceutical Interventions for a Human Influenza A (H7N9) Pandemic
Authors: Nayer Khazeni, David W. Hutton, Cassandra I.F. Collins, Alan M. Garber, Douglas K. Owens
Journal: Annals of Internal Medicine (2014)

Vaccination for the 2009 pandemic did not occur until late in the outbreak, which limited its benefits. Influenza A (H7N9) is causing increasing morbidity and mortality in China, and researchers have modified the A (H5N1) virus to transmit via aerosol, which again heightens concerns about pandemic influenza preparedness.To determine how quickly vaccination should be completed to reduce infections, deaths, and health care costs in a pandemic with characteristics similar to influenza A (H7N9) and A (H5N1).Dynamic transmission model to estimate health and economic consequences of a severe influenza pandemic in a large metropolitan city.Literature and expert opinion.Residents of a U.S. metropolitan city with characteristics similar to New York City.Lifetime.Societal.Vaccination of 30% of the population at 4 or 6 months.Infections and deaths averted and cost-effectiveness.In 12 months, 48 254 persons would die. Vaccinating at 9 months would avert 2365 of these deaths. Vaccinating at 6 months would save 5775 additional lives and $51 million at a city level. Accelerating delivery to 4 months would save an additional 5633 lives and $50 million.If vaccination were delayed for 9 months, reducing contacts by 8% through nonpharmaceutical interventions would yield a similar reduction in infections and deaths as vaccination at 4 months.The model is not designed to evaluate programs targeting specific populations, such as children or persons with comorbid conditions.Vaccination in an influenza A (H7N9) pandemic would need to be completed much faster than in 2009 to substantially reduce morbidity, mortality, and health care costs. Maximizing non-pharmaceutical interventions can substantially mitigate the pandemic until a matched vaccine becomes available.Agency for Healthcare Research and Quality, National Institutes of Health, and Department of Veterans Affairs.
Growth Hormone Heterogeneity: Genes, Isohormones, Variants, and Binding Proteins
Authors: GERHARD BAUMANN
Journal: Endocrine Reviews (1991)

Human GH represents a family of proteins rather than a single hormone. The circulation contains a bewildering array of GH forms, including several monomeric variants, their homo- and heteropolymers, fragments, and complexes with at least two BPs. The net biological activity of this mixture is difficult to predict, as the various molecular forms interact as partial agonists and/or antagonists at the receptor level. The number of GH forms that can be counted in plasma exceeds 100. Table 5 attempts to illustrate what is known and provide estimates for circulating variants. It does not include GH-V and its variants, which have to be added in pregnancy. Of note, what is commonly understood as "plasma GH," i.e. free monomeric 22K, represents only 21% of total immunoreactivity in plasma. In view of this complicated picture, it should be no surprise that different assays of plasma GH yield different results (107, 108, 290). While immunoassays are relatively unaffected by the BPs (291), receptor assays are seriously affected by the high affinity BP (261). Immunoassays, particularly of the monoclonal variety, are vulnerable to differential recognition of molecular variants depending on the unique epitope specificity of the antibody used. Polyclonal assays are more robust in this regard because of "epitope averaging" among the wide spectrum of epitope specificities present in the antibody population. Future work should aim at developing antibodies that are specific for individual GH variants. Such molecular probes will be helpful not only in standardizing immunoassays, but also in delineating the biological role of the various GH forms. The physiological significance of the numerous GH forms (or of the BPs) is still largely unknown. Progress in this area has been hampered, on the one hand, by the unavailability of pure GH variants in quantities sufficient for biological studies, and, on the other, by a certain lack of interest stemming from suspicions about artifacts. The recent resurgence of interest in GH and in its receptor and BPs should also refocus attention on the various molecular forms. Thus far, this interest has been largely confined to monomeric 22K, which is certainly effective for its original intended purpose, namely growth promotion. Whether 22K is sufficient for optimal growth and development, or whether it can fulfill all the functions of the GH family is unknown. It can be argued that evolutionarily conserved GH variants probably have biological importance.(ABSTRACT TRUNCATED AT 400 WORDS)
COMP-Angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury
Authors: Duk Hoon Kim, Yu Jin Jung, Ae Sin Lee, Sik Lee, Kyung Pyo Kang, Tae Hwan Lee, Sang Yong Lee, Kyu Yun Jang, Woo Sung Moon, Kyu-Sil Choi, Kwon-Ha Yoon, Mi Jeong Sung, Sung Kwang Park, Won Kim
Journal: Kidney International (2009)
US Military Smallpox Vaccination Program Experience
Authors: John D. Grabenstein
Journal: JAMA (2003)

The United States recently implemented smallpox vaccination of selected military personnel in a national program of preparedness against use of smallpox as a biological weapon. The resumption of smallpox vaccinations raises important questions regarding implementation and safety.To describe the US military smallpox vaccination program.Descriptive study of the vaccination program from its inception on December 13, 2002, through May 28, 2003.US Department of Defense (DoD) fixed and field medical treatment facilities on multiple continents and ships at sea.US service members and DoD civilian workers eligible for smallpox vaccination.Numbers of vaccinations and rates of vaccination exemptions, symptoms, and adverse events. Data were collected via reports to headquarters and rigorous surveillance for sentinel events.In 5.5 months, the DoD administered 450 293 smallpox vaccinations (70.5% primary vaccinees and 29.5% revaccinees). In 2 settings, 0.5% and 3.0% of vaccine recipients needed short-term sick leave. Most adverse events occurred at rates below historical rates. One case of encephalitis and 37 cases of acute myopericarditis developed after vaccination; all cases recovered. Among 19 461 worker-months of clinical contact, there were no cases of transmission of vaccinia from worker to patient, no cases of eczema vaccinatum or progressive vaccinia, and no attributed deaths.Mass smallpox vaccinations can be conducted safely with very low rates of serious adverse events. Program implementation emphasized human factors: careful staff training, contraindication screening, recipient education, and attention to bandaging. Our experience suggests that broad smallpox vaccination programs may be implemented with fewer serious adverse events than previously believed.
A new method of auditing surgical mortality rates: application to a group of elderly general surgical patients.
Authors: D G Seymour, R Pringle
Journal: BMJ (1982)

In a prospective study of 505 patients aged 65 years or over admitted to a general surgical unit the overall hospital mortality rate was 14.5% and the postoperative mortality rate 12.0%. These rates fell to 3.6% and 5.8% respectively when deaths in non-viable patients were excluded from the analysis. An audit of surgical outcome that fails to identify non-viable patients is therefore potentially misleading. A standardised system of reporting surgical mortality is proposed to aid the comparison of results from different units. The key elements of this system are (a) the separation of the results from non-viable and potentially viable patients; (b) the consideration of both operative and non-operative mortality; (c) the differentiation between medical and surgical causes of postoperative mortality; and (d) the identification of patients who are discharged from the unit but who have residual malignancy. Data presented in such a way should be of direct relevance to surgeons and physicians who are seeking ways of improving the service provided for surgical patients of all ages.
CPAP for acute cardiogenic pulmonary oedema from out-of-hospital to cardiac intensive care unit: a randomised multicentre study
Authors: Laurent Ducros, Damien Logeart, Eric Vicaut, Patrick Henry, Patrick Plaisance, Jean-Philippe Collet, Claire Broche, Papa Gueye, Muriel Vergne, David Goetgheber, Pierre-Yves Pennec, Vanessa Belpomme, Jean-Michel Tartière, Sophie Lagarde, Marius Placente, Marie-Laurence Fievet, Gilles Montalescot, Didier Payen
Journal: Intensive Care Medicine (2011)
F-18 FDG PET/CT Showing Bilateral Breast Involvement in Acute Myeloid Leukemia Relapse
Authors: Christian von Falck, Florian Laenger, Wolfram H. Knapp, Michael Galanski
Journal: Clinical Nuclear Medicine (2009)

Isolated extramedullary relapse with involvement of the breasts by acute myeloid leukemia (AML) after allogeneic stem cell transplantation is an uncommon event. We here report the case of a 27-year-old female patient, who was diagnosed with high-risk AML (FAB M5, complex karyotype). Fourteen months after successful bone marrow transplantation, she presented with asymptomatic masses in both breasts. Ultrasound-guided biopsy was performed and histopathology revealed relapsing AML. F-18 FDG PET/CT was performed for whole-body staging and intense multifocal uptake was seen in both breasts and in the abdomen. Isolated extramedullary disease recurrence was confirmed by bone marrow biopsy.
Development and validation of Korean breast cancer risk assessment tool.
Authors: M Chang
Journal: Cancer Research (2009)

Abstract Abstract #4083 Introduction: The NCI breast cancer risk assessment tool of Gail model was used for counseling and chemoprevention of western breast cancer. Because Korean women have different incidence rates and risk factors, the Gail model can not properly estimate the breast cancer risk for Korean women. The author developed and validated a Korean breast cancer risk assessment tool, which would display the absolute breast cancer risks of Korean women.&amp;#x2028; Methods: A risk model was established from a case-control study of 1687 cases of invasive carcinoma and 1238 controls. The risk factors selected were age, family history of the first and second relatives, body mass index, age at the first delivery, breast-feeding and a special test on the breasts. A baseline risk and individual breast cancer risk were calculated by a competing risk analysis. A discriminatory accuracy of the program was evaluated by a receiver operating characteristic (ROC) curve analysis.&amp;#x2028; Results: The risk assessment tool was developed in the Internet web page, http://home.dankook.ac.kr/breast/brca/brca-e.htm. It calculated the relative risk and the estimated absolute risks following 5, 10 years and up to age 64, 74. The estimated risks of Korean women using this tool were less than the result of NCI risk assessment tool. The risk of breast cancer was highest in the age of forties. In the discriminatory accuracy, the area under curve (AUC) was 0.587. The curve presented a tendency of high specificity and low sensitivity.&amp;#x2028; Conclusion: A web-based breast cancer risk assessment tool was developed for Korean women. This program had a limited discriminatory accuracy, but would be useful for the assessment of individual breast cancer risks, the selection of screening tools and preventive options of risk reduction for Korean women. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4083.
James Mellis Dunbar
Authors: J. A Dunbar
Journal: BMJ (2003)

Formerly director Central Clinical and Public Health Laboratory, University of Leiden, Netherlands (b Ammanford 1923; q St Andrews 1946; MD, FRCPath), died from pneumonia on 11 June 2003.    ![][1] 

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Controversy over new editor at New England Journal of Medicine
Authors: S. Gottlieb
Journal: BMJ (2000)

The Massachusetts Medical Society has named a Boston pulmonary specialist as the new editor of the New England Journal of Medicine, opening a new chapter in a struggle over the journal's control that began more than a year ago with the departure of the journal's long standing editor Dr Jerome Kassirer.

Dr Jeffrey Drazen, aged 53, who carries out research into asthma at Brigham and Women's Hospital, is expected to take the helm of the medical journal this summer. Dr Drazen has led the pulmonary division …
Internal Mammary Artery Grafts Without Optical Assistance
Authors: FLOYD D. LOOP, NICK SPAMPINATO, WAYNE SIEGEL, DONALD B. EFFLER
Journal: Circulation (1973)

Internal mammary artery (IMA) grafts were performed without optical assistance in 175 consecutive patients during a 17-month period. The predominant indications were angina pectoris and the angiographic evidence of a 70% or greater obstruction in one or more major coronary arteries. Eight patients were considered to be in New York Heart Association functional class I, 63 class II, 71 class III, and 33 class IV before the operation. Forty per cent had three major vessels obstructed, and 33% had double vessel disease. IMA grafts were constructed to the anterior descending artery in 151 patients, diagonal branch in 22, and circumflex in two. Two of the 175 and three additional patients had free IMA grafts in the aortocoronary position. Saphenous vein grafts were combined with IMA grafts in 61%. One hospital death occurred, a 0.6% operative mortality. Late clinical results were analyzed in the first 100 patients. Eighty-four of 99 have had complete remission of angina, and 12 are improved. Repeat arteriograms in 65 patients show 65 of 67 IMA grafts open (97%) and 56 (85%) of 66 saphenous vein grafts patent after an average interval of four months. These early clinical and angiographic results are encouraging and indicate that the higher IMA patency may result from less size discrepancy between the graft and the coronary artery. The addition of the technically more complicated IMA graft to direct revascularization does not increase morbidity or mortality.