tbuckley/cabot-search huggingface dataset:
Different Change in Lipoprotein(a) Levels From Lipid Levels of Other Lipoproteins With Improved Glycemie Control in Patients With NIDDM
Authors: Toru Kikuchi, Tomio Onuma, Michitaka Shimura, Masahiro Tsutsui, Akitoshi Boku, Jun Matsui, Kazuo Takebe
Journal: Diabetes Care (1994)

To evaluate change both in lipoprotein(a) [Lp(a)] and lipid levels in other lipoproteins in non-insulin-dependent diabetes mellitus (NIDDM) after short-term improvement of glycemic control.We compared Lp(a) levels in 210 NIDDM patients with those in 46 control subjects and evaluated the relationship between glycemic control and Lp(a) levels in diabetic patients. In addition, changes in Lp(a) levels and lipid levels were assessed after the improvement of glycemic control in 54 poorly controlled NIDDM patients.In NIDDM, Lp(a) levels in all patients, 62 patients with HbA1c < 6.0%, and 75 patients with HbA1c between 6.0 and 8.0%, were significantly higher than those in control subjects (19.1 [1.7-106.6], 19.2 [6.0-106.6], and 20.3 [2.7-75.3] vs. 15.4 [2.0-61.7] mg/dl, median [range], P < 0.05). Lp(a) levels in 73 patients with HbA1c of > or = 8.0% (18.7 [1.7-58.8] mg/dl) were not significantly different from those in control subjects. After glycemic control, lipid levels in plasma and in other lipoproteins fell significantly, but Lp(a) did not change (from 18.3 [1.7-58.8] to 18.4 [6.6-95.3] mg/dl). Changes in lipid levels, including Lp(a), did not correlate with those in fasting plasma glucose or HbA1c.These results suggest that elevated Lp(a) levels do not reflect poor glycemic control and that Lp(a) levels are independent of lipid levels in other lipoproteins after improved glycemic control in NIDDM.
Making decisions about hormone replacement therapy: Bisphosphonates should not be recommended for women aged 50
Authors: S. M Ott
Journal: BMJ (2003)

EDITOR—Many people, including Rymer et al in their clinical review,1 say that bisphosphonates can be used instead of oestrogen to prevent osteoporotic fractures. Clinical trials of bisphosphonates in perimenopausal women have shown …
New models of collaboration in genome-wide association studies: the Genetic Association Information Network
Authors: Teri A Manolio, Laura Lyman Rodriguez, Lisa Brooks, Gonçalo Abecasis, Dennis Ballinger, Mark Daly, Peter Donnelly, Stephen V Faraone, Kelly Frazer, Stacey Gabriel, Pablo Gejman, Alan Guttmacher, Emily L Harris, Thomas Insel, John R Kelsoe, Eric Lander, Norma McCowin, Matthew D Mailman, Elizabeth Nabel, James Ostell, Elizabeth Pugh, Stephen Sherry, Patrick F Sullivan, John F Thompson, James Warram, David Wholley, Patrice M Milos, Francis S Collins
Journal: Nature Genetics (2007)
Neuroleptic Malignant Syndrome: Response to Dantrolene Sodium
Authors: DAVID C. MAY
Journal: Annals of Internal Medicine (1983)

The neuroleptic malignant syndrome is an uncommon and potentially lethal complication of treatment with antipsychotic medication (1). This syndrome is characterized by severe fever, altered mental status, autonomic instability, and generalized skeletal muscle rigidity. Also, leukocytosis and elevations in creatine kinase may be prominent. To date, treatment has consisted mainly of supportive measures (1-5). Recently, attention has been drawn to the similarity between the neuroleptic malignant syndrome and malignant hyperthermia, a pharmacogenetic disorder of skeletal muscle (1). Patients with malignant hyperthermia are susceptible to an acute, life-threatening, hyperthermic reaction to certain pharmacologic agents (6). Dantrolene sodium has been used successfully
Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1
Authors: Ute Raffetseder, Thomas Rauen, Sonja Djudjaj, Matthias Kretzler, Abdelaziz En-Nia, Frank Tacke, Henning W. Zimmermann, Peter J. Nelson, Björn C. Frye, Jürgen Floege, Ioannis Stefanidis, Christian Weber, Peter R. Mertens
Journal: Kidney International (2008)
Nerve Conduction Abnormalities in Untreated Maturity-Onset Diabetes: Relation to Levels of Fasting Plasma Glucose and Glycosylated Hemoglobin
Authors: Ronald J. Graf, Jeffrey B. Halter, Eugen Halar, Daniel Porte
Journal: Annals of Internal Medicine (1979)

The role of metabolic abnormalities in the development of diabetic neuropathy is controversial. To investigate the influence of hyperglycemia on nerve conduction, we studied 20 untreated maturity-onset diabetic patients and 23 normal control subjects of similar age. Nerve conduction velocity of motor (median, peroneal, and tibial) and sensory (median and sural) nerves in diabetic patients was significantly slowed and H-reflex latency time prolonged. Levels of fasting plasma glucose in diabetic subjects were correlated with slowed motor conduction velocity of the median, peroneal, and tibial nerves but not with sensory nerve conduction velocities. Levels of glycosylated hemoglobin, an index of long-term glycemia, were correlated with slowing of peroneal motor conduction velocity in diabetic patients. These associations could not be explained by patient age or duration of diabetes. These findings suggest that the degree of hyperglycemia of untreated maturity-onset diabetes contributes to the motor nerve conduction abnormalities in this disease.
Epigenetic Silencing of miR-137 Is an Early Event in Colorectal Carcinogenesis
Authors: Francesc Balaguer, Alexander Link, Juan Jose Lozano, Miriam Cuatrecasas, Takeshi Nagasaka, C. Richard Boland, Ajay Goel
Journal: Cancer Research (2010)

Abstract Global downregulation of microRNAs (miRNA) is a common feature in colorectal cancer (CRC). Whereas CpG island hypermethylation constitutes a mechanism for miRNA silencing, this field largely remains unexplored. Herein, we describe the epigenetic regulation of miR-137 and its contribution to colorectal carcinogenesis. We determined the methylation status of miR-137 CpG island in a panel of six CRC cell lines and 409 colorectal tissues [21 normal colonic mucosa from healthy individuals (N-N), 160 primary CRC tissues and their corresponding normal mucosa (N-C), and 68 adenomas]. TaqMan reverse transcription-PCR and in situ hybridization were used to analyze miR-137 expression. In vitro functional analysis of miR-137 was performed. Gene targets of miR-137 were identified using a combination of bioinformatic and transcriptomic approaches. We experimentally validated the miRNA:mRNA interactions. Methylation of the miR-137 CpG island was a cancer-specific event and was frequently observed in CRC cell lines (100%), adenomas (82.3%), and CRC (81.4%), but not in N-C (14.4%; P &amp;lt; 0.0001 for CRC) and N-N (4.7%; P &amp;lt; 0.0001 for CRC). Expression of miR-137 was restricted to the colonocytes in normal mucosa and inversely correlated with the level of methylation. Transfection of miR-137 precursor in CRC cells significantly inhibited cell proliferation. Gene expression profiling after miR-137 transfection discovered novel potential mRNA targets. We validated the interaction between miR-137 and LSD-1. Our data indicate that miR-137 acts as a tumor suppressor in the colon and is frequently silenced by promoter hypermethylation. Methylation silencing of miR-137 in colorectal adenomas suggests it to be an early event, which has prognostic and therapeutic implications. Cancer Res; 70(16); 6609–18. ©2010 AACR.
The Uterine Doughnut: Potential Pitfall for Technetium-99m Gastrointestinal Bleeding Study
Authors: LAWRENCE C. SWAYNE
Journal: Clinical Nuclear Medicine (1989)

A case of intense uterine hyperemia secondary to recent pregnancy, the so-called uterine “doughnut” sign, is presented as a potential pitfall in the evaluation of gastrointestinal bleeding. Delayed imaging helped in evaluating the lack of serial change in appearance and the failure of progression of the scintigraphic abnormality.
A Randomized Study of Outpatient Treatment with Ceftriaxone for Selected Febrile Children with Sickle Cell Disease
Authors: Judith A. Wilimas, Patricia M. Flynn, Sylvia Harris, Sara W. Day, Ralph Smith, P. Joan Chesney, John H. Rodman, Jose M. Eguiguren, Diane L. Fairclough, Winfred C. Wang
Journal: New England Journal of Medicine (1993)

Because of their susceptibility to pneumococcal sepsis, children with sickle cell disease and fever are usually hospitalized for antibiotic therapy. Outpatient treatment may be a safe and less expensive alternative for selected patients.
Color categories and biology: Considerations from molecular genetics, neurobiology, and evolutionary theory
Authors: Stephen L. Zegura
Journal: Behavioral and Brain Sciences (1997)

Evidence from molecular genetics bolsters the claim that color is not a perceptuolinguistic and behavioral universal. Neurobiology continues to fill in many details about the flow of color information from photon reception to central processing in the brain. Humans have the most acute color vision in the biosphere because of natural selection and adaptation, not coincidence.
Portomesenteric Thrombosis Following Laparoscopic Bariatric Surgery
Authors: David Goitein, Ibrahim Matter, Asnat Raziel, Andrei Keidar, David Hazzan, Uri Rimon, Nasser Sakran
Journal: JAMA Surgery (2012)

To describe the incidence of, the patterns of clinical presentation of, and the reasons for portomesenteric vein thrombosis among patients who underwent laparoscopic bariatric surgery.Retrospective, multicenter study.Six academic bariatric centers.Morbidly obese patients diagnosed with portomesenteric vein thrombosis following laparoscopic bariatric surgery between January 2007 and June 2012.Clinical presentation, diagnostic measures used, treatments employed, outcome, and hematologic workup of patients.Of 5706 patients who underwent laparoscopic bariatric surgery, 17 (0.3%) had portomesenteric vein thrombosis, 16 after sleeve gastrectomy and 1 following adjustable gastric banding. Seven patients were women, the mean age was 38 years, and the mean body mass index was 44.3. The median time to presentation was 10.1 days, and the median time to diagnosis was 11.7 days. New-onset epigastric pain was present in all patients, whereas other signs and symptoms were sporadically found. Computed tomography was performed and was diagnostic in 16 cases. Ultrasonography was used for 9 patients, and positive results were found for 8 of these patients. Patients were treated by anticoagulation with subcutaneous low-molecular-weight heparin (n = 15) or intravenous heparin (n = 2), followed by warfarin sodium. One patient underwent transhepatic portal infusion of streptokinase. Three patients required surgery: laparoscopic splenectomy due to infarct and abscess for 1 patient and laparotomy for 2 patients (with necrotic small-bowl resection for 1 of these patients). There were no deaths.Portomesenteric vein thrombosis is rare after laparoscopic bariatric surgery. Familiarity with this dangerous entity is important. Prompt diagnosis and care, initiated by a high index of suspicion, is crucial.
Quantification of atopy and the probability of rhinitis in preschool children: a population‐based birth cohort study
Authors: S. Marinho, A. Simpson, L. Söderström, A. Woodcock, S. Ahlstedt, A. Custovic
Journal: Allergy (2007)

Atopy quantification using IgE levels/skin test diameter (SPT-MWD) may better predict the expression of rhinitis than using atopy as a dichotomous variable.To investigate the association between the presence, temporal pattern and severity of rhinitis in preschool children and specific IgE levels/SPT-MWDs.Children were followed prospectively to age 5 years in a whole-population birth cohort study. We administered questionnaires (n = 815), skin prick tested children (n = 717) and measured specific serum IgE (n = 478) to inhalant and food allergens. Main outcomes were current rhinitis (CR) and current rhinoconjunctivitis (CRC).The prevalence of CR and CRC was 26.1% and 12.1%, respectively. The risk of CR and CRC increased significantly with increasing IgE to grass, mite and cat; CRC was also associated with increasing IgE to dog and peanut. Similarly, increasing SPT-MWDs to inhalant allergens were significantly associated with CR and CRC. This association was also shown for grass within the group of atopic children. Perennial and seasonal rhinitis were associated with increasing IgE/SPT-MWD to mite and grass, respectively. Moderate/severe rhinitis was associated with increasing IgE/SPT-MWD to grass. In a multivariate analysis, increasing levels of IgE/SPT-MWD to grass were the strongest independent predictors of both CR (for IgE: OR 1.42, 95% CI 1.23-1.64, P < 0.001) and CRC (for IgE: 1.51, 1.30-1.76, P < 0.001).The probability of CR/CRC increases with increasing specific IgE levels or SPT-MWD. With respect to allergic rhinitis, the absolute levels of specific IgE antibody or the size of SPT wheal offer more information than just the presence/absence of sensitization.
Abstract 2088: Kindlin-3 enhances breast cancer metastasis through upregulation of Twist-mediated tumor angiogenesis
Authors: Khalid Sossey-Alaoui, Elzbieta Pluskota, Gangarao Davuluri, Katarzyna Bialkowska, Mitali Das, Daniel Lindner, Edward F. Plow
Journal: Cancer Research (2014)

Abstract The FERM domain containing protein, Kindlin-3, has been recognized as a major regulator of integrin function in hematopoietic cells but its role in neoplasia is totally unknown. We have examined the relationship between Kindlin-3 and breast cancer in mouse models and human tissues. Human breast tumors showed a ∼7-fold elevation in kindlin-3 mRNA compared to non-neoplastic tissue by quantitative polymerize chain reaction. At the protein level, Kindlin-3 was found to be expressed abundantly in breast cancer tissue, and its expression increases with the advancing stage of tumor development. Mining of the Oncomine database (www.oncomine.com) confirmed this association: Kindlin-3 was in the top 3 % of gene products elevated in breast cancer (p&amp;lt; 10-12). When Kindlin-3 was over-expressed in a breast cancer cell line, primary tumor growth and lung metastasis increased by 2.5- and 3-fold, respectively when implanted into mice compared to cells expressing vector alone. Mechanistically, the Kindlin-cells displayed a 2.2-fold increase in Vascular Endothelial Growth Factor (VEGF) secretion and B1 integrin activation. Increased VEGF secretion resulted from enhanced production of Twist, a transcription factor which promotes tumor angiogenesis. Knockdown of Twist diminished VEGF production and knockdown of B1 integrins diminished Twist and VEGF production by Kindlin-3 cells while non-targeting si-RNA had no effect on expression of these gene products. The activation of this signaling cascade resulted in the enhancement of breast cancer cell invasion, and tumor angiogenesis and metastasis. Hence, our studies established the pathway in which cross-talk between Kindlin-3 and B1 integrins activates the nuclear translocation of TWIST, which leads to enhanced VEGF-A production and secretion, macrophage infiltration as well as activation of the Epithelial-to-mesenchymal-transition (EMT) program. The activation of this signaling cascade culminates in enhanced breast cancer cell migration, invasion and tumor angiogenesis, all of which are required for tumor progression and metastasis. In summary, by analysis of human tissue samples and in vitro and in vivo studies, we have identified a novel role for Kindlin-3 in the progression of breast cancer. To our knowledge, this is the first demonstration of the presence and implication of Kindlin-3 in breast cancer or any cancer. Citation Format: Khalid Sossey-Alaoui, Elzbieta Pluskota, Gangarao Davuluri, Katarzyna Bialkowska, Mitali Das, Daniel Lindner, Edward F. Plow. Kindlin-3 enhances breast cancer metastasis through upregulation of Twist-mediated tumor angiogenesis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2088. doi:10.1158/1538-7445.AM2014-2088
A CASE OF ABDOMINAL HYSTERECTOMY FOR RETROPERITONEAL CERVICAL FIBROID: (WEIGHING 131/2 POUNDS)
Authors: A. H. N. Lewers
Journal: BMJ (1903)

economic and other reasons stand in the way of relieving them from the non-professional work of prisons, which leaves them very little time to devote to such important inquiries.In these days of rapid communication between all parts of the world, it is, perhaps, unnecessary to emphasize the risks that are run of the introduction of tropical affections into temperate -climates, and to the desirability of studying and preventing them.
REAL WORLD TARGET VESSEL REVASCULARIZATION IN BOTH ON- AND OFF-LABEL USE OF SIROLIMUS ELUTING STENTS AT 2 YEAR FOLLOW-UP: IMPACT OF LATE EVENTS
Authors: Marvin Eng, Paul Hudson, Sarah Endemann, Colin Barker, Marcus Williams, Justin Levisay, Curtiss Stiniss, Paul Teirstein, Matthew J. Price
Journal: Journal of the American College of Cardiology (2011)
State of the art lecture: EUS and EBUS in pulmonary medicine
Authors: J. Annema, K. Rabe
Journal: Endoscopy (2006)

The development of linear echo-endoscopes has opened up fascinating new diagnostic possibilities for patients with various lung diseases. Transoesophageal ultrasound-guided fine needle aspiration (EUS-FNA) and transbronchial ultrasound-guided needle aspiration (EBUS-TBNA) are both minimally invasive diagnostic techniques that enable real-time controlled aspirations of mediastinal lymph nodes and centrally located lung tumours. By demonstrating mediastinal metastases, surgical procedures can frequently be avoided. In this short survey, we provide an overview concerning results obtained by EUS and EBUS in pulmonary medicine and discuss how these novel methods can be used in clinical practise.
Who Cares for the Epileptic?
Authors: William G. Lennox, Merle McBride, Gertrude Potter
Journal: New England Journal of Medicine (1948)

EPILEPSY is a larger public-health problem than is generally realized, even by doctors. Its supposed infrequence is due to the practice of concealment and to the widespread popular belief that for epilepsy there is no effective treatment. The United States Selective Service figures of 1917 gave for Massachusetts an incidence of 0.59 per cent (as compared with 0.515 for the whole country). Yet medical officers know that thousands of epileptic patients were not detected by the Selective Service examinations; thousands risked a lie to risk a life for their country (and the esteem of their fellows). If the statistics are . . .
Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction
Authors: Hilde Laeremans, Tilman M. Hackeng, Marc A.M.J. van Zandvoort, Victor L.J.L. Thijssen, Ben J.A. Janssen, Harry C.J. Ottenheijm, Jos F.M. Smits, W. Matthijs Blankesteijn
Journal: Circulation (2011)

The molecular pathways that control the wound healing after myocardial infarction (MI) are not completely elucidated. One of these pathways is the Wnt/Frizzled pathway. In this study, we evaluated Frizzled as a novel therapeutic target for MI. These Frizzled proteins act as receptors for Wnt proteins and were previously shown to be expressed in the healing infarct.Wnt/Frizzled signaling has been studied for decades, but synthetic ligands that interfere with the interaction between Wnts and Frizzled have not been described to date. Here we report the selection of 3 peptides derived from regions of high homology between Wnt3a and Wnt5a that act as antagonists for Frizzled proteins. UM206, the peptide with the highest affinity, antagonized the effect of Wnt3a and Wnt5a in different in vitro assays. Administration of UM206 to mice for 5 weeks, starting immediately after the induction of MI, reduced infarct expansion and increased the numbers of capillaries and myofibroblasts in the infarct area. Moreover, heart failure development was inhibited by this therapy.Blocking of Frizzled signaling reduces infarct expansion and preserves cardiac function after MI. Our findings underscore the potential of Frizzled receptors as a target for pharmacotherapy of cardiac remodeling after MI.
Of swords, ploughshares, and climate change
Authors: Tony Delamothe
Journal: BMJ (2011)

If the UK military wants to save the world it could start a little closer to home

The BMJ , with the UK Climate and Health Council and senior UK military figures, had planned to hold a conference on climate change this month. The editorial announcing the conference (now rescheduled for 17 October) made a convincing case for collaboration between the medical and military professions: “Climate change poses an immediate and grave threat, driving ill health and increasing the risk of conflict, such that each feeds off the other” ( BMJ 2011;342:d1819, doi:10.1136/bmj.d1819).

So far, so good, though the solutions the editorialists identify—shifting to renewable energy sources, reducing energy consumption, and improving the infrastructure of cities—don’t look like happening any time soon. Meanwhile, could senior military figures begin agitating for change closer to home?

They could start with Africa, which in 2010 received overseas development aid worth $29.3bn (£18.2bn; €20.1bn), according to Organisation for Economic Co-operation and Development figures (www.oecd.org/document/35/0,3746,en\_2649\_34447\_47515235\_1\_1\_1_1,00.html). Nevertheless the Stockholm International Peace Research Institute estimates that the continent’s total military spending was $30.1bn last year. It is hard to escape the image of all of Africa’s aid …
Echocardiographic Studies to Explain Mitral-Valve-Opening Snaps from Nonstenotic Mitral Valves.
Authors: David K. Millward
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Echocardiographic Studies to Explain Mitral-Valve-Opening Snaps from Nonstenotic Mitral Valves.David K. Millward, M.D., Ernest Craige, M.D.David K. Millward, M.D.Search for more papers by this author, Ernest Craige, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-867_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn opening snap is thought to be diagnostic of either mitral or tricuspid valve stenosis. A study using the simultaneous graphic recording of mitral valve motion by echocardiography along with the phonocardiogram and the left ventricular apex cardiogram has led to the identification of a mitral-valve-opening snap in each of the following cardiac conditions: [1] tricuspid atresia with a large atrial septal defect; [2] idiopathic second- and third-degree heart block; [3] ventricular septal defect; [4] mitral regurgitation; and [5] thyrotoxicosis. In each condition the opening snap occurred 90 to 110 msec after A2on the phonocardiogram and was found to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chapel Hill, N.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 867-867KeywordsAtrial septal defectEchocardiographyHeartLongitudinal studiesMitral insufficiencyStenosisVentricular septal defects Issue Published: 1 May 1972 PDF DownloadLoading ...