tbuckley/cabot-search huggingface dataset:
Postischemic Stunning Can Affect Left Ventricular Ejection Fraction and Regional Wall Motion on Post-Stress Gated Sestamibi Tomograms
Authors: Lynne L Johnson, Stephen A Verdesca, Wady Y Aude, Rita C Xavier, Lorraine T Nott, Michael W Campanella, Guido Germano
Journal: Journal of the American College of Cardiology (1997)
The specificity of JAK3 kinase inhibitors
Authors: Paul S. Changelian, Deborah Moshinsky, Cyrille F. Kuhn, Mark E. Flanagan, Michael J. Munchhof, Thomas M. Harris, David A. Whipple, Jonathan L. Doty, Jianmin Sun, Craig R. Kent, Kelly S. Magnuson, David G. Perregaux, Perry S. Sawyer, Elizabeth M. Kudlacz
Journal: Blood (2007)
Gastro-gastric Intussusception Produced by Pedunculated Intragastric Tumour
Authors: A. Thomson
Journal: BMJ (1950)

Enteric Intussusception Presenting as a Cystic Abdominal TumourThe protean manifestations of acute abdominal emergencies are only too well known to the surgeon, and the following case is recorded not merely to demonstrate unusual clinical findings in such a condition but to show how one can be misled in their interpretation.The rarities in medicine are sometimes self-evident if one is acquainted with the condi- tion, but the mistakes in the diagnosis of the commonplace are often due to a wrong interpretation of the clinical findings, even after a careful examination.
Lysozyme and Calcium
Authors: ROBERT A. GREENWALD
Journal: Annals of Internal Medicine (1976)

Comments and Correction1 August 1976Lysozyme and CalciumROBERT A. GREENWALD, M.D.ROBERT A. GREENWALD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-2-261_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Goldstein and colleagues (Ann Intern Med 84:445-446, 1976) have shown elevated lysozyme levels in sera from patients with hypercalcemia due to either hyperparathyroidism or malignancy, and they have interpreted their data in terms of the calcium-induced release of lysozyme from polymorphonuclear leukocytes (1). In the absence of direct measurements of intracellular, or releasable lysozyme levels, or both in polymorphonuclear leukocytes from the affected patients, this conclusion is premature, and an alternative explanation of their findings should be considered.Lysozyme is a prominent component of many connective tissues, including bone (seeReference 2 for a detailed review), and...References1. GOLDSTEINHORNKAPLAN IJH: Calcium-induced lysozyme secretion from human polymorphonuclear leukocytes. Biochem Biophys Res Commun 60:807-812, 1974 CrossrefMedlineGoogle Scholar2. GREENWALD R: Connective tissue lysozyme in health and disease. Semin Arthritis Rheum, in press Google Scholar3. WOLINSKYCOHN ID: Bone lysozyme: partial purification, properties, and depression of activity by parathyroid extract. Nature 210:413-414, 1966 CrossrefMedlineGoogle Scholar4. KUETTNERGUENTHERRAY KHR: Lysozyme in preosseous cartilage. Calcif Tissue Res 1:298-305, 1968 CrossrefMedlineGoogle Scholar5. EISENSTEINSORGENTEARSENIS RNC: Vitamin D effects on tissue and serum lysozyme. Arch Pathol 94:479-485, 1972 MedlineGoogle Scholar6. HOWELLPITASORGENTE DJN: Possible role of lysozyme in degradation of osteoarthritic cartilage. Trans Assoc Am Physicians 87:169-179, 1974 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLysozyme levels in tissues of iron-deficient ratsLysozyme and HypercalcaemiaP. J. PHILLIPS, R. W. PAIN, J. LLOYD 1 August 1976Volume 85, Issue 2Page: 261-261KeywordsBoneCalciumHypercalcemiaHyperparathyroidismLysozymeNeutrophils Issue Published: 1 August 1976 PDF DownloadLoading ...
Work-Related Carpal Tunnel Syndrome
Authors: Peter A. Nathan
Journal: JAMA (1990)

To the Editor.—  The article entitled Occupational Disease Surveillance: Carpal Tunnel Syndrome 1 presents a three-part surveillance case definition for work-related carpal tunnel syndrome (CTS). The article suggests that occupational hand activities are a significant risk factor for CTS.  According to the article, 47% of CTS cases reported in Santa Clara County, California, in 1987 were believed, by the responding providers, to be work related. This means that the majority, or 53%, were not believed to be work related. No surveillance case definition was presented to help the reader understand why the latter cases fell outside the work-related CTS category. In the absence of this information, the reader might assume that the mere performance of certain types of occupational hand activities equates with work-related CTS.  Carpal tunnel syndrome is a widely prevalent condition, and a surveillance study of any segment of the adult population will likely yield the finding of
Career problems of women doctors.
Authors: R Henryk-Gutt, R Silverstone
Journal: BMJ (1976)

Information was received from 61 women doctors who were having difficulty continuing with medical careers. Two main problems were disclosed. Firstly, despite the special arrangements made for women doctors, it is difficult to obtain postgraduate training. The provision of supernumerary posts does not seem to offer a satisfactory solution. Secondly, doctors who have completed postgraduate training but cannot yet return to full-time work are unable to obtain posts at an appropriate level. Both of these problems stem primarily from the need for part-time work by the mothers of young children. Most of the doctors wish to return to full-time or nearly full-time work when family responsibilities are fewer. In view of the increasing proportion of women doctors it seems important that large numbers are not unnecessarily lost from professional work. Some possible approaches to solving the problems are suggested.
Abstract 4637: Intra-individual changes in circulating IGF-1 and IGF-1/IGFBP-3 molar ratio are associated with colorectal adenomatous polyps presence
Authors: Adelheid Soubry, Rebecca Sedjo, Frances Wang, Tim Byers, Clifford Rosen, Anatoli Yashin, Svetlana Ukraintseva, Steve Haffner, Ralph D'Agostino, Dora Il'yasova
Journal: Cancer Research (2011)

Abstract Background: High levels of circulating insulin-like growth factor-1 (IGF-1) have been associated with increased risks of several cancers, including colorectal cancer. Methods: In a sub-cohort of the Insulin Resistance and Atherosclerosis Study (IRAS), we examined the associations between circulating IGF-1 and IGF-1/IGFBP-3 molar ratios, as well as their change patterns during 10-year follow-up, with the presence of colorectal adenomatous polyps at the end of the follow-up. Results: The general trend was decrease of both variables with age. Based on this trend, two patterns were considered: “no increase” (variation within 15% of baseline and/or decrease) and “ever increase” (at least one increase of &amp;gt; 15%). In the subgroup of participants with normal glucose tolerance, “ever increase” was positively associated with colorectal adenoma: ORs were 3.65 (1.30-10.8) and 2.83 (1.00-8.22) for IGF-1 and IGF-1/IGFBP-3, respectively. No association was found between actual levels of IGF-1 or IGF-1/IGFBP-3 at any time point and the presence of colorectal adenoma. Conclusion: Our data suggest that increase in circulating IGF-1 and IGF-1/IGFBP-3 may represent an unnatural trend of a disturbed signaling pathway, which could favor the development of precancerous lesions, such as colorectal adenoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4637. doi:10.1158/1538-7445.AM2011-4637
1158 Long term treatment with adefovir dipivoxil (ADV) for three years in patients with lamivudine-resistant (LAM-R) HBV and HIV co-infection results in significant and sustained clinical improvement
Authors: Y BENHAMOU, V THIBAULT, P VIG, M VALANTIN, P GUYON, C KATLAMA, B LU, G CURRIE, C BROSGART, T POYNARD
Journal: Hepatology (2003)

The development of antiviral-resistant mutations with long-term treatment remains a major concern in the treatment of chronic hepatitis B virus (HBV) infection. The study aimed to compare the therapeutic efficacy of entecavir 1 mg versus combined lamivudine/adefovir dipivoxil (Lam/Adv) in chronic HBV patients resistant to lamivudine monotherapy.This study included two groups of lamivudine-resistant patients who received lamivudine 100 mg for 1–3 years. Group 1 was composed of 25 cases (52% HBeAg+ve) who received combined Lam/Adv, and group 2 was composed of 13 patients (30.8% HBeAg+ve) who received entecavir 1 mg. Pre-enrolment assessment included biochemical, serological and quantitative HBV-DNA testing as well as HBeAg and hepatitis B envelope antibody (HBeAb) assessment. Evaluation was done at 3, 6, 12, 24 and 36 months of treatment by the same parameters. Hepatitis B surface antigen and antibody (HbsAg and HBsAb) were assessed after each year of treatment.At the end of 36 months of treatment, 16 cases (69%) in group 1 completed the study period, versus 13 (100%) in group 2. Two cases in group 1 underwent HBeAg seroconversion, accompanied by HBV-DNA undetectability, at 6 and 12 months, respectively; no cases were seroconverted in group 2. Both treatments achieved improvement in alanine aminotransferase (ALT), bilirubin and alpha-foetoprotein equally at the end of the study. HBV-DNA undetectability was better achieved in group 2 when compared to group 1. HBeAg seroconversion was only achieved in two cases in group 1, whereas no cases lost HBeAg in group 2. None of our cases achieved HbsAg seroconversion or loss at the end of the study period.The entecavir 1-mg monotherapy group achieved better HBV-DNA undetectability starting at 3 months of treatment when compared to the Lam/Adv group; however, both lines of treatment showed almost similar results over the rest of the study period. HBeAg seroconversion was only achieved in two cases in the combined Lam/Adv group, whereas no cases lost HBeAg in the other group.
How to Obtain a National Heart, Lung, and Blood Institute-Sponsored K08 and K99/R00 Grant in the Current Funding Climate
Authors: Steven R. Houser
Journal: Circulation Research (2012)

1 Cardiovascular disease is still the number 1 cause of death in the United States. 2 There is an obvious need to develop novel therapies to prevent or reverse the consequences of these diseases.New therapies should reduce the morbidity and mortality of cardiovascular disease, lower associated costs of health care, and improve the lives and productivity of affected patients.Basic, translational, and clinical research is the foundation on which these new therapies will be developed.High-impact discoveries that lead to medical advances are usually made by well-trained biomedical scientists, and many of these investigators have started their careers with support from NHLBI K08 (Mentored Clinical Scientist) and K99/R00 (Pathway to Independence) awards.These grants support training of young scientists in premier laboratories to prepare them for careers in what has been, in my view, the best biomedical science environment in the world, the United States.This "pipeline" of young talent is challenged by the current funding environment.In my view,
Benefits of a programme taking advantage of patient-instructors to teach and assess musculoskeletal skills in medical students
Authors: M Bideau, P-A Guerne, M-P Bianchi, P Huber
Journal: Annals of the Rheumatic Diseases (2006)

<b>Aim:</b> To evaluate a rheumatoid arthritis patient-instructor-based formation–assessment programme for its ability to improve and assess musculoskeletal knowledge and skills in third-year medical students. <b>Methods:</b> (1) The quality of our musculoskeletal teaching was assessed before patient-instructor intervention through an open-questions test (pre-test) and performance record forms (PRFs) filled in by the patient-instructors. (2) The improvement afforded by patient-instructors was evaluated through a second (identical) open-questions test (post-test). (3) The resulting skills in the students were further assessed by an individual patient-instructors physical status record form (PSRF), filled in by the students. <b>Results:</b> Pre-tests and post-tests showed an improvement in correct answers from a mean score of 39% to 47%. The history-taking questions that obtained &lt;50% scores in the pre-test mostly dealt with the consequences of a chronic illness. Intervention of patient-instructors especially improved knowledge of the psychosocial aspects and side effects of drugs. With regard to physical examination, patient-instructors makedly improved the identification of assessment of signs of active and chronic inflammation. PRF analysis showed that 10 of 28 questions answered by &lt;50% of the students were related to disease characteristics of rheumatoid arthritis, extra-articular signs, side effects of drugs and psychosocial aspects. Analysis of the PSRF indicated that the weakness of our students' physical examination abilities in particular is related to recognising the types of swelling and differentiating tenderness from pain on motion<i>.</i> <b>Conclusion:</b> This study proves the considerable benefits of the involvement of patient-instructors in the teaching and assessment of clinical skills in students.
Nuclear Receptor Expression Defines a Set of Prognostic Biomarkers for Lung Cancer
Authors: Yangsik Jeong, Yang Xie, Guanghua Xiao, Carmen Behrens, Luc Girard, Ignacio I. Wistuba, John D. Minna, David J. Mangelsdorf
Journal: PLoS Medicine (2010)

David Mangelsdorf and colleagues show that nuclear receptor expression is strongly associated with clinical outcomes of lung cancer patients, and this expression profile is a potential prognostic signature for lung cancer patient survival time, particularly for individuals with early stage disease.
THE RELATIVE INDICATIONS FOR ENUCLEATION AND THE MULES OPERATION.
Authors: N. J. HEPBURN
Journal: JAMA (1902)

The removal of an eye is a subject of grave consideration in the mind of the patient as well as the physician. It ranks in the lay mind with the major operations, such as the removal of a limb, not only as a matter of sentiment, but even in the scale of damages allowed by the accident insurance corporations and by the courts in suits for payment of damages. The loss of visual range over an arc of approximately 60 degrees, and the resulting deformity, often sufficiently apparent to seriously impede the earning capacity, are also factors in the production of the unwillingness on the part of the patient to submit to the operation, and must be met by cogent and convincing reasons on the part of the medical attendant. If the promise can be given of a minimum of apparent defect, with a maximum of safety or benefit in
Human hematopoietic stem cell adherence to cytokines and matrix molecules.
Authors: M W Long, R Briddell, A W Walter, E Bruno, R Hoffman
Journal: Journal of Clinical Investigation (1992)

The hematopoietic microenvironment is a complex structure in which stem cells, progenitor cells, stromal cells, growth factors, and extracellular matrix (ECM) molecules each interact to direct the coordinate regulation of blood cell development. While much is known concerning the individual components of this microenvironment, little is understood of the interactions among these various components or, in particular, the nature of those interactions responsible for the regional localization of specific developmental signals. We hypothesized that cytokines act together with ECM molecules to anchor stem cells within the microenvironment, thus modulating their function. In order to analyze matrix-cytokine-stem cell interactions, we developed an ECM model system in which purified stem cell populations and plastic-immobilized individual proteins are used to assess the role of various matrix molecules and/or cytokines in human hematopoietic cell development. Analysis of these interactions revealed that a single ECM protein, thrombospondin, in conjunction with a single cytokine (e.g., c-kit ligand), constitutes a developmental signal that synergistically modulates hematopoietic stem cell function.
LONG-TERM CONTINUOUS POSITIVE AIRWAY PRESSURE DOES NOT IMPROVE BLOOD PRESSURE CONTROL IN HYPERTENSIVES WITH SLEEP APNEA: A 3-YEAR FOLLOW-UP STUDY
Authors: A. Kasiakogias, K. Tsioufis, C. Thomopoulos, D. Aragiannis, A. Kordalis, I. Andrikou, I. Bafakis, K. Kintis, P. Hatziyiannis, D. Tousoulis, C. Stefanadis
Journal: Journal of the American College of Cardiology (2012)
Diet and heart: a postscript.
Authors: J N Morris, J W Marr, D G Clayton
Journal: BMJ (1977)

During 1956-66, 337 healthy middle-aged men in London and south-east England participated in a seven-day individual weighed dietary survey. By the end of 1976, 45 of them had developed clinical coronary heart disease (CHD) which showed two main relationships with diet. Men with a high energy intake had a lower rate of disease than the rest, and, independently of this, so did men with a high intake of dietary fibre from cereals. Energy intake reflects physical activity, but the advantage of a diet high in cereal fibre cannot be explained; there was no evidence that the disease was associated with consumption of refined carbohydrates. Fewer cases of CHD developed among men with a relatively high ratio of polyunsaturated to saturated fatty acids in their diet, but the difference was not statistically significant.
Cutaneous Rhizopus Infection: R rhizopodiformis vs R oryzae-Reply
Authors: William Beaumont
Journal: JAMA (1980)

<h3>In Reply.—</h3> I regret that the original culture material is no longer available, and I appreciate the need for epidemiologic surveys of this unfortunate cutaneous infection. The statement that the only confirmed culture yields associated with the Elastoplast bandages have identified<i>R rhizopodiformis</i>and not R oryzae is a difficult conclusion for me to accept. The report by Keys et al, "Nosocomial Outbreak of<i>Rhizopus</i>Infections Associated With Elastoplast Wound Dressings—Minnesota" (<i>Morbidity Mortality Weekly Rep</i>27:33-34, 1978), describes six patients who had<i>R oryzae</i>infections associated with Elastoplast adhesive dressings.
Trends in Cardiovascular Medicine
Authors: Prediman Krishan Shah
Journal: JAMA (1992)

<i>Trends in Cardiovascular Medicine</i>publishes concise reports on recent developments across a broad range of cardiovascular research. "Emerging Techniques"—a regular feature—focuses on new diagnostic tools and potential clinical applications. In the journal's first issue, this section contained provocative articles on the role of the polymerase chain reaction for cardiovascular diagnoses and on the feasibility, safety, and utility of percutaneous coronary angioscopy. A "Brief Reviews" section offers short (six-page) articles covering such diverse topics as cell proliferation in atherosclerosis, lipid abnormalities in myocardial cell injury, and the use of molecular mutants and biochemical conjugates in thrombolytic therapy. "Gene Transfer and Cardiovascular Disease" by Elizabeth G. Nabel and Gary J. Nabel is the sort of clearly written distillation of scientific research more often found in the pages of<i>Science</i>or<i>Nature</i>than in a specialized medical journal. (Indeed, two earlier reports on this subject by the same authors did appear in<i>Science</i>
“Normal” is not the issue: It is “effective” goal attainment that counts
Authors: J. H. Carr, R. B. Shepherd
Journal: Behavioral and Brain Sciences (1996)

Abstract Adaptive motor patterns that emerge after a neuromusculoskeletal lesion reflect not only the primary lesion, but also the dynamic characteristics of the musculoskeletal linkage and environment in which the action is performed. Although these patterns may be optimal, they may also be ineffective as goal-directed actions; effectiveness may only be regained if training addresses primary deficits and ensures practice without gross biomechanical adaptations.
Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial
Authors: Rachel K Morris, Gemma L Malin, Elisabeth Quinlan-Jones, Lee J Middleton, Karla Hemming, Danielle Burke, Jane P Daniels, Khalid S Khan, Jon Deeks, Mark D Kilby
Journal: The Lancet (2013)
Professor Sir Gordon Robson, CBE, President of the Royal Society of Medicine, 1986-1988
Authors: Christopher Paine
Journal: Journal of the Royal Society of Medicine (2007)

Professor Sir Gordon Robson died on 23 February 2007 aged 85. As President of the RSM, he did much to help Dr Carice Ellison and her late husband Dr Percy Cliffe establish their annual Lecture, the first being given during his term. He also encouraged the setting up of the now thriving Section of Clinical, Forensic and Legal Medicine.​Medicine.



Figure 1





He was born in Stirling, and did his medical training in Glasgow. After qualifying in 1944, he was abruptly thrown into the realities of home deliveries in poor households where expensive medical help was often sought too late: this experience ignited his lifelong determination to improve standards of practice. He then joined the RAMC and became a trainee anaesthetist to East Africa Command in Nairobi, where his skills were quickly appreciated by the Army surgeons.

After the war he worked in Glasgow, Newcastle and Edinburgh, and then for eight years as the Wellcome Professor of Anaesthetics at McGill University, Montreal. In 1964, he returned as the first Professor and Chairman of the Department of Anaesthetics at the Royal Postgraduate Medical School and Hammersmith Hospital. During his 22-year tenure the standing of the department and its research had the highest acclaim.

Sir Gordon did much on the national scene to improve standards of anaesthesia and patient care. He took an active part in the Faculty of Anaesthetists and was later its Dean. He introduced the inspection of anaesthetics departments for training purposes—having the temerity to remove trainees from a number of well-known departments in London where insufficient supervision was taking place, often because senior staff were absent. In 1979 he led invaluable work on the definition of brain death, which is so important in transplant surgery. The criteria he developed are still used worldwide and almost unaltered today. This work, and his other research interests, led to his long contribution to the RNLI, as Chairman of its Medical and Survival Committee and a Life Vice-President.

In 1984 he became the last doctor to be Chairman of the Advisory Committee on Distinction Awards. He ran this system with scrupulous fairness and care for nine years—the longest since Lord Moran. Very seldom were his judgements—always formed through carefully sought professional opinion and based on strict, if unpublished, criteria—proved wrong.

Gordon Robson received many medical honours, and was the first Anaesthetist to be Vice-President of the Royal College of Surgeons of England. He was appointed CBE in 1977 and was knighted in 1982. He married his first wife, Dr Martha Kennedy, in 1945. She had a successful medical career, moving workplace with him. She died in 1975. Gordon had a long final illness which he bore with great courage. He used his own expertise to look after himself, and in this was given calm and invaluable support by his second wife, Jenny Kilpatrick, whom he had married in 1984.