tbuckley/cabot-search huggingface dataset:
Abstract A8: Network analysis of retroviral and transposon mutagenesis sites in B cell lymphoma converges on MyD88 pathway
Authors: Samuel Lifton, Alicia Olivier, Adam Dupuy, Wendy Dubois, Linda Wolff, Siegfried Janz
Journal: Cancer Research (2012)

Abstract Using the murine leukemia virus (MuLV) and the Sleeping Beauty retrotransposon, we have generated several thousand mutagenesis sites associated with development of B cell lymphoma in iMyc mice. We have utilized the gene-centric common insertion site algorithm (gCIS) to determine common events in B cell lymphomagenesis. After gCIS analysis, we have established networks based on filtering with known protein-protein and transcription factor-transcription factor interaction networks. Additionally, gene set enrichment analysis was performed subtracting T cell lymphoma-associated pathways from B cell lymphoma-associated pathways. Several promising networks have been identified through these methods, including one leading to the activation of MyD88. MyD88 mutations are recently identified in several B cell lymphomas. These findings demonstrate the utility of these methods and suggest that common insertion sites during mutagenesis can either affect a single important factor, or converge on its interaction partners. Citation Format: Samuel Lifton, Alicia Olivier, Adam Dupuy, Wendy Dubois, Linda Wolff, Siegfried Janz. Network analysis of retroviral and transposon mutagenesis sites in B cell lymphoma converges on MyD88 pathway [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr A8.
Flupheazine enenthate and schizophrenia.
Authors: M. Valentine, H. Trueman
Journal: BMJ (1968)

the press, the journals, and the vaccine manufacturers with the approach of the Hong Kong strain to inoculate high-risk groups, institutions, etc.I am now in my eleventh year of egg albumen sensitivity following that inoculation.Coping with an egg allergy is a perpetual problem, and eggless cookery is a trial for any wife.The new Hong Kong vaccine is also grown on eggs.-Iam, etc.,
Car users in Wales are being urged not to smoke in vehicles carrying children
Authors: R. Dobson
Journal: BMJ (2012)

The Welsh Assembly has this week launched a campaign, “Fresh start Wales,” designed to protect children from the harmful effects of secondhand smoke.

The first minister of Wales, Carwyn Jones, says that the Welsh government will consider pursuing a ban on smoking in cars carrying children if exposure to secondhand smoke in cars does not start to fall within the next three years. A survey of health behaviour in schoolchildren indicated that around 20% of 11-16 year …
Complications of coronary arteriography from the Collaborative Study of Coronary Artery Surgery (CASS).
Authors: K Davis, J W Kennedy, H G Kemp, M P Judkins, A J Gosselin, T Killip
Journal: Circulation (1979)

Data were collected prospectively on 7553 consecutive patients undergoing coronary arteriography. The studies were performed at 13 clinics of the Collaborative Study of Coronary Artery Surgery (CASS) using brachial and femoral techniques. There were eight deaths 0--24 hours and seven deaths 24--48 hours after arteriography (2/1000). There were 15 non-fatal myocardial infarctions (MIs) 0--24 hours and four MIs 24--48 hours after arteriography (2.5/1000). Of 657 cases with left main stenosis greater than or equal to 50%, five died and three had MI. Left main disease increased risk of death by 6.8 times (p less than 0.001). Other factors increasing risk were unstable angina, congestive heart failure, multiple premature ventricular contractions, and hypertension. Of the 1187 patients studied from the brachial artery, six died (0.51%) and five had MIs (0.42%). In 6328 patients studied from the femoral artery, nine died (0.14%) and 14 had MIs (0.22%). The brachial artery technique increased the risk of death 3.6 times compared with the femoral approach (p less than 0.05). This result did not apply when analysis was restricted to laboratories with 80% or more brachial procedures. Risk was not altered by heparin. Thus, a prospective, multicenter analysis of complications reveals low risk of coronary arteriography but significant difference between two techniques.
Understanding controlled trials: What outcomes should be measured?
Authors: M. Roland, D. Torgerson
Journal: BMJ (1998)

Many types of clinical, patient related, and economic outcomes can be measured in trials. The choice of one or more outcomes will depend on the nature of the study and the question it is trying to answer. Objectives can relate to different levels of observation and analysis,from the individual to the family, the community, and society as a whole.

If a trial is “explanatory”1then a single main measure of clinical outcome may be appropriate. For example, if a trial is designed to determine which of two antihypertensive agents is more effective at lowering blood pressure then hypertensive control will be the main outcome. Traditionally, clinical trials have used physiological or biomedical outcomes, but these may not be well related …
Tissue Doppler-derived myocardial acceleration for evaluation of left ventricular diastolic function
Authors: Ikuo Hashimoto, Aarti Hejmadi Bhat, Xiaokui Li, Michael Jones, Crispin H. Davies, Julia C. Swanson, Sebastian T. Schindera, David J. Sahn
Journal: Journal of the American College of Cardiology (2004)
Cancer of the gastrointestinal tract. Radiation therapy
Authors: M. A. Holbrook
Journal: JAMA (1974)

RADIATION therapy has played little part in the therapeutic managerment of patients with gastric adenocarcinoma. In a retrospective study, we found no difference in survival between a group of 24 patients with localized but unresectable gastric carcinoma treated with radiation therapy and 43 patients with similar disease who received no specific treatment.<sup>20</sup> However, there are reports that chemotherapy with fluorouracil given in conjunction with radiation therapy has produced encouraging results.<sup>21,22</sup> We performed a randomized double-blind study of patients who had locally unresectable gastric adenocarcinoma and in whom all known disease could be encompassed by conventional radiation therapy fields.<sup>21</sup>All patients received radiation therapy at the rate of 900 rads to 1,200 rads per week to a total dose of 3,500 rads to 4,000 rads. By random selection, half of the patients received fluorouracil at a daily dosage of 15 mg/kg of body weight until a total dose
The Ethical “Elephant” in the Death Penalty “Room”
Authors: Michael Keane
Journal: The American Journal of Bioethics (2008)

The United States Supreme Court recently ruled that execution by a commonly used protocol of drug administration does not represent cruel or unusual punishment. Various medical journals have editorialized on this drug protocol, the death penalty in general and the role that physicians play. Many physicians, and societies of physicians, express the opinion that it is unethical for doctors to participate in executions. This Target Article explores the harm that occurs to murder victims' relatives when an execution is delayed or indefinitely postponed. By using established principles in psychiatry and the science of the brain, it is shown that victims' relatives can suffer brain damage when justice is not done. Conversely, adequate justice can reverse some of those changes in the brain. Thus, physician opposition to capital punishment may be contributing to significant harm. In this context, the ethics of physician involvement in lethal injection is complex.
CASE OF CAROTINEMIA
Authors: F. W. Niehaus
Journal: JAMA (1924)

Mrs. H. H., aged 25, a housewife, entered University Hospital, June 9, 1923, complaining of weakness, thirst and marked appetite. The trouble began two years before, two months preceding the birth of her baby. The urine at that time showed a marked amount of sugar. On a moderately restricted carbohydrate diet, the patient remained sugar free until December, 1922, when she again showed sugar, and all the previous symptoms recurred, much aggravated. In two months she had lost 40 pounds (18 kg.). A physician prescribed a vegetable diet containing a high carrot content. About a month later her hands became yellow, which color was present when she entered the hospital. The patient was markedly undernourished. There was a distinct yellow discoloration of the hands, feet and nasolabial folds. There was no pigmentation of the sclerae. At the University Hospital she was taken off the restricted diet and was given insulin
How Much Are We Willing To Pay for Information about Quality
Authors: Lisa I. Iezzoni
Journal: Annals of Internal Medicine (1997)

Letters1 May 1997How Much Are We Willing To Pay for Information about QualityLisa I. Iezzoni, MD, MScLisa I. Iezzoni, MD, MScBeth Israel Deaconess Medical Center, Boston, MA 02215Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-9-199705010-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The Annals published the uncorrected version of my editorial [1], written to accompany the paper by Pine and colleagues [2]. Annals copyeditors had made changes to a key sentence of my editorial that obscured my central concern about the claims of Pine and colleagues. I corrected this and other minor errors when reviewing the galley proofs, but unfortunately the uncorrected version went to press. This letter correctly states the message of my original manuscript.In the fourth paragraph of my editorial, I noted that Pine and colleagues suggested that linking existing electronic data from laboratory reporting systems ...References1. Iezzoni LI. How much are we willing to pay for information about health care quality? [Editorial] Ann Intern Med. 1997; 126:391-3. Google Scholar2. Pine M, Norusis M, Jones B, Rosenthal GE. Predictions of hospital mortality rates: a comparison of data sources. Ann Intern Med. 1997; 126:347-54. Google Scholar Author, Article, and Disclosure InformationAuthors: Lisa I. Iezzoni, MD, MScAffiliations: Beth Israel Deaconess Medical Center, Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMaximising the value of hospital administrative datasets 1 May 1997Volume 126, Issue 9Page: 746KeywordsElectronic medical recordsInformation storage and retrievalInformation technologyResearch designResearch laboratories ePublished: 15 August 2000 Issue Published: 1 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Parasympathetic Nervous System and Heart Failure
Authors: Brian Olshansky, Hani N. Sabbah, Paul J. Hauptman, Wilson S. Colucci
Journal: Circulation (2008)

A bundant evidence links sympathetic nervous system activation to outcomes of patients with heart failure (HF). 1 In contrast, parasympathetic activation has complex cardiovascular effects that are only beginning to be recognized.][4][5] In the present article, we review cardiovascular responses to parasympathetic activation, address the modulating factors that can affect parasympathetic function, discuss the role of the vagus nerve in ventricular dysfunction, and consider how activation of the parasympathetic nervous system may have important therapeutic implications for patients with congestive HF. Structure of the Parasympathetic Limb of the Autonomic Nervous SystemThe parasympathetic nervous system originates from medial medullary sites (nucleus ambiguous, nucleus tractus solitarius, and dorsal motor nucleus) and is modulated by the hypothalamus.Vagal efferents extend from the medulla to postganglionic nerves that innervate the atria via ganglia located in cardiac fat pads with neurotransmission that is modulated via nicotinic receptors.Postganglionic parasympathetic and sympathetic cholinergic nerves then affect cardiac muscarinic receptors (the Figure ). 6 -8 Vagus nerve afferent activation, originating peripherally, can modulate efferent sympathetic and parasympathetic function centrally and at the level of the baroreceptor.Efferent vagus nerve activation can have tonic and basal effects that inhibit sympathetic activation and release of norepinephrine at the presynaptic level.Acetylcholine release from parasympathetic nerve terminals will activate ganglionic nicotinic receptors that in turn activate muscarinic receptors at the cellular level.Cardiovascular effects include heart rate reduction by inhibition of the sympathetic nervous system and by direct hyperpolarization of sinus nodal cells.Parasympathetic activation can affect atrioventricular nodal conduction mediated predominantly through the left vagus nerve.Furthermore, muscarinic receptors on blood vessel walls can cause vasorelaxation through a nitric oxide (NO)-modulated pathway but can also cause vasoconstriction by directly activating smooth muscle. 6 -8 Therefore, although the sympathetic nervous system has global effects on cardiovascular physiology in an all-or-none type of response, the parasympathetic nervous system can have selective modulation at various levels.
Self referral to accident and emergency department: patients' perceptions.
Authors: S. Singh
Journal: BMJ (1988)

A study was conducted (a) to assess the number of patients registered with a south London general practice who over 11 weeks referred themselves to an accident and emergency department, (b) to identify the characteristics of those patients, and (c) to determine their perceptions of the services and resources available within their general practices and of the role of accident and emergency departments. Two hundred and thirty four patients referred themselves to a casualty department during the study period, of whom 217 (93%) were interviewed by means of a semistructured questionnaire. Of the 217 patients interviewed, only 15 had tried to contact their general practitioner before attending the casualty department. Eighty nine patients considered that their problem was urgent and required immediate attention and many that they would need an x ray examination. A substantial minority of patients thought that their doctor would not be available. It is concluded that patients' perceptions of their problems and of access to their doctors are the main determinants of self referral to a casualty department. These findings have important implications for patient education.
Surgeons may need to work from “chambers” to meet local demand
Authors: Adrian O'Dowd
Journal: BMJ (2006)

Surgeons in England and Wales may need to work for a network rather than a specific NHS trust in the future to meet demand in their local area, says a new consultation document.

The Royal College of Surgeons of England last week published the first in a series of consultation papers on reconfiguring surgical services (emergency and elective) in England and Wales and set out several proposals.

One was that in the future consultant surgeons may need to …
Bacteria and Safety of the Blood Supply
Authors: James P. AuBuchon
Journal: Annals of Internal Medicine (1998)

Letters15 July 1998Bacteria and Safety of the Blood SupplyJames P. AuBuchon, MD, John D. Birkmeyer, MD, and Michael P. Busch, MD, PhDJames P. AuBuchon, MDDartmouth-Hitchcock Medical Center; Lebanon, NH 03756University of California, San Francisco; San Francisco, CA 94118Search for more papers by this author, John D. Birkmeyer, MDDartmouth-Hitchcock Medical Center; Lebanon, NH 03756University of California, San Francisco; San Francisco, CA 94118Search for more papers by this author, and Michael P. Busch, MD, PhDDartmouth-Hitchcock Medical Center; Lebanon, NH 03756University of California, San Francisco; San Francisco, CA 94118Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-2-199807150-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We are pleased that Drs. Kuehnert and Jarvis have used a response to our review to highlight the current nationwide study of the frequency and correlates of bacterial contamination of blood components. Clearly, more information is needed to precisely determine the risk for this occurrence and to identify possible ways to interdict contaminated units.The intent of our article was to highlight the unintended consequences of several efforts to improve the safety of the blood supply. Because these efforts have focused primarily on reducing risks for viral transmission, we did not discuss other transfusion-related complications.With the dramatic ... Author, Article, and Disclosure InformationAffiliations: Dartmouth-Hitchcock Medical Center; Lebanon, NH 03756University of California, San Francisco; San Francisco, CA 94118 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1998Volume 129, Issue 2Page: 165KeywordsBacteriaBloodSafety Issue Published: 15 July 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Reducing Rates of Diagnostic Imaging-Reply
Authors: Robert L. Bree
Journal: JAMA (1997)

<h3>In Reply.</h3> —We thank Dr Greenberg for his interest in our article. Dr Greenberg suggests that 1 reason there was no difference in utilization between the 2 internal medicine services studied was that the physicians were knowledgeable on the subject of appropriateness of radiology testing. We, however, speculated that the complexity of inpatient problems leads to significant clinical uncertainty. That, combined with the need to decrease inpatient length of stay, makes inpatient utilization management difficult and outpatient utilization management more attractive. Dr Greenberg raises concerns that we used the example of in-office self-referral as an area in which utilization management has been successful in the outpatient setting; however, we failed to cite published research that refutes the argument. The article by Hillman et al<sup>1</sup>cited in our article and a subsequent article by Hillman et al<sup>2</sup>clearly show that nonradiologists who own radiology equipment order more tests than nonradiologists who
A FEW CONSIDERATIONS REGARDING CLIMATIC CHANGE AND SERUM THERAPHY IN PULMONARY TUBERCULOSIS.
Authors: S. G. BONNEY
Journal: JAMA (1898)

If an apology is necessary for the introduction of that concerning which so much has already been written, it is found in the vast importance of the subject, the wide diversity of opinions, the rather general absence of clearly defined knowledge and the increasing mass of literature extolling without limit the virtues of special methods of treatment. It is not my purpose to advocate unduly the adaptability of any climate or climates to the various stages of the disease. To present a plea for the more rational and conservative measures of treatment in a climate appropriate to the individual case, in opposition to the present employment of serum-therapy in its various modifications, is the object of this paper. As a preliminary postulate, I will submit that climate in conjunction with painstaking attention to details of management offers to the pulmonary invalid greater assurance of improvement than can be otherwise obtained.
Arthritogenic potential of the 65 kDa stress protein--an experimental model.
Authors: V R Winrow, S Ragno, C J Morris, M J Colston, P Mascagni, F Leoni, G Gromo, A R Coates, D R Blake
Journal: Annals of the Rheumatic Diseases (1994)

OBJECTIVES--To assess the effect of an intra-articular presentation of stress (heat shock) proteins (hsp) on joint inflammation. METHODS--Wistar rats were sensitised with a suspension of heat killed Mycobacterium tuberculosis in oil in the scruff of the neck and challenged intra-articularly with stress protein or M tuberculosis preparations. Inflammation was assessed by joint swelling and, using immunohistology, cellular infiltration of the synovium and antibody induction by an enzyme-linked immunosorbent method. RESULTS--It was shown, for the first time, that the intra-articular administration of a recombinant myobacterial 65 kDa hsp can induce joint inflammation in M tuberculosis sensitised recipients; both powdered M tuberculosis and the purified protein derivative of tuberculin (PPD) produced a similar response, with T cell infiltration of the synovium and a time course typical of delayed type hypersensitivity. This response was specific to the 65 kDa protein as another immunodominant mycobacterial stress protein of 10 kDa was ineffective. Furthermore, intra-articular injection of the 65 kDa hsp induced an antibody response against both the 65 kDa and 10 kDa proteins and the antibody titres continued to rise when knee swelling had subsided. CONCLUSIONS--These results support the hypothesis that 60 kDa proteins are a relevant arthritogenic stimulus in an M tuberculosis background. Moreover, when antigen presentation occurs in the synovium of previously sensitised individuals, circulating antibodies are generated which persist and recognise cross-reactive epitopes on several stress proteins.
Points from Letters: Angor Animi
Authors: J. G. Woolich
Journal: BMJ (1964)

feather-bedded " with tax allowances and incentives the struggles of the G.P.s to improve their existing surgeries or build new ones with discouragement at every turn is one of the iniquities of the present day.Now that we are no longer members of a "fee-raising " profession, if our masters call the tune they must pay the piper in full.
Enface Reconstruction of VSD on RV Septal Surface Using Real-Time 3D Echocardiography
Authors: Kothandam Sivakumar, Anilkumar Singhi, Sreeja Pavithran
Journal: JACC. Cardiovascular imaging (2012)

pictorial representation of ventricular septal defects on the right ventricular septal surface to guide the surgical or interventional closure was often mentally reconstructed based on multiple 2-dimensional echocardiographic images ([1][1]). Three-dimensional imaging was an improvement but needed
Retrograde Versus Antegrade Nerve Sparing During Robot-assisted Radical Prostatectomy: Which Is Better for Achieving Early Functional Recovery?
Authors: Young Hwii Ko, Rafael F. Coelho, Ananthakrishnan Sivaraman, Oscar Schatloff, Sanket Chauhan, Haidar M. Abdul-Muhsin, Rair Jose Valero Carrion, Kenneth J. Palmer, Jun Cheon, Vipul R. Patel
Journal: European Urology (2012)
When I use a word...: Buyers and sellers
Authors: J. Aronson
Journal: BMJ (1997)

These articles about words elicit an interesting postbag. I have recently been asked by F J Langfield of Frenchay in Bristol if I can remind him of the word for the inverse of a monopoly. A monopoly is defined in the Oxford English Dictionary as “the condition of having no competitor in the sale of some commodity or in the exercise of some trade or business.” What then do you call the condition in which you have no competitor in the purchase of some commodity?

Well monopoly comes from two Greek words, μoνoσ …