tbuckley/cabot-search huggingface dataset:
2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: Executive Summary
Authors: Patrick T. O'Gara, Frederick G. Kushner, Deborah D. Ascheim, Donald E. Casey, Mina K. Chung, James A. de Lemos, Steven M. Ettinger, James C. Fang, Francis M. Fesmire, Barry A. Franklin, Christopher B. Granger, Harlan M. Krumholz, Jane A. Linderbaum, David A. Morrow, L. Kristin Newby, Joseph P. Ornato, Narith Ou, Martha J. Radford, Jacqueline E. Tamis-Holland, Carl L. Tommaso, Cynthia M. Tracy, Y. Joseph Woo, David X. Zhao
Journal: Journal of the American College of Cardiology (2012)
NKT Cell-Plasmacytoid Dendritic Cell Cooperation via OX40 Controls Viral Infection in a Tissue-Specific Manner
Authors: Julien Diana, Thibault Griseri, Sylvie Lagaye, Lucie Beaudoin, Elodie Autrusseau, Anne-Sophie Gautron, Céline Tomkiewicz, André Herbelin, Robert Barouki, Matthias von Herrath, Marc Dalod, Agnès Lehuen
Journal: Immunity (2009)
1001 PRAGMATIC ASSESSMENT OF LIVER FIBROSIS DURING METHOTREXATE THERAPY: COMPARISON OF PATIENTS WITH PSORIASIS, RHEUMATOID ARTHRITIS OR CROHN'S DISEASE
Authors: B. Alby-Lepresle, J.-P. Cervoni, E. Monnet, F. Aubin, D. Wendling, E. Toussirot, I. Mermet, M. Nachury, E. Bertolini, F. Carbonnel, V. Bague, P. Calès, V. Di Martino
Journal: Journal of Hepatology (2010)
Effectiveness of Treatment for Non-Small Cell Lung Cancer
Authors: Walter J. Curran
Journal: Annals of Internal Medicine (1990)

Letters15 October 1990Effectiveness of Treatment for Non-Small Cell Lung CancerWalter J. Curran Jr, MDWalter J. Curran Jr, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-8-637 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The article by Johnson and colleagues (1) alleges in its title that the Southeastern Cancer Study Group has shown a lack of survival benefit for thoracic radiotherapy among patients with locally advanced non-small cell lung cancer. A careful reading of the article would suggest otherwise.Of the 272 patients considered evaluable for response, 221 (81%) received either immediate or delayed thoracic radiotherapy as a component of their protocol treatment. This includes 44% to 46% of patients assigned to the vindesine arm who were considered evaluable for survival. When such a major proportion of patients receives a therapy...Reference1. JohnsonEinhornBartolucci DLA. Thoracic radiotherapy does not prolong survival in patients with locally advanced, unresectable non-small cell lung cancer. Ann Intern Med. 1990;113:33-8. LinkGoogle Scholar1. Payne D. Non-small cell lung cancer: should unresectable stage III patients routinely receive high-dose radiation therapy? J Clin Oncol. 1988;6:552-8. CrossrefMedlineGoogle Scholar2. JohnsonEinhornBartolucci DLA. Thoracic radiotherapy does not prolong survival in patients with locally advanced, unresectable non-small cell lung cancer. Ann Intern Med. 1990;113:33-8. LinkGoogle Scholar3. PerezStanleyRubin CKP. A prospective randomized study of various irradiation doses and fractionation schedules in the treatment of inoperable non-oat cell carcinoma of the lung. Cancer. 1980;45:2744-53. CrossrefMedlineGoogle Scholar4. BonomiFinkelsteinRuckdeschel PDJ. Combination chemotherapy versus single agents followed by a combination chemotherapy in stage IV non-small cell lung cancer: a study of the Eastern Cooperative Oncology Group. J Clin Oncol. 1989;7:1602-13. CrossrefMedlineGoogle Scholar5. KaasaThorudHostLienLundSjolie SEHHEI. A randomized study evaluating radiotherapy versus chemotherapy in patients with inoperable non-small cell lung cancer. Radiother Oncol. 1988; 11:7-13. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fox Chase Cancer Center University of Pennsylvania Philadelphia, PA 19111 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClinical stage II non-small cell lung cancer treated with radiation therapy alone:The significance of clinically staged ipsilateral hilar adenopathy (N1 disease) 15 October 1990Volume 113, Issue 8Page: 637-638KeywordsCancer treatmentNon small cell lung cancerRespiratory system procedures Issue Published: 15 October 1990 PDF DownloadLoading ...
Treatment of Intraepithelial Neoplasia
Authors: Paul D. Indman
Journal: JAMA (1984)

To the Editor.—  In a recent QUESTIONS AND ANSWERS column, 1 the use of the CO 2 laser in the treatment of cervical intraepithelial neoplasia (CIN) is discussed. There are several misconceptions that need to be clarified.  First, the term laser cautery is used more than once. When used at high power densities, the CO 2 laser causes vaporization of tissue, resulting in its removal. While there is some thermal damage to the underlying tissue, this is minimal, and less than 1 mm deep. In contrast, hot or cold cautery results in necrosis to an unknown depth of tissue, rather than the actual removal of tissue. Laser treatment of CIN is, therefore, more comparable with conization than cauterization.  Two basic types of laser conizations may be done. In the vaporization cone, the entire transformation zone is vaporized to a measured depth of at least 6 mm. In this type of
"Pop Top" Ingestion: A Technique for Localization
Authors: Roger T. Crenshaw
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Beverage cans with pull-tabs ("pop tops") were introduced as soft drink and beer containers in the mid-1960s. Many people have become accustomed to putting the pop top into the can after opening as an assurance of disposal when the can is emptied. This particular practice is widespread, and the potential medical hazards involved with the inadvertent ingestion or aspiration have been described.<sup>1,2</sup> The use of x-ray, ultrasound, and gas contrast x-ray have been variously reported<sup>3,4</sup>in an attempt to localize the pop top. A simple technique that requires no special equipment or invasion of body integrity was used in the following case with excellent results. <h3>Report of a Case.—</h3> A 20-year-old man arrived at the emergency room with the chief complaint of a pop top stuck in his throat. He had ingested two sandwiches and two cans of beer, and reported that the pop top,
<i>The Tao of Pooh</i> —a philosophy that changed my practice
Authors: Michael Archer
Journal: BMJ (2004)

My mother in law gave me The Tao of Pooh by Benjamin Hoff for Christmas, I suspect because she thought my mentality was suited to the cuddly toy of the title. I dutifully added it to my collection of books to read while on holiday, intending to have a complete break from books and journals about medicine. However, when I settled down to read it, on a sunny beach far from my consulting room, I was struck by its relevance to my work, and The Tao of Pooh has made a greater change to my practice than much of my regular medical reading.

Hoff uses the characters from A A Milne's Winnie the Pooh books to illustrate and …
Prioritization and Organ Distribution for Liver Transplantation
Authors: Oscar Bronsther
Journal: JAMA (1994)

THE CURRENT policies for cadaver kidney distribution were recently discussed inThe Journal.<sup>1</sup>Questions about liver allocation are even more important, because there is not the option of artificial organ support.<sup>2</sup>Two principles of liver deployment have been advocated: efficiency of organ use and urgency of need. <h3>THE EFFICIENCY PRINCIPLE</h3><h3>Single Disease Studies</h3><h3>Primary Biliary Cirrhosis.</h3> —Patients with this disease have been stratified retrospectively into low-, medium-, and high-risk categories, and their actual survival after liver transplantation has been compared with the outcome expected without such intervention.<sup>3</sup>This comparison depended on a Mayo hazard prediction model of the natural history of primary biliary cirrhosis (Table 1).<sup>4</sup>Before the National Institutes of Health Consensus Development Conference of 1983,<sup>5</sup>we reserved liver transplantation candidacy for patients with chronic disease whose life expectancy was a few months.<sup>6</sup>The effect of this restrictive policy could be seen in
Sleeping Beauty-Mediated Transposition and Long-Term Expression in Vivo: Use of the LoxP/Cre Recombinase System to Distinguish Transposition-Specific Expression
Authors: Paul R. Score, Lalitha R. Belur, Joel L. Frandsen, Jennifer L. Guerts, Tomoyuki Yamaguchi, Nikunj V. Somia, Perry B. Hackett, David A. Largaespada, R. Scott McIvor
Journal: Molecular Therapy (2005)

The Sleeping Beauty transposon system (SB) has been shown to mediate nonviral integration of expression constructs resulting in long-term gene expression in several mammalian targets. Often, however, it is difficult to discern long-term expression resulting from transposition vs nonhomologous chromosomal recombination or maintenance of plasmid DNA in an extrachromosomal form. We have designed a system to silence expression from nontransposed sequences, making it possible to determine more specifically the amount of expression resulting from transposition. A transposon plasmid, pT2F/Cage (carrying a murine erythropoietin (Epo) gene transcriptionally regulated by the ubiquitously expressed CAGS promoter), was engineered to contain LoxP sites positioned so as to interrupt expression upon Cre-mediated recombination. Upon transposition these sites become segregated, thus protecting the expression construct from Cre-mediated recombination and subsequent silencing. Interferon-inducible Mx1Cre mice were administered pT2F/Cage with or without transposase-encoding plasmid. At 2 to 4 weeks postinjection, in the absence of SB transposase, Cre induction reduced Epo expression to about 1% of that seen in the group that was administered transposase-encoding plasmid, which maintained Epo levels near those of the uninduced groups. Southern hybridization analysis and plasmid rescue of transfected tissue supported the efficient Cre-mediated silencing of nontransposed sequences. These results indicate a substantial level of DNA-mediated expression not associated with transposition, but which can be quantitatively distinguished from transposition by its sensitivity to Cre recombinase. The results also provide additional evidence for the effectiveness of the Sleeping Beauty transposon system as an in vivo DNA-mediated gene transfer strategy for achieving long-term expression.
The effects of pioglitazone on cerebrovascular resistance in patients with type 2 diabetes mellitus
Authors: Jong Suk Park, Min Ho Cho, Kyung Yul Lee, Chul Sik Kim, Hai Jin Kim, Ji Sun Nam, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
Journal: Metabolism (2007)
Preventing exacerbations of chronic bronchitis and COPD
Authors: A. Ekberg-Jansson
Journal: BMJ (2001)

Papers p 1271 

Exacerbations of chronic obstructive pulmonary disease affect quality of life and the cost of managing the disease. Though the long term effects of hypersecretion on the deterioration of ventilatory function in patients with chronic obstructive pulmonary disease have been debated for many years,1 recent data show a good correlation between hypersecretion and long term deterioration of ventilatory function in these patients.2 This is why mucolytics, which seem to have an effect on hypersecretory exacerbations,3 might also influence disease progression in chronic obstructive pulmonary disease. Exacerbations are important events for patients with chronic bronchitis in that they negatively affect quality of life.1 Exacerbations also have socio-economic consequences.2 Therapies aiming at reducing the occurrence and severity of exacerbations are therefore of interest.

The Cochrane review in this week's issue of the BMJ reports a meta-analysis of drugs considered to have mucolytic effects (p 1271).3 Twenty two studies of 10 drugs were included. Treated patients showed a significant reduction over controls in the number of exacerbations …
Points from letters: Call to negotiators
Authors: M Wynn
Journal: BMJ (1977)

should be deprived of benefit from their husbands' war service.Interest at 3-50o compound, without tax relief, payable to secure war service pension compares very unfavourably with the miserable 210O simple-taxable-paid since 1948 on our compensation for loss of goodwill.A colleague of mine with six years of war service recently wrote to the appropriate department of the Ministry of Defence seeking confirmation of the dates of his war service.I understand th'at the reply
THE PATHOLOGY AND PATHOGENESIS OF PERICARDITIS.
Authors: JOSEPH McFARLAND
Journal: JAMA (1901)

The ancients supposed disease of the heart to be incompatible with life, the heart being the center of life. Galen, in the second century after Christ, observed pericarditis in the lower animals and inferred its occurrence in man. Before this knowledge had been gleaned, all peculiarities of the structure or appearance of the heart were supposed to denote attributes of character. Thus, Haller speaks of the "hairy hearts" of Leonidas, Lysander and Aristomenes, as indicative of great bravery, those "hairy hearts" undoubtedly being viscera covered with stringy fibrin. <h3>ETIOLOGY.</h3> The disease is now known to be of frequent occurrence. It is most common in adolescence and early adult life, between the ages of 15 and 30. It occurs in childhood and in infancy, and rarely in the fetus. It also occurs in late adult lif and sometimes in senility. Knopf saw pericarditis 10 times among 459 cases of diseases of
Pinhole Imaging: Utility in Testicular Imaging in Children
Authors: MICHAEL J. GELFAND, PATRICIA J. WILLIAMS, JENS G. ROSENKRANTZ
Journal: Clinical Nuclear Medicine (1980)

Pinhole imaging of the testis was done in ten boys with suspected testicular torsion. In three of the ten cases, pinhole images were easier to interpret than images obtained with a converging collimator. In six of the ten cases, pinhole images were required for interpretation of the study, because converging images could not be interpreted.
Transforming Growth Factor-β, Estrogen, and Progesterone Converge on the Regulation of p27Kip1 in the Normal and Malignant Endometrium
Authors: Jon Lecanda, Trilok V. Parekh, Patricia Gama, Ke Lin, Vladimir Liarski, Seth Uretsky, Khush Mittal, Leslie I. Gold
Journal: Cancer Research (2007)

Hormones and growth factors regulate endometrial cell growth. Disrupted transforming growth factor-beta (TGF-beta) signaling in primary endometrial carcinoma (ECA) cells leads to loss of TGF-beta-mediated growth inhibition, which we show herein results in lack of up-regulation of the cyclin-dependent kinase inhibitor p27(Kip1) (p27) to arrest cells in G(1) phase of the cell cycle. Conversely, in normal primary endometrial epithelial cells (EECs), TGF-beta induces a dose-dependent increase in p27 protein, with a total 3.6-fold maximal increase at 100 pmol/L TGF-beta, which was 2-fold higher in the nuclear fraction; mRNA levels were unaffected. In addition, ECA tissue lysates show a high rate of ubiquitin-mediated degradation of p27 compared with normal secretory-phase endometrial tissue (SE) such that 4% and 89% of recombinant p27 added to the lysates remains after 3 and 20 h, respectively. These results are reflected in vivo as ECA tissue lacks p27 compared with high expression of p27 in SE (P < or = 0.001). Furthermore, we show that estrogen treatment of EECs causes mitogen-activated protein kinase-driven proteasomal degradation of p27 whereas progesterone induces a marked increase in p27 in both normal EECs and ECA cells. Therefore, these data suggest that TGF-beta induces accumulation of p27 for normal growth regulation of EECs. However, in ECA, in addition to enhanced proteasomal degradation of p27, TGF-beta cannot induce p27 levels due to dysregulated TGF-beta signaling, thereby causing 17beta-estradiol-driven p27 degradation to proceed unchecked for cell cycle progression. Thus, p27 may be a central target for growth regulation of normal endometrium and in the pathogenesis of ECA.
Amodiaquine-induced Agranulocytosis: Toxic Effect of Amodiaquine in Bone Marrow Cultures In Vitro
Authors: D. E. Lind, J. A. Levi, P. C. Vincent
Journal: BMJ (1973)

A case of agranulocytosis is reported in which amodiaquine, to which the patient had been exposed, was found to be toxic to the patient's bone marrow cells when these were cultured in an agar colony system in vitro. This technique should be investigated in other patients with agranulocytosis as a possible means of detecting toxic agents.
Effects of preventive home visits to elderly people.
Authors: E van Rossum, C M Frederiks, H Philipsen, K Portengen, J Wiskerke, P Knipschild
Journal: BMJ (1993)

OBJECTIVES--To assess the effect of preventive home visits by public health nurses on the state of health of and use of services by elderly people living at home. DESIGN--Randomised controlled trial. SETTING--General population of elderly people in one of the southern regions of the Netherlands. SUBJECTS--580 subjects aged between 75 and 84 years randomly allocated to intervention (292) or control (288) group. INTERVENTIONS--Four visits a year over three years in intervention group. Control group received no home visits. MAIN OUTCOME MEASURES--Self rated health, functional state, well being, loneliness, aspects of the mental state (depressive complaints, memory disturbances), and mortality. Use of services and costs. RESULTS--Visits had no effect on the health of the subjects. In the group visited no higher scores were seen on health related measures, fewer died (42 (14%) v 50 (17%)), and community care increased slightly. In the control group more were referred to outpatient clinics (166 (66%) v 132 (55%)), and they had a 40% increased risk of admission (incidence rate ratio 1.4; 90% confidence interval 1.2 to 1.6). No differences were found in long term institutional care, and overall expenditure per person in the intervention group exceeded that in the control group by 4%. Additional analyses showed that visits were effective for subjects who initially rated their health as poor. CONCLUSIONS--Preventive home visits are not beneficial for the general population of elderly people living at home but might be effective when restricted to subjects with poor health.
Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity
Authors: Daniela Pende, Stefania Marcenaro, Michela Falco, Stefania Martini, Maria Ester Bernardo, Daniela Montagna, Elisa Romeo, Céline Cognet, Miryam Martinetti, Rita Maccario, Maria Cristina Mingari, Eric Vivier, Lorenzo Moretta, Franco Locatelli, Alessandro Moretta
Journal: Blood (2008)
Cytokines in human renal interstitial fibrosis. I. Interleukin-1 is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts
Authors: Gerhard Lonnemann, Leland Shapiro, Gabi Engler-Blum, Gerhard A. Müller, Karl M. Koch, Charles A. Dinarello
Journal: Kidney International (1995)
A Phase II Study of Trastuzumab Emtansine in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer Who Were Previously Treated With Trastuzumab, Lapatinib, an Anthracycline, a Taxane, and Capecitabine
Authors: Ian E. Krop, Patricia LoRusso, Kathy D. Miller, Shanu Modi, Denise Yardley, Gladys Rodriguez, Ellie Guardino, Michael Lu, Maoxia Zheng, Sandhya Girish, Lukas Amler, Eric P. Winer, Hope S. Rugo
Journal: Journal of Clinical Oncology (2012)

To determine whether the antibody-drug conjugate trastuzumab emtansine (T-DM1), which combines human epidermal growth factor receptor 2 (HER2) -targeted delivery of the potent antimicrotubule agent DM1 with the antitumor activity of trastuzumab, is effective in patients with HER2-positive metastatic breast cancer (MBC) who have previously received all standard HER2-directed therapies.In this single-arm phase II study, T-DM1 3.6 mg/kg was administered intravenously every 3 weeks to patients with HER2-positive MBC who had prior treatment with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine. The primary objectives were overall response rate (ORR) by independent review and safety.Among 110 pretreated patients (median, seven prior agents for MBC; median follow-up, 17.4 months), the ORR was 34.5% (95% CI, 26.1% to 43.9%), clinical benefit rate was 48.2% (95% CI, 38.8% to 57.9%), median progression-free survival (PFS) was 6.9 months (95% CI, 4.2 to 8.4 months), and median duration of response was 7.2 months (95% CI, 4.6 months to not estimable). In patients with confirmed HER2-positive tumors (n = 80 by retrospective central testing), the response rate was 41.3% (95% CI, 30.4% to 52.8%), and median PFS was 7.3 months (95% CI, 4.6 to 12.3 months). Most adverse events were grades 1 to 2; the most frequent grade ≥ 3 events were thrombocytopenia (9.1%), fatigue (4.5%), and cellulitis (3.6%).T-DM1 is well tolerated and has single-agent activity in patients with HER2-positive MBC who have previously received both approved HER2-directed therapies and multiple chemotherapy agents. T-DM1 may be an effective new treatment for this patient population.
Abstract 2676: A secreted tissue engineered extracellular matrix (shECM) prevents recurrence in post-resection pancreatic cancer models
Authors: Emmett Pinney, Rhiana Menen, Mohamed Hassanein, Mayra Montes-Camacho, Gail Naughton, Michael Bouvet, Robert M. Hoffman
Journal: Cancer Research (2012)

Abstract Pancreatic cancer is a highly treatment-resistant cancer. Gemcitabine, which is first-line therapy, results in toxicity without meaningful survival benefit. We report here that a extracellular matrix (ECM) secreted by human embryone fibroblasts in culture inhibit human pancreatic cancer growth and post-surgical recurrence in an orthotopic nude mouse models. Post-resection, all untreated control mice had recurrent disease. In contrast, only 2 of 8 mice (p=0.004) in the treatment group had palpable masses after 6 weekly intravenous treatments. In a second study, targeting the one surgical site with ECM treatment followed by 8 weekly i.p. treatments of ECM, 7 of 8 treated mice survived beyond 10 weeks while none of the untreated control mice survival 8 weeks. No measurable toxicity was observed in the treatment group. These results demonstrate the potential of ECM treatment of pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2676. doi:1538-7445.AM2012-2676
Problems With Condom Catheters
Authors: Jessie L. Dickerson
Journal: JAMA (1990)

To the Editor.—  This letter is in response to the question regarding Problems With Condom Catheters.1We often deal with these problems while treating patients with spinal cord injury. We would like to share our experiences and hope this information will help the patient whose condom slides off every time his penis retracts or becomes erect.  Method 1.—  In addition to the obvious need for proper preparation of the skin with thorough washing and drying, it may be necessary to remove any excessive hair from around the penile shaft and base of the penis by clipping the pubic hair. Apply a coat of skin bond (cement) or benzoin tincture to the penile shaft. Allow to dry and become tacky before proceeding (approximately 30 seconds). Apply two-sided adhesive tape directly to the shaft of the penis in a spiral fashion. Unroll the condom catheter slowly onto the penis over the