Rhabdomyolysis and Renal Failure in Hypothyroidism
Authors: PAUL B. HALVERSON
Journal: Annals of Internal Medicine (1979)

Brief Reports1 July 1979Rhabdomyolysis and Renal Failure in HypothyroidismPAUL B. HALVERSON, M.D., FRANKLIN KOZIN, M.D., LAWRENCE M. RYAN, M.D., A. R. SULAIMAN, M.B.,B.S.PAUL B. HALVERSON, M.D., FRANKLIN KOZIN, M.D., LAWRENCE M. RYAN, M.D., A. R. SULAIMAN, M.B.,B.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-57 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMuscle involvement is a frequent manifestation of hypothyroidism (1, 2). Findings include myalgias, stiffness, weakness, elevated muscle enzymes, electromyographic abnormalities, and histologic changes. Serious muscle involvement is distinctly uncommon and rhabdomyolysis has not been recognized previously as a complication of hypothyroidism. We report a case of renal failure produced by massive muscle necrosis and myoglobinuria in a hypothyroid patient.A 60-year-old white woman presented to Milwaukee County General Hospital in October 1976, with complaints of weakness, anorexia, dysuria for 2 weeks, decreased urine output for 1 week, cold intolerance, and numbness in her feet. She was found to have a...References1. RAMSEY I. Thyroid Disease and Muscle Dysfunction. Chicago: Yearbook Medical Publishers; 1974:126. CrossrefGoogle Scholar2. INGBAR S and WOEBER K. The thyroid gland. In: WILLIAMS RH, ed. Textbook of Endocrinology. Philadelphia: W. B. Saunders Co.; 1974:95-232. Google Scholar3. HOCHBERG M, KOPPES G, EDWARDS C, BARNES H, and ARNETT F. Hypothyroidism presenting as a polymyositis-like syndrome. Arthritis Rheum. 1976;19:1353-66. CrossrefMedlineGoogle Scholar4. NICKEL S, FRAME B, BEBIN J, TOURTELLOTTE W, PARKER J, and HUGHES B. Myxedema neuropathy and myopathy: a clinical and pathologic study. Neurology. 1961;11:125-37. CrossrefMedlineGoogle Scholar5. CRAIG F and SMITH J. Serum creatine phosphokinase activity in altered thyroid states. J Clin Endocrinol Metab. 1965;25:723-31. CrossrefMedlineGoogle Scholar6. FLEISHER G, MCCONAHEY W, and PANKOW M. Serum creatine kinase, lactic dehydrogenase, and glutamic-oxaloacetic transaminase in thyroid diseases and pregnancy. Mayo Clinic Proc. 1965;40:300-11. MedlineGoogle Scholar7. GRIFFITHS P. Serum enzymes in diseases of the thyroid gland. J Clin Pathol. 1965;18:660-3. CrossrefMedlineGoogle Scholar8. GOLDMAN J, MATZ R, MORTIMER R, and FREEMAN R. High elevations of creatine phosphokinase in hypothyroidism: an isoenzyme analysis. JAMA. 1977;238:325-6. CrossrefMedlineGoogle Scholar9. ADAMS R. Diseases of Muscle, 3rd ed. Hagerstown, Maryland: Harper & Row; 1975:481. Google Scholar10. MARSHALL R and MCCAUGHEY W. Hypothermic myxedema coma with muscle damage and acute renal tubular necrosis. Lancet. 1956;2:754-7. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL B. HALVERSON, M.D.; FRANKLIN KOZIN, M.D.; LAWRENCE M. RYAN, M.D.; A. R. SULAIMAN, M.B.,B.S.Affiliations: The Medical College of Wisconsin Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAn Interesting Case of Hypothyroidism Associated Acute Kidney InjuryRhabdomyolysis Caused by Hypothyroidism: Research ProgressHypothyroidism-associated rhabdomyolysis: A new case report and review of the reported casesSo slow, so fast, a case of nivolumab-induced hypothyroidism with subsequent rhabdomyolysisAcute Flaccid Paralysis in an 11-Year-OldA rare cause of acute kidney injury: hypothyroidism / Akut böbrek hasarının nadir bir nedeni: HipotiroidizmAcute-on-Chronic Kidney Injury in Thyroid Hormone Withdrawal: A Case with Possible Implications for Radioactive Iodine PlanningRhabdomyolysis due to severe hypothyroidism culminating in uremic encephalopathyRhabdomyolysis and MyoglobinuriaRhabdomyolysis and Acute Renal Impairment in a Patient with Hypothyroidism: A Case ReportAnti-PD1 Following Ipilimumab for Mucosal Melanoma: Durable Tumor Response Associated with Severe Hypothyroidism and RhabdomyolysisSarcopenia and Myopathies in the ElderlyRole of Thyroid Disease in the Development of Statin-Induced MyopathyInsulin resistance in an 18-year-old patient with Down syndrome presenting with hyperglycaemic coma, hypernatraemia and rhabdomyolysisA Case of Panhypopituitarism with RhabdomyolysisChronic autoimmune thyroiditis and rheumatic manifestationsThyroïdite chronique auto-immune et manifestations rhumatologiquesReversible Myopathy and Renal ImpairmentSimvastatin–Fluconazole Causing RhabdomyolysisRhabdomyolyse und MyoglobinurieReversible acute renal failure associated with hypothyroidism: Report of four cases with a brief review of literatureHypothyroidism as a Cause of Rhabdomyolysis.MYOPATHIES IN THE ELDERLYMuscle Aches and Fatigue in a Man with Elevated Creatine KinaseRhabdomyolysis and Myoglobinuric Renal Failure in Trauma and Surgical Patients: A ReviewRenal failure in a patient with profound hypothyroidismAcute Compartment Syndrome in a Hypothyroid PatientRhabdomyolysis: a review of the literatureDepression and Chronic Fatigue in AthletesPrevalence and Predictors of Rhabdomyolysis in Patients with HypokalemiaMyopathie hypothyroïdienne : à propos d'un cas avec élévation majeure de la créatine phosphokinase, myoglobinémie et insuffisance rénale transitoireRhabdomyolysis and acute renal failureMYOPATHIES ASSOCIATED WITH HYPOTHYROIDISM: A REVIEW BASED UPON 13 CASESMyoglobinuria, 1984 1 July 1979Volume 91, Issue 1Page: 57-58KeywordsElectromyographyEnzymesHypothyroidismMusclesMyalgiaNecrosisRenal failureRhabdomyolysisStiffnessUrine ePublished: 1 December 2008 Issue Published: 1 July 1979 PDF downloadLoading ...