tbuckley/cabot-search huggingface dataset:
Rehabilitation in Endocrine Patients: A Novel Psychosomatic Approach
Authors: Nicoletta Sonino, Giovanni A. Fava
Journal: Psychotherapy and Psychosomatics (2007)

Long-standing endocrine disorders may imply a degree of irreversibility of the pathological process and induce highly individualized affective responses. The psychosocial impairment that is associated with incomplete remission from endocrine illness suggests the need for an innovative approach to treatment, introducing in clinical endocrinology the concept of rehabilitation, which in other fields of medicine is already established. This new proposal stems from a number of unresolved issues related to the high prevalence of psychosocial impairment in patients adequately treated for various endocrine conditions. Indeed, rehabilitation in endocrinology may be indicated in the following cases: (a) delayed recovery after appropriate treatment; (b) discrepancy between endocrine status and current functioning; (c) presence of a decline in physical and social functioning; (d) persistence of important comorbidity, with special reference to psychiatric disturbances; (e) assessment of abnormal illness behavior; (f) problems with lifestyle and risk behavior, and (g) potential role of stress in endocrine disturbances. The endocrine rehabilitation team should ideally include a trained clinical endocrinologist, a physical therapist and a psychologist, with opportunities for other specialist consultations. The goal of such service would be to ensure education, support and specific interventions, helping the patient and his/her family to achieve optimal coping with the difficulties of the recovery process. Due to its comprehensive psychosomatic characterization, this new approach would likely increase the chances of obtaining full recovery in a significant proportion of patients and has the potential of being cost-effective.
Abstract 5295: Dysregulated <i>miR-363</i> affects head and neck cancer invasion and metastasis by targeting <i>PDPN</i> gene.
Authors: Wantao Chen
Journal: Cancer Research (2013)

Abstract Head and neck squamous cell carcinoma (HNSCC) is characterised by an elevated capacity for cell invasion and lymph node metastasis. The cause remains to be determined. Recent studies suggest that microRNAs can regulate the evolution of malignant behaviours by regulating multiple target genes. In this study, we first confirmed that miR-363 is down-regulated in HNSCC tissues with lymph node metastasis and cell lines with highly invasive capacity. We also found that podoplanin (PDPN) is up-regulated in the metastatic HNSCC tissues, and ectopic over-expression of miR-363 suppressed the metastatic behaviour of HNSCC cells by directly targeting PDPN. These data support a key role of miR-363-PDPN in head and neck cancer metastasis by regulating cellular invasion and migration. Citation Format: Wantao Chen. Dysregulated miR-363 affects head and neck cancer invasion and metastasis by targeting PDPN gene. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5295. doi:10.1158/1538-7445.AM2013-5295
Methyldopa and Hypertension
Authors: S. R. F. Whittaker, R. Robinson, A. W. Stott
Journal: BMJ (1963)

EDICALJOURNASide-effect of Phenindione SIR,-I would like to bring to the attention of other physicians a brownish-yellow discoloration of the finger- nails which became evident in one of my patients who was treated with long-term anticoagulants for coronary disease.This patient was started on phenindione in April, 1962, and put on a long-term maintenance dose on May 2, 1962, but in August, 1962, he noted that the peripheral third of every finger-nail in the hands had become brownish-yellow in colour, and this has persisted up to the present date.He is still on a maintenance therapy of "dindevan " (phenindione) 75 mg.daily.I would be very interested to learn if other physicians have noted this unusual side-effect of phenindione.-
Axillary vs Sentinel Lymph Node Dissection for Invasive Breast Cancer
Authors: Seenu Vuthaluru
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IMMUNOLOGICAL RELATIONSHIPS OF CELL CONSTITUENTS OF PNEUMOCOCCUS
Authors: O. T. Avery, M. Heidelberger
Journal: The Journal of Experimental Medicine (1923)

1. The protein precipitated by acetic acid from solutions of pneumococci shows chemical reactions characteristic of nucleoprotein and mucoid. 2. The protein of pneumococcus, as contrasted with the non-protein soluble specific substance, exhibits species specificity rather than the type specificity characteristic of the latter.
Production of lymphotoxin by isolated human tonsillar B lymphocytes and B lymphocyte cell lines.
Authors: S S Sung, L K Jung, J A Walters, E W Jeffes, G A Granger, S M Fu
Journal: Journal of Clinical Investigation (1989)

The expression of lymphotoxin (LT) mRNA and cytokine in human tonsillar B cells and B cell lines was examined by Northern blots and cytotoxicity assays, respectively. In tonsillar B cells, phorbol myristate acetate (PMA) or Staphylococcus aureus Cowan l (SAC) alone induced low levels of LT mRNA accumulation. However, SAC and anti-mu were strongly synergistic with PMA in this induction. Peak LT mRNA expression in tonsillar B cells stimulated by PMA plus SAC occurred between 48 and 72 h and was approximately half as much as that in PMA plus anti-CD3-stimulated T cells. Cyclosporine A was not effective in inhibiting LT mRNA accumulation by stimulated tonsillar B cells. A number of B cell lines could also be stimulated by PMA to express LT mRNA. Peak accumulation of LT mRNA in the cell line RPMI 1788 stimulated with PMA peaked about 8 h. A23187 in combination with PMA caused this accumulation to increase slightly and to peak earlier. The cytotoxic effects in the supernatants of stimulated B cells were contributed mostly by LT. The results indicate that tonsillar B cells are important in LT production and that there are important differences in the stimulation requirements for LT production and in LT mRNA expression kinetics between tonsillar B cells and B cell lines.
A Few Words With Socrates About Doctors
Authors: Charles Hamilton
Journal: JAMA (1967)

After spending a rather long time in the steam room, I was sitting on a bench in the coolingoff room, my head back-tilted against the wall, trying not to think of the things my doctor had been saying, in his crude way, about my age and blood pressure. I was just drifting into the twilight sleep that always follows me after about 30 minutes of steam life, when there was a gentle squelch beside me and I opened my eyes, intending to give a nasty look to whoever sat there. To my surprise, it was Socrates, unmistakable even in the nude, with steam wafting around him. His solid figure and friendly eyes offset his bulldog face and I felt a strong desire to communicate with a man of such humanity and wisdom. "Why," I said, "this is indeed a pleasure: it must be 40 years since I had the privilege
ETIOLOGY OF PERICARDITIS.
Authors: JAMES T. WHITTAKER
Journal: JAMA (1884)

Pericarditis is a disease of greater frequency than is generally believed.The statement made by the author of this paper in the Cincinnati Academy of Medicine that pericarditis is ordinarily oftener overl ooked than recognized, having been denied by several members, was strikingly confirmed by an ex-interne of one of our largest hospitals, who observed that of the five cases which had occurred in his service, the diagnosis was made in intra vitam in no single case.The existence of the disease in every case was made apparent only on the post-mortem table.Maurice Letulle, Gaz.Med. de Paris, 22-50, 1879-80, remarks that of all acute or chronic diseases, pericarditis oftenest runs a latent course.
Testing the Efficacy of Antiarrhythmic Drugs
Authors: Jeffrey L. Anderson, Jay W. Mason
Journal: New England Journal of Medicine (1986)

IN this issue, Kim and colleagues report interesting results in patients with life-threatening ventricular tachyarrhythmias who underwent both ambulatory (Holter) electrocardiographic monitoring and electrophysiologic study (programmed electrical stimulation) to test the efficacy of antiarrhythmic drugs.1 They observed that the clinical outcome in patients who continued to have inducible ventricular tachycardia while receiving drug therapy was as good as the outcome in those who did not, as long as the former did not have frequent spontaneous ventricular ectopy during Holter monitoring. Their observations provide an opportunity to discuss the advantages and limitations of these two techniques for evaluating drug therapy for . . .
Stuck in the Middle: The Many Moral Challenges With Bariatric Surgery
Authors: Bjørn Hofmann
Journal: The American Journal of Bioethics (2010)

Abstract Bariatric surgery is effective on short- and medium-term weight loss, reduction of comorbidities, and overall mortality. A large and increasing portion of the population is eligible for bariatric surgery, which increases instant health care costs. A review of the literature identifies a series of ethical challenges: unjust distribution of bariatric surgery, autonomy and informed consent, classification of obesity and selecting assessment endpoints, prejudice among health professionals, intervention in people's life-world, and medicalization of appearance. Bariatric surgery is particularly interesting because it uses surgical methods to modify healthy organs, is not curative, but offers symptoms relief for a condition that it is considered to result from lack of self-control and is subject to significant prejudice. Taking the reviewed ethical issues into account is important when meeting persons eligible for bariatric surgery, as well as in the assessment of and decision making on surgery for obesity. Keywords: autonomybariatric surgerydiscriminationjusticeoverweightprejudice Acknowledgments I am most grateful to the reviewers and to colleagues at the Section for medical ethics at the University of Oslo for wise comments and valuable suggestions.
Role of doxapram in reducing pulmonary complications after major surgery.
Authors: T H Gawley, J W Dundee, P K Gupta, C J Jones
Journal: BMJ (1976)

In a double-blind study patients given a single dose of doxapram 1-5-2-0 mg/kg combined with morphine postoperatively had a significantly lower incidence of reflex postoperative cough and expectoration of purulent sputum than patients given morphine alone. They also had significantly higher arterial oxygen tensions five days postoperatively. Smaller differences were found with naloxone combined with morphine.
Blindness After Anesthesia
Authors: Stephen Slogoff
Journal: JAMA (1980)

To the Editor.—  We would like to take exception to one consultant's response (243:1187, 1980) to the question of cause of circulatory collapse and subsequent cortical blindness in a 9-year-old child immediately after release of an arm tourniquet during operation for hemangioma of the hand.  The consultant attributed the circulatory collapse to release of acid metabolites from the ischemic arm with consequent myocardial depression from metabolic acidosis. His supporting reference 1 demonstrated that release of a leg tourniquet after 75 minutes of ischemia in 14 adults led to a peak increase in mean base deficit of 2.0 mEq/L five minutes after release. We believe an acidosis of this magnitude in a healthy child, even during halothane and nitrous oxide anesthesia, is incapable of producing measurable decrements in myocardial performance, since transient base deficits of this magnitude occur after release of cross-clamped abdominal aortas after aneurysm resection without myocardial depression in patients
Correction: Impotence and Antihypertensive Drugs
Authors: ANIL K. MANDAL
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 August 1980Correction: Impotence and Antihypertensive DrugsANIL K. MANDAL, M.D.ANIL K. MANDAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-2-382_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: There is an important error in the article "Sexual Function in Diabetic Patients" in Part 2 of the February 1980 issue (1). On p. 332, on the right-hand column, paragraph 1, line 7, the author has said that many of these drugs (that is, antihypertensive drugs) are sympathomimetic. This is a mistake, because these drugs are not sympathomimetic. All antihypertensive drugs are sympathetic inhibitors either centrally through hypothalamus or peripherally through receptors. In other words, they are to be considered as sympatholytic drugs. Extending this connotation it may be stated further that all drug groups mentioned here...References1. ELLENBERG M. Sexual function in diabetic patients. Ann Intern Med. 1980;92(Part2):331-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The University of Oklahoma at Oklahoma City Health Sciences Center Oklahoma City, OK PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1980Volume 93, Issue 2Page: 382-382KeywordsDrugsErectile dysfunctionHypothalamus Issue Published: 1 August 1980 PDF DownloadLoading ...
Predicting the Risk of Venous Thromboembolism in Patients Hospitalized With Heart Failure
Authors: Alexandre Mebazaa, Theodore E. Spiro, Harry R. Büller, Lloyd Haskell, Dayi Hu, Russell Hull, Geno Merli, Sebastian W. Schellong, Alex C. Spyropoulos, Victor F. Tapson, Yoriko De Sanctis, Alexander T. Cohen
Journal: Circulation (2014)

Whether heart failure (HF) increases the risk of venous thromboembolism (VTE) is not well established. In the phase III MAGELLAN (Multicenter, rAndomized, parallel Group Efficacy and safety study for the prevention of venous thromboembolism in hospitalized medically iLL patients comparing rivaroxabAN with enoxaparin) trial, extended-duration rivaroxaban was compared with standard-duration enoxaparin followed by placebo for VTE prevention in 8101 hospitalized acutely ill patients with or without HF. The aim of this analysis was to evaluate the relationship between HF severity and the risk of VTE in MAGELLAN patients.Hospitalized patients diagnosed with HF were included according to New York Heart Association class III or IV at admission (n=2593). HF severity was determined by N-terminal probrain natriuretic peptide (NT-proBNP) plasma concentrations (median 1904 pg/mL). Baseline plasma D-dimer concentrations ranged from 0.6 to 1.7 μg/L for the less and more severe HF subgroups. Patients with more severe HF had a greater incidence of VTE versus patients with less severe HF, with a significant trend up to Day 10 (4.3% versus 2.2%; P=0.0108) and Day 35 (7.2% versus 4.1%; P=0.0150). Multivariable analysis confirmed that NT-proBNP concentration was associated with VTE risk up to Day 10 (P=0.017) and D-dimer concentration with VTE risk up to Day 35 (P=0.005). The association between VTE risk and HF severity that was observed in the enoxaparin/placebo group was not seen in the extended-duration rivaroxaban group.Patients with more severe HF, as defined by high NT-proBNP plasma concentration, were at increased risk of VTE. NT-proBNP may be useful to identify high short-term risk, whereas elevated D-dimer may be suggestive of high midterm risk.URL: http://www.clinicaltrials.gov. Unique identifier: NCT00571649.
An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens
Authors: Wendy M. Leisenring, Paul J. Martin, Effie W. Petersdorf, Anne E. Regan, Nada Aboulhosn, Jean M. Stern, Saundra N. Aker, Raymond C. Salazar, George B. McDonald
Journal: Blood (2006)
L-leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway
Authors: Elspeth M. Payne, Maria Virgilio, Anupama Narla, Hong Sun, Michelle Levine, Barry H. Paw, Nancy Berliner, A. Thomas Look, Benjamin L. Ebert, Arati Khanna-Gupta
Journal: Blood (2012)
Real progress with disciplining doctors
Authors: H Jacobs, P J Tomlin
Journal: BMJ (1989)

in immunocompromised patients (S E Young, personal communication).Not onlye does DF-2 infection have similar transmission and clinical expression to P multocida infection but the organism is also sensitive to penicillin.I wonder whether yet other domestic zoonoses will come to light, initially in more susceptible and investigated subjects, and later in non-immunocompromised subjects, who might anvway be treated blindly with penicillin or even recover spontaneously; such an illness could easily be attributed to a "virus."W P A WHITEHOUSE Hopc Hospital.SaltfOrd,
Brief Psychotherapy with Lung Cancer Patients
Authors: J.A.C. Bleeker
Journal: Psychotherapy and Psychosomatics (1978)

Case Reports| February 16 2010 Brief Psychotherapy with Lung Cancer Patients Subject Area: Psychiatry and Psychology J.A.C. Bleeker J.A.C. Bleeker Amsterdam Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 282–287. https://doi.org/10.1159/000287142 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J.A.C. Bleeker; Brief Psychotherapy with Lung Cancer Patients. Psychother Psychosom 31 December 1978; 29 (1-4): 282–287. https://doi.org/10.1159/000287142 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Prabhakar Shankar Phatak
Authors: J. Phatak, N. Parry-Jones
Journal: BMJ (2012)

Born into a Maharashtrian Chitpavan Brahmin family of lawyers and priests, Prabhakar Shankar Phatak (“Prabhu”) chose a different path, joining Nagpur Medical College in 1954. In 1961 he came to the UK to pursue higher …
An evaluation of Mealey's hypotheses based on psychopathy checklist: Identified groups
Authors: David S. Kosson, Joseph P. Newman
Journal: Behavioral and Brain Sciences (1995)

Abstract Although Mealey's account provides several interesting hypotheses, her integration across disparate samples renders the value of her explanation for psychopathy ambiguous. Recent evidence on Psychopathy Checklist-identified samples (Hare, 1991) suggests primary emotional and cognitive deficits inconsistent with her model. Whereas high-anxious psychopaths display interpersonal deficits consistent with Mealey's hypotheses, low-anxious psychopaths' deficits appear more sensitive to situational parameters than predicted.