The Clinical Significance of Leucopenia with Special Reference to Idiopathic Neutropenia
Authors: STACY R. METTIER
Journal: Annals of Internal Medicine (1933)

Article1 January 1933The Clinical Significance of Leucopenia with Special Reference to Idiopathic NeutropeniaSTACY R. METTIER, M.D., F.A.C.P., HARVEY T. OLSAN, M.D.STACY R. METTIER, M.D., F.A.C.P.Search for more papers by this author, HARVEY T. OLSAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-7-855 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development of leucopenia without apparent cause in a previously healthy individual is a subject about which there has been considerable discussion in recent years. Leucopenia brought on by definite etiologic factors such as certain bacterial and protozoan infections, toxic chemicals, or destruction of the bone marrow by tumor processes is readily understandable. Here the problem is concerned chiefly with diagnosis, and eradication or alleviation of the primary cause. There are instances of leucopenia, however, that are not so readily explained, and in which the cause remains obscure. In the medical literature one may find such conditions designated as "granulopenia",...References1 DOANCUNNINGHAMSABIN CARSFR: Experimental studies on the origin and maturation of avian and mammalian red blood cells, Contrib. Embryol. Carnegie Inst., Wash., 1925, xvi, 163-226. Google Scholar2 ROBERTSKRACKE SRRR: Agranulocytosis; its classification, cases and comments illustrating granulopenic trend from 8,000 blood counts in the South, ANN. INT. MED., 1931, v, 40-51. LinkGoogle Scholar3 MILLS ES: Idiopathic aplastic anemia or aleukia hemorrhagica, Am. Jr. Med. Sci., 1931, clxxxi, 521-533. Google Scholar4 SCHULTZ W: Über eigenartige Halserkrankungen (a) Monozytenangina, (b) Gangräneszierende Prozesse und Defekt des Granulozytensystems, Deutsch. med. Wchnschr., 1922, xlviii, 1495-1496. Google Scholar5 BLUMER G: Agranulocytic blood picture in conditions other than angina, Am. Jr. Med. Sci., 1930, clxxix, 11-16. CrossrefGoogle Scholar6 THOMPSON WP: Abnormalities in the white blood cell response, leukoid, atypical leukemic and leukopenic blood pictures, Am. Jr. Med. Sci., 1931, clxxxii, 334-352. CrossrefGoogle Scholar7 ROSEHAUSER EKM: The identity of the so-called agranulocytic angina; report of case, Arch. Int. Med., 1929, xlii, 533-548. CrossrefGoogle Scholar8 ROSENTHAL N: Hematological aspects of agranulocytosis and other diseases accompanied by extreme leukopenia, Am. Jr. Clin. Path., 1931, i, 7-32. CrossrefGoogle Scholar9 JACKSONPARKERRINEHARTTAYLOR HFJFFH: Studies of the diseases of the lymphoid and myeloid tissues, VI. The treatment of malignant neutropenia with pentose nucleotides, Am. Jr. Med. Assoc., 1931, xcvii, 1436-1440. CrossrefGoogle Scholar10 MINOT GR: Diminished blood platelets and marrow insufficiency; a classification and differential diagnosis of purpura hemorrhagica, aplastic anemia and allied conditions. Arch. Int. Med., 1917, xix, 1062. CrossrefGoogle Scholar11 CABOT RC: A guide to the clinical examination of the blood for diagnostic purposes, 1909, William Wood & Co., New York, 106. Google Scholar12 CLOUGH PW: Diseases of the blood, 1929, Harper & Brothers, New York, 63. Google Scholar13 FRIEDEMANN U: Angina agranulocytotica, Ztschr. f. klin. Med., 1928, cviii, 54-66. Google Scholar14 BAUER J: Die konstitutionelle Disposition zu inneren Krankheiten, 1924, J. Springer, Berlin. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STACY R. METTIER, M.D., F.A.C.P.; HARVEY T. OLSAN, M.D.Affiliations: San Francisco, CaliforniaFrom the Department of Medicine, University of California Medical School, San Francisco.Presented at the San Francisco Meeting of the American College of Physicians, April 7, 1932. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDas Zentralnervensystem bei Krankheiten des BlutesFURTHER STUDIES ON GRANULOPENIA WITH A REPORT OF TWELVE CASES*STEWART R. ROBERTS, F.A.C.P., ROY R. KRACKEThe Mechanisms of Nephrosis in Sinusitis in Children. 1 January 1933Volume 6, Issue 7Page: 855-868KeywordsBacterial physiologyBone marrowNeutropeniaProtozoan infections ePublished: 1 December 2008 Issue Published: 1 January 1933 PDF downloadLoading ...