Long-Term Protection of Hepatitis B Vaccine: Lessons from Alaskan Experience after 15 Years
Authors: Ding-Shinn Chen
Journal: Annals of Internal Medicine (2005)

Editorials1 March 2005Long-Term Protection of Hepatitis B Vaccine: Lessons from Alaskan Experience after 15 YearsDing-Shinn Chen, MDDing-Shinn Chen, MDFrom National Taiwan University College of Medicine, Taipei 100, Taiwan.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-5-200503010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Hepatitis B virus (HBV) is highly infectious and causes serious health problems worldwide. Approximately one third of the world's population has been infected, and about 400 million people have become chronic carriers (1, 2). The infection results in a wide spectrum of liver diseases, ranging from hyperacute fulminant hepatitis to refractory hepatic cirrhosis and hepatocellular carcinoma (3-5). Infection that occurs at a young age frequently results in chronic carriage of the virus. In contrast, only a small proportion of patients become chronic carriers if they contract the infection in adolescence or adulthood. Once the infection becomes chronic, HBV or part ...References1. Margolis HS. Hepatitis B virus infection. Bull World Health Organ. 1998;76 Suppl 2 152-3. [PMID: 10063701] MedlineGoogle Scholar2. Kao JH, Chen DS. Global control of hepatitis B virus infection. Lancet Infect Dis. 2002;2:395-403. [PMID: 12127351] CrossrefMedlineGoogle Scholar3. Chen DS. From hepatitis to hepatoma: lessons from type B viral hepatitis. Science. 1993;262:369-70. [PMID: 8211155] CrossrefMedlineGoogle Scholar4. Lee WM. Hepatitis B virus infection. N Engl J Med. 1997;337:1733-45. [PMID: 9392700] CrossrefMedlineGoogle Scholar5. Ganem D, Prince AM. Hepatitis B virus infection—natural history and clinical consequences. N Engl J Med. 2004;350:1118-29. [PMID: 15014185] CrossrefMedlineGoogle Scholar6. Chen DS. Viral hepatitis in East Asia. J Formos Med Assoc. 1996;95:6-12. 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