tbuckley/cabot-search huggingface dataset:
Abstract 2205: A three-gene signature predicts esophageal squamous cell carcinoma prognosis
Authors: Huihui Cao, Enmin Li, Liyan Xu
Journal: Cancer Research (2014)

Abstract The 5-year survival rate of esophageal squamous cell carcinoma (ESCC) remains dismal despite improvements in treatments such as surgical resection and adjuvant chemoradiation, and current clinical staging approaches are limited in their ability to effectively stratify patients for treatment options. To improve the clinical risk assessment for ESCC patients, we developed an immunohistochemistry-based predictor model by evaluating the prognostic value of a three-gene signature, i.e. epidermal growth factor receptor, phosphorylated Specificity protein 1, and Fascin, which constitute a regulatory axis in ESCC cells as revealed by our previously study. The presence of this three-gene signature and the association with clinical outcomes were analyzed in 185 esophageal curative resection specimens (generation dataset), and the findings were validated using an independent cohort of 130 specimens (validation dataset). We revealed that the protein expression of this three-gene signature was highly predictive of ESCC survival in both generation and validation datasets (P=0.001). Regression analysis showed that this three-gene signature was an independently predictor of overall survival (hazard ratio=1.990 [95% CI, 1.256-3.154], P=0.003 in generation dataset; hazard ratio=2.358 [95% CI, 1.391-3.996], P=0.001 in validation dataset). Importantly, the predictive ability of the 3-gene signature was more robust than that of each individual factor. In conclusion, this immunohistochemistry-based molecular model accurately predicts ESCC patient survival, and thus could serve as a complement to current approached in clinical risk stratification. Note: This abstract was not presented at the meeting. Citation Format: Huihui Cao, Enmin Li, Liyan Xu. A three-gene signature predicts esophageal squamous cell carcinoma prognosis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2205. doi:10.1158/1538-7445.AM2014-2205
ETIOLOGY OF OROYA FEVER
Authors: Hideyo Noguchi, Telémaco S. Battistini
Journal: The Journal of Experimental Medicine (1926)

A pure culture of a microorganism resembling in morphology and pathogenic action Bartonella bacilliformis has been obtained from blood taken during life from a case of Oroya fever which ended fatally. The blood taken at Lima into citrate solution and transported to New York at refrigerator temperature yielded positive cultures 28 days after its withdrawal from the patient. The strain of Bartonella bacilliformis thus isolated grows well on the semisolid leptospira medium, and also on slant agar containing animal blood. The initial growth is not readily recognizable to the naked eye, but the presence of the organisms can be determined by means of the dark-field microscope and by Giemsa and Gram staining methods. No growth has been obtained on the more ordinary culture media. The organism is an obligate aerobe, is Gram-negative, and under certain cultural conditions motile. All the forms which have been described as occurring in human red corpuscles may be found in the cultures, and in addition many granular and coarsely irregular forms have been met with. The inoculation of cultures of Bartonella bacilliformis into Macacus rhesus produces infection and gives rise to effects which differ with the mode of inoculation. The intravenous injection of the culture into young macaques induces a prolonged irregularly remittent fever. The organism can be cultivated from the blood over a long period, and it has been detected within the red corpuscles of the monkeys, reproducing the precise appearances observed in human cases of Oroya fever. The intradermal injection of the culture into the eyebrow of young macaques gives rise to nodular formations rich in new blood vessels and showing the bacilliform organism within the endothelial cells. From the experimentally induced nodules cultures of the organism are readily recovered.
Decrease in two intestinal copper/zinc containing proteins with antioxidant function in inflammatory bowel disease.
Authors: T P Mulder, H W Verspaget, A R Janssens, P A de Bruin, A S Pena, C B Lamers
Journal: Gut (1991)

Oxygen derived radicals contribute to tissue injury in inflammatory bowel disease. We measured the content of superoxide dismutase and metallothionein (two endogenous copper and zinc containing proteins involved in radical scavenging) in intestinal resection specimens from 29 patients with Crohn9s disease and 12 patients with ulcerative colitis and compared the concentrations with those obtained in the normal mucosa of a control group of 18 patients with colorectal cancer. The superoxide dismutase content was similar in control mucosa and non-inflamed mucosa from patients with inflammatory bowel disease (mean (SEM) 2.13 (0.10) and 2.24 (0.10) mg/g protein, respectively) but was decreased in inflamed mucosa (1.87 (0.08) mg/g protein, p less than 0.005 v non-inflamed mucosa). The metallothionein content was decreased in non-inflamed inflammatory bowel disease mucosa compared with control mucosa (0.23 (0.03) and 0.36 (0.04) mg/g protein, respectively, p less than 0.02) and a further decrease was found in inflamed mucosa (0.17 (0.02) mg/g protein, p less than 0.001 v control mucosa). No differences were found between Crohn9s disease and ulcerative colitis and no significant effect of medication or tissue localisation was noted. These findings might indicate a decreased endogenous intestinal protection against oxygen derived radicals in inflammatory bowel disease which could contribute to the pathogenesis of the disease.
Anticoagulant Therapy in Acute Myocardial Infarction-Reply
Authors: Charles K. Friedberg
Journal: JAMA (1962)

To  Editor:—  Dr. Howie's attack against anticoagulants is irrelevant to my special communication toThe Journal, which was designed exclusively to criticize a specific publication by a group of Danish physicians. Dr. Howie has failed to take issue with  esential criticisms which I made of  Danish report: (1) The study was unsatisfactorily controlled, since treated and untreated patients were not chosen by random selection (alternate case method). (2) Thromboembolic complications,  prevention of which is  major objective of anticoagulant therapy, were significantly reduced, according to  authors' statistical analysis. Therefore, their conclusion that the use of anticoagulants in acute myocardial infarction should be abandoned is not justified.  The Danish report does not provide evidence to support Dr. Howie's conjecture that deaths from anticoagulants outweigh  benefits of reduction in thromboembolism. Neither does this report indicate an increased incidence of cardiac rupture in  anticoagulated group; in
Long-term intermittent intravenous insulin therapy and type 1 diabetes mellitus
Authors: T.T. Aoki, M.M. Benbarka, M.C. Okimura, M.A. Arcangeli, R.M. Walter, L.D. Wilson, M.P. Truong, A.R. Barber, L.F. Kumagai
Journal: The Lancet (1993)
INTERESTING STONE CASES.
Authors: D. M. B. THOM
Journal: JAMA (1897)

<h3>Case 192.</h3> —An Arab from the Plains, about 55 years of age, came to the hospital April 17, complaining of pain in urinating; had suffered for some time, as many scars of the hot iron over the region of the bladder testified. He was of good build, fairly nourished, but had a terrible dread of the knife, and would not listen to the operation by lithotomy. I explained to him that if the stone was sufficiently friable I could remove it without cutting, provided it was not too large to be grasped by the lithotrite. So on those conditions he became an inmate of the hospital, and the work of crushing began. The stone was found to be very large, but I was able to grasp and crush portions of it. After crushing as much as I thought advisable at one sitting, I proceeded to withdraw the lithotrite (Thompson's), which
An Improved Form of Pessary
Authors: C. Godson
Journal: BMJ (1876)

TilE influence of climate in the treatment of chest-disease is a question of such world-wide interest, and on which such a diversity of opinion exists, that data from various sources are desirable, in order that general principles may be cstablished.Dr. Theodore Villiams, in his Lettso- mian Lectures, published in the early numbers of the BRITISH MEDICAL JOURNXAL for this year, has summed up the whole question, and has given statistics showing the results of treatment by climate in various parts of the world, and of treatment by long sea-voyages.Personal experience of this latter method induces me to contribute a few notes on some points which have occurred to me whilst perusing the above- mentioned lectures.
Cimetidine: prophylaxis against upper gastrointestinal haemorrhage after renal transplantation.
Authors: R H Jones, C J Rudge, M Bewick, V Parsons, M J Weston
Journal: BMJ (1978)

The incidence of upper gastrointestinal haemorrhage within four months of renal transplantation was studied in two groups of patients. Thirty patients who received prophylactic cimetidine suffered no episodes of upper gastrointestinal haemorrhage, while six of the 33 patients who did not receive cimetidine suffered haemorrhages and one of them died as a result. The difference between the groups was significant. The results suggest that the prophylactic use of cimetidine in patients receiving renal transplants is worth while.
The Business and Professionalism of Medicine
Authors: George D. Lundberg
Journal: JAMA (1997)

<h3>Prologue: Crisis = Danger + Opportunity</h3> The conflict between business and professionalism described in the first issue of<i>JAMA</i>of the last decade of this millennium and republished on the next page does not apply only to individual physicians. It also applies to groups of physicians, health care organizations, and professional associations of physicians. The horrendous and well-publicized difficulty<sup>1-7</sup>the American Medical Association (AMA) got itself into by entering into and announcing on August 12, 1997, an exclusive trademark licensing agreement with Sunbeam Products Inc bears abundant testimony to the depth of conflict embodied in this tension between business and professionalism. In the aftermath of the AMA's wrenching public adversity, there is good news. We all know that a patient must trust his or her physician. We now also know that the American public needs and must trust the AMA. What else do they have in these days of massive commercialization of
SKIN REACTIONS IN ATOPTC ECZEMA.
Authors: R. H. MEARA
Journal: British Journal of Dermatology (1955)

Journal Article SKIN REACTIONS IN ATOPTC ECZEMA. Get access R. H. MEARA, M.B., M.R.C.P. R. H. MEARA, M.B., M.R.C.P. Registrar, St. John's Hospital for Diseases of the Skin, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 67, Issue 2, 1 February 1955, Pages 60–64, https://doi.org/10.1111/j.1365-2133.1955.tb12688.x Published: 01 February 1955
Endoscopic, ultrasonographic, and pathologic correlation of lymphocytic gastritis
Authors: N. Aggarwal, S. Kuan, K. Fasanella
Journal: Endoscopy (2013)

A 71-year-old woman presented with weight loss, postprandial epigastric pain, and mild chronic diarrhea. Computed tomography of the abdomen demonstrated mild antral wall thickening ([Fig. 1]). Subsequent upper endoscopy showed diffuse inflammation, friability, and nondistensibility of the distal stomach ([Fig. 2]), suspicious for linitis plastica or lymphoma. Histologic examination of biopsy samples of the stomach demonstrated dense lymphoplasmacytic infiltration of the lamina propria, as well as patchy neutrophilic infiltrate in an apparent ulcer bed ([Fig. 3]). Immunostaining was not suggestive of a monoclonal process, and there was no evidence of Helicobacter pylori (H. pylori) colonization. Biopsies of a normal-appearing duodenum demonstrated preserved villous architecture with prominent lymphocytic infiltrate. A 1-month follow-up esophagogastroduodenoscopy noted mild improvement, with jumbo forceps biopsies demonstrating prominent lymphoid follicles and negative immunostaining once again. The patient was referred to the university hospital for endoscopic ultrasound. Endoscopic evaluation showed edematous, erythematous, and friable mucosa throughout the stomach. The stomach distended normally with insufflation. The duodenum had a "scalloped" appearance suspicious for celiac disease. Sonographic imaging revealed diffuse wall thickening of the distal body and antrum of the stomach, which was free of folds ([Fig. 4]). The gastric wall measured up to 9 mm. Duodenal biopsies showed villous blunting, crypt hyperplasia, and increase in intraepithelial lymphocytes in the lamina propria, suspicious for celiac disease. Gastric biopsies demonstrated a dense infiltrate of lymphocytes in the lamina propria consistent with lymphocytic gastritis. The histology showed no evidence of H. pylori or lymphoma. The patient's antiendomysial and antigliadin antibodies were negative, but she had a low-normal quantitative IgA level and she was HLA-DQ8 positive.
Delivering person centred care in long term conditions
Authors: Simon Eaton, Sue Roberts, Bridget Turner
Journal: BMJ (2015)

Transforming care for people with long term conditions, including support for self management, requires comprehensive reform of health systems largely geared to provide acute care. <b>Simon Eaton</b>, <b>Sue Roberts</b>, and <b>Bridget Turner</b> explore the barriers to change, arguing that the success of new approaches will depend on whole system change and strong leadership
P888 USEFULNESS OF ELF, IP10, FIBROSCAN AND THEIR COMBINATIONS IN THE EARLY PREDICTION OF SEVERE HEPATITIS C RECURRENCE AFTER LIVER TRANSPLANTATION
Authors: G. Crespo, M. Gambato, O. Millán, G. Casals, P. Ruiz, X. Forns, M. Brunet, W. Jiménez, M. Navasa
Journal: Journal of Hepatology (2014)
Any Hypertension During Pregnancy Raises Risk for Several Chronic Diseases
Authors: Mike Mitka
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Idiopathic Pulmonary Hemosiderosis
Authors: Milton Wigod
Journal: New England Journal of Medicine (1955)

PULMONARY hemorrhage of unknown etiology is a rarely reported cause of childhood anemia. In this condition iron pigment from red-cell break-down is trapped by local histiocytes, resulting in brown induration of the lung. This disease, which is often not diagnosed during the lifetime of the patient, is known as idiopathic pulmonary hemosiderosis and has been well described by Wyllie et al.1 It either follows an insidious course, suggesting chronic anemia, or is marked by acute episodes of hemorrhage, with resulting pallor, fever, abdominal pain and vomiting. Physical examination of the chest in fully developed cases may be negative, but x-ray . . .
STATUS LYMPHATICUS IN RELATION TO GENERAL ANAESTHESIA
Authors: W. J. McCardie
Journal: BMJ (1908)

How often, In looking for the particular, is the general overlooked!Much as we know of the mechanism of death -under anaesthesia and the action of narcotics on special organs, the inflaence of the general condition of the patient on the course of anaesthesia is still obscure.We need to take a broad view of our patient's constitution.On this occasion I wish to bring to your notice a definite pathologfcal entity, known as the "status l1 mphaticus," or "status thymicus."HISTORY.According to Griffi hs, Plater, in 1614, called attention to the fact that the thymus was Enlarged in certain cases of sudden death.Later, In 1723, Bichat made the same obEervation, and Kopp, in 1829, associated enlarged thymus with laryngo spasm.Ftiedleben denied the then common assumption that an enlarged ihymus could cause death by compression of the air passages.The merit of havlng directed into the right path the investigation of many hitherto inexplicable cases of sudden death is undoubtedly due to Paltauf.Grawitz of Greilswald had previously noted the occurrence of the enlargement of the thymus gland in two sudden deaths, and had emphasized the possibility of a connexion between such enlargement and sudden death.Paltauf, in 1889 and 1890, was the first to collect a large number of cases of sudden death in adults, whicb, on pootmortemn examination, gave, in an extreme degree, charac- teristically similar proofs of the correctness of his theory.There was found an (nlargement of the tonsils, of the lymphatic gland system, of the follicles at the base of the tongue, of the spleen, and, lastly, an enlarged thfimus gland, which varied in stze In different subject'; In most cases also there was narrowing of the aorta.This combination of conditions the investigator called the " lymphatico-chlorotic constitul ion," and referred the sudden deaths of certain patients of this type to cardiac paralysis and acute heart dilatation, putting aside a theory advanced as to the possibility of mechanical interference by pressure of the enlarged tbymus on the circulatory and respiratory organs.Paltauf's first case was that of a girl, aged 9, who sat up in bed and died suddenly.He speaks of sudden death during bathing, etc. Nordmann and Recklinghausen recorded similar cases of young people who died suddenly during or after a cold bath, and in whom, p08t mortem, status lymphaticus was found.Accordlig to Laqueur, Pott saw death occur in eight children who suffered from spasm of the glottis after introduction of a tongue spatula, and was convinced that they did not die from suffocation but from cardiac paralysis, for airtificial respiration after the attack was useless.In other cases where autopsy took place a
Inapparent Congenital Cytomegalovirus Infection with Elevated Cord IgM Levels
Authors: David W. Reynolds, Sergio Stagno, K. Gayle Stubbs, Arthur J. Dahle, Mary M. Livingston, Samuel S. Saxon, Charles A. Alford
Journal: New England Journal of Medicine (1974)

A longitudinal clinical, virologic and immunologic study found 18 patients with inapparent congenital cytomegalovirus infection among 267 neonates with elevated umbilical-cord IgM levels. Virus excretion persisted in most patients through the third year of life, and the concomitant antigenic stimulation resulted in an accelerated development of immunoglobulins M and G and in continued complement-fixing antibody production in 14. Some degree of sensorineural hearing loss occurred in nine of 16 patients tested as compared with two of 12 controls, and, in four, an auditory handicap was either proved or considered likely. A trend toward subnormal intelligence was observed in the infected children, and two manifested definite mental and social disability. Cytomegalovirus infection probably has an important causal role in mild to moderate auditory and mental dysfunction in childhood. (N Engl J Med 290:291–296, 1974)
Randomized, double‐blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy
Authors: Don C. Rockey, John M. Vierling, Parvez Mantry, Marwan Ghabril, Robert S. Brown, Olga Alexeeva, Igor A. Zupanets, Vladimir Grinevich, Andrey Baranovsky, Larysa Dudar, Galyna Fadieienko, Nataliya Kharchenko, Iryna Klaryts'ka, Vyacheslav Morozov, Priya Grewal, Timothy Mccashland, K. Gautham Reddy, K. Rajender Reddy, Vasyl Syplyviy, Nathan M. Bass, Klara Dickinson, Catherine Norris, Dion Coakley, Masoud Mokhtarani, Bruce F. Scharschmidt, A. Ahmed, L. Balart, B. Berk, K. Brown, A. Frolov, C. Howell, O. Khrustalev, M. Lucey, B. Maliakkal, A. Mendoza, C. O'Brien, R. O'Shea, M. Porayko, V. Radchenko, R. Rahimi, N. Shah, K. Shetty, S. Sigal, G. Storozhakov, S. Zucker, H. Tobias, M. Voigt, S. Weinman, D. Wolf, K. Zhidkov, T. Zvyagintseva
Journal: Hepatology (2013)

Glycerol phenylbutyrate (GPB) lowers ammonia by providing an alternate pathway to urea for waste nitrogen excretion in the form of phenylacetyl glutamine, which is excreted in urine. This randomized, double-blind, placebo-controlled phase II trial enrolled 178 patients with cirrhosis, including 59 already taking rifaximin, who had experienced two or more hepatic encephalopathy (HE) events in the previous 6 months. The primary endpoint was the proportion of patients with HE events. Other endpoints included the time to first event, total number of events, HE hospitalizations, symptomatic days, and safety. GPB, at 6 mL orally twice-daily, significantly reduced the proportion of patients who experienced an HE event (21% versus 36%; P=0.02), time to first event (hazard ratio [HR]=0.56; P<0.05), as well as total events (35 versus 57; P=0.04), and was associated with fewer HE hospitalizations (13 versus 25; P=0.06). Among patients not on rifaximin at enrollment, GPB reduced the proportion of patients with an HE event (10% versus 32%; P<0.01), time to first event (HR=0.29; P<0.01), and total events (7 versus 31; P<0.01). Plasma ammonia was significantly lower in patients on GPB and correlated with HE events when measured either at baseline or during the study. A similar proportion of patients in the GPB (79%) and placebo groups (76%) experienced adverse events. GPB reduced HE events as well as ammonia in patients with cirrhosis and HE and its safety profile was similar to placebo. The findings implicate ammonia in the pathogenesis of HE and suggest that GPB has therapeutic potential in this population. (Clinicaltrials.gov, NCT00999167).
Atrial Septal Defect
Authors: S. GILBERT BLOUNT, HENRY SWAN, GOFFREDO GENSINI, MALCOLM C. MCCORD
Journal: Circulation (1954)

Complete surgical closure of an atrial septal defect was accomplished under direct vision in five patients. Postoperative catheterization studies demonstrated complete obliteration of the previously existing left-to-right shunt and a reduction of the pulmonary artery blood pressure in all patients. The clinical and hemodynamic status returned to normal limits with but few exceptions.
Leukotriene B4 fails to induce penetration of lymorphonuclear leukocytes into psoriatic lesions
Authors: A.M. LAMMERS, P.C.M. KERKHOF
Journal: British Journal of Dermatology (1987)

The intraepidermal accumulation of polymorphonuclear leukocytes following the epicutaneous application of leukotriene B4 (LTB4) was studied in lesional and clinically uninvolved skin of five patients with chronic stable plaque psoriasis. The lesions were found to be wholly unresponsive to LTB4, doses of 100 ng failing to produce either micropustules or exocytosis. This phenomenon was sharply localized; the response immediately adjacent to the lesion being identical to that in more distant uninvolved skin. We speculate that both the reduced response to LTB4 in the psoriatic patient and also the tolerance to LTB4 seen after repeated applications, result from the induction of a P450-linked hydroxylase.