tbuckley/cabot-search huggingface dataset:
Regulation of the differentiation of PC12 pheochromocytoma cells.
Authors: K Fujita, P Lazarovici, G Guroff
Journal: Environmental Health Perspectives (1989)

The PC12 clone, developed from a pheochromocytoma tumor of the rat adrenal medulla, has become a premiere model for the study of neuronal differentiation. When treated in culture with nanomolar concentrations of nerve growth factor, PC12 cells stop dividing, elaborate processes, become electrically excitable, and will make synapses with appropriate muscle cells in culture. The changes induced by nerve growth factor lead to cells that, by any number of criteria, resemble mature sympathetic neurons. These changes are accompanied by a series of biochemical alterations occurring in the membrane, the cytoplasm, and the nucleus of the cell. Some of these events are independent of changes in transcription, while others clearly involve changes in gene expression. A number of the alterations seen in the cells involve increases or decreases in the phosphorylation of key cellular proteins. The information available thus far allows the construction of a hypothesis regarding the biochemical basis of PC12 differentiation.
COOPERATION TO REDUCE HOSPITAL BILLS BY MEDICAL AND ADMINISTRATIVE STAFFS
Authors: Albert W. Snoke
Journal: JAMA (1952)

<h3>To the Editor:</h3> —A comparison of hospital bills for the care of the same disease in 1939 and 1952 will make it obvious that hospitalization is expensive and becoming more so. While great advances have been made in medical and hospital care, there is growing concern that the patient's ability to pay for it is not keeping the pace. Are there ways to "ease the burden of cost" without adversely influencing the standard of care that must be maintained in the interest of the patient? If there are, the challenge should be accepted and shared by the entire hospital staff, administrative and medical alike. Serious consideration has been given to the solution of this problem and many constructive steps have been taken to reduce costs. Individual hospitals studying their various procedures have reported that hospital operation may be made more efficient through cooperative medical staff action. Important contributions to this
An Ergonomic Analysis of the Fulcrum Effect in the Acquisition of Endoscopic Skills
Authors: A. G. Gallagher, N. McClure, J. McGuigan, K. Ritchie, N. P. Sheehy
Journal: Endoscopy (1998)

Background: The loss of three-dimensional visual depth cues has been thought to be the main hindrance to the acquisition of endoscopic skills. However, the "fulcrum effect" of the abdominal wall on the manipulation of instruments has not to our knowledge been previously investigated.
Dieting and Exercise in Overweight, Lactating Women
Authors: Nancy F. Butte
Journal: New England Journal of Medicine (2000)

In this issue of the Journal, Lovelady et al.1 report the results of a 10-week intervention trial in which 40 overweight, lactating women were randomly assigned either to a diet-and-exercise group or to a control group at four weeks post partum. The goal was to determine whether restriction of energy intake compromised milk production and thereby the growth of the women's infants, and therefore whether such weight-loss programs are appropriate for overweight, lactating women soon after delivery. Lovelady et al. found that maternal loss of 0.5 kg of body weight per week did not affect the growth of the infants, . . .
Relationships between common polymorphisms of adenosine triphosphate–binding cassette transporter A1 and high-density lipoprotein cholesterol and coronary heart disease in a population with type 2 diabetes mellitus
Authors: Isabelle Porchay-Baldérelli, Franck Péan, Nathalie Emery, Suliya Maimaitiming, Naima Bellili, Florence Travert, Kamel Mohammedi, Ronan Roussel, Michel Marre, Frédéric Fumeron
Journal: Metabolism (2008)
Carpal tunnel syndrome and type of dialysis membrane.
Authors: J. Chanard, P. Bindi, S. Lavaud, O. Toupance, H. Maheut, F. Lacour
Journal: BMJ (1989)

1 Department of Health and Social Security. Disinfection of endoscopes potentially contaminated by mycobacterium species. Safety Infornation Bulletin 1986;28. 2 Working Party of British Society of Gastroenterologists. Cleaning and disinfection of equipment for gastrointestinal flexible endoscopy. Interim recommendations. Gut 1988;29:1134-51. 3 Centers for Disease Control. Recommendations for prevention of HIV transmission in health care settings. MMWR 1987;36:25. 4 Hanson PJV, Jeffries DJ, Batten JC, Collins JV. Infection control revisited: dilemma facing today's bronchoscopists. Br Med7 1988;297:185-7.
Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccine
Authors: Niels Hagenaars, Rolf J. Verheul, Imke Mooren, Pascal H.J.L.F de Jong, Enrico Mastrobattista, Harrie L. Glansbeek, Jacco G.M. Heldens, Han van den Bosch, Wim E. Hennink, Wim Jiskoot
Journal: Journal of Controlled Release (2009)
Demographic and clinical characteristics of cutaneous lupus erythematosus at a paediatric dermatology referral centre
Authors: B.Z. Dickey, K.E. Holland, B.A. Drolet, S.S. Galbraith, V.B. Lyon, D.H. Siegel, Y.E. Chiu
Journal: British Journal of Dermatology (2013)

Background Paediatric cutaneous lupus erythematosus (CLE) is uncommon and inadequately described in the literature. Similar to adults, children with CLE develop LE-specific and/or LE-nonspecific skin findings. Similarities and differences in demographics and clinical course between paediatric and adult CLE have not been sufficiently described. Objectives To detail the demographic and clinical features of paediatric CLE and compare these findings with those reported in the adult literature. Methods A retrospective chart review was performed of 53 children seen in a paediatric dermatology clinic with cutaneous manifestations of LE. Results Patients presented with all five major subtypes of CLE, with some notable differences from adult CLE and previously published reports of paediatric CLE. Progression from discoid LE to systemic LE (SLE) did not occur in our cohort. Patients with subacute CLE were more likely than adults to have lesions below the waist as well as concomitant SLE. Sex distribution for CLE in our study was equal prior to puberty and female predominant in post-pubertal patients. Conclusions Children with CLE have variable clinical presentations and progression to SLE that may be different from adult disease. Specifically, children with acute and subacute CLE may be more likely than adults to have systemic disease; therefore, patients with these subtypes should be monitored closely for evidence of SLE. Study limitations included small patient numbers that may limit the ability to generalize these data and relatively short follow-up intervals.
Optimizing Pumped Insulin Delivery
Authors: Jay S Skyler, Deborah E Seigler, Michael L Reeves
Journal: Diabetes Care (1982)

The use of portable devices for the subcutaneous infusion of insulin may facilitate the attainment of improved glycemic control in selected patients with insulin-dependent diabetes mellitus. Successful use of a program of continuous subcutaneous insulin infusion requires patient cooperation and motivation, routine monitoring of glycemia, and attention to food intake and activity. This article describes an approach by which patients may optimize glycemic control utilizing a set of algorithms based on patientdetermined blood glucose measurements. The algorithms permit programing the insulin infusion device to achieve the desired control.
36P Automated Quantitative Her2 Assessment in Circulating Tumor Cells: Discrepancies with Primary Tumor in Neoadjuvant and Metastatic Trials
Authors: F. Bidard, S.T. Ligthart, T. Bachelot, S. Delaloge, E. Brain, M. Campone, P. Viens, J. Pierga, L.W.M.M. Terstappen
Journal: Annals of Oncology (2012)
CYCLOSPORINE NEPHROTOXICITY AND THE ROLE OF TRIPLE RENAL SCINTIGRAPHY
Authors: S. Dadparvar, F. Samimi, S. Ahn, J. Wang, K. M. Kapadia, M. M. Gillan, L. Krishna, W. J. Slizofski
Journal: Clinical Nuclear Medicine (1997)

Dadparvar, S.; Samimi, F.; Ahn, S.; Wang, J.; Kapadia, K. M.; Gillan, M. M.; Krishna, L.; Slizofski, W. J. Author Information
Pemphigus foliaceus: preferential binding of IgG1 and C3 at the upper epidermis
Authors: C. HERNANDEZ, M. AMAGAI, L.S. CHAN
Journal: British Journal of Dermatology (1997)

The immunopathological mechanism of pemphigus foliaceus acantholysis remains controversial. Previous workers have found that IgG autoantibodies are reactive with the epidermal surface and capable of blister induction. The presence of complement components in lesions also suggests their potential role in this disease. Complement participation, however, has not been clearly demonstrated. We describe a case of pemphigus foliaceus (PF) in a 58-year old woman which was confirmed by histopathological and immunopathological studies, and by ELISA assay on recombinant PF antigen. Unusual features of this case include the predominance of IgG1 anti-epithelial antibody in both the deposits and circulation, and the preferential binding of IgG and complement component 3 at the upper epidermis. We believe that this pattern of co-localized deposition suggests a location-specific, non-random complement activation.
Adding lisinopril to losartan increased hyperkalemia and acute kidney injury in type 2 diabetes and proteinuria
Authors: Catherine M. Clase, Johannes F.E. Mann
Journal: Annals of Internal Medicine (2014)

ACP Journal Club18 March 2014Adding lisinopril to losartan increased hyperkalemia and acute kidney injury in type 2 diabetes and proteinuriaCatherine M. Clase, MB, BChir, Johannes F.E. Mann, MDCatherine M. Clase, MB, BChirMcMaster University, Hamilton, Ontario, Canada (C.M.C., J.F.M.)Search for more papers by this author, Johannes F.E. Mann, MDMcMaster University, Hamilton, Ontario, Canada (C.M.C., J.F.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-160-6-201403180-02003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationFried LF, Emanuele N, Zhang JH, et al; VA NEPHRON-D Investigators. Combined angiotensin inhibition for the treatment of diabetic nephropathy. N Engl J Med. 2013;369:1892-903. https://pubmed.ncbi.nlm.nih.gov/24206457Clinical Impact RatingsGIM/FP/GP: Endocrinology: Nephrology: References1 Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med. 1993;329:1456-62. [PMID: 8413456] Google Scholar2 Kunz R, Friedrich C, Wolbers M, Mann JF. Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease. Ann Intern Med. 2008;148:30-48. [PMID: 17984482] Google Scholar3 Parving HH, Brenner BM, McMurray JJ, et al; ALTITUDE Investigators. Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med. 2012;367:2204-13. [PMID: 23121378] Google Scholar4 Makani H, Bangalore S, Desouza KA, Shah A, Messerli FH. Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials. BMJ. 2013;346:f360. [PMID: 23358488] Google Scholar5 Pergola PE, Raskin P, Toto RD, et al; BEAM Study Investigators. Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med. 2011;365:327-36. [PMID: 21699484] Google Scholar Author, Article, and Disclosure InformationAffiliations: McMaster University, Hamilton, Ontario, Canada (C.M.C., J.F.M.)This article was published at Annals.org on 4 March 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPotential Usefulness of Losartan as an Antifibrotic Agent and Adjunct to Platelet-Rich Plasma Therapy to Improve Muscle Healing and Cartilage Repair and Prevent Adhesion Formation 18 March 2014Volume 160, Issue 6Page: JC3KeywordsACE inhibitorsAcute renal failureCreatinineProteinuriaRenal failureRenal physiologySafetyType 2 diabetes ePublished: 18 March 2014 Issue Published: 18 March 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ichthyosiform dermatosis with superficial blister formation and peeling: Evidence for a desmosomal anomaly and altered epidermal vitamin A metabolism
Authors: B. Mevorah, D. Salomon, G. Siegenthaler, D. Hohl, M.L. Meier, J.H. Saurat, E. Frenk
Journal: Journal of the American Academy of Dermatology (1996)
Ultrasonic energy. Effects on vascular function and integrity.
Authors: T A Fischell, M A Abbas, G W Grant, R J Siegel
Journal: Circulation (1991)

BACKGROUND Ultrasonic energy transmitted via flexible wire probes provides a new means of ablating atherosclerotic plaque. We studied the effects of ultrasonic energy (20 kHz) delivered via a ball-tipped wire probe on arterial vasomotor behavior in rabbit thoracic aortas in a perfused whole-vessel model. METHODS AND RESULTS After precontraction with phenylephrine (10(-5) M) or KCl (60 mM), the effects of ultrasonic energy (0.7-5.5 W x 60 seconds, 42-330 J) on arterial vasomotor behavior were measured using long-axis ultrasonic vessel imaging of the proximal (ultrasonic probe-treated) and distal (untreated) control segments. The efficacy of plaque ablation at these same probe-tip power outputs was evaluated in atherosclerotic, human cadaver iliofemoral arteries. Ultrasonic energy caused dose (energy)-dependent relaxation in rabbit aortas after precontraction with phenylephrine in arteries with endothelium (n = 8) and without endothelium (n = 8) (p less than 0.001 versus ultrasound treated at power outputs of 2.9 and 5.5 W). There was no difference in the relaxation dose responses between endothelialized and endothelially denuded segments (p = NS). Ultrasonic energy also caused significant relaxation (67 +/- 8%) after voltage-dependent precontraction with 60 mM KCl. Temperature measurements revealed less than 1 degrees C warming of the vessel wall during as long as 2 minutes of treatment at a power output of 5.5 W. Pathological examination showed no smooth muscle injury at (moderate) power outputs that caused arterial relaxation. At probe-tip power outputs of 2.9-5.5 W, ultrasonic energy recanalized two of two totally occluded cadaveric iliofemoral vessel segments. The ultrasonic ablation catheter was also demonstrated to cause arterial relaxation in a recanalized canine femoral artery in vivo. CONCLUSIONS Ultrasonic energy delivered via a flexible-wire probe produces dose-dependent, endothelium-independent smooth muscle relaxation capable of reversing both receptor-mediated and voltage-dependent vasoconstriction in vitro. At moderate power outputs, this relaxation response does not appear to be due to thermal effects or irreversible smooth muscle cell injury. This vasorelaxant effect of ultrasonic energy is also apparent in vivo, at doses that effectively ablate atherosclerotic plaque, and may improve the safety of arterial recanalization using ultrasonic energy.
A RADID TEST FOR CEREBROSPINAL FLUID PROTEIN DETERMINATION
Authors: ERWIN M. JACOBS
Journal: American Journal of Psychiatry (1959)

A rapid, reliable method for gross determination of the spinal fluid protein has been described through the use of Albustix reagent strips. This is most helpful when only small quantities of fluid are obtainable or when laboratory facilities are not immediately available, and can also be used as a rapid check on determinations made by other methods.
Utility of Tc-99m Mebrofenin Scintigraphy in the Assessment of Infantile Jaundice
Authors: SIMONA BEN-HAIM, JAMES E. SEABOLD, SIMON C. S. KAO, JANN JOHNSON, DUC TRAN, BRUCE P. BROWN
Journal: Clinical Nuclear Medicine (1995)

Technetium-99m mebrofenin hepatobillary excretory patterns were assessed in 36 infants with hyperbilirubinemia. Phenobarbital was administered to 22 patients before imaging. Final diagnoses included: intrahepatic cholestasis (14 patients), neonatal hepatitis (nine patients), biliary atresia (eight patients), alpha-1-antitrypsin deficiency (two patients), Alagille's syndrome (two patients), and cystic fibrosis (one patient). No patient with biliary atresia showed bowel activity by 24 hours. Of the 28 infants without biliary atresia, 23 (82%) had bowel activity visualized by 6-8 hours and 26 (90%) had bowel activity by 24 hours. Two had no bowel activity at 24 hours: one had cystic fibrosis and one had neonatal hepatitis. Of the 26 patients with bowel visualization, the time to visualize bowel did not differ between patient groups with and without phenobarbital induction. All of the patients with hepatitis, including those with marked dysfunction, showed good hepatic uptake. Mebrofenin scintigraphy is an important imaging technique in the diagnostic evaluation of infants with hyperbilrubinemia. In addition to biliary atresia, intrahepatic cholestasis due to cystic fibrosis and severe neonatal hepatitis may also cause bowel nonvisualization up to 24 hours. The results of this study suggest phenobarbital induction may not be needed when Tc-99m mebrofenin scintigraphy is used for the assessment of infantile jaundice.
What Induces the Warm-Up Ischemia/Angina Phenomenon: Exercise or Myocardial Ischemia?
Authors: Peter Bogaty, Paul Poirier, Luce Boyer, Jean Jobin, Gilles R. Dagenais
Journal: Circulation (2003)

The relation of the warm-up ischemia phenomenon to the presence and intensity of initial myocardial ischemia is unclear. We sought to determine whether the warm-up ischemia phenomenon requires initial myocardial ischemia or can be induced by exercise without ischemia and whether there is a relation between the intensity of initial ischemia and the attenuation of ischemia on reexercise.Twelve subjects with exertional myocardial ischemia performed 2 exercise ECG tests (1 and 2) at a +/-10-minute interval on 3 occasions (A, B, C) 1 month apart. A1 and A2 were symptom-limited. B1 was kept as long as A1, but its intensity was held under the ischemic threshold (heart ratexsystolic pressure at 1-mm ST depression [STD]) noted at A1. B2 was symptom-limited. C1 was also kept as long as A1 but with an intensity adjusted to maintain one-half maximum STD of A1. C2 was symptom-limited. Exercise duration of A2, B2, and C2 increased similarly compared with A1 (P=0.009). However, the ischemic threshold (x10-3) increased at A2 (23.5+/-6.0) compared with A1 (20.3+/-4.8; P<0.0001) but not at B2 (19.8+/-5.0) or C2 (21.5+/-5.8). Similarly, maximum STD adjusted to the highest heart rate-systolic pressure product common to A1, A2, B2, and C2 decreased at A2 (1.4+/-0.7 mm) compared with A1 (2.5+/-0.9 mm; P<0.0001) but not at B2 (2.7+/-0.9 mm) or C2 (2.3+/-0.9 mm).Exercises under the ischemic threshold and of intermediate ischemic intensity increase short-term exercise capacity, but myocardial ischemia of more than moderate intensity is needed to induce the warm-up ischemia phenomenon.
Treatment of Resistant Acromegaly with a Long-Acting Somatostatin Analogue (SMS 201-995)
Authors: LUClNDA B. BARNARD
Journal: Annals of Internal Medicine (1986)

Six patients with resistant acromegaly were given a longacting somatostatin analogue (SMS 201-995) for 5 to 12 months. The clinical response was dramatic; relief of headache occurred within minutes of the injection. The mean 24-hour growth hormone levels fell acutely after the administration of 50 or 100 µg every 12 hours, especially in four patients with small tumors (p < 0.001). Dosages of up to 1500 µg/d were necessary to produce maximum lowering of growth hormone secretion in some patients. On long-term treatment, plasma somatomedin-C levels fell in all patients and became normal in four. Plasma immunoreactive levels of SMS 201-995 related inversely to growth hormone concentration: A reproducible threshold for growth hormone inhibition in five of the patients, ranging from 70 to 1200 pg/mL, was maintained for 6 to 8 hours after the injections. This somatostatin analogue is effective in the treatment of acromegaly, has no major side effects, and causes only transient changes in carbohydrate metabolism.
Phase I Study of Two Different Schedules of Bortezomib and Pemetrexed in Advanced Solid Tumors with Emphasis on Non-small Cell Lung Cancer
Authors: Angela M. Davies, Cheryl Ho, Alex S. Metzger, Laurel A. Beckett, Scott Christensen, Michael Tanaka, Primo N. Lara, Derick H. Lau, David R. Gandara
Journal: Journal of Thoracic Oncology (2007)
THE PREVALENCE OF AUTOIMMUNITY AND RELATIONSHIP TO CARDIAC STATUS IN PEDIATRIC MYOCARDITIS AND RECENT ONSET DILATED CARDIOMYOPATHY
Authors: Kathleen Simpson, Caroline K. Lee, Madeleine Cunningham, Catherine Simon, Jeffrey Delaney, Kent Ward, Alan Tong, Saar Danon, Charles Canter
Journal: Journal of the American College of Cardiology (2013)
Cytokeratin expression is reduced in glycogenotic clear hepatocytes but increased in ground-glass cells in chronic human and woodchuck hepadnaviral infection†
Authors: Qin Su, Heide Zerban, Gerd Otto, Peter Bannasch
Journal: Hepatology (1998)

Hepatocytes of normal adult liver express cytokeratins (CKs) 8/18, but bile duct cells additionally contain CK7/19. We have previously demonstrated the frequent occurrence of foci of altered hepatocytes in association with hepatic tumors in humans and provided evidence for a preneoplastic nature of the focal lesions. In this study, we investigated the CK expression in both the preneoplastic lesions and extrafocal parenchyma. Sixty-seven explanted livers with cirrhosis or advanced fibrosis harboring preneoplastic focal lesions, with or without hepatitis B virus (HBV) infection, as well as 9 livers with HBV-associated fulminant hepatitis, were studied for the expression of CK7/8/14/18/19. Five livers from woodchucks infected with the woodchuck hepatitis virus (WHV) were also investigated. Glycogenotic clear hepatocytes were negative or weakly positive for CK8/18, while amphophilic hepatocytes were strongly positive for these CKs, the changes being associated with marked reduction and increase, respectively, of highly organized membranous components in their cytoplasm. This allows the distinct recognition of the clear-cell and clear-cell-dominant preneoplastic lesions in the human and woodchuck livers. In ground-glass hepatocytes expressing viral antigens, an unusual accumulation of CK8/18 was observed, but there was no evidence of preferential necrosis of ground-glass hepatocytes. Many CK7- and CK19-positive ductular (oval) cells were found in extrafocal liver tissue, but only rarely were they present within focal lesions.
218 TRANSIENT ELASTOGRAPHY (FIBROSCAN) IN HEPATITIS C NATIVE LIVER VS. LIVER TRANSPLANT RECIPIENTS WITH RECURRENCE: DIAGNOSTIC PERFORMANCE AND PREDICTORS OF ADVANCED FIBROSIS
Authors: J.C. Marin-Gabriel, J.B. De-la-Cruz, M. Tocado, Y. Rodriguez Gil, M.L. Manzano Alonso, A. Martin Algibez, I. Fernandez Vazquez, J.C. Meneu-Diaz, F. Colina-Ruizdelgado, E. Moreno Gonzalez, J.A. Solis-Herruzo, G. Castellano-Tortajada
Journal: Journal of Hepatology (2008)