The Effect of an Antithyroid Drug on the Clinical Course of Malignant Hypertension
Authors: GEORGE A. PERERA
Journal: Annals of Internal Medicine (1961)

Article1 July 1961The Effect of an Antithyroid Drug on the Clinical Course of Malignant HypertensionGEORGE A. PERERA, M.D., F.A.C.P.GEORGE A. PERERA, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-1-29 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA number of reports have been made suggesting that antithyroid measures may suppress and that thyroid products may aggravate some of the effects of experimentally induced hypertension in animals (1-9). Some of these claim that the development or maintenance of an elevated blood pressure is modified, whereas others stress the influence of the thyroid on vascular pathology. It is accepted generally that surgical removal of the thyroid is without benefit in patients with primary hypertension, but at least one patient with advanced disease showed clinical improvement over a period of several months following thyroidectomy (10).Inasmuch as the accelerated (malignant)...References1. GLENNLASHER FEP: Effect of total thyroidectomy upon the production and maintenance of experimental hypertension. Proc. Soc. Exp. Biol. Med. 38: 158, 1938. CrossrefGoogle Scholar2. BRAUN-MENÉNDEZ E: Tiroides e hipertensíon nefrógena experimental. Rev. Soc. Argent. Biol. 30: 138, 1954. MedlineGoogle Scholar3. SALGADO E: Effect of thyroidectomy on hypertension, nephrosclerosis and cardiac lesions produced by desoxycorticosterone acetate (DCA) treatment in the rat. Endocrinology 55: 377, 1954. CrossrefMedlineGoogle Scholar4. MASSONCORCORANPAGE GMACIH: Effects of renin and thyroxine in rats treated with corticosteroids and in rats with regenerating adrenals. Endocrinology 61: 409, 1957. CrossrefMedlineGoogle Scholar5. CHAPPELRONAREVESZCAHILL CIGCJ: Effect of propylthiouracil on adrenal-regeneration hypertension in the rat. Proc. Soc. Exp. Biol. Med. 98: 23, 1958. CrossrefMedlineGoogle Scholar6. FREGLYHOOD MJCI: Physiologic and anatomic effects of propylthiouracil on normal and hypertensive rats. Circulat. Res. 7: 486, 1959. CrossrefMedlineGoogle Scholar7. MELBYSPINK JCWW: Enhancement of lethal action of endotoxin in mice by triiodothyronine. Proc. Soc. Exp. Biol. Med. 101: 546, 1959. CrossrefMedlineGoogle Scholar8. FREGLY MJ: Prevention of salt hypertension by propylthiouracil treatment in rats. Proc. Soc. Exp. Biol. Med. 102: 299, 1959. CrossrefMedlineGoogle Scholar9. FREGLYGENNAROOTIS MJJFAB: Effect of treatment with radioactive iodine and iodine-deficient diet on development and maintenance of renal hypertension in rats. Circulat. Res. 8: 749, 1960. CrossrefMedlineGoogle Scholar10. KOUNTZHEMPELMANN WBLH: Chromatrophic degeneration and rupture of the aorta following thyroidectomy in cases of hypertension. Amer. Heart J. 20: 599, 1940. CrossrefGoogle Scholar11. PERERA GA: The accelerated form of hypertension—a unique entity? Trans. Ass. Amer. Physicians 71: 62, 1958. MedlineGoogle Scholar12. MCMICHAELMURPHY JEA: Methonium treatment of severe and malignant hypertension. J. Chron. Dis. 1: 527, 1955. CrossrefMedlineGoogle Scholar13. SOKOLOWPERLOFF MD: Five year survival of consecutive patients with malignant hypertension treated with antihypertensive agents. Amer. J. Cardiol. 6: 858, 1960. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE A. PERERA, M.D., F.A.C.P.Affiliations: New York, N. Y.Received for publication April 12, 1961.From the Department of Medicine, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital, New York, N. Y.Supported in part through the generosity of the Albert H. and Jessie D. Wiggin Foundation.Requests for reprints should be addressed to George A. Perera, M.D., Presbyterian Hospital, 620 W. 168th St., New York 32, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySecretion of Thyroxine and Non-Thyroxine Iodine by the Normal Human Thyroid Gland. Influence of Carbimazole and Pharmacological Doses of IodideHeart and coronary artery disease in hypothyroidismCORONARY-ARTERY DISEASE IN HYPOTHYROIDISMRENAL HYPERTENSION IN RENIN DEPLETED RATSDrug-Induced Hepatic Injury During Methimazole TherapyNEW THOUGHTS ON HYPERTENSION 1 July 1961Volume 55, Issue 1 Page: 29-32 Keywords Blood pressure Drugs Hospital medicine Hypertension Primary hypertension Surgeons Thyroid Thyroidectomy ePublished: 1 December 2008 Issue Published: 1 July 1961 PDF downloadLoading ...