tbuckley/cabot-search huggingface dataset:
ON THE SURFACE COMPOSITION OF NORMAL AND SENSITIZED MAMMALIAN BLOOD CELLS
Authors: Stuart Mudd, Emily B. H. Mudd
Journal: The Journal of Experimental Medicine (1926)

The interfacial tension method has been applied to the study of the surface composition of mammalian blood cells and to certain other particles. Unsensitized erythrocytes and stromata possess only a small margin of stability in the interface and pass readily into the oil phase. Specifically sensitized erythrocytes and stromata possess much greater stability in the interface and pass into the oil only with considerable mechanical aid; characteristic deformations of the erythrocyte surface or the interface or both often result. With special immune sera prepared by Landsteiner and van der Scheer the quantitative relations are such as to indicate that the increased polarity of the sensitized erythrocyte surface is due to combination of the red cell surface lipoids with hemolytic sensitizer. These results are corroborative of the conclusion of Landsteiner and van der Scheer that erythrocytes contain specific lipoid-soluble antigens. The tentative conclusion is reached that with these anti horse-erythrocyte sera at least the agglutinins combine predominantly with the protein of the red cell surfaces. Fresh human leucocytes are spread and disintegrated by the interfacial stresses. After heat injury over the condenser with substage lamp the leucocytes typically do not enter the boundary surface. They are pushed before the advancing interface and, if their further advance is obstructed, bend the interface backward to form peninsulas and vacuoles. This change after heating is in the opposite sense to that to be expected from denaturation of the proteins of the protoplasm. Fresh oxalated rabbit platelets pass very easily into the oils. After heating over the substage lamp these elements also become less oil-miscible. The interfacial tension relations of blood cells, bacteria, and several cell products are tabulated.
PHOSPHORYLATED CARBOHYDRATE INTERMEDIATES OF THE HUMAN ERYTHROCYTE DURING STORAGE IN ACID CITRATE DEXTROSE. II. EFFECT OF THE ADDITION OF INOSINE LATE IN STORAGE*
Authors: Grant R. Bartlett, A. William Shafer
Journal: Journal of Clinical Investigation (1961)

Blood from a normal donor was drawn by gravity into ACD (NIH formula B) and stored at 40 C.After 21 days of storage, 100 ml of the ACD blood mixture was removed aseptically and to this was added inosine (4 mg per ml of blood) which had been autoclaved in normal saline in a concentration of 40 mg per ml.This sample
<i>DCTN1</i>Mutation Analysis in Families With Progressive Supranuclear Palsy–Like Phenotypes
Authors: Paola Caroppo, Isabelle Le Ber, Fabienne Clot, Sophie Rivaud-Péchoux, Agnès Camuzat, Anne De Septenville, Claire Boutoleau-Bretonnière, Vanessa Mourlon, Mathilde Sauvée, Thibaud Lebouvier, Anne-Marie Bonnet, Richard Levy, Martine Vercelletto, Alexis Brice
Journal: JAMA Neurology (2014)

Progressive supranuclear palsy (PSP) is usually sporadic, but few pedigrees with familial clustering of PSP-like phenotypes have been described. Occasionally, MAPT, C9ORF72, and TARDBP mutations have been identified.To analyze the DCTN1 gene in 19 families with a clinical phenotype of PSP (PSP-like phenotype).Sequencing of the DCTN1 gene in familial forms of PSP at a referral center among 21 patients with familial PSP-like phenotypes. In addition, 8 patients and relatives from a family carrying a DCTN1 mutation were evaluated.Identification of the DCTN1 mutation and clinical description of DCTN1 mutation carriers.We identified a DCTN1 mutation in a large family characterized by high intrafamilial clinical phenotype variability. Two patients had PSP-like phenotypes with dystonia, vertical gaze slowness, dysexecutive syndrome, predominant axial rigidity, and midbrain atrophy on brain magnetic resonance imaging. The other patients manifested Perry syndrome, isolated parkinsonism, or a predominant behavioral variant of frontotemporal dementia.Mutations of the DCTN1 gene have been previously associated with amyotrophic lateral sclerosis and with Perry syndrome, a rare autosomal dominant disorder characterized by weight loss, parkinsonism, central hypoventilation, and psychiatric disturbances. Our study demonstrates that DCTN1 mutations should be searched for in patients with clinical PSP-like phenotypes and a behavioral variant of frontotemporal dementia, especially when a familial history of dementia, psychiatric disturbances, associated parkinsonism, or an autosomal dominant disorder is present.
Mitral Insufficiency: A Clinical Reappraisal.
Authors: Arthur Selzer
Journal: Annals of Internal Medicine (1966)

s1 May 1966Mitral Insufficiency: A Clinical Reappraisal.Arthur Selzer, M.D., F.A.C.P.Arthur Selzer, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1156_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past decade a complete conceptual reorientation of mitral valve regurgitation has taken place. This change is largely due to wider opportunities of studying patients with mitral insufficiency by more precise methods, such as cardiac catheterization and angiocardiography and by the wide experience gained by direct inspection of the valves on the operating room table. As a consequence, the traditional rheumatic origin of pure mitral regurgitation (without mitral stenosis) has been shown to be less important than the nonrheumatic variety, which includes some "new" syndromes.This study was based on clinical, hemodynamic and pathological assessment of 120 cases of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1156-1157KeywordsAngiocardiographyCatheterizationHemodynamicsMitral insufficiencyMitral stenosis Issue Published: 1 May 1966 PDF DownloadLoading ...
The future of medicine
Authors: I Morrison, R Smith
Journal: BMJ (1994)

Next week the leaders of British doctors will meet to consider the future of medicine. The BMA, the General Medical Council, the royal colleges, and the departments of health will all be represented. This is the first time that these groups have met at such a summit conference since the Christchurch conference of 1961.1 That conference led to the present system of postgraduate education. Next week's meeting occurs against a background of falling morale and is a response to a request to doctors from Ken Calman, the chief medical officer of England.2 He asked us to look beyond the current turmoil in the NHS to consider the core values of medicine, and on p 1140 he sets out his vision of the future. One thing we know about the future is that it will be different from now. Doctors tired of change may long for a period of stability, but this will not happen.

We must applaud this gathering of the clans of British medicine because all the evidence suggests that groups that look to the future do much better than those that look mostly to the past, hankering for a golden age that probably never existed. The simple fact that these groups, which often disagree in public and in private, are trying to speak with one voice is also important (p 1144). It will be important for the clans to consider how the world will change around them, and this editorial looks at changes that are likely to come …
Abuse of Antibiotics
Authors: T. M. Tibbetts
Journal: BMJ (1956)

Unaccompanied children (also called unaccompanied minors) are children who have been separated from both parents and other relatives and are not being cared for by an adult who, by law or custom, is responsible for doing so. From 2010 to 2020, unaccompanied minors accounted on average for 15.4% of the total number of first-time asylum applicants aged less than 18 years in the UK. These young people risk their lives and undergo traumatic journeys in search of a better life. However, when they arrive in the UK, they are vulnerable to significant ongoing traumatic experiences. In this review, we look at the reasons young people are forced to flee their countries, how they make their journey, and the risks and dangers they face along the way. We examine safety and victimisation risks faced by children and young people after arrival in the UK, which mechanisms and processes exist to safeguard these individuals, and examine the data available on outcomes of unaccompanied asylum-seeking child (UASC. Finally, we share two case examples that represent both the strengths and weaknesses of existing processes for UASC.
The Preoperative and Postoperative Vectorcardiogrom in Tetralogy of Fallot
Authors: GEORGE H. KHOURY, JAMES W. DUSHANE, PATRICK A. ONGLEY
Journal: Circulation (1965)

The analysis and description of the preoperative and postoperative vectorcardiograms in tetralogy of Fallot are presented. The spatial orientation of the maximum QRS vectors to the right, anteriorly, and inferiorly in group I is indicative of right ventricular hypertrophy. In group II patients, the vectorcardiogram showed evidence of increased electrical activity of the left ventricle. Vectorcardiographic patterns of complete right bundle-branch block were noted in nine patients in group III.
Role of screening in prevention and treatment.
Authors: M Kane, M Alter, R Esteban, M Rizzetto
Journal: Gut (1993)

Since viral hepatitis may be the most common form of chronic viral disease in the world, strenuous attempts are being made to reduce the incidence. To achieve this, strategies are being developed by various national and international bodies involving both the immunisation and screening of certain groups of the population. These strategies are by no means universal, and the value of screening specific groups is the subject of much debate. This paper will address a number of the issues related specifically to the question of screening for hepatitis B virus and hepatitis C virus (HBV and HCV, respectively) namely (a) what is screening?; (b) why should we consider screening?; (c) who should we consider screening?; (d) what are the benefits and liabilities of screening?; (e) what constitutes an acceptable screening test?; (f) should we be screening for HBV or HCV?
Prevalence of Astigmatism in 6- to 72-Month-Old African American and Hispanic Children: The Multi-Ethnic Pediatric Eye Disease Study
Authors: Arezoo Fozailoff, Kristina Tarczy-Hornoch, Susan Cotter, Ge Wen, Jesse Lin, Mark Borchert, Stanley Azen, Rohit Varma
Journal: Ophthalmology (2010)
Atypical 11q deletions identified by array CGH may be missed by FISH panels for prognostic markers in chronic lymphocytic leukemia
Authors: S R Gunn, M K Hibbard, S H Ismail, M Lowery-Nordberg, C H M Mellink, D W Bahler, L V Abruzzo, E L Enriquez, M E Gorre, M S Mohammed, R S Robetorye
Journal: Leukemia (2009)
Adaptations of Muscle to Various Exercises
Authors: Edward E. Gordon
Journal: JAMA (1967)

In these days of interest in physical activity, isometric exercise, and fitness geared to the improvement of the human soma, if not the psyche, it is reasonable to expect certain basic cause-andeffect answers about these preoccupations. Yet it is uncertain, though plausible, that exercise is hygienic; and, if it is, it is even more uncertain how it works. Another fundamental question is the mechanism of the ergogenic effects of exercise. Obvious as it is at the gross level, many details remain obscure. Though maintenance of health through activity is important, it is this ergogenic aspect of exercise, the enhancement of work performance, that we wish to discuss. The idea that strength and hypertrophy together invariably result from strenuous exercise is firmly rooted in popular and medical thought. Physiologically, this dual effect is included in the general term, work-hypertrophy. Second, the assumption of interdependence of strength and hypertrophy also implies that
UK community groups reject mental health reforms
Authors: G. Yamey
Journal: BMJ (1999)

The government's green paper on reform of the 1983 Mental Health Act has been widely condemned by those who use mental health services, policymakers, and politicians, despite receiving guarded support from the Royal College of Psychiatrists.The paper proposes instituting a new process for ordering compulsory care and treatment and extending the use of compulsory orders into the community.An initial assessment process performed by two health professionals would last for seven days, and this could lead to an application to an independent reviewer for a 21 day "provisional order."If further compulsory treatment is proposed then cases must be submitted to a new mental disorder tribunal.The tribunal would be able to order compulsory treatment in hospital or the community.The report states: "We want the new Mental Health Act to bridge the
Cardiovascular and non-cardiovascular mortality in dialysis patients: where is the link?
Authors: Kitty J. Jager, Bengt Lindholm, David Goldsmith, Danilo Fliser, Andrzej Wiecek, Gultekin Suleymanlar, Alberto Ortiz, Ziad Massy, Alberto Martinez-Castelao, Rajiv Agarwal, Peter J. Blankestijn, Adrian Covic, Gerard London, Carmine Zoccali, Friedo W. Dekker
Journal: Kidney International Supplements (2011)
Impedance cardiograms reliably estimate beat-by-beat changes of left ventricular stroke volume in humans
Authors: T. J EBERT, D. L ECKBERG, G. M VETROVEC, M. J COWLEY
Journal: Cardiovascular Research (1984)

Linear regression was used to compare stroke volumes calculated from tetrapolar impedance cardiograms and simultaneous left ventriculograms in 14 patients undergoing diagnostic left heart catheterisation. We calculated three to five consecutive stroke volumes from each ventriculogram. Left ventricular stroke volumes estimated by the two methods correlated closely: the correlation coefficients from pairs of data obtained from individual patients ranged between 0.77 and 1.00 (average=0.91), and the correlation coefficient for pooled data (all pairs from all subjects) was 0.79 (p<0.001). Changes in left ventricular stroke volume measured with the two methods also correlated well (r=0.89 for pooled data, p<0.001). The results suggest that impedance cardiograms provide reliable estimates of changes of beat-by-beat left ventricular stroke volumes and reasonable estimates of absolute levels of beat-by-beat stroke volumes in humans.
TECHNIC OF NONSURGICAL DRAINAGE OF THE BILIARY TRACT
Authors: JOHN RUSSELL TWISS
Journal: JAMA (1933)

Recent developments in the study of biliary tract disease have given added importance to nonsurgical drainage of the biliary tract. This description of technic, based on the procedure described by Lyon<sup>1</sup>in 1923 and including recent improvements, is given because the drainage can have no diagnostic or therapeutic value unless it is properly performed. The method described has proved satisfactory in more than 3,000 drainages which have been done as part of the routine in the Medical and Surgical Gall Bladder Clinic of the New York Post-Graduate Hospital. In the performance of a drainage, the relaxation and comfort of the patient are important. A quiet room with not more than one patient gives best results. Reassurance on the part of the operator is helpful if the patient has not had the tube before. He is instructed to swallow the tip of the tube in the same way as food.
Gene Therapy for Myocardial Protection : Transfection of Donor Hearts With Heat Shock Protein 70 Gene Protects Cardiac Function Against Ischemia-Reperfusion Injury
Authors: J. Jayakumar, K. Suzuki, M. Khan, R. T. Smolenski, A. Farrell, N. Latif, O. Raisky, H. Abunasra, I. A. Sammut, B. Murtuza, M. Amrani, M. H. Yacoub
Journal: Circulation (2000)

Heat shock protein 70 (HSP70) gene transfection has been shown to enhance myocardial tolerance after normothermic ischemia-reperfusion. We investigated the effect of HSP70 gene transfection on mechanical and endothelial function in a protocol mimicking clinical heart preservation.Rat hearts were infused ex vivo with Hemagglutinating Virus of Japan-liposome complex containing HSP70 gene (HSP, n=8) or no gene (CON, n=8), and heterotopically transplanted into recipient rats. Four days after surgery, transfected hearts were perfused on a Langendorff apparatus for 45 minutes, arrested with St Thomas' No. 1 cardioplegia for 4 hours at 4 degrees C, and reperfused for 1 hour. Mechanical and endothelial function was studied before and after ischemia. Creatine kinase was measured in reperfusion effluent. Hearts underwent Western blotting and immunohistochemistry to confirm HSP70 overexpression. Postischemic recovery of mechanical function (% preischemic+/-SEM) was greater in HSP versus CON: Left ventricular developed pressure recovery was 76.7+/-3.9% versus 60. 5+/-3.1% (P:<0.05); dP/dtmax recovery was 79.4+/-4.9% versus 56. 2+/-3.2% (P:<0.05); dP/dtmin recovery was 74.8+/-4.6% versus 57. 3+/-3.6% (P:<0.05). Creatine kinase release was attenuated in HSP versus CON: 0.22+/-0.02 versus 0.32+/-0.04 IU/min/g wet wt. (P:<0. 05). Recovery of coronary flow was greater in HSP versus CON: 76. 5+/-3.8% versus 59.2+/-3.2% (P:<0.05). Recovery of coronary response to 5-hydroxytryptamine (5 x 10(-)(5) mol/L) was 55.6+/-4.7% versus 23. 9+/-3.2% (P:<0.05); recovery of coronary response to glyceryltrinitrate (15 mg/L) was not different between HSP and CON: 87.4+/-6.9% versus 84.3+/-5.8% (NS).In a clinically relevant donor heart preservation protocol, HSP70 gene transfection protects both mechanical and endothelial function.
Pseudopneumothorax: A Migratory Mirage
Authors: Robert E. Falcone
Journal: JAMA (1987)

To the Editor—  I recently saw a patient in consultation who presented with a perplexing combination of roentgenogram findings and a clinical diagnosis of migratory   Report of a Case.—  A 70-year-old woman with a long history of angina pectoris was brought to the emergency department complaining of left-sided chest pain, which was relieved by sublingual nitroglycerin. On examination, she appeared as a thin, anxious woman in no distress. Her blood pressure, pulse, and respiratory rate were normal. Breath sounds were symmetrical and normal. Heart tones were normal and the rate irregular. A portable chest roentgenogram disclosed what appeared to be a left-sided pneumothorax. Because this was not consistent with her clinical findings, the roentgenogram was repeated. This time the left-sided pneumothorax had disappeared, but a right-sided pneumothorax had developed! The Figure is a composite of the two portable chest roentgenograms, showing what appears to be a left-sided and a
Data Processing in Endoscopy
Authors: G. M. Sobala, A. T. R. Axon
Journal: Endoscopy (1992)

See also: Data Processing in Endoscopy: Endotorace, a New Software Program for Bronchoscopy ReportingEndoscopy 1994; 26(07): 631-631DOI: 10.1055/s-2007-1009056
Cost-Effectiveness of Second-Line Chemotherapy for Non-small Cell Lung Cancer: An Economic, Randomized, Prospective, Multicenter Phase III Trial Comparing Docetaxel and Pemetrexed: The GFPC 05-06 Study
Authors: Alain Vergnenegre, Romain Corre, Henri Berard, Dominique Paillotin, Cecile Dujon, Gilles Robinet, Jacky Crequit, Suzanna Bota, Pascal Thomas, Christos Chouaid
Journal: Journal of Thoracic Oncology (2010)
THE MUSCULAR ATTACHMENTS OF THE TONSIL
Authors: ROBERT H. FOWLER
Journal: JAMA (1928)

In the modern operation of enucleation of the tonsil, the surgeon finds it easy to strip the upper lobe from its bed, but he encounters an obscure mass of muscular tissue attached to the submerged surface of the tonsil at the junction (below its middle) of the upper and lower lobes. At this stage he imagines, as a rule, that he has encountered the superior constrictor, which is commonly assumed to be an immediate relation. He ceases dissection and arranges the snare around the lower part of the tonsil, trusting to the automatic action of the wire to complete the operation. The result is imperfect enucleation, for the caprice of the snare may leave muscle attached to the tonsil or it may cut through the lower lobe, leaving a portion in situ. We propose to show that the superior constrictor is not an immediate relation; that it has no direct
Interaction of polystyrene/ poly(γ-benzyl l-glutamate) and poly(methyl methacrylate)/ poly(γ-benzyl l-glutamate) block copolymers with plasma proteins and platelets
Authors: Akihisa Mori, Yoshihiro Ito, Masahiko Sisido, Yukio Imanishi
Journal: Biomaterials (1986)
Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: Assessment of response to methacholine and exercise challenge
Authors: Saba Samee, Talissa Altes, Patrick Powers, Eduard E. de Lange, Jack Knight-Scott, Gary Rakes, John P. Mugler III, Jonathan M. Ciambotti, Bennet A. Alford, James R. Brookeman, Thomas A.E. Platts-Mills
Journal: Journal of Allergy and Clinical Immunology (2003)
Diagnosis of ophthalmia neonatorum.
Authors: J Winceslaus, B T Goh, E M Dunlop, J Mantell, R M Woodland, T Forsey, J D Treharne
Journal: BMJ (1987)

Ninety consecutively seen babies with eye discharge in the first three weeks of life were examined. Four babies had "sticky eyes" with no evidence of ophthalmia and had uniformly negative cultures and test results for antichlamydial antibody; these babies were excluded. Of the 86 babies with ophthalmia neonatorum, Neisseria gonorrhoeae was isolated from eight, Chlamydia trachomatis from 44, other bacteria alone from 20, and 14 had negative cultures. Three babies with negative cultures had longstanding conjunctivitis and had been treated with chloramphenicol eye ointment; all had antichlamydial IgM antibodies, indicating that the conjunctivitis was chlamydial. Hence the total number of babies whose conjunctivitis was chlamydial was 47. The result of the Gram stained conjunctival smear correlated well with that of culture and final assessment by the microimmunofluorescence test, enabling an immediate presumptive diagnosis to be made of gonococcal, chlamydial, or bacterial conjunctivitis. Prompt and effective treatment of babies was started. Explanation to the mother and contact tracing were carried out when the confirmatory cultures and antibody tests were completed. The Gram stained conjunctival smear is a highly sensitive, specific, and predictive test for the aetiological agent of ophthalmia neonatorum. By virtue of its simplicity and rapidity the test may be useful in developing countries.
REPORT OF A CASE OF EPIDEMIC CEREBRO-SPINAL MENINGITIS WITH RECOVERY FOLLOWING LUMBAR PUNCTURE.
Authors: PETER BASSOE
Journal: JAMA (1898)

In theJournal of the American Medical Associationfor July 2, Dr. J. B. Herrick reports a case of cerebro-spinal meningitis, in the postmortem of which the diplococcus intracellularis meningitis of Weichselbaum was demonstrated in the meningeal exudate. From this fact and from the large number of cases of meningitis observed in Chicago during the last months, the Doctor concludes that we have to deal with a mild epidemic, although the micro-organism had never been demonstrated before, probably because a bacteriologic examination has been made in but very few cases. The following case further proves the existence of genuine epidemic meningitis in Chicago at the present time: The patient, a Russian laborer, 45 years old, previously in good health, was admitted to treatment under Prof. Geo. F. Butler in the Cook County Hospital, June 17, 1898. Five-days before admission he had been suddenly taken with vomiing and diarrhea, followed by