tbuckley/cabot-search huggingface dataset:
Addition of bevacizumab to chemotherapy in acute myeloid leukemia at older age: a randomized phase 2 trial of the Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON) and the Swiss Group for Clinical Cancer Research (SAKK)
Authors: Gert J. Ossenkoppele, Georg Stussi, Johan Maertens, Kees van Montfort, Bart J. Biemond, Dimitri Breems, August Ferrant, Carlos Graux, Georgine E. de Greef, C. J. M. Halkes, Mels Hoogendoorn, Rene M. Hollestein, Mojca Jongen-Lavrencic, Mark D. Levin, Arjan A. van de Loosdrecht, Marinus van Marwijk Kooij, Yvette van Norden, Thomas Pabst, Harry C. Schouten, Edo Vellenga, Gregor E. G. Verhoef, Okke de Weerdt, Pierre Wijermans, Jakob R. Passweg, Bob Löwenberg
Journal: Blood (2012)
LACK OF SPECIES SPECIFICITY OF ANTIBODY TO AN ENZYME
Authors: Alfred Jay Bollet, John S. Davis, John O. Hurt
Journal: The Journal of Experimental Medicine (1962)

Antibodies to crystalline bovine hepatic L-glutamic dehydrogenase were induced in rabbits. These antibodies inhibited the bovine glutamic dehydrogenase used as antigen, and also inhibited glutamic dehydrogenases from rat, rabbit, human, pigeon, and frog livers, as well as frog renal and muscle glutamic dehydrogenase. The antibody did not inhibit yeast glutamic dehydrogenase which differs from the animal enzymes in cofactor requirement. The kinetic characteristics of the inhibition of the bovine glutamic dehydrogenase indicate mixed competitive and non-competitive inhibition, suggesting reaction with multiple antigenic sites; the data indicate competitive inhibition of the enzyme from other species, suggesting reaction with the catalytic site.
SUPPORT FOR HERNIA, RELAXED SACRO-ILIAC LIGAMENTS AND VISCERAL PROPTOSIS
Authors: Edward J. Brown
Journal: JAMA (1923)

The great comfort I have experienced leads me to describe this support in the interest of the thousands of sufferers from hernia, relaxed sacro-iliac and visceral proptosis. I have worn hernial supports for thirty or more years with varying discomfort. About fifteen years ago, an orthopedic friend advised me to lie on a hard board for an attack of sacro-iliac lameness. After two hours I rebelled, went to my harness maker, and ordered a heavy surcingle of webbing 4 inches wide and three-sixteenth inch thick, fitted with straps and buckles one-half inch from the upper and lower edges. This was buckled tightly about my hips, and I then went about my business. For comfort and cleanliness I wore a double thickness of canton flannel underneath. This is 2 yards in length, which allows several thicknesses to be folded in front over the hernia, affording an extra protection from the pressure
Human Tumor Xenografts Recurring after Radiotherapy Are More Sensitive to Anti–Vascular Endothelial Growth Factor Receptor-2 Treatment than Treatment-Naive Tumors
Authors: Sergey V. Kozin, Frank Winkler, Igor Garkavtsev, Daniel J. Hicklin, Rakesh K. Jain, Yves Boucher
Journal: Cancer Research (2007)

Abstract The effects of antiangiogenic therapy on tumors relapsing after irradiation are not known. To this end, we irradiated human tumors growing s.c. in nude mice with a single dose of 20 or 30 Gy. Compared with primary (treatment-naive) xenografts, the growth rate of recurrent tumors was 1.6-fold slower, which is consistent with the known “tumor bed effect.” For similar size tumors, recurrences had fewer functional vessels, a reduced vessel coverage by perivascular cells, and were more necrotic. Placenta growth factor concentration was significantly lower in relapses, whereas vascular endothelial growth factor (VEGF) levels were similar between primary and recurrent tumors. On the other hand, fibrillar collagen deposition was significantly increased in recurrent tumors. This radiation-induced fibrosis was partially responsible for the slower growth of recurrences; the i.t. injection of collagenase increased the growth rate of tumor relapses without affecting primary tumor growth. The mouse-specific VEGF receptor 2–blocking antibody DC101 induced a 2.2-fold longer growth delay in recurrent tumors compared with treatment-naive tumors. DC101 significantly decreased the interstitial fluid pressure and did not change the functional vessel density and perivascular cell coverage in both tumor variants. Interestingly, DC101 induced a rapid (2 days after treatment initiation) and significant decrease in tumor cell proliferation in recurrent but not in primary tumors. Thus, our results show that the stromal compartment and the response to antiangionenic therapy of primary and in-field recurrent tumors are significantly different. Our findings suggest that antiangiogenic agents could be effective in the treatment of patients with relapses after radiotherapy. [Cancer Res 2007;67(11):5076–82]
GAS BACILLUS GANGRENE OF LUNG
Authors: Leland F. Glaser
Journal: JAMA (1941)

Gangrene of the lung is a rare condition when compared to the frequency of the pneumonias, pulmonary abscesses and infarctions. It is usually secondary to other lung infections but may develop without a definite precursor. Severe debility is almost invariably associated with the diffuse form of pulmonary gangrene such as follows diabetes mellitus, protracted fevers, carcinoma or tuberculosis. Lung abscesses or bronchiectatic cavities secondary to pressure rarely become gangrenous. Large septic infarcts mays quickly develop into gangrene. Likewise, pneumonic areas secondary to aspiration of infected material from the upper respiratory tract, such as occurs after anesthesia, may be the forerunner of gangrene.  Bacteria associated with pulmonary gangrene are usually of multiple types. Among the more commonly found organisms are Streptococcus pyogenes, staphylococci, pneumococci, fusiform bacilli and the Spirochete of Vincent. The association of pulmonary gangrene with extensive gas bacillus infection of the lungs is mentioned but little in the literature.
Foot Skin Ischaemia in Atherosclerotic Peripheral Vascular Disease
Authors: A. J. McEwan, C. G. Stalker, I. McA. Ledingham
Journal: BMJ (1970)

Hyperbaric oxygen and the vasodilating effect of tolazoline hydrochloride were used to investigate atherosclerotic ischaemia of the skin of the foot. Ischaemic feet were divided into two subgroups each with a foot blood flow significantly higher than normal and significantly different from each other. The high blood flow in the ischaemic feet appears to have been an attempt to meet a tissue oxygen need. In some instances this need seems to have been satisfied but without obvious benefit to the ischaemic or anoxic skin. It is suggested that a local rather than a regional blood flow insufficiency is the cause of skin lesions in peripheral vascular disease.
Primary hyperparathyroidism: the case for medical management.
Authors: W Van'T Hoff, F W Ballardie, E J Bicknell
Journal: BMJ (1983)

Thirty two patients with primary hyperparathyroidism were followed up medically for a mean of 4.2 years. One patient had an operation because of a rise in plasma calcium concentration. There was no significant change in the mean plasma calcium and creatinine concentrations or in blood pressure during the period of follow up. The progress of these patients who were managed medically was compared with that of a group of 60 patients who had had successful operations for primary hyperparathyroidism. There was no significant change in mean plasma creatinine concentration or in blood pressure in the group who had had operations during a mean follow up period of 5.9 years. The natural history of mild asymptomatic hyperparathyroidism is probably different from and better than that of the type of hyperparathyroidism that was usually seen before the advent of routine chemical screening. It is suggested that patients over the age of 60 with mild asymptomatic hyperparathyroidism, and perhaps even younger patients, may not require operation.
Apoptosis markers soluble Fas (sFas), Fas Ligand (FasL) and sFas/FasL ratio in patients with bacteremia: A prospective cohort study
Authors: Reetta Huttunen, Jaana Syrjänen, Risto Vuento, Janne Laine, Mikko Hurme, Janne Aittoniemi
Journal: Journal of Infection (2011)
Demographers Ponder the Aging of the Aged and Await Unprecedented Looming Elder Boom
Authors: Teri Randall
Journal: JAMA (1993)

THE UNITED STATES has long thought of itself as a nation of youth, and indeed, this country was founded by youth. In colonial times, the average age of the population was 16 years and most people never reached old age. Since then, life expectancy at birth has increased to 75 years. Yet given this potential for long life, youth has become an obsession. Americans idolize it, yearn impossibly for it, and discriminate in favor of it. But this nation is an aging society. The baby-boom generation (people born from 1945 to 1965), which constitutes one third of the US population, is advancing inevitably toward old age (Fig 1). And because of improvements in life expectancy, the elderly population is experiencing an explosive growth spurt that is unprecedented in history. The population group aged 65 years and older (with 31 million members) is now 10 times larger than it was in
Sexual Symptoms in Endocrine Diseases: Psychosomatic Perspectives
Authors: Giancarlo Balercia, Marco Boscaro, Francesco Lombardo, Eleonora Carosa, Andrea Lenzi, Emmanuele A. Jannini
Journal: Psychotherapy and Psychosomatics (2007)

&lt;i&gt;Background:&lt;/i&gt; Not only the most frequent causes of endocrine sexual dysfunction, such as hypogonadism and hyperprolactinemia, but almost all extragonadal endocrinopathies (hyper- and hypothyroidism, hyper- and hypocortisolism, steroidal secreting tumors, etc.) may have a greater or lesser effect on sexual function. &lt;i&gt;Methods:&lt;/i&gt; We analyzed scientific literature on the correlations between hormones and sexual behavior, analyzing the most important issue from a practical point of view. The aim of this review article was thus to summarize the sexual symptoms that may be observed with endocrine diseases. &lt;i&gt;Results:&lt;/i&gt; Hormones directly or indirectly regulate all human sexual functions (desire, erection/lubrication, ejaculation, orgasm). Some sexual symptoms may occur as a psychosomatic consequence of hormonal impairment. However, in other cases, endocrine failure may be generated by the psychosomatic involvement. &lt;i&gt;Conclusions:&lt;/i&gt; The endocrinologist, as an expert in body chemistry, is ideally positioned to identify and evaluate the full range of medical, physical, and psychiatric problems disrupting sexual function.
A PHYLOGENETIC STUDY OF INSANITY IN ITS UNDERLYING MORPHOLOGY
Authors: TRIGANT BURROW
Journal: JAMA (1933)

Following normal and traditional interpretations, it has ever been the position of psychiatry that mental disorders consist in a disagreement or disparity between a patient's ideas or mental content and the ideas or mental content of the so-called healthy persons about him. Experimentation, however, with the interreactions of individuals under conditions of laboratory control, indicates that the real disparity in these disorders is not located in this interideational sphere but that it represents a behavior distortion in the biology of man as a race. In the present discussion I shall briefly describe a trend of investigation which attempts to trace to its demonstrable source the essential nature of this biologic conflict or disparity as indicated on the basis of these experiments.1  In the domain of structural medicine, as we know, the physician does not treat the symptoms of a disease condition in his attempt to remedy the condition. It
Two New Approaches to Liver Transplantation: One Organ, Two Patients...
Authors: Beverly Merz
Journal: JAMA (1989)

DIVIDING a single liver among two pediatric patients may be one way to compensate for a shortage of donor organs for small children, according to a report presented at the recent annual meeting of the American Society of Transplant Surgeons in Chicago, Ill. Jean Emond, MD, of the University of Chicago reported that a team led by Cristolph Broelsch, MD, during the last 2 years had performed 10 procedures in which the donor liver was divided and grafted into two recipients. Emond said that during the period only one child died while waiting for a suitable organ. Broelsch is one of the pioneers in reducing adult livers for transplantation in pediatric patients. In the current series of operations he used the excised portion of the liver as a graft for a second patient. In theory, each of the organ's eight independent sections could function as a liver, but the team
733-3 Successful Transplantation of Myoblasts into Adult Porcine Myocardium: A Potential Method to Repair a Failing Heart
Authors: Frank W. Smart, William Claycomb, Joseph DelCarpio, Duane Smith, Hector O. Ventura, Mandeep R. Mehra, Dwight D. Stapleton, Helen DeGruiter, R. Wayne Barbee, Clifford H. Van Meter
Journal: Journal of the American College of Cardiology (1995)
Psychiatry Essentials for Primary Care
Authors: David S. Resch
Journal: Annals of Internal Medicine (2009)

Medical Writings: Book Notes3 March 2009Psychiatry Essentials for Primary CareDavid S. Resch, MDDavid S. Resch, MDFrom Southern Illinois University School of Medicine, Springfield, Illinois.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-5-200903030-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Schneider RK, Levenson JL. 274 pages. Philadelphia: American Coll of Physicians; 2008. $49.95. ISBN 9781930513716. Order at www.acponline.org.Field of medicine: Psychiatry.Format: Softcover book.Audience: Primary care providers in an ambulatory setting.Purpose: To provide a practical approach to the diagnosis and treatment of psychiatric disorders for primary health care providers.Content: Recognizing that diagnosis and management of psychiatric illness is increasingly moving into the primary care sector, this book equips the primary care provider with the basic knowledge to care for patients with these needs. The authors provide a succinct background of epidemiology and phenomenology of psychiatric illnesses. ... Author, Article, and Disclosure InformationAffiliations: From Southern Illinois University School of Medicine, Springfield, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 March 2009Volume 150, Issue 5Page: 364KeywordsEating disordersHealth care providersMood disordersObstetrics and gynecologyPatientsPrimary carePrimary care physiciansPsychiatry and mental healthResearch quality assessmentSoftware tools ePublished: 3 March 2009 Issue Published: 3 March 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SOME POINTS REGARDING THE ETIOLOGY AND TREATMENT OF POST-NASAL CATARRH, WITH REMARKS ON THE HYGIENE OF THE RESPIRATORY ORGANS.
Authors: W. FREUDENTHAL
Journal: JAMA (1895)

There exists for whole nations as well as for the single individual, health and disease, life and death. Both are never in perfectly normal conditions of their organic being; in both, out of<i>small</i>and<i>persistent</i>working noxious influences, lasting dispositions and stationary diseases are developed, which affect here single organs or systems and there a great many or the majority of a nation. And just as certain as deeper causes finally influence the whole body of the individual, making him a sickly type, so the noxious agents affecting a whole people can stamp upon it a more or less distinguishable type of peculiarity and susceptibility to sickness or infirmity. (Geigel.) There are some noxious causes which the writer believes prevail more in this country than elsewhere. The disease, which we shall discuss in this paper, is post-nasal catarrh with all its sequelæ. This disease is so frequent in this
Abstract 1302: Role of the low-affinity leukotriene B4 receptor BLT2 in VEGF-induced angiogenesis
Authors: Joe Y. Hong, Geun-Young Kim, Jae-Hong Kim
Journal: Cancer Research (2010)

Abstract The leukotriene B(4) (LTB(4)) receptor BLT2 is expressed in endothelium, but no clear physiological function for it has yet been identified, especially in vascular angiogenesis. The purpose of this study is to characterize the potential function of BLT2 in vascular endothelial growth factor (VEGF)-induced angiogenesis. VEGF significantly upregulates BLT2 expression in human umbilical vein endothelial cells (HUVECs), and BLT2 knockdown by siRNA or inhibition of BLT2 by a specific BLT2 antagonist LY255283 attenuates VEGF-induced angiogenesis, which was determined by its effect on the formation of tube-like structures and on transmigration. The role of BLT2 in VEGF-induced angiogenesis was more evident in vivo, where BLT2 inhibition by LY255283 almost completely blocked VEGF-induced vessel formation in Matrigel-plug assays. In addition, we found that VEGF upregulates synthesis of the BLT2 ligand, 12(S)-hydroxyeicosatetraenoic acid (HETE). siRNA knockdown of 12-lipoxygenase (12-LO) expression attenuates VEGF-induced angiogenesis in HUVECs, and the addition of 12(S)-HETE to the 12-LO knockdown-HUVECs restores VEGF-induced angiogenesis. The activation of BLT2 itself by either 12(S)-HETE or LTB(4) evoked significant angiogenic phenotypes, both in vitro and in vivo. Our findings indicate that BLT2 plays an essential role in mediating VEGF-induced angiogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1302.
Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-like Receptor-2
Authors: Thimoteus Speer, Lucia Rohrer, Przemyslaw Blyszczuk, Rukshana Shroff, Kira Kuschnerus, Nicolle Kränkel, Gabriela Kania, Stephen Zewinger, Alexander Akhmedov, Yi Shi, Tina Martin, Damir Perisa, Stephan Winnik, Maja F. Müller, Urban Sester, Gabriel Wernicke, Andreas Jung, Ursula Gutteck, Urs Eriksson, Jürgen Geisel, John Deanfield, Arnold von Eckardstein, Thomas F. Lüscher, Danilo Fliser, Ferdinand H. Bahlmann, Ulf Landmesser
Journal: Immunity (2013)
An Unusual Receptive Aphasia as a Manifestation of Temporal-Lobe Epilepsy
Authors: Alan Solomon
Journal: New England Journal of Medicine (1957)

A CAREFUL study of patients with epilepsy, particularly those with prolonged focal activity, may provide new insight into the organization of various complex cerebral activities. The following report is a study of a patient with temporal-lobe epilepsy who manifested an unusual receptive aphasia during some of his seizures. This case is reported because of its pertinence to the formation and mechanism of speech and its relation to the temporal lobe.Case ReportT.F., a 29-year-old married IBM operator, was admitted to the Durham, North Carolina, Veterans Administration Hospital on October 16, 1956, for control of epileptic seizures.The patient had . . .
Oral Candidiasis and the Acquired Immunodeficiency Syndrome
Authors: BARBARA ROMANOWSKI
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 September 1984Oral Candidiasis and the Acquired Immunodeficiency SyndromeBARBARA ROMANOWSKI, M.D., JONATHAN WEBER, M.B.BARBARA ROMANOWSKI, M.D.Search for more papers by this author, JONATHAN WEBER, M.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-3-400_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent emergence of the acquired immunodeficiency syndrome and attempts to identify simple screening tests have prompted suggestions for investigating asymptomatic patients at high risk. Possible screening tests include a full blood count with differential, to assess total lymphocyte numbers; estimation of T-lymphocyte subsets; qualitative assessment of lymphocyte function by proliferative studies; in-vivo testing of cutaneous delayed-type hypersensitivity; and various serum markers, particularly acid-labile interferon and beta-2 microglobulin. None of these tests are specific for the syndrome and many are expensive and time consuming.Candidal infection is almost universal in patients with the syndrome and in many...Reference1. WEBER J, CARMICHAEL D, and SAWYER N. Clinical aspects of AIDS in the United Kingdom. Br J Vener Dis. (In press). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BARBARA ROMANOWSKI, M.D.; JONATHAN WEBER, M.B.Affiliations: Praed Street Clinic St. Mary's Hospital London England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byORAL CANDIDOSISMorphotypes of oral isolates of Candida albicans from patients infected with the human immunodeficiency virusOral diseases in HIV-1 infectionAcquired Immunodeficiency SyndromeOral manifestations of HIV infection and their management. I. More common lesionsThe gastrointestinal manifestations of AIDSOral candidiasis and AIDSDermatologische Frühsymptome bei HIV-InfektionOral CandidiasisGastrointestinal Disease in AIDSCutaneous Manifestations of the Acquired Immunodeficiency SyndromeOral candidiasis: Forerunner of acquired immunodeficiency syndrome (AIDS)? 1 September 1984Volume 101, Issue 3Page: 400-401KeywordsAIDSBiomarkersBlood countsCandidiasisHypersensitivityInterferonsLymphocytesQualitative studies ePublished: 1 December 2008 Issue Published: 1 September 1984 PDF downloadLoading ...
RESULTS OF SIMULTANEOUS ABRUPT WITHDRAWAL OF ATARAXICS IN 500 CHRONIC PSYCHOTIC PATIENTS
Authors: L. N. JUDAH, Z. M. JOSEPHS, O. D. MURPHREE
Journal: American Journal of Psychiatry (1961)

It is our opinion that the sudden withdrawal of tranquilizers from chronic psychotics living in a protective and reasonably permissive ward atmosphere will do no apparent harm to their condition in the majority of patients for a period ranging up to 5 months. Withdrawal symptoms were few, mild, and easily controlled, and asocial conduct usually subsided readily when the drugs were readministered. Drug intake as measured by duration, or dosage, or type of drug does not seem to be a factor as to how long a case can remain off medication socially. Neither do diagnosis, or apparent duration of illness, or age, except that those within the geriatric period seemed to remain off medication for the 90-day period in somewhat larger percentage. The results of this experiment seem to confirm a 1954 study(2) by a group at this hospital which found that clinical response and the pattern of resistive isolation in the Lorr Scale were the main improvements to be expected following the use of chlorpromazine and reserpine–and the present authors feel that this may well be true of all tranquilizers on this type of patient.
Hyperbaric oxygen in crush syndrome
Authors: M. R Hamilton-Farrell, T. Sahni
Journal: BMJ (1994)

studies of smoking cessation smokers' activities in attempting to stop smoking should be measured in tandem with more conventional measures of the rate of cessation.4Attempts to stop are associated with the final goal of continuous abstinence.Changes in the number of attempts to stop may thus be more sensitive to intervention than the dichotomous outcome of smoking cessation.This is just one suggestion, and much work is required to validate any new outcome measures.'The results of Cupples and McKnight's study2 suggest, however, that careful consideration of appropriate outcomes is vital to improving our knowledge about how we should approach health promotion.