"Excess Lactate" and Anaerobiosis
Authors: ROBERT E. OLSON
Journal: Annals of Internal Medicine (1963)

Editorials1 December 1963"Excess Lactate" and AnaerobiosisROBERT E. OLSON, PH.D., M.D.ROBERT E. OLSON, PH.D., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-960 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHuckabee (1) has appraised anaerobic metabolism in whole animals and in intact organs by determining the ratio of lactate to pyruvate concentrations in plasma, and by calculating "excess lactate." Such "excess lactate'' has been used as an index of tissue hypoxia. That this approach has been popular is shown by the large number of papers currently appearing in the medical literature. Three papers in this issue of the ANNALS are examples of this trend.A review of the evolution of this idea and the assumptions on which it is based, has suggested to me that some caution should be exercised...References1. HUCKABEE WE: Relationships of pyruvate and lactate during anaerobic metabolism. I. Effects of infusion of pyruvate or glucose and of hyperventilation. J. Clin. Invest. 37: 244, 1958. CrossrefMedlineGoogle Scholar2. DIXONWEBB MEC: Enzymes, Academic Press, New York, 1958. Google Scholar3. BOXERDEVLIN GETM: Pathways of intracellular hydrogen transport. Science 134: 1495, 1961. CrossrefMedlineGoogle Scholar4. LIEBERDAVIDSON CSCS: Editorial: Some metabolic effects of ethyl alcohol. Amer. J. Med. 33: 319, 1962. CrossrefMedlineGoogle Scholar5. HUCKABEE WE: Abnormal resting blood lactate. I. The significance of hyperlactatemia in hospitalized patients. Amer. J. Med. 30: 833, 1961. CrossrefGoogle Scholar6. EWYPABICOMAHERMINTZ GARCJFDH: Lactic acidosis associated with phenformin therapy and localized tissue hypoxia: report of a case treated by hemodialysis. Ann. Intern. Med. 59: 878, 1963. LinkGoogle Scholar7. KRUGERSKILLMANHAMWIGRUBBSDANFORTH FATGGJRCN: The mechanism of action of hypoglycemic guanidine derivatives. Diabetes 9: 170, 1960. CrossrefMedlineGoogle Scholar8. HUCKABEE WE: Relationship of pyruvate and lactate during anaerobic metabolism. V: Coronary adequacy. Amer. J. Physiol. 200: 1169, 1961. CrossrefMedlineGoogle Scholar9. GOODALEOLSONHACKEL WTRED: The effects of fasting and diabetes mellitus on myocardial metabolism in man. Amer. J. Med. 27: 212, 1959. CrossrefMedlineGoogle Scholar10. HACKELGOODALE DBWT: Effects of hemorrhagic shock on the heart and circulation of intact dogs. Circulation 11: 628, 1955. CrossrefMedlineGoogle Scholar11. WILLIAMSONKREBS JRHA: Acetoacetate as fuel of respiration in the perfused rat heart. Biochem. J. 80: 540, 1961. CrossrefMedlineGoogle Scholar12. KRASNOWGORLIN NR: Myocardial lactate metabolism in coronary insufficiency. Ann. Intern. Med. 59: 781, 1963. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLe métabolisme du lactate: données élémentaires et variations sur le thèmeStudies with High and Low Erucic Acid Rapeseed Oil in ManLactic Acid Concentrations in Vitreous Humor: Their Use in Asphyxial Deaths in ChildrenSubstrate utilization in the myocardiumLactate metabolism as a prognostic index in unstable anginaEffects of exercise on young and adult cattle at low and high altitudeTherapeutic implications of myocardial lactate metabolism in patients considered candidates for emergency myocardial revascularizationMyocardial Ischemia: Detection and QuantitationDAVID D. WATERS, M.D., F.R.C.P.(C), F.A.C.C., JAMES S. FORRESTER, M.D., F.A.C.C.Coma diabeticumCyanide intoxication in Macaca mulattaCoronary perfusion and myocardial metabolisn during open-heart surgery in manClinical Evaluation of Blood Lactate Levels in Equine ColicLactic acidosis: An experimental modelEffects of glucose-insulin-potassium on myocardial substrate availability and utilization in stable coronary artery diseaseLactic acidosis and renal phosphoenolpyruvate carboxykinase activity during exerciseDrücke, Blutgase, pH, Lactat und Pyruvat im Pfortaderblut bei bauchoperierten Patienten während der ersten 9 TageEnergy metabolism of beating rat heart cell culturesOxygen tension in a capillary-tissue system subject to periodic occlusionLactic Acidosis in Pulmonary Edema due to Left Ventricular FailureMILFORD FULOP, MICHAEL HOROWITZ, M.D., ARNOLD ABERMAN, M.D., ERNST R. JAFFÉ, M.D.Compensatory mechanisms during graded myocardial ischemiaUntersuchungen über Verlauf und Bedeutung von Blutgaswerten, Lactat und Pyruvat bei Reanimation und SchockCoronary sinus lactate measurements in assessment of myocardial ischemiaMetabolic Activity in Human Skeletal Muscle Effect of Peripheral Arterial Insufficiency2,3-DIPHOSPHOGLYCERATE AND TISSUE OXYGENATION IN UNCONTROLLED DIABETES MELLITUSSerial Determinations of Blood Lactate in Respiratory Distress SyndromeNomograms for Estimation of Excess LactateOxygen Transport in ManMyocardial anaerobiosis in anemia in ur?mic manLactat- und Pyruvatverhalten im femoralvenösen Blut vor und nach gezieltem Training bei Okklusion der Arteria femoralisThe infusion of Ringer's lactate solution during shockThe Value of Lactate and Pyruvate Measurements in the Assessment of the Redox State of Free Nicotinamide-Adenine Dinucleotide in the Cytoplasm of Perfused Rat HeartLactate and Oxygen Debt: An IntroductionMyocardial metabolism in acute regional ischemiaExperimental and Clinical Studies on Lactate and Pyruvate as Indicators of the Severity of Acute Circulatory Failure (Shock)Cerebral Hemodynamics and Metabolism Following Experimental Head InjuryLactic acidosisEnzymatic Methods for Lactic and Pyruvic AcidsOxygen in Acute Myocardial InfarctionThe Post-transfusion Syndrome and CytomegalovirusDer Stoffwechsel des menschlichen Herzens unter dem Einfluß von InsulinSome Metabolic Changes Associated with Anesthesia and OperationMetabolism of the heart in health and disease. Part IIIMeasurement of blood lactate levels and excess lactate as indices of hypoxia during anaesthesiaCardiovascular problems and functional evaluation in rehabilitation of hemiplegic patientsBlood pyruvate and lactate during febrile human infectionsArterial Levels, Cardiac and Hepatic Arteriovenous Differences, Extraction Coefficients and Oxygen Extraction Ratios of Various Substrates in Normal, and in Acute and Chronic Alloxan-Diabetic DogsInfluence of Atropine on Arterial Oxygen Tension, Acid-Base Status and Tissue Hypoxia in the Conscious HorseZum Stoffwechsel des SkeletmuskelsRole of hypocapnia in the blood lactate accumulation during acute hypoxiaCoronary blood flow and myocardial metabolism in obstructive cardiomyopathyMyocardial metabolism in cardiac hypoxiaLactate-Pyruvate Ratio and its Relation to Oxygen Pressure in Arterial, Coronarvenous and Femoralvenous BloodNeuroendocrine and metabolic effects of general Anaesthesia during spontaneous breathing, controlled breathing, mild Hypoxia, and mild HypercarbiaCoronary heart diseaseCoronary Insufficiency: Relations Between Hemodynamic, Electrical, and Biochemical ParametersRegional differences of the lactate/pyruvate response to progressive arterial hypoxemia�ber den Einflu� des Sauerstoffmangels auf den Kohlenhydrat-, Fett-und Eiwei�stoffwechsel w�hrend der PostnatalperiodeLactate and Pyruvate in the Brain of Rats During HyperventilationTHE SIGNIFICANCE OF LACTICACIDEMIA IN THE SHOCK SYNDROME*Lactic Acid Metabolism in Hypertensive PatientsDie regionale Verteilung des Sauerstoffmangels im experimentellen h�morrhagischen SchockLactate/pyruvate ratio of umbilical vein blood**This work was performed at Yale University School of Medicine, Departments of Anesthesiology and Obstetrics, Grace–New Haven Community Hospital, during the course of a sabbatical leave.Umbilical vein blood biochemical data and neonatal conditionAcidosi latticaFresh water drowning at lowered body temperatureMaternal lactate, pyruvate, and excess lactate production during labor and deliveryLactate-Pyruvate Studies in Ischemic FeetThe Pathogenesis of Cardiac CachexiaAnaerobic metabolic responses to acute maximal exercise in male athletesExcess Lactate: An Index of Reversibility of Shock in Human Patients 1 December 1963Volume 59, Issue 6Page: 960-963KeywordsAttentionBlood plasmaHypoxiaLactatesPyruvate Issue Published: 1 December 1963 PDF DownloadLoading ...