tbuckley/cabot-search huggingface dataset:
Psychodynamic Mechanisms in Psychosomatic Symptom Formation
Authors: M. de M’Uzan
Journal: Psychotherapy and Psychosomatics (1974)

What appears to me as fundamental in the genesis of the psychosomatic symptom is that this genesis is linked to an original psychic structure totally opposed to that of the neuroses. This structure is characterized by a deficiency, more or less marked, of the phantasmic activities which no longer, or very imperfectly, fulfil their functions of elaboration and integration.
Genomic deletion of the whole IgH 3′ regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes
Authors: Christelle Vincent-Fabert, Rémi Fiancette, Eric Pinaud, Véronique Truffinet, Nadine Cogné, Michel Cogné, Yves Denizot
Journal: Blood (2010)
Pre-erythrocytic Stages of Human Malaria: Plasmodium Ovale
Authors: P. C. C. Garnham, R. S. Bray, W. Cooper, R. Lainson, F. I. Awad, J. Williamson
Journal: BMJ (1954)

EOSINOPHILIA1BRIILjSH 257 protein were present in the urine following the prostatectomy, no red cells were found.This and the manner in which the urinary abnormalities cleared up during the recovery period indicate that the iodism was accompanied by a moderately severe degree of an acute renal disturbance, part of a generalized allergic reaction. SummaryA case of iododerma, with striking facial lesions, is described.The patient was a severe asthmatic treated, inter alia, with potassium iodide.Hypersensibility to the iodine resulted in skin lesions, a marked eosinophi- lia, tachycardia, and proteinuria.Recovery followed the withdrawal of iodine and the administration of A.C.T.H.The mechanism of the intoxication is discussed with particular reference to the significance of the eosino- philia.A comment is made on the so-called "E.P. syndrome" and on the effect of A.C.T.H.
Group Interpersonal Psychotherapy for Depression in Rural Uganda
Authors: Paul Bolton, Judith Bass, Richard Neugebauer, Helen Verdeli, Kathleen F. Clougherty, Priya Wickramaratne, Liesbeth Speelman, Lincoln Ndogoni, Myrna Weissman
Journal: JAMA (2003)

Despite the importance of mental illness in Africa, few controlled intervention trials related to this problem have been published.To test the efficacy of group interpersonal psychotherapy in alleviating depression and dysfunction and to evaluate the feasibility of conducting controlled trials in Africa.For this cluster randomized, controlled clinical trial (February-June 2002), 30 villages in the Masaka and Rakai districts of rural Uganda were selected using a random procedure; 15 were then randomly assigned for studying men and 15 for women. In each village, adult men or women believed by themselves and other villagers to have depressionlike illness were interviewed using a locally adapted Hopkins Symptom Checklist and an instrument assessing function. Based on these interviews, lists were created for each village totaling 341 men and women who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for major depression or subsyndromal depression. Interviewers revisited them in order of decreasing symptom severity until they had 8 to 12 persons per village, totaling 284. Of these, 248 agreed to be in the trial and 9 refused; the remainder died or relocated. A total of 108 men and 116 women completed the study and were reinterviewed.Eight of the 15 male villages and 7 of the 15 female villages were randomly assigned to the intervention arm and the remainder to the control arm. The intervention villages received group interpersonal psychotherapy for depression as weekly 90-minute sessions for 16 weeks.Depression and dysfunction severity scores on scales adapted and validated for local use; proportion of persons meeting DSM-IV major depression diagnostic criteria.Mean reduction in depression severity was 17.47 points for intervention groups and 3.55 points for controls (P<.001). Mean reduction in dysfunction was 8.08 and 3.76 points, respectively (P<.001). After intervention, 6.5% and 54.7% of the intervention and control groups, respectively, met the criteria for major depression (P<.001) compared with 86% and 94%, respectively, prior to intervention (P =.04). The odds of postintervention depression among controls was 17.31 (95% confidence interval, 7.63-39.27) compared with the odds among intervention groups. Results from intention-to-treat analyses remained statistically significant.Group interpersonal psychotherapy was highly efficacious in reducing depression and dysfunction. A clinical trial proved feasible in the local setting. Both findings should encourage similar trials in similar settings in Africa and beyond.
Reply to Ola Bratt's Letter to the Editor re: Jean-Louis Campos-Fernandes, Laurence Bastien, Nathalie Nicolaiew, et al. Prostate Cancer Detection Rate in Patients with Repeated Extended 21-Sample Needle Biopsy. Eur Urol 2009;55:600–9
Authors: Guillaume Ploussard, Alexandre de la Taille
Journal: European Urology (2009)
Polychlorinated Biphenyls and Risk of Testicular Germ Cell Tumors
Authors: Katherine A. McGlynn, Sabah M. Quraishi, Barry I. Graubard, Jean-Philippe Weber, Mark V. Rubertone, Ralph L. Erickson
Journal: Cancer Research (2009)

Exposure to endocrine-disrupting chemicals, such as polychlorinated biphenyls (PCB), may alter hormonal balance and thereby increase risk of testicular germ cell tumors (TGCT). To study the relationship of PCBs to TGCT, prediagnostic serum samples from 736 cases and 913 controls in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants study were analyzed. Adjusted odds ratios and 95% confidence intervals were estimated using logistic regression. PCB levels were examined in association with all TGCT and, separately, with each histologic type (seminoma and nonseminoma). Risks associated with seven functional groupings of PCBs, as well as sum of PCBs, were also examined. There were significantly decreased risks of TGCT in association with eight PCBs (PCB-118, PCB-138, PCB-153, PCB-156, PCB-163, PCB-170, PCB-180, and PCB-187) and no association with the remaining three (PCB-99, PCB-101, and PCB-183). The same eight congeners were significantly associated with decreased risk of nonseminoma, whereas five (PCB-138, PCB-153, PCB-156, PCB-163, and PCB-170) were associated with decreased risk of seminoma. All functional groupings of PCBs were also associated with decreased risk of TGCT and of nonseminoma, whereas six of the seven functional groups were associated with decreased risk of seminoma. Sum of PCBs was significantly associated with decreased risk of TGCT (P(trend) = 0.006), nonseminoma (P(trend) = 0.007), and seminoma (P(trend) = 0.05). Overall, these data do not support the hypothesis that PCB exposure increases the risk of TGCT.
Isaac Josiah and William Mulford Hand
Authors: Thomas B. Cole
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A growing abdominal problem
Authors: K. Kulkarni, N. Lakhani, A. Cope, D. McGrath
Journal: BMJ (2013)

A 58 year old man with learning difficulties was referred to the on-call general surgical team with a four day history of progressive abdominal distension and constipation. He was a resident at a care home, and his carer reported that apart from “a bit of diarrhoea” he had not opened his bowels for the past few days. The patient himself reported progressive, colicky abdominal discomfort. There had been no nausea or vomiting, and he appeared otherwise systemically well. He had originally been eating small amounts but stated that “he wasn’t hungry anymore” so had not eaten for the past 24 hours. He was taking no prescribed drugs, had no other medical problems, and had normal mobility. This was the third time that he had presented with similar symptoms. 

On examination, he had a markedly distended abdomen that was diffusely tender, but without guarding, and resonant to percussion. Bowel sounds were hyperactive. He did not have a fever and other observations were within normal ranges. Given his presentation, a plain abdominal radiograph was obtained (fig 1⇓).





### 1 What is the diagnosis?

#### Short answer

Large bowel obstruction secondary to sigmoid volvulus—twisting of a bowel loop around its mesenteric attachment. Volvulus accounts for 5-8% of all bowel obstructions. Sigmoid volvulus is one of the most common types of colonic volvulus, making up 40-70% of all cases.

#### Long answer 

Large bowel obstruction secondary to sigmoid volvulus—twisting of a bowel loop around its mesenteric attachment (fig 2⇓). Volvulus accounts for 5-8% of all bowel obstructions. Sigmoid volvulus is one of the …
Drug discovery in renal disease—towards a more efficient framework
Authors: Toshio Miyata, Tsuyoshi Ando, Hisami Hiragi, Kanako Watanabe, Fumi Yamamoto, Douglas E. Vaughan, Tatsuo Kurokawa, Yoshiteru Oshima, Charles van Ypersele de Strihou, Masahiro Takeuchi
Journal: Nature Reviews Nephrology (2014)
Apoptosis in the Heart
Authors: Wilson S. Colucci
Journal: New England Journal of Medicine (1996)

Apoptosis (or programmed cell death) is a central feature of normal tissue development in the fetus and of cell replacement in certain adult tissues (e.g., the thymus).1 In contrast to necrosis (or accidental cell death), apoptosis is a tightly regulated series of energy-dependent molecular and biochemical events orchestrated by a genetic program. Cells undergoing apoptosis can be distinguished from those undergoing necrosis by several characteristic features, including blebbing of the cell membrane, a reduction in cell volume, and condensation of nuclear chromatin. In contrast to necrosis, apoptosis usually occurs in isolated cells without inflammation.For a single cell, the process . . .
123IAZA: IODOAZOMYCIN ARABINOSIDE. SYNTHESIS, PURIFICATION AND CLINICAL EVALUATION IN CANCER PATIENTS
Authors: J R Mercer, R C Urtasun, A J McEwan, M B Parliament, J D Chapman, None McEwan, R H Mannan, L I Wiebe
Journal: Clinical Nuclear Medicine (1991)

S of the Society of Nuclear Medicine in Canada and Prairie Provinces Chapter, SNM Conjoint Meeting: PDF Only
High local interleukin 5 production in granuloma faciale (eosinophilicum): role of clonally expanded skin-specific CD4+ cells
Authors: A. Gauger, C. Ronet, C. Schnopp, D. Abeck, R. Hein, F-M. Kohn, J. Ring, M. Ollert, M. Mempel
Journal: British Journal of Dermatology (2005)

Journal Article High local interleukin 5 production in granuloma faciale (eosinophilicum): role of clonally expanded skin‐specific CD4+ cells Get access A. Gauger, A. Gauger Department of Dermatology and Allergy Biederstein, Biedersteiner Str. 29, D‐80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar C. Ronet, C. Ronet Unité de Biologie Moléculaire du Gène, INSERM 277, Department of Immunology, Institut Pasteur, Paris, France Search for other works by this author on: Oxford Academic Google Scholar C. Schnopp, C. Schnopp Department of Dermatology and Allergy Biederstein, Biedersteiner Str. 29, D‐80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar D. Abeck, D. Abeck Department of Dermatology and Allergy Biederstein, Biedersteiner Str. 29, D‐80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar R. Hein, R. Hein Department of Dermatology and Allergy Biederstein, Biedersteiner Str. 29, D‐80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar F‐M. Köhn, F‐M. Köhn Department of Dermatology and Allergy Biederstein, Biedersteiner Str. 29, D‐80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar J. Ring, J. Ring Department of Dermatology and Allergy Biederstein, Biedersteiner Str. 29, D‐80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Ollert, M. Ollert Department of Dermatology and Allergy Biederstein, Biedersteiner Str. 29, D‐80802 Munich, GermanyClinical Research Division of Molecular and Clinical Allergotoxicology, Technical University Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Mempel M. Mempel Department of Dermatology and Allergy Biederstein, Biedersteiner Str. 29, D‐80802 Munich, GermanyClinical Research Division of Molecular and Clinical Allergotoxicology, Technical University Munich, Germany Martin Mempel. E‐mail: m.mempel@lrz.tum.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 2, 1 August 2005, Pages 454–457, https://doi.org/10.1111/j.1365-2133.2005.06752.x Published: 01 August 2005
A descriptive profile of age-specific knee extension flexion strength in elite junior tennis players
Authors: Todd S Ellenbecker, E Paul Roetert, Tetsuro Sueyoshi, Scott Riewald
Journal: British Journal of Sports Medicine (2007)

Tennis requires repetitive multidirectional movement patterns that can lead to lower extremity injury. Knowledge of population and age-specific strength parameters can be used during performance enhancement training and rehabilitation of tennis players.The purpose of this study was to generate population and age-specific descriptive profiles of concentric isokinetic knee extension and flexion strength in elite junior tennis players, and determine whether bilateral differences exist between extremities and across age ranges.A total of 103 elite male tennis players (mean (SD) 15.92 (2.14), range 11-21) and 53 female tennis players (mean (SD) 15.0 (2.30, range 11-21) were isokinetically tested on a Cybex 6000 isokinetic dynamometer at 180 and 300 degrees/s to assess bilateral concentric knee extension and flexion strength using a standard bilateral testing protocol.No significant bilateral difference between the dominant (racquet side) lower extremity and the contralateral non-dominant side were measured in lower extremity knee extension or flexion strength normalised to body weight, or in the hamstring quadriceps strength ratios in male and female subjects. Male subjects did show significant (p<0.001) increases in knee extension and flexion strength across the age ranges from 11-15 years of age to 16-21 years. Female subjects did not show any significant change in the normalised knee extension or flexion strength across age ranges. Hamstring/quadriceps strength ratios were bilaterally symmetric and remained clinically and statistically constant across age ranges for the male and female elite tennis players.Population and age-specific isokinetic descriptive data from elite tennis players can provide guidance in the development and monitoring of performance enhancement and rehabilitation programs for elite tennis players. The changes identified in normalised knee extension and flexion strength in elite male tennis players necessitate the use of population and age-specific descriptive data.
Type I C1 inhibitor deficiency with a small messenger RNA resulting from deletion of one exon.
Authors: T Ariga, T Igarashi, N Ramesh, R Parad, M Cicardi, A E Davis
Journal: Journal of Clinical Investigation (1989)

The molecular genetic basis of C1 inhibitor (C1 INH) deficiency in a patient with type I hereditary angioneurotic edema was studied. This patient was found to have an abnormally short C1 INH mRNA together with a normal message. Restriction fragment length polymorphism of the C1 INH gene was detected by Southern blot analysis of the patient's DNA after digestion with Pst I or Sac I, and hybridization with a full-length C1 INH cDNA. Hybridization of the same blot with three different fragments of the full-length cDNA suggested that exon VII and portions of both flanking introns were deleted in the C1 INH gene. Northern blot analysis of RNA from cultured monocytes, using a probe corresponding to exon VII, also indicated that the abnormal C1 INH mRNA had a deletion of these nucleotides. To confirm the hypothesis that the short C1 INH mRNA contained a deletion, the involved segment of the patient's C1 INH mRNA was amplified using the polymerase chain reaction (PCR). PCR amplification yielded two C1 INH DNA fragments of different lengths (380 and 160 bp). Southern blot and sequence analysis of both DNA fragments clearly revealed that the smaller 160-bp DNA was derived from the abnormal message and had a deletion of nucleotides corresponding to exon VII.
THE EFFECT OF INHALATION OF OXYGEN UPON THE HEMOGLOBIN.
Authors: GEORGE J. PRESTON
Journal: JAMA (1895)

Ever since the discovery of oxygen by Priestley in 1774, it has been used as a therapeutic agent. In fact, Priestley himself made a number of experiments upon animals with the gas, thus preparing the way for experiments upon the human subject. A few years after his discovery, Lavoiser and Spalanzani demonstrated the relationship of oxygen to atmospheric air, and showed in a rough way the changes it produced in the blood. These experiments were more physiological than therapeutical, but not long after this date, Caillens in 1783 employed oxygen therapeutically. Jurine of Geneva, and Chaptal of Montpellier, followed with reports of cases of phthisis benefited by its use. The report of Fucroy to the French Academy was very extreme, making as it did absurd claims for oxygen in the treatment of numerous diseases. Beddoes in 1789 made a number of important observations upon the physiologic action of oxygen, and
Critical analysis of the signal-averaged electrocardiogram. Improved identification of late potentials.
Authors: P Lander, E J Berbari, C V Rajagopalan, P Vatterott, R Lazzara
Journal: Circulation (1993)

BACKGROUND This study performed a critical analysis of signal-averaging methods. The objective was to optimize detection of late potentials. METHODS AND RESULTS We studied two patient populations: a low-arrhythmia-risk group with no evidence of heart disease and a group with clinically documented ventricular tachycardia (VT). Filtered QRS duration (QRSD) and terminal QRS amplitude (RMS40) were measured from the vector magnitude. A QRS duration based on the latest detectable ventricular activity in any of the three individual XYZ leads was also measured. Because of improved signal-to-noise ratio, both individual lead analysis and extended (600-versus 200-beat) averaging yielded significant changes in signal-averaged ECG parameters. Both approaches gave an increased sensitivity for VT identification. Sensitivity, specificity, and accuracy were evaluated as functions of critical values of QRSD and RMS40. RMS measurements in the terminal QRS, ranging from 20 to 100 msec and including RMS40, did not contribute to maximizing sensitivity and were highly correlated with QRSD. Our results from the low-arrhythmia-risk group suggest that age and sex should be considered in the definition of late potentials. CONCLUSIONS We propose a VT risk stratification scheme using signal-averaged ECG parameters obtained from both individual lead and vector magnitude analysis. This allows definition of four categories of VT risk derived statistically from the study data. This definition is based on combined measures of sensitivity, specificity, and negative and positive predictive value.
Formation and disappearance of pocked erythrocytes: Studies in human subjects and laboratory animals
Authors: George R. Buchanan, Christine A. Holtkamp, Jureta A. Horton
Journal: American Journal of Hematology (1987)

Abstract The pocked or “pitted” RBC count is being increasingly utilized as a test of splenic function. Since little is known about patterns of formation and removal of the characteristic organelles in the pocked RBC, we performed serial pocked RBC counts following splenectomy in six patients and in three animal species (dogs, rats, and rabbits). In the patients, pocked RBC counts began to rise within 1 week following splenectomy and reached a plateau (40‐60%) by 60‐100 days. Similar results were obtained following splenectomy of dogs, except that the plateau value was less. Pocked RBCs in splenectomized rats rose initially, but after the sixth week there was a progressive decline in their numbers; splenosis or accessory spleens were not visualized at autopsy. Rabbits had only a slight and inconsistent rise in pocked RBCs after splenectomy. When the rate of removal of pocked RBCs from the circulation was determined by transfusion of blood from splenectomized dogs in eusplenic animals, the pocked RBC count rapidly decreased within 3 to 6 hours. Pocked RBCs did not disappear when crosstransfused into a splenectomized recipient animal. Prior treatment of the recipient dog with either corticosteroids or vincristine did not affect the pattern of removal of pocked RBCs. We conclude that pocked RBCs rise slowly following splenectomy, disappear rapidly from the circulation in the presence of a normal spleen, and vary in pattern of rise and peak levels following splenectomy of different laboratory animals.
STRANGULATION FOLLOWING REDUCTION EN MASSE (LEFT INGUINAL HERNIA): LAPAROTOMY: RECOVERY
Authors: G. A. Harrison
Journal: BMJ (1917)

half of a Petri dish, x, anId the metal plate is pres3ed firmly down on to it, so tlhat the edge of the dish is securely embedde(d in the lower plasticiiie containinig trench.Extra plasticine is added all round up to the level of the dotted linle sliowvn in the dia'ram so as to make an absolutely air-tight lute.
Recent Advances in Rheumatic Diseases: The Connective Tissue Diseases Other Than Rheumatoid Arthritis—1970 and 1971
Authors: STANLEY L. WALLACE
Journal: Annals of Internal Medicine (1972)

The most significant developments of clinical and pathophysiological interest in the connective tissue diseases (other than rheumatoid arthritis) during 1970 and 1971 are reviewed, with discussion of possible roles of virus and immunologic abnormalities in the pathogeneses of systemic lupus erythematosus, polymyositis, and polyarteritis. Disturbances of the microvasculature seem to be characteristic of scleroderma. Criteria for classification of systemic lupus erythematosus and of polymyalgia rheumatica have been reported, as were studies of the epidemiology, natural history, and survivorship of patients with systemic lupus erythematosus, scleroderma, and polymyositis. Therapeutic emphases have been on the treatment of systemic lupus erythematosus, polymyositis, polyarteritis, and Wegener's granulomatosis with steroids and cytotoxic agents. Guidelines for the use of cytotoxic drugs in rheumatic diseases have been described.