tbuckley/cabot-search huggingface dataset:
A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children☆
Authors: Malin Fagerås Böttcher, Mounira Hmani-Aifa, Anna Lindström, Maria Christina Jenmalm, Xiao-Mei Mai, Lennart Nilsson, Helena Aniansson Zdolsek, Bengt Björkstén, Peter Söderkvist, Outi Vaarala
Journal: Journal of Allergy and Clinical Immunology (2004)
Estrogen inhibits the response-to-injury in a mouse carotid artery model.
Authors: T R Sullivan, R H Karas, M Aronovitz, G T Faller, J P Ziar, J J Smith, T F O'Donnell, M E Mendelsohn
Journal: Journal of Clinical Investigation (1995)

The atheroprotective effects of estrogen are well documented, but the mechanisms responsible for these effects are not well understood. To study the role of physiologic (nanomolar) estrogen levels on the arterial response-to-injury, we applied a mouse carotid artery injury model to ovariectomized C57BL/6J mice. Mice were treated with vehicle (-E2, n = 10) or 17 beta-estradiol (+E2, n = 10) for 7 d, subjected to unilateral carotid injury, and 14 d later contralateral (normal = NL) and injured carotids from -E2 and +E2 animals were pressure fixed, harvested, and analyzed by quantitative morphometry. E2 levels in +E2 mice were consistently in the nanomolar range (2.1-2.5 nM) at days 0, 7, and 14. At 14 d, measures of both intimal and medial area were markedly increased in the -E2 group: (-E2 vs NL, P < 0.05 for both), but were unchanged from normal levels in the +E2 group (+E2 vs NL, P = NS and +E2 vs -E2, P < 0.05 for both). Cellular proliferation, as assessed by bromodeoxyuridine (BrdU) labeling, was significantly increased over NL in the -E2 mice, but this increase was markedly attenuated in the estrogen replacement group (total BrdU positive cells/section: NL = 6.4 +/- 4.5; -E2 = 113 +/- 26, +E2 = 40 +/- 3.7; -E2 vs NL, P < 0.05; +E2 vs NL, P = NS; -E2 vs +E2, P < 0.05). These data (a) demonstrate significant suppression of the mouse carotid response-to-injury by physiologic levels of estrogen replacement; (b) support the utility of this model in the study of the biologic effects of estrogen on the vascular-injury response; and (c) suggest a direct effect of estrogen on vascular smooth muscle cell proliferation in injured vessels.
PRIMARY ACTINOMYCOSIS OF THE KIDNEY
Authors: DONALD P. ABBOTT
Journal: JAMA (1924)

This case is reported because primary actinomycosis of the kidney is rare. Mrs. H. L., white, a resident of Chicago for forty-three years, entered the Presbyterian Hospital, Jan. 6, 1922, because of pain above the "left hip" radiating into the left thigh; anorexia, and general weakness. The symptoms were of two or three months' duration. Since November, 1921, she had lost 46 pounds (21 kg.). The symptoms were becoming progressively worse. There was nothing in the previous history that had any bearing on the case. The patient was small, emaciated and anemic. The general examination was negative except for a mass which could be felt in the left hypochondrium. This mass could be felt as well in front as behind. It was hard, fairly regular in outline, fixed and somewhat tender. The muscles lying over the mass posteriorly were tense; apparently this was due to muscular defense. The temperature, reaching
Hunting the gowk?--Psychiatric community care in Scotland.
Authors: I Pullen
Journal: BMJ (1993)

The implementation of the community care changes throughout the United Kingdom from 1 April will mark the culmination of a series of major health and social care reforms. The avowed aims of achieving value for money and improved consumer choice through the introduction of competitive internal markets have yet to be tested. The political complexion of Scotland means that any proposed change to the NHS has tended to be greeted with a mixture of suspicion and resistance. As a result very few self governing trusts and fundholding general practices exist north of the border. And although Scotland has not had a wide reaching policy of moving psychiatric patients out of hospitals, community care for mentally ill people has advanced spontaneously.
Protein kinase C βII activation induces angiotensin converting enzyme expression in neonatal rat cardiomyocytes
Authors: Y Zhang
Journal: Cardiovascular Research (2002)

Members of the protein kinase C (PKC) family are important mediators of cell signaling underlying multiple aspects of myocardial function. Activation of the betaII isoform of PKC is thought to be involved in the development of congestive heart failure. To investigate the biological effect of PKC-betaII, we measured gene expression of angiotensin converting enzyme (ACE) and angiotensin II (AngII) receptors AT(1A) and AT(1B) in cardiomyocytes overexpressing PKC-betaII.An adenovirus construct expressing PKC-betaII was introduced into cultured neonatal rat ventricular myocytes (NRVMs). Western blot and in situ kinase assay was used to measure PKC-betaII level and activity in NRVMs. Real time quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis was used to measure the mRNA levels of several genes following PMA stimulation of either un-infected or ad-PKC-betaII infected cells.Our data show that activation of PKC-betaII in cardiomyocytes leads to elevated expression of angiotensin-converting enzyme (ACE) gene. Treatment of adeno-PKC-betaII infected cardiomyocytes with phorbol 12-myristate 13-acetate (PMA) resulted in an 8-fold increase of ACE mRNA expression, whereas ACE mRNA levels only increased around 2-fold in uninfected or adeno-GFP (green fluorescent protein) infected cardiomyocytes with similar PMA treatment. The induction of ACE mRNA was blocked by the PKC-beta-specific antagonist LY379196. No significant change of angiotensin II receptors AT1a and AT1b could be detected in the cardiomyocytes expressing PKC-betaII.These data indicate that ACE is a transcription target of PKC-betaII activation in cardiomyocytes, and also suggest a mechanism for the involvement of PKC in cardiac hypertrophy and fibrosis through increased activity of angiotensin converting enzyme in the myocardium.
Dissociation between the inotropic and systemic effects of the calcium promoter BAY y 5959 in patients with heart failure
Authors: Michel F. Rousseau, Pierre E. Massart, Christian van Eyll, Joan Etienne, Sylvie Ahn, Liviu Stoleru, Martín Bomemann, Hubert Pouleur
Journal: Journal of the American College of Cardiology (1996)
Childhood epidermolysis bullosa acquisita: a novel variant with reactivity to all three structural domains of type VII collagen
Authors: E. Schmidt, B. Hopfner, M. Chen, C. Kuhn, L. Weber, E-B. Brocker, L. Bruckner-Tuderman, D. Zillikens
Journal: British Journal of Dermatology (2002)

Journal Article Childhood epidermolysis bullosa acquisita: a novel variant with reactivity to all three structural domains of type VII collagen Get access E. Schmidt, E. Schmidt Department of Dermatology, University of Würzburg, Josef‐Schneider‐Str. 2, 97080 Würzburg, Germany Search for other works by this author on: Oxford Academic Google Scholar B. Höpfner, B. Höpfner Department of Dermatology, University of Münster, Münster, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Chen, M. Chen Division of Dermatology, LAC/USC Medical Center, Los Angeles, CA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar C. Kuhn, C. Kuhn Department of Dermatology, University of Ulm, Ulm, Germany Search for other works by this author on: Oxford Academic Google Scholar L. Weber, L. Weber Department of Dermatology, University of Ulm, Ulm, Germany Search for other works by this author on: Oxford Academic Google Scholar E‐B. Bröcker, E‐B. Bröcker Department of Dermatology, University of Würzburg, Josef‐Schneider‐Str. 2, 97080 Würzburg, Germany Search for other works by this author on: Oxford Academic Google Scholar L. Bruckner‐Tuderman, L. Bruckner‐Tuderman Department of Dermatology, University of Münster, Münster, Germany Search for other works by this author on: Oxford Academic Google Scholar D. Zillikens D. Zillikens Department of Dermatology, University of Würzburg, Josef‐Schneider‐Str. 2, 97080 Würzburg, Germany Dr Detlef Zillikens. E‐mail: zillikens‐d.derma@mail.uni‐wuerzburg.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 3, 1 September 2002, Pages 592–597, https://doi.org/10.1046/j.1365-2133.2002.04863.x Published: 01 September 2002 Article history Accepted: 18 February 2002 Published: 01 September 2002
Intracellular Clusterin Induces G2-M Phase Arrest and Cell Death in PC-3 Prostate Cancer Cells1
Authors: Maurizio Scaltriti, Anna Santamaria, Rosanna Paciucci, Saverio Bettuzzi
Journal: Cancer Research (2004)

Abstract Enhanced clusterin gene expression has been related frequently to organ remodeling, tissue involution, and cell death. Whether clusterin represents a leading cause or a consequence of apoptosis induction is still a matter of debate. Clusterin is known as an extracellular secreted glycoprotein in the mature form. However, truncated isoforms of the protein and nuclear localization of clusterin have been described recently in association to cell death. Here, we show the biological effects triggered in PC-3 androgen-independent prostate cancer cells by overexpression of an intracellular, not secreted form of clusterin (intracellular-clusterin). Transient transfection of PC-3 cells with intracellular-clusterin resulted in nuclear localization signal-independent massive nuclear localization of the protein leading to G2-M phase blockade followed by caspase-dependent apoptosis. Constitutive expression of intracellular-clusterin (pFLAG- intracellular-clusterin) in recombinant PC-3 cells caused clonogenic toxicity. The rare pFLAG-intracellular clusterin surviving clones showed inhibition of the proliferation rate and altered phenotype with impaired mitosis and endoreduplication. In these cells, caspase-independent cell death was induced. Impaired cell cycle progression in pFLAG-intracellular-clusterin clones was associated to arrest at the G2-M checkpoint by down-regulation of the mitotic complex cyclin B1/cyclin-dependent kinase 1. Intriguingly, intracellular-clusterin was localized exclusively in the cytoplasm in stably transfected cells, suggesting a negative correlation between nuclear clusterin accumulation and cell survival. These findings may possibly explain the conflicting results obtained in different laboratories, suggesting that clusterin might be a proapoptotic or a survival gene, also opening new perspectives for the characterization of androgen-independent and apoptosis-resistant prostate cancer cells.
THE PRODUCTION OF THYROIDITIS AND ANTIBODY FOLLOWING INJECTION OF UNALTERED THYROGLOBULIN WITHOUT ADJUVANT INTO RABBITS PREVIOUSLY STIMULATED WITH ALTERED THYROGLOBULIN
Authors: William O. Weigle
Journal: The Journal of Experimental Medicine (1965)

Injection of rabbits with arsanil-sulfanil-thyroglobulin without adjuvant resulted in the production of hemagglutinating and precipitating antibody to native thyroglobulin and thyroiditis. Following a latent period of 1 month, these same rabbits responded to an injection of native thyroglobulin with an increase in both circulating antibody to native thyroglobulin and severity and frequency of thyroid lesions. Some rabbits initially immunized with arsanil-sulfanil-thyroglobulin also responded to a second and third monthly injection of native thyroglobulin, but the response to the third injection was usually not as good as the response to the first injection. A few of the rabbits showed a transient production of 19S antibody after the injection of native thyroglobulin was initiated. Neither circulating antibody nor thyroiditis were ever observed in rabbits injected with only native thyroglobulin without adjuvant. The correlation of the thyroiditis with the presence or absence of circulating antibody was discussed. Following a latent period after injections of aqueous arsanil-sulfanil-thyroglobulin some rabbits made a response to their own thyroglobulin released from an autotransplant of thyroid tissue.
Travel-Associated Disease; Gastroenterological Problems from the Tropics
Authors: C. J Ellis
Journal: BMJ (1995)

Travel Associated Disease , Ed Gordon C Cook Royal College of Physicians, £00A3;15, pp 180 ISBN 1 86016 012 3

Gastroenterological Problems from the Tropics , Ed Gordon C Cook BMJ Publishing Group, £14.95, pp 146 ISBN 0 7279 0902 9

Acentury ago Patrick Manson pointed out that “rather more than one fifth of the medical graduates of Great Britain” were practising in warm climates yet there was no special instruction, undergraduate or postgraduate, in the diseases that they had to deal with.

Today a tiny minority of Britain's medical graduates practise …
PRISMA-Equity 2012 Extension: Reporting Guidelines for Systematic Reviews with a Focus on Health Equity
Authors: Vivian Welch, Mark Petticrew, Peter Tugwell, David Moher, Jennifer O'Neill, Elizabeth Waters, Howard White
Journal: PLoS Medicine (2012)

Vivian Welch and colleagues present consensus-based guidelines for reporting equity-focused systematic reviews, the PRISMA-Equity extension.
555 ALCOHOL WITHDRAWAL ALLEVIATES SUBCUTANEOUS ADIPOSE TISSUE INFLAMMATION IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
Authors: C.S. Voican, M. Njiké-Nakseu, H. Boujedidi, N. Barri-Ova, L. Bouchet-Delbos, H. Agostini, S. Maitre, S. Prévot, A.-M. Cassard-Doulcier, S. Naveau, G. Perlemuter
Journal: Journal of Hepatology (2013)
Flt3-dependent transformation by inactivating c-Cbl mutations in AML
Authors: Bülent Sargin, Chunaram Choudhary, Nicola Crosetto, Mirko H. H. Schmidt, Rebekka Grundler, Marion Rensinghoff, Christine Thiessen, Lara Tickenbrock, Joachim Schwäble, Christian Brandts, Benjamin August, Steffen Koschmieder, Srinivasa Rao Bandi, Justus Duyster, Wolfgang E. Berdel, Carsten Müller-Tidow, Ivan Dikic, Hubert Serve
Journal: Blood (2007)
Fetal growth in early pregnancy and risk of delivering low birth weight infant: prospective cohort study
Authors: Radek Bukowski, Gordon C S Smith, Fergal D Malone, Robert H Ball, David A Nyberg, Christine H Comstock, Gary D V Hankins, Richard L Berkowitz, Susan J Gross, Lorraine Dugoff, Sabrina D Craigo, Ilan E Timor-Tritsch, Stephen R Carr, Honor M Wolfe, Mary E D'Alton
Journal: BMJ (2007)

<b>Objective</b> To determine if first trimester fetal growth is associated with birth weight, duration of pregnancy, and the risk of delivering a small for gestational age infant. <b>Design</b> Prospective cohort study of 38 033 pregnancies between 1999 and 2003. <b>Setting</b> 15 centres representing major regions of the United States. <b>Participants</b> 976 women from the original cohort who conceived as the result of assisted reproductive technology, had a first trimester ultrasound measurement of fetal crown-rump length, and delivered live singleton infants without evidence of chromosomal or congenital abnormalities. First trimester growth was expressed as the difference between the observed and expected size of the fetus, expressed as equivalence to days of gestational age. <b>Main outcome measures</b> Birth weight, duration of pregnancy, and risk of delivering a small for gestational age infant. <b>Results</b> For each one day increase in the observed size of the fetus, birth weight increased by 28.2 (95% confidence interval 14.6 to 41.2) g. The association was substantially attenuated by adjustment for duration of pregnancy (adjusted coefficient 17.1 (6.6 to 27.5) g). Further adjustments for maternal characteristics and complications of pregnancy did not have a significant effect. The risk of delivering a small for gestational age infant decreased with increasing size in the first trimester (odds ratio for a one day increase 0.87, 0.81 to 0.94). The association was not materially affected by adjustment for maternal characteristics or complications of pregnancy. <b>Conclusion</b> Variation in birth weight may be determined, at least in part, by fetal growth in the first 12 weeks after conception through effects on timing of delivery and fetal growth velocity.
In-vitro Comparison of Erythromycin, Lincomycin, and Clindamycin
Authors: I. Phillips, R. Fernandes, C. Warren
Journal: BMJ (1970)

The in-vitro antibacterial activities of erythromycin, lincomycin, and clindamycin, a new derivative of lincomycin, were compared. Clindamycin was always more active than lincomycin, and was either as active as erythromycin or more so against betahaemolytic streptococci, Streptococcus viridans, Str. pneumoniae, and erythromycin-sensitive Staphylococcus aureus. It was also fully active against most erythromycin-resistant strains of Staph. aureus. On the other hand, it was somewhat less active than erythromycin against Haemophilus influenzae and considerably less active than erythromycin against Str. faecalis and Neisseria gonorrhoeae.Clinical trials seem to be justified in infections with sensitive organisms for which erythromycin might have been indicated.
Human Leukocyte Cyclic AMP and Cyclic GMP Levels during Chemotaxis in Delayed Type Hypersensitivity
Authors: A. Lerche, H. Bisgaard, J. Dahi. Christensen, J. Søndergaard
Journal: Allergy (1984)

Ten nickel-allergic patients and six healthy control subjects participated in a study of the morphology, kinetics and evolution of the cAMP and cGMP concentrations of migrated leukocytes, using an improved skin chamber technique. Also studied was the effect of nickel exposure in the chamber medium during development of an eczematous reaction in the nickel-allergic patients. Nickel exposure had a specific effect on the morphology, from the 24th hour to the end of the 48 h observation period, with a significant increase in the percentages of basophils, eosinophils and lymphocytes and a decrease of neutrophils. A significantly increased leukocyte migration rate (LMR) was observed from the 27th to 39th hour in six of the allergic patients exposed to nickel. There were no specific permanent changes in cAMP and cGMP concentrations during nickel exposure. The control chambers of the allergic patients and healthy controls had identical leukocyte morphology, LMR and leukocyte concentrations of cAMP and cGMP. However, no correlations were found between LMR, cAMP and cGMP in the eczema patients throughout the observation period.
Eyes run on light.
Authors: M J Gilkes
Journal: BMJ (1979)

A major series of articles on basic ophthalmology published recently in the BMJ1 displayed a lacuna on one particular topic, prompted, no doubt, by shortage of space. The nature of this lacuna may best be illustrated by a recent conversation I had with a registrar in ophthalmology. When I asked him what were the most important questions to ask when a patient complained of deficient or defective vision he gave several replies. Many had merit and included two responses which are almost universal from primary health care workers faced with a similar problem?namely, Have you had your eyes tested recently ? and Have you been to your optician recently ? When I suggested that there were only two correct questions?firstly, was it in fact correct that the individual could not read or see, and, secondly, were they using appropriate and adequate lighting?he answered, But, surely that is common sense ?
The First Line of Intra-abdominal Metastatic Attack: Breaching the Mesothelial Cell Layer
Authors: Hilary A. Kenny, Kristin M. Nieman, Anirban K. Mitra, Ernst Lengyel
Journal: Cancer Discovery (2011)

Abstract Iwanicki and colleagues reveal that ovarian cancer spheroids clear mesothelial cells which cover the surface of the abdominal cavity using myosin-generated force. Cancer Discovery; 1(2); 100–2. ©2011 AACR. Commentary on Iwanicki et al., p. 144
The 1962 Earthquake in Iran
Authors: Farrokh Saidi
Journal: New England Journal of Medicine (1963)

AT 10:51:57 p.m. local time (GMT 19:21:57) on September 1, 1962, a major earthquake shook the northwest corner of the Central Iranian Plateau. The area involved, some 23,000 square miles, or nearly three times the size of Massachusetts, is a triangle formed by the junction of the Elburz mountains and the western Zagros ranges. The epicenter of the earthquake, the point of its maximum impact, was located at longitude 49, latitude 35.7, and at an altitude of about 5000 feet above sea level, some 120 miles west of Tehran, the capital of Iran (Fig. 1). In Tehran itself, a city . . .
Exercise Testing in Nonatherosclerotic Heart Disease
Authors: Anthony P. Morise
Journal: Circulation (2011)

E xercise testing first appeared in the medical literature in 1938. 1 Since then, exercise testing has achieved an established place in the armamentarium of tests available to the physician for evaluating patients with known or suspected cardiac disease.In clinical practice, the application of exercise testing is often combined with cardiac imaging.This is reflected in recently available appropriate use criteria for myocardial perfusion imaging and stress echocardiography. 2,3However, exercise testing as a standalone test without imaging still has value in properly selected patients.The latest iteration of guidelines from the American College of Cardiology/American Heart Association (ACC/AHA) concerning exercise testing is dominated by diagnostic or prognostic assessments of atherosclerotic coronary artery disease applications. 4Less prominent are those applications that pertain to hypertrophic cardiomyopathy (HCM), valvular heart disease, and arrhythmias including pacemakers, all of which are the subject of this review.
Hypertriglyceridemia and Acute Pancreatitis
Authors: Michael J. Murphy, Xia Sheng, Thomas M. MacDonald, Li Wei
Journal: JAMA Internal Medicine (2012)

detect a difference in the time health care providers took to answer questions from APSO vs SOAP notes.Further studies are needed to determine whether these outpatient findings at one center can apply to another, or to inpatient or emergency department settings, or even to radiology and pathology reports.Readability of EHR notes will be increasingly important as more organizations adopt EHRs.This study demonstrates that a structural change in the health care provider EHR progress note, from SOAP to APSO format, is feasible and generally well received.
Critically III Cancer Patients: Benefit and Expense
Authors: Leona E. Markson
Journal: JAMA (1993)

To the Editor.  —Schapira et al 1 provided important information on the high costs per year of life gained for cancer patients who were admitted to an ICU. However, their findings leave us once again searching for a crystal ball to tell us for whom the bell will toll. The authors conclude that: Physicians who treat patients with neoplastic disease should discuss potential outcomes and the possibility of withdrawing life-supportive therapy if appropriate with the patient and family, so that a reasonable strategy can be agreed on before the initiation of therapy. However, determining when it is appropriate to withdraw life support and what is a reasonable strategy remains a problem.  The authors note that previous studies have shown that only 23.7% of cancer patients admitted to an ICU will be alive 6 months later. 2 These statistics do not sound all that grim to many cancer patients who have
1191 GS-5816, A SECOND GENERATION HCV NS5A INHIBITOR WITH POTENT ANTIVIRAL ACTIVITY, BROAD GENOTYPIC COVERAGE AND A HIGH RESISTANCE BARRIER
Authors: G. Cheng, M. Yu, B. Peng, Y.-J. Lee, A. Trejo-Martin, R. Gong, C. Bush, A. Worth, M. Nash, K. Chan, H. Yang, R. Beran, Y. Tian, J. Perry, J. Taylor, C. Yang, M. Paulson, W. Delaney, J.O. Link
Journal: Journal of Hepatology (2013)