tbuckley/cabot-search huggingface dataset:
Sarcoidosis and Autonomous Parathyroid Hyperplasia
Authors: Robert F. Bohnen
Journal: JAMA (1971)

A patient had corticosteroid-resistant hypercalcemia and nephrocalcinosis caused by sarcoidosis. Investigations suggested autonomous hyperfunction of the parathyroid glands, and at surgery hyperplasia was the only abnormality found, Sarcoidosis and hyperparathyroidism may coexist even in the absence of a parathyroid adenoma.
What to do about inner cities
Authors: W. Russell
Journal: BMJ (1982)

The problems of the inner cities, particularly London, where elderly general practitioners insist on carrying on too long, often singlehanded from inadequate premises, are well known.Professor Acheson has just met Mr Geoffrey Finsberg, the junior Health Minister, to discuss his as yet unimplemented report on the problem, and the Opposition, noting that so far the Government has done nothing about it, is beginning to pile on the pressure.It has, after all, been around for a while.Mr Roland Moyle, the former Labour Health Minister, has been hard at work putting down questions trying to elicit some response-so far with little result.He told me that it was difficult for young doctors to come to London to practise when they were in the prime of their practising life."There is no way we can force GPs to retire," he added."Acheson has come up with some suggestions as to how the situation might be remedied, but the Government have given no indication whether they approve or reject or accept with modification his report.It is about time they decided what they are going to do."If lack of cash was the obstacle, and this was the excuse ministers always used, then he believed that Mr Kenneth Clarke, the Health Minister, could reorder the DHSS priorities so that spending on inner London was given priority over that on the home counties."They have plenty of fat," he said.It is a point of view that Mr Clarke apparently shares.
THE ROLE OF THE SULPHONAMIDES IN DERMATOLOGY*
Authors: REGINALD HEATHCOTE
Journal: British Journal of Dermatology (1944)

Journal Article THE ROLE OF THE SULPHONAMIDES IN DERMATOLOGY Get access REGINALD HEATHCOTE, D.M., F.R.C.P. StA. REGINALD HEATHCOTE, D.M., F.R.C.P. StA. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 56, Issue 3-4, 1 March 1944, Pages 59–68, https://doi.org/10.1111/j.1365-2133.1944.tb10818.x Published: 01 March 1944
Testosterone replacement therapy and cardiovascular events
Authors: G. Hackett
Journal: BMJ (2014)

In February 2014, The BMJ published a personal view by Sidney Wolfe of Public Citizen—a US anti-pharmaceutical pressure group trying to obtain black box warnings for testosterone products.1 The article presented summaries from two recent papers that claimed increased cardiovascular risk with testosterone replacement therapy (TRT).2 3

In July 2014, the Food and Drug Administration published a detailed response …
A CASE OF IRITIS AND ONE OF CORNEAL ULCER CURED BY TONSILLECTOMY
Authors: Richard M. Nelson
Journal: JAMA (1923)

Mrs. M. D. S., aged 20, housewife, consulted me, June 8, 1922, for a corneal ulcer of the right eye complicated by severe iritis. Physical examination was negative except for the eye trouble and a bad chronic tonsillitis. The Wassermann blood tests and urinalysis were negative. In December, 1920, I had advised tonsillectomy for the chronic tonsillitis found then. At that time I also noted some faint corneal scars in the right eye, and learned that four years previously this patient had been many weeks under treatment for corneal ulcer. For three weeks the usual methods of treatment were tried, with little real improvement. Believing the tonsillitis to be the cause of the eye inflammation, I again urged operation. The tonsils, on removal, showed many crypts filled with cheesy and purulent material. Within twenty-four hours the pain, the photophobia and the ciliary congestion were all greatly lessened, and within a
The impact of age on a mitoxantrone-based tumor vaccine
Authors: Keven Stonewall, Cecilia Quintero, Andrew Zloza, Howard Kaufman, Carl Ruby
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Several chemotherapies, including the anthracycline analog mitoxantrone, are known to induce an immunogenic cell death in tumor cells that can produce a protective anti-tumor immune response in mice. Although the anti-tumor immune response mediated by mitoxantrone tumor cell death
Evidence that natural murine soluble interleukin 4 receptors may act as transport proteins.
Authors: R Fernandez-Botran, E S Vitetta
Journal: The Journal of Experimental Medicine (1991)

The present studies were undertaken to determine whether the interleukin 4 binding proteins (IL-4BPs) previously identified in the biological fluids of mice are soluble forms of IL-4Rs. We also studied the binding properties of IL-4BPs in order to gain insight into their physiological role in vivo. Affinity-purified IL-4BPs and recombinant soluble IL-4Rs generated similar one-dimensional (Cleveland) peptide maps after digestion with either Staphylococcus aureus V8 protease or trypsin, indicating structural similarities. Furthermore, a rat mAb directed against the murine IL-4Rs immunoprecipitated the IL-4BPs and completely inhibited binding of 125I-IL-4 to a purified preparation of IL-4BPs. Taken together these data indicate that the IL-4BPs are soluble IL-4Rs. At 4 degrees C the IL-4BPs competitively inhibited the binding of IL-4 to membrane IL-4Rs but their ability to prevent binding of IL-4 to cells at 37 degrees C, at the same concentrations, was significantly reduced. Kinetic binding studies of soluble IL-4BPs vs. membrane IL-4Rs disclosed important differences in their rates of dissociation from IL-4. Whereas dissociation at 4 degrees C was slow for both, dissociation of IL-4 from IL-BPs at 37 degrees C was considerably faster (t 1/2 of 2 min) than dissociation of IL-4 from membrane IL-4Rs (t 1/2 of approximately 69 min). Temperature-dependent changes in dissociation kinetics were reversible, and could not be accounted for by either inactivation of the IL-4BPs at 37 degrees C or receptor internalization. Additional experiments also demonstrated that when IL-4BPs bind to IL-4 at 37 degrees C, the IL-4/IL-4BPs complex can rapidly dissociate, allowing IL-4 to bind to membrane IL-4Rs. In addition, binding of IL-4 by the IL-4BPs protects IL-4 from proteolytic degradation. Taken together, these results suggest that the IL-4BPs are naturally occurring forms of soluble IL-4Rs and that some of their properties (fast dissociation kinetics and protection of IL-4 from proteolysis) are consistent with a potential role as carrier proteins for IL-4 in the circulation.
Amygdalin (Laetrile) Toxicity in Rodents
Authors: C. Chester Stock
Journal: JAMA (1979)

To the Editor.—  Janardan D. Khandekar, MD, and Harlan Edelman in their article, Studies of Amygdalin (Laetrile) Toxicity in Rodents (242:169, 1979), reported lethality in rats from intraperitoneal injections of 250, 500, and 750 mg/kg for five days. At the two highest doses, a large number of deaths occurred promptly after only one or two injections. The authors do not appear to have sought an explanation for the discrepancy between their results and those of at least two other laboratories. 1,2 Wodinsky and Swiniarski 1 gave Sprague Dawley rats 500 and 1,000 mg/kg of amygdalin on days 1, 3, and 6; the first deaths did not occur until days 9 and 10, when untreated controls also died as a result of the Walker 256 tumors they bore. In studies by my colleagues and me 2 in Walker 256 tumor-bearing Wistar CFN rats, it was possible to give 1,000 mg/kg of
Advice on Sterility
Authors: R. H. P. Hick
Journal: BMJ (1943)

<h3>ABSTRACT</h3> <h3>Introduction</h3> Popular media coverage, including of recent positive late stage clinical trials in depression and PTSD, and decriminalization initiatives, are transforming the public perception of psychedelics. However, little is known about levels of knowledge and personal use of psychedelic mushroom(s) (PM) among American adults. <h3>Methods</h3> We examined PM use and various measures of health status, quality of life and self-reported mental health outcome measures obtained through a national on-line, cross-sectional survey of adults with a demographic composition representative of the US adult population by region, gender, age, and race (weighted N = 251,297,495) from November 2020–March 2021. <h3>Results</h3> General mental health and well-being was a popular reason for PM use (63.6%). PM users were less likely to be overweight than non-users, but overall quality of life (VR-12) was lower for mental health (39.5 vs 45.5). PM users reported significantly higher levels of anxiety (GAD-7 scores of 9.6 vs 5.9) and depression (PHQ-9 scores of 11.2 vs 6.8). They were less likely to have health insurance [OR=0.50 (0.35-0.72)], but reported significantly more healthcare services utilization. <h3>Discussion and Conclusions</h3> There is a mismatch between our findings of an association between PM use and poor mental health outcomes, and current discourse on the positive health benefits of PM consumption. A significant number of Americans are already “self medicating” with PM and further research to understand the role of anecdotal knowledge and pseudoscientific information in PM uptake. There is an urgent need for a PM use-related national harm reduction strategy.
Smoking Habits of Massachusetts Physicians
Authors: Leonid S. Snegireff, Olive M. Lombard
Journal: New England Journal of Medicine (1959)

IN June, 1954, we reported the results of the first survey of the smoking habits of Massachusetts physicians1 who were polled in February of that year; later, a comparative study of smoking habits of such physicians,2 categorized by medical specialties, was similarly published. The present report summarizes the results of a resurvey made by questionnaire on March 9, 1959. It was deemed desirable to obtain an expression of opinion on the subject of education of youth to the potential dangers of smoking.Returns from the members of the Massachusetts Medical Society indicate that many have changed their personal smoking habits . . .
Assessment of cardiac risk 10 days after uncomplicated myocardial infarction.
Authors: V M Jelinek, I G McDonald, W F Ryan, R W Ziffer, A Clemens, J Gerloff
Journal: BMJ (1982)

A total of 188 patients with uncomplicated acute myocardial infarction (long-term Norris prognostic index 3.2) were rapidly mobilised, underwent a symptom-limited exercise test around the day of discharge from hospital (day 10), and returned to work at a median of six weeks after the acute event. The incidence of cardiac death six months, one year, and three years after infarction was 2.7%, 4.5%, and 7.3% respectively, and the corresponding figures for recurrent heart attacks were 3.4%, 8.2%, and 18.5% respectively. The risk of recurrence of heart attack was predicted by three variables assessed at discharge--namely, a history of classical effort angina (p less than 0.01), radiological heart failure (p less than 0.05), and angina induced by the exercise test (p less than 0.05). The presence of any of these risk factors defined a group of patients with a sevenfold risk of recurrent heart attacks within six months of the initial acute infarct. It is concluded that these risk factors identify a group of patients with a high risk of recurrence early after infarction, in whom vigorous secondary prophylaxis is desirable.
Sectarianism and the Philadelphia County Medical Society.
Authors: Solomon Solis-Cohen
Journal: JAMA (1907)

Philadelphia, Oct. 28, 1907. <h3>To the Editor:</h3> —May I be permitted to correct the erroneous report of your Philadelphia correspondent (The Journal, October 26, page 1448) concerning the recent action of the Philadelphia County Medical Society in amending the section of its by-laws relating to qualifications for membership. On the blank form of applications for membership. On the blank form of application is printed the amendment as adopted. Your correspondent has omitted this very important proviso: <i>Provided</i>, (a) That all applicants for membership shall be required to state in writing that they do not accept any sectarian title or base their practice on any exclusive dogma or system: and (b) must satisfy the censors that they possess the requisite scientific and technical education and qualifications. Obviously your correspondent is in error in stating that "practitioners of all schools of medicine" will now be eligible for membership in the county society. On the contrary, any
Phenformin-Associated Lactic Acidosis: Pathogenesis and Treatment
Authors: ROBERT I. MISBIN
Journal: Annals of Internal Medicine (1977)

Since phenformin's introduction into clinical medicine, a total of 552 cases of lactic acidosis have been reported in patients taking this hypoglycemic agent. In 306 cases, sufficient documentation was available to establish the diagnosis with reasonable certainty (blood lactate, 6 meq/litre or greater, and blood pH, 7.33 or less). The mortality rate among insulin-treated patients (15%) was considerably less than the mortality rate in the group as a whole (42%). Taken together with results from animal studies, these data suggest that insulin is the treatment of choice for phenformin-associated lactic acidosis. Sodium bicarbonate should be administered to patients with severe acidosis, but should be withheld from patients with mild acidosis. Overly aggressive administration of sodium bicarbonate can be deleterious and should be avoided. Although dialysis has been suggested by some authors for the treatment of phenformin-associated lactic acidosis, the mortality rate among dialyzed patients (48%) was roughly the same as for the group as a whole (42%).
Cholesterol and coronary heart disease risk in elderly patients
Authors: T. Stamos
Journal: JAMA (1995)

<h3>To the Editor.</h3> —In an article in the November 2,1994, issue ofThe Journal, Dr Krumholz and colleagues<sup>1</sup>prospectively followed 997 elderly subjects and reported no significant relationship between total cholesterol or high-density lipoprotein cholesterol (HDL-C) and cardiac events. Because the wide confidence intervals (CIs) included values greater than 1.0, this cannot be considered a negative study. In fact, the upper limit of their CI for adjusted CHD mortality for men and women (1.98) is a similar risk ratio to that reported previously in middle-aged men.<sup>2</sup> Part of the reason for the wide CIs is likely the size of the study and short duration of follow-up. Studies establishing the relationship between hypercholesterolemia and CHD in middle-aged individuals evaluated many more subjects for greater lengths of time. For example, the Multiple Risk Factor Intervention Trial<sup>3</sup>(MRFIT) followed 356222 subjects over a 6-year period, and the Lipid Research Clinics
Abstract 1543: Tumor associated macrophages are associated with poor survival in epithelial ovarian cancer.
Authors: Wafic El Masri, Caroline Hillerup, Charlotte Topka, Chintda Santiskulvong, Alexander Chiang, Lily Wu, Jianyu Rao, Oliver Dorigo
Journal: Cancer Research (2013)

Abstract Background Tumor associated macrophages have been associated with poor outcomes in several solid tumors, but their impact on the outcome of patients with epithelial ovarian cancer has not been well established. Methods We constructed a tissue microarray of 142 epithelial ovarian cancer specimens. Immunohistochemistry was performed for the presence of CD68+ macrophages. The distribution of macrophages was evaluated separately in tumor and stromal tissue. Clinical characteristics were recorded and presence or absence of intratumoral macrophages was correlated with clinical characteristics including survival. Results Median follow-up for the entire cohort was 32.0 months (range, 1.7-170 months), and median progression-free survival (PFS) and overall survival (OS) were 14.1 months and 47.8 months, respectively. Intratumoral macrophages (ITMs) were present in 132/142 patients (91.5%) and absent in 12/142 (8.5%). Patients whose tumor tissue did not contain ITMs had a significantly longer median PFS (not reached, p = 0.009) and median OS (150.1 months, p=0.03), compared with the median PFS and OS of 11.7 and 47.7 months, respectively, among patients with ITMs. Interestingly, we could not demonstrate differences in PFS and OS when stromal macrophages were evaluated separately. The presence of ITMs was an independent prognostic factor for OS in a multivariate analysis (p=0.009). The Cox proportional hazard ratios for presence of ITMs were 3.55 for PFS (95% CI, 1.38-12.13) and 3.62 for OS (95% CI, 1.33-13.08). Conclusions Our study shows that the presence of intratumoral but not stromal macrophages correlates with poor prognosis in epithelial ovarian carcinoma. Citation Format: Wafic El Masri, Caroline Hillerup, Charlotte Topka, Chintda Santiskulvong, Alexander Chiang, Lily Wu, Jianyu Rao, Oliver Dorigo. Tumor associated macrophages are associated with poor survival in epithelial ovarian cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1543. doi:10.1158/1538-7445.AM2013-1543
Blanket hepatitis B vaccination is questionable in India
Authors: Peter R Mansfield, Anant Phadke, Ashok Kale
Journal: BMJ (2006)

A reply to 900 doctorsEditor-Why is anyone still giving space to proposals for insurance-based care? 1 The Treasury has rejected it under every government, so has the Wanless report, so does the BMA, simply because it is the most costly and least efficient way to deliver.If everyone is included at all levels of risk, and we all agree to help our fellow citizens when they need it, why waste from a quarter to a half of the cost on administration and (if private sector insurance is involved) profit for shareholders?This country was on its knees in 1948, but still we voted to be members one of another, and our brothers' and sisters' keepers.Who dares to say now that we can no longer afford this?That English NHS hospitals can now keep afloat only by opening private wards is no fault of the voters, who have never voted for such a return to barbarism.Nor will they in the future: which is why no major party has so far dared to give them the choice.
The Hong Kong College of Medicine (1887-1915).
Authors: J Kyle
Journal: BMJ (1979)

Visitors arriving for the joint clinical meeting of the British Medical Association in Hong Kong in November will land at Kai Tak International Airport. Kai perpetuates the memory of a talented local doctor who had a vital role in establishing the first British medical school in East Asia, and later in founding the University of Hong Kong. In 1843, two years after Hong Kong island became a British possession, a medical missionary hospital was opened to provide the benefits of Western medical knowledge to the small Chinese population. Most of the Chinese, however, preferred traditional herbal remedies. The European-trained doctors were moved to other cities in mainland China, and the first hospital venture closed down after a few years. Further efforts by other missionary organisations failed for similar reasons. A purely Chinese hospital, the Tung Wah, was established in 1875.
ARE MYELOPEROXIDASE LEVELS ASSOCIATED WITH ACUTE CORONARY SYNDROME? A META-ANALYSIS
Authors: Haris Riaz, Mehak Idrees, Muhammad Shahzeb Khan, Sajjad Gul, Talha Riaz, Abdul Nafey Kazi, Moaath Mustafa, Jamal Mahar, Meghan McCarthy, Ahmadreza Karimianpour
Journal: Journal of the American College of Cardiology (2015)
Transplantation of the heart and both lungs: II. Experimental cardiopulmonary transplantation
Authors: D. B. Longmore, D. K. C. Cooper, R. W. Hall, J. Sekabunga, W. Welch
Journal: Thorax (1969)

Anti-bacteriophage T4, anti-poly-d-alanyl and anti-penicilloyl antibodies were isolated from the sera of goats and rabbits at different times after immunization by means of water-insoluble immunoadsorbents prepared with bromoacetyl cellulose. The isolated antibody preparations were separated into IgM and IgG fractions. The relative efficiency of the isolated IgM and IgG antibodies in inactivating bacteriophage T4, poly-d-alanyl bacteriophage and penicilloyl bacteriophage differed with respect to the time after injection at which sera were collected, the method of plating and the specificity of the respective antibody used for the inactivation, leading to the conclusion that it is not possible to determine the respective concentration of antibodies of the two classes exclusively from phage inactivation measurements.
Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice
Authors: Dejing Pan, Tibor Schomber, Christian P. Kalberer, Luigi M. Terracciano, Katrin Hafen, Werner Krenger, Hui Hao-Shen, Chuxia Deng, Radek C. Skoda
Journal: Blood (2007)
Abstract 1759: Immunohistochemical detection of human telomerase reverse transcriptase in human cholangiocarcinoma and risk condition.
Authors: Kanenori Endo, Shunichi Tsujitani, Miwa Yoshimoto, Jyoji Watanabe, Naruo Tokuyasu, Teruhisa Sakamoto, Takuji Naka, Yasuaki Hirooka, Masahide Ikeguchi
Journal: Cancer Research (2013)

Abstract Background/Aims: Telomerase activation plays a critical role in several human carcinogenesis through the maintenance of telomeres. The catalytic subunit of telomerase is human telomerase reverse transcriptase (hTERT), whose expression is the critical determinant of telomerase activity. Studies on hTERT in human cholangiocarcinoma (ChC) are rare, and there are no immunohistochemical studies on the correlations with its expressions and ChC patient's clinicopathological parameters. Methods : HTERT Immunoreactivity was measured in cancerous parenchyma of 28 archival cases of human cholangiocarcinoma (ChC) compared with hyperplastic small biliary ducts in surrounding non-neoplastic liver. And hTERT immunoreactivity was also assessed in both large and small hyperplastic biliary ducts (HBDs) in 9 archival cases of primary sclerosing cholangitis (PSC), which is risk condition for human cholangiocarcinogenesis. Measurements of intrahepatic biliary duct sizes and quantitative microdensitometry measurements of immunostaining intensities were determined using a color video image analysis system. Micro-optical density values related to a standard optical density curve were generated for each set of measurements, using arbitrary units of immunostaining intensity ranging from 0 (nondetectable) to 255 (highest intensity). Results : HTERT immunoreactivity was presented in nuclei of ChC and PSC cells. Mean micro-optical density values for hTERT in tumorous cells were almost 8-fold greater than that measured in small HBDs in surrounding non-tumorous liver within the same tissue sections. Although there was no significantly difference of tumor differentiation in hTERT expression, its expression was stronger in tubular type than in papillary type and in tubulopapillary type. In PSC cases, hTERT expression was significantly stronger in large HBDs (&amp;gt;500μm cross-sectional diameter) than in small HBDs (&amp;lt;500μm cross-sectional diameter). Conclusion : Our findings suggest that hTRET protein in human ChC may emerge at a early stage in the progression of the malignant process. The results also suggest hTERT as potentially important targets relevant to chemoprevention or adjunct therapy of ChC. Citation Format: Kanenori Endo, Shunichi Tsujitani, Miwa Yoshimoto, Jyoji Watanabe, Naruo Tokuyasu, Teruhisa Sakamoto, Takuji Naka, Yasuaki Hirooka, Masahide Ikeguchi. Immunohistochemical detection of human telomerase reverse transcriptase in human cholangiocarcinoma and risk condition. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1759. doi:10.1158/1538-7445.AM2013-1759