tbuckley/cabot-search huggingface dataset:
ACUTE GRAVES' DISEASE.
Authors: JAMES R. ARNEILL
Journal: JAMA (1900)

The diseases described in text-books under the heading, "Diseases of the ductless glands," are usually chronic in their course. There are interesting exceptions to this rule. Fussell and Taylor have collected from literature 56 cases of acute leukemia in which death occurred in from two to three months. Graves' disease is still more strikingly chronic in its course. The number of fatal cases of acute Graves' disease reported by American authors is remarkably small. The only fatal cases which I have been able to find are those of J. H. Lloyd<sup>1</sup>and F. P. Henry.<sup>2</sup>A few cases have been reported in which the symptoms of Graves' disease came on suddenly, lasted for a few days, and disappeared with recovery. In French, and especially in German, literature, the reported cases are more numerous, but still rare. Cases of this interesting form of the disease have been reported by
Report of Biochemical and Dietary Procedures For Use in the Study of Metabolic Functions and For the Evaluation of Nutritional Status
Authors: Ogden C. Johnson
Journal: JAMA (1960)

This book is a preliminary revision of "Metabolic Methods" published in 1951 by C. V. Mosby Company, St. Louis, Mo., and written by the present authors and Miss Evelyn Marek. It attempts to bring up to date the procedures used in conducting metabolic and nutritional surveys. The information and background gained during the past 10 years of field survey work by the Army Medical Research and Nutrition Laboratory and during surveys conducted by Interdepartmental Committee on Nutrition for National Defense (ICNND) has been included in this manual. Since the manual is designed for actual designing and conducting surveys, it goes into great detail on equipment needed; preparation of solutions required for analytical tests; forms required for collecting, compiling, and summarizing data; and procedures used for all types of analyses. Analytical methods are described with great detail as to conducting the test, but little information on the principle behind the procedure
Reversible phagocytosis in rabbit polymorphonuclear leukocytes.
Authors: R D Berlin, J P Fera, J R Pfeiffer
Journal: Journal of Clinical Investigation (1979)

We have studied the fate of inert phagocytized particles in rabbit neutrophils. Neutrophils release significant quantities of preingested oil emulsion. Roughly 50% of an ingested load is released in 40 min at 37 degrees C. By electron microscopy the process of release appears to be by exocytosis: particles appear extruded through a network of processes often accompanied by membranous vesicles. Exocytosis is temperature and glucose dependent but unlike phagocytosis does not require divalent cations. From Coulter counter measurements virtually the entire cell population appears to undergo the phagocytosis-exocytosis sequence. Neutrophils undergoing exocytosis remain intact as determined by direct counts, electron microscopy, and absence of lactate dehydrogenase release. Moreover, by sequentially feeding differently labeled particles, it is shown that the processes of phagocytosis and exocytosis can occur concurrently. Indeed, it is found that ingestion accelerates release. The implications of these phenomena for membrane recycling, lysosomal enzyme release, and the killing of microorganisms are briefly discussed.
Evaluation and Management Services in the Resource-Based Relative Value Scale
Authors: Peter Braun
Journal: JAMA (1988)

Evaluation and management (E/M) services, which include making diagnoses, counseling and educating, developing strategies of care, and following up on treatment, are common to all medical specialties. Surveys of a variety of specialists using the magnitude-estimation method show that physicians agree closely in rating the work of particular E/M services. Regardless of the type of E/M service, the site at which it is performed, or the specialty performing it, work per unit of time varies only slightly. Comparison of work and time for services to which experts assigned billing codes in our consultative process indicates, however, that there may be large differences in the way different specialties use these billing codes. In some instances, work entailed by some of the E/M billing codes within specialties also appears to vary substantially. If empirical studies of physicians' coding and billing practices support our findings, possible responses might include (1) developing specialty-specific resource-based relative values for E/M services and (2) redefining thePhysicians' Current Procedural Terminology, edition 4, codes for these services in terms that include time specifications.  (JAMA1988;260:2409-2417)
THE RELATION OF THE INTERNAL SECRETIONS TO EPILEPSY. PUERPERAL ECLAMPSIA AND KINDRED DISORDERS.
Authors: CHARLES E. DE M. SAJOUS
Journal: JAMA (1905)

A suggestive coincidence bearing directly on the disorders referred to in this paper, epilepsy, puerperal septicemia, tetanus and hydrophobia, is that several investigators have been led to conclude by experiments, in which each organ was studied individually, that the adrenals, the pituitary body and thyroid not only influence metabolism, but that they are also concerned with the destruction of toxic waste-products. Thus, in 1891, Abelous and Langlois<sup>1</sup>advanced the view that the function of the adrenals was to "neutralize or destroy toxic substances produced or elaborated during chemical interchanges, and particularly those resulting from muscular work." In 1894 Lloyd Andriezen<sup>2</sup>concluded that "the pituitary gland exercises a trophic action on the nerve tissues, which, in more definite terms, means enabling them,<i>a</i>, to take up and assimilate oxygen from the blood stream, and,<i>b</i>, to destroy and render innocuous the waste-products of metabolism." As to the thyroid, it
Mortality among second generation Irish in England and Wales
Authors: J. Haskey
Journal: BMJ (1996)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Mortality among second generation Irish in England and Wales Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Rituximab in Patients with the Steroid-Resistant Nephrotic Syndrome
Authors: Arvind Bagga, Aditi Sinha, Asha Moudgil
Journal: New England Journal of Medicine (2007)

To the Editor: The treatment of patients with the steroid-resistant nephrotic syndrome (SRNS) is challenging. Persistent proteinuria and hypoalbuminemia result in serious complications and progressive kidney disease. Intensive treatment regimens show varying results in inducing remission but are associated with adverse effects. On the basis of suggestions that B lymphocytes are crucial in the pathogenesis of the nephrotic syndrome,1 we examined the efficacy of treatment with rituximab, a monoclonal antibody against CD20 antigen, in patients with SRNS that was resistant to treatment with high-dose corticosteroids, alkylating agents, and calcineurin inhibitors. Five patients (three with initial resistance and two with late . . .
Basic aspects related to penicillin‐allergy skin testing: on the variability of the hapten‐paratope interaction
Authors: J. Bondaruk, V. Curcio‐Vonlanthen, C. H. Schneider
Journal: Allergy (1995)

Ampicillin and benzylpenicillin conjugated to human serum albumin were used as immunogens in order to obtain antihaptenic IgG responses in outbred guinea pigs according to different schedules, all involving complete Freund's adjuvant. The individual responses were characterized by ELISA and by ELISA inhibition using ampicillin, benzylpenicillin, and carbenicillin peptidic conjugates for coating and for inhibition. In several instances, drastically reduced cross‐reactivity and even its absence were observed, although the penicillin antigens differ only in the side‐chain. The notion that the invariantly present thiazolidine ring will always provide significant binding to antibodies against all penicillins differing only in the side‐chain has to be dropped. The experiments were performed in relation to newer findings of clinical penicillin‐allergy skin testing which suggest that benzylpenicillin‐based reagents alone are not able to detect or predict all reactions against semisynthetic penicillins. The experimental evidence here obtained corroborates this conclusion.
Frequency of Early Occlusion and Stenosis in a Left Internal Mammary Artery to Left Anterior Descending Artery Bypass Graft After Surgery Through a Median Sternotomy on Conventional Bypass
Authors: Peter B. Berger, Edwin L. Alderman, Andrea Nadel, Hartzell V. Schaff
Journal: Circulation (1999)

Background —Uncertainty exists regarding the frequency of early occlusion when the left internal mammary artery (LIMA) is anastomosed to the left anterior descending artery (LAD) through a sternotomy with conventional coronary artery bypass grafting (CABG). The issue has gained importance for comparison with less invasive surgical approaches in which operative exposure may be limited and graft anastomosis more difficult. Methods and Results —Data were analyzed from the International Multicenter Aprotinin Graft Patency Experience (IMAGE) trial in which 617 patients underwent conventional CABG of the LAD with a LIMA between April 1993 and May 1995. Coronary angiography was performed a mean of 10.8 days postoperatively. Patients were randomized to receive intraoperative aprotinin, an inhibitor of several serine proteinases, or placebo. Because no differences existed in patency rates of LIMA grafts between patients who received aprotinin and placebo, both groups were analyzed collectively. On coronary angiography, the LIMA was widely patent (&lt;50% stenosis) in 561 patients (91%), had ≥50% and &lt;99% stenosis in 48 patients (7.8%), and was occluded in 8 patients (1.3%). Therefore, the LIMA was patent in 609 patients (98.7%). Conclusions —In the IMAGE trial, the largest and most contemporary early angiographic analysis of CABG available, early patency of the LIMA was &gt;98% when anastomosed to the LAD. These data provide an important benchmark for less invasive surgical approaches in which the LIMA is anastomosed to the LAD.
Duodenal Metastasis From Hepatocelluar Carcinoma Demonstrated on FDG PET/CT Imaging
Authors: Guang-Uei Hung, Yung-Hsiang Yeh, Yao-Li Chen, Jong-Kang Lee
Journal: Clinical Nuclear Medicine (2008)

It is rare for patients with hepatocellular carcinoma (HCC) to have gastrointestinal metastasis. We report on a 67-year-old man with HCC who was first treated with liver transplantation and then received transcatheter arterial embolization for recurrence in the right hepatic lobe. He underwent whole-body FDG PET/CT imaging for survey, and a FDG-avid lesion was localized in the duodenum. Endoscopic examination revealed an ulcerative tumor in the first portion of the duodenum. Histologic examination determined metastatic HCC.
Little grains of sand.
Authors: R Gibson
Journal: BMJ (1981)

In the Canary Island of Lanzarote there is a particularly excellent hotel from which an elderly man sets out each morning, irrespective of the weather, with a plastic bucket, a long-handled soft broom, and a dustpan, to sweep the terraces. He starts from the same corner and goes from one end of the top terrace down the twisting paths to the far end of the lowest level. He carefully sweeps round the recumbent bodies of browning Britons, Germans, or Scandinavians, clad in little more than a thick layer of sun lotion, and every now and then stoops to sweep a tiny pile of sand into his dustpan and from there into his bucket. I have never seen him at the end of his journey on the bottom terrace next to the sea, but I have no doubt that each day he ends up in the same corner. The wind and the rain, with leaves and twigs from trees and bric-?-brac from the beach, add to his work somewhat but may bring a welcome variation from the monotonous and almost invisible sand. I have no idea what sort of man he is. He has a peaceful look to him, a gentle smile, and seemingly endless patience. Moreover, he has chosen to go on working after he could have retired, boosting his income but preserving his independence and, with it, his self-respect and security. I found him well worth watching. It was justifiable to wonder why he bothered or to believe that his employers gave him this unskilled and repetitive job as a kindly gesture to keep him occupied. Yet, roads, steps, and pavements outside the hotel, apparently not so carefully tended, are piled high with dust, sand, and unconcealed tourist pollution. Which must give us pause, I think, for there is clearly more to this than meets the superficial glance. I would like to sketch a brief history of the care of the elderly over the past century and a half, from the years when humani tarianism, seriousness of thought, self-discipline, and self reliance were becoming uppermost in peoples' thoughts.
Zeiterlebnis und Ich-Störung
Authors: Georges Tamarin
Journal: Psychotherapy and Psychosomatics (1960)

Research Articles| February 10 2010 Zeiterlebnis und Ich-Störung Subject Area: Psychiatry and Psychology Georges Tamarin Georges Tamarin Tel-Aviv Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1960) 8 (1): 53–67. https://doi.org/10.1159/000285705 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Georges Tamarin; Zeiterlebnis und Ich-Störung. Acta Psychotherapeutica et Psychosomatica 1 January 1960; 8 (1): 53–67. https://doi.org/10.1159/000285705 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1960Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Unilateral Adrenal Hemorrhage during ACTH Therapy
Authors: Miles A. Galin
Journal: New England Journal of Medicine (1958)

OF the complications encountered in the use of ACTH and corticosteroid therapy, abdominal catastrophes rank high. The problem of peptic ulcer and visceral perforation is well known. However, the occurrence of adrenal hemorrhage after ACTH therapy is exceedingly rare. Two cases of bilateral hemorrhage have been reported, 1 occurring in a patient with ulcerative colitis1 and the other in a patient with moderately severe hypertension.2 In the following case unilateral adrenal hemorrhage occurred during ACTH therapy for retrobulbar neuritis.Case ReportMrs. H.B., a 39-year-old woman, entered the New York Hospital in January, 1957, because of retrobulbar neuritis on the . . .
555 Improved detection of active hepatitis C virus infection in cadaver donors using transcription mediated amplification assay
Authors: C CHINCHILLA, L CORADO, S ASWAD, T MOONE, R MENDEZ, R MENDEZ, N KHAN
Journal: Hepatology (2003)

In order to prevent the spread of the hepatitis C virus (HCV) amongst people who inject drugs (PWID), it is imperative that any injecting risk behaviour which may contribute to the transmission of disease has its role quantified. To inform public health organisations, mathematical modelling techniques were used to explore the risk of HCV infection through the sharing of injecting paraphernalia (including filters, cookers and water).A mathematical model was developed for the spread of HCV based on the injecting behaviour of PWID in Scotland, with transmission occurring through the sharing of needles/syringes and other injecting paraphernalia. Numerical simulations were used to estimate the transmission probability for HCV through the sharing of injecting paraphernalia such that the modelled endemic HCV prevalence fitted with that observed amongst PWID in Scotland.The transmission probability of HCV through injecting paraphernalia was modelled to be over 8 times lower than that through needles/syringes (approximately 0.19–0.30% and 2.5%, respectively), assuming transmission occurs through a combination of at least filters and cookers. In the context of reported needle/syringe and paraphernalia sharing rates in Scotland, it is estimated that 38% and 62% of HCV infections are contributed by these practices, respectively. If needle/syringe sharing rates were to be twice those reported, the contributions would be 70% and 30%, respectively.Given that the sharing of injecting paraphernalia among PWID is common, HCV transmission through this route could be contributing to the growing healthcare burden associated with this chronic disease. Every effort should therefore be made to establish (a) the contribution that paraphernalia sharing is making to the spread of HCV, and (b) the effectiveness of services providing sterile paraphernalia in preventing infection.
Determinants of drug response in severe chronic heart failure. 1. Activation of vasoconstrictor forces during vasodilator therapy.
Authors: M Packer, J Meller, N Medina, M Yushak, R Gorlin
Journal: Circulation (1981)

Vasodilator drugs activate neurohumoral forces that produce peripheral vasoconstriction and tachycardia and probably cause the rebound events observed upon abrupt withdrawal of therapy. To determine their role in limiting therapeutic vasodilator responses, these reactive forces were measured in 40 patients with severe chronic heart failure by quantifying the magnitude of rebound change (MRC) after nitroprusside withdrawal. Group 1 patients (n = 22), who had minimal reactive vasoconstriction (MRC less than or equal to 27%), showed marked hemodynamic effects with nitroprusside (4.5 microgram/kg/min) and isosorbide dinitrate (40 mg orally), associated with significant decreases in heart rate with both drugs (p less than 0.001). Despite administration of the same doses of both drugs, group 2 patients (n = 18), who had marked rebound changes (MRC greater than 27%), showed significantly smaller changes in cardiac index, systemic vascular resistance and mean arterial pressure (p less than 0.001), associated with no change or increases in heart rate. Rebound events were attenuated and the responses to nitroprusside and nitrates were enhanced in four patients in whom these drugs were readministered after pretreatment with i.v. phentolamine (0.3mg/min). We conclude that activation of neurohumoral forces can limit the hemodynamic responses to vasodilator administration; this supports the use of combination therapy of direct-acting vasodilators and neurohumoral antagonists in selected patients with severe chronic heart failure.
Renal Cell Carcinoma
Authors: Brendan D. Curti
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ROYAL SOCIETY OF MEDICINE..
Authors: G. B. Dowling
Journal: British Journal of Dermatology (1953)

Journal Article ROYAL SOCIETY OF MEDICINE.: SECTION OF DERMATOLOGY Get access G. B. Dowling G. B. Dowling Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 65, Issue 7-8, 1 July 1953, Pages 280–285, https://doi.org/10.1111/j.1365-2133.1953.tb13750.x Published: 01 July 1953
Transferrin synthesis by inducer T lymphocytes.
Authors: J B Lum, A J Infante, D M Makker, F Yang, B H Bowman
Journal: Journal of Clinical Investigation (1986)

Transferrin (Tf) is a growth factor that transports iron in plasma. It is essential for proliferation of activated T lymphocytes. Previous studies have suggested that peripheral blood cells are capable of synthesizing Tf. Using in situ hybridization techniques and human Tf complementary DNAs as probes, peripheral blood cells have been examined for sites of Tf messenger RNA (mRNA) transcription. The studies described here demonstrate that Tf is synthesized by a specific subset of T lymphocytes, the T4+ inducer subset. T lymphocyte proliferation is dependent upon the presence of both interleukin 2 (IL-2) and Tf, even though resting cells do not possess receptors for either. The present studies indicate that during T cell activation, induction of IL-2 mRNA transcription and IL-2 receptor expression precede the transcription of Tf mRNA and expression of Tf receptors, respectively. These events in turn precede the initiation of DNA synthesis. Transferrin and its receptor appear to be involved in an autocrine pathway which is functionally linked to the IL-2/IL-2 receptor autocrine loop.
Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels
Authors: Anna Wonnerth, Katharina M. Katsaros, Konstantin A. Krychtiuk, Walter S. Speidl, Christoph Kaun, Kylie Thaler, Kurt Huber, Johann Wojta, Gerald Maurer, Ingebjorg Seljeflot, Harald Arnesen, Thomas W. Weiss
Journal: Metabolism (2014)