tbuckley/cabot-search huggingface dataset:
HYPERCALCEMIA OF CANCER
Authors: GEORGE C. SCHUSSLER
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 June 1969HYPERCALCEMIA OF CANCERGEORGE C. SCHUSSLER, M.D., F.A.C.P.GEORGE C. SCHUSSLER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-6-1280_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In the editorial note on the measurement of parathyroid hormone (PTH) (1) Dr. Reiss points out that immunoassayable parathyroid hormone has been found in the serum of hypercalcemic patients with nonparathyroid tumors. In the study by Berson and Yalow (2), which is referred to, the immunoassays were actually done on sera fromnormocalcemicpatients with bronchogenic carcinoma. Many of these patients had higher than normal plasma concentrations of immunoassayable PTH. The lack of hypercalcemia in these patients could be interpreted as a negative endogenous bioassay and may reflect on the adequacy of the immunoassay as a measure...References1. REISS E: Measurement of parathyroid hormone. Ann. Intern. Med. 69: 1325, 1968. LinkGoogle Scholar2. BERSONYALOW SARS: Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia and bronchogenic carcinoma. Science 154: 907, 1966. CrossrefMedlineGoogle Scholar3. SHERWOODO'RIORDANAURBACHPOTTS LMJLGDJT: Production of parathyroid hormone by nonparathyroid tumors. J. Clin. Endocr. 27: 140, 1967. CrossrefMedlineGoogle Scholar4. LAFFERTY WF: Pseudohyperparathyroidism. Medicine (Balt.) 45: 247, 1966. CrossrefMedlineGoogle Scholar5. SCHUSSLERKANSKI GCJR: Hypophosphatemia in the hypercalcemia of malignancy. Unpublished observations. Google Scholar6. REISSCANTERBURY EJM: A radioimmunoassay for parathyroid hormone in man. Proc. Soc. Exp. Biol. Med. 128: 501, 1968. CrossrefMedlineGoogle Scholar7. STROTTNUGENT CACA: Laboratory tests in the diagnosis of hyperparathyroidism in hypercalcemic patients. Ann. Intern. Med. 68: 188, 1968. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE C. SCHUSSLER, M.D., F.A.C.P. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1969Volume 70, Issue 6Page: 1280-1281KeywordsAttentionBioassays and physiological analysisBlood plasmaCancer immunotherapyHypercalcemiaImmunoassaysParathyroid hormone ePublished: 1 December 2008 Issue Published: 1 June 1969 PDF downloadLoading ...
Herniated Lumbar Disks
Authors: John L. Zeller, Alison E. Burke, Richard M. Glass
Journal: JAMA (2006)

Natural aging process-ongoing loss of water and proteins from the disk • Genetic (inherited) predisposition-an accelerated degeneration of disk materials • Obesity-excessive body weight places added stress on the spine • Lack of exercise-results in a loss of trunk muscle strength and diminished spine support • Work activities-long periods of sitting, lifting or pulling heavy objects, frequent bending or twisting, heavy physical exertion, repetitive motions, or exposure to constant vibration • Smoking-deprives blood flow and nutrients needed for disk repairs • History of back injury, previous herniated disk, or prior back surgery
Making bone marrow transplants more safe
Authors: A. Skolnick
Journal: JAMA (1991)

PATIENTS who undergo bone marrow transplants usually undergo total-body irradiation of up to 14 Gy.  Unfortunately, this radiation spares no part of the body, panelist Peter Tutschka, MD, professor of medicine and pathology and director of the Bone Marrow Transportation Division, Ohio State University, Columbus, told the American Cancer Society seminar in Phoeniz.  Severe and often intractable nausea and vomiting followed by diarrhea attests to the toxicity on the gastrointestinal tract, he says.  Among other adverse effects are damage to the lungs, liver, kidney, central nervous system, and endocrine glands that leads to sterility in adults and impaired sexual development and stunted growth in children. Radiation also impairs the microenvironment for the marrow graft to develop, which leads to delayed recovery of marrow function and a resulting high rate of infections and bleeding problems.  Despite these tremendous side effects, total-body irradiation is not a very effective antileukemic agent, he says,
The Developmental Origins of Voice Processing in the Human Brain
Authors: Tobias Grossmann, Regine Oberecker, Stefan Paul Koch, Angela D. Friederici
Journal: Neuron (2010)

In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior temporal cortex to the human voice when compared to nonvocal sounds, suggesting that voice-sensitive brain systems emerge between 4 and 7 months of age. In experiment 2, 7-month-old infants listened to words spoken with neutral, happy, or angry prosody. Hearing emotional prosody resulted in increased responses in a voice-sensitive region in the right hemisphere. Moreover, a region in right inferior frontal cortex taken to serve evaluative functions in the adult brain showed particular sensitivity to happy prosody. The pattern of findings suggests that temporal regions specialize in processing voices very early in development and that, already in infancy, emotions differentially modulate voice processing in the right hemisphere.
Familial Carriers and Meningococcal Meningitis
Authors: Sheldon Greenfield, Harry A. Feldman
Journal: New England Journal of Medicine (1967)

INTEREST in meningococcal disease was reawakened by the demonstration in 1963 of sulfonamide resistance in a significant number of strains of the causative organisms.1 Military surveys, in both epidemic and nonepidemic periods,2 3 4 5 6 have been abundant, but there have been few attempts to study the meningococcus in civilian populations. When performed, such investigations have generally focused on the immediate families of patients. They have not defined the relation of isolated cases both to the microcommunity in which they occurred and to the larger urban population.7 8 9 10 11 12 13 The admission to the hospital of 3 young first cousins with meningococcal meningitis during a six-month . . .
TEMPORAL CHANGES OF NEOINTIMAL COVERAGE AND THROMBOGENICITY AFTER DRUG-ELUTING STENT IMPLANTATION; ANGIOSCOPIC COMPARISON BETWEEN SIROLIMUS-ELUTING AND PACLITAXEL-ELUTING STENT
Authors: Masahiko Hara, Masami Nishino, Takeshi Masaki, Naoki Mori, Takahiro Yoshimura, Yasuharu Lee, Daisuke Nakamura, Shinpei Nakatani, Masayuki Taniike, Nobuhiko Makino, Hiroyasu Kato, Yasuyuki Egami, Ryu Shutta, Hitoshi Yamaguchi, Jun Tanouchi, Yoshio Yamada
Journal: Journal of the American College of Cardiology (2010)
Health campaigners attack government plans to remove calories from foods as "token gestures"
Authors: M. Limb
Journal: BMJ (2012)

The government has come under fire for a crackdown on obesity based on food and drink companies’ “pledges” to restrict the calorie content of some products.

Critics have warned that the scheme in England benefits businesses more than people’s health and falls a long way short of measures needed to reduce rates of obesity that are among the highest in the developed world.

Seventeen companies have signed up to the government’s Responsibility Deal to reduce calorie consumption.They are: Asda, Beefeater (Whitbread), Coca-Cola Great Britain, Compass, Kerry Foods, Kraft, Marks & Spencer, Mars, Morrisons, Nestle, PepsiCo, Premier Foods, Sainsbury’s, Subway, Tesco, Unilever, and Waitrose.

Coca-Cola Great Britain says it will reduce the calories in some of …
A National Cholera Vaccine Stockpile — A New Humanitarian and Diplomatic Resource
Authors: Matthew K. Waldor, Peter J. Hotez, John D. Clemens
Journal: New England Journal of Medicine (2010)

Cholera is a severe and often rapidly fatal diarrheal disease caused by the bacterium Vibrio cholerae. People die from cholera because the pathogen elicits the secretion of large quantities (up to 20 liters daily) of bacteria-laden fluid from the intestine, resulting in extreme dehydration. If supplies of drinking water or food become contaminated with V. cholerae, the disease can spread through a population very rapidly. Cholera has afflicted humans for thousands of years and has led to millions of deaths. It is endemic in many parts of South Asia, and it can cause epidemics both in areas where it . . .
SIMPLE METHODS FOR PROLONGING THE VIABILITY OF MENINGOCOCCUS CULTURES
Authors: DOLORES E. BRADLEY
Journal: JAMA (1918)

The old problem of maintaining stock cultures of meningococci presented itself in our laboratory during the past year. An unusual demand for reliable control cultures has developed in connection with the detection of meningitic carriers in Army cantonments and naval training stations. The maintenance of a large number of cultures for preparing highly polyvalent antimeningitis serum has been a perennial problem of the manufacturer. The transportation of meningitis cultures presents especial difficulties. Cultures brought to this coast from New York on several occasions were sent by special messenger and, while they were on the way, fresh subplants were made at Denver, yet only a small proportion arrived safely. Another case of interest was observed in Dr. Wollstein's 1 work on parameningococci. A hurried journey was made to Paris by Dr. Louise Pearce to secure two cultures from Dr. Dopter, since it was found that the cultures sent by post did
Toxicity of Penicillamine
Authors: John A. Goldman
Journal: JAMA (1979)

To the Editor.—  The article by Halverson and associates (240:1870, 1978) regarding the toxicity of penicillamine omits one important factor of toxicity, that is, the dose the patient was receiving.  This is one of the reasons that newer protocols for the administration of penicillamine stress the lower and slower dose schedules. It may well be that if the toxicity is dose related, and most rheumatologists are not using the highest doses that this group did, then the side effects stressed in this article are not pertinent to the present-day practice of using penicillamine for rheumatoid arthritis.
1-a-Hydroxyvitamin D3 in Chronic Renal Failure
Authors: James C. M. Chan
Journal: JAMA (1975)

In chronic renal disease, the synthesis of the kidney hormone, 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), is impaired, thus contributing to the development of renal osteodystrophy. The clinical use of 1,25-(OH)2D3 is limited, due to the complexity and expense of its chemical synthesis. This study reports the use of 1-alpha-hydroxyvitamin D3 (1-alpha-OH-D3), an active analogue of 1,25-(OH)2D3, in eight patients with chronic renal failure, five of whom were undergoing long-term hemodialysis. The drug was given orally for 6 to 260 days at a dosage of 1mug to 4mug/day. Short-term (21 days) balance studies showed an increase in intestinal calcium absorption and a simultaneous fall in serum parathyroid hormone levels during administration of 1-alpha-OH-D3. In two long-term studies (160 and 260 days), roentgenographic improvement of renal osteodystrophy was seen after 45 and 185 days, respectively. The data indicate that 1-alpha-OH-D3 holds considerable promise for the prevention and treatment of renal osteodystrophy.
Character Defenses and Biofeedback
Authors: Stephen H. Armstrong, Mitchell Hendrix
Journal: Psychotherapy and Psychosomatics (1976)

One aspect of biofeedback treatment with chronically incapacitated persons concerns their resistance to getting better. In effect, the removal of their symptom is equivalent to undercutting a characteristic way of relating to themselves and to the world, and hence, is opposed. Even though many biofeedback procedures are impressively effective, the therapist must watch for another symptom reemerging in the place of the older somatic complaint, or for psychologically regressive attempts to preserve one's character defenses.
Optimal weekly frequency of 308-nm excimer laser treatment in vitiligo patients
Authors: A. Hofer, A.S. Hassan, F.J. Legat, H. Kerl, P. Wolf
Journal: British Journal of Dermatology (2005)

Recently the beneficial effect of excimer laser treatment has been reported for patients with vitiligo. The influence of treatment frequency on this effect is not clear.To determine the optimal frequency of 308-nm excimer laser therapy for vitiligo.In this prospective, university-based hospital study over 12 weeks we enrolled 14 patients. Each had at least three stable vitiligo lesions in the same body area. The three stable vitiligo lesions in each subject were randomly assigned to receive excimer laser treatment once (1 x), twice (2 x) and three times (3 x) weekly, respectively. The initial ultraviolet (UV) dose was 50 mJ cm(-2) less than the 308-nm minimal erythematous dose in vitiligo skin. The UV dose was increased at each treatment session according to the erythematous response to the previous treatment.Thirteen subjects were treated for at least 6 weeks; seven were treated for all 12 weeks. At 6 weeks, the repigmentation rates for treated lesions were 8% (1/13) after 1 x weekly treatment, 23% (3/13) after 2 x weekly treatment and 62% (8/13) after 3 x weekly treatment (P = 0.0134; 3 x vs. 1 x weekly); at 12 weeks, these rates were 46% (6/13), 62% (8/13) and 69% (9/13), respectively (P = NS; 3 x vs. 1 x weekly). Repigmentation initiation correlated with treatment number, regardless of frequency (P = NS). As shown by Kaplan-Meier analysis, repigmentation occurred earliest in the most frequently treated lesions (P = 0.0336). At 12 weeks, the projected repigmentation rates for 1 x, 2 x and 3 x weekly treatment approached each other (60%, 79% and 82%, respectively); the mean repigmentation grades (on a scale of 0-5) for 1 x, 2 x and 3 x weekly treatment were 1.7, 2.4 and 3.3, respectively (P = 0.018; 3 x vs. 1 x weekly). Laser-induced repigmentation persisted in most cases over the entire follow-up of 12 months after the end of treatment.308-nm excimer laser therapy is effective against vitiligo. Although repigmentation occurs fastest with 3 x weekly treatment, the ultimate repigmentation initiation seems to depend entirely on the total number of treatments, not their frequency. However, treatment periods of more than 12 weeks may be necessary to obtain a satisfactory clinical repigmentation, particularly when vitiligo lesions are treated only 1 x or 2 x compared with 3 x weekly.
PET OR SPECT MYOCARDIAL PERFUSION IMAGING (MPI) IN SYMPTOMATIC DIABETIC PATIENTS? A DIAGNOSTIC EVALUATION
Authors: Srilatha R. Ayirala, Nishant Sethi, Shishir Mathur, ChetanKumar Chauhan, Deborah Katten, Alan Ahlberg, Gary V. Heller
Journal: Journal of the American College of Cardiology (2011)
Abstract CT223: Dendritic cells pulsed with Wilms′ tumor gene 1 (WT1)-specific and MHC class I and II-restricted epitopes with gemcitabine induce antitumor immune responses in patients with advanced pancreatic cancer
Authors: Shigeo Koido, Sadamu Homma, Masato Okamoto, Masako Mori, Shinji Yoshizaki, Kazuki Takakura, Kazumi Hayashi, Shin Kan, Takafumi Ishidao, Sei-ichi Yusa, Shigetaka Shimodaira, Kan Uchiyama, Mikio Kajihara, Hiroo Imazu, Hiroshi Arakawa, Toshifumi Ohkusa, Hisao Tajiri
Journal: Cancer Research (2014)

Abstract Wilms' tumor gene 1 (WT1) protein is an attractive target for cancer immunotherapy. To evaluate whether dendritic cells (DCs) pulsed with WT1-specific and MHC class I and II-restricted epitopes in combination with gemcitabine induce antitumor immune responses and improve clinical outcome in patients with advanced pancreatic cancer, we investigated the clinical and immunologic responses to the chemoimmunotherapy. Ten pancreatic cancer patients with stage IV and HLA positive for HLA-A*02:01, A*02:06, A*24:02, DRB1*04:05, DRB1*08:03, DRB1*15:02, DRB1*15:01, DPB1*09:01, or DPB1*05:01 were enrolled in this study. Patients first received gemcitabine on days 1, 8, and 15, followed by intradermal vaccinations with DCs pulsed with MHC class I or II alone (n=3), or MHC-I/II-restricted WT1 peptides (n=7) depending on their HLA biweekly and gemcitabine on days 1, 8, and 15 of a 28-day cycle. In 4 of 7 patients vaccinated with MHC-I/II pulsed DCs and none of 3 patients vaccinated with MHC-I or -II pulsed DCs, we detected WT1 peptide-specific delayed-type hypersensitivity (DTH). Among ten enrolled patients, DTH-positive patients showed significantly improved clinical outcome, compared with negative patients. Moreover, longer survivors featured a higher frequency of memory-phenotype in WT1-specific cytotoxic T-lymphocytes after vaccination with MHC-I/II pulsed DCs. In conclusion, the combination therapy was well-tolerated and activation of WT1-specific immune responses may be associated with improved clinical responses for patients with advanced pancreatic cancer. Citation Format: Shigeo Koido, Sadamu Homma, Masato Okamoto, Masako Mori, Shinji Yoshizaki, Kazuki Takakura, Kazumi Hayashi, Shin Kan, Takafumi Ishidao, Sei-ichi Yusa, Shigetaka Shimodaira, Kan Uchiyama, Mikio Kajihara, Hiroo Imazu, Hiroshi Arakawa, Toshifumi Ohkusa, Hisao Tajiri. Dendritic cells pulsed with Wilms′ tumor gene 1 (WT1)-specific and MHC class I and II-restricted epitopes with gemcitabine induce antitumor immune responses in patients with advanced pancreatic cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr CT223. doi:10.1158/1538-7445.AM2014-CT223
Plasma exchange in corticosteroid-resistant pemphigus
Authors: J.C. Roujeau, B. Kalis, P. Lauret, M.L. Flechet, M.Joneau Fabre, C. Andre, J. Revuz, R. Touraine
Journal: British Journal of Dermatology (1982)

Journal Article Plasma exchange in corticosteroid‐resistant pemphigus Get access J.C. Roujeau, J.C. Roujeau Department of Dermatology, Hôpital Henri Mondor, F 94 010 Creteil Search for other works by this author on: Oxford Academic Google Scholar B. Kalis, B. Kalis Department of Dermatology, Hôpital Sebastopol, F51 100 Reims, France Search for other works by this author on: Oxford Academic Google Scholar P. Lauret, P. Lauret Department of Dermatology, Hôpital Charles Nicolle, F 76 038 Rouen Search for other works by this author on: Oxford Academic Google Scholar M.L. Flechet, M.L. Flechet Department of Dermatology, Hôpital Charles Nicolle, F 76 038 Rouen Search for other works by this author on: Oxford Academic Google Scholar M.Joneau Fabre, M.Joneau Fabre Creteil Blood Centre, Hôpital Henri Mondor, F 94 010 Creteil Search for other works by this author on: Oxford Academic Google Scholar C. Andre, C. Andre Departmen of Immuno‐Haematology, Hôpital Henri Mondor, F 94 010 Creteil Search for other works by this author on: Oxford Academic Google Scholar J. Revuz, J. Revuz Department of Dermatology, Hôpital Henri Mondor, F 94 010 Creteil Search for other works by this author on: Oxford Academic Google Scholar R. Touraine R. Touraine Department of Dermatology, Hôpital Charles Nicolle, F 76 038 Rouen Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 106, Issue 1, 1 January 1982, Pages 103–104, https://doi.org/10.1111/j.1365-2133.1982.tb00909.x Published: 01 January 1982
A new beating heart preparation: Ultrastructural studies with special reference to vesiculation of intercalated discs
Authors: P. E. Roy, L. Gailis, P. J. Morin, G. Cote
Journal: Cardiovascular Research (1971)

An improved isolated blood perfused heart preparation was recently designed in this laboratory. The present work reports electron microscopic findings from dog myocardium kept beating in this system for 2 hr. To preserve structural integrity and to avoid artefacts, a new fixation technique was also developed. The studies show no significant differences between control and perfused myocardium. Both experimental groups present an excellent morphological preservation and, as revealed by myofibrils and bands alignment, a good symmetry of the contractile elements. The only noticeable modification is the presence of numerous vesicles in the intercalated disc. They are much more prominent in perfused than in control hearts. These vesicles are located in the undifferentiated region of the intercalated disc and contained various osmiophilic structures. The presence of similar vesicles in other areas of the cell, especially in lipofuscin granules or near disrupted granules, would suggest that the intercalated disc could be the excretory pathway of the myocardial cell. The present heart–lung preparation is therefore a valuable experimental tool for in vitro cardiac studies.
Subclinical Interstitial Lung Disease
Authors: Tracy J. Doyle, Gary M. Hunninghake, Ivan O. Rosas
Journal: American Journal of Respiratory and Critical Care Medicine (2012)

The widespread use of high-resolution computed tomography in clinical and research settings has increased the detection of interstitial lung abnormalities (ILA) in asymptomatic and undiagnosed individuals. We reported that in smokers, ILA were present in about 1 of every 12 high-resolution computed tomographic scans; however, the long-term significance of these subclinical changes remains unclear. Studies in families affected with pulmonary fibrosis, smokers with chronic obstructive pulmonary disease, and patients with inflammatory lung disease have shown that asymptomatic and undiagnosed individuals with ILA have reductions in lung volume, functional limitations, increased pulmonary symptoms, histopathologic changes, and molecular profiles similar to those observed in patients with clinically significant interstitial lung disease (ILD). These findings suggest that, in select at-risk populations, ILA may represent early stages of pulmonary fibrosis or subclinical ILD. The growing interest surrounding this topic is motivated by our poor understanding of the inciting events and natural history of ILD, coupled with a lack of effective therapies. In this perspective, we outline past and current research focused on validating radiologic, physiological, and molecular methods to detect subclinical ILD. We discuss the limitations of the available cross-sectional studies and the need for future longitudinal studies to determine the prognostic and therapeutic implications of subclinical ILD in populations at risk of developing clinically significant ILD.
Motor responses of the human alimentary tract to near-maximal infusions of pentagastrin.
Authors: J J Misiewicz, D J Holdstock, S L Waller
Journal: Gut (1967)

EDITORIAL COMMENT Near maximal infusions of pentagastrin were found to have no consistent effect upon motility except in the gastric antrum.The results suggest that gastrin is not directly concerned in the mediation of the gastro-colic reflex.
Relationship between adult victims of assault and children at risk of abuse.
Authors: L Ward, J P Shepherd, A M Emond
Journal: BMJ (1993)

frequency necessary to obtain sustained improvement.Until further information is available we recommend that portable hyperbaric chambers must be used only to facilitate but not to delay descent when illness occurs at high altitude.We thank the Sezione Varallo of the Italian Alpine Club for providing the locations in the Capanna Margherita, and the Swiss Army for transporting some of the equipment.