Rheumatoid Lung Disease
Authors: C. DOWELL PATTERSON
Journal: Annals of Internal Medicine (1965)

Article1 April 1965Rheumatoid Lung DiseaseC. DOWELL PATTERSON, M.D., WILLIAM E. HARVILLE, M.D., JOHN A. PIERCE, M.D., F.A.C.P.C. DOWELL PATTERSON, M.D.Search for more papers by this author, WILLIAM E. HARVILLE, M.D.Search for more papers by this author, JOHN A. PIERCE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-685 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRheumatoid arthritis is a systemic disease characterized by pain and disability in peripheral joints. The disease may affect any organ but exhibits a strong preference for tissues abundant in mucopolysaccharide as, for example, the joints, other serous surfaces, the eye, and the arteries. Although etiology remains obscure, immune responses may be important. The most typical histologic lesion is the necrobiotic granuloma. This is an inflammatory mass with a central zone of necrosis surrounded by a fibrous layer of palisaded connective-tissue cells in a matrix containing scattered chronic inflammatory cells such as lymphocytes, plasma cells, and histiocytes. This histologic lesion is...References1. ELLMANBALL PRE: 'Rheumatoid disease' with joint and pulmonary manifestations. Brit. Med. J. 2: 816, 1948. CrossrefMedlineGoogle Scholar2. BYWATERSCARTERSCOTT EGMEFE: Comparison of differential agglutination titre (D. A. T.) in juvenile and adult rheumatoid arthritis. Ann. Rheum. Dis. 18: 233, 1959. CrossrefMedlineGoogle Scholar3. CHRISTIE GS: Pulmonary lesions in rheumatoid arthritis. Aust. Ann. Med. 3: 49, 1954. CrossrefMedlineGoogle Scholar4. HARTMACKENZIE FDDH: Pulmonary rheumatoid disease. Brit. Med. J. 2: 890, 1955. CrossrefMedlineGoogle Scholar5. RUBIN EH: Pulmonary lesions in 'rheumatoid disease' with remarks on diffuse interstitial pulmonary fibrosis. Amer. J. Med. 19: 569, 1955. 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ARONOFFBYWATERSFEARNLEY AEGGR: Lung lesions in rheumatoid arthritis. Brit. Med. J. 2: 228, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Little Rock, ArkansasFrom the Departments of Medicine and Pathology, University of Arkansas Medical Center, Little Rock, Ark.This study was supported in part by grant HTS5333 from the National Heart Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to John A. Pierce, M.D., Department of Medicine, University of Arkansas Medical Center, 4301 West Markham, Little Rock, Ark. 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