"Pituitary Reserve" in Myxedema and Thyrotoxicosis
Authors: JEROME KOWAL
Journal: Annals of Internal Medicine (1963)

Article1 July 1963"Pituitary Reserve" in Myxedema and ThyrotoxicosisJEROME KOWAL, M.D., LOUIS J. SOFFER, M.D., F.A.C.P.JEROME KOWAL, M.D.Search for more papers by this author, LOUIS J. SOFFER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-79 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe effects of abnormal thyroid function on the elaboration and metabolism of carbon-19 and carbon-21 steroids have been well described (1-3). In hyperthyroidism, the metabolic degradation of these compounds is increased, the adrenal cortex compensating for this by an increased elaboration of these compounds. That this increased turnover may result in a limited pituitary or adrenal reserve in these patients is suggested by the efficacy of corticosteroids in the treatment of thyroid "storm" (4). However, Sagan, Perloff, and DiRaimondo (5) found a normal adrenal response to a single 8-hour intravenous infusion of adrenocorticotropic hormone (ACTH). Other investigators have confirmed this...References1. PETERSON RE: The miscible pool and turnover rate of adrenocortical steroids in man. Rec. Prog. Hormone Res. 15: 231, 1959. Google Scholar2. BROWNENGLERTWALLACH HES: Metabolism of free and conjugated 17-hydroxycorticosteroids in subjects with thyroid disease. J. Clin. Endocr. 18: 167, 1958. CrossrefMedlineGoogle Scholar3. LEVINDAUGHADAY EWH: The influence of the thyroid in adrenocortical function. J. Clin. Endocr. 15: 1499, 1955. CrossrefGoogle Scholar4. GOLDKENTFORSHAM EMJRPH: Clinical use of a new diagnostic agent, methopyrapone (SU-4885), in pituitary and adrenocortical disorders. Ann. Intern. Med. 54: 175, 1961. LinkGoogle Scholar5. SAGANPERLOFFDIRAIMONDO LPVC: Studies of the fate of adrenal corticoids in hyper and hypothyroidism. 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Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Endocrine Research Laboratory of the Department of Medicine, The Mount Sinai Hospital, New York, New York.At the time of this study, Dr. Kowal was a Trainee of the National Institutes of Health, United States Public Health Service.Requests for reprints should be addressed to Jerome Kowal, M.D., The Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHypothalmic-pituitary-adrenal function in thyroid disorders: Effects of methopyrapone infusion on plasma corticosteroids 1 July 1963Volume 59, Issue 1_Part_1Page: 79-83KeywordsAdrenocorticotropic hormoneExcretionHospital medicineHyperthyroidismMedical servicesPrevention, policy, and public healthResearch laboratoriesSteroidsStormsThyroid Issue Published: 1 July 1963 PDF DownloadLoading ...