tbuckley/cabot-search huggingface dataset:
Bromocriptine and uterine neoplasia
Authors: H. Jacobs, J D Hutton
Journal: BMJ (1977)

ipecacuanha (mean time to Voomit, 17 min) and a further 20% vomited after the second dose of the syrup (mean time to vomit, 36 min after first dose), making a total response of 960,, in this group.There was no significant difference in the proportion of patients vomit- ing between the 15-and 30-ml dose groups.Our results indicate that syrup of ipecacuanha is indeed an effectivxe treatment for poisoning in adults and must be regarded as a useful and often more convenient and safer alternative to gastric lavage.It should, how- ever, be emphasised that ipecacuanha syrup is contraindicated for comatose patients and also for those patients who have ingested corrosive substances or petroleum distillates.
Typhoid Fever in Detroit
Authors: John E. Clark
Journal: JAMA (1910)

<h3>To the Editor:—</h3> The article inThe Journal, October 8, on our water-supply, coming from the chief organ of the physicians of the United States, demands attention. From such an authority one would expect the most careful consideration and conclusions drawn, not from analogy or hypothesis but from scientific examinations of the water, its source and surroundings and the vital statistics affected by its supply. In other words, it is essential to make a careful and thorough "sanitary survey." May I be permitted to doubt the thoroughness with which this has been accomplished by the commissioner of The Journal? The general tenor of his article is a condemnation of Detroit's water-supply and an intimation that we are in immediate danger of a typhoid epidemic. The belief in this menace to our health is not based on the health of the city, the results of a chemical and bacteriologic examination of
Sebum output as a factor contributing to the size of facial pores
Authors: M. Roh, M. Han, D. Kim, K. Chung
Journal: British Journal of Dermatology (2006)

Many endogenous and exogenous factors are known to cause enlarged pilosebaceous pores. Such factors include sex, genetic predisposition, ageing, chronic ultraviolet light exposure, comedogenic xenobiotics, acne and seborrhoea. This study was an attempt to determine the factors related to enlarged pores.To assess the relationship of sebum output, age, sex, hormonal factors and severity of acne with pore size.A prospective, randomized, controlled study was designed. A total of 60 volunteers, 30 males and 30 females, were recruited for this study. Magnified images of pores were taken using a dermoscopic video camera and measured using an image analysis program. The sebum output level was measured with a Sebumeter.Using multiple linear regression analysis, increased pore size was significantly associated with increased sebum output level, sex and age. Among the variables, sebum output level correlated most with the pore size followed by male sex. In comparing male and female participants, males had higher correlation between the sebum output level and the pore size (male: r = 0.47, female: r = 0.38). Thus, additional factors seem to influence pore size in females. Pore size was significantly increased during the ovulation phase (P = 0.008), but severity of acne was not significantly associated with the pore size.Enlarged pore sizes are associated with increased sebum output level, age and male sex. In female patients, additional hormonal factors, such as those of the menstrual cycle, affect the pore size.
High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension
Authors: Nambirajan Sundaram, Anitaben Tailor, Laurel Mendelsohn, Janaka Wansapura, Xunde Wang, Tomoyasu Higashimoto, Michael W. Pauciulo, William Gottliebson, Vijay K. Kalra, William C. Nichols, Gregory J. Kato, Punam Malik
Journal: Blood (2010)
AN EMERGENCY UNIVERSAL SPLINT FOR FRACTURED LONG BONES
Authors: H. C. Masland
Journal: JAMA (1922)

In former publications,<sup>1</sup>I have described a series of splints for the absolute reduction and fixation of acute fractures in the continuity of the major long bones. These splints are the implements of the surgeon. The splints illustrated in Figure 1 and 2 are not in any way to be considered as substitutes for those previously described, nor are they for the permanent treatment of fractures. They are for use in the factory, mine, patrol wagon, etc. They are for emergency use to give comfort during the delay that occurs while the patient is being transported to the hospital or other place where he receives corrective treatment. <h3>FEATURES OF SPLINTS</h3> The one splint set is adjustable so that fixation of a fracture of any of the major long bones may be secured. The metal strips are bendable to conform to the shoulder or buttock, yet of ample strength for
Vectorcardiographic Residua of Inferior Infarction
Authors: IRWIN HOFFMAN, ROBERT C. TAYMOR, ABRAHAM GOOTNICK
Journal: Circulation (1964)

Seventy-eight patients with well-documented inferior infarction were studied by the Frank vectorcardiographic technic. The commonest residual was superior and leftward orientation of the early forces that moved clockwise in the frontal projection. Quantitative data on the duration, magnitude, and leftward sweep of these forces are presented. In 52 cases, the entire frontal loop was clockwise. When sagittal loop reversal, partial or total, ocurred in this group, a high correlation with associated anterior infarction or left ventricular enlargement was noted. In 24 patients, the returning frontal limb was deformed due to upward bowing. When anterior forces were well preserved in the presence of this deformity, a characteristic "pollywog" shape in the sagittal loop resulted. Conduction defects were twice as common in the cases with mid-loop frontal deformity as in the cases without such defects. Anterior forces of prominent voltage and prolonged duration were noted in 19 cases. Quantitative data on these cases, presumably reflecting associated posterior infarction, are presented. The vectorcardiographic residua of inferior infarction may be classified according to rotational characteristics of the frontal and sagital loops. Classification may be of value in providing clues to associated anterior disease, left ventricular enlargement, and conduction defect.
Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients
Authors: Laura Rossi, Michela Leveri, Chiara Gritti, Annalisa De Silvestri, Claudio Zavaglia, Laura Sonzogni, Laura Silvestri, Emilio Civardi, Mario U Mondelli, Enrico M Silini
Journal: Journal of Hepatology (2003)
Glycosylated Serum Protein Levels Assayed With Highly Sensitive Immunoradiometric Assay Accurately Reflect Glycemic Control of Diabetic Patients
Authors: Amirav Gordon, Benjamin Glaser, Moshe Wald, Graziano Del Rio, Luciano Della Casa, Jack Gross, Erol Cerasi
Journal: Diabetes Care (1992)

Objective To develop a sensitive and reliable immunoreadiometric assay to measure glycosylated lysine residues on serum proteins (GSP) and to evaluate its efficacy in monitoring glycemic control. Research Design The effect of acute and chronic in vitro and in vivo changes in glucose levels on GSP concentration was evaluated. GSP determinations from insulin-dependent diabetic (IDDM) patients, non-insulin-dependent diabetic (NIDDM) patients, and control subjects were correlated with other indices of glycemic control. Results The GSP levels were unaffected by acute glucose changes after food or intravenous glucose administration but increased during storage at−20°C due to in vitro glycosylation by endogenous glucose. Immediate acidification of the serum prevented this, permitting long-term storage despite high ambient glucose levels. In randomly selected diabetic patients, 96% of GSP values were greater than the mean +3SD of nondiabetic control subjects. In diabetic patients, GSP levels correlated with mean plasma glucose concentrations (Kendall correlation statistics 0.47, P &amp;lt;0.001), fasting plasma glucose levels (Kendall statistics 0.42, P &amp;lt;0.001), and glycosylated hemoglobin (GHb, Kendall statistics 0.30, P &amp;lt;0.005). Induction of near-normal glycemia in poorly controlled NIDDM patients reduced GSP levels with a slope consistent with a half time of disappearance of 4.7 ± 0.4 days. GSP levels remained elevated in 6 of 10 well-controlled NIDDM patients, despite normal GHb concentrations. Chronic hypoglycemic states, like pregnancy and hyperinsulinemic hypoglycemia, were associated with significantly low GSP levels. Conclusion We describe a reproducible and sensitive immunoradiometric assay for GSP that closely reflects the degree of glycemic control in diabetic patients. Further studies are needed to determine whether this assay may be useful in screening for glucose intolerance or gestational diabetes.
Letter: Treatment of genital herpes.
Authors: P H Gosling
Journal: BMJ (1974)

quantities by the Radiochemical Centre for use by investigators, who are continually evaluating its properties.'We have had the opportunity of testing this2 and comparing it with the silicate and with yttrium-90 citrate from France.The silicate consistently gave good retention in the knee, equivalent to that previously found with the resin col- loid, while the ferric hydroxide-based col- loid and the citrate were less well retained in the knee.In addition the citrate was associated with early lymph node uptake of considerable amounts of radioisotope.We have also analysed the chromosomal damage noted after treatment with these four radiocolloids and have found a low rate of chromosomal damage-equivalent to that after iodine-131 treatment for hyperthy- roidism-with the ferric hydroxide and sili- cate forms of yttrium-90.With the citrate there was considerably more chromosomal damage, roughly equivalent to that found with gold-198.4You mention that there is a reduction of lymph node uptake with hydrocortisone.This is noted only when using gold-198, with which there is a very considerable lymph node uptake of radioactivity.We have attempted the same work with yttrium-90 silicate, but because there is very little lymph node uptake with this latter preparation we have been unable to demonstrate material differences between hydrocortisone-treated patients and control patients in terms of lymph node uptake.-Iam, etc.,
High-sensitivity C-reactive protein level is a significant risk factor for silent cerebral infarction in patients on hemodialysis
Authors: Futoshi Anan, Tsuyoshi Shimomura, Tadayuki Kaku, Koji Kaneda, Masaharu Imagawa, Hiroshi Tsukagawa, Takayuki Masaki, Tomoko Nawata, Hidetoshi Yonemochi, Nobuoki Eshima, Tetsunori Saikawa, Hironobu Yoshimatsu
Journal: Metabolism (2007)
Fast track deportation without access to legal counsel is illegal
Authors: C. Dyer
Journal: BMJ (2010)

The UK government’s policy of fast track removal of some failed asylum seekers, including unaccompanied children, is illegal because it denies them access to justice, the High Court has ruled.

The ruling is a victory for Medical Justice, a charity that provides independent medical and legal advice to detainees in immigration centres, which sought judicial review of the policy.

Medical Justice claimed that the UK Border Agency was increasingly making use of the policy it introduced in March 2007 and extended in January this year. The general policy is to give 72 hours’ …
Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway
Authors: Akihiro Yasoda, Yasato Komatsu, Hideki Chusho, Takashi Miyazawa, Ami Ozasa, Masako Miura, Tatsuya Kurihara, Tomohiro Rogi, Shoji Tanaka, Michio Suda, Naohisa Tamura, Yoshihiro Ogawa, Kazuwa Nakao
Journal: Nature Medicine (2003)
Sex and prognosis in adult acute lymphoblastic leukaemia.
Authors: M Baccarani, D Ruggero, M Gobbi, S Tura
Journal: BMJ (1978)

tricyclic and, if that should fail, of an MAO inhibitor.I have been impressed with the good response of about half of these very severely affected patients to such therapy.Elithorn' stated that migraine is "undeniably a hunting-ground for the drug-happy physician."This, of course, is true, but such a statement should not deter efforts to find an effective treatment for this distressing and persistent disorder.
Bone Lead Levels and Delinquent Behavior
Authors: Edgar J. Schoen
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The article by Dr Needleman and collegues<sup>1</sup>is based on analyzing bone lead by XRF, a method of unproven clinical reliability. An XRF registry has recently been developed by the lead-testing industry in response to increasing reports of poor and highly variable data quality of XRF analyses for industrial use. Analyses for medical studies should have more exacting requirements. Needleman et al stated in their "Methods" that bone lead and psychological studies were done twice, 2 years apart. They indicated that the bone lead results of the first study were not usable (the lead x-ray levels from even the high-lead phantoms were obscured), although in the second study they were more readily "detectable." What does this mean in terms of specificity, sensitivity, and reproducibility? Further, why did the authors only compare the neuropsychological results of the first study with the XRF results of the second study?
Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy
Authors: Yoshinori Takahashi, Tsukasa Hori, Timothy K. Cooper, Jason Liao, Neelam Desai, Jacob M. Serfass, Megan M. Young, Sungman Park, Yayoi Izu, Hong-Gang Wang
Journal: Blood (2013)
CLINICAL OUTCOMES AND LEFT VENTRICULAR FUNCTION AFTER AORTIC VALVE REPLACEMENT OF PATIENTS WITH SEVERE CHRONIC AORTIC REGURGITATION: LONG–TERM FOLLOW–UP DATA
Authors: Chisato Izumi, Masashi Amano, Masako Hayama, Seiko Nakajima, Yodo Tamaki, Makoto Miyake, Hirokazu Kondo, Toshihiro Tamura, Kazuaki Kaitani, Yoshihisa Nakagawa
Journal: Journal of the American College of Cardiology (2013)
TREATMENT OF RHEUMATOID ARTHRITIS WITH AUROTHIOGLYCANIDE (LAURON)
Authors: Robert C. Batterman
Journal: JAMA (1953)

The discovery of cortisone and corticotropin (ACTH) raised considerable hope that the therapy for the rheumatoid state was at hand. An evaluation of the results, however, particularly after prolonged use, is indicative that there is much to be desired. Although the initial improvement is excellent in all but a few patients, the overall effectiveness is disappointing. When the results are analyzed in terms of the therapeutic criteria of the American Rheumatism Association,<sup>1</sup>functional improvement is very good but the degree of improvement in terms of rheumatoid activity is usually grade 2 (major) or 3 (minor) and rarely grade 1 (complete remission). In view of the high relapse rate, severe withdrawal syndrome, and toxicity with prolonged use, Freyberg and associates<sup>2</sup>have recently indicated that they are concerned with the question: "Will treatment with cortisone be worth while for this patient?" Therefore, the therapeutic measures available for the treatment of
Effect of oxitropium bromide on histamine-induced airway goblet cell secretion.
Authors: K Takeyama, J Tamaoki, J Nakata, K Konno
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

To determine whether histamine affects airway goblet cell secretion and, if so, whether cholinergic mechanism is involved, we studied guinea pig airways by a semiquantitative morphometric method. The goblet cell secretion was assessed in histologic sections of the tracheal mucosa stained with Alcian blue and periodic acid-Schiff (PAS) by determining the mucus score, which is inversely related to the magnitude of mucus discharge. Inhaled or intravenously administrated histamine dose dependently decreased the mucus score, an effect that was similarly observed in cartilaginous and muscular portions. Inhalation of the anticholinergic agent oxitropium bromide at doses of 1.5 micrograms and higher greatly attenuated the decrease in mucus score produced by intravenous histamine but not by inhaled histamine. Likewise, cutting of bilateral vagus nerves or atropine abolished intravenous histamine-induced goblet cell secretion. The response of the mucus score to inhaled histamine was abolished by cimetidine, whereas the response to intravenous histamine was reduced by mepyramine but not by cimetidine or thioperamide. These results suggest that inhaled histamine increases airway goblet secretion, probably by stimulating histamine H2-receptors on goblet cells, and that intravenous histamine produces a similar effect through a stimulation of histamine H1-receptor-mediated release of acetylcholine from cholinergic nerve terminals, presumably involving vagal reflex.
Case 48-1973
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Edwin P. Maynard, James J. Galdabini
Journal: New England Journal of Medicine (1973)

Presentation of CaseA 50-year-old man was admitted to the hospital because of fever.Twenty-two years previously bloody diarrhea occurred, and a barium-enema examination showed changes consistent with ulcerative colitis. His symptoms improved but recurred 15 years before entry, and his weight decreased to less than 46 kg. Fourteen years before admission evaluation at this hospital revealed the malabsorption syndrome, and a biopsy of the small intestine disclosed villous atrophy consistent with sprue. A gluten-free diet was prescribed, with control of the diarrhea and a gain in weight. Five years later gastrointestinal bleeding occurred; an exploratory laparotomy revealed no source . . .
Functional Brown Adipose Tissue in Healthy Adults
Authors: Kirsi A. Virtanen, Martin E. Lidell, Janne Orava, Mikael Heglind, Rickard Westergren, Tarja Niemi, Markku Taittonen, Jukka Laine, Nina-Johanna Savisto, Sven Enerbäck, Pirjo Nuutila
Journal: New England Journal of Medicine (2009)

Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
Deletion of<i>IKZF1</i>and Prognosis in Acute Lymphoblastic Leukemia
Authors: Charles G. Mullighan, Xiaoping Su, Jinghui Zhang, Ina Radtke, Letha A.A. Phillips, Christopher B. Miller, Jing Ma, Wei Liu, Cheng Cheng, Brenda A. Schulman, Richard C. Harvey, I-Ming Chen, Robert J. Clifford, William L. Carroll, Gregory Reaman, W. Paul Bowman, Meenakshi Devidas, Daniela S. Gerhard, Wenjian Yang, Mary V. Relling, Sheila A. Shurtleff, Dario Campana, Michael J. Borowitz, Ching-Hon Pui, Malcolm Smith, Stephen P. Hunger, Cheryl L. Willman, James R. Downing
Journal: New England Journal of Medicine (2009)

Despite best current therapy, up to 20% of pediatric patients with acute lymphoblastic leukemia (ALL) have a relapse. Recent genomewide analyses have identified a high frequency of DNA copy-number abnormalities in ALL, but the prognostic implications of these abnormalities have not been defined.We studied a cohort of 221 children with high-risk B-cell-progenitor ALL with the use of single-nucleotide-polymorphism microarrays, transcriptional profiling, and resequencing of samples obtained at diagnosis. Children with known very-high-risk ALL subtypes (i.e., BCR-ABL1-positive ALL, hypodiploid ALL, and ALL in infants) were excluded from this cohort. A copy-number abnormality was identified as a predictor of poor outcome, and it was then tested in an independent validation cohort of 258 patients with B-cell-progenitor ALL.More than 50 recurring copy-number abnormalities were identified, most commonly involving genes that encode regulators of B-cell development (in 66.8% of patients in the original cohort); PAX5 was involved in 31.7% and IKZF1 in 28.6% of patients. Using copy-number abnormalities, we identified a predictor of poor outcome that was validated in the independent validation cohort. This predictor was strongly associated with alteration of IKZF1, a gene that encodes the lymphoid transcription factor IKAROS. The gene-expression signature of the group of patients with a poor outcome revealed increased expression of hematopoietic stem-cell genes and reduced expression of B-cell-lineage genes, and it was similar to the signature of BCR-ABL1-positive ALL, another high-risk subtype of ALL with a high frequency of IKZF1 deletion.Genetic alteration of IKZF1 is associated with a very poor outcome in B-cell-progenitor ALL.
THE METABOLISM OF GLUCOSE IN SKIN MAINTAINED IN TISSUE CULTURE
Authors: PHILIP J. BAILEY
Journal: British Journal of Dermatology (1971)

SUMMARY.— The amount of 14CO2 produced from carbon-14-labelled glucose by cultures of adult mouse skin has been measured. By comparing the recovery of radioactivity in 14CO2 using glucose-1-14C as a substrate with the recovery of activity in 14CO2 using glucose-6-14C as substrate, an estimation of the amount of glucose oxidized through the Krebs cycle and the pentose phosphate shunt was made. Approximately 1–6% of the glucose used was oxidized via the Krebs cycle, whereas 3–5–40% of the glucose passed through the pentose phosphate cycle. The addition of phenazine methosulphate (PMS) to the culture medium increased the 14CO2 output by mouse skin cultures by over 100%. Although PMS increased the rate at which glucose was oxidized through the Krebs cycle the greatest effect was on the pentose phosphate shunt, increasing the amount of glucose metabolized by this pathway to 30% of the total. Treatment of cultures with PMS was found to inhibit lipid synthesis almost completely.
Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse
Authors: Joern R. Steinert, Cornelia Kopp-Scheinpflug, Claire Baker, R.A. John Challiss, Raj Mistry, Martin D. Haustein, Sarah J. Griffin, Huaxia Tong, Bruce P. Graham, Ian D. Forsythe
Journal: Neuron (2008)
TCT-302 Evaluation of the Novel DESolve Myolimus-Eluting Bioresorbable Coronary Scaffold System for Treatment of De Novo Coronary Arteries: Six-Month Optical Coherence Tomography Results from the DESolve FIM Trial
Authors: Daniel Chamie, Jose Costa, Alexandre Abizaid, Mark Webster, James Stewart, Ricardo Costa, John Yan, vinayak bhat, lynn morrison, Sara Toyloy, John Ormiston, Stefan Verheye
Journal: Journal of the American College of Cardiology (2012)