CHLORPROMAZINE (THORAZINE) HEPATITIS: REPORT OF THREE CASES
Authors: HERMAN GOLD
Journal: Annals of Internal Medicine (1955)

Article1 October 1955CHLORPROMAZINE (THORAZINE) HEPATITIS: REPORT OF THREE CASESHERMAN GOLD, M.D., F.A.C.P., FRANK ROSENBERG, M.D., WILLIAM CAMPBELL, M.D.HERMAN GOLD, M.D., F.A.C.P.Search for more papers by this author, FRANK ROSENBERG, M.D.Search for more papers by this author, WILLIAM CAMPBELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-4-745 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChlorpromazine HCl is a 10-(γ-dimethylaminopropyl)-2-chlorophenothiazine HCl introduced in France and England and, more recently, in the United States under the trade name Thorazine, for the treatment of psychiatric disorders, especially agitated and depressed states, acute and chronic alcoholism, nausea and vomiting of diverse etiology, and hiccups, and for the relief of pain as a potentiator of opiates, hypnotics and anesthetics.1-7 Its use has increased tremendously in the last few months, particularly as a tranquilizer. As of March 1, 1955, it was estimated that Thorazine has been used in the United States in over 2,000,000 patients.7Side effects following the use...Bibliography1. LehmanHanrahan HEGE: Chlorpromazine: a new inhibiting agent for psychomotor excitement and manic states, Arch. Neurol. and Psychiat. 71: 227-237, 1954. CrossrefGoogle Scholar2. FriendCummins DGJF: New antiemetic drug: preliminary report, J. A. M. A. 153: 480, 1953. CrossrefMedlineGoogle Scholar3. SadoveLevinRoseSchwartzWitt MSMJRFLFW: Chlorpromazine and narcotics in the management of pain of malignant lesions, J. A. M. A. 155: 626-628, 1954. CrossrefMedlineGoogle Scholar4. Winkelman NW: Chlorpromazine in treatment of neuropsychiatric disorders, J. A. M. A. 155: 18-21, 1954. CrossrefMedlineGoogle Scholar5. FriedgoodRipstein CECB: Chlorpromazine in the treatment of intractable hiccups, J. A. M. A. 157: 309, 1955. CrossrefMedlineGoogle Scholar6. MoyerKentKnightMorrisDizenRogersSpurr JHBRWGMSC: Clinical studies of an antiemetic agent, chlorpromazine, Am. J. M. Sc. 228: 174, 1954. CrossrefMedlineGoogle Scholar7. : Clinical uses of Thorazine (chlorpromazine, S. K. F.), March, 1955, pp. 14-16. Google Scholar8. LemireMitchell RERA: Regurgitation-type jaundice associated with chlorpromazine administration, Clin. Res. Proc. 3: 23, 1955. Google Scholar9. ZatuchniMiller JG: Jaundice during chlorpromazine therapy, New England J. Med. 251: 1003, 1954. CrossrefMedlineGoogle Scholar10. Van OmmenBrown RACH: Obstructive-type jaundice due to chlorpromazine (Thorazine), J. A. M. A. 157: 321, 1955. CrossrefMedlineGoogle Scholar11. Gambescia J: Personal communication. Google Scholar12. AzimaOgle HW: Effects of largactil in mental syndromes, Canad. M. A. J. 71: 116, 1954. MedlineGoogle Scholar13. MoyerKinross-WrightFinney JHVRM: Chlorpromazine as a therapeutic agent in clinical medicine, Arch. Int. Med. 95: 202, 1955. CrossrefGoogle Scholar14. AlmadenRoss PJSW: Jaundice due to methyltestosterone therapy, Ann. Int. Med. 40: 146, 1954. LinkGoogle Scholar15. GargillLesses SLMF: Toxic reactions to thiouracil: report of cases with one fatality, J. A. M. A. 127: 890, 1945. CrossrefGoogle Scholar16. HangerGutman FMAB: Postarsphenamine jaundice: apparently due to obstruction of intrahepatic biliary tract, J. A. M. A. 115: 263, 1940. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 18, 1955.From the Departments of Medicine and Pathology, Chester Hospital, Chester, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExaggerated cholestasis and hepatic fibrosis following simultaneous administration of chlorpromazine and sodium valproateCholestatischer IkterusPhenothiazine und Azaphenothiazine als HeilmittelIntrahepatic cholestasis following administration of chlorpropamideDRUG-INDUCED HEPATIC INJURY*HANS POPPER, M.D., F.A.C.P., FENTON SCHAFFNER, M.D., F.A.C.P.Liver cell necrosis in chlorpromazine jaundice (allergic cholangiolitis)Prolonged Jaundice (Over Three Months) Occurring During Chlorpromazine AdministrationChlorpromazine jaundiceIntrahepatic Cholestasis (“Cholangiolitis”)Diseases of Medical Progress 1 October 1955Volume 43, Issue 4Page: 745-757KeywordsChlorpromazineHepatitisHepatitis EHospital medicineHydrochloric acidIngestionNauseaOpiatesPhosphatasesVomiting Issue Published: 1 October 1955 PDF downloadLoading ...