Bronchopulmonary Lavage in Normal Subjects and Patients with Obstructive Lung Disease
Authors: T. N. FINLEY
Journal: Annals of Internal Medicine (1967)

Article1 April 1967Bronchopulmonary Lavage in Normal Subjects and Patients with Obstructive Lung DiseaseT. N. FINLEY, M.D., E. W. SWENSON, M.D., W. S. CURRAN, M.D., G. L. HUBER, M.D., A. J. LADMAN, PH.D.T. N. FINLEY, M.D., E. W. SWENSON, M.D., W. S. CURRAN, M.D., G. L. HUBER, M.D., A. J. LADMAN, PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-4-651 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEndobronchial lavage for the diagnosis and treatment of alveolar proteinosis has been used with apparent success (1, 2). Ramirez-R., Kieffer, and Ball (1) have suggested that endobronchial lavage might be useful in any condition where there is an "abnormal accumulation of material in bronchioles and alveoli," such as alveolar microlithiasis,Pneumocystis cariniipneumonia, hyaline membrane disease, chemical pneumonias, certain types of viral pneumonias, unremittent bronchial asthma, and bronchiolectasis. A controversy (3, 4), however, has arisen over the possibility of damage to normal lung tissue by saline introduced in this fashion. Several studies (5, 6) reported nolong-termadverse effect of...References1. RAMIREZ-R.KIEFFERBALL JRFWC: Bronchopulmonary lavage in man. Ann. Intern. Med. 63: 819, 1965. LinkGoogle Scholar2. NICHOLASAUCHINCLOSSRUDOLPH JJJHL: Pulmonary alveolar proteinosis. A case with improvement after a short course of endobronchial instillations of heparin. Ann. Intern. Med. 62: 358, 1965. LinkGoogle Scholar3. VANDAM LD: Aspiration of gastric contents in the operative period. New Eng. J. Med. 273: 1206, 1965. CrossrefMedlineGoogle Scholar4. RAMIREZ-R. J: Tracheobronchial lavage. New Eng. J. Med. 274: 469, 1966. CrossrefGoogle Scholar5. KYLSTRA JA: Lavage of the lung. Acta Physiol. Pharmacol. Neerl. 7: 163, 1958. MedlineGoogle Scholar6. SALISBURYBRIGGSHAMELCROSSRIEBEN PFJNNDCEPA: Pulmonary lavage: the use of lung, in situ, as an artificial kidney. Trans. Amer. Soc. Artif. Intern. Organs 5: 32, 1959. Google Scholar7. SIMENSTADGALWAYMACLEAN JOCFLD: The treatment of aspiration and atelectasis by tracheobronchial lavage. Surg. Gynec. Obstet. 115: 721, 1962. MedlineGoogle Scholar8. JOHNSONPERMUTTSIPPLESALEM JWSJHES: Effect of intra-alveolar fluid on pulmonary surface tension properties. J. Appl. Physiol. 19: 769, 1964. CrossrefMedlineGoogle Scholar9. HUBERFINLEY GLTN: Effect of isotonic saline on alveolar architecture. Anesthesiology 26: 252, 1965. CrossrefGoogle Scholar10. HUBEREDMUNDSFINLEY GLLHTN: Acute effect of saline lung washing on pulmonary mechanics and morphology. Surg. Forum 17: 113, 1966. MedlineGoogle Scholar11. MORGANFINLEYFIALKOW TETNH: Comparison of the composition and surface activity of "alveolar" and whole lung lipids in the dog. Biochem. Biophys. Acta 106: 403, 1965. CrossrefMedlineGoogle Scholar12. COOPERBERGSCHWARTZ AAJ: The diagnosis of disseminated histoplasmosis from marrow aspiration. Ann. Intern. Med. 61: 289, 1964. LinkGoogle Scholar13. MACKLIN CC: The pulmonary alveolar mucoid film and the pneumonocytes. Lancet 1: 1099, 1954. CrossrefGoogle Scholar14. CLEMENTS JA: Surface tension in the lungs. Sci. Amer. 207: 120, 1962. CrossrefMedlineGoogle Scholar15. BUCKINGHAMHEINEMANNSOMMERSMCNARY SHOSCWF: Phospholipid synthesis in the large pulmonary alveolar cell. Amer. J. Path. 48: 1027, 1966. MedlineGoogle Scholar16. HATASANAKAMURA KT: Electron microscopic observations of lung alveolar epithelial cells of normal young mice, with special reference to formation and secretion of osmiophilic lamellar bodies. Z. Zellforsch. 68: 266, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: T. N. FINLEY, M.D.; E. W. SWENSON, M.D.; W. S. CURRAN, M.D.; G. L. HUBER, M.D.; A. J. LADMAN, PH.D.Affiliations: Albuquerque, New MexicoFrom the Departments of Medicine and Anatomy, University of New Mexico School of Medicine, Albuquerque, N. M.This study was supported in part by research grants HE 04191-02 and GM 14435-01, the National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to T. N. Finley, M.D., University of New Mexico School of Medicine, Albuquerque, N. M. 87106. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySafety and Tolerability of Comprehensive Research Bronchoscopy in Chronic Obstructive Pulmonary Disease. 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