tbuckley/cabot-search huggingface dataset:
THERMOVIBRASSAGE: A NEW METHOD OF TREATMENT.PRELIMINARY REPORT.
Authors: FREDERIC WADE HITCHINGS
Journal: JAMA (1906)

Nearly a year ago it occurred to me that if it were possible to give a treatment in which the effect of either dry or moist heat of any desired intensity could be added to that of mechanical vibration the value of the latter might be greatly modified, and perhaps markedly increased. Most of the available time since has been devoted to perfecting apparatus for attaining this end, and not only has this been successfully done, but enough clinical and other data have been accumulated to warrant a preliminary statement. <h3>APPARATUS DESCRIBED.</h3> In brief, what has been done has been to insert a resistance coil into the same space ordinarily occupied by a ball vibratode. The case surrounding the coil is of metal, and screws on the vibrator shaft just as an ordinary vibratode screws on. From a plug switch on the bale of the vibrator a short cable passes
Abstract P3-15-04: The Clinical Course of Metastatic Breast Cancer Patients with a Congestive Heart Failure after an Epirubicin-Based Treatment
Authors: M Ryberg, DL Nielsen, MT Jensen, G Nielsen, PK. Andersen
Journal: Cancer Research (2010)

Abstract Background. Patients treated with epirubicin are at risk for the development of congestive heart failure (CHF). However, only limited data are available, which is describing the outcome for these patients. Materials and methods. The patients were recruited consecutively from 1,097 anthracycline-naïve patients with metastatic breast cancer, who were admitted to Herlev Hospital from November 1983 - November 2003 for an epirubicin-based chemotherapy. No patients had a history of heart disease. The outcome of 125 metastatic breast cancer patients, with a CHF Class ≥ II according to New York Heart Association (NYHA) guidelines after an epirubicin-based treatment, was performed retrospectively. Univariate ordinal logistic regression was used to study the association between NYHA class at time of CHF (II, III or IV) and possible risk factors. Two multiple Cox regression analyses (events: mortality of cardiotoxicity and mortality of other causes) were performed to evaluate the risk of cardiac death. Results. CHF was developed within a median time from cessation of epirubicin on 3 months (range 0 to 66.7 months). The distribution of patients in the NYHA class II, III, IV and NYHA class ≥2 was; 35 patients (28%), 38 patients (30.4%), 39 patients (31.2%) and 13 patients (10.4%), respectively. No predictive factors, including increasing cumulative dose of epirubicin, co-morbidities and age had an influence on the severity of CHF. The median survival of all patients was 7.3 months (range 0.01 to +121.1 months). Deaths caused by CHF occurred in 27 patients (21.6%) in a median time on 1.2 months (range 0 - 77 months), including 6 patients (4.8%) dying of cardiac failure &amp;lt; 10 days after the diagnosis. Only the NYHA class patient had was the only risk factor for dying of CHF (p = 0.0003). Compared to patients in NYHA class II and III, the risk of cardiac death in patients with NYHA class IV was increased with 93% and 74%, respectively. Survival in patients with stable CHF was comparable to other patients with metastatic breast cancer. Discussion. Although the information is obtained retrospectively during a period of twenty years; the study is important, as only limited information is available on the course of CHF patients. The study showed that the risk of cardiac death were closely related to the degree of cardiac toxicity as the risk of cardiac death was 93% or 74% higher for patients in NYHA class IV than for patients in NYHA class II or III. Moreover, the outcome for the patients when CHF is stabilized can be expected to be as patients without CHF. Furthermore, no predictive factors were identified, including increasing cumulative dose of epirubicin for the severity of cardiotoxicity developed. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-15-04.
Unusual Scintigraphic Pattern for Postsurgical Bile Leak
Authors: MARNI GROSSFELD, DARLENE FINK-BENNETT
Journal: Clinical Nuclear Medicine (1993)

The use of Tc-99m DISIDA for imaging of bile leaks following biliary tract surgery has been well documented. Scintigraphic patterns demonstrating extra-biliary tract radiotracer accumulation include free tracer in the peritoneal cavity, as well as accumulations of tracer in the right paracolic gutter, gallbladder fossa, and over the surface of the liver. A scintigraphic pattern of bile leak is presented.
NCI Board Votes to Keep Mammography Guidelines
Authors: Charles Marwick
Journal: JAMA (1993)

GUIDELINES for routine mammographic screening of younger women should stand—for the time being at least. By an overwhelming majority (only one person opposed and one abstained), the National Cancer Advisory Board approved a motion that says, despite the controversy over the effectiveness of mammography in women under 50 years of age (<i>JAMA</i>. 1993;270:2444-2450), the board recommends that the National Cancer Institute (NCI) defer making any changes in the current guidelines regarding mammographic breast cancer screening. The board was considering a proposal that the current guidelines, which recommend screening every 1 to 2 years in this younger age group, be replaced with a discussion with one's physician on the need for screening based on the risk factors for breast cancer. The board's action, which is advisory to NCI Director Samuel Broder, MD, was taken only after a spirited discussion by board members over a recommendation that, since mammographic screening of women
Endobronchial Ultrasound Doppler Image Features Correlate with mRNA Expression of hif1-α and vegf-c in Patients with Non–Small-Cell Lung Cancer
Authors: Takahiro Nakajima, Takashi Anayama, Terumoto Koike, Masato Shingyoji, Lianne Castle, Hideki Kimura, Ichiro Yoshino, Kazuhiro Yasufuku
Journal: Journal of Thoracic Oncology (2012)
"Matching Program" for Manuscripts
Authors: HOWARD M. SHAPIRO
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 April 1973"Matching Program" for ManuscriptsHOWARD M. SHAPIRO, M.D.HOWARD M. SHAPIRO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-4-615_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A letter by Abram ("Authors of Academia, Unite!" Ann Intern Med 77:153-154, 1972) suggested that publication of papers would be expedited by authors submitting simultaneously to several journals.You criticize this practice as leading to an unnecessary increase in the work done by reviewers; this need not be so. For example, an author who finds he must submit a manuscript tonjournals will have it seen by an average of2nreviewers before it is accepted. Should he submit tomjournals at once (wheremis less thann), the probability of acceptance is approximately... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HOWARD M. SHAPIRO, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1973Volume 78, Issue 4Page: 615-615 ePublished: 1 December 2008 Issue Published: 1 April 1973 PDF downloadLoading ...
Monoplace Hyperbaric Oxygen Therapy for Gas Gangrene
Authors: Dennis L. Fowler
Journal: JAMA (1977)

Untreated gas gangrene is a fulminating infection that can lead to extensive tissue necrosis and death. Hyperbaric oxygen, when used with antibiotics and surgical debridement, can lead to decreased mortality. Nine patients with gas gangrene proven by positive clostridial cultures have been treated at St Luke's Hospital of Kansas City with a mortality of 11.1%. A case of gas gangrene developing from a perirectal abscess is presented. (<i>JAMA</i>238:882-883, 1977)
Early Involvement of the Phosphatidylinositol 3-Kinase/Akt Pathway in Lung Cancer Progression
Authors: Pierre P. Massion, Peter M. Taflan, Yu Shyr, S. M. Jamshedur Rahman, Pinar Yildiz, Bashar Shakthour, Mary E. Edgerton, Matthew Ninan, Jeremiah J. Andersen, Adriana L. Gonzalez
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Signaling through the phosphatidylinositol 3-kinase (PI3-kinase) pathway has been associated with lung tumorigenesis. We examined the association between gene copy number of the PI3-kinase catalytic subunit alpha (PIK3CA) and phosphorylated Akt expression in invasive and preinvasive lung cancers. We sought to determine at what stage of tumor development gene copy number increase or phosphorylated Akt overexpression might affect tumor development. We assessed PIK3CA gene copy number by fluorescence in situ hybridization and expression of phosphorylated Akt by immunohistochemistry in 242 invasive and 43 preinvasive lung cancers and correlated our findings with clinical outcome. The PIK3CA was amplified in 70% of squamous carcinomas, 38% of large cell carcinomas, 19% of adenocarcinomas, and 67% of small cell lung cancers. Phosphorylated Akt overexpression was frequently observed, and strongly so in 12 to 17% of lung cancers depending on nuclear or cytoplasmic localization. Neither PIK3CA gene copy number nor phosphorylated Akt protein expression had prognostic significance. In preinvasive lesions, amplification of the PIK3CA and overexpression of phosphorylated Akt were associated with severe dysplasia and each other. These observations suggest frequent and early involvement of the PI3-kinase pathway in lung cancer.
Combining HSP90 Inhibition with Standard Therapies for HER2 Positive Breast Cancer.
Authors: Z. Qadir, Z. Qadir, J. Crown, J. Crown, M. Jensen, M. Clynes, D. Slamon, N. O'Donovan
Journal: Cancer Research (2009)

Abstract Background: HSP90 is required for the stability and activity of HER2 and downstream proteins, such as Akt, which play a key role in cell survival. We aimed to assess the anti-tumor effects of the HSP90 inhibitor NVP-AUY922 in HER-2 positive breast cancer cell lines.Methods: HER2 positive breast cancer cell lines with varied sensitivity to trastuzumab (Sensitive: BT474, SKBR3, MDA-MB-361; acquired resistance: BT474Res, SKBR3Res; innate resistance: HCC1419, HCC1954, MDA-MB-453) were treated with the HSP90 inhibitor NVP-AUY922 (Novartis) and trastuzumab. IC50s were determined using the acid phosphatase assay. HER2, Akt and HSP90 levels were determined by immunoblotting after treatment with NVP-AUY922. Combinations of NVP-AUY922 with trastuzumab were tested in BT474, BT474Res, SKBR3, SKBR3Res, HCC1954, and MDA-MB-361 cells. Combinations with docetaxel, cisplatin and 5'-deoxy-5-fluorouridine (5-DFUR) were tested in BT474, SKBR3, HCC1954, MDA-MB-453 and MDA-MB-361 cells.Results: All of the HER2 positive cells were sensitive to NVP-AUY922, with IC50s ranging from 5.5 to 16.4 nM and NVP-AUY922 treatment reduced HER2 and Akt levels in a dose dependent manner. Combined treatment with NVP-AUY922 (10 nM) and trastuzumab (10 nM) showed significantly greater inhibition of growth than either trastuzumab or NVP-AUY922 alone in BT474 and BT474Res cell lines (p&amp;lt;0.005). In SKBR3, SKBR3Res, HCC1954, MDA-MB-453 and MDA-MB-361 cells, dual treatment with NVP-AUY922 and trastuzumab did not significantly increase response compared to NVP-AUY922 alone (Table 1). Combinations of docetaxel, cisplatin or 5-DFUR with NVP-AUY922 were antagonistic in all cell lines tested (CI values &amp;gt;1).Conclusions: This study demonstrates that NVP-AUY922 has anti-tumour activity in HER2 positive breast cancers regardless of sensitivity to trastuzumab. The antagonistic interactions observed for combinations of NVP-AUY922 with chemotherapy do not favour clinical evaluation of concurrent administration of NVP-AUY922 with chemotherapy. However, alternative scheduling or combinations with other targeted therapies warrants further investigation.Table 1: Percentage growth in response to NVP-AUY922 and trastuzumab. BT474BT474ResSKBR3SKBR3ResHCC1954MDA-MB-361Trastuzumab53.3 +/- 4.990.4 +/- 7.669.5 +/- 16.179.5 +/- 8.2102.9 +/- 15.558.4 +/- 3.3AUY92255.0 +/- 1.192.6 +/- 11.933.3 +/- 9.719.1 +/- 6.152.2 +/- 13.88.2 +/- 6.2Tras+AUY92222.0 +/- 2.3*59.7 +/- 17.5*30.6 +/- 7.518.3 +/- 4.347.2 +/- 3.42.5 +/- 2.2 Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5055.
Eunuchism of Squirrels.
Authors: Samuel J. Fort
Journal: JAMA (1898)

Ellicott City, Md., Feb. 25, 1898. <h3>To the Editor:</h3> —The theory has been advanced by many hunters I have met that during the absence of the mother squirrel, the young utilize the male appendages as teats and in their kind effort to produce something that is not there, cause in time an atrophy of the organs. Personally, though I have killed many squirrels, I have never seen a male minus his testicles, due, probably to the fact that I have never searched specimens for their presence or absence, save as I skinned them for use on the table. I very much doubt the theory of the older males castrating the younger ones; there is no reason why this should be done, and betrays more sense than the animal's gray matter or habits would warrant. A study of the incisor teeth of the squirrel would also suggest a difficulty in performing
Physicians' Guide to the Internet
Authors: Gregory F. Pratt
Journal: JAMA (1996)

As stated in the preface,<i>Physicians' Guide to the Internet</i>is offered to help "break down the barriers that face the health community in taking advantage of the Internet information explosion." The author is well known in biomedical Internet circles. Since 1990, he has voluntarily organized health-related Internet resources into what is commonly called the Hancock List. In addition, he manages e-mail-based discussion lists focusing on computerized patient records (CPRI-L, the Computer-Based Patient Records Institute List) and online health resources (HMATRIX-L). To help the uninitiated, the book opens with 20 pages of Internet essentials. Necessary computer hardware, software, and means of Internet access are fundamentally described, as are various Internet components (eg, electronic mail, telnet, and gopher). This is followed by listings for approximately 500 Internet resources drawn from the much larger Hancock List. Encompassing 80% of the book's content, the resources are organized into broad categories, such as diseases/disorders,
Abstract 5537: Ubiquitination of RRM1 by Ring1B (RNF2) promotes its degradation and nuclear export
Authors: Yingtao Zhang, Xin Li, Zhengming Chen, Scott Freeman, Jun Zhou, Gerold Bepler
Journal: Cancer Research (2011)

Abstract RRM1 (ribonucleotide reductase M1) is a key enzyme involved in deoxyribonucleotide (dNTP) synthesis and DNA damage repair. It also plays a critical role in acquired resistance to the chemotherapy drug gemcitabine, which directly inhibits the RR holoenzyme. Despite its significant importance, however, the mechanisms that control RRM1 abundance and subcellular localization are unclear. We have identified a ubiquitin E3 ligase, Ring1B (RNF2), as an RRM1-associated protein in a yeast two-hybrid screen. RRM1 interacts with Ring1B both in endogenous and exogenous situations. Additionally, immunofluorescent staining has shown that Ring1B clearly co-localized with RRM1 in a pattern of diffuse nuclear speckles. We found that the protein level of RRM1 is regulated by a proteasome-mediated degradation pathway. Ring1B induces poly-ubiquitination of RRM1 in vivo. Formation of poly-ubiquitin chains on RRM1 is through both Lys48 (K48) and Lys63 (K63) of the ubiquitin. Our study demonstrates that the cytoplasmic fraction of RRM1 was increased upon Ring1B or ubiquitin overexpression, but significantly decreased after nuclear export inhibition by leptomycin B (LMB). This indicates that RRM1 ubiquitination promotes the translocation of RRM1 from the nucleus to the cytoplasm. We also show that hydrogen peroxide (H2O2) promotes the degradation of RRM1 in dose and time-dependent manners. H2O2 can increase the poly-ubiquitination of RRM1, which suggests that RRM1 ubiquitination may participate in cellular responses to oxidative stress-induced DNA damage repair. In summary, our data propose that Ring1B-induced ubiquitination regulates RRM1 activity through RRM1 degradation and nuclear export. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5537. doi:10.1158/1538-7445.AM2011-5537
SOME PROBLEMS OF PRESBYOPIA.
Authors: GEORGE M. GOULD
Journal: JAMA (1905)

When I began practice I did as I had been taught regarding the correction of presbyopia. Text-books, teachers, and general custom agreed that presbyopia began sometime after forty, and that no mydriatic was needed in such patients. There was a rough rule wandering about that plus spherical lenses of one diopter were needed in forty-five-year-old patients, twos at fifty, threes at sixty. This was about the time of the "Punch, Brother, Punch with care, a blue slip ticket for a five-cent fare, etc." Actual dealing with presbyopic patients soon brought me up sharp. Rules like those of the street car conductors would not work out in the oculist's office. If any rules at all were admissible they had to be of a different kind from those of the text-books; in some ways far more definite, in others more indefinite. Some of these cautions
Normal thoracoabdominal motions. Influence of sex, age, posture, and breath size.
Authors: J A Verschakelen, M G Demedts
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The purpose of this study was to assess normal values of thoracoabdominal motions (TAM) during spontaneous breathing and vital capacity (VC) maneuvers in relation to sex, age, and body position. For this, 120 healthy subjects from 10 to > 60 yr old were studied using the respiratory inductive plethysmograph (Respitrace). The volume-motion coefficients obtained during quiet breathing for the rib cage (RC) were almost twice those for the abdomen (ABD) and were not influenced by sex or age and also not by posture, except for the increased ABD coefficients in the supine posture (p < 0.05). Under most conditions RC motion predominated over ABD motion, except quiet breathing in the supine position. Sex-related differences in TAM were not found during quiet breathing, yet during VC maneuvers the women were slightly more RC breathing (p < 0.01). Age-related differences were also only significant during VC maneuvers: men of more than 50 yr old especially became less RC breathing. Posture had a very significant effect (p < 0.001) during quiet breathing as well as during VC maneuvers: the RC predominance was greatest in the standing posture and least in the supine posture. During VC maneuvers the subjects became more RC breathers than during quiet breathing (p < 0.001). The X-Y coordinates of RC motion (on the Y axis) versus ABD motion (on the X axis) showed under all conditions a counterclockwise looping during the breathing cycle: the looping was elliptic during quiet breathing but was more irregular and variable during VC maneuvers, and this also depended on body position.(ABSTRACT TRUNCATED AT 250 WORDS)
CD4-Pseudomonas exotoxin conjugates delay but do not fully inhibit human immunodeficiency virus replication in lymphocytes in vitro.
Authors: H Tsubota, G Winkler, H M Meade, A Jakubowski, D W Thomas, N L Letvin
Journal: Journal of Clinical Investigation (1990)

The CD4 molecule is a high affinity receptor for the human immunodeficiency virus (HIV) envelope glycoprotein (gp160 or gp120). This glycoprotein is expressed on the surface membrane of cells infected with HIV. It has, therefore, been suggested that a soluble form of CD4 might be used as a targeting agent to deliver toxins selectively to cells infected with HIV. We demonstrate that CD4-Pseudomonas exotoxin A (PE) conjugates inhibit the proliferation of gp160-transfected Chinese hamster ovary cells and block HIV replication in virus-infected H9 cells. However, this inhibition of HIV replication appears to be incomplete since virus replication occurs following removal of the toxin conjugates from these cultures. Moreover, CD4-PE conjugates delay but do not inhibit HIV replication in human peripheral blood lymphocytes. These studies suggest that such conjugates should be assessed only as potential adjunctive therapies in the acquired immunodeficiency syndrome.
Influenza immunization in elderly people.
Authors: D S Sloan
Journal: BMJ (1993)

Cost-utility analysisEDrrOR,-In his article on cost-utility analysis Ray Robinson discusses the quality life year (QALY) but only briefly acknowledges its conceptual and practical shortcomings.'It is unfortunate that prominence is given to the QALY: yet again a table listing costs per QALY shows treatments for renal failure in an unfavourable light.I wish to comment on the cost quoted for erythropoietin for patients receiving dialysis.
Lack of Glucagon Receptors in Morris Hepatoma 7800
Authors: Marisabel Mourelle, Marcos Rojkind
Journal: Hepatology (1984)

When compared to normal liver membranes, purified plasma membranes of regenerating liver and Morris hepatomas contain low but variable capacities to bind glucagon. This property is inversely related to the capacity of the isolated hepatocytes to bind to heterologous biomatrix glycoproteins. Since these parameters are characteristic of the proliferative state of the cells, it was important to further study the glucagon receptor protein and stimulation of adenylate cyclase activity. Our results show that 125I-iodinated plasma membranes obtained from normal liver contain three molecular species (117000, 98000, 86000 molecular weight) that can be eluted specifically with glucagon from a sepharose-glucagon affinity column. These proteins contain the putative glucagon receptor since binding of 125I- iodoglucagon is increased 150-fold as compared to unfractionated membranes. Plasma membranes obtained from Morris hepatoma (7800) and liver of chemically hepatectomized rats do not bind glucagon and lack these proteins. After inactivation with N-ethylmaleimide of the adenylate cyclase activity of the normal plasma membranes, they were fused with membrane of the hepatoma. The hybrid membranes showed 60% recovery of glucagon-stimulated cyclase activity. These results suggest that the plasma membranes of the proliferating liver cells do not contain receptor protein but have intact regulatory and catalytic subunits of the adenylate cyclase system.
Lethal malformations and perinatal mortality: a 10 year review with comparison of ethnic differences.
Authors: I D Young, M Clarke
Journal: BMJ (1987)

During 1976 to 1985 perinatal mortality in Leicestershire decreased from 21 to 9.5 per 1000 births. Throughout this period the incidence of lethal malformations, excluding neural tube defects, remained relatively constant at around 1.8 per 1000 births. Analysis of the malformations present in 201 lethally malformed babies showed that 147 (73%) had a disorder carrying a recurrence risk of 1% or greater. Only 7% of these malformations might have been predicted from the family history or advanced maternal age. The incidence of lethal malformations was significantly increased in the Asian population, largely because of an excess of autosomal recessive disorders. The contribution of lethal malformations to perinatal mortality has almost doubled over the past 10 years and is likely to increase despite prenatal diagnosis and improvements in obstetric and paediatric services.
St John's wort as an antidepressant
Authors: P. A G M De Smet, W. A Nolen
Journal: BMJ (1996)

St John's wort as an antidepressant Longer term studies are needed before it can be recommended in major depression Among the many remarkable differences between German and British medicine is the extensive use of herbal medicines in Germany.An example is the use of Hypericum perforatum (St John's wort) for psychological complaints.In 1994 German physicians prescribed almost 66 million daily doses of preparations containing hypericum alone, worth a total of DM61m (L26m).'In this issue Linde et al (p 253) conclude