tbuckley/cabot-search huggingface dataset:
Inhaled nitric oxide and arterial oxygen tension in patients with chronic obstructive pulmonary disease and severe pulmonary hypertension
Authors: Y. Katayama, T. W. Higenbottam, M. J. Diaz de Atauri, G. Cremona, S. Akamine, J. A. Barbera, R. Rodriguez-Roisin
Journal: Thorax (1997)

BACKGROUND: Inhaled nitric oxide (NO) is a selective pulmonary vasodilator which can improve gas exchange in acute lung injury. However, it is uncertain that this effect on arterial oxygenation can be generalised to all lung diseases. METHODS: The effects of inhaled NO on gas exchange were studied in nine patients with chronic obstructive pulmonary disease (COPD), 11 patients with severe pulmonary hypertension, and 14 healthy volunteers. A randomized sequence of 40 ppm of NO or air was inhaled for 20 minutes through an orofacial mask. RESULTS: Inhaled NO reduced mean (SE) transcutaneous arterial oxygen tension (TcPO2) from 9.6 (0.3) to 8.9 (0.4) kPa in healthy volunteers and from 7.4 (0.6) to 7.0 (0.5) kPa in patients with COPD. There was no change in TcPO2 in patients with severe pulmonary hypertension. During inhalation of NO and air no change occurred in transcutaneous arterial carbon dioxide tension (TcPCO2), arterial oxygen saturation (SaO2) measured by pulse oximeter, or cardiac output determined by the transthoracic impedance method. CONCLUSIONS: Inhaled NO does not improve TcPO2 nor increase cardiac output in normal subjects and patients with COPD, suggesting that inhaled NO worsens gas exchange. This could represent inhaled NO overriding hypoxic pulmonary vasoconstriction in COPD. The finding that TcPO2 also fell when normal subjects inhaled NO suggests that a similar mechanism normally contributes to optimal gas exchange. Whilst inhaled NO can improve oxygenation, this effect should not be considered to be a general response but is dependent on the type of lung disease.
Extending the New York Heart Association Classification System
Authors: William M. Chop
Journal: JAMA (1985)

To the Editor.—  In 1928, the New York Heart Association began using a classification system for heart disease that described a cardiovascular disease state in terms ofetiologic, anatomic, physiologic, andfunctional(nowstatusandprognosis) components. The system has been widely used. Those who use it only superficially often fail to see how it has any advantage over a simple diagnostic name. But, even when it's not used by the book, if it's used thoughtfully, it provides an excellent, concise description of the disease state that goes a long way toward organizing problem lists logically—a description far more useful than a simple diagnostic name. I have found the same scheme to be of great use in describing disease states ofanyorgan system, not just the cardiovascular. (I suppose that others have discovered the same thing, but if so, they haven't spread the news very well; hence, this letter.)
The Risk of Redefining Rationing-Reply
Authors: David C. Hadorn
Journal: JAMA (1992)

<h3>In Reply.</h3> —We believe that necessary-care guidelines could provide a basis for deciding what services should be paid for out of tax dollars or by private insurance plans that choose to provide the benefits we describe in our article. Use of necessary-care guidelines would in no way preclude patients from obtaining services for clinical reasons not covered under those guidelines. Indeed, insurance policies would likely arise to cover such services. However, such policies should not be provided out of pretax dollars (ie, as a nontaxable employee benefit)<sup>1</sup>; individuals wishing to purchase additional services (or insurance to cover those services) should do so without benefit of public subsidy. Finally, we wish to reiterate our belief that a physician- and patient-friendly appeals mechanism should be available to accommodate unusual or atypical clinical presentations that are not covered by the guideline. While we understand Dr Graham's wish that patients and physicians should
Bipolar disorder comorbid with borderline personality disorder and treatment with mood stabilisers
Authors: M. Agius, N. Verdolini
Journal: BMJ (2014)

Crawford and colleagues discuss the difficulty in deciding whether patients with borderline personality disorder (BPD) should be treated with mood stabilisers.1 

This decision is affected by the fact that patients can have two comorbid but distinct conditions—bipolar disorder and BPD. Bipolar disorder has an important genetic component, often with a family history of the disease, whereas BPD is mostly related …
Fatal airway disease in an adult with chronic graft-versus-host disease.
Authors: J Roca, A Granena, R Rodriguez-Roisin, P Alvarez, A Agusti-Vidal, C Rozman
Journal: Thorax (1982)

<h3>Background</h3> Immunoassays remain the primary analytical method for quantification of macromolecules such as monoclonal antibodies (mAbs). For the quantification of mAbs in serum or plasma, study samples are not immediately analysed once collected, and thus the various conditions that study samples undergo must be considered to ensure that analytical stability has not been compromised. <h3>Purpose</h3> To analyse the long term stability of the monoclonal antibody trastuzumab (Herceptin) in serum samples at -20°C. <h3>Material and methods</h3> Blood samples (1.5 mL) were stored in K<sub>2</sub>EDTA tubes (Becton Dickinson, USA). They were immediately sent to the laboratory, centrifuged (2 × 3000 g/5 min) and were divided into two aliquots. One aliquot was immediately analysed. The second aliquot was stored at −20°C for 2 months and then analysed. The immediately analysed samples were considered the baseline value. At the time of analysis, both samples were analysed at dilutions of 1/20 and 1/80 in duplicate to minimise pipetting errors and the intrinsic variation of the method. Serum trastuzumab concentrations were determined by enzyme linked immunosorbent assay (ELISA) using the automated analyser TRITURUS (Grifols). SPSS statistical (v.22.0.0.0) program was used for statistical analysis. Repeated measurements made from the same samples kept under different storage conditions were tested using the Wilcoxon test. A p value &lt;0.05 was considered to be significant. The research protocol was approved by the local ethics committee of our institution. <h3>Results</h3> Blood samples from 4 patients a with diagnosis of HER2+ breast cancer receiving treatment with subcutaneus trastuzumab (Herceptin) were included in the study after providing written informed consent. We did not find a significant difference between the samples analysed immediately and those stored at -20°C for 60 days (p = 0.414) (table 1). <h3>Conclusion</h3> In our study, we observed that serum trastuzumab (Herceptin) samples stored at -20°C were stable for at least 2 months. This was consistent with previous studies. <h3>References and/or Acknowledgements</h3> Ficha Técnica Herceptin No conflict of interest.
Evoecotoxicology: Environmental Changes and Life Features Development duringthe Evolutionary Process—the Record of the Past at DevelopmentalStages of Living Organisms
Authors: Jorge Herkovits
Journal: Environmental Health Perspectives (2006)

For most of evolutionary history, scientific understanding of the environment and life forms is extremely limited. In this commentary I discuss the hypothesis that ontogenetic features of living organisms can be considered biomarkers of coevolution between organisms and physicochemical agents during Earth's history. I provide a new vision of evolution based on correlations between metabolic features and stage-dependent susceptibility of organisms to physicochemical agents with well-known environmental signatures. Thus, developmental features potentially reflect environmental changes during evolution. From this perspective, early multicellular life forms would have flourished in the anoxic Earth more than 2 billion years ago, which is at least 1.2 billion years in advance of available fossil evidence. The remarkable transition to aerobic metabolism in gastrula-stage embryos potentially reflects evolution toward tridermic organisms by 2 billion years ago. Noteworthy changes in embryonic resistance to physicochemical agents at different developmental stages that can be observed in living organisms potentially reflect the influence of environmental stress conditions during different periods of evolutionary history. Evoecotoxicology, as a multidisciplinary and transdisciplinary approach, can enhance our understanding of evolution, including the phylogenetic significance of differences in susceptibility/resistance to physicochemical agents in different organisms.
THE DEVELOPMENT OF PLAY AS A FORM OF THERAPY: FROM ROUSSEAU TO ROGERS
Authors: DELL LEBO
Journal: American Journal of Psychiatry (1955)

Psychoanalysis, while stimulating an interest in diagnosing and treating emotionally disturbed children, soon found its techniques and approaches had to be modified if they were to be used effectively with children. The child could not become an adult in order to be effectively psychoanalyzed. Consequently, the analyst had to go to the child. The importance of play and toys as an analytical tool was recognized. However, it was many years before successful analytic play techniques were established. A variety of active and passive forms of analytical play therapy continue to flourish. Relationship therapy emphasized the present rather than the past, and stressed the importance of the dynamic relationship between the therapist and the patient. As a result, a method of child treatment soon developed from relationship therapy. The postulates of relationship therapy were rapidly absorbed into nondirective therapy. Nondirective beliefs place therapeutic reliance upon the person himself. Nondirective therapy was immediately useable as a form of play therapy. Its original postulates remain unchanged. The development of play in child therapy was an inevitable process, for play therapy, no matter on which therapeutic theory it is based, provides the child with a natural avenue of approach to the therapist. He is enabled to calmly and without embarrassment reveal his ideas, emotions, wishes, attitudes, and fantasies to the therapist. Therapeutic play behavior enables the child to immediately release socially unacceptable impulses and aggressive behavior. He may discharge his feelings without fear of being censured or punished. Such a secure emotional discharge serves to quickly reduce the child's anxiety, enabling him to move safely on to therapeutic experiences.
Clustering of Teenage Suicides after Television News Stories about Suicide
Authors: David P. Phillips, Lundie L. Carstensen
Journal: New England Journal of Medicine (1986)

Abstract We examined the relation between 38 nationally televised news or feature stories about suicide from 1973 to 1979 and the fluctuation of the rate of suicide among American teenagers before and after these stories. The observed number of suicides by teenagers from zero to seven days after these broadcasts (1666) was significantly greater than the number expected (1555; P = 0.008). The more networks that carried a story about suicide, the greater was the increase in suicides thereafter (P = 0.0004). These findings persisted after correction for the effects of the day of the week, the month, holidays, and yearly trends. Teenage suicides increased more than adult suicides after stories about suicide (6.87 vs. 0.45 percent). Suicides increased as much after general-information or feature stories about suicide as after news stories about a particular suicide. Six alternative explanations of these findings were assessed, including the possibility that the results were due to misclassification or were statistical artifacts. We conclude that the best available explanation is that television stories about suicide trigger additional suicides, perhaps because of imitation. (N Engl J Med 1986; 315:685–9.)
For Wallace Stevens
Authors: Eric Pfeiffer
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ALLOGENEIC BONE MARROW TRANSPLANTATION USING STEM CELLS FRACTIONATED BY LECTINS: VI, IN VITRO ANALYSIS OF HUMAN AND MONKEY BONE MARROW CELLS FRACTIONATED BY SHEEP RED BLOOD CELLS AND SOYBEAN AGGLUTININ
Authors: Yair Reisner, RichardJ. O'Reilly, Neena Kapoor, RobertA. Good
Journal: The Lancet (1980)
OPERATIVE TREATMENT OF IRREDUCIBLE DISLOCATIONS OF THE SHOULDER JOINT, RECENT OR OLD, SIMPLE OR COMPLICATED.
Authors: EDMOND SOUCHON
Journal: JAMA (1898)

<h3>25. Irreducibile dislocations, old, spontaneous, or pathologic.</h3> —No case similar to such cases of the coxofemoral articulation has been found on record. 26.<i>Irreducible dislocations, old and paralytic</i>, are irreducible simply because they can not be kept reduced, although they are readily replaced in the socket, because the muscles have lost their power through paralysis of their nervous supyly from peripheral or central causes. The peculiar joint diseases described by Charcot, specially in connection with locomotor ataxia, are also cases in point. The treatment should be directed to the cause. In irreducible old dislocations from paralysis of the deltoid, expose articular surfaces, pare them and let them become anchylosed. The following is a case in point: Julius Wolff, 1886.<sup>108</sup>Irreducible dislocation, old, downward (paralytic), posterior incision, reduction, stitching of head to glenoid cavity, result, improved. Male, aged 5 years.<i>Diagnosis:</i>This was a perpendicular luxation of the shoulder, downward,
Suppressive effect of antibody on processing of T cell epitopes.
Authors: C Watts, A Lanzavecchia
Journal: The Journal of Experimental Medicine (1993)

Immunoglobulins drive efficient antigen capture by antigen presenting cells for processing and presentation on class II MHC-molecules. High affinity antibody/antigen interactions are stable at endosomal/lysosomal pH thus altering the substrate for antigen processing. We show that this can result in strong suppression of presentation of some T cell epitopes. This effect was observed when the antibody specificity was a B cell surface Ig, or formed part of an immune complex. In the latter case the presence of the suppressing antibody boosts presentation of other T cell epitopes through enhanced uptake into Fc receptor bearing cells. The influence of bound antibodies on the outcome of antigen processing may influence with T cell epitopes dominate T cell responses and may change the focus of the response with time.
The Transcription Factor Encyclopedia
Authors: Dimas Yusuf, Stefanie L Butland, Magdalena I Swanson, Eugene Bolotin, Amy Ticoll, Warren A Cheung, Xiao Yu Cindy Zhang, Christopher TD Dickman, Debra L Fulton, Jonathan S Lim, Jake M Schnabl, Oscar HP Ramos, Mireille Vasseur-Cognet, Charles N de Leeuw, Elizabeth M Simpson, Gerhart U Ryffel, Eric W-F Lam, Ralf Kist, Miranda SC Wilson, Raquel Marco-Ferreres, Jan J Brosens, Leonardo L Beccari, Paola Bovolenta, Bérénice A Benayoun, Lara J Monteiro, Helma DC Schwenen, Lars Grontved, Elizabeth Wederell, Susanne Mandrup, Reiner A Veitia, Harini Chakravarthy, Pamela A Hoodless, M Michela Mancarelli, Bruce E Torbett, Alison H Banham, Sekhar P Reddy, Rebecca L Cullum, Michaela Liedtke, Mario P Tschan, Michelle Vaz, Angie Rizzino, Mariastella Zannini, Seth Frietze, Peggy J Farnham, Astrid Eijkelenboom, Philip J Brown, David Laperrière, Dominique Leprince, Tiziana de Cristofaro, Kelly L Prince, Marrit Putker, Luis del Peso, Gieri Camenisch, Roland H Wenger, Michal Mikula, Marieke Rozendaal, Sylvie Mader, Jerzy Ostrowski, Simon J Rhodes, Capucine Van Rechem, Gaylor Boulay, Sam WZ Olechnowicz, Mary B Breslin, Michael S Lan, Kyster K Nanan, Michael Wegner, Juan Hou, Rachel D Mullen, Stephanie C Colvin, Peter John Noy, Carol F Webb, Matthew E Witek, Scott Ferrell, Juliet M Daniel, Jason Park, Scott A Waldman, Daniel J Peet, Michael Taggart, Padma-Sheela Jayaraman, Julien J Karrich, Bianca Blom, Farhad Vesuna, Henriette O'Geen, Yunfu Sun, Richard M Gronostajski, Mark W Woodcroft, Margaret R Hough, Edwin Chen, G Nicholas Europe-Finner, Magdalena Karolczak-Bayatti, Jarrod Bailey, Oliver Hankinson, Venu Raman, David P LeBrun, Shyam Biswal, Christopher J Harvey, Jason P DeBruyne, John B Hogenesch, Robert F Hevner, Christophe Héligon, Xin M Luo, Marissa Cathleen Blank, Kathleen Joyce Millen, David S Sharlin, Douglas Forrest, Karin Dahlman-Wright, Chunyan Zhao, Yuriko Mishima, Satrajit Sinha, Rumela Chakrabarti, Elodie Portales-Casamar, Frances M Sladek, Philip H Bradley, Wyeth W Wasserman
Journal: Genome biology (2012)

Abstract Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium of over 100 researchers has collectively contributed over 130 mini review articles on pertinent human, mouse and rat TFs. Notable features of the TFe website include a high-quality PDF generator and web API for programmatic data retrieval. TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe .
The platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells
Authors: Luciano Cominacini, Anna Fratta Pasini, Ulisse Garbin, Antonio Pastorino, Anna Rigoni, Cristina Nava, Anna Davoli, Vincenzo Lo Cascio, Tatsuya Sawamura
Journal: Journal of the American College of Cardiology (2003)
TCT-779 Acute Severe Mitral Regurgitation Following Balloon Mitral Valvotomy: Echocardiographic Features, Operative Findings, and Outcome in 50 Surgical Cases
Authors: Manjunath Nanjappa, Manjunath Nanjappa, Rajiv Ananthakrishna, Srinivasa Hemanna Setty, Prabhavathi Bhat, Ravindranath Shankarappa, Arunkumar Panneerselvam, Giridhar Kamalapurkar, Seetharama Bhat, Venugopal Ram Rao
Journal: Journal of the American College of Cardiology (2012)
Molecular basis of CD36 deficiency. Evidence that a 478C--&gt;T substitution (proline90--&gt;serine) in CD36 cDNA accounts for CD36 deficiency.
Authors: H Kashiwagi, Y Tomiyama, S Honda, S Kosugi, M Shiraga, N Nagao, S Sekiguchi, Y Kanayama, Y Kurata, Y Matsuzawa
Journal: Journal of Clinical Investigation (1995)

CD36 deficiency is divided into two subgroups: neither platelets nor monocytes express CD36 (type I deficiency), and monocytes express CD36 in spite of the lack of platelet CD36 (type II deficiency). We have already demonstrated that a 478C-->T substitution (proline90-->serine) in platelet CD36 cDNA predominates in type II deficiency (Kashiwagi, H., S. Honda, Y. Tomiyama, H. Mizutani, H. Take, Y. Honda, S. Kosugi, Y. Kanayama, Y. Kurata, and Y. Matsuzawa. 1993. Thromb. Haemostasis. 69:481-484). In this study, we revealed that monocyte CD36 cDNA from two type II deficient subjects was heterozygous for C478 and T478 form, while platelet CD36 cDNA of these subjects consisted of only T478 form. In a type I deficient subject, both platelet and monocyte CD36 cDNA showed only T478 form. Expression assay using C478 or T478 form of CD36 cDNA transfected cells revealed that there was an 81-kD precursor form of CD36, and that the maturation of the 81-kD precursor form to the 88-kD mature form of CD36 was markedly impaired by the substitution. The mutated precursor form of CD36 was subsequently degraded in the cytoplasm. These results indicate that the 478C-->T substitution directly leads to CD36 deficiency via defects in posttranslational modification, and that this substitution is the major defects underlying CD36 deficiency.
FULLY AUTOMATIC DETERMINATION OF LEFT VENTRICULAR VOLUMES AND GLOBAL AND REGIONAL FUNCTION FROM FIRST PASS RADIONUCLIDE VENTRICULOGRMS
Authors: Craig J. Thompson, Ernest V. Garcia, Kenneth A. Narahara, Laurence G. Ranelin, Ismael Mena
Journal: Clinical Nuclear Medicine (1984)

A fully automatic procedure has been developed for determining left ventricular (LV) outlines (including valve planes) from a 16 frame cardiac cycle. The procedure features the following steps: 1) interpolative background subtraction; 2) construction of gradient images; 3) automatic detection of valve planes; 4) radial detection of LV outlines; 5) calculation of LV volumes (V) via area length and of global (G) ejection fraction (EF) and regional (R) EF via the counts method. This procedure allows automatic single study and batch processing. Comparisons of LV V and G EF were assessed in 14 patients undergoing a first pass radionuclide (RN) ventriculogram and a contrast angiogram. The first transit studies were processed from the original list mode data at 2 separate institutions to determine the interobserver/institutional variability caused by the conversion of list modes to frames. Also, studies in 21 patients undergoing sequential first pass ventriculograms with Au-195m were processed to determine the inter-study variability of the method. The results are: Contrast vs RN Inst. 1 vs 2 Study 1 vs 2 LV V R=0.94/SEE=18.7ml R=0.97/SEE=11.8ml R=0.95/SEE=14.9 G EF R=0.84/SEE=6.9 R=0.92/SEE=4.9 R=0.92/SEE=4.8 Finally, from a population of 18 normal patients; normal (mean ± 1 standard deviation) limits of REF have been constructed for 5 cardiac regions. Antero-basal Antero-apical Inferior Posterior Valvular 0.63±0.09 0.72±0.10 0.70±0.09 0.64±0.13 0.54±0.13 This new fully automatic method of quantifying LV V and function vastly reduces operator time and.variability.
The Organization of Health Care
Authors: Kevin Grumbach, Thomas Bodenheimer
Journal: JAMA (1995)

Frank Hope has walked with a limp since his attack of polio in the 1940s. When he watches his daughter run after her young toddler, he experiences a sense of gratitude that the era of vaccinations has protected his child and grandchild from such a disabling infection. He recalls the sense of excitement that gripped the nation as the Salk polio vaccine was first tested and then adopted into widespread use. In Frank's mind, these types of scientific breakthroughs attest to the wonders of the US health care system. Frank's grandson attends a day-care program. Ruby, a 2-year-old girl in his program, was recently hospitalized for a severe case of measles complicated by pneumonia. She spent 2 weeks in a pediatric intensive care unit, including several days on a respirator. She had not received her measles immunization, normally scheduled for 15 months of age. Ruby's mother works full-time as a