tbuckley/cabot-search huggingface dataset:
Effect of In Situ Retroviral Interleukin-4 Transfer on Established Intracranial Tumors
Authors: M. Saleh, A. Wiegmans, Q. Malone, S. S. Stylli, A. H. Kaye
Journal: JNCI Journal of the National Cancer Institute (1999)

BACKGROUND: Current therapies for malignant gliomas remain largely ineffective. We have previously demonstrated that interleukin 4 (IL-4) exhibits antitumorigenic activity in athymic nude mice by promoting both eosinophil infiltration and inhibition of tumor angiogenesis (formation of new blood vessels). In this study, we investigated treatment of established rat C6 cell gliomas by retroviral delivery of IL-4 in situ . METHODS: Tumors grown subcutaneously in athymic nude mice or implanted intracranially in immunocompetent Wistar rats were implanted with ecotropic retrovirus (i.e., will replicate only in cells of closely related species) packaging cells (RPCs) that were transfected with a retroviral vector encoding mouse IL-4 (1C5 cells) or a control vector (SV cells). For the demonstration of the long-term effects of such treatment, C6 cells were also implanted into the contralateral hemisphere of the brains of rats previously treated with 1C5 RPCs. Tumor volume measurements and immunohistochemical analyses were performed. RESULTS: Implantation of 1C5 RPCs into subcutaneous C6 cell tumors resulted in tumor growth arrest that was associated with eosinophil infiltration and inhibition of angiogenesis. When 1C5 RPCs were stereotactically implanted into established intracranial tumors in rats, tumor volumes were dramatically smaller than in control animals (approximately 1.8 mm 3 versus 70-80 mm 3 , respectively) 7 days after treatment. All 1C5 RPC-treated rats survived to 106 days after C6 cell implantation (99 days after treatment; an arbitrary end point), whereas control rats had to be killed 14 days after C6 cell implantation because of extensive tumor growth. Histologic analysis demonstrated that treated tumors were completely eradicated, and immunohistochemical analysis revealed an inhibition of tumor angiogenesis and infiltration by CD8 + cells and macrophages. C6 cells implanted contralaterally into the brains of long-term-surviving rats treated with 1C5 RPCs were also rapidly and completely rejected. CONCLUSIONS: Implantation of packaging cells producing IL-4 retrovirus leads to rapid eradication of rat C6 cell gliomas and provides sustained protection against further intracranial challenge.
Quality Groups Coordinate
Authors: M. J. Friedrich
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 9801: Increased High-Mobility Group Box1 Expression at Ruptured Plaque Was Associated with Microvascular Damage after Reperfusion in Patients with Myocardial Infarction
Authors: Takashi Kohno, Toshihisa Anzai, Takahiro Ohki, Yuji Itabashi, Akihiro Yoshizawa, Tsutomu Yoshikawa, Keiichi Fukuda
Journal: Circulation (2011)

Background: Locally increased inflammatory response at the ruptured plaque contributes to no-reflow phenomenon. High-mobility group box1 (HMGB1) is a potent innate danger signal released from injured and activated immune cells, that initiates pro-inflammatory response. We hypothesized that culprit coronary artery of ST-elevation myocardial infarction (STEMI) contains an elevated level of HMGB1 that may play an adverse role on myocardial reperfusion. Methods and Results: Fifty patients with reperfused STEMI and 35 patients with chronic stable angina (CSA) were examined. Local blood samples from the ruptured plaque were taken in patients with STEMI using aspiration catheterization. Systemic blood samples were taken from the aorta. Local and systemic serum HMGB1 level did not differ between presence or absence of atherosclerotic risk factors, prior use of cardiovascular medications, anterior infarction, collateral, and multivessel disease. Systemic level of HMGB1 was significantly higher in patients with STEMI than in patients with CSA (4.9±2.5 vs. 0.9±1.6 ng/ml, p&lt;0.0001). In patients with STEMI, local serum HMGB1 level at the ruptured plaque was higher compared with systemic level (6.3±4.6 vs. 4.9±2.5 ng/ml, p&lt;0.01). Local HMGB1 level, but not systemic HMGB1 level, was significantly increased in patients with final Thrombolysis In Myocardail Infarction (TIMI) &lt;III (n=7) compared with final TIMI-III (n=43) (9.9±6.3 vs. 5.8±4.1 ng/ml, p&lt;0.05). Among the patients with final TIMI-III, local HMGB1 level was elevated in patients with poor ST-resolution (&lt;50%, n=14) compared with those with good ST-resolution (n=29) (8.2±6.1 vs. 4.8±2.5 ng/ml, p&lt;0.05). Local HMGB1 level was higher in patients with pump failure and ventricular fibrillation/sustained ventricular tachycardia compared with those without (all p&lt;0.05). Conclusions: Serum HMGB1 level was increased not only in the systemic circulation, but also at the site of plaque rupture in patients with STEMI. Elevated HMGB1 level at the ruptured plaque was associated with no-reflow phenomenon, poor ST-resolution, and adverse clinical outcomes, suggesting that HMGB1 might be an important factor contributing to the development of microvascular damage after reperfusion in patients with STEMI.
Streptomycin Treatment of Septicaemia and Meningitis Due to Intestinal Organisms in Infants
Authors: R. Debre, P. Mozziconacci, R. Grumbach, P. Boulard, L. Costil, J. Meyer
Journal: BMJ (1949)

The effectiveness of streptomycin on Gram-negative organisms of the Bact. coli and Salmonella groups in vitro was quickly recognized by Waksman and others, and has led clinicians to make use of this property in the treatment of infection by intestinal organisms.Since 1945 encouraging results of the use of streptomyin have been reported in urinary infections (Helmolz, 1945) and miscellaneous conditions (Herrel and Nichols, 1945).Several authors have confirmed these results (Keefer et al., 1946;Goettsch et al., 1948), and we ourselves, struck with the frequency of septicaemia and meningitis of this type in the newborn and the infant, have reported our preliminary investigations (Debre, Mozziconacci, Grumbach, and Boulard, 1948).We were able to collect 41 cases of infection due to organisms of the Salmonella groups and of the Bact. coli and similar groups-infection which previously was fatal but in which streptomycin has given appreciable results.We think, however, that our technique might be improved and we hope for still better results in the future.
Technical Zeal or Therapeutic Purpose— How to Decide?
Authors: Ralph Crawshaw
Journal: JAMA (1983)

A practicing psychiatrist recounts the harrowing experience of a colleague in attempting to persuade his brother's physician to cease useless therapeutic efforts. Crawshaw argues that biomedical technologies encourage medical zealotry and suggests that machines dictate treatment, interfering with appropriate decision making by physicians and patients. He urges hospitals to provide appeals mechanisms for patients, families, and physicians.
Improved Retinal Function in a Mouse Model of Dominant Retinitis Pigmentosa Following AAV-delivered Gene Therapy
Authors: Naomi Chadderton, Sophia Millington-Ward, Arpad Palfi, Mary O'Reilly, Gearóid Tuohy, Marian M Humphries, Tiansen Li, Peter Humphries, Paul F Kenna, G Jane Farrar
Journal: Molecular Therapy (2009)

Mutational heterogeneity represents one of the greatest barriers impeding the progress toward the clinic of gene therapies for many dominantly inherited disorders. A general strategy of gene suppression in conjunction with replacement has been proposed to overcome this mutational heterogeneity. In the current study, various aspects of this strategy are explored for a dominant form of the retinal degeneration, retinitis pigmentosa (RP), caused by mutations in the rhodopsin gene (RHO-adRP). While > 200 mutations have been identified in rhodopsin (RHO), in principle, suppression and replacement may be employed to provide a single mutation-independent therapeutic for this form of the disorder. In the study we demonstrate in a transgenic mouse simulating human RHO-adRP that RNA interference-based suppression, together with gene replacement utilizing the endogenous mouse gene as the replacement, provides significant benefit as evaluated by electroretinography (ERG). Moreover, this is mirrored histologically by preservation of photoreceptors. AAV-based vectors were utilized for in vivo delivery of the therapy to the target cell type, the photoreceptors. The results demonstrate that RNAi-based mutation-independent suppression and replacement can provide benefit for RHO-adRP and promote the therapeutic approach as potentially beneficial for other autosomal dominantly inherited disorders.
Photodynamic therapy using chlorophyll-a in the treatment of acne vulgaris: A randomized, single-blind, split-face study
Authors: Byong Han Song, Dong Hun Lee, Byung Chul Kim, Sang Hyeon Ku, Eun Joo Park, In Ho Kwon, Kwang Ho Kim, Kwang Joong Kim
Journal: Journal of the American Academy of Dermatology (2014)
Treatment of Panic Attack and Risk of Major Depressive Disorder in the Community
Authors: Renée Goodwin, Mark Olfson
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: The authors' goal was to determine whether treatment of panic attacks has a protective effect on the risk of major depression in the community. METHOD: Data were drawn from the National Comorbidity Survey, a community-based household sample representative of the U.S. adult population. A Cox proportional hazard model was used to estimate the association between risk of first-onset major depression and panic among subjects who had or had not received treatment for panic. RESULTS: A significantly smaller proportion of individuals who received treatment for panic (19%) than those who did not receive treatment (45%) developed major depression. This difference remained significant in a Cox proportional hazard analysis adjusted for age at onset of panic and differences in demographic characteristics. CONCLUSIONS: Detection and treatment of panic may reduce the risk of developing major depression.
The Hills of Sidon: Journal From South Lebanon 1983-85
Authors: John C. Rose
Journal: JAMA (1989)

While world estimates vary hugely, some assert that there are over 40 million refugees and displaced persons. This has been called the greatest human problem of these last decades of the century. For many young people with a desire to serve—college students, medical students, house staff, nurses, and others—this is a population of which they should be very much aware, one that needs their services. Leila Richards, MD, has written an exciting and often moving account of a nearly two-year experience among Palestinians and Lebanese in South Lebanon, largely refugees and displaced persons. This patient, brave, determined, and compassionate physician tells of the ordeal of setting up, staffing, and operating a small hospital financed by the International Rescue Committee with funds from the US State Department. The hospital is located on the outskirts of Ein-el-Hilweh, a large Palestinian refugee camp near the port city of Sidon. This is a human
Systemic blood pressure elevation after airway occlusion during NREM sleep.
Authors: J Ringler, E Garpestad, R C Basner, J W Weiss
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Increases in arterial pressure follow obstructive sleep apneas even in the absence of hypoxemia. These blood pressure (BP) elevations could be caused by arousal from sleep, resumption of ventilation, or abrupt changes of intrathoracic pressure (ITP). To better define the relative contributions of each of these factors to the BP elevations, we designed two protocols employing six normal subjects isolating the effects of arousal from those of ventilation and ITP. BP (Penaz method), sleep stage, air flow, and esophageal pressure (Pes) were monitored. Episodically, a stopcock was closed, occluding the inspiratory circuit. In Experiment 1, data were recorded on tape. Occlusions were initiated during Stage 2 NREM sleep and released coincident with arousal. Subjects were than awakened and instructed to trace the displayed, taped Pes profile creating occlusions of identical duration to those recorded during sleep. In five subjects, the mean BP elevation (preocclusion to peak) associated with occlusion release upon arousal was 19.0 +/- 5.1 mm Hg, whereas the analogous rise for matched awake occlusions was 5.4 +/- 4.8 mm Hg (p = 0.027). In Experiment 2, occlusion release was delayed 6 to 12 s after arousal. In five subjects, these occlusions were associated with BP elevations that peaked coincident with arousal, not with resumption of ventilation (mean increase, 18.0 +/- 10.4 mm Hg). We conclude that under the conditions of these experiments, BP elevations after airway occlusion during sleep are attributable more to arousal than to resumption of ventilation.
ABDOMINAL PAIN AND PNEUMONIA.
Authors: G. H. SCOTT
Journal: JAMA (1904)

In connection with the instructive paper by Dr. Herrick inThe Journalof the American Medical Association on "Abdominal Pain in Pleurisy and Pneumonia," I report the following case: The patient, a native female, single, aged 20, of previous good health, suddenly was seized about 10 a. m. with a violent chill, followed by very severe pain in the umbilical region. This lasted for about an hour. About 5 p. m. the pain returned, and she had a sensation of "burning up," as she expressed it. I saw the patient for the first time about 9 p. m. The abdominal pain seemed to radiate downward and laterally from the umbilicus, but did not extend above that point. It was of a dull, aching character, although the first paroxysm had been of a sharp, stabbing nature. No evidence of tenderness was found, and there was no rigidity or tympany. Bowel
PET/CT Imaging of Conus Medullaris Metastasis From Lung Cancer
Authors: Ba D. Nguyen, Geoffrey P. Fletcher, Ameet C. Patel
Journal: Clinical Nuclear Medicine (2005)

An intradural extramedullary metastasis is usually detected at an advanced stage of the disease or during workup for manifestations of spinal cord compression. Early diagnosis of such a lesion is rare and mostly fortuitous. The authors present a case of treated nonsmall cell lung carcinoma with an asymptomatic conus medullaris metastasis, which was demonstrated by PET/CT imaging during restaging evaluation.
Human Fetal Testis Xenografts Are Resistant to Phthalate-Induced Endocrine Disruption
Authors: Nicholas E Heger, Susan J Hall, Moses A Sandrof, Elizabeth V McDonnell, Janan B Hensley, Erin N McDowell, Kayla A Martin, Kevin W Gaido, Kamin J Johnson, Kim Boekelheide
Journal: Environmental Health Perspectives (2012)

In utero exposure to endocrine-disrupting chemicals may contribute to testicular dysgenesis syndrome (TDS), a proposed constellation of increasingly common male reproductive tract abnormalities (including hypospadias, cryptorchidism, hypospermatogenesis, and testicular cancer). Male rats exposed in utero to certain phthalate plasticizers exhibit multinucleated germ cell (MNG) induction and suppressed steroidogenic gene expression and testosterone production in the fetal testis, causing TDS-consistent effects of hypospadias and cryptorchidism. Mice exposed to phthalates in utero exhibit MNG induction only. This disparity in response demonstrates a species-specific sensitivity to phthalate-induced suppression of fetal Leydig cell steroidogenesis. Importantly, ex vivo phthalate exposure of the fetal testis does not recapitulate the species-specific endocrine disruption, demonstrating the need for a new bioassay to assess the human response to phthalates. In this study, we aimed to develop and validate a rat and mouse testis xenograft bioassay of phthalate exposure and examine the human fetal testis response. Fetal rat, mouse, and human testes were xenografted into immunodeficient rodent hosts, and hosts were gavaged with a range of phthalate doses over multiple days. Xenografts were harvested and assessed for histopathology and steroidogenic end points. Consistent with the in utero response, phthalate exposure induced MNG formation in rat and mouse xenografts, but only rats exhibited suppressed steroidogenesis. Across a range of doses, human fetal testis xenografts exhibited MNG induction but were resistant to suppression of steroidogenic gene expression. Phthalate exposure of grafted human fetal testis altered fetal germ cells but did not reduce expression of genes that regulate fetal testosterone biosynthesis.
Novak's Gynecology
Authors: Larry McGowan
Journal: JAMA (1997)

Gynecology An old friend has returned after a hiatus of 8 years:<i>Novak's Gynecology</i>, now in its 12th iteration. The editors and 45 contributors offer a nationwide perspective on the practice of gynecology. The textbook has been completely revised and reorganized, but the editors state that its essence is the same—a comprehensive general textbook of gynecology. The distinctive page design, with marginal topic headings, rules, and boldface type, allows for easier reading and access to specific information or topics the reader may need. References are certainly more easily used in this new format. <i>Novak's Gynecology</i>has six sections, beginning with "Principles of Practice" and "Basic Sciences." In the new section, "Preventive and Primary Care," the authors quite properly stress the importance of primary health care for women, which has evolved to include preventive care, screening, family planning, sexuality, and common psychiatric problems. The remaining sections are "General Gynecology," "Reproductive Endocrinology,"
Volumeric analysis of in-stent intimal hyperplasia in diabetic patients treated with or without abciximab: Results of the DANTE randomized trial
Authors: Aurea J. Chaves, Luiz Mattos, Alexandre A. Abizaid, Rodolfo Staico, Fausto Feres, Marinella Centemero, Luiz F. Tanajura, Andrea S. Abizaid, Ana Seixas, Ibraim Pinto, Marco Costa, Arilson Rodrigues, Angela Paes, Amanda Sousa, Jose Eduardo M. Sousa
Journal: Journal of the American College of Cardiology (2003)
Persistence of Individual Variations in Glycated Hemoglobin
Authors: Darrell M. Wilson, Dongyuan Xing, Jing Cheng, Roy W. Beck, Irl Hirsch, Craig Kollman, Lori Laffel, Jean M. Lawrence, Nelly Mauras, Katrina J. Ruedy, Eva Tsalikian, Howard Wolpert
Journal: Diabetes Care (2011)

To determine the individual persistence of the relationship between mean sensor glucose (MG) concentrations and hemoglobin A(1c) (A1C) from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring (CGM) Randomized Trial.MG was calculated using CGM data for 3 months before A1C measurements at 3, 6, 9, and 12 months for the CGM group and at 9 and 12 months for the control group. An MG-to-A1C ratio was included in analysis for subjects who averaged ≥4 days/week of CGM use.Spearman correlations of the MG-to-A1C ratio between consecutive visits 3 months apart ranged from 0.70 to 0.79. The correlations for children and youth were slightly smaller than those for adults. No meaningful differences were observed by device type or change in A1C.Individual variations in the rate of hemoglobin glycation are persistent and contribute to the inaccuracy in estimating MGs calculated from A1C levels.
The Developing Concept of the Therapeutic Community
Authors: D.H. Clark
Journal: Psychotherapy and Psychosomatics (1965)

Research Articles| February 11 2010 The Developing Concept of the Therapeutic Community Subject Area: Psychiatry and Psychology D.H. Clark D.H. Clark Fulbourn Hospital, Cambridge Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1965) 13 (1-3): 238–245. https://doi.org/10.1159/000285772 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation D.H. Clark; The Developing Concept of the Therapeutic Community. Psychother Psychosom 31 December 1965; 13 (1-3): 238–245. https://doi.org/10.1159/000285772 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1965Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Health promotion in general practice: Evidence of benefit
Authors: J Hawker, N Dhillon, M Conroy, A McConville, R Holder, A Jones
Journal: BMJ (1993)

be fully funded and must therefore address only the most limited and primitive expectations of both the patients and the professionals.The persistent clinical poverty of most NHS general practice cannot be cured or palliated by bolting on such token luxuries as well person clinics.Unless the BMA finds the courage and imagination to insist on resources for a labour intensive rather than a technology intensive public service, aiming at comprehensive anticipatory care for our whole population, even the best practices will continue to report failure.