tbuckley/cabot-search huggingface dataset:
Minimizing the Inhibitory Effect of Neutralizing Antibody for Efficient Gene Expression in the Liver With Adeno-associated Virus 8 Vectors
Authors: Jun Mimuro, Hiroaki Mizukami, Shuji Hishikawa, Tomokazu Ikemoto, Akira Ishiwata, Asuka Sakata, Tsukasa Ohmori, Seiji Madoiwa, Fumiko Ono, Keiya Ozawa, Yoichi Sakata
Journal: Molecular Therapy (2012)

Neutralizing antibodies (NAbs) against adeno-associated viruses (AAVs) are known to interfere with AAV vector-mediated gene transfer by intravascular delivery. Evading the inhibitory effects of antibodies against AAV vectors is necessary for efficient transfer of therapeutic genes clinically. For this purpose, we tested the efficacy of saline flushing in order to avoid contact of vectors with NAbs present in blood. Direct injection of the AAV8 vector carrying the factor IX (FIX) gene into the portal vein of macaques using saline flushing achieved transgene-derived FIX expression (4.7 ± 2.10-10.1 ± 5.45% of normal human FIX concentration) in the presence of NAbs. Expression was as efficient as that (5.43 ± 2.59-12.68 ± 4.83%) in macaques lacking NAbs. We next tested the efficacy of saline flushing using less invasive balloon catheter-guided injection. This approach also resulted in efficient expression of transgene-derived FIX (2.5 ± 1.06-9.0 ± 2.37%) in the presence of NAbs (14-56× dilutions). NAbs at this range of titers reduced the efficiency of transduction in the macaque liver by 100-fold when the same vector was injected into mesenteric veins without balloon catheters. Our results suggest that portal vein-directed vector delivery strategies with flushing to remove blood are efficacious for minimizing the inhibitory effect of anti-AAV antibodies.
"AN EXPEDIENT TO CONTROL EPISTAXIS"
Authors: J. B. H. Waring
Journal: JAMA (1924)

<h3>To the Editor:</h3> —With reference to the note on this subject inThe Journal, January 19, it will be found easier and far more effective than gauze packing simply to place two or more Bernay's sponge splints inside the previously lubricated finger cot, which is then introduced with nasal dressing forceps, or with the fingers if forceps are not at hand, into the nasal orifice from which comes the hemorrhage. A drop or two of hydrogen peroxid or sterile water on the ends of the splints causes them to expand rapidly, filling the nasal passage with a firm, even pressure, which will not only quickly stop bleeding in Kiesselbach's area, but farther back and upward, if needed. While, no doubt, this maneuver is known to many rhinologists, it is at once so neat and simple in its effectiveness that every physician should know of it. It is needless to say
Hemodynamic Effects of Chronic Prenatal Ventricular Pacing for the Treatment of Complete Atrioventricular Block
Authors: John R. Liddicoat, Judith R. Klein, V. Mohan Reddy, Robert J. M. Klautz, David F. Teitel, Frank L. Hanley
Journal: Circulation (1997)

Background Increasing the heart rate of the fetus with cardiac failure caused by complete AV block (CAVB) may allow delivery of a full-term, stable neonate with preserved ventricular function. Direct fetal pacing may be a feasible method to achieve this, but the effect of pacing on the structure and function of the rapidly developing fetal heart is unknown. Methods and Results CAVB was created in fetal lambs at 80% gestation by cryoablating the AV node. Epicardial ventricular pacing at 130 bpm was achieved by use of a pacemaker placed under the pectoral muscles. The fetus was returned to the uterus and allowed to continue to term. Ventricular function was assessed 1 week after birth in 7 lambs with CAVB and 10 control lambs. By use of the conductance catheter technique, the end-systolic pressure-volume relationship was determined at different heart rates, pacing conditions, and inotropic states. The contractility was not different between the two groups at their baseline heart rates and rhythms or when they were paced synchronously compared with asynchronously. Also, both groups responded significantly and similarly to inotropic manipulation, indicating preserved contractile reserve. Finally, in both groups, increased heart rates were associated with increased contractility, indicating an intact force-frequency relationship. Conclusions We conclude that chronic epicardial ventricular pacing is well tolerated by the fetus, can be successfully applied as a treatment for CAVB, and does not adversely affect myocardial function in the rapidly developing, immature heart.
FALLING DROP TECHNICS
Authors: B. M. Kagan
Journal: JAMA (1942)

<h3>To the Editor:—</h3> InThe Journal, January 17, page 248, there appears a communication from H. G. Barbour and S. F. Hamilton criticizing falling drop technic other than the one which they developed. My calculations and procedure (<i>J. Clin. Investigation</i><b>17</b>: 369, 373 [July] 1938;<i>J. Lab. &amp; Clin. Med.</i><b>26</b>:1681 [July] 1941) were based on Stokes's law for the fall of a sphere through a viscous medium, which was proved in 1851; though no author until I myself applied Stokes's great contribution, many contributed to the evolution of this determination. The application of Stokes's law eliminated Barbour and Hamilton's "vagaries" of oils "under different conditions of temperature." It also greatly simplified the calculations and eliminated the complex logarithmic expression and the admittedly unsatisfactory nomogram required in their technic. Barbour and Hamilton themselves point out (<i>J. Biol. Chem.</i><b>69</b>: 639 [Aug.] 1926) that expansion and contraction of the paper
National Practice Patterns for Management of Adult Congenital Heart Disease
Authors: Tara Karamlou, Brian S. Diggs, Thomas Person, Ross M. Ungerleider, Karl F. Welke
Journal: Circulation (2008)

Surgery for grown-up (age > or = 18 years) patients with congenital heart disease (GUCH) is frequently performed by surgeons without specialization in pediatric heart surgery. We sought to define national practice patterns and to determine whether outcomes for GUCH patients are improved if they are treated by specialized pediatric heart surgeons (PHSs) compared with non-PHSs.We identified index cardiac procedures in patients with 12 congenital heart disease diagnostic groups using the Nationwide Inpatient Sample 1988 to 2003. PHSs were defined as surgeons whose annual practice volumes were made of >75% annual pediatric heart cases. GUCH operations were defined as operations within these 12 diagnoses occurring in patients > or =18 years of age. We identified 30,250 operations, yielding a national estimate of 152,277 +/- 7,875 operations. Of these, 111,816 +/- 7,456 (73%) were pediatric operations, and 40,461 +/- 1,365 (27%) were GUCH operations. PHSs performed 68% of pediatric operations in all diagnostic groups, whereas non-PHSs performed 95% of GUCH operations within the same diagnostic groups (P<0.0001). In-hospital death rates for GUCH patients operated on by PHSs were lower than death rates for GUCH patients operated on by non-PHSs (1.87% [95% CI, 0.62 to 3.13] versus 4.84% [95% CI, 4.30 to 5.38%]; P<0.0001). Survival advantage increased with increasing surgeon annual pediatric volume (P=0.0031).Pediatric patients within specific diagnostic groups are more likely to undergo operation by PHSs, whereas GUCH patients within the same diagnostic groups are more likely to undergo operation by non-PHSs. In-hospital death rates are lower for GUCH patients operated on by PHSs. GUCH patients should be encouraged to obtain surgical operation by PHS.
Laser microdissection and mass spectrometry–based proteomics aids the diagnosis and typing of renal amyloidosis
Authors: Sanjeev Sethi, Julie A. Vrana, Jason D. Theis, Nelson Leung, Anjali Sethi, Samih H. Nasr, Fernando C. Fervenza, Lynn D. Cornell, Mary E. Fidler, Ahmet Dogan
Journal: Kidney International (2012)

Accurate diagnosis and typing of renal amyloidosis is critical for prognosis, genetic counseling, and treatment. Laser microdissection and mass spectrometry are emerging techniques for the analysis and diagnosis of many renal diseases. Here we present the results of laser microdissection and mass spectrometry performed on 127 cases of renal amyloidosis during 2008-2010. We found the following proteins in the amyloid deposits: immunoglobulin light and heavy chains, secondary reactive serum amyloid A protein, leukocyte cell-derived chemotaxin-2, fibrinogen-α chain, transthyretin, apolipoprotein A-I and A-IV, gelsolin, and β-2 microglobulin. Thus, laser microdissection of affected areas within the kidney followed by mass spectrometry provides a direct test of the composition of the deposit and forms a useful ancillary technique for the accurate diagnosis and typing of renal amyloidosis in a single procedure.
Extracorporeal Piezoelectric Lithotripsy for Retained Bile Duct Stones
Authors: J. Weber, H. E. Adamek, J. F. Riemann
Journal: Endoscopy (1992)

Extracorporeal piezoelectric shock wave lithotripsy (EPL) was performed in 35 patients with endoscopically non-extractable stones. With this lithotripter, stones are visualized by ultrasound and shock waves are produced by a piezoelectric acoustic generator. The stones could be localized in 32 out of 35 patients. Fragmentation was achieved in 91.4 % and complete stone removal in 77.1 %. These results show that piezoelectric lithotripsy is also a useful method for the treatment of complicated bile duct stones, as already demonstrated for the electrohydraulically and electromagnetically generated shock waves systems. The piezoelectric system is especially useful in elderly and frail patients because no general anesthesia is needed and only 14 % of cases require analgesia or sedation.
The Department of Veterans Affairs Smoke-Free Policy
Authors: Anne M. Joseph, Patricia J. O'Neil
Journal: JAMA (1992)

THE Department of Veterans Affairs (VA), the largest health care provider in the United States, implemented an agency policy on January 7, 1991, requiring all 172 acute-care hospitals to be completely smoke-free.<sup>1-3</sup>The VA initiative followed directives by other government agencies for smoke-free environments, such as the US Army<sup>4</sup>and the Indian Health Service.<sup>5</sup>Smoke-free hospitals have been endorsed by the American Medical Association, the American College of Physicians, and the US Preventive Services Task Force, as well as other organizations.<sup>6</sup> This policy was written in a national climate that is increasingly intolerant of environmental tobacco smoke, although hospitals commonly continue to allow smoking in designated areas. Several medical centers have become completely smoke-free,<sup>7-13</sup>and the states of Minnesota and Maine have passed legislation requiring health care institutions to be smoke-free. Because of the national trend in legislation of public smoking (including the Joint Commission
Anorexia Nervosa
Authors: R. M. Boyar, J. Katz, J.W. Finkelstein, S. Kapen, H. Weiner, E.D. Weitzman, Leon Hellman
Journal: New England Journal of Medicine (1974)

Nine women (17 to 23 years of age) with primary anorexia nervosa associated with amenorrhea had measurements of plasma luteinizing hormone concentrations at 20-minute intervals for 24 hours. Eight of the nine showed age-inappropriate secretory patterns that resembled those found in prepubertal and pubertal children. The finding of an "immature" luteinizing hormone pattern suggests that a "regression" (in the patients with secondary amenorrhea) or an "arrest" (in the patients with primary amenorrhea) of the luteinizing hormone secretory "program" occurs in this disorder. One patient had a spontaneous remission, with return of body weight to normal, associated with a maturational change from the early pubertal luteinizing hormone pattern found during her illness to one characteristic of postmenarchal girls, indicating the reversibility of this abnormality. The finding of a relation between body weight and the maturity of the luteinizing hormone pattern supports the hypothesis that a "critical body weight" is an important factor in the initiation of menarche. (N Engl J Med 291: 861 -865, 1974)
Early treatment strategies in sepsis
Authors: Mohammed A Butt, A K Coulson, J H Hull, T B L Ho
Journal: BMJ (2008)

Minton et al add to a gathering body of evidence that poor clinical practice in the initial management of patients with bloodstream infections contributes to increased morbidity and mortality.1

We recently performed a retrospective study of 35 patients with community acquired pneumonia and septicaemia transferred within 48 hours of admission to a district general intensive care unit …
Nutrition in Child Health
Authors: A. Ashworth
Journal: BMJ (1996)

Ed D P Davies Royal College of Physicians, pounds sterling19.50, pp 240 ISBN 1 86016 018 2

I cannot recall a more exciting time in the study of paediatric nutrition. This excitement, excellently conveyed in Nutrition in Child Health, has several components, but perhaps foremost is the element of surprise.

Consider for example, the sense of astonishment that engulfed the nutrition and medical fraternity at David Barker's theory that our destiny—in terms of hypertension, stroke, coronary heart disease, and noninsulin dependent diabetes—results not primarily from external factors such as lifestyle but from the body's self …
Richard H. L. Bohannon, MD
Authors: Phil Gunby
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accuracy and value of the Haemoccult test
Authors: R. J Leicester, D. G Colin-Jones, R. H Hunt
Journal: BMJ (1983)

the diagnoses of only 76 out of the 140 patients with a positive Haemoccult test result, however, these being a colorectal neoplasm, diverticulitis, Crohn's disease, and angiodysplasia.What were the diagnoses in the other 64 patients ?What were the diagnoses and their incidences in the original 802 patients (for comparison) ?What proportion of the latter had no detectable disease ?Incidentally, what were the original presenting symptoms which defined the patients being studied ?
George Washington and Smallpox
Authors: Benjamin A. Drew
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
The Role of Angiography in Cardiogenic Shock
Authors: ROBERT C. LEINBACH, HERMAN K. GOLD, ROBERT E. DINSMORE, ELDRED D. MUNDTH, MORTIMER J. BUCKLEY, W. GERALD AUSTEN, CHARLES A. SANDERS
Journal: Circulation (1973)

Eighty patients with cardiogenic shock secondary to myocardial infarction were treated with the intra-aortic balloon pump (IABP). The initial response to pumping was good, with resolution of shock in 80%. Sixty-eight patients did not tolerate subsequent withdrawal from IABP and were termed balloon-dependent. Selective coronary and left ventricular cineangiography in 52 balloon-dependent patients identified 30 possible surgical candidates. Operative procedures in 24 produced 9 survivors (37%). Persistent dependence upon mechanical circulatory assistance after myocardial infarction may not indicate massive ventricular infarction. Early angiography after initial hemodynamic improvement on IABP is an essential step in the identification of those patients with persistent, reversible ischemia in whom emergency surgery may be indicated.
Poetry and Medicine
Authors: Barri Armitage
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spray adhesives and birth defects
Authors: J. W. Hanson
Journal: JAMA (1976)

To the Editor.—  In August 1973, spray adhesives were removed from the market in the United States because of concern that they might be mutagenic or cause birth defects or both. 1 With the cooperation of several geneticists and public health persons, we registered 41 families that had sought reproductive counseling because of a current pregnancy and because of exposure to spray adhesives prior to conception or during the first trimester or both.  Of these 41 families, three were lost to follow-up, and there was no pregnancy in two families. From the remaining 36 pregnancies, 33 infants were born without birth defects, two infants were born with birth defects, and one fetus was aborted spontaneously. One of the infants with birth defects had a clubfoot, and the other died in the neonatal period from congenital heart disease. The outcome of this small cohort of pregnancies suggests no unusual occurrence of
A Necessary Correction.
Authors: G. A. Baxter
Journal: JAMA (1892)

Southern Surgical and Gynecological Transactions, Vol. IV, page 163.—"Dr. George A. Baxter, Chattanooga, Tenn.: I declare myself positively in favor of early operation in these cases, but I want to relate a case such as will be, and is used against it. A gun specially loaded for the object was discharged at a distance of less than twenty feet, and one negro had shot another in the back, seventeen balls by actual count entering the right kidney. One of them was detected underneath the skin, further around to the right side; and one, evidently striking some portion of the spinal column, was detected in the clothes. Fifteen balls, however, could not be found by those gentlemen first having the case in charge. The man came under my care six days after the injury, with no indication of peritonitis; but he had at that time an enormously enlarged liver and stomach.
An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: Assessment of efficacy and safety in 2813 patients
Authors: Diane Thiboutot, Andrea Zaenglein, Jonathan Weiss, Guy Webster, Barry Calvarese, Diana Chen
Journal: Journal of the American Academy of Dermatology (2008)
Transforming Clinical Trials in Cardiovascular Disease
Authors: Elliott M. Antman, Robert A. Harrington
Journal: JAMA (2012)

A S EMPHASIZED BY THE BIPARTISAN POLICY CENTER, healthcareexpendituresareanticipatedtoreach20% of US gross domestic product by 2020 and are a major threat to the sustainability of the health care system and to the economic productivity and stability of the country.Althoughdeathratesattributabletocardiovasculardisease(CVD)havedeclinedbyalmostone-thirdover the last11⁄2 decades, CVD remains the leading cause of death and the burden of CVD remains unacceptably high, especially considering the aging of the population. The economic effects of the burden of CVD are profound because managing CVD constitutes 16% of overall national health care expenditures. Given thesesoberingstatistics, it is “missioncritical” toexaminehow progress has been made in addressing CVD and to determine what steps need to be taken to further improve individual and societal cardiovascular health and economic well-being. This is a highly relevant week for such reflection, given the current themeissueof JAMAonCVDandtheoccurrenceof the 2012 Annual Scientific Sessions of the American Heart Association(AHA),whereattendeesfromaroundtheglobewillgather in Los Angeles to discuss the latest findings in cardiovascular science.Thismeetingwill includemore than4400original abstracts, 376 invited scientific sessions, and the first public presentation of 27 late-breaking clinical trials. The National Center for Advancing Translational Sciences (NCATS) is dedicated to catalyzing innovative methods and technologies to enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range ofhumandiseasesandconditions.Randomizedcontrolledtrials (RCTs)areacornerstoneofmodernclinical scienceandacritical tool for theclinical/translational investigator toevaluate the benefits and risks of promising scientific advances.