tbuckley/cabot-search huggingface dataset:
Cyclic Laryngeal Edema with Aphonia
Authors: LUBOMIR J. VALENTA
Journal: Annals of Internal Medicine (1975)

Letters1 January 1975Cyclic Laryngeal Edema with AphoniaLUBOMIR J. VALENTA, M.D.LUBOMIR J. VALENTA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-1-62 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn July 1974 we saw Mrs. B. for the first time. This 24-year-old woman complained of aphonia of 5 to 7 days' duration, which was followed by several days of hoarseness. Such episodes had occurred with each of her menstrual periods through the previous 8 months.Her menarche had been at age 14, and her menses were regular ever since. Five years ago she became pregnant, but miscarried in the third month of pregnancy. She never became pregnant again. A year ago a diagnosis of left-sided ovarian cyst was made and the cyst was removed surgically. The pelvic organs were...References1. COLEMANHORWITHBROWN MMJ: Idiopathic edema. Studies demonstrating protein leaking angiopathy. Am J Med 49:106-112, 1970 CrossrefMedlineGoogle Scholar2. ROVNER D: The enigma of idiopathic cyclic edema. Hosp Tract 7:103-110, 1972 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LUBOMIR J. VALENTA, M.D.Affiliations: Department of Medicine, College of Human Medicine B220 Life Sciences I Michigan State University East Lansing, Michigan 48824 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVariability of fundamental frequency measuresThe effects of premenstrual syndrome (PMS) on the female singerPseudoasthma: A new clinical entity? 1 January 1975Volume 82, Issue 1Page: 62-63KeywordsEdemaMenarchePregnancy ePublished: 1 December 2008 Issue Published: 1 January 1975 PDF downloadLoading ...
Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.
Authors: P G Gallagher, S A Weed, W T Tse, L Benoit, J S Morrow, S L Marchesi, N Mohandas, B G Forget
Journal: Journal of Clinical Investigation (1995)

We studied a kindred in which four third-trimester fetal losses occurred, associated with severe Coombs-negative he- molytic anemia and hydrops fetalis.Postmortem examination of two infants revealed extensive extramedullary erythropoiesis.Studies of erythrocytes and erythrocyte mem- branes from the parents revealed abnormal erythrocyte membrane mechanical stability as well as structural and functional abnormalities in spectrin, the principal structural protein of the erythrocyte membrane.Genetic studies identi- fied a point mutation of the p-spectrin gene, S2019P, in a region of ,B spectrin that is critical for normal spectrin func- tion.Both parents and two living children were heterozy- gous for this mutation; three infants dying of hydrops fetalis were homozygous for this mutation.In an in vitro assay using recombinant peptides, the mutant 8-spectrin peptide demonstrated a significant abnormality in its ability to inter- act with a spectrin.This is the first description of a molecu- lar defect of the erythrocyte membrane associated with hy- drops fetalis.(
Health Manpower Development and Rural Services
Authors: Douglas A. Fenderson
Journal: JAMA (1973)

Last year at the 25th National Conference in San Francisco, Dr. Merlin K. DuVal, then Assistant Secretary for Health and Scientific Affairs, concluded his report by saying that "solutions to rural health problems can be found. In turn, government will do its part."<sup>1</sup> Recent federal priority and budget shifts, however, suggest a prior question and answer. Government—who? The government is you. You recall the oft-quoted statement in Kennedy's 1961 Inaugural Address: "Ask not what your country can do for you; ask what you can do for your country." Our country is vast: it was not clear to many just how that noble purpose could be put into practice. The new federalism makes the idea much clearer—"Ask not what your country can do for you; ask rather what you can do for yourself." Laws are not intrinsically good; they represent the breakdown of community and social process and indicate the
Timosaponin A-III Induces Autophagy Preceding Mitochondria-Mediated Apoptosis in HeLa Cancer Cells
Authors: Lai-King Sy, Siu-Cheong Yan, Chun-Nam Lok, Ricky Y.K. Man, Chi-Ming Che
Journal: Cancer Research (2008)

Abstract Timosaponin A-III (TAIII), a saponin isolated from the rhizome of Anemarrhena asphodeloides, exhibits potent cytotoxicity and has the potential to be developed as an anticancer agent. Here, we provide evidence that TAIII induces autophagy in HeLa cells followed by apoptotic cell death. TAIII-induced autophagy was morphologically characterized by the formation of membrane-bound autophagic vacuoles recognizable at the ultrastructural level. TAIII-treated cells expressing green fluorescent protein (GFP)–labeled microtubule-associated protein 1 light chain 3 (LC3) displayed punctate fluorescence indicative of LC3 recruitment to the autophagosome. This was associated with the conversion of LC3-I (the cytosolic form) into LC3-II (the lipidated form located on the autophagosome membrane). TAIII treatment also induced mitochondrial dysfunction involving overproduction of reactive oxygen species and reduction of mitochondrial membrane potential accompanied by induction of mitochondrial permeability transition. Prolonged exposure to TAIII resulted in cytochrome c release and caspase-3 activation, events that signified the onset of apoptotic cell death. TAIII-induced autophagy preceded apoptosis, as evidenced by early autophagic vacuole formation, GFP-LC3 translocation, and LC3-II increase in the absence of caspase-3 cleavage. Notably, TAIII-mediated apoptotic cell death was potentiated by treatment with autophagy inhibitor 3-methyladenine or small interfering RNA against the autophagic gene beclin 1. These findings suggest that TAIII-elicited autophagic response plays a protective role that impedes the eventual cell death. In terms of structure-activity relationship, the sugar chain in TAIII is indispensable to the drug action, as the sugar-lacking aglycone sarsasapogenin did not induce autophagy and exhibited weaker cytotoxicity. [Cancer Res 2008;68(24):10229–37]
Two doctors confess to helping patients to die
Authors: C. Dyer
Journal: BMJ (1997)

The highly charged debate over voluntary euthanasia and physician assisted suicide blew up last week when two British doctors confessed to giving lethal doses of drugs to hasten the deaths of terminally ill patients.

Michael Irwin, chairman of the Voluntary Euthanasia Society, told the Sunday Times that he had administered fatal doses to around 50 patients over a 40 year career. Dr Irwin, a retired Sussex GP and former medical director of the United Nations, said that the “double effect principle,” whereby doctors may administer large doses …
Effect of dietary supplementation with eicosapentaenoic acid in the treatment of atopic dermatitis
Authors: A. BJORNEBOE, ELISABETH SOYLAND, GUNN-ELIN A. BJORNEBOE, G. RAJKA, C.A. DREVON
Journal: British Journal of Dermatology (1987)

Journal Article Effect of dietary supplementation with eicosapentaenoic acid in the treatment of atopic dermatitis Get access A. BJØRNEBOE, A. BJØRNEBOE Anders Bjørneboe, National Institute of Forensic Toxicology, P.O. Box 16, Gaustad 0320, Oslo 3 Search for other works by this author on: Oxford Academic Google Scholar ELISABETH SØYLAND, ELISABETH SØYLAND Department of Dermatology, Rikshospitalet, University Hospital and National Institute of Forensic Toxicology, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar GUNN‐ELIN A. BJØRNEBOE, GUNN‐ELIN A. BJØRNEBOE Department of Dermatology, Rikshospitalet, University Hospital and National Institute of Forensic Toxicology, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar G. RAJKA, G. RAJKA Department of Dermatology, Rikshospitalet, University Hospital and National Institute of Forensic Toxicology, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar C.A. DREVON C.A. DREVON Department of Dermatology, Rikshospitalet, University Hospital and National Institute of Forensic Toxicology, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue 4, 1 October 1987, Pages 463–469, https://doi.org/10.1111/j.1365-2133.1987.tb04926.x Published: 01 October 1987
An injection of fear
Authors: T. Dalrymple
Journal: BMJ (2010)

In The Plague , published in 1947, Albert Camus made use of epidemic disease as a metaphor for the Nazi invasion and occupation of France (see Medical Classics, BMJ 2007;335:567, doi:10.1136/bmj.39317.641146.4E). But this was not the first such use of epidemic as metaphor for the occupation: in 1943 Jean-Paul Sartre wrote a film script, Typhus , in which an outbreak of that disease did so.

By the time he wrote Typhus , which was never filmed as written, it was clear that the Germans were not going to win the second world war. Sartre set the action in colonial Malaya, of whose geography he seemed curiously ignorant, apparently believing that the peninsula was …
Lung Function in Infants with Cystic Fibrosis Diagnosed by Newborn Screening
Authors: Barry M. Linnane, Graham L. Hall, Gary Nolan, Siobhan Brennan, Stephen M. Stick, Peter D. Sly, Colin F. Robertson, Philip J. Robinson, Peter J. Franklin, Stephen W. Turner, Sarath C. Ranganathan
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Rationale: Progressive lung damage in cystic fibrosis (CF) starts in infancy, and early detection may aid preventative strategies.Objectives: To measure lung function in infants with CF diagnosed by newborn screening and describe its association with pulmonary infection and inflammation.Methods: Infants with CF (n = 68, 6 weeks to 30 months of age) and healthy infants without CF (n = 49) were studied. Forced vital capacity, FEV0.5, and forced expiratory flows at 75% of exhaled vital capacity (FEF75) were measured using the raised-volume rapid thoracoabdominal compression technique. Forty-eight hours later, infants with CF had bronchoalveolar lavage (BAL) for assessment of pulmonary infection and inflammation.Measurements and Main Results: In the CF group, the deficit in FEV0.5 z score increased by −0.77 (95% confidence interval, −1.14 to −0.41; P < 0.001) with each year of age. The mean FEV0.5 z score did not differ between infants with CF and healthy control subjects less than 6 months of age (−0.06 and 0.02, respectively; P = 0.87). However, the mean FEV0.5 z score was lower by 1.15 in infants with CF who were older than 6 months of age compared with healthy infants (P < 0.001). FVC and FEF75 followed a similar pattern. Pulmonary infection and inflammation in BAL samples did not explain the lung function results.Conclusions: Lung function, measured by forced expiration, is normal in infants with CF at the time of diagnosis by newborn screening but is diminished in older infants. These findings suggest that in CF the optimal timing of therapeutic interventions aimed at preserving lung function may be within the first 6 months of life.
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy
Authors: Norihiko Yokoi, Yuko Fukata, Daisuke Kase, Taisuke Miyazaki, Martine Jaegle, Toshika Ohkawa, Naoki Takahashi, Hiroko Iwanari, Yasuhiro Mochizuki, Takao Hamakubo, Keiji Imoto, Dies Meijer, Masahiko Watanabe, Masaki Fukata
Journal: Nature Medicine (2014)
What's Wrong with This Picture?
Authors: David B. Gilbert
Journal: Annals of Internal Medicine (1998)

Letters15 February 1998What's Wrong with This Picture?David B. Gilbert, MDDavid B. Gilbert, MDLafayette Clinic; Fayetteville, NC 28304Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-4-199802150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As a clinical cardiologist, I couldn't help but bring my issue of Annals home and read the essay by Brody [1] to my wife.“You see, I am not alone after all! Any well-trained physician can find a diseased organ in his own specialty. There are still some doctors who go to bed at night worrying about their patient and the effectiveness of their diagnosis.”“But not as many as there used to be,” she replied. “The other learned professions aren't doing much better. Older attorneys used to solve problems. The new ones seem to stir the ...References1. Brody SA. What's wrong with this picture? Ann Intern Med. 1997; 126:997-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Lafayette Clinic; Fayetteville, NC 28304 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1998Volume 128, Issue 4Page: 324KeywordsSub-specialty care Issue Published: 15 February 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract 2882: CREB inhibition attenuates MM tumor growth and drug resistance
Authors: Arti Shukla, Jedd M. Hillegass, Maximilian B. Macpherson, Stacie L. Beuschel, Chad Steele, Brooke T. Mossman
Journal: Cancer Research (2011)

Abstract Malignant mesothelioma (MM) has a poor prognosis because of its difficult diagnosis and chemoresistance. We have shown previously that cyclic AMP response element binding protein (CREB) is constitutively activated (phosphorylated) in MM cells and tissue arrays as compared to mesothelial cells or benign lesions. Moreover, inhibition of CREB results in increased Doxorubicin (Dox)-induced apoptosis by attenuation of prosurvival genes, Bcl2 and BclxL. Using intraperitoneal and subcutaneous SCID xenograft mice models injected with shCREB (CREB inhibited) human MM cells (Hmeso), we show that CREB inhibition significantly attenuates tumor growth in both models. In addition, CREB inhibition also results in additional decreases in tumor size after treatment with Dox (0.5mg/kg, ip, 3 times a wk for 6 wks), suggesting a role of CREB in drug resistance. TUNEL staining on tumor sections showed increased cell death in CREB-inhibited tumors. Assessment of human cytokine levels by Bioplex analysis in peritoneal lavage fluid (PLF) of tumor-bearing mice showed that CREB inhibition significantly attenuated levels of IL-6, IL-8, VEGF, MCP1, IFN-gamma, IP-10 and RANTES. Dox treatment per se increased levels of several cytokines (IL-6, IL-8, G-CSF, IP-10, MIP-1B, RANTES), however, in the presence of shCREB, these levels were significantly decreased after Dox treatment. Other cytokine levels like bFGF, IFN-gamma, MCP1 and VEGF were reduced following Dox treatment, and further decreases were observed in CREB inhibited (shCREB) tumors. Microarray analysis performed on shCREB-Hmeso cells in vitro showed several fold decreases in various tumorigenesis- related genes including PAK7, Calbindin 1, TIE-2, MCAM, CD24, CCL-5, c-Met, v-kit, MMP2, IL-6, and snail homolog 2 as compared to shControl-Hmeso cells. In addition, increases in mRNA levels of phosphatases, Dachund homolog, and Caspase-1 were also observed following CREB inhibition. The patterns of gene expression and cytokine release by shCREB suggest that CREB affects tumor growth by regulating proliferation/survival, angiogenesis, migration and apoptosis. In addition, we also show that inhibition of CREB expression renders MM tumors more susceptible to Dox. This study is supported by National Cancer Institute grant PO1CA114047 and a grant from the Vermont Genetics Network (VGN). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2882. doi:10.1158/1538-7445.AM2011-2882
Aminophylline in respiratory failure.
Authors: M R Patridge
Journal: BMJ (1978)

disease.The latter disease may be more common than what was conveniently known as Friedlander's pneumonia, due to infection with K edwardsii or K atla7itae, and must be considered in all severe cases of pneumonia.For this reason and for the very wide anti- bacterial spectrum, I would advocate that gentamicin and erythromycin be regarded as the drug combination of choice in the face of fulminating pneumonia, particularly one which is not responding to treatment with a penicillin or tetracycline.The combination of gentamicin and erythromycin not only has the virtue that it will cover almost the whole range of bacterial infections, excluding tuberculosis, but also includes cover for at least some Bacteroides species, which, admittedly, are very rare causes of pneumonia, and will be effective against Mybcoplasrna pneunioniiae infection, though this is rarely the cause of life-threatening disease.The recently suggested alternative' of tetracycline and rifampicin might not have the same wide spectrum cover against Gram- negative bacteria.
Motor responses of human gastrointestinal tract to 5-hydroxytryptamine in vivo and in vitro
Authors: J. J. Misiewicz, S. L. Waller, M. Eisner
Journal: Gut (1966)

EDITORIAL SYNOPSIS This paper reports studies on the effects of serotonin on gastrointestinal motility in vivo and on muscle strips in vitro.Serotonin stimulates upper and lower small intestinal motility but inhibits activity in the stomach and colon.This effect is apparently a direct one on the smooth muscle.These studies fit in well with the observed effect in man in the carcinoid syndrome, as patients with increased urinary excretion of 5HIAA have been shown to have hypermotility of the small intestine and hypomotility of the colon.The alimentary tract is the main source of 5-hydroxy- tryptamine (5HT, serotonin) in the body, but the physiological role of this amine is as yet uncertain.Bulbring and Crema (1958) have shown that 5HT potentiates the peristaltic reflex when applied to the mucosal surface of the guinea-pig ileum in vitro.In man, intravenous injections of serotonin stimulate pressure waves in the jejunum and ileum (Hendrix, Atkinson, Clifton, and Ingelfinger, 1957) but inhibit the distal colon (Fink and Friedman, 1960).It is possible therefore that serotonin causes the ali- mentary symptoms of the carcinoid syndrome.In vitro, 5HT contracts human muscle strips from the small intestine but inhibits strips from the colon (Fishlock and Parks, 1963).The application of in vitro techniques to the study of human alimentary muscle is an important advance, but cannot replace studies in vivo.We have therefore investigated the effect of 5-hydroxytryptamine both in vivo and in vitro on the stomach, small intestine, and colon.In addition, experiments were performed on strips of oesophageal muscle in vitro.We have also recorded the motility of the small intestine and colon in a patient with the carcinoid syndrome. METHODS AND MATERIALS MEASUREMENT OF INTRALUMINAL PRESSURES IN PATIENTSThirty-nine patients were studied.Twenty-two had the irritable bowel syndrome, abdominal pain, or constipation, three had proctitis, three steatorrhoea, and the remaining 11 suffered from a variety of gastrointestinal disorders.No specific trend emerged in any of the diagnostic groups in response to 5HT and the results from all the patients were analysed together.Most patients experienced mild side-effects during the injection of 5HT, 'Present address: Medizinische UniversitAtsklinik, Basel, Switzerland.Period Injection I Control No injection II Placebo N saline, 2 ml./min.intravenously III 5HT 5HT (Sandoz) 0-5 mg./min.intraven- ously.Total dose 4-0 mg.
TCT-258 Impact of the type of the underlying plaque on the neointima tissue developed after a bioresorbable scaffold implantation. A serial optical coherence tomography study
Authors: Yaojun Zhang, Christos Bourantas, Roberto Diletti, Vasim Farooq, Hector M. Garcia-Garcia, Yoshinobu Onuma, Patrick Serruys
Journal: Journal of the American College of Cardiology (2012)
Successful corticosteroid therapy for epoetin‐β‐induced pure red‐cell aplasia in a hemodialysis patient
Authors: Simona Zerbi, Giorgio Cozzi, Angelo Mercieri, Pietro Faranna, Pio Ruggiero, Luciano A. Pedrini
Journal: American Journal of Hematology (2006)

A recent article in Blood, ''How I Treat Idiopathic Thrombocytopenic Purpura (ITP)'' by Cines and Bussel, was read with great interest [1].Placing in perspective the new treatment modalities is useful to all hematologists, yet the only published data the authors cited to support their recommendations were a meta-analysis of patients with platelet counts below 30,000, which did not differentiate between treated and untreated patients.There are no publications extant that suggest that treatment-naive, otherwise healthy adult ITP patients with any platelet count are at risk for significant bleeding.In 1988, Brox et al. showed a significant rise in the platelet count with high doses of ascorbic acid in refractory ITP patients [2].Subsequent to Brox's report a study of ascorbic acid for the treatment of refractory ITP was published by Jubilirer [3], which failed to confirm Brox's data; however, it is to be noted that no bleeding episodes occurred in the treatment arm.In 1983 Burns and Saleem [4] published a review of the natural history of refractory ITP patients (steroid and splenectomy failures) and concluded that significant hemorrhagic events were extremely rare.In 2001 Vianelli et al. [5] reported on the long-term follow-up of 310 patients with ITP and concluded that ''prospective studies are required to evaluate whether it may be reasonable to treat only symptomatic patients independently of age.''Since 1988 (Auerbach), steroids have not been used in any of more than 40 patient referrals irrespective of platelet counts without thrombocytopenia-related morbidity.For platelet counts > 10,000, vitamin C alone was prescribed and bruising was virtually eliminated.This result is not unexpected inasmuch as improvement in capillary fragility and wound healing are well-recognized salutary effects with vitamin C. For counts < 10,000 WinRho and/or Rituxan has been universally successful.Therefore, it may not be unreasonable to suggest that our conventional approach to managing ITP in otherwise healthy adults (corticosteroids/ splenectomy) must be reexamined.Even in the pre IVIG, WinRho, and Rituxan era, bleeding was rarely encountered during splenectomies in ''refractory'' ITP patients.Our most important admonition, ''before else, do no harm,'' should be heeded before recommending potentially toxic therapies.