Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer
Authors: Yosef Dror, Felicia Stern
Journal: Annals of Internal Medicine (2014)

Letters6 May 2014Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and CancerYosef Dror, PhD and Felicia Stern, PhDYosef Dror, PhDFrom Institute of Biochemistry, Food Science and Nutrition, The Hebrew University, Rehovot, Israel.Search for more papers by this author and Felicia Stern, PhDFrom Institute of Biochemistry, Food Science and Nutrition, The Hebrew University, Rehovot, Israel.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5009-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Fortmann and colleagues’ (1) conclusion that “we found no consistent evidence that the included supplements affected [cardiovascular disease], cancer, or all-cause mortality in healthy individuals without known nutritional deficiencies” is not well-supported because the evaluated studies have major shortcomings. The “multivitamin” preparations contained unbalanced formulations with some amounts higher than the U.S. recommended dietary allowance by manifold. The upper tolerable limits evaluated by the authors are unreliable and have never been proved by lengthy clinical trials. In 1 study, elderly participants (aged >60 years) received iron supplements, which might induce an oxidative state in many persons. β-Carotene ...Reference1. Fortmann SP, Burda BU, Senger CA, Lin JS, Whitlock EP. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: an updated systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2013;159:824-34. [PMID: 24217421] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Institute of Biochemistry, Food Science and Nutrition, The Hebrew University, Rehovot, Israel.Disclosures: None. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0084. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoVitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force Stephen P. Fortmann , Brittany U. Burda , Caitlyn A. Senger , Jennifer S. Lin , and Evelyn P. Whitlock Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Sebastian J. Padayatty and Mark Levine Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Harri Hemilä Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Mark J. Bolland , Andrew Grey , and Ian R. Reid Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Stephen P. Fortmann , Evelyn P. Whitlock , and Brittany U. Burda Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Harri Hemilä Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Mark J. Bolland , Andrew Grey , and Ian R. Reid Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Stephen P. Fortmann , Evelyn P. Whitlock , and Brittany U. Burda Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Sebastian J. Padayatty and Mark Levine Metrics 6 May 2014Volume 160, Issue 9Page: 654KeywordsCancer preventionCardiovascular diseasesClinical trialsDisclosureElderlyMalnutritionMorbidity ePublished: 6 May 2014 Issue Published: 6 May 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...