tbuckley/cabot-search huggingface dataset:
Gastroenteritis causing failure of oral contraception.
Authors: A H John, A J Jones
Journal: BMJ (1975)

Vincristine-induced Autonomic NeuropathyNeurological adverse effects are known to complicate vincristine treatment.In occasional reports of bowel and bladder disturbance it has not been possible to incriminate autonomic neuropathy.We report here three patients with symptoms and signs which could be ascribed to vincristine-induced autonomic neuropathy. Case ReportsCase 1.-A 75-year-old man presented with recurrent Hodgkin's disease.Chemotherapy with modified MOPP (intravenous mustine 6 mg/M2 and vincristine (Oncovin) 1 4 mg/M2 on days 1 and 8; oral procarbazine 100 mg/ m2 and prednisolone 40 mg/day for 14 days; 28 days between each course) was started.About 10 days after his first course he developed symptomatic postural hypotension, his blood pressure being 110/80 mm Hg lying and 70/40 mm Hg standing.The Valsalva response was characteristic of auto- nomic neuropathy.He also had marked peripheral neuropathy.Slow spon- taneous improvement occurred and chemotherapy was resumed using vinblastine instead of vincristine.Case 2.-A 77-year-old man presented with diffuse lymphocytic lymphoma.Cyclical chemotherapy was begun with COPAd (intravenous cyclophos- phamide 400 mg/M2 and vincristine 1-4 mg/M2 on days 1 and 8; oral predni- solone 40 mg/day for 14 days; intravenous adriamycin 40 mg/M2 on day 1; 28 days between each course).One week after his first course he developed severe postural hypotension (blood pressure 160/80 mm Hg lying and 90/50 mm Hg standing).The Valsalva response was abnormal.Over the next few days he also developed peripheral neuropathy.His symptoms improved over the next two weeks and chemotherapy was continued using vinblastine instead of vincristine.Case 3.-A 56-year-old man presented with generalized Hodgkin's disease and received three rourses of modified MOPP.He was admitted with generalized weakness, constipation, and retention of urine.Clinical and radiological examination showed paralytic ileus.His blood pressure was 110/70 mm Hg lying and 80/20 mm Hg standing.Myoclonic jerks were observed and he had an extensive peripheral neuropathy.Spontaneous improvement occurred over three to four weeks.Chemotherapy was restarted, substituting vinblastine for vincristine, but he diecL.ofsepticaemia.
Expansion of Renewable Energy Industries and Implications for Occupational Health
Authors: Steven A. Sumner
Journal: JAMA (2009)

RECENT PASSAGE OF THE AMERICAN RECOVERY AND Reinvestment Act of 2009 provides significantly increased funding for renewable energy industries that are expected to increasingly supplant the traditional fossil fuel energy industries of coal, oil, and natural gas. Although fossil fuel energy has historically been priced lower than renewable energy, hidden costs to energy production have not been fully included or internalized in the market price of fuel, thereby distorting true costs. These additional costs are known as externalities of energy. One such externality of energy is adverse effects on human health. Human health problems associated with high carbon dioxide emissions from energy production have largely been described as resulting from air pollution; spread of vector and waterborne infectious diseases; flood, drought, and malnutrition; and deaths due to terrorist attacks and military intervention. A reduction in these problems has been touted as an important benefit of a transition to renewable energy. However, benefits to US energy workers in the form of reduced workplace injury and fatality have been an underemphasized advantage of change in energy policy. Study of fuel externalities has led to methodological approaches that consider the entire fuel life cycle: fuel extraction, other raw material extraction, structure construction, equipment manufacturing, material transport, energy generation, power distribution, and by-product disposal. The major segments of the fuel cycle are a useful framework for considering available occupational health evidence comparing fossil fuel energy with 3 renewable energies with significant potential for growth: wind, solar, and biomass.
Comparison of clinical tests and the KT1000 in the diagnosis of anterior cruciate ligament rupture.
Authors: G P Graham, S Johnson, C M Dent, J A Fairclough
Journal: British Journal of Sports Medicine (1991)

A prospective study was undertaken to compare the accuracy of the Lachman test, anterior drawer test and jerk test with the KT1000 knee arthrometer in patients with proven anterior cruciate ligament deficiency. The Lachman and anterior drawer tests were found to be the most accurate indicators of anterior cruciate ligament deficiency. The KT1000 knee arthrometer was found to be totally inaccurate, which precludes its use as an objective measure of anteroposterior laxity of the knee.
Two Cases of Non–Small-Cell Lung Cancer with Rare Complex Mutation of EGFR Exon 18 But Different Response to Targeted Therapy
Authors: Hélène Gauthier, Gaelle Douchet, Jacqueline Lehmann-Che, Véronique Meignin, Christine Raynaud, Pierre Sabatier, Hubert de Cremoux, Brigitte Poirot, Stéphane Culine, Damien Pouessel, Patricia de Cremoux
Journal: Journal of Thoracic Oncology (2014)
Smoking, sugar, and inflammatory bowel disease.
Authors: J R Thornton, P M Emmett, K W Heaton
Journal: BMJ (1985)

Etude sur 30 sujets atteints de colite ulcerative, 30 atteints de maladie de Crohn et autant de temoins normaux. Une correlation positive semble exister entre la maladie de Crohn et le tabagisme, independante de celle deja connue avec la consommation de sucre raffine. Quant a la colite ulcerative les malades sont 3 fois moins souvent des fumeurs que les temoins, mais 7 fois plus souvent d'anciens fumeurs ayant abandonne le tabac. Il semble que le fait de fumer donne une certaine protection vis-a-vis de la colite ulcerative, mais augmente le risque de maladie de Crohn
Learning by experience.
Authors: N. F. Metcalf, W. K. Metcalf
Journal: BMJ (1989)

non-traumatic accidents such as near drownings, burnings, and electrocutions.The immediate management priorities are similar in both groups,' so there is nothing to be gained by dividing them between two specialties.Resuscitation of injured patients is the forte of the accident and emergencv specialist.How well it is being carried out will become apparent through studies of the outcome of trauma and audit systems in which accident and emergency staff are prominent participants.
Advice to Authors-Reply
Authors: M. Therese Southgate
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The items in question were not strictly references, in that many of them were not<i>referred to</i>in the contribution. Therefore, "References" was considered, but dropped, since it was an inappropriate term. As Dr. Thompson notes, a bibliography is a list of writings on a subject, each of which, presumably, has been read by the person who names them. Since all of these works were read by the author, the term "Bibliography" was used. The term "Selected" was added to denote the incompleteness of the list. If my memory serves me,<i>The Elements of Style</i>also says, "Be obscure clearly."
Object of State Regulation of Practice.
Authors: H. C. Markham
Journal: JAMA (1889)

<h3>Dear Sir:</h3> —It is doubtful if all other combined opposition to medical legislation has, or still exerts, effects equally fatal to its success, as the one false and mistaken idea that it is chiefly in the interest of the profession itself. It has been the great argument of every nostrum nabob and medical fraud, which the promoters of medical legal reform have been compelled to confront. But when the friends and advocates of such reform in the profession, so far misinterpret its true animus, purpose and operation, as to indorse this fatal error, one is scarcely able to repress an indignant protest. A medical society at Green Bay, Wis., in a recent report of its action, saw fit to rise from its average to aid in lifting a medical act through the General Assembly of that State the following: " Whereas, for the better protection of the medical profession," etc. Permitting
Distribution and Degradation Studies with Insulin-I131†
Authors: Neil J. Elgee, Robert H. Williams, Norman D. Lee
Journal: Journal of Clinical Investigation (1954)

Diabetes mellitus is of obscure etiology, often presenting profound metabolic derangement with a sparsity of morphopathologic change.Insulin reverses many of the metabolic changes, yet its mechanism of action is poorly understood; fur- thermore, in most patients with diabetes mellitus, the fundamental causes of the insulin insufficiency are not known.An important approach to this challenging problem is the study -of insulin metab- olism.Such a study has been hampered by un- satisfactory assay techniques, and, as a-result, very little is known even of the fate of insulin.The use of labeled hormone greatly facilitates such a study, and, in this report, the validity of such an ap- proach is considered, and distribution and degradation studies using I'8l-labeled insulin are described. METHODS AND MATERIALSInsulin-I' Crystalline zinc insulin 8 was labeled with I', either by the method of Ferrebee, Johnson, Mithoefer, and Gar- della (1), or by a method of the Abbott laboratories.Specific activity ranged from 4 to 1008 i'c per mg.The radioactivity of the insulin-I' stayed with the protein fraction in trichloracetic acid precipitation, in dialysis, and in chromatography.4It had the same mobility as un- labeled insulin in paper electrophoresis (2).The potencies of three different lots of insulin-I', two prepared by the Ferrebee technique, and one by the Abbott method, were tested in the acceleration of the glucose uptake of rat diaphragm in vitro.Each determination
Experts Try Education to Preserve Skiers' Knees
Authors: Andrew A. Skolnick
Journal: JAMA (1996)

BY TOO many accounts, one of the most horrible sounds a skier can hear on a ski slope is the popping noise of the anterior cruciate ligament (ACL) as it tears during a fall. That sound, which usually heralds a painful, debilitating, and expensive knee injury, is heard no less by the most accomplished skiers than by the clumsiest novices. Severe knee sprains are now the most common medically significant injuries among Alpine or downhill skiers. While improvements in ski boots and bindings since the 1970s have greatly reduced fractures and other injuries below the knee, they appear to have done nothing to protect skiers from serious ACL injuries. According to several studies, the rate of severe knee sprains—which usually involve the ACL—has increased more than threefold since the late 1970s. Now, researchers who have spent more than two decades studying video tapes of ski injuries have developed an educational
Local Pulmonary Immunity in Pigeon Breeder's Disease
Authors: MARK R. SCHUYLER
Journal: Annals of Internal Medicine (1978)

We studied pulmonary and systemic aspects of the immune response in a patient with pigeon breeder's disease before and after an inhalation challenge with pigeon serum. Macrophage migration inhibition was induced with bronchoalveolar wash cells exposed to both pigeon serum and pigeon dropping extract before but not after challenge. Peripheral blood lymphocytes exposed to these antigens did not induce inhibition of guinea pig peritoneal macrophage migration before challenge. However, after challenge peripheral blood lymphocytes did cause macrophage migration inhibition when exposed to pigeon serum. Both systemic and bronchoalveolar lymphocytes proliferated when exposed to these pigeon antigens in vitro. Our patient represents the first reported case of lymphokine production by pulmonary as well as systemic lymphocytes in hypersensitivity pneumonitis.
Heat Probe Therapy for Severe Hemorrhage from a Peptic Ulcer with a Visible Vessel
Authors: H. J. Lin, Y. T. Tsai, S. D. Lee, K. H. Lai, C. H. Lee
Journal: Endoscopy (1988)

Over a period of 9 months we treated 50 patients with upper gastrointestinal bleeding from a peptic ulcer with a visible vessel. Their mean age was 58.8 years. Almost all cases had massive bleeding and required an average of 1930 ± 2174 ml (S. D.) of blood. Twenty-eight cases were in shock when treated. The lowest mean hemoglobin was 8.2 ± 2.2 gm/dl (S. D.). We treated them with the Olympus GIF-1T10 and the heat probe unit. A total of 825 ± 735 joules (S. D.) were applied to each bleeder. Forty-nine cases (98 %) stopped bleeding after initial treatment. Seven cases (14.3 %) rebled within one week post-treatment. We tried heat probe therapy again in 6 of the cases that rebled, and achieved hemostasis in four of them. Ultimately, only four failures were seen in our study. The success rate was 92 % (46/50). We conclude that thermocoagulation with the heat probe may in the near future replace surgery in the majority of cases of hemorrhage from a peptic ulcer with a visible vessel in its base.
Cyanotic Malformations of the Heart with Pheochromocytoma
Authors: GORDON M. FOLGER, WILLIAM C. ROBERTS, ALI MEHRIZI, K. D. SHAH, D. L. GLANCY, CHARLES C. J. CARPENTER, JOHN R. ESTERLY
Journal: Circulation (1964)

The clinical and pathologic features of five patients with pheochromocytoma associated with congenital cyanotic cardiac malformations have been described. This association appears to be more than mere coincidence. Chronic hypoxemia may be a significant factor in the development of this rare endocrine tumor in such patients. The finding of systemic hypertension combined with episodes of nervousness and sweating or repeated severe headaches initially aroused suspicion of a pheochromocytoma in the three patients in which this tumor was diagnosed clinically.
335 FIBROINDEX (NONINVASIVE MARKERS OF LIVER FIBROSIS) CAN PREDICT HCC DEVELOPMENT AND MORTALITY IN PATIENTS WITH CHRONIC HEPATITIS C
Authors: M. Koda, Y. Fujise, S. Tokunaga, M. Kishina, J. Kato, T. Matono, Y. Murawaki
Journal: Journal of Hepatology (2011)
The Copper Intrauterine Device and Its Mode of Action
Authors: Gerald Oster, Miklos P. Salgo
Journal: New England Journal of Medicine (1975)

OF all the contraceptive methods developed in the past five years, perhaps the most widely used is the copper intrauterine device. Copper metal in contact with biologic substrates is highly reactive. The copper ions thereby produced also have biologic effects. Thus, this device is a pharmacologic agent.Development and Clinical Aspects of the Copper Intrauterine DeviceIn 1969, Zipper et al. found that copper wire when placed in the uterus of the rabbit has a contraceptive effect.1 This discovery was applied to human beings.2 A plastic T-shaped device with copper wire wound around its stem had an increased contraceptive effect . . .
Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42
Authors: Irina Pleines, Sebastian Dütting, Deya Cherpokova, Anita Eckly, Imke Meyer, Martina Morowski, Georg Krohne, Harald Schulze, Christian Gachet, Najet Debili, Cord Brakebusch, Bernhard Nieswandt
Journal: Blood (2013)
Ventilation-Perfusion Mismatch Secondary to Arterial Bullet Embolism
Authors: Mehmet Reyhan, Mehmet Aydin, Aysun Sukan, Dalokay Kilic, A Fuat Yapar, Fahri Tercan
Journal: Clinical Nuclear Medicine (2007)

A 19-year-old man who was brought to the emergency department after a gunshot injury was referred to the radiology department to obtain computed tomography (CT). His CT findings revealed the appearance of a bullet in the truncus arteriosus, and he was urgently sent for operation. However, the bullet was not found during the operation and his control CT and chest x-ray detected a bullet in his right pulmonary artery and a very dense opacity in the lower zone of the right lung. He was then referred to our department for ventilation-perfusion scintigraphy. Ventilation-perfusion imaging revealed a large segmental ventilation perfusion mismatched defect in the lateral basal segment of the right lower lobe.
Report Quantifies Diabetes Complications
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
S28 Is a pulmonary rehabilitation programme for patients undergoing curative lung cancer surgery feasible?
Authors: A. Bradley, J. Gillies, K. Parker, P. Agostini, L. Stone-hewer, E. Bevan-Smith, E. Bishay, M. Kalkat, R. Steyn, P. Rajesh, B. Naidu
Journal: Thorax (2011)

<h3>Introduction and objectives</h3> The new BTS lung cancer surgery guidelines mention patient optimisation to reduce risk. Our aim was to develop a multi-stranded pragmatic rehabilitation programme for this group of patients, apply it in a pilot study and look at feasibility, process indicators, outcome measures, local adaptability, compliance and potential cost benefit. <h3>Methods</h3> An outpatient based complex intervention was developed by doctors, allied health professional and patients to optimise physical status, prepare for inpatient journey and support through recovery after surgery. Tested in an enriched cohort study over 11 months 45 patients received the intervention compared to 198 who received standard care. <h3>Results</h3> Potential surgical candidates at a regional thoracic unit were identified early at lung cancer multidisciplinary team meetings and enrolled on a COPD-type rehabilitation programme which included exercise classes, smoking cessation, dietary advice and patient education. Patients attended exercise classes twice a week until surgery, (which was not delayed). On average patients waited 7 days (range 0–29) to be seen in a rehabilitation class and attended on 5 sessions (range 1–12) resulting in 39 m improvement in 6-minute walk test. The education classes were delivered by lung cancer nurse and addressed diet, smoking, lifestyle change, inpatient expectations, preparation for discharge, and pain management. Six patients identified as potentially or at risk of being malnourished received nutritional supplementation. 5 out of 10 current smokers agreed to be fast tracked into locally available smoking cessation pathways and were biochemically proven to have given up. In the two referring hospitals one delivered classes in outpatient individualised setting while the other in community based group class. An additional four patients following further investigations did not receive surgery. Both groups were matched for age, lung function comorbidity and type of surgery and outcomes are presented in Abstract S28 table 1. The intervention resulted in cash releasing saving to the PCT of £938 per patient. <h3>Conclusion</h3> A viable outpatient based complex intervention pathway of enhanced recovery/pulmonary rehabilitation has been developed and tested. Initial results are promising but a multicentre randomised controlled trial is warranted to test efficacy.
Clinicopathologic Significance of Defective DNA Mismatch Repair in Endometrial Carcinoma
Authors: Destin Black, Robert A. Soslow, Douglas A. Levine, Carmen Tornos, Shirley C. Chen, Amanda J. Hummer, Faina Bogomolniy, Narciso Olvera, Richard R. Barakat, Jeff Boyd
Journal: Journal of Clinical Oncology (2006)

Purpose Defective DNA mismatch repair is commonly present in sporadic manifestations of gastrointestinal, endometrial, and other cancers. The pathognomonic molecular manifestation of this repair defect is microsatellite instability (MSI). Here, we test the hypothesis that MSI predicts the clinicopathologic features of endometrial carcinoma. Patients and Methods A retrospective cohort of 473 patients treated for endometrial carcinoma at this institution was identified. All cases were reviewed by a gynecologic pathologist, and clinical information was abstracted from medical records. Using consensus criteria, DNA samples from nontumor and tumor tissue pairs were genotyped for MSI. Associations between MSI status and pathologic and clinical variables were assessed. Results Ninety-three (20%) of 473 tumors were MSI+. In the MSI+ tumor group compared with the MSI− tumor group, the proportion of advanced compared with early-stage tumors was higher (92% v 81%; P = .01), as was the proportion of tumors of endometrioid compared with nonendometrioid histologic subtype (94% v 23%; P = .001), and the proportion of tumors with myometrial invasion compared with those with none (92% v 78%; P = .01). By multivariate analyses, disease-free survival (hazard ratio, 0.3; 95% CI, 0.2 to 0.7) and disease-specific survival (hazard ratio, 0.3; 95% CI, 0.1 to 0.8) were significantly improved in patients with MSI+ tumors. Conclusion In endometrial carcinoma, the presence of MSI was independently associated with a more favorable clinical outcome.
Before the internet: Medical advice for the world
Authors: P. Bemrose
Journal: BMJ (1997)

A medical consulting room literally at the disposal of the world is an idea which is to be put into practice by the Italian “Direzione Generale di Sanita.” The proposal was recently put to Signor Mussolini, and the Duce immediately gave a warm assent, with the result that a unique medical institution will open in the near future.

The consulting room is to …
The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition
Authors: Angela G. Fleischman, Julia E. Maxson, Samuel B. Luty, Anupriya Agarwal, Lacey R. Royer, Melissa L. Abel, Jason D. MacManiman, Marc M. Loriaux, Brian J. Druker, Jeffrey W. Tyner
Journal: Blood (2013)
Evaluation of Silicone as an Artificial Lubricant in Osteoarthrotic Joints
Authors: V. Wright, D. I. Haslock, D. Dowson, P. C. Seller, B. Reeves
Journal: BMJ (1971)

Silicone 300 has been evaluated as an artificial lubricant in osteoarthrotic joints by means of a pilot study in five inpatients and a control trial of 25 outpatients with 40 osteoarthrotic knees. Sequential analysis showed a significant benefit from saline compared with silicone at one week follow-up and no significant difference at one month. Measurement of stiffness with a knee arthrograph showed no difference in reduction of stiffness between the two substances. In a study of 18 rabbits there was no evidence that silicone was retained in the joint cavity for longer than 48 hours. There was a failure of clearance of iodinated serum albumin for as long as three to four days after the injection of silicone, suggesting some obstruction to lymphatic outflow. Experimentally produced cartilaginous defects did not heal quicker with the injection of silicone into the joint.