Possible Ranitidine Hepatotoxicity
Authors: MARTIN BLACK
Journal: Annals of Internal Medicine (1984)

Brief Reports1 August 1984Possible Ranitidine HepatotoxicityMARTIN BLACK, M.D., WILBERT E. SCOTT Jr., M.D., ROBERT KANTER, M.D.MARTIN BLACK, M.D., WILBERT E. SCOTT Jr., M.D., ROBERT KANTER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-2-208 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRanitidine (Zantac; Glaxo Incorporated, Research Triangle Park, North Carolina) is a newly introduced H2-receptor antagonist approved by the Food and DrugAdministration for short-term oral use in the treatment of duodenal ulcer and for unrestricted use in hypersecretory states such as the Zollinger-Ellison syndrome (1). Although increased serum aminotransferase levels have been found with parenteral administration of the drug (and are mentioned in the manufacturer's package insert) (2), few reports of clinical hepatotoxicity during therapy with the oral preparation have appeared despite widespread use of the drug in Europe, Australia, and Canada (3, 4). We report the occurrence of symptomatic...References1. Ranitidine (Zantac). Med Lett Drugs Ther. 1982;24:111-3. MedlineGoogle Scholar2. COHENFABRE AL. Tolerance to replaced intravenous doses of ranitidine HCl and Cimetidine HCl in normal volunteers. Curr Ther Res. 1983;34:475-82. Google Scholar3. BARRPIPER GD. Possible ranitidine hepatitis. Med J Aust. 1981;2:421. CrossrefMedlineGoogle Scholar4. CLEATOR I. Adverse effects of ranitidine therapy [Letter]. Can Med Assoc J. 1983;129:405. MedlineGoogle Scholar5. BLACK M. Drug induced liver disease. Postgrad Med J. 1983;59(suppl 4):116-22. MedlineGoogle Scholar6. MCCARTHY D. Ranitidine or Cimetidine. Ann Intern Med. 1983;99:551-3. LinkGoogle Scholar7. KOPELMANSCHEUERWILLIAMS HPR. The liver lesion of the Epping jaundice. Q J Med. 1966;35:553-64. Google Scholar8. McGiLLMOTTO DJ. An industrial outbreak of toxic hepatitis due to methylenedianiline. N Engl J Med. 1974;291:278-82. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Temple University School of Medicine Philadelphia, Pennsylvania; Amarillo, Texas; and Seattle, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration micePreventative and Therapeutic Potential of Flavonoids in Peptic UlcersRanitidine Induced Hepatotoxicity: A ReviewLiver Disease Caused by DrugsInflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal ModelsClinical significance of elevated alanine aminotransferase in blood donors: a follow-up studyRanidil 66337-59-3Possible Ranitidine-Induced Cholestatic JaundiceNephrotoxicity and Hepatotoxicity of Histamine H2 Receptor AntagonistsAcute liver injury associated with the use of ebrotidine, a new H 2 -receptor antagonistPossible Cholestatic Injury From Ranitidine With a Review of the LiteraturePotentiation of carbon tetrachloride-induced liver damage by dibutylyl-3',5'-cyclic AMP in unstarved ratsFamotidine lessens carbon tetrachloride-induced liver damage in rats: A possible implication in lessening volatile anesthetics-induced liver damageSafety of acid-suppressing drugsHepatitis following Treatments with Famotidine and Then CimetIDINEFamotidine-Induced Mixed Hepatocellular JaundiceChange in Prescribing Patterns of Intravenous Histamine 2 -Receptor Antagonists Results in Significant Cost Savings without Adversely Affecting Patient CareSide effects of stress bleeding prophylaxisCyclosporin A and Drug Interaction8 Acute and chronic drug-induced hepatitis9 Drug-induced cholestasisZaltidine: An Effective but Hepatotoxic H 2 -Receptor AntagonistHepatotoxic and hepatoprotective potential of histamine (H2)-receptor antagonistsDrug-Induced CholestasisEffects of three H2 antagonists on the isolated perfused rat liverGastrointestinal drugsEffects of H 2 -Receptor Antagonists on the Rat Liver after Partial Hepatectomy or Carbon Tetrachloride-Induced Hepatic InjuryRanitidine and HepatitisGEORGE N. KARACHALIOS, M.D.RANITIDINE HEPATOTOXICITY IN RENAL TRANSPLANT PATIENTRanitidine and HepatotoxicityDAVID Y. GRAHAM, M.D., ANTONE R. OPEKUN, P.A., J. LACEY SMITH, M.D., JIM T. SCHWARTZ, M.D.RANITIDINE AND HEPATOTOXICITYRanitidine, Acetaminophen, and HepatotoxicityJAMES E. BREDFELDT, M.D., CHRISTIAN VON HUENE, M.D.Drugs Recently Released in Belgium 1 August 1984Volume 101, Issue 2Page: 208-210KeywordsAminotransferasesDrug administrationDrug therapyDuodenal ulcersFood and Drug AdministrationOral administrationPharmacologyZollinger Ellison syndrome Issue Published: 1 August 1984 PDF DownloadLoading ...