tbuckley/cabot-search huggingface dataset:
Studies of Tissue Response to Injections of Enzymes
Authors: SAMUEL THEODORE SCHLAMOWITZ, ARTHUR C. DEGRAFF, MAXWELL SCHUBERT
Journal: Circulation (1950)

Hexosamine-containing polysaccharides have been demonstrated in plasma and various tissues including skin, cartilage and heart. Plasma hexosamine elevations have been observed in rheumatic fever, sterile infarcts and tuberculosis. It is possible that plasma polysaccharide changes reflect alterations of tissue polysaccharides. Thirty-six hours following a single subcutaneous injection of trypsin, a significant elevation of tissue hexosamine occurred at the injection sites. This appeared long before any visible or palpable change. The tissue hexosamine paralleled the developmental course of the "nodules." These findings appear specifically related to trypsin, since they failed to occur with other enzymes or test substances.
308 TUMOR-INFILTRATING REGULATORY T CELLS FAVOR TUMOR DEVELOPMENT BY SUPPRESSING LOCAL TUMOR-SPECIFIC T CELL RESPONSES IN PRIMARY AND METASTATIC LIVER CANCER
Authors: A. Pedroza-Gonzalez, C. Verhoef, J.N. Ijzermans, M. Peppelenbosch, J. Kwekkeboom, H.L. Janssen, D. Sprengers
Journal: Journal of Hepatology (2012)
A Molecular Star in the Wars against Cancer
Authors: Robert Schwartz
Journal: New England Journal of Medicine (2002)

Eons ago, a retrovirus hijacked a gene from a chicken cell and enclosed it within its own genome. The captured gene was not idle, however: it gave the renegade virus the ability to cause tumors in chickens with amazing rapidity. The virus is the Rous sarcoma virus, the gene in the virus is called v-src, and the cellular gene is c-src. These discoveries shifted the tectonic plates of cancer research, thereby opening a new continent for exploration. The subsequent finding that v-src is a tyrosine kinase run wild substantiated the theory that cancer can originate from an unregulated cellular . . .
DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications
Authors: Hsin-An Hou, Yuan-Yeh Kuo, Chieh-Yu Liu, Wen-Chien Chou, Ming Cheng Lee, Chien-Yuan Chen, Liang-In Lin, Mei-Hsuan Tseng, Chi-Fei Huang, Ying-Chieh Chiang, Fen-Yu Lee, Ming-Chih Liu, Chia-Wen Liu, Jih-Luh Tang, Ming Yao, Shang-Yi Huang, Bor-Sheng Ko, Szu-Chun Hsu, Shang-Ju Wu, Woei Tsay, Yao-Chang Chen, Hwei-Fang Tien
Journal: Blood (2011)
Protective effect of methylprednisolone sodium succinate on the ultrastructure and resting tension of hypoxic heart muscle
Authors: W. G. NAYLER, C. YEPEZ, A. GRAU, A. SLADE
Journal: Cardiovascular Research (1978)

Experiments were undertaken to further investigate the protective effect of methylprednisolone sodium succinate on hypoxic heart muscle. Hypoxia was induced in isolated Langendorff perfused rat and rabbit hearts by gassing the perfusate with 95% N2 + 5% CO2. The hypoxia-induced damage was quantitated in terms of an altered ultrastructure and increased resting tension. When added at the start of the hypoxic episode 6 X 10(-5) mol.litre-1 methylprednisolone sodium succinate protected the fine ultrastructure of the heart, and delayed the increase in resting tension. This protective effect could not be accounted for in terms of the sodium succinate moiety.
Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism
Authors: Shozo Yano, Toshitsugu Sugimoto, Tatsuo Tsukamoto, Kazuo Chihara, Akira Kobayashi, Sohei Kitazawa, Sakan Maeda, Riko Kitazawa
Journal: Kidney International (2000)
Abstract 1083: Caveolin-1 in cutaneous squamous cell carcinoma development
Authors: Casey Trimmer, Sanjay Katiyar, Richard G. Pestell, Michael P. Lisanti, Franco Capozza
Journal: Cancer Research (2011)

Abstract Caveolin-1 (Cav1) is the main protein component of a specialized form of lipid raft termed caveolae and serves to compartmentalize and negatively regulate the activity of signaling molecules involved in cell proliferation and survival. Cav1 has been shown to act as a tumor suppressor in several types of cancer, including breast cancer and melanoma, but its role in the pathogenesis of non-melanoma skin cancer remains largely unexplored. Previous work has indicated that Cav1 is expressed in the basal cell layer of both murine and human epidermis; additionally, loss of Cav1 protein has been shown by our lab to render murine skin more susceptible to papilloma development following treatment with a carcinogenic compound. The purpose of the current study was to further examine the role of Cav1 in non-melanoma skin cancer development using various experimental approaches. Given the previous research, our hypothesis is that Cav1 acts as a suppressor of tumor growth and development in the skin. In order to explore this hypothesis, we have used several experimental systems, including human tissue arrays and loss of function and gain of function studies in animal models of cutaneous squamous cell carcinoma. Manipulation of Cav1 expression in (1) a keratinocyte cell line followed by xenotransplantation and (2) an induced model of skin cancer allowed us to assess the effect of this protein on tumor development, growth, and progression. Using these approaches, we were able to show that Cav1 ablation dramatically increases not only in vitro cell growth and invasion, but also in vivo tumorigenesis, tumor growth, and invasion. In conclusion, these studies provide further evidence in support of the hypothesis that Cav1 acts as a tumor suppressor protein in the skin and serve to identify new potential therapeutic targets in the treatment of cutaneous malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1083. doi:10.1158/1538-7445.AM2011-1083
THE PHYSICAL AND PATHOLOGICAL CONDITIONS GOVERNING THE PATTERN DISTRIBUTION OF CUTANEOUS REACTIONS.*
Authors: H. G. ADAMSON
Journal: British Journal of Dermatology (1924)

Journal Article THE PHYSICAL AND PATHOLOGICAL CONDITIONS GOVERNING THE PATTERN DISTRIBUTION OF CUTANEOUS REACTIONS. Get access H. G. ADAMSON, M.D., F.R.C.P. H. G. ADAMSON, M.D., F.R.C.P. Physician in Charge, Skin Department, St. Bartholomew's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 36, Issue 1, 1 January 1924, Pages 1–13, https://doi.org/10.1111/j.1365-2133.1924.tb09129.x Published: 01 January 1924
Heart attacks and homocysteine
Authors: I. Graham, R. Meleady
Journal: BMJ (1996)

It is now accepted that an elevated plasma concentration of homocysteine is a risk factor for atherosclerotic vascular disease affecting the coronary, cerebral, and peripheral arteries.1 Prospective data2 3 4 confirm the findings of casecontrol studies5 6 7 8 and indicate that an elevated plasma homocysteine concentration precedes the development of disease and that there is a dose-response effect.

A 5 μmol/l increase in plasma homocysteine concentration has been estimated to raise the risk of coronary heart disease by as much as an increase in serum cholesterol concentration of 0.5 mmol/l.1 Data from the European Union concerted action project, a case-control study of 750 patients with vascular disease and 800 controls, indicate that a plasma homocysteine concentration above 12 μmol/l (the top fifth of the control distribution) doubles the risk of myocardial infarction and cerebral or peripheral vascular disease in both men and women.9 Additional patients at high risk can be identified by stressing the methionine pathway by means of a methionine loading test, analogous to a glucose tolerance …
Colonic Localization Of Labeled Leukocytes In Critically III Patients
Authors: MARK A. NATHAN, JAMES E. SEABOLD, BRUCE P. BROWN, DAVID L. BUSHNELL
Journal: Clinical Nuclear Medicine (1995)

This study assesses the causes of colonic localization of labeled white blood cells (WBCs) in critically III patients who had undergone leukocyte scintigraphy for suspected infection. Forty-two patients showed abdominal or pelvic WBC localization; 20 of these had a pattern of colonic localization, and some also showed a pattern of small bowel activity. Eight of the 20 patients had documented gastrointestinal bleeding. White blood cell scintigraphy in these eight patients showed a pattern of multlfocal and/or regional bowel activity that changed in intensity and location from early (3–5-hour) to delayed (18–28-hour) images, in contrast, 5 of the 6 patients with documented pseudomembranous colitis (PMC) showed intense WBC localization involving most of the colon. In 3 of these 5 patients, early and delayed images were acquired and showed a relatively constant pattern of WBC localization. The sixth PMC patient had been treated with vancomycin before leukocyte scintigraphy and showed minimal distal small bowel activity on early images and only mild regional colonic activity on delayed images. As in the patients with gastrointestinal bleeding, the remaining six patients showed either focal or regional activity of variable intensity that changed over time. In critically III patients, gastrointestinal bleeding and PMC accounted for 14 of the 20 patients in which labeled leukocyte scintigraphy exhibited colonic activity. A pattern of diffuse, Intense colonic radiotracer activity which persists from early to delayed imaging strongly suggests the presence of PMC in this patient population. Diagnostic tests to confirm the presence of Clostridium difficile should be undertaken in critically III patients in whom leukocyte scintigraphy shows diffuse WBC localization involving most of the colon.
Gene transfer to the rodent placenta in situ. A new strategy for delivering gene products to the fetus.
Authors: M C Senut, S T Suhr, F H Gage
Journal: Journal of Clinical Investigation (1998)

The delivery of biologically active factors to the developing mammalian embryo by in utero gene transfer has generated considerable interest but limited success. The chorioallantoic placenta is a potential alternative target for providing therapeutic transgenes to the fetus during gestation. We demonstrate that somatic gene transfer to the midgestation rat placenta may be efficiently accomplished in situ through the implantation of a variety of genetically modified cells with different antigenic and growth properties. Ex vivo-modified cells survived and retained transgene expression until term. Proteins secreted from the transplanted cells were detectable within the fetal trunk blood. These studies suggest that gene transfer to the placenta may be a useful tool for answering questions of both embryonic and placental development and providing therapeutic proteins during gestation for amelioration of diseases with onset during embryonic life.
Update on endocarditis-associated glomerulonephritis
Authors: Christie L. Boils, Samih H. Nasr, Patrick D. Walker, William G. Couser, Christopher P. Larsen
Journal: Kidney International (2015)

Glomerulonephritis (GN) due to infective endocarditis (IE) is well documented, but most available data are based on old autopsy series. To update information, we now present the largest biopsy-based clinicopathologic series on IE-associated GN. The study group included 49 patients (male-to-female ratio of 3.5:1) with a mean age of 48 years. The most common presenting feature was acute kidney injury. Over half of the patients had no known prior cardiac abnormality. However, the most common comorbidities were cardiac valve disease (30%), intravenous drug use (29%), hepatitis C (20%), and diabetes (18%). The cardiac valve infected was tricuspid in 43%, mitral in 33%, and aortic in 29% of patients. The two most common infective bacteria were Staphylococcus (53%) and Streptococcus (23%). Hypocomplementemia was found in 56% of patients tested and ANCA antibody in 28%. The most common biopsy finding was necrotizing and crescentic GN (53%), followed by endocapillary proliferative GN (37%). C3 deposition was prominent in all cases, whereas IgG deposition was seen in <30% of cases. Most patients had immune deposits detectable by electron microscopy. Thus, IE-associated GN most commonly presents with AKI and complicates staphylococcal tricuspid valve infection. Contrary to infection-associated glomerulonephritis in general, the most common pattern of glomerular injury in IE-associated glomerulonephritis was necrotizing and crescentic glomerulonephritis.
THE RÔLE OF THE ADRENAL CORTEX IN ACUTE ANOXIA 12
Authors: Roger A. Lewis, George W. Thorn, George F. Koepf, Samuel S. Dorrance
Journal: Journal of Clinical Investigation (1942)

We were led to investigate this phase of adrenal cortical function by Evans' observation (1, 2) that liver glycogen and blood glucose increased strik- ingly in rats exposed to low atmospheric pressure.Evans' studies clearly indicated that the phenom- enon did not occur in the absence of the adrenal cortex.However, treatment with adrenal cortical hormone preparations which were then available did not restore to normal the response of adrenal- ectomized animals.Recently Armstrong and Heim (3) reported that hypertrophy of the ad- renals occurred in rabbits which were exposed repeatedly to low atmospheric pressure.Furthermore, it has been suggested that the asthenia and hypotension which have been noted in aviators who have served continuously as pilots bear a resemblance to the clinical syndrome associated with adrenal cortical insufficiency (4).In this investigation rats, rabbits, dogs, mon- keys and human subjects have been exposed for single periods of 1.5 to 24 hours to mixtures of oxygen and nitrogen with the partial pressure of oxygen adjusted to correspond to altitudes of 11,000 to 34,000 feet (Table I).Exposure of TABLE I Altitude equivalent of oxygen-nitrogen mixtures used in these experiments Oxygen concentration per cent of dry gas 20.9 13.8 12.8 10.5 7.1 5.2 Partial pressure of oxygen mm. of Hg 159 105 98 80 54 39 Altitude above sea level feet 0
West Suffolk General Hospital
Authors: J. W. Goodwin
Journal: BMJ (1862)

gical results are entirely different; for, while the capillaries of the kidneys refuse to grant an unchallenged and free transit to blood charged with cuta- neous emcreta, and produce, as a result, Malpighian engorgement, serous transudation, or even the escape of blood, they do not ordinarily offer a similar impe- diment to blood charged with bile.We know, as a clinical fact, that jaundice may exist for years, and
Cognitive Function and Age at Repair of Transposition of the Great Arteries in Children
Authors: Jane W. Newburger, Annette R. Silbert, Lucy P. Buckley, Donald C. Fyler
Journal: New England Journal of Medicine (1984)

To assess the effect of the duration of chronic hypoxemia on cognitive function, we studied 38 children with d-transposition of the great arteries and an intact ventricular septum who underwent corrective surgery at six months to six years of age (median, 1.6 years). Tests included the Wechsler Preschool and Primary Scale of Intelligence (WPPSI) in 33 children and the visual-association and auditory-association subtests of the Illinois Test of Psycholinguistic Abilities in 38 and 37 children, respectively. When controlled for social index, age at repair was inversely associated with the WPPSI intelligence-quotient score (P less than 0.01), the visual-association subtest score (P less than 0.01), and the auditory-association subtest score (P less than 0.1). In contrast, age at repair correlated poorly with cognitive function in children with ventricular septal defect, an acyanotic congenital heart defect. These data suggest that postponing repair of a cyanotic congenital heart disease, such as transposition of the great arteries, is associated with progressive impairment of cognitive function.
"Mama's Boy" Syndrome
Authors: AMAN U. KHAN
Journal: American Journal of Psychiatry (1971)

The author traces the dependent mother-child interaction that develops during the child's infancy and results in a critical social deficit for the child. Most of the 13 children studied did not improve with outpatient therapy but did benefit from short-term hospitalization. The author concludes that hospitalization of children with a mild symbiotic relationship and a great deal of ego differentiation is helpful in bringing about further growth and other social changes in their personal structures.
Life After Medicine
Authors: Alma Denny
Journal: JAMA (1984)

"Tell them to call me if they need me," he says to me. He sits in his apartment above his former office. He knows that the waiting room is full and that his former partners are busy and behind schedule. He is a retired physician, not by choice but because of ill health and disability. He fumed and stormed at being forced by his partners and his family to stop seeing patients, to stop hanging around the hospital, to stop being a doctor! I am his closest friend. It pains me to see a man who thought he could be a doctor forever and made no plans for any other activities to fill a period of retirement. Is there life after practicing medicine? He would roar aloud, "No!" I thought at first that there would be many interesting things he could still do. His stamp collection? "No. I'll let my
Liver transplantation for neonatal hepatitis as compared to the other two leading indications for liver transplantation in children
Authors: F. Adrian Casavilla, Jorge Reyes, Andreas Tzakis, Harlan I. Wright, Judith S. Gavaler, Javier Lendoire, Robert Gordon, Thomas E. Starzl, David H. Van Thiel
Journal: Journal of Hepatology (1994)
Electroencephalography in Hospital and General Consulting Practice: An Introduction
Authors: Jerome K. Merlis
Journal: JAMA (1964)

This volume, written in German, was published simultaneously in English translation. There are no introductory remarks by the author to indicate his objectives, but a preface (by H. Fischgold, a prominent French electroencephalographer), and the title suggest that the aim was to provide an introduction to EEG for specialists in non-neurological fields as well as for neurologists. This is a formidable problem in a field so technically complex and the author has achieved only partial success. There is a considerable amount of useful information, particularly in the brief sections called "Problem Formulation," which summarize the questions which might be answered by the EEG in various clinical situations. However, what is of value is largely buried and almost lost in the unnecessary detail with which the book abounds. This is exemplified by the more than 400 references to the literature, many of which are concerned with relatively minor points or details.
Gates Foundation gives $10bn for research and delivery of vaccines
Authors: A. Gulland
Journal: BMJ (2010)

The Bill & Melinda Gates Foundation has made a new gift of $10bn (£6.3bn; €7.2bn) to help research and develop vaccines and deliver them to developing countries.

Speaking at a press conference at the World Economic Forum in Davos, Switzerland, last week, Mr Gates said that great advances had been made since the Global Alliance for Vaccines and Immunisations (GAVI) was set up 10 years ago.

“The success of both increasing vaccine coverage and getting new vaccines out has been phenomenal. At this milestone we are redoubling our commitment,” said Mr Gates.

Since GAVI …
The World's Banker: A Story of Failed States, Financial Crises, and the Wealth and Poverty of Nations
Authors: Barbara Stocking
Journal: BMJ (2005)

E ven before I was asked to review this book I knew I would have to read it, as the World Bank probably has more influence, for good or ill, on poverty and development than any other institution in the world. Understanding how it has worked in the last 10 years under its controversial leader is very important. I didn't expect to enjoy the book, so I was pleasantly surprised: it was gripping. Sebastian Mallaby Yale University Press, £19.95, pp 462 ISBN 0 300 10801 X http://www.yalebooks.co.uk/ Rating:![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> When James Wolfensohn arrived at the bank in 1995 it was at a dangerous moment in its history. Robert MacNamara's earlier vision of poverty reduction had faded, and the bank had become cautious, technocratic, and out of touch with the effects of its policies on poverty. It was under severe challenge from non-governmental organisations (NGOs), including my own, Oxfam, because its structural adjustment policies were making poor people poorer by reducing public services such as health and education, as well as taking away support to poor farmers. As a result of the rise in oil prices and the decline in income from other commodities, many poor countries had also built up enormous debt, and NGOs were calling for debt relief—although this was ignored by the bank. Wolfensohn was up … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Suppressing T cell motility induced by anti–CTLA-4 monotherapy improves antitumor effects
Authors: Maria Grazia Ruocco, Karsten A. Pilones, Noriko Kawashima, Michael Cammer, Julie Huang, James S. Babb, Mengling Liu, Silvia C. Formenti, Michael L. Dustin, Sandra Demaria
Journal: Journal of Clinical Investigation (2012)

A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance, such as cytotoxic T lymphocyte-associated protein 4 (CTLA-4). However, the determinants of response to anti-CTLA-4 mAb treatment remain incompletely understood. In murine models, anti-CTLA-4 mAbs alone fail to induce effective immune responses to poorly immunogenic tumors but are successful when combined with additional interventions, including local ionizing radiation (IR) therapy. We employed an established model based on control of a mouse carcinoma cell line to study endogenous tumor-infiltrating CD8+ T lymphocytes (TILs) following treatment with the anti-CTLA-4 mAb 9H10. Alone, 9H10 monotherapy reversed the arrest of TILs with carcinoma cells in vivo. In contrast, the combination of 9H10 and IR restored MHC class I-dependent arrest. After implantation, the carcinoma cells had reduced expression of retinoic acid early inducible-1 (RAE-1), a ligand for natural killer cell group 2D (NKG2D) receptor. We found that RAE-1 expression was induced by IR in vivo and that anti-NKG2D mAb blocked the TIL arrest induced by IR/9H10 combination therapy. These results demonstrate that anti-CTLA-4 mAb therapy induces motility of TIL and that NKG2D ligation offsets this effect to enhance TILs arrest and antitumor activity.
COMPARATIVE EFFECTIVENESS OF CORONARY CT ANGIOGRAPHY VERSUS STRESS TESTING USING HIGH-EFFICIENCY SPECT MYOCARDIAL PERFUSION IMAGING AND STRESS-ONLY IMAGING IN THE EMERGENCY DEPARTMENT
Authors: Milena Henzlova, John Savino, Elliot J. Levine, Lori Croft, Andrew Einstein, Luke Hermann, William Duvall
Journal: Journal of the American College of Cardiology (2013)
Die transurethrale Behandlung des Prostata-Adenoms durch Kombination von Elektroresektion (TUR) und Kältechirurgie
Authors: P. Rouvalis
Journal: Endoscopy (1972)

The drawbacks of simple blind cryosurgery made it necessary to seek new ways of improving the procedure. In the first place, the septic complications cryonecrosis within the bladder have to be precluded. The combination of TUR and cryosurgery in the same session proved to be benefical, as each procedure complets the other.