Acute Non-Lymphoblastic Leukemia After Treatment of Nodular Lymphoma with Human Leukocyte Interferon
Authors: RAYMOND P. WARRELL
Journal: Annals of Internal Medicine (1983)

Brief Reports1 April 1983Acute Non-Lymphoblastic Leukemia After Treatment of Nodular Lymphoma with Human Leukocyte InterferonRAYMOND P. WARRELL Jr., M.D., SUSAN E. KROWN, M.D., BENJAMIN KOZINER, M.D., MICHAEL ANDREEFF, M.D., SANFORD J. KEMPIN, M.D.RAYMOND P. WARRELL Jr., M.D.Search for more papers by this author, SUSAN E. KROWN, M.D.Search for more papers by this author, BENJAMIN KOZINER, M.D.Search for more papers by this author, MICHAEL ANDREEFF, M.D.Search for more papers by this author, SANFORD J. KEMPIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-4-482 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere has been an increase in the incidence of acute non-lymphoblastic leukemia after the use of radiation or cytotoxic chemotherapy in patients with malignant lymphoma. However, the subsequent occurrence of this disease in patients with nodular lymphocytic lymphoma who have never received radiation or chemotherapy has not been reported previously. We report a case of acute non-lymphoblastic leukemia which has occurred in a patient with nodular lymphoma whose only previous treatment had consisted of leukocyte interferon.A 57-year-old man developed diffuse lymphadenopathy in September 1979. An excisional biopsy showed a malignant lymphoma of the nodular poorly differentiated lymphocytic type. A...References1 KAPADIA S and KAPLAN S. Simultaneous occurrence of non-Hodgkin's lymphoma and acute myelomonocytic leukemia. Cancer. 1976;38:2557-60. CrossrefMedlineGoogle Scholar2 ROSENBERG S, DIAMOND H, JASLOWITZ B, and CRAVER L. Lymphosarcoma: a review of 1269 cases. Medicine. 1961;40:31-84. CrossrefMedlineGoogle Scholar3 MOERTEL C and HAGEDORN A. Leukemia or lymphoma and coexistent primary malignant lesions: a review of the literature and a study of 120 cases. Blood. 1957;12:788-803. CrossrefMedlineGoogle Scholar4 ZARRABI M. Association of non-Hodgkin's lymphoma and second neoplasms. Semin Oncol. 1980;7:340-51. MedlineGoogle Scholar5 CADMAN E, CAPIZZI R, and BERTINO J. Acute nonlymphocytic leukemia: a delayed complication of Hodgkin's disease therapy. Cancer. 1977;40:1280-96. CrossrefMedlineGoogle Scholar6 BORDEN E and BALL L. Interferons: biochemical, cell growth, inhibitory and immunological effects. In: BROWN EB, ed. Progress in Hematology. New York: Grune and Stratton; 1981: 299-339. Google Scholar7 VERMA D, SPITZER G, GUTTERMAN J, ZANDER A, MCCREDIE K, and DICKE K. Human leukocyte interferon preparation blocks granulopoietic differentiation. Blood. 1979;54:1423-7. CrossrefMedlineGoogle Scholar8 GALLIEN-LARTIGUE O, CARREZ D, DE MAEYER E, and DE MAEYER-GUIGNARD J. Strain dependence of the antiproliferative action of interferon on murine erythroid precursors. Science. 1980;290:292-3. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RAYMOND P. WARRELLJr., M.D.; SUSAN E. KROWN, M.D.; BENJAMIN KOZINER, M.D.; MICHAEL ANDREEFF, M.D.; SANFORD J. KEMPIN, M.D.Affiliations: Memorial Sloan Kettering Cancer Center Cornell University Medical College New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliographyHuman interferon alpha in malignant lymphoma and Hodgkin's disease. Results of the american cancer society trial 1 April 1983Volume 98, Issue 4 Page: 482-483 Keywords Acute myeloid leukemia Biopsy Chemotherapy Cytogenetics Cytotoxic chemotherapy Fellowships Interferons Lymphoma Precursor cells ePublished: 1 December 2008 Issue Published: 1 April 1983 PDF downloadLoading ...