tbuckley/cabot-search huggingface dataset:
Elements That Contribute to Healthy Building Design
Authors: Vivian Loftness, Bert Hakkinen, Olaf Adan, Aino Nevalainen
Journal: Environmental Health Perspectives (2007)

The elements that contribute to a healthy building are multifactorial and can be discussed from different perspectives.WE PRESENT THREE VIEWPOINTS OF DESIGNING A HEALTHY BUILDING: the importance of sustainable development, the role of occupants for ensuring indoor air quality, and ongoing developments related to indoor finishes with low chemical emissions and good fungal resistance.Sustainable design rediscovers the social, environmental, and technical values of pedestrian and mixed-use communities, using existing infrastructures including "main streets" and small-town planning principles and recapturing indoor-outdoor relationships. This type of design introduces nonpolluting materials and assemblies with lower energy requirements and higher durability and recyclability. Building occupants play a major role in maintaining healthy indoor environments, especially in residences. Contributors to indoor air quality include cleaning habits and other behaviors; consumer products, furnishings, and appliances purchases, as well as where and how the occupants use them. Certification of consumer products and building materials as low-emitting products is a primary control measure for achieving good indoor air quality. Key products in this respect are office furniture, flooring, paints and coatings, adhesives and sealants, wall coverings, wood products, textiles, insulation, and cleaning products. Finishing materials play a major role in the quality of indoor air as related to moisture retention and mold growth.Sustainable design emphasizes the needs of infrastructure, lower energy consumption, durability, and recyclability. To ensure good indoor air quality, the product development for household use should aim to reduce material susceptibility to contaminants such as mold and should adopt consumer-oriented product labeling.
1118 POSTTRANSCRIPTIONAL REGULATION OF THE SODIUM TAUROCHOLATE COTRANSPORTING POLYPEPTIDE (NTCP) BY ENDOCYTOSIS AND SUBSEQUENT LYSOSOMAL DEGRADATION
Authors: C. Stross, K. Weissenberger, A. Helmer, B. Görg, D. Häussinger, R. Kubitz
Journal: Journal of Hepatology (2010)
Relationship between Fc receptors, antigen-binding sites on T and B cells, and H-2 complex-associated determinants.
Authors: A Basten, J F Miller, R Abraham
Journal: The Journal of Experimental Medicine (1975)

The relationship between H-2 complex-associated determinants, Fc receptors, and specific antigen-recognition sites on T and B cells was examined by binding and functional assays. The Fc receptor was detected by radiolabeled immune complexes or aggregated human IgG. Both these reagents selectively bound to B cells, not to T cells. When spleen cells, from mice primed to several antigens, were exposed to highly substituted radioactive aggregates, their capacity to transfer both a direct and indirect plaque-forming cell response to these antigens was abrogated. Addition of B cells, but not of T cells, restored responsiveness. Complexed Ig binding to Fc receptors was prevented by pretreatment of mixed lymphoid cell populations with antisera directed against membrane components on the same cell (e.g., H-2) and on other cells (e.g., theta). The lack of specificity of inhibition was thought to be due to the formation on cell surfaces of antigen-antibody complexes which would then attach to the Fc receptor during the incubation precedure. Specific blockade of the Fc receptor during the incubation procedure. Specific blockade of the Fc receptor however occurred when B cells were pretreated with the Fab fragments of anti-H-2 antibody. This was demonstrated autoradiographically and by inhibition of aggregate-induced suicide. The blocking activity of ante-H-2 Fab was removed by absorption with spleen cells from thymectomized irradiated mice but not with thymus cells of appropriate specificity. This suggested that the antibodies involved had specificity for determinants on the B-cell membrane distinct from those coded by the K or D end of the H-2 complex, and either absent from, or poorly represented on, thymus cells. Specific antigen-induced suicide of B cells was achieved simply by incubating the cells with radioactive antigen in the cold. T-cell suicide on the other hand required that the 125I-labeled antigen be presented to the T cells at 37 degrees-C on the surface of spleen cells from antigen-primed mice. Pretreatment of T cells with the Fab fragment of anti-H-2 antibody protected them from the suicide effect. By contrast no such protection of B cells could be achieved by this procedure. In other words H-2 (? Ir)-associated determinants may not only be in close proximity to the antigen-binding site on T cells but, in addition, may be involved in the effective operation of the receptor.
Does This Patient Have Temporal Arteritis?
Authors: Gerald W. Smetana
Journal: JAMA (2002)

Clinicians must be able to confidently diagnose temporal arteritis (TA), since failure to make a correct diagnosis may lead to irreversible visual loss as well as inappropriate evaluation and treatment of headache, fatigue, and other potential presenting symptoms. The diagnostic value of particular signs and symptoms among patients with suspected TA is unknown.To determine the accuracy of historical features, physical examination, and erythrocyte sedimentation rate (ESR) in diagnosis of TA.We performed a MEDLINE search of English-language articles published between January 1966 and July 2000 and a hand search of bibliographies of retrieved articles, previous reviews, monographs, and textbooks.Studies that provided detailed clinical information on patients who had been referred for temporal artery biopsy. Of 114 studies retrieved, 41 met our inclusion criteria; 21 included both biopsy-positive and biopsy-negative patients and formed the core of our review.Both authors independently reviewed each study to determine eligibility, abstracted data using a standardized instrument, and classified study quality using predetermined criteria.The prevalence of TA in the general population is less than 1%. However, in our 21 core studies, 39% of patients referred for temporal artery biopsy had positive results. The only 2 historical features that substantially increased the likelihood of TA among patients referred for biopsy were jaw claudication (positive likelihood ratio [LR], 4.2; 95% confidence interval [CI], 2.8-6.2) and diplopia (positive LR, 3.4; 95% CI, 1.3-8.6). The absence of any temporal artery abnormality was the only clinical factor that modestly reduced the likelihood of disease (negative LR, 0.53; 95% CI, 0.38-0.75). Predictive physical findings included temporal artery beading (positive LR, 4.6; 95% CI, 1.1-18.4), prominence (positive LR, 4.3; 95% CI, 2.1-8.9), and tenderness (positive LR, 2.6; 95% CI, 1.9-3.7). Normal ESR values indicated much less likelihood of disease (negative LR for abnormal ESR, 0.2; 95% CI, 0.08-0.51).A small number of clinical features are helpful in predicting the likelihood of a positive temporal artery biopsy among patients with a clinical suspicion of disease; the most useful finding is a normal ESR, which makes TA unlikely.
Gentamicin nephrotoxicity in extrahepatic cholestasis: Modulation by dietary calcium
Authors: Nimish Vakil, Ali Abu-Alfa, Salim K. Mujais
Journal: Hepatology (1989)

The present study was designed to test the hypothesis that the presence of a specific hepatobiliary disease, namely common bile duct obstruction, in the absence of other risk factors will exacerbate gentamicin nephrotoxicity. Furthermore, since bile duct ligation decreases urinary calcium excretion, we studied the role of calcium supplementation in the prevention of gentamicin nephrotoxicity in this model. Male Sprague-Dawley rats were allocated to sham groups and common bile duct ligation groups. Gentamicin at 40 and 100 mg per kg per day for 5 days induced a more severe azotemia in common bile duct ligation animals than in sham controls. Furthermore, higher levels of renal gentamicin were found in common bile duct ligation rats than in sham rats early in the course of therapy, at its termination and during the recovery period. Pretreatment of common bile duct ligation animals with dietary calcium supplementation significantly attenuated gentamicin nephrotoxicity and the increased renal gentamicin accumulation, whereas initiation of calcium supplementation concurrent with gentamicin administration had no salutary effect. We conclude that experimental extrahepatic cholestasis in the rat, in the absence of any other factor, potentiates gentamicin nephrotoxicity. The effect is prevented by pretreatment with dietary calcium supplementation but is not modified by concurrent administration of a high-calcium diet.
Space and the parietal cortex
Authors: Masud Husain, Parashkev Nachev
Journal: Trends in Cognitive Sciences (2006)

Current views of the parietal cortex have difficulty accommodating the human inferior parietal lobe (IPL) within a simple dorsal versus ventral stream dichotomy. In humans, lesions of the right IPL often lead to syndromes such as hemispatial neglect that are seemingly in accord with the proposal that this region has a crucial role in spatial processing. However, recent imaging and lesion studies have revealed that inferior parietal regions have non-spatial functions, such as in sustaining attention, detecting salient events embedded in a sequence of events and controlling attention over time. Here, we review these findings and show that spatial processes and the visual guidance of action are only part of the repertoire of parietal functions. Although sub-regions in the human superior parietal lobe and intraparietal sulcus contribute to vision-for-action and spatial functions, more inferior parietal regions have distinctly non-spatial attributes that are neither conventionally 'dorsal' nor conventionally 'ventral' in nature. Current views of the parietal cortex have difficulty accommodating the human inferior parietal lobe (IPL) within a simple dorsal versus ventral stream dichotomy. In humans, lesions of the right IPL often lead to syndromes such as hemispatial neglect that are seemingly in accord with the proposal that this region has a crucial role in spatial processing. However, recent imaging and lesion studies have revealed that inferior parietal regions have non-spatial functions, such as in sustaining attention, detecting salient events embedded in a sequence of events and controlling attention over time. Here, we review these findings and show that spatial processes and the visual guidance of action are only part of the repertoire of parietal functions. Although sub-regions in the human superior parietal lobe and intraparietal sulcus contribute to vision-for-action and spatial functions, more inferior parietal regions have distinctly non-spatial attributes that are neither conventionally 'dorsal' nor conventionally 'ventral' in nature.
Multiple Cases of Leukemia Associated With One House
Authors: Peter McPhedran
Journal: JAMA (1969)

Leukemia occurred in four persons associated with a single house in a small town between 1950 and 1967. Three of these persons had acute leukemia and one had chronic granulocytic leukemia progressing to acute leukemia. Three were occupants of the house and the fourth was a frequent visitor. No other occupants of the house have suffered from malignant neoplasm. Radiation surveys of the house and its surroundings revealed no abnormalities. Other town residents with leukemia did not live near the index house and were not clustered in other houses. A survey of 917 cases of leukemia in metropolitan Atlanta revealed only four addresses shared by more than one person with leukemia. All four were addresses of multiple family dwellings. The occurrence of multiple cases of leukemia in a single house is clearly a rare event. While at present their significance is hard to assess, the possible importance of such events warrants their close investigation whenever they are detected.
CHRONIC RECURRENT DISLOCATION OF THE PATELLA
Authors: WALLACE H. COLE
Journal: JAMA (1934)

Dislocations of the patella, both acute and chronic, have been known in medical writings since the earliest times, and from the time of Hippocrates to the present a rather large literature on the subject has been built up. Various classifications have been used in describing the condition, but probably the simple division into (1) acute traumatic dislocation, (2) congenital dislocation and (3) chronic recurrent dislocation seems to clarify the various types as well as any other system. Acute primary dislocations due to severe injury are not within the scope of this paper except for the fact that such a lesion may be the actual cause and fore-runner of a recurrent condition. As such it is well to remember that treatment must be prolonged and made analogous to that of a dislocated shoulder, in which recurrence also is to be feared. Congenital dislocation, from the standpoint of classification, probably should be
Composite Cell Sheets
Authors: Alain Bel, Valérie Planat-Bernard, Atsuhiro Saito, Lionel Bonnevie, Valérie Bellamy, Laurent Sabbah, Linda Bellabas, Benjamin Brinon, Valérie Vanneaux, Pascal Pradeau, Séverine Peyrard, Jérôme Larghero, Julia Pouly, Patrice Binder, Sylvie Garcia, Tatsuya Shimizu, Yoshiki Sawa, Teruo Okano, Patrick Bruneval, Michel Desnos, Albert A. Hagège, Louis Casteilla, Michel Pucéat, Philippe Menasché
Journal: Circulation (2010)

Background— The safety and efficacy of myocardial regeneration using embryonic stem cells are limited by the risk of teratoma and the high rate of cell death. Methods and Results— To address these issues, we developed a composite construct made of a sheet of adipose tissue–derived stroma cells and embryonic stem cell–derived cardiac progenitors. Ten Rhesus monkeys underwent a transient coronary artery occlusion followed, 2 weeks later, by the open-chest delivery of the composite cell sheet over the infarcted area or a sham operation. The sheet was made of adipose tissue–derived stroma cells grown from a biopsy of autologous adipose tissue and cultured onto temperature-responsive dishes. Allogeneic Rhesus embryonic stem cells were committed to a cardiac lineage and immunomagnetically sorted to yield SSEA-1 + cardiac progenitors, which were then deposited onto the cell sheet. Cyclosporine was given for 2 months until the animals were euthanized. Preimplantation studies showed that the SSEA-1 + progenitors expressed cardiac markers and had lost pluripotency. After 2 months, there was no teratoma in any of the 5 cell-treated monkeys. Analysis of &gt;1500 histological sections showed that the SSEA-1 + cardiac progenitors had differentiated into cardiomyocytes, as evidenced by immunofluorescence and real-time polymerase chain reaction. There were also a robust engraftment of autologous adipose tissue–derived stroma cells and increased angiogenesis compared with the sham animals. Conclusions— These data collected in a clinically relevant nonhuman primate model show that developmentally restricted SSEA-1 + cardiac progenitors appear to be safe and highlight the benefit of the epicardial delivery of a construct harboring cells with a cardiomyogenic differentiation potential and cells providing them the necessary trophic support.
Clinical and Pathologic Impact of Select Chromatin-modulating Tumor Suppressors in Clear Cell Renal Cell Carcinoma
Authors: A. Ari Hakimi, Ying Bei Chen, James Michael Wren, Mithat Gonen, Omar Abdel-Wahab, Adriana Heguy, Han Liu, Shugaku Takeda, Satish K. Tickoo, Victor E. Reuter, Martin H. Voss, Robert J. Motzer, Jonathan A. Coleman, Emily H. Cheng, Paul Russo, James J. Hsieh
Journal: European Urology (2012)
Hyperparathyroidism Coexisting With Hypertension and Prolonged Thiazide Administration
Authors: Edward Paloyan
Journal: JAMA (1969)

Hyperparathyroidism associated with prolonged intake of thiazides for essential hypertension has been found in six patients. Although these patients exhibited hypercalcemia, hypophosphatemia, and pathological changes in their parathyroid glands, they did not have the common complications of hyperparathyroidism, such as renal lithiasis, bone resorption, and peptic ulcers. Correction of the disease produced marked subjective improvement in the majority of the patients but failed to influence their hypertension. It is important to determine serum calcium and phosphorus levels in hypertensive patients prior to and during the administration of thiazides.
Points from Letters: Fascioliasis
Authors: A. T. Hunt
Journal: BMJ (1970)

The patient, a widow aged 63, developed a marked bilateral conjunctivitis in July 1970.When questioned, she stated that she had noticed a stinging sensation of the eyes when- ever she tipped a new brand of washing powder into water.This powder, which she had used for a few weeks only, proved to be a well known enzyme detergent.On giving up the use of the preparation the conjunctival signs disappeared and have not returned.Presumably the act of tipping out the washing powder can give rise to a sufficient concentration of enzyme dust to affect the conjunctiva of a sensitive person.When dealing with an unexplained case of allergic conjunctivitis, therefore, it seems worth asking whether the patient has been using a new brand of washing powder.-Iam, etc.,
Transhepatic Cardiac Catheterization in Children
Authors: David Shim, Thomas R. Lloyd, Kyung J. Cho, Catherine P. Moorehead, Robert H. Beekman
Journal: Circulation (1995)

Background In some children with congenital heart disease, conventional venous access is unavailable for cardiac catheterization. This study investigates a novel transhepatic venous approach to cardiac catheterization in children and evaluates its efficacy and safety. Methods and Results Percutaneous transhepatic puncture was performed using a 22-gauge Chiba needle under fluoroscopic guidance. After wire exchanges were performed, a 5F to 8F sheath was positioned in the low right atrium and cardiac catheterization was performed. On completion of the catheterization, the sheath was withdrawn and a 3-mm steel coil was placed in the parenchymal tract between the hepatic vein and liver capsule. Liver enzyme studies were obtained before and after transhepatic catheterization, and an abdominal ultrasound was performed to evaluate the liver 24 hours after the procedure. Percutaneous transhepatic cardiac catheterization was performed successfully in 17 of 18 children in whom it was attempted. Patient age was 30±8 months (mean±SEM; range, 1 day to 9 years), weight was 10.5±1.5 kg (3.1 to 27.5 kg), and mean right atrial pressure was 10±1 mm Hg (5 to 19 mm Hg). Time from initial needle puncture to right atrial entry was 6.2±1.2 minutes. Diagnostic catheterization was performed successfully in all 17 children, and additional interventional procedures were performed in 5 children. The total catheterization time was 2.0±0.2 hours. Serum aspartate aminotransferase increased from 57±15 to 78±8 IU/L ( P =.06), but alanine aminotransferase and gamma-glutamyl transpeptidase did not change. Ultrasound was performed 24 hours after transhepatic catheterization, and no evidence was found in any patient of hemorrhage or subcapsular hematoma. Conclusions These data suggest that this novel transhepatic approach provides an effective and safe route for diagnostic and interventional cardiac catheterization in children.
Meeting Highlights: Symposium on the Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy
Authors: Y. M. Rustum, P. J. Creaven
Journal: JNCI Journal of the National Cancer Institute (1988)

Recent advances in the development of concepts in the laboratory and their application and verification in the clinic were discussed.On the first day of the meeting, the presentations focused on the identification of determinants of response to 5-fluorouracil (5-FU) in combination with folinic acid (FA); particular emphasis was placed on thymidylate synthase as the critical site of action of 5-FU when used in combination with FA.On the second day, the present status of the clinical application of this combination of 5-FU and FA was discussed.This discussion centered primarily on results obtained with this combination in the treatment of carcinomas of the colon and the breast; however, the efficacy of this combination in the treatment of other types of cancer, such as gastric carcinoma, pancreatic carcinoma, and carcinoma of the head and neck, was also discussed.
Psychiatry as a Clinical Neuroscience Discipline
Authors: Thomas R. Insel
Journal: JAMA (2005)

One of the fundamental insights emerging from contemporary neuroscience is that mental illnesses are brain disorders. In contrast to classic neurological illnesses that involve discrete brain lesions, mental disorders need to be addressed as disorders of distributed brain systems with symptoms forged by developmental and social experiences. While genomics will be important for revealing risk, and cellular neuroscience should provide targets for novel treatments for these disorders, it is most likely that the tools of systems neuroscience will yield the biomarkers needed to revolutionize psychiatric diagnosis and treatment. This essay considers the discoveries that will be necessary over the next two decades to translate the promise of modern neuroscience into strategies for prevention and cures of mental disorders. To deliver on this spectacular new potential, clinical neuroscience must be integrated into the discipline of psychiatry, thereby transforming current psychiatric training, tools, and practices.
Abstract 998: Downregulation of survivin suppresses uPA through transcription factor JunB
Authors: Kyung Hee Lee, Sung Ae Koh, Ha Young Lee, Min Kyoung Kim, Kyeong Ok Kim, Se Young Lee, Byung Ik Jang, Se Won Kim, Sang Woon Kim, Sun Kyo Song, Jae-Ryong Kim
Journal: Cancer Research (2011)

Abstract Background: Survivin, identified member of the inhibitor apoptosis protein family, is expressed during development and in various human cancers. However, lts role of clinical relevance in cancers are sill debated. Purpose: We investigated the role of HGF induced activation of a transcription factor JunB, in the expression of survivin and uPA. Methods and Results: Genes induced by HGF were screened by using cDNA microarray technology in stomach cancer cell lines, NUGC3 and MKN28. Expression level of surviving and JunB was further confirmed by read time RT-RCR and western blot analysis. Roles of JunB and survivin in the levels of HGF induced up-regulation of uPA were measured by knock down of survivin with survivin siRNA and chromatic immuno- precipitation assay. The levels of JunB, survivin and uPA were up regulated in cells treated with HGF in a dose dependent manner. HGH-induced up regulations of JunB, surviving, and uPA were inhibited by the pretreatment with an MEK inhibitor, PD 098559. HGH-induced up-regulation of uPA were repressed by survivin knockdown. HGF enhanced the binding activity of JunB to the enhanced the binding activity of JunB to the survivin promoter in control cells, but not in the JunB-sh RNA cells. Transfection with survivin-sh RNA results in decrement of cell proliferation as determined with MTT assays. In an in vitro invasion assay, significantly fewer cells transfected with survivin sh-RNA than control cells were able to invade across a matrigel membrane barrier.Conclusion: Survivin might play an important role in the up-regulation of uPA induced by HGF via JunB and contribute to HGF-mediated tumor invasion and metastasis, which might be promising target for stomach cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 998. doi:10.1158/1538-7445.AM2011-998