tbuckley/cabot-search huggingface dataset:
Newborn With Unexpected Skin Lesions
Authors: Lia Oliveira, Isabel Castro Esteves, Filipa Prata, Cristina Tapadinhas, Cristina Guerreiro, José Gonçalo Marques
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
The Kinetocardiogram
Authors: E. E. EDDLEMAN, KATHRYN WILLIS
Journal: Circulation (1953)

The distribution of the various motions of the anterior chest wall during the cardiac cycle has been studied, with particular reference to their magnitude in normal subjects. A few recordings of the posterior chest wall motions are included. Analysis of the type of distribution and localization of certain motions suggest their origin in terms of response of the chest wall to cardiac forces.
Abstract 2771: Clinical outcomes and prognostic factors in 83 patients with pancreatic cancer treated in phase I clinical trials at M.D. Anderson Cancer Center
Authors: Apostolia M. Tsimberidou, Christos Vaklavas, Sijin Wen, David Hong, Jennifer Wheler, Chaan S. Ng, Aung Naing, Cynthia Uehara, Robert Wolff, Razelle Kurzrock
Journal: Cancer Research (2010)

Abstract Introduction. The outcomes of patients with pancreatic cancer treated on early-phase clinical trials have not been systematically analyzed. The purpose of this study was to report the presenting characteristics and outcomes of patients with locally advanced or metastatic pancreatic cancer treated on phase I clinical trials at a single institution. Patients and Methods. We reviewed the records of consecutive patients with metastatic pancreatic cancer who were treated in the Phase I Clinical Trials Program at The University of Texas M. D. Anderson Cancer Center from November 2004 to March 2009. Data recorded and analyzed included survival, response, and disease characteristics. Results. Eighty-three patients were identified. The median age was 62 years (range, 39-81). There were 40 men and 43 women. The most common metastatic sites were liver (54% of patients), lung (51%), lymph nodes (37%), and peritoneum and omentum (24%). The median number of prior therapies was 2 (range, 0-7). Thirty-two (39%) patients had a history of pancreatectomy. Sixty-seven (81%) patients had ≥1 comorbidity. Of 78 patients evaluable for response, 2 (3%) had a partial response (PR), and 10 (13%) had stable disease (SD) for ≥4 months. With a median follow-up for survivors of 3.7 months, the median survival from presentation in the Phase I Clinic was 5.0 months (95% CI, 3.3-6.2). The median overall survival from diagnosis was 22.1 months (95% CI, 17.9-26.5). The median time to treatment failure (TTF) was 1.5 months (95% CI, 1.3-1.8). In multivariate analysis, independent factors associated with lower rates of PR or SD were liver metastases (p = 0.001) and PS greater than 0 (p = 0.01) (Table 3). Independent factors associated with shorter survival were liver metastases (p = 0.007), calcium ≤ 8.4 mg/nL (p = 0.015), and elevated serum levels of CEA (&amp;gt;6 ng/mL; p = 0.005). Independent factors associated with shorter TTF were history of smoking (p = 0.009), liver metastases (p = 0.001), serum bilirubin levels &amp;gt;1 mg/dL (p = 0.007), and &amp;gt;1 prior therapy (p = 0.002). Conclusions. The median survival in the current study (5 months) compares favorably to the median survival reported with best supportive care (3 months). Our results suggest that phase I clinical trials offer a reasonable therapeutic approach for patients with advanced pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2771.
Restricted list of National Health Service Drugs?
Authors: N D Olsen
Journal: BMJ (1974)

Routine acute care-for example, geriatric assessment, elective surgery, progressing seriously ill, etc. Low LowFive-day investigation units, rehabilitation, convalescence Moderate Low Day stay units-minor operations, specialized acute investigation, cytotoxic treatment, etc. be distributed more efficiently and hence economically.Various categories may be identified (see table ).This sort of organization fits into a divisional system and is in opera- tion, in part at least, in several hospitals.Districts served by several hospitals could benefit if divisional concepts developed among hospitals.Consultants and registrars could be more energetic in their efforts to complete investigations in outpatients.Good clinic organization, with appropriate paramedical staffing, can probably reduce the burdens on the inpatient departments attributable to diabetes, hypertension, and chronic respiratory disease.Day-stay units, if used properly, can treat many patients at present managed in hospital.Extension of
Loss of Baroreflex Bradycardia in Renal Hypertensive Rabbits
Authors: NATALIE ALEXANDER, MARJORIE DECUIR
Journal: Circulation Research (1966)

The degree of reflex bradycardia elicited by a sudden, brief rise in arterial pressure was used as an index of sino-aortic reflex activity in conscious rabbits with early renal hypertension. Change in heart rate was measured every 6 seconds after injected angiotensin which caused a rise in blood pressure of 15 to 60 mm Hg. Ninety-one tests for reflex bradycardia were made in 30 normal rabbits; 14 of them were tested intermittently during the 1 to 40 day period following unilateral nephrectomy and latex encapsulation of the opposite kidney. A total of 62 tests were made after arterial pressure had risen 10 to 80 mm Hg, average 35, above control values. Average decrease in heart rate was significantly less and frequency of negligible reflex bradycardia was much higher in hypertensives than controls. Individual rabbits showed no tendency for reflex bradycardia to return toward normal magnitude. However, the vasomotor component of the sino-aortic reflex mechanism in renal hypertensive rabbits buffered the pressor response to angiotensin in a normal manner. Resetting of sino-aortic reflex activity under hypertensive conditions is discussed.
Concurrent Alterations in <i>TERT</i>, <i>KDM6A</i>, and the BRCA Pathway in Bladder Cancer
Authors: Michael L. Nickerson, Garrett M. Dancik, Kate M. Im, Michael G. Edwards, Sevilay Turan, Joseph Brown, Christina Ruiz-Rodriguez, Charles Owens, James C. Costello, Guangwu Guo, Shirley X. Tsang, Yingrui Li, Quan Zhou, Zhiming Cai, Lee E. Moore, M. Scott Lucia, Michael Dean, Dan Theodorescu
Journal: Clinical Cancer Research (2014)

Genetic analysis of bladder cancer has revealed a number of frequently altered genes, including frequent alterations of the telomerase (TERT) gene promoter, although few altered genes have been functionally evaluated. Our objective is to characterize alterations observed by exome sequencing and sequencing of the TERT promoter, and to examine the functional relevance of histone lysine (K)-specific demethylase 6A (KDM6A/UTX), a frequently mutated histone demethylase, in bladder cancer.We analyzed bladder cancer samples from 54 U.S. patients by exome and targeted sequencing and confirmed somatic variants using normal tissue from the same patient. We examined the biologic function of KDM6A using in vivo and in vitro assays.We observed frequent somatic alterations in BRCA1 associated protein-1 (BAP1) in 15% of tumors, including deleterious alterations to the deubiquitinase active site and the nuclear localization signal. BAP1 mutations contribute to a high frequency of tumors with breast cancer (BRCA) DNA repair pathway alterations and were significantly associated with papillary histologic features in tumors. BAP1 and KDM6A mutations significantly co-occurred in tumors. Somatic variants altering the TERT promoter were found in 69% of tumors but were not correlated with alterations in other bladder cancer genes. We examined the function of KDM6A, altered in 24% of tumors, and show depletion in human bladder cancer cells, enhanced in vitro proliferation, in vivo tumor growth, and cell migration.This study is the first to identify frequent BAP1 and BRCA pathway alterations in bladder cancer, show TERT promoter alterations are independent of other bladder cancer gene alterations, and show KDM6A loss is a driver of the bladder cancer phenotype.
Murine Retroviral but not Human Cellular Promoters Induce In Vivo Erythroid-specific Deregulation that can be Partially Prevented by Insulators
Authors: Elodie Robert-Richard, Emmanuel Richard, Punam Malik, Cécile Ged, Hubert de Verneuil, François Moreau-Gaudry
Journal: Molecular Therapy (2006)

We are developing lentiviral vectors for gene therapy of red blood cell disorders that co-express a transgene in an erythroid-specific manner and the O(6)-methylguanine-DNA-methyltransferase (MGMT) selective gene in a constitutive way. We report that transduction of murine hematopoietic stem cells (HSCs) with a human phosphoglycerate kinase promoter-based vector at low multiplicity of infection (MOI) does not result in a selective in vivo expansion in the presence of alkylating agents. In contrast, by replacing this cellular promoter with the powerful retroviral-derived myeloproliferative sarcoma virus enhancer, negative control region-deleted, dl587rev primer-binding site substituted promoter, the vector allowed efficient chemoprotection of transduced HSCs at low MOI. However, this promoter interacted with the erythroid HS40/ankyrin enhancer/promoter driving green fluorescent protein, leading to an unexpected loss of erythroid specificity. A partial restoration of tissue-specific expression was obtained by interposition of insulator sequences between the expression units. Alternatively, we found that the strong human cellular elongation factor1-alpha promoter allows similar chemoprotection but without any deregulation of the erythroid-specific promoter in the absence of insulators. These data demonstrate that the level of in vivo deregulation induced by a promoter is not correlated with its transcriptional activity.
Post-thymic T lymphocyte maturation during ontogenesis.
Authors: P F Piguet, C Irle, E Kollatte, P Vassalli
Journal: The Journal of Experimental Medicine (1981)

Peripheral T lymphocytes from newborn (4-6-d-old) mice, isolated from the spleen or lymph nodes, show phenotypic features of immature cortical thymocytes, such as high frequencies of proliferating cells and of peanut lectin-binding cells. These are features of peripheral T cells of recent thymic origin, as shown by in situ labeling of thymocytes and subsequent observation of the migrants to the spleen, which were mainly peanut lectin-binding cells. The function of newborn peripheral T cells was compared, on a per T cell basis, with that of thymocytes and of fully mature peripheral T cells of the adult, using preparations of newborn lymph node cells containing approximately 80% of T lymphocytes. They were strikingly (about 10-fold) less competent than adult T cells in their phytohemagglutinin responsiveness, their capacities to induce a graft vs. host reaction, to proliferate in the mixed lymphocyte reaction, and to help B lymphocytes in a humoral response in vivo and in vitro. In contrast, newborn T lymphocytes were comparable to those of adults in their capacity to generate cytotoxic T lymphocytes. No suppressive effect of newborn T lymphocytes could be demonstrated in several of these assays. These results argue for an asynchronous maturation of two T cell subsets during ontogeny and demonstrate that at least some T lymphocytes leave the thymus as immature T cells resembling cortical thymocytes and further mature at the periphery. Investigation of mice submitted to thymectomy of 5 d of age showed that these incompetent post-thymic T lymphocytes are capable of considerable expansion and maturation in the peripheral lymphoid organs in the absence of a thymic influence.
Mediating specific cell adhesion to low-adhesive diblock copolymers by instant modification with cyclic RGD peptides
Authors: E. Lieb, M. Hacker, J. Tessmar, L.A. Kunz-Schughart, J. Fiedler, C. Dahmen, U. Hersel, H. Kessler, M.B. Schulz, A. Göpferich
Journal: Biomaterials (2004)
Pathogenesis of papilloedema and raised intracranial pressure in Guillain-Barre syndrome.
Authors: A C Reid, I T Draper
Journal: BMJ (1980)

was 0 94 gll, haptoglobins 0-12 g/l, and lactate dehydrogenase 1664 U/1.A methaemalbumin test was positive.Her haemoglobin concentration was 10 8 g/dl but subsequently fell to 5-3 g/dl.Her plasma bilirubin concentration was 26 ,umol/l, (156 mg/100 ml), but other liver function tests remained
IRON CHELATION THERAPY WITH DEFERASIROX (EXJADE®) IN REDUCING CARDIAC SIDEROSIS IN β-THALASSEMIA PATIENTS: 2-YEAR RESULTS FROM THE EPIC CARDIAC SUBSTUDY
Authors: Dudley J. Pennell, John Porter, Domenica Cappellini, Lee Lee Chan, Amal El-Beshlawy, Yesim Aydinok, Hishamshah Ibrahim, Chi-Kong Li, Vip Viprakasit, Mohsen Elalfy, Antonis Kattamis, Gillian Smith, Dany Habr, Gabor Domokos, Bernard Roubert, Ali Taher
Journal: Journal of the American College of Cardiology (2010)
Dialume-Diabinese Disaster
Authors: Freda Lengel Arlow
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Errors in the administration of drugs with similar trade names can be catastrophic.<sup>13</sup>Dangers increase when one of the "twins" is more toxic for the population most likely to take the other drug. The following case illustrates a commonplace risk. <h3>Report of a Case.—</h3> A 58-year-old woman with progressive renal failure was brought to our emergency room in a coma. The family reported that the patient had been alert until one day before admission to the hospital, when she appeared drowsy; on the morning of admission, she was found to be unresponsive. In the emergency room, the patient did not respond to 0.4 mg of intravenous (IV) naloxone hydrochloride (Narcan) but woke up immediately after receiving 50% dextrose IV. Initial laboratory values included a serum creatinine level of 6.9 mg/dL, a serum glucose level of 28 mg/dL, and inappropriately high insulin levels. The patient had no
Fortuitous Detection of Pseudoaneurysm by Three-Phase Bone Scan
Authors: Z Unsal Coskun, Charles E. Stewart, Martin Robinson, Gene Beisert, Frank J. Rivera, Orhan K. ??z
Journal: Clinical Nuclear Medicine (2005)

We report the diagnosis of an unsuspected pseudoaneurysm in the lower extremity when 3-phase bone scan was used to evaluate a presumed malignancy. We confirmed the diagnosis with duplex ultrasonography and angiography. Although the primary diagnostic modality for detection of pseudoaneurysm remains duplex sonography, the nuclear medicine practitioner should be vigilant for characteristic presentation of a pseudoaneurysm on a 3-phase bone scan, an area of increased radiotracer activity on blood-flow and blood-pool images that becomes a photopenic area on delayed images. This also underscores the need to consider benign vascular lesions in the differential diagnosis of abnormal 3-phase bone scans for presumed tumors.
Pressure and Oxygen Content Measurements Distal to Temporary and Permanent Unilateral Occlusion of a Pulmonary Artery in Dogs
Authors: LEON CEDKOWICH
Journal: Circulation Research (1958)

Both pressure and oxygen content of blood in the left pulmonary artery distal to an inflated balloon simulate that observed in the wedged cardiac catheter position. Clamping the ipsilateral pulmonary veins after inflation of the left pulmonary artery balloon, in this or in the reverse order, produces a rise in pressure distal to the balloon that exceeds the resting left pulmonary artery pressure. No corresponding increase in oxygen content of blood sampled distal to the inflated balloon, compared with that in the unoccluded pulmonary artery, could be demonstrated. This contrasts with the flow of arterialised blood that had been sampled after some months of permanent left pulmonary artery occlusion from the same position. The pressures both proximal and distal to the site of permanent occlusion are approximately the same.
The United States Pharmacopeia Its Value to the Professions
Authors: William M. Heller
Journal: JAMA (1970)

The United States Pharmacopeia (USP) is 150 years old this year. Founded by physicians, the USP is now produced by a consortium of the colleges and organizations of medicine and pharmacy. The USP directs its attention only to those drugs whose utility is most fully established, and its decisions are of value to all involved in the teaching and practice of medicine. Standards of pharmaceutical quality set by USP are enforced by the Food and Drug Administration (FDA). Greater involvement by physicians is needed in setting the goals for each drug product for which special bioavailability standards are needed.
Primary Care Procedures
Authors: Michael Shelton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mucosal Healing Predicts Late Outcomes After the First Course of Corticosteroids for Newly Diagnosed Ulcerative Colitis
Authors: Sandro Ardizzone, Andrea Cassinotti, Piergiorgio Duca, Cristina Mazzali, Chiara Penati, Gianpiero Manes, Riccardo Marmo, Alessandro Massari, Paola Molteni, Giovanni Maconi, Gabriele Bianchi Porro
Journal: Clinical Gastroenterology and Hepatology (2011)
The osteoinductive properties of mesoporous silicate coated with osteostatin in a rabbit femur cavity defect model
Authors: Cynthia G. Trejo, Daniel Lozano, Miguel Manzano, Juan C. Doadrio, Antonio J. Salinas, Sonia Dapía, Enrique Gómez-Barrena, María Vallet-Regí, Natalio García-Honduvilla, Julia Buján, Pedro Esbrit
Journal: Biomaterials (2010)
Expanding the Roles of Medical Assistants
Authors: Thomas Bodenheimer, Rachel Willard-Grace, Amireh Ghorob
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
A Population-based Survey of the Prevalence and Types of Glaucoma in Central Iran
Authors: Mohammad Pakravan, Shahin Yazdani, Mohammad-Ali Javadi, Heidar Amini, Zohreh Behroozi, Hossein Ziaei, Marzieh Katibeh, Reza Solaimanizad, Elham Ghahari, Mehdi Yaseri
Journal: Ophthalmology (2013)
Cocaine and the Heart
Authors: Robert A. Kloner, Shereif H. Rezkalla
Journal: New England Journal of Medicine (2003)

Cocaine use has been associated with both acute and chronic cardiovascular diseases. These include acute myocardial infarction, myocardial ischemia (both silent ischemia and ischemia associated with angina), acceleration of the development of atherosclerosis, myocarditis, cardiomyopathy (both dilated and hypertrophic), arrhythmias, hypertension, aortic dissection, and endocarditis. An estimated 25 million Americans have tried cocaine at least once.Cocaine may be administered by smoking, nasal insufflation, or intravenous injection; cardiac events can follow administration by any of these routes. Cocaine is rapidly absorbed through the respiratory tract; smoking cocaine delivers the substance to the circulation within seconds to minutes. After nasal insufflation . . .
Supraventricular Tachycardia as Cause of Cyanotic Syncopal Attacks in Tetralogy of Fallot
Authors: Dennison Young, Francisco Elbl
Journal: New England Journal of Medicine (1971)

IN contrast to the frequent occurrence of paroxysmal supraventricular tachycardia (SVT) or the Wolff-Parkinson-White syndrome (or both) in children with Ebstein's anomaly or with cardiomyopathy,1 2 3 their occurrence with tetralogy of Fallot, either as associated manifestations or as precipitating events for cerebral anoxic attacks, is unusual. Electrocardiographic documentation during cyanotic syncopal attacks in tetralogy of Fallot has also been infrequent. Usually, these patients have shown only a mild sinus tachycardia or heightened P waves.4 In our earlier experiences electrocardiograms recorded during attacks have shown either acute ST-segment depression (Fig. 1) or marked bradycardia (sinus, nodal and atrioventricular dissociation) with high P . . .
Imaging Characteristics of Heterotopic Mesenteric Ossification on FDG PET and Tc-99m Bone SPECT
Authors: Sylvia Deryk, Lode Goethals, Christian Vanhove, Caroline Geers, Frederik Vandenbroucke, Karolien Van Hove, Axel Bossuyt, Tony Lahoutte
Journal: Clinical Nuclear Medicine (2008)

A CT scan of a 69-year-old male patient, performed for staging of suspected lung carcinoma, incidentally showed an irregular lesion of 10 cm in the upper abdomen. Further investigation using FDG-PET showed only moderately increased glucose metabolism, whereas Tc-99m MDP SPECT revealed intense osteoblastic activity inside the lesion. A CT-guided biopsy was performed and histologic analysis established the diagnosis of heterotopic mesenteric ossification. This pathology is rare and mostly diagnosed when it is complicated by small bowel obstruction.