tbuckley/cabot-search huggingface dataset:
Endoscopic and histological findings in the duodenum of adults with celiac disease before and after changing to a gluten-free diet: a 2-year prospective study
Authors: A. Tursi, G. Brandimarte, G. Giorgetti, W. Elisei, C. Inchingolo, E. Monardo, F. Aiello
Journal: Endoscopy (2006)

Published follow-up data on small-intestinal recovery in patients with celiac disease are scarce and contradictory. This is especially the case for adult patients, who often show incomplete histological recovery after starting a gluten-free diet (GFD). We conducted a 2-year prospective study to evaluate the effectiveness of a GFD in improving the endoscopic and histological duodenal findings in adults with celiac disease.We studied 42 consecutive adults with newly diagnosed celiac disease (13 men, 29 women; mean age 32.7 years, range 15 - 72 years). All the patients underwent esophagogastroduodenoscopy and small-bowel biopsy. We devised our own grading system for the endoscopic appearance of the duodenum, which ranged from "normal" appearance to "mild", "moderate", or "severe" alterations. Small-bowel biopsies were obtained from the second part of the duodenum (and from the duodenal bulb when it had a micronodular appearance). The histopathological appearances were described according to modified Marsh criteria.A normal endoscopic appearance in the duodenum was found in 5/42 patients (11.9 %) at entry and in 32/42 patients (76.2 %) after 2 years on a GFD. Subdividing the patients according to age, patients aged from 15 years to 60 years showed significant improvement within 12 months ( P < 0.0001 for patients aged from 15 years to 45 years; P < 0.003 for patients in the 46 years to 60 years group), whereas the improvement in endoscopic findings in patients older than 60 years was not statistically significant, even 24 months after starting the GFD. "Normal" histology was reported in none of the patients at entry, but in 25 patients (59.5 %) after 24 months on a GFD, but this parameter did not show a significant improvement until the patients had been on the GFD for 12 months ( P < 0.0001). Only the younger patients (5 - 30 years) showed significant improvement of histology within 12 months ( P < 0.034); older patients (>30 years) showed histological improvement but this was not statistically significant, even after 24 months on a GFD.This study shows for the first time that endoscopic recovery is faster than histological recovery in adults with celiac disease who go on a GFD. Moreover, older patients showed incomplete endoscopic and histological recovery even 24 months after starting a GFD. We therefore advise, as a minimum recommendation, that follow-up biopsies should be taken 1 - 2 years after starting a GFD in adults with celiac disease.
Practical limitations of epidemiologic methods.
Authors: A M Lilienfeld
Journal: Environmental Health Perspectives (1983)

Epidemiologic methods can be categorized into demographic studies of mortality and morbidity and observational studies that are either retrospective or prospective. Some of the limitations of demographic studies are illustrated by a review of one specific mortality study showing possible relationship of nuclear fallout to leukemia. Problems of accuracy of diagnosis or causes of death on death certificates, estimates of population, migration from areas of study, and the issue of "ecological fallacy" are discussed. Retrospective studies have such problems as recall of previous environmental exposure, selection bias and survivor bias. In environmental epidemiology, prospective studies have been used. The problems associated with these studies are illustrated by reviewing some of the details of the study of effects of microwave radiation on embassy employees in Moscow. The study population had to be reconstructed, individuals had to be located and information on exposure status had to be obtained by questionnaire. The relatively small size of the exposed group permitted the detection of only fairly large relative risks. Despite these limitations, epidemiologic studies have been remarkably productive in elucidating etiological factors. They are necessary since "the proper study of man is man."
Acute immobilization stress induces clinical and neuroimmunological alterations in experimental murine cutaneous leishmaniasis
Authors: M.R. Ruiz, A.G. Quinones, N.L. Diaz, F.J. Tapia
Journal: British Journal of Dermatology (2003)

Background The skin is an important component of the neuroendocrine‐immune axis. Several studies have shown that stress exacerbates skin disorders, affecting the function of sebaceous glands, keratinocytes, epidermal Langerhans cells and other cells, having an impact on the pathogenesis of many immunologically associated skin diseases. In American cutaneous leishmaniasis, we have shown the importance of the epidermis as a regulatory site, with the key participation of Langerhans cells. Objectives To analyse the effect of acute immobilization stress on Langerhans cells, substance P (SP), calcitonin gene‐related peptide (CGRP) and the natural course of infection in a murine model of cutaneous leishmaniasis. Methods BALB/c mice, susceptible to Leishmania infection, were placed under acute stress by immobilization (confinement) for 2 or 8 h before inoculation with L. mexicana (MHOM/BZ/82/BEL21). An avidin–biotin immunoperoxidase technique was used for cell and neuropeptide identification. Results The stressed animals became more susceptible to the parasite infection, which was manifested by acceleration and exacerbation of the lesions. In addition, the stressed animals showed morphological alterations (spherical bodies and shortened dendrites) and decreased numbers of epidermal Langerhans cells, when compared with control L. mexicana‐infected mice. Mice stressed for 8 h showed greater and antidromic immunoreactivity to CGRP and SP at the time of infection. Moreover, the single inoculation of parasites caused a decrease of CGRP innervation. Conclusions Acute immobilization stress induces an immunosuppressive state that further favours Leishmania invasion in susceptible animals.
Low serum interleukin-2 receptor levels correlate with a good prognosis in patients with Hodgkin's lymphoma
Authors: Angela Gause, Volker Roschansky, Astrid Tschiersch, Kleri Smith, Dirk Hasenclever, Rudolf Schmits, Volker Diehl, Michael Pfreundschuh
Journal: Annals of Oncology (1991)
MURDER AND INSANITY: A SURVEY
Authors: JOHN LANZKRON
Journal: American Journal of Psychiatry (1963)

A statistical evaluation of 150 homicidal patients was presented. The ratio of male: female patients was 4:1. One hundred and fifty-seven persons were killed by 150 patients. Of the victims 73 (47%) involved family members. Thirty-two male patients (27%) killed their wives, whereas 6 wives (19%) killed their husbands. Fifteen men (13%) killed their girlfriends; 7 female patients (22%) killed their boyfriends. fanticide and murder of children amounted to 22 (14%) of the victims (40% of the female murderers killed their infants and/or children). The cases may, grosso modo, be classified as follows(13): 1. Those in which the homicide was the direct offspring of delusions (paranoid group as described in this paper): 40%; 2. Those in which the homicide was committed during a paroxysm of insanity and/or was committed by manifestly insane persons, from motives and conditions which might influence the "sane mind" such as anger, revenge, jealousy, etc. : 32.6%; 3. Those in which the insanity was said to have developed after the homicide which was committed for motives such as robbery (9), morbid jealousy, sex crimes, anger, "cuckolding-reaction," revenge, etc. (psychosis w/psyohopathic personality): 27.3%. In most of the cases classified under Group 1 (40%) forebodings of the malignant nature of patients' mental illness were present over a long period; the malignant nature of persistent delusions of infidelity in the involutional psychosis has been previously described(11). The remaining diagnostic groups (described under 2) usually unfold the symptoms of their mental illness over a long period. Prevention in Group 3 is often more a penal than a psychiatric problem. Intemperate use of alcohol was a contributing factor in 34% of our cases, whereas severe intoxication at the time of the crime could be elicited from the records in 12.5% of the cases. It is suggested that an interdisciplinary team consisting of specialists collaborating with each other in cultural, constitutional, psychological, neurological, genetic and dynamic studies run their data concerning homicidal patients through a computing machine and establish prediction tables for the various mental illnesses which would be used as a yardstick for prevention. I would like to conclude with A. Wikler's(12) definition and goals of psychiatric research: that sort of activity which is directed to the accumulation of data that are useful for the purpose of prediction and control of observable phenomena. The phenomena with which the psychiatrist is concerned are largely those related to the interpersonal activities of human beings. He wishes to be able to predict such behavior and where necessary for the patient, society, or both, to alter it.
Intra-Uterine Myocardial Infarction
Authors: James F. Clapp
Journal: JAMA (1961)

MYOCARDIAL infarction in the newborn is a rare event. Ravich and Rosenblatt reported 2 cases in 1947. 1 Subsequent reports have related such neonatal infarcts to an aberrant origin or other abnormalities of the coronary arteries such as medial calcific sclerosis, focal intimal proliferation, or subintimal fibrosis. 2-6 Most of these coronary lesions presumably develop during fetal life, and yet only one report has appeared of myocardial infarction in utero. 2 The current report records a second case of myocardial infarction in utero. The coronary arterial lesion proved of particular interest because of its similarity to lesions sometimes seen in adult coronary arterial disease.  Report of a Case  A 24-year-old, RH negative, gravida 2, para 1, white female was delivered of a 7 lb., 10 oz. (3,458.6 gm.) female following a pregnancy complicated only by a 36-lb. (18 kg.) weight gain. Labor was oxytocin (Pitocin) induced and lasted 4½ hours.
The Therapeutic Value of the Hypophosphites (Iron, Soda, Lime, and Magnesia) Combined Soluble Tonic for Children, etc
Authors: F. Churchill
Journal: BMJ (1880)

cember 13th, on intra-uterine -medication, makes -an observation -which induces -me to send a short description of an instrument which, for some years, I have fotmd very useful in overenming the inconverience to which he allades,-namely, that, in te--introuction of the probe armed with cotton-wool soaked in carbolic acid or other fluid, muth of that fluid is wiped off before' the-inftument reaches the part upon which it is desi-ed to act.To atvoid tbis, I -at first used an ordinary flexible catheter with a piece cut off its-extremity, but this was not well suited for repeated use.I therefore requested Mr. Young (Edinburgh) to make this instrument for me, -which is a modification of the late Sir Jamnes Simpson's-2porte-caustique.It is. a silver caniula, eleven inches long, of the calibre of a No. 6 catheter, -bent at an obtuse angle three inches frqm its extremity, and having-a knob on its convexcity two-inches and three-quarters from its -extremity like that on an uterine sound.It has a .stilettetwo inches and a half longer, the -projecting portion slightly roughened, terminating in a round knob, which, when-the stilette is-dlrawn in, closes theend of the cannula, failitating its-introduction , and confining the fluid with which the cotton-wool -on the stilette is soaked.The stilette has also a sort of-wedge-shaped collar, two inches and a half from its extremity, to enable it to bedrawn back into the canntsla before the instrument is-withdrawn from the uterus.The wool should not be wrapped-on the stilette too tightly ;-and in drawing the stilette-with the soaked wool into the cannula, it showh Idbe-guide in-withthe4finger-s, so as not to allow wool and fluid -to be -scraped off on the end--of the
Response to Letter Regarding Article, “Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention: The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial”
Authors: Borja Ibanez, Carlos Macaya, Vicente Sánchez-Brunete, Gonzalo Pizarro, Leticia Fernández-Friera, Alonso Mateos, Antonio Fernández-Ortiz, José M. García-Ruiz, Ana García-Álvarez, Andrés Iñiguez, Jesús Jiménez-Borreguero, Pedro López-Romero, Rodrigo Fernández-Jiménez, Javier Goicolea, Borja Ruiz-Mateos, Teresa Bastante, Mercedes Arias, José A. Iglesias-Vázquez, Maite D. Rodriguez, Noemí Escalera, Carlos Acebal, José A. Cabrera, Juan Valenciano, Armando Pérez de Prado, María J. Fernández-Campos, Isabel Casado, Juan C. García-Rubira, Jaime García-Prieto, David Sanz-Rosa, Carlos Cuellas, Rosana Hernández-Antolín, Agustín Albarrán, Felipe Fernández-Vázquez, José M. de la Torre-Hernández, Stuart Pocock, Ginés Sanz, Valentin Fuster
Journal: Circulation (2014)
Dapsone and severe hypoalbuminaemia in dermatitis herpetiformis
Authors: R. E. COWAN, J. T. WRIGHT
Journal: British Journal of Dermatology (1981)

A case of severe hypoalbuminaemia in a patient on long-term dapsone treatment for dermatitis herpetiformis is described. The mechanism for this complication is uncertain, but increased intravascular albumin catabolism has been suggested.
Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog Mll5
Authors: Vikas Madan, Babita Madan, Urszula Brykczynska, Frédéric Zilbermann, Kevin Hogeveen, Konstanze Döhner, Hartmut Döhner, Odile Weber, Carmen Blum, Hans-Reimer Rodewald, Paolo Sassone-Corsi, Antoine H. F. M. Peters, Hans Jörg Fehling
Journal: Blood (2008)
Eheberatung als Gruppenarbeit
Authors: Rosmarie Janner, J. Janner
Journal: Psychotherapy and Psychosomatics (1966)

Research Articles| February 11 2010 Eheberatung als Gruppenarbeit Subject Area: Psychiatry and Psychology Rosmarie Janner; Rosmarie Janner Psychiatrische Universitätspoliklinik für Erwachsene, Basel (Direktor: Prof. Dr. P. Kielholz) Search for other works by this author on: This Site PubMed Google Scholar J. Janner J. Janner Psychiatrische Universitätspoliklinik für Erwachsene, Basel (Direktor: Prof. Dr. P. Kielholz) Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1966) 14 (1): 17–31. https://doi.org/10.1159/000285809 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Rosmarie Janner, J. Janner; Eheberatung als Gruppenarbeit. Psychother Psychosom 1 January 1966; 14 (1): 17–31. https://doi.org/10.1159/000285809 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1966Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Subclinical Thyroid Disease
Authors: Nananda F. Col, Martin I. Surks, Gilbert H. Daniels
Journal: JAMA (2004)

Subclinical hypothyroidism and hyperthyroidism are diagnoses based on laboratory evaluation with few if any clinical signs or symptoms. Subclinical hypothyroidism is defined as an elevation in serum thyroid-stimulating hormone (TSH) above the upper limit of the reference range (0.45-4.5 mIU/L) with normal serum FT4 concentration; subclinical hyperthyroidism is defined as a decrease in serum TSH below the reference range with normal serum FT4 and T3 concentrations. Though these conditions represent the earliest stages of thyroid dysfunction, the benefits of detecting and treating subclinical thyroid disease are not well established. Most persons found to have subclinical thyroid disease will have TSH values between 0.1 and 0.45 mIU/L or between 4.5 and 10 mIU/L, for which the benefits of treatment are not clearly established; treatment may be beneficial in individuals with serum TSH lower than 0.1 mIU/L or higher than 10 mIU/L. This article illustrates approaches to managing patients with subclinical hypothyroidism and hyperthyroidism through 5 case scenarios that apply the principles of evidence-based medicine. Because of the substantial uncertainty concerning the consequences of untreated subclinical hypothyroidism and hyperthyroidism, as well as the benefit of initiating treatment, patient preferences are important in deciding on management of subclinical disease.
Bronchoalveolar lavage via a modified stomach tube in intubated patients with the acquired immunodeficiency syndrome and diffuse pneumonia.
Authors: R Minutoli, E Eden, C Brachfeld
Journal: Thorax (1990)

A simple non-bronchoscopic bronchoalveolar lavage method was used in 30 patients with the acquired immunodeficiency syndrome undergoing assisted ventilation for respiratory failure. A modified Argyle Levin stomach tube was passed via the endotracheal tube and lavage performed. The lavage was well tolerated and performed quickly and easily, required little training, and had a high degree of sensitivity (73%--a diagnosis in 22 of the 30 cases).
Varicella–Zoster Vaccine for the Prevention of Herpes Zoster
Authors: David W. Kimberlin, Richard J. Whitley
Journal: New England Journal of Medicine (2007)

A 64-year-old man in good general health presents to his internist for a routine examination. In a large clinical trial, the varicella–zoster vaccine reduced the incidence of herpes zoster by 51% and the incidence of postherpetic neuralgia by 67%. Should he receive this vaccine?
B7-H4 Is a Novel Membrane-Bound Protein and a Candidate Serum and Tissue Biomarker for Ovarian Cancer
Authors: Iris Simon, Shaoqiu Zhuo, Laura Corral, Eleftherios P. Diamandis, Mark J. Sarno, Robert L. Wolfert, Nam W. Kim
Journal: Cancer Research (2006)

Using cDNA database mining strategies and real-time quantitative reverse transcription-PCR, we identified B7-H4 as a novel gene that is overexpressed in ovarian and breast cancer tissues when compared with normal tissues. The gene encodes a protein of 282 amino acids with a signal sequence, an immunoglobulin domain, and a COOH-terminal hydrophobic transmembrane domain. Immunohistochemistry experiments show plasma membrane staining in serous ovarian and breast cancer, confirming the tissue specificity and cell surface localization. We have developed a sensitive dual monoclonal antibody sandwich ELISA to analyze the level of B7-H4 protein in >2,500 serum samples, ascites fluids, and tissue lysates. High levels of B7-H4 protein were detected in ovarian cancer tissue lysates when compared with normal tissues. B7-H4 was present at low levels in all sera but showed an elevated level in serum samples from ovarian cancer patients when compared with healthy controls or women with benign gynecologic diseases. The median B7-H4 concentration in endometrioid and serous histotypes was higher than in mucinous histotypes, consistent with results of immunohistochemical staining. The multivariate logistic regression analysis of B7-H4 and CA125 measured in the same sample set resulted in an area under the curve (AUC) of 0.86 for all stages and 0.86 for stage I/II patients, which was significantly higher than the AUC for either marker alone. In early-stage patients, the sensitivity at 97% specificity increased from 52% for CA125 alone to 65% when used in combination with B7-H4. We conclude that B7-H4 is a promising new biomarker for ovarian carcinoma.
Low dose intravenous 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) for the treatment of Paget's disease of bone.
Authors: J A Cantrill, H M Buckler, D C Anderson
Journal: Annals of the Rheumatic Diseases (1986)

Twenty patients with severe symptomatic Paget's disease were treated with a series of 15 mg intravenous infusions of 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD). A regimen of either five consecutive days of treatment (regimen 1) or a course of 12 weekly infusions was administered (regimen 2). In five cases regimen 2 followed regimen 1 after a three month interval. Alkaline phosphatase levels fell in all patients and returned to the normal range in 12. All but one of the patients obtained symptomatic improvement. There was a median fall in alkaline phosphatase activity of 63%. Eight patients observed a transient increase in bone pain starting about 24 hours after the first infusion. Intravenous APD was well tolerated, and we conclude that it is an effective treatment for Paget's disease; this route of administration avoids the problem of poor and unpredictable gastrointestinal absorption seen when a bisphosphonate is given orally. The optimal dose and duration of APD therapy, frequency of relapse, requirement for further courses, and merits relative to other second generation bisphosphonates remain to be established.
Mark Twain and "The Doctor" in Innocents Abroad.
Authors: Wm. Allen Pusey
Journal: JAMA (1901)

Chicago, April 23, 1901. <h3>To the Editor:</h3> —Every little while there appears a statement in one of our medical journals concerning some doctor who is or was—for this statement usually appears in an obituary notice "the original of Mark Twain's doctor in 'Innocents Abroad.' " There is, accordingly, a possibility that the original doctor of "Innocents Abroad" may become as numerous as the original Uncle Tom of Mrs. Stowe's famous novel. I have no doubt that these statements are all made in good faith; the explanation doubtless being that the particular person of whom the statement is made has been such a jovial, clever good fellow that he might have been the original of Mark Twain's doctor even if he is not. and so the tradition had gradually grown up around him. In order to settle the question I wrote to Mr. S. L. Clemens (Mark Twain) a few days ago