Increased Synovial Interleukin-8 and Interleukin-6 Levels in Pseudogout Associated with Granulocyte Colony-Stimulating Factor
Authors: Shinji Teramoto
Journal: Annals of Internal Medicine (1998)

Letters1 September 1998Increased Synovial Interleukin-8 and Interleukin-6 Levels in Pseudogout Associated with Granulocyte Colony-Stimulating FactorShinji Teramoto, MD, Hiroshi Yamamoto, MD, and Yasuyoshi Ouchi, MDShinji Teramoto, MDTokyo University Hospital; Tokyo, 113 JapanSearch for more papers by this author, Hiroshi Yamamoto, MDTokyo University Hospital; Tokyo, 113 JapanSearch for more papers by this author, and Yasuyoshi Ouchi, MDTokyo University Hospital; Tokyo, 113 JapanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-5-199809010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although granulocyte colony-stimulating factor (GCSF) substantially shortens the period of severe neutropenia that follows high-dose chemotherapy, several side effects, including bone pain, were noted in patients given GCSF [1]. Furthermore, Sandor and colleagues [2] recently suggested that pseudogout can be caused by GCSF. Because GCSF can provoke the other proinflammatory cytokines, GCSF-induced cytokines may affect pseudogout in joints. However, no evidence is available on the direct involvement of GCSF-related cytokines in pseudogout. We report a case of pseudogout after GCSF treatment in which synovial levels of GCSF, interleukin (IL)-8, and IL-6 were markedly increased.An 83-year-old woman ...References1. Gudi R, Pachter BR. Astemizole in the treatment of granulocyte colony-stimulating factor-induced bone pain. Ann Intern Med. 1996; 123:236-7. Google Scholar2. Sandor V, Hassan R, Kohn E. Exacerbation of pseudogout by granulocyte colony-stimulating factor. Ann Intern Med. 1996; 125:781. Google Scholar3. Miller EJ, Brelsford WG. Interleukin-8: the major neutrophil chemotoxin in a case of pseudogout. J Rheumatol. 1994; 20:1250-2. Google Scholar4. Hachicha M, Naccache PH, McColl SR. Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis. J Exp Med. 1995; 182:2019-25. Google Scholar Author, Article, and Disclosure InformationAffiliations: Tokyo University Hospital; Tokyo, 113 Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPseudogout Attack after Pegfilgrastim Administration in Anaplastic Large Cell LymphomaPossible causes of acute pseudogout in older patients with osteoarthritisClinical trials review: Crystal deposition diseasesDrugs acting on the immune system 1 September 1998Volume 129, Issue 5Page: 424-425KeywordsArthralgiaCalciumCytokinesGranulocyte colony stimulating factorGranulocytesKnee jointsNeutropeniaNeutrophilsRenal failureSynovial fluid Issue Published: 1 September 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...