Myasthenia Gravis and Auto-immune Disease
Authors: THOMAS E. PIEMME
Journal: Annals of Internal Medicine (1964)

Case Studies1 January 1964Myasthenia Gravis and Auto-immune DiseaseReview of the Literature Including a Case Report of the Coexistence of Myasthenia and Systemic Lupus ErythematosusTHOMAS E. PIEMME, M.D.THOMAS E. PIEMME, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-1-130 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent immunologic studies, combined with an increasing awareness of some of the more unusual features of classical myasthenia gravis, have led writers to question whether this disease might not be a further example of the expanding group of hyperimmune diseases. The evidence for this concept, first advanced by Simpson (1), has been recently reviewed by Harvey and Johns (2), and by Osserman (3).The above hypothesis is enhanced by the frequent occurrence of myasthenia, or myasthenic syndromes, with known auto-immune diseases, or with entities that have, or may have, immunologic implications. The association of myasthenia with tumors of the thymus,...References1. SIMPSON JA: Myasthenia gravis: a new hypothesis. Scottish Med. J. 5: 419, 1960. CrossrefGoogle Scholar2. HARVEYJOHNS AMRJ: Myasthenia gravis and the thymus. (Editorial) Amer. J. Med. 31: 1, 1962. CrossrefGoogle Scholar3. OSSERMAN KE: Myasthenia gravis: an auto-immune mechanism? Bull. Sch. Med. Univ. Maryland 47: 12, 1961. Google Scholar4. CASTLEMANNORRIS BEH: The pathology of the thymus in myasthenia gravis. Medicine 28: 27, 1949. CrossrefMedlineGoogle Scholar5. ROWLANDHOEFERARANOW LPPFH: Myasthenic syndromes. Res. Publ. Ass. Nerv. Ment. Dis. 38: 548, 1958. Google Scholar6. 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CrossrefGoogle Scholar18. METCALF D: The thymic origin of the plasma lymphocytosis-stimulating factor. Brit. J. Cancer 10: 442, 1956. CrossrefMedlineGoogle Scholar19. BURNETMACKAY FMIR: Lymphoepithelial structures and auto-immune disease. Lancet 2: 1030, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Departments of Medicine, West Roxbury Veterans Administration Hospital and Harvard Medical School, Boston, Massachusetts.Requests for reprints should be addressed to Thomas E. Piemme, M.D., Presbyterian-University Hospital, Pittsburgh 13, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFighting rheumatoid arthritis: Kv1.3 as a therapeutic targetPemphigus associated diseases and induced pemphigusThe neuro-ophthalmology of systemic lupus erythematosusArthritis in myasthenia gravis.Treatment of ocular myasthenia with corticotrophin3) 最近みられた興味ある症例Die Pathogenese der Myasthenia gravis als immunologisches ProblemThree-year observation of a myasthenic syndrome concurrent with other autoimmune syndromes in a patient with thymomaPSEUDOMYASTHENIC SYNDROME IN SYSTEMIC LUPUS ERYTHEMATOSUSNEUROTOXIC SIDE-EFFECTS OF PIPERAZINEAssociation of Trimethadione Therapy and Myasthenia GravisAUTOIMMUNITY?GENERAL CONCEPTSMYASTHENIA AS AN AUTOIMMUNE DISEASE: CLINICAL ASPECTSImmunpathologische Begleiterkrankungen und -phänomene des Lupus erythematodesÜber die motorischen Endplattenerkrankungen unter besonderer Berücksichtigung der Myasthenia GravisStudies in Myasthenia GravisAutoantibodies and Disease 1 January 1964Volume 60, Issue 1Page: 130-135KeywordsAntigensAutoimmune diseasesHospital medicineMyasthenia gravisThymus Issue Published: 1 January 1964 PDF DownloadLoading ...