tbuckley/cabot-search huggingface dataset:
X-linked lymphoproliferative syndrome presenting with systemic lymphocytic vasculitis
Authors: Hirokazu Kanegane, Yoshikiyo Ito, Koichi Ohshima, Takeshi Shichijo, Kunio Tomimasu, Keiko Nomura, Takeshi Futatani, Ryo Sumazaki, Toshio Miyawaki
Journal: American Journal of Hematology (2005)

X-linked lymphoproliferative syndrome (XLP) is a rare, often fatal, primary immunodeficiency disease characterized by an abnormal response to Epstein-Barr virus (EBV) infection. The gene responsible for XLP has been identified as SH2D1A/DSHP/SLAM-associated protein (SAP). The major clinical manifestations include fulminant infectious mononucleosis, lymphoproliferative disorder, and dysgammaglobulinemia. Affected males uncommonly present with lymphocytic vasculitis in addition to aplastic anemia. In this study, we describe a Japanese XLP patient who presented with hypogammaglobulinemia following acute EBV-induced infectious mononucleosis in the infancy and later had systemic lymphocytic vasculitis and hemophagocytic lymphohistiocytosis in the adulthood, which resolved by steroid pulse therapy. The patient's SAP gene was found to harbor a missense mutation (His8Asp), presumably resulting in defective expression of SAP in T cells. Biopsy specimens of lung and skin disclosed that CD8+ T cells predominantly infiltrated vascular vessels. However, immunohistochemical examination showed that EBV-infected cells were not identifiable in the vessels. We propose that T-cell-mediated immune dysregulation in XLP can cause vasculitis by EBV infection-unrelated mechanism. Am. J. Hematol. 78:130–133, 2005. © 2005 Wiley-Liss, Inc.
Application of Visante Optical Coherence Tomography Tear Meniscus Height Measurement in the Diagnosis of Dry Eye Disease
Authors: Osama M.A. Ibrahim, Murat Dogru, Yoji Takano, Yoshiyuki Satake, Tais Hitomi Wakamatsu, Kazumi Fukagawa, Kazuo Tsubota, Hiroshi Fujishima
Journal: Ophthalmology (2010)
NK‐cell related neoplasms in Osaka, Japan
Authors: Hajime Miyazato, Shin‐ichi Nakatsuka, Zhiming Dong, Tetsuya Takakuwa, Kazumasa Oka, Hitoshi Hanamoto, Yoichi Tatsumi, Akihisa Kanamaru, Katsuyuki Aozasa
Journal: American Journal of Hematology (2004)

Abstract The frequency of NK‐cell related neoplasms was estimated among lymphoproliferative diseases diagnosed and treated in Osaka, Japan, from 1999 to 2003. The total number of registered cases was 1,400, among which 1,092 patients were diagnosed as having malignant lymphomas. There were 987 cases of non‐Hodgkin's lymphoma (NHL) and 105 (9.6%) of Hodgkin's lymphoma. Immunophenotypic analysis revealed that 743 patients had B‐cell lymphomas and 209 T/NK‐cell lymphomas. Among the T/NK‐cell lymphomas, 40 showed positive immunoreactivity for CD56, and thus they were judged to be NK/T‐cell lymphomas. They included one blastic NK‐cell lymphoma and 39 NK/T‐cell lymphomas. NK/T‐cell lymphomas were further divided into three categories based on the main site of lesions: nasal type (23 cases), non‐nasal extranodal type (11 cases), and nodal type (5 cases). The positive rate of infection with the Epstein‐Barr virus determined by in situ hybridization was 83%, 36%, and 25% in the nasal, non‐nasal, and nodal type, respectively. A mosquito allergy was found in one patient with EBV‐positive non‐nasal NK/T‐cell lymphoma. The present study showed that the frequency of NK‐cell related neoplasms among all NHLs was 4% in an ATL‐non‐endemic area of Japan. Am. J. Hematol 76:230–235, 2004. © 2004 Wiley‐Liss, Inc.
ARTERIAL WALL REMODELING IN ASSOCIATION WITH ABDOMINAL OBESITY, ADIPOCYTOKINES AND PROGRESSION OF CORONARY ATHEROSCLEROSIS: INSIGHTS FROM THE STRADIVARIUS STUDY
Authors: Kiyoko Uno, Stephen J. Nicholls, Jean-Pierre Després, Mingyuan Shao, Tingfei Hu, Paul Schoenhagen, Ozgur Bayturan, Andrea J. Lavoie, Ajai Shreevatsa, Samir Kapadia, Venu Menon, Christophe Gaudin, Bernard Job, E. Murat Tuzcu, Steven E. Nissen
Journal: Journal of the American College of Cardiology (2010)
ON THE UNITY OF DIPHTHERIA AND MEMBRANOUS CROUP.Read in the Section of Laryngology and Otology at the Forty-first Annual Meeting of the American Medical Association, Nashville, Tenn., May, 1890.
Authors: D. BRYSON DELAVAN
Journal: JAMA (1890)

The discussion of this apparently trite and timeworn question would seem out of place at this meeting, were it not that, even at the present day, we are still unable to speak with certainty concerning it. The failure to have secured a more definite conclusion regarding it is in no wise due to lack of care on the part of those who have investigated it. On the contrary, it has engaged the attention of a large number of earnest students; the subject has been studied collectively as well as by individuals, and, finally, the diseases in question are of such common occurrence that abundant material has always been forthcoming upon which deductions could be based. With all this accumulation of material and of effort it would seem strange that sufficient doubt should remain to warrant discussion. We find, however, in studying the differential diagnosis between diphtheria and croup as commonly
Use of #10 Crochet Hook to Retrieve Buried Sutures
Authors: Irving L. Lichtenstein
Journal: JAMA (1965)

To the Editor:—  Since the increased use of nonabsorbable sutures, the not infrequent suture sinus has plagued surgeon and patient alike. These tracts can persist for years with simple serous drainage, at times forming recurring abscesses. The great concern to the patient is that a serious condition, even concer, may be present. The worried patient may convert into a shopper, visiting physician after physician for reassurance. Cure is associated with great relief and gratification. These sinuses will close permanently only when the non-e absorbable suture is removed from the depths of the wound (usually the fascia, but such removal is not easy with conventional instruments).  Twenty years or more ago, one of us (S. H.) first used an ordinary No. 10 crochet hook to clear up this problem. This instrument can be purchased easily for 15¢. Rarely have we failed to snag the offending suture after twisting the hook in
THE RECOGNITION AND TRAINING OF CONGENITAL MENTAL DEFECTIVES
Authors: W. A. Potts
Journal: BMJ (1908)

possibly be due to the viscosity of the blood.-ParkesWeber showed this to be much above the natural in his cases, and the obsetvation has been confirmed.But this could only act by delaying the-flow, and;when, as in my case, the heart is natural, the pulse regular, and the blood pressure at the usual level, it cannot reasonably be sur- posed that the blood is passing the lungs with such diffi- culty as to cause dyspnoea.
Coffee consumption and bladder cancer are linked, analysis shows
Authors: K. Gruber
Journal: BMJ (2015)

A long suspected link between coffee consumption and the development of bladder cancer has been confirmed by a new meta-analysis of 34 case-control and six cohort studies. The link was found to be stronger among males and non-smoking coffee drinkers.

Bladder cancer is a major health problem, being the most common type of cancer of the urinary tract and the ninth most common cancer among men, with nearly 330 000 new cases and 130 000 deaths reported worldwide every year.

Since the 1970s coffee consumption has …
Effect of heat on the circular dichroism of spectrin in hereditary pyropoikilocytosis.
Authors: K Chang, J R Williamson, H S Zarkowsky
Journal: Journal of Clinical Investigation (1979)

Hereditary pyropikilocytosis is a hemolytic anemia in which the erythrocytes show increased sensitivity to heat-induced fragmentation. Circular dichroism measurements were employed to study the effect of heat on the secondary structure of pyropoikilocyte membrane proteins. The magnitude of the ellipticity at 222 nm over the temperature range from 25 degrees to 70 degrees C was determined for erythrocyte ghosts, spectrin, and ghost residue after extraction. In pyropoikilocyte ghosts, protein denaturation began at a lower temperature and the midpoint of the structural transition was displaced from 49 degrees C (the value for normal ghosts) to 44 degrees C. This thermal transition was present in spectrin, but not in the ghost residue after extraction. We conclude that an abnormality in the spectrin molecule alters the physical and morphologic properties of the erythrocyte membrane in pyropoikilocytosis.
New Ultrasound “Elasticity” Technique May Reduce Need for Breast Biopsies
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Weighing up disability
Authors: Kenneth C James, Susan D Foster
Journal: The Lancet (1999)

Is it possible to agree on a universal weighting of disability? T B Üstün and colleagues report in today's Lancet on an effort to discover whether respondents from 14 countries could agree on rankings of disability states. The measure they used was the disability-adjusted life-year (DALY), introduced in the World Bank's 1993 World Development Report Investing in Health?1 World Development Report. Oxford University Press, New York1993: 3-5 Google Scholar On the grounds that any discussion of health policy must begin with an assessment of the size of health problems, the report introduced the DALY as a unit of measure for "the global burden of disease". As predicted in 1993, 2 World Bank's cure for donor fatigue. Lancet. 1993; 342: 63-64 Abstract PubMed Scopus (20) Google Scholar the DALY has proven controversial. Because the measure has programmatic implications and could dictate priorities for action and funding-and, by extension, national health policies— emotions run high. Multiple-informant ranking of the disabling effects of different health conditions in 14 countriesRank order of disabling effects of health conditions is relatively stable across countries, informant groups, and methods. However, the differences are large enough to cast doubt on the assumption of universality of experts' judgments about disability weights. Further studies are needed because disability weights are central to the calculation of disability-adjusted life years. Full-Text PDF
Hepatic Paragonimiasis Revealed by FDG PET/CT
Authors: Wuying Cheng, Fang Li, Hongming Zhuang, Dingrong Zhong, Chenxi Wu, Zhaohui Zhu
Journal: Clinical Nuclear Medicine (2010)

A 72-year-old asymptomatic man with a hepatic lesion incidentally detected by ultrasonography in routine examination undertook fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography for further evaluation. The images revealed increased FDG activity in the lesion, which was suggestive of malignancy. However, the pathologic examination demonstrated that the lesion was a granuloma caused by Paragonimus westermani, a lung fluke. Although increased FDG activity in the lung due to P. westermani infection is expected and reported previously, such lesion identified in the liver by FDG positron emission tomography/computed tomography is unusual.
"Huffer's" Neuropathy
Authors: Leon D. Prockop
Journal: JAMA (1974)

INSULT to the human peripheral nervous system caused by exposure to organic compounds is well known. The epidemic occurrence of triorthocresyl phosphate (TOCP) neuropathy and acrylamide neuropathy are two examples.<sup>1,2</sup>Further, the occurrence of peripheral neuropathy after inhalation of organic solvents has been reported. For example, accidental industrial exposure to n-hexane<sup>3</sup>and methyl butyl ketone<sup>4</sup>has resulted in neuropathy. In addition, deliberate "sniffing" of glue containing n-hexane and toluene has resulted in a predominantly motor neuropathy with severe neurogenic atrophy.<sup>5</sup> We report the occurrence of severe peripheral neuropathy in seven men who repeatedly inhaled a commercially available lacquer thinner for the euphoric sensation, ie, "high," it produces. This inhalation is called "<i>huffing</i>." Because of the general uniformity of clinical onset, progression, and physical findings, these cases are reported as a group. Aspects of individual cases of special neurologic interest will be reported later with the results
Cerebrospinal fluid cytokine levels and dexamethasone therapy in bacterial meningitis
Authors: Shouichi Ohga, Kenji Okada, Kohji Ueda, Hidetoshi Takada, Mitsuhiro Ohta, Tomonobu Aoki, Naoko Kinukawa, Sumio Miyazaki, Toshiro Hara
Journal: Journal of Infection (1999)
Familial Polyposis Coli and Hepatocellular Neoplasms
Authors: H. J.R. Bussey
Journal: Hepatology (1990)

Two cases of hepatocellular carcinoma in patients with familial polyposis coli (FPC) have recently been reported in the literature. Hepatoblastoma was also reported in five children with maternal ancestors with FPC. We report a case of hepatoblastoma in a female infant whose father has FPC as further evidence of an association between hepatoblastoma and FPC.
STUDIES ON THE PHENOMENON OF D'HÉRELLE WITH BACILLUS DYSENTERIÆ
Authors: Martha Wollstein
Journal: The Journal of Experimental Medicine (1921)

It has been shown that a lytic fluid for dysentery bacilli can be obtained from the peritoneum of the guinea pig by intraperitoneal inoculation of live dysentery bacilli, and that the lytic action of such a fluid is not strictly specific, but that it exerts a group action on the dysentery-colon-typhoid group of bacilli. A lytic fluid with similar effects was obtained from a child dying of Flexner dysentery infection, and an anti-colon bacillus lytic fluid from a child who died of intussusception with colon bacillus peritonitis. The action of the lytic fluid on the dysentery bacilli, both in vivo and in vitro, is to divide the culture into sensitive and resistant strains, and the latter can be carried to a degree of very marked, if not complete resistance to lysis. Such resistant strains are not lysogenic, nor are they agglutinable. The sensitive strains are lysogenic and agglutinable. Varying degrees of sensitive and resistant bacilli exist in a single culture. The sensitive bacilli gradually lose the lysogenic property which they acquired under special conditions, but the very resistant bacilli never acquire that property. It is conceivable that the resistant strains are responsible for the untoward outcome of disease in human beings. Theoretically the administration of lytic fluid should rid the intestinal tract of most of the infecting bacilli, and only if completely resistant bacilli in large numbers remain unacted on is the outcome of the disease a fatal one.
Bronchial hyperresponsiveness in atopic dermatitis
Authors: G. M. CORBO, E. FERRANTE, B. MACCIOCCHI, A. FORESI, V. DE ANGELIS, G. FABRIZI, G. CIAPPI
Journal: Allergy (1989)

We investigated the prevalence of bronchial asthma, immediate skin reactivity and bronchial hyperresponsiveness in 40 patients with atopic dermatitis (AD). Eight patients reported to have asthma while 29 were found responders to methacholine test (PC 20 Mch &lt; 64 mg/ml) and 21 were skin reactors. The prevalence of skin positive reactions did not differ in responder and non‐responder (PC 20 Mch &gt; 64 mg/ml) groups. Males were more likely both to have bronchial asthma and be responders to methacholine test than females. Moreover, responders had an earlier age of onset of AD than the non‐responders. We suggest that bronchial responsiveness should be evaluated in children with AD.
Addiction: More than innate rationality
Authors: Daniel H. Lende
Journal: Behavioral and Brain Sciences (2008)

Abstract Redish et al. rely too much on a rational and innate view of decision-making, when their emphasis on variation, their integrative spirit, and their neuroscientific insights point towards a broader view of why addiction is such a tenacious problem. The integration of subjective, sociocultural, and evolutionary factors with cognitive neuroscience advances our understanding of addiction and decision-making.
The Original Pathologische Anatomie Leiden-Endothelium Monoclonal Antibody Recognizes a Vascular Endothelial Growth Factor–Binding Site within Neuropilin-1
Authors: Diana E. Jaalouk, Michael G. Ozawa, Jessica Sun, Johanna Lahdenranta, Reinier O. Schlingemann, Renata Pasqualini, Wadih Arap
Journal: Cancer Research (2007)

Abstract For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial cell marker, has remained elusive. Here, we used a combinatorial phage display–based approach (“epitope mapping”) to select peptides binding to the original PAL-E antibody. We found that a subset of the selected panel of peptides had motifs with strong homology to an exposed site within the b1 domain of human neuropilin-1 (NRP-1). We confirmed peptide binding by ELISA and by surface plasmon resonance. We also showed that the PAL-E antigen colocalizes with NRP-1 staining in endothelial cells. Crystal structure of the b1 domain in NRP-1 suggests that the PAL-E binding site overlaps with a vascular endothelial growth factor (VEGF) binding site. Taken together, these results indicate that NRP-1 is an endothelial cell antigen recognized by the true PAL-E antibody. The consistent biochemical, morphologic, and functional features between the PAL-E antigen and NRP-1 support our interpretation. Given that NRP-1 is a VEGF receptor, these results explain the attributes of the PAL-E antibody as a marker of vascular permeability and angiogenesis. [Cancer Res 2007;67(20):9623–9]
IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells
Authors: Manolis Pasparakis, Marc Schmidt-Supprian, Klaus Rajewsky
Journal: The Journal of Experimental Medicine (2002)

Nuclear factor (NF)-κB proteins play crucial roles in immune responses and cellular survival. Activation of NF-κB is mediated by the IκB kinase (IKK) complex, which is composed of two kinases, IKK1 and IKK2, and a regulatory subunit termed NF-κB essential modulator (NEMO). IKK2- and NEMO-deficient mice die at early embryonic stages. We therefore used conditional gene targeting to evaluate the role of these proteins in B cells in adult mice. B lineage–specific disruption of either IKK signaling by deletion of NEMO, or of IKK2-specific signals by ablation of IKK2 activity leads to the disappearance of mature B lymphocytes. We conclude that maintenance of mature B cells depends on IKK-mediated activation of NF-κB.
Viral Imitations of Host Defense Proteins
Authors: Philip M. Murphy
Journal: JAMA (1994)

<h3>CASE PRESENTATION</h3> A 40-year-old Indian woman with Takayasu's arteritis presented to the National Naval Medical Center with chest pain of 1 day's duration. One year previously, she had presented with malaise, diminished left upper extremity pulses, and an elevated erythrocyte sedimentation rate. A diagnosis of Takayasu's arteritis had been made by angiographic demonstration of stenosis of the left subclavian artery. She had been treated initially with 1 mg/kg per day of prednisone with angiographically evident improvement, and the drug dosage had been tapered over the past year to 10 mg of prednisone every other day. On the day of admission she noted constant, sharp left chest pain without radiation and without dyspnea. Her past medical history was otherwise unremarkable. The physical examination revealed a woman who appeared well nourished. Her temperature was 38.5°C orally. Her heart rate was 92 beats per minute, and her blood pressure was 126/78 mm Hg.
The Nuts and Bolts of Peanut Allergy
Authors: Aidan Long
Journal: New England Journal of Medicine (2002)

In this issue of the Journal, Sampson1 reviews the clinical features of allergy to peanuts. The question is why, in a small but apparently increasing percentage of the population, does the ingestion of a seemingly innocuous and healthful food result in an allergic reaction?The clinical manifestations of an allergic reaction to foods are the end result of an orchestrated series of events involving the immune system that have their origins in a prior exposure to the offending allergen (Figure 1). During the initial exposure, which may occur in utero, during breast-feeding, or in early childhood, antibodies of the IgE . . .
Coffee, Myocardial Infarction, and CYP Nomenclature
Authors: Magnus Ingelman-Sundberg, Sarah C. Sim, Daniel W. Nebert
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patients Who Can't Read
Authors: Steven H Miles, Terry Davis
Journal: JAMA (1995)

Our health care system requires that patients be able to read. The face-to-face words between a patient and physician embellish, reinforce, and personalize a larger framework of knowledge and learning that is transmitted through the written word. Given the increasing complexity of medical knowledge and the costs of medical illiteracy, inadequate literacy skills are an increasing barrier to good health care. In this issue ofThe Journal, Williams et al<sup>1</sup>show that many English-speaking and Spanish-speaking patients do not read well enough to adequately function in health care settings. The authors go beyond comparing reading ability with the difficulty of written health materials to quantitate how illiteracy can interfere with common tasks, such as understanding how to take medication or when the next appointment is scheduled. The study is limited in that it was conducted at only two public teaching hospitals and that it did not compare patients' ability