tbuckley/cabot-search huggingface dataset:
Heart failure services in England improve
Authors: Susan Mayor
Journal: BMJ (2007)

The management of patients with heart failure has generally improved in the past few years, according to a comprehensive review of services provided by the NHS in England. But the review also shows that a substantial number of people with the condition might remain undiagnosed and untreated.

The Healthcare Commission, which monitors the quality of NHS services, assessed the heart failure services provided by 303 primary care trusts and their main hospital providers in 2005-6. Two thirds of these healthcare communities scored “excellent” (28) or “good” (160) for their overall services to heart failure patients, based on confirmation of diagnosis, prescribing and monitoring, access to specialist services and structured care, mortality, and rates of readmission. A further 89 were assessed as “fair.” However, 26 were considered “weak.” These have since been required to …
120-kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A.
Authors: P E Zimmerman, D R Voelker, F X McCormack, J R Paulsrud, W J Martin
Journal: Journal of Clinical Investigation (1992)

Pneumocystis carinii is the most common cause of life-threatening pneumonia in immunocompromised patients. In the current study, surfactant protein A (SP-A), the major nonserum protein constituent of pulmonary surfactant, is demonstrated to bind P. carinii in a specific and saturable manner. SP-A is surface bound and does not appear to be internalized or degraded by the P. carinii organism. Furthermore, SP-A binding to P. carinii is time- and calcium-dependent and is competitively inhibited by mannosyl albumin. In the absence of calcium or the presence of excess mannosyl albumin, SP-A binding to P. carinii is reduced by 95 and 71%, respectively. SP-A avidly binds P. carinii with a Kd of 8 x 10(-9) M and an estimated 8.4 x 10(6) SP-A binding sites per P. carinii organism, as determined from Scatchard plots. SP-A is shown to bind P. carinii in vivo, and a putative binding site for SP-A on P. carinii is demonstrated to be the mannoserich surface membrane glycoprotein gp120. These findings suggest that P. carinii can interact with the phospholipid-rich material in the alveolar spaces by specifically binding a major protein constituent of pulmonary surfactant.
More on Rippers vs Binders
Authors: Victor R. Neufeld, Anne Leibl
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 March 1971More on Rippers vs BindersVICTOR R. NEUFELD, M.D. F.R.C.P.(C), ANNE LEIBL, M.L.S.VICTOR R. NEUFELD, M.D. F.R.C.P.(C)Search for more papers by this author, ANNE LEIBL, M.L.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-3-453_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: As an additional comment on your "Binders vs. Rippers" poll(1), the following may be of interest.We have recently completed a survey (2) of the self-education patterns of interns, residents, and research fellows in 13 Toronto hospitals and compared these with attending staff physicians in a single hospital (Toronto Western Hospital). Included in the data was information on the number of binders and rippers of general and specialty journals.The summary (Table 1) indicates that for specialty journals (of which the ANNALSis one), the ratio of rippers to binders was 2.4 to 1, in comparison with...References1. DEATON J: The Annals: to rip or bind? (Letter). Ann Intern Med 71:212, 1969 LinkGoogle Scholar2. NEUFELDLEIBL VA: Unpublished observations Google Scholar3. Letters: Rip or bind? A ripping response. Ann Intern Med 71:864-867, 1969 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: VICTOR R. NEUFELD, M.D. F.R.C.P.(C); ANNE LEIBL, M.L.S.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1971Volume 74, Issue 3Page: 453-453 ePublished: 1 December 2008 Issue Published: 1 March 1971 PDF downloadLoading ...
The Vascular War
Authors: Victor Gurewich
Journal: JAMA (1989)

<h3>To the Editor.—</h3> The article by Wexler et al entitled "The Vascular War of 1988"<sup>1</sup>and the accompanying commentary by Dr Zarins<sup>2</sup>call attention to an important problem that affects not only certain subspecialty practices, but, more important, patient welfare and medical costs. Wexler et al have made a forthright proposal to resolve the "turf battle" among vascular surgeons, radiologists, and cardiologists competing for rights to perform balloon or laser angioplasty or other new transluminal interventions. Their establishment of a Center for Interventional Vascular Therapies at the Stanford (Calif) University Medical Center should help arbitrate the conflicts. However, it skirts a more profound issue. Beyond the turf battle and who wins it lies the fundamental question of how to establish the indications for these new, appealing, and expensive interventions. This objective may not be met by the competing specialties themselves because of a conflict of interests. In view
Expression of Skp2, a p27Kip1 ubiquitin ligase, in malignant lymphoma: correlation with p27Kip1 and proliferation index
Authors: Megan S. Lim, Ann Adamson, Zhaosheng Lin, Bayardo Perez-Ordonez, Richard C. K. Jordan, Sheryl Tripp, Sherrie L. Perkins, Kojo S. J. Elenitoba-Johnson
Journal: Blood (2002)
Fast atrial fibrillation induced by azathioprine
Authors: G. Nikolic
Journal: BMJ (1985)

It is unlikely that this evidence will be persuasive justification for computerising repeat prescribing.Much more convincing are likely to be the other improvements identified by Dr Roland and col- leagues, in particular better information recorded about repeat prescribing and the opportunities that computers can offer for audit and clinical review.'These, unfortunately, are likely to create work for the doctor, not save it.
New Laser Target: Otitis Media
Authors: Mike Mitka
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NATIONAL MEDICAL SCHOOL.
Authors: ALBERT S. ASHMEAD
Journal: JAMA (1897)

A wolf in sheep's clothing could not be more dangerous to the shepherd's fold than the enemy which confronts the general body of practitioners today. Accumulation of wealth in a few men's hands and the drifting of these men to the cities, is one of the causes which render the endowment of medical schools, the founding of hospitals, easier than ever. The medcal schools will obtain from rich men money to build Smith clinics, Jones maternities, or Robinson hospitals or operating wards. In the expenditure of such funds, the medical man who obtains the superintendence ceases to be independent; he becomes, as a rule, the retainer, if not the sycophant of the rich man. In times of yore a student starting the study of medicine appeared at college, after having read with his preceptor, a general practitioner in the country, for from one to three years. Today preceptorships have ceased
ELEVATED CETP ACTIVITY DURING ACUTE PHASE OF MYOCARDIAL INFARCTION IS INDEPENDENTLY ASSOCIATED WITH NO REFLOW, ENDOTHELIAL DYSFUNCTION, AND ADVERSE CLINICAL OUTCOME
Authors: Luiz S rgio F. Carvalho, Valeria N. Figueiredo, Simone Santos, Rodrigo G P Modolo, Natlia Panzoldo, Vitor W M Virginio, Eliana de Faria, Jose Carlos Q. Silva, Andrei Sposito
Journal: Journal of the American College of Cardiology (2014)
Correlation between cardiac involvement and CTG trinucleotide repeat length in myotonic dystrophy
Authors: Paola Melacini, Carla Villanova, Elisabetta Menegazzo, Giuseppe Novelli, Gianantonio Danieli, Giulio Rizzoli, Giuseppe Fasoli, Corrado Angelini, Gianfranco Buja, Manuela Miorelli, Bruno Dallapiccola, Sergio Dalla Volta
Journal: Journal of the American College of Cardiology (1995)
Health situation in Gaza is “grim,” UN relief chief says
Authors: John Zarocostas
Journal: BMJ (2008)

Health care in the Gaza Strip remains dire, top UN humanitarian officials have warned. Essential drugs, medical supplies and parts, and fuel to power hospital generators are in acute shortage, and travel for patients who are seeking urgent treatment outside the area is restricted.

The same officials have emphasised that the situation could deteriorate further unless Israel eases the restrictions that have curtailed the flow of humanitarian and commercial supplies to meet the needs of the 1.5 million population in Gaza.

The World Health Organization in its latest biannual plan for humanitarian action cautions that chronic situations, such as that in the Palestinian territories occupied by Israel “will continue to deteriorate and will thus require significant resources in 2008-9.”

“I have been shocked by the grim and miserable things that I have seen and heard today, which are the result of current restrictions and the limitations on the number of goods that are being allowed into Gaza,” said Sir John Holmes, the UN emergency relief coordinator during a day long visit to the Gaza Strip.

Sir John, a former ambassador and diplomatic adviser to the former UK prime minister, …
Akinesia and Dyskinesia In Myocardial Infarction
Authors: Albert H. Douglas
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I would like to comment on a recent MEDICAL NEWS report, "Non-contractile Heart Area Excised, Preventing Failure" (<b>204</b>: April 22, 1968, adv p 26), which summarizes a paper presented at a meeting of the American College of Physicians by Falsetti and Schimert. Four cases are described, in which a noncontractile or akinetic zone of myocardium was excised, with survival of two. Akinesia rather than dyskinesia as responsible for cardiac failure in such cases is not necessarily the explanation. Calcified aneurysms of the ventricle, even when huge, are compatible with long survival, without cardiac failure. Figure 1 illustrates such a case in a 77-year-old man, who had the lesion for 17 years. A roentgen kymogram of the same heart, demonstrates absence of pulsation in the calcified aneurysm (Fig 2). Crastnopol et al demonstrated in dogs that Teflon prostheses could replace excised myocardium, with survival for more than a
Cigarette Smoking as a Risk Factor in Stroke
Authors: J. R. Varma
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I wish to refer to the article in the Feb 19 issue of<i>JAMA</i>by Wolf et al<sup>1</sup>concerning the relationship between cigarette smoking and the incidence of stroke. It is not surprising that the study found a significant relationship to stroke after age and hypertension were taken into account. It is further enlightening that smoking continued to be a significant independent factor in stroke and brain infarction after other risk factors were added. The hazards of smoking, the morbidity associated with this vice or habit, and the high mortality related to diseases associated with smoking are a curse to humanity. The amount of personal misery, man-hours lost in productivity, deprivation in family life, economic impact, burden on health care resources, and other hidden factors is far in excess of the revenues generated from tobacco-related industries. Is it not time for physicians to band together—the American
Radioactive dextran particles for studying circulation in animals
Authors: P SVEDMAN, B NOSSLIN, U ROTHMAN
Journal: Cardiovascular Research (1983)

Journal Article Radioactive dextran particles for studying circulation in animals Get access P SVEDMAN, P SVEDMAN § **From the Department of Plastic and Reconstructive Surgery, Allmänna Sjukhuset, S-21401 Malmoe, Sweden §Address for correspondence and reprints: P Svedman, Department of Plastic and Reconstructive Surgery, Allmänna Sjukhuset, S-214 01 Malmoe, Sweden. Search for other works by this author on: Oxford Academic PubMed Google Scholar B NOSSLIN, B NOSSLIN †From the Department of Nuclear Medicine, Allmänna Sjukhuset, S-21401 Malmoe, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar U ROTHMAN U ROTHMAN ‡From the Department of Experimental Surgery, Allmänna Sjukhuset, S-21401 Malmoe, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 17, Issue 11, November 1983, Pages 656–661, https://doi.org/10.1093/cvr/17.11.656 Published: 01 November 1983
Cardiac arrest after treatment with intravenous domperidone.
Authors: J B Roussak, P Carey, H Parry
Journal: BMJ (1984)

Cardiac arrest after treatment with intravenous domperidone Domperidone (Motilium, Janssen Pharmaceuticals) is a widely used antiemetic.We report four cases of cardiac arrest after intravenous administration of this drug. Case reportsCase 1-A 53 year old woman with inoperable ovarian carcinoma was receiving treatment with cisplatinum.Before starting treatment she had been clinically well with normal electrolyte concentrations (potassium 3-7 mmol(mEq)/1; normal 3 4-5 0 mmol/l).She was given domperidone
NEPHROPEXY FOR THE RELIEF OF URETERAL KINKS ASSOCIATED WITH PTOSIS
Authors: C. E. BURFORD
Journal: JAMA (1927)

In presenting this subject i make no claim of new methods, for nephropexy is an old operation first performed by Hahn of Berlin in 1881, and used extensively from fifteen to thirty years ago by Edebohls, Newman, Suckling, 1 Billington, Sir Henry Morris, 2 Glenard, Sir William Roberts, Kelly 3 and others, by various methods and with varied results. In more recent years, little has been written on the subject, and I believe that comparatively few nephropexies are done, although more ptosed kidneys, with ureteral kinks producing distressing symptoms, are being found through the aid of the modern cystoscopic roentgenographic table combination, permitting us to secure easily good pyelograms and ureterograms in both the recumbent and the upright postures as a matter of routine. Feeling that the operation has fallen into undeserved disuse, and encouraged by some excellent results in forty-eight operations, many of the patients having undergone other surgical
An Incentive Plan for National Health Insurance
Authors: Norman Rosenberg
Journal: JAMA (1977)

THERE have been many health insurance and provision plans proposed for adoption on a national basis. Firsthand evaluations also abound for health programs already in effect in other countries. Analyses of these range from the hypercritical to those that extol the virtues of the particular plan under discussion. All investigators, whether on one side of the question or the other, agree that either the adoption of universal insurance coverage or other more drastic implementation of the universal "right to health care" would bring with it an increase in use of the health system. This would exaggerate or create a shortage in personnel and facilities, while at the same time increasing the national health budget. Medical care, especially modern medical care, employing the latest diagnostic and therapeutic technics, gets more expensive every day. A ten-cent warfarin sodium tablet calls for a five-dollar laboratory test for its controlled administration. The research costs
Natural History of Chronic Bronchitis in Working Men.
Authors: Charles M. Fletcher
Journal: Annals of Internal Medicine (1968)

s1 May 1968Natural History of Chronic Bronchitis in Working Men.Charles M. Fletcher, M.D., F.R.C.P., Cecily M. Tinker, M.R.C.P., I. David Hill, B.SC., Frank S. Speizer, M.D.Charles M. Fletcher, M.D., F.R.C.P.Search for more papers by this author, Cecily M. Tinker, M.R.C.P.Search for more papers by this author, I. David Hill, B.SC.Search for more papers by this author, Frank S. Speizer, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1185_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe study was designed to test the hypothesis that in the development of chronic airway obstruction mucous hypersecretion encourages bronchial infection which causes bronchiolar damage, or emphysema, or both. Biennial measurements of sputum volume, respiratory illness frequency, and forced expiratory volume (FEV) were made on 905 working men in West London from 1961 through 1966. Mean sputum volume declined steadily, perhaps owing to reduction in London's air pollution. It declined most steeply in men who stopped smoking. Chest illnesses had little effect. Only one new case of simple bronchitis appeared. Illness frequency increased with increasing sputum volume and decreasing FEV... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1185-1186KeywordsAir pollutionBronchitisChronic bronchitisEmphysemaForced expiratory volumePulmonary diseasesSputumThorax Issue Published: 1 May 1968 PDF DownloadLoading ...
Clinical evaluation of jaundice. A guideline of the Patient Care Committee of the American Gastroenterological Association
Authors: B. B. Frank
Journal: JAMA (1989)

Many diagnostic studies and procedures are available for the evaluation of jaundice. By judicious selection of those that are most likely to lead to a prompt diagnosis and by weighing their relative risk and efficacy, the physician can better ensure the comfort and safety of the patient and the cost-effectiveness of medical care. A guideline is presented that recommends an approach to the evaluation of jaundice. It is based on a critical review of the literature and its application to clinical practice.
Efficacy of intracoronary or intravenous VEGF165in a pig model of chronic myocardial ischemia
Authors: Kaori Sato, Tiangen Wu, Roger J Laham, Robert B Johnson, Pamela Douglas, Jianyi Li, Frank W Sellke, Stuart Bunting, Michael Simons, Mark J Post
Journal: Journal of the American College of Cardiology (2001)
Phenylbutazone and Renal Function
Authors: B. M. Johnson, I. M. Larkin
Journal: BMJ (1954)

BLOOD-SUGAR ESTIMATION BRITASHblood-sugar colours within the range of the standards, in which case a factor would have to be applied to the answer.Results Blood sugars of 204 diabetics attending the Out-patients' Department of King's College Hospital were estimated by the Folin-Wu method and by the dinitrosalicylic acid method.The two series of estimations were made in different laboratories.The accompanying Graph compares the results of the blood-sugar determinations by the Folin-Wu method with those obtained by the present method.It can be seen that
Research on potential of bird flu virus to spread between humans is finally published
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Controversial research about a strain of avian flu that could potentially spread between humans has been published in Nature . It had been withheld from publication for five months after US advisers said that it posed security risks. A second paper is expected to appear soon in Science .

An editorial in Nature concludes that the lessons for publishers from the months of deliberations and meetings among scientists, security agencies, research journals, ethicists, and others is that “where there is a benefit to public health or science, publish!”1

A report of the research by a team from the University of Wisconsin-Madison was submitted to Nature in August last year, but publication was delayed after the US government’s biosecurity advisers warned that public health could be endangered if the trial’s methods fell into the wrong hands. …
Guidewire Fracture During Endoscopic Sphincterotomy
Authors: J. S. Burdick, M. J. Schmalz, J. E. Geenen
Journal: Endoscopy (1993)

Aberrant current conductance during an endoscopic sphincterotomy is a potential hazard. However, such complications have remained primarily theoretical. In this case report, we describe the fracture of a 0.018" Teflon-coated guidewire while performing a sphincterotomy with a 7 French, dual-chambered papillotome. The fractured guidewire was free and loose in the biliary tree, but was subsequently retrieved with endoscopic techniques. Inspection of the papillotome revealed charring of the plastic area adjacent to the cutting wire tip. The electrocautery unit was found to be in normal operating condition after formal testing. We speculate that the papillotome was defective, allowing current flow directly from the cutting wire to the guidewire. The small diameter guidewire then allowed a greater current density, resulting in heat which eventually contributed to fracture of the guidewire. Aberrant current can be conducted over a non-insulated guidewire. This potential hazard can be avoided with an insulated (coated) guidewire or removal of a non-insulated guidewire.
Elevated Levels of Interleukin-6 in Unstable Angina
Authors: Luigi M. Biasucci, Alessandra Vitelli, Giovanna Liuzzo, Sergio Altamura, Giuseppina Caligiuri, Claudia Monaco, Antonio G. Rebuzzi, Gennaro Ciliberto, Attilio Maseri
Journal: Circulation (1996)

Background Elevated plasma levels of C-reactive protein have been found in the majority of patients with unstable angina. The evidence of elevated levels of acute-phase proteins in unstable angina is in line with a growing body of evidence that suggests that inflammation plays a role in this syndrome and is an indirect sign of increased production of interleukin-6, which is the major determinant of acute-phase–protein production by the liver. However, in unstable angina, there is no direct proof of the role played by interleukin-6. Methods and Results We measured levels of interleukin-6 in 38 patients with unstable angina at the time of their admission to the coronary care unit and in 29 patients with stable angina. In the same groups of patients, we also measured C-reactive protein. Interleukin-6 (undetectable, ie, &lt;3 pg/mL, in healthy volunteers) was detectable in 23 (61%) of 38 patients with unstable angina but in only 6 (21%) of 29 with stable angina ( P &lt;.01). Median interleukin-6 levels were 5.25 pg/mL (range, 0 to 90 pg/mL) in patients with unstable angina but were below the detection limit of the assay in patients with stable angina (range, 0 to 7 pg/mL). A significant correlation was observed between interleukin-6 and C-reactive protein levels ( r =.4, P =.013). Conclusions Our study demonstrates that raised levels of interleukin-6 are common in unstable angina, correlate with C-reactive protein, and are associated with prognosis, thus confirming the importance of the cytokine pathway for the production by the liver of acute-phase proteins and strengthening the importance of inflammation in this syndrome. Further studies are required to elucidate better the role of interleukins in unstable angina.