Antagonists of Vasopressor and Antidiuretic Responses to Arginine Vasopressin
Authors: MAURICE MANNING
Journal: Annals of Internal Medicine (1982)

Editorials1 April 1982Antagonists of Vasopressor and Antidiuretic Responses to Arginine VasopressinMAURICE MANNING, PH.D., D.SC., WILBER H. SAWYER, M.D., PH.D.MAURICE MANNING, PH.D., D.SC., WILBER H. SAWYER, M.D., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-4-520 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn this issue Bichet and associates (1) present evidence that elevated levels of circulating vasopressin may be an important factor limiting water excretion by patients with hepatic cirrhosis. They also suggest that antagonists of the antidiuretic response would be useful in distinguishing the contribution of vasopressin to water retention from that of intrarenal factors. Such antagonists would not only be useful tools for studying the importance of endogenous vasopressin to water retention and hyponatremia in various clinical situations, but could also be valuable for treating hyponatremias.The design and synthesis of effective in-vivo antagonists of vasopressor and antidiuretic responses to...References1. BICHETSZATALOWICZCHAIMOVITZSCHRIER DVCR. Role of vasopressin in abnormal water excretion in cintiotic patients. Ann Intern Med. 1982;96:413-7. LinkGoogle Scholar2. DU VIGNEAUDGISHKATSOYANNIS VDP. A synthetic preparation possessing biological properties associated with arginine vasopressin. J Am Chem Soc. 1954;76:4751-2. CrossrefGoogle Scholar3. SAWYERGRZONKAMANNING WZM. Neurohypophysial peptides: Design of tissue-specific agonists and antagonists. Mol Cell Endocrinol. 1981;22:117-34. CrossrefMedlineGoogle Scholar4. MANNINGGRZONKASAWYER MZW. Synthesis of posterior pituitary hormones and hormone analogues. In: BEARDWELL C, ROBERTSON GL. The Pituitary. London: Butterworths International Medical Reviews; 1981:265-96. Google Scholar5. JARDBUTLENRAJERISONROY SDRC. The vasopressin-sensitive adenylate cyclase from the mammalian kidney. In: MOSES AM, SHARE L, eds. Neurohypophysis. S. Karger AG: Basel; 1977:211-9. Google Scholar6. SAWYERPANGSETOMCENROELAMMEKMANNING WPJMBM. Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone. Science. 1981;212:49-51. CrossrefMedlineGoogle Scholar7. MANNINGLAMMEKKOLODZIEJCZYKSETOSAWYER MBAJW. Synthetic antagonists of in vivo antidiuretic and vasopressor responses to arginine vasopressin. J Med Chem. 1981;24:701-6. CrossrefMedlineGoogle Scholar8. MANNINGLAMMEKKRUSZYNSKISETOSAWYER MBMJW. Design of potent and selective antagonists of the vasopressor responses to arginine vasopressin. J Med Chem. 1982;25:408-14. CrossrefMedlineGoogle Scholar9. MANNINGOLMAKLISKOLODZIEJCZYKSETOSAWYER MAWAJW. Design of more potent antagonists of the antidiuretic responses to arginine vasopressin. J Med Chem. 1982;25:45-50. CrossrefMedlineGoogle Scholar10. MANNINGKLISOLMASETOSAWYER MWAJW. Design of more potent and selective antagonists of the antidiuretic responses to arginine vasopressin devoid of antidiuretic agonism. J Med Chem. 1982;25:414-9. CrossrefMedlineGoogle Scholar11. SCHILD H. pA, a new scale for the measurement of drug antagonism. Br J Pharmacol Chemther. 1947;2:189-206. CrossrefMedlineGoogle Scholar12. COWLEYSWITZERGUINN ASM. Evidence and quantification of the vasopressin arterial pressure control system in the dog. Circ Res. 1980;46:58-67. CrossrefMedlineGoogle Scholar13. SCHWARTZREID JI. Effect of vasopressin blockade on blood pressure regulation during hemorrhage in conscious dogs. Endocrinology. 1981;109:1778-80. CrossrefMedlineGoogle Scholar14. ANDREWSBRENNER CB. Relative contributions of arginine vasopressin and angiotensin II to maintenance of systemic arterial pressure in the anesthetized water-deprived rat. Circ Res. 1981;48:254-8. CrossrefMedlineGoogle Scholar15. AISENBREYHANDELMANARNOLDMANNINGSCHRIER GWPMR. Vascular effects of arginine vasopressin during fluid deprivation in the rat. J Clin Invest. 1981;67:961-8. CrossrefMedlineGoogle Scholar16. CROFTONSHARESHADELEE-KWONMANNINGSAWYER JLRWMW. The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat. Hypertension. 1979;1:31-8. CrossrefMedlineGoogle Scholar17. MENTOWANGSAWYER PHW. Relative contributions of arginine vasopressin (AVP) and the sympathetic nervous system in maintaining DOC-salt hypertension in rats. Fed Proc. 1982;41:1230. Abstract. Google Scholar18. LE MOALKOOBKODA MGL. Vasopressor receptor antagonist prevents behavioural effects of vasopressin. Nature. 1981;291:491-3. CrossrefMedlineGoogle Scholar19. LOHMEIERSMITHCOWLEYMANNINGGUYTON TMARA. Is vasopressin an important hypertensive hormone? Hypertension. 1981;3:416-25. CrossrefMedlineGoogle Scholar20. BARTTERSCHWARTZ FW. The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med. 1967;42:790-806. CrossrefMedlineGoogle Scholar21. ZERBEBAYLISROBERTSON RPG. Vasopressin function in clinical disorders of water balance. In: BEARDWELL C, ROBERTSON GL. The Pituitary. London: Butterworths International Medical Reviews; 1981:297-329. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Pharmacology College of Physicians & Surgeons of Columbia University New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByVasopressin Receptor AntagonistsVasopressin: A therapeutic target in congestive heart failure?Role of Vasopressin Deficiency in the Vasodilation of Septic ShockSignificant hyponatremia following DDAVP administration in a healthy adultReceptor-mediated stimulation of taurocholate efflux from the rat hepatocyte and the ex vivo perfused rat liverPressor hormones regulate atrial-stretch-induced release of atrial natriuretic peptide in the pithed rat.In vitro inhibition of gastric acid secretion by vasopressinVasopressin as vasopressorDesensitization of renal vasopressin-stimulated adenylate cyclase by a vasopressor and antidiuretic antagonist, [1-(β-mercapto-β,β-cyclo-pentamethylenepropionic acid),2-(0-ethyl)-D-tyrosine, 4-valinelarginine vasopressinPathogenesis of clinical hyponatremia: observations of vasopressin and fluid intake in 100 hyponatremic medical patientsSelective Agonists and Antagonists of VasopressinModulation of membrane transport of alkylating agents and amino acids by an analog of vasopressin in murine L5178Y lymphoblasts in vitroHemodynamic effects of infused arginine vasopressin in congestive heart failureArginine vasopressin and the renal response to water loading in congestive heart failureRole of vasopressin in stimulation of ACTH secretion by angiotensin II in conscious dogsCardiovascular effects associated with antidiuretic activity of vasopressin after blockade of its vasoconstrictor action in dehydrated dogs.Kardiovaskuläre Wirkung des antidiuretischen Hormons Arginin-VasopressinDrugs Five Years Later: DesmopressinDONALD W. RICHARDSON, M.D., ALAN G. ROBINSON, M.D.Vasopressin-Stimulated Release of Atriopeptin: Endocrine Antagonists in Fluid HomeostasisThe Role of Vasopressin in Experimental and Clinical HypertensionHyponatremia: A Prospective Analysis of Its Epidemiology and the Pathogenetic Role of VasopressinROBERT J. ANDERSON, M.D., HSIAO-MIN CHUNG, M.D., RUDIGER KLUGE, M.D., ROBERT W. SCHRIER, M.D.Vasopressin, Cardiovascular Regulation, and HypertensionThe Neurohumoral Axis in Congestive Heart FailureGARY S. FRANCIS, M.D., STEVEN R. GOLDSMITH, M.D., T. BARRY LEVINE, M.D., MARIA TERESA OLIVARI, M.D., JAY N. COHN, M.D.Centrally administered PGE2 inhibits gastric secretion in the rat by releasing vasopressinDesign and uses of selective agonistic and antagonistic analogs of the neuropeptides oxytocin and vasopressinSkin Blood Flow and Cigarette Smoking: the Role of VasopressinBlood pressure and heart rate effect of a vasopressin antagonist in conscious normotensive rats pretreated with exogenous vasopressinDevelopment of a new strain of spontaneously hypertensive rats homozygous for hypothalamic diabetes insipidus.On the role of prostaglandins in brain mechanisms controlling blood pressureDesign of Potent and Selective In Vivo Antagonists of the Neurohypophysial Peptides 1 April 1982Volume 96, Issue 4Page: 520-522KeywordsArginineCirrhosisExcretionHyponatremiaVasopressinVasopressors Issue Published: 1 April 1982 PDF DownloadLoading ...