tbuckley/cabot-search huggingface dataset:
P117 Comparison of indices of nutritional status in prediction of in-hospital mortality and early readmission of patients with acute exacerbations of COPD
Authors: J. Steer, E. Norman, G. J. Gibson, S. C. Bourke
Journal: Thorax (2010)

<h3>Introduction and objectives</h3> In patients hospitalised with an acute exacerbation of COPD (AECOPD), low body mass index (BMI) predicts in-hospital death. The Malnutrition Universal Screening Tool (MUST) incorporates BMI and patient-reported weight loss over the previous 6 months to provide an overall assessment of malnutrition risk. It predicts mortality in elderly hospitalised patients1 but, to our knowledge, the prognostic value of this tool in AECOPD has not been previously reported. <h3>Methods</h3> We prospectively identified patients hospitalised with AECOPD. We investigated the ability of BMI, self-reported weight loss and MUST score to predict in-hospital mortality and 28-day readmission. BMI &lt;18.5 kgm<sup>−2</sup> was considered underweight (World Health Organisation, 2004). Odds Ratios (OR) were calculated using normal BMI, weight loss &lt;5%, and MUST score 0 as reference values. <h3>Results</h3> 608 patients were included; mean (SD) age 72.8 (10.2) years, 55.8% female, mean (SD) FEV<sub>1</sub> (if performed within 2 years of admission, n=398) 43.5 (18) % predicted. 61 (10%) patients died in-hospital (6.9% in those with simple exacerbations, 16.5% in exacerbations associated with pneumonia). Of patients surviving to discharge, 95 (17.4%) were readmitted within 28 days (Abstract P117 Table 1). In-hospital mortality was predicted by BMI &lt;18.5 kgm<sup>−2</sup> (OR 2.5, 95% CI 1.27 to 4.91, p=0.008) whereas weight loss &gt;10% predicted early readmission (OR 3.90, 95% CI 2.09 to 7.28, p&lt;0.001). A high risk of malnutrition (MUST ≥2) was the only measurement that significantly predicted both in-hospital mortality (OR 2.10, 95% CI 1.18 to 3.74, p=0.011) and early readmission to hospital (OR 1.71, 95% CI 1.04 to 2.83, p=0.034). BMI within the overweight range appeared to be protective against early readmission (OR 0.54, 95% CI 0.29 to 0.99, p=0.046). <h3>Conclusion</h3> In patients hospitalised with AECOPD, indices of nutritional status are important predictors of outcome. Of interest, BMI and self-reported weight loss predict different outcome measures (in-hospital death and early readmission respectively). A high risk of malnutrition (MUST score ≥2) is potentially a useful predictor of both in-hospital mortality and early hospital readmission and we suggest that it should be assessed routinely.
Balancing the Risks and Benefits of Dual Platelet Inhibition
Authors: John F. Keaney
Journal: New England Journal of Medicine (2015)

Cardiovascular and cerebrovascular events commonly arise from atherosclerotic plaque rupture that produces platelet activation, thrombus formation, and reduction of blood flow to the brain or heart. The inhibition of platelets with aspirin is effective in the secondary prevention of acute coronary events.1 The addition of clopidogrel (i.e., dual antiplatelet therapy), a platelet P2Y12-receptor antagonist, produces even greater secondary prevention of coronary events in high-risk patients for up to 1 year.2 Second-generation P2Y12 inhibitors (i.e., prasugrel and ticagrelor) produce further reductions in the risk of ischemic events over the same time frame, albeit with more bleeding complications.3, . . .
More Impact of Microalbuminuria on Retinopathy Than Moderately Reduced GFR Among Type 2 Diabetic Patients
Authors: Yu-Hsin Chen, Harn-Shen Chen, Der-Cherng Tarng
Journal: Diabetes Care (2012)

The current study aimed to investigate whether microalbuminuria or moderately decreased glomerular filtration rate (GFR) is a better predictor for the development and progression of retinopathy in type 2 diabetic patients.Type 2 diabetic patients without cardiovascular diseases, malignancy, pregnancy, and acute intercurrent illness were enrolled between 1 August 2001 and 31 December 2002. All participants provided their detailed medical history and underwent an eye fundus examination. They were followed up in outpatient clinics, and serum creatinine, urinary albumin-to-creatinine ratio (UACR), and retinal photographs were followed up annually until 31 December 2009. The primary outcomes were development and progression of diabetic retinopathy and nephropathy. The secondary outcomes were cardiovascular events and all-cause mortality.Among 487 participants, 81 subjects had normoalbuminuria and moderate renal impairment (baseline eGFR 30-59.9 mL/min/1.73 m(2)), and 106 subjects had microalbuminuria and baseline eGFR ≥60 mL/min/1.73 m(2). Patients with microalbuminuria and eGFR ≥60 mL/min/1.73 m(2) had a significantly greater risk for development and progression of diabetic retinopathy (HR 3.34 [95% CI 1.04-10.70]) compared with those with moderate renal impairment and normoalbuminuria after multivariate adjustment. Risks for renal outcome, cardiovascular events, and all-cause mortality were not significantly different between the two groups.Microalbuminuria has a greater impact on predicting the development and progression of diabetic retinopathy compared with moderate decline in GFR among type 2 diabetic patients.
Impaired natural killer cell self-education and “missing-self” responses in Ly49-deficient mice
Authors: Simon Bélanger, Megan M. Tu, Mir Munir Ahmed Rahim, Ahmad B. Mahmoud, Rajen Patel, Lee-Hwa Tai, Angela D. Troke, Brian T. Wilhelm, Josette-Renée Landry, Qinzhang Zhu, Kenneth S. Tung, David H. Raulet, Andrew P. Makrigiannis
Journal: Blood (2012)
Familial Hypercholesterolemia: A Genetic and Metabolic Study.
Authors: William R. Harlan
Journal: Annals of Internal Medicine (1965)

Abstracts1 November 1965Familial Hypercholesterolemia: A Genetic and Metabolic Study.Authors: William R. Harlan Jr., M.D., John H. Graham, M.D., and E. Harvey Estes, M.D. (Associate)Author, Article, & Disclosure InformationPublication: Annals of Internal MedicineVolume 63, Number 5https://doi.org/10.7326/0003-4819-63-5-915_3 Get AccessSubmit a CommentContributors must reveal any conflict of interest. Comments are moderated. Please see our information for authorsregarding comments on an Annals publication.Name (if multiple authors, separate names by comma)Name field is requiredComment TitleTitle field is requiredAffiliation & Institution (max characters: 200)Affiliations field is requiredCommentComment field is requiredPlease disclose any conflicts of interest or leave the box unchecked if you have noneDisclosure of Any Conflicts of InterestCancelSubmit
EMPLOYMENT OF BUS OPERATORS WITH MYOCARDIAL DAMAGE
Authors: O. P. J. Falk
Journal: JAMA (1952)

<h3>To the Editor:—</h3> I am interested in a policy for the rehabilitation and employment of young adult and middle-aged bus and streetcar operators who have completely recovered from coronary thrombosis with myocardial infarction. In spite of the fact that it appears to be an accepted policy for companies engaged In transportation to grant permanent disability pensions when such a plan exists to employes in this category, it is my feeling that this policy should be modified for the reasons given below. My personal clinical experience is that the majority of patients recovering from their initial coronary attack can return to an occupation not associated with undue physical strain or mental stress. We have many cases among our records of men in all walks of life, including farmers, industrial workers, professional men, and executives, who are leading perfectly normal lives and experiencing no symptoms of difficulty. When they do, we naturally
FRAGMENTED QRS PREDICTS CARDIAC EVENTS IN HYPERTROPHIC CARDIOMYOPATHY
Authors: Akihiro Nomura, Tetsuo Konno, Takashi Fujita, Yoshihiro Tanaka, Shohei Yoshida, Kenshi Hayashi, Kenji Sakata, Masa-aki Kawashiri, Noboru Fujino, Masakazu Yamagishi
Journal: Journal of the American College of Cardiology (2014)
THE TREATMENT OF DISEASES OF PIGMENTATION.
Authors: JOHN V. SHOEMAKER
Journal: JAMA (1899)

A clear complexion is one of the elements of personal comeliness. A very large proportion of people who seek the dermatologist do so on account of some more or less pronounced defect in the normal and healthy coloring of the skin, especially of the exposed parts. It is needless to say that most of these patients are women. Women are naturally more annoyed and mortified by such blemishes than men. Pigmentary diseases of the skin range from the most trivial to the most serious ailment. Some involve but a slight departure from the normal, others cause extremely dark and unsightly lesions. In most cases the pigmentation is increased or modified in hue, but in a certain number it is diminished. Most diseases in which the pigment of the skin is affected depend upon some more or less grave constitutional cause. A few are merely local disorders. <h3>Lentigo.</h3> —This is one
ABC of heart failure: Non-drug management
Authors: C R Gibbs, G Jackson, G Y Lip
Journal: BMJ (2000)

Approaches to the management of heart failure can be both non-pharmacological and pharmacological; each approach complements the other. This article will discuss non-pharmacological management.

#### Non-pharmacological measures for the management of heart failure

Effective counselling and education of patients, and of the relatives or carers, is important and may enhance long term adherence to management strategies. Simple explanations about the symptoms and signs of heart failure, including details on drug and other treatment strategies, are valuable. Emphasis should be placed on self help strategies for each patient; these should include information on the need to adhere to drug treatment. Some patients can be instructed how to monitor their weight at home on a daily basis and how to adjust the dose of diuretics as advised; sudden weight increases (>2 kg in 1-3 days), for example, should alert a patient to alter his or her treatment or seek advice.

Urging patients to alter their lifestyle is important in the management of chronic heart failure. Social activities should be encouraged, however, and care should be taken to ensure that patients avoid social isolation. If possible, patients should continue their regular work, with adaptations to accommodate a reduced physical capacity where appropriate.



Self help strategies for patients with heart failure



### Contraceptive advice

Advice on contraception should be offered to women of childbearing potential, particularly those patients with …
Wrist 12 versus wrist plus: twelve versus six months of clopidogrel for prevention of late total occlusion after gamma radiation therapy for in-stent restenosis
Authors: Ron Waksman, Andrew E. Ajani, Dong-Hun Cha, Daniella Claus, Regina Deible, Ellen Pinnow, Hongsheng Wu, Augusto D. Pichard, Lowell F. Satler, Kenneth M. Kent, Joseph Lindsay
Journal: Journal of the American College of Cardiology (2002)
A solid angle analysis of the epicardial ischemic TQ-ST deflection in the pig. A theoretical and experimental study.
Authors: J F Richeson, T Akiyama, E Schenk
Journal: Circulation Research (1978)

The solid angle theory has long been applied to the interpretation of the ECG; however, quantitative evaluation of its applicability has been minimal. We applied solid angle analysis to the interpretation of the TQ-ST deflection during acute ischemia. Five anesthetized pigs were studied 1--3 hours after coronary occlusion. Multiple unipolar tracings were recorded from precisely determined positions on the epicardium overlying the ischemic and normal zones. The geometry of the hearts and ischemic zones was preserved, the margins of ischemia being defined as the outer border of Thioflavin S nonfluorescence. Wax replicas of the hearts with ischemic zones removed were constructed. Solid angles subtended at electrode positions on the replicas were calculated. A linear relationship (r = 0.84 - 0.97, P less than 0.001) was shown to exist between the observed TQ-ST deflection and the calculated solid angle. A small but patterned deviation from exact fit of the TQ-ST deflection with the calculated solid angle led us to investigate the possibility that dipole moment strength (phi) is not confined to the ischemic margins. Computations using idealized heart models with ischemic zones cylindrical and transmural in shape allowed us to distribute phi arbitrarily within the ischemic zone, comparing this predicted pattern of TQ-ST deflection with that observed experimentally. The experimental data appear most consistent with the condition in which phi is distributed over a 1-cm border region during the first several hours of ischemia. We conclude that the solid angle theory provides a rational basis for interpretation of the ischemic TQ-ST deflection; however, phi may be distributed over a marginal zone.
Whole genome sequencing and phylogenetic analysis of West Nile virus lineage 1 and lineage 2 from human cases of infection, Italy, August 2013
Authors: L Barzon, M Pacenti, E Franchin, E Lavezzo, G Masi, L Squarzon, S Pagni, S Toppo, F Russo, M Cattai, R Cusinato, G Palù
Journal: Eurosurveillance (2013)

A human outbreak of West Nile virus (WNV) infection caused by WNV lineage 2 is ongoing in northern Italy. Analysis of six WNV genome sequences obtained from clinical specimens demonstrated similarities with strains circulating in central Europe and Greece and the presence of unique amino acid changes that identify a new viral strain. In addition, WNV lineage 1 Livenza, responsible for a large outbreak in north-eastern Italy in 2012, was fully sequenced from a blood donor during this 2013 outbreak.
Oxacillin and Hepatitis
Authors: CHARLES TAYLOR
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 May 1979Oxacillin and HepatitisCHARLES TAYLOR, M.D., KATHY CORRIGAN, M.D., SUSAN STEEN, M.D., CHARLES CRAIG, M.D.CHARLES TAYLOR, M.D.Search for more papers by this author, KATHY CORRIGAN, M.D.Search for more papers by this author, SUSAN STEEN, M.D.Search for more papers by this author, CHARLES CRAIG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-5-857 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We report a case that sheds further light on the anicteric hepatitis induced by intravenous high-dose oxacillin therapy, reviewed by Onorato and Axelrod in the October 1978 issue (1).A 24-year-old man was hospitalized due to a 2-week history of severe pain in the left sacral area, associated with fever to 39.5 °C and shaking chills. He reported a recent laceration of the left foot that healed slowly, with erythema and exudate. There was no past history of hepatitis, jaundice, intravenous drug use, allergies, blood transfusions, exposure to hepatotoxins, or significant alcohol consumption. Physical examination showed temperature...References1. ONORATOAXELROD IJ: Hepatitis from intravenous high-dose oxacillin therapy. Findings in an adult inpatient population. Ann Intern Med 89:497-500, 1978 LinkGoogle Scholar2. DISMUKES W: Oxacillin-induced hepatic dysfunction. JAMA 226:861-863, 1973 CrossrefMedlineGoogle Scholar3. BRUCKSTEINATTIA AA: Oxacillin hepatitis. Two patients with liver biopsy, and review of the literature. Am J Med 64:519-522, 1978 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of South Florida College of Medicine Tampa, FL 33612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced Liver DiseaseNafcillin-associated hepatotoxicityHepatic and Renal Dysfunction following Nafcillin AdministrationAdverse Effects of Drugs on the LiverFlucloxacillin-induced Cholestatic Liver DamageFlucloxacillin-induced Cholestatic Liver DamageColonoscopy in the Prevention, Detection and Treatment of Large Bowel CancerPenicillins, cephalosporins and tetracyclines 1 May 1979Volume 90, Issue 5Page: 857-858KeywordsAllergy and immunologyBlood transfusionDrugsErythemaFeversHepatitisHepatitis AHepatotoxinsLacerationsTemperature Issue Published: 1 May 1979 PDF downloadLoading ...
Sexually Transmitted Diseases and Other Risk Factors for Cervical Dysplasia Among Southwestern Hispanic and Non-Hispanic White Women
Authors: Thomas M. Becker
Journal: JAMA (1994)

To assess risk factors for high-grade cervical dysplasia among southwestern Hispanic and non-Hispanic white women.Clinic-based case-control study.University-affiliated gynecology clinics.Cases were Hispanic and non-Hispanic white women with biopsy-proven high-grade cervical dysplasia (n = 201). Controls were Hispanic and non-Hispanic white women from the same clinics with normal cervical epithelium (n = 337).Study design included interviews focused on histories of sexually transmitted diseases, sexual behavior, reproductive histories, hygienic practices, contraceptive use, cigarette smoking, and diet. Laboratory studies included bacterial and protozoal cultures of the cervix; hybridization tests to identify human papillomavirus (HPV) genome with commercial (ViraPap and ViraType) and polymerase chain reaction-based assays; and serum antibody tests for herpes simplex virus, Chlamydia trachomatis, syphilis, hepatitis B, and hepatitis C.For both ethnic groups combined, after adjustment for ethnicity, age, and sexual behavior, the strongest risks for cervical dysplasia were associated with cervical HPV infection as identified by ViraPap (odds ratio [OR], 12.8; 95% confidence interval [CI], 8.2 to 20.0) or with polymerase chain reaction (OR, 20.8; 95% CI, 10.8 to 40.2). Other factors associated with dysplasia included cigarette smoking at the time of diagnosis (OR, 1.8; 95% CI, 1.2 to 2.8); low income (OR, 2.2; 95% CI, 1.2 to 4.0); low educational level (OR, 6.2; 95% CI, 3.4 to 11.1); history of any sexually transmitted disease (OR, 1.9; 95% CI, 1.3 to 2.7); and seroprevalence of antibodies to hepatitis B (OR, 1.8; 95% CI, 0.9 to 3.5). For Hispanic women, HPV 16/18 identified by ViraType was strongly associated with cervical dysplasia (OR, 171.0; 95% CI, 22.8 to 1280.5). Antibodies to herpes simplex virus type 2 were not associated with dysplasia in Hispanic women but were significantly associated with dysplasia among non-Hispanic whites. Risks associated with cigarette smoking also varied by ethnic group.The strongest risk factor associated with high-grade cervical dysplasia among clinic attendees was HPV infection. Although most of the risk factors we examined showed similar associations for dysplasia for both ethnic groups, our data suggest that several different risk factors may be relevant to the development of cervical dysplasia in Hispanics compared with non-Hispanic whites who attend the same clinics.
Expansion of vitiligo lesions is associated with reduced epidermal CDw60 expression and increased expression of HLA-DR in perilesional skin
Authors: I.C. Le Poole, L.S. Stennett, B.K. Bonish, L. Dee, J.K. Robinson, C. Hernandez, S.K. Hann, B.J. Nickoloff
Journal: British Journal of Dermatology (2003)

Journal Article Expansion of vitiligo lesions is associated with reduced epidermal CDw60 expression and increased expression of HLA‐DR in perilesional skin Get access I.C. Le Poole, I.C. Le Poole Department of Pathology, Cardinal Bernardin Cancer Center Rm 203, Loyola University, 2160 South First Avenue, Maywood, Chicago, IL 60153, U.S.A. *Department of Dermatology, Yonsei University, Seoul, Korea I.Caroline Le Poole Ph.D. E‐mail: ilepool@lumc.edu Search for other works by this author on: Oxford Academic Google Scholar L.S. Stennett, L.S. Stennett Department of Pathology, Cardinal Bernardin Cancer Center Rm 203, Loyola University, 2160 South First Avenue, Maywood, Chicago, IL 60153, U.S.A. *Department of Dermatology, Yonsei University, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar B.K. Bonish, B.K. Bonish Department of Pathology, Cardinal Bernardin Cancer Center Rm 203, Loyola University, 2160 South First Avenue, Maywood, Chicago, IL 60153, U.S.A. *Department of Dermatology, Yonsei University, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar L. Dee, L. Dee Department of Pathology, Cardinal Bernardin Cancer Center Rm 203, Loyola University, 2160 South First Avenue, Maywood, Chicago, IL 60153, U.S.A. *Department of Dermatology, Yonsei University, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar J.K. Robinson, J.K. Robinson Department of Pathology, Cardinal Bernardin Cancer Center Rm 203, Loyola University, 2160 South First Avenue, Maywood, Chicago, IL 60153, U.S.A. *Department of Dermatology, Yonsei University, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar C. Hernandez, C. Hernandez Department of Pathology, Cardinal Bernardin Cancer Center Rm 203, Loyola University, 2160 South First Avenue, Maywood, Chicago, IL 60153, U.S.A. *Department of Dermatology, Yonsei University, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar S.K. Hann, S.K. Hann Department of Pathology, Cardinal Bernardin Cancer Center Rm 203, Loyola University, 2160 South First Avenue, Maywood, Chicago, IL 60153, U.S.A. *Department of Dermatology, Yonsei University, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar B.J. Nickoloff B.J. Nickoloff Department of Pathology, Cardinal Bernardin Cancer Center Rm 203, Loyola University, 2160 South First Avenue, Maywood, Chicago, IL 60153, U.S.A. *Department of Dermatology, Yonsei University, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 4, 1 October 2003, Pages 739–748, https://doi.org/10.1046/j.1365-2133.2003.05539.x Published: 01 October 2003 Article history Accepted: 25 November 2002 Published: 01 October 2003
You Must Be Dreaming
Authors: Margaret C. Fraser
Journal: JAMA (1993)

<i>You Must Be Dreaming</i>is written by a former patient of Dr Jules Masserman, a prominent and powerful psychiatrist. Dr Masserman is past president of the American Psychiatric Association (APA) and the American Academy of Psychoanalysis and honorary president for life of the World Association for Social Psychiatry. The book, written by Barbara Noel with Kathryn Watterson, documents psychiatric treatment that can only be characterized as the malicious abuse of power. Ms Noel is a singer and composer who first sought help from Dr Masserman in 1966 with complaints of marital difficulties and performance anxiety. Trusting this world-renowned psychiatrist and believing she was involved in a normal therapeutic relationship, she describes years of treatment marked by violations of the most basic principles of appropriate psychiatric care. Dr Masserman gave his patients gifts and exchanged copies of articles and poems he had written. He asked his patient to his home and