tbuckley/cabot-search huggingface dataset:
Nadroparin in the Prevention of Deep Vein Thrombosis in Acute Decompensated COPD
Authors: FRANÇOIS FRAISSE, LAURENT HOLZAPFEL, JEAN-MICHEL COULAND, GERALD SIMONNEAU, BERNARD BEDOCK, MARC FEISSEL, PATRICK HERBECQ, REGINALD PORDES, JEAN-FRANÇOIS POUSSEL, LOUIS ROUX
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Low molecular weight heparins are as effective as unfractionated heparin in deep-vein thrombosis (DVT) prophylaxis for major surgery. However, there is no evidence nor consensus for prophylaxis in medical patients. We compared the efficacy and safety of nadroparin calcium (nadroparin) with placebo in medical patients at high risk of DVT. A total of 223 patients mechanically ventilated for acute, decompensated chronic obstructive pulmonary disease, were randomized to treatment with subcutaneous nadroparin adjusted for body weight (0.4 ml, i.e., 3,800 AXa IU, or 0.6 ml, i.e., 5,700 AXa IU) or placebo. The average duration of treatment was 11 d. The incidence of DVT in patients receiving nadroparin was significantly lower than that in patients receiving placebo (15.5 versus 28.2%; p = 0.045). Although the incidence of adverse events was high in both groups, there were no significant differences between nadroparin and placebo for total adverse events (46.3 versus 39.8%; p = 0.33), serious adverse events (25.0 versus 19.5%; p = 0.32), or those resulting in early permanent discontinuation of treatment (12.0 versus 8.8%; p = 0.44). The most common adverse event was hemorrhage. There was the same number of deaths in both treatment groups. Subcutaneous nadroparin resulted in 45% decrease in incidence of DVT compared with placebo.
Effect of hyperosmotic perfusion on rate of oxygen consumption of isolated guinea pig and rat hearts during cardioplegia
Authors: P. J Hanley, P. J Cooper, D. S Loiselle
Journal: Cardiovascular Research (1994)

Journal Article Effect of hyperosmotic perfusion on rate of oxygen consumption of isolated guinea pig and rat hearts during cardioplegia Get access Peter J Hanley, Peter J Hanley Department of Physiology, School of Medicine, University of Auckland, Auckland, New Zealand: P J Hanley, P J Cooper, D S Loiselle. Correspondence to Dr Loiselle. Search for other works by this author on: Oxford Academic PubMed Google Scholar Patricia J Cooper, Patricia J Cooper Department of Physiology, School of Medicine, University of Auckland, Auckland, New Zealand: P J Hanley, P J Cooper, D S Loiselle. Search for other works by this author on: Oxford Academic PubMed Google Scholar Denis S Loiselle Denis S Loiselle Department of Physiology, School of Medicine, University of Auckland, Auckland, New Zealand: P J Hanley, P J Cooper, D S Loiselle. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 4, April 1994, Pages 485–493, https://doi.org/10.1093/cvr/28.4.485 Published: 01 April 1994 Article history Received: 21 July 1993 Accepted: 08 November 1993 Published: 01 April 1994
F-18 FDG PET/CT Uptake by a Cardiac Hemangioma
Authors: Isabel Martínez-Rodríguez, Ignacio Banzo, Remedios Quirce, Julio F. Jiménez-Bonilla, Pamela Medina-Quiroz, Adriana S. Rubio-Vassallo, Jose M. Carril
Journal: Clinical Nuclear Medicine (2010)

A 16-year-old girl presented with intermittent dyspnea, chest oppression, and dizziness on exertion. Transthoracic echocardiography revealed a vascularized mass in the left ventricle. Cardiac gadolinium-enhanced magnetic resonance imaging (CMRI) showed a solid mass in the left ventricular apex and minimal bilateral pleural and pericardial effusions. This mass showed an intense contrast enhancement and a high perfusion. F-18 fluoro-deoxy-glucose (FDG) positron emission tomography and computed tomography (PET/CT) showed a focal uptake in the left ventricular apex with no evidence of abnormal extracardiac uptake. This is a report of FDG uptake by a cardiac hemangioma.
ARTERIAL INFLAMMATION IS HIGHER IN INDIVIDUALS WITH CHRONIC KIDNEY DISEASE AND LOW FRAMINGHAM RISK SCORES
Authors: Megan H. MacNabb, Amr Abdelbaky, Zachary R. Lavender, Rebecca S. Kaplan, Marcelo di Carli, Viviany Taqueti, Courtney Foster, Jessica Mann, Robert Comley, Chek Ing Kiu Weber, Ahmed Tawakol
Journal: Journal of the American College of Cardiology (2013)
Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain
Authors: Katharina Lückerath, Vladimir Kirkin, Inga Maria Melzer, Frederic B. Thalheimer, Dagmar Siele, Wiebke Milani, Thure Adler, Antonio Aguilar-Pimentel, Marion Horsch, Geert Michel, Johannes Beckers, Dirk H. Busch, Markus Ollert, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabĕ de Angelis, Frank J. T. Staal, Krishnaraj Rajalingam, Anne-Odile Hueber, Lothar J. Strobl, Ursula Zimber-Strobl, Martin Zörnig
Journal: Blood (2010)
Spurious Hypochloremia and Renal Insufficiency
Authors: MELISSA J. SCHIFF
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 March 1985Spurious Hypochloremia and Renal InsufficiencyMELISSA J. SCHIFF, M.D., ANTHONY L. SUCHMAN, M.D.MELISSA J. SCHIFF, M.D.Search for more papers by this author, ANTHONY L. SUCHMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-3-420_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent report (1) has described falsely low serum chloride values measured by the Kodak Ektachem Analyzer (Eastman Kodak Co., Rochester, New York). We report three additional cases.A 64-year-old woman with diabetes mellitus, hypertension, and atherosclerotic cardiovascular disease was hospitalized for exacerbation of congestive heart failure. While continuing her usual doses of digoxin, insulin, prazosin, diltiazem, procainamide, and allopurinol (300 mg/d), she was treated vigorously with furosemide and metolazone, resulting in azotemia (creatinine level, 3.8 mg/dL). Her serum chloride level was reported to be 67 mg/dL with a calculated anion gap of 33. However, her PCO2...References1. POTTERSHANKJOHNSONNEAL JLDD. Interference with Ektachem 400 determinations of chloride in a leukemia patient treated with allopurinol [Letter]. Clin Chem. 1984;30:113-4. CrossrefGoogle Scholar2. MILLER G. Chloride. In: KAPLAN LA, PESCE AJ, eds. Clinical Chemistry: Theory, Analysis, and Correlation. St. Louis: C.V. Mosby Co.; 1984:1059-61. Google Scholar3. LEWIS A ed. Modern Drug Encyclopedia. New York: Yorke Medical Books; 1981:43-6. Google Scholar4. Instruction Manual: Test Methodology—Kodak Ektachem. Rochester, New York: Eastman Kodak Company; 1981. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Rochester School of Medicine and Dentistry Highland Hospital Rochester, NY 14620 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1985Volume 102, Issue 3Page: 420-421KeywordsAllopurinolAnionsAtherosclerotic cardiovascular diseaseChloridesCreatinineDiabetes mellitusHeart failureHypertensionInsulinPartial pressure of carbon dioxide Issue Published: 1 March 1985 PDF downloadLoading ...
ARTIFICIAL DILATATION OF THE CERVIX UTERI WITH A NEW INSTRUMENT.
Authors: FRANK A. HIGGINS
Journal: JAMA (1903)

Artificial dilatation of the cervix uteri during labor is a well-recognized obstetric expedient, which is not only of great value in certain cases as a means of accelerating tedious labor, but also becomes an absolutely necessary method of procedure in many instances where the life of the mother or of the child may be dependent on prompt delivery. The problem of the safe and efficient mechanical dilatation of the rigid cervix of the pregnant uterus is an interesting one which has not as yet been entirely and satisfactorily solved, although there are many methods and a considerable number of instruments devised for the purpose. Under the head of mechanical dilatation of the cervix the writer would include all forms' of artificial dilatation whether performed by the hand, by dilating bags, or by instruments. Bougies and gauze introduced into the uterus, the latter device being known as tamponade of the cervix,
Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice
Authors: Z Yao
Journal: Annals of the Rheumatic Diseases (2004)

To characterise cartilage intermediate layer protein (CILP)-induced arthropathy in mice.The first and second halves of the nucleotide triphosphate pyrophosphohydrolase (NTPPHase) non-homologous region of human CILP were prepared as recombinant proteins (C1 and C2, respectively), including three overlapping fragments of C2 (C2F1, C2F2, and C2F3). C57BL/6 mice were immunised with these proteins to induce arthritis. In addition, a separate group of mice were immunised repeatedly with the mixture of C1 and C2 to see the effect of chronic immunisation. Arthritis developed in the mice, and cellular and humoral immune responses against CILP were analysed.Immunisation with C2 and with the mixture C2F1/C2F2/C2F3 caused the severest arthritis to develop in mice. Immunisation with one of C1, C2F1, C2F2, or C2F3 caused milder arthritis, even though each of the fragments carried T cell epitopes. Immunisation either with C1 or C2 alone evoked cellular and humoral immune responses to both the C1 and C2 proteins. Further, the repeated immunisation with the C1/C2 mixture caused tendon calcification and bone irregularity, together with decreased NTPPH activity.The results show that multiple T cell epitopes are needed for the development of CILP-induced arthritis, and present the characteristic new model of mild arthropathy accompanied by extra-articular calcifications. An immune response to putative murine CILP/NTPPH may be involved in the ectopic calcifications in the arthritic mice.
CORONARY MICROVASCULAR DYSFUNCTION IS AN INDEPENDENT PREDICTOR OF THE NEW ONSET OF CORONARY EPICARDIAL STENOSIS IN HEART TRANSPLANT PATIENTS
Authors: Giulia Famoso, Martina Previato, Marny Fedrigo, Annalisa Angelini, Giuseppe Tarantini, Gino Gerosa, Sabino Iliceto, Francesco Tona
Journal: Journal of the American College of Cardiology (2013)
Migraine on the Rise
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Caveolin-1 Facilitates Mechanosensitive Protein Kinase B (Akt) Signaling In Vitro and In Vivo
Authors: Daniel G. Sedding, Jennifer Hermsen, Ulrike Seay, Oliver Eickelberg, Wolfgang Kummer, Carsten Schwencke, Ruth H. Strasser, Harald Tillmanns, Ruediger C. Braun-Dullaeus
Journal: Circulation Research (2005)

Mechanotransduction represents an integral part of vascular homeostasis and contributes to vascular lesion formation. Previously, we demonstrated a mechanosensitive activation of phosphoinositide 3-kinase (PI3-K)/protein kinase B (Akt) resulting in p27 Kip1 transcriptional downregulation and cell cycle entry of vascular smooth muscle cells (VSMC). In this study, we further elucidated the signaling from outside-in toward PI3-K/Akt in vitro and in an in vivo model of elevated tensile force. When VSMC were subjected to cyclic stretch (0.5 Hz at 125% resting length), PI3-K, Akt, and Src kinases were found activated. Disrupting caveolar structures with β-cyclodextrin or transfection of VSMC with caveolin-1 antisense oligonucleotides (ODN) prevented PI3-K and Akt activation and cell cycle entry. Furthermore, PI3-K and Akt were resistant to activation when Src kinases were inhibited pharmacologically or by overexpression of a kinase-dead c-Src mutant. α V β 3 integrins were identified to colocalize with PI3-K/caveolin-1 complexes, and blockade of α V β 3 integrins prevented Akt activation. The central role of caveolin-1 in mechanotransduction was further examined in an in vivo model of elevated tensile force. Interposition of wild-type (WT) jugular veins into WT carotid arteries resulted in a rapid Akt activation within the veins that was almost abolished when veins of caveolin-1 knockout (KO) mice were used. Furthermore, late neointima formation within the KO veins was significantly reduced. Our study provides evidence that PI3-K/Akt is critically involved in mechanotransduction of VSMC in vitro and within the vasculature in vivo. Furthermore, caveolin-1 is essential for the integrin-mediated activation of PI3-K/Akt.
Significance of IgM antibody to hepatitis C virus in patients with chronic hepatitis C
Authors: Stefano Brillanti, Caterina Masci, Piero Ricci, Mario Miglioli, Luigi Barbara
Journal: Hepatology (1992)

We assessed the correlation between the positivity for serum IgM antibody to hepatitis C virus and the activity of liver disease in patients with chronic hepatitis C virus infection. Serum samples were taken from 10 antibody to hepatitis C virus-positive asymptomatic patients with normal serum ALT levels, from 14 untreated patients with clinically and histologically proven chronic hepatitis C and from 26 patients with clinically and histologically proven chronic hepatitis C assigned to receive recombinant interferon alpha-2a (6 million IU three times a week for 6 mo). Each serum specimen was tested for IgM antibody to hepatitis C virus-associated C100-3 antigen by enzyme-linked immunosorbent assay. Patients were observed for at least 12 mo. All 10 patients with normal ALT values tested negative for IgM antibody to hepatitis C virus. In contrast, 33 of 40 (82%) patients with chronic hepatitis C had IgM antibody to hepatitis C virus, and a positive correlation was seen between the ALT level and the level of IgM antibody to hepatitis C virus (r = 0.803, p less than 0.001). During interferon treatment, ALT levels declined into the normal range in 18 of 26 treated patients (69%) and remained normal after stopping treatment in 8 patients (31%). In untreated patients, in treated patients who did not respond to interferon treatment and in responder patients who relapsed, no significant changes in IgM antibody to hepatitis C virus levels were seen during the study period. In contrast, IgM antibody to hepatitis C virus became undetectable by the end of interferon treatment in seven of eight patients with a sustained response.(ABSTRACT TRUNCATED AT 250 WORDS)
GP deputising service cases are “cause for concern,” says ombudsman
Authors: Singh Debashis
Journal: BMJ (2004)

England's health service ombudsman, Ann Abraham, has expressed alarm at the number of serious cases involving GP deputising services that she has seen in the past six months.

The quality of care, communication with patients, and record keeping in these cases are a “cause for concern,” she says in her latest investigations into complaints against the NHS, published this week

In one case a 32 year old man from London rapidly deteriorated with meningococcal septicaemia as he waited five hours for the on-call GP to visit. Although the GP …
Case of Swallowing of Artificial Teeth and Metallic Plate: With Observations on Similar Accidents
Authors: S. S. Alison
Journal: BMJ (1852)

In the mucous cellular and cutaneous tissues this remark especially holds good; and even in the case of the pulmonaryorgans, which of all others might be supposed to be the least susceptible of such actions, it has been surmised, upon very strong grounds, that not only is vascular disease thus removable, but that even extensive solutions of continuity and cavities have been healed by the efforts of the con- stitution, when these have been properly supported.Why then should it be assumed that the uterine organs are incapable of the same reparative actions?I do not, as I have observed, wish to disparage the utility of topical treatment within certain limits; but I affirm, that it is an error to suppose that uterine derangement, which has sprung, as it were, out of a disordered state of the general healtb, or which is perpetuated by it, can be successfully treated by local measures, whilst its constitutional origin or cause is overlooked.Some, indeed, of the
Neocytolysis on Descent from Altitude: A Newly Recognized Mechanism for the Control of Red Cell Mass
Authors: Lawrence Rice, Wilson Ruiz, Theda Driscoll, Carl E. Whitley, Rosario Tapia, David L. Hachey, Gustavo F. Gonzales, Clarence P. Alfrey
Journal: Annals of Internal Medicine (2001)

Studies of space-flight anemia have uncovered a physiologic process, neocytolysis, by which young red blood cells are selectively hemolyzed, allowing rapid adaptation when red cell mass is excessive for a new environment.1) To confirm that neocytolysis occurs in another situation of acute plethora-when high-altitude dwellers with polycythemia descend to sea level; and 2) to clarify the role of erythropoietin suppression.Prospective observational and interventional study.Cerro de Pasco (4380 m) and Lima (sea level), Peru.Nine volunteers with polycythemia.Volunteers were transported to sea level; three received low-dose erythropoietin.Changes in red cell mass, hematocrit, hemoglobin concentration, reticulocyte count, ferritin level, serum erythropoietin, and enrichment of administered(13)C in heme.In six participants, red cell mass decreased by 7% to 10% within a few days of descent; this decrease was mirrored by a rapid increase in serum ferritin level. Reticulocyte production did not decrease, a finding that establishes a hemolytic mechanism.(13)C changes in circulating heme were consistent with hemolysis of young cells. Erythropoietin was suppressed, and administration of exogenous erythropoietin prevented the changes in red cell mass, serum ferritin level, and(13)C-heme.Neocytolysis and the role of erythropoietin are confirmed in persons with polycythemia who descend from high altitude. This may have implications that extend beyond space and altitude medicine to renal disease and other situations of erythropoietin suppression, hemolysis, and polycythemia.
FDA's Proposed Strategy on Reuse of Single-Use Devices
Authors: Jane E. Henney
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pericarditis after Acute Myocardial Infarction
Authors: U. Thadani, M. P. Chopra, C. P. Aber, R. W. Portal
Journal: BMJ (1971)

Fifty-two (6.8%) of 779 patients admitted to a coronary monitoring unit with acute myocardial infarction developed a pericardial friction rub. A diagnosis of postmyocardial infarction syndrome was made in three of these.The course of the 52 patients with pericarditis was compared with that of a consecutive series of 100 patients without pericarditis. As a group those with pericarditis manifested a longer period of pyrexia, a greater rise in serum enzymes, and a higher incidence of major arrhythmias and of radiological pulmonary oedema. The Peel prognostic index, however, did not differ significantly in the two groups. The hospital mortality of the pericarditis group was not significantly different from that of the 727 non-pericarditis patients. No specially adverse features were found in a follow-up of the pericarditis group.Though the presence of a pericardial rub in the first few days after a myocardial infarction may be a sign of extensive myocardial damage and is associated with a relatively high incidence of ventricular fibrillation, it does not appear to influence the hospital mortality of patients treated in a monitoring unit.
Cancer Control Efforts Reach Out to “Culturally Isolated” Groups
Authors: Lou Fintor
Journal: JNCI Journal of the National Cancer Institute (1998)

ing their way onto the Internet at health and discovery sites, such as Discovery Online, ABC.com, msNBC, and OnHealth.com.But in the new and unregulated world of the Internet, the quality of coverage is variable."Online reporting is very much in its frontier stages," said Watson, whose Discovery Channel Online site has 100,000 hits daily."There is a lot of room to grow and mature.But it is a very exciting time because I think the Internet is a great place to tell science stories because you can use other media to help explain what can be really complicated.It also has the space to do it." -Bob Kuska Complexities of p53It is one of those oft-repeated facto ids at scientific meetings.The tumor suppressor gene p53 is mutated in about half of all cancers, making it the most frequent target for tumor predisposing mutation.But there is another factoid that might be worth mentioning also.According to the latest release from the p53 Mutation Database, operated by the International Agency for Research on Cancer in Lyon, France, scientists have published on more than 9,300 distinct mutations in p53 since the gene was isolated in 1986.p53 has a coding sequence that stretches about 20,000 bases, or units of DNA, and encodes a protein that is 393 amino acids long.