tbuckley/cabot-search huggingface dataset:
A RATIONAL TREATMENT OF DIPHTHERIA WITH OR WITHOUT ANTITOXIN.
Authors: EMERSON M. SUTTON
Journal: JAMA (1897)

or little) that she would be predisposed to trouble of this kind and that the danger of a second attack would be great.I have been unable to find anything in the text-books that I possess (and they are some of the best) bearing upon this subject.About one year after Mrs. A.'s first illness her husband consulted me, wish- ing to know what the chances were for his wife to again suffer from convulsions, if she should again become pregnant.I told him that the chances were very great, and that a second attack might prove fatal, but it seems that I was mistaken.
Wisconsin Medicine: Historical Perspectives
Authors: Dean M. Connors
Journal: JAMA (1981)

Wisconsin, unlike most of its neighboring midwestern states, lacks a standard comprehensive state medical history.  Such a deficiency is hard to understand. Wisconsin has been a hotbed of regional history since Lyman Draper, soon after Wisconsin became a state, put together a small group of books and primary documents—the forerunner of the massive collection of the State Historical Society. Frederick Jackson Turner, continuing this strong tradition, formulated the famous frontier theory at the University of Wisconsin in the late 19th century, and many of his followers have since carried on a high standard of historical scholarship. The University of Wisconsin Medical School at Madison early in its career boasted a faculty including Charles Bardeen, William Snow Miller, and William S. Middleton, who spearheaded the development of an important collection of primary sources in medical history housed in the University Medical School Library in Madison. Members of this group and their
STRUCTURES RESEMBLING FUSEAUX IN A CASE OF RINGWORM OF THE SCALP DUE TO MICROSPORUM CANLS BODIN AND MICROSPORUM AUDOUINI GRUBY.
Authors: GEOFFREY DANIELS
Journal: British Journal of Dermatology (1953)

Journal Article STRUCTURES RESEMBLING FUSEAUX IN A CASE OF RINGWORM OF THE SCALP DUE TO MICROSPORUM CANLS BODIN AND MICROSPORUM AUDOUINI GRUBY. Get access GEOFFREY DANIELS GEOFFREY DANIELS Department of Cryptogamic Botany, University of Manchester Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 65, Issue 3, 1 March 1953, Pages 95–98, https://doi.org/10.1111/j.1365-2133.1953.tb13739.x Published: 01 March 1953
Differential responses of the right ventricle to abnormal loading conditions in mice: pressure vs. volume load
Authors: Beatrijs Bartelds, Marinus A. Borgdorff, Annemiek Smit‐van Oosten, Janny Takens, Bibiche Boersma, Marcel G. Nederhoff, Nynke J. Elzenga, Wiek H. van Gilst, Leon J. De Windt, Rolf M.F. Berger
Journal: European Journal of Heart Failure (2011)
Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney
Authors: Anja Schramme, Mohamed Sadek Abdel-Bakky, Paul Gutwein, Nicholas Obermüller, Patrick C. Baer, Ingeborg A. Hauser, Andreas Ludwig, Stefan Gauer, Liliana Schäfer, Ewelina Sobkowiak, Peter Altevogt, Michael Koziolek, Eva Kiss, Hermann-Josef Gröne, Ritva Tikkanen, Itamar Goren, Heinfried Radeke, Josef Pfeilschifter
Journal: Kidney International (2008)
Antigen receptor–mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
Authors: Cheryl A. Doughty, Blair F. Bleiman, Dean J. Wagner, Fay J. Dufort, Jennifer M. Mataraza, Mary F. Roberts, Thomas C. Chiles
Journal: Blood (2006)
Alcohol dehydrogenase 3∗1 genotype is associated with hepatocellular carcinoma in alcohol-induced liver cirrhosis
Authors: F. Stickel, M. Benesova, H.K. Seitz, I. Zuber-Jerger, C. Hellerbrand, M. Frieser, W.H. Caselmann, H.E. Blum, E.G. Hahn, D. Schuppan
Journal: Journal of Hepatology (2003)
Increased single strand breaks in DNA of lymphocytes from diabetic subjects.
Authors: M Lorenzi, D F Montisano, S Toledo, H C Wong
Journal: Journal of Clinical Investigation (1987)

Certain aspects of the chronic complications of diabetes suggest that, with time, the abnormal metabolic milieu leads to irreversible changes in some cell populations. Since we have previously observed that high glucose concentrations induce an increase in single strand breaks in the DNA of cultured human endothelial cells, we have investigated whether the same abnormality occurs in cells derived from the in vivo diabetic environment. Peripheral blood lymphocytes obtained from 21 type I diabetic patients and age- and sex-matched controls were tested for rate of unwinding in alkali (a measure of DNA single strand breaks). The patients were subdivided into two groups on the basis of glycohemoglobin values above or below 9%. The group with glycohemoglobin values of 12.9 +/- 2.4% (mean +/- SD), but not the group with glycohemoglobin values of 7.4 +/- 1.5%, showed accelerated unwinding of lymphocyte DNA when compared to controls (P less than 0.01). These studies suggest that poorly controlled diabetes may result in DNA lesions, whose impact on long-term complications deserves to be investigated.
Trades Unionism Among Hospital Attendants.
Authors: J. T. Wilson
Journal: JAMA (1904)

Sherman, Texas, Jan. 6, 1904. <h3>To the Editor:</h3> —InThe Journal, January 2, are an editorial, "Trades Unionism Among Hospital Attendants," and a letter from Dr. V. H. Podstata, entitled "Trades Unionism Among Asylum Employes," a subject of more than ordinary importance. The statement of Dr. Podstata: "It is a well-known fact that the attendants and nurses, as well as other employes at Dunning, are under the protection of civil service, the protection being so strong as to absolutely prevent me from either hiring or discharging an employe," is a startling revelation. The forming of a union by the attendants and employes "organized on the same basis as a regular labor organization" is ominous. Hospitals for the insane can not be successfully conducted without a proper organization of officers and employes, all working together under an established set of rules. The superintendent, being responsible for the management, can not have
Decreased Receptor Binding of Biologically Inactive Thyrotropin in Central Hypothyroidism
Authors: Paolo Beck-Peccoz, Sania Amr, M. Margarida Menezes-Ferreira, Giovanni Faglia, Bruce D. Weintraub
Journal: New England Journal of Medicine (1985)

Previous studies have suggested that certain cases of idiopathic central hypothyroidism of hypothalamic origin may result from the secretion of biologically inactive thyrotropin. To investigate this possibility and to define the mechanism of defective hormone action, we measured the adenylate cyclase-stimulating bioactivity (B) and receptor-binding (R) activity of purified immunoreactive serum thyrotropin (I) from seven patients with hypothalamic hypothyroidism. We found a strikingly decreased R/I ratio (less than 0.15) in patients as compared with controls (0.6 to 2.7) and a similarly decreased B/I ratio (less than 0.2 vs 2.8 to 5.6). After acute injection of thyrotropin-releasing hormone (TRH, 200 micrograms intravenously), the R/I ratio increased in two of three patients, but the B/I ratio became normal in only one. After administration of TRH for 20 to 30 days, an increase in immunoreactive serum thyrotropin was observed in all patients. Moreover, both ratios returned to normal in all but one patient, who had apparent desensitization. The increase in the amount and bioactivity of secreted thyrotropin after long-term TRH therapy resulted in enhanced secretion of serum thyroid hormones in all patients studied. We conclude that in certain cases of hypothalamic hypothyroidism, secreted thyrotropin lacks biologic activity because of impaired binding to its receptor; TRH treatment can correct both defects. These data suggest that TRH regulates not only the secretion of thyrotropin but also its specific molecular and conformational features required for hormone action.
Principles of Critical Care
Authors: Robert W. Goldmann
Journal: JAMA (1993)

<b>Principles of Critical Care: PreTest Self-Assessment and Review</b>, edited by Jesse B. Hall, Gregory A. Schmidt, and Lawrence D. H. Wood, 239 pp, with illus, $38, ISBN 0-07-051984-6, New York, NY, McGraw-Hill Publishing Co, 1991. As the field of critical care medicine has expanded, so too have the number of available texts providing comprehensive review of this multidisciplinary specialty. Having previously reviewed<i>Intensive Care Medicine</i>by Rippe et al (second edition), I appreciated the opportunity to compare these two texts. A number of criticisms of Rippe's text were addressed by this University of Chicago Medical Center—based group. For instance, the index appears to have been expanded and cross-referenced aggressively. In addition, a very nice overview of hyperbaric medicine and a chapter on diving medicine are featured. A detailed section on perioperative transesophageal echocardiography is included with clear pictures of actual images. Representative anatomical models appear next to these screens for
Doctor is accused of giving misleading evidence and exaggerating fees
Authors: C. Dyer
Journal: BMJ (2009)

The General Medical Council has accused a microbiologist of giving misleading evidence as an expert witness in a court case and making a dishonest claim for fees from the Legal Services Commission.

Charles Stewart Goodwin, who at the time was a visiting professor at St George’s Hospital Medical School in London, is accused by the GMC of conduct likely to bring the profession into disrepute, in a hearing that began this week.

The GMC alleges that, …
47 EFFICACY AND SAFETY OF PROTEASE INHIBITORS FOR SEVERE HEPATITIS C RECURRENCE AFTER LIVER TRANSPLANTATION: A FIRST MULTICENTRIC EXPERIENCE
Authors: A. Coilly, B. Roche, D. Botta-Fridlund, V. Leroy, P.G. Pageaux, S.N. Si-Ahmed, T.M. Antonini, D. Samuel, J.-C. Duclos-Vallee
Journal: Journal of Hepatology (2012)
Radium Exposure and Longevity: Not Mutually Exclusive
Authors: Marshall Brucer
Journal: JAMA (1990)

To the Editor.—  Dr Macklis notes that Radiothor addict William J. A. Bailey ... reached the age of 64, an astonishing feat of longevity for one who... consumed more radium water than any living man. 1   Dr Macklis must have heard of Marie Curie. She breathed more radon than any woman and died at 67 years of age, 15 years beyond her cohort's life expectancy. Dr Macklis is at Harvard where a generation ago William Duane became famous: after 8 years of breathing radon, he ran the first somewhat leaky radium-radon source (cow) until he died at 63 years of age. Victor Hess, maker of radon sources, died at 81 years of age, 30 years after his thumb was amputated because of a radium injection. And Friedrich Giesel, who made most of the early commercial radium sources and was the first to have his stratospheric body background measured by Elster and
Methotrexate Therapy for Plasmodium vivax Malaria
Authors: Thomas W. Sheehy
Journal: JAMA (1970)

Among the more promising groups of drugs undergoing evaluation as antimalarial agents are the folic acid antagonists. These agents destroy plasmodia presumably by competitive inhibition of dihydrofolate reductase, the enzyme that catalyzes the conversion of dihydrofolic acid to metabolically active tetrahydrofolic acid. This reaction is necessary for nucleic acid synthesis and cell mitosis.<sup>1-3</sup>Pyrimethamine (2, 4-diamino-5-[<i>p</i>- chlorophenyl]- 6 - ethylprimi dine) and chloroguanide (N<sup>1</sup>- [<i>p</i>chlorophenyl]- N<sup>5</sup>- isopropyldiguanide) have been used extensively for malarial chemoprophylaxis and treatment during the past 20 years; only recently they have been recognized as folic acid antagonists. Unfortunately, these agents are too slow acting to be used for treatment of established infections with<i>Plasmodium falciparum</i>. Their use in such cases may lead to a fatal outcome for the patient or to the development of resistant strains.<sup>4</sup> In addition to these observations, the appearance of chloroquine-resistant falciparum malaria in many
The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation
Authors: Tommy E. White, Alberto Brandariz-Nuñez, Jose Carlos Valle-Casuso, Sarah Amie, Laura Anh Nguyen, Baek Kim, Marina Tuzova, Felipe Diaz-Griffero
Journal: Cell Host & Microbe (2013)
Submandibular Uptake on lndium-111 Leukocyte Scans in Children
Authors: SUSAN L. WILLIAMSON, MICHAEL R. WILLIAMSON, JOANNA J. SEIBERT, CHARLES M. BOYD
Journal: Clinical Nuclear Medicine (1987)

Report is made of false-positive localization of In-111 leukocytes in the submandibular gland area in children. Possible mechanisms are discussed, but this may represent a normal finding in children.
Identification of thymocyte progenitors in hemopoietic tissues of the rat. II. Enrichment of functional prothymocytes on the fluorescence-activated cell sorter.
Authors: D L Greiner, I Goldschneider, R W Barton
Journal: The Journal of Experimental Medicine (1982)

A quantitative thymocyte regeneration assay was used to monitor the isolation of functional prothymocytes from rat bone marrow on the FACS. Two prothymocyte subpopulations were tentatively identified on the basis of their relative resistance to dexamethasone. Both populations were comprised of undifferentiated, medium-size cells that displayed large amounts of Thy-1 antigen. Simultaneous sorting of bone marrow cells according to relative low angle light scatter (size) and relative fluorescence intensity for Thy-1 resulted in enrichments of 112-fold and 260-fold, respectively, in prothymocyte activity in untreated and dexamethasone-treated bone marrow. These prothymocyte-enriched cell fractions contained or approximately 75% of total functional prothymocyte activity in bone marrow, and represented 1.1 and 0.35% of total untreated and dexamethasone-treated bone marrow cells. Using these enriched cell fractions, significant thymocyte regeneration is possible with as few as 2 X 10(4) and 1 X 10(4) bone marrow cells, respectively. The possible relationship of these functional prothymocyte subpopulations with CFU-S and with TdT-positive cells is discussed.
Abstract PR1: BRAFV600E remodels the melanocyte transcriptome and induces BLNCR1 to regulate melanoma cell migration
Authors: Ross J. Flockhart, Dan E. Webster, Kun Qu, Nicholas Mascarenhas, Joanna Kovalski, Markus Kretz, Paul A. Khavari
Journal: Cancer Research (2012)

Abstract Aberrations of protein-coding genes are a focus of cancer genomics, however, the impact of oncogenes on expression of the ~50% of transcripts without protein-coding potential, including long non-coding RNAs (lncRNAs), is largely uncharacterized. Activating mutations in the BRAF oncogene are present in 60% of melanomas, 90% of which produce active mutant BRAFV600E. To define the impacts of oncogenic BRAF on the melanocyte transcriptome, massively parallel cDNA sequencing (RNA-Seq) was performed on genetically matched normal human melanocytes with and without BRAFV600E expression. To enhance potential disease relevance by verifying expression of altered genes in BRAF-driven cancer tissue, parallel RNA-Seq was also undertaken on two BRAFV600E-mutant human melanomas. BRAFV600E regulated expression of 1,027 protein-coding transcripts and 39 annotated lncRNAs, as well as 70 un-annotated, potentially novel, intergenic transcripts. Coding potential analysis of these 70 transcripts suggested that most may represent newly identified non-coding RNAs. BRAF-regulated long non-coding RNA 1 (BLNCR1) was identified as a recurrently, highly expressed, previously un-annotated 693 bp transcript on chromosome 9 with a potential functional role in melanoma cell migration. Combining RNA-Seq of oncogene-expressing normal cells with RNA-Seq of their corresponding human cancers may represent a useful approach to discover new oncogene-regulated RNA transcripts of potential clinical relevance to cancer. This abstract is also presented as Poster A11. Citation Format: Ross J. Flockhart, Dan E. Webster, Kun Qu, Nicholas Mascarenhas, Joanna Kovalski, Markus Kretz, Paul A. Khavari. BRAFV600E remodels the melanocyte transcriptome and induces BLNCR1 to regulate melanoma cell migration [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer; 2012 Jan 8-11; Miami Beach, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(2 Suppl):Abstract nr PR1.
Alternative Referent Standards for Cardiac Normality
Authors: ALAN ROZANSKI
Journal: Annals of Internal Medicine (1984)

The radionuclide ventriculographic exercise response was evaluated in three patient populations representing alternative referent standards for cardiac normality: patients with normal coronary arteriograms, healthy volunteers, and uncatheterized patients with a low probability of coronary artery disease. Disease probability was determined by Bayesian analysis of age, sex, symptoms, and the results of cardiac fluoroscopy, exercise electrocardiography, or thallium scintigraphy. A wide range of ventriculographic responses was noted in the 62 catheterized normal patients; 21 (34%) had an abnormal ejection fraction response and 22 (35%) had an abnormal wall motion response. In contrast, the ejection fraction and wall motion responses were normal in the 9 volunteers. In 90 patients (18 catheterized and 72 uncatheterized) who had low disease probability ( < 1%), abnormal responses were rare; the ejection fraction response was abnormal in only 7% and the wall motion response was abnormal in 8%. Thus, these three populations are not equivalent referent standards of normality. Volunteers and patients with low disease probability provide too strict a standard, and their use can overestimate test specificity; catheterized normal patients, on the other hand, provide too lenient a standard, and their use can underestimate test specificity.
THE MINIMUM VITAMIN REQUIREMENTS OF THE L AND H<scp>E</scp>L<scp>A</scp> CELLS IN TISSUE CULTURE, THE PRODUCTION OF SPECIFIC VITAMIN DEFICIENCIES, AND THEIR CURE
Authors: Harry Eagle
Journal: The Journal of Experimental Medicine (1955)

SEVEN VITAMINS HAVE TO DATE PROVED ESSENTIAL FOR THE SURVIVAL AND MULTIPLICATION OF A MOUSE FIBROBLAST (STRAIN L) AND A HUMAN CARCINOMA CELL (STRAIN HELA) IN TISSUE CULTURE: choline, folic acid, nicotinamide, pantothenic acid, pyridoxal, riboflavin, and thiamin. It was necessary to cultivate the cells for 5 to 15 days in a medium lacking the specific vitamin before the deficiency became apparent in the cessation of multiplication and the development of specific cytopathogenic effects. In their early stages these changes could be reversed by the addition of the missing vitamin, an in vitro, "cure" of a vitamin deficiency. The maximally effective concentrations were in the range 10(7) to 10(8) gm. per ml. The probability that additional vitamins not demonstrably essential under the conditions of the present experiments are nevertheless required for survival and growth is discussed in the text.
Specific Effects of Biliopancreatic Diversion on the Major Components of Metabolic Syndrome
Authors: Nicola Scopinaro, Giuseppe Maria Marinari, Giovanni Bruno Camerini, Francesco Saverio Papadia, Gian Franco Adami
Journal: Diabetes Care (2005)

Gastric bypass and biliopancreatic diversion (BPD) are known to have a beneficial effect on glucose metabolism superior to that of the other bariatric operations. Thanks to its excellent weight loss results and to its specific actions, BPD has proven able to guarantee permanent normalization of serum glucose, triglyceride, and cholesterol levels in the vast majority, if not the totality, of operated patients. However, clinical studies on the duration of these effects in large patient populations are still lacking.The files of 312 BPD obese patients with type 2 diabetes operated on from June 1984 to January 1993 were examined. Pre- and postoperative serum glucose, triglyceride, and cholesterol levels, along with arterial pressure measurements, were considered.After BPD, fasting serum glucose concentration fell within normal values in all but two of the operated subjects and remained in the physiological range in all but six up until 10 years. Serum triglyceride and total cholesterol steadily normalized in all subjects with abnormally high preoperative values, and arterial hypertension disappeared in the vast majority of the preoperatively hypertensive patients.BPD proved able to reverse all the major components of the metabolic syndrome in nearly all the operated subjects, with results being strictly maintained over a 10-year follow-up period. This outcome, which far exceeds those following similar weight loss at short or long term obtained by any other means, confirms the existence of specific actions of BPD on the major components of metabolic syndrome.
Reduction of bloodstream infections associated with catheters in paediatric intensive care unit: stepwise approach
Authors: Adnan Bhutta, Craig Gilliam, Michele Honeycutt, Stephen Schexnayder, Jerril Green, Michele Moss, K J S Anand
Journal: BMJ (2007)

Bloodstream infections associated with catheters were the most common nosocomial infections in one paediatric intensive care unit in 1994-7, with rates well above the national average.Clinical data were collected prospectively to assess the rates of infection from 1994 onwards. The high rates in 1994-7 led to the stepwise introduction of interventions over a five year period. At quarterly intervals, prospective data continued to be collected during this period and an additional three year follow-up period.A 292 bed tertiary care children's hospital.We aimed to reduce our infection rates to below the national mean rates for similar units by 2000 (a 25% reduction).A stepwise introduction of interventions designed to reduce infection rates, including maximal barrier precautions, transition to antibiotic impregnated central venous catheters, annual handwashing campaigns, and changing the skin disinfectant from povidone-iodine to chlorhexidine. Effects of change Significant decreases in rates of infection occurred over the intervention period. These were sustained over the three year follow-up. Annual rates decreased from 9.7/1000 days with a central venous catheter in 1997 to 3.0/1000 days in 2005, which translates to a relative risk reduction of 75% (95% confidence interval 35% to 126%), an absolute risk reduction of 6% (2% to 10%), and a number needed to treat of 16 (10 to 35).A stepwise introduction of interventions leading to a greater than threefold reduction in nosocomial infections can be implemented successfully. This requires a multidisciplinary team, support from hospital leadership, ongoing data collection, shared data interpretation, and introduction of evidence based interventions.