tbuckley/cabot-search huggingface dataset:
AB0031 Lack of association between CXCL12 RS501120 polymorphism and cardiovascular disease in spanish patients with rheumatoid arthritis
Authors: R. Lόpez-Mejías, M. García-Bermúdez, C. González-Juanatey, S. Castañeda, J.A. Miranda Filloy, C. Gόmez-Vaquero, B. Fernández, A. Balsa, D. Pascual, R. Blanco, I. González-Alvaro, J. Llorca, J. Martín, M.A. González-Gay
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is an autoimmune inflammatory disease associated with accelerated atherosclerosis [1]. Both a chronic inflammatory response [2]and genetic factors have been implicated in the augmented cardiovascular (CV) mortality observed in these patients. CXCL12 is a chemotactic signal for lymphocytes encoded by the gene <i>CXCL12</i>. The variant polymorphism rs501120 (T&gt;C), located near of <i>CXCL12</i> gene, has been associated with CAD [3]. <h3>Objectives</h3> We aimed to determine the potential role of <i>CXCL12</i> rs501120 polymorphism in the risk of CV disease in a large cohort of RA patients. <h3>Methods</h3> 1321 Spanish patients with RA were assessed. A subgroup of patients without CV events was also studied to determine the presence of subclinical atherosclerosis by ultrasonography (brachial flow-mediated endothelium-dependent vasodilatation and carotid intima-media wall thickness) <h3>Results</h3> No significant differences in genotypic and allelic frequencies between RA patients with and without CV events were observed. It was also the case when values of surrogate markers of atherosclerosis were assessed according to <i>CXCL12</i> rs501120 genotype frequencies. <h3>Conclusions</h3> In conclusion, our results do not confirm an association of <i>CXCL12</i> rs501120 polymorphism with atherosclerosis neither CV disease in RA. This study was supported by two grants from "Fondo de Investigaciones Sanitarias" PI06-0024 and PI09/007/48 (Spain) and it was partially supported by RETICS Program, RD08/0075 (RIER) from "Instituto de Salud Carlos III" (ISCIII). <h3>References</h3> Gonzalez-Gay MA, Gonzalez-Juanatey C, Martin J. Rheumatoid arthritis: a disease associated with accelerated atherogenesis. Semin Arthritis Rheum 2005;35:8-17 Gonzalez-Gay MA, Gonzalez-Juanatey C, Lopez-Diaz MJ, Pineiro A, Garcia-Porrua C, Miranda-Filloy JA et al. HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis. Arthritis Rheum 2007;57:125-32 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78 <h3>Disclosure of Interest</h3> None Declared
1049 PHASE 2 RANDOMIZED, DOUBLE-BLIND, PLACEBO- CONTROLLED STUDY OF NITAZOXANIDE PLUS PEGINTERFERON AND RIBAVIRIN IN HCV GENOTYPE 1 PATIENTS: INTERIM ANALYSIS SHOWS INCREASE IN EVR
Authors: B. Bacon, M. Shiffman, J. Lim, A. Berman, V. Rustgi, E. Keeffe
Journal: Journal of Hepatology (2009)
Multiple-dose pharmacokinetics of rufloxacin in patients with cirrhosis
Authors: David R. Triger, Fernando Granai, Jocelyn Woodcock, Richard Wise, Bruno P. Imbimbo
Journal: Hepatology (1993)

The multiple-dose pharmacokinetics of rufloxacin were investigated in 13 patients with biopsy-proven cirrhosis and in 5 healthy controls. Rufloxacin was administered once a day for 5 consecutive days, starting with a loading dose of 400 mg on day 1 and 200 mg on the subsequent days. Plasma and urinary drug concentrations were determined by high-performance liquid chromatography and a microbiological assay. A one-compartment model applied to the high-performance liquid chromatography data was used to calculate the pharmacokinetic parameters of rufloxacin. In the controls rufloxacin had a low plasma clearance (41 ± 4 ml/min, mean ± S.E.M.), a long half-life (30.1 ± 3.9 hr), a large area under the plasma concentration vs. time curve (171 ± 18 μg · hr/ml) and a low renal clearance (18 ± 2 ml/min). No appreciable differences were observed in the pharmacokinetic parameters between patients with various degrees of liverfunction impairment (modified Child-Pugh score ranging from 5 to 13). In these patients plasma clearance was slightly reduced (−32%), but this decrease was caused by a marked reduction in renal clearance (−65%) rather than nonrenal clearance, which remained unchanged (22 ml/min in cirrhotic patients vs. 23 ml/min in controls). A significant (p &lt; 0.01) correlation was found between creatinine clearance and both rufloxacin renal clearance (r = 0.769) and rufloxacin plasma clearance (r = 0.681). The elimination half-life and the area under the plasma concentration vs. time curve were moderately increased in cirrhotic patients (+33% and +26%, respectively). These findings indicate that factors related to declining renal function, rather than liver impairment itself, may be the prime cause in determining alterations in the pharmacokinetic parameters in cirrhotic patients. When these patients have normal renal function, no dose adjustment is needed during oral rufloxacin treatment. (HEPATOLOGY 1993;18:847-852).
Laryngeal Edema Following Anesthesia
Authors: Ronald L. Scott
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Laryngeal edema following anesthesia is usually observed in very young patients and is an uncommon complication of intubation anesthesia even in children under the age of 1 year. Goddard et al while investigating betamethasone as a prophylactic against this condition found 19 out of 454 in their control group and 13 out of 471 in their experimental group who had any discernable degree of laryngeal narrowing. Only one patient had sufficient narrowing to show intercostal retraction. A recent case of laryngeal edema in an adult followed short anesthesia with endotracheal intubation in a patient with dermographism. <h3>Report of a Case.—</h3> A 44-year-old white man had a sore throat in January 1970, which was associated with the swelling of the left side of the neck. He was treated with penicillin, and then ampicillin subsequently for six weeks prior to surgery without complete resolution of this mass. Because of
Increased urine neopterin levels in psoriasis
Authors: C.C. HARLAND, R.P. WHITAKER, J.L. BARRON, C.A. HOLDEN
Journal: British Journal of Dermatology (1992)

The production of neopterin closely reflects activation of T-lymphocyte-mediated immunity. Oxidized and reduced forms of urine neopterin were measured by reversed-phase ion-pair high-performance liquid chromatography in patients with moderate to severe chronic plaque psoriasis (n= 14), and in a heterogeneous group of patients (n= 14) with cutaneous T-cell malignancies (CTCM). Results were compared with healthy non-psoriatic control subjects (n= 30). Neopterin levels were repeated after a course of ultraviolet B therapy (UVB) plus topical tar or dithranol, or photochemotherapy (PUVA), in 12 psoriatic patients. Fully oxidized urine neopterin levels and neopterin/creatinine ratios were significantly elevated in the psoriatic group compared with controls (P < 0·002, P < 0·05) but not in the CTCM group. Both neopterin and its creatinine ratio were significantly reduced by treatment (P < 0·05, P < 0·01). Psoriasis area and severity index scores (PASI) correlated strongly with urine neopterin levels (P < 0·001). These findings indicate that urine neopterin concentrations may be a marker of psoriatic disease activity, and further support the importance of activated T lymphocytes in the pathogenesis of psoriasis.
Pathogenesis of Fever in Man
Authors: Howard L. Bleich, Emily S. Boro, Charles A. Dinarello, Sheldon M. Wolff
Journal: New England Journal of Medicine (1978)

FOR centuries before the introduction of the thermometer, fever was a well recognized sign of disease. During the Age of Pericles (ca. 450 B.C.) physicians accurately described the physical findings associated with the fevers of typhoid and other infections. However, only during the past three decades has the mechanism by which disease causes a rise in body temperature begun to be clarified. Studies in animals and in human beings have expanded knowledge of the pathogenesis of fever, and, more recently, information has been obtained at the molecular level. This report reviews established concepts and presents newer information on the pathogenesis . . .
Comparison of Apraclonidine and Timolol in Chronic Open-angle Glaucoma
Authors: Suryanarayanan Nagasubramanian, Roger A. Hitchings, Philippe Demailly, Michèle Chuniaud, Mario R. Pannarale, José Pecori-Giraldi, Richard Stodtmeister, David G. Parsons
Journal: Ophthalmology (1993)
Pioglitazone, a PPAR? agonist, restores endothelial function in aorta of streptozotocin-induced diabetic rats
Authors: J MAJITHIYA, A PARAMAR, R BALARAMAN
Journal: Cardiovascular Research (2005)

Objective: To study the effect of pioglitazone (a PPAR gamma agonist) treatment on blood pressure, endothelial function, and oxidative stress in streptozotocin (STZ)-induced diabetic rats.
Improving the chances of successful research funding.
Authors: M Turner-Warwick
Journal: Thorax (1986)

Improving the chances of successful research fundingThe fact that symptoms of lung disease are so ubiquitous seems to imply to some that respiratory medicine is not a specialty field deserving dedicated support in its own right.Even today it is not uncom- mon to hear the view expressed that respiratory med- icine ceased to have importance when that sometimes heroic infectious disease tuberculosis was conquered.When this stand is challenged, the further riposte is that only lung cancer and chronic bronchitis remain: it is maintained that both are intractable and of no public concern since they are the sole responsibility of the unheeding patient who persists in smoking cigarettes despite repeated health warnings from the Gov- ernment (and the Royal College of Physicians).This view, of course, expresses only an ignorance of the facts.Nevertheless, such a concept of respiratory medicine does not augur well either for those trying to raise money or for those who need to convince their peers in other specialties of the opportunities in and importance of research on lung disease.Currently there appears to be a vicious circle, where lack of recognition of the importance of respiratory medicine to the community is leading to lack of research funding.This in turn reduces the number of individuals working in this area, which further reduces public awareness of the need.This downward spiral must be reversed.
Hyponatremia in the Urologic Patient
Authors: Edward L. Peirson
Journal: New England Journal of Medicine (1955)

DURING the past ten years the danger of giving patients (particularly those with impaired cardiac function) too much sodium has frequently been stressed. However, the opposite danger of hyponatremia, or a low sodium level, has received very little emphasis and for this reason has often not been recognized. Time does not allow a general discussion of electrolyte balance, which has been more than adequately covered by numerous books and papers on the subject. Actually, this great volume of work has made the subject seem unduly complex. In this purely clinical paper I wish to emphasize the facts that low sodium . . .
Expectoration of Bronchogenic Tumor Tissue
Authors: William H. Kern
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Dr Allan R. Goldstein reports an interesting case of expectoration of bronchogenic tumor tissue (236:1271, 1976) and correctly points out that this is a rare occurrence. This phenomenon has, however, been reported earlier (<i>J Thorac Cardiovasc Surg</i>46:393-403, 1963). Our case was that of a 68-year-old woman who, during a nine-month period, repeatedly expectorated cylindrical, sausage-shaped, rubbery portions of polypoid tumor measuring from 2.5 to 6 cm in length and up to 1.5 cm in diameter. Repeated bronchoscopic studies were required before the base of this lesion, a 1-cm tumor in the right lower lobe bronchus, could be localized and a lobectomy performed. The polypoid tumor was invasive and of a mixed bronchioloalveolar, squamous, and spindle-cell type. In spite of the small size of the lesion, the patient died of cerebral metastases seven months after resection. In view of the presence of malignant cells in the sputum
Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
Authors: Zhi-Zhou Shi, Li Shang, Yan-Yi Jiang, Jia-Jie Hao, Yu Zhang, Tong-Tong Zhang, De-Chen Lin, Shu-Guang Liu, Bo-Shi Wang, Ting Gong, Qi-Min Zhan, Ming-Rong Wang
Journal: Clinical Cancer Research (2013)

Our aim was to identify frequent genomic aberrations in both esophageal squamous cell carcinoma (ESCC) and esophageal dysplasia and to discover important copy number-driving genes and microRNAs (miRNA) in ESCC.We conducted array-based comparative genomic hybridization (array CGH) on 59 ESCC resection samples and 16 dysplasia biopsy samples. Expression of genes at 11q13.3 was analyzed by real-time PCR (RT-PCR) and immunohistochemistry (IHC). Integrated analysis was conducted to identify genes or miRNAs with copy number-expression correlations.Array CGH identified 11 amplifications and eight homozygous deletions in ESCC. Integrated analysis of array CGH data with matched gene expression microarray data showed that 90 overexpressed genes and 24 underexpressed genes were consistent with DNA copy number changes, including 12 copy number-driving miRNAs. In esophageal dysplasia, six gains, four losses, 12 amplifications, and four homozygous deletions were detected. Amplifications of 7p11.2 and 11q13.2-11q13.3 (CCND1) and homozygous deletion at 9p21.3 (CDKN2A) were consistent genomic changes in both dysplasia and carcinoma. ANO1 at 11q13.3 was overexpressed at the mRNA and protein levels in tumors, and higher mRNA expression was correlated with the copy number increase. In particular, ANO1 expression was elevated in moderate dysplasia compared with normal esophageal epithelium. IHC revealed that ANO1 overexpression was positively correlated with lymph node metastasis and advanced clinical stage. Knockdown of ANO1 significantly inhibited the proliferation of KYSE30 and KYSE510 cells.Copy number aberrations in both esophageal dysplasia and ESCC may be useful as potential biomarkers for early detection. In addition, ANO1 may be a candidate target gene in esophageal tumorigenesis.
RELATIONSHIP BETWEEN FRONTAL PLANE KNEE ANGLE AND SUBJECTIVE ASSESSMENT OF KNEE CONTROL DURING A SINGLE-LEG SQUAT
Authors: A Räisänen, K Pasanen, J Parkkari
Journal: British Journal of Sports Medicine (2014)

Background Knee valgus angles have been identified as important predictors of ACL injury risk. To screen for athletes with poor dynamic knee stability simple field tests are needed. Objective Purpose of this study was to find out if the subjective assessment of knee control in the single-leg squat task correlates with the two-dimensional video analysis of frontal plane knee angles. Design Single-measure. Setting The study took place at the UKK Institute, in Tampere, Finland from April 2011 to May 2013. Participants 480 floorball, basketball, ice-hockey and volleyball players, out of which 283 were females (mean age 17 years, SD 4) and 197 were males (mean age 16 years, SD 2) . Risk factor assessment The subject's ability to control the knee during the single-leg squat was assessed by an observer from the front side of the subject. The subjects squatted down to a 90 degree knee flexion angle. A scale from 0 to 2, where 0 equals “good performance” and 2 “poor performance”, was used. Frontal plane knee angles were calculated for each valid trial from the video image. Main outcome measurements Subjective assessment of knee control, mean frontal plane knee angle. Results The mean frontal plane knee angles were different among subjects rated “good performance” (right 2°, SD 7; left 1°, SD 7), “reduced performance” (right 10°, SD 9; left 8°, SD 7) or “poor performance” (right 20°, SD 9; left 18°, SD 9). These differences were statistically significant (P&lt;.001) for right and left leg. Conclusions This study suggests that the subjective assessment on knee control during a single-leg squat task is a suitable tool to screen for athletes with reduced knee control. In future, studies it is necessary to study if the athletes identified having poor or reduced control are in greater risk of knee injury.
Na,K-ATPase in isolated nephron segments in rats with experimental heart failure.
Authors: H Wald, P Scherzer, M M Popovtzer
Journal: Circulation Research (1991)

To characterize renal transport of Na+ in heart failure, urinary Na+ excretion (UNaV), aldosterone levels, and Na,K-ATPase activity in isolated nephron segments were determined in three groups: control rats, rats with heart failure and moderate sodium retention, and rats with heart failure and severe sodium retention. Heart failure was induced by a fistula between the aorta and vena cava. For the control group, UNaV was 0.66 +/- 0.04 (mean +/- SEM) mueq/min, and aldosterone was 18.4 +/- 3.5 ng%. Na,K-ATPase activity (in 10(-11) mol/mm/min) was 28.4 +/- 1.1 in the proximal convoluted tubule, 23.3 +/- 1.0 in the proximal straight tubule, 37.4 +/- 1.9 in the medullary thick ascending limb, 40.2 +/- 1.9 in the cortical thick ascending limb, 43.2 +/- 2.2 in the distal convoluted tubule, and 20.5 +/- 0.9 in the cortical collecting duct. For the group with moderate heart failure, UNaV was 0.35 +/- 0.02 (p less than 0.001 versus control), and aldosterone was 15.9 +/- 4.4 (p = NS versus control). Na,K-ATPase activity was unchanged in the proximal convoluted tubule, proximal straight tubule, medullary thick ascending limb, and cortical collecting duct, but it increased in the cortical thick ascending limb to 57.7 +/- 3.1 (p less than 0.001 versus control) and decreased in the distal convoluted tubule to 35.3 +/- 1.2 (p less than 0.005 versus control). For the group with severe heart failure, UNaV was 0.029 +/- 0.016 (p less than 0.001 versus control), and aldosterone was 186.0 +/- 14.8 (p less than 0.001 versus control).(ABSTRACT TRUNCATED AT 250 WORDS)
Microneedle Electrodes Toward an Amperometric Glucose‐Sensing Smart Patch
Authors: Michael A. Invernale, Benjamin C. Tang, Royce L. York, Long Le, David Yupeng Hou, Daniel G. Anderson
Journal: Advanced Healthcare Materials (2013)

Here, efforts toward the development of a microneedle-based glucose sensor or "smart patch" for intradermal glucose sensing are described. Metallic microneedle array electrodes, conducting polymers, and glucose oxidase form the sensor platform. This work represents the first steps toward the development of painless, transdermal-sensing devices for continuous glucose monitoring As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Influence of dietary fat on the pharmacodynamics of propafenone in isolated, perfused rabbit hearts.
Authors: A M Gillis, R Keashly, P A Watson, H J Mathison, H G Parsons
Journal: Circulation (1992)

The fatty acid composition of the phospholipids in sarcolemma may significantly influence cell membrane functions. We evaluated the effects of dietary fat on the pharmacodynamics of the antiarrhythmic drug propafenone in isolated, perfused rabbit hearts.Three groups of weanling rabbits (n = 9 each group) were fed diets of 10% wt/wt lard, fish oil, or safflower oil for 40 days. Differences in electrophysiological variables were assessed at baseline and during propafenone perfusion. Myocardial concentration-effect relations were determined by plotting electrophysiological effects versus coronary sinus propafenone concentrations. The linoleic acid content of isolated sarcolemma was higher in the safflower group (33.4 +/- 11.4%) than in the lard (13.4 +/- 2.3%, p less than 0.01) and fish oil (8.5 +/- 1.4%, p less than 0.01) groups, whereas the omega-3 fatty acid content was higher in the fish oil group (p less than 0.01). During propafenone perfusion, greater changes in ventricular conduction time were observed in the lard group (22 +/- 11 msec) than in the safflower oil group (10 +/- 7 msec, p less than 0.05), whereas changes in ventricular conduction time in the fish oil group (16 +/- 7 msec) were intermediate between the lard and safflower oil groups. The slopes of the linear myocardial concentration-effect relations describing changes in QRS duration were steeper in the lard group (0.22 +/- 0.07 msec/micrograms/ml) than in the safflower oil group (0.13 +/- 0.04 msec/micrograms/ml, p less than 0.01) but not in the fish oil group (0.17 +/- 0.08 msec/microgram/ml, p = NS). Strength-interval curves were similar at baseline in all three groups. During propafenone perfusion, the threshold current was increased significantly at long coupling intervals (250-380 msec) in the lard group (1.8 +/- 1.0 mA) compared with the safflower oil group (0.8 +/- 0.6 mA, p less than 0.05) but not compared with the fish oil group (1.2 +/- 0.6 mA, p = NS).Dietary fat significantly alters the fatty acid composition of the phospholipids in sarcolemma. Propafenone effects on ventricular conduction time and ventricular excitability are significantly influenced by the type of dietary fat.
Glycolytic activity and enhancement of serotonin uptake by endothelial cells exposed to hypoxia/anoxia.
Authors: S L Lee, B L Fanburg
Journal: Circulation Research (1987)

Serotonin (5-HT) uptake by bovine pulmonary artery endothelial cells in culture was stimulated several fold by exposure of cells for 24 hours to 0-3% O2. The cells appeared normal morphologically, excluded trypan blue dye, showed normal levels of release of lactate dehydrogenase, and contained normal amounts of adenosine triphosphate (ATP). Incubation of cells with iodoacetate (3-5 microM), an inhibitor of glycolytic metabolism, prevented the stimulation of 5-HT uptake but did not impair cellular proliferation. A similar, but less pronounced, effect was produced by 1 mM deoxyglucose. On the other hand, the mitochondrial inhibitors antimycin A, sodium azide, potassium cyanide, and 2,4-dinitrophenol inhibited cellular replication similar to the effect of anoxia but did not alter the stimulation of 5-HT uptake. 5-HT uptake correlated strongly with lactate production by the cells exposed to anoxia (r = 0.98). We conclude that stimulation of 5-HT uptake by prolonged exposure of the endothelial cell to hypoxia/anoxia causes alteration of a membrane function (serotonin transport) of the endothelial cell. This alteration is associated with enhanced glycolytic activity of the cell during exposure to hypoxia. The mechanism for translation of enhanced glycolysis to later stimulation of 5-HT uptake remains to be determined. Endothelial cellular replication is dependent on aerobic metabolism.