Antimicrobial Monotherapy: A 1984 Phoenix
Authors: JAY P. SANFORD
Journal: Annals of Internal Medicine (1984)

Editorials1 October 1984Antimicrobial Monotherapy: A 1984 PhoenixJAY P. SANFORD, M.D.JAY P. SANFORD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-4-557 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction of streptomycin in 1946 opened an era of debate about single versus combined therapy. Since then, acceptable indications for using two or more anti-microbial agents simultaneously have been defined, including initial use in serious suspected bacterial infections before precise bacteriologic identification of causative agents is obtained; anticipated synergism between two agents against an organism; management of polymicrobial infections caused by organisms with differing antimicrobial susceptibilities; prevention of the development of bacterial resistance; and reduction in dosage of a potentially toxic drug. In the 20 years since the introduction of gentamicin, near universal agreement has developed that an aminoglycoside...References1. GILBERTSANFORD DJ. A clinical perspective of antibiotic therapy: aminoglycosides vs. broad-spectrum β-lactams. Rev Infect Dis. 1983;5(suppl 2):S211-398. CrossrefGoogle Scholar2. SMITHAMBINDERLIPSKY CRJ. Cefotaxime versus nafcillin plus tobramycin for serious bacterial infections: a randomized, double-blind trial. Ann Intern Med. 1984;101:469-77. LinkGoogle Scholar3. PIZZOROBICHAUDGILLWITEBSKY PKFF. Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am J Med. 1982;72:101-11. CrossrefMedlineGoogle Scholar4. SCHIMPFFGAYAKLASTERSKYTATTERSALLZINNER SHJMS. Three antibiotic regimens in the treatment of infection in febrile granulo-cytopenic patients with cancer: the EORTC international antimicrobial therapy group. J Infect Dis. 1978;137:14-29. CrossrefMedlineGoogle Scholar5. BRYANT R. Effect of the suppurative environment on antibiotic activity. In: ROOT RK, SANDE MA, eds. New Dimensions in Antimicrobial Therapy. New York: Churchill-Livingstone. 1984:313-37. Google Scholar6. PENNINGTONJOHNSONPLATT JCR. Third-generation cephalosporins in the treatment of pneumonia due to Pseudomonas aeruginosa in guinea pigs. J Infect Dis. 1982;146:567. CrossrefMedlineGoogle Scholar7. RUSNAKDRAKEHACKBARTHSANDE MTCM. Single versus combination antibiotic therapy for pneumonia due to Pseudomonas aeruginosa in neutropenic guinea pigs. J Infect Dis. 1984;149:980-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Uniformed Services University of the Health Sciences Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAcute Enteric Sepsis: Bacteriology and Antibiotic CoverGram-negative bacillary infectionsChoosing antimicrobials 1 October 1984Volume 101, Issue 4Page: 557-558KeywordsAntibiotic resistanceAntimicrobial resistanceAntimicrobialsDrugsStreptomycin Issue Published: 1 October 1984 PDF DownloadLoading ...