Efficacy and Safety of Inhaled Insulin Therapy
Authors: Balavenkatesh Kanna, Neeti Mishra
Journal: Annals of Internal Medicine (2006)

Letters4 April 2006Efficacy and Safety of Inhaled Insulin TherapyBalavenkatesh Kanna, MD, MPH and Neeti Mishra, MDBalavenkatesh Kanna, MD, MPHFrom Weill Medical College of Cornell University, New York, NY 10021.Search for more papers by this author and Neeti Mishra, MDFrom Weill Medical College of Cornell University, New York, NY 10021.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-7-200604040-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The study by Rosenstock and colleagues (1) included patients with type 2 diabetes who had a wide range of body mass index (BMI) measurements. In patients with type 2 diabetes, obesity is associated with poor treatment response to insulin (2). Because higher BMI may be a potential confounder of the study's primary outcome (change in hemoglobin A1c level from baseline), we recommend an analysis that is based on predefined BMI strata to distinguish the effects of inhaled insulin among patients of various body types. In addition, analysis of the confounding effects of dietary restriction and exercise regimens ...References1. Rosenstock J, Zinman B, Murphy LJ, Clement SC, Moore P, Bowering CK, et al. Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes: a randomized, controlled trial. Ann Intern Med. 2005;143:549-58. [PMID: 16230721] LinkGoogle Scholar2. Yki-Jarvinen H, Ryysy L, Kauppila M, Kujansuu E, Lahti J, Marjanen T, et al. Effect of obesity on the response to insulin therapy in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1997;82:4037-43. [PMID: 9398709] CrossrefMedlineGoogle Scholar3. Juni P, Altman DG, Egger M. Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ. 2001;323:42-6. [PMID: 11440947] CrossrefMedlineGoogle Scholar4. Osborne JW, Overbay A. The power of outliers (and why researchers should always check for them). Accessed at PAREonline.net/getvn.asp?v=9&n=6 on 2 March 2006. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Weill Medical College of Cornell University, New York, NY 10021.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoInhaled Insulin Improves Glycemic Control When Substituted for or Added to Oral Combination Therapy in Type 2 Diabetes Julio Rosenstock , Bernard Zinman , Liam J. Murphy , Stephen C. Clement , Paul Moore , C. Keith Bowering , Rosa Hendler , Shu-Ping Lan , and William T. Cefalu Efficacy and Safety of Inhaled Insulin Therapy Lorraine Tosiello and Priya Ravi Efficacy and Safety of Inhaled Insulin Therapy Harold Sox Efficacy and Safety of Inhaled Insulin Therapy Julio Rosenstock , Bernard Zinman , Liam J. Murphy , Stephen C. Clement , Paul Moore , C. Keith Bowering , Rosa Hendler , Shu-Ping Lan , and William T. Cefalu Metrics Cited ByThe research rotation: competency-based structured and novel approach to research training of internal medicine residents 4 April 2006Volume 144, Issue 7Page: 533KeywordsBody mass indexConflicts of interestExerciseHemoglobinInsulinObesityObservational studiesSafetyType 2 diabetes ePublished: 4 April 2006 Issue Published: 4 April 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...