tbuckley/cabot-search huggingface dataset:
Pulmonary manifestations of waldenstrom macroglobulinemia
Authors: P. Gregory Rausch, John C. Herion
Journal: American Journal of Hematology (1980)

Abstract Waldenstrom macroglobulinemia (WMG), a proliferation of malignant monoclonal IgM secreting plasmacytoid lymphocytes in lymph nodes, spleen, and marrow, usually pursues a chronic clinical course. A patient with WMG for five years who developed pulmonary tumors consisting of plasmacytoid lymphocytes prompted a review of the literature for pulmonary manifestations of WMG. Twenty‐six males and 18 females, ranging in age from 33 to 84 years, have been reported with histologically proven pulmonary involvement by WMG. The x‐ray findings, evident in most patients when first seen, consisted of masses (22 patients), infiltrates (31 patients), and pleural effusions (19 patients). Most patients (24) had two or more of these manifestations but only five, in addition to our patient, had isolated pulmonary nodules. Isolated pulmonary infiltrates were found in ten patients and isolated pleural effusions in only four. Symptoms at the onset of pulmonary involvement included dyspnea (54%), nonproductive cough (33%), and chest pain (7%); 15% were asymptomatic. Pulmonary manifestations, like other features of WMG, respond to alkylating agents or irradiation and do not appear to affect prognosis adversely. Pulmonary involvement should be suspected in any patient with WMG who develops an abnormal chest x‐ray.
Abstract 859: EGCG inhibits pancreatic cancer growth and stem cell characteristics in xenografts and KrasG12D transgenic mice models
Authors: Su-Ni Tang, Luke Marsh, Sharmila Shankar, Rakesh K. Srivastava
Journal: Cancer Research (2011)

Abstract FoxO (forkhead box O) transcription factors are crucial regulators of cell fate. This function of FoxO proteins relies on their ability to control diverse functions such as proliferation, differentiation, DNA repair and apoptosis. Constitutively active AKT and ERK in cancer cells have been shown to phosphorylate FoxO transcription factors (FKHR, FKHRL1 and AFX), which bind to protein 14-3-3 and sequester in the cytoplasm. In the absence of survival signals, FoxO proteins dephosphorylate, translocate to the nucleus and upregulate a series of target genes, thereby promoting cell cycle arrest and apoptosis. EGCG, a component of green tea, exerts antiproliferative and proapoptotic actions on a number of different cancer cell lines through diverse mechanisms. However, the mechanisms by which EGCG inhibits cell proliferation and induces apoptosis are poorly understood. EGCG inhibited viability and induced apoptosis in human pancreatic cancer cell lines. EGCG induces PTEN expression and inhibits Akt phosphorylation in pancreatic cancer Hs766T, AsPC-1, MIA PaCa-2 and PANC-1 cells. Treatment of PANC-1 cells with EGCG caused a decrease in ERK phosphorylation, and an increase in JNK phosphorylation. Overexpression of FOXO1, FOXO3a, and FOXO4 inhibited cell viability in PANC-1 cells. The inhibitory effects of EGCG on cell viability were further enhanced when cells were transfected with FOXO1, FOXO3a, and FOXO4. EGCG enhanced FOXO-DNA binding and transcriptional activities. Interestingly, EGCG inhibited pancreatic cancer growth and/or development in xenograft, orthotopic and KrasG12D transgenic mice models. EGCG also inhibited pancreatic cancer stem cell characteristics. In conclusion, our data demonstrate that EGCG can inhibit pancreatic cancer growth and/or development through multiple mechanisms and thus can be used for the management of pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 859. doi:10.1158/1538-7445.AM2011-859
Direct Plotting of Three‐Dimensional Hollow Fiber Scaffolds Based on Concentrated Alginate Pastes for Tissue Engineering
Authors: Yongxiang Luo, Anja Lode, Michael Gelinsky
Journal: Advanced Healthcare Materials (2012)

Porous scaffolds for tissue engineering applications consisting of hollow alginate fibers are presented. They are prepared using self-made shell/core nozzles and a 3D plotting device. Such materials open up the possibility to generate biodegradable tissue constructs with a preformed vascular system or can act as matrices for engineering of complex organs or 3D tissue models.
AN ACCOUNT OF A MALARIOUS ENDEMIC
Authors: T. P. J. Grantham
Journal: BMJ (1854)

S_AiOFIa noi the comparative frequec of ophlmic di infa twosesmitill b neearyma town and boor hood such S BbirIng , i ich machinr a unds, aA mining opertions are carried on upon an extensive male, to deduct cas of traumatic injury, burs, contusions, d extraneous bodies lodged upon the eye and its appen- das, from those diseases which have their origin m con- itutional disorder, or a peculiar atmospheric condition, Now, the instances of the former amongst the males amount (exclusive of cases of amaurosis) to 194, whilst with the females they are not more than 36; and when deducted from the gross numbers given above, will reduce them as follows:-Males... 990 Females ... ... 1116 Majority of females over males, 126.The females appear to have been more particularly obnoxious to diseases of the eye-lids, lachrymal sac, con- junctiva, and functional disorders of the retina and adjusting apparatus of the eye (asthenopia,) whilst the males have been most prone to organic disease of the iris, and of the retina.BfrmIDglam, Feb. 1854.
Periodic Updates on Prevention
Authors: CHARLES E. LEWIS
Journal: Annals of Internal Medicine (1986)

Editorials1 September 1986Periodic Updates on PreventionCHARLES E. LEWIS, M. D., SCD.CHARLES E. LEWIS, M. D., SCD.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-3-452_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMost physicians had their introductory course in preventive medicine as pre-premedical students and learned such axioms as, Don't go out at night without a sweater. . . .Always wear clean underwear, in case. . . . An apple a day. . . .For years, actions directed at the prevention of disease, with the exception of vaccination and immunization, remained largely a function of early social learning, common sense, and a matter of faith. But over the past 30 years, various researchers have labored to mine some hard scientific facts from the myths surrounding preventive health services.In the 1950s, Hochbaum...References1. ROSENSTOCK I. Why people use health services. Milbank Mem Fund Q. 1966;44(suppl):94-122. CrossrefGoogle Scholar2. BECKER M, HAEFNER D, KASL S, KIRSCHT J, MAIMAN L, and ROSENSTOCK I. Selected psychosocial models and correlates of individual health-related behaviors. Med Care. 1977;15(5 suppl):27-46. CrossrefMedlineGoogle Scholar3. LUFT H. Why do HMOs seem to provide more health maintenance services? Milbank Mem Fund Q. 1978;56:140-68. CrossrefGoogle Scholar4. . The periodic health examination. Can Med Assoc J. 1979;121:1193-254. MedlineGoogle Scholar5. . The periodic health examination: 2. 1984 update. Can Med Assoc J. 1984;130:1278-85. MedlineGoogle Scholar6. . The periodic health examination: 2. 1985 update. Can Med Assoc J. 1985;134:724-7. Google Scholar7. LEWIS C, WELLS K, and WARE J. A model for predicting the counseling practices of physicians. J Gen Intern Med. 1986;1:14-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES E. LEWIS, M. D., SCD. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErnährungs- und Stoffwechselstörungen 1 September 1986Volume 105, Issue 3Page: 452-453KeywordsMedical servicesPreventive medicineVaccination and immunization ePublished: 1 December 2008 Issue Published: 1 September 1986 PDF downloadLoading ...
Prognosis of isolated seizures in adult life.
Authors: P G Cleland, I Mosquera, W P Steward, J B Foster
Journal: BMJ (1981)

After 28 days urine cultures showed cytopathic changes characterised by cytoplasmic vacuolisation.Electron microscopy of the supernatant showed icosahedral virus particles with a diameter of about 45 nm.Supernatants from the urine cultures agglutinated human type 0 erythrocytes and the agglutination could be inhibited by a specific anti-BK virus serum.No cytopathic effect was observed in control cells and throat swab cultures.Seroconversion against BK virus between the third and 14th day of the disease (haemagglutination inhibiting antibody titres 1:8-1:256) was shown.Similar titres were obtained when the patient's virus was used as the antigen.No appreciable rises in antibodies to adenovirus, respiratory syncytial virus, influenza virus types A and B, Mycoplasma pneumoniae, and Chlamydia psittaci were observed as measured by the complement fixation test.Analysis of the viral DNA by cleavage with several restriction endonucleases showed a pattern compatible with BK virus-like human papovaviruses. CommentThis report describes seroconversion against BK virus and subse- quent isolation of virus from the urine of a child with acute tonsillitis.The child's humoral and cellular immunity was not impaired and no immunosuppressive treatment was given.Our findings should encourage further attempts to isolate BK virus from patients with acute respiratory disease.
Extensive Cerebral Venous Thrombosis
Authors: Sarah Nelson, Bryan Ho
Journal: JAMA Neurology (2013)

A50-year-oldmanwithahistoryofhyperlipidemiapresentedwith worseningheadachefollowingamotorvehiclecrashthathadcaused a closed head injury. He had no neurologic deficits and optic discs weredifficult to appreciate.Hypercoagulable panel results (including antithrombin III, factor V Leiden, prothrombin G20210Amutation, protein C, protein S, lupus anticoagulant, anticardiolipin antibodies, and β-2 microglobulin) were unremarkable. Computed tomographicheadnoncontrastonadmissionhaddemonstratedpossible cerebral venous thrombosis, and computed tomographic venography was performed to confirm this diagnosis (Figure 1). Thepatientwas treatedwithanticoagulationconsistingofheparin drip with bridge to warfarin. Pain medications were administered on an as-needed basis. He subsequently underwent follow-up imaging 1.5months later (Figure2).Thepatientalso reported at that time that his headache had improved. He continues taking maintenance warfarin therapy.
Abstract 2911: SAR125844: a potent and selective ATP-competitive inhibitor of MET kinase
Authors: Laurent Schio, Conception Nemecek, Antonio Ugolini, Sylvie Wentzler, Sandrine Grapinet, Jean Khider, Eva Albert, Nathalie Dischamps, Frédéric Gay, Véronique Sonnefraud, Eric Bacqué, Mireille Kenigsberg, Hélène Goulaouic, Anne Dagallier, François Vallée, Fabrice Bonche, Christoph Lengauer
Journal: Cancer Research (2012)

Abstract The tyrosine kinase MET is a membrane receptor that is essential for embryonic development and wound healing in normal cells. Stimulation of MET by its natural ligand, the hepatocyte growth factor (HGF), induces cell proliferation, migration, and invasion. Abnormal MET activation (over-expression of MET protein, amplification or mutations of the MET gene) has been observed in multiple human cancer types. We report herein the discovery of a potent and selective small molecule inhibitor (SAR125844) with potential therapeutic application in cancer patients with deregulated MET-dependent malignancies. Our initial hit identification approach was based on the biochemical screen of an in-house kinase inhibitor biased library where a series of benzimidazole sulfonate derivatives were identified with sub-micromolar MET inhibition. In particular, the initial hit exhibited an IC50 of 140 nM vs MET but it also had strong affinity for CDK9 (IC50= 6 nM), a CDK isoform involved in gene transcription. Chemical modifications of the series to dial out CDK9 affinity and remove potential normal cell cytotoxicity led to a more selective derivative with IC50's of 80nM and 1355nM vs MET and CDK9 respectively. Further sub-structural exploration allowed us to identify a heteorocyclic moiety which was shown by X-ray data to specifically interact with Tyr1230 in a non active conformation of the protein. The resulting highly favourable U-shape mode of binding in MET of representative examples from these series (e.g. IC50= 1nM) was not tolerated in CDK9 (IC50 &amp;gt; 10µM). Final multi-parametric medicinal chemistry optimisation led to SAR125844 with single digit nanomolar antiproliferative activity on MET-amplified cell lines. SAR125844 is highly selective for MET kinase in a panel of 275 kinases tested, with only 5 other protein kinases inhibited at IC50 values below 300 nM. This compound exhibits also satisfactory eADMET in vitro properties and has shown moderate total plasma clearance, large volume of distribution and moderate to long terminal elimination half-life in rats. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2911. doi:1538-7445.AM2012-2911
Evidence Excluding the Root of the Tree of Life from the Actinobacteria
Authors: J. A. Servin, C. W. Herbold, R. G. Skophammer, J. A. Lake
Journal: Molecular Biology and Evolution (2007)

The Actinobacteria are found in aquatic and terrestrial habitats throughout the world and are among the most morphologically varied prokaryotes. They manufacture unusual compounds, utilize novel metabolic pathways, and contain unique genes. This diversity may suggest that the root of the tree of life could be within the Actinobacteria, although there is little or no convincing evidence for such a root. Here, using gene insertions and deletions found in the DNA gyrase, GyrA, and in the paralogous DNA topoisomerase, ParC, we present evidence that the root of life is outside the Actinobacteria.
VENTRAL HERNIA: A DEVICE TO STRENGTHEN THE ABDOMINAL WALL
Authors: H. H. Greenwood
Journal: BMJ (1918)

VENTRAL HERNIA.[SPT.2I, Igr8 H.'s culture from faeces was then employed and a fairly thick enmulsion from an agar slope yielded with-the serums the following results: H.'s Bacilluts wlith1 Serums. 1 in 25. 1 in 50.l in 125.D. H.'s serum ... .
In situ quantification of T-lymphocyte subsets and Langerhans cells in the inflammatory infiltrate of atopic eczema
Authors: C. B. ZACHARY, M. H. ALLEN, D. M. MACDONALD
Journal: British Journal of Dermatology (1985)

Tissue from the acute, non-infected eruption of sixteen atopic eczema subjects was subjected to an indirect immunoperoxidase technique using monoclonal antibodies recognizing T-lymphocyte subsets, Langerhans cells and natural killer cells. Over half the cells infiltrating the dermis were T lymphocytes, including a large majority of helper T cells and relatively few suppressor T cells. Langerhans cells were present in significant proportions in the dermis and probably reflected increased antigen presentation within the affected skin. There was no evidence of increased natural killer cell presence. This study suggests that type IV hypersensitivity may be implicated in the aetiology of atopic eczema.
We need scientific consensus founded on all the evidence
Authors: K. McPherson
Journal: BMJ (2011)

Although Richards’s independent review of the evidence on this important policy for women—including the screening publicity—is welcome, it is long overdue.1 2 For many years maturing trials, proper scrutiny, and new independent studies have increasingly questioned the bases on which the decision to implement screening was made in the 1980s. It is obviously incumbent on those responsible for screening policy to ensure that it—and the information—take account …
THE LIFE-HISTORY OF THE FIRST CASE OF MYXOEDEMA TREATED BY THYROID EXTRACT
Authors: G. R. Murray
Journal: BMJ (1920)

Only three tappings of the abdomen were necessary after commencing the diet, and the oedema of the legs, thighs, Scrotum, anid penis gradually subsided; the lumbar cushion afiGo disappeared.A marked loss of weight, due no doubt to the elimination of fluid, was later succeeded by a steady gain as nutrition improved.Nothing could be more satisfactory than the way in which the fluid which waterlogged this patient was induced to disperse.His subsequent historv is, however, well worth noting.It is over a twelvemonth since his last tapping.He continues his diet on much the same lines, remains free from ascites and oedema, has put on flesh and looks and feels much better, but his urine is still highly albuminous, and his blood pressure has gradually risen until the systolic pressure is 220 mm. of mercury.
Hepatic artery embolisation with a novel radiopaque polymer causes extended liver necrosis in pigs due to occlusion of the concomitant portal vein
Authors: Christoph A Maurer, Pietro Renzulli, Hans U Baer, Daniel Mettler, Georg Uhlschmid, Peter Neuenschwander, Ulrich W Suter, Jürgen Triller, Arthur Zimmermann
Journal: Journal of Hepatology (2000)
The first decade of aortocoronary bypass grafting, 1967-1977. A review.
Authors: H D McIntosh, J A Garcia
Journal: Circulation (1978)

Despite a decade of experience with aortocoronary bypass grafting embracing 300,000 or more operations, indications for its use remain controversial. The controversy persists because of a lack of adequate controls with which to compare the clinical course of operated patients; only 1248 have been reported who have been studied in a carefully controlled and random manner. Benefit has been claimed frequently by comparing the course of patients treated surgically with medically treated patients followed the decade before. Such comparisons are not valid in view of the well documented changes in the natural history of coronary artery disease that have been occurring during the last decade. Despite a low operative mortality and rate of graft closure, available data in the literature do not indicate that initial symptomatic improvement necessarily persists, or that myocardial infarctions, arrhythmias, or congestive heart failure will be prevented, or that life will be prolonged in the vast majority of operated patients.
The Roles of Estrogen and Progesterone in Breast and Genital Cancer
Authors: Robert A. Wilson
Journal: JAMA (1962)

The incidence of mammary and genital cancer was investigated in a group of 304 women whose ages ranged from 40 to 70 years (average 50.8) and who were treated with exogenous estrogens for periods up to 27 years (average 7.8). The breasts were thus exposed to estrogen for 2,387 patient-years. The genital exposure was only 1,852 patient-years because 86 patients underwent total hysterectomy and oophorectomy. The author estimates that 18 cases of cancer, either mammary or genital, were to be expected in the group; instead, no cases occurred. On this basis, it is urged that estrogens and progestins be studied more intensively for possible prophylactic effects against mammary and genital cancer.
Id2 Is Dispensable for Myc-Induced Lymphomagenesis
Authors: Jonas A. Nilsson, Lisa M. Nilsson, Ulrich Keller, Yoshifumi Yokota, Kelli Boyd, John L. Cleveland
Journal: Cancer Research (2004)

Abstract The Eμ-Myc transgenic mouse appears to be an accurate model of human Burkitt’s lymphoma that bears MYC/Immunoglobulin gene translocations. Id2, a negative regulator of basic helix-loop-helix transcription factors, has also been proposed as a Myc target gene that drives the proliferative response of Myc by binding to and overriding the checkpoint functions of the retinoblastoma tumor suppressor protein. Targeted deletion of Id2 in mice results in defects in B-cell development and prevents the development of peripheral lymphoid nodes. In precancerous B cells and lymphomas that arise in Eμ-Myc transgenic mice and in Burkitt’s lymphomas, Id2 is overexpressed, suggesting that it plays a regulatory role in lymphoma development. Surprisingly, despite these connections, Eμ-Myc mice lacking Id2 succumb to lethal B-cell lymphoma at rates comparable with wild-type Eμ-Myc transgenics. Furthermore, precancerous splenic B cells lacking Id2 do not exhibit any significant defects in Myc-induced target gene transactivation and proliferation. However, due to their lack of secondary lymph nodes, Eμ-Myc mice lacking Id2 rather succumb to disseminated lymphoma with an associated leukemia, with pronounced infiltrates of the bone marrow and other major organs. Collectively these findings argue that targeting Id2 functions may be ineffective in preventing Myc-associated malignancies.
On a New Apparatus for Fracture of the Thigh
Authors: F. A. Bulley
Journal: BMJ (1841)

diately retracted about a.qumter ofian inch.Ninety days after the injury, the fracture was founid to be united by a, dense fibrons tissue; and a quantity 6f new osseous matter extended from the broken extremnities into the fibrous aub- stance, of the form, and.about equal to the original size of the fragments, whichl has thus assutmed the appearance of two symmetrical patelme.
Increased levels of circulating intercellular adhesion molecule-1 in patients with localized scleroderma
Authors: Hironobu Ihn, Manabu Fujimoto, Shinichi Sato, Kanako Kikuchi, Atsuyuki Igarashi, Yoshinao Soma, Kazuhiko Takehara
Journal: Journal of the American Academy of Dermatology (1994)
Early related or unrelated haematopoietic cell transplantation results in higher overall survival and leukaemia-free survival compared with conventional chemotherapy in high-risk acute myeloid leukaemia patients in first complete remission
Authors: N Basara, A Schulze, U Wedding, M Mohren, A Gerhardt, C Junghanss, N Peter, G Dölken, C Becker, S Heyn, C Kliem, T Lange, R Krahl, W Pönisch, H-J Fricke, H G Sayer, H Al-Ali, F Kamprad, D Niederwieser
Journal: Leukemia (2009)
Glutamatergic Plasticity by Synaptic Delivery of GluR-Blong-Containing AMPA Receptors
Authors: Alexander Kolleker, J.Julius Zhu, Bettina J Schupp, Yi Qin, Volker Mack, Thilo Borchardt, Georg Köhr, Roberto Malinow, Peter H Seeburg, Pavel Osten
Journal: Neuron (2003)
Intravenous iron increases labile serum iron but does not impair forearm blood flow reactivity in dialysis patients
Authors: Georg Schaller, Barbara Scheiber-Mojdehkar, Michael Wolzt, Heidi Puttinger, Friedrich Mittermayer, Walter H. HuRl, Manuela Fadinger, Gere Sunder-Plassmann, Andreas Vychytil
Journal: Kidney International (2005)
Intestinal Ischemia and Digitalis
Authors: R. Adar
Journal: JAMA (1974)

To the Editor. —  In his letter (227:1263, 1974), Dr. Ko succinctly analyzed the dilemma of the elderly patient in whom mesenteric ischemia developed secondary to congestive heart failure. While it is probably true that digitalis preparations can intensify mesenteric vasoconstriction in these patients, it is equally clear that the continued decrease in cardiac output is also detrimental. In addition to the adrenergic mechanism suggested by Ko, it has been appreciated recently that in low cardiac output states the renin-angiotensin system is stimulated, 1 and the elevated level of circulating angiotensin II may well contribute to the mesenteric vaso constriction seen with low cardiac output.  The specific agents that block the action of the renin-angiotensin system (eg, the Bothrops nonapeptide that inhibits the enzymatic conversion of angiotensin I to II and 1-sar, 8-ala, angiotensin that competitively inhibits angiotensin II) are available at present for experimental use. 1 In our laboratory,