Impaired Hepatic Catabolism of Melatonin in Cirrhosis
Authors: Petra E. Steindl
Journal: Annals of Internal Medicine (1997)

Letters15 September 1997Impaired Hepatic Catabolism of Melatonin in CirrhosisPetra E. Steindl, MD, Peter Ferenci, MD, and Wolfgang Marktl, MDPetra E. Steindl, MDUniversity of Vienna; Vienna, AustriaSearch for more papers by this author, Peter Ferenci, MDUniversity of Vienna; Vienna, AustriaSearch for more papers by this author, and Wolfgang Marktl, MDUniversity of Vienna; Vienna, AustriaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-6-199709150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Prompted by Garfinkel and Zisapel's comment [1] on our paper, published in August 1995 [2], we present some consecutive data. We postulated that elevated plasma melatonin levels and an altered 24-hour profile of the hormone we found in patients with liver cirrhosis [2] could represent an altered output of the circadian clock [3], causing a central disturbance of circadian rhythmicity.Garfinkel and Zisapel suggested that we measure the urinary metabolite of melatonin, 6-sulfatoxymelatonin, to determine whether increased production in the pineal gland or decreased catabolism by the liver is the main reason for elevated serum melatonin levels ...References1. Garfinkel D, Zisapel N. Liver cirrhosis and circadian rhythm [Letter]. Ann Intern Med. 1996; 125:154. Google Scholar2. Steindl PE, Finn B, Bendok B, Rothke S, Zee PC, Blei AT. Disruption of the diurnal rhythm of plasma melatonin in cirrhosis. Ann Intern Med. 1995; 123:274-7. Google Scholar3. Rosenthal NE. Plasma melatonin as a measure of the human clock. J Clin Endocrinol Metab. 1991; 73:225-6. Google Scholar Author, Article, and Disclosure InformationAuthors: Petra E. Steindl, MD; Peter Ferenci, MD; Wolfgang Marktl, MDAffiliations: University of Vienna; Vienna, Austria PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCircadian rhythms and the liverPrevalence of and Factors Associated with Sleep-Wake Abnormalities in Patients with CirrhosisThe role of astrocytes in generating circadian rhythmicity in health and diseaseSerum melatonin in dogs with congenital portosystemic shunting, with and without hepatic encephalopathyAlterations in circadian rhythms following alcohol use: A systematic reviewChallenging Circadian Rhythm Disorder CasesIs melatonin effective for pruritus caused by liver disease?Morning Bright Light Treatment for Sleep-Wake Disturbances in Primary Biliary Cholangitis: A Pilot StudyFatigued patients with chronic liver disease have subtle aberrations of sleep, melatonin and cortisol circadian rhythmsClinical and Neurologic Manifestation of Minimal Hepatic Encephalopathy and Overt Hepatic EncephalopathyAssessment of 6-sulfatoxymelatonin rhythms and melatonin response to light in disease states: Lessons from cirrhosisPrevalence of Insomnia and Sleep Patterns among Liver Cirrhosis PatientsSleep-wake abnormalities in patients with cirrhosisSleep-Wake profiles in patients with primary biliary cirrhosisThe circadian clock: a framework linking metabolism, epigenetics and neuronal functionSleep Disorders and Hepatic EncephalopathyCircadian rhythms and sleep—the metabolic connectionOn the Origin and the Consequences of Circadian Abnormalities in Patients With CirrhosisAltered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachlorideSleep and circadian abnormalities in patients with cirrhosis: features of delayed sleep phase syndrome?Concomitant changes in melatonin metabolism and in hypothalamic histamine in rats with a portacaval anastomosisCirrhosis does not shift the circadian phase of plasma fibrinolysis 15 September 1997Volume 127, Issue 6Page: 494KeywordsBlood plasmaCatabolismCirrhosisExcretionLiverMelatoninPrimary biliary cirrhosisResearch laboratoriesStatistical methodsUrine ePublished: 15 August 2000 Issue Published: 15 September 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...