tbuckley/cabot-search huggingface dataset:
Arterial and portal circulation and parenchymal changes in Budd-Chiari syndrome: A study in 17 explanted livers
Authors: Dominique Cazals-Hatem, Valérie Vilgrain, Pascal Genin, Marie-Hélène Denninger, François Durand, Jacques Belghiti, Dominique Valla, Claude Degott
Journal: Hepatology (2003)

Hepatic parenchymal changes associated with Budd–Chiari syndrome (BCS) have been tentatively explained by combined arterial and portal perfusion disturbances in addition to the complete occlusion of hepatic veins. The aim of this study was to correlate pretransplant course and vascular imaging with pathologic findings in livers explanted for BCS. Seventeen consecutive white patients who underwent transplantation for severe classic BCS were retrospectively analyzed. Pretransplant course was 1 year or less in 8 patients and more than 1 year in 9 patients. Thrombophilia was found in 16 patients (94%). Imaging showed decreased portal perfusion in 16 patients (94%) and increased arterial perfusion in 9 patients. Histology showed obstructive portal venopathy and nodular regenerative hyperplasia (NRH) aspects in all cases, large regenerative nodules resembling focal nodular hyperplasia (FNH) in 9 cases, and cirrhosis in 2 cases. Patients with increased arterial inflow had large regenerative nodules and a protracted pretransplant course. Patients with acute thrombi in portal veins had parenchymal infarcts (2 cases) and a short pretransplant course. In conclusion, patients with severe BCS have a constant impaired perfusion inflow unrelated to progression of cirrhosis but related to the outcome. An early decrease in portal perfusion is observed in the short term and is responsible for NRH or infarcts if complicated with large thrombi. An increase in arterial perfusion compensates impaired portal flow in chronic BCS. Arterial hyperemia contributes to the development of large regenerative nodules that are FNH–like. This pathologic situation offers an interesting vascular model to further understand the parenchymal response to changes in hepatic blood flow.
Desmoglein-1–specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem)
Authors: Mong-Shang Lin, Chang-Ling Fu, Valeria Aoki, Gunter Hans-Filho, Evandro A. Rivitti, Jose R. Moraes, Maria E. Moraes, Ana Maria Lazaro, George J. Giudice, Peter Stastny, Luis A. Diaz
Journal: Journal of Clinical Investigation (2000)

Fogo selvagem (FS), the endemic form of pemphigus foliaceus, is a cutaneous autoimmune disease characterized by subcorneal blistering of the epidermis and the production of autoantibodies against the desmosomal antigen desmoglein-1 (Dsg1). Previously, we showed that mice injected with autoantibodies from FS patients develop a skin disease that reproduces the clinical, histological, and immunological features of FS, indicating that autoantibodies play an essential role in the development of this disease. The purpose of this study was to characterize the autoimmune T-cell response associated with FS. We provide here the first evidence, to our knowledge, that the great majority of FS patients have circulating T lymphocytes that specifically proliferate in response to the extracellular domain of Dsg1. Long-term T cells developed from these patients also responded to Dsg1, and this antigen-specific response was shown to be restricted to HLA-DR molecules. These Dsg1-reactive FS T cells exhibited a CD4-positive memory T-cell phenotype and produced a T helper 2–like cytokine profile. These findings represent the initial steps in defining the role of T cells in FS autoimmunity.
Clinical Psychiatry and the Law
Authors: Bruce L. Danto
Journal: JAMA (1993)

This book, a formidable work of 652 pages, is a practical and scholarly guide through the legal issues that involve psychiatrists and the whole mental health field of professionals. Clinical vignettes are used to introduce each chapter. The author states his purpose in writing the book as "to facilitate the clinical management of legal issues so that good patient care will be enhanced." The book's perspective is medical, not necessarily legal. Valuable insights are offered about psychiatrist-patient relationships, malpractice, the ethics of practice, confidentiality, testimonial privilege, the patient's right to refuse treatment, and informed consent. "Therapists need to feel comfortable with the idea that they do not have to feel helpless if a patient threatens with either suicide or homicide..." I wish that I had more time and space to devote to this review, because I am so excited about the book's usefulness, artful writing, and clarity. What I can
Conjoined Twins — The Limits of Law at the Limits of Life
Authors: George J. Annas
Journal: New England Journal of Medicine (2001)

Conjoined twins have been the subject of scientific exhibits, medical study, human curiosity, and even entertainment, but until the year 2000, conjoined twins had never been the subject of a courtroom battle. A unique case that was the subject of two British court decisions deserves study.1 The case illustrates the difficulty of applying legal principles to unprecedented life-and-death decisions involving proposed medical interventions for children — particularly when parents and physicians disagree about what should be done.The conjoined twins who were the subject of the court decisions are identified by the judges only as Jodie and Mary. They are . . .
Abstract 1459: Mining for metastasis genes in osteosarcomas from <i>p53 +/R172H</i> mice
Authors: Shunbin Xiong, Young-Ah Suh, Alfonso Quintás-Cardama, Guillermina Lozano
Journal: Cancer Research (2011)

Abstract Osteosarcoma (OS) is the most frequent bone cancer in young adults. The 5-year relapse free survival rates in nonmetastatic osteosarcomas are up to 65%, while metastatic osteosarcomas are only 10-20%. Therefore, identifying genes involved in OS metastasis is important to risk-stratify patients and enable development of novel therapeutic targets. In mouse models, loss of one p53 allele causes 34% of mice to develop OS without obvious metastasis; however, mice carrying a p53 missense mutation (R172H) develop metastatic OS. To screen for gene expression differences in metastatic potential between p53+/− and p53R172H/+ osteosarcomas, we used Affymetrix Mouse Genome 430 2.0 chips and compared three p53+/− and eight p53R172H/+ primary OS tumors. Two hundred thirteen genes were identified that had a p value &amp;lt; 0.05 and an average fold difference of 2. Only 20 of these genes had reported gene functions that affected cell migration, invasion, cell-cell junctions, or tumor phenotypes, or were selected based not only on statistical significance but also because they were consistently up (or down) regulated in all 8 R172H/+ tumors analyzed. Of these 20 genes, eight were validated by q-PCR in a larger group of tumors; S100A8, S100A9, PLA2G16, Plac8, and MAP kinase-interacting serine/threonine kinase 2 (Mnk2) were elevated while FAT4, FAT3, and Brdw1 showed decreased expression in mutant p53 tumors. To further characterize the functions of these genes in OS metastasis, we chose a metastatic OS cell line (H318) derived from p53R172H/+ tumor that had lost the wild type p53 allele for short hairpin RNAs (shRNAs) knock-down experiments followed by screening for migration and invasion. Three of these genes, PLA2G16, Plac8, and Mnk2, showed effects on migration and invasion in vitro. Further studies led us to focus on PLAG2G16. Knock-down of PLA2G16 showed decreased migration, invasion and proliferation. Additionally, we also subcutaneously injected PLAG2G16 knock-down cells into congenic wild type mice. Remarkably these cells showed dramatic decrease in tumor progression and metastasis. These effects were reproducible in another cell line with a different p53 mutant, 4T1. To determine whether we could make a non-metastatic cell adopt metastatic properties by simply expressing PLA2G16, we expressed FLAG-tagged PLA2G16 in two p53-null cell lines that lacked metastatic potential. These cells showed a 2-fold and 7-fold increase in invasion in culture, respectively. These preliminary data suggest that the expression of PLA2G16 in mutant p53 cell lines contributes to migration, invasion, and metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1459. doi:10.1158/1538-7445.AM2011-1459
Salbutamol inhibits pulmonary effects of platelet activating factor in man.
Authors: J Roca, M A Félez, K F Chung, J A Barberà, M Rotger, C Santos, R Rodriguez-Roisin
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Inhaled platelet-activating factor (PAF) provokes considerable pulmonary gas exchange disturbances in normal man and in patients with mild asthma, similar to those observed in acute severe asthma. To further examine the mechanisms involved in PAF-induced ventilation-perfusion (VA/Q) mismatch, eight healthy, non-atopic, nonsmoking subjects were studied after administration of PAF aerosol (24 micrograms). They had been previously treated with inhaled salbutamol (300 micrograms) in a randomized, double-blind, cross-over, placebo-controlled design. After placebo, PAF provoked a fall in total arterial white cell count with a rebound leukocytosis. As shown in a previous study, an overall index of VA/Q inequality (DISP R-E*, 1.64 +/- 0.10) showed a threefold increase (P < 0.006) that accounted for the increase (79%) in AaPO2 (p < 0.04) after PAF, while the respiratory system resistance (Rrs) rose by 16% (p < 0.02). In contrast, after pretreatment with salbutamol inhaled PAF had no effects on pulmonary gas exchange, Rrs, or white cell count; facial flushing and cough were also hindered. The results are consistent with the hypothesis that salbutamol inhibits PAF-induced venoconstriction in both the airway and pulmonary microcirculation.
Information for the Physician
Authors: Pasquale F. Finelli
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 April 1989Information for the PhysicianPasquale F. Finelli, MDPasquale F. Finelli, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-8-670 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The problem of information overload was addressed previously (1) and in a recentAnnalseditorial (2). Dr. Huth refers to the "brain's limited capacity for storage and processing of information," and the "unmanageable size" of journal literature. The dilemma remains and a solution is still awaited. Guidelines for the ideal information system stated it should be rapidly accessible, precisely and accurately responsive to specific questions, and cheap in time and other costs. The information should be expertly selected, carefully assessed, highly relevant, and current. The question was also raised as to who should develop such a system....References1. Huth E. Needed: an economics approach to systems for medical information. Ann Intern Med. 1985;103:617-9. LinkGoogle Scholar2. Huth E. The underused medical literature [Editorial]. Ann Intern Med. 1989;110:99-100. LinkGoogle Scholar3. Finelli P. NERVLINE, a microcomputer information retrieval system in the clinical neurosciences. NERVLINE Inc. Butterworth Publications; 1989. Google Scholar1. Huth E. The underused medical literature [Editorial]. Ann Intern Med. 1989;110:99-100. LinkGoogle Scholar1. Huth E. The underused medical literature [Editorial]. Ann Intern Med. 1989;110:99-100. LinkGoogle Scholar2. WilliamsonGermanWeissSkinnerBowes JPREF. Health science information management and continuing education of physicians. Ann Intern Med. 1989;110:151-60. LinkGoogle Scholar3. Louis Harris and Associates. The Future of Information Systems for the Medical Sciences: A Study Conducted for the New York Academy of Medicine. New York: Louis Harris and Associates; 1987. Google Scholar4. Lewis C. A library for internists V. Ann Intern Med. 1985;102:423-37. LinkGoogle Scholar5. HaynesMcKibbonFitzgeraldGuyattWalkerSackett RADGCD. How to keep up with the medical literature: VI. How to store and retrieve articles worth keeping. Ann Intern Med. 1986;105:978-84. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Pasquale F. Finelli, MDAffiliations: Brown University Memorial Hospital of Rhode Island Pawtucket, RI 02860 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Reversible Dementias: Do They Reverse? 15 April 1989Volume 110, Issue 8Page: 670-672KeywordsBrainInformation technology ePublished: 1 December 2008 Issue Published: 15 April 1989 PDF downloadLoading ...
Symptoms, Quality of Life, and Health Service Contact among Young Adults with Mild Asthma
Authors: LIESL M. OSMAN, CHRISTINE CALDER, ROMA ROBERTSON, JAMES A. R. FRIEND, JOSEPH S. LEGGE, J. GRAHAM DOUGLAS
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

This report assesses Quality of Life (QoL) and its relationship to current symptoms and prospective medical contact among 396 adult patients with asthma. Patients were 16 to 52 yr of age and in the care of family physicians in the northeast of Scotland. All patients had been prescribed asthma medication within the previous 3 mo. Mean %pred FEV1 was 87.4, mean %pred PEF was 85.1; 41% reported respiratory symptoms every week in the month before interview. Patients completed the SF-36, SF-12, and St. George's Respiratory Questionnaire (SGRQ) scales. Although mean scores on the SF-36 and SF-12 were close to population norms for patients without chronic illness, the presence of any respiratory symptoms in the month before interview was related to significantly lower QoL scores on the SF-36 scales of Physical Functioning, Energy, Mental Health, Pain, and Health Perception: the SF-12 Physical Functioning scale, and the SGRQ Symptoms, Impact and Activities scales. Physician contact for asthma in the 12 mo after interview was significantly related to SF-36, SF-12, and SGRQ scores at time of interview; however, when adjusted for symptoms at time of interview, only the SGRQ scales remained significant predictors of prospective physician contact. We conclude that respiratory symptoms have significant impact on QoL among patients with mild asthma, measured by generic and respiratory QoL scales, but that a specific respiratory scale is better able to discriminate patients who will seek physician care for asthma. Osman LM, Calder C, Robertson R, Friend JAR, Legge JS, Douglas JG. Symptoms, quality of life, and health service contact among young adults with mild asthma.
Nosocomial Fungemia in a Normal Host
Authors: Donald R. Graham
Journal: JAMA (1983)

To the Editor.—  Fungemias are occasional complications of diseases of immunosuppression. Disseminated histoplasmosis, blastomycosis, and coccidioidomycosis are known to occur in otherwise normal hosts, and recently D'Silva et al reported a case of disseminated aspergillosis in a presumably immunocompetent host (1982;248:1495). However, nosocomial fungemia is thought to relate to immune disorders. 1 This report describes an apparently healthy patient in whom Candida tropicalis fungemia developed.  Report of a Case.—  A 56-year-old man with mild cerebral palsy fell on Feb 3, 1982, and sustained a comminuted fracture of the right hip. The hip was fixed internally with a Zimmer key-free screw and plate. The wound drained for two weeks and closed secondarily. Pain continued in the hip for the next five months, but the patient remained afebrile. A roentgenogram on July 20 indicated migration of the prosthesis, so it was removed; culture of the purulent bone yielded Staphylococcus aureus . He was
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
Authors: Gerald P. Linette, Edward A. Stadtmauer, Marcela V. Maus, Aaron P. Rapoport, Bruce L. Levine, Lyndsey Emery, Leslie Litzky, Adam Bagg, Beatriz M. Carreno, Patrick J. Cimino, Gwendolyn K. Binder-Scholl, Dominic P. Smethurst, Andrew B. Gerry, Nick J. Pumphrey, Alan D. Bennett, Joanna E. Brewer, Joseph Dukes, Jane Harper, Helen K. Tayton-Martin, Bent K. Jakobsen, Namir J. Hassan, Michael Kalos, Carl H. June
Journal: Blood (2013)
Prophylaxis Against Deep-Vein Thrombosis
Authors: Lorraine Day
Journal: JAMA (1988)

<h3>To the Editor.</h3> —We were distressed by a recent article about deep-vein thrombosis (DVT) by Oster et al.<sup>1</sup>In this drug company-sponsored analysis of the risks and cost-effectiveness of prophylaxis against DVT, the authors conclude that all patients undergoing major orthopedic surgery require one of their recommended prophylactic regimens. This conclusion is unsupportable with the data that the authors have chosen to include or exclude in their analysis. To begin with, the authors assume that all DVTs are associated with pulmonary embolism (PE). They mention that calf-vein thromboses are relatively insignificant and that they do not represent a major risk to patients. However, despite this comment, they base their data on articles that measure the effectiveness of prophylaxis against calf DVT. Second, they quote statistics on the clinical incidence of PE that are out-of-date. It now is appreciated that approximately 1% of patients undergoing total hip or total knee
Limits of Medical Responsibility in Prolonging Life
Authors: Vincent J. Collins
Journal: JAMA (1968)

Today in medicine we have the capacity (1) to sustain vital life functions by artificial means, and (2) to make a composite man by the transplantation of organs. Phenomenal technological and scientific advances in medical science make it possible to prolong threatened life to an incredible degree. An essential question arises, however, as to whether at times we are dealing with true human life.  When the vital functions are maintained, the integrity of the brain and of other organs can be sustained at their particular capacity at the moment of decision, and functional recovery will likely occur and a rational human being restored. Sometimes, the vital organs are irreparably damaged by injury or disease, and recovery or reanimation to a spontaneous level is impossible. Although, we may be able to use extraordinary means to sustain the biological activities of organs and provide the semblance of existence, an integrated spontaneous existing
Traumatic Retroperitoneal Hematoma Illustrated on Tc-99m Methylene Diphosphonate Bone Scintigraphy in a Patient Presenting With a Fall
Authors: Huong Van Nguyen, Quee Li Chiam, Hugh Dixson, Kim A. Goddard
Journal: Clinical Nuclear Medicine (2007)

Retroperitoneal haematoma is rarely described in the context of bone scintigraphy, as it is usually an incidental discovery on bone scan carried out for another purpose. We report a case of a right retroperitoneal haematoma detected on Tc-99m-methylene diphosphonate bone scintigraphy taken in an elderly patient presenting with a mechanical fall and a right acetabular fracture.
REFERENCE VALUES FOR RIGHT VENTRICULAR GEOMETRY AND FUNCTION BY 3D ECHOCARDIOGRAPHY: A MULTICENTER STUDY OF 533 HEALTHY SUBJECTS
Authors: Luigi P. Badano, Francesco Maffessanti, Denisa Muraru, Paola Gripari, Roberta Esposito, Maurizio Galderisi, Gloria Tamborini, Ciro Santoro, Davide Ermacora, Mauro Pepi
Journal: Journal of the American College of Cardiology (2013)
Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levels
Authors: J Ashley Jefferson, Elizabeth Escudero, Maria-Elena Hurtado, Jacqueline Pando, Rosario Tapia, Erik R Swenson, Josef Prchal, George F Schreiner, Robert B Schoene, Abdias Hurtoado, Richard J Johnson
Journal: The Lancet (2002)
The Etiology of Mitral Regurgitation: The Marfan Syndrome.
Authors: Charles F. Wooley
Journal: Annals of Internal Medicine (1965)

s1 May 1965The Etiology of Mitral Regurgitation: The Marfan Syndrome.Charles F. Wooley, M.D., Don M. Hosier, M.D., William Molnar, M.D., Joseph M. Ryan, M.D., F.A.C.P.Charles F. Wooley, M.D.Search for more papers by this author, Don M. Hosier, M.D.Search for more papers by this author, William Molnar, M.D.Search for more papers by this author, Joseph M. Ryan, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1070_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of varying cardiovascular abnormalities in patients with the Marfan syndrome, particularly aortic dilatation, regurgitation, and dissection, is well-recognized. However, mitral valve deformities as part of the Marfan syndrome have been recognized and reported infrequently.The association of the Marfan syndrome, mitral regurgitation due to intrinsic abnormalities of the mitral valve complex, and dilated sinuses of Valsalva with large aortic cusps (without aortic regurgitation) is the subject of this report.Four female patients with evidence of the Marfan syndrome (one infant, one child, and two adults) were studied. All had auscultatory and either catheterization or cineradiographic evidence or both... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPathogenesis of primary abnormalities of the mitral valve in Marfan's syndrome. 1 May 1965Volume 62, Issue 5Page: 1070-1070KeywordsCatheterizationEtiologyInfantsMarfan syndromeMitral insufficiency Issue Published: 1 May 1965 PDF DownloadLoading ...
Endoscopic Submucosal Dissection Using a Novel Irrigation Hood-Knife
Authors: K. Kume, M. Yamasaki, K. Kanda, I. Yoshikawa, M. Otsuki
Journal: Endoscopy (2005)

Endoscopic submucosal dissection techniques using an insulated-tip knife (IT knife) were introduced several years ago to allow en-bloc resection of early gastric cancers, since histological evaluations are essential in order to assess the risk of lymph-node metastasis [1] [2]. However, the technique requires special skills and involves a prolonged procedural time. We have therefore developed a new type of dissection knife, termed the “hood-knife” (patent pending in Japan), which only requires a simple technique.