Reversible Renal Insufficiency and Angiotensin-Converting Enzyme Inhibitor Therapy
Authors: James J. Glazier, Jeffrey W. Olin
Journal: Annals of Internal Medicine (1992)

Letters15 April 1992Reversible Renal Insufficiency and Angiotensin-Converting Enzyme Inhibitor TherapyJames J. Glazier, MD, Jeffrey W. Olin, DOJames J. Glazier, MDSearch for more papers by this author, Jeffrey W. Olin, DOSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-8-697 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Toto and colleagues (1) reported a relatively high incidence of reversible renal insufficiency (19%) in patients with hypertensive nephrosclerosis and chronic renal insufficiency treated with enalapril and "conventional" antihypertensive agents. Renal insufficiency was associated only with a significant decrease in blood pressure and did not occur in patients treated with only "conventional" antihypertensive agents. This observation makes sense physiologically and, if confirmed, will make an important contribution to the literature.A major point of contention is the investigators' proposal that enalapril may cause reversible renal insufficiency in patients with chronic renal parenchymal disease but without renal artery...References1. TotoMitchellLeeMilamPettinger RHHCW. Reversible renal insufficiency due to angiotensin-converting enzyme inhibitors in hypertensive nephrosclerosis. Ann Intern Med. 1991;115:513-9. LinkGoogle Scholar2. Working Group on Renovascular Hypertension. Detection, evaluation, and treatment of renovascular hypertension. Arch Intern Med. 1987;147:820-9. CrossrefMedlineGoogle Scholar3. OlinNovick JA. Renovascular disease. In: Young JR, Graor RA, Olin JW, Bartholomew JR, eds. Peripheral Vascular Diseases. St. Louis: Mosby Year Book; 1991:267-84. Google Scholar4. TaylorKettlerMoneta DMG. Duplex ultrasound scanning in the diagnosis of renal artery stenosis: a prospective evaluation. J Vase Surg. 1988;7:363-9. CrossrefMedlineGoogle Scholar5. Keith T. Renovascular hypertension in black patients. Hypertension. 1982;4:438-43. CrossrefMedlineGoogle Scholar1. TotoMitchellLeeMilamPettinger RHHCW. Reversible renal insufficiency due to angiotensin-converting enzyme inhibitors in hypertensive nephrosclerosis. Ann Intern Med. 1991;115:513-9. LinkGoogle Scholar1. TotoMitchellLeeMilamPettinger RHHCW. Reversible renal insufficiency due to angiotensin-converting enzyme inhibitors in hypertensive nephrosclerosis. Ann Intern Med. 1991;115:513-8. LinkGoogle Scholar2. EidtFryClagettFisherAlwayFry JRGDCW. Postop erative follow-up of renal artery reconstruction with duplex ultrasound. J Vase Surg. 1988;8:667-73. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Cleveland Clinic Foundation Cleveland, OH PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1992Volume 116, Issue 8Page: 697-698KeywordsAngiotensin converting enzyme inhibitorAntihypertensive drug therapyBlood pressureChronic kidney diseaseRenal arteriesRenal diseases Issue Published: 15 April 1992 PDF downloadLoading ...