tbuckley/cabot-search huggingface dataset:
The Hearty Perennial
Authors: JACK COULEHAN
Journal: Annals of Internal Medicine (1988)

Ad Libitum1 May 1988The Hearty PerennialJACK COULEHAN, M.D.JACK COULEHAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-5-778 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStories of the sickkeep welling up long afterit could make any difference.Take the swooning perennial.I stand still, the room beginsto shift, my stomach churns.The vertigo she sufferedtosses me soundlywhen I least expect it.Once upon a timeshe walked among the commonplace,had a breakfast of marmalade, toast,a little work in the garden.She waved after the neighborsrunning for their buses.One day she put down the trowel,intended to stand, but feltherself caterwaul. . . slowly,like a petal in a currentuntil her head hit the ground.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1988Volume 108, Issue 5Page: 778-778KeywordsRunningStomachVertigo ePublished: 1 December 2008 Issue Published: 1 May 1988 PDF downloadLoading ...
Retrograde nontransseptal balloon mitral valvuloplasty. Immediate results and long-term follow-up.
Authors: C Stefanadis, C Stratos, C Pitsavos, I Kallikazaros, F Triposkiadis, A Trikas, C Vlachopoulos, I Gavaliatsis, P Toutouzas
Journal: Circulation (1992)

Percutaneous retrograde nontransseptal balloon mitral valvuloplasty is a new technique developed in our institution for opening a stenotic mitral valve. This technique is based on a new, externally steerable cardiac catheter that enters the left atrium retrogradely via the left ventricle.The technique was used in 86 consecutive patients (18 men and 68 women; mean age, 51 +/- 11 years). Dilatation of the stenotic mitral valve was achieved in 85 of the 86 patients. After the procedure, mitral valve area increased from 0.92 +/- 0.22 to 2.14 +/- 0.54 cm2 and transmitral gradient decreased from 16 +/- 6 to 5 +/- 2 mm Hg. Major complications, such as cardiac performation, embolic events, or death, were not encountered. Severe mitral regurgitation (greater than 2+) developed in three patients (3.5%). In two patients (2.4%), there was major injury of the femoral artery. The maintenance of the initial improvement was similar to that found in studies that used transseptal techniques. The restenosis rate during the 2-year follow-up was 15.4%.The immediate and long-term findings of this study indicate that retrograde percutaneous nontransseptal balloon mitral valvuloplasty is an effective and safe procedure with an acceptable major complication rate. Moreover, this new technique has the advantage that it does not involve puncture and dilatation of the interatrial septum, although it may occasionally lead to arterial damage. Further studies will show whether it may really be considered as an alternative method or method of choice for percutaneous balloon mitral valvuloplasty.
The finger, the foot, my bone cancer
Authors: Nick Taffinder
Journal: BMJ (2005)

“I f you don't put your finger in it, you'll put your foot in it”—this is an odd thought to have at 4 am, when you're waiting to have operation number three for your bone cancer. At first glance it was a bit of an imposition. A male nurse was asking for my professional opinion on his mundane rectal symptoms—at 4 am. I was awake and anxious about my own operation in a few hours' time. He was supposed to be looking after me, not the other way round. I was on sick leave.

On the other hand he was one of those nurses you value: professional, polite, caring, and helpful. And I liked him. He was my age, just over 40. He had turned a blind eye to my using my mobile phone to stay in touch with my family. In return I had lent him my charger when his mobile ran flat. These things matter when you are an inpatient for three weeks.

I had been back at work since then. My brain had shrugged …
P3-098: Multicenter, randomized phase II trial of CI–1033, an irreversible pan– erbB inhibitor, for previously treated advanced non–small cell lung cancer
Authors: Pasi A. Janne, Joachim von Pawel, Roger B. Cohen, Lucio Crino, Charles A. Butts, Steven S. Olson, Irene A. Eiseman, Alberto A. Chiappori, Beow Y. Yeap, Peter F. Lenehan, Kathy Dasse, Meredith Sheeran, Philip D. Bonomi
Journal: Journal of Thoracic Oncology (2007)
Post-Colonoscopic Polypectomy Pneumoperitoneum Successfully Treated by Paracentesis
Authors: A. Vieira, V. Fernandes, J. Freitas
Journal: Endoscopy (2005)

Perforation is the most common complication of colonoscopy, with an incidence of 0.3 % after polypectomy [1]. The management of perforation depends on whether there is coexisting peritonitis, the timing of the diagnosis, and on the patient’s clinical condition and course, but conservative therapy is seldom indicated [1] [2] [3].
Stilbestrol and Urogenital-Tract Cancer in Adolescents and Young Adults
Authors: Brian E. Henderson, Barbara D. A. Benton, Philip T. Weaver, George Linden, James F. Nolan
Journal: New England Journal of Medicine (1973)

THE reported association between vaginal adenocarcinoma in young women and maternal stilbestrol administration1 , 2 prompted a review of the records of the California Tumor Registry. The results of this review indicated that during the period 1963–1969, there had been a relative increase in the number of cancers of the vagina, corpus uteri, prostate, testis and male bladder in the group from 10 to 19 years of age as compared to the period 1950–1962.3 Interviews have been completed on 41 of these adolescents and young adults with cancer in various urogenital-tract sites. The ages at the time of diagnosis ranged from one . . .
Torsion of the testis: why is the prognosis so poor?
Authors: T. R Terry, A. J Cook
Journal: BMJ (1987)

Population Censuses and Surveys) would not have been possible using routinely available data.It will, however, be possible using incidence data once the office has completed the postcoding of addresses in the cancer registration files (working retrospectively back to 1971).It will not be pos- sible using mortality data for the years before 1981 without a major recoding of address information.In conclusion, the Office ofPopulation Censuses and Surveys' report was not, and could not have been, a study of cancer risk among people living within two to three miles of nuclear installations.It is clear, however, from reports discussed in chapter 2 ofthe study that for some members ofthe public concern about possible risks extends at least as far as 10 miles.Data have now been presented that indicate cancer levels within these limits.'Dr Russell Jones considers the epidemiological evidence for an increase in childhood cancer in the vicinity of nuclear installations to be "consistent and compelling." In my opinion, a more balanced conclusion is that there have been some increases relating to different age groups and different distance zones in the vicinity of some installations and that there is as yet no clear evidence on what the cause of these increases might be.'-'2
Kidney Donation: Exclusion Criteria
Authors: Aaron Spital, Max Spital
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 September 1987Kidney Donation: Exclusion CriteriaAARON SPITAL, M.D., MAX SPITAL, M.D.AARON SPITAL, M.D.Search for more papers by this author, MAX SPITAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-426 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their careful review of living kidney donors, Bay and Hebert (1) list exclusion criteria used at 12 large transplant centers to prevent a person from donating a kidney. Obviously, most of these criteria are designed to protect the health of the donor. However, we have two problems with the authors' recommendations.First, although on theoretic grounds the exclusion criteria appear quite reasonable, they are unfortunately based on few data. For example, where are the data showing a greater risk for renal failure in a person with 3 as opposed to 0 to 1 erythrocytes per high-power...References1. BAYHEBERT WL. The living donor in kidney transplantation. Ann Intern Med. 1987;106:719-27. LinkGoogle Scholar2. SPITAL A. Attitudes of non-physician hospital personnel toward living kidney donation [Abstract]. Kidney Int. 1987;31:468A. Google Scholar3. SPITALSPITAL AM. Donor's choice or Hobson's choice? Arch Intern Med. 1985;145:1297-1301. CrossrefMedlineGoogle Scholar4. SPITALSPITAL AM. Kidney donation: reflections. Am J Nephrol. 1987;7:49-54. CrossrefMedlineGoogle Scholar5. KASSIRER J. Adding insult to injury: usurping patients' prerogatives. N Engl J Med. 1983;308:898-901. CrossrefMedlineGoogle Scholar1. Top 10 U.S. Transplant Centers for 1984. Contemp Dial Nephrol. 1985;Sep. Google Scholar2. Living related kidney donors [Editorial]. Lancet. 1982;2:696. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1987Volume 107, Issue 3Page: 426-426KeywordsRenal failureRenal transplantation Issue Published: 1 September 1987 PDF DownloadLoading ...
Operation for obstructive coronary disease.
Authors: G. M. FitzGibbon, G. D. Hooper, D. A. Maciver
Journal: BMJ (1969)

MEDICOHRNAL 181 heparin in clearing veins of fresh thrombus."It is true that suggestive evidence from several small series of cases has been published, but demonstration of superiority requires large-scale controlled trials, which have not been reported.Failure to mention urokinase is to be regretted.This plasminogen activator is of human origin; it is non-antigenic and relatively non-toxic.It is probably much easier with urokinase to obtain the type of biochemical state found by Johnson and McCarty' to be most effective in producing thrombolysis in man.Your leader's penultimate paragraph states "Now that the dose, route, control, and efficacy of thrombolytic therapy are becoming firmly established, this form of treatment should be part of the therapeutic armamen- tarium of all physicians and surgeons."We believe this enthusiastic advocacy to be premature, uncritical, and unjustified on currently available evidence.We regret that you have lent the weight of your authority to this advice.Dosage and control of therapy are controversial, and claims for proof of efficacy rest on clinical trial of inadequate design or of small scale; hazards and com- plications are still numerous.We believe that thrombolytic therapy may have great promise, but it must be regarded as still in the clinical investigative phase.Despite the many difficulties as discussed above, it is hoped that large-scale controlled clinical trials may soon be executed on an inter- national basis or on a national basis in this country, perhaps organized by a body such as the Medical Research Council.-We are, etc.,
Parkinson's Syndrome following Severe Herpes Ophthalmicus
Authors: G. Strong
Journal: BMJ (1952)

Parkinson's Syndrome foilowing Severe Herpes Ophthalmicus A number of papers have recently appeared in various journals on the complications of herpes zoster.These are lesions of motor neurones, myelitis and meningitis, and encephalitis.Alajouanine and Griffith (1931) record a case of a girl of 17 who developed typical signs of disseminated sclerosis two years after a "herpes myelitis."The follow- ing case of Parkinson's syndrome occurred after severe herpes ophthalmicus. CASE REPORTA flight lieutenant aged 48 had a healthy Service record of nearly 30 years, apart from gastric symptoms spread over a number of years.He first noticed slowness of movement and marked general tremor in January, 1949.There was no history of varicella, but he thought he had had measles
Visual Imagery and Cognitive Organization
Authors: MARDI J. HOROWITZ
Journal: American Journal of Psychiatry (1967)

Pictorial cognition is one of many forms of thinking in nonverbal representations. The author describes the kinds of visual imagery and the circumstances of their occurrence and enhancement, and considers the relevant problems of reality testing, content, purpose, and sequential organization. He suggests that pictorial cognition is a developmentally more primitive system than verbal-conceptual thinking and has special psychologic utility as a carrier of affectively charged memories, ideas, and impulses.
In situ immunological characterization of the infiltrating cells in positive patch tests
Authors: ELISABETH RALFKIAER, G. LANGE WANTZIN
Journal: British Journal of Dermatology (1984)

Journal Article In situ immunological characterization of the infiltrating cells in positive patch tests Get access ELISABETH RALFKIÆR, ELISABETH RALFKIÆR Departments of Pathology, The Finsen Institute, DK‐2100 Copenhagen ø, Denmark Elisabeth Ralfkiær, Department of Pathology, The Finsen Institute, 49 Strandboulevarden, DK‐2100 Copenhagen ø, Denmark. Search for other works by this author on: Oxford Academic Google Scholar G. LANGE WANTZIN G. LANGE WANTZIN Departments of Dermatology, The Finsen Institute, DK‐2100 Copenhagen ø, Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue 1, 1 July 1984, Pages 13–22, https://doi.org/10.1111/j.1365-2133.1984.tb04011.x Published: 01 July 1984 Article history Accepted: 18 January 1984 Published: 01 July 1984
Open Controlled Staffs In Accredited Hospitals
Authors: Otto Arndall
Journal: JAMA (1967)

<h3>To the Editor:—</h3> To avoid pitfalls of misconception, and to prepare for anticipated changes, the following letter was addressed to the Joint Commission on Accreditation of Hospitals. We were much pleased with the content and spirit of their reply to a letter sent on behalf of the Board of Trustees of the Medical Society of Mobile County, and think it deserves suitable presentation. The writer urges the Joint Commission Accreditation of Hospitals to exercise its jurisdictional powers toward sustaining open staffs. We have sustained several generations of local physicians enjoying multiple staff privileges. There has been evidence that inspectors and reports on inspections of the reviewing authorities look askance at this practice. Not only do we urge that this practice not be abolished, we even seek to remind those who seem not to be privileged in this respect that it has many measurable advantages, sustaining and improving the practice of
Abstract 1660: Therapeutic targeting cross talk between ROS/autophagy and apoptosis for pancreatic cancer by a herbal extract.
Authors: Gong Jingjing, Addanki P. Kumar
Journal: Cancer Research (2013)

Abstract 5-year survival for pancreatic cancer (PanCA) continuous to be lower than any other solid tumor due to late stage diagnosis combined with lack of effective therapeutic options. Therefore developing novel strategies possibly based on molecular targets is critical for successful management of PanCA. Recent studies from our laboratory show potential anti-pancreatic cancer activity for NexrutineR (Nx), a bark extract isolated from traditional Chinese medicine Phellodendron amurense. These studies also show that Nx reduces pancreatic fibrosis in preclinical animal model through targeting two critical oncogenic transcription factors including NF-κB and Stat3. Nonetheless, the precise molecular mechanism associated with the observed biological activity is unclear. We investigated whether Nx inhibits pancreatic cell proliferation and pancreatic fibrosis via reactive oxygen species (ROS)-mediated activation of autophagy. Our data show that Nx can induce autophagy at earlier time points (4h) but inhibit autophagy at later time points (24h) in human pancreatic cancer cell lines Capan-2 and BxPC-3 as evidenced by autophagosome formation, alteration in the expression and levels of various autophagy related genes. Interestingly Nx also induced apoptosis at 24h time point but not at 4h suggesting that autophagy precedes apoptosis. Further under these experimental conditions, treatment of pancreatic cancer cells with Nx enhanced intracellular production of ROS implicating a cross talk between Nx-induced ROS, autophagy and apoptosis. Overall, our findings divulge an important role for ROS/autophagy/apoptosis in Nx-mediated anti-pancreatic cancer effects. Supported by NCCAM (APK). Citation Format: Gong Jingjing, Addanki P. Kumar. Therapeutic targeting cross talk between ROS/autophagy and apoptosis for pancreatic cancer by a herbal extract. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1660. doi:10.1158/1538-7445.AM2013-1660
Abstract 1008: Concomitant HDAC and PI3K-AKT pathway inhibition as a new therapeutic strategy for prostate cancer.
Authors: Sheng-Yu Ku, Roberto Pili, Leigh Ellis
Journal: Cancer Research (2013)

Abstract Background: Prostate cancer (PCa) is the most prevalent cancer in men in the United States. Prostate cancer patients that progress to a lethal phenotype are currently treated with chemotherapy, second generation androgen therapies and immunotherapy. Unfortunately, patient response is not often durable; therefore novel treatments are urgently needed. Histone deacetylases (HDACs) have shown to be up-regulated in PCa. Preclinical data indicates that HDAC inhibitors induce apoptosis in androgen receptor (AR)-positive cells. Unfortunately, HDACi display minimal clinical benefit. From this, we propose that combination of HDACi with novel targeted therapies will result in greater therapeutic efficacy. Methods: PC3, PC3AR and PtenCaP8 PCa cell lines treated with panobinostat (HDACi) and BEZ235 (PI3K-mTORC1 inhibitor) as single treatment or in combination for 48 hours. Cell death/apoptosis was assessed by loss of cell membrane integrity, phosphotidylserine exposure, cell cycle and caspase activation by flow cytometry. Expression levels of activated AKT were assessed by immunoblot. Results: Panobinostat induces cell death/apoptosis greater in PC3AR than parental PC3 cells by increasing subG1 population (47.8±9.3 vs. 11.1±2.8,), phosphotidylserine exposeure (41.4±3.0 vs. 21±7.2,) and caspase activation (57.3±0.9 vs. 12.0 ±4.1,) respectively. Moreover, PC3AR cells treated with panobinostat results in loss of AKT activation, but not in PC3 cells. Further, combination of panobinostat with BEZ235 increases greater cell apoptosis in PC3AR cells compared to panobinostat single agent (30.6±1.9 vs. 19.9±1.4) and in PtenCaP8 cells (42.0±6.5 vs. 29.4±2.2). Western blotting also shows that combination treatment leads to loss of AKT activation compared to panobinostat and BEZ235 as a single agent. Conclusions: Overall, our results suggest that inhibition of HDACs induces greater cell death associated with loss of AKT activation in AR-positive cells, but not in AR-null cells. Also, combination of HDAC inhibitor and PI3K-mTORC1 inhibitor has more effective cell cytotoxicity compared to single agent, suggesting that inhibition of HDACs and PI3K-mTORC1 will exhibit greater therapeutic efficacy. In future work, combination of panobinostat with BEZ235 will be investigated in preclinical animal models to propose this therapy combination for clinical trials in patients with lethal PCa. Citation Format: Sheng-Yu Ku, Roberto Pili, Leigh Ellis. Concomitant HDAC and PI3K-AKT pathway inhibition as a new therapeutic strategy for prostate cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1008. doi:10.1158/1538-7445.AM2013-1008
Possible Role of Malaria in the Aetiology of the Nephrotic Syndrome in Nairobi
Authors: P. H. Rees, R. D. Barr, P. E. Cordy, A. Voller
Journal: BMJ (1972)

In a study in Nairobi, Kenya, 30 young adults with nephrotic syndrome were investigated in detail and a further 18 were studied less completely. In no case was evidence found to support a possible role for malaria in the aetiology of the syndrome.
Involvement of chymase-mediated angiotensin II generation in blood pressure regulation
Authors: Ming Li, Ke Liu, Jan Michalicek, James A. Angus, John E. Hunt, Louis J. Dell’Italia, Michael P. Feneley, Robert M. Graham, Ahsan Husain
Journal: Journal of Clinical Investigation (2004)

Angiotensin I–converting enzyme (ACE) inhibitors are thought to lower blood pressure in hypertensive patients, mainly by decreasing angiotensin II (Ang II) formation. Chymase, a human mast cell protease, has recently been proposed to play a role in blood pressure regulation because of its Ang II–forming activity. Here we show that the predominant chymase mRNA species in the mouse aorta are those for types 4 and 5 isoforms, and that both are efficient Ang II–forming enzymes. Evaluation of ACE-dependent and ACE-independent Ang II–forming pathways in mast cell–deficient (Kitw/Kitw-v) mice and their mast cell–sufficient littermate (MC+/+) controls revealed that, in contrast to the latter, Kitw/Kitw-v mice fail to express chymase mRNAs in the vasculature and have almost no ACE-independent Ang II–forming activity in either isolated blood vessels or homogenates. Moreover, in MC+/+ but not in Kitw/Kitw-v mice, a contribution of ACE-independent Ang II generation to blood pressure regulation was evident by a 1.6-fold greater maximal reduction in mean arterial pressure with acute ACE inhibition plus AT1 receptor blockade than with ACE inhibition alone. Thus, mast cells are the source of the vascular ACE-independent pathway, and the antihypertensive benefit of combining ACE inhibitor therapy with AT1 receptor antagonist therapy is most likely due to negation of chymase-catalyzed Ang II generation.
Of Genes and Men: The Alternative View of Sex Differences in Cystic Fibrosis
Authors: Erika J. Sims, Jonathan McCormick, Anil Mehta
Journal: Diabetes Care (2006)

We thank Creus et al. (1) for their interesting comments on our proposal that female subjects with cystic fibrosis–related diabetes develop worse lung function compared with age- and genotype-matched male peers. They ask whether these differences are a result of “evolutionary, sex-specific selective pressures.” They then make the assertion that cystic fibrosis heterozygosity must “simultaneously place an enormous selective pressure against men carrying these same ‘infertility’ alleles even in heterozygosity.” The difficulty we face in …
Referrals to an "early synovitis clinic": are they appropriate?
Authors: P A COURTNEY
Journal: Annals of the Rheumatic Diseases (2001)

There is mounting evidence that early disease modifying treatment improves the outcome in patients with rheumatoid arthritis (RA)1 and that treatment should begin before the disease is established and irreversible damage has occurred.2 This evidence has led to the development of “early synovitis clinics” in many rheumatology units to fast track appropriate patients. Early referral for specialist advice has been shown to be associated with improved health and physical function, with the concept of early treatment of RA shortening observation periods before referral in general practice.3 A shortened observation time is important as Irvine et al showed that 73% of patients waiting more …