tbuckley/cabot-search huggingface dataset:
THE EFFECTS OF LOCAL COOLING ON THE CUTANEOUS BLOOD FLOW IN NORMAL AND ERYTHROCYANOTIC PATIENTS.
Authors: A. JARRETT, M. GARRETTS
Journal: British Journal of Dermatology (1959)

Journal Article THE EFFECTS OF LOCAL COOLING ON THE CUTANEOUS BLOOD FLOW IN NORMAL AND ERYTHROCYANOTIC PATIENTS. Get access A. JARRETT, A. JARRETT Research Assistant Search for other works by this author on: Oxford Academic Google Scholar M. GARRETTS M. GARRETTS Senior Registrar, Dermatological Department, University College Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 71, Issue 2, 1 February 1959, Pages 66–71, https://doi.org/10.1111/j.1365-2133.1959.tb13387.x Published: 01 February 1959
Advances in Skin Regeneration: Application of Electrospun Scaffolds
Authors: Mohammad Norouzi, Samaneh Moghadasi Boroujeni, Noushin Omidvarkordshouli, Masoud Soleimani
Journal: Advanced Healthcare Materials (2015)

The paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin substitutes and wound dressings. Furthermore, the application of biomolecules and therapeutic agents in the nanofibrous scaffolds viz growth factors, genes, antibiotics, silver nanoparticles, and natural medicines with the aim of ameliorating cellular behavior, wound healing, and skin regeneration are discussed.
Effect of Pseudo-cholinesterase Level on Action of Succinylcholine in Man
Authors: F. T. Evans, P. W. S. Gray, H. Lehmann, E. Silk
Journal: BMJ (1953)

RELAXANTS DERIVED FROM SUCCINIC ACID 1MMCMJORk cholinesterase available.However, it should be possible to increase the pseudo-cholinesterase of the plasma in the dog and thus to lower the concentration of free succinylcholine or suxethonium so rapidly that even the low concentration of the drug required for inhibition of the true cholinesterase in that animal will be effectively attacked.We therefore injected a highly concentrated solution of pseudo-cholin- esterase intravenously into four dogs in the course of opera- tions for mastectomy or conditions requiring orthopaedic treatment, and compared the effect of equal amounts of suxethonium given before and after the pseudo-cholin- esterase level of the plasma had been increased.As will be seen in Table III, after the pseudo-cholinesterase had been effectively raised succinylcholine was as short-acting in dog as it is known to be in man.To exclude the effects of premedication and the possibility that apnoea was due to artificial hyperventilation, one experiment was performed in which only thiopentone was used for induc- tion and no artificial respiration was given during apnoea beyond one inflation per minute.Table IV shows that the TABLE IV.-Adult Mongrel Bitch, Weight 31 lb.(14 kg.) 0 min. 0-5g. thiopentone Recording apparatus for blood pressure and respiratory rate connected 18 ,, 01 g. thiopentone Pseudo-cholinesterase, 46; true cholinesterase, 18 23 ,, 3 5 mg.suxethonium: 16 min.apnoea 43 ,, 0-1 g. thiopentone 48 3-5 mg.suxethonium: 11 min.apnoea 70 2 mg.succinylcholine: 5 min.apnoea 83 ,, 01 g. thiopentone 93 ,,injection of 21,000 units pseudo-cholinesterase 97 Pseudo-cholinesterase, 76; true cholinesterase, 15-5 102 3-5 mg.suxethonium: no apnoea, 3 min.respiratory depres- sion 112 ,,3-5 mg.
Toward an Integrated Approach to the Treatment of Schizophrenia
Authors: Marvin I. Herz
Journal: Psychotherapy and Psychosomatics (1986)

Long-term outcome studies have shown that schizophrenia is an illness whose course is usually characterized by exacerbations and remissions. This chapter summarizes pertinent literature regarding treatment of acute episodes; early intervention to prevent the development of full relapse; and pharmacological, behavioral, and psychotherapeutic strategies designed to decrease the amount of stress and patients' vulnerability to stress and thus decrease the likelihood of relapse. An emphasis is placed on a comprehensive treatment approach involving continuity of care.
Cardiac Arrest vs Extreme Bradycardia
Authors: Reuben Tizes
Journal: JAMA (1978)

To the Editor.—  An inquiry was recently made by Stern and Keren (239:403, 1978) as to whether a reported cardiac arrest following routine venipuncture (236:1846,1976) was instead an extreme case of sinus bradycardia. Stern and Keren attempt to compare a reported asymptomatic patient who sustained a cardiac arrest following routine venipuncture in an outpatient office setting with their experience with a patient who lost consciousness after a routine venipuncture in their Coronary Care Unit. In reviewing their case report, one notices that their patient was admitted to the Coronary Care Unit with a history of chest pain and, while his ECG was being constantly monitored, went into extremely slow sinus rhythm after a routine venipuncture and responded well to intravenous atropine.  One cannot, in all fairness, compare these two patients for a variety of reasons, such as presence of chest pains and ECG monitoring. The most important issue facing a
Associations of postmenopausal estrogen use with cardiovascular disease and its risk factors in older women. The CHS Collaborative Research Group.
Authors: T A Manolio, C D Furberg, L Shemanski, B M Psaty, D H O'Leary, R P Tracy, T L Bush
Journal: Circulation (1993)

BACKGROUND Postmenopausal estrogen replacement therapy has been associated with favorable levels of cardiovascular disease risk factors, but these associations and the relations between estrogen use and subclinical disease have not been examined in large samples of older women. METHODS AND RESULTS Present and past estrogen use was ascertained in 2955 women &gt; or = 65 years old in the Cardiovascular Health Study, a study of risk factors for coronary heart disease and stroke in the elderly. Present estrogen use was reported by 12% of these women and past use by an additional 26.5%. Estrogen use (past or present) was strongly associated with lower low-density lipoprotein cholesterol, fibrinogen, glucose, insulin, obesity, and age and higher high-density lipoprotein cholesterol and socioeconomic status (all P &lt; .0001). Estrogen users also had lower levels of subclinical disease as measured by carotid intimal-medial thickness, carotid stenosis grade, ECG left ventricular mass, and Doppler mitral peak flow velocities (each P &lt; .02). Relations were similar in younger and older women (65 to 74 versus &gt; or = 75 years) and smokers and nonsmokers and were unchanged after women with poor medication compliance were excluded. After adjustment for other factors, estrogen use was associated with decreased carotid wall thickness, although this association was of borderline significance after further adjustment for lipids. CONCLUSIONS Postmenopausal estrogen use in this sample of older women was associated with favorable cardiovascular disease risk factor profiles and with lower measures of subclinical disease. These findings suggest that postmenopausal estrogen use may be associated with lower risk of cardiovascular disease in women well into the eighth decade of life.
Is estimating lifetime cardiovascular risk useful?
Authors: R. Jackson, A. Kerr, S. Wells
Journal: BMJ (2010)

One of the exercises we set our medical students when introducing clinical epidemiology is to present the risk profile of a middle aged man and ask them to estimate his risk of death. Eventually someone works out the answer—100%. Death is inevitable, it is when and how the patient dies that are important. So does the QRISK lifetime cardiovascular risk model described in the linked study by Hippisley-Cox and colleagues (doi:10.1136/bmj.c6624) have any more clinical relevance than the lifetime risk of death?
Direct Myocardial Effects of OPC-18790 in Human Heart Failure: Beneficial Effects on Contractile and Diastolic Function Demonstrated by Intracoronary Infusion With Pressure–Volume Analysis
Authors: Guy A MacGowan, Howard L Haber, T.Douglas Cowart, Christine Tedesco, Clarence Wu, Marc D Feldman
Journal: Journal of the American College of Cardiology (1998)
Randomized Controlled Trial of Topical Hyperbaric Oxygen for Treatment of Diabetic Foot Ulcers
Authors: Camilo A Leslie, Francisco L Sapico, Virginia J Ginunas, Rodney H Adkins
Journal: Diabetes Care (1988)

The effect of 2 wk of topical hyperbaric oxygen (THO) treatment on the healing of diabetic foot ulcers without associated gangrene was evaluated in a prospective, controlled, and randomized manner in 28 patients. There were 12 patients in the THO group (group 1) and 16 in the control group (group 2). Clinical management of the two patient groups was similar except for THO treatment in the group 1 patients. Clinical parameters, including age, sex, baseline fasting serum glucose levels, duration of diabetes mellitus, duration of foot ulcers, presence of peripheral neuropathy or arterial insufficiency, and evidence of osteomyelitis as determined by radiographs and/or radionuclide scans, were comparable in both groups of patients. No statistical differences (Student's t test) were seen in the number of microorganisms isolated from curettage cultures of the base of the ulcer at days 0, 7, and 14 of the study between groups 1 and 2. In contrast to previous studies, there was a paucity of anaerobic microorganisms isolated from these foot ulcers without associated gangrenous changes. Ulcer areas were estimated by multiplying the maximum width by the maximum length in millimeters at days 0, 7, and 14. Analysis of variance and Student's t test revealed progressive significant reductions in the ulcer areas in both groups when days 0, 7, and 14 were compared and in ulcer depths in both groups when days 0 and 14 were compared. However, such ulcer size changes did not differ statistically between the control and THO groups. A trend toward slower healing was observed in the From the THO group. Healing of diabetic foot ulcers was not accelerated by THO in this study.
SC-29 * THERAPEUTIC POTENTIAL OF A NEWLY DISCOVERED NEURAL LIKE STEM CELL
Authors: A. Sattiraju, A. Birbrair, D. Zhu, I. Batista, O. Delbono, A. Mintz
Journal: Neuro-Oncology (2014)

Glioblastoma (GBM) is an aggressive primary brain tumor with a dismal prognosis. However, due to their tumor-tropic migratory capacity, stem cells are emerging as feasible delivery vehicles to therapeutically target primary and invasive tumor cells. However, this approach faces a number of hurdles, including: (1) the potential tumorigenic and cancer propagating capacity of pluripotent cells; and (2) the inability to obtain certain autologous stem cells. Therefore the goal of this work is to establish the therapeutic potential of a newly discovered neural-like stem cell (NLSC) that we derived peripherally from a unique pericyte that we identified. Importantly, we found that NLSC possess similar characteristics as NG2-glia. We tested the tumor tropism of NLSCs in vitro using a transwell assay and found that they preferentially migrated towards conditioned media. Furthermore, we demonstrated that our NLSCs migrated directionally towards orthotopic GBMs in vivo. We also demonstrated the potential on NLSCs to artificially secrete a prototype therapeutic (TRAIL) and kill adjacent GBM cells in vitro. Importantly, when implanted orthotopically or subcutaneously for extended periods of time (> 4 weeks), NLSCs did not form tumors. To test if these NLSCs contributed to tumor progression, we tested their ability to support angiogenesis and transform into tumor associated fibroblasts (TAFs). Using both an in vitro endothelial tube formation assay and an in vivo matrigel plug assay, we found that NLSCs did not support angiogenesis, in contrast to MSCs. To test if our NLSCs transformed into TAFs, we exposed them to TGF-β and observed that only MSCs, but not NLSCs transformed into TAFs demonstrated by the expression of α-SMA and collagen type-1, both characteristic of fibroblast lineage. Based on these findings, NLSCs represent a novel promising peripherally derived source of stem cells that can potentially safely be used to deliver therapeutics to GBM.
Rheumatoid arthritis association at 6q23
Authors: Wendy Thomson, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N Bruce, Anthony G Wilson, Ioanna Marinou, Ann Morgan, Paul Emery, Angela Carter, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille Harrison, David Strachan, Jane Worthington
Journal: Nature Genetics (2007)
CASTE AND MENTAL DISORDERS IN BIHAR
Authors: SHARADAMBA RAO
Journal: American Journal of Psychiatry (1966)

From 10 major Hindu communities—Brahmin, Bhumihar, Bania, Rajput, Goala, Kurmi, Kayastha, Koiri, Teli and scheduled castes—2310 first admissions to the public mental hospital in Bihar during the years 1959-60 reveal that the higher castes predominate. Schizophrenia as compared to affective disorder is conspicuous among the Brahmin and Kayastha patients. This reflects not only the influence of education on the recourse to hospitalization in the event of a mental breakdown but also factors associated with such incidence. The rate of admission of the female patients is higher among the Kayastha patients. Also, single patients, compared to the married are conspicuous among the Kayastha patients. The Kayastha and Bania patients are conspicuously admitted from urban areas and are also associated with a higher economic status. The educational level is comparatively higher among the Brahmin patients. Among a majority of the communities, patients in the eldest sibling position are very conspicuous.
Action of centrally mediated autonomic stimulation on human upper gastrointestinal transit: a comparative study of two stimuli.
Authors: J D O'Brien, D G Thompson, W R Burnham, J Holly, E Walker
Journal: Gut (1987)

Two well established experimental stressors, hand immersion in cold water, and mental stimulation with dichotomous listening, were applied to 37 normal subjects after the ingestion of a standard meal. Orocaecal transit was measured by serial exhaled breath hydrogen sampling. Cold water significantly delayed transit compared with warm water control (warm water 71.8 +/- 3.6 mins v cold water 93.2 +/- 5.7 mins p less than 0.01), with significant rises in blood pressure pulse rate perceived discomfort and plasma catecholamines. In contrast mental stimulation was unaccompanied by any change in transit (control; 67.4 +/- 4.7 v test 64.3 +/- 5.3 mins p greater than 0.1) despite a significant rise in pulse rate, skin conductance and plasma catecholamines. Repeated cold water immersion studies in eight individuals produced consistent orocaecal transit and autonomic responses, whereas mental stimulation showed reduced autonomic responses on repeat testing, suggesting that tolerance to the stimulus had occurred. The results of these studies show stimulus specific gastrointestinal response patterns to autonomic stimuli, and appear to have important implications for the design of future studies of human gastrointestinal autonomic physiology and for the investigation of patients with stress related gut dysfunction.
Pencil cells and prekeratocytes in iron deficiency anemia
Authors: Alexandra M. Harrington, Steven H. Kroft
Journal: American Journal of Hematology (2008)

American Journal of HematologyVolume 83, Issue 12 p. 927-927 Morphology UpdateFree Access Pencil cells and prekeratocytes in iron deficiency anemia† Alexandra M. Harrington, Alexandra M. Harrington Department of Pathology, Medical College of Wisconsin, Milwaukee, WISearch for more papers by this authorSteven H. Kroft, Corresponding Author Steven H. Kroft skroft@mcw.edu Department of Pathology, Medical College of Wisconsin, Milwaukee, WIDepartment of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226Search for more papers by this author Alexandra M. Harrington, Alexandra M. Harrington Department of Pathology, Medical College of Wisconsin, Milwaukee, WISearch for more papers by this authorSteven H. Kroft, Corresponding Author Steven H. Kroft skroft@mcw.edu Department of Pathology, Medical College of Wisconsin, Milwaukee, WIDepartment of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226Search for more papers by this author First published: 08 September 2008 https://doi.org/10.1002/ajh.21283Citations: 4 † Conflict of interest: Nothing to report. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume83, Issue12December 2008Pages 927-927 ReferencesRelatedInformation
Interactions between environmental and prothrombotic genetic risk factors in young survivors of myocardial infarction
Authors: P.A. Merlini, D. Ardissino, R. Fetiveau, M. Tubaro, M. Galvani, F. Ottani, E. Sacchi, F. Duca, PM. Mannucci
Journal: Journal of the American College of Cardiology (1998)
Use of Pyridoxine in Chorea
Authors: GEORGE W. PAULSON
Journal: American Journal of Psychiatry (1971)

Dyskinesias secondary to L-dopa often appear similar to Huntington`s disease and to the tardive dyskinesias that are associated with prolonged use of phenothiazines. Pyridoxine can reverse dyskinesias and benefits of L-dopa. A group of patients with Huntington's disease or tardive dyskinesias was treated with pyridoxine, but no change in their movements was observed. The author concludes that pyridoxine does not ameliorate these two conditions.
Characterization of indoor particle sources: A study conducted in the metropolitan Boston area.
Authors: E Abt, H H Suh, G Allen, P Koutrakis
Journal: Environmental Health Perspectives (2000)

An intensive particle monitoring study was conducted in homes in the Boston, Massachusetts, area during the winter and summer of 1996 in an effort to characterize sources of indoor particles. As part of this study, continuous particle size and mass concentration data were collected in four single-family homes, with each home monitored for one or two 6-day periods. Additionally, housing activity and air exchange rate data were collected. Cooking, cleaning, and the movement of people were identified as the most important indoor particle sources in these homes. These sources contributed significantly both to indoor concentrations (indoor-outdoor ratios varied between 2 and 33) and to altered indoor particle size distributions. Cooking, including broiling/baking, toasting, and barbecuing contributed primarily to particulate matter with physical diameters between 0.02 and 0.5 microm [PM((0.02-0.5))], with volume median diameters of between 0.13 and 0.25 microm. Sources of particulate matter with aerodynamic diameters between 0.7 and 10 microm [PM((0.7-10))] included sautéing, cleaning (vacuuming, dusting, and sweeping), and movement of people, with volume median diameters of between 3 and 4.3 microm. Frying was associated with particles from both PM((0.02-0.5)) and PM((0.7-10)). Air exchange rates ranged between 0.12 and 24.3 exchanges/hr and had significant impact on indoor particle levels and size distributions. Low air exchange rates (< 1 exchange/hr) resulted in longer air residence times and more time for particle concentrations from indoor sources to increase. When air exchange rates were higher (> 1 exchange/hr), the impact of indoor sources was less pronounced, as indoor particle concentrations tracked outdoor levels more closely.
A British Medical Association Lecture ON THE WASTING INFANT
Authors: R. Hutchison
Journal: BMJ (1924)

THE terms malnutrition, dystrophy, atropiy, atlhrepsia, " food disorders of infancy," and marasmus, are used more or less indiscriminately in textbooks to designate that condition which is familiar to all of you under the simple name of " wasting."There is iio need to describe in detail the clinical characteristics of the wasting infant; they are, unfortunately, only too familiar, although I think one may truthfully say for our comfort that the severe *degrees of wasting are not so often met with as they use(d -to be.None the less, the condition in greater or less degree is still common enough and is a source of great trouble and anxiety in practice. CAUSES OF WASTING.In order to have any success in the treatment of wasting it is important to realize that it may lhave many different causes, which may be classified as follows:1. Organic Disease.Any organic disease, of course, is apt to be attended by wasting as one of its consequences, but we are now concerned only with those cases in which the wasting is what is sometimes called the " presenting symptom," and the signs of organic disease are inconspicuous or even altogether absent.Naturally one thinks first of that great wasting disease of childhood-tuberculosis.It must be remembered, how- ever, that tuberculosis is not, as a matter of fact, commoni during the first six montlhs of inifanc, when wastinig usually occurs.Nor is it likely to occur without producing some evidence of its presence in the shape of physical signs in the chest, abdomen, or glanids, althoiugh occasionally, one must admit, it is found after death when its presen'ce had not been suspected during life.In these cases, however, one may be dealing with a secondary infection.Tubereculosis is most to be suspected when there are no signs of digestive derangement and when the rectal temperature is persistently raised.
Discordant CD4 and Viral Load Responses to Antiretroviral Therapy
Authors: N. Premchand, J.W.T. Elston, Y. Taha, M.H. Snow, D. Saunders, M. Pearce, D.A. Price, N. Premchand, C.E. Taylor, E.L.C. Ong, M.L. Schmid
Journal: Journal of Infection (2007)
American Medical Association Patient Medication Instruction (PMI) Program
Authors: Albert W. Helmeczi
Journal: JAMA (1983)

To the Editor.—  I would like to comment on the recent editorial by Dr James Sammons entitled Written Instructions and Patient Compliance (1982;248:2890). The concept of the American Medical Association patient medication instruction (PMI) program is commendable. Patients need to have information about prescription medication, and access to this information is a right of patients. However, PMI is a concept that is new only to physicians. Pharmacists have been providing and will continue to provide patients with appropriate drug information. The American Society of Hospital Pharmacists published the first edition of itsMedication Teaching Manual: A Guide for Patient Counselingin 1978. The manual contains approximately 200 drug monographs, especially designed to be reproduced and distributed to patients. This private-sector initiative was developed to provide patients with supplementary written instructions for prescription medications with the aim of improving compliance.  What concerns me the most about Dr Sammons' editorial is his