tbuckley/cabot-search huggingface dataset:
Sudden infant death syndrome among Asians in Britain
Authors: I S Farooqi, G Y H Lip, D G Beevers
Journal: BMJ (1994)

Tender points in fibromyalgia EDrroR,-Peter Croft and colleagues contend that tender points in fibromyalgia are associated with depression.'This conclusion is based on their use of the 12 item general health questionnaire as a measure of depression.This questionnaire, how- ever, is not a screening instrument for depression; it is used to detect psychiatric disorder, which can include depression, anxiety, and psychotic dis- orders.2The findings obtained with the general health questionnaire are consistent with the conclusion that tender points are associated with psychiatric disorder.This is consistent with the main point of the paper, which is that tender points are a measure ofgeneral distress.
Sensitization to <i>Blomia kulagini</i> in a general population of a subtropical region of Spain (Canary Islands)
Authors: J. C. Garcia‐Robaina, E. Eraso, J. Martinez, A. Martinez, F. de la Torre Morin, L. Hernandez‐Nieto, J. Pineda‐Algorta, J. Guisantes
Journal: Allergy (1997)

García‐Robaina JC, Eraso E, Martínez J, Martinez A, de la Torre Morin F, Hernández‐Nieto L, Pineda‐Algorta J, Guisantes J. Sensitization to Blomia kulagini in a general population of a subtropical region of Spain (Canary Islands). Allergy 1997; 52: 727–731. The Blomia genus has been described as allergenic in man. The present study aimed to assess the prevalence of B. kulagini sensitization in a large population of allergic subjects without occupational exposure in a subtropical region (Canary Islands, Spain). Secondarily, a new standardized B. kulagini extract was evaluated. The study population comprised 207 patients. RAST for B. kulagini was positive in 76.2% of patients, and 47 of them were selected for the biologic standardization. When the prick test was performed with the nonstandardized extracts, results were positive in 76.6%, whereas when the test was repeated with the standardized extract, sensitivity rose to 95.7%. The conjunctival provocation test was positive in 78.3% of 46 evaluated patients. The bronchial provocation test was positive in 18 sensitized patients and negative in five controls. In conclusion, B. kulagini is an important cause of sensitization among the occupationally unexposed population of the studied area and should be included in allergy diagnostic tests. For reliable prick tests, the use of standardized extracts is mandatory.
THE ANTECEDENTS OF ORGANIC HEART DISEASE IN CHILDREN.
Authors: FREDERICK A. PACKARD
Journal: JAMA (1900)

In every dispensary or hospital for the treatment of diseases of children, and also to almost the same extent in private practice, there are seen many cases of organic heart disease in later childhood where only few facts bearing directly on the etiology can be found. In adults the case is different, because in them many of the organic valvular defects and many of the murmurs produced by degenerative changes in the myocardium are due to wear and tear necessitated by the conditions of life. In adults also disease of the heart secondary to lesions in other organs—notably the kidneys—and to errors in metabolism is encountered more frequently than in the case of children. In childhood these factors donot enter except in occasional instances, and the occurrence of endocarditis or of myocardial changes giving rise to cardiac signs and symptoms must in them be attributed to the occurrence of infection.
A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle
Authors: Luc Grobet, Luis José Royo Martin, Dominique Poncelet, Dimitri Pirottin, Benoit Brouwers, Juliette Riquet, Andreina Schoeberlein, Susana Dunner, François Ménissier, Julio Massabanda, Ruedi Fries, Roger Hanset, Michel Georges
Journal: Nature Genetics (1997)
Why do patients with ulcerative colitis relapse?
Authors: S A Riley, V Mani, M J Goodman, S Lucas
Journal: Gut (1990)

To determine the factors responsible for ulcerative colitis relapse a cohort of 92 patients (18 to 78 years, 50 men) with clinically inactive disease have been followed for over 48 weeks. At 12 weekly intervals patients were asked, by means of standardised questionnaires, about infections, compliance with maintenance medication, new drug treatment, dietary changes, episodes of non-bloody diarrhoea, life stresses, and feelings of anxiety and depression. Thirty five patients (38%) relapsed (median interval 17 weeks, range three to 46 weeks). Patients who relapsed had a higher previous relapse rate than non-relapsers (p less than 0.001) and a shorter time from previous relapse to trial entry (p less than 0.05). Other clinical characteristics were equally matched in the two groups. Between and within group comparisons revealed that upper respiratory tract symptoms, antibiotic ingestion, analgesic intake, diarrhoeal episodes and stressful life events were no more common in the four weeks before relapse than before routine attendance. Anxiety and depression ratings were also similar in the two groups. The timing of ulcerative colitis relapse showed a clear seasonal pattern with 26 patients relapsing from August to January and only nine from January to July (p less than 0.001). In addition, a retrospective case note analysis revealed significant seasonality of onset of ulcerative colitis. We conclude that seasonal factors may contribute to both onset and relapse of ulcerative colitis.
Increased frequency (12%) of circulating chronic lymphocytic leukemia–like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach
Authors: Wendy G. Nieto, Julia Almeida, Alfonso Romero, Cristina Teodosio, Antonio López, Ana F. Henriques, Maria Luz Sánchez, María Jara-Acevedo, Ana Rasillo, Marcos González, Paulino Fernández-Navarro, Tomás Vega, Alberto Orfao
Journal: Blood (2009)
Relationship Between Tumor Size and Survival in Non–Small-Cell Lung Cancer (NSCLC): An Analysis of the Surveillance, Epidemiology, and End Results (SEER) Registry
Authors: Jianjun Zhang, Kathryn A. Gold, Heather Y. Lin, Stephen G. Swisher, Yan Xing, J. Jack Lee, Edward S. Kim, William N. William
Journal: Journal of Thoracic Oncology (2015)
Computed tomographic screening of potential complications of percutaneous pulmonary vein isolation with cryoalbation for the treatment of atrial fibrillation
Authors: Benoit Ghaye, David Szapiro, Carl Timmermans, Robert F. Dondelinger, Hung-Fat Tse, J.Christoph Geller, Gregory M. Ayers, Luz-Maria Rodriguez
Journal: Journal of the American College of Cardiology (2003)
The effect of corticotrophin and corticosteroids on the external secretion of the pancreas in dogs
Authors: W. Sircus
Journal: Gut (1961)

In acute experiments in dogs cortisone and hydrocortisone increase the concentration and output of bicarbonate in pancreatic secretion whereas prolonged administration of these hormones leads to a diminished bicarbonate response. In both acute and chronic experiments, however, cortisone and hydrocortisone produce an increased output of the enzymes amylase and trypsin.
Histological and clinical outcome after liver transplantation for hepatitis C
Authors: M C Shuhart, M P Bronner, D R Gretch, L V Thomassen, C F Wartelle, H Tateyama, S S Emerson, J D Perkins, R L Carithers
Journal: Hepatology (1997)

Hepatitis frequently recurs after liver transplantation for hepatitis C. However, the histological progression of disease, predictors of recurrence and disease severity, and patient survival remain uncertain. Fifty-five patients with cirrhosis caused by chronic hepatitis C underwent liver transplantation between January 1990 and December 1993. Hepatitis C genotype was determined, and liver biopsies were performed at frequent intervals posttransplantation. The median follow-up time was 40.4 months. The cumulative rate of survival was no different in liver transplant recipients for hepatitis C than in liver transplant recipients for other chronic liver diseases (P = .62). Histological recurrent hepatitis C developed in 33 of 50 patients assessable for disease recurrence; the median recurrence-free survival time was 13.4 months. Histological activity and stage were mild in most cases. Only 2 patients developed cirrhosis, and no patient required a second transplantation for recurrent disease. Patients with acute cellular rejection had a shorter recurrence-free survival (P = .0141). In patients with recurrent hepatitis, rejection also was correlated with increased histological grade 2 years after transplantation (P = .0061). Recurrence-free survival was decreased in patients infected with genotype 1 (1a and 1b combined) compared with genotypes 2 and 3 combined (P = .02), whereas there was no difference between genotypes 1a and 1b (P > .80). Only patients infected with genotype 1a or 1b developed bridging fibrosis or cirrhosis. In addition, patients who had an early recurrence had a greater risk of progressing to bridging fibrosis or cirrhosis (hazard ratio, 5.1; P = .0473). In our experience, recurrent hepatitiS C after liver transplantation in most cases is mild and survival is unaffected. Both acute cellular rejection and infection with genotype 1 are independent risk factors for reduced recurrence-free survival, and early recurrence is associated with a higher risk of disease progression.
Come back, Mr Chips: the decline of men
Authors: James Owen Drife
Journal: BMJ (2011)

Invited recently to give a talk on “the role of men,” I felt I had plenty to say. Men make up only a quarter of the NHS workforce. Gender politics are deterring almost all male medical students from a career in obstetrics. Television commercials are filled with feckless male stereotypes. For a lecture, though, I needed some facts that were up to date.⇑

Firstly, let’s consider men’s role in reproduction. Last September, the European Science Foundation reported that a fifth of …
P3-145: Acquired and primary resistant mutations in exon20 of the EGFR gene in NSCLC patients who were enrolled in prospective trial for gefitinib treatment
Authors: Kenji Sugio, Hidetaka Uramoto, Tsunehiro Oyama, Takamitsu Onizuka, Teruo Iwata, Tadahiro Nozoe, Mitsuhiro Takenoyama, Takeshi Hanagiri, Kosei Yasumoto
Journal: Journal of Thoracic Oncology (2007)
ASGT Advises NIH on Funding of Gene Therapy Trials
Authors: David A Williams
Journal: Molecular Therapy (2006)

As noted in our November 2006 editorial1Williams D.A NIH funding of gene therapy trials.Mol. Ther. 2006; 14: 607Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar, an ad hoc American Society of Gene Therapy (ASGT) committee appointed by Theodore Friedmann and led by Arthur Nienhuis has studied the complicated issue of NIH funding of gene therapy trials. The recommendations of this committee have been adopted by the ASGT Board of Trustees and have now been sent to the leadership of the NIH and to at least eleven NIH Institute Directors.
Association vs Causation
Authors: Mitchell R. Zavon
Journal: JAMA (1976)

<h3>To the Editor.—</h3> It is unfortunate that we do not have as yet an animal model for studying chemicals that are presumed to cause aplastic anemia or other hematopoietic defects. It is difficult, therefore, to understand the conclusion by Dr Vodopick in her clinical report entitled "<i>Cherchez la Chienne</i>" (234:850, 1975). Despite her statement that "exposure to a chemical known to produce this effect is strong circumstantial evidence that it is the culprit," there is no evidence that y-benzene hexachloride causes bone marrow hypoplasia. There have been some reports of association with exposure to γ-benzene hexachloride, just as there have been reports of association with exposure to numerous other chemicals. Unfortunately, an association, particularly of this low order of magnitude, is of little value in coming to a conclusion as to causation. There is a common misconception that the benzene ring automatically must be looked on with suspicion as a
Antitrust Law and the Physician Entrepreneur
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1985)

In a recent editorial,1 I discussed the growing trend toward entrepreneurialism among practicing physicians and urged that all sectors of organized medicine issue, as a "statement of conscience," a recommendation that practitioners divorce themselves from any financial interest in the medical marketplace. Arguments for and against such a policy were considered, but one major aspect of the problem was not. In this issue, a Special Report2 by L. Barry Costilo, a lawyer with the Federal Trade Commission (FTC), focuses our attention on that question: Would this kind of ethical code run afoul of antitrust law as it is now construed . . .
SIMPLE ULCER OF THE BLADDER.
Authors: GEORGE WALKER
Journal: JAMA (1907)

Relatively few well-described instances of simple ulcer of the bladder have been recorded, but these are sufficient to establish the existence of such a condition. It may be defined as a single non-inflammatory ulcer located in the mucous membrane of the bladder, which occasionally penetrates the entire wall. The condition is probably caused by a local disturbance in, or complete blocking of, the terminal arteries or by an interference with the trophic nerves. Infection of the bladder never produces it. It resembles in appearance a gastric ulcer and probably has a somewhat similar etiology. I have observed two cases, the histories of which are as follows: <h3>Case 1.</h3> —A man, aged 54, previous health excellent; had a mild attack of gonorrhea 8 years ago, no complications. <h3>Present Illness.</h3> —For eight months he has suffered from a slightly increased frequency of micturition, attended by burning and discomfort. Very frequently during the
B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events.
Authors: S N Liossis, B Kovacs, G Dennis, G M Kammer, G C Tsokos
Journal: Journal of Clinical Investigation (1996)

To understand the molecular mechanisms that are responsible for the B cell overactivity that is observed in patients with SLE, we have conducted experiments in which the surface immunoglobulin (sIg)-mediated early cell signaling events were studied. The anti-sIgM-mediated free intracytoplasmic calcium ([Ca2+]i) responses were significantly higher in SLE B cells compared with responses of normal individuals and to those of patients with other systemic autoimmune rheumatic diseases. The anti-IgD mAb induced [Ca2+]i responses were also higher in lupus B cells than in controls. The magnitude of anti-sIgM-mediated Ca2+ release from intracellular stores was also increased in B cells from SLE patients compared with normal controls. The amount of inositol phosphate metabolites produced upon crosslinking of sIgM was slightly higher in patients with lupus than in normal controls, although the difference was not statistically significant. In contrast, the degree of anti-sIgM-induced protein tyrosine phosphorylation was obviously increased in lupus patients. Our study demonstrates clearly for the first time that SLE B cells exhibit aberrant early signal transduction events, including augmented calcium responses after crosslinking of the B cell receptor and increased antigen-receptor-mediated phosphorylation of protein tyrosine residues. Because the above abnormalities did not correlate with disease activity or treatment status, we propose that they may have pathogenic significance.
The effect of noradrenaline, adrenergic blocking agents, and tyramine on the intrarenal distribution of blood flow in the baboon
Authors: L. BOMZON, C. ROSENDORFF, D. R. L. SCRIVEN, J. FARR
Journal: Cardiovascular Research (1975)

The intrarenal distribution of blood flow in the baboon was measured using the 133xenon clearance technique, and dose-response curves for the various components of renal blood flow were determined during intra-arterial infusions of noradrenaline; the alpha-adrenergic blocking agent, phenoxybenzamine; the beta-adrenergic blocking agent, propranolol; and tyramine which causes the release of endogenous NA. High doses of noradrenaline reduced flow in the outer cortex; this effect was attenuated by phenoxybenzamine, but not by propranolol. Tyramine had no effect. These r results suggest that there are alpha-adrenergic receptors in the resistance vessels of the kidney but are inconsistent with an important role for NA-mediated autonomic control of renal blood flow.
Return of Equipment to the Pharmacy
Authors: Virginia Bates Johnson
Journal: JAMA (1983)

To the Editor.—  In their article entitled Intravenous Antibiotic Therapy in an Outpatient Setting (1982; 248:336), Dr Poretz and colleagues state: At the end of therapy, excess  was returned and its cost deducted from the final bill.  As a practicing pharmacist in California, subject to the law that forbids return ofanyprescription merchandise, I am appalled at the idea that equipment (medications? intravenous apparatus?) is returned to a pharmacy from an environment where patients—suffering from infectious diseases—have handled it.
The details of food-sharing interactions – their cost in social prestige
Authors: Amotz Zahavi
Journal: Behavioral and Brain Sciences (2004)

I agree with Gurven that costly signaling can explain food-sharing phenomena. However, costly signaling may also explain the role of food sharing in deterring rivals. Details of food-sharing interactions may reveal gains and losses in the social prestige of the interacting parties. The evolutionary models of kin selection and of reciprocal altruism are unstable and should be avoided.
Methotrexate in Corticosteroid-Resistant Urticaria
Authors: Martin J. Weiner
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 May 1989Methotrexate in Corticosteroid-Resistant UrticariaMartin J. Weiner, MDMartin J. Weiner, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-10-848_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In recent years methotrexate has been used with varying degrees of success in a host of conditions other than neoplastic disorders. Severe psoriasis, primary biliary cirrhosis (1), sclerosing cholangitis (2), corticosteroid dependent asthma (3), and rheumatoid arthritis (4) are among the diverse conditions treated with some success with methotrexate.To my knowledge this is the first report describing probable benefit of methotrexate in longstanding acute and chronically debilitating urticaria of unknown cause which had become corticosteroid unresponsive over a 24-year period.A 48-year-old, otherwise healthy male attorney, presented in April 1988 with a 24-year history of urticaria...References1. Kaplan M, Knox T, and Arora S. Primary biliary cirrhosis treated with low-dose oral pulse methotrexate. Ann Intern Med. 1988;109:429-31. LinkGoogle Scholar2. Kaplan M, Arora S, and Pincus S. Primary sclerosing cholangitis and low-dose oral pulse methotrexate therapy. Ann Intern Med. 1987;106:231-5. LinkGoogle Scholar3. Mullarkey M. N Engl J Med. 1988;318:603-7. CrossrefMedlineGoogle Scholar4. Nordstrom D, West S, Anderson P, and Shrap J. Pulse methotrexate therapy in rheumatoid arthritis. Ann Intern Med. 1987;107:797-801. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Martin J. Weiner, MDAffiliations: Mount Sinai School of Medicine New York, NY 10029 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOther Interventions for Chronic UrticariaThe therapeutic role of methotrexate in chronic urticaria: A systematic reviewUse of nonbiologic treatments in antihistamine-refractory chronic urticaria: a review of published evidenceChronic spontaneous urticaria: latest developments in aetiology, diagnosis and therapyThe diagnosis and management of acute and chronic urticaria: 2014 updateThe Management and Treatment of Chronic UrticariaTherapeutic alternatives for chronic urticaria: an evidence-based review, part 2Idiopathic Recurrent AngioedemaUrticaria and angioedema: an overviewMethotrexate-responsive chronic idiopathic urticaria: a report of two cases.Allergists and dermatologists have far more expertise in caring for patients with urticaria than other specialistsMethotrexate-induced exacerbation of urticarial vasculitis: an unusual adverse reactionDrug Therapy of Chronic Urticaria and Angioedema 15 May 1989Volume 110, Issue 10Page: 848-848KeywordsAsthmaMethotrexatePrimary biliary cirrhosisPrimary sclerosing cholangitisPsoriasisRheumatoid arthritisUrticaria ePublished: 1 December 2008 Issue Published: 15 May 1989 PDF downloadLoading ...
AN APPARATUS FOR THE STUDY OF RESPIRATORY QUOTIENT AND BASAL METABOLISM OF MICE
Authors: Albert H. Ebeling, Robert B. Corey
Journal: The Journal of Experimental Medicine (1930)

A simple apparatus has been developed for the study of the respiratory quotient and basal metabolism of mice. Data are given which indicate that the values for the respiratory quotient obtained are accurate to within 0.02. The apparatus is especially designed for rapid, routine manipulation.
De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero
Authors: K HONG, D PIPER, A DIAZVALDECANTOS, J BRUGADA, A OLIVA, E BURASHNIKOV, J SANTOSDESOTO, J GRUESOMONTERO, E DIAZENFANTE, P BRUGADA
Journal: Cardiovascular Research (2005)

We describe a genetic basis for atrial fibrillation and short QT syndrome in utero. Heterologous expression of the mutant channel was used to define the physiological consequences of the mutation.A baby girl was born at 38 weeks after induction of delivery that was prompted by bradycardia and irregular rythm. ECG revealed atrial fibrillation with slow ventricular response and short QT interval. Genetic analysis identified a de novo missense mutation in the potassium channel KCNQ1 (V141M). To characterize the physiological consequences of the V141M mutation, Xenopus laevis oocytes were injected with cRNA encoding wild-type (wt) KCNQ1 or mutant V141M KCNQ1 subunits, with or without KCNE1.Ionic currents were recorded using standard two-microelectrode voltage clamp techniques. In the absence of KCNE1, wtKCNQ1 and V141M KCNQ1 currents had similar biophysical properties. Coexpression of wtKCNQ1+KCNE1 subunits induced the typical slowly activating and voltage-dependent delayed rectifier K(+) current, I(Ks). In contrast, oocytes injected with cRNA encoding V141M KCNQ1+KCNE1 subunits exhibited an instantaneous and voltage-independent K(+)-selective current. Coexpression of V141M and wtKCNQ1 with KCNE1 induced a current with intermediate biophysical properties. Computer modeling showed that the mutation would shorten action potential duration of human ventricular myocytes and abolish pacemaker activity of the sinoatrial node.The description of a novel, de novo gain of function mutation in KCNQ1, responsible for atrial fibrillation and short QT syndrome in utero indicates that some of these cases may have a genetic basis and confirms a previous hypothesis that gain of function mutations in KCNQ1 channels can shorten the duration of ventricular and atrial action potentials.