tbuckley/cabot-search huggingface dataset:
An Accurate Risk Score Based on Anthropometric, Dietary, and Lifestyle Factors to Predict the Development of Type 2 Diabetes
Authors: Peter E.H. Schwarz, Jiang Li, Heiko Wegner, Stefan R. Bornstein, Joana Lindström, Jaakko Tuomilehto
Journal: Diabetes Care (2007)

We read with interest the article by Schulze et al. (1) that describes the development of the accurate German Diabetes Risk Score (DRS) to predict the development of type 2 diabetes. There is a clear consensus that it is necessary to have simple noninvasive tools for screening diabetes risk in order to identify persons who are eligible for further diagnostic assessments or preventive interventions (2).

An alternative test is the Finnish DRS (3), which is based on a categorical model and currently used in population-based type 2 diabetes prevention projects in several countries. In practice, the Finnish DRS score can be …
Abstract LB-313: Soluble UL16 binding protein 2 is elevated in the sera of lung cancer patients
Authors: Kosuke Yamaguchi, Hiroki Chikumi, Naoki Kinoshita, Asuka Shimizu, Kiyoshi Hashimoto, Jun Kurai, Akira Yamasaki, Masaki Nakamoto, Shingo Matsumoto, Miyako Takata, Tadashi Igishi, Naoto Burioka, Eiji Shimizu
Journal: Cancer Research (2010)

Abstract NKG2D ligands are the surface molecules which induce expression on transformed cells. Specifically they bind to NKG2D on NK cells, and this binding induces activation of NK cells. In humans, NKG2D ligands are described as MICA, MICB and ULBP1, 2, 3, and 4. In this study, we explored the clinical and immunological significance of NKG2D ligands on lung cancer. We evaluated the expression of each NKG2D ligand on the cell surface of various lung cancer cell lines by flow cytometory. The soluble form of ULBP2 was measured in culture supernatant and in sera of lung cancer patients by an original developed ELISA system. Immunological effects of cell surface ULBP2 and soluble form of ULBP2 were examined by 3.5-h 51Cr release assay. We found that ULBP2 was the most widely and strongly expressed NKG2D ligand in lung cancer cell lines. Soluble form of ULBP2 was increased in culture supernatant of the lung cancer cell lines with high expression of cell surface ULBP2. In addition, soluble form of ULBP2 was detectable in the sera of lung cancer patients and increased amount of soluble ULBP2 in sera significantly correlated with poor prognosis lung cancer patients. We evaluated the the immunological effect of soluble ULBP2 separately using human peripheral blood mononuclear cells (PBMCs), and found that soluble ULBP2 suppressed NK activity. In conclusion, ULBP2 is the most significant NKG2D ligand in lung cancer and its soluble form was detectable and elevated in sera of lung cancer patients. Because soluble form of ULBP2 is one of the determinant factor of the anti-tumor immunity of the cancer patients, the development of intervention in this effect would be a candidate for the promising immuno-modulatory therapy Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-313.
BRISTOL ROYAL INFIRMARY: COMPOUND FRACTURE OF THE THIGH, AND PRIMARY AND SECONDARY AMPUTATION
Authors: A. Prichard
Journal: BMJ (1856)

THZ subject of compound fracture, and of primary and secondary amputation of the thigh, has been occasionally brought before the profession within the last few months, in the interesting records published by some of the able surgeons who have had opportunities of witnessing these accidents on a large scale in the late war.The want of success of primary amputation of the thigh, among both French and English, has been most discouraging.Writers on military surgery say most justly that the condition of the patient is generally unfavourable, and that the nature of the injury is so different from that which goes by the same name in civil surgery, that no comparison can be fairly made with reference to the results of treatment.It is ,obvious, without anyargument,that the shattering ofa thigh bone by a rifle-ball, which completely perforates the limb, must be a very different and more severe degree of injury than that produced by a fall, when the fractured extremity of the bone is thrust through the integuments.This
IMPACT OF P2Y12 INHIBITOR CHOICE ON 30-DAY OUTCOMES AFTER PRIMARY PCI: AN ANALYSIS FROM THE EUROMAX TRIAL
Authors: Kurt Huber, Christian W. Hamm, Arnoud van't Hof, Frederic Lapostolle, Pierre Coste, Michel Thicoipe, Giovanni Gordini, Jacob Steinmetz, Freek Verheugt, Jennifer Adgey, Lutz Nibbe, Vojko Kanic, Peter Clemmensen, Debra Bernstein, Jayne Prats, Efthymios N. Deliargyris
Journal: Journal of the American College of Cardiology (2014)
Unexpected diminished innervation of epidermis and dermoepidermal junction in lichen amyloidosus
Authors: B. Maddison, M.R. Namazi, L.S. Samuel, J. Sanchez, R. Pichardo, J. Stocks, D. Maruziva, G. Yosipovitch
Journal: British Journal of Dermatology (2008)

Lichen amyloidosus is a localized, chronic, pruritic skin disease characterized by deposition of amyloid in the papillary dermis. The pathogenesis of the pruritus of lichen amyloidosus is largely unknown.To determine any change in the nerve fibre density in lichen amyloidosus lesions as an explanation for itch.Using an antibody to protein gene product (PGP) 9.5, the immunohistochemical analysis of the skin biopsies of 30 Hispanic patients with clinicopathologically proven lichen amyloidosus and of 11 healthy Hispanic controls matched for age, sex and site was performed.Unexpectedly, the mean amount of PGP9.5 stain, a measure for nerve fibre amount, for the healthy controls was higher than the lichen amyloidosus group both in the epidermis (P < 0.0019) and dermoepidermal junction (P < 0.0064). No change was observed in the papillary dermis. Furthermore, the proportion of area covered by PGP9.5 showed a significant decrease in the epidermis (P < 0.0024) and dermoepidermal junction (P < 0.0075) in lichen amyloidosus compared with healthy controls. Age, gender and body site were found not to be influencing factors in nerve fibre amounts in lichen amyloidosus samples.We speculate that the severe pruritus observed in lichen amyloidosus might be the result of the hypersensitivity of the remaining nerve fibres as a response to an unexplained neurodegeneration of the absent nerve fibres.
Mammography and Palpable Breast Abnormalities
Authors: Arthur T. Evans
Journal: Annals of Internal Medicine (2004)

Letters4 May 2004Mammography and Palpable Breast AbnormalitiesArthur T. Evans, MD, MPHArthur T. Evans, MD, MPHFrom Cook County Hospital and Rush Medical College, Chicago, IL 60612.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-9-200405040-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their article on evaluation of abnormal mammography results and palpable breast abnormalities, Kerlikowske and colleagues (1) calculated likelihood ratios correctly but incorrectly defined the term in their footnotes to Tables 2, 3, and 5. They defined a likelihood ratio as “the ratio of diseased to nondiseased persons for a given test result.” A hypothetical example illustrates why this is incorrect. If among patients with a positive test result 90 had a given disease and 1 did not, and if among patients with a negative test result 10 had the disease and 9 did not, the ratio ...References1. Kerlikowske K, Smith-Bindman R, Ljung BM, Grady D. Evaluation of abnormal mammography results and palpable breast abnormalities. Ann Intern Med. 2003;139:274-84. [PMID: 12965983] LinkGoogle Scholar2. Sox HC, Blatt MA, Higgins MC, Marton KI. Medical Decision Making. Boston: Butterworth-Heinemann; 1988:75. Google Scholar3. Sackett DL, Haynes RB, Tugwell P. Clinical Epidemiology: A Basic Science for Clinical Medicine. Boston: Little, Brown; 1985:108. Google Scholar4. Black ER, Bordley DR, Tape TG, Panzer RJ. Diagnostic Strategies for Common Medical Problems. 2nd ed. Philadelphia: American Coll of Physicians; 1999:32. Google Scholar5. Black ER, Bordley DR, Tape TG, Panzer RJ. Diagnostic Strategies for Common Medical Problems. 2nd ed. Philadelphia: American Coll of Physicians; 1999:330. Google Scholar6. Michaels AD, Frances C. Saint-Frances Guide to Cardiology. Philadelphia: Lippincott Williams & Wilkins; 2001:23. Google Scholar Author, Article, and Disclosure InformationAuthors: Arthur T. Evans, MD, MPHAffiliations: From Cook County Hospital and Rush Medical College, Chicago, IL 60612. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEvaluation of Abnormal Mammography Results and Palpable Breast Abnormalities Karla Kerlikowske , Rebecca Smith-Bindman , Britt-Marie Ljung , and Deborah Grady Mammography and Palpable Breast Abnormalities Karla Kerlikowske Metrics 4 May 2004Volume 140, Issue 9Page: 764KeywordsClinical epidemiologyLikelihood ratioMammography ePublished: 4 May 2004 Issue Published: 4 May 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
NF- κ B Expression in Mononuclear Cells of Patients with Sepsis Resembles That Observed in Lipopolysaccharide Tolerance
Authors: MINOU ADIB-CONQUY, CHRISTOPHE ADRIE, PIERRE MOINE, KARIM ASEHNOUNE, CATHERINE FITTING, MICHAEL R. PINSKY, JEAN-FRANÇOIS DHAINAUT, JEAN-MARC CAVAILLON
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

The expression of NF- κ B was studied in freshly isolated peripheral blood mononuclear cells (PBMC) of patients with severe sepsis and major trauma. The expression of p65p50 heterodimer, the active form of NF- κ B, was significantly reduced for all patients as compared with control subjects. The p50p50 homodimer, an inhibitory form of NF- κ B, was reduced in the survivors of sepsis and in patients with trauma. Subsequent in vitro stimulation of PBMC with lipopolysaccharide (LPS) did not induce further NF- κ B nuclear translocation: the survivors of sepsis and trauma patients showed low expression of both p65p50 and p50p50, whereas nonsurvivors of sepsis showed a predominance of the inactive homodimer and a low p65p50/p50p50 ratio when compared with control subjects. In the later group of patients there was a reverse correlation between plasma IL-10 levels and the p65p50/p50p50 ratio after in vitro LPS stimulation (r = − 0.8, p = 0.04). The reduced expression of nuclear NF- κ B was not due to its inhibition by I κ B α , as very low expression of I κ B α , as well as low levels of p65 and p50 were found in the cytoplasm of PBMC from patients with sepsis and trauma when compared with control subjects. These results demonstrate that upon LPS activation, PBMC of patients with systemic inflammatory response syndrome show patterns of NF- κ B expression that resemble those reported during LPS tolerance: global down-regulation of NF- κ B in survivors of sepsis and trauma patients and the presence of large amounts of the inactive homodimer in the nonsurvivors of sepsis.
The Need to Improve
Authors: Richard W. Bergstrom
Journal: Diabetes Care (2003)

In this issue of Diabetes Care , Massing et al. (1) present the results of their review of Medicare claims from 13,660 diabetic patients who received regular outpatient care from a primary care physician ( n = 1,749). During a 24-month period, 31% received no lipid profile, 24% received only one lipid profile, and 45% of the diabetic patients received two or more lipid profiles. Further analysis revealed that Caucasians compared with African Americans were 1.6 times more likely to receive a lipid panel, and patients with stroke or heart failure were also less likely to receive a lipid profile.

There are clinical decisions pertaining to lipid screening made by the primary care physician that are not captured with Medicare claims data and may partially account for an under-representation of the adherence rates. One situation is a patient’s refusal to obtain a lipid profile. Another situation, which is rare, is the individual with a total cholesterol <100 mg/dl. In this case, the primary care physician may not request …
Integration of Psychosomatic Medicine in a Teaching Hospital
Authors: M. Jackson
Journal: Psychotherapy and Psychosomatics (1973)

The pioneer work of Dr. <i>M. Balint</i> in the use of psychotherapeutic techniques in medicine inspired the author to establish a discussion seminar with psychiatrists in training in a large teaching hospital. For several years, this group has been engaged in discussing the evaluation and treatment of psychosomatic referrals within the hospital, and this paper is a record of some of the experiences encountered. The work of <i>G. Engel</i> was found to be of great help in providing a conceptual framework for observations. Certain aims of the group were delineated at the outset and consideration is given to the extent to which these have been achieved. It was concluded that the amount of unrecognized psycho-pathology amongst general medical patients is very considerable, and that although serious psychopathology was commonly encountered in psychosomatic disorders, much could often be achieved with the expenditure of a relatively small amount of time. The use of longer-term methods of group psychotherapy is continuing.
The practicable paradox—the five minute emergency
Authors: Ayan S Panja
Journal: BMJ (2004)

At our surgery, each doctor offers four slots of five minutes each at the end of the morning for “genuine emergencies.” The other day I found myself whingeing to a colleague about the banal nature of complaints that patients often bring to these appointments. On one particular day the first patient wanted a sick note, the second had run out of paracetamol, another wanted to chase a physiotherapy referral that hadn't come through, and the last was a chap with an itchy bum. Each consultation ended with some gentle patient education. Admittedly, a small part of me was thankful that these weren't hugely taxing appointments, but I was mostly annoyed …
Cultural Competency Training and Performance Reports to Improve Diabetes Care for Black Patients
Authors: Thomas D. Sequist
Journal: Annals of Internal Medicine (2010)

Background: Increasing clinician awareness of racial disparities and improving communication may enhance diabetes care among black patients. Objective: To evaluate the effect of cultural competency training and performance feedback for primary care clinicians on diabetes care for black patients. Design: Cluster randomized, controlled trial conducted between June 2007 and May 2008. (ClinicalTrials.gov registration number: NCT00436176) Setting: 8 ambulatory health centers in eastern Massachusetts. Participants: 124 primary care clinicians caring for 2699 (36%) black and 4858 (64%) white diabetic patients. Intervention: Intervention clinicians received cultural competency training and monthly race-stratified performance reports that highlighted racial differences in control of hemoglobin A1c (HbA1c) and low-density lipoprotein (LDL) cholesterol levels and blood pressure. Measurements: Clinician awareness of racial differences in diabetes care and rates of achieving clinical control targets among black patients at 12 months. Results: White and black patients differed significantly in baseline rates of achieving an HbA1c level less than 7% (46% vs. 40%), an LDL cholesterol level less than 2.59 mmol/L (<100 mg/dL) (55% vs. 43%), and blood pressure less than 130/80 mm Hg (32% vs. 24%) (all P < 0.050). At study completion, intervention clinicians were significantly more likely than control clinicians to acknowledge the presence of racial disparities in the 8 health centers as a whole (82% vs. 59%; P = 0.003), within their local health center (70% vs. 51%; P = 0.020), and among their own patients (63% vs. 43%; P = 0.037). Black patients of clinicians in the intervention and control groups did not differ at 12 months in rates of controlling HbA1c level (48% vs. 45%; P = 0.24), LDL cholesterol level (48% vs. 49%; P = 0.40), or blood pressure (23% vs. 25%; P = 0.47). Limitation: 11% of primary care teams did not attend cultural competency training sessions. Conclusion: The combination of cultural competency training and race-stratified performance reports increased clinician awareness of racial disparities in diabetes care but did not improve clinical outcomes among black patients. Primary Funding Source: Robert Wood Johnson Foundation.
Abstract 16460: Mir-206, Distinct From MiR-1, Mediates YAP-Induced Cardiac Hypertrophy and Survival
Authors: Yanfei Yang, Junichi Sadoshima
Journal: Circulation (2011)

The Drosophila Hippo regulates apoptosis and proliferation through suppression of Yorkie, a transcription factor co-factor, and the microRNA, bantam. YAP, a homologue of Yorkie, stimulates hypertro...
Conflictual Maternal Attitudes towards Asthmatic Children
Authors: Alexander Meijer
Journal: Psychotherapy and Psychosomatics (1980)

Conflictual maternal attitudes with regard to eating problems, dependency and mood of asthmatic and matched non-asthmatic children of school age with similar personal and familial allergic predispositions were examined. The maternal attitudes, measured on the Mother-Child Questionnaire, were regarded as conflictual when significant low difference scores were found between eating well and eating badly; autonomy and dependency, and between cheerfulness and depression. Statistical testing on the difference scores of these categories in the two groups of children showed significant maternal conflicts in their evaluation of eating and depression of asthmatic boys. Implications of these findings were discussed.
Ursodeoxycholic Acid and Diets Higher in Fat Prevent Gallbladder Stones During Weight Loss: A Meta-analysis of Randomized Controlled Trials
Authors: Caroline S. Stokes, Lise Lotte Gluud, Markus Casper, Frank Lammert
Journal: Clinical Gastroenterology and Hepatology (2013)

The prevalence of gallstones is increasing in association with the obesity epidemic, but rapid weight loss also increases the risk of stone formation. We conducted a systematic review of the efficacy of strategies to prevent gallbladder stones in adults as they lose weight.Randomized controlled trials of nonsurgical strategies to prevent gallstones were identified by electronic and manual searches. Our final analysis included 13 trials, comprising 1836 participants undergoing weight loss through dieting (8 trials) or bariatric surgery (5 trials). The trials compared ursodeoxycholic acid (UDCA) or high-fat weight loss diets with control interventions. We performed random-effects meta-analyses and evaluated heterogeneity and bias with subgroup, sensitivity, regression, and sequential analysis.UDCA reduced the risk of ultrasound-verified gallstones compared with control interventions (risk ratio, 0.33; 95% confidence interval [CI], 0.18-0.60; number needed to treat, 9). This effect was significantly larger in trials of diets alone (risk ratio, 0.17; 95% CI, 0.11-0.25) than in trials of patients who underwent bariatric surgery (risk ratio, 0.42; 95% CI, 0.21-0.83) (test for subgroup differences, P =.03). UDCA reduced the risk of cholecystectomy for symptomatic stones (risk ratio, 0.20; 95% CI, 0.07-0.53). Diets high in fat content also reduced gallstones, compared with those with low fat content (risk ratio, 0.09; 95% CI, 0.01-0.61). The meta-analyses were confirmed in trials with a low risk of bias but not in sequential analysis. No additional beneficial or harmful outcomes were identified.On the basis of a meta-analysis of randomized controlled trials, during weight loss, UDCA and/or higher dietary fat content appear to prevent formation of gallstones.
Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas
Authors: A.K. Kivisaari, M. Kallajoki, T. Mirtti, J.A. McGrath, J.W. Bauer, F. Weber, R. Königová, D. Sawamura, K.C. Sato-Matsumura, H. Shimizu, M. Csikós, K. Sinemus, W. Beckert, V-M. Kähäri
Journal: British Journal of Dermatology (2008)

Background Patients with recessive dystrophic epidermolysis bullosa (RDEB) have an increased risk of developing rapidly progressive and metastatic cutaneous squamous cell carcinomas (SCC). It is unclear why these SCC behave more aggressively than sporadic SCC. Matrix metalloproteinases (MMP) are a family of endopeptidases that contribute to growth, invasion and metastasis of SCC. The role of MMP in RDEB‐associated SCC is not known. Objectives To investigate the expression of MMP‐7, MMP‐13 and MMP‐9 in RDEB‐associated SCC in comparison with sporadic SCC and Bowen's disease. Methods Immunohistochemical analysis of 25 RDEB‐associated SCC, 61 sporadic SCC and 28 sporadic lesions of Bowen's disease was carried out using monoclonal antibodies for MMP‐7, MMP‐9, MMP‐13 and E‐cadherin and syndecan‐1. Results MMP‐7 was detected in all RDEB‐associated SCC, in tumour cells within the invasive edge, where E‐cadherin and syndecan‐1 were markedly diminished or absent. MMP‐7 expression was also observed in 98% of sporadic SCC and in 68% of Bowen's diseases. MMP‐7 staining was significantly stronger in RDEB‐associated SCC than in sporadic SCC, and was most abundant in poorly differentiated tumours. MMP‐13 was detected in tumour cells in 96% of RDEB‐associated SCC and in all sporadic cutaneous SCC. MMP‐9 was detected in the inflammatory cells in all SCC examined. Conclusions These results identify MMP‐7 and MMP‐13 as tumour cell‐specific markers for SCC progression and as potential therapeutic targets in RDEB‐associated SCC. The pattern of immunolabelling suggests that MMP‐7 may shed E‐cadherin and syndecan‐1 from the SCC cell surface.
The Rational Diet for The Obese
Authors: I. Frank Tullis
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Dr. Retan's letter has called attention to the fact that present-day treatment of obesity of any degree is generally unsatisfactory. In my article, I simply elected to avoid a negative attitude. By no means is it<i>necessary</i>for every patient or even any patient to follow the suggestions I outlined. The ideal program is that which will be successful for that particular person, provided that the diet is nutritionally adequate and that there are no significant physiological abnormalities. As to commercial programs for weight control, I am sufficiently acquainted with only two to express an opinion. The Weight Watcher's Diet Program seems effective in some cases, but contrary to their views, I believe an active exercise program to be useful in obtaining valuable caloric balance. Also, it improves general health and vigor. The Counterweight Program sponsored by General Mills, Inc., provides both a nutritionally adequate diet and
Cutaneous metastases from a papillary thyroid carcinoma
Authors: A. Makris, J.R. Goepel
Journal: British Journal of Dermatology (1996)

Journal Article Cutaneous metastases from a papillary thyroid carcinoma Get access A. Makris, A. Makris Departments of Clinical Oncology Weston Park Hospital, Whitham Road, Sheffield S10 2SJ, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.R. Goepel J.R. Goepel Departments of Pathology, Weston Park Hospital, Whitham Road, Sheffield S10 2SJ, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 5, 1 November 1996, Pages 860–861, https://doi.org/10.1111/j.1365-2133.1996.tb03910.x Published: 01 November 1996