tbuckley/cabot-search huggingface dataset:
A piece of my mind. A woman's eyes
Authors: C. M. Voyles
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thiazide-induced photosensitivity: a study of 33 subjects
Authors: H. A. ADDO, J. FERGUSON, W. FRAIN-BELL
Journal: British Journal of Dermatology (1987)

The clinical features, action spectrum and subsequent course, are described in 33 subjects with thiazide-induced photosensitivity. The reaction appeared to be phototoxic in nature. The wavelengths involved were those of the longer UVA and, not infrequently, also the shorter UVB waveband. In most instances withdrawal of the drug resulted in clearance of the clinical reaction and a return of the action spectrum to normal. In the few subjects in whom the photosensitivity persisted, either in the form of the clinical reaction or an abnormal action spectrum, or both, either a specific photodermatosis was present or another potentially photoactive drug was being taken. In no instance, was there evidence of the induction of long-term chronic photosensitivity (persistent light reaction) following the withdrawal of the thiazide drug.
Abortion in the first trimester
Authors: M. Deeny
Journal: BMJ (1992)

tection should be available in time for the dipping season next year.General practitioners in rural areas can help by impressing on patients the importance of following the safety advice on the labels of all farm chemicals, including sheep dips, whether they contain organophosphates or not.Occasional reports are received of patients sus- pected to be suffering long term, recurrent effects from use of organophosphate sheep dips.Such effects do not equate with the known symptoms due to organophosphates used in sheep dips in Britain.The vague, flu-like symptoms of organophosphate poisoning resemble those of several zoonotic diseases (leptospirosis, brucellosis) en- countered in farm livestock.Awareness of the possibility of zoonotic disease is essential for a doctor faced with such symptoms in a patient who is associated with a farm.
NHS can perform well against the private sector without compromising its core values
Authors: A. Bartlett
Journal: BMJ (2015)

The analysis of NHS contracts awarded since April 2013 raises two questions.1 Firstly, how can the NHS succeed in commercial tenders? This is where it really loses out to the private sector. Secondly, how useful, in terms of the overall health economy, is commercial tendering?

I have been involved with commercial tenders in offender care. This has entailed NHS foundation trusts competing with other NHS providers, large private sector …
Hand Grenade Injuries Among Civilians
Authors: Robin M. Coupland
Journal: JAMA (1993)

To describe how noncombatants are injured by hand grenades in camps for displaced people, and to categorize grenade wounds according to the Red Cross wound classification.Case series.A surgical hospital in Khao I Dang refugee camp on the Thailand-Cambodia border.Seventy-four patients injured by hand grenades.Intravenous antibiotics and primary wound surgery.Combatant status of the patients, categorization of the wounds, surgical outcome, number of operations, and number of blood transfusions.Only 7% of the patients sustained their wounds in battle and 50% were women, children, or older men. Seventy had 91 wounds that could be categorized; 59% of the wounds were small, affecting only soft tissue. Few wounds were associated with fractures and none with comminuted fractures. Twenty-four soft-tissue wounds were treated conservatively with minimal morbidity and no mortality.Missiles (fragments or bullets) from hand grenades tend to produce wounds with little tissue damage. Serious injury is due to penetration of vital structures. The results permit a recommendation that certain small and uncomplicated fragment wounds can be treated initially without surgery.
Extragonadal Germ-Cell Tumors
Authors: NICHOLAS J. VOGELZANG
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 December 1982Extragonadal Germ-Cell TumorsNICHOLAS J. VOGELZANG, M.D.NICHOLAS J. VOGELZANG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-6-928 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Hainsworth and associates (1) was an outstanding example of continued progress in medical oncology. It appears that some extragonadal germ-cell tumors should be added to the list of malignancies "curable" with chemotherapy. I have several comments and questions about the article.First, the authors subdivided the tumors into broad histologic categories (that is, seminoma, embryonal carcinoma), yet they have not addressed the histologic heterogeneity that is inherent in germ-cell tumors. In a recent series of 12 patients with mediastinal non-seminomatous tumors, 5 had mixed histologic findings—embryonal carcinoma mixed with choriocarcinoma (2). Did the Hainsworth...References1. HAINSWORTHEINHORNWILLIAMSSTEWARTGRECO JLSMF. Advanced extragonadal germ cell tumors: successful treatment with combination chemotherapy. Ann Intern Med. 1982;97:7-11. LinkGoogle Scholar2. VOGELZANGRAGHAVANANDERSONROSAILEVITTKENNEDY NDRJSB. Mediastinal non-seminomatous germ cell tumors: the role of combined modality therapy. Ann Thorac Surg. 1982;33:333-9. CrossrefMedlineGoogle Scholar3. KUZURCOBLEIGHGRECOEINHORNOLDHAM MMFLR. Endodermal sinus tumor mediastinum. Cancer. 1982;50:766-74. CrossrefMedlineGoogle Scholar4. VOGELZANGBRONSONSAVINOFRALEY NDDE. An in vivo and in vitro model of human embryonal and yolk sac carcinoma. In: Cold Spring Harbor Conferences on Cell Proliferation: Teratocarcinoma Stem Cells. Vol. 10. Cold Spring Harbor, New York: Cold Spring Harbor Laboratories. (In press). Google Scholar1. KUZURCOBLEIGHGRECOEINHORNOLDHAM MMFLR. Endodermal sinus tumors of the mediastinum. Cancer. 1982;50:766-74. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Chicago Chicago, IL 60637 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1982Volume 97, Issue 6Page: 928-929KeywordsChemotherapy Issue Published: 1 December 1982 PDF DownloadLoading ...
Bilateral Aseptic Necrosis of Femur Following a 16-Day Course of Corticotropin
Authors: Armin E. Good
Journal: JAMA (1974)

CIRCUMSTANTIAL evidence relates systemic corticosteroid therapy to aseptic necrosis of bone. Daily doses as low as 5 mg of prednisone have been cited.<sup>1</sup>The shortest period of therapy incriminated to date is 30 days (methylprednisolone, 16 mg/day).<sup>2</sup>Corticotropin has been implicated following treatment courses as brief as 42 days (10 to 20 mg/day of corticotropin).<sup>3</sup>The average interval from onset of steroid therapy to appearance of hip pain is 33 months.<sup>2</sup> This report concerns aseptic necrosis of both femoral heads appearing in a young man nine months after a 16-day course of corticotropin therapy. His primary problem is multiple sclerosis, a disease not known to be associated with aseptic necrosis. <h3>Report of a Case</h3> A 23-year-old, moderately obese vocational student received a diagnosis of multiple sclerosis in 1970. One of his manifestations was right retrobulbar neuritis with visual acuity of 15/200. Beginning May 28, 1970, he
Heterotopic Gastric Mucosa in The Upper Esophagus: A Prospective Study of 33 Cases and Review of Literature
Authors: E. Jacobs, M. F. Dehou
Journal: Endoscopy (1997)

Background and Study Aims: The prevalence of endoscopically diagnosed heterotopic gastric mucosa in the upper esophagus (HGMUE) has been reported in a few studies, and varies from 0.1 to 10 %. Clinical relevance and possible association with other pathological conditions remain a matter of debate. A prospective study was carried out to determine the prevalence of HGMUE, the influence on it of age and sex, and to study the macroscopic and microscopic aspects of the lesion, its clinical relevance and possible association with other pathological conditions.
Rescue therapy with adefovir in decompensated liver cirrhosis patients with lamivudine-resistant hepatitis B virus
Authors: Hyun Young Woo, Jong Young Choi, Seung Kew Yoon, Dong Jin Suh, Seung Woon Paik, Kwang Hyub Han, Soon Ho Um, Byung Ik Kim, Heon Ju Lee, Mong Cho, Chun Kyon Lee, Dong Joon Kim, Jae Seok Hwang
Journal: Clinical and Molecular Hepatology (2014)

Background/Aims Adefovir dipivoxil (ADV) is a nucleotide analogue that is effective against lamivudine-resistant hepatitis B virus (HBV). The aim of this study was to determine the long-term clinical outcomes after ADV rescue therapy in decompensated patients infected with lamivudine-resistant HBV. Methods In total, 128 patients with a decompensated state and lamivudine-resistant HBV were treated with ADV at a dosage of 10 mg/day for a median of 33 months in this multicenter cohort study. Results Following ADV treatment, 86 (72.3%) of 119 patients experienced a decrease in Child-Pugh score of at least 2 points, and the overall end-stage liver disease score decreased from 16Â±5 to 14Â±10 (mean Â± SD, P<0.001) during the follow-up period. With ADV treatment, 67 patients (56.3%) had undetectable serum HBV DNA (detection limit, 0.5 pg/mL). Virologic breakthrough occurred in 38 patients (36.1%) and 9 patients had a suboptimal ADV response. The overall survival rate was 89.9% (107/119), and a suboptimal response to ADV treatment was associated with both no improvement in Child-Pugh score (â¥2 points; P=0.001) and high mortality following ADV rescue therapy (P=0.012). Conclusions Three years of ADV treatment was effective and safe in decompensated patients with lamivudine-resistant HBV. Keywords: Adefovir dipivoxil; Lamivudine-resistant; Decompensation; Hepatitis B virus
House Staff Education on a Private Medical Service
Authors: Philip A. Tumulty
Journal: JAMA (1963)

IT SEEMS evident that changes in medical economics have made the use of private patients mandatory for graduate medical education in both university and nonuniversity hospitals. The matter here discussed is the quality of education so derived. Can it be good?  The development and organization of such programs is an exceedingly heavy responsibility, for at stake are not only the careers of the young doctors participating in them, but the general quality of medical care in the community as well. Those in charge must be keenly sensitive to this responsibility, and to the important implications of what they are doing.  Lamentably, in some hospitals this responsibility is not always met, or even appreciated, and the emphasis is placed not on the quality of the educational experiences afforded, but rather on the urge to meet the practical needs of the attending staff or the hospital administration. Education becomes a garment to cover a series of practical needs which actually dominate the program, and eventually destroy it.
Eculizumab and Renal Transplantation in a Patient with CAPS
Authors: Bonnie E. Lonze, Andrew L. Singer, Robert A. Montgomery
Journal: New England Journal of Medicine (2010)

To the Editor: The catastrophic antiphospholipid antibody syndrome (CAPS) is an episodic, diffuse thrombotic microangiopathy observed in less than 1% of patients with antiphospholipid antibodies and is characterized by vascular occlusions involving three or more organ systems.1 Typically preceded by triggering events, such as infection, trauma, or surgery, CAPS culminates in multiorgan system failure and is fatal in half of those in whom it develops. Although renal failure is common in CAPS survivors, kidney transplantation has traditionally not been considered in these patients because of the lack of specific therapies for preventing recurrent CAPS and a surgical risk of death . . .
Developing human erythroid cells grown in transferrin‐free medium utilize iron originating from extracellular ferritin
Authors: J.M. Leimberg, A.M. Konijn, E. Fibach
Journal: American Journal of Hematology (2003)

In addition to transferrin, ferritin can also function as a source of iron for heme synthesis (Gelvin D, et al. Blood 1996;88:3200-3207; Meyron-Holtz EG, et al. Blood 1999;94:3205-3211). In the present study we investigate the effect of external ferritin on the proliferation and hemoglobinization of human erythroid precursors grown in transferrin-free cultures.
Points: Severe cutaneous reactions to captopril
Authors: F W Fairhead
Journal: BMJ (1985)

reiterated my comment' on the treatment of cysticercosis with metriphonate and by means of radioimmunotherapy.Some other advances should be mentioned.In addition to praziquantel2-4 the anthelmninthic flubendazole has recently been used in the management of neurocysticercosis, with apparent success.5 Injection of quinine sulphate in distilled water into subcutaneous cysticerci has also been reported to destroy the bladderworms, thus obviating the need for their surgical excision.6
The diarrhoea of famine and severe malnutrition--is glucagon the major culprit?
Authors: R J Levin
Journal: Gut (1992)

The diarrhoea of famine and severe malnutrition -is glucagon the major culprit?Intractable diarrhoea is usually the terminal condition of victims of famine and severe malnutrition.Despite many studies on the effects of starvation and malnutrition on the absorptive functions of the small intestine in animals,'"4 and a few in man,5'7 no satisfactory explanation exists for this diarrhoea.While it has often been attributed to bacterial infection, extensive bacteriological studies failed to confirm this and it is estimated that only approximately 15% of cases have a diarrhoea of infectious origin.8-"In the most detailed analysis of the effects of extreme malnutrition on Danish subjects (who had been incarcerated in a concentration camp), Helweg-Larsen, Hoffmeyer, Kieler et all identified three types ofdiarrhoea.The most prevalent was an endemic, progressive, afebrile 'hunger diarrhoea' while 'infectious diarrhoea' was infrequent.Sudden realimentation caused an 'alimentary diarrhoea'.All were potentially lethal in the severely weakened state of the subjects.According to Roediger,'2 the terminal diarrhoea of kwashiorkor and marasmus (corresponding to hunger diarrhoea) is the result of lack of luminal nutrition of enterocytes, and especially of colonocytes, which severely reduces their absorptive function.In his explanation, the diarrhoea is mainly caused by the loss of the reabsorptive (salvage?)capacity of the
Major histocompatibility complex class II genes and systemic sclerosis.
Authors: D Briggs, K I Welsh
Journal: Annals of the Rheumatic Diseases (1991)

1. In no ethnic group is the overall association between systemic sclerosis and the MHC strong enough for direct clinical use. MHC associations do support the classification of the disease into limited cutaneous systemic sclerosis and diffuse cutaneous systemic sclerosis. 2. Indications are that associations between specific subsets of patients with systemic sclerosis and genetic markers will assume greater importance both diagnostically and prognostically. The group with lung fibrosis look prime candidates, for example. 3. Genetic markers are useful means of relating chemically induced systemic sclerosis like disorders with the classical disease. Vinyl chloride disease provides an example. 4. Evidence is emerging of strong associations between certain genetic markers and autoantibody production; a similar story has emerged in systemic lupus erythematosus. We believe that, eventually, genetic tests will be used to influence treatment in at least a subset of patients with systemic sclerosis but that a dramatic breakthrough will not be made until we know how the genetics of the disease relate to the primary biochemical disease characteristic--that is, the overproduction of collagen. In this respect it has been suggested that the 59 flanking DNA of dermal collagen genes is particularly susceptible to the action of Scl-70 (topoisomerase I). A problem is how to tie this and the other observations discussed above together. The association of autoantibodies with topoisomerase I provides a tentative link between the MHC and collagen gene expression. Although the role and reason for anti-Scl-70 in systemic sclerosis is unknown, humoral autoimmunity, at least in systemic lupus erythematosus, seems to be strongly dependent on specific HLA genes.(ABSTRACT TRUNCATED AT 250 WORDS)
Elevated Admission Glucose and Mortality in Patients With Acute Pulmonary Embolism
Authors: Nathalie Scherz, José Labarère, Drahomir Aujesky, Marie Méan
Journal: Diabetes Care (2011)

Although associated with adverse outcomes in other cardiopulmonary conditions, the prognostic value of elevated glucose in patients with acute pulmonary embolism (PE) is unknown. We sought to examine the association between glucose levels and mortality and hospital readmission rates for patients with PE.We evaluated 13,621 patient discharges with a primary diagnosis of PE from 185 acute care hospitals in Pennsylvania (from January 2000 to November 2002). Admission glucose levels were analyzed as a categorical variable (≤110, >110-140, >140-170, >170-240, and >240 mg/dL). The outcomes were 30-day all-cause mortality and hospital readmission. We used random-intercept logistic regression to assess the independent association between admission glucose levels and mortality and hospital readmission, adjusting for patient (age, sex, race, insurance, comorbid conditions, severity of illness, laboratory parameters, and thrombolysis) and hospital (region, size, and teaching status) factors.Elevated glucose (>110 mg/dL) was present in 8,666 (63.6%) patients. Patients with a glucose level ≤110, >110-140, >140-170, >170-240, and >240 mg/dL had a 30-day mortality of 5.6, 8.4, 12.0, 15.6, and 18.3%, respectively (P < 0.001). Compared with patients with a glucose level ≤110 mg/dL, the adjusted odds of dying were greater for patients with a glucose level >110-140 (odds ratio 1.19 [95% CI 1.00-1.42]), >140-170 (1.44 [1.17-1.77]), >170-240 (1.54 [1.26-1.90]), and >240 mg/dL (1.60 [1.26-2.03]), with no difference in the odds of hospital readmission.In patients with acute PE, elevated admission glucose is common and independently associated with short-term mortality.
Points: Intensive antacid treatment for chronic peptic ulceration
Authors: C J de Gara
Journal: BMJ (1984)

November, p 1225) is apprehensive that the remarkably low figure of 4-1 perinatal deaths per 1000 (22 September, p 721) for planned home confinements will increase the demand for this service.There is no evidence as yet that planned home confinements are less safe than consultant booked deliveries.Although not conclusive, the published figures support a more liberal policy.1-4What is more important is that the number of unplanned, and often unattended, deliveries at home (perinatal mortality 67-5/1000 births) has remained constant over the years and may therefore have reached an irreducible minimum.In some areas of the country the domiciliary midwifery service has been dismantled.This must put this very high risk group at greater risk since there are no experienced midwives or doctors to attend these patients should they be called.' 1
Passive sensitization of human airways induces mast cell degranulation and release of tryptase
Authors: P. Berger, C. N′guyen, M. Buckley, E. Scotto‐Gomez, R. Marthan, J. M. Tunon‐de‐Lara
Journal: Allergy (2002)

Background: This study was designed to examine the effect of passive sensitization (PS) on human bronchial mast cells. PS with asthmatic serum induces a hyper‐responsiveness to nonspecific agonists, and immunoglobulin (Ig)E binding mainly on mast cells. Methods: Bronchi dissected out from 19 lung specimens were incubated in normal or asthmatic serum. Immunohistochemistry was performed using monoclonal antibodies (MoAbs) directed against tryptase, chymase, or c‐ kit . Mast cells were classified as fully granulated (type I), partly (type II) or largely degranulated (type III). Tryptase was measured in supernatant using ELISA. Contractile response was recorded in a separated set of experiments using an organ bath system. Results: PS decreased both tryptase positive cells (47.9 ± 10.0 vs. 26.7 ± 4.8 cell/mm 2 , P = 0.003) and chymase positive cells (26.1 ± 3.3 vs. 14.9 ± 1.8 cell/mm 2 , P = 0.01), but did not alter the number of c‐ kit positive cell. PS decreased the proportion of type I (55.4 vs. 28.9%, P &lt; 0.0001) and, concomitantly increased that of types II (23.2 vs. 41.0%, P &lt; 0.0001) and III (21.4 vs. 30.1%, P = 0.04). Following PS, tryptase concentration significantly increased and the magnitude of histamine response, was correlated with the amount of type II mast cells. Conclusion: PS of human isolated bronchi induces a mast cell degranulation related to in vitro hyper‐responsiveness, along with a tryptase release.
A Strong Genetic Association between the Tumor Necrosis Factor Locus and Proliferative Vitreoretinopathy: The Retina 4 Project
Authors: Jimena Rojas, Itziar Fernandez, Jose C. Pastor, Maria T. Garcia-Gutierrez, Maria R. Sanabria, Maria Brion, Rosa M. Coco, Jose M. Ruiz-Moreno, Jose Garcia-Arumi, Javier Elizalde, Miguel Ruiz-Miguel, Jose M. Gallardo, Rosa M. Corrales, Angel Carracedo
Journal: Ophthalmology (2010)
377 One year double-blind immunotherapy (IT) trial with mPEG-modified (mPEG) and the corresponding unmodified (der. p.) mite allergen preparations in adult mite asthmatics. II. In vitro results
Authors: S. Dreborg, A. Basomba, A. Almodovar, A. Campos, A.García Villalmanzo, A. Peleaz, I. Ljungstedt-Påhlman
Journal: Journal of Allergy and Clinical Immunology (1988)
"Crash Induction" For Tracheal Intubation
Authors: P. D. Woodbridge
Journal: JAMA (1967)

<h3>To the Editor:—</h3> In the ANESTHESIA PROBLEM (<b>201</b>:875, 1967) Bastron and Hamilton relate a case of "crash induction" for tracheal intubation followed immediately by crash deepening of anesthesia, and this in turn followed by cardiac arrest. Unfortunately they purposely avoid condemning this technique, although they do "point to the inherent narrow margin of safety which results with rapid inductions." I have used the endotracheal technique since 1927 (in the period when it was introduced into this country), fortunately without a known cardiac arrest, except toward the termination of operation. Because of this experience, I would use this significant case report to promote the following rule: After intubation, let automatic breathing establish itself before more than minimal concentrations of powerful narcotics or anesthetics are used. Immediately after intubation avoid what the authors so well describe as "pumping potent potions into paralyzed permissive patients." Furthermore, on theoretical grounds it appears dangerous