tbuckley/cabot-search huggingface dataset:
P08.10 * SINGLE BRAIN METASTASIS 9 YEARS AFTER ORTHOTOPIC LIVER TRANSPLANT WITH HISTOLOGICAL NEGATIVE EXPIANTED LIVER: CASE REPORT
Authors: R. Fornaro, A. Agnoletti, F. M. C. Specchia, D. Garbossa, M. Lanotte, A. Ducati
Journal: Neuro-Oncology (2014)

We describe the case of a 67 years old man, that underwent orthotopic liver transplant (OLT) in 2004 for cirrhosis. Native liver hystological examination was negative for focal hepatocarcinoma (HCC) areas. In 2008, during regular follow up, pulmonary lesions were found and diagnosed as hepatocarcinoma metastasis.In 2013, patient accused vertigo and dizziness: neuroimaging showed a cerebellar lesion. Hystological diagnosis was HCC metastases. The peculiarity is the onset of lung metastasis after transplant, with negative analysis on native liver, and brain metastasis after stable disease. This case is also relevant due to long survival related to the unavailability of many oncologic therapies in transplanted patients.
Assessment of Morphological Response Contributes to Selection of Candidates for Rescue Liver Resection Among Patients Undergoing Chemotherapy for Initially Unresectable Colorectal Liver Metastasis
Authors: Suzuki Koichi, Kato Takaharu, Muto Yuta, Ichida Kosuke, Fukui Taro, Takayama Yuji, Tsujinaka Shingo, Sasaki Junichi, Watanabe Fumiaki, Noda HIroshi, Horie Hisanaga, Rikiyama Toshiki
Journal: Annals of Oncology (2014)
A simplified method for the in vitro calibration of electromagnetic flowmeters
Authors: A. M. MARLON, M. H. ADAMS, B. L. BATES, C. L. PROFITT, D. C. HARRISON
Journal: Cardiovascular Research (1973)

A simple and reproducible gravity flow technique for the in vitro calibration of electromagnetic flow probes (EMFP) has been developed. The flow probe is mounted in a chamber instead of on an excised vessel and allows saline to flow directly past the contacts. Utilizing the calibrations determined by this technique, a comparison was made between cardiac outputs determined by indicator-dilution methods and the EMFP. There was good correlation (r=0·95) between flows determined by the two methods with low and normal outputs, but was less satisfactory (r=0·87) when high outputs were compared.
Vitamin E, but not pioglitazone, improved nonalcoholic steatohepatitis in nondiabetic patients
Authors: Sandeep Mukherjee
Journal: Annals of Internal Medicine (2010)

ACP Journal Club21 September 2010Vitamin E, but not pioglitazone, improved nonalcoholic steatohepatitis in nondiabetic patientsSandeep Mukherjee, MDSandeep Mukherjee, MDUniversity of Nebraska Medical Center, Omaha, Nebraska, USA (S.M.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-6-201009210-02012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362;1675-85. https://pubmed.ncbi.nlm.nih.gov/20427778Clinical Impact RatingsGIM/FP/GP: Hospitalists: Gastroenterology: References1 Angulo P. GI epidemiology: nonalcoholic fatty liver disease. Aliment Pharmacol Ther. 2007;25:883-9. [PMID: 17402991] Google Scholar2 Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology. 2009;49:306-17. [PMID: 19065650] Google Scholar3 Loomba R, Wesley R, Pucino F, et al. Placebo in nonalcoholic steatohepatitis: insight into natural history and implications for future clinical trials. Clin Gastroenterol Hepatol. 2008;6:1243-8. [PMID: 18829391] Google Scholar4 Briasoulis A, Tousoulis D, Antoniades C, Stefanadis C. The oxidative stress menace to coronary vasculature: any place for antioxidants? Curr Pharm Des. 2009;15:3078-90. [PMID: 19754382] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Nebraska Medical Center, Omaha, Nebraska, USA (S.M.)This article was published at Annals.org on 7 September 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 September 2010Volume 153, Issue 6Page: JC3-12KeywordsClinical trial reportingFatty liverFibrosisInflammationLiverMedical risk factorsNonalcoholic steatohepatitisPatientsSteatosisVitamin E ePublished: 21 September 2010 Issue Published: 21 September 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
New index ranks African countries on child welfare
Authors: P. Moszynski
Journal: BMJ (2008)

A league table of African governments’ child friendliness has been launched in Nairobi to mark the universal day of the child on 20 November.

The ranking has been compiled by the Addis Ababa based African Child Policy Forum to encourage African governments to be “more accountable to their future citizens.”

The survey, which ranks 52 African countries on more than 40 indicators, finds that some of the poorest nations are the most child friendly, because they have laws and policies in place to protect children’s rights. In addition, they have targeted their limited resources to provide basic needs for their …
Combination of patch test and IgE for dust mite antigens differentiates 130 patients with atopic dermatitis into four groups
Authors: Shuhei Imayama, Tamiko Hashizume, Hiroko Miyahara, Tomoko Tanahashi, Masaaki Takeishi, Yumiko Kubota, Tetsuya Koga, Yoshiaki Hori, Hidezo Fukuda
Journal: Journal of the American Academy of Dermatology (1992)
Cardiac and skeletal muscle abnormalities in cardiomyopathy: Comparison of patients with ventricular tachycardia or congestive heart failure
Authors: Ann Dunnigan, Nancy A. Staley, Stephen A. Smith, Mary Ella Pierpont, Dianne Judd, David G. Benditt, D. Woodrow Benson
Journal: Journal of the American College of Cardiology (1987)
A POLYMORPHISM IN THE PDE3A GENE PROMOTER THAT PREVENTS CAMP-INDUCED INCREASES IN TRANSCRIPTIONAL ACTIVITY, AND MAY PROTECT AGAINST PDE3A INHIBITOR DRUG TOLERANCE.
Authors: Michael R. Bristow, Matthew RG Taylor, Dobromir Slavov, Penny L. Blain-Nelson, Karin R. Nunley, Allen M. Medway, Carmen C. Sucharov
Journal: Journal of the American College of Cardiology (2010)
Cancer Converts Tobacco Lobbyist: Victor L. Crawford Goes On the Record
Authors: Andrew A. Skolnick
Journal: JAMA (1995)

SHAKESPEARE said it in<i>Julius Caesar</i>: "The evil that men do lives after them / The good is oft interred with their bones." Oft, but not always. Sometimes someone who does what many view as wrong has both the time and inclination to make amends. Victor Crawford does not have much time—he is dying of T2, N2c squamous cell stage IV carcinoma of the base of the tongue with pulmonary and bone metastases—but he does have the inclination to undo much of the harm he says he believes he caused as a lobbyist for the tobacco industry. Crawford, an attorney and retired Maryland state legislator who lives in Rockville, Md, worked as a contractual lobbyist for the Tobacco Institute during the late 1980s. He did it for the money, he says, although it wasn't very much. He estimates that he made at least $20 000 during the 6 years he helped
Royal Commission report
Authors: I. A G MacQueen
Journal: BMJ (1979)

Chemokines are likely to play an important role in regulating the trafficking of developing T cells within the thymus. By using anti-CD3ε treatment of recombinase-activating gene 2 (Rag2<sup>−/−</sup>) mice to mimic pre-TCR signaling and drive thymocyte development to the double positive stage, we have identified murine GPR-9-6 as a chemokine receptor whose expression is strongly induced following pre-TCR signaling. GPR-9-6 mRNA is present at high levels in the thymus, and by RT-PCR analysis its expression is induced as normal thymocytes undergo the double negative to double positive transition. Furthermore we show that TECK (thymus-expressed chemokine), a chemokine produced by thymic medullary dendritic cells, is a functional ligand for GPR-9-6. TECK specifically induces a calcium flux and chemotaxis of GPR-9-6-transfected cells. In addition, TECK stimulates the migration of normal double positive thymocytes, as well as Rag2<sup>−/−</sup> thymocytes following anti-CD3ε treatment. Hence, GPR-9-6 has been designated as CC chemokine receptor 9 (CCR9). Our results suggest that TECK delivers signals through CCR9 important for the navigation of developing thymocytes.
Baculovirus-transduced, VEGF-expressing adipose-derived stem cell sheet for the treatment of myocardium infarction
Authors: Tsung-Szu Yeh, Yu-Hua Dean Fang, Chia-Hsin Lu, Shao-Chieh Chiu, Chia-Lin Yeh, Tzu-Chen Yen, Yelena Parfyonova, Yu-Chen Hu
Journal: Biomaterials (2013)
Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia
Authors: Jitesh D. Kawedia, Chengcheng Liu, Deqing Pei, Cheng Cheng, Christian A. Fernandez, Scott C. Howard, Dario Campana, John C. Panetta, W. Paul Bowman, William E. Evans, Ching-Hon Pui, Mary V. Relling
Journal: Blood (2011)
Gene therapy of inherited skin adhesion disorders: a critical overview
Authors: M. De Luca, G. Pellegrini, F. Mavilio
Journal: British Journal of Dermatology (2009)

Gene therapy has the potential to treat devastating inherited diseases for which there is little hope of finding a conventional cure.These include lethal diseases, like immunodeficiencies or several metabolic disorders, or conditions associated with a relatively long life expectancy but poor quality of life and expensive and life-long symptomatic treatments, such as muscular dystrophy, cystic fibrosis and thalassaemia.Skin adhesion defects belong to both groups.For the nonlethal forms, gene therapy, or transplantation of cultured skin derived from genetically corrected epidermal stem cells, represents a very attractive therapeutic option, and potentially a definitive treatment.Recent advances in gene transfer and stem cell culture technology are making this option closer than ever.This paper critically reviews the progress and prospects of gene therapy for epidermolysis bullosa, and the technical and nontechnical factors currently limiting its development.
Hemoglobin Villejuif [β 123(H1) Thr→lle]: A new variant found in coincidence with polycythemia vera
Authors: H. Wajcman, A. Mrad, Y. Blouquit, C. Parmentier, J. Riou, F. Galacteros
Journal: American Journal of Hematology (1989)

A new abnormal hemoglobin, Hb Villejuif [beta 123(H1) Thr----Ile] has been discovered during the exploration of a polycythemia in a 87-year-old patient of French origin. The isoelectric focusing of the lysate revealed the presence of a variant hemoglobin with an isoelectric point very close to that of HbA. The oxygen binding properties of the patient's red blood cells being normal, it was clear that the polycythemia was not a consequence of the presence of this hemoglobin. In fact, the red blood cell morphology and the involvement of the other blood cell lines, demonstrating excessive hemopoiesis, led to the diagnosis of polycythemia vera.
Epidemiology of injuries among elite pre-professional ballet students
Authors: C Ekegren, R Quested, A Brodrick
Journal: British Journal of Sports Medicine (2011)

Background Dancers destined for a career in professional ballet undergo intensive training from a young age and have a reportedly high risk of injury. The extent of this risk is currently unclear as there is a deficiency of high-quality injury surveillance studies in dance. Objective To determine the incidence, nature and severity of injuries among a sample of elite pre-professional ballet students and to compare these factors across year level and gender. Design Prospective cohort study. Setting Three elite pre-professional ballet schools in London, UK. Participants 266 (107 male) full-time ballet students aged 15–19 years. Assessment of risk factors Year level and gender. Main outcome measurements Physiotherapists recorded injury details using a standardised database during the 2009–2010 academic year. Injury definition included ‘any dance injury resulting in medical attention and time lost from dance for &gt;1 day beyond the day of injury’. Incidence rate (IR) was reported per 1000 dance exposures (DE=1 performance, rehearsal or class). Injury severity was reported according to time loss and treatments required. Other details collected included type and anatomical location of injury and date and time of onset. Results 378 recordable injuries were sustained by 203 (76%) dancers over the study period. The IR was 1.9/1000 DEs. There were no significant differences in IRs between genders or between 1st and 2nd year students. However, 1st and 2nd year students had a significantly lower rate of injury than 3rd years (IR ratio 0.63, 95% CI 0.49 to 0.81 and IR ratio 0.75, 95% CI 0.59 to 0.95 respectively). Conclusion In comparison with other adolescent athletic populations, participants in this study had a similar injury incidence but a higher risk of injury. Third year students, who perform more than other students, had a higher injury rate than younger dancers. This may suggest that performances carry a higher risk of injury than classes.
Matched-Pair Analysis of Survival of Never Smokers and Ever Smokers With Squamous Cell Carcinoma of the Head and Neck
Authors: Kristen B. Pytynia, Jonathan R. Grant, Carol J. Etzel, Dianna B. Roberts, Qingyi Wei, Erich M. Sturgis
Journal: Journal of Clinical Oncology (2004)

To compare survival rates between patients with squamous cell carcinoma of the head and neck (SCCHN) without a history of smoking (never smokers) and those with a current or previous history of smoking (ever smokers).Fifty never smokers with newly diagnosed SCCHN were matched to 50 ever smokers according to sex, age, tumor site, overall stage, nodal stage, and treatment. Survival analysis was performed using Kaplan-Meier estimates. Matched-pair survival was compared using the Cox proportional hazards model.The never smokers had a greater overall survival (P =.020), disease-specific survival (P =.022), and recurrence-free survival (P =.016). Furthermore, matched-pair analysis demonstrated smoking was associated with a significant increase in risk of overall death (relative risk [RR] = 3.50; 95% CI, 1.14 to 10.77; P =.029), risk of death owing to disease (RR = 3.98; 95% CI, 1.11 to 14.33; P =.034), and risk of disease recurrence (RR = 3.29; 95% CI, 1.18 to 9.14; P =.023). Smoking was associated with three-fold increases in risk for overall death, death owing to disease, and recurrence after adjustment for cancer-associated symptom severity and alcohol use, but the 95% CI for these adjusted risk estimates each included the null.Survival differed significantly between never smokers and ever smokers with SCCHN. These results are not substantively explained by differences in cancer-associated symptoms or alcohol use, but the CIs are wide and some imprecision remains. Regardless, possible fundamental differences in SCCHN between ever smokers and never smokers may exist, and further molecular characterization of these tumors is needed to determine whether biologic differences needing targeted therapies exist.
Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias
Authors: Robert Clarke, Derrick A. Bennett, Sarah Parish, Petra Verhoef, Mariska Dötsch-Klerk, Mark Lathrop, Peng Xu, Børge G. Nordestgaard, Hilma Holm, Jemma C. Hopewell, Danish Saleheen, Toshihiro Tanaka, Sonia S. Anand, John C. Chambers, Marcus E. Kleber, Willem H. Ouwehand, Yoshiji Yamada, Clara Elbers, Bas Peters, Alexandre F. R. Stewart, Muredach M. Reilly, Barbara Thorand, Salim Yusuf, James C. Engert, Themistocles L. Assimes, Jaspal Kooner, John Danesh, Hugh Watkins, Nilesh J. Samani, Rory Collins, Richard Peto
Journal: PLoS Medicine (2012)

Robert Clarke and colleagues conduct a meta-analysis of unpublished datasets to examine the causal relationship between elevation of homocysteine levels in the blood and the risk of coronary heart disease. Their data suggest that an increase in homocysteine levels is not likely to result in an increase in risk of coronary heart disease.
Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis
Authors: Julia Hippisley-Cox, Carol Coupland
Journal: BMJ (2005)

To determine the comparative risk of myocardial infarction in patients taking cyclo-oxygenase-2 and other non-steroidal anti-inflammatory drugs (NSAIDs) in primary care between 2000 and 2004; to determine these risks in patients with and without pre-existing coronary heart disease and in those taking and not taking aspirin.
Modulation of the activity of calcium-activated neutral proteases (calpains) in chronic lymphocytic leukemia (B-CLL) cells
Authors: Jacek M. Witkowski, Emilia Zmuda-Trzebiatowska, Jakub M. Swiercz, Miroslawa Cichorek, Hanna Ciepluch, Krzysztof Lewandowski, Ewa Bryl, Andrzej Hellmann
Journal: Blood (2002)
BLOOD TESTS FOR PATERNITY
Authors: Alexander S. Wiener
Journal: JAMA (1930)

<h3>To the Editor:</h3> —The recent Chicago case in which the identification tags of two infants were mixed again makes one inquire what methods are available at present for determining paternity or nonpaternity. As for the determination of paternity, the courts still permit the use of the ancient and notoriously unreliable method of demonstrating similarity of the features of the putative father and the child. In only rare instances is this method justified, however, as when a white woman gives rise to a colored child and the putative father is colored, or when the child and putative father both have six fingers on each hand. The inheritance of certain physiologic traits may be made use of to prove nonpaternity in certain cases. In order to be applicable in medicolegal cases, such traits must fulfil three requirements: (1) they must be so sharply defined that all qualified observers will reach the same
Role of deregulation of the APC-WNT-beta catenin signaling and microsatellite instability in hepatic carcinogenesis. Preliminary results in a series of 20 sporadic hepatoblastomas and 11 non virus-related hepatocellular carcinomas
Authors: Michele Zuckermann, Massimo Pinzani, Maria Cristina Curia, C. Salini, G. Aceto, T. Catalano, P. Battista, G. Giuseppina, A. Cama, R. Mariani-Costantini, F. Cetta
Journal: Journal of Hepatology (2002)
AB0131 Lupus monocyte-derived dendritic cells treated with 1a,25-dihydroxyvitamin d3 and dexamethasone are tolerogenic and induce il-10 producing regulatory t cells
Authors: H. J. Wu, T. W. Luk, K. Y. Lam, C. S. Lau, A. Chan, M. Y. Mok
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The pathogenesis of systemic lupus erythematosus (SLE) is characterized by dysregulated dendritic cells (DCs) with over-production of type I interferon and hyperactive adaptive immune response. Clinical benefits of tolerogenic DCs have recently been shown in some murine models of immune mediated diseases. <h3>Objectives</h3> To examine if alternatively activated DCs (aaDCs) derived from SLE patients possess tolerogenic properties and to delineate the underlying mechanisms. <h3>Methods</h3> Lupus and healthy control aaDCs were generated by treating monocyte derived DCs using combination of 1α,25-Dihydroxyvitamin D3 (vitD3) and dexamethasone followed by maturation by lipopolysaccharide (LPS). These aaDCs were examined for phenotype and tolerogenic functions compared with LPS-matured DCs (matDCs). Activation markers and intracellular cytokine expression of T cells and/or DCs were measured by flow cytometry. ELISA was used to measure cytokine levels in supernatant. Western blot was performed for detection of RelB protein expression. <h3>Results</h3> Compared with matDCs, lupus aaDCs displayed semi-mature phenotype with low level of expression of co-stimulatory molecules and maturation markers (CD83, CD40), that remained stable despite challenge by CD40L, CpG-DNA and SLE serum. These aaDCs also possessed tolerogenic phenotype with suppressive effect on allogeneic T cell activation (CD25 and CD69 expression) and proliferation comparable to normal aaDCs. Lupus and normal aaDCs were shown to polarize normal and lupus naïve CD45RA+ T cells into T effector cells that were characterized by production of high level of IL-10, expression of Foxp3 mRNA and antigen-nonspecific suppressive effect on allogeneic third-party T cells. On the other hand, lupus and normal aaDCs skewed memory CD45RO+ T cells to less inflammatory phenotype with reduced expression of IFN-γ and IL-17. Although aaDCs displayed a cytokine profile of IL-12<sup>lo</sup>IL-10<sup>hi</sup>, addition of neutralizing anti-IL-12 and exogenous IL-10 to culture conditions did not reverse the suppressive effect of aaDCs on activation and proliferation of allogeneic T cells, suggesting their tolerogenicity cannot be accounted by cytokine imbalance between IL-12 and IL-10. On the other hand, aaDCs were found to express reduced level of RelB, a transcription factor regulating DC differentiation and maturation. <h3>Conclusions</h3> Lupus aaDCs demonstrated tolerogenic properties with induction of IL-10 producing T cells that have regulatory functions. Reduced expression of RelB in aaDCs may be the underlying mechanism for their tolerogenicity. <h3>Disclosure of Interest</h3> None Declared
In vivo human insulin release processes measured by intraportal sampling through transjugular intrahepatic portal-systemic shunt (TIPS)
Authors: T. Grøfte, N. Pørksen, J. Greisen, N.K. Aagaard, A. Mengel, J.D. Veldhuis, O. Schmitz, M. Rössle, H. Vilstrup
Journal: Journal of Hepatology (2000)
Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes.
Authors: M Kiniwa, M Gately, U Gubler, R Chizzonite, C Fargeas, G Delespesse
Journal: Journal of Clinical Investigation (1992)

Interleukin-12 is a recently discovered lymphokine displaying an array of in vitro activities suggesting a major role in protective immunity against infectious agents like viruses. This study provides evidence that IL-12 may also be implicated in the selection of the immunoglobulin isotypes. We show that picomolar concentrations of rIL-12 markedly inhibit the synthesis of IgE by IL-4-stimulated PBMC. The suppression of IgE is observed at the protein and at the mRNA levels, it is isotype specific, and it is abolished by neutralizing anti-IL-12 mAbs. IL-12 may suppress IgE synthesis by: (a) inducing the production of IFN-gamma, a known inhibitor of IgE synthesis and (b) by a novel mechanism which is IFN-gamma independent. The best evidence for this is from studies on IgE synthesis by IL-4-plus hydrocortisone-stimulated umbilical cord blood lymphocytes, which do not produce detectable amounts of IFN-gamma. In such cultures, rIL-12 inhibits IgE synthesis even in the presence of a large excess of neutralizing anti-IFN-gamma mAb.
Structure and Functions of the Medical Research Council
Authors: F. H. K. Green
Journal: BMJ (1948)

<h3>Summary</h3> Spike count correlations (SCCs) are ubiquitous in sensory cortices, are characterized by rich structure and arise from structured internal interactions. Yet, most theories of visual perception focus exclusively on the mean responses of individual neurons. Here, we argue that feedback interactions in primary visual cortex (V1) establish the context in which individual neurons process complex stimuli and that changes in visual context give rise to stimulus-dependent SCCs. Measuring V1 population responses to natural scenes in behaving macaques, we show that the fine structure of SCCs is stimulus-specific and variations in response correlations across-stimuli are independent of variations in response means. Moreover, we demonstrate that stimulus-specificity of SCCs in V1 can be directly manipulated by controlling the high-order structure of synthetic stimuli. We propose that stimulus-specificity of SCCs is a natural consequence of hierarchical inference where inferences on the presence of high-level image features modulate inferences on the presence of low-level features.