tbuckley/cabot-search huggingface dataset:
Community validation of the United Kingdom diagnostic criteria for atopic dermatitis in Romanian schoolchildren
Authors: None Popescu, None Popescu, None Williams, None Forsea
Journal: British Journal of Dermatology (1998)

Although the U.K. modification of Hanifin and Rajka's diagnostic criteria for atopic dermatitis (AD) for use in epidemiological studies has demonstrated good validity and repeatability when previously tested in a U.K. community setting, little is known about its performance in other countries where different cultural, educational and linguistic factors could impair validity. We used a questionnaire to test the validity of the U.K. criteria as a point prevalence measure of AD in 1114 Romanian schoolchildren aged 6–12 years against the clinical diagnosis of a dermatologist with an interest in AD, who was unaware of the questionnaire content and responses. The sensitivity and specificity of the U.K. criteria for AD in this setting was 74% and 99%, respectively, an improvement rather than a deterioration in validity when compared with the previous U.K. study. Test–retest repeatability for all of the questions pertaining to the U.K. criteria using the chance-corrected kappa statistic was high, with values of 0.72 and over. The positive predictive value of the criteria was lower than in the U.K. study (63% compared with 80%, respectively) due to the very low prevalence of AD in this study (2.4%). The validity of a parental report of ‘eczema’ was poor, with a sensitivity of 22%, specificity of 97% and positive predictive value of 18%. This study suggests that the U.K. criteria perform well in settings outside the U.K., although care has to be taken when using the criteria to ascertain cases in settings where the prevalence of AD is very low.
Cutaneous ectopic schistosomiasis.
Authors: D M MacDonald, J G Morrison
Journal: BMJ (1976)

Two cases of cutaneous schistosomiasis due to ectopic ova have recently been seen. Both patients presented with abdominal papular lesions, which were found on biopsy to contain schistosoma ova. To reach these abdominal sites mature worms probably migrate from the portal circulation to the paraumbilical veins, where they anastomose with veins of the caval system.
523 The combination of fura and CDDP increases the apoptosis of human HCC via FAS/FASL and its transduction
Authors: T KOGURE, Y UENO, N KANNO, K FUKUSHIMA, K NISHIOKA, E MIKAMI, T IWASAKI, T SHIMOSEGAWA
Journal: Hepatology (2003)

Oxidatively generated DNA damage is considered to be a significant contributing factor to cancer, aging, and age-related human diseases. It is important to detect oxidatively generated DNA damage to understand and clinically diagnosis diseases caused by oxidative damage. In this study, using selective enzymatic cleavage and quantum dot (QD) labeling, we developed a novel capillary electrophoresis-laser induced fluorescence method for the sensitive detection of oxidized DNA bases. First, oxidized DNA bases are recognized and removed by one DNA base excision repair glycosylase, leaving apurinic and apyrimidinic sites (AP sites) at the oxidized positions. The AP sites are further excised by the AP nicking activity of the chosen glycosylase, generating a nucleotide gap with 5′- and 3′- phosphate groups. After dephosphorylation with one alkaline phosphatase, a biotinylated ddNTP is introduced into the nucleotide space within the DNA strand by DNA polymerase I. The biotin-tagged DNA is further labeled with a QD-streptavidin conjugate via non-covalent interactions. The DNA-bound QD is well-separated from excess DNA-unbound QD by highly efficient capillary electrophoresis and is sensitively detected by online coupled laser-induced fluorescence analysis. Using this method, we can assess the trace levels of oxidized DNA bases induced by the Fenton reaction and UV irradiation. Interestingly, the use of the formamidopyrimidine glycosylase (FPG) protein and endonuclease VIII enables the detection of oxidized purine and pyrimidine bases, respectively. Using the synthesized standard DNA, the approach has low limits of detection of 1.1 × 10−19 mol in mass and 2.9 pM in concentration.
Predictive value of the serum bactericidal test for mortality in patients infected with multidrug-resistant Acinetobacter baumannii
Authors: Chun-Hsing Liao, Wang-Huei Sheng, Yee-Chun Chen, Chien-Ching Hung, Jann-Tay Wang, Shan-Chwen Chang
Journal: Journal of Infection (2007)
?-Arginine inhibits smooth muscle cell proliferation of vein graft intimal thickness in hypercholesterolemic rabbits
Authors: J Okazaki
Journal: Cardiovascular Research (1997)

Objective: The effect of the chronic administration of l-arginine on intimal thickness and the kinetics of smooth muscle cell proliferation in autovein grafts in hypercholesterolemic rabbits were examined. Methods: Male rabbits were fed a 1% cholesterol diet (control group) and a 1% cholesterol diet supplemented by 2.25% l-arginine HCl in drinking water (arginine group). Each group underwent reversed autologous vein bypass grafting of the left common carotid artery using the left external jugular vein. At 2 or 4 weeks after operation, intimal cell proliferation was determined by 5-bromo-2′-deoxyuridine (BrdU) incorporation and intimal thickness of the graft was measured with an ocular cytometer. At 4 weeks after operation, endothelium-dependent responses were examined by isometric tension recording. Results: At 4 weeks after operation, the level of plasma arginine and citrulline are significantly higher in the arginine group (n = 7), compared with the control (n = 7). Intimal thickness in the arginine group (n = 7) was significantly reduced, compared with that of the control (n = 7). At 2 weeks after operation, the BrdU labeling index of the control (n = 5) was significantly higher than that of the arginine group (n = 5). At 4 weeks after operation, ACh caused endothelium-dependent relaxation in the arginine group (n = 4), while in the control (n = 4), ACh did not relax. Conclusions: These results suggest that smooth muscle cell proliferation of the rabbit jugular vein grafts during hypercholesterolemia occurs at an early stage after graft implantation, prior to the development of intimal thickness. Intimal thickness of vein graft during hypercholesterolemia was reduced by chronic administration of dietary l-arginine, by inhibiting smooth muscle cell proliferation. The enhancement of NO production in the blood vessel wall may therefore be useful for preventing late graft failure.
Coronary Heart Disease in Patients with Diabetes
Authors: Steven M. Haffner
Journal: New England Journal of Medicine (2000)

Type 2 diabetes increases the risk of coronary heart disease by a factor of two to four.1 The relative increase in the rate of coronary heart disease among patients with diabetes in most studies is greater for women than for men. In the Framingham Heart Study1 (but not in all studies), the absolute incidence of coronary heart disease is similar among both men and women with diabetes, leading to the frequently made assertion that diabetes may eliminate women's protection against coronary heart disease. The increase in the incidence of coronary events is greater for more severe clinical outcomes, such as . . .
Abstract 5000: Upregulation of WDR26 promotes breast cancer cell growth, migration and invasion via enhancing PI3K/AKT signaling
Authors: Yuanchao Ye, Songhai Chen
Journal: Cancer Research (2014)

Abstract Background: The phosphatidylinositol 3-kinase (PI3K) pathway is one of the most deregulated pathways in breast cancer. One of PI3K isoforms, p110 β, has been shown to be activated predominantly by G protein-coupled receptors (GPCRs) through the heterotrimeric G protein βγ subunits (Gβγ), and plays a key role in breast cancer development. PI3Ks mediates their effects primarily through the activation of select AKT, which consists of three isoforms. We have recently made important observations that diverse GPCRs converge at Gβγ to promote breast tumor cell growth and migration both in vitro and in vivo, and that a novel Gβγ-interacting protein, WDR26, promotes Gβγ-dependent signal transductions, including PI3K/AKT activation. In this study, we have evaluated the role of WDR26 in regulating PI3K/AKT signaling for breast tumor cell growth, migration and invasion. Methods: The level of WDR26 expression was evaluated in breast cancer cells and human breast cancer samples by Western blotting and immunohistochemistry analysis. WDR26 was then downregulated by siRNAs or overexpressed in breast cancer cells, and the effects on PI3K/AKT activation, tumor cell proliferation, migration and invasion were evaluated in vitro. Results: WDR26 was upregulated in a subset of highly malignant and invasive breast tumor cell lines (such as MDA-MB231 and DU4475), and high grade human breast tumor samples. Upon GPCR stimulation of breast tumor cells, WDR26 facilitated the formation of a signaling complex consisting of Gβγ, PI3Kβ and AKT2. Downregulation of WDR26 in MDA-MB231 and DU4475 cells using RNA interference inhibited PI3K/AKT activation, tumor cell growth, migration and invasion. Similar effects were achieved by disruption of WDR26 function through induced expression of WDR26 deletion mutants in MDA-MB231 cells. Conversely, overexpression of WDR26 in MCF7 cells enhanced PI3K/AKT activation and rendered MCF7 cell migration and enhanced proliferation. Conclusions: Together, these results indicate that WDR26 serves as a scaffold to foster interactions between Gβγ, PI3Kβ and AKT2, thereby promoting Gβγ-dependent PI3K/AKT activation, thereby regulating breast tumor progression. WDR26, thus, may represent a novel target for the intervention of breast tumors. Note: This abstract was not presented at the meeting. Citation Format: Yuanchao Ye, Songhai Chen. Upregulation of WDR26 promotes breast cancer cell growth, migration and invasion via enhancing PI3K/AKT signaling. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5000. doi:10.1158/1538-7445.AM2014-5000
A piece of my mind. No shattered vision
Authors: N. S. Calman
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pemphigus vulgaris and thymoma. A T-lymphocyte defect'
Authors: GUNNAR KAVLI
Journal: British Journal of Dermatology (1978)

Journal Article Pemphigus vulgaris and thymoma. A T‐lymphocyte defect' Get access GUNNAR KAVLI GUNNAR KAVLI Department of Dermatology, University of Tromsø, 9012 Tromsø, Norway Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue 1, 1 July 1978, Pages 97–98, https://doi.org/10.1111/j.1365-2133.1978.tb01966.x Published: 01 July 1978
Subgroup analyses: how to avoid being misled
Authors: John Fletcher
Journal: BMJ (2007)

<h3>Background</h3> Primary care settings have implemented processes to resolve population-level care gaps, including patient reminders, health record prompts, and outreach to patients/families. When patients present outside of primary care but still within the larger health system, these primary-care based processes are not applied, and opportunities to resolve care gaps are missed. We hypothesized that we could resolve care gaps outside the primary care setting by creating an 'inreach' process within the larger healthcare system. <h3>Objectives</h3> Among children 2–66 months of age within our primary care registry, we aimed to identify and resolve care gaps for children admitted to the hospital medicine service, Our goal was to contact the inpatient team for at least 80% of these patients, and to increase the percent of care gaps closed from 30% to 50%. <h3>Methods</h3> A multidisciplinary team of physicians, nurses and improvement experts mapped the baseline process. Failure modes were predicted, and a key driver diagram was developed. Through multiple PDSA cycles, we designed and tested a prototype inreach process. We then operationalized this process for patients admitted to the hospital medicine service, and focused on weekly failures to achieve process reliability. <h3>Results</h3> Assessments of care gaps increased from 0% to 88% by the end of December 2018. The percentage of care gap resolution has increased from 30% to 40%. <h3>Conclusions</h3> Using QI methods, a new process to help improve population health for children can be successfully implemented outside of the traditional domain of primary care.
"No, I Don't Know" Therapy
Authors: Joan R. Dembinski
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Briggs (<b>217</b>:1705, 1971) commented on the "You know syndrome." The dangers inherent in this syndrome are insidious; communication seems to reach a standstill, although your attention is compelled by the constant referral to "you" and the hidden compliment that you are aware. I have been left bewildered after talking with people of different ages. While hearing and agreeing, I admittedly did not understand completely! To interject "No, I really don't know or understand" may have broken a train of thought. But now I find it to be an almost necessary inquiry when an exchange of ideas is involved. The frequency of this subtle "you know" habit or pitfall may be increasingly noted in conversations and general television viewing. A syndrome, easily cured by a healthy "I don't know, please explain," would bring about a greater understanding of ideas for all ages.
Review: Gabapentin reduces some types of chronic neuropathic pain more than placebo in adults
Authors: Roger Chou
Journal: Annals of Internal Medicine (2011)

ACP Journal Club19 July 2011Review: Gabapentin reduces some types of chronic neuropathic pain more than placebo in adultsRoger Chou, MDRoger Chou, MDOregon Health & Science University, Portland, Oregon, USA (R.C.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-2-201107190-02008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationMoore RA, Wiffen PJ, Derry S, McQuay HJ. Gabapentin for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2011(3):CD007938. https://pubmed.ncbi.nlm.nih.gov/21412914Clinical Impact RatingsGIM/FP/GP: Endocrinology: Neurology: References1 Steinman MA, Bero LA, Chren MM, Landefeld CS. Narrative review: the promotion of gabapentin: an analysis of internal industry documents. Ann Intern Med. 2006;145:284-93. [PMID: 16908919] Google Scholar2 Chou R, Carson S, Chan BK. Gabapentin versus tricyclic antidepressants for diabetic neuropathy and post-herpetic neuralgia: discrepancies between direct and indirect meta-analyses of randomized controlled trials. J Gen Intern Med. 2009;24:178-88. [PMID: 19089502] Google Scholar Author, Article, and Disclosure InformationAffiliations: Oregon Health & Science University, Portland, Oregon, USA (R.C.)This article was published at Annals.org on 5 July 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComparison of Analgesic Effect between Gabapentin and Diclofenac on Post-Operative Pain in Patients Undergoing Tonsillectomy 19 July 2011Volume 155, Issue 2Page: JC1-8KeywordsClinical trial reportingClinical trialsDatabasesDrugsFibromyalgiaNeuropathic painNeuropathyPainSystematic reviews ePublished: 19 July 2011 Issue Published: 19 July 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Selective accumulation of the first component of complement and leukocytes in ischemic canine heart muscle. A possible initiator of an extra myocardial mechanism of ischemic injury.
Authors: R D Rossen, J L Swain, L H Michael, S Weakley, E Giannini, M L Entman
Journal: Circulation Research (1985)

Myocardial concentrations of C1q, a subunit of the first component of complement, were measured 5-120 minutes after ligation of a coronary artery in dogs injected with 125I-labeled human C1q and 131I-labeled human albumin. The 131I-labeled human serum albumin was used as a plasma protein marker. Ischemic regions of myocardium were defined by measuring regional myocardial blood flow by the reference sample method at intervals after coronary artery occlusion. Significant accumulations of 125I-C1q were demonstrated in the ischemic myocardium after coronary artery occlusions lasting 45 minutes. Some localization of C1q in ischemic myocardium was observed after a 15-minute occlusion, but the accumulations of C1q achieved in this case were not statistically significant. After coronary artery occlusions lasting greater than or equal to 45 minutes, left ventricular concentrations of C1q correlated reciprocally with regional myocardial blood flow. Moreover, high concentrations of C1q persisted in formerly ischemic segments after reperfusion. Radiolabeled neutrophils also accumulated selectively in ischemic segments relatively rich in C1q. It is suggested that complement activation may initiate the neutrophil-dependent portion of ischemic injury, delineated in recent years, that is associated with free radical release by phagocytic cells.
Reversible Acute Leukopenia and Cefoxitin
Authors: MARTIN SHANSKY
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 June 1980Reversible Acute Leukopenia and CefoxitinMARTIN SHANSKY, M.D., CAL W. GREENLAW, PHARM.D.MARTIN SHANSKY, M.D.Search for more papers by this author, CAL W. GREENLAW, PHARM.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-6-874_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Numerous case reports have implicated penicillin, its derivatives, and cephalosporins in causing infrequent neutropenia (1-3). DiCato and Ellman (4) reported four cases of granulocytopenia secondary to cephalothin in their institution during a 1-year period and suggested an incidence of 0.1%. Homayouni and colleagues (1) reported leukopenia in two patients receiving cephalothin and two receiving cefamandole. In a study of cefoxitin efficacy for pelvic infections, White and coworkers (5) briefly mention a patient who developed transient neutropenia secondary to cefoxitin therapy. This case appears to be the only one the medical literature of neutropenia as a complication of...References1. HOMAYOUNIGROSSSETIALYNCH HPUT. Leukopenia due to penicillin and cephalosporin homologues. Arch Intern Med. 1979;139:827-8. CrossrefMedlineGoogle Scholar2. DAVISSELIGMANHEWITTFINEGOLD AJWS. Neutropenic reaction to cephalothin therapy. Antimicrob Agents Chemother. 1963:272-7. MedlineGoogle Scholar3. GRAFTARLOV MA. Agranulocytosis with monohistiocytosis associated with ampicillin therapy. Ann Intern Med. 1968;69:91-5. LinkGoogle Scholar4. DICATOELLMAN ML. Cephalothin-induced granulocytopenia. Ann Intern Med. 1975;83:671-2. LinkGoogle Scholar5. WHITEGEELEDGER JCW. The use of intravenous cefoxitin sodium in patients with obstetric/gynecologic infections. J Antimicrob Chemother. 1978;4:239-40. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARTIN SHANSKY, M.D.; CAL W. GREENLAW, PHARM.D.Affiliations: Holy Cross Hospital Ft. Lauderdale, FL 33308 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCephalosporin-induced immune cytopenia in the dog: Demonstration of erythrocyte-, neutrophil-, and platelet-associated igg following treatment with cefazedoneCephalosporin-induced Changes in the Ultrastructure of Canine Bone MarrowAdverse Reactions and Interactions with Newer Cephalosporin and Cephamycin AntibioticsCefamandole and CefoxitinCHARLES V. SANDERS, M.D., RICHARD N. GREENBERG, M.D., ROBERT L. MARIER, M.D.Cefmenoxime: Clinical EvaluationNeutropenia Associated with Cefotaxime 1 June 1980Volume 92, Issue 6Page: 874-875KeywordsNeutropeniaPenicillin ePublished: 1 December 2008 Issue Published: 1 June 1980 PDF downloadLoading ...
REPORT ON TWO OF THE CHILDREN OPERATED ON BY LORENZ.
Authors: HARRY M. SHERMAN
Journal: JAMA (1904)

In May, 1903, I removed the dressings from two of the children who had been operated on for congenital dislocation of the hip by Professor Lorenz of Vienna, when he was in San Francisco in November, 1902. One of these cases I had seen in November, 1900, but the parents then declined treatment, coming back to San Francisco two years later, however, when they heard of Lorenz. This case returned to me by agreement when the time came for the removal of Lorenz's dressings. The other case was the child of a physician, and had never been seen by me until he was on the operating table, but returned to me, also by agreement, as did the first. In each instance there were several surgeons present when the splints were removed. The children were radiographed immediately after the splints were off, before any examination was permitted, and this record being
THE X-RAY DIAGNOSIS OF GAS IN THE TISSUES
Authors: J. D. Morgan, G. Vilvandre
Journal: BMJ (1917)

TISSUES.[JAN 6, I)I7 peripberal blood should prove a preventive of relapses, blackwater fever itself may possibly be greatly diminished by the tartar emetic treatment.CASE Iv.-Benign Tertian Ga)mietes disappearing from the Blood after the iltraveniouis Iiijection of T'artar Emetic.
Year in review in intensive care medicine, 2004. III. Outcome, ICU organisation, scoring, quality of life, ethics, psychological problems and communication in the ICU, immunity and hemodynamics during sepsis, pediatric and neonatal critical care, experimental studies
Authors: Peter Andrews, Elie Azoulay, Massimo Antonelli, Laurent Brochard, Christian Brun-Buisson, Geoffrey Dobb, Jean-Yves Fagon, Herwig Gerlach, Johan Groeneveld, Jordi Mancebo, Philipp Metnitz, Stefano Nava, Jerome Pugin, Michael Pinsky, Peter Radermacher, Christian Richard, Robert Tasker, Benoit Vallet
Journal: Intensive Care Medicine (2005)