Changes in Renal Function
Authors: WILLIAM T. BUTLER
Journal: Annals of Internal Medicine (1964)

Clinical Staff Conference1 August 1964Changes in Renal FunctionWILLIAM T. BUTLER, M.D.WILLIAM T. BUTLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-2-344 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptReported abnormalities of renal function after treatment with amphotericin B are listed on Table 1. During treatment with the colloidal form of amphotericin B (Fungizone® for Infusion), the form available for clinical use, over five sixths of patients have developed abnormal blood urea nitrogen or serum creatinine levels (1). In this regard it is noteworthy that in most instances the daily dosage of drug has been dependent more on the levelof azotemia present than upon the therapeutic response of the patient. In most early reports, however, authors have felt that these renal abnormalities were reversible after discontinuation of the...References1. BUTLERBENNETTALLINGWERTLAKEUTZHILL WTJEDWPTJPGJ: Nephrotoxicity of amphotericin B: early and late effects in 81 patients. Ann. Intern. Med. 61: 344, 1964. Google Scholar2. RUBINFURCOLOW HML: Promising results in cryptococcal meningitis. Neurology 8: 590, 1958. CrossrefMedlineGoogle Scholar3. BEARDRICHERTTAYLOR HWJHRR: The treatment of deep mycotic infections with amphotericin B. Amer. Rev. Resp. Dis. 81: 43, 1960. CrossrefMedlineGoogle Scholar4. BELLANDRIOLESABESINUTZ NHVTSMJP: On the nephrotoxicity of amphotericin B in man. Amer. J. Med. 33: 64, 1962. CrossrefMedlineGoogle Scholar5. RHOADESGINNMUCHMORESMITHHAMMARSTEN ERHEHGWOJF: The effect of amphotericin B upon renal function in man, in Antimicrobial Agents Annals 1960, Plenum Press, New York, 1961, p. 539. Google Scholar6. SANFORDRASCHSTONEHILL WGJRRB: The treatment of disseminated coccidioidomycosis with amphotericin B. Ann. Intern. Med. 56: 553, 1962. LinkGoogle Scholar7. WINN WA: Coccidioidomycosis and amphotericin B. Med. Clin. N. Amer. 47: 1131, 1963. CrossrefMedlineGoogle Scholar8. TAKACSTOMKIEWICZMERRILL FJZTJP: Amphotericin B nephrotoxicity and irreversible renal failure. Ann. Intern. Med. 59: 716, 1963. LinkGoogle Scholar9. YATESATAYLANGELUTTIGBHASHERFURCOLOW JLMNHVCAML: Experience with amphotericin in the therapy of histoplasmosis. Dis. Chest 37: 144, 1960. CrossrefMedlineGoogle Scholar10. BUTLERHILLSZWEDKNIGHT WTGJCFV: Amphotericin B renal toxicity in the dog. J. Pharmacol. Exp. Ther. 143: 47, 1964. MedlineGoogle Scholar11. WERTLAKEBUTLERHILLUTZ PTWTGJJP: Nephrotoxic tubular damage and calcium deposition following amphotericin B therapy. Amer. J. Path. 43: 449, 1963. MedlineGoogle Scholar12. BUTLERHILL WTGJ: Intravenous administration of amphotericin B in the dog. J. Amer. Vet. Med. Ass. 144: 399, 1964. MedlineGoogle Scholar13. MILLERMCDONALDSHOCK JHRKNW: The effect of bacitracin on renal function. J. Clin. Invest. 29: 389, 1950. CrossrefMedlineGoogle Scholar14. WINFIELDCRISPMAXWELLKLEEMAN MGOMHCR: Nephrotoxic effects of kanamycin: a preliminary report. Ann. NY Acad. Sci. 76: 140, 1958. CrossrefMedlineGoogle Scholar15. MOYERMILLSYOW JHLCEM: Toxicity of polymyxin B. I. Animal studies with particular reference to evaluation of renal function. Arch. Intern. Med. (Chicago) 92: 238, 1953. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe effect of thromboxane A2 receptor antagonism on amphotericin B-induced renal vasoconstriction in the ratBlastomycosis in AnimalsAcute Renal Failure Following Bone Marrow Transplantation: A Retrospective Study of 272 PatientsEffect of mannitol on acute amphotericin B nephrotoxicity3 Biological Activity of Polyene AntibioticsSpontaneous Resolution of Endogenous Candida Endophthalmitis Complicating Intravenous HyperalimentationChemistry and biology of the polyene macrolide antibioticsNephrotoxicity of amphotericin B, with emphasis on changes in tubular functionAntimicrobial therapy in systemic fungal infectionsChanges in Renal MorphologyGEORGE J. HILL II, M.D. 1 August 1964Volume 61, Issue 2Page: 344-349KeywordsAmphotericinBlood plasmaBlood urea nitrogenCreatinineDrugsVasoconstriction Issue Published: 1 August 1964 PDF downloadLoading ...