tbuckley/cabot-search huggingface dataset:
Eosinophils and atopic dermatitis
Authors: D. Simon, L. R. Braathen, H.‐U. Simon
Journal: Allergy (2004)

In spite of the progress regarding the description of immunological phenomena associated with atopic dermatitis (AD), the pathogenesis of this disease still remains unclear. The presence of eosinophils in the inflammatory infiltrate of AD has long been established. Eosinophil numbers as well as eosinophil granule protein levels in peripheral blood are elevated in most AD patients and appear to correlate with disease activity. Moreover, eosinophil granule proteins, which possess cytotoxic activity, are deposited in the skin lesions. These observations indicate a role of eosinophils in the pathogenesis of AD. Furthermore, AD is associated with increased production of T helper 2 cytokines including interleukin (IL)‐5, which specifically acts on eosinophils, resulting in accelerated eosinophilopoiesis, chemotaxis, cell activation, and delayed apoptosis. Therefore, IL‐5 is an interesting target for experimental therapy in this inflammatory disorder of the skin. Such studies might result in new insights into the pathogenetic role of eosinophils in AD.
Adult hepatic fibropolycystic disease presenting as obstructive jaundice.
Authors: A J Williams, S R Wild, K R Palmer
Journal: Gut (1990)

Obstructive jaundice caused by compression of the common hepatic duct by a simple hepatic cyst in a 31 year old Europid man is reported. The jaundice and duct compression resolved after percutaneous aspiration of the cyst under ultrasound direction and the patient has been well for 12 months.
Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease
Authors: Sun Jin Choi, Yasuo Oba, Yair Gazitt, Melissa Alsina, Jose Cruz, Judith Anderson, G. David Roodman
Journal: Journal of Clinical Investigation (2001)

We recently identified macrophage inflammatory protein 1-α (MIP-1α) as a factor produced by multiple myeloma (MM) cells that may be responsible for the bone destruction in MM (1). To investigate the role of MIP-1α in MM bone disease in vivo, the human MM–derived cell line ARH was stably transfected with an antisense construct to MIP-1α (AS-ARH) and tested for its capacity to induce MM bone disease in SCID mice. Human MIP-1α levels in marrow plasma from AS-ARH mice were markedly decreased compared with controls treated with ARH cells transfected with empty vector (EV-ARH). Mice treated with AS-ARH cells lived longer than controls and, unlike the controls, they showed no radiologically identifiable lytic lesions. Histomorphometric analysis demonstrated that osteoclasts (OCLs) per square millimeter of bone and OCLs per millimeter of bone surface of AS-ARH mice were significantly less than in EV-ARH mice, and the percentage of tumors per total bone area was also significantly decreased. AS-ARH cells demonstrated decreased adherence to marrow stromal cells, due to reduced expression of the α5β1 integrin and diminished homing capacity and survival. These data support an important role for MIP-1α in cell homing, survival, and bone destruction in MM.
Comparison of Coronary Thermodilution and Doppler Velocity for Assessing Coronary Flow Reserve
Authors: William F. Fearon, H.M. Omar Farouque, Leora B. Balsam, David T. Cooke, Robert C. Robbins, Peter J. Fitzgerald, Alan C. Yeung, Paul G. Yock
Journal: Circulation (2003)

Thermodilution coronary flow reserve (CFRthermo) is a new technique for invasively measuring coronary flow reserve (CFR) with a coronary pressure wire and is based on the ability of the pressure transducer to also measure temperature changes. Whether CFRthermo correlates well enough with absolute flow-derived CFR (CFRflow) to replace Doppler wire-derived CFR (CFRDoppler) remains unclear.In an open-chest pig model, CFRthermo was measured in the left anterior descending (LAD) artery and compared with CFRDoppler and CFRflow, measured with an external flow probe placed around the LAD. In 9 pigs, CFR was measured simultaneously by all 3 means in the normal LAD and after creation of an epicardial LAD stenosis. To determine the added effect of microvascular disease, measurements of flow reserve were also performed after disruption of the coronary microcirculation with embolized microspheres. Intracoronary papaverine (20 mg) was used to induce hyperemia. In a total of 61 paired measurements, CFRthermo correlated strongly with the reference standard CFRflow (r=0.85, P<0.001). CFRDoppler correlated less well with CFRflow (r=0.72, P<0.001). Bland-Altman analysis showed a closer agreement between CFRthermo and CFRflow.CFRthermo correlates better with CFRflow than does CFRDoppler.
Experience with Thallium-201 Imaging in Head and Neck Cancer
Authors: A H EL-GAZZAR, A SAHWEIL, H M ABDEL-DAYEM, H KUBASIK, R HALKER, I M HASSAN, M JAMIL, A RAGEB, S M ABDUL-RAHIM, A MAHMOUD, Y T OMAR
Journal: Clinical Nuclear Medicine (1988)

TI-201 chloride was used for tumor imaging in patients with head and neck cancer, it is of value in detecting the extent of tumor involvement, the presence of residual tumor after radical courses of treatment, and the presence of local recurrence and distant metastases.
Myopathy in Whipple's disease.
Authors: M Swash, M S Schwartz, M J Vandenburg, D J Pollock
Journal: Gut (1977)

We report a patient with Whipple9s disease who developed a myopathy that improved during antibiotic therapy. The muscle biopsy showed mild type 2 fibre atrophy, type 1 fibre preponderance, variability in fibre size, and changes in the myofibrillar pattern of affected fibres. Interfascicular macrophages contained PAS-positive material. With the electron microscope these macrophages contained membranous inclusions and bacillary bodies, similar to those seen in the jejunal biopsy.
Book Review The Excellent Doctor Blackwell: The Life of the First Female Physician By Julia Boyd. 336 pp., illustrated. Thrupp, England, Sutton Publishing, 2006. $22.95 (cloth); $16.95 (paper). 978-0-750-94140-2 (cloth); 978-0-750-94141-9 (paper).
Authors: Steven G. Friedman
Journal: New England Journal of Medicine (2007)
THE BEST METHODS OF CLOSING ASEPTIC WOUNDS, ESPECIALLY OF THE ABDOMEN.THE USES AND VALUE OF THE BURIED ANIMAL SUTURE.
Authors: HENRY O. MARCY
Journal: JAMA (1906)

To-day's mail brings me an advertisement of a new abdominal supporter especially devised to be used after laparotomy, with the statement that the hospitals are ordering them in quantities. Such advertisements reach the tables of nearly all the members of this section and are indications of their general use. One of the largest hospitals of Boston makes a routine practice of having patients wear an abdominal supporter for one year after operation. The most approved pattern adopted is a kind of reversed corset, especially fitted to the individual. Wherefore the need? It is reported that in this same hospital, notwithstanding all this care, about 10 per cent of the laparotomies are followed by hernia at the site of the wound. A fair critic must arrive at one of the following conclusions: Either that the technic of reunion is faulty, or that the severed portions of the abdominal wall can not
Prediction of Fainting in Blood Donors
Authors: DAVID T. GRAHAM
Journal: Circulation (1961)

Four hundred and fourteen consecutive blood donors to a hospital blood bank were studied to discover items of value in predicting the occurrence of "reactions." Since it is probable that blood donor "reactions" are almost always vasovagal faints, they are so referred to below. Several items of predictive value were found: none of the 62 Negroes, but 63 of the 352 white persons fainted; the younger the donor, the more likely a faint; the higher the resting pulse rate before venipuncture, the more likely a faint; admission of "nervousness" was associated with greater chance of fainting than was denial. Sex, resting blood pressure before venipuncture, and history of previous blood donation did not significantly differentiate fainters from nonfainters. The data are compatible with the hypothesis that vasovagal fainting in blood donors is the second limb of a diphasic response, and is part of relief from anxiety; the first limb is part of anxiety proper.
Diagnosis of Ventilator-Associated Pneumonia
Authors: Marin H. Kollef
Journal: New England Journal of Medicine (2006)

In this issue of the Journal, Heyland et al., writing for the Canadian Critical Care Trials Group, report the results of a multicenter, randomized trial comparing the use of bronchoalveolar lavage and endotracheal aspiration for the diagnosis of ventilator-associated pneumonia.1 This study was part of a larger 2-by-2 factorial design also comparing empirical antimicrobial monotherapy (a carbapenem) and combination therapy (a carbapenem plus a fluoroquinolone). The authors conclude that bronchoalveolar lavage and endotracheal aspiration are associated with similar clinical outcomes and similar overall use of antibiotics. However, several important limitations of the study must be appreciated in order to place . . .
Reactions of immunoglobulin G-binding ligands with platelets and platelet-associated immunoglobulin G.
Authors: W F Rosse, D V Devine, R Ware
Journal: Journal of Clinical Investigation (1984)

Immunoglobulin G (IgG) bound to platelets is usually detected by one of two general methods: binding of labeled anti-IgG or consumption of anti-IgG. The latter method gives, in general, values 5-10-fold greater than the former under the same conditions. To investigate these discrepancies, we have compared the detection of platelet-bound IgG by a labeled anti-IgG binding assay and by a quantitative antiglobulin consumption test using the same antibodies. The interaction of 125I-labeled monoclonal anti-IgG or polyclonal anti-IgG with washed and IgG-coated platelets was studied. The binding of these ligands to washed normal platelets was largely (50-80%) nonspecific; the binding was not saturable and was only partially inhibitable by excess unlabeled anti-IgG. The binding of anti-IgG to platelets coated with anti-PIA1, a platelet-specific IgG antibody, appeared to be saturable and inhibitable; the dissociation constant (KD) of this IgG-anti-IgG reaction was 4.9 X 10(-9) for monoclonal and 1.4 X 10(-7) for polyclonal anti-IgG. The ratio of sites present on the membrane (determined by 131I-labeled anti-PIA1) to the number of binding sites for anti-IgG determined by Scatchard analysis was 0.53 for monoclonal anti-IgG and 1.3 for polyclonal anti-IgG. The binding of monoclonal anti-IgG to platelet-bound immune complexes or IgG aggregates appeared to be complex. 131I-Labeled IgG was affixed to platelets and was detected by three tests: direct binding of radiolabeled monoclonal anti-IgG and quantitative antiglobulin consumption (QAC) tests, which were quantitated either by measuring directly the amount of radiolabeled anti-IgG consumed from fluid phase (direct QAC), or indirectly by reference to a calibration curve relating the consumption of anti-IgG by known amounts of fluid-phase, non-immune IgG (indirect QAC). The amount of platelet-bound IgG detected by the direct binding of 125I-labeled monoclonal anti-IgG and by the direct QAC approximated that known to be bound to the platelet. The results of the indirect QAC test were 10-fold greater. The discrepancy appears to be due to the fact that there is a difference between the IgG-anti-IgG interaction when IgG is bound to a platelet and when it is in solution or bound to plastic nonspecifically or specifically. This difference results in a falsely high value for platelet-bound IgG when fluid-phase or plastic-bound IgG is used to calibrate the antiglobulin consumption test.
Low-Osmolar Contrast Agents
Authors: Morris L. Gavant
Journal: JAMA (1989)

<h3>To the Editor.—</h3> The total adoption of low-ionic contrast media is not likely, given the current economic limitations in this country. However, Dr Fischer's<sup>1</sup>statement in his recent editorial that a universal changeover to these agents is not justified just to increase patient comfort may be misconstrued as a statement, potentially with legal ramifications, that these drugs are not indicated when they are to be used primarily to lessen pain and motion during radiographic procedures. This is certainly not the case. In my practice, I have no doubt that the decrease in the pain that patients experience during intra-arterial injection of high concentrations of the new, more expensive, agents, compared with the intense pain commonly experienced with the older high-osmolality drugs, warrants their routine use for almost all diagnostic and interventional angiographic procedures. I cannot ethically deny their use to my patients, since I would insist on the use
Mitral valvotomy--value of the closed technique.
Authors: E Besterman, L L Bromley
Journal: BMJ (1980)

may be responsible for stress.Though this possibility should not be overlooked, simple observation of increased smoking during war time suggests that smoking alleviates stress or fulfils some other basic human need (for example, relieves boredom) for many people, a view consistent with the US Surgeon-General's recognition of "significant beneficial effects of smoking primarily in the area of mental health."3Dr T Khosla and Professor H Campbell (2 February, p 331) suggested that, by restricting my attentions to those under 65, I had given a
ED-26 * ATYPICAL TERATOID/RHABDOID TUMOR OF THE CENTRAL NERVOUS SYSTEM IN A 27-YEARS OLD PATIENT
Authors: R. Rivas, P. Carrasco, F. Ayach
Journal: Neuro-Oncology (2014)

INTRODUCTION: Atypical Teratoid/Rhabdoid Tumor (ATRT), according to the World Health Organization (WHO) Classification of Tumors, is a highly malignant neoplasm (grade IV) of the Central Nervous System (CNS) that preferentially manifests in children less than three years of age. These tumors are mainly composed of rhabdoid cells, with the addition or not of areas demonstrating characteristics of primitive neuroectodermal tumor. Less than 40 cases were published in the literature about this neoplasm. OBJECTIVE: In this context our aim is to present an unusual case of ATRT. MATERIAL AND METHOD: A 27-year old male, with intellectual disability. He referred headache, nausea and vomiting and was associated with progressive left femoral brachial paresis, so he consulted in the clinic in March 2013. Brain CT and magnetic resonance (MRI) spectroscopy revealed a solid cystic mass in the right temporal medial lobe of 65x57 mm, with an intense contrast (gadolinium) enhancement, the tumor compressed the third ventricles, displacing the midline and deforming the ventricles. RESULTS: The neoplasm was totally excised, histological and immunohistochemical analysis demonstrated atypical rhabdoid cells strongly and diffusely positive for EMA and Vimentin as well as focally immunoreactive for GFAP. The patient was treated with chemotherapy (vincristine) and radiotherapy. The patient finally died in Abril 2014. CONCLUSIONS: Few previous case of ATRT have been reported in adults, thus far. This unusual presentation underlines the necessity of considering this devastating neoplasm in the differential diagnosis of malignant brain tumor of young adults.
Pacing After Shocks Stronger Than the Upper Limit of Vulnerability
Authors: Nipon Chattipakorn, Parwis C. Fotuhi, Catherine M. Sreenan, James B. White, Raymond E. Ideker
Journal: Circulation (2000)

Background —After upper-limit-of-vulnerability (ULV) shocks of the same strength and coupling interval (CI) during the T wave, (1) the epicardial activation pattern (EAP) for the first postshock cycle is indistinguishable between shocks that do (VF) and do not (NoVF) induce ventricular fibrillation (VF) and (2) ≥3 cycles in rapid succession always occur during VF but not during NoVF episodes. To study the role of these rapid cycles, rapid pacing was performed after a shock stronger than the ULV that by itself did not induce rapid cycles and VF. Methods and Results —A 504-electrode sock was sutured to the heart in 6 pigs to map EAPs. The S2 shock strength and S1-S2 CI at the ULV were determined by T-wave scanning with an up/down protocol. Ten shocks 50 to 100 V above the ULV (aULV) were delivered at the same S1-S2 CI to confirm that VF was not induced. Then, the postshock interval after aULV shocks was scanned with an S3 pacing stimulus from the LV apex until the shortest S2-S3 CI that captured was reached. This was repeated for S4, S5, etc, until VF was induced. To induce VF, 3 pacing stimuli (S3-S5) with progressively shorter CIs were required; S3 or S3, S4 never induced VF. After cycle S5, which induced VF, 2 EAP types occurred: focal (74%) and reentrant (26%). Conclusions —At least 3 cycles with short CIs are necessary for VF induction after aULV shocks. Cycles S3-S4 may create the substrate for cycle S5 to initiate VF.
Hyperosmolar non-ketotic diabetes mellitus associated with metolazone.
Authors: P A Rowe, H G Mather
Journal: BMJ (1985)

Psoriasis , alcohol, and liver disease The relations between psoriasis, consumption of alcohol, and liver disease are usually discussed in textbooks in the context of methotrexate hepatotoxicity but have never been studied in a large number of subjects.'The aim of this study was to assess the prevalence of psoriasis according to alcohol consumption and the presence of liver disease.*Significantly greater than prevalence of psoriasis in patients drinking less than 50 g alcohol/day with and without liver disease (p <0001). CommentOur patient had severe hyperglycaemia with little change in serum on 1 August
P14.01 * INTEGRATED GENETIC STUDIES OF NEUROFIBROMATOSIS TYPE 1. A TEN YEAR, ITALIAN EXPERIENCE
Authors: D. Bianchessi, S. Morosini, C. Ibba, S. Esposito, V. Saletti, D. Riva, F. Natacci, G. Finocchiaro, M. Eoli
Journal: Neuro-Oncology (2014)

BACKGROUND: Neurofibromatosis type 1 (NF1) is a human autosomal dominant disorders that affects approximately 1 in 3,500 individuals worldwide. The most common features of NF1 are pigmentary abnormalities, such as café-au-lait macules, skinfold freckling, Lisch nodules and cutaneous and plexiform neurofibromas (PNs). These signs are age-dependent and present high variability in penetrance and expressivity even between affected members of a family. NF1 is the most common cancer predisposing syndrome affecting the nervous system. Glioma is the most common central nervous system neoplasia in NF1 patients: 15-20% NF1 children develop low grade optic gliomas. PNs occur in 30% of NF1 patients in peripheral nervous system. Patients with PNs have a 20-fold higher risk of developing malignant peripheral nerve sheath tumours (MPNSTs) than other NF1 patients. NF1 is caused by mutations in the neurofibromin gene encoding a negative regulator of Ras guanosine triphosphate (GTP)ase proteins: for this reason is considered a tumor suppressor gene. Mutation detection in the NF1 gene is complex, due to the large size of the gene (>350 kb), the presence of pseudogenes, the lack of hot spots, and the great variety of possible mutations. Hence, the clinical and molecular diagnosis of NF1 may be challenging and its fine-tuning is desirable. METHODS: During 2003-2013 NF1 mutation analysis of genomic DNA was performed in 458 patients using the multiplex ligation-dependent probe amplification (MLPA) to look for deletions or insertions located inside the NF1 gene. Subjects who tested negative for MLPA were investigated using denaturing high pressure liquid chromatography (DHPLC) and sequencing DNA. RNA-based cDNA-PCR sequencing was used in a limited group of patients. RESULTS: 299 of 458 patients were diagnosed according to NIH criteria. 54% were children and about 53% of all NF1 patients were found to have sporadic mutations. We identified 197 single mutations and more than 57% were novel. This genetic protocol permitted us to find mutations in 210 of 299 of clinically diagnosed patients (detection rate: 70%). To improve such detection rate we have recently developed a sensitive, integrated genetic protocol using MLPA and RNA-based cDNA-PCR sequencing. This protocol was validated in a cohort of 33 blood samples from NF1 patients with complete NF1 features, identifying the mutations in 30 cases (91% detection rate). CONCLUSIONS: These data suggest that integrated DNA/RNA-based protocols can improve detection rate in patients suspected to have NF1.
Progressive Systemic Sclerosis and Meralgia Paraesthetica
Authors: Julie Kaufmann, Juan J. Canoso
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 December 1986Progressive Systemic Sclerosis and Meralgia ParaestheticaJULIE KAUFMANN, M.D, JUAN J. CANOSO, M.DJULIE KAUFMANN, M.DSearch for more papers by this author, JUAN J. CANOSO, M.DSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-6-973_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A patient recently came to us with a burning pain in her left anterolateral thigh. She had a long history of progressive systemic sclerosis characterized by Raynaud's phenomenon, cutaneous calcifications, telangiectases, dysphagia, interstitial lung disease, and lack of skin involvement. The onset of pain correlated with attacks of intestinal pseudo-obstruction and abdominal distention associated with her primary disease. When present, this pain was exacerbated by standing and relieved by lying down.The association between meralgia paraesthetica and large abdomens in pregnancy, obesity, and ascites has been described (1). In a previous report on thigh pressures measured during...References1. KITCHENSIMPSON CJ. Meralgia paresthetica: a review of 67 patients. Acta Neurol Scand. 1972;48:547-55. CrossrefMedlineGoogle Scholar2. DEALCANOSO CJ. Meralgia paresthetica and large abdomens [Letter]. Ann In tern Med. 1982;96:787-8. AbstractGoogle Scholar3. BOYCE J. Meralgia paresthetica and tight trousers [Letter]. JAMA. 1984;251:1553. CrossrefMedlineGoogle Scholar4. ORTON D. Meralgia paresthetica from a wallet [Letter]. JAMA. 1984;252:3368. CrossrefMedlineGoogle Scholar5. SHALEVCHARNILESMARGALIOT RJS. Meralgia paresthetica in aviation [Letter]. Aviat Space Environ Med. 1982;53:290. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVasculitic Neuropathies and Neuropathies of Connective Tissue DiseasesPostpartum Neuralgic Amyotrophy With Involvement of the Anterior Interosseous NerveSCLERODERMA AND PREGNANCYDas Paar und die LiebeNeurological complications of systemic sclerosis-a report of three cases and review of the literatureMeralgia Paresthetica and HypothyroidismGuillermo Suarez, MD, Thomas D. Sabin, MD 1 December 1986Volume 105, Issue 6Page: 973-973KeywordsAbdominal painAscitesDeceptionDysphagiaInterstitial lung diseasesObesityPainPregnancyRaynaud syndromeScleroderma Issue Published: 1 December 1986 PDF downloadLoading ...
722-3 Low Dose Dobutamine Predicts Recovery of Global but not Regional Left Ventricular Function After Revascularlzatlon In Patients with Chronic Ischemic Dysfunction
Authors: Carolyn L. Donovan, Anne Hepner, David S. Bach, G. Michael Deeb, Steven F. Bolling, Louis A. Brunsting, William F. Armstrong
Journal: Journal of the American College of Cardiology (1995)
Women in Labour
Authors: G. Rowntree
Journal: BMJ (1945)

<h3>Abstract</h3> Little is known about the MIS-C risk with different SARS-CoV-2 variants. In Southeast England, MIS-C rates per confirmed SARS-CoV-2 infections in 0-16 years-olds were 56% lower (rate ratio, 0.34; 95%CI, 0.23-0.50) during pre-vaccine Delta, 66% lower (0.44; 0.28-0.69) during post-vaccine Delta and 95% lower (0.05; 0.02-0.10) during the Omicron period.