tbuckley/cabot-search huggingface dataset:
Three people are evacuated from Homs as talks to secure a Syrian ceasefire flounder
Authors: A. Gulland
Journal: BMJ (2012)

Just three people, including a pregnant woman, have been evacuated from the worst of the fighting in the city of Homs in Syria, the International Committee of the Red Cross has said.

On the evening of Monday 27 February the team of volunteers from the Red Cross and the Syrian Arab Red Crescent entered Baba Amr, the heavily bombarded district of Homs, where the Sunday Times journalist Marie Colvin and French photographer Remi Ochlik were killed last week.

The Red Cross and Red Crescent volunteers distributed medical supplies, as well as evacuating the pregnant woman, her husband, and an elderly woman.

A Red Cross spokesman in Damascus, Saleh Dabbekah, said that the organisations would have liked to have got more …
Biological Significance of Anti–Cyclic Citrullinated Peptide Antibody in Rheumatoid Arthritis
Authors: Daniel G. Arkfeld
Journal: Annals of Internal Medicine (2008)

Letters4 March 2008Biological Significance of Anti–Cyclic Citrullinated Peptide Antibody in Rheumatoid ArthritisDaniel G. Arkfeld, MDDaniel G. Arkfeld, MDFrom the University of Southern California Keck School of Medicine, Los Angeles, CA 90033.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-5-200803040-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read the article by Nishimura and colleagues (1) with great interest. The use of anti-CCP testing makes RA diagnosis more accurate, which allows earlier detection in an attempt to avoid joint damage. However, the study has 3 potential pitfalls. First, up to 20% of new patients with RA are seronegative in the first year, when early diagnosis is essential to prevent erosive joint disease. It would have been helpful to see the anti-CCP data during the first, vitally important year of disease. Other modalities, such as magnetic resonance imaging and ultrasonography, play a role in the ...Reference1. Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, Kawano S, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007;146:797-808. [PMID: 17548411] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of Southern California Keck School of Medicine, Los Angeles, CA 90033.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-analysis: Diagnostic Accuracy of Anti–Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis Kunihiro Nishimura , Daisuke Sugiyama , Yoshinori Kogata , Goh Tsuji , Takashi Nakazawa , Seiji Kawano , Katsuyasu Saigo , Akio Morinobu , Masahiro Koshiba , Karen M. Kuntz , Isao Kamae , and Shunichi Kumagai Biological Significance of Anti–Cyclic Citrullinated Peptide Antibody in Rheumatoid Arthritis Kunihiro Nishimura , Akio Morinobu , and Shunichi Kumagai Biological Significance of Anti–Cyclic Citrullinated Peptide Antibody in Rheumatoid Arthritis Ronenn Roubenoff , Evan Beckman , Michael Weinblatt , Nancy Shadick , and Peter K. Gregersen Metrics Cited ByDiagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients 4 March 2008Volume 148, Issue 5Page: 403KeywordsConflicts of interestGoutMagnetic resonance imagingProteinsRheumatoid arthritisUltrasound imaging ePublished: 4 March 2008 Issue Published: 4 March 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Onycholysis Associated With Carcinoma of the Lung
Authors: Jack W. Hickman
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Onycholysis, or separation of the nail from its bed, occurs most frequently with localized infections of the nails. It has also been reported in association with a number of systemic illnesses. I believe that it has not been reported to occur with carcinoma of the lung, as was found in the following patient. <h3>Report of a Case.—</h3> A 45-year-old man was admitted to the Tampa Veterans Administration Hospital in September 1976 because of a seizure disorder. A poorly differentiated squamous cell carcinoma of the lung had been diagnosed in May 1976, and the patient had received radiotherapy because the lesion was judged to be inoperable. Physical examination showed essentially normal vital signs. The patient had an expressive aphasia. His thyroid was not enlarged. A right thoracotomy scar was present, and there were decreased breath sounds and dullness over the right hemithorax. Palsies of right cranial nerves VII
Fetal cardiovascular morphology of truncus arteriosus with or without truncal valve insufficiency in the rat.
Authors: K Momma, M Ando, A Takao, S Miyagawa-Tomita
Journal: Circulation (1991)

Recent advances in fetal echocardiography have necessitated further study on fetal in situ cardiovascular morphology of truncus arteriosus and the effects of truncal valve insufficiency.We studied 55 fetal rats with truncus arteriosus among 300 fetuses from 40 virgin females treated with 200 mg fertilysin on the 10th day of pregnancy. After rapid whole-body freezing on the 21st day, the fetuses were studied by means of serial cross-sectional photographs of the frozen thorax. Thirty-five fetuses with a normal heart treated with fertilysin served as controls. Truncus arteriosus was characterized by a large ventricular septal defect, a solitary artery (truncus arteriosus) overriding the ventricular septum, the right and left pulmonary arteries originating from the truncus arteriosus with or without a common trunk (main pulmonary artery), and absent ductus arteriosus. Fetuses with truncal valve insufficiency had thick truncal valves, a large truncus arteriosus, and large ventricles. The subgroup of 12 fetuses with a large truncus (truncal diameter greater than 160% of the ascending aorta diameter in the controls) showed significantly greater values for right ventricular volume (200% of control) and mass (120% of control), left ventricular volume (170% of control) and mass (110% of control), right (120% of control) and left (110% of control) atrial volume, and pericardial fluid (140% of control) than the controls. These changes were less prominent and ventricular volumes were not increased in the remaining subgroup with a truncal diameter of 160% or less of aorta diameter in the controls.In fetal truncus arteriosus, truncal valve insufficiency was associated with increased ventricular volume load and incomplete cardiac compensation in rats.
Targeted Gene Modification of Hematopoietic Progenitor Cells in Mice Following Systemic Administration of a PNA-peptide Conjugate
Authors: Faye A Rogers, Sharon S Lin, Denise C Hegan, Diane S Krause, Peter M Glazer
Journal: Molecular Therapy (2011)

Hematopoietic stem cell (HSC) gene therapy offers promise for the development of new treatments for a variety of hematologic disorders. However, efficient in vivo modification of HSCs has proved challenging, thus imposing constraints on the therapeutic potential of this approach. Herein, we provide a gene-targeting strategy that allows site-specific in vivo gene modification in the HSCs of mice. Through conjugation of a triplex-forming peptide nucleic acid (PNA) to the transport peptide, antennapedia (Antp), we achieved successful in vivo chromosomal genomic modification of hematopoietic progenitor cells, while still retaining intact differentiation capabilities. Following systemic administration of PNA-Antp conjugates, sequence-specific gene modification was observed in multiple somatic tissues as well as within multiple compartments of the hematopoietic system, including erythroid, myeloid, and lymphoid cell lineages. As a true functional measure of gene targeting in a long-term renewable HSC, we also demonstrate preserved genomic modification in the bone marrow and spleen of primary recipient mice following transplantation of bone marrow from PNA-Antp-treated donor mice. Our approach offers a minimally invasive alternative to ex vivo gene therapy, by eliminating the need for the complex steps of stem cell mobilization and harvesting, ex vivo manipulation, and transplantation of stem cells. Therefore, our approach may provide new options for individualized therapies in the treatment of monogenic hematologic diseases such as sickle cell anemia and thalassemia.
An unusual papular and acneiform facial eruption in the negro child
Authors: R. H. MARTEN, D. G. C. PRESBURY, J. E. ADAMSON, B. S. CARDELL
Journal: British Journal of Dermatology (1974)

Journal Article An unusual papular and acneiform facial eruption in the negro child Get access R. H. MARTEN, R. H. MARTEN Departments of Dermatology and Pathology, King's College Hospital, Denmark Hill, London, S. E.5 Search for other works by this author on: Oxford Academic Google Scholar D. G. C. PRESBURY, D. G. C. PRESBURY Departments of Dermatology and Pathology, King's College Hospital, Denmark Hill, London, S. E.5 Search for other works by this author on: Oxford Academic Google Scholar J. E. ADAMSON, J. E. ADAMSON Departments of Dermatology and Pathology, King's College Hospital, Denmark Hill, London, S. E.5 Search for other works by this author on: Oxford Academic Google Scholar B. S. CARDELL B. S. CARDELL Departments of Dermatology and Pathology, King's College Hospital, Denmark Hill, London, S. E.5 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue 4, 1 October 1974, Pages 435–438, https://doi.org/10.1111/j.1365-2133.1974.tb13083.x Published: 01 October 1974 Article history Accepted: 07 January 1974 Published: 01 October 1974
Calcium sensitivity of isometric force in intact and chemically skinned aortas during the development of aldosterone-salt hypertension in the rat.
Authors: E G McMahon, R J Paul
Journal: Circulation Research (1985)

We investigated the role of altered vascular calcium handling in the development of aldosterone-salt hypertension in the rat. The calcium sensitivity of isometric force in response to 50 mM KCl was compared in aortic rings from control and aldosterone-hypertensive rats. Over the entire range of calcium concentrations studied, responses in aortas from the hypertensives were significantly depressed compared to controls [ED50: aldosterone-hypertensive rats (n = 6), 0.739 +/- 0.137; controls (n = 7), 0.141 +/- 0.021 mM; P less than 0.001]. However, calcium sensitivity in response to 1 microM norepinephrine was similar in aortas from both hypertensives and controls [ED50: aldosterone-hypertensive rats (n = 7), 0.196 +/- 0.022; controls (n = 7), 0.180 +/- 0.024 mM]. The calcium sensitivity of Triton X-100 skinned aortic rings from aldosterone-hypertensive rats was likewise not significantly different from sensitivity in controls [ED50: aldosterone-hypertensive rats (n = 9), 3.61 X 10(-7) +/- 0.57; controls (n = 8), 3.89 X 10(-7) +/- 0.64 M]. Therefore, the observed decrease in calcium sensitivity in response to membrane depolarization in aortas from aldosterone-hypertensive rats probably is not due to a change in calcium sensitivity of the contractile system itself. The time course for development of changes in calcium handling in vessels from the aldosterone-hypertensive rats was found to be quite different from the time course for changes in monovalent ion metabolism. Whereas increases in monovalent ion permeability reportedly appear as early as one week after the start of aldosterone-salt treatment, significant alterations in calcium handling were not apparent until after four weeks of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Textbook of Family Practice
Authors: D. Mark Mahler
Journal: JAMA (1985)

The<i>Textbook of Family Practice</i>has been expanded and completely revised in this third edition. Forty-five percent of the 71 chapters are new titles, and most of the chapters have new authors. The book thus stands as a companion to the previous edition.<sup>1</sup>The primary purpose of the text is "to assist practicing family physicians in providing [high] quality medical care for their patients" (preface). The book is also intended as a reference for family practice residents and students. The work is oriented toward a traditional office practice of family medicine. It consists of six parts: "Principles of Family Medicine," "Community Medicine," "Research in Family Medicine," "Communication in Family Medicine," "Practice of Family Medicine," and "Management of the Practice." Most chapters are coauthored by a family physician and a subspecialist. Discussions tend to be clear, concise, and practically oriented yet with adequate theoretical base, but often lacking in thoroughness.
PREVIOUS HAMSTRING INJURY REDUCES PRE-SEASON IMPROVEMENTS IN ECCENTRIC STRENGTH IN ELITE AUSTRALIAN FOOTBALL PLAYERS
Authors: A Shield
Journal: British Journal of Sports Medicine (2014)

Background Eccentric strength training can reduce hamstring strain injuries (HSIs), although a persistent neuromuscular inhibition after injury may reduce the trainability of this muscle group. Objective To test the a priori hypothesis that previous HSI results in a reduced increase in eccentric strength during pre-season training in elite AFL players. Design Case controlled observational study. Players with unilateral HSI, confirmed by MRI within the previous 12 months were compared with players who had no HSI. Setting 5 elite Australian football teams from the AFL. Participants 103 players were recruited, 28 of whom had sustained unilateral HSI in the previous 12 months. Others were free of lower limb injuries that may have influenced knee flexor strength. Risk factor assessment The categorical independent variable was the existence of HSI in the 12 months prior to the study (yes or no). Main outcome measurements Eccentric knee flexor strength gain in the preseason training period. Eccentric strength was measured as knee flexion forces at the ankles during the performance of the Nordic hamstring exercise. Results ANCOVA on changes in strength indicated that players with recent HSI made less progress in eccentric hamstring strength (–30 N; CI=-57 to –4 N; P=.0266) than those without HSI. This muted strength gain was observed in both the previously injured (13±61 N) and uninjured limbs (10±64 N) of players who had sustained unilateral injury. Conclusions Players with recent unilateral HSI exhibited reduced eccentric knee flexor strength gains in both limbs. The mechanism for this is unknown. Additional research should focus on both the reason for this diminished progress and on how to improve eccentric strength in footballers who have suffered hamstring strains.
MICROSPORCM EQELNEM INFECTION OF THE SCALP IN AN ADULT
Authors: K. J. O'GRADY, M. P. ENGLISH, R. P. WARIN
Journal: British Journal of Dermatology (1972)

Journal Article MICROSPORCM EQELNEM INFECTION OF THE SCALP IN AN ADULT Get access K. J. O'GRADY, K. J. O'GRADY Department of Dermatology Dental Bristol Hospitals Search for other works by this author on: Oxford Academic Google Scholar M. P. ENGLISH, M. P. ENGLISH Department of Dermatology Dental Bristol Hospitals Search for other works by this author on: Oxford Academic Google Scholar R. P. WARIN R. P. WARIN Department of Dermatology Dental Bristol Hospitals Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue 2, 1 February 1972, Pages 175–176, https://doi.org/10.1111/j.1365-2133.1972.tb16083.x Published: 01 February 1972 Article history Accepted: 22 September 1971 Published: 01 February 1972
Extending the clinical research network approach to all of healthcare
Authors: J. Darbyshire, J. Sitzia, D. Cameron, G. Ford, S. Littlewood, R. Kaplan, D. Johnston, D. Matthews, J. Holloway, N. Chaturvedi, C. Morgan, A. Riley, M. Rossor, P. Kotting, I. McKeith, S. Smye, J. Gower, V. Brown, R. Smyth, V. Poustie, W. van't Hoff, P. Wallace, T. Ellis, T. Wykes, S. Burns, W. Rosenberg, N. Lester, M. Stead, V. Potts, C. Johns, H. Campbell, R. Hamilton, J. Sheffield, P. Selby
Journal: Annals of Oncology (2011)
Campaign to revitalise academic medicine: Crisis in UK academia affects academic medicine too
Authors: Alistair R Fielder, Michael Levin
Journal: BMJ (2004)

EDITOR—Academic medicine is in a woeful state.1–3 But this is only part of the crisis affecting UK academia as a whole. Pumping funds into academic medicine alone1–4 without tackling fundamental issues would only worsen the situation.

“Top class researchers make excellent teachers, and students benefit from the enhanced quality of the education they receive.”5 But the assessment of …
Marcumar [3-(l'-phenyl-propyl)-4-hydroxy-coumarin]. A New Anticoagulant
Authors: RENÉ BOURGAIN, MARGARET TODD, LORRAINE HERZIG, IRVING S. WRIGHT
Journal: Circulation (1954)

Marcumar [3-(1'-phenyl-propyl)-4-hydroxycoumarin] is a new anticoagulant. Marcumar acts more rapidly than Dicumarol, but not quite as rapidly as Tromexan. The action is more prolonged than Dicumarol. As with other anticoagulants, the administration of Marcumar requires conscientious observation and accurate prothrombin complex determinations.
Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions
Authors: PJ Duggan, EF Maalouf, TL Watts, MHF Sullivan, SJ Counsell, J Allsop, L Al-Nakib, MA Rutherford, M Battin, I Roberts, AD Edwards
Journal: The Lancet (2001)
Ethanol-induced increase in portal hepatic blood flow: Interference by anesthetic agents
Authors: Frederick J. Carmichael, Victor Saldivia, Yedy Israel, John P. McKaigney, Hector Orrego
Journal: Hepatology (1987)

While a number of studies show that acute oral administration of ethanol results in increases in liver blood flow, a large body of evidence has also been presented in which such an effect is not observed. To shed light on this discrepancy, we have studied in rats, a number of variables that might modulate or inhibit the effect of ethanol. These included the use of three anesthetic agents studied at two different times after anesthetic administration and the effect of animal age, gender, batches and seasonal variation. Portal blood flows were determined by the radiolabeled microsphere method in 12 separate experiments in awake rats. Ethanol given at doses ranging from 0.5 to 4.0 gm per kg consistently increased portal vein blood flow by approximately 50% (42.2 ± 3.5 to 63.4 ± 6.5 ml per min per kg). The interexperiment variation was 2.4 to 3.0%, showing remarkable consistency, typical of an all-or-none effect at the doses employed. On the other hand, the ethanol-induced increase in portal blood flow was completely suppressed by ketamine (75 mg per kg), thiopental (50 mg per kg) and fentanyl (15 μg per kg) when given 15 min prior to blood flow determinations. This suppression was dependent on the dose and duration of anesthesia. These anesthetic agents had no effect on basal hepatic arterial or portal blood flows. Ethanol or the anesthetics were without effects on hepatic artery blood flow. Neither gender, weight (150 to 350 gm) nor animal batch had effect on the response to ethanol. Similarly, there was no effect of seasonal variation. The increase in portal vein blood flow following a dose of 2 gm per kg of ethanol disappeared only after 6 hr when blood levels of ethanol had decreased to concentrations below 3 mM. The consistency, under nonpathological conditions, of an increase in portal blood flow by ethanol is of interest because, as ethanol also increases liver oxygen consumption, an increment in oxygen delivery induced by ethanol could play a compensatory role preventing the occurrence of hypoxic liver damage.
EFFECT OF INTRANASAL GLUCAGON ON BLOOD GLUCOSE LEVELS IN HEALTHY SUBJECTS AND HYPOGLYCAEMIC PATIENTS WITH INSULIN-DEPENDENT DIABETES
Authors: L. Freychet, N. Desplanque, P. Zirinis, S.W. Rizkalla, A. Basdevant, G. Tchobroutsky, G. Slama
Journal: The Lancet (1988)
Risk of anicteric hepatitis following blood transfusion.
Authors: B N Somayaji, W D Stone, P B Glover
Journal: Gut (1967)

COMMENT The considerable risk of overt or anicteric hepatitis following blood trans- fusion reported from various countries has not been confirmed in England.This may be due to the careful selection of blood donors and to the fact that they are volunteers.Volunteers are known to have a lower incidence of silent virus carriers than professional donors.Serum hepatitis can be a serious complication ofblood transfusion, and it is possible that even mild attacks may lead to cirrhosis, although evidence for this is scanty.The incidence of icteric hepatitis following blood transfusion was found to be 0-8 % in Liverpool by Lehane, Kwantes, Upward, and Thomson (1949), but in other countries higher figures have been obtained.For example, Katz, Ducci, Bennett, and Rodriguez (1957) reported an incidence of over 4% in Chile, while in the U.S.A. it was 3 % (Allen and Sayman, 1962) and 4 % (Mirick, Ward, and McCollum, 1965) in two large series.The anicteric form of hepatitis, diagnosed on the basis of raised serum transaminases and sometimes confirmed by biopsy, appears to be much more common.It has been suggested that it occurs be- tween 10 (Shimizu and Kitamoto, 1963) and 100 times (Hampers, Prager, and Senior, 1964) as often as hepatitis with jaundice, the diagnosis being made in 13-5 % of transfused patients in a German report (Creutzfeldt, 1966) and in 64 5 % in one from Japan (Shimizu and Kitamoto, 1963) (see table).In the Philadelphia series (Hampers et al., 1964) all patients who received 6 or more units of blood contracted hepatitis.We report below the findings of a study, carried out in an attempt to assess the importance of this complication, in the Birmingham region. PATIENTS AND METHODSForty-five patients were studied.Two received blood transfusion for bleeding peptic ulcer, and the remainder were inpatients in the gynaecological wards.Their dis- orders included abortions, fibroids, dysfunctional uterine bleeding, and ruptured ectopic pregnancy.Those with carcinoma were excluded.Patients who had no clinical
Acute Changes in Oxyhemoglobin Affinity EFFECTS ON OXYGEN TRANSPORT AND UTILIZATION
Authors: Thomas E. Riggs, A. William Shafer, Clarence A. Guenter
Journal: Journal of Clinical Investigation (1973)

It has been postulated that 2,3-diphosphoglycerate (DPG)-mediated changes in oxyhemoglobin affinity play an important role in oxygen delivery; however, the effect of an acute increase in affinity without changing red cell mass has not been systematically evaluated. This study was designed to measure changes in oxygen transport and oxygen consumption produced by an acute increase in oxyhemoglobin affinity caused by an autologous exchange transfusion using DPG-depleted stored blood.