"Purple Toes": an Uncommon Sequela of Oral Coumarin Drug Therapy
Authors: WALTER FEDER
Journal: Annals of Internal Medicine (1961)

Article1 December 1961"Purple Toes": an Uncommon Sequela of Oral Coumarin Drug TherapyWALTER FEDER, M.D., ROBERT AUERBACH, M.D.WALTER FEDER, M.D., ROBERT AUERBACH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-6-911 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe utility of coumarin type anticoagulants during the acute stage of many types of thrombo-embolic incidents, including myocardial infarction, has been well established clinically. More recently, the efficacy of these drugs for long-term prophylaxis has also been shown to be of value (1-4), and there is an increasing population of patients on long-term oral anticoagulant therapy. The purpose of this paper is to describe a dermatologic side effect of such therapy, which, to the best of our knowledge, has not been reported previously.Our attention was directed to six patients who developed a dark blue-tinged bilateral purple discoloration of the...References1. BJERKLUND CJ: The Effect of Long-term Treatment with Dicumarol in Myocardial Infarction. Thesis published by Oslo University Press, Oslo, 1957, pp. 1-212. Google Scholar2. BRITISH MEDICAL RESEARCH COUNCIL: An assessment of long-term anticoagulant administration after cardiac infarction. Brit. Med. J. 1: 803, 1959. CrossrefMedlineGoogle Scholar3. MANCHESTER B: The prevention of myocardial infarction. Arch. Intern. Med. 100: 959, 1957. CrossrefGoogle Scholar4. BORCHGREVNIK CF: Long-term anticoagulant therapy in angina pectoris and myocardial infarction. Acta Med. Scand. Vol. 168, Supp. 359, 1960. Google Scholar5. SHEPSGIFFORD SGRW: Urticaria after administration of warfarin sodium. Amer. J. 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Author, Article, and Disclosure InformationAuthors: WALTER FEDER, M.D.; ROBERT AUERBACH, M.D.From the Department of Medicine, University of Chicago, Chicago, Illinois.Requests for reprints should be addressed to Walter Feder, M.D., Department of Medicine, University of Chicago, 950 East 59th Street, Chicago 37, Illinois. 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LACY, M.D., ROBERT R. GOODIN, M.D., F.A.C.C.Disseminated intravascular coagulationWarfarin TherapyCase 25-1967Cholesterol Embolization 1 December 1961Volume 55, Issue 6Page: 911-917KeywordsAnticoagulant therapyAnticoagulantsCoumarinsDrug therapyGratitudeHemorrhageLesionsMyocardial infarctionOral medicineProphylaxis ePublished: 1 December 2008 Issue Published: 1 December 1961 PDF downloadLoading ...