tbuckley/cabot-search huggingface dataset:
Immune Complex Assays in Rheumatoid Disorders
Authors: GARY M. KAMMER
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 February 1981Immune Complex Assays in Rheumatoid DisordersGARY M. KAMMER, M.D.GARY M. KAMMER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-2-275_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their study of vasculitis complicating rheumatoid arthritis, Abel and associates (1) pointed out that circulating immune complexes are temporarily associated with clinical features of vasculitis and that circulating immune complexes may, in part, mediate the pathophysiology of rheumatoid arthritis. Thus, this study confirms previous work that showed circulating immune complexes in rheumatoid arthritis, noted the general relation between disease activity and the presence of complexes, and suggested a role for such complexes in rheumatoid arthritis (2, 3).However, this paper also indirectly raises the issue of the actual clinical utility of immune complex assays in the...References1. ABELANDREWSCUNNINGHAMBRUNNERDAVISHORWITZ TBPCJD. Rheumatoid vasculites: effect of cyclophosphamide on the clinical course and levels of circulating immune complexes. Ann Intern Med. 1980;93:407-13. LinkGoogle Scholar2. LUTHRAMCDUFFIEHUNDERSAMAYOA HFGE. Immune complexes in sera and synovial fluids of patients with rheumatoid arthritis: radioimmunoassay with monclonal rheumatoid factor. J Clin Invest. 1975;56:458-66. CrossrefMedlineGoogle Scholar3. ZUBLERNYDEGGERPERRIN RUL. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis: Correlating of 125I-Clq binding activity with clinical and biological features of the disease. J Clin Invest. 1976;57:1308-19. CrossrefMedlineGoogle Scholar4. ANDERSONSTILLMAN CW. Raji cell assay for immune complexes: evidence for detection of Raji-directed immunoglobulin G antibody in sera from patients with systemic lupus erythematosus. J Clin Invest. 1980;66:353-60. CrossrefMedlineGoogle Scholar5. KAMMERSOTERSCHUR GNP. Circulatory immune complexes in patients with necrotizing vasculitis. Clin Immunol Immunopathol. 1980;15:658-72. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmune Complexes in Man: Detection and Clinical SignificanceCOMPARISON of five assays for immune complexes in the RHEUMATIC DISEASES. An Assessment of Their Validity for Rheumatoid Arthritis 1 February 1981Volume 94, Issue 2Page: 275-275KeywordsImmune complexRheumatoid arthritisVasculitis Issue Published: 1 February 1981 PDF DownloadLoading ...
Detection of occult cobalamin deficiency by magnetic resonance imaging
Authors: Margaret K. Yu, George M. Rodgers
Journal: American Journal of Hematology (2000)

We present a case of cobalamin deficiency in an elderly woman who presented with peripheral neuropathy without evidence of anemia or macrocytosis; her diagnosis was suspected with cervical magnetic resonance imaging. This imaging modality may identify patients with cobalamin deficiency who have neurologic abnormalities with normal hematologic parameters. Am J. Hematol. 65:83–84, 2000. © 2000 Wiley-Liss, Inc.
PROCYCLIDINE AND BENZTROPINE METHANESULFONATE COMPARED IN DRUG INDUCED EXTRAPYRAMIDAL REACTIONS
Authors: ROBIE T. CHILDERS
Journal: American Journal of Psychiatry (1962)

Seventy patients on acute intensive treatment with chlorpromazine, trifluoperazine, and fluphenazine were placed at random in two groups. Group A treated with benztropine methanesulfonate had 40 extrapyramidal symptoms of which 35 improved. Blurred vision or dry mouth developed in 17 instances. Group B treated with procyclidine had 40 extrapyramidal symptoms of which 39 improved with the development of only one side effect—blurred vision—in two patients. On the basis of this study it appears that procyclidine was the most effective drug in alleviating extrapyramidal symptoms. The number of side effects developing with procyclidine were at a minimum.
Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure
Authors: Toshio Miyata, Yoshinao Wada, Zhe Cai, Yoshiyasu Iida, Katsunori Horie, Yoshinari Yasuda, Kenji Maeda, Kiyoshi Kurokawa, Charles Van Ypersele De Strihou
Journal: Kidney International (1997)
Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis
Authors: Maresa Caunt, Judy Mak, Wei-Ching Liang, Scott Stawicki, Qi Pan, Raymond K. Tong, Joe Kowalski, Calvin Ho, Hani Bou Reslan, Jed Ross, Leanne Berry, Ian Kasman, Constance Zlot, Zhiyong Cheng, Jennifer Le Couter, Ellen H. Filvaroff, Greg Plowman, Franklin Peale, Dorothy French, Richard Carano, Alexander W. Koch, Yan Wu, Ryan J. Watts, Marc Tessier-Lavigne, Anil Bagri
Journal: Cancer Cell (2008)
Response of the Timeless Protein to Light Correlates with Behavioral Entrainment and Suggests a Nonvisual Pathway for Circadian Photoreception
Authors: Zhaohai Yang, Mark Emerson, Henry S Su, Amita Sehgal
Journal: Neuron (1998)

The period (per) and timeless (tim) genes are required for circadian behavioral rhythms in Drosophila. The current model for how these rhythms entrain to light is based upon the light induced decrease in timeless protein (TIM) levels. We show here that the TIM response to light correlates with the effect of light on the behavioral rhythm. To identify components of the entrainment pathway, we also assayed the TIM response in flies with mutant visual systems. Flies that lacked eyes displayed a normal response in lateral neurons. The TIM response to a light pulse was attenuated in flies that were mutant for the transient receptor potential (trp) and trp-like (trpl) genes, which are required for calcium conductance in the visual transduction cascade. The reduced TIM response was accompanied by a reduced phase shift in the behavioral rhythm, but neither response was completely eliminated, and the trpl;trp flies entrain to light–dark cycles, suggesting that these genes perturb some aspect of circadian entrainment when mutated but are not essential for it. The TIM response was also unaffected in ninaE flies that lack the rhodopsin protein (rh1). These results support the hypothesis that circadian entrainment does not rely on the visual system and likely involves a dedicated pathway for photoreception.
Training of Rescue Personnel in Closed-Chest Cardiac Resuscitation
Authors: Charles H. Weingarten, Leon J. Taubenhaus
Journal: New England Journal of Medicine (1964)

THE development of closed-chest cardiac resuscitation has given a second chance at life to many victims of sudden cardiac arrest in hospitals throughout the world.1 2 3 4 The extension of this second chance to cases occurring outside the hospital, however, has not followed as rapidly as some had initially anticipated.5 Although a physician occasionally witnesses an episode of cardiac arrest outside the hospital, more often he cannot reach the victim and attempt resuscitation within the time limit imposed by cerebral anoxia. Nonmedical rescue personnel are frequently available in time, but dissemination of cardiac-resuscitation technics to these groups has been impeded by the . . .
[485] ROLE OF HBV GENOTYPES, CORE PROMOTER/PRECORE MUTATIONS AND HBVDNA LEVELS ON HEPATOCARCINOGENESIS
Authors: M.F. Yuen, Y. Tanaka, N. Shinkai, R.T. Poon, J. Fung, O.K. Wong, I.C. Yuen, M. Mizokami, C.L. Lai
Journal: Journal of Hepatology (2007)
Expected and Unanticipated Consequences of the Quality and Information Technology Revolutions
Authors: Robert M. Wachter
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dural Arteriovenous Fistula at the Craniocervical Junction Mimicking Acute Brainstem and Spinal Cord Infarction
Authors: Elliott Salamon, Athos Patsalides, Y. Pierre Gobin, Alejandro Santillan, Matthew E. Fink
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Expression of Concern: Bombardier et al., “Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis,” N Engl J Med 2000;343:1520-8.
Authors: Gregory D. Curfman, Stephen Morrissey, Jeffrey M. Drazen
Journal: New England Journal of Medicine (2005)

Editorial from The New England Journal of Medicine — Expression of Concern: Bombardier et al., "Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis," N Engl J Med 2000;343:1520-8.
Glucagon-like Peptide 1–Receptor Scans to Localize Occult Insulinomas
Authors: Damian Wild, Helmut Mäcke, Emanuel Christ, Beat Gloor, Jean Claude Reubi
Journal: New England Journal of Medicine (2008)

The precise localization of some insulinomas with the use of conventional imaging techniques is a challenging clinical problem. These findings indicate that GLP-1–receptor scanning may offer a new ...
Elimination of C/EBPα through the ubiquitin-proteasome system promotes the development of liver cancer in mice
Authors: Guo-Li Wang, Xiurong Shi, Simon Haefliger, Jingling Jin, Angela Major, Polina Iakova, Milton Finegold, Nikolai A. Timchenko
Journal: Journal of Clinical Investigation (2010)

Despite significant advancements in our understanding of cancer development, the molecular mechanisms that underlie the formation of liver cancer remain largely unknown. C/EBPalpha is a transcription factor that regulates liver quiescence. Phosphorylation of C/EBPalpha at serine 193 (S193-ph) is upregulated in older mice and is thought to contribute to age-associated liver dysfunction. Because development of liver tumors is associated with increasing age, we investigated the role of S193-ph in the development of liver cancer using knockin mice expressing a phospho-mimetic aspartic acid residue in place of serine at position 193 (S193D) of C/EBPalpha. The S193D isoform of C/EBPalpha was able to completely inhibit liver proliferation in vivo after partial hepatectomy. However, treatment of these mice with diethylnitrosamine/phenobarbital (DEN/PB), which induces formation of liver cancer, actually resulted in earlier development of liver tumors. DEN/PB treatment was associated with specific degradation of both the S193-ph and S193D isoforms of C/EBPalpha through activation of the ubiquitinproteasome system (UPS). The mechanism of UPS-mediated elimination of C/EBPalpha during carcinogenesis involved elevated levels of gankyrin, a protein that was found to interact with the S193-ph isoform of C/EBPalpha and target it for UPS-mediated degradation. This study identifies a molecular mechanism that supports the development of liver cancer in older mice and potential therapeutic targets for the prevention of liver cancer.
Quinine‐induced immune thrombocytopenia with hemolytic uremic syndrome: Clinical and serological findings in nine patients and review of literature
Authors: Jerome L. Gottschall, Betsy Neahring, Janice G. McFarland, Guo‐Guang Wu, Lee Ann Weitekamp, Richard H. Aster
Journal: American Journal of Hematology (1994)

Abstract Quinine‐induced immune thrombocytopenia with hemolytic uremic syndrome (HUS) is a recently defined clinical entity. In this paper we have attempted to characterize the natural history and laboratory abnormalities typical of quinine‐induced immune thrombocytopenia associated with hemolytic uremic syndrome in nine patients experiencing ten episodes of the disease. In addition, review of other reported cases of probable quinine‐induced HUS is presented. The disease was characterized by the onset of chills, diapheresis, nausea and vomiting, abdominal pain, decreased urine output, and petechiae following quinine exposure. All patients experience significant anemia, severe thrombocytopenia, increased lactate dehydrogenase, elevated serum creatinine, and oliguria. Quinine‐dependent platelet‐reactive antibodies were identified in eight of nine using flow cytometry. Unexpectedly, drug‐dependent antibodies reactive with red cells and granulocytes were identified in four and eight patients, respectively. All patients were treated with plasma exchange (range 1–12 procedures), and seven required hemodialysis. All survive without residual abnormality. Our experience with nine patients with quinine‐induced HUS and the nine additional cases reported by others and reviewed in this paper establishes this condition as a distinct clinical entity. Adult patients presenting with HUS should routinely be asked about exposure to quinine in the form of medication or beverages. The mechanism by which quinine‐dependent antibodies produce renal failure is uncertain, but preliminary studies (described elsewhere) suggest that drug‐induced antibodies reactive with endothelial cells and possibly margination of granulocytes in renal glomeruli may be responsible for this complication. The prognosis in quinine‐induced HUS is better than in other forms of adult HUS. © 1994 Wiley‐Liss, Inc.
Haemolytic Disease and Congenital Syphilis in Siblings
Authors: M. N. McFarlane
Journal: BMJ (1945)

<h3>Aim</h3> One of the biggest challenges in paediatrics is helping young people with chronic conditions develop increasing independence as they grow up. An important barrier to this is reliance on parents to accompany young people to hospital appointments. We aimed to facilitate young people’s independence and prepare them for transition to adult services by running a pilot nurse-led clinic at a school. <h3>Methods</h3> We selected a secondary school where our team was responsible for multiple patients with type 1 diabetes. We scheduled onsite clinics throughout the year where young people could see a diabetes clinical nurse specialist either alone or with a friend in attendance. This replaced two of their four annual appointments. The school nurse was present for clinicians to highlight issues to the school. Following the school clinic, young people filled out a four-question survey. A junior doctor interviewed clinical staff for further qualitative feedback. <h3>Results</h3> All young people seen during the first clinic agreed that they felt more able to discuss sensitive issues and more confident to see a nurse or doctor on their own. They agreed that other students in their school understood their diabetes better. One student provided the following written feedback ‘<i>I liked today’s appointment because it was more free since my mum wasn’t here’</i>. Nurses running the clinic found it easier to discuss issues such as drugs, alcohol and sexual health without parents present. They reported young people engaged better with decisions surrounding diabetes management. Issues identified included difficulties scheduling around the school day and physical space available. The school clinic will run for the duration of 2018–2019 with further results expected. <h3>Conclusions</h3> Our experience supports school clinics as a tool for improving patient experience in children with type 1 diabetes. School clinics address several issues with the current model of care. They minimise time spent away from education, facilitate discussion of topics young people may not disclose around their parents and permit greater peer and school involvement. Importantly, they build young people’s confidence to see health professionals alone, which prepares them for adult services.
Correlation of Serum Lipids with Diabetes Control in Sulfonylurea-treated Diabetic Patients
Authors: Risto K Huupponen, Jorma S Viikari, Heikki Saarimaa
Journal: Diabetes Care (1984)

The relationships between fasting blood glucose, glycosylated hemoglobin A1, and several lipid parameters were studied in 67 non-insulin-dependent diabetic patients (19 men, 48 women) being treated with tolbutamide, chlorpropamide, or glibenclamide. All patients were over 60 yr of age with a mean age of 76.4 +/- 6.7 yr (+/- SD). There were positive associations between fasting blood glucose and serum cholesterol, LDL cholesterol, and serum triglycerides. A strong association between total cholesterol and triglycerides was also evident. Diabetes control and HDL cholesterol did not correlate with each other. A weak inverse correlation existed between fasting blood glucose and the HDL cholesterol/total cholesterol ratio. HDL cholesterol concentrations were low in the diet- and drug-treated diabetic patients. No deleterious sulfonylurea effects on cholesterol, LDL cholesterol, and triglyceride concentrations or HDL cholesterol/total cholesterol ratio were noted.
β-Endorphin levels lower in arthritis patients
Authors: Jaan Kangilaski
Journal: JAMA (1981)

One possible explanation of chronic pain accompanying various arthritic conditions is that the patient's body has lost part of the normal ability to produce endorphins. Charles W. Denko, MD, PhD, bases this hypothesis on a comparison of serum β-endorphin levels in normal persons and in patients with rheumatic disorders ranging from juvenile and adult rheumatoid arthritis to gout, pseudogout, and psoriatic arthritis. Virtually all of the patients had lower levels of endorphin, as determined by radioimmunoassay. Denko, clinical professor of medicine at Case Western Reserve University School of Medicine, Cleveland, described his findings in an interview and in a poster session at the recent Boston meeting of the American Rheumatism Association. "Pain may be a type of stress that causes the body to produce endorphins," he said. "People with arthritis are notoriously poor biochemical factories... So [they may have] a generalized metabolic deficiency that is a result of the disease
Molecular cytogenetic analysis of monosomy 7 in pediatric patients with myelodysplastic syndrome
Authors: K.J. Harrison, B. Massing, C. McKenna, D.K. Kalousek
Journal: American Journal of Hematology (1995)

Abstract Monosomy 7 is a non‐random cytogenetic abnormality that is frequently associated with myelodysplastic syndromes (MDS). Twenty‐four bone marrow samples from five pediatric patients with MDS were analysed using both traditional and Interphase cytogenetic analysis. The majority of the metaphases were monosomic for chromosome 7 while interphase cytogenetic analysis consistently detected a disomic cell population in nondividing cell populations. This suggests that the monosomy 7 cells have a distinct proliferative advantage compared to the disomic cell population. The results demonstrate that interphase cytogenetic analysis provides important cytogenetic information about non‐dividing cell subpopulations, enhancing our understanding of the cell dynamics of normal and monosomy 7 cells in MDS.
Pitfalls of statistical hypothesis testing: multiple testing
Authors: P. Sedgwick
Journal: BMJ (2014)

The effectiveness of a home based intervention on children’s body mass index (BMI) at age 2 years was investigated. A randomised controlled superiority trial was used. The intervention consisted of eight home visits from specially trained community nurses in the first 24 months after birth. The aim of the intervention was to improve the health and wellbeing of parents and children. The intervention was in addition to the usual childhood nursing service from community health service nurses. The control group received the usual childhood nursing service alone. Participants were first time mothers and their infants.1

The primary outcome measures were children’s anthropometric measures, including BMI, weight, and length, at age 2 years. Secondary outcomes comprised eight measures of dietary behaviour and four measures of physical activity and television watching for the child at age 2 years. These included eating habits (intake of fruit and vegetables, consumption of chips and snacks), having a meal in front of the TV, time spent watching TV, and active play time. Secondary outcomes also included seven measures of dietary behaviour, time spent watching TV, and physical activity for the mother 24 months after giving birth.

It was reported that mean BMI at age 2 years was significantly lower in the intervention group than in the control group (P=0.04). At 24 months after birth, dietary behaviours and TV watching were significantly different for children in the intervention group compared with the control group. Children in the intervention group ate more vegetables (P=0.03), whereas using food as a reward (P=0.03), TV being on during mealtimes (P=0.02), eating dinner in front of the TV (P=0.01), and watching TV for more …