Insulin Therapy in Diabetic Ketoacidosis
Authors: JOSEPH M. CONNORS
Journal: Annals of Internal Medicine (1977)

Comments1 January 1977Insulin Therapy in Diabetic KetoacidosisJOSEPH M. CONNORS, M.D.JOSEPH M. CONNORS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-1-109_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: To prepare for a recent housestaff conference I had to review the subject of insulin therapy in the treatment of diabetic ketoacidosis. I am concerned that the comparison between high-dose bolus insulin and low-dose intramuscular insulin made by Kitabchi and associates (1) does not justify their conclusion that "low dose intramuscular insulin therapy is simple and as effective as high dose therapy in the treatment of diabetic ketoacidosis without the risk of hypoglycemia and with a diminished incidence of hypokalemia."The data presented by the authors showed that there was no significant difference between the two regimens...References1. KITABCHI A, AYYAGARI V, and GUERRA S: The efficacy of low dose versus conventional therapy of insulin for treatment of diabetic ketoacidosis. Ann Intern Med 84:633-638, 1976 LinkGoogle Scholar2. FELIG P: Diabetic ketoacidosis. N Engl J Med 290:1360-1364, 1974 CrossrefMedlineGoogle Scholar3. SOLER N, FITZGERALD M, and WRIGHT A: Comparative study of different insulin regimens in management of diabetic ketoacidosis. Lancet 2:1221-1224, 1975 CrossrefMedlineGoogle Scholar4. FELIG P: Insulin: rates and routes of delivery. N Engl J Med 291:1031-1032, 1974 CrossrefMedlineGoogle Scholar5. MADISON L: LOW dose insulin: a plea for caution. N Engl J Med 294:393-394, 1976 CrossrefMedlineGoogle Scholar1. KITABCHI A, AYYAGARI V, and GUERRA S: The efficacy of low dose versus conventional therapy of insulin for treatment of diabetic ketoacidosis. Ann Intern Med 84:633-638, 1976 LinkGoogle Scholar2. SOLER N, FITZGERALD M, and WRIGHT A: Comparative study of different insulin regimens in management of diabetic ketoacidosis. Lancet 2:1221-1224, 1975 CrossrefMedlineGoogle Scholar3. FELIG P: Insulin: rates and routes of delivery. N Engl J Med 291:1031-1032, 1974 CrossrefMedlineGoogle Scholar4. MADISON L: LOW dose insulin: a plea for caution. N Engl J Med 294:393-394, 1976 CrossrefMedlineGoogle Scholar5. ARIEFF A: Kidney, water and electrolyte metabolism in diabetes mellitus, in The kidney, edited by Brenner BM, Rector FC, Philadelphia, W. B. Saunders Co., 1976, pp. 1257-1296 Google Scholar6. ALBERTI K: Comparison of different insulin regimens in diabetic ketoacidosis. Lancet 1:83-84, 1976 CrossrefGoogle Scholar7. SHAHSHAHANI M, GUERRA S, and KITABCHI A: Comparison of the absorption of insulin by intramuscular (IM), subcutaneous (SC) and intravenous (IV) routes in obese and lean non-ketotic diabetic patients. 1976, in press Google Scholar8. FISHER J, KITABCHI A, and SHAHSHAHANI M: Comparison of low-dose intramuscular (I.M), intravenous (I.V.) and subcutaneous (S. Q.) insulin therapy in diabetic ketoacidosis (DKA) (abstract). Clin Res 24:580A, 1976 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH M. CONNORS, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1977Volume 86, Issue 1Page: 109-111KeywordsHypoglycemiaInsulin ePublished: 1 December 2008 Issue Published: 1 January 1977 PDF downloadLoading ...