tbuckley/cabot-search huggingface dataset:
Abstract 980: PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells.
Authors: Atish S. Patel, Amit Tiwari, Eduardo Chufan, Satyakam Singh, Kamlesh Sodani, Nagaraju Anreddy, Tanaji Talele, Suresh Ambudkar, Ralph Stephani, Zhe-Sheng Chen
Journal: Cancer Research (2013)

Abstract Multidrug resistance (MDR) through overexpression of ATP-binding cassette (ABC) transporters has long evaded chemotherapy in cancer patients. Specific tyrosine kinase inhibitors (TKIs) were recently reported to modulate these ABC transporters, leading to an increase in the intracellular concentration of their substrate drugs. Here, we report for the first time, PD173074 an inhibitor of the fibroblast growth factor receptor (FGFR), to selectively inhibit ABC subfamily B member 1 (ABCB1/P-glycoprotein) transporter. PD173074 significantly sensitized both ABCB1 transfected and drug selected cell lines overexpressing this transporter to anticancer drugs colchicine, paclitaxel, and vincristine. This effect of PD173074 is specific, as no significant interaction was detected with other ABC transporters such as ABCC1, and ABCG2. The observed inhibition was primarily due to the decreased active efflux of [3H]-paclitaxel in ABCB1 overexpressing cells. However, no significant change in the ABCB1 expression was observed when ABCB1 overexpressing cells were exposed to 5 μM PD173074 for up to 3 days thereby suggesting its role in modulating the function of the transporter. In addition, PD173074 stimulated the ATPase activity of ABCB1 in a concentration-dependent manner, indicating a direct interaction with the transporter. Interestingly, PD173074 did not inhibit the photolabeling of ABCB1 with [125I]-Iodoarylazidoprazosin (IAAP) showing that it binds at a site different from that of IAAP in the drug-binding pocket. In conclusion, PD173074 could selectively reverse ABCB1-mediated MDR by directly blocking the efflux function of ABCB1. Citation Format: Atish S. Patel, Amit Tiwari, Eduardo Chufan, Satyakam Singh, Kamlesh Sodani, Nagaraju Anreddy, Tanaji Talele, Suresh Ambudkar, Ralph Stephani, Zhe-Sheng Chen. PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 980. doi:10.1158/1538-7445.AM2013-980
Joined-up working: introducing the best teams of the year
Authors: A. Gulland
Journal: BMJ (2012)

Anne Gulland reveals the shortlist for this year’s Working in Partnership award

Working with different agencies is not always easy, but it is vital for patients whose conditions do not fit into neat treatment silos. The shortlisted candidates for the 2012 Working in Partnership award are testaments to how team working across many different sectors can yield great outcomes.

The falls prevention service began with the premise that falls are not an inevitable part of ageing. The service screens all patients over the age of 60 at participating general practices and those identified at risk of a fall attend a review where they have a range of tests.

Steve Parry, consultant geriatrician at Newcastle Hospitals NHS Foundation Trust, believes the service is unique because it seeks out people at risk of a fall: it saw 2554 patients in its first two years.

“We have seen this astonishing number of people who never darken the doors of specialist services, people who have had falls or blackouts. Older people are stoic—they feel that falls are their lot in life,” he says.

The success has been striking—in 2010-11 rates of fracture of the neck of the femur rose in …
Unidirectional transfer in vivo of high-density lipoprotein cholesteryl esters to lower-density lipoproteins in the pig, an animal species without plasma cholesteryl ester transfer activity
Authors: Antonius H.M. Terpstra, Arthur F. Stucchi, Thomas L. Foxall, Glenn T. Shwaery, Donato B. Vespa, Robert J. Nicolosi
Journal: Metabolism (1993)
Final Exit: The Practicalities of Self Deliverance and Assisted Suicide for the Dying
Authors: Steven H. Miles
Journal: JAMA (1991)

<i>Final Exit</i>was the top-selling "selfhelp" book until a shortage stalled sales. It lent unusual prominence to a category of books normally occupied by titles about preparing tax returns, fixing sinks, or writing resumés. It provided a text to go with media coverage of the state of Washington's initiative to legalize voluntary active euthanasia. It led to dark humor about copies not being returned to the library. It struck a nerve, articulated a fear, and found a titillated market. This is an odd book to review for these pages. It neither examines the practice of medicine nor proposes ways to improve end-of-life medical care beyond empowering physicians to supervise suicide. It contradicts the position of the American Medical Association against euthanasia. Nevertheless, this is a noteworthy work of popular culture about the health care system. <i>Final Exit</i>reads like podium notes. It is a poorly edited mélange of anecdotes, first-person
VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet‐induced nonalcoholic steatohepatitis model in mice†
Authors: Arumugam Velayudham, Angela Dolganiuc, Michael Ellis, Jan Petrasek, Karen Kodys, Pranoti Mandrekar, Gyongyi Szabo
Journal: Hepatology (2008)

Nonalcoholic fatty liver disease (NAFLD) and its advanced stage, nonalcoholic steatohepatitis (NASH), are the most common causes of chronic liver disease in the United States. NASH features the metabolic syndrome, inflammation, and fibrosis. Probiotics exhibit immunoregulatory and anti-inflammatory activity. We tested the hypothesis that probiotic VSL#3 may ameliorate the methionine-choline-deficient (MCD) diet–induced mouse model of NASH. MCD diet resulted in NASH in C57BL/6 mice compared to methionine-choline-supplemented (MCS) diet feeding evidenced by liver steatosis, increased triglycerides, inflammatory cell accumulation, increased tumor necrosis factor α levels, and fibrosis. VSL#3 failed to prevent MCD-induced liver steatosis or inflammation. MCD diet, even in the presence of VSL#3, induced up-regulation of serum endotoxin and expression of the Toll-like receptor 4 signaling components, including CD14 and MD2, MyD88 adaptor, and nuclear factor κB activation. In contrast, VSL#3 treatment ameliorated MCD diet–induced liver fibrosis resulting in diminished accumulation of collagen and α-smooth muscle actin. We identified increased expression of liver peroxisome proliferator-activated receptors and decreased expression of procollagen and matrix metalloproteinases in mice fed MCD+VSL#3 compared to MCD diet alone. MCD diet triggered up-regulation of transforming growth factor beta (TGFβ), a known profibrotic agent. In the presence of VSL#3, the MCD diet–induced expression of TGFβ was maintained; however, the expression of Bambi, a TGFβ pseudoreceptor with negative regulatory function, was increased. In summary, our data indicate that VSL#3 modulates liver fibrosis but does not protect from inflammation and steatosis in NASH. The mechanisms of VSL#3-mediated protection from MCD diet–induced liver fibrosis likely include modulation of collagen expression and impaired TGFβ signaling. (HEPATOLOGY 2009.)
Myocardial Infarction After Carotid Stenting and Endarterectomy
Authors: Joseph L. Blackshear, Donald E. Cutlip, Gary S. Roubin, Michael D. Hill, Pierre P. Leimgruber, Richard J. Begg, David J. Cohen, John F. Eidt, Craig R. Narins, Ronald J. Prineas, Stephen P. Glasser, Jenifer H. Voeks, Thomas G. Brott
Journal: Circulation (2011)

The Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) found a higher risk of stroke after carotid artery stenting and a higher risk of myocardial infarction (MI) after carotid endarterectomy.Cardiac biomarkers and ECGs were performed before and 6 to 8 hours after either procedure and if there was clinical evidence of ischemia. In CREST, MI was defined as biomarker elevation plus either chest pain or ECG evidence of ischemia. An additional category of biomarker elevation with neither chest pain nor ECG abnormality was prespecified (biomarker+ only). Crude mortality and risk-adjusted mortality for MI and biomarker+ only were assessed during follow-up. Among 2502 patients, 14 MIs occurred in carotid artery stenting and 28 MIs in carotid endarterectomy (hazard ratio, 0.50; 95% confidence interval, 0.26 to 0.94; P=0.032) with a median biomarker ratio of 40 times the upper limit of normal. An additional 8 carotid artery stenting and 12 carotid endarterectomy patients had biomarker+ only (hazard ratio, 0.66; 95% confidence interval, 0.27 to 1.61; P=0.36), and their median biomarker ratio was 14 times the upper limit of normal. Compared with patients without biomarker elevation, mortality was higher over 4 years for those with MI (hazard ratio, 3.40; 95% confidence interval, 1.67 to 6.92) or biomarker+ only (hazard ratio, 3.57; 95% confidence interval, 1.46 to 8.68). After adjustment for baseline risk factors, both MI and biomarker+ only remained independently associated with increased mortality.In patients randomized to carotid endarterectomy versus carotid artery stenting, both MI and biomarker+ only were more common with carotid endarterectomy. Although the levels of biomarker elevation were modest, both events were independently associated with increased future mortality and remain an important consideration in choosing the mode of carotid revascularization or medical therapy.URL: http://www.ClinicalTrials.gov. Unique identifier: NCT00004732.
On Taking a Board Examination at the Age of 54
Authors: John J. McNamara
Journal: New England Journal of Medicine (1995)

According to my dictionary, epistemology is “the theory or science of the method and grounds of knowledge, especially with reference to its limits and validity.”1 How do we know something? How do we know whether someone else knows something? Do formal examinations assist us in answering this second question? Physicians have certainly taken enough of them.In October 1994, a subspecialty board examination in adolescent medicine was offered in the United States for the first time. As a formal area of medical practice, adolescent medicine dates from 1968, when the multidisciplinary Society for Adolescent Medicine was formed. For this first . . .
Autoimmune hyperthyroidism and thrombocytopenia developing in a patient with chronic lymphocytic leukemia
Authors: Alexander Haubenstock, Ralph Zalusky
Journal: American Journal of Hematology (1985)

Abstract A 56‐year‐old white man is described whose course of chronic lymphocytic leukemia (CLL) was complicated by the Occurrence of the autoimmune hyperthyroidism/ thrombocytopenia syndrome. The implications of this syndrome on the treatment of CLL are discussed.
Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung
Authors: IM Adcock, CR Brown, H Shirasaki, PJ Barnes
Journal: European Respiratory Journal (1994)

Glucocorticosteroids have a wide variety of effects which result in the long-term dampening of inflammatory responses. An important site of steroid action may be on the control of the activator protein-1 (AP-1) binding to deoxyribonucleic acid (DNA). AP-1 is a proinflammatory transcription factor composed of a heterodimer of Fos and Jun proto-oncogenes, which can be induced by phorbol esters and various cytokines. We have examined the hypothesis that dexamethasone may inhibit inflammation via an effect on AP-1 activation in human lung tissue. The effect of dexamethasone on the phorbol ester and cytokine activation of AP-1 and its monomers was examined in human lung tissue obtained from transplantation donors. AP-1 activation was measured by its ability to bind DNA, its localization in the nucleus by Western blotting, and the levels of fos and jun messenger ribonucleic acids (mRNAs) using Northern blotting. The phorbol ester, phorbol myristate acetate (PMA), caused a significant 2-3 fold increase in AP-1 DNA binding, which was sustained for 24 h and completely attenuated by co-incubation with dexamethasone. Dexamethasone alone caused a 40% decrease in AP-1 DNA binding. Dexamethasone modulated the expression of both c-jun and c-fos mRNA and produced long-term (24 h) 40% reduction in both mRNAs when compared to control tissues. PMA induced a rapid and prolonged increase in c-Fos and c-Jun nuclear localization, which was not attenuated by co-incubation with dexamethasone.(ABSTRACT TRUNCATED AT 250 WORDS)
Effect of Ultrasound on Chromosomes of Lymphocyte Cultures
Authors: U. Abdulla, D. Talbert, M. Lucas, M. Mullarkey
Journal: BMJ (1972)

In-vitro experiments have been undertaken to assess the effect of ultrasound at diagnostic and therapeutic levels on chromosomes of human lymphocyte cultures. The frequency used was about 2 MHz. The intensity was that of diagnostic level, 23 mW/cm<sup>2</sup>, which was increased stepwise to 3·5 W/cm<sup>2</sup>. The time of exposure varied from two to eight hours. No difference could be detected between the numbers of cells with aberrations in the insonated and control cultures, but aggregation of red cells was observed at high intensities.
Nitroaspirins and Morpholinosydnonimine but Not Aspirin Inhibit the Formation of Superoxide and the Expression of gp91 <sup>phox</sup> Induced by Endotoxin and Cytokines in Pig Pulmonary Artery Vascular Smooth Muscle Cells and Endothelial Cells
Authors: Saima Muzaffar, Nilima Shukla, Gianni Angelini, Jamie Y. Jeremy
Journal: Circulation (2004)

Although nonsteroidal antiinflammatory drugs (NSAIDs) are ineffective in treating acute respiratory distress syndrome (ARDS), inhalational NO has proved to be useful. NO-donating NSAIDs may therefore be more effective in treating ARDS than NSAIDs alone. Because oxidant stress is central to the pathophysiology of ARDS, the effect of nitroaspirins (NCX 4016, NCX 4040, and NCX 4050) compared with morpholinosydnonimine (SIN-1; an NO donor) and aspirin (ASA) on superoxide (O2*-) formation and gp91phox (an active catalytic subunit of NADPH oxidase) expression in pig pulmonary artery vascular smooth muscle cells (PAVSMCs) and endothelial cells (PAECs) was investigated.Cultured PAVSMCs and PAECs were incubated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1alpha (with or without NO-ASA, SIN-1, or ASA) for 16 hours, and O2*- release was measured by use of the reduction of ferricytochrome c. The expression of gp91(phox) was assessed by use of Western blotting. LPS, TNF-alpha, and IL-1alpha all stimulated the formation of O2*- and expression of gp91(phox) in both PAVSMCs and PAECs, an effect inhibited by NADPH oxidase inhibitors, diphenyleneiodonium, and apocynin. SIN-1, NCX 4016, and NCX 4050 but not ASA alone inhibited the formation of O2*- and expression of gp91(phox).LPS and cytokines promote the formation of O2*- in PAVSMCs and PAECs through an augmentation of NADPH oxidase activity, which in turn is prevented by NO. Thus, NO may play a protective role in preventing excess O2*- formation, but its negation by O2*- may augment the progress of ARDS. The inhibitory effect of nitroaspirins suggests that they may be therapeutically useful in treating ARDS through the suppression of NADPH oxidase upregulation and O2*- formation.
AR INDEX POST IMPLANT OF TWO DIFFERENT TRANSCATHETER AORTIC VALVES
Authors: Bernardo Lopez–Sanabria, Brian O'Neill, Sergio Andres Perez, Carlos Alfonso, Luis Miguel Benitez, Claudia Martinez, Pedro Martinez–Clark, Mauricio Cohen, Alan Heldman, William O'Neill, Antonio Dager, Eduardo De Marchena
Journal: Journal of the American College of Cardiology (2013)
Predictors of radiation failure after treatment of in-stent restenosis with gamma vascular brachytherapy: pooled analysis from GAMMA I, II, and SCRIPPS III studies
Authors: Thosaphol Limpijankit, A. Abizaid, R. Mehran, A.A. Lansky, G. Dangas, N. Kipshidze, G.W. Stone, M.B. Collins, J.W. Moses, M.B. Leon, P.S. Teirstein
Journal: Journal of the American College of Cardiology (2002)
Bronchodilator actions of xanthine derivatives administered by inhalation in asthma.
Authors: M J Cushley, S T Holgate
Journal: Thorax (1985)

The airway response to the inhalation of four alkyl xanthines was studied in 17 subjects with moderately severe asthma (mean FEV1 1.19 litres, 42% predicted). Theophylline (10 mg/ml), glycine theophyllinate (50 mg/ml), theophylline ethylenediamine (aminophylline 50 mg/ml), and diprophylline (125 mg/ml) were administered by nebulisation and the airway response was measured as percentage change from baseline of specific airway conductance (sGaw). All xanthine derivatives had an unpleasant taste and produced coughing at the onset of nebulisation. All four xanthines produced a significant increase in sGaw by comparison with saline placebo, with a maximum mean increase from baseline of 35% for theophylline, 40% for glycine theophyllinate, 60% for aminophylline, and 32% for diprophylline. Inhalation of 200 micrograms salbutamol from a metered dose inhaler produced an additional increase in sGaw of 149%. Thus alkyl substituted xanthines administered by inhalation to patients with asthma cause significant short lived bronchodilatation, but this effect is small compared with that of a conventional dose of an inhaled beta 2 adrenoceptor agonist.
But Buy It by the Case
Authors: Hugh A. Johnson
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of hepatitis B virus replication by adenine arabinoside monophosphate coupled to lactosaminated albumin. Efficacy and minimal active dose
Authors: M.R. Torrani Cerenzia, L. Fiume, C. Busi, A. Mattioli, G. Di Stefano, G.B. Gervasi, M.R. Brunetto, P. Piantino, G. Verme, F. Bonino
Journal: Journal of Hepatology (1994)
Prise en Charge des TIPMP: étude rétrospective de 47 malades
Authors: E Buc
Journal: Endoscopy (2008)

But: L'incidence des tumeurs intracanalaires papillaires et mucineuses du pancréas (TIPMP) augmente. La prise en charge chirurgicale précoce de ces tumeurs au potentiel dégénératif améliore le pronostic. Le but de cette étude était de rapporter les résultats de notre équipe et de dégager les facteurs de risques de dégénérescence.
Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice
Authors: Pascale V. Guillot, Oyebode Abass, J. H. Duncan Bassett, Sandra J. Shefelbine, George Bou-Gharios, Jerry Chan, Hitoshi Kurata, Graham R. Williams, Julia Polak, Nicholas M. Fisk
Journal: Blood (2007)
Physiology of the Gastrointestinal Tract
Authors: Ann Ouyang
Journal: JAMA (1988)

This is the second edition of a textbook that remains one of the most comprehensive books on the physiology of the gastrointestinal system. That the editors undertook this mammoth task only five years after the last edition is a tribute to all the contributors and reflects the rapid progress in research in this area. The editors aimed this work at investigators in the field and speculate that it may have use for clinicians and graduate students. Unless the clinicians are involved in research or the teaching of physiology, I suspect that the detail in which the topics are covered would not make this an attractive reference source for them. The first volume addresses regulation of gastrointestinal function and includes chapters on histochemistry, physiology of neuropeptides, neurophysiology of the enteric nervous system, endocrine cells and gastrointestinal hormones, prostanoids, and cell differentiation and growth in the small intestine. Detailed sections on motility
Postpartum haemorrhage and induction of labour.
Authors: P R Brinsden, A D Clark
Journal: BMJ (1979)

graft tissue, skin, to an abnormal culture atmosphere (45 ,' CO2 in air) for various periods (7-48 h).Normally-cultured skin grafts caused no lymphoid malignancy.Immunogenicity of exposed grafts as a result of modification of cell-surface proteins and production of "altered self" structures may be a factor in the subsequent appearance of lymphoma in these autologous hosts.In the animal models described above, malignant lymphoma develops as a late sequela of transplantations in the absence of exogenous immunosuppressants; chronic antigenic stimulation appears to be a possible common factor.Significantly, only lymphoid neoplasms developed despite the grafting of four different tissues-lymph node, mammary gland, skin, and bone marrow.Bone marrow is the only tissue that did not induce lymphoma in its recipients even following exposure to an unphysiological environment.This raises the question whether the T lymphocytes in the graft tissues are involved in the malignant processes in these animal models.
Mixing action and mitral inflow patterns in an isolated ventricle hydraulically operated
Authors: R. A. LLOYD, D. A. MCDONALD
Journal: Cardiovascular Research (1974)

A study of ventricular mixing was made and the findings related to indicator-dilution measurements of ventricular volume. Programmed actuation of an excised left ventricle provided lifelike instantaneous flow rates through the intact heart valves for the purpose of approximating the quality of mixing in a living ventricle. By monitoring indicator concentrations at 16 ventricular sites, mixing was found to be far from complete at end diastole.
Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation
Authors: Bryan Vander Lugt, Aly A Khan, Jason A Hackney, Smita Agrawal, Justin Lesch, Meijuan Zhou, Wyne P Lee, Summer Park, Min Xu, Jason DeVoss, Chauncey J Spooner, Cecile Chalouni, Lelia Delamarre, Ira Mellman, Harinder Singh
Journal: Nature Immunology (2013)