tbuckley/cabot-search huggingface dataset:
Abstract 1937: Development of microRNA-based prediction model of Trastuzumab treatment response for HER2-positive breast cancer using FFPE specimens.
Authors: Fumiaki Sato, Zhipeng Wang, Takayuki Ueno, Akira Myomoto, Satoko Takizawa, Feng Ling Pu, Norikazu Masuda, Yoshiki Mikami, Yoshiki Mikami, Kazuharu Shimizu, Shigehira Saji, Masakazu Toi
Journal: Cancer Research (2013)

Abstract [Background and Aim] Although Trastuzumab has been used for HER2(+) breast cancer, the treatment response of Trastuzumab therapy depends on unknown mechanisms among individual cases. In order to avoid unnecessary adverse events and to lighten financial burden, pre-treatment prediction of trastuzumab treatment response would be beneficial for patients. Thus, in this study, we develop a prediction algorithm using microRNA expression profile using formalin-fixed paraffin-embedded (FFPE) specimens of HER2(+) breast cancer. [Materials and Methods] Eighty-three breast cancer patients who underwent trastuzumab-chemo combined therapy before operations were enrolled with written informed consent. FFPE specimens of pre-treatment core needle biopsy samples were collected, and regions containing cancer and adjacent stromal cells were laser-microdissected. Total RNA samples extracted from the microdissected specimens were subjected for microRNA microarray (3D-Gene®, Toray, Japan) analysis. Among these 83 patients, 39 cases had pCR (definition: complete response in IDC regions regardless presence of DCIS without lymph node metastasis), and the other 44 cases did not. According to the pCR/non-pCR information, we develop a prediction model using 35 signature microRNAs by a SVM technique. Prediction accuracy assessed by Leave-one-out validation was AUROC=0.889. The 35 signature microRNAs for trastuzumab treatment response included 7 out of 8 let-7 family members and miR-125a-5p/b-5p, which were downregulated in pCR specimens. [Conclusion] microRNA profile could predict treatment response of trastuzumab-chemo combined therapy for HER2(+) breast cancer, and the developed prediction algorithm might be a useful tool for clinical decision making. Prediction Accuracy Outcome: non-pCR Outcome: pCR total Prediction: non-sensitive 35 6 41 Prediction: sensitive 9 33 42 total 44 39 83 Citation Format: Fumiaki Sato, Zhipeng Wang, Takayuki Ueno, Akira Myomoto, Satoko Takizawa, Feng Ling Pu, Norikazu Masuda, Yoshiki Mikami, Yoshiki Mikami, Kazuharu Shimizu, Shigehira Saji, Masakazu Toi. Development of microRNA-based prediction model of Trastuzumab treatment response for HER2-positive breast cancer using FFPE specimens. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1937. doi:10.1158/1538-7445.AM2013-1937
A memorable consultation
Authors: S. Farmer
Journal: BMJ (2008)

I always wanted to be a surgeon. I was once told that I didn’t have the “right personality” to succeed. I didn’t listen. Maybe I should have, maybe it was correct. For a start I’m female, and I would be the first to admit that I don’t have the “stereotypical surgical personality” … or so I thought.

Recently, I had one of those rare days that provoke serious thought and personal reflection. My consultant was on holiday, and so I was seeing the patients in the cancer …
Effect of Cortisone and ACTH on Blood Pressure of Hypotensive, Potassium-Deficient Rats
Authors: S. C. FREED, R. H. ROSENMAN, SHIRLEY ST. GEORGE, MALCOLM K. SMITH
Journal: Circulation Research (1954)

Potassium deficiency, induced in a series of rats by dietary deprivation, was associated with a depressor response. The administration of cortisone and, to a lesser extent, of corticotropin (ACTH), promptly elevated their lowered blood pressures. The possible participation of the adrenal cortex in the depressor response to potassium deficiency is discussed.
Transfection of cells from patients with leukocyte adhesion deficiency with an integrin beta subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function.
Authors: M L Hibbs, A J Wardlaw, S A Stacker, D C Anderson, A Lee, T M Roberts, T A Springer
Journal: Journal of Clinical Investigation (1990)

Leukocyte adhesion deficiency (LAD) is an inherited immunodeficiency disease that is characterized by the deficient expression of the leukocyte adhesion glycoproteins lymphocyte function-associated antigen-1 (LFA-1), Mac-1, and p150,95. This loss of expression is attributed to heterogeneous defects in the common beta subunit shared by these glycoproteins. Here we demonstrate that expression of the LFA-1 alpha beta heterodimer in EBV-transformed B lymphoblastoid cells from LAD patients can be recovered after transfection with the beta subunit cDNA contained in an EBV-based vector. Four patients with differing severities of LAD comprising three distinct classes of mutations were studied. Flow cytometry analysis of stably transfected patient cells revealed near normal levels of expression of both the alpha and beta chains of LFA-1, and immunoprecipitation studies confirmed that fully processed alpha and beta chains were being expressed at the cell surface. In addition, Northern analysis of mRNA expression also demonstrated that the transfected LAD patient cells were expressing high quantities of exogenous beta subunit mRNA. Functional studies such as homotypic adhesion and adhesion to a purified counterreceptor for LFA-1, intracellular adhesion molecule-1, demonstrated that LFA-1 function had been restored in the stably transfected LAD patient cell lines. These studies unequivocally show that the defect in cells from patients with LAD is in the leukocyte integrin beta subunit.
Interplay between environmental factors, articular involvement, and HLA-B27 in patients with psoriatic arthritis.
Authors: R Scarpa, A Del Puente, C di Girolamo, G della Valle, E Lubrano, P Oriente
Journal: Annals of the Rheumatic Diseases (1992)

Medical records of 138 patients with psoriatic arthritis and 138 with rheumatoid arthritis were reviewed for the occurrence of an environmental factor triggering arthritis. Twelve (9%) of the patients with psoriatic arthritis had had an acute disorder immediately preceding onset of arthritis (an operation in four cases, articular trauma in three, abortion in two, myocardial infarction, thrombophlebitis, and phosphoric ester intoxication in one case each). Peripheral arthritis occurred in all these patients. Among the rheumatoid patients, an acute event immediately preceding the onset of the disease was recorded in two cases (1%) only (chi 2 = 7.52; p = 0.006). No significant association was found in the arthritic patients between the incidence of acute events preceding arthritis onset and positivity of the HLA-B27 phenotype.
CHRONIC GLANDERS AND THE USE OF MALLEIN. Dr. A. Buschke
Authors: Frank H. Barendt
Journal: British Journal of Dermatology (1896)

CASES of glandem occurring in man are not frequent, judging from the literature of the subject.Besnier has recorded two.Hallopeau and Jeanselme one, and E. Neisser one.In these cases the nasal mucosa was the starting-point of the infection, and the course of the disease was very chronic, other lesions-ulcers, abscesses, periostitie-appearing in different regions of the body.Acute equinia may be confounded with enteric fever; it is characterized by infection of the mucosie, skin, internal viscera, especially the lungs, and, as a rule, ends &tally.Chronio glnnders is often diagnosed and treated as syphilis before its nature is
Book Review Neuromuscular Disorders of Infancy, Childhood, and Adolescence: A Clinician's Approach Edited by H. Royden Jones, Jr., Darryl C. De Vivo, and Basil T. Darras. 1323 pp., illustrated. Philadelphia, Butterworth–Heinemann, 2003. $285. 0-7506-7190-4
Authors: Marinos C. Dalakas
Journal: New England Journal of Medicine (2003)
A Persistent Brow Presentation
Authors: G. H. H. Booth
Journal: BMJ (1943)

BRkTISHQuick healing was also obtained with sulphathiazole in ecthyma and early infective dermatitis, but results were dis- appointing in infectious eczematoid dermatitis, acne vulgaris, and sycosis.We must express our indebtedness to Dr. Robert Forgan, medical consultant, Pharmaceutical Specialities (May and Baker) Ltd., for his kindness in
The Mechanical Basis of Respiration: An Approach to Respiratory Pathophysiology
Authors: Elihu A. Channin
Journal: JAMA (1970)

The scope of topics covered in the 14 chapters reflects the author's broad understanding of cardiopulmonary physiology and pathophysiology. These chapters include "Ventilation," "Mechanical Properties of the Respiratory System," "Pulmonary Circulation," "Chemical and Reflex Regulation of Respiration," and "Respirators." The chapter on "Blood Gases and Acid-Base Balance" is very well written. It is easily understood and will be welcomed by those who have had difficulty with this area of respiratory physiology. The chapter on "The Effects of Environment and the Level of Activity" is an interesting collection of information. Other chapters such as "Diffusion" are neither enlightening nor useful. The section on "The Energy Cost of Breathing," seems unnecessarily detailed. In general, there seems to be a tendency to take either a too-simple or too-advanced approach to the subject material. It is, therefore, difficult to imagine the level of reader to whom the volume is directed. Several errors (such as
Changes in the plasma clearance and protein binding of carbenoxolone with age, and their possible relationship with adverse drug effects.
Authors: M J Hayes, M Sprackling, M J Langman
Journal: Gut (1977)

Comparison by equilibrium dialysis of plasma protein binding sites for carbenoxolone in people under 40 years of age and in people over 65 years of age showed that the number of binding sites was reduced in the elderly and that this fall was associated with a reduction in plasma albumin levels.Although carbenoxolone has some aldosterone-like effects, these properties could not be shown to be due to displacement of aldosterone from its protein binding sites by competitive protein binding of carbenoxolone.Single doses of carbenoxolone were found to be removed con- siderably more slowly from the plasma of elderly individuals than from the young.The results of these three series of experiments suggest that the side-effects of carbenoxolone in the elderly may in part be caused by reduced protein binding, leaving more free drug in the active unbound form, and in part by reduced hepatic clearance mechanisms.
B-Fahf-2 Pretreatment Reduces OIT Adverse Reactions and Improves Outcomes In a Murine Model Of Multiple Nut Allergy
Authors: Xiu-Min Li, Ying Song, Changda Liu, Ilan Goldberg, Hugh A. Sampson, Kamal D. Srivastava
Journal: Journal of Allergy and Clinical Immunology (2014)
Mediator release assay for assessment of biological potency of German cockroach allergen extracts
Authors: Anna H. Nowak-Wegrzyn, Ramon Bencharitiwong, John Schwarz, Gloria David, Peyton Eggleston, Peter J. Gergen, Andrew H. Liu, Jacqueline A. Pongracic, Sampson Sarpong, Hugh A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2009)
Long Lasting Response to the Multikinase Inhibitor Bay 43-9006 (Sorafenib) in a Heavily Pretreated Metastatic Thymic Carcinoma
Authors: Giancarlo Bisagni, Giulio Rossi, Alberto Cavazza, Giuliana Sartori, Giorgio Gardini, Corrado Boni
Journal: Journal of Thoracic Oncology (2009)
THE IMPACT OF REDUCED 80 KVP TUBE VOLTAGE ON CORONARY CT ANGIOGRAPHY BY CT PLATFORM: RESULTS FROM A PROSPECTIVE, MULTICENTER, MULTIVENDOR RANDOMIZED TRIAL
Authors: Troy LaBounty, Jonathon Leipsic, Rohan Poulter, David Wood, Brett Heilbron, Monvadi B. Srichai, Carolyn Taylor, Mark Johnson, G.B. John Mancini, John Mayo, Allison Dunning, Fay Y. Lin, Millie Gomez, Jonathan W. Weinsaft, James K. Min
Journal: Journal of the American College of Cardiology (2011)
Health department still sees itself as "HQ of the hospital system," says former regulator
Authors: N. Timmins
Journal: BMJ (2010)

The former health secretary Alan Milburn’s powerful vision of a health department that championed the interests of patients and set priorities and national care standards but let hospitals in England get on with the job of running themselves remains a long way from being fulfilled, warns Bill Moyes, the former head of Monitor, the regulator of NHS foundation trusts. 

And, reflecting on his six years in the job, Mr Moyes, who stood down as chairman at the end of January, said he was pessimistic that foundation trusts’ freedoms would survive the forthcoming squeeze on public spending.

With almost half of all acute hospitals still not foundation trusts, a key opportunity to use the application process “to create a …
Viral Clostridial Light Chain Gene-based Control of Penicillin-induced Neocortical Seizures
Authors: Jun Yang, Qingshan Teng, Thais Federici, Imad Najm, Stephan Chabardes, Michael Moffitt, Andreas Alexopoulos, Jonathan Riley, Nicholas M Boulis
Journal: Molecular Therapy (2007)

Restraining excitatory neurotransmission within a seizure focus provides a nondestructive treatment strategy for intractable neocortical epilepsy. Clostridial toxin light chain (LC) inhibits synaptic transmission by digesting a critical vesicle-docking protein, synaptobrevin, without directly altering neuronal health. This study tests the treatment efficacy of adenoviral vector delivered LC (AdLC) on a model of seizures in rats induced by motor cortex penicillin (PCN) injection. LC expression significantly reduced electroencephalogram (EEG) frequency, amplitude, duration, and latency compared to control groups injected with either an adenoviral vector bearing green fluorescent protein (AdGFP) or phosphate buffered solution (PBS). Correspondingly, LC gene expression improved behavioral manifestations including seizure severity and latency. There was no statistical difference in motor function before and after vector administration between treatment and control groups. Histological analysis revealed spatially discrete LC expression with corresponding synaptobrevin depletion in the cortex surrounding the injection site. Thus, vector-mediated LC gene delivery is capable of improving both the EEG and behavioral manifestations of PCN-induced focal neocortical seizures through synaptobrevin depletion. Restraining excitatory neurotransmission within a seizure focus provides a nondestructive treatment strategy for intractable neocortical epilepsy. Clostridial toxin light chain (LC) inhibits synaptic transmission by digesting a critical vesicle-docking protein, synaptobrevin, without directly altering neuronal health. This study tests the treatment efficacy of adenoviral vector delivered LC (AdLC) on a model of seizures in rats induced by motor cortex penicillin (PCN) injection. LC expression significantly reduced electroencephalogram (EEG) frequency, amplitude, duration, and latency compared to control groups injected with either an adenoviral vector bearing green fluorescent protein (AdGFP) or phosphate buffered solution (PBS). Correspondingly, LC gene expression improved behavioral manifestations including seizure severity and latency. There was no statistical difference in motor function before and after vector administration between treatment and control groups. Histological analysis revealed spatially discrete LC expression with corresponding synaptobrevin depletion in the cortex surrounding the injection site. Thus, vector-mediated LC gene delivery is capable of improving both the EEG and behavioral manifestations of PCN-induced focal neocortical seizures through synaptobrevin depletion.
Medium term complications of endoscopic biliary sphincterotomy.
Authors: P A Winstanley, W R Ellis, I Hamilton, D J Lintott, A T Axon
Journal: Gut (1985)

One hundred and fifteen patients were reviewed between 18 months and five years after successful endoscopic biliary sphincterotomy for choledocholithiasis, postcholecystectomy in 93 (81%). Thirteen (14%) postcholecystectomy patients and 11 (50%, p less than 0.001) with intact gall bladders are dead (cause of death was ascertained in each case). Of the others, 43 were interviewed and 48 completed a postal questionnaire. Stone free common ducts had been documented in 69 (76%), presumed in 16 (17%), and not achieved in six (7%, excluded from analysis). None of the responding patients had developed serious new problems. Current symptoms of those with and without gall bladders and those with 'documented' and 'presumed' duct clearance are similar. In no case has an episode of cholangitis since sphincterotomy been confirmed and only one patient has had documented recurrent duct stones. Continued incompetence of the sphincter was shown radiologically by the presence of bile duct gas in 14 (41%) of 32 patients. These results suggest that medium term complications of endoscopic sphincterotomy are unusual.
The correlation between surface microscopy and dermal histology in tetradecane-induced comedones in rabbit ear skin
Authors: K. Motoyoshi
Journal: British Journal of Dermatology (1983)

Three concentrations of tetradecane and liquid paraffin were applied daily for 4 weeks to the external ear skin of rabbits, and the average diameter of the follicular lesions was measured under the Leitz MZ surface microscope. These observations showed that the increase in the size of follicular lesions with tetradecane was dose-dependent and the maximum diameter was reached on the 14th day. Serial biopsies were also taken for routine histology, and undiluted tetradecane was shown to produce follicular hyperkeratosis, microcomedones, closed comedones and open comedones. A good correlation was obtained between the surface observations and the histological findings. The surface microscope provides a simple and convenient in vivo method for evaluating comedo formation.
Urea Synthesis After Protein Feeding Reflects Hepatic Mass in Rats† ‡
Authors: Thomas G. Brewer, William R. Berry, John W. Harmon, Strothers H. Walker, Michael A. Dunn
Journal: Hepatology (1984)

Urea synthesis is an exclusive biosynthetic function of the liver. Since the exact relationship between urea synthesis in vivo and functional liver mass remains unclear, we established an animal model using oral protein loading and measurement of resultant urea synthesis in rats. We studied rats subjected to sham operation, 40% hepatectomy, 66% hepatectomy, portacaval shunt and CC1 4 -induced cirrhosis. Urea synthesis was calculated as the sum of urinary urea excretion and accumulation of urea in body water during the 6-hr period after oral administration of a casein protein load equivalent to 20 gm per kg body weight. Peak urea synthesis rate in the sham-operated group of rats was 142 ± 11 μmoles per hr per gm wet liver weight (mean ± 1 S.D.), 473 ± 34 μmoles per hr per gm liver protein and 80 ± 5 μmoles per hr per mg liver DNA. This rate closely matched those of the other groups for each type of liver mass measurement. Marked reduction (p &lt; 0.01) of urea synthesis on a DNA basis was noted only in the CCl 4 -cirrhotic livers, related to the significantly higher (p &lt; 0.01) DNA content of the cirrhotic livers. Similarly, increased (p &lt; 0.05) liver protein content of the sham-operated rats when compared with the other groups was reflected in slightly lower urea synthesis rates expressed on the basis of liver protein (p &lt; 0.05) when compared to that of all other groups. The slopes of the trend lines which define the relationship of urea synthesis rates in each group to total liver mass (liver weight, protein content and DNA content) were not significantly different. We conclude that urea synthesis rates after oral administration of a protein load reflect liver mass in terms of wet weight, liver protein content and liver DNA content. This relationship remains valid in the presence of changes in liver parenchymal mass, portacaval shunting and CC1 4 -cirrhosis.
Topical vitamin B12-a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial
Authors: M. Stucker, C. Pieck, C. Stoerb, R. Niedner, J. Hartung, P. Altmeyer
Journal: British Journal of Dermatology (2004)

Background Vitamin B12 is an effective scavenger of nitric oxide (NO). As the experimental application of a NO synthase inhibitor, Nω‐nitro‐l‐arginine, led to a clear decrease in pruritus and erythema in atopic dermatitis, it would be reasonable to assume a comparable effect of vitamin B12. Objectives The efficacy and tolerability of a new vitamin B12 cream as a possible alternative to current therapies was examined. Methods A prospective, randomized and placebo‐controlled phase III multicentre trial, involving 49 patients was conducted. For the treatment duration of 8 weeks, each patient applied twice daily (in the morning and evening) the vitamin B12‐containing active preparation to the affected skin areas of one side of the body and the placebo preparation to the contralateral side according to the randomization scheme. Results On the body side treated with the vitamin B12 cream, the modified Six Area Six Sign Atopic Dermatitis score dropped to a significantly greater extent than on the placebo‐treated body side (for the investigational drug 55·34 ± 5·74 SEM, for placebo 28·87 ± 4·86 SEM, P < 0·001). At the conclusion of the study, the investigator and patients awarded mostly a 'good' or 'very good' rating to the active drug (58% and 59%, respectively) and a 'moderate' or 'poor' rating to the placebo (89% and 87%, respectively). Conclusions Topical vitamin B12 is a new therapeutic approach in atopic dermatitis. These results document a significant superiority of vitamin B12 cream in comparison with placebo with regard to the reduction of the extent and severity of atopic dermatitis. Furthermore, the treatment was very well tolerated and involved only very low safety risks for the patients.
Notes on Traumatic and Arterio-venous Aneurysm
Authors: F. L. A. Greaves
Journal: BMJ (1915)

X rays showe(i a metal fragment on the outer side of the chest wall, high up in the axilla, with eight other tiny fragments lying along the track of the larger piece.CASE v.-4 rterio-venouts Aneurysmz (Femoral).Struck by shrapnel bullet on outer side of the left thiglh on September 6th, 1915; not muich haemorrhage at the timiie.Admitted two days later with nearly cleani entrance wound just in front of the left great trochanter.The general condition was good, but he comp?lained of pain dlown the fronlt of the left thighl and leg-distribution of long saphenous nerve.A l)rOb)e introduced into the wound failed to reach the bullet.An-v-ray photographl showed a sh1rapnel bullet in the adlductor r'egionI.