The Gouty Toe-A Multifactorial Condition
Authors: DANIEL J. MCCARTY
Journal: Annals of Internal Medicine (1977)

Editorial1 February 1977The Gouty Toe-A Multifactorial ConditionDANIEL J. MCCARTY, M.D., F.A.C.P.DANIEL J. MCCARTY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-2-234 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOur understanding of the pathogenesis of gouty inflammation continues to evolve. Elsewhere in this issue (p. 230), Simkin lucidly outlines an hypothesis to account for the localization of sodium urate crystals in the first metatarsophalangeal (bunion) joint as opposed to other dependent small joints (1). He assumes a constant association of urate crystals and acute gout. This association has been widely accepted since it was first described by Hollander and me in these pages 15 years ago.In my own experience, phagocytosed urate crystals have almost always been found during the acute attack in the joint fluid, with the rare...References1. SIMKIN P: The pathogenesis of podagra. Ann Intern Med 86:000-000, 1977 LinkGoogle Scholar2. KATZ W and SCHUBERT M: The interaction of monosodium urate with connective tissue components. J Clin Invest 49:1783-1789, 1970 CrossrefMedlineGoogle Scholar3. MACLACHLAN M and RODNAN G: Effects of food, fast and alcohol on serum uric acid and acute attacks of gout. Am J Med 42:38-57, 1967 CrossrefMedlineGoogle Scholar4. BENNETT R, LEHR J, and MCCARTY D: Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure. Arthritis Rheum 19:93-97, 1976 CrossrefMedlineGoogle Scholar5. MCCARTY D and KOZIN F: An overview of cellular and molecular mechanisms in crystal-induced inflammation. Arthritis Rheum 18(suppl):757-764, 1975 CrossrefMedlineGoogle Scholar6. GARROD A: A Treatise on Gout and Rheumatic Gout (Rheumatoid Arthritis), 3rd ed. London, Longmans, Green & Co. Ltd., 1876 Google Scholar7. KATZ W: Deposition of urate crystals in gout. Altered connective tissue metabolism. Arthritis Rheum 18 (suppl):751-756, 1975 CrossrefMedlineGoogle Scholar8. MCCARTY D: Calcium pyrophosphate dihydrate crystal deposition disease—1975. Arthritis Rheum 19(suppl):275-285, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL J. MCCARTY, M.D., F.A.C.P.Affiliations: Department of Medicine Medical College of Wisconsin Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGout and HyperuricemiaPersistence of monosodium urate crystals and low-grade inflammation in the synovial fluid of patients with untreated goutCrystal Deposition in the Knee and Great Toe Joints of Asymptomatic Gout PatientsGelenkeAcute temporomandibular arthritis in a patient with bruxism and calcium pyrophosphate deposition diseaseExperimental modelsA hypothesis on the possible role of interferon in the initiation of acute gouty arthritis attackStudies on the nucleation of monsodium urate at 37°CAcute gouty bursitis: report of 15 cases.Urate Crystals in Asymptomatic Metatarsophalangeal JointsABRAHAM WEINBERGER, M.D., H. RALPH SCHUMACHER, M.D., CARLOS A. AGUDELO, M.D.Definitive Diagnosis of Gout by Identification of Urate Crystals in Asymptomatic Metatarsophalangeal JointsRole of Proteoglycans in the Development of Gouty ArthritisRole of Local Factors in the Precipitation of Urate CrystalsGout in The Bible and The TalmudFRED ROSNER, M.D., F.A.C.P. 1 February 1977Volume 86, Issue 2Page: 234-236KeywordsGoutInflammationPathogenesisUric acid ePublished: 1 December 2008 Issue Published: 1 February 1977 PDF downloadLoading ...