tbuckley/cabot-search huggingface dataset:
Interpreting phenotypic variation in plants
Authors: James S. Coleman, Kelly D.M. McConnaughay, David D. Ackerly
Journal: Trends in Ecology & Evolution (1994)

Plant ecologists and evolutionary biologists frequently examine patterns of phenotypic variation across variable environments or genetic identities. Too often, we ignore the fact that most phenotypic traits change throughout growth and development of individual plants, and that rates of growth and development are highly variable. Plants growing in different environments are likely to grow at different rates, and will be of different sizes and stages of development at a particular age. When we compare plants as a function of plant size or developmental stage, as well as a function of age, we broaden our understanding of phenotypic variation between plants.
Errors with Penicillin
Authors: PAUL GOLDFINGER
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 March 1975Errors with PenicillinPAUL GOLDFINGER, M.D.PAUL GOLDFINGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-3-426_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the September issue, Galpin and associates (Ann Intern Med 81:358-359, 1974) discussed the risks associated with the inadvertent intravenous use of aqueous procaine penicillin G.I should like to alert you to a potential source of error in this regard. A hospital patient was to receive crystalline penicillin G by the intravenous route. The pharmacy sent up Crysticillin⌖, which is the E. R. Squibb (New York, New York) brand of aqueous procaine penicillin G. Fortunately, the error was picked up.I suggest that the trade name of this product be changed.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL GOLDFINGER, M.D.Affiliations: 2 Mt. Prospect Avenue Dover, New Jersey 07801 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1975Volume 82, Issue 3Page: 426-426KeywordsPenicillin ePublished: 1 December 2008 Issue Published: 1 March 1975 PDF downloadLoading ...
Book Review Post-Viral Fatigue Syndrome Edited by Rachel Jenkins and James Mowbray. 463 pp. New York, John Wiley, 1993. $137.50. 0-471-92846-1 Chronic Fatigue Syndrome Edited by David M. Dawson and Thomas D. Sabin. 218 pp., illustrated. Boston, Little, Brown, 1993. $65. 0-316-17748-2
Authors: Stephen E. Straus
Journal: New England Journal of Medicine (1994)
Prolonged carbon dioxide insufflation under general anesthesia for endoscopic submucosal dissection
Authors: T. Suzuki, H. Minami, T. Komatsu, R. Masusda, Y. Kobayashi, A. Sakamoto, Y. Sato, H. Inoue, K. Serada
Journal: Endoscopy (2010)

Background and study aims: Carbon dioxide (CO2) insufflation for endoscopy has been reported to provide superior recovery and is expected to reduce the risk of serious complications, including air embolism and tension pneumothorax, whereas general anesthesia offers some advantages not found under intravenous sedation. Little is known about the effect of prolonged CO2 insufflation into gastrointestinal tracts on arterial CO2 tension (PaCO2). Here we introduce the use of general anesthesia with CO2 insufflation for esophagogastroduodenal endoscopic submucosal dissection (ESD).
Assessment and Management of Back Pain—Reply
Authors: John N. Mafi, Bruce E. Landon
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Bivalirudin reduced major bleeding and adverse events in patients with STEMI having PCI
Authors: Christopher W. Good
Journal: Annals of Internal Medicine (2008)

ACP Journal Club16 September 2008Bivalirudin reduced major bleeding and adverse events in patients with STEMI having PCIChristopher W. Good, DO, Peter B. Berger, MDChristopher W. Good, DOGeisinger Clinic, Danville, Pensylvania, USA (C.W.G., P.B.B.)Search for more papers by this author, Peter B. Berger, MDGeisinger Clinic, Danville, Pensylvania, USA (C.W.G., P.B.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-6-200809160-02011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationStone GW, Witzenbichler B, Guagliumi G, et al. Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med. 2008;358:2218-30. https://pubmed.ncbi.nlm.nih.gov/18499566Clinical Impact RatingsCardiology: References1 Lincoff AM, Bittl JA, Harrington RA, et al; REPLACE-2 Investigators. Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial. JAMA. 2003;289:853-63. [PMID: 12588269] Google Scholar2 Stone GW, McLaurin BT, Cox DA, et al; ACUITY Investigators. Bivalirudin for patients with acute coronary syndromes. N Engl J Med. 2006;355:2203-16. [PMID: 17124018] Google Scholar Author, Article, and Disclosure InformationAffiliations: Geisinger Clinic, Danville, Pensylvania, USA (C.W.G., P.B.B.)This article was published at Annals.org on 2 September 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 September 2008Volume 149, Issue 6Page: JC3-11KeywordsAnticoagulantsGlycoproteinsHemorrhageHeparinPercutaneous coronary interventionRevascularizationStent implantationThrombosis ePublished: 16 September 2008 Issue Published: 16 September 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Future of Psychiatry as Clinical Neuroscience
Authors: David A. Ross, Michael J. Travis, Melissa R. Arbuckle
Journal: JAMA Psychiatry (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Book: In arduis fidelis: Centenary History of The Royal Army Medical Corps 1898-1998
Authors: J. Pearn
Journal: BMJ (1998)

John S G Blair Scottish Academic Press, £25, pp 576 ISBN 0707 3076 94 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> One in eight of all doctors who graduate from the medical schools in countries that follow the British system will serve in uniform at some stage of their medical careers. Military medicine is an important part of the profession more generally, and all will be touched by it in the wars of the unknowable future. Insofar as history is a tool for decision makers of the present, In arduis fidelis joins the ranks of major texts that chronicle the evolution of this important institution, the Royal Army Medical Corps—important not only in the army and in medicine,but in society itself. The author, Dr (Colonel) John Blair is eminently suited to write this history. A senior surgeon in civilian life … [1]: F1/embed/inline-graphic-1.gif [2]: F1/embed/inline-graphic-2.gif [3]: F1/embed/inline-graphic-3.gif
Anti-RhD prophylaxis for RhD negative pregnant women
Authors: Z. Alfirevic, T. Callaghan
Journal: BMJ (2014)

A simple antenatal blood test can target treatment only to those with RhD positive babies

When the father’s red cells are RhD positive and the mother is RhD negative, fetal blood cells will have paternally derived RhD antigen foreign to the mother. If a sufficient volume of fetal RhD positive blood enters maternal circulation, the mother will be sensitised. She will develop anti-RhD IgG antibodies that could endanger her fetus. These antibodies can cross the placenta and cause immune destruction of fetal cells, leading to fetal anaemia, fetal hydrops, and even death in extreme cases. As a rule, maternal rhesus sensitisation occurs during delivery of the placenta, putting any subsequent pregnancy at risk, but sensitisation can also happen during pregnancy.

Births of affected babies are fortunately a thing of the past thanks in part to the development of effective prophylaxis against rhesus disease, which began in the 1960s when Ronald Finn, Cyril Clarke, and colleagues did a series of well controlled studies in which they gave anti-D immunoglobulin concentrate to Liverpool policemen known locally as the “pregnant dads.” They then showed that …
Daily Administration of Unilateral ECT
Authors: RICHARD ABRAMS
Journal: American Journal of Psychiatry (1967)

In comparing two groups of schizophrenic patients who received unilateral ECT to the nondominant hemisphere three and five times a week respectively, no statistically significant differences in scores on the Wechsler Memory Form I were observed after a series of 20 ECTs. In addition, the author and the nursing staff did not observe the presence of confusion, memory loss, dis orientation, or incontinence in any of the patients treated.
F-18 Fluorodeoxyglucose and F-18 Fluorothymidine Positron Emission Tomography/Computed Tomography Imaging in a Case of Neurosarcoidosis
Authors: Seok-Ki Kim, Hyung Jun Im, Woojun Kim, Tae-Sung Kim, Bin Hwangbo, Ho Jin Kim
Journal: Clinical Nuclear Medicine (2010)

F-18 fluorothymidine (FLT) PET/CT is considered more specific for malignancy than F-18 fluorodeoxyglucose (FDG) PET/CT. This case report presents F-18 FLT and F-18 FDG scans of a patient with neurosarcoidosis.We describe a 34-year-old man who presented with myelopathic symptoms and signs. The patient's evaluation included serological tests for systemic autoimmunity, CSF analysis, magnetic resonance imaging of the spinal cord and brain, abdominal CT, whole-body F-18 FDG and F-18 FLT PET/CT, and high-resolution chest CT. The patient finally underwent transbronchial mediastinal lymph node biopsy for definite diagnosis.The neurologic symptoms were relapsing and remitting. Magnetic resonance imaging demonstrated corresponding abnormal lesions in the spinal cord. Under a tentative diagnosis of multiple sclerosis, the patient was treated with beta-interferon, which showed no beneficial effect. Abdominal CT for evaluation of unexplained abdominal discomfort revealed abdominal lymphadenopathies. F-18 FDG PET/CT showed multiple symmetrical intense accumulations of F-18 FDG on mediastinal and abdominal lymph nodes, whereas only faint to mild F-18 FLT accumulations were observed. Biopsy of mediastinal lymph nodes indicated nontuberculous granulomatous disease. A final diagnosis of neurosarcoidosis was made, and his clinical symptoms and signs were markedly improved by immunosuppressive treatment.Multiple F-18 FDG-avid lymphadenopathies with mild F-18 FLT uptake can be characteristic findings of sarcoidosis. The combination of F-18 FDG and F-18 FLT PET/CT can be helpful in differentiating granulomatous inflammatory diseases such as neurosarcoidosis from malignancy and in localizing the most appropriate biopsy site of active sarcoidosis.
Fetal Macrosomia—Animal Models
Authors: Robert Schwartz, John Susa
Journal: Diabetes Care (1980)

Macrosomia is characteristic of the infant whose mother has undiagnosed diabetes mellitus during pregnancy or whose diabetes has been inadequately controlled. Animal models of diabetes have included effects of pancreatectomy or beta-cell destruction by chemical agents. Maternal effects have been variable as have been effects on the fetus. Recent studies by Van Assche indicate that chemically induced diabetes may have genetically transmitted effects through three generations in rats. End-organ effects of hyperinsulinemia have been produced in normal fetal rhesus monkeys without maternal hyperglycemia. In this model, macrosomia and selective organomegaly similar to changes observed in the human infant of the diabetic mother were produced. Hepatic enzyme activities concerned with lipogenesis were increased, while some of those controlling gluconeogenesis were decreased. The primary effects of insulin in utero appear to accelerate growth.
Office evaluation of hypertension. A statement for health professionals by a writing group of the Council for High Blood Pressure Research, American Heart Association.
Authors: R W Gifford, W Kirkendall, D T O'Connor, W Weidman
Journal: Circulation (1989)

The ultimate purpose of office evaluation of the hypertensive patient is to provide optimal management of blood pressure and associated risk factors. The workup includes a valid estimate of average blood pressure, including home blood pressure measurements, assessment of the degree of target organ damage, and identification of other risk factors, including family history. The history and physical examination should be directed to the principal target organs, including the optic fundi, central nervous system, heart, and kidneys. Laboratory evaluation should include urinalysis, ECG, and determinations of blood hemoglobin/hematocrit, creatinine, potassium, glucose, and cholesterol, including HDL fraction. This information will alert the physician to the possibility of curable forms of hypertension such as coarctation of the aorta, pheochromocytoma, primary aldosteronism, and renovascular hypertension. The office evaluation is also concerned with estimating prognosis and extent of organic damage, which is essential in planning management. The nurse or trained allied health professional should be used to the fullest possible extent both in evaluation and management of hypertensive patients.
West Nile Virus
Authors: Stephen M. Ostroff
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intellectual era ahead for medical computing
Authors: Charles Marwick
Journal: JAMA (1984)

The Division of Computer Research and Technology (DCRT), just 20 years old this year, pursues the dual roles of research and development, incorporating computers into the biomedical programs and administrative procedures at the NIH. It also supplies other federal agencies with biomedical and computing services. The NIH's raison d'être is biomedical research, and here the DCRT plays its most important service role, says Arnold W. Pratt, MD, the division's first and only director: "Researchers present us with a problem and we see how we can help them solve it. Also, if we see that there's a problem to tackle, we go ahead and set up a program, telling the institutes it's available and what it can do for them. "We work in close collaboration with the institutes on programs they sponsor. There's a unique combination of scientific intelligence here at DCRT that understands mathematics, statistics, engineering, and other elements of
FDA Panel Issues Mixed Decision on Quetiapine in Depression and Anxiety
Authors: Bridget M. Kuehn
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A RATIONAL METHOD OF RELIEVING ASPHYXIA IN THE NEW-BORN INFANT.
Authors: S. STRINGER
Journal: JAMA (1898)

I desire to call the attention of the medical profession to a method of relieving asphyxiated new-born infants which I do not think has been presented to their notice heretofore.  I do not claim for this method that it is novel, unique, etc., but that it is based entirely upon chemic and philosophic principles and, like many other facts in our profession, is the result of accidental discovery.  We know that in the asphyxiated infant, unless the blood becomes oxygenated very soon, the child must die; we know that from several causes the sensorium has become so deadened or blunted as not to respond to the irritation of the atmospheric air, the application of water or other methods of inducing respiration; yet fetal life still remains and would continue were it not that the placenta has become detached and thereby respiration or oxygenation of the blood, through the medium of
Role of Plasminogen System Components in Focal Cerebral Ischemic Infarction
Authors: N. Nagai, M. De Mol, H. R. Lijnen, P. Carmeliet, D. Collen
Journal: Circulation (1999)

The role of plasminogen system components in focal cerebral ischemic infarction (FCI) was studied in mice deficient in plasminogen (Plg-/-), in tissue or urokinase plasminogen activator (tPA-/- or uPA-/-), or in plasminogen activator inhibitor-1 or alpha2-antiplasmin (PAI-1(-/-) or alpha2-AP-/-).FCI was produced by ligation of the left middle cerebral artery and measured after 24 hours by planimetry of stained brain slices. In control (wild-type) mice, infarct size was 7.6+/-1.1 mm3 (mean+/-SEM), uPA-/- mice had similar infarcts (7.8+/-1.0 mm3, P=NS), tPA-/- mice smaller (2.6+/-0.80 mm3, P<0.0001), PAI-1(-/-) mice larger (16+/-0.52 mm3, P<0.0001), and Plg-/- mice larger (12+/-1.2 mm3, P=0.037) infarcts. alpha2-AP-/- mice had smaller infarcts (2. 2+/-1.1 mm3, P<0.0001 versus wild-type), which increased to 13+/-2.5 mm3 (P<0.005 versus alpha2-AP-/-) after intravenous injection of human alpha2-AP. Injection into alpha2-AP-/- mice of Fab fragments of affinospecific rabbit IgG against human alpha2-AP, after injection of 200 microg human alpha2-AP, reduced FCI from 11+/-1.5 to 5.1+/-1.1 mm3 (P=0.004).Plg system components affect FCI at 2 different levels: (1) reduction of tPA activity (tPA gene inactivation) reduces whereas its augmentation (PAI-1 gene inactivation) increases infarct size, and (2) reduction of Plg activity (Plg gene inactivation or alpha2-AP injection) increases whereas its augmentation (alpha2-AP gene inactivation or alpha2-AP neutralization) reduces infarct size. Inhibition of alpha2-AP may constitute a potential avenue to treatment of FCI.
Prognostic significance of blood coagulation tests in lung cancer
Authors: D. Ferrigno, G. Buccheri, I. Ricca
Journal: European Respiratory Journal (2001)

Previous studies have shown that activation of coagulation has an impact on the clinical course of lung cancer. This study was carried out to assess the potential prognostic significance of platelet count (P), prothrombin time (PT), partial thromboplastin time (PTT), anti-thrombin III (AT-III), fibrinogen (F), D-dimer (DD), factor II (F-II), factor VII (F-VII), factor X (F-X), protein C clotting (PCC), plasminogen (PL), and antiplasmin (AP) in 343 consecutive new lung cancer patients. A set of 32 anthropometric, clinical, physical, laboratory, radiological, and pathological variables was recorded prospectively for all patients. Patients were carefully followed-up, and their subsequent clinical course recorded. The most frequent abnormalities were of DD, F, and AT-III followed by F-VII, F-X, and F-II. Among the 12 clotting variables, the strongest relationships were those of F-II and F-X (Spearman rank (r s )=0.565), PT and F-VII (r s =0.562), F-VII and F-X (r s =0.514), PL and AP (r s =0.515), F and P (r s =0.490), AT-III and PCC (r s =0.476). Univariate analyses of survival showed that prolonged PT (p&lt;0.043), and abnormally elevated DD (p&lt;0.003), F (p&lt;0.031), and P (p&lt;0.047) were all associated with a poor prognosis. The multivariate model, however, did not confirm the prognostic significance of the coagulation factors. The results show subclinical activation of blood coagulation in lung cancer patients with early disease. In addition, clotting activation is confirmed as a predictor of survival, although not independently of other prognostic factors.