tbuckley/cabot-search huggingface dataset:
The Basophil Reaction in the Detection of Anaphylactic Hypersensitivity to Penicillin.
Authors: W. B. Shelley
Journal: Annals of Internal Medicine (1962)

s1 April 1962The Basophil Reaction in the Detection of Anaphylactic Hypersensitivity to Penicillin.W. B. Shelley, M.D., Ph.D., F.A.C.P.W. B. Shelley, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-690_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA new cyto-immune method for use in the detection of the immediate type hypersensitivity to penicillin and other drugs is outlined. This method is based on the observation that the basophilic leukocyte in man undergoes degranulation when exposed in vitro to specific antigens in appropriate concentrations. The usefulness and the limitations of the test are surveyed.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. (BS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 690-690KeywordsAntigensAttentionBasophilsDrugsHypersensitivityPenicillin Issue Published: 1 April 1962 PDF DownloadLoading ...
Young patient with Gorham's syndrome.
Authors: I. B. Wilkinson, W. J. Kinnear
Journal: Thorax (1996)

We were asked recently by our orthopaedic colleagues for advice on a young patient with Gorham's syndrome.He had the characteristic osteolytic lesions, predominantly affecting the vertebral column, and bilateral pleural effu- sions.Unable to recall this syndrome on the list of potential causes for a pleural effusion, we turned to the text books.With each edition the lists get longer -for example, Respiratory Medicine by Brewis et al' cites 38 possibilities
Ethical Dilemmas for House Staff Physicians-Reply
Authors: William Winkenwerder
Journal: JAMA (1986)

<h3>In Reply.—</h3> I agree strongly with the comments of Drs Forrow, Arnold, and Cassel and Ms Blank. There are major deficiencies in graduate medical training programs regarding ethical dimensions of clinical care, and the residency training period would be the best time to have an impact on physicians' behavior. However, there are obstacles in addressing this problem. Many attending physicians are not prepared to discuss, much less teach, ethical problems in patient care. Such activities are not rewarded. There is little consensus about how to teach approaches for dealing with complex ethical dilemmas. Residents already feel over-whelmed with their current load of educational demands. Nonetheless, efforts must be made, and I am gratified by the obvious interest of the American Board of Internal Medicine and others in seeking better ways to prepare physicians for ethical dimensions of clinical care. It can be done. I share Dr Light's belief that time
New York attacks raccoon rabies from the air
Authors: F. Charatan
Journal: BMJ (1995)

The largest vaccination programme against raccoon rabies in the United States started this month. Cornell University's College of Veterinary Medicine is cooperating with New York State in arranging an air drop of baits containing vaccinia-rabies glycoprotein around the St Lawrence River and Niagara County near the US-Canadian border.

The oral vaccine was recently approved by the US …
Sinus Arrest during Rem Sleep in Young Adults
Authors: Christian Guilleminault, Peter Pool, Jorge Motta, Anne M. Gillis
Journal: New England Journal of Medicine (1984)

Four apparently healthy young adults with vague chest symptoms during the day, two of whom had infrequent syncope while ambulatory at night, had periods of asystole up to nine seconds in duration occurring repeatedly during rapid-eye-movement (REM) sleep. Extensive evaluations, including electrophysiologic studies in two patients, were normal. It is therefore suggested that the underlying pathophysiology involved autonomic dysfunction. REM sleep-related sinus arrests such as these, which may occur in apparently healthy subjects but are undetected, may explain some cases of sudden, unexpected death during sleep. Polygraphic monitoring during sleep may be helpful in delineating the pathophysiology of the sleep-related arrhythmia in persons with daytime cardiac arrhythmias thought to be secondary to abnormal vagal tone. The possibility of nocturnal asystole should be considered in patients such as those described here.
EFFICACY OF ANTIVARIOLAR VACCINATION IN THE PHILIPPINES DURING 1921 AND 1922
Authors: REGINO G. PADUA
Journal: JAMA (1923)

Heiser and Leach,<sup>1</sup>in their article entitled "Vaccination in the Philippines Still Effective," presented a summarized study regarding the possible causation of the outbreak of smallpox in 1918, and of the casualties of the disease up to 1920. In the same article, some of the many difficulties encountered in the way of vaccination were pointed out. In the present paper I shall attempt to supplement what was said on the immunizing value of antivariolar vaccination, as observed in the last two years. For the purpose of this study, an analysis of all available statistics, on the morbidity and the mortality of smallpox and on the results of vaccination during 1921 and 1922, has been made. <h3>MORBIDITY AND MORTALITY RATES IN GENERAL</h3> In Manila, where there had been preformed every year higher proportions of successful vaccinations, smallpox completely disappeared in 1921 and 1922; the last five cases, with three deaths,
Skeletal Muscle Oxidative Capacity, Fiber Type, and Metabolites after Lung Transplantation
Authors: XIAO N. WANG, TREVOR J. WILLIAMS, MICHAEL J. McKENNA, JIA L. LI, STEVEN F. FRASER, ELEONORA A. SIDE, GREGORY I. SNELL, E. HAYDN WALTERS, MICHAEL F. CAREY
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Lung transplant (LTx) recipients have a low peak work rate, peak oxygen consumption (V O2peak), and early lactate threshold on incremental exercise. We hypothesized that LTx recipients have reduced oxidative function and altered fiber type proportion in peripheral skeletal muscle. Seven stable LTx recipients and seven age- and sex-matched control subjects were studied. Incremental exercise testing with arterialized venous sampling and a resting quadriceps femoris punch muscle biopsy were performed. Muscle specimens were analyzed for fiber type proportion, metabolites, oxidative and glycolytic enzyme activities, and mitochondrial ATP production rate (MAPR) using standard techniques. The results showed that mean V O2peak in LTx recipients was 52% of control subjects. Compared with the control subjects, LTx skeletal muscle exhibited: (1) a lower MAPR; (2) lower activity of the mitochondrial enzymes glutamate dehydrogenase (GDH), citrate synthase (CS), 2-oxogluterate dehydrogenase (OGDH), and 3-hydroxyacyl-CoA-dehydrogenase (HAD). There was no difference in the activities of anaerobic enzymes, except for higher phosphofructokinase activity; (3) a lower proportion of type I fibers; (4) a higher lactate and inosine monophosphate (IMP) content and a lower ATP content at rest indicating a high reliance on anaerobic metabolism. The reduced type I fiber proportion and severely reduced mitochondrial oxidative capacity may play an important role in exercise limitation after LTx.
Disassociation of Splenic Accumulation of Tc-99m MDP and Radiocolloid
Authors: RICHARD P. SPENCER, JOHN J. SZIKLAS, SAID M. ZUBI
Journal: Clinical Nuclear Medicine (1991)

Two cases of splenic uptake of Tc-99m MDP are presented, in which there was preserved reticuloendothelial activity (Tc-99m sulfur colloid accumulation). In addition to the literature data, data from these cases were used to show the disassociation of uptake of bone agents and radiocolloid in the spleen. Prior reports, in which both agents concentrated in the spleen, were tabulated. An updated gamut on splenic accumulation of Tc-99m MDP or analogues was given.
Prolonged recovery of ultraviolet B-irradiated skin in neuropsin (KLK8)-deficient mice
Authors: T. Kirihara, K. Matsumoto-Miyai, Y. Nakamura, T. Sadayama, S. Yoshida, S. Shiosaka
Journal: British Journal of Dermatology (2003)

Background Neuropsin (KLK8), a serine protease of the kallikrein family, is thought to be involved in the function of keratinocytes, i.e. migration, differentiation and desquamation. However, how neuropsin participates is still unknown. Objective To observe the epidermal function of serine protease in neuropsin‐deficient mice. Methods We irradiated the skin of neuropsin‐deficient mice with ultraviolet light to induce acute inflammation and compared the morphology with that of wild‐type mice. Results We observed a phenotypic change in the epidermis. An acute inflammatory dose of ultraviolet light induced a marked increase in neuropsin mRNA expression in the skin. The signal intensity of the mRNA expression was highest on day 2–3 after irradiation, when keratinocytes were aligned irregularly in the recovery period. Morphological comparison between neuropsin –/– and +/+ mice revealed that an irregular alignment of cells in the thickened epidermis was obvious on day 2 after irradiation in the wild‐type mice, whereas it was prolonged for at least 2 days in the neuropsin‐deficient mice. The stratum corneum of neuropsin‐deficient mice was remarkably thicker than that of the wild‐type mice at 5, 14 and 21 days after irradiation. The increase, as a response to this stimulus, in involucrin immunoreactivity, a marker for cell envelope assembly, was delayed in the mutant mice. Conclusions Thus, neuropsin might be involved early in the process of differentiation, such as in the assembly of the cell envelope, but not in migration and desquamation.
Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion
Authors: Leonard Berlin
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accuracy of Plasma Glucose Measurements in the Hypoglycemic Range
Authors: Pauline M Genter, Eli Ipp
Journal: Diabetes Care (1994)

OBJECTIVE This study was designed to evaluate three different enzymatic methods for glucose measurement in plasma samples with special emphasis on glucose concentrations in the hypoglycemic range. RESEARCH DESIGN AND METHODS Glucose dehydrogenase (Hemo- Cue analyzer), glucose oxidase (YSI analyzer), and hexokinase (Abbott analyzer) methods were used to measure plasma samples that were obtained during research studies. RESULTS Mean glucose concentrations (n = 240) were 5.3 ± 0.2, 5.4 ± 0.2, and 5.6 ± 0.2 mM (95.6 ± 3.9, 96.7 ± 3.9, and 101.6 ± 4.0 mg/dl) using glucose dehydrogenase, glucose oxidase, and hexokinase, respectively (NS). In the hypoglycemic range, mean glucose concentrations with each method retained the same hierarchy of measurements: 2.7 ± 0.05, 2.8 ± 0.04, and 2.9 ± 0.03 mM (48.4 ± 0.9, 50.6 ± 0.8, and 52.3 ± 0.6 mg/dl) by glucose dehydrogenase, glucose oxidase, and hexokinase, respectively (P &amp;lt; 0.005). Individual glucose dehydrogenase measurements (n = 240) correlated well with glucose oxidase and hexokinase, r = 0.99, and were considerably easier to perform at the bedside. The differences between the glucose measurement methods were consistent and similar in low, normal, and high concentration ranges. CONCLUSIONS We conclude that any interpretation or comparison of critical clinical and research measurements of glucose in different settings take into account methodological differences, particularly in the hypoglycemic range.
GIARDIA INTESTINALIS IN THE KIDNEY
Authors: Teresa Malamud
Journal: JAMA (1930)

<h3>To the Editor:</h3> —I read inThe Journal, May 10, the article by Drs. E. W. Ayer and J. M. Neil on the finding of<i>Giardia intestinalis</i>in the kidney pelvis, the authors thinking this is the first case recorded. At the Nov. 19, 1928, session of the Society of Internal Medicine held in Buenos Aires, I communicated in collaboration with others a case (a reprint account of which is attached) in which<i>Giardia</i>was found several times in the bladder as a result of ureteral soundings. Therefore I think that our case was the first one recorded.
A New Department for Venereal and Sexually Transmitted Diseases
Authors: R. D. Catterall, J. R. Seale
Journal: BMJ (1965)

A new department for the diagnosis and treatment of the venereal and sexually transmitted diseases was opened at the Middlesex Hospital early this month. The department is situated in a new five-story building adjacent to the out patient department, the Medical School, and the new Arthur Stanley House for rheumatic diseases. It is called James Pringle House after the famous Middlesex Hospital dermatologist.
EXTENDED MHC HAPLOTYPES IN 21-HYDROXYLASE-DEFICIENCY CONGENITAL ADRENAL HYPERPLASIA: SHARED GENOTYPES IN UNRELATED PATIENTS
Authors: E Fleischnick, D Raum, S.M Alosco, P.S Gerald, E.J Yunis, Z.L Awdeh, J Granados, J.F Crigler, C.M Giles, C.A Alper
Journal: The Lancet (1983)
Neurological Urology: Physiology of Micturition, Its Neurological Disorders and Sequelae
Authors: Rodney A. Mannion
Journal: JAMA (1971)

When I was a resident, Dr. Bors was called to my hospital to reorganize the urological spinal cord injury clinic. He had a precise professional attitude then and always thought of the ulimate welfare of the patient. I now see these qualities in great measure in his writing. This book is divided into two major parts. The first presents basic principles and the second is clinical. This last, comprising almost two thirds of the entire volume, contains in chapter 6 the author's classification of the neurogenic bladder. Here is defined the concept of the "balanced bladder," that is, one with less than 10% of total capacity as residual urine. The bibliography has over 2,000 items. Surgically, the authors are convincingly conservative, especially when treating the "spinal man," as they call the patient with spinal cord injury. They caution against operative adventure unless it is the obviously less injurious course. The
A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys
Authors: Alexander D. Douglas, G. Christian Baldeviano, Carmen M. Lucas, Luis A. Lugo-Roman, Cécile Crosnier, S. Josefin Bartholdson, Ababacar Diouf, Kazutoyo Miura, Lynn E. Lambert, Julio A. Ventocilla, Karina P. Leiva, Kathryn H. Milne, Joseph J. Illingworth, Alexandra J. Spencer, Kathryn A. Hjerrild, Daniel G.W. Alanine, Alison V. Turner, Jeromy T. Moorhead, Kimberly A. Edgel, Yimin Wu, Carole A. Long, Gavin J. Wright, Andrés G. Lescano, Simon J. Draper
Journal: Cell Host & Microbe (2015)

Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum reticulocyte binding protein homolog 5 (PfRH5), a merozoite adhesin required for erythrocyte invasion, is highly susceptible to vaccine-inducible strain-transcending parasite-neutralizing antibody. In vivo efficacy of PfRH5-based vaccines has not previously been evaluated. Here, we demonstrate that PfRH5-based vaccines can protect Aotus monkeys against a virulent vaccine-heterologous P. falciparum challenge and show that such protection can be achieved by a human-compatible vaccine formulation. Protection was associated with anti-PfRH5 antibody concentration and in vitro parasite-neutralizing activity, supporting the use of this in vitro assay to predict the in vivo efficacy of future vaccine candidates. These data suggest that PfRH5-based vaccines have potential to achieve strain-transcending efficacy in humans.
Extracorporeal shockwave lithotripsy for renal calculi: an unusual cause of common bile duct stricture
Authors: S. Ahlawat, T. Fishbein, F. Al-Kawas
Journal: Endoscopy (2007)

Pancreatic and hepatobiliary complications due to extracorporeal shockwave lithotripsy (ESWL) treatment for renal calculi are very rare [1]. ESWL-related biliary stricture mimicking malignancy has not been reported to date.
Abstract 2662: Racial disparities in the surgical outcomes after esophagectomy for esophageal cancer
Authors: Clifford Akateh, Lili Zhao, Mark B. Orringer, Andrew C. Chang, Jules Lin, Rishindra M. Reddy
Journal: Cancer Research (2012)

Abstract Introduction: Despite advances in the management of esophageal cancer, African American patients continue to have poorer outcomes following esophagectomy for esophageal cancer. The reasons for this are multifactorial, including access to care and cultural perceptions of treatments. For those patients who underwent esophagectomy, we sought to evaluate if there were disparities in outcomes for African American patients. Method: We identified African American and Caucasian patients who underwent esophagectomy for esophageal cancer at a single, high volume institution. from 1974 to 2011. Using Chi-square and Fisher's exact test, we evaluated for differences in perioperative risk factors, postoperative complications and long term survival. Results: 2090 (2.7% African Americans, 97.3% Caucasians) patients were included in the study. No significant difference was seen in anastomotic leaks, chylothoraces, hoarseness, or other postop complications. However, more African Americans were sent to the intensive care unit during their postop hospitalization (62% versus 46%, p= 0.02). In addition, African Americans had a significantly longer hospitalization compared to their Caucasian counterparts (19 versus 12 days, p&amp;lt;0.0001). This difference persisted even after adjusting for histology, preoperative staging, age, gender, alcohol and tobacco use. Squamous cell cancer was more likely to be seen in African Americans than in Caucasians (79% versus 20% respectively, p&amp;lt;0.0001). Adenocarcinoma was more often seen in Caucasians than African Americans (78% vs 21%, p&amp;lt;0.0001) as were Barrett's changes (33% versus 10%, p=0.003). Despite the longer hospitalizations, there was no significant difference in the long term survival (weeks) between African Americans and Caucasians. Conclusion: African Americans have equal survival to Caucasians after esophagectomy for esophageal cancer at single, high volume institution. Despite having longer hospitalizations with more ICU admissions after surgery, there were no significant differences in postoperative complications or long term survival based on race. Differences in outcomes in patients with esophageal cancer may be related to initial access to care, but there doesn't appear to be a difference in outcomes once patients proceed to surgery at an experienced center. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2662. doi:1538-7445.AM2012-2662
COMPARISON OF ULTRASOUND AND BILIARY SCINTIGRAPHY IN DETECTING BILIARY PANCREATITIS
Authors: A N Serafini, W Al-Sheikh, M Hourani, G N Sfakianakis, F Ashkar, L Clarke, J S Barkin
Journal: Clinical Nuclear Medicine (1981)

Serafini, A N; Al-Sheikh, W; Hourani, M; Sfakianakis, G N; Ashkar, F; Clarke, L; Barkin, J S Author Information
Tentative d’approche du vécu du dialyse chronique
Authors: J. Cor, D. Becker, S. Delons
Journal: Psychotherapy and Psychosomatics (1972)

Sixteen patients aged 17 to 24 years on chronic dialysis at the Edouard Rist Centre were interviewed individually during 1970. From the material they obtained, the authors attempt to appreciate the experience of these patients. This experience appears to have become trivial. The dialysis patient seems to protect himself from his fear of death by a number of more or less related mechanisms: minimalization, isolation, displacement, projection and regression are the principal ones. These mechanisms appear to be fragile. The attitude of these patients towards transplantation should this be necessary is then considered: they rarely refuse, though their desire is mostly rather ambivalent.
A Post-graduate Lecture ON THORACIC ANEURYSM: Delivered at the Medical Graduates' College and Polyclinic
Authors: D. Drummond
Journal: BMJ (1908)

THROUGHOUT the country It is certain diseases are more prevaleit in some parts than others, and In some instandes this Is so proniounced that special districts may besald to be the' home of certain diseases.In this sense there can be no doubt 'that the 'district 61 Tyneside (iacluding neighbmuring seaports), which Newcastle may be said to be the is linked with thoracic aneurysm.So numerous are cases thalt It Is not uncommon to find five or six of the Newracatle Royal Victoria Infirmary time.It is remarkable, however,' that this applies to aneurysm affecting the thoracic for abdominal aorta are rare, whilst surgical In shape of axillary, brachial, popliteal, are distinctly uncommon in the district.ETIOLOGY.