tbuckley/cabot-search huggingface dataset:
Effects of verapamil on infarct size following experimental coronary occlusion
Authors: H. J. SMITH, B. N. SINGH, H. D. NISBET, R. M. NORRIS
Journal: Cardiovascular Research (1975)

Journal Article Effects of verapamil on infarct size following experimental coronary occlusion Get access H. J. SMITH, H. J. SMITH From the Departments of Cardiology and Coronary Care, Green Lane Hospital and the Department of Medicine, Auckland University School of Medicine, Auckland, New Zealand Search for other works by this author on: Oxford Academic PubMed Google Scholar B. N. SINGH, B. N. SINGH From the Departments of Cardiology and Coronary Care, Green Lane Hospital and the Department of Medicine, Auckland University School of Medicine, Auckland, New Zealand Search for other works by this author on: Oxford Academic PubMed Google Scholar HEATHER D. NISBET, HEATHER D. NISBET From the Departments of Cardiology and Coronary Care, Green Lane Hospital and the Department of Medicine, Auckland University School of Medicine, Auckland, New Zealand Search for other works by this author on: Oxford Academic PubMed Google Scholar R. M. NORRIS R. M. NORRIS From the Departments of Cardiology and Coronary Care, Green Lane Hospital and the Department of Medicine, Auckland University School of Medicine, Auckland, New Zealand Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 9, Issue 4, July 1975, Pages 569–578, https://doi.org/10.1093/cvr/9.4.569 Published: 01 July 1975
Torture and Ill-Treatment: Israel's Interrogation of Palestinians from the Occupied Territories
Authors: J. Immanuel
Journal: BMJ (1995)

Human Rights Watch/Middle East, Human Rights Watch, $20, pp 316, ISBN 1 56432 136 3

To a human rights organisation whether a country is a liberal democracy or a dictatorship does not make much difference in assessing its human rights record. Even liberal states look to their security first. Human rights organisations look to internationally sanctioned moral principles. The two rarely meet.

In Torture and Ill-Treatment there is little discussion of Israel's political problem, which continues to develop new forms, only Israel's reaction to acts of violence against it. Yet the real issue is whether it uses disproportionate violence to stop violent attacks against its citizens. The book is worth reading for the accounts it gives of torture, which should always be exposed; but it would be better if it could …
Cat, fox, dog
Authors: Colin Douglas
Journal: BMJ (2004)

At the bottom of our garden is a high and sturdy old wall shaded by trees. Along with our neighbours' garden walls, similarly old, it provides a useful off-road network for local wildlife: squirrels, cats, and foxes. My study overlooks it and sometimes, when computer screen or blank paper fails to fascinate, it provides passing interest as animals come and go.

The squirrels need not concern us. They are wary and fast and do not linger under …
Catheter Migration During Home Hyperalimentation
Authors: James L. Mullen
Journal: JAMA (1977)

SILASTIC catheters for long-term central venous angio-access have contributed to the efficacy of home hyperalimentation. They have decided advantages over conventional polyethylene and polyvinyl catheters, including flexibility without kinking, minimal thrombogenicity, and few septic complications.<sup>1</sup> Our case report details the migration of a Silastic catheter after long-term permanent implantation, its clinical sequelae, and necessary therapeutic maneuvers. <h3>Report of a Case</h3> A 23-year-old man was admitted from another hospital after initial treatment for gangrenous midgut volvulus secondary to malrotation of the colon. After resolution of numerous complications, intestinal continuity was reestablished with a duodenocolostomy. Long-term home hyperalimentation was instituted after placement of a permanent Broviac Silastic subclavian catheter via the right cephalic vein. Catheter position in the right atrium was confirmed postoperatively by x-ray examination. After five months of asymptomatic, uneventful home parenteral nutrition, the patient noted the gradual onset of right-sided cervical and suprascapular pain, consistently accentuated by the
Abstract 4591: Biotinylated derivatives of selective high affinity ligand (SHAL) therapeutics as companion diagnostics for prescreening non-Hodgkin's lymphoma patients
Authors: Rod Balhorn, Robert B. Rebhun, Saphon Hok, Richard Baum, Jorg Sanger, Monique Cosman Balhorn
Journal: Cancer Research (2012)

Abstract Selective High Affinity Ligands (SHALs) are a new class of small molecule targeting agents that can be designed to bind selectively and with high affinity to unique sites located on almost any protein. A series of SHAL-based therapeutics have been developed to target the cell surface antigen HLA-DR10 that is over-expressed on many B-cell derived malignancies. SHALs are created by first identifying subsets of potential ligands, or “recognition elements,” that bind to two or three neighboring unique sites on the surface of the target protein. Bidentate or tridentate SHALs are produced by linking two or three of these recognition ligands together using carbodiimide chemistry and a miniPEG and lysine scaffold. SHAL synthesis is rapid, uses relatively inexpensive, commercially available components, and is very versatile. Multiple forms of the SHAL can be created by combining different recognition elements (ligands) or by attaching a variety of tags (biotin, chelating groups, dyes, inhibitors) to the end of the linker. Using this approach, SH7139 has been developed as a promising therapeutic for treating non-Hodgkin's lymphoma. Previous studies have shown SH7139 to be effective in treating human B-cell lymphoma in a mouse xenograft model at extremely low doses (3.3μg/kg); 70% of the tumors disappeared within 30 days after treatment and did not reoccur during the remainder of the life of the animal. Here we report that a biotinylated derivative of SH7139 can be used as companion diagnostic to prescreen needle aspirates or biopsies from B-cell lymphomas and determine whether or not the tumor is likely to respond to SH7139 therapy. The staining protocol involves detecting the bound biotinylated SHAL using commercially available alkaline phosphatase reagents, and it works equally well with both fixed and unfixed biopsy sections. Biotinylated SH7139 has been used to identify potentially responsive B-cell lymphomas in both canine and human patients. The development of SHAL-based diagnostics in parallel with new SHAL-based therapeutics will help advance individualized therapies and minimize the systemic trauma and valuable time lost by patients given treatments that prove to be ineffective. Our results also suggest this diagnostic may also prove useful in determining whether malignancies over-expressing HLA-DR10 have metastasized and individual lymphoma cells have migrated out of the tumor into surrounding normal tissue. This research was supported, in part, by NIH/NCI SBIR grant 1R43CA159843-01 to Rod Balhorn. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4591. doi:1538-7445.AM2012-4591
Combating Medicare Fraud
Authors: Mike Mitka
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nitric oxide regulation of myocardial contractility and calcium cycling: Independent impact of neuronal and endothelial nitric oxide synthases
Authors: Shakil A. Khan, Michel W. Skaf, Kwangho Lee, Robert W. Harrison, Micheal Fradley, Artin A. Shoukas, Dan E. Berkowitz, Joshua M. Hare
Journal: Journal of the American College of Cardiology (2003)
Portacaval Graft Patency Demonstrated by Scintigraphic Calculation of Portal Contribution to Hepatic Blood Flow
Authors: J MART??N-COM??N, M I SEGARRA, J PUJOL, L MAIRAL, L SANS, J MORA, R PUCHAL
Journal: Clinical Nuclear Medicine (1992)

The case presented refers to a cirrhotic patient with portal hypertension in whom a portacaval graft bypass was surgically implanted. The calculation of the portal contribution to hepatic blood flow helped to demonstrate the patency of the graft.
On the Illinois Frontier: Dr. Hiram Rutherford, 1840-1848
Authors: E. Dorinda Shelley
Journal: JAMA (1984)

<b>Medical Care in Pioneer Illinois</b>, by John K. Crellin (<i>Medical Humanities Series</i>, Glen W. Davidson, ed), 128 pp, 20 illus, $15.95, Springfield, Pearson Museum, Southern Illinois University School of Medicine, 1982. These two short books give complementary insight into medical practice in downstate Illinois during the mid-1800s. While one is a contemporary account of establishing a practice in a small town, the other is a fact-filled overview of medical trends, economics, and diseases. Dr Rutherford's courtship and family letters (1841 to 1848) present a vivid and vital slice of pioneer life in Independence, Ill (later Oakland), where he was the only medical-school-trained physician. In the early years his practice consisted mainly of house calls, requiring long hours on horseback through soaking rains, blizzards, deep mud, high water, forests, and prairies. He particularly loved the prairies: "The eye will never tire of the flowers of the wilderness and of the prairie:
Abstract 179: MicroRNA-29c functions as a tumor suppressor by direct targeting endogenous SIRT1 in hepatocarcinogenesis
Authors: Hyun Jin Bae, Ji Heon Noh, Jeong Kyu Kim, Jung Woo Eun, Kwang Hwa Jung, Min Kyu Kim, Young Gyoon Chang, Won Sang Park, Suk Woo Nam
Journal: Cancer Research (2012)

Abstract SIRT1 (Sirtuin 1) is the most well-known member of the class III histone deaceylase family which plays key roles in many cellular pathways by deacetylating or interacting with numerous non-histone proteins. Recent evidence has demonstrated that SIRT1 is up-regulated in a variety of human cancers and inhibition of SIRT1 expression or activity induces cancer cell growth retardation, cell cycle arrest and apoptosis. Although the functions of SIRT1 in cancer have been extensively studied, the underlying mechanisms of aberrant regulation of SIRT1 are not clearly understood. In the present study, we identified 5 microRNAs (miRNAs) that were significantly down-regulated in human hepatocellular carcinomas (HCCs) via large-scale miRNA expression analysis with computational prediction of miRNA targeting for SIRT1. Of these, it was found that miR-29c and miR-141 were directly able to suppress endogenous SIRT1 expression, but only miR-29c was able to recapitulate the effects of SIRT1 inactivation in HCC cells. In addition, the expression level of miR-29c was inversely correlated with SIRT1 protein expression levels in a subset of HCC tissues with their corresponding noncancerous tissue. The ectopic expressions of miR-29c in SNU-182 liver cancer cell lines suppressed cell growth and induced cell cycle arrest at G1-phase accompanied with the altered expressions of G1-related cellular components, such as CDK6, CDK2, cyclin D1, cyclin D3, phosphorylation of Rb and E2F1. Taken together, we suggest that loss or down-regulation of endogenous miR-29c causes aberrant overexpression of SIRT1 contributing oncogenic potential to the cells, and that a novel tumor suppression mechanism involving miR-29c may be amenable to epigenetic regulation in human HCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 179. doi:1538-7445.AM2012-179
Peter Michael Roemmele
Authors: Ailbe Beirne
Journal: BMJ (2008)

Peter was born in Osterley, in the London suburbs, on 28 July 1920, the youngest son of a former immigrant, a German speaking general practitioner, and a nurse from County Donegal. Educated at Haileybury, an austere boarding school, he excelled academically and was a rower, champion shot at Bisley, a school chorister, developing a lifelong love of classical music.

Early holidays were spent in Connemara, where his father had a fishing lodge, and from the age of 4 he developed an enthusiasm for fishing, which was to play an important part in his adult life.

After school Peter went to Edinburgh University to study medicine, graduating in 1943, ahead of others in his year, and he was the recipient of the rarely awarded Anndale gold medal for clinical surgery.

He graduated in 1943, and joined the Royal Naval Volunteer …
"Collagen Diseases" and the Lung
Authors: R. H. KAMPMEIER
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 November 1973"Collagen Diseases" and the LungR. H. KAMPMEIER, M.D., M.A.C.P.R. H. KAMPMEIER, M.D., M.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-759_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Eisenberg and associates (Ann Intern Med 79:37-45, 1973) recalls a paper, "Pulmonary Manifestations of the Collagen Diseases," by myself and W. B. Wilson, read at the 6th International Congress on Gerontology, Copenhagen, in August 1963, but not published. The abstract follows.Elsewhere one of us (1-5) (RHK) has considered: (a) the possible and not unusual chronicity of these diseases; (b) that antigen-antibody reactions need interpretation in terms of acuity or chronicity, site of the lesions, and size of blood vessels involved; (c) that renal glomeruli offer a common ground in which end results meet...References1. KAMPMEIER R: Vascular diseases due to hypersensitivity: so-called diffuse collagen diseases, Am Pract 1:113-121, 1950 Google Scholar2. KAMPMEIERSHAPIRO RJ: The diverse and sometimes recurrent course of diffuse arteritis, Trans Assoc Am Physicians 65:323-336, 1952 MedlineGoogle Scholar3. KAMPMEIERSHAPIRO RJ: Diffuse and sometimes recurrent course of diffuse arteritis; observations and report of a patient observed for twenty-one years, Arch Intern Med 92:856-879, 1953 CrossrefGoogle Scholar4. KAMPMEIERSMITH RL: Diffuse arteritis as a recurrent disease, Trans Am Clin Climatol Assoc 65:232-259, 1953 MedlineGoogle Scholar5. KAMPMEIER R: Collagen diseases-unanswered questions on pathogenesis and etiology (Chairman's address, Section on Internal Medicine, AMA) Arch Intern Med 106:753-785, 1960 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Vanderbilt University Nashville, Tennessee PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1973Volume 79, Issue 5Page: 759-760KeywordsAntigensBlood vesselsChronic kidney diseaseCollagen diseasesGeriatricsLesionsLungsPulmonary diseases Issue Published: 1 November 1973 PDF DownloadLoading ...
Continuous measurement of left ventricular performance during and after maximal isometric deadlift exercise.
Authors: J Sullivan, P Hanson, P S Rahko, J D Folts
Journal: Circulation (1992)

Isometric exercise produces a reflex increase in arterial blood pressure that is proportional to the intensity and mass of muscle used during contraction. Little is known about the transient effects of heavy weight lifting on left ventricular performance. In this study, we measured continuous changes in left ventricular performance during maximal large-muscle isometric exercise using the standing deadlift position.Ten healthy young men performed serial deadlifts at 50% of maximal voluntary effort for 90 seconds and 100% of maximal effort for 30 seconds. Echocardiographic imaging (apical four-chamber view), arterial blood pressure (brachial artery catheter), and electrocardiographic monitoring were recorded throughout the deadlift and for 30 seconds of recovery. Aortic flow velocity was also monitored during a separate series of deadlifts. During 100% maximal deadlift, mean arterial pressure increased from 108 +/- 4 to 164 +/- 6 mm Hg. Left ventricular ejection fraction declined initially (from 57 +/- 2% to 49 +/- 3%) at 15 seconds into the lift and recovered (56 +/- 1%) due to significant increases in end-diastolic volume (104 +/- 11 ml to 132 +/- 16 ml) by the end of the lift. The peak systolic pressure/end-systolic volume ratio did not change during the deadlift. After cessation of the deadlift, mean arterial pressure declined precipitously (to 88 +/- 4 mm Hg) within 5 seconds and gradually returned to baseline after 30 seconds. Left ventricular performance indexes all increased significantly during the recovery phase (ejection fraction to 68 +/- 3%, peak systolic pressure/end-systolic volume ratio to 5.9 +/- 0.9). Findings were qualitatively similar for the 50% deadlift.During an intense isometric deadlift, left ventricular performance declines initially but is restored by the Frank-Starling mechanism. Upon release of the deadlift, increased left ventricular performance develops in conjunction with a rapid decrease in arterial pressure. The combined effects of increased wall stress during the lift phase and enhanced contractility during the release phase probably contribute to left ventricular hypertrophy associated with repetitive weight training.
Successful Granulocyte Transfusion Therapy for Gram-Negative Septicemia
Authors: Roger H. Herzig, Geoffrey P. Herzig, Robert G. Graw, Malcolm I. Bull, Karyl K. Ray
Journal: New England Journal of Medicine (1977)

We prospectively randomized 27 granulocytopenic patients who experienced a total of 30 episodes of gram-negative septicemia. The control group received an appropriate antibiotic regimen alone, whereas the "transfusion" group received infusions of granulocytes in addition to the antibiotics. Five of 14 controls survived, and 12 of 16 in the transfusion group survived, and 12 of 16 in the transfusion group survived (P less than 0.04). An important factor in the outcome of treatment was the recovery of bone-marrow function (return of peripheral granulocyte count greater than or equal to 1000 per microliter). Eighty-three per cent (five of six) of the control group and all (four of four) of the transfusion group with recovery of granulocyte levels survived the episode of sepsis. In contrast, none of the eight control patients, as compared to 67 per cent (eight of 12) of the transfusion group, survived persistent granulocytopenia (P less than 0.005). Granulocyte transfusions appear to complement appropriate antibiotic treatment of gram-negative-septicemia due to granulocytopenia.
T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates
Authors: Donald B. Kohn, Michal S. Hershfield, Denise Carbonaro, Ann Shigeoka, Judith Brooks, E. Monika Smogorzewska, Lora W. Barsky, Raymond Chan, Felix Burotto, Geralyn Annett, Jan A. Nolta, Gay Crooks, Neena Kapoor, Melissa Eldetr, Diane Wara, Thomas Bowen, Edward Madsen, Floyd F. Synder, John Bastian, Linda Muul, R. Michael Blaese, Kenneth Weinberg, Robertson Parkman
Journal: Nature Medicine (1998)
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
Authors: Sumio Hayakawa, Souichi Shiratori, Hiroaki Yamato, Takeshi Kameyama, Chihiro Kitatsuji, Fumi Kashigi, Showhey Goto, Shoichiro Kameoka, Daisuke Fujikura, Taisho Yamada, Tatsuaki Mizutani, Mika Kazumata, Maiko Sato, Junji Tanaka, Masahiro Asaka, Yusuke Ohba, Tadaaki Miyazaki, Masahiro Imamura, Akinori Takaoka
Journal: Nature Immunology (2010)
Vascular Response Differences in Field Dependency
Authors: Albert J. Silverman
Journal: Psychotherapy and Psychosomatics (1982)

Field-dependent (FD) subjects (Ss) differ psychophysiologically from field-independent (FI) Ss who are more differentiated psychologically and more cerebrally lateralized. This paper reviews vascular differences in these two groups in a series of five experiments. First noted was that withdrawing blood from FD Ss was more difficult, suggesting superficial vein constriction or spasm. Additionally, FD Ss did not respond to insulin-induced hypoglycemia with the expected pulse rate and systolic blood pressure rise and diastolic decrease, while FI Ss did show these changes. In a second experiment, arm veins of FD Ss revealed higher resting pressures than FI Ss, until after stimulation. Both groups displayed similar higher pressures during nonspecific stimuli (white noise), while FI Ss responded more to specific stimuli (words, arithmetic). A third experiment investigating the rate of blood flow in a superficial arm vein demonstrated decreasing resting rates over time only in FD Ss: while overall, FI Ss revealed faster resting rates, and in sustained response to a dose of epinephrine. A fourth and fifth experiment exposing these groups to different doses of epinephrine or alcohol revealed poorer dose responses among FD Ss with diastolic blood pressure and pulse rates. These Ss appear to be more responsive to novelty than to differing dose levels of CNS active drugs or other specific stimuli.
Health Effects in Survivors of the Chernobyl Disaster
Authors: Michael R. Quastel
Journal: JAMA (1996)

To the Editor.  —We read with great interest the article by Dr Weinberg and colleagues 1 and agree with their emphasis that people exposed to radiation from nuclear accidents should undergo thorough examinations by physicians, with particular attention given to the thyroid in children. We suggest attention to the following additional findings.  Researchers at the Ben Gurion University of the Negev-Soroka Medical Center have carried out biomedical examinations of more than 2000 adults and children who immigrated to Israel from Belarus, Ukraine, and southern Russia near Chernobyl. Psychosocial interviews were conducted with an additional 700 people, of whom half were controls matched by age, sex, and year of immigration who had come from areas of the former Soviet Union that were unexposed to Chernobyl radiocontamination. The Bar Ilan University group has examined groups of salvage workers (liquidators) for potential radiation effects on the male reproductive system. Some observations include the