tbuckley/cabot-search huggingface dataset:
The Effects of 8-Hydroxy-2-(di-<i>n</i>-propylamino)tetralin on the Cholinergic Contraction in Guinea Pig and Human Airways <i>In Vitro</i>
Authors: LIEVEN J. DUPONT, JAN L. PYPE, MAURITS G. DEMEDTS, PAUL DE LEYN, GEORGES DENEFFE, GEERT M. VERLEDEN
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Electrical field stimulation of guinea pig tracheal strips and human bronchial rings, in vitro, evokes a cholinergic contraction mediated by the release of acetylcholine. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is a 5-HT1A and 5-HT7 agonist. In this study, we have investigated whether 8-OH-DPAT could modulate the cholinergic contraction in guinea pig and human airways in vitro. 8-OH-DPAT (1 to 30 μ M) produced a concentration-dependent inhibition of the cholinergic contraction in guinea pig tracheal strips with a maximal inhibition of 75.8% ± 4.7% (30 μ M, 0.5 Hz). Pretreatment of the tissues with the 5- HT1/2/7 antagonist methysergide (10 to 30 μ M) significantly attenuated the inhibitory effects of 8-OH-DPAT (10 to 30 μ M) on the cholinergic contraction. Pretreatment with ketanserin (10 μ M), a 5-HT2 antagonist, tropisetron (1 μ M), a 5-HT3/4 antagonist, SDZ 216-525 (1 to 10 μ M) and pindobind (10 μ M), both selective 5-HT1A antagonists, or capsaicin (10 μ M), which depletes sensory nerves from neuropeptides, had no effect on the inhibition of the cholinergic contraction by 8-OH-DPAT (10 to 30 μ M). 5-carboxamidotryptamine (5-CT) (10 to 100 μ M), a 5-HT1/2/7 agonist, partially mimicked the inhibitory effects of 8-OH-DPAT on the cholinergic contraction. 8-OH-DPAT (10 to 30 μ M) also inhibited the cholinergic contraction in human bronchial rings in vitro with a maximal inhibition of 46.2% ± 7.2% (30 μ M, 1 Hz). SDZ 216-525 (10 μ M) had no effect, whereas methysergide (30 μ M) partially prevented the effect of 8-OH-DPAT in human airways. 8-OH-DPAT (30 μ M) did not displace the concentration–response curve to acetylcholine (10 nM-30 mM) in guinea pig and human airways in vitro. These results suggest that 8-OH-DPAT inhibits the cholinergic contraction in guinea pig and human airways in vitro through stimulation of prejunctional atypical 5-HT receptors, possibly of the 5-HT7 subtype, located on postganglionic cholinergic nerves.
On the Stresses of Community Psychiatry, and Helping Residents To Survive Them
Authors: ANDREW P. MORRISON, MILES F. SHORE, JERALD GROBMAN
Journal: American Journal of Psychiatry (1973)

The authors underscore the major themes that challenge the resident who moves into community work from his initial experience as an individual therapist. The resident must be able to change, especially in terms of his own role expectations, to expand his repertoire of professional techniques, and to move from his former relatively passive stance to a new role in which he becomes more active. The supervisor should be ready to guide the resident in his work and be sensitive to his anxieties.
Buschke—Loewenstein tumour infiltrating pelvic organs
Authors: A. GRASSEGGER, R. HOPFL, H. HUSSL, K. WICKE, P. FRITSCH
Journal: British Journal of Dermatology (1994)

We report a 42‐year‐old HIV‐negative patient with a 12‐year history of exceptionally extensive genital warts and coexisting verrucous carcinoma of the anogenital region (Buschke–Loewenstein tumour). Masses of both tumour and viral papillomas infiltrated the external genitalia, perineum and buttocks, pelvic diaphragm and parts of the lesser pelvis, as well as the urethra, prostate and parts of the urinary bladder, necessitating repeated surgical intervention and plastic reconstruction. Adjuvant interferon‐α therapy was given without any lasting effects. Human papillomavirus type 6 was detected by DNA in situ hybridization and Southern blot analysis.
Improving Diabetes Care via Telemedicine: Lessons From the Addressing Diabetes in Tennessee (ADT) Project
Authors: Ebenezer A. Nyenwe, Sydney Ashby, Jamie Tidwell, Simonne S. Nouer, Abbas E. Kitabchi
Journal: Diabetes Care (2011)

The prevalence of diabetes continues to escalate around the world, with an estimated 24 million people affected in the U.S. (1). Its prevalence has more than doubled in Tennessee the last decade from 5.0% in 1997 to 11.0% in 2007 (2), with estimated diabetes related mortality of 31 per 100,000 population (2). Rising prevalence and shortage of physicians, especially in rural areas, contribute to poor outcome in diabetic patients (3). Telemedicine, the transfer of electronic medical data to a remote location utilizing telecommunications technology, may be beneficial in improving access, care, and outcome in diabetic patients. Therefore, we investigated the impact of telemedicine on the quality of care in diabetic patients in five health professional shortage areas with diabetes related mortality rates of 41.5–84.7 per …
Surgery vs Watchful Waiting for Mitral Regurgitation
Authors: Leandro Slipczuk, Roy Beigel, Robert J. Siegel
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
997-89 Effect of Local Angiotensin II Inhibition on Pattern of Ventricular Hypertrophy and Characteristics of Myocardium
Authors: Masakazu Obayashi, Michihiro Kohno, Masahumi Yano, Shigeki Kobayashi, Tsutomu Ryouke, Tomoko Ohkusa, Masunori Matsuzaki
Journal: Journal of the American College of Cardiology (1995)
Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling
Authors: Nikhil Wagle, Caroline Emery, Michael F. Berger, Matthew J. Davis, Allison Sawyer, Panisa Pochanard, Sarah M. Kehoe, Cory M. Johannessen, Laura E. MacConaill, William C. Hahn, Matthew Meyerson, Levi A. Garraway
Journal: Journal of Clinical Oncology (2011)

A detailed understanding of the mechanisms by which tumors acquire resistance to targeted anticancer agents should speed the development of treatment strategies with lasting clinical efficacy. RAF inhibition in BRAF-mutant melanoma exemplifies the promise and challenge of many targeted drugs; although response rates are high, resistance invariably develops. Here, we articulate overarching principles of resistance to kinase inhibitors, as well as a translational approach to characterize resistance in the clinical setting through tumor mutation profiling. As a proof of principle, we performed targeted, massively parallel sequencing of 138 cancer genes in a tumor obtained from a patient with melanoma who developed resistance to PLX4032 after an initial dramatic response. The resulting profile identified an activating mutation at codon 121 in the downstream kinase MEK1 that was absent in the corresponding pretreatment tumor. The MEK1(C121S) mutation was shown to increase kinase activity and confer robust resistance to both RAF and MEK inhibition in vitro. Thus, MEK1(C121S) or functionally similar mutations are predicted to confer resistance to combined MEK/RAF inhibition. These results provide an instructive framework for assessing mechanisms of acquired resistance to kinase inhibition and illustrate the use of emerging technologies in a manner that may accelerate personalized cancer medicine.
Just Playing Doctor
Authors: David Alex Stroh
Journal: Annals of Internal Medicine (2009)

On Being a Doctor17 March 2009Just Playing DoctorDavid Alex Stroh, BSDavid Alex Stroh, BSFrom Johns Hopkins School of Medicine, Baltimore, MD 21205.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-6-200903170-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The first thing I learned from the county hospital: Put on any color coat, and folks will call you “doc.” Every time they said it, I breathed a quick reminder that I wasn't a doctor, as of yet. Still it felt like a game—putting on my cloak of illusion and temporarily stepping into a different world. But, like many others, I was experiencing things that would be important in either helping me to actually get there or sending me running in the other direction. Both receiving and giving training, after all, is a big part of being a doctor. If ... Author, Article, and Disclosure InformationAffiliations: From Johns Hopkins School of Medicine, Baltimore, MD 21205.Corresponding Author: David Alex Stroh, BS, Johns Hopkins School of Medicine, 1620 McElderry Street, Baltimore, MD 21205; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by„Pamiętam, zdarzyło się to w sobotę rano, około 10”. Fachowe publikacje medyczne oparte na relacjach pacjentów i lekarzy 17 March 2009Volume 150, Issue 6Page: 421-422KeywordsForecastingGamesHealth careHeartMedical staffOrthopedicsResidencyRunningSurgeonsTouch ePublished: 17 March 2009 Issue Published: 17 March 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Broadening the Scope of Nursing Practice
Authors: Julie A. Fairman, John W. Rowe, Susan Hassmiller, Donna E. Shalala
Journal: New England Journal of Medicine (2010)

To bridge the gap between demand for primary care and available primary care practitioners and establish new approaches to care delivery, health care providers should be able to practice to the fullest extent of their knowledge and competence. This means establishing a broadened scope of practice for nurse practitioners.
Cost-Benefit of Intensive Care
Authors: MICHAEL H. ALDERMAN
Journal: Annals of Internal Medicine (1973)

Letters, Comments, and Corrections1 February 1973Cost-Benefit of Intensive CareMICHAEL H. ALDERMAN, M.D., F.A.C.P., KATSUHIKO YANO, M.D.MICHAEL H. ALDERMAN, M.D., F.A.C.P.Search for more papers by this author, KATSUHIKO YANO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-2-310 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Griner (Ann Intern Med 77:501-506, 1972) is to be congratulated for calling attention to the need for critical examination of new therapeutic methods. Unfortunately, however, his evidence, although suggestive, does not fully sustain the conclusion that admission to the intensive care unit offered little benefit to the patient.This conclusion was drawn from comparison of groups of patients hospitalized during different years and in different settings. The validity of such a comparison depends on the similarity of the patients involved, yet there is a striking reversal of the sex ratio among those admitted before and after... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Public Health Cornell University Medical College New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInternational Programme for Resource Use in Critical Care (IPOC) - a methodology and initial results of cost and provision in four European countries 1 February 1973Volume 78, Issue 2Page: 310-311KeywordsIntensive care units Issue Published: 1 February 1973 PDF downloadLoading ...
Low-Dose Aspirin and Vitamin E
Authors: Eric J. Jacobs, Michael J. Thun
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia
Authors: Conn L. Hastings, Helena M. Kelly, Mary J. Murphy, Frank P. Barry, Fergal J. O'Brien, Garry P. Duffy
Journal: Journal of Controlled Release (2012)
Discovering early molecular determinants of leukemogenesis
Authors: Grover C. Bagby
Journal: Journal of Clinical Investigation (2008)

Truncating mutations of the G-CSF receptor are found during disease course in nearly half of all patients with severe congenital neutropenia. In this issue of the JCI, Liu et al. demonstrate that these mutations confer a competitive clonal advantage upon HSCs in mice and that the advantage is conditional because it is observed only in the presence of the ligand G-CSF (see the related article beginning on page 946). Once activated, the mutant receptor requires the function of Stat5 in order to effect clonal expansion of this stem cell population. The results support the notion that early molecular steps in this and other neoplastic processes represent adaptations in which, through somatic mutations, “unfit” stem cells gain a measure of fitness by altering their relationships with their microenvironment.
Abstract 1656: Genome wide identification of susceptibility loci in breast cancer survival
Authors: Sujee Jeon, Hyuna Sung, Ji-Yeob Choi, Minkyo Song, Sue K. Park, Keun-Young Yoo, Dong-Young Noh, Wonsik Han, Sei-Hyun Ahn, Daehee Kang
Journal: Cancer Research (2012)

Abstract Background: Recently, many studies have been conducted to identify the susceptibility loci related with breast cancer risk, but few studies have examined the genetic variations for survival. Objectives &amp; Methods: To identify the susceptibility loci for breast cancer recurrence or all-cause of death, genome wide survival analysis were performed with 2,171 histologically confirmed incident breast cancer cases. For a genetic association study, DNA was genotyped using Affymetrix SNP Array 6.0 including about 0.9 million single nucleotide polymorphisms (SNPs). We examined the association between genetic variance and disease-free survival (DFS) and overall survival (OS) using Cox proportional hazard regression model adjusting for known prognostic factors. Results: During a median of 5.8 years of follow-up, 297 women recurred and 152 women died. Three SNPs in 2 genes (ARHGAP28 and LGI4) and four intergenic SNPs were identified for DFS (Padjusted &amp;lt;10−6) and five SNPs in 4 genes (CADPS, KCNH7, LGI4, and TGFBRAP1) and one intergenic SNP were associated with OS (Padjusted &amp;lt;10−6). Most significant associated SNP with DFS was located in ARHGAP28 (Padjusted =7.40 X 10−7) and this showed decreased risk of recurrence (aHR=0.6, 95% CI=0.50-0.74). SNP of CADPS was most significantly associated with OS (Padjusted = 9.04 X 10−7), and showed increased risk of all-cause of death (aHR=2.1, 95% CI=1.56-2.83). Conclusions: Our results suggest that the promising SNPs might associate with the breast cancer recurrence and survival in Korean women. We will confirm these findings in the replication stages further. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1656. doi:1538-7445.AM2012-1656
A role for complement receptor-like molecules in iron acquisition by Candida albicans.
Authors: M A Moors, T L Stull, K J Blank, H R Buckley, D M Mosser
Journal: The Journal of Experimental Medicine (1992)

Candida albicans, an opportunistic fungal pathogen of humans, is dependent upon iron for growth. Consequently, human serum inhibits C. albicans growth due to the presence of high affinity iron-binding proteins that sequester serum iron, making it unavailable for use by the organism. We report that in the inhibitory environment of human serum, the growth of C. albicans can be restored by the addition of exogenous hemoglobin or heme, but not by protoporphyrin IX, the heme precursor that does not contain iron. We further report that C. albicans can utilize cell surface proteins that are homologues of the mammalian complement receptors (CR) to rosette complement-coated red blood cells (RBC) and obtain RBC-derived iron for growth. The ability of Candida to acquire RBC-derived iron under these conditions is dependent upon Candida-RBC rosetting mediated by CR-like molecules. Unopsonized RBC do not support Candida growth in serum, and restoration of Candida growth in serum by complement-opsonized RBC is inhibited by monoclonal antibodies to the human CR type 3 (CR3). In addition, activation of the human alternative pathway of complement by Candida leads to "bystander" deposition of C3 fragments on the surface of autologous, unopsonized RBC, generating the ligands necessary for Candida-RBC rosetting. These results suggest that C. albicans has evolved a unique strategy for acquiring iron from the host, which exploits the host complement system, and which may contribute to the pathogenic potential of the organism.
Proportion of Flat- and Depressed-Type and Laterally Spreading Tumor Among Advanced Colorectal Neoplasia
Authors: Eisuke Kaku, Yasushi Oda, Yoshitaka Murakami, Hideyo Goto, Tomofumi Tanaka, Kiwamu Hasuda, Makoto Yasunaga, Kiyoharu Ito, Kouichi Sakurai, Takahiro Fujimori, Masahiro Hattori, Yutaka Sasaki
Journal: Clinical Gastroenterology and Hepatology (2011)
Surgical management of appendicitis remains best option during pregnancy
Authors: A. Vasireddy, S. Atkinson, A. Shennan, S. Bewley
Journal: BMJ (2012)

Surgeons contemplating conservative management of acute appendicitis must realise pregnant women were excluded from the meta-analysis by Varadhan and colleagues.1 Two maternal deaths have occurred in London since 2010; both women were treated with antibiotics, seemingly to recover sufficiently to be discharged before readmission with their final illness.

The UK Confidential Enquiry into Maternal Deaths is currently suspended, so we examined all …
OUTCOME FOLLOWING ICD IMPLANTATION WITH VERSUS WITHOUT DEFIBRILLATION TESTING: PRELIMINARY RESULTS OF THE PROSPECTIVE RANDOMIZED TEST-NO TEST (TNT) PILOT STUDY
Authors: Andrea Russo, John Andriulli, Matthew Ortman, Yong-Mei Cha, Rachel Lampert, Julie Field, Heaton Kath, Krystal Hunter, Ulrika Birgersdotter-Green, Jeanne Poole
Journal: Journal of the American College of Cardiology (2014)
CYANOSIS IN INFANTS FROM NITROBENZENE
Authors: A. M. Stevens
Journal: JAMA (1928)

Sept. 12, 1927, a mother brought her twin babies to the Bellevue dispensary. They were 3 weeks old and had been perfectly normal up to September 10, when it was noticed that the lips of both were deep blue. The mother was alarmed at first but was reassured to find that the babies slept and nursed as usual. September 11 was a Sunday when the dispensary was closed, so that nearly forty-eight hours elapsed before the babies were shown to the physician. The mother thought that the blueness was less marked than on the first day. Both babies were of an ashy gray pallor all over the body, with lead-colored finger and toe nails. The lips, tongue and mucosa of the mouth were dark blue. The boy weighed 7 pounds 4 ounces (3.3 Kg.) and the girl 6 pounds 12 ounces (3.5 Kg.). No signs were detected in the lungs or heart, the
Detection and characterization of DNA adducts at the femtomole level by desorption ionization mass spectrometry.
Authors: J O Lay, M P Chiarelli, M S Bryant, R W Nelson
Journal: Environmental Health Perspectives (1993)

Current methodologies for the detection and isolation of carcinogen-DNA adducts have advanced beyond the capabilities of the methods used to elucidate their structures. This difficulty seriously limits the potential use of DNA-carcinogen adducts in human dosimetry. We have investigated two general strategies for the analysis of model arylamine-nucleoside adducts using desorption ionization mass spectrometry (MS). Using fast atom bombardment MS-MS with constant neutral loss scans, we can identify the protonated molecule of derivatized adducts in samples as small as 1 pmole, and then apply daughter ion MS-MS scans to obtain structure-specific fragmentation. Using this strategy we have differentiated adducts having the same carcinogen and different bases [e.g., N-(deoxyadenosin-8-yl)-4-aminobiphenyl and N-(deoxyguanosin-8-yl)-4- aminobiphenyl] or the same base and different carcinogens [e.g., N-(deoxyguanosin-8-yl)-4- aminobiphenyl and N-(deoxyguanosin-8-yl)-2-aminofluorene]. In the second approach we used laser desorption time-of-flight MS to obtain spectra from adduct samples as small as 20 fmole. These data indicate that MS can be used for the analysis of very low (picomole-femtomole) levels of nucleoside adducts, including isomers, and that desorption ionization MS and MS-MS have significant potential for applications in human dosimetry.
Inaccuracy of the Rose/WHO and the Edinburgh modification questionnaires for detecting peripheral arterial disease in patients with coronary artery disease
Authors: Robert S. Dieter, Jon Tomasson, Thor Gudjonsson, Roger Brown, Mark Vitcenda, Jean Einerson, Pamela Douglas, Timothy E. Tanke, Ford Ballantyne, Jonathan C. Makielski, Patrick E. McBride
Journal: Journal of the American College of Cardiology (2003)
Laparoscopically assisted transgastric endoscopy in Roux-en-Y gastric bypass: a modification of the technique
Authors: G. Peeters, J. Himpens
Journal: Endoscopy (2009)

Laparoscopically assisted transgastric endoscopy is a well-accepted strategy to access the papilla of Vater in patients with a bypassed duodenum, as after Roux-en-Y gastric bypass [1] [2] [3]. In this technique the endoscope is introduced into the abdomen through a trocar and is advanced to the duodenum via a gastrotomy. Using this technique however, gastric fluid and endoscopic insufflated air might escape from the gastrotomy during manipulation of the endoscope. The presence of gastric contents inside the peritoneal cavity might cause peritonitis or abscess formation. The presence of insufflated room air in the peritoneal cavity could cause dangerous gas embolisms [4] [5].