Lithium-Induced Granulocytosis
Authors: Richard S. Stein, Gerald Hanson, Susan Koethe, Richard Hansen
Journal: Annals of Internal Medicine (1978)

Brief Reports1 June 1978Lithium-Induced GranulocytosisRICHARD S. STEIN, M.D., GERALD HANSON, M.D., SUSAN KOETHE, Ph.D, RICHARD HANSEN, M.D.RICHARD S. STEIN, M.D., GERALD HANSON, M.D., SUSAN KOETHE, Ph.D, RICHARD HANSEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-6-809_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe administration of lithium has been associated with granulocytosis in psychiatric patients and those with Felty's syndrome. Lithium can attenuate neutropenia in patients receiving cancer chemotherapy (1). The clinical significance of these observations depends on whether lithium increases production of granulocytes or merely delivers to the circulation granulocytes that are marginated or are in the marrow reserve. In this study we measured the circulating and marginated granulocytes and the marrow granulocyte reserves in volunteers before and after the administration of lithium to determine the mechanism of lithium-induced granulocytosis.Six healthy volunteers, aged 24 to 31 years, received lithium carbonate, 300...References1. STEINBEAMANALIHANSENJENKINSJUME'AN RCMRDH: Lithium carbonate attenuation of chemotherapy-induced neutropenia. N Engl J Med 297:430-431, 1977 CrossrefMedlineGoogle Scholar2. DALEFAUCIGUERRYWOLFF DADS: Comparison of agents producing a neutrophilic leukocytosis in man. Hydrocortisone, prednisone, endotoxin, and etiocholanolone. J Clin Invest 56:808-813, 1975 CrossrefMedlineGoogle Scholar3. SAMUELS A: Primary and secondary leukocyte changes following the intramuscular injection of epinephrine hydrochloride. J Clin Invest 30:941-947, 1951 CrossrefMedlineGoogle Scholar4. HARKERROTHSTEINCLARKSONATHENSMACFARLANE WGDJJ: Enhancement of colony-stimulating activity production by lithium. Blood 49:263-267, 1977 CrossrefMedlineGoogle Scholar5. TISMANHERBERTROSENBLATT GVS: Evidence that lithium induces human granulocyte proliferation: elevated serum vitamin B12 binding capacity in vivo and granulocyte colony proliferation in vitro. Br J Haematol 24:767-771, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySaliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: Identification of clinical and environmental covariates, and their incorporation into a prediction modelLithium in the treatment of neutropeniaRestarting Clozapine after NeutropeniaContinuing clozapine treatment despite neutropeniaThe effects of prolonged lithium exposure on the immune system of normal control subjects: Serial serum soluble interleukin-2 receptor and antithyroid antibody measurementsLithium-induced hematologic changes in patients with bipolar affective disorderLeukemia in Bipolar Mood Disorder: Is Lithium Contraindicated?Effect of Lithium on Blood Cells and the Function of GranulocytesReactions to LithiumRelease of Growth Promotors from Mononuclear Human Blood Cells by LPS, Lectins and Lithium, as Tested in the Mouse CFU-C AssayBone Marrow Transplantation for the Treatment of Severe Aplastic AnaemiaInfluence of lithium and fluoride on degranulation from human neutrophils in vitroReferencesLithium carbonate and granulocyte production: Dose optimizationEffect of lithium on normal and chronic granulocytic leukemia colony forming cells (CFU-GM)Aplastic Anemia: Biology and TreatmentROBERT PETER GALE, M.D., Ph.D., RICHARD E. 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FITCHEN, M.D.Lithium carbonate in patients with small cell lung cancer receiving combination chemotherapyLithium and the mitogenic response of human lymphocytesLithium Carbonate in the Treatment of Drug-Induced Leukopenia in Patients with Solid TumorsThe effect of lithium carbonate on leukopenia after chemotherapyIncreased Granulocyte Adherence in Psoriasis and Psoriatic ArthritisThe effect of lithium carbonate on lymphocyte, granulocyte, and platelet functionLithium Treatment of Cyclic Hematopoiesis in the Gray CollieLithium and Granulocytopenia During Induction Therapy of Acute Myelogenous Leukemia: Update of an Ongoing TrialThe Effect of Lithium Carbonate Administration in Patients with Advanced Small Cell Bronchogenic Carcinoma Receiving Combination Chemotherapy and RadiotherapyHigher Leukocyte Nadirs with Lithium Carbonate After ChemotherapyPrevention by Using Lithium Carbonate of Neutropenia Due to AntiblasticsLithium Therapy of Chronic NeutropeniaGranulocyte Function in Patients Receiving Lithium CarbonateOral Lithium Carbonate Increases Colony Stimulating Activity Production from Human Mononuclear CellsInfection in the Compromised Host 1 June 1978Volume 88, Issue 6Page: 809-810KeywordsBone marrowCancer chemotherapyCarbonatesFelty syndromeGranulocytesNeutropenia Issue Published: 1 June 1978 PDF DownloadLoading ...