tbuckley/cabot-search huggingface dataset:
Foreign Body in Lung for 31 Years
Authors: J. Lewin
Journal: BMJ (1945)

preferable to lethane because one treatment properly carried out should cure every case.This substance will not, however, be avail- able till after the war.Lethane will cure a large proportion of cases with one application, but two treatments at a week's interval will give certain cure.In order to obtain good results the details of the application of lethane should be carefully observed.Two or three teaspoonfuls of the oil are used for one treatment.The hair is parted, and 2 or 3 drops from the teaspoon or pipette are dripped on to the scalp.This is repeated in from 12 to 20 different areas all over the scalp.With the finger-tips the scalp is vigorously rubbed for two minutes to ensure equal distribution of the oil.Any oil which trickles down the forehead or behind the ears should be wiped off with cotton-wool and vaseline applied.The following substances proved ineffective in the treatment of pediculosis: 20% solution of dettol, derbac soap, concentrated infusion of quassia, 12.5% formalin soap mixture (M.O.H. Memo.,
Pathophysiology of post-gastrectomy hypoglycaemia
Authors: C. D. Holdsworth, D. Turner, N. McIntyre
Journal: BMJ (1969)

The blood glucose and plasma insulin response to oral glucose and slow intravenous infusion of glucose was determined in seven patients who had undergone partial gastrectomy or gastroenterostomy. Similar studies were conducted in normal subjects; in these experiments oral glucose administration was replaced by infusion of glucose direct into the jejunum in order to simulate the rapid gastric emptying which occurs after gastric surgery.Peak insulin levels were much higher after oral or intrajejunal glucose, though peak blood glucose levels were higher after intravenous glucose. Despite the high insulin levels occurring with oral administration the late fall in blood glucose below fasting levels was not significantly greater after oral or intrajejunal glucose than after intravenous administration of the sugar. This does not support the concept that hyperinsulinaemia alone is responsible for reactive hypoglycaemia.
License of Physicians Practicing in Two States.
Authors: J. V. Stevens
Journal: JAMA (1906)

Jefferson, Wis., July 30, 1906. <h3>To the Editor:</h3> —I wish to thank you for the thoughtful courtesy which prompted you to ask me to use your columns to present the medical examiners' side of the question regarding licensure as applied to those who are practicing in cities situated near to state boundary lines. There are some earnest, honorable men who seem to think that medical examining boards are likely to be very unjust and arbitrary in their action in such cases. We are always willing to answer any questions that are asked concerning our work and glad to have this opportunity to place the matter before your readers in its proper light, as the paragraph on page 2007 ofThe Journal, June 30, 1906, is based on erroneous information. We have recently issued six licenses to as many physicians, all of whom reside in Stillwater, Minn., and who have been
The Quiet Epidemic
Authors: Huan J. Chang, Matthew H. Liang
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TREATMENT OF ANAL FISTULA.Read in the Section on Surgery and Anatomy at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: GEORGE B. SOMERS
Journal: JAMA (1894)

In a very interesting article, occurring in the<i>New York Medical Journal</i>, on the history of anal fistula, Bodenhamer shows that this disease was well known and well treated in very ancient times. He says, in fact, that the ancients "possessed all the indications in the treatment of this disease, as well as the numerous measures and methods of putting them into execution. They had incision and excision with the bistoury; they had the ligature: and they also had cauterization in all its many forms; indeed, we are indebted to them for almost all we know upon the subject of anal fistula." In the absence then of any particularly new ideas concerning this subject, there would appear to be no sufficient reason for taking it up. But in the face of the frequent failures attending its treatment, we are often driven to examine the subject afresh, in order to reassure
No pretending not to know
Authors: R. Rokey
Journal: JAMA (1989)

To the Editor.—  Regarding the article No Pretending Not to Know, 1 we feel that Dr Brown, as a consultant, has made an error in judgment by revealing unfavorable diagnostic and prognostic information to a patient who directly asked him the results of an examination that he had just performed. He defends his revelation as justifiable because to do otherwise and lie would be improper, and it was what any physician would have done. We would not have done so.  Dr Brown obviously is aware of the traditional arguments against such revelations because he enumerates them by admitting that he is not the patient's primary physician, not familiar with all the details of her case, not knowledgeable of almost any of the events leading to his contact with her, and not aware of who, if anyone, will discuss the results and implications of this test with her. He feels that
Dummies and SIDS: Causality has not been established
Authors: Peter S Blair, Peter J Fleming
Journal: BMJ (2006)

Editor—The relative risk for associated factors should not be confused with the attributable risk for causative factors. Li et al express the risk associated with sudden infant death syndrome (SIDS) and use of a dummy (pacifier) during sleep as a 90% reduction in risk, which could be potentially misunderstood and brings unwarranted media attention to what otherwise …
Charities say UK government must do more to help soldiers returning from battle
Authors: Owen Dyer
Journal: BMJ (2007)

Survival of UK patients after cancer is improving but still lags behind the European average, despite the United Kingdom spending more than other countries on cancer, different sources of data published this week show.Figures from the Office for National Statistics (ONS) show that between 1999 and 2004 survival rates for most cancers in England improved.However, two studies published in Lancet Oncology (
971 ASSEMBLY OF COMPLEX I OF THE MITOCHONDRIAL RESPIRATORY CHAIN IN MURINE NON-ALCOHOLIC FATTY LIVER DISEASE AND EFFECTS OF ROSIGLITAZONE THERAPY
Authors: I. García-Ruiz, C. Rodríguez-Juan, T. Díaz-Sanjuán, D. Fernández-Moreira, P. Solis-Muñoz, T. Muñoz-Yagüe, J.A. Solís-Herruzo
Journal: Journal of Hepatology (2008)
Prospective study of ultrasonography in chronic pancreatic disease.
Authors: W R Lees, A G Vallon, M E Denyer, S P Vahl, P B Cotton
Journal: BMJ (1979)

Grey-scale ultrasonography was used in 212 unselected patients in whom the presence or absence of pancreatic disease was subsequently confirmed by other means. Ultrasonographic criteria were established in the first 92 patients and by reference to previous experience. The remaining 120 patients were studied prospectively. The accuracy and clinical impact of the ultrasonographic diagnosis were judged alongside a standard clinical assessment. Clinical diagnoses were tentative and inaccurate. Ultrasound failed in three cases; otherwise it detected all the 33 patients with chronic pancreatic disease and correctly distinguished cancer from chronic pancreatitis. The ultrasonographic diagnosis of a normal pancreas was always correct, but four false-positive diagnoses were made in patients subsequently judged to have no pancreatic disease. Ultrasonography gave more accurate or more confident and accurate information than the clinical assessment in 57 of the 98 patients studied as problems in diagnosis. With this degree of accuracy ultrasonography should be the first imaging investigation in patients suspected of suffering from pancreatic disease. In our gastrointestinal unit the combination of grey-scale ultrasonography with techniques designed to outline the duct systems (such as endoscopic pancreatography) provides precise diagnosis and documentation of pancreatic disease.
On Remembering a Small Boy's Why
Authors: Kevin Hadduck
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Structural analysis of oval-cell-mediated liver regeneration in rats
Authors: Katalin Dezsõ, Veronika Papp, Edina Bugyik, Hargita Hegyesi, Géza Sáfrány, Csaba Bödör, Péter Nagy, Sándor Paku
Journal: Hepatology (2012)

We have analyzed the architectural aspects of progenitor-cell-driven regenerative growth in rat liver by applying the 2-acetaminofluorene/partial hepatectomy experimental model. The regeneration is initiated by the proliferation of so-called oval cells. The oval cells at the proximal tips of the ductules have a more differentiated phenotype and higher proliferative rate. This preferential growth results in the formation of a seemingly random collection of small hepatocytes, called foci. These foci have no clonal origin, but possess a highly organized structure, which shows similarities to normal hepatic parenchyma. Therefore, they can easily remodel into the lobular structure. Eventually, the regenerated liver is constructed by enlarged hepatic lobules; no new lobules are formed during this process. The foci of the Solt-Farber experimental hepatocarcinogenesis model have identical morphological features; accordingly, they also represent only regenerative, not neoplastic, growth.Progenitor-cell-driven liver regeneration is a well-designed, highly organized tissue reaction, and better comprehension of the architectural events may help us to recognize this process and understand its role in physiological and pathological reactions.
Osteoarthritis of the hip and osteoporosis of the proximal femur.
Authors: C Cooper, P L Cook, C Osmond, L Fisher, M I Cawley
Journal: Annals of the Rheumatic Diseases (1991)

A negative association has been reported between osteoarthritis and osteoporosis. There are, however, few population based data to support this association. In this study the bone density in the upper femur was compared with the presence and severity of hip osteoarthritis in 314 subjects undergoing radiography for non-skeletal indications. There was a statistically significant negative association between the two disorders. This relation may reflect differences in the cause of these two major musculoskeletal conditions.
Abstract 4474: Dual inhibitors for PI3K and Erk induce growth inhibition of tumor cells
Authors: Irene Seipelt, Matthias Gerlach, Silke Baasner, Lars Blumenstein, Gilbert Mueller, Babette Aicher, Eckhard Guenther, Michael Teifel
Journal: Cancer Research (2010)

Abstract The Ras/Raf/Mek/Erk and the PI3K-Akt signaling pathways are prime targets for drug discovery in proliferative diseases such as cancer. The results of research to date indicate that both the MAPK and the PI3K signaling pathways represent therapeutic intervention points for the clinical treatment of malignant tumors. Our multi-parameter optimization program for kinase inhibitor selectivity, cellular efficacy, physico-chemical and in-vitro ADMET properties has led to the identification of a small molecular compound class with an uniquely advantageous dual kinase inhibition profile. These ATP competitive compounds inhibit Erk and PI3K in the nanomolar range and exert high selectivity against other serine threonine and tyrosine kinases. The anti-tumor efficacy of these dual kinase inhibitors was evaluated in diverse human tumor cell lines like HCT116, A549, MDA-MB 468, PC-3 and others. Physicochemical and in-vitro ADMET and safety parameters have been widely assessed. Furthermore in-vivo pharmacokinetic experiments showed plasma profiles expected to result in beneficial in-vivo anti-tumor efficacy. Here we present the key characteristics of the compound class that led to the selection of AEZS-132 for in-vivo experiments with tumor bearing nude mice. The optimization of ADME and physicochemical properties such as solubility, permeability and metabolic stability by medicinal chemistry is ongoing. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4474.
The Future of the Academic Medical Center under Health Care Reform
Authors: D Blumenthal, G S Meyer
Journal: New England Journal of Medicine (1993)

In times of fundamental social change, institutions face both mortal threats and unparalleled opportunities. Such is now the case with the unique class of health care organizations known as academic medical centers.For the purposes of this discussion, we take these organizations to consist of the roughly 120 to 380 institutions (depending on one's precise definition)1,2 that carry out the three missions of teaching, research, and patient care and do so in close affiliation with or as part of a degree-granting university. Imminent reforms in health care promise to accelerate trends that have made the discharge of the traditional . . .
Abstract 1286: Pharmacodynamics of oral curcumin in plasma and rectal mucosa in a Phase IIa trial
Authors: Madhuri Kakarala, Robert E. Carroll, Kim Turgeon, Melissa Tuck, Richard V. Benya, Frank Meyskens, Dean Brenner
Journal: Cancer Research (2011)

Abstract Background: Curcumin, a dietary polyphenol derivative of turmeric, has potent cancer reductive activity in in vivo colon carcinogenesis models. We administered curcumin at doses of 2 g or 4 g to separate groups of 20 healthy human smokers with &amp;gt; 8 aberrant crypt foci (ACF). The 2 g dose showed no ACF reduction while the 4 g dose showed a 46% reduction (p&amp;lt;0.005) We analyzed native curcumin and its conjutes in matched plasma and rectal mucosa biopsy sample from 21 participants at 2g and 18 participants at 4g. Methods: Curcuminoid products were extracted from homogenized biopsy tissue and ultacentrifuged plasma and evaporated under argon. The separation was performed on a Symmetry® C18 column. The mobile phase used under gradient conditions was 25% acetonitrile with 74.9% containing 0.1% acetic acid (25:74.9:0.1; v/v/v; A) and 100% acetonitrile containing 0.1% acetic acid (99.9:0.1; v/v; B) The flow rate was 0.3 mL/min and injection volume for all samples was 10 µL. The lower limit of detection for curcumin from human plasma was 5 ng/mL and from human colonic mucosa was 50 ng/5mg tissue. Results: See Table below (summarized by pre and post treatment dose for plasma and mucosal concentrations) Conclusions: Native curcumin is not detectable in the majority of biopsy and plasma samples. Conjugated curcumin is detectable in all plasma samples and the majority of mucosal biopsies with a significant increase in plasma concentrations at 4g. We postulate the conjugates detected in the rectal mucosa are delivered systemically from absorption and conjugation higher in the gastrointestinal tract and may have biologic activity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1286. doi:10.1158/1538-7445.AM2011-1286
Ischemic Pain in Aortic Regurgitation
Authors: Satoshi Saito, Madhava J. Naik, Stephen Westaby
Journal: Circulation (2001)

A 53-year-old man presented with acute retrosternal chest pain and electrocardiographic changes sufficient to warrant thrombolysis with tissue plasminogen activator (TPA).When he developed pulmonary edema and signs of severe aortic regurgitation, a clinical diagnosis of acute aortic dissection was considered.Transesophageal echocardiography ruled this out but showed aortic root dilatation with free aortic regurgitation.Left ventricular enlargement suggested a chronic process.A spiral computer tomographic (CT) scan confirmed the echocardiographic findings (Fig
Public opinion on different approaches to teaching intubation techniques.
Authors: G Brattebo, T Wisborg, K Solheim, N Oyen
Journal: BMJ (1993)

Clinical characteristics, risk factors, and haematological profiles ofpatients with myocardial infarction and ofhealthy controls.Values are means (SD) unless stated otherwise Patients with: Normal coronary Stenosed or arteries occluded artery Healthy controls (n=12) (n-I1) (n-lI) Age (years) 40 (6)* 58 (9)** 37 (8) No ofmen X2=4-1, df=4, p-0.40
The interaction of 2,3-diphosphoglycerate with various human hemoglobins
Authors: H. Franklin Bunn, Robin W. Briehl
Journal: Journal of Clinical Investigation (1970)

Oxygen equilibria were measured on a number of human hemoglobins, which had been "stripped" of organic phosphates and isolated by column chromatography. In the presence of 2 x 10(-4) M 2,3-diphosphoglycerate (2,3-DPG), the P(50) of hemoglobins A, A(2), S, and C increased about twofold, signifying a substantial and equal decrease in oxygen affinity. Furthermore, hemoglobins Chesapeake and M(Milwaukee-1) which have intrinsically high and low oxygen affinities, respectively, also showed a twofold increase in P(50) in the presence of 2 x 10(-4) M 2,3-DPG. In comparison to these, hemoglobins A(IC) and F were less reactive with 2,3-DPG while hemoglobin F(I) showed virtually no reactivity. The N-terminal amino of each beta-chain of hemoglobin A(IC) is linked to a hexose. In hemoglobin F(I) the N-terminal amino of each gamma-chain is acetylated. These results suggest that the N-terminal amino groups of the non-alpha-chains are involved in the binding of 2,3-DPG to hemoglobin.
Experimental models of hepatocellular carcinoma
Authors: Philippa Newell, Augusto Villanueva, Scott L. Friedman, Kazuhiko Koike, Josep M. Llovet
Journal: Journal of Hepatology (2008)

Hepatocellular carcinoma (HCC) is a common and deadly cancer whose pathogenesis is incompletely understood. Comparative genomic studies from human HCC samples have classified HCCs into different molecular subgroups; yet, the unifying feature of this tumor is its propensity to arise upon a background of inflammation and fibrosis. This review seeks to analyze the available experimental models in HCC research and to correlate data from human populations with them in order to consolidate our efforts to date, as it is increasingly clear that different models will be required to mimic different subclasses of the neoplasm. These models will be instrumental in the evaluation of compounds targeting specific molecular pathways in future preclinical studies. Hepatocellular carcinoma (HCC) is a common and deadly cancer whose pathogenesis is incompletely understood. Comparative genomic studies from human HCC samples have classified HCCs into different molecular subgroups; yet, the unifying feature of this tumor is its propensity to arise upon a background of inflammation and fibrosis. This review seeks to analyze the available experimental models in HCC research and to correlate data from human populations with them in order to consolidate our efforts to date, as it is increasingly clear that different models will be required to mimic different subclasses of the neoplasm. These models will be instrumental in the evaluation of compounds targeting specific molecular pathways in future preclinical studies.
PLASMA LIPOIDS IN MENTAL DEPRESSION
Authors: David Slight, C. N. H. Long, Ruth W. Salter
Journal: American Journal of Psychiatry (1933)

This study indicates that a comparison of psychotic depressions of the manic-depressive group with normals shows in the former: 1. The total fatty acids of the plasma are higher in the fasting state; also that after a fat meal there is a greater rise in the total fatty acids than in normal subjects. 2. The cholesterol is at a higher level, both in the fasting state and after a fat meal. (See discussion.) 3. The iodine number is lower in the depressives which can be taken to indicate that in these cases there is a greater proportion of saturated plasma lipoids. In conclusion we have to thank Dr. C. A. Porteous and Dr. E. C. Menzies of Verdun Protestant Hospital for the privilege of using some case material under their care.