tbuckley/cabot-search huggingface dataset:
Bone Scintigraphy and Densitometry in Children With Osteopetrosis
Authors: MAHMOUD EL-DESOUKI, ABDULLAH AL HERBISH, SOUD AL RASHEED, NASIR Al JURAYYAN
Journal: Clinical Nuclear Medicine (1995)

Bone scintigraphy and dual x-ray absorptiometry were performed in 18 children (8 males, 10 females) with clinical and radiologic diagnoses of osteopetrosis in order to demonstrate the scintigraphic features of this rare disorder and to measure the bone mineral density. Their mean age was 9 years (range, 3-16 years). Bone scintigraphy demonstrated characteristic features of a widened metaphysis of all long bones that showed increased tracer uptake, particularly in the distal femur and proximal tibia. Dual x-ray absorptiometry of the lumbar spine, three femoral sites, and total body showed a marked increase in bone mineral density. The mean values for bone density of the lumbar spine and greater trochanter were markedly elevated than were other sites. Compared with a normal group matched for age and gender, the increase in bone mineral density was 181% for the lumbar spine and 193% for the greater trochanter. The authors concluded that bone imaging and bone densitometry are useful in establishing the diagnosis of osteopetrosis by demonstrating increase tracer uptake in the widened metaphysis and increased bone density. Bone densitometry may be of prognostic value in follow-up, especially in monitoring the response to therapy.
Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach
Authors: F. Späh
Journal: British Journal of Dermatology (2008)

Journal Article Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach Get access F. Späh F. Späh HELIOS Klinikum Krefeld, Medizinische Klinik I, Lutherplatz 40, D‐47805 Krefeld, Germany Correspondence: Friedhelm Späh. Tel: +49 2151 32 2703 Fax: +49 2151 32 2073 E‐mail: friedhelm.spaeh@helios‐kliniken.de; dr.spaeh@klinikum‐krefeld.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue s2, 1 September 2008, Pages 10–17, https://doi.org/10.1111/j.1365-2133.2008.08780.x Published: 01 September 2008
Abstract 4618: Elucidating the role of distinct glutaminase isoforms in cancer.
Authors: Bonnie Liu, Kyung Song, Mandy Kwong, Min Gao, Rebecca Hong, Michelle Nannini, Deepak Sampath, Marcia Belvin, David Peterson, Marie Evangelista, Anneleen Daemen, Ron Firestein, Georgia Hatzivassiliou
Journal: Cancer Research (2013)

Abstract Glutaminase is a key enzyme for the conversion of glutamine to glutamate with subsequent use as a fuel in the TCA cycle, glutathione production and protein synthesis. A subset of tumor cells shows preferential dependency on glutamine and glutaminase for cell proliferation and survival, consistent with “metabolic addiction” to this pathway. Between two glutaminase loci in the genome, the gene for kidney-type glutaminase (Gls1) has 2 alternatively spliced products (KGA and GAC), with distinct regulation and expression from liver-type glutaminase (Gls2). Furthermore, based on distinct C-termini and enzymatic properties, it has been proposed that the Gls1 alternatively spliced isoforms (KGA and GAC) may themselves have distinct functions. Our data further elucidates the role of glutaminase in cancer by addressing the following key questions: a) what is the major role of glutaminase in cells most sensitive to its inhibition? b) is GAC interchangeable with KGA in its expression pattern and role in tumor cells? c) how do tumors adapt to glutaminase inhibition? By generating and using a panel of GAC and KGA isoform-selective reagents we show that the two isoforms have distinct patterns of expression and distinct roles in cell proliferation, migration and tumor growth in vivo. In addition, based on metabolomics, functional and complementation assays, we propose a mechanistic basis for tumor cell dependency on glutaminase and the tumor adaptive response to glutaminase inhibition. Our data reveal the basis for the addiction of tumor subsets to glutaminase and elucidate the role of distinct isoforms of kidney-type glutaminase isoforms in cancer. Citation Format: Bonnie Liu, Kyung Song, Mandy Kwong, Min Gao, Rebecca Hong, Michelle Nannini, Deepak Sampath, Marcia Belvin, David Peterson, Marie Evangelista, Anneleen Daemen, Ron Firestein, Georgia Hatzivassiliou. Elucidating the role of distinct glutaminase isoforms in cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4618. doi:10.1158/1538-7445.AM2013-4618
Role of farnesoid X receptor and bile acids in alcoholic liver disease
Authors: Sharon Manley, Wenxing Ding
Journal: Acta Pharmaceutica Sinica B (2015)

Alcoholic liver disease (ALD) is one of the major causes of liver morbidity and mortality worldwide. Chronic alcohol consumption leads to development of liver pathogenesis encompassing steatosis, inflammation, fibrosis, cirrhosis, and in extreme cases, hepatocellular carcinoma. Moreover, ALD may also associate with cholestasis. Emerging evidence now suggests that farnesoid X receptor (FXR) and bile acids also play important roles in ALD. In this review, we discuss the effects of alcohol consumption on FXR, bile acids and gut microbiome as well as their impacts on ALD. Moreover, we summarize the findings on FXR, FoxO3a (forkhead box-containing protein class O3a) and PPARα (peroxisome proliferator-activated receptor alpha) in regulation of autophagy-related gene transcription program and liver injury in response to alcohol exposure.
Relationship Between A1C and Glucose Levels in the General Dutch Population
Authors: Esther van 't Riet, Marjan Alssema, Josina M. Rijkelijkhuizen, Piet J. Kostense, Giel Nijpels, Jacqueline M. Dekker
Journal: Diabetes Care (2009)

To investigate the relationship among A1C, fasting plasma glucose (FPG), and 2-h postload plasma glucose in the Dutch general population and to evaluate the results of using A1C for screening and diagnosis of diabetes.In 2006-2007, 2,753 participants of the New Hoorn Study, aged 40-65 years, who were randomly selected from the population of Hoorn, the Netherlands, underwent an oral glucose tolerance test (OGTT). Glucose status (normal glucose metabolism [NGM], intermediate hyperglycemia, newly diagnosed diabetes, and known diabetes) was defined by the 2006 World Health Organization criteria. Spearman correlations were used to investigate the agreement between markers of hyperglycemia, and a receiver operating characteristic (ROC) curve was calculated to evaluate the use of A1C to identify newly diagnosed diabetes.In the total population, the correlations between fasting plasma glucose and A1C and between 2-h postload plasma glucose and A1C were 0.46 and 0.33, respectively. In patients with known diabetes, these correlations were 0.71 and 0.79. An A1C level of > or =5.8%, representing 12% of the population, had the highest combination of sensitivity (72%) and specificity (91%) for identifying newly diagnosed diabetes. This cutoff point would identify 72% of the patients with newly diagnosed diabetes and include 30% of the individuals with intermediate hyperglycemia.In patients with known diabetes, correlations between glucose and A1C are strong; however, moderate correlations were found in the general population. In addition, based on the diagnostic properties of A1C defined by ROC curve analysis, the advantage of A1C compared with OGTT for the diagnosis of diabetes is limited.
Development and validation of the Urticaria Control Test: A patient-reported outcome instrument for assessing urticaria control
Authors: Karsten Weller, Adriane Groffik, Martin K. Church, Tomasz Hawro, Karoline Krause, Martin Metz, Peter Martus, Thomas B. Casale, Petra Staubach, Marcus Maurer
Journal: Journal of Allergy and Clinical Immunology (2014)
Fighting against viral hepatitis: Lessons from Taiwan
Authors: Ding-Shinn Chen
Journal: Hepatology (2011)

Viral hepatitis and its sequelae are important health problems worldwide, including Taiwan. For the last 40 years, Taiwan's scientists and health care providers have worked hard to control these sequelae, and the results have been excellent. The author, Ding-Shinn Chen, had a key role in planning and establishing the control program in Taiwan, and participated in the endeavors from the very beginning. In this perspective, he describes how he became interested in research as a medical student, his encounters with hepatitis B and C, how he and his colleagues started early detection of hepatocellular carcinoma (HCC), how he helped Taiwan's government create and implement the Viral Hepatitis Control Program, and how the effectiveness of the program in the decrease of hepatitis B carriage and HCC was monitored. He also discusses how he pioneered the use of interferon-α plus ribavirin to treat chronic hepatitis C. Hepatitis B viral load as a risk factor for HCC and cirrhosis in hepatitis B surface antigen carriers is reviewed briefly, as is the prevention of sequelae by antiviral therapies. Finally, Dr. Chen discusses unresolved issues that must be addressed and predicts the changes of the patterns of liver disease in Taiwan beyond the mid-21st century, which is in part affected by the fight against viral hepatitis that was initiated in the early 1980s. Conclusion : Dr. Chen's perspective illustrates Taiwan's fight against viral hepatitis over the last 40 years. This experience can be shared by other countries in which the disease is equally prevalent. (Hepatology 2011;)
<i>Cardiobacterium valvarum</i> Endocarditis
Authors: Xiang Han
Journal: Annals of Internal Medicine (2005)

Letters18 October 2005Cardiobacterium valvarum EndocarditisXiang Han, MD, PhDXiang Han, MD, PhDFrom M.D. Anderson Cancer Center, University of Texas, Houston, TX 77030.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-8-200510180-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their letter on endocarditis due to a novel Cardiobacterium species, I believe that Hoover and colleagues (1) described the second case of Cardiobacterium valvarum endocarditis. The first case, along with the isolation and establishment of the novel species C. valvarum, was reported in April 2004 (2), and the species name was validated in the same year (3). This case of insidious endocarditis was not diagnosed until sudden rupture of a cerebral aneurysm. Headache, aphasia, and the stigmata of aortic valve endocarditis (diastolic heart murmur, anemia, and leukocytosis) were initial diagnostic features in this 37-year-old man. The ...References1. Hoover SE, Fischer SH, Shaffer R, Steinberg BM, Lucey DR. Endocarditis due to a novel Cardiobacterium species [Letter]. Ann Intern Med. 2005;142:229-30. [PMID: 15684222] LinkGoogle Scholar2. Han XY, Meltzer MC, Woods JT, Fainstein V. Endocarditis with ruptured cerebral aneurysm caused by Cardiobacterium valvarum sp. nov. J Clin Microbiol. 2004;42:1590-5. [PMID: 15071009] CrossrefMedlineGoogle Scholar3. Euzéby J. Validation of publication of new names and new combinations previously effectively published outside the IJSEM. Int J Syst Evol Microbiol. 2004;54:1425-6. [PMID: 15879221] CrossrefMedlineGoogle Scholar4. Han XY, Falsen E. Characterization of oral strains of Cardiobacterium valvarum and emended description of the organism. J Clin Microbiol. 2005;43:2370-4. [PMID: 15872268] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From M.D. Anderson Cancer Center, University of Texas, Houston, TX 77030.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEndocarditis Due to a Novel Cardiobacterium Species Susan E. Hoover , Steven H. Fischer , Rebecca Shaffer , Bryan M. Steinberg , and Daniel R. Lucey Metrics Cited ByCardiobacterium valvarum infective endocarditis and phenotypic/molecular characterization of 11 Cardiobacterium species strainsAntidepressiva 18 October 2005Volume 143, Issue 8Page: 614KeywordsAortic valveConflicts of interestEndocarditisFeversGene sequencingHeadachesLeukocytosisMouthPhylogenetic analysis ePublished: 18 October 2005 Issue Published: 18 October 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Clinical Use of Radionuclide Bone Imaging in a University Medical Center
Authors: Stephan D. Fihn, Eric B. Larson, Thomas R. Rudd, Wil B. Nelp
Journal: JAMA (1982)

To assess the diagnostic utility of radionuclide bone imaging, we reviewed all examinations performed during a two-year period in a university medical center. The indication(s) for each bone image and its interpretation were compared by reviewing requisition forms and medical records. Thirty-nine percent of 988 studies demonstrated relevant abnormalities. Yields of pertinent positive findings were greatest in patients with cancers of the breast (40%) and prostate (38%) and lowest in women with uterine cancer (15%), patients with previously normal bone images, and individuals with suspected but unconfirmed malignancy. Incidental findings, unrelated to the indication for imaging, occurred frequently (up to 41% of cases). We did not find a sizable number of negative studies that could readily be labeled as unnecessary, suggesting that bone imaging is generally a useful procedure as applied by physicians in this setting. (<i>JAMA</i>1982;248:439-442)
Wheat grain immunofluorescent antibodies as an indication of gluten sensitivity?
Authors: KIRSTI KALIMO, EEVA VAINIO
Journal: British Journal of Dermatology (1980)

Journal Article Wheat grain immunofluorescent antibodies as an indication of gluten sensitivity? Get access KIRSTI KALIMO, KIRSTI KALIMO Department of Dermatology, University of Turku, 20520 Turku 52, Finland Search for other works by this author on: Oxford Academic Google Scholar EEVA VAINIO EEVA VAINIO Department of Dermatology, University of Turku, 20520 Turku 52, Finland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 103, Issue 6, 1 December 1980, Pages 657–662, https://doi.org/10.1111/j.1365-2133.1980.tb01688.x Published: 01 December 1980
Enucleation of human erythroblasts involves non-muscle myosin IIB
Authors: Kumi Ubukawa, Yong-Mei Guo, Masayuki Takahashi, Makoto Hirokawa, Yoshihiro Michishita, Miho Nara, Hiroyuki Tagawa, Naoto Takahashi, Atsushi Komatsuda, Wataru Nunomura, Yuichi Takakuwa, Kenichi Sawada
Journal: Blood (2011)
The Predictive Value of Rodent Carcinogenicity Tests in the Evaluation of Human Risks
Authors: L Tomatis
Journal: The Annual Review of Pharmacology and Toxicology (1979)

In the last fifteen years various authors have estimated that from about 70% to 90% of all human cancer cases can be attributed to environmental causes (4, 19, 20, 61). These percentages were based on two main considerations: (a) a certain number of environmental factors have been identified in the etiology of human cancer, and (b) significant variations in the incidence of cancer in different population groups in different countries suggest that environmental risk factors play an important role. The variation in different countries in the incidence of cancers that occur at the most common target organs fluctuates betweeen fourfold and more than one hundredfold (10, 19). It was therefore proposed that the lowest observed incidence rates could be taken as a baseline and that any increase over this baseline could be attributed to environmental factors, of which only a few so far have been identified. Ignoring, or disregarding, such considerations, it has been simplistically inferred that 90% of all cancer cases could now be prevented; this is certainly not what the above-men­ tioned authors meant to imply. The euphoria so engendered has not yet been dispelled, despite the words of caution that some authors have tried to interject, in an attempt to define environment and the role of environmen­ tal factors (21). An assessment of the number of cancers that could, in fact, be prevented would obviously be of paramount importance; however, it would be difficult
Phase II Study of Gemcitabine and Cisplatin in Patients with Previously Untreated Extensive Stage Small Cell Lung Cancer: Southwest Oncology Group Study 9718
Authors: Paul J. Hesketh, Kari Chansky, Valerie Israel, Richard T. Grapski, Tarek M. Mekhail, C Harris Spiridonidis, Glenn M. Mills, Karen Kelly, John J. Crowley, David R. Gandara
Journal: Journal of Thoracic Oncology (2007)
Clonal architecture of chronic myelomonocytic leukemias
Authors: Raphaël Itzykson, Olivier Kosmider, Aline Renneville, Margot Morabito, Claude Preudhomme, Céline Berthon, Lionel Adès, Pierre Fenaux, Uwe Platzbecker, Olivier Gagey, Philippe Rameau, Guillaume Meurice, Cédric Oréar, François Delhommeau, Olivier A. Bernard, Michaela Fontenay, William Vainchenker, Nathalie Droin, Eric Solary
Journal: Blood (2013)
Pulmonary Artery Catheterization: Developing Guidelines
Authors: Michael F. Roizen
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Regarding the article entitled "Pulmonary Artery Catheterization: Can There Be an Integrated Strategy for Guideline Development and Research Promotion?" by Naylor et al,<sup>1</sup>the American Society of Anesthesiologists (ASA) has just completed guideline development, including setting a research agenda for indications, risks, and benefits, of pulmonary artery catheterization. This process was guided by a methodologist (Steven H. Woolf, MD, MPH), was sponsored by the ASA, had outside reviewers, including experts in the field, organizational reviewers (American College of Cardiology, American College of Physicians, and American College of Surgeons), and was sent to the Society for Critical Care Medicine (whose review came in too late for their comments to be included). This guideline and literature summary have been published in<i>Anesthesiology</i><sup>2</sup>after review in open forums and by the house of delegates of the ASA. The research agenda that was set is a major part of
Spontaneous Reduction of an Incarcerated Acute Diaphragmatic Hernia
Authors: I. Nik Nevin
Journal: JAMA (1963)

SPONTANEOUS REDUCTION of an acute strangulated diaphragmatic hernia must occur only rarely, for no such documented case heretofore has been recorded. <h3>Report of a Case</h3> A 46-year-old widow was admitted to the hospital on June 23, 1960, with the chief complaint of inability to swallow anything for 1 week. She also felt a lumpy and painful sensation over the substernal region. Her history revealed that she had had several similar "attacks" since 1957; but on each of the previous occasions the vomiting and pain disappeared after 2 or 3 days. These "attacks" were described by the patient as a feeling of a lump in the throat and inability to eat or drink anything without initiating severe vomiting. Between these attacks she was asymptomatic. Physical examination revealed an obese woman in acute distress. The main symptoms were persistent substernal pain and continuous retching. The vital signs were: BP 160/88 mm Hg,
Treatment With Adjuvant Endocrine Therapy for Early-Stage Breast Cancer: Is It Forever?
Authors: Beth Overmoyer
Journal: Journal of Clinical Oncology (2015)

Article Tools ONCOLOGY GRAND ROUNDS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2014.58.2361 Journal of Clinical Oncology - published online before print January 26, 2015 PMID: 25624431 Treatment With Adjuvant Endocrine Therapy for Early-Stage Breast Cancer: Is It Forever? Beth OvermoyerxBeth OvermoyerSearch for articles by this author Show More Dana-Farber Cancer Institute, Boston, MA https://doi.org/10.1200/JCO.2014.58.2361 First Page Full Text PDF Figures and Tables © 2015 by American Society of Clinical Oncology
DEVELOPMENT OF ULTRASOUND RESPONSIVE THROMBUS-TARGETING DRUG DELIVERY SYSTEM FOR CORONARY THROMBOLYSIS
Authors: Hiroyuki Kawata, Tsunenari Soeda, Yasuhiro Takemoto, Ji-Hee Sung, Yoshiko Uesugi, Yasuhiko Tabata, Keiji Kato, Kenichi Ishigami, Manabu Horii, Shiro Uemura, Yoshihiko Saito
Journal: Journal of the American College of Cardiology (2012)
A new biological marker for depression?
Authors: Elizabeth Rasche González
Journal: JAMA (1983)

The standard for diagnosis of depression in the United States is the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-III). To ascertain which DSM criteria patients meet and to assess their symptoms, psychiatrists often rely on psychodiagnostic instruments such as the Beck Depression Inventory, the Zung Self-Rating Depression Scale, the Hamilton Depression Rating Scale, and the Schedule for Affective Disorders and Schizophrenia. Unfortunately, clinicians cannot yet base diagnoses on the results of objectively assessed physiological abnormalities (other than superficially observable phenomena, such as anorexia, psychomotor retardation, and early morning waking in some types of depression). Hence the quest for definitive biological "marker systems" continues. Perhaps the best-known system at present is the dexamethasone suppression test. On this assay, exogenous dexamethasone administration fails to suppress endogenous cortisol secretion in many different disease states, including some depressions. Another is the urinary assay for the major norepinephrine metabolite, 3-methoxy-4-hydroxyphenylglycol. Others
The lexicon from a neurophysiological view
Authors: Horst M. M&uuml;ller
Journal: Behavioral and Brain Sciences (1999)

(1) Reaction time (RT) studies give only a partial picture of language processing, hence it may be risky to use the output of the computational model to inspire neurophysiological investigations instead of seeking further neurophysiological data to adjust the RT based theory. (2) There is neurophysiological evidence for differences in the cortical representation of different word categories; this could be integrated into a future version of the Levelt model. (3) EEG/MEG coherence analysis allows the monitoring of synchronous electrical activity in large groups of neurons in the cortex; this is especially interesting for activation based network models.
Consultants at Alder Hey look to the future
Authors: D. A Hughes
Journal: BMJ (2001)

EDITOR—During the past two years the issue of organ retention has placed Alder Hey Children's Hospital under a political and media spotlight. The chief medical officer's report on retained organs clearly identified longstanding practices that were widespread and well recognised by the medical profession.1 The early revelation at the Bristol inquiry about heart collections, and subsequent discoveries in our own trust, led to an independent inquiry and intense media attention.2 We are proud that all staff continued to provide the highest standards of care to the children and their parents while facing the difficult issues uncovered in the course of the inquiry. The trust has accepted the report of the independent inquiry and replied to its recommendations. Consultant members of our medical board have apologised for the …