tbuckley/cabot-search huggingface dataset:
Reflections on "Playing God"
Authors: Christine K. Cassel
Journal: Annals of Internal Medicine (1992)

Editorials15 January 1992Reflections on "Playing God"Christine K. Cassel, MDChristine K. Cassel, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-2-163 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe stories by Michael LaCombe are always compelling and evocative. He is a gifted master of the story teller's art and an increasingly recognized and accomplished author. He is also a physician, and his stories are grounded in the concrete realities of people's lives and their struggles with human frailty, both physical and emotional. "Playing God," the story in this issue ofAnnals, is a clear example of all these attributes of his work (1). LaCombe's unpretentious and poetic prose puts the reader in the middle of that clear winter night, so clear that "...you had trouble believing there could...References1. LaCombe M. Playing God. Ann Intern Med. 1992;116:161-2. LinkGoogle Scholar2. Brody H. Stories of Sickness. New Haven: Yale University Press; 1989;171-81. Google Scholar3. Hunter K. Doctors' Stories: The Narrative Structure of Medical Knowledge. Princeton, New Jersey: Princeton University Press; 1991. CrossrefGoogle Scholar4. JonsenToulmin AS. The abuse of casuistry. Berkeley. University of Chicago Press; 1988. Google Scholar5. Tronto J. Beyond gender difference to a theory of care. Signs: Journal of Women in Culture and Society. 1987;12:644-63. CrossrefGoogle Scholar6. FosterVealeFogel LCC. Factors present when battered women kill. Issues Ment Health Nurs. 1989;10:273-84. CrossrefMedlineGoogle Scholar7. BullockMcFarlaneBatemanMiller LJLV. The prevalence and characteristics of battered women in a primary care setting. Nurse Pract. 1989;14:47, 50, 53-6. CrossrefMedlineGoogle Scholar8. BergmanBrismar BB. Battered wives—measures by the social and medical services. Postgrad Med J. 1990;66:28-33. CrossrefMedlineGoogle Scholar9. McLeerAnwarHermanMaquiling SRSK. Education is not enough; a systems failure in protecting battered women. Ann Emerg Med. 1989;18:651-3. CrossrefMedlineGoogle Scholar10. BrendtroBowker ML. Battered women: how can nurses help? Issues Ment Health Nurs. 1989;10:169-80. CrossrefMedlineGoogle Scholar11. Frazer M. Domestic violence: a medicolegal review. J Forensic Sci. 1986:31:1409-19. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPlaying God—RevisitedDaniel C. Citron, MD 15 January 1992Volume 116, Issue 2Page: 163-164KeywordsEmotionsFrailty Issue Published: 15 January 1992 PDF DownloadLoading ...
The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.
Authors: B P Giroir, J H Johnson, T Brown, G L Allen, B Beutler
Journal: Journal of Clinical Investigation (1992)

Tumor necrosis factor (TNF) is a protein hormone implicated in the development of septic shock and other pathologic states. However, complexities inherent in detecting TNF synthesis by individual tissues have left the precise origins of this protein undefined. In addition, the possibility that localized TNF production may contribute to the pathogenesis of organ-specific diseases such as type I diabetes has not been explored in vivo. We have developed a transgenic mouse line bearing a reporter gene construct in which the TNF coding sequence and introns are replaced by a chloramphenicol acetyltransferase (CAT) coding sequence. In normal transgenic animals, CAT activity is expressed only in the thymus. When endotoxin is administered to the animals, CAT activity is also evident in kidney, heart, islets of Langerhans, spleen, lung, fallopian tubes, and uterus, but not in other organs. The biosynthesis of CAT in vivo correlated with tissue capacity to secrete TNF in vitro. Thus, TNF was secreted by all the tissues that expressed CAT, including lung, spleen, thymus, uterus/fallopian tubes, pancreatic islets, renal glomeruli, and cultured cardiac cells after exposure to endotoxin.
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high density lipoproteins
Authors: Kaare R. Norum, John A. Glomset, Alex V. Nichols, Trudy Forte
Journal: Journal of Clinical Investigation (1971)

LOW DENSITY LIPOPROTEINS (LDL) AND HIGH DENSITY LIPOPROTEINS (HDL) FROM THE PLASMA OF PATIENTS WITH FAMILIAL LECITHIN: cholesterol acyltransferase (LCAT) deficiency have been characterized by gel filtration, analytical ultracentrifugation, and gel electrophoresis, and their relative content of lipid and protein has been determined. The LDL of d 1.019-1.063 g/ml show marked heterogeneity. A subfraction of the LDL emerges from columns of 2% agarose gel with the void volume, has corrected flotation rates (S(f) degrees ) in the range of 20-400, and contains 4-10 times as much unesterified cholesterol, phosphatidylcholine, and triglyceride per mg protein as normal LDL. A major subfraction of the LDL emerges from the gel in the same general position as normal LDL, but exhibits somewhat higher flotation rates and contains 1.5-3 times as much unesterified cholesterol and phosphatidylcholine and 13 times as much triglyceride per mg protein. The HDL, shown to be heterogeneous in earlier studies, are mainly comprised of molecules which have flotation rates of F(1.20) 3-20, migrate in the alpha(1)-alpha(2) region on electrophoresis, and contain about 12 times as much unesterified cholesterol and 5 times as much phosphatidylcholine per mg protein as normal HDL. Smaller molecules are also detected, which have flotation rates of F(1.20) 0-3, migrate in the prealbumin region on electrophoresis, and contain only slightly more unesterified cholesterol and phosphatidylcholine per mg protein than normal HDL.
Laboratory controlled trials are different from clinical trials
Authors: J. A. Betts
Journal: BMJ (2012)

Heneghan and colleagues deemed many highly regarded studies to be of low quality and at high risk of bias.1 It is therefore essential to consider whether they used appropriate criteria to evaluate studies. Their method to determine risk of bias is more commonly used to evaluate clinical trials so it places heavy emphasis on controlling for deciphering treatment or group allocation, blinding, and thus avoidance of demand characteristics or placebo …
Cerebral herniation during bacterial meningitis in children.
Authors: G Rennick, F Shann, J de Campo
Journal: BMJ (1993)

To see whether the incidence of cerebral herniation is increased immediately after lumbar puncture in children with bacterial meningitis and whether any children with herniation have normal results on cranial computed tomography.Retrospective review of case notes; computed tomograms were read again.Large paediatric teaching hospital.445 children over 30 days old admitted to hospital with bacterial meningitis.Timing of herniation in relation to lumbar puncture; findings on computed tomography in children with herniation.Cerebral herniation was detected in 19 (4.3%) of the 445 children (21 episodes; herniation occurred twice in two children). Herniation occurred in 14 (45%) of the 31 children who died. Nineteen episodes of herniation occurred in the 17 children who had a lumbar puncture; 12 of the episodes occurred in the first 12 hours after the lumbar puncture and seven over six other 12 hour periods (odds ratio 32.6 (95% confidence interval 8.5 to 117.3); p < 0.001). The results of cranial computed tomography were normal in five (36%) of the 14 episodes of herniation in which scanning was performed at about the time of herniation.The temporal relation between lumbar puncture and herniation strongly suggests that a lumbar puncture may cause herniation in some patients, and normal results on computed tomography do not mean that it is safe to do a lumbar puncture in a child with bacterial meningitis.
The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings
Authors: Cemal Yazici, Laura Yanoso, Chao Xie, David G. Reynolds, R. Jude Samulski, Jade Samulski, Judith Yannariello-Brown, Arthur A. Gertzman, Xinping Zhang, Hani A. Awad, Edward M. Schwarz
Journal: Biomaterials (2008)
Influence of Angiotensin on the Hemodynamic Response to Exercise in Normotensive Subjects
Authors: RUNE SANNERSTEDT, ED VARNAUSKAS
Journal: Circulation (1968)

The effect of exercise on the systemic hemodynamic response in 11 healthy men has been studied before and during an intravenous infusion of angiotensin sufficient to increase the resting mean arterial blood pressure an average of 29%. On exercise in the angiotensin period there was a significantly smaller rise of the systolic pressure than on exercise in the control state, and the response of the diastolic pressure was changed from a moderate increase to a decrease on an average. The increase in mean arterial pressure on exercise was almost abolished, being 4.3 mm Hg during the infusion compared with 20.6 mm Hg before infusion. The rise in cardiac output on exercise was significantly smaller during the angiotensin period, while at the same time there were no significant changes in the behavior of the heart rate, stroke volume, or systemic vascular resistance. The findings indicate that the vasoconstricting effects of angiotensin are largely overcome by the vasodilating effect of exercise in the working muscle groups, but the possibility of relatively increased vasoconstriction in the vascular bed supplying less vitally important tissues is pointed out.
The World of Surgery, 1945-1985: Memoirs of One Participant
Authors: Claude E. Welch
Journal: JAMA (1987)

It is fortunate that Professor James Hardy has published his edited memoirs, for his life exemplifies many of the important developments in American surgery in the last 40 years. Few persons could duplicate this dual task in which biographical notes illustrate contemporary events, since most surgeons are only vaguely cognizant of the kaleidoscopic changes that have affected medicine in this period. Dr Hardy has succeeded in his career and in this project for several reasons. He never shunned hard work, he had an overwhelming desire to excel in all of his endeavors, and he maintained an uncompromising approach to many problems that allowed him to solve them expeditiously in manners that were ultimately proved to be correct. He has been in the vanguard of many recent advances, such as the surgical therapy of ductless glands and organ transplantation. Because he kept numerous files and was a faithful diarist, he was
Effects of Acetylcholine on Regional Pulmonary Blood Flow in Patients with Mitral Stenosis
Authors: JON B. GLAZIER, COLIN T. DOLLERY, JOHN M. B. HUGHES
Journal: Circulation (1968)

The effect of acetylcholine was studied on the region of increased vascular resistance at the lung bases in patients with mitral stenosis. The patients had moderate elevations of pulmonary artery pressure. The distribution of blood flow and ventilation were measured in both lungs of 10 patients using radioactive xenon-133 and a scanning technique. Acetylcholine was then infused into one main pulmonary artery, and the distribution of blood flow and ventilation were measured again. One lung served as a control during the drug infusion. There was a small but significant increase in perfusion to the dependent lung zone during the drug infusion without a change in pulmonary artery pressure indicating localized vasodilation. Relative underperfusion was still present during the acetylcholine administration which indicated that increased vasomotor tone was not the principal pathophysiological mechanism for the increased vascular resistance. There was a decrease in ventilation to the lower zone of the lung receiving acetylcholine.
Cytochrome P450 1B1–Mediated Estrogen Metabolism Results in Estrogen-Deoxyribonucleoside Adduct Formation
Authors: Alexandra R. Belous, David L. Hachey, Sheila Dawling, Nady Roodi, Fritz F. Parl
Journal: Cancer Research (2007)

Abstract The oxidative metabolism of estrogens has been implicated in the development of breast cancer; yet, relatively little is known about the mechanism by which estrogens cause DNA damage and thereby initiate mammary carcinogenesis. To determine how the metabolism of the parent hormone 17β-estradiol (E2) leads to the formation of DNA adducts, we used the recombinant, purified phase I enzyme, cytochrome P450 1B1 (CYP1B1), which is expressed in breast tissue, to oxidize E2 in the presence of 2′-deoxyguanosine or 2′-deoxyadenosine. We used both gas and liquid chromatography with tandem mass spectrometry to measure E2, the 2- and 4-catechol estrogens (2-OHE2, 4-OHE2), and the depurinating adducts 4-OHE2-1(α,β)-N7-guanine (4-OHE2-N7-Gua) and 4-OHE2-1(α,β)-N3-adenine (4-OHE2-N3-Ade). CYP1B1 oxidized E2 to the catechol 4-OHE2 and the labile quinone 4-hydroxyestradiol-quinone to produce 4-OHE2-N7-Gua and 4-OHE2-N3-Ade in a time- and concentration-dependent manner. Because the reactive quinones were produced as part of the CYP1B1-mediated oxidation reaction, the adduct formation followed Michaelis-Menten kinetics. Under the conditions of the assay, the 4-OHE2-N7-Gua adduct (Km, 4.6 ± 0.7 μmol/L; kcat, 45 ± 1.6/h) was produced 1.5 times more efficiently than the 4-OHE2-N3-Ade adduct (Km, 4.6 ± 1.0 μmol/L; kcat, 30 ± 1.5/h). The production of adducts was two to three orders of magnitude lower than the 4-OHE2 production. The results present direct proof of CYP1B1-mediated, E2-induced adduct formation and provide the experimental basis for future studies of estrogen carcinogenesis. [Cancer Res 2007;67(2):812–7]
The other hard problem: How to bridge the gap between symbolic and subsymbolic cognition
Authors: Axel Cleeremans
Journal: Behavioral and Brain Sciences (1998)

The constructivist notion that features are purely functional is incompatible with the classical computational metaphor of mind. I suggest that the discontent expressed by Schyns, Goldstone &amp; Thibaut about fixed-features theories of categorization reflects the growing impact of connectionism. Their perspective is similar to recent research on implicit learning, consciousness, and development. A hard problem remains, however: how to bridge the gap between subsymbolic and symbolic cognition.
Clearance of pentosidine, an advanced glycation end product, by different modalities of renal replacement therapy
Authors: Toshio Miyata, Yasuhiko Ueda, Atsuhiro Yoshida, Satashi Sugiyama, Yoshiyasu Iida, Michel Jadoul, Kenji Maeda, Kiyoshi Kurokawa, Charles van Ypersele de Strihou
Journal: Kidney International (1997)
Decades of Work to Reduce Disparities in Health Care Produce Limited Success
Authors: Rebecca Voelker
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Telemetry Glucose Monitoring Device With Needle-Type Glucose Sensor: A Useful Tool for Blood Glucose Monitoring in Diabetic Individuals
Authors: Motoaki Shichiri, Nobuyuki Asakawa, Yoshimitsu Yamasaki, Ryuzo Kawamori, Hiroshi Abe
Journal: Diabetes Care (1986)

For continuous monitoring of glucose concentration in ambulant diabetic patients, a telemetry glucose monitoring system with a needle-type glucose sensor has been developed. The system consists of a sensor transmitter (4 X 6 X 2 cm, 50 g) that converts current signals generated in a needle-type glucose sensor to high-frequency audio signals and a receiver that continuously calculates glucose concentrations from the received audio signals. The noise range of a monitoring record with the telemetry system (0.3 +/- 0.04%, mean +/- SEM) was significantly smaller than that with a wire-connected system, the wearable artificial endocrine pancreas (2.5 +/- 0.3%). Postprandial tissue glucose concentration responded well to the plasma glucose concentration, with a time lag of 5 min. Continuous glucose monitoring of five diabetic subjects for 77 +/- 22 h revealed that a significant correlation existed between the subcutaneous tissue glucose concentration and the plasma glucose concentration measured simultaneously in each patient. These data indicate the usefulness of the telemetry glucose monitoring system in strict glycemic control of diabetic individuals.
Modest Reductions in Dose Intensity and Drug-Induced Neutropenia have No Major Impact on Survival of Patients with Non-small Cell Lung Cancer Treated with Platinum-Doublet Chemotherapy
Authors: Andre T. Brunetto, Craig P. Carden, James Myerson, Ana Luisa Faria, Sue Ashley, Sanjay Popat, Mary E.R. O'Brien
Journal: Journal of Thoracic Oncology (2010)
Accreditation of Allied Health Education
Authors: John J. Fauser
Journal: JAMA (1992)

IN RECENT years, educational, regulatory, and political groups have targeted effectiveness as a primary goal in American postsecondary education. This has given rise to a number of national initiatives during the past 18 months that may have a major influence on the future course of allied health education and accreditation. Three projects are of marked significance: (1) the outcomes analysis project of the Council on Postsecondary Accreditation (COPA)-Fund for Improvement of Postsecondary Education (FIPSE), (2) the report of the Pew Health Professions Commission, and (3) the reauthorization of the Higher Education Act of 1965. Each in its own way stresses the importance of evaluating results in assessing educational quality, a concept long supported by the American Medical Association Committee on Allied Health Education and Accreditation (CAHEA). <h3>COPA-FIPSE OUTCOMES ANALYSIS PROJECT</h3> The outcomes analysis project conducted by COPA, with support from FIPSE's Project on Accreditation for Educational Effectiveness: Assessment Tools for
384 Natural history of chronic HBV infection: A cohort study with five years follow-up in North Greece. Part of the interreg I–II EC-project
Authors: S. Kotsiou, G.H. Zacharakis, J. Koskinas, M. Papoutselis, F. Tzara, N. Vafeiadis, E. Pouliou, K. Papoutselis
Journal: Journal of Hepatology (2004)
Scintigraphic Flare in Skeletal Lymphoma
Authors: L M. WHITE, B. G. GRAY, M. ICHISE, J. C. KIRSH, R. BURKES
Journal: Clinical Nuclear Medicine (1994)

The authors describe the bone scan flare phenomenon in a patient with treated skeletal lymphoma. This was confirmed by both gallium scanning and computed tomography. If serial bone scintigraphy is used for assessing the treatment response of lymphoma, the flare phenomenon must be recognized.
Points: Further developments in psychogeriatrics in Britain
Authors: J M A Smithies
Journal: BMJ (1985)

ments committees, grant awarding bodies, etc, are more impressed by the quantity than by the quality of published work.Unfortunately, the medical profession can- not seek guidance in proper behaviour from the scientific community, whose morals are questioned because of duplication and fraud.2Among so called pure scientists the ethic of "publish or perish" seems even more revered.Only when it is agreed that scientific communications are intended to further knowledge, rather than careers or egos, will we reach the peak of the present, senseless, exponential
Amniotic fluid cell morphology in early antenatal prediction of abortion and low birth weight.
Authors: C Gosden, D J Brock
Journal: BMJ (1978)

The morphology of rapidly adherent (RA) amniotic fluid cells was examined in 201 pregnant women referred for amniocentesis because of two sequential high serum alpha-fetoprotein (AFP) concentrations. Out of 43 amniotic fluid samples containing increased amounts of AFP, 42 had neural or peritoneal cells predominating among the RA cells, the outcome being an infant with a neural-tube defect or exomphalos. In the other case with a raised amniotic fluid AFP concentration but only anterior placental cells the infant was normal. In 25 amniotic fluid samples containing normal amounts of AFP distinctive new patterns of RA cells were observed, termed fetal distress cells. These pregnancies resulted in five spontaneous abortions and 20 infants with birth weights under 2500 g. Fetal distress cells were not detected in any of the remaining 133 samples. One pregnancy was terminated because of a chromosomal abnormality, and there were seven twin pairs not recognised on ultrasonography before amniocentesis. The remaining 125 pregnancies went to term, resulting in infants with birth weights exceeding 2500 g. The results suggest that RA-cell morphology will prove to be of value in the early antenatal prediction of spontaneous abortion and low birth weight.
Abstract 5008: The acetylenic tricyclic bis(cyanoeneone), TBE-31 inhibits non-small cell lung cancer cell migration through direct binding with actin
Authors: Eddie Chan, Akira Saito, Tadashi Honda, John D. Guglielmo
Journal: Cancer Research (2014)

Abstract During metastasis tumor cells undergo epithelial to mesenchymal transition (EMT), where cell-cell junctions dissolve and actin stress fibers are formed. This transition unmasks the migratory and invasive potential of the tumor cells. Here we show that the tricyclic compound TBE-31 binds to purified actin as well as actin from cell lysates. Furthermore, TBE-31 inhibits linear and branched actin polymerization in vitro as well as stress fiber formation in fibroblasts. We also observed that TBE-31 inhibits stress fiber formation in non-small lung cancer cells during TGFβ-dependent EMT. Interestingly, TBE-31 does not interfere with TGFβ-dependent signaling or changes in E- and N-cadherin protein levels during EMT. Finally, we observed that TBE-31 inhibits non-small cell lung tumor cell migration. Our results suggest that TBE-31 targets linear actin polymerization to alter cell morphology and inhibit cell migration. Citation Format: Eddie Chan, Akira Saito, Tadashi Honda, John Di Guglielmo. The acetylenic tricyclic bis(cyanoeneone), TBE-31 inhibits non-small cell lung cancer cell migration through direct binding with actin. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5008. doi:10.1158/1538-7445.AM2014-5008