Gastrointestinal Carcinoma and Concomitant Hypoglycemia
Authors: FRANCISCO M. GONZALEZ
Journal: Annals of Internal Medicine (1963)

Case Studies1 January 1963Gastrointestinal Carcinoma and Concomitant HypoglycemiaFRANCISCO M. GONZALEZ, M.D., G. LENNARD GOLD, M.D., BRUCE I. SHNIDER, M.D., F.A.C.P.FRANCISCO M. GONZALEZ, M.D.Search for more papers by this author, G. LENNARD GOLD, M.D.Search for more papers by this author, BRUCE I. SHNIDER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-149 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of spontaneous hypoglycemia in association with large non-pancreatic tumors has been described in the medical literature by several investigators (1, 2). This type of hypoglycemia is indistinguishable from the organic variety that accompanies islet cell tumors of the pancreas or severe hypo-adrenalism (3). The tumors reported have been of mesenchymal origin and sarcomatous in type. Also, adrenocortical carcinomas have been known to occasionally produce a lowering of blood sugar values (3), but these neoplasms, too, originate from mesodermal tissue. Reports appearing in the past (4-7) have conveyed the impression that hypoglycemia is exclusively a function of tumors of...References1. PORTERFRANTZ MEVK: A tumor associated with hypoglycemia-pancreatic and extrapancreatic. Amer. J. Med. 21: 944, 1956. CrossrefMedlineGoogle Scholar2. LOWBEER L: Hypoglycemia-producing extrapancreatic neoplasms: a review. Amer. J. Clin. Path. 35: 233, 1961. CrossrefMedlineGoogle Scholar3. CONNSELTZER JWHS: Spontaneous hypoglycemia. Amer. J. Med. 19: 460, 1955. CrossrefMedlineGoogle Scholar4. MILLERBOLLINGERJANIGANCROCKETTFRIESEN DRREDJESR: Hypoglycemia due to non-pancreatic mesodermal tumors: report of two cases. Ann. Surg. 150: 684, 1959. CrossrefMedlineGoogle Scholar5. KLEINKLEIN HSP: Spontaneous hypoglycemia associated with massive hepatoma. Arch. Intern. Med. 103: 273, 1959. CrossrefGoogle Scholar6. NESBITTBOSWELLDEJESUS-GONZALEZSARKISIAN KAJTMASS: Malignant mesothelioma associated with hypoglycemia: report of a case. Amer. J. Clin. Path. 30: 148, 1958. CrossrefMedlineGoogle Scholar7. NEVIUSFRIEDMAN DBNB: Mesotheliomas and extra ovarian thecomas with hypoglycemia and nephrotic syndrome. Cancer 12: 1263, 1959. CrossrefMedlineGoogle Scholar8. VALLANCE-OWENHURLOCKPLEASE JBNW: Plasma insulin activity in diabetes mellitus. Lancet 2: 583, 1955. CrossrefGoogle Scholar9. TRANQUADABEIGELMANBENDER REPMAB: Carcinoma of the cecum associated with hypoglycemia. Clin. Res. 9: 64, 1961. Google Scholar10. MCNAUGHTONPRIEST MDEA: Hypoglycemia associated with retroperitoneal leiomyosarcoma. Lancet 1: 204, 1960. CrossrefMedlineGoogle Scholar11. AUGUSTHIATT JTHH: Severe hypoglycemia secondary to a non-pancreatic fibrosarcoma with insulin activity. New Engl. J. Med. 258: 17, 1958. CrossrefMedlineGoogle Scholar12. WRENSHALLBOGOCHRITCHIE GAARC: Extractable insulin of pancreas: correlation with pathologic and clinical findings in diabetic and non-diabetic cases. Diabetes 1: 87, 1952. CrossrefMedlineGoogle Scholar13. WILLEBRANDSGELDGROWN ASHVJ: Determination of serum insulin using the isolated rat diaphragm. Diabetes 7: 119, 1958. CrossrefMedlineGoogle Scholar14. WHITNEYMASSEY JECG: Apparent insulin activity in a fibrosarcoma associated with spontaneous hypoglycemia. J. Clin. Endocr. 21: 541, 1961. CrossrefGoogle Scholar15. SILVERSTEINWAKIMBAHNBAYRD MNKGRCED: A hypoglycemic factor in leukemic tumors. Proc. Soc. Exp. Biol. Med. 103: 824, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRANCISCO M. GONZALEZ, M.D.; G. LENNARD GOLD, M.D.; BRUCE I. SHNIDER, M.D., F.A.C.P.Affiliations: Washington, D. C.From the Georgetown Medical Division, District of Columbia General Hospital, and the Department of Medicine, Georgetown University School of Medicine.This study was supported in part by research grant CYP 2824 from the National Cancer Institute.Requests for reprints should be addressed to Bruce I. Shnider, M.D., Georgetown Medical Division, District of Columbia General Hospital, Washington 3, D. C. 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LIPSETT, M.D., F.A.C.P., WILLIAM D. ODELL, M.D., LEON E. ROSENBERG, M.D., THOMAS A. WALDMANN, M.D.Hypoglycemia associated with neoplasiaPsychiatry and General MedicineEndocrine Dysfunction in Malignant Disease 1 January 1963Volume 58, Issue 1Page: 149-154KeywordsArthritisBlood sugarCecumHospital medicineHypoglycemiaInsulinMetabolic disordersPancreasPathology and laboratory medicineResearch grants ePublished: 1 December 2008 Issue Published: 1 January 1963 PDF downloadLoading ...