Comparison of Philadelphia Chromosome-Positive and -Negative Patients with Chronic Myelocytic Leukemia
Authors: STEPHEN KRAUSS
Journal: Annals of Internal Medicine (1964)

Article1 October 1964Comparison of Philadelphia Chromosome-Positive and -Negative Patients with Chronic Myelocytic LeukemiaSTEPHEN KRAUSS, M.D., JOSEPH E. SOKAL, M.D., AVERY A. SANDBERG, M.D.STEPHEN KRAUSS, M.D.Search for more papers by this author, JOSEPH E. SOKAL, M.D.Search for more papers by this author, AVERY A. SANDBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-625 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiscovery of the Philadelphia chromosome (Ph1) in cases of chronic myelocytic leukemia (1) provided the first demonstration of a specific chromosomal abnormality in a human neoplasm. However, this abnormal cytogenetic feature is not present in all cases of this disorder, and a small number of patients said to be typical otherwise, but lacking the Ph1chromosome, have been described (2). Since 1961, cytogenetic studies have formed part of the initial and subsequent hematologic investigation of patients with chronic myelocytic leukemia seen at this Institute. During this time, we have observed and treated both Ph1+and Ph1-patients. The contrasts between...References1. NOWELLHUNGERFORD PCDA: Chromosome studies in human leukemia. II. Chronic granulocytic leukemia. J. Nat. Cancer Inst. 27: 1013, 1961. MedlineGoogle Scholar2. COURT-BROWNTOUGH WMIM: Cytogenetic studies in chronic myeloid leukemia, in Advances in Cancer Research 7, Academic Press Inc., New York and London, 1963, p. 351. Google Scholar3. SANDBERGISHIHARACROSSWHITEHAUSCHKA AATLHTS: Comparison of chromosome constitution in chronic myelocytic leukemia and other myeloproliferative disorders. Blood 20: 393, 1962. CrossrefMedlineGoogle Scholar4. KAPLOW LS: A histochemical procedure for localizing and evaluating leukocyte alkaline phosphatase activity in smears of blood and marrow. Blood 10: 1023, 1955. 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DAMESHEK W: Some speculations on the myeloproliferative syndrome (editorial), Blood 6: 372, 1951. CrossrefMedlineGoogle Scholar12. TRUJILLAOHNO JMS: Chromosomal alterations of erythropoietic cells in chronic myeloid leukemia. Acta Haemat. (Basel) 29: 311, 1963. CrossrefMedlineGoogle Scholar13. NAKAICRADDOCKFIGUEROA GSCGWG: Agnogenic myeloid metaplasia: a survey of 29 cases and a review of the literature. Ann. Intern. Med. 57: 419, 1962. LinkGoogle Scholar14. GUNZHOUGH FWRF Acute leukemia over the age of fifty: a study of its incidence and natural history. Blood 11: 882, 1956. CrossrefMedlineGoogle Scholar15. MITUSBERGNAMEDNICOFFDAMESHEK WJLJIBW: Alkaline phosphatase of mature neutrophils in chronic forms of the myeloproliferative syndrome. Amer. J. Clin. Path. 30: 285, 1958. CrossrefMedlineGoogle Scholar16. HAYHOE FG Leukaemia: Research and Clinical Practise. Little, Brown, and Co., Boston, 1960, p. 88. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Buffalo, New YorkFrom the Division of Medicine, Roswell Park Memorial Inst., New York State Department of Health, Buffalo, N. Y.This work was supported in part by grant T4 CA 5076, National Cancer Institute, U. S. Public Health Service, Bethesda, Md., and by grant T-182 from the American Cancer Society.Requests for reprints should be addressed to Stephen Krauss, M.D., Roswell Park Memorial Institute, 666 Elm St., Buffalo, N. Y. 14203. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClinical use of SNP-microarrays for the detection of genome-wide changes in haematological malignanciesCurrent Clinical Practice: Management of the Chronic Leukemias: Special Considerations in the Elderly Patient. Part III. 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Cytogenetic experience in Ph1-negative chronic myelocytic leukemia (CML)Chronic myelogenous leukemiaBlastic transformation in chronic myelogenous leukemia: Experience with 50 patientsDie chronische myeloische LeukämieDifferent Composition of the Eosinophilic Bone Marrow Pool in Reactive Eosinophilia and Eosinophilic Leukaemia?Chronic myelogenous? leukemia of juvenile typeDiagnostic and Therapeutic Approach to Chronic LeukaemiaVerschiedene, Ph1-positive und Ph1-negative cytogenetische Stammlinien bei myelomonocyt�rem Proliferationssyndrom im fr�hen KindesalterIsochromosome 17 in a Case of Eosinophilic LeukaemiaPatho-anatomical features of so-called Ph1? chronic myeloid leukemiaCytogenetic Analysis in LeukemiaHeterogeneity of Ph1 in chronic myeloid leukaemiaChromosomal Changes in Human Tumors and LeukemiasParoxysmal Nocturnal Haemoglobinuria and Chronic Myeloid Leukaemia in the Same PatientThe Spectrum of Myeloproliferative DisordersLEUKÆMIA AND ALLIED DISORDERS 1. CONCEPTS, DEFINITIONS AND CLASSIFICATIONSAnomalies of the Small Acrocentric (chromosomes in Human Tumour Cells*Unfavorable Signs in Patients with Chronic Myelocytic LeukemiaATHANASIOS THEOLOGIDES, M.D., Ph.D., F.A.C.P.BIBLIOGRAPHYDas Philadelphia ChromosomThe myeloproliferative disordersMuramidase Studies in Philadelphia-Chromosome-Positive and Chromosome-Negative Chronic Granulocytic LeukemiaChromosomal Analysis in Clinical MedicinePhiladelphia-Chromosome-Positive and -Negative Chronic Myelocytic LeukemiaE. Z. EZDINLI, M.D., J. E. SOKAL, M.D., F.A.C.P., L. CROSSWHITE, B.S., A. A. SANDBERG, M.D.Polyglobulie und Polycythaemia veraRecent advances in molecular pathology: A reviewCHROMOSOMES IN HAEMATOLOGYLEUKOCYTE ALKALINE PHOSPHATASE CYTOCHEMISTRY: APPLICATIONS AND METHODSTHE PHILADELPHIA CHROMOSOME AND LEUKOCYTE ALKALINE PHOSPHATASE IN CHRONIC MYELOCYTIC LEUKEMIA AND RELATED DISORDERSLEUKOCYTE ALKALINE PHOSPHATASE IN CHRONIC GRANULOCYTIC LEUKEMIA OF CHILDHOODLEUKOCYTE ALKALINE PHOSPHATASE CYTOCHEMISTRY: APPLICATIONS AND METHODSTHE PHILADELPHIA CHROMOSOME AND LEUKOCYTE ALKALINE PHOSPHATASE IN CHRONIC MYELOCYTIC LEUKEMIA AND RELATED DISORDERSLEUKOCYTE ALKALINE PHOSPHATASE IN CHRONIC GRANULOCYTIC LEUKEMIA OF CHILDHOODA Chromosomal Theory of CarcinogenesisJEAN DE GROUCHY, M.D., CRISTINA DE NAVA, M.D.Chromosomentranslokation bei chronisch-myeloproliferativem SyndromChronic myelocytic leukemia in infantsiblingsPhiladelphia-Chromosom und alkalische Leukocyten-Phosphatase bei chronischer MyeloseCHROMOSOMES IN EFFUSIONSATYPICAL Ph1 CHROMOSOME BY PERICENTRIC INVERSIONDouble Ph1 chromosomes in chronic granulocytic leukemiaHypodiploid chromosome pattern in acute leukemia following polycythemia veraEtude clinique et cytogénétique de 21 patients atteints de leucémie myéloïde chroniqueObservations on the in vitro Growth of Peripheral Leucocytes from Patients with Myeloproliferative DisordersChronic myelocytic leukemia with features simulating myelofibrosis with myeloid metaplasiaChronic Neutrophilic LeukemiaHARRY RUBIN, M.D.Case 28-1966Chromosome abnormalities in human cancer. Report of a patient with chronic myelocytic leukemia and his nonleukemic monozygotic twinPhiladelphia Chromosome Abnormality in Agnogenic Myeloid MetaplasiaRALPH H. FORRESTER, JOSE M. LOURODoppel-Philadelphia-Chromosom und Isochromosom 17 in der terminalen Phase der chronischen myeloischen LeukämieDOUBLE Ph1 CHROMOSOMES IN LEUKÆMIAMATERNAL HYPERVENTILATION AND THE FŒTUSVAGITUS UTERINUSChromosome Changes in the Terminal Stages of Chronic Granulocytic LeukaemiaChromosomenuntersuchungen bei chronisch-myeloischer LeukämiePhiladelphia chromosome in eosinophilic leukemiaGIANT-SATELLITED CHROMOSOME IN MARFAN'S SYNDROMEX-RAYS AND PHILADELPHIA CHROMOSOMEGUANOXAN IN HYPERTENSIONBETA-RECEPTOR BLOCKADE IN THE DIAGNOSIS OF PHÆOCHROMOCYTOMAEOSINOPHILIC LEUKÆMIA WITH Ph1-POSITIVE CELLS 1 October 1964Volume 61, Issue 4Page: 625-635KeywordsChromosomal diseasesChromosomesChronic myelocytic leukemiaCytogeneticsMedical services Issue Published: 1 October 1964 PDF DownloadLoading ...