Hydroxyproline and Collagen Metabolism: Clinical Implications: Combined Clinical Staff Conference at the National Institutes of Health
Authors: ALBERT SJOERDSMA
Journal: Annals of Internal Medicine (1965)

Clinical Staff Conference1 October 1965Hydroxyproline and Collagen MetabolismCombined Clinical Staff Conference at the National Institutes of HealthALBERT SJOERDSMA, M.D., PH.D., SIDNEY UDENFRIEND, PH.D., HARRY KEISER, M.D., E. CARWILE LEROY, M.D.ALBERT SJOERDSMA, M.D., PH.D.Search for more papers by this author, SIDNEY UDENFRIEND, PH.D.Search for more papers by this author, HARRY KEISER, M.D.Search for more papers by this author, E. CARWILE LEROY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-4-672 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Albert Sjoerdsma: Collagen is one of the scleroproteins and accounts for about 30% of the body proteins. It exerts an architectural function throughout the body, most notably in skin, tendons, cartilage, blood vessels, connective tissue, organ capsules, and bone matrix. It confers the ultimate in "togetherness" and, except in psychiatry, is responsible for making one an "intact" individual. It is of fundamental importance in the pathogenesis of various diseases, in the processes of growth and aging, and of course in the healing of wounds. Use of the term "collagen disease" in clinical medicine has served at least as a...References1. SCHMITT FO: Giant molecules in cells and tissues. Sci. Amer. 197: 204, 1957. CrossrefGoogle Scholar2. GROSS J: Collagen. Sci. Amer. 204: 121, 1961. CrossrefMedlineGoogle Scholar3. HARKNESSMARKOMUIRNEUBERGER RDAMHMA: The metabolism of collagen and other proteins of the skin of rabbits. Biochem. J. 56: 558, 1954. CrossrefMedlineGoogle Scholar4. JACKSON DS: Connective tissue growth stimulated by carrageenin. 1. The formation and removal of collagen. Biochem. J. 65: 277, 1957. CrossrefMedlineGoogle Scholar5. STETTEN MR: Some aspects of the metabolism of hydroxyproline, studied with the aid of isotopic nitrogen. J. Biol. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandThis is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Md., by the National Heart Institute, National Institutes of Health, Public Health Service, United States Department of Health, Education, and Welfare.Requests for reprints should be addressed to Albert Sjoerdsma, M.D., Chief, Experimental Therapeutics Branch, National Heart Institute, Bldg. 10, Room 7-N-260, National Institutes of Health, Bethesda, Md. 20014. 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