tbuckley/cabot-search huggingface dataset:
Abstract P5-17-04: Management of Antiangiogenics' Renovascular Safety in breast cancer. Subgroup and intermediate results of the MARS Study.
Authors: V Launay-Vacher, N Janus, C Daniel, J-B Rey, I Ray-Coquard, J Gligorov, J-P Spano, J-C Thery, C Jouannaud, F Goldwasser, O Mir, J-F Morere, S Oudard, M Azizi, R Dorent, G Deray, P Beuzeboc
Journal: Cancer Research (2012)

Abstract Background: Hypertension (HTN) and proteinuria (Pu) are class-side-effects of anti-VEGF drugs (AVD), related to the inhibition of the VEGF pathway. The MARS study has been conducted to assess the renovascular tolerance of these drugs in the clinical setting. Methods: The MARS study is a multicentric prospective observational study of the renovascular safety of AVD in AVD-naive patients. in 7 centres from 2009 to 2011. There was no intervention on the choice of the AVD. Data collected included: gender, age, serum creatinine (SCr), diabetes, HTN, hematuria (Hu) and dipstick Pu. This sub-group analysis presents the intermediate results for the first 184 patients with breast cancer (BC) receiving bevacizumab who completed the 1-year follow-up (f/u) (out of 337 BC patients in total). Results: All these 184 patients received bevacizumab (mean and median durations of treatment: 7.8 and 8 months, respectively). Median age at inclusion was 60 years. Bone, visceral and cerebral metastasis frequencies were 75.0, 52.2 and 7.1%, respectively. Diabetes and HTN prevalences were 4.3% and 10.3%, respectively. Baseline renal assessment retrieved: Pu 13.0%, Hu 8.2%, mean aMDRD 98.8 ml/min/1.73m2 and 1.1% had aMDRD&amp;lt;60. The incidence of de novo Pu during f/u was 16.3% (Table). 58.3% of patients with Pu at inclusion improved. Among patients with de novo Pu, 42.3% afterwards improved/normalized. No grade 3/4 Pu has been reported and no hematuria. 12.7% developed HTN. In addition, renal function decreased by −3.4 ml/min/1.73m2/year and 4 patients had aMDRD&amp;lt;60 at the end of f/u. 33.2% increased their SCr: 27.7% grade 1, 4.9% grade 2, and 0.5% grade 3. All patients with grade 2–3 returned to normal or grade 1 during f/u. No thrombotic micro-angiopathy has been reported. Conclusion: These results show that 1) No thrombotic micro-angiopathy remains rare, 2) Pu developed in 16.3% of patients, with no grade 3/4, 3) less than 13% developed HTN, and 4) renal function was only slightly impaired with transient elevations in SCr. Furthermore, in case of a renovascular effect, investigators followed the recommendations from the French Society of Nephrology (Halimi JM et Al. Nephrol Ther 2008) and no treatment withdrawal for unmanageable renovascular toxicity occurred. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-17-04.
Air-Rifle Wound of the Heart With Embolization
Authors: Adrian J. Neerken, Frederick L. Clement
Journal: JAMA (1964)

A PENETRATING WOUND of the chest with embolization of the missile to a peripheral artery is a rare injury. Spencer and Kennedy reviewed this subject in 1957 and were able to find reports of 24 patients who demonstrated such a lesion, to which they added one of their own.<sup>1</sup>We are aware of one other case which has been reported since that time.<sup>2</sup>An additional example is presented in this communication. <h3>Report of a Case</h3> On the afternoon of June 27, 1963, a 10-year-old boy was brought to a physician's office after having been shot in the chest with an air rifle from a distance of about ten feet. He was pale, faint, and complained of difficulty in breathing. A small wound was present just lateral to the sternal border in the left fourth intercostal space. No wound of exit was found. Heart tones were distant and the
Alcohol-Related Deaths of American Indians-Reply
Authors: Carol Chiago Lujan
Journal: JAMA (1992)

In Reply.  —Dr Gibb's letter suggests that tribal sovereignty is part of the problem rather than part of the solution to alcohol abuse. Gibb's views, unfortunately, reflect a lack of knowledge concerning tribal sovereignty and American Indian governments. Thus, a brief discussion of inherent tribal sovereignty is in order.  American Indian nations and tribes were sovereign, self-governing communities before Europeans came to America, and the US Constitution recognizes the sovereignty of American Indian tribes. 1 Through treaties with the United States, American Indian tribes retained their sovereign rights to self-government, and American Indian reservations were established to provide homelands for American Indian people in the face of the advancing tide of European settlement. 2   Congress unilaterally ended treaty making in 1871, and at the height of the Social Darwinist era in 1887, the Allotment Act was enacted to break up reservations, distribute 160-acre parcels of tribal land to individual American
Sticking with tradition
Authors: Sarah H Oram
Journal: BMJ (2006)

backgrounds and with no family tradition of higher education to design and deliver a successful short term educational opportunity.We have identified what we consider are the critical success factors of such a programme and predict that, if these can be replicated, the summer school should be broadly transferable to other settings.But we have not yet shown a long term impact of this initiative on pupils' identity, confidence, motivation, or action.We are continuing to follow these pupils as they enter the sixth form and begin to construct their applications to medical school, and we hope to publish data at a later stage on their success rates and subsequent progress.We congratulate the pupils who participated in the Dick Whittington project for their enthusiasm and hard work.We thank all participating schools for their engagement and collaboration and Mohammed Lais for help with interviews.The summer school could not have been possible without the positive support and cooperation of the management and staff of the Whittington Hospital Trust and especially the many clinicians who served as guest tutors.We are extremely grateful to our three sponsors who provided funding and active input to the project steering group.
Screen Filtration Pressure of Blood--An Evaluation
Authors: D. P. Dhall, J. Engeset, F. N. McKenzie, N. A. Matheson
Journal: Cardiovascular Research (1969)

The relative importance of some factors in the determination of screen filtration pressure (SFP) of human blood has been examined. The physical determinants of SFP are defined and the effect of time, anticoagulant, red cells, platelets, and leucocytes are established. Changes in SFP correspond closely to the size of platelet aggregates once a size of approximately 50 μ is exceeded.
Hypocalcaemia after intravenous bisphosphonate
Authors: Cameron Fergus
Journal: BMJ (2004)

Editor-The Data Protection Act 1998 does not prohibit the processing of personal information for medical research purposes.Indeed, it is clear from section 33 of the act that such processing is expressly permitted.If it were otherwise, then the act would be in direct conflict with the core aims of the laws that underpin it-namely, the Council of Europe Convention of 1981 and the European Union Directive of 1995.These laws seek to facilitate data processing activities, primarily "free flows" of information, rather than suppress data processing.The problems to which Peto et al refer in their editorial on data protection, informed consent, and research are not Data Protection Act problems but, rather, problems caused by ignorance and misunderstanding. 1 With basic training on the key mechanisms of the act the problems of which the authors complain can be easily overcome.Training need not be an expensive task either.Legal compliance can be achieved at comparatively modest cost.There are two additional points of note.Firstly, the Data Protection Act regulates the processing of personal information relating to living individuals.Thus, research following death is not regulated.Secondly, the act and case law make clear that information will not be "personal data" if it does not identify a living person or if it does not have the individual as its focus or is not significantly biographical.So, if medical researchers do not actually need or seek identification information the act should not be engaged.
The Quantitative Electrokymograph
Authors: RUSSELL H. MORGAN, RALPH E. STURM
Journal: Circulation (1951)

The quantitative electrokymograph has been developed in an effort to provide an instrument which will be easier to operate than the electrokymographic equipment currently available. In addition, provision has been made for the recording of both border-motion phenomena and densitometric changes within the heart and great vessels. In the design of the instrument, considerable attention has been directed toward the development of a means whereby electrokymographic tracings may be calibrated. Care has also been exercised in the instrument's design in order to provide a frequency response that is essentially flat from 0 to 40 cycles per second.
Study Reignites Debate About Viral Agent in Patients With Chronic Fatigue Syndrome
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nutritional state of patients with lung cancer undergoing thoracotomy.
Authors: Y Bashir, T R Graham, A Torrance, G J Gibson, P A Corris
Journal: Thorax (1990)

Preoperative nutritional assessment was carried out on 39 consecutive patients with bronchial carcinoma who underwent thoracotomy. For 18 patients the body mass index and triceps and subscapular skinfold thickness fell below the 25th centile. In 23 patients the creatinine height index was less than 80% of the predicted value. The mean (SEM) serum albumin concentration was 40.3 (0.57) g/l (reference range 35-50 g/l) and mean (SEM) serum transferrin 1.77 (0.1) g/l (reference range 2.0-3.0 g/l). Although only three patients were hypoalbuminaemic, transferrin concentrations were depressed in 26 patients. There was a significant fall in the serum concentrations of both prealbumin and transferrin in the first postoperative week. Nutritional insufficiency was particularly severe in the four patients who developed an early bronchopleural fistula. It is concluded that protein-energy malnutrition is common in patients with operable bronchial carcinoma and that routine postoperative feeding does not prevent further depletion of circulating proteins. A larger prospective study is needed to examine the relation between preoperative nutritional state and outcome.
Stricter rules on prescribing will cut 1.3bn from Spain's deficit
Authors: A. G. Rada
Journal: BMJ (2010)

From next year doctors in Spain will be able to prescribe the exact number of pills of certain drugs, the country’s new health minister has announced. The move will save Spain €300m (£255m; $400m), Leire Pajin told the health commission of the Congress, the parliament’s lower house.

Ms Pajin said that at the moment prepackaging meant that patients often get more pills than they need, causing unnecessary expense and contributing to the risk of self treatment.

The Spanish Agency of Medicines and Health …
SEVERE ERYTHEMA MULTIFORME WITH INTESTINAL INVOLVEMENT
Authors: G. MARSHALL CRAWFORD
Journal: JAMA (1949)

Under various names (severe erythema multiforme, Stevens-Johnson's disease, erythema multiforme exudativum and ectodermosis erosiva pluriorificialis), the literature indicates infrequent involvement of the alimentary canal in the toxic eruption commonly known as erythema multiforme. In 1874 Hebra<sup>1</sup>reported a patient with "erythema gyratum" in whom the autopsy revealed "... in the small bowels similar red circles as on the skin." In 1895, 1900 and 1904, Osler<sup>2</sup>published groups of cases, totaling 29, the disease in which he first described as erythema multiforme. In several of these cases there were signs and symptoms referable to the alimentary canal. However, in 1914 Osler<sup>3</sup>revised his view in an article referring to most of these cases as examples of Henoch's and Schönlein's purpura. Lever<sup>4</sup>and Costello<sup>5</sup>each published reviews and case studies in more recent years. Of Lever's 2 patients, neither had signs or symptoms of lesions in the gastrointestinal
Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity
Authors: Sabina Sangaletti, Claudio Tripodo, Claudia Chiodoni, Carla Guarnotta, Barbara Cappetti, Patrizia Casalini, Silvia Piconese, Mariella Parenza, Cristiana Guiducci, Caterina Vitali, Mario P. Colombo
Journal: Blood (2012)
Alveolar Hydatid Disease
Authors: David J. LaFond
Journal: JAMA (1963)

The parasite Echinococcus multilocularis which causes alveolar hydatid disease is distinct in both larval form and host specificity from the more common E granulosus . Surgical treatment of E multilocularis infestation is usually impossible. The budding alveolar cysts infiltrate the liver diffusely rather than forming a solitary cyst as does E granulosus . A case report of infestation by E multilocularis accompanies a brief review of the ecology of the parasite.
Underrepresentation of Older Adults in Cancer Trials
Authors: Jing Luo, Aaron S. Kesselheim
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Possible Influence of δ-Aminolevulinic Acid Dehydratase Polymorphism and Susceptibility to Renal Toxicity of Lead: A Study of a Vietnamese Population
Authors: Sin Eng Chia, Huijun Zhou, Mei Theng Tham, Eric Yap, Nguyen-Viet Dong, NguyenThi Hong Tu, Kee Seng Chia
Journal: Environmental Health Perspectives (2005)

We examined six newly identified polymorphisms in the delta-aminolevulinic acid dehydratase (ALAD) single-nucleotide polymorphisms (SNPs) to determine if these SNPs could modify the relationship between blood lead (PbB) and some renal parameters. This is a cross-sectional study of 276 lead-exposed workers in Vietnam. All workers were measured for PbB, urinary retinol-binding protein (URBP), urinary alpha1-microglobulin (Ualpha1m), urinary beta2-microglobulin (Ubeta 2m), urinary N-acetyl-beta -d-glucosaminidase (NAG), urinary aminolevulinic acid (ALAU), serum alpha1-microglobulin (Salpha1m), serum beta2-microglobulin (Sbeta 2m), and urinary albumin (Ualb). The six SNPs were Msp and Rsa in exon 4, Rsa39488 in exon 5, HpyIV and HpyCH4 in intron 6, and Sau3A in intron 12. Analysis of covariance (ANCOVA) with interaction of PbB times SNPs were applied to examine modifying effect of the SNPs on the association of renal parameters and PbB, adjusting for potential confounders of age, gender, body mass index, and exposure duration. HpyCH4 was found to be associated with certain renal parameters. For HpyCH4 1-1, an increase of 1 microg/dL PbB caused an increase of 1.042 mg/g creatinine (Cr) U alpha1m, 1.069 mg/g Cr Ubeta 2m, 1.038 mg/g Cr URBP, and 1.033 mg/g Cr Ualb, whereas in HpyCH4 1-2, an increase of 1 microg/dL PbB resulted in an increase of only 1.009 mg/g Cr Ualpha1m, 1.012 mg/g Cr Ubeta 2m, 1.009 mg/g Cr URBP, and 1.007 mg/g Cr Ualb. HpyCH4 SNP appeared to modify the lead toxicity to kidney with wild-type allele being more susceptible than variants. The mechanism for this effect is not clear. Further studies are needed to confirm this observation.
Alcohol and the Future of Native Americans
Authors: Kenneth Prager
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The article<sup>1</sup>and Editorial<sup>2</sup>in the March 11, 1992, issue of<i>JAMA</i>regarding alcohol-related deaths of Native Americans brought back vivid memories of my 2 years in the Indian Health Service on the Cheyenne River Sioux Indian Reservation in Eagle Butte, SD. I compiled a list of all deaths on the reservation from July 1,1969, through June 30,1971.<sup>3</sup>The results were depressing: 53% of the deaths were from unnatural causes—motor vehicle accidents, hypothermia, suicides, and drowning. Almost all were alcohol-related. The average age at death of this group was 24 years. Gallaher et al suggest that by legalizing alcohol on their reservations, the Navaho nation might decrease the striking excess mortality from auto accidents and hypothermia by obviating the need for long auto rides by intoxicated Native American men traveling from bars off the reservation back to their homes. In this regard, the Eagle
Angiotensin-Converting Enzyme Inhibition Restores Flow-Dependent and Cold Pressor Test–Induced Dilations in Coronary Arteries of Hypertensive Patients
Authors: Isabelle Antony, Guy Lerebours, Alain Nitenberg
Journal: Circulation (1996)

Cold pressor test (CPT)-induced and flow-dependent epicardial coronary artery dilations are impaired in patients with hypertension. ACE inhibition can attenuate sympathetic coronary constriction and potentiate or restore endothelium-dependent relaxations. This study was designed to determine whether the ACE inhibitor perindoprilat can restore normal coronary dilative responses in hypertensive patients.Coronary vasomotor responses to CPT and to maximal increase of blood flow induced by papaverine were studied in 10 untreated patients with essential hypertension, no other risk factors, and angiographically normal coronary arteries before and after intravenous ACE inhibition by perindoprilat. Diameters of proximal and distal left anterior descending (LAD) and circumflex coronary arteries were measured by quantitative angiography. Estimates of coronary blood flow and resistance index were calculated with an intracoronary Doppler catheter in the distal LAD. Perindoprilat did not modify the hemodynamic responses to CPT and papaverine. In response to CPT, perindoprilat changed the epicardial coronary constriction (-8.4 +/- 5.8%, P < .001) into a significant dilation (+12.0 +/- 6.4%, P < .001). Perindoprilat significantly increased the coronary blood flow (from 33.7 +/- 10.0 to 57.9 +/- 20.5 mL/min, P < .01) and enhanced the decrease in coronary resistance (from 4.28 +/- 1.27 to 2.96 +/- 0.84 mm Hg.mL-1.min-1, P < .001) caused by CPT. Flow-dependent dilation of the proximal LAD was abolished in the control condition and was restored after perindoprilat (12.6 +/- 4.7%, P < .001).ACE inhibition restored CPT-induced and flow-mediated coronary artery dilations in patients with essential hypertension. These results indicate that impaired coronary vasomotor responses may be reversible in recently diagnosed hypertension.
Streptococcus pyogenes and Bone Resorption
Authors: Richard N. Greenberg
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 November 1988Streptococcus pyogenes and Bone ResorptionRichard N. Greenberg, MDRichard N. Greenberg, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-10-843_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:We would like to add several comments to those of Hríbalová (1). Since our case report in 1983, several other investigators have suggested a role forStreptococcus pyogenesas a causative agent for the toxic shock syndrome (2, 3). The possibility that streptococcal pyrogenic exotoxins may have a pathophysiologic role is intriguing, as such a role is often described for staphylococcal toxins in the staphylococcal toxic shock syndrome. We recently isolated a fourth (not previously described) streptococcal pyrogenic exotoxin (SPE-D) from theStreptococcus pyogenesisolated from the patient whose case we previously reported. This strain also produced...References1. Hríbalová V. Streptococcus pyogenes and the toxic shock syndrome. Ann Intern Med. 1988;108:772. LinkGoogle Scholar2. ConeWoodardSchlievertTomory LDPG. Clinical and bacteriologic observations of a toxic shock-like syndrome due to Streptococcus pyogenes. N Engl J Med. 1987;317:146-9. CrossrefMedlineGoogle Scholar3. HoadleySandersSchlievert DCP. Toxic shock-like syndrome due to Streptococcus pyogenes in the setting of soft-tissue infection and bacteremia. Clin Res. 1988;36:20A. Google Scholar4. McMillianBloomsterSaeed RTA. Characterization of a fourth streptococcal pyrogenic exotoxin (SPE-D). FEMS Microbiol Lett. 1987;44:317-22. CrossrefGoogle Scholar5. RaiszNiemann LI. Effect of phosphate, calcium, magnesium on bone resorption, and hormonal responses in tissue culture. Endocrinology. 1969;85:446-56. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis University Medical Center St. Louis, MO 63104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCorrection: Authors of LettersRichard N. Greenberg, MD 15 November 1988Volume 109, Issue 10Page: 843-843KeywordsBone resorptionExotoxinsStreptococcus pyogenesToxic agentsToxic shock syndromeToxins Issue Published: 15 November 1988 PDF DownloadLoading ...
STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMA
Authors: Oscar D. Ratnoff
Journal: The Journal of Experimental Medicine (1948)

1. The experiments reported suggest that the plasma proteolytic enzyme activated by streptococcal fibrinolysin is identical with that activated by chloroform. 2. The precursor of this plasma proteolytic enzyme is precipitated with the euglobulin fraction of plasma at pH 5.2.