tbuckley/cabot-search huggingface dataset:
Effect of Temporal Distribution of Calories on Diurnal Patterns of Glucose Levels and Insulin Secretion in NIDDM
Authors: Christine A Beebe, Eve Van Cauter, E Timothy Shapiro, Hartmut Tillil, Rachel Lyons, Arthur H Rubenstein, Kenneth S Polonsky
Journal: Diabetes Care (1990)

The effect of different temporal patterns of calorie intake on plasma glucose, serum insulin, and insulin secretion rates was examined in six patients with moderately well controlled non-insulin-dependent diabetes mellitus (NIDDM). Patients were studied on three separate occasions over 26 h. Total calories and food composition (50% carbohydrate, 15% protein, and 35% fat) were kept constant, but the pattern of calorie intake was varied. In study A (similar meal size), calories were distributed as 30, 40, and 30% at breakfast, lunch, and dinner, respectively. In study B (3 snacks, 3 meals), each subject ate three meals of 20, 20, and 30% of calories for breakfast, lunch, and dinner, respectively, and three snacks, each comprising 10% of calories, presented 2.5 h after the meal. In study C (large dinner), 10% of calories were consumed at breakfast, 20% at lunch, and 70% at dinner. Glucose, insulin, and Cpeptide concentrations were measured at 15- to 30-min intervals. Insulin secretion rates were calculated from C-peptide levels with individually derived C-peptide clearance parameters. The different eating patterns were associated with only modest differences in overall levels of glucose and insulin secretion. Daytime insulin secretion was lowest when most of the daily calorie intake occurred in the form of a large dinner. Overnight levels of glucose and insulin secretion rates did not differ for the three eating patterns, and the morning glucose levels were also unaffected by the pattern of calorie intake on the previous day. A morning rise of glucose of &amp;gt;0.28 mM occurred consistently only when dinner was of moderate size (30% of total calories). We conclude that if total calorie content and food composition are kept constant, overall blood glucose control is only modestly affected by the temporal pattern of food intake. The partition of food intake into meals and snacks does not improve glucose control, and a large dinner does not result in significantly higher overnight or next-morning glucose levels.
Endoscopic treatment combined with laparoscopic sentinel node mapping for superficial gastrointestinal cancers
Authors: Y. Kitagawa, M. Kitajima
Journal: Endoscopy (2007)

Endoscopic mucosal resection (EMR) has been established as a minimally invasive treatment for mucosal gastrointestinal cancer with no risk of lymph node metastasis. Recent advances in endoscopic technologies and devices, including the development of endoscopic submucosal dissection (ESD), have improved local control of superficial gastrointestinal cancer. Novel technologies in endoscopic treatments allow us to resect wider and deeper gastrointestinal cancer lesions. A current major limitation of EMR/ESD is the risk of micrometastasis in regional lymph nodes. To resolve this issue, attention has been focused on the concept of sentinel nodes. The first possible sites of metastasis along the lymphatic drainage route from the primary lesion are known as sentinel nodes. In the past 5 years, a number of single-center studies have been published that support the validity of the sentinel node concept for gastrointestinal cancers. The combination of EMR/ESD and laparoscopic/thoracoscopic sentinel node mapping seems to be a breakthrough that can extend the indication for the endoscopic treatment of gastrointestinal cancers with a potential risk of lymph node metastasis. Although there are several technical obstacles to overcome, this strategy has great potential in the near future as a novel minimally invasive treatment for superficial gastrointestinal cancers.
Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways
Authors: Porfirio Nava, Stefan Koch, Mike G. Laukoetter, Winston Y. Lee, Keli Kolegraff, Christopher T. Capaldo, Neal Beeman, Caroline Addis, Kirsten Gerner-Smidt, Irmgard Neumaier, Arne Skerra, Linheng Li, Charles A. Parkos, Asma Nusrat
Journal: Immunity (2010)
On the Post-Mortem Examination of the Ear, and the Frequency of Disease in or near the Tympanum
Authors: D. Foulis
Journal: BMJ (1880)

THE BRITISH MEDICAL JOURZVAL.6I9 that direction, and I believe that if I had not removed the scapula, I could not have covered the wound with healthy skin.I have not sought with any great minuteness to ascertain whether any similar case has been recorded in surgical works, i.e., where such.an operation has been performed, not for injury, but for disease.We are aware that in military practice immense damage has been inflicted upon the parts around the shoulder-joint.Large portions of bone and soft structures have been removed, and occasionally recovery has followed, and a useful limb has been preserved.But here, sad as it is to sacrifice the upper extremity, more particularly when, as in the present instance (as you will see for yourselves when the patient comes in), the use of the right limb is imperfect, the exigencies of the case will, I trust, justify in your opinion the very serious treatment to which I felt bound to subject this poor man.
Death Following the Intravenous Administration of Papaverine Hydrochloride
Authors: Elliot L. Sagall, Albert Dorfman
Journal: New England Journal of Medicine (1945)

THE intravenous administration of papaverine hydrochloride has been recommended in the treatment of peripheral embolism, pulmonary embolism, mesenteric embolism, impending gangrene due to ergot, Raynaud's disease, angina pectoris, acute myocardial infarction, cardiac arrhythmias, renal and biliary colic and bronchial asthma and for the measurement of the circulation time.1 2 3 4 5 6 7 8 9 10 11 12 Most discussions of its clinical employment stress its low toxicity and contain a paucity of warnings concerning possible dangers. Pal,1 who originally advocated its use, implied that the intravenous administration might be dangerous and used only small doses by that route. Elek and Katz11 concluded that intravenous injection may be contraindicated in . . .
Notes on the Anatomy and Surgery of Meckel's Diverticulum
Authors: G. A. Clarkson
Journal: BMJ (1901)

or an insignificant pouch.If the process of its involution is carried still further, it is supposed that an annular constric- 'tion or an actual occlusion of the bowel may take place.And .there are some cases in which a fibrous cord or a polypus re-
G-Protein β <sub>3</sub> -Subunit 825T Allele Is Associated With Enhanced Human Atrial Inward Rectifier Potassium Currents
Authors: D. Dobrev, E. Wettwer, H. M. Himmel, A. Kortner, E. Kuhlisch, S. Schüler, W. Siffert, U. Ravens
Journal: Circulation (2000)

A C825T polymorphism was recently identified in the human gene encoding for the beta(3)-subunit of heterotrimeric G proteins. The 825T allele is associated with a splice variant of Gbeta(3) and enhanced signal transduction. We hypothesized that patients carrying the 825T allele exhibit the modified Gbeta(3) phenotype. The resulting enhancement of signal transduction should be detectable in the Gbetagamma-dimer-mediated acetylcholine-stimulated K(+) current (I(K,ACh)).Seventy patients undergoing cardiac surgery were genotyped for the C825T polymorphism. In right atrial myocytes from these patients, the inward rectifier K(+) currents (I(K1), I(K,ACh)) were studied with the whole-cell patch-clamp technique. Background current I(K1) was measured with depolarizing ramp pulses and quantified as inward current at -100 mV; mean amplitudes were (pA/pF) 4.98+/-0.49 (n=30/93 patients/cells) in patients with CC genotype, 4.25+/-0.36 (n=31/121 patients/cells) with TC, and 7. 46+/-1.14 (n=9/32 patients/cells; P<0.05) with TT. Conversely, mean I(K,ACh), which is maximally activated by carbachol (2 micromol/L), was reduced in patients with TT genotype (pA/pF, 4.30+/-1.33, n=9/27 patients/cells; P<0.05) compared with the other 2 groups (6.56+/-0. 54, n=30/80 and 6.16+/-0.45, n=31/117 patients/cells, for CC and TC genotype, respectively). Essentially similar results were obtained with adenosine (1 mmol/L).We found an association between the Gbeta(3) 825T allele and amplitude of human atrial I(K1) and I(K,ACh). Increased background current density in TT carriers could shorten action potential duration and may be due to I(K,ACh) being constitutively active in this genotype.
Angiotensinogen genotype is associated with myocardial cell hypertrophy in patients with idiopathic dilated cardiomyopathy
Authors: Hiroya Sakuramoto, Yoshiyuki Yokota, Motoshi Takeuchi, Hiroya Kawal, Tatsuro Ishida, Tsuyoshi Sakoda, Seinosuke Kawashima, Hozuka Akita, Mitsuhiro Yokoyama
Journal: Journal of the American College of Cardiology (1996)
“Latex‐fruit syndrome”: frequency of cross‐reacting IgE antibodies
Authors: R. Brehler, U. Theissen, C. Mohr, T. Luger
Journal: Allergy (1997)

An association between allergies to latex proteins and to various foods has been reported and confirmed by RAST and immunoblotting inhibition. However, no significant data had been collected on the frequency of specific IgE antibodies to fruits in these patients and the frequency of a history of fruit intolerance. Serum samples of 136 patients with well‐documented, clinically relevant, immediate‐type hypersensitivity against latex proteins were analyzed for IgE antibodies against a panel of different fruits. Patient history of food intolerance was documented by a standardized questionnaire. Fruit‐specific IgE antibodies were detected in 69.1% of serum samples. Cross‐reacting IgE antibodies recognizing latex and fruit allergens (papaya, avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, and tomato) were demonstrated by RAST‐inhibition tests. Of our patients, 42.6% reported allergic symptoms after ingestion of these fruits and a total of 112 intolerance reactions were recorded. However, fruit‐specific IgE antibodies were detected only in serum samples from 32.1% of the patients who perceived symptoms due to these fruits. Thus, serologic tests seem to be of low significance for prediction of food allergy in latex‐allergic patients.
Development of tripartite polyion micelles for efficient peptide delivery into dendritic cells without altering their plasticity
Authors: Ariane Boudier, Anne Aubert-Pouëssel, Naila Mebarek, Alain Chavanieu, Julie Quentin, Delphine Martire, Hassan Boukhaddaoui, Corine Gérardin, Christian Jorgensen, Jean-Marie Devoisselle, Pascale Louis-Plence, Sylvie Bégu
Journal: Journal of Controlled Release (2011)
Myelopathy After Duck Embryo Vaccine
Authors: Harold N. Mozar
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The clinical picture did indeed suggest the Guillain-Barré syndrome, and this diagnosis would probably have been more appropriate. However, involvement of the anterior horn cells exclusively was not ruled out, and there is little certainity of the origin of the Guillain-Barré syndrome as a distinct nosologic entity. We had been unable to find published reports describing Guillain-Barré neuropathy as a reaction to duck embryo rabies vaccine. However, five cases of cranial or peripheral neuropathy are included in the rabies surveillance summary issued in January 1973 by the PHS Center for Disease Control. This summary covers reactions reported in the 15 years (1957-1971) since duck embryo rabies vaccine was first licensed and made available commercially. An estimated 424,000 persons were given nearly 6,000,000 doses of the vaccine during this period. The 15-year summary also mentions 37 cases of minor and transient neurologic symptoms, 4 cases of transverse myelitis,
Downregulation of interferon alpha but not gamma receptor expression in vivo in the acquired immunodeficiency syndrome.
Authors: A S Lau, S E Read, B R Williams
Journal: Journal of Clinical Investigation (1988)

Interferons (IFN) elicit antiviral and antineoplastic activities by binding to specific receptors on the cell surface. In evaluating the role of IFN as therapeutic agents in AIDS, we investigated the expression of IFN alpha and gamma receptors on peripheral blood mononuclear cells (PBM) from patients with AIDS, ARC, and heterosexual control subjects using radioiodinated IFN alpha 2 and IFN gamma. The binding characteristics of the 125I-IFN alpha and gamma to PBM were analyzed to determine receptor numbers and dissociation constants. PBM from controls expressed 498 +/- 247 IFN alpha receptor sites/cell (n = 17). However, eight patients with ARC and seven patients with AIDS had a mean number of IFN alpha receptor/cell of 286 +/- 235 (P less than 0.05) and 92 +/- 88 (P less than 0.001), respectively. This was consistent with elevated levels of serum acid-labile IFN alpha and cellular 2-5A synthetase activity in patients. Treatment of PBM from the AIDS patients with exogenous IFN alpha in vitro resulted in minimal 2-5A synthetase induction in comparison to controls. In contrast, the expression of IFN gamma receptors in ARC (n = 5) and AIDS (n = 4) patients remained normal. Thus the decrease in IFN alpha receptor expression and consequent hyporesponsiveness to IFN alpha raises the question of the usefulness of IFN alpha therapy in end-stage AIDS. The normal expression of IFN gamma receptors in AIDS patients suggests that IFN gamma may prove useful in attempts to provide immune reconstitution.
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
Authors: Robert R Graham, Sergey V Kozyrev, Emily C Baechler, M V Prasad Linga Reddy, Robert M Plenge, Jason W Bauer, Ward A Ortmann, Thearith Koeuth, Ma Francisca González Escribano, the Argentine and Spanish Collaborative Groups, Bernardo Pons-Estel, Michelle Petri, Mark Daly, Peter K Gregersen, Javier Martín, David Altshuler, Timothy W Behrens, Marta E Alarcón-Riquelme
Journal: Nature Genetics (2006)
Tumour size and differentiation predict survival after liver resection for hepatocellular carcinoma arising from non-cirrhotic and non-fibrotic liver: A case-controlled study
Authors: V.S. Yip, D. Gomez, C.Y. Tan, S. Staettner, M. Terlizzo, S. Fenwick, H.Z. Malik, P. Ghaneh, G. Poston
Journal: International Journal of Surgery (2013)
Evidence for Expanding Physician Supply
Authors: Richard A. Cooper
Journal: Annals of Internal Medicine (2005)

Letters15 March 2005Evidence for Expanding Physician SupplyRichard A. Cooper, MDRichard A. Cooper, MDFrom Medical College of Wisconsin, Milwaukee, WI 53226.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-6-200503150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Fye and his colleagues at the ACC are to be congratulated for calling attention to the plight of cardiology or, more correctly, the plight of patients who will need cardiologists but who, because of shortages, will lack the opportunity to see them. It's a sad day when Americans cannot access the advanced cardiac care that our nation has invested so heavily in creating while billions are squandered on regulation, litigation, and other administrative intrusions. These not only add cost but, as Dr. Pedre notes, also create bureaucratic burdens that force physicians to leave practice altogether. It is ...References1. Council on Graduate Medical Education. Reassessing Physician Workforce Policy Guidelines for the U.S. 2000–2020. Washington, DC: U.S. Department of Health and Human Services; 2003. Google Scholar2. Garber AM, Sox HC. The U.S. physician workforce: serious questions raised, answers needed [Editorial]. Ann Intern Med. 2004;141:732-4. [PMID: 15520433] LinkGoogle Scholar3. Dranove D, Wehner P. Physician-induced demand for childbirths. J Health Econ. 1994;13:61-73. [PMID: 10134439] CrossrefMedlineGoogle Scholar4. Fisher ES, Wennberg DE, Stukel TA, Gottlieb DJ, Lucas FL, Pinder EL. The implications of regional variations in Medicare spending. Part 1: the content, quality, and accessibility of care. Ann Intern Med. 2003;138:273-87. [PMID: 12585825] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Richard A. Cooper, MDAffiliations: From Medical College of Wisconsin, Milwaukee, WI 53226. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoWeighing the Evidence for Expanding Physician Supply Richard A. Cooper The U.S. Physician Workforce: Serious Questions Raised, Answers Needed Alan M. Garber and Harold C. Sox Evidence for Expanding Physician Supply W. Bruce Fye Evidence for Expanding Physician Supply Vincent M. Pedre III Evidence for Expanding Physician Supply William A. Curry and Clyde Barganier Evidence for Expanding Physician Supply Sharon I.S. Rounds and Derek C. Angus Metrics Cited byHealth Care Policy, Quality Improvement, and Patient Safety in Pain Medicine Practice 15 March 2005Volume 142, Issue 6Page: 474KeywordsFallsGraduate medical educationHipStent implantationSurgeonsSurgery ePublished: 15 March 2005 Issue Published: 15 March 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Drug Interactions: The Death Pen-Reply
Authors: Paulo F. Costa
Journal: JAMA (1993)

<h3>In Reply.</h3> —Janssen Pharmaceutica regrets any confusion regarding the Hismanal (astemizole)-Nizoral (ketoconazole) pen. We took steps to curb the use of the pen in July 1992. The use of it that Drs Gelfand and Lancaster saw was inadvertent, and we are taking further action to see that the pens are no longer used. We are pleased to note that the Janssen representative did point out the potential for drug interactions to the physicians at the hospital display. This is in line with our standards for appropriately disseminating accurate information to health care providers. Nevertheless, we agree that, by itself, the pen could convey an inappropriate message. We regret the incident and thank Drs Gelfand and Lancaster for bringing it to our attention.
Effects of Sitosterol on the Cholesterol Concentration in Serum and Liver in Hypothyroidism
Authors: MAURICE M. BEST, CHARLES H. DUNCAN, Joan D. Wathen, Ursula Jegher
Journal: Circulation (1956)

The effects of the administration of the plant sterol, β-sitosterol, on the elevated serum lipids of hypothyroidism and on the cholesterol content of the liver have been investigated. In patients with hypothyroidism sitosterol administration, without dietary restriction, resulted in a reduction of serum cholesterol and other lipids. In the hypothyroid rat the addition of sitosterol to the diet prevented the increase in serum lipids and in the cholesterol content of the liver which otherwise occurs on a high-cholesterol diet.
REPORT OF A SUCCESSFUL CASE OF EXCISION OF THE CECUM, WITH END-TO-END ANASTOMOSIS.
Authors: FREDERICK HOLME WIGGIN
Journal: JAMA (1900)

of age who gave a history of having had recurring attacks of appendicitis covering a period of ten years.About six weeks previously the patient and her physician stated that she had had a more severe attack than on any of the other occasions, the abdominal pain being greater, and the constitutional symptoms more marked than formerly.Since that time the patient had been unable to take nourishment, even in a liquid form, without suffering pain in the right iliac region, accompanied by severe and persistent nausea.Consequently she had ac- customed herself to abstain from taking nourishment in any form for as long a period of time as possible.She was emaciated, was suffering from marked mental depression, her gums and tongue were much swollen and red, and there were various ecchymotic spots all over her
Controlled trial of cyclophosphamide in active chronic hepatitis.
Authors: I T Gilmore, R E Cowan, A T Axon, R P Thompson, M J Wheeler
Journal: BMJ (1979)

Cytomegalovirus infection associated with lower urinary-tract symptomsThree members of a renal unit had a similar complex of urinary tract symptoms.Cytomegalovirus (CMV) was recovered from the urine of all three.Antibody titres against CMV during or shortly after the acute phase were negative, subsequently rising in two.
Primary Mediastinal Germ Cell Tumor Evolving Into an Extramedullary Acute Megakaryoblastic Leukemia Causing Cord Compression
Authors: Govinda R. Brahmanday, Gabriela Gheorghe, Ishmael A. Jaiyesimi, Attilio Orazi, Richard Zekman, Rajul Parikh, Shannon M. Wills, Lawrence H. Einhorn
Journal: Journal of Clinical Oncology (2008)
On the Fabric of the Human Body
Authors: Zankhana Raval, Douglas W. Losordo
Journal: Circulation (2012)

De Humani Corporis Fabrica in 1543, Andreas Vesalius bestowed some of the greatest advancements of anatomic understanding since the time of Galen, correcting major misconceptions, eg, the notion that the great vessels originated in the liver.It took nearly 1500 years for this evolution in anatomic thinking to transpire.
Mouse Allergen Exposure is Associated With Increased Exhaled Nitric Oxide Levels and Decreased Lung Function Among Mouse Sensitized Children with Asthma
Authors: E.N. Torjusen, J.N. Saams, R. Peng, P. Breysse, G. Diette, E.C. Matsui
Journal: Journal of Allergy and Clinical Immunology (2010)
Prospective Correlation of Left Ventricular Performance with Murmurs and Sounds in Athletic Hearts.
Authors: Richard S. Crampton
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Prospective Correlation of Left Ventricular Performance with Murmurs and Sounds in Athletic Hearts.Richard S. Crampton, F.A.C.P., David M. Lavine, B.A.Richard S. Crampton, F.A.C.P.Search for more papers by this author, David M. Lavine, B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-819_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince athletic hearts may mimic diseased hearts with systolic murmurs and third sounds, 15 members of a 1970 national champion lacrosse team were evaluated before and during training. At peak fitness 11 had systolic murmurs at rest and 14 after exercise. Eleven of 15 had third sounds at rest. After exercise 10 of 15 had third sounds; 4 of the third sounds became louder, 2 appeared, and 3 disappeared. One athlete showed an early diastolic left ventricular inflow murmur at rest. These physical signs were related to simultaneous maximal rate of rise of left ventricular pressure (dp/dt), integrated isovolumetric pressure,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Richard S. Crampton, F.A.C.P.; David M. Lavine, B.A.Affiliations: Charlottesville, Va. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe heart of a dancer: Noninvasive cardiac evaluation of professional ballet dancersThe Noninvasive Cardiac Evaluation of Long-Distance Runners 1 May 1971Volume 74, Issue 5Page: 819-819KeywordsExerciseHeartSportsSystolic ejection murmur ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
Adrenal Weight-Maintaining Corticotropin in Carcinoma of Lung
Authors: John Nichols
Journal: JAMA (1963)

In two cases of carcinoma of the lung without Cushing's syndrome but with bilateral adrenal cortical hypertrophy, the tumor was found to be devoid of corticotropin with corticosteroid-releasing capacity. Both tumors, however, had an extractable "corticotropin-like material" with adrenal weight-maintaining capacity. These findings, suggesting two different kinds of corticotropin, may explain the bilateral cortical hypertrophy not infrequently found in patients with tumors but without Cushing's syndrome.