Estimating the Human Costs of Cancer Survivorship in Children
Authors: Patricia A. Ganz
Journal: Annals of Internal Medicine (2010)

Editorials6 April 2010Estimating the Human Costs of Cancer Survivorship in ChildrenPatricia A. Ganz, MD, Jacqueline N. Casillas, MD, MSHS, and Anne Coscarelli, PhDPatricia A. Ganz, MDFrom Jonsson Comprehensive Cancer Center and School of Public Health at University of California, Los Angeles, Los Angeles, CA 90095-6900; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095-1752; and Jonsson Comprehensive Cancer Center and Simms/Mann—University of California, Los Angeles Center for Integrative Oncology, Los Angeles, CA 90095-6931.Search for more papers by this author, Jacqueline N. Casillas, MD, MSHSFrom Jonsson Comprehensive Cancer Center and School of Public Health at University of California, Los Angeles, Los Angeles, CA 90095-6900; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095-1752; and Jonsson Comprehensive Cancer Center and Simms/Mann—University of California, Los Angeles Center for Integrative Oncology, Los Angeles, CA 90095-6931.Search for more papers by this author, and Anne Coscarelli, PhDFrom Jonsson Comprehensive Cancer Center and School of Public Health at University of California, Los Angeles, Los Angeles, CA 90095-6900; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095-1752; and Jonsson Comprehensive Cancer Center and Simms/Mann—University of California, Los Angeles Center for Integrative Oncology, Los Angeles, CA 90095-6931.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-7-201004060-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail One of the most spectacular results of the federal war on cancer has been the high rate of cure achieved for children with cancer, with complete remission rates as high as 90% that often portend long-term cure (1, 2). However, the human costs of cure are high, including acute toxicities and life-threatening treatments, financial stresses, and ongoing psychosocial effects for the patient and family. The latter two are especially manifest during the transition period from acute treatment to follow-up after therapy, which is associated with ongoing surveillance for recurrence and retreatment as necessary and assessment for potential late effects of ...References1. Linabery AM, Ross JA. Trends in childhood cancer incidence in the U.S. (1992-2004). Cancer. 2008;112:416-32. [PMID: 18074355] CrossrefMedlineGoogle Scholar2. Mariotto AB, Rowland JH, Yabroff KR, Scoppa S, Hachey M, Ries L, et al. Long-term survivors of childhood cancers in the United States. Cancer Epidemiol Biomarkers Prev. 2009;18:1033-40. [PMID: 19336557] CrossrefMedlineGoogle Scholar3. Oeffinger KC, Mertens AC, Hudson MM, Gurney JG, Casillas J, Chen H, et al. Health care of young adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Ann Fam Med. 2004;2:61-70. [PMID: 15053285] CrossrefMedlineGoogle Scholar4. Oeffinger KC, Mertens AC, Sklar CA, Kawashima T, Hudson MM, Meadows AT, et al; Childhood Cancer Survivor Study. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006;355:1572-82. [PMID: 17035650] CrossrefMedlineGoogle Scholar5. Mertens AC, Liu Q, Neglia JP, Wasilewski K, Leisenring W, Armstrong GT, et al. Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2008;100:1368-79. [PMID: 18812549] CrossrefMedlineGoogle Scholar6. Hudson MM, Mertens AC, Yasui Y, Hobbie W, Chen H, Gurney JG, et al; Childhood Cancer Survivor Study Investigators. Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. JAMA. 2003;290:1583-92. [PMID: 14506117] CrossrefMedlineGoogle Scholar7. Robison LL, Hudson MM, SklarCA, Ganz PA, eds. Pediatric cancer survivorship: the Childhood Cancer Survivor Study. J Clin Oncol. 2009;27:2207-415. Google Scholar8. Yeh JM, Nekhlyudov L, Goldie SJ, Mertens AC, Diller L. A model-based estimate of cumulative excess mortality in survivors of childhood cancer. Ann Intern Med. 2010;152:409-17. LinkGoogle Scholar9. Henderson TO, Amsterdam A, Bhatia S, Hudson MM, Meadows AT, Neglia JP, et al. Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer. Ann Intern Med. 2010;152:444-55. LinkGoogle Scholar10. Lehman CD, Isaacs C, Schnall MD, Pisano ED, Ascher SM, Weatherall PT, et al. Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening study. Radiology. 2007;244:381-8. [PMID: 17641362] CrossrefMedlineGoogle Scholar11. Recklitis CJ, Diller LR, Li X, Najita J, Robison LL, Zeltzer L. Suicide ideation in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2010;28:655-61. [PMID: 19841325] CrossrefMedlineGoogle Scholar12. Ganz PA, Casillas J, Hahn EE. Ensuring quality care for cancer survivors: implementing the survivorship care plan. Semin Oncol Nurs. 2008;24:208-17. [PMID: 18687267] CrossrefMedlineGoogle Scholar13. Cure Search. Children's Oncology Group. Children's Oncology Group Guidelines. Accessed at www.survivorshipguidelines.org on 29 January 2010. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Jonsson Comprehensive Cancer Center and School of Public Health at University of California, Los Angeles, Los Angeles, CA 90095-6900; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095-1752; and Jonsson Comprehensive Cancer Center and Simms/Mann—University of California, Los Angeles Center for Integrative Oncology, Los Angeles, CA 90095-6931.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-0265.Corresponding Author: Patricia A. Ganz, MD, Division of Cancer Prevention and Control, Research, Jonsson Comprehensive Cancer Center at University of California, Los Angeles, 650 Charles Young Drive South, Room A2-125, Center for the Health Sciences, Los Angeles, CA 90095-6900; e-mail, [email protected]ucla.edu.Current Author Addresses: Dr. Ganz: Division of Cancer Prevention and Control, Research, Jonsson Comprehensive Cancer Center at University of California, Los Angeles, 650 Charles Young Drive South, Room A2-125, Center for the Health Sciences, Los Angeles, CA 90095-6900.Dr. Casillas: Department of Pediatrics–Hematology/Oncology, University of California, Los Angeles, Box 951752, A2-410 Marion Davies Children's Center, Los Angeles, CA 90095-1752.Dr. Coscarelli: Jonsson Comprehensive Cancer Center and Simms/Mann Center for Integrative Oncology at University of California, Los Angeles, Box 956934, Suite 502, 200 Medical Plaza, Los Angeles, CA 90095-6934. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Model-Based Estimate of Cumulative Excess Mortality in Survivors of Childhood Cancer Jennifer M. Yeh , Larissa Nekhlyudov , Sue J. Goldie , Ann C. Mertens , and Lisa Diller Systematic Review: Surveillance for Breast Cancer in Women Treated With Chest Radiation for Childhood, Adolescent, or Young Adult Cancer Tara O. Henderson , Alison Amsterdam , Smita Bhatia , Melissa M. Hudson , Anna T. Meadows , Joseph P. Neglia , Lisa R. Diller , Louis S. Constine , Robert A. Smith , Martin C. Mahoney , Elizabeth A. Morris , Leslie L. Montgomery , Wendy Landier , Stephanie M. Smith , Leslie L. Robison , and Kevin C. Oeffinger Metrics Cited ByDisparities in Care for Cancer SurvivorsSystematic Review: Surveillance for Breast Cancer in Women Treated With Chest Radiation for Childhood, Adolescent, or Young Adult Cancer 6 April 2010Volume 152, Issue 7Page: 465-466KeywordsBreast cancerCancer preventionCancer treatmentChildrenHealth careHealth promotionLung and intrathoracic tumorsQuality of lifeThorax ePublished: 6 April 2010 Issue Published: 6 April 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...