tbuckley/cabot-search huggingface dataset:
Notes on Health Resorts: VI.--Montreux
Authors: S. Tidey
Journal: BMJ (1892)

THE International Commission for studying the drainage of Cairo have, we learn from telegraphic despatches to the Time8, examined thirty projects presented to them, and re- jected all in favour of one elaborated by themselves.They especially commend, however, three projects as embodying in their general outlines the right system.These were presented by Messrs. Michau and Donaue, a French firm; Mahmoud Fehmy, an Egyptian; and Mr. John Price, an Englishman, the two latter engineers in the Government service.The Commission consider that Mr. Lathom's scheme, presented two years ago, has the disadvantages of costliness, and of re- quiring numerous stations in the heart of the city where the sewage would collect and undergo agitation.
Medical rules are needed in marathons in the United Kingdom
Authors: P. Loyley, P. Loyley
Journal: BMJ (1999)

EDITOR—Dyer reports that two junior doctors, Andrew Murphy and Lesley McKee, went to the aid of a marathon runner who collapsed and died as she crossed the finishing line of a half marathon.1 Dyer reports Dr Murphy as saying that if he was faced with a similar emergency in future he would “just walk on by.” We understand his comments.

It should not have been necessary for a doctor who had just finished a gruelling half marathon to take part in a resuscitation attempt. Emergency medical assistance should remain the responsibility of race organisers and those hired to provide emergency …
Re: Abell et al.: Cost-effectiveness of femtosecond laser-assisted cataract surgery versus phacoemulsification cataract surgery (Ophthalmology 2014;121:10-6)
Authors: Cedric Schweitzer, Nathalie Hayes, Antoine Brezin, Beatrice Cochener, Philippe Denis, Pierre-Jean Pisella, Antoine Benard
Journal: Ophthalmology (2014)
Rituximab and Pemphigus — A Therapeutic Advance
Authors: Luis A. Diaz
Journal: New England Journal of Medicine (2007)

Pemphigus vulgaris and pemphigus foliaceus are rare autoimmune blistering diseases of obscure causes. The scientific bases for the therapy of these disorders have evolved in the past 60 years. Landmark studies demonstrated that intraepidermal blisters were subcorneal in pemphigus foliaceus1 and suprabasilar in pemphigus vulgaris2,3 and suggested that an ongoing process of epidermal-cell detachment (acantholysis) led to blister formation. Armed with this limited information, dermatologists in the 1950s began to use systemic steroids to treat these diseases. Before the use of corticosteroids, the diagnosis of pemphigus carried a poor prognosis; it was believed that if a patient survived for . . .
SKULL ROENTGENOGRAPHY IN HOSPITALIZED PSYCHIATRIC PATIENTS
Authors: ROBERT T. RUBIN, LYNNE E. RUBIN
Journal: American Journal of Psychiatry (1966)

Of 1,183 patients admitted to the U.C.L.A. Neuropsychiatric Institute during a three-year period, 212 adults and 98 children had skull X-rays performed. The incidence of positive findings which were relevant to the diagnosis and total management of the patient was three percent in both groups. Pneumoencephalograms were positive in three patients with organic brain disease in whom the skull X-rays were normal. There is a need for routine skull roentgenography surveys in university psychiatric hospital populations and for consideration of pneumoencephalography when organic pathology is suspect but the skull X-rays are negative.
Influence of simultaneous low amniotomy and oxytocin infusion and other maternal factors on neonatal jaundice: a prospective study.
Authors: W C Chew, I L Swann
Journal: BMJ (1977)

In a prospective study of 196 consecutive single births a significant increase in serum bilirubin concentrations was found in infants born after low amniotomy induction and oxytocin infusion compared with those born spontaneously. This relationship was not dose-dependent and may have been associated with artificial interruption of pregnancy rather than the oxytocin itself. Infants delivered after spontaneous labour accelerated by oxytocin showed no such increase. The hormonal surge at the spontaneous onset of labour may affect fetal enzyme induction, but other factors, such as methods of infant feeding and oral contraceptive use, were found not to be significant.
Double-blind placebo-controlled house dust mite control measures in adult patients with atopic dermatitis
Authors: C. Gutgesell, S. Heise, S. Seubert, A. Seubert, S. Domhof, E. Brunner, C. Neumann
Journal: British Journal of Dermatology (2001)

Background Avoidance of allergens has been shown to be of benefit in patients with atopic asthma sensitized to indoor allergens. In atopic dermatitis, there is so far little information about the effect of house dust mite elimination strategies. Objectives We therefore performed a randomized controlled study of house dust mite control in patients with this disease. Methods Twenty adult patients with moderate to severe atopic dermatitis were included. Inclusion criteria were a positive RAST to house dust mite antigen (CAP class > 3) and a concentration of > 2 µg g−1 of the house dust mite antigen Der p1 in the patient's mattress dust. Patients were randomized to either the active treatment group (allergen‐impermeable mattress encasing, acaricide spray containing tannic acid and benzylbenzoate) or a control group (allergen‐permeable encasing, spray containing water and traces of ethanol). Severity of disease was estimated every 2 months by an established score (SCORAD), and eosinophil cationic protein (ECP) in the serum was determined by enzyme‐linked immunosorbent assay. Furthermore, the use of topical steroids was quantified. Patients assessed daytime pruritus and pruritus‐induced sleeplessness weekly on a visual analogue scale. The study lasted 1 year. Results At the end of the study, the active treatment group showed a statistically significant reduction in Der p1 exposure as compared with the control group. However, when comparing the change from the start to the end of the study, there was no statistically significant difference between active treatment and control groups as measured by the SCORAD score and by ECP levels in the serum. Some patients in the active treatment group reported less pruritus‐induced sleeplessness, but there was no statistically significant difference between the two treatment groups. Conclusions For adult patients with atopic dermatitis it was shown that 1 year of house dust mite avoidance reduced the allergen exposure, but an improvement of overall disease activity was not demonstrated.
Expression of the 27-kDa heat shock protein in human epidermis and in epidermal neoplasms: an immunohistological study
Authors: F. TRAUTINGER, I. KINDAS-MUGGE, B. DEKROUT, R.M. KNOBLER, D. METZE
Journal: British Journal of Dermatology (1995)

The 27-kDa heat shock protein (HSP27) is a member of the small heat shock protein (HSP) family. In addition to its putative function in thermotolerance, this protein may play a part in the regulation of cell growth and differentiation. This study was conducted to assess the significance of the expression of HSP27 in human epidermis and in cutaneous neoplasms. Sixty-two biopsy samples from normal human skin and from inflammatory and neoplastic skin diseases were investigated by immuno-histochemistry on formalin-fixed paraffin-embedded tissue sections, using a monoclonal antibody specific for HSP27. In normal human epidermis, HSP2 7 is expressed in the upper epidermal layers with a cytoplasmic staining pattern. The basal cell layer does not express detectable amounts of HSP27. In hair follicles, staining is mainly confined to the outer root sheath and to the infundibular epithelium. Melanocytes, dermal fibroblasts and endothelial cells do not express detectable amounts of HSP27. HSP27 could not be detected in fetal skin until the 20th week of gestation. Tumour cells in basal and squamous cell carcinomas do not express significant amounts of HSP27. In solar keratoses, seborrhoeic keratoses, human papillomavirus (HPV)-induced hyperproliferative lesions and inflammatory skin conditions, HSP27 expression largely resembles the pattern observed in normal human skin. HSP27 is expressed in a differentiation-related pattern in normal human epidermis and hyperproliferative disorders of the epidermis. We conclude that HSP27 may be regarded as a marker of differentiation in epidermal keratinocytes. Absence of HSP27 in the upper epidermal layers may be a marker for epidermal malignancy.
THE BLOOD IN PNEUMONIA.
Authors: ALFRED STENGEL
Journal: JAMA (1899)

In discussing this aspect of the question before the Section I shall address myself only to the clinical examinations of the blood possible to the general practitioner. The bacteriologist has been able to isolate the pneumococcus from the blood of pneumonic cases, especially such as are complicated by secondary infectious foci; but this can only be accomplished by skilled investigators and in clinical laboratories. Similarly, the determination of the amount of fibrin in the blood is a matter that must be left to proficient chemists. The French have taught that the quantity of fibrin may be determined by a study of the reticulum formed under a coverglass. This teaching is certainly very far from accurate. Even if the method were reliable, the quantity of fibrin in the blood is of little practical importance. The recent studies of Pfeiffer and others have shown that there is a notably increased amount of fibrin in the blood in leucocytosis, but
Disaster Response: Principles of Preparation and Coordination
Authors: Nancy L. Caroline
Journal: JAMA (1992)

The word "disaster" conjures up different images to different people. To the fire fighter, it may mean a high-rise office building in flames; to an air traffic controller, it is wrecked aircraft; to an international relief worker, it may be an earthquake or flood or famine or civil strife. So it is useful to start by stating what<i>Disaster Response</i>is not about. It is not a book about dealing with famine in Africa, flooding in Bangladesh, or even an earthquake in Armenia. As the author is careful to point out, this book addresses the specific problems of responding to multicasualty incidents in the United States or countries having similar infrastructure and a similarly organized system of emergency medical services. It is, furthermore, primarily a book for those with managerial, rather than medical, responsibility for the planning and implementation of a disaster response. Reviewing a host of incidents reported in
Robin Gordon Mitchell
Authors: A. Gray, D. Caesar, T. Parke
Journal: BMJ (2011)

Robin Gordon Mitchell, MB ChB, MRCP, FFAEM, FACEM, emergency medicine specialist and director of training at Auckland City Hospital, died peacefully in Mercy Hospice, Auckland, New Zealand, on 7 July 2010 from pancreatic cancer. He leaves a wife, Jo, and a daughter, Abigail.

Robin was born in Lanark, Scotland, on 9 September 1964. He was educated at Hardy School in Dorchester and represented the school in many sports, including cricket and swimming. He returned to Scotland as an undergraduate at Edinburgh University, where he excelled academically. He was also selected for the Scotland U21 rugby squad.

Robin completed his MRCP before training in emergency medicine in Edinburgh. He was appointed to his first consultant post in Christchurch Hospital, gaining his FACEM …
Fas ligand is localized to membrane rafts, where it displays increased cell death–inducing activity
Authors: Nathalie Cahuzac, Wiebke Baum, Vladimir Kirkin, Fabien Conchonaud, Laure Wawrezinieck, Didier Marguet, Ottmar Janssen, Martin Zörnig, Anne-Odile Hueber
Journal: Blood (2005)
The Wrong Type of PR
Authors: Mike Mitka
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Clinical Model to Estimate the Pretest Probability of Lung Cancer, Based on 1198 Pedigrees in China
Authors: Huan Lin, Wen-Zhao Zhong, Xue-Ning Yang, Xu-Chao Zhang, Jin-Ji Yang, Qing Zhou, Hong-Hong Yan, Ri-Qiang Liao, Qiang Nie, Song Dong, Yi-Long Wu
Journal: Journal of Thoracic Oncology (2012)
Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis
Authors: A Nishio, J Van de Water, P S Leung, R Joplin, J M Neuberger, J Lake, A Bjorkland, T H Totterman, M Peters, H J Worman, A A Ansari, R L Coppel, M E Gershwin
Journal: Hepatology (1997)

Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by destruction of intrahepatic bile ducts. Although the pathogenesis of this disease is still unknown, high titers of antimitochondrial autoantibodies (AMA) have long been recognized in patient sera. However, little is known about the presence of AMA in bile. In this study, we investigated bile and sera from patients with PBC and healthy controls for the presence of AMA and mitochondrial autoantigens. AMA were detected in the bile of 17 of 19 patients (89.4%) with PBC; they were specifically directed against the pyruvate dehydrogenase complex (PDC-E2) in 15 of 19 patients (78.9%), to the branched-chain 2-oxo-acid dehydrogenase complex E2 (BCOADC-E2) in 6 of 19 patients (31.6%), and to the 2-oxoglutarate dehydrogenase complex E2 (OGDC-E2) in 1 of 19 patients (5.3%). In a comparative study of sera from the same patients, anti-PDC-E2 antibodies were found in 19 of 19 patients (100%), anti-BCOADC in 9 of 19 patients (47.3%), and anti-OGDC-E2 in 4 of 19 patients (21.1%) patients. AMA in bile were always found together with antibodies of corresponding specificities in the serum from the same patient. Immunoglobulin (Ig)A AMA were found in the bile of 9 of 19 patients (47.7%) with PBC; they were specifically directed against PDC-E2 in 8 of 19 patients (42.1%) and to BCOADC in 2 of 19 patients (10.5%). Epitope mapping of IgA anti-PDC-E2 antibodies indicated that, like serum autoantibodies, the immunodominant epitope is directed against the inner lipoyl domain of PDC-E2. The prevalence and antigen reactivity of IgA AMA in sera correlated completely with IgA AMA in bile. Autoantibodies against nuclear envelope pore proteins (gp210) were found in 1 of 8 (12.5%) sera of patients with PBC, but not in bile. Furthermore, and of particular interest, we detected the autoantigens, PDC-E2, OGDC-E2, and BCOADC-E2, in the bile of 12 of 19 patients (63.2%), 9 of 19 patients (47.4%), and 9 of 19 patients (47.4%), respectively; PDC-E2 was found in only 1 of 17 (5.9%) disease controls. Although the presence of AMA in bile may merely reflect the presence of these antibodies in sera, the simultaneous detection of mitochondrial autoantigens in bile suggests an increase of mitochondrial autoantigens at inflammatory sites. Such autoantigens, coupled with AMA, may augment the local immune response and disease progression.
Symptom coaching: Factitious disorder by proxy with older children
Authors: Mary J. Sanders
Journal: Clinical Psychology Review (1995)

This paper proposes the idea that the story of factitious or exaggerated illness is coauthored or that symptoms may be coached through the dynamics of the family. The physician is unwittingly engaged as a coauthor by performing diagnostic tests and treatments. Children and family members may be invited to coauthor or collude in the presentation of false symptoms as well. The importance of assessing the participation of family members in illness presentation was discussed as well as the difficulty in determining intentionality of symptom production. Four cases are presented including test data which indicate that the more “active” the family may be in presentation of symptoms, the more likely they are to present a cohesive family picture and to seek outside support and the less likely they are to report Stressors. Treatment ideas include acknowledging the possibility of both conscious and unconscious production of symptoms by family members in the creation of a story of illness. Treatment suggestions included the promotion of an alternative story to illness.
Atypical Antipsychotic Drug Use and Diabetes
Authors: Jambur Ananth, Ravi Venkatesh, Karl Burgoyne, Sarath Gunatilake
Journal: Psychotherapy and Psychosomatics (2002)

Recently, there has been increased concern about the occurrence of diabetes associated with the use of atypical antipsychotic (AAP) drugs. The relationship between diabetes, schizophrenia, and antipsychotic drugs is complex and intriguing, as untreated patients with schizophrenia are known to suffer from diabetes more often than the general population. Thirty individual case reports of clozapine-, 26 cases of olanzapine- and a few others of seroquel- and risperidone-associated diabetes mellitus, hyperglycemia and diabetic ketoacidosis were found by a Medline search. The case reports do not provide the incidence of diabetes in patients treated with AAP drugs, but they suggest that AAP drugs may cause hyperglycemia. Further research is needed to identify the cause of the susceptibility of the schizophrenic population, and to elucidate the mechanisms by which the antipsychotic drugs either cause diabetes or precipitate its onset. Which antipsychotic drugs have a higher and which have a lower potential to induce diabetes is not conclusively answered at present. However, the findings that 50% of the patients completely improve upon drug discontinuation, and that hyperglycemia promptly recurs upon reinstitution of the incriminated drug indicate that this side effect is reversible and is drug related. African Americans are particularly susceptible to AAP drug-induced diabetes. Until the new research data become available, AAP drug treatment of schizophrenic patients aims at prevention, institution of vigilant screening procedures, and management of hyperglycemia.
Chorea in Relation to Scarlet Fever
Authors: J. Priestley
Journal: BMJ (1897)

CASE Ix.Eczema.-Hospitalpatient: While under treatment for tinea barb., developed a papular and erythematous eczema of flexor surface of both upper arms.Worse on the right.and involving bend of elbow.CASE X. Eczema.-Hospitalpatient: While under treatment for a bulla of right forefinger, the cause of which it was impossible to ascertain, developed an attack of eczema of the left arm and left side of face.CASE XI.Vesicutlar Eruption -Private patient: A lady showed me a small "blister" on the right ring-finger, for which a mild boracic oint- ment was ordered.In a few days she developed a large vesicular erup- tion on both hands, attended with malaise, headIache, and gastro-intestinal catarrh.CASE XTI.Erythema Mfultijorme.-Hospitalpatient: A girl, aged I2, six or seven weeks before coming under observation, had pediculi capitis and "sores" on the, scalp.On January 4th "blisters" first formed round the mouth and nostrils, became purulent and confluent, and now presented the appearance of an ordinary impetiginous eruption.On January ixith a multiform erythenma, very extensive and well marked.appeared on both arms; at the same time a bullous erythema appeared on the face and front of neck. REMARKS.These twelve cases may be divided into two classes: First, those in which the eruption followed the infliction of an injury; and, secondly, those in which a pre-existing inflammatory condition of the skin, presumably of a non-traumatic origin, being in evidence.A condition common to both was the formation of pus and sepsis.It is interesting to observe the different types of the eruptions and the preponderating number of cases classed as eczematous, six being of this class, three pemphigus orpemphigoid, two erythematous, and one impetiginous.What are these different pathological conditions due to? Are they caused by one poison or many generated in the process of sepsis?Is it possible that the same poison will induce one type of eruption in one individual and a different one in another.I venture to think that one toxin is capable of causing them all, the difference in type being due to the susceptibility of the tissues of the patients attacked with this modified form of septic&emia.The eruptions were all acute or subacute, and as far as can be ascertained were attended with more or less systemic disturbance.Do not the foregoing cases suggest to us that many skin affections which have been attributed to vasomotor disturb- ance and reflex irritation are due to the absorption of micro- organisms or their products either by the skin or alimentary tract?It behoves us, therefore, to pay more attention to wounds of the integument, however trifling, in endeavouring to explain the cause of certain skin diseases.
Flow in the aorta and patent ductus arteriosus in infants with aortic atresia or aortic stenosis: a pulsed Doppler ultrasound study.
Authors: J L Bass, J M Berry, S Einzig
Journal: Circulation (1986)

We used pulsed Doppler ultrasound to determine the flow dynamics of the aorta and patent ductus arteriosus (PDA) in 21 infants (ages 1 to 16 days) with PDA and aortic atresia (n = 15) or aortic stenosis (n = 6). The flow within the PDA was recorded in 19, and was right-to-left during systole in all. There was a diastolic left-to-right PDA shunt in 11 patients with aortic atresia and in three with aortic stenosis, and the shunt was associated with large (3 to 11 mm in diameter) interatrial communications. In two patients with aortic atresia and three with aortic stenosis, however, the diastolic PDA shunt was from right to left, and the interatrial communications were small (0 to 2 mm in diameter). The right-to-left diastolic PDA shunting may be best explained by the relative pulmonary (high with left-sided inflow obstruction and a small interatrial communication) and systemic resistances. All patients with aortic atresia and three with aortic stenosis had retrograde systolic flow in the transverse aortic arch, probably resulting from inadequate left ventricular output. Antegrade diastolic flow in the transverse aortic arch toward the PDA was observed in all infants with aortic atresia and a left-to-right PDA shunt. Ascending aortic flow was recorded in 11 patients with aortic atresia, and was retrograde during diastole in each, the result of coronary perfusion. Application of pulsed Doppler ultrasound can lead to a better understanding of the hemodynamics and physiology of patients with congenital cardiovascular disease.
P150 INTERFERON-STIMULATED GENE 15, A PROVIRAL FACTOR FOR HEPATITIS C VIRUS, AND PROTEASOME SUBUNIT ALPHA TYPE-6 ARE INDUCED BY POLY(I:C) AND RECIPROCALLY AFFECT EACH OTHER
Authors: R. Broering, M. Trippler, M. Lutterbeck, C.I. Real, K. Kleinehr, L. Poggenpohl, G. Gerken, J.F. Schlaak
Journal: Journal of Hepatology (2014)