tbuckley/cabot-search huggingface dataset:
Rapid and sustained coronary artery recanalization with combined bolus injection of recombinant tissue-type plasminogen activator and monoclonal antiplatelet GPIIb/IIIa antibody in a canine preparation.
Authors: H K Gold, B S Coller, T Yasuda, T Saito, J T Fallon, J L Guerrero, R C Leinbach, A A Ziskind, D Collen
Journal: Circulation (1988)

The effects of bolus injections of recombinant single-chain tissue-type plasminogen activator (rt-PA) and of F(ab')2 fragments of a murine monoclonal antibody (7E3) against the human platelet GPIIb/IIIa receptor [7E3-F(ab')2] on coronary arterial thrombolysis and reocclusion was studied in a canine preparation of coronary artery thrombosis superimposed on high-grade stenosis. Bolus intravenous injections of rt-PA at a dose of 0.45 mg/kg, repeated at 15 min intervals until reperfusion occurred (maximum of four injections) caused reperfusion in five of seven dogs within 100 min (33 +/- 15 min, mean +/- SD). Reperfusion was rapidly followed (generally within 10 min) by reocclusion and then by periods of cyclical reflow and reocclusion. A single intravenous injection of 7E3-F(ab')2 alone at 0.8 mg/kg caused reperfusion within 100 min in two of six dogs (19 and 37 min) without subsequent reocclusion. Single bolus injections of different amounts (0.1 to 0.8 mg/kg) of 7E3-F(ab')2 were then combined with bolus injections of 0.45 mg/kg of rt-PA. Stable reperfusion without reocclusion was accomplished with 0.8 or 0.6 mg/kg 7E3-F(ab')2 and a single injection of 0.45 mg/kg rt-PA within 6 +/- 3 min (n = 6, p less than .01) and 8 +/- 5 min (n = 5, p less than .02), respectively. None of these animals suffered reocclusion of the coronary artery. Lower doses (0.1 to 0.2 mg/kg) of 7E3-F(ab')2 did not significantly shorten the time to reperfusion and did not prevent reocclusion.(ABSTRACT TRUNCATED AT 250 WORDS)
Randomised controlled trial of graded exercise in patients with the chronic fatigue syndrome
Authors: K. Y Fulcher, P. D White
Journal: BMJ (1997)

To test the efficacy of a graded aerobic exercise programme in the chronic fatigue syndrome.Randomised controlled trial with control treatment crossover after the first follow up examination.Chronic fatigue clinic in a general hospital department of psychiatry.66 patients with the chronic fatigue syndrome who had neither a psychiatric disorder nor appreciable sleep disturbance.Random allocation to 12 weeks of either graded aerobic exercise or flexibility exercises and relaxation therapy. Patients who completed the flexibility programme were invited to cross over to the exercise programme afterwards.The self rated clinical global impression change score, "very much better" or "much better" being considered as clinically important.Four patients receiving exercise and three receiving flexibility treatment dropped out before completion. 15 of 29 patients rated themselves as better after completing exercise treatment compared with eight of 30 patients who completed flexibility treatment. Analysis by intention to treat gave similar results (17/33 v 9/33 patients better). Fatigue, functional capacity, and fitness were significantly better after exercise than after flexibility treatment. 12 of 22 patients who crossed over to exercise after flexibility treatment rated themselves as better after completing exercise treatment 32 of 47 patients rated themselves as better three months after completing supervised exercise treatment 35 of 47 patients rated themselves as better one year after completing supervised exercise treatment.These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with the chronic fatigue syndrome.
Surgery and the pill.
Authors: J Guillebaud
Journal: BMJ (1985)

This article on oral contraceptive (OC) use in relation to surgery recommends that estrogen-containing contraceptives should be discontinued 4 weeks before major elective surgery and started again at the 1st menses occurring at least 2 weeks after the procedure.  After major surgery the relative risk of deep venous thrombosis is about 2 in users of estrogen-containing OCs compared with nonusers.  The risk is greatest after major orthopedic abdominal and cancer surgery or any surgery that entails a hypotensive anesthetic.  The excess risk of deep venous thrombosis appears to be unrelated to duration of OC use and reverts to normal within less than 1 month.  This policy implies that women must be given at least 1 months advance notice of their admission.  Special attention must be given to the risk of unwanted pregnancy when OC use is discontinued in anticipation of surgery.  The couple should be helped to organize alternate means of contraception during this interval.
Somatostatin Receptor Expression in Primary Gastric Versus Nongastric Extranodal B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type
Authors: M. Raderer, J. Valencak, F. Pfeffel, J. Drach, T. Pangerl, A. Kurtaran, M. Hejna, F. Vorbeck, A. Chott, I. Virgolini
Journal: JNCI Journal of the National Cancer Institute (1999)
Correction: Losartan, Pancreatitis, and Microlithiasis
Authors: Xavier Bosch
Journal: Annals of Internal Medicine (1998)

Letters1 November 1998Correction: Losartan, Pancreatitis, and MicrolithiasisXavier Bosch, MD, PhDXavier Bosch, MD, PhDHospital Casa Maternitat; 08028 Barcelona, SpainSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-9-199811010-00041 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the 1 December 1997 issue [1], I described a 39-year-old man who developed acute pancreatitis while receiving losartan, 50 mg once daily, for hypertension and again on rechallenge with 25 mg of losartan.On 5 December 1997, this patient was admitted with recurrent pancreatitis. Medications included atenolol, 50 mg once daily. Laboratory data revealed leukocytosis (leukocyte count, 18 × 109/L) with a normal differential, increased serum levels of pancreatic α-amylase (1146 IU/L [normal, 0 to 115 IU/L]) and lipase (1028 IU/L [normal, 0 to 190 IU/L]), and normal serum values of total bilirubin. Abdominal ultrasonography and ...References1. Bosch X. Losartan-induced acute pancreatitis [Letter]. Ann Intern Med. 1997; 127:1043-4. Google Scholar2. Gregor JC, Ponich TP, Detsky AS. Should ERCP be routine after an episode of “idiopathic” pancreatitis? A cost–utility analysis. Gastrointest Endosc. 1996; 44:118-23. Google Scholar3. Norton SA, Alderson D. Prospective comparison of endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the detection of bile duct stones. Br J Surg. 1997; 84:1366-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hospital Casa Maternitat; 08028 Barcelona, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAcute Pancreatitis Associated with Angiotensin II Receptor Antagonists 1 November 1998Volume 129, Issue 9Page: 755KeywordsBileEndoscopic retrograde cholangiopancreatographyHypertensionLaparoscopyLeukocytosisLipasesPancreatic ductsPancreatitisResearch laboratoriesUltrasound imaging Issue Published: 1 November 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Treatment of Melioidosis
Authors: Everett B. Copper
Journal: JAMA (1968)

<h3>To the Editor:—</h3> In an article entitled "Melioidosis," I discussed treatment of this disease (<b>200</b>:452, 1967). Because of the potential bone marrow, hepatic, renal, and eighth nerve toxicity of the high dosages of chloramphenicol, kanamycin sulfate, and sodium novobiocin sodium recommended as therapy for the severe unresponsive form of the disease, I wish to emphasize the indications and contraindications for this regimen. Melioidosis, like most infectious diseases, causes a spectrum of clinical manifestations ranging from inapparent disease to overwhelming infection, depending upon the virulence of the strain and host resistance. As with most gram-negative organisms, antibiotic susceptibility is quite variable. Therefore, therapy must be determined by two factors; the seriousness of the infection and the antibiotic sensitivity of the specific strain of<i>Pseudomonas pseudomallei</i>involved. It is of importance to realize that the majority of infections can be handled with tetracycline or chloramphenicol therapy in doses of 2 to
Pneumoperitoneum in Preparation for Correction of Giant Hernias
Authors: Matthew M. Mansuy, Henry G. Hager
Journal: New England Journal of Medicine (1958)

THE correction of giant hernias and eventrations has long offered a challenge to surgical skill and ingenuity. It has been aptly stated that many large hernias have lost the "right of domicile." Some of these cases, unfortunately, have been considered inoperable because of the feared complications of sudden change in intra-abdominal pressure and the technical difficulty encountered in the closure of the peritoneum and parietal layers after the return of the contents of the hernia sac to the abdominal cavity.We wish to report such a case that was successfully corrected surgically after the preliminary establishment of pneumoperitoneum. The degree . . .
Abstract P76: Assessment of Resuscitation Skills in Foundation Year 1 Hospital Doctors in Northern Ireland
Authors: Michael Connoly, Philip Toner, Nicole Sayee, David McCluskey, Mike Stevenson
Journal: Circulation (2008)

Aims: To assess Foundation Year 1 (F1) doctors’ ability to perform effective cardiopulmonary resuscitation (CPR) using different chest compression:ventilation ratios. Methods: All forty F1 doctors working in a major teaching hospital were asked to participate in the study. Thirty four doctors participated, eighteen male and sixteen female. BMI was recorded in each case. They were asked to perform two, three minute sessions of CPR on a skills reporter manikin separated by a five minute rest period. Half of the doctors started using a ratio of 15:2 and half used 30:2. After a five minute rest the alternate ratio was performed. Their performance was assessed both objectively, by measuring the rate and depth of chest compressions, and subjectively by a panel of five advanced life support (ALS) instructors who reviewed tracings of each CPR session. Results: Mean compression rate per minute was sixty five while performing 15:2 and ninety one at 30:2. Chest compressions were effective if &gt;38mm. Twenty three doctors (67.7%) achieved &gt;80% effective chest compressions at a ratio of 15:2, compared with nineteen doctors (55.9%) at 30:2. At 15:2, males were 89% effective compared to 44% of females. At 30:2 males were 83 % effective compared to 25% of females. At 15:2 82% of compressions were effective in BMI&gt;24 group compared with 50% of BMI&lt;24. At 30:2 BMI&gt;24 achieved 76% effective compared with 35% in BMI&lt;24 group. Outcome measures shown in table 1 show no statistical difference between 15:2 and 30:2. Subjectively, 41% of doctors were deemed effective at 15:2 compared with 35% at 30:2. Conclusions: A significant number of F1 doctors are unable to perform effective CPR. Objectively, F1 doctors performed better at 15:2 than 30:2 but no statistical significance was noted. Subjectively, ALS instructors favoured the 15:2 regieme. CPR was performed better by males and doctors with BMI&gt;24. F1 doctors’ should be carefully assessed before they act as first responders at in-hospital cardiac arrests. Mean difference between 15:2 and 30:2
Visualization of Non-Hodgkin??s Lymphoma by I-123 IMP
Authors: SHIGERU KOSUDA, SHUNJI KAWAHARA, KOHEI TAMURA, ATSUSHI KUBO, SHOZO HASHIMOTO
Journal: Clinical Nuclear Medicine (1988)

Imaging with I-123 IMP was performed in a patient with non-Hodgkln's lymphoma. The image showed visualization of all focal lesions, but with worse Imaging quality than Ga-67 imaging. This is the first report of I-123 IMP concentration in non-Hodgkin's lymphoma.
Risk Assessment for Continuous Flow Left Ventricular Assist Devices: Does the Destination Therapy Risk Score Work?
Authors: Jeffrey J. Teuteberg, Greg A. Ewald, Robert M. Adamson, Katherine Lietz, Leslie W. Miller, Antone J. Tatooles, Robert L. Kormos, Kartik S. Sundareswaran, David J. Farrar, Joseph G. Rogers
Journal: Journal of the American College of Cardiology (2012)
Mortal Diseases Among 1000 Ellis Fischel State Cancer Hospital Patients. With Comparison to the General Population
Authors: J. S. Spratt, M. G. Hoag
Journal: CA A Cancer Journal for Clinicians (1966)

eral and perticular Casualties? (10) What years are Fruitfull, and Mortal, and in what Spaces, and Intervals, they follow each other?(11) In what pro portion Men neglect the Orders of the Church, and Sects have increased?
Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damage
Authors: Abdurrahman Sagir, Andreas Erhardt, Marcus Schmitt, Dieter Häussinger
Journal: Hepatology (2007)

Transient elastography [FibroScan (FS)] is a rapid, noninvasive, and reproducible method for measuring liver stiffness, which correlates with the degree of liver fibrosis in patients with chronic hepatitis. Whether FS is useful in the detection of preexisting liver fibrosis/cirrhosis in patients presenting with acute liver damage is unclear. Patients with acute liver damage of different etiologies were analyzed. Liver stiffness was measured during the acute phase of the liver damage and followed up to the end of the acute phase. A total of 20 patients were included in the study. In 15 of the 20 patients, initial liver stiffness values measured by FS during the acute phase of the liver damage were suggestive of liver cirrhosis. However, none of these 15 patients showed any signs of liver cirrhosis in the physical examination, ultrasound examination, or liver histology [performed in 11 of 15 (73%) patients]. A significant difference was observed in the initial bilirubin levels (5.8 ± 6.5 mg/dL versus 15.7 ± 11.8 mg/dL; P = 0.042) and age (32.4 ± 17.5 years versus 49.7 ± 15.8 years; P = 0.042) between patients with liver stiffness below or above 12.5 kPa. Six patients with initially high liver stiffness were followed up to abatement of the acute hepatitic phase; in all of them, liver stiffness values decreased to values below the cutoff value for liver cirrhosis. Conclusion: Transient elastography frequently yields pathologically high values in patients with acute liver damage and is unsuitable for detecting cirrhosis/fibrosis in these patients. (Hepatology 2007.)
Autocrine cell suicide in a Burkitt lymphoma cell line (Daudi) induced by interferon α: involvement of tumor necrosis factor as ligand for the CD95 receptor
Authors: Heinz Gisslinger, Razelle Kurzrock, Bettina Gisslinger, Shuwei Jiang, Shuren Li, Irene Virgolini, Wolfgang Woloszczuk, Michael Andreeff, Moshe Talpaz
Journal: Blood (2001)
The Efficacy of Antiarrhythmic Agents During Acute Myocardial Ischemia and the Role of Heart Rate
Authors: RONALD R. HOPE, DAVID O. WILLIAMS, NABIL EL-SHERIF, RALPH LAZZARA, BENJAMIN J. SCHERLAG
Journal: Circulation (1974)

The influence of lidocaine, procaine amide, and propranolol on ventricular arrhythmias during acute myocardial ischemia in the dog was examined. Ischemic zone epicardial (IZE) activation delay and the time of onset of ventricular tachycardia (VT t ) were studied. Progressive IZE delay always preceded ventricular tachycardia (VT). Ventricular tachycardia occurred when IZE delay extended into the T wave of the standard electrocardiogram but areas of ischemic epicardium were found in which activation delayed beyond the T wave. Fast heart rates during acute ischemia were associated with an accelerated time course of IZE delay and early VT. Slow heart rates resulted in minimal IZE delay and delayed onset or absence of VT. Sympathectomized dogs with heart rates 32% slower than normal dogs did not develop significant IZE delay or VT during ischemia. When heart rates were increased by atrial pacing, these dogs behaved in the same fashion as the normal dogs with respect to IZE delay and VT t . Lidocaine was found to hasten the time course of IZE delay but to have no significant effect on VT t . Procaine amide did not influence IZE delay nor VT t during ischemia. Propranolol slowed the mean heart rate by 20% and appeared to protect against arrhythmia. When the heart rate (115 ± 10 beats/min; mean ± standard deviation) was increased by atrial pacing (184 ± 9 beats/min), propranolol did not significantly influence IZE delay or VT t as compared to the untreated controls. The clinical counterpart of our experiments during acute ischemia may relate to the prehospitalization phase of myocardial infarction.
Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response: a study of the GIMEMA CML WP
Authors: Nicoletta Testoni, Giulia Marzocchi, Simona Luatti, Marilina Amabile, Carmen Baldazzi, Monica Stacchini, Mauro Nanni, Giovanna Rege-Cambrin, Emilia Giugliano, Ursula Giussani, Elisabetta Abruzzese, Simonetta Kerim, Maria Grazia Grimoldi, Alessandro Gozzetti, Barbara Crescenzi, Carlo Carcassi, Paolo Bernasconi, Antonio Cuneo, Francesco Albano, Giuseppina Fugazza, Alfonso Zaccaria, Giovanni Martinelli, Fabrizio Pane, Gianantonio Rosti, Michele Baccarani
Journal: Blood (2009)
<b> <i>Lysyl Oxidase</i> </b> Is a Tumor Suppressor Gene Inactivated by Methylation and Loss of Heterozygosity in Human Gastric Cancers
Authors: Atsushi Kaneda, Kuniko Wakazono, Tetsuya Tsukamoto, Naoko Watanabe, Yukiko Yagi, Masae Tatematsu, Michio Kaminishi, Takashi Sugimura, Toshikazu Ushijima
Journal: Cancer Research (2004)

Abstract Lysyl oxidase (LOX) and HRAS-like suppressor (HRASLS) are silenced in human gastric cancers and are reported to have growth-suppressive activities in ras-transformed mouse/rat fibroblasts. Here, we analyzed whether or not LOX and HRASLS are tumor suppressor genes in human gastric cancers. Loss of heterozygosity and promoter methylation of LOX were detected in 33% (9 of 27) and 27% (26 of 96) of gastric cancers, respectively. Biallelic methylation and loss of heterozygosity with promoter methylation were also demonstrated in gastric cancers. Silencing of LOX was also observed in colon, lung, and ovarian cancer cell lines. As for mutations, only one possible somatic mutation was found by analysis of 96 gastric cancer samples and 58 gastric and other cancer cell lines. When LOX was introduced into a gastric cancer cell line, MKN28, in which LOX and HRASLS were silenced, it reduced the number of anchorage-dependent colonies to 57 to 61%, and the number of anchorage-independent colonies to 11 to 23%. Sizes of tumors formed in nude mice were reduced to 19 to 26%. Growth suppression in soft agar assay was also observed in another gastric cancer cell line, KATOIII. On the other hand, neither loss of heterozygosity nor a somatic mutation was detected in HRASLS, and its introduction into MKN28 did not suppress the growth in vitro or in vivo. These data showed that LOX is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in gastric cancers, and possibly also in other cancers.
MECHANISM OF EXOPHTHALMOS
Authors: W. Russell Brain
Journal: JAMA (1934)

<h3>To the Editor:—</h3> The editorial on "The Mechanism of Exophthalmos" inThe Journal, June 30, quotes what is termed "this curious statement" from my recent textbook "Diseases of the Nervous System": "Apart from gross neoplastic and inflammatory lesions of the orbit, the mechanism of expohthalmos is still little understood." Your comment is: "Nevertheless the mechanism of exophthalmos is well understood, though the knowledge would seem to be poorly disseminated." If the writer of your leader had done me the honor of quoting the article on exophthalmic goiter in my textbook, he would have found the explanation of exophthalmos which he proposes fully discussed and the conclusion drawn that "there is probably overaction of part of the ocular sympathetic fibers, causing retraction of the upper lids and some degree of exophthalmos." I am familiar with the various papers quoted in the leader and I agree that the muscles described by Landström
Role of Peroxynitrite in Airway Microvascular Hyperpermeability during Late Allergic Phase in Guinea Pigs
Authors: HISATOSHI SUGIURA, MASAKAZU ICHINOSE, TATSUYA OYAKE, YASUFUMI MASHITO, YUZURU OHUCHI, NAOMI ENDOH, MOTOHIKO MIURA, SHUNSUKE YAMAGATA, AKIRA KOARAI, TAKAAKI AKAIKE, HIROSHI MAEDA, KUNIO SHIRATO
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

We investigated the role of peroxynitrite, which is formed by a rapid reaction between nitric oxide (NO) and superoxide anion (O2 −), in the airway microvascular hyperpermeability during the late allergic response (LAR) in sensitized guinea pigs in vivo. The occurrence of LAR was assessed as a 100% increase in the transpulmonary pressure, which was monitored by the esophageal catheter technique. Airway microvascular permeability was assessed by Monastral blue dye trapping between the endothelium using an image analyzer. In the LAR phase (4 to 6 h after antigen inhalation), microvascular hyperpermeability and eosinophil infiltration within the airway wall were observed. NO production and xanthine oxidase (XO)/xanthine dehydrogenase activity, which are responsible for O2 − production, were enhanced during the LAR. Peroxynitrite formation assessed by nitrotyrosine immunostaining was also exaggerated at that time. The microvascular hyperpermeability during the LAR was largely reduced by NO synthase inhibitor (l-NAME, 72.7% inhibition; p < 0.05), XO inhibitor (AHPP, 60.8% inhibition; p < 0.05) and peroxynitrite scavenger (ebselen, 81.0% inhibition; p < 0.05). l-NAME had a small but significant inhibitory effect on airway eosinophil accumulation, but AHPP and ebselen had no effect. These results suggest that excessive production of O2 − and NO occurs in the LAR. These two molecules appear to cause airway microvascular hyperpermeability via peroxynitrite formation.
Plague prompts worldwide action
Authors: C Court
Journal: BMJ (1994)

Health officials at airports around the world have responded to the outbreak of plague in India with measures ranging from screening passengers on arrival to banning all incoming flights from India (see editorial on p 893). At London's Heathrow airport last week port health inspectors were boarding all incoming flights to spray the atmosphere with an insecticide, pyrethrin, before passengers were allowed to disembark. Baggage was also being sprayed. All passengers were being issued with a pamphlet in various languages summarising the symptoms of plague and urging anyone feeling ill during the next three days to seek medical advice immediately.

Dr George Stewart, principle medical officer at Heathrow, said that airport staff …
Childhood monosomy 7 syndrome
Authors: Martin Gyger, Yvette Bonny, Lorraine Forest
Journal: American Journal of Hematology (1982)

Abstract In recent years, chromosomal aberrations in various hematologic disorders have raised a great deal of interest. In fact, several nonrandom chromosomal abnormalities are now recognized to be responsible for a specific type of dyshemopoiesis while others are closely associated with characteristic hematologic features. Monosomy C, later shown to be monosomy 7 by different banding methods, has been described in children in relation to a peculiar myeloproliferative disorder. Retrospective analysis of early cases published in the literature and a recent observation that we wish to report suggest that the most consistent phenotypic expression of monosomy 7 is an increased susceptibility to bacterial infections related to a preleukemic dyshemopoiesis. Acute nonlymphocytic leukemia is the terminal event of this peculiar preleukemic syndrome, and thus suggests that monosomy 7 involves a stem cell already committed to myeloid differentiation.