tbuckley/cabot-search huggingface dataset:
Vinyl chloride disorder
Authors: ANNE E. WALKER
Journal: British Journal of Dermatology (1981)

Journal Article Vinyl chloride disorder Get access ANNE E. WALKER ANNE E. WALKER Royal Hospital, Chesterfield, Derbyshire Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue s21, 1 September 1981, Pages 19–21, https://doi.org/10.1111/j.1365-2133.1981.tb01303.x Published: 01 September 1981
THE TEACHING OF LABORATORY PHYSIOLOGY
Authors: A. D. BUSH
Journal: JAMA (1913)

At a time when there is growing complaint about the overcrowding of the medical curriculum, resentment among undergraduates at the waste of time in conducting apparently fruitless experiments, and caustic criticism among graduates aimed at the teaching of isolated facts of undemonstrable utility, it may not be amiss to examine some of the conditions toward which adverse comment is directed. Possibly the irritation felt has a justification; possibly the curriculum might be light ened and improved by clearing away the relatively unessential and placing more emphasis on data of unquestioned adaptability. That such a clarifying investigation might be profitably conducted in nearly every branch of medical teaching seems to be generally believed by the practicing profession. The present discussion, however, must be limited in subjectmatter principally to laboratory physiology. As a brief preliminary, it should be accepted as axiomatic that the matriculant in medicine is thereby a self-limited specialist. He
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1–ErbB4 and DISC1
Authors: Hanna Jaaro-Peled, Akiko Hayashi-Takagi, Saurav Seshadri, Atsushi Kamiya, Nicholas J. Brandon, Akira Sawa
Journal: Trends in Neurosciences (2009)
Study of the Patients’ Difficulties in Ending Brief Psychoanalytic Psychotherapy
Authors: Grigoris Vaslamatzis, Marios Markidis, Klea Katsouyanni
Journal: Psychotherapy and Psychosomatics (1989)

Brief psychotherapy implies a limitation of the time needed, which should meet both the patient's acceptance and the therapist's awareness. However, some patients have difficulties in ending therapy. The material of this study consists of 27 patients. Of these patients, 5 dropped out in the termination phase, while for another 8 it became apparent a little before or after the final phase that psychotherapy would have to be continued. The results of the statistical analysis – factor analysis and analysis of variance for the investigation of therapists' difficulties, and discriminant analysis to assess differences concerning the suitability of patients for brief psychotherapy – showed that: (1) the less a therapist feels self-confident, the more likely his/her patient is to break off therapy at the termination point, and (2) the suitability score, determined during evaluation, emerges as the main differentiating parameter of the three groups (dropouts, continuers, completers).
THE INFLUENCE OF INJECTIONS OF HOMOLOGOUS HEMOGLOBIN ON THE KIDNEYS OF NORMAL AND DEHYDRATED ANIMALS
Authors: Joseph J. Lalich
Journal: The Journal of Experimental Medicine (1947)

1. Dehydration, if sufficiently prolonged, favors the accumulation of hemoglobin or its derivatives in the kidneys of rabbits, principally casts formed in the distal convoluted tubules. 2. Once pigment casts have been produced in the distal convoluted tubules, there is obstruction, with atrophy and dilatation of the tubules proximal to the obstruction. 3. When the involvement is sufficiently extensive, there is elevation of the non-protein nitrogen and some animals die because of renal failure.
CELLULAR HYPERSENSITIVITY TO ORAL LICHEN PLANUS LESIONS <i>IN VITRO</i>
Authors: P. HOLMSTRUP, W. SØBORG
Journal: Allergy (1977)

The purpose of the present investigation was to demonstrate in vitro cellular hypersensitivity to oral lichen planus lesions. Twenty oral lichen planus patients and 20 control persons matched by and sex were examined by the leukocyte migration agarose technique with tissue extracts from oral lichen planus lesions, normal oral mucosa and normal human kidney, the two latter extracts serving as control antigens. The female lichen planus patients showed statistically significant (P=0.004) migration inhibition with extracts from oral lichen planus lesions, which supports the hypothesis of cellular hypersensitivity to oral lichen planus lesions. However, the male lichen planus patients did not show any significant reaction. No significant reaction was found with the control antigens. The findings do not exclude the hypothesis of cellular hypersensitivity to oral lichen planus lesions. Furthermore, they do not support the hypothesis of oral lichen planus being an autoimmune disease.
Continuing Education: Journal
Authors: Brenda Butka
Journal: Annals of Internal Medicine (2013)

Ad Libitum19 March 2013Continuing Education: JournalBrenda Butka, MDBrenda Butka, MDFrom Nashville, Tennessee.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-6-201303190-00013 Audio Reading - “Continuing Education: Journal” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Continuing Education: Journal," by B. Butka. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Looking at the EKGprinted here, I turn the page, thenturn back again.That flailing line is so small, almost nothing,a narrow mark across time, left behindas a few molecules move inside a cell and out, frantictraffic coming to a stopon a microscopic street. If ever Iwant a small calligraphy of death,there it is, and, over and over,I watch this man die.give the girl ... Author, Article, and Disclosure InformationAffiliations: From Nashville, Tennessee.Current Author Address: Brenda Butka, MD; e-mail, brenda.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Continuing Education: Journal” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Continuing Education: Journal," by B. Butka. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 19 March 2013Volume 158, Issue 6Page: 496KeywordsHeartHomicideLower back pain ePublished: 19 March 2013 Issue Published: 19 March 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
NEGLECTED FACTORS IN THE PREVENTION OF APORLEXY
Authors: H. H. DRYSDALE
Journal: JAMA (1924)

The achievements of preventive medicine during recent years have been truly epochal. The child of today finds itself surrounded by every conceivable health safeguard, and nothing is being left undone to raise the physical stability of the coming generation to the highest possible standard. From a health standpoint, our children, as never before, are being adequately equipped to meet the responsibilities that eventually must come to them. All this is commendable and highly desirable, but it should not end there. Does not the other extreme of life require the same special care and attention if the human machine is to continue in a state of efficiency for the greatest possible number of years? The preservation of health and the prolonging of life is therefore a highly important consideration, and this constitutes the subject of my thesis. Despite the fact that during the last century the average span of life has
Asymptomatic Coronary-Artery Spasm
Authors: Michele Hamon, Martial Hamon
Journal: New England Journal of Medicine (2006)

A 38-year-old man was scheduled to undergo invasive coronary angiography after cardiac scintigraphy revealed silent ischemia of the anterior myocardial wall. He was a smoker and had no other medical problems apart from occasional atypical chest pain. Coronary angiography showed chronic total occlusion of the proximal part of the left anterior descending coronary artery (LAD), clinically insignificant atherosclerotic plaque in the right coronary artery, and collateral circulation to the distal portion of the LAD. Treatment with a beta-blocker was begun, and the patient underwent multislice computed tomography (CT) of the coronary arteries 1 month later to better assess the distal . . .
FRACTURE OF THE PATELLA.
Authors: JAMES M. BARTON
Journal: JAMA (1901)

In fracture of the patella, where no operation is performed and ligamentous union is permitted to occur, as a rule, the result is far from satisfactory. Though the bones may be in close apposition at the termination of treatment, the tissue between the fragments soon stretches. The patient limps or is quite lame, is unfitted for any active exercise and, if in the army or navy, is permanently shelved. The fracture not infrequently recurs, and it is by no means unusual for the patella of the other leg to give way. It has been again and again claimed that by some new and ingeniously devised external apparatus, close, firm and lasting union has been obtained, without operation, but none of these claims has so far stood the test of time. We can not better show how all external treatment has failed than by quoting the method now advised by Da
Optimization of 3-D hepatocyte culture by controlling the physical and chemical properties of the extra-cellular matrices
Authors: Susanne Ng, Ying-Nan Wu, Yi Zhou, Yi-Er Toh, Zi-Zong Ho, Ser-Mien Chia, Jian-Hang Zhu, Hai-Quan Mao, Hanry Yu
Journal: Biomaterials (2004)
BRIEF LOW-WORKLOAD MYOCARDIAL ISCHEMIA INDUCES PROTECTION AGAINST INCREASED EXERCISE-RELATED PLATELET REACTIVITY IN PATIENTS WITH CORONARY ARTERY DISEASE
Authors: Gaetano A. Lanza, Giancarla Scalone, Ilaria Coviello, Gaetano Pinnacchio, Lucy Barone, Chiara Pisanello, Roberto Mollo, Priscilla Lamendola, Fabio Infusino, Filippo Crea
Journal: Journal of the American College of Cardiology (2010)
Is the Supply of Mammography Machines Outstripping Need and Demand?
Authors: Martin L. Brown
Journal: Annals of Internal Medicine (1990)

The number of dedicated mammography machines installed in the United States has grown explosively. It is estimated that almost 10,000 machines will be installed by 1990, whereas the projected demand for screening mammography will require only approximately 2,600 machines, if the machines are used in a moderately efficient manner. The excess supply of mammography resources raises concern from an economic perspective for several reasons. First, such a condition means that health care resources are being used inefficiently. Second, the low average utilization rate of mammography equipment implied by these results necessitates charging a high price-over $100, on average-to cover costs. This price is above the $50 usually associated with low-cost screening mammography programs, and it may impede a desirable public health trend to increase use of mammography screening. Third, the existence of many mammography facilities operating at low capacity levels is inefficient from a health systems perspective, increasing the cost of quality assurance and medical record keeping. The current condition of excess supply is probably unsustainable over the long term.
A useful tip for direct microscopy
Authors: S. Ogden, I.H. Coulson
Journal: British Journal of Dermatology (2006)

Journal Article A useful tip for direct microscopy Get access S. Ogden, S. Ogden Dermatology Department, Burnley General Hospital, Burnley, Lancashire, U.K.E‐mail: stephanie.ogden@ntlworld.com Search for other works by this author on: Oxford Academic Google Scholar I.H. Coulson I.H. Coulson Dermatology Department, Burnley General Hospital, Burnley, Lancashire, U.K.E‐mail: stephanie.ogden@ntlworld.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 2, 1 February 2007, Page 394, https://doi.org/10.1111/j.1365-2133.2006.07644.x Published: 01 February 2007
Differential Effects of Captopril and Nitrates on Muscle Sympathetic Nerve Activity in Volunteers
Authors: Georg Noll, René R. Wenzel, Stefano de Marchi, Sidney Shaw, Thomas F. Lüscher
Journal: Circulation (1997)

The sympathetic nervous system (SNS) is an important regulator of cardiovascular function. Activation of SNS plays an important role in the pathophysiology and the prognosis of cardiovascular diseases such as heart failure, acute coronary syndromes, arrhythmia, and possibly hypertension. Vasodilators such as adenosine and sodium nitroprusside are known to activate SNS via baroreflex mechanisms. Because vasodilators are widely used in the treatment of patients with cardiovascular diseases, the aim of the present study was to assess the influence of clinically used dosages of isosorbide dinitrate and captopril on sympathetic nerve activity at rest and during stimulatory maneuvers.Twenty-eight healthy volunteers were included in this double-blind placebo-controlled study, and muscle sympathetic nerve activity (MSA; with microelectrodes in the peroneal nerve), blood pressure, heart rate, and neurohumoral parameters were measured before and 90 minutes after the oral administration of 40 mg isosorbide dinitrate or 6.25 mg captopril. Furthermore, a 3-minute mental stress test and a cold pressor test were performed before and 90 minutes after drug administration. Resting MSA did not change after captopril and decreased compared with placebo (P < .05 versus placebo), whereas isosorbide dinitrate led to a marked increase in MSA (P < .05). Systolic blood pressure was reduced by isosorbide dinitrate (P < .05), whereas captopril decreased diastolic blood pressure (P < .05). The increases in MSA, blood pressure, and heart rate during mental stress were comparable before and after drug administration regardless of the medication. During cold pressor test, MSA and systolic and diastolic blood pressures increased to the same degree independent of treatment, but after isosorbide dinitrate, the increase in MSA seemed to be less pronounced. Heart rate did not change during cold stimulation. Plasma renin activity increased after captopril and isosorbide dinitrate (P < .05), whereas placebo had no effect. Endothelin-1 increased after placebo and isosorbide dinitrate (P < .05) but not after captopril.Thus, captopril suppressed MSA despite lowering of diastolic blood pressure but allowed normal adaptation of the SNS during mental or physical stress. In contrast, the nitrate strongly activated the SNS under baseline conditions. These findings demonstrate that vasodilators differentially interact with the SNS, which could be of importance in therapeutic strategies for the treatment of patients with cardiovascular diseases.
Xenotransplantation Workshop Ponders Science, Safety of Animal Tissue Grafts
Authors: Joan Stephenson
Journal: JAMA (1995)

SCIENTISTS say that improvements in transplantation in recent years have created such a demand for organs among desperately ill patients that xenotransplantation, most likely with tissue from nonhuman primates or, even likelier, pigs, is the only hope for easing the shortfall. For the most part, clinical scientists beat a hasty retreat back to the laboratory after surgeons in 1984 grafted a baboon heart into a 15-day-old infant. "Baby Fae" lived just 20 days before her body rejected the animal organ. But the controversy surrounding the case lingered far longer, and transplant surgeons, aware of the then-insurmountable problem of immune rejection of animal organs, largely refrained from attempting similar procedures. In the decade or so since that operation, however, enormous strides in understanding the immune system and in genetic engineering technology-coupled with the increasing demand of thousands of patients waiting in vain for a suitable organ—have thrust xenotransplantation back into the
LIME
Authors: Naděžda Brdičková, Tomáš Brdička, Pavla Angelisová, Ondrej Horváth, Jiří Špička, Ivan Hilgert, Jan Pačes, Luca Simeoni, Stefanie Kliche, Camilla Merten, Burkhart Schraven, Václav Hořejší
Journal: The Journal of Experimental Medicine (2003)

Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck-interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. Thus, LIME appears to be involved in regulation of T cell activation by coreceptors.
Barium-Enema Study of Postoperative Recurrences of Carcinoma of the Colon
Authors: Colvin H. Agnew
Journal: JAMA (1962)

From 574 patients with carcinoma of the colon, 111 anastomotic sites have been reviewed. After 3 months the appearance of the colonic anastomosis is well stabilized. The first postoperative barium enema examination will serve as a baseline appearance for future comparison and should be done approximately 3 months following surgery. The distinction between a normal anastomosis and a recurrence may hinge upon the demonstration of minor changes of length of narrowing or caliber of lumen. The high incidence of second, new primary lesions must alert the radiologist to a meticulous examination of the entire remaining colon. Limited air barium contrast studies will provide the sharpest roentgenograms of the anastomosis on the left side.
The orderly output constraint is not wearing any clothes
Authors: Carol A. Fowler
Journal: Behavioral and Brain Sciences (1998)

The orderly output constraint (OOC) is extraneous. Talkers “speak in lines” in its absence. Further, there is no perceptual motivation for an OOC; perceivers ignore the linearity between F2 at consonant-vowel onset and F2 in the vowel. In any case, the analogy with bat and barn owl localization systems underlying the theory is extreme, Sussman et al.'s comments to the contrary notwithstanding.
Birth Control by Intrauterine Devices
Authors: Frank N. Allan
Journal: JAMA (1969)

The recent warning concerning oral contraceptive drugs sent by direct mail from the Food and Drug Administration to all physicians in the nation pointed to the small but definite risk of thromboembolism. This has caused many to reconsider the merits of alternative contraceptive measures. An excellent source of information about one of these can be found in the<i>Report on Intrauterine Contraceptive Devices</i><sup>*</sup>prepared by the Advisory Committee on Obstetrics and Gynecology of the Food and Drug Administration earlier this year. The report presents a concise but comprehensive review and also an excellent bibliography listing several hundred references. <h3>History</h3> Intrauterine devices (IUD) to prevent pregnancy were known to the ancients. In the past century they have been employed widely in various parts of the world. In this country, however, relatively little attention was given to the method until the present decade. Now the IUD is being used on a large
Continuing Stability of Center Differences in Pediatric Diabetes Care: Do Advances in Diabetes Treatment Improve Outcome? The Hvidoere Study Group on Childhood Diabetes
Authors: Stuart Chalew
Journal: Diabetes Care (2008)

The Hvidoere Study Group is to be commended for their efforts to elucidate demographic, ethnic, and treatment factors associated with disparities in mean A1C that persisted between participating pediatric diabetes clinics despite similar treatment goals and management techniques (1). It was disheartening that none of the evaluated factors, with the possible exception of language difficulties, yielded an easy-to-implement way to improve mean A1C levels within clinics or reduce A1C differences between clinics.

The authors mention that two clinics markedly improved their mean clinic A1C and hint that improvement may have been …
Dalteparin was at least as effective as UFH for VTE prevention in critically ill patients, with similar costs
Authors: Stephen M. Pastores, Maria T. DeSancho
Journal: Annals of Internal Medicine (2015)

Source Citation Fowler RA, Mittmann N, Geerts W, et al; Canadian Critical Care Trials Group; Australia and New Zealand Intensive Care Society Clinical Trials Group. Cost-effectiveness of dalteparin vs unfractionated heparin for the prevention of venous thromboembolism in critically ill patients. JAMA. 2014;312:2135-45. 25362228
The cardiac ryanodine receptor (calcium release channel) Emerging role in heart failure and arrhythmia pathogenesis
Authors: M Scoote
Journal: Cardiovascular Research (2002)

The cardiac sarcoplasmic reticulum calcium release channel, commonly referred to as the ryanodine receptor, is a key component in cardiac excitation–contraction coupling, where it is responsible for the release of calcium from the sarcoplasmic reticulum. As our knowledge of the ryanodine receptor has advanced an appreciation that this key E–C coupling component may have a role in the pathogenesis of human cardiac disease has emerged. Heart failure and arrhythmia generation are both pathophysiological states that can result from deranged excitation–contraction coupling. Evidence is now emerging that hyperphosphorylation of the cardiac ryanodine receptor is an important event in chronic heart failure, contributing to impaired contraction and the generation of triggered ventricular arrhythmias. Furthermore the therapeutic benefits of β blockers in heart failure appear to be partly explained through a reversal of this phenomenon. Two rare inherited arrhythmogenic conditions, which can cause sudden death in children, have also been shown to result from mutations in the cardiac ryanodine receptor. These conditions, catecholaminergic polymorphic ventricular tachycardia and arrhythmogenic right ventricular cardiomyopathy (subtype 2), further implicate the ryanodine receptor as a potentially arrhythmogenic substrate and suggest that this channel may offer a new therapeutic target in the treatment of both cardiac arrhythmias and heart failure.
Polycythemia Vera, the Hematocrit, and Blood-Volume Physiology
Authors: Jerry L. Spivak
Journal: New England Journal of Medicine (2012)

Marchioli et al.1 report in the Journal that a hematocrit target of less than 45% for therapeutic phlebotomy reduces the risk of thrombosis in patients with polycythemia vera. In the genomic era, readers may question attention given to a measurement as mundane as the hematocrit, but this study resolves a half-century of debate about the role of phlebotomy in polycythemia vera and has ramifications for diagnosis and management.Polycythemia vera is a unique myeloproliferative disorder in which there is overproduction of morphologically normal erythrocytes, granulocytes, and platelets, a phenotype that is caused by a mutation (V617F) in JAK2, encoding a . . .
In defense of neuro-perceptual isomorphism
Authors: Dejan Todorović
Journal: Behavioral and Brain Sciences (1998)

It is argued that the notion of bridge locus is compatible with distributed representation and brain interconnectivity. Isomorphism is not a dogmatic condition on explanatory adequacy but a refutable hypothesis, superior to Dennett's proposed alternatives. The assumption of type-type neuro-perceptual correspondences is more parsimonious than multiple realizability.