Cerebral Gigantism with Intermittent Fractional Hypopituitarism and Normal Sella Turcica
Authors: GEORGE D. LUDWIG
Journal: Annals of Internal Medicine (1967)

Case Studies1 July 1967Cerebral Gigantism with Intermittent Fractional Hypopituitarism and Normal Sella TurcicaGEORGE D. LUDWIG, M.D., F.A.C.P., LOUIS B. CHAYKIN, M.D., ANTONIO V. ESCUETA, M.D.GEORGE D. LUDWIG, M.D., F.A.C.P.Search for more papers by this author, LOUIS B. CHAYKIN, M.D.Search for more papers by this author, ANTONIO V. ESCUETA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-123 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA syndrome of cerebral gigantism with normal sella turcica occurring in childhood has recently been described by Sotos and co-workers (1). In all of their patients the growth spurt leading to gigantism appeared to take place during the first 4 years of life, probably beginning before birth, since the birth length was between the ninetieth and the ninety-seventh percentiles in all and the birth weight was between these percentiles in three of the five cases. These children displayed acromegalic features and a nonprogressive cerebral disorder with mental retardation. Two of the five had convulsive seizures.A somewhat similar syndrome, consisting...References1. SOTOSDODGEMUIRHEADCRAWFORDTALBOT JFPRDJDNB: Cerebral gigantism in childhood. A syndrome of excessively rapid growth with acromegalic features and a nonprogressive neurologic disorder. New Eng. J. Med. 271: 109, 1964. CrossrefMedlineGoogle Scholar2. GOLDMANCAHILLTHORN JKGFGW: Gigantism with hypopituitarism. Amer. J. Med. 34: 407, 1963. CrossrefMedlineGoogle Scholar3. SARVERSABEHFETTERMANWALDDANOWSKI MEGGHNTS: Fractional hypopituitarism with giantism and normal sella turcica. New Eng. J. Med. 271: 1286, 1964. CrossrefMedlineGoogle Scholar4. OPPENHEIMERFISHERNELSONJAILER JHLVKMJW: Depression of the serum protein-bound iodine level by diphenylhydantoin. J. Clin. Endocr. 21: 252, 1961. CrossrefMedlineGoogle Scholar5. SPARBERG M: Diagnostically confusing complications of diphenylhydantoin therapy. A review. Ann. Intern. Med. 59: 914, 1963. LinkGoogle Scholar6. JONXISSMITHHUISMAN JHPATH: Rickets and amino-aciduria. Lancet 2: 1015, 1952. CrossrefMedlineGoogle Scholar7. JONXIS JH: Amino-aciduria and rickets. Helv. Paediat. Acta 10: 245, 1955. MedlineGoogle Scholar8. LIDDLEESTEPKENDALLWILLIAMSTOWNES GWHLJWWCAW: Clinical application of a new test of pituitary reserve. J. Clin. Endocr. 19: 875, 1959. CrossrefMedlineGoogle Scholar9. WOLFFADLERBUSKIRKTHOMPSON SMRCERRH: A syndrome of periodic hypothalamic discharge. Amer. J. Med. 36: 956, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Departments of Medicine and Neurology, University of Pennsylvania, Philadelphia, Pa.This work was supported in part by grant 3M01 FR-40, Clinical Research Center, Division of Research Facilities and Resources, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to George D. Ludwig, M.D., Hospital of the University of Pennsylvania, 3600 Spruce St., Philadelphia, Pa. 19104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCerebral gigantism syndromeCerebral Gigantism—Inappropriate Secretion of Growth Hormone?WILL G. RYAN, M.D. 1 July 1967Volume 67, Issue 1Page: 123-131KeywordsBirthBirth weightChild healthChildrenEpileptic seizuresIntellectual disabilityNeurologyResearch facilities Issue Published: 1 July 1967 PDF DownloadLoading ...