Anti-Insulin Receptor Antibodies and Diabetes
Authors: William G. Blackard, James H. Anderson, Franklin Mullinax
Journal: Annals of Internal Medicine (1977)

Letters1 May 1977Anti-Insulin Receptor Antibodies and DiabetesWILLIAM G. BLACKARD, M.D., JAMES H. ANDERSON, M.D., FRANKLIN MULLINAX, M.D.WILLIAM G. BLACKARD, M.D.Search for more papers by this author, JAMES H. ANDERSON, M.D.Search for more papers by this author, FRANKLIN MULLINAX, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-5-584 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1970 we reported the spontaneous remission of severe insulin-resistant diabetes mellitus in a patient with features of scleroderma (1). We now report the apparent cause of this patient's insulin resistance. Serum samples taken during the period of insulin resistance contain immunoglobulin (Ig) G antibodies that block cellular receptors for insulin. Samples taken during remission do not contain these antireceptor antibodies. Our patient is similar to three others reported with severe insulin resistance, antibodies to insulin receptors, and associated features of an immunologic disease (2, 3). However, our patient is unique in that she underwent a spontaneous remission of her...References1. BRUCEBERNARDBLACKARD DWW: Spontaneous disappearance of insulin-resistant diabetes mellitus in a patient with a collagen disease. Am J Med 48:268-272, 1970 CrossrefMedlineGoogle Scholar2. FLIERKAHNROTH JCJ: Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science 190:63-65, 1975 CrossrefMedlineGoogle Scholar3. KAHNFLIERBAR CJR: The syndromes of insulin resistance and acanthosis nigricans. N Engl J Med 294:739-745, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByExcess Insulin Binding to Insulin-Like Growth Factor Receptors: Proposed Mechanism for Acanthosis NigricansAntibodies directed to the insulin receptor. Clinical aspects and applications to the study of insulin actionAcanthosis nigricans: A cutaneous marker of tissue resistance to insulinHyperalimentation as cause of markedly worsened metabolic control in a patient with autoantibodies to the insulin receptorLupus Nephritis and Other Autoimmune Features in Patients with Diabetes Mellitus Due to Autoantibody to Insulin ReceptorsGEORGE C. TSOKOS, M.D., PHILLIP GORDEN, M.D., TATIANA ANTONOVYCH, M.D., CURTIS B. WILSON, M.D., JAMES E. BALOW, M.D.Antireceptor AntibodiesA connective tissue disease complicated by insulin resistance due to receptor antibodies: Report of a case with high titer nuclear ribonucleoprotein antibodiesDiabetes Mellitus Caused by Insulin-Receptor Blockade and Impaired Sensitivity to InsulinReceptor dysfunctions in human diseasePrinciples of Membrane Receptor Physiology and Their Application to Clinical MedicineROBERT J. POLLET, M.D., Ph.D., GERALD S. LEVEY, M.D.Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricansInsulin resistance due to receptor antibodies: a complication of progressive systemic sclerosisTreatment by Plasma Exchange of a Patient with Autoantibodies to the Insulin ReceptorReceptors, Antireceptor Antibodies and Mechanisms of Insulin ResistanceCell Receptors in Disease 1 May 1977Volume 86, Issue 5Page: 584-585KeywordsAntibodiesDiabetes mellitusInsulinInsulin resistanceScleroderma Issue Published: 1 May 1977 PDF DownloadLoading ...