Effect of Splenectomy on Red Cell Production
Authors: ALLAN J. ERSLEV
Journal: Annals of Internal Medicine (1967)

Article1 November 1967Effect of Splenectomy on Red Cell ProductionALLAN J. ERSLEV, M.D., F.A.C.P., PATRICK J. MCKENNA, M.D.ALLAN J. ERSLEV, M.D., F.A.C.P., PATRICK J. MCKENNA, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-5-990 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn hereditary spherocytosis and in some cases of acquired hemolytic anemia splenectomy will remove the major site of red cell destruction and in turn increase the hemoglobin concentration and abolish the need for an accelerated rate of red cell production. In these conditions the immediate effect of splenectomy on red cell production is usually obscured by preoperative transfusions or by autotransfusions from the surgically manipulated spleen. The resulting increase in hemoglobin concentration would be expected to cause a prompt decrease in erythropoietic activity. In two recent cases, one of a patient with hereditary spherocytosis and the other of a patient...References1. PETERSON RE: Improved spectrophotometric procedure for determination of serum iron using 4.7-diphenyl-1,10, phenonthroline. Anal. Chem. 25: 1337, 1953. CrossrefGoogle Scholar2. BOTHWELLHURTADODONOHUEFINCH THAVDMCA: Erythrokinetics. IV. The plasma iron turnover as a measure of erythropoiesis. Blood 12: 409, 1957. CrossrefMedlineGoogle Scholar3. ROSSEWALDMANN WFTA: Bioassays of erythropoietin. A. Method using transfused polycythemic mice, in Hemoglobin: Its Precursors and Metabolites, edited by SUNDERMAN, F. W., SUNDERMAN, F. W., JR. J. B. Lippincott Co., Philadelphia, 1964, p. 269. Google Scholar4. JACOBSONGOLDWASSERGURNEY LOECW: Control of red cell formation, in The Kinetics of Cellular Proliferation, edited by STOHLMAN, F., JR. Grune & Stratton, Inc., New York, 1959, p. 344. Google Scholar5. ERSLEV AJ: The role of erythropoietin in the control of red cell production. Medicine (Balt.) 43: 661, 1964. CrossrefMedlineGoogle Scholar6. BROWNALTSCHULERCOOPER JRNJA: Erythropoietic effect of red cell components and heme-related compounds. Proc. Soc. Exp. Biol. Med. 112: 840, 1963. CrossrefMedlineGoogle Scholar7. SANCHEZ-MEDALLABARDINILORIA LJA: Hemolysis and erythropoiesis. I. Influence of intraperitoneal administration of whole hemolysates on the recovery of bled dogs, as measured by changes in the total erythrocytic volume. Blood 21: 586, 1963. MedlineGoogle Scholar8. POLLYCOVE M: Iron metabolism and kinetics. Seminars Hemat. 3: 235, 1966. MedlineGoogle Scholar9. CRUZHAHNBALE WOPFWF: Hemoglobin radioactive iron liberated by erythrocyte destruction (acetyl phenylhydrazine) promptly reutilized to form new hemoglobin. Amer. J. Physiol. 135: 595, 1942. CrossrefGoogle Scholar10. JACOBMACDONALDJANDL HSRAJH: Regulation of spleen growth and sequestering function. J. Clin. Invest. 42: 1476, 1963. CrossrefMedlineGoogle Scholar11. FELDTHUSENLARSENLASSEN UVNA: Serum iron and operative stress. Acta Med. Scand. 147: 311, 1953. CrossrefMedlineGoogle Scholar12. BAIRDPADMOREWILSON JMDAGM: Changes in iron metabolism following gastrectomy and other surgical operations. Clin. Sci. 16: 463, 1957. MedlineGoogle Scholar13. CARTWRIGHT GE: The anemia of chronic disorders. Seminars Hemat. 3: 351, 1966. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALLAN J. ERSLEV, M.D., F.A.C.P.; PATRICK J. MCKENNA, M.D.Affiliations: Philadelphia, PennsylvaniaFrom the Cardeza Foundation, Jefferson Medical College, Philadelphia, Pa.This study was supported in part by grants H-4612 and H-6374 and clinical research grant FR-72, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Allan J. Erslev, M.D., 1015 Sansom St., Philadelphia, Pa. 19107. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOral ferroportin inhibitor vamifeport for improving iron homeostasis and erythropoiesis in β-thalassemia: current evidence and future clinical developmentCase 1—1993 The role of erythropoietin in Jehovah's Witnesses requiring cardiac surgeryThe anemia of inflammatory disease in the dog I. The nature of the problemRole of iron as a regulator of thrombopoiesisRed cell production and ferrokinetics in the puerperiumThe Spleenless State in ManTHE IMPORTANCE OF IRON SUPPLY IN THALASSEMIC ERYTHROPOIESIS 1 November 1967Volume 67, Issue 5Page: 990-997KeywordsAttentionHemoglobinHemolytic anemiaResearch grantsSpleenSplenectomy ePublished: 1 December 2008 Issue Published: 1 November 1967 PDF downloadLoading ...