Furosemide Challenge in Patients with Heart Failure and Adverse Reactions to Sulfa-Containing Diuretics
Authors: Grace Earl, James Davenport, Jagat Narula
Journal: Annals of Internal Medicine (2003)

Letters18 February 2003Furosemide Challenge in Patients with Heart Failure and Adverse Reactions to Sulfa-Containing DiureticsGrace Earl, PharmD, James Davenport, MD, and Jagat Narula, MD, PhDGrace Earl, PharmDUniversity of the Sciences in Philadelphia; Philadelphia, PA 19104 (Earl)Drexel University College of Medicine; Philadelphia, PA 19102 (Davenport, Narula), James Davenport, MDUniversity of the Sciences in Philadelphia; Philadelphia, PA 19104 (Earl)Drexel University College of Medicine; Philadelphia, PA 19102 (Davenport, Narula), and Jagat Narula, MD, PhDUniversity of the Sciences in Philadelphia; Philadelphia, PA 19104 (Earl)Drexel University College of Medicine; Philadelphia, PA 19102 (Davenport, Narula)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-4-200302180-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Diuretics have an important role in managing symptomatic fluid overload in severe heart failure and are used in 85.8% of patients (1). Two patients in our 500-patient practice had reported a distant history of an adverse reaction to sulfa-containing diuretics and had been successfully managed with oral ethacrynic acid. However, the recent discontinuation of ethacrynic acid tablets by the manufacturer (Merck & Co., West Point, Pennsylvania) created a dilemma in managing these patients.Objective: We performed a MEDLINE search using the terms furosemide, bumetanide, torsemide, diuretics, sulfamyl diuretics, thiazide diuretics, hypersensitivity, allergy, and allergic reaction but ...References1. Cohn JN, Tognoni G, Glazer R, Spormann D. Baseline demographics of the Valsartan Heart Failure Trial. Val-HeFT Investigators. Eur J Heart Fail. 2000;2:439-46. [PMID: 11113722] CrossrefMedlineGoogle Scholar2. Absar N, Daneshvar H, Beall G. Desensitization to trimethoprim/sulfamethoxazole in HIV-infected patients. J Allergy Clin Immunol. 1994;93:1001-5. [PMID: 8006304] CrossrefMedlineGoogle Scholar3. Lasix [package insert]. Bridgewater, NJ: Aventis Pharmaceuticals; 2001. Google Scholar4. Bumex [package insert]. Basel, Switzerland: Roche; 2001. Google Scholar5. Demadex [package insert]. Basel, Switzerland: Roche; 2001. Google Scholar6. Byrd DR, Ahmed I. Photosensitive lichenoid reaction to torsemidea loop diuretic. Mayo Clin Proc. 1997;72:930-1. [PMID: 9379695] MedlineGoogle Scholar7. Hansbrough JR, Wedner HJ, Chaplin DD. Anaphylaxis to intravenous furosemide. J Allergy Clin Immunol. 1987;80:538-41. [PMID: 3668117] CrossrefMedlineGoogle Scholar8. Hunt SA, Baker DW, Chin MH, Cinquegrani MP, Feldman AM, Francis GS, . ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to revise the 1995 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol. 2001;38:2101-13. [PMID: 11738322] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Grace Earl, PharmD; James Davenport, MD; Jagat Narula, MD, PhDAffiliations: University of the Sciences in Philadelphia; Philadelphia, PA 19104 (Earl)Drexel University College of Medicine; Philadelphia, PA 19102 (Davenport, Narula) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCutaneous Adverse Events Caused by Sulfonamide-Containing Drugs: Reality or Perception?FurosemideThiazide diureticsSulfonamide cross-reactivity: Is there evidence to support broad cross-allergenicity?Four nephrology myths debunkedAdverse immunological effects of drugs other than anticance drugs and drugs used in immunologyRAPID ORAL DESENSITIZATION TO FUROSEMIDEDIURETICSAllergies to sulfonamide antibiotics and sulfur-containing drugsThe pharmacologic spectrum of furosemideAcute Heart FailureDesensitization therapy in a patient with furosemide allergyHydrochlorothiazide-induced angioedema in a patient allergic to sulfonamide antibiotics: Evidence from a case report and a review of the literatureSulfonamide Allergies and Outcomes Related to Use of Potentially Cross-Reactive Drugs in Hospitalized PatientsFurosemideThiazide diureticsProbable Loop Diuretic–Induced Pancreatitis in a Sulfonamide-Allergic PatientA Successful Rapid Desensitization Protocol in a Loop Diuretic Allergic PatientDiureticsCurrent awareness: Pharmacoepidemiology and drug safetyDiurétiques et vasodilatateurs 18 February 2003Volume 138, Issue 4Page: 358-359KeywordsAdverse reactionsAllergy and immunologyAnaphylaxisDiureticsDrugsHeart failureHypersensitivityPlateletsRashesUrticaria ePublished: 18 February 2003 Issue Published: 18 February 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...