tbuckley/cabot-search huggingface dataset:
Registering Results From Clinical Trials—Reply
Authors: James Dabney Miller
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor
Authors: Nina Reinart, Phuong-Hien Nguyen, Jorge Boucas, Natascha Rosen, Hans-Michael Kvasnicka, Lukas Heukamp, Cornelia Rudolph, Vangica Ristovska, Tanja Velmans, Carolin Mueller, Katrin S. Reiners, Elke Pogge von Strandmann, Günter Krause, Manuel Montesinos-Rongen, Brigitte Schlegelberger, Marco Herling, Michael Hallek, Günter Fingerle-Rowson
Journal: Blood (2012)
Surgical Stabilization of the Skeleton of the Hand
Authors: Kingsbury G. Heiple
Journal: JAMA (1978)

This small volume is another of the series extending to the hand the internal fixation concepts of the Swiss Association for the Study of Internal Fixation. As such, it is a welcome addition to this literature. For the knowledgeable hand surgeon, this compendium of techniques and "how to" illustrations may prove very useful, for it contains many innovative "tricks and wrinkles." On the equally important level of "when to," this text falls far short of ideal. A number of illustrations show examples that reflect an extreme bias toward plating techniques and open reductions where few US surgeons would choose to operate. An extreme example of this is illustrated in Figures 77 a to d where a neck fracture of the fifth metacarpal is shown and has been treated with a T-plate and four screws resulting in a pseudarthrosis. The answer to this probably iatrogenic problem is an axial compression screw
Re: Constantijn H.J. Muselaers, Otto C. Boerman, Egbert Oosterwijk, Johannes F. Langenhuijsen, Wim J.G. Oyen, Peter F.A. Mulders. Indium-111–Labeled Girentuximab ImmunoSPECT as a Diagnostic Tool in Clear Cell Renal Cell Carcinoma. Eur Urol 2013;63:1101–6
Authors: John Samuel Banerji
Journal: European Urology (2013)
AN ILEOSTOMY CLUB
Authors: Albert S. Lyons
Journal: JAMA (1952)

<h3>To the Editor:</h3> —In recent years heightened interest in the surgical treatment of ulcerative colitis has led to an ever-increasing group of patients with a permanent ileostomy. Most lay persons, as well as all too many physicians and surgeons, have a horror image of the constantly discharging intestinal stoma and frequently think, out of ignorance, that death is preferable to ileostomy. It is therefore extremely important for the person who has undergone ileostomy to have before him the evidence that adjustment can be made and the constant reminder that he is not so unfortunate as he might have imagined. Nothing is more effective in bolstering morale than the presence of happy persons with the same handicap carrying on normal existence, unabashedly attacking the specific problems that the handicap may cause. During the past one and one-half years at the Mt. Sinai Hospital we have had a club meeting once a
Foetal Blood Sampling. Practical Approach to Management of Foetal Distress
Authors: T. M. Coltart, N. R. A. Trickey, R. W. Beard
Journal: BMJ (1969)

The practical application of foetal blood sampling in the routine management of patients in labour has been reviewed in a six-month survey, during which time 1,668 patients were delivered at Queen Charlotte's Hospital.Foetal acidaemia (pH 7.25 or less) occurred in 45 of the 295 patients who showed clinical signs of foetal distress. Foetal tachycardia was the presenting sign in 33 of these 45 patients, underlining the importance of this physical sign. Foetal acidaemia in association with clinical foetal distress occurred twice as often in patients who had complications of pregnancy and who were therefore regarded as obstetrically "at risk" as it did in patients who were obstetrically "normal" No cases of acidaemia were detected in any of the foetal blood samples performed routinely on "at-risk" patients in the absence of clinical foetal distress.
OPHTHALMIA NEONATORUM.Read before the Cambridge Medical Improvement Society.
Authors: AUGUSTUS P. CLARKE
Journal: JAMA (1894)

Among the duties and responsibilities which the obstetrician has in large measure to assume, is the treatment of cases of ophthalmia occurring in the newborn. The disease is by no means infrequent; its course and termination have so often resulted unfavorably that public attention has been directed to the consideration of the subject. Perhaps it would not be unsafe to say that upward of 40 per cent. of all cases of total blindness has had its origin in this condition. The affection seems to be caused by acrid or septic discharges from the mother's tissues, coming in contact witn the eye of the fetus during its descent or expulsion from the vulvo-vaginal outlet. The stimulus of light to the infant's eyes may be an exciting cause in those cases in which a purulent or gonorrheal infection is present. Sometimes other agencies may lend their influence in exciting inflammation; want of
Workshop to identify critical windows of exposure for children's health: cardiovascular and endocrine work group summary.
Authors: M Barr, J M DeSesso, C S Lau, C Osmond, S E Ozanne, T W Sadler, R A Simmons, B R Sonawane
Journal: Environmental Health Perspectives (2000)

The work group on cardiovascular and endocrine effects was asked to review the current state of knowledge about children's windows of vulnerability to developmental toxicants and to recommend how that information may be used to improve risk assessment and public health. We considered differences between structural defects, where periods of vulnerability are rather well defined, and functional defects, where periods of vulnerability are quite elusive.
Allergenicity of varieties of soybean
Authors: R. Codina, L. Ardusso, R. F. Lockey, C. Crisci, I. Medina
Journal: Allergy (2003)

Background: Soybean hulls (SHs) cause respiratory allergies. This study investigates the allergenicity of soybean varieties (SVs) by in vivo and in vitro tests. Methods: Ten SVs were studied: (a) five with a proved clinical relevance (SVs 1, 2, 3, 4, 5), the last four with a ‘dull’ phenotype; (b) five of undetermined relevance, three of them (SVs 6, 7, 8) with a ‘shiny’ phenotype, and two (SVs 9 and 10) with a ‘dull’ phenotype. Extracts from all 10 SVs were used to skin prick test (SPT) 21 subjects sensitized to SHs. Positive and negative sera pools prepared from sera of subjects sensitized or not to SHs, respectively, were utilized to perform in vitro experiments (specific IgE and IgG4 determinations, SDS‐PAGE/IgE‐Western blot, and IgE‐inhibition). Results: In this study, it was found that 52.4, 52.4, 57.1, 71.4, 80.9, 42.9, 57.1, 71.4, 52.4, and 38.1% subjects had a positive SPT with SVs 1–10, respectively ( P NS). Specific IgE values to SVs 1–10 obtained with the positive pool are 28.3, 26.4, 29.9, 28.3, 26.8, 4.8, 13.4, 6.7, 24.7, and 17.5% total counts bound, respectively; and specific IgG4 values 0.851, 0.818, 0.721, 1.609, 0.789, 0.617, 0.662, 0.0, 1.127, and 0.934 OD units, respectively; the microgram of protein required to produce 50% inhibition are 2.5, 3.7, 4.5, 2.4, 5, 39.8, 25.2, 25.1, 4.5, and 8.9, respectively. A 7‐kDa band is present in all SVs except in those with a ‘shiny’ phenotype. Conclusions: The SVs with a ‘shiny’ phenotype contain less allergens than the other SVs studied, as determined by in vitro tests. However, SPT results with the SVs do not differ. Genetic screens should be devised to select plants with reduced, preferably absent, allergenicity, but with a high nutritional value, and this allergenicity should be studied utilizing in vivo and in vitro tests.
The Etiology and Pathogenesis of Oral Cancer
Authors: R. W. Osterkamp, J. B. Whitten
Journal: CA A Cancer Journal for Clinicians (1973)

The etiology of oral cancer in man is unknown.However, several pre-exist ing conditions have been found with such frequency in patients with oral cancer that they may be considered, at least in part.as contributory factors.For instance, chronic irritation seems to be related to the development of cancer, whereas a single episode of trauma does not.Other factors which may lead to the development of oral cancer include: El Ionizing radiation at therapeutic, not diagnostic, dosage levels.Fortunately, because of stricter rad iotherape utic guidelines, few patients are today ex posed to sufficient quantities of ionizing radiation to produce cancers of the oral cavity.El Chronic exposure to actinic radia tion.Chronic exposure to the sun is a significant factor in the development of cancer of the lower lip, the most com mon form of oral cancer.The high inci dence of â€oe¿ Farmer's lipâ€• and â€oe¿ Sailor's lip,â€• as well as epidermoid carcinoma of the lip in hot climates attests to the etiologic significance of long-term expo sure to sunlight.Apparently, repeated exposure to ultraviolet solar rays over a period of 15-30 years results in atrophic alterations of the exposed aspect of the lower lip, which may develop into car cinoma.The carcinogenic action of solar rays varies according to intensity
A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity
Authors: Akira Hayashi, Hisashi Wakita, Tomoaki Yoshikawa, Tsuyoshi Nakanishi, Yasuo Tsutsumi, Tadanori Mayumi, Yohei Mukai, Yasuo Yoshioka, Naoki Okada, Shinsaku Nakagawa
Journal: Journal of Controlled Release (2006)
1119-94 Reduced functional capacity in women is associated with impaired vascular function
Authors: Eileen Handberg, B.Delia Johnson, Christopher B Arant, Timothy R Wessel, Marian B Olson, Steven E Reis, Leslee Shaw, Sunil Mankad, William J Rogers, C.Noel Bairey Merz, George Sopko, Carl J Pepine
Journal: Journal of the American College of Cardiology (2004)
A CASE OF SUSPECTED RABIES WITH ISOLATION OF BACILLUS DIPHTHERIÆ FROM THE CENTRAL NERVOUS SYSTEM
Authors: George Douglas Head, Louis Blanchard Wilson
Journal: The Journal of Experimental Medicine (1899)

A Case of S~spected Rabiestwo days ago as a mild aching and numbness in that region and has been gradually growing more severe.There is little swelling and only slight tenderness on pressure over the area of pain.There is complaint of some difficulty in opening the mouth owing to pain in the temporomaxillary articulation.Patient complains of loss of sleep.Temperature 98.8 ° F. Pulse 100.Diagnosis: facial neuralgia.Treatment: phenacetine and salicylates.Dec. 4. Patient at office.Tenderness most marked over the site of the bite.Pain paroxysmal in character, running along the ramns of lower jaw, up the side of head, in front and back of left ear, and back along the left sternocleidomastoid muscle.As patient complains of difficulty in swallowing I give her a glass of water to drink.She raises the glass to her lips, gives a short, jerky inspiration, and swallows the liquid.Suspecting rabies, I call Dr. Hunter in consultation.Patient carefully examined.No throat lesions.No decayed teeth.No ear trouble.Tenderness sharply localized over the area supplied by middle branch of fifth nerve.Temp.99.4 ° .Diagnosis: neuralgia of middle branch of fifth nerve or beginning rabies.Treatment, morphine.December 5. Fifth day of disease.Called at 4: a. m.Patient has spent a bad night with little sleep.Excruciating pain over same area as described.Mouth opened with more difficulty.Can swallow saliva, but if she attempts to drink water, tea or milk she takes a number of short, quick, catchy inspirations, her eyes start from her head, she looks wildly about, then swallows the fluid with a gulp.The swallowing seems a great effort and tires her.Temperatnre 99 °.Pulse 108.Heart, lungs, and abdomen normal.No enlarged spleen.Bowels constipated.Urine, acid, ]024.No albumin, or sugar.Urea 2.5 per cent.No casts, blood or leucocytes.Diagnosis: suspected rabies.December 5, 4 p.m. Patient resting easier.Laryngeal and respiratory spasms more pronounced, l~Tow even the taking of a glass of fluid into her hand causes a faint spasm.As she puts the liquid to her lips her hand will shake "dolently, the catchy inspirations will begin, and it seems almost impossible for her to swallow.She can swallow solids, though with some difficulty.With the exception of the laryngeal spasms and the pain, she seems perfectly normal.Sits up in a chair, talks with her friends, and is undisturbed mentally.Temperature 99.2 °.Pulse 110, irregular and rapid.Respirations normal December 6, 8 a. m.Drs.Hunter and Sweeney in consultation.Sleepless night, Has taken little nourishment and no fluids.Complains much of thirst.Bowels moved.Temperature 100 °.Pulse 110.
Is the poor sleep of shift workers a disorder?
Authors: Q R Regestein, T H Monk
Journal: American Journal of Psychiatry (1991)

The purpose of this article is to describe the impact of shift work on sleep, as recently acknowledged in official nosologies of sleep disorders, and to discuss whether sleep altered by shift work actually constitutes a disorder.The authors review subjective responses to recent survey questions about sleep and polygraphic measurements of sleep in shift workers and describe sleep clinic experiences with complaints related to shift work.Shift work entails wide variation in work schedules, sleep quality, and worker tolerance and a high prevalence of night-shift sleepiness. It probably affects rates of drug use, health status, and family organization. Clinical presentations were rare, highly varied, and empirically treated. The United States, unlike other countries, has no legal restrictions on shift work.As a clinical phenomenon, sleep altered by shift work is common and varied, probably expresses nonphysiological sleep-wake scheduling, and is little treated. Further study of its health effects and consideration of whether it is a "disorder" or a "problem" seem warranted.
Stress in Residency
Authors: George Wesley
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 October 1988Stress in ResidencyGeorge Wesley, MDGeorge Wesley, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-7-599 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In reviewing the report of the Resident Services Committee on stress and impairment in residency (1), I was reminded of the line attributed to the Israeli statesman, Abba Eban, "Consensus means that lots of people say collectively what nobody believes individually" (2). For, although certainly innocuous proposals, such as journal clubs, clear definition of expectations, and group social activities, are well taken and merit the enumeration so comprehensively provided in this report, the more central issue of "inordinate and inflexible time demands, fatigue, and sleep deprivation [that] are universally recognized as undesirable stresses of residency training," is...References1. . Stress and impairment during residency training: strategies for reduction, identification, and management. Ann Intern Med. 1988;109:154-61. LinkGoogle Scholar2. Los Angeles Times. 1988 July 28: 13. Google Scholar1. . Stress and impairment during residency training: strategies for reduction, identification, and management. Ann Intern Med. 1988;109:154-61. LinkGoogle Scholar2. Hilficker D. Facing our mistakes. N Engl J Med. 1984;310:118-22. CrossrefMedlineGoogle Scholar3. Katz J. The Abandonment of patients: a final argument against silence. In: The Silent World of Doctor and Patient. New York: The Free Press; 1985:207-12. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1988Volume 109, Issue 7Page: 599-600KeywordsFatigueMotivationResidencySleep deprivation Issue Published: 1 October 1988 PDF downloadLoading ...
The Low Frequency Velocity Measurement Ballistocardiograph
Authors: J. E. SMITH, SAMUEL BRYAN
Journal: Circulation (1952)

The velocity measurement ballistocardiograph is described which has filter circuits to eliminate body tremor components. Small adjustable condensers are utilized on the input and output of the filter section to vary the frequency response of the circuit and thus create a sharper cut-off for occasional cases with high amplitude body tremor. The input and output condenser values are not above 5 mfd. in either section. By utilizing this type of circuitry, the lack of wave distortion makes it feasible to measure the ratios of wave amplitudes. The timing device makes it practical to time wave segments from the peak of the R wave, and a single channel recorder can be utilized. Normal standards are described and deviations from normal in coronary artery disease are discussed. The low frequency, velocity measurement ballistocardiograph is easily adaptable for routine office use.
Gastrophotography in Upper Gastrointestinal Haemorrhage Without Roentgenographically Demonstrable Source of Bleeding
Authors: N. Gabrielsson
Journal: Endoscopy (1970)

A total of 120 cases bleeding from the upper gastrointestinal tract without roentgenographically demonstrable source of bleeding, have been examined with different gastrocameras. The source of bleeding was found in 66 cases and found with probability in 15 cases. Acute gastric ulcers or extensive erosions caused the bleeding in 28 cases. Peptic ulcers were found in 23 cases, of which 9 had ulcers close to the stoma in resected stomachs. The bleeding originated from gastric varices or phlebectasies in 9 cases, malignant gastric tumour in 4 cases and benign in 2 cases. Small mucosal lesions as punctuate bleedings and solitary erosions were the probable cause of bleeding in 10 cases. Varices were suspected in 2 cases and peptic ulcer in 1 case. Rejection of suture silk with small bleedings was found in 1 case and a polyp without visible active bleeding in 1 case. The group of 39 cases where no possible source of bleeding was found, included 1 case with a submucous malignant gastric tumour found on operation. The percentage of cases in which the source of bleeding was found, decreased from 88, if gastrophotography was performed within 5 days, to 24% when more than 15 days had passed since the onset of bleeding.
Second International Symposium on Stress
Authors: William R. Barclay
Journal: JAMA (1980)

MONACO, a tiny principality that mixes a certain medieval charm with 20th-century avarice, was the site of the Second International Symposium on Stress held in November 1979. Organized in honor of Hans Selye, MD, and planned for a large attendance, it attracted a disappointingly small group of approximately 200. A French air traffic controllers' strike that made travel to the conference uncertain and difficult was only one of the reasons that more people were not attracted by a program that included several Nobel Prize winners. Perhaps a program designed to appeal to everyone attracted not everyone but only a few. Perhaps a few famous experts speaking on a subject in which they had no special expertise could not compensate for a group of relatively anonymous speakers addressing subjects they apparently knew a lot about. In any event it was a small and, in my judgment, a disappointed audience. The most
Intimate Partner Violence
Authors: Janet M. Torpy
Journal: JAMA (2010)

Intimate Partner ViolenceM ore than 4 million women each year in the United States are physically harmed by their husband, boyfriend, or other intimate partner.Domestic violence, also known as intimate partner violence, not only hurts the women who are abused but also affects their overall health, their ability to earn a living, and their children.Although men can suffer from domestic violence, women are much more likely to be abused by an intimate partner than are men.The August 4, 2010, issue of JAMA is a theme issue on violence and human rights that includes several articles about intimate partner violence.This Patient Page is based on one previously published in the August 13, 2008, issue of JAMA.
Epidemiology of Invasive Childhood Pneumococcal Infections in Israel
Authors: Ron Dagan
Journal: JAMA (1992)

<h3>Objective.</h3> —To study the epidemiology of childhood pneumococcal invasive infections in Israel as a background for immunization programs. <h3>Design.</h3> —A 2-year (October 1988 through September 1990) prospective, nationwide surveillance of all invasive pediatric pneumococcal infections. <h3>Setting.</h3> —All 25 medical centers hospitalizing children in Israel, including all laboratories performing blood cultures from pediatric patients. <h3>Patients.</h3> —Infants and children aged 0 to 12 years visiting the pediatric emergency department or hospitalized in pediatric departments were included if<i>Streptococcus pneumoniae</i>was isolated from blood or cerebrospinal fluid. <h3>Results.</h3> —Four hundred sixty-nine invasive infections were diagnosed. Pneumonia, bacteremia without apparent focus, meningitis, and cellulitis were found in 39%, 37%, 17%, and 3%, respectively. The annual incidence was 42 per 100000 for children younger than 5 years of age (104 per 100000 for those &lt;12 months old). The two most common serotypes were 1 and 5, which are rare in Western Europe and North America. Eight groups comprised 82% of all invasive infections. Extrapolated to a population in which 100 000 live births occur yearly, the total annual hospitalizations for pneumococci infections was calculated to be 1928 days. The overall case-fatality rate was 2.2%, but it was 30% during the first month of life. <h3>Conclusions.</h3> —Pneumococcal invasive infections are common in children in Israel and carry considerable morbidity. (<i>JAMA</i>. 1992;268:3328-3332)
Treatment of adder bites.
Authors: A Reid
Journal: BMJ (1979)

fetal serum AFP that enters the amniotic fluid in the presence of a normal conceptus.Our results and those of Ruoslahti and colleagues emphasise that the AFP con A- binding assay on amniotic fluid has particular value in detecting the presence of communi- cating fetal abnormalities during the period when amniocenteses are usually performed, between the 14th and 18th weeks, in cases where the elevations of amniotic fluid AFP are equivocal or when gestational aging is uncertain.