Hypoparathyroidism with Hypophosphatemia
Authors: ROBERT E. LORDON
Journal: Annals of Internal Medicine (1966)

Case Studies1 May 1966Hypoparathyroidism with HypophosphatemiaA Clinical Paradox Due to Acquired Renal HyperphosphaturiaROBERT E. LORDON, JOHN J. MCPHAUL JR., DUNCAN A. MCINTOSHROBERT E. LORDONSearch for more papers by this author, JOHN J. MCPHAUL JR.Search for more papers by this author, DUNCAN A. MCINTOSHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1066 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPostoperative hypoparathyroidism resulting in hypocalcemic tetany and high serum phosphorus often requires high doses of vitamin D for control. Subsequent toxicity with hypercalcemia is a complication familiar to both surgeon and internist. The following report concerns such a patient whose treatment inadvertently led to vitamin D intoxication sustained over a 2-year period. Withdrawal of vitamin D resulted in clinical improvement, but has been followed by an unexpected hypophosphatemia. Subsequent investigation revealed an isolated renal hyperphosphaturia and, although previously unreported, it is thought to be a direct consequence of vitamin D toxicity.CASE REPORTPatient Y. F., a 33-year-old white female...References1. KYLECANARYMINTZDE LEON LHJJDHA: Inhibitory effects of induced hypercalcemia on secretion of parathyroid hormone. J. Clin. Endocr. 22: 52, 1962. CrossrefGoogle Scholar2. BUCKWALTERSOPERDAVIESMASON JARTJEE: Postoperative hypoparathyroidism. Surg. Gynec. Obstet. 101: 657, 1955. MedlineGoogle Scholar3. BARTELS EC: Hyperthyroidism—an evaluation of treatment with antithyroid drugs followed by subtotal thyroidectomy. Ann. Intern. Med. 37: 1123, 1952. LinkGoogle Scholar4. RANKEHOLINGER EJPH: Paralysis of vocal cords following thyroidectomy; a study of its association with hypothyroidism and hypoparathyroidism. JAMA 158: 543, 1955. 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New Eng. J. Med. 265: 924, 1961. CrossrefMedlineGoogle Scholar17. ALBRIGHTREIFENSTEIN FEC: Parathyroid Glands and Metabolic Bone Disease. The Williams & Wilkins Co., Baltimore, 1948. Google Scholar18. SPAULDINGYENDT WBER: Prolonged vitamin D intoxication in a patient with hypoparathyroidism. Canad. Med. Ass. J. 90: 1049, 1964. MedlineGoogle Scholar19. DONEGANMESSERORGAIN CKALES: Vitamin D intoxication due to ertron: report of two cases. Ann. Intern. Med. 30: 429, 1949. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT E. LORDON; JOHN J. MCPHAULJR.; DUNCAN A. MCINTOSHFrom the Renal Section, Department of Medicine, Wilford Hall USAF Hospital, Aerospace Medical Division (AFSC), Lackland Air Force Base, Tex.Requests for reprints should be addressed to Maj. John J. McPhaul, Jr., MC, USAF, Department of Medicine, Wilford Hall USAF Hospital, Lackland Air Force Base, Tex. 78236. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypoparathyroidismThe therapeutic approach to hypoparathyroidismHypercalcemia Associated with Neoplastic DiseaseFRANCO M. MUGGIA, M.D., HENRY O. HEINEMANN, M.D., F.A.C.P. 1 May 1966Volume 64, Issue 5Page: 1066-1070KeywordsHospital medicineHypoparathyroidismIntoxicationPatientsPhosphorusQuantitative analysisSurgeonsThyroidectomyToxicityVitamin D ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...