tbuckley/cabot-search huggingface dataset:
Dacryocystitis due to<i>Sporothrix brasiliensis</i>: a case report of a successful clinical and serological outcome with low-dose potassium iodide treatment and oculoplastic surgery
Authors: P. Marques de Macedo, D.C.N. Sztajnbok, Z.P. Camargo, A.M. Rodrigues, L.M. Lopes-Bezerra, A.R. Bernardes-Engemann, R. Orofino-Costa
Journal: British Journal of Dermatology (2014)

Journal Article Dacryocystitis due to Sporothrix brasiliensis: a case report of a successful clinical and serological outcome with low‐dose potassium iodide treatment and oculoplastic surgery Get access P. Marques de Macedo, P. Marques de Macedo Department of Dermatology Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Search for other works by this author on: Oxford Academic Google Scholar D.C.N. Sztajnbok, D.C.N. Sztajnbok Department of Pediatrics Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Search for other works by this author on: Oxford Academic Google Scholar Z.P. Camargo, Z.P. Camargo Department of Microbiology, Immunology and Parasitology Universidade Federal de São Paulo São Paulo Brazil Search for other works by this author on: Oxford Academic Google Scholar A.M. Rodrigues, A.M. Rodrigues Department of Microbiology, Immunology and Parasitology Universidade Federal de São Paulo São Paulo Brazil Search for other works by this author on: Oxford Academic Google Scholar L.M. Lopes‐Bezerra, L.M. Lopes‐Bezerra Department of Cellular Biology Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Search for other works by this author on: Oxford Academic Google Scholar A.R. Bernardes‐Engemann, A.R. Bernardes‐Engemann Department of Dermatology Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Search for other works by this author on: Oxford Academic Google Scholar R. Orofino‐Costa R. Orofino‐Costa Department of Dermatology Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Correspondence Rosane Orofino‐Costa. E‐mail: rosaneorofino@globo.com ORCID: http://orcid.org/0000-0002-1603-418X https://orcid.org/0000-0002-1603-418X Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 4, 1 April 2015, Pages 1116–1119, https://doi.org/10.1111/bjd.13378 Published: 01 April 2015
Procalcitonin is a reliable marker of severe systemic infection in neutropenic haematological patients with mucositis
Authors: Loredana Sarmati, Angela Beltrame, Luca Dori, Gaetano Maffongelli, Laura Cudillo, Gottardo De Angelis, Alessandra Picardi, Licia Ottaviani, Maria Giovanna Cefalo, Adriano Venditti, Sergio Amadori, William Arcese, Massimo Andreoni
Journal: American Journal of Hematology (2010)

et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Severe Allergic Pneumonitis from Hydrochlorothiazide
Authors: CLAUDE BEAUDRY
Journal: Annals of Internal Medicine (1973)

A 32-year-old white man with essential hypertension presented with three episodes of acute and severe pulmonary allergic pneumonitis on ingestion of one 50-mg tablet of hydrochlorothiazide. The third episode, noticed during a challenge test, was similar to the previous two episodes. To our knowledge this is the third case of severe allergic pneumonitis secondary to hydrochlorothiazide and the first in which a challenge test was done.
Frog skin opioid peptides: a case for environmental mimicry.
Authors: L H Lazarus, S D Bryant, M Attila, S Salvadori
Journal: Environmental Health Perspectives (1994)

Naturally occurring environmental substances often mimic endogenous substances found in mammals and are capable of interacting with specific proteins, such as receptors, with a high degree of fidelity and selectivity. Narcotic alkaloids and amphibian skin secretions, introduced into human society through close association with plants and animals through folk medicine and religious divination practices, were incorporated into the armamentarium of the early pharmacopoeia. These skin secretions contain a myriad of potent bioactive substances, including alkaloids, biogenic amines, peptides, enzymes, mucus, and toxins (noxious compounds notwithstanding); each class exhibits a broad range of characteristic properties. One specific group of peptides, the opioids, containing the dermorphins (dermal morphinelike substances) and the deltorphins (delta-selective opioids), display remarkable analgesic properties and include an amino acid with the rare (in a mammalian context) D-enantiomer in lieu of the normal L-isomer. Synthesis of numerous stereospecific analogues and conformational analyses of these peptides provided essential insights into the tertiary composition and microenvironment of the receptor
Anaesthesia for Air-raid Casualties
Authors: R. P. Harbord
Journal: BMJ (1942)

MEDICAL JOURtNAL nothing significant after the transfusion of fresh blood.Since all those examined had a normal liver no excretion of urobilinogen in the urine would be expected (Watson, 1938).None was found in Case 1 when 21-day-old blood was transfused. DiscussionThe fact that the level of serum bilirubin rises somewhat after the administration of stored blood but not after the administration of fresh blood suggests that at least some of the cells of stored blood are more readily broken down in the body than those of fresh blood.Since the increased pigment in circulation is bilirubin, methaemalbumin not being found in demonstrable amounts, it seems probable that the breakdown is an intracellular one.The excretion of urobilinogen was, however, unaffected to any appreciable extent by the age of the blood given or by the level of the serum bilirubin.It must therefore be concluded that, though some of the red cells of stored blood are more rapidly broken down than the red cells of fresh blood, the pigment is retained and used by the body.This is also borne out by clinical observations, appreciable rises in haemoglobin being noted in patients transfused with stored blood (Brewer et al., 1940).Mollison and Young (1940) have shown that the survival rate of cells stored in a glucose-citrate mixture is little inferior to that of fresh blood.The increased bilirubin figures recorded here are presumably due to the presence of a few effete cells in stored blood, which are immediately removed from the circulation and broken down, with liberation of bilirubin.The fact that the bilirubin level returns so rapidly to normal suggests that further undue destruction does not occur-thus sub- stantiating the figures of Mollison and Young. ConclusionsObservations on serum bilirubin and faecal urobilinogen following transfusions with fresh and stored blood are recorded.Transfused red cells appear to be broken down by the cells of the reticulo-endothelial system rather than by an intravascular mechanism.Immediately after transfusion of stored red cells there is an increase in serum bilirubin which is transitory.This increase does not occur with fresh blood, and is presumably due to the destruction of a proportion of the older cells.Since no gross difference in pigment excretion was found with the use of either fresh or stored blood it is suggested that the pigment which is rapidly liberated after transfusions with stored blood is to a large extent retained and used by the body, at least in normal -individpals.I am grateful to Dr. Hamilton Fairley for his spectroscopic exam- ination of the plasma for pigments, and to Mr. A. Hennington for his technical assistance.
The accuracy of cardiac function indices derived from ultrasonic time--position scans
Authors: D. H. EVANS, W. N. MCDICKEN, D. A. R. ROBERTSON
Journal: Cardiovascular Research (1976)

Journal Article The accuracy of cardiac function indices derived from ultrasonic time—position scans Get access D. H. EVANS, D. H. EVANS 1 1Department of Clinical Physics and Bio-Engineering, Western Regional Hospital Board, 11 West Graham Street, Glasgow. Present address and address for reprints: Department of Medical Physics, Leicester Royal Infirmary, Leicester LEI 5WW. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. N. MCDICKEN, W. N. MCDICKEN Search for other works by this author on: Oxford Academic PubMed Google Scholar D. A. R. ROBERTSON D. A. R. ROBERTSON Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 10, Issue 1, January 1976, Pages 65–73, https://doi.org/10.1093/cvr/10.1.65 Published: 01 January 1976
Blood Groups and Malignancy
Authors: Benno K. Milmore
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The paper by H. A. Fadhli and R. Dominguez, "ABO Blood Groups and Multiple Cancers" (<i>JAMA</i><b>185</b>:757 [Sept 7] 1963) calls attention to several studies in which an association between blood group A and cancer of certain sites was demonstrated. Comparison of patients with multiple cancers to several general population control groups shows that there is a significant excess of group A patients. The authors suggest "that in the type A individual a second cancer is more likely to develop." With the assumption that the selected general populations are representative of the population from which come the patients with multiple cancers, one may conclude that persons of type A<i>in the general population</i>are at greater risk of having two or more cancers than are other persons<i>in the general population</i>. It does not necessarily follow that, among patients with one cancer, those of type A
The National AIDS Information Campaign. Once upon a time in America
Authors: B. B. Dan
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improving the Scientific Misconduct Hearing Process
Authors: Debra M. Parrish
Journal: JAMA (1997)

The overturning and withdrawal of several of the Office of Research Integrity's (ORI's) findings of scientific misconduct have called its role into question. The contested findings of scientific misconduct that have been tried before the hearing body have been based on lengthy and expensive ORI investigations. How could ORI have failed to prove its findings of scientific misconduct after the commitment of substantial resources that far exceed those devoted during institutional investigations? One reason may be that the current hearing process makes it difficult or impossible for ORI, institutions, or individuals to prove scientific misconduct. The hearing process has been criticized by discouraged whistleblowers who believe that their allegations of scientific misconduct should have been upheld, and by the accused for the expensive and protracted nature of the proceedings. The following article examines problems in the scientific misconduct hearing process and suggests that the process could be improved by letting administrative law judges, patent attorneys, and a scientific majority decide these cases.
Altered S-Phase Kinase-Associated Protein-2 Levels Are a Major Mediator of Cyclic Nucleotide–Induced Inhibition of Vascular Smooth Muscle Cell Proliferation
Authors: Yih-Jer Wu, Mark Bond, Graciela B. Sala-Newby, Andrew C. Newby
Journal: Circulation Research (2006)

Cyclic nucleotides inhibit vascular smooth muscle cell (VSMC) proliferation but the underlying molecular mechanisms are incompletely understood. We studied the role of S-phase kinase-associated protein-2 (Skp2), an F-box protein of SCFSkp2 ubiquitin ligase responsible for polyubiquitylation of and subsequent proteolysis of p27Kip1, a key step leading to cell cycle progression. Skp2 mRNA and protein were upregulated in mitogen-stimulated VSMCs and after balloon injury in rat carotid arteries, where the time course and location of Skp2 expression closely paralleled that of proliferating cell nuclear antigen. Skp2 small interference RNA (siRNA) reduced Skp2 expression, increased p27Kip1 levels, and inhibited VSMC proliferation in vitro. cAMP-elevating agents prominently inhibited VSMC proliferation and Skp2 expression through inhibiting Skp2 transcription as well as decreasing Skp2 protein stability. Consistent with this, activation of protein kinase A, a downstream target of cAMP, was shown to negatively regulate focal adhesion kinase (FAK) phosphorylation and Skp2 expression. Adenovirus-mediated Skp2 expression reversed cAMP-induced p27Kip1 upregulation and rescued cAMP-related S-phase entry inhibition up to 50%. 8-bromo-cGMP also moderately reduced Skp2 and cell proliferation when VSMCs were incubated with low serum concentration. Interestingly, we showed that 8-bromo-cGMP inhibited Skp2 expression also through activation of protein kinase A, not protein kinase G, which conversely enhanced FAKY397 phosphorylation and Skp2 expression. After balloon injury of rat carotid arteries, local forskolin treatment significantly reduced FAKY397 phosphorylation, Skp2 expression, VSMC proliferation, and subsequent neointimal thickening. These data demonstrate for the first time that Skp2 is an important factor in VSMC proliferation and its inhibition by cyclic nucleotides.
Application of an artificial neural network in epiluminescence microscopy pattern analysis of pigmented skin lesions: a pilot study
Authors: M. BINDER, A. STEINER, M. SCHWARZ, S. KNOLLMAYER, K. WOLFF, H. PEHAMBERGER
Journal: British Journal of Dermatology (1994)

In vivo epiluminescence microscopy (ELM) is a non-invasive technique which improves the clinical diagnosis of naevi and malignant melanoma by providing diagnostic criteria that cannot be appreciated by the naked eye. The present study investigated whether ELM criteria pattern analysis can be employed in an objective, observer-trained, computer-aided diagnostic system, and whether artificial neural networks (ANN) can be applied to the diagnosis of pigmented skin lesions (PSL). The ELM criteria patterns of 200 PSL oil immersion images (60 common naevi, 60 dysplastic naevi, and 80 malignant melanomas) were analysed using a standardized questionnaire. One hundred randomly assigned PSL were used as a training set for an ANN, the remaining 100 PSL serving as the test set. The ANN was trained by backward propagation according to the histological diagnosis, and its performance was compared with that of human investigators. Out of the test set the human investigators correctly diagnosed 88% of PSL and the ANN 86%. In a dichotomized model comparing common, compound, and dysplastic naevi vs. malignant melanoma, i.e. benign vs. malignant PSL, the sensitivity and specificity of human diagnosis was 95 and 90%, respectively, whereas the sensitivity and specificity of the ANN diagnosis was 95 and 88%. Our data indicate that artificial neural networks can be trained to diagnose PSL at a human expert level, based on patterns provided by ELM criteria. We suggest that this technique offers a new approach to the diagnosis of PSL.
Hematopoietic stem cell transplantation in Griscelli syndrome type 2: a single-center report on 10 patients
Authors: Jana Pachlopnik Schmid, Despina Moshous, Nathalie Boddaert, Bénédicte Neven, Liliane Dal Cortivo, Marc Tardieu, Marina Cavazzana-Calvo, Stéphane Blanche, Geneviève de Saint Basile, Alain Fischer
Journal: Blood (2009)
Hydrophilic surface coatings with embedded biocidal silver nanoparticles and sodium heparin for central venous catheters
Authors: Kris N.J. Stevens, Sander Croes, Rinske S. Boersma, Ellen E. Stobberingh, Cees van der Marel, Frederik H. van der Veen, Menno L.W. Knetsch, Leo H. Koole
Journal: Biomaterials (2010)
Death after Taking Medicaments
Authors: R. H. Girdwood
Journal: BMJ (1974)

A register of reported adverse reactions, recently made available to major hospitals and medical schools gives an indication of prescribing habits under the N.H.S. in England and Wales. An analysis is made here of the chief medicaments allegedly leading to death. Such data are incomplete because of lack of knowledge of the total use of each drug in the United Kingdom and because reporting of adverse reactions is very incomplete. Nevertheless, data about various groups of drugs do draw attention to some hazards and should encourage more widespread reporting of reactions to drugs and other medicaments.
Commentary: educational initiatives deserve randomised controlled trials
Authors: D. Machin
Journal: BMJ (1997)

Diabetes and hypertension are much more prevalent among Britain's 2.5 million Asian and African-Caribbean population than among the white population and are major contributors to end stage renal failure.Asians and African-Caribbeans have threefold to fourfold higher acceptance rates on to renal replacement therapy than white people, and in some districts they comprise up to half of all patients receiving such treatment.Their greater need for renal replacement treatment is accompanied by difficulties of tissue matching in cross racial transplants and a shortage of donor organs.The aging of ethnic minority populations will increase local need for renal services significantly.Measures to control diabetes, hypertension, and secondary complications in Asian and African-Caribbean communities will contribute both to safeguarding health and to economies in spending on renal services.Education about diabetes and hypertension, modification of behavioural risk factors, early diagnosis, effective glycaemic and blood pressure control, and early referral for signs of renal impairment are essential preventive measures.Primary and community health care professionals have a critical role to play here.
The Connective Tissues
Authors: J. Ball
Journal: Annals of the Rheumatic Diseases (1967)

ExpansionScientifique Francaise, Paris.(NF 65).This second issue of "Morceaux Choisis" is devoted entirely to chronic arthritis in juveniles.The first six essays deal with juvenile rheumatoid arthritis (Still's disease).Each reviews the literature and repeats much the same historical material, and there is, not surprisingly, not much disagreement on conclusions.Notable is the contribution by J. Forestier and his colleagues from Aix-les-Bains: a 60-page essay illustrated with original statistics based on forty cases which fully examines the incidence and prognosis of the various complications.Three further papers discuss ankylosing spondy- litis with juvenile onset.That by Delbarre and Martin is based on nineteen indisputable cases, reviewed in detail and compared with those in the literature.The frequent involvement of peripheral joints is stressed, but, surprisingly, the relationship of psoriasis to these cases is not discussed.P. Doury reports that juvenile ankylosing spondylitis seems particularly common in Morocco.
Antibodies to Oxidized Low-Density Lipoproteins and Angiographically Assessed Coronary Artery Disease in White Patients
Authors: Gian Paolo Rossi, Maurizio Cesari, Renzo De Toni, Mario Zanchetta, Giuseppe Maiolino, Luigi Pedon, Chiara Ganzaroli, Pietro Maiolino, Achille C. Pessina
Journal: Circulation (2003)

Background— Low-density lipoprotein (LDL) can be oxidatively modified by reactive oxygen species, thus generating oxLDL. The latter induce formation of specific antibodies (oxLDLAb), which are detectable in patients with atherosclerosis, in which they might play a pathogenic or a protective role. Thus, we aimed to investigate the association of antibodies with oxidized LDLs (oxLDL) (oxLDLAbs) with coronary artery disease (CAD) and acute coronary syndromes. Methods and Results— In a cross-sectional study of 529 consecutive patients undergoing quantitative coronary angiography for suspected CAD, we measured the titer of IgG oxLDLAbs by ELISA. With regression analysis techniques, we also investigated the determinants of oxLDLAb titer and the association of oxLDLAbs with CAD severity. We found no significant differences of oxLDLAb titer between groups of patients without and with different CAD severity. The oxLDLAb titer was 18.6 enzyme units (EU) (11.5 to 25.7 EU/mL) (mean, 95% CI) in patients without CAD; 16.8 EU (9.6 to 24.2 EU) in patients with stenosis &lt;50%; and 19.9 EU (15 to 24.8 EU), 17.2 (13.8 to 20.6 EU), and 14.7 EU (12.1 to 17.3 EU) in those with in 1-, 2-, or 3-vessel ≥50% stenosis, respectively. Similarly, no differences of oxLDLAb titer between patients without and with acute coronary syndrome were found. The oxLDLAb titer correlated weakly with aging and with serum total, LDL, and HDL cholesterol and plasma homocysteine levels; however, only age and HDL cholesterol remained significant predictors of the oxLDLAb titer at a stepwise regression analysis. Conclusions— The results of this study, which was adequately powered from the statistical standpoint, provided no evidence for an association of IgG oxLDLAb titer with angiographically assessed CAD in whites.
Nursing and the future of primary care
Authors: S. Iliffe
Journal: BMJ (2000)

General practice pp 1038, 1043, 1048, 1053 

Set against what we already know about nurses working alongside general practitioners, 1 the four trials of nursing in primary care in this week's BMJ give us a better idea of what the future of primary care might look like.2–5 Most people seeking a rapid response to their symptoms or concerns accept practice nurses or nurse practitioners in front line roles, although a substantial minority continue to prefer a doctor's opinion after experiencing nursing attention.2

On average, nurses have longer consultations, arrange more investigations and follow up, provide more information, and give more satisfaction than general practitioners. Primary care nurses are not cheaper than general practitioners, 3 but they are as safe in managing self limiting illnesses.

Nurses undertaking triage assessments by telephone with computer decision support may reduce the number of visits to general practitioners, hospital use, and costs.5 The trials do not tell us anything about the medicalisation of …
The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects
Authors: Neil E. Alexis, Haibo Zhou, John C. Lay, Bradford Harris, Michelle L. Hernandez, Tsui-Shan Lu, Philip A. Bromberg, David Diaz-Sanchez, Robert B. Devlin, Steven R. Kleeberger, David B. Peden
Journal: Journal of Allergy and Clinical Immunology (2009)