Penicillamine-Induced Neuropathy in Rheumatoid Arthritis
Authors: K. D. POOL
Journal: Annals of Internal Medicine (1981)

Brief Reports1 October 1981Penicillamine-Induced Neuropathy in Rheumatoid ArthritisK. D. POOL, M.D., HOWARD FEIT, M.D., Ph.D., JOEL KIRKPATRICK, M.D.K. D. POOL, M.D.Search for more papers by this author, HOWARD FEIT, M.D., Ph.D.Search for more papers by this author, JOEL KIRKPATRICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-4-457 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptD-penicillamine, a known pyridoxine antagonist (1, 2), is being used with increasing frequency in the treatment of rheumatoid arthritis (3-5). We report here an adverse reaction, a profound sensory and motor neuropathy that responded to the addition of pyridoxine. Because neurologic dysfunction in patients with rheumatoid arthritis can occur as a result of several different forms of peripheral neuropathy the recognition of penicillamine-induced neuropathy may be difficult in these patients and is easily prevented with the use of pyridoxine.A 55-year-old white woman had a long history of seronegative erosive anodular rheumatoid arthritis. She had sustained involvement of all major...References1. JAFFE I. Antivitamin B6 effect on D-penicillamine. Ann NY Acad Sci. 1969;166:57-60. CrossrefMedlineGoogle Scholar2. HOLTZPALM PD. The pharmacological aspects of vitamin B6. Pharmacol Rev. 1964;16:113-78. MedlineGoogle Scholar3. Controlled trial of D-penicillamine in severe rheumatoid arthritis. Lancet. 1973;1:275-80. MedlineGoogle Scholar4. DAYGOLDINGLEEBUTTERWORTH AJPD. Penicillamine in rheumatoid disease: a long-term study. Br Med J. 1974;1:180-3. CrossrefMedlineGoogle Scholar5. SHIOKAWAHORIUCHIHONMAKAGEYAMAOKADAAZUMA YYMTTT. Clinical evaluation of D-penicillamine by multicentric double-blind comparative study in chronic rheumatoid arthritis. Arthritis Rheum. 1977;280:1464-72. CrossrefGoogle Scholar6. LENMANRITCHIE JA. Clinical Electromyography. 2nd ed. Philadelphia: J. B. Lippincott Co.; 1976: 72. Google Scholar7. CHAMBERLAINBRUCKNER MF. Rheumatoid neuropathy: clinical and electrophysiological features. Ann Rheum Dis. 1970;29:609-16. CrossrefMedlineGoogle Scholar8. WELLERBRUCKNERCHAMBERLAIN RFM. Rheumatoid neuropathy: a histological and electrophysiological study. J Neurol Neurosurg Psychiatry. 1970;33:592-604. CrossrefMedlineGoogle Scholar9. CONNDYCK DP. Angiopathic neuropathy in connective tissue diseases. In: DYCK PJ, THOMAS PK, LAMBERT EH, eds. Peripheral Neuropathy. Vol. II. Philadelphia: W. B. Saunders Co.; 1975:1149-65. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Texas Health Science Center Dallas, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress–induced depressive-like behavior in mice by regulating gut microbiota and metabolitesDrug-Induced Guillain-Barré SyndromeWilson diseasePenicillamineGLUCOCORTICOIDS AND DISEASE – MODIFYING ANTIRHEUMATIC DRUGSPenicillaminePenicillamin-induced neuropathy in rheumatoid arthritisd-penicillamine: Chemistry and clinical use in rheumatic diseaseReferencesCase report. Successful treatment of chronic cutaneous graft-versus-host-disease (GVHD) with penicillamineGUILLAIN-BARRE SYNDROME AND PEMPHIGUS FOLIACEUS ASSOCIATED WITH D-PENICILLAMINE THERAPY5 The Present Status of Chelating Agents in MedicineMetal antagonistsPyridoxine and PenicillamineMOISE D. LEVY, M.D.Periphere Neuropathie 1 October 1981Volume 95, Issue 4Page: 457-458KeywordsAdverse reactionsNeuropathyPeripheral neuropathyPyridoxineRheumatoid arthritis Issue Published: 1 October 1981 PDF downloadLoading ...