Malignant Hypertension and Red Cell Fragmentation Syndrome
Authors: JOHN P. CAPELLI
Journal: Annals of Internal Medicine (1966)

Case Studies1 January 1966Malignant Hypertension and Red Cell Fragmentation SyndromeReport of a CaseJOHN P. CAPELLI, M.D., LAURENCE G. WESSON JR., M.D., F.A.C.P., ALLAN V. ERSLEV, M.D., F.A.C.P.JOHN P. CAPELLI, M.D., LAURENCE G. WESSON JR., M.D., F.A.C.P., ALLAN V. ERSLEV, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe almost invariable association of anemia with the uremic state has long been recognized (1-3), and although it is generally agreed that the major cause of anemia in chronic renal insufficiency is depression of erythropoiesis (4, 5), the mechanism remains unknown. It has been suggested that the uremia per se inhibits erythropoiesis (6, 7), but the failure of the kidney to supply an erythropoietic hormone has been considered of greater importance. The concentration of this hormone in the serum of patients with uremia and anemia is considerably less than in other states of anemia, and although it does not appear...References1. HUNTER W: An investigation into the pathology of pernicious anaemia. Lancet 2: 608, 1888. CrossrefGoogle Scholar2. QUINKE H: Zur pathologie des blutes. Deutsch. Arch. Klin. Med. 25: 567, 1880. Google Scholar3. WIDALABRAMIBRULE FPM: Anemie grave mortelle chez une brightique azotemique. Bull. Mem. Soc. Hop. Paris 24: 1427, 1907. Google Scholar4. DESFORGESDAWSON JFJP: The anemia of renal failure. Arch. Intern. Med. 101: 326, 1958. CrossrefGoogle Scholar5. LOGELANGEMOORE JPRDCV: Charterization of the anemia associated with chronic renal insufficiency. Amer. J. Med. 24: 4, 1958. CrossrefMedlineGoogle Scholar6. CALLENLIMARZI IRLR: Blood and bone marrow studies in renal disease. Amer. J. Clin. Path. 20: 3, 1950. CrossrefMedlineGoogle Scholar7. ERSLEV AJ: The role of erythropoietin in the control of red cell production. Medicine (Balt.) 43: 661, 1964. CrossrefMedlineGoogle Scholar8. PENINGTON DG: The role of erythropoietic hormone in anaemia. Lancet 1: 301, 1961. CrossrefMedlineGoogle Scholar9. JOSKEMCALISTERPRANKERD RAJMTA: Isotope investigations of red cell production and destruction in chronic renal disease. Clin. Sci. 15: 511, 1956. MedlineGoogle Scholar10. MUIRHEADJONESSTIAMANLESCH EEFJAW: Hemolytic anemia of the dog following bilateral nephrectomy. Amer. J. Physiol. 173: 371, 1953. CrossrefMedlineGoogle Scholar11. MUIRHEADJONES EEF: Renoprival hemolysis and its prevention by renal tissue. Blood 22: 272, 1963. CrossrefMedlineGoogle Scholar12. SCHWARTZMOTTO SOSA: The diagnostic significance of "burr" red blood cells. Amer. J. Med. Sci. 218: 563, 1949. CrossrefMedlineGoogle Scholar13. BRAINDACIEHOURIHANE MCJVDO: Microangiopathic haemolytic anaemia: the possible role of vascular lesions in pathogenesis. Brit. J. Haemat. 8: 358, 1962. CrossrefMedlineGoogle Scholar14. GASSERGAUTIERSTECKSIEBENMANNOESCHLIN CEARER: Hamolytischturmishce syndrome: Bilaterale Nierenrenden-Nekrosen bei akuten erwordenen hamolytischen anamien. Schweiz. Med. Wschr. 85: 905, 1955. MedlineGoogle Scholar15. ALLISON RC: Acute haemolytic anaemia with distortion and fragmentation of erythrocytes in children. Brit. J. Haemat. 3: 1, 1957. CrossrefMedlineGoogle Scholar16. LOCKDORMANDY SPKM: Red-cell fragmentation syndrome: a condition of multiple aetiology? Lancet 1: 1020, 1961. CrossrefMedlineGoogle Scholar17. AHERNE WA: The "burr" red cell and azotaemia. J. Clin. Path. 10: 252, 1957. CrossrefMedlineGoogle Scholar18. SHUMWAYTERPLAN CNKL: Hemolytic anemia, thrombocytopenia and renal disease. Pediat. Clin. N. Amer. 11: 577, 1964. CrossrefMedlineGoogle Scholar19. VERELTURNBULLTUDHOPEROSS DAGRJH: Anaemia in Bright's disease. Quart. J. Med. 28: 491, 1959. MedlineGoogle Scholar20. Case Record. A case of malignant hypertension with haemolytic anaemia. Brit. Med. J. 2: 617, 1964. CrossrefMedlineGoogle Scholar21. BRAINBECK MCEA: Relationship of intravascular coagulation and intravascular hemolysis. Presented at the fifty-seventh annual meeting of the American Society for Clinical Investigation, Atlantic City, N. J., May 2 and 3, 1965. Google Scholar22. STOHLMANSARNOFFCASENESS FSJRBAT: Hemolytic syndrome following insertion of lucite ball valve prosthesis into cardiovascular system. Circulation 13: 586, 1956. CrossrefMedlineGoogle Scholar23. NEILLFORMARSIGLERBAHNSON CAENATHT: Hemolytic anemia following surgical repair of endocardial cushion defects. Presented at the thirty-first annual meeting of Society for Pediatric Research, Atlantic City, N. J., May 4 and 5, 1961. Google Scholar24. SAYEDDACIEHANDLEYLEWISCLELAND HMJVDASMNP: Haemolytic anaemia of mechanical origin after open heart surgery. Thorax 16: 356, 1961. CrossrefMedlineGoogle Scholar25. VERDONFORRESTERCROSBY TARHWH: Hemolytic anemia after open-heart repair of ostium-primum defects. New Eng. J. Med. 269: 444, 1963. CrossrefMedlineGoogle Scholar26. Case Records of the Massachusetts General Hospital (Case 52-1964). New Eng. J. Med. 271: 898, 1964. CrossrefMedlineGoogle Scholar27. PIROFSLAYSUTHERLANDSTARRGRISWOLD BDWAHE: Hemolytic anemia complicating aortic-valve surgery: autoimmune syndrome. New Eng. J. Med. 272: 235, 1965. CrossrefMedlineGoogle Scholar28. CHAPLINMOLLISON HPL: Red cell lifespan in nephritis and hepatic cirrhosis. Clin. Sci. 12: 351, 1953. MedlineGoogle Scholar29. RATHER LJ: Renal athrocytosis and intracellular digestion of intraperitoneally injected hemoglobin in rats. J. Exp. Med. 87: 163, 1948. CrossrefMedlineGoogle Scholar30. LEONARDIRUOL PA: Renal hemosiderosis in the hemolytic anemias: diagnosis by means of needle biopsy. Blood 16: 1029, 1960. CrossrefMedlineGoogle Scholar31. BOTHWELLFINCH THCA: Iron Metabolism, 1st ed. Little, Brown and Co., Boston, 1962, p. 413. Google Scholar32. REUBIGROSSWEILERGURTLERHUBER FCNRA: The renal blood flow in acute renal failure, in Acute Renal Failure, edited by SHALDON, S., COOK, G. C. F. A. Davis Co., Philadelphia, 1964, p. 25. Google Scholar33. MUNCK O: Renal circulation in acute renal failure measured with radioactive krypton85 and xenon133. Ibid., p. 15. Google Scholar34. MUIRHEADJONES EEF: Lowered glucose utilization, phosphate uptake, and reduced glutathione content of erythrocytes following bilateral nephrectomy. J. Lab. Clin. Med. 51: 49, 1958. MedlineGoogle Scholar35. BELL RE: The origin of the "burr" erythrocytes. Brit. J. Haemat. 9: 552, 1963. CrossrefMedlineGoogle Scholar36. NATHANSCHUPAKSTOHLMANMERRILL DGEFJP: Erythropoiesis in anephric man. J. Clin. Invest. 43: 2158, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN P. CAPELLI, M.D.; LAURENCE G. WESSONJR., M.D., F.A.C.P.; ALLAN V. ERSLEV, M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaFrom the Department of Medicine and the Cardeza Foundation, Jefferson Medical College Hospital, Philadelphia, Pa.Requests for reprints should be addressed to John P. Capelli, M.D., Department of Medicine, Jefferson Medical College Hospital, 1025 Walnut St., Philadelphia, Pa. 19107. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlterations in Blood ComponentsCase Report: Red Cell Fragmentation Produced by Renal Artery StenosisRecent Developments in the Anemia of Chronic Renal FailureHämatologische Aspekte arterieller HypertonieHematologic Aspects of Arterial HypertensionRed Cell Fragmentation in the Dog: An Editorial ReviewHypertensive emergenciesMicroangiopathic Hemolytic Anemia Associated with Radiation-Induced HemangiosarcomasHämatologische Aspekte arterieller HypertonieDie Klinik des h�molytisch-ur�mischen SyndromsHematologic Complications of Chronic Renal FailureCase Number 12 Hypertension with NephrosclerosisThe Significance of Microangiopathic Haemolytic Anaemia in Accelerated HypertensionOliguric acute renal failure in malignant hypertensionMICROANGIOPATHIC HÆMOLYTIC ANÆMIA AND THE PATHOGENESIS OF MALIGNANT HYPERTENSIONMicroangiopathic Hemolytic Anemia in Carcinoma of the Stomach 1 January 1966Volume 64, Issue 1Page: 128-136KeywordsAnemiaAttentionErythropoiesisHormonesHospital medicineHypertensionRenal failure ePublished: 1 December 2008 Issue Published: 1 January 1966 PDF downloadLoading ...