tbuckley/cabot-search huggingface dataset:
Disseminated mycobacterium <i>avium</i>‐intracellulare infection in a patient with myelodysplastic syndrome (refractory anemia)
Authors: Hiroko Tsukada, Takaaki Chou, Yasuo Ishizuka, Osamu Ogawa, Takako Saeki, Satoshi Ito, Masaya Wakabayashi, Naoki Hayashi, Masaaki Arakawa
Journal: American Journal of Hematology (1994)

Abstract A 31‐year‐old woman presented with fever and arthralgla. Despite treatment with antimicrobials and cortlcosteroids, her symptoms persisted. A diagnosis of myelodysplastic syndrome (MDS)‐refractory anemia (RA) was made by pancytopenia, dysplasia, and trisomy 8. Cultures of bone marrow, blood, and gastric juice showed Mycobacterium aviumintraceliuiare (MAI). She was treated with antimycobacterial drugs and recombinant human G‐CSF/M‐CSF and showed an initial response, but spike fever recurred and pancytopenia progressed. Hepatospienomegaly and marked retroperitoneal lymphade‐nopathy were revealed, indicating further dissemination of MAI. Treatment with recombinant human GM‐CSF and very‐low‐dose cytosine arabinoside, was started but was not effective. This case showed significant reduction in peripheral blood 1‐lymphocytes, especially the CD4 + population, and low immunoglobulin levels. immunodeficiency state associated with long‐term steroid therapy and MDS seemed to contribute to the development of the disseminated infection with MAI. © 1994 Wiley‐Liss, Inc.
THE STATUS OF THE NEGATIVE WASSERMANN REACTION
Authors: ROBERT A. KILDUFFE
Journal: JAMA (1922)

Probably because of the protean character of its manifestations, there is no disease presenting more inherent difficulties in its management than syphilis, and there are few in which more terrible and well-nigh inexcusable errors have been committed. This may be maintained as to both diagnosis and treatment, and it is to a realization of these facts, reenforced by the enormous increase in our general knowledge of the disease that, perhaps, we owe the evolution of the syphilologist. In spite of the fact that the condition is one that requires the most expert and skilled management if its complete control is to be attained, for reasons that are apparent a large proportion of cases will always be cared for by the man in general practice. Much emphasis has been laid on the vital importance of an early diagnosis and the prompt initiation of treatment; much has been written concerning the dangers
Health of the world's adolescents: a synthesis of internationally comparable data
Authors: George C Patton, Carolyn Coffey, Claudia Cappa, Dorothy Currie, Leanne Riley, Fiona Gore, Louisa Degenhardt, Dominic Richardson, Nan Astone, Adesola O Sangowawa, Ali Mokdad, Jane Ferguson
Journal: The Lancet (2012)
Impairment of Rosette-Forming T Lymphocytes in Chronic Marihuana Smokers
Authors: Sudhir Gupta, Michael H. Grieco, Paul Cushman
Journal: New England Journal of Medicine (1974)

Rosettes formed by circulating T and B lymphocytes obtained from 23 healthy, chronic marihuana smokers were compared with those in 23 normal control subjects who denied marihuana use. The mean percentage of T cells forming rosettes was lower in the marihuana smokers (p < 0.005). Nine of 23, or 39 per cent, had T-cell rosette formation lower than 2 standard deviations below the mean for control subjects. The percentages of B-cell rosettes were similar in both marihuana smokers and the controls. This study suggests suppression of a T-lymphocyte subpopulation in chronic marihuana smokers. (N Engl J Med 291:874–877, 1974)
Double-Orifice Tricuspid Annulus
Authors: José-Luis Moya Mur, Derly-Carlos Becker Filho, Daniel Rodríguez Muñoz, Marcelo Haertel Miglioranza, Antonio Epeldegui Torres, Covadonga Fernández Golfín, José-Luis Zamorano Gómez
Journal: Journal of the American College of Cardiology (2013)
Dextrocardia with Situs Inversus and Atrial Septal Defect Complicated by Acute Rheumatic Fever
Authors: PAUL B. JENNINGS
Journal: Annals of Internal Medicine (1961)

Case Reports1 July 1961Dextrocardia with Situs Inversus and Atrial Septal Defect Complicated by Acute Rheumatic FeverPAUL B. JENNINGS, M.D., F.A.C.P., ESTELLE E. KLEIBER, M.D., F.A.C.P., RALPH LEV, M.D., M.S.PAUL B. JENNINGS, M.D., F.A.C.P.Search for more papers by this author, ESTELLE E. KLEIBER, M.D., F.A.C.P.Search for more papers by this author, RALPH LEV, M.D., M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-1-134 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis case of a 14-year-old girl with congenital heart disease is reported because of the following interesting and unusual features:1. Dextrocardia and situs inversus with associated congenital cardiac anomaly (atrial septal defect), without cyanosis at the present time.2. Acute rheumatic fever superimposed upon the above, presenting as an acute surgical abdomen and resulting in a left-sided appendectomy.3. An electrocardiogram showing an upright P wave in Lead 1 in the presence of a left-sided superior vena cava.4. The stability of this patient's cardiac status over a period of ten years' observation and in the presence of cardiac...References1. CAMPBELLREYNOLDS MG: The significance of the direction of the P wave in dextrocardia and isolated laevocardia. Brit. Heart J. 14: 481, 1952. CrossrefMedlineGoogle Scholar2. TAUSSIG HB: Congenital Malformations of the Heart, The Commonwealth Fund, New York, 1947, p. 372. Google Scholar3. FRIEDBERG CK: Diseases of the Heart, 2nd Ed., W. B. Saunders Company, Philadelphia, 1956, p. 835. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Brunswick, New JerseyReceived for publication March 28, 1960.From the Department of Medicine, the Cardiopulmonary Laboratory, and the Surgical Research and Medical Investigation Laboratory, St. Peter's Hospital, New Brunswick, N. J.Requests for reprints should be addressed to Estelle E. Kleiber, M.D., 138 Livingstone Ave., New Brunswick, N. J. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1961Volume 55, Issue 1Page: 134-139KeywordsAppendectomyAtrial septal defectCongenital heart diseaseElectrocardiographyHospital medicinePneumoniaResearch laboratoriesRheumatic fever Issue Published: 1 July 1961 PDF DownloadLoading ...
Stephen Anthony Cullen
Authors: T. Batchelor, J. L Christie
Journal: BMJ (2010)

Air Commodore Stephen Anthony Cullen (“Tony”) was an aviation pathologist of international repute.

Tony, himself the son of a doctor, was born in Liverpool in 1939 and qualified in medicine from Liverpool Medical School in 1962.

He was commissioned into the Royal Air Force Medical Branch in 1964, and after initial general training was posted to the RAF Institute of Pathology and Tropical Medicine (IPTM), Halton, to train in pathology. In 1967 he was attached to the Royal Australian Air Force Hospital, Butterworth, Malaysia, then a main transit point for Australian military personnel en route to Vietnam, and for casualties returning to Australia. While at Butterworth, Tony, typically, managed to remain friends with everyone, while achieving a major upgrade in the pathology service.

However, soon after returning to IPTM, he began his life’s work as a forensic pathologist specialising in aircraft accident investigation. In this he followed Group Captain (later Professor) Ken Mason, Group Captain Peter Stevens, and Group Captain Tony Balfour. Over a working lifetime Tony gained a breadth and depth of experience which was unique.

In fatal aircraft accidents, the pathologist deals usually with fragmented and commingled human remains. Yet he hopes to identify the deceased (especially the pilot and other aircrew) and, with the other on site investigators to reconstruct the accident, on the basis of the patterns of injuries found in the passengers and crew. (Occasionally, it …
Dangers of Hypnosis
Authors: Louis J. West
Journal: JAMA (1965)

Hypnosis as a technique in medical practice poses certain dangers to the patient, to the physician, to medicine as a discipline, and to hypnotism itself as a reputable body of information and methodology. At the same time hypnosis offers definite advantages as an adjunct to other methods in medicine and psychiatry; these advantages should be preserved. The dangers can be minimized by improved and expanded programs of research on hypnosis, more education concerning it both at the undergraduate and postgraduate levels in medical schools, and greater clarification of standards for its clinical employment. Over-commitment to hypnotism should be avoided by the clinician, who should at the same time be prepared to use this valuable maneuver when indicated.
Remarks of the President
Authors: C. L. Hudson
Journal: JAMA (1967)

As our ages advance, years have a faculty for passing very quickly, but none in my experience so rapidly as the year I am ending this week. It has been a busy year. In making many, many appearances I have traveled to a new location on an average of every five days and have made a scheduled speech about every two days. Also I have had innumerable press conferences, made frequent radio and television appearances and in many instances impromptu responses to dinner-meeting chairmen to "say a few words." Some of the most rewarding meetings have been informal discussions with members. It has been a wonderful year but not altogether an easy one. It has provided great satisfactions, most of which have come from serving in the highest office of the American Medical Association, and many more emanating from the deference and respect shown that office. I thanked you a
Comment on: American Diabetes Association. Standards of Medical Care in Diabetes—2011. Diabetes Care 2011;34(Suppl. 1):S11–S61
Authors: Vittorio Basevi, Simona Di Mario, Cristina Morciano, Francesco Nonino, Nicola Magrini
Journal: Diabetes Care (2011)

How to screen and treat gestational diabetes mellitus (GDM) has always been controversial for clinicians and decision makers. The problem is complex, and the evidence is limited. The new standards set by the American Diabetes Association (ADA) in 2011 (1) recommend 1 ) universal screening at 24–28 weeks of gestation (2010 ADA standards recommended selective screening based on risk factors) and 2 ) an oral glucose tolerance test with a diagnostic fasting plasma glucose of ≥92 mg/dL (4.5 mmol/L) (much lower than the World Health Organization [WHO] criteria of ≥126 mg/dL [7.0 mmol/L] commonly used in clinical practice in Europe). Furthermore, diabetes is diagnosed when only one abnormal value is detected (whereas in the 2010 standards two …
Pharmacodynamics of Human Insulin (recombinant DNA)—Regular, NPH, and Mixtures—Obtained by the Gerritzen Method in Healthy Volunteers
Authors: Kurt Weinges, Manfred Ehrhardt, Gerfried Nell, Franz Enzmann
Journal: Diabetes Care (1982)

The study was concerned with the comparison of the action profile of regular and NPH preparations of human insulin (recombinant DNA) and of PPI (pork purified insulin). In addition, the action profiles of some mixtures (10:90, 15:85, 20:80, 25:75, 30:70) of regular and NPH human insulin were evaluated. The comparisons were based on the Gerritzen test. There was no statistically significant difference in the time-course of the blood glucose levels after administration of NPH human insulin and NPH PPI. A tendency was noted, however, that NPH human insulin has a faster onset of action and that the serum glucose minimum for NPH human insulin lasts longer. The serum glucose curves after the application of regular and NPH human insulin initially lie closer together than after the respective PPI preparations. In the later phase, regular human insulin interferes less with the NPH curves. This means that combinations of regular and NPH human insulin may have a clinically useful action profile. No skin reaction or other adverse reaction was detected after application of human insulin and no antibodies against human insulin and Escherichia coli protein were found.
Effect of bypass surgery on survival in patients in low- and high-risk subgroups delineated by the use of simple clinical variables.
Authors: K Detre, P Peduzzi, M Murphy, H Hultgren, J Thomsen, A Oberman, T Takaro
Journal: Circulation (1981)

A multivariate risk function was developed on data from all 508 medical patients in the Veterans Administration (VA) randomized study of coronary bypass surgery. The variables, in order of importance, were ST-segment depression on resting ECG, history of myocardial infarction, history of hypertension and New York Heart Association functional classification III or IV. These noninvasive variables have been reported to be risk factors in natural-history studies of coronary heart disease (CHD). Applying the risk function to medical and surgical patients of the 1972-1974 cohort yielded a 5-year probability of dying for each patient. Investigation of treatment effects in approximate terciles obtained by collapsing the probability distribution into low-, middle- and high-risk groups showed that surgery was beneficial for patients in the high-risk tercile even after removal of patients with left main coronary artery disease (17% surgical vs 34% medical mortality at 5 years; p less than 0.01). This finding was accentuated when patients in the 10 hospitals with the lowest operative mortality (3.3%) were compared. Mortality results in the low-risk tercile favored medical treatment (medical vs surgical mortality 7% vs 17%; p less than 0.05). The risk function predicted mortality well not only for te VA medical group, but also for an independent symptomatic CHD population from the University of Alabama arteriography registry. This report further delineates the advantages and limitations of coronary bypass surgery in CHD patients with chronic stable angina.
Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4
Authors: Luciano F. Drager, Qiaoling Yao, Karen L. Hernandez, Mi-Kyung Shin, Shannon Bevans-Fonti, Jason Gay, Thomas E. Sussan, Jonathan C. Jun, Allen C. Myers, Gunilla Olivecrona, Alan R. Schwartz, Nils Halberg, Philipp E. Scherer, Gregg L. Semenza, David R. Powell, Vsevolod Y. Polotsky
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Rationale: Obstructive sleep apnea is a risk factor for dyslipidemia and atherosclerosis, which have been attributed to chronic intermittent hypoxia (CIH). Intermittent hypoxia inhibits a key enzyme of lipoprotein clearance, lipoprotein lipase, and up-regulates a lipoprotein lipase inhibitor, angiopoietin-like 4 (Angptl4), in adipose tissue. The effects and mechanisms of Angptl4 up-regulation in sleep apnea are unknown.Objectives: To examine whether CIH induces dyslipidemia and atherosclerosis by increasing adipose Angptl4 via hypoxia-inducible factor-1 (HIF-1).Methods: ApoE−/− mice were exposed to intermittent hypoxia or air for 4 weeks while being treated with Angptl4-neutralizing antibody or vehicle.Measurements and Main Results: In vehicle-treated mice, hypoxia increased adipose Angptl4 levels, inhibited adipose lipoprotein lipase, increased fasting levels of plasma triglycerides and very low density lipoprotein cholesterol, and increased the size of atherosclerotic plaques. The effects of CIH were abolished by the antibody. Hypoxia-induced increases in plasma fasting triglycerides and adipose Angptl4 were not observed in mice with germline heterozygosity for a HIF-1α knockout allele. Transgenic overexpression of HIF-1α in adipose tissue led to dyslipidemia and increased levels of adipose Angptl4. In cultured adipocytes, constitutive expression of HIF-1α increased Angptl4 levels, which was abolished by siRNA. Finally, in obese patients undergoing bariatric surgery, the severity of nocturnal hypoxemia predicted Angptl4 levels in subcutaneous adipose tissue.Conclusions: HIF-1–mediated increase in adipose Angptl4 and the ensuing lipoprotein lipase inactivation may contribute to atherosclerosis in patients with sleep apnea.
P06.03 * CASE REPORT OF A METASTASIS OF SQUAMOUS CELL LUNG CARCINOMA INTO AN INTRACRANIAL MENINGIOMA
Authors: M. Hartenau, W. Grisold, K. Lindner, J. Preiser, B. Horvat-Mechtler, B. Surboeck
Journal: Neuro-Oncology (2014)

INTRODUCTION: Rare cases of tumor-to-meningioma metastases have yet been reported before. Cancer metastasis into a meningioma is a rare and often incidential finding. The most commonly reported malignancies are breast and lung cancer. Meningiomas are the most common intracranial lesion to host metastatic tissue and meningiomas seem to provide a favorable environment for metastatic seeding. Several factors responsible for tumor metastasis into meningioma have been proposed :meningiomas are highly vascular and also grow slowly. In addition their high collagen and lipid content seems to be supportive to the seeding and growing of malignant cells. Also, meningeomas express binding proteins which may also play a role in metastatic seeding. CASE REPORT: A 73-year-old woman was admitted because of progression with a 3-week history of her former of left sided arm weakness. She had undergone a right upper lobectomy for poorly differentiated sqamous cell carcinoma of the lung 3 months ago. An MRI scan of the brain revealed a lesion the size of 3.5 cm on the right parietal side. It was adhering to the dura mater, which suggested an extraaxial origin of the tumor and meningeoma was suggested. The lesion showed significant contrast agent uptake and was surrounded by peritumoral edema. A surgical removal of the lesion was performed. Histologic analysis showed a secretory meningioma (WHO grade I) highly infiltrated with metastatic cancer cells of a poor-differentiated squamous cell carcinoma. The focus within the meningeoma stained positive for p16, CK 5/6, p63/HMW-CK, CK AE 1/3 and negative for TTF-1, Ki-67. The patient was treated with postoperative cerebral radiation theraphy. A CT staging of the chest and abdomen was performed and revealed new blastomatoid lesions of the lung, liver and the left adrenal gland. The general condition of the patient deteriorated fast in the following weeks and she died two months after surgery as a result of the reactivation of the malignant squamous cell lung carcinoma. DISCUSSION: The phenomenon of tumor to tumor metastasis is defined by two criteria: The metastatic focus must be encased by a rim of histologically distinct tumor tissue and a proven primary carcinoma that is compatible with the metastasis. In this patient, an intracranial meningeoma was the target for the seeding of a malignant systemic cancer. Given the comparatively large number of patients with meningeoma and even larger number of persons with cancer this coincidence could be seen higher than reported. The practical issue is to identify future factors to identify patients with cancer metastasis into meningioma to improve therapeutic strategies.
Vital Involvement in Old Age
Authors: Julia Bess Frank
Journal: JAMA (1987)

Most longitudinal studies of adult development end in middle or late middle age. The logistical difficulties of following up people for prolonged periods may only partially explain this gap in our knowledge. Another explanation is that most developmental researchers have not yet themselves reached old age. Their personal inexperience with this stage of life is a significant handicap in their ability to understand the questions it raises. Erik Erikson, the 95-year-old grandfather of the empirical study of normal development, is in a unique position to fill this gap in psychological research. Along with his wife and a younger colleague, he had followed up a group first encountered as parents of children studied developmentally since the 1930s. In<i>Vital Involvement in Old Age</i>, the three investigators present the results of their interviews with these 29 men and women, aged 75 to 95 years. Unlike the subjects of cross-sectional studies of the
Medical Men Who Have Attained Fame in Other Fields of Endeavor
Authors: ERNEST WEINFIELD
Journal: Annals of Internal Medicine (1932)

Article1 September 1932Medical Men Who Have Attained Fame in Other Fields of EndeavorIII. Medical Humorists. IV. Medical Men as Inventors. V. Medical Men as ExplorersERNEST WEINFIELD, B.S., M.D.ERNEST WEINFIELD, B.S., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-3-444 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIII. MEDICAL HUMORISTSSaavedra Miguel de Cervantes (1547-1616) the greatest of Spanish writers, bent upon the alleviation of all the ills of mankind, was a doctor in very truth. He early commenced writing verses, and his pastoral, "Filena", attracted the attention of Cardinal Acquaviva whom he accompanied to Italy as page. In 1570 when serving in the war against the Turks and African corsairs, he lost the use of his left hand. In 1583 he retired from service and recommenced his literary work, publishing in 1584 his pastoral "Galatea". He lived by writing for the stage, to which he contributed... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERNEST WEINFIELD, B.S., M.D.Affiliations: New Orleans, La.Received for publication, November 28, 1931.Note by Editor: Previous items in this series were I. Medical Men as Musicians, ANN. INT. MED., 1930, iii, 1047-1054; and II. Medical Poets, ANN. INT. MED., 1930, iii, 1279-1287. Dr. Weinfield had planned a group of articles covering the outstanding contributions of medical men to all the non-medical arts and sciences. He left much material in well-organized form at the time of his death. The present sections are selected from that material, made available through the courtesy of Mrs. Weinfield. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1932Volume 6, Issue 3Page: 444-448 ePublished: 1 December 2008 Issue Published: 1 September 1932 PDF downloadLoading ...