Acute Erythroid Aplasia (Erythroblastopenia) and Vascular Purpura in an Otherwise Hematologically Normal Child
Authors: SELIG M. GINSBURG
Journal: Annals of Internal Medicine (1961)

Case Reports1 August 1961Acute Erythroid Aplasia (Erythroblastopenia) and Vascular Purpura in an Otherwise Hematologically Normal ChildSELIG M. GINSBURG, M.D.SELIG M. GINSBURG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-2-317 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Owren's description in 1948 of aplastic crisis in congenital hemolytic jaundice (1), crises have been demonstrated to occur in hemolytic disorders, including other cases of congenital hemolytic jaundice (2-6), sickle cell anemia (7-9), and acquired hemolytic anemia (3, 9, 10). However, it is not generally recognized that aplastic crisis may occur in an otherwise hematologically normal individual. Because of the implications of aplastic crisis in such an individual, and the infrequency with which this condition is reported, the following case may prove to be both interesting and informative.CASE REPORTA ten-year-old Puerto Rican girl was admitted to The...References1. OWREN PA: Congenital hemolytic jaundice: pathogenesis of "hemolytic crisis." Blood 3: 321, 1948. CrossrefGoogle Scholar2. GASSER C: Akute Erythroblastopenie: Zehn Fälle aplastischer Erythroblastenkrisen mit Riesenproerythroblasten bei allergisch-toxischen Zustandsbildern. Helv. Paediat. Acta 4: 107, 1949. MedlineGoogle Scholar3. GASSERADANK CW: Akute Erythroblastopenie mit Auftreten abnormer Riesenproerythroblasten im Kochenmark. Helv. Paediat. Acta 5: 37, 1950. Google Scholar4. DAMESHEKBLOOM WML: The events in the hemolytic crisis of hereditary spherocytosis, with particular reference to the reticulocytopenia, pancytopenia, and an abnormal splenic mechanism. Blood 3: 1381, 1948. CrossrefMedlineGoogle Scholar5. MASONMEYNELLTABBUSH FGMJH: Familial crisis in acholuric jaundice. Brit. Med. J. 2: 760, 1950. CrossrefMedlineGoogle Scholar6. BATTLE JD: Hereditary spherocytosis (congenital hemolytic jaundice): pathogenesis of the "hemolytic" crisis. Amer. J. Med. Sci. 224: 82, 1952. CrossrefMedlineGoogle Scholar7. SINGERMOTULSKYWILE KAGSA: Aplastic crisis in sickle cell anemia: a study of its mechanism and its relationship to other types of hemolytic crisis. J. Lab. Clin. Med. 35: 721, 1950. MedlineGoogle Scholar8. CHERNOFFJOSEPHSON AIAM: Acute erythroblastopenia in sickle cell anemia and infectious mononucleosis. Amer. J. Dis. Child. 82: 310, 1951. Google Scholar9. MIESCHBAXTERLEVIN DCMRWC: Acute erythroblastopenia: pathogenesis. Arch. Intern. Med. 99: 461, 1957. CrossrefGoogle Scholar10. DAVISKENNEDYBAIKIEBROWN LJACAGA: Haemolytic anemias of various types treated with ACTH and cortisone: report of ten cases, including one of acquired type in which erythropoietic arrest occurred during crisis. Glasgow Med. J. 33: 263, 1952. MedlineGoogle Scholar11. MAGGIONI G: Erythroblastopenia acuta transitoria in un lattante. Haematologica 37: 415, 1953. MedlineGoogle Scholar12. WASSERMANSTATSSCHWARTZFUDENBERG LRDLH: Symptomatic and hemopathic hemolytic anemia. Amer. J. Med. 18: 961, 1955. CrossrefMedlineGoogle Scholar13. KOBL H: Subsepsis allergica mit akuter Erythroblastopenie und abnormer Riesenproerythroblastenbildung. Z. Kinderheilk. 75: 525, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.Received for publication May 27, 1960.From the Department of Hematology, The Mount Sinai Hospital, New York, N. Y.Aided by the Albert A. List, Frederick Machlin, and Anna Ruth Lowenberg Research Funds.Requests for reprints should be addressed to Selig M. Ginsburg, M.D., 2 E. 84th St., New York 28, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTRANSIENT HYPOPLASTIC ANEMIA OF CHILDHOODCongenital erythropoietic porphyriaTeilungsstörungen der Erythropoese: Perniciosa-Syndrom und Erythroblastopenie-Syndrom 1 August 1961Volume 55, Issue 2Page: 317-321KeywordsAplastic anemiaAsthmaEosinophiliaHematology and oncologyHemoglobinHemolytic anemiaHemolytic jaundiceHispanic peoplePharyngitisResearch funding Issue Published: 1 August 1961 PDF DownloadLoading ...