tbuckley/cabot-search huggingface dataset:
Renal function of conscious spontaneously hypertensive rats.
Authors: W H Beierwaltes, W J Arendshorst
Journal: Circulation Research (1978)

Renal clearance studies were performed in conscious 13-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) before and during volume expansion by intravenous infusion of isotonic saline. Mean arterial pressure and filtration fraction were greater in SHR, whereas fractional and absolute excretion of sodium and water, glomerular filtration rate, and renal plasma flow in SHR and WKY were not statistically different. This was the case during hydropenia and volume expansion. We did not observe as exaggerated natriuresis after intravenous loading when unanesthetized SHR were compared with the response of WKY. These observations suggest that the kidneys of genetically hypertensive rats of the Okamoto-Aoki strain have adapted to an elevated renal perfusion pressure or that hypertension is required to normalize renal function so that excretion is appropriately matched with intake.
TCT-430 Myocardial Bridging Increases Diffuse and Focal Chronic Stent Recoil Following Drug-Eluting Stent Implantation
Authors: Ryotaro Yamada, Katsuhisa Waseda, Kenji Sakamoto, Hideki Kitahara, Ching-Chang Huang, Paul Yock, Peter Fitzgerald, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2012)
CROSSING OVER BETWEEN GENES IN THE IMMUNOGLOBULIN HEAVY CHAIN LINKAGE GROUP OF THE MOUSE
Authors: Rose Lieberman, Michael Potter
Journal: The Journal of Experimental Medicine (1969)

Immunoglobulin heavy chain genes were found in wild mice (Mus musculus) that could best be explained as recombinants of immunoglobulin genotypes. In wild mice from Kitty Hawk, N. C., two new heavy chain linkage groups, G(3,5,7,8)H(9,11)F(f)A(-) and G(3,5,8)H(9,11)F(f)A(-), were found, each of which genetically controls both the 3 and 5 distinct immunoglobulin determinants. In inbred strains the 3 and 5 determinants are found independently. The new heavy chain allotype G(3,5,7,8)H(9,11)F(f)A(-) probably arose from a homologous (intragenic) cross-over between G(3,8)H(9,11)F(f)A(-) and G(5,7,8)H(9,11)F(f)A(14) heavy chain linkage groups. It was suggested that genes controlling G(3,8)G(5,7,8), G(3,5,8), and G(3,5,7,8) are alleles. Another homozygous wild mouse (Kyushu, Japan) showed a new heavy chain allotype, (2)G(1,6,7,8)H(9,16)F(s)A(15). The 2 and G(1,6,7,8) determinants are also separated in inbred strains. The 2 determinant in inbred mice is not on the gammaF, gammaH, or gammaA heavy chain and is probably on a gammaG or gammaG-like immunoglobulin heavy chain. Papain digestion of serum from the Kyushu mouse showed two electrophoretically different Fc fragments, one carrying the G(1,6,7,8) and the other the 2 determinant. The new heavy chain allotype, (2)G(1,6,7,8)H(9,16)F(s)A(15), of the Kyushu wild mouse probably arose from a nonhomologous (unequal) cross over between (2)G(-)H(9,16)F(s)A(15) and G(1,6,7,8)H(9,11)F(f)A(12,13,14) heavy chain linkage groups. The linkage group of the Kyushu wild mouse has at least five heavy chain genes, while that of the inbred mice has four.
Glucocorticoids downregulate COX-1 positive cells in nasal polyps
Authors: F.A. Ebbens, M. Maldonado, E.J.J. Groot de, I. Alobid, C.M. Drunen van, C. Picado, W.J. Fokkens, J. Mullol
Journal: Journal of Allergy and Clinical Immunology (2005)
Apes, humans, and M. C. Escher: Uniqueness and continuity in the evolution of language
Authors: Barbara J. King
Journal: Behavioral and Brain Sciences (2006)

Ontogeny, specifically the role of language in the human family now and in prehistory, is central to Locke &amp; Bogin's (L&amp;B's) thesis in a compelling way. The unique life-history stages of childhood and adolescence, however, must be interpreted not only against an exceptionally “high quality” human infancy but also in light of the evolution of co-constructed, emotionally based communication in ape, hominid, and human infancy.
Normalization of portal pressure (PP) following end-to-side portacaval shunt (PCS) worsens systemic hemodynamic abnormalities in cirrhosis
Authors: A. Luca, I. Cirera, O. Pereira, F. Feu, JC. García-Pagán, M. Fernández, J. Bosch, J. Rodés
Journal: Journal of Hepatology (1991)
Effect of ethyloestrenol on fibrinolysis in the vessel wall.
Authors: U Hedner, I M Nilsson, S Isacson
Journal: BMJ (1976)

Forty-nine patients with decreased fibrinolytic activity in the vessel walls or a decreased release mechanism, or both, were treated with ethyloestrenol for three to 17 months. Forty-five of the patients had had recurrent, phlebographically verified, deep venous thrombosis (DVT) and four had arterial thrombosis. Ethyloestrenol 8 mg/day was given to 31 patients and 4 mg/day was given to 12. The remaining six patients had been treated with a combination of phenformin and ethloestrenol. The phenformin was withdrawn but they were kept on ethyloestrenol 8 mg/day. Another 15 patients with a normal fibrinolytic system--four with recurrent DVT and 11 with severe arteriosclerosis--were given ethyloestrenol 8 mg/day. The spontaneous fibrinolytic activity, local fibrinolytic activity during standardised venous occlusion of the arms, and fibrinolytic activity of the vessel walls increased significantly after treatment with ethyloestrenol 8 mg/day for three months. No further increase occurred after three months, and ethyloestrenol 4 mg/day had no effect. No values rose significantly in the patients with a normal fibrinolytic system. One patient suffered a recurrence within three months of treatment, before the fibrinolytic system became normal. In one patient the fibrinolytic defect reappeared after 10 months in spite of continued treatment. Two of the three women of fertile age developed irregular cycles and intermenstrual bleeding, which disappeared when the treatment was withdrawn. No other side effects were observed.
Archaebiotics
Authors: Jean-François Brugère, Guillaume Borrel, Nadia Gaci, William Tottey, Paul W O’Toole, Corinne Malpuech-Brugère
Journal: Gut Microbes (2013)

Trimethylamine (TMA) is produced by gut bacteria from dietary ingredients. In individuals with a hereditary defect in flavin-containing monooxygenase 3, bacterial TMA production is believed to contribute to the symptoms of trimethylaminuria (TMAU; fish-odor syndrome). Intestinal microbiota TMA metabolism may also modulate atherosclerosis risk by affecting trimethylamine oxide (TMAO) production levels. We propose that reducing TMA formation in the gut by converting it to an inert molecule could be used to prevent or limit these human diseases, while avoiding the major drawbacks of other clinical interventions. Reducing TMA levels by microbiological interventions could also be helpful in some vaginoses. Particular members of a recently discovered group of methanogens, that are variably present in the human gut, are unusual in being apparently restricted to utilizing only methyl compounds including TMA as substrates. We confirmed experimentally that one of these strains tested, Methanomassiliicoccus luminyensis B10, is able to deplete TMA, by reducing it with H2 for methanogenesis. We therefore suggest that members of this archaeal lineage could be used as treatments for metabolic disorders.
Randomised controlled trial of general practitioner intervention in patients with excessive alcohol consumption.
Authors: P. Wallace, S. Cutler, A. Haines
Journal: BMJ (1988)

To determine effectiveness of advice from general practitioners to heavy drinkers to reduce their excessive alcohol consumption (35 U or more a week for men, 21 U or more for women).Randomised, controlled double blind trial over 12 months with interim assessment at six months.Group practices (n = 47; list size averaging 10,000) recruited from Medical Research Council's general practice research framework, mostly in rural or small urban settings.Patients recruited after questionnaire survey. Of total of 2571 (61.2%) of 4203 patients invited for interview who attended, 909 (35.4%) stated that in past seven days they had drunk above the limits set for study and had not received advice; they were randomised to control and treatment groups.Patients in treatment group were interviewed by general practitioner (who had had a training session) and received advice and information about how to reduce consumption and also given a drinking diary.Study aimed at detecting a reduction in proportion of men with excessive alcohol consumption of 30% in treatment group and 20% in control group (for women 40% and 20%, respectively) with a power of 90% at 5% level of significance. In addition, corroborative measures such as estimation of gamma-glutamyltransferase activity were included.At one year a mean reduction in consumption of alcohol of 18.2 (SE 1.5) U/week had occurred in treated men compared with a reduction of 8.1 (1.6) U/week in controls (p less than 0.001). The proportion of men with excessive consumption at interview had dropped by 43.7% in the treatment group compared with 25.5% in controls (p less than 0.001). A mean reduction in weekly consumption of 11.5 (1.6) U occurred in treated women compared with 6.3 (2.0) U in controls (p less than 0.05), with proportionate reductions of excessive drinkers in treatment and control groups of 47.7% and 29.2% respectively. Reduction in consumption increased significantly with number of general practitioner interventions. At one year the mean value for gamma-glutamyltransferase activity had dropped significantly more in treated men (-2.4 (0.9)IU/l) than in controls (+1.1(1.0)IU/l; t = 2.7, p less than 0.01). Reduction in gamma-glutamyltransferase activity tended to increase with number of intervention sessions in men. Changes in gamma-glutamyltransferase activity in women and changes in other indicators in both sexes did not differ significantly between treatment and control groups.If the results of this study were applied to the United Kingdom intervention by general practitioners could each year reduce to moderate levels the alcohol consumption of some 250000 men and 67500 women who currently drink to excess. General practitioners and other members of the primary health care team should therefore be encouraged to include counselling about alcohol consumption in their preventive activities.
Tuberculosis and HIV: estimates of the overlap in England and Wales.
Authors: J M Watson, S K Meredith, E Whitmore-Overton, B Bannister, J H Darbyshire
Journal: Thorax (1993)

BACKGROUND: A study was designed to determine the extent of the interaction between tuberculosis and human immunodeficiency virus infection in England and Wales. METHODS: Data were obtained from the United Kingdom national AIDS surveillance and the Medical Research Council tuberculosis notification surveys in England and Wales (1983 and 1988). The proportion of patients reported with AIDS known to have had tuberculosis and the proportion of patients notified with tuberculosis known to have HIV infection were estimated. RESULTS: Of the 4360 patients with AIDS reported by 30 June 1991, 200 (4.6%) were in patients reported to have had tuberculosis. Only one of the 3002 patients (0.03%) reported in the 1983 survey of tuberculosis notifications in England and Wales was known to be infected with HIV compared with nine of 2163 patients (0.42%) in the 1988 survey. CONCLUSION: Although the reported number of cases of HIV infection with tuberculosis in this country is increasing it remains small. Complete reporting of cases of AIDS and notification of cases of tuberculosis are essential to enable the two infections to be monitored as the HIV epidemic develops. Special studies, such as those reported here, will need to be undertaken regularly to assess the future extent of the interaction.
Stress fracture of the hook of the hamate
Authors: A R Guha, H Marynissen
Journal: British Journal of Sports Medicine (2002)

Fractures of the hook of the hamate have rarely been reported. They have usually resulted from blunt trauma or a sharp strike against the hamate hook while swinging a golf club, baseball bat, or tennis racquet. Patients present with acute onset of pain localised over the ulnar aspect of the wrist and reduction in grip strength. In the case reported here, the patient complained of gradual onset of pain on the ulnar aspect of the wrist after altering his grip for serving in tennis. Once the diagnosis was made, the fracture was treated conservatively and the patient made a complete recovery.
Assessing levels of airborne bioallergens in New York City.
Authors: M R Pereira, E F Ferrand
Journal: Environmental Health Perspectives (1981)

Sampling of airborne ragweed and other pollen grains in the City of New York is described as it took place during the months of August and September 1973. Three sampling stations participated in the program. This effort was meant to serve as the forerunner of a citywide volunteer pollen sampling network based on the cooperation of existing health care providing institutions, schools, and stations of the operational sampling network of the New York City Department of Air Resources. Monitoring stations were set up on the roof of Cooper Union School of Engineering at 51 Astor Place in downtown Manhattan, at the Boyce Thompson Institute for Plant Research, Inc. at Yonkers, N.Y. and use was made of the data supplied by Middlesex General Hospital, New Brunswick, N.J. Seasonal results of ragweed pollen sampling, undertaken at the downtown New York City location of Cooper Union with the swing-shield intermittant rotoslide sampler, are similar to those of studies undertaken in the 1940's and 1950's with the Durham slide sampler in the New York metropolitan area. Comparison of the collected data with converted data obtained in 1979 at Long Island Jewish-Hillside Medical Center with the aid of a Durham gravity slide sampler shows the trend similarity of the data collected by us in 1973 and those obtained in 1979. Collected data of the 1973 ragweed season were supplied to the New York City news media on a daily basis, as a much appreciated service to the public.
784-4 Older Donor Age Predicts Increased Risk for Coronary Vasculopathy in the Year Following Transplantation: Serial Examination by Intravascular Ultrasound
Authors: E. Murat Tuzcu, Anthony C. De Franco, Ellen Mayer, David J. Moliterno, Robert E. Hobbs, Corrine Bott- Silverman, Robert W. Stewart, Patrick M. McCarthy, Skip Guyer, Steven E. Nissen
Journal: Journal of the American College of Cardiology (1995)
The Case for Internal Medicine
Authors: F T Fitzgerald
Journal: New England Journal of Medicine (1993)

The failure to fill several prestigious medical house officerships in 1987 and the subsequent steady decline in interest in internal medicine among medical students has led, over the past five years, to convulsive self-examination by program directors and chairpersons of medicine departments. A flood of papers have imputed blame to factors ranging from venal changes in the character of modern medical students to excessively brutal training programs, with much reasoned thought and analysis between these two extremes. Whatever the reasons, it appears to be true that internal medicine, as a field, is in trouble. As one applicant for an internship . . .
AMINE FLUX SENSITIZATION DERMATITIS IN ELECTRICITY CABLE JOINTERS
Authors: K. D. CROW, R. R. M. HARMAN, H. HOLDEN
Journal: British Journal of Dermatology (1968)

Journal Article AMINE FLUX SENSITIZATION DERMATITIS IN ELECTRICITY CABLE JOINTERS K. D. CROW, K. D. CROW Princess Margaret Hospital, Swindon (Dr. Crow), United Bristol Hospitals (Dr. Harman), and British Insulated Callender's Cables (Dr. Holden) Search for other works by this author on: Oxford Academic Google Scholar R. R. M. HARMAN, R. R. M. HARMAN Princess Margaret Hospital, Swindon (Dr. Crow), United Bristol Hospitals (Dr. Harman), and British Insulated Callender's Cables (Dr. Holden) Search for other works by this author on: Oxford Academic Google Scholar H. HOLDEN H. HOLDEN Princess Margaret Hospital, Swindon (Dr. Crow), United Bristol Hospitals (Dr. Harman), and British Insulated Callender's Cables (Dr. Holden) Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 11, 1 November 1968, Pages 701–710, https://doi.org/10.1111/j.1365-2133.1968.tb11931.x Published: 01 November 1968 Article history Accepted: 24 July 1968 Published: 01 November 1968
LYMPHOCYTIC INFILTRATION OF THE SKIN (JESSNER).
Authors: C. D. CALNAN
Journal: British Journal of Dermatology (1957)

Journal Article LYMPHOCYTIC INFILTRATION OF THE SKIN (JESSNER). Get access C. D. CALNAN C. D. CALNAN Physician, St. John's Hospital for Diseases of the Skin, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 69, Issue 5, 1 May 1957, Pages 169–173, https://doi.org/10.1111/j.1365-2133.1957.tb13250.x Published: 01 May 1957
ADDRESS ON DIETETICS
Authors: E. A. WOOD
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRANSFUSION OF PLASMA
Authors: A. S. Wiener
Journal: JAMA (1941)

<h3>To the Editor:—</h3> I read with interest the report in a recent issue ofThe Journal(May 3, p. 2015) by Dr. Frank Mayner concerning a death following a transfusion of blood plasma. My purpose in this communication is to offer a possible explanation for the lethal reaction. In describing the collection of blood for the preparation of plasma, the author states that 50 cc. of 2.5 per cent sodium citrate was used for 450 cc. of blood, giving an effective concentration of sodium citrate of 0.25 per cent. This is the minimum concentration originally found effective for citrate transfusions by Dr. Lewisohn, whose idea in setting the concentration so low was to avoid the toxic effect of the citrate ion. It has since been found (1) that, while 0.25 per cent is sufficient for fresh blood transfusions, this concentration does not entirely prevent coagulation but merely retards it; (2)
Catheter ablation of the atrial myocardium in human type I atrial flutter.
Authors: N Saoudi, G Atallah, G Kirkorian, P Touboul
Journal: Circulation (1990)

To avoid atrioventricular node-His bundle ablation, catheter ablation of the atrial myocardium was attempted in eight patients with drug refractory type I atrial flutter. In seven of eight patients, a zone of prolongation and fragmentation of the endocardial electrogram was found in the low posterior part of the right atrium. Entrainment of the atrial flutter by high right atrial pacing was accompanied by local recording of second-degree regional block in several atrial sectors but never in the low septal area. We, therefore, hypothesized that the latter represented the critical slow conduction zone of the reentrant flutter circuit. One or two cathodal DC shocks were locally delivered without immediate or late complications. One single ablation attempt was performed in five patients, whereas three patients underwent a second attempt because of early flutter recurrence. Patients were initially discharged without (and after a second session with) antiarrhythmic drugs. After a mean follow-up of 15.5 months (range, 10-23 months), five patients are free of arrhythmias without antiarrhythmic drug therapy. Two patients did not experience atrial arrhythmias while on a drug regimen that was previously found to be ineffective, and a third patient had flutter recurrences. This study suggests that patients with type I atrial flutter referred for atrioventricular node-His bundle ablation may be successfully managed by delivering the ablative shock directly on the atrial arrhythmia substrate.
Efficacy of Pertussis Vaccines: A Brighter Horizon
Authors: N. W. Preston, T. N. Stanbridge
Journal: BMJ (1972)

A study of pertussis infections in 186 children under 11 years of age in the Manchester region during 1969-71 suggests that recently-manufactured vaccines have been more effective than those made before 1967. The earlier vaccines were effective mainly against the serotypes of <i>Bordetella pertussis</i> possessing antigen 2, while those made from 1967 are more nearly equal in their effectiveness against thedi fferent serotypes. A booster dose of the earlier vaccines did not prevent infection with type 1,3 organisms, but we obtained a positive culture from only one child who had received four doses of recent vaccine. Simultaneous infection of a child with two or more serotypes was frequently seen. The predominant serotype in a patient was usually type 1,3; less often it was type 1,2,3 or type 1,2; it was never type 1. A change of serotype sometimes occurs during the course of the illness and is probably directed by the vaccination status of the patient in relation to the serotype of the initial infection. Our findings emphasize the need for vaccines to contain adequate amounts of all three pertussis agglutinogens, and for satisfactory immunization schedules to be used in their administration.
Riluzole for the Treatment of Amyotrophic Lateral Sclerosis -- Too Soon to Tell?
Authors: Lewis P. Rowland
Journal: New England Journal of Medicine (1994)

When it comes to announcing an effective treatment for a currently untreatable disease, investigators have a grave responsibility. Bensimon et al.1 report in this issue of the Journal that riluzole, a glutamate antagonist, increased survival in one group of patients with amyotrophic lateral sclerosis (ALS) but was not helpful in another group of patients with the same disease. Therein lies a medical mystery.The cause of sporadic ALS is not known. A familial form accounts for about 5 percent of all cases and, in about 40 percent of the families, can be mapped to the gene for superoxide dismutase on . . .