tbuckley/cabot-search huggingface dataset:
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Authors: WILLIAM OSLER
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pure Red-Cell Aplasia and Epoetin Therapy
Authors: Charles L. Bennett, Stefano Luminari, Allen R. Nissenson, Martin S. Tallman, Stephen A. Klinge, Norene McWilliams, June M. McKoy, Benjamin Kim, E. Allison Lyons, Steve M. Trifilio, Dennis W. Raisch, Andrew M. Evens, Timothy M. Kuzel, Glen T. Schumock, Steven M. Belknap, Francesco Locatelli, Jerôme Rossert, Nicole Casadevall
Journal: New England Journal of Medicine (2004)

Between 1988 and 1998, antibody-associated pure red-cell aplasia was reported in three patients who had undergone treatment with recombinant human erythropoietin (epoetin). Between 1998 and 2000, 13 such cases were reported from France — 12 in patients who had received the Eprex formulation of epoetin alfa and 1 in a patient who had received Neorecormon (a formulation of epoetin beta); both are products that are marketed outside the United States.
Conflicts Regarding Decisions to Limit Treatment
Authors: Susan Dorr Goold, Brent Williams, Robert M. Arnold
Journal: JAMA (2000)

Conflicts between physicians and families about end-of-life decisions create challenging and emotionally difficult situations. In this article, we propose a "differential diagnosis" of such conflicts, distinguishing and describing the characteristics of families, physicians, and organizations and society that contribute to the "etiology" of the situation, as well as strategies for "diagnosing" the dominant factors. As a medical model, the differential diagnosis can be a useful tool to help physicians understand and manage conflicts about end-of-life care.
ARE FORCE ASYMMETRIES MEASURED IN JUMP TESTS ASSOCIATED WITH PREVIOUS INJURY IN PROFESSIONAL FOOTBALLERS?
Authors: D Cohen, N Clarke, S Harland, C Lewin
Journal: British Journal of Sports Medicine (2014)

Background In female athletes, bilateral aysmmetry in peak landing forces during the drop jump is associated with anterior cruciate ligament (ACL) injury risk and is proposed as a marker of rehabilitation progression following ACL rupture. Less is known regarding the value of the assessment of these asymmetry in jump tasks in relation to recovery from other lower extremity injuries, particularly in male athletes. Objective To evaluate the association between previous injury and bilateral limb asymmetry in peak ground reaction forces during a countermovement jump (CMJ) and a drop jump (DJ). Design Retrospective study. Setting Professional football club. Participants 24 first team players. Risk factor assessment CMJ and DJ performed on two force platforms placed side by side with one foot on each platform. Main outcome measurements Asymmetry in peak force during the take-off and landing phases of a CMJ countermovement jump in healthy players who either had (INJ) or had not (N-INJ) sustained a non-contact lower extremity injury in the preceding season. Results Compared to N-INJ, P-INJ mean asymmetry in P-INJ was CMJ takeoff force was 8% higher (CMT-a), in landing force (CML-a) 57% higher, in DJ first landing (DJ1-a) and second landing (DJ2-a) 11% and 31% higher, respectively. None of these differences were significant, but based on Cohen's d , the difference between INJ and N-INJ in CML-a was large (d=0.65), in DJ2-a was moderate (d=0.39) and in CMT-a and DJ1-a was small (d=0.13 and d=0.28, respectively). Conclusions Our findings suggest that in pro footballers jump landing force asymmetry both in CMJ and DJ may be a marker of residual deficits associated with previous lower extremity injury. Larger studies are needed to confirm these findings and to determine whether these asymmetries may also be a marker of future injury risk.
F-18 FDG PET/CT in the Assessment of Recurrent Anaplastic T-Cell Lymphoma of the External Auditory Canal
Authors: Osama Gomaa, Aldo N. Serafini, Elizabeth Franzmann, Muaiad Kittaneh, Naomi Montague, Dimitrios Kalkanis
Journal: Clinical Nuclear Medicine (2010)

We report a case of pathologically proven recurrent cutaneous anaplastic T-cell lymphoma of the ear. The patient had been previously treated with local radiotherapy 3 years prior. Recently, the patient presented with worsening pain and swelling of the left external auditory meatus. The patient underwent a workup, which included clinical, radiologic, and pathologic correlation. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography confirmed metabolically active disease in the primary lesion and local lymph node involvement, which was subsequently proven to be recurrent anaplastic T- cell lymphoma.
Capillary pressure estimates from arterial and venous occlusion in intact dog lung
Authors: M Corboz, S Sanou, FA Grimbert
Journal: European Respiratory Journal (1995)

We performed pulmonary venous occlusions in order to check the validity of the pulmonary capillary pressure measurements obtained using pulmonary arterial occlusion in the intact animal. The venous and arterial postocclusion pressure profiles were recorded using balloon catheters introduced, respectively, into a left lower lobe vein and into a right pulmonary artery in the anaesthetized open-chest dog. The pressure profiles were fitted by a biexponential function with an early exponential and a late exponential presenting, respectively, a short and a long time constant. We used the zero-time extrapolation of the late slow exponential to obtain an arterial (Pc,ao) and a venous (Pc,vo) estimate of the pulmonary capillary pressure. Each Pc,ao and Pc,vo made it possible to calculate a fractional arterial or venous pressure gradient when referenced to the arteriovenous pressure gradient measured during the occlusion process. In nine dogs, when referenced to the whole lung, the arterial, middle and venous fractional pressure gradients were 37 +/- 11, 10 +/- 6, and 53 +/- 12%, respectively. As the middle fractional pressure gradient is low, we conclude that pulmonary capillary pressure estimates from arterial occlusion are close to the venous occlusion estimates of capillary pressure in the intact dog lung.
Effects of exercise and CO2 inhalation on intersubject variability in ventilatory and heart rate responses to progressive hypoxia
Authors: F Sato, M Nishimura, T Igarashi, M Yamamoto, K Miyamoto, Y Kawakami
Journal: European Respiratory Journal (1996)

Although the ventilatory and heart rate responses to hypoxia are known to vary widely among subjects, it is not known how exercise or hypercapnia influence the intersubject variability of these responses. If the intersubject variability increases under such conditions, the inherent response of individuals will have more impact on ventilation and heart rate under a variety of hypoxic conditions during exercise or with hypercapnia than at rest or with normocapnia. Seventeen healthy male volunteers underwent tests to measure ventilatory response to isocapnic progressive hypoxia three times respectively: at rest; during CO2 inhalation (end-tidal carbon dioxide tension (PET,CO2) raised by 5 torr from the baseline level); and during mild exercise with a cycle ergometer (12.5 W) in a supine position. The mean (SEM) value of hypoxic ventilatory response (HVR) (delta minute ventilation (V'E)/delta arterial oxygen saturation (Sa,O2) was significantly increased both in the exercise and hypercapnic runs compared with that in the control run (0.45 +/- 0.12, 0.34 +/- 0.08, respectively, vs 0.12 +/- 0.02 L.min-1/% fall), although the respiratory pattern was different under the two loaded conditions. The intersubject variation in HVR was also significantly increased during the two loaded conditions compared with the control, although a significant correlation remained between the control value and that obtained during either loaded condition (r = 0.66 and r = 0.60, respectively). The heart rate (HR) response evaluated by the slope factor (delta HR/delta Sa,O2) was not significantly different either in the mean value or in the intersubject variability among the three experimental conditions. In conclusion, exercise or CO2 inhalation not only increase the slope value of HVR but also amplify the intersubject variability of the response. In contrast, the HR response to hypoxia evaluated as a slope factor does not change with exercise or CO2 inhalation.
Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation
Authors: Jorge Cortes, Jeff H. Lipton, Delphine Rea, Raghunadharao Digumarti, Charles Chuah, Nisha Nanda, Annie-Claude Benichou, Adam R. Craig, Mauricette Michallet, Franck E. Nicolini, Hagop Kantarjian
Journal: Blood (2012)
Effects of Nurse Management on the Quality of Heart Failure Care in Minority Communities
Authors: Jane E. Sisk, Paul L. Hebert, Carol R. Horowitz, Mary Ann McLaughlin, Jason J. Wang, Mark R. Chassin
Journal: Annals of Internal Medicine (2006)

Background: Despite therapies proven effective for heart failure with systolic dysfunction, the condition continues to cause substantial hospitalization, disability, and death, especially among African- American and other nonwhite populations. Objective: To compare the effects of a nurse-led intervention focused on specific management problems versus usual care among ethnically diverse patients with systolic dysfunction in ambulatory care practices. Design: Randomized effectiveness trial conducted from September 2000 to September 2002. Setting: The 4 hospitals in Harlem, New York. Patients: 406 adults (45.8% were non-Hispanic black adults, 32.5% were Hispanic adults, 46.3% were women, and 36.7% were ≥65 years of age) who met eligibility criteria: systolic dysfunction, English- or Spanish-language speakers, community-dwelling patients, and ambulatory care practice patients. Intervention: During a 12-month intervention, bilingual nurses counseled patients on diet, medication adherence, and self-management of symptoms through an initial visit and regularly scheduled follow-up telephone calls and facilitated evidence-based changes to medications in discussions with patients' clinicians. Measurements: Hospitalizations (in 406 of 406 patients during follow-up) and self-reported functioning (in 286 of 406 patients during follow-up) at 12 months. Results: At 12 months, nurse management patients had had fewer hospitalizations (143 hospitalizations vs. 180 hospitalizations; adjusted difference, −0.13 hospitalization/person-year [95% CI, −0.25 to −0.001 hospitalization/person-year]) than usual care patients. They also had better functioning: The Short Form-12 physical component score was 39.9 versus 36.3, respectively (difference, 3.6 [CI, 1.2 to 6.1]), and the Minnesota Living with Heart Failure Questionnaire score was 38.6 versus 47.3, respectively (difference, −8.8 [CI, −15.3 to −2.2]). Through 12 months, 22 deaths occurred in each group and percentages of patients who were hospitalized at least once were similar in each group (30.5% of nurse management patients vs. 36.5% of control patients; adjusted difference, −7.1 percentage points [CI, −16.9 to 2.6 percentage points]). Limitations: Three nurses at 4 hospitals delivered interventions in this modest-sized trial, and 75% of the participants were from 1 site. It is not clear which aspects of the complex intervention accounted for the results. Conclusions: Nurse management can improve functioning and modestly lower hospitalizations in ethnically diverse ambulatory care patients who have heart failure with systolic dysfunction. Sustaining improved functioning may require continuing nurse contact.
Esophacoil Expanding Stent in the Management of Patients with Nonresectable Malignant Esophageal or Cardiac Neoplasm:A Prospective Study
Authors: None Olsen, None Thyregaard, None Kill
Journal: Endoscopy (1999)

In this prospective study we evaluated the use of the self-expanding Esophacoil stent for palliation in patients with non-resectable malignant tumors of the cardia and esophagus. The stent has some obvious advantages from a theorectical point of view, namely a wide diameter and strong forces of expansion and retraction, which prevent migration and tumor overgrowth. Its considerable flexibility facilitates insertion of the stent into tortuous and angulated passages.A total of 30 patients participated in the study. The tumor was located in the lower esophagus or cardia in 15 patients, in the mid-esophagus in six and in the upper oesophagus in two patients. More than two-thirds of the esophagus was involved in three patients and four had a recurrence in an esophagogastric anastomosis.The procedure was successful in 29 of 30 patients. The overall hospital mortality was 10%. One death from gastrointestinal haemorrhage following insertion of the stent was directly procedure-related. The morbidity related to the procedure was 10%. The median time in hospital after stent insertion was 1 day (range 1-9). All the patients could manage a semi-solid diet after stent insertion. Survival after discharge did not exceed 8 months and the median survival was 63 days. Of the patients, 22 (81 %) needed no further intervention or hospital admission because of the stents. Three had tumor overgrowth or ingrowth, and one stent migrated after the patient was discharged and passed spontaneously per anum.Insertion of an Esophacoil metal stent into malignant strictures of the esophagus and cardia is a fairly simple and safe procedure. Dysphagia is significantly relieved, initially, with few long-term side effects. In the short span of time left for the patients, the need for further treatment after discharge is minimal, but swallowing ability gradually deteriorates in the terminal phase.
Coordination games, anti-coordination games, and imitative learning
Authors: Roger A McCain, Richard Hamilton
Journal: Behavioral and Brain Sciences (2014)

Abstract Bentley et al.'s scheme generates distributions characteristic of situations of high and low social influence on decisions and of high and low salience (“transparency”) of rewards. Another element of decisions that may influence the placement of a decision process in their map is the way in which individual decisions interact to determine the payoffs. This commentary discusses the role of Nash equilibria in game theory, focusing especially on coordination and anti-coordination games.
Atrial Fibrillation Due to Hiatal Hernia.
Authors: M. Leo Hughes
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Atrial Fibrillation Due to Hiatal Hernia.M. Leo Hughes Jr., M.D., F.A.C.P., Lucius D. Hill, M.D.M. Leo Hughes Jr., M.D., F.A.C.P.Search for more papers by this author, Lucius D. Hill, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-834_5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecurrent episodes of atrial fibrillation occuring in five patients for 2 or more years were abolished by surgical repair of symptomatic hiatal hernia. The radiographically demonstrated hiatal hernia had been refractory to medical management for 1 or more years. Free or induced gastric acid reflux was demonstrated by gastroesophageal pH and pressure studies, and esophagitis was seen on esophagoscopy. Selective coronary arteriograms were normal. Blood pressure determinations, chest X rays, thyroid studies, and electrocardiograms (without the arrhythmia) were normal.A characteristic history was episodes of epigastric fullness and acid regurgitation followed by the onset of rapid atrial fibrillation with a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Wash. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFurther Assessment of Atrial Fibrillation as a Risk Factor for Gastroesophageal Reflux Disease: A Multicenter Questionnaire SurveyGastroesophageal Reflux Disease – Another Risk Factor for Atrial Fibrillation?Treatment of the Bradycardia-Tachycardia Syndrome with Permanent Demand Pacing 1 May 1971Volume 74, Issue 5Page: 834-835KeywordsAtrial fibrillationBlood pressureElectrocardiographyGastroenterology and hepatologyGastroesophageal reflux diseaseHerniaStable coronary artery diseaseSurgical repairThoraxThyroid Issue Published: 1 May 1971 PDF DownloadLoading ...
Shared Medical Decision Making
Authors: Robert A. McNutt
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ROENTGEN RAY IN THE DIAGNOSIS OF PERFORATED PEPTIC ULCER
Authors: R. T. VAUGHAN
Journal: JAMA (1925)

Air, free in the peritoneal cavity, has long been considered a valuable sign in the diagnosis of perforations of the gastro-intestinal tract, but this important sign has not gained the popularity that it deserves because of the uncertainty with which its presence was formerly elicited by percussion, particularly when the air was present in small volume.  The possibility of demonstrating free intraperitoneal air by the roentgen ray suggested itself to us as a more accurate and reliable method than by percussion of the liver dulness. There was also the possibility that the air could be visualized at a much earlier stage after perforation than by the older method. A study of the literature on this subject revealed several brief references to the roentgen-ray detection of air in the peritoneal cavity, but no reports could be found in which the sign was studied in a large series of cases in relation
THE CONGENITAL FACTOR IN CHRONIC RENAL DISEASE
Authors: DWARD WEISS
Journal: JAMA (1922)

The purpose of this report is to record briefly the clinical notes and pathologic findings in three uncommon cases of chronic renal disease occurring in comparatively young persons, associated with a marked degree of nitrogen retention and running a rapidly fatal course. In addition, because of the absence of a definite etiologic factor, together with an unusual appearance of the kidneys at necropsy, the importance of a congenital basis is emphasized, as an etiologic factor in these and similar cases. <h3>REPORT OF CASES</h3><h3>Case 1.1</h3> —J. M., a white man, aged 37, a policeman for the last fifteen years, who was admitted to the Jefferson Hospital in the service of Dr. H. A. Hare, April 12, 1921, complained of shortness of breath. His family history was negative. He had had typhoid fever at 13, gonorrhea at 22 and influenza at 33, from all of which he had apparently made
Violence in G-Rated Animated Films
Authors: Fumie Yokota
Journal: JAMA (2000)

various media suggest that videocassette viewing is an important source of entertainment for children.A recent report by the Kaiser Family Foundation indicates that 96% of young children (ages 2-7 years) live in homes with at least 1 videocassette recorder, and 16% have a videocassette recorderintheirownbedroom. 1 Theyoung children in the study reported spending nearly 2 hours per day watching television and an additional half hour per day watching commercially prerecorded videotapes. 1 In a similar study by the Annenberg Public Policy Center, parents of young children (ages 2-5 years) reported that their children watched an average of 2.2 hours per day of television and 1.5 hours per day of videotapes. 2 In 1998, 5 of the top 10 best-selling videos in the United States were animated features rated G (for general audiences) by the Motion Picture Association of America (MPAA). 3Two recent studies of popular live-action films rated G and PG (parental guidance suggested) and likely to be seen by children found that firearms are "frequently shown" 4 and that injury prevention practices and consequences of injuries are poorly portrayed. 5To our knowledge, no analysis quantified or characterized violent content in Grated animated feature films.This study systematically compares the violent content of these animated films.
Esophageal Disorders: Pathophysiology and Therapy
Authors: Alvin M. Cotlar
Journal: JAMA (1985)

There appears perhaps once every decade a medical textbook of the high quality represented by DeMeester and Skinner's edited collection of papers from the 1983 International Symposium on Esophageal Disorders. This compendium of diagnosis and management of esophageal disease addresses state-of-the-art diagnosis and treatment without ignoring the logical influence of previous theory and practice. The early chapters provide a scholarly consideration of functional anatomy and physiology of the esophagus, with a comprehensive discussion of motility and sphincter pressure. Diagnostic advances are discussed, which include imaging, computed tomography, radionuclide studies, and pH monitoring. The logical progression to consideration of gastroesophageal reflux follows, with excellent papers describing comparison studies of the various techniques of operative repair. Additional chapters are devoted to the more complicated surgical problems such as failed antireflux procedures, stricture, and carcinoma. The nonsurgical subjects of functional esophageal disorders, varices, and endoscopy are equally well presented. The editors and contributors
Poor leadership is blamed for financial problems in NHS
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

Inadequate leadership at board level or ineffective management—and on some occasions both—have led to the serious financial problems seen in some NHS bodies, says England's public spending watchdog.

Key people, including chief executives and finance directors, taking their “eye off the ball” and being distracted by other business, such as building projects, have led to “a lack of robust budget-setting” and poor accounting, says the Audit Commission in a report on financial failure in NHS organisations in England published this week.

For its report the commission reviewed 25 organisations that had been the …