tbuckley/cabot-search huggingface dataset:
Immunodeficiency with hyperimmunoglobulinemia M in two female patients is not associated with abnormalities of CD40 or CD40 ligand expression
Authors: A OLIVA, I QUINTI, E SCALA, E FANALESBELASIO, L RAINALDI, M PIERDOMINICI, A GIOVANNETTI, R PAGANELLI, F AIUTI, F PANDOLFI
Journal: Journal of Allergy and Clinical Immunology (1995)
Objective Estimates of the Probability of Death from Burn Injuries
Authors: Colleen M. Ryan, David A. Schoenfeld, William P. Thorpe, Robert L. Sheridan, Edwin H. Cassem, Ronald G. Tompkins
Journal: New England Journal of Medicine (1998)

Over the past 20 years, there has been remarkable improvement in the chances of survival of patients treated in burn centers. A simple, accurate system for objectively estimating the probability of death would be useful in counseling patients and making medical decisions.
Variation and Inappropriateness Are Not the Same-Reply
Authors: Lucian L. Leape
Journal: JAMA (1990)

<h3>In Reply.—</h3> Dr Mark raises important questions that need to be answered concerning the relationship of appropriateness to population-based use rates. It is true that we found inappropriate use accounted for 28% of the variance in the use of coronary angiography, but we also noted that if one county with a very high use rate was excluded the correlation became insignificant. Further, no significant correlation was found for either of the other two procedures studied. We think it is fitting to conclude that the correlation between appropriateness and use is weak, and in the only instance where a positive and significant one was found, it was not stable. We agree with Dr Mark that no one<i>should</i>"seriously believe[s] that surgery rates should all be the same," but as he notes, in the analysis of geographic variations, "Inappropriate utilization has always been the implied culprit." Unfortunately, hundreds of thousands of
Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus
Authors: Leland J. Yee, Yong-Ming Tang, David E. Kleiner, Dai Wang, KyungAh Im, Abdus Wahed, Xiaomei Tong, Shannon Rhodes, Xiaowen Su, Margaret R. Whelan, Robert J. Fontana, Marc G. Ghany, Brian Borg, Jake T. Liang, Huiying Yang
Journal: Hepatology (2007)

Abstract Candidate genes, including myxovirus resistance-1 (Mx1), protein kinase (PKR), transforming growth factor - β 1 (TGF-β), interleukin-10 (IL-10), and interferon-gamma (IFN-γ), were evaluated for associations with liver fibrosis in 374 treatment-naive patients with genotype-1 chronic HCV infection [194 Caucasian Americans (CAs) and 180 African Americans (AAs)], using a genetic haplotype approach. Among the 18 haplotypes that occurred with a frequency ≥5% in the cohort overall, the Mx1-(-123C)-(+6886A)-(+19820G(379V))-(+38645T) (abbreviated Mx1-CAGT), and PKR-(+110T)-(+7949G)-(+13846A)-(+22937T)-(+40342T) (abbreviated PKR-TGATT) haplotypes were independently associated with less severe hepatic fibrosis (Ishak ≥ 3 versus &lt;3). These associations persisted after adjustment for potential confounders such as alcohol use, sex, age (which is strongly correlated with the estimated duration of HCV infection [Spearman's correlation coefficient ( r s) = 0.6)], and race (for Mx1-CAGT : OR = 0.33; 95% CI: 0.16-0.68; P = 0.0027; and for PKR-TGATT : OR = 0.56; 95% CI: 0.32-0.98; P = 0.0405). Population structure was evaluated using the structured association method using data from 161 ancestry-informative markers and did not affect our findings. We used an independent cohort of 34 AA and 160 CA in an attempt to validate our findings, although notable differences were found in the characteristics of the two patient groups. Although we observed a similar protective trend for the Mx1-CAGT haplotype in the validation set, the association was not statistically significant. Conclusion: In addition to other factors, polymorphisms in cytokine genes may play a role in the progression of HCV-related fibrosis; however, further studies are needed. (HEPATOLOGY 2007.)
A NOVEL METABOLICALLY ACTIVE ANTIANGINAL AGENT (TRIMETHAZIDINE) ENHANCES PET MEASURED GLUCOSE UTILIZATION
Authors: F Vaghaiwalla Mody, K. B Coyle, H. W Hansen, D. B. Buxton, R. Sumida, B. N Singh, H. R Schelbert
Journal: Clinical Nuclear Medicine (1995)

Mody, F Vaghaiwalla; Coyle, K. B; Hansen, H. W; Buxton, D. B.; Sumida, R.; Singh, B. N; Schelbert, H. R Author Information
P1-04-01: The Mechanism of Anti-Breast Cancer TICs Effect of Pyrvinium Pamoate Is through WNT/beta-Catenin Signaling.
Authors: W Xu, B Debeb, A de Lacerda, L Li, R Larson, J Reuben, N Ueno, W Woodward
Journal: Cancer Research (2011)

Abstract We have previously shown that pyrvinium pamoate can decrease breast cancer TICs in vitro and shrink the tumor size in vivo. Although pyrvinium pamoate has been shown to target beta-catenin through activating CK-1alpha in a vitro model, the mechanism of its anti-breast cancer TICs effect is unknown. Herein, we use a constitutively active WNT/beta-catenin signaling construct EBETAP (ref) to determine if the anti-breast TIC effect of pyrvinium pamoate is through WNT/beta-catenin signaling. Using aldefluor expression and mammosphere formation efficiency as TIC surrogate assays, we found that TICs of SUM-159 transfected with EBETAP construct are resistant to pyrvinium pamoate treatment compared to control cells. Moreover, microarray analysis reveals a series of genes and signaling downstream of WNT-catenin were down-regulated in SUM-159 cells treated with pyrvinium pamoate. In summary, mechanism of anti-breast cancer TICs effect of pyrvinium pamoate is through WNT/beta-catenin signaling. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P1-04-01.
Wrinkles More Than Cancer
Authors: ANTONIO NAVARRETE
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 May 1972Wrinkles More Than CancerANTONIO NAVARRETE, M.D.ANTONIO NAVARRETE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-834_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have read with interest Dr. Daniel's recent paper, "Smoker's Wrinkles," in the ANNALS OF INTERNAL MEDICINE (75:873-880, 1971).My experience makes me share Dr. Daniel's belief in a possible relation between smoking and facial wrinkles. Whatever the causes of the association, this relation deserves further investigation for its prophylactic potential, considering that, human nature being what it is, fear of wrinkles may prove to be a stronger deterrent than fear of cancer to the smoker with self-induced tidal air pollution.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: James O. Parramore Hospital Crown Point, Ind. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 834-834KeywordsAir pollutionFear ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Funding the End-Stage Renal-Disease Program
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1982)

Funding the End-Stage Renal-Disease ProgramThe Reagan administration, in a climate in which federal budget cutting is the overriding priority, is moving to implement policy changes in the End-Stage Renal-Disease (ESRD) Program that were approved by Congress in the Omnibus Budget Reconciliation Act of 1981. The act directs the Department of Health and Human Services (DHHS) to craft a new dual-rate reimbursement system that differentiates between hospital-based and free-standing dialysis facilities, promotes home dialysis, and strives for greater efficiency in a program that will cost $1.8 billion in fiscal 1982.The manner in which the administration implements these somewhat conflicting . . .
DIAGNOSTIC VALUE OF THE DEEP REFLEXES OF THE LOWER EXTREMITIES.
Authors: D. S. FAIRCHILD
Journal: JAMA (1900)

The diagnostic ability of railway surgeons is not inquently taxed to its utmost in determining the real [ill] in cases of alleged organic disease of the spinal [ill] in which paralysis is presented as a symptom. The forms of paralysis complained of are either motor or sensory, or both. Spastic forms, with or without trophic conditions, may be left out of consideration for the present at least, as they present features which make them easy of recognition. In a case of motor or sensory paralysis, or both comined, the questions which will enter the mind of the examiner are three in number: 1. Is the paralysis due to an organic change in the anterior or motor side of the spinal cord, or both in anterior and posterior sides, or are the lines of communication impaired or destroyed by injury to, or disease of, the afferent or efferent nerve-fibers, or both?
Teaching Evidence-Based Medicine in Resource-Limited Countries
Authors: Kameshwar Prasad
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypercoagulability Associated with Malignancy and the Postoperative State: Evidence of Elevated Antihemophilic Globulin-like Activity (AHG).
Authors: M. A. Amundsen
Journal: Annals of Internal Medicine (1962)

s1 April 1962Hypercoagulability Associated with Malignancy and the Postoperative State: Evidence of Elevated Antihemophilic Globulin-like Activity (AHG).M. A. Amundsen, M.D., J. A. Spittell Jr., M.D., F.A.C.P., J. H. Thompson Jr., Ph.D., C. A. Owen Jr., M.D.M. A. Amundsen, M.D.Search for more papers by this author, J. A. Spittell Jr., M.D., F.A.C.P.Search for more papers by this author, J. H. Thompson Jr., Ph.D.Search for more papers by this author, C. A. Owen Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-683_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBecause accelerated thromboplastin generation has been demonstrated by the "retarded" thromboplastin generation test (TGT), in certain persons with arterial and venous thrombosis, a study was made of the coagulation changes occurring in the postoperative state and in association with malignant lesions, two conditions in which thromboembolism is known to occur.Twenty-five subjects with normal thromboplastin generation underwent a variety of surgical procedures. In each case, accelerated thromboplastin generation occurred by the sixth postoperative day. Thromboplastin generation also was evaluated in a group of 30 patients with malignant lesions which included tumors of the breast, lung, and abdominal viscera. Thromboplastin generation... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minn. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPulmonary Emboli in Patients Receiving Chemotherapy for Non-Hodgkin's LymphomaHemostatic abnormalities associated with malignant diseasesParaneoplastic syndromes Resulting from elaboration of ectopic hormones, antigens and bizarre toxinsExtrapulmonary effects of cancer of the lung and pleuraHypercoagulability with MalignancyReferencesCarcinoma of the lung, including systemic manifestationsExtrathoracic Manifestations of Bronchogenic CarcinomaA review of unusual systemic manifestations associated with carcinomaHemorrhage and thromboses associated with neoplastic disorders 1 April 1962Volume 56, Issue 4Page: 683-683KeywordsLesionsLungsThrombosisVenous thromboembolism Issue Published: 1 April 1962 PDF DownloadLoading ...
Differentiating between audit and research: postal survey of health authorities' views
Authors: A. Wilson, G. Grimshaw, R. Baker, J. Thompson
Journal: BMJ (1999)

Access to patients and their records for non-clinical purposes has recently come under scrutiny.1 Research ethics committees control access for research purposes, but audit is explicitly excluded from their remit.2 Although there is consensus that locally organised audits do not need ethical approval, the status of larger scale audits designed to influence broader practice remains unclear; some journals do not publish papers based on clinical audit data if they do not have ethical approval.3 Guidelines published by the Royal College of Physicians suggest submission to a research ethics committee if doubt exists about whether a project is audit or research.4

We recently completed a national audit of screening for diabetic retinopathy The aim of the audit was to identify factors associated with screening coverage and to provide baseline data for local audit cycles. The study involved …
Recent Progress in Hormone Research: Proceedings of the 1962 Laurentian Hormone Conference. Vol XIX.
Authors: Dwight J. Ingle
Journal: JAMA (1963)

Comparative Endocrinology. Vol 1: Glandular Hormones. Edited by U. S. von Euler and H. Heller. 543 pp. $20. Academic Press, 111 Fifth Ave, New York 3, 1963
Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2
Authors: Christoph Schliemann, Alessandro Palumbo, Kathrin Zuberbühler, Alessandra Villa, Manuela Kaspar, Eveline Trachsel, Wolfram Klapper, Hans Dietrich Menssen, Dario Neri
Journal: Blood (2008)
De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch
Authors: Beata Bielinska, Susan M. Blaydes, Karin Buiting, Tao Yang, Malgorzata Krajewska-Walasek, Bernhard Horsthemke, Camilynn I. Brannan
Journal: Nature Genetics (2000)
Ultrasound Surveillance to Detect Postoperative Venous Thrombosis
Authors: F. Kayser Enneking
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I appreciate the tremendous effort of Francis et al<sup>1</sup>in comparing warfarin and external pneumatic compression for prevention of venous thrombosis after total hip replacement. I wonder, however, why they did not explore the effect of intraoperative anesthetic management. Regional anesthesia, either epidural or subarachnoid block, reduces the incidence of postoperative thromboembolism during total hip arthroplasty.<sup>2,3</sup>The mechanism by which intraoperative thrombosis occurs is probably related to increased regional blood flow, a by-product of local anesthetic-induced sympathectomy, and to a mild effect on the acute hemostatic reaction to surgery.<sup>4</sup>Thus, regional anesthesia modulates two branches of Virchow's triad of stasis, hypercoagulability, and intimal damage. Francis et al seemed to have ignored this body of literature by providing data on the incidence of venous thrombosis related only to the type of thrombosis prophylaxis and not to the type of anesthesia also.
Characterization of bovine serum albumin epitopes and their role in allergic reactions
Authors: P. Restani, C. Ballabio, A. Cattaneo, P. Isoardi, L. Terracciano, A. Fiocchi
Journal: Allergy (2004)

This review provides updated information on conformational and sequential epitopes identified in bovine serum albumin (BSA) and summarizes available data about the role of structural modifications on BSA antigenicity/allergenicity.Data on beef allergy and BSA antigenicity are reported, with reference both to the basic literature and to clinical results obtained by our group.BSA is an important allergen involved in milk and beef allergy. The presence of conformational epitopes has been suggested by indirect evidence, while at least one sequential epitope has been experimentally identified. The role of structural modifications on BSA antigenicity is discussed as well as the increased tolerance observed in allergic subjects consuming beef as strained (homogenized) and freeze-dried derivatives.Study of the molecular characteristics of a known major allergen allows the identification of technological processes that may be capable of improving the tolerance of allergic subjects to a specific food. Even though any hoped for reduced allergenicity must be verified under medical supervision, the use of new products could obviate the need to avoid important foods such as meat in childhood.
Low-Dose Intradermal Hepatitis B Vaccine
Authors: Jules L. Dienstag
Journal: JAMA (1986)

<h3>To the Editor.—</h3> In a recent report from the Walter Reed Army Institute of Research, Redfield and colleagues<sup>1</sup>presented the results of a study in which 2 μg of hepatitis B vaccine administered intradermally (ID) to 25 health workers was compared with the standard 20-μg dose administered intramuscularly (IM) to another 25 health workers. Based on similar seroconversion rates and antibody levels achieved, these investigators concluded that the low-dose ID regimen was comparable in immunogenicity with the IM regimen. Obviously, if ID administration requires one-tenth the dose of the IM route, the potential savings in vaccine costs would make this vaccine more affordable and, therefore, more available than it is now. For the military, already under budgetary pressure to limit spending, the dollar savings for a mass vaccination program of military personnel rotating for brief tours of duty through high-risk areas of the world would be substantial. On the
Blood banks give HTLV-III test positive appraisal at five months
Authors: Charles Marwick
Journal: JAMA (1985)

nation's blood supply is measurably safer than it was five months ago—at least as far as the risk of transmitting the acquired immunodeficiency syndrome (AIDS) is concerned. This is the conclusion from experience to date with the tests for human T-cell lymphotropic virus type III (HTLV-III) antibody being used by blood banks to screen out potentially AIDS-infected blood.  Data from experience with the tests were reported at a meeting held in Bethesda, Md, at the National Institutes of Health in association with the Food and Drug Administration (FDA), Rockville, Md, and the Centers for Disease Control, Atlanta. The general impression is that, after the first five months, these tests are doing an extremely good job of screening potentially AIDS-infectious blood units out of the blood supply, said Harry M. Meyer, Jr, MD, director of the Center for Drugs and Biologics at the FDA.   HTLV-III or lymphadenopathy-associated virus (LAV)
TCT-171 J-DESsERT 3-Year Outcomes: Largest randomized trial stratified by diabetes mellitus presence, comparing sirolimus and paclitaxel eluting stents.
Authors: Masato Nakamura, Toshiya Muramatsu, Hiroyoshi Yokoi, Hisayuki Okada, Masahiko Ochiai, Satoru Suwa, Yutaka Matsuyama, Shinsuke Nanto
Journal: Journal of the American College of Cardiology (2013)
Potential Contribution of a Novel Antifibrotic Factor, Hepatocyte Growth Factor, to Prevention of Myocardial Fibrosis by Angiotensin II Blockade in Cardiomyopathic Hamsters
Authors: Yoshiaki Taniyama, Ryuichi Morishita, Hironori Nakagami, Atsushi Moriguchi, Hiroshi Sakonjo, None Shokei-Kim, Kunio Matsumoto, Toshikazu Nakamura, Jitsuo Higaki, Toshio Ogihara
Journal: Circulation (2000)

Background —Because hepatocyte growth factor (HGF) prevented and/or regressed fibrosis in liver and pulmonary injury models, HGF may play an important role in the pathogenesis of fibrotic cardiovascular disease. Because angiotensin (Ang) II significantly decreased local HGF production, we performed (1) in vitro experiments using fibroblasts and (2) administration of an ACE inhibitor (temocapril) and an Ang II type 1 receptor antagonist (CS-866) to cardiomyopathic hamsters. Methods and Results —In human fibroblasts, HGF significantly increased the production of matrix metalloprotease-1 (MMP-1) and urokinase plasminogen activator, whereas HGF also significantly attenuated the reduction of MMP-1 activity induced by Ang II. In contrast, HGF significantly decreased transforming growth factor (TGF)-β mRNA stimulated by Ang II, whereas HGF also decreased basal TGF-β protein level without affecting growth. Similarly, in rat cardiac fibroblasts, HGF inhibited the expression and production of TGF-β, whereas HGF upregulated its specific receptor, c-met. Conversely, in vivo experiments revealed that administration of temocapril and CS-866 to cardiomyopathic hamsters resulted in a significant decrease in fibrotic area and increase in cardiac HGF concentration and mRNA ( P &lt;0.01), whereas cardiac concentration and mRNA of HGF were significantly decreased in cardiomyopathic hamsters. In contrast, mRNA expression of collagen III was markedly decreased by treatment with temocapril and CS-866. Conclusions —Here, we demonstrated that Ang II blockade prevented myocardial fibrosis in the cardiomyopathic hamster, accompanied by a significant increase in cardiac HGF. Overall, increase in local HGF expression may participate in the prevention of myocardial injury by Ang II blockade through its antifibrotic action.
Unusual haemolytic-uraemic syndrome.
Authors: E N Wardle
Journal: BMJ (1979)

In February 1978 the patient went skiing with his school colleagues, and being afraid of taking drugs in the presence of his friends he stopped taking his immunosuppressive therapy for two weeks.Seen again at the end of March 1978 he was azotaemic, with a plasma creatinine of 884 ,umol/l (10-0 mg/100 ml).An open biopsy of the transplant showed the signs of an acute interstitial graft rejection.Under high-dose steroids administered in addition to his continuous immunosuppressive regimen the graft function improved again, and since June 1978 the plasma creatinine is stable at about 256 tmol/l (2 9 mg/100 ml).
What happened to plain wickedness?
Authors: R. Lefever
Journal: BMJ (2000)

Last Friday someone burnt my house down. He was not a patient of mine, nor even an acquaintance. I can only guess at his motive. I suspect it was a result of something going on inside his own head rather than anything to do with me or my family. As far as ownership of the property is concerned, I anticipate that it could just as easily have been your house that was torched to the ground as mine.

Nobody died or was injured. Even the cats got out. We are “fully covered” by insurance, although our broker has already told us of inevitable discrepancy between theory and practice.

> The metal frame of the piano looks bizarre without its rosewood case 

I weep for my books, my wife's loss of her mother's cut glass, and all the family photographs and trinkets. And the watercolours. And the little dolls our daughter made by painting faces on wooden clothes pegs when she was 8.

It's …
Hepatitis B virus variant, with a deletion in the preS2 and two translational stop codons in the precore regions, in a patient with hepatocellular carcinoma
Authors: Giovanni Raimondo, Salvatore Campo, Vincenzo Smedile, Giuseppina Rodino, Maria Adriana Sardo, Santa Brancatelli, Daniela Villari, Maurizio Pernice, Giuseppe Longo, Giuseppe Squadrito
Journal: Journal of Hepatology (1991)