Fansidar Prophylaxis of Pneumocystis Pneumonia in the Acquired Immunodeficiency Syndrome
Authors: MARGARET A. FISCHL
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 October 1986Fansidar Prophylaxis of Pneumocystis Pneumonia in the Acquired Immunodeficiency SyndromeMARGARET A. FISCHL, M.D., GORDON M. DICKINSON, M.D.MARGARET A. FISCHL, M.D.Search for more papers by this author, GORDON M. DICKINSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-4-629_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor:Pneumocystis cariniipneumonia is a major cause of morbidity and mortality in patients with the acquired immunodeficiency syndrome (AIDS). More than 50% of patients with AIDS develop P. carinii pneumonia, and despite therapy more than 16% die with overwhelming infection. Several studies have shown that the combination of trimethoprim-sulfamethoxazole is effective in the treatment and prevention of P. carinii infection (1, 2). However, its use in patients with AIDS has been associated with a high incidence of adverse reactions (3). The report of Hardy and colleagues (4) that Fansidar (sulfadoxine-pyrimethamine; Hoffmann-LaRoche Inc., Nutley, New Jersey) taken once...References1. HUGHES W, MCNABB P, and MAKRES P. Efficacy of trimethoprim-sulfamethoxazole in the prevention and treatment of Pneumocystis carinii pneumonitis. Antimicrob Agents Chemother. 1974;5:289-93. CrossrefMedlineGoogle Scholar2. HUGHES W, KUHN S, and CHAUDHARY S. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med. 1986;297:1419-26. CrossrefGoogle Scholar3. GORDIN F, SIMON G, WOFSY C, and MILLS J. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1984;100:495-9. LinkGoogle Scholar4. HARDY D, WOLFE P, and GOTTLIEB M. Fansidar prophylaxis for Pneumocystis carinii pneumonia (PCP). In: Abstracts from the International Conference on Acquired Immunodeficiency Syndrome, 14-17 April 1985, Atlanta, Georgia. Philadelphia: American College of Physicians; 1985:25. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARGARET A. FISCHL, M.D.; GORDON M. DICKINSON, M.D.Affiliations: The University of Miami School of Medicine Miami, FL 33101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProphylaxe der Pneumocystis carinii Pneumonie bei Aids-PatientenErythema Multiforme, Stevens-Johnson Syndrome, and Toxic Epidermal NecrolysisEffective alternates to trimethoprim-sulfamethoxazole as antimicrobial prophylaxis in stem cell recipients: Are there any?Pneumocystis carinii and Parasitic Infections in the Immunocompromised HostTwice-weekly Pyrimethamine–sulfadoxine Effectively Prevents Pneumocystis carinii Pneumonia Relapse and Toxoplasmic Encephalitis in Patients with AIDSPrevention of Infection Due to Pneumocystis cariniiA controlled trial of dapsone versus pyrimethamine-sulfadoxine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmosis in patients with AIDSToxidermies et infection par le VIHPneumocystis carinii and Parasitic Infections in the Immunocompromised HostEfficacy of pyrimethamine/sulfadoxine in the prevention of toxoplasmic encephalitis relapses andPneumocystis carinii pneumonia in HIV-infected patientsProphylaxis of Pneumocystis carinii pneumonia in patients with HIV infectionPneumocystosisA Controlled Study of Inhaled Pentamidine for Primary Prevention of Pneumocystis carinii PneumoniaAerosol pentamidine prophylaxis following Pneumocystis carinii pneumonia in AIDS patients: Results of a blinded dose-comparison study using an ultrasonic nebulizerPrimary Prophylaxis against Common Infectious Diseases in Persons with Human Immunodeficiency Virus InfectionAerosol pentamidine prophylaxis following pneumocystis carinii pneumonia in AIDS patients: Results of a blinded dose-comparison study using an ultrasonic nebulizerToxic epidermal necrolysis (Lyell syndrome)Erythema multiforme major in a 2-month-old child with human immunodeficiency virus (HIV) infectionProphylaxie orale de la pneumocystose pulmonaireAerosolised pentamidine for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome‘Opportunistic’ and Other Parasitic Infections in Relation to the Acquired Immune Deficiency Syndrome (AIDS)Cutaneous manifestations of aids in adults and infantsPREVENTION OF PNEUMOCYSTIS CARINII PNEUMONIA RELAPSE BY PENTAMIDINE AEROSOL IN ZIDOVUDINE-TREATED AIDS PATIENTSThe Acquired Immunodeficiency SyndromeAIDS — Medizinische, epidemiologische und psychosoziale FaktorenTraitement et prophylaxie de la pneumocystose au cours du syndrome d'immunodeficience acquiseDrug Information Analysis ServiceTreatment of Infections Associated with Human Immunodeficiency VirusFansidar and Pneumocystis carinii PneumoniaP.H.J. FRISSEN, M.D., A. STRONKHORST, M.D., J.K.M. EEFTINCK SCHATTENKERK, M.D., S.A. DANNER, M.D.Current problems in the management of AIDS patients 1 October 1986Volume 105, Issue 4Page: 629-629KeywordsAIDSAdverse reactionsMorbidityMortalityPneumocystisPneumocystis carinii pneumoniaPneumoniaProphylaxis ePublished: 1 December 2008 Issue Published: 1 October 1986 PDF downloadLoading ...