Severe Vitamin D Deficiency: A Prerequisite for COPD Responsiveness to Vitamin D Supplementation?
Authors: Diane R. Gold, JoAnn E. Manson
Journal: Annals of Internal Medicine (2012)

Editorials17 January 2012Severe Vitamin D Deficiency: A Prerequisite for COPD Responsiveness to Vitamin D Supplementation?Diane R. Gold, MD, MPH and JoAnn E. Manson, MD, DrPHDiane R. Gold, MD, MPHFrom Brigham and Women's Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, MA 02215.Search for more papers by this author and JoAnn E. Manson, MD, DrPHFrom Brigham and Women's Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, MA 02215.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-2-201201170-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Chronic obstructive pulmonary disease (COPD) ranks in the top 10 causes of morbidity and mortality in the United States and in affluent and middle-income countries worldwide. According to the Global Initiative for Chronic Obstructive Lung Disease (www.goldcopd.org), extrapulmonary manifestations of COPD include muscle weakness, osteoporotic fractures, deep venous thrombosis, systemic inflammation, cardiovascular disease, and lung cancer and often contribute to disease severity and poor prognosis. Three-year follow-up in the TORCH (Towards a Revolution in COPD Health) study demonstrated that only one third of deaths were due to respiratory failure; the majority was attributed to lung cancer or cardiovascular events (1, ...References1. Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, et al; TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med. 2007;356:775-89. [PMID: 17314337] CrossrefMedlineGoogle Scholar2. Janssens W, Lehouck A, Carremans C, Bouillon R, Mathieu C, Decramer M. Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act. 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Vitamin D status and longitudinal lung function decline in the Lung Health Study. Eur Respir J. 2011;37:238-43. [PMID: 20595151] CrossrefMedlineGoogle Scholar8. Kunisaki KM, Niewoehner DE, Connett JE; for the COPD Clinical Research Network. Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study. Am J Respir Crit Care Med. 2011;:. [PMID: 22077070] MedlineGoogle Scholar9. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:53-8. [PMID: 21118827] CrossrefMedlineGoogle Scholar10. Institute of Medicine. Committee to Review Dietary Reference Intakes for Vitamin D, Calcium. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Pr; 2011. Google Scholar11. Lehouck A, Mathieu C, Carremans C, Baeke F, Verhaegen J, Van Eldere J, et al. High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease. A randomized trial. Ann Intern Med. 2012;156:105-14. LinkGoogle Scholar12. Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, et al; COPDGene Investigators. Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology. 2011;261:274-82. [PMID: 21788524] CrossrefMedlineGoogle Scholar13. Bossé Y, Lemire M, Poon AH, Daley D, He JQ, Sandford A, et al. Asthma and genes encoding components of the vitamin D pathway. Respir Res. 2009;10:98. [PMID: 19852851] CrossrefMedlineGoogle Scholar14. Raby BA, Lazarus R, Silverman EK, Lake S, Lange C, Wjst M, et al. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med. 2004;170:1057-65. [PMID: 15282200] CrossrefMedlineGoogle Scholar15. Dimeloe S, Hawrylowicz C. A direct role for vitamin D-binding protein in the pathogenesis of COPD? [Editorial]. Thorax. 2011;66:189-90. [PMID: 21233481] CrossrefMedlineGoogle Scholar16. DIPART (Vitamin D Individual Patient Analysis of Randomized Trials) Group. Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ. 2010;340:b5463. [PMID: 20068257] CrossrefMedlineGoogle Scholar17. Glendenning P, Zhu K, Inderjeeth C, Howat P, Lewis JR, Prince RL. Effects of three monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility and muscle strength in older postmenopausal women: a randomised controlled trial. J Bone Miner Res. 2011;:. [PMID: 21956713] MedlineGoogle Scholar18. Smith H, Anderson F, Raphael H, Maslin P, Crozier S, Cooper C. Effect of annual intramuscular vitamin D on fracture risk in elderly men and women—a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology (Oxford). 2007;46:1852-7. [PMID: 17998225] CrossrefMedlineGoogle Scholar19. Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010;303:1815-22. [PMID: 20460620] CrossrefMedlineGoogle Scholar20. Manson JE, Bassuk SS, Lee IM, Cook NR, Albert MA, Gordon D, et al. The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials. 2011;:. [PMID: 21986389] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Diane R. Gold, MD, MPH; JoAnn E. Manson, MD, DrPHAffiliations: From Brigham and Women's Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, MA 02215.Grant Support: The authors' work on vitamin D, COPD, and asthma is funded by the National Institutes of Health (R01 HL101932 and U01 CA138962).Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-2794.Corresponding Author: JoAnn E. Manson, MD, DrPH, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue, 3rd Floor, Boston, MA 02215; e-mail, [email protected]bwh.harvard.edu.Current Author Addresses: Dr. Gold: Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115.Dr. Manson: Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue, 3rd Floor, Boston, MA 02215. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHigh Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease An Lehouck , Chantal Mathieu , Claudia Carremans , Femke Baeke , Jan Verhaegen , Johan Van Eldere , Brigitte Decallonne , Roger Bouillon , Marc Decramer , and Wim Janssens Severe Vitamin D Deficiency: A Prerequisite for Chronic Obstructive Pulmonary Disease Responsiveness to Vitamin D Supplementation? Andrew Grey , Mark Bolland , and Ian Reid Metrics Cited byLung VITAL: Rationale, design, and baseline characteristics of an ancillary study evaluating the effects of vitamin D and/or marine omega-3 fatty acid supplements on acute exacerbations of chronic respiratory disease, asthma control, pneumonia and lung function in adultsInnate Immune Modulation in Chronic Obstructive Pulmonary Disease: Moving Closer toward Vitamin D TherapyVitamin D and chronic obstructive pulmonary disease: hype or reality?Vitamin D: Exacerbations in Chronic Obstructive Pulmonary Disease (COPD)Nutrition: The vitamin D complexSevere Vitamin D Deficiency: A Prerequisite for Chronic Obstructive Pulmonary Disease Responsiveness to Vitamin D Supplementation?Andrew Grey, MD, Mark Bolland, PhD, and Ian Reid, MD 17 January 2012Volume 156, Issue 2Page: 156-157KeywordsAsthmaCardiovascular diseasesFallsLung and intrathoracic tumorsLungsMortalityPneumoniaSystemic diseasesVitamin DVitamin D deficiency ePublished: 17 January 2012 Issue Published: 17 January 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. 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