tbuckley/cabot-search huggingface dataset:
Cervical Cytology and Reimbursement Issues
Authors: Joseph H. Keffer
Journal: JAMA (1990)

To the Editor.—  While I agree with Dr Ohrt 1 that Medicare, with its requirement of direct billing, has taken an important step toward improving the economic incentive to provide quality testing, the current Medicare fee schedule does not provide clinical laboratories with adequate payment for these important services.  Papanicolaou smears are reimbursed on the basis of carrier-wide fee schedules under Medicare, ranging from a lowof $4.11 in Missouri to a national cap of $9.10 in California and Alaska. Even if these payments covered current costs of performing the test, which they do not, the cost of providing this service must increase. This will cause serious access problems in the future. The shortage of cytotechnologists and the resulting salary wars have already affected costs and turnaround time. Pending legislation, which provides Medicare coverage of Papanicolaou smear testing for the first time as a screening test, will further overwhelm the system.
An 80-Year-Old Man With Memory Loss
Authors: Eric B. Larson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Seizure Disorders Among Prisoners
Authors: Max Bader
Journal: JAMA (1978)

To the Editor.—  I concur with the general findings of King and Young (239:2674, 1978) related to prisoners and their seizure disorders. Based on my limited experience, the prevalence of prisoners receiving anticonvulsants in Seattle is undoubtedly equivalent to that in Illinois. However, two points must be recognized.   There is a tendency for prisoners to be overmedicated. Many prisoners who take anticonvulsants are probably not suffering from epilepsy. They continue to receive these drugs because no one has the inclination to reassess the need for them. In this day of frequent prisoner complaints about their medical care and common lawsuits related to violations of prisoners' rights, the jail physician is often subjected to abuse if he tries to readjust a prisoner's medications.  A high proportion (often more than half) of prisoners are alcoholics or addicts. It is my impression that most prisoners who take anticonvulsants are among this
Anti-A and Anti-B Antibodies in Children
Authors: O. T. Gartner, R. Gilbert, M. McDermott, S. Benovitz, A. M. Wolf
Journal: JAMA (1967)

<h3>To the Editor:—</h3> This is a report of studies of anti-A and anti-B titers in children in the age range of 3 to 36 months. Older studies were made by methods little used today.<sup>1-3</sup>Anti-A and anti-B titers may be helpful for comparative purposes when the diagnosis of hypogammaglobulinemia or agammaglobulinemia is under consideration. <h3>Materials and Methods:—</h3> Blood specimens sufficient in size for titrations were obtained whenever possible from children in cases of disputed paternity. All children appeared healthy at time of venipuncture. As adult controls, parents (or alleged parents) were tested in the same instances. Each serum sample was tested against fresh A<sub>1</sub>, fresh B, and fresh O cells, by mixing 0.1 cc of serum (or serum dilution) under test with 0.1 cc of 2% cell suspension in 0.9% sodium chloride, shaking, letting stand one minute at room temperature, centrifuging at 1,000 rpm for one minute, resuspending by gentle
The Senograph: New Tool For Cancer Detection
Authors: Theodore L. Orloff
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Cancer of the breast is a leading malignant disease among women. Early diagnosis should improve the chances of cure and reduce the mortality. Other investigators have shown that routine examination of women between the ages of 40 and 65 years revealed a significant number of cancers which would have been missed except for the use of mammography. Mammography is a soft tissue x-ray film technique that does not require the use of contrast media. Previous techniques resulted in greyish, flat x-ray films which provided insufficient contrast. In order to help the early detection of breast cancer a special unit has been developed for mammography (the Senograph). This unit provides exceptional contrast and fine detail for diagnosis. Small calcific deposits are well defined. The molybdenum target tube produces the ideal frequency in the region of 0.6 to 0.9 Angstroms in order to produce the optimum contrast. Film with
Response to Comment on: Morden et al. Further Exploration of the Relationship Between Insulin Glargine and Incident Cancer: A Retrospective Cohort Study of Older Medicare Patients. Diabetes Care 2011;34:1965-1971
Authors: Nancy E. Morden, Stephen K. Liu, Jeremy Smith, Todd A. Mackenzie, Jonathan Skinner, Murray Korc
Journal: Diabetes Care (2012)

We appreciate the discussion initiated by Badrick et al. (1) and thank them for the questions raised. In an ideal world, we would have a randomized trial with the enormous sample necessary to answer this question as well as decades of follow-up. In an imperfect world, our analysis reveals the experience of a significant fraction of U.S. patients with diabetes using insulin glargine over 3 years of observation.

Regarding our prevalent users cohort and fixed treatment group assignment, we acknowledged the reasonable but unproven assumption that our observed exposure reflects unobserved exposure, preceding 2006 (Part D inception). Under this assumption, assignment to treatment observed in the earliest observation window is the best exposure …
Intracellular Delivery of Peptide Nucleic Acid and Organic Molecules Using Zeolite‐L Nanocrystals
Authors: Alessandro Bertucci, Henning Lülf, Dedy Septiadi, Alex Manicardi, Roberto Corradini, Luisa De Cola
Journal: Advanced Healthcare Materials (2014)

The design and synthesis of smart nanomaterials can provide interesting potential applications for biomedical purposes from bioimaging to drug delivery. Manufacturing multifunctional systems in a way to carry bioactive molecules, like peptide nucleic acids able to recognize specific targets in living cells, represents an achievement towards the development of highly selective tools for both diagnosis and therapeutics. This work describes a very first example of the use of zeolite nanocrystals as multifunctional nanocarriers to deliver simultaneously PNA and organic molecules into living cells. Zeolite‐L nanocrystals are functionalized by covalently attaching the PNA probes onto the surface, while the channel system is filled with fluorescent guest molecules. The cellular uptake of the PNA/Zeolite‐L hybrid material is then significantly increased by coating the whole system with a thin layer of biodegradable poly‐L‐lysine. The delivery of DAPI as a model drug molecule, inserted into the zeolite pores, is also demonstrated to occur in the cells, proving the multifunctional ability of the system. Using this zeolite nanosystem carrying PNA probes designed to target specific RNA sequences of interest in living cells could open new possibilities for theranostic and gene therapy applications.
A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier
Authors: Rohidas Arote, Tae-Hee Kim, You-Kyoung Kim, Soon-Kyung Hwang, Hu-Lin Jiang, Ho-Hyun Song, Jae-Woon Nah, Myung-Haing Cho, Chong-Su Cho
Journal: Biomaterials (2006)
Abstract 2032: Regulation of MUC1 expression by activated EGFR and PPARγ in human uterine and pancreatic cancer cell lines
Authors: Neeraja Dharmaraj, Daniel D. Carson
Journal: Cancer Research (2011)

Abstract Many epithelial tumors including endometrial and pancreatic cancers, overexpress the high molecular weight, transmembrane mucin, MUC1, on their cell surface. Overexpression and aberrant glycosylation of MUC1 makes tumor cells poorly adherent, increases drug resistance and promotes cancer cell metastasis. MUC1 has three distinct domains: an extracellular domain (ECD) composed of a tandem repeat region rich in serine, threonine and proline; a transmembrane domain (TM) and; a short cytoplasmic tail domain (CT) involved in a variety of signal transduction events. Previous studies (Wang et al. 2010. Mol. Endocrinol. 24: 1368-1379) demonstrated that the Peroxisome Proliferator Activated Receptor γ (PPARγ) agonist, rosiglitazone severely inhibits progesterone stimulated MUC1 expression. Two independent approaches were used to determine if rosiglitazone as well as inhibitors of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase activity reduced MUC1 expression in the human uterine epithelial cell line, HES, the uterine adenocarcinoma cell line, HEC-1A, and in the human pancreatic adenocarcinoma cell lines, HPAFII and CAPAN2. EGFR activation by Epidermal Growth Factor (EGF) stimulated (1.5-2 fold) MUC1 protein expression 1.5-2.0 fold in both uterine and pancreatic cancer cells, while treatment with EGFR tyrosine kinase inhibitor, AG1478, reduced both basal and stimulated MUC1 protein expression. Furthermore, the PPARγ agonist, rosiglitatzone, markedly (&amp;gt; 90%) reduced EGFR-driven MUC1 expression detected by antibodies directed against the MUC1 ECD and CT. A combination of biochemical and molecular biological assays have been used to identify the transcriptional and signal transduction pathways activated by EGFR leading to increased MUC1 expression and the impact of AG1478 and rosiglitazone on these events. Understanding the molecular basis of how these agents reduce MUC1 expression may offer novel therapeutic avenues to improve cancer chemotherapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2032. doi:10.1158/1538-7445.AM2011-2032
Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human
Authors: Michel Kielar, Françoise Phan Dinh Tuy, Sara Bizzotto, Cécile Lebrand, Camino de Juan Romero, Karine Poirier, Renske Oegema, Grazia Maria Mancini, Nadia Bahi-Buisson, Robert Olaso, Anne-Gaëlle Le Moing, Katia Boutourlinsky, Dominique Boucher, Wassila Carpentier, Patrick Berquin, Jean-François Deleuze, Richard Belvindrah, Victor Borrell, Egbert Welker, Jamel Chelly, Alexandre Croquelois, Fiona Francis
Journal: Nature Neuroscience (2014)
RELATION BETWEEN PRECIPITATING SITUATION AND OUTCOME IN MANIC-DEPRESSIVE PSYCHOSIS
Authors: Robert C. Hunt
Journal: American Journal of Psychiatry (1938)

1. In a series of 105 patients with manic-depressive psychosis, 67 did not have a serious precipitating situation, 15 had a serious situation which was relieved, and 23 had a serious situation which was not relieved. 2. In the group without a serious precipitating situation 73 percent recovered, with an average duration of 9.8 months. 3. In the group with a serious situation which was relieved all recovered, with an average duration of 9.4 months. 4. Recovery did not always take place at the time of the relief of the situation. 5.In the group with a serious situation which was not relieved 74 per cent recovered, with an average duration of 18.8 months.
Impact of bowel cancer screening on staging of bowel cancer
Authors: B. J. Johnston, M. Ali
Journal: Gut (2011)

<h3>Introduction</h3> The national Bowel Cancer Screening Programme (BCSP) aims to reduce mortality from bowel cancer by 16%. Screening started in Berkshire in May 2008. To achieve this it is hoped that screen detected cancers will be diagnosed at an earlier stage than those detected in the routine service. <h3>Methods</h3> A retrospective audit was carried out on all resection specimens received at one of the screening hospitals since the start of the BCSP. Cases were identified using the histopathology reporting system. Staging and tumour site information was gathered from the histopathology reports, referral route information from the cancer recording database and status in the BCSP from the bowel cancer screening computer system. Symptom profile for those patients with a positive FOBt was collected from the datasets collected at the colonoscopy assessment visit. <h3>Results</h3> Two hundred and sixty five patients had resections for cancer and the age at time of surgery ranged from 34.5 to 91.7 years. There were 146 male and 119 female patients. Of these 24 patients were referred through the BCSP following a positive FOBt (4 aged over 70 opt-ins), 3 patients had completed a FOBt with a negative result. 72 patients were in the age range covered by the BCSP and the Dukes staging in relation to their status within the programme is given in table 1 which shows a significantly increased number of Dukes A tumours in patients aged 60–70 with a positive FOBt in the BCSP (Chi squared test p &lt; 0.05). Eleven of the 20 FOBt positive patients aged 60–69 were symptomatic at the time of assessment within the programme. Three of the four over 70 opt-ins had symptoms with two Dukes B and two C1 tumours in this group <h3>Conclusion</h3> BCSP detected cancers are at a significantly earlier stage than those detected outside the programme. The three patients with a negative FOBt in the programme had more advanced tumours.
The Effect of Procaine Amide (Pronestyl) in Clinical Auricular Fibrillation and Flutter
Authors: G. MILLER, S. L. WEINBERG, A. PICK
Journal: Circulation (1952)

Procaine amide (Pronestyl) was administered to patients with auricular fibrillation and flutter in an attempt to restore sinus rhythm. Thirteen of 20 patients with auricular fibrillation had sinus rhythm re-established. Several of the patients who were not converted with procaine amide were later restored to sinus rhythm with quinidine.
Pituitary Enlargement Secondary to Untreated Primary Hypogonadism
Authors: BRUCE F. BOWER
Journal: Annals of Internal Medicine (1968)

A patient with isolated primary hypogonadism is presented in whom documented sella enlargement occurred over a 25-year period during which androgen replacement therapy was withheld. Similar less adequately documented case reports are summarized, and the experimental literature is reviewed. The possibility of pituitary enlargement secondary to hyperplasia or pituitary tumor induction in such patients as a result of failure to provide adequate replacement therapy is discussed.
New ventilation system can reduce deaths from acute respiratory distress syndrome
Authors: S. Gottlieb
Journal: BMJ (2003)

Patients who are critically ill with the serious lung condition known as acute respiratory distress syndrome sometimes die because organs other than their lungs begin to fail. The condition is then called multiple organ dysfunction syndrome.

Acute respiratory distress syndrome, which can result from pneumonia, trauma, sepsis, or other factors that cause injury to the lungs, typically triggers widespread inflammation and the build up of fluid in the lungs. About a third of patients who develop the condition die, but more than 60% of patients who go on to develop multiple organ dysfunction syndrome die.

In the past few years doctors have found that …
Crohn's disease with respiratory tract involvement.
Authors: M Lemann, B Messing, F D'Agay, R Modigliani
Journal: Gut (1987)

Symptomatic respiratory tract involvement with granulomatous bronchial lesions has not yet been described in Crohn9s disease. We report two patients with colonic Crohn9s disease and severe respiratory symptoms (dyspnoea associated in one of the patients with voicelessness); erythema, aphthoid and superficial ulcerations were found in the colon and whitish granulations in the bronchi at endoscopy. Non-caseating tuberculoid granulomas were found in the colonic mucosa of both patients, as well as in the bronchial mucosa of one of them; in the second a diffuse inflammatory infiltrate including epithelioid cells was found underneath an erosion of bronchial epithelium. Both patients improved on oral prednisone. These two patients probably had bronchial involvement by Crohn9s disease.
Policy on drug misuse in Europe
Authors: M Farrell, J Strang, J Neeleman, P Reuter
Journal: BMJ (1994)

Hospital staff need more education on substance misuse and its complications.A hospital based drug and alcohol counsellor assigned to work specifically with older people may help identify misusers, while regular medical audit of substance use could also improve detection and referral rates.Treatment should be based on a careful assessment and matching of each patient's needs to the range of treatment options available.Detoxification from alcohol may be indicated for some patients; others may need weaning off benzodiazepines, which may take weeks or months to achieve.Emphasis should be placed on non-drinking social activities in the context of the person's circumstances and social support networks.Individual counselling may be helpful for some elderly misusers, with a supportive and less con- frontational approach to treatment, or referral to Alcoholics Anonymous.Disulfiram should be used cautiously, under supervision, and only short term since there is a risk of precipitating a confusional state.Treatment specifically designed for elderly people may be more beneficial than programmes for mixed ages: older people frequently have concomitant medical and psychiatric illnesses and place heavier demands on health services.The most effective treatment may be that given through facilities that specifically serve elderly people.
Mandate for NHS reforms
Authors: S. Jenkins
Journal: BMJ (1992)

Mandate for NHS reforms SIR,-Where now for the BMA's policies on the NHS reforms?Concern that a market in health care would result not so much in managerial efficiency and a sensitivity to local needs but in winners and losers with widening gaps in the provision of health care led me to vote Labour.'2Although the general election was not a referendum on the reforms, the high profile of health as a pre-election campaign issue was as near as we are likely to get to one.The return of a Conservative government with a clear working majority means that a public mandate for the NHS reforms has been obtained, and I believe that the BMA should now put its full weight behind them.The purchaser-provider split will become a model not only for the NHS but for a wide range of centrally funded public services.Success in the United Kingdom will ensure that this model is exported to other countries, particularly in the expanding Europe.Recommending an enthusiastic and cooperative approach to the new political situation does not mean that we must cast aside our faculty for criticism.But criticisms must be more sharply focused.If individual patients are disadvantaged the reasons for that disadvantage must be examined rather than assumed and the finger pointed ac- curately at those responsible, be they the provider or the purchasing authority.Cooperation with management must not mean that the political pressure for better funding for the NHS should be abandoned.The exclusion of practising doctors from the management structure must regularly be
Rheumatoid Arthritis: Organ Manifestations and Complications
Authors: George E. Ehrlich
Journal: JAMA (1979)

This short monograph provides a rapid but reasonably thorough and up-to-date review of the various extra-articular sites and types of involvement in rheumatoid arthritis. Liberally illustrated, often in color, the booklet provides a good survey of the subject for the casual student of rheumatic diseases and contains much of value for the rheumatologist also. While a scientific rather than a commercial contribution, it is available free of charge from the pharmaceutical publisher by special request.
Autoantibodies against PDGF Receptor in Scleroderma
Authors: Filemon K. Tan
Journal: New England Journal of Medicine (2006)

Scleroderma (systemic sclerosis) is characterized by the deposition and accumulation of excessive amounts of collagen and extracellular-matrix molecules, the dysfunction of microvascular endothelial cells, and altered immune tolerance. These interacting and interdependent processes lead to chronic inflammation and tissue fibrosis.To investigate complex mechanisms of disease pathogenesis, conventional wisdom dictates that a single aspect of disease be dissected out and examined in detail. The skin is a prominent target organ in scleroderma, and fibroblasts from affected patients are activated and display a variety of properties, including increased production of collagens and other extracellular-matrix proteins, abnormal growth patterns, and resistance to . . .
A New Hope for Idiopathic Pulmonary Fibrosis
Authors: Gary M. Hunninghake
Journal: New England Journal of Medicine (2014)

I suspect that many of my patients have picked up on more than a hint of frustration in my voice when I tell them that the cause of their shortness of breath is idiopathic pulmonary fibrosis. This frustration stems from the fact that beyond providing information about prognosis or referral for lung transplantation or palliation, there has been little to offer in the way of treatment. Idiopathic pulmonary fibrosis is a chronic, progressive disorder of lung scarring that predominantly affects older patients and has a death rate worse than that of many cancers (3-year survival, 50%).1 However, in contrast to . . .
Of Toads and Flowers
Authors: DANIEL S. LUKAS
Journal: Circulation (1972)

Of Toads and Flowers M ANY CENTURIES before Withering studied the pharmacologic properties of purple foxglove, the Chinese were familiar with the medicinal powers of the dried, pow- dered skin of their indigenous toad Bufo bufo gargarizans.One of the compounds contained by the skin is the cardioactive steroid bufalin, which, aside from having five instead of four carbons in its lactone ring, is chemically similar to digitoxigenin, the simplest genin in the digitalis series.Over the ensuing years, the therapeutic use of the cardioactive steroids and their gylcosides grew increasingly sophisticated but, nevertheless, remained empirically oriented until recently because methods specific and sensitive enough for measuring those potent compounds in the body fluids and tissues of man were not available.The pioneering introduction of digitoxin labeled with 14car- bon,' the use of tritium-labeled compounds,2 and methods not dependent on the adminis- tration of radioisotopically labeled com- pounds, such as the double-isotope dilution derivative assays3 4 and the radioimmunoassays,5 have since yielded an extensive body of pharmacologic information concerning several cardiac glycosides.
Endocarditis Caused by Neisseria mucosa in Marfan's Syndrome
Authors: JOHN N. DOWLING
Journal: Annals of Internal Medicine (1974)

Neisseria mucosa is usually a commensal inhabitant of the oral mucous membranes. A 19-year-old man with Marfan's syndrome developed endocarditis that was caused by this organism 6 days after multiple dental extractions. It is likely that N mucosa bacteremia occurred during the extractions and seeded a mitral valve that was previously damaged by Marfan's syndrome. Penicillin prophylaxis at the time of dental extraction failed to prevent endocarditis.