tbuckley/cabot-search huggingface dataset:
An unusual adverse reaction to Ro 10-9359
Authors: K. Moulopoulou-Karakitsou, Myron Mavrikakis, M. Anastasiou-Nana
Journal: British Journal of Dermatology (1981)

Journal Article An unusual adverse reaction to Ro 10‐9359 Get access K. Moulopoulou‐Karakitsou, K. Moulopoulou‐Karakitsou Department of Clinical Therapeutics, University of Athens, ‘Alexandra’ Hospital, Vas.Sofias and Lourou St., Athens 611, Greece Search for other works by this author on: Oxford Academic Google Scholar Myron Mavrikakis, Myron Mavrikakis Department of Clinical Therapeutics, University of Athens, ‘Alexandra’ Hospital, Vas.Sofias and Lourou St., Athens 611, Greece Search for other works by this author on: Oxford Academic Google Scholar M. Anastasiou‐Nana M. Anastasiou‐Nana Department of Clinical Therapeutics, University of Athens, ‘Alexandra’ Hospital, Vas.Sofias and Lourou St., Athens 611, Greece Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 104, Issue 6, 1 June 1981, Page 709, https://doi.org/10.1111/j.1365-2133.1981.tb00760.x Published: 01 June 1981
Morbidity and mortality after minor bile duct injury following laparoscopic cholecystectomy
Authors: Klaske Booij, Philip de Reuver, Kenneth Yap, Susan van Dieren, Otto van Delden, Erik Rauws, Dirk Gouma
Journal: Endoscopy (2014)

<b>Background and study aims:</b> Cystic duct and Luschka duct leakage after laparoscopic cholecystectomy are often classified as minor injuries because the outcome of endoscopic stenting and percutaneous drainage is generally reported to be good. However, the potential associated early mortality and risk factors for mortality are scarcely reported. The aim of this study was to describe the outcome, mortality, and risk factors for poor survival of patients with type A bile duct injury (BDI) referred to a tertiary center. <b>Patients and methods:</b> Between January 1990 and January 2012, 800 patients were referred for BDI treatment and included in a prospective database. <b>Results: </b>Type A BDI, according to the Amsterdam and Strasberg classifications, was diagnosed in 216 patients. Treatment after referral was mainly endoscopic (n = 192 [88.9 %]) and radiologic (n = 14 [6.5 %]). Complications related to endoscopic retrograde cholangiopancreatography (ERCP) occurred in 14 patients (6.5 %). Other complications were sepsis (n = 34 [15.7 %]), cardiopulmonary (n = 22 [10.2 %]), and abscess formation (n = 15 [6.9 %]). BDI-related mortality was 4.2 % (9/216). Multivariate analysis showed age (hazard ratio [HR] = 1.04, 95 % confidence interval [CI] 1.00 – 1.07) and American Society of Anesthesiologists class 3 or 4 (HR = 5.64, 95 %CI 2.31 – 13.77) to be independent factors significantly associated with mortality. <b>Conclusions:</b> Type A "minor" BDI after laparoscopic cholecystectomy is associated with considerable short-term mortality related to the patient's condition at referral. Older patients and patients with ASA 3 or 4 have a significantly higher risk of mortality.
Abstract P1-13-11: Supervising circulating tumor cells during and beyond maintenance therapy with SERM or aromatase inhibitors. A way to better support our patients to make decisions in long-term survivorship
Authors: K Pachmann, C Rabenstein, O Camara, RB Ingo, P Ulrich
Journal: Cancer Research (2013)

Abstract Background: Although current guidelines still support 5 years of hormone blocking therapy after primary breast cancer due to earlier results showing no benefit of longer treatment, recent data have shown that longer treatment with tamoxifen can better reduce recurrence and death. However, side effects with this therapy can be considerable and compliance declines with time. We, here, report data on monitoring circulating epithelial tumor cells (CETC) beyond maintenance therapy showing that even if maintenance therapy with SERM or aromatase inhibitors had been effective in reducing tumor cells in blood, there can be a reincrease after the end of maintenance therapy and that this is highly correlated with relapse. Materials and methods: 7.5ml of anti-coagulated blood was drawn before the start of chemotherapy, after each cycle and after the end of chemotherapy. Using a nondissipative approach with only red blood cell lysis the white blood cells including the tumor cells were stained with a fluorescent labelled anti-epithelial antibody, positive events counted using an automated image analysis microscope and calculated per volume blood. Results: 96 patients with nonmetastatic breat cancer were observed beyond maintenance treatment with hormone blocking therapy. Results on CETC were evaluable from 35 patients even after completion of therapy. Increasing cell numbers after the end of therapy were able to predict relapsing from long term relapse free survivors (p = 0.0001). Conclusion: In breast cancer, a debate has been reiinitated with respect to the length of maintenane treatment. Even if hormone blocking maintenance treament is capable of reducing or even eliminating tumor cells circulating in peripheral blood and this is related to improved relapse free survival there may remain tumor cells in the body capable of regrowing and leading to late relapse. Monitoring of CETC in peripheral blood even after completion of maintenace therapy can early predict imminent relapse and help to decide whether to reinitiate hormone blocking therapy. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-13-11.
Case 31-1981
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Mark Hallett, Edward P. Richardson, Nancy L. Harris
Journal: New England Journal of Medicine (1981)

Presentation of CaseA 76-year-old woman was admitted to the hospital because of a neurologic disorder.She was well until two years earlier, when a tender nodule developed on the nasal bridge and gradually increased in size. Examination showed a firm mass, 2 cm in diameter, on the nasal bridge that was attached to the nasal cartilage and extended onto the right cheek. Physical examination was otherwise negative. A biopsy of the lesion revealed a poorly differentiated lymphocytic lymphoma. Radiation at a dose of 4000 rads was delivered to the nasal bridge, with disappearance of the lesion. She remained well . . .
Prognosis of Melanoma-Reply
Authors: D. Reintgen, H. F. Seigler
Journal: JAMA (1983)

<h3>In Reply.—</h3> Dr Silvers raises the question of whether black patients with melanoma, after controlling for the location of the melanoma lesion to volar and subungual primary sites, have a worse prognosis than their white counterparts. This question is indirectly answered in Table 2 of the article; we initially controlled for histology of the acral lentiginous type of lesion and subsequently constructed actuarial survival curves for the white and black populations. Acral lentiginous lesions are almost exclusively limited to the volar or subungual surfaces of patients with melanoma. In our black population, 22 patients had acral lentiginous histology, with 86% of these lesions present on palmar, plantar, or subungual locations. The remaining lesions were mucosal primary lesions that weretainedalso classified as acral lentiginous. The Figure shows median survival of 33.7 months in blacks and 110.7 months in whites with acral lentiginous melanomas. The<i>P</i>value for the difference in
The Standardized Bleeding Time as a Measure of Platelet Function In Vivo.
Authors: Sherrill J. Slichter
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972The Standardized Bleeding Time as a Measure of Platelet Function In Vivo.Sherrill J. Slichter, M.D., Laurence A. Harker, M.D.Sherrill J. Slichter, M.D.Search for more papers by this author, Laurence A. Harker, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-871_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe modified template Ivy bleeding time was evaluated as a test of in vivo platelet function in 79 selected patients with acquired and genetic platelet dysfunction. The bleeding time in 100 normal subjects averaged 4.5 minutes ± 1.7 (± 1 SD). In studies with aspirin, phenylbutazone, paraproteinemia, uremia, and von Willebrand's disease, prolongation of the bleeding time was both a more sensitive and reproducible test than a battery of in vitro function tests that included collagen adhesion; aggregation with adenosine diphosphate, adrenalin, collagen, thrombin; glass bead retention; platelet factor 3 (phospholipid); and clot retraction.In 27 patients with hypoproliferative thrombocytopenia,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Sherrill J. Slichter, M.D.; Laurence A. Harker, M.D.Affiliations: Seattle, Wash. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 871-871KeywordsAdenosine diphosphateAspirinGeneticsHemorrhagePhospholipidsPlateletsThrombinvon Willebrand disease ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Abstract 2823: Molecular response of the axillary lymph node microenvironment to metastatic colonization.
Authors: Rachel E. Ellsworth, Allyson L. Valente, Jennifer L. Kane, Darrell L. Ellsworth, Craig D. Shriver
Journal: Cancer Research (2013)

Abstract Breast stroma plays an active role in tumorigenesis, undergoing both phenotypic and molecular changes to facilitate and promote tumor development and growth. The metastatic microenvironment also plays a role in successful colonization; however, the genetic changes in these secondary microenvironments are not well described.To improve understanding of the molecular changes associated with metastatic colonization of a foreign tissue, gene expression data was generated from lymph node tissues from women with at least one lymph node with macrometastases and one lymph node with no detectable metastases. Lymph node tissue was microdissected and hybridized to U133A 2.0 gene expression arrays. Differential expression was detected using Partek® Genomics Suite™6.5 with P&amp;lt;0.001, &amp;gt;2-fold change defining significance. Thirty-four genes were differentially expressed, 23 genes, including EPCAM, KRT19 and MUC1, were expressed at significantly higher levels in colonized lymph nodes and 11 genes, such as CXCL2 and HPGDS, were expressed at significantly higher levels in non-metastatic lymph nodes. Thus, lymph node tissue differs in gene expression between those harboring metastatic tumors and those without metastasis. Genes expressed at higher levels in colonized lymph nodes are involved in tumorigenesis, suggesting that like the breast stromal microenvironment, the metastatic microenvironment undergoes cross-talk with the tumor cells, while genes involved in immune function are down-regulated in colonized lymph nodes, suggesting that suppression of proper immune response may be required for successful metastatic colonization. Citation Format: Rachel E. Ellsworth, Allyson L. Valente, Jennifer L. Kane, Darrell L. Ellsworth, Craig D. Shriver. Molecular response of the axillary lymph node microenvironment to metastatic colonization. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2823. doi:10.1158/1538-7445.AM2013-2823
Effective Treatment of Established Human Breast Tumor Xenografts in Immunodeficient Mice with a Single Dose of the α-Emitting Radioisotope Astatine-211 Conjugated to Anti-HER2/<i>neu</i> Diabodies
Authors: Matthew K. Robinson, Calvin Shaller, Kayhan Garmestani, Paul S. Plascjak, Kathryn M. Hodge, Qing-An Yuan, James D. Marks, Thomas A. Waldmann, Martin W. Brechbiel, Gregory P. Adams
Journal: Clinical Cancer Research (2008)

Abstract Purpose: Successful radioimmunotherapy strategies depend on selecting radioisotopes with physical properties complementary to the biological properties of the targeting vehicle. Small, engineered antitumor antibody fragments are capable of rapid, highly specific tumor targeting in immunodeficient mouse models. We hypothesized that the C6.5 diabody, a noncovalent anti-HER2 single-chain Fv dimer, would be an ideal radioisotope carrier for the radioimmunotherapy of established tumors using the short-lived α-emitting radioisotope 211At. Experimental Design: Immunodeficient nude mice bearing established HER2/neu–positive MDA-MB-361/DYT2 tumors treated with N-succinimidyl N-(4-[211At]astatophenethyl)succinamate (211At-SAPS)-C6.5 diabody. Additional cohorts of mice were treated with 211At-SAPS T84.66 diabody targeting the carcinoembryonic antigen or 211At-SAPS on a diabody specific for the Müllerian inhibiting substance type II receptor, which is minimally expressed on this tumor cell line. Results: A single i.v. injection of 211At-SAPS C6.5 diabody led to a 30-day delay in tumor growth when a 20 μCi dose was administered and a 57-day delay in tumor growth (60% tumor-free after 1 year) when a 45 μCi dose was used. Treatment of mice bearing the same tumors with 211At-SAPS T84.66 diabody at the same doses led to a delay in tumor growth, but no complete responses, likely due to substantially lower expression of this antigen on the MDA-MB-361/DYT2 tumors. In contrast, a dose of 20 μCi of 211At-SAPS on the anti–Müllerian-inhibiting substance type II receptor diabody did not affect tumor growth rate, demonstrating specificity of the therapeutic effect. Conclusions: These findings indicate that diabody molecules can be effective agents for targeted radioimmunotherapy of solid tumors using powerful, short-lived α-emitting radioisotopes.
Cigarette Smoking Is Associated With Low Glomerular Filtration Rate in Male Patients With Type 2 Diabetes
Authors: Kazumi Saito, Nobuhiro Yamada, Hirohito Sone
Journal: Diabetes Care (2007)

We read with interest the article by De Cosmo et al. (1) in the recent issue of Diabetes Care . The authors concluded from their cross-sectional data that cigarette smoking enhanced the risk of renal dysfunction in patients with type 2 diabetes despite …
Congenital Autoimmune Diabetes Mellitus
Authors: Corrado M. Cilio, Alessandro Bosco, Corrado Moretti, Loredana Farilla, Ferdinando Savignoni, Patrizia Colarizi, Giuseppe Multari, Umberto Di Mario, Giovanni Bucci, Francesco Dotta
Journal: New England Journal of Medicine (2000)

Hepatic Arterial Infusion of Chemotherapy for Metastatic Colorectal CancerTo the Editor: The study of hepatic arterial infusion of chemotherapy after resection of hepatic metastases in patients with colorectal cancer, reported by Kemeny et al. (Dec.30 issue), 1 represents a positive development in the management of colorectal cancer.However, clinicians planning to use this therapy may be confused by the dosages reported in the article.By convention, the dosage for hepatic intraarterial chemotherapy is based on the amount of drug delivered to the patient.Since infusion devices have variable flow rates and deliver only part of their contents in 14 days, the total dose of floxuridine placed in the device is much more than the dose the patient receives.Kemeny et al. state that the infusion pump was filled with "0.25 mg of floxuridine per kilogram of body weight per day for 14 days in combination with 20 mg of dexamethasone; 50,000 U of heparin, and enough normal saline to result in a volume of 50 ml."This does not mean that the dose delivered to patients was 0.25 mg per kilogram per day for 14 days.Because the average flow rate for these devices is approximately 2.0 ml per day, the dose of floxuridine that each patient received was about 0.14 mg per kilogram per day.Given the risk of hepatobiliary toxicity and the narrow therapeutic index for this treatment, 2 the dose of hepatic intraarterial floxuridine is a critical factor in the safe administration of regional chemotherapy.The dose of floxuridine should be based on the flow rate of the pump used to deliver the drug.
Regret and the control of temporary preferences
Authors: Terry Connolly, Jochen Reb
Journal: Behavioral and Brain Sciences (2005)

Regret is often symptomatic of the defective decisions associated with “temporary preference” problems. It may also help overcome these defects. Outcome regret can modify the relative utilities of different payoffs. Process regret can motivate search for better decision processes or trap-evading strategies. Heightened regret may thus be functional for control of these self-defeating choices.
RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model
Authors: John R. Mills, Abba Malina, Teresa Lee, Domenic Di Paola, Ola Larsson, Cornelius Miething, Frank Grosse, Hengli Tang, Maria Zannis-Hadjopoulos, Scott W. Lowe, Jerry Pelletier
Journal: Blood (2013)
Hepatic complications of erythropoietic protoporphyria
Authors: R.P.E. Sarkany, P.G. Norris
Journal: British Journal of Dermatology (1994)

Journal Article Hepatic complications of erythropoietic protoporphyria Get access R.P.E. Sarkany, R.P.E. Sarkany Departments of Dermatology, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.G. Norris P.G. Norris Departments of Medicine, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue 2, 1 February 1994, Pages 258–259, https://doi.org/10.1111/j.1365-2133.1994.tb02913.x Published: 01 February 1994
Improving survival after large bowel cancer.
Authors: T G Allen-Mersh
Journal: BMJ (1991)

degrees of synergy or an additive effect against H influenzae in vitro.17 8It is concentrated in tissues to a similar extent as roxithromycin and is taken up by human phagocytes.The clinical efficacy of clarithromycin has been confirmed against H infiuenzae and other pathogens causing a range of acute infections of the upper and lower respiratory tract acquired in the community, and the adverse reactions reported so far have been minor.19-2Its gastrointestinal side effects in particular seem less than those with erythromycin as judged by the results of double blind comparative trials.19What is the place of these new macrolides?The improved range of activity of clarithromycin, its twice daily administra- tion, and its lower frequency of gastrointestinal symptoms, suggest that it may be a suitable alternative to erythromycin for monotherapy of many respiratory infections acquired in the community.Further comparative studies against the widely prescribed 3-lactam drugs such as co-amoxyclav and the new oral cephalosporins are, however, needed before the optimal treatment can be determined for infections caused by H influenzae.The therapeutic consequences of the tissue penetration of compounds such as azithromycin also need elucidating.A decision on whether these new macrolides represent an important advance in the treatment of respiratory infections must therefore await the results of further studies.
Direct measurement of the rates of synthesis of plasma proteins in control subjects and patients with gastrointestinal protein loss
Authors: R. Dean Wochner, Sherman M. Weissman, Thomas A. Waldmann, Delores Houston, Nathaniel I. Berlin
Journal: Journal of Clinical Investigation (1968)

The guanido carbon of hepatic arginine is the common precursor of urea and of the arginine of plasma proteins synthesized in the liver. It is possible to measure the momentary synthetic rates of plasma proteins by "pulse labeling" this arginine pool with bicarbonate-(14)C. In the current study, this method has been adapted in order to use urinary urea data and was applied to control subjects and patients with gastrointestinal protein loss. The assumptions required for this determination are discussed. There was close agreement between albumin synthetic rates measured by this method and albumin catabolic rates derived from simultaneous albumin-(131)I studies, supporting the validity of the method and suggesting that there is relatively little fluctuation in the rate of albumin synthesis from time to time. The albumin synthetic rates in six control subjects averaged 5.8 mg/kg per hr, while those of five patients with gastrointestinal protein loss averaged 7.2 mg/kg per hr. Thus in these patients, there was relatively little acceleration of albumin synthesis in response to continued loss of plasma proteins into the gastrointestinal tract. Fibrinogen synthetic rates averaged 1.9 mg/kg per hr in five control subjects and 3.2 mg/kg per hr in five patients with gastrointestinal protein loss. Transferrin synthetic rates exhibited considerable individual variation in both groups and averaged 0.24 mg/kg per hr in four control subjects and 0.31 mg/kg per hr in five patients with gastrointestinal protein loss. The method employed in this study offers several advantages in studying plasma protein metabolism. It provides a direct measurement of protein synthesis, applicable to several proteins simultaneously, does not require a long-term steady state in the metabolism of the proteins, and is capable of measuring short-term fluctuations in synthetic rates. Therefore, this approach is applicable to the investigation of the physiological factors controlling the rates of synthesis for plasma proteins.
Hepatitis B antigen in ascitic fluid in cirrhosis.
Authors: L Cacciatore, V Molinari, V Guadagnino, P T Cataldo
Journal: BMJ (1973)

histological picture was characterized by a massive, almost syncytial growth of reticulum cells with many Reed-Stemnberg cells, severe lymphocyte depletion, and albsence of eosinophils, plasma cells, or fiibrinoid necrosis.This picture was completely differ- ent from the entity described as Hodgkin's sarcoma.Deelmant and I concluded that this disease could be described, both on clinical and on pathological grounds, as a separate entity.I had the opportunity to discuss these cases personally in 1955 with both Dr.F. Parker and Dr. R. J. Lukes, who were at that time rather sceptical about my pro- posal to mark off this disease from classic Hodgkin's disease as a separate subgroup.However, it should be borne in mind that in 1955 discussions about the immunological nature of Hodgkin's disease were still un- heard of.A good account of identical cases had already been given in 1953 by Miss
Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.
Authors: C H June, J A Ledbetter, P S Rabinovitch, P J Martin, P G Beatty, J A Hansen
Journal: Journal of Clinical Investigation (1986)

We evaluated CD2 (E rosette) and CD3 (T3)-triggered activation of resting lymphocytes by measuring the intracellular free calcium concentration ([Ca2+]i) of individual cells. The [Ca2+]i of indo-1-loaded cells was measured by flow cytometry and responses were correlated with cell surface phenotype. Stimulation with anti-CD3 antibody caused an increase in [Ca2+]i in greater than 90% of CD3+ cells within 1 min, and furthermore, the response was restricted to cells bearing the CD3 marker. In contrast, stimulation of cells with anti-CD2 antibodies produced a biphasic response pattern with an early component in CD3- cells and a late component in CD3+ cells. Thus, the CD2 response does not require cell surface expression of CD3. In addition, stimulation of a single CD2 epitope was sufficient for activation of CD3- cells, whereas stimulation of two CD2 epitopes was required for activation of CD3+ cells. Both the CD2 and CD3 responses were diminished in magnitude and duration by EGTA. However, approximately 50% of T cells still had a brief response in the presence of EGTA, indicating that the increased [Ca2+]i results in part from intracellular calcium mobilization, and furthermore demonstrates that extracellular calcium is required for a full and sustained response. Our results support the concept that CD2 represents the trigger for a distinct pathway of activation both for T cells that express the CD3 molecular complex and for large granular lymphocytes that do not.