Growth-Hormone-Releasing Hormone: A Clinical Update
Authors: Mary Lee Vance, Michael O. Thorner
Journal: Annals of Internal Medicine (1986)

Editorials1 September 1986Growth-Hormone-Releasing Hormone: A Clinical UpdateMARY LEE VANCE, M.D., MICHAEL O. THORNER, M.B., F.R.C.P.MARY LEE VANCE, M.D.Search for more papers by this author, MICHAEL O. THORNER, M.B., F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-3-447 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGrowth-hormone-releasing hormone (GHRH) is the most recent and last of the classical hypothalamic releasing hormones to be identified. The discovery and characterization of a new hormone affords the scientific and medical community the opportunity to address several questions of potential physiologic and practical importance, as the work with GHRH amply shows. First, it is necessary to determine the in-vitro and in-vivo action, specificity, interaction with other hormones, and any invivo adverse effects. If the hormone is shown to have diagnostic or therapeutic benefit, it may then be made available for general clinical use. At this time in the United States,...References1. TANNENBAUM G and LING N. The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion. Endocrinology. 1984;115:1952-7. CrossrefMedlineGoogle Scholar2. VANCE M, KAISER D, RIVIER J, VALE W, and THORNER M. Dual effects of growth hormone (GH)-releasing hormone infusion in normal men: somatotroph desensitization and increase in releasable GH. J Clin Endocrinol Metab. 1986;62:591-4. CrossrefMedlineGoogle Scholar3. THORNER M, VANCE M, and EVANS W. Physiological and clinical studies of GRF and GH. Recent Prog Horm Res. 1986;42:589-640. MedlineGoogle Scholar4. PENNY E, PENMAN E, and PRICE J. Circulating growth hormone releasing factor concentrations in normal subjects and patients with acromegaly. Br Med J [Clin Res]. 1984;289:453-5. CrossrefMedlineGoogle Scholar5. SAITO H, SAITO S, YAMAZAKI R, and HOSOI E. Clinical value of radioimmunoassay of plasma growth-hormone-releasing factor [Letter]. Lancet. 1984;2:401-2. CrossrefMedlineGoogle Scholar6. THORNER M, FROHMAN L, and LEONG D. Extrahypothalamic growth-hormone-releasing factor (GRF) secretion is a rare cause of acromegaly: plasma GRF levels in 177 acromegalic patients. J Clin Endocrinol Metab. 1985;59:846-9. CrossrefGoogle Scholar7. CHIHARA K, KASHIO Y, and KITA Y. L-Dopa stimulates release of hypothalamic growth hormone-releasing hormone in humans. J Clin Endocrinol Metab. 1986;62:466-73. CrossrefMedlineGoogle Scholar8. EVANS W, VANCE M, and KAISER D. Effects of intravenous, subcutaneous, and intranasal administration of human growth hormone (GH)-releasing hormone-40 on serum GH concentrations in normal men. J Clin Endocrinol Metab. 1985;61:846-50. CrossrefMedlineGoogle Scholar9. VANCE M, BORGES J, and KAISER D. Human pancreatic tumor growth hormone-releasing factor: dose-response relationships in normal man. J Clin Endocrinol Metab. 1984;58:838-44. CrossrefMedlineGoogle Scholar10. EVANS W, BORGES J, and VANCE M. Effects of human pancreatic growth-hormone-releasing factor-40 on serum growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone and somatomedin-C concentrations in normal women throughout the menstrual cycle. J Clin Endocrinol Metab. 1984;59:1006-10. CrossrefMedlineGoogle Scholar11. GELATO M, PESCOVITZ O, CASSORLA F, LORIAUX D, and MERRIAM G. Dose-response relationships for the effects of growth hormone-releasing factor-(1-44)-NH2 in young adult men and women. J Clin Endocrinol Metab. 1984;59:197-201. CrossrefMedlineGoogle Scholar12. BORGES J, BLIZZARD R, and GELATO M. Effects of human pancreatic tumour growth hormone releasing factor on growth hormone and somatomedin C levels in patients with idiopathic growth hormone deficiency. Lancet. 1983;2:119-24. CrossrefMedlineGoogle Scholar13. ROGOL A, BLIZZARD R, and JOHANSON A. Growth hormone release in response to human pancreatic tumor growth hormone-releasing hormone-40 in children with short stature. J Clin Endocrinol Metab. 1984;59:580-6. CrossrefMedlineGoogle Scholar14. TAKANO K, HIZUKA N, and SHIZUME K. Plasma growth hormone (GH) response to GH-releasing factor in normal children with short stature and patients with pituitary dwarfism. J Clin Endocrinol Metab. 1984;58:236-41. CrossrefMedlineGoogle Scholar15. ROSENTHAL S, SCHRIOCK E, KAPLAN S, GUILLEMIN R, and GRUMBACH M. Synthetic human pancreas growth hormone-releasing factor (hpGRFl-44-NH2) stimulates growth hormone secretion in normal men. J Clin Endocrinol Metab. 1983;57:677-9. CrossrefMedlineGoogle Scholar16. SCHRIOCK E, LUGTIG R, ROSENTHAL S, KAPLAN S, and GRUMBACH M. Effect of growth hormone (GH)-releasing hormone (GRH) on plasma GH in relation to magnitude and duration of GH deficiency in 26 children and adults with isolated GH deficiency or multiple pituitary hormone deficiencies: evidence for hypothalamic GRH deficiency. J Clin Endocrinol Metab. 1984;58:1043-9. CrossrefMedlineGoogle Scholar17. GROSSMAN A, LYTRAS N, and SAVAGE M. Growth hormone releasing factor: comparison of two analogues and demonstration of hypothalamic defect in growth hormone release after radiotherapy. Br Med J [Clin Res]. 1984;288:1785-7. CrossrefMedlineGoogle Scholar18. VANCE M, EVANS W, and KAISER D. The effect of intravenous, subcutaneous, and intranasal GHRH analog, Nle27GHRH-29NH2, on growth hormone secretion in normal man: dose response relationships. Clin Pharmacol Ther. 1986. (In press). CrossrefMedlineGoogle Scholar19. WOOD S, CH'NG J, and ADAMS E. Abnormalities of growth hormone release in response to human pancreatic growth hormone releasing factor (GRF (1-44)) in acromegaly and hypopituitarism. Br Med J [Clin Res]. 1983;286:1687-91. CrossrefMedlineGoogle Scholar20. SHIBASAKI T, SHIZUME K, and MASUDA A. Plasma growth hormone response to growth hormone-releasing factor in acromegalic patients. J Clin Endocrinol Metab. 1984;58:215-7. CrossrefMedlineGoogle Scholar21. GELATO M, MERRIAM G, and VANCE M. Effects of growth hormone-releasing factor on growth hormone secretion in acromegaly. J Clin Endocrinol Metab. 1985;60:251-7. CrossrefMedlineGoogle Scholar22. BELCHETZ P, PLANT T, NAKAI Y, KEOGH E, and KNOBIL E. Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone. Science. 1978;202:631-3. CrossrefMedlineGoogle Scholar23. MANSFIELD M, BEARDSWORTH D, and LOUGHLIN J. Long-term treatment of central precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone: effects on sematic growth and skeletal maturation. N Engl J Med. 1983;309:1286-90. CrossrefMedlineGoogle Scholar24. . Leuprolide versus diethylstilbestrol for metastatic prostate cancer. N Engl J Med. 1984;311:1281-6. CrossrefMedlineGoogle Scholar25. HURLEY D, BRIAN R, and OUTCH K. Induction of ovulation and fertility in amenorrheic women by pulsatile low-dose gonadotropin-releasing hormone. N Engl J Med. 1984;310:1069-74. CrossrefMedlineGoogle Scholar26. WAGNER T, BRABANT G, WARSCH F, HESCH R, and VON ZUR MUHLEN A. Pulsatile gonadotropin-releasing hormone treatment in idiopathic delayed puberty. J Clin Endocrinol Metab. 1986;62:95-101. CrossrefMedlineGoogle Scholar27. THORNER M, PERRYMAN R, and CRONIN M. Somatotroph hyperplasia: successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest. 1982;70:965-77. CrossrefMedlineGoogle Scholar28. VANCE M, KAISER D, and EVANS W. Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of growth hormone releasing factor (1-40): evidence for intermittent somatostatin secretion. J Clin Invest. 1985;75:1584-90. CrossrefMedlineGoogle Scholar29. VANCE M, KAISER D, and EVANS W. Evidence for a limited growth hormone (GH)-releasing hormone (GHRH)-releasable quantity of GH: effects of 6-hour infusions of GHRH on GH secretion in normal man. J Clin Endocrinol Metab. 1985;60:370-5. CrossrefMedlineGoogle Scholar30. VANCE M, EVANS W, and THORNER M. Growth hormone secretion is augmented during 14 days of continuous growth hormone releasing hormone in normal man [Abstract]. Clin Res. 1986;34:435A. Google Scholar31. THORNER M, RESCHKE J, and CHITWOOD J. Acceleration of growth in two children treated with human growth hormone-releasing factor. N Engl J Med. 1985;312:4-9. CrossrefMedlineGoogle Scholar32. THORNER M, BLIZZARD R, and MARTHA P. Potential role of GRF for growth hormone deficiency [Abstract]. In: Proceedings of the 68th Annual Meeting of the Endocrine Society. Anaheim, California: The Endocrine Society; 1986:28. Google Scholar33. Ross R, RODDA C, and DAVIES P. Growth hormone-releasing hormone treatment of growth hormone deficient children [Abstract]. Clin Res. 1986;34:726A. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARY LEE VANCE, M.D.; MICHAEL O. THORNER, M.B., F.R.C.P. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDictionary of Inorganic CompoundsGrowth hormone – releasing hormone : a clinical perspective 1 September 1986Volume 105, Issue 3Page: 447-449KeywordsGrowth hormoneHormonesSpecificity ePublished: 1 December 2008 Issue Published: 1 September 1986 PDF downloadLoading ...