Pulmonary Effects of Carmustine (Bischloroethylnitrosourea, BCNU)
Authors: ROBIN L. KAPLAN
Journal: Annals of Internal Medicine (1979)

Letters and Correction1 July 1979Pulmonary Effects of Carmustine (Bischloroethylnitrosourea, BCNU)ROBIN L. KAPLAN, M.D.ROBIN L. KAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-131_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report by Durant and colleagues in the February issue (1) is interesting, but, with one exception, their patients are not convincing examples of persons who have developed pulmonary toxicity secondary to carmustine (bischloroethylnitrosourea, BCNU). Nine of the 10 patients were receiving one or more drugs known to produce hypersensitivity reactions or fibrosis simultaneously with carmustine. Only the patient with glioblastoma received no prior or concurrent chemotherapy. In addition, five of the 10 patients (including the patient with glioblastoma) had received prior radiation therapy. However scrupulously the lungs had been shielded, it is difficult to completely exclude...Reference1. DURANT J, NORGARD M, MURAD T, BARTOLUCCI A, and LANGFORD K. Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU). Ann Intern Med. 1979;90:191-4. LinkGoogle Scholar1. HOLOYE P, JENKINS D, and GREENBERG S. Pulmonary toxicity in long-term administration of BCNU. Cancer Treat Rep. 1976;60:1691-4. MedlineGoogle Scholar2. WEISS R, SHAH S, and SHANE S. Pulmonary toxicity from carmustine (BCNU). Med Pediatr Oncol. 1979;6. In press. CrossrefMedlineGoogle Scholar3. DURANT J, NORGARD M, MURAD T, BARTOLUCCI A, and LANGFORD K. Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU). Ann Intern Med. 1979;90:191-4. LinkGoogle Scholar4. PATEL A, SHAH P, RHEE H, SASSOON H, and ROO K. Cyclophosphamide therapy and interstitial pulmonary fibrosis. Cancer. 1976;38:1542-9. CrossrefMedlineGoogle Scholar5. LEE W, MOORE R, and WAMPLER G. Interstitial pulmonary fibrosis as a complication of prolonged methyl-CCNU therapy. Cancer Treat Rep. 1978;62:1355-8. MedlineGoogle Scholar1. DURANT J, NORGARD M, MURAD T, BARTOLUCCI A, and LANGFORD K. Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU). Ann Intern Med. 1979;90:191-4. LinkGoogle Scholar2. GREEN M. Pulmonary toxicity of antineoplastic agents. West J Med. 1977;127:292-8. MedlineGoogle Scholar3. LIPPMANN M. Pulmonary reaction to drugs. Med Clin North Am. 1977;61:1353-67. CrossrefMedlineGoogle Scholar4. SOSTMAN H, MATTHAY R, and PUTNAM C. Cytotoxic drug-induced lung disease. Am J Med. 1977;62:608-15. CrossrefMedlineGoogle Scholar5. CROOKE S and BRADNER W. Bleomycin, a review. J Med. 1976;7:333-428. MedlineGoogle Scholar1. DURANT J, NORGARD M, MURAD T, BARTOLUCCI A, and LANGFORD K. Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU). Ann Intern Med. 1979;90:191-4. LinkGoogle Scholar1. SELKER R, JACOBS S, and MOORE P. Interstitial pulmonary fibrosis as a complication of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy. Proc Am Assoc Cancer Res. 1978;19:333. Abstract. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBIN L. KAPLAN, M.D.Affiliations: University of Colorado Medical Center Denver, CO 80262 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIatrogenia a fármacos no contexto do Aparelho RespiratórioCYCLOPHOSPHAMIDE: PULMONARY METABOLISM, TOXICITY AND PROTECTIVE EFFECT OF VITAMIN EPulmonary Effects of Cytotoxic Agents Other Than BleomycinMetabolism and pulmonary toxicity of cyclophosphamideDrug-induced pulmonary diseasePulmonary toxicity of antitumor agentsThe nitrosoureas and pulmonary toxicityCytotoxic drug-induced pulmonary disease: Update 1980 1 July 1979Volume 91, Issue 1 Page: 131-133 Keywords Chemotherapy Drugs Fibrosis Glioblastoma multiforme Hypersensitivity Lungs Radiation therapy Toxicity ePublished: 1 December 2008 Issue Published: 1 July 1979 PDF downloadLoading ...