tbuckley/cabot-search huggingface dataset:
Hyperactivity of fibroblasts cultured from psoriatic skin: I. Faster proliferation and effect of serum withdrawal
Authors: G.C. PRIESTLEY, L.W. ADAMS
Journal: British Journal of Dermatology (1983)

Fibroblasts were cultured from the involved and uninvolved forearm skin of patients with severe generalized psoriasis and compared with those from the forearms of normal controls of similar ages. Thirteen strains were obtained from involved skin (PSA strains) and sixteen strains from uninvolved skin (PSB), with thirteen control strains (NSF). Outgrowth of fibroblasts from the psoriatic skin explants was slightly quicker than from control skin and the average proliferation rates of passaged strains were PSA 144, PSB 134 and NSF 94 (P less than 0.05). Psoriatic fibroblasts were abnormally dependent on serum for anchorage. In serum-free medium many cells rounded up and were only loosely attached to the substratum. This effect was rapid, reversible and not corrected by adding fibronectin. Cell attachment assays showed only small differences between the psoriatic and normal fibroblasts and the main effect of serum withdrawal appeared to be on spreading rather than attachment. These data suggest that the dermis of both involved and uninvolved psoriatic skin is abnormal and that the hyperactivity persists in vitro. Our findings seem most compatible with a hyperproliferative reaction of both epidermis and dermis to an extracutaneous, perhaps vascular, stimulus.
Global Report Highlights Tobacco Use, Offers Countermeasures for Nations
Authors: Tracy Hampton
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lambert-Eaton myasthenic syndrome and undifferentiated connective tissue disease in a patient carrying the 8.1 ancestral haplotype
Authors: M A Kriegel
Journal: Annals of the Rheumatic Diseases (2004)

No patient had a history of a male twin or a solid organ transplant at the time of biopsy.SLE, systemic lupus erythematosus; CLE, cutaneous lupus erythematosus; DM, dermatomyositis; MF, mycosis fungoides.
Criticism of prophylaxis of gastrointestinal bleeding with H2 receptor antagonists is wrong
Authors: T M Cook
Journal: BMJ (1997)

Superficial analysis ignores evidence on efficacy of treatmentEditor-The conclusions of John Wright and colleagues have the potential to jeopardise public health as well as patients' care; their systematic review lacks the necessary depth and understanding of the issues. 1he authors note that sleep apnoea is currently viewed as a public health concern because it is prevalent and thought to be associated with morbidity and mortality.The collective evidence from the studies included in the review supports this view; the authors' conclusions that evidence for the health effects of sleep apnoea is "weak or contradictory" and that "the relevance of sleep apnoea to public health has been exaggerated" are disturbing.The authors seem to have misinterpreted the findings of some studies.In their assessment of nine studies of hypertension judged to be methodologically adequate, the authors dismiss seven studies that show an independent association between sleep apnoea and hypertension.
Functional Imaging in Phase I Studies: Decorations or Decision Making?
Authors: Jerry M. Collins
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.05.100 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12807933 Functional Imaging in Phase I Studies: Decorations or Decision Making? Jerry M. CollinsxJerry M. CollinsSearch for articles by this author Show More Laboratory of Clinical Pharmacology, United States Food and Drug Administration, Rockville, MD https://doi.org/10.1200/JCO.2003.05.100 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Tamoxifen for Breast Cancer
Authors: SEWA S. LEGHA
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 April 1978Tamoxifen for Breast CancerSEWA S. LEGHA, M.D., F.A.C.P.SEWA S. LEGHA, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-574_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Kiang and Kennedy (Ann Intern Med87:687-690, 1977) adds to the growing literature on the effectiveness and relative lack of toxicity from tamoxifen (1-3). Evidence is now sufficient to claim that antitumor activity of tamoxifen in metastatic breast cancer in postmenopausal women is at least equal to that of conventionally used estrogens. Because of its excellent patient tolerance, tamoxifen's use is justified in preference to diethylstilbestrol as the primary therapy of recurrent breast cancer in postmenopausal patients. Further, Kiang and Kennedy's paper corroborates previous reports with other antiestrogens such as nafoxidine (4) that...References1. COLEJONESTODD MTI: A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474. Br J Cancer 25:270-275, 1971 CrossrefMedlineGoogle Scholar2. WARD H: Anti-oestrogen therapy for breast cancer: a trial of tamoxifen at two dose levels. Er Med J 1:13-14, 1973 CrossrefMedlineGoogle Scholar3. MORGANSCHEINWOLLEYHOTHMACDONALDLIPPMANPOSEYBEARLEY LPPDTMLR: Therapeutic use of tamoxifen in advanced breast cancer: correlation with biochemical parameters. Cancer Treat Rep 60:1437-1443, 1976 MedlineGoogle Scholar4. BLOOMBOESEN HE: Anti-oestrogens in treatment of breast cancer: value of nafoxidine in 52 advanced cases. Br Med J 2:7-10, 1974 CrossrefMedlineGoogle Scholar1. MORGANSCHEINWOLLEYHOTHMACDONALDLIPPMANPOSEYBEARLEY LPPDTMLR: Therapeutic uses of tamoxifen in advanced breast cancer: correlation with biochemical parameters. Cancer Treat Rep 60:1437-1443, 1976 MedlineGoogle Scholar2. KIANGKENNEDY DB: Factors affecting estrogen receptors in breast cancer. Cancer 40:1571-1576, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: M. D. Anderson Hospital and Tumor Institute Houston, TX 77030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCharacterization of estrogen-receptor-targeted contrast agents in solution, breast cancer cells, and tumors in vivoRandomized Clinical Trial of Diethylstilbestrol versus Tamoxifen in Postmenopausal Women with Advanced Breast Cancer 1 April 1978Volume 88, Issue 4Page: 574-574KeywordsBreast cancerEstrogensToxicity Issue Published: 1 April 1978 PDF DownloadLoading ...
Yes to careful introduction of robot assisted surgery
Authors: A. McNeill, G. D. Stewart
Journal: BMJ (2011)

From the perspective of Scotland’s only high volume laparoscopic prostatectomy centre we agree that “even the staunchest laparoscopic urologists would like to use a robot.”1 Although outcomes from high volume surgeons are comparable regardless of the surgical technique used for radical prostatectomy, a randomised trial comparing techniques will now be …
Avoiding the Slippery Knot Syndrome
Authors: Jack H. Bloch
Journal: JAMA (1976)

To the Editor.—  The problem of coated and impregnated monofilament suture material becoming untied is not a new one; it has been experienced by the undersigned on two occasions.  Since these two misadventures, we have been tying three knots, the last two of which are square, and applying a 3-mm Weck clipped firmly across the ends of the suture adjacent to the knot. The suture is then cut distal to the clip (Fig 2).  An alternative method of keeping the knot from becoming untied is to coagulate the suture above the knot with an electrasurgical unit.  There are no instances of the knot slipping or coming untied since we have adopted these practices.
Letter: Rubella in pregnancy: a difficult diagnosis.
Authors: J R Sutherst, M Burke
Journal: BMJ (1975)

2 80-9 20)* (0 80-5 05)* (1-15-3 85)* Nairobi, 12 Blood Kasili et al.' donors 5 00 2-11 2 43 0 33 (152) (2-00-10-70)t (0 36-5-62)t (0-81-5 45)t (0-2 11)t _ Lusaka, Blood Ezeilo3 donors
The Question of Hypertension
Authors: GEORGE A. PERERA
Journal: Annals of Internal Medicine (1961)

Editorials1 July 1961The Question of HypertensionGEORGE A. PERERA, M.D., F.A.C.P.GEORGE A. PERERA, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-1-169 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn this issue of the Annals are found three provocative papers dealing with essential hypertension. Each contributor raises a different question; each answer is itself subject to question. Perhaps more than anything else, these manuscripts serve to illustrate that it is a legitimate function to arouse curiosity, although not always to satisfy it.Sir Robert Platt provokes us in a most interesting fashion with his "tentative" conclusion that essential hypertension is a hereditary disorder. But has he distinguished genetic inheritance clearly from what may be merely a familial concentration? This is a vital point. The appropriateness of a continuing search... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Presbyterian Hospital 620 West 168th Street New York 32, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe epidemiology of essential hypertension 1 July 1961Volume 55, Issue 1Page: 169-169KeywordsAttentionGeneticsHypertension Issue Published: 1 July 1961 PDF DownloadLoading ...
TCT-685 High Procedure Success Rate in Device Closure of Atrial Septal Defect with Multiple Rim Deficiencies
Authors: Yasufumi Kijima, Teiji Akagi, Koji Nakagawa, Norihisa Toh, Manabu Taniguchi, Shunji Sano, Ito Hiroshi
Journal: Journal of the American College of Cardiology (2013)
SHO training: Proposals expensive
Authors: A. Bamji
Journal: BMJ (1993)

We hope that this extension ofour assessment of the senior house officers in our department proves to be both useful and acceptable to them.The main drawback to this form of assessment is that it is labour intensive, requiring the synchronous participation of both the junior and senior doctors of the department.This programme of assessment is being extended to include other hospitals in our region.Towards the end of this year we hope to report our experiences after assessing the training of further groups of senior house officers working in our department.
Biomaterials for Bone Regenerative Engineering
Authors: Xiaohua Yu, Xiaoyan Tang, Shalini V. Gohil, Cato T. Laurencin
Journal: Advanced Healthcare Materials (2015)

Strategies for bone tissue regeneration have been continuously evolving for the last 25 years since the introduction of the "tissue engineering" concept. The convergence of the life, physical, and engineering sciences has brought in several advanced technologies available to tissue engineers and scientists. This resulted in the creation of a new multidisciplinary field termed as "regenerative engineering". In this article, the role of biomaterials in bone regenerative engineering is systematically reviewed to elucidate the new design criteria for the next generation of biomaterials for bone regenerative engineering. The exemplary design of biomaterials harnessing various materials characteristics towards successful bone defect repair and regeneration is highlighted. Particular attention is given to the attempts of incorporating advanced materials science, stem cell technologies, and developmental biology into biomaterials design to engineer and develop the next generation bone grafts.
Nested case-control studies
Authors: P. Sedgwick
Journal: BMJ (2010)

The association between suicide and the use of calcium channel blockers in people with hypertension was investigated using a nested case-control study design.1 Data were taken from the general practice research database, a computerised database of anonymised longitudinal medical records collected prospectively in primary care. The cohort of people with records between January 1991 and August 1998 was used.

At the end of data collection, 38 people who had committed suicide had received a prescription for an antihypertensive drug within six months of their death. One hundred and forty controls—matched for age, sex, general practice, and index date—were selected from the same cohort. …
Characterisation of the effector cells responsible for the in vitro cytotoxicity of blood leucocytes from aphthous ulcer patients for oral epithelial cells.
Authors: D W Thomas, J Bagg, D M Walker
Journal: Gut (1990)

This study was designed to identify the cells responsible for the spontaneous cell mediated cytotoxic effect (SCMC) exerted by peripheral blood leucocytes from patients with recurrent aphthous ulceration, towards cultured oral epithelial cells. Peripheral blood leucocytes from recurrent aphthous ulceration patients exerted a significantly greater (p less than 0.01) degree of cytotoxicity towards the oral epithelial target cells than did peripheral blood leucocytes from healthy control subjects, or from patients with non-specific ulceration. Depletion of CD-5 positive cells (T-lymphocytes) resulted in a significant decrease in the SCMC in aphthous patients. Depletion of CD-16 positive cells (NK-cells) produced no significant change in cytotoxicity. T-lymphocytes, therefore, appear to be intimately involved in the in vitro SCMC effect in recurrent aphthous ulceration.
Asphyxia Due to an Inhaled Foreign Body
Authors: Neda Zarrin-Khameh, Robert E Lyon
Journal: New England Journal of Medicine (2005)

A three-year-old boy was playing with a small plastic ball while riding in the backseat of a motor vehicle driven by his father. The father heard a gasp, saw that the child was unconscious, and pulled to the side of the road. He suspected the child had aspirated the toy ball and tried to dislodge it by patting the child on the back. Emergency personnel intubated the child at the scene. No foreign body was visualized during the intubation. The child was dead on arrival at the emergency center. During the postmortem examination, a radiograph of the head and neck . . .
β2-MICROGLOBULIN AND HAEMODIALYSIS
Authors: S. Shaldon, K.M. Koch, C.A. Dinarello, C.K. Colton, P.J. Knudsen, J. Floege, C. Granolleras, J. Bonal, M.C. Pastor, R. Romero, A. Corominas, A. Caralps, G. Mayer, J. Thum, W. Woloszczuk, H. Graf
Journal: The Lancet (1987)
Perforation of a Typhoid Ulcer: Operation: Recovery
Authors: H. Handford, A. R. Anderson
Journal: BMJ (1898)

Lastly, it will be the function of such an organisation to insist that special asylums for admittedly dying cases of tuberculosis among the poorer classes should be erected by the local authorities, in the interests both of the dying and the living, and that wisely-colnceived preventive measures be adopted by every community.
Spatial Distribution of Connexin43, the Major Cardiac Gap Junction Protein, Visualizes the Cellular Network for Impulse Propagation From Sinoatrial Node to Atrium
Authors: I. ten Velde, B. de Jonge, E.E. Verheijck, M.J.A. van Kempen, L. Analbers, D. Gros, H.J. Jongsma
Journal: Circulation Research (1995)

Abstract Myocytes are electrically coupled by gap junctions, which are composed of low-resistance intercellular channels. The major cardiac gap junction protein is connexin43 (Cx43). The distribution of Cx43 has been studied by immunofluorescence to visualize the electrical coupling between atrial tissue and sinoatrial node. From modeling studies, this coupling was inferred to be gradual in order to shield the sinoatrial node from the atrial hyperpolarizing influence. The actual Cx43 labeling pattern did not show the expected gradient but instead a rather black and white staining in a striking pattern of strands of cells. We used an immunohistochemical marker (anti–α-smooth muscle actin [αSMA]) that specifically cross-reacts with guinea pig sinoatrial node cells together with Cx43 antibody to stain previously electrophysiologically mapped sinoatrial nodes. We found that in the guinea pig sinoatrial node the impulse originates in an αSMA-positive, virtually Cx43-negative, region (primary pacemaker region). The impulse then travels obliquely upward to the crista terminalis through a region where layers of αSMA-positive cells alternate with layers of Cx43-positive SMA-negative cells. The layers of Cx43-positive cells appear to become broader and thicker in the direction of the crista terminalis, whereas the layers of αSMA-positive cells become thinner and narrower. Lateral contacts between Cx43- and αSMA-positive cells were very sparse and only detected where the Cx43-positive strands ended (the region where αSMA-positive cells fill the whole space between endocardium and epicardium, ie, the putative primary pacemaker region). From these results, we conclude that the primary pacemaker is shielded from the hyperpolarizing influence of the atrium by a gradient in coupling brought about by tissue geometric factors rather than by a gradient of gap junction density.
Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine
Authors: Edward D. Freis
Journal: New England Journal of Medicine (1954)

THE introduction of Rauwolfia serpentina into this country by Wilkins and Judson1 and the purification of an active alkaloid, reserpine (Serpasil), has led to the widespread clinical use of the latter drug not only in hypertension2 , 3 but also in neuropsychiatric conditions.4 The purpose of this report is to describe the development of psychiatric complications in hypertensive patients treated with large doses of reserpine for long periods.Case ReportsCase 1. Mrs. I.K., a 54-year-old widow, had mild hypertension for 1 year associated with headache and substernal pain. Since the death of her husband 2 years previously she had been more . . .
Abstract P2-06-22: The Modulation of CXCL9 Release by Prostaglandin E2 and Cyclooxygenase Inhibitors in Human Breast Cancer
Authors: H Bronger, S Kräft, A Stöckel, A Welk, M Kiechle, M Schmitt, U. Schwarz-Boeger
Journal: Cancer Research (2010)

Abstract Introduction IFN γ inducible chemokine CXCL9 impairs tumor growth and metastasis formation through recruitment of natural killer (NK) cells and tumor suppressive T lymphocytes in murine breast cancer models. In human breast cancer CXCL9 mRNA expression correlates with response to different chemotherapeutic regimens and tumor infiltrating lymphocytes, indicating that enhancing intratumoral CXCL9 is a feasible therapeutic way to improve tumor suppressive immune infiltration. However, little is known about the regulation of CXCL9 in human breast cancer. Since overexpression of cyclooxygenases (COX) correlates with impaired NK cell infiltration as shown before, this system is a conceivable candidate for modulating intratumoral CXCL9 concentration. Material and Methods For regulation studies, MCF 7 and MDA MB 231 breast cancer cells were stimulated with IFN γ with or without prostaglandin E2 (PGE2) or COX inhibitors (indomethacin, aspirin, celecoxib). CXCL9 was localized in human breast cancer samples by immunohistochemistry. Its release was measured by ELISA. Expression of CXCL9 and cyclooxygenases in 60 breast cancer samples was determined by ELISA and western blot, respectively. Results Within the tumor microenvironment, the cancer cells are the major source of CXCL9, thus making them the appropriate cell type to study CXCL9 regulation. PGE2 significantly reduces IFN γ mediated CXCL9 release from MCF 7 and MDA MB 231 cells, and inhibition of endogenous cyclooxygenases by indomethacin or aspirin correspondingly augments this secretion. However, the COX 2 specific antagonist celecoxib has PGE2-agonistic effects and impairs CXCL9 release, probably via COX independent mechanisms. Conclusion Suppressing endogenous PGE2 by cyclooxygenase inhibition increases CXCL9 release from breast cancer cells and is therefore a feasible way to enhance intratumoral immune infiltration. However, due to possible COX independent mechanisms the choice of the appropriate COX inhibitor seems to be crucial. The predictive value of CXCL9 as a novel biomarker and its correlation with COX overexpression in human breast cancer is discussed. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-06-22.
Evidence for a relationship between oxidative stress and insulin action in non-insulin-dependent (type II) diabetic patients
Authors: Giuseppe Paolisso, Anna D'Amore, Clelia Volpe, Vinicio Balbi, Franco Saccomanno, Domenico Galzerano, Dario Giugliano, Michele Varricchio, Felice D'Onofrio
Journal: Metabolism (1994)
Congenital Afibrinogenemia
Authors: Herman A. Lawson
Journal: New England Journal of Medicine (1953)

CONGENITAL afibrinogenemia is a rare disease that was first described by Rabe and Salomon1 in 1920. Since that time about a dozen cases have been reported in the medical literature. A recent report from Ceylon2 described the occurrence of this disorder in a child of mixed English and Eurasian parentage. Probably other cases have been encountered, although not recorded in the medical literature. Henderson, Donaldson and Scarborough3 have presented a case and given an excellent review. The most interesting feature of the case discussed below is the fact that the patient, a girl in her twentieth year, seems in excellent . . .
Mesalazine-induced bronchiectasis and eosinophilia in a patient with ulcerative colitis: a case report
Authors: L C Price, A Poullis, S Grubnic, J Y Kang, C F J Rayner
Journal: Journal of the Royal Society of Medicine (2007)

We describe a case of mesalazine-induced eosinophilia and bronchiectasis in a patient with ulcerative colitis, and discuss the diagnostic challenges involved.