Pure Nephrosis in an Adult Patient
Authors: HIROSHI YAMAUCHI
Journal: Annals of Internal Medicine (1961)

Case Reports1 September 1961Pure Nephrosis in an Adult PatientSerial Observations of Blood Volume, Serum Electrolytes, and Renal FunctionHIROSHI YAMAUCHI, JAMES HOPPER JR., M.D.HIROSHI YAMAUCHISearch for more papers by this author, JAMES HOPPER JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-3-464 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA young woman with the characteristic features of pure nephrosis was successfully treated with steroids at H. C. Moffitt Hospital. The clinical course and results of serial determinations of blood volume, creatinine clearance, serum proteins, and electrolytes before, during, and after treatment are described in this report.This case is of particular interest (1) because of an episode of shock attributable in part to a diminished blood volume and in part to the administration of medication with antihypertensive properties; (2) because of the dramatic response to adrenal steroid therapy, accompanied by rapid disappearance of proteinuria and spectacular recovery of serum...References1. NOMOFHOPPERBROWNSCOTTWENNESLAND NJEKR: Simultaneous determinations of the total volume of red blood cells by use of carbon monoxide and chromium51 in healthy and diseased human subjects. J. Clin. Invest. 33: 1382, 1954. CrossrefMedlineGoogle Scholar2. WENNESLANDBROWNHOPPERHODGESGUTTENTAGSCOTTTUCKERBRADLEY REJJLOEKGINB: Red cell, plasma and blood volume in healthy men measured by radiochromium (Cr51) cell tagging and hematocrit: influence of age, somatotype and habits of physical activity on the variance after regression of volumes to height and weight combined. J. Clin. Invest. 38: 1065, 1959. CrossrefMedlineGoogle Scholar3. ALBRINKHALDMANPETERS MJPMEBJP: The displacement of serum water by the lipids of hyperlipemic serum. A new method for the rapid determination of serum water. J. Clin. Invest. 34: 1483, 1955. CrossrefMedlineGoogle Scholar4. HOPPERFARQUHARYAMAUCHIMOONPAGE JMGHHDEW: Renal lesions in pregnancy: clinical observations and light and electron microscopic findings. Obstet. Gynec. (N. Y.) 17: 271, 1961. Google Scholar5. FARQUHAR M: Review of normal and pathologic glomerular ultrastructure, in Proceedings of the Tenth Annual Conference on the Nephrotic Syndrome, ed. by Metcoff, J., The National Kidney Disease Foundation, New York, 1959, p. 2. Google Scholar6. KARKPIRANIPOLLAKMUEHRCKEBLAINEY RMCLVERCJD: The nephrotic syndrome in adults: a common disorder with many causes. Ann. Intern. Med. 49: 751, 1958. LinkGoogle Scholar7. WEECH AA: The significance of the albumin fraction of serum. Harvey Lecture. Bull. N. Y. Acad. Med. 15: 63, 1939. MedlineGoogle Scholar8. WIGGERS CJ: Physiology in Health and Disease, 5th Ed., Lea & Febiger, Philadelphia, 1949, p. 358. Google Scholar9. YAMAUCHIHOPPER HJ: Hypovolemic shock and hypotension in the nephrotic syndrome. Clin. Res. Proc. 7: 125. 1959. Google Scholar10. YAMAUCHIHOPPERMCCORMACK HJK: Blood volume and fainting in nephrosis. Clin. Res. 8: 195, 1960. Google Scholar11. EMERSONDOLE KJVP: Diodrast and inulin clearances in nephrotic children with supernormal urea clearances. J. Clin. Invest 22: 447, 1943. CrossrefMedlineGoogle Scholar12. BRUCKRAPOPORTRUBIN EMMI: Renal functions in the course of the nephrotic syndrome in children. J. Clin. Invest. 33: 699 1954. CrossrefMedlineGoogle Scholar13. HOPPERYAMAUCHI JH: Unpublished observations. Google Scholar14. FRIEND DG: Current concepts in therapy. Tranquilizers. II. The phenothiazines. 1. New Engl. J. Med. 260: 1028, 1959. MedlineGoogle Scholar15. YAMAUCHIHOPPERMCCORMACKLAMBERT HJKK: Hypovolemia in the nephrotic syndrome—a contraindication to renal biopsy. New Engl. J. Med. 263: 1012, 1960. CrossrefMedlineGoogle Scholar16. EDELMANLEIBMANO'MEARABIRKENFELD ISJMPLW: Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water. J. Clin. Invest. 37: 1236, 1958. CrossrefMedlineGoogle Scholar17. LUETSCHER JA: Problems of electrolyte and water balance in nephrotic syndrome. Arch. Intern. Med. 95: 380, 1955. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HIROSHI YAMAUCHI; JAMES HOPPERJR., M.D.Affiliations: San Francisco, CaliforniaReceived for publication July 5, 1960.From the Department of Medicine, University of California School of Medicine, San Francisco, Calif.This study was supported by Grant H-1271 from the United States Public Health Service and by funds allocated by the Committee on Research, University of California School of Medicine.Opinions expressed are solely those of the authors and in no way reflect the official views of the United States Air Force.Requests for reprints should be addressed to Editorial Office, Department of Medicine, University of California Medical Center, San Francisco 22, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byControl of Aldosterone SecretionHypovolemic Shock and Hypotension as a Complication in the Nephrotic Syndrome Report of Ten CasesHIROSHI YAMAUCHI, M.D., JAMES HOPPER JR., M.D.Nephrotic State as the Chief Manifestation of Systemic Lupus ErythematosusHIROSHI YAMAUCHI, PIERCE ROONEY, M.D., JAMES HOPPER JR., M.D. 1 September 1961Volume 55, Issue 3Page: 464-471KeywordsBlood volumeEdemaIngestionProteinuriaRenal circulationSaltsSerum proteinsShockSteroid therapySteroids ePublished: 1 December 2008 Issue Published: 1 September 1961 PDF downloadLoading ...