tbuckley/cabot-search huggingface dataset:
Ventilatory Cost of Exercise Before and After Mitral Valvotomy
Authors: J. P. P. Stock, M. C. S. Kennedy
Journal: Thorax (1959)

We have previously reported measurements of the maximum ventilatory capacity and the ventilatory requirements for a standard exercise in 26 patients with mitral stenosis (Stock and Kennedy, 1953).A small but variable reduction in maximum ventilatory capacity was noted which appeared to bear little relation to the severity of the patients' symptoms.On the other hand, it was found that increasing disability in mitral stenosis tended to be associated with an increasing ventilatory cost of exercise.We suggested that this increased ventilation might prove useful as an objective index of disability.In this communication, serial measurements of the ventilatory cost of exercise before and after operation in 85 patients with mitral stenosis treated surgically are presented, together with data from a further 20 patients whose symptoms did not warrant operation.In analysing the data, we have tried to assess the value of simple ventilatory tests as an objective index of disability and as a measure of operative success.In 40 cases the data obtained at cardiac catheterization have been related to the ventilatory findings.VENTILATORY FUNCTION TESTS The ventilatory cost of exercise has been measured using the Hugh-Jones exercise test (Hugh-Jones, 1952).In this test, after resting ventilation has been recorded, the patient steps on and off a platform, the height and rate of stepping being adjusted according to the patient's weight so that all subjects exercise at a work on July 26, 2023 by guest.
A case-control study on GB virus C/hepatitis G virus infection and hepatocellular carcinoma. Brescia HCC Study
Authors: A Tagger
Journal: Hepatology (1997)

A new hepatitis-associated RNA virus of the Flaviviridae family has been identified and named GB virus C/ hepatitis G virus (HGV). We carried out a case-control study to evaluate the association of HGV infection with hepatocellular carcinoma (HCC). We recruited 170 patients hospitalized for HCC (143 male and 27 female, mean age 64 years) and 306 patients hospitalized for nonliver diseases (controls) in Brescia, Italy. HGV RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) and antibodies against HGV E2 protein (anti-E2) by an immunoassay test. HGV RNA was found in 8 cases (4.7%) and 4 controls (1.3%). The relative risk (RR) for HGV RNA positivity adjusted for demographic variables and hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) RNA, and alcohol was 7.3 (95% confidence interval, 1.7-30.6; P = .009). No HGV RNA-positive subject was also positive for anti-E2. Anti-E2 prevalence did not differ significantly between cases (20%) and controls (15.3%), and no RR increase was found by this marker. Among subjects with HGV exposure (HGV RNA plus anti-E2 positive), a greater proportion of cases (40%) than controls (14%) had transfusion history. The possible role of HGV in HCC etiology seems modest because the population-attributable risk is lower (4%) than those for HBsAg (22%), HCV RNA (36%), and heavy alcohol intake (52%). This study supports the hypothesis of an association between HGV infection and HCC, although at present there are insufficient data on the causality of the association. (Hepatology 1997 Dec;26(6):1653-7)
Inhibition of neutrophil myeloperoxidase by rabbit anti-(human myeloperoxidase)
Authors: R A Thompson, S S Lee
Journal: Annals of the Rheumatic Diseases (1989)

settled and the biochemical abnormalities came back to normal, including parathyroid hormone of 0-48 ng/l.Our patient had dietary osteomalacia and secondary hyperparathyroidism which settled completely with cal- ciferol treatment.
Basal Cell Hyperplasia as a Surrogate Marker for Subepithelial Fibrosis in Pediatric Eosinophilic Esophagitis
Authors: K.M. Maples, J. Grubert, S. Poff, M. Aguiar, E. McGuire, S. Ebmeier, A. Fantaskey, S. Stanley, L. Willis
Journal: Journal of Allergy and Clinical Immunology (2011)
GBV-C Infection and Risk of NHL among U.S. Adults
Authors: Cindy M. Chang, Jack T. Stapleton, Donna Klinzman, James H. McLinden, Mark P. Purdue, Hormuzd A. Katki, Eric A. Engels
Journal: Cancer Research (2014)

Some retrospective studies suggest an association between infection with GB virus-C (GBV-C) and non-Hodgkin lymphoma (NHL). We evaluated this association prospectively in a nested case-control study within the U.S. Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Cases (N = 658) and controls (N = 1,316) were individually matched by age, sex, race/ethnicity, timing of study entry, and sample selection. Prediagnostic PLCO serum samples were tested for GBV-C RNA (as a measure of active infection) and E2 antibody (active or resolved infection). Logistic regression was used to estimate odds ratios (OR) for the association between GBV-C and NHL overall and NHL subtypes. Twelve cases (1.8%) and seven controls (0.5%) were GBV-C RNA-positive. GBV-C RNA positivity was associated with NHL overall [OR, 3.43; 95% confidence interval (CI), 1.35-8.71] and, based on small numbers, diffuse large B-cell lymphoma (OR, 5.31; 95% CI, 1.54-18.36). The association with NHL persisted when the interval between testing and selection was greater than 4 years (OR, 6.00; 95% CI, 1.21-29.73). In contrast, E2 antibody positivity was not associated with NHL risk (OR, 1.08; 95% CI, 0.74-1.58). Our study demonstrates that GBV-C infection precedes development of NHL. GBV-C infection may play an etiologic role in a small proportion of NHL cases, perhaps by causing chronic immune stimulation or impaired immunosurveillance.
Doctor gave "woeful" evidence
Authors: O. Dyer
Journal: BMJ (2003)

A pathologist delayed child abuse cases and misled courts by attributing injuries to a disease that almost nobody believes in, the General Medical Council heard last week.

Dr Colin Paterson blamed multiple fractures in children in Britain and the United States on temporary brittle bone disease (TBBD), a condition that he was the first to describe and whose existence is accepted by only a handful of experts.

The retired Scottish pathologist, formerly of Dundee University, is …
Dabigatran Compared With Warfarin for Stroke Prevention in Atrial Fibrillation
Authors: Alan M. Berg
Journal: Annals of Internal Medicine (2011)

Letters19 April 2011Dabigatran Compared With Warfarin for Stroke Prevention in Atrial FibrillationAlan M. Berg, MDAlan M. Berg, MDFrom Margolis Rheumatology Associates–University of Pittsburgh Medical Center, Pittsburgh, PA 15215.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-8-201104190-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent article on the cost-effectiveness of dabigatran versus warfarin, Freeman and colleagues (1) did not account for some of the highest costs associated with warfarin administration. Each time that prothrombin time is measured, the logistics involved cost money. Patients must travel to the laboratory to have blood drawn, or family members must take them. If patients are homebound, the cost of visiting nurses is high.The authors also did not account for the costs of prothrombin time measurement for physicians, patients, and caregivers. For example, when one of my patients undergoes measurement of prothrombin time, ...Reference1. Freeman JV, Zhu RP, Owens DK, Garber AM, Hutton DW, Go AS, et al. Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation. Ann Intern Med. 2011;154:1-11. [PMID: 21041570] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Alan M. Berg, MDAffiliations: From Margolis Rheumatology Associates–University of Pittsburgh Medical Center, Pittsburgh, PA 15215.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCost-Effectiveness of Dabigatran Compared With Warfarin for Stroke Prevention in Atrial Fibrillation James V. Freeman , Ruo P. Zhu , Douglas K. Owens , Alan M. Garber , David W. Hutton , Alan S. Go , Paul J. Wang , and Mintu P. Turakhia Dabigatran Compared With Warfarin for Stroke Prevention in Atrial Fibrillation David B. Edwards and John Silverberg Dabigatran Compared With Warfarin for Stroke Prevention in Atrial Fibrillation James V. Freeman and Mintu P. Turakhia Metrics Cited byThe caregiver role in thromboprophylaxis management in atrial fibrillation: A literature reviewEstimated medical cost reductions associated with apixaban in real-world patients with non-valvular atrial fibrillationMedical cost reductions associated with the usage of novel oral anticoagulants vs warfarin among atrial fibrillation patients, based on the RE-LY, ROCKET-AF, and ARISTOTLE trials 19 April 2011Volume 154, Issue 8Page: 570KeywordsCommunication in health careConflicts of interestDrug administrationDrugsGamesHealth careNursesProthrombin timeResearch laboratoriesStroke ePublished: 19 April 2011 Issue Published: 19 April 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Curiosity and Crisis
Authors: Thomas N. Wise
Journal: Psychotherapy and Psychosomatics (2006)

Editorials| June 19 2006 Curiosity and Crisis Subject Area: Psychiatry and Psychology Thomas N. Wise Thomas N. Wise Johns Hopkins University School of Medicine, Baltimore, Md., USA Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (2006) 75 (4): 199–201. https://doi.org/10.1159/000092889 Article history Published Online: June 19 2006 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Thomas N. Wise; Curiosity and Crisis. Psychother Psychosom 1 June 2006; 75 (4): 199–201. https://doi.org/10.1159/000092889 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. © 2006 S. Karger AG, Basel2006Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Maternal Rh immunization.
Authors: T M Allan
Journal: BMJ (1969)

BRItIH 301 low figures were found in all three cases of P.N.H. in which this test was performed.Ham's test and the sugar-lysis test were also strongly positive.A low figure of AChE (less than 0 550 pH units/hour) was also found in several cases of myeloproliferative disorder, including polycythaemia vera, myelo- sclerosis, di Guglielmo's disease, thrombo- cythaemia, and myeloid reticulosis.In some of these cases there was also slightly increased lysis in the sucrose-veronal buffer.Though there was not complete correlation between a low AChE and increased sugar lysis, the high proportion of abnormal results in the diseases under discussion supports Dameshek's5 speculation that they are con- nected.-Iam, etc.,
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
Authors: Hagop Kantarjian, Yasuhiro Oki, Guillermo Garcia-Manero, Xuelin Huang, Susan O'Brien, Jorge Cortes, Stefan Faderl, Carlos Bueso-Ramos, Farhad Ravandi, Zeev Estrov, Alessandra Ferrajoli, William Wierda, Jianqin Shan, Jan Davis, Francis Giles, Hussain I. Saba, Jean-Pierre J. Issa
Journal: Blood (2006)
Infections Due to Bacteroides and Fusobacterium: Findings in 102 Patients.
Authors: S. M. Finegold
Journal: Annals of Internal Medicine (1962)

s1 April 1962Infections Due to Bacteroides and Fusobacterium: Findings in 102 Patients.S. M. Finegold, M.D., F.A.C.P., W. L. Hewitt, M.D., F.A.C.P.S. M. Finegold, M.D., F.A.C.P.Search for more papers by this author, W. L. Hewitt, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-687_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInfections with anaerobic organisms belonging to the Bacteroides-Fusobacterium group are much more common than is generally appreciated. This paper is concerned with clinical and bacteriologic findings in 127 infections due to these organisms, occurring in 102 patients. These organisms were isolated from the blood stream in 11 cases; the portal of entry was the urinary tract in two; peritoneum, in three; meninges, in one; gastrointestinal tract, in two; and was unknown in three. One of these patients has had recurrent bacteremia for over one year and is thought to have subacute bacterial endocarditis. The organisms were isolated from the urine... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: S. M. Finegold, M.D., F.A.C.P.; W. L. Hewitt, M.D., F.A.C.P.Affiliations: Los Angeles, Calif. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 687-687KeywordsBacteremiaBacteroidesBloodEndocarditisGastrointestinal tractMeningesPeritoneumRiversUrine ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...
ADAPTABILITY OF SCIENTIFIC INFANT-FEEDING TO GENERAL PRACTICE
Authors: H. LOWENBURG
Journal: JAMA (1910)

Realizing that human milk is the best food for babies, the pediatrist determined to his own satisfaction long ago that, this failing, the best substitute is properly adapted cow's milk. To state that the percentage, fractional or American system of infant-feeding is a panacea for the nutritional ills of infants during the first year of life would be to adopt a fallacy and create a position readily made untenable. To regard this as the best and easiest means of adapting cow's milk to the digestive capacity of the individual is rational and scientific. It affords the best way of carrying the greatest number of feeding cases, both sick and well, to a successful issue. That it is not too intricate and complex for adoption by the general practitioner can be proved by demonstrating that failure results, not from the method, but from causes independent of it. For convenience these causes
Outcomes from carotid artery stenting in over 1,000 cases from a single group of operators
Authors: Gishel New, Gary S. Roubin, Sriram S. Iyer, George Dangas, Roxana Mehran, Yuliya G. Adamyan, Thosaphol Limpijankit, Christina Brennan, Palawi Kumar, Jiri J. Vitek
Journal: Journal of the American College of Cardiology (2003)
Abstract 3516: Targeting cancer by cisplatin-containing nanovectors
Authors: Poulomi Sengupta, Shivani Soni, Sudipta Basu, Shiladitya Sengupta
Journal: Cancer Research (2010)

Abstract Cisplatin [cis-dichlorodiammineplatinum(II)] is a first-line chemotherapeutic agent, and is widely used for the treatment of many malignancies including testicular, ovarian, cervical, head and neck, and non-small cell lung cancer. Its use is dose-limited mainly because of nephrotoxicity. To address this limitation, we have engineered novel nanovector to deliver the drug directly to the tumor site with reduced toxicity. In this study, we have functionalized cholesterol with succinic acid and ethyelene diammine to complex platinum through a monocarboxylato and a coordinate bond. The Chol-Pt complex was mixed with phosphatidylcholine and DSPE-PEG at 5:10:1 weight ratio and cisplatin containing nanoparticles were synthesized through evaporation-hydration-extrusion technique. The nanoparticles were found to be in the size range of 100-150 nm and spherical in morphology (characterized by DLS and TEM respectively). The physicochemical release kinetics of cisplatin from the nanoparticles in different hypoxic cell lysates showed a sustained release of the drug. Our in vitro studies of the cisplatin liposomes indicate that cisplatin liposomes are highly effective in 4T1 breast cancer and LLC (Lewis Lung Carcinoma) cell lines in 48 hours, as compared with free cisplatin. Most interestingly, our cisplatin containing liposomes demonstrated efficacy in cisplatin resistant CP20 (liver adenocarcinoma) cell line at 10 μM concentration. Hence, our study showed that our novel cisplatin nanovector delivery device could potentially be harnessed for lung, breast and cisplatin resistant cancer chemotherapy with increased therapeutic index compared to cisplatin. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3516.
Low-Friction Arthroplasty
Authors: N. Eftekhar
Journal: JAMA (1971)

When a new surgical technique or drug has reached a certain point in its development, a strict criterion for its use must be identified. A policy is outlined by which patients are to be selected for treatment by low-friction arthroplasty. Major complications such as thromboembolism or infection are discussed in detail. A special reference is made to tissue biocompatibility of material used in this procedure. It may be expected that at this interim stage of development of total hip replacement "misuse" is more likely from errors of selection of patients than from errors of surgical technique. It is recommended that widespread adoption of this procedure must be limited only to surgeons who are fully familiar with details of technique and management.
MIC trial: metoprolol in patients with mild to moderate heart failure: effects on ventricular function and cardiopulmonary exercise testing
Authors: Sabine Genth‐Zotz, Rainer J. Zotz, Martin Sigmund, Peter Hanrath, Dagmar Hartmann, Michael Böhm, Finn Waagstein, Norbert Treese, Jürgen Meyer, Harald Darius
Journal: European Journal of Heart Failure (2000)
Abstract 5929: Evaluation of Myocardial Substrate with MRI Late Gadolinium Enhancement Allows for Earlier Detection of Cardiac Involvement Compared with Morphological Assessment in Primary AL Amyloidosis
Authors: Imran Syed, James Glockner, DaLi Feng, Philip A Araoz, Matthew Martinez, Morie A Gertz, Angela Dispenzieri, Jae K Oh, Martha Grogan
Journal: Circulation (2008)

Objective: In AL amyloidosis, early detection of cardiac involvement is desirable because of prognostic and therapeutic implications. Recent pilot MRI studies have demonstrated that late gadolinium enhancement (LGE) is a common finding in cardiac amyloidosis (CA) and reflects interstitial expansion due to amyloid infiltration. However it is not known whether evaluation of the myocardial substrate via LGE MRI may allow for earlier detection of CA compared with morphological assessment on the basis of increased left ventricular thickness (LVT). Methods: Between January 2006 and December 2007, 100 patients with confirmed AL amyloidosis underwent LGE MRI at our institution to evaluate for CA. Morphological evidence of CA was considered to be present when LVT was increased (mean of septum and inferolateral wall &gt; 12 mm). LGE images were analyzed for presence and pattern of LGE. Clinical data was also reviewed. Results: Increased LVT was present in 69 patients. Abnormal LGE images were present in 76 patients (global diffuse transmural or subendocardial LGE in 43, suboptimally nulled myocardium in 18, and focal patchy LGE in 15 patients). LGE was present in 21 of 22 patients with a diagnosis of CA on cardiac biopsy. Seven patients (10%) with increased LVT did not have LGE. Conversely of 31 pts with normal LVT, 14 (45%) had abnormal LGE on MRI (usually suboptimally nulled myocardium or focal patchy LGE) and also had significantly higher incidence of low voltage ECG (50% vs. 0%), lower absolute limb lead voltage (6.5±3 vs. 9.7±2.6 mm), increased RV thickness (4.9±1.1 vs. 4.1±1) and higher BNP (316±376 vs. 107±103) compared to 17 patients without LGE (Table 1 ). Conclusions: MRI LGE is common in patients with CA and evaluation of the myocardial substrate using this technique may allow for earlier detection of cardiac involvement in AL amyloidosis compared with morphological assessment on the basis of increased LVT.