Werner's Syndrome
Authors: THOMAS R. RILEY
Journal: Annals of Internal Medicine (1965)

Case Studies1 August 1965Werner's SyndromeTHOMAS R. RILEY, M.D., RALPH G. WIELAND, M.D., JOHN MARKIS, B.A., GEORGE J. HAMWI, M.D., F.A.C.P.THOMAS R. RILEY, M.D.Search for more papers by this author, RALPH G. WIELAND, M.D.Search for more papers by this author, JOHN MARKIS, B.A.Search for more papers by this author, GEORGE J. HAMWI, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-285 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOtto Werner (1), as a medical student at the Ophthalmology Clinic in Kiel, studied four siblings with cataracts and scleroderma whom he described in 1904 in his doctoral dissertation. In 1868, Rothmund (2) had reported three families whose members were afflicted with cataracts and a peculiar telangiectatic dermatological condition. The similarity between these syndromes resulted in considerable confusion, and for years investigators did not distinguish one from the other. In 1934, Oppenheimer and Kugel (3) described for the first time in the American literature two patients similar to those of Werner. They emphasized the difference between these patients and those...References1. WERNER CW: Über Katarakt in Ver. bindung mit Sclerodermie, in Inaug. Dissert. Kiel, 1904. Google Scholar2. ROTHMUND A: Über Katarakt in Verbindung mit einer eigentumlichen Hautdegeneration. Arch. Opthal. (Chicago) 14: 159, 1868. Google Scholar3. OPPENHEIMERKUGEL BSVH: Werner's syndrome—a heredofamilial disorder with scleroderma, bilateral juvenile cataract, precocious graying of the hair and endocrine stigmatization. Trans. Ass. Amer. Physicians 49: 358, 1934. Google Scholar4. 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Author, Article, and Disclosure InformationAffiliations: Columbus, OhioFrom the Clinical Research Center and the Department of Medicine, Division of Endocrinology and Metabolism, Ohio State University Hospitals, Columbus, Ohio.This investigation was supported in part by Public Health Research Grant FR-34 (Clinical Research Center) and United States Public Health Service Training Grant TI AM 5118-08, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to George J. Hamwi, M.D., F.A.C.P., Professor of Medicine, Director, Division of Endocrinology and Metabolism, Department of Medicine, The Ohio State University Hospitals, 410 West 10th Avenue, Columbus, Ohio 43210. 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