tbuckley/cabot-search huggingface dataset:
Concomitant Hepatitis B Surface Antigen and Antibody
Authors: Alan I. Leibowitz, Adrian O. Vladutiu
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 April 1984Concomitant Hepatitis B Surface Antigen and AntibodyALAN I. LEIBOWITZ, M.D., ADRIAN O. VLADUTIU, M.D., PH.D.ALAN I. LEIBOWITZ, M.D.Search for more papers by this author, ADRIAN O. VLADUTIU, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-615_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently, Foutch and associates (1) reported the presence of hepatitis B surface antigen (HBsAg) and its antibody (anti-HBs) in 13 patients. The authors thought that this finding showed that certain persons developed two discrete infections with hepatitis B virus (HBV). Indeed, previous findings of the simultaneous presence of HBsAg and anti-HBs were explained by infections with two subtypes of HBV (2). The concomitant presence of HBsAg with true anti-HBs could be found, for a very short time, during the clearing of HBsAg after an acute infection.It is difficult to believe that the patients can clear an...References1. FOUTCHCAREYTABOR PWE. Concomitant hepatitis B surface antigen and antibody in thirteen patients. Ann Intern Med. 1983;99:460-3. LinkGoogle Scholar2. LEBOUVIERCAPPERWILLIAMSPELLETIERKATZ GRAMA. Concurrently circulating hepatitis B surface antigen and heterotypic anti-HBs antibody. J Immunol. 1976;117:2262-4. MedlineGoogle Scholar3. SZMUNESSSTEVENS WC. Hepatitis B vaccine in medical staff of haemodialysis units: efficacy of ad vaccine against ay hepatitis B virus infection. J Infection. 1983;7(suppl 1):9-13. CrossrefGoogle Scholar4. HEIJTINKVAN HATTUMSCHALMMASUREL RJSN. Co-occurrence of HBsAg and anti-HBs: two consecutive infections or a sign of advanced chronic liver disease? J Med Virol. 1982;10:83-90. CrossrefMedlineGoogle Scholar5. PALLATOTIALMIRECCHIARIZZIBONINO MMPSRF. Complexes between IgM and HBsAg in serum of HBsAg carriers. Ital J Gastroenterol. 1981;12:223-8. Google Scholar6. HEIJTINKKRUININGSCHALMMASUREL RJSN. Hepatitis B: prevaccination screening of individuals simultaneously positive for HBsAg and anti-HBs in one assay. Lancet. 1983;1:1050-1. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Serology of Viral Hepatitis Making Sense out of Alphabet SoupAntibodies to Hepatitis B Surface AntigenADRIAN O. VLADUTIU, M.D., Ph.D.Specificity of Tests for Antibody to Hepatitis B Surface Antigen in Patients with Concomitant Antibody and AntigenE. TABOR, M.D., R.J. GERETY, M.D., P.G. FOUTCH, D.O., W.D. CAREY, M.D. 1 April 1984Volume 100, Issue 4Page: 615-615KeywordsHepatitis B surface antigenHepatitis B virusInfectious hepatitis Issue Published: 1 April 1984 PDF downloadLoading ...
Tc-99m Glucoheptonate Imaging Retroperitoneal Abscess
Authors: JOHN R. STY, ROBERT G. WELLS
Journal: Clinical Nuclear Medicine (1990)

Technetium-99m glucoheptonate renal imaging was performed on an 8-year-old boy with flank pain and fever. The study demonstrated minimal delayed right renal function, but a rim of abnormal tracer accumulation was visible in the soft tissues of the right abdomen. Further evaluation with CT confirmed the presence Of a retroperitoneal multiloculated abscess in the right lower quadrant.
Controlled trial of physiotherapy and occupational therapy for Parkinson's disease.
Authors: F B Gibberd, N G Page, K M Spencer, E Kinnear, J B Hawksworth
Journal: BMJ (1981)

Controlled trial of physiotherapy and occupational therapy for Parkinson's diseasePhysiotherapy is used routinely in Parkinson's disease, but there are no properly controlled trials to support its use.We describe such a trial.
Scintigraphic Evidence of Asymptomatic Impaired Left Ventricular Function in Type I Diabetics
Authors: E K J PAUWELS, H H P J LEMKES, S GONSALVES, A LIQUI-LUNG, J A K BLOKLAND, J K RADDER
Journal: Clinical Nuclear Medicine (1985)

Asymptomatic myocardial disease has been described in relation to longstanding insulin-dependent diabetes mellitus. To detect myocardiopathy in a selected group of 14 patients (aged 21-38 years, duration of diabetes 10-20 years) with insulin-dependent diabetes, we have performed equilibrium gated nuclear angiography with Fourier filtered analysis. These patients had no clinical or echocardiographic signs of cardiac disease. We examined six patients with severe proliferative retinopathy, and eight patients with no signs of retinopathy at fluorescence angiography. The global ejection fraction was within normal limits in all cases. Fourier analysis of scintigraphic data, however, revealed wall motion abnormalities (abnormal amplitude and phase shift) of the left ventricle in all 14 patients, particularly in the anterior and/or septal region. No correlation was found between the degree of wall motion disturbances and prevailing blood glucose or HbA1 concentrations or the presence of retinopathy or autonomic neuropathy. It is concluded that equilibrium gated nuclear angiography in combination with Fourier filtered analysis is a sensitive method of detecting myocardial abnormalities in patients suffering from insulin-dependent diabetes mellitus without cardiac symptoms.
Localisation of e-antigen in nuclei of hepatocytes in HBsAg-positive liver diseases.
Authors: W Arnold, J O Nielsen, F Hardt, K H Meyer zum Buschenfelde
Journal: Gut (1977)

By the direct immunofluorescence technique 19 liver biopsies were examined for the presence of the e-antigen associated with the hepatitis B virus infection. With the use of double incubation and blocking experiments with FITC and Rhodamine labelled antisera against hepatitis B core antigen and e-antigen, evidence is presented that the e-antigen is localised in the nuclei of the hepatocytes. We conclude that the e-antigen and the core antigen are not identical, although they are often present simultaneously in the nucleus of the hepatocyte.
Effect of testing for human papillomavirus as a triage during screening for cervical cancer: observational before and after study
Authors: Sue Moss, Alastair Gray, Rosa Legood, Martin Vessey, Julietta Patnick, Henry Kitchener
Journal: BMJ (2006)

<h3>Abstract</h3> <b>Objective</b> To assess the effect of introducing testing for human papillomavirus combined with liquid based cytology in women with low grade cytological abnormalities. <b>Design</b> Observational before and after study. <b>Setting</b> Three cervical screening laboratories, England. <b>Participants</b> 5654 women aged 20-64 with low grade cytological abnormalities found at routine cervical screening in a pilot; 5254 similar women in the period before the pilot. <b>Interventions</b> Human papillomavirus testing combined with liquid based cytology in the management of women with borderline or mildly dyskaryotic cervical smear results compared with conventional smear tests, with immediate referral to colposcopy of women positive for human papillomavirus. <b>Results</b> 57.9% (3187/5506) of women tested in the pilot were positive for human papillomavirus. The rate of repeat smears fell by 74%, but the rate of referral to colposcopy for low grade cytological abnormalities more than doubled. The estimated negative predictive value of human papillomavirus testing varied between 93.8% and 99.7%. <b>Conclusion</b> The addition of testing for human papillomavirus in women with low grade cytological abnormalities resulted in a reduction in the rate of repeat smears, but an increase in rates of referral to colposcopy.
Propagation of Mouse Carcinoma by Dried Tumour Tissue
Authors: I. Mann, W. J. Dunn
Journal: BMJ (1949)

MEDICAL.JOURN~AL 7-added.It was sealed in ampoules containing 0.5 ml.6-each.These were frozen in a -solution of CO snow in z 5 "cellosolve " (ethylene glycol monoethyl ether, B.D.H.) 4 4 to -79°C.for varying 4s /// periods (from 15 minutes to 182 days).Each ampoule was then thawed, sometimes uj z /////_/by immersion in water at 3 / g / 2°C., sometimes by holding in the hand.(No difference l IDS/was noticed between the two ____,___,___ ,_ methods.)If it was to be a 2 tested it was opened, the NUMBER OF FREEZINGS AND contents drawn up into a THAWINGS syringe, and 0.05-0.1 ml. (as Chart showing rise in latent in Cramer's original experiperiod at successive freezings.ment) injected into the right mammary region of each mouse.Equal numbers of male and female mice were used,' all younger than the cancer age.
Molecular Diagnosis and Carrier Screening for β Thalassemia
Authors: Antonio Cao
Journal: JAMA (1997)

Thalassemias are common autosomal recessive disorders especially in populations of Mediterranean, Middle Eastern, and Far Eastern descent. Relatively high incidence is also observed in people of Asian Indian origin but the incidence is more limited in those of African descent. Beta Thalassemias are heterogeneous at the molecular level, with more than 150 different molecular defects identified to date. Despite this heterogeneity, each at-risk population has its own spectrum of common mutations, usually from 5 to 10, a finding that simplifies mutation analysis. Homozygosity for beta thalassemias usually results in transfusion-dependent thalassemia major and, rarely, in mild non-transfusion-dependent conditions. Molecular diagnosis may be used to define genotypes associated with mild forms. Advances in carrier diagnosis using hematologic analysis followed by mutation analysis have made possible the population screening of women at childbearing age and prenatal diagnosis. This approach in combination with nondirective genetic counseling has resulted in a consistent decline of the birth of affected homozygotes in several Mediterranean at-risk populations, as well as knowledge of the risks of being a carrier. Molecular diagnosis of homozygotes and identification of carriers of beta thalassemia may lead to improved clinical management of patients with the disorder and prevention of the birth of affected homozygotes.
Value of Serum Iron Levels in Assessing Effect of Haematinics in the Macrocytic Anaemias
Authors: C. F. Hawkins
Journal: BMJ (1955)

MARROW CELLS IN PERNICIOUS ANAEMIABEDICBAo>TsH 383 age groups is, however, significantly greater than in the younger groups (x2= 21.53; df = 6; P<0.001).Table III shows the percentage of medical beds occupied by patients with intracranial vascular lesions.The number of beds occupied by chronic cases, those who have been in TABLE III.-Percentage of Medical Beds Occupied by Intracranial Vascular Lesions Men Women Hospital A Hospital B Hospital A Hospital B All cases .. 147 2-13 3 07 4 08Cases in hospital more than: 2 weeks.. 0.
TCT-766 The Annulus Dimension is Crucial to Achieved Good Results in Pure Severe Native Aortic Regurgitation Treated by Transcatheter Aortic Valve Implantation
Authors: Marco Luciano Rossi, Paolo Pagnotta, Cristina Barbaro, Margherita Soldi, Patrizia Presbitero
Journal: Journal of the American College of Cardiology (2013)
PICK1 deficiency causes male infertility in mice by disrupting acrosome formation
Authors: Nan Xiao, Chuen Kam, Chong Shen, Wenying Jin, Junqi Wang, Kwong Man Lee, Liwen Jiang, Jun Xia
Journal: Journal of Clinical Investigation (2009)

Protein interacting with C kinase 1 (PICK1) is a peripheral membrane protein involved in protein trafficking, a function that has been well characterized in neurons. Here, we report that male mice deficient in PICK1 are infertile and have a phenotype resembling the human disease globozoospermia. The primary defect in the testes of Pick1-knockout mice was fragmentation of acrosomes in the early stages of spermiogenesis. This fragmentation was followed by defects in nuclear elongation and mitochondrial sheath formation, leading to round-headed sperm, reduced sperm count, and severely impaired sperm motility. We found that PICK1 interacted with Golgi-associated PDZ- and coiled-coil motif-containing protein (GOPC) and the primary catalytic subunit of protein kinase 2 (CK2alpha'), proteins whose deficiencies lead to globozoospermia in mice. PICK1 was highly expressed in round spermatids and localized to Golgi-derived proacrosomal granules. GOPC colocalized with PICK1 in the Golgi region and facilitated formation of PICK1-positive clusters. Furthermore, there was an increase in apoptosis in the seminiferous tubules of Pick1-/- mice, a phenotype also seen in CK2alpha'-deficient mice. Our results suggest that PICK1 is involved in vesicle trafficking from the Golgi apparatus to the acrosome and cooperates with other proteins such as GOPC and CK2alpha' in acrosome biogenesis.
COLLECTION OF URINE FROM FEMALE BABIES
Authors: William A. Lurie
Journal: JAMA (1913)

Having experienced some difficulty in the collection of urine from female baby patients, I decided that if I had any success  I would let others know and I now wish to describe a simple method which has proved satisfactory in my hands. I strapped a narrow cup from my cupping outfit to the abdomen and over the buttocks of my little patient in such a manner that the margins were in close approximation to the vulva. To the opposite end of the cup I attached a bit of rubber tubing, the other end of which was in a bottle which was either strapped to the patient's leg or left in the bed. I found that this simple device was satisfactory and required no watching. 5108 Wentworth Avenue.
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS
Authors: Elvin A. Kabat, Aaron Bendich, Ada E. Bezer, Sam M. Beiser
Journal: The Journal of Experimental Medicine (1947)

1. Blood group substances have been prepared from human saliva, stomach, and amniotic fluid from individuals of blood group A(1) and A(2). Several of the saliva samples were obtained from individuals shown to be heterozygous, A(1)O. 2. The purified blood group A substances from human sources were similar in nitrogen, glucosamine, reducing sugar, and acetyl content. The A(1) and A(2) substances differed in optical rotation. All of the human A samples were levorotatory while those from hog stomach were dextrorotatory. 3. By two immunochemical criteria the various human preparations could be shown to fall into distinct groups, with respect to purity. The best products showed maximal activity and almost all of their glucosamine was specifically precipitable by anti-A. These samples of human A substance were only about one-half as effective in precipitating antibody to hog A substance formed in man as was homologous hog A substance although the same total amount of antibody was precipitable by excess of either antigen. 4. Human blood group A(1) substance was found to be antigenic in individuals of blood groups B and O but was not as good an antigen as hog A substance.
Doctoring the Evidence: The Case Against Lying to Patients about Placebos
Authors: Beatrice A. Golomb
Journal: The American Journal of Bioethics (2009)

Click to increase image sizeClick to decrease image size Acknowledgment I thank Sabrina Koperski for excellent editorial and administrative assistance. Notes 1. There are exceptions. A high cancer burden now may predict a higher cancer burden later. The characteristics of the variable and the sample matter. 2. Thus, subjects in the JUPITER trial of statin therapy were selected for high values of C-reactive protein (CRP), an inflammatory marker: A marked drop in CRP on follow-up occurred in the placebo group (from 4.3 to 3.5 mg/L at 1 year) (CitationRidker 2008)—as expected by distributional principles, rather than placebo effects. 3. Subjects previously lower in the distribution may newly assume higher values at the later time: however these subjects did not qualify for participation and so are not tracked—fostering the spurious appearance that benefit is dominating. 4. There may be select circumstances, with national security at stake, in which I would accept this. But not lies to me, for my good.
Medical Department University of Wooster.
Authors: H. W. Rogers
Journal: JAMA (1894)

Cleveland, Ohio, Feb. 19, 1894. <h3>To the Editor:</h3> —Will you kindly correct a statement made in a recent issue of yourJournal, to the effect that Dr. F. C. Taylor was elected to the position of Secretary of our Faculty. Such is not the case. The writer is holding the position at the present time and has for some time previously. Very truly yours,
Transplacental transport of lead.
Authors: R A Goyer
Journal: Environmental Health Perspectives (1990)

Neurotoxicity is the major health effect from exposure to lead for infants and young children, and there is current concern regarding possible toxic effects of lead on the child while in utero. There is no placental-fetal barrier to lead transport. Maternal and fetal blood lead levels are nearly identical, so lead passes through the placenta unencumbered. Lead has been measured in the fetal brain as early as the end of the first trimester (13 weeks). There is a similar rate of increase in brain size and lead content throughout pregnancy in the fetus of mothers in the general population, so concentration of lead probably does not differ greatly during gestation unless exposure of the mother changes. Cell-specific sensitivity to the toxic effects of lead, however, may be greater the younger the fetus. Lead toxicity to the nervous system is characterized by edema or swelling of the brain due to altered permeability of capillary endothelial cells. Experimental studies suggest that immature endothelial cells forming the capillaries of the developing brain are less resistant to the effects of lead, permitting fluid and cations including lead to reach newly formed components of the brain, particularly astrocytes and neurons. Also, the ability of astrocytes and neurons to sequester lead in the form of lead protein complexes occurs only in the later stages of fetal development, permitting lead in maturing brain cells to interact with vital subcellular organelles, particularly mitochondria, which are the major cellular energy source. Intracellular lead also affects binding sites for calcium which, in turn, may affect numerous cell functions including neurotransmitter release.
Ethylene Oxide Dermatitis
Authors: Jon M. Hanifin
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Several cases are presented in which contact dermatitis occurred secondary to prepackaged wound dressing material containing excessive quantities of ethylene oxide used during sterilization. Ethylene oxide is a colorless gas widely used for sterilization of medical supplies and equipment. Cutaneous toxicity of this chemical has been known for many years and has received sporadic attention.<sup>1-3</sup> The increasing use of ethylene oxide in sterilization of anesthesia equipment has been paralleled by increasing numbers and varieties of toxic reactions.<sup>4</sup>This report describes a group of cases of contact dermatitis which were traced to ethylene oxide residuals in prepackaged gauze dressings. In addition to revealing an unusual source of ethylene oxide toxicity, this experience suggested relevance to many areas of medicine. <h3>Report of Cases.—Case 1.—</h3> A 21-year-old man who was seen two days after appendectomy had noted irritation beneath the wound dressing 24 hours after surgery.
SUPPLEMENTARY REPORT OF THE USE OF SALOL IN TYPHOID FEVER.
Authors: R. H. DAY
Journal: JAMA (1889)

In the last days of September, 1888, I was called to see a patient suffering from typhoid fever, and I was led by some recent studies of the composition and therapeutic effects of salol to give it a trial in the case before me. I did so, and with such prompt and decided success, that I deemed it my professional duty to report my experience at once to the medical profession. To this end I wrote up a report of the case for theJOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, and in the latter part of October forwarded it to the Editor, requesting its early publication. The Editor kindly accepted the article, and wrote me it would be printed as soon as it could be done injustice to other contributors. Unfortunately, perhaps, the publication of my article was long postponed, owing to the many excellent papers onTHE JOURNAL'Sfile
Biochemical, immunological and clinical characterization of a cross‐reactive nonspecific lipid transfer protein 1 from mulberry
Authors: M. A. Ciardiello, P. Palazzo, M. L. Bernardi, V. Carratore, I. Giangrieco, V. Longo, M. Melis, M. Tamburrini, D. Zennaro, A. Mari, P. Colombo
Journal: Allergy (2009)

Mulberry (Morus spp.) is a genus comprising several species of deciduous trees whose fruits are commonly eaten in southern Europe. Subjects with severe systemic reaction have been described. The aim of this study was to isolate the allergens of this species.A nonspecific lipid transfer protein 1 (ns-LTP1) was purified from black mulberry by ion exchange and reverse phase high-performance liquid chromatography, and the primary structure was elucidated by direct protein sequencing. Its allergenic activity was evaluated in vivo by skin prick test and in vitro by Western Blot, CD203c basophil activation assay and high throughput multiplex inhibition method on immunosolid-phase allergen chip (ISAC).Mulberry ns-LTP (Mor n 3) comprises 91 amino acids producing a molecular mass of 9246 Da. This protein shows high sequence identity with several allergenic ns-LTP1. Immunoblot analysis and CD203c activation assay demonstrated its allergenic activity in symptomatic subjects and in ns-LTP allergic patients who are not mulberry consumers. Immunological co-recognition was studied in vivo on a selected group of well-characterized ns-LTP allergic patients showing a high percentage of nMor n 3(+) subjects (88.46%) even in patients who have never eaten mulberry before. IgE inhibition on ISAC micro-array demonstrated an almost complete cross-reactivity to nArt v 3, rCor a 8 and a very high percentage of inhibition to nPru p 3.Mor n 3 is the first allergen isolated in black mulberry and immunologically characterized. It displayed allergenic activity among symptomatic and nonconsumer patients and a pattern of cross-reactivity to other plant-derived LTPs.
A randomized comparison ofrepeat stenting with balloon angioplasty in patients with in-stent restenosis
Authors: Fernando Alfonso, Javier Zueco, Angel Cequier, Ramón Mantilla, Armando Bethencourt, José R López-Minguez, Juan Angel, José M Augé, Manuel Gómez-Recio, César Morís, Ricardo Seabra-Gomes, María J Perez-Vizcayno, Carlos Macaya
Journal: Journal of the American College of Cardiology (2003)
House‐dust mites and mattresses
Authors: M. A. Schei, J. O. Hessen, E. Lund
Journal: Allergy (2002)

Background: Despite considerable efforts to develop anti dust mite strategies, surprisingly few studies have evaluated the allergen content in different types of mattresses in everyday use. This study investigated the presence of mite feces (an indicator of mite allergens) in foam and spring mattresses. Methods: The homes of 152 schoolchildren in Northern Norway were investigated. Dust samples were collected in a standardized way from 24 foam mattresses without covers, 68 foam mattresses with covers, and 24 spring mattresses, and the presence of mite feces detected by a guanine colorimetric paper test (Acarex). Results: We found mite feces in 15 (40.5%) of the dust samples from the foam mattresses without covers and 18 (26.3%) of the foam mattresses with covers. Only three (12.5%) of the spring mattresses contained detectable amounts of feces. Signs of dampness, age of mattress, cleaning of mattress, frequency of vacuuming the bedroom, mechanical ventilation, bedroom temperature and bedroom relative humidity were associated with the presence of mite feces. After adjustment for relevant confounders, the risk of finding mite feces was four times higher in foam compared to spring mattresses (odds ratio 4.0, 95% confidence interval (CI) 1.1–15.1), and eight times higher for the foam mattresses without cover (OR 8.1, 95% CI 1.8–36.9). Conclusion: A simple replacement of foam mattresses with spring mattresses may reduce the exposure to house‐dust‐mite allergens.