Resistance to Cephalothin in Vivo Associated with Increased Cephalosporinase Production
Authors: SHERWIN A. KABINS
Journal: Annals of Internal Medicine (1966)

Case Studies1 December 1966Resistance to Cephalothin in Vivo Associated with Increased Cephalosporinase ProductionSHERWIN A. KABINS, M.D., HELEN M. SWEENEY, M.S., SIDNEY COHEN, M.D., F.A.C.P.SHERWIN A. KABINS, M.D., HELEN M. SWEENEY, M.S., SIDNEY COHEN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-6-1271 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMicrobial resistance to penicillins or cephalosporins is often a consequence of enzymatic hydrolysis of the beta-lactam bond of the antibiotic. The enzymes involved have been designated collectively as beta-lactamases since, with few exceptions, they attack both penicillins and cephalosporins but often at very different rates (1). In spite of this designation, the specificity of these enzymes for the beta-lactam bond is not complete, for some of them may split certain simple peptide bonds (2). In individual bacterial species the degree of resistance conferred by a beta-lactamase is related to the enzymatic activity per cell. Accordingly a genetic mutation that led...References1. POLLOCK MR: Enzymes destroying penicillin and cephalosporin. Antimicrob. Agents Chemother. 4: 292, 1964. Google Scholar2. SAZLOWERY AKDL: Non-penicillin-like cyclic peptides as inducers and substrates for Bacillus cereus 569 penicillinase. Biochem. Biophys. Res. Commun. 19: 102, 1965. CrossrefGoogle Scholar3. KABINSCOHEN SAS: Resistance to cephalothin in vivo associated with increased cephalosporinase production (abstract). Clin. Res. 13: 296, 1965. Google Scholar4. FLEMINGGOLDNERGLASS PCMDG: Observations on the nature, distribution, and significance of cephalosporinase. Lancet 1: 1399, 1963. CrossrefMedlineGoogle Scholar5. NOVICK RP: Micro-iodometric assay for penicillinase. Biochem. J. 83: 236, 1962. CrossrefMedlineGoogle Scholar6. POLLOCK MR: Purification and properties of penicillinases from two strains of Bacillus licheniformis: a chemical, physiochemical and physiological comparison. Biochem. J. 94: 666, 1965. CrossrefMedlineGoogle Scholar7. BARBERWATERWORTH MPM: Penicillinase—resistant penicillins and cephalosporins. Brit. Med. J. 2: 344, 1964. CrossrefMedlineGoogle Scholar8. AYLIFFE GA: Cephalosporinase and penicillinase activity of gram-negative bacteria. J. Gen. Microbiol. 40: 119, 1965. CrossrefMedlineGoogle Scholar9. RICHMOND MH: Wild-type variants of exopenicillinase from Staphylococcus aureus. Biochem. J. 94: 584, 1965. CrossrefMedlineGoogle Scholar10. SMITH JT: Penicillinase and ampicillin resistance in a strain of Escherichia coli. J. Gen. Microbiol. 30: 299, 1963. CrossrefMedlineGoogle Scholar11. ERIKSSON-GRENNBERGBOMANJANSSONTHORÉN KGHGJAS: Resistance of Escherichia coli to penicillins. I. Genetic study of some ampicillin-resistant mutants. J. Bact. 90: 54, 1965. CrossrefMedlineGoogle Scholar12. DATTAKONTOMICHALOU NP: Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae. Nature (London) 208: 239, 1965. CrossrefMedlineGoogle Scholar13. WATANABE T: Infective heredity of multiple drug resistance in bacteria. Bact. Rev. 27: 87, 1963. CrossrefMedlineGoogle Scholar14. ABRAHAM EP: The cephalosporins. Pharmacol. Rev. 14: 473, 1962. MedlineGoogle Scholar15. COLESUTHERLAND MR: The role of penicillin acylase in the resistance of gram negative bacteria to penicillins. J. Gen. Microbiol. 42: 345, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, IllinoisFrom the Departments of Medicine and Microbiology, Michael Reese Hospital and Medical Center, Chicago, Ill. 60616.This study was supported by a grant from Eli Lilly & Co., Indianapolis, Ind., and by grant AI-02457-08, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Sherwin A. Kabins, M.D., Assistant to the Chairman, Department of Medicine, Michael Reese Hospital, Chicago, Ill. 60616. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Importance of β-Lactamases to the Development of New β-LactamsEvolution of β-Lactamases: Past, Present, and FutureBacterial resistance to penicillins and cephalosporinsThe Importance of β-Lactamases to the Development of New β-LactamsThe Chromosomal Beta-LactamasesStructure–Activity Relationships Among Semisynthetic Cephalosporins 1 December 1966Volume 65, Issue 6Page: 1271-1277KeywordsAntibiotic resistanceAntibioticsEnzymesEscherichia coliGeneticsHospital medicineMedical servicesMicrobiologyPenicillinSpecificity Issue Published: 1 December 1966 PDF downloadLoading ...