tbuckley/cabot-search huggingface dataset:
Lawyer's Advice
Authors: Terry J. Barnett
Journal: Annals of Internal Medicine (1991)

Letters1 September 1991Lawyer's AdviceTerry J. Barnett, JDTerry J. Barnett, JDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-5-409_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Lo and Steinbrook's fine article on the Cruzan case (1) suggests troubling issues about physician consultation with hospital attorneys. The authors say "lawyers might advise caregivers . . . to disregard advance directives to withhold artificial feedings unless laws are changed or test cases are decided." They cite cases in which patients were abusively subjected to other life-sustaining procedures after the physician received legal advice. Physicians should resist legal opinions that undermine their duties to patients, including the duty to respect a patient's wish not to be subjected to life-sustaining treatment.Hospital lawyers and physicians have fundamentally...Reference1. Lo B and Steinbrook R. Beyond the Cruzan case: the U.S. Supreme Court and medical practice. Ann Intern Med. 1991;114:895-901. LinkGoogle Scholar1. Lo B and Steinbrook R. Beyond the Cruzan case: the U.S. Supreme Court and medical practice. Ann Intern Med. 1991;114:895-901. LinkGoogle Scholar2. Walsh E. Recasting right-to-die: public hospital seeks to end life support. The Washington Post. 1991;29 May:A1. MedlineGoogle Scholar3. Walsh E. Spouse says he'd never agree to cut life support: "miracle" may happen, Minnesota court told. The Washington Post. 1991;30 May:A3. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Terry J. Barnett, JDAffiliations: 5212 Second Avenue N.W. Seattle, WA 98107 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1991Volume 115, Issue 5Page: 409-410KeywordsCaregivers ePublished: 1 December 2008 Issue Published: 1 September 1991 PDF downloadLoading ...
Complete remission of multiple satellite and in-transit melanoma metastases after sequential treatment with isolated limb perfusion and topical imiquimod
Authors: J. Utikal, A. Zimpfer, A. Thoelke, R. Figl, R. Hildenbrand, C. Kettelhack, S. Goerdt, D. Schadendorf, S. Ugurel
Journal: British Journal of Dermatology (2006)
ANGIOKERATOMA OF THE VULVA
Authors: CICELY BLAIR
Journal: British Journal of Dermatology (1970)

Journal Article ANGIOKERATOMA OF THE VULVA Get access CICELY BLAIR CICELY BLAIR Oldchurch Hospital, Romford, Essex Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 83, Issue 3, 1 September 1970, Pages 409–411, https://doi.org/10.1111/j.1365-2133.1970.tb15727.x Published: 01 September 1970 Article history Accepted: 20 March 1970 Published: 01 September 1970
Asthma Phenotypes and Interleukin-13 — Moving Closer to Personalized Medicine
Authors: Monica Kraft
Journal: New England Journal of Medicine (2011)

Asthma is a chronic inflammatory disease of the airways manifested by reversible airflow obstruction and airway hyperresponsiveness.1 One of the challenges of treating patients with asthma is the known heterogeneity of the disease and differential responses to standard treatments.24 For example, in a large clinical trial of patients with moderate asthma, one of three patients had asthma that was not well controlled despite the regular use for 1 year of fluticasone, an inhaled glucocorticoid, and salmeterol, a long-acting beta-agonist.3 In another study involving patients with more severe asthma, 40% were unable to gain control of their asthma with the . . .
Blast Cell Crisis in Acute Leukemia
Authors: Fred Rosner
Journal: JAMA (1976)

<h3>To the Editor.—</h3> It is unfortunate that Hoagland and Perry (235:1888-1889, 1976) have chosen to use the term "blast cell crisis" to denote massive leukocytosis (more than 100,000 WBCs per cubic milliliter) in patients with acute lymphoblastic and nonlymphoblastic leukemia. The term blast cell crisis is usually reserved for the blastic transformation of one of the myeloproliferative disorders, most commonly chronic granulocytic leukemia. Extreme or massive leukocytosis seems to be an appropriate and accurate designation for the emergent clinical situation described by Hoagland and Perry. Leukapheresis for the rapid removal of blast and other immature cells, using either a cell separator or a centrifuge, may be a highly effective method but must still be considered experimental. Furthermore, it is only a temporary, albeit possibly life-saving, measure to reduce the high leukocyte count and must be followed by more definitive therapy for the leukemia.
CASE OF GLANDERS IN A FEMALE
Authors: Archd. Wm. Cockburn
Journal: BMJ (1853)

ORIGINAL COMKUNIATTNS.0 taken place, that these tubes were dilated to a calibre equalling that of the small intestines, which, indeed, they greatly resembled.Moreover, the valves of the kidneys were likewise much dilated, and the cortical substance diminished to a corresponding extent, for the glands them- selves were not enlarged.
Safety of Genetically Modified Mosquitoes—Reply
Authors: Graciela R. Ostera, Lawrence O. Gostin
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The “Fetus as Patient”: A Critique
Authors: Stephen D. Brown
Journal: The American Journal of Bioethics (2008)

Click to increase image sizeClick to decrease image size This work was supported in part by awards from the Office of Faculty Development, Children's Hospital Boston and the American Roentgen Ray Society Leonard Berlin Scholarship. I would like to express my deep gratitude to Dan Wikler and Judy Johnson for their invaluable insights and commentary. I also thank Nancy Drinan for her help in manuscript preparation.
492. Harvest Timing and Media Composition Effects on Lentiviral Vector Production
Authors: Christopher Ballas, Terry Johnson, Kenneth Cornetta
Journal: Molecular Therapy (2005)

The Indiana University Vector Production Facility (IUVPF), in conjunction with the National Gene Vector Laboratories, has been developing the capability to produce and process a volume of lentiviral vector sufficient for phase I/II clinical trials. To date, the facility has been able to produce vector in Nunc Cell Factories in unprocessed volumes from 120mL to 20L in a single production run. In the course of developing this capability, we have looked at many production parameters and here report on the effects of harvest timing and media composition. The general production scheme had cells seeded into appropriate tissue culture flasks on day 1, cells were transfected by CaPO4 on day 2, DMEM+10% FBS medium (D10) was changed to harvest medium on day 3 followed by harvest of vector supernatant at indicated time points thereafter. Results are primarily reported as relative comparisons within each experiment. We have used p24 capsid protein ELISA as a physical method of estimating titer. For production using transgene vectors containing the GFP gene, the p24 data was supplemented with GFP expression titers determined by limiting dilution of vector on 293 cells. Harvest timings of 12, 24, 48 and 72 and multiple harvests at 12 and 24 hours after the post transfection media change had a range of GFP expression titers from 1.2|[times]|105 to 2.7|[times]|107 TU/mL. The initial 12 hour harvest had the highest titer, 2.7|[times]|107, but multiple harvests at 12 hour intervals resulted in a rapid drop in titer. The 24 hour harvests were found to be relatively consistent, usually only differing by a factor of 2.
Letter: Wartime penicillin.
Authors: I Fraser
Journal: BMJ (1974)

24 August, p. 520) by our suggestion that beta-adrenergic blocking agents should not be used in patients with moderately severe renal failure (27 April, p. 193).They refer to a previous publication' to show that temporary deterioration in renal function in such patients may occur with the introduction of any hypotensive drug.Their evidence appears to be based on experience with one patient with malignant hypertension who was given 6 different drugs, and is not relevant to the cases described by us.We refer Drs.Kincaid-Smith and Hua to our paper, where they will find that the maximum change in diastolic blood pressure in any of the three cases was 10 mm Hg during the period that renal function deteri- orated.Their comments do not shed any light on the mechanism of the events we described.Drs. Kincaid-Smith and Hua will no doubt agree that renal function should be moni- tored during the course of therapy with hypotensive drugs in patients with renal failure.Our exoerience leads us to suggest that this may be especially important when beta-blocking drugs are prescribed and needs to be emphasized now that these agents are being so forcefully promoted in general prac- tice.-Weare, etc.,
IMPACT OF INITIAL RECORDED RHYTHM ON CARDIAC ARREST PATIENTS TREATED WITH EXTRACORPOREAL CARDIOPULMONARY RESUSCITATION
Authors: Eisuke Kagawa, Ichiro Inoue, Takuji Kawagoe, Masaharu Ishihara, Yuji Shimatani, Satoshi Kurisu, Yasuharu Nakama, Kazuoki Dai, Takayuki Otani, Hiroki Ikenaga, Yoshimasa Morimoto, Kentaro Ejiri, Nozomu Oda
Journal: Journal of the American College of Cardiology (2010)
A clinical trial with hydrocortisone butyrate cream in eczema
Authors: M.K. POLAND, P. KANAAR
Journal: British Journal of Dermatology (2006)

In a double blind trial 0·1% hydrocortisone butyrate cream gave after a week a significantly better therapeutic response in eczema than 0·1% triamcinolone acetonide (P<0·05) and hydrocortisone acetate. The methods for clinical trials are discussed.
Smooth Muscle Cell Proliferation Is Proportional to the Degree of Balloon Injury in a Rat Model of Angioplasty
Authors: Ciro Indolfi, Giovanni Esposito, Emilio Di Lorenzo, Antonio Rapacciuolo, Antonio Feliciello, Antonio Porcellini, Vittorio E. Avvedimento, Mario Condorelli, Massimo Chiariello
Journal: Circulation (1995)

Background A variable degree of smooth muscle cell (SMC) proliferation after balloon injury has been reported in previous rat studies. It is unknown whether balloon injury induces c- fos expression and whether it is related to the degree of vascular injury in vivo. Therefore, we tested the hypothesis that proportional increases in neointimal formation and c- fos expression might be present after different degrees of balloon dilation. Methods and Results Angioplasty of the carotid artery was performed with a balloon catheter. Vascular injury was evaluated at 0, 0.5, 1.0, 1.5, and 2 atm (n=6 for all). In 40 additional rats, total RNA dot blots were performed to assess the effect of various degrees of balloon injury on c- fos expression. SMC proliferation proportional to the increases of inflation pressure was found between 0 and 2 atm with neointimal areas of 0.002±0.002, 0.069±0.014, 0.128±0.043, 0.190±0.010, and 0.255±0.041 mm 2 , respectively. When the degree of SMC proliferation (neointima and neointima/media ratio) was plotted against balloon inflation pressure, a linear relation was observed ( r =.733, P &lt;.001 and r =.755, P &lt;.001, respectively). An increase in c- fos expression proportional to the degree of injury was found 30 minutes after injury. Conclusions Neointimal proliferation produced by balloon injury is related to balloon inflation pressure, supporting the concept of an SMC proliferative response proportional to the degree of injury. The increase in SMC proliferation is associated with a proportional increase in the early expression of the c- fos nuclear proto-oncogene.
Clinical Psychiatric Medicine
Authors: John P. Callan
Journal: JAMA (1982)

Psychiatry is redefining its identity once more. Psychiatrists are shifting from a major emphasis on psychodynamics, psychotherapy, and psychological causes of disease to a closer alliance with clinical and laboratory medicine. Ten years ago, few social or vocational ills were considered to be outside the realm of psychiatry; many psychiatrists naively thought themselves then to be as well equipped to fight poverty as psychosis. They actively threw themselves into the social fray and enthusiastically assisted in developing a network of community mental health centers throughout the country. But their energetic efforts were not greeted with the success they had anticipated, and the limitations of psychiatry in the social sphere became apparent. The incidence and prevalance of mental illness have not dropped in the past decade. Now, the community mental health centers are staffed largely with social workers, and psychiatrists are turning from the psychosocial arena toward a more limited medical
Atenolol self-poisoning.
Authors: F L Shanahan, T B Counihan
Journal: BMJ (1978)

for skilled advice on occupational health matters, and in consequence many previously neglected environmental problems have come to light which call for medical help.It is the duty of those who undertake to advise them to make it plain that these are the important tasks, and that occupational medicine does not consist of routine examinations of new employees on the pretence that the doctor can forecast future sickness absence experience or survival.
A New Era in Reproductive Technology
Authors: M M Seibel
Journal: New England Journal of Medicine (1988)

IT has been estimated that there are at least 2.8 million infertile couples in the United States who want to have children.1 A decade ago many of these couples remained childless, despite the many advances in reproductive endocrinology and in the treatment of infertility. In 1978, however, the birth of the first baby conceived by in vitro fertilization ushered in a new era of reproductive technology.2 More than 3000 children have now been born as a result of this technique. Several hundred centers throughout the world perform in vitro fertilization, and there are currently more than 100 such centers in . . .
Thrombolysis of a Massive Pulmonary Embolism
Authors: Neil P Fam, Atul Verma
Journal: New England Journal of Medicine (2002)

Figure 1. A 52-year-old man with chronic left bundle-branch block presented with exertional syncope but no chest pain, palpitations, or dyspnea. His blood pressure was 95/60 mm Hg, and examination revealed signs of right ventricular failure and ascites. Transthoracic echocardiography revealed right ventricular dilatation and hypokinesis, with moderate tricuspid regurgitation and an estimated right ventricular systolic pressure of 55 mm Hg. Doppler studies of the legs showed bilateral proximal deep venous thrombosis, making the diagnosis of pulmonary embolism likely. Paracentesis and cytologic analysis of ascitic fluid revealed metastatic adenocarcinoma. Seven days after presentation, the patient had multiple episodes of arterial . . .
The Role of Tc-99m Dimercaptosuccinic Acid Renal Cortical Scintigraphy in Acute and Recurrent Episodes of Renal Infarction in a Patient With a Tendency Toward Thrombosis
Authors: Nazm Barş Kanat, Mehmet Aslan, Murat Fani Bozkurt, Eser Lay Ergün
Journal: Clinical Nuclear Medicine (2009)

Tc-99m dimercaptosuccinic acid (DMSA) renal cortical scintigraphy (RCS) of a 46-year-old man with abdominal and right flank pain who had history of a tendency toward thrombosis revealed extensive renal parenchymal changes secondary to renal infarction and a small size defect in the right kidney in addition to the patient's prior computed tomography results. The patient had Coumadin treatment. Two months later, he was referred to the hospital with the same symptoms. DMSA RCS established that the small defect in the right kidney had enlarged; other scarred areas persisted. This case indicates the value of DMSA RCS for early diagnosis, follow-up of acute/recurrent renal parenchymal scarring in patients with thrombophilia.
Sodium Etidronate in the Treatment of Paget's Disease of Bone
Authors: M. R. A. KHAIRI
Journal: Annals of Internal Medicine (1977)

Subjects (109) with symptomatic Paget's disease of bone were treated with 5, 10, or 20 mg of sodium etidronate (EHDP)/kg body weight day for 6 to 24 months. Significant decreases in serum alkaline phosphatase and urinary hydroxyproline were noted after 6 months of therapy; no significant further improvement resulted after prolonged therapy. Some patients maintained biochemical remission after withdrawal of EHDP but others showed a relapse, related primarily to the pretreatment severity. Clinical improvement was noted in 61% of the patients. Similar findings were seen after a second course of EHDP. No side-effects were noted in patients treated with 5 mg of EHDP/kg body weight day. In patients treated with 10 or 20 mg of EHDP/kg body weight day, severe diarrhea, bone pain, and nontraumatic fractures were noted in 3, 13, and 12 patients respectively. Quantitative histomorphometry showed mineralization delay in patients receiving 10 or 20 mg of EHDP/kg body weight day but not in those receiving 5 mg/kg body weight day. Five milligrams of EHDP/kg body weight day was effective and appears to be safer than the higher doses.
Induction of omega-oxidation of monocarboxylic acids in rats by acetylsalicylic acid.
Authors: R K Kundu, J H Tonsgard, G S Getz
Journal: Journal of Clinical Investigation (1991)

The accumulation of dicarboxylic acids, particularly long chain, is a prominent feature of Reye's syndrome and diseases of peroxisomal metabolism. We assessed the omega-oxidation of a spectrum of fatty acids in rats and asked whether pretreatment of rats with aspirin, which is known to predispose children to Reye's syndrome, would affect omega-oxidation of long chain fatty acids. We found that aspirin increased liver free fatty acids and increased the capacity for omega-oxidation three- to sevenfold. Omega-oxidation of long chain substrate was stimulated to a greater degree than medium chain substrate and was apparent within one day of treatment, at serum aspirin concentrations below the therapeutic range in humans. The apparent Km for lauric acid was 0.9 microM and 12 microM for palmitate. We also found a difference in the storage stability of activity toward medium and long chain substrate. Saturating concentrations of palmitate had no effect on the formation of dodecanedioic acid, whereas laurate decreased but never eliminated the omega-oxidation of palmitate. 97% of the total laurate omega-oxidative activity recovered was found in the microsomes, but 32% of palmitate omega-oxidative activity was present in the cytosol. These results demonstrate that aspirin is a potent stimulator of omega-oxidation and suggest that there may be multiple enzymes for omega-oxidation with overlapping substrate specificity.
Efficacy and Safety of Oral Dofetilide in Converting to and Maintaining Sinus Rhythm in Patients With Chronic Atrial Fibrillation or Atrial Flutter
Authors: Steven Singh, Robert G. Zoble, Laurence Yellen, Michael A. Brodsky, Gregory K. Feld, Martin Berk, Clare B. Billing
Journal: Circulation (2000)

Background —This double-blind, multicenter, placebo-controlled study determined the efficacy and safety of dofetilide in converting atrial fibrillation (AF) or atrial flutter (AFl) to sinus rhythm (SR) and maintaining SR for 1 year. Methods and Results —Patients with AF or AFl (n=325) were randomized to 125, 250, or 500 μg dofetilide or placebo twice daily. Dosages were adjusted for QTc response and, after 105 patients were enrolled, for calculated creatinine clearance (Cl Cr ). Pharmacological cardioversion rates for 125, 250, and 500 μg dofetilide were 6.1%, 9.8%, and 29.9%, respectively, versus 1.2% for placebo (250 and 500 μg versus placebo; P =0.015 and P &lt;0.001, respectively). Seventy percent of pharmacological cardioversions with dofetilide were achieved in 24 hours and 91% in 36 hours. For the 250 patients who successfully cardioverted pharmacologically or electrically, the probability of remaining in SR at 1 year was 0.40, 0.37, 0.58 for 125, 250, and 500 μg dofetilide, respectively, and 0.25 for placebo (500 μg versus placebo, P =0.001). Two cases of torsade de pointes occurred, 1 on day 2 and the other on day 3 (0.8% of all patients given active drug); 1 sudden cardiac death, classified as proarrhythmic, occurred on day 8 (0.4% of all patients given active drug). Conclusions —Dofetilide, a new class III antiarrhythmic agent, is moderately effective in cardioverting AF or AFl to SR and significantly effective in maintaining SR for 1 year. In-hospital initiation and dosage adjustment based on QTc and Cl Cr are necessary to minimize a small but nonnegligible proarrhythmic risk.
The Effect of Repeated Exposure to Particulate Air Pollution (PM<sub>10</sub>) on the Bone Marrow
Authors: HIROSHI MUKAE, RENAUD VINCENT, KEVIN QUINLAN, DEAN ENGLISH, JENNIFER HARDS, JAMES C. HOGG, STEPHAN F. van EEDEN
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Studies have shown that exposure to ambient particulate matter is related to an increased cardiopulmonary morbidity and mortality. The present study was designed to measure the effect of repeated exposure to urban air particles (PM10) on the rate of production and release of polymorphonuclear leukocytes (PMN) from the bone marrow into the peripheral blood. Rabbits exposed to PM10 (5 mg) twice a week for 3 wk, were given a bolus of 5'-bromo-2'-deoxyuridine (BrdU) to label dividing cells in the marrow that allows us to calculate the transit time of PMN in the bone marrow mitotic and postmitotic pools. The PM10 exposure (n = 8) causes a persistent increase in circulating band cells (p < 0.05) and a shortening of the transit time of PMN through the postmitotic pool in the marrow (64.4 +/- 2.2 h to 56.3 +/- 2.2 h, p < 0.05) if compared with vehicle-exposed control subjects (n = 6). PM10 exposure increases the bone marrow pool of PMN particularly the mitotic pool of PMN (p < 0.05). The PM10 were distributed diffusely in the lung and caused a mild mononuclear inflammation. The percentage of alveolar macrophages containing PM10 correlated significantly with the bone marrow PMN pool size (total pool r2 = 0.56, p < 0.012, mitotic pool r2 = 0.61, p < 0.007) and the transit time of PMN through the postmitotic pool (r2 = -0.42, p < 0.043). We conclude that repeated exposure to PM10 stimulates the bone marrow to increase the production of PMN in the marrow and accelerate the release of more immature PMN into the circulation. The magnitude of these changes was related to the amount of particles phagocytosed by alveolar macrophages.
The Hillsborough tragedy.
Authors: J Wardrope, F Ryan, G Clark, G Venables, A C Crosby, P Redgrave
Journal: BMJ (1991)

Liverpool and Nottingham Forest met at Hillsborough football stadium for an FA Cup semifinal match.The ensuing crush disaster, in which 95 spectators were killed, has been studied in an official Presentation and disposal ofpatients Most of the seriously injured arrived at the hospital within the first 30 minutes.Thirteen patients were