tbuckley/cabot-search huggingface dataset:
Abstract 223: Targeting PDK-1 and EGFR by human umbilical cord blood stem cells reverses Warburg effect in glioblastoma multiforme.
Authors: Kiran Kumar Velpula, Arnima Bhasin, Venkata Ramesh Dasari, Swapna Asuthkar, Dzung H. Dinh, Jasti S. Rao, Andrew J. Tsung
Journal: Cancer Research (2013)

Abstract Glioblastoma multiforme (GBM) is the most aggressive and incurable brain tumor in adults. The overexpression of epidermal growth factor receptor (EGFR) in GBM is identified as typical oncogenic signature. Due to the functional diversity of proteins that are phosphorylated or complexed with EGFR, it unsurprising that EGFR is involved in multiple interconnected signaling pathways. In GBM, hypoxia drives aggression and malignancy through glycolysis as opposed to oxidation of pyruvate in the mitochondria. This phenomenon, termed the Warburg effect, has a prominent role in oncogenesis. In the present study, we show that hypoxia induces pyruvate dehydrogenase kinase 1 (PDK-1) expression, which in turn increases the expression of EGFR and hypoxia inducing factor 1 alpha (HIF-1α) in cell lines derived from human GBM. PDK-1 is a HIF-1-regulated gene, and our data suggested that hypoxia-induced PDK-1 expression may promote EGFR activation, thus sustaining a feed-forward loop for malignant progression. PDK-1 and EGFR knockdown, using respective shRNAs or human umbilical cord blood stem cells (hUCBSC), lowers PDK-1-EGFR phosphorylation and decreases HIF-1α expression, which reverts the Warburg phenotype of GBM leading to inhibition of tumor- growth and invasion. Clinically, expression of PDK1, EGFR, and HIF-1α were elevated in GBM specimens when compared to normal brain tissues. Collectively, our studies indicate PDK-1 as a key mediator of tumor growth in GBM and that targeting PDK-1 and its associated molecules such as HIF-1α and EGFR may prove promising for inhibition of the Warburg effect in human GBMs. Citation Format: Kiran Kumar Velpula, Arnima Bhasin, Venkata Ramesh Dasari, Swapna Asuthkar, Dzung H. Dinh, Jasti S. Rao, Andrew J. Tsung. Targeting PDK-1 and EGFR by human umbilical cord blood stem cells reverses Warburg effect in glioblastoma multiforme. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 223. doi:10.1158/1538-7445.AM2013-223
Re: Mani Menon, Akshay Sood, Mahendra Bhandari, et al. Robotic Kidney Transplantation with Regional Hypothermia: A Step-by-step Description of the Vattikuti Urology Institute–Medanta Technique (IDEAL Phase 2a). Eur Urol 2014;65:991–1000
Authors: Jyotirmoy Das, Sudhir Kumar, Sangeeta Khanna, Yatin Mehta
Journal: European Urology (2014)
Alcohol and the Liver: 1984 Update
Authors: Charles S. Lieber
Journal: Hepatology (1984)

HepatologyVolume 4, Issue 6 p. 1243-1260 ArticleFree Access Alcohol and the Liver: 1984 Update Charles S. Lieber, Corresponding Author Charles S. Lieber Section of Liver Disease and Nutrition and Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center and the Mount Sinai School of Medicine (CUNY), New York, New York 10468Charles S. Lieber, M.D., Alcohol Research and Treatment Center, Veterans Administration Medical Center, 130 West Kingsbridge Road, Bronx, New York 10468.===Search for more papers by this author Charles S. Lieber, Corresponding Author Charles S. Lieber Section of Liver Disease and Nutrition and Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center and the Mount Sinai School of Medicine (CUNY), New York, New York 10468Charles S. Lieber, M.D., Alcohol Research and Treatment Center, Veterans Administration Medical Center, 130 West Kingsbridge Road, Bronx, New York 10468.===Search for more papers by this author First published: November‐December 1984 https://doi.org/10.1002/hep.1840040625Citations: 125AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume4, Issue6November‐December 1984Pages 1243-1260 ReferencesRelatedInformation
Failure of a Tapering Dose of Oral Methylprednisolone to Treat Reactions to Poison Ivy
Authors: Timothy J. Ives, Robyn Schuler Tepper
Journal: JAMA (1991)

<h3>To the Editor.</h3> —During the poison ivy season, the use of an oral corticosteroidtapering regimen is prescribed routinely for cases unresponsive to topical preparations. One of the most commonly prescribed corticosteroid products, Medrol Dosepak (Upjohn Co, Kalamazoo, Mich), is a 6-day tapering course of oral methylprednisolone. Anecdotal reports abound about flare-ups of severe cases of<i>Rhus</i>dermatitis within several days after completion of this product, but no documentation of this reaction exists, either in the medical literature or from the manufacturer. We have found that a tapering dose of prednisone over 12 days has not been associated with another flare-up of symptoms in severe cases of<i>Rhus</i>dermatitis. We report the use of this regimen in a case that is representative of this patient population. <h3>Report of a Case.</h3> —A 32-year-old woman presented with a complaint of recurrent poison ivy for the past 5 days. While backpacking 2 weeks previously,
The Impact of Transcatheter Aortic Valve Implantation on Pulmonary Hypertension
Authors: Tahir Durmaz, Hüseyin Ayhan, Telat Keleş, Abdullah Nabi Aslan, Haci Ahmet Kasapkara, Cenk Sarı, Emine Bilen, Nihal Akar Bayram, Murat Akçay, Engin Bozkurt
Journal: Journal of the American College of Cardiology (2013)
Lifestyle modification may be beneficial in diabetes care
Authors: S J Redmond
Journal: BMJ (2000)

EDITOR—I am moved to write to you for the first time in over 20 years as a BMA member in response to the editorial by Byrne and Wild on diabetes care.1 This includes the statement that the benefits of controlling weight, stopping smoking, increasing physical activity, and eating a Mediterranean diet have not been shown for people with diabetes. Hence we should treat them instead with a large range …
What is the critical evidence favoring expectancy bias theory, and where is it?
Authors: Andrew J. Tomarken
Journal: Behavioral and Brain Sciences (1995)

Abstract Davey has failed to clarify the critical evidence that could corroborate the expectancy bias hypothesis and refute preparedness theory. Such a clarification is necessary because each theory could potentially allow for multiple distal and proximal influences on selective associations. Expectancies are not the only proximal mediators. Our recent findings indicate that affective response matching may be an additional factor promoting such associations.
Deregulation of TWIST-1 in the CD34+ compartment represents a novel prognostic factor in chronic myeloid leukemia
Authors: Erika Cosset, Ghassan Hamdan, Sandrine Jeanpierre, Thibault Voeltzel, Karen Sagorny, Sandrine Hayette, François-Xavier Mahon, Charles Dumontet, Alain Puisieux, Franck E. Nicolini, Véronique Maguer-Satta
Journal: Blood (2010)
Erythema in the primary lesion of superficial spreading melanoma is not of prognostic importance
Authors: D.I. McLEAN, R.A. LEW, A.J. SOBER, M.C. MIHM, T.B. FITZPATRICK
Journal: British Journal of Dermatology (1982)

Journal Article Erythema in the primary lesion of superficial spreading melanoma is not of prognostic importance Get access D.I. McLEAN, D.I. McLEAN Section of Dermatologic Oncology, Division of Dermatology, University of British Columbia, Cancer Control Agency of British Columbia, Vancouver, Canada (DIM), and Department of Dermatology and Dermatopathology Unit, Harvard Medical School, Massachusetts General Hospital *, Boston, Massachusetts Dr D.McLean, Section of Dermatologic Oncology, 865 West 10th Avenue, Vancouver, B.C., Canada V5Z 1L7. Search for other works by this author on: Oxford Academic Google Scholar R.A. LEW, R.A. LEW Section of Dermatologic Oncology, Division of Dermatology, University of British Columbia, Cancer Control Agency of British Columbia, Vancouver, Canada (DIM), and Department of Dermatology and Dermatopathology Unit, Harvard Medical School, Massachusetts General Hospital *, Boston, Massachusetts Search for other works by this author on: Oxford Academic Google Scholar A.J. SOBER, A.J. SOBER Section of Dermatologic Oncology, Division of Dermatology, University of British Columbia, Cancer Control Agency of British Columbia, Vancouver, Canada (DIM), and Department of Dermatology and Dermatopathology Unit, Harvard Medical School, Massachusetts General Hospital *, Boston, Massachusetts Search for other works by this author on: Oxford Academic Google Scholar M.C. MIHM, JR, M.C. MIHM, JR Section of Dermatologic Oncology, Division of Dermatology, University of British Columbia, Cancer Control Agency of British Columbia, Vancouver, Canada (DIM), and Department of Dermatology and Dermatopathology Unit, Harvard Medical School, Massachusetts General Hospital *, Boston, Massachusetts Search for other works by this author on: Oxford Academic Google Scholar T.B. FITZPATRICK T.B. FITZPATRICK Section of Dermatologic Oncology, Division of Dermatology, University of British Columbia, Cancer Control Agency of British Columbia, Vancouver, Canada (DIM), and Department of Dermatology and Dermatopathology Unit, Harvard Medical School, Massachusetts General Hospital *, Boston, Massachusetts Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 3, 1 September 1982, Pages 339–342, https://doi.org/10.1111/j.1365-2133.1982.tb00364.x Published: 01 September 1982 Article history Accepted: 21 December 1981 Published: 01 September 1982
Frequency of Lymph Node Metastasis According to the Size of Tumors in Resected Pulmonary Adenocarcinoma with a Size of 30 mm or Smaller
Authors: Yangki Seok, Hee Chul Yang, Tae Jung Kim, Kyung Won Lee, Kwhanmien Kim, Sanghoon Jheon, Sukki Cho
Journal: Journal of Thoracic Oncology (2014)

This study analyzed the relation between the tumor size and the lymph node metastasis in adenocarcinoma of the lung with a size of 30 mm or smaller.Four hundred thirteen patients who had undergone curative resection for lung adenocarcinoma were enrolled. If the tumor presented ground-glass opacities on the preoperative high-resolution computed tomography, both the total size including ground-glass opacities and the solid size alone were measured. To calculate the rates of lymph node metastasis by the tumor size, the tumors were divided into six groups by their sizes: 5 mm or less, 6 to 10 mm, 11 to 15 mm, 16 to 20 mm, 21 to 25 mm, and 26 to 30 mm.The average numbers of dissected lymph nodes and dissected lymph node stations were 17 and 5, respectively. Seventy-five patients (18%) were postoperatively discovered to have positive nodes. The rates of node metastasis in each total size group were 0/1 (0%), 0/29 (0%), 5/77 (7%), 17/121 (14%), 27/101 (27%), and 26/84 (31%), respectively. The rates of node metastasis in each solid size group were 0/37 (0%), 1/53 (2%), 9/88 (10%), 17/104 (16%), 23/78 (30%), and 25/53 (47%), respectively. The area under the curve of receiver operating characteristic curves for the total size was measured as 0.701, and that for the solid size was measured as 0.777. By multivariate analysis, solid size, maximum standardized uptake value, and lymphovascular invasion were independent significant predictive factors.Solid size, maximum standardized uptake value, and lymphovascular invasion were independent predictors for lymph node metastasis of lung adenocarcinoma. The size of the solid component explained the relation between the tumor size and the lymph node metastasis more accurately than that explained by the total tumor size on high-resolution computed tomography.
Baij Nath Bhandari
Authors: R. Gaind
Journal: BMJ (2003)

Former physician New Delhi (b 1906; q Durham 1930; MD, MRCP, DTM), d 21 May 2003.

Major general Baij Nath Bhandari had an illustrious career with the Indian Army Medical Corps, from which he retired as a deputy director of medical services. He was one time principal of Maulana Azad Medical College and medical director of Irwin Hospital, New Delhi. In the second part of his life he dedicated himself to the poorest of the poor in the bastis (slums) of New Delhi, providing free primary health care services. He became closely involved with the Arpana charity, which works to empower poor people in the villages of India. His translation of the Bhagavad Gita from Hindi into English is a reflection of his good understanding of Hindi and Sanskrit and was well received. He leaves a wife, Kamla, and two daughters.
THE TREATMENT OF EPIDEMIC CEREBRO-SPINAL MENINGITIS
Authors: G. C. Low
Journal: BMJ (1915)

IFEB 27 I9rg cough and nio oetpe-toratl'on.Ani effective pneumothorax bas enablel tllis soldlier, wlho a few years ago Aas attacked with tuberculosis, to takve part in a campaigni for a mlontl niuider extL'einy ti'ving circuImstances, and it still finds hiiii in excellent liealtlh after such experioelce.At the fronit tuberculous soldiers are not found in thle linie of tlie Allies alone.Tlley are just as nuiuerouls, if nlot mtiore so, amilonlg tlle Geirmans.InI tlhe TiMC8 of Februiary 13tl' Ey6-Witness," whlo is at present withi 'General Head Quartelrs, in' describing operations at La Bassee, says:It lhas alreafly beenii miienitioned that some of the prisoners captured by uis lately-hav-e been of comparatively poor physique.In tOis coiinexioni it is interesting to note that during the last few dlays a dead Germana was founid having two metlical certi- ficate8 in hiis pocket statiln that lie was suffering from con- suimption.They are hoth signed by a doctor and are accom- panied by ani application from the father that his son should niot be senlt oni active service as he was suLfferinig from lung trouble.
Rapid Migration of<sup>111</sup>Indium-Labeled Granulocytes to Sites of Infection
Authors: Janice P. Dutcher, Charles A. Schiffer, Gerald S. Johnston
Journal: New England Journal of Medicine (1981)

ISOTOPIC labels attached to various blood cells have been used for years to study the course and kinetics of blood components in vivo. The use of such labeling in granulocytes to evaluate transfusions or to localize infections has met with uncertain success.1 2 3 4 5 6 7 Recently, 111In combined with the chelating agent 8-hydroxyquinoline (oxine) has been used in granulocyte-labeling research.8 9 10 The advantages of 111In include tight cytoplasmic binding with minimal in vivo elution and preservation of cell viability and function after the granulocytes are exposed to the isotope.11 In addition, the energy spectrum of this element consists of two peaks at 173 and . . .
Preferential mRNA expression of prostromelysin relative to procollagenase and in situ localization in human articular cartilage.
Authors: Q Nguyen, J S Mort, P J Roughley
Journal: Journal of Clinical Investigation (1992)

An imbalance between extracellular proteinases and their inhibitors is thought to underlie cartilage degradation. In cultures of adult cartilage, prostromelysin mRNA levels were much higher than those for procollagenase and this differential was increased in cultures stimulated with IL-1 beta. Analysis of mRNA prepared from freshly isolated chondrocytes showed abundant amounts of prostromelysin mRNA in normal adult cartilage but low levels in the neonate. Not all adult cartilage may possess such high levels of prostromelysin mRNA, as the message levels in the cartilage remaining on late-stage osteoarthritic joints were lower than those in normal adult cartilage. Relative to prostromelysin mRNA, little procollagenase and TIMP mRNA were found in the adult cartilage. In situ hybridization revealed that metalloproteinase mRNAs were localized in chondrocytes of the superficial zone in adult cartilage. However, upon IL-1 beta treatment, chondrocytes in all cartilage zones were observed to express prostromelysin mRNA. Relative to the neonate, the normal adult cartilage appears to have a high degradative potential, if one accepts that steady-state mRNA levels reflect prostromelysin production. As the adult cartilage is not apparently undergoing rapid turnover, it would appear that control of prostromelysin activation may be the major regulatory step in stromelysin-induced cartilage degradation.
Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis
Authors: Yu-Chang B. Wu, Louisa K. James, Jason A. Vander Heiden, Mohamed Uduman, Stephen R. Durham, Steven H. Kleinstein, David Kipling, Hannah J. Gould
Journal: Journal of Allergy and Clinical Immunology (2014)

Previous studies of immunoglobulin gene sequences in patients with allergic diseases using low-throughput Sanger sequencing have limited the analytic depth for characterization of IgE repertoires.We used a high-throughput, next-generation sequencing approach to characterize immunoglobulin heavy-chain gene (IGH) repertoires in patients with seasonal allergic rhinitis (AR) with the aim of better understanding the underlying disease mechanisms.IGH sequences in matched peripheral blood and nasal biopsy specimens from nonallergic healthy control subjects (n = 3) and patients with grass pollen-related AR taken in season (n = 3) or out of season (n = 4) were amplified and pyrosequenced on the 454 GS FLX+ System.A total of 97,610 IGH (including 8,135 IgE) sequences were analyzed. Use of immunoglobulin heavy-chain variable region gene families 1 (IGHV1) and 5 (IGHV5) was higher in IgE clonotypic repertoires compared with other antibody classes independent of atopic status. IgE repertoires measured inside the grass pollen season were more diverse and more mutated (particularly in the biopsy specimens) and had more evidence of antigen-driven selection compared with those taken outside of the pollen season or from healthy control subjects. Clonal relatedness was observed for IgE between the blood and nasal biopsy specimens. Furthermore in patients with AR, but not healthy control subjects, we found clonal relatedness between IgE and IgG classes.This is the first report that exploits next-generation sequencing to determine local and peripheral blood IGH repertoires in patients with respiratory allergic disease. We demonstrate that natural pollen exposure was associated with changes in IgE repertoires that were suggestive of ongoing germinal center reactions. Furthermore, these changes were more often apparent in nasal biopsy specimens compared with peripheral blood and in patients with AR compared with healthy control subjects.
CLINICAL ASPECTS OF HYPERTENSION
Authors: JOSEPH L. MILLER
Journal: JAMA (1913)

While the question of hypertension has been thoroughly discussed during recent years, it is still one of the problems in medicine. With the introduction and general use of the sphygmomanometer, we have become acquainted with the frequency of increased blood-pressure, and have been able to follow its course; but the question of its etiology or pathologic physiology is largely undetermined. The present report is concerned merely with the present views of its etiology, a consideration of a series of cases observed during the past few years, and a brief discussion of the prognosis and treatment. Arterial and renal changes have always been considered the most important factors in high blood-pressure. With our increasing knowledge of this subject, the importance of the renal factor has become more and more apparent, and coincidentally with this, lessened weight is attached to general arterial changes, especially if we exclude the arterial changes in the
Abstract 4075: Regulation of NKX3.1 by RMND5 proteins.
Authors: Alison Louw, Marc A. Thomas, Jennet Harvey, Jacqueline M. Bentel
Journal: Cancer Research (2013)

Abstract Expression of the prostatic tumour suppressor, NKX3.1 is reduced or undetectable in a large proportion of advanced human prostate tumours. Although loss of heterozygosity (LOH) is common at the 8p21.2 locus which encompasses the NKX3.1 gene, mutations of the remaining NKX3.1 allele that would account for loss of NKX3.1 expression have not been identified. Indeed, the documented discordance between NKX3.1 mRNA and protein expression suggests that translational or posttranslational mechanisms contribute to the loss of NKX3.1 expression in prostate tumour tissues. We have identified two novel NKX3.1 binding proteins in LNCaP cells, RMND5A and RMND5B. The RMND5A gene locus at 2p11.1 is deleted or amplified in a variety of cancers, while the RMND5B locus at 5q35.3 undergoes frequent LOH in breast tumours from BRCA1 and BRCA2 mutation carriers and is located within an uncharacterised prostate cancer heritability locus. RMND5 proteins are widely expressed, multidomain proteins that each contain a putative RING domain, suggesting that they are able to function as E3 ubiquitin ligases. In in vitro ubiquitin assays, the RING domain of RMND5A was able to associate with UbcH2, UbcH5b and UbcH5c, while the RING domain of RMND5B interacted with UbcH5b and UbcH5c to mediate ubiquitin transfer. Both RMND5A and RMND5B were associated with ubiquitinated proteins in vivo and the increased expression of RMND5A or RMND5B augmented cellular levels of ubiquitinated proteins, providing further evidence of their E3 ubiquitin ligase activity. Overexpression of either RMND5A or RMND5B in LNCaP cells resulted in dose-dependent declines in endogenous NKX3.1 levels, which were attenuated following proteasome inhibition. In addition, RMND5A or RMND5B overexpression enhanced cellular levels of ubiquitinated NKX3.1. In LNCaP cells, RMND5 proteins were diffusely distributed in the cytoplasm and nucleus, with RMND5B occasionally exhibiting a punctate cytoplasmic distribution. When NKX3.1 and RMND5A or RMND5B were overexpressed, RMND5 proteins became predominantly nuclear, while the nuclear levels of NKX3.1 were markedly reduced. Together, these findings indicate that RMND5 proteins promote NKX3.1 ubiquitination and proteasome-dependent degradation and additionally modify the intracellular localisation of NKX3.1, potentially regulating its function as a transcription factor. Citation Format: Alison Louw, Marc A. Thomas, Jennet Harvey, Jacqueline M. Bentel. Regulation of NKX3.1 by RMND5 proteins. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4075. doi:10.1158/1538-7445.AM2013-4075