Intravascular Hemolysis in a Patient with Valvular Heart Disease
Authors: DONALD S. MILLER
Journal: Annals of Internal Medicine (1966)

Article1 August 1966Intravascular Hemolysis in a Patient with Valvular Heart DiseaseDONALD S. MILLER, M.D., CHARLES E. MENGEL, M.D., WILLIAM B. KREMER, M.D., JORDAN GUTTERMAN, M.D., RON SENNINGENDONALD S. MILLER, M.D., CHARLES E. MENGEL, M.D., WILLIAM B. KREMER, M.D., JORDAN GUTTERMAN, M.D., RON SENNINGENAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-210 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe in vivo role of mechanical factors as a cause of increased destruction of red blood cells has received greater attention recently. This phenomenon was implied by Brain, Dacie, and Hourihane (1) in their studies of patients with bizarre red cells in the setting of small blood vessel disease and the term "microangiopathic hemolytic anemia" was coined. Mechanical factors were also thought to play a role in the hemolysis that has been reported after the implantation of aortic valve prosthesis (2-4). Recently, it has been suggested that damaged, distorted valves, and the accompanying hemodynamic alterations, per se, may cause unusual...References1. BRAINDACIEHOURIHANE MCJVDO: Microangiopathic haemolytic anaemia: the possible role of vascular lesions in the pathogenesis. Brit. J. Haemet. 8: 358, 1962. CrossrefMedlineGoogle Scholar2. STOHLMANSARNOFFCASENESS FSJRBAT: Hemolytic syndrome following the insertion of a lucite ball valve prosthesis into the cardiovascular system. Circulation 13: 586, 1956. CrossrefMedlineGoogle Scholar3. STEVENSONBAKER TDHJ: Hemolytic anemia following insertion of a Starr-Edwards valve prosthesis. Lancet 2: 982, 1964. CrossrefMedlineGoogle Scholar4. MARSH GW: Intravascular hemolytic anemia after aortic valve replacement. Ibid., p. 986. Google Scholar5. 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MENGELKANNO'MALLEY CEHEBW: Increased hemolysis after intramuscular iron administration in patients with paroxysmal nocturnal hemoglobinuria. Blood 26: 74, 1965. CrossrefMedlineGoogle Scholar25. REYNOLDSCOLTMANROBERTS RDCADK: Sideropenic intravascular hemolysis due to prosthetic valve insufficiency. Clin. Res. 13: 281, 1965. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North Carolina, and Columbus, OhioFrom the Departments of Medicine, Duke University, Durham, N. C., and The Ohio State University, Columbus, Ohio.This work was supported by grants CA-06452-04 and CA-08170-01, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Charles E. Mengel, M.D., Director, Division of Hematology, Ohio State University, 410 W. 10th Ave., Columbus, Ohio 43210. 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