tbuckley/cabot-search huggingface dataset:
A dark side near you
Authors: C. Essex
Journal: BMJ (1995)

Once Were Warriors has overtaken Jurassic Park as the highest earning film ever in New Zealand. Why has a film that paints a dismal picture of some people's existence in the 1990s, of a bleak urban landscape of children and dogs roaming the streets and rusting cars on waste lots, been sold to over 20 countries and won awards in Montreal and praise at other major film festivals?

Jake and Beth Heke are a Maori couple living in South Auckland, New Zealand, with few opportunities and little hope. Their story could be set in any city or town anywhere in the world—you just have to look on the wrong side of the tracks to find them. Beth is trying to hold the family together despite her five children all hating …
Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase
Authors: Ayano Fukuhara, Hidemitsu Nakajima, Yuya Miyamoto, Katsuaki Inoue, Satoshi Kume, Young-Ho Lee, Masanori Noda, Susumu Uchiyama, Shigeru Shimamoto, Shigenori Nishimura, Tadayasu Ohkubo, Yuji Goto, Tadayoshi Takeuchi, Takashi Inui
Journal: Journal of Controlled Release (2011)
Preliminary Study on the Evaluation of Olfactory Neuroblastoma Using PET/CT
Authors: Hu-bing Wu, Quan-shi Wang, Jin-mei Zhong, Wen-lan Zhou, Hong-sheng Li, Wang Qiao-yu
Journal: Clinical Nuclear Medicine (2011)

Because of paucity of data available regarding the utility of PET/CT in the diagnosis and staging of patients with olfactory neuroblastoma (ONB), we retrospectively analyzed the efficacy of PET/CT in 9 patients with ONB.Whole-body F-18 FDG PET/CT was performed in 7 patients with newly diagnosed ONB, as well as in 1 patient with recurrence and in 1 patient with remnant tumor. Regional C-11 choline (C-11 CHO) PET/CT was performed in 2 patients with negative F-18 FDG scans. The lesion with intense radiotracer uptake was suggested as positive for tumor and the results of PET/CT were compared with conventional staging examinations.F-18 FDG PET/CT was positive in 7/9 (77.7%) patients with ONB. In 2 patients with negative F-18 FDG, the lesions were C-11CHO avid. Both the primary tumors and its invasions were clearly delineated by F-18 FDG or C-11 CHO PET/CT. SUVmax of F-18 FDG in the primary tumor was 6.37 ± 4.22 and did not correlate with lesion size (F-18 FDG/size: r = 0.097, P = 0.820). Whole-body F-18 FDG PET/CT detected parapharyngeal and cervical lymph node metastases in 2 patients, lung metastases in 1 patient, liver metastases in 1 patients, and bone metastases in 2 patients. PET/CT altered the stages of 3 of 9 patients with upstaging in 2 patients and downstaging in 1 patient.PET/CT may be useful for the diagnosis and staging of ONB.
Cultivation in Vitro of Frozen and Desiccated Mouse Tumour Tissues
Authors: R. D. Passey, L. Dmochowski, I. Lasnitzki, A. Millard
Journal: BMJ (1950)

B considers, as we do, that the surviving cells are responsible for the tumours induced with frozen-dried material.Apparently Gye et al. made no attempt to look for a virus with the electron microscope, which in these days is perhaps the method par excellence for the detection of viruses.For what the observation is worth, we have found that such tumours as have been examined in low-cancer strains, whether induced or spontaneous, are free of any virus-like particles under the electron microscope, whereas in high-breast-cancer strains the electron microscope has consistently revealed the presence of particulate matter mainly of some 250 A (Passey, Dmochowski, Astbury, and Reed, 1947; Passey, Dmochowski, Astbury, Reed, and Johnson, 1948, 1950; Passey, Dmochowski, Reed, and Astbury, 1950), which is always associated with the Bittner agent.To sum up: first, in none of our centrifuge experiments were tumours induced with clear supernatants free from cells, while with few exceptions the sediments, in which apparently intact cells were always to be found, regularly induced tumours, which is clear evidence that the tumour- inducing activity was always associated with the tumour cell, and was not separable from it; secondly, the micro- scopical evidence provides further support for the belief that some of the cells had survived, in that, after the various treatments of freezing and freeze-drying, many intact cells were to be found which in appearance were very little different from the untreated minced material.It seems to us, in view of the available evidence, that there is no need to invoke a virus as the active agent.It must, however, be admitted that a final decision on whether the cells are viable and are responsible for the results can be reached only after an attempt to grow tumour cells in vitro after freeze-drying.Experiments along these lines have been carried out in this department in collaboration with Dr. I. Lasnitzki, from the Strangeways Labora- tory, Cambridge.The results of these experiments are reported in the paper which immediately follows this communication. Summary and ConclusionsMinced tumours, both sarcomata and carcinomata, retain their power to induce fresh tumours after freezing and subse- quent desiccation under the experimental conditions described by Gye et al.Centrifugation at slow speeds of tumour tissues similarly treated, together with our histological studies, indicates that living cells, and not a virus, are responsible for the results.We should like to express our thanks and appreciation to Mr. W. Blackledge, in charge of the photography department of Leeds University, for his help and great care in taking photographs of the histological specimens.We also wish to acknowledge the help given by Mr. Kenneth Morton in the preparation and staining of the histological specimens.
Salmonid sexual development is not consistently altered by embryonic exposure to endocrine-active chemicals.
Authors: D B Carlson, L R Curtis, D E Williams
Journal: Environmental Health Perspectives (2000)

Fish sexual development is sensitive to exogenous hormone manipulation, and salmonids have been used extensively as environmental sentinels and models for biomedical research. We simulated maternal transfer of contaminants by microinjecting rainbow trout (Oncorhynchus mykiss) and chinook salmon (Oncorhynchus tshawytscha) embryos. Fish were reared for 6 months and sexed, and gonads were removed for histology and measurement of in vitro steroid production. Analysis of fat samples showed that dichlorodiphenylethylene (DDE) levels, o, p'M-DDE and p,o, p'-DDE isomers, were elevated 6 months after treatment. A preliminary study showed an increased ratio of males to females after treatment with 80 mg/kg and 160 mg/kg of the xenoestrogen o,o, p'-DDE. One fish treated with 160 mg/kg o,o, p'-DDE had gonads with cells typical of both males and females. A follow-up study, using more fish and excluding the highly toxic 160 mg/kg o,o, p'-DDE dose, showed no effect on sex ratio or gonadal histology. Embryonic exposure of monosex male trout, monosex female trout, and mixed sex salmon to o, o, p'-DDE, p,o, p'-DDE, mixtures of DDE isomers, and octylphenol failed to alter sexual development. We observed no treatment-dependent changes in in vitro gonadal steroid production in any experiments. Trout exposed in ovo and reared to maturity spawned successfully. These results suggest that mortality attributable to the xenoestrogens o,o, p'-DDE, chlordecone, and octylphenol, and the antiandrogen p,o, p'-DDE, is likely to occur before the appearance of subtle changes in sexual development. Because trout appeared to be sensitive to endocrine disruption, we cannot dismiss the threat of heavily contaminated sites or complex mixtures to normal sexual development of salmonids or other aquatic organisms.
Mapping the Atrioventricular Node
Authors: Andrew E Epstein, James K Kirklin
Journal: New England Journal of Medicine (2007)

A 75-year-old woman presented with dyspnea, an awareness of rapid heart action, and permanent atrial fibrillation with a rapid ventricular response that had been resistant to treatment with beta-blockers, calcium-channel blockers, digoxin, and multiple cardioversions. For severe rheumatic aortic and mitral stenosis, she had undergone replacement of the aortic and mitral valves with Starr–Edwards devices in 1970, as seen on chest radiography on admission (Panels A and B, arrows). In 2006, a pacemaker had been implanted for the treatment of bradycardia. To control the rapid ventricular response to atrial fibrillation, the patient underwent ablation of the atrioventricular node, located just . . .
Autonomic neuropathy in rheumatoid arthritis.
Authors: M E Edmonds, T C Jones, W A Saunders, R D Sturrock
Journal: BMJ (1979)

Patients with seropositive and seronegative rheumatoid arthritis (RA) and age-matched controls were investigated for the presence of autonomic neuropathy. Significantly more patients with RA had abnormal autonomic function, suggesting that autonomic neuropathy occurs more commonly in RA than hitherto suspected. The existence of an autonomic neuropathy may be an important complicating factor in rheumatoid disease and may lead to increased morbidity and mortality.
Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment
Authors: Takuji Yamauchi, Katsuto Takenaka, Shingo Urata, Takahiro Shima, Yoshikane Kikushige, Takahito Tokuyama, Chika Iwamoto, Mariko Nishihara, Hiromi Iwasaki, Toshihiro Miyamoto, Nakayuki Honma, Miki Nakao, Takashi Matozaki, Koichi Akashi
Journal: Blood (2013)
The Role of Ga-67 Whole-Body and Tc-99m DMSA Renal Scan in Primary Bilateral B-Cell Renal Non-Hodgkin's Lymphoma
Authors: TZU-CHEN YEN, KAI-YUAN TZEN, KUN-JU LIN
Journal: Clinical Nuclear Medicine (1999)

Ga-67 is an important tool for detecting non-Hodgkin's lymphoma lesions. Tc-99m DMSA is used widely to evaluate the viability of renal cortical cells. The authors describe a patient who had bilateral renal non-Hodgkin's lymphoma. He had a similar uptake pattern on Ga-67 and Tc-99m DMSA renal imaging before treatment. In addition, increased Ga-67 accumulation in the upper shaft of the left femur was also noted. After chemotherapy, the lesions seen with Ga-67 and Tc-99m DMSA were resolved almost completely.
Abstract 5469: SAR650984, an anti-CD38 antibody, shows anti-tumor activity in a preclinical model of multiple myeloma.
Authors: Byron Hann, Ti Cai, Donghui Wang, Yun-Kit Hom, Blake T. Aftab, Tom Martin, Jeffrey Wolf
Journal: Cancer Research (2013)

Abstract Multiple myeloma (MM) is the second most common cancer of the blood and one that is difficult to treat. Although survival has greatly improved over the past decade, MM remains fatal, necessitating development of novel therapies. CD38 is a promising target for antibody therapeutics for the treatment MM and various other hematological malignancies. CD38 is a type II transmembrane glycoprotein with ectozyme activity that has been implicated in Ca2+ mobilization and is found highly expressed on malignant plasma cells of MM. CD38 expression correlates with poor disease prognosis in a subset of hematological malignancies, including MM, where CD38 expression in circulating cells is associated with decreased progression free survival. Previous studies have identified several potential mechanisms of action in the context of anti-myeloma activity, including antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and pro-apoptotic activity in cancer cell lines. To determine the potential therapeutic value of targeting CD38 in the context of MM, a humanized anti-CD38 antibody, SAR650984, was generated and evaluated for anti-tumor activity. We evaluated anti-tumor activity of SAR650984 in xenograft-based models of multiple myeloma . SAR650984 demonstrated potent anti-tumor activity in NCI-H929 and RPMI-8226 MM xenograft models. These results strongly support continued clinical examination of the therapeutic potential for SAR650984 in the treatment of MM and further demonstrates that targeting CD38 with SAR650984 has potential to impact MM disease. Citation Format: Byron Hann, Ti Cai, Donghui Wang, Yun-Kit Hom, Blake T. Aftab, Tom Martin, Jeffrey Wolf. SAR650984, an anti-CD38 antibody, shows anti-tumor activity in a preclinical model of multiple myeloma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5469. doi:10.1158/1538-7445.AM2013-5469
Hereditary Nephropathy, Deafness, and Renal Foam Cells.
Authors: R. E. Whalen
Journal: Annals of Internal Medicine (1961)

s1 May 1961Hereditary Nephropathy, Deafness, and Renal Foam Cells.R. E. Whalen, M.D., S. Huang, M.D., E. Peschel, M.D., H. D. McIntosh, M.D., (Assoc.)R. E. Whalen, M.D.Search for more papers by this author, S. Huang, M.D.Search for more papers by this author, E. Peschel, M.D.Search for more papers by this author, H. D. McIntosh, M.D., (Assoc.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1064_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of renal disease and nerve deafness is now a well-recognized clinical entity. The hereditary nature of the deafness and renal disease, the increased severity of renal disease in males, and the occasional occurrence of ocular defects have been confirmed in over 20 families throughout the world. Whether the basic renal lesion is chronic pyelonephritis or glomerulonephritis remains to be elucidated. In three families large numbers of foam cells have been present in the kidneys.The present report describes a family with hereditary nephropathy and deafness, and reviews some of the unusual pathologic features of the syndrome. Examination of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1064-1064KeywordsCellsDeafnessGlomerulonephritisKidneysLesionsNervesPyelonephritisRenal diseases Issue Published: 1 May 1961 PDF downloadLoading ...
Paying the Physician's Fee
Authors: Thomas L. Delbanco, Katherine C. Meyers, Elliot A. Segal
Journal: New England Journal of Medicine (1979)

At a time of debate over physicians' fees and income, we describe the evolution of Blue Shield plans and programs to pay physicians' fees. We review how Medicare's "reasonable-charge" formulas fostered Blue Shield "usual, customary, and reasonable" (UCR) contracts. In a three-year period in the Washington, DC, area, Blue Shield UCR protocols permitted "customary" allowances for selected surgical procedures to rise 29 to 75 per cent; charges by two physicians increased allowances for coronary-artery bypass from $2000 to $3500. We find little justification for secrecy in fee-payment protocols. Physicians dominate the District of Columbia Blue Shield Board and its committees, and they control fee-payment formulas. Nationally, 61 per cent of Blue Shield boards have majorities of health-care providers; approximately two thirds of fee-related committees have physician majorities. We urge increased public debate, public representation, and accountability in monitoring and reforming the programs that we describe.
Older Age and a Reduced Likelihood of 2009 H1N1 Virus Infection
Authors: David N. Fisman, Rachel Savage, Jonathan Gubbay, Camille Achonu, Holy Akwar, David J. Farrell, Natasha S. Crowcroft, Phil Jackson
Journal: New England Journal of Medicine (2009)

Among persons who were at risk for infection with 2009 H1N1 virus, being born before 1957 was associated with a lower infection risk.
Abstract 1204: Establishment of a patient-derived orthotopic xenograft (PDOX) model of patient cervical cancer
Authors: Yukihiko Hiroshima, Yong Zhang, Ali Maawy, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Ali Maawy, Itaru Endo, Robert M. Hoffman
Journal: Cancer Research (2014)

Abstract We implanted a tumor resected from a patient with metastatic HER-2-positive cervical cancer from 8 NOD/SCID mice (F1; NOD/SCID-sc) and 10 nude mice (F1; Nude-sc) subcutaneously, and 8 nude mice (F1; Nude-soi) orthotopically. Five out of 8 NOD/SCID mice died within 7 days after implantation. Infections around the surgical wound, loss of weight and of lethargy were observed in post-operatively in other mice. We examined the tumor-take rate of each model 8 weeks after implantation. Tumors grew in 3 out of 3 mice in F1; NOD/SCID-sc (100 %); 7 out of 10 mice in F1; nude-sc (70 %) and 6 out of 8 mice in F1; nude-soi group (75 %), respectively. The metastatic tumors (peritoneal dissemination, liver metastasis, lung metastasis or lymph node metastasis) were detected in 4 mice in F1; nude-soi mice (50 %). We found all xenografts including the metastatic tumors had histological structures similar to the original tumor and were stained by anti-human HER-2 antibody. Next, we implanted the small fragments of subcutaneous tumors from F1; Nude-sc mice (F2; sc-sc) or the primary tumors of F1; nude-soi mice (F2; soi-sc) to another set of nude mice (20 mice each) subcutaneously, and examined the tumor-take rate of each group 4 weeks and 8 weeks after implantation. Eight mice in the F2; sc-sc group (40 %) and 16 mice in the F2; soi-sc group (80 %) had tumors at week 4, and 15 mice in the F2; sc-sc group (75 %) and 19 mice in the F2; soi-sc group (95 %) had tumors at week 8. These results suggest that PDOX in nude mouse model recapitulates the biological behaviors of the original tumor and has the sufficient tumor-take rate. Citation Format: Yukihiko Hiroshima, Yong Zhang, Ali Maawy, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Ali Maawy, Itaru Endo, Robert M. Hoffman. Establishment of a patient-derived orthotopic xenograft (PDOX) model of patient cervical cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1204. doi:10.1158/1538-7445.AM2014-1204
Blood sugar measurement by dextrostix reflectance meter method.
Authors: P Bottermann, T Zilker
Journal: BMJ (1972)

thyroxine 0.1 uig/100 ml, total fats 1,820 mg/100 ml, cholesterol 523 mg/100 ml, urea 516 mg/100 ml, creatinine 6.6 mg/100 ml, and uric acid 17 mg/100 ml.The glomerular filtration rate measured by creatinine clearance was 7 ml/min.The bladder was drained by an indwelling catheter and the patient was given triiodothyronine.After 10 days she recovered bladder control, the urea was 80 mg/ 100 ml, and the creatinine clearance 25 ml/min.The electroencephalogram became normal.After four months the urea was 42 mg/ 100 ml and the creatinine clearance 82 ml/min, and the patient was well in herself.Though myxoedema has been shown clinically and experimentally to cause weak- ness of the bladder muscle' we have not found any reports in the literature of renal failure occurring, as in our case.Retention of urine must now be included among the various clinical forms in which myxoedema presents itself.-Weare, etc.,
Remarks on Phthisical Insanity
Authors: S. W. D. Williams
Journal: BMJ (1865)

sist of granular masses of fibrine, with cylinders, and broken up epithelium which has been tlrown of,, and subsequently washed from the tubes by the urine.In the acute disease, the epithelium is generally entire; while, in the chronic form, the cells are clisintegrated and granular, and free from the bloodcorpuscles which frecluently obtain in the former va- riety.
Accelerated endothelial wound healing on microstructured substrates under flow
Authors: Davide Franco, Florian Milde, Mirko Klingauf, Fabrizio Orsenigo, Elisabetta Dejana, Dimos Poulikakos, Marco Cecchini, Petros Koumoutsakos, Aldo Ferrari, Vartan Kurtcuoglu
Journal: Biomaterials (2012)
THE SYMPATHETIC NERVOUS SYSTEM AND THE "IRRITABLE HEART OF SOLDIERS."
Authors: F. Fraser, R. M. Wilson
Journal: BMJ (1918)

In my opinion it will be necessary for general practi- tioners to specialize to some extent in the future, and then by team work, either in partnerships or some other way convenient to all, to enable mutual work to be done amongst and for ourselves, and to the great advantage of our patients.Cannot general practitioners do something themselves to promote this pooling of clinical work?Before we can move to any advantage we must throw oierboard one fetish-namely, the all-sufficiency of the individual practitioner.Such a claim might be set up for a Boerhaave, but it is frankly impossible ii our day.This
Blood and brain concentrations of mercaptans in hepatic and methanethiol induced coma.
Authors: H Al Mardini, K Bartlett, C O Record
Journal: Gut (1984)

It has been suggested that mercaptans are important factors in the pathogenesis of hepatic encephalopathy. Using a gas liquid chromatographic technique which uses propanethiol as internal standard and a sulphur specific detector, blood methanethiol concentration was found to be significantly risen in encephalopathic patients with liver disease (13.2 +/- 1.0 nmol/ml; n = 47) compared with control subjects (5.7 +/- 0.3, n = 29; p less than 0.05) and non-encephalopathic patients with liver disease (7.7 +/- 1.1, n = 35; p less than 0.05) but ethanethiol and dimethylsulphide concentrations were similar in the three groups. Blood methanethiol, however, was not clearly related to coma grade, similar values being found in deeply comatosed patients to those showing only mild cerebral dysfunction. When rats were injected with 40-120 mumol methanethiol a range of responses was obtained which varied between normal consciousness and coma. The minimum blood concentration of methanethiol associated with coma (200 nmol/ml) was at least 10-fold greater than in patients with hepatic encephalopathy but brain concentrations were similar in comatose rats and those which remained awake. Blood methanethiol concentrations were similar in control and germ free rats and did not rise in cirrhotics or controls after ingestion of 2 g methionine. It is concluded that while methanethiol may accumulate in hepatic coma, it is unlikely to be of major pathogenetic importance. Endogenous mercaptans are unlikely to originate from bacterial metabolism in the gut.
Computer Recording of Automobile Accident Data
Authors: Paul H. Blachly
Journal: JAMA (1966)

To the Editor:—  I hope thatThe Journalwill continue to publish such excellent reports on the prevention of automobile accidents as the recent ones by Buxbaum and Colton and by Charles and States.  With present-day computer facilities it is feasible to consider recording and reporting every single accident due to mechanical failures and relate this to the year, make and model of automobile. When a significant trend appears, a particular defect in any model (that conceivably could show up only two or three years after purchase of the car), public health agencies, using computer techniques, could automatically (with cooperation from state motor vehicle departments) notify every owner of that particular make and model of the defect. The public health agencies make continuing notes of dangers due to new models of viruses and bacteria. It is logical that they should do the same for the vastly more dangerous automobile.