tbuckley/cabot-search huggingface dataset:
Positron Emission Tomography in Primary Thyroid Lymphoma
Authors: Subhash Chander, Alkis P. Zingas, David A. Bloom, Imad T. Zak, Richard N. Joyrich, Todd M. Getzen
Journal: Clinical Nuclear Medicine (2004)

F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) has proven to be useful in the staging, restaging, and assessment of response to treatment in non-Hodgkin lymphoma and Hodgkin disease. Primary thyroid lymphoma is a rare thyroid tumor that usually occurs in elderly women. The authors describe a patient with primary thyroid lymphoma that demonstrated significant increased FDG uptake in the thyroid gland and a lymph node in the left side of the neck.
Pulmonary and generalized lysosomal storage induced by amphiphilic drugs.
Authors: Z Hruban
Journal: Environmental Health Perspectives (1984)

Administration of amphiphilic drugs to experimental animals causes formation of myelinoid bodies in many cell types, accumulation of foamy macrophages in pulmonary alveoli and pulmonary alveolar proteinosis. These changes are the result of an interaction between the drugs and phospholipids which leads to an alteration in physicochemical properties of the phospholipids. Impairment of the digestion of altered pulmonary secretions in phagosomes of macrophages results in accumulation of foam cells in pulmonary alveoli. Impairment of the metabolism of altered phospholipids removed by autophagy induces an accumulation of myelinoid bodies. The administration of amphiphilic compounds thus causes pulmonary intra-alveolar histiocytosis which is a part of a drug-induced lysosomal storage or generalized lipidosis. The accumulation of drug-lipid complexes in myelinoid bodies and in pulmonary foam cells may lead to alteration of cellular functioning and to clinical disease. Currently over 50 amphiphilic drugs are known. Unique pharmacological properties necessitate clinical use of some of these drugs. The occurrence and severity of potential clinical side effects depend on the nature of each drug, dosage and duration of treatment, simultaneous administration of other drugs and foods, individual metabolic pattern of the patient and other factors. Further studies on factors preventing and potentiating adverse effects of amphiphilic drugs are indicated.
Measurement and Significance of Cancellation Potentials on the Human Subject
Authors: ERNEST FRANK
Journal: Circulation (1955)

A versatile four-electrode single-channel system is described which is useful for precise research measurements of mirror patterns on the intact human subject, and the theoretic significance of results obtained on normal subjects for the QRS complex is presented in detail. It is concluded that the QRS complex at all points on the body of normal human subjects, including the precordium, can be considered to arise from a fixed-location equivalent heart dipole to an average accuracy of 5 per cent. Therefore, the "proximity" potential concept is untenable for the normal QRS complex.
Anthropology and Primary Health Care
Authors: Thomas H. Lewis
Journal: JAMA (1992)

Planning toward providing primary health care to all the world is, without argument, admirable in its humanistic vision. It calls for the finest of human effort and ingenuity. It is a goal not yet accomplished even in the wealthy industrial nations. The exertions that will be required, the funds and workers not yet recruited, and the infinitely detailed operational issues make the labors assigned to Hercules seem the wispiest of trivia. The magnitude and variety of organizational problems seem now to have set the laborers in the field to attacks upon each other. This book, which airs their weariness and frustration, seems to be intended for consumption within the World Health Organization bureaucracy. A physician (for the purposes of review in a medical journal) might pick up this softcover book of 14 essays prepared to learn about primary medical care and the social sciences, but put it down somewhat shaken,
Four millimetres: a variable measurement?
Authors: E.M. Wain, C.M. Stefanato
Journal: British Journal of Dermatology (2007)

Journal Article Four millimetres: a variable measurement? Get access E.M. Wain, E.M. Wain St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K. E‐mail: marywain@doctors.net.uk Search for other works by this author on: Oxford Academic Google Scholar C.M. Stefanato C.M. Stefanato St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K. E‐mail: marywain@doctors.net.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 2, 1 February 2007, Page 404, https://doi.org/10.1111/j.1365-2133.2006.07663.x Published: 01 February 2007
Risk of Hepatitis B Virus Reactivation in Patients Who Are Hepatitis B Surface Antigen Negative/Antibody to Hepatitis B Core Antigen Positive and the Role of Routine Antiviral Prophylaxis
Authors: Yu Xuan Koo, Daniel S.W. Tan, Bee Huat Tan, Richard Quek, Miriam Tao, Soon Thye Lim
Journal: Journal of Clinical Oncology (2009)

cancer agents can be significantly enhanced by aiming for a tailored treatment of both the tumor and the cardiovascular comorbidites.Therefore, the involvement of cardiologists in the treatment of cancer patients seems crucial.
Plasma fibronectin in Crohn's disease.
Authors: A Allan, J Wyke, R N Allan, P Morel, M Robinson, D L Scott, J Alexander-Williams
Journal: Gut (1989)

The hypothesis that abnormal fibronectin metabolism in Crohn9s disease could be an important mechanism leading to stricture formation or postoperative infection was tested in three related studies. (1) Lower concentrations of plasma fibronectin (p less than 0.05) were found in 20 patients with small and large bowel Crohn9s disease (mean 0.24 g/l) compared with 13 patients with more limited disease confined to only small or only large bowel (mean 0.27 g/l) or 20 healthy controls (mean 0.29 g/l). (2) In 25 patients followed for 10 days after operation for Crohn9s disease, there was a significant fall in fibronectin concentrations of 43% (p less than 0.01, Wilcoxon9s rank-sum test). This fall was maximal on the second postoperative day and was more marked in patients undergoing more major operative procedures. (3) The predictive value of plasma fibronectin for subsequent stricture formation or progression was studied for one year; during which 10 patients developed strictures requiring operative treatment. Higher plasma fibronectin concentrations were related to stricture formation, although there was not a complete, predictive relationship. In this study we found that plasma fibronectin concentrations were low in patients with extensive or severe Crohn9s disease, fall after operation and may be related to the risk of stricture formation. This relationship is unlikely to be of clinical value, although it shows the potential significance of fibronectin in the pathogenesis of strictures.
TÆNIA IN INFANCY.
Authors: G. Minges
Journal: JAMA (1884)

Dubuque, Iowa, August 29, 1884. <h3>Editor of Journal of American Medical Association:</h3> In your paper of the 23rd inst., Dr. J. R. Wilkins reports a case of tænia in a child 2½ years old. In my notes of Prof. Monti's lectures, held at the Vienna Poliklinik in the winter of 1878-79, I find mention of a case, said to have occurred in this country, where the infant was only 4 weeks old. To explain the occurrence of tænia at such an early age, it was supposed that the fœtus had swallowed a cysticercus floating in the liquor amnii. Respectfully,
Polymorphonuclear leukocyte function in psoriasis vulgaris
Authors: C.T. PEASE, M. FENNELL, R.C.D. STAUGHTON, D.A. BREWERTON
Journal: British Journal of Dermatology (1987)

Journal Article Polymorphonuclear leukocyte function in psoriasis vulgaris Get access C.T. PEASE, C.T. PEASE Department of Rheumatology, Westminster Hospital, London SW1P 2AP, U.K. Dr C.T.Pease, Rheumatology Department, Westminster Hospital, 17 Page Street, London SW1P 2AP, U.K. Search for other works by this author on: Oxford Academic Google Scholar M. FENNELL, M. FENNELL Department of Rheumatology, Westminster Hospital, London SW1P 2AP, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.C.D. STAUGHTON, R.C.D. STAUGHTON Department of Dermatology, Westminster Hospital, London SW1P 2AP, U.K. Search for other works by this author on: Oxford Academic Google Scholar D.A. BREWERTON D.A. BREWERTON Department of Rheumatology, Westminster Hospital, London SW1P 2AP, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue 2, 1 August 1987, Pages 161–167, https://doi.org/10.1111/j.1365-2133.1987.tb04112.x Published: 01 August 1987
Notched sign and bamboo-joint-like appearance in duodenal Crohn's disease
Authors: A. Hokama, M. Nakamura, Y. Ihama, H. Chinen, K. Kishimoto, F. Kinjo, J. Fujita
Journal: Endoscopy (2008)

Although Crohn’s disease can affect any part of the gastrointestinal tract, the most common lesions are located in the ileum and the colon; gastroduodenal lesions have therefore attracted less attention. We describe a case of Crohn’s disease with characteristic duodenal manifestations.
Gift authorship: a poisoned chalice?
Authors: J. Smith
Journal: BMJ (1994)

The fruits of authorship are usually considered to be sweet. Authorship of a scientific paper leads to grants, jobs, and reputations. This explains why many people accept the “gift” of authorship on papers to which they have contributed nothing intellectually. And, as with all presents, the givers often derive something too. They may use authorship to repay kindnesses, in exchange for authorship of another paper, or— very commonly—to credit their head of department and in so doing gain a stamp of authority on their work. Last week's revelations questioning the scientific validity of papers in the British Journal of Obstetrics and Gynaecology (see p 0000)1 show how the gift can turn sour. Perhaps this scandal will finally undermine gift authorship. At the very least it should make researchers think hard about the responsibilities that come with putting their names on papers.

The full details of the case, at St George's Hospital, London, have yet to emerge, but we know that an inquiry has found no evidence to support the findings of two papers written by Mr Malcolm Pearce and published in the August issue of the British Journal of Obstetrics and Gynaecology. Unfortunately the editor of the journal, Professor Geoffrey Chamberlain, is also a coauthor of one of the papers. We know nothing about Professor Chamberlain's role in the work, but he was quoted …
HIV-1 Utilizes the CXCR4 Chemokine Receptor to Infect Multipotent Hematopoietic Stem and Progenitor Cells
Authors: Christoph C. Carter, Lucy A. McNamara, Adewunmi Onafuwa-Nuga, Mark Shackleton, James Riddell, Dale Bixby, Michael R. Savona, Sean J. Morrison, Kathleen L. Collins
Journal: Cell Host & Microbe (2011)
A REPORT OF PROGRESS ON THE USE OF EPHEDRINE IN A CASE OF MYASTHENIA GRAVIS
Authors: Harriet Edgeworth
Journal: JAMA (1930)

Prior to an attack of influenzal pneumonia in December, 1918, I was considered a healthy, robust person with a capacity for work and exertion above the average. My previous history included the usual childhood diseases, nose and throat infections for which there had been two tonsillectomies, and two attacks of pneumonia. A relapse following the influenzal pneumonia was characterized by a marked prostration and weakness, and a tachycardia which in the absence of organic disease was attributed to a toxic depression of the vagus. A phlebitis also occurred at this time. After several months in bed, during which these symptoms gradually improved, I resumed work in a research laboratory. The pulse rate was still above normal (from 100 to 120) and there was an increased fatigability. During the next five years, while working full time, there seemed to be an improvement in strength although exertion was followed by excessive fatigue
Prenatal exposure of the northern Québec Inuit infants to environmental contaminants.
Authors: G Muckle, P Ayotte, E Dewailly E, S W Jacobson, J L Jacobson
Journal: Environmental Health Perspectives (2001)

The Inuit population residing in Nunavik (northern Québec, Canada) relies on species from the marine food web for subsistence and is therefore exposed to high doses of environmental contaminants such as polychlorinated biphenyls and methylmercury and to a lesser extent lead. In view of the neurotoxic properties of these substances following developmental exposure, we initiated a study on infant development in this remote coastal population. Here we report the magnitude of prenatal exposure to these contaminants and to selective nutrients in Inuit mothers and their newborns who were recruited on the Hudson Bay coast. We conducted interviews during the women's pregnancies and at 1 and 11 months postpartum and collected biological samples for mercury, lead, polychlorinated biphenyls (PCBs), and chlorinated pesticides analyses as well as selenium and N-3 polyunsaturated fatty acids (n3-PUFA). Cord blood, maternal blood, and maternal hair mercury concentrations averaged 18.5 microg/L, 10.4 microg/L, and 3.7 microg/g, respectively, and are similar to those found in the Faroe Islands but lower than those documented in the Seychelles Islands and New Zealand cohorts. Concentrations of PCB congener 153 averaged 86.9, 105.3, and 131.6 microg/kg (lipids) in cord plasma, maternal plasma, and maternal milk, respectively; prenatal exposure to PCBs in the Nunavik cohort is similar to that reported in the Dutch but much lower than those in other Arctic cohorts. Levels of n3-PUFA in plasma phospholipids and selenium in blood are relatively high. The relatively low correlations observed between organochlorine and methylmercury concentrations may make it easier to identify the specific developmental deficits attributable to each toxicant. Similarly, the weak correlations noted between environmental contaminants and nutrients will facilitate the documentation of possible protective effects afforded by either n3-PUFA or selenium against neurotoxic contaminants.
Peking? What's Rung?
Authors: Samuel Vee
Journal: JAMA (1971)

<h3>To the Editor.—</h3> It is no secret that the meetings of the Canadian and American Medical associations have suffered lately from severe malattendance. Some blame it on unpopular official policies, others on unpalatable scientific programs. Here, in the sticks, we see a much more obvious culprit—the convention site. Plainly, there is little attraction in dilapidated boardwalks or in noisy streets of oft-visited cities. The key to a better attendance is a more appealing locale. And what, pray, can be more enticing than Peking? Let us then, cutting red tape and ignoring red herrings, reroute our national and international meetings to Red China, where behind the Great Wall in the shadows of ancient pagodas, we can blend the latest in medical science with the distillate of "Mao's Thoughts." Endorsing this suggestion, our local poets, abetted by that visiting great Hawaiian bard, G. G. Liddle, composed an appropriate poem which, hopefully, will
Radiotherapy for Acne And Thyroid Carcinoma
Authors: Herbert S. Alden
Journal: JAMA (1967)

<h3>To the Editor:—</h3> I note with some dismay both the title and the content of a paper labeled "Thyroid Carcinoma After Radiation Therapy for Adolescent Acne Vulgaris." The authors make some totally unwarranted and undocumented statements. The authors state: "Because a causal relationship between incidental radiation to the thyroid and carcinogenesis cannot be disproved, radiation therapy for acne and other benign diseases of the head and neck should be abandoned in the adolescent patient." In general, such a conclusion is totally unwarranted by the content of their paper as well as by the broad experience of dermatologists in their treatment of acne.
Hyperpigmentation associated with oral minocycline
Authors: H.A. RIDGWAY, T.S. SONNEX, C.T.C. KENNEDY, P.R. MILLARD, W.J. HENDERSON, S.C. GOLD
Journal: British Journal of Dermatology (1982)

Two patient receiving minocycline developed blue-black pigmentation on the legs. Biopsies from the pigmented areas demonstrated granules containing iron, a pigment with staining properties similar to melanin, and a third pigment which may be a degradation product of minocycline. Electron microscopy showed that some, but not all the granules were membrane-bound and they were situated mainly within macrophages. Analytical electron microscopy showed that the granules contained iron, sulphur, chlorine and, in one case, calcium.
Secular Trends in Long-term Sustained Hypertension, Long-term Treatment, and Cardiovascular Mortality
Authors: Pamela A. Sytkowski, Ralph B. D’Agostino, Albert J. Belanger, William B. Kannel
Journal: Circulation (1996)

Background Cardiovascular morbidity and mortality result from the chronic processes involved in hypertension. However, long-term sustained (LTS) hypertension has received little attention. Methods and Results Trends in the prevalence of LTS hypertension and its treatment were assessed in 1950, 1960, and 1970 among three cohorts of men and women in the Framingham Heart Study (Mantel-Haenszel test). Cardiovascular disease (CVD) incidence and mortality were compared between patients with LTS hypertension with and without long-term treatment by use of the χ 2 test. Cox proportional hazards regression analysis was used to estimate 10-year risk of death as a function of risk factor levels and treatment. Prevalence of LTS hypertension rose from 138 to 208 per 1000 between the 1950 and 1970 male cohorts ( P &lt;.01), while prevalence fell from 253 to 198 per 1000 between the female cohorts ( P &lt;.02). Long-term treatment increased 51% between the male cohorts and 45% between the female cohorts (both P &lt;.001). While CVD incidence was similar (26% versus 25%), all-cause mortality was significantly lower among men with long-term treatment (31% versus 43%; P &lt;.05), and CVD mortality was less than half (13% versus 28%; P &lt;.01). Among treated women, all-cause mortality was 21% (versus 34%; P &lt;.01), and CVD mortality was 9% (versus 19%; P &lt;.01). Ten-year risk of CVD death for patients with LTS hypertension with long-term treatment compared with those without was 0.40 (95% CI, 0.27 to 0.60). Conclusions This investigation of LTS hypertension, its treatment, and its sequelae in a free-living general population confirms the reduction in CVD mortality demonstrated in more short-term clinical trials of hypertension therapy in select patient groups.
Experience based treatment of head lice
Authors: L. Crossan
Journal: BMJ (2002)

EDITOR—Head lice are a familiar problem to most doctors, but especially to general practitioners and those who have children. Ten of the 17 responses to Dodd's editorial were from doctors, and all but four were from the United Kingdom. 1 2 Many respondents enthusiastically described the strategies that had worked for their children, most favouring variations on the theme of wet combing, a strategy deemed ineffective in the editorial.

Robert Bunney, one of four general practitioners responding, reports that his children repeatedly required treatment, and although the infestations usually responded to various pediculicides, the children soon became reinfected. In exasperation he turned to wet combing and kept them clear until the epidemic waned. The combing method, he adds, although initially seeming to have less success than pediculicides, will at least retain or even increase its effectiveness as parents become more skilled in using it and realise that resistance can't occur.

C H Kimberley, another general practitioner, says: “We are regularly told that head lice only transfer on prolonged head to head contact, that head lice …
E coli Otitis Media
Authors: Arnold Chanin
Journal: JAMA (1971)

To the Editor.—  On April 22,1971, a 21-year-old woman was referred to me by a podiatric surgeon because of delayed healing following foot surgery three weeks earlier. She had been treated with ampicillin for one week. A fasting blood glucose level was 82 mg/100 ml. A residual eczematoid reaction was present in the area of the foot surgery. Of note, however, was a perforated left tympanic membrane with drainage. This drainage had been present as long as she could remember, at least for 14 years. She had consulted several otologists and had been treated with various drops, antibiotics, and a polypectomy in 1965, all to no avail. A culture had never been done.  When the drainage was prominent, she returned for a culture. Since she had received ampicillin for the foot problem, I assumed that she had a long-standing Pseudomonas infection. Much to my surprise, the culture report showed heavy
Transvenous atrial septal defect occlusion in piglets with a "buttoned" double-disk device.
Authors: E B Sideris, S E Sideris, J P Fowlkes, R L Ehly, J E Smith, R E Gulde
Journal: Circulation (1990)

The feasibility and safety of transvenous closure of atrial septal defects by a new device was tested in 20 piglets, in which atrial septal defects were created by foramen ovale dilatation with angioplasty balloons. The device was small enough to be introduced in a 7F or 8F sheath, and it measured 20-25 mm. It has no hooks and consists of a foam occluder from the left atrium and a counter-occluder from the right atrium, buttoned independently. The animals were observed by angiography and color flow mapping, and they were electively killed at various intervals up to 2 months after occlusion. The device was not thrombogenic and had endothelialized by 2-3 weeks. All atrial defects were found to be completely occluded. Complications occurred only with the first three prototype devices, including counter-occluder detachment, right atrial perforation, and need for double occlusion and pulmonary artery embolization. No such complications occurred in the last 17 experiments because of modifications of the device and operator experience. These observations showed the feasibility of occlusion of moderate-size atrial septal defects in piglets by a new device introduced through a small sheath. The method appears promising for potential human application.
756-4 Dual Chamber Pacing in Refractory Hypertrophic Obstructive Cardiomyopathy: A Two-Center European Experience in 34 Consecutive Patients
Authors: Nicolas Sadoul, Alistair K.B. Slade, Jean Philippe Simon, Richard C. Saumarez, Bernard Dodinot, Etienne Allot, William J. McKenna
Journal: Journal of the American College of Cardiology (1995)