tbuckley/cabot-search huggingface dataset:
50-Hertz magnetic field and calcium transients in Jurkat cells: results of a research and public information dissemination (RAPID) program study.
Authors: H E Wey, D P Conover, P Mathias, M Toraason, W G Lotz
Journal: Environmental Health Perspectives (2000)

An effect on intracellular calcium continues to be proposed as a biochemical pathway for the mediation of biologic effects of electrical-power-frequency magnetic fields (MF). However, reproducible results among laboratories are difficult to attain and the characteristics of magnetic field effects on intracellular free calcium ([Ca(2+)](i)) are not well understood. We attempted to repeat the studies of Lindström et al. [Intracellular Calcium Oscillations in a T-Cell Line by a Weak 50 Hz Magnetic Field. J Cell Physiol 156:395-398 (1993)] by investigating the effect of a 1.5-G 50-Hz MF on [Ca(2+)](i) in the Jurkat lymphocyte T-cell line. Changes in [Ca(2+)](i) were determined using microscopic imaging of fura-2 loaded Jurkat cells on poly-l-lysine-coated glass coverslips. The MF was generated by a single coil constructed with bifilar wire and located in the same plane as the cells. Cells were randomly exposed for 8 min to MF, sham field (SF), or no field (NF) conditions. The exposure condition remained coded until data analysis was complete. Each exposure period was preceded by an 8-min data collection to establish a baseline for [Ca(2+)](i). After each exposure condition, cells were exposed to anti-CD3 antibody that induced a rapid increase in [Ca(2+)](i) in responsive cells; this provided a positive control. [Ca(2+)](i) was analyzed for individual cells as spatially-averaged background-corrected 340/380 nm ratios, and a [Ca(2+)](i) transient was considered significant for positive deviations from baseline of 3 [multiple] an estimate of noise in the baseline. Typically, 25-50 cells/field were viewed and approximately 50% had no [Ca(2+)](i) transients in the baseline period and also responded to positive control. Only cells responding to positive control and lacking changes in [Ca(2+)](i) during the baseline period were considered qualified for assessment during the exposure period. The incidences of [Ca(2+)](i) transients during the exposure period for two experiments (40 [multiple] objective) were 16.5, 14.6, and 14.2% for MF, SF, and NF, respectively, and were not statistically significantly different. Previous studies by Lindström et al. [Intracellular Calcium Oscillations in a T-Cell Line after Exposure to Extremely-Low-Frequency Magnetic Fields with Variable Frequencies and Flux Densities. Bioelectromagnetics 16:41-47 (1995)] showed a high response rate (92%) for exposure to 1. 5-G 50-Hz MF when individual cells were preselected for investigation. We found no such effect when examining many cells simultaneously in a random and blind fashion. These results do not preclude an effect of MF on [Ca(2+)](i), but suggest that responsive cells, if they exist, were not identified using the approaches that we used in this study.
ANTHRACOSIS AND SILICOSIS IN PULMONARY TUBERCULOSIS
Authors: C. E. Perry
Journal: JAMA (1927)

<h3>To the Editor:</h3> —In the editorial on anthracosis and silicosis in relation to pulmonary tuberculosis (The Journal, November 5), attention is called to the fact that the death rate shown for the group of miners and quarrymen was second to the lowest rate, but that it was believed on good grounds that, had the occupations been separated, that for the miners would have been lower. I believe this to be correct. Again, the United States census is quoted as showing that the group "marble and stone cutters, in whom the dust inhaled also has a high silica content, comprised the occupational group with the highest mortality from tuberculosis." The latter is even more misleading than the first. This group, I believe, should show the rate for marble and limestone workers separately. Marble and limestone have been shown to contain a minimum of silica and are relatively innocuous, and if grouped
Ureteral Reflux as Genetic Trait
Authors: Harry C. Miller
Journal: JAMA (1972)

In a study of pedigrees of ten families, an increased frequency of ureteral reflux was found. Some members with ureteral reflux do not show any other symptoms. The distribution of affected individuals in sibships suggests a dominant gene, but the fact that affected offspring are frequently found in families of two nonaffected parents contradicts this assumption. The involvement of a dominant gene with incomplete expression is tentatively proposed.
Introduction to Environmental Health
Authors: Glyn G. Caldwell
Journal: JAMA (1985)

The preface indicates that this relatively brief book (eight chapters) is intended to serve as a general introductory text for medical, nursing, and public health students. The book provides cogent explanations and definitions of both environmental health and environmental epidemiology and outlines well both the host and environmental components. Each environmental cause of disease (infectious agents, chemicals, and radiation) is specifically discussed. In addition, sections deal with environmental issues, such as air pollution, occupation, and hazardous waste management, that cross all etiological agent categories. There are also sections dealing with selected environmental and occupational health laws. Water pollution is discussed generally in the chapters on infectious agents and chemicals. It is also acknowledged that injury is an important hazard in the general and occupational environment. There are only a few tables and figures, but they enhance the text well, adding to the reader's understanding. Likewise, the ten-page index is reasonably
Protection of ischaemic myocardium with coenzyme Q10
Authors: Y. NAKAMURA, M. TAKAHASHI, J. HAYASHI, H. MORI, S. OGAWA, Y. TANABE, K. HARA
Journal: Cardiovascular Research (1982)

Protection of the ischaemic myocardium with Coenzyme Q10 (COQ10) following constriction of left anterior descending coronary artery was studied in 38 open-chest mongrel dogs. Left anterior descending coronary artery blood flow was independently reduced by tightening a constrictor around the vessel. Aortic pressure and left ventricular pressure were measured, and the Tension Time Index (TTI) was calculated. Myocardial segment shortening in the ischaemic area was measured with an ultrasonic dimension gauge. After obtaining haemodynamic data, the ischaemic myocardium was biopsied and the tissue sample was frozen in liquid nitrogen for adenosine triphosphate (ATP) analysis. Animals premedicated with COQ10 (20 mg . kg-1 iv) had a significantly higher ATP content in ischaemic myocardium (3.25 +/- 0.35 mumol . g-1 wet weight) compared with that in ischaemic myocardium of control animals (2.96 +/- 0.19) (P less than 0.05), when coronary blood flow was reduced by 50 to 74%. There were failure of ATP preservation by COQ10 with a further reduction in coronary blood flow. Changes in the pattern of myocardial segment shortening in the ischemic area induced by a 50 to 74% coronary blood flow reduction were less in COQ10 treated animals than in control animals. Since there were no haemodynamic differences between control and COQ10 treated animals, these effects were considered not to be due to a decrease in myocardial oxygen consumption secondary to haemodynamic changes.
Psychological Well-Being in Rheumatoid Arthritis: Relationship to ‘Disease’ Variables and Affective Disturbance
Authors: Lara Mangelli, Nora Gribbin, Stefan Büchi, Simon Allard, Tom Sensky
Journal: Psychotherapy and Psychosomatics (2002)

Resilience is likely to be important in understanding psychological responses to chronic physical illnesses. This study aimed to examine one measure of resilience--Ryff's operationalized measure of psychological well-being (PWB)--in rheumatoid arthritis. It was hypothesized that PWB would be influenced by age and gender in the same way as in community samples, and that the absence of current mood disorder would be associated with high PWB.Rheumatology clinic outpatients (n = 104) were assessed for pain, disease activity, disability, depression and anxiety. PWB was assessed using Ryff's six-subscale model. The measured variables were used in a logistic regression analysis to model the absence of clinically important mood disorder.The expected variations in PWB according to age and gender were largely absent, with the overall findings suggesting that chronic illness in general, rather than arthritis in particular, affects PWB. Significant bivariate correlations were found between depression and pain, disease activity, disability and all six PWB subscales. However, in the regression analysis, only the PWB environmental mastery subscale and self-rated disability made significant contributions to the absence of mood disturbance, and their inclusion in the regression model correctly classified 81% of the total sample.These results require replication in a longitudinal study, but indicate the potential value of using PWB among people with rheumatoid arthritis to screen for individuals who may be particularly vulnerable to developing depression. It might be appropriate to target such people with focused psychological interventions.
Value of magnetic resonance imaging of the breast as a screening tool remains uncertain
Authors: A J Potterton, A Coulthard
Journal: BMJ (1997)

Doctors should work towards elimination of all firearms and knivesEditor-With the publication of the Cullen report into the shooting of several children at a school in Scotland 1 and the cross party support in parliament to increase the controls on handguns, the moment is ripe for the medical profession to pursue a new health campaign.Over the past three or four decades the profession has had some success in raising public awareness of the risks of cigarette smoking and through that, probably, in saving lives.The reduction of the suicide rate is an objective of the Health of the Nation for England, yet suicide rates are still rising among young men. 2 Homicide is a major political issue.Weapons, especially firearms and knives, contribute to both these forms of premature death.Elimination of all firearms and knives that are surplus to domestic and industrial requirements would not solve either problem entirely, but it would make an important contribution.We believe that the profession, through the BMA and one or two royal colleges (particularly the Royal College of Psychiatrists), could develop policies about weapons control.The prime minister has already indicated that he would introduce controls on knives if a workable definition for the surplus ones was drawn up.
Smoking and human papillomavirus infection. Cervical epithelium vulnerable in smokers.
Authors: K E Rogstad, C Dixon, I H Ahmed-Jushuf
Journal: BMJ (1993)

Epidemiologicalfeatures ofpatients with cervical abnormalities Mean No of cigarettes smoked daily age (years) 0 (n=77) 1-10 (n=29) 11-20 (n=41) >20 (n=20) Wartvirusinfection(n=87) 23 5 44 18 16 8 Cervical intraepithelial neoplasia: Grade I (n=34) 22-6 15 5 8 4 GradeII(n=26) 245 11 4 8 2 Grade III (n=24) 27-3 7 2 9 61 Burger MPM, Hollema H, Gouw ASH, Pieters WJLM, Quint WGV.Cigarette smoking and human papillomavirus in patients with reported cervical cytological abnormality.
DOES THE SYNTAX SCORE HAVE A RELATION WITH MYOCARDIAL ISCHEMIA?
Authors: Hirokazu Tanaka, Taishiro Chikamori, Satoshi Hida, Yuko Igarashi, Yuka Ohtaki, Chie Shiba, Yasuhiro Usui, Tsuguhisa Hatano, Akira Yamashina
Journal: Journal of the American College of Cardiology (2010)
Protein C inhibitor is expressed in tubular cells of human kidney.
Authors: K P Radtke, J A Fernández, J S Greengard, W W Tang, C B Wilson, D J Loskutoff, I Scharrer, J H Griffin
Journal: Journal of Clinical Investigation (1994)

Protein C inhibitor (PCI) is a serpin that inhibits a number of proteases. PCI is found in urine and binds to kidney epithelial cells. To determine if kidney is a source of PCI, cDNA was produced from human kidney total RNA. Sequencing and restriction mapping showed identity between kidney and liver PCI cDNA sequences. Similar cDNAs were obtained from rhesus monkey kidney and liver RNAs. Conditioned medium from the rhesus monkey kidney cell line CCL7.1 was analyzed on immunoblots, showing a 57,000-D protein band that comigrated with human plasma PCI. Immunohistochemical staining and in situ hybridization of human kidney tissue sections showed that kidney PCI antigen and RNA were confined to tubular cells. The findings are consistent with the idea that PCI is synthesized and localized in kidney tissue where it may provide protease inhibitory activity and suggest that complexes of PCI with urokinase found in human urine may be produced locally in the kidney.
Cardiovascular and sympathetic responses to ouabain injected into the hypothalamus in rats
Authors: I. IYODA, H. TAKAHASHI, L.-C. LEE, H. OKAJIMA, A. INOUE, S. SASAKI, K. TAKEDA, M. YOSHIMURA, H. IJICHI
Journal: Cardiovascular Research (1986)

Journal Article Cardiovascular and sympathetic responses to ouabain injected into the hypothalamus in rats Get access ISAO IYODA, ISAO IYODA From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar HAKUO TAKAHASHI, HAKUO TAKAHASHI From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar LI-CHIK LEE, LI-CHIK LEE From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar HIROSHI OKAJIMA, HIROSHI OKAJIMA From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar ATSUSHI INOUE, ATSUSHI INOUE From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar SUSUMU SASAKI, SUSUMU SASAKI From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar KAZUO TAKEDA, KAZUO TAKEDA From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar MANABU YOSHIMURA, MANABU YOSHIMURA From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar HAMAO IJICHI HAMAO IJICHI From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 20, Issue 4, April 1986, Pages 294–298, https://doi.org/10.1093/cvr/20.4.294 Published: 01 April 1986
Insulin-like growth factor system components in hyperparathyroidism and renal osteodystrophy
Authors: Peter M. Jehle, Antje Ostertag, Klaus Schulten, Walter Schulz, Daniela R. Jehle, Sylvia Stracke, Roman Fiedler, Heinz J. Deuber, Frieder Keller, Bernhard O. Boehm, David J. Baylink, Subburaman Mohan
Journal: Kidney International (2000)
Man as the Intermediate Host of the Taenia Solium
Authors: E. J. H. Roth
Journal: BMJ (1926)

SOLIUMt-tY B arid duodenum, is niot an easy matter to decide.A resection of tthe whole nlicer-bearing area, wlhilst a logical pirocedure, is.render-ed difficult in many cases by the fixity of the duodenum.It was only carried out in two casesTABLE L.-Operative Treatmennt in 42 Cases of Coincident Gast)ic (Il1l D)iodenal Ulcer.Operation.No. of Result.Present State. Cae.Posterior gastro-enterostoimy ... 7 7 R.3 perfectly well; 4 still complain of gastric symptoms.Anterior gastro-eniterostomy and 3 3 R.2 very well; 1 still lateral anastoino.-iscomplaining.Gastro-duoodenostolny ... 1 ... 1 1 D.Death from pulmonary embolism on tenth day.Excision of ulcer an(d posterior 2 2 R. 1 very well; 1 late gastro-enterostoin 3, recurrenceof sym- ptolms.Excision and anterior gastro-enter-1* 1 D. Death few hours ostomy after operation.Excisioni and gastro-duodenostomy 1 1 R. Patient very well.Cantery and posterior gastro-enter-15 15 R.All very well.ostolmy Cautery and gastro-duodenostomlly 1 1 R. Very well.Pyloroplasty .1 1 R. Very well.Double gastro-enterostomy and 1 1 R. Very well.lateral anastomosis Gastro-gastrostomy and posterior 2 2 R.Both very well.gastro-enterostomy Gastro-gastrostoiny and gastro- 1 1 R. Very well.duodenostomy Gastro-gastrostomiiy and gast:o- 1 1 R. Very well.duodenostomy and duodeno- jejunostomy Pyloric exclusion and gastro-enter- 1 1
Prognosis and politics
Authors: Fiona Godlee
Journal: BMJ (2008)

Given how common head injuries are, it’s surprising how little we know about their prognosis. But help is at hand. Based on their MRC CRASH trial, Pablo Perel and colleagues have produced new prognostic models for patients with traumatic brain injury (doi: 10.1136/bmj.39461.643438.25). An editorial explains that better understanding of prognosis will not only improve clinical care but will help us design better clinical trials (doi: 10.1136/bmj.39461.616991.80).

Improving prognosis almost always means rapid diagnosis and effective treatment. Two conditions where this is especially important are acute myocardial infarction and severe sepsis. Christian Juhl Terkelsen and Jens Flensted Lassen conclude that we need more …
Changes in the sublingual microcirculation and endothelial adhesion molecules during the course of severe meningococcal disease treated in the paediatric intensive care unit
Authors: Fauzia Paize, Richard Sarginson, Niten Makwana, Paul B. Baines, Alistair P. J. Thomson, Ian Sinha, C. Anthony Hart, Andrew Riordan, Kay C. Hawkins, Enitan D. Carrol, Christopher M. Parry
Journal: Intensive Care Medicine (2012)
OBSERVATIONS ON THE TREATMENT OF ARSPHENAMINE DERMATITIS WITH SODIUM THIOSULPHATE.
Authors: Foong Kong Chen
Journal: British Journal of Dermatology (1926)

Journal Article OBSERVATIONS ON THE TREATMENT OF ARSPHENAMINE DERMATITIS WITH SODIUM THIOSULPHATE. Get access FOONG KONG CHEN, M.A., M.B., CH.B. FOONG KONG CHEN, M.A., M.B., CH.B. Division of Dermatology of the Department of Medicine, Peking Union Medical College, Peking, China Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 38, Issue 1, 1 January 1926, Pages 20–26, https://doi.org/10.1111/j.1365-2133.1926.tb13155.x Published: 01 January 1926
Relations Between Psychiatry and Psychology
Authors: S. Dale Loomis
Journal: JAMA (1966)

<h3>To the Editor:—</h3> I found the article to be seriously lacking in two principle areas. It came as something of a shock to find the relationship between the medical specialist in psychiatry and the clinical psychologist overlooked. This is an area of continuing difficulty. I feel that for Dr. Dickel to disregard the position of the medical specialist in this particular field is to negate the effectiveness that his article might otherwise have had. Although skirting the periphery, the article evaded the area of greatest conflict between the medical specialist and the clinical psychologist—the current trend to an assumption of treatment responsibility by the nonmedical specialist in mental health fields.
THE EFFECT OF THE ROUTE OF IMMUNIZATION ON THE IMMUNITY RESPONSE TO PNEUMOCOCCUS TYPE I
Authors: Ernest G. Stillman
Journal: The Journal of Experimental Medicine (1930)

1. The sera of 80 per cent of the rabbits intravenously inoculated with fixed amounts of heat-killed pneumococci contained agglutinins and all showed protective antibodies. 2. The sera of 60 per cent of the intraperitoneally inoculated rabbits contained agglutinins and all showed protective antibodies. 3. The sera of 33 per cent of the intramuscularly inoculated rabbits contained agglutinins and 86 per cent also showed protective antibodies. 4. None of the sera of the subcutaneously inoculated rabbits contained agglutinins although protective antibodies were present in 71 per cent. 5. Although there is a close relationship between the presence of agglutinins and protective antibodies in a given immune serum, these do not run parallel.
Interleukin-1 receptor-related protein ST2 suppresses the initial stage of bleomycin-induced lung injury
Authors: N. Mato, M. Fujii, Y. Hakamata, E. Kobayashi, A. Sato, M. Hayakawa, H. Ohto-Ozaki, M. Bando, S. Ohno, S. Tominaga, Y. Sugiyama
Journal: European Respiratory Journal (2009)

Acute lung injury has a range of causes, and occasionally leads to lethal respiratory failure. Despite advances in treatment, acute lung injury continues to have a high mortality rate, and thus a new therapeutic approach is needed. ST2 is an interleukin (IL)-1 receptor-related protein, and its expression is induced by various inflammatory responses. Recently, ST2 has been speculated to exert anti-inflammatory effects; therefore, we investigated the role of the ST2 in the murine model of acute lung injury. To elucidate the function of ST2 in vivo , mice that transiently overexpressed ST2 protein were prepared using the hydrodynamic gene transfer method, and lung injury was induced by intratracheal administration of bleomycin. In bleomycin-treated ST2-overexpressing mice, the increase of neutrophils in the bronchoalveolar lavage fluid (BALF) was markedly suppressed. Additionally, the levels of tumour necrosis factor-α and IL-6, as well as the concentration of albumin, in BALF were reduced compared with those of controls. Furthermore, the pulmonary architecture in ST2-overexpressing mice remained almost normal, and the survival rate was significantly improved. From these results, we concluded that ST2 has the potential to suppress the initial stage of acute lung injury, and therefore it may be a useful reagent for the treatment of acute lung injury.
Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction
Authors: Rémy Bosselut, Weiguo Zhang, Jennifer M. Ashe, Jeffrey L. Kopacz, Lawrence E. Samelson, Alfred Singer
Journal: The Journal of Experimental Medicine (1999)

Linker for activation of T cells (LAT) is an adaptor protein whose tyrosine phosphorylation is critical for transduction of the T cell receptor (TCR) signal. LAT phosphorylation is accomplished by the protein tyrosine kinase ZAP-70, but it is not at all clear how LAT (which is not associated with the TCR) encounters ZAP-70 (which is bound to the TCR). Here we show that LAT associates with surface CD4 and CD8 coreceptors and that its association is promoted by the same coreceptor cysteine motif that mediates Lck binding. In fact, LAT competes with Lck for binding to individual coreceptor molecules but differs from Lck in its preferential association with CD8 rather than CD4 in CD4(+)CD8(+) thymocytes. Importantly, as a consequence of LAT association with surface coreceptors, coengagement of the TCR with surface coreceptors induces LAT phosphorylation and the specific recruitment of downstream signaling mediators to coreceptor-associated LAT molecules. These results point to a new function for CD4 and CD8 coreceptors in TCR signal transduction, namely to promote LAT phosphorylation by ZAP-70 by recruiting LAT to major histocompatibility complex-engaged TCR complexes.