tbuckley/cabot-search huggingface dataset:
Angio-Immunoblastic Lymphadenopathy
Authors: FREDERICK A. TOLLE
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 April 1977Angio-Immunoblastic LymphadenopathyFREDERICK A. TOLLE, M.D.FREDERICK A. TOLLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-4-507 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The natural course of angio-immunoblastic lymphadenopathy is not known. To date most patients have been treated with intensive cytotoxic chemotherapy; about one half of patients have died within 2 years of disease onset. Most of these deaths have been attributable to infection, mainly pulmonary (1, 2). Iseman, Schwarz, and Stanford (3) describe a patient with pulmonary infiltrates that pathologically are consistent with angio-immunoblastic lymphadenopathy. The pulmonary infiltrates disappear without therapy, while constitutional symptoms and pancytopenia develop insidiously. With high-dose prednisone therapy (80 mg/day), the symptoms abate and hematologic values improve. Because lymph nodes of patients before and...References1. FRIZZERAMORANRAPPAPORT GEH: Angio-immunoblastic lymphadenopathy: diagnosis and clinical course. Am J Med 59:803-818, 1975 CrossrefMedlineGoogle Scholar2. LUKESTINDEL RB: Immunoblastic lymphadenopathy: a hyperimmune entity resembling Hodgkin's disease. N Engl J Med 292:1-8, 1975 CrossrefMedlineGoogle Scholar3. ISEMANSCHWARZSTANFORD MMR: Interstitial pneumonia in angio-immunoblastic lymphadenopathy with dysproteinemia. A case report with special histopathologic studies. Ann Intern Med 85:752-755, 1976 LinkGoogle Scholar4. RAPPAPORTMORAN HE: Angio-immunoblastic (immunoblastic) lymphadenopathy. N Engl J Med 292:42-43, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Indiana University School of Medicine 1100 W. Michigan St. Indianapolis, IN 46202 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1977Volume 86, Issue 4Page: 507-508KeywordsCytotoxic chemotherapyLymph nodesPulmonary diseases Issue Published: 1 April 1977 PDF DownloadLoading ...
Direct cloning of leukemia-reactive T cells from patients treated with donor lymphocyte infusion shows a relative dominance of hematopoiesis-restricted minor histocompatibility antigen HA-1 and HA-2 specific T cells
Authors: F M Kloosterboer, S A P van Luxemburg-Heijs, RA van Soest, A M Barbui, HM van Egmond, M P W Strijbosch, M G D Kester, W A F Marijt, E Goulmy, R Willemze, J H F Falkenburg
Journal: Leukemia (2004)
Social cognition and psychopathology: a critical overview
Authors: Shaun Gallagher, Somogy Varga
Journal: World Psychiatry (2015)

The philosophical and interdisciplinary debate about the nature of social cognition, and the processes involved, has important implications for psychiatry. On one account, mindreading depends on making theoretical inferences about another person's mental states based on knowledge of folk psychology, the so-called "theory theory" (TT). On a different account, "simulation theory" (ST), mindreading depends on simulating the other's mental states within one's own mental or motor system. A third approach, "interaction theory" (IT), looks to embodied processes (involving movement, gesture, facial expression, vocal intonation, etc.) and the dynamics of intersubjective interactions (joint attention, joint action, and processes not confined to an individual system) in highly contextualized situations to explain social cognition, and disruptions of these processes in some psychopathological conditions. In this paper, we present a brief summary of these three theoretical frameworks (TT, ST, IT). We then focus on impaired social abilities in autism and schizophrenia from the perspective of the three approaches. We discuss the limitations of such approaches in the scientific studies of these and other pathologies, and we close with a short reflection on the future of the field. In this regard we argue that, to the extent that TT, ST and IT offer explanations that capture different (limited) aspects of social cognition, a pluralist approach might be best.
A skin rash to remember
Authors: P. J. Moran, P. Geoghegan, D. J. Sexton, A. O'Regan
Journal: BMJ (2012)

A 30 year old man presented to the emergency department with a four to five day history of a painful disfiguring rash (fig 1⇓). It started around his mouth but later spread to the rest of his face, as well as his neck and shoulders. He had a history of mild atopic dermatitis, but he had been otherwise well apart from a “cold sore” before the rash appeared. He was not taking any regular drugs, had no allergies, and had not treated the rash with any topical drugs. He was systemically well and the only abnormalities seen on routine blood tests were mild lymphopenia (0.8×109/L, reference range 1-4) with raised C reactive protein 64 mg/L (<0.6;1 mg/L=9.5 nmol/L). HIV testing was negative.





### 1 What is the diagnosis?

#### Short answer

Eczema herpeticum, with secondary staphylococcal superinfection. This is a dermatological emergency.

#### Long answer

Possible diagnoses include eczema herpeticum with secondary staphylococcal superinfection, viral xanthems (such as pox viruses), bacterial infection, drug eruption, contact dermatitis, erythema multiforme, or exacerbation of a primary skin disorder. The appearance of the rash is not typical of an isolated flare of atopic dermatitis. The absence of recent use of drugs excludes a drug eruption and the distribution is not consistent with contact dermatitis. Nor are the lesions typical of erythema multiforme. Given the recent history of a cold sore, the appearance of the rash with an initial monomorphic vesicular eruption, and subsequent punched out erosions and impetiginous change, the most likely diagnosis is eczema herpeticum, with secondary staphylococcal superinfection.

Eczema herpeticum is caused by herpes simplex virus …
Oesophageal varices treated by sclerotherapy: a histopathological study.
Authors: D M Evans, D B Jones, B K Cleary, P M Smith
Journal: Gut (1982)

Of 31 cases of haemorrhage from oesophageal varices treated by sclerotherapy eight came to necropsy. The oesophagus and proximal stomach were studied by means of a serial block technique and the histopathological findings in each case were recorded on two full-scale maps: one representing superficial tissues including the submucosa and the other the deeper tissues. The patterns of thrombosis, ulceration, necrosis, and fibrosis were studied in relation to the time interval since injection. Thrombosis and tissue necrosis were present within 24 hours of sclerotherapy, ulceration after seven days, and fibrosis after a month. Fibrosis was sometimes associated with stricture formation, which readily responded to dilatation. Patients with fibrosis had a reduced incidence of rebleeding.
Effect of Prolonged Hypoxia Upon Granularity of Renal Juxtaglomerular Cells
Authors: WILLIAM J. OLIVER, GERALD L. BRODY
Journal: Circulation Research (1965)

The various experimental models used in previous studies of the juxtaglomerular apparatus do not permit the effect of changes in oxygen tension of the renal parenchyma to be separated from that of changes in distension of the renal arterial bed. To study the isolated effect of prolonged hypoxia, three groups of rats, matched for weight, were kept in low oxygen, room air, and high oxygen environment for two weeks. The animals were pair-fed with the hypoxic rats serving as the determinant group. Supplemental injections of sodium chloride were given daily to avoid the effect of sodium deprivation on the juxtaglomerular cells. It was found that the hematocrits and also the granularity of the juxtaglomerular cells were significantly increased in the hypoxic rats as compared to the other two groups. Blood pressures, serum sodium levels, and urinary excretion of sodium were comparable among the three groups. These findings demonstrate that increased granularity of the renal juxtaglomerular cells can be induced by prolonged hypoxia.
Regulation of collecting tubule adenosine triphosphatases by aldosterone and potassium.
Authors: S Eiam-Ong, N A Kurtzman, S Sabatini
Journal: Journal of Clinical Investigation (1993)

To examine the precise role of potassium and aldosterone on acid-base composition and on collecting tubule ATPases, glucocorticoid-replete adrenalectomized rats were replaced with zero, physiological, or pharmacological doses of aldosterone and were fed varying potassium diets to produce hypokalemia, normokalemia, or hyperkalemia. Radiochemical measurement of ATPase activities showed that collecting tubule H/K-ATPase changed inversely with potassium and not with aldosterone whereas H-ATPase changed directly with aldosterone but not with potassium. When both enzymes changed in the same direction, alterations in acid-base composition were profound; however, when these two acidifying enzymes changed in opposite directions or when only one enzyme changed, the effect on acid-base balance was modest. Serum bicarbonate was approximately 45 meq/liter when aldosterone was high and potassium was low; it was only 29 meq/liter when aldosterone was high but potassium was normal or when aldosterone was normal and potassium was low. Our observations may help explain the metabolic alkalosis of primary aldosteronism in which aldosterone excess and hypokalemia are combined and the metabolic acidosis of aldosterone deficiency in which hypoaldosteronism and hyperkalemia are paired. The present study also demonstrated that aldosterone plays the major role in controlling Na/K-ATPase activity in cortical collecting tubule. Hypokalemia stimulates Na/K-ATPase activity in the medullary collecting tubule; this stimulatory effect of hypokalemia supports the hypothesis that the enzyme is present on the apical membrane at this site.
In vitro expansion of CD34+CD38− cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia
Authors: K Sakashita, I Kato, T Daifu, S Saida, H Hiramatsu, Y Nishinaka, Y Ebihara, F Ma, K Matsuda, S Saito, K Hirabayashi, T Kurata, L T N Uyen, Y Nakazawa, K Tsuji, T Heike, T Nakahata, K Koike
Journal: Leukemia (2014)
An open study of pentoxyfylline and thalidomide as adjuvant therapy in the treatment of rheumatoid arthritis.
Authors: T W Huizinga, B A Dijkmans, E A van der Velde, T C van de Pouw Kraan, C L Verweij, F C Breedveld
Journal: Annals of the Rheumatic Diseases (1996)

OBJECTIVE: Dysregulation of tumour necrosis factor alpha (TNF alpha) production is thought to be important in rheumatoid arthritis. Since pentoxifylline and thalidomide inhibit endotoxin induced TNF production in vitro, these drugs were tested in an open study in rheumatoid arthritis patients to assess toxicity, the effect on TNF production, and the antiarthritic effects. METHODS: 12 patients with active rheumatoid arthritis were treated with 1200 mg pentoxifylline and 100 mg thalidomide a day during 12 weeks. In addition, TNF production was assessed by ex vivo whole blood cultures stimulated with endotoxin. RESULTS: Adverse events such as xerostomia, drowsiness, and constipation occurred in almost all patients, which led to discontinuation in three. The drugs halved the TNF production capacity during treatment (ANOVA, P &lt; 0.03) whereas production capacity of interleukin (IL) 6, IL-10, and IL-12 was not affected. Of the nine patients who completed the study, five fulfilled the ACR-20% response criteria after 12 weeks of treatment. CONCLUSIONS: Although pentoxifylline/thalidomide reduced the production capacity of TNF, the benefit/side effects ratio was poor due to multiple adverse effects, while clinical observation suggests limited efficacy.
Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma
Authors: Elizabeth Fox, Bassem I. Razzouk, Brigitte C. Widemann, Shaun Xiao, Michelle O'Brien, Wendy Goodspeed, Gregory H. Reaman, Susan M. Blaney, Anthony J. Murgo, Frank M. Balis, Peter C. Adamson
Journal: Blood (2007)
TCT-847 Strut Level Optical Coherence Tomography Evaluation of Coronary Stent Strut Coverage Temporal Trends: A Systematic Review
Authors: Kwan S. Lee, Justin Z. Lee, Irbaz B. Riaz, Muhammad Husnain, Haris Riaz, Kapil Lotun, Karl B. Kern
Journal: Journal of the American College of Cardiology (2013)
ILLINOIS STATE BOARD OF HEALTH.
Authors: B. M. Griffith
Journal: JAMA (1892)

ABSTRACT FROM THE MINUTES OF THE MEETING OF JULY 27,1892. 1.—Colleges requiring four (4) or more years of study and four (4) or more terms of lectures as conditions of graduation: Chicago Medical College, Medical School, Northwestern University, Chicago, Ill. Harvard University Medical School, Boston, Mass. Boston University School of Medicine, Boston, Mass. Department of Medicine and Surgery, University of Michigan, Ann Arbor, Mich. Homeopathic Medical College, University of Michigan, Ann Arbor, Mich. Leonard Medical School, Raleigh, N. C. McGill University, Faculty of Medicine, Montreal, Que.1 University of Toronto, Faculty of Medicine, Toronto, Ont. Ecole de Medicine et de Chirurgie, Montreal, Que. Trinity Medical College, Toronto, Ont. Laval University, Medical Departments, Quebec and Montreal, Que. Royal College of Physicians and Surgeons, Kingston, Ont. Halifax Medical College, Halifax, N. S. Dalhousie University, Faculty of Medicine, Halifax, N. S. University of Bishop's College, Faculty of Medicine, Montreal, Que. Medical Department of Western
Large Fibrogenic Tumors and Hypoglycemia
Authors: J. C. Thomas Rogers
Journal: JAMA (1961)

Spells of unconsciousness resembling strokes and accompanied by symptoms and findings of hypoglycemia have occasionally been reported in connection with large tumors in the pelvis or abdomen. In the present case a 64-year-old woman had repeated attacks of unconsciousness with temporary right-sided paralysis. The blood sugar, determined on 5 different occasions, ranged from 35 to 58 mg. per 100 cc. A large, fixed mass noted in the pelvis was found at laparotomy to be 20 cm. in diameter and to weigh 1.7 kg. It appeared to be a fibrous mesothelioma of low-grade malignancy and to contain neither any insulin nor any recognizable pancreatic tissue. In the 21/2 years after its removal, the patient has been free from symptoms of hypoglycemia.
Physicians and Journalists-Reply
Authors: Donald F. Phillips
Journal: JAMA (1989)

In Reply.—  Ms Robinson-Haynes offers sound practical advice to physicians on how to approach an interview with journalists, particularly when the researcher-clinician is uncertain about the journalist's competence.  No one would argue with her point that journalists, physicians, and the public would benefit if the journalism and medical professions knew more about each other and established a common ground of understanding. Indeed, both have taken giant steps in seeking this common ground, as witnessed by the growth of science writer seminars sponsored by various scientific and medical organizations.  In fact, all of the participants attending the Case Western Reserve ethics conference agreed, as was stated in my summary of the meeting, that a better understanding and awareness of each other's values are necessary. As also was stated, reaching this common ground is not easy, and the means for doing so deserves more attention and thought.  In general, the participants agreed
Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels
Authors: Maja Klug, Sven Heinz, Claudia Gebhard, Lucia Schwarzfischer, Stefan W Krause, Reinhard Andreesen, Michael Rehli
Journal: Genome biology (2010)

In mammals, the dynamics of DNA methylation, in particular the regulated, active removal of cytosine methylation, has remained a mystery, partly due to the lack of appropriate model systems to study DNA demethylation. Previous work has largely focused on proliferating cell types that are mitotically arrested using pharmacological inhibitors to distinguish between active and passive mechanisms of DNA demethylation.We explored this epigenetic phenomenon in a natural setting of post-mitotic cells: the differentiation of human peripheral blood monocytes into macrophages or dendritic cells, which proceeds without cell division. Using a global, comparative CpG methylation profiling approach, we identified many novel examples of active DNA demethylation and characterized accompanying transcriptional and epigenetic events at these sites during monocytic differentiation. We show that active DNA demethylation is not restricted to proximal promoters and that the time-course of demethylation varies for individual CpGs. Irrespective of their location, the removal of methylated cytosines always coincided with the appearance of activating histone marks.Demethylation events are highly reproducible in monocyte-derived dendritic cells from different individuals. Our data suggest that active DNA demethylation is a precisely targeted event that parallels or follows the modification of histones, but is not necessarily coupled to alterations in transcriptional activity.
ELECTROPHORETIC STUDIES OF THE PLASMA AND SERUM PROTEINS IN SICKLE CELL ANEMIA 1
Authors: Richard L. Fenichel, Janet Watson, Frederick Eirich
Journal: Journal of Clinical Investigation (1950)

1 20 6.3 50.4 3.58 6.30 0.45 9.4 0.65 11.5 0.82 22.4 1.59 1.0 2 20 6.2 47.4 3.24 7.20 0.49 9.9 0.67 12.9 0.88 22.6 1.53 0.9 3 18 7.8 47.0 3.22 6.00 0.41 7.0 0.48 11.5 0.79 29.0 2.00 0.9 4 19 6.7 39.4 3.15 5.40 0.43 6.3 0.50 12.6 1.00 36.3 2.96 0.7
Screening for Hypertension: Some Epidemiological Observations
Authors: W. E. Miall, S. Chinn
Journal: BMJ (1974)

Data obtained in long-term epidemiological studies of arterial blood pressure in the general population in South Wales were analysed to provide background information for the rational planning of screening programmes for hypertension. The incidence rates for cardiovascular complications emphasize the much greater prognostic value of blood pressure measurements in men than in women. Proportionately fewer men are treated for hypertension at all ages and blood pressure levels; in the survey areas treatment for hypertension is less than satisfactory in both sexes but particularly inadequate among men. The data suggest that once a screening programme has been carried out rescreening can be made more efficient by allowing the intervals before re-examination to be determined by the initial findings rather than by age.
Inflammation and caspase activation in long-term renal ischemia/reperfusion injury and immunosuppression in rats
Authors: B.I.N. Yang, Sunjay Jain, Izabella Z.A. Pawluczyk, Shehla Imtiaz, Lee Bowley, Shairbanu Y. Ashra, Michael L. Nicholson
Journal: Kidney International (2005)
Functional exploration of CCNE1splicing forms as a possible link to bladder cancer susceptibility
Authors: Indu Kohaar, Alexandra Scott-Johnson, Yi-Ping Fu, Patricia Porter-Gill, Ludmila Prokunina-Olsson
Journal: Genome biology (2011)

Deep exome resequencing is a powerful approach for delineating patterns of protein-coding variation among genes, pathways, individuals and populations.We analyzed exome data from 2,440 individuals of European and African ancestry as part of the National Heart, Lung, and Blood Institute's Exome Project, the aim of which is to discover novel genes and mechanisms that contribute to heart, lung and blood disorders.Each exome was sequenced to a mean coverage of 116×, allowing detailed inferences about the population genomic patterns of both common variation and rare coding variation.We identifi ed more than 500,000 single nucleotide variations, the majority of which were novel and rare (76% of variants had a minor allele frequency of less than 0.1%), refl ecting the recent dramatic increase in the size of the human population.The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and purifying selection in shaping patterns of proteincoding variation and the diff erential signatures of population structure from rare and common variation.This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health.
Effects of ischaemia and reperfusion on calcium exchange and mechanical function in isolated rabbit myocardium
Authors: P. D V BOURDILLON, P. A POOLE-WILSON
Journal: Cardiovascular Research (1981)

We have studied calcium exchanges and mechanical function in heart muscle during and after a period of ischaemia. The experimental preparation was the isolated but arterially perfused interventricular septum of the rabbit. Uptake of calcium was measured with 47Ca2+ and efflux with 45Ca2+. 51Cr-EDTA was used as a marker of the extracellular space. Ischaemia caused a rapid decline of developed tension followed by a rise in resting tension. Tissue counts of 47Ca2+ decreased due to a reduction in the extracellular space. On reperfusion after ischaemia developed tension partially recovered and resting tension increased further before returning towards control values. A large and prolonged uptake of 47Ca2+ occurred immediately on reperfusion while 45Ca2+ efflux rose transiently. The uptake of calcium was related to the severity and duration of ischaemia and to the degree of mechanical recovery. Calcium accumulation on reperfusion is due to an increased influx which is not related to gross disruption of the cell membrane but more probably to a specific abnormality of ionic channels.
HYPERTHYROXINEMIA IN ACUTE PSYCHIATRIC PATIENTS
Authors: Allan Font, Daniel I. Spratt, I. Ross McDougall, Myrna Miller, William T. McLaughlin, Monika F. Bayer
Journal: Clinical Nuclear Medicine (1981)

Font, Allan; Spratt, Daniel I.; McDougall, I. Ross; Miller, Myrna; McLaughlin, William T.; Bayer, Monika F. Author Information
Microsatellite Analysis of Drosophila melanogaster Populations Along a Microclimatic Contrast at Lower Nahel Oren Canyon, Mount Carmel, Israel
Authors: Christian Schlötterer, Martin Agis
Journal: Molecular Biology and Evolution (2002)

Drosophila melanogaster populations collected at the south-facing slope (SFS) and north-facing slope (NFS) of lower Nahel Oren canyon, Mount Carmel, Israel display significant differences in survival and longevity at temperature, drought, and starvation stresses. Furthermore, significant assortative mating was previously observed between populations of the two slopes. We used a set of 48 microsatellite markers to analyze patterns of genetic differentiation between D. melanogaster populations from both slopes and D. simulans. Consistent with previous reports, we found D. simulans to be well differentiated from D. melanogaster. Genetic differentiation between SFS and NFS D. melanogaster populations was low (FST = 0.0012). Also a tree of individuals based on the proportion of shared alleles and a model-based clustering method provided no evidence for population substructuring.
A Reconsideration of Psychological Specificity in Psychosomatic Disorders
Authors: John C. Nemiah
Journal: Psychotherapy and Psychosomatics (1982)

In this paper, the author identifies the evolution of the specificity hypothesis in the psychogenesis of psychosomatic illness across the last half century. Specifically identified is the distinction made between the mechanism of conversion and that of vegetative neurosis. Considerable attention is addressed to the personality features thought to be common to all psychosomatic patients and the refinement of this theory over the past 40 years, including the present interest in alexithymia. These concepts are explored in the consideration of a man who sustained two different specific conflictual environmental situations. The author emphasizes that our present formulations lead us to focus on the person with the illness and the processes that lead to that illness in the patient.