tbuckley/cabot-search huggingface dataset:
Official Call to the Officers and Members of the American Medical Association to Attend the Annual Convention in St Louis June 18 to 22, 1978
Authors: John H. Budd
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic and Ductus Venosus Blood Flows During Fetal Life
Authors: Abraham M. Rudolph
Journal: Hepatology (1983)

The course of the venous circulation in the fetal liver has been studied in fetal lambs by means of the radionuclide–labeled microsphere technique. About 50% of umbilical venous blood passes through the ductus venosus, while the remainder is distributed to both lobes of the liver. Portal venous blood is largely distributed to the right lobe of the liver, with a small proportion passing through the ductus venosus and none to the left lobe. Because of these flow patterns, oxygen saturation is lower in the right than in the left hepatic vein. Left hepatic venous blood joins the ductus venosus stream and these preferentially pass through the foramen ovale, whereas right hepatic venous blood joins the distal inferior vena caval stream and preferentially passes through the tricuspid valve. These patterns favor distribution of well–oxygenated blood to the fetal heart and brain. Hypoxia and reduced umbilical venous return are associated with reduced flow through the hepatic microcirculation with proportionately greater ductus venosus flow. In the fetus, the liver has a major role in influencing venous return to the heart and in regulating distribution of oxygen and energy substrate supply to different fetal organs.
Expression of the Retinoblastoma Susceptibility Gene in Childhood Rhabdomyosarcomas
Authors: Annarosaria De Chiara, Anne T'Ang, Timothy J. Triche
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Expression of the Retinoblastoma Susceptibility Gene in Childhood Rhabdomyosarcomas Get access Annarosaria De Chiara, Annarosaria De Chiara Search for other works by this author on: Oxford Academic PubMed Google Scholar Anne T'Ang, Anne T'Ang Search for other works by this author on: Oxford Academic PubMed Google Scholar Timothy J. Triche Timothy J. Triche Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 2, 20 January 1993, Pages 152–157, https://doi.org/10.1093/jnci/85.2.152 Published: 20 January 1993
A Surgeon With AIDS
Authors: Ralph H. Harder
Journal: JAMA (1990)

<h3>To the Editor.—</h3> With a disease as life-threatening, contagious, and untreatable as is the acquired immunodeficiency syndrome (AIDS), it is essential that our research be as objective and thorough as possible to avoid false dogma and conclusions. The Original Contribution "A Surgeon With AIDS" by Mishu et al<sup>1</sup>does not satisfy these concerns. In the "Background" to the study, the authors admit that the study was biased to reassure those concerned in Nashville that the risk of AIDS transmission was minimal. The patient list was compared with the State AIDS Registry, which contained AIDS cases only, not human immunodeficiency virus (HIV) positivity, which would be more significant. Of the 2160 surgical patients, only 616 (29%) had HIV titers measured. There is no basis to conclude that "these results support the concept that the risks to patients operated on by HIV-infected surgeons are most
A4.8 GDF15, A Marker of Lung Involvement in Systemic Sclerosis, is Involved in Altered Cytokine Secretion by Fibroblasts, but does not Impair Fibrosis Development
Authors: Stijn Lambrecht, Vanessa Smith, Filip De Keyser, Dirk Elewaut
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objective</h3> Systemic sclerosis is a progressive connective tissue involving autoimmune processes. It is generally known that members of the TGF-β superfamily are involved in the regulation of connective tissue metabolism in systemic sclerosis (SSc), but also in regulating the immune system. Growth differentiation factor 15 is a distant member of this TGF-β family. We aim to evaluate the role of GDF15 in SSc-pathogenesis. <h3>Methods</h3> A longitudinal prospective cohort of SSc patients was screened for GDF15 serum levels by ELISA and associations with disease activity and tissue damage were analysed. Moreover, in vitro stimulation experiments were performed in lung fibroblasts. The role of GDF15 in fibrosis development in vivo was evaluated by performing the bleomycin lung fibrosis model in GDF15 deficient mice. <h3>Results</h3> Serum samples from a cohort of 122 patients were screened for GDF15 levels. An increase in GDF15 levels was observed in patients classified as limited SSc, limited cutaneous SSc and diffuse SSc. Moreover, GDF15 serum levels highly correlated with disease activity and clinical symptoms of lung fibrosis. This was also mimicked in the bleomycin mouse model of SSc. Here, bleomycin exposed animals displayed elevated expression levels of GDF15 in lung tissue. Isolated lung fibroblast of GDF15 deficient mice showed reduced induction of IL6 and CCL2 upon bleomycin stimulation compared to wild-type littermates. Both, IL6 and CCL2, are involved in recruitment and activation of the immune system. Surprisingly, no differences in end-stage fibrosis development were observed between wild-type and GDF15 deficient animals after bleomycin injection. <h3>Conclusions</h3> An intriguing profile of GDF15 serum levels was found in SSc patients. GDF15 expression is induced during fibrosis development. We hypothesise that the altered GDF15 expression by lung fibroblast may contribute to distorted interaction between the immune system and the stromal connective tissue. From our data it is clear that this protein may participate in fibrosis initiation, but is not indispensable in the course of fibrosis development in vivo.
A Simple and Safe Method of Transcutaneous Gastrostomy Replacement Using the Seldinger Technique
Authors: M. Frenz, G. Siuda, A. McIntyre, S. Travis
Journal: Endoscopy (2004)

We report on a simple and safe method of transcutaneous gastrostomy (percutaneous endoscopic gastrostomy; PEG) replacement using the Seldinger technique in combination with vascular dilators. The procedure is illustrated in Figure [1] and 2.
Report of the Second Institute on Clinical Teaching
Authors: A. N. Taylor
Journal: JAMA (1961)

This report, the seventh in a series of teaching institutes sponsored by the Association of American Medical Colleges, gives particular attention to 3 topics: "Medical School Curricula, an Operation on Clinical Teaching"; "The Roles of the University and the Examining Boards in the Education of Medical Students, Interns and Residents"; and "Science and Art in Teaching Responsibility for Patients." The institute, conducted as a "national medical faculty meeting" of 160 participants, was based on information gained through several preinstitute questionnaires. Much of the data is presented in tabular form in about 60 tables throughout the text. Since the report is a compilation of several individual presentations, only general impressions are mentioned. The paradoxical situation of stressing the expanding responsibilities of basic science teaching and the encroachment of clinical "integration" into an already rigid time schedule was recognized, but no enthusiastic solution followed. It was noted that the young physician received
Patient-Centered Community Health Worker Intervention to Improve Posthospital Outcomes
Authors: Shreya Kangovi, Nandita Mitra, David Grande, Mary L. White, Sharon McCollum, Jeffrey Sellman, Richard P. Shannon, Judith A. Long
Journal: JAMA Internal Medicine (2014)

IMPORTANCE Socioeconomic and behavioral factors can negatively influence posthospital outcomes among patients of low socioeconomic status (SES). Traditional hospital personnel often lack the time, skills, and community linkages required to address these factors. OBJECTIVE To determine whether a tailored community health worker (CHW) intervention would improve posthospital outcomes among low-SES patients. DESIGN, SETTING, AND PARTICIPANTS A 2-armed, single-blind, randomized clinical trial was conducted between April 10, 2011, and October 30, 2012, at 2 urban, academically affiliated hospitals. Of 683 eligible general medical inpatients (ie, low-income, uninsured, or Medicaid) that we screened, 237 individuals (34.7%) declined to participate. The remaining 446 patients (65.3%) were enrolled and randomly assigned to study arms. Nearly equal percentages of control and intervention group patients completed the follow-up interview (86.6% vs 86.9%). INTERVENTIONS During hospital admission, CHWs worked with patients to create individualized action plans for achieving patients' stated goals for recovery. The CHWs provided support tailored to patient goals for a minimum of 2 weeks. MAIN OUTCOMES AND MEASURES The prespecified primary outcome was completion of primary care follow-up within 14 days of discharge. Prespecified secondary outcomes were quality of discharge communication, self-rated health, satisfaction, patient activation, medication adherence, and 30-day readmission rates. RESULTS Using intention-to-treat analysis, we found that intervention patients were more likely to obtain timely posthospital primary care (60.0% vs 47.9%; P = .02; adjusted odds ratio [OR], 1.52; 95% CI, 1.03-2.23), to report high-quality discharge communication (91.3% vs 78.7%; P = .002; adjusted OR, 2.94; 95% CI, 1.5-5.8), and to show greater improvements in mental health (6.7 vs 4.5; P = .02) and patient activation (3.4 vs 1.6; P = .05). There were no significant differences between groups in physical health, satisfaction with medical care, or medication adherence. Similar proportions of patients in both arms experienced at least one 30-day readmission; however, intervention patients were less likely to have multiple 30-day readmissions (2.3% vs 5.5%; P = .08; adjusted OR, 0.40; 95% CI, 0.14-1.06). Among the subgroup of 63 readmitted patients, recurrent readmission was reduced from 40.0% vs 15.2% (P = .03; adjusted OR, 0.27; 95% CI, 0.08-0.89). CONCLUSIONS AND RELEVANCE Patient-centered CHW intervention improves access to primary care and quality of discharge while controlling recurrent readmissions in a high-risk population. Health systems may leverage the CHW workforce to improve posthospital outcomes by addressing behavioral and socioeconomic drivers of disease. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT01346462.
Does Particulate Matter Modify the Association between Temperature and Cardiorespiratory Diseases?
Authors: Cizao Ren, Gail M. Williams, Shilu Tong
Journal: Environmental Health Perspectives (2006)

A number of studies have shown that both temperature and air pollution are associated with health outcomes. In assessing air pollution effects, temperature is usually considered a confounder. However, only a few recent studies considered air pollution as confounders while assessing temperature effects. Few studies are available on whether or not air pollution modifies the temperature-disease relationship.
Health Reform and the Health of the Public
Authors: Edward L. Baker, Robert J. Melton, Paul V. Stange, Mimi L. Fields, Jeffrey P. Koplan, Fernando A. Guerra, David Satcher
Journal: JAMA (1994)

REGARDLESS of the direction or timing of the reform of the health care financing system, the nation's health status may not substantially improve without simultaneous reform of the public health system. Reducing administrative complexity and redundancy and, most important, assuring that all US citizens have access to quality medical care will do little to influence the true determinants of ill health: unsafe environments, unhealthy personal behaviors, and biologic, genetic, and socioeconomic factors.<sup>1-3</sup>These determinants account for more than 1 million deaths per year and untold levels of preventable morbidity and expensive (avoidable) health care in the United States.<sup>4</sup>Thus, the concept of health system reform should not be restricted primarily to medical care; it should also encompass strengthening the practice of public health and stimulating new systems of integration among all organizations within a community whose missions have an impact on the health of the public, many of
Does the GMC support apartheid?
Authors: S. Dowling
Journal: BMJ (1984)

visiting might underestimate the size of the prob- lem by a similar amount.The data from Hannay and Fraser and Clayton were not "conveniently overlooked" because they were not "truly com- parable."In neither of these studies was the accuracy of apparently updated addresses on general practitioner lists compared before and after home visiting.The former was solely a home visiting programme, whereas the latter did not provide data on postal returns.Professor Fraser has also confused target population with denominator population in evaluating screening.The former is necessary for assessing population coverage, and the observation that as in the present study 25% of the population could not be contacted is of relevance.Conversely the denominator for determining response or accept- ability of screening, or both, should, as Professor Fraser agrees, exclude these missing individuals.The model Professor Fraser describes for screening would not succeed in the area referred to in this study.His estimates of 95% probability of being contactable and 4% per cent for incorrect patient record addresses are large overestimates given the results of this and the other studies.
A NEUTROPHIL-DEPENDENT PATHWAY FOR THE GENERATION OF A NEUTRAL PEPTIDE MEDIATOR
Authors: Bruce U. Wintroub, Edward J. Goetzl, K. Frank Austen
Journal: The Journal of Experimental Medicine (1974)

A biologically active neutral peptide mediator is cleaved from a plasma protein substrate by an α-1-antitrypsin-inhibitable serine protease apparently residing on the membrane of the human neutrophil. The peptide mediator has an approximate mol wt of 1,000, and is distinguished from the kinin peptides by a neutral isoelectric point, susceptibility to inactivation by trypsin as well as chymotrypsin and activity on the isolated, atropinized, and antihistamine-treated guinea pig ileum with relatively little action on the estrous rat uterus. The neutrophil protease is fully inhibitable by DFP, trypsin inhibitors from lima or soy bean, and α-1-antitrypsin and is associated with the high mol wt fragments of the neutrophil and not the nuclear, lysosomal, or cytoplasmic subcellular fraction. The substrate has an approximate mol wt of 90,000 and is chromatographically separable from kininogen. The exquisite sensitivity of the neutrophil protease to α-1-antitrypsin was established both by inhibition with highly purified α-1-antitrypsin and by the inability of the protease to generate detectable neutral peptide in a homozygous (ZZ) α-1-antitrypsin-deficient patient without heat inactivation of the residual inhibitor. On the other hand, plasma from a (null) α-1-antitrypsin-deficient patient supported neutral peptide generation and revealed an additional factor which inactivated neutral peptide.
Depressed patients need more than drugs and psychiatrists
Authors: S. J Williams
Journal: BMJ (2003)

EDITOR—Rost et al conducted a randomised controlled trial of ongoing treatment of depression in primary care, and Stroebele in response argued that it would make more sense for a patient to see a psychiatrist once and receive drug treatment if necessary for three or six months. 1 2

I do not believe a psychiatrist can make an accurate …
Spermatogenesis in a Man with Complete Deletion of<i>USP9Y</i>
Authors: Alice Luddi, Maria Margollicci, Laura Gambera, Francesca Serafini, Maddalena Cioni, Vincenzo De Leo, Paolo Balestri, Paola Piomboni
Journal: New England Journal of Medicine (2009)

Deletions in the azoospermia factor region AZFa on the human Y chromosome and, more specifically, in the region that encompasses the ubiquitin-specific peptidase 9, Y-linked gene USP9Y have been implicated in infertility associated with oligospermia and azoospermia. We have characterized in detail a deletion in AZFa that results in an absence of USP9Y in a normospermic man and his brother and father. The association of this large deletion with normal fertility shows that USP9Y, hitherto considered a candidate gene for infertility and azoospermia, does not have a key role in male reproduction. These results suggest that it may not be necessary to consider USP9Y when screening the Y chromosome of infertile or subfertile men for microdeletions.
A FATAL CASE OF ERYTHEMA MULTIFORME FOLLOWING DEEP X-RAY THERAPY.
Authors: DEREK CHALMERS
Journal: British Journal of Dermatology (1959)

Journal Article A FATAL CASE OF ERYTHEMA MULTIFORME FOLLOWING DEEP X‐RAY THERAPY. Get access DEREK CHALMERS, M.B., Ch.B. DEREK CHALMERS, M.B., Ch.B. Registrar, Department of Dermatology, Aberdeen Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 71, Issue 7, 1 July 1959, Pages 256–260, https://doi.org/10.1111/j.1365-2133.1959.tb13421.x Published: 01 July 1959
Development of a myeloproliferative disorder in a patient with monoclonal gammopathy of undetermined significance secreting immunoglobulin of the M class and treated with thalidomide and anti-CD20 monoclonal antibody
Authors: Maria-Christina Kyrtsonis, Styliani I. Kokoris, Flora N. Kontopidou, Marina P. Siakantaris, Christos Kittas, Gerassimos A. Pangalis
Journal: Blood (2001)
The Abdominojugular Test: Technique and Hemodynamic Correlates
Authors: Gordon A. Ewy
Journal: Annals of Internal Medicine (1988)

To determine the hemodynamic correlates of a modified abdominojugular reflux test.Case series.Referral-based cardiology practice in a university hospital.Two consecutive samples of 65 (group 1) and 21 (group 2) patients having both right and left heart catheterization.Ten seconds of firm midabdominal pressure was applied by hand in all patients. In group 1 patients, right atrial pressures were recorded during this maneuver. In group 2 patients, simultaneous right atrial and pulmonary arterial wedge pressures were recorded during this maneuver. In group 2 patients, this abdominojugular test was also done at the bedside before cardiac catheterization by observing the changes in the jugular venous pressure.Positive results on an abdominojugular test, defined as an increase in the right atrial pressure during 10 seconds of firm midabdominal compression followed by an abrupt drop in pressure of at least 3 mm Hg (4 cm of blood) on pressure release, were found in patients who as a group had hemodynamic evidence of left ventricular failure. The patients with a positive response had lower left ventricular ejection fractions and stroke volumes, and higher left ventricular filling, higher mean pulmonary arterial, and higher right atrial pressures. The pulmonary arterial occluded or wedge pressures provided the clearest separation between patients with and without a positive response. The mean pulmonary arterial wedge pressure was 10.5 +/- 1 mm Hg in patients with a negative response and 19 +/- 3 mm Hg in patients with a positive response (P less than 0.001). In all but one of the group 2 patients, miabdominal pressure produced similar directional changes in both the right atrial and pulmonary arterial wedge pressures.The abdominojugular test, when done in a standardized fashion, correlates best with the pulmonary arterial wedge pressure, and therefore, is probably a reflection of an increased central blood volume. In the absence of isolated right ventricular failure, seen in some patients with right ventricular infarction, a positive abdominojugular test suggests a pulmonary artery wedge pressure of 15 mm Hg or greater.
Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase
Authors: Masakazu Fujii, Toyoshi Inoguchi, Shuji Sasaki, Yasutaka Maeda, Jing Zheng, Kunihisa Kobayashi, Ryoichi Takayanagi
Journal: Kidney International (2010)
Hookworm Infection in Great Britain
Authors: F. N. Bamford
Journal: BMJ (1965)

it was decided to try the effect of an oral contra- ceptive using the normal contraceptive-dosage routine (2.5 mg.Norethynodrel and 0.1 mg.Mestranol daily for 20 days).Breakthrough bleeding was a problem at 16-17 days, so the dose was doubled for the first 10 days of the cycle.Six weeks after commencing treatment the patches of alopecia were noted to have fine hairs growing centrally, and at four months satisfactory regrowth was established.This was maintained for a further eight months, when she left my care.
The Management of Ureteral Stones
Authors: Myron H. Nourse
Journal: JAMA (1966)

The earliest specimen of vesical calculus was discovered by Prof Elliot Smith<sup>1</sup>in the grave of a predynastic and prehistoric Egyptian boy of 15 or 16. He considered it to have been several centuries prior to Mena, the first king of Egypt, who reigned somewhere between the years 4800 and 4500 BC. The calculus must, therefore, be about 7,000 years old at the present time. It rests in the Hunterian Museum, Royal College of Surgeons, England. Hippocrates<sup>2</sup>(460-370 BC) recognized both renal and vesical calculus and described symptoms of each. He was a daring surgeon but he considered wounds of the bladder to be mortal and forbade his followers to operate for a stone in the bladder. You may recall that he makes mention of this in his famous oath, "Neither will I cut them that have stone, but will leave this operation to those who are accustomed
Angiotensin-Converting Enzyme Inhibitor, Angiotensin Receptor Blocker Use, and Mortality in Patients With Chronic Kidney Disease
Authors: Miklos Z. Molnar, Kamyar Kalantar-Zadeh, Evan H. Lott, Jun Ling Lu, Sandra M. Malakauskas, Jennie Z. Ma, Darryl L. Quarles, Csaba P. Kovesdy
Journal: Journal of the American College of Cardiology (2013)
D-penicillamine-induced enhancement of the delayed hypersensitivity reaction in guinea-pigs.
Authors: T Honma, Y Nakayama
Journal: Annals of the Rheumatic Diseases (1982)

Intraperitoneal gelatin sponge implants were used in guinea-pigs to examine the effect of D-penicillamine on the delayed hypersensitivity reaction in vivo. When it was administered daily in a dose of 200 mg/kg for 14 days before sensitisation or for 14 or 30 days before challenge, D-penicillamine increased the number of exudate cells during the onset of the delayed hypersensitivity reaction. About 20% more polymorphonuclear cells accumulated in the sponges within 6-12 hours of implantation than did without D-penicillamine. Moreover, mononuclear cells also increased up to 20%, but this effect was apparent only 24 to 72 hours after sponge implantation and if D-penicillamine had been administered immediately before challenge.