Insulin Combination Therapy in Type 2 Diabetes Mellitus
Authors: Nasser Mikhail
Journal: Annals of Internal Medicine (2004)

Letters20 April 2004Insulin Combination Therapy in Type 2 Diabetes MellitusNasser Mikhail, MD, MSc and Soma Wali, MDNasser Mikhail, MD, MScFrom Olive View–UCLA Medical Center, Sylmar, CA 91342.Search for more papers by this author and Soma Wali, MDFrom Olive View–UCLA Medical Center, Sylmar, CA 91342.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-8-200404200-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We have a few concerns about the article by Fritsche and colleagues (1) that are related to the use of insulin glargine in combination with glimepiride. First, the open-label design of the study, which was sponsored by the manufacturer of insulin glargine, may have led to bias. The investigators may have given more attention to the morning insulin glargine group in terms of adjustment of insulin doses and degree of adherence to glimepiride therapy (which was not mentioned in the article). This increased attention could have contributed to the apparent greater effectiveness of morning insulin glargine compared ...References1. Fritsche A, Schweitzer MA, Häring HU. Glimepiride combined with morning insulin glargine, bedtime neutral protamine hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes. A randomized, controlled trial. Ann Intern Med. 2003;138:952-9. [PMID: 12809451] LinkGoogle Scholar2. Hamann A, Matthaei S, Rosak C, Silvestre L. A randomized clinical trial comparing breakfast, dinner, or bedtime administration of insulin glargine in patients with type 1 diabetes. Diabetes Care. 2003;26:1738-44. [PMID: 12766103] CrossrefMedlineGoogle Scholar3. Tsunekawa T, Hayashi T, Suzuki Y, Matsui-Hirai H, Kano H, Fukatsu A, et al . Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects. Diabetes Care. 2003;26:285-9. [PMID: 12547850] CrossrefMedlineGoogle Scholar4. Mikhail N. Postprandial hyperglycemia and risk of atherosclerosis [Letter]. JAMA. 2002;288:955. [PMID: 12190355] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Nasser Mikhail, MD, MSc; Soma Wali, MDAffiliations: From Olive View–UCLA Medical Center, Sylmar, CA 91342. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGlimepiride Combined with Morning Insulin Glargine, Bedtime Neutral Protamine Hagedorn Insulin, or Bedtime Insulin Glargine in Patients with Type 2 Diabetes Andreas Fritsche , Matthias Axel Schweitzer , and Hans-Ulrich Hring , and the 4001 Study Group*Insulin Combination Therapy in Type 2 Diabetes Mellitus Andreas Fritsche , Hans-Ulrich Häring , and Matthias Axel Schweitzer Insulin Combination Therapy in Type 2 Diabetes Mellitus Yusuf Hassan , Gaurav Gupta , and Saira Hassan Metrics 20 April 2004Volume 140, Issue 8Page: 666-667KeywordsBlood plasmaGlucoseInsulinInsulin resistanceMorbidityMortalityTreatment guidelinesType 1 diabetesType 2 diabetesWeight gain ePublished: 20 April 2004 Issue Published: 20 April 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...