tbuckley/cabot-search huggingface dataset:
Psychiatry's Integration with Medicine: The Role of DSM-5
Authors: David J. Kupfer, Emily A. Kuhl, Lawson Wulsin
Journal: Annual Review of Medicine (2013)

Mental disorders represent a significant global burden whose effects are exacerbated by gaps in diagnosis and service provision. A substantial number of individuals seek services not through specialty psychiatric clinics but through primary care. Thus, the interface between psychiatry and the rest of medicine represents an appropriate area of focus in which to improve the detection and treatment of mental disorders. Development of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) can play a key role in this process. DSM-5 is expected to include specific revisions in diagnostic criteria, chapter organization, text structure, and classification approach that are designed to improve use of DSM by nonpsychiatrist physicians. Furthermore, revisions to DSM-5 will inform development of the primary care version of DSM-5. The goal is to publish a manual that enhances clinical utility in a manner that is concise and more amenable to use in primary care.
Relationship between Disturbed Eating Behavior and Other Psychosomatic Symptoms in Adolescents
Authors: B. Buddeberg-Fischer, R. Bernet, J. Schmid, C. Buddeberg
Journal: Psychotherapy and Psychosomatics (1996)

Background: There has been relatively little research on subthreshold eating disorders and factors which might promote their transition to eating disorders. Methods: A sample consisting of 1,944 Swiss adolescents of both sexes, 14–19 years of age, was investigated for eating behavior (EAT-26), psychological (SCL-90-R) and physical symptoms (GSCL-C). In addition, the relationship between eating behavior and other psychosomatic symptoms was analyzed. Results: The results revealed significantly higher scores for females than males on all except one scale of the questionnaires. Three categories of disturbed eating behavior based on the EAT scores were described: EAT 0––9 = not disturbed (77.5% girls, 93.1% boys), EAT 10–19 = moderately disturbed (14.1% girls, 5.5% boys), and EAT ≥20 = severely disturbed (8.3% girls, 1.5% boys). With regard to the three aspects, eating habits, psychosomatic symptoms and suicidality a significant correlation between disturbed eating behavior and concurrent psychological and physical symptoms was found in female but not in male subjects. Conclusions: The results emphasized that disordered eating behavior has to be seen as part of a broader psychopathological syndrome, especially in young women.
HEMOGLOBIN LEVELS AT ADMISSION ADD PROGNOSTIC VALUE TO THE GRACE SCORE IN NON-ST ELEVATION ACUTE CORONARY SYNDROMES
Authors: Luis Correia, Jamile Leal, Maria C. Almeida, Alexandre C. Souza, Ana P. Bittencourt, Rafael Freitas, J Péricles Esteves
Journal: Journal of the American College of Cardiology (2010)
Counterimmunoelectrophoresis in the Detection of Antibodies Against Coccidioides immitis
Authors: Francisco G. Aguilar-Torres, Leon J. Jackson, Julian E. Ferstenfeld, Demosthenes Pappagianis, Michael W. Rytel
Journal: Annals of Internal Medicine (1976)

In recent years counterimmunoelectrophoresis has been increasingly used in the diagnosis of microbial diseases, and our study was undertaken to evaluate its possible use in the rapid detection of antibodies against Coccidioides immitis. One hundred twelve specimens from 50 patients were studied. The study population comprised the following: Group I, 34 patients with an active coccidioidomycosis infection; Group II, five patients with a positive coccidioidin skin test; Group III, five patients with a negative coccidioidin skin test; and Group IV, six patients with other fungal infections. Counterimmunoelectrophoresis was positive in 93 of 96 specimens in Group I and negative in the other groups. The results obtained by counterimmunoelectrophoresis correlated well with complement fixation and double immunodiffusion and indicate that it is an excellent tool for the diagnosis of patients with coccidioidomycosis.
HEMOGLOBIN PRODUCTION FACTORS IN THE HUMAN LIVER
Authors: G. H. Whipple, F. S. Robscheit-Robbins
Journal: The Journal of Experimental Medicine (1933)

Biological assay of the human liver in various types of anemia shows conspicuous differences in the concentration of hemoglobin producing factors. Pernicious anemia shows very high values and the liver in untreated cases may show maximal storage of the hemoglobin producing factors. Liver therapy reduces this store as the missing factor is supplied and new hemoglobin and red cells can be turned out by the marrow. Aplastic anemia likewise shows high concentration of hemoglobin producing factors as there is no outlet for this material through the red marrow. Secondary anemia due to loss of blood will show low normal values but even long standing severe anemia will not seriously deplete this store of hemoglobin producing factors in the liver. Secondary anemia due to blood destruction within the body shows higher values and some excess store of hemoglobin producing factors and iron. Leukemia gives a biological assay like secondary anemia due to blood loss and always presents definite anemia. Iron analyses show conspicuous differences and iron concentration within the liver parenchyma does not in any way parallel the concentration of hemoglobin producing factors. The highest values for iron concentration are found in aplastic anemia (70 mg. per cent)— high values in pernicious anemia (51 mg. per cent)—normal values in leukemia (13 mg. per cent)—and low values in anemia due to loss of blood (5.3 mg. per cent). These findings should aid in a more complete understanding of the pathogenesis and internal metabolism of various anemias.
TCT-695 Clinical Impact and Evolution Of Mitral Regurgitation Following Transcatheter Aortic Valve Replacement: A Meta-Analysis
Authors: Luis Nombela-Franco, Helene Eltchaninoff, Luca Testa, Martin Leon, Ramiro Trillo, Augusto D'Onofrio, John Webb, Sabine Bleiziffer, Martine Gilard, Corrado Tamburino, Francesco Bedogni, Marco Barbanti, Stefano Salizzoni, Bruno Garcia del Blanco, Manel Sabate, Antonella Moreo, Henrique B. Ribeiro, Ignacio J. Amat-Santos, Marina Urena, Ricardo Allende, Eulogio J. Garcia, Carlos Macaya, Philippe Pibarot, Josep Rodes-Cabau
Journal: Journal of the American College of Cardiology (2014)
The Sloan-Kettering Affair
Authors: John H. Raaf
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Gail McBride commendably performed the difficult task of writing the first complete account of the "Sloan-Kettering affair." It is an excellent example of responsible investigative reporting and is sympathetic, fair, and balanced (229:1391, 1974). All journalists who have tried to report this story have had difficulty with such questions as: What can be learned from this episode? Is there too much pressure in science? Is this affair "typical" of science, or a symptom of the funding difficulties in science? My own feeling is that these questions are not very worthwhile because, as is clear from Gail McBride's account, the story mainly concerns a highly personal tragedy of a single individual. It would not be appropriate to speculate here on the psychodynamics involved, but I would agree that self-deception was an important factor. For this reason, the action of the Institute in providing a period of medical leave
PUVA-induced skin pain
Authors: N.P. Burrows, R.C. Ratnavel, P.G. Norris
Journal: British Journal of Dermatology (1993)

Journal Article PUVA‐induced skin pain Get access N.P. Burrows, N.P. Burrows Department of Dermatology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ. U.K. Search for other works by this author on: Oxford Academic Google Scholar R.C. Ratnavel, R.C. Ratnavel Department of Dermatology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ. U.K. Search for other works by this author on: Oxford Academic Google Scholar P.G. Norris P.G. Norris Department of Dermatology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ. U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 129, Issue 4, 1 October 1993, Page 504, https://doi.org/10.1111/j.1365-2133.1993.tb03191.x Published: 01 October 1993
Treatment of Progressive Multifocal Leukoencephalopathy With Interleukin 7
Authors: Karl B. Alstadhaug, Thérèse Croughs, Stian Henriksen, Céline Leboeuf, Irini Sereti, Hans H. Hirsch, Christine Hanssen Rinaldo
Journal: JAMA Neurology (2014)

<h3>Importance</h3> No reliable treatment options are known for progressive multifocal leukoencephalopathy with underlying immunodeficiency. We describe successful compassionate use of recombinant human interleukin 7 in a patient with idiopathic CD4<sup>+</sup>T-cell lymphocytopenia. <h3>Observations</h3> After the diagnoses of progressive multifocal leukoencephalopathy and idiopathic CD4<sup>+</sup>T-cell lymphocytopenia were established, a 61-year-old man was treated with recombinant human interleukin 7 on November 1, 2012. Except for an episode of epilepsia partialis continua on January 16, 2013, a gradual clinical improvement was observed until March. Abnormalities shown on magnetic resonance imaging regressed; JC virus DNA in plasma, likely originating from the brain based on sequencing data, cleared; and increases in peripheral CD4<sup>+</sup>T cells and JC virus intrathecal antibodies were observed. One year after treatment, the CD4<sup>+</sup>T-cell count returned to baseline and the clinical improvement waned, possibly due to the patient's complex epilepsy. On the latest evaluation on January 14, 2014, the patient's condition was unchanged, with no signs of ongoing central nervous system infection. <h3>Conclusions and Relevance</h3> The present case argues strongly for proof of the treatment concept. However, deeper insight into the JC virus and its pathogenesis and the immune response during central nervous system infection as well as further clinical studies are needed before recombinant human interleukin 7 can be recommended for the treatment of other cases of immunodeficiency and progressive multifocal leukoencephalopathy.
Isoniazid and Bile Duct Cancer
Authors: Albert B. Lowenfels
Journal: JAMA (1978)

<h3>To the Editor.—</h3> There has been concern that isoniazid (INH) may be carcinogenic for man<sup>1,2</sup>since it contains hydrazine, a known carcinogen,<sup>3</sup>and because it produces a variety of experimental tumors (<i>IARC Monogr Eval Carcinog Risk Chem Man</i>4:159, 1974). We report two cases of bile duct cancer where there was exposure to INH. <h3>Report of Cases.—</h3> A 55-year-old man had a well-differentiated bile duct cancer at the junction of the right and left hepatic ducts 18 years after receiving INH (total dose, 122 g) for pulmonary tuberculosis. A 71-year-old alcoholic man was hospitalized with obstructive jaundice two years after receiving INH (total dose, 36 g) for suspected tuberculosis. He also had a well-differentiated bile duct adenocarcinoma. Although the relation between INH exposure and these two rare cancers may only be coincidental, these were the only bile duct cancers encountered at our hospital from 1970 to 1977, a
Physicians in opera—reflection of medical history and public perception
Authors: Stefan N Willich
Journal: BMJ (2006)

Music plays an increasingly important part in medicine, such as in specific care for performing artists.1 But what about the representation of medicine in music? 

A systematic search in theatrical reference books yielded 40 operas from three centuries in which physicians appear on stage (see table on bmj.com). I selected several operas as specific examples in the history of opera. I analysed the role and function of the physician in different categories including the character and importance of his role, his function and basis of knowledge, and his social status. I also looked at the historical context. 

Opera developed in the late Renaissance and early Baroque.2 There are no doctors in the operas of Monteverdi, Gluck, or Handel, partly because the stories are often based on material from mythology or antiquity. In the 18th century, however, our colleagues enter the stage. 

Le Nozze di Figaro (The Marriage of Figaro, premiered 1786) is one of Mozart's great operas. Among the secondary characters is Dr Bartolo, a physician who does not appear in his role as a healer. He is angry with Figaro and threatens to take revenge on him for having once helped to abduct his ward Rosina, who Bartolo wanted to marry. Towards the end of the opera, however, Dr Bartolo sides with Figaro after finding out by chance that Figaro is his lost son who had been abducted as a baby. 

In Doktor und Apotheker (Doctor and Pharmacist, 1786) by Carl Ditters von Dittersdorf, the physician Dr Krautmann extols his importance in the introductory aria. The satirical way in which this is done leaves doubt as to his real reputation. Dr Krautmann's son and the pharmacist Stoessel's daughter are in love with each other. When Stoessel finds this out, he tries to marry his daughter off to …
A CASE OF RECOVERY FROM PEMPHIGUS FOLIACEUS
Authors: J. FERGUSON SMITH
Journal: British Journal of Dermatology (1932)

Journal Article A CASE OF RECOVERY FROM PEMPHIGUS FOLIACEUS Get access J. FERGUSON SMITH, M.A., M.B., Ch.B. J. FERGUSON SMITH, M.A., M.B., Ch.B. Physician for Diseases of the Skin, Royal Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 44, Issue 12, 1 December 1932, Pages 588–590, https://doi.org/10.1111/j.1365-2133.1932.tb09565.x Published: 01 December 1932
Proactive Treatment Decreased Serum IgE Titer Significantly in Patients with Severe Atopic Dermatitis (AD)
Authors: T. Fukuie, I. Nomura, K. Horimukai, T. Oishi, A. Manki, M. Narita, A. Akasawa, Y. Ohya
Journal: Journal of Allergy and Clinical Immunology (2009)
You can cheat people, but not nature!
Authors: John Barresi
Journal: Behavioral and Brain Sciences (1995)

Abstract The psychological mechanisms implicated in psychopathy do not limit their activity to those behaviors that support a cheater strategy in social games. They result in a number of other clearly maladaptive behaviors that do not directly involve other individuals. Thus, any gains that might arise from the use of a cheater strategy in social situations are probably lost elsewhere.
Cleft Craft: The Evolution of Its Surgery, vol 2: Bilateral and Rare Deformities
Authors: Blair O. Rogers
Journal: JAMA (1978)

This scholarly book is the second of three volumes on cleft lip, cleft palate, and associated deformities, written by one of the leading authorities in plastic and reconstructive surgery today. In a text filled with abundant illustrations—sketches, portraits, and colored plates—Millard describes the many procedures developed during the past 150 years or more in the repair of the bilateral cleft lip deformity. Special chapters are devoted to bilateral cleft embryology, cleft anatomy, what to do or not to do about the projecting premaxillary segment, the optimum time for bilateral cleft lip surgery, the surgical evolution of repair of bilateral cleft lips, and the treatment of secondary bilateral deformities such as skin scars, muscle discrepancies, and philtrum deformities. In these chapters Millard provides a one-man symposium based on more than three decades of personal experience in treating these deformities. A special section deals with the rare deformities that have not often
Oesophageal variceal bleeding in Felty's syndrome associated with nodular regenerative hyperplasia.
Authors: L M Blendis, D Lovell, C G Barnes, S Ritland, D Cattan, P Vesin
Journal: Annals of the Rheumatic Diseases (1978)

Four patients with Felty's syndrome developed massive upper gastrointestinal bleeding due to oesophageal varices. The underlying hepatic pathology in all 4 was nodular regenerative hyperplasia. This appears to be a difficult histological diagnosis to make, having been initially reported as normal on percutaneous biopsy or as fibrosis or cirrhosis on wedge biopsy. This series brings the total number of cases reported in the English literature of this association to 12, suggesting a definite symptom complex. The portal hypertension seems to be due to a combination of increased splenic blood flow and postsinusoidal resistance. The clinical importance of this syndrome is that the appropriate therapy for bleeding oesophageal varices appears to be shunt procedure such as a splenorenal shunt with splenectomy, which should be well tolerated.
Antiangiogenic and Antitumor Efficacy of EphA2 Receptor Antagonist
Authors: Pawel Dobrzanski, Kathryn Hunter, Susan Jones-Bolin, Hong Chang, Candy Robinson, Sonya Pritchard, Hugh Zhao, Bruce Ruggeri
Journal: Cancer Research (2004)

Abstract Tumor-associated angiogenesis is critical for tumor growth and metastasis and is controlled by various pro- and antiangiogenic factors. The Eph family of receptor tyrosine kinases has emerged as one of the pivotal regulators of angiogenesis. Here we report that interfering with EphA signaling resulted in a pronounced inhibition of angiogenesis in ex vivo and in vivo model systems. Administration of EphA2/Fc soluble receptors inhibited, in a dose-dependent manner, microvessel formation in rat aortic ring assay, with inhibition reaching 76% at the highest dose of 5000 ng/ml. These results were further confirmed in vivo in a porcine aortic endothelial cell-vascular endothelial growth factor (VEGF)/basic fibroblast growth factor Matrigel plug assay, in which administration of EphA2/Fc soluble receptors resulted in 81% inhibition of neovascularization. The additive effects of simultaneous inhibition of VEGF receptor 2 and EphA signaling pathways in aortic ring assay and antiangiogenic efficacy of EphA2/Fc soluble receptors against VEGF/basic fibroblast growth factor-mediated neovascularization in vivo indicated a critical and nonredundant role for EphA signaling in angiogenesis. Furthermore, in two independent experiments, we demonstrated that EphA2/Fc soluble receptors strongly (by ∼50% versus controls) suppressed growth of ASPC-1 human pancreatic tumor s.c. xenografts. Inhibition of tumor growth was due to decreased proliferation of tumor cells. In an orthotopic pancreatic ductal adenocarcinoma model in mice, suppression of EphA signaling by i.p. administration of EphA2/Fc (30 μg/dose, three times a week for 56 days) profoundly inhibited the growth of primary tumors and the development of peritoneal, lymphatic, and hepatic metastases. These data demonstrate a critical role of EphA signaling in tumor growth and metastasis and provide a strong rationale for targeting EphA2 receptors for anticancer therapies.
Skin Pigmentation in Wilson's Disease
Authors: M. L. Leu
Journal: JAMA (1970)

Twelve of 20 patients (60%) with Wilson's disease (hepatolenticular degeneration) were noted to have hyperpigmentation on the anterior aspect of the lower part of the legs. Histologically, this was found to be caused by increased melanin deposition. Copper and iron content in skin biopsy specimens was not different from that in controls.
Fetal monitoring during labour.
Authors: R S Sawers
Journal: BMJ (1983)

Fetal monitoring during labourIs fetal monitoring worth while ?was the title ofa leading article in the BMJ in 19711 which concluded that continuous monitor- ing of the fetal heart rate and measurement of scalp pH might allow labour to be undertaken and continued in high risk pregnancy where otherwise a caesarean section would be performed.The article suggested that intrapartum monitoring might allow early detection of asphyxia and reduce the number of asphyxiated infants delivered, although it drew attention to the lack of published evidence to support this.Since then, numerous retrospective analyses and five prospective randomised controlled trials-three in high risk2-4 and two in low risk56 pregnancy-have been published, showing that continuous monitoring of the fetal heart rate in high risk pregnancy may prevent intrapartum stillbirths and reduce neurological complications in neonates, but that this may be at the expense of an increase in the rate of caesarean section.The concurrent use of fetal scalp blood sampling may not only improve the fetal outcome but also reduce the caesarean section rate.Such benefits, however, were not apparent in the low risk pregnancies.Though these studies confirm that fetal monitoring may prevent neurological sequels, they fail to show a significant improvement overall in the condition of the fetus at birth.This suggests that, although monitoring detects severe fetal distress, it fails to detect less severe cases.In a study by Sykes et al (1 October, p 943) of selective monitoring ofhigh risk pregnancies and those in which the fetal heart rate was abnormal on auscultation, monitoring de- tected fetal distress in only 16% ofcases in which the infant was subsequently found to have severe acidosis and an Apgar score of less than 7 at one minute.Conversely, most of the infants who were thought to have had fetal distress were vigorous and were not severely acidotic.The authors monitored 46% of the labours, and almost half of the infants who were born with severe acidosis occurred in the supposedly low risk group who were not monitored.Failure to identify those at risk has been noted before and led to the recommendation that all labours should be monitored.7Possibly this may be supported by a sufficiently large randomised trial, but it is probably now more important to seek to improve on current techniques than to strive to justify them, if the benefit is not immediately obvious.The need for adequate intrapartum monitoring cannot be denied, but unfortunately, objective evaluation of continuous fetal monitoring has lagged behind
A DEFINITE AND UNIQUE OCCURRENCE OF RAPIDLY FATAL INFECTION CAUSED BY BACILLUS VIOLACEUS MANILAE
Authors: Herbert J. Schattenberg
Journal: JAMA (1941)

Considerable skepticism is extant regarding the pathogenicity of Bacillus violaceus. It has been generally considered as a nonpathogenic saprophyte having a rather ubiquitous distribution. More careful perusal and consideration of the sparse literature pertinent to this subject reveals, however, that much of the doubt is due to failure of recognition of the fact that many distinctive species exist in the group of which Chromobacterium violaceum is the type species. For a comprehensive classification of this group as regards both the cultural and the pathogenic aspect, the reader is referred to the presentation of Ford.<sup>1</sup> Woolley<sup>2</sup>identified by pathogenicity and by other specific biologic reactions a species of this group producing fulminating fatal infections in the caribao, or water buffalo, which he termed B. violaceus manilae. In the 2 human cases recorded, one by Black and Shahan<sup>3</sup>and the other by Soule,<sup>4</sup>the durations of illness were
Poly(vinyl chloride) processes and products.
Authors: R N Wheeler
Journal: Environmental Health Perspectives (1981)

Poly(vinyl chloride) resins are produced by four basic processes: suspension, emulsion, bulk and solution polymerization. PVC suspensions resins are usually relatively dust-free and granular with varying degrees of particle porosity. PVC emulsion resins are small particle powders containing very little free monomer. Bulk PVC resins are similar to suspension PVC resins, though the particles tend to be more porous. Solution PVC resins are smaller in particle size than suspension PVC with high porosity particles containing essentially no free monomer. The variety of PVC resin products does not lend itself to broad generalizations concerning health hazards. In studying occupational hazards the particular PVC process and the product must be considered and identified in the study.
On the Management of Perforations of the Membrana Tympani
Authors: William B Dalby
Journal: BMJ (1887)

but these, under microscope, showed the same turgescence and soundness as in younger persons.Haller notes the absence of mesenteric system in advanced years.Spleen small, weighing 2 ounces ; capsule tuber- culated.Concretions of uric acid abundant in pelvis and calices of right kidney, and in bladder.Right kidney, 2i ounces; left, 2i; both