Severe but Reversible Neurotoxicity from Acyclovir
Authors: S M Cohen, J A Minkove, J W Zebley rd, J H Mulholland
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 June 1984Severe but Reversible Neurotoxicity from AcyclovirSANDER M. Z. COHEN, M.D., JUDAH A. MlNKOVE, M.D., JOSEPH W. ZEBLEY III, M.D., JOHN H. MULHOLLAND, M.D.SANDER M. Z. COHEN, M.D., JUDAH A. MlNKOVE, M.D., JOSEPH W. ZEBLEY III, M.D., JOHN H. MULHOLLAND, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-6-920_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A few cases of mild to moderate neurologic toxicity caused by intravenous acyclovir therapy have been reported recently (1-5). We present the case of an immunocompetent patient who developed severe, reversible neurologic complications.A previously healthy 80-year-old white woman was hospitalized for cutaneous herpes zoster. Physical findings were significant only for zoster of the first and second division of the left trigeminal nerve. Laboratory values on admission were normal.On the evening of admission the patient was begun on a regimen of intravenous acyclovir, 800 mg every 8 hours (1500 mg/m2 body surface area), and dexamethasone eye...References1. WADEMEYERS JJ. Neurologic symptoms associated with parenteral acyclovir treatment after marrow transplantation. Ann Intern Med. 1983;98:921-5. LinkGoogle Scholar2. SARALBURNSLASKINSANTOSLIETMAN RWOGP. Acyclovir prophylaxis of herpes-simplex-virus infections: a randomized double-blind controlled trial in bone-marrow transplant recipients. N Engl J Med. 1982;305:63-7. CrossrefGoogle Scholar3. MEYERSWADEMITCHELL JJC. Multicenter collaborative trial of intravenous acyclovir for the treatment of mucocutaneous herpes simplex virus infection in the immunocompromised host. Am J Med. 1982;73(suppl):229-35. CrossrefMedlineGoogle Scholar4. STRAUSSMITHBRICKMANDEMIRANDAMCLARENKEENEY SHCPCR. Acyclovir for chronic mucocutaneous herpes simplex virus infection in immunosuppressed patients. Ann Intern Med. 1982;96:270-6. LinkGoogle Scholar5. ANWERXKNOCKAERTHOFKENS JDP. Acyclovir and neurologic manifestations. Ann Intern Med. 1983;99:882-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Union Memorial Hospital Baltimore, MD 21218 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeurotoxicity associated with acyclovir and valacyclovir: A systematic review of casesA Case Report of Neurotoxicity After Prolonged Doses of Acyclovir in a Patient With Renal DysfunctionSevere mental disorders following anti-retroviral treatment in a patient on peritoneal dialysis: A case report and literature reviewAcyclovir-Induced NeurotoxicityAntiviral Agents☆Neurologic complications in renal transplantationAciclovir neurotoxicity is an important side effect of therapy in patients with renal impairmentNeurologic complications of bone marrow transplantationNeurologic Complications of Hematopoietic Stem Cell TransplantationHerpes simplex viruses 1 and 2Acyclovir Induced Coma in the Intensive Care UnitAntiviral agentsDiffuse white matter lesions associated with herpes simplex encephalitis as observed on magnetic resonance imagingChemotherapy of varicella zoster virus infectionsAcute Renal Failure and Neurotoxicity following Oral AcyclovirMedikamentös induzierte Psychose bei einer HIV-infizierten PatientinDistinguishing acyclovir neurotoxicity from encephalomyelitisRapidly Progressive Acute Renal Failure Due to Acyclovir: Case Report and Review of the LiteratureAcyclovir-induced neurotoxicity: Concentration-side effect relationship in acyclovir overdoseAcyclovir Neurotoxicity and Nephrotoxicity-The Role for HemodialysisAcyclovir: A Decade LaterSystemic antiviral drugs used in ophthalmologyPsychiatric Disturbances Associated with Ganciclovir TherapyCentral Nervous SystemAcute Renal Failure and Coma after a High Dose of Oral AcyclovirAcyclovir-induced renal failureMajor Depression with Psychotic Features Associated with Acyclovir TherapyAdverse reactions to acyclovir: Topical, oral, and intravenousDrugs Five Years Later: AcyclovirDAVID I. DORSKY, M.D., Ph.D., CLYDE S. CRUMPACKER, M.D.Chemotherapy of herpesvirus infections: Present successes and future hopesNeurological Complications of Hematopoietic Stem Cell Transplantation 1 June 1984Volume 100, Issue 6Page: 920-920KeywordsBody surface areaNervesResearch laboratoriesToxicity Issue Published: 1 June 1984 PDF downloadLoading ...